data_8YU2
# 
_entry.id   8YU2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YU2         pdb_00008yu2 10.2210/pdb8yu2/pdb 
WWPDB D_1300046361 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YU2 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              huileiyu@ecust.edu.cn 
_pdbx_contact_author.name_first         Yu 
_pdbx_contact_author.name_last          Huilei 
_pdbx_contact_author.name_mi            H 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1925-3679 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Qiang, G.'   1 0000-0003-2842-8263 
'Zheng, Y.C.' 2 ?                   
'Feng, L.'    3 ?                   
'Yu, H.L.'    4 0000-0002-1925-3679 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Loop Engineering Facilitates the Nicotinamide Cofactors Utilization of BVMOs' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Qiang, G.'   1 0000-0003-2842-8263 
primary 'Zheng, Y.C.' 2 ?                   
primary 'Feng, L.'    3 ?                   
primary 'Yu, H.L.'    4 0000-0002-1925-3679 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Putative flavin-binding monooxygenase' 62006.062 1   ? 
L143P,F246Y,K326C,N386S,I388K,M390I,L426F,F432L,T433A,L435S,S438I,E488K,S489C,W490R,F505L ? 'N-end fusion of HIS tags' 
2 non-polymer syn 'FLAVIN-ADENINE DINUCLEOTIDE'           785.550   1   ? ? ? ?                          
3 non-polymer syn NICOTINAMIDE-ADENINE-DINUCLEOTIDE       663.425   1   ? ? ? ?                          
4 water       nat water                                   18.015    122 ? ? ? ?                          
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MHHHHHHTQKMDFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGTWFWNQYPGALSDSETHLYCYSWDKELLQE
MEIKRKYISQPDVLAYLKRVADKHDLRKDIQFETGIRSAYFDEENSFWNVTTENDEKFTARFLITALGPLAAPNLPKIKG
IETFKGELHHTSRWPKDVTFSGKRVGVIGTGSTGVQVITAIASQVKHLTVFQRSAQYSVPIGNVVMSETDVAKIKENYDQ
IWENVWNSALGYGLNESTLPTMSVSAEERDKIFEKAWQEGGGFRFMFETFGDIAVDETANIEAQNFIKKKISEIVKDPFV
AKKLTPTDLYACRPLCDSGYYEIFNRDNVSLEDVKANPIVEIKEDCVVTADGVEHKLDMLICATGFDAVDGSYKRIDIRG
KDGISIKDHWKDGPNSYLGMMVSNFPNMFMVFGPNGPLANSPPIIETQVRWIADLIGYAEDHQINQIEATKDAVDNWTNT
CSDIANKTLFAKAKCRIFGANVPGKKNTVYLYMGGLKEYRNQISEVSNNNYKGCLLKQSVKKTNLIES
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MHHHHHHTQKMDFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGTWFWNQYPGALSDSETHLYCYSWDKELLQE
MEIKRKYISQPDVLAYLKRVADKHDLRKDIQFETGIRSAYFDEENSFWNVTTENDEKFTARFLITALGPLAAPNLPKIKG
IETFKGELHHTSRWPKDVTFSGKRVGVIGTGSTGVQVITAIASQVKHLTVFQRSAQYSVPIGNVVMSETDVAKIKENYDQ
IWENVWNSALGYGLNESTLPTMSVSAEERDKIFEKAWQEGGGFRFMFETFGDIAVDETANIEAQNFIKKKISEIVKDPFV
AKKLTPTDLYACRPLCDSGYYEIFNRDNVSLEDVKANPIVEIKEDCVVTADGVEHKLDMLICATGFDAVDGSYKRIDIRG
KDGISIKDHWKDGPNSYLGMMVSNFPNMFMVFGPNGPLANSPPIIETQVRWIADLIGYAEDHQINQIEATKDAVDNWTNT
CSDIANKTLFAKAKCRIFGANVPGKKNTVYLYMGGLKEYRNQISEVSNNNYKGCLLKQSVKKTNLIES
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'FLAVIN-ADENINE DINUCLEOTIDE'     FAD 
3 NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD 
4 water                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   THR n 
1 9   GLN n 
1 10  LYS n 
1 11  MET n 
1 12  ASP n 
1 13  PHE n 
1 14  ASP n 
1 15  ALA n 
1 16  ILE n 
1 17  ILE n 
1 18  ILE n 
1 19  GLY n 
1 20  ALA n 
1 21  GLY n 
1 22  PHE n 
1 23  GLY n 
1 24  GLY n 
1 25  LEU n 
1 26  TYR n 
1 27  SER n 
1 28  LEU n 
1 29  LYS n 
1 30  LYS n 
1 31  LEU n 
1 32  ARG n 
1 33  ASP n 
1 34  ASP n 
1 35  PHE n 
1 36  ASN n 
1 37  LEU n 
1 38  LYS n 
1 39  VAL n 
1 40  ARG n 
1 41  ALA n 
1 42  PHE n 
1 43  ASP n 
1 44  ARG n 
1 45  ALA n 
1 46  THR n 
1 47  GLU n 
1 48  VAL n 
1 49  GLY n 
1 50  GLY n 
1 51  THR n 
1 52  TRP n 
1 53  PHE n 
1 54  TRP n 
1 55  ASN n 
1 56  GLN n 
1 57  TYR n 
1 58  PRO n 
1 59  GLY n 
1 60  ALA n 
1 61  LEU n 
1 62  SER n 
1 63  ASP n 
1 64  SER n 
1 65  GLU n 
1 66  THR n 
1 67  HIS n 
1 68  LEU n 
1 69  TYR n 
1 70  CYS n 
1 71  TYR n 
1 72  SER n 
1 73  TRP n 
1 74  ASP n 
1 75  LYS n 
1 76  GLU n 
1 77  LEU n 
1 78  LEU n 
1 79  GLN n 
1 80  GLU n 
1 81  MET n 
1 82  GLU n 
1 83  ILE n 
1 84  LYS n 
1 85  ARG n 
1 86  LYS n 
1 87  TYR n 
1 88  ILE n 
1 89  SER n 
1 90  GLN n 
1 91  PRO n 
1 92  ASP n 
1 93  VAL n 
1 94  LEU n 
1 95  ALA n 
1 96  TYR n 
1 97  LEU n 
1 98  LYS n 
1 99  ARG n 
1 100 VAL n 
1 101 ALA n 
1 102 ASP n 
1 103 LYS n 
1 104 HIS n 
1 105 ASP n 
1 106 LEU n 
1 107 ARG n 
1 108 LYS n 
1 109 ASP n 
1 110 ILE n 
1 111 GLN n 
1 112 PHE n 
1 113 GLU n 
1 114 THR n 
1 115 GLY n 
1 116 ILE n 
1 117 ARG n 
1 118 SER n 
1 119 ALA n 
1 120 TYR n 
1 121 PHE n 
1 122 ASP n 
1 123 GLU n 
1 124 GLU n 
1 125 ASN n 
1 126 SER n 
1 127 PHE n 
1 128 TRP n 
1 129 ASN n 
1 130 VAL n 
1 131 THR n 
1 132 THR n 
1 133 GLU n 
1 134 ASN n 
1 135 ASP n 
1 136 GLU n 
1 137 LYS n 
1 138 PHE n 
1 139 THR n 
1 140 ALA n 
1 141 ARG n 
1 142 PHE n 
1 143 LEU n 
1 144 ILE n 
1 145 THR n 
1 146 ALA n 
1 147 LEU n 
1 148 GLY n 
1 149 PRO n 
1 150 LEU n 
1 151 ALA n 
1 152 ALA n 
1 153 PRO n 
1 154 ASN n 
1 155 LEU n 
1 156 PRO n 
1 157 LYS n 
1 158 ILE n 
1 159 LYS n 
1 160 GLY n 
1 161 ILE n 
1 162 GLU n 
1 163 THR n 
1 164 PHE n 
1 165 LYS n 
1 166 GLY n 
1 167 GLU n 
1 168 LEU n 
1 169 HIS n 
1 170 HIS n 
1 171 THR n 
1 172 SER n 
1 173 ARG n 
1 174 TRP n 
1 175 PRO n 
1 176 LYS n 
1 177 ASP n 
1 178 VAL n 
1 179 THR n 
1 180 PHE n 
1 181 SER n 
1 182 GLY n 
1 183 LYS n 
1 184 ARG n 
1 185 VAL n 
1 186 GLY n 
1 187 VAL n 
1 188 ILE n 
1 189 GLY n 
1 190 THR n 
1 191 GLY n 
1 192 SER n 
1 193 THR n 
1 194 GLY n 
1 195 VAL n 
1 196 GLN n 
1 197 VAL n 
1 198 ILE n 
1 199 THR n 
1 200 ALA n 
1 201 ILE n 
1 202 ALA n 
1 203 SER n 
1 204 GLN n 
1 205 VAL n 
1 206 LYS n 
1 207 HIS n 
1 208 LEU n 
1 209 THR n 
1 210 VAL n 
1 211 PHE n 
1 212 GLN n 
1 213 ARG n 
1 214 SER n 
1 215 ALA n 
1 216 GLN n 
1 217 TYR n 
1 218 SER n 
1 219 VAL n 
1 220 PRO n 
1 221 ILE n 
1 222 GLY n 
1 223 ASN n 
1 224 VAL n 
1 225 VAL n 
1 226 MET n 
1 227 SER n 
1 228 GLU n 
1 229 THR n 
1 230 ASP n 
1 231 VAL n 
1 232 ALA n 
1 233 LYS n 
1 234 ILE n 
1 235 LYS n 
1 236 GLU n 
1 237 ASN n 
1 238 TYR n 
1 239 ASP n 
1 240 GLN n 
1 241 ILE n 
1 242 TRP n 
1 243 GLU n 
1 244 ASN n 
1 245 VAL n 
1 246 TRP n 
1 247 ASN n 
1 248 SER n 
1 249 ALA n 
1 250 LEU n 
1 251 GLY n 
1 252 TYR n 
1 253 GLY n 
1 254 LEU n 
1 255 ASN n 
1 256 GLU n 
1 257 SER n 
1 258 THR n 
1 259 LEU n 
1 260 PRO n 
1 261 THR n 
1 262 MET n 
1 263 SER n 
1 264 VAL n 
1 265 SER n 
1 266 ALA n 
1 267 GLU n 
1 268 GLU n 
1 269 ARG n 
1 270 ASP n 
1 271 LYS n 
1 272 ILE n 
1 273 PHE n 
1 274 GLU n 
1 275 LYS n 
1 276 ALA n 
1 277 TRP n 
1 278 GLN n 
1 279 GLU n 
1 280 GLY n 
1 281 GLY n 
1 282 GLY n 
1 283 PHE n 
1 284 ARG n 
1 285 PHE n 
1 286 MET n 
1 287 PHE n 
1 288 GLU n 
1 289 THR n 
1 290 PHE n 
1 291 GLY n 
1 292 ASP n 
1 293 ILE n 
1 294 ALA n 
1 295 VAL n 
1 296 ASP n 
1 297 GLU n 
1 298 THR n 
1 299 ALA n 
1 300 ASN n 
1 301 ILE n 
1 302 GLU n 
1 303 ALA n 
1 304 GLN n 
1 305 ASN n 
1 306 PHE n 
1 307 ILE n 
1 308 LYS n 
1 309 LYS n 
1 310 LYS n 
1 311 ILE n 
1 312 SER n 
1 313 GLU n 
1 314 ILE n 
1 315 VAL n 
1 316 LYS n 
1 317 ASP n 
1 318 PRO n 
1 319 PHE n 
1 320 VAL n 
1 321 ALA n 
1 322 LYS n 
1 323 LYS n 
1 324 LEU n 
1 325 THR n 
1 326 PRO n 
1 327 THR n 
1 328 ASP n 
1 329 LEU n 
1 330 TYR n 
1 331 ALA n 
1 332 CYS n 
1 333 ARG n 
1 334 PRO n 
1 335 LEU n 
1 336 CYS n 
1 337 ASP n 
1 338 SER n 
1 339 GLY n 
1 340 TYR n 
1 341 TYR n 
1 342 GLU n 
1 343 ILE n 
1 344 PHE n 
1 345 ASN n 
1 346 ARG n 
1 347 ASP n 
1 348 ASN n 
1 349 VAL n 
1 350 SER n 
1 351 LEU n 
1 352 GLU n 
1 353 ASP n 
1 354 VAL n 
1 355 LYS n 
1 356 ALA n 
1 357 ASN n 
1 358 PRO n 
1 359 ILE n 
1 360 VAL n 
1 361 GLU n 
1 362 ILE n 
1 363 LYS n 
1 364 GLU n 
1 365 ASP n 
1 366 CYS n 
1 367 VAL n 
1 368 VAL n 
1 369 THR n 
1 370 ALA n 
1 371 ASP n 
1 372 GLY n 
1 373 VAL n 
1 374 GLU n 
1 375 HIS n 
1 376 LYS n 
1 377 LEU n 
1 378 ASP n 
1 379 MET n 
1 380 LEU n 
1 381 ILE n 
1 382 CYS n 
1 383 ALA n 
1 384 THR n 
1 385 GLY n 
1 386 PHE n 
1 387 ASP n 
1 388 ALA n 
1 389 VAL n 
1 390 ASP n 
1 391 GLY n 
1 392 SER n 
1 393 TYR n 
1 394 LYS n 
1 395 ARG n 
1 396 ILE n 
1 397 ASP n 
1 398 ILE n 
1 399 ARG n 
1 400 GLY n 
1 401 LYS n 
1 402 ASP n 
1 403 GLY n 
1 404 ILE n 
1 405 SER n 
1 406 ILE n 
1 407 LYS n 
1 408 ASP n 
1 409 HIS n 
1 410 TRP n 
1 411 LYS n 
1 412 ASP n 
1 413 GLY n 
1 414 PRO n 
1 415 ASN n 
1 416 SER n 
1 417 TYR n 
1 418 LEU n 
1 419 GLY n 
1 420 MET n 
1 421 MET n 
1 422 VAL n 
1 423 SER n 
1 424 ASN n 
1 425 PHE n 
1 426 PRO n 
1 427 ASN n 
1 428 MET n 
1 429 PHE n 
1 430 MET n 
1 431 VAL n 
1 432 PHE n 
1 433 GLY n 
1 434 PRO n 
1 435 ASN n 
1 436 GLY n 
1 437 PRO n 
1 438 LEU n 
1 439 ALA n 
1 440 ASN n 
1 441 SER n 
1 442 PRO n 
1 443 PRO n 
1 444 ILE n 
1 445 ILE n 
1 446 GLU n 
1 447 THR n 
1 448 GLN n 
1 449 VAL n 
1 450 ARG n 
1 451 TRP n 
1 452 ILE n 
1 453 ALA n 
1 454 ASP n 
1 455 LEU n 
1 456 ILE n 
1 457 GLY n 
1 458 TYR n 
1 459 ALA n 
1 460 GLU n 
1 461 ASP n 
1 462 HIS n 
1 463 GLN n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 ILE n 
1 468 GLU n 
1 469 ALA n 
1 470 THR n 
1 471 LYS n 
1 472 ASP n 
1 473 ALA n 
1 474 VAL n 
1 475 ASP n 
1 476 ASN n 
1 477 TRP n 
1 478 THR n 
1 479 ASN n 
1 480 THR n 
1 481 CYS n 
1 482 SER n 
1 483 ASP n 
1 484 ILE n 
1 485 ALA n 
1 486 ASN n 
1 487 LYS n 
1 488 THR n 
1 489 LEU n 
1 490 PHE n 
1 491 ALA n 
1 492 LYS n 
1 493 ALA n 
1 494 LYS n 
1 495 CYS n 
1 496 ARG n 
1 497 ILE n 
1 498 PHE n 
1 499 GLY n 
1 500 ALA n 
1 501 ASN n 
1 502 VAL n 
1 503 PRO n 
1 504 GLY n 
1 505 LYS n 
1 506 LYS n 
1 507 ASN n 
1 508 THR n 
1 509 VAL n 
1 510 TYR n 
1 511 LEU n 
1 512 TYR n 
1 513 MET n 
1 514 GLY n 
1 515 GLY n 
1 516 LEU n 
1 517 LYS n 
1 518 GLU n 
1 519 TYR n 
1 520 ARG n 
1 521 ASN n 
1 522 GLN n 
1 523 ILE n 
1 524 SER n 
1 525 GLU n 
1 526 VAL n 
1 527 SER n 
1 528 ASN n 
1 529 ASN n 
1 530 ASN n 
1 531 TYR n 
1 532 LYS n 
1 533 GLY n 
1 534 CYS n 
1 535 LEU n 
1 536 LEU n 
1 537 LYS n 
1 538 GLN n 
1 539 SER n 
1 540 VAL n 
1 541 LYS n 
1 542 LYS n 
1 543 THR n 
1 544 ASN n 
1 545 LEU n 
1 546 ILE n 
1 547 GLU n 
1 548 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   548 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 P23_1101 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Acinetobacter calcoaceticus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     471 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                           ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                          ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                        ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                   ? 'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                          ? 'C3 H7 N O2 S'      121.158 
FAD non-polymer         . 'FLAVIN-ADENINE DINUCLEOTIDE'     ? 'C27 H33 N9 O15 P2' 785.550 
GLN 'L-peptide linking' y GLUTAMINE                         ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                   ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                           ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                         ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                             ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                        ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                           ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                            ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                        ? 'C5 H11 N O2 S'     149.211 
NAD non-polymer         . NICOTINAMIDE-ADENINE-DINUCLEOTIDE ? 'C21 H27 N7 O14 P2' 663.425 
PHE 'L-peptide linking' y PHENYLALANINE                     ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                           ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                            ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                         ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                        ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                          ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                            ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -5  ?   ?   ?   A . n 
A 1 2   HIS 2   -4  ?   ?   ?   A . n 
A 1 3   HIS 3   -3  ?   ?   ?   A . n 
A 1 4   HIS 4   -2  ?   ?   ?   A . n 
A 1 5   HIS 5   -1  ?   ?   ?   A . n 
A 1 6   HIS 6   0   ?   ?   ?   A . n 
A 1 7   HIS 7   1   ?   ?   ?   A . n 
A 1 8   THR 8   2   ?   ?   ?   A . n 
A 1 9   GLN 9   3   ?   ?   ?   A . n 
A 1 10  LYS 10  4   ?   ?   ?   A . n 
A 1 11  MET 11  5   ?   ?   ?   A . n 
A 1 12  ASP 12  6   6   ASP ASP A . n 
A 1 13  PHE 13  7   7   PHE PHE A . n 
A 1 14  ASP 14  8   8   ASP ASP A . n 
A 1 15  ALA 15  9   9   ALA ALA A . n 
A 1 16  ILE 16  10  10  ILE ILE A . n 
A 1 17  ILE 17  11  11  ILE ILE A . n 
A 1 18  ILE 18  12  12  ILE ILE A . n 
A 1 19  GLY 19  13  13  GLY GLY A . n 
A 1 20  ALA 20  14  14  ALA ALA A . n 
A 1 21  GLY 21  15  15  GLY GLY A . n 
A 1 22  PHE 22  16  16  PHE PHE A . n 
A 1 23  GLY 23  17  17  GLY GLY A . n 
A 1 24  GLY 24  18  18  GLY GLY A . n 
A 1 25  LEU 25  19  19  LEU LEU A . n 
A 1 26  TYR 26  20  20  TYR TYR A . n 
A 1 27  SER 27  21  21  SER SER A . n 
A 1 28  LEU 28  22  22  LEU LEU A . n 
A 1 29  LYS 29  23  23  LYS LYS A . n 
A 1 30  LYS 30  24  24  LYS LYS A . n 
A 1 31  LEU 31  25  25  LEU LEU A . n 
A 1 32  ARG 32  26  26  ARG ARG A . n 
A 1 33  ASP 33  27  27  ASP ASP A . n 
A 1 34  ASP 34  28  28  ASP ASP A . n 
A 1 35  PHE 35  29  29  PHE PHE A . n 
A 1 36  ASN 36  30  30  ASN ASN A . n 
A 1 37  LEU 37  31  31  LEU LEU A . n 
A 1 38  LYS 38  32  32  LYS LYS A . n 
A 1 39  VAL 39  33  33  VAL VAL A . n 
A 1 40  ARG 40  34  34  ARG ARG A . n 
A 1 41  ALA 41  35  35  ALA ALA A . n 
A 1 42  PHE 42  36  36  PHE PHE A . n 
A 1 43  ASP 43  37  37  ASP ASP A . n 
A 1 44  ARG 44  38  38  ARG ARG A . n 
A 1 45  ALA 45  39  39  ALA ALA A . n 
A 1 46  THR 46  40  40  THR THR A . n 
A 1 47  GLU 47  41  41  GLU GLU A . n 
A 1 48  VAL 48  42  42  VAL VAL A . n 
A 1 49  GLY 49  43  43  GLY GLY A . n 
A 1 50  GLY 50  44  44  GLY GLY A . n 
A 1 51  THR 51  45  45  THR THR A . n 
A 1 52  TRP 52  46  46  TRP TRP A . n 
A 1 53  PHE 53  47  47  PHE PHE A . n 
A 1 54  TRP 54  48  48  TRP TRP A . n 
A 1 55  ASN 55  49  49  ASN ASN A . n 
A 1 56  GLN 56  50  50  GLN GLN A . n 
A 1 57  TYR 57  51  51  TYR TYR A . n 
A 1 58  PRO 58  52  52  PRO PRO A . n 
A 1 59  GLY 59  53  53  GLY GLY A . n 
A 1 60  ALA 60  54  54  ALA ALA A . n 
A 1 61  LEU 61  55  55  LEU LEU A . n 
A 1 62  SER 62  56  56  SER SER A . n 
A 1 63  ASP 63  57  57  ASP ASP A . n 
A 1 64  SER 64  58  58  SER SER A . n 
A 1 65  GLU 65  59  59  GLU GLU A . n 
A 1 66  THR 66  60  60  THR THR A . n 
A 1 67  HIS 67  61  61  HIS HIS A . n 
A 1 68  LEU 68  62  62  LEU LEU A . n 
A 1 69  TYR 69  63  63  TYR TYR A . n 
A 1 70  CYS 70  64  64  CYS CYS A . n 
A 1 71  TYR 71  65  65  TYR TYR A . n 
A 1 72  SER 72  66  66  SER SER A . n 
A 1 73  TRP 73  67  67  TRP TRP A . n 
A 1 74  ASP 74  68  68  ASP ASP A . n 
A 1 75  LYS 75  69  69  LYS LYS A . n 
A 1 76  GLU 76  70  70  GLU GLU A . n 
A 1 77  LEU 77  71  71  LEU LEU A . n 
A 1 78  LEU 78  72  72  LEU LEU A . n 
A 1 79  GLN 79  73  73  GLN GLN A . n 
A 1 80  GLU 80  74  74  GLU GLU A . n 
A 1 81  MET 81  75  75  MET MET A . n 
A 1 82  GLU 82  76  76  GLU GLU A . n 
A 1 83  ILE 83  77  77  ILE ILE A . n 
A 1 84  LYS 84  78  78  LYS LYS A . n 
A 1 85  ARG 85  79  79  ARG ARG A . n 
A 1 86  LYS 86  80  80  LYS LYS A . n 
A 1 87  TYR 87  81  81  TYR TYR A . n 
A 1 88  ILE 88  82  82  ILE ILE A . n 
A 1 89  SER 89  83  83  SER SER A . n 
A 1 90  GLN 90  84  84  GLN GLN A . n 
A 1 91  PRO 91  85  85  PRO PRO A . n 
A 1 92  ASP 92  86  86  ASP ASP A . n 
A 1 93  VAL 93  87  87  VAL VAL A . n 
A 1 94  LEU 94  88  88  LEU LEU A . n 
A 1 95  ALA 95  89  89  ALA ALA A . n 
A 1 96  TYR 96  90  90  TYR TYR A . n 
A 1 97  LEU 97  91  91  LEU LEU A . n 
A 1 98  LYS 98  92  92  LYS LYS A . n 
A 1 99  ARG 99  93  93  ARG ARG A . n 
A 1 100 VAL 100 94  94  VAL VAL A . n 
A 1 101 ALA 101 95  95  ALA ALA A . n 
A 1 102 ASP 102 96  96  ASP ASP A . n 
A 1 103 LYS 103 97  97  LYS LYS A . n 
A 1 104 HIS 104 98  98  HIS HIS A . n 
A 1 105 ASP 105 99  99  ASP ASP A . n 
A 1 106 LEU 106 100 100 LEU LEU A . n 
A 1 107 ARG 107 101 101 ARG ARG A . n 
A 1 108 LYS 108 102 102 LYS LYS A . n 
A 1 109 ASP 109 103 103 ASP ASP A . n 
A 1 110 ILE 110 104 104 ILE ILE A . n 
A 1 111 GLN 111 105 105 GLN GLN A . n 
A 1 112 PHE 112 106 106 PHE PHE A . n 
A 1 113 GLU 113 107 107 GLU GLU A . n 
A 1 114 THR 114 108 108 THR THR A . n 
A 1 115 GLY 115 109 109 GLY GLY A . n 
A 1 116 ILE 116 110 110 ILE ILE A . n 
A 1 117 ARG 117 111 111 ARG ARG A . n 
A 1 118 SER 118 112 112 SER SER A . n 
A 1 119 ALA 119 113 113 ALA ALA A . n 
A 1 120 TYR 120 114 114 TYR TYR A . n 
A 1 121 PHE 121 115 115 PHE PHE A . n 
A 1 122 ASP 122 116 116 ASP ASP A . n 
A 1 123 GLU 123 117 117 GLU GLU A . n 
A 1 124 GLU 124 118 118 GLU GLU A . n 
A 1 125 ASN 125 119 119 ASN ASN A . n 
A 1 126 SER 126 120 120 SER SER A . n 
A 1 127 PHE 127 121 121 PHE PHE A . n 
A 1 128 TRP 128 122 122 TRP TRP A . n 
A 1 129 ASN 129 123 123 ASN ASN A . n 
A 1 130 VAL 130 124 124 VAL VAL A . n 
A 1 131 THR 131 125 125 THR THR A . n 
A 1 132 THR 132 126 126 THR THR A . n 
A 1 133 GLU 133 127 127 GLU GLU A . n 
A 1 134 ASN 134 128 128 ASN ASN A . n 
A 1 135 ASP 135 129 129 ASP ASP A . n 
A 1 136 GLU 136 130 130 GLU GLU A . n 
A 1 137 LYS 137 131 131 LYS LYS A . n 
A 1 138 PHE 138 132 132 PHE PHE A . n 
A 1 139 THR 139 133 133 THR THR A . n 
A 1 140 ALA 140 134 134 ALA ALA A . n 
A 1 141 ARG 141 135 135 ARG ARG A . n 
A 1 142 PHE 142 136 136 PHE PHE A . n 
A 1 143 LEU 143 137 137 LEU LEU A . n 
A 1 144 ILE 144 138 138 ILE ILE A . n 
A 1 145 THR 145 139 139 THR THR A . n 
A 1 146 ALA 146 140 140 ALA ALA A . n 
A 1 147 LEU 147 141 141 LEU LEU A . n 
A 1 148 GLY 148 142 142 GLY GLY A . n 
A 1 149 PRO 149 143 143 PRO PRO A . n 
A 1 150 LEU 150 144 144 LEU LEU A . n 
A 1 151 ALA 151 145 145 ALA ALA A . n 
A 1 152 ALA 152 146 146 ALA ALA A . n 
A 1 153 PRO 153 147 147 PRO PRO A . n 
A 1 154 ASN 154 148 148 ASN ASN A . n 
A 1 155 LEU 155 149 149 LEU LEU A . n 
A 1 156 PRO 156 150 150 PRO PRO A . n 
A 1 157 LYS 157 151 151 LYS LYS A . n 
A 1 158 ILE 158 152 152 ILE ILE A . n 
A 1 159 LYS 159 153 153 LYS LYS A . n 
A 1 160 GLY 160 154 154 GLY GLY A . n 
A 1 161 ILE 161 155 155 ILE ILE A . n 
A 1 162 GLU 162 156 156 GLU GLU A . n 
A 1 163 THR 163 157 157 THR THR A . n 
A 1 164 PHE 164 158 158 PHE PHE A . n 
A 1 165 LYS 165 159 159 LYS LYS A . n 
A 1 166 GLY 166 160 160 GLY GLY A . n 
A 1 167 GLU 167 161 161 GLU GLU A . n 
A 1 168 LEU 168 162 162 LEU LEU A . n 
A 1 169 HIS 169 163 163 HIS HIS A . n 
A 1 170 HIS 170 164 164 HIS HIS A . n 
A 1 171 THR 171 165 165 THR THR A . n 
A 1 172 SER 172 166 166 SER SER A . n 
A 1 173 ARG 173 167 167 ARG ARG A . n 
A 1 174 TRP 174 168 168 TRP TRP A . n 
A 1 175 PRO 175 169 169 PRO PRO A . n 
A 1 176 LYS 176 170 170 LYS LYS A . n 
A 1 177 ASP 177 171 171 ASP ASP A . n 
A 1 178 VAL 178 172 172 VAL VAL A . n 
A 1 179 THR 179 173 173 THR THR A . n 
A 1 180 PHE 180 174 174 PHE PHE A . n 
A 1 181 SER 181 175 175 SER SER A . n 
A 1 182 GLY 182 176 176 GLY GLY A . n 
A 1 183 LYS 183 177 177 LYS LYS A . n 
A 1 184 ARG 184 178 178 ARG ARG A . n 
A 1 185 VAL 185 179 179 VAL VAL A . n 
A 1 186 GLY 186 180 180 GLY GLY A . n 
A 1 187 VAL 187 181 181 VAL VAL A . n 
A 1 188 ILE 188 182 182 ILE ILE A . n 
A 1 189 GLY 189 183 183 GLY GLY A . n 
A 1 190 THR 190 184 184 THR THR A . n 
A 1 191 GLY 191 185 185 GLY GLY A . n 
A 1 192 SER 192 186 186 SER SER A . n 
A 1 193 THR 193 187 187 THR THR A . n 
A 1 194 GLY 194 188 188 GLY GLY A . n 
A 1 195 VAL 195 189 189 VAL VAL A . n 
A 1 196 GLN 196 190 190 GLN GLN A . n 
A 1 197 VAL 197 191 191 VAL VAL A . n 
A 1 198 ILE 198 192 192 ILE ILE A . n 
A 1 199 THR 199 193 193 THR THR A . n 
A 1 200 ALA 200 194 194 ALA ALA A . n 
A 1 201 ILE 201 195 195 ILE ILE A . n 
A 1 202 ALA 202 196 196 ALA ALA A . n 
A 1 203 SER 203 197 197 SER SER A . n 
A 1 204 GLN 204 198 198 GLN GLN A . n 
A 1 205 VAL 205 199 199 VAL VAL A . n 
A 1 206 LYS 206 200 200 LYS LYS A . n 
A 1 207 HIS 207 201 201 HIS HIS A . n 
A 1 208 LEU 208 202 202 LEU LEU A . n 
A 1 209 THR 209 203 203 THR THR A . n 
A 1 210 VAL 210 204 204 VAL VAL A . n 
A 1 211 PHE 211 205 205 PHE PHE A . n 
A 1 212 GLN 212 206 206 GLN GLN A . n 
A 1 213 ARG 213 207 207 ARG ARG A . n 
A 1 214 SER 214 208 208 SER SER A . n 
A 1 215 ALA 215 209 209 ALA ALA A . n 
A 1 216 GLN 216 210 210 GLN GLN A . n 
A 1 217 TYR 217 211 211 TYR TYR A . n 
A 1 218 SER 218 212 212 SER SER A . n 
A 1 219 VAL 219 213 213 VAL VAL A . n 
A 1 220 PRO 220 214 214 PRO PRO A . n 
A 1 221 ILE 221 215 215 ILE ILE A . n 
A 1 222 GLY 222 216 216 GLY GLY A . n 
A 1 223 ASN 223 217 217 ASN ASN A . n 
A 1 224 VAL 224 218 218 VAL VAL A . n 
A 1 225 VAL 225 219 219 VAL VAL A . n 
A 1 226 MET 226 220 220 MET MET A . n 
A 1 227 SER 227 221 221 SER SER A . n 
A 1 228 GLU 228 222 222 GLU GLU A . n 
A 1 229 THR 229 223 223 THR THR A . n 
A 1 230 ASP 230 224 224 ASP ASP A . n 
A 1 231 VAL 231 225 225 VAL VAL A . n 
A 1 232 ALA 232 226 226 ALA ALA A . n 
A 1 233 LYS 233 227 227 LYS LYS A . n 
A 1 234 ILE 234 228 228 ILE ILE A . n 
A 1 235 LYS 235 229 229 LYS LYS A . n 
A 1 236 GLU 236 230 230 GLU GLU A . n 
A 1 237 ASN 237 231 231 ASN ASN A . n 
A 1 238 TYR 238 232 232 TYR TYR A . n 
A 1 239 ASP 239 233 233 ASP ASP A . n 
A 1 240 GLN 240 234 234 GLN GLN A . n 
A 1 241 ILE 241 235 235 ILE ILE A . n 
A 1 242 TRP 242 236 236 TRP TRP A . n 
A 1 243 GLU 243 237 237 GLU GLU A . n 
A 1 244 ASN 244 238 238 ASN ASN A . n 
A 1 245 VAL 245 239 239 VAL VAL A . n 
A 1 246 TRP 246 240 240 TRP TRP A . n 
A 1 247 ASN 247 241 241 ASN ASN A . n 
A 1 248 SER 248 242 242 SER SER A . n 
A 1 249 ALA 249 243 243 ALA ALA A . n 
A 1 250 LEU 250 244 244 LEU LEU A . n 
A 1 251 GLY 251 245 245 GLY GLY A . n 
A 1 252 TYR 252 246 246 TYR TYR A . n 
A 1 253 GLY 253 247 247 GLY GLY A . n 
A 1 254 LEU 254 248 248 LEU LEU A . n 
A 1 255 ASN 255 249 249 ASN ASN A . n 
A 1 256 GLU 256 250 250 GLU GLU A . n 
A 1 257 SER 257 251 251 SER SER A . n 
A 1 258 THR 258 252 252 THR THR A . n 
A 1 259 LEU 259 253 253 LEU LEU A . n 
A 1 260 PRO 260 254 254 PRO PRO A . n 
A 1 261 THR 261 255 255 THR THR A . n 
A 1 262 MET 262 256 256 MET MET A . n 
A 1 263 SER 263 257 257 SER SER A . n 
A 1 264 VAL 264 258 258 VAL VAL A . n 
A 1 265 SER 265 259 259 SER SER A . n 
A 1 266 ALA 266 260 260 ALA ALA A . n 
A 1 267 GLU 267 261 261 GLU GLU A . n 
A 1 268 GLU 268 262 262 GLU GLU A . n 
A 1 269 ARG 269 263 263 ARG ARG A . n 
A 1 270 ASP 270 264 264 ASP ASP A . n 
A 1 271 LYS 271 265 265 LYS LYS A . n 
A 1 272 ILE 272 266 266 ILE ILE A . n 
A 1 273 PHE 273 267 267 PHE PHE A . n 
A 1 274 GLU 274 268 268 GLU GLU A . n 
A 1 275 LYS 275 269 269 LYS LYS A . n 
A 1 276 ALA 276 270 270 ALA ALA A . n 
A 1 277 TRP 277 271 271 TRP TRP A . n 
A 1 278 GLN 278 272 272 GLN GLN A . n 
A 1 279 GLU 279 273 273 GLU GLU A . n 
A 1 280 GLY 280 274 274 GLY GLY A . n 
A 1 281 GLY 281 275 275 GLY GLY A . n 
A 1 282 GLY 282 276 276 GLY GLY A . n 
A 1 283 PHE 283 277 277 PHE PHE A . n 
A 1 284 ARG 284 278 278 ARG ARG A . n 
A 1 285 PHE 285 279 279 PHE PHE A . n 
A 1 286 MET 286 280 280 MET MET A . n 
A 1 287 PHE 287 281 281 PHE PHE A . n 
A 1 288 GLU 288 282 282 GLU GLU A . n 
A 1 289 THR 289 283 283 THR THR A . n 
A 1 290 PHE 290 284 284 PHE PHE A . n 
A 1 291 GLY 291 285 285 GLY GLY A . n 
A 1 292 ASP 292 286 286 ASP ASP A . n 
A 1 293 ILE 293 287 287 ILE ILE A . n 
A 1 294 ALA 294 288 288 ALA ALA A . n 
A 1 295 VAL 295 289 289 VAL VAL A . n 
A 1 296 ASP 296 290 290 ASP ASP A . n 
A 1 297 GLU 297 291 291 GLU GLU A . n 
A 1 298 THR 298 292 292 THR THR A . n 
A 1 299 ALA 299 293 293 ALA ALA A . n 
A 1 300 ASN 300 294 294 ASN ASN A . n 
A 1 301 ILE 301 295 295 ILE ILE A . n 
A 1 302 GLU 302 296 296 GLU GLU A . n 
A 1 303 ALA 303 297 297 ALA ALA A . n 
A 1 304 GLN 304 298 298 GLN GLN A . n 
A 1 305 ASN 305 299 299 ASN ASN A . n 
A 1 306 PHE 306 300 300 PHE PHE A . n 
A 1 307 ILE 307 301 301 ILE ILE A . n 
A 1 308 LYS 308 302 302 LYS LYS A . n 
A 1 309 LYS 309 303 303 LYS LYS A . n 
A 1 310 LYS 310 304 304 LYS LYS A . n 
A 1 311 ILE 311 305 305 ILE ILE A . n 
A 1 312 SER 312 306 306 SER SER A . n 
A 1 313 GLU 313 307 307 GLU GLU A . n 
A 1 314 ILE 314 308 308 ILE ILE A . n 
A 1 315 VAL 315 309 309 VAL VAL A . n 
A 1 316 LYS 316 310 310 LYS LYS A . n 
A 1 317 ASP 317 311 311 ASP ASP A . n 
A 1 318 PRO 318 312 312 PRO PRO A . n 
A 1 319 PHE 319 313 313 PHE PHE A . n 
A 1 320 VAL 320 314 314 VAL VAL A . n 
A 1 321 ALA 321 315 315 ALA ALA A . n 
A 1 322 LYS 322 316 316 LYS LYS A . n 
A 1 323 LYS 323 317 317 LYS LYS A . n 
A 1 324 LEU 324 318 318 LEU LEU A . n 
A 1 325 THR 325 319 319 THR THR A . n 
A 1 326 PRO 326 320 320 PRO PRO A . n 
A 1 327 THR 327 321 321 THR THR A . n 
A 1 328 ASP 328 322 322 ASP ASP A . n 
A 1 329 LEU 329 323 323 LEU LEU A . n 
A 1 330 TYR 330 324 324 TYR TYR A . n 
A 1 331 ALA 331 325 325 ALA ALA A . n 
A 1 332 CYS 332 326 326 CYS CYS A . n 
A 1 333 ARG 333 327 327 ARG ARG A . n 
A 1 334 PRO 334 328 328 PRO PRO A . n 
A 1 335 LEU 335 329 329 LEU LEU A . n 
A 1 336 CYS 336 330 330 CYS CYS A . n 
A 1 337 ASP 337 331 331 ASP ASP A . n 
A 1 338 SER 338 332 332 SER SER A . n 
A 1 339 GLY 339 333 333 GLY GLY A . n 
A 1 340 TYR 340 334 334 TYR TYR A . n 
A 1 341 TYR 341 335 335 TYR TYR A . n 
A 1 342 GLU 342 336 336 GLU GLU A . n 
A 1 343 ILE 343 337 337 ILE ILE A . n 
A 1 344 PHE 344 338 338 PHE PHE A . n 
A 1 345 ASN 345 339 339 ASN ASN A . n 
A 1 346 ARG 346 340 340 ARG ARG A . n 
A 1 347 ASP 347 341 341 ASP ASP A . n 
A 1 348 ASN 348 342 342 ASN ASN A . n 
A 1 349 VAL 349 343 343 VAL VAL A . n 
A 1 350 SER 350 344 344 SER SER A . n 
A 1 351 LEU 351 345 345 LEU LEU A . n 
A 1 352 GLU 352 346 346 GLU GLU A . n 
A 1 353 ASP 353 347 347 ASP ASP A . n 
A 1 354 VAL 354 348 348 VAL VAL A . n 
A 1 355 LYS 355 349 349 LYS LYS A . n 
A 1 356 ALA 356 350 350 ALA ALA A . n 
A 1 357 ASN 357 351 351 ASN ASN A . n 
A 1 358 PRO 358 352 352 PRO PRO A . n 
A 1 359 ILE 359 353 353 ILE ILE A . n 
A 1 360 VAL 360 354 354 VAL VAL A . n 
A 1 361 GLU 361 355 355 GLU GLU A . n 
A 1 362 ILE 362 356 356 ILE ILE A . n 
A 1 363 LYS 363 357 357 LYS LYS A . n 
A 1 364 GLU 364 358 358 GLU GLU A . n 
A 1 365 ASP 365 359 359 ASP ASP A . n 
A 1 366 CYS 366 360 360 CYS CYS A . n 
A 1 367 VAL 367 361 361 VAL VAL A . n 
A 1 368 VAL 368 362 362 VAL VAL A . n 
A 1 369 THR 369 363 363 THR THR A . n 
A 1 370 ALA 370 364 364 ALA ALA A . n 
A 1 371 ASP 371 365 365 ASP ASP A . n 
A 1 372 GLY 372 366 366 GLY GLY A . n 
A 1 373 VAL 373 367 367 VAL VAL A . n 
A 1 374 GLU 374 368 368 GLU GLU A . n 
A 1 375 HIS 375 369 369 HIS HIS A . n 
A 1 376 LYS 376 370 370 LYS LYS A . n 
A 1 377 LEU 377 371 371 LEU LEU A . n 
A 1 378 ASP 378 372 372 ASP ASP A . n 
A 1 379 MET 379 373 373 MET MET A . n 
A 1 380 LEU 380 374 374 LEU LEU A . n 
A 1 381 ILE 381 375 375 ILE ILE A . n 
A 1 382 CYS 382 376 376 CYS CYS A . n 
A 1 383 ALA 383 377 377 ALA ALA A . n 
A 1 384 THR 384 378 378 THR THR A . n 
A 1 385 GLY 385 379 379 GLY GLY A . n 
A 1 386 PHE 386 380 380 PHE PHE A . n 
A 1 387 ASP 387 381 381 ASP ASP A . n 
A 1 388 ALA 388 382 382 ALA ALA A . n 
A 1 389 VAL 389 383 383 VAL VAL A . n 
A 1 390 ASP 390 384 384 ASP ASP A . n 
A 1 391 GLY 391 385 385 GLY GLY A . n 
A 1 392 SER 392 386 386 SER SER A . n 
A 1 393 TYR 393 387 387 TYR TYR A . n 
A 1 394 LYS 394 388 388 LYS LYS A . n 
A 1 395 ARG 395 389 389 ARG ARG A . n 
A 1 396 ILE 396 390 390 ILE ILE A . n 
A 1 397 ASP 397 391 391 ASP ASP A . n 
A 1 398 ILE 398 392 392 ILE ILE A . n 
A 1 399 ARG 399 393 393 ARG ARG A . n 
A 1 400 GLY 400 394 394 GLY GLY A . n 
A 1 401 LYS 401 395 395 LYS LYS A . n 
A 1 402 ASP 402 396 396 ASP ASP A . n 
A 1 403 GLY 403 397 397 GLY GLY A . n 
A 1 404 ILE 404 398 398 ILE ILE A . n 
A 1 405 SER 405 399 399 SER SER A . n 
A 1 406 ILE 406 400 400 ILE ILE A . n 
A 1 407 LYS 407 401 401 LYS LYS A . n 
A 1 408 ASP 408 402 402 ASP ASP A . n 
A 1 409 HIS 409 403 403 HIS HIS A . n 
A 1 410 TRP 410 404 404 TRP TRP A . n 
A 1 411 LYS 411 405 405 LYS LYS A . n 
A 1 412 ASP 412 406 406 ASP ASP A . n 
A 1 413 GLY 413 407 407 GLY GLY A . n 
A 1 414 PRO 414 408 408 PRO PRO A . n 
A 1 415 ASN 415 409 409 ASN ASN A . n 
A 1 416 SER 416 410 410 SER SER A . n 
A 1 417 TYR 417 411 411 TYR TYR A . n 
A 1 418 LEU 418 412 412 LEU LEU A . n 
A 1 419 GLY 419 413 413 GLY GLY A . n 
A 1 420 MET 420 414 414 MET MET A . n 
A 1 421 MET 421 415 415 MET MET A . n 
A 1 422 VAL 422 416 416 VAL VAL A . n 
A 1 423 SER 423 417 417 SER SER A . n 
A 1 424 ASN 424 418 418 ASN ASN A . n 
A 1 425 PHE 425 419 419 PHE PHE A . n 
A 1 426 PRO 426 420 420 PRO PRO A . n 
A 1 427 ASN 427 421 421 ASN ASN A . n 
A 1 428 MET 428 422 422 MET MET A . n 
A 1 429 PHE 429 423 423 PHE PHE A . n 
A 1 430 MET 430 424 424 MET MET A . n 
A 1 431 VAL 431 425 425 VAL VAL A . n 
A 1 432 PHE 432 426 426 PHE PHE A . n 
A 1 433 GLY 433 427 427 GLY GLY A . n 
A 1 434 PRO 434 428 428 PRO PRO A . n 
A 1 435 ASN 435 429 429 ASN ASN A . n 
A 1 436 GLY 436 430 430 GLY GLY A . n 
A 1 437 PRO 437 431 431 PRO PRO A . n 
A 1 438 LEU 438 432 432 LEU LEU A . n 
A 1 439 ALA 439 433 433 ALA ALA A . n 
A 1 440 ASN 440 434 434 ASN ASN A . n 
A 1 441 SER 441 435 435 SER SER A . n 
A 1 442 PRO 442 436 436 PRO PRO A . n 
A 1 443 PRO 443 437 437 PRO PRO A . n 
A 1 444 ILE 444 438 438 ILE ILE A . n 
A 1 445 ILE 445 439 439 ILE ILE A . n 
A 1 446 GLU 446 440 440 GLU GLU A . n 
A 1 447 THR 447 441 441 THR THR A . n 
A 1 448 GLN 448 442 442 GLN GLN A . n 
A 1 449 VAL 449 443 443 VAL VAL A . n 
A 1 450 ARG 450 444 444 ARG ARG A . n 
A 1 451 TRP 451 445 445 TRP TRP A . n 
A 1 452 ILE 452 446 446 ILE ILE A . n 
A 1 453 ALA 453 447 447 ALA ALA A . n 
A 1 454 ASP 454 448 448 ASP ASP A . n 
A 1 455 LEU 455 449 449 LEU LEU A . n 
A 1 456 ILE 456 450 450 ILE ILE A . n 
A 1 457 GLY 457 451 451 GLY GLY A . n 
A 1 458 TYR 458 452 452 TYR TYR A . n 
A 1 459 ALA 459 453 453 ALA ALA A . n 
A 1 460 GLU 460 454 454 GLU GLU A . n 
A 1 461 ASP 461 455 455 ASP ASP A . n 
A 1 462 HIS 462 456 456 HIS HIS A . n 
A 1 463 GLN 463 457 457 GLN GLN A . n 
A 1 464 ILE 464 458 458 ILE ILE A . n 
A 1 465 ASN 465 459 459 ASN ASN A . n 
A 1 466 GLN 466 460 460 GLN GLN A . n 
A 1 467 ILE 467 461 461 ILE ILE A . n 
A 1 468 GLU 468 462 462 GLU GLU A . n 
A 1 469 ALA 469 463 463 ALA ALA A . n 
A 1 470 THR 470 464 464 THR THR A . n 
A 1 471 LYS 471 465 465 LYS LYS A . n 
A 1 472 ASP 472 466 466 ASP ASP A . n 
A 1 473 ALA 473 467 467 ALA ALA A . n 
A 1 474 VAL 474 468 468 VAL VAL A . n 
A 1 475 ASP 475 469 469 ASP ASP A . n 
A 1 476 ASN 476 470 470 ASN ASN A . n 
A 1 477 TRP 477 471 471 TRP TRP A . n 
A 1 478 THR 478 472 472 THR THR A . n 
A 1 479 ASN 479 473 473 ASN ASN A . n 
A 1 480 THR 480 474 474 THR THR A . n 
A 1 481 CYS 481 475 475 CYS CYS A . n 
A 1 482 SER 482 476 476 SER SER A . n 
A 1 483 ASP 483 477 477 ASP ASP A . n 
A 1 484 ILE 484 478 478 ILE ILE A . n 
A 1 485 ALA 485 479 479 ALA ALA A . n 
A 1 486 ASN 486 480 480 ASN ASN A . n 
A 1 487 LYS 487 481 481 LYS LYS A . n 
A 1 488 THR 488 482 482 THR THR A . n 
A 1 489 LEU 489 483 483 LEU LEU A . n 
A 1 490 PHE 490 484 484 PHE PHE A . n 
A 1 491 ALA 491 485 485 ALA ALA A . n 
A 1 492 LYS 492 486 486 LYS LYS A . n 
A 1 493 ALA 493 487 487 ALA ALA A . n 
A 1 494 LYS 494 488 488 LYS LYS A . n 
A 1 495 CYS 495 489 489 CYS CYS A . n 
A 1 496 ARG 496 490 ?   ?   ?   A . n 
A 1 497 ILE 497 491 ?   ?   ?   A . n 
A 1 498 PHE 498 492 ?   ?   ?   A . n 
A 1 499 GLY 499 493 ?   ?   ?   A . n 
A 1 500 ALA 500 494 ?   ?   ?   A . n 
A 1 501 ASN 501 495 ?   ?   ?   A . n 
A 1 502 VAL 502 496 ?   ?   ?   A . n 
A 1 503 PRO 503 497 ?   ?   ?   A . n 
A 1 504 GLY 504 498 ?   ?   ?   A . n 
A 1 505 LYS 505 499 ?   ?   ?   A . n 
A 1 506 LYS 506 500 ?   ?   ?   A . n 
A 1 507 ASN 507 501 ?   ?   ?   A . n 
A 1 508 THR 508 502 ?   ?   ?   A . n 
A 1 509 VAL 509 503 503 VAL VAL A . n 
A 1 510 TYR 510 504 504 TYR TYR A . n 
A 1 511 LEU 511 505 505 LEU LEU A . n 
A 1 512 TYR 512 506 506 TYR TYR A . n 
A 1 513 MET 513 507 507 MET MET A . n 
A 1 514 GLY 514 508 508 GLY GLY A . n 
A 1 515 GLY 515 509 509 GLY GLY A . n 
A 1 516 LEU 516 510 510 LEU LEU A . n 
A 1 517 LYS 517 511 511 LYS LYS A . n 
A 1 518 GLU 518 512 512 GLU GLU A . n 
A 1 519 TYR 519 513 513 TYR TYR A . n 
A 1 520 ARG 520 514 514 ARG ARG A . n 
A 1 521 ASN 521 515 515 ASN ASN A . n 
A 1 522 GLN 522 516 516 GLN GLN A . n 
A 1 523 ILE 523 517 517 ILE ILE A . n 
A 1 524 SER 524 518 518 SER SER A . n 
A 1 525 GLU 525 519 519 GLU GLU A . n 
A 1 526 VAL 526 520 520 VAL VAL A . n 
A 1 527 SER 527 521 521 SER SER A . n 
A 1 528 ASN 528 522 522 ASN ASN A . n 
A 1 529 ASN 529 523 523 ASN ASN A . n 
A 1 530 ASN 530 524 524 ASN ASN A . n 
A 1 531 TYR 531 525 525 TYR TYR A . n 
A 1 532 LYS 532 526 526 LYS LYS A . n 
A 1 533 GLY 533 527 527 GLY GLY A . n 
A 1 534 CYS 534 528 528 CYS CYS A . n 
A 1 535 LEU 535 529 529 LEU LEU A . n 
A 1 536 LEU 536 530 530 LEU LEU A . n 
A 1 537 LYS 537 531 531 LYS LYS A . n 
A 1 538 GLN 538 532 532 GLN GLN A . n 
A 1 539 SER 539 533 533 SER SER A . n 
A 1 540 VAL 540 534 ?   ?   ?   A . n 
A 1 541 LYS 541 535 ?   ?   ?   A . n 
A 1 542 LYS 542 536 ?   ?   ?   A . n 
A 1 543 THR 543 537 ?   ?   ?   A . n 
A 1 544 ASN 544 538 ?   ?   ?   A . n 
A 1 545 LEU 545 539 ?   ?   ?   A . n 
A 1 546 ILE 546 540 ?   ?   ?   A . n 
A 1 547 GLU 547 541 ?   ?   ?   A . n 
A 1 548 SER 548 542 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 FAD ? ? FAD ? ? 'SUBJECT OF INVESTIGATION' ? 
2 NAD ? ? NAD ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 FAD 1   601 601 FAD FAD A . 
C 3 NAD 1   602 602 NAD NAD A . 
D 4 HOH 1   701 5   HOH HOH A . 
D 4 HOH 2   702 61  HOH HOH A . 
D 4 HOH 3   703 44  HOH HOH A . 
D 4 HOH 4   704 9   HOH HOH A . 
D 4 HOH 5   705 27  HOH HOH A . 
D 4 HOH 6   706 12  HOH HOH A . 
D 4 HOH 7   707 35  HOH HOH A . 
D 4 HOH 8   708 15  HOH HOH A . 
D 4 HOH 9   709 26  HOH HOH A . 
D 4 HOH 10  710 10  HOH HOH A . 
D 4 HOH 11  711 47  HOH HOH A . 
D 4 HOH 12  712 51  HOH HOH A . 
D 4 HOH 13  713 89  HOH HOH A . 
D 4 HOH 14  714 21  HOH HOH A . 
D 4 HOH 15  715 6   HOH HOH A . 
D 4 HOH 16  716 63  HOH HOH A . 
D 4 HOH 17  717 18  HOH HOH A . 
D 4 HOH 18  718 7   HOH HOH A . 
D 4 HOH 19  719 1   HOH HOH A . 
D 4 HOH 20  720 39  HOH HOH A . 
D 4 HOH 21  721 14  HOH HOH A . 
D 4 HOH 22  722 72  HOH HOH A . 
D 4 HOH 23  723 41  HOH HOH A . 
D 4 HOH 24  724 63  HOH HOH A . 
D 4 HOH 25  725 79  HOH HOH A . 
D 4 HOH 26  726 31  HOH HOH A . 
D 4 HOH 27  727 65  HOH HOH A . 
D 4 HOH 28  728 36  HOH HOH A . 
D 4 HOH 29  729 78  HOH HOH A . 
D 4 HOH 30  730 11  HOH HOH A . 
D 4 HOH 31  731 60  HOH HOH A . 
D 4 HOH 32  732 4   HOH HOH A . 
D 4 HOH 33  733 2   HOH HOH A . 
D 4 HOH 34  734 42  HOH HOH A . 
D 4 HOH 35  735 77  HOH HOH A . 
D 4 HOH 36  736 84  HOH HOH A . 
D 4 HOH 37  737 8   HOH HOH A . 
D 4 HOH 38  738 16  HOH HOH A . 
D 4 HOH 39  739 59  HOH HOH A . 
D 4 HOH 40  740 33  HOH HOH A . 
D 4 HOH 41  741 19  HOH HOH A . 
D 4 HOH 42  742 33  HOH HOH A . 
D 4 HOH 43  743 81  HOH HOH A . 
D 4 HOH 44  744 53  HOH HOH A . 
D 4 HOH 45  745 76  HOH HOH A . 
D 4 HOH 46  746 40  HOH HOH A . 
D 4 HOH 47  747 2   HOH HOH A . 
D 4 HOH 48  748 6   HOH HOH A . 
D 4 HOH 49  749 67  HOH HOH A . 
D 4 HOH 50  750 16  HOH HOH A . 
D 4 HOH 51  751 37  HOH HOH A . 
D 4 HOH 52  752 75  HOH HOH A . 
D 4 HOH 53  753 3   HOH HOH A . 
D 4 HOH 54  754 46  HOH HOH A . 
D 4 HOH 55  755 13  HOH HOH A . 
D 4 HOH 56  756 5   HOH HOH A . 
D 4 HOH 57  757 32  HOH HOH A . 
D 4 HOH 58  758 2   HOH HOH A . 
D 4 HOH 59  759 12  HOH HOH A . 
D 4 HOH 60  760 7   HOH HOH A . 
D 4 HOH 61  761 55  HOH HOH A . 
D 4 HOH 62  762 57  HOH HOH A . 
D 4 HOH 63  763 4   HOH HOH A . 
D 4 HOH 64  764 48  HOH HOH A . 
D 4 HOH 65  765 44  HOH HOH A . 
D 4 HOH 66  766 23  HOH HOH A . 
D 4 HOH 67  767 18  HOH HOH A . 
D 4 HOH 68  768 30  HOH HOH A . 
D 4 HOH 69  769 7   HOH HOH A . 
D 4 HOH 70  770 49  HOH HOH A . 
D 4 HOH 71  771 52  HOH HOH A . 
D 4 HOH 72  772 79  HOH HOH A . 
D 4 HOH 73  773 46  HOH HOH A . 
D 4 HOH 74  774 9   HOH HOH A . 
D 4 HOH 75  775 7   HOH HOH A . 
D 4 HOH 76  776 64  HOH HOH A . 
D 4 HOH 77  777 25  HOH HOH A . 
D 4 HOH 78  778 3   HOH HOH A . 
D 4 HOH 79  779 47  HOH HOH A . 
D 4 HOH 80  780 54  HOH HOH A . 
D 4 HOH 81  781 69  HOH HOH A . 
D 4 HOH 82  782 20  HOH HOH A . 
D 4 HOH 83  783 22  HOH HOH A . 
D 4 HOH 84  784 65  HOH HOH A . 
D 4 HOH 85  785 31  HOH HOH A . 
D 4 HOH 86  786 58  HOH HOH A . 
D 4 HOH 87  787 58  HOH HOH A . 
D 4 HOH 88  788 70  HOH HOH A . 
D 4 HOH 89  789 53  HOH HOH A . 
D 4 HOH 90  790 13  HOH HOH A . 
D 4 HOH 91  791 36  HOH HOH A . 
D 4 HOH 92  792 71  HOH HOH A . 
D 4 HOH 93  793 78  HOH HOH A . 
D 4 HOH 94  794 34  HOH HOH A . 
D 4 HOH 95  795 43  HOH HOH A . 
D 4 HOH 96  796 22  HOH HOH A . 
D 4 HOH 97  797 90  HOH HOH A . 
D 4 HOH 98  798 28  HOH HOH A . 
D 4 HOH 99  799 17  HOH HOH A . 
D 4 HOH 100 800 29  HOH HOH A . 
D 4 HOH 101 801 73  HOH HOH A . 
D 4 HOH 102 802 92  HOH HOH A . 
D 4 HOH 103 803 62  HOH HOH A . 
D 4 HOH 104 804 13  HOH HOH A . 
D 4 HOH 105 805 68  HOH HOH A . 
D 4 HOH 106 806 16  HOH HOH A . 
D 4 HOH 107 807 56  HOH HOH A . 
D 4 HOH 108 808 50  HOH HOH A . 
D 4 HOH 109 809 6   HOH HOH A . 
D 4 HOH 110 810 38  HOH HOH A . 
D 4 HOH 111 811 76  HOH HOH A . 
D 4 HOH 112 812 60  HOH HOH A . 
D 4 HOH 113 813 14  HOH HOH A . 
D 4 HOH 114 814 24  HOH HOH A . 
D 4 HOH 115 815 83  HOH HOH A . 
D 4 HOH 116 816 71  HOH HOH A . 
D 4 HOH 117 817 69  HOH HOH A . 
D 4 HOH 118 818 80  HOH HOH A . 
D 4 HOH 119 819 18  HOH HOH A . 
D 4 HOH 120 820 90  HOH HOH A . 
D 4 HOH 121 821 62  HOH HOH A . 
D 4 HOH 122 822 13  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   96.716 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YU2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     52.690 
_cell.length_a_esd                 ? 
_cell.length_b                     53.410 
_cell.length_b_esd                 ? 
_cell.length_c                     102.630 
_cell.length_c_esd                 ? 
_cell.volume                       286836.700 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YU2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YU2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.47 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.12 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.05 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M Tris (base)-Bicine pH 8.05; 20% (v/v) PEG 500*MME; 10% (w/v) PEG 20000; 0.2 M Monosaccharides (D-Glucose; D-Mannose; D-Galactose; L-Fucose; D-Xylose; N-Acetyl-D- Glucosamine)
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-08-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97918 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97918 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          75.15 
_reflns.entry_id                                       8YU2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.63 
_reflns.d_resolution_low                               38.85 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     17061 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.62 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.91 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1364 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.63 
_reflns_shell.d_res_low                                     2.724 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1666 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.342 
_reflns_shell.pdbx_CC_star                                  0.714 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.409 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               83.97 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YU2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.63 
_refine.ls_d_res_low                             38.85 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17052 
_refine.ls_number_reflns_R_free                  937 
_refine.ls_number_reflns_R_work                  16115 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.67 
_refine.ls_percent_reflns_R_free                 5.49 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2286 
_refine.ls_R_factor_R_free                       0.2748 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2258 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      6A37 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 36.3000 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.4844 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.63 
_refine_hist.d_res_low                        38.85 
_refine_hist.number_atoms_solvent             122 
_refine_hist.number_atoms_total               4313 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4094 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         97 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0024  ? 4292 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5980  ? 5827 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0429  ? 628  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0035  ? 737  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 17.4416 ? 591  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.63 2.77  . . 116 2303 99.59 . . . . 0.3682 . . . . . . . . . . . 0.4432 
'X-RAY DIFFRACTION' 2.77 2.94  . . 111 2294 99.71 . . . . 0.3203 . . . . . . . . . . . 0.3631 
'X-RAY DIFFRACTION' 2.94 3.17  . . 113 2286 99.79 . . . . 0.2980 . . . . . . . . . . . 0.3909 
'X-RAY DIFFRACTION' 3.17 3.49  . . 115 2328 99.71 . . . . 0.2494 . . . . . . . . . . . 0.3267 
'X-RAY DIFFRACTION' 3.49 3.99  . . 149 2278 99.92 . . . . 0.2287 . . . . . . . . . . . 0.3007 
'X-RAY DIFFRACTION' 3.99 5.03  . . 204 2245 99.55 . . . . 0.1817 . . . . . . . . . . . 0.2226 
'X-RAY DIFFRACTION' 5.03 38.85 . . 129 2381 99.41 . . . . 0.2064 . . . . . . . . . . . 0.2612 
# 
_struct.entry_id                     8YU2 
_struct.title                        'Structure of cyclohexanone monooxygenase mutant from Acinetobacter calcoaceticus' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YU2 
_struct_keywords.text            'Complex, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A0A8XFY0_ACICA 
_struct_ref.pdbx_db_accession          A0A0A8XFY0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;TQKMDFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGTWFWNQYPGALSDSETHLYCYSWDKELLQEMEIKRKY
ISQPDVLAYLKRVADKHDLRKDIQFETGIRSAYFDEENSFWNVTTENDEKFTARFLITALGLLAAPNLPKIKGIETFKGE
LHHTSRWPKDVTFSGKRVGVIGTGSTGVQVITAIASQVKHLTVFQRSAQYSVPIGNVVMSETDVAKIKENYDQIWENVWN
SALGFGLNESTLPTMSVSAEERDKIFEKAWQEGGGFRFMFETFGDIAVDETANIEAQNFIKKKISEIVKDPFVAKKLTPT
DLYAKRPLCDSGYYEIFNRDNVSLEDVKANPIVEIKEDCVVTADGVEHKLDMLICATGFDAVDGNYIRMDIRGKDGISIK
DHWKDGPNSYLGMMVSNFPNMFMVLGPNGPFTNLPPSIETQVRWIADLIGYAEDHQINQIEATKDAVDNWTNTCSDIANK
TLFAKAESWIFGANVPGKKNTVYFYMGGLKEYRNQISEVSNNNYKGCLLKQSVKKTNLIES
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YU2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 8 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 548 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A0A8XFY0 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YU2 MET A 1   ? UNP A0A0A8XFY0 ?   ?   'initiating methionine' -5  1  
1 8YU2 HIS A 2   ? UNP A0A0A8XFY0 ?   ?   'expression tag'        -4  2  
1 8YU2 HIS A 3   ? UNP A0A0A8XFY0 ?   ?   'expression tag'        -3  3  
1 8YU2 HIS A 4   ? UNP A0A0A8XFY0 ?   ?   'expression tag'        -2  4  
1 8YU2 HIS A 5   ? UNP A0A0A8XFY0 ?   ?   'expression tag'        -1  5  
1 8YU2 HIS A 6   ? UNP A0A0A8XFY0 ?   ?   'expression tag'        0   6  
1 8YU2 HIS A 7   ? UNP A0A0A8XFY0 ?   ?   'expression tag'        1   7  
1 8YU2 PRO A 149 ? UNP A0A0A8XFY0 LEU 143 'engineered mutation'   143 8  
1 8YU2 TYR A 252 ? UNP A0A0A8XFY0 PHE 246 'engineered mutation'   246 9  
1 8YU2 CYS A 332 ? UNP A0A0A8XFY0 LYS 326 'engineered mutation'   326 10 
1 8YU2 SER A 392 ? UNP A0A0A8XFY0 ASN 386 'engineered mutation'   386 11 
1 8YU2 LYS A 394 ? UNP A0A0A8XFY0 ILE 388 'engineered mutation'   388 12 
1 8YU2 ILE A 396 ? UNP A0A0A8XFY0 MET 390 'engineered mutation'   390 13 
1 8YU2 PHE A 432 ? UNP A0A0A8XFY0 LEU 426 'engineered mutation'   426 14 
1 8YU2 LEU A 438 ? UNP A0A0A8XFY0 PHE 432 'engineered mutation'   432 15 
1 8YU2 ALA A 439 ? UNP A0A0A8XFY0 THR 433 'engineered mutation'   433 16 
1 8YU2 SER A 441 ? UNP A0A0A8XFY0 LEU 435 'engineered mutation'   435 17 
1 8YU2 ILE A 444 ? UNP A0A0A8XFY0 SER 438 'engineered mutation'   438 18 
1 8YU2 LYS A 494 ? UNP A0A0A8XFY0 GLU 488 'engineered mutation'   488 19 
1 8YU2 CYS A 495 ? UNP A0A0A8XFY0 SER 489 'engineered mutation'   489 20 
1 8YU2 ARG A 496 ? UNP A0A0A8XFY0 TRP 490 'engineered mutation'   490 21 
1 8YU2 LEU A 511 ? UNP A0A0A8XFY0 PHE 505 'engineered mutation'   505 22 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2640  ? 
1 MORE         -12   ? 
1 'SSA (A^2)'  21550 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 21  ? ASP A 34  ? GLY A 15  ASP A 28  1 ? 14 
HELX_P HELX_P2  AA2 GLY A 50  ? ASN A 55  ? GLY A 44  ASN A 49  1 ? 6  
HELX_P HELX_P3  AA3 GLU A 65  ? TYR A 69  ? GLU A 59  TYR A 63  5 ? 5  
HELX_P HELX_P4  AA4 ASP A 74  ? MET A 81  ? ASP A 68  MET A 75  1 ? 8  
HELX_P HELX_P5  AA5 SER A 89  ? ASP A 105 ? SER A 83  ASP A 99  1 ? 17 
HELX_P HELX_P6  AA6 LEU A 106 ? LYS A 108 ? LEU A 100 LYS A 102 5 ? 3  
HELX_P HELX_P7  AA7 GLY A 160 ? PHE A 164 ? GLY A 154 PHE A 158 5 ? 5  
HELX_P HELX_P8  AA8 SER A 172 ? TRP A 174 ? SER A 166 TRP A 168 5 ? 3  
HELX_P HELX_P9  AA9 GLY A 191 ? ALA A 202 ? GLY A 185 ALA A 196 1 ? 12 
HELX_P HELX_P10 AB1 SER A 227 ? GLU A 236 ? SER A 221 GLU A 230 1 ? 10 
HELX_P HELX_P11 AB2 ASN A 237 ? SER A 248 ? ASN A 231 SER A 242 1 ? 12 
HELX_P HELX_P12 AB3 SER A 265 ? GLY A 280 ? SER A 259 GLY A 274 1 ? 16 
HELX_P HELX_P13 AB4 GLY A 281 ? GLU A 288 ? GLY A 275 GLU A 282 1 ? 8  
HELX_P HELX_P14 AB5 ASP A 296 ? VAL A 315 ? ASP A 290 VAL A 309 1 ? 20 
HELX_P HELX_P15 AB6 ASP A 317 ? THR A 325 ? ASP A 311 THR A 319 1 ? 9  
HELX_P HELX_P16 AB7 GLU A 342 ? ARG A 346 ? GLU A 336 ARG A 340 5 ? 5  
HELX_P HELX_P17 AB8 ALA A 388 ? ARG A 395 ? ALA A 382 ARG A 389 1 ? 8  
HELX_P HELX_P18 AB9 GLY A 400 ? ILE A 404 ? GLY A 394 ILE A 398 5 ? 5  
HELX_P HELX_P19 AC1 SER A 405 ? TRP A 410 ? SER A 399 TRP A 404 1 ? 6  
HELX_P HELX_P20 AC2 ASN A 440 ? HIS A 462 ? ASN A 434 HIS A 456 1 ? 23 
HELX_P HELX_P21 AC3 THR A 470 ? ASN A 486 ? THR A 464 ASN A 480 1 ? 17 
HELX_P HELX_P22 AC4 GLY A 515 ? ASN A 529 ? GLY A 509 ASN A 523 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 5 ? 
AA4 ? 2 ? 
AA5 ? 3 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? parallel      
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA4 1 2 ? parallel      
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 110 ? GLN A 111 ? ILE A 104 GLN A 105 
AA1 2 VAL A 39  ? PHE A 42  ? VAL A 33  PHE A 36  
AA1 3 PHE A 13  ? ILE A 18  ? PHE A 7   ILE A 12  
AA1 4 LYS A 137 ? THR A 145 ? LYS A 131 THR A 139 
AA1 5 PHE A 127 ? THR A 132 ? PHE A 121 THR A 126 
AA1 6 ILE A 116 ? ASP A 122 ? ILE A 110 ASP A 116 
AA1 7 ASP A 397 ? ARG A 399 ? ASP A 391 ARG A 393 
AA2 1 ILE A 110 ? GLN A 111 ? ILE A 104 GLN A 105 
AA2 2 VAL A 39  ? PHE A 42  ? VAL A 33  PHE A 36  
AA2 3 PHE A 13  ? ILE A 18  ? PHE A 7   ILE A 12  
AA2 4 LYS A 137 ? THR A 145 ? LYS A 131 THR A 139 
AA2 5 MET A 428 ? MET A 430 ? MET A 422 MET A 424 
AA3 1 GLU A 167 ? HIS A 170 ? GLU A 161 HIS A 164 
AA3 2 MET A 379 ? CYS A 382 ? MET A 373 CYS A 376 
AA3 3 ARG A 184 ? ILE A 188 ? ARG A 178 ILE A 182 
AA3 4 HIS A 207 ? GLN A 212 ? HIS A 201 GLN A 206 
AA3 5 VAL A 349 ? ASP A 353 ? VAL A 343 ASP A 347 
AA4 1 SER A 218 ? PRO A 220 ? SER A 212 PRO A 214 
AA4 2 LEU A 335 ? ASP A 337 ? LEU A 329 ASP A 331 
AA5 1 ILE A 359 ? LYS A 363 ? ILE A 353 LYS A 357 
AA5 2 CYS A 366 ? THR A 369 ? CYS A 360 THR A 363 
AA5 3 GLU A 374 ? LYS A 376 ? GLU A 368 LYS A 370 
AA6 1 ILE A 464 ? ALA A 469 ? ILE A 458 ALA A 463 
AA6 2 CYS A 534 ? GLN A 538 ? CYS A 528 GLN A 532 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLN A 111 ? O GLN A 105 N ALA A 41  ? N ALA A 35  
AA1 2 3 O ARG A 40  ? O ARG A 34  N ILE A 17  ? N ILE A 11  
AA1 3 4 N ASP A 14  ? N ASP A 8   O PHE A 142 ? O PHE A 136 
AA1 4 5 O ALA A 140 ? O ALA A 134 N TRP A 128 ? N TRP A 122 
AA1 5 6 O ASN A 129 ? O ASN A 123 N TYR A 120 ? N TYR A 114 
AA1 6 7 N ALA A 119 ? N ALA A 113 O ASP A 397 ? O ASP A 391 
AA2 1 2 O GLN A 111 ? O GLN A 105 N ALA A 41  ? N ALA A 35  
AA2 2 3 O ARG A 40  ? O ARG A 34  N ILE A 17  ? N ILE A 11  
AA2 3 4 N ASP A 14  ? N ASP A 8   O PHE A 142 ? O PHE A 136 
AA2 4 5 N THR A 145 ? N THR A 139 O PHE A 429 ? O PHE A 423 
AA3 1 2 N HIS A 169 ? N HIS A 163 O CYS A 382 ? O CYS A 376 
AA3 2 3 O ILE A 381 ? O ILE A 375 N GLY A 186 ? N GLY A 180 
AA3 3 4 N VAL A 187 ? N VAL A 181 O THR A 209 ? O THR A 203 
AA3 4 5 N VAL A 210 ? N VAL A 204 O GLU A 352 ? O GLU A 346 
AA4 1 2 N VAL A 219 ? N VAL A 213 O LEU A 335 ? O LEU A 329 
AA5 1 2 N GLU A 361 ? N GLU A 355 O VAL A 368 ? O VAL A 362 
AA5 2 3 N VAL A 367 ? N VAL A 361 O HIS A 375 ? O HIS A 369 
AA6 1 2 N GLU A 468 ? N GLU A 462 O LEU A 535 ? O LEU A 529 
# 
_pdbx_entry_details.entry_id                   8YU2 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLU A 118 ? ? -87.37  -72.20  
2  1 ALA A 145 ? ? -118.44 -134.83 
3  1 ASN A 231 ? ? -146.86 41.43   
4  1 GLU A 250 ? ? -54.36  108.00  
5  1 SER A 257 ? ? -88.24  40.15   
6  1 THR A 283 ? ? -67.72  -80.04  
7  1 VAL A 289 ? ? -130.76 -36.30  
8  1 CYS A 326 ? ? -83.43  -139.20 
9  1 SER A 332 ? ? -117.71 54.87   
10 1 ASP A 347 ? ? -65.50  99.44   
11 1 ALA A 377 ? ? -106.64 58.62   
12 1 ASP A 396 ? ? 59.86   9.25    
13 1 ASP A 406 ? ? -106.96 67.02   
14 1 LEU A 412 ? ? 57.92   16.11   
15 1 ASN A 418 ? ? 70.36   -4.28   
16 1 LYS A 486 ? ? -87.63  30.36   
17 1 ALA A 487 ? ? -137.04 -143.19 
18 1 ASN A 523 ? ? -81.19  38.08   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -5  ? A MET 1   
2  1 Y 1 A HIS -4  ? A HIS 2   
3  1 Y 1 A HIS -3  ? A HIS 3   
4  1 Y 1 A HIS -2  ? A HIS 4   
5  1 Y 1 A HIS -1  ? A HIS 5   
6  1 Y 1 A HIS 0   ? A HIS 6   
7  1 Y 1 A HIS 1   ? A HIS 7   
8  1 Y 1 A THR 2   ? A THR 8   
9  1 Y 1 A GLN 3   ? A GLN 9   
10 1 Y 1 A LYS 4   ? A LYS 10  
11 1 Y 1 A MET 5   ? A MET 11  
12 1 Y 1 A ARG 490 ? A ARG 496 
13 1 Y 1 A ILE 491 ? A ILE 497 
14 1 Y 1 A PHE 492 ? A PHE 498 
15 1 Y 1 A GLY 493 ? A GLY 499 
16 1 Y 1 A ALA 494 ? A ALA 500 
17 1 Y 1 A ASN 495 ? A ASN 501 
18 1 Y 1 A VAL 496 ? A VAL 502 
19 1 Y 1 A PRO 497 ? A PRO 503 
20 1 Y 1 A GLY 498 ? A GLY 504 
21 1 Y 1 A LYS 499 ? A LYS 505 
22 1 Y 1 A LYS 500 ? A LYS 506 
23 1 Y 1 A ASN 501 ? A ASN 507 
24 1 Y 1 A THR 502 ? A THR 508 
25 1 Y 1 A VAL 534 ? A VAL 540 
26 1 Y 1 A LYS 535 ? A LYS 541 
27 1 Y 1 A LYS 536 ? A LYS 542 
28 1 Y 1 A THR 537 ? A THR 543 
29 1 Y 1 A ASN 538 ? A ASN 544 
30 1 Y 1 A LEU 539 ? A LEU 545 
31 1 Y 1 A ILE 540 ? A ILE 546 
32 1 Y 1 A GLU 541 ? A GLU 547 
33 1 Y 1 A SER 542 ? A SER 548 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
CYS N      N N N 74  
CYS CA     C N R 75  
CYS C      C N N 76  
CYS O      O N N 77  
CYS CB     C N N 78  
CYS SG     S N N 79  
CYS OXT    O N N 80  
CYS H      H N N 81  
CYS H2     H N N 82  
CYS HA     H N N 83  
CYS HB2    H N N 84  
CYS HB3    H N N 85  
CYS HG     H N N 86  
CYS HXT    H N N 87  
FAD PA     P N R 88  
FAD O1A    O N N 89  
FAD O2A    O N N 90  
FAD O5B    O N N 91  
FAD C5B    C N N 92  
FAD C4B    C N R 93  
FAD O4B    O N N 94  
FAD C3B    C N S 95  
FAD O3B    O N N 96  
FAD C2B    C N R 97  
FAD O2B    O N N 98  
FAD C1B    C N R 99  
FAD N9A    N Y N 100 
FAD C8A    C Y N 101 
FAD N7A    N Y N 102 
FAD C5A    C Y N 103 
FAD C6A    C Y N 104 
FAD N6A    N N N 105 
FAD N1A    N Y N 106 
FAD C2A    C Y N 107 
FAD N3A    N Y N 108 
FAD C4A    C Y N 109 
FAD N1     N N N 110 
FAD C2     C N N 111 
FAD O2     O N N 112 
FAD N3     N N N 113 
FAD C4     C N N 114 
FAD O4     O N N 115 
FAD C4X    C N N 116 
FAD N5     N N N 117 
FAD C5X    C Y N 118 
FAD C6     C Y N 119 
FAD C7     C Y N 120 
FAD C7M    C N N 121 
FAD C8     C Y N 122 
FAD C8M    C N N 123 
FAD C9     C Y N 124 
FAD C9A    C Y N 125 
FAD N10    N N N 126 
FAD C10    C N N 127 
FAD "C1'"  C N N 128 
FAD "C2'"  C N S 129 
FAD "O2'"  O N N 130 
FAD "C3'"  C N S 131 
FAD "O3'"  O N N 132 
FAD "C4'"  C N R 133 
FAD "O4'"  O N N 134 
FAD "C5'"  C N N 135 
FAD "O5'"  O N N 136 
FAD P      P N R 137 
FAD O1P    O N N 138 
FAD O2P    O N N 139 
FAD O3P    O N N 140 
FAD HOA2   H N N 141 
FAD H51A   H N N 142 
FAD H52A   H N N 143 
FAD H4B    H N N 144 
FAD H3B    H N N 145 
FAD HO3A   H N N 146 
FAD H2B    H N N 147 
FAD HO2A   H N N 148 
FAD H1B    H N N 149 
FAD H8A    H N N 150 
FAD H61A   H N N 151 
FAD H62A   H N N 152 
FAD H2A    H N N 153 
FAD HN3    H N N 154 
FAD H6     H N N 155 
FAD HM71   H N N 156 
FAD HM72   H N N 157 
FAD HM73   H N N 158 
FAD HM81   H N N 159 
FAD HM82   H N N 160 
FAD HM83   H N N 161 
FAD H9     H N N 162 
FAD "H1'1" H N N 163 
FAD "H1'2" H N N 164 
FAD "H2'"  H N N 165 
FAD "HO2'" H N N 166 
FAD "H3'"  H N N 167 
FAD "HO3'" H N N 168 
FAD "H4'"  H N N 169 
FAD "HO4'" H N N 170 
FAD "H5'1" H N N 171 
FAD "H5'2" H N N 172 
FAD HOP2   H N N 173 
GLN N      N N N 174 
GLN CA     C N S 175 
GLN C      C N N 176 
GLN O      O N N 177 
GLN CB     C N N 178 
GLN CG     C N N 179 
GLN CD     C N N 180 
GLN OE1    O N N 181 
GLN NE2    N N N 182 
GLN OXT    O N N 183 
GLN H      H N N 184 
GLN H2     H N N 185 
GLN HA     H N N 186 
GLN HB2    H N N 187 
GLN HB3    H N N 188 
GLN HG2    H N N 189 
GLN HG3    H N N 190 
GLN HE21   H N N 191 
GLN HE22   H N N 192 
GLN HXT    H N N 193 
GLU N      N N N 194 
GLU CA     C N S 195 
GLU C      C N N 196 
GLU O      O N N 197 
GLU CB     C N N 198 
GLU CG     C N N 199 
GLU CD     C N N 200 
GLU OE1    O N N 201 
GLU OE2    O N N 202 
GLU OXT    O N N 203 
GLU H      H N N 204 
GLU H2     H N N 205 
GLU HA     H N N 206 
GLU HB2    H N N 207 
GLU HB3    H N N 208 
GLU HG2    H N N 209 
GLU HG3    H N N 210 
GLU HE2    H N N 211 
GLU HXT    H N N 212 
GLY N      N N N 213 
GLY CA     C N N 214 
GLY C      C N N 215 
GLY O      O N N 216 
GLY OXT    O N N 217 
GLY H      H N N 218 
GLY H2     H N N 219 
GLY HA2    H N N 220 
GLY HA3    H N N 221 
GLY HXT    H N N 222 
HIS N      N N N 223 
HIS CA     C N S 224 
HIS C      C N N 225 
HIS O      O N N 226 
HIS CB     C N N 227 
HIS CG     C Y N 228 
HIS ND1    N Y N 229 
HIS CD2    C Y N 230 
HIS CE1    C Y N 231 
HIS NE2    N Y N 232 
HIS OXT    O N N 233 
HIS H      H N N 234 
HIS H2     H N N 235 
HIS HA     H N N 236 
HIS HB2    H N N 237 
HIS HB3    H N N 238 
HIS HD1    H N N 239 
HIS HD2    H N N 240 
HIS HE1    H N N 241 
HIS HE2    H N N 242 
HIS HXT    H N N 243 
HOH O      O N N 244 
HOH H1     H N N 245 
HOH H2     H N N 246 
ILE N      N N N 247 
ILE CA     C N S 248 
ILE C      C N N 249 
ILE O      O N N 250 
ILE CB     C N S 251 
ILE CG1    C N N 252 
ILE CG2    C N N 253 
ILE CD1    C N N 254 
ILE OXT    O N N 255 
ILE H      H N N 256 
ILE H2     H N N 257 
ILE HA     H N N 258 
ILE HB     H N N 259 
ILE HG12   H N N 260 
ILE HG13   H N N 261 
ILE HG21   H N N 262 
ILE HG22   H N N 263 
ILE HG23   H N N 264 
ILE HD11   H N N 265 
ILE HD12   H N N 266 
ILE HD13   H N N 267 
ILE HXT    H N N 268 
LEU N      N N N 269 
LEU CA     C N S 270 
LEU C      C N N 271 
LEU O      O N N 272 
LEU CB     C N N 273 
LEU CG     C N N 274 
LEU CD1    C N N 275 
LEU CD2    C N N 276 
LEU OXT    O N N 277 
LEU H      H N N 278 
LEU H2     H N N 279 
LEU HA     H N N 280 
LEU HB2    H N N 281 
LEU HB3    H N N 282 
LEU HG     H N N 283 
LEU HD11   H N N 284 
LEU HD12   H N N 285 
LEU HD13   H N N 286 
LEU HD21   H N N 287 
LEU HD22   H N N 288 
LEU HD23   H N N 289 
LEU HXT    H N N 290 
LYS N      N N N 291 
LYS CA     C N S 292 
LYS C      C N N 293 
LYS O      O N N 294 
LYS CB     C N N 295 
LYS CG     C N N 296 
LYS CD     C N N 297 
LYS CE     C N N 298 
LYS NZ     N N N 299 
LYS OXT    O N N 300 
LYS H      H N N 301 
LYS H2     H N N 302 
LYS HA     H N N 303 
LYS HB2    H N N 304 
LYS HB3    H N N 305 
LYS HG2    H N N 306 
LYS HG3    H N N 307 
LYS HD2    H N N 308 
LYS HD3    H N N 309 
LYS HE2    H N N 310 
LYS HE3    H N N 311 
LYS HZ1    H N N 312 
LYS HZ2    H N N 313 
LYS HZ3    H N N 314 
LYS HXT    H N N 315 
MET N      N N N 316 
MET CA     C N S 317 
MET C      C N N 318 
MET O      O N N 319 
MET CB     C N N 320 
MET CG     C N N 321 
MET SD     S N N 322 
MET CE     C N N 323 
MET OXT    O N N 324 
MET H      H N N 325 
MET H2     H N N 326 
MET HA     H N N 327 
MET HB2    H N N 328 
MET HB3    H N N 329 
MET HG2    H N N 330 
MET HG3    H N N 331 
MET HE1    H N N 332 
MET HE2    H N N 333 
MET HE3    H N N 334 
MET HXT    H N N 335 
NAD PA     P N S 336 
NAD O1A    O N N 337 
NAD O2A    O N N 338 
NAD O5B    O N N 339 
NAD C5B    C N N 340 
NAD C4B    C N R 341 
NAD O4B    O N N 342 
NAD C3B    C N S 343 
NAD O3B    O N N 344 
NAD C2B    C N R 345 
NAD O2B    O N N 346 
NAD C1B    C N R 347 
NAD N9A    N Y N 348 
NAD C8A    C Y N 349 
NAD N7A    N Y N 350 
NAD C5A    C Y N 351 
NAD C6A    C Y N 352 
NAD N6A    N N N 353 
NAD N1A    N Y N 354 
NAD C2A    C Y N 355 
NAD N3A    N Y N 356 
NAD C4A    C Y N 357 
NAD O3     O N N 358 
NAD PN     P N N 359 
NAD O1N    O N N 360 
NAD O2N    O N N 361 
NAD O5D    O N N 362 
NAD C5D    C N N 363 
NAD C4D    C N R 364 
NAD O4D    O N N 365 
NAD C3D    C N S 366 
NAD O3D    O N N 367 
NAD C2D    C N R 368 
NAD O2D    O N N 369 
NAD C1D    C N R 370 
NAD N1N    N Y N 371 
NAD C2N    C Y N 372 
NAD C3N    C Y N 373 
NAD C7N    C N N 374 
NAD O7N    O N N 375 
NAD N7N    N N N 376 
NAD C4N    C Y N 377 
NAD C5N    C Y N 378 
NAD C6N    C Y N 379 
NAD HOA2   H N N 380 
NAD H51A   H N N 381 
NAD H52A   H N N 382 
NAD H4B    H N N 383 
NAD H3B    H N N 384 
NAD HO3A   H N N 385 
NAD H2B    H N N 386 
NAD HO2A   H N N 387 
NAD H1B    H N N 388 
NAD H8A    H N N 389 
NAD H61A   H N N 390 
NAD H62A   H N N 391 
NAD H2A    H N N 392 
NAD H51N   H N N 393 
NAD H52N   H N N 394 
NAD H4D    H N N 395 
NAD H3D    H N N 396 
NAD HO3N   H N N 397 
NAD H2D    H N N 398 
NAD HO2N   H N N 399 
NAD H1D    H N N 400 
NAD H2N    H N N 401 
NAD H71N   H N N 402 
NAD H72N   H N N 403 
NAD H4N    H N N 404 
NAD H5N    H N N 405 
NAD H6N    H N N 406 
PHE N      N N N 407 
PHE CA     C N S 408 
PHE C      C N N 409 
PHE O      O N N 410 
PHE CB     C N N 411 
PHE CG     C Y N 412 
PHE CD1    C Y N 413 
PHE CD2    C Y N 414 
PHE CE1    C Y N 415 
PHE CE2    C Y N 416 
PHE CZ     C Y N 417 
PHE OXT    O N N 418 
PHE H      H N N 419 
PHE H2     H N N 420 
PHE HA     H N N 421 
PHE HB2    H N N 422 
PHE HB3    H N N 423 
PHE HD1    H N N 424 
PHE HD2    H N N 425 
PHE HE1    H N N 426 
PHE HE2    H N N 427 
PHE HZ     H N N 428 
PHE HXT    H N N 429 
PRO N      N N N 430 
PRO CA     C N S 431 
PRO C      C N N 432 
PRO O      O N N 433 
PRO CB     C N N 434 
PRO CG     C N N 435 
PRO CD     C N N 436 
PRO OXT    O N N 437 
PRO H      H N N 438 
PRO HA     H N N 439 
PRO HB2    H N N 440 
PRO HB3    H N N 441 
PRO HG2    H N N 442 
PRO HG3    H N N 443 
PRO HD2    H N N 444 
PRO HD3    H N N 445 
PRO HXT    H N N 446 
SER N      N N N 447 
SER CA     C N S 448 
SER C      C N N 449 
SER O      O N N 450 
SER CB     C N N 451 
SER OG     O N N 452 
SER OXT    O N N 453 
SER H      H N N 454 
SER H2     H N N 455 
SER HA     H N N 456 
SER HB2    H N N 457 
SER HB3    H N N 458 
SER HG     H N N 459 
SER HXT    H N N 460 
THR N      N N N 461 
THR CA     C N S 462 
THR C      C N N 463 
THR O      O N N 464 
THR CB     C N R 465 
THR OG1    O N N 466 
THR CG2    C N N 467 
THR OXT    O N N 468 
THR H      H N N 469 
THR H2     H N N 470 
THR HA     H N N 471 
THR HB     H N N 472 
THR HG1    H N N 473 
THR HG21   H N N 474 
THR HG22   H N N 475 
THR HG23   H N N 476 
THR HXT    H N N 477 
TRP N      N N N 478 
TRP CA     C N S 479 
TRP C      C N N 480 
TRP O      O N N 481 
TRP CB     C N N 482 
TRP CG     C Y N 483 
TRP CD1    C Y N 484 
TRP CD2    C Y N 485 
TRP NE1    N Y N 486 
TRP CE2    C Y N 487 
TRP CE3    C Y N 488 
TRP CZ2    C Y N 489 
TRP CZ3    C Y N 490 
TRP CH2    C Y N 491 
TRP OXT    O N N 492 
TRP H      H N N 493 
TRP H2     H N N 494 
TRP HA     H N N 495 
TRP HB2    H N N 496 
TRP HB3    H N N 497 
TRP HD1    H N N 498 
TRP HE1    H N N 499 
TRP HE3    H N N 500 
TRP HZ2    H N N 501 
TRP HZ3    H N N 502 
TRP HH2    H N N 503 
TRP HXT    H N N 504 
TYR N      N N N 505 
TYR CA     C N S 506 
TYR C      C N N 507 
TYR O      O N N 508 
TYR CB     C N N 509 
TYR CG     C Y N 510 
TYR CD1    C Y N 511 
TYR CD2    C Y N 512 
TYR CE1    C Y N 513 
TYR CE2    C Y N 514 
TYR CZ     C Y N 515 
TYR OH     O N N 516 
TYR OXT    O N N 517 
TYR H      H N N 518 
TYR H2     H N N 519 
TYR HA     H N N 520 
TYR HB2    H N N 521 
TYR HB3    H N N 522 
TYR HD1    H N N 523 
TYR HD2    H N N 524 
TYR HE1    H N N 525 
TYR HE2    H N N 526 
TYR HH     H N N 527 
TYR HXT    H N N 528 
VAL N      N N N 529 
VAL CA     C N S 530 
VAL C      C N N 531 
VAL O      O N N 532 
VAL CB     C N N 533 
VAL CG1    C N N 534 
VAL CG2    C N N 535 
VAL OXT    O N N 536 
VAL H      H N N 537 
VAL H2     H N N 538 
VAL HA     H N N 539 
VAL HB     H N N 540 
VAL HG11   H N N 541 
VAL HG12   H N N 542 
VAL HG13   H N N 543 
VAL HG21   H N N 544 
VAL HG22   H N N 545 
VAL HG23   H N N 546 
VAL HXT    H N N 547 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
FAD PA    O1A    doub N N 83  
FAD PA    O2A    sing N N 84  
FAD PA    O5B    sing N N 85  
FAD PA    O3P    sing N N 86  
FAD O2A   HOA2   sing N N 87  
FAD O5B   C5B    sing N N 88  
FAD C5B   C4B    sing N N 89  
FAD C5B   H51A   sing N N 90  
FAD C5B   H52A   sing N N 91  
FAD C4B   O4B    sing N N 92  
FAD C4B   C3B    sing N N 93  
FAD C4B   H4B    sing N N 94  
FAD O4B   C1B    sing N N 95  
FAD C3B   O3B    sing N N 96  
FAD C3B   C2B    sing N N 97  
FAD C3B   H3B    sing N N 98  
FAD O3B   HO3A   sing N N 99  
FAD C2B   O2B    sing N N 100 
FAD C2B   C1B    sing N N 101 
FAD C2B   H2B    sing N N 102 
FAD O2B   HO2A   sing N N 103 
FAD C1B   N9A    sing N N 104 
FAD C1B   H1B    sing N N 105 
FAD N9A   C8A    sing Y N 106 
FAD N9A   C4A    sing Y N 107 
FAD C8A   N7A    doub Y N 108 
FAD C8A   H8A    sing N N 109 
FAD N7A   C5A    sing Y N 110 
FAD C5A   C6A    sing Y N 111 
FAD C5A   C4A    doub Y N 112 
FAD C6A   N6A    sing N N 113 
FAD C6A   N1A    doub Y N 114 
FAD N6A   H61A   sing N N 115 
FAD N6A   H62A   sing N N 116 
FAD N1A   C2A    sing Y N 117 
FAD C2A   N3A    doub Y N 118 
FAD C2A   H2A    sing N N 119 
FAD N3A   C4A    sing Y N 120 
FAD N1    C2     sing N N 121 
FAD N1    C10    doub N N 122 
FAD C2    O2     doub N N 123 
FAD C2    N3     sing N N 124 
FAD N3    C4     sing N N 125 
FAD N3    HN3    sing N N 126 
FAD C4    O4     doub N N 127 
FAD C4    C4X    sing N N 128 
FAD C4X   N5     doub N N 129 
FAD C4X   C10    sing N N 130 
FAD N5    C5X    sing N N 131 
FAD C5X   C6     doub Y N 132 
FAD C5X   C9A    sing Y N 133 
FAD C6    C7     sing Y N 134 
FAD C6    H6     sing N N 135 
FAD C7    C7M    sing N N 136 
FAD C7    C8     doub Y N 137 
FAD C7M   HM71   sing N N 138 
FAD C7M   HM72   sing N N 139 
FAD C7M   HM73   sing N N 140 
FAD C8    C8M    sing N N 141 
FAD C8    C9     sing Y N 142 
FAD C8M   HM81   sing N N 143 
FAD C8M   HM82   sing N N 144 
FAD C8M   HM83   sing N N 145 
FAD C9    C9A    doub Y N 146 
FAD C9    H9     sing N N 147 
FAD C9A   N10    sing N N 148 
FAD N10   C10    sing N N 149 
FAD N10   "C1'"  sing N N 150 
FAD "C1'" "C2'"  sing N N 151 
FAD "C1'" "H1'1" sing N N 152 
FAD "C1'" "H1'2" sing N N 153 
FAD "C2'" "O2'"  sing N N 154 
FAD "C2'" "C3'"  sing N N 155 
FAD "C2'" "H2'"  sing N N 156 
FAD "O2'" "HO2'" sing N N 157 
FAD "C3'" "O3'"  sing N N 158 
FAD "C3'" "C4'"  sing N N 159 
FAD "C3'" "H3'"  sing N N 160 
FAD "O3'" "HO3'" sing N N 161 
FAD "C4'" "O4'"  sing N N 162 
FAD "C4'" "C5'"  sing N N 163 
FAD "C4'" "H4'"  sing N N 164 
FAD "O4'" "HO4'" sing N N 165 
FAD "C5'" "O5'"  sing N N 166 
FAD "C5'" "H5'1" sing N N 167 
FAD "C5'" "H5'2" sing N N 168 
FAD "O5'" P      sing N N 169 
FAD P     O1P    doub N N 170 
FAD P     O2P    sing N N 171 
FAD P     O3P    sing N N 172 
FAD O2P   HOP2   sing N N 173 
GLN N     CA     sing N N 174 
GLN N     H      sing N N 175 
GLN N     H2     sing N N 176 
GLN CA    C      sing N N 177 
GLN CA    CB     sing N N 178 
GLN CA    HA     sing N N 179 
GLN C     O      doub N N 180 
GLN C     OXT    sing N N 181 
GLN CB    CG     sing N N 182 
GLN CB    HB2    sing N N 183 
GLN CB    HB3    sing N N 184 
GLN CG    CD     sing N N 185 
GLN CG    HG2    sing N N 186 
GLN CG    HG3    sing N N 187 
GLN CD    OE1    doub N N 188 
GLN CD    NE2    sing N N 189 
GLN NE2   HE21   sing N N 190 
GLN NE2   HE22   sing N N 191 
GLN OXT   HXT    sing N N 192 
GLU N     CA     sing N N 193 
GLU N     H      sing N N 194 
GLU N     H2     sing N N 195 
GLU CA    C      sing N N 196 
GLU CA    CB     sing N N 197 
GLU CA    HA     sing N N 198 
GLU C     O      doub N N 199 
GLU C     OXT    sing N N 200 
GLU CB    CG     sing N N 201 
GLU CB    HB2    sing N N 202 
GLU CB    HB3    sing N N 203 
GLU CG    CD     sing N N 204 
GLU CG    HG2    sing N N 205 
GLU CG    HG3    sing N N 206 
GLU CD    OE1    doub N N 207 
GLU CD    OE2    sing N N 208 
GLU OE2   HE2    sing N N 209 
GLU OXT   HXT    sing N N 210 
GLY N     CA     sing N N 211 
GLY N     H      sing N N 212 
GLY N     H2     sing N N 213 
GLY CA    C      sing N N 214 
GLY CA    HA2    sing N N 215 
GLY CA    HA3    sing N N 216 
GLY C     O      doub N N 217 
GLY C     OXT    sing N N 218 
GLY OXT   HXT    sing N N 219 
HIS N     CA     sing N N 220 
HIS N     H      sing N N 221 
HIS N     H2     sing N N 222 
HIS CA    C      sing N N 223 
HIS CA    CB     sing N N 224 
HIS CA    HA     sing N N 225 
HIS C     O      doub N N 226 
HIS C     OXT    sing N N 227 
HIS CB    CG     sing N N 228 
HIS CB    HB2    sing N N 229 
HIS CB    HB3    sing N N 230 
HIS CG    ND1    sing Y N 231 
HIS CG    CD2    doub Y N 232 
HIS ND1   CE1    doub Y N 233 
HIS ND1   HD1    sing N N 234 
HIS CD2   NE2    sing Y N 235 
HIS CD2   HD2    sing N N 236 
HIS CE1   NE2    sing Y N 237 
HIS CE1   HE1    sing N N 238 
HIS NE2   HE2    sing N N 239 
HIS OXT   HXT    sing N N 240 
HOH O     H1     sing N N 241 
HOH O     H2     sing N N 242 
ILE N     CA     sing N N 243 
ILE N     H      sing N N 244 
ILE N     H2     sing N N 245 
ILE CA    C      sing N N 246 
ILE CA    CB     sing N N 247 
ILE CA    HA     sing N N 248 
ILE C     O      doub N N 249 
ILE C     OXT    sing N N 250 
ILE CB    CG1    sing N N 251 
ILE CB    CG2    sing N N 252 
ILE CB    HB     sing N N 253 
ILE CG1   CD1    sing N N 254 
ILE CG1   HG12   sing N N 255 
ILE CG1   HG13   sing N N 256 
ILE CG2   HG21   sing N N 257 
ILE CG2   HG22   sing N N 258 
ILE CG2   HG23   sing N N 259 
ILE CD1   HD11   sing N N 260 
ILE CD1   HD12   sing N N 261 
ILE CD1   HD13   sing N N 262 
ILE OXT   HXT    sing N N 263 
LEU N     CA     sing N N 264 
LEU N     H      sing N N 265 
LEU N     H2     sing N N 266 
LEU CA    C      sing N N 267 
LEU CA    CB     sing N N 268 
LEU CA    HA     sing N N 269 
LEU C     O      doub N N 270 
LEU C     OXT    sing N N 271 
LEU CB    CG     sing N N 272 
LEU CB    HB2    sing N N 273 
LEU CB    HB3    sing N N 274 
LEU CG    CD1    sing N N 275 
LEU CG    CD2    sing N N 276 
LEU CG    HG     sing N N 277 
LEU CD1   HD11   sing N N 278 
LEU CD1   HD12   sing N N 279 
LEU CD1   HD13   sing N N 280 
LEU CD2   HD21   sing N N 281 
LEU CD2   HD22   sing N N 282 
LEU CD2   HD23   sing N N 283 
LEU OXT   HXT    sing N N 284 
LYS N     CA     sing N N 285 
LYS N     H      sing N N 286 
LYS N     H2     sing N N 287 
LYS CA    C      sing N N 288 
LYS CA    CB     sing N N 289 
LYS CA    HA     sing N N 290 
LYS C     O      doub N N 291 
LYS C     OXT    sing N N 292 
LYS CB    CG     sing N N 293 
LYS CB    HB2    sing N N 294 
LYS CB    HB3    sing N N 295 
LYS CG    CD     sing N N 296 
LYS CG    HG2    sing N N 297 
LYS CG    HG3    sing N N 298 
LYS CD    CE     sing N N 299 
LYS CD    HD2    sing N N 300 
LYS CD    HD3    sing N N 301 
LYS CE    NZ     sing N N 302 
LYS CE    HE2    sing N N 303 
LYS CE    HE3    sing N N 304 
LYS NZ    HZ1    sing N N 305 
LYS NZ    HZ2    sing N N 306 
LYS NZ    HZ3    sing N N 307 
LYS OXT   HXT    sing N N 308 
MET N     CA     sing N N 309 
MET N     H      sing N N 310 
MET N     H2     sing N N 311 
MET CA    C      sing N N 312 
MET CA    CB     sing N N 313 
MET CA    HA     sing N N 314 
MET C     O      doub N N 315 
MET C     OXT    sing N N 316 
MET CB    CG     sing N N 317 
MET CB    HB2    sing N N 318 
MET CB    HB3    sing N N 319 
MET CG    SD     sing N N 320 
MET CG    HG2    sing N N 321 
MET CG    HG3    sing N N 322 
MET SD    CE     sing N N 323 
MET CE    HE1    sing N N 324 
MET CE    HE2    sing N N 325 
MET CE    HE3    sing N N 326 
MET OXT   HXT    sing N N 327 
NAD PA    O1A    doub N N 328 
NAD PA    O2A    sing N N 329 
NAD PA    O5B    sing N N 330 
NAD PA    O3     sing N N 331 
NAD O2A   HOA2   sing N N 332 
NAD O5B   C5B    sing N N 333 
NAD C5B   C4B    sing N N 334 
NAD C5B   H51A   sing N N 335 
NAD C5B   H52A   sing N N 336 
NAD C4B   O4B    sing N N 337 
NAD C4B   C3B    sing N N 338 
NAD C4B   H4B    sing N N 339 
NAD O4B   C1B    sing N N 340 
NAD C3B   O3B    sing N N 341 
NAD C3B   C2B    sing N N 342 
NAD C3B   H3B    sing N N 343 
NAD O3B   HO3A   sing N N 344 
NAD C2B   O2B    sing N N 345 
NAD C2B   C1B    sing N N 346 
NAD C2B   H2B    sing N N 347 
NAD O2B   HO2A   sing N N 348 
NAD C1B   N9A    sing N N 349 
NAD C1B   H1B    sing N N 350 
NAD N9A   C8A    sing Y N 351 
NAD N9A   C4A    sing Y N 352 
NAD C8A   N7A    doub Y N 353 
NAD C8A   H8A    sing N N 354 
NAD N7A   C5A    sing Y N 355 
NAD C5A   C6A    sing Y N 356 
NAD C5A   C4A    doub Y N 357 
NAD C6A   N6A    sing N N 358 
NAD C6A   N1A    doub Y N 359 
NAD N6A   H61A   sing N N 360 
NAD N6A   H62A   sing N N 361 
NAD N1A   C2A    sing Y N 362 
NAD C2A   N3A    doub Y N 363 
NAD C2A   H2A    sing N N 364 
NAD N3A   C4A    sing Y N 365 
NAD O3    PN     sing N N 366 
NAD PN    O1N    doub N N 367 
NAD PN    O2N    sing N N 368 
NAD PN    O5D    sing N N 369 
NAD O5D   C5D    sing N N 370 
NAD C5D   C4D    sing N N 371 
NAD C5D   H51N   sing N N 372 
NAD C5D   H52N   sing N N 373 
NAD C4D   O4D    sing N N 374 
NAD C4D   C3D    sing N N 375 
NAD C4D   H4D    sing N N 376 
NAD O4D   C1D    sing N N 377 
NAD C3D   O3D    sing N N 378 
NAD C3D   C2D    sing N N 379 
NAD C3D   H3D    sing N N 380 
NAD O3D   HO3N   sing N N 381 
NAD C2D   O2D    sing N N 382 
NAD C2D   C1D    sing N N 383 
NAD C2D   H2D    sing N N 384 
NAD O2D   HO2N   sing N N 385 
NAD C1D   N1N    sing N N 386 
NAD C1D   H1D    sing N N 387 
NAD N1N   C2N    sing Y N 388 
NAD N1N   C6N    doub Y N 389 
NAD C2N   C3N    doub Y N 390 
NAD C2N   H2N    sing N N 391 
NAD C3N   C7N    sing N N 392 
NAD C3N   C4N    sing Y N 393 
NAD C7N   O7N    doub N N 394 
NAD C7N   N7N    sing N N 395 
NAD N7N   H71N   sing N N 396 
NAD N7N   H72N   sing N N 397 
NAD C4N   C5N    doub Y N 398 
NAD C4N   H4N    sing N N 399 
NAD C5N   C6N    sing Y N 400 
NAD C5N   H5N    sing N N 401 
NAD C6N   H6N    sing N N 402 
PHE N     CA     sing N N 403 
PHE N     H      sing N N 404 
PHE N     H2     sing N N 405 
PHE CA    C      sing N N 406 
PHE CA    CB     sing N N 407 
PHE CA    HA     sing N N 408 
PHE C     O      doub N N 409 
PHE C     OXT    sing N N 410 
PHE CB    CG     sing N N 411 
PHE CB    HB2    sing N N 412 
PHE CB    HB3    sing N N 413 
PHE CG    CD1    doub Y N 414 
PHE CG    CD2    sing Y N 415 
PHE CD1   CE1    sing Y N 416 
PHE CD1   HD1    sing N N 417 
PHE CD2   CE2    doub Y N 418 
PHE CD2   HD2    sing N N 419 
PHE CE1   CZ     doub Y N 420 
PHE CE1   HE1    sing N N 421 
PHE CE2   CZ     sing Y N 422 
PHE CE2   HE2    sing N N 423 
PHE CZ    HZ     sing N N 424 
PHE OXT   HXT    sing N N 425 
PRO N     CA     sing N N 426 
PRO N     CD     sing N N 427 
PRO N     H      sing N N 428 
PRO CA    C      sing N N 429 
PRO CA    CB     sing N N 430 
PRO CA    HA     sing N N 431 
PRO C     O      doub N N 432 
PRO C     OXT    sing N N 433 
PRO CB    CG     sing N N 434 
PRO CB    HB2    sing N N 435 
PRO CB    HB3    sing N N 436 
PRO CG    CD     sing N N 437 
PRO CG    HG2    sing N N 438 
PRO CG    HG3    sing N N 439 
PRO CD    HD2    sing N N 440 
PRO CD    HD3    sing N N 441 
PRO OXT   HXT    sing N N 442 
SER N     CA     sing N N 443 
SER N     H      sing N N 444 
SER N     H2     sing N N 445 
SER CA    C      sing N N 446 
SER CA    CB     sing N N 447 
SER CA    HA     sing N N 448 
SER C     O      doub N N 449 
SER C     OXT    sing N N 450 
SER CB    OG     sing N N 451 
SER CB    HB2    sing N N 452 
SER CB    HB3    sing N N 453 
SER OG    HG     sing N N 454 
SER OXT   HXT    sing N N 455 
THR N     CA     sing N N 456 
THR N     H      sing N N 457 
THR N     H2     sing N N 458 
THR CA    C      sing N N 459 
THR CA    CB     sing N N 460 
THR CA    HA     sing N N 461 
THR C     O      doub N N 462 
THR C     OXT    sing N N 463 
THR CB    OG1    sing N N 464 
THR CB    CG2    sing N N 465 
THR CB    HB     sing N N 466 
THR OG1   HG1    sing N N 467 
THR CG2   HG21   sing N N 468 
THR CG2   HG22   sing N N 469 
THR CG2   HG23   sing N N 470 
THR OXT   HXT    sing N N 471 
TRP N     CA     sing N N 472 
TRP N     H      sing N N 473 
TRP N     H2     sing N N 474 
TRP CA    C      sing N N 475 
TRP CA    CB     sing N N 476 
TRP CA    HA     sing N N 477 
TRP C     O      doub N N 478 
TRP C     OXT    sing N N 479 
TRP CB    CG     sing N N 480 
TRP CB    HB2    sing N N 481 
TRP CB    HB3    sing N N 482 
TRP CG    CD1    doub Y N 483 
TRP CG    CD2    sing Y N 484 
TRP CD1   NE1    sing Y N 485 
TRP CD1   HD1    sing N N 486 
TRP CD2   CE2    doub Y N 487 
TRP CD2   CE3    sing Y N 488 
TRP NE1   CE2    sing Y N 489 
TRP NE1   HE1    sing N N 490 
TRP CE2   CZ2    sing Y N 491 
TRP CE3   CZ3    doub Y N 492 
TRP CE3   HE3    sing N N 493 
TRP CZ2   CH2    doub Y N 494 
TRP CZ2   HZ2    sing N N 495 
TRP CZ3   CH2    sing Y N 496 
TRP CZ3   HZ3    sing N N 497 
TRP CH2   HH2    sing N N 498 
TRP OXT   HXT    sing N N 499 
TYR N     CA     sing N N 500 
TYR N     H      sing N N 501 
TYR N     H2     sing N N 502 
TYR CA    C      sing N N 503 
TYR CA    CB     sing N N 504 
TYR CA    HA     sing N N 505 
TYR C     O      doub N N 506 
TYR C     OXT    sing N N 507 
TYR CB    CG     sing N N 508 
TYR CB    HB2    sing N N 509 
TYR CB    HB3    sing N N 510 
TYR CG    CD1    doub Y N 511 
TYR CG    CD2    sing Y N 512 
TYR CD1   CE1    sing Y N 513 
TYR CD1   HD1    sing N N 514 
TYR CD2   CE2    doub Y N 515 
TYR CD2   HD2    sing N N 516 
TYR CE1   CZ     doub Y N 517 
TYR CE1   HE1    sing N N 518 
TYR CE2   CZ     sing Y N 519 
TYR CE2   HE2    sing N N 520 
TYR CZ    OH     sing N N 521 
TYR OH    HH     sing N N 522 
TYR OXT   HXT    sing N N 523 
VAL N     CA     sing N N 524 
VAL N     H      sing N N 525 
VAL N     H2     sing N N 526 
VAL CA    C      sing N N 527 
VAL CA    CB     sing N N 528 
VAL CA    HA     sing N N 529 
VAL C     O      doub N N 530 
VAL C     OXT    sing N N 531 
VAL CB    CG1    sing N N 532 
VAL CB    CG2    sing N N 533 
VAL CB    HB     sing N N 534 
VAL CG1   HG11   sing N N 535 
VAL CG1   HG12   sing N N 536 
VAL CG1   HG13   sing N N 537 
VAL CG2   HG21   sing N N 538 
VAL CG2   HG22   sing N N 539 
VAL CG2   HG23   sing N N 540 
VAL OXT   HXT    sing N N 541 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           21922804 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6A37 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YU2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018979 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002235 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018723 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009811 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P 15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2678   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0495   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N     . ASP A 1 12  ? 17.88872  -18.72946 38.62026  1.000 96.15778  ? 6   ASP A N     1 ? 
ATOM   2    C CA    . ASP A 1 12  ? 17.34725  -17.72474 39.52806  1.000 88.90122  ? 6   ASP A CA    1 ? 
ATOM   3    C C     . ASP A 1 12  ? 17.65813  -16.31077 39.05119  1.000 86.59659  ? 6   ASP A C     1 ? 
ATOM   4    O O     . ASP A 1 12  ? 18.71617  -16.05363 38.47668  1.000 85.68630  ? 6   ASP A O     1 ? 
ATOM   5    C CB    . ASP A 1 12  ? 17.89544  -17.92536 40.94360  1.000 86.38972  ? 6   ASP A CB    1 ? 
ATOM   6    C CG    . ASP A 1 12  ? 16.85642  -18.47823 41.90073  1.000 90.42882  ? 6   ASP A CG    1 ? 
ATOM   7    O OD1   . ASP A 1 12  ? 15.80743  -17.82509 42.08382  1.000 83.04892  ? 6   ASP A OD1   1 ? 
ATOM   8    O OD2   . ASP A 1 12  ? 17.08950  -19.56343 42.47356  1.000 99.82914  ? 6   ASP A OD2   1 ? 
ATOM   9    N N     . PHE A 1 13  ? 16.72030  -15.39839 39.29336  1.000 84.67807  ? 7   PHE A N     1 ? 
ATOM   10   C CA    . PHE A 1 13  ? 16.90538  -13.98666 38.99817  1.000 83.61565  ? 7   PHE A CA    1 ? 
ATOM   11   C C     . PHE A 1 13  ? 16.30834  -13.16632 40.13054  1.000 84.82165  ? 7   PHE A C     1 ? 
ATOM   12   O O     . PHE A 1 13  ? 15.48879  -13.65358 40.91209  1.000 83.90422  ? 7   PHE A O     1 ? 
ATOM   13   C CB    . PHE A 1 13  ? 16.25090  -13.58292 37.66894  1.000 81.60898  ? 7   PHE A CB    1 ? 
ATOM   14   C CG    . PHE A 1 13  ? 16.82169  -14.28191 36.47094  1.000 76.12343  ? 7   PHE A CG    1 ? 
ATOM   15   C CD1   . PHE A 1 13  ? 18.10404  -13.99940 36.03144  1.000 78.83243  ? 7   PHE A CD1   1 ? 
ATOM   16   C CD2   . PHE A 1 13  ? 16.07085  -15.21462 35.77683  1.000 78.43757  ? 7   PHE A CD2   1 ? 
ATOM   17   C CE1   . PHE A 1 13  ? 18.62904  -14.64032 34.92581  1.000 71.24758  ? 7   PHE A CE1   1 ? 
ATOM   18   C CE2   . PHE A 1 13  ? 16.59005  -15.85686 34.67191  1.000 79.79294  ? 7   PHE A CE2   1 ? 
ATOM   19   C CZ    . PHE A 1 13  ? 17.87092  -15.57086 34.24664  1.000 66.62182  ? 7   PHE A CZ    1 ? 
ATOM   20   N N     . ASP A 1 14  ? 16.73796  -11.90794 40.22081  1.000 84.05521  ? 8   ASP A N     1 ? 
ATOM   21   C CA    . ASP A 1 14  ? 16.05229  -10.97575 41.10568  1.000 82.68219  ? 8   ASP A CA    1 ? 
ATOM   22   C C     . ASP A 1 14  ? 14.77027  -10.45832 40.47288  1.000 81.65982  ? 8   ASP A C     1 ? 
ATOM   23   O O     . ASP A 1 14  ? 13.79031  -10.20137 41.18116  1.000 75.72106  ? 8   ASP A O     1 ? 
ATOM   24   C CB    . ASP A 1 14  ? 16.96544  -9.80215  41.46836  1.000 84.15866  ? 8   ASP A CB    1 ? 
ATOM   25   C CG    . ASP A 1 14  ? 18.31742  -10.24970 41.98018  1.000 82.80579  ? 8   ASP A CG    1 ? 
ATOM   26   O OD1   . ASP A 1 14  ? 18.35774  -11.08013 42.91181  1.000 77.37049  ? 8   ASP A OD1   1 ? 
ATOM   27   O OD2   . ASP A 1 14  ? 19.34084  -9.75881  41.46322  1.000 82.39531  ? 8   ASP A OD2   1 ? 
ATOM   28   N N     . ALA A 1 15  ? 14.75617  -10.31710 39.15015  1.000 82.60590  ? 9   ALA A N     1 ? 
ATOM   29   C CA    . ALA A 1 15  ? 13.59609  -9.80840  38.43890  1.000 77.62873  ? 9   ALA A CA    1 ? 
ATOM   30   C C     . ALA A 1 15  ? 13.58065  -10.38491 37.03131  1.000 77.98604  ? 9   ALA A C     1 ? 
ATOM   31   O O     . ALA A 1 15  ? 14.63141  -10.52333 36.39957  1.000 76.26893  ? 9   ALA A O     1 ? 
ATOM   32   C CB    . ALA A 1 15  ? 13.60689  -8.27722  38.38959  1.000 75.18723  ? 9   ALA A CB    1 ? 
ATOM   33   N N     . ILE A 1 16  ? 12.38803  -10.73074 36.55301  1.000 70.56011  ? 10  ILE A N     1 ? 
ATOM   34   C CA    . ILE A 1 16  ? 12.17860  -11.15804 35.17398  1.000 69.48604  ? 10  ILE A CA    1 ? 
ATOM   35   C C     . ILE A 1 16  ? 11.25787  -10.13885 34.51830  1.000 74.57123  ? 10  ILE A C     1 ? 
ATOM   36   O O     . ILE A 1 16  ? 10.13409  -9.91679  34.98782  1.000 79.71902  ? 10  ILE A O     1 ? 
ATOM   37   C CB    . ILE A 1 16  ? 11.59253  -12.57748 35.08788  1.000 72.80397  ? 10  ILE A CB    1 ? 
ATOM   38   C CG1   . ILE A 1 16  ? 12.71270  -13.61789 35.07744  1.000 72.39469  ? 10  ILE A CG1   1 ? 
ATOM   39   C CG2   . ILE A 1 16  ? 10.74320  -12.74292 33.83728  1.000 71.59585  ? 10  ILE A CG2   1 ? 
ATOM   40   C CD1   . ILE A 1 16  ? 12.28679  -14.97386 35.58833  1.000 75.41591  ? 10  ILE A CD1   1 ? 
ATOM   41   N N     . ILE A 1 17  ? 11.74033  -9.50120  33.45865  1.000 76.08963  ? 11  ILE A N     1 ? 
ATOM   42   C CA    . ILE A 1 17  ? 10.98320  -8.46616  32.76517  1.000 75.15282  ? 11  ILE A CA    1 ? 
ATOM   43   C C     . ILE A 1 17  ? 10.18806  -9.11540  31.64203  1.000 75.29372  ? 11  ILE A C     1 ? 
ATOM   44   O O     . ILE A 1 17  ? 10.73846  -9.88258  30.84330  1.000 70.89282  ? 11  ILE A O     1 ? 
ATOM   45   C CB    . ILE A 1 17  ? 11.91594  -7.37349  32.21434  1.000 73.89059  ? 11  ILE A CB    1 ? 
ATOM   46   C CG1   . ILE A 1 17  ? 12.78436  -6.77135  33.32274  1.000 73.22972  ? 11  ILE A CG1   1 ? 
ATOM   47   C CG2   . ILE A 1 17  ? 11.10789  -6.28203  31.53173  1.000 75.26204  ? 11  ILE A CG2   1 ? 
ATOM   48   C CD1   . ILE A 1 17  ? 12.04504  -6.47701  34.60273  1.000 74.25665  ? 11  ILE A CD1   1 ? 
ATOM   49   N N     . ILE A 1 18  ? 8.89407   -8.81769  31.57876  1.000 75.00355  ? 12  ILE A N     1 ? 
ATOM   50   C CA    . ILE A 1 18  ? 8.04749   -9.25015  30.47343  1.000 75.36520  ? 12  ILE A CA    1 ? 
ATOM   51   C C     . ILE A 1 18  ? 7.75065   -8.01383  29.63520  1.000 75.86414  ? 12  ILE A C     1 ? 
ATOM   52   O O     . ILE A 1 18  ? 6.97597   -7.14204  30.04880  1.000 76.12273  ? 12  ILE A O     1 ? 
ATOM   53   C CB    . ILE A 1 18  ? 6.75655   -9.92749  30.95429  1.000 71.84798  ? 12  ILE A CB    1 ? 
ATOM   54   C CG1   . ILE A 1 18  ? 7.07003   -11.16161 31.79407  1.000 74.96115  ? 12  ILE A CG1   1 ? 
ATOM   55   C CG2   . ILE A 1 18  ? 5.92776   -10.39056 29.77726  1.000 75.38676  ? 12  ILE A CG2   1 ? 
ATOM   56   C CD1   . ILE A 1 18  ? 5.82686   -11.85562 32.30657  1.000 58.51332  ? 12  ILE A CD1   1 ? 
ATOM   57   N N     . GLY A 1 19  ? 8.37855   -7.92840  28.46417  1.000 72.23446  ? 13  GLY A N     1 ? 
ATOM   58   C CA    . GLY A 1 19  ? 8.23245   -6.77554  27.59728  1.000 66.77893  ? 13  GLY A CA    1 ? 
ATOM   59   C C     . GLY A 1 19  ? 9.54457   -6.06002  27.34820  1.000 77.59565  ? 13  GLY A C     1 ? 
ATOM   60   O O     . GLY A 1 19  ? 10.32181  -5.83722  28.28120  1.000 79.88333  ? 13  GLY A O     1 ? 
ATOM   61   N N     . ALA A 1 20  ? 9.80745   -5.69576  26.09099  1.000 67.61775  ? 14  ALA A N     1 ? 
ATOM   62   C CA    . ALA A 1 20  ? 11.03400  -4.99697  25.72287  1.000 60.41358  ? 14  ALA A CA    1 ? 
ATOM   63   C C     . ALA A 1 20  ? 10.75378  -3.66783  25.03005  1.000 67.78994  ? 14  ALA A C     1 ? 
ATOM   64   O O     . ALA A 1 20  ? 11.59407  -3.18155  24.26623  1.000 64.96551  ? 14  ALA A O     1 ? 
ATOM   65   C CB    . ALA A 1 20  ? 11.91314  -5.88240  24.83711  1.000 48.96112  ? 14  ALA A CB    1 ? 
ATOM   66   N N     . GLY A 1 21  ? 9.58929   -3.07248  25.27653  1.000 67.61404  ? 15  GLY A N     1 ? 
ATOM   67   C CA    . GLY A 1 21  ? 9.26163   -1.76636  24.73836  1.000 64.92242  ? 15  GLY A CA    1 ? 
ATOM   68   C C     . GLY A 1 21  ? 9.80372   -0.64882  25.60241  1.000 68.23946  ? 15  GLY A C     1 ? 
ATOM   69   O O     . GLY A 1 21  ? 10.87155  -0.76476  26.21397  1.000 67.99523  ? 15  GLY A O     1 ? 
ATOM   70   N N     . PHE A 1 22  ? 9.05285   0.45349   25.66188  1.000 65.60662  ? 16  PHE A N     1 ? 
ATOM   71   C CA    . PHE A 1 22  ? 9.48082   1.60074   26.45771  1.000 62.75225  ? 16  PHE A CA    1 ? 
ATOM   72   C C     . PHE A 1 22  ? 9.61273   1.23244   27.93110  1.000 64.57306  ? 16  PHE A C     1 ? 
ATOM   73   O O     . PHE A 1 22  ? 10.62931  1.52903   28.56940  1.000 68.63998  ? 16  PHE A O     1 ? 
ATOM   74   C CB    . PHE A 1 22  ? 8.49832   2.75898   26.28103  1.000 69.13360  ? 16  PHE A CB    1 ? 
ATOM   75   C CG    . PHE A 1 22  ? 9.00425   3.85417   25.38693  1.000 76.82603  ? 16  PHE A CG    1 ? 
ATOM   76   C CD1   . PHE A 1 22  ? 9.78758   4.87726   25.89654  1.000 66.76296  ? 16  PHE A CD1   1 ? 
ATOM   77   C CD2   . PHE A 1 22  ? 8.68935   3.86579   24.03813  1.000 72.36359  ? 16  PHE A CD2   1 ? 
ATOM   78   C CE1   . PHE A 1 22  ? 10.25279  5.88861   25.07498  1.000 70.99414  ? 16  PHE A CE1   1 ? 
ATOM   79   C CE2   . PHE A 1 22  ? 9.15042   4.87378   23.21211  1.000 62.88144  ? 16  PHE A CE2   1 ? 
ATOM   80   C CZ    . PHE A 1 22  ? 9.93313   5.88642   23.73107  1.000 67.51334  ? 16  PHE A CZ    1 ? 
ATOM   81   N N     . GLY A 1 23  ? 8.59333   0.57608   28.48686  1.000 60.36001  ? 17  GLY A N     1 ? 
ATOM   82   C CA    . GLY A 1 23  ? 8.62244   0.25361   29.90491  1.000 64.83065  ? 17  GLY A CA    1 ? 
ATOM   83   C C     . GLY A 1 23  ? 9.64033   -0.81923  30.24292  1.000 69.03030  ? 17  GLY A C     1 ? 
ATOM   84   O O     . GLY A 1 23  ? 10.40041  -0.68962  31.20674  1.000 76.30621  ? 17  GLY A O     1 ? 
ATOM   85   N N     . GLY A 1 24  ? 9.66937   -1.89486  29.45346  1.000 76.20600  ? 18  GLY A N     1 ? 
ATOM   86   C CA    . GLY A 1 24  ? 10.57119  -2.99467  29.74676  1.000 67.40466  ? 18  GLY A CA    1 ? 
ATOM   87   C C     . GLY A 1 24  ? 12.03476  -2.63701  29.59201  1.000 67.15770  ? 18  GLY A C     1 ? 
ATOM   88   O O     . GLY A 1 24  ? 12.88735  -3.18754  30.29518  1.000 73.78282  ? 18  GLY A O     1 ? 
ATOM   89   N N     . LEU A 1 25  ? 12.35021  -1.71743  28.67774  1.000 68.67443  ? 19  LEU A N     1 ? 
ATOM   90   C CA    . LEU A 1 25  ? 13.74161  -1.32569  28.47682  1.000 70.79204  ? 19  LEU A CA    1 ? 
ATOM   91   C C     . LEU A 1 25  ? 14.26158  -0.52095  29.66135  1.000 73.75742  ? 19  LEU A C     1 ? 
ATOM   92   O O     . LEU A 1 25  ? 15.37114  -0.76401  30.15003  1.000 83.06994  ? 19  LEU A O     1 ? 
ATOM   93   C CB    . LEU A 1 25  ? 13.88454  -0.53077  27.17876  1.000 68.80890  ? 19  LEU A CB    1 ? 
ATOM   94   C CG    . LEU A 1 25  ? 13.97071  -1.35308  25.89054  1.000 72.25257  ? 19  LEU A CG    1 ? 
ATOM   95   C CD1   . LEU A 1 25  ? 14.02658  -0.44270  24.67309  1.000 71.37232  ? 19  LEU A CD1   1 ? 
ATOM   96   C CD2   . LEU A 1 25  ? 15.16618  -2.28761  25.91927  1.000 77.87075  ? 19  LEU A CD2   1 ? 
ATOM   97   N N     . TYR A 1 26  ? 13.47329  0.44517   30.13953  1.000 65.87076  ? 20  TYR A N     1 ? 
ATOM   98   C CA    . TYR A 1 26  ? 13.90919  1.23254   31.28730  1.000 70.19743  ? 20  TYR A CA    1 ? 
ATOM   99   C C     . TYR A 1 26  ? 13.81586  0.43605   32.58199  1.000 69.29098  ? 20  TYR A C     1 ? 
ATOM   100  O O     . TYR A 1 26  ? 14.57009  0.70104   33.52520  1.000 65.62879  ? 20  TYR A O     1 ? 
ATOM   101  C CB    . TYR A 1 26  ? 13.09444  2.52085   31.39363  1.000 56.00096  ? 20  TYR A CB    1 ? 
ATOM   102  C CG    . TYR A 1 26  ? 13.66981  3.50211   32.38783  1.000 53.57316  ? 20  TYR A CG    1 ? 
ATOM   103  C CD1   . TYR A 1 26  ? 15.04358  3.67352   32.50211  1.000 57.64436  ? 20  TYR A CD1   1 ? 
ATOM   104  C CD2   . TYR A 1 26  ? 12.84477  4.25521   33.21109  1.000 53.05331  ? 20  TYR A CD2   1 ? 
ATOM   105  C CE1   . TYR A 1 26  ? 15.58031  4.56382   33.40950  1.000 68.26669  ? 20  TYR A CE1   1 ? 
ATOM   106  C CE2   . TYR A 1 26  ? 13.37272  5.15283   34.12010  1.000 65.67657  ? 20  TYR A CE2   1 ? 
ATOM   107  C CZ    . TYR A 1 26  ? 14.74157  5.30172   34.21597  1.000 76.33045  ? 20  TYR A CZ    1 ? 
ATOM   108  O OH    . TYR A 1 26  ? 15.27560  6.19155   35.11990  1.000 75.45468  ? 20  TYR A OH    1 ? 
ATOM   109  N N     . SER A 1 27  ? 12.90116  -0.53423  32.65128  1.000 70.15834  ? 21  SER A N     1 ? 
ATOM   110  C CA    . SER A 1 27  ? 12.86923  -1.42763  33.80416  1.000 72.12339  ? 21  SER A CA    1 ? 
ATOM   111  C C     . SER A 1 27  ? 14.13833  -2.26579  33.87490  1.000 68.98578  ? 21  SER A C     1 ? 
ATOM   112  O O     . SER A 1 27  ? 14.66803  -2.51697  34.96351  1.000 64.32637  ? 21  SER A O     1 ? 
ATOM   113  C CB    . SER A 1 27  ? 11.63426  -2.32692  33.74251  1.000 65.94081  ? 21  SER A CB    1 ? 
ATOM   114  O OG    . SER A 1 27  ? 10.45480  -1.59996  34.03858  1.000 67.74312  ? 21  SER A OG    1 ? 
ATOM   115  N N     . LEU A 1 28  ? 14.64436  -2.70117  32.71953  1.000 74.35148  ? 22  LEU A N     1 ? 
ATOM   116  C CA    . LEU A 1 28  ? 15.88200  -3.47256  32.69139  1.000 75.94331  ? 22  LEU A CA    1 ? 
ATOM   117  C C     . LEU A 1 28  ? 17.07523  -2.60398  33.06956  1.000 71.75981  ? 22  LEU A C     1 ? 
ATOM   118  O O     . LEU A 1 28  ? 17.93450  -3.02114  33.85432  1.000 73.46103  ? 22  LEU A O     1 ? 
ATOM   119  C CB    . LEU A 1 28  ? 16.07874  -4.09100  31.30619  1.000 66.94226  ? 22  LEU A CB    1 ? 
ATOM   120  C CG    . LEU A 1 28  ? 17.44853  -4.68815  30.97181  1.000 73.45174  ? 22  LEU A CG    1 ? 
ATOM   121  C CD1   . LEU A 1 28  ? 17.87266  -5.72248  32.00624  1.000 79.11031  ? 22  LEU A CD1   1 ? 
ATOM   122  C CD2   . LEU A 1 28  ? 17.44001  -5.29125  29.57874  1.000 71.14905  ? 22  LEU A CD2   1 ? 
ATOM   123  N N     . LYS A 1 29  ? 17.14580  -1.39147  32.51537  1.000 85.34058  ? 23  LYS A N     1 ? 
ATOM   124  C CA    . LYS A 1 29  ? 18.25694  -0.49585  32.82170  1.000 76.92367  ? 23  LYS A CA    1 ? 
ATOM   125  C C     . LYS A 1 29  ? 18.31861  -0.19156  34.31249  1.000 78.45495  ? 23  LYS A C     1 ? 
ATOM   126  O O     . LYS A 1 29  ? 19.39481  -0.21486  34.92071  1.000 81.93971  ? 23  LYS A O     1 ? 
ATOM   127  C CB    . LYS A 1 29  ? 18.12445  0.79667   32.01310  1.000 70.30419  ? 23  LYS A CB    1 ? 
ATOM   128  C CG    . LYS A 1 29  ? 18.98462  1.95131   32.51748  1.000 71.95155  ? 23  LYS A CG    1 ? 
ATOM   129  C CD    . LYS A 1 29  ? 20.46395  1.58932   32.53557  1.000 80.19704  ? 23  LYS A CD    1 ? 
ATOM   130  C CE    . LYS A 1 29  ? 21.34479  2.82431   32.47705  1.000 81.24705  ? 23  LYS A CE    1 ? 
ATOM   131  N NZ    . LYS A 1 29  ? 22.77785  2.46362   32.29477  1.000 78.66711  ? 23  LYS A NZ    1 ? 
ATOM   132  N N     . LYS A 1 30  ? 17.16690  0.08586   34.92142  1.000 77.51538  ? 24  LYS A N     1 ? 
ATOM   133  C CA    . LYS A 1 30  ? 17.15386  0.49832   36.31981  1.000 76.98881  ? 24  LYS A CA    1 ? 
ATOM   134  C C     . LYS A 1 30  ? 17.58317  -0.63812  37.23823  1.000 77.34278  ? 24  LYS A C     1 ? 
ATOM   135  O O     . LYS A 1 30  ? 18.50189  -0.48129  38.05110  1.000 83.49934  ? 24  LYS A O     1 ? 
ATOM   136  C CB    . LYS A 1 30  ? 15.76345  1.00064   36.70080  1.000 80.11784  ? 24  LYS A CB    1 ? 
ATOM   137  C CG    . LYS A 1 30  ? 15.80793  2.12628   37.69944  1.000 77.89987  ? 24  LYS A CG    1 ? 
ATOM   138  C CD    . LYS A 1 30  ? 16.53020  3.30100   37.07468  1.000 81.65832  ? 24  LYS A CD    1 ? 
ATOM   139  C CE    . LYS A 1 30  ? 16.58104  4.48129   38.01015  1.000 87.23174  ? 24  LYS A CE    1 ? 
ATOM   140  N NZ    . LYS A 1 30  ? 17.29729  5.62571   37.38402  1.000 97.43041  ? 24  LYS A NZ    1 ? 
ATOM   141  N N     . LEU A 1 31  ? 16.93227  -1.79489  37.11463  1.000 74.58201  ? 25  LEU A N     1 ? 
ATOM   142  C CA    . LEU A 1 31  ? 17.18619  -2.89376  38.03837  1.000 74.27967  ? 25  LEU A CA    1 ? 
ATOM   143  C C     . LEU A 1 31  ? 18.59391  -3.45202  37.86863  1.000 81.25738  ? 25  LEU A C     1 ? 
ATOM   144  O O     . LEU A 1 31  ? 19.24571  -3.81233  38.85507  1.000 85.41846  ? 25  LEU A O     1 ? 
ATOM   145  C CB    . LEU A 1 31  ? 16.13635  -3.98509  37.83510  1.000 70.48592  ? 25  LEU A CB    1 ? 
ATOM   146  C CG    . LEU A 1 31  ? 14.69212  -3.52247  38.05168  1.000 69.18590  ? 25  LEU A CG    1 ? 
ATOM   147  C CD1   . LEU A 1 31  ? 13.73778  -4.69917  38.10376  1.000 65.47854  ? 25  LEU A CD1   1 ? 
ATOM   148  C CD2   . LEU A 1 31  ? 14.57720  -2.68765  39.31718  1.000 69.10118  ? 25  LEU A CD2   1 ? 
ATOM   149  N N     . ARG A 1 32  ? 19.08742  -3.51567  36.63092  1.000 77.99709  ? 26  ARG A N     1 ? 
ATOM   150  C CA    . ARG A 1 32  ? 20.40154  -4.10078  36.38445  1.000 75.60284  ? 26  ARG A CA    1 ? 
ATOM   151  C C     . ARG A 1 32  ? 21.52682  -3.11768  36.68800  1.000 80.48185  ? 26  ARG A C     1 ? 
ATOM   152  O O     . ARG A 1 32  ? 22.44354  -3.43064  37.45478  1.000 86.80059  ? 26  ARG A O     1 ? 
ATOM   153  C CB    . ARG A 1 32  ? 20.50077  -4.58328  34.93665  1.000 68.72894  ? 26  ARG A CB    1 ? 
ATOM   154  C CG    . ARG A 1 32  ? 21.80001  -5.30199  34.61781  1.000 75.73742  ? 26  ARG A CG    1 ? 
ATOM   155  C CD    . ARG A 1 32  ? 22.00431  -5.43927  33.11907  1.000 75.25191  ? 26  ARG A CD    1 ? 
ATOM   156  N NE    . ARG A 1 32  ? 22.49007  -4.20210  32.52002  1.000 83.49965  ? 26  ARG A NE    1 ? 
ATOM   157  C CZ    . ARG A 1 32  ? 22.79045  -4.05916  31.23649  1.000 89.77978  ? 26  ARG A CZ    1 ? 
ATOM   158  N NH1   . ARG A 1 32  ? 22.66540  -5.06120  30.38154  1.000 83.56831  ? 26  ARG A NH1   1 ? 
ATOM   159  N NH2   . ARG A 1 32  ? 23.22719  -2.88128  30.79964  1.000 81.73475  ? 26  ARG A NH2   1 ? 
ATOM   160  N N     . ASP A 1 33  ? 21.47810  -1.92685  36.09326  1.000 83.37174  ? 27  ASP A N     1 ? 
ATOM   161  C CA    . ASP A 1 33  ? 22.60508  -1.00465  36.16656  1.000 83.39980  ? 27  ASP A CA    1 ? 
ATOM   162  C C     . ASP A 1 33  ? 22.57582  -0.12363  37.40993  1.000 80.94102  ? 27  ASP A C     1 ? 
ATOM   163  O O     . ASP A 1 33  ? 23.62542  0.12188   38.01377  1.000 85.73484  ? 27  ASP A O     1 ? 
ATOM   164  C CB    . ASP A 1 33  ? 22.64730  -0.12956  34.91160  1.000 80.81662  ? 27  ASP A CB    1 ? 
ATOM   165  C CG    . ASP A 1 33  ? 23.32868  -0.81833  33.74535  1.000 89.26964  ? 27  ASP A CG    1 ? 
ATOM   166  O OD1   . ASP A 1 33  ? 23.45489  -0.19037  32.67291  1.000 87.40540  ? 27  ASP A OD1   1 ? 
ATOM   167  O OD2   . ASP A 1 33  ? 23.73747  -1.98848  33.90154  1.000 86.27664  ? 27  ASP A OD2   1 ? 
ATOM   168  N N     . ASP A 1 34  ? 21.40230  0.36303   37.80760  1.000 76.36875  ? 28  ASP A N     1 ? 
ATOM   169  C CA    . ASP A 1 34  ? 21.30599  1.26345   38.94818  1.000 76.37189  ? 28  ASP A CA    1 ? 
ATOM   170  C C     . ASP A 1 34  ? 21.08404  0.54139   40.27063  1.000 80.99620  ? 28  ASP A C     1 ? 
ATOM   171  O O     . ASP A 1 34  ? 21.13002  1.18742   41.32327  1.000 83.70654  ? 28  ASP A O     1 ? 
ATOM   172  C CB    . ASP A 1 34  ? 20.18257  2.28277   38.72539  1.000 81.36780  ? 28  ASP A CB    1 ? 
ATOM   173  C CG    . ASP A 1 34  ? 20.52816  3.30436   37.65860  1.000 84.48663  ? 28  ASP A CG    1 ? 
ATOM   174  O OD1   . ASP A 1 34  ? 21.66489  3.26505   37.14345  1.000 88.65288  ? 28  ASP A OD1   1 ? 
ATOM   175  O OD2   . ASP A 1 34  ? 19.66794  4.14985   37.33778  1.000 86.78694  ? 28  ASP A OD2   1 ? 
ATOM   176  N N     . PHE A 1 35  ? 20.84501  -0.77151  40.24946  1.000 81.17736  ? 29  PHE A N     1 ? 
ATOM   177  C CA    . PHE A 1 35  ? 20.66793  -1.53452  41.47579  1.000 77.79623  ? 29  PHE A CA    1 ? 
ATOM   178  C C     . PHE A 1 35  ? 21.44301  -2.84595  41.49518  1.000 80.18319  ? 29  PHE A C     1 ? 
ATOM   179  O O     . PHE A 1 35  ? 21.30457  -3.60831  42.45819  1.000 86.62097  ? 29  PHE A O     1 ? 
ATOM   180  C CB    . PHE A 1 35  ? 19.17767  -1.81906  41.72530  1.000 80.70078  ? 29  PHE A CB    1 ? 
ATOM   181  C CG    . PHE A 1 35  ? 18.41226  -0.63463  42.25387  1.000 81.97558  ? 29  PHE A CG    1 ? 
ATOM   182  C CD1   . PHE A 1 35  ? 18.01544  0.38946   41.40781  1.000 78.67003  ? 29  PHE A CD1   1 ? 
ATOM   183  C CD2   . PHE A 1 35  ? 18.09786  -0.54219  43.59988  1.000 84.61223  ? 29  PHE A CD2   1 ? 
ATOM   184  C CE1   . PHE A 1 35  ? 17.31350  1.47820   41.89315  1.000 81.51255  ? 29  PHE A CE1   1 ? 
ATOM   185  C CE2   . PHE A 1 35  ? 17.39663  0.54398   44.09062  1.000 77.62168  ? 29  PHE A CE2   1 ? 
ATOM   186  C CZ    . PHE A 1 35  ? 17.00441  1.55487   43.23661  1.000 77.28767  ? 29  PHE A CZ    1 ? 
ATOM   187  N N     . ASN A 1 36  ? 22.24130  -3.13261  40.46351  1.000 89.18647  ? 30  ASN A N     1 ? 
ATOM   188  C CA    . ASN A 1 36  ? 23.15049  -4.28220  40.44048  1.000 85.92772  ? 30  ASN A CA    1 ? 
ATOM   189  C C     . ASN A 1 36  ? 22.41553  -5.61046  40.60729  1.000 89.27494  ? 30  ASN A C     1 ? 
ATOM   190  O O     . ASN A 1 36  ? 22.96631  -6.57158  41.14969  1.000 103.89452 ? 30  ASN A O     1 ? 
ATOM   191  C CB    . ASN A 1 36  ? 24.24433  -4.14297  41.50381  1.000 92.80958  ? 30  ASN A CB    1 ? 
ATOM   192  C CG    . ASN A 1 36  ? 25.04867  -2.86744  41.34800  1.000 103.38062 ? 30  ASN A CG    1 ? 
ATOM   193  O OD1   . ASN A 1 36  ? 24.49804  -1.76658  41.36666  1.000 98.67023  ? 30  ASN A OD1   1 ? 
ATOM   194  N ND2   . ASN A 1 36  ? 26.35984  -3.00968  41.19274  1.000 109.43883 ? 30  ASN A ND2   1 ? 
ATOM   195  N N     . LEU A 1 37  ? 21.17456  -5.68241  40.13893  1.000 84.04058  ? 31  LEU A N     1 ? 
ATOM   196  C CA    . LEU A 1 37  ? 20.39063  -6.90444  40.22879  1.000 85.54608  ? 31  LEU A CA    1 ? 
ATOM   197  C C     . LEU A 1 37  ? 20.59803  -7.76229  38.98696  1.000 81.27553  ? 31  LEU A C     1 ? 
ATOM   198  O O     . LEU A 1 37  ? 20.85967  -7.25304  37.89381  1.000 77.36587  ? 31  LEU A O     1 ? 
ATOM   199  C CB    . LEU A 1 37  ? 18.90369  -6.58253  40.39063  1.000 76.97839  ? 31  LEU A CB    1 ? 
ATOM   200  C CG    . LEU A 1 37  ? 18.46524  -5.90825  41.69210  1.000 70.75159  ? 31  LEU A CG    1 ? 
ATOM   201  C CD1   . LEU A 1 37  ? 16.94905  -5.91164  41.80985  1.000 74.75327  ? 31  LEU A CD1   1 ? 
ATOM   202  C CD2   . LEU A 1 37  ? 19.09831  -6.58981  42.89371  1.000 86.97846  ? 31  LEU A CD2   1 ? 
ATOM   203  N N     . LYS A 1 38  ? 20.48579  -9.07771  39.16540  1.000 84.08982  ? 32  LYS A N     1 ? 
ATOM   204  C CA    . LYS A 1 38  ? 20.49452  -9.99692  38.03191  1.000 82.95490  ? 32  LYS A CA    1 ? 
ATOM   205  C C     . LYS A 1 38  ? 19.09213  -10.02069 37.43125  1.000 84.73815  ? 32  LYS A C     1 ? 
ATOM   206  O O     . LYS A 1 38  ? 18.13609  -10.47868 38.06636  1.000 83.76920  ? 32  LYS A O     1 ? 
ATOM   207  C CB    . LYS A 1 38  ? 20.97334  -11.38729 38.45289  1.000 78.79289  ? 32  LYS A CB    1 ? 
ATOM   208  C CG    . LYS A 1 38  ? 20.14693  -12.09141 39.52352  1.000 83.38714  ? 32  LYS A CG    1 ? 
ATOM   209  C CD    . LYS A 1 38  ? 20.84112  -13.34508 40.03436  1.000 94.44289  ? 32  LYS A CD    1 ? 
ATOM   210  C CE    . LYS A 1 38  ? 20.23803  -13.81220 41.35108  1.000 87.01908  ? 32  LYS A CE    1 ? 
ATOM   211  N NZ    . LYS A 1 38  ? 21.07828  -14.84459 42.01977  1.000 78.98378  ? 32  LYS A NZ    1 ? 
ATOM   212  N N     . VAL A 1 39  ? 18.95838  -9.48609  36.21976  1.000 85.84510  ? 33  VAL A N     1 ? 
ATOM   213  C CA    . VAL A 1 39  ? 17.66243  -9.31926  35.57758  1.000 82.98181  ? 33  VAL A CA    1 ? 
ATOM   214  C C     . VAL A 1 39  ? 17.70335  -9.95667  34.19740  1.000 81.52967  ? 33  VAL A C     1 ? 
ATOM   215  O O     . VAL A 1 39  ? 18.73234  -9.94463  33.51414  1.000 83.73821  ? 33  VAL A O     1 ? 
ATOM   216  C CB    . VAL A 1 39  ? 17.25798  -7.82961  35.46985  1.000 76.34540  ? 33  VAL A CB    1 ? 
ATOM   217  C CG1   . VAL A 1 39  ? 15.75144  -7.69290  35.31478  1.000 79.09995  ? 33  VAL A CG1   1 ? 
ATOM   218  C CG2   . VAL A 1 39  ? 17.74765  -7.04587  36.67960  1.000 74.49450  ? 33  VAL A CG2   1 ? 
ATOM   219  N N     . ARG A 1 40  ? 16.56926  -10.52157 33.79082  1.000 81.66582  ? 34  ARG A N     1 ? 
ATOM   220  C CA    . ARG A 1 40  ? 16.38898  -11.04229 32.44353  1.000 81.73222  ? 34  ARG A CA    1 ? 
ATOM   221  C C     . ARG A 1 40  ? 15.06733  -10.53422 31.89332  1.000 74.58566  ? 34  ARG A C     1 ? 
ATOM   222  O O     . ARG A 1 40  ? 14.03741  -10.60932 32.57123  1.000 69.95081  ? 34  ARG A O     1 ? 
ATOM   223  C CB    . ARG A 1 40  ? 16.41808  -12.57339 32.41368  1.000 83.61664  ? 34  ARG A CB    1 ? 
ATOM   224  C CG    . ARG A 1 40  ? 16.62190  -13.14012 31.01698  1.000 85.75098  ? 34  ARG A CG    1 ? 
ATOM   225  C CD    . ARG A 1 40  ? 17.58805  -14.30928 31.01860  1.000 90.59185  ? 34  ARG A CD    1 ? 
ATOM   226  N NE    . ARG A 1 40  ? 18.11833  -14.57305 29.68678  1.000 103.28846 ? 34  ARG A NE    1 ? 
ATOM   227  C CZ    . ARG A 1 40  ? 19.25968  -14.08015 29.22565  1.000 100.95704 ? 34  ARG A CZ    1 ? 
ATOM   228  N NH1   . ARG A 1 40  ? 20.02323  -13.29420 29.96743  1.000 91.91464  ? 34  ARG A NH1   1 ? 
ATOM   229  N NH2   . ARG A 1 40  ? 19.64501  -14.38351 27.98952  1.000 92.25908  ? 34  ARG A NH2   1 ? 
ATOM   230  N N     . ALA A 1 41  ? 15.10136  -10.01400 30.67261  1.000 78.60788  ? 35  ALA A N     1 ? 
ATOM   231  C CA    . ALA A 1 41  ? 13.91121  -9.53398  29.99281  1.000 77.88134  ? 35  ALA A CA    1 ? 
ATOM   232  C C     . ALA A 1 41  ? 13.53538  -10.49116 28.87057  1.000 78.15902  ? 35  ALA A C     1 ? 
ATOM   233  O O     . ALA A 1 41  ? 14.39475  -11.14447 28.27244  1.000 76.59980  ? 35  ALA A O     1 ? 
ATOM   234  C CB    . ALA A 1 41  ? 14.12427  -8.12502  29.43320  1.000 70.74805  ? 35  ALA A CB    1 ? 
ATOM   235  N N     . PHE A 1 42  ? 12.23831  -10.57731 28.59781  1.000 74.86153  ? 36  PHE A N     1 ? 
ATOM   236  C CA    . PHE A 1 42  ? 11.72558  -11.42830 27.53836  1.000 74.58567  ? 36  PHE A CA    1 ? 
ATOM   237  C C     . PHE A 1 42  ? 10.79454  -10.62180 26.64678  1.000 76.65402  ? 36  PHE A C     1 ? 
ATOM   238  O O     . PHE A 1 42  ? 10.23786  -9.59956  27.05620  1.000 74.58746  ? 36  PHE A O     1 ? 
ATOM   239  C CB    . PHE A 1 42  ? 10.98250  -12.64918 28.09985  1.000 79.00027  ? 36  PHE A CB    1 ? 
ATOM   240  C CG    . PHE A 1 42  ? 11.87716  -13.65014 28.77124  1.000 82.60929  ? 36  PHE A CG    1 ? 
ATOM   241  C CD1   . PHE A 1 42  ? 12.48358  -14.65527 28.03765  1.000 79.31511  ? 36  PHE A CD1   1 ? 
ATOM   242  C CD2   . PHE A 1 42  ? 12.10558  -13.59165 30.13640  1.000 85.48833  ? 36  PHE A CD2   1 ? 
ATOM   243  C CE1   . PHE A 1 42  ? 13.30531  -15.57960 28.65127  1.000 82.04634  ? 36  PHE A CE1   1 ? 
ATOM   244  C CE2   . PHE A 1 42  ? 12.92684  -14.51411 30.75629  1.000 78.04623  ? 36  PHE A CE2   1 ? 
ATOM   245  C CZ    . PHE A 1 42  ? 13.52732  -15.50934 30.01209  1.000 97.30176  ? 36  PHE A CZ    1 ? 
ATOM   246  N N     . ASP A 1 43  ? 10.62436  -11.10438 25.41877  1.000 78.61363  ? 37  ASP A N     1 ? 
ATOM   247  C CA    . ASP A 1 43  ? 9.67177   -10.51939 24.48786  1.000 76.30930  ? 37  ASP A CA    1 ? 
ATOM   248  C C     . ASP A 1 43  ? 9.44648   -11.49440 23.34365  1.000 79.61783  ? 37  ASP A C     1 ? 
ATOM   249  O O     . ASP A 1 43  ? 10.38401  -12.15770 22.89279  1.000 78.44118  ? 37  ASP A O     1 ? 
ATOM   250  C CB    . ASP A 1 43  ? 10.15698  -9.16907  23.94592  1.000 79.80833  ? 37  ASP A CB    1 ? 
ATOM   251  C CG    . ASP A 1 43  ? 9.01146   -8.22502  23.62957  1.000 79.29059  ? 37  ASP A CG    1 ? 
ATOM   252  O OD1   . ASP A 1 43  ? 8.18725   -8.56421  22.75425  1.000 73.45090  ? 37  ASP A OD1   1 ? 
ATOM   253  O OD2   . ASP A 1 43  ? 8.93191   -7.14738  24.25650  1.000 73.92458  ? 37  ASP A OD2   1 ? 
ATOM   254  N N     . ARG A 1 44  ? 8.19468   -11.57805 22.88684  1.000 81.10134  ? 38  ARG A N     1 ? 
ATOM   255  C CA    . ARG A 1 44  ? 7.88596   -12.39299 21.71724  1.000 83.74207  ? 38  ARG A CA    1 ? 
ATOM   256  C C     . ARG A 1 44  ? 8.58219   -11.86394 20.47113  1.000 82.59749  ? 38  ARG A C     1 ? 
ATOM   257  O O     . ARG A 1 44  ? 8.82728   -12.62229 19.52590  1.000 100.90679 ? 38  ARG A O     1 ? 
ATOM   258  C CB    . ARG A 1 44  ? 6.37378   -12.43876 21.49750  1.000 86.46628  ? 38  ARG A CB    1 ? 
ATOM   259  C CG    . ARG A 1 44  ? 5.74183   -13.79872 21.72779  1.000 92.39228  ? 38  ARG A CG    1 ? 
ATOM   260  C CD    . ARG A 1 44  ? 4.39897   -13.89509 21.02188  1.000 97.03681  ? 38  ARG A CD    1 ? 
ATOM   261  N NE    . ARG A 1 44  ? 4.43913   -14.79712 19.87719  1.000 121.64810 ? 38  ARG A NE    1 ? 
ATOM   262  C CZ    . ARG A 1 44  ? 3.56973   -14.77458 18.87602  1.000 117.45821 ? 38  ARG A CZ    1 ? 
ATOM   263  N NH1   . ARG A 1 44  ? 2.57907   -13.89813 18.84021  1.000 104.81452 ? 38  ARG A NH1   1 ? 
ATOM   264  N NH2   . ARG A 1 44  ? 3.69774   -15.65287 17.88549  1.000 106.47107 ? 38  ARG A NH2   1 ? 
ATOM   265  N N     . ALA A 1 45  ? 8.91201   -10.57495 20.45488  1.000 80.59138  ? 39  ALA A N     1 ? 
ATOM   266  C CA    . ALA A 1 45  ? 9.53033   -9.94941  19.29807  1.000 77.80356  ? 39  ALA A CA    1 ? 
ATOM   267  C C     . ALA A 1 45  ? 10.96820  -10.43616 19.12902  1.000 74.33248  ? 39  ALA A C     1 ? 
ATOM   268  O O     . ALA A 1 45  ? 11.49900  -11.20702 19.93355  1.000 80.92832  ? 39  ALA A O     1 ? 
ATOM   269  C CB    . ALA A 1 45  ? 9.48850   -8.43008  19.43749  1.000 64.51936  ? 39  ALA A CB    1 ? 
ATOM   270  N N     . THR A 1 46  ? 11.60360  -9.97351  18.05321  1.000 67.97379  ? 40  THR A N     1 ? 
ATOM   271  C CA    . THR A 1 46  ? 13.01095  -10.24038 17.78942  1.000 68.75464  ? 40  THR A CA    1 ? 
ATOM   272  C C     . THR A 1 46  ? 13.86921  -8.99137  17.94523  1.000 75.17121  ? 40  THR A C     1 ? 
ATOM   273  O O     . THR A 1 46  ? 15.05581  -9.01593  17.60124  1.000 72.70197  ? 40  THR A O     1 ? 
ATOM   274  C CB    . THR A 1 46  ? 13.18889  -10.82883 16.38732  1.000 72.67163  ? 40  THR A CB    1 ? 
ATOM   275  O OG1   . THR A 1 46  ? 13.35165  -9.76802  15.43817  1.000 75.85927  ? 40  THR A OG1   1 ? 
ATOM   276  C CG2   . THR A 1 46  ? 11.97601  -11.66383 16.00013  1.000 78.67120  ? 40  THR A CG2   1 ? 
ATOM   277  N N     . GLU A 1 47  ? 13.29528  -7.90393  18.45522  1.000 77.18058  ? 41  GLU A N     1 ? 
ATOM   278  C CA    . GLU A 1 47  ? 14.00796  -6.64841  18.64306  1.000 73.00683  ? 41  GLU A CA    1 ? 
ATOM   279  C C     . GLU A 1 47  ? 13.19809  -5.78441  19.59936  1.000 72.80462  ? 41  GLU A C     1 ? 
ATOM   280  O O     . GLU A 1 47  ? 11.98249  -5.94877  19.73218  1.000 69.82926  ? 41  GLU A O     1 ? 
ATOM   281  C CB    . GLU A 1 47  ? 14.24143  -5.93157  17.30439  1.000 72.31846  ? 41  GLU A CB    1 ? 
ATOM   282  C CG    . GLU A 1 47  ? 15.00511  -4.60714  17.37973  1.000 78.32465  ? 41  GLU A CG    1 ? 
ATOM   283  C CD    . GLU A 1 47  ? 16.44862  -4.76650  17.83188  1.000 85.44099  ? 41  GLU A CD    1 ? 
ATOM   284  O OE1   . GLU A 1 47  ? 16.68058  -5.08054  19.01914  1.000 81.13321  ? 41  GLU A OE1   1 ? 
ATOM   285  O OE2   . GLU A 1 47  ? 17.35635  -4.57222  16.99579  1.000 80.85566  ? 41  GLU A OE2   1 ? 
ATOM   286  N N     . VAL A 1 48  ? 13.89174  -4.86902  20.27607  1.000 71.79350  ? 42  VAL A N     1 ? 
ATOM   287  C CA    . VAL A 1 48  ? 13.25799  -3.94778  21.21374  1.000 76.39499  ? 42  VAL A CA    1 ? 
ATOM   288  C C     . VAL A 1 48  ? 12.32501  -3.00943  20.45883  1.000 81.51424  ? 42  VAL A C     1 ? 
ATOM   289  O O     . VAL A 1 48  ? 12.38188  -2.91486  19.22753  1.000 67.39581  ? 42  VAL A O     1 ? 
ATOM   290  C CB    . VAL A 1 48  ? 14.31014  -3.15307  22.00933  1.000 73.06552  ? 42  VAL A CB    1 ? 
ATOM   291  C CG1   . VAL A 1 48  ? 15.44884  -4.06375  22.43990  1.000 72.71248  ? 42  VAL A CG1   1 ? 
ATOM   292  C CG2   . VAL A 1 48  ? 14.83578  -1.98750  21.18209  1.000 75.56518  ? 42  VAL A CG2   1 ? 
ATOM   293  N N     . GLY A 1 49  ? 11.46033  -2.31110  21.19071  1.000 68.40390  ? 43  GLY A N     1 ? 
ATOM   294  C CA    . GLY A 1 49  ? 10.55063  -1.36369  20.57823  1.000 65.30811  ? 43  GLY A CA    1 ? 
ATOM   295  C C     . GLY A 1 49  ? 9.11800   -1.50741  21.04697  1.000 71.23022  ? 43  GLY A C     1 ? 
ATOM   296  O O     . GLY A 1 49  ? 8.40174   -0.51161  21.19134  1.000 67.96805  ? 43  GLY A O     1 ? 
ATOM   297  N N     . GLY A 1 50  ? 8.68985   -2.74152  21.28863  1.000 70.04091  ? 44  GLY A N     1 ? 
ATOM   298  C CA    . GLY A 1 50  ? 7.31515   -2.96480  21.70684  1.000 67.14872  ? 44  GLY A CA    1 ? 
ATOM   299  C C     . GLY A 1 50  ? 6.35656   -2.68284  20.56754  1.000 67.25941  ? 44  GLY A C     1 ? 
ATOM   300  O O     . GLY A 1 50  ? 6.52547   -3.18369  19.45001  1.000 64.53812  ? 44  GLY A O     1 ? 
ATOM   301  N N     . THR A 1 51  ? 5.33596   -1.86475  20.84508  1.000 68.32863  ? 45  THR A N     1 ? 
ATOM   302  C CA    . THR A 1 51  ? 4.38168   -1.48203  19.80912  1.000 69.53933  ? 45  THR A CA    1 ? 
ATOM   303  C C     . THR A 1 51  ? 5.05627   -0.79726  18.62967  1.000 67.82753  ? 45  THR A C     1 ? 
ATOM   304  O O     . THR A 1 51  ? 4.52332   -0.83617  17.51546  1.000 78.23950  ? 45  THR A O     1 ? 
ATOM   305  C CB    . THR A 1 51  ? 3.30414   -0.55921  20.38491  1.000 77.74724  ? 45  THR A CB    1 ? 
ATOM   306  O OG1   . THR A 1 51  ? 3.89840   0.35618   21.31423  1.000 83.03161  ? 45  THR A OG1   1 ? 
ATOM   307  C CG2   . THR A 1 51  ? 2.22131   -1.36681  21.08415  1.000 81.45750  ? 45  THR A CG2   1 ? 
ATOM   308  N N     . TRP A 1 52  ? 6.21421   -0.17626  18.84723  1.000 67.03726  ? 46  TRP A N     1 ? 
ATOM   309  C CA    . TRP A 1 52  ? 6.94531   0.47555   17.77116  1.000 64.98651  ? 46  TRP A CA    1 ? 
ATOM   310  C C     . TRP A 1 52  ? 7.73250   -0.50426  16.91328  1.000 64.36692  ? 46  TRP A C     1 ? 
ATOM   311  O O     . TRP A 1 52  ? 8.20589   -0.11970  15.83849  1.000 59.65573  ? 46  TRP A O     1 ? 
ATOM   312  C CB    . TRP A 1 52  ? 7.87115   1.54091   18.35549  1.000 59.53210  ? 46  TRP A CB    1 ? 
ATOM   313  C CG    . TRP A 1 52  ? 7.10275   2.65408   18.98498  1.000 59.50037  ? 46  TRP A CG    1 ? 
ATOM   314  C CD1   . TRP A 1 52  ? 6.91719   2.87669   20.31867  1.000 61.87452  ? 46  TRP A CD1   1 ? 
ATOM   315  C CD2   . TRP A 1 52  ? 6.39101   3.68994   18.30165  1.000 65.38806  ? 46  TRP A CD2   1 ? 
ATOM   316  N NE1   . TRP A 1 52  ? 6.14193   3.99581   20.50702  1.000 67.76311  ? 46  TRP A NE1   1 ? 
ATOM   317  C CE2   . TRP A 1 52  ? 5.80648   4.51316   19.28316  1.000 68.79225  ? 46  TRP A CE2   1 ? 
ATOM   318  C CE3   . TRP A 1 52  ? 6.19783   4.00563   16.95364  1.000 56.46976  ? 46  TRP A CE3   1 ? 
ATOM   319  C CZ2   . TRP A 1 52  ? 5.04065   5.62946   18.95876  1.000 67.15321  ? 46  TRP A CZ2   1 ? 
ATOM   320  C CZ3   . TRP A 1 52  ? 5.43891   5.11373   16.63448  1.000 58.97862  ? 46  TRP A CZ3   1 ? 
ATOM   321  C CH2   . TRP A 1 52  ? 4.87155   5.91355   17.63174  1.000 69.54692  ? 46  TRP A CH2   1 ? 
ATOM   322  N N     . PHE A 1 53  ? 7.88745   -1.74912  17.36082  1.000 65.80825  ? 47  PHE A N     1 ? 
ATOM   323  C CA    . PHE A 1 53  ? 8.39506   -2.81045  16.50301  1.000 66.03642  ? 47  PHE A CA    1 ? 
ATOM   324  C C     . PHE A 1 53  ? 7.27567   -3.53420  15.76988  1.000 60.48416  ? 47  PHE A C     1 ? 
ATOM   325  O O     . PHE A 1 53  ? 7.46773   -3.96453  14.62670  1.000 70.49701  ? 47  PHE A O     1 ? 
ATOM   326  C CB    . PHE A 1 53  ? 9.20456   -3.81889  17.32648  1.000 67.31445  ? 47  PHE A CB    1 ? 
ATOM   327  C CG    . PHE A 1 53  ? 9.51573   -5.09469  16.59104  1.000 61.41492  ? 47  PHE A CG    1 ? 
ATOM   328  C CD1   . PHE A 1 53  ? 10.57079  -5.15333  15.69546  1.000 64.06779  ? 47  PHE A CD1   1 ? 
ATOM   329  C CD2   . PHE A 1 53  ? 8.74859   -6.23192  16.78898  1.000 53.33372  ? 47  PHE A CD2   1 ? 
ATOM   330  C CE1   . PHE A 1 53  ? 10.85862  -6.32234  15.01644  1.000 59.82437  ? 47  PHE A CE1   1 ? 
ATOM   331  C CE2   . PHE A 1 53  ? 9.02950   -7.40237  16.11031  1.000 60.34925  ? 47  PHE A CE2   1 ? 
ATOM   332  C CZ    . PHE A 1 53  ? 10.08686  -7.44801  15.22449  1.000 59.70195  ? 47  PHE A CZ    1 ? 
ATOM   333  N N     . TRP A 1 54  ? 6.10675   -3.66347  16.40163  1.000 66.20893  ? 48  TRP A N     1 ? 
ATOM   334  C CA    . TRP A 1 54  ? 5.01040   -4.42872  15.81894  1.000 66.84687  ? 48  TRP A CA    1 ? 
ATOM   335  C C     . TRP A 1 54  ? 4.21954   -3.61208  14.80305  1.000 66.54303  ? 48  TRP A C     1 ? 
ATOM   336  O O     . TRP A 1 54  ? 3.85455   -4.12705  13.74041  1.000 76.14134  ? 48  TRP A O     1 ? 
ATOM   337  C CB    . TRP A 1 54  ? 4.07857   -4.92913  16.92391  1.000 71.22675  ? 48  TRP A CB    1 ? 
ATOM   338  C CG    . TRP A 1 54  ? 4.70150   -5.92341  17.85688  1.000 72.01705  ? 48  TRP A CG    1 ? 
ATOM   339  C CD1   . TRP A 1 54  ? 4.99187   -5.73702  19.17700  1.000 66.13086  ? 48  TRP A CD1   1 ? 
ATOM   340  C CD2   . TRP A 1 54  ? 5.09785   -7.26446  17.54517  1.000 70.66544  ? 48  TRP A CD2   1 ? 
ATOM   341  N NE1   . TRP A 1 54  ? 5.55074   -6.87509  19.70490  1.000 72.08401  ? 48  TRP A NE1   1 ? 
ATOM   342  C CE2   . TRP A 1 54  ? 5.62588   -7.82809  18.72359  1.000 73.66790  ? 48  TRP A CE2   1 ? 
ATOM   343  C CE3   . TRP A 1 54  ? 5.06005   -8.04222  16.38398  1.000 76.54534  ? 48  TRP A CE3   1 ? 
ATOM   344  C CZ2   . TRP A 1 54  ? 6.11033   -9.13267  18.77450  1.000 80.41783  ? 48  TRP A CZ2   1 ? 
ATOM   345  C CZ3   . TRP A 1 54  ? 5.54309   -9.33720  16.43674  1.000 72.51945  ? 48  TRP A CZ3   1 ? 
ATOM   346  C CH2   . TRP A 1 54  ? 6.06185   -9.86875  17.62314  1.000 82.68179  ? 48  TRP A CH2   1 ? 
ATOM   347  N N     . ASN A 1 55  ? 3.94258   -2.34661  15.11026  1.000 62.70397  ? 49  ASN A N     1 ? 
ATOM   348  C CA    . ASN A 1 55  ? 3.05580   -1.50926  14.30348  1.000 69.97141  ? 49  ASN A CA    1 ? 
ATOM   349  C C     . ASN A 1 55  ? 3.89722   -0.68483  13.33552  1.000 62.10860  ? 49  ASN A C     1 ? 
ATOM   350  O O     . ASN A 1 55  ? 4.49241   0.32382   13.71969  1.000 69.28319  ? 49  ASN A O     1 ? 
ATOM   351  C CB    . ASN A 1 55  ? 2.20728   -0.61178  15.19819  1.000 66.66199  ? 49  ASN A CB    1 ? 
ATOM   352  C CG    . ASN A 1 55  ? 1.33231   -1.39949  16.15254  1.000 81.49975  ? 49  ASN A CG    1 ? 
ATOM   353  O OD1   . ASN A 1 55  ? 0.38695   -2.06968  15.73770  1.000 87.57003  ? 49  ASN A OD1   1 ? 
ATOM   354  N ND2   . ASN A 1 55  ? 1.64535   -1.32354  17.44092  1.000 88.06689  ? 49  ASN A ND2   1 ? 
ATOM   355  N N     . GLN A 1 56  ? 3.93293   -1.10708  12.07403  1.000 61.29689  ? 50  GLN A N     1 ? 
ATOM   356  C CA    . GLN A 1 56  ? 4.65503   -0.39998  11.02230  1.000 67.25344  ? 50  GLN A CA    1 ? 
ATOM   357  C C     . GLN A 1 56  ? 3.73587   -0.10480  9.84496   1.000 65.57434  ? 50  GLN A C     1 ? 
ATOM   358  O O     . GLN A 1 56  ? 4.14216   -0.16804  8.68050   1.000 60.94770  ? 50  GLN A O     1 ? 
ATOM   359  C CB    . GLN A 1 56  ? 5.87923   -1.19207  10.56941  1.000 67.69456  ? 50  GLN A CB    1 ? 
ATOM   360  C CG    . GLN A 1 56  ? 5.59097   -2.64088  10.21582  1.000 71.83240  ? 50  GLN A CG    1 ? 
ATOM   361  C CD    . GLN A 1 56  ? 6.84506   -3.49169  10.19225  1.000 97.91633  ? 50  GLN A CD    1 ? 
ATOM   362  O OE1   . GLN A 1 56  ? 7.84365   -3.16340  10.83358  1.000 85.27394  ? 50  GLN A OE1   1 ? 
ATOM   363  N NE2   . GLN A 1 56  ? 6.80041   -4.59182  9.44943   1.000 95.98512  ? 50  GLN A NE2   1 ? 
ATOM   364  N N     . TYR A 1 57  ? 2.47900   0.22477   10.13393  1.000 60.76383  ? 51  TYR A N     1 ? 
ATOM   365  C CA    . TYR A 1 57  ? 1.52977   0.56202   9.08889   1.000 65.53573  ? 51  TYR A CA    1 ? 
ATOM   366  C C     . TYR A 1 57  ? 1.84481   1.94416   8.51613   1.000 59.75736  ? 51  TYR A C     1 ? 
ATOM   367  O O     . TYR A 1 57  ? 2.54469   2.74093   9.14533   1.000 54.27172  ? 51  TYR A O     1 ? 
ATOM   368  C CB    . TYR A 1 57  ? 0.10348   0.51606   9.63685   1.000 66.58134  ? 51  TYR A CB    1 ? 
ATOM   369  C CG    . TYR A 1 57  ? -0.13503  1.38665   10.85083  1.000 60.31758  ? 51  TYR A CG    1 ? 
ATOM   370  C CD1   . TYR A 1 57  ? -0.46228  2.72927   10.71385  1.000 57.04750  ? 51  TYR A CD1   1 ? 
ATOM   371  C CD2   . TYR A 1 57  ? -0.04447  0.86278   12.13366  1.000 57.08603  ? 51  TYR A CD2   1 ? 
ATOM   372  C CE1   . TYR A 1 57  ? -0.68720  3.52635   11.81737  1.000 62.08484  ? 51  TYR A CE1   1 ? 
ATOM   373  C CE2   . TYR A 1 57  ? -0.26635  1.65349   13.24487  1.000 55.58631  ? 51  TYR A CE2   1 ? 
ATOM   374  C CZ    . TYR A 1 57  ? -0.58691  2.98438   13.08027  1.000 59.89172  ? 51  TYR A CZ    1 ? 
ATOM   375  O OH    . TYR A 1 57  ? -0.81008  3.77742   14.18157  1.000 63.80326  ? 51  TYR A OH    1 ? 
ATOM   376  N N     . PRO A 1 58  ? 1.35170   2.24496   7.31344   1.000 65.85445  ? 52  PRO A N     1 ? 
ATOM   377  C CA    . PRO A 1 58  ? 1.61820   3.56366   6.72140   1.000 53.62397  ? 52  PRO A CA    1 ? 
ATOM   378  C C     . PRO A 1 58  ? 1.03973   4.68638   7.57013   1.000 54.40227  ? 52  PRO A C     1 ? 
ATOM   379  O O     . PRO A 1 58  ? -0.14247  4.68051   7.92074   1.000 58.01677  ? 52  PRO A O     1 ? 
ATOM   380  C CB    . PRO A 1 58  ? 0.93368   3.48158   5.35150   1.000 57.12971  ? 52  PRO A CB    1 ? 
ATOM   381  C CG    . PRO A 1 58  ? 0.85765   2.02772   5.05070   1.000 61.35360  ? 52  PRO A CG    1 ? 
ATOM   382  C CD    . PRO A 1 58  ? 0.65202   1.35382   6.37201   1.000 59.01762  ? 52  PRO A CD    1 ? 
ATOM   383  N N     . GLY A 1 59  ? 1.88965   5.65418   7.90147   1.000 55.24610  ? 53  GLY A N     1 ? 
ATOM   384  C CA    . GLY A 1 59  ? 1.46690   6.81996   8.64643   1.000 47.70391  ? 53  GLY A CA    1 ? 
ATOM   385  C C     . GLY A 1 59  ? 1.53180   6.69832   10.15139  1.000 59.26820  ? 53  GLY A C     1 ? 
ATOM   386  O O     . GLY A 1 59  ? 1.02251   7.58678   10.84569  1.000 60.03466  ? 53  GLY A O     1 ? 
ATOM   387  N N     . ALA A 1 60  ? 2.13282   5.63312   10.67953  1.000 54.55346  ? 54  ALA A N     1 ? 
ATOM   388  C CA    . ALA A 1 60  ? 2.26571   5.48427   12.12354  1.000 58.54192  ? 54  ALA A CA    1 ? 
ATOM   389  C C     . ALA A 1 60  ? 3.06197   6.64866   12.69623  1.000 62.02726  ? 54  ALA A C     1 ? 
ATOM   390  O O     . ALA A 1 60  ? 4.20317   6.89225   12.29172  1.000 54.28990  ? 54  ALA A O     1 ? 
ATOM   391  C CB    . ALA A 1 60  ? 2.93864   4.15427   12.45748  1.000 60.10997  ? 54  ALA A CB    1 ? 
ATOM   392  N N     . LEU A 1 61  ? 2.45488   7.37171   13.63404  1.000 60.17369  ? 55  LEU A N     1 ? 
ATOM   393  C CA    . LEU A 1 61  ? 3.03626   8.60515   14.13848  1.000 64.31521  ? 55  LEU A CA    1 ? 
ATOM   394  C C     . LEU A 1 61  ? 2.56246   8.83056   15.56721  1.000 73.38752  ? 55  LEU A C     1 ? 
ATOM   395  O O     . LEU A 1 61  ? 1.45847   8.42591   15.94148  1.000 75.72070  ? 55  LEU A O     1 ? 
ATOM   396  C CB    . LEU A 1 61  ? 2.66101   9.78751   13.23594  1.000 50.48233  ? 55  LEU A CB    1 ? 
ATOM   397  C CG    . LEU A 1 61  ? 3.28925   11.15591  13.48864  1.000 52.18947  ? 55  LEU A CG    1 ? 
ATOM   398  C CD1   . LEU A 1 61  ? 4.75202   11.14360  13.08976  1.000 56.46663  ? 55  LEU A CD1   1 ? 
ATOM   399  C CD2   . LEU A 1 61  ? 2.53874   12.21629  12.70328  1.000 49.25543  ? 55  LEU A CD2   1 ? 
ATOM   400  N N     . SER A 1 62  ? 3.40890   9.48200   16.35976  1.000 70.07316  ? 56  SER A N     1 ? 
ATOM   401  C CA    . SER A 1 62  ? 3.14190   9.65822   17.77925  1.000 72.60962  ? 56  SER A CA    1 ? 
ATOM   402  C C     . SER A 1 62  ? 2.19609   10.82803  18.02786  1.000 72.28491  ? 56  SER A C     1 ? 
ATOM   403  O O     . SER A 1 62  ? 2.19053   11.82208  17.29621  1.000 77.69272  ? 56  SER A O     1 ? 
ATOM   404  C CB    . SER A 1 62  ? 4.44644   9.88531   18.54339  1.000 70.55003  ? 56  SER A CB    1 ? 
ATOM   405  O OG    . SER A 1 62  ? 5.25797   10.84415  17.88703  1.000 64.54712  ? 56  SER A OG    1 ? 
ATOM   406  N N     . ASP A 1 63  ? 1.38800   10.69495  19.08307  1.000 77.32822  ? 57  ASP A N     1 ? 
ATOM   407  C CA    . ASP A 1 63  ? 0.54282   11.79939  19.52408  1.000 83.19977  ? 57  ASP A CA    1 ? 
ATOM   408  C C     . ASP A 1 63  ? 1.37122   12.91210  20.14978  1.000 75.02381  ? 57  ASP A C     1 ? 
ATOM   409  O O     . ASP A 1 63  ? 1.00629   14.08902  20.04979  1.000 84.36172  ? 57  ASP A O     1 ? 
ATOM   410  C CB    . ASP A 1 63  ? -0.49926  11.29308  20.52418  1.000 89.49447  ? 57  ASP A CB    1 ? 
ATOM   411  C CG    . ASP A 1 63  ? -1.88468  11.84156  20.25743  1.000 94.18465  ? 57  ASP A CG    1 ? 
ATOM   412  O OD1   . ASP A 1 63  ? -2.00054  13.05001  19.96964  1.000 97.29155  ? 57  ASP A OD1   1 ? 
ATOM   413  O OD2   . ASP A 1 63  ? -2.85880  11.06387  20.34203  1.000 96.97912  ? 57  ASP A OD2   1 ? 
ATOM   414  N N     . SER A 1 64  ? 2.48150   12.56106  20.79081  1.000 83.06326  ? 58  SER A N     1 ? 
ATOM   415  C CA    . SER A 1 64  ? 3.34128   13.52654  21.45534  1.000 72.55763  ? 58  SER A CA    1 ? 
ATOM   416  C C     . SER A 1 64  ? 4.44344   14.00217  20.51827  1.000 60.65932  ? 58  SER A C     1 ? 
ATOM   417  O O     . SER A 1 64  ? 4.84471   13.29850  19.58718  1.000 49.37275  ? 58  SER A O     1 ? 
ATOM   418  C CB    . SER A 1 64  ? 3.96075   12.91926  22.71465  1.000 64.30154  ? 58  SER A CB    1 ? 
ATOM   419  O OG    . SER A 1 64  ? 5.26006   13.43599  22.94246  1.000 73.38359  ? 58  SER A OG    1 ? 
ATOM   420  N N     . GLU A 1 65  ? 4.93606   15.20856  20.78336  1.000 51.35389  ? 59  GLU A N     1 ? 
ATOM   421  C CA    . GLU A 1 65  ? 5.99176   15.79004  19.97148  1.000 50.55140  ? 59  GLU A CA    1 ? 
ATOM   422  C C     . GLU A 1 65  ? 7.30361   15.03210  20.17121  1.000 63.09233  ? 59  GLU A C     1 ? 
ATOM   423  O O     . GLU A 1 65  ? 7.48509   14.29055  21.14149  1.000 53.99035  ? 59  GLU A O     1 ? 
ATOM   424  C CB    . GLU A 1 65  ? 6.16307   17.27008  20.31126  1.000 57.23091  ? 59  GLU A CB    1 ? 
ATOM   425  C CG    . GLU A 1 65  ? 4.83967   18.00972  20.45206  1.000 63.46380  ? 59  GLU A CG    1 ? 
ATOM   426  C CD    . GLU A 1 65  ? 5.00039   19.51568  20.44536  1.000 66.52358  ? 59  GLU A CD    1 ? 
ATOM   427  O OE1   . GLU A 1 65  ? 6.04854   20.00229  19.97210  1.000 74.07997  ? 59  GLU A OE1   1 ? 
ATOM   428  O OE2   . GLU A 1 65  ? 4.07499   20.21333  20.91147  1.000 73.42366  ? 59  GLU A OE2   1 ? 
ATOM   429  N N     . THR A 1 66  ? 8.22812   15.23310  19.22772  1.000 56.55555  ? 60  THR A N     1 ? 
ATOM   430  C CA    . THR A 1 66  ? 9.45568   14.44064  19.19773  1.000 59.10593  ? 60  THR A CA    1 ? 
ATOM   431  C C     . THR A 1 66  ? 10.30270  14.67086  20.44389  1.000 55.26268  ? 60  THR A C     1 ? 
ATOM   432  O O     . THR A 1 66  ? 10.77957  13.71643  21.06914  1.000 61.09631  ? 60  THR A O     1 ? 
ATOM   433  C CB    . THR A 1 66  ? 10.26131  14.76666  17.93937  1.000 62.35668  ? 60  THR A CB    1 ? 
ATOM   434  O OG1   . THR A 1 66  ? 9.44020   14.57918  16.78127  1.000 52.64044  ? 60  THR A OG1   1 ? 
ATOM   435  C CG2   . THR A 1 66  ? 11.48194  13.86442  17.83887  1.000 55.41904  ? 60  THR A CG2   1 ? 
ATOM   436  N N     . HIS A 1 67  ? 10.50151  15.93451  20.82272  1.000 60.16943  ? 61  HIS A N     1 ? 
ATOM   437  C CA    . HIS A 1 67  ? 11.35941  16.24551  21.96014  1.000 66.55491  ? 61  HIS A CA    1 ? 
ATOM   438  C C     . HIS A 1 67  ? 10.78414  15.77074  23.28834  1.000 66.18161  ? 61  HIS A C     1 ? 
ATOM   439  O O     . HIS A 1 67  ? 11.48781  15.83117  24.30235  1.000 67.14723  ? 61  HIS A O     1 ? 
ATOM   440  C CB    . HIS A 1 67  ? 11.62816  17.75120  22.01937  1.000 57.54339  ? 61  HIS A CB    1 ? 
ATOM   441  C CG    . HIS A 1 67  ? 10.41686  18.57203  22.33447  1.000 59.04704  ? 61  HIS A CG    1 ? 
ATOM   442  N ND1   . HIS A 1 67  ? 9.45595   18.87364  21.39313  1.000 67.74113  ? 61  HIS A ND1   1 ? 
ATOM   443  C CD2   . HIS A 1 67  ? 10.01456  19.16290  23.48443  1.000 60.95291  ? 61  HIS A CD2   1 ? 
ATOM   444  C CE1   . HIS A 1 67  ? 8.51190   19.61010  21.95088  1.000 66.53822  ? 61  HIS A CE1   1 ? 
ATOM   445  N NE2   . HIS A 1 67  ? 8.82685   19.80030  23.21968  1.000 65.03854  ? 61  HIS A NE2   1 ? 
ATOM   446  N N     . LEU A 1 68  ? 9.53658   15.29634  23.30997  1.000 63.79530  ? 62  LEU A N     1 ? 
ATOM   447  C CA    . LEU A 1 68  ? 8.91600   14.80905  24.53260  1.000 62.08060  ? 62  LEU A CA    1 ? 
ATOM   448  C C     . LEU A 1 68  ? 8.61666   13.31813  24.51988  1.000 62.28389  ? 62  LEU A C     1 ? 
ATOM   449  O O     . LEU A 1 68  ? 8.35750   12.75063  25.58538  1.000 58.48339  ? 62  LEU A O     1 ? 
ATOM   450  C CB    . LEU A 1 68  ? 7.61420   15.57517  24.80900  1.000 62.36650  ? 62  LEU A CB    1 ? 
ATOM   451  C CG    . LEU A 1 68  ? 7.79446   17.00730  25.31408  1.000 66.08099  ? 62  LEU A CG    1 ? 
ATOM   452  C CD1   . LEU A 1 68  ? 6.58981   17.44107  26.12166  1.000 69.49428  ? 62  LEU A CD1   1 ? 
ATOM   453  C CD2   . LEU A 1 68  ? 9.05730   17.11715  26.15118  1.000 70.64235  ? 62  LEU A CD2   1 ? 
ATOM   454  N N     . TYR A 1 69  ? 8.64662   12.67416  23.35618  1.000 69.22142  ? 63  TYR A N     1 ? 
ATOM   455  C CA    . TYR A 1 69  ? 8.39068   11.23896  23.25912  1.000 59.02299  ? 63  TYR A CA    1 ? 
ATOM   456  C C     . TYR A 1 69  ? 9.71929   10.48448  23.24745  1.000 58.76908  ? 63  TYR A C     1 ? 
ATOM   457  O O     . TYR A 1 69  ? 10.13575  9.89344   22.24989  1.000 65.26593  ? 63  TYR A O     1 ? 
ATOM   458  C CB    . TYR A 1 69  ? 7.55457   10.93346  22.02014  1.000 62.78171  ? 63  TYR A CB    1 ? 
ATOM   459  C CG    . TYR A 1 69  ? 6.84390   9.60255   22.07966  1.000 67.12793  ? 63  TYR A CG    1 ? 
ATOM   460  C CD1   . TYR A 1 69  ? 5.73644   9.42073   22.89707  1.000 72.64902  ? 63  TYR A CD1   1 ? 
ATOM   461  C CD2   . TYR A 1 69  ? 7.28214   8.52670   21.32105  1.000 61.04328  ? 63  TYR A CD2   1 ? 
ATOM   462  C CE1   . TYR A 1 69  ? 5.08515   8.20420   22.95595  1.000 68.91565  ? 63  TYR A CE1   1 ? 
ATOM   463  C CE2   . TYR A 1 69  ? 6.63838   7.30771   21.37363  1.000 63.94484  ? 63  TYR A CE2   1 ? 
ATOM   464  C CZ    . TYR A 1 69  ? 5.53933   7.15129   22.19072  1.000 68.49327  ? 63  TYR A CZ    1 ? 
ATOM   465  O OH    . TYR A 1 69  ? 4.89505   5.93632   22.24331  1.000 67.94660  ? 63  TYR A OH    1 ? 
ATOM   466  N N     . CYS A 1 70  ? 10.38386  10.51599  24.39792  1.000 66.24776  ? 64  CYS A N     1 ? 
ATOM   467  C CA    . CYS A 1 70  ? 11.69711  9.90293   24.55714  1.000 65.87872  ? 64  CYS A CA    1 ? 
ATOM   468  C C     . CYS A 1 70  ? 11.98709  9.76582   26.04756  1.000 64.74759  ? 64  CYS A C     1 ? 
ATOM   469  O O     . CYS A 1 70  ? 11.12934  10.04694  26.89305  1.000 63.69983  ? 64  CYS A O     1 ? 
ATOM   470  C CB    . CYS A 1 70  ? 12.77075  10.72824  23.84075  1.000 60.24894  ? 64  CYS A CB    1 ? 
ATOM   471  S SG    . CYS A 1 70  ? 12.89651  12.43380  24.42676  1.000 84.52477  ? 64  CYS A SG    1 ? 
ATOM   472  N N     . TYR A 1 71  ? 13.20198  9.33057   26.37220  1.000 62.81790  ? 65  TYR A N     1 ? 
ATOM   473  C CA    . TYR A 1 71  ? 13.64204  9.22164   27.75500  1.000 66.87753  ? 65  TYR A CA    1 ? 
ATOM   474  C C     . TYR A 1 71  ? 14.30340  10.51868  28.19951  1.000 70.60682  ? 65  TYR A C     1 ? 
ATOM   475  O O     . TYR A 1 71  ? 15.00187  11.17243  27.42047  1.000 67.42464  ? 65  TYR A O     1 ? 
ATOM   476  C CB    . TYR A 1 71  ? 14.62289  8.06136   27.93037  1.000 58.00239  ? 65  TYR A CB    1 ? 
ATOM   477  C CG    . TYR A 1 71  ? 14.00671  6.68831   27.79834  1.000 65.10231  ? 65  TYR A CG    1 ? 
ATOM   478  C CD1   . TYR A 1 71  ? 13.09378  6.22157   28.73517  1.000 66.93419  ? 65  TYR A CD1   1 ? 
ATOM   479  C CD2   . TYR A 1 71  ? 14.35260  5.85080   26.74642  1.000 61.73669  ? 65  TYR A CD2   1 ? 
ATOM   480  C CE1   . TYR A 1 71  ? 12.53408  4.96346   28.62146  1.000 59.75170  ? 65  TYR A CE1   1 ? 
ATOM   481  C CE2   . TYR A 1 71  ? 13.79874  4.59160   26.62423  1.000 62.35546  ? 65  TYR A CE2   1 ? 
ATOM   482  C CZ    . TYR A 1 71  ? 12.89051  4.15304   27.56360  1.000 64.08256  ? 65  TYR A CZ    1 ? 
ATOM   483  O OH    . TYR A 1 71  ? 12.33837  2.89888   27.44287  1.000 65.90451  ? 65  TYR A OH    1 ? 
ATOM   484  N N     . SER A 1 72  ? 14.08474  10.88205  29.46324  1.000 73.13236  ? 66  SER A N     1 ? 
ATOM   485  C CA    . SER A 1 72  ? 14.68787  12.07797  30.03480  1.000 75.13162  ? 66  SER A CA    1 ? 
ATOM   486  C C     . SER A 1 72  ? 15.90817  11.78566  30.89509  1.000 73.00232  ? 66  SER A C     1 ? 
ATOM   487  O O     . SER A 1 72  ? 16.71236  12.69440  31.12816  1.000 84.29299  ? 66  SER A O     1 ? 
ATOM   488  C CB    . SER A 1 72  ? 13.66090  12.83955  30.88171  1.000 67.09556  ? 66  SER A CB    1 ? 
ATOM   489  O OG    . SER A 1 72  ? 13.17750  12.03487  31.94297  1.000 64.07421  ? 66  SER A OG    1 ? 
ATOM   490  N N     . TRP A 1 73  ? 16.06860  10.54569  31.36271  1.000 70.85206  ? 67  TRP A N     1 ? 
ATOM   491  C CA    . TRP A 1 73  ? 17.12217  10.24815  32.32725  1.000 72.49933  ? 67  TRP A CA    1 ? 
ATOM   492  C C     . TRP A 1 73  ? 18.50901  10.29254  31.69696  1.000 70.44883  ? 67  TRP A C     1 ? 
ATOM   493  O O     . TRP A 1 73  ? 19.48630  10.61153  32.38364  1.000 79.37243  ? 67  TRP A O     1 ? 
ATOM   494  C CB    . TRP A 1 73  ? 16.86768  8.88586   32.97305  1.000 73.91832  ? 67  TRP A CB    1 ? 
ATOM   495  C CG    . TRP A 1 73  ? 16.67820  7.77563   31.98867  1.000 67.34613  ? 67  TRP A CG    1 ? 
ATOM   496  C CD1   . TRP A 1 73  ? 15.49590  7.32613   31.47742  1.000 65.99898  ? 67  TRP A CD1   1 ? 
ATOM   497  C CD2   . TRP A 1 73  ? 17.70284  6.96355   31.40401  1.000 70.47211  ? 67  TRP A CD2   1 ? 
ATOM   498  N NE1   . TRP A 1 73  ? 15.72146  6.28863   30.60543  1.000 61.80254  ? 67  TRP A NE1   1 ? 
ATOM   499  C CE2   . TRP A 1 73  ? 17.06837  6.04627   30.54313  1.000 65.20277  ? 67  TRP A CE2   1 ? 
ATOM   500  C CE3   . TRP A 1 73  ? 19.09522  6.92453   31.52329  1.000 68.92063  ? 67  TRP A CE3   1 ? 
ATOM   501  C CZ2   . TRP A 1 73  ? 17.77806  5.10161   29.80523  1.000 70.33250  ? 67  TRP A CZ2   1 ? 
ATOM   502  C CZ3   . TRP A 1 73  ? 19.79744  5.98699   30.79045  1.000 69.36229  ? 67  TRP A CZ3   1 ? 
ATOM   503  C CH2   . TRP A 1 73  ? 19.13874  5.08815   29.94229  1.000 73.13651  ? 67  TRP A CH2   1 ? 
ATOM   504  N N     . ASP A 1 74  ? 18.62194  9.98171   30.40779  1.000 67.93595  ? 68  ASP A N     1 ? 
ATOM   505  C CA    . ASP A 1 74  ? 19.90589  10.03547  29.71036  1.000 65.34000  ? 68  ASP A CA    1 ? 
ATOM   506  C C     . ASP A 1 74  ? 20.04843  11.42611  29.10365  1.000 82.73809  ? 68  ASP A C     1 ? 
ATOM   507  O O     . ASP A 1 74  ? 19.51326  11.70682  28.02842  1.000 84.94883  ? 68  ASP A O     1 ? 
ATOM   508  C CB    . ASP A 1 74  ? 19.99479  8.94235   28.65099  1.000 66.38904  ? 68  ASP A CB    1 ? 
ATOM   509  C CG    . ASP A 1 74  ? 21.41503  8.71890   28.15389  1.000 71.69174  ? 68  ASP A CG    1 ? 
ATOM   510  O OD1   . ASP A 1 74  ? 22.20176  9.68824   28.10939  1.000 75.89494  ? 68  ASP A OD1   1 ? 
ATOM   511  O OD2   . ASP A 1 74  ? 21.74613  7.56567   27.80666  1.000 77.50324  ? 68  ASP A OD2   1 ? 
ATOM   512  N N     . LYS A 1 75  ? 20.77602  12.30353  29.79952  1.000 71.08853  ? 69  LYS A N     1 ? 
ATOM   513  C CA    . LYS A 1 75  ? 20.94550  13.66988  29.31734  1.000 68.24303  ? 69  LYS A CA    1 ? 
ATOM   514  C C     . LYS A 1 75  ? 21.82925  13.72639  28.07864  1.000 75.11085  ? 69  LYS A C     1 ? 
ATOM   515  O O     . LYS A 1 75  ? 21.62512  14.58603  27.21361  1.000 82.89006  ? 69  LYS A O     1 ? 
ATOM   516  C CB    . LYS A 1 75  ? 21.52435  14.54969  30.42469  1.000 69.83298  ? 69  LYS A CB    1 ? 
ATOM   517  C CG    . LYS A 1 75  ? 20.68184  14.58269  31.68905  1.000 79.58663  ? 69  LYS A CG    1 ? 
ATOM   518  C CD    . LYS A 1 75  ? 19.52696  15.56144  31.55408  1.000 92.49568  ? 69  LYS A CD    1 ? 
ATOM   519  C CE    . LYS A 1 75  ? 18.36748  15.17550  32.45808  1.000 92.74426  ? 69  LYS A CE    1 ? 
ATOM   520  N NZ    . LYS A 1 75  ? 17.05206  15.53009  31.85500  1.000 88.96229  ? 69  LYS A NZ    1 ? 
ATOM   521  N N     . GLU A 1 76  ? 22.81296  12.82957  27.97548  1.000 76.79383  ? 70  GLU A N     1 ? 
ATOM   522  C CA    . GLU A 1 76  ? 23.64876  12.78995  26.78078  1.000 85.05751  ? 70  GLU A CA    1 ? 
ATOM   523  C C     . GLU A 1 76  ? 22.84605  12.38559  25.55207  1.000 92.68456  ? 70  GLU A C     1 ? 
ATOM   524  O O     . GLU A 1 76  ? 23.12559  12.86165  24.44611  1.000 98.35211  ? 70  GLU A O     1 ? 
ATOM   525  C CB    . GLU A 1 76  ? 24.82071  11.83083  26.98999  1.000 89.87717  ? 70  GLU A CB    1 ? 
ATOM   526  C CG    . GLU A 1 76  ? 26.00914  12.44124  27.71979  1.000 95.53387  ? 70  GLU A CG    1 ? 
ATOM   527  C CD    . GLU A 1 76  ? 25.83555  12.45195  29.22847  1.000 107.83151 ? 70  GLU A CD    1 ? 
ATOM   528  O OE1   . GLU A 1 76  ? 24.86866  13.07337  29.71838  1.000 93.49762  ? 70  GLU A OE1   1 ? 
ATOM   529  O OE2   . GLU A 1 76  ? 26.66905  11.83662  29.92662  1.000 120.82776 ? 70  GLU A OE2   1 ? 
ATOM   530  N N     . LEU A 1 77  ? 21.84776  11.51655  25.72628  1.000 93.23186  ? 71  LEU A N     1 ? 
ATOM   531  C CA    . LEU A 1 77  ? 21.00151  11.12024  24.60574  1.000 79.12380  ? 71  LEU A CA    1 ? 
ATOM   532  C C     . LEU A 1 77  ? 20.14253  12.28239  24.12350  1.000 75.28919  ? 71  LEU A C     1 ? 
ATOM   533  O O     . LEU A 1 77  ? 19.93182  12.44629  22.91620  1.000 80.20507  ? 71  LEU A O     1 ? 
ATOM   534  C CB    . LEU A 1 77  ? 20.12251  9.93702   25.01029  1.000 75.13289  ? 71  LEU A CB    1 ? 
ATOM   535  C CG    . LEU A 1 77  ? 19.91668  8.81927   23.98666  1.000 76.17434  ? 71  LEU A CG    1 ? 
ATOM   536  C CD1   . LEU A 1 77  ? 21.14831  8.64220   23.11171  1.000 87.61749  ? 71  LEU A CD1   1 ? 
ATOM   537  C CD2   . LEU A 1 77  ? 19.56747  7.52086   24.69400  1.000 81.27499  ? 71  LEU A CD2   1 ? 
ATOM   538  N N     . LEU A 1 78  ? 19.63898  13.09851  25.05331  1.000 72.69851  ? 72  LEU A N     1 ? 
ATOM   539  C CA    . LEU A 1 78  ? 18.79186  14.22593  24.67636  1.000 75.80609  ? 72  LEU A CA    1 ? 
ATOM   540  C C     . LEU A 1 78  ? 19.55775  15.24071  23.83651  1.000 82.85473  ? 72  LEU A C     1 ? 
ATOM   541  O O     . LEU A 1 78  ? 19.03422  15.75544  22.84133  1.000 78.41833  ? 72  LEU A O     1 ? 
ATOM   542  C CB    . LEU A 1 78  ? 18.21866  14.88757  25.92902  1.000 74.60049  ? 72  LEU A CB    1 ? 
ATOM   543  C CG    . LEU A 1 78  ? 17.22549  14.04403  26.72827  1.000 74.45576  ? 72  LEU A CG    1 ? 
ATOM   544  C CD1   . LEU A 1 78  ? 16.86423  14.73022  28.03551  1.000 71.81273  ? 72  LEU A CD1   1 ? 
ATOM   545  C CD2   . LEU A 1 78  ? 15.98072  13.78446  25.89738  1.000 80.04441  ? 72  LEU A CD2   1 ? 
ATOM   546  N N     . GLN A 1 79  ? 20.79948  15.54372  24.22240  1.000 82.09045  ? 73  GLN A N     1 ? 
ATOM   547  C CA    . GLN A 1 79  ? 21.61013  16.46945  23.43836  1.000 78.66408  ? 73  GLN A CA    1 ? 
ATOM   548  C C     . GLN A 1 79  ? 22.04428  15.84934  22.11620  1.000 79.22923  ? 73  GLN A C     1 ? 
ATOM   549  O O     . GLN A 1 79  ? 22.31292  16.57173  21.14960  1.000 77.56089  ? 73  GLN A O     1 ? 
ATOM   550  C CB    . GLN A 1 79  ? 22.83046  16.90829  24.24820  1.000 79.89065  ? 73  GLN A CB    1 ? 
ATOM   551  C CG    . GLN A 1 79  ? 23.26680  18.34312  24.00224  1.000 84.59703  ? 73  GLN A CG    1 ? 
ATOM   552  C CD    . GLN A 1 79  ? 22.24378  19.35831  24.47691  1.000 82.93679  ? 73  GLN A CD    1 ? 
ATOM   553  O OE1   . GLN A 1 79  ? 21.41836  19.06964  25.34420  1.000 74.33064  ? 73  GLN A OE1   1 ? 
ATOM   554  N NE2   . GLN A 1 79  ? 22.29813  20.55887  23.91216  1.000 88.87923  ? 73  GLN A NE2   1 ? 
ATOM   555  N N     . GLU A 1 80  ? 22.11534  14.52186  22.05734  1.000 80.23525  ? 74  GLU A N     1 ? 
ATOM   556  C CA    . GLU A 1 80  ? 22.50098  13.78831  20.86029  1.000 78.39756  ? 74  GLU A CA    1 ? 
ATOM   557  C C     . GLU A 1 80  ? 21.30694  13.44790  19.97365  1.000 79.42266  ? 74  GLU A C     1 ? 
ATOM   558  O O     . GLU A 1 80  ? 21.49647  13.08197  18.80762  1.000 74.43775  ? 74  GLU A O     1 ? 
ATOM   559  C CB    . GLU A 1 80  ? 23.24585  12.51057  21.28246  1.000 76.59712  ? 74  GLU A CB    1 ? 
ATOM   560  C CG    . GLU A 1 80  ? 23.66384  11.55505  20.17755  1.000 92.37839  ? 74  GLU A CG    1 ? 
ATOM   561  C CD    . GLU A 1 80  ? 24.44787  10.37069  20.71315  1.000 103.77261 ? 74  GLU A CD    1 ? 
ATOM   562  O OE1   . GLU A 1 80  ? 25.33533  10.58131  21.56749  1.000 96.87254  ? 74  GLU A OE1   1 ? 
ATOM   563  O OE2   . GLU A 1 80  ? 24.17265  9.22918   20.28690  1.000 101.26106 ? 74  GLU A OE2   1 ? 
ATOM   564  N N     . MET A 1 81  ? 20.08928  13.60652  20.48600  1.000 75.37314  ? 75  MET A N     1 ? 
ATOM   565  C CA    . MET A 1 81  ? 18.89683  13.12100  19.80467  1.000 83.65894  ? 75  MET A CA    1 ? 
ATOM   566  C C     . MET A 1 81  ? 18.65061  13.85533  18.49205  1.000 74.69956  ? 75  MET A C     1 ? 
ATOM   567  O O     . MET A 1 81  ? 18.81415  15.07534  18.39937  1.000 76.25504  ? 75  MET A O     1 ? 
ATOM   568  C CB    . MET A 1 81  ? 17.68053  13.28077  20.71399  1.000 75.15051  ? 75  MET A CB    1 ? 
ATOM   569  C CG    . MET A 1 81  ? 16.85865  12.02274  20.89312  1.000 77.03465  ? 75  MET A CG    1 ? 
ATOM   570  S SD    . MET A 1 81  ? 15.49131  12.28797  22.03517  1.000 84.34807  ? 75  MET A SD    1 ? 
ATOM   571  C CE    . MET A 1 81  ? 14.31078  13.10650  20.96606  1.000 68.96292  ? 75  MET A CE    1 ? 
ATOM   572  N N     . GLU A 1 82  ? 18.24446  13.09739  17.47505  1.000 67.02139  ? 76  GLU A N     1 ? 
ATOM   573  C CA    . GLU A 1 82  ? 17.77533  13.67952  16.22606  1.000 73.57953  ? 76  GLU A CA    1 ? 
ATOM   574  C C     . GLU A 1 82  ? 16.35243  14.19099  16.40324  1.000 71.35093  ? 76  GLU A C     1 ? 
ATOM   575  O O     . GLU A 1 82  ? 15.47977  13.46464  16.88945  1.000 69.92397  ? 76  GLU A O     1 ? 
ATOM   576  C CB    . GLU A 1 82  ? 17.81300  12.64935  15.09692  1.000 75.50403  ? 76  GLU A CB    1 ? 
ATOM   577  C CG    . GLU A 1 82  ? 19.17873  12.06377  14.79096  1.000 100.62334 ? 76  GLU A CG    1 ? 
ATOM   578  C CD    . GLU A 1 82  ? 19.19261  11.30089  13.47754  1.000 103.48650 ? 76  GLU A CD    1 ? 
ATOM   579  O OE1   . GLU A 1 82  ? 18.11981  11.18139  12.84796  1.000 88.37359  ? 76  GLU A OE1   1 ? 
ATOM   580  O OE2   . GLU A 1 82  ? 20.27274  10.81962  13.07501  1.000 103.36313 ? 76  GLU A OE2   1 ? 
ATOM   581  N N     . ILE A 1 83  ? 16.11927  15.44215  16.01328  1.000 66.44017  ? 77  ILE A N     1 ? 
ATOM   582  C CA    . ILE A 1 83  ? 14.76744  15.98726  15.97785  1.000 67.34000  ? 77  ILE A CA    1 ? 
ATOM   583  C C     . ILE A 1 83  ? 14.50907  16.48323  14.56129  1.000 60.64592  ? 77  ILE A C     1 ? 
ATOM   584  O O     . ILE A 1 83  ? 14.71920  17.66105  14.24873  1.000 63.79595  ? 77  ILE A O     1 ? 
ATOM   585  C CB    . ILE A 1 83  ? 14.57230  17.10068  17.02424  1.000 62.33453  ? 77  ILE A CB    1 ? 
ATOM   586  C CG1   . ILE A 1 83  ? 14.75537  16.53734  18.43375  1.000 56.41451  ? 77  ILE A CG1   1 ? 
ATOM   587  C CG2   . ILE A 1 83  ? 13.17971  17.70410  16.91616  1.000 63.71330  ? 77  ILE A CG2   1 ? 
ATOM   588  C CD1   . ILE A 1 83  ? 14.63491  17.57601  19.52587  1.000 56.08480  ? 77  ILE A CD1   1 ? 
ATOM   589  N N     . LYS A 1 84  ? 14.07646  15.57434  13.68634  1.000 52.88326  ? 78  LYS A N     1 ? 
ATOM   590  C CA    . LYS A 1 84  ? 13.86838  15.93085  12.28826  1.000 64.00135  ? 78  LYS A CA    1 ? 
ATOM   591  C C     . LYS A 1 84  ? 12.56080  16.68643  12.09004  1.000 68.52026  ? 78  LYS A C     1 ? 
ATOM   592  O O     . LYS A 1 84  ? 12.52504  17.68808  11.36681  1.000 67.94198  ? 78  LYS A O     1 ? 
ATOM   593  C CB    . LYS A 1 84  ? 13.89802  14.67454  11.41623  1.000 64.03810  ? 78  LYS A CB    1 ? 
ATOM   594  C CG    . LYS A 1 84  ? 15.29301  14.10330  11.19926  1.000 73.75178  ? 78  LYS A CG    1 ? 
ATOM   595  C CD    . LYS A 1 84  ? 15.29324  12.95074  10.20072  1.000 74.78592  ? 78  LYS A CD    1 ? 
ATOM   596  C CE    . LYS A 1 84  ? 13.99685  12.15706  10.24698  1.000 63.32231  ? 78  LYS A CE    1 ? 
ATOM   597  N NZ    . LYS A 1 84  ? 14.02039  11.00627  9.30295   1.000 88.41863  ? 78  LYS A NZ    1 ? 
ATOM   598  N N     . ARG A 1 85  ? 11.48230  16.22955  12.72287  1.000 58.50501  ? 79  ARG A N     1 ? 
ATOM   599  C CA    . ARG A 1 85  ? 10.17680  16.85062  12.56495  1.000 63.02298  ? 79  ARG A CA    1 ? 
ATOM   600  C C     . ARG A 1 85  ? 9.52059   17.00215  13.92960  1.000 58.79657  ? 79  ARG A C     1 ? 
ATOM   601  O O     . ARG A 1 85  ? 9.99464   16.46946  14.93693  1.000 57.12834  ? 79  ARG A O     1 ? 
ATOM   602  C CB    . ARG A 1 85  ? 9.28598   16.04448  11.61256  1.000 58.08230  ? 79  ARG A CB    1 ? 
ATOM   603  C CG    . ARG A 1 85  ? 9.65011   16.22568  10.14894  1.000 54.00600  ? 79  ARG A CG    1 ? 
ATOM   604  C CD    . ARG A 1 85  ? 8.67559   15.50544  9.23669   1.000 74.50614  ? 79  ARG A CD    1 ? 
ATOM   605  N NE    . ARG A 1 85  ? 9.32455   14.43125  8.49514   1.000 72.02493  ? 79  ARG A NE    1 ? 
ATOM   606  C CZ    . ARG A 1 85  ? 9.57750   13.22682  8.98860   1.000 86.90850  ? 79  ARG A CZ    1 ? 
ATOM   607  N NH1   . ARG A 1 85  ? 9.24233   12.90251  10.22675  1.000 79.86757  ? 79  ARG A NH1   1 ? 
ATOM   608  N NH2   . ARG A 1 85  ? 10.18101  12.32451  8.22014   1.000 93.06063  ? 79  ARG A NH2   1 ? 
ATOM   609  N N     . LYS A 1 86  ? 8.41644   17.75437  13.94836  1.000 62.41431  ? 80  LYS A N     1 ? 
ATOM   610  C CA    . LYS A 1 86  ? 7.74292   18.06816  15.20512  1.000 61.11342  ? 80  LYS A CA    1 ? 
ATOM   611  C C     . LYS A 1 86  ? 7.26546   16.80427  15.90920  1.000 62.18190  ? 80  LYS A C     1 ? 
ATOM   612  O O     . LYS A 1 86  ? 7.31638   16.71356  17.14147  1.000 59.19941  ? 80  LYS A O     1 ? 
ATOM   613  C CB    . LYS A 1 86  ? 6.57375   19.01727  14.94131  1.000 62.08238  ? 80  LYS A CB    1 ? 
ATOM   614  C CG    . LYS A 1 86  ? 6.06567   19.74999  16.16976  1.000 57.88839  ? 80  LYS A CG    1 ? 
ATOM   615  C CD    . LYS A 1 86  ? 5.86475   21.22912  15.87204  1.000 63.40265  ? 80  LYS A CD    1 ? 
ATOM   616  C CE    . LYS A 1 86  ? 4.66888   21.79388  16.62121  1.000 74.24534  ? 80  LYS A CE    1 ? 
ATOM   617  N NZ    . LYS A 1 86  ? 5.05161   22.39481  17.92721  1.000 106.56729 ? 80  LYS A NZ    1 ? 
ATOM   618  N N     . TYR A 1 87  ? 6.80225   15.81934  15.14502  1.000 59.15038  ? 81  TYR A N     1 ? 
ATOM   619  C CA    . TYR A 1 87  ? 6.40636   14.52473  15.67520  1.000 54.23193  ? 81  TYR A CA    1 ? 
ATOM   620  C C     . TYR A 1 87  ? 7.23658   13.43822  15.00714  1.000 48.78787  ? 81  TYR A C     1 ? 
ATOM   621  O O     . TYR A 1 87  ? 7.64965   13.57201  13.85116  1.000 58.77949  ? 81  TYR A O     1 ? 
ATOM   622  C CB    . TYR A 1 87  ? 4.90772   14.26590  15.46690  1.000 60.26975  ? 81  TYR A CB    1 ? 
ATOM   623  C CG    . TYR A 1 87  ? 4.02470   15.31002  16.11410  1.000 53.18966  ? 81  TYR A CG    1 ? 
ATOM   624  C CD1   . TYR A 1 87  ? 3.80161   16.53609  15.50134  1.000 55.13259  ? 81  TYR A CD1   1 ? 
ATOM   625  C CD2   . TYR A 1 87  ? 3.42580   15.07510  17.34501  1.000 49.65133  ? 81  TYR A CD2   1 ? 
ATOM   626  C CE1   . TYR A 1 87  ? 3.00365   17.49454  16.09173  1.000 57.74278  ? 81  TYR A CE1   1 ? 
ATOM   627  C CE2   . TYR A 1 87  ? 2.62360   16.02930  17.94339  1.000 62.33258  ? 81  TYR A CE2   1 ? 
ATOM   628  C CZ    . TYR A 1 87  ? 2.41563   17.23703  17.31126  1.000 65.13862  ? 81  TYR A CZ    1 ? 
ATOM   629  O OH    . TYR A 1 87  ? 1.61835   18.19173  17.90031  1.000 73.06001  ? 81  TYR A OH    1 ? 
ATOM   630  N N     . ILE A 1 88  ? 7.48499   12.36279  15.74741  1.000 50.98940  ? 82  ILE A N     1 ? 
ATOM   631  C CA    . ILE A 1 88  ? 8.43393   11.33266  15.34358  1.000 58.33024  ? 82  ILE A CA    1 ? 
ATOM   632  C C     . ILE A 1 88  ? 7.67259   10.15462  14.74898  1.000 59.92647  ? 82  ILE A C     1 ? 
ATOM   633  O O     . ILE A 1 88  ? 6.67095   9.69722   15.31486  1.000 65.83826  ? 82  ILE A O     1 ? 
ATOM   634  C CB    . ILE A 1 88  ? 9.31572   10.90088  16.53002  1.000 54.46630  ? 82  ILE A CB    1 ? 
ATOM   635  C CG1   . ILE A 1 88  ? 10.31392  9.82762   16.09855  1.000 47.07722  ? 82  ILE A CG1   1 ? 
ATOM   636  C CG2   . ILE A 1 88  ? 8.46761   10.44507  17.71460  1.000 54.73607  ? 82  ILE A CG2   1 ? 
ATOM   637  C CD1   . ILE A 1 88  ? 11.38147  9.53597   17.12686  1.000 44.01452  ? 82  ILE A CD1   1 ? 
ATOM   638  N N     . SER A 1 89  ? 8.13615   9.67592   13.59713  1.000 55.46772  ? 83  SER A N     1 ? 
ATOM   639  C CA    . SER A 1 89  ? 7.49367   8.56326   12.91736  1.000 55.06139  ? 83  SER A CA    1 ? 
ATOM   640  C C     . SER A 1 89  ? 7.94365   7.23444   13.51684  1.000 58.13248  ? 83  SER A C     1 ? 
ATOM   641  O O     . SER A 1 89  ? 8.92326   7.15828   14.26211  1.000 61.10250  ? 83  SER A O     1 ? 
ATOM   642  C CB    . SER A 1 89  ? 7.80356   8.59488   11.42013  1.000 49.21900  ? 83  SER A CB    1 ? 
ATOM   643  O OG    . SER A 1 89  ? 7.33337   9.79238   10.82619  1.000 71.85830  ? 83  SER A OG    1 ? 
ATOM   644  N N     . GLN A 1 90  ? 7.20845   6.17623   13.17265  1.000 64.14688  ? 84  GLN A N     1 ? 
ATOM   645  C CA    . GLN A 1 90  ? 7.51714   4.84931   13.70529  1.000 65.37390  ? 84  GLN A CA    1 ? 
ATOM   646  C C     . GLN A 1 90  ? 8.94476   4.40093   13.42328  1.000 58.27751  ? 84  GLN A C     1 ? 
ATOM   647  O O     . GLN A 1 90  ? 9.59942   3.89678   14.35451  1.000 53.21459  ? 84  GLN A O     1 ? 
ATOM   648  C CB    . GLN A 1 90  ? 6.50569   3.82865   13.17375  1.000 61.72805  ? 84  GLN A CB    1 ? 
ATOM   649  C CG    . GLN A 1 90  ? 6.78002   2.40557   13.63392  1.000 52.64567  ? 84  GLN A CG    1 ? 
ATOM   650  C CD    . GLN A 1 90  ? 7.55552   1.59703   12.61131  1.000 57.22760  ? 84  GLN A CD    1 ? 
ATOM   651  O OE1   . GLN A 1 90  ? 7.61931   1.95823   11.43653  1.000 63.60302  ? 84  GLN A OE1   1 ? 
ATOM   652  N NE2   . GLN A 1 90  ? 8.15048   0.49588   13.05495  1.000 60.12293  ? 84  GLN A NE2   1 ? 
ATOM   653  N N     . PRO A 1 91  ? 9.49063   4.52325   12.20384  1.000 60.90679  ? 85  PRO A N     1 ? 
ATOM   654  C CA    . PRO A 1 91  ? 10.88238  4.08152   12.00569  1.000 55.48683  ? 85  PRO A CA    1 ? 
ATOM   655  C C     . PRO A 1 91  ? 11.87639  4.84362   12.86282  1.000 64.77635  ? 85  PRO A C     1 ? 
ATOM   656  O O     . PRO A 1 91  ? 12.85098  4.25523   13.34782  1.000 65.20367  ? 85  PRO A O     1 ? 
ATOM   657  C CB    . PRO A 1 91  ? 11.12786  4.31566   10.50712  1.000 59.30512  ? 85  PRO A CB    1 ? 
ATOM   658  C CG    . PRO A 1 91  ? 9.79109   4.47671   9.89378   1.000 57.00313  ? 85  PRO A CG    1 ? 
ATOM   659  C CD    . PRO A 1 91  ? 8.88248   5.00493   10.94837  1.000 55.61576  ? 85  PRO A CD    1 ? 
ATOM   660  N N     . ASP A 1 92  ? 11.64985  6.14161   13.07435  1.000 66.01754  ? 86  ASP A N     1 ? 
ATOM   661  C CA    . ASP A 1 92  ? 12.57206  6.92254   13.88979  1.000 70.37767  ? 86  ASP A CA    1 ? 
ATOM   662  C C     . ASP A 1 92  ? 12.45073  6.57441   15.36941  1.000 62.22591  ? 86  ASP A C     1 ? 
ATOM   663  O O     . ASP A 1 92  ? 13.43406  6.68679   16.11020  1.000 55.81264  ? 86  ASP A O     1 ? 
ATOM   664  C CB    . ASP A 1 92  ? 12.33358  8.41516   13.66454  1.000 58.35962  ? 86  ASP A CB    1 ? 
ATOM   665  C CG    . ASP A 1 92  ? 12.49505  8.81948   12.21149  1.000 70.21541  ? 86  ASP A CG    1 ? 
ATOM   666  O OD1   . ASP A 1 92  ? 13.35295  8.23038   11.52054  1.000 77.87219  ? 86  ASP A OD1   1 ? 
ATOM   667  O OD2   . ASP A 1 92  ? 11.76238  9.72548   11.75965  1.000 79.31713  ? 86  ASP A OD2   1 ? 
ATOM   668  N N     . VAL A 1 93  ? 11.26568  6.15376   15.82023  1.000 58.80802  ? 87  VAL A N     1 ? 
ATOM   669  C CA    . VAL A 1 93  ? 11.12175  5.70300   17.20239  1.000 53.02135  ? 87  VAL A CA    1 ? 
ATOM   670  C C     . VAL A 1 93  ? 11.88321  4.40141   17.41215  1.000 61.87711  ? 87  VAL A C     1 ? 
ATOM   671  O O     . VAL A 1 93  ? 12.58962  4.22856   18.41262  1.000 64.62137  ? 87  VAL A O     1 ? 
ATOM   672  C CB    . VAL A 1 93  ? 9.63696   5.54253   17.57676  1.000 52.05989  ? 87  VAL A CB    1 ? 
ATOM   673  C CG1   . VAL A 1 93  ? 9.51303   5.02827   19.00210  1.000 55.19937  ? 87  VAL A CG1   1 ? 
ATOM   674  C CG2   . VAL A 1 93  ? 8.89355   6.85154   17.42355  1.000 57.94710  ? 87  VAL A CG2   1 ? 
ATOM   675  N N     . LEU A 1 94  ? 11.74403  3.46392   16.47084  1.000 58.32019  ? 88  LEU A N     1 ? 
ATOM   676  C CA    . LEU A 1 94  ? 12.46069  2.19741   16.57074  1.000 59.81947  ? 88  LEU A CA    1 ? 
ATOM   677  C C     . LEU A 1 94  ? 13.96724  2.41702   16.55883  1.000 60.16244  ? 88  LEU A C     1 ? 
ATOM   678  O O     . LEU A 1 94  ? 14.70668  1.73910   17.28139  1.000 57.60848  ? 88  LEU A O     1 ? 
ATOM   679  C CB    . LEU A 1 94  ? 12.04370  1.26886   15.43004  1.000 51.67616  ? 88  LEU A CB    1 ? 
ATOM   680  C CG    . LEU A 1 94  ? 12.36570  -0.21510  15.61411  1.000 61.50430  ? 88  LEU A CG    1 ? 
ATOM   681  C CD1   . LEU A 1 94  ? 11.77458  -0.72907  16.91595  1.000 52.02225  ? 88  LEU A CD1   1 ? 
ATOM   682  C CD2   . LEU A 1 94  ? 11.85860  -1.02786  14.43304  1.000 49.62960  ? 88  LEU A CD2   1 ? 
ATOM   683  N N     . ALA A 1 95  ? 14.43966  3.36625   15.74744  1.000 57.84625  ? 89  ALA A N     1 ? 
ATOM   684  C CA    . ALA A 1 95  ? 15.86665  3.66635   15.71297  1.000 56.68401  ? 89  ALA A CA    1 ? 
ATOM   685  C C     . ALA A 1 95  ? 16.33545  4.26854   17.03104  1.000 68.06413  ? 89  ALA A C     1 ? 
ATOM   686  O O     . ALA A 1 95  ? 17.43062  3.95119   17.50998  1.000 76.45575  ? 89  ALA A O     1 ? 
ATOM   687  C CB    . ALA A 1 95  ? 16.17754  4.60776   14.55007  1.000 44.16984  ? 89  ALA A CB    1 ? 
ATOM   688  N N     . TYR A 1 96  ? 15.52038  5.13838   17.63195  1.000 60.68267  ? 90  TYR A N     1 ? 
ATOM   689  C CA    . TYR A 1 96  ? 15.88130  5.72541   18.91840  1.000 64.23430  ? 90  TYR A CA    1 ? 
ATOM   690  C C     . TYR A 1 96  ? 15.93154  4.66140   20.00787  1.000 65.38856  ? 90  TYR A C     1 ? 
ATOM   691  O O     . TYR A 1 96  ? 16.86718  4.62536   20.81522  1.000 57.66205  ? 90  TYR A O     1 ? 
ATOM   692  C CB    . TYR A 1 96  ? 14.89152  6.83249   19.28472  1.000 49.07712  ? 90  TYR A CB    1 ? 
ATOM   693  C CG    . TYR A 1 96  ? 14.91788  7.22803   20.74512  1.000 60.86854  ? 90  TYR A CG    1 ? 
ATOM   694  C CD1   . TYR A 1 96  ? 15.88099  8.10367   21.22911  1.000 62.65115  ? 90  TYR A CD1   1 ? 
ATOM   695  C CD2   . TYR A 1 96  ? 13.97374  6.73419   21.63758  1.000 61.27216  ? 90  TYR A CD2   1 ? 
ATOM   696  C CE1   . TYR A 1 96  ? 15.90899  8.47012   22.56102  1.000 62.59968  ? 90  TYR A CE1   1 ? 
ATOM   697  C CE2   . TYR A 1 96  ? 13.99425  7.09461   22.97155  1.000 62.80490  ? 90  TYR A CE2   1 ? 
ATOM   698  C CZ    . TYR A 1 96  ? 14.96356  7.96305   23.42705  1.000 66.92764  ? 90  TYR A CZ    1 ? 
ATOM   699  O OH    . TYR A 1 96  ? 14.98812  8.32688   24.75305  1.000 66.14859  ? 90  TYR A OH    1 ? 
ATOM   700  N N     . LEU A 1 97  ? 14.92674  3.78227   20.04580  1.000 65.04480  ? 91  LEU A N     1 ? 
ATOM   701  C CA    . LEU A 1 97  ? 14.92776  2.70599   21.03022  1.000 60.64950  ? 91  LEU A CA    1 ? 
ATOM   702  C C     . LEU A 1 97  ? 16.02545  1.68934   20.74533  1.000 65.60347  ? 91  LEU A C     1 ? 
ATOM   703  O O     . LEU A 1 97  ? 16.54586  1.06511   21.67694  1.000 67.80724  ? 91  LEU A O     1 ? 
ATOM   704  C CB    . LEU A 1 97  ? 13.55938  2.02599   21.06697  1.000 54.85741  ? 91  LEU A CB    1 ? 
ATOM   705  C CG    . LEU A 1 97  ? 12.45775  2.80675   21.78792  1.000 58.69769  ? 91  LEU A CG    1 ? 
ATOM   706  C CD1   . LEU A 1 97  ? 11.11537  2.10516   21.65147  1.000 63.13776  ? 91  LEU A CD1   1 ? 
ATOM   707  C CD2   . LEU A 1 97  ? 12.81400  3.01076   23.25335  1.000 54.95303  ? 91  LEU A CD2   1 ? 
ATOM   708  N N     . LYS A 1 98  ? 16.38741  1.50719   19.47257  1.000 62.83588  ? 92  LYS A N     1 ? 
ATOM   709  C CA    . LYS A 1 98  ? 17.54145  0.67574   19.14596  1.000 63.34678  ? 92  LYS A CA    1 ? 
ATOM   710  C C     . LYS A 1 98  ? 18.82926  1.30485   19.66061  1.000 67.81566  ? 92  LYS A C     1 ? 
ATOM   711  O O     . LYS A 1 98  ? 19.70914  0.60349   20.17334  1.000 82.28359  ? 92  LYS A O     1 ? 
ATOM   712  C CB    . LYS A 1 98  ? 17.62412  0.45687   17.63551  1.000 68.79295  ? 92  LYS A CB    1 ? 
ATOM   713  C CG    . LYS A 1 98  ? 16.81883  -0.72275  17.11800  1.000 72.27748  ? 92  LYS A CG    1 ? 
ATOM   714  C CD    . LYS A 1 98  ? 16.93220  -0.82730  15.60449  1.000 71.76227  ? 92  LYS A CD    1 ? 
ATOM   715  C CE    . LYS A 1 98  ? 16.13331  -1.99947  15.06248  1.000 74.30944  ? 92  LYS A CE    1 ? 
ATOM   716  N NZ    . LYS A 1 98  ? 16.66666  -2.47106  13.75461  1.000 87.63316  ? 92  LYS A NZ    1 ? 
ATOM   717  N N     . ARG A 1 99  ? 18.95615  2.62784   19.52824  1.000 65.42254  ? 93  ARG A N     1 ? 
ATOM   718  C CA    . ARG A 1 99  ? 20.13138  3.32199   20.04399  1.000 72.43986  ? 93  ARG A CA    1 ? 
ATOM   719  C C     . ARG A 1 99  ? 20.18774  3.24907   21.56565  1.000 76.27670  ? 93  ARG A C     1 ? 
ATOM   720  O O     . ARG A 1 99  ? 21.27361  3.14033   22.14789  1.000 77.33567  ? 93  ARG A O     1 ? 
ATOM   721  C CB    . ARG A 1 99  ? 20.12546  4.77484   19.56211  1.000 59.91241  ? 93  ARG A CB    1 ? 
ATOM   722  C CG    . ARG A 1 99  ? 21.12538  5.69407   20.25260  1.000 75.07292  ? 93  ARG A CG    1 ? 
ATOM   723  C CD    . ARG A 1 99  ? 22.55639  5.19587   20.11297  1.000 84.39003  ? 93  ARG A CD    1 ? 
ATOM   724  N NE    . ARG A 1 99  ? 23.51157  6.12972   20.69742  1.000 89.61281  ? 93  ARG A NE    1 ? 
ATOM   725  C CZ    . ARG A 1 99  ? 24.81081  5.89554   20.82138  1.000 85.99944  ? 93  ARG A CZ    1 ? 
ATOM   726  N NH1   . ARG A 1 99  ? 25.34947  4.75581   20.41987  1.000 85.25078  ? 93  ARG A NH1   1 ? 
ATOM   727  N NH2   . ARG A 1 99  ? 25.58835  6.82613   21.36753  1.000 90.48621  ? 93  ARG A NH2   1 ? 
ATOM   728  N N     . VAL A 1 100 ? 19.02821  3.30066   22.22594  1.000 65.42531  ? 94  VAL A N     1 ? 
ATOM   729  C CA    . VAL A 1 100 ? 18.99294  3.14798   23.67799  1.000 66.74036  ? 94  VAL A CA    1 ? 
ATOM   730  C C     . VAL A 1 100 ? 19.53221  1.78062   24.07842  1.000 76.22318  ? 94  VAL A C     1 ? 
ATOM   731  O O     . VAL A 1 100 ? 20.30370  1.65544   25.03783  1.000 77.93238  ? 94  VAL A O     1 ? 
ATOM   732  C CB    . VAL A 1 100 ? 17.56237  3.37203   24.20441  1.000 67.39074  ? 94  VAL A CB    1 ? 
ATOM   733  C CG1   . VAL A 1 100 ? 17.44423  2.91171   25.65035  1.000 71.23204  ? 94  VAL A CG1   1 ? 
ATOM   734  C CG2   . VAL A 1 100 ? 17.16887  4.83499   24.07248  1.000 68.82199  ? 94  VAL A CG2   1 ? 
ATOM   735  N N     . ALA A 1 101 ? 19.14715  0.73630   23.34082  1.000 75.76398  ? 95  ALA A N     1 ? 
ATOM   736  C CA    . ALA A 1 101 ? 19.65154  -0.60166  23.63089  1.000 78.81889  ? 95  ALA A CA    1 ? 
ATOM   737  C C     . ALA A 1 101 ? 21.13677  -0.71561  23.30874  1.000 85.03750  ? 95  ALA A C     1 ? 
ATOM   738  O O     . ALA A 1 101 ? 21.88064  -1.40235  24.01908  1.000 86.50906  ? 95  ALA A O     1 ? 
ATOM   739  C CB    . ALA A 1 101 ? 18.84961  -1.64392  22.85185  1.000 74.21663  ? 95  ALA A CB    1 ? 
ATOM   740  N N     . ASP A 1 102 ? 21.58588  -0.04905  22.24321  1.000 82.19353  ? 96  ASP A N     1 ? 
ATOM   741  C CA    . ASP A 1 102 ? 22.99626  -0.09438  21.86840  1.000 79.14660  ? 96  ASP A CA    1 ? 
ATOM   742  C C     . ASP A 1 102 ? 23.86369  0.61719   22.90016  1.000 82.59405  ? 96  ASP A C     1 ? 
ATOM   743  O O     . ASP A 1 102 ? 24.80078  0.03178   23.45445  1.000 84.91257  ? 96  ASP A O     1 ? 
ATOM   744  C CB    . ASP A 1 102 ? 23.19294  0.53522   20.48700  1.000 77.29680  ? 96  ASP A CB    1 ? 
ATOM   745  C CG    . ASP A 1 102 ? 22.83691  -0.40625  19.35617  1.000 88.94520  ? 96  ASP A CG    1 ? 
ATOM   746  O OD1   . ASP A 1 102 ? 22.30217  -1.49844  19.63357  1.000 86.99579  ? 96  ASP A OD1   1 ? 
ATOM   747  O OD2   . ASP A 1 102 ? 23.09588  -0.05239  18.18647  1.000 94.32160  ? 96  ASP A OD2   1 ? 
ATOM   748  N N     . LYS A 1 103 ? 23.55518  1.88778   23.17430  1.000 86.88040  ? 97  LYS A N     1 ? 
ATOM   749  C CA    . LYS A 1 103 ? 24.41581  2.73099   23.99880  1.000 80.99502  ? 97  LYS A CA    1 ? 
ATOM   750  C C     . LYS A 1 103 ? 24.60328  2.19494   25.41324  1.000 83.63486  ? 97  LYS A C     1 ? 
ATOM   751  O O     . LYS A 1 103 ? 25.61398  2.50633   26.05317  1.000 89.90755  ? 97  LYS A O     1 ? 
ATOM   752  C CB    . LYS A 1 103 ? 23.83973  4.14628   24.05909  1.000 76.36339  ? 97  LYS A CB    1 ? 
ATOM   753  C CG    . LYS A 1 103 ? 24.75909  5.17624   24.69685  1.000 77.83128  ? 97  LYS A CG    1 ? 
ATOM   754  C CD    . LYS A 1 103 ? 23.95810  6.23390   25.43945  1.000 78.13813  ? 97  LYS A CD    1 ? 
ATOM   755  C CE    . LYS A 1 103 ? 24.75090  6.82242   26.59516  1.000 76.78508  ? 97  LYS A CE    1 ? 
ATOM   756  N NZ    . LYS A 1 103 ? 24.38473  8.24402   26.84242  1.000 78.90081  ? 97  LYS A NZ    1 ? 
ATOM   757  N N     . HIS A 1 104 ? 23.66346  1.39814   25.91887  1.000 77.52565  ? 98  HIS A N     1 ? 
ATOM   758  C CA    . HIS A 1 104 ? 23.73046  0.90733   27.28941  1.000 79.14860  ? 98  HIS A CA    1 ? 
ATOM   759  C C     . HIS A 1 104 ? 23.86176  -0.61332  27.36074  1.000 83.30782  ? 98  HIS A C     1 ? 
ATOM   760  O O     . HIS A 1 104 ? 23.82879  -1.17484  28.46227  1.000 84.22938  ? 98  HIS A O     1 ? 
ATOM   761  C CB    . HIS A 1 104 ? 22.49970  1.38212   28.07300  1.000 68.89693  ? 98  HIS A CB    1 ? 
ATOM   762  C CG    . HIS A 1 104 ? 22.43879  2.86449   28.27373  1.000 76.11740  ? 98  HIS A CG    1 ? 
ATOM   763  N ND1   . HIS A 1 104 ? 22.69420  3.45922   29.48801  1.000 80.21709  ? 98  HIS A ND1   1 ? 
ATOM   764  C CD2   . HIS A 1 104 ? 22.14682  3.86869   27.41391  1.000 80.70956  ? 98  HIS A CD2   1 ? 
ATOM   765  C CE1   . HIS A 1 104 ? 22.56288  4.76936   29.37051  1.000 77.56930  ? 98  HIS A CE1   1 ? 
ATOM   766  N NE2   . HIS A 1 104 ? 22.23148  5.04288   28.12285  1.000 80.37574  ? 98  HIS A NE2   1 ? 
ATOM   767  N N     . ASP A 1 105 ? 23.99650  -1.29169  26.21985  1.000 84.60652  ? 99  ASP A N     1 ? 
ATOM   768  C CA    . ASP A 1 105 ? 24.21494  -2.74141  26.15602  1.000 85.38464  ? 99  ASP A CA    1 ? 
ATOM   769  C C     . ASP A 1 105 ? 23.15120  -3.51652  26.94339  1.000 87.13304  ? 99  ASP A C     1 ? 
ATOM   770  O O     . ASP A 1 105 ? 23.45052  -4.30406  27.84270  1.000 99.08358  ? 99  ASP A O     1 ? 
ATOM   771  C CB    . ASP A 1 105 ? 25.62577  -3.09947  26.64260  1.000 83.96221  ? 99  ASP A CB    1 ? 
ATOM   772  C CG    . ASP A 1 105 ? 26.10360  -4.46146  26.13703  1.000 98.16706  ? 99  ASP A CG    1 ? 
ATOM   773  O OD1   . ASP A 1 105 ? 27.28207  -4.81082  26.37353  1.000 102.81714 ? 99  ASP A OD1   1 ? 
ATOM   774  O OD2   . ASP A 1 105 ? 25.30930  -5.18583  25.49951  1.000 100.57619 ? 99  ASP A OD2   1 ? 
ATOM   775  N N     . LEU A 1 106 ? 21.88765  -3.30028  26.56724  1.000 83.89905  ? 100 LEU A N     1 ? 
ATOM   776  C CA    . LEU A 1 106 ? 20.78469  -4.05605  27.16021  1.000 80.91893  ? 100 LEU A CA    1 ? 
ATOM   777  C C     . LEU A 1 106 ? 20.54019  -5.39595  26.47144  1.000 84.63111  ? 100 LEU A C     1 ? 
ATOM   778  O O     . LEU A 1 106 ? 20.17236  -6.36812  27.14197  1.000 83.13412  ? 100 LEU A O     1 ? 
ATOM   779  C CB    . LEU A 1 106 ? 19.49670  -3.22517  27.14348  1.000 77.20522  ? 100 LEU A CB    1 ? 
ATOM   780  C CG    . LEU A 1 106 ? 19.21225  -2.16041  28.20827  1.000 76.87449  ? 100 LEU A CG    1 ? 
ATOM   781  C CD1   . LEU A 1 106 ? 20.41442  -1.26013  28.45023  1.000 79.45526  ? 100 LEU A CD1   1 ? 
ATOM   782  C CD2   . LEU A 1 106 ? 17.97826  -1.34728  27.80678  1.000 85.25221  ? 100 LEU A CD2   1 ? 
ATOM   783  N N     . ARG A 1 107 ? 20.76664  -5.47728  25.15633  1.000 85.95648  ? 101 ARG A N     1 ? 
ATOM   784  C CA    . ARG A 1 107 ? 20.30544  -6.62840  24.38224  1.000 82.31865  ? 101 ARG A CA    1 ? 
ATOM   785  C C     . ARG A 1 107 ? 20.84695  -7.94820  24.91564  1.000 90.39800  ? 101 ARG A C     1 ? 
ATOM   786  O O     . ARG A 1 107 ? 20.20892  -8.99254  24.73879  1.000 78.25443  ? 101 ARG A O     1 ? 
ATOM   787  C CB    . ARG A 1 107 ? 20.68292  -6.45469  22.91431  1.000 76.94005  ? 101 ARG A CB    1 ? 
ATOM   788  C CG    . ARG A 1 107 ? 19.82293  -5.43650  22.19366  1.000 85.78288  ? 101 ARG A CG    1 ? 
ATOM   789  C CD    . ARG A 1 107 ? 19.68104  -5.77821  20.72330  1.000 80.09645  ? 101 ARG A CD    1 ? 
ATOM   790  N NE    . ARG A 1 107 ? 19.24158  -4.63457  19.93274  1.000 76.07160  ? 101 ARG A NE    1 ? 
ATOM   791  C CZ    . ARG A 1 107 ? 19.99003  -3.57503  19.65639  1.000 85.42441  ? 101 ARG A CZ    1 ? 
ATOM   792  N NH1   . ARG A 1 107 ? 21.23545  -3.47379  20.09161  1.000 102.45740 ? 101 ARG A NH1   1 ? 
ATOM   793  N NH2   . ARG A 1 107 ? 19.47638  -2.59245  18.92187  1.000 87.24549  ? 101 ARG A NH2   1 ? 
ATOM   794  N N     . LYS A 1 108 ? 22.00349  -7.92781  25.57964  1.000 90.06414  ? 102 LYS A N     1 ? 
ATOM   795  C CA    . LYS A 1 108 ? 22.55008  -9.15842  26.13671  1.000 85.64994  ? 102 LYS A CA    1 ? 
ATOM   796  C C     . LYS A 1 108 ? 21.71170  -9.71580  27.28108  1.000 82.28703  ? 102 LYS A C     1 ? 
ATOM   797  O O     . LYS A 1 108 ? 21.93274  -10.86346 27.68134  1.000 88.65469  ? 102 LYS A O     1 ? 
ATOM   798  C CB    . LYS A 1 108 ? 23.98791  -8.93263  26.61115  1.000 85.70686  ? 102 LYS A CB    1 ? 
ATOM   799  C CG    . LYS A 1 108 ? 24.11337  -8.11352  27.88392  1.000 94.87383  ? 102 LYS A CG    1 ? 
ATOM   800  C CD    . LYS A 1 108 ? 25.57466  -7.93061  28.26425  1.000 95.58900  ? 102 LYS A CD    1 ? 
ATOM   801  C CE    . LYS A 1 108 ? 25.71949  -7.17589  29.57407  1.000 98.12394  ? 102 LYS A CE    1 ? 
ATOM   802  N NZ    . LYS A 1 108 ? 26.86845  -6.23014  29.54029  1.000 101.77886 ? 102 LYS A NZ    1 ? 
ATOM   803  N N     . ASP A 1 109 ? 20.75712  -8.94951  27.80949  1.000 76.46548  ? 103 ASP A N     1 ? 
ATOM   804  C CA    . ASP A 1 109 ? 19.91487  -9.40899  28.90638  1.000 75.12898  ? 103 ASP A CA    1 ? 
ATOM   805  C C     . ASP A 1 109 ? 18.44421  -9.55193  28.52354  1.000 80.26564  ? 103 ASP A C     1 ? 
ATOM   806  O O     . ASP A 1 109 ? 17.61100  -9.77635  29.40769  1.000 79.51841  ? 103 ASP A O     1 ? 
ATOM   807  C CB    . ASP A 1 109 ? 20.05276  -8.47633  30.11253  1.000 79.33266  ? 103 ASP A CB    1 ? 
ATOM   808  C CG    . ASP A 1 109 ? 21.23629  -8.83409  30.99272  1.000 87.84963  ? 103 ASP A CG    1 ? 
ATOM   809  O OD1   . ASP A 1 109 ? 21.22668  -9.93417  31.58520  1.000 85.31309  ? 103 ASP A OD1   1 ? 
ATOM   810  O OD2   . ASP A 1 109 ? 22.17229  -8.01485  31.09444  1.000 86.31966  ? 103 ASP A OD2   1 ? 
ATOM   811  N N     . ILE A 1 110 ? 18.09524  -9.42270  27.24240  1.000 79.61394  ? 104 ILE A N     1 ? 
ATOM   812  C CA    . ILE A 1 110 ? 16.76728  -9.78588  26.75448  1.000 79.35085  ? 104 ILE A CA    1 ? 
ATOM   813  C C     . ILE A 1 110 ? 16.88431  -11.02508 25.87879  1.000 74.93369  ? 104 ILE A C     1 ? 
ATOM   814  O O     . ILE A 1 110 ? 17.83470  -11.16675 25.09867  1.000 74.85041  ? 104 ILE A O     1 ? 
ATOM   815  C CB    . ILE A 1 110 ? 16.04159  -8.65592  25.98776  1.000 80.91220  ? 104 ILE A CB    1 ? 
ATOM   816  C CG1   . ILE A 1 110 ? 16.18378  -7.28777  26.67220  1.000 68.04999  ? 104 ILE A CG1   1 ? 
ATOM   817  C CG2   . ILE A 1 110 ? 14.56337  -9.01045  25.77861  1.000 83.12234  ? 104 ILE A CG2   1 ? 
ATOM   818  C CD1   . ILE A 1 110 ? 17.28733  -6.41367  26.15940  1.000 83.27876  ? 104 ILE A CD1   1 ? 
ATOM   819  N N     . GLN A 1 111 ? 15.91647  -11.92907 26.02596  1.000 67.58953  ? 105 GLN A N     1 ? 
ATOM   820  C CA    . GLN A 1 111 ? 15.79489  -13.13251 25.21194  1.000 80.57148  ? 105 GLN A CA    1 ? 
ATOM   821  C C     . GLN A 1 111 ? 14.63503  -12.92010 24.24802  1.000 78.82468  ? 105 GLN A C     1 ? 
ATOM   822  O O     . GLN A 1 111 ? 13.46817  -12.95467 24.65417  1.000 73.46690  ? 105 GLN A O     1 ? 
ATOM   823  C CB    . GLN A 1 111 ? 15.56742  -14.36306 26.08646  1.000 83.72150  ? 105 GLN A CB    1 ? 
ATOM   824  C CG    . GLN A 1 111 ? 16.17803  -15.63617 25.53536  1.000 90.43038  ? 105 GLN A CG    1 ? 
ATOM   825  C CD    . GLN A 1 111 ? 16.22960  -16.74426 26.56534  1.000 102.32379 ? 105 GLN A CD    1 ? 
ATOM   826  O OE1   . GLN A 1 111 ? 15.21297  -17.36459 26.87628  1.000 92.73063  ? 105 GLN A OE1   1 ? 
ATOM   827  N NE2   . GLN A 1 111 ? 17.41783  -17.00134 27.10026  1.000 92.32408  ? 105 GLN A NE2   1 ? 
ATOM   828  N N     . PHE A 1 112 ? 14.95582  -12.69219 22.97927  1.000 82.70483  ? 106 PHE A N     1 ? 
ATOM   829  C CA    . PHE A 1 112 ? 13.93528  -12.42947 21.98037  1.000 77.71671  ? 106 PHE A CA    1 ? 
ATOM   830  C C     . PHE A 1 112 ? 13.31398  -13.73648 21.49215  1.000 83.79452  ? 106 PHE A C     1 ? 
ATOM   831  O O     . PHE A 1 112 ? 13.80498  -14.83423 21.77107  1.000 85.12832  ? 106 PHE A O     1 ? 
ATOM   832  C CB    . PHE A 1 112 ? 14.52615  -11.64040 20.81410  1.000 74.34702  ? 106 PHE A CB    1 ? 
ATOM   833  C CG    . PHE A 1 112 ? 15.14633  -10.33511 21.22196  1.000 72.39444  ? 106 PHE A CG    1 ? 
ATOM   834  C CD1   . PHE A 1 112 ? 14.35599  -9.22445  21.46641  1.000 78.72390  ? 106 PHE A CD1   1 ? 
ATOM   835  C CD2   . PHE A 1 112 ? 16.51897  -10.21913 21.36474  1.000 76.07100  ? 106 PHE A CD2   1 ? 
ATOM   836  C CE1   . PHE A 1 112 ? 14.92308  -8.02156  21.84434  1.000 75.26450  ? 106 PHE A CE1   1 ? 
ATOM   837  C CE2   . PHE A 1 112 ? 17.09220  -9.01877  21.74166  1.000 79.17457  ? 106 PHE A CE2   1 ? 
ATOM   838  C CZ    . PHE A 1 112 ? 16.29293  -7.91880  21.98160  1.000 74.70466  ? 106 PHE A CZ    1 ? 
ATOM   839  N N     . GLU A 1 113 ? 12.20709  -13.60130 20.75665  1.000 85.32427  ? 107 GLU A N     1 ? 
ATOM   840  C CA    . GLU A 1 113 ? 11.45674  -14.73911 20.22092  1.000 88.96545  ? 107 GLU A CA    1 ? 
ATOM   841  C C     . GLU A 1 113 ? 11.00113  -15.68811 21.32544  1.000 89.37116  ? 107 GLU A C     1 ? 
ATOM   842  O O     . GLU A 1 113 ? 10.87443  -16.89539 21.10741  1.000 103.13734 ? 107 GLU A O     1 ? 
ATOM   843  C CB    . GLU A 1 113 ? 12.27140  -15.50251 19.17157  1.000 89.27454  ? 107 GLU A CB    1 ? 
ATOM   844  C CG    . GLU A 1 113 ? 12.29077  -14.85672 17.79864  1.000 95.82541  ? 107 GLU A CG    1 ? 
ATOM   845  C CD    . GLU A 1 113 ? 13.62342  -15.03128 17.09702  1.000 106.60966 ? 107 GLU A CD    1 ? 
ATOM   846  O OE1   . GLU A 1 113 ? 14.46490  -15.80320 17.60357  1.000 110.03755 ? 107 GLU A OE1   1 ? 
ATOM   847  O OE2   . GLU A 1 113 ? 13.82968  -14.39965 16.03941  1.000 99.10857  ? 107 GLU A OE2   1 ? 
ATOM   848  N N     . THR A 1 114 ? 10.74712  -15.15345 22.51821  1.000 82.10595  ? 108 THR A N     1 ? 
ATOM   849  C CA    . THR A 1 114 ? 10.41140  -15.96204 23.68903  1.000 75.27681  ? 108 THR A CA    1 ? 
ATOM   850  C C     . THR A 1 114 ? 9.18253   -15.36413 24.36636  1.000 81.16527  ? 108 THR A C     1 ? 
ATOM   851  O O     . THR A 1 114 ? 9.29091   -14.38862 25.11543  1.000 92.17964  ? 108 THR A O     1 ? 
ATOM   852  C CB    . THR A 1 114 ? 11.58791  -16.03847 24.65806  1.000 83.71257  ? 108 THR A CB    1 ? 
ATOM   853  O OG1   . THR A 1 114 ? 12.80725  -16.19579 23.92141  1.000 84.02657  ? 108 THR A OG1   1 ? 
ATOM   854  C CG2   . THR A 1 114 ? 11.41976  -17.21509 25.60691  1.000 78.43589  ? 108 THR A CG2   1 ? 
ATOM   855  N N     . GLY A 1 115 ? 8.01939   -15.94967 24.10383  1.000 89.62866  ? 109 GLY A N     1 ? 
ATOM   856  C CA    . GLY A 1 115 ? 6.81498   -15.55271 24.79853  1.000 89.52391  ? 109 GLY A CA    1 ? 
ATOM   857  C C     . GLY A 1 115 ? 6.78544   -16.07882 26.22100  1.000 93.73142  ? 109 GLY A C     1 ? 
ATOM   858  O O     . GLY A 1 115 ? 7.65006   -16.83611 26.66368  1.000 100.66208 ? 109 GLY A O     1 ? 
ATOM   859  N N     . ILE A 1 116 ? 5.75869   -15.66050 26.95535  1.000 85.58379  ? 110 ILE A N     1 ? 
ATOM   860  C CA    . ILE A 1 116 ? 5.55504   -16.07537 28.33885  1.000 90.53226  ? 110 ILE A CA    1 ? 
ATOM   861  C C     . ILE A 1 116 ? 4.19091   -16.74260 28.43182  1.000 91.05681  ? 110 ILE A C     1 ? 
ATOM   862  O O     . ILE A 1 116 ? 3.16162   -16.09857 28.19175  1.000 75.66577  ? 110 ILE A O     1 ? 
ATOM   863  C CB    . ILE A 1 116 ? 5.65573   -14.89236 29.31453  1.000 85.16634  ? 110 ILE A CB    1 ? 
ATOM   864  C CG1   . ILE A 1 116 ? 7.08220   -14.33877 29.33629  1.000 79.38702  ? 110 ILE A CG1   1 ? 
ATOM   865  C CG2   . ILE A 1 116 ? 5.22597   -15.31625 30.71115  1.000 73.97953  ? 110 ILE A CG2   1 ? 
ATOM   866  C CD1   . ILE A 1 116 ? 8.14004   -15.38234 29.61554  1.000 79.11309  ? 110 ILE A CD1   1 ? 
ATOM   867  N N     . ARG A 1 117 ? 4.18229   -18.03057 28.77987  1.000 94.84335  ? 111 ARG A N     1 ? 
ATOM   868  C CA    . ARG A 1 117 ? 2.92554   -18.76479 28.88475  1.000 95.27773  ? 111 ARG A CA    1 ? 
ATOM   869  C C     . ARG A 1 117 ? 2.28908   -18.58013 30.25763  1.000 92.71652  ? 111 ARG A C     1 ? 
ATOM   870  O O     . ARG A 1 117 ? 1.15746   -18.09691 30.37066  1.000 88.75142  ? 111 ARG A O     1 ? 
ATOM   871  C CB    . ARG A 1 117 ? 3.15248   -20.25260 28.59838  1.000 91.98399  ? 111 ARG A CB    1 ? 
ATOM   872  C CG    . ARG A 1 117 ? 1.88636   -21.09319 28.70042  1.000 99.32539  ? 111 ARG A CG    1 ? 
ATOM   873  C CD    . ARG A 1 117 ? 2.09403   -22.49361 28.14830  1.000 109.53462 ? 111 ARG A CD    1 ? 
ATOM   874  N NE    . ARG A 1 117 ? 3.30733   -23.12272 28.65573  1.000 103.26282 ? 111 ARG A NE    1 ? 
ATOM   875  C CZ    . ARG A 1 117 ? 4.24123   -23.67019 27.89036  1.000 104.99570 ? 111 ARG A CZ    1 ? 
ATOM   876  N NH1   . ARG A 1 117 ? 4.16971   -23.61972 26.57098  1.000 98.38904  ? 111 ARG A NH1   1 ? 
ATOM   877  N NH2   . ARG A 1 117 ? 5.27604   -24.27811 28.46299  1.000 104.38254 ? 111 ARG A NH2   1 ? 
ATOM   878  N N     . SER A 1 118 ? 3.00564   -18.95675 31.31379  1.000 91.52414  ? 112 SER A N     1 ? 
ATOM   879  C CA    . SER A 1 118 ? 2.45465   -18.96809 32.65890  1.000 89.00040  ? 112 SER A CA    1 ? 
ATOM   880  C C     . SER A 1 118 ? 3.40177   -18.27243 33.62469  1.000 89.39285  ? 112 SER A C     1 ? 
ATOM   881  O O     . SER A 1 118 ? 4.62332   -18.29687 33.45192  1.000 87.80227  ? 112 SER A O     1 ? 
ATOM   882  C CB    . SER A 1 118 ? 2.19088   -20.40181 33.13864  1.000 98.73066  ? 112 SER A CB    1 ? 
ATOM   883  O OG    . SER A 1 118 ? 1.09778   -20.97979 32.44704  1.000 104.07891 ? 112 SER A OG    1 ? 
ATOM   884  N N     . ALA A 1 119 ? 2.81795   -17.65149 34.64916  1.000 88.91563  ? 113 ALA A N     1 ? 
ATOM   885  C CA    . ALA A 1 119 ? 3.57538   -17.02026 35.73022  1.000 87.01991  ? 113 ALA A CA    1 ? 
ATOM   886  C C     . ALA A 1 119 ? 2.88521   -17.39482 37.03816  1.000 90.56364  ? 113 ALA A C     1 ? 
ATOM   887  O O     . ALA A 1 119 ? 1.83878   -16.83384 37.37673  1.000 90.50137  ? 113 ALA A O     1 ? 
ATOM   888  C CB    . ALA A 1 119 ? 3.65640   -15.50890 35.55218  1.000 78.77403  ? 113 ALA A CB    1 ? 
ATOM   889  N N     . TYR A 1 120 ? 3.46791   -18.34453 37.76388  1.000 91.38354  ? 114 TYR A N     1 ? 
ATOM   890  C CA    . TYR A 1 120 ? 2.89140   -18.86438 38.99630  1.000 92.40762  ? 114 TYR A CA    1 ? 
ATOM   891  C C     . TYR A 1 120 ? 3.72699   -18.40824 40.18291  1.000 91.39596  ? 114 TYR A C     1 ? 
ATOM   892  O O     . TYR A 1 120 ? 4.95079   -18.57530 40.18625  1.000 85.07573  ? 114 TYR A O     1 ? 
ATOM   893  C CB    . TYR A 1 120 ? 2.81637   -20.39268 38.96508  1.000 102.04493 ? 114 TYR A CB    1 ? 
ATOM   894  C CG    . TYR A 1 120 ? 1.87828   -20.94814 37.91726  1.000 98.59662  ? 114 TYR A CG    1 ? 
ATOM   895  C CD1   . TYR A 1 120 ? 0.88259   -20.15858 37.35732  1.000 96.04788  ? 114 TYR A CD1   1 ? 
ATOM   896  C CD2   . TYR A 1 120 ? 1.98660   -22.26536 37.49135  1.000 101.97652 ? 114 TYR A CD2   1 ? 
ATOM   897  C CE1   . TYR A 1 120 ? 0.02474   -20.66345 36.39971  1.000 98.10656  ? 114 TYR A CE1   1 ? 
ATOM   898  C CE2   . TYR A 1 120 ? 1.13241   -22.77967 36.53573  1.000 96.02836  ? 114 TYR A CE2   1 ? 
ATOM   899  C CZ    . TYR A 1 120 ? 0.15341   -21.97473 35.99335  1.000 98.55609  ? 114 TYR A CZ    1 ? 
ATOM   900  O OH    . TYR A 1 120 ? -0.69948  -22.48313 35.04096  1.000 101.29949 ? 114 TYR A OH    1 ? 
ATOM   901  N N     . PHE A 1 121 ? 3.06656   -17.83911 41.18696  1.000 93.90526  ? 115 PHE A N     1 ? 
ATOM   902  C CA    . PHE A 1 121 ? 3.75840   -17.40354 42.39108  1.000 92.54222  ? 115 PHE A CA    1 ? 
ATOM   903  C C     . PHE A 1 121 ? 3.91715   -18.57070 43.35712  1.000 97.63920  ? 115 PHE A C     1 ? 
ATOM   904  O O     . PHE A 1 121 ? 2.93772   -19.23635 43.70758  1.000 99.44975  ? 115 PHE A O     1 ? 
ATOM   905  C CB    . PHE A 1 121 ? 2.99890   -16.26837 43.07573  1.000 91.06187  ? 115 PHE A CB    1 ? 
ATOM   906  C CG    . PHE A 1 121 ? 3.72697   -15.68483 44.25262  1.000 93.79017  ? 115 PHE A CG    1 ? 
ATOM   907  C CD1   . PHE A 1 121 ? 5.10933   -15.61480 44.26133  1.000 93.56445  ? 115 PHE A CD1   1 ? 
ATOM   908  C CD2   . PHE A 1 121 ? 3.03621   -15.25477 45.36947  1.000 93.79885  ? 115 PHE A CD2   1 ? 
ATOM   909  C CE1   . PHE A 1 121 ? 5.78754   -15.09322 45.34481  1.000 97.98064  ? 115 PHE A CE1   1 ? 
ATOM   910  C CE2   . PHE A 1 121 ? 3.71216   -14.73920 46.45845  1.000 87.87114  ? 115 PHE A CE2   1 ? 
ATOM   911  C CZ    . PHE A 1 121 ? 5.08584   -14.65563 46.44527  1.000 97.69186  ? 115 PHE A CZ    1 ? 
ATOM   912  N N     . ASP A 1 122 ? 5.15111   -18.81115 43.79164  1.000 99.21077  ? 116 ASP A N     1 ? 
ATOM   913  C CA    . ASP A 1 122 ? 5.43233   -19.80117 44.82190  1.000 108.40418 ? 116 ASP A CA    1 ? 
ATOM   914  C C     . ASP A 1 122 ? 5.25533   -19.15694 46.19115  1.000 107.55165 ? 116 ASP A C     1 ? 
ATOM   915  O O     . ASP A 1 122 ? 5.86599   -18.12341 46.48035  1.000 105.62815 ? 116 ASP A O     1 ? 
ATOM   916  C CB    . ASP A 1 122 ? 6.85063   -20.35383 44.66820  1.000 107.91322 ? 116 ASP A CB    1 ? 
ATOM   917  C CG    . ASP A 1 122 ? 7.04360   -21.68251 45.37617  1.000 112.00212 ? 116 ASP A CG    1 ? 
ATOM   918  O OD1   . ASP A 1 122 ? 6.26900   -21.98646 46.30776  1.000 116.58069 ? 116 ASP A OD1   1 ? 
ATOM   919  O OD2   . ASP A 1 122 ? 7.97645   -22.42389 45.00084  1.000 102.72628 ? 116 ASP A OD2   1 ? 
ATOM   920  N N     . GLU A 1 123 ? 4.41612   -19.76462 47.02761  1.000 108.53122 ? 117 GLU A N     1 ? 
ATOM   921  C CA    . GLU A 1 123 ? 4.10998   -19.20969 48.33891  1.000 106.79134 ? 117 GLU A CA    1 ? 
ATOM   922  C C     . GLU A 1 123 ? 5.09271   -19.63822 49.42047  1.000 99.79841  ? 117 GLU A C     1 ? 
ATOM   923  O O     . GLU A 1 123 ? 5.04475   -19.09144 50.52766  1.000 93.30985  ? 117 GLU A O     1 ? 
ATOM   924  C CB    . GLU A 1 123 ? 2.68933   -19.60036 48.75905  1.000 109.22744 ? 117 GLU A CB    1 ? 
ATOM   925  C CG    . GLU A 1 123 ? 1.64156   -18.54844 48.43729  1.000 93.71897  ? 117 GLU A CG    1 ? 
ATOM   926  C CD    . GLU A 1 123 ? 0.23383   -19.10775 48.44740  1.000 110.39344 ? 117 GLU A CD    1 ? 
ATOM   927  O OE1   . GLU A 1 123 ? 0.01437   -20.15879 49.08517  1.000 117.44445 ? 117 GLU A OE1   1 ? 
ATOM   928  O OE2   . GLU A 1 123 ? -0.65377  -18.49681 47.81733  1.000 110.91653 ? 117 GLU A OE2   1 ? 
ATOM   929  N N     . GLU A 1 124 ? 5.97554   -20.59408 49.13487  1.000 104.49430 ? 118 GLU A N     1 ? 
ATOM   930  C CA    . GLU A 1 124 ? 6.97465   -21.03402 50.11799  1.000 116.28107 ? 118 GLU A CA    1 ? 
ATOM   931  C C     . GLU A 1 124 ? 8.21844   -20.16227 50.02821  1.000 115.53995 ? 118 GLU A C     1 ? 
ATOM   932  O O     . GLU A 1 124 ? 8.47742   -19.33517 50.91475  1.000 116.70612 ? 118 GLU A O     1 ? 
ATOM   933  C CB    . GLU A 1 124 ? 7.31205   -22.51242 49.90733  1.000 117.98529 ? 118 GLU A CB    1 ? 
ATOM   934  C CG    . GLU A 1 124 ? 8.39265   -23.03479 50.84162  1.000 120.19823 ? 118 GLU A CG    1 ? 
ATOM   935  C CD    . GLU A 1 124 ? 8.12438   -24.44983 51.31325  1.000 125.66029 ? 118 GLU A CD    1 ? 
ATOM   936  O OE1   . GLU A 1 124 ? 7.32973   -25.15624 50.65803  1.000 124.24732 ? 118 GLU A OE1   1 ? 
ATOM   937  O OE2   . GLU A 1 124 ? 8.70873   -24.85567 52.33996  1.000 123.37820 ? 118 GLU A OE2   1 ? 
ATOM   938  N N     . ASN A 1 125 ? 9.00242   -20.32819 48.96227  1.000 115.36603 ? 119 ASN A N     1 ? 
ATOM   939  C CA    . ASN A 1 125 ? 10.21729  -19.54419 48.78373  1.000 119.20178 ? 119 ASN A CA    1 ? 
ATOM   940  C C     . ASN A 1 125 ? 9.93890   -18.11242 48.34599  1.000 110.91990 ? 119 ASN A C     1 ? 
ATOM   941  O O     . ASN A 1 125 ? 10.88291  -17.31960 48.25504  1.000 112.92733 ? 119 ASN A O     1 ? 
ATOM   942  C CB    . ASN A 1 125 ? 11.13326  -20.22748 47.76936  1.000 116.24674 ? 119 ASN A CB    1 ? 
ATOM   943  C CG    . ASN A 1 125 ? 12.18862  -21.09370 48.42703  1.000 124.18268 ? 119 ASN A CG    1 ? 
ATOM   944  O OD1   . ASN A 1 125 ? 12.32721  -21.10275 49.65028  1.000 127.36176 ? 119 ASN A OD1   1 ? 
ATOM   945  N ND2   . ASN A 1 125 ? 12.93994  -21.82913 47.61576  1.000 125.10664 ? 119 ASN A ND2   1 ? 
ATOM   946  N N     . SER A 1 126 ? 8.67978   -17.77330 48.06512  1.000 107.03433 ? 120 SER A N     1 ? 
ATOM   947  C CA    . SER A 1 126 ? 8.26093   -16.40912 47.74342  1.000 103.52286 ? 120 SER A CA    1 ? 
ATOM   948  C C     . SER A 1 126 ? 8.94965   -15.89402 46.47622  1.000 107.12529 ? 120 SER A C     1 ? 
ATOM   949  O O     . SER A 1 126 ? 9.62425   -14.86217 46.47575  1.000 104.02599 ? 120 SER A O     1 ? 
ATOM   950  C CB    . SER A 1 126 ? 8.50653   -15.46852 48.92962  1.000 101.09211 ? 120 SER A CB    1 ? 
ATOM   951  O OG    . SER A 1 126 ? 7.29334   -14.90129 49.39310  1.000 97.46992  ? 120 SER A OG    1 ? 
ATOM   952  N N     . PHE A 1 127 ? 8.76438   -16.63561 45.38480  1.000 102.29364 ? 121 PHE A N     1 ? 
ATOM   953  C CA    . PHE A 1 127 ? 9.17806   -16.16154 44.07136  1.000 95.22203  ? 121 PHE A CA    1 ? 
ATOM   954  C C     . PHE A 1 127 ? 8.19745   -16.67384 43.02398  1.000 94.60745  ? 121 PHE A C     1 ? 
ATOM   955  O O     . PHE A 1 127 ? 7.30223   -17.47025 43.31546  1.000 99.78178  ? 121 PHE A O     1 ? 
ATOM   956  C CB    . PHE A 1 127 ? 10.63367  -16.55399 43.74470  1.000 97.08333  ? 121 PHE A CB    1 ? 
ATOM   957  C CG    . PHE A 1 127 ? 10.93492  -18.03466 43.82929  1.000 95.75689  ? 121 PHE A CG    1 ? 
ATOM   958  C CD1   . PHE A 1 127 ? 10.16914  -18.97525 43.15608  1.000 97.84815  ? 121 PHE A CD1   1 ? 
ATOM   959  C CD2   . PHE A 1 127 ? 12.02921  -18.47578 44.55445  1.000 105.22904 ? 121 PHE A CD2   1 ? 
ATOM   960  C CE1   . PHE A 1 127 ? 10.46853  -20.32094 43.23126  1.000 101.80292 ? 121 PHE A CE1   1 ? 
ATOM   961  C CE2   . PHE A 1 127 ? 12.33631  -19.82038 44.62772  1.000 95.87985  ? 121 PHE A CE2   1 ? 
ATOM   962  C CZ    . PHE A 1 127 ? 11.55352  -20.74362 43.96854  1.000 92.71811  ? 121 PHE A CZ    1 ? 
ATOM   963  N N     . TRP A 1 128 ? 8.38689   -16.21487 41.79099  1.000 90.15059  ? 122 TRP A N     1 ? 
ATOM   964  C CA    . TRP A 1 128 ? 7.48917   -16.52794 40.68987  1.000 85.80405  ? 122 TRP A CA    1 ? 
ATOM   965  C C     . TRP A 1 128 ? 8.03863   -17.66940 39.84136  1.000 89.18088  ? 122 TRP A C     1 ? 
ATOM   966  O O     . TRP A 1 128 ? 9.25263   -17.83668 39.69794  1.000 80.74424  ? 122 TRP A O     1 ? 
ATOM   967  C CB    . TRP A 1 128 ? 7.26176   -15.29567 39.81092  1.000 74.63612  ? 122 TRP A CB    1 ? 
ATOM   968  C CG    . TRP A 1 128 ? 6.31871   -14.29702 40.40796  1.000 76.02226  ? 122 TRP A CG    1 ? 
ATOM   969  C CD1   . TRP A 1 128 ? 6.64285   -13.23628 41.20269  1.000 74.98075  ? 122 TRP A CD1   1 ? 
ATOM   970  C CD2   . TRP A 1 128 ? 4.89446   -14.26376 40.25590  1.000 71.54063  ? 122 TRP A CD2   1 ? 
ATOM   971  N NE1   . TRP A 1 128 ? 5.50881   -12.54573 41.55635  1.000 65.80702  ? 122 TRP A NE1   1 ? 
ATOM   972  C CE2   . TRP A 1 128 ? 4.42209   -13.15649 40.98786  1.000 68.69134  ? 122 TRP A CE2   1 ? 
ATOM   973  C CE3   . TRP A 1 128 ? 3.97319   -15.06291 39.57242  1.000 64.77091  ? 122 TRP A CE3   1 ? 
ATOM   974  C CZ2   . TRP A 1 128 ? 3.06964   -12.82861 41.05550  1.000 73.27685  ? 122 TRP A CZ2   1 ? 
ATOM   975  C CZ3   . TRP A 1 128 ? 2.63113   -14.73608 39.64175  1.000 72.11046  ? 122 TRP A CZ3   1 ? 
ATOM   976  C CH2   . TRP A 1 128 ? 2.19229   -13.62884 40.37742  1.000 72.34230  ? 122 TRP A CH2   1 ? 
ATOM   977  N N     . ASN A 1 129 ? 7.12258   -18.45599 39.27884  1.000 85.26789  ? 123 ASN A N     1 ? 
ATOM   978  C CA    . ASN A 1 129 ? 7.44493   -19.53453 38.34626  1.000 81.61723  ? 123 ASN A CA    1 ? 
ATOM   979  C C     . ASN A 1 129 ? 6.97767   -19.08957 36.96473  1.000 86.56169  ? 123 ASN A C     1 ? 
ATOM   980  O O     . ASN A 1 129 ? 5.78794   -19.17130 36.64723  1.000 91.96824  ? 123 ASN A O     1 ? 
ATOM   981  C CB    . ASN A 1 129 ? 6.77997   -20.84398 38.76298  1.000 85.15145  ? 123 ASN A CB    1 ? 
ATOM   982  C CG    . ASN A 1 129 ? 7.49173   -21.52050 39.91711  1.000 94.96260  ? 123 ASN A CG    1 ? 
ATOM   983  O OD1   . ASN A 1 129 ? 8.67972   -21.83225 39.83296  1.000 91.63766  ? 123 ASN A OD1   1 ? 
ATOM   984  N ND2   . ASN A 1 129 ? 6.76465   -21.75602 41.00333  1.000 98.10232  ? 123 ASN A ND2   1 ? 
ATOM   985  N N     . VAL A 1 130 ? 7.91314   -18.61957 36.14625  1.000 91.61649  ? 124 VAL A N     1 ? 
ATOM   986  C CA    . VAL A 1 130 ? 7.60825   -18.06552 34.83217  1.000 97.01193  ? 124 VAL A CA    1 ? 
ATOM   987  C C     . VAL A 1 130 ? 8.00708   -19.10065 33.78842  1.000 93.62077  ? 124 VAL A C     1 ? 
ATOM   988  O O     . VAL A 1 130 ? 9.19762   -19.37292 33.59305  1.000 94.12203  ? 124 VAL A O     1 ? 
ATOM   989  C CB    . VAL A 1 130 ? 8.32363   -16.72686 34.59968  1.000 86.77638  ? 124 VAL A CB    1 ? 
ATOM   990  C CG1   . VAL A 1 130 ? 8.42836   -16.41771 33.11086  1.000 85.34059  ? 124 VAL A CG1   1 ? 
ATOM   991  C CG2   . VAL A 1 130 ? 7.60106   -15.60696 35.33304  1.000 80.01599  ? 124 VAL A CG2   1 ? 
ATOM   992  N N     . THR A 1 131 ? 7.01207   -19.68335 33.12409  1.000 89.70215  ? 125 THR A N     1 ? 
ATOM   993  C CA    . THR A 1 131 ? 7.22487   -20.65069 32.05467  1.000 94.98721  ? 125 THR A CA    1 ? 
ATOM   994  C C     . THR A 1 131 ? 7.08050   -19.96146 30.70443  1.000 93.31440  ? 125 THR A C     1 ? 
ATOM   995  O O     . THR A 1 131 ? 6.05828   -19.32114 30.43584  1.000 90.09783  ? 125 THR A O     1 ? 
ATOM   996  C CB    . THR A 1 131 ? 6.22628   -21.80749 32.15267  1.000 94.15129  ? 125 THR A CB    1 ? 
ATOM   997  O OG1   . THR A 1 131 ? 5.37325   -21.61560 33.28874  1.000 95.16731  ? 125 THR A OG1   1 ? 
ATOM   998  C CG2   . THR A 1 131 ? 6.93700   -23.14863 32.25816  1.000 87.16226  ? 125 THR A CG2   1 ? 
ATOM   999  N N     . THR A 1 132 ? 8.10059   -20.09180 29.86032  1.000 92.17106  ? 126 THR A N     1 ? 
ATOM   1000 C CA    . THR A 1 132 ? 8.01843   -19.57170 28.50550  1.000 87.75682  ? 126 THR A CA    1 ? 
ATOM   1001 C C     . THR A 1 132 ? 7.19406   -20.51721 27.63449  1.000 96.29388  ? 126 THR A C     1 ? 
ATOM   1002 O O     . THR A 1 132 ? 6.74185   -21.57899 28.07245  1.000 91.51421  ? 126 THR A O     1 ? 
ATOM   1003 C CB    . THR A 1 132 ? 9.41388   -19.36973 27.91668  1.000 93.48368  ? 126 THR A CB    1 ? 
ATOM   1004 O OG1   . THR A 1 132 ? 9.85271   -20.58210 27.28964  1.000 93.29872  ? 126 THR A OG1   1 ? 
ATOM   1005 C CG2   . THR A 1 132 ? 10.40513  -18.96919 28.99955  1.000 95.47021  ? 126 THR A CG2   1 ? 
ATOM   1006 N N     . GLU A 1 133 ? 6.99051   -20.12414 26.37816  1.000 106.39676 ? 127 GLU A N     1 ? 
ATOM   1007 C CA    . GLU A 1 133 ? 6.28632   -20.97659 25.43088  1.000 97.04561  ? 127 GLU A CA    1 ? 
ATOM   1008 C C     . GLU A 1 133 ? 7.17419   -22.07024 24.85237  1.000 98.75061  ? 127 GLU A C     1 ? 
ATOM   1009 O O     . GLU A 1 133 ? 6.65768   -22.98355 24.19928  1.000 105.07082 ? 127 GLU A O     1 ? 
ATOM   1010 C CB    . GLU A 1 133 ? 5.69340   -20.12856 24.30235  1.000 101.20184 ? 127 GLU A CB    1 ? 
ATOM   1011 C CG    . GLU A 1 133 ? 4.88323   -18.93778 24.79563  1.000 99.10690  ? 127 GLU A CG    1 ? 
ATOM   1012 C CD    . GLU A 1 133 ? 4.36156   -18.07155 23.66571  1.000 95.06991  ? 127 GLU A CD    1 ? 
ATOM   1013 O OE1   . GLU A 1 133 ? 4.61365   -18.40803 22.48992  1.000 98.19349  ? 127 GLU A OE1   1 ? 
ATOM   1014 O OE2   . GLU A 1 133 ? 3.69713   -17.05379 23.95424  1.000 98.94341  ? 127 GLU A OE2   1 ? 
ATOM   1015 N N     . ASN A 1 134 ? 8.48695   -22.00308 25.07901  1.000 101.65053 ? 128 ASN A N     1 ? 
ATOM   1016 C CA    . ASN A 1 134 ? 9.41604   -23.04591 24.66803  1.000 104.87818 ? 128 ASN A CA    1 ? 
ATOM   1017 C C     . ASN A 1 134 ? 9.60420   -24.11571 25.74049  1.000 108.33945 ? 128 ASN A C     1 ? 
ATOM   1018 O O     . ASN A 1 134 ? 10.64643  -24.78173 25.76233  1.000 107.53904 ? 128 ASN A O     1 ? 
ATOM   1019 C CB    . ASN A 1 134 ? 10.76816  -22.43219 24.29360  1.000 111.38766 ? 128 ASN A CB    1 ? 
ATOM   1020 C CG    . ASN A 1 134 ? 10.62988  -21.20473 23.41111  1.000 117.81075 ? 128 ASN A CG    1 ? 
ATOM   1021 O OD1   . ASN A 1 134 ? 9.54257   -20.89329 22.92480  1.000 111.74506 ? 128 ASN A OD1   1 ? 
ATOM   1022 N ND2   . ASN A 1 134 ? 11.73628  -20.49978 23.20124  1.000 111.60008 ? 128 ASN A ND2   1 ? 
ATOM   1023 N N     . ASP A 1 135 ? 8.62019   -24.28536 26.62682  1.000 111.96904 ? 129 ASP A N     1 ? 
ATOM   1024 C CA    . ASP A 1 135 ? 8.63578   -25.27446 27.70545  1.000 114.38915 ? 129 ASP A CA    1 ? 
ATOM   1025 C C     . ASP A 1 135 ? 9.79270   -25.06121 28.67925  1.000 108.10015 ? 129 ASP A C     1 ? 
ATOM   1026 O O     . ASP A 1 135 ? 10.21341  -25.99874 29.36400  1.000 100.19897 ? 129 ASP A O     1 ? 
ATOM   1027 C CB    . ASP A 1 135 ? 8.66028   -26.70425 27.14972  1.000 121.15473 ? 129 ASP A CB    1 ? 
ATOM   1028 C CG    . ASP A 1 135 ? 7.27906   -27.33046 27.09606  1.000 125.58082 ? 129 ASP A CG    1 ? 
ATOM   1029 O OD1   . ASP A 1 135 ? 6.28861   -26.57432 27.01020  1.000 125.85420 ? 129 ASP A OD1   1 ? 
ATOM   1030 O OD2   . ASP A 1 135 ? 7.18323   -28.57549 27.14136  1.000 119.62447 ? 129 ASP A OD2   1 ? 
ATOM   1031 N N     . GLU A 1 136 ? 10.30639  -23.83712 28.75330  1.000 104.20594 ? 130 GLU A N     1 ? 
ATOM   1032 C CA    . GLU A 1 136 ? 11.37382  -23.46194 29.66841  1.000 109.22869 ? 130 GLU A CA    1 ? 
ATOM   1033 C C     . GLU A 1 136 ? 10.79626  -22.57257 30.75883  1.000 106.33364 ? 130 GLU A C     1 ? 
ATOM   1034 O O     . GLU A 1 136 ? 9.91780   -21.74671 30.49527  1.000 103.38143 ? 130 GLU A O     1 ? 
ATOM   1035 C CB    . GLU A 1 136 ? 12.48533  -22.71684 28.92372  1.000 109.08081 ? 130 GLU A CB    1 ? 
ATOM   1036 C CG    . GLU A 1 136 ? 13.82915  -22.61588 29.64840  1.000 111.71393 ? 130 GLU A CG    1 ? 
ATOM   1037 C CD    . GLU A 1 136 ? 14.08695  -23.76062 30.61859  1.000 122.08091 ? 130 GLU A CD    1 ? 
ATOM   1038 O OE1   . GLU A 1 136 ? 13.74632  -23.63982 31.81584  1.000 114.26141 ? 130 GLU A OE1   1 ? 
ATOM   1039 O OE2   . GLU A 1 136 ? 14.64449  -24.78743 30.17871  1.000 114.70081 ? 130 GLU A OE2   1 ? 
ATOM   1040 N N     . LYS A 1 137 ? 11.28340  -22.74008 31.98388  1.000 102.64218 ? 131 LYS A N     1 ? 
ATOM   1041 C CA    . LYS A 1 137 ? 10.83062  -21.89576 33.07548  1.000 102.77296 ? 131 LYS A CA    1 ? 
ATOM   1042 C C     . LYS A 1 137 ? 12.02840  -21.34134 33.83417  1.000 99.06819  ? 131 LYS A C     1 ? 
ATOM   1043 O O     . LYS A 1 137 ? 13.10542  -21.93973 33.86993  1.000 100.66496 ? 131 LYS A O     1 ? 
ATOM   1044 C CB    . LYS A 1 137 ? 9.84894   -22.64381 34.00577  1.000 99.73198  ? 131 LYS A CB    1 ? 
ATOM   1045 C CG    . LYS A 1 137 ? 10.30684  -23.95267 34.66903  1.000 99.00692  ? 131 LYS A CG    1 ? 
ATOM   1046 C CD    . LYS A 1 137 ? 11.22828  -23.71951 35.86214  1.000 105.37063 ? 131 LYS A CD    1 ? 
ATOM   1047 C CE    . LYS A 1 137 ? 11.30075  -24.94808 36.74689  1.000 114.75168 ? 131 LYS A CE    1 ? 
ATOM   1048 N NZ    . LYS A 1 137 ? 11.68008  -24.61362 38.14110  1.000 98.27230  ? 131 LYS A NZ    1 ? 
ATOM   1049 N N     . PHE A 1 138 ? 11.82878  -20.15705 34.40551  1.000 95.98021  ? 132 PHE A N     1 ? 
ATOM   1050 C CA    . PHE A 1 138 ? 12.83659  -19.47082 35.19527  1.000 97.57502  ? 132 PHE A CA    1 ? 
ATOM   1051 C C     . PHE A 1 138 ? 12.21640  -19.06494 36.52414  1.000 98.07889  ? 132 PHE A C     1 ? 
ATOM   1052 O O     . PHE A 1 138 ? 10.99617  -18.93407 36.64830  1.000 91.66190  ? 132 PHE A O     1 ? 
ATOM   1053 C CB    . PHE A 1 138 ? 13.39094  -18.22995 34.47096  1.000 94.00789  ? 132 PHE A CB    1 ? 
ATOM   1054 C CG    . PHE A 1 138 ? 14.02078  -18.52490 33.13106  1.000 91.84961  ? 132 PHE A CG    1 ? 
ATOM   1055 C CD1   . PHE A 1 138 ? 13.23839  -18.81523 32.02377  1.000 87.25579  ? 132 PHE A CD1   1 ? 
ATOM   1056 C CD2   . PHE A 1 138 ? 15.39902  -18.50508 32.98056  1.000 86.76071  ? 132 PHE A CD2   1 ? 
ATOM   1057 C CE1   . PHE A 1 138 ? 13.81661  -19.07873 30.79742  1.000 94.37619  ? 132 PHE A CE1   1 ? 
ATOM   1058 C CE2   . PHE A 1 138 ? 15.98301  -18.76822 31.75452  1.000 90.44252  ? 132 PHE A CE2   1 ? 
ATOM   1059 C CZ    . PHE A 1 138 ? 15.19007  -19.05574 30.66283  1.000 95.36099  ? 132 PHE A CZ    1 ? 
ATOM   1060 N N     . THR A 1 139 ? 13.06926  -18.86505 37.52248  1.000 98.74620  ? 133 THR A N     1 ? 
ATOM   1061 C CA    . THR A 1 139 ? 12.63190  -18.46312 38.85053  1.000 95.22990  ? 133 THR A CA    1 ? 
ATOM   1062 C C     . THR A 1 139 ? 13.16362  -17.07233 39.16588  1.000 87.80208  ? 133 THR A C     1 ? 
ATOM   1063 O O     . THR A 1 139 ? 14.30799  -16.74619 38.83573  1.000 88.75749  ? 133 THR A O     1 ? 
ATOM   1064 C CB    . THR A 1 139 ? 13.10310  -19.46043 39.91426  1.000 99.17723  ? 133 THR A CB    1 ? 
ATOM   1065 O OG1   . THR A 1 139 ? 14.50076  -19.27110 40.16441  1.000 86.68882  ? 133 THR A OG1   1 ? 
ATOM   1066 C CG2   . THR A 1 139 ? 12.86655  -20.89030 39.44735  1.000 98.36635  ? 133 THR A CG2   1 ? 
ATOM   1067 N N     . ALA A 1 140 ? 12.32975  -16.25320 39.80359  1.000 85.06091  ? 134 ALA A N     1 ? 
ATOM   1068 C CA    . ALA A 1 140 ? 12.73406  -14.90178 40.16276  1.000 84.23269  ? 134 ALA A CA    1 ? 
ATOM   1069 C C     . ALA A 1 140 ? 11.84051  -14.38727 41.27935  1.000 83.19968  ? 134 ALA A C     1 ? 
ATOM   1070 O O     . ALA A 1 140 ? 10.63150  -14.63153 41.27541  1.000 80.39779  ? 134 ALA A O     1 ? 
ATOM   1071 C CB    . ALA A 1 140 ? 12.67150  -13.95298 38.96078  1.000 88.63276  ? 134 ALA A CB    1 ? 
ATOM   1072 N N     . ARG A 1 141 ? 12.44896  -13.66832 42.22599  1.000 82.25858  ? 135 ARG A N     1 ? 
ATOM   1073 C CA    . ARG A 1 141 ? 11.69168  -13.09298 43.33328  1.000 83.86016  ? 135 ARG A CA    1 ? 
ATOM   1074 C C     . ARG A 1 141 ? 10.64080  -12.11188 42.83042  1.000 86.68399  ? 135 ARG A C     1 ? 
ATOM   1075 O O     . ARG A 1 141 ? 9.46228   -12.20414 43.19259  1.000 80.14959  ? 135 ARG A O     1 ? 
ATOM   1076 C CB    . ARG A 1 141 ? 12.64226  -12.40352 44.31234  1.000 82.96329  ? 135 ARG A CB    1 ? 
ATOM   1077 C CG    . ARG A 1 141 ? 11.96839  -11.88124 45.57067  1.000 86.47209  ? 135 ARG A CG    1 ? 
ATOM   1078 C CD    . ARG A 1 141 ? 12.88681  -11.99820 46.77513  1.000 102.40659 ? 135 ARG A CD    1 ? 
ATOM   1079 N NE    . ARG A 1 141 ? 13.08224  -13.38489 47.18020  1.000 112.94724 ? 135 ARG A NE    1 ? 
ATOM   1080 C CZ    . ARG A 1 141 ? 14.17814  -13.84626 47.76705  1.000 116.19292 ? 135 ARG A CZ    1 ? 
ATOM   1081 N NH1   . ARG A 1 141 ? 15.20500  -13.05539 48.03355  1.000 107.39075 ? 135 ARG A NH1   1 ? 
ATOM   1082 N NH2   . ARG A 1 141 ? 14.24593  -15.13364 48.09406  1.000 112.53097 ? 135 ARG A NH2   1 ? 
ATOM   1083 N N     . PHE A 1 142 ? 11.04988  -11.16515 41.99335  1.000 86.31299  ? 136 PHE A N     1 ? 
ATOM   1084 C CA    . PHE A 1 142 ? 10.16646  -10.12710 41.49001  1.000 86.71079  ? 136 PHE A CA    1 ? 
ATOM   1085 C C     . PHE A 1 142 ? 9.88778   -10.34459 40.00973  1.000 84.20256  ? 136 PHE A C     1 ? 
ATOM   1086 O O     . PHE A 1 142 ? 10.73247  -10.85277 39.26742  1.000 82.48379  ? 136 PHE A O     1 ? 
ATOM   1087 C CB    . PHE A 1 142 ? 10.77283  -8.73915  41.71215  1.000 86.01940  ? 136 PHE A CB    1 ? 
ATOM   1088 C CG    . PHE A 1 142 ? 10.91192  -8.36960  43.15938  1.000 84.27188  ? 136 PHE A CG    1 ? 
ATOM   1089 C CD1   . PHE A 1 142 ? 9.79086   -8.21149  43.95689  1.000 80.88655  ? 136 PHE A CD1   1 ? 
ATOM   1090 C CD2   . PHE A 1 142 ? 12.16223  -8.19631  43.72724  1.000 78.56483  ? 136 PHE A CD2   1 ? 
ATOM   1091 C CE1   . PHE A 1 142 ? 9.91387   -7.87599  45.29105  1.000 83.47872  ? 136 PHE A CE1   1 ? 
ATOM   1092 C CE2   . PHE A 1 142 ? 12.29065  -7.86239  45.05929  1.000 81.57589  ? 136 PHE A CE2   1 ? 
ATOM   1093 C CZ    . PHE A 1 142 ? 11.16592  -7.70195  45.84323  1.000 84.04389  ? 136 PHE A CZ    1 ? 
ATOM   1094 N N     . LEU A 1 143 ? 8.68492   -9.96174  39.58975  1.000 81.51517  ? 137 LEU A N     1 ? 
ATOM   1095 C CA    . LEU A 1 143 ? 8.26486   -10.07864 38.19803  1.000 85.13603  ? 137 LEU A CA    1 ? 
ATOM   1096 C C     . LEU A 1 143 ? 7.63973   -8.75233  37.78834  1.000 86.48026  ? 137 LEU A C     1 ? 
ATOM   1097 O O     . LEU A 1 143 ? 6.52234   -8.43272  38.20798  1.000 86.92348  ? 137 LEU A O     1 ? 
ATOM   1098 C CB    . LEU A 1 143 ? 7.28648   -11.24003 38.01016  1.000 81.67981  ? 137 LEU A CB    1 ? 
ATOM   1099 C CG    . LEU A 1 143 ? 6.37856   -11.21049 36.78042  1.000 81.08700  ? 137 LEU A CG    1 ? 
ATOM   1100 C CD1   . LEU A 1 143 ? 7.13284   -11.75345 35.58303  1.000 80.80765  ? 137 LEU A CD1   1 ? 
ATOM   1101 C CD2   . LEU A 1 143 ? 5.10682   -12.00748 37.02294  1.000 66.12327  ? 137 LEU A CD2   1 ? 
ATOM   1102 N N     . ILE A 1 144 ? 8.36798   -7.97081  36.99564  1.000 83.08022  ? 138 ILE A N     1 ? 
ATOM   1103 C CA    . ILE A 1 144 ? 7.85872   -6.70850  36.47238  1.000 84.85014  ? 138 ILE A CA    1 ? 
ATOM   1104 C C     . ILE A 1 144 ? 7.23275   -6.96410  35.11063  1.000 81.60765  ? 138 ILE A C     1 ? 
ATOM   1105 O O     . ILE A 1 144 ? 7.79781   -7.67146  34.26725  1.000 76.17861  ? 138 ILE A O     1 ? 
ATOM   1106 C CB    . ILE A 1 144 ? 8.96544   -5.63871  36.38771  1.000 73.06062  ? 138 ILE A CB    1 ? 
ATOM   1107 C CG1   . ILE A 1 144 ? 10.01596  -5.81612  37.49094  1.000 82.30988  ? 138 ILE A CG1   1 ? 
ATOM   1108 C CG2   . ILE A 1 144 ? 8.35764   -4.25140  36.46692  1.000 82.24471  ? 138 ILE A CG2   1 ? 
ATOM   1109 C CD1   . ILE A 1 144 ? 9.47055   -5.74572  38.91200  1.000 85.37316  ? 138 ILE A CD1   1 ? 
ATOM   1110 N N     . THR A 1 145 ? 6.05586   -6.38441  34.89592  1.000 77.83858  ? 139 THR A N     1 ? 
ATOM   1111 C CA    . THR A 1 145 ? 5.23159   -6.65752  33.72406  1.000 67.41594  ? 139 THR A CA    1 ? 
ATOM   1112 C C     . THR A 1 145 ? 5.05395   -5.36997  32.92939  1.000 69.74381  ? 139 THR A C     1 ? 
ATOM   1113 O O     . THR A 1 145 ? 4.36110   -4.44884  33.37577  1.000 80.18451  ? 139 THR A O     1 ? 
ATOM   1114 C CB    . THR A 1 145 ? 3.88211   -7.23413  34.14480  1.000 77.94781  ? 139 THR A CB    1 ? 
ATOM   1115 O OG1   . THR A 1 145 ? 2.99995   -6.16547  34.50731  1.000 88.44778  ? 139 THR A OG1   1 ? 
ATOM   1116 C CG2   . THR A 1 145 ? 4.04905   -8.17462  35.32725  1.000 83.00882  ? 139 THR A CG2   1 ? 
ATOM   1117 N N     . ALA A 1 146 ? 5.67006   -5.30984  31.75089  1.000 76.38074  ? 140 ALA A N     1 ? 
ATOM   1118 C CA    . ALA A 1 146 ? 5.60242   -4.14423  30.86925  1.000 77.43883  ? 140 ALA A CA    1 ? 
ATOM   1119 C C     . ALA A 1 146 ? 4.99625   -4.59048  29.54150  1.000 77.73501  ? 140 ALA A C     1 ? 
ATOM   1120 O O     . ALA A 1 146 ? 5.70340   -4.77947  28.54931  1.000 71.71553  ? 140 ALA A O     1 ? 
ATOM   1121 C CB    . ALA A 1 146 ? 6.98880   -3.51697  30.68358  1.000 66.74846  ? 140 ALA A CB    1 ? 
ATOM   1122 N N     . LEU A 1 147 ? 3.67227   -4.75356  29.52845  1.000 80.81501  ? 141 LEU A N     1 ? 
ATOM   1123 C CA    . LEU A 1 147 ? 2.95332   -5.21234  28.34659  1.000 78.78375  ? 141 LEU A CA    1 ? 
ATOM   1124 C C     . LEU A 1 147 ? 2.31416   -4.08451  27.55321  1.000 83.81737  ? 141 LEU A C     1 ? 
ATOM   1125 O O     . LEU A 1 147 ? 1.78734   -4.33834  26.46477  1.000 83.03469  ? 141 LEU A O     1 ? 
ATOM   1126 C CB    . LEU A 1 147 ? 1.86459   -6.22493  28.72796  1.000 82.79116  ? 141 LEU A CB    1 ? 
ATOM   1127 C CG    . LEU A 1 147 ? 2.30073   -7.47077  29.50028  1.000 84.17765  ? 141 LEU A CG    1 ? 
ATOM   1128 C CD1   . LEU A 1 147 ? 3.64965   -7.94327  29.00160  1.000 75.93355  ? 141 LEU A CD1   1 ? 
ATOM   1129 C CD2   . LEU A 1 147 ? 2.32704   -7.25465  30.98902  1.000 81.66666  ? 141 LEU A CD2   1 ? 
ATOM   1130 N N     . GLY A 1 148 ? 2.34320   -2.85889  28.06348  1.000 89.09258  ? 142 GLY A N     1 ? 
ATOM   1131 C CA    . GLY A 1 148 ? 1.78852   -1.73285  27.35670  1.000 92.99658  ? 142 GLY A CA    1 ? 
ATOM   1132 C C     . GLY A 1 148 ? 0.27569   -1.74885  27.31383  1.000 98.62424  ? 142 GLY A C     1 ? 
ATOM   1133 O O     . GLY A 1 148 ? -0.38313  -2.63448  27.86859  1.000 98.54302  ? 142 GLY A O     1 ? 
ATOM   1134 N N     . PRO A 1 149 ? -0.30334  -0.75939  26.64055  1.000 103.94797 ? 143 PRO A N     1 ? 
ATOM   1135 C CA    . PRO A 1 149 ? -1.76531  -0.63485  26.61667  1.000 107.58871 ? 143 PRO A CA    1 ? 
ATOM   1136 C C     . PRO A 1 149 ? -2.42725  -1.44620  25.51317  1.000 106.44636 ? 143 PRO A C     1 ? 
ATOM   1137 O O     . PRO A 1 149 ? -3.54605  -1.93916  25.68884  1.000 107.81677 ? 143 PRO A O     1 ? 
ATOM   1138 C CB    . PRO A 1 149 ? -1.98121  0.86994   26.41362  1.000 109.79183 ? 143 PRO A CB    1 ? 
ATOM   1139 C CG    . PRO A 1 149 ? -0.70958  1.37509   25.77356  1.000 98.84579  ? 143 PRO A CG    1 ? 
ATOM   1140 C CD    . PRO A 1 149 ? 0.36536   0.32879   25.90992  1.000 98.91728  ? 143 PRO A CD    1 ? 
ATOM   1141 N N     . LEU A 1 150 ? -1.75465  -1.58971  24.37509  1.000 109.64505 ? 144 LEU A N     1 ? 
ATOM   1142 C CA    . LEU A 1 150 ? -2.32505  -2.33680  23.26333  1.000 114.84780 ? 144 LEU A CA    1 ? 
ATOM   1143 C C     . LEU A 1 150 ? -2.27281  -3.83386  23.54380  1.000 113.63490 ? 144 LEU A C     1 ? 
ATOM   1144 O O     . LEU A 1 150 ? -1.28229  -4.35120  24.06769  1.000 109.65999 ? 144 LEU A O     1 ? 
ATOM   1145 C CB    . LEU A 1 150 ? -1.57928  -2.01318  21.96888  1.000 113.46361 ? 144 LEU A CB    1 ? 
ATOM   1146 C CG    . LEU A 1 150 ? -1.63516  -0.56065  21.48684  1.000 111.97452 ? 144 LEU A CG    1 ? 
ATOM   1147 C CD1   . LEU A 1 150 ? -1.24896  -0.46825  20.01988  1.000 103.22483 ? 144 LEU A CD1   1 ? 
ATOM   1148 C CD2   . LEU A 1 150 ? -3.01599  0.03904   21.71543  1.000 107.02728 ? 144 LEU A CD2   1 ? 
ATOM   1149 N N     . ALA A 1 151 ? -3.35300  -4.53133  23.19262  1.000 111.24226 ? 145 ALA A N     1 ? 
ATOM   1150 C CA    . ALA A 1 151 ? -3.44237  -5.96675  23.43082  1.000 111.85052 ? 145 ALA A CA    1 ? 
ATOM   1151 C C     . ALA A 1 151 ? -3.58831  -6.73292  22.12227  1.000 114.89777 ? 145 ALA A C     1 ? 
ATOM   1152 O O     . ALA A 1 151 ? -2.87365  -6.46006  21.15230  1.000 112.55869 ? 145 ALA A O     1 ? 
ATOM   1153 C CB    . ALA A 1 151 ? -4.61303  -6.28298  24.36364  1.000 103.93901 ? 145 ALA A CB    1 ? 
ATOM   1154 N N     . ALA A 1 152 ? -4.51067  -7.69721  22.08852  1.000 119.50672 ? 146 ALA A N     1 ? 
ATOM   1155 C CA    . ALA A 1 152 ? -4.73253  -8.48662  20.88475  1.000 120.32940 ? 146 ALA A CA    1 ? 
ATOM   1156 C C     . ALA A 1 152 ? -5.56039  -7.68973  19.87837  1.000 124.35088 ? 146 ALA A C     1 ? 
ATOM   1157 O O     . ALA A 1 152 ? -6.46201  -6.94390  20.26668  1.000 121.72398 ? 146 ALA A O     1 ? 
ATOM   1158 C CB    . ALA A 1 152 ? -5.44258  -9.79575  21.22249  1.000 104.61838 ? 146 ALA A CB    1 ? 
ATOM   1159 N N     . PRO A 1 153 ? -5.27478  -7.82884  18.58114  1.000 120.87456 ? 147 PRO A N     1 ? 
ATOM   1160 C CA    . PRO A 1 153 ? -5.99474  -7.03841  17.56968  1.000 113.67597 ? 147 PRO A CA    1 ? 
ATOM   1161 C C     . PRO A 1 153 ? -7.44512  -7.48296  17.44555  1.000 113.71367 ? 147 PRO A C     1 ? 
ATOM   1162 O O     . PRO A 1 153 ? -7.73021  -8.62839  17.09007  1.000 117.71764 ? 147 PRO A O     1 ? 
ATOM   1163 C CB    . PRO A 1 153 ? -5.20524  -7.31256  16.28397  1.000 108.46199 ? 147 PRO A CB    1 ? 
ATOM   1164 C CG    . PRO A 1 153 ? -4.56589  -8.63987  16.51832  1.000 109.97302 ? 147 PRO A CG    1 ? 
ATOM   1165 C CD    . PRO A 1 153 ? -4.23050  -8.67547  17.98141  1.000 116.16247 ? 147 PRO A CD    1 ? 
ATOM   1166 N N     . ASN A 1 154 ? -8.36330  -6.56451  17.73961  1.000 114.08137 ? 148 ASN A N     1 ? 
ATOM   1167 C CA    . ASN A 1 154 ? -9.79408  -6.82559  17.59914  1.000 113.82023 ? 148 ASN A CA    1 ? 
ATOM   1168 C C     . ASN A 1 154 ? -10.14712 -6.75647  16.11912  1.000 113.12970 ? 148 ASN A C     1 ? 
ATOM   1169 O O     . ASN A 1 154 ? -10.36667 -5.67623  15.56645  1.000 107.46584 ? 148 ASN A O     1 ? 
ATOM   1170 C CB    . ASN A 1 154 ? -10.60906 -5.82980  18.41787  1.000 109.85894 ? 148 ASN A CB    1 ? 
ATOM   1171 C CG    . ASN A 1 154 ? -12.06466 -5.76725  17.98551  1.000 115.25435 ? 148 ASN A CG    1 ? 
ATOM   1172 O OD1   . ASN A 1 154 ? -12.49366 -4.80585  17.34637  1.000 109.87402 ? 148 ASN A OD1   1 ? 
ATOM   1173 N ND2   . ASN A 1 154 ? -12.82987 -6.79680  18.32961  1.000 118.59618 ? 148 ASN A ND2   1 ? 
ATOM   1174 N N     . LEU A 1 155 ? -10.17964 -7.90712  15.47084  1.000 116.99760 ? 149 LEU A N     1 ? 
ATOM   1175 C CA    . LEU A 1 155 ? -10.59922 -7.96648  14.08145  1.000 110.30415 ? 149 LEU A CA    1 ? 
ATOM   1176 C C     . LEU A 1 155 ? -12.11877 -8.07602  13.99765  1.000 111.33274 ? 149 LEU A C     1 ? 
ATOM   1177 O O     . LEU A 1 155 ? -12.75831 -8.62022  14.90421  1.000 110.45416 ? 149 LEU A O     1 ? 
ATOM   1178 C CB    . LEU A 1 155 ? -9.95164  -9.15942  13.38167  1.000 113.21770 ? 149 LEU A CB    1 ? 
ATOM   1179 C CG    . LEU A 1 155 ? -8.43554  -9.28699  13.55250  1.000 118.14859 ? 149 LEU A CG    1 ? 
ATOM   1180 C CD1   . LEU A 1 155 ? -8.08051  -10.55080 14.32354  1.000 109.87826 ? 149 LEU A CD1   1 ? 
ATOM   1181 C CD2   . LEU A 1 155 ? -7.73383  -9.25966  12.20226  1.000 113.70663 ? 149 LEU A CD2   1 ? 
ATOM   1182 N N     . PRO A 1 156 ? -12.73247 -7.56420  12.93339  1.000 111.93494 ? 150 PRO A N     1 ? 
ATOM   1183 C CA    . PRO A 1 156 ? -14.19560 -7.59981  12.84873  1.000 115.32747 ? 150 PRO A CA    1 ? 
ATOM   1184 C C     . PRO A 1 156 ? -14.70996 -9.01917  12.67166  1.000 116.58073 ? 150 PRO A C     1 ? 
ATOM   1185 O O     . PRO A 1 156 ? -14.00029 -9.92358  12.22676  1.000 110.12773 ? 150 PRO A O     1 ? 
ATOM   1186 C CB    . PRO A 1 156 ? -14.51930 -6.73588  11.62429  1.000 108.42850 ? 150 PRO A CB    1 ? 
ATOM   1187 C CG    . PRO A 1 156 ? -13.25799 -6.60659  10.86191  1.000 108.87377 ? 150 PRO A CG    1 ? 
ATOM   1188 C CD    . PRO A 1 156 ? -12.10215 -7.01470  11.71992  1.000 102.92101 ? 150 PRO A CD    1 ? 
ATOM   1189 N N     . LYS A 1 157 ? -15.97354 -9.20549  13.04953  1.000 117.11165 ? 151 LYS A N     1 ? 
ATOM   1190 C CA    . LYS A 1 157 ? -16.65796 -10.48719 12.89206  1.000 114.13112 ? 151 LYS A CA    1 ? 
ATOM   1191 C C     . LYS A 1 157 ? -17.61520 -10.36068 11.70572  1.000 105.01559 ? 151 LYS A C     1 ? 
ATOM   1192 O O     . LYS A 1 157 ? -18.80070 -10.05417 11.83445  1.000 113.88482 ? 151 LYS A O     1 ? 
ATOM   1193 C CB    . LYS A 1 157 ? -17.34472 -10.91209 14.20434  1.000 112.15265 ? 151 LYS A CB    1 ? 
ATOM   1194 C CG    . LYS A 1 157 ? -18.56244 -10.10508 14.70112  1.000 115.98614 ? 151 LYS A CG    1 ? 
ATOM   1195 C CD    . LYS A 1 157 ? -18.27131 -8.63158  14.91658  1.000 108.65468 ? 151 LYS A CD    1 ? 
ATOM   1196 C CE    . LYS A 1 157 ? -19.22490 -8.02448  15.92730  1.000 120.72824 ? 151 LYS A CE    1 ? 
ATOM   1197 N NZ    . LYS A 1 157 ? -19.12276 -6.54380  15.94772  1.000 126.72897 ? 151 LYS A NZ    1 ? 
ATOM   1198 N N     . ILE A 1 158 ? -17.06794 -10.59782 10.51742  1.000 92.09152  ? 152 ILE A N     1 ? 
ATOM   1199 C CA    . ILE A 1 158 ? -17.78061 -10.39868 9.26188   1.000 90.98912  ? 152 ILE A CA    1 ? 
ATOM   1200 C C     . ILE A 1 158 ? -17.86747 -11.73272 8.53217   1.000 97.79641  ? 152 ILE A C     1 ? 
ATOM   1201 O O     . ILE A 1 158 ? -16.85150 -12.41358 8.35000   1.000 104.54356 ? 152 ILE A O     1 ? 
ATOM   1202 C CB    . ILE A 1 158 ? -17.08943 -9.33705  8.38456   1.000 94.07772  ? 152 ILE A CB    1 ? 
ATOM   1203 C CG1   . ILE A 1 158 ? -17.27868 -7.93976  8.98184   1.000 94.69312  ? 152 ILE A CG1   1 ? 
ATOM   1204 C CG2   . ILE A 1 158 ? -17.62339 -9.38055  6.96059   1.000 85.99275  ? 152 ILE A CG2   1 ? 
ATOM   1205 C CD1   . ILE A 1 158 ? -18.70690 -7.44369  8.93620   1.000 89.65159  ? 152 ILE A CD1   1 ? 
ATOM   1206 N N     . LYS A 1 159 ? -19.08119 -12.10596 8.12761   1.000 91.51801  ? 153 LYS A N     1 ? 
ATOM   1207 C CA    . LYS A 1 159 ? -19.27199 -13.27650 7.27931   1.000 90.78451  ? 153 LYS A CA    1 ? 
ATOM   1208 C C     . LYS A 1 159 ? -18.48776 -13.09738 5.98318   1.000 93.75680  ? 153 LYS A C     1 ? 
ATOM   1209 O O     . LYS A 1 159 ? -18.58501 -12.06032 5.32284   1.000 96.60771  ? 153 LYS A O     1 ? 
ATOM   1210 C CB    . LYS A 1 159 ? -20.77071 -13.46673 6.99969   1.000 95.49157  ? 153 LYS A CB    1 ? 
ATOM   1211 C CG    . LYS A 1 159 ? -21.19690 -14.38856 5.83180   1.000 102.23455 ? 153 LYS A CG    1 ? 
ATOM   1212 C CD    . LYS A 1 159 ? -20.30413 -15.60456 5.59562   1.000 105.46580 ? 153 LYS A CD    1 ? 
ATOM   1213 C CE    . LYS A 1 159 ? -20.75504 -16.40803 4.38474   1.000 94.88478  ? 153 LYS A CE    1 ? 
ATOM   1214 N NZ    . LYS A 1 159 ? -20.09497 -17.74007 4.29301   1.000 90.87458  ? 153 LYS A NZ    1 ? 
ATOM   1215 N N     . GLY A 1 160 ? -17.70338 -14.11017 5.62594   1.000 88.83340  ? 154 GLY A N     1 ? 
ATOM   1216 C CA    . GLY A 1 160 ? -16.94454 -14.09943 4.39554   1.000 93.11116  ? 154 GLY A CA    1 ? 
ATOM   1217 C C     . GLY A 1 160 ? -15.50556 -13.66670 4.53262   1.000 94.81770  ? 154 GLY A C     1 ? 
ATOM   1218 O O     . GLY A 1 160 ? -14.82691 -13.51134 3.51173   1.000 96.93765  ? 154 GLY A O     1 ? 
ATOM   1219 N N     . ILE A 1 161 ? -15.01952 -13.46954 5.75952   1.000 96.49017  ? 155 ILE A N     1 ? 
ATOM   1220 C CA    . ILE A 1 161 ? -13.65524 -12.99156 5.96444   1.000 99.01949  ? 155 ILE A CA    1 ? 
ATOM   1221 C C     . ILE A 1 161 ? -12.64981 -13.96163 5.35647   1.000 100.32795 ? 155 ILE A C     1 ? 
ATOM   1222 O O     . ILE A 1 161 ? -11.63386 -13.54974 4.78251   1.000 100.54778 ? 155 ILE A O     1 ? 
ATOM   1223 C CB    . ILE A 1 161 ? -13.40210 -12.76507 7.46725   1.000 104.01247 ? 155 ILE A CB    1 ? 
ATOM   1224 C CG1   . ILE A 1 161 ? -13.80867 -11.34399 7.85967   1.000 97.84052  ? 155 ILE A CG1   1 ? 
ATOM   1225 C CG2   . ILE A 1 161 ? -11.94496 -13.03161 7.83155   1.000 95.41873  ? 155 ILE A CG2   1 ? 
ATOM   1226 C CD1   . ILE A 1 161 ? -13.62182 -11.04455 9.31917   1.000 104.03451 ? 155 ILE A CD1   1 ? 
ATOM   1227 N N     . GLU A 1 162 ? -12.93036 -15.26285 5.44373   1.000 102.48129 ? 156 GLU A N     1 ? 
ATOM   1228 C CA    . GLU A 1 162 ? -11.98652 -16.26323 4.96142   1.000 102.39892 ? 156 GLU A CA    1 ? 
ATOM   1229 C C     . GLU A 1 162 ? -11.96701 -16.37400 3.44150   1.000 98.73052  ? 156 GLU A C     1 ? 
ATOM   1230 O O     . GLU A 1 162 ? -10.99464 -16.89671 2.88685   1.000 93.87454  ? 156 GLU A O     1 ? 
ATOM   1231 C CB    . GLU A 1 162 ? -12.31293 -17.62730 5.57442   1.000 104.29215 ? 156 GLU A CB    1 ? 
ATOM   1232 C CG    . GLU A 1 162 ? -13.53058 -18.31612 4.96708   1.000 106.44874 ? 156 GLU A CG    1 ? 
ATOM   1233 C CD    . GLU A 1 162 ? -14.84998 -17.73084 5.44149   1.000 115.81204 ? 156 GLU A CD    1 ? 
ATOM   1234 O OE1   . GLU A 1 162 ? -14.83304 -16.76253 6.23021   1.000 115.26614 ? 156 GLU A OE1   1 ? 
ATOM   1235 O OE2   . GLU A 1 162 ? -15.90954 -18.24063 5.01985   1.000 121.43659 ? 156 GLU A OE2   1 ? 
ATOM   1236 N N     . THR A 1 163 ? -13.00229 -15.89294 2.75426   1.000 95.59185  ? 157 THR A N     1 ? 
ATOM   1237 C CA    . THR A 1 163 ? -13.11214 -16.10373 1.31685   1.000 94.07673  ? 157 THR A CA    1 ? 
ATOM   1238 C C     . THR A 1 163 ? -12.45092 -15.00891 0.48716   1.000 93.11253  ? 157 THR A C     1 ? 
ATOM   1239 O O     . THR A 1 163 ? -12.30967 -15.18340 -0.72766  1.000 101.82324 ? 157 THR A O     1 ? 
ATOM   1240 C CB    . THR A 1 163 ? -14.58697 -16.24247 0.91148   1.000 95.04701  ? 157 THR A CB    1 ? 
ATOM   1241 O OG1   . THR A 1 163 ? -14.68469 -17.01665 -0.29123  1.000 108.63850 ? 157 THR A OG1   1 ? 
ATOM   1242 C CG2   . THR A 1 163 ? -15.21917 -14.88329 0.68566   1.000 76.28747  ? 157 THR A CG2   1 ? 
ATOM   1243 N N     . PHE A 1 164 ? -12.03048 -13.90362 1.10177   1.000 95.37430  ? 158 PHE A N     1 ? 
ATOM   1244 C CA    . PHE A 1 164 ? -11.35213 -12.84600 0.36027   1.000 82.69608  ? 158 PHE A CA    1 ? 
ATOM   1245 C C     . PHE A 1 164 ? -10.03996 -13.36190 -0.21609  1.000 79.47818  ? 158 PHE A C     1 ? 
ATOM   1246 O O     . PHE A 1 164 ? -9.15568  -13.80200 0.52503   1.000 81.66070  ? 158 PHE A O     1 ? 
ATOM   1247 C CB    . PHE A 1 164 ? -11.09640 -11.64126 1.26560   1.000 82.49772  ? 158 PHE A CB    1 ? 
ATOM   1248 C CG    . PHE A 1 164 ? -10.71592 -10.39145 0.51867   1.000 78.33613  ? 158 PHE A CG    1 ? 
ATOM   1249 C CD1   . PHE A 1 164 ? -11.53958 -9.88285  -0.47284  1.000 65.53741  ? 158 PHE A CD1   1 ? 
ATOM   1250 C CD2   . PHE A 1 164 ? -9.53191  -9.72937  0.80364   1.000 68.73436  ? 158 PHE A CD2   1 ? 
ATOM   1251 C CE1   . PHE A 1 164 ? -11.19319 -8.73493  -1.16236  1.000 66.40954  ? 158 PHE A CE1   1 ? 
ATOM   1252 C CE2   . PHE A 1 164 ? -9.17986  -8.58106  0.11693   1.000 56.72199  ? 158 PHE A CE2   1 ? 
ATOM   1253 C CZ    . PHE A 1 164 ? -10.01179 -8.08387  -0.86713  1.000 67.64671  ? 158 PHE A CZ    1 ? 
ATOM   1254 N N     . LYS A 1 165 ? -9.91516  -13.30679 -1.54100  1.000 79.31247  ? 159 LYS A N     1 ? 
ATOM   1255 C CA    . LYS A 1 165 ? -8.71526  -13.77193 -2.22225  1.000 80.82168  ? 159 LYS A CA    1 ? 
ATOM   1256 C C     . LYS A 1 165 ? -7.66132  -12.68570 -2.38884  1.000 78.15636  ? 159 LYS A C     1 ? 
ATOM   1257 O O     . LYS A 1 165 ? -6.55314  -12.98702 -2.84494  1.000 92.24521  ? 159 LYS A O     1 ? 
ATOM   1258 C CB    . LYS A 1 165 ? -9.07623  -14.34297 -3.59836  1.000 83.10330  ? 159 LYS A CB    1 ? 
ATOM   1259 C CG    . LYS A 1 165 ? -9.32621  -15.84110 -3.59956  1.000 95.61485  ? 159 LYS A CG    1 ? 
ATOM   1260 C CD    . LYS A 1 165 ? -9.80651  -16.32275 -4.95693  1.000 104.07299 ? 159 LYS A CD    1 ? 
ATOM   1261 C CE    . LYS A 1 165 ? -8.63998  -16.74730 -5.83322  1.000 106.43918 ? 159 LYS A CE    1 ? 
ATOM   1262 N NZ    . LYS A 1 165 ? -9.08626  -17.59102 -6.97500  1.000 102.78938 ? 159 LYS A NZ    1 ? 
ATOM   1263 N N     . GLY A 1 166 ? -7.97272  -11.44069 -2.03299  1.000 70.19714  ? 160 GLY A N     1 ? 
ATOM   1264 C CA    . GLY A 1 166 ? -7.03070  -10.34817 -2.14021  1.000 64.45725  ? 160 GLY A CA    1 ? 
ATOM   1265 C C     . GLY A 1 166 ? -6.21217  -10.17067 -0.87499  1.000 68.36807  ? 160 GLY A C     1 ? 
ATOM   1266 O O     . GLY A 1 166 ? -6.28111  -10.95924 0.06809   1.000 72.45512  ? 160 GLY A O     1 ? 
ATOM   1267 N N     . GLU A 1 167 ? -5.42102  -9.10013  -0.86657  1.000 69.11641  ? 161 GLU A N     1 ? 
ATOM   1268 C CA    . GLU A 1 167 ? -4.55918  -8.81836  0.27376   1.000 69.32658  ? 161 GLU A CA    1 ? 
ATOM   1269 C C     . GLU A 1 167 ? -5.39281  -8.42493  1.48720   1.000 68.98998  ? 161 GLU A C     1 ? 
ATOM   1270 O O     . GLU A 1 167 ? -6.28176  -7.57231  1.39799   1.000 65.83615  ? 161 GLU A O     1 ? 
ATOM   1271 C CB    . GLU A 1 167 ? -3.56363  -7.71146  -0.07081  1.000 63.86523  ? 161 GLU A CB    1 ? 
ATOM   1272 C CG    . GLU A 1 167 ? -2.73455  -7.98825  -1.31462  1.000 68.56799  ? 161 GLU A CG    1 ? 
ATOM   1273 C CD    . GLU A 1 167 ? -1.98130  -6.76461  -1.79737  1.000 77.63900  ? 161 GLU A CD    1 ? 
ATOM   1274 O OE1   . GLU A 1 167 ? -0.86410  -6.51673  -1.29626  1.000 79.82556  ? 161 GLU A OE1   1 ? 
ATOM   1275 O OE2   . GLU A 1 167 ? -2.50559  -6.05148  -2.67832  1.000 62.21410  ? 161 GLU A OE2   1 ? 
ATOM   1276 N N     . LEU A 1 168 ? -5.10074  -9.05263  2.62393   1.000 69.00116  ? 162 LEU A N     1 ? 
ATOM   1277 C CA    . LEU A 1 168 ? -5.81175  -8.81121  3.87318   1.000 71.16200  ? 162 LEU A CA    1 ? 
ATOM   1278 C C     . LEU A 1 168 ? -4.78517  -8.47524  4.94235   1.000 71.11579  ? 162 LEU A C     1 ? 
ATOM   1279 O O     . LEU A 1 168 ? -3.94007  -9.31217  5.27628   1.000 78.79364  ? 162 LEU A O     1 ? 
ATOM   1280 C CB    . LEU A 1 168 ? -6.63551  -10.03726 4.27858   1.000 69.07812  ? 162 LEU A CB    1 ? 
ATOM   1281 C CG    . LEU A 1 168 ? -7.92923  -9.86974  5.07967   1.000 70.29551  ? 162 LEU A CG    1 ? 
ATOM   1282 C CD1   . LEU A 1 168 ? -8.59166  -11.22762 5.23558   1.000 75.98213  ? 162 LEU A CD1   1 ? 
ATOM   1283 C CD2   . LEU A 1 168 ? -7.69190  -9.22914  6.44151   1.000 77.85110  ? 162 LEU A CD2   1 ? 
ATOM   1284 N N     . HIS A 1 169 ? -4.85568  -7.25856  5.47714   1.000 60.96796  ? 163 HIS A N     1 ? 
ATOM   1285 C CA    . HIS A 1 169 ? -3.89820  -6.81186  6.47947   1.000 68.03095  ? 163 HIS A CA    1 ? 
ATOM   1286 C C     . HIS A 1 169 ? -4.61987  -6.10056  7.61047   1.000 65.16026  ? 163 HIS A C     1 ? 
ATOM   1287 O O     . HIS A 1 169 ? -5.39965  -5.17491  7.36787   1.000 71.38791  ? 163 HIS A O     1 ? 
ATOM   1288 C CB    . HIS A 1 169 ? -2.84995  -5.86931  5.87409   1.000 65.33765  ? 163 HIS A CB    1 ? 
ATOM   1289 C CG    . HIS A 1 169 ? -2.21600  -6.38852  4.62272   1.000 73.26167  ? 163 HIS A CG    1 ? 
ATOM   1290 N ND1   . HIS A 1 169 ? -1.71949  -7.66981  4.51543   1.000 78.39663  ? 163 HIS A ND1   1 ? 
ATOM   1291 C CD2   . HIS A 1 169 ? -1.99166  -5.79691  3.42577   1.000 78.10360  ? 163 HIS A CD2   1 ? 
ATOM   1292 C CE1   . HIS A 1 169 ? -1.22056  -7.84626  3.30533   1.000 77.22648  ? 163 HIS A CE1   1 ? 
ATOM   1293 N NE2   . HIS A 1 169 ? -1.37251  -6.72460  2.62419   1.000 80.12876  ? 163 HIS A NE2   1 ? 
ATOM   1294 N N     . HIS A 1 170 ? -4.36306  -6.53723  8.83800   1.000 67.76252  ? 164 HIS A N     1 ? 
ATOM   1295 C CA    . HIS A 1 170 ? -4.64904  -5.71777  10.00239  1.000 72.51044  ? 164 HIS A CA    1 ? 
ATOM   1296 C C     . HIS A 1 170 ? -3.43776  -4.84055  10.28713  1.000 68.32674  ? 164 HIS A C     1 ? 
ATOM   1297 O O     . HIS A 1 170 ? -2.29293  -5.23691  10.05258  1.000 70.17045  ? 164 HIS A O     1 ? 
ATOM   1298 C CB    . HIS A 1 170 ? -4.98464  -6.57195  11.22609  1.000 79.21051  ? 164 HIS A CB    1 ? 
ATOM   1299 C CG    . HIS A 1 170 ? -5.43359  -5.77243  12.41078  1.000 85.60494  ? 164 HIS A CG    1 ? 
ATOM   1300 N ND1   . HIS A 1 170 ? -4.55235  -5.24443  13.32903  1.000 83.49834  ? 164 HIS A ND1   1 ? 
ATOM   1301 C CD2   . HIS A 1 170 ? -6.67033  -5.40600  12.82333  1.000 87.36290  ? 164 HIS A CD2   1 ? 
ATOM   1302 C CE1   . HIS A 1 170 ? -5.22577  -4.58635  14.25597  1.000 84.62841  ? 164 HIS A CE1   1 ? 
ATOM   1303 N NE2   . HIS A 1 170 ? -6.51298  -4.67084  13.97355  1.000 83.32078  ? 164 HIS A NE2   1 ? 
ATOM   1304 N N     . THR A 1 171 ? -3.70039  -3.63318  10.78742  1.000 65.79304  ? 165 THR A N     1 ? 
ATOM   1305 C CA    . THR A 1 171 ? -2.63228  -2.65424  10.95016  1.000 70.30012  ? 165 THR A CA    1 ? 
ATOM   1306 C C     . THR A 1 171 ? -1.59060  -3.07991  11.97777  1.000 66.02558  ? 165 THR A C     1 ? 
ATOM   1307 O O     . THR A 1 171 ? -0.45268  -2.60232  11.91811  1.000 65.35569  ? 165 THR A O     1 ? 
ATOM   1308 C CB    . THR A 1 171 ? -3.22188  -1.29963  11.33517  1.000 65.04829  ? 165 THR A CB    1 ? 
ATOM   1309 O OG1   . THR A 1 171 ? -4.11768  -1.46317  12.44213  1.000 65.36865  ? 165 THR A OG1   1 ? 
ATOM   1310 C CG2   . THR A 1 171 ? -3.98277  -0.70623  10.15767  1.000 55.59910  ? 165 THR A CG2   1 ? 
ATOM   1311 N N     . SER A 1 172 ? -1.94597  -3.96612  12.91095  1.000 67.49009  ? 166 SER A N     1 ? 
ATOM   1312 C CA    . SER A 1 172 ? -0.97515  -4.42213  13.90047  1.000 74.82500  ? 166 SER A CA    1 ? 
ATOM   1313 C C     . SER A 1 172 ? 0.03344   -5.39118  13.29826  1.000 78.39970  ? 166 SER A C     1 ? 
ATOM   1314 O O     . SER A 1 172 ? 1.17850   -5.45691  13.75964  1.000 79.34487  ? 166 SER A O     1 ? 
ATOM   1315 C CB    . SER A 1 172 ? -1.69165  -5.07474  15.08114  1.000 74.03901  ? 166 SER A CB    1 ? 
ATOM   1316 O OG    . SER A 1 172 ? -2.30689  -6.29119  14.69643  1.000 86.58643  ? 166 SER A OG    1 ? 
ATOM   1317 N N     . ARG A 1 173 ? -0.36791  -6.15068  12.28030  1.000 80.37370  ? 167 ARG A N     1 ? 
ATOM   1318 C CA    . ARG A 1 173 ? 0.54237   -7.07691  11.62007  1.000 80.50628  ? 167 ARG A CA    1 ? 
ATOM   1319 C C     . ARG A 1 173 ? 0.82447   -6.62118  10.19501  1.000 77.15599  ? 167 ARG A C     1 ? 
ATOM   1320 O O     . ARG A 1 173 ? 0.74911   -7.42372  9.25891   1.000 81.10755  ? 167 ARG A O     1 ? 
ATOM   1321 C CB    . ARG A 1 173 ? -0.03530  -8.49359  11.60345  1.000 96.57284  ? 167 ARG A CB    1 ? 
ATOM   1322 C CG    . ARG A 1 173 ? -0.88032  -8.86360  12.81019  1.000 100.65770 ? 167 ARG A CG    1 ? 
ATOM   1323 C CD    . ARG A 1 173 ? -1.97459  -9.83900  12.39970  1.000 120.35537 ? 167 ARG A CD    1 ? 
ATOM   1324 N NE    . ARG A 1 173 ? -2.81096  -10.25720 13.51805  1.000 128.91394 ? 167 ARG A NE    1 ? 
ATOM   1325 C CZ    . ARG A 1 173 ? -4.01513  -10.79695 13.38704  1.000 122.17657 ? 167 ARG A CZ    1 ? 
ATOM   1326 N NH1   . ARG A 1 173 ? -4.56487  -10.97907 12.19758  1.000 117.65238 ? 167 ARG A NH1   1 ? 
ATOM   1327 N NH2   . ARG A 1 173 ? -4.68298  -11.16684 14.47588  1.000 121.07334 ? 167 ARG A NH2   1 ? 
ATOM   1328 N N     . TRP A 1 174 ? 1.14314   -5.34571  10.01737  1.000 74.53504  ? 168 TRP A N     1 ? 
ATOM   1329 C CA    . TRP A 1 174 ? 1.36662   -4.81410  8.67728   1.000 64.91298  ? 168 TRP A CA    1 ? 
ATOM   1330 C C     . TRP A 1 174 ? 2.61306   -5.44145  8.06798   1.000 70.80355  ? 168 TRP A C     1 ? 
ATOM   1331 O O     . TRP A 1 174 ? 3.69803   -5.33941  8.65571   1.000 84.49013  ? 168 TRP A O     1 ? 
ATOM   1332 C CB    . TRP A 1 174 ? 1.50077   -3.29688  8.71093   1.000 61.42692  ? 168 TRP A CB    1 ? 
ATOM   1333 C CG    . TRP A 1 174 ? 1.53749   -2.69681  7.34238   1.000 66.22957  ? 168 TRP A CG    1 ? 
ATOM   1334 C CD1   . TRP A 1 174 ? 2.64431   -2.31241  6.64349   1.000 69.47819  ? 168 TRP A CD1   1 ? 
ATOM   1335 C CD2   . TRP A 1 174 ? 0.41497   -2.43668  6.49199   1.000 63.63542  ? 168 TRP A CD2   1 ? 
ATOM   1336 N NE1   . TRP A 1 174 ? 2.27913   -1.81601  5.41532   1.000 75.08065  ? 168 TRP A NE1   1 ? 
ATOM   1337 C CE2   . TRP A 1 174 ? 0.91559   -1.88354  5.29743   1.000 66.32904  ? 168 TRP A CE2   1 ? 
ATOM   1338 C CE3   . TRP A 1 174 ? -0.96563  -2.61306  6.62729   1.000 61.60779  ? 168 TRP A CE3   1 ? 
ATOM   1339 C CZ2   . TRP A 1 174 ? 0.08475   -1.50270  4.24663   1.000 62.20057  ? 168 TRP A CZ2   1 ? 
ATOM   1340 C CZ3   . TRP A 1 174 ? -1.78854  -2.23637  5.58162   1.000 61.94498  ? 168 TRP A CZ3   1 ? 
ATOM   1341 C CH2   . TRP A 1 174 ? -1.26082  -1.68788  4.40689   1.000 60.75910  ? 168 TRP A CH2   1 ? 
ATOM   1342 N N     . PRO A 1 175 ? 2.51301   -6.08787  6.91244   1.000 66.74360  ? 169 PRO A N     1 ? 
ATOM   1343 C CA    . PRO A 1 175 ? 3.66728   -6.78595  6.34369   1.000 63.92904  ? 169 PRO A CA    1 ? 
ATOM   1344 C C     . PRO A 1 175 ? 4.57323   -5.84441  5.56080   1.000 69.27547  ? 169 PRO A C     1 ? 
ATOM   1345 O O     . PRO A 1 175 ? 4.26608   -4.67494  5.32685   1.000 74.98147  ? 169 PRO A O     1 ? 
ATOM   1346 C CB    . PRO A 1 175 ? 3.01909   -7.82073  5.42234   1.000 75.28568  ? 169 PRO A CB    1 ? 
ATOM   1347 C CG    . PRO A 1 175 ? 1.78167   -7.13614  4.94905   1.000 75.46097  ? 169 PRO A CG    1 ? 
ATOM   1348 C CD    . PRO A 1 175 ? 1.29419   -6.29716  6.11100   1.000 72.71657  ? 169 PRO A CD    1 ? 
ATOM   1349 N N     . LYS A 1 176 ? 5.71047   -6.39439  5.15021   1.000 84.44217  ? 170 LYS A N     1 ? 
ATOM   1350 C CA    . LYS A 1 176 ? 6.69784   -5.66363  4.37643   1.000 84.21791  ? 170 LYS A CA    1 ? 
ATOM   1351 C C     . LYS A 1 176 ? 6.30625   -5.62333  2.90167   1.000 87.83747  ? 170 LYS A C     1 ? 
ATOM   1352 O O     . LYS A 1 176 ? 5.55349   -6.46716  2.40685   1.000 88.82596  ? 170 LYS A O     1 ? 
ATOM   1353 C CB    . LYS A 1 176 ? 8.07375   -6.31405  4.52801   1.000 89.95708  ? 170 LYS A CB    1 ? 
ATOM   1354 C CG    . LYS A 1 176 ? 8.02529   -7.83697  4.46969   1.000 91.76229  ? 170 LYS A CG    1 ? 
ATOM   1355 C CD    . LYS A 1 176 ? 9.11680   -8.48990  5.30542   1.000 83.05990  ? 170 LYS A CD    1 ? 
ATOM   1356 C CE    . LYS A 1 176 ? 10.48644  -7.91854  4.98629   1.000 90.46057  ? 170 LYS A CE    1 ? 
ATOM   1357 N NZ    . LYS A 1 176 ? 11.57231  -8.67870  5.66507   1.000 93.23803  ? 170 LYS A NZ    1 ? 
ATOM   1358 N N     . ASP A 1 177 ? 6.82480   -4.61114  2.20362   1.000 87.06918  ? 171 ASP A N     1 ? 
ATOM   1359 C CA    . ASP A 1 177 ? 6.78016   -4.54705  0.74068   1.000 86.07483  ? 171 ASP A CA    1 ? 
ATOM   1360 C C     . ASP A 1 177 ? 5.34940   -4.50305  0.20500   1.000 78.92238  ? 171 ASP A C     1 ? 
ATOM   1361 O O     . ASP A 1 177 ? 5.02856   -5.13620  -0.80266  1.000 84.18657  ? 171 ASP A O     1 ? 
ATOM   1362 C CB    . ASP A 1 177 ? 7.54732   -5.71846  0.12103   1.000 90.18678  ? 171 ASP A CB    1 ? 
ATOM   1363 C CG    . ASP A 1 177 ? 9.01667   -5.71635  0.49270   1.000 98.26152  ? 171 ASP A CG    1 ? 
ATOM   1364 O OD1   . ASP A 1 177 ? 9.75816   -6.58672  -0.00993  1.000 115.96534 ? 171 ASP A OD1   1 ? 
ATOM   1365 O OD2   . ASP A 1 177 ? 9.43074   -4.84464  1.28561   1.000 111.96704 ? 171 ASP A OD2   1 ? 
ATOM   1366 N N     . VAL A 1 178 ? 4.48255   -3.74739  0.87052   1.000 75.71809  ? 172 VAL A N     1 ? 
ATOM   1367 C CA    . VAL A 1 178 ? 3.10989   -3.56669  0.41068   1.000 74.49639  ? 172 VAL A CA    1 ? 
ATOM   1368 C C     . VAL A 1 178 ? 3.08314   -2.40875  -0.57844  1.000 75.58108  ? 172 VAL A C     1 ? 
ATOM   1369 O O     . VAL A 1 178 ? 3.44729   -1.27865  -0.23554  1.000 72.69732  ? 172 VAL A O     1 ? 
ATOM   1370 C CB    . VAL A 1 178 ? 2.15173   -3.31264  1.58318   1.000 66.41835  ? 172 VAL A CB    1 ? 
ATOM   1371 C CG1   . VAL A 1 178 ? 0.85172   -2.70479  1.07384   1.000 64.60396  ? 172 VAL A CG1   1 ? 
ATOM   1372 C CG2   . VAL A 1 178 ? 1.87856   -4.60515  2.33269   1.000 65.83320  ? 172 VAL A CG2   1 ? 
ATOM   1373 N N     . THR A 1 179 ? 2.66193   -2.69095  -1.80690  1.000 76.49767  ? 173 THR A N     1 ? 
ATOM   1374 C CA    . THR A 1 179 ? 2.53215   -1.68155  -2.84632  1.000 77.38141  ? 173 THR A CA    1 ? 
ATOM   1375 C C     . THR A 1 179 ? 1.07140   -1.27182  -2.99630  1.000 74.80521  ? 173 THR A C     1 ? 
ATOM   1376 O O     . THR A 1 179 ? 0.15757   -2.07164  -2.77900  1.000 78.41031  ? 173 THR A O     1 ? 
ATOM   1377 C CB    . THR A 1 179 ? 3.07406   -2.19722  -4.18106  1.000 71.31180  ? 173 THR A CB    1 ? 
ATOM   1378 O OG1   . THR A 1 179 ? 2.85555   -3.61066  -4.27254  1.000 84.48115  ? 173 THR A OG1   1 ? 
ATOM   1379 C CG2   . THR A 1 179 ? 4.56574   -1.91372  -4.29194  1.000 77.71215  ? 173 THR A CG2   1 ? 
ATOM   1380 N N     . PHE A 1 180 ? 0.85911   -0.01291  -3.37580  1.000 71.74291  ? 174 PHE A N     1 ? 
ATOM   1381 C CA    . PHE A 1 180 ? -0.47242  0.57793   -3.37876  1.000 60.69297  ? 174 PHE A CA    1 ? 
ATOM   1382 C C     . PHE A 1 180 ? -0.96199  1.02513   -4.74701  1.000 61.14018  ? 174 PHE A C     1 ? 
ATOM   1383 O O     . PHE A 1 180 ? -2.17587  1.09603   -4.95138  1.000 66.96250  ? 174 PHE A O     1 ? 
ATOM   1384 C CB    . PHE A 1 180 ? -0.51763  1.78769   -2.43160  1.000 60.25893  ? 174 PHE A CB    1 ? 
ATOM   1385 C CG    . PHE A 1 180 ? -0.58305  1.41870   -0.97841  1.000 69.35084  ? 174 PHE A CG    1 ? 
ATOM   1386 C CD1   . PHE A 1 180 ? -1.66185  0.70946   -0.47750  1.000 68.81192  ? 174 PHE A CD1   1 ? 
ATOM   1387 C CD2   . PHE A 1 180 ? 0.43533   1.78116   -0.11269  1.000 60.41347  ? 174 PHE A CD2   1 ? 
ATOM   1388 C CE1   . PHE A 1 180 ? -1.72429  0.36906   0.86040   1.000 62.38023  ? 174 PHE A CE1   1 ? 
ATOM   1389 C CE2   . PHE A 1 180 ? 0.37886   1.44379   1.22538   1.000 52.88131  ? 174 PHE A CE2   1 ? 
ATOM   1390 C CZ    . PHE A 1 180 ? -0.70227  0.73614   1.71244   1.000 53.62554  ? 174 PHE A CZ    1 ? 
ATOM   1391 N N     . SER A 1 181 ? -0.06490  1.32802   -5.68163  1.000 57.63040  ? 175 SER A N     1 ? 
ATOM   1392 C CA    . SER A 1 181 ? -0.47171  1.93566   -6.94196  1.000 65.50983  ? 175 SER A CA    1 ? 
ATOM   1393 C C     . SER A 1 181 ? -1.32105  0.97945   -7.77165  1.000 63.73210  ? 175 SER A C     1 ? 
ATOM   1394 O O     . SER A 1 181 ? -1.06061  -0.22559  -7.82713  1.000 62.10051  ? 175 SER A O     1 ? 
ATOM   1395 C CB    . SER A 1 181 ? 0.75675   2.37119   -7.74036  1.000 64.47770  ? 175 SER A CB    1 ? 
ATOM   1396 O OG    . SER A 1 181 ? 1.66700   1.29818   -7.90300  1.000 78.51715  ? 175 SER A OG    1 ? 
ATOM   1397 N N     . GLY A 1 182 ? -2.34889  1.53029   -8.41595  1.000 63.87172  ? 176 GLY A N     1 ? 
ATOM   1398 C CA    . GLY A 1 182 ? -3.19626  0.76552   -9.30840  1.000 55.06784  ? 176 GLY A CA    1 ? 
ATOM   1399 C C     . GLY A 1 182 ? -4.15843  -0.18856  -8.64117  1.000 67.85828  ? 176 GLY A C     1 ? 
ATOM   1400 O O     . GLY A 1 182 ? -4.82783  -0.95550  -9.34019  1.000 68.50125  ? 176 GLY A O     1 ? 
ATOM   1401 N N     . LYS A 1 183 ? -4.26109  -0.16446  -7.31601  1.000 52.90625  ? 177 LYS A N     1 ? 
ATOM   1402 C CA    . LYS A 1 183 ? -5.09404  -1.10146  -6.57738  1.000 62.61252  ? 177 LYS A CA    1 ? 
ATOM   1403 C C     . LYS A 1 183 ? -6.31929  -0.39734  -6.01150  1.000 62.60169  ? 177 LYS A C     1 ? 
ATOM   1404 O O     . LYS A 1 183 ? -6.24812  0.76781   -5.60772  1.000 65.08381  ? 177 LYS A O     1 ? 
ATOM   1405 C CB    . LYS A 1 183 ? -4.30904  -1.75219  -5.43501  1.000 58.38172  ? 177 LYS A CB    1 ? 
ATOM   1406 C CG    . LYS A 1 183 ? -3.18832  -2.67182  -5.88316  1.000 59.26857  ? 177 LYS A CG    1 ? 
ATOM   1407 C CD    . LYS A 1 183 ? -2.35244  -3.12425  -4.69619  1.000 51.08400  ? 177 LYS A CD    1 ? 
ATOM   1408 C CE    . LYS A 1 183 ? -1.36836  -4.21210  -5.09128  1.000 67.93112  ? 177 LYS A CE    1 ? 
ATOM   1409 N NZ    . LYS A 1 183 ? -0.10576  -4.12489  -4.30599  1.000 66.25442  ? 177 LYS A NZ    1 ? 
ATOM   1410 N N     . ARG A 1 184 ? -7.44207  -1.11250  -5.98794  1.000 63.85195  ? 178 ARG A N     1 ? 
ATOM   1411 C CA    . ARG A 1 184 ? -8.63281  -0.67630  -5.26729  1.000 56.39849  ? 178 ARG A CA    1 ? 
ATOM   1412 C C     . ARG A 1 184 ? -8.49696  -1.14736  -3.82438  1.000 58.72795  ? 178 ARG A C     1 ? 
ATOM   1413 O O     . ARG A 1 184 ? -8.49424  -2.35324  -3.55563  1.000 60.00491  ? 178 ARG A O     1 ? 
ATOM   1414 C CB    . ARG A 1 184 ? -9.89855  -1.23257  -5.91347  1.000 59.85449  ? 178 ARG A CB    1 ? 
ATOM   1415 C CG    . ARG A 1 184 ? -10.11871 -0.79369  -7.34993  1.000 59.00915  ? 178 ARG A CG    1 ? 
ATOM   1416 C CD    . ARG A 1 184 ? -11.50686 -1.18822  -7.83108  1.000 60.62269  ? 178 ARG A CD    1 ? 
ATOM   1417 N NE    . ARG A 1 184 ? -12.26282 -0.04524  -8.32910  1.000 72.13926  ? 178 ARG A NE    1 ? 
ATOM   1418 C CZ    . ARG A 1 184 ? -12.19901 0.41048   -9.57254  1.000 66.99986  ? 178 ARG A CZ    1 ? 
ATOM   1419 N NH1   . ARG A 1 184 ? -11.42121 -0.15959  -10.47831 1.000 68.70166  ? 178 ARG A NH1   1 ? 
ATOM   1420 N NH2   . ARG A 1 184 ? -12.93568 1.46315   -9.91646  1.000 74.37926  ? 178 ARG A NH2   1 ? 
ATOM   1421 N N     . VAL A 1 185 ? -8.37790  -0.20089  -2.89789  1.000 55.20185  ? 179 VAL A N     1 ? 
ATOM   1422 C CA    . VAL A 1 185 ? -8.08559  -0.49645  -1.50160  1.000 54.95985  ? 179 VAL A CA    1 ? 
ATOM   1423 C C     . VAL A 1 185 ? -9.26064  -0.05086  -0.64101  1.000 53.57174  ? 179 VAL A C     1 ? 
ATOM   1424 O O     . VAL A 1 185 ? -9.85791  1.00126   -0.88461  1.000 59.89547  ? 179 VAL A O     1 ? 
ATOM   1425 C CB    . VAL A 1 185 ? -6.77867  0.18704   -1.04733  1.000 54.18052  ? 179 VAL A CB    1 ? 
ATOM   1426 C CG1   . VAL A 1 185 ? -6.44157  -0.19096  0.38476   1.000 51.67511  ? 179 VAL A CG1   1 ? 
ATOM   1427 C CG2   . VAL A 1 185 ? -5.63988  -0.19371  -1.97964  1.000 51.14501  ? 179 VAL A CG2   1 ? 
ATOM   1428 N N     . GLY A 1 186 ? -9.58754  -0.86090  0.35582   1.000 53.33089  ? 180 GLY A N     1 ? 
ATOM   1429 C CA    . GLY A 1 186 ? -10.62936 -0.52890  1.31840   1.000 56.29601  ? 180 GLY A CA    1 ? 
ATOM   1430 C C     . GLY A 1 186 ? -10.07211 -0.53492  2.72505   1.000 56.50743  ? 180 GLY A C     1 ? 
ATOM   1431 O O     . GLY A 1 186 ? -9.23509  -1.37372  3.06664   1.000 66.49873  ? 180 GLY A O     1 ? 
ATOM   1432 N N     . VAL A 1 187 ? -10.53509 0.41023   3.54085   1.000 53.75263  ? 181 VAL A N     1 ? 
ATOM   1433 C CA    . VAL A 1 187 ? -10.09593 0.55736   4.92286   1.000 62.04608  ? 181 VAL A CA    1 ? 
ATOM   1434 C C     . VAL A 1 187 ? -11.32156 0.51438   5.82320   1.000 62.22552  ? 181 VAL A C     1 ? 
ATOM   1435 O O     . VAL A 1 187 ? -12.30695 1.21836   5.57305   1.000 58.14910  ? 181 VAL A O     1 ? 
ATOM   1436 C CB    . VAL A 1 187 ? -9.30801  1.86371   5.13673   1.000 59.25963  ? 181 VAL A CB    1 ? 
ATOM   1437 C CG1   . VAL A 1 187 ? -8.87297  1.99076   6.58845   1.000 54.99607  ? 181 VAL A CG1   1 ? 
ATOM   1438 C CG2   . VAL A 1 187 ? -8.10193  1.91632   4.21188   1.000 54.00066  ? 181 VAL A CG2   1 ? 
ATOM   1439 N N     . ILE A 1 188 ? -11.25983 -0.31102  6.86403   1.000 63.28989  ? 182 ILE A N     1 ? 
ATOM   1440 C CA    . ILE A 1 188 ? -12.32003 -0.41701  7.85930   1.000 65.54908  ? 182 ILE A CA    1 ? 
ATOM   1441 C C     . ILE A 1 188 ? -11.77581 0.12834   9.17208   1.000 75.11262  ? 182 ILE A C     1 ? 
ATOM   1442 O O     . ILE A 1 188 ? -10.77093 -0.37256  9.69280   1.000 76.19429  ? 182 ILE A O     1 ? 
ATOM   1443 C CB    . ILE A 1 188 ? -12.81009 -1.86415  8.01934   1.000 67.06239  ? 182 ILE A CB    1 ? 
ATOM   1444 C CG1   . ILE A 1 188 ? -13.73133 -2.24678  6.86076   1.000 83.14780  ? 182 ILE A CG1   1 ? 
ATOM   1445 C CG2   . ILE A 1 188 ? -13.54827 -2.03230  9.33716   1.000 69.12702  ? 182 ILE A CG2   1 ? 
ATOM   1446 C CD1   . ILE A 1 188 ? -13.82135 -3.73777  6.61865   1.000 71.74241  ? 182 ILE A CD1   1 ? 
ATOM   1447 N N     . GLY A 1 189 ? -12.43100 1.15782   9.70139   1.000 75.47207  ? 183 GLY A N     1 ? 
ATOM   1448 C CA    . GLY A 1 189 ? -11.99426 1.77022   10.93968  1.000 73.83834  ? 183 GLY A CA    1 ? 
ATOM   1449 C C     . GLY A 1 189 ? -11.50959 3.19334   10.76223  1.000 72.29147  ? 183 GLY A C     1 ? 
ATOM   1450 O O     . GLY A 1 189 ? -10.62294 3.45603   9.94426   1.000 72.07301  ? 183 GLY A O     1 ? 
ATOM   1451 N N     . THR A 1 190 ? -12.08310 4.12321   11.52526  1.000 75.19225  ? 184 THR A N     1 ? 
ATOM   1452 C CA    . THR A 1 190 ? -11.70069 5.52605   11.42404  1.000 73.04941  ? 184 THR A CA    1 ? 
ATOM   1453 C C     . THR A 1 190 ? -11.21566 6.06401   12.76471  1.000 83.65876  ? 184 THR A C     1 ? 
ATOM   1454 O O     . THR A 1 190 ? -11.64812 7.13344   13.20699  1.000 78.73566  ? 184 THR A O     1 ? 
ATOM   1455 C CB    . THR A 1 190 ? -12.86918 6.36783   10.90624  1.000 76.68964  ? 184 THR A CB    1 ? 
ATOM   1456 O OG1   . THR A 1 190 ? -14.06154 6.03221   11.62643  1.000 75.90017  ? 184 THR A OG1   1 ? 
ATOM   1457 C CG2   . THR A 1 190 ? -13.08743 6.11585   9.42323   1.000 65.69365  ? 184 THR A CG2   1 ? 
ATOM   1458 N N     . GLY A 1 191 ? -10.32503 5.32624   13.41824  1.000 93.30632  ? 185 GLY A N     1 ? 
ATOM   1459 C CA    . GLY A 1 191 ? -9.65329  5.79142   14.61251  1.000 81.46589  ? 185 GLY A CA    1 ? 
ATOM   1460 C C     . GLY A 1 191 ? -8.33756  6.45764   14.27387  1.000 78.09487  ? 185 GLY A C     1 ? 
ATOM   1461 O O     . GLY A 1 191 ? -8.06834  6.81230   13.12372  1.000 74.04369  ? 185 GLY A O     1 ? 
ATOM   1462 N N     . SER A 1 192 ? -7.49999  6.62594   15.30060  1.000 72.60797  ? 186 SER A N     1 ? 
ATOM   1463 C CA    . SER A 1 192 ? -6.18743  7.22791   15.08372  1.000 70.89147  ? 186 SER A CA    1 ? 
ATOM   1464 C C     . SER A 1 192 ? -5.35560  6.39766   14.11437  1.000 69.52980  ? 186 SER A C     1 ? 
ATOM   1465 O O     . SER A 1 192 ? -4.60495  6.94637   13.29904  1.000 79.53619  ? 186 SER A O     1 ? 
ATOM   1466 C CB    . SER A 1 192 ? -5.45519  7.39156   16.41484  1.000 82.81140  ? 186 SER A CB    1 ? 
ATOM   1467 O OG    . SER A 1 192 ? -5.71953  6.29947   17.27621  1.000 91.04137  ? 186 SER A OG    1 ? 
ATOM   1468 N N     . THR A 1 193 ? -5.47923  5.07149   14.18478  1.000 72.07384  ? 187 THR A N     1 ? 
ATOM   1469 C CA    . THR A 1 193 ? -4.77326  4.21237   13.24098  1.000 70.47758  ? 187 THR A CA    1 ? 
ATOM   1470 C C     . THR A 1 193 ? -5.39324  4.30407   11.85237  1.000 62.44358  ? 187 THR A C     1 ? 
ATOM   1471 O O     . THR A 1 193 ? -4.68219  4.45392   10.85160  1.000 56.75847  ? 187 THR A O     1 ? 
ATOM   1472 C CB    . THR A 1 193 ? -4.78092  2.76704   13.73853  1.000 67.64123  ? 187 THR A CB    1 ? 
ATOM   1473 O OG1   . THR A 1 193 ? -3.95701  2.65621   14.90602  1.000 71.05291  ? 187 THR A OG1   1 ? 
ATOM   1474 C CG2   . THR A 1 193 ? -4.25607  1.83960   12.66799  1.000 59.79268  ? 187 THR A CG2   1 ? 
ATOM   1475 N N     . GLY A 1 194 ? -6.72280  4.21864   11.77417  1.000 65.98313  ? 188 GLY A N     1 ? 
ATOM   1476 C CA    . GLY A 1 194 ? -7.38468  4.31579   10.48356  1.000 62.33631  ? 188 GLY A CA    1 ? 
ATOM   1477 C C     . GLY A 1 194 ? -7.17485  5.66102   9.81902   1.000 61.37888  ? 188 GLY A C     1 ? 
ATOM   1478 O O     . GLY A 1 194 ? -6.98933  5.74109   8.60188   1.000 56.67046  ? 188 GLY A O     1 ? 
ATOM   1479 N N     . VAL A 1 195 ? -7.19582  6.73736   10.60779  1.000 57.68225  ? 189 VAL A N     1 ? 
ATOM   1480 C CA    . VAL A 1 195 ? -6.96806  8.06928   10.05499  1.000 57.85071  ? 189 VAL A CA    1 ? 
ATOM   1481 C C     . VAL A 1 195 ? -5.56894  8.16247   9.45759   1.000 61.81439  ? 189 VAL A C     1 ? 
ATOM   1482 O O     . VAL A 1 195 ? -5.38328  8.65965   8.34158   1.000 61.37170  ? 189 VAL A O     1 ? 
ATOM   1483 C CB    . VAL A 1 195 ? -7.19917  9.14496   11.13191  1.000 64.86424  ? 189 VAL A CB    1 ? 
ATOM   1484 C CG1   . VAL A 1 195 ? -6.46858  10.42437  10.77312  1.000 65.14146  ? 189 VAL A CG1   1 ? 
ATOM   1485 C CG2   . VAL A 1 195 ? -8.68775  9.41275   11.30152  1.000 61.35443  ? 189 VAL A CG2   1 ? 
ATOM   1486 N N     . GLN A 1 196 ? -4.56579  7.66296   10.18331  1.000 58.13012  ? 190 GLN A N     1 ? 
ATOM   1487 C CA    . GLN A 1 196 ? -3.18728  7.77825   9.71596   1.000 55.30992  ? 190 GLN A CA    1 ? 
ATOM   1488 C C     . GLN A 1 196 ? -2.95520  6.96701   8.44627   1.000 56.17966  ? 190 GLN A C     1 ? 
ATOM   1489 O O     . GLN A 1 196 ? -2.20570  7.39446   7.56053   1.000 67.52528  ? 190 GLN A O     1 ? 
ATOM   1490 C CB    . GLN A 1 196 ? -2.22405  7.34203   10.81896  1.000 59.36098  ? 190 GLN A CB    1 ? 
ATOM   1491 C CG    . GLN A 1 196 ? -1.99941  8.39779   11.88912  1.000 62.88353  ? 190 GLN A CG    1 ? 
ATOM   1492 C CD    . GLN A 1 196 ? -1.36784  7.83241   13.14553  1.000 69.93767  ? 190 GLN A CD    1 ? 
ATOM   1493 O OE1   . GLN A 1 196 ? -1.00284  6.65765   13.19751  1.000 63.12413  ? 190 GLN A OE1   1 ? 
ATOM   1494 N NE2   . GLN A 1 196 ? -1.23664  8.66900   14.16846  1.000 71.99626  ? 190 GLN A NE2   1 ? 
ATOM   1495 N N     . VAL A 1 197 ? -3.58721  5.79647   8.33719   1.000 58.03350  ? 191 VAL A N     1 ? 
ATOM   1496 C CA    . VAL A 1 197 ? -3.42596  4.97888   7.13826   1.000 54.24824  ? 191 VAL A CA    1 ? 
ATOM   1497 C C     . VAL A 1 197 ? -4.12691  5.62596   5.94998   1.000 65.62315  ? 191 VAL A C     1 ? 
ATOM   1498 O O     . VAL A 1 197 ? -3.60154  5.63336   4.82992   1.000 65.37877  ? 191 VAL A O     1 ? 
ATOM   1499 C CB    . VAL A 1 197 ? -3.94504  3.55087   7.39048   1.000 55.06505  ? 191 VAL A CB    1 ? 
ATOM   1500 C CG1   . VAL A 1 197 ? -3.91057  2.73391   6.10682   1.000 55.99675  ? 191 VAL A CG1   1 ? 
ATOM   1501 C CG2   . VAL A 1 197 ? -3.12826  2.87287   8.47248   1.000 43.49518  ? 191 VAL A CG2   1 ? 
ATOM   1502 N N     . ILE A 1 198 ? -5.31466  6.19027   6.17586   1.000 57.52024  ? 192 ILE A N     1 ? 
ATOM   1503 C CA    . ILE A 1 198 ? -6.11990  6.70962   5.07380   1.000 55.10911  ? 192 ILE A CA    1 ? 
ATOM   1504 C C     . ILE A 1 198 ? -5.44122  7.91436   4.42989   1.000 60.63694  ? 192 ILE A C     1 ? 
ATOM   1505 O O     . ILE A 1 198 ? -5.34040  8.00383   3.20043   1.000 46.88152  ? 192 ILE A O     1 ? 
ATOM   1506 C CB    . ILE A 1 198 ? -7.53976  7.04506   5.56492   1.000 62.07797  ? 192 ILE A CB    1 ? 
ATOM   1507 C CG1   . ILE A 1 198 ? -8.36783  5.76327   5.68921   1.000 49.86681  ? 192 ILE A CG1   1 ? 
ATOM   1508 C CG2   . ILE A 1 198 ? -8.21704  8.03673   4.62959   1.000 56.14201  ? 192 ILE A CG2   1 ? 
ATOM   1509 C CD1   . ILE A 1 198 ? -9.54938  5.88400   6.62304   1.000 49.64742  ? 192 ILE A CD1   1 ? 
ATOM   1510 N N     . THR A 1 199 ? -4.96032  8.85665   5.24674   1.000 60.69578  ? 193 THR A N     1 ? 
ATOM   1511 C CA    . THR A 1 199 ? -4.26001  10.01338  4.69488   1.000 49.49802  ? 193 THR A CA    1 ? 
ATOM   1512 C C     . THR A 1 199 ? -2.96754  9.60992   4.00026   1.000 63.71472  ? 193 THR A C     1 ? 
ATOM   1513 O O     . THR A 1 199 ? -2.52301  10.29265  3.07017   1.000 70.97566  ? 193 THR A O     1 ? 
ATOM   1514 C CB    . THR A 1 199 ? -3.95476  11.03313  5.79243   1.000 58.55242  ? 193 THR A CB    1 ? 
ATOM   1515 O OG1   . THR A 1 199 ? -2.84180  10.57964  6.57379   1.000 92.28253  ? 193 THR A OG1   1 ? 
ATOM   1516 C CG2   . THR A 1 199 ? -5.15095  11.22161  6.69061   1.000 55.64262  ? 193 THR A CG2   1 ? 
ATOM   1517 N N     . ALA A 1 200 ? -2.35383  8.50778   4.43128   1.000 49.53776  ? 194 ALA A N     1 ? 
ATOM   1518 C CA    . ALA A 1 200 ? -1.06595  8.10959   3.87909   1.000 54.00646  ? 194 ALA A CA    1 ? 
ATOM   1519 C C     . ALA A 1 200 ? -1.19655  7.42729   2.52340   1.000 56.32052  ? 194 ALA A C     1 ? 
ATOM   1520 O O     . ALA A 1 200 ? -0.29526  7.55179   1.68681   1.000 65.10592  ? 194 ALA A O     1 ? 
ATOM   1521 C CB    . ALA A 1 200 ? -0.34001  7.18542   4.85823   1.000 58.11809  ? 194 ALA A CB    1 ? 
ATOM   1522 N N     . ILE A 1 201 ? -2.29586  6.71715   2.27984   1.000 57.92878  ? 195 ILE A N     1 ? 
ATOM   1523 C CA    . ILE A 1 201 ? -2.40944  5.87117   1.10005   1.000 63.25092  ? 195 ILE A CA    1 ? 
ATOM   1524 C C     . ILE A 1 201 ? -3.38741  6.40474   0.05872   1.000 57.75118  ? 195 ILE A C     1 ? 
ATOM   1525 O O     . ILE A 1 201 ? -3.32997  5.95846   -1.09709  1.000 57.74865  ? 195 ILE A O     1 ? 
ATOM   1526 C CB    . ILE A 1 201 ? -2.79085  4.42767   1.48781   1.000 58.42851  ? 195 ILE A CB    1 ? 
ATOM   1527 C CG1   . ILE A 1 201 ? -4.27136  4.35249   1.86536   1.000 57.82571  ? 195 ILE A CG1   1 ? 
ATOM   1528 C CG2   . ILE A 1 201 ? -1.91929  3.93908   2.63307   1.000 65.77140  ? 195 ILE A CG2   1 ? 
ATOM   1529 C CD1   . ILE A 1 201 ? -4.78553  2.94396   2.04203   1.000 62.15845  ? 195 ILE A CD1   1 ? 
ATOM   1530 N N     . ALA A 1 202 ? -4.27633  7.33665   0.41846   1.000 57.39170  ? 196 ALA A N     1 ? 
ATOM   1531 C CA    . ALA A 1 202 ? -5.29896  7.78188   -0.52563  1.000 61.39551  ? 196 ALA A CA    1 ? 
ATOM   1532 C C     . ALA A 1 202 ? -4.68865  8.40140   -1.77540  1.000 64.79848  ? 196 ALA A C     1 ? 
ATOM   1533 O O     . ALA A 1 202 ? -5.25229  8.27565   -2.86871  1.000 64.38843  ? 196 ALA A O     1 ? 
ATOM   1534 C CB    . ALA A 1 202 ? -6.24416  8.77417   0.14801   1.000 48.92401  ? 196 ALA A CB    1 ? 
ATOM   1535 N N     . SER A 1 203 ? -3.54197  9.06866   -1.63895  1.000 67.20599  ? 197 SER A N     1 ? 
ATOM   1536 C CA    . SER A 1 203 ? -2.85864  9.61488   -2.80396  1.000 63.70624  ? 197 SER A CA    1 ? 
ATOM   1537 C C     . SER A 1 203 ? -2.15229  8.53751   -3.61563  1.000 70.53060  ? 197 SER A C     1 ? 
ATOM   1538 O O     . SER A 1 203 ? -1.76393  8.79546   -4.75976  1.000 71.21686  ? 197 SER A O     1 ? 
ATOM   1539 C CB    . SER A 1 203 ? -1.85076  10.67879  -2.36800  1.000 67.93200  ? 197 SER A CB    1 ? 
ATOM   1540 O OG    . SER A 1 203 ? -1.12737  10.25218  -1.22589  1.000 67.65673  ? 197 SER A OG    1 ? 
ATOM   1541 N N     . GLN A 1 204 ? -1.98662  7.33856   -3.05580  1.000 60.61093  ? 198 GLN A N     1 ? 
ATOM   1542 C CA    . GLN A 1 204 ? -1.21961  6.28072   -3.69859  1.000 58.66305  ? 198 GLN A CA    1 ? 
ATOM   1543 C C     . GLN A 1 204 ? -2.08045  5.22942   -4.38509  1.000 59.33214  ? 198 GLN A C     1 ? 
ATOM   1544 O O     . GLN A 1 204 ? -1.57376  4.51324   -5.25520  1.000 60.96516  ? 198 GLN A O     1 ? 
ATOM   1545 C CB    . GLN A 1 204 ? -0.32086  5.58317   -2.66949  1.000 69.87058  ? 198 GLN A CB    1 ? 
ATOM   1546 C CG    . GLN A 1 204 ? 0.62363   6.51400   -1.92863  1.000 73.59514  ? 198 GLN A CG    1 ? 
ATOM   1547 C CD    . GLN A 1 204 ? 2.07261   6.09010   -2.05256  1.000 89.17013  ? 198 GLN A CD    1 ? 
ATOM   1548 O OE1   . GLN A 1 204 ? 2.56321   5.28005   -1.26603  1.000 82.91581  ? 198 GLN A OE1   1 ? 
ATOM   1549 N NE2   . GLN A 1 204 ? 2.76717   6.63746   -3.04309  1.000 100.67779 ? 198 GLN A NE2   1 ? 
ATOM   1550 N N     . VAL A 1 205 ? -3.35376  5.11726   -4.02371  1.000 55.99610  ? 199 VAL A N     1 ? 
ATOM   1551 C CA    . VAL A 1 205 ? -4.20281  4.04105   -4.50551  1.000 60.83293  ? 199 VAL A CA    1 ? 
ATOM   1552 C C     . VAL A 1 205 ? -5.01438  4.52153   -5.70118  1.000 54.88510  ? 199 VAL A C     1 ? 
ATOM   1553 O O     . VAL A 1 205 ? -5.18749  5.72096   -5.93540  1.000 57.87255  ? 199 VAL A O     1 ? 
ATOM   1554 C CB    . VAL A 1 205 ? -5.12861  3.50751   -3.38873  1.000 57.82561  ? 199 VAL A CB    1 ? 
ATOM   1555 C CG1   . VAL A 1 205 ? -4.31296  3.12788   -2.16473  1.000 60.51931  ? 199 VAL A CG1   1 ? 
ATOM   1556 C CG2   . VAL A 1 205 ? -6.18198  4.54423   -3.03203  1.000 52.94728  ? 199 VAL A CG2   1 ? 
ATOM   1557 N N     . LYS A 1 206 ? -5.51970  3.55967   -6.47824  1.000 57.40561  ? 200 LYS A N     1 ? 
ATOM   1558 C CA    . LYS A 1 206 ? -6.40676  3.89599   -7.58703  1.000 61.76219  ? 200 LYS A CA    1 ? 
ATOM   1559 C C     . LYS A 1 206 ? -7.76973  4.34787   -7.07942  1.000 65.34733  ? 200 LYS A C     1 ? 
ATOM   1560 O O     . LYS A 1 206 ? -8.33001  5.33028   -7.57847  1.000 67.46743  ? 200 LYS A O     1 ? 
ATOM   1561 C CB    . LYS A 1 206 ? -6.55356  2.70066   -8.52825  1.000 56.33817  ? 200 LYS A CB    1 ? 
ATOM   1562 C CG    . LYS A 1 206 ? -7.57437  2.90947   -9.63728  1.000 61.71096  ? 200 LYS A CG    1 ? 
ATOM   1563 C CD    . LYS A 1 206 ? -7.35564  1.93859   -10.78518 1.000 68.35409  ? 200 LYS A CD    1 ? 
ATOM   1564 C CE    . LYS A 1 206 ? -7.92602  0.56741   -10.46374 1.000 72.31063  ? 200 LYS A CE    1 ? 
ATOM   1565 N NZ    . LYS A 1 206 ? -8.02297  -0.29316  -11.67528 1.000 90.19223  ? 200 LYS A NZ    1 ? 
ATOM   1566 N N     . HIS A 1 207 ? -8.31959  3.64239   -6.09344  1.000 55.25780  ? 201 HIS A N     1 ? 
ATOM   1567 C CA    . HIS A 1 207 ? -9.55093  4.05956   -5.44028  1.000 57.19779  ? 201 HIS A CA    1 ? 
ATOM   1568 C C     . HIS A 1 207 ? -9.52297  3.59693   -3.99238  1.000 63.94650  ? 201 HIS A C     1 ? 
ATOM   1569 O O     . HIS A 1 207 ? -9.12189  2.46675   -3.70143  1.000 62.34125  ? 201 HIS A O     1 ? 
ATOM   1570 C CB    . HIS A 1 207 ? -10.79323 3.50450   -6.14519  1.000 54.72170  ? 201 HIS A CB    1 ? 
ATOM   1571 C CG    . HIS A 1 207 ? -12.05438 4.23333   -5.79957  1.000 56.44614  ? 201 HIS A CG    1 ? 
ATOM   1572 N ND1   . HIS A 1 207 ? -12.51572 5.31047   -6.52590  1.000 62.33452  ? 201 HIS A ND1   1 ? 
ATOM   1573 C CD2   . HIS A 1 207 ? -12.94529 4.04724   -4.79698  1.000 49.45352  ? 201 HIS A CD2   1 ? 
ATOM   1574 C CE1   . HIS A 1 207 ? -13.63918 5.75194   -5.98965  1.000 60.40998  ? 201 HIS A CE1   1 ? 
ATOM   1575 N NE2   . HIS A 1 207 ? -13.92191 5.00277   -4.93893  1.000 59.01376  ? 201 HIS A NE2   1 ? 
ATOM   1576 N N     . LEU A 1 208 ? -9.94889  4.47828   -3.09298  1.000 62.78810  ? 202 LEU A N     1 ? 
ATOM   1577 C CA    . LEU A 1 208 ? -10.01084 4.18985   -1.66863  1.000 55.36454  ? 202 LEU A CA    1 ? 
ATOM   1578 C C     . LEU A 1 208 ? -11.45977 4.20147   -1.20208  1.000 58.79785  ? 202 LEU A C     1 ? 
ATOM   1579 O O     . LEU A 1 208 ? -12.23903 5.07996   -1.58517  1.000 63.79386  ? 202 LEU A O     1 ? 
ATOM   1580 C CB    . LEU A 1 208 ? -9.19759  5.20743   -0.86423  1.000 51.48231  ? 202 LEU A CB    1 ? 
ATOM   1581 C CG    . LEU A 1 208 ? -9.16126  4.97828   0.64793   1.000 52.52005  ? 202 LEU A CG    1 ? 
ATOM   1582 C CD1   . LEU A 1 208 ? -8.41638  3.69368   0.97584   1.000 41.62343  ? 202 LEU A CD1   1 ? 
ATOM   1583 C CD2   . LEU A 1 208 ? -8.53813  6.16641   1.36279   1.000 57.31849  ? 202 LEU A CD2   1 ? 
ATOM   1584 N N     . THR A 1 209 ? -11.81631 3.22090   -0.37675  1.000 53.13032  ? 203 THR A N     1 ? 
ATOM   1585 C CA    . THR A 1 209 ? -13.14889 3.12195   0.20486   1.000 60.52185  ? 203 THR A CA    1 ? 
ATOM   1586 C C     . THR A 1 209 ? -13.01273 3.06986   1.71890   1.000 60.75159  ? 203 THR A C     1 ? 
ATOM   1587 O O     . THR A 1 209 ? -12.34364 2.17981   2.25528   1.000 61.90955  ? 203 THR A O     1 ? 
ATOM   1588 C CB    . THR A 1 209 ? -13.89221 1.88878   -0.31226  1.000 62.67451  ? 203 THR A CB    1 ? 
ATOM   1589 O OG1   . THR A 1 209 ? -13.93467 1.91930   -1.74475  1.000 60.56398  ? 203 THR A OG1   1 ? 
ATOM   1590 C CG2   . THR A 1 209 ? -15.31328 1.86450   0.22977   1.000 60.63577  ? 203 THR A CG2   1 ? 
ATOM   1591 N N     . VAL A 1 210 ? -13.64251 4.02075   2.40078   1.000 57.00482  ? 204 VAL A N     1 ? 
ATOM   1592 C CA    . VAL A 1 210 ? -13.58296 4.12606   3.85330   1.000 62.85909  ? 204 VAL A CA    1 ? 
ATOM   1593 C C     . VAL A 1 210 ? -14.89918 3.62087   4.42624   1.000 62.95238  ? 204 VAL A C     1 ? 
ATOM   1594 O O     . VAL A 1 210 ? -15.96229 4.19755   4.16572   1.000 60.57138  ? 204 VAL A O     1 ? 
ATOM   1595 C CB    . VAL A 1 210 ? -13.30456 5.56958   4.29948   1.000 58.40267  ? 204 VAL A CB    1 ? 
ATOM   1596 C CG1   . VAL A 1 210 ? -13.07012 5.62228   5.79806   1.000 49.74617  ? 204 VAL A CG1   1 ? 
ATOM   1597 C CG2   . VAL A 1 210 ? -12.10832 6.13337   3.54807   1.000 49.69858  ? 204 VAL A CG2   1 ? 
ATOM   1598 N N     . PHE A 1 211 ? -14.83015 2.54522   5.20638   1.000 55.36800  ? 205 PHE A N     1 ? 
ATOM   1599 C CA    . PHE A 1 211 ? -15.99606 1.97944   5.88122   1.000 66.12233  ? 205 PHE A CA    1 ? 
ATOM   1600 C C     . PHE A 1 211 ? -16.02050 2.53841   7.29982   1.000 65.56091  ? 205 PHE A C     1 ? 
ATOM   1601 O O     . PHE A 1 211 ? -15.35243 2.01868   8.19734   1.000 66.93413  ? 205 PHE A O     1 ? 
ATOM   1602 C CB    . PHE A 1 211 ? -15.94302 0.45580   5.86894   1.000 66.01282  ? 205 PHE A CB    1 ? 
ATOM   1603 C CG    . PHE A 1 211 ? -15.90650 -0.13653  4.48831   1.000 63.11467  ? 205 PHE A CG    1 ? 
ATOM   1604 C CD1   . PHE A 1 211 ? -17.06895 -0.27532  3.74805   1.000 67.31631  ? 205 PHE A CD1   1 ? 
ATOM   1605 C CD2   . PHE A 1 211 ? -14.70854 -0.54746  3.92776   1.000 61.27367  ? 205 PHE A CD2   1 ? 
ATOM   1606 C CE1   . PHE A 1 211 ? -17.03792 -0.81856  2.47670   1.000 62.84678  ? 205 PHE A CE1   1 ? 
ATOM   1607 C CE2   . PHE A 1 211 ? -14.67088 -1.09103  2.65735   1.000 65.91298  ? 205 PHE A CE2   1 ? 
ATOM   1608 C CZ    . PHE A 1 211 ? -15.83724 -1.22686  1.93113   1.000 58.54819  ? 205 PHE A CZ    1 ? 
ATOM   1609 N N     . GLN A 1 212 ? -16.79604 3.60201   7.49757   1.000 63.31596  ? 206 GLN A N     1 ? 
ATOM   1610 C CA    . GLN A 1 212 ? -16.81688 4.34803   8.75118   1.000 62.15124  ? 206 GLN A CA    1 ? 
ATOM   1611 C C     . GLN A 1 212 ? -18.01153 3.89935   9.58607   1.000 68.37941  ? 206 GLN A C     1 ? 
ATOM   1612 O O     . GLN A 1 212 ? -19.16422 4.15132   9.21922   1.000 74.51678  ? 206 GLN A O     1 ? 
ATOM   1613 C CB    . GLN A 1 212 ? -16.87149 5.84913   8.47571   1.000 64.87667  ? 206 GLN A CB    1 ? 
ATOM   1614 C CG    . GLN A 1 212 ? -17.10309 6.70690   9.70620   1.000 58.54037  ? 206 GLN A CG    1 ? 
ATOM   1615 C CD    . GLN A 1 212 ? -17.46193 8.13543   9.35213   1.000 66.39823  ? 206 GLN A CD    1 ? 
ATOM   1616 O OE1   . GLN A 1 212 ? -16.59004 8.99748   9.24277   1.000 74.50840  ? 206 GLN A OE1   1 ? 
ATOM   1617 N NE2   . GLN A 1 212 ? -18.75156 8.39345   9.16692   1.000 59.84231  ? 206 GLN A NE2   1 ? 
ATOM   1618 N N     . ARG A 1 213 ? -17.73310 3.23651   10.71168  1.000 73.50070  ? 207 ARG A N     1 ? 
ATOM   1619 C CA    . ARG A 1 213 ? -18.80111 2.84678   11.62570  1.000 70.30912  ? 207 ARG A CA    1 ? 
ATOM   1620 C C     . ARG A 1 213 ? -19.24331 4.02032   12.48940  1.000 78.03806  ? 207 ARG A C     1 ? 
ATOM   1621 O O     . ARG A 1 213 ? -20.44289 4.21120   12.71312  1.000 77.33772  ? 207 ARG A O     1 ? 
ATOM   1622 C CB    . ARG A 1 213 ? -18.34836 1.67902   12.50482  1.000 73.50249  ? 207 ARG A CB    1 ? 
ATOM   1623 C CG    . ARG A 1 213 ? -19.45547 1.05662   13.34711  1.000 82.52504  ? 207 ARG A CG    1 ? 
ATOM   1624 C CD    . ARG A 1 213 ? -18.95749 0.62999   14.72285  1.000 95.04813  ? 207 ARG A CD    1 ? 
ATOM   1625 N NE    . ARG A 1 213 ? -18.22910 1.68964   15.41047  1.000 106.66185 ? 207 ARG A NE    1 ? 
ATOM   1626 C CZ    . ARG A 1 213 ? -17.35925 1.48799   16.39121  1.000 101.43697 ? 207 ARG A CZ    1 ? 
ATOM   1627 N NH1   . ARG A 1 213 ? -17.05647 0.26929   16.80788  1.000 101.20621 ? 207 ARG A NH1   1 ? 
ATOM   1628 N NH2   . ARG A 1 213 ? -16.77673 2.53579   16.96704  1.000 87.38028  ? 207 ARG A NH2   1 ? 
ATOM   1629 N N     . SER A 1 214 ? -18.29381 4.81731   12.97597  1.000 74.08932  ? 208 SER A N     1 ? 
ATOM   1630 C CA    . SER A 1 214 ? -18.59848 5.97781   13.80522  1.000 75.66076  ? 208 SER A CA    1 ? 
ATOM   1631 C C     . SER A 1 214 ? -17.60367 7.08102   13.48546  1.000 75.10754  ? 208 SER A C     1 ? 
ATOM   1632 O O     . SER A 1 214 ? -16.39342 6.88956   13.63793  1.000 72.82394  ? 208 SER A O     1 ? 
ATOM   1633 C CB    . SER A 1 214 ? -18.54817 5.62597   15.29571  1.000 78.74914  ? 208 SER A CB    1 ? 
ATOM   1634 O OG    . SER A 1 214 ? -18.55287 4.22309   15.49252  1.000 83.84780  ? 208 SER A OG    1 ? 
ATOM   1635 N N     . ALA A 1 215 ? -18.11114 8.22684   13.04058  1.000 72.05908  ? 209 ALA A N     1 ? 
ATOM   1636 C CA    . ALA A 1 215 ? -17.25205 9.37058   12.77961  1.000 63.81286  ? 209 ALA A CA    1 ? 
ATOM   1637 C C     . ALA A 1 215 ? -16.76789 9.98011   14.09004  1.000 72.02984  ? 209 ALA A C     1 ? 
ATOM   1638 O O     . ALA A 1 215 ? -17.43937 9.90667   15.12277  1.000 65.03385  ? 209 ALA A O     1 ? 
ATOM   1639 C CB    . ALA A 1 215 ? -17.99288 10.42067  11.95271  1.000 69.42285  ? 209 ALA A CB    1 ? 
ATOM   1640 N N     . GLN A 1 216 ? -15.58445 10.58666  14.04081  1.000 71.63133  ? 210 GLN A N     1 ? 
ATOM   1641 C CA    . GLN A 1 216 ? -14.97439 11.17646  15.22187  1.000 72.28846  ? 210 GLN A CA    1 ? 
ATOM   1642 C C     . GLN A 1 216 ? -14.38042 12.53099  14.86652  1.000 71.11506  ? 210 GLN A C     1 ? 
ATOM   1643 O O     . GLN A 1 216 ? -14.15961 12.85050  13.69569  1.000 75.77246  ? 210 GLN A O     1 ? 
ATOM   1644 C CB    . GLN A 1 216 ? -13.89008 10.26526  15.81179  1.000 64.86981  ? 210 GLN A CB    1 ? 
ATOM   1645 C CG    . GLN A 1 216 ? -14.42985 9.06309   16.56548  1.000 62.82419  ? 210 GLN A CG    1 ? 
ATOM   1646 C CD    . GLN A 1 216 ? -13.36125 8.36344   17.37988  1.000 74.96466  ? 210 GLN A CD    1 ? 
ATOM   1647 O OE1   . GLN A 1 216 ? -13.07950 7.18348   17.17256  1.000 79.02639  ? 210 GLN A OE1   1 ? 
ATOM   1648 N NE2   . GLN A 1 216 ? -12.75826 9.09044   18.31352  1.000 84.20258  ? 210 GLN A NE2   1 ? 
ATOM   1649 N N     . TYR A 1 217 ? -14.12662 13.32801  15.90059  1.000 70.46464  ? 211 TYR A N     1 ? 
ATOM   1650 C CA    . TYR A 1 217 ? -13.48033 14.61928  15.72407  1.000 76.68644  ? 211 TYR A CA    1 ? 
ATOM   1651 C C     . TYR A 1 217 ? -11.97719 14.43493  15.56287  1.000 69.90932  ? 211 TYR A C     1 ? 
ATOM   1652 O O     . TYR A 1 217 ? -11.35326 13.64544  16.27760  1.000 62.29859  ? 211 TYR A O     1 ? 
ATOM   1653 C CB    . TYR A 1 217 ? -13.77160 15.53190  16.91598  1.000 68.03415  ? 211 TYR A CB    1 ? 
ATOM   1654 C CG    . TYR A 1 217 ? -15.23578 15.86847  17.09586  1.000 70.57653  ? 211 TYR A CG    1 ? 
ATOM   1655 C CD1   . TYR A 1 217 ? -15.85161 16.82623  16.30075  1.000 73.42136  ? 211 TYR A CD1   1 ? 
ATOM   1656 C CD2   . TYR A 1 217 ? -16.00167 15.22922  18.06159  1.000 67.14437  ? 211 TYR A CD2   1 ? 
ATOM   1657 C CE1   . TYR A 1 217 ? -17.18884 17.13890  16.46257  1.000 72.17965  ? 211 TYR A CE1   1 ? 
ATOM   1658 C CE2   . TYR A 1 217 ? -17.33946 15.53392  18.22961  1.000 70.76008  ? 211 TYR A CE2   1 ? 
ATOM   1659 C CZ    . TYR A 1 217 ? -17.92760 16.48914  17.42836  1.000 78.89863  ? 211 TYR A CZ    1 ? 
ATOM   1660 O OH    . TYR A 1 217 ? -19.25906 16.79441  17.59422  1.000 81.21523  ? 211 TYR A OH    1 ? 
ATOM   1661 N N     . SER A 1 218 ? -11.39713 15.16607  14.61349  1.000 70.98124  ? 212 SER A N     1 ? 
ATOM   1662 C CA    . SER A 1 218 ? -9.96508  15.10018  14.35536  1.000 69.58050  ? 212 SER A CA    1 ? 
ATOM   1663 C C     . SER A 1 218 ? -9.44141  16.50167  14.08831  1.000 71.47122  ? 212 SER A C     1 ? 
ATOM   1664 O O     . SER A 1 218 ? -10.05392 17.26259  13.33383  1.000 63.67749  ? 212 SER A O     1 ? 
ATOM   1665 C CB    . SER A 1 218 ? -9.65309  14.18077  13.16922  1.000 66.83086  ? 212 SER A CB    1 ? 
ATOM   1666 O OG    . SER A 1 218 ? -8.27646  13.84566  13.13454  1.000 61.31888  ? 212 SER A OG    1 ? 
ATOM   1667 N N     . VAL A 1 219 ? -8.31228  16.83501  14.70505  1.000 71.57296  ? 213 VAL A N     1 ? 
ATOM   1668 C CA    . VAL A 1 219 ? -7.70687  18.15726  14.56962  1.000 66.14252  ? 213 VAL A CA    1 ? 
ATOM   1669 C C     . VAL A 1 219 ? -6.38512  18.01114  13.82352  1.000 63.56409  ? 213 VAL A C     1 ? 
ATOM   1670 O O     . VAL A 1 219 ? -5.81493  16.91105  13.79599  1.000 66.95156  ? 213 VAL A O     1 ? 
ATOM   1671 C CB    . VAL A 1 219 ? -7.50418  18.81572  15.94336  1.000 63.79385  ? 213 VAL A CB    1 ? 
ATOM   1672 C CG1   . VAL A 1 219 ? -8.84683  19.15698  16.57198  1.000 67.57318  ? 213 VAL A CG1   1 ? 
ATOM   1673 C CG2   . VAL A 1 219 ? -6.69965  17.90487  16.84888  1.000 67.66490  ? 213 VAL A CG2   1 ? 
ATOM   1674 N N     . PRO A 1 220 ? -5.86812  19.06964  13.19711  1.000 67.99340  ? 214 PRO A N     1 ? 
ATOM   1675 C CA    . PRO A 1 220 ? -4.56025  18.96163  12.54057  1.000 70.67920  ? 214 PRO A CA    1 ? 
ATOM   1676 C C     . PRO A 1 220 ? -3.46245  18.67575  13.55245  1.000 63.74206  ? 214 PRO A C     1 ? 
ATOM   1677 O O     . PRO A 1 220 ? -3.57913  18.99552  14.73733  1.000 62.32965  ? 214 PRO A O     1 ? 
ATOM   1678 C CB    . PRO A 1 220 ? -4.37295  20.33551  11.88413  1.000 57.54320  ? 214 PRO A CB    1 ? 
ATOM   1679 C CG    . PRO A 1 220 ? -5.74693  20.90919  11.78944  1.000 60.15600  ? 214 PRO A CG    1 ? 
ATOM   1680 C CD    . PRO A 1 220 ? -6.48133  20.39077  12.98489  1.000 65.56174  ? 214 PRO A CD    1 ? 
ATOM   1681 N N     . ILE A 1 221 ? -2.38491  18.05916  13.07136  1.000 67.39954  ? 215 ILE A N     1 ? 
ATOM   1682 C CA    . ILE A 1 221 ? -1.27576  17.69040  13.94267  1.000 68.23244  ? 215 ILE A CA    1 ? 
ATOM   1683 C C     . ILE A 1 221 ? -0.11651  18.65726  13.73674  1.000 70.23974  ? 215 ILE A C     1 ? 
ATOM   1684 O O     . ILE A 1 221 ? 0.68108   18.88510  14.65260  1.000 84.59140  ? 215 ILE A O     1 ? 
ATOM   1685 C CB    . ILE A 1 221 ? -0.84312  16.22903  13.71027  1.000 64.96081  ? 215 ILE A CB    1 ? 
ATOM   1686 C CG1   . ILE A 1 221 ? -0.15832  15.67489  14.96118  1.000 65.58247  ? 215 ILE A CG1   1 ? 
ATOM   1687 C CG2   . ILE A 1 221 ? 0.06617   16.10632  12.49295  1.000 62.15281  ? 215 ILE A CG2   1 ? 
ATOM   1688 C CD1   . ILE A 1 221 ? 0.45488   14.31043  14.76728  1.000 66.72734  ? 215 ILE A CD1   1 ? 
ATOM   1689 N N     . GLY A 1 222 ? -0.02792  19.24775  12.54570  1.000 67.97186  ? 216 GLY A N     1 ? 
ATOM   1690 C CA    . GLY A 1 222 ? 1.04524   20.17134  12.23204  1.000 58.81390  ? 216 GLY A CA    1 ? 
ATOM   1691 C C     . GLY A 1 222 ? 2.42750   19.57230  12.39544  1.000 64.01770  ? 216 GLY A C     1 ? 
ATOM   1692 O O     . GLY A 1 222 ? 3.24347   20.08249  13.16928  1.000 69.56808  ? 216 GLY A O     1 ? 
ATOM   1693 N N     . ASN A 1 223 ? 2.70288   18.48399  11.67428  1.000 56.67969  ? 217 ASN A N     1 ? 
ATOM   1694 C CA    . ASN A 1 223 ? 3.99617   17.80488  11.75790  1.000 59.47799  ? 217 ASN A CA    1 ? 
ATOM   1695 C C     . ASN A 1 223 ? 4.94966   18.44697  10.75448  1.000 60.23477  ? 217 ASN A C     1 ? 
ATOM   1696 O O     . ASN A 1 223 ? 5.22777   17.91879  9.67567   1.000 64.24969  ? 217 ASN A O     1 ? 
ATOM   1697 C CB    . ASN A 1 223 ? 3.83721   16.31031  11.51174  1.000 52.24477  ? 217 ASN A CB    1 ? 
ATOM   1698 C CG    . ASN A 1 223 ? 5.13302   15.54851  11.70859  1.000 56.22087  ? 217 ASN A CG    1 ? 
ATOM   1699 O OD1   . ASN A 1 223 ? 5.92621   15.87052  12.59305  1.000 65.31762  ? 217 ASN A OD1   1 ? 
ATOM   1700 N ND2   . ASN A 1 223 ? 5.35563   14.53334  10.88197  1.000 54.88370  ? 217 ASN A ND2   1 ? 
ATOM   1701 N N     . VAL A 1 224 ? 5.46067   19.61330  11.13052  1.000 59.96239  ? 218 VAL A N     1 ? 
ATOM   1702 C CA    . VAL A 1 224 ? 6.37196   20.36247  10.28044  1.000 64.04930  ? 218 VAL A CA    1 ? 
ATOM   1703 C C     . VAL A 1 224 ? 7.79841   19.89061  10.53091  1.000 64.17968  ? 218 VAL A C     1 ? 
ATOM   1704 O O     . VAL A 1 224 ? 8.11155   19.28599  11.55956  1.000 60.26941  ? 218 VAL A O     1 ? 
ATOM   1705 C CB    . VAL A 1 224 ? 6.24350   21.88066  10.51675  1.000 62.53842  ? 218 VAL A CB    1 ? 
ATOM   1706 C CG1   . VAL A 1 224 ? 4.82644   22.34633  10.22154  1.000 60.94914  ? 218 VAL A CG1   1 ? 
ATOM   1707 C CG2   . VAL A 1 224 ? 6.64445   22.23112  11.94189  1.000 54.75396  ? 218 VAL A CG2   1 ? 
ATOM   1708 N N     . VAL A 1 225 ? 8.67792   20.16875  9.56705   1.000 66.49826  ? 219 VAL A N     1 ? 
ATOM   1709 C CA    . VAL A 1 225 ? 10.09472  19.89086  9.75439   1.000 62.08497  ? 219 VAL A CA    1 ? 
ATOM   1710 C C     . VAL A 1 225 ? 10.65544  20.82890  10.81634  1.000 62.56996  ? 219 VAL A C     1 ? 
ATOM   1711 O O     . VAL A 1 225 ? 10.16214  21.94709  11.01878  1.000 65.43704  ? 219 VAL A O     1 ? 
ATOM   1712 C CB    . VAL A 1 225 ? 10.86309  20.03041  8.42731   1.000 68.80522  ? 219 VAL A CB    1 ? 
ATOM   1713 C CG1   . VAL A 1 225 ? 10.45052  18.93519  7.45665   1.000 63.29343  ? 219 VAL A CG1   1 ? 
ATOM   1714 C CG2   . VAL A 1 225 ? 10.62784  21.40469  7.81828   1.000 65.14513  ? 219 VAL A CG2   1 ? 
ATOM   1715 N N     . MET A 1 226 ? 11.69066  20.37009  11.51067  1.000 66.53674  ? 220 MET A N     1 ? 
ATOM   1716 C CA    . MET A 1 226 ? 12.32308  21.14992  12.56489  1.000 67.78268  ? 220 MET A CA    1 ? 
ATOM   1717 C C     . MET A 1 226 ? 13.63663  21.72482  12.05786  1.000 71.37961  ? 220 MET A C     1 ? 
ATOM   1718 O O     . MET A 1 226 ? 14.48416  20.99016  11.53897  1.000 73.17680  ? 220 MET A O     1 ? 
ATOM   1719 C CB    . MET A 1 226 ? 12.56425  20.29978  13.81170  1.000 64.40630  ? 220 MET A CB    1 ? 
ATOM   1720 C CG    . MET A 1 226 ? 11.29108  19.76729  14.43060  1.000 65.24512  ? 220 MET A CG    1 ? 
ATOM   1721 S SD    . MET A 1 226 ? 10.27411  21.06919  15.14621  1.000 72.58327  ? 220 MET A SD    1 ? 
ATOM   1722 C CE    . MET A 1 226 ? 11.04016  21.24190  16.74944  1.000 62.06187  ? 220 MET A CE    1 ? 
ATOM   1723 N N     . SER A 1 227 ? 13.80015  23.03446  12.20916  1.000 73.07326  ? 221 SER A N     1 ? 
ATOM   1724 C CA    . SER A 1 227 ? 15.02088  23.68238  11.76647  1.000 79.71715  ? 221 SER A CA    1 ? 
ATOM   1725 C C     . SER A 1 227 ? 16.12903  23.49784  12.79785  1.000 73.98237  ? 221 SER A C     1 ? 
ATOM   1726 O O     . SER A 1 227 ? 15.88570  23.17876  13.96542  1.000 78.28887  ? 221 SER A O     1 ? 
ATOM   1727 C CB    . SER A 1 227 ? 14.78476  25.17173  11.51303  1.000 81.69236  ? 221 SER A CB    1 ? 
ATOM   1728 O OG    . SER A 1 227 ? 14.80210  25.90568  12.72514  1.000 84.05633  ? 221 SER A OG    1 ? 
ATOM   1729 N N     . GLU A 1 228 ? 17.36618  23.69602  12.33613  1.000 78.55078  ? 222 GLU A N     1 ? 
ATOM   1730 C CA    . GLU A 1 228 ? 18.52545  23.65053  13.22113  1.000 81.03553  ? 222 GLU A CA    1 ? 
ATOM   1731 C C     . GLU A 1 228 ? 18.36409  24.61088  14.39096  1.000 81.07191  ? 222 GLU A C     1 ? 
ATOM   1732 O O     . GLU A 1 228 ? 18.79459  24.31671  15.51177  1.000 72.05737  ? 222 GLU A O     1 ? 
ATOM   1733 C CB    . GLU A 1 228 ? 19.80753  23.97565  12.44434  1.000 76.74435  ? 222 GLU A CB    1 ? 
ATOM   1734 C CG    . GLU A 1 228 ? 19.77404  25.23699  11.55626  1.000 98.41929  ? 222 GLU A CG    1 ? 
ATOM   1735 C CD    . GLU A 1 228 ? 18.75631  25.18229  10.42679  1.000 114.19402 ? 222 GLU A CD    1 ? 
ATOM   1736 O OE1   . GLU A 1 228 ? 18.42634  24.06600  9.97427   1.000 96.96548  ? 222 GLU A OE1   1 ? 
ATOM   1737 O OE2   . GLU A 1 228 ? 18.27726  26.25472  10.00172  1.000 100.01161 ? 222 GLU A OE2   1 ? 
ATOM   1738 N N     . THR A 1 229 ? 17.74684  25.76840  14.14842  1.000 78.64746  ? 223 THR A N     1 ? 
ATOM   1739 C CA    . THR A 1 229 ? 17.48732  26.70044  15.23842  1.000 75.87503  ? 223 THR A CA    1 ? 
ATOM   1740 C C     . THR A 1 229 ? 16.41036  26.16430  16.17268  1.000 75.59727  ? 223 THR A C     1 ? 
ATOM   1741 O O     . THR A 1 229 ? 16.52151  26.30243  17.39577  1.000 79.87120  ? 223 THR A O     1 ? 
ATOM   1742 C CB    . THR A 1 229 ? 17.09124  28.06764  14.68171  1.000 80.76361  ? 223 THR A CB    1 ? 
ATOM   1743 O OG1   . THR A 1 229 ? 17.71921  28.26435  13.40825  1.000 85.68616  ? 223 THR A OG1   1 ? 
ATOM   1744 C CG2   . THR A 1 229 ? 17.53016  29.17215  15.63106  1.000 71.07320  ? 223 THR A CG2   1 ? 
ATOM   1745 N N     . ASP A 1 230 ? 15.36718  25.54038  15.61773  1.000 79.51307  ? 224 ASP A N     1 ? 
ATOM   1746 C CA    . ASP A 1 230 ? 14.32393  24.95329  16.45429  1.000 78.92594  ? 224 ASP A CA    1 ? 
ATOM   1747 C C     . ASP A 1 230 ? 14.89904  23.88473  17.37615  1.000 70.77675  ? 224 ASP A C     1 ? 
ATOM   1748 O O     . ASP A 1 230 ? 14.62894  23.87751  18.58281  1.000 66.57189  ? 224 ASP A O     1 ? 
ATOM   1749 C CB    . ASP A 1 230 ? 13.21085  24.36800  15.58231  1.000 79.78295  ? 224 ASP A CB    1 ? 
ATOM   1750 C CG    . ASP A 1 230 ? 12.49759  25.42200  14.75626  1.000 84.52853  ? 224 ASP A CG    1 ? 
ATOM   1751 O OD1   . ASP A 1 230 ? 12.12111  26.47001  15.32182  1.000 91.02717  ? 224 ASP A OD1   1 ? 
ATOM   1752 O OD2   . ASP A 1 230 ? 12.30294  25.19760  13.54308  1.000 80.49934  ? 224 ASP A OD2   1 ? 
ATOM   1753 N N     . VAL A 1 231 ? 15.70371  22.97457  16.82278  1.000 69.51985  ? 225 VAL A N     1 ? 
ATOM   1754 C CA    . VAL A 1 231 ? 16.31151  21.92629  17.63663  1.000 72.43219  ? 225 VAL A CA    1 ? 
ATOM   1755 C C     . VAL A 1 231 ? 17.29059  22.52644  18.63806  1.000 74.81895  ? 225 VAL A C     1 ? 
ATOM   1756 O O     . VAL A 1 231 ? 17.40147  22.05619  19.77695  1.000 80.08117  ? 225 VAL A O     1 ? 
ATOM   1757 C CB    . VAL A 1 231 ? 16.98925  20.87825  16.73531  1.000 75.36836  ? 225 VAL A CB    1 ? 
ATOM   1758 C CG1   . VAL A 1 231 ? 17.49845  19.71007  17.56503  1.000 68.18042  ? 225 VAL A CG1   1 ? 
ATOM   1759 C CG2   . VAL A 1 231 ? 16.02047  20.39575  15.66680  1.000 65.86935  ? 225 VAL A CG2   1 ? 
ATOM   1760 N N     . ALA A 1 232 ? 18.01090  23.57687  18.23657  1.000 75.25129  ? 226 ALA A N     1 ? 
ATOM   1761 C CA    . ALA A 1 232 ? 18.93039  24.23076  19.16082  1.000 72.69127  ? 226 ALA A CA    1 ? 
ATOM   1762 C C     . ALA A 1 232 ? 18.18723  24.98860  20.25370  1.000 75.92862  ? 226 ALA A C     1 ? 
ATOM   1763 O O     . ALA A 1 232 ? 18.67574  25.07085  21.38601  1.000 76.69294  ? 226 ALA A O     1 ? 
ATOM   1764 C CB    . ALA A 1 232 ? 19.86612  25.17169  18.40254  1.000 72.00378  ? 226 ALA A CB    1 ? 
ATOM   1765 N N     . LYS A 1 233 ? 17.01407  25.54837  19.94228  1.000 68.08608  ? 227 LYS A N     1 ? 
ATOM   1766 C CA    . LYS A 1 233 ? 16.23106  26.21901  20.97577  1.000 73.54878  ? 227 LYS A CA    1 ? 
ATOM   1767 C C     . LYS A 1 233 ? 15.73594  25.23532  22.02750  1.000 75.40117  ? 227 LYS A C     1 ? 
ATOM   1768 O O     . LYS A 1 233 ? 15.60995  25.59765  23.20274  1.000 76.35593  ? 227 LYS A O     1 ? 
ATOM   1769 C CB    . LYS A 1 233 ? 15.04265  26.95953  20.35880  1.000 81.31411  ? 227 LYS A CB    1 ? 
ATOM   1770 C CG    . LYS A 1 233 ? 15.39923  28.21089  19.57241  1.000 83.78466  ? 227 LYS A CG    1 ? 
ATOM   1771 C CD    . LYS A 1 233 ? 16.17202  29.20765  20.41583  1.000 99.41345  ? 227 LYS A CD    1 ? 
ATOM   1772 C CE    . LYS A 1 233 ? 17.45511  29.62067  19.71424  1.000 92.03020  ? 227 LYS A CE    1 ? 
ATOM   1773 N NZ    . LYS A 1 233 ? 18.15801  30.71983  20.42988  1.000 85.13601  ? 227 LYS A NZ    1 ? 
ATOM   1774 N N     . ILE A 1 234 ? 15.45202  23.99553  21.62799  1.000 70.34294  ? 228 ILE A N     1 ? 
ATOM   1775 C CA    . ILE A 1 234 ? 14.95344  22.99714  22.56835  1.000 68.69673  ? 228 ILE A CA    1 ? 
ATOM   1776 C C     . ILE A 1 234 ? 16.08413  22.44920  23.42904  1.000 69.82512  ? 228 ILE A C     1 ? 
ATOM   1777 O O     . ILE A 1 234 ? 15.96836  22.37504  24.65780  1.000 68.32653  ? 228 ILE A O     1 ? 
ATOM   1778 C CB    . ILE A 1 234 ? 14.22432  21.87004  21.81220  1.000 71.44817  ? 228 ILE A CB    1 ? 
ATOM   1779 C CG1   . ILE A 1 234 ? 12.94223  22.39578  21.16604  1.000 70.55728  ? 228 ILE A CG1   1 ? 
ATOM   1780 C CG2   . ILE A 1 234 ? 13.93495  20.69399  22.73107  1.000 63.24174  ? 228 ILE A CG2   1 ? 
ATOM   1781 C CD1   . ILE A 1 234 ? 12.60755  21.71738  19.86750  1.000 61.11938  ? 228 ILE A CD1   1 ? 
ATOM   1782 N N     . LYS A 1 235 ? 17.19485  22.05889  22.79872  1.000 64.78847  ? 229 LYS A N     1 ? 
ATOM   1783 C CA    . LYS A 1 235 ? 18.27976  21.41975  23.53664  1.000 74.04777  ? 229 LYS A CA    1 ? 
ATOM   1784 C C     . LYS A 1 235 ? 18.98745  22.39503  24.46910  1.000 70.43127  ? 229 LYS A C     1 ? 
ATOM   1785 O O     . LYS A 1 235 ? 19.48721  21.98718  25.52379  1.000 71.15756  ? 229 LYS A O     1 ? 
ATOM   1786 C CB    . LYS A 1 235 ? 19.27154  20.79001  22.56042  1.000 66.70852  ? 229 LYS A CB    1 ? 
ATOM   1787 C CG    . LYS A 1 235 ? 18.70470  19.59840  21.80491  1.000 60.60411  ? 229 LYS A CG    1 ? 
ATOM   1788 C CD    . LYS A 1 235 ? 19.58948  19.20509  20.63631  1.000 57.24949  ? 229 LYS A CD    1 ? 
ATOM   1789 C CE    . LYS A 1 235 ? 19.33614  17.76616  20.22006  1.000 61.73951  ? 229 LYS A CE    1 ? 
ATOM   1790 N NZ    . LYS A 1 235 ? 20.09159  17.40220  18.99050  1.000 63.27539  ? 229 LYS A NZ    1 ? 
ATOM   1791 N N     . GLU A 1 236 ? 19.03827  23.67793  24.10763  1.000 72.43920  ? 230 GLU A N     1 ? 
ATOM   1792 C CA    . GLU A 1 236 ? 19.57341  24.69865  25.00201  1.000 80.47346  ? 230 GLU A CA    1 ? 
ATOM   1793 C C     . GLU A 1 236 ? 18.69629  24.92327  26.22328  1.000 85.62453  ? 230 GLU A C     1 ? 
ATOM   1794 O O     . GLU A 1 236 ? 19.07169  25.70975  27.10092  1.000 84.48035  ? 230 GLU A O     1 ? 
ATOM   1795 C CB    . GLU A 1 236 ? 19.73897  26.02236  24.25364  1.000 83.67396  ? 230 GLU A CB    1 ? 
ATOM   1796 C CG    . GLU A 1 236 ? 21.07557  26.19764  23.55772  1.000 90.22379  ? 230 GLU A CG    1 ? 
ATOM   1797 C CD    . GLU A 1 236 ? 21.14206  27.48344  22.75586  1.000 104.12110 ? 230 GLU A CD    1 ? 
ATOM   1798 O OE1   . GLU A 1 236 ? 20.59106  28.50460  23.21946  1.000 89.05461  ? 230 GLU A OE1   1 ? 
ATOM   1799 O OE2   . GLU A 1 236 ? 21.73944  27.47212  21.65933  1.000 103.82464 ? 230 GLU A OE2   1 ? 
ATOM   1800 N N     . ASN A 1 237 ? 17.54928  24.24913  26.30105  1.000 72.18493  ? 231 ASN A N     1 ? 
ATOM   1801 C CA    . ASN A 1 237 ? 16.56084  24.51840  27.33574  1.000 74.76689  ? 231 ASN A CA    1 ? 
ATOM   1802 C C     . ASN A 1 237 ? 15.84450  23.22718  27.71462  1.000 80.51855  ? 231 ASN A C     1 ? 
ATOM   1803 O O     . ASN A 1 237 ? 14.62561  23.21067  27.91332  1.000 82.96496  ? 231 ASN A O     1 ? 
ATOM   1804 C CB    . ASN A 1 237 ? 15.56046  25.57856  26.86811  1.000 79.64120  ? 231 ASN A CB    1 ? 
ATOM   1805 C CG    . ASN A 1 237 ? 15.06205  26.45287  27.99237  1.000 92.16808  ? 231 ASN A CG    1 ? 
ATOM   1806 O OD1   . ASN A 1 237 ? 13.85650  26.61761  28.17188  1.000 96.03840  ? 231 ASN A OD1   1 ? 
ATOM   1807 N ND2   . ASN A 1 237 ? 15.98663  27.02169  28.75848  1.000 95.10288  ? 231 ASN A ND2   1 ? 
ATOM   1808 N N     . TYR A 1 238 ? 16.59700  22.13122  27.82407  1.000 76.18492  ? 232 TYR A N     1 ? 
ATOM   1809 C CA    . TYR A 1 238 ? 16.00213  20.80689  27.96578  1.000 76.02006  ? 232 TYR A CA    1 ? 
ATOM   1810 C C     . TYR A 1 238 ? 15.68970  20.45360  29.41555  1.000 79.12373  ? 232 TYR A C     1 ? 
ATOM   1811 O O     . TYR A 1 238 ? 14.61862  19.90857  29.70159  1.000 80.60360  ? 232 TYR A O     1 ? 
ATOM   1812 C CB    . TYR A 1 238 ? 16.92150  19.74954  27.35463  1.000 81.46826  ? 232 TYR A CB    1 ? 
ATOM   1813 C CG    . TYR A 1 238 ? 16.19637  18.84881  26.38887  1.000 70.42652  ? 232 TYR A CG    1 ? 
ATOM   1814 C CD1   . TYR A 1 238 ? 14.90530  18.41299  26.65801  1.000 70.42221  ? 232 TYR A CD1   1 ? 
ATOM   1815 C CD2   . TYR A 1 238 ? 16.78877  18.45159  25.19987  1.000 73.01442  ? 232 TYR A CD2   1 ? 
ATOM   1816 C CE1   . TYR A 1 238 ? 14.23062  17.59609  25.77603  1.000 72.46461  ? 232 TYR A CE1   1 ? 
ATOM   1817 C CE2   . TYR A 1 238 ? 16.12221  17.63555  24.31169  1.000 74.89915  ? 232 TYR A CE2   1 ? 
ATOM   1818 C CZ    . TYR A 1 238 ? 14.84236  17.21011  24.60464  1.000 73.25714  ? 232 TYR A CZ    1 ? 
ATOM   1819 O OH    . TYR A 1 238 ? 14.16386  16.39519  23.72858  1.000 72.54708  ? 232 TYR A OH    1 ? 
ATOM   1820 N N     . ASP A 1 239 ? 16.61511  20.73908  30.33571  1.000 78.37075  ? 233 ASP A N     1 ? 
ATOM   1821 C CA    . ASP A 1 239 ? 16.32852  20.63247  31.76426  1.000 79.47434  ? 233 ASP A CA    1 ? 
ATOM   1822 C C     . ASP A 1 239 ? 15.06385  21.42165  32.08985  1.000 69.43231  ? 233 ASP A C     1 ? 
ATOM   1823 O O     . ASP A 1 239 ? 14.30099  21.05835  32.99066  1.000 63.99924  ? 233 ASP A O     1 ? 
ATOM   1824 C CB    . ASP A 1 239 ? 17.50517  21.14300  32.60715  1.000 79.15784  ? 233 ASP A CB    1 ? 
ATOM   1825 C CG    . ASP A 1 239 ? 18.60460  20.10496  32.78829  1.000 85.31425  ? 233 ASP A CG    1 ? 
ATOM   1826 O OD1   . ASP A 1 239 ? 18.78707  19.61155  33.92472  1.000 106.73637 ? 233 ASP A OD1   1 ? 
ATOM   1827 O OD2   . ASP A 1 239 ? 19.29548  19.79390  31.80010  1.000 106.98308 ? 233 ASP A OD2   1 ? 
ATOM   1828 N N     . GLN A 1 240 ? 14.83883  22.50266  31.33990  1.000 78.91484  ? 234 GLN A N     1 ? 
ATOM   1829 C CA    . GLN A 1 240 ? 13.64563  23.32452  31.50769  1.000 84.80878  ? 234 GLN A CA    1 ? 
ATOM   1830 C C     . GLN A 1 240 ? 12.38253  22.57892  31.09211  1.000 86.86003  ? 234 GLN A C     1 ? 
ATOM   1831 O O     . GLN A 1 240 ? 11.41194  22.51720  31.85522  1.000 83.38424  ? 234 GLN A O     1 ? 
ATOM   1832 C CB    . GLN A 1 240 ? 13.79742  24.61491  30.70005  1.000 92.52445  ? 234 GLN A CB    1 ? 
ATOM   1833 C CG    . GLN A 1 240 ? 12.71487  25.66936  30.92809  1.000 95.83783  ? 234 GLN A CG    1 ? 
ATOM   1834 C CD    . GLN A 1 240 ? 12.25206  25.80097  32.36546  1.000 101.00363 ? 234 GLN A CD    1 ? 
ATOM   1835 O OE1   . GLN A 1 240 ? 13.00287  25.55998  33.30688  1.000 96.61704  ? 234 GLN A OE1   1 ? 
ATOM   1836 N NE2   . GLN A 1 240 ? 10.99619  26.18888  32.53851  1.000 106.78710 ? 234 GLN A NE2   1 ? 
ATOM   1837 N N     . ILE A 1 241 ? 12.37313  22.00639  29.88305  1.000 79.36016  ? 235 ILE A N     1 ? 
ATOM   1838 C CA    . ILE A 1 241 ? 11.14646  21.41166  29.35240  1.000 78.98255  ? 235 ILE A CA    1 ? 
ATOM   1839 C C     . ILE A 1 241 ? 10.68308  20.24632  30.21557  1.000 74.91920  ? 235 ILE A C     1 ? 
ATOM   1840 O O     . ILE A 1 241 ? 9.47648   20.01583  30.36925  1.000 78.51273  ? 235 ILE A O     1 ? 
ATOM   1841 C CB    . ILE A 1 241 ? 11.35052  20.98270  27.88529  1.000 76.32851  ? 235 ILE A CB    1 ? 
ATOM   1842 C CG1   . ILE A 1 241 ? 11.73012  22.18836  27.02842  1.000 75.62862  ? 235 ILE A CG1   1 ? 
ATOM   1843 C CG2   . ILE A 1 241 ? 10.09017  20.33892  27.33117  1.000 70.30045  ? 235 ILE A CG2   1 ? 
ATOM   1844 C CD1   . ILE A 1 241 ? 12.52802  21.83250  25.80568  1.000 76.58455  ? 235 ILE A CD1   1 ? 
ATOM   1845 N N     . TRP A 1 242 ? 11.61991  19.51388  30.81637  1.000 72.58977  ? 236 TRP A N     1 ? 
ATOM   1846 C CA    . TRP A 1 242 ? 11.24103  18.33847  31.58993  1.000 74.04976  ? 236 TRP A CA    1 ? 
ATOM   1847 C C     . TRP A 1 242 ? 10.64972  18.71664  32.94136  1.000 71.32926  ? 236 TRP A C     1 ? 
ATOM   1848 O O     . TRP A 1 242 ? 9.73489   18.04199  33.42485  1.000 71.33061  ? 236 TRP A O     1 ? 
ATOM   1849 C CB    . TRP A 1 242 ? 12.44521  17.41321  31.76074  1.000 61.04054  ? 236 TRP A CB    1 ? 
ATOM   1850 C CG    . TRP A 1 242 ? 12.73062  16.62714  30.52192  1.000 69.09806  ? 236 TRP A CG    1 ? 
ATOM   1851 C CD1   . TRP A 1 242 ? 13.85473  16.68777  29.75276  1.000 70.67992  ? 236 TRP A CD1   1 ? 
ATOM   1852 C CD2   . TRP A 1 242 ? 11.86412  15.67452  29.89281  1.000 70.41219  ? 236 TRP A CD2   1 ? 
ATOM   1853 N NE1   . TRP A 1 242 ? 13.74573  15.82730  28.68700  1.000 73.41022  ? 236 TRP A NE1   1 ? 
ATOM   1854 C CE2   . TRP A 1 242 ? 12.53242  15.19398  28.74980  1.000 69.96151  ? 236 TRP A CE2   1 ? 
ATOM   1855 C CE3   . TRP A 1 242 ? 10.58979  15.17871  30.18773  1.000 70.88845  ? 236 TRP A CE3   1 ? 
ATOM   1856 C CZ2   . TRP A 1 242 ? 11.97149  14.24032  27.90340  1.000 67.78978  ? 236 TRP A CZ2   1 ? 
ATOM   1857 C CZ3   . TRP A 1 242 ? 10.03414  14.23442  29.34584  1.000 59.57746  ? 236 TRP A CZ3   1 ? 
ATOM   1858 C CH2   . TRP A 1 242 ? 10.72413  13.77488  28.21739  1.000 65.34596  ? 236 TRP A CH2   1 ? 
ATOM   1859 N N     . GLU A 1 243 ? 11.15143  19.78678  33.56409  1.000 78.75186  ? 237 GLU A N     1 ? 
ATOM   1860 C CA    . GLU A 1 243 ? 10.57523  20.23551  34.82833  1.000 79.94510  ? 237 GLU A CA    1 ? 
ATOM   1861 C C     . GLU A 1 243 ? 9.11098   20.62072  34.65622  1.000 78.56915  ? 237 GLU A C     1 ? 
ATOM   1862 O O     . GLU A 1 243 ? 8.28945   20.38799  35.55108  1.000 81.87783  ? 237 GLU A O     1 ? 
ATOM   1863 C CB    . GLU A 1 243 ? 11.37988  21.40878  35.38863  1.000 89.54318  ? 237 GLU A CB    1 ? 
ATOM   1864 C CG    . GLU A 1 243 ? 12.64197  21.00689  36.14393  1.000 114.48060 ? 237 GLU A CG    1 ? 
ATOM   1865 C CD    . GLU A 1 243 ? 12.43238  19.81391  37.06051  1.000 111.06815 ? 237 GLU A CD    1 ? 
ATOM   1866 O OE1   . GLU A 1 243 ? 11.50952  19.85778  37.90188  1.000 110.42854 ? 237 GLU A OE1   1 ? 
ATOM   1867 O OE2   . GLU A 1 243 ? 13.19529  18.83190  36.94147  1.000 106.13263 ? 237 GLU A OE2   1 ? 
ATOM   1868 N N     . ASN A 1 244 ? 8.76407   21.20534  33.50643  1.000 76.25465  ? 238 ASN A N     1 ? 
ATOM   1869 C CA    . ASN A 1 244 ? 7.36549   21.50811  33.22359  1.000 72.16498  ? 238 ASN A CA    1 ? 
ATOM   1870 C C     . ASN A 1 244 ? 6.54689   20.23918  33.02594  1.000 73.13675  ? 238 ASN A C     1 ? 
ATOM   1871 O O     . ASN A 1 244 ? 5.34185   20.23208  33.30183  1.000 75.15849  ? 238 ASN A O     1 ? 
ATOM   1872 C CB    . ASN A 1 244 ? 7.25880   22.40142  31.98737  1.000 74.90495  ? 238 ASN A CB    1 ? 
ATOM   1873 C CG    . ASN A 1 244 ? 7.97810   23.72410  32.15936  1.000 81.91767  ? 238 ASN A CG    1 ? 
ATOM   1874 O OD1   . ASN A 1 244 ? 8.12494   24.22415  33.27438  1.000 80.93426  ? 238 ASN A OD1   1 ? 
ATOM   1875 N ND2   . ASN A 1 244 ? 8.43278   24.29824  31.05165  1.000 85.11832  ? 238 ASN A ND2   1 ? 
ATOM   1876 N N     . VAL A 1 245 ? 7.17850   19.16294  32.55268  1.000 68.27666  ? 239 VAL A N     1 ? 
ATOM   1877 C CA    . VAL A 1 245 ? 6.45995   17.91125  32.33257  1.000 67.99420  ? 239 VAL A CA    1 ? 
ATOM   1878 C C     . VAL A 1 245 ? 6.01628   17.31053  33.66150  1.000 72.43631  ? 239 VAL A C     1 ? 
ATOM   1879 O O     . VAL A 1 245 ? 4.86252   16.89296  33.81786  1.000 67.61874  ? 239 VAL A O     1 ? 
ATOM   1880 C CB    . VAL A 1 245 ? 7.32968   16.92830  31.52778  1.000 66.44649  ? 239 VAL A CB    1 ? 
ATOM   1881 C CG1   . VAL A 1 245 ? 6.72872   15.53465  31.56286  1.000 63.81357  ? 239 VAL A CG1   1 ? 
ATOM   1882 C CG2   . VAL A 1 245 ? 7.48339   17.40802  30.09308  1.000 65.91671  ? 239 VAL A CG2   1 ? 
ATOM   1883 N N     . TRP A 1 246 ? 6.92327   17.26184  34.64178  1.000 68.48206  ? 240 TRP A N     1 ? 
ATOM   1884 C CA    . TRP A 1 246 ? 6.56769   16.72623  35.95121  1.000 73.00799  ? 240 TRP A CA    1 ? 
ATOM   1885 C C     . TRP A 1 246 ? 5.60932   17.63653  36.70793  1.000 77.22562  ? 240 TRP A C     1 ? 
ATOM   1886 O O     . TRP A 1 246 ? 4.95426   17.17829  37.65022  1.000 84.03196  ? 240 TRP A O     1 ? 
ATOM   1887 C CB    . TRP A 1 246 ? 7.82425   16.48540  36.79251  1.000 80.22639  ? 240 TRP A CB    1 ? 
ATOM   1888 C CG    . TRP A 1 246 ? 8.96982   15.88046  36.03308  1.000 80.15159  ? 240 TRP A CG    1 ? 
ATOM   1889 C CD1   . TRP A 1 246 ? 10.21040  16.42083  35.85630  1.000 83.27395  ? 240 TRP A CD1   1 ? 
ATOM   1890 C CD2   . TRP A 1 246 ? 8.98241   14.61816  35.35350  1.000 80.56363  ? 240 TRP A CD2   1 ? 
ATOM   1891 N NE1   . TRP A 1 246 ? 10.99295  15.57692  35.10608  1.000 86.04330  ? 240 TRP A NE1   1 ? 
ATOM   1892 C CE2   . TRP A 1 246 ? 10.26293  14.46290  34.78527  1.000 81.78777  ? 240 TRP A CE2   1 ? 
ATOM   1893 C CE3   . TRP A 1 246 ? 8.03570   13.60540  35.16942  1.000 81.35778  ? 240 TRP A CE3   1 ? 
ATOM   1894 C CZ2   . TRP A 1 246 ? 10.62045  13.33692  34.04629  1.000 79.43684  ? 240 TRP A CZ2   1 ? 
ATOM   1895 C CZ3   . TRP A 1 246 ? 8.39277   12.48846  34.43508  1.000 80.13971  ? 240 TRP A CZ3   1 ? 
ATOM   1896 C CH2   . TRP A 1 246 ? 9.67385   12.36343  33.88295  1.000 79.05143  ? 240 TRP A CH2   1 ? 
ATOM   1897 N N     . ASN A 1 247 ? 5.51393   18.90833  36.32202  1.000 74.63955  ? 241 ASN A N     1 ? 
ATOM   1898 C CA    . ASN A 1 247 ? 4.58775   19.84124  36.94843  1.000 78.96773  ? 241 ASN A CA    1 ? 
ATOM   1899 C C     . ASN A 1 247 ? 3.26046   19.94927  36.21131  1.000 81.99338  ? 241 ASN A C     1 ? 
ATOM   1900 O O     . ASN A 1 247 ? 2.31360   20.52825  36.75455  1.000 83.59624  ? 241 ASN A O     1 ? 
ATOM   1901 C CB    . ASN A 1 247 ? 5.22297   21.23170  37.05131  1.000 79.22327  ? 241 ASN A CB    1 ? 
ATOM   1902 C CG    . ASN A 1 247 ? 5.90346   21.46296  38.38518  1.000 94.97801  ? 241 ASN A CG    1 ? 
ATOM   1903 O OD1   . ASN A 1 247 ? 6.47763   20.54424  38.97019  1.000 92.73680  ? 241 ASN A OD1   1 ? 
ATOM   1904 N ND2   . ASN A 1 247 ? 5.83817   22.69493  38.87663  1.000 106.24244 ? 241 ASN A ND2   1 ? 
ATOM   1905 N N     . SER A 1 248 ? 3.16836   19.41695  34.99830  1.000 81.79008  ? 242 SER A N     1 ? 
ATOM   1906 C CA    . SER A 1 248 ? 1.93052   19.44656  34.23868  1.000 70.44173  ? 242 SER A CA    1 ? 
ATOM   1907 C C     . SER A 1 248 ? 1.08704   18.21099  34.54084  1.000 72.22440  ? 242 SER A C     1 ? 
ATOM   1908 O O     . SER A 1 248 ? 1.54695   17.23832  35.14364  1.000 75.56166  ? 242 SER A O     1 ? 
ATOM   1909 C CB    . SER A 1 248 ? 2.22297   19.53697  32.74145  1.000 70.37399  ? 242 SER A CB    1 ? 
ATOM   1910 O OG    . SER A 1 248 ? 2.92470   18.39082  32.29317  1.000 65.82299  ? 242 SER A OG    1 ? 
ATOM   1911 N N     . ALA A 1 249 ? -0.17203  18.26329  34.10915  1.000 73.54654  ? 243 ALA A N     1 ? 
ATOM   1912 C CA    . ALA A 1 249 ? -1.08719  17.14202  34.27161  1.000 73.64295  ? 243 ALA A CA    1 ? 
ATOM   1913 C C     . ALA A 1 249 ? -0.98339  16.13136  33.13918  1.000 70.81376  ? 243 ALA A C     1 ? 
ATOM   1914 O O     . ALA A 1 249 ? -1.17636  14.93183  33.36929  1.000 78.94840  ? 243 ALA A O     1 ? 
ATOM   1915 C CB    . ALA A 1 249 ? -2.52972  17.64831  34.37001  1.000 74.13067  ? 243 ALA A CB    1 ? 
ATOM   1916 N N     . LEU A 1 250 ? -0.67820  16.58598  31.92359  1.000 71.43864  ? 244 LEU A N     1 ? 
ATOM   1917 C CA    . LEU A 1 250 ? -0.64590  15.71191  30.75969  1.000 70.24945  ? 244 LEU A CA    1 ? 
ATOM   1918 C C     . LEU A 1 250 ? 0.76199   15.36431  30.29863  1.000 69.43085  ? 244 LEU A C     1 ? 
ATOM   1919 O O     . LEU A 1 250 ? 0.92865   14.38913  29.55786  1.000 72.37561  ? 244 LEU A O     1 ? 
ATOM   1920 C CB    . LEU A 1 250 ? -1.40765  16.35834  29.59762  1.000 62.01712  ? 244 LEU A CB    1 ? 
ATOM   1921 C CG    . LEU A 1 250 ? -2.88267  16.65322  29.86938  1.000 65.14445  ? 244 LEU A CG    1 ? 
ATOM   1922 C CD1   . LEU A 1 250 ? -3.39419  17.70618  28.90445  1.000 69.55548  ? 244 LEU A CD1   1 ? 
ATOM   1923 C CD2   . LEU A 1 250 ? -3.71387  15.38232  29.77535  1.000 78.48735  ? 244 LEU A CD2   1 ? 
ATOM   1924 N N     . GLY A 1 251 ? 1.76972   16.13012  30.70998  1.000 66.16100  ? 245 GLY A N     1 ? 
ATOM   1925 C CA    . GLY A 1 251 ? 3.12857   15.84888  30.29396  1.000 64.99417  ? 245 GLY A CA    1 ? 
ATOM   1926 C C     . GLY A 1 251 ? 3.39416   16.04327  28.82014  1.000 57.06474  ? 245 GLY A C     1 ? 
ATOM   1927 O O     . GLY A 1 251 ? 4.37470   15.50424  28.30140  1.000 65.01909  ? 245 GLY A O     1 ? 
ATOM   1928 N N     . TYR A 1 252 ? 2.54497   16.79782  28.12540  1.000 72.05220  ? 246 TYR A N     1 ? 
ATOM   1929 C CA    . TYR A 1 252 ? 2.70785   17.05975  26.70273  1.000 70.63609  ? 246 TYR A CA    1 ? 
ATOM   1930 C C     . TYR A 1 252 ? 3.36290   18.40730  26.42750  1.000 71.19062  ? 246 TYR A C     1 ? 
ATOM   1931 O O     . TYR A 1 252 ? 3.39275   18.84592  25.27326  1.000 80.57156  ? 246 TYR A O     1 ? 
ATOM   1932 C CB    . TYR A 1 252 ? 1.35271   16.98539  25.99437  1.000 64.87147  ? 246 TYR A CB    1 ? 
ATOM   1933 C CG    . TYR A 1 252 ? 0.91233   15.58130  25.64164  1.000 73.25876  ? 246 TYR A CG    1 ? 
ATOM   1934 C CD1   . TYR A 1 252 ? 1.26911   15.00311  24.43059  1.000 82.69336  ? 246 TYR A CD1   1 ? 
ATOM   1935 C CD2   . TYR A 1 252 ? 0.13588   14.83564  26.51882  1.000 78.31851  ? 246 TYR A CD2   1 ? 
ATOM   1936 C CE1   . TYR A 1 252 ? 0.86561   13.72112  24.10422  1.000 77.80384  ? 246 TYR A CE1   1 ? 
ATOM   1937 C CE2   . TYR A 1 252 ? -0.27078  13.55252  26.20131  1.000 81.68802  ? 246 TYR A CE2   1 ? 
ATOM   1938 C CZ    . TYR A 1 252 ? 0.09740   13.00072  24.99297  1.000 76.85320  ? 246 TYR A CZ    1 ? 
ATOM   1939 O OH    . TYR A 1 252 ? -0.30465  11.72468  24.67160  1.000 83.21620  ? 246 TYR A OH    1 ? 
ATOM   1940 N N     . GLY A 1 253 ? 3.89391   19.06763  27.45487  1.000 68.34742  ? 247 GLY A N     1 ? 
ATOM   1941 C CA    . GLY A 1 253 ? 4.48498   20.37774  27.26992  1.000 66.81780  ? 247 GLY A CA    1 ? 
ATOM   1942 C C     . GLY A 1 253 ? 3.49502   21.46806  26.93873  1.000 68.13496  ? 247 GLY A C     1 ? 
ATOM   1943 O O     . GLY A 1 253 ? 3.87988   22.49155  26.36756  1.000 75.03627  ? 247 GLY A O     1 ? 
ATOM   1944 N N     . LEU A 1 254 ? 2.22742   21.27927  27.28744  1.000 70.20497  ? 248 LEU A N     1 ? 
ATOM   1945 C CA    . LEU A 1 254 ? 1.17199   22.21664  26.94159  1.000 72.28517  ? 248 LEU A CA    1 ? 
ATOM   1946 C C     . LEU A 1 254 ? 1.01599   23.28311  28.01720  1.000 74.57319  ? 248 LEU A C     1 ? 
ATOM   1947 O O     . LEU A 1 254 ? 1.30337   23.05674  29.19574  1.000 70.81498  ? 248 LEU A O     1 ? 
ATOM   1948 C CB    . LEU A 1 254 ? -0.15601  21.48106  26.75606  1.000 68.85985  ? 248 LEU A CB    1 ? 
ATOM   1949 C CG    . LEU A 1 254 ? -0.58340  21.07016  25.34659  1.000 74.08617  ? 248 LEU A CG    1 ? 
ATOM   1950 C CD1   . LEU A 1 254 ? 0.59676   20.57902  24.52403  1.000 66.90491  ? 248 LEU A CD1   1 ? 
ATOM   1951 C CD2   . LEU A 1 254 ? -1.64752  19.99540  25.44340  1.000 70.19708  ? 248 LEU A CD2   1 ? 
ATOM   1952 N N     . ASN A 1 255 ? 0.55256   24.45812  27.59218  1.000 78.97416  ? 249 ASN A N     1 ? 
ATOM   1953 C CA    . ASN A 1 255 ? 0.16391   25.52851  28.50775  1.000 79.33580  ? 249 ASN A CA    1 ? 
ATOM   1954 C C     . ASN A 1 255 ? -1.23460  25.20229  29.02291  1.000 78.71353  ? 249 ASN A C     1 ? 
ATOM   1955 O O     . ASN A 1 255 ? -2.24242  25.76699  28.59006  1.000 77.03954  ? 249 ASN A O     1 ? 
ATOM   1956 C CB    . ASN A 1 255 ? 0.20469   26.87779  27.80317  1.000 88.67339  ? 249 ASN A CB    1 ? 
ATOM   1957 C CG    . ASN A 1 255 ? 1.61641   27.35547  27.53947  1.000 109.24194 ? 249 ASN A CG    1 ? 
ATOM   1958 O OD1   . ASN A 1 255 ? 2.52940   27.10549  28.32616  1.000 119.41634 ? 249 ASN A OD1   1 ? 
ATOM   1959 N ND2   . ASN A 1 255 ? 1.80679   28.03173  26.41366  1.000 112.52030 ? 249 ASN A ND2   1 ? 
ATOM   1960 N N     . GLU A 1 256 ? -1.28951  24.24984  29.95576  1.000 78.35278  ? 250 GLU A N     1 ? 
ATOM   1961 C CA    . GLU A 1 256 ? -2.55829  23.75967  30.48272  1.000 74.52917  ? 250 GLU A CA    1 ? 
ATOM   1962 C C     . GLU A 1 256 ? -3.40668  24.90989  31.00887  1.000 70.63415  ? 250 GLU A C     1 ? 
ATOM   1963 O O     . GLU A 1 256 ? -3.10080  25.49733  32.05128  1.000 80.38924  ? 250 GLU A O     1 ? 
ATOM   1964 C CB    . GLU A 1 256 ? -2.31379  22.71711  31.57374  1.000 68.10343  ? 250 GLU A CB    1 ? 
ATOM   1965 C CG    . GLU A 1 256 ? -2.21128  21.29840  31.03786  1.000 74.03755  ? 250 GLU A CG    1 ? 
ATOM   1966 C CD    . GLU A 1 256 ? -1.14298  20.48597  31.73929  1.000 79.84636  ? 250 GLU A CD    1 ? 
ATOM   1967 O OE1   . GLU A 1 256 ? -0.80227  20.82060  32.89333  1.000 76.20595  ? 250 GLU A OE1   1 ? 
ATOM   1968 O OE2   . GLU A 1 256 ? -0.64275  19.51390  31.13487  1.000 73.29683  ? 250 GLU A OE2   1 ? 
ATOM   1969 N N     . SER A 1 257 ? -4.47065  25.23643  30.28244  1.000 76.57196  ? 251 SER A N     1 ? 
ATOM   1970 C CA    . SER A 1 257 ? -5.25399  26.42858  30.56061  1.000 77.53557  ? 251 SER A CA    1 ? 
ATOM   1971 C C     . SER A 1 257 ? -6.22720  26.20189  31.71006  1.000 75.90517  ? 251 SER A C     1 ? 
ATOM   1972 O O     . SER A 1 257 ? -6.66800  25.07961  31.97432  1.000 76.57285  ? 251 SER A O     1 ? 
ATOM   1973 C CB    . SER A 1 257 ? -6.02583  26.86131  29.31305  1.000 75.02901  ? 251 SER A CB    1 ? 
ATOM   1974 O OG    . SER A 1 257 ? -7.05042  27.78461  29.64005  1.000 82.21424  ? 251 SER A OG    1 ? 
ATOM   1975 N N     . THR A 1 258 ? -6.55237  27.29420  32.40036  1.000 80.23072  ? 252 THR A N     1 ? 
ATOM   1976 C CA    . THR A 1 258 ? -7.60845  27.31425  33.40008  1.000 81.37315  ? 252 THR A CA    1 ? 
ATOM   1977 C C     . THR A 1 258 ? -8.72169  28.28560  33.03816  1.000 84.55574  ? 252 THR A C     1 ? 
ATOM   1978 O O     . THR A 1 258 ? -9.70596  28.38539  33.78039  1.000 83.39459  ? 252 THR A O     1 ? 
ATOM   1979 C CB    . THR A 1 258 ? -7.04106  27.67740  34.77970  1.000 74.74795  ? 252 THR A CB    1 ? 
ATOM   1980 O OG1   . THR A 1 258 ? -6.51203  29.00882  34.74534  1.000 69.60139  ? 252 THR A OG1   1 ? 
ATOM   1981 C CG2   . THR A 1 258 ? -5.93808  26.70731  35.17639  1.000 66.86996  ? 252 THR A CG2   1 ? 
ATOM   1982 N N     . LEU A 1 259 ? -8.59185  28.99992  31.92730  1.000 82.71718  ? 253 LEU A N     1 ? 
ATOM   1983 C CA    . LEU A 1 259 ? -9.61807  29.94564  31.51083  1.000 85.78778  ? 253 LEU A CA    1 ? 
ATOM   1984 C C     . LEU A 1 259 ? -10.87106 29.19342  31.07661  1.000 92.06788  ? 253 LEU A C     1 ? 
ATOM   1985 O O     . LEU A 1 259 ? -10.77801 28.25627  30.27594  1.000 92.19267  ? 253 LEU A O     1 ? 
ATOM   1986 C CB    . LEU A 1 259 ? -9.09590  30.81295  30.36746  1.000 83.54037  ? 253 LEU A CB    1 ? 
ATOM   1987 C CG    . LEU A 1 259 ? -10.08020 31.77158  29.69778  1.000 81.77219  ? 253 LEU A CG    1 ? 
ATOM   1988 C CD1   . LEU A 1 259 ? -10.08030 33.11834  30.40440  1.000 80.94722  ? 253 LEU A CD1   1 ? 
ATOM   1989 C CD2   . LEU A 1 259 ? -9.74978  31.93235  28.22120  1.000 77.66338  ? 253 LEU A CD2   1 ? 
ATOM   1990 N N     . PRO A 1 260 ? -12.04726 29.55951  31.57627  1.000 93.61476  ? 254 PRO A N     1 ? 
ATOM   1991 C CA    . PRO A 1 260 ? -13.27003 28.86063  31.17233  1.000 94.11071  ? 254 PRO A CA    1 ? 
ATOM   1992 C C     . PRO A 1 260 ? -13.71143 29.25311  29.77131  1.000 101.41871 ? 254 PRO A C     1 ? 
ATOM   1993 O O     . PRO A 1 260 ? -13.45029 30.35898  29.29173  1.000 100.89912 ? 254 PRO A O     1 ? 
ATOM   1994 C CB    . PRO A 1 260 ? -14.30006 29.30296  32.22231  1.000 90.77054  ? 254 PRO A CB    1 ? 
ATOM   1995 C CG    . PRO A 1 260 ? -13.51625 30.04369  33.28392  1.000 91.54913  ? 254 PRO A CG    1 ? 
ATOM   1996 C CD    . PRO A 1 260 ? -12.31331 30.58697  32.59295  1.000 93.64113  ? 254 PRO A CD    1 ? 
ATOM   1997 N N     . THR A 1 261 ? -14.40464 28.31671  29.11948  1.000 97.36085  ? 255 THR A N     1 ? 
ATOM   1998 C CA    . THR A 1 261 ? -14.77234 28.49500  27.71794  1.000 92.97579  ? 255 THR A CA    1 ? 
ATOM   1999 C C     . THR A 1 261 ? -15.79686 29.61241  27.54799  1.000 96.17517  ? 255 THR A C     1 ? 
ATOM   2000 O O     . THR A 1 261 ? -15.59671 30.53524  26.74970  1.000 93.20049  ? 255 THR A O     1 ? 
ATOM   2001 C CB    . THR A 1 261 ? -15.31078 27.17961  27.14989  1.000 90.42516  ? 255 THR A CB    1 ? 
ATOM   2002 O OG1   . THR A 1 261 ? -14.22222 26.29226  26.87031  1.000 84.26858  ? 255 THR A OG1   1 ? 
ATOM   2003 C CG2   . THR A 1 261 ? -16.07998 27.42213  25.86639  1.000 92.58283  ? 255 THR A CG2   1 ? 
ATOM   2004 N N     . MET A 1 262 ? -16.89738 29.55260  28.29526  1.000 99.00604  ? 256 MET A N     1 ? 
ATOM   2005 C CA    . MET A 1 262 ? -18.00737 30.47651  28.09422  1.000 98.74766  ? 256 MET A CA    1 ? 
ATOM   2006 C C     . MET A 1 262 ? -17.80635 31.82588  28.77292  1.000 99.04937  ? 256 MET A C     1 ? 
ATOM   2007 O O     . MET A 1 262 ? -18.68483 32.68796  28.66318  1.000 95.68395  ? 256 MET A O     1 ? 
ATOM   2008 C CB    . MET A 1 262 ? -19.30875 29.84082  28.59053  1.000 99.78896  ? 256 MET A CB    1 ? 
ATOM   2009 C CG    . MET A 1 262 ? -19.92718 28.81222  27.64266  1.000 90.02477  ? 256 MET A CG    1 ? 
ATOM   2010 S SD    . MET A 1 262 ? -19.36926 28.83360  25.92157  1.000 97.34456  ? 256 MET A SD    1 ? 
ATOM   2011 C CE    . MET A 1 262 ? -20.10253 30.35203  25.30880  1.000 92.92972  ? 256 MET A CE    1 ? 
ATOM   2012 N N     . SER A 1 263 ? -16.68908 32.03665  29.46479  1.000 100.74877 ? 257 SER A N     1 ? 
ATOM   2013 C CA    . SER A 1 263 ? -16.42241 33.31009  30.13470  1.000 101.19885 ? 257 SER A CA    1 ? 
ATOM   2014 C C     . SER A 1 263 ? -15.72543 34.30944  29.22406  1.000 95.35273  ? 257 SER A C     1 ? 
ATOM   2015 O O     . SER A 1 263 ? -14.82487 35.03170  29.66227  1.000 96.71531  ? 257 SER A O     1 ? 
ATOM   2016 C CB    . SER A 1 263 ? -15.60329 33.06697  31.39823  1.000 98.31492  ? 257 SER A CB    1 ? 
ATOM   2017 O OG    . SER A 1 263 ? -16.04190 31.90250  32.07410  1.000 102.50720 ? 257 SER A OG    1 ? 
ATOM   2018 N N     . VAL A 1 264 ? -16.12188 34.37756  27.95364  1.000 90.49739  ? 258 VAL A N     1 ? 
ATOM   2019 C CA    . VAL A 1 264 ? -15.47184 35.25870  26.99031  1.000 89.23958  ? 258 VAL A CA    1 ? 
ATOM   2020 C C     . VAL A 1 264 ? -16.38035 35.46097  25.78349  1.000 92.19766  ? 258 VAL A C     1 ? 
ATOM   2021 O O     . VAL A 1 264 ? -17.37215 34.74344  25.60998  1.000 94.51256  ? 258 VAL A O     1 ? 
ATOM   2022 C CB    . VAL A 1 264 ? -14.10301 34.69349  26.56796  1.000 88.56375  ? 258 VAL A CB    1 ? 
ATOM   2023 C CG1   . VAL A 1 264 ? -14.26544 33.70472  25.42089  1.000 89.46414  ? 258 VAL A CG1   1 ? 
ATOM   2024 C CG2   . VAL A 1 264 ? -13.14568 35.82130  26.20403  1.000 88.30376  ? 258 VAL A CG2   1 ? 
ATOM   2025 N N     . SER A 1 265 ? -16.04860 36.44072  24.94593  1.000 89.46442  ? 259 SER A N     1 ? 
ATOM   2026 C CA    . SER A 1 265 ? -16.83152 36.71980  23.75342  1.000 90.23077  ? 259 SER A CA    1 ? 
ATOM   2027 C C     . SER A 1 265 ? -16.65354 35.61292  22.71728  1.000 90.38698  ? 259 SER A C     1 ? 
ATOM   2028 O O     . SER A 1 265 ? -15.65865 34.88253  22.70823  1.000 90.43487  ? 259 SER A O     1 ? 
ATOM   2029 C CB    . SER A 1 265 ? -16.42699 38.06531  23.15134  1.000 96.86885  ? 259 SER A CB    1 ? 
ATOM   2030 O OG    . SER A 1 265 ? -15.01653 38.18250  23.07133  1.000 91.70905  ? 259 SER A OG    1 ? 
ATOM   2031 N N     . ALA A 1 266 ? -17.64398 35.49910  21.82844  1.000 88.45659  ? 260 ALA A N     1 ? 
ATOM   2032 C CA    . ALA A 1 266 ? -17.57416 34.49885  20.76885  1.000 81.26369  ? 260 ALA A CA    1 ? 
ATOM   2033 C C     . ALA A 1 266 ? -16.46180 34.80613  19.77594  1.000 89.46528  ? 260 ALA A C     1 ? 
ATOM   2034 O O     . ALA A 1 266 ? -15.90034 33.88448  19.17271  1.000 89.74461  ? 260 ALA A O     1 ? 
ATOM   2035 C CB    . ALA A 1 266 ? -18.91716 34.40177  20.04574  1.000 81.59386  ? 260 ALA A CB    1 ? 
ATOM   2036 N N     . GLU A 1 267 ? -16.13145 36.08635  19.59188  1.000 94.24502  ? 261 GLU A N     1 ? 
ATOM   2037 C CA    . GLU A 1 267 ? -15.06187 36.44699  18.66750  1.000 100.94927 ? 261 GLU A CA    1 ? 
ATOM   2038 C C     . GLU A 1 267 ? -13.70671 35.97822  19.18124  1.000 89.75801  ? 261 GLU A C     1 ? 
ATOM   2039 O O     . GLU A 1 267 ? -12.86245 35.52640  18.39858  1.000 90.54949  ? 261 GLU A O     1 ? 
ATOM   2040 C CB    . GLU A 1 267 ? -15.05664 37.95751  18.43625  1.000 102.13112 ? 261 GLU A CB    1 ? 
ATOM   2041 C CG    . GLU A 1 267 ? -16.15374 38.44573  17.50625  1.000 101.62932 ? 261 GLU A CG    1 ? 
ATOM   2042 C CD    . GLU A 1 267 ? -17.39933 38.88043  18.25305  1.000 111.00747 ? 261 GLU A CD    1 ? 
ATOM   2043 O OE1   . GLU A 1 267 ? -17.33680 39.89955  18.97233  1.000 116.07093 ? 261 GLU A OE1   1 ? 
ATOM   2044 O OE2   . GLU A 1 267 ? -18.44095 38.20365  18.12043  1.000 103.80289 ? 261 GLU A OE2   1 ? 
ATOM   2045 N N     . GLU A 1 268 ? -13.47892 36.07826  20.49239  1.000 90.80448  ? 262 GLU A N     1 ? 
ATOM   2046 C CA    . GLU A 1 268 ? -12.21925 35.61461  21.06051  1.000 95.81474  ? 262 GLU A CA    1 ? 
ATOM   2047 C C     . GLU A 1 268 ? -12.19386 34.10125  21.22678  1.000 91.65441  ? 262 GLU A C     1 ? 
ATOM   2048 O O     . GLU A 1 268 ? -11.13046 33.48674  21.08889  1.000 90.29850  ? 262 GLU A O     1 ? 
ATOM   2049 C CB    . GLU A 1 268 ? -11.96320 36.29540  22.40576  1.000 93.71898  ? 262 GLU A CB    1 ? 
ATOM   2050 C CG    . GLU A 1 268 ? -10.49958 36.32330  22.81310  1.000 104.70337 ? 262 GLU A CG    1 ? 
ATOM   2051 C CD    . GLU A 1 268 ? -10.13271 37.57558  23.58207  1.000 111.13503 ? 262 GLU A CD    1 ? 
ATOM   2052 O OE1   . GLU A 1 268 ? -10.93882 38.52960  23.58632  1.000 115.22465 ? 262 GLU A OE1   1 ? 
ATOM   2053 O OE2   . GLU A 1 268 ? -9.03815  37.60548  24.18263  1.000 112.19481 ? 262 GLU A OE2   1 ? 
ATOM   2054 N N     . ARG A 1 269 ? -13.34318 33.48986  21.52604  1.000 87.20689  ? 263 ARG A N     1 ? 
ATOM   2055 C CA    . ARG A 1 269 ? -13.41067 32.03457  21.60843  1.000 85.22461  ? 263 ARG A CA    1 ? 
ATOM   2056 C C     . ARG A 1 269 ? -13.01902 31.39299  20.28482  1.000 83.94647  ? 263 ARG A C     1 ? 
ATOM   2057 O O     . ARG A 1 269 ? -12.33937 30.36018  20.26241  1.000 81.01723  ? 263 ARG A O     1 ? 
ATOM   2058 C CB    . ARG A 1 269 ? -14.81654 31.60030  22.01795  1.000 84.79876  ? 263 ARG A CB    1 ? 
ATOM   2059 C CG    . ARG A 1 269 ? -14.87450 30.27255  22.74726  1.000 80.19470  ? 263 ARG A CG    1 ? 
ATOM   2060 C CD    . ARG A 1 269 ? -16.15779 30.12763  23.55167  1.000 85.30336  ? 263 ARG A CD    1 ? 
ATOM   2061 N NE    . ARG A 1 269 ? -17.34463 30.56662  22.82648  1.000 91.42606  ? 263 ARG A NE    1 ? 
ATOM   2062 C CZ    . ARG A 1 269 ? -17.95904 31.72551  23.02156  1.000 96.71988  ? 263 ARG A CZ    1 ? 
ATOM   2063 N NH1   . ARG A 1 269 ? -17.50692 32.60861  23.89667  1.000 93.11064  ? 263 ARG A NH1   1 ? 
ATOM   2064 N NH2   . ARG A 1 269 ? -19.05487 32.00410  22.32188  1.000 97.08474  ? 263 ARG A NH2   1 ? 
ATOM   2065 N N     . ASP A 1 270 ? -13.44465 31.99006  19.16920  1.000 86.03111  ? 264 ASP A N     1 ? 
ATOM   2066 C CA    . ASP A 1 270 ? -13.01868 31.50490  17.86226  1.000 85.54905  ? 264 ASP A CA    1 ? 
ATOM   2067 C C     . ASP A 1 270 ? -11.52859 31.72916  17.64512  1.000 87.61844  ? 264 ASP A C     1 ? 
ATOM   2068 O O     . ASP A 1 270 ? -10.87370 30.92701  16.96980  1.000 92.42372  ? 264 ASP A O     1 ? 
ATOM   2069 C CB    . ASP A 1 270 ? -13.82584 32.19088  16.76015  1.000 77.88790  ? 264 ASP A CB    1 ? 
ATOM   2070 C CG    . ASP A 1 270 ? -13.91350 31.35830  15.49685  1.000 94.30329  ? 264 ASP A CG    1 ? 
ATOM   2071 O OD1   . ASP A 1 270 ? -14.83392 30.51962  15.39882  1.000 98.48158  ? 264 ASP A OD1   1 ? 
ATOM   2072 O OD2   . ASP A 1 270 ? -13.06244 31.54278  14.60136  1.000 95.55045  ? 264 ASP A OD2   1 ? 
ATOM   2073 N N     . LYS A 1 271 ? -10.97780 32.80629  18.21028  1.000 82.58528  ? 265 LYS A N     1 ? 
ATOM   2074 C CA    . LYS A 1 271 ? -9.55008  33.07070  18.06702  1.000 86.05823  ? 265 LYS A CA    1 ? 
ATOM   2075 C C     . LYS A 1 271 ? -8.71872  32.05996  18.84776  1.000 79.33251  ? 265 LYS A C     1 ? 
ATOM   2076 O O     . LYS A 1 271 ? -7.66792  31.61404  18.37213  1.000 75.37093  ? 265 LYS A O     1 ? 
ATOM   2077 C CB    . LYS A 1 271 ? -9.23294  34.49531  18.52340  1.000 94.78578  ? 265 LYS A CB    1 ? 
ATOM   2078 C CG    . LYS A 1 271 ? -7.74723  34.82123  18.57041  1.000 108.47101 ? 265 LYS A CG    1 ? 
ATOM   2079 C CD    . LYS A 1 271 ? -7.39711  35.62783  19.81160  1.000 106.53968 ? 265 LYS A CD    1 ? 
ATOM   2080 C CE    . LYS A 1 271 ? -6.10351  36.40293  19.62228  1.000 112.91856 ? 265 LYS A CE    1 ? 
ATOM   2081 N NZ    . LYS A 1 271 ? -4.90731  35.52861  19.76937  1.000 113.04327 ? 265 LYS A NZ    1 ? 
ATOM   2082 N N     . ILE A 1 272 ? -9.17251  31.68397  20.04585  1.000 72.30582  ? 266 ILE A N     1 ? 
ATOM   2083 C CA    . ILE A 1 272 ? -8.41974  30.73063  20.85549  1.000 81.92816  ? 266 ILE A CA    1 ? 
ATOM   2084 C C     . ILE A 1 272 ? -8.43638  29.34935  20.21289  1.000 81.63343  ? 266 ILE A C     1 ? 
ATOM   2085 O O     . ILE A 1 272 ? -7.42401  28.63846  20.21258  1.000 80.31580  ? 266 ILE A O     1 ? 
ATOM   2086 C CB    . ILE A 1 272 ? -8.96727  30.69806  22.29425  1.000 84.23698  ? 266 ILE A CB    1 ? 
ATOM   2087 C CG1   . ILE A 1 272 ? -8.84888  32.08337  22.93746  1.000 82.31995  ? 266 ILE A CG1   1 ? 
ATOM   2088 C CG2   . ILE A 1 272 ? -8.24631  29.64071  23.12164  1.000 80.59442  ? 266 ILE A CG2   1 ? 
ATOM   2089 C CD1   . ILE A 1 272 ? -8.70052  32.05446  24.44606  1.000 85.19789  ? 266 ILE A CD1   1 ? 
ATOM   2090 N N     . PHE A 1 273 ? -9.57859  28.94762  19.65045  1.000 79.02258  ? 267 PHE A N     1 ? 
ATOM   2091 C CA    . PHE A 1 273 ? -9.64484  27.66204  18.96272  1.000 73.38158  ? 267 PHE A CA    1 ? 
ATOM   2092 C C     . PHE A 1 273 ? -8.78928  27.66408  17.70158  1.000 74.24905  ? 267 PHE A C     1 ? 
ATOM   2093 O O     . PHE A 1 273 ? -8.07251  26.69359  17.42931  1.000 77.13362  ? 267 PHE A O     1 ? 
ATOM   2094 C CB    . PHE A 1 273 ? -11.09379 27.31956  18.61800  1.000 70.84810  ? 267 PHE A CB    1 ? 
ATOM   2095 C CG    . PHE A 1 273 ? -11.88195 26.76435  19.76993  1.000 73.86821  ? 267 PHE A CG    1 ? 
ATOM   2096 C CD1   . PHE A 1 273 ? -11.34421 25.78593  20.58980  1.000 69.50160  ? 267 PHE A CD1   1 ? 
ATOM   2097 C CD2   . PHE A 1 273 ? -13.17161 27.20515  20.01813  1.000 68.65590  ? 267 PHE A CD2   1 ? 
ATOM   2098 C CE1   . PHE A 1 273 ? -12.07259 25.26750  21.64481  1.000 58.28554  ? 267 PHE A CE1   1 ? 
ATOM   2099 C CE2   . PHE A 1 273 ? -13.90532 26.69077  21.07089  1.000 69.74522  ? 267 PHE A CE2   1 ? 
ATOM   2100 C CZ    . PHE A 1 273 ? -13.35570 25.71888  21.88352  1.000 79.52062  ? 267 PHE A CZ    1 ? 
ATOM   2101 N N     . GLU A 1 274 ? -8.84924  28.74743  16.92189  1.000 71.77242  ? 268 GLU A N     1 ? 
ATOM   2102 C CA    . GLU A 1 274 ? -8.11241  28.80025  15.66316  1.000 75.01436  ? 268 GLU A CA    1 ? 
ATOM   2103 C C     . GLU A 1 274 ? -6.60536  28.80299  15.88657  1.000 76.45406  ? 268 GLU A C     1 ? 
ATOM   2104 O O     . GLU A 1 274 ? -5.85958  28.25860  15.06402  1.000 78.79832  ? 268 GLU A O     1 ? 
ATOM   2105 C CB    . GLU A 1 274 ? -8.53310  30.03155  14.85987  1.000 71.43313  ? 268 GLU A CB    1 ? 
ATOM   2106 C CG    . GLU A 1 274 ? -7.96447  30.08238  13.45041  1.000 77.79466  ? 268 GLU A CG    1 ? 
ATOM   2107 C CD    . GLU A 1 274 ? -8.79469  29.29366  12.45626  1.000 75.09520  ? 268 GLU A CD    1 ? 
ATOM   2108 O OE1   . GLU A 1 274 ? -9.94854  28.94815  12.78527  1.000 79.27608  ? 268 GLU A OE1   1 ? 
ATOM   2109 O OE2   . GLU A 1 274 ? -8.29380  29.02004  11.34501  1.000 74.08575  ? 268 GLU A OE2   1 ? 
ATOM   2110 N N     . LYS A 1 275 ? -6.13764  29.40690  16.98229  1.000 71.57794  ? 269 LYS A N     1 ? 
ATOM   2111 C CA    . LYS A 1 275 ? -4.70774  29.38698  17.27417  1.000 75.53179  ? 269 LYS A CA    1 ? 
ATOM   2112 C C     . LYS A 1 275 ? -4.23191  27.97417  17.58657  1.000 75.02398  ? 269 LYS A C     1 ? 
ATOM   2113 O O     . LYS A 1 275 ? -3.18351  27.54237  17.09259  1.000 66.73568  ? 269 LYS A O     1 ? 
ATOM   2114 C CB    . LYS A 1 275 ? -4.38930  30.33052  18.43376  1.000 84.84840  ? 269 LYS A CB    1 ? 
ATOM   2115 C CG    . LYS A 1 275 ? -2.92935  30.75520  18.49685  1.000 85.31328  ? 269 LYS A CG    1 ? 
ATOM   2116 C CD    . LYS A 1 275 ? -2.46130  30.93164  19.93200  1.000 91.24451  ? 269 LYS A CD    1 ? 
ATOM   2117 C CE    . LYS A 1 275 ? -0.95109  30.78794  20.04104  1.000 105.06897 ? 269 LYS A CE    1 ? 
ATOM   2118 N NZ    . LYS A 1 275 ? -0.55401  29.44139  20.53857  1.000 99.58287  ? 269 LYS A NZ    1 ? 
ATOM   2119 N N     . ALA A 1 276 ? -4.98839  27.23908  18.40545  1.000 72.56195  ? 270 ALA A N     1 ? 
ATOM   2120 C CA    . ALA A 1 276 ? -4.65703  25.84066  18.65168  1.000 71.80005  ? 270 ALA A CA    1 ? 
ATOM   2121 C C     . ALA A 1 276 ? -4.87389  24.99152  17.40726  1.000 73.55690  ? 270 ALA A C     1 ? 
ATOM   2122 O O     . ALA A 1 276 ? -4.15534  24.00802  17.19567  1.000 73.94583  ? 270 ALA A O     1 ? 
ATOM   2123 C CB    . ALA A 1 276 ? -5.48396  25.29875  19.81578  1.000 60.20560  ? 270 ALA A CB    1 ? 
ATOM   2124 N N     . TRP A 1 277 ? -5.85657  25.35236  16.57867  1.000 57.51911  ? 271 TRP A N     1 ? 
ATOM   2125 C CA    . TRP A 1 277 ? -6.06060  24.64667  15.31860  1.000 66.06628  ? 271 TRP A CA    1 ? 
ATOM   2126 C C     . TRP A 1 277 ? -4.85106  24.79353  14.40524  1.000 70.28061  ? 271 TRP A C     1 ? 
ATOM   2127 O O     . TRP A 1 277 ? -4.48449  23.85356  13.69038  1.000 73.21596  ? 271 TRP A O     1 ? 
ATOM   2128 C CB    . TRP A 1 277 ? -7.31979  25.16798  14.62597  1.000 71.77073  ? 271 TRP A CB    1 ? 
ATOM   2129 C CG    . TRP A 1 277 ? -7.66116  24.43962  13.36346  1.000 64.06606  ? 271 TRP A CG    1 ? 
ATOM   2130 C CD1   . TRP A 1 277 ? -7.24254  24.74651  12.10114  1.000 58.34178  ? 271 TRP A CD1   1 ? 
ATOM   2131 C CD2   . TRP A 1 277 ? -8.50216  23.28666  13.23804  1.000 65.43507  ? 271 TRP A CD2   1 ? 
ATOM   2132 N NE1   . TRP A 1 277 ? -7.76528  23.85224  11.19856  1.000 58.96342  ? 271 TRP A NE1   1 ? 
ATOM   2133 C CE2   . TRP A 1 277 ? -8.54383  22.94709  11.87091  1.000 60.65038  ? 271 TRP A CE2   1 ? 
ATOM   2134 C CE3   . TRP A 1 277 ? -9.22263  22.50767  14.14904  1.000 66.15452  ? 271 TRP A CE3   1 ? 
ATOM   2135 C CZ2   . TRP A 1 277 ? -9.27602  21.86206  11.39323  1.000 58.98435  ? 271 TRP A CZ2   1 ? 
ATOM   2136 C CZ3   . TRP A 1 277 ? -9.94920  21.43118  13.67299  1.000 55.25998  ? 271 TRP A CZ3   1 ? 
ATOM   2137 C CH2   . TRP A 1 277 ? -9.97026  21.11836  12.30782  1.000 69.61929  ? 271 TRP A CH2   1 ? 
ATOM   2138 N N     . GLN A 1 278 ? -4.21419  25.96580  14.41929  1.000 70.15375  ? 272 GLN A N     1 ? 
ATOM   2139 C CA    . GLN A 1 278 ? -3.07062  26.20267  13.54716  1.000 66.17508  ? 272 GLN A CA    1 ? 
ATOM   2140 C C     . GLN A 1 278 ? -1.78678  25.60124  14.10294  1.000 72.04835  ? 272 GLN A C     1 ? 
ATOM   2141 O O     . GLN A 1 278 ? -0.89624  25.23535  13.32768  1.000 71.66134  ? 272 GLN A O     1 ? 
ATOM   2142 C CB    . GLN A 1 278 ? -2.88999  27.70359  13.31351  1.000 69.77839  ? 272 GLN A CB    1 ? 
ATOM   2143 C CG    . GLN A 1 278 ? -3.91853  28.31232  12.37181  1.000 74.28431  ? 272 GLN A CG    1 ? 
ATOM   2144 C CD    . GLN A 1 278 ? -3.91720  27.66436  10.99919  1.000 82.97871  ? 272 GLN A CD    1 ? 
ATOM   2145 O OE1   . GLN A 1 278 ? -2.88812  27.17970  10.52702  1.000 87.10160  ? 272 GLN A OE1   1 ? 
ATOM   2146 N NE2   . GLN A 1 278 ? -5.07692  27.65063  10.35199  1.000 83.64825  ? 272 GLN A NE2   1 ? 
ATOM   2147 N N     . GLU A 1 279 ? -1.66799  25.49063  15.42782  1.000 71.44849  ? 273 GLU A N     1 ? 
ATOM   2148 C CA    . GLU A 1 279 ? -0.47138  24.89033  16.00744  1.000 76.30537  ? 273 GLU A CA    1 ? 
ATOM   2149 C C     . GLU A 1 279 ? -0.53856  23.36772  15.96798  1.000 71.75591  ? 273 GLU A C     1 ? 
ATOM   2150 O O     . GLU A 1 279 ? 0.48084   22.70439  15.74657  1.000 84.86608  ? 273 GLU A O     1 ? 
ATOM   2151 C CB    . GLU A 1 279 ? -0.27097  25.38780  17.44142  1.000 89.19042  ? 273 GLU A CB    1 ? 
ATOM   2152 C CG    . GLU A 1 279 ? 0.84820   24.68945  18.21997  1.000 91.70872  ? 273 GLU A CG    1 ? 
ATOM   2153 C CD    . GLU A 1 279 ? 2.25374   25.09908  17.79282  1.000 99.91634  ? 273 GLU A CD    1 ? 
ATOM   2154 O OE1   . GLU A 1 279 ? 2.47340   25.41800  16.60476  1.000 102.89670 ? 273 GLU A OE1   1 ? 
ATOM   2155 O OE2   . GLU A 1 279 ? 3.15161   25.09886  18.66103  1.000 97.36561  ? 273 GLU A OE2   1 ? 
ATOM   2156 N N     . GLY A 1 280 ? -1.72033  22.79995  16.17312  1.000 72.26959  ? 274 GLY A N     1 ? 
ATOM   2157 C CA    . GLY A 1 280 ? -1.91365  21.37321  16.03876  1.000 69.28259  ? 274 GLY A CA    1 ? 
ATOM   2158 C C     . GLY A 1 280 ? -1.86541  20.64860  17.37457  1.000 71.47795  ? 274 GLY A C     1 ? 
ATOM   2159 O O     . GLY A 1 280 ? -1.38959  21.16654  18.38779  1.000 73.20846  ? 274 GLY A O     1 ? 
ATOM   2160 N N     . GLY A 1 281 ? -2.37179  19.41746  17.36535  1.000 75.61566  ? 275 GLY A N     1 ? 
ATOM   2161 C CA    . GLY A 1 281 ? -2.37665  18.58886  18.55419  1.000 70.63245  ? 275 GLY A CA    1 ? 
ATOM   2162 C C     . GLY A 1 281 ? -3.75982  18.37368  19.13168  1.000 62.62615  ? 275 GLY A C     1 ? 
ATOM   2163 O O     . GLY A 1 281 ? -4.51140  19.33198  19.33435  1.000 71.17496  ? 275 GLY A O     1 ? 
ATOM   2164 N N     . GLY A 1 282 ? -4.10721  17.11419  19.40203  1.000 71.98124  ? 276 GLY A N     1 ? 
ATOM   2165 C CA    . GLY A 1 282 ? -5.41034  16.82628  19.97793  1.000 70.52825  ? 276 GLY A CA    1 ? 
ATOM   2166 C C     . GLY A 1 282 ? -5.54359  17.32581  21.40312  1.000 75.14746  ? 276 GLY A C     1 ? 
ATOM   2167 O O     . GLY A 1 282 ? -6.57764  17.88362  21.78111  1.000 76.68611  ? 276 GLY A O     1 ? 
ATOM   2168 N N     . PHE A 1 283 ? -4.50059  17.13635  22.21336  1.000 75.49491  ? 277 PHE A N     1 ? 
ATOM   2169 C CA    . PHE A 1 283 ? -4.54285  17.58961  23.59741  1.000 73.46555  ? 277 PHE A CA    1 ? 
ATOM   2170 C C     . PHE A 1 283 ? -4.45094  19.10515  23.71185  1.000 70.92310  ? 277 PHE A C     1 ? 
ATOM   2171 O O     . PHE A 1 283 ? -4.90343  19.66629  24.71547  1.000 72.08691  ? 277 PHE A O     1 ? 
ATOM   2172 C CB    . PHE A 1 283 ? -3.41872  16.93019  24.39795  1.000 78.44822  ? 277 PHE A CB    1 ? 
ATOM   2173 C CG    . PHE A 1 283 ? -3.62025  15.45814  24.62501  1.000 83.33352  ? 277 PHE A CG    1 ? 
ATOM   2174 C CD1   . PHE A 1 283 ? -3.27862  14.53891  23.64627  1.000 90.55395  ? 277 PHE A CD1   1 ? 
ATOM   2175 C CD2   . PHE A 1 283 ? -4.15153  14.99376  25.81649  1.000 82.98573  ? 277 PHE A CD2   1 ? 
ATOM   2176 C CE1   . PHE A 1 283 ? -3.46370  13.18488  23.85126  1.000 85.36729  ? 277 PHE A CE1   1 ? 
ATOM   2177 C CE2   . PHE A 1 283 ? -4.33876  13.64042  26.02772  1.000 81.95361  ? 277 PHE A CE2   1 ? 
ATOM   2178 C CZ    . PHE A 1 283 ? -3.99412  12.73522  25.04376  1.000 79.20037  ? 277 PHE A CZ    1 ? 
ATOM   2179 N N     . ARG A 1 284 ? -3.87843  19.77724  22.71081  1.000 68.68369  ? 278 ARG A N     1 ? 
ATOM   2180 C CA    . ARG A 1 284 ? -3.79434  21.23397  22.74527  1.000 73.04161  ? 278 ARG A CA    1 ? 
ATOM   2181 C C     . ARG A 1 284 ? -5.16637  21.86748  22.55694  1.000 74.94969  ? 278 ARG A C     1 ? 
ATOM   2182 O O     . ARG A 1 284 ? -5.56707  22.74819  23.32728  1.000 79.67406  ? 278 ARG A O     1 ? 
ATOM   2183 C CB    . ARG A 1 284 ? -2.82587  21.72855  21.67203  1.000 70.83207  ? 278 ARG A CB    1 ? 
ATOM   2184 C CG    . ARG A 1 284 ? -2.68779  23.23907  21.62147  1.000 68.96751  ? 278 ARG A CG    1 ? 
ATOM   2185 C CD    . ARG A 1 284 ? -1.69616  23.66810  20.55751  1.000 72.05651  ? 278 ARG A CD    1 ? 
ATOM   2186 N NE    . ARG A 1 284 ? -0.59095  22.72608  20.42968  1.000 78.98442  ? 278 ARG A NE    1 ? 
ATOM   2187 C CZ    . ARG A 1 284 ? 0.50868   22.75552  21.16984  1.000 79.68664  ? 278 ARG A CZ    1 ? 
ATOM   2188 N NH1   . ARG A 1 284 ? 0.68561   23.67029  22.10867  1.000 93.29674  ? 278 ARG A NH1   1 ? 
ATOM   2189 N NH2   . ARG A 1 284 ? 1.45533   21.84501  20.96167  1.000 81.38677  ? 278 ARG A NH2   1 ? 
ATOM   2190 N N     . PHE A 1 285 ? -5.89878  21.43111  21.52917  1.000 66.62890  ? 279 PHE A N     1 ? 
ATOM   2191 C CA    . PHE A 1 285 ? -7.23228  21.95872  21.26421  1.000 65.94093  ? 279 PHE A CA    1 ? 
ATOM   2192 C C     . PHE A 1 285 ? -8.18180  21.74524  22.43490  1.000 68.93037  ? 279 PHE A C     1 ? 
ATOM   2193 O O     . PHE A 1 285 ? -9.15543  22.49345  22.57518  1.000 70.82825  ? 279 PHE A O     1 ? 
ATOM   2194 C CB    . PHE A 1 285 ? -7.79890  21.30480  20.00119  1.000 64.81193  ? 279 PHE A CB    1 ? 
ATOM   2195 C CG    . PHE A 1 285 ? -9.05751  21.94639  19.48969  1.000 60.19914  ? 279 PHE A CG    1 ? 
ATOM   2196 C CD1   . PHE A 1 285 ? -8.99843  23.03620  18.63717  1.000 62.19375  ? 279 PHE A CD1   1 ? 
ATOM   2197 C CD2   . PHE A 1 285 ? -10.29989 21.44797  19.84734  1.000 52.85773  ? 279 PHE A CD2   1 ? 
ATOM   2198 C CE1   . PHE A 1 285 ? -10.15436 23.62309  18.16006  1.000 61.68049  ? 279 PHE A CE1   1 ? 
ATOM   2199 C CE2   . PHE A 1 285 ? -11.45928 22.03130  19.37448  1.000 66.24701  ? 279 PHE A CE2   1 ? 
ATOM   2200 C CZ    . PHE A 1 285 ? -11.38654 23.11875  18.52866  1.000 63.57176  ? 279 PHE A CZ    1 ? 
ATOM   2201 N N     . MET A 1 286 ? -7.91519  20.75350  23.28213  1.000 65.32110  ? 280 MET A N     1 ? 
ATOM   2202 C CA    . MET A 1 286 ? -8.80286  20.41389  24.38500  1.000 70.52196  ? 280 MET A CA    1 ? 
ATOM   2203 C C     . MET A 1 286 ? -8.35668  20.98300  25.72383  1.000 76.42664  ? 280 MET A C     1 ? 
ATOM   2204 O O     . MET A 1 286 ? -9.20204  21.21815  26.59345  1.000 87.24353  ? 280 MET A O     1 ? 
ATOM   2205 C CB    . MET A 1 286 ? -8.92729  18.89056  24.50662  1.000 76.33568  ? 280 MET A CB    1 ? 
ATOM   2206 C CG    . MET A 1 286 ? -10.03795 18.42699  25.43196  1.000 87.93329  ? 280 MET A CG    1 ? 
ATOM   2207 S SD    . MET A 1 286 ? -10.80358 16.88921  24.89132  1.000 121.64158 ? 280 MET A SD    1 ? 
ATOM   2208 C CE    . MET A 1 286 ? -11.79897 16.49627  26.32566  1.000 102.74458 ? 280 MET A CE    1 ? 
ATOM   2209 N N     . PHE A 1 287 ? -7.05919  21.21930  25.91658  1.000 75.92189  ? 281 PHE A N     1 ? 
ATOM   2210 C CA    . PHE A 1 287 ? -6.54950  21.60644  27.22651  1.000 72.34478  ? 281 PHE A CA    1 ? 
ATOM   2211 C C     . PHE A 1 287 ? -5.63312  22.82124  27.22510  1.000 72.10164  ? 281 PHE A C     1 ? 
ATOM   2212 O O     . PHE A 1 287 ? -5.44342  23.41638  28.29288  1.000 76.00756  ? 281 PHE A O     1 ? 
ATOM   2213 C CB    . PHE A 1 287 ? -5.81709  20.42463  27.87699  1.000 61.36416  ? 281 PHE A CB    1 ? 
ATOM   2214 C CG    . PHE A 1 287 ? -6.68719  19.21515  28.06610  1.000 70.02319  ? 281 PHE A CG    1 ? 
ATOM   2215 C CD1   . PHE A 1 287 ? -7.74576  19.24261  28.95893  1.000 73.01716  ? 281 PHE A CD1   1 ? 
ATOM   2216 C CD2   . PHE A 1 287 ? -6.46508  18.06112  27.33462  1.000 76.35308  ? 281 PHE A CD2   1 ? 
ATOM   2217 C CE1   . PHE A 1 287 ? -8.55515  18.13587  29.13168  1.000 76.98680  ? 281 PHE A CE1   1 ? 
ATOM   2218 C CE2   . PHE A 1 287 ? -7.27017  16.95097  27.50469  1.000 75.49273  ? 281 PHE A CE2   1 ? 
ATOM   2219 C CZ    . PHE A 1 287 ? -8.31709  16.98901  28.40259  1.000 72.83114  ? 281 PHE A CZ    1 ? 
ATOM   2220 N N     . GLU A 1 288 ? -5.05909  23.21197  26.08778  1.000 75.00035  ? 282 GLU A N     1 ? 
ATOM   2221 C CA    . GLU A 1 288 ? -4.33523  24.47555  26.02328  1.000 72.01040  ? 282 GLU A CA    1 ? 
ATOM   2222 C C     . GLU A 1 288 ? -5.25100  25.64697  25.70296  1.000 78.60000  ? 282 GLU A C     1 ? 
ATOM   2223 O O     . GLU A 1 288 ? -4.92954  26.78973  26.04970  1.000 83.01270  ? 282 GLU A O     1 ? 
ATOM   2224 C CB    . GLU A 1 288 ? -3.21372  24.40507  24.98302  1.000 71.82569  ? 282 GLU A CB    1 ? 
ATOM   2225 C CG    . GLU A 1 288 ? -1.91148  25.04054  25.44840  1.000 76.40356  ? 282 GLU A CG    1 ? 
ATOM   2226 C CD    . GLU A 1 288 ? -0.93429  25.28801  24.31577  1.000 80.02672  ? 282 GLU A CD    1 ? 
ATOM   2227 O OE1   . GLU A 1 288 ? -1.37766  25.70704  23.22626  1.000 81.86892  ? 282 GLU A OE1   1 ? 
ATOM   2228 O OE2   . GLU A 1 288 ? 0.27900   25.06667  24.51632  1.000 84.72317  ? 282 GLU A OE2   1 ? 
ATOM   2229 N N     . THR A 1 289 ? -6.38295  25.38623  25.04985  1.000 85.49378  ? 283 THR A N     1 ? 
ATOM   2230 C CA    . THR A 1 289 ? -7.37001  26.41994  24.76758  1.000 80.19916  ? 283 THR A CA    1 ? 
ATOM   2231 C C     . THR A 1 289 ? -8.01808  26.90112  26.05775  1.000 76.91429  ? 283 THR A C     1 ? 
ATOM   2232 O O     . THR A 1 289 ? -7.65126  27.95084  26.59578  1.000 84.85076  ? 283 THR A O     1 ? 
ATOM   2233 C CB    . THR A 1 289 ? -8.44367  25.89614  23.81089  1.000 77.33558  ? 283 THR A CB    1 ? 
ATOM   2234 O OG1   . THR A 1 289 ? -8.86753  24.59401  24.23391  1.000 71.04095  ? 283 THR A OG1   1 ? 
ATOM   2235 C CG2   . THR A 1 289 ? -7.90383  25.81041  22.39700  1.000 72.68571  ? 283 THR A CG2   1 ? 
ATOM   2236 N N     . PHE A 1 290 ? -8.98197  26.13541  26.55601  1.000 75.44526  ? 284 PHE A N     1 ? 
ATOM   2237 C CA    . PHE A 1 290 ? -9.69728  26.44411  27.78231  1.000 74.02958  ? 284 PHE A CA    1 ? 
ATOM   2238 C C     . PHE A 1 290 ? -9.55995  25.28127  28.75681  1.000 81.35118  ? 284 PHE A C     1 ? 
ATOM   2239 O O     . PHE A 1 290 ? -9.05281  24.20963  28.41572  1.000 83.78301  ? 284 PHE A O     1 ? 
ATOM   2240 C CB    . PHE A 1 290 ? -11.17249 26.74454  27.49223  1.000 78.95683  ? 284 PHE A CB    1 ? 
ATOM   2241 C CG    . PHE A 1 290 ? -11.38453 27.61886  26.28841  1.000 82.95919  ? 284 PHE A CG    1 ? 
ATOM   2242 C CD1   . PHE A 1 290 ? -11.17925 28.98645  26.36475  1.000 86.94636  ? 284 PHE A CD1   1 ? 
ATOM   2243 C CD2   . PHE A 1 290 ? -11.77733 27.07337  25.07798  1.000 82.69784  ? 284 PHE A CD2   1 ? 
ATOM   2244 C CE1   . PHE A 1 290 ? -11.36986 29.79400  25.25865  1.000 88.28160  ? 284 PHE A CE1   1 ? 
ATOM   2245 C CE2   . PHE A 1 290 ? -11.96821 27.87710  23.96998  1.000 85.18561  ? 284 PHE A CE2   1 ? 
ATOM   2246 C CZ    . PHE A 1 290 ? -11.76425 29.23737  24.06018  1.000 86.77658  ? 284 PHE A CZ    1 ? 
ATOM   2247 N N     . GLY A 1 291 ? -10.01933 25.50242  29.98569  1.000 83.02613  ? 285 GLY A N     1 ? 
ATOM   2248 C CA    . GLY A 1 291 ? -9.84119  24.51547  31.03195  1.000 80.16131  ? 285 GLY A CA    1 ? 
ATOM   2249 C C     . GLY A 1 291 ? -11.11564 23.85475  31.51433  1.000 85.75889  ? 285 GLY A C     1 ? 
ATOM   2250 O O     . GLY A 1 291 ? -11.13307 23.26200  32.59684  1.000 86.25745  ? 285 GLY A O     1 ? 
ATOM   2251 N N     . ASP A 1 292 ? -12.18981 23.93816  30.72562  1.000 83.62258  ? 286 ASP A N     1 ? 
ATOM   2252 C CA    . ASP A 1 292 ? -13.46452 23.34739  31.11338  1.000 80.94795  ? 286 ASP A CA    1 ? 
ATOM   2253 C C     . ASP A 1 292 ? -14.08522 22.49619  30.01233  1.000 80.51843  ? 286 ASP A C     1 ? 
ATOM   2254 O O     . ASP A 1 292 ? -15.24811 22.09598  30.14131  1.000 85.53899  ? 286 ASP A O     1 ? 
ATOM   2255 C CB    . ASP A 1 292 ? -14.45778 24.43453  31.53854  1.000 84.05782  ? 286 ASP A CB    1 ? 
ATOM   2256 C CG    . ASP A 1 292 ? -14.58321 25.53903  30.51196  1.000 89.09829  ? 286 ASP A CG    1 ? 
ATOM   2257 O OD1   . ASP A 1 292 ? -13.79582 25.54107  29.54249  1.000 93.97593  ? 286 ASP A OD1   1 ? 
ATOM   2258 O OD2   . ASP A 1 292 ? -15.47157 26.40228  30.67025  1.000 87.94004  ? 286 ASP A OD2   1 ? 
ATOM   2259 N N     . ILE A 1 293 ? -13.34608 22.20846  28.93817  1.000 79.60384  ? 287 ILE A N     1 ? 
ATOM   2260 C CA    . ILE A 1 293 ? -13.90171 21.43183  27.83337  1.000 81.30002  ? 287 ILE A CA    1 ? 
ATOM   2261 C C     . ILE A 1 293 ? -14.27107 20.02689  28.28908  1.000 89.52459  ? 287 ILE A C     1 ? 
ATOM   2262 O O     . ILE A 1 293 ? -15.26829 19.45580  27.82858  1.000 87.65049  ? 287 ILE A O     1 ? 
ATOM   2263 C CB    . ILE A 1 293 ? -12.90606 21.41069  26.65476  1.000 77.86762  ? 287 ILE A CB    1 ? 
ATOM   2264 C CG1   . ILE A 1 293 ? -12.87976 22.77429  25.96232  1.000 72.27850  ? 287 ILE A CG1   1 ? 
ATOM   2265 C CG2   . ILE A 1 293 ? -13.25686 20.31770  25.65563  1.000 84.04001  ? 287 ILE A CG2   1 ? 
ATOM   2266 C CD1   . ILE A 1 293 ? -11.52095 23.16504  25.43706  1.000 72.32729  ? 287 ILE A CD1   1 ? 
ATOM   2267 N N     . ALA A 1 294 ? -13.50344 19.45927  29.21499  1.000 86.47296  ? 288 ALA A N     1 ? 
ATOM   2268 C CA    . ALA A 1 294 ? -13.71733 18.09301  29.66671  1.000 86.47293  ? 288 ALA A CA    1 ? 
ATOM   2269 C C     . ALA A 1 294 ? -14.62396 17.99400  30.88923  1.000 90.37436  ? 288 ALA A C     1 ? 
ATOM   2270 O O     . ALA A 1 294 ? -14.78751 16.89525  31.42655  1.000 91.30180  ? 288 ALA A O     1 ? 
ATOM   2271 C CB    . ALA A 1 294 ? -12.37404 17.42167  29.96617  1.000 93.25042  ? 288 ALA A CB    1 ? 
ATOM   2272 N N     . VAL A 1 295 ? -15.23049 19.09620  31.33458  1.000 91.33721  ? 289 VAL A N     1 ? 
ATOM   2273 C CA    . VAL A 1 295 ? -16.08803 19.04373  32.51694  1.000 91.16000  ? 289 VAL A CA    1 ? 
ATOM   2274 C C     . VAL A 1 295 ? -17.43299 19.71738  32.26057  1.000 91.30489  ? 289 VAL A C     1 ? 
ATOM   2275 O O     . VAL A 1 295 ? -18.46723 19.25888  32.75869  1.000 96.95276  ? 289 VAL A O     1 ? 
ATOM   2276 C CB    . VAL A 1 295 ? -15.39063 19.66673  33.74180  1.000 83.58983  ? 289 VAL A CB    1 ? 
ATOM   2277 C CG1   . VAL A 1 295 ? -14.27730 18.75548  34.24017  1.000 85.48535  ? 289 VAL A CG1   1 ? 
ATOM   2278 C CG2   . VAL A 1 295 ? -14.84645 21.04102  33.40993  1.000 81.17151  ? 289 VAL A CG2   1 ? 
ATOM   2279 N N     . ASP A 1 296 ? -17.43833 20.79942  31.48579  1.000 92.06317  ? 290 ASP A N     1 ? 
ATOM   2280 C CA    . ASP A 1 296 ? -18.64314 21.58986  31.26126  1.000 92.07396  ? 290 ASP A CA    1 ? 
ATOM   2281 C C     . ASP A 1 296 ? -19.32134 21.16062  29.96642  1.000 92.86326  ? 290 ASP A C     1 ? 
ATOM   2282 O O     . ASP A 1 296 ? -18.66159 21.01690  28.93179  1.000 89.75038  ? 290 ASP A O     1 ? 
ATOM   2283 C CB    . ASP A 1 296 ? -18.31589 23.08345  31.21641  1.000 91.09200  ? 290 ASP A CB    1 ? 
ATOM   2284 C CG    . ASP A 1 296 ? -19.55977 23.95178  31.18782  1.000 92.24708  ? 290 ASP A CG    1 ? 
ATOM   2285 O OD1   . ASP A 1 296 ? -20.53695 23.61688  31.88957  1.000 96.29088  ? 290 ASP A OD1   1 ? 
ATOM   2286 O OD2   . ASP A 1 296 ? -19.55872 24.97109  30.46559  1.000 91.26619  ? 290 ASP A OD2   1 ? 
ATOM   2287 N N     . GLU A 1 297 ? -20.64174 20.96211  30.03014  1.000 92.57143  ? 291 GLU A N     1 ? 
ATOM   2288 C CA    . GLU A 1 297 ? -21.39288 20.55975  28.84420  1.000 94.17007  ? 291 GLU A CA    1 ? 
ATOM   2289 C C     . GLU A 1 297 ? -21.40917 21.66514  27.79592  1.000 90.48793  ? 291 GLU A C     1 ? 
ATOM   2290 O O     . GLU A 1 297 ? -21.28392 21.39222  26.59607  1.000 87.47705  ? 291 GLU A O     1 ? 
ATOM   2291 C CB    . GLU A 1 297 ? -22.82082 20.17159  29.23075  1.000 94.81105  ? 291 GLU A CB    1 ? 
ATOM   2292 C CG    . GLU A 1 297 ? -22.91465 18.98642  30.17713  1.000 102.45194 ? 291 GLU A CG    1 ? 
ATOM   2293 C CD    . GLU A 1 297 ? -23.43093 19.36826  31.54865  1.000 117.28641 ? 291 GLU A CD    1 ? 
ATOM   2294 O OE1   . GLU A 1 297 ? -22.61684 19.79288  32.39570  1.000 111.47967 ? 291 GLU A OE1   1 ? 
ATOM   2295 O OE2   . GLU A 1 297 ? -24.65101 19.23880  31.78124  1.000 118.03864 ? 291 GLU A OE2   1 ? 
ATOM   2296 N N     . THR A 1 298 ? -21.57249 22.91783  28.22797  1.000 86.89491  ? 292 THR A N     1 ? 
ATOM   2297 C CA    . THR A 1 298 ? -21.56129 24.03206  27.28582  1.000 87.92367  ? 292 THR A CA    1 ? 
ATOM   2298 C C     . THR A 1 298 ? -20.19027 24.19548  26.64328  1.000 86.12358  ? 292 THR A C     1 ? 
ATOM   2299 O O     . THR A 1 298 ? -20.08954 24.50284  25.44955  1.000 81.29505  ? 292 THR A O     1 ? 
ATOM   2300 C CB    . THR A 1 298 ? -21.97506 25.32289  27.99264  1.000 87.91502  ? 292 THR A CB    1 ? 
ATOM   2301 O OG1   . THR A 1 298 ? -22.82630 25.01103  29.10250  1.000 92.89549  ? 292 THR A OG1   1 ? 
ATOM   2302 C CG2   . THR A 1 298 ? -22.71519 26.24294  27.03372  1.000 74.15780  ? 292 THR A CG2   1 ? 
ATOM   2303 N N     . ALA A 1 299 ? -19.12438 23.98899  27.42007  1.000 88.99135  ? 293 ALA A N     1 ? 
ATOM   2304 C CA    . ALA A 1 299 ? -17.77505 24.13671  26.88636  1.000 88.08558  ? 293 ALA A CA    1 ? 
ATOM   2305 C C     . ALA A 1 299 ? -17.48467 23.09295  25.81641  1.000 82.88007  ? 293 ALA A C     1 ? 
ATOM   2306 O O     . ALA A 1 299 ? -16.88438 23.40444  24.78095  1.000 81.92745  ? 293 ALA A O     1 ? 
ATOM   2307 C CB    . ALA A 1 299 ? -16.75309 24.04143  28.01828  1.000 85.14689  ? 293 ALA A CB    1 ? 
ATOM   2308 N N     . ASN A 1 300 ? -17.90432 21.84689  26.04667  1.000 78.75810  ? 294 ASN A N     1 ? 
ATOM   2309 C CA    . ASN A 1 300 ? -17.62467 20.79042  25.08151  1.000 83.18847  ? 294 ASN A CA    1 ? 
ATOM   2310 C C     . ASN A 1 300 ? -18.43351 20.96609  23.80230  1.000 82.45297  ? 294 ASN A C     1 ? 
ATOM   2311 O O     . ASN A 1 300 ? -17.95877 20.60448  22.72000  1.000 80.57796  ? 294 ASN A O     1 ? 
ATOM   2312 C CB    . ASN A 1 300 ? -17.89740 19.42290  25.70520  1.000 72.23226  ? 294 ASN A CB    1 ? 
ATOM   2313 C CG    . ASN A 1 300 ? -17.35894 18.28369  24.86397  1.000 84.52590  ? 294 ASN A CG    1 ? 
ATOM   2314 O OD1   . ASN A 1 300 ? -17.99676 17.84768  23.90623  1.000 85.64258  ? 294 ASN A OD1   1 ? 
ATOM   2315 N ND2   . ASN A 1 300 ? -16.17501 17.79689  25.21694  1.000 89.42360  ? 294 ASN A ND2   1 ? 
ATOM   2316 N N     . ILE A 1 301 ? -19.64831 21.51267  23.90186  1.000 79.83896  ? 295 ILE A N     1 ? 
ATOM   2317 C CA    . ILE A 1 301 ? -20.42980 21.80683  22.70270  1.000 82.23264  ? 295 ILE A CA    1 ? 
ATOM   2318 C C     . ILE A 1 301 ? -19.71486 22.84272  21.84627  1.000 79.63686  ? 295 ILE A C     1 ? 
ATOM   2319 O O     . ILE A 1 301 ? -19.64364 22.71407  20.61728  1.000 80.68725  ? 295 ILE A O     1 ? 
ATOM   2320 C CB    . ILE A 1 301 ? -21.84865 22.27099  23.08571  1.000 84.78355  ? 295 ILE A CB    1 ? 
ATOM   2321 C CG1   . ILE A 1 301 ? -22.78930 21.07406  23.20795  1.000 71.96532  ? 295 ILE A CG1   1 ? 
ATOM   2322 C CG2   . ILE A 1 301 ? -22.39449 23.26102  22.06473  1.000 86.03904  ? 295 ILE A CG2   1 ? 
ATOM   2323 C CD1   . ILE A 1 301 ? -24.21127 21.44814  23.56808  1.000 76.39028  ? 295 ILE A CD1   1 ? 
ATOM   2324 N N     . GLU A 1 302 ? -19.16498 23.87998  22.48347  1.000 77.41906  ? 296 GLU A N     1 ? 
ATOM   2325 C CA    . GLU A 1 302 ? -18.49599 24.94271  21.74018  1.000 79.32803  ? 296 GLU A CA    1 ? 
ATOM   2326 C C     . GLU A 1 302 ? -17.29244 24.40975  20.97280  1.000 82.47391  ? 296 GLU A C     1 ? 
ATOM   2327 O O     . GLU A 1 302 ? -17.04324 24.81877  19.83255  1.000 73.72198  ? 296 GLU A O     1 ? 
ATOM   2328 C CB    . GLU A 1 302 ? -18.07413 26.05934  22.69548  1.000 82.12243  ? 296 GLU A CB    1 ? 
ATOM   2329 C CG    . GLU A 1 302 ? -18.43732 27.45660  22.22261  1.000 83.27702  ? 296 GLU A CG    1 ? 
ATOM   2330 C CD    . GLU A 1 302 ? -19.88990 27.57305  21.80170  1.000 89.64710  ? 296 GLU A CD    1 ? 
ATOM   2331 O OE1   . GLU A 1 302 ? -20.77144 27.12001  22.56279  1.000 83.26067  ? 296 GLU A OE1   1 ? 
ATOM   2332 O OE2   . GLU A 1 302 ? -20.15006 28.11926  20.70900  1.000 96.00545  ? 296 GLU A OE2   1 ? 
ATOM   2333 N N     . ALA A 1 303 ? -16.53620 23.49166  21.57958  1.000 79.08766  ? 297 ALA A N     1 ? 
ATOM   2334 C CA    . ALA A 1 303 ? -15.38174 22.91915  20.89505  1.000 76.33701  ? 297 ALA A CA    1 ? 
ATOM   2335 C C     . ALA A 1 303 ? -15.81199 22.01756  19.74455  1.000 78.38883  ? 297 ALA A C     1 ? 
ATOM   2336 O O     . ALA A 1 303 ? -15.14222 21.96564  18.70603  1.000 76.24112  ? 297 ALA A O     1 ? 
ATOM   2337 C CB    . ALA A 1 303 ? -14.51034 22.14960  21.88707  1.000 76.81744  ? 297 ALA A CB    1 ? 
ATOM   2338 N N     . GLN A 1 304 ? -16.92598 21.29932  19.91081  1.000 71.79604  ? 298 GLN A N     1 ? 
ATOM   2339 C CA    . GLN A 1 304 ? -17.42743 20.45129  18.83386  1.000 76.87360  ? 298 GLN A CA    1 ? 
ATOM   2340 C C     . GLN A 1 304 ? -17.83806 21.28052  17.62452  1.000 80.13989  ? 298 GLN A C     1 ? 
ATOM   2341 O O     . GLN A 1 304 ? -17.53332 20.91990  16.48139  1.000 75.71700  ? 298 GLN A O     1 ? 
ATOM   2342 C CB    . GLN A 1 304 ? -18.61065 19.61746  19.32530  1.000 74.52462  ? 298 GLN A CB    1 ? 
ATOM   2343 C CG    . GLN A 1 304 ? -18.25709 18.54178  20.33470  1.000 80.10486  ? 298 GLN A CG    1 ? 
ATOM   2344 C CD    . GLN A 1 304 ? -19.48864 17.89590  20.93916  1.000 89.50303  ? 298 GLN A CD    1 ? 
ATOM   2345 O OE1   . GLN A 1 304 ? -20.33016 17.34937  20.22590  1.000 91.37385  ? 298 GLN A OE1   1 ? 
ATOM   2346 N NE2   . GLN A 1 304 ? -19.60441 17.96240  22.25987  1.000 101.23254 ? 298 GLN A NE2   1 ? 
ATOM   2347 N N     . ASN A 1 305 ? -18.53028 22.39824  17.85802  1.000 74.60582  ? 299 ASN A N     1 ? 
ATOM   2348 C CA    . ASN A 1 305 ? -19.03674 23.20217  16.75150  1.000 73.86933  ? 299 ASN A CA    1 ? 
ATOM   2349 C C     . ASN A 1 305 ? -17.91111 23.86202  15.96593  1.000 78.81284  ? 299 ASN A C     1 ? 
ATOM   2350 O O     . ASN A 1 305 ? -18.07697 24.14603  14.77432  1.000 80.06005  ? 299 ASN A O     1 ? 
ATOM   2351 C CB    . ASN A 1 305 ? -20.01385 24.25432  17.27444  1.000 75.38830  ? 299 ASN A CB    1 ? 
ATOM   2352 C CG    . ASN A 1 305 ? -21.25405 23.63824  17.89236  1.000 78.51287  ? 299 ASN A CG    1 ? 
ATOM   2353 O OD1   . ASN A 1 305 ? -21.55152 22.46337  17.67435  1.000 75.92511  ? 299 ASN A OD1   1 ? 
ATOM   2354 N ND2   . ASN A 1 305 ? -21.98416 24.42922  18.66967  1.000 80.33644  ? 299 ASN A ND2   1 ? 
ATOM   2355 N N     . PHE A 1 306 ? -16.76658 24.11642  16.60509  1.000 72.77673  ? 300 PHE A N     1 ? 
ATOM   2356 C CA    . PHE A 1 306 ? -15.62938 24.65652  15.86740  1.000 71.83116  ? 300 PHE A CA    1 ? 
ATOM   2357 C C     . PHE A 1 306 ? -15.06757 23.62358  14.90020  1.000 72.52243  ? 300 PHE A C     1 ? 
ATOM   2358 O O     . PHE A 1 306 ? -14.73635 23.95217  13.75497  1.000 75.67825  ? 300 PHE A O     1 ? 
ATOM   2359 C CB    . PHE A 1 306 ? -14.54531 25.13584  16.83271  1.000 66.76102  ? 300 PHE A CB    1 ? 
ATOM   2360 C CG    . PHE A 1 306 ? -13.36713 25.77678  16.15025  1.000 70.06166  ? 300 PHE A CG    1 ? 
ATOM   2361 C CD1   . PHE A 1 306 ? -12.26506 25.02165  15.77944  1.000 69.71328  ? 300 PHE A CD1   1 ? 
ATOM   2362 C CD2   . PHE A 1 306 ? -13.36645 27.13362  15.87071  1.000 79.27379  ? 300 PHE A CD2   1 ? 
ATOM   2363 C CE1   . PHE A 1 306 ? -11.18313 25.60842  15.15011  1.000 73.13162  ? 300 PHE A CE1   1 ? 
ATOM   2364 C CE2   . PHE A 1 306 ? -12.28703 27.72634  15.24089  1.000 73.03326  ? 300 PHE A CE2   1 ? 
ATOM   2365 C CZ    . PHE A 1 306 ? -11.19454 26.96214  14.88055  1.000 72.81589  ? 300 PHE A CZ    1 ? 
ATOM   2366 N N     . ILE A 1 307 ? -14.94854 22.37079  15.34349  1.000 73.23119  ? 301 ILE A N     1 ? 
ATOM   2367 C CA    . ILE A 1 307 ? -14.51459 21.31042  14.44132  1.000 72.89958  ? 301 ILE A CA    1 ? 
ATOM   2368 C C     . ILE A 1 307 ? -15.58887 21.03449  13.39722  1.000 72.42641  ? 301 ILE A C     1 ? 
ATOM   2369 O O     . ILE A 1 307 ? -15.28573 20.82535  12.21663  1.000 72.18424  ? 301 ILE A O     1 ? 
ATOM   2370 C CB    . ILE A 1 307 ? -14.15152 20.04423  15.23804  1.000 63.83067  ? 301 ILE A CB    1 ? 
ATOM   2371 C CG1   . ILE A 1 307 ? -12.96708 20.32162  16.16507  1.000 69.81403  ? 301 ILE A CG1   1 ? 
ATOM   2372 C CG2   . ILE A 1 307 ? -13.81581 18.89984  14.29637  1.000 68.21232  ? 301 ILE A CG2   1 ? 
ATOM   2373 C CD1   . ILE A 1 307 ? -12.73296 19.24058  17.19724  1.000 77.61397  ? 301 ILE A CD1   1 ? 
ATOM   2374 N N     . LYS A 1 308 ? -16.85939 21.03970  13.81203  1.000 68.58030  ? 302 LYS A N     1 ? 
ATOM   2375 C CA    . LYS A 1 308 ? -17.95855 20.89203  12.86178  1.000 67.51852  ? 302 LYS A CA    1 ? 
ATOM   2376 C C     . LYS A 1 308 ? -17.90041 21.97067  11.78792  1.000 66.66232  ? 302 LYS A C     1 ? 
ATOM   2377 O O     . LYS A 1 308 ? -18.00971 21.67969  10.59103  1.000 72.19371  ? 302 LYS A O     1 ? 
ATOM   2378 C CB    . LYS A 1 308 ? -19.29893 20.94440  13.59585  1.000 70.83713  ? 302 LYS A CB    1 ? 
ATOM   2379 C CG    . LYS A 1 308 ? -19.66500 19.67799  14.34891  1.000 68.65058  ? 302 LYS A CG    1 ? 
ATOM   2380 C CD    . LYS A 1 308 ? -21.16384 19.62223  14.60369  1.000 71.22860  ? 302 LYS A CD    1 ? 
ATOM   2381 C CE    . LYS A 1 308 ? -21.47469 19.04543  15.97397  1.000 68.52669  ? 302 LYS A CE    1 ? 
ATOM   2382 N NZ    . LYS A 1 308 ? -20.88737 17.69026  16.14870  1.000 74.17903  ? 302 LYS A NZ    1 ? 
ATOM   2383 N N     . LYS A 1 309 ? -17.73288 23.22943  12.20237  1.000 71.41073  ? 303 LYS A N     1 ? 
ATOM   2384 C CA    . LYS A 1 309 ? -17.59080 24.31363  11.23672  1.000 74.84869  ? 303 LYS A CA    1 ? 
ATOM   2385 C C     . LYS A 1 309 ? -16.37566 24.09601  10.34680  1.000 74.64662  ? 303 LYS A C     1 ? 
ATOM   2386 O O     . LYS A 1 309 ? -16.43442 24.33161  9.13447   1.000 74.86787  ? 303 LYS A O     1 ? 
ATOM   2387 C CB    . LYS A 1 309 ? -17.48576 25.65465  11.96215  1.000 77.59618  ? 303 LYS A CB    1 ? 
ATOM   2388 C CG    . LYS A 1 309 ? -18.82037 26.30889  12.27270  1.000 79.66472  ? 303 LYS A CG    1 ? 
ATOM   2389 C CD    . LYS A 1 309 ? -18.61750 27.66737  12.92440  1.000 94.85030  ? 303 LYS A CD    1 ? 
ATOM   2390 C CE    . LYS A 1 309 ? -19.20266 27.70201  14.32690  1.000 98.72136  ? 303 LYS A CE    1 ? 
ATOM   2391 N NZ    . LYS A 1 309 ? -19.16395 29.07129  14.91119  1.000 92.56039  ? 303 LYS A NZ    1 ? 
ATOM   2392 N N     . LYS A 1 310 ? -15.26514 23.64173  10.93245  1.000 76.83490  ? 304 LYS A N     1 ? 
ATOM   2393 C CA    . LYS A 1 310 ? -14.06903 23.36489  10.14438  1.000 77.20247  ? 304 LYS A CA    1 ? 
ATOM   2394 C C     . LYS A 1 310 ? -14.33266 22.26814  9.12036   1.000 76.06780  ? 304 LYS A C     1 ? 
ATOM   2395 O O     . LYS A 1 310 ? -13.94394 22.38896  7.95400   1.000 71.41974  ? 304 LYS A O     1 ? 
ATOM   2396 C CB    . LYS A 1 310 ? -12.91039 22.98018  11.06565  1.000 74.26581  ? 304 LYS A CB    1 ? 
ATOM   2397 C CG    . LYS A 1 310 ? -12.19021 24.16677  11.68898  1.000 74.34048  ? 304 LYS A CG    1 ? 
ATOM   2398 C CD    . LYS A 1 310 ? -11.55818 25.05439  10.62794  1.000 75.93538  ? 304 LYS A CD    1 ? 
ATOM   2399 C CE    . LYS A 1 310 ? -10.46171 25.92600  11.21966  1.000 66.85823  ? 304 LYS A CE    1 ? 
ATOM   2400 N NZ    . LYS A 1 310 ? -9.65569  26.60219  10.16513  1.000 71.18149  ? 304 LYS A NZ    1 ? 
ATOM   2401 N N     . ILE A 1 311 ? -15.00543 21.19181  9.53941   1.000 74.23290  ? 305 ILE A N     1 ? 
ATOM   2402 C CA    . ILE A 1 311 ? -15.33424 20.10474  8.61868   1.000 71.66851  ? 305 ILE A CA    1 ? 
ATOM   2403 C C     . ILE A 1 311 ? -16.11987 20.63283  7.42454   1.000 70.12099  ? 305 ILE A C     1 ? 
ATOM   2404 O O     . ILE A 1 311 ? -15.88830 20.22435  6.27990   1.000 70.39318  ? 305 ILE A O     1 ? 
ATOM   2405 C CB    . ILE A 1 311 ? -16.10565 18.99362  9.35724   1.000 71.16533  ? 305 ILE A CB    1 ? 
ATOM   2406 C CG1   . ILE A 1 311 ? -15.20727 18.30780  10.38946  1.000 60.75626  ? 305 ILE A CG1   1 ? 
ATOM   2407 C CG2   . ILE A 1 311 ? -16.66198 17.97447  8.37211   1.000 55.91387  ? 305 ILE A CG2   1 ? 
ATOM   2408 C CD1   . ILE A 1 311 ? -15.80130 17.04328  10.97560  1.000 55.79546  ? 305 ILE A CD1   1 ? 
ATOM   2409 N N     . SER A 1 312 ? -17.04885 21.56100  7.66833   1.000 80.88412  ? 306 SER A N     1 ? 
ATOM   2410 C CA    . SER A 1 312 ? -17.85074 22.11091  6.58024   1.000 76.44837  ? 306 SER A CA    1 ? 
ATOM   2411 C C     . SER A 1 312 ? -17.00634 22.91627  5.60007   1.000 78.75307  ? 306 SER A C     1 ? 
ATOM   2412 O O     . SER A 1 312 ? -17.29988 22.92748  4.39948   1.000 79.75421  ? 306 SER A O     1 ? 
ATOM   2413 C CB    . SER A 1 312 ? -18.97624 22.97871  7.14475   1.000 73.89549  ? 306 SER A CB    1 ? 
ATOM   2414 O OG    . SER A 1 312 ? -19.73453 22.26972  8.11084   1.000 81.03522  ? 306 SER A OG    1 ? 
ATOM   2415 N N     . GLU A 1 313 ? -15.95839 23.58791  6.08383   1.000 77.27821  ? 307 GLU A N     1 ? 
ATOM   2416 C CA    . GLU A 1 313 ? -15.14904 24.42525  5.20320   1.000 77.03840  ? 307 GLU A CA    1 ? 
ATOM   2417 C C     . GLU A 1 313 ? -14.23927 23.58734  4.31268   1.000 79.94965  ? 307 GLU A C     1 ? 
ATOM   2418 O O     . GLU A 1 313 ? -13.99249 23.94873  3.15620   1.000 77.03215  ? 307 GLU A O     1 ? 
ATOM   2419 C CB    . GLU A 1 313 ? -14.32333 25.41328  6.02771   1.000 79.07070  ? 307 GLU A CB    1 ? 
ATOM   2420 C CG    . GLU A 1 313 ? -15.13452 26.25046  7.00103   1.000 82.72842  ? 307 GLU A CG    1 ? 
ATOM   2421 C CD    . GLU A 1 313 ? -14.29512 27.29817  7.70633   1.000 99.22282  ? 307 GLU A CD    1 ? 
ATOM   2422 O OE1   . GLU A 1 313 ? -13.69224 28.14520  7.01411   1.000 113.11489 ? 307 GLU A OE1   1 ? 
ATOM   2423 O OE2   . GLU A 1 313 ? -14.23645 27.27324  8.95373   1.000 104.89907 ? 307 GLU A OE2   1 ? 
ATOM   2424 N N     . ILE A 1 314 ? -13.72929 22.46935  4.82995   1.000 77.67495  ? 308 ILE A N     1 ? 
ATOM   2425 C CA    . ILE A 1 314 ? -12.77512 21.66574  4.07162   1.000 76.24119  ? 308 ILE A CA    1 ? 
ATOM   2426 C C     . ILE A 1 314 ? -13.49349 20.72047  3.11577   1.000 74.64915  ? 308 ILE A C     1 ? 
ATOM   2427 O O     . ILE A 1 314 ? -13.20788 20.69940  1.91322   1.000 70.79084  ? 308 ILE A O     1 ? 
ATOM   2428 C CB    . ILE A 1 314 ? -11.83771 20.90237  5.02559   1.000 77.00393  ? 308 ILE A CB    1 ? 
ATOM   2429 C CG1   . ILE A 1 314 ? -11.51997 21.74900  6.25844   1.000 69.89750  ? 308 ILE A CG1   1 ? 
ATOM   2430 C CG2   . ILE A 1 314 ? -10.56062 20.51613  4.31155   1.000 79.15826  ? 308 ILE A CG2   1 ? 
ATOM   2431 C CD1   . ILE A 1 314 ? -10.54942 21.09852  7.21853   1.000 55.11800  ? 308 ILE A CD1   1 ? 
ATOM   2432 N N     . VAL A 1 315 ? -14.42472 19.91983  3.62814   1.000 73.41215  ? 309 VAL A N     1 ? 
ATOM   2433 C CA    . VAL A 1 315 ? -15.16841 18.97788  2.79563   1.000 79.42130  ? 309 VAL A CA    1 ? 
ATOM   2434 C C     . VAL A 1 315 ? -16.16952 19.77237  1.96274   1.000 81.97838  ? 309 VAL A C     1 ? 
ATOM   2435 O O     . VAL A 1 315 ? -17.15278 20.29797  2.48989   1.000 81.08283  ? 309 VAL A O     1 ? 
ATOM   2436 C CB    . VAL A 1 315 ? -15.86898 17.90701  3.63866   1.000 76.24386  ? 309 VAL A CB    1 ? 
ATOM   2437 C CG1   . VAL A 1 315 ? -16.18553 16.68748  2.78621   1.000 78.61910  ? 309 VAL A CG1   1 ? 
ATOM   2438 C CG2   . VAL A 1 315 ? -15.00101 17.51575  4.82404   1.000 62.03255  ? 309 VAL A CG2   1 ? 
ATOM   2439 N N     . LYS A 1 316 ? -15.92218 19.85420  0.65255   1.000 82.50918  ? 310 LYS A N     1 ? 
ATOM   2440 C CA    . LYS A 1 316 ? -16.73238 20.71652  -0.20182  1.000 82.71406  ? 310 LYS A CA    1 ? 
ATOM   2441 C C     . LYS A 1 316 ? -18.11654 20.13300  -0.45546  1.000 80.88991  ? 310 LYS A C     1 ? 
ATOM   2442 O O     . LYS A 1 316 ? -19.08251 20.88737  -0.61616  1.000 98.50566  ? 310 LYS A O     1 ? 
ATOM   2443 C CB    . LYS A 1 316 ? -16.00903 20.97242  -1.52454  1.000 79.50488  ? 310 LYS A CB    1 ? 
ATOM   2444 C CG    . LYS A 1 316 ? -14.79807 21.89497  -1.41042  1.000 77.77836  ? 310 LYS A CG    1 ? 
ATOM   2445 C CD    . LYS A 1 316 ? -14.90994 22.83251  -0.21425  1.000 81.92152  ? 310 LYS A CD    1 ? 
ATOM   2446 C CE    . LYS A 1 316 ? -14.22509 24.16196  -0.47939  1.000 99.91178  ? 310 LYS A CE    1 ? 
ATOM   2447 N NZ    . LYS A 1 316 ? -14.93299 25.28802  0.19081   1.000 93.39701  ? 310 LYS A NZ    1 ? 
ATOM   2448 N N     . ASP A 1 317 ? -18.23572 18.80892  -0.50226  1.000 77.98193  ? 311 ASP A N     1 ? 
ATOM   2449 C CA    . ASP A 1 317 ? -19.53810 18.17480  -0.65682  1.000 84.57422  ? 311 ASP A CA    1 ? 
ATOM   2450 C C     . ASP A 1 317 ? -20.23338 18.14764  0.69874   1.000 84.33817  ? 311 ASP A C     1 ? 
ATOM   2451 O O     . ASP A 1 317 ? -19.76710 17.46823  1.62260   1.000 82.54318  ? 311 ASP A O     1 ? 
ATOM   2452 C CB    . ASP A 1 317 ? -19.39080 16.76156  -1.22701  1.000 85.42767  ? 311 ASP A CB    1 ? 
ATOM   2453 C CG    . ASP A 1 317 ? -20.72057 16.15089  -1.65164  1.000 89.62298  ? 311 ASP A CG    1 ? 
ATOM   2454 O OD1   . ASP A 1 317 ? -21.78521 16.63648  -1.21386  1.000 87.94646  ? 311 ASP A OD1   1 ? 
ATOM   2455 O OD2   . ASP A 1 317 ? -20.69832 15.17337  -2.42936  1.000 84.92133  ? 311 ASP A OD2   1 ? 
ATOM   2456 N N     . PRO A 1 318 ? -21.34366 18.87175  0.85877   1.000 82.92324  ? 312 PRO A N     1 ? 
ATOM   2457 C CA    . PRO A 1 318 ? -22.02874 18.88233  2.16121   1.000 79.92402  ? 312 PRO A CA    1 ? 
ATOM   2458 C C     . PRO A 1 318 ? -22.57721 17.52862  2.56785   1.000 76.73915  ? 312 PRO A C     1 ? 
ATOM   2459 O O     . PRO A 1 318 ? -22.74846 17.28351  3.76800   1.000 72.53052  ? 312 PRO A O     1 ? 
ATOM   2460 C CB    . PRO A 1 318 ? -23.15567 19.90431  1.95801   1.000 84.91950  ? 312 PRO A CB    1 ? 
ATOM   2461 C CG    . PRO A 1 318 ? -23.37386 19.93830  0.48029   1.000 85.77470  ? 312 PRO A CG    1 ? 
ATOM   2462 C CD    . PRO A 1 318 ? -22.02758 19.71397  -0.13648  1.000 74.31249  ? 312 PRO A CD    1 ? 
ATOM   2463 N N     . PHE A 1 319 ? -22.85755 16.64048  1.61183   1.000 77.16025  ? 313 PHE A N     1 ? 
ATOM   2464 C CA    . PHE A 1 319 ? -23.36029 15.31747  1.96510   1.000 77.73463  ? 313 PHE A CA    1 ? 
ATOM   2465 C C     . PHE A 1 319 ? -22.25470 14.44648  2.54827   1.000 78.39401  ? 313 PHE A C     1 ? 
ATOM   2466 O O     . PHE A 1 319 ? -22.49510 13.67206  3.48192   1.000 71.84896  ? 313 PHE A O     1 ? 
ATOM   2467 C CB    . PHE A 1 319 ? -23.99187 14.65194  0.74301   1.000 83.65813  ? 313 PHE A CB    1 ? 
ATOM   2468 C CG    . PHE A 1 319 ? -25.41613 15.06416  0.50029   1.000 94.71627  ? 313 PHE A CG    1 ? 
ATOM   2469 C CD1   . PHE A 1 319 ? -25.72231 16.36675  0.14092   1.000 92.86437  ? 313 PHE A CD1   1 ? 
ATOM   2470 C CD2   . PHE A 1 319 ? -26.44912 14.15203  0.63831   1.000 97.42019  ? 313 PHE A CD2   1 ? 
ATOM   2471 C CE1   . PHE A 1 319 ? -27.03102 16.75103  -0.08070  1.000 89.23743  ? 313 PHE A CE1   1 ? 
ATOM   2472 C CE2   . PHE A 1 319 ? -27.76046 14.53021  0.41810   1.000 112.01662 ? 313 PHE A CE2   1 ? 
ATOM   2473 C CZ    . PHE A 1 319 ? -28.05147 15.83151  0.05806   1.000 94.31495  ? 313 PHE A CZ    1 ? 
ATOM   2474 N N     . VAL A 1 320 ? -21.03669 14.55699  2.01210   1.000 78.09626  ? 314 VAL A N     1 ? 
ATOM   2475 C CA    . VAL A 1 320 ? -19.90767 13.85232  2.60994   1.000 72.93599  ? 314 VAL A CA    1 ? 
ATOM   2476 C C     . VAL A 1 320 ? -19.46498 14.54543  3.89054   1.000 73.86942  ? 314 VAL A C     1 ? 
ATOM   2477 O O     . VAL A 1 320 ? -19.00509 13.88894  4.83336   1.000 72.18857  ? 314 VAL A O     1 ? 
ATOM   2478 C CB    . VAL A 1 320 ? -18.74928 13.73174  1.60277   1.000 77.09906  ? 314 VAL A CB    1 ? 
ATOM   2479 C CG1   . VAL A 1 320 ? -17.81153 12.60763  2.00922   1.000 69.93579  ? 314 VAL A CG1   1 ? 
ATOM   2480 C CG2   . VAL A 1 320 ? -19.28962 13.48425  0.20535   1.000 65.77217  ? 314 VAL A CG2   1 ? 
ATOM   2481 N N     . ALA A 1 321 ? -19.59259 15.87368  3.95064   1.000 73.91627  ? 315 ALA A N     1 ? 
ATOM   2482 C CA    . ALA A 1 321 ? -19.27929 16.59178  5.18155   1.000 72.38420  ? 315 ALA A CA    1 ? 
ATOM   2483 C C     . ALA A 1 321 ? -20.24881 16.22010  6.29575   1.000 74.45184  ? 315 ALA A C     1 ? 
ATOM   2484 O O     . ALA A 1 321 ? -19.85264 16.11809  7.46270   1.000 68.65265  ? 315 ALA A O     1 ? 
ATOM   2485 C CB    . ALA A 1 321 ? -19.29964 18.09926  4.93186   1.000 72.07185  ? 315 ALA A CB    1 ? 
ATOM   2486 N N     . LYS A 1 322 ? -21.52447 16.01735  5.95543   1.000 73.75978  ? 316 LYS A N     1 ? 
ATOM   2487 C CA    . LYS A 1 322 ? -22.49194 15.56419  6.94913   1.000 64.22706  ? 316 LYS A CA    1 ? 
ATOM   2488 C C     . LYS A 1 322 ? -22.16069 14.15907  7.43341   1.000 70.80390  ? 316 LYS A C     1 ? 
ATOM   2489 O O     . LYS A 1 322 ? -22.37309 13.83314  8.60718   1.000 71.09785  ? 316 LYS A O     1 ? 
ATOM   2490 C CB    . LYS A 1 322 ? -23.90482 15.60830  6.36663   1.000 66.85691  ? 316 LYS A CB    1 ? 
ATOM   2491 C CG    . LYS A 1 322 ? -24.55591 16.98181  6.39284   1.000 77.48306  ? 316 LYS A CG    1 ? 
ATOM   2492 C CD    . LYS A 1 322 ? -25.67501 17.07373  5.36588   1.000 90.97714  ? 316 LYS A CD    1 ? 
ATOM   2493 C CE    . LYS A 1 322 ? -26.05105 18.51823  5.07835   1.000 81.76857  ? 316 LYS A CE    1 ? 
ATOM   2494 N NZ    . LYS A 1 322 ? -26.77495 18.65312  3.78356   1.000 83.51031  ? 316 LYS A NZ    1 ? 
ATOM   2495 N N     . LYS A 1 323 ? -21.63751 13.31422  6.54174   1.000 77.66405  ? 317 LYS A N     1 ? 
ATOM   2496 C CA    . LYS A 1 323 ? -21.28024 11.95354  6.92583   1.000 72.74896  ? 317 LYS A CA    1 ? 
ATOM   2497 C C     . LYS A 1 323 ? -20.06982 11.92928  7.85073   1.000 71.38429  ? 317 LYS A C     1 ? 
ATOM   2498 O O     . LYS A 1 323 ? -19.98569 11.07089  8.73646   1.000 74.00231  ? 317 LYS A O     1 ? 
ATOM   2499 C CB    . LYS A 1 323 ? -21.01287 11.11359  5.67640   1.000 71.92333  ? 317 LYS A CB    1 ? 
ATOM   2500 C CG    . LYS A 1 323 ? -21.46356 9.66660   5.78363   1.000 80.34469  ? 317 LYS A CG    1 ? 
ATOM   2501 C CD    . LYS A 1 323 ? -21.18183 8.90783   4.49646   1.000 77.97152  ? 317 LYS A CD    1 ? 
ATOM   2502 C CE    . LYS A 1 323 ? -22.15326 9.30350   3.39598   1.000 81.66228  ? 317 LYS A CE    1 ? 
ATOM   2503 N NZ    . LYS A 1 323 ? -22.14618 8.32708   2.27126   1.000 78.94463  ? 317 LYS A NZ    1 ? 
ATOM   2504 N N     . LEU A 1 324 ? -19.12990 12.85733  7.66590   1.000 69.85949  ? 318 LEU A N     1 ? 
ATOM   2505 C CA    . LEU A 1 324 ? -17.93196 12.91576  8.49375   1.000 69.18810  ? 318 LEU A CA    1 ? 
ATOM   2506 C C     . LEU A 1 324 ? -18.16809 13.57722  9.84439   1.000 70.26010  ? 318 LEU A C     1 ? 
ATOM   2507 O O     . LEU A 1 324 ? -17.28651 13.51251  10.70800  1.000 82.50858  ? 318 LEU A O     1 ? 
ATOM   2508 C CB    . LEU A 1 324 ? -16.81886 13.66492  7.75690   1.000 57.05202  ? 318 LEU A CB    1 ? 
ATOM   2509 C CG    . LEU A 1 324 ? -16.14968 12.93128  6.59629   1.000 51.29228  ? 318 LEU A CG    1 ? 
ATOM   2510 C CD1   . LEU A 1 324 ? -15.50229 13.91699  5.63689   1.000 54.12966  ? 318 LEU A CD1   1 ? 
ATOM   2511 C CD2   . LEU A 1 324 ? -15.13042 11.93300  7.11978   1.000 62.35588  ? 318 LEU A CD2   1 ? 
ATOM   2512 N N     . THR A 1 325 ? -19.31660 14.20459  10.04712  1.000 63.89428  ? 319 THR A N     1 ? 
ATOM   2513 C CA    . THR A 1 325 ? -19.56524 14.92870  11.28729  1.000 68.75446  ? 319 THR A CA    1 ? 
ATOM   2514 C C     . THR A 1 325 ? -20.01920 13.96253  12.37649  1.000 70.76150  ? 319 THR A C     1 ? 
ATOM   2515 O O     . THR A 1 325 ? -20.94913 13.18080  12.15415  1.000 77.09662  ? 319 THR A O     1 ? 
ATOM   2516 C CB    . THR A 1 325 ? -20.61983 16.00984  11.07427  1.000 68.37765  ? 319 THR A CB    1 ? 
ATOM   2517 O OG1   . THR A 1 325 ? -20.18347 16.90675  10.04512  1.000 71.24182  ? 319 THR A OG1   1 ? 
ATOM   2518 C CG2   . THR A 1 325 ? -20.84370 16.79282  12.35632  1.000 65.10691  ? 319 THR A CG2   1 ? 
ATOM   2519 N N     . PRO A 1 326 ? -19.39007 13.97997  13.54960  1.000 75.71474  ? 320 PRO A N     1 ? 
ATOM   2520 C CA    . PRO A 1 326 ? -19.82485 13.09052  14.63148  1.000 80.28392  ? 320 PRO A CA    1 ? 
ATOM   2521 C C     . PRO A 1 326 ? -21.21697 13.44986  15.12479  1.000 82.12351  ? 320 PRO A C     1 ? 
ATOM   2522 O O     . PRO A 1 326 ? -21.66421 14.59519  15.02589  1.000 79.26469  ? 320 PRO A O     1 ? 
ATOM   2523 C CB    . PRO A 1 326 ? -18.77253 13.31569  15.72510  1.000 72.72271  ? 320 PRO A CB    1 ? 
ATOM   2524 C CG    . PRO A 1 326 ? -17.60018 13.92584  15.01779  1.000 71.92606  ? 320 PRO A CG    1 ? 
ATOM   2525 C CD    . PRO A 1 326 ? -18.18303 14.74078  13.90880  1.000 68.20544  ? 320 PRO A CD    1 ? 
ATOM   2526 N N     . THR A 1 327 ? -21.90387 12.44495  15.66562  1.000 85.34278  ? 321 THR A N     1 ? 
ATOM   2527 C CA    . THR A 1 327 ? -23.27461 12.59683  16.13180  1.000 88.38068  ? 321 THR A CA    1 ? 
ATOM   2528 C C     . THR A 1 327 ? -23.40307 12.53796  17.64702  1.000 88.27628  ? 321 THR A C     1 ? 
ATOM   2529 O O     . THR A 1 327 ? -24.52227 12.62869  18.16302  1.000 92.88567  ? 321 THR A O     1 ? 
ATOM   2530 C CB    . THR A 1 327 ? -24.16904 11.52239  15.50189  1.000 88.22126  ? 321 THR A CB    1 ? 
ATOM   2531 O OG1   . THR A 1 327 ? -23.79433 10.23267  16.00222  1.000 86.04647  ? 321 THR A OG1   1 ? 
ATOM   2532 C CG2   . THR A 1 327 ? -24.02742 11.53422  13.98698  1.000 70.26224  ? 321 THR A CG2   1 ? 
ATOM   2533 N N     . ASP A 1 328 ? -22.29859 12.38864  18.37166  1.000 93.47540  ? 322 ASP A N     1 ? 
ATOM   2534 C CA    . ASP A 1 328 ? -22.36478 12.32639  19.82315  1.000 100.78972 ? 322 ASP A CA    1 ? 
ATOM   2535 C C     . ASP A 1 328 ? -22.73011 13.68652  20.40663  1.000 97.59385  ? 322 ASP A C     1 ? 
ATOM   2536 O O     . ASP A 1 328 ? -22.39640 14.73842  19.85412  1.000 93.91286  ? 322 ASP A O     1 ? 
ATOM   2537 C CB    . ASP A 1 328 ? -21.03056 11.85339  20.40208  1.000 108.56268 ? 322 ASP A CB    1 ? 
ATOM   2538 C CG    . ASP A 1 328 ? -19.85377 12.67334  19.90506  1.000 100.26095 ? 322 ASP A CG    1 ? 
ATOM   2539 O OD1   . ASP A 1 328 ? -19.67506 13.81551  20.37942  1.000 94.11409  ? 322 ASP A OD1   1 ? 
ATOM   2540 O OD2   . ASP A 1 328 ? -19.10287 12.17224  19.04219  1.000 91.36851  ? 322 ASP A OD2   1 ? 
ATOM   2541 N N     . LEU A 1 329 ? -23.43506 13.65358  21.53816  1.000 98.66599  ? 323 LEU A N     1 ? 
ATOM   2542 C CA    . LEU A 1 329 ? -23.73756 14.87957  22.26572  1.000 100.05451 ? 323 LEU A CA    1 ? 
ATOM   2543 C C     . LEU A 1 329 ? -22.52925 15.37803  23.04812  1.000 102.59038 ? 323 LEU A C     1 ? 
ATOM   2544 O O     . LEU A 1 329 ? -22.34348 16.59198  23.19068  1.000 95.82036  ? 323 LEU A O     1 ? 
ATOM   2545 C CB    . LEU A 1 329 ? -24.92618 14.64693  23.20155  1.000 97.23239  ? 323 LEU A CB    1 ? 
ATOM   2546 C CG    . LEU A 1 329 ? -25.30024 15.73753  24.20627  1.000 93.28618  ? 323 LEU A CG    1 ? 
ATOM   2547 C CD1   . LEU A 1 329 ? -25.79209 16.98354  23.48858  1.000 95.78477  ? 323 LEU A CD1   1 ? 
ATOM   2548 C CD2   . LEU A 1 329 ? -26.35456 15.22179  25.17266  1.000 91.60040  ? 323 LEU A CD2   1 ? 
ATOM   2549 N N     . TYR A 1 330 ? -21.70076 14.46292  23.54594  1.000 114.47886 ? 324 TYR A N     1 ? 
ATOM   2550 C CA    . TYR A 1 330 ? -20.48270 14.78795  24.27294  1.000 102.34416 ? 324 TYR A CA    1 ? 
ATOM   2551 C C     . TYR A 1 330 ? -19.29586 14.12435  23.58851  1.000 97.10564  ? 324 TYR A C     1 ? 
ATOM   2552 O O     . TYR A 1 330 ? -19.40823 13.00319  23.08322  1.000 98.08226  ? 324 TYR A O     1 ? 
ATOM   2553 C CB    . TYR A 1 330 ? -20.57397 14.32984  25.73133  1.000 107.15058 ? 324 TYR A CB    1 ? 
ATOM   2554 C CG    . TYR A 1 330 ? -21.76494 14.88960  26.47585  1.000 112.75893 ? 324 TYR A CG    1 ? 
ATOM   2555 C CD1   . TYR A 1 330 ? -21.87931 16.25127  26.71533  1.000 107.95746 ? 324 TYR A CD1   1 ? 
ATOM   2556 C CD2   . TYR A 1 330 ? -22.77320 14.05661  26.94209  1.000 111.33426 ? 324 TYR A CD2   1 ? 
ATOM   2557 C CE1   . TYR A 1 330 ? -22.96421 16.76895  27.39741  1.000 104.34235 ? 324 TYR A CE1   1 ? 
ATOM   2558 C CE2   . TYR A 1 330 ? -23.86274 14.56677  27.62509  1.000 110.32709 ? 324 TYR A CE2   1 ? 
ATOM   2559 C CZ    . TYR A 1 330 ? -23.95307 15.92427  27.84776  1.000 109.20898 ? 324 TYR A CZ    1 ? 
ATOM   2560 O OH    . TYR A 1 330 ? -25.03332 16.44085  28.52573  1.000 110.35897 ? 324 TYR A OH    1 ? 
ATOM   2561 N N     . ALA A 1 331 ? -18.15723 14.81497  23.57719  1.000 98.21889  ? 325 ALA A N     1 ? 
ATOM   2562 C CA    . ALA A 1 331 ? -16.97232 14.35059  22.86736  1.000 99.72150  ? 325 ALA A CA    1 ? 
ATOM   2563 C C     . ALA A 1 331 ? -15.77031 14.34826  23.79911  1.000 96.99060  ? 325 ALA A C     1 ? 
ATOM   2564 O O     . ALA A 1 331 ? -15.50455 15.34520  24.47818  1.000 95.86685  ? 325 ALA A O     1 ? 
ATOM   2565 C CB    . ALA A 1 331 ? -16.68516 15.22798  21.64574  1.000 93.69241  ? 325 ALA A CB    1 ? 
ATOM   2566 N N     . CYS A 1 332 ? -15.04194 13.23130  23.82061  1.000 100.48232 ? 326 CYS A N     1 ? 
ATOM   2567 C CA    . CYS A 1 332 ? -13.80710 13.13479  24.58994  1.000 105.41562 ? 326 CYS A CA    1 ? 
ATOM   2568 C C     . CYS A 1 332 ? -12.63672 13.71025  23.80290  1.000 106.65310 ? 326 CYS A C     1 ? 
ATOM   2569 O O     . CYS A 1 332 ? -12.77334 14.74225  23.13793  1.000 106.35146 ? 326 CYS A O     1 ? 
ATOM   2570 C CB    . CYS A 1 332 ? -13.51646 11.68145  24.97394  1.000 101.96958 ? 326 CYS A CB    1 ? 
ATOM   2571 S SG    . CYS A 1 332 ? -14.50798 11.03818  26.33811  1.000 117.27598 ? 326 CYS A SG    1 ? 
ATOM   2572 N N     . ARG A 1 333 ? -11.48959 13.04691  23.86827  1.000 110.13837 ? 327 ARG A N     1 ? 
ATOM   2573 C CA    . ARG A 1 333 ? -10.30482 13.53265  23.17211  1.000 106.37719 ? 327 ARG A CA    1 ? 
ATOM   2574 C C     . ARG A 1 333 ? -10.43705 13.28184  21.67377  1.000 106.52521 ? 327 ARG A C     1 ? 
ATOM   2575 O O     . ARG A 1 333 ? -10.79496 12.17062  21.26499  1.000 101.87709 ? 327 ARG A O     1 ? 
ATOM   2576 C CB    . ARG A 1 333 ? -9.05091  12.84788  23.71266  1.000 101.54566 ? 327 ARG A CB    1 ? 
ATOM   2577 C CG    . ARG A 1 333 ? -7.76351  13.26292  23.01562  1.000 91.88798  ? 327 ARG A CG    1 ? 
ATOM   2578 C CD    . ARG A 1 333 ? -6.97039  12.06382  22.51139  1.000 98.17012  ? 327 ARG A CD    1 ? 
ATOM   2579 N NE    . ARG A 1 333 ? -7.74147  11.22775  21.59817  1.000 111.33024 ? 327 ARG A NE    1 ? 
ATOM   2580 C CZ    . ARG A 1 333 ? -8.31375  10.07927  21.93264  1.000 114.93890 ? 327 ARG A CZ    1 ? 
ATOM   2581 N NH1   . ARG A 1 333 ? -8.22055  9.59260   23.15907  1.000 118.10309 ? 327 ARG A NH1   1 ? 
ATOM   2582 N NH2   . ARG A 1 333 ? -8.99625  9.40228   21.01325  1.000 101.13159 ? 327 ARG A NH2   1 ? 
ATOM   2583 N N     . PRO A 1 334 ? -10.16838 14.27375  20.83182  1.000 95.21867  ? 328 PRO A N     1 ? 
ATOM   2584 C CA    . PRO A 1 334 ? -10.20328 14.05389  19.38408  1.000 93.08085  ? 328 PRO A CA    1 ? 
ATOM   2585 C C     . PRO A 1 334 ? -8.90445  13.42837  18.88976  1.000 95.84853  ? 328 PRO A C     1 ? 
ATOM   2586 O O     . PRO A 1 334 ? -7.94017  13.24509  19.63345  1.000 92.25942  ? 328 PRO A O     1 ? 
ATOM   2587 C CB    . PRO A 1 334 ? -10.38957 15.46380  18.81601  1.000 77.42284  ? 328 PRO A CB    1 ? 
ATOM   2588 C CG    . PRO A 1 334 ? -9.78117  16.36329  19.83898  1.000 83.43264  ? 328 PRO A CG    1 ? 
ATOM   2589 C CD    . PRO A 1 334 ? -9.89364  15.67924  21.17926  1.000 90.07140  ? 328 PRO A CD    1 ? 
ATOM   2590 N N     . LEU A 1 335 ? -8.89848  13.10056  17.60253  1.000 83.78252  ? 329 LEU A N     1 ? 
ATOM   2591 C CA    . LEU A 1 335 ? -7.72287  12.53789  16.95958  1.000 77.11012  ? 329 LEU A CA    1 ? 
ATOM   2592 C C     . LEU A 1 335 ? -6.88779  13.64143  16.31415  1.000 74.04740  ? 329 LEU A C     1 ? 
ATOM   2593 O O     . LEU A 1 335 ? -7.31415  14.79085  16.18780  1.000 76.31729  ? 329 LEU A O     1 ? 
ATOM   2594 C CB    . LEU A 1 335 ? -8.12813  11.49816  15.91359  1.000 70.58924  ? 329 LEU A CB    1 ? 
ATOM   2595 C CG    . LEU A 1 335 ? -9.24030  10.51888  16.29270  1.000 70.89485  ? 329 LEU A CG    1 ? 
ATOM   2596 C CD1   . LEU A 1 335 ? -9.65946  9.69496   15.08472  1.000 61.52649  ? 329 LEU A CD1   1 ? 
ATOM   2597 C CD2   . LEU A 1 335 ? -8.79528  9.61482   17.43086  1.000 65.19228  ? 329 LEU A CD2   1 ? 
ATOM   2598 N N     . CYS A 1 336 ? -5.67582  13.27646  15.90644  1.000 72.53651  ? 330 CYS A N     1 ? 
ATOM   2599 C CA    . CYS A 1 336 ? -4.78815  14.16440  15.17065  1.000 76.52178  ? 330 CYS A CA    1 ? 
ATOM   2600 C C     . CYS A 1 336 ? -4.54223  13.58644  13.78521  1.000 65.51162  ? 330 CYS A C     1 ? 
ATOM   2601 O O     . CYS A 1 336 ? -4.45495  12.36564  13.61905  1.000 62.94070  ? 330 CYS A O     1 ? 
ATOM   2602 C CB    . CYS A 1 336 ? -3.45978  14.36510  15.90723  1.000 69.39424  ? 330 CYS A CB    1 ? 
ATOM   2603 S SG    . CYS A 1 336 ? -3.61658  14.45797  17.70384  1.000 89.30593  ? 330 CYS A SG    1 ? 
ATOM   2604 N N     . ASP A 1 337 ? -4.43226  14.46477  12.79133  1.000 58.05129  ? 331 ASP A N     1 ? 
ATOM   2605 C CA    . ASP A 1 337 ? -4.32120  14.01865  11.41175  1.000 65.90581  ? 331 ASP A CA    1 ? 
ATOM   2606 C C     . ASP A 1 337 ? -3.45249  14.98574  10.62282  1.000 69.40195  ? 331 ASP A C     1 ? 
ATOM   2607 O O     . ASP A 1 337 ? -3.21656  16.12435  11.03555  1.000 64.33071  ? 331 ASP A O     1 ? 
ATOM   2608 C CB    . ASP A 1 337 ? -5.70128  13.88537  10.75914  1.000 65.40492  ? 331 ASP A CB    1 ? 
ATOM   2609 C CG    . ASP A 1 337 ? -6.31197  15.22604  10.39962  1.000 71.58948  ? 331 ASP A CG    1 ? 
ATOM   2610 O OD1   . ASP A 1 337 ? -6.99160  15.82096  11.26266  1.000 70.75111  ? 331 ASP A OD1   1 ? 
ATOM   2611 O OD2   . ASP A 1 337 ? -6.12145  15.68004  9.25104   1.000 70.32345  ? 331 ASP A OD2   1 ? 
ATOM   2612 N N     . SER A 1 338 ? -2.97976  14.50926  9.47141   1.000 69.42657  ? 332 SER A N     1 ? 
ATOM   2613 C CA    . SER A 1 338 ? -2.17141  15.31980  8.57025   1.000 69.74375  ? 332 SER A CA    1 ? 
ATOM   2614 C C     . SER A 1 338 ? -2.88005  15.48952  7.23228   1.000 71.17321  ? 332 SER A C     1 ? 
ATOM   2615 O O     . SER A 1 338 ? -2.31624  15.17511  6.17897   1.000 72.64662  ? 332 SER A O     1 ? 
ATOM   2616 C CB    . SER A 1 338 ? -0.79251  14.68718  8.36941   1.000 72.72079  ? 332 SER A CB    1 ? 
ATOM   2617 O OG    . SER A 1 338 ? -0.04473  14.69515  9.57272   1.000 69.95634  ? 332 SER A OG    1 ? 
ATOM   2618 N N     . GLY A 1 339 ? -4.11640  15.98202  7.26584   1.000 63.86847  ? 333 GLY A N     1 ? 
ATOM   2619 C CA    . GLY A 1 339 ? -4.89278  16.17404  6.05681   1.000 66.83425  ? 333 GLY A CA    1 ? 
ATOM   2620 C C     . GLY A 1 339 ? -5.91107  15.07630  5.83028   1.000 69.97829  ? 333 GLY A C     1 ? 
ATOM   2621 O O     . GLY A 1 339 ? -6.00542  14.52607  4.72956   1.000 68.76742  ? 333 GLY A O     1 ? 
ATOM   2622 N N     . TYR A 1 340 ? -6.68678  14.75403  6.86738   1.000 73.96725  ? 334 TYR A N     1 ? 
ATOM   2623 C CA    . TYR A 1 340 ? -7.63816  13.65098  6.77826   1.000 67.29766  ? 334 TYR A CA    1 ? 
ATOM   2624 C C     . TYR A 1 340 ? -8.93576  14.08200  6.10759   1.000 66.71914  ? 334 TYR A C     1 ? 
ATOM   2625 O O     . TYR A 1 340 ? -9.39470  13.43861  5.15753   1.000 75.96902  ? 334 TYR A O     1 ? 
ATOM   2626 C CB    . TYR A 1 340 ? -7.91229  13.08553  8.17227   1.000 56.29444  ? 334 TYR A CB    1 ? 
ATOM   2627 C CG    . TYR A 1 340 ? -9.09515  12.15006  8.24349   1.000 65.35587  ? 334 TYR A CG    1 ? 
ATOM   2628 C CD1   . TYR A 1 340 ? -9.04336  10.88828  7.66621   1.000 64.00857  ? 334 TYR A CD1   1 ? 
ATOM   2629 C CD2   . TYR A 1 340 ? -10.26062 12.52436  8.89797   1.000 65.97851  ? 334 TYR A CD2   1 ? 
ATOM   2630 C CE1   . TYR A 1 340 ? -10.12295 10.02821  7.73181   1.000 61.15362  ? 334 TYR A CE1   1 ? 
ATOM   2631 C CE2   . TYR A 1 340 ? -11.34473 11.67188  8.96933   1.000 64.17447  ? 334 TYR A CE2   1 ? 
ATOM   2632 C CZ    . TYR A 1 340 ? -11.27090 10.42523  8.38511   1.000 63.71253  ? 334 TYR A CZ    1 ? 
ATOM   2633 O OH    . TYR A 1 340 ? -12.34956 9.57347   8.45433   1.000 66.08805  ? 334 TYR A OH    1 ? 
ATOM   2634 N N     . TYR A 1 341 ? -9.54584  15.16385  6.59415   1.000 70.27400  ? 335 TYR A N     1 ? 
ATOM   2635 C CA    . TYR A 1 341 ? -10.76371 15.66595  5.97240   1.000 70.30354  ? 335 TYR A CA    1 ? 
ATOM   2636 C C     . TYR A 1 341 ? -10.50974 16.19377  4.56681   1.000 61.68894  ? 335 TYR A C     1 ? 
ATOM   2637 O O     . TYR A 1 341 ? -11.44008 16.23407  3.75466   1.000 72.72513  ? 335 TYR A O     1 ? 
ATOM   2638 C CB    . TYR A 1 341 ? -11.38397 16.75495  6.84890   1.000 74.04453  ? 335 TYR A CB    1 ? 
ATOM   2639 C CG    . TYR A 1 341 ? -11.84045 16.25302  8.20109   1.000 70.07781  ? 335 TYR A CG    1 ? 
ATOM   2640 C CD1   . TYR A 1 341 ? -12.68303 15.15406  8.30713   1.000 63.92034  ? 335 TYR A CD1   1 ? 
ATOM   2641 C CD2   . TYR A 1 341 ? -11.42128 16.87213  9.37138   1.000 59.48824  ? 335 TYR A CD2   1 ? 
ATOM   2642 C CE1   . TYR A 1 341 ? -13.10035 14.68953  9.54217   1.000 62.26631  ? 335 TYR A CE1   1 ? 
ATOM   2643 C CE2   . TYR A 1 341 ? -11.83252 16.41566  10.60971  1.000 62.80159  ? 335 TYR A CE2   1 ? 
ATOM   2644 C CZ    . TYR A 1 341 ? -12.67153 15.32448  10.68919  1.000 64.55038  ? 335 TYR A CZ    1 ? 
ATOM   2645 O OH    . TYR A 1 341 ? -13.08256 14.86812  11.91997  1.000 66.11191  ? 335 TYR A OH    1 ? 
ATOM   2646 N N     . GLU A 1 342 ? -9.27182  16.59347  4.26369   1.000 52.56622  ? 336 GLU A N     1 ? 
ATOM   2647 C CA    . GLU A 1 342 ? -8.91653  16.99078  2.90704   1.000 69.12099  ? 336 GLU A CA    1 ? 
ATOM   2648 C C     . GLU A 1 342 ? -8.93392  15.81588  1.93944   1.000 75.15402  ? 336 GLU A C     1 ? 
ATOM   2649 O O     . GLU A 1 342 ? -9.06552  16.02656  0.72915   1.000 69.11818  ? 336 GLU A O     1 ? 
ATOM   2650 C CB    . GLU A 1 342 ? -7.52993  17.63865  2.89308   1.000 70.11184  ? 336 GLU A CB    1 ? 
ATOM   2651 C CG    . GLU A 1 342 ? -7.48628  19.05834  3.42805   1.000 80.86335  ? 336 GLU A CG    1 ? 
ATOM   2652 C CD    . GLU A 1 342 ? -6.97871  19.12932  4.85495   1.000 87.79924  ? 336 GLU A CD    1 ? 
ATOM   2653 O OE1   . GLU A 1 342 ? -7.43910  18.32257  5.69010   1.000 79.70803  ? 336 GLU A OE1   1 ? 
ATOM   2654 O OE2   . GLU A 1 342 ? -6.12161  19.99220  5.14194   1.000 89.27754  ? 336 GLU A OE2   1 ? 
ATOM   2655 N N     . ILE A 1 343 ? -8.80488  14.58833  2.44730   1.000 64.81008  ? 337 ILE A N     1 ? 
ATOM   2656 C CA    . ILE A 1 343 ? -8.69683  13.41983  1.58112   1.000 66.87576  ? 337 ILE A CA    1 ? 
ATOM   2657 C C     . ILE A 1 343 ? -10.01041 13.14836  0.85739   1.000 68.47896  ? 337 ILE A C     1 ? 
ATOM   2658 O O     . ILE A 1 343 ? -10.01166 12.70871  -0.29958  1.000 53.76943  ? 337 ILE A O     1 ? 
ATOM   2659 C CB    . ILE A 1 343 ? -8.23398  12.20606  2.41198   1.000 62.48667  ? 337 ILE A CB    1 ? 
ATOM   2660 C CG1   . ILE A 1 343 ? -6.71332  12.23047  2.58281   1.000 67.17231  ? 337 ILE A CG1   1 ? 
ATOM   2661 C CG2   . ILE A 1 343 ? -8.70142  10.89231  1.79424   1.000 53.47802  ? 337 ILE A CG2   1 ? 
ATOM   2662 C CD1   . ILE A 1 343 ? -5.94975  12.17241  1.28104   1.000 75.21328  ? 337 ILE A CD1   1 ? 
ATOM   2663 N N     . PHE A 1 344 ? -11.14135 13.42514  1.50131   1.000 61.33313  ? 338 PHE A N     1 ? 
ATOM   2664 C CA    . PHE A 1 344 ? -12.44219 13.06858  0.95029   1.000 61.39359  ? 338 PHE A CA    1 ? 
ATOM   2665 C C     . PHE A 1 344 ? -12.91907 14.01672  -0.14336  1.000 67.94080  ? 338 PHE A C     1 ? 
ATOM   2666 O O     . PHE A 1 344 ? -14.02843 13.83204  -0.65461  1.000 70.99370  ? 338 PHE A O     1 ? 
ATOM   2667 C CB    . PHE A 1 344 ? -13.47362 12.99876  2.07728   1.000 60.79733  ? 338 PHE A CB    1 ? 
ATOM   2668 C CG    . PHE A 1 344 ? -13.15672 11.95846  3.11116   1.000 55.51517  ? 338 PHE A CG    1 ? 
ATOM   2669 C CD1   . PHE A 1 344 ? -13.47488 10.62766  2.89433   1.000 56.31805  ? 338 PHE A CD1   1 ? 
ATOM   2670 C CD2   . PHE A 1 344 ? -12.51568 12.30621  4.28780   1.000 59.82343  ? 338 PHE A CD2   1 ? 
ATOM   2671 C CE1   . PHE A 1 344 ? -13.17552 9.66539   3.84070   1.000 57.62499  ? 338 PHE A CE1   1 ? 
ATOM   2672 C CE2   . PHE A 1 344 ? -12.21175 11.34935  5.23672   1.000 60.41266  ? 338 PHE A CE2   1 ? 
ATOM   2673 C CZ    . PHE A 1 344 ? -12.54297 10.02717  5.01365   1.000 56.55648  ? 338 PHE A CZ    1 ? 
ATOM   2674 N N     . ASN A 1 345 ? -12.12114 15.01438  -0.51623  1.000 69.41213  ? 339 ASN A N     1 ? 
ATOM   2675 C CA    . ASN A 1 345 ? -12.42817 15.87780  -1.64925  1.000 67.90084  ? 339 ASN A CA    1 ? 
ATOM   2676 C C     . ASN A 1 345 ? -11.93641 15.30815  -2.97270  1.000 71.45196  ? 339 ASN A C     1 ? 
ATOM   2677 O O     . ASN A 1 345 ? -12.16327 15.92403  -4.01966  1.000 80.43739  ? 339 ASN A O     1 ? 
ATOM   2678 C CB    . ASN A 1 345 ? -11.81611 17.26803  -1.44239  1.000 67.65057  ? 339 ASN A CB    1 ? 
ATOM   2679 C CG    . ASN A 1 345 ? -12.57308 18.09603  -0.42448  1.000 72.22524  ? 339 ASN A CG    1 ? 
ATOM   2680 O OD1   . ASN A 1 345 ? -13.78783 17.96442  -0.27828  1.000 73.36726  ? 339 ASN A OD1   1 ? 
ATOM   2681 N ND2   . ASN A 1 345 ? -11.85617 18.96187  0.28313   1.000 67.58124  ? 339 ASN A ND2   1 ? 
ATOM   2682 N N     . ARG A 1 346 ? -11.27844 14.15491  -2.95145  1.000 63.18560  ? 340 ARG A N     1 ? 
ATOM   2683 C CA    . ARG A 1 346 ? -10.63210 13.59904  -4.12897  1.000 70.39080  ? 340 ARG A CA    1 ? 
ATOM   2684 C C     . ARG A 1 346 ? -11.61416 12.78602  -4.96667  1.000 73.27294  ? 340 ARG A C     1 ? 
ATOM   2685 O O     . ARG A 1 346 ? -12.64498 12.31130  -4.48296  1.000 71.17415  ? 340 ARG A O     1 ? 
ATOM   2686 C CB    . ARG A 1 346 ? -9.44674  12.72554  -3.71913  1.000 68.21808  ? 340 ARG A CB    1 ? 
ATOM   2687 C CG    . ARG A 1 346 ? -8.38501  13.46702  -2.92569  1.000 70.90488  ? 340 ARG A CG    1 ? 
ATOM   2688 C CD    . ARG A 1 346 ? -7.32968  12.51359  -2.39604  1.000 68.60204  ? 340 ARG A CD    1 ? 
ATOM   2689 N NE    . ARG A 1 346 ? -6.88422  11.57775  -3.42061  1.000 72.12682  ? 340 ARG A NE    1 ? 
ATOM   2690 C CZ    . ARG A 1 346 ? -5.69357  11.61809  -4.00224  1.000 74.92637  ? 340 ARG A CZ    1 ? 
ATOM   2691 N NH1   . ARG A 1 346 ? -4.79706  12.53593  -3.67863  1.000 83.74433  ? 340 ARG A NH1   1 ? 
ATOM   2692 N NH2   . ARG A 1 346 ? -5.39549  10.71646  -4.93320  1.000 71.60797  ? 340 ARG A NH2   1 ? 
ATOM   2693 N N     . ASP A 1 347 ? -11.26972 12.62885  -6.24727  1.000 71.89468  ? 341 ASP A N     1 ? 
ATOM   2694 C CA    . ASP A 1 347 ? -12.09548 11.85371  -7.16376  1.000 73.23668  ? 341 ASP A CA    1 ? 
ATOM   2695 C C     . ASP A 1 347 ? -12.06650 10.36396  -6.85244  1.000 77.07860  ? 341 ASP A C     1 ? 
ATOM   2696 O O     . ASP A 1 347 ? -13.00572 9.64928   -7.21739  1.000 80.68276  ? 341 ASP A O     1 ? 
ATOM   2697 C CB    . ASP A 1 347 ? -11.63264 12.07744  -8.60633  1.000 86.34239  ? 341 ASP A CB    1 ? 
ATOM   2698 C CG    . ASP A 1 347 ? -11.49536 13.54476  -8.95776  1.000 107.63474 ? 341 ASP A CG    1 ? 
ATOM   2699 O OD1   . ASP A 1 347 ? -12.05399 14.38938  -8.22838  1.000 110.06912 ? 341 ASP A OD1   1 ? 
ATOM   2700 O OD2   . ASP A 1 347 ? -10.82429 13.85419  -9.96425  1.000 109.87181 ? 341 ASP A OD2   1 ? 
ATOM   2701 N N     . ASN A 1 348 ? -11.01537 9.88184   -6.18898  1.000 64.50309  ? 342 ASN A N     1 ? 
ATOM   2702 C CA    . ASN A 1 348 ? -10.79272 8.45499   -5.99618  1.000 59.79534  ? 342 ASN A CA    1 ? 
ATOM   2703 C C     . ASN A 1 348 ? -11.04893 8.00409   -4.56171  1.000 58.55940  ? 342 ASN A C     1 ? 
ATOM   2704 O O     . ASN A 1 348 ? -10.56061 6.94558   -4.15382  1.000 64.44044  ? 342 ASN A O     1 ? 
ATOM   2705 C CB    . ASN A 1 348 ? -9.36892  8.09096   -6.41608  1.000 65.24815  ? 342 ASN A CB    1 ? 
ATOM   2706 C CG    . ASN A 1 348 ? -8.31995  8.68863   -5.49743  1.000 74.35934  ? 342 ASN A CG    1 ? 
ATOM   2707 O OD1   . ASN A 1 348 ? -8.50490  9.77535   -4.94951  1.000 76.09525  ? 342 ASN A OD1   1 ? 
ATOM   2708 N ND2   . ASN A 1 348 ? -7.21038  7.97921   -5.32458  1.000 64.71448  ? 342 ASN A ND2   1 ? 
ATOM   2709 N N     . VAL A 1 349 ? -11.80183 8.78004   -3.78702  1.000 58.55176  ? 343 VAL A N     1 ? 
ATOM   2710 C CA    . VAL A 1 349 ? -12.10118 8.45512   -2.39753  1.000 56.03167  ? 343 VAL A CA    1 ? 
ATOM   2711 C C     . VAL A 1 349 ? -13.61252 8.40675   -2.22740  1.000 65.00280  ? 343 VAL A C     1 ? 
ATOM   2712 O O     . VAL A 1 349 ? -14.31889 9.33550   -2.63677  1.000 65.15752  ? 343 VAL A O     1 ? 
ATOM   2713 C CB    . VAL A 1 349 ? -11.47336 9.47080   -1.42543  1.000 56.53966  ? 343 VAL A CB    1 ? 
ATOM   2714 C CG1   . VAL A 1 349 ? -11.71650 9.04483   0.01451   1.000 47.22329  ? 343 VAL A CG1   1 ? 
ATOM   2715 C CG2   . VAL A 1 349 ? -9.98405  9.61585   -1.69758  1.000 59.94824  ? 343 VAL A CG2   1 ? 
ATOM   2716 N N     . SER A 1 350 ? -14.10375 7.32661   -1.62330  1.000 62.75810  ? 344 SER A N     1 ? 
ATOM   2717 C CA    . SER A 1 350 ? -15.52566 7.14402   -1.36664  1.000 56.49992  ? 344 SER A CA    1 ? 
ATOM   2718 C C     . SER A 1 350 ? -15.73046 6.85509   0.11168   1.000 57.17991  ? 344 SER A C     1 ? 
ATOM   2719 O O     . SER A 1 350 ? -15.07534 5.96969   0.67068   1.000 63.45357  ? 344 SER A O     1 ? 
ATOM   2720 C CB    . SER A 1 350 ? -16.10390 6.00366   -2.21244  1.000 55.24366  ? 344 SER A CB    1 ? 
ATOM   2721 O OG    . SER A 1 350 ? -15.74455 6.14376   -3.57552  1.000 63.52655  ? 344 SER A OG    1 ? 
ATOM   2722 N N     . LEU A 1 351 ? -16.63271 7.60185   0.74004   1.000 61.11851  ? 345 LEU A N     1 ? 
ATOM   2723 C CA    . LEU A 1 351 ? -16.98209 7.39823   2.13876   1.000 61.51737  ? 345 LEU A CA    1 ? 
ATOM   2724 C C     . LEU A 1 351 ? -18.25929 6.57453   2.22391   1.000 70.69033  ? 345 LEU A C     1 ? 
ATOM   2725 O O     . LEU A 1 351 ? -19.24417 6.87474   1.54094   1.000 77.99375  ? 345 LEU A O     1 ? 
ATOM   2726 C CB    . LEU A 1 351 ? -17.16451 8.73350   2.86039   1.000 52.68421  ? 345 LEU A CB    1 ? 
ATOM   2727 C CG    . LEU A 1 351 ? -17.36607 8.63085   4.37270   1.000 64.17066  ? 345 LEU A CG    1 ? 
ATOM   2728 C CD1   . LEU A 1 351 ? -16.20645 7.89010   5.02350   1.000 65.47911  ? 345 LEU A CD1   1 ? 
ATOM   2729 C CD2   . LEU A 1 351 ? -17.54227 10.00797  4.98444   1.000 60.16130  ? 345 LEU A CD2   1 ? 
ATOM   2730 N N     . GLU A 1 352 ? -18.23966 5.54063   3.06141   1.000 73.11959  ? 346 GLU A N     1 ? 
ATOM   2731 C CA    . GLU A 1 352 ? -19.36788 4.62847   3.21983   1.000 72.29783  ? 346 GLU A CA    1 ? 
ATOM   2732 C C     . GLU A 1 352 ? -19.76897 4.59802   4.68848   1.000 73.43094  ? 346 GLU A C     1 ? 
ATOM   2733 O O     . GLU A 1 352 ? -19.07373 3.99516   5.51358   1.000 72.34478  ? 346 GLU A O     1 ? 
ATOM   2734 C CB    . GLU A 1 352 ? -19.01395 3.22796   2.71917   1.000 70.95583  ? 346 GLU A CB    1 ? 
ATOM   2735 C CG    . GLU A 1 352 ? -19.06408 3.07998   1.20687   1.000 79.80612  ? 346 GLU A CG    1 ? 
ATOM   2736 C CD    . GLU A 1 352 ? -20.47241 3.19511   0.65443   1.000 87.87603  ? 346 GLU A CD    1 ? 
ATOM   2737 O OE1   . GLU A 1 352 ? -21.40269 2.62957   1.26800   1.000 73.49077  ? 346 GLU A OE1   1 ? 
ATOM   2738 O OE2   . GLU A 1 352 ? -20.64903 3.85391   -0.39260  1.000 84.44907  ? 346 GLU A OE2   1 ? 
ATOM   2739 N N     . ASP A 1 353 ? -20.88422 5.24906   5.01203   1.000 78.24363  ? 347 ASP A N     1 ? 
ATOM   2740 C CA    . ASP A 1 353 ? -21.43889 5.21318   6.36361   1.000 77.74751  ? 347 ASP A CA    1 ? 
ATOM   2741 C C     . ASP A 1 353 ? -21.88010 3.78622   6.65715   1.000 78.88871  ? 347 ASP A C     1 ? 
ATOM   2742 O O     . ASP A 1 353 ? -22.95635 3.35390   6.23940   1.000 87.11932  ? 347 ASP A O     1 ? 
ATOM   2743 C CB    . ASP A 1 353 ? -22.60058 6.19234   6.49304   1.000 81.07966  ? 347 ASP A CB    1 ? 
ATOM   2744 C CG    . ASP A 1 353 ? -23.11781 6.30698   7.91762   1.000 89.17615  ? 347 ASP A CG    1 ? 
ATOM   2745 O OD1   . ASP A 1 353 ? -22.58688 5.61511   8.81282   1.000 83.38738  ? 347 ASP A OD1   1 ? 
ATOM   2746 O OD2   . ASP A 1 353 ? -24.06172 7.09359   8.14235   1.000 98.48759  ? 347 ASP A OD2   1 ? 
ATOM   2747 N N     . VAL A 1 354 ? -21.04020 3.04418   7.38317   1.000 71.60867  ? 348 VAL A N     1 ? 
ATOM   2748 C CA    . VAL A 1 354 ? -21.30252 1.63108   7.63589   1.000 66.95837  ? 348 VAL A CA    1 ? 
ATOM   2749 C C     . VAL A 1 354 ? -22.19479 1.40907   8.85175   1.000 79.52189  ? 348 VAL A C     1 ? 
ATOM   2750 O O     . VAL A 1 354 ? -22.70214 0.29326   9.04276   1.000 81.78455  ? 348 VAL A O     1 ? 
ATOM   2751 C CB    . VAL A 1 354 ? -19.95176 0.88699   7.72780   1.000 69.94634  ? 348 VAL A CB    1 ? 
ATOM   2752 C CG1   . VAL A 1 354 ? -19.72001 0.27550   9.10643   1.000 76.12163  ? 348 VAL A CG1   1 ? 
ATOM   2753 C CG2   . VAL A 1 354 ? -19.86520 -0.16932  6.63793   1.000 68.20345  ? 348 VAL A CG2   1 ? 
ATOM   2754 N N     . LYS A 1 355 ? -22.43719 2.43866   9.66466   1.000 79.16144  ? 349 LYS A N     1 ? 
ATOM   2755 C CA    . LYS A 1 355 ? -23.44798 2.30299   10.70846  1.000 86.41132  ? 349 LYS A CA    1 ? 
ATOM   2756 C C     . LYS A 1 355 ? -24.84683 2.24398   10.10672  1.000 91.86712  ? 349 LYS A C     1 ? 
ATOM   2757 O O     . LYS A 1 355 ? -25.69860 1.47817   10.57259  1.000 89.20645  ? 349 LYS A O     1 ? 
ATOM   2758 C CB    . LYS A 1 355 ? -23.34231 3.45297   11.70897  1.000 83.23521  ? 349 LYS A CB    1 ? 
ATOM   2759 C CG    . LYS A 1 355 ? -24.31420 3.33921   12.87464  1.000 82.48257  ? 349 LYS A CG    1 ? 
ATOM   2760 C CD    . LYS A 1 355 ? -23.68745 3.80593   14.17854  1.000 84.11070  ? 349 LYS A CD    1 ? 
ATOM   2761 C CE    . LYS A 1 355 ? -23.19978 5.24145   14.07982  1.000 94.42162  ? 349 LYS A CE    1 ? 
ATOM   2762 N NZ    . LYS A 1 355 ? -22.73305 5.75884   15.39646  1.000 90.77196  ? 349 LYS A NZ    1 ? 
ATOM   2763 N N     . ALA A 1 356 ? -25.09948 3.04040   9.06798   1.000 84.31617  ? 350 ALA A N     1 ? 
ATOM   2764 C CA    . ALA A 1 356 ? -26.38531 3.02486   8.38305   1.000 77.79422  ? 350 ALA A CA    1 ? 
ATOM   2765 C C     . ALA A 1 356 ? -26.43518 2.00656   7.25335   1.000 94.33647  ? 350 ALA A C     1 ? 
ATOM   2766 O O     . ALA A 1 356 ? -27.52371 1.54213   6.89504   1.000 106.22626 ? 350 ALA A O     1 ? 
ATOM   2767 C CB    . ALA A 1 356 ? -26.70671 4.41642   7.83053   1.000 80.81952  ? 350 ALA A CB    1 ? 
ATOM   2768 N N     . ASN A 1 357 ? -25.28472 1.64978   6.68670   1.000 95.68565  ? 351 ASN A N     1 ? 
ATOM   2769 C CA    . ASN A 1 357 ? -25.19161 0.67361   5.60148   1.000 84.68288  ? 351 ASN A CA    1 ? 
ATOM   2770 C C     . ASN A 1 357 ? -24.16386 -0.38351  5.99012   1.000 81.89817  ? 351 ASN A C     1 ? 
ATOM   2771 O O     . ASN A 1 357 ? -23.04405 -0.40659  5.46625   1.000 83.58929  ? 351 ASN A O     1 ? 
ATOM   2772 C CB    . ASN A 1 357 ? -24.82051 1.36147   4.28703   1.000 86.85756  ? 351 ASN A CB    1 ? 
ATOM   2773 C CG    . ASN A 1 357 ? -25.06625 0.48542   3.07944   1.000 87.02249  ? 351 ASN A CG    1 ? 
ATOM   2774 O OD1   . ASN A 1 357 ? -26.04095 -0.26439  3.02922   1.000 89.91378  ? 351 ASN A OD1   1 ? 
ATOM   2775 N ND2   . ASN A 1 357 ? -24.18693 0.58548   2.08984   1.000 82.83517  ? 351 ASN A ND2   1 ? 
ATOM   2776 N N     . PRO A 1 358 ? -24.52024 -1.27952  6.90869   1.000 79.74687  ? 352 PRO A N     1 ? 
ATOM   2777 C CA    . PRO A 1 358 ? -23.52027 -2.18004  7.49438   1.000 80.75771  ? 352 PRO A CA    1 ? 
ATOM   2778 C C     . PRO A 1 358 ? -23.01675 -3.22448  6.51180   1.000 80.09307  ? 352 PRO A C     1 ? 
ATOM   2779 O O     . PRO A 1 358 ? -23.68036 -3.58829  5.53897   1.000 90.73046  ? 352 PRO A O     1 ? 
ATOM   2780 C CB    . PRO A 1 358 ? -24.27492 -2.84012  8.65598   1.000 78.46391  ? 352 PRO A CB    1 ? 
ATOM   2781 C CG    . PRO A 1 358 ? -25.45098 -1.94223  8.91547   1.000 80.99944  ? 352 PRO A CG    1 ? 
ATOM   2782 C CD    . PRO A 1 358 ? -25.82754 -1.41682  7.56839   1.000 78.78070  ? 352 PRO A CD    1 ? 
ATOM   2783 N N     . ILE A 1 359 ? -21.81048 -3.70801  6.79385   1.000 73.88469  ? 353 ILE A N     1 ? 
ATOM   2784 C CA    . ILE A 1 359 ? -21.22362 -4.81581  6.04856   1.000 81.37796  ? 353 ILE A CA    1 ? 
ATOM   2785 C C     . ILE A 1 359 ? -21.85850 -6.11041  6.53739   1.000 88.50197  ? 353 ILE A C     1 ? 
ATOM   2786 O O     . ILE A 1 359 ? -21.80014 -6.43089  7.72971   1.000 87.65767  ? 353 ILE A O     1 ? 
ATOM   2787 C CB    . ILE A 1 359 ? -19.69804 -4.85218  6.21696   1.000 77.25662  ? 353 ILE A CB    1 ? 
ATOM   2788 C CG1   . ILE A 1 359 ? -19.07642 -3.52746  5.77287   1.000 75.34391  ? 353 ILE A CG1   1 ? 
ATOM   2789 C CG2   . ILE A 1 359 ? -19.10293 -6.01490  5.43676   1.000 79.04168  ? 353 ILE A CG2   1 ? 
ATOM   2790 C CD1   . ILE A 1 359 ? -17.71417 -3.25723  6.37638   1.000 60.35562  ? 353 ILE A CD1   1 ? 
ATOM   2791 N N     . VAL A 1 360 ? -22.46900 -6.85523  5.62028   1.000 86.79856  ? 354 VAL A N     1 ? 
ATOM   2792 C CA    . VAL A 1 360 ? -23.11873 -8.11268  5.96151   1.000 88.20165  ? 354 VAL A CA    1 ? 
ATOM   2793 C C     . VAL A 1 360 ? -22.34954 -9.32843  5.45982   1.000 89.25830  ? 354 VAL A C     1 ? 
ATOM   2794 O O     . VAL A 1 360 ? -22.54462 -10.42817 6.00102   1.000 98.77681  ? 354 VAL A O     1 ? 
ATOM   2795 C CB    . VAL A 1 360 ? -24.57091 -8.14810  5.44076   1.000 87.20135  ? 354 VAL A CB    1 ? 
ATOM   2796 C CG1   . VAL A 1 360 ? -25.25992 -6.82223  5.71384   1.000 85.69744  ? 354 VAL A CG1   1 ? 
ATOM   2797 C CG2   . VAL A 1 360 ? -24.60066 -8.46725  3.95260   1.000 84.27787  ? 354 VAL A CG2   1 ? 
ATOM   2798 N N     . GLU A 1 361 ? -21.48132 -9.16987  4.46566   1.000 90.65207  ? 355 GLU A N     1 ? 
ATOM   2799 C CA    . GLU A 1 361 ? -20.73437 -10.26514 3.86589   1.000 89.26211  ? 355 GLU A CA    1 ? 
ATOM   2800 C C     . GLU A 1 361 ? -19.66472 -9.66206  2.97166   1.000 83.99828  ? 355 GLU A C     1 ? 
ATOM   2801 O O     . GLU A 1 361 ? -19.87066 -8.60154  2.37780   1.000 81.94711  ? 355 GLU A O     1 ? 
ATOM   2802 C CB    . GLU A 1 361 ? -21.65244 -11.19740 3.05841   1.000 92.89179  ? 355 GLU A CB    1 ? 
ATOM   2803 C CG    . GLU A 1 361 ? -20.93789 -12.07867 2.03970   1.000 96.47684  ? 355 GLU A CG    1 ? 
ATOM   2804 C CD    . GLU A 1 361 ? -21.63590 -13.40463 1.81299   1.000 107.84783 ? 355 GLU A CD    1 ? 
ATOM   2805 O OE1   . GLU A 1 361 ? -22.88280 -13.41827 1.74700   1.000 103.89173 ? 355 GLU A OE1   1 ? 
ATOM   2806 O OE2   . GLU A 1 361 ? -20.93667 -14.43330 1.69593   1.000 110.79333 ? 355 GLU A OE2   1 ? 
ATOM   2807 N N     . ILE A 1 362 ? -18.51570 -10.32564 2.90029   1.000 77.78203  ? 356 ILE A N     1 ? 
ATOM   2808 C CA    . ILE A 1 362 ? -17.47260 -9.96322  1.95035   1.000 83.33650  ? 356 ILE A CA    1 ? 
ATOM   2809 C C     . ILE A 1 362 ? -17.17440 -11.19190 1.09918   1.000 84.10850  ? 356 ILE A C     1 ? 
ATOM   2810 O O     . ILE A 1 362 ? -16.81747 -12.25394 1.62538   1.000 78.15486  ? 356 ILE A O     1 ? 
ATOM   2811 C CB    . ILE A 1 362 ? -16.21602 -9.41281  2.64932   1.000 81.43578  ? 356 ILE A CB    1 ? 
ATOM   2812 C CG1   . ILE A 1 362 ? -15.57612 -10.43514 3.58270   1.000 79.71885  ? 356 ILE A CG1   1 ? 
ATOM   2813 C CG2   . ILE A 1 362 ? -16.57197 -8.18986  3.47274   1.000 79.80724  ? 356 ILE A CG2   1 ? 
ATOM   2814 C CD1   . ILE A 1 362 ? -14.28070 -9.95314  4.18395   1.000 84.36808  ? 356 ILE A CD1   1 ? 
ATOM   2815 N N     . LYS A 1 363 ? -17.36894 -11.06059 -0.20966  1.000 80.59211  ? 357 LYS A N     1 ? 
ATOM   2816 C CA    . LYS A 1 363 ? -17.18238 -12.17809 -1.12385  1.000 78.32367  ? 357 LYS A CA    1 ? 
ATOM   2817 C C     . LYS A 1 363 ? -15.69825 -12.30904 -1.46055  1.000 81.76493  ? 357 LYS A C     1 ? 
ATOM   2818 O O     . LYS A 1 363 ? -14.83901 -11.66262 -0.85484  1.000 85.08147  ? 357 LYS A O     1 ? 
ATOM   2819 C CB    . LYS A 1 363 ? -18.05614 -11.99978 -2.36299  1.000 78.67556  ? 357 LYS A CB    1 ? 
ATOM   2820 C CG    . LYS A 1 363 ? -19.46807 -12.54824 -2.19788  1.000 84.60348  ? 357 LYS A CG    1 ? 
ATOM   2821 C CD    . LYS A 1 363 ? -20.47437 -11.78864 -3.04806  1.000 94.89548  ? 357 LYS A CD    1 ? 
ATOM   2822 C CE    . LYS A 1 363 ? -20.65358 -12.43853 -4.41080  1.000 100.98606 ? 357 LYS A CE    1 ? 
ATOM   2823 N NZ    . LYS A 1 363 ? -20.70557 -11.43092 -5.50547  1.000 97.94340  ? 357 LYS A NZ    1 ? 
ATOM   2824 N N     . GLU A 1 364 ? -15.37885 -13.15987 -2.43842  1.000 81.97914  ? 358 GLU A N     1 ? 
ATOM   2825 C CA    . GLU A 1 364 ? -13.98380 -13.46935 -2.72870  1.000 83.10860  ? 358 GLU A CA    1 ? 
ATOM   2826 C C     . GLU A 1 364 ? -13.21253 -12.27145 -3.26482  1.000 82.32784  ? 358 GLU A C     1 ? 
ATOM   2827 O O     . GLU A 1 364 ? -11.98067 -12.25292 -3.17012  1.000 75.20201  ? 358 GLU A O     1 ? 
ATOM   2828 C CB    . GLU A 1 364 ? -13.89406 -14.62525 -3.72621  1.000 80.64658  ? 358 GLU A CB    1 ? 
ATOM   2829 C CG    . GLU A 1 364 ? -14.40906 -14.29269 -5.11566  1.000 84.35635  ? 358 GLU A CG    1 ? 
ATOM   2830 C CD    . GLU A 1 364 ? -13.63549 -15.00851 -6.20553  1.000 93.10774  ? 358 GLU A CD    1 ? 
ATOM   2831 O OE1   . GLU A 1 364 ? -12.42435 -14.73844 -6.35052  1.000 94.14600  ? 358 GLU A OE1   1 ? 
ATOM   2832 O OE2   . GLU A 1 364 ? -14.23694 -15.84202 -6.91539  1.000 86.04392  ? 358 GLU A OE2   1 ? 
ATOM   2833 N N     . ASP A 1 365 ? -13.90249 -11.26967 -3.81544  1.000 78.70562  ? 359 ASP A N     1 ? 
ATOM   2834 C CA    . ASP A 1 365 ? -13.21182 -10.14402 -4.43145  1.000 71.08464  ? 359 ASP A CA    1 ? 
ATOM   2835 C C     . ASP A 1 365 ? -13.85186 -8.80267  -4.08951  1.000 73.48103  ? 359 ASP A C     1 ? 
ATOM   2836 O O     . ASP A 1 365 ? -13.57073 -7.80635  -4.76739  1.000 68.49427  ? 359 ASP A O     1 ? 
ATOM   2837 C CB    . ASP A 1 365 ? -13.16995 -10.31188 -5.95415  1.000 76.80022  ? 359 ASP A CB    1 ? 
ATOM   2838 C CG    . ASP A 1 365 ? -14.54824 -10.52783 -6.55335  1.000 85.24256  ? 359 ASP A CG    1 ? 
ATOM   2839 O OD1   . ASP A 1 365 ? -15.47989 -10.86958 -5.79447  1.000 80.20972  ? 359 ASP A OD1   1 ? 
ATOM   2840 O OD2   . ASP A 1 365 ? -14.70187 -10.35431 -7.78107  1.000 79.14089  ? 359 ASP A OD2   1 ? 
ATOM   2841 N N     . CYS A 1 366 ? -14.69598 -8.74029  -3.06264  1.000 68.79924  ? 360 CYS A N     1 ? 
ATOM   2842 C CA    . CYS A 1 366 ? -15.43024 -7.51304  -2.79020  1.000 76.61023  ? 360 CYS A CA    1 ? 
ATOM   2843 C C     . CYS A 1 366 ? -15.95912 -7.52850  -1.36352  1.000 73.67561  ? 360 CYS A C     1 ? 
ATOM   2844 O O     . CYS A 1 366 ? -15.91732 -8.54595  -0.66783  1.000 73.84864  ? 360 CYS A O     1 ? 
ATOM   2845 C CB    . CYS A 1 366 ? -16.58073 -7.32569  -3.78428  1.000 77.17852  ? 360 CYS A CB    1 ? 
ATOM   2846 S SG    . CYS A 1 366 ? -17.84660 -8.61175  -3.69915  1.000 81.03923  ? 360 CYS A SG    1 ? 
ATOM   2847 N N     . VAL A 1 367 ? -16.45584 -6.36792  -0.94137  1.000 79.34621  ? 361 VAL A N     1 ? 
ATOM   2848 C CA    . VAL A 1 367 ? -17.17105 -6.19921  0.31756   1.000 78.49012  ? 361 VAL A CA    1 ? 
ATOM   2849 C C     . VAL A 1 367 ? -18.61554 -5.86119  -0.02177  1.000 77.77265  ? 361 VAL A C     1 ? 
ATOM   2850 O O     . VAL A 1 367 ? -18.87221 -4.96332  -0.83301  1.000 81.31792  ? 361 VAL A O     1 ? 
ATOM   2851 C CB    . VAL A 1 367 ? -16.53956 -5.09521  1.18488   1.000 67.32012  ? 361 VAL A CB    1 ? 
ATOM   2852 C CG1   . VAL A 1 367 ? -17.46160 -4.72677  2.34255   1.000 65.29931  ? 361 VAL A CG1   1 ? 
ATOM   2853 C CG2   . VAL A 1 367 ? -15.16589 -5.51668  1.68463   1.000 69.95315  ? 361 VAL A CG2   1 ? 
ATOM   2854 N N     . VAL A 1 368 ? -19.55554 -6.58130  0.58336   1.000 71.48366  ? 362 VAL A N     1 ? 
ATOM   2855 C CA    . VAL A 1 368 ? -20.97958 -6.38532  0.33297   1.000 75.00449  ? 362 VAL A CA    1 ? 
ATOM   2856 C C     . VAL A 1 368 ? -21.59417 -5.73486  1.56353   1.000 77.86249  ? 362 VAL A C     1 ? 
ATOM   2857 O O     . VAL A 1 368 ? -21.56622 -6.30882  2.65961   1.000 78.83313  ? 362 VAL A O     1 ? 
ATOM   2858 C CB    . VAL A 1 368 ? -21.68761 -7.70686  -0.00262  1.000 79.16026  ? 362 VAL A CB    1 ? 
ATOM   2859 C CG1   . VAL A 1 368 ? -23.03716 -7.43685  -0.65024  1.000 88.42472  ? 362 VAL A CG1   1 ? 
ATOM   2860 C CG2   . VAL A 1 368 ? -20.81295 -8.56474  -0.90415  1.000 81.35508  ? 362 VAL A CG2   1 ? 
ATOM   2861 N N     . THR A 1 369 ? -22.14701 -4.53877  1.38347   1.000 75.61966  ? 363 THR A N     1 ? 
ATOM   2862 C CA    . THR A 1 369 ? -22.84863 -3.85101  2.45260   1.000 83.08658  ? 363 THR A CA    1 ? 
ATOM   2863 C C     . THR A 1 369 ? -24.32246 -4.25802  2.45146   1.000 93.75925  ? 363 THR A C     1 ? 
ATOM   2864 O O     . THR A 1 369 ? -24.77190 -5.06223  1.63128   1.000 92.57118  ? 363 THR A O     1 ? 
ATOM   2865 C CB    . THR A 1 369 ? -22.68289 -2.33812  2.31546   1.000 83.16135  ? 363 THR A CB    1 ? 
ATOM   2866 O OG1   . THR A 1 369 ? -23.23577 -1.90372  1.06715   1.000 90.08751  ? 363 THR A OG1   1 ? 
ATOM   2867 C CG2   . THR A 1 369 ? -21.21042 -1.95573  2.37509   1.000 78.15727  ? 363 THR A CG2   1 ? 
ATOM   2868 N N     . ALA A 1 370 ? -25.08916 -3.69142  3.38763   1.000 86.88803  ? 364 ALA A N     1 ? 
ATOM   2869 C CA    . ALA A 1 370 ? -26.48069 -4.10046  3.55694   1.000 80.97296  ? 364 ALA A CA    1 ? 
ATOM   2870 C C     . ALA A 1 370 ? -27.33801 -3.72959  2.35412   1.000 88.80873  ? 364 ALA A C     1 ? 
ATOM   2871 O O     . ALA A 1 370 ? -28.29556 -4.44440  2.03486   1.000 91.42355  ? 364 ALA A O     1 ? 
ATOM   2872 C CB    . ALA A 1 370 ? -27.06047 -3.47917  4.82658   1.000 77.04997  ? 364 ALA A CB    1 ? 
ATOM   2873 N N     . ASP A 1 371 ? -27.01803 -2.62282  1.68059   1.000 88.47463  ? 365 ASP A N     1 ? 
ATOM   2874 C CA    . ASP A 1 371 ? -27.77998 -2.19748  0.51218   1.000 90.38873  ? 365 ASP A CA    1 ? 
ATOM   2875 C C     . ASP A 1 371 ? -27.58157 -3.11202  -0.69109  1.000 87.91372  ? 365 ASP A C     1 ? 
ATOM   2876 O O     . ASP A 1 371 ? -28.33289 -2.99435  -1.66515  1.000 87.95772  ? 365 ASP A O     1 ? 
ATOM   2877 C CB    . ASP A 1 371 ? -27.41510 -0.74992  0.16107   1.000 86.30909  ? 365 ASP A CB    1 ? 
ATOM   2878 C CG    . ASP A 1 371 ? -25.93987 -0.57573  -0.15131  1.000 89.14234  ? 365 ASP A CG    1 ? 
ATOM   2879 O OD1   . ASP A 1 371 ? -25.17925 -1.55394  -0.00019  1.000 94.51947  ? 365 ASP A OD1   1 ? 
ATOM   2880 O OD2   . ASP A 1 371 ? -25.53445 0.54942   -0.51463  1.000 86.57973  ? 365 ASP A OD2   1 ? 
ATOM   2881 N N     . GLY A 1 372 ? -26.60759 -4.02141  -0.64257  1.000 87.58798  ? 366 GLY A N     1 ? 
ATOM   2882 C CA    . GLY A 1 372 ? -26.37318 -4.98062  -1.69490  1.000 87.48812  ? 366 GLY A CA    1 ? 
ATOM   2883 C C     . GLY A 1 372 ? -25.20505 -4.65683  -2.60248  1.000 91.84041  ? 366 GLY A C     1 ? 
ATOM   2884 O O     . GLY A 1 372 ? -24.75736 -5.53624  -3.34808  1.000 92.55003  ? 366 GLY A O     1 ? 
ATOM   2885 N N     . VAL A 1 373 ? -24.70056 -3.42406  -2.56029  1.000 86.92824  ? 367 VAL A N     1 ? 
ATOM   2886 C CA    . VAL A 1 373 ? -23.59396 -3.03931  -3.42795  1.000 80.41373  ? 367 VAL A CA    1 ? 
ATOM   2887 C C     . VAL A 1 373 ? -22.33422 -3.79993  -3.04925  1.000 76.83500  ? 367 VAL A C     1 ? 
ATOM   2888 O O     . VAL A 1 373 ? -21.94530 -3.85990  -1.87277  1.000 77.67708  ? 367 VAL A O     1 ? 
ATOM   2889 C CB    . VAL A 1 373 ? -23.36858 -1.52133  -3.38274  1.000 75.76272  ? 367 VAL A CB    1 ? 
ATOM   2890 C CG1   . VAL A 1 373 ? -22.49457 -1.10024  -4.55489  1.000 71.88447  ? 367 VAL A CG1   1 ? 
ATOM   2891 C CG2   . VAL A 1 373 ? -24.71647 -0.78460  -3.44197  1.000 76.62644  ? 367 VAL A CG2   1 ? 
ATOM   2892 N N     . GLU A 1 374 ? -21.68796 -4.38949  -4.05236  1.000 76.72421  ? 368 GLU A N     1 ? 
ATOM   2893 C CA    . GLU A 1 374 ? -20.42872 -5.09819  -3.88199  1.000 77.15162  ? 368 GLU A CA    1 ? 
ATOM   2894 C C     . GLU A 1 374 ? -19.28231 -4.12956  -4.14570  1.000 74.95127  ? 368 GLU A C     1 ? 
ATOM   2895 O O     . GLU A 1 374 ? -19.19287 -3.54589  -5.23195  1.000 74.38445  ? 368 GLU A O     1 ? 
ATOM   2896 C CB    . GLU A 1 374 ? -20.35639 -6.29663  -4.82738  1.000 81.42982  ? 368 GLU A CB    1 ? 
ATOM   2897 C CG    . GLU A 1 374 ? -21.69693 -6.97595  -5.06627  1.000 95.88918  ? 368 GLU A CG    1 ? 
ATOM   2898 C CD    . GLU A 1 374 ? -21.55533 -8.33656  -5.71798  1.000 99.59287  ? 368 GLU A CD    1 ? 
ATOM   2899 O OE1   . GLU A 1 374 ? -20.61774 -8.51362  -6.52317  1.000 97.71009  ? 368 GLU A OE1   1 ? 
ATOM   2900 O OE2   . GLU A 1 374 ? -22.38085 -9.22797  -5.42663  1.000 93.81513  ? 368 GLU A OE2   1 ? 
ATOM   2901 N N     . HIS A 1 375 ? -18.41671 -3.95270  -3.15198  1.000 75.94265  ? 369 HIS A N     1 ? 
ATOM   2902 C CA    . HIS A 1 375 ? -17.28898 -3.02694  -3.24150  1.000 74.20892  ? 369 HIS A CA    1 ? 
ATOM   2903 C C     . HIS A 1 375 ? -16.05465 -3.83939  -3.61643  1.000 71.68544  ? 369 HIS A C     1 ? 
ATOM   2904 O O     . HIS A 1 375 ? -15.37233 -4.39617  -2.75748  1.000 76.32709  ? 369 HIS A O     1 ? 
ATOM   2905 C CB    . HIS A 1 375 ? -17.09887 -2.27850  -1.92741  1.000 72.80777  ? 369 HIS A CB    1 ? 
ATOM   2906 C CG    . HIS A 1 375 ? -18.30030 -1.49419  -1.50012  1.000 71.90283  ? 369 HIS A CG    1 ? 
ATOM   2907 N ND1   . HIS A 1 375 ? -18.55820 -0.21986  -1.95655  1.000 78.74243  ? 369 HIS A ND1   1 ? 
ATOM   2908 C CD2   . HIS A 1 375 ? -19.31674 -1.80671  -0.66182  1.000 70.24901  ? 369 HIS A CD2   1 ? 
ATOM   2909 C CE1   . HIS A 1 375 ? -19.67981 0.22099   -1.41482  1.000 74.09720  ? 369 HIS A CE1   1 ? 
ATOM   2910 N NE2   . HIS A 1 375 ? -20.16012 -0.72286  -0.62580  1.000 71.67834  ? 369 HIS A NE2   1 ? 
ATOM   2911 N N     . LYS A 1 376 ? -15.77044 -3.90464  -4.91582  1.000 67.40451  ? 370 LYS A N     1 ? 
ATOM   2912 C CA    . LYS A 1 376 ? -14.65201 -4.69882  -5.41121  1.000 70.48458  ? 370 LYS A CA    1 ? 
ATOM   2913 C C     . LYS A 1 376 ? -13.33293 -4.10695  -4.92748  1.000 65.77404  ? 370 LYS A C     1 ? 
ATOM   2914 O O     . LYS A 1 376 ? -12.98669 -2.97367  -5.27724  1.000 63.36568  ? 370 LYS A O     1 ? 
ATOM   2915 C CB    . LYS A 1 376 ? -14.68825 -4.76204  -6.93594  1.000 72.69512  ? 370 LYS A CB    1 ? 
ATOM   2916 C CG    . LYS A 1 376 ? -15.98680 -5.31933  -7.50182  1.000 74.41279  ? 370 LYS A CG    1 ? 
ATOM   2917 C CD    . LYS A 1 376 ? -15.72422 -6.41648  -8.52116  1.000 78.64670  ? 370 LYS A CD    1 ? 
ATOM   2918 C CE    . LYS A 1 376 ? -17.02072 -6.92493  -9.13158  1.000 75.21146  ? 370 LYS A CE    1 ? 
ATOM   2919 N NZ    . LYS A 1 376 ? -16.78522 -8.04092  -10.08898 1.000 69.00056  ? 370 LYS A NZ    1 ? 
ATOM   2920 N N     . LEU A 1 377 ? -12.59703 -4.87323  -4.12542  1.000 65.68003  ? 371 LEU A N     1 ? 
ATOM   2921 C CA    . LEU A 1 377 ? -11.33595 -4.42904  -3.55037  1.000 63.03701  ? 371 LEU A CA    1 ? 
ATOM   2922 C C     . LEU A 1 377 ? -10.21078 -5.37261  -3.94610  1.000 65.38845  ? 371 LEU A C     1 ? 
ATOM   2923 O O     . LEU A 1 377 ? -10.40289 -6.59049  -4.02148  1.000 70.23199  ? 371 LEU A O     1 ? 
ATOM   2924 C CB    . LEU A 1 377 ? -11.41118 -4.35249  -2.02113  1.000 58.81303  ? 371 LEU A CB    1 ? 
ATOM   2925 C CG    . LEU A 1 377 ? -12.61096 -3.65142  -1.38745  1.000 60.27236  ? 371 LEU A CG    1 ? 
ATOM   2926 C CD1   . LEU A 1 377 ? -12.47733 -3.64805  0.12485   1.000 59.42377  ? 371 LEU A CD1   1 ? 
ATOM   2927 C CD2   . LEU A 1 377 ? -12.74763 -2.23550  -1.91926  1.000 58.02257  ? 371 LEU A CD2   1 ? 
ATOM   2928 N N     . ASP A 1 378 ? -9.03574  -4.79884  -4.19444  1.000 67.88187  ? 372 ASP A N     1 ? 
ATOM   2929 C CA    . ASP A 1 378 ? -7.81286  -5.56888  -4.36263  1.000 58.08078  ? 372 ASP A CA    1 ? 
ATOM   2930 C C     . ASP A 1 378 ? -7.07676  -5.78587  -3.04932  1.000 64.55295  ? 372 ASP A C     1 ? 
ATOM   2931 O O     . ASP A 1 378 ? -6.17638  -6.63052  -2.99186  1.000 71.29678  ? 372 ASP A O     1 ? 
ATOM   2932 C CB    . ASP A 1 378 ? -6.87784  -4.86949  -5.35491  1.000 57.02592  ? 372 ASP A CB    1 ? 
ATOM   2933 C CG    . ASP A 1 378 ? -7.20837  -5.19538  -6.79477  1.000 72.00306  ? 372 ASP A CG    1 ? 
ATOM   2934 O OD1   . ASP A 1 378 ? -7.24698  -6.39522  -7.13915  1.000 76.20532  ? 372 ASP A OD1   1 ? 
ATOM   2935 O OD2   . ASP A 1 378 ? -7.43215  -4.25097  -7.58051  1.000 68.19284  ? 372 ASP A OD2   1 ? 
ATOM   2936 N N     . MET A 1 379 ? -7.44194  -5.04944  -2.00115  1.000 67.02171  ? 373 MET A N     1 ? 
ATOM   2937 C CA    . MET A 1 379 ? -6.74779  -5.11479  -0.72230  1.000 64.65823  ? 373 MET A CA    1 ? 
ATOM   2938 C C     . MET A 1 379 ? -7.64796  -4.51056  0.34407   1.000 56.51839  ? 373 MET A C     1 ? 
ATOM   2939 O O     . MET A 1 379 ? -8.22989  -3.44254  0.13089   1.000 57.14074  ? 373 MET A O     1 ? 
ATOM   2940 C CB    . MET A 1 379 ? -5.40862  -4.37190  -0.79195  1.000 65.09771  ? 373 MET A CB    1 ? 
ATOM   2941 C CG    . MET A 1 379 ? -4.68173  -4.24570  0.53350   1.000 70.16534  ? 373 MET A CG    1 ? 
ATOM   2942 S SD    . MET A 1 379 ? -3.81844  -2.67051  0.67466   1.000 80.51313  ? 373 MET A SD    1 ? 
ATOM   2943 C CE    . MET A 1 379 ? -2.58438  -2.85048  -0.61109  1.000 63.44268  ? 373 MET A CE    1 ? 
ATOM   2944 N N     . LEU A 1 380 ? -7.76435  -5.19402  1.48095   1.000 55.16643  ? 374 LEU A N     1 ? 
ATOM   2945 C CA    . LEU A 1 380 ? -8.63033  -4.77012  2.57736   1.000 59.46674  ? 374 LEU A CA    1 ? 
ATOM   2946 C C     . LEU A 1 380 ? -7.77691  -4.56869  3.82305   1.000 59.41603  ? 374 LEU A C     1 ? 
ATOM   2947 O O     . LEU A 1 380 ? -7.22371  -5.53192  4.36489   1.000 62.52617  ? 374 LEU A O     1 ? 
ATOM   2948 C CB    . LEU A 1 380 ? -9.73560  -5.79541  2.82713   1.000 64.85459  ? 374 LEU A CB    1 ? 
ATOM   2949 C CG    . LEU A 1 380 ? -10.69938 -5.49535  3.97627   1.000 70.58798  ? 374 LEU A CG    1 ? 
ATOM   2950 C CD1   . LEU A 1 380 ? -11.57272 -4.29525  3.64669   1.000 64.86900  ? 374 LEU A CD1   1 ? 
ATOM   2951 C CD2   . LEU A 1 380 ? -11.55303 -6.71434  4.28837   1.000 61.53489  ? 374 LEU A CD2   1 ? 
ATOM   2952 N N     . ILE A 1 381 ? -7.67357  -3.32219  4.27476   1.000 66.65211  ? 375 ILE A N     1 ? 
ATOM   2953 C CA    . ILE A 1 381 ? -6.89740  -2.98043  5.46138   1.000 63.18249  ? 375 ILE A CA    1 ? 
ATOM   2954 C C     . ILE A 1 381 ? -7.82703  -2.95640  6.66666   1.000 67.84394  ? 375 ILE A C     1 ? 
ATOM   2955 O O     . ILE A 1 381 ? -8.92462  -2.38897  6.60638   1.000 65.99692  ? 375 ILE A O     1 ? 
ATOM   2956 C CB    . ILE A 1 381 ? -6.18626  -1.62828  5.28354   1.000 57.10627  ? 375 ILE A CB    1 ? 
ATOM   2957 C CG1   . ILE A 1 381 ? -5.24479  -1.67662  4.07924   1.000 55.27242  ? 375 ILE A CG1   1 ? 
ATOM   2958 C CG2   . ILE A 1 381 ? -5.41914  -1.25098  6.54339   1.000 49.56305  ? 375 ILE A CG2   1 ? 
ATOM   2959 C CD1   . ILE A 1 381 ? -4.69112  -0.32849  3.68516   1.000 48.75149  ? 375 ILE A CD1   1 ? 
ATOM   2960 N N     . CYS A 1 382 ? -7.38913  -3.57089  7.76305   1.000 73.01319  ? 376 CYS A N     1 ? 
ATOM   2961 C CA    . CYS A 1 382 ? -8.17204  -3.66287  8.99339   1.000 74.44836  ? 376 CYS A CA    1 ? 
ATOM   2962 C C     . CYS A 1 382 ? -7.53564  -2.76294  10.04872  1.000 71.06256  ? 376 CYS A C     1 ? 
ATOM   2963 O O     . CYS A 1 382 ? -6.56944  -3.15208  10.71063  1.000 74.33316  ? 376 CYS A O     1 ? 
ATOM   2964 C CB    . CYS A 1 382 ? -8.25782  -5.10839  9.47505   1.000 78.67515  ? 376 CYS A CB    1 ? 
ATOM   2965 S SG    . CYS A 1 382 ? -9.39025  -6.14657  8.52052   1.000 85.98931  ? 376 CYS A SG    1 ? 
ATOM   2966 N N     . ALA A 1 383 ? -8.08203  -1.55803  10.20253  1.000 73.05042  ? 377 ALA A N     1 ? 
ATOM   2967 C CA    . ALA A 1 383 ? -7.65177  -0.65107  11.25927  1.000 77.13013  ? 377 ALA A CA    1 ? 
ATOM   2968 C C     . ALA A 1 383 ? -8.71893  -0.59160  12.34370  1.000 85.52840  ? 377 ALA A C     1 ? 
ATOM   2969 O O     . ALA A 1 383 ? -9.24631  0.48213   12.65347  1.000 81.55247  ? 377 ALA A O     1 ? 
ATOM   2970 C CB    . ALA A 1 383 ? -7.36977  0.74165   10.69589  1.000 72.70899  ? 377 ALA A CB    1 ? 
ATOM   2971 N N     . THR A 1 384 ? -9.03485  -1.74576  12.92823  1.000 89.28798  ? 378 THR A N     1 ? 
ATOM   2972 C CA    . THR A 1 384 ? -10.18745 -1.90099  13.80386  1.000 92.56090  ? 378 THR A CA    1 ? 
ATOM   2973 C C     . THR A 1 384 ? -9.83404  -1.83681  15.28518  1.000 99.60836  ? 378 THR A C     1 ? 
ATOM   2974 O O     . THR A 1 384 ? -10.71122 -2.04880  16.12787  1.000 100.66931 ? 378 THR A O     1 ? 
ATOM   2975 C CB    . THR A 1 384 ? -10.89673 -3.22095  13.49754  1.000 98.23397  ? 378 THR A CB    1 ? 
ATOM   2976 O OG1   . THR A 1 384 ? -9.97567  -4.12322  12.87111  1.000 92.64850  ? 378 THR A OG1   1 ? 
ATOM   2977 C CG2   . THR A 1 384 ? -12.07604 -2.98609  12.56919  1.000 88.37804  ? 378 THR A CG2   1 ? 
ATOM   2978 N N     . GLY A 1 385 ? -8.58369  -1.55536  15.62365  1.000 100.94719 ? 379 GLY A N     1 ? 
ATOM   2979 C CA    . GLY A 1 385 ? -8.20300  -1.41911  17.01447  1.000 105.93210 ? 379 GLY A CA    1 ? 
ATOM   2980 C C     . GLY A 1 385 ? -7.85619  -2.73854  17.67260  1.000 109.63033 ? 379 GLY A C     1 ? 
ATOM   2981 O O     . GLY A 1 385 ? -7.62601  -3.76651  17.02782  1.000 110.66404 ? 379 GLY A O     1 ? 
ATOM   2982 N N     . PHE A 1 386 ? -7.82184  -2.69612  19.00316  1.000 113.61417 ? 380 PHE A N     1 ? 
ATOM   2983 C CA    . PHE A 1 386 ? -7.39370  -3.83020  19.81359  1.000 120.07293 ? 380 PHE A CA    1 ? 
ATOM   2984 C C     . PHE A 1 386 ? -8.30684  -3.93025  21.03138  1.000 119.10834 ? 380 PHE A C     1 ? 
ATOM   2985 O O     . PHE A 1 386 ? -9.31042  -3.21944  21.14393  1.000 122.45458 ? 380 PHE A O     1 ? 
ATOM   2986 C CB    . PHE A 1 386 ? -5.92129  -3.68870  20.22910  1.000 118.02529 ? 380 PHE A CB    1 ? 
ATOM   2987 C CG    . PHE A 1 386 ? -5.04797  -3.04768  19.18630  1.000 112.19858 ? 380 PHE A CG    1 ? 
ATOM   2988 C CD1   . PHE A 1 386 ? -4.94623  -1.66773  19.09352  1.000 112.71955 ? 380 PHE A CD1   1 ? 
ATOM   2989 C CD2   . PHE A 1 386 ? -4.32741  -3.82708  18.29881  1.000 112.07203 ? 380 PHE A CD2   1 ? 
ATOM   2990 C CE1   . PHE A 1 386 ? -4.14554  -1.08048  18.13249  1.000 109.61984 ? 380 PHE A CE1   1 ? 
ATOM   2991 C CE2   . PHE A 1 386 ? -3.52464  -3.24459  17.33900  1.000 109.44977 ? 380 PHE A CE2   1 ? 
ATOM   2992 C CZ    . PHE A 1 386 ? -3.43249  -1.87099  17.25529  1.000 102.94572 ? 380 PHE A CZ    1 ? 
ATOM   2993 N N     . ASP A 1 387 ? -7.94983  -4.82431  21.95137  1.000 120.25759 ? 381 ASP A N     1 ? 
ATOM   2994 C CA    . ASP A 1 387 ? -8.64350  -4.95902  23.22086  1.000 117.49424 ? 381 ASP A CA    1 ? 
ATOM   2995 C C     . ASP A 1 387 ? -7.99287  -4.05102  24.26479  1.000 121.66316 ? 381 ASP A C     1 ? 
ATOM   2996 O O     . ASP A 1 387 ? -7.04872  -3.30991  23.98082  1.000 123.12790 ? 381 ASP A O     1 ? 
ATOM   2997 C CB    . ASP A 1 387 ? -8.64973  -6.41906  23.67354  1.000 115.78565 ? 381 ASP A CB    1 ? 
ATOM   2998 C CG    . ASP A 1 387 ? -9.29325  -7.34334  22.65570  1.000 122.42497 ? 381 ASP A CG    1 ? 
ATOM   2999 O OD1   . ASP A 1 387 ? -9.08638  -7.13347  21.44170  1.000 122.63148 ? 381 ASP A OD1   1 ? 
ATOM   3000 O OD2   . ASP A 1 387 ? -10.00716 -8.28058  23.07062  1.000 116.87023 ? 381 ASP A OD2   1 ? 
ATOM   3001 N N     . ALA A 1 388 ? -8.49932  -4.11172  25.49415  1.000 113.54441 ? 382 ALA A N     1 ? 
ATOM   3002 C CA    . ALA A 1 388 ? -8.04223  -3.21875  26.54721  1.000 107.20697 ? 382 ALA A CA    1 ? 
ATOM   3003 C C     . ALA A 1 388 ? -6.74859  -3.73868  27.17470  1.000 108.95502 ? 382 ALA A C     1 ? 
ATOM   3004 O O     . ALA A 1 388 ? -6.17644  -4.74719  26.75152  1.000 111.37319 ? 382 ALA A O     1 ? 
ATOM   3005 C CB    . ALA A 1 388 ? -9.13447  -3.03782  27.59832  1.000 99.39156  ? 382 ALA A CB    1 ? 
ATOM   3006 N N     . VAL A 1 389 ? -6.28295  -3.03123  28.20833  1.000 99.94171  ? 383 VAL A N     1 ? 
ATOM   3007 C CA    . VAL A 1 389 ? -5.00646  -3.36348  28.83522  1.000 100.26491 ? 383 VAL A CA    1 ? 
ATOM   3008 C C     . VAL A 1 389 ? -5.08452  -4.69354  29.57256  1.000 102.25239 ? 383 VAL A C     1 ? 
ATOM   3009 O O     . VAL A 1 389 ? -4.09504  -5.43360  29.63544  1.000 103.66276 ? 383 VAL A O     1 ? 
ATOM   3010 C CB    . VAL A 1 389 ? -4.56233  -2.22791  29.77782  1.000 103.24117 ? 383 VAL A CB    1 ? 
ATOM   3011 C CG1   . VAL A 1 389 ? -4.34226  -0.94740  28.99955  1.000 103.68660 ? 383 VAL A CG1   1 ? 
ATOM   3012 C CG2   . VAL A 1 389 ? -5.58830  -2.00594  30.87951  1.000 96.82909  ? 383 VAL A CG2   1 ? 
ATOM   3013 N N     . ASP A 1 390 ? -6.24878  -5.02258  30.13835  1.000 105.56211 ? 384 ASP A N     1 ? 
ATOM   3014 C CA    . ASP A 1 390 ? -6.38561  -6.26696  30.88671  1.000 104.64160 ? 384 ASP A CA    1 ? 
ATOM   3015 C C     . ASP A 1 390 ? -6.23515  -7.48297  29.98361  1.000 106.81768 ? 384 ASP A C     1 ? 
ATOM   3016 O O     . ASP A 1 390 ? -5.83912  -8.55705  30.45102  1.000 108.65976 ? 384 ASP A O     1 ? 
ATOM   3017 C CB    . ASP A 1 390 ? -7.73507  -6.29552  31.60412  1.000 105.57909 ? 384 ASP A CB    1 ? 
ATOM   3018 C CG    . ASP A 1 390 ? -8.89019  -5.97955  30.67730  1.000 118.82755 ? 384 ASP A CG    1 ? 
ATOM   3019 O OD1   . ASP A 1 390 ? -8.63130  -5.50178  29.55393  1.000 132.14725 ? 384 ASP A OD1   1 ? 
ATOM   3020 O OD2   . ASP A 1 390 ? -10.05431 -6.20347  31.07003  1.000 126.10307 ? 384 ASP A OD2   1 ? 
ATOM   3021 N N     . GLY A 1 391 ? -6.54033  -7.33434  28.69251  1.000 103.79087 ? 385 GLY A N     1 ? 
ATOM   3022 C CA    . GLY A 1 391 ? -6.37047  -8.44466  27.77006  1.000 95.87700  ? 385 GLY A CA    1 ? 
ATOM   3023 C C     . GLY A 1 391 ? -4.92530  -8.88678  27.64922  1.000 95.19893  ? 385 GLY A C     1 ? 
ATOM   3024 O O     . GLY A 1 391 ? -4.64250  -10.07384 27.47144  1.000 103.92220 ? 385 GLY A O     1 ? 
ATOM   3025 N N     . SER A 1 392 ? -3.98949  -7.93805  27.74529  1.000 93.10890  ? 386 SER A N     1 ? 
ATOM   3026 C CA    . SER A 1 392 ? -2.57488  -8.29479  27.73280  1.000 91.47791  ? 386 SER A CA    1 ? 
ATOM   3027 C C     . SER A 1 392 ? -2.19893  -9.11564  28.95836  1.000 91.79590  ? 386 SER A C     1 ? 
ATOM   3028 O O     . SER A 1 392 ? -1.24665  -9.90338  28.91170  1.000 87.52117  ? 386 SER A O     1 ? 
ATOM   3029 C CB    . SER A 1 392 ? -1.71399  -7.03347  27.65228  1.000 83.46344  ? 386 SER A CB    1 ? 
ATOM   3030 O OG    . SER A 1 392 ? -2.27810  -6.08424  26.76491  1.000 98.63206  ? 386 SER A OG    1 ? 
ATOM   3031 N N     . TYR A 1 393 ? -2.93427  -8.95045  30.05741  1.000 89.77008  ? 387 TYR A N     1 ? 
ATOM   3032 C CA    . TYR A 1 393 ? -2.68428  -9.71219  31.27377  1.000 87.74353  ? 387 TYR A CA    1 ? 
ATOM   3033 C C     . TYR A 1 393 ? -3.51492  -10.98675 31.32919  1.000 90.68496  ? 387 TYR A C     1 ? 
ATOM   3034 O O     . TYR A 1 393 ? -3.00086  -12.04248 31.71454  1.000 88.10074  ? 387 TYR A O     1 ? 
ATOM   3035 C CB    . TYR A 1 393 ? -2.96601  -8.84053  32.49857  1.000 91.90969  ? 387 TYR A CB    1 ? 
ATOM   3036 C CG    . TYR A 1 393 ? -1.85035  -7.87343  32.78378  1.000 90.77286  ? 387 TYR A CG    1 ? 
ATOM   3037 C CD1   . TYR A 1 393 ? -0.70367  -8.28429  33.44452  1.000 82.22804  ? 387 TYR A CD1   1 ? 
ATOM   3038 C CD2   . TYR A 1 393 ? -1.92318  -6.55878  32.34647  1.000 88.26180  ? 387 TYR A CD2   1 ? 
ATOM   3039 C CE1   . TYR A 1 393 ? 0.32242   -7.40378  33.69345  1.000 86.63187  ? 387 TYR A CE1   1 ? 
ATOM   3040 C CE2   . TYR A 1 393 ? -0.90101  -5.67218  32.58440  1.000 91.27028  ? 387 TYR A CE2   1 ? 
ATOM   3041 C CZ    . TYR A 1 393 ? 0.21969   -6.09689  33.25866  1.000 85.55347  ? 387 TYR A CZ    1 ? 
ATOM   3042 O OH    . TYR A 1 393 ? 1.24258   -5.20797  33.48958  1.000 81.18154  ? 387 TYR A OH    1 ? 
ATOM   3043 N N     . LYS A 1 394 ? -4.79198  -10.90851 30.94289  1.000 97.10114  ? 388 LYS A N     1 ? 
ATOM   3044 C CA    . LYS A 1 394 ? -5.62839  -12.10182 30.86942  1.000 98.18828  ? 388 LYS A CA    1 ? 
ATOM   3045 C C     . LYS A 1 394 ? -5.09185  -13.11960 29.87165  1.000 97.58875  ? 388 LYS A C     1 ? 
ATOM   3046 O O     . LYS A 1 394 ? -5.43755  -14.30279 29.96242  1.000 101.78609 ? 388 LYS A O     1 ? 
ATOM   3047 C CB    . LYS A 1 394 ? -7.06591  -11.72027 30.50047  1.000 95.98015  ? 388 LYS A CB    1 ? 
ATOM   3048 C CG    . LYS A 1 394 ? -7.79232  -10.91393 31.56537  1.000 96.65659  ? 388 LYS A CG    1 ? 
ATOM   3049 C CD    . LYS A 1 394 ? -9.26706  -10.74206 31.24679  1.000 95.58759  ? 388 LYS A CD    1 ? 
ATOM   3050 C CE    . LYS A 1 394 ? -9.53064  -9.38918  30.60712  1.000 103.64043 ? 388 LYS A CE    1 ? 
ATOM   3051 N NZ    . LYS A 1 394 ? -10.97879 -9.04420  30.58991  1.000 105.77079 ? 388 LYS A NZ    1 ? 
ATOM   3052 N N     . ARG A 1 395 ? -4.25594  -12.68878 28.92600  1.000 92.54517  ? 389 ARG A N     1 ? 
ATOM   3053 C CA    . ARG A 1 395 ? -3.66650  -13.59254 27.94792  1.000 90.41376  ? 389 ARG A CA    1 ? 
ATOM   3054 C C     . ARG A 1 395 ? -2.51982  -14.41752 28.51689  1.000 85.63877  ? 389 ARG A C     1 ? 
ATOM   3055 O O     . ARG A 1 395 ? -2.10822  -15.39386 27.88107  1.000 86.52310  ? 389 ARG A O     1 ? 
ATOM   3056 C CB    . ARG A 1 395 ? -3.17598  -12.80042 26.73336  1.000 93.20078  ? 389 ARG A CB    1 ? 
ATOM   3057 C CG    . ARG A 1 395 ? -3.48141  -13.45595 25.39845  1.000 98.92347  ? 389 ARG A CG    1 ? 
ATOM   3058 C CD    . ARG A 1 395 ? -3.22996  -12.49733 24.24567  1.000 99.88119  ? 389 ARG A CD    1 ? 
ATOM   3059 N NE    . ARG A 1 395 ? -1.94848  -12.74921 23.59781  1.000 106.99037 ? 389 ARG A NE    1 ? 
ATOM   3060 C CZ    . ARG A 1 395 ? -1.73674  -13.70454 22.70302  1.000 110.62274 ? 389 ARG A CZ    1 ? 
ATOM   3061 N NH1   . ARG A 1 395 ? -2.70529  -14.52083 22.32097  1.000 110.45593 ? 389 ARG A NH1   1 ? 
ATOM   3062 N NH2   . ARG A 1 395 ? -0.52278  -13.84423 22.17788  1.000 102.07546 ? 389 ARG A NH2   1 ? 
ATOM   3063 N N     . ILE A 1 396 ? -1.99483  -14.05231 29.68401  1.000 85.49195  ? 390 ILE A N     1 ? 
ATOM   3064 C CA    . ILE A 1 396 ? -0.93829  -14.80264 30.35162  1.000 87.16883  ? 390 ILE A CA    1 ? 
ATOM   3065 C C     . ILE A 1 396 ? -1.53429  -15.49741 31.56649  1.000 89.35831  ? 390 ILE A C     1 ? 
ATOM   3066 O O     . ILE A 1 396 ? -2.35322  -14.91597 32.28822  1.000 96.13196  ? 390 ILE A O     1 ? 
ATOM   3067 C CB    . ILE A 1 396 ? 0.23745   -13.89595 30.76543  1.000 86.87805  ? 390 ILE A CB    1 ? 
ATOM   3068 C CG1   . ILE A 1 396 ? 0.45254   -12.78800 29.73271  1.000 88.29605  ? 390 ILE A CG1   1 ? 
ATOM   3069 C CG2   . ILE A 1 396 ? 1.50470   -14.71959 30.94539  1.000 87.00048  ? 390 ILE A CG2   1 ? 
ATOM   3070 C CD1   . ILE A 1 396 ? 1.73194   -12.00358 29.93726  1.000 84.29394  ? 390 ILE A CD1   1 ? 
ATOM   3071 N N     . ASP A 1 397 ? -1.12239  -16.74276 31.79073  1.000 88.94371  ? 391 ASP A N     1 ? 
ATOM   3072 C CA    . ASP A 1 397 ? -1.59528  -17.52684 32.93053  1.000 99.64092  ? 391 ASP A CA    1 ? 
ATOM   3073 C C     . ASP A 1 397 ? -0.84382  -17.06234 34.17152  1.000 97.78861  ? 391 ASP A C     1 ? 
ATOM   3074 O O     . ASP A 1 397 ? 0.21081   -17.59148 34.52508  1.000 103.96693 ? 391 ASP A O     1 ? 
ATOM   3075 C CB    . ASP A 1 397 ? -1.39768  -19.01623 32.67817  1.000 96.74043  ? 391 ASP A CB    1 ? 
ATOM   3076 C CG    . ASP A 1 397 ? -2.20310  -19.88264 33.62744  1.000 99.30726  ? 391 ASP A CG    1 ? 
ATOM   3077 O OD1   . ASP A 1 397 ? -2.79138  -19.33696 34.58462  1.000 105.80996 ? 391 ASP A OD1   1 ? 
ATOM   3078 O OD2   . ASP A 1 397 ? -2.24579  -21.11298 33.41656  1.000 94.13401  ? 391 ASP A OD2   1 ? 
ATOM   3079 N N     . ILE A 1 398 ? -1.39642  -16.05803 34.84387  1.000 93.47749  ? 392 ILE A N     1 ? 
ATOM   3080 C CA    . ILE A 1 398 ? -0.79304  -15.47546 36.03629  1.000 94.60997  ? 392 ILE A CA    1 ? 
ATOM   3081 C C     . ILE A 1 398 ? -1.61944  -15.91263 37.23692  1.000 97.43718  ? 392 ILE A C     1 ? 
ATOM   3082 O O     . ILE A 1 398 ? -2.72736  -15.40793 37.45641  1.000 97.91540  ? 392 ILE A O     1 ? 
ATOM   3083 C CB    . ILE A 1 398 ? -0.71309  -13.94631 35.94966  1.000 95.17058  ? 392 ILE A CB    1 ? 
ATOM   3084 C CG1   . ILE A 1 398 ? 0.01197   -13.51821 34.67187  1.000 89.35444  ? 392 ILE A CG1   1 ? 
ATOM   3085 C CG2   . ILE A 1 398 ? -0.01684  -13.38947 37.17906  1.000 89.73271  ? 392 ILE A CG2   1 ? 
ATOM   3086 C CD1   . ILE A 1 398 ? 0.30454   -12.03400 34.60421  1.000 69.31197  ? 392 ILE A CD1   1 ? 
ATOM   3087 N N     . ARG A 1 399 ? -1.08152  -16.84324 38.02019  1.000 93.67609  ? 393 ARG A N     1 ? 
ATOM   3088 C CA    . ARG A 1 399 ? -1.73369  -17.34036 39.22510  1.000 99.80134  ? 393 ARG A CA    1 ? 
ATOM   3089 C C     . ARG A 1 399 ? -0.91371  -16.91617 40.43650  1.000 99.85839  ? 393 ARG A C     1 ? 
ATOM   3090 O O     . ARG A 1 399 ? 0.27569   -17.23934 40.52909  1.000 93.87876  ? 393 ARG A O     1 ? 
ATOM   3091 C CB    . ARG A 1 399 ? -1.88715  -18.86087 39.17883  1.000 103.66677 ? 393 ARG A CB    1 ? 
ATOM   3092 C CG    . ARG A 1 399 ? -2.98598  -19.34582 38.24477  1.000 103.47499 ? 393 ARG A CG    1 ? 
ATOM   3093 C CD    . ARG A 1 399 ? -3.03715  -20.86499 38.19074  1.000 105.52520 ? 393 ARG A CD    1 ? 
ATOM   3094 N NE    . ARG A 1 399 ? -3.15657  -21.36094 36.82469  1.000 112.07568 ? 393 ARG A NE    1 ? 
ATOM   3095 C CZ    . ARG A 1 399 ? -4.30824  -21.58805 36.20777  1.000 101.38622 ? 393 ARG A CZ    1 ? 
ATOM   3096 N NH1   . ARG A 1 399 ? -5.46787  -21.37436 36.80789  1.000 95.94101  ? 393 ARG A NH1   1 ? 
ATOM   3097 N NH2   . ARG A 1 399 ? -4.29617  -22.04144 34.95743  1.000 93.50848  ? 393 ARG A NH2   1 ? 
ATOM   3098 N N     . GLY A 1 400 ? -1.54863  -16.19478 41.35779  1.000 97.63321  ? 394 GLY A N     1 ? 
ATOM   3099 C CA    . GLY A 1 400 ? -0.86650  -15.70252 42.53862  1.000 96.02444  ? 394 GLY A CA    1 ? 
ATOM   3100 C C     . GLY A 1 400 ? -1.20287  -16.47513 43.79667  1.000 101.23456 ? 394 GLY A C     1 ? 
ATOM   3101 O O     . GLY A 1 400 ? -0.77944  -17.62358 43.95933  1.000 98.21424  ? 394 GLY A O     1 ? 
ATOM   3102 N N     . LYS A 1 401 ? -1.95864  -15.85429 44.69772  1.000 106.68805 ? 395 LYS A N     1 ? 
ATOM   3103 C CA    . LYS A 1 401 ? -2.36467  -16.51954 45.92566  1.000 103.94850 ? 395 LYS A CA    1 ? 
ATOM   3104 C C     . LYS A 1 401 ? -3.58695  -17.39424 45.67524  1.000 111.56132 ? 395 LYS A C     1 ? 
ATOM   3105 O O     . LYS A 1 401 ? -4.43969  -17.08150 44.83883  1.000 111.44081 ? 395 LYS A O     1 ? 
ATOM   3106 C CB    . LYS A 1 401 ? -2.65709  -15.49599 47.02267  1.000 92.38887  ? 395 LYS A CB    1 ? 
ATOM   3107 C CG    . LYS A 1 401 ? -1.45323  -15.18653 47.89935  1.000 99.05320  ? 395 LYS A CG    1 ? 
ATOM   3108 C CD    . LYS A 1 401 ? -1.59854  -13.84488 48.59569  1.000 96.03770  ? 395 LYS A CD    1 ? 
ATOM   3109 C CE    . LYS A 1 401 ? -2.58931  -13.92197 49.74319  1.000 81.09384  ? 395 LYS A CE    1 ? 
ATOM   3110 N NZ    . LYS A 1 401 ? -2.15503  -13.09178 50.90063  1.000 81.82875  ? 395 LYS A NZ    1 ? 
ATOM   3111 N N     . ASP A 1 402 ? -3.65500  -18.50936 46.40388  1.000 109.80039 ? 396 ASP A N     1 ? 
ATOM   3112 C CA    . ASP A 1 402 ? -4.64153  -19.56920 46.20627  1.000 111.87822 ? 396 ASP A CA    1 ? 
ATOM   3113 C C     . ASP A 1 402 ? -4.56988  -20.18486 44.81476  1.000 114.65191 ? 396 ASP A C     1 ? 
ATOM   3114 O O     . ASP A 1 402 ? -5.44459  -20.97868 44.44855  1.000 117.37237 ? 396 ASP A O     1 ? 
ATOM   3115 C CB    . ASP A 1 402 ? -6.07339  -19.07714 46.46914  1.000 119.42771 ? 396 ASP A CB    1 ? 
ATOM   3116 C CG    . ASP A 1 402 ? -6.36567  -18.87800 47.94162  1.000 126.42971 ? 396 ASP A CG    1 ? 
ATOM   3117 O OD1   . ASP A 1 402 ? -5.44594  -18.48253 48.68700  1.000 128.33667 ? 396 ASP A OD1   1 ? 
ATOM   3118 O OD2   . ASP A 1 402 ? -7.52229  -19.11460 48.35166  1.000 130.90073 ? 396 ASP A OD2   1 ? 
ATOM   3119 N N     . GLY A 1 403 ? -3.54660  -19.85202 44.03119  1.000 110.38119 ? 397 GLY A N     1 ? 
ATOM   3120 C CA    . GLY A 1 403 ? -3.55844  -20.20090 42.62691  1.000 111.14257 ? 397 GLY A CA    1 ? 
ATOM   3121 C C     . GLY A 1 403 ? -4.59613  -19.45430 41.82311  1.000 111.65229 ? 397 GLY A C     1 ? 
ATOM   3122 O O     . GLY A 1 403 ? -4.94366  -19.88693 40.72172  1.000 109.39628 ? 397 GLY A O     1 ? 
ATOM   3123 N N     . ILE A 1 404 ? -5.10833  -18.34067 42.34947  1.000 110.12252 ? 398 ILE A N     1 ? 
ATOM   3124 C CA    . ILE A 1 404 ? -6.14020  -17.58121 41.65477  1.000 117.57015 ? 398 ILE A CA    1 ? 
ATOM   3125 C C     . ILE A 1 404 ? -5.53287  -16.91943 40.42603  1.000 108.59747 ? 398 ILE A C     1 ? 
ATOM   3126 O O     . ILE A 1 404 ? -4.53045  -16.19826 40.51773  1.000 106.69580 ? 398 ILE A O     1 ? 
ATOM   3127 C CB    . ILE A 1 404 ? -6.77698  -16.54951 42.59899  1.000 112.04197 ? 398 ILE A CB    1 ? 
ATOM   3128 C CG1   . ILE A 1 404 ? -7.92501  -17.18818 43.38406  1.000 116.32239 ? 398 ILE A CG1   1 ? 
ATOM   3129 C CG2   . ILE A 1 404 ? -7.28329  -15.34083 41.82175  1.000 100.67568 ? 398 ILE A CG2   1 ? 
ATOM   3130 C CD1   . ILE A 1 404 ? -8.68896  -16.21466 44.25571  1.000 106.89619 ? 398 ILE A CD1   1 ? 
ATOM   3131 N N     . SER A 1 405 ? -6.13183  -17.17168 39.26659  1.000 108.80875 ? 399 SER A N     1 ? 
ATOM   3132 C CA    . SER A 1 405 ? -5.59668  -16.65552 38.01929  1.000 106.03521 ? 399 SER A CA    1 ? 
ATOM   3133 C C     . SER A 1 405 ? -6.02144  -15.20509 37.80601  1.000 101.81796 ? 399 SER A C     1 ? 
ATOM   3134 O O     . SER A 1 405 ? -7.02262  -14.73189 38.35144  1.000 103.96145 ? 399 SER A O     1 ? 
ATOM   3135 C CB    . SER A 1 405 ? -6.04981  -17.51788 36.84155  1.000 109.32150 ? 399 SER A CB    1 ? 
ATOM   3136 O OG    . SER A 1 405 ? -5.31854  -17.20125 35.67047  1.000 112.91561 ? 399 SER A OG    1 ? 
ATOM   3137 N N     . ILE A 1 406 ? -5.23549  -14.49922 36.98844  1.000 102.02453 ? 400 ILE A N     1 ? 
ATOM   3138 C CA    . ILE A 1 406 ? -5.48302  -13.08871 36.71486  1.000 102.99275 ? 400 ILE A CA    1 ? 
ATOM   3139 C C     . ILE A 1 406 ? -6.82118  -12.86913 36.02173  1.000 97.87960  ? 400 ILE A C     1 ? 
ATOM   3140 O O     . ILE A 1 406 ? -7.36895  -11.76230 36.07170  1.000 97.64727  ? 400 ILE A O     1 ? 
ATOM   3141 C CB    . ILE A 1 406 ? -4.31790  -12.51110 35.88093  1.000 93.79125  ? 400 ILE A CB    1 ? 
ATOM   3142 C CG1   . ILE A 1 406 ? -4.17868  -11.00275 36.10265  1.000 86.24100  ? 400 ILE A CG1   1 ? 
ATOM   3143 C CG2   . ILE A 1 406 ? -4.49542  -12.83781 34.40616  1.000 95.09836  ? 400 ILE A CG2   1 ? 
ATOM   3144 C CD1   . ILE A 1 406 ? -4.07601  -10.59904 37.54868  1.000 83.32101  ? 400 ILE A CD1   1 ? 
ATOM   3145 N N     . LYS A 1 407 ? -7.36999  -13.90258 35.37872  1.000 95.28511  ? 401 LYS A N     1 ? 
ATOM   3146 C CA    . LYS A 1 407 ? -8.65417  -13.76403 34.70308  1.000 99.50865  ? 401 LYS A CA    1 ? 
ATOM   3147 C C     . LYS A 1 407 ? -9.81677  -13.73220 35.68613  1.000 100.11028 ? 401 LYS A C     1 ? 
ATOM   3148 O O     . LYS A 1 407 ? -10.81766 -13.05296 35.43243  1.000 100.59060 ? 401 LYS A O     1 ? 
ATOM   3149 C CB    . LYS A 1 407 ? -8.84589  -14.90449 33.70103  1.000 101.07518 ? 401 LYS A CB    1 ? 
ATOM   3150 C CG    . LYS A 1 407 ? -8.37016  -16.25850 34.20475  1.000 104.55244 ? 401 LYS A CG    1 ? 
ATOM   3151 C CD    . LYS A 1 407 ? -7.97479  -17.17291 33.05592  1.000 100.72410 ? 401 LYS A CD    1 ? 
ATOM   3152 C CE    . LYS A 1 407 ? -6.65761  -16.73912 32.43396  1.000 95.88687  ? 401 LYS A CE    1 ? 
ATOM   3153 N NZ    . LYS A 1 407 ? -6.28930  -17.58223 31.26339  1.000 84.99053  ? 401 LYS A NZ    1 ? 
ATOM   3154 N N     . ASP A 1 408 ? -9.70588  -14.45176 36.80445  1.000 103.36138 ? 402 ASP A N     1 ? 
ATOM   3155 C CA    . ASP A 1 408 ? -10.79090 -14.48564 37.77885  1.000 105.41695 ? 402 ASP A CA    1 ? 
ATOM   3156 C C     . ASP A 1 408 ? -10.80262 -13.23771 38.65282  1.000 105.78437 ? 402 ASP A C     1 ? 
ATOM   3157 O O     . ASP A 1 408 ? -11.87089 -12.67726 38.92289  1.000 104.38870 ? 402 ASP A O     1 ? 
ATOM   3158 C CB    . ASP A 1 408 ? -10.67860 -15.73941 38.64706  1.000 113.50649 ? 402 ASP A CB    1 ? 
ATOM   3159 C CG    . ASP A 1 408 ? -11.41430 -16.92552 38.05632  1.000 116.04174 ? 402 ASP A CG    1 ? 
ATOM   3160 O OD1   . ASP A 1 408 ? -11.76205 -16.87542 36.85794  1.000 110.26139 ? 402 ASP A OD1   1 ? 
ATOM   3161 O OD2   . ASP A 1 408 ? -11.64518 -17.90880 38.79110  1.000 123.71324 ? 402 ASP A OD2   1 ? 
ATOM   3162 N N     . HIS A 1 409 ? -9.62789  -12.79146 39.10482  1.000 101.45958 ? 403 HIS A N     1 ? 
ATOM   3163 C CA    . HIS A 1 409 ? -9.56566  -11.61888 39.97048  1.000 101.02991 ? 403 HIS A CA    1 ? 
ATOM   3164 C C     . HIS A 1 409 ? -9.99475  -10.35506 39.23593  1.000 105.99987 ? 403 HIS A C     1 ? 
ATOM   3165 O O     . HIS A 1 409 ? -10.51146 -9.42229  39.86157  1.000 105.83435 ? 403 HIS A O     1 ? 
ATOM   3166 C CB    . HIS A 1 409 ? -8.15281  -11.46159 40.53481  1.000 97.18736  ? 403 HIS A CB    1 ? 
ATOM   3167 C CG    . HIS A 1 409 ? -8.00364  -10.31992 41.49236  1.000 102.77698 ? 403 HIS A CG    1 ? 
ATOM   3168 N ND1   . HIS A 1 409 ? -9.08070  -9.69974  42.08939  1.000 97.53863  ? 403 HIS A ND1   1 ? 
ATOM   3169 C CD2   . HIS A 1 409 ? -6.90098  -9.69270  41.96522  1.000 103.03933 ? 403 HIS A CD2   1 ? 
ATOM   3170 C CE1   . HIS A 1 409 ? -8.64798  -8.73553  42.88157  1.000 104.68865 ? 403 HIS A CE1   1 ? 
ATOM   3171 N NE2   . HIS A 1 409 ? -7.32854  -8.70987  42.82424  1.000 101.17438 ? 403 HIS A NE2   1 ? 
ATOM   3172 N N     . TRP A 1 410 ? -9.79549  -10.30462 37.91836  1.000 103.12675 ? 404 TRP A N     1 ? 
ATOM   3173 C CA    . TRP A 1 410 ? -10.22573 -9.17611  37.10351  1.000 102.61432 ? 404 TRP A CA    1 ? 
ATOM   3174 C C     . TRP A 1 410 ? -11.42588 -9.52206  36.23013  1.000 108.80303 ? 404 TRP A C     1 ? 
ATOM   3175 O O     . TRP A 1 410 ? -11.67597 -8.84037  35.23065  1.000 110.30966 ? 404 TRP A O     1 ? 
ATOM   3176 C CB    . TRP A 1 410 ? -9.07442  -8.67340  36.23284  1.000 102.09248 ? 404 TRP A CB    1 ? 
ATOM   3177 C CG    . TRP A 1 410 ? -8.16318  -7.71541  36.92926  1.000 101.68669 ? 404 TRP A CG    1 ? 
ATOM   3178 C CD1   . TRP A 1 410 ? -8.38946  -7.08192  38.11562  1.000 99.65286  ? 404 TRP A CD1   1 ? 
ATOM   3179 C CD2   . TRP A 1 410 ? -6.88176  -7.26751  36.47265  1.000 100.08959 ? 404 TRP A CD2   1 ? 
ATOM   3180 N NE1   . TRP A 1 410 ? -7.32132  -6.27739  38.43239  1.000 96.80269  ? 404 TRP A NE1   1 ? 
ATOM   3181 C CE2   . TRP A 1 410 ? -6.38435  -6.37065  37.43711  1.000 92.91592  ? 404 TRP A CE2   1 ? 
ATOM   3182 C CE3   . TRP A 1 410 ? -6.10625  -7.53998  35.34261  1.000 104.06419 ? 404 TRP A CE3   1 ? 
ATOM   3183 C CZ2   . TRP A 1 410 ? -5.14586  -5.74588  37.30632  1.000 99.12389  ? 404 TRP A CZ2   1 ? 
ATOM   3184 C CZ3   . TRP A 1 410 ? -4.87767  -6.92025  35.21458  1.000 105.26716 ? 404 TRP A CZ3   1 ? 
ATOM   3185 C CH2   . TRP A 1 410 ? -4.40952  -6.03330  36.19053  1.000 104.93178 ? 404 TRP A CH2   1 ? 
ATOM   3186 N N     . LYS A 1 411 ? -12.16808 -10.57572 36.58403  1.000 106.92379 ? 405 LYS A N     1 ? 
ATOM   3187 C CA    . LYS A 1 411 ? -13.33127 -10.96445 35.79297  1.000 111.81521 ? 405 LYS A CA    1 ? 
ATOM   3188 C C     . LYS A 1 411 ? -14.34629 -9.83245  35.70121  1.000 119.49458 ? 405 LYS A C     1 ? 
ATOM   3189 O O     . LYS A 1 411 ? -15.00904 -9.67403  34.66921  1.000 117.34743 ? 405 LYS A O     1 ? 
ATOM   3190 C CB    . LYS A 1 411 ? -13.97011 -12.22144 36.38898  1.000 110.17386 ? 405 LYS A CB    1 ? 
ATOM   3191 C CG    . LYS A 1 411 ? -15.30754 -12.60785 35.77353  1.000 111.15528 ? 405 LYS A CG    1 ? 
ATOM   3192 C CD    . LYS A 1 411 ? -16.05365 -13.61606 36.63719  1.000 115.87144 ? 405 LYS A CD    1 ? 
ATOM   3193 C CE    . LYS A 1 411 ? -16.04789 -13.21370 38.10370  1.000 108.27173 ? 405 LYS A CE    1 ? 
ATOM   3194 N NZ    . LYS A 1 411 ? -16.27994 -14.37989 39.00007  1.000 109.23690 ? 405 LYS A NZ    1 ? 
ATOM   3195 N N     . ASP A 1 412 ? -14.46960 -9.03026  36.75386  1.000 120.21038 ? 406 ASP A N     1 ? 
ATOM   3196 C CA    . ASP A 1 412 ? -15.33257 -7.85452  36.75564  1.000 112.83555 ? 406 ASP A CA    1 ? 
ATOM   3197 C C     . ASP A 1 412 ? -14.46834 -6.59841  36.68892  1.000 106.84516 ? 406 ASP A C     1 ? 
ATOM   3198 O O     . ASP A 1 412 ? -14.39433 -5.80800  37.63241  1.000 108.34489 ? 406 ASP A O     1 ? 
ATOM   3199 C CB    . ASP A 1 412 ? -16.23652 -7.85487  37.99594  1.000 115.13772 ? 406 ASP A CB    1 ? 
ATOM   3200 C CG    . ASP A 1 412 ? -17.16128 -9.05627  38.04503  1.000 115.16673 ? 406 ASP A CG    1 ? 
ATOM   3201 O OD1   . ASP A 1 412 ? -16.80425 -10.11061 37.47955  1.000 121.84995 ? 406 ASP A OD1   1 ? 
ATOM   3202 O OD2   . ASP A 1 412 ? -18.24888 -8.94492  38.64871  1.000 105.51331 ? 406 ASP A OD2   1 ? 
ATOM   3203 N N     . GLY A 1 413 ? -13.80027 -6.42263  35.55124  1.000 103.60730 ? 407 GLY A N     1 ? 
ATOM   3204 C CA    . GLY A 1 413 ? -12.99962 -5.24640  35.30866  1.000 98.16527  ? 407 GLY A CA    1 ? 
ATOM   3205 C C     . GLY A 1 413 ? -11.67256 -5.26540  36.04005  1.000 102.88632 ? 407 GLY A C     1 ? 
ATOM   3206 O O     . GLY A 1 413 ? -11.48605 -5.98636  37.02539  1.000 105.70929 ? 407 GLY A O     1 ? 
ATOM   3207 N N     . PRO A 1 414 ? -10.71946 -4.47142  35.56292  1.000 102.01867 ? 408 PRO A N     1 ? 
ATOM   3208 C CA    . PRO A 1 414 ? -9.41370  -4.39956  36.22210  1.000 99.97111  ? 408 PRO A CA    1 ? 
ATOM   3209 C C     . PRO A 1 414 ? -9.40728  -3.41086  37.38009  1.000 100.61709 ? 408 PRO A C     1 ? 
ATOM   3210 O O     . PRO A 1 414 ? -10.23519 -2.50285  37.47351  1.000 104.48849 ? 408 PRO A O     1 ? 
ATOM   3211 C CB    . PRO A 1 414 ? -8.48282  -3.93320  35.09850  1.000 98.15894  ? 408 PRO A CB    1 ? 
ATOM   3212 C CG    . PRO A 1 414 ? -9.36471  -3.10164  34.22934  1.000 102.30809 ? 408 PRO A CG    1 ? 
ATOM   3213 C CD    . PRO A 1 414 ? -10.73773 -3.73071  34.28882  1.000 109.00742 ? 408 PRO A CD    1 ? 
ATOM   3214 N N     . ASN A 1 415 ? -8.44034  -3.61344  38.27249  1.000 99.07287  ? 409 ASN A N     1 ? 
ATOM   3215 C CA    . ASN A 1 415 ? -8.21685  -2.73574  39.41333  1.000 97.52093  ? 409 ASN A CA    1 ? 
ATOM   3216 C C     . ASN A 1 415 ? -6.80116  -2.96422  39.92141  1.000 101.88054 ? 409 ASN A C     1 ? 
ATOM   3217 O O     . ASN A 1 415 ? -6.18077  -3.99129  39.63397  1.000 96.21726  ? 409 ASN A O     1 ? 
ATOM   3218 C CB    . ASN A 1 415 ? -9.24883  -2.97001  40.52566  1.000 95.47294  ? 409 ASN A CB    1 ? 
ATOM   3219 C CG    . ASN A 1 415 ? -9.34886  -4.42987  40.94731  1.000 103.20071 ? 409 ASN A CG    1 ? 
ATOM   3220 O OD1   . ASN A 1 415 ? -8.40324  -5.20506  40.80476  1.000 102.40725 ? 409 ASN A OD1   1 ? 
ATOM   3221 N ND2   . ASN A 1 415 ? -10.50713 -4.80767  41.47573  1.000 108.48039 ? 409 ASN A ND2   1 ? 
ATOM   3222 N N     . SER A 1 416 ? -6.29893  -1.99820  40.68287  1.000 95.52830  ? 410 SER A N     1 ? 
ATOM   3223 C CA    . SER A 1 416 ? -4.92758  -2.05312  41.18050  1.000 89.93462  ? 410 SER A CA    1 ? 
ATOM   3224 C C     . SER A 1 416 ? -4.74844  -0.96956  42.23763  1.000 91.05079  ? 410 SER A C     1 ? 
ATOM   3225 O O     . SER A 1 416 ? -5.66560  -0.19439  42.52697  1.000 90.31002  ? 410 SER A O     1 ? 
ATOM   3226 C CB    . SER A 1 416 ? -3.91929  -1.89111  40.04070  1.000 80.87691  ? 410 SER A CB    1 ? 
ATOM   3227 O OG    . SER A 1 416 ? -4.17461  -0.70648  39.30822  1.000 92.71076  ? 410 SER A OG    1 ? 
ATOM   3228 N N     . TYR A 1 417 ? -3.55151  -0.93194  42.81876  1.000 87.95391  ? 411 TYR A N     1 ? 
ATOM   3229 C CA    . TYR A 1 417 ? -3.14560  0.09802   43.76693  1.000 93.99334  ? 411 TYR A CA    1 ? 
ATOM   3230 C C     . TYR A 1 417 ? -2.07332  0.95067   43.10356  1.000 92.74759  ? 411 TYR A C     1 ? 
ATOM   3231 O O     . TYR A 1 417 ? -1.02117  0.43264   42.71250  1.000 85.28247  ? 411 TYR A O     1 ? 
ATOM   3232 C CB    . TYR A 1 417 ? -2.62388  -0.52291  45.06345  1.000 95.36578  ? 411 TYR A CB    1 ? 
ATOM   3233 C CG    . TYR A 1 417 ? -2.40744  0.46501   46.19033  1.000 94.44186  ? 411 TYR A CG    1 ? 
ATOM   3234 C CD1   . TYR A 1 417 ? -3.15962  1.62915   46.27826  1.000 97.07662  ? 411 TYR A CD1   1 ? 
ATOM   3235 C CD2   . TYR A 1 417 ? -1.45392  0.22715   47.17152  1.000 92.76577  ? 411 TYR A CD2   1 ? 
ATOM   3236 C CE1   . TYR A 1 417 ? -2.96244  2.53051   47.30924  1.000 95.28865  ? 411 TYR A CE1   1 ? 
ATOM   3237 C CE2   . TYR A 1 417 ? -1.24910  1.12100   48.20345  1.000 92.50177  ? 411 TYR A CE2   1 ? 
ATOM   3238 C CZ    . TYR A 1 417 ? -2.00566  2.27004   48.26855  1.000 94.17052  ? 411 TYR A CZ    1 ? 
ATOM   3239 O OH    . TYR A 1 417 ? -1.80321  3.16027   49.29761  1.000 99.87309  ? 411 TYR A OH    1 ? 
ATOM   3240 N N     . LEU A 1 418 ? -2.34863  2.24911   42.96610  1.000 89.98818  ? 412 LEU A N     1 ? 
ATOM   3241 C CA    . LEU A 1 418 ? -1.48904  3.19205   42.24951  1.000 89.27254  ? 412 LEU A CA    1 ? 
ATOM   3242 C C     . LEU A 1 418 ? -1.25823  2.77787   40.79892  1.000 84.14934  ? 412 LEU A C     1 ? 
ATOM   3243 O O     . LEU A 1 418 ? -0.34074  3.28352   40.14397  1.000 79.06236  ? 412 LEU A O     1 ? 
ATOM   3244 C CB    . LEU A 1 418 ? -0.14170  3.38339   42.95920  1.000 91.39804  ? 412 LEU A CB    1 ? 
ATOM   3245 C CG    . LEU A 1 418 ? -0.11504  3.42208   44.48863  1.000 84.50244  ? 412 LEU A CG    1 ? 
ATOM   3246 C CD1   . LEU A 1 418 ? 1.31048   3.59926   44.98492  1.000 82.01753  ? 412 LEU A CD1   1 ? 
ATOM   3247 C CD2   . LEU A 1 418 ? -1.00727  4.53348   45.01759  1.000 88.79716  ? 412 LEU A CD2   1 ? 
ATOM   3248 N N     . GLY A 1 419 ? -2.07897  1.86620   40.28131  1.000 80.52351  ? 413 GLY A N     1 ? 
ATOM   3249 C CA    . GLY A 1 419 ? -1.91154  1.39247   38.92361  1.000 83.11315  ? 413 GLY A CA    1 ? 
ATOM   3250 C C     . GLY A 1 419 ? -0.70912  0.50732   38.69760  1.000 81.02805  ? 413 GLY A C     1 ? 
ATOM   3251 O O     . GLY A 1 419 ? -0.28462  0.34184   37.55126  1.000 73.61181  ? 413 GLY A O     1 ? 
ATOM   3252 N N     . MET A 1 420 ? -0.15010  -0.08189  39.75549  1.000 84.86928  ? 414 MET A N     1 ? 
ATOM   3253 C CA    . MET A 1 420 ? 1.10766   -0.80766  39.62307  1.000 82.60736  ? 414 MET A CA    1 ? 
ATOM   3254 C C     . MET A 1 420 ? 1.07256   -2.19054  40.26617  1.000 78.44570  ? 414 MET A C     1 ? 
ATOM   3255 O O     . MET A 1 420 ? 1.79878   -3.09118  39.83387  1.000 76.38990  ? 414 MET A O     1 ? 
ATOM   3256 C CB    . MET A 1 420 ? 2.25093   0.01649   40.22192  1.000 79.72598  ? 414 MET A CB    1 ? 
ATOM   3257 C CG    . MET A 1 420 ? 2.53798   1.31171   39.47539  1.000 80.84146  ? 414 MET A CG    1 ? 
ATOM   3258 S SD    . MET A 1 420 ? 3.95187   2.21211   40.13836  1.000 92.36594  ? 414 MET A SD    1 ? 
ATOM   3259 C CE    . MET A 1 420 ? 3.15137   3.23765   41.36887  1.000 78.67262  ? 414 MET A CE    1 ? 
ATOM   3260 N N     . MET A 1 421 ? 0.25227   -2.37759  41.29961  1.000 78.59283  ? 415 MET A N     1 ? 
ATOM   3261 C CA    . MET A 1 421 ? 0.21190   -3.63984  42.02733  1.000 80.01901  ? 415 MET A CA    1 ? 
ATOM   3262 C C     . MET A 1 421 ? -1.22516  -4.10097  42.22299  1.000 84.29291  ? 415 MET A C     1 ? 
ATOM   3263 O O     . MET A 1 421 ? -2.13115  -3.28369  42.41179  1.000 84.85615  ? 415 MET A O     1 ? 
ATOM   3264 C CB    . MET A 1 421 ? 0.91103   -3.52445  43.39277  1.000 76.16830  ? 415 MET A CB    1 ? 
ATOM   3265 C CG    . MET A 1 421 ? 2.11424   -2.59115  43.40989  1.000 92.04413  ? 415 MET A CG    1 ? 
ATOM   3266 S SD    . MET A 1 421 ? 2.67853   -2.19699  45.07518  1.000 98.44148  ? 415 MET A SD    1 ? 
ATOM   3267 C CE    . MET A 1 421 ? 1.24409   -1.34149  45.71286  1.000 89.46550  ? 415 MET A CE    1 ? 
ATOM   3268 N N     . VAL A 1 422 ? -1.42312  -5.41775  42.18031  1.000 84.05116  ? 416 VAL A N     1 ? 
ATOM   3269 C CA    . VAL A 1 422 ? -2.72685  -6.03263  42.39599  1.000 88.48174  ? 416 VAL A CA    1 ? 
ATOM   3270 C C     . VAL A 1 422 ? -2.68428  -6.82372  43.69503  1.000 100.29886 ? 416 VAL A C     1 ? 
ATOM   3271 O O     . VAL A 1 422 ? -1.64642  -7.37629  44.07829  1.000 106.57071 ? 416 VAL A O     1 ? 
ATOM   3272 C CB    . VAL A 1 422 ? -3.14139  -6.95240  41.22602  1.000 91.43997  ? 416 VAL A CB    1 ? 
ATOM   3273 C CG1   . VAL A 1 422 ? -4.64237  -7.22137  41.26250  1.000 92.33188  ? 416 VAL A CG1   1 ? 
ATOM   3274 C CG2   . VAL A 1 422 ? -2.72157  -6.35966  39.88982  1.000 85.63454  ? 416 VAL A CG2   1 ? 
ATOM   3275 N N     . SER A 1 423 ? -3.82503  -6.87672  44.37578  1.000 101.08200 ? 417 SER A N     1 ? 
ATOM   3276 C CA    . SER A 1 423 ? -3.96123  -7.73746  45.53874  1.000 105.35793 ? 417 SER A CA    1 ? 
ATOM   3277 C C     . SER A 1 423 ? -4.11327  -9.18677  45.09567  1.000 106.70928 ? 417 SER A C     1 ? 
ATOM   3278 O O     . SER A 1 423 ? -4.56438  -9.47206  43.98222  1.000 110.04370 ? 417 SER A O     1 ? 
ATOM   3279 C CB    . SER A 1 423 ? -5.15745  -7.31503  46.39099  1.000 110.82316 ? 417 SER A CB    1 ? 
ATOM   3280 O OG    . SER A 1 423 ? -4.82003  -7.30737  47.76717  1.000 114.07394 ? 417 SER A OG    1 ? 
ATOM   3281 N N     . ASN A 1 424 ? -3.72624  -10.10244 45.98530  1.000 111.30814 ? 418 ASN A N     1 ? 
ATOM   3282 C CA    . ASN A 1 424 ? -3.59918  -11.54246 45.75405  1.000 107.74075 ? 418 ASN A CA    1 ? 
ATOM   3283 C C     . ASN A 1 424 ? -2.42931  -11.89997 44.84104  1.000 104.21118 ? 418 ASN A C     1 ? 
ATOM   3284 O O     . ASN A 1 424 ? -2.16717  -13.08266 44.63744  1.000 100.53474 ? 418 ASN A O     1 ? 
ATOM   3285 C CB    . ASN A 1 424 ? -4.87629  -12.17364 45.17459  1.000 108.34618 ? 418 ASN A CB    1 ? 
ATOM   3286 C CG    . ASN A 1 424 ? -6.11156  -11.84100 45.97696  1.000 114.24858 ? 418 ASN A CG    1 ? 
ATOM   3287 O OD1   . ASN A 1 424 ? -6.03753  -11.58574 47.17670  1.000 110.90773 ? 418 ASN A OD1   1 ? 
ATOM   3288 N ND2   . ASN A 1 424 ? -7.26331  -11.84877 45.31505  1.000 108.35699 ? 418 ASN A ND2   1 ? 
ATOM   3289 N N     . PHE A 1 425 ? -1.71781  -10.91813 44.28965  1.000 100.57079 ? 419 PHE A N     1 ? 
ATOM   3290 C CA    . PHE A 1 425 ? -0.59159  -11.13833 43.38798  1.000 97.01219  ? 419 PHE A CA    1 ? 
ATOM   3291 C C     . PHE A 1 425 ? 0.61818   -10.40710 43.94526  1.000 94.77778  ? 419 PHE A C     1 ? 
ATOM   3292 O O     . PHE A 1 425 ? 0.95934   -9.29433  43.50170  1.000 94.16074  ? 419 PHE A O     1 ? 
ATOM   3293 C CB    . PHE A 1 425 ? -0.91474  -10.67565 41.97975  1.000 92.56626  ? 419 PHE A CB    1 ? 
ATOM   3294 C CG    . PHE A 1 425 ? -2.05729  -11.44540 41.34953  1.000 90.72904  ? 419 PHE A CG    1 ? 
ATOM   3295 C CD1   . PHE A 1 425 ? -3.37646  -11.07436 41.55803  1.000 90.95837  ? 419 PHE A CD1   1 ? 
ATOM   3296 C CD2   . PHE A 1 425 ? -1.80699  -12.54252 40.54548  1.000 91.49028  ? 419 PHE A CD2   1 ? 
ATOM   3297 C CE1   . PHE A 1 425 ? -4.41327  -11.77398 40.98685  1.000 92.74166  ? 419 PHE A CE1   1 ? 
ATOM   3298 C CE2   . PHE A 1 425 ? -2.83294  -13.25321 39.96541  1.000 95.65767  ? 419 PHE A CE2   1 ? 
ATOM   3299 C CZ    . PHE A 1 425 ? -4.14863  -12.87071 40.18659  1.000 96.27586  ? 419 PHE A CZ    1 ? 
ATOM   3300 N N     . PRO A 1 426 ? 1.29393   -10.99438 44.92824  1.000 97.85141  ? 420 PRO A N     1 ? 
ATOM   3301 C CA    . PRO A 1 426 ? 2.46559   -10.32647 45.51346  1.000 93.91434  ? 420 PRO A CA    1 ? 
ATOM   3302 C C     . PRO A 1 426 ? 3.69374   -10.42138 44.60997  1.000 87.76353  ? 420 PRO A C     1 ? 
ATOM   3303 O O     . PRO A 1 426 ? 3.76136   -11.21854 43.66644  1.000 83.86585  ? 420 PRO A O     1 ? 
ATOM   3304 C CB    . PRO A 1 426 ? 2.71989   -11.06576 46.84303  1.000 95.51029  ? 420 PRO A CB    1 ? 
ATOM   3305 C CG    . PRO A 1 426 ? 1.71574   -12.11632 46.93635  1.000 100.52528 ? 420 PRO A CG    1 ? 
ATOM   3306 C CD    . PRO A 1 426 ? 0.84315   -12.15247 45.73700  1.000 98.52641  ? 420 PRO A CD    1 ? 
ATOM   3307 N N     . ASN A 1 427 ? 4.68638   -9.58550  44.93982  1.000 86.12857  ? 421 ASN A N     1 ? 
ATOM   3308 C CA    . ASN A 1 427 ? 5.91589   -9.41900  44.16363  1.000 85.60291  ? 421 ASN A CA    1 ? 
ATOM   3309 C C     . ASN A 1 427 ? 5.64515   -9.03334  42.71284  1.000 83.51267  ? 421 ASN A C     1 ? 
ATOM   3310 O O     . ASN A 1 427 ? 6.50695   -9.21551  41.84966  1.000 79.82514  ? 421 ASN A O     1 ? 
ATOM   3311 C CB    . ASN A 1 427 ? 6.79229   -10.67700 44.22913  1.000 87.80427  ? 421 ASN A CB    1 ? 
ATOM   3312 C CG    . ASN A 1 427 ? 7.56847   -10.77832 45.52389  1.000 89.50301  ? 421 ASN A CG    1 ? 
ATOM   3313 O OD1   . ASN A 1 427 ? 7.28381   -10.07079 46.48758  1.000 85.60918  ? 421 ASN A OD1   1 ? 
ATOM   3314 N ND2   . ASN A 1 427 ? 8.55586   -11.66561 45.55316  1.000 87.44819  ? 421 ASN A ND2   1 ? 
ATOM   3315 N N     . MET A 1 428 ? 4.46385   -8.49118  42.43939  1.000 84.36540  ? 422 MET A N     1 ? 
ATOM   3316 C CA    . MET A 1 428 ? 4.05642   -8.10262  41.09863  1.000 83.06762  ? 422 MET A CA    1 ? 
ATOM   3317 C C     . MET A 1 428 ? 4.04614   -6.58585  40.99151  1.000 84.76993  ? 422 MET A C     1 ? 
ATOM   3318 O O     . MET A 1 428 ? 3.46407   -5.90506  41.84089  1.000 84.91098  ? 422 MET A O     1 ? 
ATOM   3319 C CB    . MET A 1 428 ? 2.67474   -8.66540  40.76255  1.000 87.67562  ? 422 MET A CB    1 ? 
ATOM   3320 C CG    . MET A 1 428 ? 2.14993   -8.22359  39.41006  1.000 103.31828 ? 422 MET A CG    1 ? 
ATOM   3321 S SD    . MET A 1 428 ? 2.39193   -9.47514  38.13930  1.000 106.92617 ? 422 MET A SD    1 ? 
ATOM   3322 C CE    . MET A 1 428 ? 0.69822   -9.97299  37.85204  1.000 84.91585  ? 422 MET A CE    1 ? 
ATOM   3323 N N     . PHE A 1 429 ? 4.68158   -6.06225  39.94574  1.000 80.55274  ? 423 PHE A N     1 ? 
ATOM   3324 C CA    . PHE A 1 429 ? 4.75010   -4.62426  39.72744  1.000 80.67072  ? 423 PHE A CA    1 ? 
ATOM   3325 C C     . PHE A 1 429 ? 4.47784   -4.33715  38.26144  1.000 76.87718  ? 423 PHE A C     1 ? 
ATOM   3326 O O     . PHE A 1 429 ? 5.13007   -4.90803  37.38278  1.000 73.93506  ? 423 PHE A O     1 ? 
ATOM   3327 C CB    . PHE A 1 429 ? 6.11337   -4.07014  40.14928  1.000 76.25312  ? 423 PHE A CB    1 ? 
ATOM   3328 C CG    . PHE A 1 429 ? 6.40029   -4.24004  41.61195  1.000 78.13585  ? 423 PHE A CG    1 ? 
ATOM   3329 C CD1   . PHE A 1 429 ? 5.60716   -3.61645  42.56081  1.000 79.15787  ? 423 PHE A CD1   1 ? 
ATOM   3330 C CD2   . PHE A 1 429 ? 7.44797   -5.03749  42.03973  1.000 74.90500  ? 423 PHE A CD2   1 ? 
ATOM   3331 C CE1   . PHE A 1 429 ? 5.86035   -3.77540  43.90911  1.000 79.62901  ? 423 PHE A CE1   1 ? 
ATOM   3332 C CE2   . PHE A 1 429 ? 7.70691   -5.20033  43.38712  1.000 76.17541  ? 423 PHE A CE2   1 ? 
ATOM   3333 C CZ    . PHE A 1 429 ? 6.91199   -4.56821  44.32307  1.000 75.69436  ? 423 PHE A CZ    1 ? 
ATOM   3334 N N     . MET A 1 430 ? 3.51869   -3.45530  38.00298  1.000 77.95901  ? 424 MET A N     1 ? 
ATOM   3335 C CA    . MET A 1 430 ? 3.00696   -3.22644  36.66108  1.000 73.63314  ? 424 MET A CA    1 ? 
ATOM   3336 C C     . MET A 1 430 ? 3.51844   -1.89264  36.13897  1.000 79.15564  ? 424 MET A C     1 ? 
ATOM   3337 O O     . MET A 1 430 ? 3.44540   -0.87729  36.83888  1.000 80.34812  ? 424 MET A O     1 ? 
ATOM   3338 C CB    . MET A 1 430 ? 1.47843   -3.23814  36.65684  1.000 72.06253  ? 424 MET A CB    1 ? 
ATOM   3339 C CG    . MET A 1 430 ? 0.87635   -4.61173  36.43938  1.000 73.86649  ? 424 MET A CG    1 ? 
ATOM   3340 S SD    . MET A 1 430 ? -0.92034  -4.54761  36.38758  1.000 93.21921  ? 424 MET A SD    1 ? 
ATOM   3341 C CE    . MET A 1 430 ? -1.27023  -3.75640  37.95313  1.000 79.34515  ? 424 MET A CE    1 ? 
ATOM   3342 N N     . VAL A 1 431 ? 4.03205   -1.90045  34.91374  1.000 80.72194  ? 425 VAL A N     1 ? 
ATOM   3343 C CA    . VAL A 1 431 ? 4.43243   -0.68684  34.21330  1.000 72.73844  ? 425 VAL A CA    1 ? 
ATOM   3344 C C     . VAL A 1 431 ? 3.37400   -0.37909  33.16543  1.000 79.81063  ? 425 VAL A C     1 ? 
ATOM   3345 O O     . VAL A 1 431 ? 3.03313   -1.24245  32.34561  1.000 79.48485  ? 425 VAL A O     1 ? 
ATOM   3346 C CB    . VAL A 1 431 ? 5.82099   -0.84187  33.57081  1.000 63.99730  ? 425 VAL A CB    1 ? 
ATOM   3347 C CG1   . VAL A 1 431 ? 6.25653   0.46649   32.92959  1.000 62.96349  ? 425 VAL A CG1   1 ? 
ATOM   3348 C CG2   . VAL A 1 431 ? 6.83687   -1.29398  34.61094  1.000 70.54935  ? 425 VAL A CG2   1 ? 
ATOM   3349 N N     . PHE A 1 432 ? 2.84958   0.84790   33.19597  1.000 79.09089  ? 426 PHE A N     1 ? 
ATOM   3350 C CA    . PHE A 1 432 ? 1.74665   1.26183   32.32797  1.000 82.00665  ? 426 PHE A CA    1 ? 
ATOM   3351 C C     . PHE A 1 432 ? 0.52807   0.35734   32.49587  1.000 81.09164  ? 426 PHE A C     1 ? 
ATOM   3352 O O     . PHE A 1 432 ? -0.19717  0.08917   31.53444  1.000 93.81617  ? 426 PHE A O     1 ? 
ATOM   3353 C CB    . PHE A 1 432 ? 2.17768   1.31225   30.85814  1.000 77.53957  ? 426 PHE A CB    1 ? 
ATOM   3354 C CG    . PHE A 1 432 ? 1.60187   2.47229   30.09770  1.000 73.84882  ? 426 PHE A CG    1 ? 
ATOM   3355 C CD1   . PHE A 1 432 ? 1.01818   3.53524   30.76673  1.000 72.84409  ? 426 PHE A CD1   1 ? 
ATOM   3356 C CD2   . PHE A 1 432 ? 1.63534   2.49584   28.71349  1.000 82.84404  ? 426 PHE A CD2   1 ? 
ATOM   3357 C CE1   . PHE A 1 432 ? 0.48463   4.60307   30.06984  1.000 71.84773  ? 426 PHE A CE1   1 ? 
ATOM   3358 C CE2   . PHE A 1 432 ? 1.10262   3.56051   28.01075  1.000 81.00488  ? 426 PHE A CE2   1 ? 
ATOM   3359 C CZ    . PHE A 1 432 ? 0.52578   4.61465   28.69002  1.000 75.03180  ? 426 PHE A CZ    1 ? 
ATOM   3360 N N     . GLY A 1 433 ? 0.29272   -0.11921  33.72297  1.000 74.21489  ? 427 GLY A N     1 ? 
ATOM   3361 C CA    . GLY A 1 433 ? -0.81600  -0.98967  33.98695  1.000 72.27363  ? 427 GLY A CA    1 ? 
ATOM   3362 C C     . GLY A 1 433 ? -2.13024  -0.23625  34.04172  1.000 84.51535  ? 427 GLY A C     1 ? 
ATOM   3363 O O     . GLY A 1 433 ? -2.19787  0.97410   33.77703  1.000 85.19388  ? 427 GLY A O     1 ? 
ATOM   3364 N N     . PRO A 1 434 ? -3.20080  -0.94551  34.38929  1.000 93.65756  ? 428 PRO A N     1 ? 
ATOM   3365 C CA    . PRO A 1 434 ? -4.51943  -0.31635  34.45701  1.000 93.11354  ? 428 PRO A CA    1 ? 
ATOM   3366 C C     . PRO A 1 434 ? -4.62181  0.63725   35.63803  1.000 96.78526  ? 428 PRO A C     1 ? 
ATOM   3367 O O     . PRO A 1 434 ? -3.82347  0.59865   36.57660  1.000 91.68447  ? 428 PRO A O     1 ? 
ATOM   3368 C CB    . PRO A 1 434 ? -5.47533  -1.50135  34.61530  1.000 94.58204  ? 428 PRO A CB    1 ? 
ATOM   3369 C CG    . PRO A 1 434 ? -4.65160  -2.54500  35.28846  1.000 101.50163 ? 428 PRO A CG    1 ? 
ATOM   3370 C CD    . PRO A 1 434 ? -3.24849  -2.37270  34.76268  1.000 97.07630  ? 428 PRO A CD    1 ? 
ATOM   3371 N N     . ASN A 1 435 ? -5.63325  1.50563   35.56959  1.000 98.76673  ? 429 ASN A N     1 ? 
ATOM   3372 C CA    . ASN A 1 435 ? -5.88110  2.52094   36.59574  1.000 95.03846  ? 429 ASN A CA    1 ? 
ATOM   3373 C C     . ASN A 1 435 ? -4.67762  3.44526   36.76547  1.000 95.19832  ? 429 ASN A C     1 ? 
ATOM   3374 O O     . ASN A 1 435 ? -4.36438  3.89438   37.87001  1.000 95.29753  ? 429 ASN A O     1 ? 
ATOM   3375 C CB    . ASN A 1 435 ? -6.27226  1.88011   37.92935  1.000 101.43573 ? 429 ASN A CB    1 ? 
ATOM   3376 C CG    . ASN A 1 435 ? -7.76807  1.68395   38.06242  1.000 111.10477 ? 429 ASN A CG    1 ? 
ATOM   3377 O OD1   . ASN A 1 435 ? -8.23146  0.65080   38.54571  1.000 107.61655 ? 429 ASN A OD1   1 ? 
ATOM   3378 N ND2   . ASN A 1 435 ? -8.53372  2.68397   37.64104  1.000 104.25901 ? 429 ASN A ND2   1 ? 
ATOM   3379 N N     . GLY A 1 436 ? -3.99794  3.73147   35.65855  1.000 96.42618  ? 430 GLY A N     1 ? 
ATOM   3380 C CA    . GLY A 1 436 ? -2.88639  4.64995   35.66082  1.000 89.76960  ? 430 GLY A CA    1 ? 
ATOM   3381 C C     . GLY A 1 436 ? -3.32240  6.04767   35.27435  1.000 87.17796  ? 430 GLY A C     1 ? 
ATOM   3382 O O     . GLY A 1 436 ? -4.50569  6.30961   35.03659  1.000 87.96678  ? 430 GLY A O     1 ? 
ATOM   3383 N N     . PRO A 1 437 ? -2.37442  6.97631   35.20637  1.000 80.24321  ? 431 PRO A N     1 ? 
ATOM   3384 C CA    . PRO A 1 437 ? -2.72034  8.35610   34.86079  1.000 78.72113  ? 431 PRO A CA    1 ? 
ATOM   3385 C C     . PRO A 1 437 ? -2.89297  8.54664   33.36368  1.000 77.61661  ? 431 PRO A C     1 ? 
ATOM   3386 O O     . PRO A 1 437 ? -2.28910  7.85236   32.54323  1.000 76.67936  ? 431 PRO A O     1 ? 
ATOM   3387 C CB    . PRO A 1 437 ? -1.52089  9.15650   35.37950  1.000 81.89293  ? 431 PRO A CB    1 ? 
ATOM   3388 C CG    . PRO A 1 437 ? -0.38163  8.20489   35.27923  1.000 75.39928  ? 431 PRO A CG    1 ? 
ATOM   3389 C CD    . PRO A 1 437 ? -0.94446  6.82636   35.52974  1.000 75.85787  ? 431 PRO A CD    1 ? 
ATOM   3390 N N     . LEU A 1 438 ? -3.73821  9.51249   33.01752  1.000 81.94767  ? 432 LEU A N     1 ? 
ATOM   3391 C CA    . LEU A 1 438 ? -3.93889  9.91778   31.62873  1.000 79.07929  ? 432 LEU A CA    1 ? 
ATOM   3392 C C     . LEU A 1 438 ? -2.94255  11.03008  31.32744  1.000 79.84272  ? 432 LEU A C     1 ? 
ATOM   3393 O O     . LEU A 1 438 ? -3.14962  12.18639  31.70412  1.000 83.78039  ? 432 LEU A O     1 ? 
ATOM   3394 C CB    . LEU A 1 438 ? -5.37649  10.36979  31.40674  1.000 81.74443  ? 432 LEU A CB    1 ? 
ATOM   3395 C CG    . LEU A 1 438 ? -5.74382  11.17395  30.15766  1.000 79.89504  ? 432 LEU A CG    1 ? 
ATOM   3396 C CD1   . LEU A 1 438 ? -5.09347  10.62779  28.88326  1.000 85.14890  ? 432 LEU A CD1   1 ? 
ATOM   3397 C CD2   . LEU A 1 438 ? -7.24886  11.21431  30.03053  1.000 77.53011  ? 432 LEU A CD2   1 ? 
ATOM   3398 N N     . ALA A 1 439 ? -1.86116  10.67963  30.64344  1.000 73.11754  ? 433 ALA A N     1 ? 
ATOM   3399 C CA    . ALA A 1 439 ? -0.79223  11.61981  30.32718  1.000 70.72833  ? 433 ALA A CA    1 ? 
ATOM   3400 C C     . ALA A 1 439 ? 0.10123   10.96861  29.27908  1.000 71.07078  ? 433 ALA A C     1 ? 
ATOM   3401 O O     . ALA A 1 439 ? -0.14610  9.84116   28.83911  1.000 67.68510  ? 433 ALA A O     1 ? 
ATOM   3402 C CB    . ALA A 1 439 ? -0.00059  12.00954  31.57784  1.000 70.19805  ? 433 ALA A CB    1 ? 
ATOM   3403 N N     . ASN A 1 440 ? 1.14140   11.69675  28.87584  1.000 72.95651  ? 434 ASN A N     1 ? 
ATOM   3404 C CA    . ASN A 1 440 ? 2.13452   11.15403  27.95742  1.000 73.50074  ? 434 ASN A CA    1 ? 
ATOM   3405 C C     . ASN A 1 440 ? 2.80373   9.93408   28.58047  1.000 75.55760  ? 434 ASN A C     1 ? 
ATOM   3406 O O     . ASN A 1 440 ? 3.20806   9.96286   29.74596  1.000 79.09521  ? 434 ASN A O     1 ? 
ATOM   3407 C CB    . ASN A 1 440 ? 3.17255   12.22657  27.62139  1.000 64.04935  ? 434 ASN A CB    1 ? 
ATOM   3408 C CG    . ASN A 1 440 ? 3.87345   11.97376  26.30059  1.000 73.27589  ? 434 ASN A CG    1 ? 
ATOM   3409 O OD1   . ASN A 1 440 ? 3.37704   11.23444  25.45076  1.000 72.29394  ? 434 ASN A OD1   1 ? 
ATOM   3410 N ND2   . ASN A 1 440 ? 5.03487   12.59493  26.12012  1.000 61.59559  ? 434 ASN A ND2   1 ? 
ATOM   3411 N N     . SER A 1 441 ? 2.91561   8.85617   27.80137  1.000 67.57465  ? 435 SER A N     1 ? 
ATOM   3412 C CA    . SER A 1 441 ? 3.36789   7.57313   28.33617  1.000 81.74674  ? 435 SER A CA    1 ? 
ATOM   3413 C C     . SER A 1 441 ? 4.82161   7.56461   28.81642  1.000 68.05562  ? 435 SER A C     1 ? 
ATOM   3414 O O     . SER A 1 441 ? 5.09229   6.96469   29.86451  1.000 67.71667  ? 435 SER A O     1 ? 
ATOM   3415 C CB    . SER A 1 441 ? 3.14956   6.44808   27.31335  1.000 78.13770  ? 435 SER A CB    1 ? 
ATOM   3416 O OG    . SER A 1 441 ? 3.66271   6.76314   26.03189  1.000 78.66193  ? 435 SER A OG    1 ? 
ATOM   3417 N N     . PRO A 1 442 ? 5.78328   8.17522   28.11588  1.000 71.24036  ? 436 PRO A N     1 ? 
ATOM   3418 C CA    . PRO A 1 442 ? 7.18072   8.11304   28.59059  1.000 68.99993  ? 436 PRO A CA    1 ? 
ATOM   3419 C C     . PRO A 1 442 ? 7.35561   8.72753   29.96972  1.000 67.37239  ? 436 PRO A C     1 ? 
ATOM   3420 O O     . PRO A 1 442 ? 8.06313   8.14590   30.80804  1.000 69.48197  ? 436 PRO A O     1 ? 
ATOM   3421 C CB    . PRO A 1 442 ? 7.96034   8.88483   27.51185  1.000 65.75972  ? 436 PRO A CB    1 ? 
ATOM   3422 C CG    . PRO A 1 442 ? 7.13379   8.74465   26.29349  1.000 70.49385  ? 436 PRO A CG    1 ? 
ATOM   3423 C CD    . PRO A 1 442 ? 5.71385   8.78743   26.77267  1.000 72.24608  ? 436 PRO A CD    1 ? 
ATOM   3424 N N     . PRO A 1 443 ? 6.75094   9.88898   30.27266  1.000 60.39045  ? 437 PRO A N     1 ? 
ATOM   3425 C CA    . PRO A 1 443 ? 6.82201   10.36969  31.66344  1.000 68.27978  ? 437 PRO A CA    1 ? 
ATOM   3426 C C     . PRO A 1 443 ? 6.14484   9.44460   32.66036  1.000 78.77705  ? 437 PRO A C     1 ? 
ATOM   3427 O O     . PRO A 1 443 ? 6.60306   9.34547   33.80581  1.000 71.26531  ? 437 PRO A O     1 ? 
ATOM   3428 C CB    . PRO A 1 443 ? 6.12825   11.73654  31.60012  1.000 59.85868  ? 437 PRO A CB    1 ? 
ATOM   3429 C CG    . PRO A 1 443 ? 6.31793   12.17866  30.21234  1.000 66.70660  ? 437 PRO A CG    1 ? 
ATOM   3430 C CD    . PRO A 1 443 ? 6.19035   10.93571  29.39372  1.000 66.55258  ? 437 PRO A CD    1 ? 
ATOM   3431 N N     . ILE A 1 444 ? 5.06524   8.76647   32.26481  1.000 65.81138  ? 438 ILE A N     1 ? 
ATOM   3432 C CA    . ILE A 1 444 ? 4.41121   7.82104   33.16583  1.000 64.03460  ? 438 ILE A CA    1 ? 
ATOM   3433 C C     . ILE A 1 444 ? 5.30259   6.60885   33.40014  1.000 66.85331  ? 438 ILE A C     1 ? 
ATOM   3434 O O     . ILE A 1 444 ? 5.47290   6.15144   34.53652  1.000 65.40799  ? 438 ILE A O     1 ? 
ATOM   3435 C CB    . ILE A 1 444 ? 3.03777   7.40467   32.60932  1.000 68.98656  ? 438 ILE A CB    1 ? 
ATOM   3436 C CG1   . ILE A 1 444 ? 2.14884   8.62908   32.39056  1.000 71.55360  ? 438 ILE A CG1   1 ? 
ATOM   3437 C CG2   . ILE A 1 444 ? 2.36376   6.40693   33.54181  1.000 57.18769  ? 438 ILE A CG2   1 ? 
ATOM   3438 C CD1   . ILE A 1 444 ? 0.87382   8.32415   31.63353  1.000 67.16814  ? 438 ILE A CD1   1 ? 
ATOM   3439 N N     . ILE A 1 445 ? 5.88284   6.07075   32.32541  1.000 62.35077  ? 439 ILE A N     1 ? 
ATOM   3440 C CA    . ILE A 1 445 ? 6.73018   4.88795   32.44383  1.000 60.66908  ? 439 ILE A CA    1 ? 
ATOM   3441 C C     . ILE A 1 445 ? 7.95738   5.19217   33.29376  1.000 64.62463  ? 439 ILE A C     1 ? 
ATOM   3442 O O     . ILE A 1 445 ? 8.35218   4.39075   34.14958  1.000 66.77170  ? 439 ILE A O     1 ? 
ATOM   3443 C CB    . ILE A 1 445 ? 7.11271   4.37055   31.04439  1.000 52.25311  ? 439 ILE A CB    1 ? 
ATOM   3444 C CG1   . ILE A 1 445 ? 5.98873   3.49798   30.47958  1.000 61.01148  ? 439 ILE A CG1   1 ? 
ATOM   3445 C CG2   . ILE A 1 445 ? 8.42897   3.60868   31.08785  1.000 59.00826  ? 439 ILE A CG2   1 ? 
ATOM   3446 C CD1   . ILE A 1 445 ? 6.00937   3.37181   28.97541  1.000 61.32142  ? 439 ILE A CD1   1 ? 
ATOM   3447 N N     . GLU A 1 446 ? 8.57282   6.35799   33.08207  1.000 64.19840  ? 440 GLU A N     1 ? 
ATOM   3448 C CA    . GLU A 1 446 ? 9.71481   6.74843   33.90297  1.000 69.21655  ? 440 GLU A CA    1 ? 
ATOM   3449 C C     . GLU A 1 446 ? 9.31776   6.89620   35.36590  1.000 68.46956  ? 440 GLU A C     1 ? 
ATOM   3450 O O     . GLU A 1 446 ? 10.07173  6.50590   36.26520  1.000 65.47623  ? 440 GLU A O     1 ? 
ATOM   3451 C CB    . GLU A 1 446 ? 10.31470  8.05296   33.38200  1.000 68.10877  ? 440 GLU A CB    1 ? 
ATOM   3452 C CG    . GLU A 1 446 ? 11.19296  7.89143   32.15825  1.000 68.16067  ? 440 GLU A CG    1 ? 
ATOM   3453 C CD    . GLU A 1 446 ? 11.89923  9.17763   31.78559  1.000 76.20702  ? 440 GLU A CD    1 ? 
ATOM   3454 O OE1   . GLU A 1 446 ? 11.79193  10.15969  32.55012  1.000 83.86972  ? 440 GLU A OE1   1 ? 
ATOM   3455 O OE2   . GLU A 1 446 ? 12.56531  9.20666   30.73157  1.000 69.29116  ? 440 GLU A OE2   1 ? 
ATOM   3456 N N     . THR A 1 447 ? 8.13428   7.45787   35.62212  1.000 65.68666  ? 441 THR A N     1 ? 
ATOM   3457 C CA    . THR A 1 447 ? 7.68094   7.64319   36.99652  1.000 64.86547  ? 441 THR A CA    1 ? 
ATOM   3458 C C     . THR A 1 447 ? 7.46052   6.30499   37.69187  1.000 73.66037  ? 441 THR A C     1 ? 
ATOM   3459 O O     . THR A 1 447 ? 7.83610   6.13217   38.85756  1.000 76.25201  ? 441 THR A O     1 ? 
ATOM   3460 C CB    . THR A 1 447 ? 6.39651   8.47415   37.01351  1.000 62.70040  ? 441 THR A CB    1 ? 
ATOM   3461 O OG1   . THR A 1 447 ? 6.65075   9.76346   36.44180  1.000 84.10080  ? 441 THR A OG1   1 ? 
ATOM   3462 C CG2   . THR A 1 447 ? 5.88849   8.65034   38.43449  1.000 61.88261  ? 441 THR A CG2   1 ? 
ATOM   3463 N N     . GLN A 1 448 ? 6.86458   5.34071   36.98811  1.000 71.92000  ? 442 GLN A N     1 ? 
ATOM   3464 C CA    . GLN A 1 448 ? 6.53360   4.06312   37.60942  1.000 68.92875  ? 442 GLN A CA    1 ? 
ATOM   3465 C C     . GLN A 1 448 ? 7.76089   3.17258   37.76707  1.000 72.02514  ? 442 GLN A C     1 ? 
ATOM   3466 O O     . GLN A 1 448 ? 7.88360   2.45751   38.76772  1.000 72.31503  ? 442 GLN A O     1 ? 
ATOM   3467 C CB    . GLN A 1 448 ? 5.45295   3.35140   36.79496  1.000 72.24636  ? 442 GLN A CB    1 ? 
ATOM   3468 C CG    . GLN A 1 448 ? 4.09319   4.02976   36.86074  1.000 73.45167  ? 442 GLN A CG    1 ? 
ATOM   3469 C CD    . GLN A 1 448 ? 3.12102   3.49766   35.82643  1.000 75.04837  ? 442 GLN A CD    1 ? 
ATOM   3470 O OE1   . GLN A 1 448 ? 3.52513   2.96911   34.79076  1.000 72.40198  ? 442 GLN A OE1   1 ? 
ATOM   3471 N NE2   . GLN A 1 448 ? 1.82932   3.63789   36.10194  1.000 70.62923  ? 442 GLN A NE2   1 ? 
ATOM   3472 N N     . VAL A 1 449 ? 8.67673   3.19783   36.79561  1.000 69.15475  ? 443 VAL A N     1 ? 
ATOM   3473 C CA    . VAL A 1 449 ? 9.88665   2.38953   36.91235  1.000 65.21588  ? 443 VAL A CA    1 ? 
ATOM   3474 C C     . VAL A 1 449 ? 10.76679  2.90401   38.04653  1.000 74.62422  ? 443 VAL A C     1 ? 
ATOM   3475 O O     . VAL A 1 449 ? 11.41898  2.11539   38.74183  1.000 77.76219  ? 443 VAL A O     1 ? 
ATOM   3476 C CB    . VAL A 1 449 ? 10.63700  2.35568   35.56608  1.000 63.64040  ? 443 VAL A CB    1 ? 
ATOM   3477 C CG1   . VAL A 1 449 ? 12.00975  1.71774   35.72210  1.000 57.75854  ? 443 VAL A CG1   1 ? 
ATOM   3478 C CG2   . VAL A 1 449 ? 9.82159   1.60000   34.52810  1.000 63.34762  ? 443 VAL A CG2   1 ? 
ATOM   3479 N N     . ARG A 1 450 ? 10.78702  4.22125   38.26991  1.000 75.66670  ? 444 ARG A N     1 ? 
ATOM   3480 C CA    . ARG A 1 450 ? 11.53611  4.76898   39.39769  1.000 75.60132  ? 444 ARG A CA    1 ? 
ATOM   3481 C C     . ARG A 1 450 ? 10.89962  4.38070   40.72616  1.000 76.17369  ? 444 ARG A C     1 ? 
ATOM   3482 O O     . ARG A 1 450 ? 11.60061  3.98063   41.66315  1.000 72.22143  ? 444 ARG A O     1 ? 
ATOM   3483 C CB    . ARG A 1 450 ? 11.63294  6.28970   39.27652  1.000 78.96570  ? 444 ARG A CB    1 ? 
ATOM   3484 C CG    . ARG A 1 450 ? 13.00163  6.81027   38.86086  1.000 84.80186  ? 444 ARG A CG    1 ? 
ATOM   3485 C CD    . ARG A 1 450 ? 13.96489  6.85228   40.03992  1.000 107.53017 ? 444 ARG A CD    1 ? 
ATOM   3486 N NE    . ARG A 1 450 ? 15.30493  7.26466   39.63779  1.000 115.08376 ? 444 ARG A NE    1 ? 
ATOM   3487 C CZ    . ARG A 1 450 ? 16.42350  6.87554   40.23455  1.000 118.93723 ? 444 ARG A CZ    1 ? 
ATOM   3488 N NH1   . ARG A 1 450 ? 16.40612  6.03617   41.25679  1.000 112.58075 ? 444 ARG A NH1   1 ? 
ATOM   3489 N NH2   . ARG A 1 450 ? 17.58994  7.33273   39.78759  1.000 116.66564 ? 444 ARG A NH2   1 ? 
ATOM   3490 N N     . TRP A 1 451 ? 9.57233   4.48966   40.82426  1.000 71.88176  ? 445 TRP A N     1 ? 
ATOM   3491 C CA    . TRP A 1 451 ? 8.88796   4.15481   42.06900  1.000 77.24471  ? 445 TRP A CA    1 ? 
ATOM   3492 C C     . TRP A 1 451 ? 9.00941   2.67025   42.38768  1.000 80.65041  ? 445 TRP A C     1 ? 
ATOM   3493 O O     . TRP A 1 451 ? 9.23165   2.29489   43.54476  1.000 82.21956  ? 445 TRP A O     1 ? 
ATOM   3494 C CB    . TRP A 1 451 ? 7.41824   4.56678   41.98267  1.000 77.50117  ? 445 TRP A CB    1 ? 
ATOM   3495 C CG    . TRP A 1 451 ? 6.66281   4.40127   43.26687  1.000 85.47649  ? 445 TRP A CG    1 ? 
ATOM   3496 C CD1   . TRP A 1 451 ? 6.44189   5.35665   44.21528  1.000 91.38227  ? 445 TRP A CD1   1 ? 
ATOM   3497 C CD2   . TRP A 1 451 ? 6.02131   3.20975   43.74098  1.000 93.05995  ? 445 TRP A CD2   1 ? 
ATOM   3498 N NE1   . TRP A 1 451 ? 5.70648   4.83439   45.25166  1.000 93.60310  ? 445 TRP A NE1   1 ? 
ATOM   3499 C CE2   . TRP A 1 451 ? 5.43533   3.51817   44.98481  1.000 92.87234  ? 445 TRP A CE2   1 ? 
ATOM   3500 C CE3   . TRP A 1 451 ? 5.88741   1.91250   43.23560  1.000 82.85234  ? 445 TRP A CE3   1 ? 
ATOM   3501 C CZ2   . TRP A 1 451 ? 4.72665   2.57781   45.73014  1.000 87.38453  ? 445 TRP A CZ2   1 ? 
ATOM   3502 C CZ3   . TRP A 1 451 ? 5.18359   0.98031   43.97726  1.000 84.95705  ? 445 TRP A CZ3   1 ? 
ATOM   3503 C CH2   . TRP A 1 451 ? 4.61216   1.31779   45.21053  1.000 90.88030  ? 445 TRP A CH2   1 ? 
ATOM   3504 N N     . ILE A 1 452 ? 8.86537   1.81229   41.37633  1.000 73.72037  ? 446 ILE A N     1 ? 
ATOM   3505 C CA    . ILE A 1 452 ? 8.93832   0.37229   41.60393  1.000 74.29103  ? 446 ILE A CA    1 ? 
ATOM   3506 C C     . ILE A 1 452 ? 10.35317  -0.03491  41.99681  1.000 75.33311  ? 446 ILE A C     1 ? 
ATOM   3507 O O     . ILE A 1 452 ? 10.55399  -0.81140  42.93827  1.000 77.96783  ? 446 ILE A O     1 ? 
ATOM   3508 C CB    . ILE A 1 452 ? 8.45639   -0.39215  40.35753  1.000 68.13096  ? 446 ILE A CB    1 ? 
ATOM   3509 C CG1   . ILE A 1 452 ? 6.93222   -0.32008  40.23981  1.000 68.22274  ? 446 ILE A CG1   1 ? 
ATOM   3510 C CG2   . ILE A 1 452 ? 8.92447   -1.83884  40.40138  1.000 68.65629  ? 446 ILE A CG2   1 ? 
ATOM   3511 C CD1   . ILE A 1 452 ? 6.41852   -0.54142  38.83357  1.000 72.54610  ? 446 ILE A CD1   1 ? 
ATOM   3512 N N     . ALA A 1 453 ? 11.35523  0.48964   41.28597  1.000 75.33466  ? 447 ALA A N     1 ? 
ATOM   3513 C CA    . ALA A 1 453 ? 12.73623  0.09508   41.54817  1.000 78.20489  ? 447 ALA A CA    1 ? 
ATOM   3514 C C     . ALA A 1 453 ? 13.17631  0.49910   42.94954  1.000 82.61004  ? 447 ALA A C     1 ? 
ATOM   3515 O O     . ALA A 1 453 ? 13.82239  -0.28504  43.65483  1.000 76.04963  ? 447 ALA A O     1 ? 
ATOM   3516 C CB    . ALA A 1 453 ? 13.66675  0.70434   40.49995  1.000 67.34174  ? 447 ALA A CB    1 ? 
ATOM   3517 N N     . ASP A 1 454 ? 12.83635  1.71911   43.37244  1.000 82.58005  ? 448 ASP A N     1 ? 
ATOM   3518 C CA    . ASP A 1 454 ? 13.23658  2.17182   44.70039  1.000 89.54284  ? 448 ASP A CA    1 ? 
ATOM   3519 C C     . ASP A 1 454 ? 12.52272  1.39374   45.79873  1.000 86.36274  ? 448 ASP A C     1 ? 
ATOM   3520 O O     . ASP A 1 454 ? 13.04501  1.27868   46.91339  1.000 86.62897  ? 448 ASP A O     1 ? 
ATOM   3521 C CB    . ASP A 1 454 ? 12.97808  3.67141   44.84464  1.000 90.45302  ? 448 ASP A CB    1 ? 
ATOM   3522 C CG    . ASP A 1 454 ? 14.02163  4.51234   44.13168  1.000 87.98726  ? 448 ASP A CG    1 ? 
ATOM   3523 O OD1   . ASP A 1 454 ? 14.37494  4.17554   42.98155  1.000 90.38760  ? 448 ASP A OD1   1 ? 
ATOM   3524 O OD2   . ASP A 1 454 ? 14.49144  5.50772   44.72174  1.000 93.32876  ? 448 ASP A OD2   1 ? 
ATOM   3525 N N     . LEU A 1 455 ? 11.33565  0.85593   45.50895  1.000 83.31902  ? 449 LEU A N     1 ? 
ATOM   3526 C CA    . LEU A 1 455 ? 10.68087  -0.03373  46.46231  1.000 83.34954  ? 449 LEU A CA    1 ? 
ATOM   3527 C C     . LEU A 1 455 ? 11.39883  -1.37624  46.53037  1.000 85.10469  ? 449 LEU A C     1 ? 
ATOM   3528 O O     . LEU A 1 455 ? 11.49810  -1.98192  47.60388  1.000 87.29434  ? 449 LEU A O     1 ? 
ATOM   3529 C CB    . LEU A 1 455 ? 9.20950   -0.21344  46.08312  1.000 80.02177  ? 449 LEU A CB    1 ? 
ATOM   3530 C CG    . LEU A 1 455 ? 8.39520   -1.34995  46.71019  1.000 86.83731  ? 449 LEU A CG    1 ? 
ATOM   3531 C CD1   . LEU A 1 455 ? 8.43403   -1.30216  48.23041  1.000 78.63115  ? 449 LEU A CD1   1 ? 
ATOM   3532 C CD2   . LEU A 1 455 ? 6.95847   -1.29741  46.21575  1.000 85.62025  ? 449 LEU A CD2   1 ? 
ATOM   3533 N N     . ILE A 1 456 ? 11.91486  -1.85159  45.39455  1.000 84.64481  ? 450 ILE A N     1 ? 
ATOM   3534 C CA    . ILE A 1 456 ? 12.73127  -3.06039  45.40025  1.000 82.29086  ? 450 ILE A CA    1 ? 
ATOM   3535 C C     . ILE A 1 456 ? 14.07271  -2.79270  46.07500  1.000 88.72909  ? 450 ILE A C     1 ? 
ATOM   3536 O O     . ILE A 1 456 ? 14.67522  -3.70085  46.66125  1.000 91.39456  ? 450 ILE A O     1 ? 
ATOM   3537 C CB    . ILE A 1 456 ? 12.89828  -3.58867  43.96199  1.000 82.55061  ? 450 ILE A CB    1 ? 
ATOM   3538 C CG1   . ILE A 1 456 ? 11.52760  -3.89130  43.34983  1.000 84.89177  ? 450 ILE A CG1   1 ? 
ATOM   3539 C CG2   . ILE A 1 456 ? 13.77236  -4.83447  43.93395  1.000 73.65306  ? 450 ILE A CG2   1 ? 
ATOM   3540 C CD1   . ILE A 1 456 ? 11.58785  -4.64384  42.03523  1.000 79.48977  ? 450 ILE A CD1   1 ? 
ATOM   3541 N N     . GLY A 1 457 ? 14.55803  -1.55081  46.01793  1.000 90.75821  ? 451 GLY A N     1 ? 
ATOM   3542 C CA    . GLY A 1 457 ? 15.75744  -1.20414  46.76522  1.000 88.93059  ? 451 GLY A CA    1 ? 
ATOM   3543 C C     . GLY A 1 457 ? 15.51367  -1.20144  48.26240  1.000 90.24411  ? 451 GLY A C     1 ? 
ATOM   3544 O O     . GLY A 1 457 ? 16.30392  -1.75194  49.03536  1.000 91.47215  ? 451 GLY A O     1 ? 
ATOM   3545 N N     . TYR A 1 458 ? 14.41661  -0.56764  48.69034  1.000 89.47005  ? 452 TYR A N     1 ? 
ATOM   3546 C CA    . TYR A 1 458 ? 13.94277  -0.71308  50.06269  1.000 90.70584  ? 452 TYR A CA    1 ? 
ATOM   3547 C C     . TYR A 1 458 ? 13.78546  -2.18465  50.42167  1.000 96.97433  ? 452 TYR A C     1 ? 
ATOM   3548 O O     . TYR A 1 458 ? 14.02455  -2.57802  51.56979  1.000 96.44365  ? 452 TYR A O     1 ? 
ATOM   3549 C CB    . TYR A 1 458 ? 12.62235  0.06212   50.21767  1.000 94.01949  ? 452 TYR A CB    1 ? 
ATOM   3550 C CG    . TYR A 1 458 ? 11.92256  0.01730   51.57239  1.000 93.83619  ? 452 TYR A CG    1 ? 
ATOM   3551 C CD1   . TYR A 1 458 ? 11.39132  -1.16408  52.08137  1.000 96.66383  ? 452 TYR A CD1   1 ? 
ATOM   3552 C CD2   . TYR A 1 458 ? 11.77258  1.17414   52.32899  1.000 97.53252  ? 452 TYR A CD2   1 ? 
ATOM   3553 C CE1   . TYR A 1 458 ? 10.74801  -1.19291  53.30567  1.000 102.07883 ? 452 TYR A CE1   1 ? 
ATOM   3554 C CE2   . TYR A 1 458 ? 11.13048  1.15391   53.55398  1.000 106.59145 ? 452 TYR A CE2   1 ? 
ATOM   3555 C CZ    . TYR A 1 458 ? 10.62037  -0.03177  54.03747  1.000 111.11440 ? 452 TYR A CZ    1 ? 
ATOM   3556 O OH    . TYR A 1 458 ? 9.98088   -0.05527  55.25669  1.000 116.07058 ? 452 TYR A OH    1 ? 
ATOM   3557 N N     . ALA A 1 459 ? 13.41027  -3.01472  49.44532  1.000 102.65227 ? 453 ALA A N     1 ? 
ATOM   3558 C CA    . ALA A 1 459 ? 13.26369  -4.44468  49.69416  1.000 96.01323  ? 453 ALA A CA    1 ? 
ATOM   3559 C C     . ALA A 1 459 ? 14.61938  -5.11975  49.89097  1.000 98.44347  ? 453 ALA A C     1 ? 
ATOM   3560 O O     . ALA A 1 459 ? 14.79303  -5.92540  50.81173  1.000 100.69010 ? 453 ALA A O     1 ? 
ATOM   3561 C CB    . ALA A 1 459 ? 12.48601  -5.09876  48.55033  1.000 89.11702  ? 453 ALA A CB    1 ? 
ATOM   3562 N N     . GLU A 1 460 ? 15.59361  -4.80738  49.03476  1.000 98.63760  ? 454 GLU A N     1 ? 
ATOM   3563 C CA    . GLU A 1 460 ? 16.92109  -5.40353  49.16898  1.000 102.30254 ? 454 GLU A CA    1 ? 
ATOM   3564 C C     . GLU A 1 460 ? 17.57044  -5.04091  50.50260  1.000 105.07580 ? 454 GLU A C     1 ? 
ATOM   3565 O O     . GLU A 1 460 ? 18.23463  -5.87609  51.12985  1.000 107.28050 ? 454 GLU A O     1 ? 
ATOM   3566 C CB    . GLU A 1 460 ? 17.80124  -4.94375  48.00927  1.000 103.23221 ? 454 GLU A CB    1 ? 
ATOM   3567 C CG    . GLU A 1 460 ? 17.76107  -5.78189  46.75077  1.000 108.91019 ? 454 GLU A CG    1 ? 
ATOM   3568 C CD    . GLU A 1 460 ? 17.96440  -7.26931  47.02124  1.000 113.69937 ? 454 GLU A CD    1 ? 
ATOM   3569 O OE1   . GLU A 1 460 ? 19.13297  -7.71170  47.12778  1.000 119.10597 ? 454 GLU A OE1   1 ? 
ATOM   3570 O OE2   . GLU A 1 460 ? 16.96808  -8.01256  47.12634  1.000 112.60204 ? 454 GLU A OE2   1 ? 
ATOM   3571 N N     . ASP A 1 461 ? 17.37914  -3.80291  50.96042  1.000 104.85122 ? 455 ASP A N     1 ? 
ATOM   3572 C CA    . ASP A 1 461 ? 18.10163  -3.33172  52.13846  1.000 109.38927 ? 455 ASP A CA    1 ? 
ATOM   3573 C C     . ASP A 1 461 ? 17.48235  -3.85272  53.43131  1.000 109.40579 ? 455 ASP A C     1 ? 
ATOM   3574 O O     . ASP A 1 461 ? 18.19123  -4.36760  54.30330  1.000 114.71707 ? 455 ASP A O     1 ? 
ATOM   3575 C CB    . ASP A 1 461 ? 18.15229  -1.80240  52.14703  1.000 102.84480 ? 455 ASP A CB    1 ? 
ATOM   3576 C CG    . ASP A 1 461 ? 19.06798  -1.24437  51.07440  1.000 104.94254 ? 455 ASP A CG    1 ? 
ATOM   3577 O OD1   . ASP A 1 461 ? 19.66734  -2.04623  50.32724  1.000 104.89533 ? 455 ASP A OD1   1 ? 
ATOM   3578 O OD2   . ASP A 1 461 ? 19.18057  -0.00476  50.97058  1.000 103.27004 ? 455 ASP A OD2   1 ? 
ATOM   3579 N N     . HIS A 1 462 ? 16.16536  -3.72961  53.57366  1.000 103.86991 ? 456 HIS A N     1 ? 
ATOM   3580 C CA    . HIS A 1 462 ? 15.48495  -4.11340  54.80363  1.000 105.58077 ? 456 HIS A CA    1 ? 
ATOM   3581 C C     . HIS A 1 462 ? 15.20543  -5.61031  54.89404  1.000 110.64227 ? 456 HIS A C     1 ? 
ATOM   3582 O O     . HIS A 1 462 ? 14.44690  -6.02493  55.77741  1.000 110.63419 ? 456 HIS A O     1 ? 
ATOM   3583 C CB    . HIS A 1 462 ? 14.18157  -3.32312  54.94609  1.000 105.20518 ? 456 HIS A CB    1 ? 
ATOM   3584 C CG    . HIS A 1 462 ? 14.38522  -1.90024  55.36633  1.000 114.12434 ? 456 HIS A CG    1 ? 
ATOM   3585 N ND1   . HIS A 1 462 ? 13.76600  -1.35370  56.46930  1.000 115.95556 ? 456 HIS A ND1   1 ? 
ATOM   3586 C CD2   . HIS A 1 462 ? 15.14474  -0.91357  54.83365  1.000 110.59037 ? 456 HIS A CD2   1 ? 
ATOM   3587 C CE1   . HIS A 1 462 ? 14.13314  -0.09071  56.59722  1.000 114.09381 ? 456 HIS A CE1   1 ? 
ATOM   3588 N NE2   . HIS A 1 462 ? 14.96910  0.20113   55.61743  1.000 106.61814 ? 456 HIS A NE2   1 ? 
ATOM   3589 N N     . GLN A 1 463 ? 15.79675  -6.41541  54.01222  1.000 113.14153 ? 457 GLN A N     1 ? 
ATOM   3590 C CA    . GLN A 1 463 ? 15.71424  -7.87556  54.06486  1.000 108.88805 ? 457 GLN A CA    1 ? 
ATOM   3591 C C     . GLN A 1 463 ? 14.26144  -8.35230  54.10203  1.000 106.36487 ? 457 GLN A C     1 ? 
ATOM   3592 O O     . GLN A 1 463 ? 13.78554  -8.93066  55.08071  1.000 109.63493 ? 457 GLN A O     1 ? 
ATOM   3593 C CB    . GLN A 1 463 ? 16.50363  -8.42032  55.25762  1.000 109.46199 ? 457 GLN A CB    1 ? 
ATOM   3594 C CG    . GLN A 1 463 ? 17.36605  -9.62772  54.92652  1.000 129.05993 ? 457 GLN A CG    1 ? 
ATOM   3595 C CD    . GLN A 1 463 ? 18.67225  -9.24506  54.25893  1.000 132.48813 ? 457 GLN A CD    1 ? 
ATOM   3596 O OE1   . GLN A 1 463 ? 19.43538  -8.43438  54.78331  1.000 134.24250 ? 457 GLN A OE1   1 ? 
ATOM   3597 N NE2   . GLN A 1 463 ? 18.93660  -9.82852  53.09531  1.000 124.06862 ? 457 GLN A NE2   1 ? 
ATOM   3598 N N     . ILE A 1 464 ? 13.56057  -8.09776  53.00136  1.000 103.88781 ? 458 ILE A N     1 ? 
ATOM   3599 C CA    . ILE A 1 464 ? 12.16613  -8.48551  52.83410  1.000 101.45475 ? 458 ILE A CA    1 ? 
ATOM   3600 C C     . ILE A 1 464 ? 12.01441  -9.20020  51.49902  1.000 102.03041 ? 458 ILE A C     1 ? 
ATOM   3601 O O     . ILE A 1 464 ? 12.63304  -8.81130  50.50127  1.000 103.82188 ? 458 ILE A O     1 ? 
ATOM   3602 C CB    . ILE A 1 464 ? 11.22565  -7.26437  52.93068  1.000 102.50947 ? 458 ILE A CB    1 ? 
ATOM   3603 C CG1   . ILE A 1 464 ? 9.93538   -7.50374  52.14642  1.000 98.63682  ? 458 ILE A CG1   1 ? 
ATOM   3604 C CG2   . ILE A 1 464 ? 11.93590  -5.99627  52.50088  1.000 101.64849 ? 458 ILE A CG2   1 ? 
ATOM   3605 C CD1   . ILE A 1 464 ? 8.76751   -6.76567  52.69064  1.000 93.77473  ? 458 ILE A CD1   1 ? 
ATOM   3606 N N     . ASN A 1 465 ? 11.18612  -10.24690 51.48106  1.000 98.31473  ? 459 ASN A N     1 ? 
ATOM   3607 C CA    . ASN A 1 465 ? 11.08112  -11.13774 50.33644  1.000 105.02752 ? 459 ASN A CA    1 ? 
ATOM   3608 C C     . ASN A 1 465 ? 9.69452   -11.19583 49.70790  1.000 102.45597 ? 459 ASN A C     1 ? 
ATOM   3609 O O     . ASN A 1 465 ? 9.51535   -11.92260 48.72347  1.000 101.02301 ? 459 ASN A O     1 ? 
ATOM   3610 C CB    . ASN A 1 465 ? 11.50810  -12.55388 50.74373  1.000 102.22446 ? 459 ASN A CB    1 ? 
ATOM   3611 C CG    . ASN A 1 465 ? 10.70346  -13.08718 51.91284  1.000 105.34988 ? 459 ASN A CG    1 ? 
ATOM   3612 O OD1   . ASN A 1 465 ? 10.26221  -12.32716 52.77618  1.000 106.44068 ? 459 ASN A OD1   1 ? 
ATOM   3613 N ND2   . ASN A 1 465 ? 10.50869  -14.39943 51.94736  1.000 114.70370 ? 459 ASN A ND2   1 ? 
ATOM   3614 N N     . GLN A 1 466 ? 8.71061   -10.46678 50.23223  1.000 93.33649  ? 460 GLN A N     1 ? 
ATOM   3615 C CA    . GLN A 1 466 ? 7.36406   -10.51857 49.66866  1.000 93.07085  ? 460 GLN A CA    1 ? 
ATOM   3616 C C     . GLN A 1 466 ? 6.64208   -9.21045  49.95005  1.000 99.48406  ? 460 GLN A C     1 ? 
ATOM   3617 O O     . GLN A 1 466 ? 6.41454   -8.86363  51.11289  1.000 96.06441  ? 460 GLN A O     1 ? 
ATOM   3618 C CB    . GLN A 1 466 ? 6.57464   -11.70251 50.23595  1.000 87.06064  ? 460 GLN A CB    1 ? 
ATOM   3619 C CG    . GLN A 1 466 ? 5.08168   -11.65328 49.94133  1.000 87.97511  ? 460 GLN A CG    1 ? 
ATOM   3620 C CD    . GLN A 1 466 ? 4.37452   -12.95353 50.27675  1.000 90.92767  ? 460 GLN A CD    1 ? 
ATOM   3621 O OE1   . GLN A 1 466 ? 3.24288   -12.95157 50.76291  1.000 84.81790  ? 460 GLN A OE1   1 ? 
ATOM   3622 N NE2   . GLN A 1 466 ? 5.03944   -14.07316 50.01542  1.000 82.23811  ? 460 GLN A NE2   1 ? 
ATOM   3623 N N     . ILE A 1 467 ? 6.28319   -8.49373  48.88671  1.000 99.09769  ? 461 ILE A N     1 ? 
ATOM   3624 C CA    . ILE A 1 467 ? 5.48985   -7.27288  48.97040  1.000 92.58687  ? 461 ILE A CA    1 ? 
ATOM   3625 C C     . ILE A 1 467 ? 4.15566   -7.52589  48.28454  1.000 89.79213  ? 461 ILE A C     1 ? 
ATOM   3626 O O     . ILE A 1 467 ? 4.09913   -8.20125  47.25062  1.000 82.99739  ? 461 ILE A O     1 ? 
ATOM   3627 C CB    . ILE A 1 467 ? 6.21480   -6.07374  48.32829  1.000 86.33010  ? 461 ILE A CB    1 ? 
ATOM   3628 C CG1   . ILE A 1 467 ? 7.71269   -6.12536  48.63422  1.000 83.64098  ? 461 ILE A CG1   1 ? 
ATOM   3629 C CG2   . ILE A 1 467 ? 5.61109   -4.76351  48.81177  1.000 90.08529  ? 461 ILE A CG2   1 ? 
ATOM   3630 C CD1   . ILE A 1 467 ? 8.53519   -5.15504  47.81540  1.000 69.56749  ? 461 ILE A CD1   1 ? 
ATOM   3631 N N     . GLU A 1 468 ? 3.08356   -6.98051  48.85607  1.000 89.28531  ? 462 GLU A N     1 ? 
ATOM   3632 C CA    . GLU A 1 468 ? 1.74658   -7.20944  48.32714  1.000 82.94723  ? 462 GLU A CA    1 ? 
ATOM   3633 C C     . GLU A 1 468 ? 0.83258   -6.07443  48.76488  1.000 96.38491  ? 462 GLU A C     1 ? 
ATOM   3634 O O     . GLU A 1 468 ? 0.87800   -5.64561  49.92028  1.000 97.38610  ? 462 GLU A O     1 ? 
ATOM   3635 C CB    . GLU A 1 468 ? 1.18959   -8.55848  48.80093  1.000 103.79431 ? 462 GLU A CB    1 ? 
ATOM   3636 C CG    . GLU A 1 468 ? -0.31044  -8.57674  49.05018  1.000 108.28281 ? 462 GLU A CG    1 ? 
ATOM   3637 C CD    . GLU A 1 468 ? -0.88446  -9.97989  49.04986  1.000 110.93201 ? 462 GLU A CD    1 ? 
ATOM   3638 O OE1   . GLU A 1 468 ? -0.27629  -10.87236 49.67750  1.000 107.88583 ? 462 GLU A OE1   1 ? 
ATOM   3639 O OE2   . GLU A 1 468 ? -1.94476  -10.19007 48.42381  1.000 114.29590 ? 462 GLU A OE2   1 ? 
ATOM   3640 N N     . ALA A 1 469 ? 0.00980   -5.59513  47.83614  1.000 96.37930  ? 463 ALA A N     1 ? 
ATOM   3641 C CA    . ALA A 1 469 ? -0.97366  -4.57079  48.15003  1.000 98.05362  ? 463 ALA A CA    1 ? 
ATOM   3642 C C     . ALA A 1 469 ? -2.21943  -5.19809  48.76524  1.000 100.13377 ? 463 ALA A C     1 ? 
ATOM   3643 O O     . ALA A 1 469 ? -2.61196  -6.31679  48.42229  1.000 103.27056 ? 463 ALA A O     1 ? 
ATOM   3644 C CB    . ALA A 1 469 ? -1.35100  -3.78416  46.89422  1.000 101.82941 ? 463 ALA A CB    1 ? 
ATOM   3645 N N     . THR A 1 470 ? -2.84027  -4.46667  49.68667  1.000 99.05416  ? 464 THR A N     1 ? 
ATOM   3646 C CA    . THR A 1 470 ? -4.05886  -4.94428  50.32289  1.000 103.53244 ? 464 THR A CA    1 ? 
ATOM   3647 C C     . THR A 1 470 ? -5.25884  -4.77202  49.40033  1.000 103.55125 ? 464 THR A C     1 ? 
ATOM   3648 O O     . THR A 1 470 ? -5.28480  -3.89584  48.53102  1.000 104.99180 ? 464 THR A O     1 ? 
ATOM   3649 C CB    . THR A 1 470 ? -4.32032  -4.20846  51.64009  1.000 98.33142  ? 464 THR A CB    1 ? 
ATOM   3650 O OG1   . THR A 1 470 ? -5.04884  -3.00011  51.38216  1.000 99.84275  ? 464 THR A OG1   1 ? 
ATOM   3651 C CG2   . THR A 1 470 ? -3.01832  -3.88600  52.35555  1.000 94.62111  ? 464 THR A CG2   1 ? 
ATOM   3652 N N     . LYS A 1 471 ? -6.26103  -5.63228  49.60055  1.000 102.72786 ? 465 LYS A N     1 ? 
ATOM   3653 C CA    . LYS A 1 471 ? -7.51779  -5.49370  48.87342  1.000 103.55981 ? 465 LYS A CA    1 ? 
ATOM   3654 C C     . LYS A 1 471 ? -8.19410  -4.16604  49.19028  1.000 102.68834 ? 465 LYS A C     1 ? 
ATOM   3655 O O     . LYS A 1 471 ? -8.91603  -3.61845  48.34916  1.000 102.29884 ? 465 LYS A O     1 ? 
ATOM   3656 C CB    . LYS A 1 471 ? -8.43488  -6.67868  49.20286  1.000 100.19672 ? 465 LYS A CB    1 ? 
ATOM   3657 C CG    . LYS A 1 471 ? -9.88543  -6.55256  48.74114  1.000 100.77914 ? 465 LYS A CG    1 ? 
ATOM   3658 C CD    . LYS A 1 471 ? -10.79983 -6.04095  49.84862  1.000 102.06847 ? 465 LYS A CD    1 ? 
ATOM   3659 C CE    . LYS A 1 471 ? -12.23698 -6.49339  49.63529  1.000 95.86564  ? 465 LYS A CE    1 ? 
ATOM   3660 N NZ    . LYS A 1 471 ? -12.84484 -5.85970  48.43162  1.000 88.70836  ? 465 LYS A NZ    1 ? 
ATOM   3661 N N     . ASP A 1 472 ? -7.95962  -3.62651  50.38782  1.000 106.55561 ? 466 ASP A N     1 ? 
ATOM   3662 C CA    . ASP A 1 472 ? -8.58000  -2.36738  50.77940  1.000 108.96646 ? 466 ASP A CA    1 ? 
ATOM   3663 C C     . ASP A 1 472 ? -7.87907  -1.16395  50.16217  1.000 107.25407 ? 466 ASP A C     1 ? 
ATOM   3664 O O     . ASP A 1 472 ? -8.52529  -0.14111  49.90815  1.000 104.78261 ? 466 ASP A O     1 ? 
ATOM   3665 C CB    . ASP A 1 472 ? -8.59081  -2.24794  52.30301  1.000 108.24543 ? 466 ASP A CB    1 ? 
ATOM   3666 C CG    . ASP A 1 472 ? -9.04499  -3.52536  52.98117  1.000 114.64002 ? 466 ASP A CG    1 ? 
ATOM   3667 O OD1   . ASP A 1 472 ? -10.24858 -3.84938  52.89825  1.000 121.82207 ? 466 ASP A OD1   1 ? 
ATOM   3668 O OD2   . ASP A 1 472 ? -8.19665  -4.20989  53.59126  1.000 115.60671 ? 466 ASP A OD2   1 ? 
ATOM   3669 N N     . ALA A 1 473 ? -6.56989  -1.26098  49.91786  1.000 101.92903 ? 467 ALA A N     1 ? 
ATOM   3670 C CA    . ALA A 1 473 ? -5.85535  -0.15419  49.29040  1.000 100.50339 ? 467 ALA A CA    1 ? 
ATOM   3671 C C     . ALA A 1 473 ? -6.25512  0.00181   47.82864  1.000 104.87444 ? 467 ALA A C     1 ? 
ATOM   3672 O O     . ALA A 1 473 ? -6.45638  1.12493   47.35103  1.000 106.22392 ? 467 ALA A O     1 ? 
ATOM   3673 C CB    . ALA A 1 473 ? -4.34662  -0.36075  49.41848  1.000 98.36768  ? 467 ALA A CB    1 ? 
ATOM   3674 N N     . VAL A 1 474 ? -6.37569  -1.11294  47.10163  1.000 102.00937 ? 468 VAL A N     1 ? 
ATOM   3675 C CA    . VAL A 1 474 ? -6.82686  -1.04729  45.71742  1.000 99.70620  ? 468 VAL A CA    1 ? 
ATOM   3676 C C     . VAL A 1 474 ? -8.28220  -0.61027  45.63102  1.000 103.61979 ? 468 VAL A C     1 ? 
ATOM   3677 O O     . VAL A 1 474 ? -8.71040  -0.09551  44.59148  1.000 106.87494 ? 468 VAL A O     1 ? 
ATOM   3678 C CB    . VAL A 1 474 ? -6.61590  -2.39969  45.00759  1.000 90.96062  ? 468 VAL A CB    1 ? 
ATOM   3679 C CG1   . VAL A 1 474 ? -5.26113  -2.98501  45.37028  1.000 94.28266  ? 468 VAL A CG1   1 ? 
ATOM   3680 C CG2   . VAL A 1 474 ? -7.73227  -3.37492  45.34973  1.000 92.49285  ? 468 VAL A CG2   1 ? 
ATOM   3681 N N     . ASP A 1 475 ? -9.05828  -0.80026  46.70134  1.000 105.21067 ? 469 ASP A N     1 ? 
ATOM   3682 C CA    . ASP A 1 475 ? -10.41538 -0.26785  46.72840  1.000 109.35985 ? 469 ASP A CA    1 ? 
ATOM   3683 C C     . ASP A 1 475 ? -10.40134 1.24408   46.90385  1.000 112.63565 ? 469 ASP A C     1 ? 
ATOM   3684 O O     . ASP A 1 475 ? -11.17170 1.95814   46.25165  1.000 102.91037 ? 469 ASP A O     1 ? 
ATOM   3685 C CB    . ASP A 1 475 ? -11.22207 -0.93475  47.84187  1.000 114.40209 ? 469 ASP A CB    1 ? 
ATOM   3686 C CG    . ASP A 1 475 ? -11.66218 -2.33925  47.48023  1.000 116.63719 ? 469 ASP A CG    1 ? 
ATOM   3687 O OD1   . ASP A 1 475 ? -11.04457 -2.94313  46.57795  1.000 105.61714 ? 469 ASP A OD1   1 ? 
ATOM   3688 O OD2   . ASP A 1 475 ? -12.62572 -2.83937  48.09785  1.000 127.49486 ? 469 ASP A OD2   1 ? 
ATOM   3689 N N     . ASN A 1 476 ? -9.52775  1.74992   47.77783  1.000 110.71038 ? 470 ASN A N     1 ? 
ATOM   3690 C CA    . ASN A 1 476 ? -9.38384  3.19388   47.92242  1.000 106.84999 ? 470 ASN A CA    1 ? 
ATOM   3691 C C     . ASN A 1 476 ? -8.85209  3.82170   46.64114  1.000 107.38671 ? 470 ASN A C     1 ? 
ATOM   3692 O O     . ASN A 1 476 ? -9.26680  4.92338   46.26324  1.000 108.41891 ? 470 ASN A O     1 ? 
ATOM   3693 C CB    . ASN A 1 476 ? -8.46420  3.51703   49.09969  1.000 99.33303  ? 470 ASN A CB    1 ? 
ATOM   3694 C CG    . ASN A 1 476 ? -7.98793  4.95698   49.08777  1.000 110.01787 ? 470 ASN A CG    1 ? 
ATOM   3695 O OD1   . ASN A 1 476 ? -8.77760  5.88587   49.25961  1.000 102.73123 ? 470 ASN A OD1   1 ? 
ATOM   3696 N ND2   . ASN A 1 476 ? -6.69023  5.14947   48.87983  1.000 116.20518 ? 470 ASN A ND2   1 ? 
ATOM   3697 N N     . TRP A 1 477 ? -7.93755  3.13146   45.95379  1.000 105.83715 ? 471 TRP A N     1 ? 
ATOM   3698 C CA    . TRP A 1 477 ? -7.38869  3.67188   44.71434  1.000 104.02655 ? 471 TRP A CA    1 ? 
ATOM   3699 C C     . TRP A 1 477 ? -8.43387  3.69020   43.60608  1.000 105.67536 ? 471 TRP A C     1 ? 
ATOM   3700 O O     . TRP A 1 477 ? -8.46662  4.62077   42.79293  1.000 105.09382 ? 471 TRP A O     1 ? 
ATOM   3701 C CB    . TRP A 1 477 ? -6.16265  2.87099   44.27871  1.000 99.04175  ? 471 TRP A CB    1 ? 
ATOM   3702 C CG    . TRP A 1 477 ? -5.54296  3.39944   43.02078  1.000 102.07193 ? 471 TRP A CG    1 ? 
ATOM   3703 C CD1   . TRP A 1 477 ? -5.45775  2.76242   41.81720  1.000 98.57651  ? 471 TRP A CD1   1 ? 
ATOM   3704 C CD2   . TRP A 1 477 ? -4.93413  4.68395   42.83862  1.000 102.68394 ? 471 TRP A CD2   1 ? 
ATOM   3705 N NE1   . TRP A 1 477 ? -4.82773  3.56720   40.89900  1.000 100.00942 ? 471 TRP A NE1   1 ? 
ATOM   3706 C CE2   . TRP A 1 477 ? -4.49742  4.75298   41.50087  1.000 103.36163 ? 471 TRP A CE2   1 ? 
ATOM   3707 C CE3   . TRP A 1 477 ? -4.71337  5.78084   43.67771  1.000 95.21907  ? 471 TRP A CE3   1 ? 
ATOM   3708 C CZ2   . TRP A 1 477 ? -3.85214  5.87429   40.98328  1.000 94.47055  ? 471 TRP A CZ2   1 ? 
ATOM   3709 C CZ3   . TRP A 1 477 ? -4.07364  6.89313   43.16174  1.000 92.69246  ? 471 TRP A CZ3   1 ? 
ATOM   3710 C CH2   . TRP A 1 477 ? -3.65044  6.93132   41.82750  1.000 92.70555  ? 471 TRP A CH2   1 ? 
ATOM   3711 N N     . THR A 1 478 ? -9.29202  2.66976   43.54910  1.000 102.00933 ? 472 THR A N     1 ? 
ATOM   3712 C CA    . THR A 1 478 ? -10.37736 2.68370   42.57650  1.000 103.11953 ? 472 THR A CA    1 ? 
ATOM   3713 C C     . THR A 1 478 ? -11.47325 3.66773   42.95996  1.000 102.98644 ? 472 THR A C     1 ? 
ATOM   3714 O O     . THR A 1 478 ? -12.28474 4.03792   42.10494  1.000 101.74590 ? 472 THR A O     1 ? 
ATOM   3715 C CB    . THR A 1 478 ? -10.97108 1.28358   42.41524  1.000 97.40086  ? 472 THR A CB    1 ? 
ATOM   3716 O OG1   . THR A 1 478 ? -11.01601 0.63087   43.68941  1.000 108.91140 ? 472 THR A OG1   1 ? 
ATOM   3717 C CG2   . THR A 1 478 ? -10.12756 0.45707   41.45725  1.000 82.53882  ? 472 THR A CG2   1 ? 
ATOM   3718 N N     . ASN A 1 479 ? -11.51327 4.09936   44.22204  1.000 106.05776 ? 473 ASN A N     1 ? 
ATOM   3719 C CA    . ASN A 1 479 ? -12.50242 5.08580   44.63921  1.000 107.09212 ? 473 ASN A CA    1 ? 
ATOM   3720 C C     . ASN A 1 479 ? -12.06118 6.50293   44.29368  1.000 104.90798 ? 473 ASN A C     1 ? 
ATOM   3721 O O     . ASN A 1 479 ? -12.87814 7.31264   43.84184  1.000 102.96924 ? 473 ASN A O     1 ? 
ATOM   3722 C CB    . ASN A 1 479 ? -12.77676 4.95552   46.13755  1.000 107.03521 ? 473 ASN A CB    1 ? 
ATOM   3723 C CG    . ASN A 1 479 ? -13.82099 3.89987   46.44778  1.000 109.32040 ? 473 ASN A CG    1 ? 
ATOM   3724 O OD1   . ASN A 1 479 ? -13.79598 2.80133   45.89256  1.000 113.22407 ? 473 ASN A OD1   1 ? 
ATOM   3725 N ND2   . ASN A 1 479 ? -14.74714 4.22953   47.34015  1.000 109.42687 ? 473 ASN A ND2   1 ? 
ATOM   3726 N N     . THR A 1 480 ? -10.77913 6.82450   44.49422  1.000 101.51818 ? 474 THR A N     1 ? 
ATOM   3727 C CA    . THR A 1 480 ? -10.28784 8.13801   44.09292  1.000 107.12869 ? 474 THR A CA    1 ? 
ATOM   3728 C C     . THR A 1 480 ? -10.19819 8.27240   42.57932  1.000 103.80174 ? 474 THR A C     1 ? 
ATOM   3729 O O     . THR A 1 480 ? -10.16048 9.39750   42.07080  1.000 108.58546 ? 474 THR A O     1 ? 
ATOM   3730 C CB    . THR A 1 480 ? -8.91928  8.42616   44.71666  1.000 105.24593 ? 474 THR A CB    1 ? 
ATOM   3731 O OG1   . THR A 1 480 ? -8.32877  9.56033   44.06979  1.000 107.68122 ? 474 THR A OG1   1 ? 
ATOM   3732 C CG2   . THR A 1 480 ? -7.99335  7.24035   44.54668  1.000 102.15242 ? 474 THR A CG2   1 ? 
ATOM   3733 N N     . CYS A 1 481 ? -10.16110 7.15410   41.85053  1.000 103.37268 ? 475 CYS A N     1 ? 
ATOM   3734 C CA    . CYS A 1 481 ? -10.20905 7.22341   40.39414  1.000 104.36776 ? 475 CYS A CA    1 ? 
ATOM   3735 C C     . CYS A 1 481 ? -11.61348 7.56061   39.90973  1.000 103.56105 ? 475 CYS A C     1 ? 
ATOM   3736 O O     . CYS A 1 481 ? -11.78497 8.40541   39.02320  1.000 97.80958  ? 475 CYS A O     1 ? 
ATOM   3737 C CB    . CYS A 1 481 ? -9.73010  5.90472   39.78835  1.000 96.91512  ? 475 CYS A CB    1 ? 
ATOM   3738 S SG    . CYS A 1 481 ? -7.93936  5.67575   39.83563  1.000 95.82795  ? 475 CYS A SG    1 ? 
ATOM   3739 N N     . SER A 1 482 ? -12.63119 6.90960   40.47951  1.000 102.80920 ? 476 SER A N     1 ? 
ATOM   3740 C CA    . SER A 1 482 ? -14.00807 7.26720   40.15716  1.000 97.33029  ? 476 SER A CA    1 ? 
ATOM   3741 C C     . SER A 1 482 ? -14.39226 8.60711   40.77010  1.000 103.79098 ? 476 SER A C     1 ? 
ATOM   3742 O O     . SER A 1 482 ? -15.30942 9.27307   40.27641  1.000 102.20247 ? 476 SER A O     1 ? 
ATOM   3743 C CB    . SER A 1 482 ? -14.96166 6.17160   40.63208  1.000 98.59630  ? 476 SER A CB    1 ? 
ATOM   3744 O OG    . SER A 1 482 ? -14.26742 5.17269   41.35876  1.000 97.66158  ? 476 SER A OG    1 ? 
ATOM   3745 N N     . ASP A 1 483 ? -13.70955 9.01179   41.84405  1.000 107.84811 ? 477 ASP A N     1 ? 
ATOM   3746 C CA    . ASP A 1 483 ? -13.94402 10.32818  42.42940  1.000 107.16675 ? 477 ASP A CA    1 ? 
ATOM   3747 C C     . ASP A 1 483 ? -13.64647 11.43260  41.42323  1.000 109.66122 ? 477 ASP A C     1 ? 
ATOM   3748 O O     . ASP A 1 483 ? -14.46546 12.33380  41.20807  1.000 112.19936 ? 477 ASP A O     1 ? 
ATOM   3749 C CB    . ASP A 1 483 ? -13.08562 10.49847  43.68419  1.000 118.07246 ? 477 ASP A CB    1 ? 
ATOM   3750 C CG    . ASP A 1 483 ? -13.65560 11.51697  44.65079  1.000 125.77514 ? 477 ASP A CG    1 ? 
ATOM   3751 O OD1   . ASP A 1 483 ? -14.89628 11.61110  44.75782  1.000 115.57316 ? 477 ASP A OD1   1 ? 
ATOM   3752 O OD2   . ASP A 1 483 ? -12.85952 12.22449  45.30426  1.000 130.59416 ? 477 ASP A OD2   1 ? 
ATOM   3753 N N     . ILE A 1 484 ? -12.47395 11.37240  40.79011  1.000 107.48545 ? 478 ILE A N     1 ? 
ATOM   3754 C CA    . ILE A 1 484 ? -12.09285 12.40128  39.82893  1.000 106.78740 ? 478 ILE A CA    1 ? 
ATOM   3755 C C     . ILE A 1 484 ? -12.84266 12.21461  38.51597  1.000 105.98279 ? 478 ILE A C     1 ? 
ATOM   3756 O O     . ILE A 1 484 ? -13.25120 13.19099  37.87557  1.000 106.58930 ? 478 ILE A O     1 ? 
ATOM   3757 C CB    . ILE A 1 484 ? -10.56827 12.38798  39.61590  1.000 102.14857 ? 478 ILE A CB    1 ? 
ATOM   3758 C CG1   . ILE A 1 484 ? -9.84127  12.63268  40.93892  1.000 102.14795 ? 478 ILE A CG1   1 ? 
ATOM   3759 C CG2   . ILE A 1 484 ? -10.16200 13.42920  38.58548  1.000 95.29798  ? 478 ILE A CG2   1 ? 
ATOM   3760 C CD1   . ILE A 1 484 ? -8.43445  12.08053  40.96909  1.000 98.94783  ? 478 ILE A CD1   1 ? 
ATOM   3761 N N     . ALA A 1 485 ? -13.04231 10.96116  38.09825  1.000 110.04382 ? 479 ALA A N     1 ? 
ATOM   3762 C CA    . ALA A 1 485 ? -13.63740 10.69658  36.79112  1.000 109.86308 ? 479 ALA A CA    1 ? 
ATOM   3763 C C     . ALA A 1 485 ? -15.05309 11.25124  36.69419  1.000 112.81074 ? 479 ALA A C     1 ? 
ATOM   3764 O O     . ALA A 1 485 ? -15.44459 11.79220  35.65324  1.000 109.97204 ? 479 ALA A O     1 ? 
ATOM   3765 C CB    . ALA A 1 485 ? -13.63262 9.19527   36.50598  1.000 102.17000 ? 479 ALA A CB    1 ? 
ATOM   3766 N N     . ASN A 1 486 ? -15.83608 11.13066  37.76673  1.000 113.69911 ? 480 ASN A N     1 ? 
ATOM   3767 C CA    . ASN A 1 486 ? -17.21457 11.60665  37.73956  1.000 107.16988 ? 480 ASN A CA    1 ? 
ATOM   3768 C C     . ASN A 1 486 ? -17.32299 13.12434  37.79411  1.000 112.09242 ? 480 ASN A C     1 ? 
ATOM   3769 O O     . ASN A 1 486 ? -18.44263 13.64798  37.76314  1.000 121.11772 ? 480 ASN A O     1 ? 
ATOM   3770 C CB    . ASN A 1 486 ? -18.00807 10.97499  38.88458  1.000 107.89744 ? 480 ASN A CB    1 ? 
ATOM   3771 C CG    . ASN A 1 486 ? -18.02441 9.45885   38.81075  1.000 120.81008 ? 480 ASN A CG    1 ? 
ATOM   3772 O OD1   . ASN A 1 486 ? -17.54316 8.86887   37.84281  1.000 114.13245 ? 480 ASN A OD1   1 ? 
ATOM   3773 N ND2   . ASN A 1 486 ? -18.58356 8.82089   39.83188  1.000 127.95399 ? 480 ASN A ND2   1 ? 
ATOM   3774 N N     . LYS A 1 487 ? -16.20169 13.83918  37.87170  1.000 107.35323 ? 481 LYS A N     1 ? 
ATOM   3775 C CA    . LYS A 1 487 ? -16.21278 15.28565  37.71579  1.000 107.28761 ? 481 LYS A CA    1 ? 
ATOM   3776 C C     . LYS A 1 487 ? -16.18597 15.69267  36.24570  1.000 107.26060 ? 481 LYS A C     1 ? 
ATOM   3777 O O     . LYS A 1 487 ? -16.47730 16.85047  35.92662  1.000 109.27225 ? 481 LYS A O     1 ? 
ATOM   3778 C CB    . LYS A 1 487 ? -15.02387 15.88799  38.48362  1.000 103.77651 ? 481 LYS A CB    1 ? 
ATOM   3779 C CG    . LYS A 1 487 ? -14.88624 17.40478  38.42946  1.000 105.83667 ? 481 LYS A CG    1 ? 
ATOM   3780 C CD    . LYS A 1 487 ? -13.48838 17.86664  38.82990  1.000 109.81476 ? 481 LYS A CD    1 ? 
ATOM   3781 C CE    . LYS A 1 487 ? -12.47391 17.59013  37.73035  1.000 115.42014 ? 481 LYS A CE    1 ? 
ATOM   3782 N NZ    . LYS A 1 487 ? -11.06510 17.73394  38.19831  1.000 129.35020 ? 481 LYS A NZ    1 ? 
ATOM   3783 N N     . THR A 1 488 ? -15.89151 14.75541  35.34759  1.000 99.30811  ? 482 THR A N     1 ? 
ATOM   3784 C CA    . THR A 1 488 ? -15.75789 15.00031  33.91919  1.000 103.68876 ? 482 THR A CA    1 ? 
ATOM   3785 C C     . THR A 1 488 ? -16.90552 14.33908  33.16544  1.000 107.50903 ? 482 THR A C     1 ? 
ATOM   3786 O O     . THR A 1 488 ? -17.62969 13.49640  33.70167  1.000 114.08181 ? 482 THR A O     1 ? 
ATOM   3787 C CB    . THR A 1 488 ? -14.41454 14.47025  33.39561  1.000 104.95177 ? 482 THR A CB    1 ? 
ATOM   3788 O OG1   . THR A 1 488 ? -14.54684 13.08932  33.03324  1.000 105.18098 ? 482 THR A OG1   1 ? 
ATOM   3789 C CG2   . THR A 1 488 ? -13.34100 14.60186  34.46096  1.000 104.06739 ? 482 THR A CG2   1 ? 
ATOM   3790 N N     . LEU A 1 489 ? -17.06865 14.72907  31.90129  1.000 101.98876 ? 483 LEU A N     1 ? 
ATOM   3791 C CA    . LEU A 1 489 ? -18.03499 14.08217  31.02435  1.000 104.84906 ? 483 LEU A CA    1 ? 
ATOM   3792 C C     . LEU A 1 489 ? -17.47084 12.84016  30.35214  1.000 111.02491 ? 483 LEU A C     1 ? 
ATOM   3793 O O     . LEU A 1 489 ? -18.11115 12.29636  29.44625  1.000 116.27572 ? 483 LEU A O     1 ? 
ATOM   3794 C CB    . LEU A 1 489 ? -18.54051 15.04705  29.94677  1.000 101.68202 ? 483 LEU A CB    1 ? 
ATOM   3795 C CG    . LEU A 1 489 ? -18.87655 16.50004  30.27334  1.000 93.00268  ? 483 LEU A CG    1 ? 
ATOM   3796 C CD1   . LEU A 1 489 ? -17.72242 17.40542  29.90799  1.000 92.08913  ? 483 LEU A CD1   1 ? 
ATOM   3797 C CD2   . LEU A 1 489 ? -20.14231 16.91901  29.56606  1.000 102.19859 ? 483 LEU A CD2   1 ? 
ATOM   3798 N N     . PHE A 1 490 ? -16.28667 12.38487  30.76467  1.000 107.71436 ? 484 PHE A N     1 ? 
ATOM   3799 C CA    . PHE A 1 490 ? -15.71791 11.17257  30.19166  1.000 112.11684 ? 484 PHE A CA    1 ? 
ATOM   3800 C C     . PHE A 1 490 ? -16.47837 9.92306   30.61014  1.000 114.91100 ? 484 PHE A C     1 ? 
ATOM   3801 O O     . PHE A 1 490 ? -16.19175 8.84016   30.08874  1.000 119.60687 ? 484 PHE A O     1 ? 
ATOM   3802 C CB    . PHE A 1 490 ? -14.24036 11.04695  30.57307  1.000 111.52960 ? 484 PHE A CB    1 ? 
ATOM   3803 C CG    . PHE A 1 490 ? -13.32027 11.89278  29.73122  1.000 114.48339 ? 484 PHE A CG    1 ? 
ATOM   3804 C CD1   . PHE A 1 490 ? -13.76685 13.07230  29.15597  1.000 116.65948 ? 484 PHE A CD1   1 ? 
ATOM   3805 C CD2   . PHE A 1 490 ? -12.01030 11.50137  29.50774  1.000 109.25110 ? 484 PHE A CD2   1 ? 
ATOM   3806 C CE1   . PHE A 1 490 ? -12.92532 13.84596  28.38144  1.000 117.98960 ? 484 PHE A CE1   1 ? 
ATOM   3807 C CE2   . PHE A 1 490 ? -11.16307 12.27221  28.73213  1.000 106.56804 ? 484 PHE A CE2   1 ? 
ATOM   3808 C CZ    . PHE A 1 490 ? -11.62175 13.44548  28.16892  1.000 110.03030 ? 484 PHE A CZ    1 ? 
ATOM   3809 N N     . ALA A 1 491 ? -17.42950 10.04903  31.53598  1.000 109.08605 ? 485 ALA A N     1 ? 
ATOM   3810 C CA    . ALA A 1 491 ? -18.36325 8.97887   31.85883  1.000 111.94202 ? 485 ALA A CA    1 ? 
ATOM   3811 C C     . ALA A 1 491 ? -19.56562 8.97834   30.92360  1.000 115.65648 ? 485 ALA A C     1 ? 
ATOM   3812 O O     . ALA A 1 491 ? -20.01262 7.91160   30.48875  1.000 113.07094 ? 485 ALA A O     1 ? 
ATOM   3813 C CB    . ALA A 1 491 ? -18.83330 9.10668   33.31079  1.000 112.77389 ? 485 ALA A CB    1 ? 
ATOM   3814 N N     . LYS A 1 492 ? -20.09779 10.16104  30.60382  1.000 115.84721 ? 486 LYS A N     1 ? 
ATOM   3815 C CA    . LYS A 1 492 ? -21.21216 10.30178  29.67418  1.000 116.67417 ? 486 LYS A CA    1 ? 
ATOM   3816 C C     . LYS A 1 492 ? -20.75535 10.41950  28.22493  1.000 116.06381 ? 486 LYS A C     1 ? 
ATOM   3817 O O     . LYS A 1 492 ? -21.42600 11.07723  27.41787  1.000 107.43157 ? 486 LYS A O     1 ? 
ATOM   3818 C CB    . LYS A 1 492 ? -22.07032 11.50860  30.05821  1.000 111.44193 ? 486 LYS A CB    1 ? 
ATOM   3819 C CG    . LYS A 1 492 ? -22.05060 11.85078  31.53903  1.000 113.18729 ? 486 LYS A CG    1 ? 
ATOM   3820 C CD    . LYS A 1 492 ? -23.25389 12.70028  31.92360  1.000 110.17943 ? 486 LYS A CD    1 ? 
ATOM   3821 C CE    . LYS A 1 492 ? -23.22418 14.05265  31.22694  1.000 110.42761 ? 486 LYS A CE    1 ? 
ATOM   3822 N NZ    . LYS A 1 492 ? -23.93748 15.10209  32.00806  1.000 102.90900 ? 486 LYS A NZ    1 ? 
ATOM   3823 N N     . ALA A 1 493 ? -19.62824 9.80318   27.87262  1.000 121.75317 ? 487 ALA A N     1 ? 
ATOM   3824 C CA    . ALA A 1 493 ? -19.12787 9.85775   26.50547  1.000 120.71824 ? 487 ALA A CA    1 ? 
ATOM   3825 C C     . ALA A 1 493 ? -18.63211 8.48971   26.05435  1.000 132.26929 ? 487 ALA A C     1 ? 
ATOM   3826 O O     . ALA A 1 493 ? -19.21452 7.46204   26.41595  1.000 130.18480 ? 487 ALA A O     1 ? 
ATOM   3827 C CB    . ALA A 1 493 ? -18.01521 10.89970  26.38237  1.000 112.91336 ? 487 ALA A CB    1 ? 
ATOM   3828 N N     . LYS A 1 494 ? -17.55277 8.46458   25.27128  1.000 137.25785 ? 488 LYS A N     1 ? 
ATOM   3829 C CA    . LYS A 1 494 ? -17.05727 7.21587   24.70672  1.000 133.67256 ? 488 LYS A CA    1 ? 
ATOM   3830 C C     . LYS A 1 494 ? -16.17803 6.42679   25.66592  1.000 138.52518 ? 488 LYS A C     1 ? 
ATOM   3831 O O     . LYS A 1 494 ? -15.89487 5.25892   25.38135  1.000 144.89192 ? 488 LYS A O     1 ? 
ATOM   3832 C CB    . LYS A 1 494 ? -16.25299 7.48008   23.43102  1.000 126.18653 ? 488 LYS A CB    1 ? 
ATOM   3833 C CG    . LYS A 1 494 ? -15.65655 8.87168   23.33067  1.000 124.01385 ? 488 LYS A CG    1 ? 
ATOM   3834 C CD    . LYS A 1 494 ? -14.89785 9.03608   22.02279  1.000 120.85553 ? 488 LYS A CD    1 ? 
ATOM   3835 C CE    . LYS A 1 494 ? -14.54857 10.48870  21.75314  1.000 112.19454 ? 488 LYS A CE    1 ? 
ATOM   3836 N NZ    . LYS A 1 494 ? -15.76367 11.33089  21.58833  1.000 101.48598 ? 488 LYS A NZ    1 ? 
ATOM   3837 N N     . CYS A 1 495 ? -15.76073 7.02823   26.78049  1.000 134.11536 ? 489 CYS A N     1 ? 
ATOM   3838 C CA    . CYS A 1 495 ? -14.69247 6.51855   27.65529  1.000 131.45012 ? 489 CYS A CA    1 ? 
ATOM   3839 C C     . CYS A 1 495 ? -13.53093 5.91609   26.86018  1.000 125.36109 ? 489 CYS A C     1 ? 
ATOM   3840 O O     . CYS A 1 495 ? -13.55962 4.75244   26.46099  1.000 128.81715 ? 489 CYS A O     1 ? 
ATOM   3841 C CB    . CYS A 1 495 ? -15.22704 5.49442   28.67451  1.000 133.34586 ? 489 CYS A CB    1 ? 
ATOM   3842 S SG    . CYS A 1 495 ? -16.20197 4.09075   28.06503  1.000 140.21794 ? 489 CYS A SG    1 ? 
ATOM   3843 N N     . VAL A 1 509 ? -10.17721 -0.84882  31.69112  1.000 131.38243 ? 503 VAL A N     1 ? 
ATOM   3844 C CA    . VAL A 1 509 ? -11.16902 0.06123   31.13523  1.000 142.70059 ? 503 VAL A CA    1 ? 
ATOM   3845 C C     . VAL A 1 509 ? -11.39647 1.20483   32.13321  1.000 141.52373 ? 503 VAL A C     1 ? 
ATOM   3846 O O     . VAL A 1 509 ? -12.46347 1.81987   32.18172  1.000 142.58946 ? 503 VAL A O     1 ? 
ATOM   3847 C CB    . VAL A 1 509 ? -12.47983 -0.70007  30.78090  1.000 140.54206 ? 503 VAL A CB    1 ? 
ATOM   3848 C CG1   . VAL A 1 509 ? -13.21123 -1.17014  32.04019  1.000 137.62385 ? 503 VAL A CG1   1 ? 
ATOM   3849 C CG2   . VAL A 1 509 ? -13.38075 0.12487   29.85385  1.000 131.26779 ? 503 VAL A CG2   1 ? 
ATOM   3850 N N     . TYR A 1 510 ? -10.36337 1.49741   32.92212  1.000 134.93743 ? 504 TYR A N     1 ? 
ATOM   3851 C CA    . TYR A 1 510 ? -10.42444 2.54716   33.92890  1.000 122.71864 ? 504 TYR A CA    1 ? 
ATOM   3852 C C     . TYR A 1 510 ? -9.11940  3.33198   33.92217  1.000 105.11546 ? 504 TYR A C     1 ? 
ATOM   3853 O O     . TYR A 1 510 ? -8.07728  2.84052   33.48135  1.000 97.04778  ? 504 TYR A O     1 ? 
ATOM   3854 C CB    . TYR A 1 510 ? -10.69227 1.97066   35.32529  1.000 125.32912 ? 504 TYR A CB    1 ? 
ATOM   3855 C CG    . TYR A 1 510 ? -12.07438 2.27009   35.85804  1.000 126.52426 ? 504 TYR A CG    1 ? 
ATOM   3856 C CD1   . TYR A 1 510 ? -13.20608 1.77400   35.22420  1.000 132.34313 ? 504 TYR A CD1   1 ? 
ATOM   3857 C CD2   . TYR A 1 510 ? -12.24773 3.04657   36.99593  1.000 115.14757 ? 504 TYR A CD2   1 ? 
ATOM   3858 C CE1   . TYR A 1 510 ? -14.47162 2.04411   35.70670  1.000 133.31742 ? 504 TYR A CE1   1 ? 
ATOM   3859 C CE2   . TYR A 1 510 ? -13.50944 3.32209   37.48669  1.000 121.96066 ? 504 TYR A CE2   1 ? 
ATOM   3860 C CZ    . TYR A 1 510 ? -14.61760 2.81831   36.83821  1.000 140.96255 ? 504 TYR A CZ    1 ? 
ATOM   3861 O OH    . TYR A 1 510 ? -15.87634 3.08960   37.32280  1.000 147.79517 ? 504 TYR A OH    1 ? 
ATOM   3862 N N     . LEU A 1 511 ? -9.18691  4.56472   34.42411  1.000 103.28326 ? 505 LEU A N     1 ? 
ATOM   3863 C CA    . LEU A 1 511 ? -8.03102  5.45028   34.43122  1.000 92.30476  ? 505 LEU A CA    1 ? 
ATOM   3864 C C     . LEU A 1 511 ? -8.08098  6.35890   35.65068  1.000 89.16171  ? 505 LEU A C     1 ? 
ATOM   3865 O O     . LEU A 1 511 ? -9.13991  6.58688   36.24179  1.000 90.79925  ? 505 LEU A O     1 ? 
ATOM   3866 C CB    . LEU A 1 511 ? -7.96155  6.30546   33.15881  1.000 92.59009  ? 505 LEU A CB    1 ? 
ATOM   3867 C CG    . LEU A 1 511 ? -7.52704  5.64077   31.85265  1.000 90.49214  ? 505 LEU A CG    1 ? 
ATOM   3868 C CD1   . LEU A 1 511 ? -8.38324  6.13460   30.69750  1.000 91.61646  ? 505 LEU A CD1   1 ? 
ATOM   3869 C CD2   . LEU A 1 511 ? -6.05436  5.90632   31.58470  1.000 81.78369  ? 505 LEU A CD2   1 ? 
ATOM   3870 N N     . TYR A 1 512 ? -6.91115  6.87696   36.01619  1.000 85.84479  ? 506 TYR A N     1 ? 
ATOM   3871 C CA    . TYR A 1 512 ? -6.78272  7.93274   37.01155  1.000 82.70741  ? 506 TYR A CA    1 ? 
ATOM   3872 C C     . TYR A 1 512 ? -6.60120  9.25651   36.28156  1.000 79.84045  ? 506 TYR A C     1 ? 
ATOM   3873 O O     . TYR A 1 512 ? -5.71155  9.38426   35.43423  1.000 77.67648  ? 506 TYR A O     1 ? 
ATOM   3874 C CB    . TYR A 1 512 ? -5.60247  7.66303   37.94840  1.000 84.20557  ? 506 TYR A CB    1 ? 
ATOM   3875 C CG    . TYR A 1 512 ? -5.20955  8.83517   38.82383  1.000 84.61754  ? 506 TYR A CG    1 ? 
ATOM   3876 C CD1   . TYR A 1 512 ? -5.82693  9.04874   40.04963  1.000 83.87249  ? 506 TYR A CD1   1 ? 
ATOM   3877 C CD2   . TYR A 1 512 ? -4.20656  9.71533   38.43426  1.000 90.45876  ? 506 TYR A CD2   1 ? 
ATOM   3878 C CE1   . TYR A 1 512 ? -5.46805  10.11382  40.85507  1.000 87.69702  ? 506 TYR A CE1   1 ? 
ATOM   3879 C CE2   . TYR A 1 512 ? -3.84155  10.78274  39.23288  1.000 90.98356  ? 506 TYR A CE2   1 ? 
ATOM   3880 C CZ    . TYR A 1 512 ? -4.47510  10.97714  40.44177  1.000 88.90856  ? 506 TYR A CZ    1 ? 
ATOM   3881 O OH    . TYR A 1 512 ? -4.11384  12.03777  41.24039  1.000 81.75079  ? 506 TYR A OH    1 ? 
ATOM   3882 N N     . MET A 1 513 ? -7.44469  10.23575  36.60413  1.000 83.14486  ? 507 MET A N     1 ? 
ATOM   3883 C CA    . MET A 1 513 ? -7.51192  11.47635  35.84100  1.000 77.77965  ? 507 MET A CA    1 ? 
ATOM   3884 C C     . MET A 1 513 ? -7.15990  12.69523  36.68843  1.000 80.17128  ? 507 MET A C     1 ? 
ATOM   3885 O O     . MET A 1 513 ? -7.71215  13.77887  36.48899  1.000 77.39274  ? 507 MET A O     1 ? 
ATOM   3886 C CB    . MET A 1 513 ? -8.89499  11.63697  35.21295  1.000 76.80864  ? 507 MET A CB    1 ? 
ATOM   3887 C CG    . MET A 1 513 ? -9.21008  10.57880  34.16781  1.000 84.21765  ? 507 MET A CG    1 ? 
ATOM   3888 S SD    . MET A 1 513 ? -10.52611 11.06154  33.03643  1.000 113.18363 ? 507 MET A SD    1 ? 
ATOM   3889 C CE    . MET A 1 513 ? -11.56332 9.60250   33.09349  1.000 94.72291  ? 507 MET A CE    1 ? 
ATOM   3890 N N     . GLY A 1 514 ? -6.23439  12.53581  37.63205  1.000 85.10359  ? 508 GLY A N     1 ? 
ATOM   3891 C CA    . GLY A 1 514 ? -5.76554  13.65749  38.41918  1.000 87.31550  ? 508 GLY A CA    1 ? 
ATOM   3892 C C     . GLY A 1 514 ? -4.57639  14.39088  37.84802  1.000 86.64989  ? 508 GLY A C     1 ? 
ATOM   3893 O O     . GLY A 1 514 ? -4.19351  15.43991  38.37398  1.000 98.68347  ? 508 GLY A O     1 ? 
ATOM   3894 N N     . GLY A 1 515 ? -3.98272  13.87009  36.78040  1.000 79.06395  ? 509 GLY A N     1 ? 
ATOM   3895 C CA    . GLY A 1 515 ? -2.81283  14.46585  36.17149  1.000 78.87208  ? 509 GLY A CA    1 ? 
ATOM   3896 C C     . GLY A 1 515 ? -1.52654  13.79120  36.61737  1.000 83.30394  ? 509 GLY A C     1 ? 
ATOM   3897 O O     . GLY A 1 515 ? -1.47789  13.03595  37.59146  1.000 80.11667  ? 509 GLY A O     1 ? 
ATOM   3898 N N     . LEU A 1 516 ? -0.45798  14.08149  35.87089  1.000 77.88728  ? 510 LEU A N     1 ? 
ATOM   3899 C CA    . LEU A 1 516 ? 0.84220   13.49770  36.18598  1.000 69.06847  ? 510 LEU A CA    1 ? 
ATOM   3900 C C     . LEU A 1 516 ? 1.38775   14.03435  37.50339  1.000 81.69193  ? 510 LEU A C     1 ? 
ATOM   3901 O O     . LEU A 1 516 ? 1.95610   13.27738  38.29941  1.000 88.49198  ? 510 LEU A O     1 ? 
ATOM   3902 C CB    . LEU A 1 516 ? 1.82951   13.76638  35.05075  1.000 68.30725  ? 510 LEU A CB    1 ? 
ATOM   3903 C CG    . LEU A 1 516 ? 3.21479   13.13501  35.20799  1.000 65.67667  ? 510 LEU A CG    1 ? 
ATOM   3904 C CD1   . LEU A 1 516 ? 3.12499   11.61685  35.17242  1.000 68.42713  ? 510 LEU A CD1   1 ? 
ATOM   3905 C CD2   . LEU A 1 516 ? 4.16811   13.64778  34.14008  1.000 62.17507  ? 510 LEU A CD2   1 ? 
ATOM   3906 N N     . LYS A 1 517 ? 1.22701   15.33687  37.74958  1.000 84.08423  ? 511 LYS A N     1 ? 
ATOM   3907 C CA    . LYS A 1 517 ? 1.74157   15.93038  38.98025  1.000 82.19398  ? 511 LYS A CA    1 ? 
ATOM   3908 C C     . LYS A 1 517 ? 1.04789   15.34598  40.20425  1.000 85.53600  ? 511 LYS A C     1 ? 
ATOM   3909 O O     . LYS A 1 517 ? 1.70438   14.94432  41.17217  1.000 81.77009  ? 511 LYS A O     1 ? 
ATOM   3910 C CB    . LYS A 1 517 ? 1.57458   17.44934  38.93974  1.000 82.98227  ? 511 LYS A CB    1 ? 
ATOM   3911 C CG    . LYS A 1 517 ? 2.45298   18.19433  39.93205  1.000 98.75001  ? 511 LYS A CG    1 ? 
ATOM   3912 C CD    . LYS A 1 517 ? 2.23935   19.69583  39.83840  1.000 91.84139  ? 511 LYS A CD    1 ? 
ATOM   3913 C CE    . LYS A 1 517 ? 2.31050   20.35380  41.20558  1.000 91.88735  ? 511 LYS A CE    1 ? 
ATOM   3914 N NZ    . LYS A 1 517 ? 1.20594   21.33255  41.40335  1.000 106.10317 ? 511 LYS A NZ    1 ? 
ATOM   3915 N N     . GLU A 1 518 ? -0.28632  15.29246  40.17959  1.000 87.22410  ? 512 GLU A N     1 ? 
ATOM   3916 C CA    . GLU A 1 518 ? -1.01903  14.70482  41.29565  1.000 84.04394  ? 512 GLU A CA    1 ? 
ATOM   3917 C C     . GLU A 1 518 ? -0.71829  13.21930  41.43973  1.000 87.30530  ? 512 GLU A C     1 ? 
ATOM   3918 O O     . GLU A 1 518 ? -0.69689  12.69672  42.55995  1.000 87.03891  ? 512 GLU A O     1 ? 
ATOM   3919 C CB    . GLU A 1 518 ? -2.52057  14.93049  41.11718  1.000 82.41776  ? 512 GLU A CB    1 ? 
ATOM   3920 C CG    . GLU A 1 518 ? -2.97793  16.35035  41.41732  1.000 102.63629 ? 512 GLU A CG    1 ? 
ATOM   3921 C CD    . GLU A 1 518 ? -2.40629  16.88842  42.71552  1.000 114.86819 ? 512 GLU A CD    1 ? 
ATOM   3922 O OE1   . GLU A 1 518 ? -2.58411  16.23219  43.76366  1.000 120.77701 ? 512 GLU A OE1   1 ? 
ATOM   3923 O OE2   . GLU A 1 518 ? -1.77947  17.96871  42.68790  1.000 105.59583 ? 512 GLU A OE2   1 ? 
ATOM   3924 N N     . TYR A 1 519 ? -0.48209  12.52469  40.32398  1.000 86.65434  ? 513 TYR A N     1 ? 
ATOM   3925 C CA    . TYR A 1 519 ? -0.10786  11.11653  40.39895  1.000 84.30641  ? 513 TYR A CA    1 ? 
ATOM   3926 C C     . TYR A 1 519 ? 1.27846   10.94888  41.00676  1.000 83.49965  ? 513 TYR A C     1 ? 
ATOM   3927 O O     . TYR A 1 519 ? 1.51168   10.01923  41.78857  1.000 84.01404  ? 513 TYR A O     1 ? 
ATOM   3928 C CB    . TYR A 1 519 ? -0.16576  10.48094  39.01020  1.000 80.73591  ? 513 TYR A CB    1 ? 
ATOM   3929 C CG    . TYR A 1 519 ? 0.15207   9.00368   39.00262  1.000 79.27703  ? 513 TYR A CG    1 ? 
ATOM   3930 C CD1   . TYR A 1 519 ? -0.79292  8.06868   39.40364  1.000 84.60400  ? 513 TYR A CD1   1 ? 
ATOM   3931 C CD2   . TYR A 1 519 ? 1.39900   8.54400   38.59884  1.000 68.64150  ? 513 TYR A CD2   1 ? 
ATOM   3932 C CE1   . TYR A 1 519 ? -0.50636  6.71687   39.40043  1.000 79.60342  ? 513 TYR A CE1   1 ? 
ATOM   3933 C CE2   . TYR A 1 519 ? 1.69506   7.19459   38.59272  1.000 75.03734  ? 513 TYR A CE2   1 ? 
ATOM   3934 C CZ    . TYR A 1 519 ? 0.73862   6.28562   38.99424  1.000 77.54983  ? 513 TYR A CZ    1 ? 
ATOM   3935 O OH    . TYR A 1 519 ? 1.02809   4.94063   38.98951  1.000 78.73247  ? 513 TYR A OH    1 ? 
ATOM   3936 N N     . ARG A 1 520 ? 2.21217   11.83728  40.65577  1.000 80.36837  ? 514 ARG A N     1 ? 
ATOM   3937 C CA    . ARG A 1 520 ? 3.54239   11.78562  41.25146  1.000 78.14663  ? 514 ARG A CA    1 ? 
ATOM   3938 C C     . ARG A 1 520 ? 3.49089   12.05422  42.74899  1.000 88.09883  ? 514 ARG A C     1 ? 
ATOM   3939 O O     . ARG A 1 520 ? 4.27980   11.48303  43.51010  1.000 89.11939  ? 514 ARG A O     1 ? 
ATOM   3940 C CB    . ARG A 1 520 ? 4.46532   12.79084  40.56100  1.000 77.89359  ? 514 ARG A CB    1 ? 
ATOM   3941 C CG    . ARG A 1 520 ? 5.13092   12.26325  39.30049  1.000 78.98405  ? 514 ARG A CG    1 ? 
ATOM   3942 C CD    . ARG A 1 520 ? 6.29168   13.14827  38.87483  1.000 83.52881  ? 514 ARG A CD    1 ? 
ATOM   3943 N NE    . ARG A 1 520 ? 7.55813   12.42534  38.86378  1.000 92.59452  ? 514 ARG A NE    1 ? 
ATOM   3944 C CZ    . ARG A 1 520 ? 8.73586   12.97144  39.13546  1.000 98.74506  ? 514 ARG A CZ    1 ? 
ATOM   3945 N NH1   . ARG A 1 520 ? 8.84861   14.25183  39.44960  1.000 96.49295  ? 514 ARG A NH1   1 ? 
ATOM   3946 N NH2   . ARG A 1 520 ? 9.82833   12.21406  39.08990  1.000 102.67753 ? 514 ARG A NH2   1 ? 
ATOM   3947 N N     . ASN A 1 521 ? 2.56972   12.91404  43.18969  1.000 87.50339  ? 515 ASN A N     1 ? 
ATOM   3948 C CA    . ASN A 1 521 ? 2.43274   13.18676  44.61631  1.000 90.88237  ? 515 ASN A CA    1 ? 
ATOM   3949 C C     . ASN A 1 521 ? 1.76591   12.02388  45.33941  1.000 93.68967  ? 515 ASN A C     1 ? 
ATOM   3950 O O     . ASN A 1 521 ? 2.15592   11.67778  46.46084  1.000 96.69302  ? 515 ASN A O     1 ? 
ATOM   3951 C CB    . ASN A 1 521 ? 1.63410   14.47268  44.83092  1.000 89.72397  ? 515 ASN A CB    1 ? 
ATOM   3952 C CG    . ASN A 1 521 ? 2.45477   15.72050  44.57777  1.000 101.36727 ? 515 ASN A CG    1 ? 
ATOM   3953 O OD1   . ASN A 1 521 ? 3.68079   15.70666  44.68847  1.000 99.05989  ? 515 ASN A OD1   1 ? 
ATOM   3954 N ND2   . ASN A 1 521 ? 1.77888   16.81126  44.23619  1.000 105.08566 ? 515 ASN A ND2   1 ? 
ATOM   3955 N N     . GLN A 1 522 ? 0.75847   11.41010  44.71214  1.000 89.52016  ? 516 GLN A N     1 ? 
ATOM   3956 C CA    . GLN A 1 522 ? 0.00939   10.34437  45.37106  1.000 87.24580  ? 516 GLN A CA    1 ? 
ATOM   3957 C C     . GLN A 1 522 ? 0.89732   9.14392   45.67237  1.000 91.18870  ? 516 GLN A C     1 ? 
ATOM   3958 O O     . GLN A 1 522 ? 0.84272   8.58384   46.77362  1.000 91.68641  ? 516 GLN A O     1 ? 
ATOM   3959 C CB    . GLN A 1 522 ? -1.18067  9.92798   44.50622  1.000 87.86972  ? 516 GLN A CB    1 ? 
ATOM   3960 C CG    . GLN A 1 522 ? -2.38675  10.85045  44.61649  1.000 88.25063  ? 516 GLN A CG    1 ? 
ATOM   3961 C CD    . GLN A 1 522 ? -3.25828  10.54058  45.81886  1.000 94.68369  ? 516 GLN A CD    1 ? 
ATOM   3962 O OE1   . GLN A 1 522 ? -2.89330  9.73587   46.67600  1.000 97.16555  ? 516 GLN A OE1   1 ? 
ATOM   3963 N NE2   . GLN A 1 522 ? -4.41965  11.18146  45.88719  1.000 101.10055 ? 516 GLN A NE2   1 ? 
ATOM   3964 N N     . ILE A 1 523 ? 1.72360   8.73205   44.70745  1.000 90.02088  ? 517 ILE A N     1 ? 
ATOM   3965 C CA    . ILE A 1 523 ? 2.62886   7.61619   44.94844  1.000 87.55739  ? 517 ILE A CA    1 ? 
ATOM   3966 C C     . ILE A 1 523 ? 3.78655   8.02342   45.84907  1.000 93.48229  ? 517 ILE A C     1 ? 
ATOM   3967 O O     . ILE A 1 523 ? 4.40535   7.16141   46.48386  1.000 91.11142  ? 517 ILE A O     1 ? 
ATOM   3968 C CB    . ILE A 1 523 ? 3.14452   7.03546   43.61872  1.000 75.83301  ? 517 ILE A CB    1 ? 
ATOM   3969 C CG1   . ILE A 1 523 ? 3.99357   8.06493   42.87328  1.000 79.93013  ? 517 ILE A CG1   1 ? 
ATOM   3970 C CG2   . ILE A 1 523 ? 1.98117   6.57458   42.75419  1.000 79.95689  ? 517 ILE A CG2   1 ? 
ATOM   3971 C CD1   . ILE A 1 523 ? 4.70586   7.49885   41.66903  1.000 76.90232  ? 517 ILE A CD1   1 ? 
ATOM   3972 N N     . SER A 1 524 ? 4.10039   9.31961   45.92205  1.000 105.31620 ? 518 SER A N     1 ? 
ATOM   3973 C CA    . SER A 1 524 ? 5.08443   9.78224   46.89483  1.000 96.16192  ? 518 SER A CA    1 ? 
ATOM   3974 C C     . SER A 1 524 ? 4.50397   9.76607   48.30243  1.000 101.13452 ? 518 SER A C     1 ? 
ATOM   3975 O O     . SER A 1 524 ? 5.21636   9.47996   49.27168  1.000 100.97826 ? 518 SER A O     1 ? 
ATOM   3976 C CB    . SER A 1 524 ? 5.57297   11.18303  46.52817  1.000 92.48068  ? 518 SER A CB    1 ? 
ATOM   3977 O OG    . SER A 1 524 ? 6.29736   11.16774  45.31061  1.000 98.61217  ? 518 SER A OG    1 ? 
ATOM   3978 N N     . GLU A 1 525 ? 3.20924   10.07097  48.43145  1.000 101.03178 ? 519 GLU A N     1 ? 
ATOM   3979 C CA    . GLU A 1 525 ? 2.53276   9.93203   49.71658  1.000 100.07753 ? 519 GLU A CA    1 ? 
ATOM   3980 C C     . GLU A 1 525 ? 2.57219   8.49208   50.21012  1.000 101.97927 ? 519 GLU A C     1 ? 
ATOM   3981 O O     . GLU A 1 525 ? 2.51567   8.24668   51.42040  1.000 101.47661 ? 519 GLU A O     1 ? 
ATOM   3982 C CB    . GLU A 1 525 ? 1.08665   10.41670  49.59658  1.000 103.80801 ? 519 GLU A CB    1 ? 
ATOM   3983 C CG    . GLU A 1 525 ? 0.34599   10.55484  50.91702  1.000 107.45372 ? 519 GLU A CG    1 ? 
ATOM   3984 C CD    . GLU A 1 525 ? -0.87660  11.44651  50.80521  1.000 120.24177 ? 519 GLU A CD    1 ? 
ATOM   3985 O OE1   . GLU A 1 525 ? -1.81459  11.27781  51.61257  1.000 119.22071 ? 519 GLU A OE1   1 ? 
ATOM   3986 O OE2   . GLU A 1 525 ? -0.89979  12.31673  49.90927  1.000 118.26780 ? 519 GLU A OE2   1 ? 
ATOM   3987 N N     . VAL A 1 526 ? 2.67232   7.53110   49.29227  1.000 100.19648 ? 520 VAL A N     1 ? 
ATOM   3988 C CA    . VAL A 1 526 ? 2.77637   6.12963   49.68084  1.000 91.97582  ? 520 VAL A CA    1 ? 
ATOM   3989 C C     . VAL A 1 526 ? 4.21606   5.77586   50.03215  1.000 94.49293  ? 520 VAL A C     1 ? 
ATOM   3990 O O     . VAL A 1 526 ? 4.48923   5.21027   51.09646  1.000 103.41097 ? 520 VAL A O     1 ? 
ATOM   3991 C CB    . VAL A 1 526 ? 2.22676   5.22598   48.56092  1.000 95.60653  ? 520 VAL A CB    1 ? 
ATOM   3992 C CG1   . VAL A 1 526 ? 2.71976   3.79644   48.73488  1.000 100.08802 ? 520 VAL A CG1   1 ? 
ATOM   3993 C CG2   . VAL A 1 526 ? 0.70573   5.27601   48.53678  1.000 90.12350  ? 520 VAL A CG2   1 ? 
ATOM   3994 N N     . SER A 1 527 ? 5.16153   6.11880   49.15340  1.000 94.95286  ? 521 SER A N     1 ? 
ATOM   3995 C CA    . SER A 1 527 ? 6.56179   5.77611   49.37708  1.000 93.54304  ? 521 SER A CA    1 ? 
ATOM   3996 C C     . SER A 1 527 ? 7.19327   6.55715   50.52283  1.000 97.75883  ? 521 SER A C     1 ? 
ATOM   3997 O O     . SER A 1 527 ? 8.31875   6.23493   50.91809  1.000 96.73714  ? 521 SER A O     1 ? 
ATOM   3998 C CB    . SER A 1 527 ? 7.36971   5.99737   48.09655  1.000 91.27345  ? 521 SER A CB    1 ? 
ATOM   3999 O OG    . SER A 1 527 ? 7.06784   7.25032   47.50936  1.000 100.34367 ? 521 SER A OG    1 ? 
ATOM   4000 N N     . ASN A 1 528 ? 6.51149   7.57002   51.05803  1.000 99.65006  ? 522 ASN A N     1 ? 
ATOM   4001 C CA    . ASN A 1 528 ? 7.00800   8.28623   52.22695  1.000 97.82017  ? 522 ASN A CA    1 ? 
ATOM   4002 C C     . ASN A 1 528 ? 6.44397   7.72292   53.52487  1.000 98.85081  ? 522 ASN A C     1 ? 
ATOM   4003 O O     . ASN A 1 528 ? 7.16512   7.62991   54.52415  1.000 91.81953  ? 522 ASN A O     1 ? 
ATOM   4004 C CB    . ASN A 1 528 ? 6.67425   9.77663   52.12034  1.000 96.47264  ? 522 ASN A CB    1 ? 
ATOM   4005 C CG    . ASN A 1 528 ? 7.52208   10.49128  51.08755  1.000 99.93174  ? 522 ASN A CG    1 ? 
ATOM   4006 O OD1   . ASN A 1 528 ? 8.73250   10.28142  51.00815  1.000 102.55227 ? 522 ASN A OD1   1 ? 
ATOM   4007 N ND2   . ASN A 1 528 ? 6.88894   11.34295  50.28898  1.000 97.07567  ? 522 ASN A ND2   1 ? 
ATOM   4008 N N     . ASN A 1 529 ? 5.16773   7.33997   53.52769  1.000 101.28431 ? 523 ASN A N     1 ? 
ATOM   4009 C CA    . ASN A 1 529 ? 4.52435   6.75692   54.70461  1.000 100.06821 ? 523 ASN A CA    1 ? 
ATOM   4010 C C     . ASN A 1 529 ? 4.82779   5.27225   54.86988  1.000 97.01980  ? 523 ASN A C     1 ? 
ATOM   4011 O O     . ASN A 1 529 ? 3.95285   4.49812   55.26685  1.000 95.87848  ? 523 ASN A O     1 ? 
ATOM   4012 C CB    . ASN A 1 529 ? 3.01791   6.99670   54.62912  1.000 100.52043 ? 523 ASN A CB    1 ? 
ATOM   4013 C CG    . ASN A 1 529 ? 2.66744   8.46378   54.46697  1.000 108.62430 ? 523 ASN A CG    1 ? 
ATOM   4014 O OD1   . ASN A 1 529 ? 3.51895   9.28371   54.12259  1.000 110.82669 ? 523 ASN A OD1   1 ? 
ATOM   4015 N ND2   . ASN A 1 529 ? 1.40689   8.80161   54.71436  1.000 94.80288  ? 523 ASN A ND2   1 ? 
ATOM   4016 N N     . ASN A 1 530 ? 6.06149   4.86004   54.56713  1.000 95.78421  ? 524 ASN A N     1 ? 
ATOM   4017 C CA    . ASN A 1 530 ? 6.50041   3.46946   54.70465  1.000 101.57321 ? 524 ASN A CA    1 ? 
ATOM   4018 C C     . ASN A 1 530 ? 5.59945   2.51748   53.92084  1.000 103.76918 ? 524 ASN A C     1 ? 
ATOM   4019 O O     . ASN A 1 530 ? 5.28923   1.41362   54.37397  1.000 110.61607 ? 524 ASN A O     1 ? 
ATOM   4020 C CB    . ASN A 1 530 ? 6.58411   3.05678   56.17619  1.000 99.51757  ? 524 ASN A CB    1 ? 
ATOM   4021 C CG    . ASN A 1 530 ? 7.99954   2.72469   56.60627  1.000 104.42667 ? 524 ASN A CG    1 ? 
ATOM   4022 O OD1   . ASN A 1 530 ? 8.77810   2.16176   55.83615  1.000 106.12640 ? 524 ASN A OD1   1 ? 
ATOM   4023 N ND2   . ASN A 1 530 ? 8.34253   3.07857   57.84006  1.000 91.54498  ? 524 ASN A ND2   1 ? 
ATOM   4024 N N     . TYR A 1 531 ? 5.17161   2.95851   52.73668  1.000 99.77961  ? 525 TYR A N     1 ? 
ATOM   4025 C CA    . TYR A 1 531 ? 4.37463   2.15070   51.81303  1.000 100.90756 ? 525 TYR A CA    1 ? 
ATOM   4026 C C     . TYR A 1 531 ? 3.05582   1.71455   52.45568  1.000 98.79661  ? 525 TYR A C     1 ? 
ATOM   4027 O O     . TYR A 1 531 ? 2.75398   0.52720   52.59266  1.000 97.50312  ? 525 TYR A O     1 ? 
ATOM   4028 C CB    . TYR A 1 531 ? 5.18573   0.95378   51.30694  1.000 90.10992  ? 525 TYR A CB    1 ? 
ATOM   4029 C CG    . TYR A 1 531 ? 6.34172   1.37434   50.43005  1.000 91.11222  ? 525 TYR A CG    1 ? 
ATOM   4030 C CD1   . TYR A 1 531 ? 6.11884   1.93916   49.18146  1.000 94.88903  ? 525 TYR A CD1   1 ? 
ATOM   4031 C CD2   . TYR A 1 531 ? 7.65367   1.24260   50.86513  1.000 89.15427  ? 525 TYR A CD2   1 ? 
ATOM   4032 C CE1   . TYR A 1 531 ? 7.16986   2.33705   48.37937  1.000 90.69122  ? 525 TYR A CE1   1 ? 
ATOM   4033 C CE2   . TYR A 1 531 ? 8.71207   1.64120   50.07162  1.000 89.47287  ? 525 TYR A CE2   1 ? 
ATOM   4034 C CZ    . TYR A 1 531 ? 8.46407   2.18667   48.82917  1.000 84.57137  ? 525 TYR A CZ    1 ? 
ATOM   4035 O OH    . TYR A 1 531 ? 9.51408   2.58420   48.03407  1.000 83.12777  ? 525 TYR A OH    1 ? 
ATOM   4036 N N     . LYS A 1 532 ? 2.27157   2.71594   52.85102  1.000 100.39236 ? 526 LYS A N     1 ? 
ATOM   4037 C CA    . LYS A 1 532 ? 0.94437   2.47080   53.39842  1.000 99.26868  ? 526 LYS A CA    1 ? 
ATOM   4038 C C     . LYS A 1 532 ? 0.07099   1.76919   52.36702  1.000 98.16221  ? 526 LYS A C     1 ? 
ATOM   4039 O O     . LYS A 1 532 ? 0.05256   2.14504   51.19156  1.000 110.82752 ? 526 LYS A O     1 ? 
ATOM   4040 C CB    . LYS A 1 532 ? 0.30739   3.79260   53.82995  1.000 98.39397  ? 526 LYS A CB    1 ? 
ATOM   4041 C CG    . LYS A 1 532 ? -1.18407  3.71738   54.11417  1.000 103.90773 ? 526 LYS A CG    1 ? 
ATOM   4042 C CD    . LYS A 1 532 ? -1.98303  4.46044   53.05222  1.000 107.72884 ? 526 LYS A CD    1 ? 
ATOM   4043 C CE    . LYS A 1 532 ? -1.60903  5.93420   53.00817  1.000 107.88901 ? 526 LYS A CE    1 ? 
ATOM   4044 N NZ    . LYS A 1 532 ? -2.57271  6.73038   52.19807  1.000 112.59328 ? 526 LYS A NZ    1 ? 
ATOM   4045 N N     . GLY A 1 533 ? -0.65314  0.74502   52.81055  1.000 94.52089  ? 527 GLY A N     1 ? 
ATOM   4046 C CA    . GLY A 1 533 ? -1.46966  -0.05008  51.92178  1.000 97.25196  ? 527 GLY A CA    1 ? 
ATOM   4047 C C     . GLY A 1 533 ? -0.76031  -1.22457  51.28766  1.000 94.02513  ? 527 GLY A C     1 ? 
ATOM   4048 O O     . GLY A 1 533 ? -1.33822  -1.87354  50.40644  1.000 98.00098  ? 527 GLY A O     1 ? 
ATOM   4049 N N     . CYS A 1 534 ? 0.47053   -1.51557  51.69899  1.000 90.49247  ? 528 CYS A N     1 ? 
ATOM   4050 C CA    . CYS A 1 534 ? 1.23001   -2.64825  51.19277  1.000 98.25365  ? 528 CYS A CA    1 ? 
ATOM   4051 C C     . CYS A 1 534 ? 1.59863   -3.57028  52.34533  1.000 100.68692 ? 528 CYS A C     1 ? 
ATOM   4052 O O     . CYS A 1 534 ? 1.99679   -3.10828  53.41935  1.000 107.37864 ? 528 CYS A O     1 ? 
ATOM   4053 C CB    . CYS A 1 534 ? 2.50087   -2.18958  50.46736  1.000 99.23849  ? 528 CYS A CB    1 ? 
ATOM   4054 S SG    . CYS A 1 534 ? 2.22456   -0.95908  49.17412  1.000 105.06056 ? 528 CYS A SG    1 ? 
ATOM   4055 N N     . LEU A 1 535 ? 1.45789   -4.87340  52.12080  1.000 98.92457  ? 529 LEU A N     1 ? 
ATOM   4056 C CA    . LEU A 1 535 ? 1.87905   -5.86959  53.09424  1.000 96.55084  ? 529 LEU A CA    1 ? 
ATOM   4057 C C     . LEU A 1 535 ? 3.35964   -6.17114  52.91094  1.000 101.68474 ? 529 LEU A C     1 ? 
ATOM   4058 O O     . LEU A 1 535 ? 3.83425   -6.35905  51.78688  1.000 107.15065 ? 529 LEU A O     1 ? 
ATOM   4059 C CB    . LEU A 1 535 ? 1.05595   -7.15070  52.95661  1.000 101.35121 ? 529 LEU A CB    1 ? 
ATOM   4060 C CG    . LEU A 1 535 ? -0.46236  -6.96737  52.94221  1.000 101.02597 ? 529 LEU A CG    1 ? 
ATOM   4061 C CD1   . LEU A 1 535 ? -1.15898  -8.28685  52.65402  1.000 102.35748 ? 529 LEU A CD1   1 ? 
ATOM   4062 C CD2   . LEU A 1 535 ? -0.94024  -6.38146  54.26226  1.000 95.58900  ? 529 LEU A CD2   1 ? 
ATOM   4063 N N     . LEU A 1 536 ? 4.08815   -6.20748  54.02478  1.000 103.40880 ? 530 LEU A N     1 ? 
ATOM   4064 C CA    . LEU A 1 536 ? 5.54279   -6.33050  54.01372  1.000 102.18852 ? 530 LEU A CA    1 ? 
ATOM   4065 C C     . LEU A 1 536 ? 5.94263   -7.51294  54.88791  1.000 109.50113 ? 530 LEU A C     1 ? 
ATOM   4066 O O     . LEU A 1 536 ? 5.89030   -7.42301  56.11870  1.000 118.26487 ? 530 LEU A O     1 ? 
ATOM   4067 C CB    . LEU A 1 536 ? 6.20102   -5.03622  54.50072  1.000 105.95289 ? 530 LEU A CB    1 ? 
ATOM   4068 C CG    . LEU A 1 536 ? 6.63375   -4.00496  53.45012  1.000 102.94361 ? 530 LEU A CG    1 ? 
ATOM   4069 C CD1   . LEU A 1 536 ? 5.47111   -3.55220  52.57476  1.000 91.23804  ? 530 LEU A CD1   1 ? 
ATOM   4070 C CD2   . LEU A 1 536 ? 7.30102   -2.80982  54.11414  1.000 91.46575  ? 530 LEU A CD2   1 ? 
ATOM   4071 N N     . LYS A 1 537 ? 6.34891   -8.61229  54.25539  1.000 111.11052 ? 531 LYS A N     1 ? 
ATOM   4072 C CA    . LYS A 1 537 ? 6.67678   -9.85103  54.94964  1.000 107.27015 ? 531 LYS A CA    1 ? 
ATOM   4073 C C     . LYS A 1 537 ? 8.18707   -10.03460 55.03401  1.000 109.99542 ? 531 LYS A C     1 ? 
ATOM   4074 O O     . LYS A 1 537 ? 8.91050   -9.76741  54.07071  1.000 102.30968 ? 531 LYS A O     1 ? 
ATOM   4075 C CB    . LYS A 1 537 ? 6.05045   -11.05300 54.23930  1.000 104.37043 ? 531 LYS A CB    1 ? 
ATOM   4076 C CG    . LYS A 1 537 ? 4.80659   -10.72194 53.43077  1.000 108.02786 ? 531 LYS A CG    1 ? 
ATOM   4077 C CD    . LYS A 1 537 ? 3.56890   -10.65942 54.30749  1.000 110.26157 ? 531 LYS A CD    1 ? 
ATOM   4078 C CE    . LYS A 1 537 ? 2.30287   -10.68216 53.46647  1.000 111.70559 ? 531 LYS A CE    1 ? 
ATOM   4079 N NZ    . LYS A 1 537 ? 1.25677   -11.55905 54.06042  1.000 108.47354 ? 531 LYS A NZ    1 ? 
ATOM   4080 N N     . GLN A 1 538 ? 8.65518   -10.51029 56.18462  1.000 117.50251 ? 532 GLN A N     1 ? 
ATOM   4081 C CA    . GLN A 1 538 ? 10.07579  -10.67916 56.44882  1.000 114.35692 ? 532 GLN A CA    1 ? 
ATOM   4082 C C     . GLN A 1 538 ? 10.43521  -12.15518 56.56907  1.000 119.89717 ? 532 GLN A C     1 ? 
ATOM   4083 O O     . GLN A 1 538 ? 9.58639   -13.00890 56.84101  1.000 117.54396 ? 532 GLN A O     1 ? 
ATOM   4084 C CB    . GLN A 1 538 ? 10.48594  -9.94248  57.72884  1.000 112.64635 ? 532 GLN A CB    1 ? 
ATOM   4085 C CG    . GLN A 1 538 ? 9.86746   -8.56509  57.87546  1.000 111.20509 ? 532 GLN A CG    1 ? 
ATOM   4086 C CD    . GLN A 1 538 ? 10.90685  -7.47443  58.03931  1.000 117.74494 ? 532 GLN A CD    1 ? 
ATOM   4087 O OE1   . GLN A 1 538 ? 12.02678  -7.58820  57.54093  1.000 112.48603 ? 532 GLN A OE1   1 ? 
ATOM   4088 N NE2   . GLN A 1 538 ? 10.53891  -6.40654  58.73767  1.000 115.63196 ? 532 GLN A NE2   1 ? 
ATOM   4089 N N     . SER A 1 539 ? 11.71808  -12.44204 56.36636  1.000 122.52773 ? 533 SER A N     1 ? 
ATOM   4090 C CA    . SER A 1 539 ? 12.24165  -13.79774 56.49707  1.000 128.72642 ? 533 SER A CA    1 ? 
ATOM   4091 C C     . SER A 1 539 ? 13.73558  -13.77363 56.80607  1.000 134.72411 ? 533 SER A C     1 ? 
ATOM   4092 O O     . SER A 1 539 ? 14.55729  -13.50647 55.92840  1.000 132.66831 ? 533 SER A O     1 ? 
ATOM   4093 C CB    . SER A 1 539 ? 11.98232  -14.60428 55.22329  1.000 121.59556 ? 533 SER A CB    1 ? 
ATOM   4094 O OG    . SER A 1 539 ? 12.93753  -15.64129 55.07518  1.000 128.65205 ? 533 SER A OG    1 ? 
HETATM 4095 P PA    . FAD B 2 .   ? 4.61920   -1.90987  24.47731  1.000 81.81474  ? 601 FAD A PA    1 ? 
HETATM 4096 O O1A   . FAD B 2 .   ? 5.62038   -1.21612  23.58805  1.000 67.72311  ? 601 FAD A O1A   1 ? 
HETATM 4097 O O2A   . FAD B 2 .   ? 3.30904   -2.38924  23.90211  1.000 83.03013  ? 601 FAD A O2A   1 ? 
HETATM 4098 O O5B   . FAD B 2 .   ? 5.32328   -3.17308  25.18629  1.000 73.44180  ? 601 FAD A O5B   1 ? 
HETATM 4099 C C5B   . FAD B 2 .   ? 4.70753   -4.45808  25.10622  1.000 80.71109  ? 601 FAD A C5B   1 ? 
HETATM 4100 C C4B   . FAD B 2 .   ? 5.71843   -5.53611  24.73986  1.000 72.55235  ? 601 FAD A C4B   1 ? 
HETATM 4101 O O4B   . FAD B 2 .   ? 5.58917   -6.66391  25.61285  1.000 72.00627  ? 601 FAD A O4B   1 ? 
HETATM 4102 C C3B   . FAD B 2 .   ? 5.47597   -6.03848  23.32419  1.000 71.72952  ? 601 FAD A C3B   1 ? 
HETATM 4103 O O3B   . FAD B 2 .   ? 6.67683   -5.92925  22.55850  1.000 70.86058  ? 601 FAD A O3B   1 ? 
HETATM 4104 C C2B   . FAD B 2 .   ? 5.11124   -7.49973  23.46852  1.000 73.45132  ? 601 FAD A C2B   1 ? 
HETATM 4105 O O2B   . FAD B 2 .   ? 5.75365   -8.28214  22.45968  1.000 75.70718  ? 601 FAD A O2B   1 ? 
HETATM 4106 C C1B   . FAD B 2 .   ? 5.63396   -7.86902  24.84326  1.000 74.24692  ? 601 FAD A C1B   1 ? 
HETATM 4107 N N9A   . FAD B 2 .   ? 4.80279   -8.94265  25.44080  1.000 77.38614  ? 601 FAD A N9A   1 ? 
HETATM 4108 C C8A   . FAD B 2 .   ? 3.52884   -8.82693  25.85643  1.000 75.42637  ? 601 FAD A C8A   1 ? 
HETATM 4109 N N7A   . FAD B 2 .   ? 3.06736   -10.00473 26.35248  1.000 78.40811  ? 601 FAD A N7A   1 ? 
HETATM 4110 C C5A   . FAD B 2 .   ? 4.06199   -10.90575 26.24574  1.000 81.39821  ? 601 FAD A C5A   1 ? 
HETATM 4111 C C6A   . FAD B 2 .   ? 4.25026   -12.33879 26.57498  1.000 81.68304  ? 601 FAD A C6A   1 ? 
HETATM 4112 N N6A   . FAD B 2 .   ? 3.25454   -13.06785 27.13317  1.000 83.58865  ? 601 FAD A N6A   1 ? 
HETATM 4113 N N1A   . FAD B 2 .   ? 5.45004   -12.89531 26.29931  1.000 83.81446  ? 601 FAD A N1A   1 ? 
HETATM 4114 C C2A   . FAD B 2 .   ? 6.44757   -12.18585 25.74183  1.000 82.59411  ? 601 FAD A C2A   1 ? 
HETATM 4115 N N3A   . FAD B 2 .   ? 6.34941   -10.88410 25.42030  1.000 77.22613  ? 601 FAD A N3A   1 ? 
HETATM 4116 C C4A   . FAD B 2 .   ? 5.20159   -10.20029 25.64077  1.000 79.55422  ? 601 FAD A C4A   1 ? 
HETATM 4117 N N1    . FAD B 2 .   ? 1.39597   6.87954   23.89233  1.000 103.12583 ? 601 FAD A N1    1 ? 
HETATM 4118 C C2    . FAD B 2 .   ? 1.61547   8.15510   24.31068  1.000 90.06317  ? 601 FAD A C2    1 ? 
HETATM 4119 O O2    . FAD B 2 .   ? 1.56677   8.41141   25.53193  1.000 99.32428  ? 601 FAD A O2    1 ? 
HETATM 4120 N N3    . FAD B 2 .   ? 1.88555   9.16409   23.46712  1.000 85.43034  ? 601 FAD A N3    1 ? 
HETATM 4121 C C4    . FAD B 2 .   ? 1.95448   8.98213   22.14599  1.000 86.80315  ? 601 FAD A C4    1 ? 
HETATM 4122 O O4    . FAD B 2 .   ? 2.21124   9.93782   21.38709  1.000 82.74136  ? 601 FAD A O4    1 ? 
HETATM 4123 C C4X   . FAD B 2 .   ? 1.72819   7.62178   21.60303  1.000 97.06574  ? 601 FAD A C4X   1 ? 
HETATM 4124 N N5    . FAD B 2 .   ? 1.78430   7.36847   20.27880  1.000 86.11944  ? 601 FAD A N5    1 ? 
HETATM 4125 C C5X   . FAD B 2 .   ? 1.57551   6.12032   19.80372  1.000 90.67287  ? 601 FAD A C5X   1 ? 
HETATM 4126 C C6    . FAD B 2 .   ? 1.63816   5.89992   18.43259  1.000 90.34787  ? 601 FAD A C6    1 ? 
HETATM 4127 C C7    . FAD B 2 .   ? 1.42875   4.62859   17.91441  1.000 91.71232  ? 601 FAD A C7    1 ? 
HETATM 4128 C C7M   . FAD B 2 .   ? 1.50324   4.39503   16.42878  1.000 81.82278  ? 601 FAD A C7M   1 ? 
HETATM 4129 C C8    . FAD B 2 .   ? 1.12961   3.49936   18.83061  1.000 90.60972  ? 601 FAD A C8    1 ? 
HETATM 4130 C C8M   . FAD B 2 .   ? 0.89915   2.11895   18.27551  1.000 82.93489  ? 601 FAD A C8M   1 ? 
HETATM 4131 C C9    . FAD B 2 .   ? 1.05903   3.71978   20.19993  1.000 93.15736  ? 601 FAD A C9    1 ? 
HETATM 4132 C C9A   . FAD B 2 .   ? 1.27406   4.99028   20.73051  1.000 90.88995  ? 601 FAD A C9A   1 ? 
HETATM 4133 N N10   . FAD B 2 .   ? 1.21497   5.23350   22.12571  1.000 89.58670  ? 601 FAD A N10   1 ? 
HETATM 4134 C C10   . FAD B 2 .   ? 1.43476   6.55052   22.58170  1.000 92.73639  ? 601 FAD A C10   1 ? 
HETATM 4135 C "C1'" . FAD B 2 .   ? 0.92184   4.16177   23.08725  1.000 81.83105  ? 601 FAD A "C1'" 1 ? 
HETATM 4136 C "C2'" . FAD B 2 .   ? 2.12229   3.22528   23.25257  1.000 77.72222  ? 601 FAD A "C2'" 1 ? 
HETATM 4137 O "O2'" . FAD B 2 .   ? 1.65040   1.89835   23.51186  1.000 89.92894  ? 601 FAD A "O2'" 1 ? 
HETATM 4138 C "C3'" . FAD B 2 .   ? 3.07958   3.68326   24.34854  1.000 79.69875  ? 601 FAD A "C3'" 1 ? 
HETATM 4139 O "O3'" . FAD B 2 .   ? 4.26922   4.20655   23.74776  1.000 71.20290  ? 601 FAD A "O3'" 1 ? 
HETATM 4140 C "C4'" . FAD B 2 .   ? 3.45802   2.53498   25.27803  1.000 82.36277  ? 601 FAD A "C4'" 1 ? 
HETATM 4141 O "O4'" . FAD B 2 .   ? 3.90045   3.05859   26.53443  1.000 107.32030 ? 601 FAD A "O4'" 1 ? 
HETATM 4142 C "C5'" . FAD B 2 .   ? 4.55388   1.64730   24.69878  1.000 75.13105  ? 601 FAD A "C5'" 1 ? 
HETATM 4143 O "O5'" . FAD B 2 .   ? 5.46428   1.33277   25.75030  1.000 75.84127  ? 601 FAD A "O5'" 1 ? 
HETATM 4144 P P     . FAD B 2 .   ? 5.42094   -0.09730  26.48958  1.000 89.80133  ? 601 FAD A P     1 ? 
HETATM 4145 O O1P   . FAD B 2 .   ? 6.73931   -0.79406  26.27674  1.000 56.07636  ? 601 FAD A O1P   1 ? 
HETATM 4146 O O2P   . FAD B 2 .   ? 4.91833   0.10035   27.89884  1.000 61.71172  ? 601 FAD A O2P   1 ? 
HETATM 4147 O O3P   . FAD B 2 .   ? 4.28316   -0.90582  25.68911  1.000 86.73064  ? 601 FAD A O3P   1 ? 
HETATM 4148 P PA    . NAD C 3 .   ? -9.50454  2.56402   18.02586  1.000 137.61407 ? 602 NAD A PA    1 ? 
HETATM 4149 O O1A   . NAD C 3 .   ? -9.04176  1.43959   18.92251  1.000 119.07503 ? 602 NAD A O1A   1 ? 
HETATM 4150 O O2A   . NAD C 3 .   ? -9.55888  3.98457   18.53571  1.000 117.43708 ? 602 NAD A O2A   1 ? 
HETATM 4151 O O5B   . NAD C 3 .   ? -10.94790 2.18838   17.43913  1.000 119.19409 ? 602 NAD A O5B   1 ? 
HETATM 4152 C C5B   . NAD C 3 .   ? -11.01566 1.25017   16.37252  1.000 109.06432 ? 602 NAD A C5B   1 ? 
HETATM 4153 C C4B   . NAD C 3 .   ? -11.72799 1.93300   15.21695  1.000 101.55873 ? 602 NAD A C4B   1 ? 
HETATM 4154 O O4B   . NAD C 3 .   ? -12.20598 0.94778   14.30315  1.000 100.99581 ? 602 NAD A O4B   1 ? 
HETATM 4155 C C3B   . NAD C 3 .   ? -12.92228 2.72506   15.72137  1.000 101.71703 ? 602 NAD A C3B   1 ? 
HETATM 4156 O O3B   . NAD C 3 .   ? -12.84629 4.07436   15.25425  1.000 98.07373  ? 602 NAD A O3B   1 ? 
HETATM 4157 C C2B   . NAD C 3 .   ? -14.14055 2.04157   15.13953  1.000 99.68849  ? 602 NAD A C2B   1 ? 
HETATM 4158 O O2B   . NAD C 3 .   ? -15.02832 3.01239   14.57909  1.000 100.61802 ? 602 NAD A O2B   1 ? 
HETATM 4159 C C1B   . NAD C 3 .   ? -13.60072 1.12255   14.05743  1.000 98.50912  ? 602 NAD A C1B   1 ? 
HETATM 4160 N N9A   . NAD C 3 .   ? -14.26927 -0.19729  14.12588  1.000 106.85894 ? 602 NAD A N9A   1 ? 
HETATM 4161 C C8A   . NAD C 3 .   ? -14.12855 -1.09546  15.11833  1.000 104.83219 ? 602 NAD A C8A   1 ? 
HETATM 4162 N N7A   . NAD C 3 .   ? -14.87578 -2.20351  14.88270  1.000 98.44259  ? 602 NAD A N7A   1 ? 
HETATM 4163 C C5A   . NAD C 3 .   ? -15.51367 -2.01738  13.71264  1.000 97.51009  ? 602 NAD A C5A   1 ? 
HETATM 4164 C C6A   . NAD C 3 .   ? -16.45973 -2.79355  12.87836  1.000 102.23552 ? 602 NAD A C6A   1 ? 
HETATM 4165 N N6A   . NAD C 3 .   ? -16.88209 -4.02237  13.26127  1.000 103.27930 ? 602 NAD A N6A   1 ? 
HETATM 4166 N N1A   . NAD C 3 .   ? -16.88598 -2.23426  11.72412  1.000 96.68594  ? 602 NAD A N1A   1 ? 
HETATM 4167 C C2A   . NAD C 3 .   ? -16.47211 -1.01472  11.33304  1.000 91.77637  ? 602 NAD A C2A   1 ? 
HETATM 4168 N N3A   . NAD C 3 .   ? -15.61670 -0.25475  12.03975  1.000 96.35460  ? 602 NAD A N3A   1 ? 
HETATM 4169 C C4A   . NAD C 3 .   ? -15.11205 -0.69227  13.21807  1.000 100.55452 ? 602 NAD A C4A   1 ? 
HETATM 4170 O O3    . NAD C 3 .   ? -8.65603  2.56239   16.65794  1.000 121.01961 ? 602 NAD A O3    1 ? 
HETATM 4171 P PN    . NAD C 3 .   ? -7.05197  2.62735   16.67960  1.000 112.43257 ? 602 NAD A PN    1 ? 
HETATM 4172 O O1N   . NAD C 3 .   ? -6.66022  3.90691   15.98116  1.000 104.17394 ? 602 NAD A O1N   1 ? 
HETATM 4173 O O2N   . NAD C 3 .   ? -6.49258  1.30034   16.22395  1.000 106.07437 ? 602 NAD A O2N   1 ? 
HETATM 4174 O O5D   . NAD C 3 .   ? -6.75691  2.80980   18.24929  1.000 114.66087 ? 602 NAD A O5D   1 ? 
HETATM 4175 C C5D   . NAD C 3 .   ? -5.68963  2.11126   18.88338  1.000 112.90194 ? 602 NAD A C5D   1 ? 
HETATM 4176 C C4D   . NAD C 3 .   ? -5.32666  2.83714   20.16995  1.000 120.11322 ? 602 NAD A C4D   1 ? 
HETATM 4177 O O4D   . NAD C 3 .   ? -3.94224  3.18120   20.11072  1.000 130.04782 ? 602 NAD A O4D   1 ? 
HETATM 4178 C C3D   . NAD C 3 .   ? -6.12281  4.12652   20.29319  1.000 126.71252 ? 602 NAD A C3D   1 ? 
HETATM 4179 O O3D   . NAD C 3 .   ? -6.86578  4.13407   21.51562  1.000 126.15632 ? 602 NAD A O3D   1 ? 
HETATM 4180 C C2D   . NAD C 3 .   ? -5.10942  5.25195   20.29354  1.000 128.41327 ? 602 NAD A C2D   1 ? 
HETATM 4181 O O2D   . NAD C 3 .   ? -5.23384  6.02915   21.48806  1.000 123.64797 ? 602 NAD A O2D   1 ? 
HETATM 4182 C C1D   . NAD C 3 .   ? -3.74277  4.58989   20.23906  1.000 122.40078 ? 602 NAD A C1D   1 ? 
HETATM 4183 N N1N   . NAD C 3 .   ? -3.00707  5.07066   19.06958  1.000 111.10968 ? 602 NAD A N1N   1 ? 
HETATM 4184 C C2N   . NAD C 3 .   ? -2.44424  6.28259   19.09777  1.000 102.40639 ? 602 NAD A C2N   1 ? 
HETATM 4185 C C3N   . NAD C 3 .   ? -1.75075  6.76173   17.99434  1.000 106.76618 ? 602 NAD A C3N   1 ? 
HETATM 4186 C C7N   . NAD C 3 .   ? -1.11756  8.11687   18.05181  1.000 103.00925 ? 602 NAD A C7N   1 ? 
HETATM 4187 O O7N   . NAD C 3 .   ? -1.35835  8.93708   17.18149  1.000 96.28940  ? 602 NAD A O7N   1 ? 
HETATM 4188 N N7N   . NAD C 3 .   ? -0.32136  8.38969   19.08063  1.000 99.48961  ? 602 NAD A N7N   1 ? 
HETATM 4189 C C4N   . NAD C 3 .   ? -1.63068  5.97446   16.85811  1.000 99.18882  ? 602 NAD A C4N   1 ? 
HETATM 4190 C C5N   . NAD C 3 .   ? -2.22956  4.72281   16.85217  1.000 98.47932  ? 602 NAD A C5N   1 ? 
HETATM 4191 C C6N   . NAD C 3 .   ? -2.91867  4.29444   17.98070  1.000 106.28034 ? 602 NAD A C6N   1 ? 
HETATM 4192 O O     . HOH D 4 .   ? -20.01171 10.88081  23.51571  1.000 102.21104 ? 701 HOH A O     1 ? 
HETATM 4193 O O     . HOH D 4 .   ? 1.89050   20.42536  15.78460  1.000 94.57378  ? 702 HOH A O     1 ? 
HETATM 4194 O O     . HOH D 4 .   ? -23.672   -10.370   -3.863    1.000 98.48061  ? 703 HOH A O     1 ? 
HETATM 4195 O O     . HOH D 4 .   ? 19.16659  -14.28477 25.69430  1.000 79.76215  ? 704 HOH A O     1 ? 
HETATM 4196 O O     . HOH D 4 .   ? 27.42110  -3.98298  30.05889  1.000 100.54708 ? 705 HOH A O     1 ? 
HETATM 4197 O O     . HOH D 4 .   ? 1.21354   -5.32391  -2.70161  1.000 80.96902  ? 706 HOH A O     1 ? 
HETATM 4198 O O     . HOH D 4 .   ? -18.16562 6.80009   41.06066  1.000 107.32529 ? 707 HOH A O     1 ? 
HETATM 4199 O O     . HOH D 4 .   ? 12.83110  -11.11459 54.65063  1.000 111.97295 ? 708 HOH A O     1 ? 
HETATM 4200 O O     . HOH D 4 .   ? 10.83201  -8.77045  37.02111  1.000 114.49362 ? 709 HOH A O     1 ? 
HETATM 4201 O O     . HOH D 4 .   ? -11.54925 26.88025  33.21769  1.000 86.91089  ? 710 HOH A O     1 ? 
HETATM 4202 O O     . HOH D 4 .   ? 1.33260   -23.41503 32.01331  1.000 89.06748  ? 711 HOH A O     1 ? 
HETATM 4203 O O     . HOH D 4 .   ? 15.48915  -1.48502  42.18142  1.000 121.50556 ? 712 HOH A O     1 ? 
HETATM 4204 O O     . HOH D 4 .   ? 14.44531  -14.36527 13.58119  1.000 73.56370  ? 713 HOH A O     1 ? 
HETATM 4205 O O     . HOH D 4 .   ? -13.07326 32.86541  29.10660  1.000 102.15081 ? 714 HOH A O     1 ? 
HETATM 4206 O O     . HOH D 4 .   ? -16.79522 24.82096  1.86233   1.000 85.33672  ? 715 HOH A O     1 ? 
HETATM 4207 O O     . HOH D 4 .   ? -14.92589 5.54628   15.43319  1.000 73.41386  ? 716 HOH A O     1 ? 
HETATM 4208 O O     . HOH D 4 .   ? -7.84973  17.35223  8.35155   1.000 61.84504  ? 717 HOH A O     1 ? 
HETATM 4209 O O     . HOH D 4 .   ? 18.82945  5.46338   35.28972  1.000 70.32600  ? 718 HOH A O     1 ? 
HETATM 4210 O O     . HOH D 4 .   ? -11.92866 0.83362   -2.94998  1.000 59.15074  ? 719 HOH A O     1 ? 
HETATM 4211 O O     . HOH D 4 .   ? 8.22383   -11.04241 27.84677  1.000 104.93948 ? 720 HOH A O     1 ? 
HETATM 4212 O O     . HOH D 4 .   ? -4.02126  2.61195   32.84163  1.000 77.66124  ? 721 HOH A O     1 ? 
HETATM 4213 O O     . HOH D 4 .   ? -4.73825  22.20341  19.02524  1.000 93.31027  ? 722 HOH A O     1 ? 
HETATM 4214 O O     . HOH D 4 .   ? 13.82748  28.48111  15.14274  1.000 84.76381  ? 723 HOH A O     1 ? 
HETATM 4215 O O     . HOH D 4 .   ? 14.29380  -24.87365 37.72501  1.000 95.65542  ? 724 HOH A O     1 ? 
HETATM 4216 O O     . HOH D 4 .   ? -14.91240 -8.34830  17.71787  1.000 111.47221 ? 725 HOH A O     1 ? 
HETATM 4217 O O     . HOH D 4 .   ? 15.98548  15.76337  21.86831  1.000 96.87560  ? 726 HOH A O     1 ? 
HETATM 4218 O O     . HOH D 4 .   ? 0.68502   22.54623  39.06476  1.000 81.79467  ? 727 HOH A O     1 ? 
HETATM 4219 O O     . HOH D 4 .   ? -18.19050 -6.29601  12.65764  1.000 114.14963 ? 728 HOH A O     1 ? 
HETATM 4220 O O     . HOH D 4 .   ? 0.58316   -11.02094 26.62883  1.000 73.55383  ? 729 HOH A O     1 ? 
HETATM 4221 O O     . HOH D 4 .   ? 8.784     24.080    10.106    1.000 68.40925  ? 730 HOH A O     1 ? 
HETATM 4222 O O     . HOH D 4 .   ? 3.69028   3.24042   57.65052  1.000 88.65164  ? 731 HOH A O     1 ? 
HETATM 4223 O O     . HOH D 4 .   ? -3.98975  19.93020  3.40922   1.000 73.37587  ? 732 HOH A O     1 ? 
HETATM 4224 O O     . HOH D 4 .   ? -17.39144 -9.14470  -6.76030  1.000 91.97700  ? 733 HOH A O     1 ? 
HETATM 4225 O O     . HOH D 4 .   ? -15.91578 9.27544   45.79282  1.000 88.43184  ? 734 HOH A O     1 ? 
HETATM 4226 O O     . HOH D 4 .   ? -20.91874 -6.31815  -8.17178  1.000 94.49205  ? 735 HOH A O     1 ? 
HETATM 4227 O O     . HOH D 4 .   ? -1.72218  11.87085  13.41810  1.000 55.42130  ? 736 HOH A O     1 ? 
HETATM 4228 O O     . HOH D 4 .   ? -1.21369  -12.11610 20.10139  1.000 111.74513 ? 737 HOH A O     1 ? 
HETATM 4229 O O     . HOH D 4 .   ? 21.07235  1.17929   49.26130  1.000 79.90789  ? 738 HOH A O     1 ? 
HETATM 4230 O O     . HOH D 4 .   ? -3.72869  -7.08167  -4.99931  1.000 70.13672  ? 739 HOH A O     1 ? 
HETATM 4231 O O     . HOH D 4 .   ? -20.72322 5.24092   29.86496  1.000 78.88687  ? 740 HOH A O     1 ? 
HETATM 4232 O O     . HOH D 4 .   ? 28.01643  4.24531   21.23799  1.000 80.88212  ? 741 HOH A O     1 ? 
HETATM 4233 O O     . HOH D 4 .   ? -1.10864  18.59591  10.00395  1.000 75.25855  ? 742 HOH A O     1 ? 
HETATM 4234 O O     . HOH D 4 .   ? -22.32002 11.69723  23.76465  1.000 91.18227  ? 743 HOH A O     1 ? 
HETATM 4235 O O     . HOH D 4 .   ? 20.68565  -17.96118 39.26476  1.000 98.79229  ? 744 HOH A O     1 ? 
HETATM 4236 O O     . HOH D 4 .   ? 8.19781   9.81890   48.13664  1.000 106.58927 ? 745 HOH A O     1 ? 
HETATM 4237 O O     . HOH D 4 .   ? 17.20018  24.08702  30.86635  1.000 83.01642  ? 746 HOH A O     1 ? 
HETATM 4238 O O     . HOH D 4 .   ? -18.10098 27.58257  30.55235  1.000 81.39686  ? 747 HOH A O     1 ? 
HETATM 4239 O O     . HOH D 4 .   ? -19.28051 36.60028  26.75983  1.000 80.51687  ? 748 HOH A O     1 ? 
HETATM 4240 O O     . HOH D 4 .   ? -20.07185 2.60102   17.47259  1.000 101.09155 ? 749 HOH A O     1 ? 
HETATM 4241 O O     . HOH D 4 .   ? 23.26453  29.92104  22.07688  1.000 77.38033  ? 750 HOH A O     1 ? 
HETATM 4242 O O     . HOH D 4 .   ? -22.89382 18.71334  25.13228  1.000 99.91874  ? 751 HOH A O     1 ? 
HETATM 4243 O O     . HOH D 4 .   ? -5.68864  -9.93508  33.56499  1.000 119.67261 ? 752 HOH A O     1 ? 
HETATM 4244 O O     . HOH D 4 .   ? 12.45580  -19.02590 19.82848  1.000 93.80601  ? 753 HOH A O     1 ? 
HETATM 4245 O O     . HOH D 4 .   ? 25.11030  -4.65109  37.78771  1.000 85.06153  ? 754 HOH A O     1 ? 
HETATM 4246 O O     . HOH D 4 .   ? 6.69636   15.96582  40.53620  1.000 67.28074  ? 755 HOH A O     1 ? 
HETATM 4247 O O     . HOH D 4 .   ? 18.35848  -7.34758  17.25559  1.000 79.44103  ? 756 HOH A O     1 ? 
HETATM 4248 O O     . HOH D 4 .   ? -6.35200  -9.01170  39.08545  1.000 106.74437 ? 757 HOH A O     1 ? 
HETATM 4249 O O     . HOH D 4 .   ? -1.14108  7.76532   26.58705  1.000 78.52394  ? 758 HOH A O     1 ? 
HETATM 4250 O O     . HOH D 4 .   ? 14.01686  -8.12396  47.51241  1.000 97.83843  ? 759 HOH A O     1 ? 
HETATM 4251 O O     . HOH D 4 .   ? 2.74216   -14.23615 23.75866  1.000 70.58214  ? 760 HOH A O     1 ? 
HETATM 4252 O O     . HOH D 4 .   ? -4.60463  18.26193  9.26249   1.000 68.35438  ? 761 HOH A O     1 ? 
HETATM 4253 O O     . HOH D 4 .   ? 13.50554  4.22745   37.01345  1.000 95.14921  ? 762 HOH A O     1 ? 
HETATM 4254 O O     . HOH D 4 .   ? 3.28913   -7.71092  0.85317   1.000 81.97882  ? 763 HOH A O     1 ? 
HETATM 4255 O O     . HOH D 4 .   ? -11.44656 -7.40264  42.70533  1.000 91.17470  ? 764 HOH A O     1 ? 
HETATM 4256 O O     . HOH D 4 .   ? 8.67050   -6.22924  56.08423  1.000 120.00048 ? 765 HOH A O     1 ? 
HETATM 4257 O O     . HOH D 4 .   ? -13.55669 39.01282  25.58916  1.000 96.48318  ? 766 HOH A O     1 ? 
HETATM 4258 O O     . HOH D 4 .   ? 7.99071   11.08161  42.79936  1.000 71.31535  ? 767 HOH A O     1 ? 
HETATM 4259 O O     . HOH D 4 .   ? 16.96304  33.05505  21.95020  1.000 92.98437  ? 768 HOH A O     1 ? 
HETATM 4260 O O     . HOH D 4 .   ? -14.92669 0.20698   19.03362  1.000 76.83698  ? 769 HOH A O     1 ? 
HETATM 4261 O O     . HOH D 4 .   ? -15.95689 11.12580  -0.71525  1.000 63.71644  ? 770 HOH A O     1 ? 
HETATM 4262 O O     . HOH D 4 .   ? 22.97913  28.52491  25.19355  1.000 81.93116  ? 771 HOH A O     1 ? 
HETATM 4263 O O     . HOH D 4 .   ? -18.38921 9.67372   -0.77035  1.000 62.60506  ? 772 HOH A O     1 ? 
HETATM 4264 O O     . HOH D 4 .   ? -20.40999 34.45316  26.27524  1.000 90.01214  ? 773 HOH A O     1 ? 
HETATM 4265 O O     . HOH D 4 .   ? 23.97570  -7.30546  37.65095  1.000 91.92094  ? 774 HOH A O     1 ? 
HETATM 4266 O O     . HOH D 4 .   ? -9.44456  29.24689  8.42815   1.000 78.42589  ? 775 HOH A O     1 ? 
HETATM 4267 O O     . HOH D 4 .   ? -18.49573 16.39667  26.85315  1.000 102.79113 ? 776 HOH A O     1 ? 
HETATM 4268 O O     . HOH D 4 .   ? -24.08477 18.46773  -2.41128  1.000 92.24235  ? 777 HOH A O     1 ? 
HETATM 4269 O O     . HOH D 4 .   ? -9.21856  29.00775  36.85968  1.000 83.26306  ? 778 HOH A O     1 ? 
HETATM 4270 O O     . HOH D 4 .   ? 11.67425  -1.36351  38.70756  1.000 98.47303  ? 779 HOH A O     1 ? 
HETATM 4271 O O     . HOH D 4 .   ? -7.40094  22.32392  3.37172   1.000 78.27711  ? 780 HOH A O     1 ? 
HETATM 4272 O O     . HOH D 4 .   ? -28.60812 1.65407   3.05841   1.000 87.85866  ? 781 HOH A O     1 ? 
HETATM 4273 O O     . HOH D 4 .   ? -3.46549  14.20965  50.38702  1.000 79.19230  ? 782 HOH A O     1 ? 
HETATM 4274 O O     . HOH D 4 .   ? 2.85672   -23.52270 33.95213  1.000 109.04983 ? 783 HOH A O     1 ? 
HETATM 4275 O O     . HOH D 4 .   ? -11.57287 -10.46527 5.78945   1.000 111.40006 ? 784 HOH A O     1 ? 
HETATM 4276 O O     . HOH D 4 .   ? 6.64944   -1.07647  6.82750   1.000 72.30363  ? 785 HOH A O     1 ? 
HETATM 4277 O O     . HOH D 4 .   ? -20.74811 22.12539  1.88175   1.000 96.14600  ? 786 HOH A O     1 ? 
HETATM 4278 O O     . HOH D 4 .   ? -4.12715  12.73888  48.72886  1.000 91.65075  ? 787 HOH A O     1 ? 
HETATM 4279 O O     . HOH D 4 .   ? 16.07407  -2.73630  58.37368  1.000 99.71361  ? 788 HOH A O     1 ? 
HETATM 4280 O O     . HOH D 4 .   ? -14.82476 14.13429  -6.22805  1.000 70.21839  ? 789 HOH A O     1 ? 
HETATM 4281 O O     . HOH D 4 .   ? -6.67185  -9.13911  24.20047  1.000 85.81446  ? 790 HOH A O     1 ? 
HETATM 4282 O O     . HOH D 4 .   ? 11.03941  -15.93253 14.99142  1.000 77.75332  ? 791 HOH A O     1 ? 
HETATM 4283 O O     . HOH D 4 .   ? -0.59727  28.90871  23.93090  1.000 79.05641  ? 792 HOH A O     1 ? 
HETATM 4284 O O     . HOH D 4 .   ? -20.56581 -11.20459 37.67316  1.000 84.80038  ? 793 HOH A O     1 ? 
HETATM 4285 O O     . HOH D 4 .   ? 11.20936  -25.11510 22.43319  1.000 104.82339 ? 794 HOH A O     1 ? 
HETATM 4286 O O     . HOH D 4 .   ? 0.65164   13.59981  5.65171   1.000 75.86673  ? 795 HOH A O     1 ? 
HETATM 4287 O O     . HOH D 4 .   ? -12.17586 5.47008   49.35851  1.000 94.50383  ? 796 HOH A O     1 ? 
HETATM 4288 O O     . HOH D 4 .   ? 28.67746  6.18031   22.72876  1.000 74.02761  ? 797 HOH A O     1 ? 
HETATM 4289 O O     . HOH D 4 .   ? -20.87897 -5.50366  10.91033  1.000 82.08473  ? 798 HOH A O     1 ? 
HETATM 4290 O O     . HOH D 4 .   ? 12.37813  -5.34042  5.43089   1.000 91.80536  ? 799 HOH A O     1 ? 
HETATM 4291 O O     . HOH D 4 .   ? -17.85594 38.87072  14.76677  1.000 94.66748  ? 800 HOH A O     1 ? 
HETATM 4292 O O     . HOH D 4 .   ? -5.86164  15.25062  -0.35471  1.000 74.12615  ? 801 HOH A O     1 ? 
HETATM 4293 O O     . HOH D 4 .   ? 16.88192  9.03840   9.57533   1.000 76.07781  ? 802 HOH A O     1 ? 
HETATM 4294 O O     . HOH D 4 .   ? 20.84687  7.40156   12.66498  1.000 91.48059  ? 803 HOH A O     1 ? 
HETATM 4295 O O     . HOH D 4 .   ? -18.85131 23.80888  1.35226   1.000 84.61313  ? 804 HOH A O     1 ? 
HETATM 4296 O O     . HOH D 4 .   ? -7.01141  15.83851  24.65688  1.000 113.34867 ? 805 HOH A O     1 ? 
HETATM 4297 O O     . HOH D 4 .   ? -15.31047 -13.33714 11.94906  1.000 86.04603  ? 806 HOH A O     1 ? 
HETATM 4298 O O     . HOH D 4 .   ? -11.22567 33.84519  24.63205  1.000 118.99885 ? 807 HOH A O     1 ? 
HETATM 4299 O O     . HOH D 4 .   ? -20.10624 -3.31518  9.91825   1.000 76.27384  ? 808 HOH A O     1 ? 
HETATM 4300 O O     . HOH D 4 .   ? 20.93107  6.06776   34.58235  1.000 60.81990  ? 809 HOH A O     1 ? 
HETATM 4301 O O     . HOH D 4 .   ? 19.51571  1.68263   29.29345  1.000 103.61308 ? 810 HOH A O     1 ? 
HETATM 4302 O O     . HOH D 4 .   ? 17.56091  -10.97619 49.89784  1.000 98.75503  ? 811 HOH A O     1 ? 
HETATM 4303 O O     . HOH D 4 .   ? -19.75882 7.58804   -2.06179  1.000 89.68956  ? 812 HOH A O     1 ? 
HETATM 4304 O O     . HOH D 4 .   ? 15.14850  -14.52346 59.49918  1.000 90.12170  ? 813 HOH A O     1 ? 
HETATM 4305 O O     . HOH D 4 .   ? -11.38670 -4.49780  9.36460   1.000 94.08331  ? 814 HOH A O     1 ? 
HETATM 4306 O O     . HOH D 4 .   ? -12.08363 3.47030   21.32881  1.000 71.81821  ? 815 HOH A O     1 ? 
HETATM 4307 O O     . HOH D 4 .   ? -14.20370 18.01749  21.78617  1.000 86.71761  ? 816 HOH A O     1 ? 
HETATM 4308 O O     . HOH D 4 .   ? -12.44488 7.49611   24.00282  1.000 108.50169 ? 817 HOH A O     1 ? 
HETATM 4309 O O     . HOH D 4 .   ? -13.80983 5.86182   35.14215  1.000 103.92733 ? 818 HOH A O     1 ? 
HETATM 4310 O O     . HOH D 4 .   ? -26.23822 4.30424   3.71422   1.000 89.93364  ? 819 HOH A O     1 ? 
HETATM 4311 O O     . HOH D 4 .   ? 20.70712  1.54023   46.89893  1.000 82.15244  ? 820 HOH A O     1 ? 
HETATM 4312 O O     . HOH D 4 .   ? -3.89342  2.27922   28.99629  1.000 95.67939  ? 821 HOH A O     1 ? 
HETATM 4313 O O     . HOH D 4 .   ? -23.31017 -15.74739 -4.32415  1.000 74.16898  ? 822 HOH A O     1 ? 
# 
