data_8YTL
# 
_entry.id   8YTL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YTL         pdb_00008ytl 10.2210/pdb8ytl/pdb 
WWPDB D_1300046362 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YTL 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          8YT6 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yo@phs.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Takuya 
_pdbx_contact_author.name_last          Yoshida 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3491-9344 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachibana, K.' 1  ? 
'Morie, T.'     2  ? 
'Fukuda, S.'    3  ? 
'Yuzuriha, T.'  4  ? 
'Ishimoto, K.'  5  ? 
'Nunomura, K.'  6  ? 
'Lin, B.'       7  ? 
'Miyachi, H.'   8  ? 
'Oki, H.'       9  ? 
'Kawahara, K.'  10 ? 
'Meguro, K.'    11 ? 
'Nakagawa, S.'  12 ? 
'Tsujikawa, K.' 13 ? 
'Akai, S.'      14 ? 
'Doi, T.'       15 ? 
'Yoshida, T.'   16 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachibana, K.' 1  ? 
primary 'Morie, T.'     2  ? 
primary 'Fukuda, S.'    3  ? 
primary 'Yuzuriha, T.'  4  ? 
primary 'Ishimoto, K.'  5  ? 
primary 'Nunomura, K.'  6  ? 
primary 'Lin, B.'       7  ? 
primary 'Miyachi, H.'   8  ? 
primary 'Oki, H.'       9  ? 
primary 'Kawahara, K.'  10 ? 
primary 'Meguro, K.'    11 ? 
primary 'Nakagawa, S.'  12 ? 
primary 'Tsujikawa, K.' 13 ? 
primary 'Akai, S.'      14 ? 
primary 'Doi, T.'       15 ? 
primary 'Yoshida, T.'   16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peroxisome proliferator-activated receptor alpha' 30684.814 1   ? ? ? ? 
2 polymer     man 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha' 2405.782  1   ? ? ? ? 
3 non-polymer syn S-1,2-PROPANEDIOL 76.094    1   ? ? ? ? 
4 non-polymer syn 
'1-(4-fluorophenyl)-6-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
511.588   1   ? ? ? ? 
5 water       nat water 18.015    113 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'PPAR-alpha,Nuclear receptor subfamily 1 group C member 1'                            
2 'PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
A ? 
2 'polypeptide(L)' no no PQEAEEPSLLKKLLLAPANTQL PQEAEEPSLLKKLLLAPANTQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 S-1,2-PROPANEDIOL PGO   
4 
'1-(4-fluorophenyl)-6-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
A1LZ0 
5 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   GLN n 
1 4   THR n 
1 5   ALA n 
1 6   ASP n 
1 7   LEU n 
1 8   LYS n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  LYS n 
1 13  ARG n 
1 14  ILE n 
1 15  TYR n 
1 16  GLU n 
1 17  ALA n 
1 18  TYR n 
1 19  LEU n 
1 20  LYS n 
1 21  ASN n 
1 22  PHE n 
1 23  ASN n 
1 24  MET n 
1 25  ASN n 
1 26  LYS n 
1 27  VAL n 
1 28  LYS n 
1 29  ALA n 
1 30  ARG n 
1 31  VAL n 
1 32  ILE n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  LYS n 
1 37  ALA n 
1 38  SER n 
1 39  ASN n 
1 40  ASN n 
1 41  PRO n 
1 42  PRO n 
1 43  PHE n 
1 44  VAL n 
1 45  ILE n 
1 46  HIS n 
1 47  ASP n 
1 48  MET n 
1 49  GLU n 
1 50  THR n 
1 51  LEU n 
1 52  CYS n 
1 53  MET n 
1 54  ALA n 
1 55  GLU n 
1 56  LYS n 
1 57  THR n 
1 58  LEU n 
1 59  VAL n 
1 60  ALA n 
1 61  LYS n 
1 62  LEU n 
1 63  VAL n 
1 64  ALA n 
1 65  ASN n 
1 66  GLY n 
1 67  ILE n 
1 68  GLN n 
1 69  ASN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLU n 
1 74  VAL n 
1 75  ARG n 
1 76  ILE n 
1 77  PHE n 
1 78  HIS n 
1 79  CYS n 
1 80  CYS n 
1 81  GLN n 
1 82  CYS n 
1 83  THR n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  THR n 
1 88  VAL n 
1 89  THR n 
1 90  GLU n 
1 91  LEU n 
1 92  THR n 
1 93  GLU n 
1 94  PHE n 
1 95  ALA n 
1 96  LYS n 
1 97  ALA n 
1 98  ILE n 
1 99  PRO n 
1 100 GLY n 
1 101 PHE n 
1 102 ALA n 
1 103 ASN n 
1 104 LEU n 
1 105 ASP n 
1 106 LEU n 
1 107 ASN n 
1 108 ASP n 
1 109 GLN n 
1 110 VAL n 
1 111 THR n 
1 112 LEU n 
1 113 LEU n 
1 114 LYS n 
1 115 TYR n 
1 116 GLY n 
1 117 VAL n 
1 118 TYR n 
1 119 GLU n 
1 120 ALA n 
1 121 ILE n 
1 122 PHE n 
1 123 ALA n 
1 124 MET n 
1 125 LEU n 
1 126 SER n 
1 127 SER n 
1 128 VAL n 
1 129 MET n 
1 130 ASN n 
1 131 LYS n 
1 132 ASP n 
1 133 GLY n 
1 134 MET n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 TYR n 
1 139 GLY n 
1 140 ASN n 
1 141 GLY n 
1 142 PHE n 
1 143 ILE n 
1 144 THR n 
1 145 ARG n 
1 146 GLU n 
1 147 PHE n 
1 148 LEU n 
1 149 LYS n 
1 150 SER n 
1 151 LEU n 
1 152 ARG n 
1 153 LYS n 
1 154 PRO n 
1 155 PHE n 
1 156 CYS n 
1 157 ASP n 
1 158 ILE n 
1 159 MET n 
1 160 GLU n 
1 161 PRO n 
1 162 LYS n 
1 163 PHE n 
1 164 ASP n 
1 165 PHE n 
1 166 ALA n 
1 167 MET n 
1 168 LYS n 
1 169 PHE n 
1 170 ASN n 
1 171 ALA n 
1 172 LEU n 
1 173 GLU n 
1 174 LEU n 
1 175 ASP n 
1 176 ASP n 
1 177 SER n 
1 178 ASP n 
1 179 ILE n 
1 180 SER n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 ALA n 
1 185 ALA n 
1 186 ILE n 
1 187 ILE n 
1 188 CYS n 
1 189 CYS n 
1 190 GLY n 
1 191 ASP n 
1 192 ARG n 
1 193 PRO n 
1 194 GLY n 
1 195 LEU n 
1 196 LEU n 
1 197 ASN n 
1 198 VAL n 
1 199 GLY n 
1 200 HIS n 
1 201 ILE n 
1 202 GLU n 
1 203 LYS n 
1 204 MET n 
1 205 GLN n 
1 206 GLU n 
1 207 GLY n 
1 208 ILE n 
1 209 VAL n 
1 210 HIS n 
1 211 VAL n 
1 212 LEU n 
1 213 ARG n 
1 214 LEU n 
1 215 HIS n 
1 216 LEU n 
1 217 GLN n 
1 218 SER n 
1 219 ASN n 
1 220 HIS n 
1 221 PRO n 
1 222 ASP n 
1 223 ASP n 
1 224 ILE n 
1 225 PHE n 
1 226 LEU n 
1 227 PHE n 
1 228 PRO n 
1 229 LYS n 
1 230 LEU n 
1 231 LEU n 
1 232 GLN n 
1 233 LYS n 
1 234 MET n 
1 235 ALA n 
1 236 ASP n 
1 237 LEU n 
1 238 ARG n 
1 239 GLN n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 GLU n 
1 244 HIS n 
1 245 ALA n 
1 246 GLN n 
1 247 LEU n 
1 248 VAL n 
1 249 GLN n 
1 250 ILE n 
1 251 ILE n 
1 252 LYS n 
1 253 LYS n 
1 254 THR n 
1 255 GLU n 
1 256 SER n 
1 257 ASP n 
1 258 ALA n 
1 259 ALA n 
1 260 LEU n 
1 261 HIS n 
1 262 PRO n 
1 263 LEU n 
1 264 LEU n 
1 265 GLN n 
1 266 GLU n 
1 267 ILE n 
1 268 TYR n 
1 269 ARG n 
1 270 ASP n 
1 271 MET n 
1 272 TYR n 
2 1   PRO n 
2 2   GLN n 
2 3   GLU n 
2 4   ALA n 
2 5   GLU n 
2 6   GLU n 
2 7   PRO n 
2 8   SER n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  LYS n 
2 13  LEU n 
2 14  LEU n 
2 15  LEU n 
2 16  ALA n 
2 17  PRO n 
2 18  ALA n 
2 19  ASN n 
2 20  THR n 
2 21  GLN n 
2 22  LEU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 272 human ? 'PPARA, NR1C1, PPAR'                   ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? 
? ? 'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 22  human ? 'PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? 
? ? 'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LZ0 non-polymer         . 
'1-(4-fluorophenyl)-6-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
? 'C27 H34 F N5 O4' 511.588 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PGO   non-polymer         . S-1,2-PROPANEDIOL ? 'C3 H8 O2'        76.094  
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   197 ?   ?   ?   A . n 
A 1 2   GLY 2   198 ?   ?   ?   A . n 
A 1 3   GLN 3   199 ?   ?   ?   A . n 
A 1 4   THR 4   200 ?   ?   ?   A . n 
A 1 5   ALA 5   201 ?   ?   ?   A . n 
A 1 6   ASP 6   202 202 ASP ASP A . n 
A 1 7   LEU 7   203 203 LEU LEU A . n 
A 1 8   LYS 8   204 204 LYS LYS A . n 
A 1 9   SER 9   205 205 SER SER A . n 
A 1 10  LEU 10  206 206 LEU LEU A . n 
A 1 11  ALA 11  207 207 ALA ALA A . n 
A 1 12  LYS 12  208 208 LYS LYS A . n 
A 1 13  ARG 13  209 209 ARG ARG A . n 
A 1 14  ILE 14  210 210 ILE ILE A . n 
A 1 15  TYR 15  211 211 TYR TYR A . n 
A 1 16  GLU 16  212 212 GLU GLU A . n 
A 1 17  ALA 17  213 213 ALA ALA A . n 
A 1 18  TYR 18  214 214 TYR TYR A . n 
A 1 19  LEU 19  215 215 LEU LEU A . n 
A 1 20  LYS 20  216 216 LYS LYS A . n 
A 1 21  ASN 21  217 217 ASN ASN A . n 
A 1 22  PHE 22  218 218 PHE PHE A . n 
A 1 23  ASN 23  219 219 ASN ASN A . n 
A 1 24  MET 24  220 220 MET MET A . n 
A 1 25  ASN 25  221 221 ASN ASN A . n 
A 1 26  LYS 26  222 222 LYS LYS A . n 
A 1 27  VAL 27  223 223 VAL VAL A . n 
A 1 28  LYS 28  224 224 LYS LYS A . n 
A 1 29  ALA 29  225 225 ALA ALA A . n 
A 1 30  ARG 30  226 226 ARG ARG A . n 
A 1 31  VAL 31  227 227 VAL VAL A . n 
A 1 32  ILE 32  228 228 ILE ILE A . n 
A 1 33  LEU 33  229 229 LEU LEU A . n 
A 1 34  SER 34  230 230 SER SER A . n 
A 1 35  GLY 35  231 ?   ?   ?   A . n 
A 1 36  LYS 36  232 ?   ?   ?   A . n 
A 1 37  ALA 37  233 ?   ?   ?   A . n 
A 1 38  SER 38  234 ?   ?   ?   A . n 
A 1 39  ASN 39  235 ?   ?   ?   A . n 
A 1 40  ASN 40  236 ?   ?   ?   A . n 
A 1 41  PRO 41  237 ?   ?   ?   A . n 
A 1 42  PRO 42  238 238 PRO PRO A . n 
A 1 43  PHE 43  239 239 PHE PHE A . n 
A 1 44  VAL 44  240 240 VAL VAL A . n 
A 1 45  ILE 45  241 241 ILE ILE A . n 
A 1 46  HIS 46  242 242 HIS HIS A . n 
A 1 47  ASP 47  243 243 ASP ASP A . n 
A 1 48  MET 48  244 244 MET MET A . n 
A 1 49  GLU 49  245 245 GLU GLU A . n 
A 1 50  THR 50  246 246 THR THR A . n 
A 1 51  LEU 51  247 247 LEU LEU A . n 
A 1 52  CYS 52  248 248 CYS CYS A . n 
A 1 53  MET 53  249 249 MET MET A . n 
A 1 54  ALA 54  250 250 ALA ALA A . n 
A 1 55  GLU 55  251 251 GLU GLU A . n 
A 1 56  LYS 56  252 252 LYS LYS A . n 
A 1 57  THR 57  253 253 THR THR A . n 
A 1 58  LEU 58  254 254 LEU LEU A . n 
A 1 59  VAL 59  255 255 VAL VAL A . n 
A 1 60  ALA 60  256 256 ALA ALA A . n 
A 1 61  LYS 61  257 257 LYS LYS A . n 
A 1 62  LEU 62  258 258 LEU LEU A . n 
A 1 63  VAL 63  259 ?   ?   ?   A . n 
A 1 64  ALA 64  260 ?   ?   ?   A . n 
A 1 65  ASN 65  261 ?   ?   ?   A . n 
A 1 66  GLY 66  262 ?   ?   ?   A . n 
A 1 67  ILE 67  263 ?   ?   ?   A . n 
A 1 68  GLN 68  264 ?   ?   ?   A . n 
A 1 69  ASN 69  265 265 ASN ASN A . n 
A 1 70  LYS 70  266 266 LYS LYS A . n 
A 1 71  GLU 71  267 267 GLU GLU A . n 
A 1 72  ALA 72  268 268 ALA ALA A . n 
A 1 73  GLU 73  269 269 GLU GLU A . n 
A 1 74  VAL 74  270 270 VAL VAL A . n 
A 1 75  ARG 75  271 271 ARG ARG A . n 
A 1 76  ILE 76  272 272 ILE ILE A . n 
A 1 77  PHE 77  273 273 PHE PHE A . n 
A 1 78  HIS 78  274 274 HIS HIS A . n 
A 1 79  CYS 79  275 275 CYS CYS A . n 
A 1 80  CYS 80  276 276 CYS CYS A . n 
A 1 81  GLN 81  277 277 GLN GLN A . n 
A 1 82  CYS 82  278 278 CYS CYS A . n 
A 1 83  THR 83  279 279 THR THR A . n 
A 1 84  SER 84  280 280 SER SER A . n 
A 1 85  VAL 85  281 281 VAL VAL A . n 
A 1 86  GLU 86  282 282 GLU GLU A . n 
A 1 87  THR 87  283 283 THR THR A . n 
A 1 88  VAL 88  284 284 VAL VAL A . n 
A 1 89  THR 89  285 285 THR THR A . n 
A 1 90  GLU 90  286 286 GLU GLU A . n 
A 1 91  LEU 91  287 287 LEU LEU A . n 
A 1 92  THR 92  288 288 THR THR A . n 
A 1 93  GLU 93  289 289 GLU GLU A . n 
A 1 94  PHE 94  290 290 PHE PHE A . n 
A 1 95  ALA 95  291 291 ALA ALA A . n 
A 1 96  LYS 96  292 292 LYS LYS A . n 
A 1 97  ALA 97  293 293 ALA ALA A . n 
A 1 98  ILE 98  294 294 ILE ILE A . n 
A 1 99  PRO 99  295 295 PRO PRO A . n 
A 1 100 GLY 100 296 296 GLY GLY A . n 
A 1 101 PHE 101 297 297 PHE PHE A . n 
A 1 102 ALA 102 298 298 ALA ALA A . n 
A 1 103 ASN 103 299 299 ASN ASN A . n 
A 1 104 LEU 104 300 300 LEU LEU A . n 
A 1 105 ASP 105 301 301 ASP ASP A . n 
A 1 106 LEU 106 302 302 LEU LEU A . n 
A 1 107 ASN 107 303 303 ASN ASN A . n 
A 1 108 ASP 108 304 304 ASP ASP A . n 
A 1 109 GLN 109 305 305 GLN GLN A . n 
A 1 110 VAL 110 306 306 VAL VAL A . n 
A 1 111 THR 111 307 307 THR THR A . n 
A 1 112 LEU 112 308 308 LEU LEU A . n 
A 1 113 LEU 113 309 309 LEU LEU A . n 
A 1 114 LYS 114 310 310 LYS LYS A . n 
A 1 115 TYR 115 311 311 TYR TYR A . n 
A 1 116 GLY 116 312 312 GLY GLY A . n 
A 1 117 VAL 117 313 313 VAL VAL A . n 
A 1 118 TYR 118 314 314 TYR TYR A . n 
A 1 119 GLU 119 315 315 GLU GLU A . n 
A 1 120 ALA 120 316 316 ALA ALA A . n 
A 1 121 ILE 121 317 317 ILE ILE A . n 
A 1 122 PHE 122 318 318 PHE PHE A . n 
A 1 123 ALA 123 319 319 ALA ALA A . n 
A 1 124 MET 124 320 320 MET MET A . n 
A 1 125 LEU 125 321 321 LEU LEU A . n 
A 1 126 SER 126 322 322 SER SER A . n 
A 1 127 SER 127 323 323 SER SER A . n 
A 1 128 VAL 128 324 324 VAL VAL A . n 
A 1 129 MET 129 325 325 MET MET A . n 
A 1 130 ASN 130 326 326 ASN ASN A . n 
A 1 131 LYS 131 327 327 LYS LYS A . n 
A 1 132 ASP 132 328 328 ASP ASP A . n 
A 1 133 GLY 133 329 329 GLY GLY A . n 
A 1 134 MET 134 330 330 MET MET A . n 
A 1 135 LEU 135 331 331 LEU LEU A . n 
A 1 136 VAL 136 332 332 VAL VAL A . n 
A 1 137 ALA 137 333 333 ALA ALA A . n 
A 1 138 TYR 138 334 334 TYR TYR A . n 
A 1 139 GLY 139 335 335 GLY GLY A . n 
A 1 140 ASN 140 336 336 ASN ASN A . n 
A 1 141 GLY 141 337 337 GLY GLY A . n 
A 1 142 PHE 142 338 338 PHE PHE A . n 
A 1 143 ILE 143 339 339 ILE ILE A . n 
A 1 144 THR 144 340 340 THR THR A . n 
A 1 145 ARG 145 341 341 ARG ARG A . n 
A 1 146 GLU 146 342 342 GLU GLU A . n 
A 1 147 PHE 147 343 343 PHE PHE A . n 
A 1 148 LEU 148 344 344 LEU LEU A . n 
A 1 149 LYS 149 345 345 LYS LYS A . n 
A 1 150 SER 150 346 346 SER SER A . n 
A 1 151 LEU 151 347 347 LEU LEU A . n 
A 1 152 ARG 152 348 348 ARG ARG A . n 
A 1 153 LYS 153 349 349 LYS LYS A . n 
A 1 154 PRO 154 350 350 PRO PRO A . n 
A 1 155 PHE 155 351 351 PHE PHE A . n 
A 1 156 CYS 156 352 352 CYS CYS A . n 
A 1 157 ASP 157 353 353 ASP ASP A . n 
A 1 158 ILE 158 354 354 ILE ILE A . n 
A 1 159 MET 159 355 355 MET MET A . n 
A 1 160 GLU 160 356 356 GLU GLU A . n 
A 1 161 PRO 161 357 357 PRO PRO A . n 
A 1 162 LYS 162 358 358 LYS LYS A . n 
A 1 163 PHE 163 359 359 PHE PHE A . n 
A 1 164 ASP 164 360 360 ASP ASP A . n 
A 1 165 PHE 165 361 361 PHE PHE A . n 
A 1 166 ALA 166 362 362 ALA ALA A . n 
A 1 167 MET 167 363 363 MET MET A . n 
A 1 168 LYS 168 364 364 LYS LYS A . n 
A 1 169 PHE 169 365 365 PHE PHE A . n 
A 1 170 ASN 170 366 366 ASN ASN A . n 
A 1 171 ALA 171 367 367 ALA ALA A . n 
A 1 172 LEU 172 368 368 LEU LEU A . n 
A 1 173 GLU 173 369 369 GLU GLU A . n 
A 1 174 LEU 174 370 370 LEU LEU A . n 
A 1 175 ASP 175 371 371 ASP ASP A . n 
A 1 176 ASP 176 372 372 ASP ASP A . n 
A 1 177 SER 177 373 373 SER SER A . n 
A 1 178 ASP 178 374 374 ASP ASP A . n 
A 1 179 ILE 179 375 375 ILE ILE A . n 
A 1 180 SER 180 376 376 SER SER A . n 
A 1 181 LEU 181 377 377 LEU LEU A . n 
A 1 182 PHE 182 378 378 PHE PHE A . n 
A 1 183 VAL 183 379 379 VAL VAL A . n 
A 1 184 ALA 184 380 380 ALA ALA A . n 
A 1 185 ALA 185 381 381 ALA ALA A . n 
A 1 186 ILE 186 382 382 ILE ILE A . n 
A 1 187 ILE 187 383 383 ILE ILE A . n 
A 1 188 CYS 188 384 384 CYS CYS A . n 
A 1 189 CYS 189 385 385 CYS CYS A . n 
A 1 190 GLY 190 386 386 GLY GLY A . n 
A 1 191 ASP 191 387 387 ASP ASP A . n 
A 1 192 ARG 192 388 388 ARG ARG A . n 
A 1 193 PRO 193 389 389 PRO PRO A . n 
A 1 194 GLY 194 390 390 GLY GLY A . n 
A 1 195 LEU 195 391 391 LEU LEU A . n 
A 1 196 LEU 196 392 392 LEU LEU A . n 
A 1 197 ASN 197 393 393 ASN ASN A . n 
A 1 198 VAL 198 394 394 VAL VAL A . n 
A 1 199 GLY 199 395 395 GLY GLY A . n 
A 1 200 HIS 200 396 396 HIS HIS A . n 
A 1 201 ILE 201 397 397 ILE ILE A . n 
A 1 202 GLU 202 398 398 GLU GLU A . n 
A 1 203 LYS 203 399 399 LYS LYS A . n 
A 1 204 MET 204 400 400 MET MET A . n 
A 1 205 GLN 205 401 401 GLN GLN A . n 
A 1 206 GLU 206 402 402 GLU GLU A . n 
A 1 207 GLY 207 403 403 GLY GLY A . n 
A 1 208 ILE 208 404 404 ILE ILE A . n 
A 1 209 VAL 209 405 405 VAL VAL A . n 
A 1 210 HIS 210 406 406 HIS HIS A . n 
A 1 211 VAL 211 407 407 VAL VAL A . n 
A 1 212 LEU 212 408 408 LEU LEU A . n 
A 1 213 ARG 213 409 409 ARG ARG A . n 
A 1 214 LEU 214 410 410 LEU LEU A . n 
A 1 215 HIS 215 411 411 HIS HIS A . n 
A 1 216 LEU 216 412 412 LEU LEU A . n 
A 1 217 GLN 217 413 413 GLN GLN A . n 
A 1 218 SER 218 414 414 SER SER A . n 
A 1 219 ASN 219 415 415 ASN ASN A . n 
A 1 220 HIS 220 416 416 HIS HIS A . n 
A 1 221 PRO 221 417 417 PRO PRO A . n 
A 1 222 ASP 222 418 418 ASP ASP A . n 
A 1 223 ASP 223 419 419 ASP ASP A . n 
A 1 224 ILE 224 420 420 ILE ILE A . n 
A 1 225 PHE 225 421 421 PHE PHE A . n 
A 1 226 LEU 226 422 422 LEU LEU A . n 
A 1 227 PHE 227 423 423 PHE PHE A . n 
A 1 228 PRO 228 424 424 PRO PRO A . n 
A 1 229 LYS 229 425 425 LYS LYS A . n 
A 1 230 LEU 230 426 426 LEU LEU A . n 
A 1 231 LEU 231 427 427 LEU LEU A . n 
A 1 232 GLN 232 428 428 GLN GLN A . n 
A 1 233 LYS 233 429 429 LYS LYS A . n 
A 1 234 MET 234 430 430 MET MET A . n 
A 1 235 ALA 235 431 431 ALA ALA A . n 
A 1 236 ASP 236 432 432 ASP ASP A . n 
A 1 237 LEU 237 433 433 LEU LEU A . n 
A 1 238 ARG 238 434 434 ARG ARG A . n 
A 1 239 GLN 239 435 435 GLN GLN A . n 
A 1 240 LEU 240 436 436 LEU LEU A . n 
A 1 241 VAL 241 437 437 VAL VAL A . n 
A 1 242 THR 242 438 438 THR THR A . n 
A 1 243 GLU 243 439 439 GLU GLU A . n 
A 1 244 HIS 244 440 440 HIS HIS A . n 
A 1 245 ALA 245 441 441 ALA ALA A . n 
A 1 246 GLN 246 442 442 GLN GLN A . n 
A 1 247 LEU 247 443 443 LEU LEU A . n 
A 1 248 VAL 248 444 444 VAL VAL A . n 
A 1 249 GLN 249 445 445 GLN GLN A . n 
A 1 250 ILE 250 446 446 ILE ILE A . n 
A 1 251 ILE 251 447 447 ILE ILE A . n 
A 1 252 LYS 252 448 448 LYS LYS A . n 
A 1 253 LYS 253 449 449 LYS LYS A . n 
A 1 254 THR 254 450 450 THR THR A . n 
A 1 255 GLU 255 451 451 GLU GLU A . n 
A 1 256 SER 256 452 452 SER SER A . n 
A 1 257 ASP 257 453 453 ASP ASP A . n 
A 1 258 ALA 258 454 454 ALA ALA A . n 
A 1 259 ALA 259 455 455 ALA ALA A . n 
A 1 260 LEU 260 456 456 LEU LEU A . n 
A 1 261 HIS 261 457 457 HIS HIS A . n 
A 1 262 PRO 262 458 458 PRO PRO A . n 
A 1 263 LEU 263 459 459 LEU LEU A . n 
A 1 264 LEU 264 460 460 LEU LEU A . n 
A 1 265 GLN 265 461 461 GLN GLN A . n 
A 1 266 GLU 266 462 462 GLU GLU A . n 
A 1 267 ILE 267 463 463 ILE ILE A . n 
A 1 268 TYR 268 464 464 TYR TYR A . n 
A 1 269 ARG 269 465 465 ARG ARG A . n 
A 1 270 ASP 270 466 466 ASP ASP A . n 
A 1 271 MET 271 467 467 MET MET A . n 
A 1 272 TYR 272 468 ?   ?   ?   A . n 
B 2 1   PRO 1   135 ?   ?   ?   B . n 
B 2 2   GLN 2   136 ?   ?   ?   B . n 
B 2 3   GLU 3   137 ?   ?   ?   B . n 
B 2 4   ALA 4   138 ?   ?   ?   B . n 
B 2 5   GLU 5   139 ?   ?   ?   B . n 
B 2 6   GLU 6   140 ?   ?   ?   B . n 
B 2 7   PRO 7   141 141 PRO PRO B . n 
B 2 8   SER 8   142 142 SER SER B . n 
B 2 9   LEU 9   143 143 LEU LEU B . n 
B 2 10  LEU 10  144 144 LEU LEU B . n 
B 2 11  LYS 11  145 145 LYS LYS B . n 
B 2 12  LYS 12  146 146 LYS LYS B . n 
B 2 13  LEU 13  147 147 LEU LEU B . n 
B 2 14  LEU 14  148 148 LEU LEU B . n 
B 2 15  LEU 15  149 149 LEU LEU B . n 
B 2 16  ALA 16  150 150 ALA ALA B . n 
B 2 17  PRO 17  151 ?   ?   ?   B . n 
B 2 18  ALA 18  152 ?   ?   ?   B . n 
B 2 19  ASN 19  153 ?   ?   ?   B . n 
B 2 20  THR 20  154 ?   ?   ?   B . n 
B 2 21  GLN 21  155 ?   ?   ?   B . n 
B 2 22  LEU 22  156 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 A1LZ0 ? ? A1LZ0 ? ? 'SUBJECT OF INVESTIGATION' ? 
2 PGO   ? ? PGO   ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 PGO   1   501 501 PGO   PGO A . 
D 4 A1LZ0 1   502 500 A1LZ0 A07 A . 
E 5 HOH   1   601 76  HOH   HOH A . 
E 5 HOH   2   602 108 HOH   HOH A . 
E 5 HOH   3   603 104 HOH   HOH A . 
E 5 HOH   4   604 33  HOH   HOH A . 
E 5 HOH   5   605 39  HOH   HOH A . 
E 5 HOH   6   606 16  HOH   HOH A . 
E 5 HOH   7   607 74  HOH   HOH A . 
E 5 HOH   8   608 107 HOH   HOH A . 
E 5 HOH   9   609 19  HOH   HOH A . 
E 5 HOH   10  610 29  HOH   HOH A . 
E 5 HOH   11  611 37  HOH   HOH A . 
E 5 HOH   12  612 6   HOH   HOH A . 
E 5 HOH   13  613 110 HOH   HOH A . 
E 5 HOH   14  614 72  HOH   HOH A . 
E 5 HOH   15  615 32  HOH   HOH A . 
E 5 HOH   16  616 36  HOH   HOH A . 
E 5 HOH   17  617 20  HOH   HOH A . 
E 5 HOH   18  618 47  HOH   HOH A . 
E 5 HOH   19  619 62  HOH   HOH A . 
E 5 HOH   20  620 54  HOH   HOH A . 
E 5 HOH   21  621 15  HOH   HOH A . 
E 5 HOH   22  622 30  HOH   HOH A . 
E 5 HOH   23  623 69  HOH   HOH A . 
E 5 HOH   24  624 52  HOH   HOH A . 
E 5 HOH   25  625 48  HOH   HOH A . 
E 5 HOH   26  626 45  HOH   HOH A . 
E 5 HOH   27  627 28  HOH   HOH A . 
E 5 HOH   28  628 40  HOH   HOH A . 
E 5 HOH   29  629 8   HOH   HOH A . 
E 5 HOH   30  630 81  HOH   HOH A . 
E 5 HOH   31  631 14  HOH   HOH A . 
E 5 HOH   32  632 23  HOH   HOH A . 
E 5 HOH   33  633 21  HOH   HOH A . 
E 5 HOH   34  634 87  HOH   HOH A . 
E 5 HOH   35  635 35  HOH   HOH A . 
E 5 HOH   36  636 41  HOH   HOH A . 
E 5 HOH   37  637 4   HOH   HOH A . 
E 5 HOH   38  638 12  HOH   HOH A . 
E 5 HOH   39  639 27  HOH   HOH A . 
E 5 HOH   40  640 22  HOH   HOH A . 
E 5 HOH   41  641 1   HOH   HOH A . 
E 5 HOH   42  642 68  HOH   HOH A . 
E 5 HOH   43  643 2   HOH   HOH A . 
E 5 HOH   44  644 90  HOH   HOH A . 
E 5 HOH   45  645 11  HOH   HOH A . 
E 5 HOH   46  646 5   HOH   HOH A . 
E 5 HOH   47  647 10  HOH   HOH A . 
E 5 HOH   48  648 63  HOH   HOH A . 
E 5 HOH   49  649 80  HOH   HOH A . 
E 5 HOH   50  650 3   HOH   HOH A . 
E 5 HOH   51  651 106 HOH   HOH A . 
E 5 HOH   52  652 102 HOH   HOH A . 
E 5 HOH   53  653 89  HOH   HOH A . 
E 5 HOH   54  654 26  HOH   HOH A . 
E 5 HOH   55  655 82  HOH   HOH A . 
E 5 HOH   56  656 75  HOH   HOH A . 
E 5 HOH   57  657 7   HOH   HOH A . 
E 5 HOH   58  658 78  HOH   HOH A . 
E 5 HOH   59  659 66  HOH   HOH A . 
E 5 HOH   60  660 38  HOH   HOH A . 
E 5 HOH   61  661 92  HOH   HOH A . 
E 5 HOH   62  662 43  HOH   HOH A . 
E 5 HOH   63  663 61  HOH   HOH A . 
E 5 HOH   64  664 71  HOH   HOH A . 
E 5 HOH   65  665 97  HOH   HOH A . 
E 5 HOH   66  666 70  HOH   HOH A . 
E 5 HOH   67  667 9   HOH   HOH A . 
E 5 HOH   68  668 91  HOH   HOH A . 
E 5 HOH   69  669 84  HOH   HOH A . 
E 5 HOH   70  670 17  HOH   HOH A . 
E 5 HOH   71  671 112 HOH   HOH A . 
E 5 HOH   72  672 96  HOH   HOH A . 
E 5 HOH   73  673 53  HOH   HOH A . 
E 5 HOH   74  674 58  HOH   HOH A . 
E 5 HOH   75  675 13  HOH   HOH A . 
E 5 HOH   76  676 25  HOH   HOH A . 
E 5 HOH   77  677 46  HOH   HOH A . 
E 5 HOH   78  678 64  HOH   HOH A . 
E 5 HOH   79  679 103 HOH   HOH A . 
E 5 HOH   80  680 105 HOH   HOH A . 
E 5 HOH   81  681 56  HOH   HOH A . 
E 5 HOH   82  682 111 HOH   HOH A . 
E 5 HOH   83  683 67  HOH   HOH A . 
E 5 HOH   84  684 73  HOH   HOH A . 
E 5 HOH   85  685 109 HOH   HOH A . 
E 5 HOH   86  686 49  HOH   HOH A . 
E 5 HOH   87  687 60  HOH   HOH A . 
E 5 HOH   88  688 55  HOH   HOH A . 
E 5 HOH   89  689 85  HOH   HOH A . 
E 5 HOH   90  690 113 HOH   HOH A . 
E 5 HOH   91  691 100 HOH   HOH A . 
E 5 HOH   92  692 93  HOH   HOH A . 
E 5 HOH   93  693 99  HOH   HOH A . 
E 5 HOH   94  694 94  HOH   HOH A . 
E 5 HOH   95  695 24  HOH   HOH A . 
E 5 HOH   96  696 31  HOH   HOH A . 
E 5 HOH   97  697 79  HOH   HOH A . 
E 5 HOH   98  698 98  HOH   HOH A . 
E 5 HOH   99  699 34  HOH   HOH A . 
E 5 HOH   100 700 59  HOH   HOH A . 
E 5 HOH   101 701 88  HOH   HOH A . 
E 5 HOH   102 702 77  HOH   HOH A . 
E 5 HOH   103 703 42  HOH   HOH A . 
E 5 HOH   104 704 83  HOH   HOH A . 
E 5 HOH   105 705 44  HOH   HOH A . 
E 5 HOH   106 706 57  HOH   HOH A . 
E 5 HOH   107 707 101 HOH   HOH A . 
E 5 HOH   108 708 18  HOH   HOH A . 
E 5 HOH   109 709 95  HOH   HOH A . 
F 5 HOH   1   201 65  HOH   HOH B . 
F 5 HOH   2   202 50  HOH   HOH B . 
F 5 HOH   3   203 51  HOH   HOH B . 
F 5 HOH   4   204 86  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YTL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.395 
_cell.length_a_esd                 ? 
_cell.length_b                     61.344 
_cell.length_b_esd                 ? 
_cell.length_c                     100.906 
_cell.length_c_esd                 ? 
_cell.volume                       280994.036 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YTL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YTL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.12 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.06 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES-NaOH, 19-23% PEG 4000, 19-23% 1,2-propanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-07-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL26B1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL26B1 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          37.10 
_reflns.entry_id                                       8YTL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               45.40 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     19751 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.112 
_reflns.pdbx_Rpim_I_all                                0.036 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       179963 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.106 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.05 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           13948 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1448 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               9.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.5 
_reflns_shell.pdbx_Rrim_I_all                               1.656 
_reflns_shell.pdbx_Rpim_I_all                               0.516 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.585 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.570 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               41.12 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YTL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             41.40 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     19700 
_refine.ls_number_reflns_R_free                  2007 
_refine.ls_number_reflns_R_work                  17693 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.96 
_refine.ls_percent_reflns_R_free                 10.19 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2302 
_refine.ls_R_factor_R_free                       0.2603 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2268 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.6821 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2819 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        41.40 
_refine_hist.number_atoms_solvent             113 
_refine_hist.number_atoms_total               2248 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2093 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         42 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0020  ? 2175 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.4972  ? 2930 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0337  ? 338  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0022  ? 362  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 21.1623 ? 291  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.05  . . 135 1259 100.00 . . . . 0.3439 . . . . . . . . . . . 0.4107 
'X-RAY DIFFRACTION' 2.05 2.11  . . 156 1213 100.00 . . . . 0.3005 . . . . . . . . . . . 0.3288 
'X-RAY DIFFRACTION' 2.11 2.17  . . 139 1249 100.00 . . . . 0.2938 . . . . . . . . . . . 0.3664 
'X-RAY DIFFRACTION' 2.17 2.24  . . 153 1225 100.00 . . . . 0.2643 . . . . . . . . . . . 0.3013 
'X-RAY DIFFRACTION' 2.24 2.32  . . 125 1253 100.00 . . . . 0.2583 . . . . . . . . . . . 0.2776 
'X-RAY DIFFRACTION' 2.32 2.41  . . 139 1265 100.00 . . . . 0.2415 . . . . . . . . . . . 0.2761 
'X-RAY DIFFRACTION' 2.41 2.52  . . 136 1257 100.00 . . . . 0.2489 . . . . . . . . . . . 0.3067 
'X-RAY DIFFRACTION' 2.52 2.65  . . 156 1234 99.93  . . . . 0.2590 . . . . . . . . . . . 0.3319 
'X-RAY DIFFRACTION' 2.65 2.82  . . 135 1268 100.00 . . . . 0.2384 . . . . . . . . . . . 0.2952 
'X-RAY DIFFRACTION' 2.82 3.04  . . 152 1246 100.00 . . . . 0.2557 . . . . . . . . . . . 0.3066 
'X-RAY DIFFRACTION' 3.04 3.34  . . 144 1254 99.79  . . . . 0.2461 . . . . . . . . . . . 0.2895 
'X-RAY DIFFRACTION' 3.34 3.82  . . 148 1294 100.00 . . . . 0.2102 . . . . . . . . . . . 0.2195 
'X-RAY DIFFRACTION' 3.83 4.82  . . 146 1293 99.93  . . . . 0.1831 . . . . . . . . . . . 0.2235 
'X-RAY DIFFRACTION' 4.82 41.40 . . 143 1383 99.80  . . . . 0.2018 . . . . . . . . . . . 0.1996 
# 
_struct.entry_id                     8YTL 
_struct.title                        
'Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YTL 
_struct_keywords.text            'Agonist, Complex, Nuclear receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARA_HUMAN Q07869 ? 1 
;TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
;
200 
2 UNP PRGC1_HUMAN Q9UBK2 ? 2 PQEAEEPSLLKKLLLAPANTQL 135 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YTL A 4 ? 272 ? Q07869 200 ? 468 ? 200 468 
2 2 8YTL B 1 ? 22  ? Q9UBK2 135 ? 156 ? 135 156 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YTL GLY A 1 ? UNP Q07869 ? ? 'expression tag' 197 1 
1 8YTL GLY A 2 ? UNP Q07869 ? ? 'expression tag' 198 2 
1 8YTL GLN A 3 ? UNP Q07869 ? ? 'expression tag' 199 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? PHE A 22  ? SER A 205 PHE A 218 1 ? 14 
HELX_P HELX_P2  AA2 ASN A 25  ? SER A 34  ? ASN A 221 SER A 230 1 ? 10 
HELX_P HELX_P3  AA3 ASP A 47  ? VAL A 59  ? ASP A 243 VAL A 255 1 ? 13 
HELX_P HELX_P4  AA4 GLU A 71  ? ALA A 97  ? GLU A 267 ALA A 293 1 ? 27 
HELX_P HELX_P5  AA5 ASP A 105 ? SER A 126 ? ASP A 301 SER A 322 1 ? 22 
HELX_P HELX_P6  AA6 SER A 127 ? MET A 129 ? SER A 323 MET A 325 5 ? 3  
HELX_P HELX_P7  AA7 ARG A 145 ? SER A 150 ? ARG A 341 SER A 346 1 ? 6  
HELX_P HELX_P8  AA8 PRO A 154 ? ILE A 158 ? PRO A 350 ILE A 354 5 ? 5  
HELX_P HELX_P9  AA9 MET A 159 ? ALA A 171 ? MET A 355 ALA A 367 1 ? 13 
HELX_P HELX_P10 AB1 ASP A 175 ? CYS A 188 ? ASP A 371 CYS A 384 1 ? 14 
HELX_P HELX_P11 AB2 ASN A 197 ? HIS A 220 ? ASN A 393 HIS A 416 1 ? 24 
HELX_P HELX_P12 AB3 PHE A 225 ? GLU A 255 ? PHE A 421 GLU A 451 1 ? 31 
HELX_P HELX_P13 AB4 HIS A 261 ? ARG A 269 ? HIS A 457 ARG A 465 1 ? 9  
HELX_P HELX_P14 AB5 SER B 8   ? LEU B 15  ? SER B 142 LEU B 149 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           153 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            349 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    154 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     350 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.87 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 43  ? ILE A 45  ? PHE A 239 ILE A 241 
AA1 2 GLY A 141 ? THR A 144 ? GLY A 337 THR A 340 
AA1 3 GLY A 133 ? VAL A 136 ? GLY A 329 VAL A 332 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 45  ? N ILE A 241 O PHE A 142 ? O PHE A 338 
AA1 2 3 O GLY A 141 ? O GLY A 337 N VAL A 136 ? N VAL A 332 
# 
_pdbx_entry_details.entry_id                   8YTL 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    LEU 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     392 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -92.82 
_pdbx_validate_torsion.psi             -66.38 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 197 ? A GLY 1   
2  1 Y 1 A GLY 198 ? A GLY 2   
3  1 Y 1 A GLN 199 ? A GLN 3   
4  1 Y 1 A THR 200 ? A THR 4   
5  1 Y 1 A ALA 201 ? A ALA 5   
6  1 Y 1 A GLY 231 ? A GLY 35  
7  1 Y 1 A LYS 232 ? A LYS 36  
8  1 Y 1 A ALA 233 ? A ALA 37  
9  1 Y 1 A SER 234 ? A SER 38  
10 1 Y 1 A ASN 235 ? A ASN 39  
11 1 Y 1 A ASN 236 ? A ASN 40  
12 1 Y 1 A PRO 237 ? A PRO 41  
13 1 Y 1 A VAL 259 ? A VAL 63  
14 1 Y 1 A ALA 260 ? A ALA 64  
15 1 Y 1 A ASN 261 ? A ASN 65  
16 1 Y 1 A GLY 262 ? A GLY 66  
17 1 Y 1 A ILE 263 ? A ILE 67  
18 1 Y 1 A GLN 264 ? A GLN 68  
19 1 Y 1 A TYR 468 ? A TYR 272 
20 1 Y 1 B PRO 135 ? B PRO 1   
21 1 Y 1 B GLN 136 ? B GLN 2   
22 1 Y 1 B GLU 137 ? B GLU 3   
23 1 Y 1 B ALA 138 ? B ALA 4   
24 1 Y 1 B GLU 139 ? B GLU 5   
25 1 Y 1 B GLU 140 ? B GLU 6   
26 1 Y 1 B PRO 151 ? B PRO 17  
27 1 Y 1 B ALA 152 ? B ALA 18  
28 1 Y 1 B ASN 153 ? B ASN 19  
29 1 Y 1 B THR 154 ? B THR 20  
30 1 Y 1 B GLN 155 ? B GLN 21  
31 1 Y 1 B LEU 156 ? B LEU 22  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LZ0 C12  C N N 1   
A1LZ0 C13  C N N 2   
A1LZ0 C14  C Y N 3   
A1LZ0 C15  C Y N 4   
A1LZ0 C16  C Y N 5   
A1LZ0 C17  C Y N 6   
A1LZ0 N21  N Y N 7   
A1LZ0 N23  N Y N 8   
A1LZ0 C26  C N N 9   
A1LZ0 C29  C N N 10  
A1LZ0 C01  C Y N 11  
A1LZ0 C02  C Y N 12  
A1LZ0 C03  C Y N 13  
A1LZ0 C04  C Y N 14  
A1LZ0 C05  C Y N 15  
A1LZ0 C06  C Y N 16  
A1LZ0 C08  C N N 17  
A1LZ0 C09  C N N 18  
A1LZ0 C10  C N N 19  
A1LZ0 C11  C N N 20  
A1LZ0 C18  C Y N 21  
A1LZ0 C19  C Y N 22  
A1LZ0 C27  C N N 23  
A1LZ0 C28  C N N 24  
A1LZ0 C31  C N N 25  
A1LZ0 C32  C N N 26  
A1LZ0 C35  C N N 27  
A1LZ0 C36  C N N 28  
A1LZ0 C37  C N N 29  
A1LZ0 F20  F N N 30  
A1LZ0 N07  N N N 31  
A1LZ0 N22  N Y N 32  
A1LZ0 N30  N N N 33  
A1LZ0 O24  O N N 34  
A1LZ0 O25  O N N 35  
A1LZ0 O33  O N N 36  
A1LZ0 O34  O N N 37  
A1LZ0 H1   H N N 38  
A1LZ0 H2   H N N 39  
A1LZ0 H3   H N N 40  
A1LZ0 H4   H N N 41  
A1LZ0 H5   H N N 42  
A1LZ0 H6   H N N 43  
A1LZ0 H7   H N N 44  
A1LZ0 H8   H N N 45  
A1LZ0 H9   H N N 46  
A1LZ0 H10  H N N 47  
A1LZ0 H11  H N N 48  
A1LZ0 H12  H N N 49  
A1LZ0 H13  H N N 50  
A1LZ0 H14  H N N 51  
A1LZ0 H15  H N N 52  
A1LZ0 H16  H N N 53  
A1LZ0 H17  H N N 54  
A1LZ0 H18  H N N 55  
A1LZ0 H19  H N N 56  
A1LZ0 H20  H N N 57  
A1LZ0 H21  H N N 58  
A1LZ0 H22  H N N 59  
A1LZ0 H23  H N N 60  
A1LZ0 H24  H N N 61  
A1LZ0 H25  H N N 62  
A1LZ0 H26  H N N 63  
A1LZ0 H27  H N N 64  
A1LZ0 H28  H N N 65  
A1LZ0 H29  H N N 66  
A1LZ0 H30  H N N 67  
A1LZ0 H31  H N N 68  
A1LZ0 H32  H N N 69  
A1LZ0 H33  H N N 70  
A1LZ0 H34  H N N 71  
ALA   N    N N N 72  
ALA   CA   C N S 73  
ALA   C    C N N 74  
ALA   O    O N N 75  
ALA   CB   C N N 76  
ALA   OXT  O N N 77  
ALA   H    H N N 78  
ALA   H2   H N N 79  
ALA   HA   H N N 80  
ALA   HB1  H N N 81  
ALA   HB2  H N N 82  
ALA   HB3  H N N 83  
ALA   HXT  H N N 84  
ARG   N    N N N 85  
ARG   CA   C N S 86  
ARG   C    C N N 87  
ARG   O    O N N 88  
ARG   CB   C N N 89  
ARG   CG   C N N 90  
ARG   CD   C N N 91  
ARG   NE   N N N 92  
ARG   CZ   C N N 93  
ARG   NH1  N N N 94  
ARG   NH2  N N N 95  
ARG   OXT  O N N 96  
ARG   H    H N N 97  
ARG   H2   H N N 98  
ARG   HA   H N N 99  
ARG   HB2  H N N 100 
ARG   HB3  H N N 101 
ARG   HG2  H N N 102 
ARG   HG3  H N N 103 
ARG   HD2  H N N 104 
ARG   HD3  H N N 105 
ARG   HE   H N N 106 
ARG   HH11 H N N 107 
ARG   HH12 H N N 108 
ARG   HH21 H N N 109 
ARG   HH22 H N N 110 
ARG   HXT  H N N 111 
ASN   N    N N N 112 
ASN   CA   C N S 113 
ASN   C    C N N 114 
ASN   O    O N N 115 
ASN   CB   C N N 116 
ASN   CG   C N N 117 
ASN   OD1  O N N 118 
ASN   ND2  N N N 119 
ASN   OXT  O N N 120 
ASN   H    H N N 121 
ASN   H2   H N N 122 
ASN   HA   H N N 123 
ASN   HB2  H N N 124 
ASN   HB3  H N N 125 
ASN   HD21 H N N 126 
ASN   HD22 H N N 127 
ASN   HXT  H N N 128 
ASP   N    N N N 129 
ASP   CA   C N S 130 
ASP   C    C N N 131 
ASP   O    O N N 132 
ASP   CB   C N N 133 
ASP   CG   C N N 134 
ASP   OD1  O N N 135 
ASP   OD2  O N N 136 
ASP   OXT  O N N 137 
ASP   H    H N N 138 
ASP   H2   H N N 139 
ASP   HA   H N N 140 
ASP   HB2  H N N 141 
ASP   HB3  H N N 142 
ASP   HD2  H N N 143 
ASP   HXT  H N N 144 
CYS   N    N N N 145 
CYS   CA   C N R 146 
CYS   C    C N N 147 
CYS   O    O N N 148 
CYS   CB   C N N 149 
CYS   SG   S N N 150 
CYS   OXT  O N N 151 
CYS   H    H N N 152 
CYS   H2   H N N 153 
CYS   HA   H N N 154 
CYS   HB2  H N N 155 
CYS   HB3  H N N 156 
CYS   HG   H N N 157 
CYS   HXT  H N N 158 
GLN   N    N N N 159 
GLN   CA   C N S 160 
GLN   C    C N N 161 
GLN   O    O N N 162 
GLN   CB   C N N 163 
GLN   CG   C N N 164 
GLN   CD   C N N 165 
GLN   OE1  O N N 166 
GLN   NE2  N N N 167 
GLN   OXT  O N N 168 
GLN   H    H N N 169 
GLN   H2   H N N 170 
GLN   HA   H N N 171 
GLN   HB2  H N N 172 
GLN   HB3  H N N 173 
GLN   HG2  H N N 174 
GLN   HG3  H N N 175 
GLN   HE21 H N N 176 
GLN   HE22 H N N 177 
GLN   HXT  H N N 178 
GLU   N    N N N 179 
GLU   CA   C N S 180 
GLU   C    C N N 181 
GLU   O    O N N 182 
GLU   CB   C N N 183 
GLU   CG   C N N 184 
GLU   CD   C N N 185 
GLU   OE1  O N N 186 
GLU   OE2  O N N 187 
GLU   OXT  O N N 188 
GLU   H    H N N 189 
GLU   H2   H N N 190 
GLU   HA   H N N 191 
GLU   HB2  H N N 192 
GLU   HB3  H N N 193 
GLU   HG2  H N N 194 
GLU   HG3  H N N 195 
GLU   HE2  H N N 196 
GLU   HXT  H N N 197 
GLY   N    N N N 198 
GLY   CA   C N N 199 
GLY   C    C N N 200 
GLY   O    O N N 201 
GLY   OXT  O N N 202 
GLY   H    H N N 203 
GLY   H2   H N N 204 
GLY   HA2  H N N 205 
GLY   HA3  H N N 206 
GLY   HXT  H N N 207 
HIS   N    N N N 208 
HIS   CA   C N S 209 
HIS   C    C N N 210 
HIS   O    O N N 211 
HIS   CB   C N N 212 
HIS   CG   C Y N 213 
HIS   ND1  N Y N 214 
HIS   CD2  C Y N 215 
HIS   CE1  C Y N 216 
HIS   NE2  N Y N 217 
HIS   OXT  O N N 218 
HIS   H    H N N 219 
HIS   H2   H N N 220 
HIS   HA   H N N 221 
HIS   HB2  H N N 222 
HIS   HB3  H N N 223 
HIS   HD1  H N N 224 
HIS   HD2  H N N 225 
HIS   HE1  H N N 226 
HIS   HE2  H N N 227 
HIS   HXT  H N N 228 
HOH   O    O N N 229 
HOH   H1   H N N 230 
HOH   H2   H N N 231 
ILE   N    N N N 232 
ILE   CA   C N S 233 
ILE   C    C N N 234 
ILE   O    O N N 235 
ILE   CB   C N S 236 
ILE   CG1  C N N 237 
ILE   CG2  C N N 238 
ILE   CD1  C N N 239 
ILE   OXT  O N N 240 
ILE   H    H N N 241 
ILE   H2   H N N 242 
ILE   HA   H N N 243 
ILE   HB   H N N 244 
ILE   HG12 H N N 245 
ILE   HG13 H N N 246 
ILE   HG21 H N N 247 
ILE   HG22 H N N 248 
ILE   HG23 H N N 249 
ILE   HD11 H N N 250 
ILE   HD12 H N N 251 
ILE   HD13 H N N 252 
ILE   HXT  H N N 253 
LEU   N    N N N 254 
LEU   CA   C N S 255 
LEU   C    C N N 256 
LEU   O    O N N 257 
LEU   CB   C N N 258 
LEU   CG   C N N 259 
LEU   CD1  C N N 260 
LEU   CD2  C N N 261 
LEU   OXT  O N N 262 
LEU   H    H N N 263 
LEU   H2   H N N 264 
LEU   HA   H N N 265 
LEU   HB2  H N N 266 
LEU   HB3  H N N 267 
LEU   HG   H N N 268 
LEU   HD11 H N N 269 
LEU   HD12 H N N 270 
LEU   HD13 H N N 271 
LEU   HD21 H N N 272 
LEU   HD22 H N N 273 
LEU   HD23 H N N 274 
LEU   HXT  H N N 275 
LYS   N    N N N 276 
LYS   CA   C N S 277 
LYS   C    C N N 278 
LYS   O    O N N 279 
LYS   CB   C N N 280 
LYS   CG   C N N 281 
LYS   CD   C N N 282 
LYS   CE   C N N 283 
LYS   NZ   N N N 284 
LYS   OXT  O N N 285 
LYS   H    H N N 286 
LYS   H2   H N N 287 
LYS   HA   H N N 288 
LYS   HB2  H N N 289 
LYS   HB3  H N N 290 
LYS   HG2  H N N 291 
LYS   HG3  H N N 292 
LYS   HD2  H N N 293 
LYS   HD3  H N N 294 
LYS   HE2  H N N 295 
LYS   HE3  H N N 296 
LYS   HZ1  H N N 297 
LYS   HZ2  H N N 298 
LYS   HZ3  H N N 299 
LYS   HXT  H N N 300 
MET   N    N N N 301 
MET   CA   C N S 302 
MET   C    C N N 303 
MET   O    O N N 304 
MET   CB   C N N 305 
MET   CG   C N N 306 
MET   SD   S N N 307 
MET   CE   C N N 308 
MET   OXT  O N N 309 
MET   H    H N N 310 
MET   H2   H N N 311 
MET   HA   H N N 312 
MET   HB2  H N N 313 
MET   HB3  H N N 314 
MET   HG2  H N N 315 
MET   HG3  H N N 316 
MET   HE1  H N N 317 
MET   HE2  H N N 318 
MET   HE3  H N N 319 
MET   HXT  H N N 320 
PGO   C1   C N N 321 
PGO   C2   C N S 322 
PGO   C3   C N N 323 
PGO   O1   O N N 324 
PGO   O2   O N N 325 
PGO   H11  H N N 326 
PGO   H12  H N N 327 
PGO   H2   H N N 328 
PGO   H31  H N N 329 
PGO   H32  H N N 330 
PGO   H33  H N N 331 
PGO   HO1  H N N 332 
PGO   HO2  H N N 333 
PHE   N    N N N 334 
PHE   CA   C N S 335 
PHE   C    C N N 336 
PHE   O    O N N 337 
PHE   CB   C N N 338 
PHE   CG   C Y N 339 
PHE   CD1  C Y N 340 
PHE   CD2  C Y N 341 
PHE   CE1  C Y N 342 
PHE   CE2  C Y N 343 
PHE   CZ   C Y N 344 
PHE   OXT  O N N 345 
PHE   H    H N N 346 
PHE   H2   H N N 347 
PHE   HA   H N N 348 
PHE   HB2  H N N 349 
PHE   HB3  H N N 350 
PHE   HD1  H N N 351 
PHE   HD2  H N N 352 
PHE   HE1  H N N 353 
PHE   HE2  H N N 354 
PHE   HZ   H N N 355 
PHE   HXT  H N N 356 
PRO   N    N N N 357 
PRO   CA   C N S 358 
PRO   C    C N N 359 
PRO   O    O N N 360 
PRO   CB   C N N 361 
PRO   CG   C N N 362 
PRO   CD   C N N 363 
PRO   OXT  O N N 364 
PRO   H    H N N 365 
PRO   HA   H N N 366 
PRO   HB2  H N N 367 
PRO   HB3  H N N 368 
PRO   HG2  H N N 369 
PRO   HG3  H N N 370 
PRO   HD2  H N N 371 
PRO   HD3  H N N 372 
PRO   HXT  H N N 373 
SER   N    N N N 374 
SER   CA   C N S 375 
SER   C    C N N 376 
SER   O    O N N 377 
SER   CB   C N N 378 
SER   OG   O N N 379 
SER   OXT  O N N 380 
SER   H    H N N 381 
SER   H2   H N N 382 
SER   HA   H N N 383 
SER   HB2  H N N 384 
SER   HB3  H N N 385 
SER   HG   H N N 386 
SER   HXT  H N N 387 
THR   N    N N N 388 
THR   CA   C N S 389 
THR   C    C N N 390 
THR   O    O N N 391 
THR   CB   C N R 392 
THR   OG1  O N N 393 
THR   CG2  C N N 394 
THR   OXT  O N N 395 
THR   H    H N N 396 
THR   H2   H N N 397 
THR   HA   H N N 398 
THR   HB   H N N 399 
THR   HG1  H N N 400 
THR   HG21 H N N 401 
THR   HG22 H N N 402 
THR   HG23 H N N 403 
THR   HXT  H N N 404 
TYR   N    N N N 405 
TYR   CA   C N S 406 
TYR   C    C N N 407 
TYR   O    O N N 408 
TYR   CB   C N N 409 
TYR   CG   C Y N 410 
TYR   CD1  C Y N 411 
TYR   CD2  C Y N 412 
TYR   CE1  C Y N 413 
TYR   CE2  C Y N 414 
TYR   CZ   C Y N 415 
TYR   OH   O N N 416 
TYR   OXT  O N N 417 
TYR   H    H N N 418 
TYR   H2   H N N 419 
TYR   HA   H N N 420 
TYR   HB2  H N N 421 
TYR   HB3  H N N 422 
TYR   HD1  H N N 423 
TYR   HD2  H N N 424 
TYR   HE1  H N N 425 
TYR   HE2  H N N 426 
TYR   HH   H N N 427 
TYR   HXT  H N N 428 
VAL   N    N N N 429 
VAL   CA   C N S 430 
VAL   C    C N N 431 
VAL   O    O N N 432 
VAL   CB   C N N 433 
VAL   CG1  C N N 434 
VAL   CG2  C N N 435 
VAL   OXT  O N N 436 
VAL   H    H N N 437 
VAL   H2   H N N 438 
VAL   HA   H N N 439 
VAL   HB   H N N 440 
VAL   HG11 H N N 441 
VAL   HG12 H N N 442 
VAL   HG13 H N N 443 
VAL   HG21 H N N 444 
VAL   HG22 H N N 445 
VAL   HG23 H N N 446 
VAL   HXT  H N N 447 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LZ0 C01 C02  doub Y N 1   
A1LZ0 C01 N07  sing N N 2   
A1LZ0 C01 N21  sing Y N 3   
A1LZ0 C02 C03  sing Y N 4   
A1LZ0 C03 C04  doub Y N 5   
A1LZ0 C03 C08  sing N N 6   
A1LZ0 C04 C05  sing Y N 7   
A1LZ0 C04 C06  sing Y N 8   
A1LZ0 C05 N21  doub Y N 9   
A1LZ0 C05 N23  sing Y N 10  
A1LZ0 C06 C09  sing N N 11  
A1LZ0 C06 N22  doub Y N 12  
A1LZ0 C08 O24  doub N N 13  
A1LZ0 C08 O25  sing N N 14  
A1LZ0 C09 C10  sing N N 15  
A1LZ0 C09 C11  sing N N 16  
A1LZ0 C10 C12  sing N N 17  
A1LZ0 C11 C13  sing N N 18  
A1LZ0 C14 C15  doub Y N 19  
A1LZ0 C14 C19  sing Y N 20  
A1LZ0 C15 C16  sing Y N 21  
A1LZ0 C16 C17  doub Y N 22  
A1LZ0 C16 F20  sing N N 23  
A1LZ0 C17 C18  sing Y N 24  
A1LZ0 C18 C19  doub Y N 25  
A1LZ0 C19 N23  sing N N 26  
A1LZ0 N22 N23  sing Y N 27  
A1LZ0 C28 C29  sing N N 28  
A1LZ0 C29 N30  sing N N 29  
A1LZ0 N30 C31  sing N N 30  
A1LZ0 C31 C32  sing N N 31  
A1LZ0 N07 C28  sing N N 32  
A1LZ0 N07 C32  sing N N 33  
A1LZ0 N30 C26  sing N N 34  
A1LZ0 C26 O33  doub N N 35  
A1LZ0 C26 O34  sing N N 36  
A1LZ0 O34 C27  sing N N 37  
A1LZ0 C27 C35  sing N N 38  
A1LZ0 C27 C36  sing N N 39  
A1LZ0 C27 C37  sing N N 40  
A1LZ0 C12 H1   sing N N 41  
A1LZ0 C12 H2   sing N N 42  
A1LZ0 C12 H3   sing N N 43  
A1LZ0 C13 H4   sing N N 44  
A1LZ0 C13 H5   sing N N 45  
A1LZ0 C13 H6   sing N N 46  
A1LZ0 C14 H7   sing N N 47  
A1LZ0 C15 H8   sing N N 48  
A1LZ0 C17 H9   sing N N 49  
A1LZ0 C29 H10  sing N N 50  
A1LZ0 C29 H11  sing N N 51  
A1LZ0 C02 H12  sing N N 52  
A1LZ0 C09 H13  sing N N 53  
A1LZ0 C10 H14  sing N N 54  
A1LZ0 C10 H15  sing N N 55  
A1LZ0 C11 H16  sing N N 56  
A1LZ0 C11 H17  sing N N 57  
A1LZ0 C18 H18  sing N N 58  
A1LZ0 C28 H19  sing N N 59  
A1LZ0 C28 H20  sing N N 60  
A1LZ0 C31 H21  sing N N 61  
A1LZ0 C31 H22  sing N N 62  
A1LZ0 C32 H23  sing N N 63  
A1LZ0 C32 H24  sing N N 64  
A1LZ0 C35 H25  sing N N 65  
A1LZ0 C35 H26  sing N N 66  
A1LZ0 C35 H27  sing N N 67  
A1LZ0 C36 H28  sing N N 68  
A1LZ0 C36 H29  sing N N 69  
A1LZ0 C36 H30  sing N N 70  
A1LZ0 C37 H31  sing N N 71  
A1LZ0 C37 H32  sing N N 72  
A1LZ0 C37 H33  sing N N 73  
A1LZ0 O25 H34  sing N N 74  
ALA   N   CA   sing N N 75  
ALA   N   H    sing N N 76  
ALA   N   H2   sing N N 77  
ALA   CA  C    sing N N 78  
ALA   CA  CB   sing N N 79  
ALA   CA  HA   sing N N 80  
ALA   C   O    doub N N 81  
ALA   C   OXT  sing N N 82  
ALA   CB  HB1  sing N N 83  
ALA   CB  HB2  sing N N 84  
ALA   CB  HB3  sing N N 85  
ALA   OXT HXT  sing N N 86  
ARG   N   CA   sing N N 87  
ARG   N   H    sing N N 88  
ARG   N   H2   sing N N 89  
ARG   CA  C    sing N N 90  
ARG   CA  CB   sing N N 91  
ARG   CA  HA   sing N N 92  
ARG   C   O    doub N N 93  
ARG   C   OXT  sing N N 94  
ARG   CB  CG   sing N N 95  
ARG   CB  HB2  sing N N 96  
ARG   CB  HB3  sing N N 97  
ARG   CG  CD   sing N N 98  
ARG   CG  HG2  sing N N 99  
ARG   CG  HG3  sing N N 100 
ARG   CD  NE   sing N N 101 
ARG   CD  HD2  sing N N 102 
ARG   CD  HD3  sing N N 103 
ARG   NE  CZ   sing N N 104 
ARG   NE  HE   sing N N 105 
ARG   CZ  NH1  sing N N 106 
ARG   CZ  NH2  doub N N 107 
ARG   NH1 HH11 sing N N 108 
ARG   NH1 HH12 sing N N 109 
ARG   NH2 HH21 sing N N 110 
ARG   NH2 HH22 sing N N 111 
ARG   OXT HXT  sing N N 112 
ASN   N   CA   sing N N 113 
ASN   N   H    sing N N 114 
ASN   N   H2   sing N N 115 
ASN   CA  C    sing N N 116 
ASN   CA  CB   sing N N 117 
ASN   CA  HA   sing N N 118 
ASN   C   O    doub N N 119 
ASN   C   OXT  sing N N 120 
ASN   CB  CG   sing N N 121 
ASN   CB  HB2  sing N N 122 
ASN   CB  HB3  sing N N 123 
ASN   CG  OD1  doub N N 124 
ASN   CG  ND2  sing N N 125 
ASN   ND2 HD21 sing N N 126 
ASN   ND2 HD22 sing N N 127 
ASN   OXT HXT  sing N N 128 
ASP   N   CA   sing N N 129 
ASP   N   H    sing N N 130 
ASP   N   H2   sing N N 131 
ASP   CA  C    sing N N 132 
ASP   CA  CB   sing N N 133 
ASP   CA  HA   sing N N 134 
ASP   C   O    doub N N 135 
ASP   C   OXT  sing N N 136 
ASP   CB  CG   sing N N 137 
ASP   CB  HB2  sing N N 138 
ASP   CB  HB3  sing N N 139 
ASP   CG  OD1  doub N N 140 
ASP   CG  OD2  sing N N 141 
ASP   OD2 HD2  sing N N 142 
ASP   OXT HXT  sing N N 143 
CYS   N   CA   sing N N 144 
CYS   N   H    sing N N 145 
CYS   N   H2   sing N N 146 
CYS   CA  C    sing N N 147 
CYS   CA  CB   sing N N 148 
CYS   CA  HA   sing N N 149 
CYS   C   O    doub N N 150 
CYS   C   OXT  sing N N 151 
CYS   CB  SG   sing N N 152 
CYS   CB  HB2  sing N N 153 
CYS   CB  HB3  sing N N 154 
CYS   SG  HG   sing N N 155 
CYS   OXT HXT  sing N N 156 
GLN   N   CA   sing N N 157 
GLN   N   H    sing N N 158 
GLN   N   H2   sing N N 159 
GLN   CA  C    sing N N 160 
GLN   CA  CB   sing N N 161 
GLN   CA  HA   sing N N 162 
GLN   C   O    doub N N 163 
GLN   C   OXT  sing N N 164 
GLN   CB  CG   sing N N 165 
GLN   CB  HB2  sing N N 166 
GLN   CB  HB3  sing N N 167 
GLN   CG  CD   sing N N 168 
GLN   CG  HG2  sing N N 169 
GLN   CG  HG3  sing N N 170 
GLN   CD  OE1  doub N N 171 
GLN   CD  NE2  sing N N 172 
GLN   NE2 HE21 sing N N 173 
GLN   NE2 HE22 sing N N 174 
GLN   OXT HXT  sing N N 175 
GLU   N   CA   sing N N 176 
GLU   N   H    sing N N 177 
GLU   N   H2   sing N N 178 
GLU   CA  C    sing N N 179 
GLU   CA  CB   sing N N 180 
GLU   CA  HA   sing N N 181 
GLU   C   O    doub N N 182 
GLU   C   OXT  sing N N 183 
GLU   CB  CG   sing N N 184 
GLU   CB  HB2  sing N N 185 
GLU   CB  HB3  sing N N 186 
GLU   CG  CD   sing N N 187 
GLU   CG  HG2  sing N N 188 
GLU   CG  HG3  sing N N 189 
GLU   CD  OE1  doub N N 190 
GLU   CD  OE2  sing N N 191 
GLU   OE2 HE2  sing N N 192 
GLU   OXT HXT  sing N N 193 
GLY   N   CA   sing N N 194 
GLY   N   H    sing N N 195 
GLY   N   H2   sing N N 196 
GLY   CA  C    sing N N 197 
GLY   CA  HA2  sing N N 198 
GLY   CA  HA3  sing N N 199 
GLY   C   O    doub N N 200 
GLY   C   OXT  sing N N 201 
GLY   OXT HXT  sing N N 202 
HIS   N   CA   sing N N 203 
HIS   N   H    sing N N 204 
HIS   N   H2   sing N N 205 
HIS   CA  C    sing N N 206 
HIS   CA  CB   sing N N 207 
HIS   CA  HA   sing N N 208 
HIS   C   O    doub N N 209 
HIS   C   OXT  sing N N 210 
HIS   CB  CG   sing N N 211 
HIS   CB  HB2  sing N N 212 
HIS   CB  HB3  sing N N 213 
HIS   CG  ND1  sing Y N 214 
HIS   CG  CD2  doub Y N 215 
HIS   ND1 CE1  doub Y N 216 
HIS   ND1 HD1  sing N N 217 
HIS   CD2 NE2  sing Y N 218 
HIS   CD2 HD2  sing N N 219 
HIS   CE1 NE2  sing Y N 220 
HIS   CE1 HE1  sing N N 221 
HIS   NE2 HE2  sing N N 222 
HIS   OXT HXT  sing N N 223 
HOH   O   H1   sing N N 224 
HOH   O   H2   sing N N 225 
ILE   N   CA   sing N N 226 
ILE   N   H    sing N N 227 
ILE   N   H2   sing N N 228 
ILE   CA  C    sing N N 229 
ILE   CA  CB   sing N N 230 
ILE   CA  HA   sing N N 231 
ILE   C   O    doub N N 232 
ILE   C   OXT  sing N N 233 
ILE   CB  CG1  sing N N 234 
ILE   CB  CG2  sing N N 235 
ILE   CB  HB   sing N N 236 
ILE   CG1 CD1  sing N N 237 
ILE   CG1 HG12 sing N N 238 
ILE   CG1 HG13 sing N N 239 
ILE   CG2 HG21 sing N N 240 
ILE   CG2 HG22 sing N N 241 
ILE   CG2 HG23 sing N N 242 
ILE   CD1 HD11 sing N N 243 
ILE   CD1 HD12 sing N N 244 
ILE   CD1 HD13 sing N N 245 
ILE   OXT HXT  sing N N 246 
LEU   N   CA   sing N N 247 
LEU   N   H    sing N N 248 
LEU   N   H2   sing N N 249 
LEU   CA  C    sing N N 250 
LEU   CA  CB   sing N N 251 
LEU   CA  HA   sing N N 252 
LEU   C   O    doub N N 253 
LEU   C   OXT  sing N N 254 
LEU   CB  CG   sing N N 255 
LEU   CB  HB2  sing N N 256 
LEU   CB  HB3  sing N N 257 
LEU   CG  CD1  sing N N 258 
LEU   CG  CD2  sing N N 259 
LEU   CG  HG   sing N N 260 
LEU   CD1 HD11 sing N N 261 
LEU   CD1 HD12 sing N N 262 
LEU   CD1 HD13 sing N N 263 
LEU   CD2 HD21 sing N N 264 
LEU   CD2 HD22 sing N N 265 
LEU   CD2 HD23 sing N N 266 
LEU   OXT HXT  sing N N 267 
LYS   N   CA   sing N N 268 
LYS   N   H    sing N N 269 
LYS   N   H2   sing N N 270 
LYS   CA  C    sing N N 271 
LYS   CA  CB   sing N N 272 
LYS   CA  HA   sing N N 273 
LYS   C   O    doub N N 274 
LYS   C   OXT  sing N N 275 
LYS   CB  CG   sing N N 276 
LYS   CB  HB2  sing N N 277 
LYS   CB  HB3  sing N N 278 
LYS   CG  CD   sing N N 279 
LYS   CG  HG2  sing N N 280 
LYS   CG  HG3  sing N N 281 
LYS   CD  CE   sing N N 282 
LYS   CD  HD2  sing N N 283 
LYS   CD  HD3  sing N N 284 
LYS   CE  NZ   sing N N 285 
LYS   CE  HE2  sing N N 286 
LYS   CE  HE3  sing N N 287 
LYS   NZ  HZ1  sing N N 288 
LYS   NZ  HZ2  sing N N 289 
LYS   NZ  HZ3  sing N N 290 
LYS   OXT HXT  sing N N 291 
MET   N   CA   sing N N 292 
MET   N   H    sing N N 293 
MET   N   H2   sing N N 294 
MET   CA  C    sing N N 295 
MET   CA  CB   sing N N 296 
MET   CA  HA   sing N N 297 
MET   C   O    doub N N 298 
MET   C   OXT  sing N N 299 
MET   CB  CG   sing N N 300 
MET   CB  HB2  sing N N 301 
MET   CB  HB3  sing N N 302 
MET   CG  SD   sing N N 303 
MET   CG  HG2  sing N N 304 
MET   CG  HG3  sing N N 305 
MET   SD  CE   sing N N 306 
MET   CE  HE1  sing N N 307 
MET   CE  HE2  sing N N 308 
MET   CE  HE3  sing N N 309 
MET   OXT HXT  sing N N 310 
PGO   C1  C2   sing N N 311 
PGO   C1  O1   sing N N 312 
PGO   C1  H11  sing N N 313 
PGO   C1  H12  sing N N 314 
PGO   C2  C3   sing N N 315 
PGO   C2  O2   sing N N 316 
PGO   C2  H2   sing N N 317 
PGO   C3  H31  sing N N 318 
PGO   C3  H32  sing N N 319 
PGO   C3  H33  sing N N 320 
PGO   O1  HO1  sing N N 321 
PGO   O2  HO2  sing N N 322 
PHE   N   CA   sing N N 323 
PHE   N   H    sing N N 324 
PHE   N   H2   sing N N 325 
PHE   CA  C    sing N N 326 
PHE   CA  CB   sing N N 327 
PHE   CA  HA   sing N N 328 
PHE   C   O    doub N N 329 
PHE   C   OXT  sing N N 330 
PHE   CB  CG   sing N N 331 
PHE   CB  HB2  sing N N 332 
PHE   CB  HB3  sing N N 333 
PHE   CG  CD1  doub Y N 334 
PHE   CG  CD2  sing Y N 335 
PHE   CD1 CE1  sing Y N 336 
PHE   CD1 HD1  sing N N 337 
PHE   CD2 CE2  doub Y N 338 
PHE   CD2 HD2  sing N N 339 
PHE   CE1 CZ   doub Y N 340 
PHE   CE1 HE1  sing N N 341 
PHE   CE2 CZ   sing Y N 342 
PHE   CE2 HE2  sing N N 343 
PHE   CZ  HZ   sing N N 344 
PHE   OXT HXT  sing N N 345 
PRO   N   CA   sing N N 346 
PRO   N   CD   sing N N 347 
PRO   N   H    sing N N 348 
PRO   CA  C    sing N N 349 
PRO   CA  CB   sing N N 350 
PRO   CA  HA   sing N N 351 
PRO   C   O    doub N N 352 
PRO   C   OXT  sing N N 353 
PRO   CB  CG   sing N N 354 
PRO   CB  HB2  sing N N 355 
PRO   CB  HB3  sing N N 356 
PRO   CG  CD   sing N N 357 
PRO   CG  HG2  sing N N 358 
PRO   CG  HG3  sing N N 359 
PRO   CD  HD2  sing N N 360 
PRO   CD  HD3  sing N N 361 
PRO   OXT HXT  sing N N 362 
SER   N   CA   sing N N 363 
SER   N   H    sing N N 364 
SER   N   H2   sing N N 365 
SER   CA  C    sing N N 366 
SER   CA  CB   sing N N 367 
SER   CA  HA   sing N N 368 
SER   C   O    doub N N 369 
SER   C   OXT  sing N N 370 
SER   CB  OG   sing N N 371 
SER   CB  HB2  sing N N 372 
SER   CB  HB3  sing N N 373 
SER   OG  HG   sing N N 374 
SER   OXT HXT  sing N N 375 
THR   N   CA   sing N N 376 
THR   N   H    sing N N 377 
THR   N   H2   sing N N 378 
THR   CA  C    sing N N 379 
THR   CA  CB   sing N N 380 
THR   CA  HA   sing N N 381 
THR   C   O    doub N N 382 
THR   C   OXT  sing N N 383 
THR   CB  OG1  sing N N 384 
THR   CB  CG2  sing N N 385 
THR   CB  HB   sing N N 386 
THR   OG1 HG1  sing N N 387 
THR   CG2 HG21 sing N N 388 
THR   CG2 HG22 sing N N 389 
THR   CG2 HG23 sing N N 390 
THR   OXT HXT  sing N N 391 
TYR   N   CA   sing N N 392 
TYR   N   H    sing N N 393 
TYR   N   H2   sing N N 394 
TYR   CA  C    sing N N 395 
TYR   CA  CB   sing N N 396 
TYR   CA  HA   sing N N 397 
TYR   C   O    doub N N 398 
TYR   C   OXT  sing N N 399 
TYR   CB  CG   sing N N 400 
TYR   CB  HB2  sing N N 401 
TYR   CB  HB3  sing N N 402 
TYR   CG  CD1  doub Y N 403 
TYR   CG  CD2  sing Y N 404 
TYR   CD1 CE1  sing Y N 405 
TYR   CD1 HD1  sing N N 406 
TYR   CD2 CE2  doub Y N 407 
TYR   CD2 HD2  sing N N 408 
TYR   CE1 CZ   doub Y N 409 
TYR   CE1 HE1  sing N N 410 
TYR   CE2 CZ   sing Y N 411 
TYR   CE2 HE2  sing N N 412 
TYR   CZ  OH   sing N N 413 
TYR   OH  HH   sing N N 414 
TYR   OXT HXT  sing N N 415 
VAL   N   CA   sing N N 416 
VAL   N   H    sing N N 417 
VAL   N   H2   sing N N 418 
VAL   CA  C    sing N N 419 
VAL   CA  CB   sing N N 420 
VAL   CA  HA   sing N N 421 
VAL   C   O    doub N N 422 
VAL   C   OXT  sing N N 423 
VAL   CB  CG1  sing N N 424 
VAL   CB  CG2  sing N N 425 
VAL   CB  HB   sing N N 426 
VAL   CG1 HG11 sing N N 427 
VAL   CG1 HG12 sing N N 428 
VAL   CG1 HG13 sing N N 429 
VAL   CG2 HG21 sing N N 430 
VAL   CG2 HG22 sing N N 431 
VAL   CG2 HG23 sing N N 432 
VAL   OXT HXT  sing N N 433 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121054 1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121052 2 
'Japan Society for the Promotion of Science (JSPS)'        Japan 15H02896      3 
'Japan Society for the Promotion of Science (JSPS)'        Japan 16K13044      4 
'Japan Society for the Promotion of Science (JSPS)'        Japan 18H03190      5 
'Japan Society for the Promotion of Science (JSPS)'        Japan 21H03354      6 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6KXY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YTL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022029 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016302 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009910 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP   A 1 6   ? -7.65326  -5.80903  -1.05561  1.000 62.35564 ? 202 ASP   A N   1 
ATOM   2    C CA  . ASP   A 1 6   ? -9.04065  -6.21857  -1.23600  1.000 64.06338 ? 202 ASP   A CA  1 
ATOM   3    C C   . ASP   A 1 6   ? -9.17553  -7.16767  -2.42013  1.000 61.29153 ? 202 ASP   A C   1 
ATOM   4    O O   . ASP   A 1 6   ? -8.84327  -6.81545  -3.55196  1.000 59.65275 ? 202 ASP   A O   1 
ATOM   5    C CB  . ASP   A 1 6   ? -9.94191  -4.99826  -1.43386  1.000 62.99007 ? 202 ASP   A CB  1 
ATOM   6    C CG  . ASP   A 1 6   ? -11.39388 -5.37668  -1.65187  1.000 65.41969 ? 202 ASP   A CG  1 
ATOM   7    O OD1 . ASP   A 1 6   ? -11.88196 -6.29080  -0.95430  1.000 66.32115 ? 202 ASP   A OD1 1 
ATOM   8    O OD2 . ASP   A 1 6   ? -12.04685 -4.76130  -2.52078  1.000 64.61777 ? 202 ASP   A OD2 1 
ATOM   9    N N   . LEU   A 1 7   ? -9.67025  -8.37444  -2.15297  1.000 60.42343 ? 203 LEU   A N   1 
ATOM   10   C CA  . LEU   A 1 7   ? -9.80891  -9.39163  -3.18497  1.000 53.96426 ? 203 LEU   A CA  1 
ATOM   11   C C   . LEU   A 1 7   ? -11.11632 -9.28361  -3.95945  1.000 56.47396 ? 203 LEU   A C   1 
ATOM   12   O O   . LEU   A 1 7   ? -11.26519 -9.95420  -4.98684  1.000 50.70745 ? 203 LEU   A O   1 
ATOM   13   C CB  . LEU   A 1 7   ? -9.69388  -10.78857 -2.56441  1.000 55.01375 ? 203 LEU   A CB  1 
ATOM   14   C CG  . LEU   A 1 7   ? -8.77860  -11.76518 -3.30485  1.000 53.23462 ? 203 LEU   A CG  1 
ATOM   15   C CD1 . LEU   A 1 7   ? -7.34549  -11.26224 -3.27329  1.000 51.32388 ? 203 LEU   A CD1 1 
ATOM   16   C CD2 . LEU   A 1 7   ? -8.86746  -13.15642 -2.70580  1.000 42.59625 ? 203 LEU   A CD2 1 
ATOM   17   N N   . LYS   A 1 8   ? -12.06169 -8.46012  -3.49839  1.000 56.56027 ? 204 LYS   A N   1 
ATOM   18   C CA  . LYS   A 1 8   ? -13.31730 -8.29879  -4.22415  1.000 57.71291 ? 204 LYS   A CA  1 
ATOM   19   C C   . LYS   A 1 8   ? -13.12589 -7.50656  -5.51108  1.000 54.11594 ? 204 LYS   A C   1 
ATOM   20   O O   . LYS   A 1 8   ? -13.82931 -7.75045  -6.49819  1.000 52.08521 ? 204 LYS   A O   1 
ATOM   21   C CB  . LYS   A 1 8   ? -14.35758 -7.61878  -3.33333  1.000 56.46644 ? 204 LYS   A CB  1 
ATOM   22   C CG  . LYS   A 1 8   ? -15.15030 -8.57751  -2.45869  1.000 56.40232 ? 204 LYS   A CG  1 
ATOM   23   C CD  . LYS   A 1 8   ? -16.59415 -8.12338  -2.30381  1.000 56.21177 ? 204 LYS   A CD  1 
ATOM   24   C CE  . LYS   A 1 8   ? -16.71998 -7.01009  -1.27442  1.000 58.81146 ? 204 LYS   A CE  1 
ATOM   25   N NZ  . LYS   A 1 8   ? -15.97849 -7.32013  -0.02008  1.000 58.47918 ? 204 LYS   A NZ  1 
ATOM   26   N N   . SER   A 1 9   ? -12.18550 -6.56161  -5.52287  1.000 53.17423 ? 205 SER   A N   1 
ATOM   27   C CA  . SER   A 1 9   ? -11.90565 -5.74313  -6.69551  1.000 55.83336 ? 205 SER   A CA  1 
ATOM   28   C C   . SER   A 1 9   ? -10.55401 -6.07196  -7.32124  1.000 52.17503 ? 205 SER   A C   1 
ATOM   29   O O   . SER   A 1 9   ? -9.98545  -5.23895  -8.03445  1.000 52.11695 ? 205 SER   A O   1 
ATOM   30   C CB  . SER   A 1 9   ? -11.97417 -4.25991  -6.33017  1.000 47.84998 ? 205 SER   A CB  1 
ATOM   31   O OG  . SER   A 1 9   ? -11.03134 -3.94165  -5.32105  1.000 53.81736 ? 205 SER   A OG  1 
ATOM   32   N N   . LEU   A 1 10  ? -10.02913 -7.27402  -7.07181  1.000 49.31384 ? 206 LEU   A N   1 
ATOM   33   C CA  . LEU   A 1 10  ? -8.70672  -7.61984  -7.58315  1.000 44.17503 ? 206 LEU   A CA  1 
ATOM   34   C C   . LEU   A 1 10  ? -8.72063  -7.79546  -9.09697  1.000 37.72425 ? 206 LEU   A C   1 
ATOM   35   O O   . LEU   A 1 10  ? -7.82352  -7.30227  -9.79058  1.000 43.00317 ? 206 LEU   A O   1 
ATOM   36   C CB  . LEU   A 1 10  ? -8.19338  -8.88734  -6.90035  1.000 45.27357 ? 206 LEU   A CB  1 
ATOM   37   C CG  . LEU   A 1 10  ? -6.74334  -9.25873  -7.21929  1.000 43.74456 ? 206 LEU   A CG  1 
ATOM   38   C CD1 . LEU   A 1 10  ? -5.78153  -8.24151  -6.62227  1.000 43.36651 ? 206 LEU   A CD1 1 
ATOM   39   C CD2 . LEU   A 1 10  ? -6.41519  -10.66157 -6.73281  1.000 40.22043 ? 206 LEU   A CD2 1 
ATOM   40   N N   . ALA   A 1 11  ? -9.72730  -8.49477  -9.62813  1.000 36.32526 ? 207 ALA   A N   1 
ATOM   41   C CA  . ALA   A 1 11  ? -9.78122  -8.73274  -11.06751 1.000 39.33157 ? 207 ALA   A CA  1 
ATOM   42   C C   . ALA   A 1 11  ? -9.95354  -7.43159  -11.84054 1.000 45.56959 ? 207 ALA   A C   1 
ATOM   43   O O   . ALA   A 1 11  ? -9.36507  -7.25872  -12.91450 1.000 33.55191 ? 207 ALA   A O   1 
ATOM   44   C CB  . ALA   A 1 11  ? -10.91192 -9.70473  -11.39913 1.000 34.22820 ? 207 ALA   A CB  1 
ATOM   45   N N   . LYS   A 1 12  ? -10.75769 -6.50675  -11.31167 1.000 44.37926 ? 208 LYS   A N   1 
ATOM   46   C CA  . LYS   A 1 12  ? -10.96480 -5.22961  -11.98590 1.000 44.75171 ? 208 LYS   A CA  1 
ATOM   47   C C   . LYS   A 1 12  ? -9.69832  -4.38345  -11.96354 1.000 39.10082 ? 208 LYS   A C   1 
ATOM   48   O O   . LYS   A 1 12  ? -9.36715  -3.72492  -12.95661 1.000 41.04996 ? 208 LYS   A O   1 
ATOM   49   C CB  . LYS   A 1 12  ? -12.12882 -4.48293  -11.33234 1.000 51.91057 ? 208 LYS   A CB  1 
ATOM   50   C CG  . LYS   A 1 12  ? -12.85578 -3.50423  -12.24274 1.000 49.61810 ? 208 LYS   A CG  1 
ATOM   51   C CD  . LYS   A 1 12  ? -13.25770 -2.24582  -11.48602 1.000 55.66881 ? 208 LYS   A CD  1 
ATOM   52   C CE  . LYS   A 1 12  ? -13.89826 -1.22062  -12.40882 1.000 51.34794 ? 208 LYS   A CE  1 
ATOM   53   N NZ  . LYS   A 1 12  ? -14.00722 0.11761   -11.76557 1.000 57.79446 ? 208 LYS   A NZ  1 
ATOM   54   N N   . ARG   A 1 13  ? -8.97317  -4.39706  -10.84213 1.000 40.83423 ? 209 ARG   A N   1 
ATOM   55   C CA  . ARG   A 1 13  ? -7.76763  -3.58278  -10.72477 1.000 35.49215 ? 209 ARG   A CA  1 
ATOM   56   C C   . ARG   A 1 13  ? -6.64667  -4.11419  -11.61037 1.000 40.39851 ? 209 ARG   A C   1 
ATOM   57   O O   . ARG   A 1 13  ? -5.90242  -3.33203  -12.21451 1.000 31.63620 ? 209 ARG   A O   1 
ATOM   58   C CB  . ARG   A 1 13  ? -7.31573  -3.52460  -9.26511  1.000 41.64982 ? 209 ARG   A CB  1 
ATOM   59   C CG  . ARG   A 1 13  ? -8.04098  -2.47945  -8.42833  1.000 51.30036 ? 209 ARG   A CG  1 
ATOM   60   C CD  . ARG   A 1 13  ? -7.47161  -2.40286  -7.01838  1.000 53.55447 ? 209 ARG   A CD  1 
ATOM   61   N NE  . ARG   A 1 13  ? -7.59086  -3.67305  -6.31195  1.000 60.92948 ? 209 ARG   A NE  1 
ATOM   62   C CZ  . ARG   A 1 13  ? -7.16345  -3.88754  -5.07493  1.000 61.86694 ? 209 ARG   A CZ  1 
ATOM   63   N NH1 . ARG   A 1 13  ? -7.30468  -5.06578  -4.48932  1.000 56.78746 ? 209 ARG   A NH1 1 
ATOM   64   N NH2 . ARG   A 1 13  ? -6.57793  -2.89585  -4.40928  1.000 60.17043 ? 209 ARG   A NH2 1 
ATOM   65   N N   . ILE   A 1 14  ? -6.50464  -5.43861  -11.69692 1.000 32.82225 ? 210 ILE   A N   1 
ATOM   66   C CA  . ILE   A 1 14  ? -5.45678  -6.01133  -12.53663 1.000 32.28709 ? 210 ILE   A CA  1 
ATOM   67   C C   . ILE   A 1 14  ? -5.77078  -5.78524  -14.01101 1.000 31.27720 ? 210 ILE   A C   1 
ATOM   68   O O   . ILE   A 1 14  ? -4.88283  -5.44645  -14.80379 1.000 29.96663 ? 210 ILE   A O   1 
ATOM   69   C CB  . ILE   A 1 14  ? -5.26610  -7.50398  -12.20979 1.000 27.28796 ? 210 ILE   A CB  1 
ATOM   70   C CG1 . ILE   A 1 14  ? -4.30425  -7.66602  -11.03176 1.000 28.03351 ? 210 ILE   A CG1 1 
ATOM   71   C CG2 . ILE   A 1 14  ? -4.73776  -8.26022  -13.41698 1.000 26.75791 ? 210 ILE   A CG2 1 
ATOM   72   C CD1 . ILE   A 1 14  ? -4.61633  -8.84829  -10.14747 1.000 36.65442 ? 210 ILE   A CD1 1 
ATOM   73   N N   . TYR   A 1 15  ? -7.03685  -5.95777  -14.40049 1.000 28.99265 ? 211 TYR   A N   1 
ATOM   74   C CA  . TYR   A 1 15  ? -7.43476  -5.67963  -15.77741 1.000 35.85980 ? 211 TYR   A CA  1 
ATOM   75   C C   . TYR   A 1 15  ? -7.17603  -4.22001  -16.14008 1.000 32.90597 ? 211 TYR   A C   1 
ATOM   76   O O   . TYR   A 1 15  ? -6.71264  -3.91984  -17.24673 1.000 31.14932 ? 211 TYR   A O   1 
ATOM   77   C CB  . TYR   A 1 15  ? -8.91044  -6.03060  -15.97065 1.000 33.09099 ? 211 TYR   A CB  1 
ATOM   78   C CG  . TYR   A 1 15  ? -9.42485  -5.87758  -17.38669 1.000 38.02640 ? 211 TYR   A CG  1 
ATOM   79   C CD1 . TYR   A 1 15  ? -10.77655 -5.67834  -17.62693 1.000 40.21536 ? 211 TYR   A CD1 1 
ATOM   80   C CD2 . TYR   A 1 15  ? -8.57343  -5.97277  -18.48176 1.000 33.75971 ? 211 TYR   A CD2 1 
ATOM   81   C CE1 . TYR   A 1 15  ? -11.26310 -5.54227  -18.91018 1.000 46.63878 ? 211 TYR   A CE1 1 
ATOM   82   C CE2 . TYR   A 1 15  ? -9.05299  -5.83885  -19.77419 1.000 40.12389 ? 211 TYR   A CE2 1 
ATOM   83   C CZ  . TYR   A 1 15  ? -10.39877 -5.62459  -19.98075 1.000 40.53479 ? 211 TYR   A CZ  1 
ATOM   84   O OH  . TYR   A 1 15  ? -10.89202 -5.49322  -21.25855 1.000 39.59147 ? 211 TYR   A OH  1 
ATOM   85   N N   . GLU   A 1 16  ? -7.46101  -3.29790  -15.21711 1.000 35.28173 ? 212 GLU   A N   1 
ATOM   86   C CA  . GLU   A 1 16  ? -7.21829  -1.88452  -15.48993 1.000 34.00147 ? 212 GLU   A CA  1 
ATOM   87   C C   . GLU   A 1 16  ? -5.72874  -1.58918  -15.61320 1.000 34.50224 ? 212 GLU   A C   1 
ATOM   88   O O   . GLU   A 1 16  ? -5.31318  -0.83524  -16.50050 1.000 30.77831 ? 212 GLU   A O   1 
ATOM   89   C CB  . GLU   A 1 16  ? -7.84904  -1.02168  -14.39888 1.000 35.13173 ? 212 GLU   A CB  1 
ATOM   90   C CG  . GLU   A 1 16  ? -9.13374  -0.33637  -14.82698 1.000 48.11976 ? 212 GLU   A CG  1 
ATOM   91   C CD  . GLU   A 1 16  ? -10.10570 -0.15401  -13.68181 1.000 53.09568 ? 212 GLU   A CD  1 
ATOM   92   O OE1 . GLU   A 1 16  ? -9.64874  0.04646   -12.53653 1.000 42.94360 ? 212 GLU   A OE1 1 
ATOM   93   O OE2 . GLU   A 1 16  ? -11.32761 -0.21197  -13.92907 1.000 55.81777 ? 212 GLU   A OE2 1 
ATOM   94   N N   . ALA   A 1 17  ? -4.91083  -2.16619  -14.72846 1.000 29.08567 ? 213 ALA   A N   1 
ATOM   95   C CA  . ALA   A 1 17  ? -3.46573  -1.99290  -14.83736 1.000 35.15611 ? 213 ALA   A CA  1 
ATOM   96   C C   . ALA   A 1 17  ? -2.93139  -2.58424  -16.13348 1.000 30.92919 ? 213 ALA   A C   1 
ATOM   97   O O   . ALA   A 1 17  ? -1.94523  -2.08353  -16.68744 1.000 31.14285 ? 213 ALA   A O   1 
ATOM   98   C CB  . ALA   A 1 17  ? -2.76830  -2.63067  -13.63745 1.000 30.35488 ? 213 ALA   A CB  1 
ATOM   99   N N   . TYR   A 1 18  ? -3.56701  -3.64875  -16.62490 1.000 29.39967 ? 214 TYR   A N   1 
ATOM   100  C CA  . TYR   A 1 18  ? -3.18920  -4.23221  -17.90685 1.000 31.98842 ? 214 TYR   A CA  1 
ATOM   101  C C   . TYR   A 1 18  ? -3.46614  -3.26230  -19.04996 1.000 36.96576 ? 214 TYR   A C   1 
ATOM   102  O O   . TYR   A 1 18  ? -2.60105  -3.02479  -19.90112 1.000 31.66074 ? 214 TYR   A O   1 
ATOM   103  C CB  . TYR   A 1 18  ? -3.94588  -5.54685  -18.10115 1.000 25.22292 ? 214 TYR   A CB  1 
ATOM   104  C CG  . TYR   A 1 18  ? -3.65242  -6.30052  -19.37969 1.000 30.53200 ? 214 TYR   A CG  1 
ATOM   105  C CD1 . TYR   A 1 18  ? -2.71833  -7.32877  -19.40173 1.000 33.65621 ? 214 TYR   A CD1 1 
ATOM   106  C CD2 . TYR   A 1 18  ? -4.33831  -6.01376  -20.55382 1.000 32.70591 ? 214 TYR   A CD2 1 
ATOM   107  C CE1 . TYR   A 1 18  ? -2.45787  -8.03261  -20.56126 1.000 29.72957 ? 214 TYR   A CE1 1 
ATOM   108  C CE2 . TYR   A 1 18  ? -4.08310  -6.71144  -21.71878 1.000 35.59053 ? 214 TYR   A CE2 1 
ATOM   109  C CZ  . TYR   A 1 18  ? -3.14325  -7.72005  -21.71624 1.000 36.10300 ? 214 TYR   A CZ  1 
ATOM   110  O OH  . TYR   A 1 18  ? -2.88592  -8.41911  -22.87331 1.000 47.85528 ? 214 TYR   A OH  1 
ATOM   111  N N   . LEU   A 1 19  ? -4.67101  -2.68597  -19.08073 1.000 31.81749 ? 215 LEU   A N   1 
ATOM   112  C CA  . LEU   A 1 19  ? -5.01615  -1.73912  -20.13651 1.000 30.66423 ? 215 LEU   A CA  1 
ATOM   113  C C   . LEU   A 1 19  ? -4.22581  -0.44359  -20.01450 1.000 34.78131 ? 215 LEU   A C   1 
ATOM   114  O O   . LEU   A 1 19  ? -3.99784  0.23877   -21.01954 1.000 39.85804 ? 215 LEU   A O   1 
ATOM   115  C CB  . LEU   A 1 19  ? -6.51579  -1.44126  -20.10682 1.000 34.79829 ? 215 LEU   A CB  1 
ATOM   116  C CG  . LEU   A 1 19  ? -7.46522  -2.63270  -20.24078 1.000 34.73766 ? 215 LEU   A CG  1 
ATOM   117  C CD1 . LEU   A 1 19  ? -8.88387  -2.23266  -19.85915 1.000 41.61606 ? 215 LEU   A CD1 1 
ATOM   118  C CD2 . LEU   A 1 19  ? -7.42371  -3.19862  -21.65134 1.000 36.58429 ? 215 LEU   A CD2 1 
ATOM   119  N N   . LYS   A 1 20  ? -3.79970  -0.09090  -18.80120 1.000 30.48358 ? 216 LYS   A N   1 
ATOM   120  C CA  . LYS   A 1 20  ? -3.09291  1.16633   -18.59020 1.000 36.86492 ? 216 LYS   A CA  1 
ATOM   121  C C   . LYS   A 1 20  ? -1.63275  1.09373   -19.01764 1.000 41.73300 ? 216 LYS   A C   1 
ATOM   122  O O   . LYS   A 1 20  ? -1.08241  2.09391   -19.49254 1.000 35.75264 ? 216 LYS   A O   1 
ATOM   123  C CB  . LYS   A 1 20  ? -3.17089  1.56998   -17.11663 1.000 35.03122 ? 216 LYS   A CB  1 
ATOM   124  C CG  . LYS   A 1 20  ? -4.39280  2.39203   -16.74750 1.000 44.80957 ? 216 LYS   A CG  1 
ATOM   125  C CD  . LYS   A 1 20  ? -4.25399  2.97083   -15.34730 1.000 48.89307 ? 216 LYS   A CD  1 
ATOM   126  C CE  . LYS   A 1 20  ? -5.20334  2.29600   -14.37047 1.000 45.66668 ? 216 LYS   A CE  1 
ATOM   127  N NZ  . LYS   A 1 20  ? -6.47007  3.06153   -14.20711 1.000 50.23159 ? 216 LYS   A NZ  1 
ATOM   128  N N   . ASN   A 1 21  ? -0.99221  -0.06639  -18.86422 1.000 33.94390 ? 217 ASN   A N   1 
ATOM   129  C CA  . ASN   A 1 21  ? 0.45769   -0.15295  -18.97806 1.000 34.48287 ? 217 ASN   A CA  1 
ATOM   130  C C   . ASN   A 1 21  ? 0.95210   -0.78162  -20.27367 1.000 31.13321 ? 217 ASN   A C   1 
ATOM   131  O O   . ASN   A 1 21  ? 2.11096   -0.56038  -20.63910 1.000 36.10482 ? 217 ASN   A O   1 
ATOM   132  C CB  . ASN   A 1 21  ? 1.03122   -0.94111  -17.79400 1.000 32.98958 ? 217 ASN   A CB  1 
ATOM   133  C CG  . ASN   A 1 21  ? 0.99508   -0.15322  -16.50140 1.000 33.08426 ? 217 ASN   A CG  1 
ATOM   134  O OD1 . ASN   A 1 21  ? 1.76634   0.78773   -16.31536 1.000 34.79090 ? 217 ASN   A OD1 1 
ATOM   135  N ND2 . ASN   A 1 21  ? 0.09215   -0.52774  -15.60294 1.000 32.05290 ? 217 ASN   A ND2 1 
ATOM   136  N N   . PHE   A 1 22  ? 0.12675   -1.55171  -20.97461 1.000 33.30398 ? 218 PHE   A N   1 
ATOM   137  C CA  . PHE   A 1 22  ? 0.56258   -2.26221  -22.17091 1.000 34.43612 ? 218 PHE   A CA  1 
ATOM   138  C C   . PHE   A 1 22  ? 0.04067   -1.54942  -23.41183 1.000 37.17837 ? 218 PHE   A C   1 
ATOM   139  O O   . PHE   A 1 22  ? -1.17454  -1.43312  -23.60186 1.000 34.29576 ? 218 PHE   A O   1 
ATOM   140  C CB  . PHE   A 1 22  ? 0.09385   -3.71603  -22.13833 1.000 36.92487 ? 218 PHE   A CB  1 
ATOM   141  C CG  . PHE   A 1 22  ? 0.71812   -4.52016  -21.03735 1.000 32.29175 ? 218 PHE   A CG  1 
ATOM   142  C CD1 . PHE   A 1 22  ? 2.09557   -4.63094  -20.94131 1.000 33.04858 ? 218 PHE   A CD1 1 
ATOM   143  C CD2 . PHE   A 1 22  ? -0.06812  -5.14967  -20.08865 1.000 29.73144 ? 218 PHE   A CD2 1 
ATOM   144  C CE1 . PHE   A 1 22  ? 2.67743   -5.36368  -19.92462 1.000 31.99336 ? 218 PHE   A CE1 1 
ATOM   145  C CE2 . PHE   A 1 22  ? 0.50697   -5.88406  -19.06995 1.000 32.96853 ? 218 PHE   A CE2 1 
ATOM   146  C CZ  . PHE   A 1 22  ? 1.88144   -5.99134  -18.98735 1.000 30.71253 ? 218 PHE   A CZ  1 
ATOM   147  N N   . ASN   A 1 23  ? 0.96518   -1.08174  -24.25600 1.000 38.99353 ? 219 ASN   A N   1 
ATOM   148  C CA  . ASN   A 1 23  ? 0.57686   -0.37275  -25.47034 1.000 43.05442 ? 219 ASN   A CA  1 
ATOM   149  C C   . ASN   A 1 23  ? -0.16525  -1.27938  -26.44428 1.000 40.65574 ? 219 ASN   A C   1 
ATOM   150  O O   . ASN   A 1 23  ? -0.96249  -0.79474  -27.25476 1.000 39.48362 ? 219 ASN   A O   1 
ATOM   151  C CB  . ASN   A 1 23  ? 1.81461   0.24383   -26.13130 1.000 42.19492 ? 219 ASN   A CB  1 
ATOM   152  C CG  . ASN   A 1 23  ? 2.79160   -0.80192  -26.66155 1.000 53.87256 ? 219 ASN   A CG  1 
ATOM   153  O OD1 . ASN   A 1 23  ? 2.47065   -1.57961  -27.56188 1.000 52.76855 ? 219 ASN   A OD1 1 
ATOM   154  N ND2 . ASN   A 1 23  ? 3.99468   -0.82203  -26.09627 1.000 50.17206 ? 219 ASN   A ND2 1 
ATOM   155  N N   . MET   A 1 24  ? 0.07653   -2.58544  -26.38194 1.000 41.29128 ? 220 MET   A N   1 
ATOM   156  C CA  . MET   A 1 24  ? -0.55056  -3.54801  -27.27607 1.000 44.31721 ? 220 MET   A CA  1 
ATOM   157  C C   . MET   A 1 24  ? -1.27405  -4.60539  -26.45616 1.000 40.56442 ? 220 MET   A C   1 
ATOM   158  O O   . MET   A 1 24  ? -0.70218  -5.16614  -25.51530 1.000 42.10017 ? 220 MET   A O   1 
ATOM   159  C CB  . MET   A 1 24  ? 0.48822   -4.20214  -28.19193 1.000 37.16807 ? 220 MET   A CB  1 
ATOM   160  C CG  . MET   A 1 24  ? -0.09321  -5.19196  -29.18718 1.000 39.03238 ? 220 MET   A CG  1 
ATOM   161  S SD  . MET   A 1 24  ? -1.23275  -4.42956  -30.35808 1.000 45.46399 ? 220 MET   A SD  1 
ATOM   162  C CE  . MET   A 1 24  ? -0.11953  -3.34865  -31.25386 1.000 43.29434 ? 220 MET   A CE  1 
ATOM   163  N N   . ASN   A 1 25  ? -2.53159  -4.86742  -26.80998 1.000 39.60274 ? 221 ASN   A N   1 
ATOM   164  C CA  . ASN   A 1 25  ? -3.30020  -5.92922  -26.17283 1.000 44.98333 ? 221 ASN   A CA  1 
ATOM   165  C C   . ASN   A 1 25  ? -3.99778  -6.77392  -27.23220 1.000 45.20123 ? 221 ASN   A C   1 
ATOM   166  O O   . ASN   A 1 25  ? -3.75360  -6.59736  -28.43037 1.000 44.35346 ? 221 ASN   A O   1 
ATOM   167  C CB  . ASN   A 1 25  ? -4.31022  -5.34813  -25.17899 1.000 43.33551 ? 221 ASN   A CB  1 
ATOM   168  C CG  . ASN   A 1 25  ? -5.16803  -4.25432  -25.78490 1.000 48.97761 ? 221 ASN   A CG  1 
ATOM   169  O OD1 . ASN   A 1 25  ? -5.78585  -4.44053  -26.83253 1.000 54.01229 ? 221 ASN   A OD1 1 
ATOM   170  N ND2 . ASN   A 1 25  ? -5.21093  -3.10271  -25.12344 1.000 46.62566 ? 221 ASN   A ND2 1 
ATOM   171  N N   . LYS   A 1 26  ? -4.87207  -7.68722  -26.80447 1.000 40.75668 ? 222 LYS   A N   1 
ATOM   172  C CA  . LYS   A 1 26  ? -5.47591  -8.62884  -27.74343 1.000 39.77211 ? 222 LYS   A CA  1 
ATOM   173  C C   . LYS   A 1 26  ? -6.53199  -7.95470  -28.61177 1.000 39.77283 ? 222 LYS   A C   1 
ATOM   174  O O   . LYS   A 1 26  ? -6.57937  -8.17392  -29.82789 1.000 37.45113 ? 222 LYS   A O   1 
ATOM   175  C CB  . LYS   A 1 26  ? -6.07897  -9.81370  -26.98881 1.000 32.14484 ? 222 LYS   A CB  1 
ATOM   176  C CG  . LYS   A 1 26  ? -6.51087  -10.96006 -27.89185 1.000 31.16872 ? 222 LYS   A CG  1 
ATOM   177  C CD  . LYS   A 1 26  ? -6.54373  -12.27939 -27.13777 1.000 30.47987 ? 222 LYS   A CD  1 
ATOM   178  C CE  . LYS   A 1 26  ? -6.77638  -13.44814 -28.08255 1.000 37.17477 ? 222 LYS   A CE  1 
ATOM   179  N NZ  . LYS   A 1 26  ? -6.87551  -14.74651 -27.35815 1.000 34.62020 ? 222 LYS   A NZ  1 
ATOM   180  N N   . VAL   A 1 27  ? -7.39573  -7.13580  -28.00635 1.000 39.60724 ? 223 VAL   A N   1 
ATOM   181  C CA  . VAL   A 1 27  ? -8.46137  -6.50596  -28.78096 1.000 44.06523 ? 223 VAL   A CA  1 
ATOM   182  C C   . VAL   A 1 27  ? -7.89110  -5.48096  -29.75510 1.000 44.57101 ? 223 VAL   A C   1 
ATOM   183  O O   . VAL   A 1 27  ? -8.49461  -5.20546  -30.79916 1.000 45.67255 ? 223 VAL   A O   1 
ATOM   184  C CB  . VAL   A 1 27  ? -9.51593  -5.88462  -27.84357 1.000 50.73313 ? 223 VAL   A CB  1 
ATOM   185  C CG1 . VAL   A 1 27  ? -9.05258  -4.53126  -27.31590 1.000 49.70109 ? 223 VAL   A CG1 1 
ATOM   186  C CG2 . VAL   A 1 27  ? -10.85388 -5.76235  -28.55857 1.000 51.87676 ? 223 VAL   A CG2 1 
ATOM   187  N N   . LYS   A 1 28  ? -6.72257  -4.91247  -29.44863 1.000 46.86385 ? 224 LYS   A N   1 
ATOM   188  C CA  . LYS   A 1 28  ? -6.07686  -3.99827  -30.38433 1.000 47.91956 ? 224 LYS   A CA  1 
ATOM   189  C C   . LYS   A 1 28  ? -5.37001  -4.75831  -31.50057 1.000 49.13951 ? 224 LYS   A C   1 
ATOM   190  O O   . LYS   A 1 28  ? -5.42590  -4.34965  -32.66600 1.000 49.02170 ? 224 LYS   A O   1 
ATOM   191  C CB  . LYS   A 1 28  ? -5.08794  -3.09619  -29.64376 1.000 45.87166 ? 224 LYS   A CB  1 
ATOM   192  C CG  . LYS   A 1 28  ? -5.71108  -1.84218  -29.04759 1.000 55.65718 ? 224 LYS   A CG  1 
ATOM   193  C CD  . LYS   A 1 28  ? -4.79560  -1.21032  -28.00793 1.000 52.15354 ? 224 LYS   A CD  1 
ATOM   194  C CE  . LYS   A 1 28  ? -4.30272  0.15566   -28.45816 1.000 53.08775 ? 224 LYS   A CE  1 
ATOM   195  N NZ  . LYS   A 1 28  ? -2.99044  0.51256   -27.84658 1.000 39.80493 ? 224 LYS   A NZ  1 
ATOM   196  N N   . ALA   A 1 29  ? -4.70799  -5.86832  -31.16365 1.000 43.95261 ? 225 ALA   A N   1 
ATOM   197  C CA  . ALA   A 1 29  ? -4.01841  -6.65714  -32.17959 1.000 43.08268 ? 225 ALA   A CA  1 
ATOM   198  C C   . ALA   A 1 29  ? -5.00633  -7.36231  -33.09965 1.000 43.31173 ? 225 ALA   A C   1 
ATOM   199  O O   . ALA   A 1 29  ? -4.76949  -7.46748  -34.30856 1.000 42.76664 ? 225 ALA   A O   1 
ATOM   200  C CB  . ALA   A 1 29  ? -3.08763  -7.67084  -31.51619 1.000 34.45284 ? 225 ALA   A CB  1 
ATOM   201  N N   . ARG   A 1 30  ? -6.11663  -7.85745  -32.54636 1.000 43.33585 ? 226 ARG   A N   1 
ATOM   202  C CA  . ARG   A 1 30  ? -7.12086  -8.51624  -33.37501 1.000 47.39462 ? 226 ARG   A CA  1 
ATOM   203  C C   . ARG   A 1 30  ? -7.74375  -7.54788  -34.37136 1.000 48.42167 ? 226 ARG   A C   1 
ATOM   204  O O   . ARG   A 1 30  ? -8.13032  -7.95396  -35.47339 1.000 56.95206 ? 226 ARG   A O   1 
ATOM   205  C CB  . ARG   A 1 30  ? -8.20251  -9.14308  -32.49415 1.000 45.70933 ? 226 ARG   A CB  1 
ATOM   206  C CG  . ARG   A 1 30  ? -8.14656  -10.66366 -32.40673 1.000 52.89055 ? 226 ARG   A CG  1 
ATOM   207  C CD  . ARG   A 1 30  ? -6.73633  -11.17092 -32.13667 1.000 53.40333 ? 226 ARG   A CD  1 
ATOM   208  N NE  . ARG   A 1 30  ? -6.50626  -12.47994 -32.73765 1.000 56.17309 ? 226 ARG   A NE  1 
ATOM   209  C CZ  . ARG   A 1 30  ? -5.32896  -13.08923 -32.78386 1.000 56.79214 ? 226 ARG   A CZ  1 
ATOM   210  N NH1 . ARG   A 1 30  ? -4.24388  -12.53751 -32.26573 1.000 44.38857 ? 226 ARG   A NH1 1 
ATOM   211  N NH2 . ARG   A 1 30  ? -5.23838  -14.28344 -33.36287 1.000 56.41931 ? 226 ARG   A NH2 1 
ATOM   212  N N   . VAL   A 1 31  ? -7.84801  -6.26876  -34.00490 1.000 49.90978 ? 227 VAL   A N   1 
ATOM   213  C CA  . VAL   A 1 31  ? -8.37102  -5.26870  -34.92971 1.000 50.80090 ? 227 VAL   A CA  1 
ATOM   214  C C   . VAL   A 1 31  ? -7.42016  -5.08342  -36.10620 1.000 56.95957 ? 227 VAL   A C   1 
ATOM   215  O O   . VAL   A 1 31  ? -7.84938  -5.00716  -37.26420 1.000 61.32056 ? 227 VAL   A O   1 
ATOM   216  C CB  . VAL   A 1 31  ? -8.62707  -3.94366  -34.18600 1.000 57.53335 ? 227 VAL   A CB  1 
ATOM   217  C CG1 . VAL   A 1 31  ? -8.39807  -2.74808  -35.10473 1.000 52.58036 ? 227 VAL   A CG1 1 
ATOM   218  C CG2 . VAL   A 1 31  ? -10.03495 -3.92072  -33.60810 1.000 56.75240 ? 227 VAL   A CG2 1 
ATOM   219  N N   . ILE   A 1 32  ? -6.11495  -5.02247  -35.83231 1.000 52.20303 ? 228 ILE   A N   1 
ATOM   220  C CA  . ILE   A 1 32  ? -5.13866  -4.83228  -36.90025 1.000 50.33449 ? 228 ILE   A CA  1 
ATOM   221  C C   . ILE   A 1 32  ? -5.02188  -6.09068  -37.75135 1.000 53.18295 ? 228 ILE   A C   1 
ATOM   222  O O   . ILE   A 1 32  ? -4.96512  -6.01883  -38.98494 1.000 59.47242 ? 228 ILE   A O   1 
ATOM   223  C CB  . ILE   A 1 32  ? -3.77870  -4.41719  -36.31039 1.000 44.20349 ? 228 ILE   A CB  1 
ATOM   224  C CG1 . ILE   A 1 32  ? -3.90957  -3.09683  -35.54798 1.000 47.47962 ? 228 ILE   A CG1 1 
ATOM   225  C CG2 . ILE   A 1 32  ? -2.73082  -4.30300  -37.40795 1.000 41.27108 ? 228 ILE   A CG2 1 
ATOM   226  C CD1 . ILE   A 1 32  ? -2.69677  -2.75249  -34.70968 1.000 44.02299 ? 228 ILE   A CD1 1 
ATOM   227  N N   . LEU   A 1 33  ? -4.99332  -7.26227  -37.11211 1.000 52.53271 ? 229 LEU   A N   1 
ATOM   228  C CA  . LEU   A 1 33  ? -4.87437  -8.52289  -37.83553 1.000 46.84524 ? 229 LEU   A CA  1 
ATOM   229  C C   . LEU   A 1 33  ? -6.08325  -8.82202  -38.71286 1.000 56.98323 ? 229 LEU   A C   1 
ATOM   230  O O   . LEU   A 1 33  ? -6.01351  -9.73988  -39.53737 1.000 55.03880 ? 229 LEU   A O   1 
ATOM   231  C CB  . LEU   A 1 33  ? -4.65456  -9.67172  -36.84954 1.000 44.63471 ? 229 LEU   A CB  1 
ATOM   232  C CG  . LEU   A 1 33  ? -3.29105  -9.71071  -36.15664 1.000 48.69909 ? 229 LEU   A CG  1 
ATOM   233  C CD1 . LEU   A 1 33  ? -3.24435  -10.81925 -35.11734 1.000 46.20843 ? 229 LEU   A CD1 1 
ATOM   234  C CD2 . LEU   A 1 33  ? -2.18099  -9.88660  -37.17926 1.000 43.15248 ? 229 LEU   A CD2 1 
ATOM   235  N N   . SER   A 1 34  ? -7.17603  -8.08046  -38.56035 1.000 55.33517 ? 230 SER   A N   1 
ATOM   236  C CA  . SER   A 1 34  ? -8.36076  -8.27462  -39.38669 1.000 62.17606 ? 230 SER   A CA  1 
ATOM   237  C C   . SER   A 1 34  ? -8.35656  -7.31666  -40.57364 1.000 65.30225 ? 230 SER   A C   1 
ATOM   238  O O   . SER   A 1 34  ? -8.88711  -7.63011  -41.63938 1.000 68.09192 ? 230 SER   A O   1 
ATOM   239  C CB  . SER   A 1 34  ? -9.63148  -8.07992  -38.55755 1.000 64.82191 ? 230 SER   A CB  1 
ATOM   240  O OG  . SER   A 1 34  ? -9.54352  -6.91272  -37.75838 1.000 60.74985 ? 230 SER   A OG  1 
ATOM   241  N N   . PRO   A 1 42  ? -0.90655  -1.36523  -42.02604 1.000 53.07800 ? 238 PRO   A N   1 
ATOM   242  C CA  . PRO   A 1 42  ? -0.34425  -2.67777  -41.69719 1.000 50.98985 ? 238 PRO   A CA  1 
ATOM   243  C C   . PRO   A 1 42  ? 0.46507   -3.26814  -42.84786 1.000 48.80405 ? 238 PRO   A C   1 
ATOM   244  O O   . PRO   A 1 42  ? -0.04898  -4.09147  -43.60543 1.000 46.78862 ? 238 PRO   A O   1 
ATOM   245  C CB  . PRO   A 1 42  ? -1.58541  -3.52658  -41.41118 1.000 54.99853 ? 238 PRO   A CB  1 
ATOM   246  C CG  . PRO   A 1 42  ? -2.70855  -2.85441  -42.16947 1.000 60.23235 ? 238 PRO   A CG  1 
ATOM   247  C CD  . PRO   A 1 42  ? -2.26333  -1.47311  -42.58707 1.000 54.98934 ? 238 PRO   A CD  1 
ATOM   248  N N   . PHE   A 1 43  ? 1.72069   -2.84819  -42.97133 1.000 47.75501 ? 239 PHE   A N   1 
ATOM   249  C CA  . PHE   A 1 43  ? 2.55860   -3.31660  -44.06543 1.000 47.16726 ? 239 PHE   A CA  1 
ATOM   250  C C   . PHE   A 1 43  ? 3.01439   -4.74951  -43.81711 1.000 42.03920 ? 239 PHE   A C   1 
ATOM   251  O O   . PHE   A 1 43  ? 3.37521   -5.12023  -42.69663 1.000 40.11184 ? 239 PHE   A O   1 
ATOM   252  C CB  . PHE   A 1 43  ? 3.76905   -2.40193  -44.23530 1.000 48.74320 ? 239 PHE   A CB  1 
ATOM   253  C CG  . PHE   A 1 43  ? 4.63753   -2.76320  -45.40197 1.000 52.20751 ? 239 PHE   A CG  1 
ATOM   254  C CD1 . PHE   A 1 43  ? 4.19360   -2.57491  -46.70107 1.000 58.01479 ? 239 PHE   A CD1 1 
ATOM   255  C CD2 . PHE   A 1 43  ? 5.89266   -3.30418  -45.20134 1.000 55.02669 ? 239 PHE   A CD2 1 
ATOM   256  C CE1 . PHE   A 1 43  ? 4.99453   -2.91178  -47.77820 1.000 52.58495 ? 239 PHE   A CE1 1 
ATOM   257  C CE2 . PHE   A 1 43  ? 6.69481   -3.64217  -46.27109 1.000 50.66247 ? 239 PHE   A CE2 1 
ATOM   258  C CZ  . PHE   A 1 43  ? 6.24748   -3.44652  -47.56090 1.000 52.16951 ? 239 PHE   A CZ  1 
ATOM   259  N N   . VAL   A 1 44  ? 3.00373   -5.55543  -44.87554 1.000 42.35988 ? 240 VAL   A N   1 
ATOM   260  C CA  . VAL   A 1 44  ? 3.33875   -6.97248  -44.79440 1.000 42.84071 ? 240 VAL   A CA  1 
ATOM   261  C C   . VAL   A 1 44  ? 4.80368   -7.15760  -45.16283 1.000 43.65070 ? 240 VAL   A C   1 
ATOM   262  O O   . VAL   A 1 44  ? 5.25259   -6.69274  -46.21864 1.000 44.02266 ? 240 VAL   A O   1 
ATOM   263  C CB  . VAL   A 1 44  ? 2.43035   -7.81176  -45.70889 1.000 44.69907 ? 240 VAL   A CB  1 
ATOM   264  C CG1 . VAL   A 1 44  ? 2.88976   -9.26284  -45.73140 1.000 40.44826 ? 240 VAL   A CG1 1 
ATOM   265  C CG2 . VAL   A 1 44  ? 0.98373   -7.71074  -45.25095 1.000 43.20876 ? 240 VAL   A CG2 1 
ATOM   266  N N   . ILE   A 1 45  ? 5.54782   -7.83258  -44.29192 1.000 33.25909 ? 241 ILE   A N   1 
ATOM   267  C CA  . ILE   A 1 45  ? 6.94318   -8.18300  -44.52754 1.000 37.86408 ? 241 ILE   A CA  1 
ATOM   268  C C   . ILE   A 1 45  ? 6.99025   -9.67839  -44.80876 1.000 43.55621 ? 241 ILE   A C   1 
ATOM   269  O O   . ILE   A 1 45  ? 6.79798   -10.49458 -43.89860 1.000 36.10949 ? 241 ILE   A O   1 
ATOM   270  C CB  . ILE   A 1 45  ? 7.83416   -7.81672  -43.33322 1.000 35.65099 ? 241 ILE   A CB  1 
ATOM   271  C CG1 . ILE   A 1 45  ? 7.81983   -6.30595  -43.09361 1.000 40.36109 ? 241 ILE   A CG1 1 
ATOM   272  C CG2 . ILE   A 1 45  ? 9.25377   -8.31877  -43.55014 1.000 35.26944 ? 241 ILE   A CG2 1 
ATOM   273  C CD1 . ILE   A 1 45  ? 8.48382   -5.89374  -41.79563 1.000 33.70383 ? 241 ILE   A CD1 1 
ATOM   274  N N   . HIS   A 1 46  ? 7.24344   -10.04610 -46.06820 1.000 44.57319 ? 242 HIS   A N   1 
ATOM   275  C CA  . HIS   A 1 46  ? 7.28113   -11.44840 -46.45832 1.000 42.52576 ? 242 HIS   A CA  1 
ATOM   276  C C   . HIS   A 1 46  ? 8.55643   -11.85692 -47.18433 1.000 47.49439 ? 242 HIS   A C   1 
ATOM   277  O O   . HIS   A 1 46  ? 8.72472   -13.04731 -47.47134 1.000 47.89709 ? 242 HIS   A O   1 
ATOM   278  C CB  . HIS   A 1 46  ? 6.06728   -11.79635 -47.33636 1.000 42.69070 ? 242 HIS   A CB  1 
ATOM   279  C CG  . HIS   A 1 46  ? 5.99567   -11.01729 -48.61300 1.000 51.29552 ? 242 HIS   A CG  1 
ATOM   280  N ND1 . HIS   A 1 46  ? 6.75649   -11.32826 -49.71960 1.000 47.66280 ? 242 HIS   A ND1 1 
ATOM   281  C CD2 . HIS   A 1 46  ? 5.24594   -9.94489  -48.96157 1.000 50.04368 ? 242 HIS   A CD2 1 
ATOM   282  C CE1 . HIS   A 1 46  ? 6.48136   -10.47876 -50.69324 1.000 54.28449 ? 242 HIS   A CE1 1 
ATOM   283  N NE2 . HIS   A 1 46  ? 5.56818   -9.62890  -50.25900 1.000 55.69736 ? 242 HIS   A NE2 1 
ATOM   284  N N   . ASP   A 1 47  ? 9.45273   -10.92185 -47.48761 1.000 43.52232 ? 243 ASP   A N   1 
ATOM   285  C CA  . ASP   A 1 47  ? 10.71888  -11.24947 -48.13274 1.000 48.22176 ? 243 ASP   A CA  1 
ATOM   286  C C   . ASP   A 1 47  ? 11.74185  -10.17956 -47.76418 1.000 49.52396 ? 243 ASP   A C   1 
ATOM   287  O O   . ASP   A 1 47  ? 11.47267  -9.29131  -46.94968 1.000 45.35478 ? 243 ASP   A O   1 
ATOM   288  C CB  . ASP   A 1 47  ? 10.54272  -11.38236 -49.65202 1.000 55.23857 ? 243 ASP   A CB  1 
ATOM   289  C CG  . ASP   A 1 47  ? 9.79663   -10.20951 -50.26195 1.000 52.97245 ? 243 ASP   A CG  1 
ATOM   290  O OD1 . ASP   A 1 47  ? 9.54586   -9.21876  -49.54558 1.000 52.03172 ? 243 ASP   A OD1 1 
ATOM   291  O OD2 . ASP   A 1 47  ? 9.46392   -10.27704 -51.46387 1.000 54.50474 ? 243 ASP   A OD2 1 
ATOM   292  N N   . MET   A 1 48  ? 12.92803  -10.26822 -48.37148 1.000 49.79647 ? 244 MET   A N   1 
ATOM   293  C CA  . MET   A 1 48  ? 13.96406  -9.27312  -48.11728 1.000 45.88256 ? 244 MET   A CA  1 
ATOM   294  C C   . MET   A 1 48  ? 13.59959  -7.91912  -48.71126 1.000 47.20622 ? 244 MET   A C   1 
ATOM   295  O O   . MET   A 1 48  ? 14.03865  -6.88190  -48.20124 1.000 48.96519 ? 244 MET   A O   1 
ATOM   296  C CB  . MET   A 1 48  ? 15.30319  -9.75301  -48.67723 1.000 51.08454 ? 244 MET   A CB  1 
ATOM   297  C CG  . MET   A 1 48  ? 16.03991  -10.73627 -47.78321 1.000 51.89502 ? 244 MET   A CG  1 
ATOM   298  S SD  . MET   A 1 48  ? 16.01048  -10.26852 -46.04253 1.000 60.73382 ? 244 MET   A SD  1 
ATOM   299  C CE  . MET   A 1 48  ? 16.92037  -11.62872 -45.31389 1.000 49.11476 ? 244 MET   A CE  1 
ATOM   300  N N   . GLU   A 1 49  ? 12.80130  -7.90762  -49.78081 1.000 51.44300 ? 245 GLU   A N   1 
ATOM   301  C CA  . GLU   A 1 49  ? 12.41312  -6.64768  -50.40611 1.000 51.28353 ? 245 GLU   A CA  1 
ATOM   302  C C   . GLU   A 1 49  ? 11.43865  -5.87433  -49.52608 1.000 50.77639 ? 245 GLU   A C   1 
ATOM   303  O O   . GLU   A 1 49  ? 11.62931  -4.67865  -49.27358 1.000 47.16039 ? 245 GLU   A O   1 
ATOM   304  C CB  . GLU   A 1 49  ? 11.80339  -6.91317  -51.78317 1.000 53.20879 ? 245 GLU   A CB  1 
ATOM   305  C CG  . GLU   A 1 49  ? 11.83293  -5.71841  -52.72501 1.000 62.32812 ? 245 GLU   A CG  1 
ATOM   306  C CD  . GLU   A 1 49  ? 12.98009  -4.76882  -52.43444 1.000 71.11537 ? 245 GLU   A CD  1 
ATOM   307  O OE1 . GLU   A 1 49  ? 14.13040  -5.09525  -52.79687 1.000 75.75694 ? 245 GLU   A OE1 1 
ATOM   308  O OE2 . GLU   A 1 49  ? 12.73161  -3.69442  -51.84683 1.000 70.85946 ? 245 GLU   A OE2 1 
ATOM   309  N N   . THR   A 1 50  ? 10.38326  -6.54105  -49.04982 1.000 45.46053 ? 246 THR   A N   1 
ATOM   310  C CA  . THR   A 1 50  ? 9.40927   -5.86108  -48.20230 1.000 43.34856 ? 246 THR   A CA  1 
ATOM   311  C C   . THR   A 1 50  ? 9.99822   -5.50656  -46.84321 1.000 39.93756 ? 246 THR   A C   1 
ATOM   312  O O   . THR   A 1 50  ? 9.56211   -4.53508  -46.21653 1.000 45.06906 ? 246 THR   A O   1 
ATOM   313  C CB  . THR   A 1 50  ? 8.15693   -6.72254  -48.02992 1.000 39.93880 ? 246 THR   A CB  1 
ATOM   314  O OG1 . THR   A 1 50  ? 8.53638   -8.07902  -47.76804 1.000 40.88372 ? 246 THR   A OG1 1 
ATOM   315  C CG2 . THR   A 1 50  ? 7.30304   -6.67396  -49.28769 1.000 39.29715 ? 246 THR   A CG2 1 
ATOM   316  N N   . LEU   A 1 51  ? 10.98590  -6.27041  -46.37289 1.000 41.99088 ? 247 LEU   A N   1 
ATOM   317  C CA  . LEU   A 1 51  ? 11.64547  -5.92347  -45.11882 1.000 42.91385 ? 247 LEU   A CA  1 
ATOM   318  C C   . LEU   A 1 51  ? 12.35225  -4.57859  -45.23359 1.000 46.54369 ? 247 LEU   A C   1 
ATOM   319  O O   . LEU   A 1 51  ? 12.20320  -3.70888  -44.36745 1.000 39.50155 ? 247 LEU   A O   1 
ATOM   320  C CB  . LEU   A 1 51  ? 12.62918  -7.02297  -44.71816 1.000 36.84976 ? 247 LEU   A CB  1 
ATOM   321  C CG  . LEU   A 1 51  ? 13.55156  -6.69130  -43.54292 1.000 36.40026 ? 247 LEU   A CG  1 
ATOM   322  C CD1 . LEU   A 1 51  ? 12.76189  -6.60758  -42.24440 1.000 38.81711 ? 247 LEU   A CD1 1 
ATOM   323  C CD2 . LEU   A 1 51  ? 14.66450  -7.71750  -43.42922 1.000 43.87707 ? 247 LEU   A CD2 1 
ATOM   324  N N   . CYS   A 1 52  ? 13.11996  -4.38600  -46.30997 1.000 44.72264 ? 248 CYS   A N   1 
ATOM   325  C CA  . CYS   A 1 52  ? 13.77906  -3.10290  -46.52953 1.000 46.06036 ? 248 CYS   A CA  1 
ATOM   326  C C   . CYS   A 1 52  ? 12.77082  -1.99326  -46.79643 1.000 41.09615 ? 248 CYS   A C   1 
ATOM   327  O O   . CYS   A 1 52  ? 13.00728  -0.83925  -46.42071 1.000 42.09910 ? 248 CYS   A O   1 
ATOM   328  C CB  . CYS   A 1 52  ? 14.76739  -3.21177  -47.69046 1.000 45.96328 ? 248 CYS   A CB  1 
ATOM   329  S SG  . CYS   A 1 52  ? 16.08067  -4.42529  -47.43471 1.000 60.44407 ? 248 CYS   A SG  1 
ATOM   330  N N   . MET   A 1 53  ? 11.64958  -2.31912  -47.44372 1.000 41.21288 ? 249 MET   A N   1 
ATOM   331  C CA  . MET   A 1 53  ? 10.60739  -1.32296  -47.66453 1.000 46.28474 ? 249 MET   A CA  1 
ATOM   332  C C   . MET   A 1 53  ? 10.03277  -0.82985  -46.34233 1.000 46.40701 ? 249 MET   A C   1 
ATOM   333  O O   . MET   A 1 53  ? 9.79921   0.37194   -46.16674 1.000 41.64655 ? 249 MET   A O   1 
ATOM   334  C CB  . MET   A 1 53  ? 9.50430   -1.90871  -48.54676 1.000 48.18918 ? 249 MET   A CB  1 
ATOM   335  C CG  . MET   A 1 53  ? 8.63908   -0.87151  -49.24465 1.000 51.13633 ? 249 MET   A CG  1 
ATOM   336  S SD  . MET   A 1 53  ? 9.53686   0.63843   -49.65379 1.000 82.39582 ? 249 MET   A SD  1 
ATOM   337  C CE  . MET   A 1 53  ? 10.05566  0.28674   -51.33248 1.000 54.52515 ? 249 MET   A CE  1 
ATOM   338  N N   . ALA   A 1 54  ? 9.80890   -1.74418  -45.39524 1.000 41.32996 ? 250 ALA   A N   1 
ATOM   339  C CA  . ALA   A 1 54  ? 9.25509   -1.35336  -44.10310 1.000 45.97238 ? 250 ALA   A CA  1 
ATOM   340  C C   . ALA   A 1 54  ? 10.27514  -0.59076  -43.26809 1.000 40.33295 ? 250 ALA   A C   1 
ATOM   341  O O   . ALA   A 1 54  ? 9.92654   0.38564   -42.59395 1.000 42.30242 ? 250 ALA   A O   1 
ATOM   342  C CB  . ALA   A 1 54  ? 8.76235   -2.58681  -43.34828 1.000 41.00729 ? 250 ALA   A CB  1 
ATOM   343  N N   . GLU   A 1 55  ? 11.53861  -1.02262  -43.29499 1.000 39.53389 ? 251 GLU   A N   1 
ATOM   344  C CA  . GLU   A 1 55  ? 12.57091  -0.35838  -42.50824 1.000 41.02202 ? 251 GLU   A CA  1 
ATOM   345  C C   . GLU   A 1 55  ? 12.84033  1.06171   -42.98611 1.000 46.84720 ? 251 GLU   A C   1 
ATOM   346  O O   . GLU   A 1 55  ? 13.30562  1.88963   -42.19558 1.000 44.05709 ? 251 GLU   A O   1 
ATOM   347  C CB  . GLU   A 1 55  ? 13.86428  -1.17481  -42.53975 1.000 44.19449 ? 251 GLU   A CB  1 
ATOM   348  C CG  . GLU   A 1 55  ? 13.76710  -2.51563  -41.82757 1.000 45.65551 ? 251 GLU   A CG  1 
ATOM   349  C CD  . GLU   A 1 55  ? 14.96990  -3.40270  -42.08442 1.000 50.07367 ? 251 GLU   A CD  1 
ATOM   350  O OE1 . GLU   A 1 55  ? 15.22460  -3.73444  -43.26160 1.000 47.58049 ? 251 GLU   A OE1 1 
ATOM   351  O OE2 . GLU   A 1 55  ? 15.65895  -3.77169  -41.10962 1.000 44.03333 ? 251 GLU   A OE2 1 
ATOM   352  N N   . LYS   A 1 56  ? 12.55578  1.36212   -44.25547 1.000 45.99160 ? 252 LYS   A N   1 
ATOM   353  C CA  . LYS   A 1 56  ? 12.74703  2.71364   -44.76588 1.000 51.83404 ? 252 LYS   A CA  1 
ATOM   354  C C   . LYS   A 1 56  ? 11.80423  3.71713   -44.11656 1.000 52.41032 ? 252 LYS   A C   1 
ATOM   355  O O   . LYS   A 1 56  ? 12.09192  4.91885   -44.13249 1.000 56.33625 ? 252 LYS   A O   1 
ATOM   356  C CB  . LYS   A 1 56  ? 12.55474  2.73550   -46.28296 1.000 48.16121 ? 252 LYS   A CB  1 
ATOM   357  C CG  . LYS   A 1 56  ? 13.80403  2.40034   -47.07748 1.000 48.62757 ? 252 LYS   A CG  1 
ATOM   358  C CD  . LYS   A 1 56  ? 13.69206  2.90770   -48.50546 1.000 52.81849 ? 252 LYS   A CD  1 
ATOM   359  C CE  . LYS   A 1 56  ? 14.27616  1.91387   -49.49482 1.000 49.63487 ? 252 LYS   A CE  1 
ATOM   360  N NZ  . LYS   A 1 56  ? 13.58228  1.97698   -50.81045 1.000 48.72955 ? 252 LYS   A NZ  1 
ATOM   361  N N   . THR   A 1 57  ? 10.69071  3.25422   -43.54483 1.000 47.16999 ? 253 THR   A N   1 
ATOM   362  C CA  . THR   A 1 57  ? 9.70060   4.13966   -42.95151 1.000 48.52343 ? 253 THR   A CA  1 
ATOM   363  C C   . THR   A 1 57  ? 9.57220   3.99743   -41.44183 1.000 48.53977 ? 253 THR   A C   1 
ATOM   364  O O   . THR   A 1 57  ? 9.13947   4.94980   -40.78625 1.000 54.03418 ? 253 THR   A O   1 
ATOM   365  C CB  . THR   A 1 57  ? 8.32220   3.89614   -43.58564 1.000 50.99276 ? 253 THR   A CB  1 
ATOM   366  O OG1 . THR   A 1 57  ? 8.48388   3.56286   -44.96993 1.000 54.13566 ? 253 THR   A OG1 1 
ATOM   367  C CG2 . THR   A 1 57  ? 7.45461   5.14018   -43.47314 1.000 57.71338 ? 253 THR   A CG2 1 
ATOM   368  N N   . LEU   A 1 58  ? 9.94189   2.84928   -40.87356 1.000 45.77604 ? 254 LEU   A N   1 
ATOM   369  C CA  . LEU   A 1 58  ? 9.71506   2.58453   -39.46049 1.000 49.94416 ? 254 LEU   A CA  1 
ATOM   370  C C   . LEU   A 1 58  ? 10.98602  2.54682   -38.62265 1.000 52.89583 ? 254 LEU   A C   1 
ATOM   371  O O   . LEU   A 1 58  ? 10.88919  2.45998   -37.39319 1.000 45.30307 ? 254 LEU   A O   1 
ATOM   372  C CB  . LEU   A 1 58  ? 8.95740   1.25915   -39.28839 1.000 42.02228 ? 254 LEU   A CB  1 
ATOM   373  C CG  . LEU   A 1 58  ? 7.66228   1.13473   -40.09504 1.000 48.55043 ? 254 LEU   A CG  1 
ATOM   374  C CD1 . LEU   A 1 58  ? 7.09640   -0.27356  -39.99829 1.000 41.86872 ? 254 LEU   A CD1 1 
ATOM   375  C CD2 . LEU   A 1 58  ? 6.63765   2.16410   -39.63614 1.000 44.25567 ? 254 LEU   A CD2 1 
ATOM   376  N N   . VAL   A 1 59  ? 12.16452  2.60413   -39.23951 1.000 46.74319 ? 255 VAL   A N   1 
ATOM   377  C CA  . VAL   A 1 59  ? 13.43298  2.60737   -38.52073 1.000 50.05829 ? 255 VAL   A CA  1 
ATOM   378  C C   . VAL   A 1 59  ? 14.20306  3.86563   -38.89484 1.000 60.25744 ? 255 VAL   A C   1 
ATOM   379  O O   . VAL   A 1 59  ? 14.20079  4.28400   -40.05789 1.000 57.25306 ? 255 VAL   A O   1 
ATOM   380  C CB  . VAL   A 1 59  ? 14.27089  1.34639   -38.82063 1.000 58.28259 ? 255 VAL   A CB  1 
ATOM   381  C CG1 . VAL   A 1 59  ? 15.31787  1.13789   -37.73718 1.000 54.23478 ? 255 VAL   A CG1 1 
ATOM   382  C CG2 . VAL   A 1 59  ? 13.37462  0.12346   -38.93492 1.000 56.11562 ? 255 VAL   A CG2 1 
ATOM   383  N N   . ALA   A 1 60  ? 14.86225  4.46369   -37.90728 1.000 58.13801 ? 256 ALA   A N   1 
ATOM   384  C CA  . ALA   A 1 60  ? 15.63089  5.68142   -38.10960 1.000 59.81712 ? 256 ALA   A CA  1 
ATOM   385  C C   . ALA   A 1 60  ? 17.05704  5.35811   -38.54815 1.000 68.78090 ? 256 ALA   A C   1 
ATOM   386  O O   . ALA   A 1 60  ? 17.58704  4.27533   -38.28667 1.000 64.52087 ? 256 ALA   A O   1 
ATOM   387  C CB  . ALA   A 1 60  ? 15.65267  6.52244   -36.83240 1.000 55.43283 ? 256 ALA   A CB  1 
ATOM   388  N N   . LYS   A 1 61  ? 17.67659  6.32390   -39.22211 1.000 73.32915 ? 257 LYS   A N   1 
ATOM   389  C CA  . LYS   A 1 61  ? 19.03851  6.19904   -39.72218 1.000 73.28344 ? 257 LYS   A CA  1 
ATOM   390  C C   . LYS   A 1 61  ? 19.97719  7.06799   -38.89533 1.000 74.73207 ? 257 LYS   A C   1 
ATOM   391  O O   . LYS   A 1 61  ? 19.65154  8.21333   -38.56780 1.000 76.31483 ? 257 LYS   A O   1 
ATOM   392  C CB  . LYS   A 1 61  ? 19.12318  6.60317   -41.19785 1.000 72.92555 ? 257 LYS   A CB  1 
ATOM   393  C CG  . LYS   A 1 61  ? 18.11898  5.90540   -42.10350 1.000 69.78975 ? 257 LYS   A CG  1 
ATOM   394  C CD  . LYS   A 1 61  ? 18.09967  4.40274   -41.86943 1.000 72.61710 ? 257 LYS   A CD  1 
ATOM   395  C CE  . LYS   A 1 61  ? 17.52200  3.66768   -43.06899 1.000 70.06716 ? 257 LYS   A CE  1 
ATOM   396  N NZ  . LYS   A 1 61  ? 18.24083  4.00651   -44.32871 1.000 70.87815 ? 257 LYS   A NZ  1 
ATOM   397  N N   . LEU   A 1 62  ? 21.14231  6.52128   -38.56277 1.000 77.52797 ? 258 LEU   A N   1 
ATOM   398  C CA  . LEU   A 1 62  ? 22.13192  7.25202   -37.77758 1.000 70.69242 ? 258 LEU   A CA  1 
ATOM   399  C C   . LEU   A 1 62  ? 23.47933  7.27920   -38.49210 1.000 65.83741 ? 258 LEU   A C   1 
ATOM   400  O O   . LEU   A 1 62  ? 23.76369  8.19151   -39.26800 1.000 69.30938 ? 258 LEU   A O   1 
ATOM   401  C CB  . LEU   A 1 62  ? 22.28920  6.63276   -36.38497 1.000 64.08349 ? 258 LEU   A CB  1 
ATOM   402  C CG  . LEU   A 1 62  ? 21.01800  6.30000   -35.59852 1.000 66.92023 ? 258 LEU   A CG  1 
ATOM   403  C CD1 . LEU   A 1 62  ? 20.59166  4.85912   -35.84595 1.000 66.50791 ? 258 LEU   A CD1 1 
ATOM   404  C CD2 . LEU   A 1 62  ? 21.21598  6.55854   -34.11175 1.000 55.65386 ? 258 LEU   A CD2 1 
ATOM   405  N N   . ASN   A 1 69  ? 23.00304  -1.09414  -41.65702 1.000 61.34261 ? 265 ASN   A N   1 
ATOM   406  C CA  . ASN   A 1 69  ? 24.26209  -1.56499  -42.22052 1.000 67.29881 ? 265 ASN   A CA  1 
ATOM   407  C C   . ASN   A 1 69  ? 24.45245  -3.04735  -41.90883 1.000 68.18951 ? 265 ASN   A C   1 
ATOM   408  O O   . ASN   A 1 69  ? 25.00069  -3.79651  -42.71781 1.000 70.05095 ? 265 ASN   A O   1 
ATOM   409  C CB  . ASN   A 1 69  ? 25.43563  -0.74381  -41.67606 1.000 68.58366 ? 265 ASN   A CB  1 
ATOM   410  C CG  . ASN   A 1 69  ? 26.76699  -1.46038  -41.81111 1.000 79.34921 ? 265 ASN   A CG  1 
ATOM   411  O OD1 . ASN   A 1 69  ? 27.10461  -1.97448  -42.87857 1.000 84.34635 ? 265 ASN   A OD1 1 
ATOM   412  N ND2 . ASN   A 1 69  ? 27.52962  -1.50073  -40.72462 1.000 78.88245 ? 265 ASN   A ND2 1 
ATOM   413  N N   . LYS   A 1 70  ? 23.98206  -3.46709  -40.73608 1.000 64.25358 ? 266 LYS   A N   1 
ATOM   414  C CA  . LYS   A 1 70  ? 24.12789  -4.85238  -40.31851 1.000 56.79729 ? 266 LYS   A CA  1 
ATOM   415  C C   . LYS   A 1 70  ? 23.23107  -5.76693  -41.15340 1.000 51.42203 ? 266 LYS   A C   1 
ATOM   416  O O   . LYS   A 1 70  ? 22.37775  -5.32078  -41.92621 1.000 53.43189 ? 266 LYS   A O   1 
ATOM   417  C CB  . LYS   A 1 70  ? 23.79955  -5.00495  -38.83359 1.000 57.77646 ? 266 LYS   A CB  1 
ATOM   418  C CG  . LYS   A 1 70  ? 24.63417  -4.13224  -37.91196 1.000 61.07856 ? 266 LYS   A CG  1 
ATOM   419  C CD  . LYS   A 1 70  ? 23.76403  -3.44105  -36.87573 1.000 66.07303 ? 266 LYS   A CD  1 
ATOM   420  C CE  . LYS   A 1 70  ? 24.56013  -3.09308  -35.62827 1.000 70.05614 ? 266 LYS   A CE  1 
ATOM   421  N NZ  . LYS   A 1 70  ? 23.67516  -2.68650  -34.50125 1.000 71.37538 ? 266 LYS   A NZ  1 
ATOM   422  N N   . GLU   A 1 71  ? 23.43651  -7.07038  -40.98208 1.000 47.14551 ? 267 GLU   A N   1 
ATOM   423  C CA  . GLU   A 1 71  ? 22.67013  -8.06253  -41.72133 1.000 46.33421 ? 267 GLU   A CA  1 
ATOM   424  C C   . GLU   A 1 71  ? 21.20388  -8.03432  -41.29921 1.000 48.05699 ? 267 GLU   A C   1 
ATOM   425  O O   . GLU   A 1 71  ? 20.86537  -7.65868  -40.17371 1.000 50.22607 ? 267 GLU   A O   1 
ATOM   426  C CB  . GLU   A 1 71  ? 23.26025  -9.45654  -41.50120 1.000 48.42583 ? 267 GLU   A CB  1 
ATOM   427  C CG  . GLU   A 1 71  ? 22.69290  -10.53475 -42.40944 1.000 51.83879 ? 267 GLU   A CG  1 
ATOM   428  C CD  . GLU   A 1 71  ? 23.38996  -11.86869 -42.23635 1.000 54.38530 ? 267 GLU   A CD  1 
ATOM   429  O OE1 . GLU   A 1 71  ? 23.94543  -12.11241 -41.14470 1.000 45.48439 ? 267 GLU   A OE1 1 
ATOM   430  O OE2 . GLU   A 1 71  ? 23.37825  -12.67588 -43.18996 1.000 61.34322 ? 267 GLU   A OE2 1 
ATOM   431  N N   . ALA   A 1 72  ? 20.33049  -8.44376  -42.22504 1.000 43.94000 ? 268 ALA   A N   1 
ATOM   432  C CA  . ALA   A 1 72  ? 18.89117  -8.37229  -41.98811 1.000 47.97104 ? 268 ALA   A CA  1 
ATOM   433  C C   . ALA   A 1 72  ? 18.48149  -9.17072  -40.75642 1.000 47.87245 ? 268 ALA   A C   1 
ATOM   434  O O   . ALA   A 1 72  ? 17.56975  -8.76862  -40.02385 1.000 42.94899 ? 268 ALA   A O   1 
ATOM   435  C CB  . ALA   A 1 72  ? 18.13566  -8.86567  -43.22108 1.000 45.39979 ? 268 ALA   A CB  1 
ATOM   436  N N   . GLU   A 1 73  ? 19.14025  -10.30654 -40.51256 1.000 49.15792 ? 269 GLU   A N   1 
ATOM   437  C CA  . GLU   A 1 73  ? 18.82893  -11.09890 -39.32681 1.000 47.75292 ? 269 GLU   A CA  1 
ATOM   438  C C   . GLU   A 1 73  ? 19.16865  -10.33805 -38.05138 1.000 48.33590 ? 269 GLU   A C   1 
ATOM   439  O O   . GLU   A 1 73  ? 18.46732  -10.46136 -37.04002 1.000 40.12983 ? 269 GLU   A O   1 
ATOM   440  C CB  . GLU   A 1 73  ? 19.57801  -12.43105 -39.37294 1.000 48.10758 ? 269 GLU   A CB  1 
ATOM   441  C CG  . GLU   A 1 73  ? 18.93217  -13.48241 -40.26215 1.000 51.63423 ? 269 GLU   A CG  1 
ATOM   442  C CD  . GLU   A 1 73  ? 19.20094  -13.24919 -41.73682 1.000 54.66869 ? 269 GLU   A CD  1 
ATOM   443  O OE1 . GLU   A 1 73  ? 20.04423  -12.38698 -42.06209 1.000 49.11959 ? 269 GLU   A OE1 1 
ATOM   444  O OE2 . GLU   A 1 73  ? 18.56884  -13.93004 -42.57181 1.000 53.26068 ? 269 GLU   A OE2 1 
ATOM   445  N N   . VAL   A 1 74  ? 20.24150  -9.54317  -38.08119 1.000 43.37741 ? 270 VAL   A N   1 
ATOM   446  C CA  . VAL   A 1 74  ? 20.61410  -8.75109  -36.91368 1.000 43.49307 ? 270 VAL   A CA  1 
ATOM   447  C C   . VAL   A 1 74  ? 19.68493  -7.55366  -36.75385 1.000 46.91498 ? 270 VAL   A C   1 
ATOM   448  O O   . VAL   A 1 74  ? 19.42948  -7.10236  -35.62971 1.000 45.56704 ? 270 VAL   A O   1 
ATOM   449  C CB  . VAL   A 1 74  ? 22.08723  -8.31411  -37.01769 1.000 47.30438 ? 270 VAL   A CB  1 
ATOM   450  C CG1 . VAL   A 1 74  ? 22.56081  -7.70640  -35.70472 1.000 48.91501 ? 270 VAL   A CG1 1 
ATOM   451  C CG2 . VAL   A 1 74  ? 22.96070  -9.49402  -37.41479 1.000 49.85405 ? 270 VAL   A CG2 1 
ATOM   452  N N   . ARG   A 1 75  ? 19.16551  -7.01858  -37.86230 1.000 39.57091 ? 271 ARG   A N   1 
ATOM   453  C CA  . ARG   A 1 75  ? 18.23748  -5.89477  -37.77380 1.000 42.56648 ? 271 ARG   A CA  1 
ATOM   454  C C   . ARG   A 1 75  ? 16.92815  -6.31190  -37.11449 1.000 39.85713 ? 271 ARG   A C   1 
ATOM   455  O O   . ARG   A 1 75  ? 16.40528  -5.59613  -36.25186 1.000 35.94237 ? 271 ARG   A O   1 
ATOM   456  C CB  . ARG   A 1 75  ? 17.97895  -5.31249  -39.16425 1.000 36.60761 ? 271 ARG   A CB  1 
ATOM   457  C CG  . ARG   A 1 75  ? 19.24094  -4.95945  -39.93875 1.000 40.77536 ? 271 ARG   A CG  1 
ATOM   458  C CD  . ARG   A 1 75  ? 18.97030  -3.90556  -41.00233 1.000 41.33534 ? 271 ARG   A CD  1 
ATOM   459  N NE  . ARG   A 1 75  ? 18.02434  -4.36927  -42.01067 1.000 39.59432 ? 271 ARG   A NE  1 
ATOM   460  C CZ  . ARG   A 1 75  ? 18.36625  -4.95804  -43.14903 1.000 45.30067 ? 271 ARG   A CZ  1 
ATOM   461  N NH1 . ARG   A 1 75  ? 19.63295  -5.18164  -43.45958 1.000 44.31694 ? 271 ARG   A NH1 1 
ATOM   462  N NH2 . ARG   A 1 75  ? 17.41295  -5.33081  -43.99807 1.000 43.21915 ? 271 ARG   A NH2 1 
ATOM   463  N N   . ILE   A 1 76  ? 16.38283  -7.46568  -37.50831 1.000 41.38774 ? 272 ILE   A N   1 
ATOM   464  C CA  . ILE   A 1 76  ? 15.18185  -7.97676  -36.85573 1.000 42.21975 ? 272 ILE   A CA  1 
ATOM   465  C C   . ILE   A 1 76  ? 15.48041  -8.35380  -35.41126 1.000 44.24548 ? 272 ILE   A C   1 
ATOM   466  O O   . ILE   A 1 76  ? 14.62548  -8.19789  -34.53025 1.000 44.66539 ? 272 ILE   A O   1 
ATOM   467  C CB  . ILE   A 1 76  ? 14.61274  -9.16891  -37.64696 1.000 39.12599 ? 272 ILE   A CB  1 
ATOM   468  C CG1 . ILE   A 1 76  ? 14.41740  -8.78693  -39.11522 1.000 36.34716 ? 272 ILE   A CG1 1 
ATOM   469  C CG2 . ILE   A 1 76  ? 13.30088  -9.64337  -37.03839 1.000 40.29165 ? 272 ILE   A CG2 1 
ATOM   470  C CD1 . ILE   A 1 76  ? 14.01868  -9.94832  -40.00089 1.000 38.30664 ? 272 ILE   A CD1 1 
ATOM   471  N N   . PHE   A 1 77  ? 16.69249  -8.84495  -35.14365 1.000 44.68797 ? 273 PHE   A N   1 
ATOM   472  C CA  . PHE   A 1 77  ? 17.08806  -9.17881  -33.77917 1.000 42.65716 ? 273 PHE   A CA  1 
ATOM   473  C C   . PHE   A 1 77  ? 17.06535  -7.94369  -32.88631 1.000 46.03896 ? 273 PHE   A C   1 
ATOM   474  O O   . PHE   A 1 77  ? 16.52284  -7.97416  -31.77540 1.000 43.73267 ? 273 PHE   A O   1 
ATOM   475  C CB  . PHE   A 1 77  ? 18.47688  -9.82655  -33.79624 1.000 39.29914 ? 273 PHE   A CB  1 
ATOM   476  C CG  . PHE   A 1 77  ? 19.22917  -9.71644  -32.49686 1.000 45.66864 ? 273 PHE   A CG  1 
ATOM   477  C CD1 . PHE   A 1 77  ? 19.09843  -10.69212 -31.52313 1.000 47.31849 ? 273 PHE   A CD1 1 
ATOM   478  C CD2 . PHE   A 1 77  ? 20.09341  -8.65583  -32.26258 1.000 47.63554 ? 273 PHE   A CD2 1 
ATOM   479  C CE1 . PHE   A 1 77  ? 19.79679  -10.60149 -30.33284 1.000 46.99357 ? 273 PHE   A CE1 1 
ATOM   480  C CE2 . PHE   A 1 77  ? 20.78843  -8.55764  -31.07210 1.000 49.43441 ? 273 PHE   A CE2 1 
ATOM   481  C CZ  . PHE   A 1 77  ? 20.64129  -9.53331  -30.10695 1.000 50.86166 ? 273 PHE   A CZ  1 
ATOM   482  N N   . HIS   A 1 78  ? 17.64934  -6.84099  -33.36166 1.000 46.68518 ? 274 HIS   A N   1 
ATOM   483  C CA  . HIS   A 1 78  ? 17.69511  -5.62311  -32.55934 1.000 45.90812 ? 274 HIS   A CA  1 
ATOM   484  C C   . HIS   A 1 78  ? 16.30588  -5.02380  -32.38168 1.000 41.73353 ? 274 HIS   A C   1 
ATOM   485  O O   . HIS   A 1 78  ? 15.98763  -4.48779  -31.31380 1.000 42.54905 ? 274 HIS   A O   1 
ATOM   486  C CB  . HIS   A 1 78  ? 18.64079  -4.60815  -33.20076 1.000 44.40565 ? 274 HIS   A CB  1 
ATOM   487  C CG  . HIS   A 1 78  ? 18.79493  -3.34551  -32.41217 1.000 50.00925 ? 274 HIS   A CG  1 
ATOM   488  N ND1 . HIS   A 1 78  ? 19.38025  -3.31411  -31.16474 1.000 51.43311 ? 274 HIS   A ND1 1 
ATOM   489  C CD2 . HIS   A 1 78  ? 18.43924  -2.06944  -32.69305 1.000 53.68105 ? 274 HIS   A CD2 1 
ATOM   490  C CE1 . HIS   A 1 78  ? 19.37861  -2.07328  -30.71103 1.000 55.44382 ? 274 HIS   A CE1 1 
ATOM   491  N NE2 . HIS   A 1 78  ? 18.81353  -1.29833  -31.61934 1.000 55.47875 ? 274 HIS   A NE2 1 
ATOM   492  N N   . CYS   A 1 79  ? 15.46592  -5.10343  -33.41613 1.000 36.62570 ? 275 CYS   A N   1 
ATOM   493  C CA  . CYS   A 1 79  ? 14.10707  -4.58321  -33.30482 1.000 42.72580 ? 275 CYS   A CA  1 
ATOM   494  C C   . CYS   A 1 79  ? 13.28340  -5.39713  -32.31479 1.000 41.08336 ? 275 CYS   A C   1 
ATOM   495  O O   . CYS   A 1 79  ? 12.48921  -4.83661  -31.54984 1.000 39.83350 ? 275 CYS   A O   1 
ATOM   496  C CB  . CYS   A 1 79  ? 13.43677  -4.57049  -34.67834 1.000 33.83034 ? 275 CYS   A CB  1 
ATOM   497  S SG  . CYS   A 1 79  ? 11.64928  -4.29406  -34.63832 1.000 54.01433 ? 275 CYS   A SG  1 
ATOM   498  N N   . CYS   A 1 80  ? 13.46274  -6.71970  -32.31075 1.000 33.81360 ? 276 CYS   A N   1 
ATOM   499  C CA  . CYS   A 1 80  ? 12.70047  -7.56649  -31.39912 1.000 36.97884 ? 276 CYS   A CA  1 
ATOM   500  C C   . CYS   A 1 80  ? 13.17303  -7.40076  -29.96101 1.000 32.50126 ? 276 CYS   A C   1 
ATOM   501  O O   . CYS   A 1 80  ? 12.35384  -7.33191  -29.03738 1.000 33.59805 ? 276 CYS   A O   1 
ATOM   502  C CB  . CYS   A 1 80  ? 12.80244  -9.02790  -31.83334 1.000 34.82678 ? 276 CYS   A CB  1 
ATOM   503  S SG  . CYS   A 1 80  ? 11.78510  -9.43868  -33.26573 1.000 41.71770 ? 276 CYS   A SG  1 
ATOM   504  N N   . GLN   A 1 81  ? 14.48926  -7.33539  -29.74811 1.000 37.93127 ? 277 GLN   A N   1 
ATOM   505  C CA  . GLN   A 1 81  ? 14.99623  -7.16626  -28.39144 1.000 34.94389 ? 277 GLN   A CA  1 
ATOM   506  C C   . GLN   A 1 81  ? 14.65997  -5.78632  -27.83839 1.000 37.73121 ? 277 GLN   A C   1 
ATOM   507  O O   . GLN   A 1 81  ? 14.46151  -5.63825  -26.62669 1.000 29.05998 ? 277 GLN   A O   1 
ATOM   508  C CB  . GLN   A 1 81  ? 16.50446  -7.42777  -28.35813 1.000 44.86450 ? 277 GLN   A CB  1 
ATOM   509  C CG  . GLN   A 1 81  ? 17.38272  -6.19374  -28.44981 1.000 38.28056 ? 277 GLN   A CG  1 
ATOM   510  C CD  . GLN   A 1 81  ? 18.82331  -6.48263  -28.07591 1.000 45.77550 ? 277 GLN   A CD  1 
ATOM   511  O OE1 . GLN   A 1 81  ? 19.09432  -7.21432  -27.12369 1.000 42.47619 ? 277 GLN   A OE1 1 
ATOM   512  N NE2 . GLN   A 1 81  ? 19.75664  -5.91122  -28.82829 1.000 46.05821 ? 277 GLN   A NE2 1 
ATOM   513  N N   . CYS   A 1 82  ? 14.56807  -4.77304  -28.70434 1.000 37.98078 ? 278 CYS   A N   1 
ATOM   514  C CA  . CYS   A 1 82  ? 14.13273  -3.45899  -28.24579 1.000 34.33692 ? 278 CYS   A CA  1 
ATOM   515  C C   . CYS   A 1 82  ? 12.67515  -3.49323  -27.80414 1.000 33.34078 ? 278 CYS   A C   1 
ATOM   516  O O   . CYS   A 1 82  ? 12.31329  -2.88058  -26.79374 1.000 33.56728 ? 278 CYS   A O   1 
ATOM   517  C CB  . CYS   A 1 82  ? 14.34394  -2.41935  -29.34577 1.000 44.21721 ? 278 CYS   A CB  1 
ATOM   518  S SG  . CYS   A 1 82  ? 16.02836  -1.75686  -29.42313 1.000 40.55622 ? 278 CYS   A SG  1 
ATOM   519  N N   . THR   A 1 83  ? 11.82780  -4.21368  -28.54360 1.000 31.64586 ? 279 THR   A N   1 
ATOM   520  C CA  . THR   A 1 83  ? 10.44024  -4.38610  -28.12564 1.000 33.84862 ? 279 THR   A CA  1 
ATOM   521  C C   . THR   A 1 83  ? 10.36001  -5.05847  -26.76071 1.000 29.39105 ? 279 THR   A C   1 
ATOM   522  O O   . THR   A 1 83  ? 9.51375   -4.70166  -25.93240 1.000 27.17513 ? 279 THR   A O   1 
ATOM   523  C CB  . THR   A 1 83  ? 9.67493   -5.19944  -29.17091 1.000 35.81080 ? 279 THR   A CB  1 
ATOM   524  O OG1 . THR   A 1 83  ? 9.78751   -4.56291  -30.44936 1.000 34.76603 ? 279 THR   A OG1 1 
ATOM   525  C CG2 . THR   A 1 83  ? 8.20309   -5.31100  -28.79642 1.000 34.85636 ? 279 THR   A CG2 1 
ATOM   526  N N   . SER   A 1 84  ? 11.24369  -6.02718  -26.50442 1.000 28.09060 ? 280 SER   A N   1 
ATOM   527  C CA  . SER   A 1 84  ? 11.26026  -6.69250  -25.20572 1.000 27.18129 ? 280 SER   A CA  1 
ATOM   528  C C   . SER   A 1 84  ? 11.62775  -5.72231  -24.09017 1.000 27.86624 ? 280 SER   A C   1 
ATOM   529  O O   . SER   A 1 84  ? 11.07054  -5.79707  -22.98888 1.000 26.79918 ? 280 SER   A O   1 
ATOM   530  C CB  . SER   A 1 84  ? 12.23460  -7.87055  -25.23131 1.000 26.81756 ? 280 SER   A CB  1 
ATOM   531  O OG  . SER   A 1 84  ? 11.73572  -8.93038  -26.02846 1.000 27.85472 ? 280 SER   A OG  1 
ATOM   532  N N   . VAL   A 1 85  ? 12.55870  -4.80255  -24.35847 1.000 30.73186 ? 281 VAL   A N   1 
ATOM   533  C CA  . VAL   A 1 85  ? 12.99373  -3.85379  -23.33567 1.000 28.40045 ? 281 VAL   A CA  1 
ATOM   534  C C   . VAL   A 1 85  ? 11.83013  -2.97129  -22.89777 1.000 27.42732 ? 281 VAL   A C   1 
ATOM   535  O O   . VAL   A 1 85  ? 11.61395  -2.74825  -21.70021 1.000 29.02325 ? 281 VAL   A O   1 
ATOM   536  C CB  . VAL   A 1 85  ? 14.17774  -3.01551  -23.85039 1.000 30.33720 ? 281 VAL   A CB  1 
ATOM   537  C CG1 . VAL   A 1 85  ? 14.36664  -1.77641  -22.98982 1.000 30.52016 ? 281 VAL   A CG1 1 
ATOM   538  C CG2 . VAL   A 1 85  ? 15.44734  -3.85277  -23.87443 1.000 36.52188 ? 281 VAL   A CG2 1 
ATOM   539  N N   . GLU   A 1 86  ? 11.05986  -2.45863  -23.86192 1.000 29.68248 ? 282 GLU   A N   1 
ATOM   540  C CA  . GLU   A 1 86  ? 9.90297   -1.63686  -23.51639 1.000 34.96267 ? 282 GLU   A CA  1 
ATOM   541  C C   . GLU   A 1 86  ? 8.85309   -2.44778  -22.76814 1.000 30.71399 ? 282 GLU   A C   1 
ATOM   542  O O   . GLU   A 1 86  ? 8.20356   -1.93670  -21.84893 1.000 27.78852 ? 282 GLU   A O   1 
ATOM   543  C CB  . GLU   A 1 86  ? 9.29272   -1.01251  -24.77269 1.000 35.14905 ? 282 GLU   A CB  1 
ATOM   544  C CG  . GLU   A 1 86  ? 10.27161  -0.75501  -25.90275 1.000 44.16885 ? 282 GLU   A CG  1 
ATOM   545  C CD  . GLU   A 1 86  ? 10.98245  0.58041   -25.77833 1.000 57.51285 ? 282 GLU   A CD  1 
ATOM   546  O OE1 . GLU   A 1 86  ? 10.86959  1.22477   -24.71348 1.000 58.58891 ? 282 GLU   A OE1 1 
ATOM   547  O OE2 . GLU   A 1 86  ? 11.65599  0.98619   -26.74958 1.000 60.62545 ? 282 GLU   A OE2 1 
ATOM   548  N N   . THR   A 1 87  ? 8.67197   -3.71488  -23.14869 1.000 26.98758 ? 283 THR   A N   1 
ATOM   549  C CA  . THR   A 1 87  ? 7.68422   -4.55590  -22.47901 1.000 25.79602 ? 283 THR   A CA  1 
ATOM   550  C C   . THR   A 1 87  ? 8.09107   -4.85698  -21.04263 1.000 27.98005 ? 283 THR   A C   1 
ATOM   551  O O   . THR   A 1 87  ? 7.23190   -4.95814  -20.15851 1.000 30.41587 ? 283 THR   A O   1 
ATOM   552  C CB  . THR   A 1 87  ? 7.47915   -5.85150  -23.26231 1.000 29.57018 ? 283 THR   A CB  1 
ATOM   553  O OG1 . THR   A 1 87  ? 7.48303   -5.56444  -24.66604 1.000 29.82156 ? 283 THR   A OG1 1 
ATOM   554  C CG2 . THR   A 1 87  ? 6.15623   -6.50362  -22.88341 1.000 33.11462 ? 283 THR   A CG2 1 
ATOM   555  N N   . VAL   A 1 88  ? 9.39357   -5.01033  -20.79002 1.000 26.82789 ? 284 VAL   A N   1 
ATOM   556  C CA  . VAL   A 1 88  ? 9.86152   -5.20397  -19.41997 1.000 30.72794 ? 284 VAL   A CA  1 
ATOM   557  C C   . VAL   A 1 88  ? 9.53101   -3.98128  -18.57491 1.000 28.38752 ? 284 VAL   A C   1 
ATOM   558  O O   . VAL   A 1 88  ? 9.11294   -4.10045  -17.41615 1.000 31.06038 ? 284 VAL   A O   1 
ATOM   559  C CB  . VAL   A 1 88  ? 11.37019  -5.51583  -19.40634 1.000 29.40863 ? 284 VAL   A CB  1 
ATOM   560  C CG1 . VAL   A 1 88  ? 11.93918  -5.35981  -18.00232 1.000 30.26268 ? 284 VAL   A CG1 1 
ATOM   561  C CG2 . VAL   A 1 88  ? 11.62422  -6.91765  -19.93406 1.000 29.41412 ? 284 VAL   A CG2 1 
ATOM   562  N N   . THR   A 1 89  ? 9.69904   -2.78658  -19.14626 1.000 34.62564 ? 285 THR   A N   1 
ATOM   563  C CA  . THR   A 1 89  ? 9.32214   -1.56869  -18.43696 1.000 30.91687 ? 285 THR   A CA  1 
ATOM   564  C C   . THR   A 1 89  ? 7.82392   -1.53705  -18.16301 1.000 27.36831 ? 285 THR   A C   1 
ATOM   565  O O   . THR   A 1 89  ? 7.39371   -1.17504  -17.06201 1.000 30.00075 ? 285 THR   A O   1 
ATOM   566  C CB  . THR   A 1 89  ? 9.74799   -0.33895  -19.24073 1.000 37.87614 ? 285 THR   A CB  1 
ATOM   567  O OG1 . THR   A 1 89  ? 11.16585  -0.36954  -19.44814 1.000 40.90392 ? 285 THR   A OG1 1 
ATOM   568  C CG2 . THR   A 1 89  ? 9.37701   0.93920   -18.50269 1.000 35.21671 ? 285 THR   A CG2 1 
ATOM   569  N N   . GLU   A 1 90  ? 7.01269   -1.92294  -19.15079 1.000 30.24262 ? 286 GLU   A N   1 
ATOM   570  C CA  . GLU   A 1 90  ? 5.56943   -1.97322  -18.93960 1.000 30.81441 ? 286 GLU   A CA  1 
ATOM   571  C C   . GLU   A 1 90  ? 5.19797   -3.03878  -17.91562 1.000 29.50426 ? 286 GLU   A C   1 
ATOM   572  O O   . GLU   A 1 90  ? 4.32042   -2.81741  -17.07247 1.000 29.42779 ? 286 GLU   A O   1 
ATOM   573  C CB  . GLU   A 1 90  ? 4.85255   -2.22667  -20.26505 1.000 26.57910 ? 286 GLU   A CB  1 
ATOM   574  C CG  . GLU   A 1 90  ? 5.17366   -1.20780  -21.34680 1.000 28.35225 ? 286 GLU   A CG  1 
ATOM   575  C CD  . GLU   A 1 90  ? 4.43064   -1.47738  -22.63989 1.000 37.88763 ? 286 GLU   A CD  1 
ATOM   576  O OE1 . GLU   A 1 90  ? 4.19890   -2.66330  -22.95912 1.000 35.75517 ? 286 GLU   A OE1 1 
ATOM   577  O OE2 . GLU   A 1 90  ? 4.08002   -0.50245  -23.33830 1.000 38.93359 ? 286 GLU   A OE2 1 
ATOM   578  N N   . LEU   A 1 91  ? 5.85743   -4.19990  -17.96949 1.000 29.20289 ? 287 LEU   A N   1 
ATOM   579  C CA  . LEU   A 1 91  ? 5.57752   -5.25353  -16.99921 1.000 28.65854 ? 287 LEU   A CA  1 
ATOM   580  C C   . LEU   A 1 91  ? 5.98812   -4.84218  -15.59170 1.000 27.01702 ? 287 LEU   A C   1 
ATOM   581  O O   . LEU   A 1 91  ? 5.35115   -5.25588  -14.61630 1.000 30.44748 ? 287 LEU   A O   1 
ATOM   582  C CB  . LEU   A 1 91  ? 6.28801   -6.54560  -17.40451 1.000 27.05685 ? 287 LEU   A CB  1 
ATOM   583  C CG  . LEU   A 1 91  ? 5.56221   -7.42756  -18.42384 1.000 28.28933 ? 287 LEU   A CG  1 
ATOM   584  C CD1 . LEU   A 1 91  ? 6.54031   -8.35728  -19.12412 1.000 30.05921 ? 287 LEU   A CD1 1 
ATOM   585  C CD2 . LEU   A 1 91  ? 4.45512   -8.22333  -17.74959 1.000 25.19777 ? 287 LEU   A CD2 1 
ATOM   586  N N   . THR   A 1 92  ? 7.04338   -4.03481  -15.46633 1.000 24.23958 ? 288 THR   A N   1 
ATOM   587  C CA  . THR   A 1 92  ? 7.44977   -3.54110  -14.15443 1.000 29.09736 ? 288 THR   A CA  1 
ATOM   588  C C   . THR   A 1 92  ? 6.37761   -2.63710  -13.55780 1.000 28.50405 ? 288 THR   A C   1 
ATOM   589  O O   . THR   A 1 92  ? 6.00870   -2.77775  -12.38583 1.000 34.67093 ? 288 THR   A O   1 
ATOM   590  C CB  . THR   A 1 92  ? 8.78177   -2.79728  -14.26422 1.000 29.08168 ? 288 THR   A CB  1 
ATOM   591  O OG1 . THR   A 1 92  ? 9.82036   -3.72271  -14.60721 1.000 34.51301 ? 288 THR   A OG1 1 
ATOM   592  C CG2 . THR   A 1 92  ? 9.12641   -2.12091  -12.94449 1.000 33.69911 ? 288 THR   A CG2 1 
ATOM   593  N N   . GLU   A 1 93  ? 5.86115   -1.70166  -14.35689 1.000 27.07989 ? 289 GLU   A N   1 
ATOM   594  C CA  . GLU   A 1 93  ? 4.79476   -0.82774  -13.87782 1.000 36.08768 ? 289 GLU   A CA  1 
ATOM   595  C C   . GLU   A 1 93  ? 3.51176   -1.61070  -13.62725 1.000 34.35906 ? 289 GLU   A C   1 
ATOM   596  O O   . GLU   A 1 93  ? 2.76918   -1.31071  -12.68486 1.000 31.88991 ? 289 GLU   A O   1 
ATOM   597  C CB  . GLU   A 1 93  ? 4.55186   0.29901   -14.88117 1.000 37.21607 ? 289 GLU   A CB  1 
ATOM   598  C CG  . GLU   A 1 93  ? 5.63757   1.36197   -14.89346 1.000 42.20635 ? 289 GLU   A CG  1 
ATOM   599  C CD  . GLU   A 1 93  ? 5.86503   1.97562   -13.52684 1.000 46.88149 ? 289 GLU   A CD  1 
ATOM   600  O OE1 . GLU   A 1 93  ? 4.89230   2.49058   -12.93571 1.000 52.72908 ? 289 GLU   A OE1 1 
ATOM   601  O OE2 . GLU   A 1 93  ? 7.01540   1.93910   -13.04207 1.000 50.04063 ? 289 GLU   A OE2 1 
ATOM   602  N N   . PHE   A 1 94  ? 3.23670   -2.61846  -14.46059 1.000 31.33258 ? 290 PHE   A N   1 
ATOM   603  C CA  . PHE   A 1 94  ? 2.06597   -3.46353  -14.24723 1.000 29.41803 ? 290 PHE   A CA  1 
ATOM   604  C C   . PHE   A 1 94  ? 2.15811   -4.20554  -12.92045 1.000 31.70233 ? 290 PHE   A C   1 
ATOM   605  O O   . PHE   A 1 94  ? 1.17142   -4.29495  -12.18027 1.000 29.96978 ? 290 PHE   A O   1 
ATOM   606  C CB  . PHE   A 1 94  ? 1.91547   -4.45051  -15.40633 1.000 25.09963 ? 290 PHE   A CB  1 
ATOM   607  C CG  . PHE   A 1 94  ? 0.90535   -5.53790  -15.15563 1.000 25.12248 ? 290 PHE   A CG  1 
ATOM   608  C CD1 . PHE   A 1 94  ? -0.45172  -5.28012  -15.26170 1.000 26.34271 ? 290 PHE   A CD1 1 
ATOM   609  C CD2 . PHE   A 1 94  ? 1.31433   -6.81982  -14.82084 1.000 28.85416 ? 290 PHE   A CD2 1 
ATOM   610  C CE1 . PHE   A 1 94  ? -1.38349  -6.27858  -15.03393 1.000 28.14754 ? 290 PHE   A CE1 1 
ATOM   611  C CE2 . PHE   A 1 94  ? 0.38798   -7.82412  -14.59204 1.000 27.08011 ? 290 PHE   A CE2 1 
ATOM   612  C CZ  . PHE   A 1 94  ? -0.96257  -7.55329  -14.69919 1.000 28.04595 ? 290 PHE   A CZ  1 
ATOM   613  N N   . ALA   A 1 95  ? 3.33733   -4.74581  -12.60219 1.000 30.03458 ? 291 ALA   A N   1 
ATOM   614  C CA  . ALA   A 1 95  ? 3.50878   -5.44171  -11.33201 1.000 32.69918 ? 291 ALA   A CA  1 
ATOM   615  C C   . ALA   A 1 95  ? 3.35654   -4.49422  -10.14984 1.000 36.90647 ? 291 ALA   A C   1 
ATOM   616  O O   . ALA   A 1 95  ? 2.87360   -4.90184  -9.08761  1.000 34.11698 ? 291 ALA   A O   1 
ATOM   617  C CB  . ALA   A 1 95  ? 4.87251   -6.13064  -11.28909 1.000 30.66559 ? 291 ALA   A CB  1 
ATOM   618  N N   . LYS   A 1 96  ? 3.75560   -3.22964  -10.31478 1.000 36.12019 ? 292 LYS   A N   1 
ATOM   619  C CA  . LYS   A 1 96  ? 3.62430   -2.26206  -9.23000  1.000 36.72606 ? 292 LYS   A CA  1 
ATOM   620  C C   . LYS   A 1 96  ? 2.16850   -2.03397  -8.85163  1.000 37.07272 ? 292 LYS   A C   1 
ATOM   621  O O   . LYS   A 1 96  ? 1.86617   -1.76247  -7.68386  1.000 42.21520 ? 292 LYS   A O   1 
ATOM   622  C CB  . LYS   A 1 96  ? 4.27551   -0.93691  -9.62316  1.000 37.86479 ? 292 LYS   A CB  1 
ATOM   623  C CG  . LYS   A 1 96  ? 5.76225   -0.86830  -9.34363  1.000 38.14137 ? 292 LYS   A CG  1 
ATOM   624  C CD  . LYS   A 1 96  ? 6.36062   0.40988   -9.90017  1.000 40.62983 ? 292 LYS   A CD  1 
ATOM   625  C CE  . LYS   A 1 96  ? 7.85607   0.26743   -10.10100 1.000 41.50330 ? 292 LYS   A CE  1 
ATOM   626  N NZ  . LYS   A 1 96  ? 8.48176   1.53044   -10.58324 1.000 45.03291 ? 292 LYS   A NZ  1 
ATOM   627  N N   . ALA   A 1 97  ? 1.25626   -2.13603  -9.81719  1.000 35.48934 ? 293 ALA   A N   1 
ATOM   628  C CA  . ALA   A 1 97  ? -0.15995  -1.94605  -9.54110  1.000 36.36912 ? 293 ALA   A CA  1 
ATOM   629  C C   . ALA   A 1 97  ? -0.82527  -3.18845  -8.96568  1.000 34.13343 ? 293 ALA   A C   1 
ATOM   630  O O   . ALA   A 1 97  ? -1.99040  -3.11353  -8.56178  1.000 38.26201 ? 293 ALA   A O   1 
ATOM   631  C CB  . ALA   A 1 97  ? -0.88910  -1.51118  -10.81309 1.000 39.47255 ? 293 ALA   A CB  1 
ATOM   632  N N   . ILE   A 1 98  ? -0.12679  -4.31898  -8.91957  1.000 37.28726 ? 294 ILE   A N   1 
ATOM   633  C CA  . ILE   A 1 98  ? -0.66068  -5.52825  -8.29794  1.000 36.26927 ? 294 ILE   A CA  1 
ATOM   634  C C   . ILE   A 1 98  ? -0.63033  -5.33969  -6.78598  1.000 38.28885 ? 294 ILE   A C   1 
ATOM   635  O O   . ILE   A 1 98  ? 0.44287   -5.08933  -6.21821  1.000 40.07333 ? 294 ILE   A O   1 
ATOM   636  C CB  . ILE   A 1 98  ? 0.13072   -6.77690  -8.71695  1.000 33.92222 ? 294 ILE   A CB  1 
ATOM   637  C CG1 . ILE   A 1 98  ? -0.00791  -7.02305  -10.22071 1.000 32.65587 ? 294 ILE   A CG1 1 
ATOM   638  C CG2 . ILE   A 1 98  ? -0.33898  -7.99016  -7.93090  1.000 30.60934 ? 294 ILE   A CG2 1 
ATOM   639  C CD1 . ILE   A 1 98  ? 0.84607   -8.16904  -10.73070 1.000 30.16492 ? 294 ILE   A CD1 1 
ATOM   640  N N   . PRO   A 1 99  ? -1.76801  -5.44459  -6.10040  1.000 38.98493 ? 295 PRO   A N   1 
ATOM   641  C CA  . PRO   A 1 99  ? -1.78217  -5.22152  -4.64772  1.000 37.17901 ? 295 PRO   A CA  1 
ATOM   642  C C   . PRO   A 1 99  ? -0.88287  -6.21083  -3.92053  1.000 35.19365 ? 295 PRO   A C   1 
ATOM   643  O O   . PRO   A 1 99  ? -0.98088  -7.42484  -4.11167  1.000 38.52189 ? 295 PRO   A O   1 
ATOM   644  C CB  . PRO   A 1 99  ? -3.25672  -5.41756  -4.27380  1.000 41.44480 ? 295 PRO   A CB  1 
ATOM   645  C CG  . PRO   A 1 99  ? -4.00779  -5.20054  -5.54566  1.000 39.87432 ? 295 PRO   A CG  1 
ATOM   646  C CD  . PRO   A 1 99  ? -3.11363  -5.70771  -6.63461  1.000 38.92154 ? 295 PRO   A CD  1 
ATOM   647  N N   . GLY   A 1 100 ? 0.00172   -5.67625  -3.07977  1.000 34.08605 ? 296 GLY   A N   1 
ATOM   648  C CA  . GLY   A 1 100 ? 0.93177   -6.46821  -2.31092  1.000 36.65235 ? 296 GLY   A CA  1 
ATOM   649  C C   . GLY   A 1 100 ? 2.31680   -6.58218  -2.91444  1.000 42.80562 ? 296 GLY   A C   1 
ATOM   650  O O   . GLY   A 1 100 ? 3.26845   -6.89404  -2.18839  1.000 46.37945 ? 296 GLY   A O   1 
ATOM   651  N N   . PHE   A 1 101 ? 2.45479   -6.33942  -4.22063  1.000 38.52130 ? 297 PHE   A N   1 
ATOM   652  C CA  . PHE   A 1 101 ? 3.76207   -6.45076  -4.86018  1.000 36.76747 ? 297 PHE   A CA  1 
ATOM   653  C C   . PHE   A 1 101 ? 4.72227   -5.38517  -4.34658  1.000 38.07630 ? 297 PHE   A C   1 
ATOM   654  O O   . PHE   A 1 101 ? 5.88277   -5.68314  -4.04122  1.000 35.15515 ? 297 PHE   A O   1 
ATOM   655  C CB  . PHE   A 1 101 ? 3.61165   -6.35222  -6.37868  1.000 33.22228 ? 297 PHE   A CB  1 
ATOM   656  C CG  . PHE   A 1 101 ? 4.89870   -6.55279  -7.13421  1.000 35.22288 ? 297 PHE   A CG  1 
ATOM   657  C CD1 . PHE   A 1 101 ? 5.31851   -7.82524  -7.48614  1.000 33.71165 ? 297 PHE   A CD1 1 
ATOM   658  C CD2 . PHE   A 1 101 ? 5.68424   -5.46938  -7.49770  1.000 38.01451 ? 297 PHE   A CD2 1 
ATOM   659  C CE1 . PHE   A 1 101 ? 6.49834   -8.01522  -8.18178  1.000 27.94244 ? 297 PHE   A CE1 1 
ATOM   660  C CE2 . PHE   A 1 101 ? 6.86751   -5.65226  -8.19289  1.000 33.10591 ? 297 PHE   A CE2 1 
ATOM   661  C CZ  . PHE   A 1 101 ? 7.27424   -6.92706  -8.53548  1.000 35.97999 ? 297 PHE   A CZ  1 
ATOM   662  N N   . ALA   A 1 102 ? 4.25757   -4.13750  -4.24364  1.000 43.35866 ? 298 ALA   A N   1 
ATOM   663  C CA  . ALA   A 1 102 ? 5.11491   -3.05811  -3.76864  1.000 46.77646 ? 298 ALA   A CA  1 
ATOM   664  C C   . ALA   A 1 102 ? 5.49810   -3.22092  -2.30361  1.000 43.63807 ? 298 ALA   A C   1 
ATOM   665  O O   . ALA   A 1 102 ? 6.47575   -2.60867  -1.86114  1.000 44.90451 ? 298 ALA   A O   1 
ATOM   666  C CB  . ALA   A 1 102 ? 4.42843   -1.70793  -3.98153  1.000 43.73602 ? 298 ALA   A CB  1 
ATOM   667  N N   . ASN   A 1 103 ? 4.75656   -4.02997  -1.54457  1.000 48.52160 ? 299 ASN   A N   1 
ATOM   668  C CA  . ASN   A 1 103 ? 5.08207   -4.25802  -0.14281  1.000 49.81801 ? 299 ASN   A CA  1 
ATOM   669  C C   . ASN   A 1 103 ? 6.22105   -5.25126  0.04234   1.000 50.40203 ? 299 ASN   A C   1 
ATOM   670  O O   . ASN   A 1 103 ? 6.79536   -5.31693  1.13491   1.000 47.60095 ? 299 ASN   A O   1 
ATOM   671  C CB  . ASN   A 1 103 ? 3.84450   -4.74851  0.61170   1.000 52.46303 ? 299 ASN   A CB  1 
ATOM   672  C CG  . ASN   A 1 103 ? 2.76598   -3.68823  0.71107   1.000 58.83875 ? 299 ASN   A CG  1 
ATOM   673  O OD1 . ASN   A 1 103 ? 1.58567   -3.96504  0.49803   1.000 62.73644 ? 299 ASN   A OD1 1 
ATOM   674  N ND2 . ASN   A 1 103 ? 3.16754   -2.46398  1.03520   1.000 51.63757 ? 299 ASN   A ND2 1 
ATOM   675  N N   . LEU   A 1 104 ? 6.55699   -6.02099  -0.98959  1.000 47.25878 ? 300 LEU   A N   1 
ATOM   676  C CA  . LEU   A 1 104 ? 7.65554   -6.96838  -0.89351  1.000 43.86188 ? 300 LEU   A CA  1 
ATOM   677  C C   . LEU   A 1 104 ? 8.99184   -6.23728  -0.80772  1.000 45.48072 ? 300 LEU   A C   1 
ATOM   678  O O   . LEU   A 1 104 ? 9.11161   -5.05666  -1.14800  1.000 47.95321 ? 300 LEU   A O   1 
ATOM   679  C CB  . LEU   A 1 104 ? 7.66311   -7.91151  -2.09710  1.000 47.53107 ? 300 LEU   A CB  1 
ATOM   680  C CG  . LEU   A 1 104 ? 6.35565   -8.62155  -2.44557  1.000 44.13602 ? 300 LEU   A CG  1 
ATOM   681  C CD1 . LEU   A 1 104 ? 6.44803   -9.25791  -3.82257  1.000 41.93272 ? 300 LEU   A CD1 1 
ATOM   682  C CD2 . LEU   A 1 104 ? 6.03816   -9.66827  -1.39730  1.000 48.07587 ? 300 LEU   A CD2 1 
ATOM   683  N N   . ASP   A 1 105 ? 10.00596  -6.95988  -0.33853  1.000 46.05161 ? 301 ASP   A N   1 
ATOM   684  C CA  . ASP   A 1 105 ? 11.35815  -6.42426  -0.34175  1.000 46.48295 ? 301 ASP   A CA  1 
ATOM   685  C C   . ASP   A 1 105 ? 11.81699  -6.18015  -1.77345  1.000 45.74485 ? 301 ASP   A C   1 
ATOM   686  O O   . ASP   A 1 105 ? 11.37289  -6.84404  -2.71411  1.000 41.88164 ? 301 ASP   A O   1 
ATOM   687  C CB  . ASP   A 1 105 ? 12.31748  -7.38028  0.36772   1.000 43.16805 ? 301 ASP   A CB  1 
ATOM   688  C CG  . ASP   A 1 105 ? 12.13416  -7.37758  1.87341   1.000 63.82142 ? 301 ASP   A CG  1 
ATOM   689  O OD1 . ASP   A 1 105 ? 11.82202  -8.44690  2.43894   1.000 67.20962 ? 301 ASP   A OD1 1 
ATOM   690  O OD2 . ASP   A 1 105 ? 12.29919  -6.30432  2.49160   1.000 63.11537 ? 301 ASP   A OD2 1 
ATOM   691  N N   . LEU   A 1 106 ? 12.71394  -5.20535  -1.93256  1.000 48.68833 ? 302 LEU   A N   1 
ATOM   692  C CA  . LEU   A 1 106 ? 13.15686  -4.81759  -3.26781  1.000 42.91806 ? 302 LEU   A CA  1 
ATOM   693  C C   . LEU   A 1 106 ? 13.84234  -5.97474  -3.98537  1.000 44.95132 ? 302 LEU   A C   1 
ATOM   694  O O   . LEU   A 1 106 ? 13.70124  -6.12892  -5.20433  1.000 40.02821 ? 302 LEU   A O   1 
ATOM   695  C CB  . LEU   A 1 106 ? 14.08347  -3.60596  -3.17256  1.000 47.32858 ? 302 LEU   A CB  1 
ATOM   696  C CG  . LEU   A 1 106 ? 14.62690  -3.02355  -4.47571  1.000 47.15975 ? 302 LEU   A CG  1 
ATOM   697  C CD1 . LEU   A 1 106 ? 13.49523  -2.46623  -5.31962  1.000 46.91178 ? 302 LEU   A CD1 1 
ATOM   698  C CD2 . LEU   A 1 106 ? 15.64063  -1.93727  -4.16548  1.000 51.45765 ? 302 LEU   A CD2 1 
ATOM   699  N N   . ASN   A 1 107 ? 14.57742  -6.80785  -3.24465  1.000 42.76955 ? 303 ASN   A N   1 
ATOM   700  C CA  . ASN   A 1 107 ? 15.23391  -7.95700  -3.86063  1.000 42.79440 ? 303 ASN   A CA  1 
ATOM   701  C C   . ASN   A 1 107 ? 14.21516  -8.97840  -4.35354  1.000 40.16084 ? 303 ASN   A C   1 
ATOM   702  O O   . ASN   A 1 107 ? 14.41472  -9.60757  -5.39951  1.000 36.70487 ? 303 ASN   A O   1 
ATOM   703  C CB  . ASN   A 1 107 ? 16.20498  -8.60103  -2.87063  1.000 45.40708 ? 303 ASN   A CB  1 
ATOM   704  C CG  . ASN   A 1 107 ? 17.47896  -7.79455  -2.69312  1.000 55.43299 ? 303 ASN   A CG  1 
ATOM   705  O OD1 . ASN   A 1 107 ? 17.77311  -6.89425  -3.48007  1.000 46.76518 ? 303 ASN   A OD1 1 
ATOM   706  N ND2 . ASN   A 1 107 ? 18.24221  -8.11502  -1.65411  1.000 46.23438 ? 303 ASN   A ND2 1 
ATOM   707  N N   . ASP   A 1 108 ? 13.11742  -9.15753  -3.61485  1.000 40.78662 ? 304 ASP   A N   1 
ATOM   708  C CA  . ASP   A 1 108 ? 12.08636  -10.09661 -4.04474  1.000 36.44195 ? 304 ASP   A CA  1 
ATOM   709  C C   . ASP   A 1 108 ? 11.36362  -9.59126  -5.28730  1.000 32.99628 ? 304 ASP   A C   1 
ATOM   710  O O   . ASP   A 1 108 ? 10.98028  -10.38542 -6.15422  1.000 34.03401 ? 304 ASP   A O   1 
ATOM   711  C CB  . ASP   A 1 108 ? 11.09686  -10.34789 -2.90681  1.000 31.88500 ? 304 ASP   A CB  1 
ATOM   712  C CG  . ASP   A 1 108 ? 11.48882  -11.53343 -2.04438  1.000 41.56941 ? 304 ASP   A CG  1 
ATOM   713  O OD1 . ASP   A 1 108 ? 12.43467  -12.25793 -2.42074  1.000 35.55969 ? 304 ASP   A OD1 1 
ATOM   714  O OD2 . ASP   A 1 108 ? 10.85219  -11.74034 -0.98885  1.000 43.02161 ? 304 ASP   A OD2 1 
ATOM   715  N N   . GLN   A 1 109 ? 11.16874  -8.27386  -5.39231  1.000 36.40218 ? 305 GLN   A N   1 
ATOM   716  C CA  . GLN   A 1 109 ? 10.55617  -7.71135  -6.59190  1.000 36.89363 ? 305 GLN   A CA  1 
ATOM   717  C C   . GLN   A 1 109 ? 11.43571  -7.93835  -7.81503  1.000 37.33683 ? 305 GLN   A C   1 
ATOM   718  O O   . GLN   A 1 109 ? 10.92959  -8.17896  -8.91770  1.000 32.60843 ? 305 GLN   A O   1 
ATOM   719  C CB  . GLN   A 1 109 ? 10.28605  -6.21921  -6.39478  1.000 35.19498 ? 305 GLN   A CB  1 
ATOM   720  C CG  . GLN   A 1 109 ? 9.33289   -5.90168  -5.25277  1.000 40.88323 ? 305 GLN   A CG  1 
ATOM   721  C CD  . GLN   A 1 109 ? 9.14099   -4.40972  -5.04934  1.000 42.01380 ? 305 GLN   A CD  1 
ATOM   722  O OE1 . GLN   A 1 109 ? 9.09455   -3.64142  -6.00970  1.000 42.56318 ? 305 GLN   A OE1 1 
ATOM   723  N NE2 . GLN   A 1 109 ? 9.02733   -3.99305  -3.79369  1.000 43.74232 ? 305 GLN   A NE2 1 
ATOM   724  N N   . VAL   A 1 110 ? 12.75743  -7.86613  -7.63820  1.000 41.34444 ? 306 VAL   A N   1 
ATOM   725  C CA  . VAL   A 1 110 ? 13.67610  -8.12276  -8.74352  1.000 36.66030 ? 306 VAL   A CA  1 
ATOM   726  C C   . VAL   A 1 110 ? 13.60464  -9.58330  -9.17108  1.000 32.99220 ? 306 VAL   A C   1 
ATOM   727  O O   . VAL   A 1 110 ? 13.60306  -9.89475  -10.36838 1.000 33.41296 ? 306 VAL   A O   1 
ATOM   728  C CB  . VAL   A 1 110 ? 15.10940  -7.72022  -8.34951  1.000 38.88075 ? 306 VAL   A CB  1 
ATOM   729  C CG1 . VAL   A 1 110 ? 16.09631  -8.12532  -9.43513  1.000 37.54592 ? 306 VAL   A CG1 1 
ATOM   730  C CG2 . VAL   A 1 110 ? 15.18746  -6.22743  -8.08433  1.000 38.14944 ? 306 VAL   A CG2 1 
ATOM   731  N N   . THR   A 1 111 ? 13.54095  -10.50083 -8.20299  1.000 34.56624 ? 307 THR   A N   1 
ATOM   732  C CA  . THR   A 1 111 ? 13.50585  -11.92308 -8.53000  1.000 37.03937 ? 307 THR   A CA  1 
ATOM   733  C C   . THR   A 1 111 ? 12.22937  -12.29147 -9.27669  1.000 33.01527 ? 307 THR   A C   1 
ATOM   734  O O   . THR   A 1 111 ? 12.27090  -13.06022 -10.24538 1.000 30.30852 ? 307 THR   A O   1 
ATOM   735  C CB  . THR   A 1 111 ? 13.63802  -12.75901 -7.25685  1.000 38.26092 ? 307 THR   A CB  1 
ATOM   736  O OG1 . THR   A 1 111 ? 14.86750  -12.43575 -6.59462  1.000 42.94214 ? 307 THR   A OG1 1 
ATOM   737  C CG2 . THR   A 1 111 ? 13.62164  -14.24320 -7.59083  1.000 38.37117 ? 307 THR   A CG2 1 
ATOM   738  N N   . LEU   A 1 112 ? 11.08685  -11.75172 -8.84296  1.000 29.97431 ? 308 LEU   A N   1 
ATOM   739  C CA  . LEU   A 1 112 ? 9.82345   -12.06449 -9.50394  1.000 31.96267 ? 308 LEU   A CA  1 
ATOM   740  C C   . LEU   A 1 112 ? 9.82406   -11.58635 -10.94958 1.000 30.95793 ? 308 LEU   A C   1 
ATOM   741  O O   . LEU   A 1 112 ? 9.39991   -12.31576 -11.85298 1.000 29.42357 ? 308 LEU   A O   1 
ATOM   742  C CB  . LEU   A 1 112 ? 8.65929   -11.44089 -8.73511  1.000 26.96827 ? 308 LEU   A CB  1 
ATOM   743  C CG  . LEU   A 1 112 ? 8.33089   -12.06825 -7.37983  1.000 29.60555 ? 308 LEU   A CG  1 
ATOM   744  C CD1 . LEU   A 1 112 ? 7.06533   -11.45603 -6.79910  1.000 30.50257 ? 308 LEU   A CD1 1 
ATOM   745  C CD2 . LEU   A 1 112 ? 8.19179   -13.57630 -7.50755  1.000 31.91496 ? 308 LEU   A CD2 1 
ATOM   746  N N   . LEU   A 1 113 ? 10.30165  -10.36410 -11.18924 1.000 29.24735 ? 309 LEU   A N   1 
ATOM   747  C CA  . LEU   A 1 113 ? 10.33687  -9.84376  -12.55134 1.000 30.25744 ? 309 LEU   A CA  1 
ATOM   748  C C   . LEU   A 1 113 ? 11.36542  -10.58150 -13.39973 1.000 27.28535 ? 309 LEU   A C   1 
ATOM   749  O O   . LEU   A 1 113 ? 11.11475  -10.86731 -14.57571 1.000 22.57270 ? 309 LEU   A O   1 
ATOM   750  C CB  . LEU   A 1 113 ? 10.63219  -8.34438  -12.53203 1.000 28.49751 ? 309 LEU   A CB  1 
ATOM   751  C CG  . LEU   A 1 113 ? 9.44529   -7.42006  -12.25328 1.000 30.88002 ? 309 LEU   A CG  1 
ATOM   752  C CD1 . LEU   A 1 113 ? 9.91151   -5.98118  -12.12025 1.000 37.86032 ? 309 LEU   A CD1 1 
ATOM   753  C CD2 . LEU   A 1 113 ? 8.39267   -7.54590  -13.34576 1.000 30.30850 ? 309 LEU   A CD2 1 
ATOM   754  N N   . LYS   A 1 114 ? 12.51915  -10.91366 -12.81403 1.000 32.97332 ? 310 LYS   A N   1 
ATOM   755  C CA  . LYS   A 1 114 ? 13.60665  -11.51756 -13.58009 1.000 30.14426 ? 310 LYS   A CA  1 
ATOM   756  C C   . LYS   A 1 114 ? 13.17038  -12.82249 -14.23748 1.000 31.22272 ? 310 LYS   A C   1 
ATOM   757  O O   . LYS   A 1 114 ? 13.44517  -13.05829 -15.41989 1.000 29.40014 ? 310 LYS   A O   1 
ATOM   758  C CB  . LYS   A 1 114 ? 14.81489  -11.74848 -12.67180 1.000 32.48458 ? 310 LYS   A CB  1 
ATOM   759  C CG  . LYS   A 1 114 ? 15.91857  -12.57336 -13.30696 1.000 32.37333 ? 310 LYS   A CG  1 
ATOM   760  C CD  . LYS   A 1 114 ? 17.05481  -12.81350 -12.32868 1.000 32.93361 ? 310 LYS   A CD  1 
ATOM   761  C CE  . LYS   A 1 114 ? 18.20938  -13.53309 -13.00146 1.000 36.33703 ? 310 LYS   A CE  1 
ATOM   762  N NZ  . LYS   A 1 114 ? 18.95093  -12.63338 -13.92923 1.000 35.66394 ? 310 LYS   A NZ  1 
ATOM   763  N N   . TYR   A 1 115 ? 12.48418  -13.68193 -13.48807 1.000 30.07464 ? 311 TYR   A N   1 
ATOM   764  C CA  . TYR   A 1 115 ? 12.04953  -14.97007 -14.00954 1.000 31.37277 ? 311 TYR   A CA  1 
ATOM   765  C C   . TYR   A 1 115 ? 10.64782  -14.93642 -14.60295 1.000 32.37475 ? 311 TYR   A C   1 
ATOM   766  O O   . TYR   A 1 115 ? 10.22247  -15.93122 -15.19980 1.000 36.05980 ? 311 TYR   A O   1 
ATOM   767  C CB  . TYR   A 1 115 ? 12.10340  -16.03150 -12.90550 1.000 32.80265 ? 311 TYR   A CB  1 
ATOM   768  C CG  . TYR   A 1 115 ? 13.50259  -16.37380 -12.44889 1.000 37.41929 ? 311 TYR   A CG  1 
ATOM   769  C CD1 . TYR   A 1 115 ? 14.21187  -17.40799 -13.04312 1.000 40.57338 ? 311 TYR   A CD1 1 
ATOM   770  C CD2 . TYR   A 1 115 ? 14.11246  -15.66613 -11.42093 1.000 32.50177 ? 311 TYR   A CD2 1 
ATOM   771  C CE1 . TYR   A 1 115 ? 15.48921  -17.72607 -12.63068 1.000 41.52267 ? 311 TYR   A CE1 1 
ATOM   772  C CE2 . TYR   A 1 115 ? 15.39107  -15.97780 -11.00076 1.000 37.64687 ? 311 TYR   A CE2 1 
ATOM   773  C CZ  . TYR   A 1 115 ? 16.07431  -17.00883 -11.61027 1.000 37.93167 ? 311 TYR   A CZ  1 
ATOM   774  O OH  . TYR   A 1 115 ? 17.34756  -17.32596 -11.19954 1.000 42.21217 ? 311 TYR   A OH  1 
ATOM   775  N N   . GLY   A 1 116 ? 9.92720   -13.82720 -14.46478 1.000 31.37377 ? 312 GLY   A N   1 
ATOM   776  C CA  . GLY   A 1 116 ? 8.54396   -13.78153 -14.89279 1.000 29.14437 ? 312 GLY   A CA  1 
ATOM   777  C C   . GLY   A 1 116 ? 8.26763   -13.02095 -16.17463 1.000 26.34039 ? 312 GLY   A C   1 
ATOM   778  O O   . GLY   A 1 116 ? 7.27361   -13.30573 -16.84961 1.000 25.02107 ? 312 GLY   A O   1 
ATOM   779  N N   . VAL   A 1 117 ? 9.12884   -12.06137 -16.53157 1.000 26.11134 ? 313 VAL   A N   1 
ATOM   780  C CA  . VAL   A 1 117 ? 8.81392   -11.16845 -17.64782 1.000 26.64733 ? 313 VAL   A CA  1 
ATOM   781  C C   . VAL   A 1 117 ? 8.70989   -11.94390 -18.95562 1.000 24.64104 ? 313 VAL   A C   1 
ATOM   782  O O   . VAL   A 1 117 ? 7.80389   -11.70418 -19.76144 1.000 26.48800 ? 313 VAL   A O   1 
ATOM   783  C CB  . VAL   A 1 117 ? 9.84647   -10.02798 -17.75281 1.000 28.21886 ? 313 VAL   A CB  1 
ATOM   784  C CG1 . VAL   A 1 117 ? 9.59531   -8.97644  -16.67820 1.000 30.11799 ? 313 VAL   A CG1 1 
ATOM   785  C CG2 . VAL   A 1 117 ? 11.26883  -10.56539 -17.68344 1.000 29.35489 ? 313 VAL   A CG2 1 
ATOM   786  N N   . TYR   A 1 118 ? 9.62334   -12.88750 -19.19028 1.000 24.38552 ? 314 TYR   A N   1 
ATOM   787  C CA  . TYR   A 1 118 ? 9.62859   -13.56736 -20.48014 1.000 24.80372 ? 314 TYR   A CA  1 
ATOM   788  C C   . TYR   A 1 118 ? 8.53270   -14.61950 -20.58424 1.000 27.45639 ? 314 TYR   A C   1 
ATOM   789  O O   . TYR   A 1 118 ? 8.06758   -14.91041 -21.69144 1.000 31.01068 ? 314 TYR   A O   1 
ATOM   790  C CB  . TYR   A 1 118 ? 11.00246  -14.17955 -20.74773 1.000 30.67743 ? 314 TYR   A CB  1 
ATOM   791  C CG  . TYR   A 1 118 ? 11.93374  -13.19864 -21.41669 1.000 31.82408 ? 314 TYR   A CG  1 
ATOM   792  C CD1 . TYR   A 1 118 ? 11.72033  -12.79843 -22.73001 1.000 33.32196 ? 314 TYR   A CD1 1 
ATOM   793  C CD2 . TYR   A 1 118 ? 13.00388  -12.64489 -20.72769 1.000 30.43573 ? 314 TYR   A CD2 1 
ATOM   794  C CE1 . TYR   A 1 118 ? 12.55909  -11.89032 -23.34485 1.000 28.10601 ? 314 TYR   A CE1 1 
ATOM   795  C CE2 . TYR   A 1 118 ? 13.84879  -11.73497 -21.33427 1.000 31.70109 ? 314 TYR   A CE2 1 
ATOM   796  C CZ  . TYR   A 1 118 ? 13.62116  -11.36088 -22.64155 1.000 29.29622 ? 314 TYR   A CZ  1 
ATOM   797  O OH  . TYR   A 1 118 ? 14.46076  -10.45684 -23.24932 1.000 32.99862 ? 314 TYR   A OH  1 
ATOM   798  N N   . GLU   A 1 119 ? 8.10271   -15.19439 -19.46017 1.000 23.55079 ? 315 GLU   A N   1 
ATOM   799  C CA  . GLU   A 1 119 ? 6.90110   -16.02117 -19.48863 1.000 26.40192 ? 315 GLU   A CA  1 
ATOM   800  C C   . GLU   A 1 119 ? 5.67867   -15.18284 -19.84144 1.000 25.67058 ? 315 GLU   A C   1 
ATOM   801  O O   . GLU   A 1 119 ? 4.82312   -15.61625 -20.62121 1.000 24.96360 ? 315 GLU   A O   1 
ATOM   802  C CB  . GLU   A 1 119 ? 6.70828   -16.72150 -18.14371 1.000 27.65716 ? 315 GLU   A CB  1 
ATOM   803  C CG  . GLU   A 1 119 ? 7.76873   -17.76365 -17.82745 1.000 29.92392 ? 315 GLU   A CG  1 
ATOM   804  C CD  . GLU   A 1 119 ? 7.52012   -18.46652 -16.50667 1.000 35.52317 ? 315 GLU   A CD  1 
ATOM   805  O OE1 . GLU   A 1 119 ? 8.40428   -19.22700 -16.05879 1.000 35.32088 ? 315 GLU   A OE1 1 
ATOM   806  O OE2 . GLU   A 1 119 ? 6.44060   -18.25793 -15.91502 1.000 31.88879 ? 315 GLU   A OE2 1 
ATOM   807  N N   . ALA   A 1 120 ? 5.59193   -13.96776 -19.29428 1.000 23.45932 ? 316 ALA   A N   1 
ATOM   808  C CA  . ALA   A 1 120 ? 4.48358   -13.08199 -19.63248 1.000 24.58359 ? 316 ALA   A CA  1 
ATOM   809  C C   . ALA   A 1 120 ? 4.60538   -12.56515 -21.06028 1.000 27.83283 ? 316 ALA   A C   1 
ATOM   810  O O   . ALA   A 1 120 ? 3.59464   -12.38628 -21.75072 1.000 22.89389 ? 316 ALA   A O   1 
ATOM   811  C CB  . ALA   A 1 120 ? 4.42553   -11.91705 -18.64545 1.000 24.47496 ? 316 ALA   A CB  1 
ATOM   812  N N   . ILE   A 1 121 ? 5.83504   -12.32399 -21.51978 1.000 23.74100 ? 317 ILE   A N   1 
ATOM   813  C CA  . ILE   A 1 121 ? 6.04257   -11.77927 -22.85924 1.000 25.31739 ? 317 ILE   A CA  1 
ATOM   814  C C   . ILE   A 1 121 ? 5.59472   -12.77997 -23.91868 1.000 27.80726 ? 317 ILE   A C   1 
ATOM   815  O O   . ILE   A 1 121 ? 4.89191   -12.42670 -24.87305 1.000 21.95539 ? 317 ILE   A O   1 
ATOM   816  C CB  . ILE   A 1 121 ? 7.51634   -11.37257 -23.04663 1.000 27.46763 ? 317 ILE   A CB  1 
ATOM   817  C CG1 . ILE   A 1 121 ? 7.76467   -9.98403  -22.45383 1.000 28.28926 ? 317 ILE   A CG1 1 
ATOM   818  C CG2 . ILE   A 1 121 ? 7.90990   -11.40558 -24.51802 1.000 29.76500 ? 317 ILE   A CG2 1 
ATOM   819  C CD1 . ILE   A 1 121 ? 9.23014   -9.59390  -22.39246 1.000 29.42064 ? 317 ILE   A CD1 1 
ATOM   820  N N   . PHE   A 1 122 ? 5.98617   -14.04669 -23.76440 1.000 24.67162 ? 318 PHE   A N   1 
ATOM   821  C CA  . PHE   A 1 122 ? 5.60664   -15.04939 -24.75360 1.000 26.30224 ? 318 PHE   A CA  1 
ATOM   822  C C   . PHE   A 1 122 ? 4.13510   -15.42293 -24.63877 1.000 27.19236 ? 318 PHE   A C   1 
ATOM   823  O O   . PHE   A 1 122 ? 3.52435   -15.83682 -25.63041 1.000 26.37893 ? 318 PHE   A O   1 
ATOM   824  C CB  . PHE   A 1 122 ? 6.49895   -16.28187 -24.61792 1.000 29.92895 ? 318 PHE   A CB  1 
ATOM   825  C CG  . PHE   A 1 122 ? 7.93890   -16.01591 -24.95324 1.000 29.32202 ? 318 PHE   A CG  1 
ATOM   826  C CD1 . PHE   A 1 122 ? 8.27179   -15.20056 -26.02411 1.000 25.65823 ? 318 PHE   A CD1 1 
ATOM   827  C CD2 . PHE   A 1 122 ? 8.95703   -16.56483 -24.19327 1.000 26.53637 ? 318 PHE   A CD2 1 
ATOM   828  C CE1 . PHE   A 1 122 ? 9.59574   -14.94468 -26.33535 1.000 30.88981 ? 318 PHE   A CE1 1 
ATOM   829  C CE2 . PHE   A 1 122 ? 10.28264  -16.31315 -24.49918 1.000 32.23107 ? 318 PHE   A CE2 1 
ATOM   830  C CZ  . PHE   A 1 122 ? 10.60234  -15.50243 -25.57036 1.000 33.12575 ? 318 PHE   A CZ  1 
ATOM   831  N N   . ALA   A 1 123 ? 3.54655   -15.28145 -23.45004 1.000 21.91788 ? 319 ALA   A N   1 
ATOM   832  C CA  . ALA   A 1 123 ? 2.10021   -15.43272 -23.33340 1.000 25.74634 ? 319 ALA   A CA  1 
ATOM   833  C C   . ALA   A 1 123 ? 1.38247   -14.29436 -24.04733 1.000 19.95628 ? 319 ALA   A C   1 
ATOM   834  O O   . ALA   A 1 123 ? 0.44070   -14.52247 -24.81550 1.000 28.93998 ? 319 ALA   A O   1 
ATOM   835  C CB  . ALA   A 1 123 ? 1.69136   -15.49425 -21.86137 1.000 26.57053 ? 319 ALA   A CB  1 
ATOM   836  N N   . MET   A 1 124 ? 1.82845   -13.05760 -23.81463 1.000 20.79767 ? 320 MET   A N   1 
ATOM   837  C CA  . MET   A 1 124 ? 1.24204   -11.90065 -24.47859 1.000 25.44696 ? 320 MET   A CA  1 
ATOM   838  C C   . MET   A 1 124 ? 1.57088   -11.86300 -25.96503 1.000 30.08733 ? 320 MET   A C   1 
ATOM   839  O O   . MET   A 1 124 ? 0.81477   -11.26625 -26.73906 1.000 26.24900 ? 320 MET   A O   1 
ATOM   840  C CB  . MET   A 1 124 ? 1.72452   -10.61792 -23.80031 1.000 27.46142 ? 320 MET   A CB  1 
ATOM   841  C CG  . MET   A 1 124 ? 1.06247   -10.34465 -22.45878 1.000 28.93638 ? 320 MET   A CG  1 
ATOM   842  S SD  . MET   A 1 124 ? 1.45857   -8.71267  -21.80171 1.000 31.74757 ? 320 MET   A SD  1 
ATOM   843  C CE  . MET   A 1 124 ? 3.21354   -8.88858  -21.49381 1.000 33.86367 ? 320 MET   A CE  1 
ATOM   844  N N   . LEU   A 1 125 ? 2.67963   -12.48575 -26.37673 1.000 24.90686 ? 321 LEU   A N   1 
ATOM   845  C CA  . LEU   A 1 125 ? 3.01562   -12.55820 -27.79523 1.000 23.70873 ? 321 LEU   A CA  1 
ATOM   846  C C   . LEU   A 1 125 ? 1.92999   -13.26784 -28.59311 1.000 28.15931 ? 321 LEU   A C   1 
ATOM   847  O O   . LEU   A 1 125 ? 1.70351   -12.93558 -29.76231 1.000 23.48495 ? 321 LEU   A O   1 
ATOM   848  C CB  . LEU   A 1 125 ? 4.36282   -13.26315 -27.97480 1.000 25.72370 ? 321 LEU   A CB  1 
ATOM   849  C CG  . LEU   A 1 125 ? 4.92072   -13.42508 -29.39146 1.000 29.51763 ? 321 LEU   A CG  1 
ATOM   850  C CD1 . LEU   A 1 125 ? 5.02671   -12.07921 -30.09402 1.000 27.26082 ? 321 LEU   A CD1 1 
ATOM   851  C CD2 . LEU   A 1 125 ? 6.27815   -14.11359 -29.34662 1.000 25.34547 ? 321 LEU   A CD2 1 
ATOM   852  N N   . SER   A 1 126 ? 1.23799   -14.23168 -27.97622 1.000 23.48284 ? 322 SER   A N   1 
ATOM   853  C CA  . SER   A 1 126 ? 0.18147   -14.95572 -28.67673 1.000 28.89300 ? 322 SER   A CA  1 
ATOM   854  C C   . SER   A 1 126 ? -0.93206  -14.02640 -29.14296 1.000 31.75016 ? 322 SER   A C   1 
ATOM   855  O O   . SER   A 1 126 ? -1.62442  -14.33178 -30.12087 1.000 28.56015 ? 322 SER   A O   1 
ATOM   856  C CB  . SER   A 1 126 ? -0.39191  -16.05005 -27.77513 1.000 28.75721 ? 322 SER   A CB  1 
ATOM   857  O OG  . SER   A 1 126 ? 0.63945   -16.83392 -27.20066 1.000 29.50767 ? 322 SER   A OG  1 
ATOM   858  N N   . SER   A 1 127 ? -1.11661  -12.89075 -28.46446 1.000 26.78604 ? 323 SER   A N   1 
ATOM   859  C CA  . SER   A 1 127 ? -2.20140  -11.98087 -28.81682 1.000 26.43003 ? 323 SER   A CA  1 
ATOM   860  C C   . SER   A 1 127 ? -1.96677  -11.30820 -30.16310 1.000 31.59968 ? 323 SER   A C   1 
ATOM   861  O O   . SER   A 1 127 ? -2.92808  -10.89861 -30.82385 1.000 27.58438 ? 323 SER   A O   1 
ATOM   862  C CB  . SER   A 1 127 ? -2.37479  -10.92494 -27.72473 1.000 28.20966 ? 323 SER   A CB  1 
ATOM   863  O OG  . SER   A 1 127 ? -2.75060  -11.51938 -26.49462 1.000 27.80539 ? 323 SER   A OG  1 
ATOM   864  N N   . VAL   A 1 128 ? -0.70853  -11.17754 -30.58362 1.000 24.75071 ? 324 VAL   A N   1 
ATOM   865  C CA  . VAL   A 1 128 ? -0.38181  -10.54029 -31.85291 1.000 30.42639 ? 324 VAL   A CA  1 
ATOM   866  C C   . VAL   A 1 128 ? 0.00764   -11.56010 -32.91765 1.000 31.41751 ? 324 VAL   A C   1 
ATOM   867  O O   . VAL   A 1 128 ? 0.46309   -11.17690 -33.99874 1.000 33.87432 ? 324 VAL   A O   1 
ATOM   868  C CB  . VAL   A 1 128 ? 0.72365   -9.48620  -31.67581 1.000 26.43113 ? 324 VAL   A CB  1 
ATOM   869  C CG1 . VAL   A 1 128 ? 0.35924   -8.51969  -30.56015 1.000 30.15823 ? 324 VAL   A CG1 1 
ATOM   870  C CG2 . VAL   A 1 128 ? 2.06433   -10.15448 -31.39441 1.000 24.41792 ? 324 VAL   A CG2 1 
ATOM   871  N N   . MET   A 1 129 ? -0.16778  -12.84929 -32.64181 1.000 29.25464 ? 325 MET   A N   1 
ATOM   872  C CA  . MET   A 1 129 ? 0.19844   -13.91051 -33.56788 1.000 29.48445 ? 325 MET   A CA  1 
ATOM   873  C C   . MET   A 1 129 ? -1.04352  -14.56131 -34.16033 1.000 35.39612 ? 325 MET   A C   1 
ATOM   874  O O   . MET   A 1 129 ? -2.06272  -14.71699 -33.48009 1.000 29.04783 ? 325 MET   A O   1 
ATOM   875  C CB  . MET   A 1 129 ? 1.04345   -14.98530 -32.87640 1.000 32.05761 ? 325 MET   A CB  1 
ATOM   876  C CG  . MET   A 1 129 ? 2.51876   -14.66158 -32.75560 1.000 32.50069 ? 325 MET   A CG  1 
ATOM   877  S SD  . MET   A 1 129 ? 3.39670   -15.90920 -31.79515 1.000 31.40338 ? 325 MET   A SD  1 
ATOM   878  C CE  . MET   A 1 129 ? 5.06030   -15.71140 -32.42859 1.000 30.71664 ? 325 MET   A CE  1 
ATOM   879  N N   . ASN   A 1 130 ? -0.95104  -14.93237 -35.43628 1.000 34.60453 ? 326 ASN   A N   1 
ATOM   880  C CA  . ASN   A 1 130 ? -1.89487  -15.86976 -36.03006 1.000 35.93664 ? 326 ASN   A CA  1 
ATOM   881  C C   . ASN   A 1 130 ? -1.10357  -16.98910 -36.69319 1.000 37.94015 ? 326 ASN   A C   1 
ATOM   882  O O   . ASN   A 1 130 ? 0.11548   -17.07574 -36.51474 1.000 35.39183 ? 326 ASN   A O   1 
ATOM   883  C CB  . ASN   A 1 130 ? -2.82804  -15.17657 -37.02962 1.000 36.90946 ? 326 ASN   A CB  1 
ATOM   884  C CG  . ASN   A 1 130 ? -2.08229  -14.37733 -38.08597 1.000 38.10768 ? 326 ASN   A CG  1 
ATOM   885  O OD1 . ASN   A 1 130 ? -0.92392  -14.65280 -38.39829 1.000 40.98775 ? 326 ASN   A OD1 1 
ATOM   886  N ND2 . ASN   A 1 130 ? -2.75539  -13.37999 -38.64813 1.000 40.71845 ? 326 ASN   A ND2 1 
ATOM   887  N N   . LYS   A 1 131 ? -1.77534  -17.84386 -37.46528 1.000 36.38376 ? 327 LYS   A N   1 
ATOM   888  C CA  . LYS   A 1 131 ? -1.08035  -18.95292 -38.10837 1.000 38.83260 ? 327 LYS   A CA  1 
ATOM   889  C C   . LYS   A 1 131 ? -0.11242  -18.49142 -39.19167 1.000 37.20815 ? 327 LYS   A C   1 
ATOM   890  O O   . LYS   A 1 131 ? 0.76760   -19.26452 -39.58553 1.000 36.50272 ? 327 LYS   A O   1 
ATOM   891  C CB  . LYS   A 1 131 ? -2.09294  -19.93275 -38.70305 1.000 36.51327 ? 327 LYS   A CB  1 
ATOM   892  C CG  . LYS   A 1 131 ? -3.06051  -19.30102 -39.69359 1.000 36.49755 ? 327 LYS   A CG  1 
ATOM   893  C CD  . LYS   A 1 131 ? -3.94735  -20.34963 -40.34971 1.000 45.49719 ? 327 LYS   A CD  1 
ATOM   894  C CE  . LYS   A 1 131 ? -3.22153  -21.06563 -41.47823 1.000 52.20901 ? 327 LYS   A CE  1 
ATOM   895  N NZ  . LYS   A 1 131 ? -3.30394  -20.31048 -42.75916 1.000 48.42890 ? 327 LYS   A NZ  1 
ATOM   896  N N   . ASP   A 1 132 ? -0.24239  -17.25338 -39.67275 1.000 35.43850 ? 328 ASP   A N   1 
ATOM   897  C CA  . ASP   A 1 132 ? 0.54026   -16.78037 -40.80533 1.000 36.38084 ? 328 ASP   A CA  1 
ATOM   898  C C   . ASP   A 1 132 ? 1.62828   -15.77899 -40.43974 1.000 43.12114 ? 328 ASP   A C   1 
ATOM   899  O O   . ASP   A 1 132 ? 2.49244   -15.50377 -41.27987 1.000 39.36690 ? 328 ASP   A O   1 
ATOM   900  C CB  . ASP   A 1 132 ? -0.38542  -16.15483 -41.85957 1.000 41.05379 ? 328 ASP   A CB  1 
ATOM   901  C CG  . ASP   A 1 132 ? -1.40634  -17.14157 -42.39641 1.000 47.45612 ? 328 ASP   A CG  1 
ATOM   902  O OD1 . ASP   A 1 132 ? -1.10476  -18.35353 -42.42653 1.000 48.75047 ? 328 ASP   A OD1 1 
ATOM   903  O OD2 . ASP   A 1 132 ? -2.51058  -16.70685 -42.78587 1.000 50.13532 ? 328 ASP   A OD2 1 
ATOM   904  N N   . GLY   A 1 133 ? 1.61842   -15.22797 -39.23160 1.000 33.65959 ? 329 GLY   A N   1 
ATOM   905  C CA  . GLY   A 1 133 ? 2.64610   -14.27978 -38.85417 1.000 34.08758 ? 329 GLY   A CA  1 
ATOM   906  C C   . GLY   A 1 133 ? 2.28252   -13.55555 -37.57338 1.000 36.84244 ? 329 GLY   A C   1 
ATOM   907  O O   . GLY   A 1 133 ? 1.35960   -13.94612 -36.85376 1.000 31.24153 ? 329 GLY   A O   1 
ATOM   908  N N   . MET   A 1 134 ? 3.03257   -12.48663 -37.30649 1.000 34.21164 ? 330 MET   A N   1 
ATOM   909  C CA  . MET   A 1 134 ? 2.86560   -11.70971 -36.08750 1.000 33.80161 ? 330 MET   A CA  1 
ATOM   910  C C   . MET   A 1 134 ? 3.01433   -10.22607 -36.39493 1.000 40.22249 ? 330 MET   A C   1 
ATOM   911  O O   . MET   A 1 134 ? 3.63015   -9.83137  -37.38883 1.000 37.79825 ? 330 MET   A O   1 
ATOM   912  C CB  . MET   A 1 134 ? 3.87641   -12.12635 -35.00979 1.000 29.04957 ? 330 MET   A CB  1 
ATOM   913  C CG  . MET   A 1 134 ? 5.31381   -11.75672 -35.33267 1.000 33.21800 ? 330 MET   A CG  1 
ATOM   914  S SD  . MET   A 1 134 ? 6.50096   -12.49294 -34.19554 1.000 33.97522 ? 330 MET   A SD  1 
ATOM   915  C CE  . MET   A 1 134 ? 7.44068   -11.05257 -33.70112 1.000 36.81941 ? 330 MET   A CE  1 
ATOM   916  N N   . LEU   A 1 135 ? 2.43928   -9.40560  -35.51952 1.000 30.48686 ? 331 LEU   A N   1 
ATOM   917  C CA  . LEU   A 1 135 ? 2.55259   -7.96107  -35.63954 1.000 30.24997 ? 331 LEU   A CA  1 
ATOM   918  C C   . LEU   A 1 135 ? 3.90339   -7.48608  -35.11743 1.000 32.56719 ? 331 LEU   A C   1 
ATOM   919  O O   . LEU   A 1 135 ? 4.46616   -8.05188  -34.17532 1.000 31.20087 ? 331 LEU   A O   1 
ATOM   920  C CB  . LEU   A 1 135 ? 1.42715   -7.26546  -34.87199 1.000 33.65571 ? 331 LEU   A CB  1 
ATOM   921  C CG  . LEU   A 1 135 ? 0.01533   -7.37797  -35.45090 1.000 35.60218 ? 331 LEU   A CG  1 
ATOM   922  C CD1 . LEU   A 1 135 ? -0.98385  -6.64362  -34.56781 1.000 37.20978 ? 331 LEU   A CD1 1 
ATOM   923  C CD2 . LEU   A 1 135 ? -0.02846  -6.84719  -36.87463 1.000 39.90986 ? 331 LEU   A CD2 1 
ATOM   924  N N   . VAL   A 1 136 ? 4.42527   -6.43407  -35.74733 1.000 33.02982 ? 332 VAL   A N   1 
ATOM   925  C CA  . VAL   A 1 136 ? 5.69363   -5.82696  -35.36487 1.000 34.20366 ? 332 VAL   A CA  1 
ATOM   926  C C   . VAL   A 1 136 ? 5.55024   -4.31283  -35.45426 1.000 34.76852 ? 332 VAL   A C   1 
ATOM   927  O O   . VAL   A 1 136 ? 4.58590   -3.78834  -36.01491 1.000 29.43690 ? 332 VAL   A O   1 
ATOM   928  C CB  . VAL   A 1 136 ? 6.86779   -6.30599  -36.24705 1.000 39.16689 ? 332 VAL   A CB  1 
ATOM   929  C CG1 . VAL   A 1 136 ? 7.20786   -7.76145  -35.94970 1.000 33.86883 ? 332 VAL   A CG1 1 
ATOM   930  C CG2 . VAL   A 1 136 ? 6.53945   -6.11375  -37.72076 1.000 31.46485 ? 332 VAL   A CG2 1 
ATOM   931  N N   . ALA   A 1 137 ? 6.53189   -3.61341  -34.88082 1.000 33.12122 ? 333 ALA   A N   1 
ATOM   932  C CA  . ALA   A 1 137 ? 6.61970   -2.15346  -34.94734 1.000 38.83659 ? 333 ALA   A CA  1 
ATOM   933  C C   . ALA   A 1 137 ? 5.34326   -1.48986  -34.43054 1.000 35.00570 ? 333 ALA   A C   1 
ATOM   934  O O   . ALA   A 1 137 ? 4.78754   -0.58494  -35.05767 1.000 34.49516 ? 333 ALA   A O   1 
ATOM   935  C CB  . ALA   A 1 137 ? 6.94414   -1.68823  -36.36913 1.000 38.53127 ? 333 ALA   A CB  1 
ATOM   936  N N   . TYR   A 1 138 ? 4.87742   -1.95941  -33.27131 1.000 40.96701 ? 334 TYR   A N   1 
ATOM   937  C CA  . TYR   A 1 138 ? 3.72555   -1.37479  -32.58041 1.000 39.27995 ? 334 TYR   A CA  1 
ATOM   938  C C   . TYR   A 1 138 ? 2.48071   -1.37225  -33.46507 1.000 37.70007 ? 334 TYR   A C   1 
ATOM   939  O O   . TYR   A 1 138 ? 1.72988   -0.39548  -33.51307 1.000 39.14961 ? 334 TYR   A O   1 
ATOM   940  C CB  . TYR   A 1 138 ? 4.05051   0.03319   -32.07315 1.000 36.59493 ? 334 TYR   A CB  1 
ATOM   941  C CG  . TYR   A 1 138 ? 5.30784   0.07096   -31.23370 1.000 43.34287 ? 334 TYR   A CG  1 
ATOM   942  C CD1 . TYR   A 1 138 ? 5.26453   -0.20440  -29.87301 1.000 39.35899 ? 334 TYR   A CD1 1 
ATOM   943  C CD2 . TYR   A 1 138 ? 6.54181   0.35529   -31.80578 1.000 40.27494 ? 334 TYR   A CD2 1 
ATOM   944  C CE1 . TYR   A 1 138 ? 6.41116   -0.18476  -29.10295 1.000 44.38136 ? 334 TYR   A CE1 1 
ATOM   945  C CE2 . TYR   A 1 138 ? 7.69521   0.37602   -31.04350 1.000 45.51644 ? 334 TYR   A CE2 1 
ATOM   946  C CZ  . TYR   A 1 138 ? 7.62339   0.10591   -29.69276 1.000 49.29016 ? 334 TYR   A CZ  1 
ATOM   947  O OH  . TYR   A 1 138 ? 8.76705   0.12441   -28.92858 1.000 55.95086 ? 334 TYR   A OH  1 
ATOM   948  N N   . GLY   A 1 139 ? 2.25997   -2.48043  -34.17020 1.000 31.84797 ? 335 GLY   A N   1 
ATOM   949  C CA  . GLY   A 1 139 ? 1.08812   -2.64514  -35.00194 1.000 34.82138 ? 335 GLY   A CA  1 
ATOM   950  C C   . GLY   A 1 139 ? 1.19824   -2.08047  -36.40043 1.000 37.43368 ? 335 GLY   A C   1 
ATOM   951  O O   . GLY   A 1 139 ? 0.25607   -2.23656  -37.18814 1.000 34.94390 ? 335 GLY   A O   1 
ATOM   952  N N   . ASN   A 1 140 ? 2.31088   -1.43379  -36.73958 1.000 34.27100 ? 336 ASN   A N   1 
ATOM   953  C CA  . ASN   A 1 140 ? 2.47852   -0.84445  -38.06013 1.000 39.95532 ? 336 ASN   A CA  1 
ATOM   954  C C   . ASN   A 1 140 ? 3.00511   -1.83084  -39.09380 1.000 41.56949 ? 336 ASN   A C   1 
ATOM   955  O O   . ASN   A 1 140 ? 3.03943   -1.49618  -40.28293 1.000 37.26524 ? 336 ASN   A O   1 
ATOM   956  C CB  . ASN   A 1 140 ? 3.41799   0.36352   -37.98193 1.000 33.73775 ? 336 ASN   A CB  1 
ATOM   957  C CG  . ASN   A 1 140 ? 2.79171   1.53987   -37.26041 1.000 38.41814 ? 336 ASN   A CG  1 
ATOM   958  O OD1 . ASN   A 1 140 ? 1.96904   2.26193   -37.82378 1.000 38.77522 ? 336 ASN   A OD1 1 
ATOM   959  N ND2 . ASN   A 1 140 ? 3.17767   1.73755   -36.00497 1.000 33.67213 ? 336 ASN   A ND2 1 
ATOM   960  N N   . GLY   A 1 141 ? 3.41126   -3.02920  -38.67665 1.000 34.34101 ? 337 GLY   A N   1 
ATOM   961  C CA  . GLY   A 1 141 ? 3.93229   -4.01162  -39.60273 1.000 36.46830 ? 337 GLY   A CA  1 
ATOM   962  C C   . GLY   A 1 141 ? 3.45365   -5.40422  -39.24577 1.000 40.14191 ? 337 GLY   A C   1 
ATOM   963  O O   . GLY   A 1 141 ? 2.98777   -5.66430  -38.13300 1.000 34.90701 ? 337 GLY   A O   1 
ATOM   964  N N   . PHE   A 1 142 ? 3.58041   -6.30325  -40.22031 1.000 37.07918 ? 338 PHE   A N   1 
ATOM   965  C CA  . PHE   A 1 142 ? 3.17513   -7.69765  -40.06219 1.000 35.01394 ? 338 PHE   A CA  1 
ATOM   966  C C   . PHE   A 1 142 ? 4.17636   -8.56581  -40.80959 1.000 36.72334 ? 338 PHE   A C   1 
ATOM   967  O O   . PHE   A 1 142 ? 4.19323   -8.57194  -42.04458 1.000 35.16400 ? 338 PHE   A O   1 
ATOM   968  C CB  . PHE   A 1 142 ? 1.75580   -7.92496  -40.58362 1.000 34.92950 ? 338 PHE   A CB  1 
ATOM   969  C CG  . PHE   A 1 142 ? 1.31123   -9.36001  -40.53398 1.000 36.49370 ? 338 PHE   A CG  1 
ATOM   970  C CD1 . PHE   A 1 142 ? 0.78360   -9.89606  -39.37000 1.000 35.81755 ? 338 PHE   A CD1 1 
ATOM   971  C CD2 . PHE   A 1 142 ? 1.41261   -10.17108 -41.65343 1.000 37.33052 ? 338 PHE   A CD2 1 
ATOM   972  C CE1 . PHE   A 1 142 ? 0.36978   -11.21502 -39.32203 1.000 36.43489 ? 338 PHE   A CE1 1 
ATOM   973  C CE2 . PHE   A 1 142 ? 1.00142   -11.49097 -41.61140 1.000 40.12029 ? 338 PHE   A CE2 1 
ATOM   974  C CZ  . PHE   A 1 142 ? 0.47845   -12.01300 -40.44468 1.000 40.83860 ? 338 PHE   A CZ  1 
ATOM   975  N N   . ILE   A 1 143 ? 5.00556   -9.29413  -40.06712 1.000 32.54678 ? 339 ILE   A N   1 
ATOM   976  C CA  . ILE   A 1 143 ? 6.02186   -10.16592 -40.64419 1.000 36.41670 ? 339 ILE   A CA  1 
ATOM   977  C C   . ILE   A 1 143 ? 5.47029   -11.58396 -40.70326 1.000 42.85247 ? 339 ILE   A C   1 
ATOM   978  O O   . ILE   A 1 143 ? 4.82712   -12.05695 -39.75653 1.000 33.50939 ? 339 ILE   A O   1 
ATOM   979  C CB  . ILE   A 1 143 ? 7.33811   -10.09010 -39.84212 1.000 37.66364 ? 339 ILE   A CB  1 
ATOM   980  C CG1 . ILE   A 1 143 ? 8.46468   -10.82173 -40.57412 1.000 35.26960 ? 339 ILE   A CG1 1 
ATOM   981  C CG2 . ILE   A 1 143 ? 7.16077   -10.61446 -38.41950 1.000 36.51746 ? 339 ILE   A CG2 1 
ATOM   982  C CD1 . ILE   A 1 143 ? 9.83841   -10.26179 -40.27283 1.000 38.87498 ? 339 ILE   A CD1 1 
ATOM   983  N N   . THR   A 1 144 ? 5.69766   -12.25798 -41.82743 1.000 37.91212 ? 340 THR   A N   1 
ATOM   984  C CA  . THR   A 1 144 ? 5.08380   -13.55761 -42.04716 1.000 39.15192 ? 340 THR   A CA  1 
ATOM   985  C C   . THR   A 1 144 ? 5.87615   -14.66171 -41.35360 1.000 35.68801 ? 340 THR   A C   1 
ATOM   986  O O   . THR   A 1 144 ? 7.07484   -14.53705 -41.08778 1.000 33.65586 ? 340 THR   A O   1 
ATOM   987  C CB  . THR   A 1 144 ? 4.96689   -13.86055 -43.54205 1.000 38.07042 ? 340 THR   A CB  1 
ATOM   988  O OG1 . THR   A 1 144 ? 6.27199   -14.06532 -44.09547 1.000 41.40525 ? 340 THR   A OG1 1 
ATOM   989  C CG2 . THR   A 1 144 ? 4.28792   -12.70924 -44.26591 1.000 39.99550 ? 340 THR   A CG2 1 
ATOM   990  N N   . ARG   A 1 145 ? 5.17642   -15.76093 -41.06260 1.000 39.08647 ? 341 ARG   A N   1 
ATOM   991  C CA  . ARG   A 1 145 ? 5.80437   -16.88768 -40.38052 1.000 40.82442 ? 341 ARG   A CA  1 
ATOM   992  C C   . ARG   A 1 145 ? 6.84946   -17.56056 -41.26263 1.000 39.19189 ? 341 ARG   A C   1 
ATOM   993  O O   . ARG   A 1 145 ? 7.89888   -17.99325 -40.77117 1.000 41.17553 ? 341 ARG   A O   1 
ATOM   994  C CB  . ARG   A 1 145 ? 4.73608   -17.89278 -39.95037 1.000 38.91713 ? 341 ARG   A CB  1 
ATOM   995  C CG  . ARG   A 1 145 ? 5.18882   -18.87513 -38.88525 1.000 36.39094 ? 341 ARG   A CG  1 
ATOM   996  C CD  . ARG   A 1 145 ? 4.04819   -19.79005 -38.46675 1.000 33.70816 ? 341 ARG   A CD  1 
ATOM   997  N NE  . ARG   A 1 145 ? 4.51457   -20.91027 -37.65864 1.000 38.91615 ? 341 ARG   A NE  1 
ATOM   998  C CZ  . ARG   A 1 145 ? 3.71889   -21.80150 -37.08299 1.000 40.40317 ? 341 ARG   A CZ  1 
ATOM   999  N NH1 . ARG   A 1 145 ? 4.20518   -22.79408 -36.35576 1.000 42.02452 ? 341 ARG   A NH1 1 
ATOM   1000 N NH2 . ARG   A 1 145 ? 2.40239   -21.69313 -37.23947 1.000 31.08990 ? 341 ARG   A NH2 1 
ATOM   1001 N N   . GLU   A 1 146 ? 6.58251   -17.65725 -42.56691 1.000 42.12274 ? 342 GLU   A N   1 
ATOM   1002 C CA  . GLU   A 1 146 ? 7.52459   -18.31880 -43.46428 1.000 47.71063 ? 342 GLU   A CA  1 
ATOM   1003 C C   . GLU   A 1 146 ? 8.79694   -17.49878 -43.63815 1.000 44.94680 ? 342 GLU   A C   1 
ATOM   1004 O O   . GLU   A 1 146 ? 9.89513   -18.06059 -43.72300 1.000 49.24780 ? 342 GLU   A O   1 
ATOM   1005 C CB  . GLU   A 1 146 ? 6.86491   -18.58298 -44.81766 1.000 47.82868 ? 342 GLU   A CB  1 
ATOM   1006 C CG  . GLU   A 1 146 ? 5.54638   -19.33724 -44.73092 1.000 51.60218 ? 342 GLU   A CG  1 
ATOM   1007 C CD  . GLU   A 1 146 ? 5.72694   -20.84406 -44.76327 1.000 59.99843 ? 342 GLU   A CD  1 
ATOM   1008 O OE1 . GLU   A 1 146 ? 6.59503   -21.36018 -44.02746 1.000 59.89219 ? 342 GLU   A OE1 1 
ATOM   1009 O OE2 . GLU   A 1 146 ? 4.99822   -21.51367 -45.52596 1.000 69.56190 ? 342 GLU   A OE2 1 
ATOM   1010 N N   . PHE   A 1 147 ? 8.67245   -16.17004 -43.69201 1.000 45.52080 ? 343 PHE   A N   1 
ATOM   1011 C CA  . PHE   A 1 147 ? 9.85583   -15.32845 -43.83864 1.000 42.60644 ? 343 PHE   A CA  1 
ATOM   1012 C C   . PHE   A 1 147 ? 10.76560  -15.44069 -42.62167 1.000 46.26593 ? 343 PHE   A C   1 
ATOM   1013 O O   . PHE   A 1 147 ? 11.99474  -15.38376 -42.74817 1.000 41.36235 ? 343 PHE   A O   1 
ATOM   1014 C CB  . PHE   A 1 147 ? 9.44548   -13.87472 -44.07119 1.000 41.18306 ? 343 PHE   A CB  1 
ATOM   1015 C CG  . PHE   A 1 147 ? 10.60618  -12.92763 -44.16395 1.000 45.08951 ? 343 PHE   A CG  1 
ATOM   1016 C CD1 . PHE   A 1 147 ? 11.62458  -13.14678 -45.07732 1.000 44.25264 ? 343 PHE   A CD1 1 
ATOM   1017 C CD2 . PHE   A 1 147 ? 10.68252  -11.82087 -43.33534 1.000 46.67702 ? 343 PHE   A CD2 1 
ATOM   1018 C CE1 . PHE   A 1 147 ? 12.69639  -12.27813 -45.16433 1.000 47.61139 ? 343 PHE   A CE1 1 
ATOM   1019 C CE2 . PHE   A 1 147 ? 11.75204  -10.94789 -43.41673 1.000 41.85370 ? 343 PHE   A CE2 1 
ATOM   1020 C CZ  . PHE   A 1 147 ? 12.76029  -11.17685 -44.33288 1.000 43.11860 ? 343 PHE   A CZ  1 
ATOM   1021 N N   . LEU   A 1 148 ? 10.18071  -15.59848 -41.43190 1.000 42.94784 ? 344 LEU   A N   1 
ATOM   1022 C CA  . LEU   A 1 148 ? 10.99201  -15.82114 -40.23992 1.000 41.50470 ? 344 LEU   A CA  1 
ATOM   1023 C C   . LEU   A 1 148 ? 11.67835  -17.17975 -40.29172 1.000 39.36732 ? 344 LEU   A C   1 
ATOM   1024 O O   . LEU   A 1 148 ? 12.83367  -17.31517 -39.87263 1.000 42.05589 ? 344 LEU   A O   1 
ATOM   1025 C CB  . LEU   A 1 148 ? 10.12848  -15.70192 -38.98517 1.000 35.79109 ? 344 LEU   A CB  1 
ATOM   1026 C CG  . LEU   A 1 148 ? 9.58420   -14.30624 -38.67847 1.000 40.39589 ? 344 LEU   A CG  1 
ATOM   1027 C CD1 . LEU   A 1 148 ? 8.59004   -14.35859 -37.52730 1.000 42.81142 ? 344 LEU   A CD1 1 
ATOM   1028 C CD2 . LEU   A 1 148 ? 10.72226  -13.34617 -38.37069 1.000 32.45744 ? 344 LEU   A CD2 1 
ATOM   1029 N N   . LYS   A 1 149 ? 10.98176  -18.19751 -40.80270 1.000 42.67969 ? 345 LYS   A N   1 
ATOM   1030 C CA  . LYS   A 1 149 ? 11.60006  -19.50777 -40.96865 1.000 43.60959 ? 345 LYS   A CA  1 
ATOM   1031 C C   . LYS   A 1 149 ? 12.61327  -19.50746 -42.10517 1.000 50.65444 ? 345 LYS   A C   1 
ATOM   1032 O O   . LYS   A 1 149 ? 13.57914  -20.27879 -42.07328 1.000 44.64831 ? 345 LYS   A O   1 
ATOM   1033 C CB  . LYS   A 1 149 ? 10.52687  -20.56715 -41.21690 1.000 39.52865 ? 345 LYS   A CB  1 
ATOM   1034 C CG  . LYS   A 1 149 ? 10.14334  -21.36481 -39.98281 1.000 47.32075 ? 345 LYS   A CG  1 
ATOM   1035 C CD  . LYS   A 1 149 ? 9.15668   -22.46859 -40.32541 1.000 50.37337 ? 345 LYS   A CD  1 
ATOM   1036 C CE  . LYS   A 1 149 ? 7.95449   -21.92011 -41.07577 1.000 47.70029 ? 345 LYS   A CE  1 
ATOM   1037 N NZ  . LYS   A 1 149 ? 7.08431   -23.01140 -41.59634 1.000 50.92192 ? 345 LYS   A NZ  1 
ATOM   1038 N N   . SER   A 1 150 ? 12.41325  -18.65329 -43.11144 1.000 49.51907 ? 346 SER   A N   1 
ATOM   1039 C CA  . SER   A 1 150 ? 13.33412  -18.57430 -44.23810 1.000 48.75154 ? 346 SER   A CA  1 
ATOM   1040 C C   . SER   A 1 150 ? 14.65046  -17.89826 -43.87975 1.000 48.56331 ? 346 SER   A C   1 
ATOM   1041 O O   . SER   A 1 150 ? 15.57076  -17.90363 -44.70361 1.000 54.52559 ? 346 SER   A O   1 
ATOM   1042 C CB  . SER   A 1 150 ? 12.67188  -17.83565 -45.40386 1.000 47.48405 ? 346 SER   A CB  1 
ATOM   1043 O OG  . SER   A 1 150 ? 12.95394  -16.44769 -45.35576 1.000 49.96986 ? 346 SER   A OG  1 
ATOM   1044 N N   . LEU   A 1 151 ? 14.76424  -17.32316 -42.68499 1.000 50.46975 ? 347 LEU   A N   1 
ATOM   1045 C CA  . LEU   A 1 151 ? 16.00686  -16.69650 -42.26830 1.000 42.20753 ? 347 LEU   A CA  1 
ATOM   1046 C C   . LEU   A 1 151 ? 17.06925  -17.75759 -41.98582 1.000 53.51352 ? 347 LEU   A C   1 
ATOM   1047 O O   . LEU   A 1 151 ? 16.79927  -18.96223 -41.95385 1.000 52.47772 ? 347 LEU   A O   1 
ATOM   1048 C CB  . LEU   A 1 151 ? 15.78407  -15.83093 -41.02846 1.000 47.63696 ? 347 LEU   A CB  1 
ATOM   1049 C CG  . LEU   A 1 151 ? 14.84721  -14.63025 -41.17905 1.000 45.89115 ? 347 LEU   A CG  1 
ATOM   1050 C CD1 . LEU   A 1 151 ? 14.74699  -13.86665 -39.86791 1.000 42.85577 ? 347 LEU   A CD1 1 
ATOM   1051 C CD2 . LEU   A 1 151 ? 15.30695  -13.71533 -42.30375 1.000 41.77441 ? 347 LEU   A CD2 1 
ATOM   1052 N N   . ARG   A 1 152 ? 18.29645  -17.29227 -41.77504 1.000 47.78003 ? 348 ARG   A N   1 
ATOM   1053 C CA  . ARG   A 1 152 ? 19.39631  -18.19609 -41.48233 1.000 55.96071 ? 348 ARG   A CA  1 
ATOM   1054 C C   . ARG   A 1 152 ? 19.40208  -18.57404 -40.00303 1.000 57.74015 ? 348 ARG   A C   1 
ATOM   1055 O O   . ARG   A 1 152 ? 18.86881  -17.86186 -39.15003 1.000 55.63332 ? 348 ARG   A O   1 
ATOM   1056 C CB  . ARG   A 1 152 ? 20.73346  -17.56234 -41.87355 1.000 51.87272 ? 348 ARG   A CB  1 
ATOM   1057 C CG  . ARG   A 1 152 ? 21.49481  -16.95551 -40.70731 1.000 54.04754 ? 348 ARG   A CG  1 
ATOM   1058 C CD  . ARG   A 1 152 ? 22.98178  -16.85569 -40.99474 1.000 53.28670 ? 348 ARG   A CD  1 
ATOM   1059 N NE  . ARG   A 1 152 ? 23.73555  -16.50845 -39.79634 1.000 53.28243 ? 348 ARG   A NE  1 
ATOM   1060 C CZ  . ARG   A 1 152 ? 24.12343  -15.27874 -39.48918 1.000 49.86430 ? 348 ARG   A CZ  1 
ATOM   1061 N NH1 . ARG   A 1 152 ? 24.79444  -15.02179 -38.37818 1.000 50.84277 ? 348 ARG   A NH1 1 
ATOM   1062 N NH2 . ARG   A 1 152 ? 23.82830  -14.28135 -40.31648 1.000 45.27282 ? 348 ARG   A NH2 1 
ATOM   1063 N N   . LYS   A 1 153 ? 20.01185  -19.71877 -39.70760 1.000 52.77263 ? 349 LYS   A N   1 
ATOM   1064 C CA  . LYS   A 1 153 ? 20.11755  -20.17072 -38.33186 1.000 54.97346 ? 349 LYS   A CA  1 
ATOM   1065 C C   . LYS   A 1 153 ? 21.13355  -19.31781 -37.57191 1.000 56.41365 ? 349 LYS   A C   1 
ATOM   1066 O O   . LYS   A 1 153 ? 22.11608  -18.84309 -38.15009 1.000 59.12708 ? 349 LYS   A O   1 
ATOM   1067 C CB  . LYS   A 1 153 ? 20.52813  -21.63980 -38.28237 1.000 53.83182 ? 349 LYS   A CB  1 
ATOM   1068 C CG  . LYS   A 1 153 ? 19.57785  -22.57115 -39.01863 1.000 58.36515 ? 349 LYS   A CG  1 
ATOM   1069 C CD  . LYS   A 1 153 ? 19.85789  -24.02743 -38.69023 1.000 62.33210 ? 349 LYS   A CD  1 
ATOM   1070 C CE  . LYS   A 1 153 ? 18.58463  -24.76304 -38.30147 1.000 63.79105 ? 349 LYS   A CE  1 
ATOM   1071 N NZ  . LYS   A 1 153 ? 18.44213  -24.91485 -36.82540 1.000 55.81306 ? 349 LYS   A NZ  1 
ATOM   1072 N N   . PRO   A 1 154 ? 20.91901  -19.10523 -36.26348 1.000 57.16422 ? 350 PRO   A N   1 
ATOM   1073 C CA  . PRO   A 1 154 ? 19.81805  -19.64118 -35.45989 1.000 50.79555 ? 350 PRO   A CA  1 
ATOM   1074 C C   . PRO   A 1 154 ? 18.62354  -18.69168 -35.35068 1.000 50.28829 ? 350 PRO   A C   1 
ATOM   1075 O O   . PRO   A 1 154 ? 17.74143  -18.89864 -34.51672 1.000 50.49802 ? 350 PRO   A O   1 
ATOM   1076 C CB  . PRO   A 1 154 ? 20.48317  -19.84514 -34.09898 1.000 51.24338 ? 350 PRO   A CB  1 
ATOM   1077 C CG  . PRO   A 1 154 ? 21.46574  -18.67909 -34.00816 1.000 54.99424 ? 350 PRO   A CG  1 
ATOM   1078 C CD  . PRO   A 1 154 ? 21.77674  -18.23050 -35.44348 1.000 54.40265 ? 350 PRO   A CD  1 
ATOM   1079 N N   . PHE   A 1 155 ? 18.59469  -17.66658 -36.20426 1.000 50.87338 ? 351 PHE   A N   1 
ATOM   1080 C CA  . PHE   A 1 155 ? 17.53020  -16.67310 -36.13896 1.000 47.84255 ? 351 PHE   A CA  1 
ATOM   1081 C C   . PHE   A 1 155 ? 16.18556  -17.22631 -36.59391 1.000 47.49071 ? 351 PHE   A C   1 
ATOM   1082 O O   . PHE   A 1 155 ? 15.14412  -16.69996 -36.18705 1.000 45.37909 ? 351 PHE   A O   1 
ATOM   1083 C CB  . PHE   A 1 155 ? 17.91021  -15.45022 -36.97405 1.000 43.56513 ? 351 PHE   A CB  1 
ATOM   1084 C CG  . PHE   A 1 155 ? 19.15571  -14.75970 -36.49714 1.000 48.03070 ? 351 PHE   A CG  1 
ATOM   1085 C CD1 . PHE   A 1 155 ? 19.09755  -13.82569 -35.47686 1.000 44.21087 ? 351 PHE   A CD1 1 
ATOM   1086 C CD2 . PHE   A 1 155 ? 20.38585  -15.04959 -37.06425 1.000 49.35889 ? 351 PHE   A CD2 1 
ATOM   1087 C CE1 . PHE   A 1 155 ? 20.24155  -13.19117 -35.03155 1.000 51.48508 ? 351 PHE   A CE1 1 
ATOM   1088 C CE2 . PHE   A 1 155 ? 21.53390  -14.41755 -36.62453 1.000 48.19189 ? 351 PHE   A CE2 1 
ATOM   1089 C CZ  . PHE   A 1 155 ? 21.46158  -13.48738 -35.60667 1.000 53.08673 ? 351 PHE   A CZ  1 
ATOM   1090 N N   . CYS   A 1 156 ? 16.18027  -18.27194 -37.41964 1.000 48.63911 ? 352 CYS   A N   1 
ATOM   1091 C CA  . CYS   A 1 156 ? 14.93160  -18.87760 -37.86163 1.000 41.66091 ? 352 CYS   A CA  1 
ATOM   1092 C C   . CYS   A 1 156 ? 14.35533  -19.85695 -36.84832 1.000 40.51065 ? 352 CYS   A C   1 
ATOM   1093 O O   . CYS   A 1 156 ? 13.22058  -20.31143 -37.02906 1.000 50.23981 ? 352 CYS   A O   1 
ATOM   1094 C CB  . CYS   A 1 156 ? 15.13610  -19.59067 -39.20001 1.000 48.88817 ? 352 CYS   A CB  1 
ATOM   1095 S SG  . CYS   A 1 156 ? 16.42975  -20.85240 -39.18140 1.000 50.02061 ? 352 CYS   A SG  1 
ATOM   1096 N N   . ASP   A 1 157 ? 15.10100  -20.19207 -35.79548 1.000 44.85150 ? 353 ASP   A N   1 
ATOM   1097 C CA  . ASP   A 1 157 ? 14.64242  -21.11458 -34.76613 1.000 49.43208 ? 353 ASP   A CA  1 
ATOM   1098 C C   . ASP   A 1 157 ? 14.15309  -20.39317 -33.51587 1.000 48.76458 ? 353 ASP   A C   1 
ATOM   1099 O O   . ASP   A 1 157 ? 14.01887  -21.01853 -32.45815 1.000 43.81163 ? 353 ASP   A O   1 
ATOM   1100 C CB  . ASP   A 1 157 ? 15.75836  -22.09458 -34.40101 1.000 48.64312 ? 353 ASP   A CB  1 
ATOM   1101 C CG  . ASP   A 1 157 ? 16.39056  -22.73937 -35.61823 1.000 50.35424 ? 353 ASP   A CG  1 
ATOM   1102 O OD1 . ASP   A 1 157 ? 15.66687  -22.98984 -36.60512 1.000 55.76378 ? 353 ASP   A OD1 1 
ATOM   1103 O OD2 . ASP   A 1 157 ? 17.61229  -22.99685 -35.58687 1.000 53.79884 ? 353 ASP   A OD2 1 
ATOM   1104 N N   . ILE   A 1 158 ? 13.87840  -19.09394 -33.61607 1.000 42.38945 ? 354 ILE   A N   1 
ATOM   1105 C CA  . ILE   A 1 158 ? 13.54349  -18.29097 -32.44611 1.000 43.67383 ? 354 ILE   A CA  1 
ATOM   1106 C C   . ILE   A 1 158 ? 12.03489  -18.26664 -32.23659 1.000 38.04038 ? 354 ILE   A C   1 
ATOM   1107 O O   . ILE   A 1 158 ? 11.53734  -18.69698 -31.19020 1.000 36.13681 ? 354 ILE   A O   1 
ATOM   1108 C CB  . ILE   A 1 158 ? 14.10283  -16.86317 -32.57801 1.000 46.12951 ? 354 ILE   A CB  1 
ATOM   1109 C CG1 . ILE   A 1 158 ? 15.62214  -16.90857 -32.77436 1.000 45.18665 ? 354 ILE   A CG1 1 
ATOM   1110 C CG2 . ILE   A 1 158 ? 13.72820  -16.03653 -31.35305 1.000 42.14007 ? 354 ILE   A CG2 1 
ATOM   1111 C CD1 . ILE   A 1 158 ? 16.35759  -15.68510 -32.26713 1.000 43.73764 ? 354 ILE   A CD1 1 
ATOM   1112 N N   . MET   A 1 159 ? 11.29524  -17.76696 -33.22475 1.000 33.89999 ? 355 MET   A N   1 
ATOM   1113 C CA  . MET   A 1 159 ? 9.85980   -17.57353 -33.06937 1.000 35.31518 ? 355 MET   A CA  1 
ATOM   1114 C C   . MET   A 1 159 ? 9.03041   -18.80172 -33.41173 1.000 39.11708 ? 355 MET   A C   1 
ATOM   1115 O O   . MET   A 1 159 ? 7.84319   -18.83413 -33.06924 1.000 32.91868 ? 355 MET   A O   1 
ATOM   1116 C CB  . MET   A 1 159 ? 9.38272   -16.39731 -33.92479 1.000 41.31699 ? 355 MET   A CB  1 
ATOM   1117 C CG  . MET   A 1 159 ? 9.95460   -15.06149 -33.50216 1.000 43.34693 ? 355 MET   A CG  1 
ATOM   1118 S SD  . MET   A 1 159 ? 8.95565   -14.32068 -32.19749 1.000 40.92561 ? 355 MET   A SD  1 
ATOM   1119 C CE  . MET   A 1 159 ? 9.91374   -14.76192 -30.75116 1.000 32.72789 ? 355 MET   A CE  1 
ATOM   1120 N N   . GLU   A 1 160 ? 9.61091   -19.80050 -34.07489 1.000 41.48919 ? 356 GLU   A N   1 
ATOM   1121 C CA  . GLU   A 1 160 ? 8.83675   -20.98628 -34.43933 1.000 41.14743 ? 356 GLU   A CA  1 
ATOM   1122 C C   . GLU   A 1 160 ? 8.23575   -21.69877 -33.23227 1.000 31.94410 ? 356 GLU   A C   1 
ATOM   1123 O O   . GLU   A 1 160 ? 7.03559   -22.02245 -33.27478 1.000 36.21464 ? 356 GLU   A O   1 
ATOM   1124 C CB  . GLU   A 1 160 ? 9.70184   -21.93079 -35.28139 1.000 44.83588 ? 356 GLU   A CB  1 
ATOM   1125 C CG  . GLU   A 1 160 ? 8.90744   -22.98095 -36.04522 1.000 48.65848 ? 356 GLU   A CG  1 
ATOM   1126 C CD  . GLU   A 1 160 ? 7.76970   -22.38516 -36.85393 1.000 43.51482 ? 356 GLU   A CD  1 
ATOM   1127 O OE1 . GLU   A 1 160 ? 6.67176   -22.98051 -36.86266 1.000 53.43593 ? 356 GLU   A OE1 1 
ATOM   1128 O OE2 . GLU   A 1 160 ? 7.97036   -21.32485 -37.48309 1.000 47.51221 ? 356 GLU   A OE2 1 
ATOM   1129 N N   . PRO   A 1 161 ? 8.96975   -21.97273 -32.14439 1.000 33.48598 ? 357 PRO   A N   1 
ATOM   1130 C CA  . PRO   A 1 161 ? 8.30982   -22.56716 -30.96920 1.000 33.98201 ? 357 PRO   A CA  1 
ATOM   1131 C C   . PRO   A 1 161 ? 7.33117   -21.62456 -30.29258 1.000 35.27571 ? 357 PRO   A C   1 
ATOM   1132 O O   . PRO   A 1 161 ? 6.45421   -22.09159 -29.55489 1.000 33.50904 ? 357 PRO   A O   1 
ATOM   1133 C CB  . PRO   A 1 161 ? 9.47695   -22.92354 -30.03476 1.000 35.67906 ? 357 PRO   A CB  1 
ATOM   1134 C CG  . PRO   A 1 161 ? 10.72258  -22.75432 -30.83963 1.000 37.80703 ? 357 PRO   A CG  1 
ATOM   1135 C CD  . PRO   A 1 161 ? 10.41362  -21.77888 -31.91717 1.000 37.08933 ? 357 PRO   A CD  1 
ATOM   1136 N N   . LYS   A 1 162 ? 7.45135   -20.31603 -30.52040 1.000 32.10831 ? 358 LYS   A N   1 
ATOM   1137 C CA  . LYS   A 1 162 ? 6.49743   -19.36690 -29.95827 1.000 27.99515 ? 358 LYS   A CA  1 
ATOM   1138 C C   . LYS   A 1 162 ? 5.19151   -19.38195 -30.74153 1.000 32.30608 ? 358 LYS   A C   1 
ATOM   1139 O O   . LYS   A 1 162 ? 4.11153   -19.24119 -30.15666 1.000 30.35664 ? 358 LYS   A O   1 
ATOM   1140 C CB  . LYS   A 1 162 ? 7.09931   -17.95806 -29.93801 1.000 28.74770 ? 358 LYS   A CB  1 
ATOM   1141 C CG  . LYS   A 1 162 ? 8.04426   -17.67954 -28.76603 1.000 29.71744 ? 358 LYS   A CG  1 
ATOM   1142 C CD  . LYS   A 1 162 ? 9.28792   -18.55835 -28.82926 1.000 29.88267 ? 358 LYS   A CD  1 
ATOM   1143 C CE  . LYS   A 1 162 ? 10.49968  -17.90580 -28.19772 1.000 34.22937 ? 358 LYS   A CE  1 
ATOM   1144 N NZ  . LYS   A 1 162 ? 11.68269  -18.80491 -28.30738 1.000 31.94181 ? 358 LYS   A NZ  1 
ATOM   1145 N N   . PHE   A 1 163 ? 5.27406   -19.55591 -32.06394 1.000 27.52908 ? 359 PHE   A N   1 
ATOM   1146 C CA  . PHE   A 1 163 ? 4.06780   -19.73483 -32.86489 1.000 28.78778 ? 359 PHE   A CA  1 
ATOM   1147 C C   . PHE   A 1 163 ? 3.32781   -21.00293 -32.46034 1.000 32.76485 ? 359 PHE   A C   1 
ATOM   1148 O O   . PHE   A 1 163 ? 2.09448   -21.00802 -32.36491 1.000 31.70795 ? 359 PHE   A O   1 
ATOM   1149 C CB  . PHE   A 1 163 ? 4.42287   -19.78021 -34.35179 1.000 36.11611 ? 359 PHE   A CB  1 
ATOM   1150 C CG  . PHE   A 1 163 ? 4.54287   -18.42698 -34.99364 1.000 34.19748 ? 359 PHE   A CG  1 
ATOM   1151 C CD1 . PHE   A 1 163 ? 3.41557   -17.66898 -35.26079 1.000 32.47520 ? 359 PHE   A CD1 1 
ATOM   1152 C CD2 . PHE   A 1 163 ? 5.78408   -17.91824 -35.33971 1.000 37.55064 ? 359 PHE   A CD2 1 
ATOM   1153 C CE1 . PHE   A 1 163 ? 3.52349   -16.42434 -35.85614 1.000 35.59246 ? 359 PHE   A CE1 1 
ATOM   1154 C CE2 . PHE   A 1 163 ? 5.89931   -16.67443 -35.93490 1.000 35.42775 ? 359 PHE   A CE2 1 
ATOM   1155 C CZ  . PHE   A 1 163 ? 4.76694   -15.92728 -36.19345 1.000 35.58067 ? 359 PHE   A CZ  1 
ATOM   1156 N N   . ASP   A 1 164 ? 4.06724   -22.09046 -32.22056 1.000 30.34799 ? 360 ASP   A N   1 
ATOM   1157 C CA  . ASP   A 1 164 ? 3.43719   -23.33986 -31.80517 1.000 35.18924 ? 360 ASP   A CA  1 
ATOM   1158 C C   . ASP   A 1 164 ? 2.73121   -23.18017 -30.46551 1.000 30.72848 ? 360 ASP   A C   1 
ATOM   1159 O O   . ASP   A 1 164 ? 1.60714   -23.66380 -30.28593 1.000 31.27564 ? 360 ASP   A O   1 
ATOM   1160 C CB  . ASP   A 1 164 ? 4.47819   -24.45707 -31.72975 1.000 31.96088 ? 360 ASP   A CB  1 
ATOM   1161 C CG  . ASP   A 1 164 ? 5.02561   -24.83722 -33.09009 1.000 33.72119 ? 360 ASP   A CG  1 
ATOM   1162 O OD1 . ASP   A 1 164 ? 6.11072   -25.45383 -33.14187 1.000 40.14100 ? 360 ASP   A OD1 1 
ATOM   1163 O OD2 . ASP   A 1 164 ? 4.37420   -24.51724 -34.10710 1.000 38.62760 ? 360 ASP   A OD2 1 
ATOM   1164 N N   . PHE   A 1 165 ? 3.37614   -22.50844 -29.50909 1.000 33.49013 ? 361 PHE   A N   1 
ATOM   1165 C CA  . PHE   A 1 165 ? 2.71348   -22.23748 -28.23877 1.000 35.43656 ? 361 PHE   A CA  1 
ATOM   1166 C C   . PHE   A 1 165 ? 1.50074   -21.33924 -28.43761 1.000 27.99950 ? 361 PHE   A C   1 
ATOM   1167 O O   . PHE   A 1 165 ? 0.44050   -21.57552 -27.84686 1.000 33.01539 ? 361 PHE   A O   1 
ATOM   1168 C CB  . PHE   A 1 165 ? 3.69017   -21.59905 -27.25039 1.000 33.58973 ? 361 PHE   A CB  1 
ATOM   1169 C CG  . PHE   A 1 165 ? 3.03673   -21.12889 -25.98072 1.000 32.46913 ? 361 PHE   A CG  1 
ATOM   1170 C CD1 . PHE   A 1 165 ? 2.84335   -22.00226 -24.92413 1.000 31.74852 ? 361 PHE   A CD1 1 
ATOM   1171 C CD2 . PHE   A 1 165 ? 2.60115   -19.81940 -25.84921 1.000 31.68170 ? 361 PHE   A CD2 1 
ATOM   1172 C CE1 . PHE   A 1 165 ? 2.23527   -21.57794 -23.75851 1.000 30.48754 ? 361 PHE   A CE1 1 
ATOM   1173 C CE2 . PHE   A 1 165 ? 1.98931   -19.39123 -24.68775 1.000 32.53473 ? 361 PHE   A CE2 1 
ATOM   1174 C CZ  . PHE   A 1 165 ? 1.80559   -20.27285 -23.64199 1.000 32.58248 ? 361 PHE   A CZ  1 
ATOM   1175 N N   . ALA   A 1 166 ? 1.64050   -20.30182 -29.26899 1.000 31.70070 ? 362 ALA   A N   1 
ATOM   1176 C CA  . ALA   A 1 166 ? 0.54995   -19.35409 -29.47462 1.000 30.74003 ? 362 ALA   A CA  1 
ATOM   1177 C C   . ALA   A 1 166 ? -0.65707  -20.01161 -30.12575 1.000 32.72408 ? 362 ALA   A C   1 
ATOM   1178 O O   . ALA   A 1 166 ? -1.79869  -19.63850 -29.83259 1.000 33.36185 ? 362 ALA   A O   1 
ATOM   1179 C CB  . ALA   A 1 166 ? 1.02696   -18.18027 -30.32960 1.000 29.53969 ? 362 ALA   A CB  1 
ATOM   1180 N N   . MET   A 1 167 ? -0.43003  -20.98155 -31.01430 1.000 30.58372 ? 363 MET   A N   1 
ATOM   1181 C CA  . MET   A 1 167 ? -1.54593  -21.62954 -31.69527 1.000 37.53140 ? 363 MET   A CA  1 
ATOM   1182 C C   . MET   A 1 167 ? -2.41013  -22.41182 -30.71342 1.000 29.28124 ? 363 MET   A C   1 
ATOM   1183 O O   . MET   A 1 167 ? -3.64288  -22.35444 -30.78263 1.000 31.08179 ? 363 MET   A O   1 
ATOM   1184 C CB  . MET   A 1 167 ? -1.02270  -22.53996 -32.80647 1.000 35.50591 ? 363 MET   A CB  1 
ATOM   1185 C CG  . MET   A 1 167 ? -0.59669  -21.84933 -34.11831 1.000 36.04942 ? 363 MET   A CG  1 
ATOM   1186 S SD  . MET   A 1 167 ? -1.40990  -20.31144 -34.63692 1.000 39.25385 ? 363 MET   A SD  1 
ATOM   1187 C CE  . MET   A 1 167 ? -0.53574  -19.04259 -33.71040 1.000 31.93875 ? 363 MET   A CE  1 
ATOM   1188 N N   . LYS   A 1 168 ? -1.78391  -23.14151 -29.78639 1.000 29.26604 ? 364 LYS   A N   1 
ATOM   1189 C CA  . LYS   A 1 168 ? -2.55320  -23.84705 -28.76635 1.000 35.73835 ? 364 LYS   A CA  1 
ATOM   1190 C C   . LYS   A 1 168 ? -3.11577  -22.88636 -27.72681 1.000 36.72458 ? 364 LYS   A C   1 
ATOM   1191 O O   . LYS   A 1 168 ? -4.22606  -23.09822 -27.22576 1.000 34.81695 ? 364 LYS   A O   1 
ATOM   1192 C CB  . LYS   A 1 168 ? -1.68674  -24.91069 -28.09069 1.000 33.10528 ? 364 LYS   A CB  1 
ATOM   1193 C CG  . LYS   A 1 168 ? -0.99969  -25.86018 -29.05824 1.000 39.88596 ? 364 LYS   A CG  1 
ATOM   1194 C CD  . LYS   A 1 168 ? -1.94888  -26.94375 -29.53511 1.000 39.10978 ? 364 LYS   A CD  1 
ATOM   1195 C CE  . LYS   A 1 168 ? -1.86134  -28.17778 -28.65480 1.000 45.84621 ? 364 LYS   A CE  1 
ATOM   1196 N NZ  . LYS   A 1 168 ? -3.20691  -28.74558 -28.36705 1.000 41.39398 ? 364 LYS   A NZ  1 
ATOM   1197 N N   . PHE   A 1 169 ? -2.37200  -21.82759 -27.39607 1.000 30.75928 ? 365 PHE   A N   1 
ATOM   1198 C CA  . PHE   A 1 169 ? -2.85246  -20.86098 -26.41365 1.000 33.42566 ? 365 PHE   A CA  1 
ATOM   1199 C C   . PHE   A 1 169 ? -4.03534  -20.06460 -26.95193 1.000 28.60308 ? 365 PHE   A C   1 
ATOM   1200 O O   . PHE   A 1 169 ? -5.00549  -19.81780 -26.22578 1.000 30.40792 ? 365 PHE   A O   1 
ATOM   1201 C CB  . PHE   A 1 169 ? -1.71465  -19.92611 -26.00198 1.000 33.58721 ? 365 PHE   A CB  1 
ATOM   1202 C CG  . PHE   A 1 169 ? -2.00648  -19.11647 -24.76873 1.000 33.82459 ? 365 PHE   A CG  1 
ATOM   1203 C CD1 . PHE   A 1 169 ? -1.90922  -19.68728 -23.51031 1.000 30.00669 ? 365 PHE   A CD1 1 
ATOM   1204 C CD2 . PHE   A 1 169 ? -2.36957  -17.78241 -24.86811 1.000 29.64470 ? 365 PHE   A CD2 1 
ATOM   1205 C CE1 . PHE   A 1 169 ? -2.17292  -18.94487 -22.37335 1.000 30.45669 ? 365 PHE   A CE1 1 
ATOM   1206 C CE2 . PHE   A 1 169 ? -2.63513  -17.03394 -23.73504 1.000 34.12528 ? 365 PHE   A CE2 1 
ATOM   1207 C CZ  . PHE   A 1 169 ? -2.53711  -17.61715 -22.48569 1.000 28.27476 ? 365 PHE   A CZ  1 
ATOM   1208 N N   . ASN   A 1 170 ? -3.97650  -19.65516 -28.22222 1.000 31.20621 ? 366 ASN   A N   1 
ATOM   1209 C CA  . ASN   A 1 170 ? -5.07162  -18.89081 -28.80986 1.000 26.73352 ? 366 ASN   A CA  1 
ATOM   1210 C C   . ASN   A 1 170 ? -6.33687  -19.72189 -28.97846 1.000 34.14171 ? 366 ASN   A C   1 
ATOM   1211 O O   . ASN   A 1 170 ? -7.43139  -19.15148 -29.04357 1.000 33.48079 ? 366 ASN   A O   1 
ATOM   1212 C CB  . ASN   A 1 170 ? -4.64683  -18.30910 -30.15981 1.000 28.57083 ? 366 ASN   A CB  1 
ATOM   1213 C CG  . ASN   A 1 170 ? -3.69515  -17.13556 -30.01437 1.000 36.41164 ? 366 ASN   A CG  1 
ATOM   1214 O OD1 . ASN   A 1 170 ? -3.45262  -16.65324 -28.90769 1.000 30.89525 ? 366 ASN   A OD1 1 
ATOM   1215 N ND2 . ASN   A 1 170 ? -3.14525  -16.67461 -31.13310 1.000 27.07140 ? 366 ASN   A ND2 1 
ATOM   1216 N N   . ALA   A 1 171 ? -6.21540  -21.05039 -29.05149 1.000 32.32476 ? 367 ALA   A N   1 
ATOM   1217 C CA  . ALA   A 1 171 ? -7.39729  -21.90146 -29.12775 1.000 36.13744 ? 367 ALA   A CA  1 
ATOM   1218 C C   . ALA   A 1 171 ? -8.23190  -21.84201 -27.85613 1.000 38.95009 ? 367 ALA   A C   1 
ATOM   1219 O O   . ALA   A 1 171 ? -9.42346  -22.16732 -27.89565 1.000 41.83288 ? 367 ALA   A O   1 
ATOM   1220 C CB  . ALA   A 1 171 ? -6.99285  -23.34759 -29.41721 1.000 31.07915 ? 367 ALA   A CB  1 
ATOM   1221 N N   . LEU   A 1 172 ? -7.63495  -21.43646 -26.73248 1.000 35.58524 ? 368 LEU   A N   1 
ATOM   1222 C CA  . LEU   A 1 172 ? -8.39427  -21.26495 -25.50048 1.000 36.89573 ? 368 LEU   A CA  1 
ATOM   1223 C C   . LEU   A 1 172 ? -9.34356  -20.07764 -25.57251 1.000 34.69743 ? 368 LEU   A C   1 
ATOM   1224 O O   . LEU   A 1 172 ? -10.28281 -20.00305 -24.77253 1.000 38.30057 ? 368 LEU   A O   1 
ATOM   1225 C CB  . LEU   A 1 172 ? -7.44039  -21.10442 -24.31674 1.000 32.33153 ? 368 LEU   A CB  1 
ATOM   1226 C CG  . LEU   A 1 172 ? -6.45728  -22.25841 -24.11899 1.000 31.88676 ? 368 LEU   A CG  1 
ATOM   1227 C CD1 . LEU   A 1 172 ? -5.49398  -21.95781 -22.98437 1.000 28.50279 ? 368 LEU   A CD1 1 
ATOM   1228 C CD2 . LEU   A 1 172 ? -7.20834  -23.55359 -23.86109 1.000 34.88066 ? 368 LEU   A CD2 1 
ATOM   1229 N N   . GLU   A 1 173 ? -9.11262  -19.15328 -26.50740 1.000 33.59888 ? 369 GLU   A N   1 
ATOM   1230 C CA  . GLU   A 1 173 ? -9.99997  -18.01529 -26.75112 1.000 38.69937 ? 369 GLU   A CA  1 
ATOM   1231 C C   . GLU   A 1 173 ? -10.14965 -17.14346 -25.50414 1.000 36.97599 ? 369 GLU   A C   1 
ATOM   1232 O O   . GLU   A 1 173 ? -11.25413 -16.77072 -25.10353 1.000 30.63317 ? 369 GLU   A O   1 
ATOM   1233 C CB  . GLU   A 1 173 ? -11.36438 -18.48272 -27.26478 1.000 41.91591 ? 369 GLU   A CB  1 
ATOM   1234 C CG  . GLU   A 1 173 ? -11.29370 -19.29117 -28.54896 1.000 47.58289 ? 369 GLU   A CG  1 
ATOM   1235 C CD  . GLU   A 1 173 ? -12.29850 -18.82636 -29.58358 1.000 65.24315 ? 369 GLU   A CD  1 
ATOM   1236 O OE1 . GLU   A 1 173 ? -12.20736 -17.65744 -30.01634 1.000 65.27226 ? 369 GLU   A OE1 1 
ATOM   1237 O OE2 . GLU   A 1 173 ? -13.17823 -19.62769 -29.96372 1.000 67.58319 ? 369 GLU   A OE2 1 
ATOM   1238 N N   . LEU   A 1 174 ? -9.01870  -16.81943 -24.88608 1.000 36.51373 ? 370 LEU   A N   1 
ATOM   1239 C CA  . LEU   A 1 174 ? -9.01357  -15.88051 -23.77629 1.000 29.63888 ? 370 LEU   A CA  1 
ATOM   1240 C C   . LEU   A 1 174 ? -9.10637  -14.45231 -24.29950 1.000 31.88393 ? 370 LEU   A C   1 
ATOM   1241 O O   . LEU   A 1 174 ? -8.69615  -14.15378 -25.42477 1.000 30.59749 ? 370 LEU   A O   1 
ATOM   1242 C CB  . LEU   A 1 174 ? -7.74637  -16.04586 -22.93555 1.000 26.58762 ? 370 LEU   A CB  1 
ATOM   1243 C CG  . LEU   A 1 174 ? -7.36217  -17.46575 -22.51107 1.000 31.28950 ? 370 LEU   A CG  1 
ATOM   1244 C CD1 . LEU   A 1 174 ? -6.08510  -17.44655 -21.68746 1.000 32.40570 ? 370 LEU   A CD1 1 
ATOM   1245 C CD2 . LEU   A 1 174 ? -8.48905  -18.12316 -21.73056 1.000 30.51914 ? 370 LEU   A CD2 1 
ATOM   1246 N N   . ASP   A 1 175 ? -9.66175  -13.56849 -23.47682 1.000 29.93060 ? 371 ASP   A N   1 
ATOM   1247 C CA  . ASP   A 1 175 ? -9.68571  -12.14423 -23.77274 1.000 32.43750 ? 371 ASP   A CA  1 
ATOM   1248 C C   . ASP   A 1 175 ? -8.71834  -11.41787 -22.84278 1.000 30.12720 ? 371 ASP   A C   1 
ATOM   1249 O O   . ASP   A 1 175 ? -8.05732  -12.02697 -21.99644 1.000 29.93194 ? 371 ASP   A O   1 
ATOM   1250 C CB  . ASP   A 1 175 ? -11.11127 -11.58245 -23.67483 1.000 33.76202 ? 371 ASP   A CB  1 
ATOM   1251 C CG  . ASP   A 1 175 ? -11.75551 -11.80314 -22.31239 1.000 35.24970 ? 371 ASP   A CG  1 
ATOM   1252 O OD1 . ASP   A 1 175 ? -11.04895 -11.79242 -21.28321 1.000 36.36878 ? 371 ASP   A OD1 1 
ATOM   1253 O OD2 . ASP   A 1 175 ? -12.99122 -11.98754 -22.27401 1.000 39.90441 ? 371 ASP   A OD2 1 
ATOM   1254 N N   . ASP   A 1 176 ? -8.64420  -10.09479 -23.00787 1.000 30.40588 ? 372 ASP   A N   1 
ATOM   1255 C CA  . ASP   A 1 176 ? -7.71205  -9.29959  -22.21490 1.000 29.99746 ? 372 ASP   A CA  1 
ATOM   1256 C C   . ASP   A 1 176 ? -8.00314  -9.40535  -20.72355 1.000 32.55465 ? 372 ASP   A C   1 
ATOM   1257 O O   . ASP   A 1 176 ? -7.08449  -9.29150  -19.90334 1.000 29.75076 ? 372 ASP   A O   1 
ATOM   1258 C CB  . ASP   A 1 176 ? -7.75858  -7.83851  -22.66252 1.000 33.57890 ? 372 ASP   A CB  1 
ATOM   1259 C CG  . ASP   A 1 176 ? -7.09238  -7.62034  -24.00754 1.000 39.06335 ? 372 ASP   A CG  1 
ATOM   1260 O OD1 . ASP   A 1 176 ? -5.93534  -8.05764  -24.17665 1.000 35.25424 ? 372 ASP   A OD1 1 
ATOM   1261 O OD2 . ASP   A 1 176 ? -7.72762  -7.01469  -24.89673 1.000 42.66049 ? 372 ASP   A OD2 1 
ATOM   1262 N N   . SER   A 1 177 ? -9.26647  -9.62120  -20.34999 1.000 26.93201 ? 373 SER   A N   1 
ATOM   1263 C CA  . SER   A 1 177 ? -9.58946  -9.77930  -18.93610 1.000 29.43593 ? 373 SER   A CA  1 
ATOM   1264 C C   . SER   A 1 177 ? -9.02261  -11.08410 -18.38637 1.000 30.29975 ? 373 SER   A C   1 
ATOM   1265 O O   . SER   A 1 177 ? -8.57103  -11.13383 -17.23612 1.000 33.92928 ? 373 SER   A O   1 
ATOM   1266 C CB  . SER   A 1 177 ? -11.10432 -9.70094  -18.72882 1.000 30.03478 ? 373 SER   A CB  1 
ATOM   1267 O OG  . SER   A 1 177 ? -11.74176 -10.93071 -19.02901 1.000 24.74119 ? 373 SER   A OG  1 
ATOM   1268 N N   . ASP   A 1 178 ? -9.02025  -12.14562 -19.19711 1.000 28.37505 ? 374 ASP   A N   1 
ATOM   1269 C CA  . ASP   A 1 178 ? -8.40486  -13.40089 -18.77369 1.000 30.07455 ? 374 ASP   A CA  1 
ATOM   1270 C C   . ASP   A 1 178 ? -6.88663  -13.28040 -18.73169 1.000 25.59726 ? 374 ASP   A C   1 
ATOM   1271 O O   . ASP   A 1 178 ? -6.24358  -13.71588 -17.76869 1.000 24.45392 ? 374 ASP   A O   1 
ATOM   1272 C CB  . ASP   A 1 178 ? -8.81276  -14.53705 -19.71342 1.000 27.40885 ? 374 ASP   A CB  1 
ATOM   1273 C CG  . ASP   A 1 178 ? -10.30916 -14.62783 -19.91023 1.000 33.59545 ? 374 ASP   A CG  1 
ATOM   1274 O OD1 . ASP   A 1 178 ? -11.04883 -14.49660 -18.91473 1.000 28.91737 ? 374 ASP   A OD1 1 
ATOM   1275 O OD2 . ASP   A 1 178 ? -10.74437 -14.83759 -21.06319 1.000 29.12396 ? 374 ASP   A OD2 1 
ATOM   1276 N N   . ILE   A 1 179 ? -6.29760  -12.69463 -19.77658 1.000 22.96386 ? 375 ILE   A N   1 
ATOM   1277 C CA  . ILE   A 1 179 ? -4.84331  -12.63998 -19.89110 1.000 25.55648 ? 375 ILE   A CA  1 
ATOM   1278 C C   . ILE   A 1 179 ? -4.24409  -11.78272 -18.78305 1.000 23.58845 ? 375 ILE   A C   1 
ATOM   1279 O O   . ILE   A 1 179 ? -3.17414  -12.09920 -18.24765 1.000 24.19537 ? 375 ILE   A O   1 
ATOM   1280 C CB  . ILE   A 1 179 ? -4.44561  -12.12980 -21.28929 1.000 30.41828 ? 375 ILE   A CB  1 
ATOM   1281 C CG1 . ILE   A 1 179 ? -4.95645  -13.08915 -22.36790 1.000 29.65768 ? 375 ILE   A CG1 1 
ATOM   1282 C CG2 . ILE   A 1 179 ? -2.93776  -11.94765 -21.39419 1.000 28.48233 ? 375 ILE   A CG2 1 
ATOM   1283 C CD1 . ILE   A 1 179 ? -4.87951  -12.52846 -23.77198 1.000 31.67835 ? 375 ILE   A CD1 1 
ATOM   1284 N N   . SER   A 1 180 ? -4.92381  -10.69211 -18.41445 1.000 23.51725 ? 376 SER   A N   1 
ATOM   1285 C CA  . SER   A 1 180 ? -4.40452  -9.81145  -17.37136 1.000 23.47820 ? 376 SER   A CA  1 
ATOM   1286 C C   . SER   A 1 180 ? -4.20378  -10.56243 -16.06193 1.000 25.05341 ? 376 SER   A C   1 
ATOM   1287 O O   . SER   A 1 180 ? -3.18228  -10.38775 -15.38716 1.000 20.80062 ? 376 SER   A O   1 
ATOM   1288 C CB  . SER   A 1 180 ? -5.34557  -8.62470  -17.16569 1.000 25.32050 ? 376 SER   A CB  1 
ATOM   1289 O OG  . SER   A 1 180 ? -6.56023  -9.02865  -16.56100 1.000 28.34565 ? 376 SER   A OG  1 
ATOM   1290 N N   . LEU   A 1 181 ? -5.16972  -11.40308 -15.68552 1.000 23.57841 ? 377 LEU   A N   1 
ATOM   1291 C CA  . LEU   A 1 181 ? -5.01872  -12.20575 -14.47773 1.000 19.61510 ? 377 LEU   A CA  1 
ATOM   1292 C C   . LEU   A 1 181 ? -3.98869  -13.31120 -14.66945 1.000 22.58899 ? 377 LEU   A C   1 
ATOM   1293 O O   . LEU   A 1 181 ? -3.28040  -13.66859 -13.72135 1.000 26.45916 ? 377 LEU   A O   1 
ATOM   1294 C CB  . LEU   A 1 181 ? -6.36935  -12.79442 -14.07174 1.000 22.65925 ? 377 LEU   A CB  1 
ATOM   1295 C CG  . LEU   A 1 181 ? -7.40972  -11.76717 -13.62333 1.000 26.20586 ? 377 LEU   A CG  1 
ATOM   1296 C CD1 . LEU   A 1 181 ? -8.78077  -12.41049 -13.48097 1.000 23.80433 ? 377 LEU   A CD1 1 
ATOM   1297 C CD2 . LEU   A 1 181 ? -6.97893  -11.11329 -12.31952 1.000 26.80058 ? 377 LEU   A CD2 1 
ATOM   1298 N N   . PHE   A 1 182 ? -3.89150  -13.85614 -15.88421 1.000 22.20944 ? 378 PHE   A N   1 
ATOM   1299 C CA  . PHE   A 1 182 ? -2.88969  -14.87654 -16.17766 1.000 21.64901 ? 378 PHE   A CA  1 
ATOM   1300 C C   . PHE   A 1 182 ? -1.48058  -14.31591 -16.01947 1.000 21.50472 ? 378 PHE   A C   1 
ATOM   1301 O O   . PHE   A 1 182 ? -0.60961  -14.94855 -15.40980 1.000 23.38372 ? 378 PHE   A O   1 
ATOM   1302 C CB  . PHE   A 1 182 ? -3.11319  -15.41215 -17.59410 1.000 21.74364 ? 378 PHE   A CB  1 
ATOM   1303 C CG  . PHE   A 1 182 ? -2.25272  -16.59322 -17.95363 1.000 25.48328 ? 378 PHE   A CG  1 
ATOM   1304 C CD1 . PHE   A 1 182 ? -2.47144  -17.83284 -17.37492 1.000 26.35141 ? 378 PHE   A CD1 1 
ATOM   1305 C CD2 . PHE   A 1 182 ? -1.24568  -16.46895 -18.89648 1.000 25.15493 ? 378 PHE   A CD2 1 
ATOM   1306 C CE1 . PHE   A 1 182 ? -1.68805  -18.92289 -17.71680 1.000 31.45960 ? 378 PHE   A CE1 1 
ATOM   1307 C CE2 . PHE   A 1 182 ? -0.45892  -17.55546 -19.24409 1.000 26.23922 ? 378 PHE   A CE2 1 
ATOM   1308 C CZ  . PHE   A 1 182 ? -0.67955  -18.78276 -18.65151 1.000 27.37734 ? 378 PHE   A CZ  1 
ATOM   1309 N N   . VAL   A 1 183 ? -1.24383  -13.11711 -16.55649 1.000 21.72606 ? 379 VAL   A N   1 
ATOM   1310 C CA  . VAL   A 1 183 ? 0.06953   -12.48929 -16.44174 1.000 25.09659 ? 379 VAL   A CA  1 
ATOM   1311 C C   . VAL   A 1 183 ? 0.37820   -12.14864 -14.98798 1.000 23.82934 ? 379 VAL   A C   1 
ATOM   1312 O O   . VAL   A 1 183 ? 1.51543   -12.30789 -14.52686 1.000 27.33273 ? 379 VAL   A O   1 
ATOM   1313 C CB  . VAL   A 1 183 ? 0.14095   -11.24723 -17.34867 1.000 28.24719 ? 379 VAL   A CB  1 
ATOM   1314 C CG1 . VAL   A 1 183 ? 1.41399   -10.45676 -17.08658 1.000 28.07337 ? 379 VAL   A CG1 1 
ATOM   1315 C CG2 . VAL   A 1 183 ? 0.05508   -11.65925 -18.81032 1.000 25.49387 ? 379 VAL   A CG2 1 
ATOM   1316 N N   . ALA   A 1 184 ? -0.62604  -11.68464 -14.23946 1.000 25.08790 ? 380 ALA   A N   1 
ATOM   1317 C CA  . ALA   A 1 184 ? -0.41626  -11.40171 -12.82257 1.000 23.06037 ? 380 ALA   A CA  1 
ATOM   1318 C C   . ALA   A 1 184 ? -0.00539  -12.65821 -12.06328 1.000 23.80549 ? 380 ALA   A C   1 
ATOM   1319 O O   . ALA   A 1 184 ? 0.88068   -12.61014 -11.20154 1.000 23.58062 ? 380 ALA   A O   1 
ATOM   1320 C CB  . ALA   A 1 184 ? -1.67949  -10.79320 -12.21318 1.000 26.27221 ? 380 ALA   A CB  1 
ATOM   1321 N N   . ALA   A 1 185 ? -0.63504  -13.79528 -12.37224 1.000 22.51047 ? 381 ALA   A N   1 
ATOM   1322 C CA  . ALA   A 1 185 ? -0.26604  -15.04470 -11.71516 1.000 23.14118 ? 381 ALA   A CA  1 
ATOM   1323 C C   . ALA   A 1 185 ? 1.14167   -15.48338 -12.09535 1.000 26.97689 ? 381 ALA   A C   1 
ATOM   1324 O O   . ALA   A 1 185 ? 1.83956   -16.09751 -11.28049 1.000 27.17027 ? 381 ALA   A O   1 
ATOM   1325 C CB  . ALA   A 1 185 ? -1.27568  -16.13951 -12.05942 1.000 21.27254 ? 381 ALA   A CB  1 
ATOM   1326 N N   . ILE   A 1 186 ? 1.57418   -15.17479 -13.31889 1.000 26.80292 ? 382 ILE   A N   1 
ATOM   1327 C CA  . ILE   A 1 186 ? 2.92484   -15.52490 -13.74878 1.000 26.55138 ? 382 ILE   A CA  1 
ATOM   1328 C C   . ILE   A 1 186 ? 3.95858   -14.74746 -12.94228 1.000 30.99654 ? 382 ILE   A C   1 
ATOM   1329 O O   . ILE   A 1 186 ? 4.94642   -15.31263 -12.45726 1.000 28.83755 ? 382 ILE   A O   1 
ATOM   1330 C CB  . ILE   A 1 186 ? 3.08262   -15.27308 -15.25920 1.000 21.63711 ? 382 ILE   A CB  1 
ATOM   1331 C CG1 . ILE   A 1 186 ? 2.43915   -16.40446 -16.06085 1.000 24.14150 ? 382 ILE   A CG1 1 
ATOM   1332 C CG2 . ILE   A 1 186 ? 4.55292   -15.11353 -15.63386 1.000 26.14461 ? 382 ILE   A CG2 1 
ATOM   1333 C CD1 . ILE   A 1 186 ? 2.17897   -16.04405 -17.50485 1.000 24.42166 ? 382 ILE   A CD1 1 
ATOM   1334 N N   . ILE   A 1 187 ? 3.74141   -13.44035 -12.78193 1.000 25.44794 ? 383 ILE   A N   1 
ATOM   1335 C CA  . ILE   A 1 187 ? 4.70410   -12.59995 -12.07506 1.000 27.45413 ? 383 ILE   A CA  1 
ATOM   1336 C C   . ILE   A 1 187 ? 4.76066   -12.97511 -10.59889 1.000 35.41369 ? 383 ILE   A C   1 
ATOM   1337 O O   . ILE   A 1 187 ? 5.84243   -13.15200 -10.02562 1.000 28.48958 ? 383 ILE   A O   1 
ATOM   1338 C CB  . ILE   A 1 187 ? 4.35516   -11.11290 -12.26460 1.000 32.58280 ? 383 ILE   A CB  1 
ATOM   1339 C CG1 . ILE   A 1 187 ? 4.61774   -10.68153 -13.70862 1.000 30.85596 ? 383 ILE   A CG1 1 
ATOM   1340 C CG2 . ILE   A 1 187 ? 5.14918   -10.24841 -11.29583 1.000 33.45805 ? 383 ILE   A CG2 1 
ATOM   1341 C CD1 . ILE   A 1 187 ? 3.89945   -9.40644  -14.10254 1.000 28.72982 ? 383 ILE   A CD1 1 
ATOM   1342 N N   . CYS   A 1 188 ? 3.59686   -13.09912 -9.96033  1.000 29.58240 ? 384 CYS   A N   1 
ATOM   1343 C CA  . CYS   A 1 188 ? 3.52148   -13.43366 -8.53865  1.000 33.05171 ? 384 CYS   A CA  1 
ATOM   1344 C C   . CYS   A 1 188 ? 3.59697   -14.95226 -8.37632  1.000 35.05870 ? 384 CYS   A C   1 
ATOM   1345 O O   . CYS   A 1 188 ? 2.61788   -15.63743 -8.07717  1.000 44.37280 ? 384 CYS   A O   1 
ATOM   1346 C CB  . CYS   A 1 188 ? 2.25009   -12.86319 -7.92735  1.000 34.45733 ? 384 CYS   A CB  1 
ATOM   1347 S SG  . CYS   A 1 188 ? 2.12959   -11.06747 -8.05047  1.000 39.39738 ? 384 CYS   A SG  1 
ATOM   1348 N N   . CYS   A 1 189 ? 4.80073   -15.47781 -8.58742  1.000 36.04702 ? 385 CYS   A N   1 
ATOM   1349 C CA  A CYS   A 1 189 ? 5.06608   -16.90786 -8.50486  0.698 33.68402 ? 385 CYS   A CA  1 
ATOM   1350 C CA  B CYS   A 1 189 ? 5.06888   -16.90910 -8.50634  0.302 34.23507 ? 385 CYS   A CA  1 
ATOM   1351 C C   . CYS   A 1 189 ? 6.05292   -17.16222 -7.37440  1.000 38.06497 ? 385 CYS   A C   1 
ATOM   1352 O O   . CYS   A 1 189 ? 7.19174   -16.68571 -7.42111  1.000 31.91917 ? 385 CYS   A O   1 
ATOM   1353 C CB  A CYS   A 1 189 ? 5.61347   -17.43905 -9.83061  0.698 35.18558 ? 385 CYS   A CB  1 
ATOM   1354 C CB  B CYS   A 1 189 ? 5.62672   -17.44458 -9.82767  0.302 34.75158 ? 385 CYS   A CB  1 
ATOM   1355 S SG  A CYS   A 1 189 ? 5.96507   -19.20802 -9.83037  0.698 34.82989 ? 385 CYS   A SG  1 
ATOM   1356 S SG  B CYS   A 1 189 ? 4.39572   -18.15603 -10.94664 0.302 32.77658 ? 385 CYS   A SG  1 
ATOM   1357 N N   . GLY   A 1 190 ? 5.61623   -17.91302 -6.36582  1.000 34.15689 ? 386 GLY   A N   1 
ATOM   1358 C CA  . GLY   A 1 190 ? 6.45913   -18.25045 -5.23971  1.000 39.61868 ? 386 GLY   A CA  1 
ATOM   1359 C C   . GLY   A 1 190 ? 7.48773   -19.32577 -5.49783  1.000 44.22051 ? 386 GLY   A C   1 
ATOM   1360 O O   . GLY   A 1 190 ? 8.18154   -19.74221 -4.56689  1.000 43.31875 ? 386 GLY   A O   1 
ATOM   1361 N N   . ASP   A 1 191 ? 7.61204   -19.78858 -6.74005  1.000 37.06597 ? 387 ASP   A N   1 
ATOM   1362 C CA  . ASP   A 1 191 ? 8.54533   -20.84492 -7.10337  1.000 43.34111 ? 387 ASP   A CA  1 
ATOM   1363 C C   . ASP   A 1 191 ? 9.86295   -20.31567 -7.65331  1.000 42.88598 ? 387 ASP   A C   1 
ATOM   1364 O O   . ASP   A 1 191 ? 10.74303  -21.11538 -7.98678  1.000 44.62856 ? 387 ASP   A O   1 
ATOM   1365 C CB  . ASP   A 1 191 ? 7.90045   -21.77911 -8.13352  1.000 46.20127 ? 387 ASP   A CB  1 
ATOM   1366 C CG  . ASP   A 1 191 ? 8.17252   -23.24111 -7.84727  1.000 60.85110 ? 387 ASP   A CG  1 
ATOM   1367 O OD1 . ASP   A 1 191 ? 8.98643   -23.53173 -6.94535  1.000 66.61260 ? 387 ASP   A OD1 1 
ATOM   1368 O OD2 . ASP   A 1 191 ? 7.57062   -24.10059 -8.52532  1.000 69.19295 ? 387 ASP   A OD2 1 
ATOM   1369 N N   . ARG   A 1 192 ? 10.02126  -18.99974 -7.75558  1.000 37.03665 ? 388 ARG   A N   1 
ATOM   1370 C CA  . ARG   A 1 192 ? 11.21762  -18.44473 -8.37033  1.000 38.21237 ? 388 ARG   A CA  1 
ATOM   1371 C C   . ARG   A 1 192 ? 12.43335  -18.68732 -7.47787  1.000 41.72769 ? 388 ARG   A C   1 
ATOM   1372 O O   . ARG   A 1 192 ? 12.33695  -18.57908 -6.25113  1.000 37.83196 ? 388 ARG   A O   1 
ATOM   1373 C CB  . ARG   A 1 192 ? 11.04651  -16.94786 -8.62907  1.000 34.10784 ? 388 ARG   A CB  1 
ATOM   1374 C CG  . ARG   A 1 192 ? 9.79427   -16.58868 -9.41472  1.000 32.25191 ? 388 ARG   A CG  1 
ATOM   1375 C CD  . ARG   A 1 192 ? 9.65511   -17.44499 -10.66335 1.000 33.43838 ? 388 ARG   A CD  1 
ATOM   1376 N NE  . ARG   A 1 192 ? 8.62423   -16.94158 -11.56367 1.000 29.16412 ? 388 ARG   A NE  1 
ATOM   1377 C CZ  . ARG   A 1 192 ? 8.28923   -17.51393 -12.71199 1.000 32.10544 ? 388 ARG   A CZ  1 
ATOM   1378 N NH1 . ARG   A 1 192 ? 8.89159   -18.61209 -13.13873 1.000 29.17941 ? 388 ARG   A NH1 1 
ATOM   1379 N NH2 . ARG   A 1 192 ? 7.32589   -16.97092 -13.45120 1.000 32.04160 ? 388 ARG   A NH2 1 
ATOM   1380 N N   . PRO   A 1 193 ? 13.58485  -19.01873 -8.06043  1.000 41.28475 ? 389 PRO   A N   1 
ATOM   1381 C CA  . PRO   A 1 193 ? 14.77057  -19.29782 -7.24145  1.000 40.37325 ? 389 PRO   A CA  1 
ATOM   1382 C C   . PRO   A 1 193 ? 15.28139  -18.04214 -6.55270  1.000 36.34509 ? 389 PRO   A C   1 
ATOM   1383 O O   . PRO   A 1 193 ? 15.34320  -16.96409 -7.14793  1.000 40.78140 ? 389 PRO   A O   1 
ATOM   1384 C CB  . PRO   A 1 193 ? 15.79177  -19.83102 -8.25642  1.000 39.36858 ? 389 PRO   A CB  1 
ATOM   1385 C CG  . PRO   A 1 193 ? 15.00394  -20.13932 -9.50196  1.000 39.69984 ? 389 PRO   A CG  1 
ATOM   1386 C CD  . PRO   A 1 193 ? 13.84680  -19.19815 -9.49683  1.000 39.11512 ? 389 PRO   A CD  1 
ATOM   1387 N N   . GLY   A 1 194 ? 15.65145  -18.19363 -5.28474  1.000 37.85153 ? 390 GLY   A N   1 
ATOM   1388 C CA  . GLY   A 1 194 ? 16.20159  -17.09794 -4.51592  1.000 40.44793 ? 390 GLY   A CA  1 
ATOM   1389 C C   . GLY   A 1 194 ? 15.18892  -16.18858 -3.85988  1.000 38.26468 ? 390 GLY   A C   1 
ATOM   1390 O O   . GLY   A 1 194 ? 15.57309  -15.12517 -3.35757  1.000 37.65596 ? 390 GLY   A O   1 
ATOM   1391 N N   . LEU   A 1 195 ? 13.91301  -16.56452 -3.84768  1.000 39.01259 ? 391 LEU   A N   1 
ATOM   1392 C CA  . LEU   A 1 195 ? 12.89659  -15.73748 -3.21342  1.000 43.29851 ? 391 LEU   A CA  1 
ATOM   1393 C C   . LEU   A 1 195 ? 13.04506  -15.77961 -1.69768  1.000 39.96004 ? 391 LEU   A C   1 
ATOM   1394 O O   . LEU   A 1 195 ? 13.38303  -16.81557 -1.11783  1.000 44.81880 ? 391 LEU   A O   1 
ATOM   1395 C CB  . LEU   A 1 195 ? 11.50039  -16.20860 -3.61650  1.000 35.91288 ? 391 LEU   A CB  1 
ATOM   1396 C CG  . LEU   A 1 195 ? 10.94417  -15.66789 -4.93400  1.000 38.34384 ? 391 LEU   A CG  1 
ATOM   1397 C CD1 . LEU   A 1 195 ? 9.52309   -16.16271 -5.14889  1.000 39.15272 ? 391 LEU   A CD1 1 
ATOM   1398 C CD2 . LEU   A 1 195 ? 10.99718  -14.14864 -4.96143  1.000 33.35400 ? 391 LEU   A CD2 1 
ATOM   1399 N N   . LEU   A 1 196 ? 12.78747  -14.64148 -1.05455  1.000 45.45420 ? 392 LEU   A N   1 
ATOM   1400 C CA  . LEU   A 1 196 ? 12.88958  -14.54290 0.40700   1.000 40.61684 ? 392 LEU   A CA  1 
ATOM   1401 C C   . LEU   A 1 196 ? 11.53671  -14.81826 1.05597   1.000 42.27096 ? 392 LEU   A C   1 
ATOM   1402 O O   . LEU   A 1 196 ? 11.36562  -15.81812 1.75941   1.000 38.71337 ? 392 LEU   A O   1 
ATOM   1403 C CB  . LEU   A 1 196 ? 13.42888  -13.16915 0.80889   1.000 42.04345 ? 392 LEU   A CB  1 
ATOM   1404 C CG  . LEU   A 1 196 ? 14.86113  -12.85524 0.37885   1.000 36.61251 ? 392 LEU   A CG  1 
ATOM   1405 C CD1 . LEU   A 1 196 ? 15.24996  -11.45258 0.81478   1.000 46.21261 ? 392 LEU   A CD1 1 
ATOM   1406 C CD2 . LEU   A 1 196 ? 15.82833  -13.88734 0.94154   1.000 36.63683 ? 392 LEU   A CD2 1 
ATOM   1407 N N   . ASN   A 1 197 ? 10.56631  -13.93345 0.82815   1.000 41.84931 ? 393 ASN   A N   1 
ATOM   1408 C CA  . ASN   A 1 197 ? 9.23754   -14.07863 1.42080   1.000 43.61495 ? 393 ASN   A CA  1 
ATOM   1409 C C   . ASN   A 1 197 ? 8.41342   -15.04401 0.56794   1.000 42.22689 ? 393 ASN   A C   1 
ATOM   1410 O O   . ASN   A 1 197 ? 7.49330   -14.66763 -0.16075  1.000 45.93689 ? 393 ASN   A O   1 
ATOM   1411 C CB  . ASN   A 1 197 ? 8.56130   -12.72220 1.55585   1.000 47.68750 ? 393 ASN   A CB  1 
ATOM   1412 C CG  . ASN   A 1 197 ? 7.60674   -12.66471 2.73095   1.000 48.17808 ? 393 ASN   A CG  1 
ATOM   1413 O OD1 . ASN   A 1 197 ? 7.27777   -13.69003 3.32837   1.000 46.57809 ? 393 ASN   A OD1 1 
ATOM   1414 N ND2 . ASN   A 1 197 ? 7.15222   -11.46282 3.06672   1.000 56.70223 ? 393 ASN   A ND2 1 
ATOM   1415 N N   . VAL   A 1 198 ? 8.76699   -16.32622 0.67749   1.000 38.50760 ? 394 VAL   A N   1 
ATOM   1416 C CA  . VAL   A 1 198 ? 8.12210   -17.34776 -0.14128  1.000 45.11138 ? 394 VAL   A CA  1 
ATOM   1417 C C   . VAL   A 1 198 ? 6.67810   -17.55639 0.29905   1.000 47.49506 ? 394 VAL   A C   1 
ATOM   1418 O O   . VAL   A 1 198 ? 5.77056   -17.66661 -0.53478  1.000 42.40124 ? 394 VAL   A O   1 
ATOM   1419 C CB  . VAL   A 1 198 ? 8.93054   -18.65759 -0.08681  1.000 42.52954 ? 394 VAL   A CB  1 
ATOM   1420 C CG1 . VAL   A 1 198 ? 8.06329   -19.84576 -0.48061  1.000 43.06547 ? 394 VAL   A CG1 1 
ATOM   1421 C CG2 . VAL   A 1 198 ? 10.15999  -18.56152 -0.98047  1.000 46.38417 ? 394 VAL   A CG2 1 
ATOM   1422 N N   . GLY   A 1 199 ? 6.43927   -17.59977 1.61134   1.000 44.34681 ? 395 GLY   A N   1 
ATOM   1423 C CA  . GLY   A 1 199 ? 5.09572   -17.86307 2.10101   1.000 44.17771 ? 395 GLY   A CA  1 
ATOM   1424 C C   . GLY   A 1 199 ? 4.11743   -16.74778 1.78418   1.000 44.85547 ? 395 GLY   A C   1 
ATOM   1425 O O   . GLY   A 1 199 ? 2.93875   -17.00161 1.51961   1.000 42.35604 ? 395 GLY   A O   1 
ATOM   1426 N N   . HIS   A 1 200 ? 4.58704   -15.49942 1.80561   1.000 38.62647 ? 396 HIS   A N   1 
ATOM   1427 C CA  . HIS   A 1 200 ? 3.70006   -14.37873 1.51573   1.000 40.16690 ? 396 HIS   A CA  1 
ATOM   1428 C C   . HIS   A 1 200 ? 3.44872   -14.23743 0.01891   1.000 42.37053 ? 396 HIS   A C   1 
ATOM   1429 O O   . HIS   A 1 200 ? 2.33203   -13.90588 -0.39477  1.000 37.45645 ? 396 HIS   A O   1 
ATOM   1430 C CB  . HIS   A 1 200 ? 4.28006   -13.08618 2.09014   1.000 42.72638 ? 396 HIS   A CB  1 
ATOM   1431 C CG  . HIS   A 1 200 ? 3.53837   -11.85325 1.67671   1.000 46.40986 ? 396 HIS   A CG  1 
ATOM   1432 N ND1 . HIS   A 1 200 ? 4.12559   -10.83954 0.95118   1.000 51.22584 ? 396 HIS   A ND1 1 
ATOM   1433 C CD2 . HIS   A 1 200 ? 2.25738   -11.46952 1.88951   1.000 46.10566 ? 396 HIS   A CD2 1 
ATOM   1434 C CE1 . HIS   A 1 200 ? 3.23847   -9.88531  0.73276   1.000 53.36509 ? 396 HIS   A CE1 1 
ATOM   1435 N NE2 . HIS   A 1 200 ? 2.09662   -10.24286 1.29193   1.000 53.57289 ? 396 HIS   A NE2 1 
ATOM   1436 N N   . ILE   A 1 201 ? 4.46934   -14.48341 -0.80650  1.000 39.32698 ? 397 ILE   A N   1 
ATOM   1437 C CA  . ILE   A 1 201 ? 4.26898   -14.45836 -2.25221  1.000 36.09453 ? 397 ILE   A CA  1 
ATOM   1438 C C   . ILE   A 1 201 ? 3.34666   -15.59412 -2.67745  1.000 37.80640 ? 397 ILE   A C   1 
ATOM   1439 O O   . ILE   A 1 201 ? 2.48821   -15.42150 -3.55205  1.000 36.18063 ? 397 ILE   A O   1 
ATOM   1440 C CB  . ILE   A 1 201 ? 5.62366   -14.51292 -2.98332  1.000 35.97005 ? 397 ILE   A CB  1 
ATOM   1441 C CG1 . ILE   A 1 201 ? 6.39493   -13.20986 -2.76855  1.000 37.08318 ? 397 ILE   A CG1 1 
ATOM   1442 C CG2 . ILE   A 1 201 ? 5.42630   -14.75963 -4.47167  1.000 32.91384 ? 397 ILE   A CG2 1 
ATOM   1443 C CD1 . ILE   A 1 201 ? 7.82400   -13.26014 -3.25594  1.000 39.42662 ? 397 ILE   A CD1 1 
ATOM   1444 N N   . GLU   A 1 202 ? 3.49949   -16.76855 -2.05834  1.000 33.97485 ? 398 GLU   A N   1 
ATOM   1445 C CA  . GLU   A 1 202 ? 2.56352   -17.86191 -2.29939  1.000 39.06503 ? 398 GLU   A CA  1 
ATOM   1446 C C   . GLU   A 1 202 ? 1.14176   -17.45737 -1.92840  1.000 37.56953 ? 398 GLU   A C   1 
ATOM   1447 O O   . GLU   A 1 202 ? 0.18081   -17.84739 -2.60205  1.000 39.59491 ? 398 GLU   A O   1 
ATOM   1448 C CB  . GLU   A 1 202 ? 2.99140   -19.10186 -1.51310  1.000 40.13261 ? 398 GLU   A CB  1 
ATOM   1449 C CG  . GLU   A 1 202 ? 4.07040   -19.93074 -2.19192  1.000 44.79451 ? 398 GLU   A CG  1 
ATOM   1450 C CD  . GLU   A 1 202 ? 4.44492   -21.16570 -1.39421  1.000 56.52931 ? 398 GLU   A CD  1 
ATOM   1451 O OE1 . GLU   A 1 202 ? 5.24144   -21.98379 -1.90090  1.000 54.44797 ? 398 GLU   A OE1 1 
ATOM   1452 O OE2 . GLU   A 1 202 ? 3.94396   -21.31809 -0.25979  1.000 53.11396 ? 398 GLU   A OE2 1 
ATOM   1453 N N   . LYS   A 1 203 ? 0.98871   -16.67206 -0.85864  1.000 41.37844 ? 399 LYS   A N   1 
ATOM   1454 C CA  . LYS   A 1 203 ? -0.33184  -16.16852 -0.49484  1.000 43.16476 ? 399 LYS   A CA  1 
ATOM   1455 C C   . LYS   A 1 203 ? -0.84793  -15.18150 -1.53373  1.000 39.86212 ? 399 LYS   A C   1 
ATOM   1456 O O   . LYS   A 1 203 ? -2.03837  -15.19055 -1.86913  1.000 32.09241 ? 399 LYS   A O   1 
ATOM   1457 C CB  . LYS   A 1 203 ? -0.28541  -15.51788 0.88729   1.000 40.14260 ? 399 LYS   A CB  1 
ATOM   1458 C CG  . LYS   A 1 203 ? -1.08226  -16.25805 1.94956   1.000 47.97463 ? 399 LYS   A CG  1 
ATOM   1459 C CD  . LYS   A 1 203 ? -0.41027  -17.56556 2.33200   1.000 48.59184 ? 399 LYS   A CD  1 
ATOM   1460 C CE  . LYS   A 1 203 ? -1.31544  -18.41565 3.20890   1.000 57.56510 ? 399 LYS   A CE  1 
ATOM   1461 N NZ  . LYS   A 1 203 ? -0.53610  -19.20749 4.19968   1.000 50.93934 ? 399 LYS   A NZ  1 
ATOM   1462 N N   . MET   A 1 204 ? 0.03220   -14.31918 -2.04960  1.000 31.34745 ? 400 MET   A N   1 
ATOM   1463 C CA  . MET   A 1 204 ? -0.36262  -13.41528 -3.12486  1.000 36.19588 ? 400 MET   A CA  1 
ATOM   1464 C C   . MET   A 1 204 ? -0.78226  -14.19306 -4.36376  1.000 31.10525 ? 400 MET   A C   1 
ATOM   1465 O O   . MET   A 1 204 ? -1.79077  -13.86594 -5.00060  1.000 33.65371 ? 400 MET   A O   1 
ATOM   1466 C CB  . MET   A 1 204 ? 0.78336   -12.46151 -3.45969  1.000 37.25253 ? 400 MET   A CB  1 
ATOM   1467 C CG  . MET   A 1 204 ? 1.03180   -11.38742 -2.41959  1.000 42.06866 ? 400 MET   A CG  1 
ATOM   1468 S SD  . MET   A 1 204 ? 2.40412   -10.31184 -2.87941  1.000 48.02019 ? 400 MET   A SD  1 
ATOM   1469 C CE  . MET   A 1 204 ? 1.90200   -9.79293  -4.51874  1.000 34.96462 ? 400 MET   A CE  1 
ATOM   1470 N N   . GLN   A 1 205 ? -0.01744  -15.22889 -4.71875  1.000 34.13036 ? 401 GLN   A N   1 
ATOM   1471 C CA  . GLN   A 1 205 ? -0.37750  -16.06513 -5.85841  1.000 37.54975 ? 401 GLN   A CA  1 
ATOM   1472 C C   . GLN   A 1 205 ? -1.71488  -16.75606 -5.63356  1.000 34.69492 ? 401 GLN   A C   1 
ATOM   1473 O O   . GLN   A 1 205 ? -2.52524  -16.87155 -6.56037  1.000 33.83638 ? 401 GLN   A O   1 
ATOM   1474 C CB  . GLN   A 1 205 ? 0.71784   -17.09883 -6.11557  1.000 35.24941 ? 401 GLN   A CB  1 
ATOM   1475 C CG  . GLN   A 1 205 ? 0.37225   -18.11219 -7.19333  1.000 38.51362 ? 401 GLN   A CG  1 
ATOM   1476 C CD  . GLN   A 1 205 ? 1.59867   -18.77312 -7.78752  1.000 38.29452 ? 401 GLN   A CD  1 
ATOM   1477 O OE1 . GLN   A 1 205 ? 1.89784   -18.60192 -8.96952  1.000 44.48109 ? 401 GLN   A OE1 1 
ATOM   1478 N NE2 . GLN   A 1 205 ? 2.31848   -19.53221 -6.96857  1.000 42.87362 ? 401 GLN   A NE2 1 
ATOM   1479 N N   . GLU   A 1 206 ? -1.96080  -17.22469 -4.40680  1.000 36.06232 ? 402 GLU   A N   1 
ATOM   1480 C CA  . GLU   A 1 206 ? -3.22228  -17.89306 -4.10430  1.000 33.83655 ? 402 GLU   A CA  1 
ATOM   1481 C C   . GLU   A 1 206 ? -4.40866  -16.97226 -4.35675  1.000 31.82747 ? 402 GLU   A C   1 
ATOM   1482 O O   . GLU   A 1 206 ? -5.42423  -17.39688 -4.91978  1.000 30.26271 ? 402 GLU   A O   1 
ATOM   1483 C CB  . GLU   A 1 206 ? -3.22191  -18.38170 -2.65544  1.000 41.76269 ? 402 GLU   A CB  1 
ATOM   1484 C CG  . GLU   A 1 206 ? -3.49657  -19.86859 -2.49555  1.000 52.21932 ? 402 GLU   A CG  1 
ATOM   1485 C CD  . GLU   A 1 206 ? -3.88428  -20.24043 -1.07524  1.000 56.46704 ? 402 GLU   A CD  1 
ATOM   1486 O OE1 . GLU   A 1 206 ? -4.74417  -21.13071 -0.90622  1.000 50.83585 ? 402 GLU   A OE1 1 
ATOM   1487 O OE2 . GLU   A 1 206 ? -3.33080  -19.64175 -0.12797  1.000 51.12561 ? 402 GLU   A OE2 1 
ATOM   1488 N N   . GLY   A 1 207 ? -4.29659  -15.70569 -3.95319  1.000 28.03264 ? 403 GLY   A N   1 
ATOM   1489 C CA  . GLY   A 1 207 ? -5.38134  -14.76787 -4.19056  1.000 30.86361 ? 403 GLY   A CA  1 
ATOM   1490 C C   . GLY   A 1 207 ? -5.60797  -14.49312 -5.66501  1.000 32.26002 ? 403 GLY   A C   1 
ATOM   1491 O O   . GLY   A 1 207 ? -6.75042  -14.46993 -6.13221  1.000 31.69199 ? 403 GLY   A O   1 
ATOM   1492 N N   . ILE   A 1 208 ? -4.52626  -14.28448 -6.41902  1.000 30.31142 ? 404 ILE   A N   1 
ATOM   1493 C CA  . ILE   A 1 208 ? -4.65946  -14.01901 -7.84827  1.000 26.84660 ? 404 ILE   A CA  1 
ATOM   1494 C C   . ILE   A 1 208 ? -5.20617  -15.24405 -8.57112  1.000 26.98292 ? 404 ILE   A C   1 
ATOM   1495 O O   . ILE   A 1 208 ? -6.10390  -15.13450 -9.41585  1.000 27.99094 ? 404 ILE   A O   1 
ATOM   1496 C CB  . ILE   A 1 208 ? -3.30902  -13.56606 -8.43465  1.000 28.82681 ? 404 ILE   A CB  1 
ATOM   1497 C CG1 . ILE   A 1 208 ? -2.94391  -12.17327 -7.91727  1.000 32.77621 ? 404 ILE   A CG1 1 
ATOM   1498 C CG2 . ILE   A 1 208 ? -3.35667  -13.56481 -9.95498  1.000 29.89076 ? 404 ILE   A CG2 1 
ATOM   1499 C CD1 . ILE   A 1 208 ? -1.48510  -11.81448 -8.09929  1.000 31.57634 ? 404 ILE   A CD1 1 
ATOM   1500 N N   . VAL   A 1 209 ? -4.68578  -16.42918 -8.24241  1.000 32.08195 ? 405 VAL   A N   1 
ATOM   1501 C CA  . VAL   A 1 209 ? -5.13412  -17.65493 -8.89884  1.000 32.51682 ? 405 VAL   A CA  1 
ATOM   1502 C C   . VAL   A 1 209 ? -6.59666  -17.93314 -8.57392  1.000 33.56539 ? 405 VAL   A C   1 
ATOM   1503 O O   . VAL   A 1 209 ? -7.37837  -18.33071 -9.44729  1.000 30.15731 ? 405 VAL   A O   1 
ATOM   1504 C CB  . VAL   A 1 209 ? -4.22542  -18.83232 -8.49763  1.000 32.14832 ? 405 VAL   A CB  1 
ATOM   1505 C CG1 . VAL   A 1 209 ? -4.92452  -20.16097 -8.73617  1.000 37.80337 ? 405 VAL   A CG1 1 
ATOM   1506 C CG2 . VAL   A 1 209 ? -2.91110  -18.76907 -9.26219  1.000 30.93220 ? 405 VAL   A CG2 1 
ATOM   1507 N N   . HIS   A 1 210 ? -6.99208  -17.72473 -7.31628  1.000 30.66357 ? 406 HIS   A N   1 
ATOM   1508 C CA  . HIS   A 1 210 ? -8.38593  -17.93597 -6.93878  1.000 35.74331 ? 406 HIS   A CA  1 
ATOM   1509 C C   . HIS   A 1 210 ? -9.30538  -16.95898 -7.66158  1.000 31.35492 ? 406 HIS   A C   1 
ATOM   1510 O O   . HIS   A 1 210 ? -10.38750 -17.33895 -8.12465  1.000 30.23046 ? 406 HIS   A O   1 
ATOM   1511 C CB  . HIS   A 1 210 ? -8.54289  -17.80620 -5.42372  1.000 34.62455 ? 406 HIS   A CB  1 
ATOM   1512 C CG  . HIS   A 1 210 ? -9.96625  -17.74752 -4.96626  1.000 38.72427 ? 406 HIS   A CG  1 
ATOM   1513 N ND1 . HIS   A 1 210 ? -10.73313 -18.87678 -4.77499  1.000 51.65689 ? 406 HIS   A ND1 1 
ATOM   1514 C CD2 . HIS   A 1 210 ? -10.76205 -16.69578 -4.66014  1.000 42.75168 ? 406 HIS   A CD2 1 
ATOM   1515 C CE1 . HIS   A 1 210 ? -11.94048 -18.52328 -4.37188  1.000 47.33945 ? 406 HIS   A CE1 1 
ATOM   1516 N NE2 . HIS   A 1 210 ? -11.98386 -17.20552 -4.29335  1.000 47.84627 ? 406 HIS   A NE2 1 
ATOM   1517 N N   . VAL   A 1 211 ? -8.88924  -15.69557 -7.77107  1.000 27.56467 ? 407 VAL   A N   1 
ATOM   1518 C CA  . VAL   A 1 211 ? -9.67492  -14.71390 -8.51171  1.000 29.89189 ? 407 VAL   A CA  1 
ATOM   1519 C C   . VAL   A 1 211 ? -9.72027  -15.07624 -9.99205  1.000 30.79755 ? 407 VAL   A C   1 
ATOM   1520 O O   . VAL   A 1 211 ? -10.75375 -14.91614 -10.65413 1.000 31.65810 ? 407 VAL   A O   1 
ATOM   1521 C CB  . VAL   A 1 211 ? -9.10698  -13.30059 -8.28049  1.000 33.49977 ? 407 VAL   A CB  1 
ATOM   1522 C CG1 . VAL   A 1 211 ? -9.54771  -12.35162 -9.37978  1.000 33.41835 ? 407 VAL   A CG1 1 
ATOM   1523 C CG2 . VAL   A 1 211 ? -9.53620  -12.77491 -6.91908  1.000 37.70916 ? 407 VAL   A CG2 1 
ATOM   1524 N N   . LEU   A 1 212 ? -8.60776  -15.58138 -10.53284 1.000 29.96486 ? 408 LEU   A N   1 
ATOM   1525 C CA  . LEU   A 1 212 ? -8.60588  -16.04310 -11.91766 1.000 29.35046 ? 408 LEU   A CA  1 
ATOM   1526 C C   . LEU   A 1 212 ? -9.53258  -17.23932 -12.09650 1.000 27.35939 ? 408 LEU   A C   1 
ATOM   1527 O O   . LEU   A 1 212 ? -10.19821 -17.36911 -13.13022 1.000 26.80962 ? 408 LEU   A O   1 
ATOM   1528 C CB  . LEU   A 1 212 ? -7.18166  -16.39214 -12.35589 1.000 24.99722 ? 408 LEU   A CB  1 
ATOM   1529 C CG  . LEU   A 1 212 ? -7.02181  -17.24092 -13.62343 1.000 27.49031 ? 408 LEU   A CG  1 
ATOM   1530 C CD1 . LEU   A 1 212 ? -7.28867  -16.41513 -14.87260 1.000 26.82528 ? 408 LEU   A CD1 1 
ATOM   1531 C CD2 . LEU   A 1 212 ? -5.64019  -17.87941 -13.68633 1.000 25.51023 ? 408 LEU   A CD2 1 
ATOM   1532 N N   . ARG   A 1 213 ? -9.59736  -18.11830 -11.09305 1.000 31.39608 ? 409 ARG   A N   1 
ATOM   1533 C CA  . ARG   A 1 213 ? -10.48661 -19.27352 -11.17014 1.000 33.75648 ? 409 ARG   A CA  1 
ATOM   1534 C C   . ARG   A 1 213 ? -11.94343 -18.83915 -11.28332 1.000 31.63335 ? 409 ARG   A C   1 
ATOM   1535 O O   . ARG   A 1 213 ? -12.69206 -19.34974 -12.12471 1.000 36.81525 ? 409 ARG   A O   1 
ATOM   1536 C CB  . ARG   A 1 213 ? -10.28476 -20.17085 -9.94850  1.000 38.34562 ? 409 ARG   A CB  1 
ATOM   1537 C CG  . ARG   A 1 213 ? -9.50820  -21.44243 -10.23361 1.000 38.60167 ? 409 ARG   A CG  1 
ATOM   1538 C CD  . ARG   A 1 213 ? -9.61522  -22.42833 -9.08076  1.000 42.33768 ? 409 ARG   A CD  1 
ATOM   1539 N NE  . ARG   A 1 213 ? -8.71456  -22.08498 -7.98707  1.000 50.78932 ? 409 ARG   A NE  1 
ATOM   1540 C CZ  . ARG   A 1 213 ? -9.02168  -22.19332 -6.70166  1.000 56.99750 ? 409 ARG   A CZ  1 
ATOM   1541 N NH1 . ARG   A 1 213 ? -10.20225 -22.64319 -6.30870  1.000 55.58056 ? 409 ARG   A NH1 1 
ATOM   1542 N NH2 . ARG   A 1 213 ? -8.12149  -21.84191 -5.78748  1.000 57.07901 ? 409 ARG   A NH2 1 
ATOM   1543 N N   . LEU   A 1 214 ? -12.36380 -17.89159 -10.44050 1.000 32.08238 ? 410 LEU   A N   1 
ATOM   1544 C CA  . LEU   A 1 214 ? -13.74164 -17.41233 -10.49724 1.000 36.25064 ? 410 LEU   A CA  1 
ATOM   1545 C C   . LEU   A 1 214 ? -14.01490 -16.66794 -11.79652 1.000 35.12027 ? 410 LEU   A C   1 
ATOM   1546 O O   . LEU   A 1 214 ? -15.10114 -16.79398 -12.37418 1.000 34.96513 ? 410 LEU   A O   1 
ATOM   1547 C CB  . LEU   A 1 214 ? -14.03998 -16.50934 -9.30117  1.000 34.99856 ? 410 LEU   A CB  1 
ATOM   1548 C CG  . LEU   A 1 214 ? -13.95740 -17.11951 -7.90357  1.000 38.77939 ? 410 LEU   A CG  1 
ATOM   1549 C CD1 . LEU   A 1 214 ? -13.46227 -16.07629 -6.91908  1.000 47.55710 ? 410 LEU   A CD1 1 
ATOM   1550 C CD2 . LEU   A 1 214 ? -15.30967 -17.67097 -7.47647  1.000 42.90268 ? 410 LEU   A CD2 1 
ATOM   1551 N N   . HIS   A 1 215 ? -13.04452 -15.88130 -12.26722 1.000 28.63642 ? 411 HIS   A N   1 
ATOM   1552 C CA  . HIS   A 1 215 ? -13.23553 -15.14462 -13.51097 1.000 29.22922 ? 411 HIS   A CA  1 
ATOM   1553 C C   . HIS   A 1 215 ? -13.39127 -16.09338 -14.69185 1.000 28.06312 ? 411 HIS   A C   1 
ATOM   1554 O O   . HIS   A 1 215 ? -14.23889 -15.87481 -15.56488 1.000 28.68602 ? 411 HIS   A O   1 
ATOM   1555 C CB  . HIS   A 1 215 ? -12.06811 -14.18462 -13.73835 1.000 28.37622 ? 411 HIS   A CB  1 
ATOM   1556 C CG  . HIS   A 1 215 ? -12.22810 -13.31887 -14.94854 1.000 31.82438 ? 411 HIS   A CG  1 
ATOM   1557 N ND1 . HIS   A 1 215 ? -12.92978 -12.13275 -14.92805 1.000 30.68777 ? 411 HIS   A ND1 1 
ATOM   1558 C CD2 . HIS   A 1 215 ? -11.77930 -13.46825 -16.21693 1.000 30.23965 ? 411 HIS   A CD2 1 
ATOM   1559 C CE1 . HIS   A 1 215 ? -12.90526 -11.58809 -16.13152 1.000 33.98359 ? 411 HIS   A CE1 1 
ATOM   1560 N NE2 . HIS   A 1 215 ? -12.21340 -12.37876 -16.93223 1.000 32.71167 ? 411 HIS   A NE2 1 
ATOM   1561 N N   . LEU   A 1 216 ? -12.58325 -17.15609 -14.73555 1.000 27.83345 ? 412 LEU   A N   1 
ATOM   1562 C CA  . LEU   A 1 216 ? -12.72705 -18.14391 -15.79919 1.000 30.65782 ? 412 LEU   A CA  1 
ATOM   1563 C C   . LEU   A 1 216 ? -14.07358 -18.85208 -15.71950 1.000 32.10691 ? 412 LEU   A C   1 
ATOM   1564 O O   . LEU   A 1 216 ? -14.65069 -19.20660 -16.75396 1.000 34.96078 ? 412 LEU   A O   1 
ATOM   1565 C CB  . LEU   A 1 216 ? -11.58105 -19.15790 -15.73589 1.000 30.12367 ? 412 LEU   A CB  1 
ATOM   1566 C CG  . LEU   A 1 216 ? -10.17012 -18.64554 -16.05213 1.000 27.49249 ? 412 LEU   A CG  1 
ATOM   1567 C CD1 . LEU   A 1 216 ? -9.13013  -19.74440 -15.86104 1.000 30.47487 ? 412 LEU   A CD1 1 
ATOM   1568 C CD2 . LEU   A 1 216 ? -10.09005 -18.06489 -17.45957 1.000 25.03398 ? 412 LEU   A CD2 1 
ATOM   1569 N N   . GLN   A 1 217 ? -14.59350 -19.05465 -14.50557 1.000 33.73323 ? 413 GLN   A N   1 
ATOM   1570 C CA  . GLN   A 1 217 ? -15.89626 -19.69168 -14.34742 1.000 37.60891 ? 413 GLN   A CA  1 
ATOM   1571 C C   . GLN   A 1 217 ? -17.02064 -18.81101 -14.88239 1.000 38.46917 ? 413 GLN   A C   1 
ATOM   1572 O O   . GLN   A 1 217 ? -17.99039 -19.32647 -15.45133 1.000 41.59864 ? 413 GLN   A O   1 
ATOM   1573 C CB  . GLN   A 1 217 ? -16.11714 -20.04474 -12.87239 1.000 40.14186 ? 413 GLN   A CB  1 
ATOM   1574 C CG  . GLN   A 1 217 ? -17.56501 -20.03847 -12.39433 1.000 53.12793 ? 413 GLN   A CG  1 
ATOM   1575 C CD  . GLN   A 1 217 ? -17.99591 -18.69440 -11.83191 1.000 58.53872 ? 413 GLN   A CD  1 
ATOM   1576 O OE1 . GLN   A 1 217 ? -17.48628 -18.24345 -10.80412 1.000 55.33598 ? 413 GLN   A OE1 1 
ATOM   1577 N NE2 . GLN   A 1 217 ? -18.94647 -18.05275 -12.49976 1.000 57.28602 ? 413 GLN   A NE2 1 
ATOM   1578 N N   . SER   A 1 218 ? -16.90337 -17.48945 -14.72200 1.000 36.95725 ? 414 SER   A N   1 
ATOM   1579 C CA  . SER   A 1 218 ? -17.88911 -16.53303 -15.21838 1.000 36.17760 ? 414 SER   A CA  1 
ATOM   1580 C C   . SER   A 1 218 ? -17.69808 -16.20025 -16.69329 1.000 38.03820 ? 414 SER   A C   1 
ATOM   1581 O O   . SER   A 1 218 ? -18.68348 -16.05150 -17.42419 1.000 40.19130 ? 414 SER   A O   1 
ATOM   1582 C CB  . SER   A 1 218 ? -17.82996 -15.23567 -14.40349 1.000 38.88934 ? 414 SER   A CB  1 
ATOM   1583 O OG  . SER   A 1 218 ? -17.92944 -15.48164 -13.01089 1.000 38.64268 ? 414 SER   A OG  1 
ATOM   1584 N N   . ASN   A 1 219 ? -16.44750 -16.06742 -17.14401 1.000 36.30155 ? 415 ASN   A N   1 
ATOM   1585 C CA  . ASN   A 1 219 ? -16.18650 -15.62623 -18.51028 1.000 34.67330 ? 415 ASN   A CA  1 
ATOM   1586 C C   . ASN   A 1 219 ? -16.22914 -16.77340 -19.51126 1.000 31.25900 ? 415 ASN   A C   1 
ATOM   1587 O O   . ASN   A 1 219 ? -16.51046 -16.54425 -20.69245 1.000 31.26899 ? 415 ASN   A O   1 
ATOM   1588 C CB  . ASN   A 1 219 ? -14.83016 -14.92091 -18.58570 1.000 35.03414 ? 415 ASN   A CB  1 
ATOM   1589 C CG  . ASN   A 1 219 ? -14.73735 -13.94991 -19.75018 1.000 39.48651 ? 415 ASN   A CG  1 
ATOM   1590 O OD1 . ASN   A 1 219 ? -15.74930 -13.45069 -20.24283 1.000 40.09561 ? 415 ASN   A OD1 1 
ATOM   1591 N ND2 . ASN   A 1 219 ? -13.51582 -13.67786 -20.19545 1.000 30.38886 ? 415 ASN   A ND2 1 
ATOM   1592 N N   . HIS   A 1 220 ? -15.95332 -18.00016 -19.07366 1.000 31.19080 ? 416 HIS   A N   1 
ATOM   1593 C CA  . HIS   A 1 220 ? -15.93497 -19.16989 -19.95215 1.000 31.38714 ? 416 HIS   A CA  1 
ATOM   1594 C C   . HIS   A 1 220 ? -16.72816 -20.30440 -19.31627 1.000 35.17489 ? 416 HIS   A C   1 
ATOM   1595 O O   . HIS   A 1 220 ? -16.16115 -21.32931 -18.91875 1.000 32.57837 ? 416 HIS   A O   1 
ATOM   1596 C CB  . HIS   A 1 220 ? -14.50058 -19.61107 -20.24704 1.000 28.17954 ? 416 HIS   A CB  1 
ATOM   1597 C CG  . HIS   A 1 220 ? -13.62799 -18.51728 -20.77755 1.000 31.40158 ? 416 HIS   A CG  1 
ATOM   1598 N ND1 . HIS   A 1 220 ? -13.39495 -18.33808 -22.12404 1.000 30.32910 ? 416 HIS   A ND1 1 
ATOM   1599 C CD2 . HIS   A 1 220 ? -12.93025 -17.54621 -20.14257 1.000 30.02255 ? 416 HIS   A CD2 1 
ATOM   1600 C CE1 . HIS   A 1 220 ? -12.59301 -17.30257 -22.29616 1.000 33.75695 ? 416 HIS   A CE1 1 
ATOM   1601 N NE2 . HIS   A 1 220 ? -12.29571 -16.80449 -21.10959 1.000 35.07860 ? 416 HIS   A NE2 1 
ATOM   1602 N N   . PRO   A 1 221 ? -18.05440 -20.16122 -19.21816 1.000 34.14439 ? 417 PRO   A N   1 
ATOM   1603 C CA  . PRO   A 1 221 ? -18.86733 -21.25169 -18.65774 1.000 33.99496 ? 417 PRO   A CA  1 
ATOM   1604 C C   . PRO   A 1 221 ? -18.96659 -22.46366 -19.56911 1.000 35.88958 ? 417 PRO   A C   1 
ATOM   1605 O O   . PRO   A 1 221 ? -19.40872 -23.52536 -19.11116 1.000 38.59308 ? 417 PRO   A O   1 
ATOM   1606 C CB  . PRO   A 1 221 ? -20.23738 -20.59527 -18.45504 1.000 34.06358 ? 417 PRO   A CB  1 
ATOM   1607 C CG  . PRO   A 1 221 ? -20.29648 -19.54680 -19.51246 1.000 35.06626 ? 417 PRO   A CG  1 
ATOM   1608 C CD  . PRO   A 1 221 ? -18.88588 -19.03274 -19.67617 1.000 36.78569 ? 417 PRO   A CD  1 
ATOM   1609 N N   . ASP   A 1 222 ? -18.56894 -22.34070 -20.83547 1.000 36.04474 ? 418 ASP   A N   1 
ATOM   1610 C CA  . ASP   A 1 222 ? -18.61007 -23.45074 -21.77712 1.000 38.14622 ? 418 ASP   A CA  1 
ATOM   1611 C C   . ASP   A 1 222 ? -17.43904 -24.41194 -21.61916 1.000 35.72091 ? 418 ASP   A C   1 
ATOM   1612 O O   . ASP   A 1 222 ? -17.48938 -25.51727 -22.16916 1.000 40.10814 ? 418 ASP   A O   1 
ATOM   1613 C CB  . ASP   A 1 222 ? -18.63760 -22.91353 -23.20942 1.000 40.40982 ? 418 ASP   A CB  1 
ATOM   1614 C CG  . ASP   A 1 222 ? -17.47429 -21.98307 -23.50349 1.000 45.72978 ? 418 ASP   A CG  1 
ATOM   1615 O OD1 . ASP   A 1 222 ? -17.06438 -21.23316 -22.59168 1.000 37.04204 ? 418 ASP   A OD1 1 
ATOM   1616 O OD2 . ASP   A 1 222 ? -16.96869 -22.00261 -24.64509 1.000 49.94378 ? 418 ASP   A OD2 1 
ATOM   1617 N N   . ASP   A 1 223 ? -16.39102 -24.02241 -20.89284 1.000 33.36558 ? 419 ASP   A N   1 
ATOM   1618 C CA  . ASP   A 1 223 ? -15.20490 -24.85506 -20.68561 1.000 39.38060 ? 419 ASP   A CA  1 
ATOM   1619 C C   . ASP   A 1 223 ? -14.91879 -24.88378 -19.18740 1.000 37.55984 ? 419 ASP   A C   1 
ATOM   1620 O O   . ASP   A 1 223 ? -14.17448 -24.04667 -18.67026 1.000 31.67931 ? 419 ASP   A O   1 
ATOM   1621 C CB  . ASP   A 1 223 ? -14.01442 -24.32593 -21.48348 1.000 39.92309 ? 419 ASP   A CB  1 
ATOM   1622 C CG  . ASP   A 1 223 ? -12.81076 -25.24989 -21.42219 1.000 39.79103 ? 419 ASP   A CG  1 
ATOM   1623 O OD1 . ASP   A 1 223 ? -12.93283 -26.36245 -20.86662 1.000 39.48620 ? 419 ASP   A OD1 1 
ATOM   1624 O OD2 . ASP   A 1 223 ? -11.74049 -24.86419 -21.93687 1.000 41.28045 ? 419 ASP   A OD2 1 
ATOM   1625 N N   . ILE   A 1 224 ? -15.51136 -25.85870 -18.48959 1.000 39.44793 ? 420 ILE   A N   1 
ATOM   1626 C CA  . ILE   A 1 224 ? -15.33937 -25.96231 -17.04169 1.000 42.73765 ? 420 ILE   A CA  1 
ATOM   1627 C C   . ILE   A 1 224 ? -13.99851 -26.55742 -16.64985 1.000 40.00133 ? 420 ILE   A C   1 
ATOM   1628 O O   . ILE   A 1 224 ? -13.70845 -26.66445 -15.45124 1.000 43.59835 ? 420 ILE   A O   1 
ATOM   1629 C CB  . ILE   A 1 224 ? -16.48493 -26.78652 -16.42084 1.000 47.11743 ? 420 ILE   A CB  1 
ATOM   1630 C CG1 . ILE   A 1 224 ? -16.36077 -28.25714 -16.81602 1.000 46.04198 ? 420 ILE   A CG1 1 
ATOM   1631 C CG2 . ILE   A 1 224 ? -17.82767 -26.23457 -16.86611 1.000 50.21730 ? 420 ILE   A CG2 1 
ATOM   1632 C CD1 . ILE   A 1 224 ? -17.50600 -29.12026 -16.33279 1.000 49.98834 ? 420 ILE   A CD1 1 
ATOM   1633 N N   . PHE   A 1 225 ? -13.16939 -26.94755 -17.61867 1.000 35.70698 ? 421 PHE   A N   1 
ATOM   1634 C CA  . PHE   A 1 225 ? -11.81062 -27.40669 -17.35877 1.000 34.97841 ? 421 PHE   A CA  1 
ATOM   1635 C C   . PHE   A 1 225 ? -10.77171 -26.44146 -17.92298 1.000 37.03880 ? 421 PHE   A C   1 
ATOM   1636 O O   . PHE   A 1 225 ? -9.64103  -26.83691 -18.21751 1.000 35.75582 ? 421 PHE   A O   1 
ATOM   1637 C CB  . PHE   A 1 225 ? -11.58880 -28.80795 -17.92596 1.000 38.63184 ? 421 PHE   A CB  1 
ATOM   1638 C CG  . PHE   A 1 225 ? -12.58825 -29.82613 -17.45147 1.000 37.03032 ? 421 PHE   A CG  1 
ATOM   1639 C CD1 . PHE   A 1 225 ? -13.71081 -30.12336 -18.20780 1.000 43.71215 ? 421 PHE   A CD1 1 
ATOM   1640 C CD2 . PHE   A 1 225 ? -12.41078 -30.47653 -16.24154 1.000 41.84898 ? 421 PHE   A CD2 1 
ATOM   1641 C CE1 . PHE   A 1 225 ? -14.62891 -31.06439 -17.77318 1.000 43.41055 ? 421 PHE   A CE1 1 
ATOM   1642 C CE2 . PHE   A 1 225 ? -13.32660 -31.41277 -15.79917 1.000 41.43045 ? 421 PHE   A CE2 1 
ATOM   1643 C CZ  . PHE   A 1 225 ? -14.43757 -31.70616 -16.56468 1.000 44.09874 ? 421 PHE   A CZ  1 
ATOM   1644 N N   . LEU   A 1 226 ? -11.14264 -25.16878 -18.07596 1.000 37.21695 ? 422 LEU   A N   1 
ATOM   1645 C CA  . LEU   A 1 226 ? -10.21679 -24.19490 -18.64584 1.000 34.98227 ? 422 LEU   A CA  1 
ATOM   1646 C C   . LEU   A 1 226 ? -9.07677  -23.87796 -17.68462 1.000 31.43238 ? 422 LEU   A C   1 
ATOM   1647 O O   . LEU   A 1 226 ? -7.93626  -23.66837 -18.11557 1.000 29.37090 ? 422 LEU   A O   1 
ATOM   1648 C CB  . LEU   A 1 226 ? -10.96616 -22.91820 -19.02854 1.000 26.78404 ? 422 LEU   A CB  1 
ATOM   1649 C CG  . LEU   A 1 226 ? -10.11175 -21.80813 -19.64671 1.000 32.18220 ? 422 LEU   A CG  1 
ATOM   1650 C CD1 . LEU   A 1 226 ? -9.35636  -22.32809 -20.86019 1.000 28.42827 ? 422 LEU   A CD1 1 
ATOM   1651 C CD2 . LEU   A 1 226 ? -10.96953 -20.60989 -20.01786 1.000 30.04409 ? 422 LEU   A CD2 1 
ATOM   1652 N N   . PHE   A 1 227 ? -9.36086  -23.83977 -16.38164 1.000 29.35626 ? 423 PHE   A N   1 
ATOM   1653 C CA  . PHE   A 1 227 ? -8.32155  -23.49381 -15.41252 1.000 28.66883 ? 423 PHE   A CA  1 
ATOM   1654 C C   . PHE   A 1 227 ? -7.17640  -24.50087 -15.38204 1.000 30.45788 ? 423 PHE   A C   1 
ATOM   1655 O O   . PHE   A 1 227 ? -6.01046  -24.06862 -15.39795 1.000 28.32419 ? 423 PHE   A O   1 
ATOM   1656 C CB  . PHE   A 1 227 ? -8.94347  -23.30806 -14.02391 1.000 26.30647 ? 423 PHE   A CB  1 
ATOM   1657 C CG  . PHE   A 1 227 ? -7.93233  -23.08793 -12.93349 1.000 31.20126 ? 423 PHE   A CG  1 
ATOM   1658 C CD1 . PHE   A 1 227 ? -7.16801  -21.93191 -12.89924 1.000 27.23033 ? 423 PHE   A CD1 1 
ATOM   1659 C CD2 . PHE   A 1 227 ? -7.73896  -24.04191 -11.94838 1.000 36.46073 ? 423 PHE   A CD2 1 
ATOM   1660 C CE1 . PHE   A 1 227 ? -6.23543  -21.72919 -11.89751 1.000 28.72180 ? 423 PHE   A CE1 1 
ATOM   1661 C CE2 . PHE   A 1 227 ? -6.80718  -23.84607 -10.94502 1.000 35.90236 ? 423 PHE   A CE2 1 
ATOM   1662 C CZ  . PHE   A 1 227 ? -6.05438  -22.68962 -10.92003 1.000 37.17787 ? 423 PHE   A CZ  1 
ATOM   1663 N N   . PRO   A 1 228 ? -7.40572  -25.82032 -15.32775 1.000 29.59960 ? 424 PRO   A N   1 
ATOM   1664 C CA  . PRO   A 1 228 ? -6.25810  -26.74152 -15.41447 1.000 32.40747 ? 424 PRO   A CA  1 
ATOM   1665 C C   . PRO   A 1 228 ? -5.51665  -26.64923 -16.73754 1.000 28.30849 ? 424 PRO   A C   1 
ATOM   1666 O O   . PRO   A 1 228 ? -4.30604  -26.90546 -16.77640 1.000 30.12024 ? 424 PRO   A O   1 
ATOM   1667 C CB  . PRO   A 1 228 ? -6.88950  -28.12764 -15.20924 1.000 29.86525 ? 424 PRO   A CB  1 
ATOM   1668 C CG  . PRO   A 1 228 ? -8.34233  -27.94729 -15.43843 1.000 33.13711 ? 424 PRO   A CG  1 
ATOM   1669 C CD  . PRO   A 1 228 ? -8.66240  -26.54104 -15.05189 1.000 33.67091 ? 424 PRO   A CD  1 
ATOM   1670 N N   . LYS   A 1 229 ? -6.20637  -26.29199 -17.82464 1.000 31.07826 ? 425 LYS   A N   1 
ATOM   1671 C CA  . LYS   A 1 229 ? -5.52027  -26.02818 -19.08626 1.000 30.84714 ? 425 LYS   A CA  1 
ATOM   1672 C C   . LYS   A 1 229 ? -4.52344  -24.88659 -18.93297 1.000 29.37232 ? 425 LYS   A C   1 
ATOM   1673 O O   . LYS   A 1 229 ? -3.38059  -24.97580 -19.39580 1.000 26.64983 ? 425 LYS   A O   1 
ATOM   1674 C CB  . LYS   A 1 229 ? -6.53507  -25.69753 -20.18156 1.000 31.80706 ? 425 LYS   A CB  1 
ATOM   1675 C CG  . LYS   A 1 229 ? -7.43801  -26.84227 -20.59976 1.000 37.07742 ? 425 LYS   A CG  1 
ATOM   1676 C CD  . LYS   A 1 229 ? -8.44157  -26.36812 -21.64351 1.000 39.32183 ? 425 LYS   A CD  1 
ATOM   1677 C CE  . LYS   A 1 229 ? -9.16724  -27.53164 -22.29415 1.000 47.62558 ? 425 LYS   A CE  1 
ATOM   1678 N NZ  . LYS   A 1 229 ? -10.63437 -27.29603 -22.38345 1.000 45.89195 ? 425 LYS   A NZ  1 
ATOM   1679 N N   . LEU   A 1 230 ? -4.94686  -23.79717 -18.28479 1.000 27.79037 ? 426 LEU   A N   1 
ATOM   1680 C CA  . LEU   A 1 230 ? -4.06941  -22.64603 -18.10459 1.000 30.99705 ? 426 LEU   A CA  1 
ATOM   1681 C C   . LEU   A 1 230 ? -2.91442  -22.96049 -17.16458 1.000 28.82927 ? 426 LEU   A C   1 
ATOM   1682 O O   . LEU   A 1 230 ? -1.81931  -22.40904 -17.32597 1.000 29.13747 ? 426 LEU   A O   1 
ATOM   1683 C CB  . LEU   A 1 230 ? -4.87073  -21.45428 -17.58171 1.000 28.84654 ? 426 LEU   A CB  1 
ATOM   1684 C CG  . LEU   A 1 230 ? -5.59791  -20.62215 -18.63860 1.000 31.52697 ? 426 LEU   A CG  1 
ATOM   1685 C CD1 . LEU   A 1 230 ? -6.14781  -19.34399 -18.02991 1.000 31.68551 ? 426 LEU   A CD1 1 
ATOM   1686 C CD2 . LEU   A 1 230 ? -4.66653  -20.30759 -19.79829 1.000 36.38070 ? 426 LEU   A CD2 1 
ATOM   1687 N N   . LEU   A 1 231 ? -3.14014  -23.83188 -16.17790 1.000 28.17207 ? 427 LEU   A N   1 
ATOM   1688 C CA  . LEU   A 1 231 ? -2.05181  -24.26384 -15.30791 1.000 27.66278 ? 427 LEU   A CA  1 
ATOM   1689 C C   . LEU   A 1 231 ? -0.95781  -24.95841 -16.10791 1.000 30.39182 ? 427 LEU   A C   1 
ATOM   1690 O O   . LEU   A 1 231 ? 0.23495   -24.75079 -15.85589 1.000 30.59162 ? 427 LEU   A O   1 
ATOM   1691 C CB  . LEU   A 1 231 ? -2.58964  -25.19073 -14.21754 1.000 29.60300 ? 427 LEU   A CB  1 
ATOM   1692 C CG  . LEU   A 1 231 ? -3.29848  -24.52844 -13.03398 1.000 31.96026 ? 427 LEU   A CG  1 
ATOM   1693 C CD1 . LEU   A 1 231 ? -3.79498  -25.57983 -12.05314 1.000 31.20215 ? 427 LEU   A CD1 1 
ATOM   1694 C CD2 . LEU   A 1 231 ? -2.38235  -23.53090 -12.33975 1.000 27.06557 ? 427 LEU   A CD2 1 
ATOM   1695 N N   . GLN   A 1 232 ? -1.34598  -25.78499 -17.08249 1.000 29.24019 ? 428 GLN   A N   1 
ATOM   1696 C CA  . GLN   A 1 232 ? -0.35673  -26.44754 -17.92477 1.000 32.98914 ? 428 GLN   A CA  1 
ATOM   1697 C C   . GLN   A 1 232 ? 0.36204   -25.45549 -18.83054 1.000 30.95051 ? 428 GLN   A C   1 
ATOM   1698 O O   . GLN   A 1 232 ? 1.54351   -25.64630 -19.13991 1.000 32.84058 ? 428 GLN   A O   1 
ATOM   1699 C CB  . GLN   A 1 232 ? -1.02412  -27.54425 -18.75623 1.000 35.29206 ? 428 GLN   A CB  1 
ATOM   1700 C CG  . GLN   A 1 232 ? -0.05652  -28.36259 -19.59708 1.000 34.65826 ? 428 GLN   A CG  1 
ATOM   1701 C CD  . GLN   A 1 232 ? -0.74949  -29.44685 -20.39729 1.000 40.95511 ? 428 GLN   A CD  1 
ATOM   1702 O OE1 . GLN   A 1 232 ? -1.67355  -29.17449 -21.16344 1.000 41.33694 ? 428 GLN   A OE1 1 
ATOM   1703 N NE2 . GLN   A 1 232 ? -0.30396  -30.68582 -20.22456 1.000 42.88504 ? 428 GLN   A NE2 1 
ATOM   1704 N N   . LYS   A 1 233 ? -0.32701  -24.39480 -19.26341 1.000 29.90675 ? 429 LYS   A N   1 
ATOM   1705 C CA  . LYS   A 1 233 ? 0.32601   -23.37677 -20.08006 1.000 25.16670 ? 429 LYS   A CA  1 
ATOM   1706 C C   . LYS   A 1 233 ? 1.39709   -22.63156 -19.29478 1.000 28.46523 ? 429 LYS   A C   1 
ATOM   1707 O O   . LYS   A 1 233 ? 2.39443   -22.18996 -19.87688 1.000 29.97308 ? 429 LYS   A O   1 
ATOM   1708 C CB  . LYS   A 1 233 ? -0.70738  -22.39299 -20.63082 1.000 25.11025 ? 429 LYS   A CB  1 
ATOM   1709 C CG  . LYS   A 1 233 ? -1.77152  -23.03036 -21.50809 1.000 29.04438 ? 429 LYS   A CG  1 
ATOM   1710 C CD  . LYS   A 1 233 ? -1.15731  -23.72624 -22.71268 1.000 34.79096 ? 429 LYS   A CD  1 
ATOM   1711 C CE  . LYS   A 1 233 ? -2.23248  -24.23540 -23.66005 1.000 36.96143 ? 429 LYS   A CE  1 
ATOM   1712 N NZ  . LYS   A 1 233 ? -1.69259  -25.22585 -24.63163 1.000 33.36878 ? 429 LYS   A NZ  1 
ATOM   1713 N N   . MET   A 1 234 ? 1.20974   -22.47819 -17.98130 1.000 27.27047 ? 430 MET   A N   1 
ATOM   1714 C CA  . MET   A 1 234 ? 2.24504   -21.86590 -17.15433 1.000 29.70512 ? 430 MET   A CA  1 
ATOM   1715 C C   . MET   A 1 234 ? 3.50392   -22.72303 -17.12834 1.000 30.04408 ? 430 MET   A C   1 
ATOM   1716 O O   . MET   A 1 234 ? 4.62335   -22.19910 -17.17373 1.000 31.34011 ? 430 MET   A O   1 
ATOM   1717 C CB  . MET   A 1 234 ? 1.72000   -21.64050 -15.73712 1.000 33.24262 ? 430 MET   A CB  1 
ATOM   1718 C CG  . MET   A 1 234 ? 0.61352   -20.60551 -15.64522 1.000 33.76765 ? 430 MET   A CG  1 
ATOM   1719 S SD  . MET   A 1 234 ? 0.00481   -20.38796 -13.96283 1.000 43.02620 ? 430 MET   A SD  1 
ATOM   1720 C CE  . MET   A 1 234 ? 1.16042   -19.16562 -13.34408 1.000 35.90611 ? 430 MET   A CE  1 
ATOM   1721 N N   . ALA   A 1 235 ? 3.34080   -24.04585 -17.05173 1.000 31.96903 ? 431 ALA   A N   1 
ATOM   1722 C CA  . ALA   A 1 235 ? 4.49478   -24.93534 -17.11566 1.000 28.78206 ? 431 ALA   A CA  1 
ATOM   1723 C C   . ALA   A 1 235 ? 5.09517   -24.96942 -18.51431 1.000 31.75602 ? 431 ALA   A C   1 
ATOM   1724 O O   . ALA   A 1 235 ? 6.31769   -25.08148 -18.66029 1.000 38.21514 ? 431 ALA   A O   1 
ATOM   1725 C CB  . ALA   A 1 235 ? 4.10101   -26.34355 -16.67121 1.000 33.96084 ? 431 ALA   A CB  1 
ATOM   1726 N N   . ASP   A 1 236 ? 4.25643   -24.87525 -19.54949 1.000 35.21414 ? 432 ASP   A N   1 
ATOM   1727 C CA  . ASP   A 1 236 ? 4.76803   -24.81547 -20.91406 1.000 30.44696 ? 432 ASP   A CA  1 
ATOM   1728 C C   . ASP   A 1 236 ? 5.58972   -23.55478 -21.14591 1.000 34.12654 ? 432 ASP   A C   1 
ATOM   1729 O O   . ASP   A 1 236 ? 6.57579   -23.58477 -21.89149 1.000 30.73182 ? 432 ASP   A O   1 
ATOM   1730 C CB  . ASP   A 1 236 ? 3.61152   -24.87899 -21.91233 1.000 34.06751 ? 432 ASP   A CB  1 
ATOM   1731 C CG  . ASP   A 1 236 ? 2.93756   -26.23685 -21.94251 1.000 36.95626 ? 432 ASP   A CG  1 
ATOM   1732 O OD1 . ASP   A 1 236 ? 3.46025   -27.18172 -21.31488 1.000 35.87543 ? 432 ASP   A OD1 1 
ATOM   1733 O OD2 . ASP   A 1 236 ? 1.88016   -26.35726 -22.59505 1.000 37.68903 ? 432 ASP   A OD2 1 
ATOM   1734 N N   . LEU   A 1 237 ? 5.20268   -22.44158 -20.51654 1.000 29.52359 ? 433 LEU   A N   1 
ATOM   1735 C CA  . LEU   A 1 237 ? 5.92673   -21.18938 -20.71089 1.000 33.71114 ? 433 LEU   A CA  1 
ATOM   1736 C C   . LEU   A 1 237 ? 7.29755   -21.23138 -20.04884 1.000 32.99502 ? 433 LEU   A C   1 
ATOM   1737 O O   . LEU   A 1 237 ? 8.27675   -20.72416 -20.60834 1.000 29.76409 ? 433 LEU   A O   1 
ATOM   1738 C CB  . LEU   A 1 237 ? 5.10804   -20.01764 -20.16893 1.000 27.59550 ? 433 LEU   A CB  1 
ATOM   1739 C CG  . LEU   A 1 237 ? 4.01230   -19.48456 -21.09228 1.000 29.27118 ? 433 LEU   A CG  1 
ATOM   1740 C CD1 . LEU   A 1 237 ? 2.94448   -18.74188 -20.30060 1.000 30.16684 ? 433 LEU   A CD1 1 
ATOM   1741 C CD2 . LEU   A 1 237 ? 4.60472   -18.59240 -22.17432 1.000 32.42993 ? 433 LEU   A CD2 1 
ATOM   1742 N N   . ARG   A 1 238 ? 7.38724   -21.82366 -18.85468 1.000 31.27920 ? 434 ARG   A N   1 
ATOM   1743 C CA  . ARG   A 1 238 ? 8.67338   -21.90354 -18.16946 1.000 36.36890 ? 434 ARG   A CA  1 
ATOM   1744 C C   . ARG   A 1 238 ? 9.66926   -22.73562 -18.96717 1.000 35.10364 ? 434 ARG   A C   1 
ATOM   1745 O O   . ARG   A 1 238 ? 10.86182  -22.41188 -19.01688 1.000 33.78731 ? 434 ARG   A O   1 
ATOM   1746 C CB  . ARG   A 1 238 ? 8.48887   -22.48006 -16.76534 1.000 36.16707 ? 434 ARG   A CB  1 
ATOM   1747 C CG  . ARG   A 1 238 ? 9.70389   -22.31293 -15.86596 1.000 40.05521 ? 434 ARG   A CG  1 
ATOM   1748 C CD  . ARG   A 1 238 ? 9.44394   -22.84915 -14.46687 1.000 47.51615 ? 434 ARG   A CD  1 
ATOM   1749 N NE  . ARG   A 1 238 ? 8.30089   -22.20525 -13.83005 1.000 48.07812 ? 434 ARG   A NE  1 
ATOM   1750 C CZ  . ARG   A 1 238 ? 8.16935   -22.03996 -12.52063 1.000 48.61311 ? 434 ARG   A CZ  1 
ATOM   1751 N NH1 . ARG   A 1 238 ? 9.09553   -22.46041 -11.67440 1.000 51.45660 ? 434 ARG   A NH1 1 
ATOM   1752 N NH2 . ARG   A 1 238 ? 7.08118   -21.43818 -12.04815 1.000 47.83310 ? 434 ARG   A NH2 1 
ATOM   1753 N N   . GLN   A 1 239 ? 9.19643   -23.80869 -19.60527 1.000 35.45813 ? 435 GLN   A N   1 
ATOM   1754 C CA  . GLN   A 1 239 ? 10.07282  -24.60736 -20.45517 1.000 37.41791 ? 435 GLN   A CA  1 
ATOM   1755 C C   . GLN   A 1 239 ? 10.41039  -23.86780 -21.74357 1.000 39.68639 ? 435 GLN   A C   1 
ATOM   1756 O O   . GLN   A 1 239 ? 11.53769  -23.96139 -22.24327 1.000 36.46841 ? 435 GLN   A O   1 
ATOM   1757 C CB  . GLN   A 1 239 ? 9.42047   -25.95574 -20.76219 1.000 35.29653 ? 435 GLN   A CB  1 
ATOM   1758 C CG  . GLN   A 1 239 ? 10.31092  -26.91738 -21.53518 1.000 44.60599 ? 435 GLN   A CG  1 
ATOM   1759 C CD  . GLN   A 1 239 ? 11.55879  -27.30420 -20.76363 1.000 48.93735 ? 435 GLN   A CD  1 
ATOM   1760 O OE1 . GLN   A 1 239 ? 11.52549  -27.45560 -19.54229 1.000 43.48026 ? 435 GLN   A OE1 1 
ATOM   1761 N NE2 . GLN   A 1 239 ? 12.66881  -27.46517 -21.47502 1.000 49.70286 ? 435 GLN   A NE2 1 
ATOM   1762 N N   . LEU   A 1 240 ? 9.44453   -23.12889 -22.29612 1.000 31.93427 ? 436 LEU   A N   1 
ATOM   1763 C CA  . LEU   A 1 240 ? 9.70648   -22.34164 -23.49590 1.000 33.00370 ? 436 LEU   A CA  1 
ATOM   1764 C C   . LEU   A 1 240 ? 10.72535  -21.24123 -23.22956 1.000 34.44015 ? 436 LEU   A C   1 
ATOM   1765 O O   . LEU   A 1 240 ? 11.51120  -20.89395 -24.11879 1.000 34.59173 ? 436 LEU   A O   1 
ATOM   1766 C CB  . LEU   A 1 240 ? 8.39941   -21.74723 -24.02452 1.000 30.69077 ? 436 LEU   A CB  1 
ATOM   1767 C CG  . LEU   A 1 240 ? 8.44549   -21.00281 -25.36006 1.000 37.14855 ? 436 LEU   A CG  1 
ATOM   1768 C CD1 . LEU   A 1 240 ? 8.61728   -21.97661 -26.51343 1.000 33.44245 ? 436 LEU   A CD1 1 
ATOM   1769 C CD2 . LEU   A 1 240 ? 7.18896   -20.16389 -25.54714 1.000 37.71858 ? 436 LEU   A CD2 1 
ATOM   1770 N N   . VAL   A 1 241 ? 10.73730  -20.69222 -22.01421 1.000 29.40478 ? 437 VAL   A N   1 
ATOM   1771 C CA  . VAL   A 1 241 ? 11.68657  -19.63524 -21.68081 1.000 30.20033 ? 437 VAL   A CA  1 
ATOM   1772 C C   . VAL   A 1 241 ? 13.08156  -20.20856 -21.45599 1.000 38.18009 ? 437 VAL   A C   1 
ATOM   1773 O O   . VAL   A 1 241 ? 14.07942  -19.63327 -21.90628 1.000 33.81000 ? 437 VAL   A O   1 
ATOM   1774 C CB  . VAL   A 1 241 ? 11.18844  -18.84753 -20.45465 1.000 28.07667 ? 437 VAL   A CB  1 
ATOM   1775 C CG1 . VAL   A 1 241 ? 12.31943  -18.03710 -19.83629 1.000 28.08025 ? 437 VAL   A CG1 1 
ATOM   1776 C CG2 . VAL   A 1 241 ? 10.03059  -17.94111 -20.84261 1.000 29.03187 ? 437 VAL   A CG2 1 
ATOM   1777 N N   . THR   A 1 242 ? 13.17691  -21.34727 -20.76238 1.000 35.70969 ? 438 THR   A N   1 
ATOM   1778 C CA  . THR   A 1 242 ? 14.48522  -21.93556 -20.48678 1.000 39.64146 ? 438 THR   A CA  1 
ATOM   1779 C C   . THR   A 1 242 ? 15.19163  -22.33663 -21.77557 1.000 39.90232 ? 438 THR   A C   1 
ATOM   1780 O O   . THR   A 1 242 ? 16.40791  -22.15636 -21.90853 1.000 39.05890 ? 438 THR   A O   1 
ATOM   1781 C CB  . THR   A 1 242 ? 14.34002  -23.14163 -19.55753 1.000 41.73622 ? 438 THR   A CB  1 
ATOM   1782 O OG1 . THR   A 1 242 ? 13.26524  -23.97271 -20.01147 1.000 45.17335 ? 438 THR   A OG1 1 
ATOM   1783 C CG2 . THR   A 1 242 ? 14.05273  -22.68499 -18.13460 1.000 44.60512 ? 438 THR   A CG2 1 
ATOM   1784 N N   . GLU   A 1 243 ? 14.44504  -22.87980 -22.73922 1.000 38.33871 ? 439 GLU   A N   1 
ATOM   1785 C CA  . GLU   A 1 243 ? 15.03388  -23.18192 -24.03814 1.000 41.30483 ? 439 GLU   A CA  1 
ATOM   1786 C C   . GLU   A 1 243 ? 15.33736  -21.91215 -24.82210 1.000 46.49591 ? 439 GLU   A C   1 
ATOM   1787 O O   . GLU   A 1 243 ? 16.27755  -21.89094 -25.62479 1.000 36.80211 ? 439 GLU   A O   1 
ATOM   1788 C CB  . GLU   A 1 243 ? 14.10409  -24.09267 -24.83754 1.000 38.58087 ? 439 GLU   A CB  1 
ATOM   1789 C CG  . GLU   A 1 243 ? 13.74906  -25.38841 -24.12655 1.000 41.85899 ? 439 GLU   A CG  1 
ATOM   1790 C CD  . GLU   A 1 243 ? 12.62965  -26.13782 -24.81621 1.000 46.95616 ? 439 GLU   A CD  1 
ATOM   1791 O OE1 . GLU   A 1 243 ? 12.03035  -25.57353 -25.75512 1.000 50.91857 ? 439 GLU   A OE1 1 
ATOM   1792 O OE2 . GLU   A 1 243 ? 12.34715  -27.28835 -24.41945 1.000 49.94702 ? 439 GLU   A OE2 1 
ATOM   1793 N N   . HIS   A 1 244 ? 14.55745  -20.84935 -24.60656 1.000 40.41814 ? 440 HIS   A N   1 
ATOM   1794 C CA  . HIS   A 1 244 ? 14.83109  -19.58573 -25.28267 1.000 35.34783 ? 440 HIS   A CA  1 
ATOM   1795 C C   . HIS   A 1 244 ? 16.11375  -18.95120 -24.76106 1.000 35.75604 ? 440 HIS   A C   1 
ATOM   1796 O O   . HIS   A 1 244 ? 16.87438  -18.35358 -25.53131 1.000 38.64984 ? 440 HIS   A O   1 
ATOM   1797 C CB  . HIS   A 1 244 ? 13.64839  -18.63123 -25.11256 1.000 35.00972 ? 440 HIS   A CB  1 
ATOM   1798 C CG  . HIS   A 1 244 ? 13.85923  -17.28701 -25.73741 1.000 30.15715 ? 440 HIS   A CG  1 
ATOM   1799 N ND1 . HIS   A 1 244 ? 13.68973  -17.05668 -27.08575 1.000 29.45080 ? 440 HIS   A ND1 1 
ATOM   1800 C CD2 . HIS   A 1 244 ? 14.22412  -16.10065 -25.19689 1.000 32.10362 ? 440 HIS   A CD2 1 
ATOM   1801 C CE1 . HIS   A 1 244 ? 13.94027  -15.78652 -27.34886 1.000 30.97711 ? 440 HIS   A CE1 1 
ATOM   1802 N NE2 . HIS   A 1 244 ? 14.26663  -15.18422 -26.21952 1.000 28.17206 ? 440 HIS   A NE2 1 
ATOM   1803 N N   . ALA   A 1 245 ? 16.37366  -19.07546 -23.45613 1.000 31.53714 ? 441 ALA   A N   1 
ATOM   1804 C CA  . ALA   A 1 245 ? 17.60066  -18.52384 -22.89152 1.000 37.64207 ? 441 ALA   A CA  1 
ATOM   1805 C C   . ALA   A 1 245 ? 18.83437  -19.21198 -23.45877 1.000 43.36047 ? 441 ALA   A C   1 
ATOM   1806 O O   . ALA   A 1 245 ? 19.90841  -18.60322 -23.52969 1.000 37.39346 ? 441 ALA   A O   1 
ATOM   1807 C CB  . ALA   A 1 245 ? 17.57817  -18.64001 -21.36702 1.000 36.51941 ? 441 ALA   A CB  1 
ATOM   1808 N N   . GLN   A 1 246 ? 18.70237  -20.47650 -23.86579 1.000 45.50027 ? 442 GLN   A N   1 
ATOM   1809 C CA  . GLN   A 1 246 ? 19.81762  -21.16712 -24.50168 1.000 50.30585 ? 442 GLN   A CA  1 
ATOM   1810 C C   . GLN   A 1 246 ? 20.12406  -20.58274 -25.87436 1.000 48.19485 ? 442 GLN   A C   1 
ATOM   1811 O O   . GLN   A 1 246 ? 21.28979  -20.54498 -26.28417 1.000 48.44729 ? 442 GLN   A O   1 
ATOM   1812 C CB  . GLN   A 1 246 ? 19.51349  -22.66098 -24.60618 1.000 51.90559 ? 442 GLN   A CB  1 
ATOM   1813 C CG  . GLN   A 1 246 ? 19.40623  -23.35521 -23.25753 1.000 48.77329 ? 442 GLN   A CG  1 
ATOM   1814 C CD  . GLN   A 1 246 ? 19.38242  -24.86564 -23.37604 1.000 59.74173 ? 442 GLN   A CD  1 
ATOM   1815 O OE1 . GLN   A 1 246 ? 18.41349  -25.44631 -23.86572 1.000 58.02395 ? 442 GLN   A OE1 1 
ATOM   1816 N NE2 . GLN   A 1 246 ? 20.45195  -25.51145 -22.92507 1.000 63.98589 ? 442 GLN   A NE2 1 
ATOM   1817 N N   . LEU   A 1 247 ? 19.09800  -20.12262 -26.59541 1.000 46.32866 ? 443 LEU   A N   1 
ATOM   1818 C CA  . LEU   A 1 247 ? 19.33588  -19.42884 -27.85624 1.000 42.84256 ? 443 LEU   A CA  1 
ATOM   1819 C C   . LEU   A 1 247 ? 19.95988  -18.05860 -27.62863 1.000 46.36734 ? 443 LEU   A C   1 
ATOM   1820 O O   . LEU   A 1 247 ? 20.73605  -17.58553 -28.46656 1.000 54.05736 ? 443 LEU   A O   1 
ATOM   1821 C CB  . LEU   A 1 247 ? 18.03023  -19.29161 -28.63832 1.000 44.63824 ? 443 LEU   A CB  1 
ATOM   1822 C CG  . LEU   A 1 247 ? 17.56290  -20.51632 -29.42463 1.000 46.90983 ? 443 LEU   A CG  1 
ATOM   1823 C CD1 . LEU   A 1 247 ? 16.20533  -20.25390 -30.05710 1.000 50.14669 ? 443 LEU   A CD1 1 
ATOM   1824 C CD2 . LEU   A 1 247 ? 18.58580  -20.90053 -30.48281 1.000 47.43421 ? 443 LEU   A CD2 1 
ATOM   1825 N N   . VAL   A 1 248 ? 19.63369  -17.41024 -26.50789 1.000 40.23429 ? 444 VAL   A N   1 
ATOM   1826 C CA  . VAL   A 1 248 ? 20.22918  -16.11489 -26.19109 1.000 39.45572 ? 444 VAL   A CA  1 
ATOM   1827 C C   . VAL   A 1 248 ? 21.73210  -16.25514 -25.98198 1.000 49.13530 ? 444 VAL   A C   1 
ATOM   1828 O O   . VAL   A 1 248 ? 22.51761  -15.40568 -26.42110 1.000 42.59676 ? 444 VAL   A O   1 
ATOM   1829 C CB  . VAL   A 1 248 ? 19.54112  -15.49961 -24.95782 1.000 40.27507 ? 444 VAL   A CB  1 
ATOM   1830 C CG1 . VAL   A 1 248 ? 20.16573  -14.15911 -24.61145 1.000 38.50711 ? 444 VAL   A CG1 1 
ATOM   1831 C CG2 . VAL   A 1 248 ? 18.04779  -15.34533 -25.20256 1.000 41.21101 ? 444 VAL   A CG2 1 
ATOM   1832 N N   . GLN   A 1 249 ? 22.15705  -17.32943 -25.31041 1.000 45.86798 ? 445 GLN   A N   1 
ATOM   1833 C CA  . GLN   A 1 249 ? 23.58185  -17.53469 -25.06901 1.000 47.55739 ? 445 GLN   A CA  1 
ATOM   1834 C C   . GLN   A 1 249 ? 24.32235  -17.90228 -26.34933 1.000 49.26371 ? 445 GLN   A C   1 
ATOM   1835 O O   . GLN   A 1 249 ? 25.48714  -17.52253 -26.52002 1.000 54.66522 ? 445 GLN   A O   1 
ATOM   1836 C CB  . GLN   A 1 249 ? 23.78155  -18.61191 -24.00030 1.000 44.53064 ? 445 GLN   A CB  1 
ATOM   1837 C CG  . GLN   A 1 249 ? 25.23014  -19.03967 -23.78711 1.000 43.50218 ? 445 GLN   A CG  1 
ATOM   1838 C CD  . GLN   A 1 249 ? 26.09218  -17.94350 -23.18474 1.000 48.10795 ? 445 GLN   A CD  1 
ATOM   1839 O OE1 . GLN   A 1 249 ? 25.58901  -17.01473 -22.55131 1.000 42.97543 ? 445 GLN   A OE1 1 
ATOM   1840 N NE2 . GLN   A 1 249 ? 27.40200  -18.04913 -23.38053 1.000 43.52268 ? 445 GLN   A NE2 1 
ATOM   1841 N N   . ILE   A 1 250 ? 23.66807  -18.63047 -27.25703 1.000 44.51076 ? 446 ILE   A N   1 
ATOM   1842 C CA  . ILE   A 1 250 ? 24.29220  -18.97081 -28.53391 1.000 46.33319 ? 446 ILE   A CA  1 
ATOM   1843 C C   . ILE   A 1 250 ? 24.59365  -17.70534 -29.32705 1.000 58.57518 ? 446 ILE   A C   1 
ATOM   1844 O O   . ILE   A 1 250 ? 25.68775  -17.54017 -29.88035 1.000 60.71809 ? 446 ILE   A O   1 
ATOM   1845 C CB  . ILE   A 1 250 ? 23.39344  -19.93519 -29.32930 1.000 46.10607 ? 446 ILE   A CB  1 
ATOM   1846 C CG1 . ILE   A 1 250 ? 23.41191  -21.32855 -28.69775 1.000 47.29563 ? 446 ILE   A CG1 1 
ATOM   1847 C CG2 . ILE   A 1 250 ? 23.82846  -19.99870 -30.78670 1.000 50.99951 ? 446 ILE   A CG2 1 
ATOM   1848 C CD1 . ILE   A 1 250 ? 22.63033  -22.36308 -29.47949 1.000 48.22408 ? 446 ILE   A CD1 1 
ATOM   1849 N N   . ILE   A 1 251 ? 23.62660  -16.78805 -29.38506 1.000 56.20778 ? 447 ILE   A N   1 
ATOM   1850 C CA  . ILE   A 1 251 ? 23.83121  -15.53429 -30.10208 1.000 56.63376 ? 447 ILE   A CA  1 
ATOM   1851 C C   . ILE   A 1 251 ? 24.85613  -14.66574 -29.38173 1.000 58.49942 ? 447 ILE   A C   1 
ATOM   1852 O O   . ILE   A 1 251 ? 25.71128  -14.03649 -30.01590 1.000 62.87243 ? 447 ILE   A O   1 
ATOM   1853 C CB  . ILE   A 1 251 ? 22.48633  -14.80600 -30.28566 1.000 54.28703 ? 447 ILE   A CB  1 
ATOM   1854 C CG1 . ILE   A 1 251 ? 21.66243  -15.48188 -31.38376 1.000 53.07062 ? 447 ILE   A CG1 1 
ATOM   1855 C CG2 . ILE   A 1 251 ? 22.70176  -13.33621 -30.60747 1.000 58.04723 ? 447 ILE   A CG2 1 
ATOM   1856 C CD1 . ILE   A 1 251 ? 20.19430  -15.61595 -31.05237 1.000 57.67435 ? 447 ILE   A CD1 1 
ATOM   1857 N N   . LYS   A 1 252 ? 24.79829  -14.62614 -28.04794 1.000 53.48204 ? 448 LYS   A N   1 
ATOM   1858 C CA  . LYS   A 1 252 ? 25.74772  -13.81496 -27.29194 1.000 57.91316 ? 448 LYS   A CA  1 
ATOM   1859 C C   . LYS   A 1 252 ? 27.18208  -14.28202 -27.50634 1.000 62.55306 ? 448 LYS   A C   1 
ATOM   1860 O O   . LYS   A 1 252 ? 28.10559  -13.46009 -27.54038 1.000 58.34486 ? 448 LYS   A O   1 
ATOM   1861 C CB  . LYS   A 1 252 ? 25.39254  -13.84557 -25.80385 1.000 48.83448 ? 448 LYS   A CB  1 
ATOM   1862 C CG  . LYS   A 1 252 ? 26.43260  -13.21168 -24.89265 1.000 50.84275 ? 448 LYS   A CG  1 
ATOM   1863 C CD  . LYS   A 1 252 ? 26.04666  -13.35224 -23.42929 1.000 56.11131 ? 448 LYS   A CD  1 
ATOM   1864 C CE  . LYS   A 1 252 ? 27.26654  -13.60330 -22.55679 1.000 55.35632 ? 448 LYS   A CE  1 
ATOM   1865 N NZ  . LYS   A 1 252 ? 27.05940  -14.74355 -21.61928 1.000 43.12061 ? 448 LYS   A NZ  1 
ATOM   1866 N N   . LYS   A 1 253 ? 27.38672  -15.58697 -27.67411 1.000 61.12403 ? 449 LYS   A N   1 
ATOM   1867 C CA  . LYS   A 1 253 ? 28.72910  -16.13601 -27.80725 1.000 62.21271 ? 449 LYS   A CA  1 
ATOM   1868 C C   . LYS   A 1 253 ? 29.21636  -16.18671 -29.24902 1.000 65.70036 ? 449 LYS   A C   1 
ATOM   1869 O O   . LYS   A 1 253 ? 30.41675  -16.01579 -29.49206 1.000 73.02395 ? 449 LYS   A O   1 
ATOM   1870 C CB  . LYS   A 1 253 ? 28.78014  -17.54342 -27.20430 1.000 55.60323 ? 449 LYS   A CB  1 
ATOM   1871 C CG  . LYS   A 1 253 ? 30.18606  -18.07873 -26.98256 1.000 57.25435 ? 449 LYS   A CG  1 
ATOM   1872 C CD  . LYS   A 1 253 ? 30.15720  -19.47727 -26.38673 1.000 47.65153 ? 449 LYS   A CD  1 
ATOM   1873 C CE  . LYS   A 1 253 ? 30.45630  -19.44673 -24.89692 1.000 52.67359 ? 449 LYS   A CE  1 
ATOM   1874 N NZ  . LYS   A 1 253 ? 31.22110  -20.64655 -24.45458 1.000 47.53900 ? 449 LYS   A NZ  1 
ATOM   1875 N N   . THR   A 1 254 ? 28.32094  -16.41034 -30.21259 1.000 62.64152 ? 450 THR   A N   1 
ATOM   1876 C CA  . THR   A 1 254 ? 28.71952  -16.65436 -31.59463 1.000 64.02707 ? 450 THR   A CA  1 
ATOM   1877 C C   . THR   A 1 254 ? 28.22816  -15.58876 -32.56912 1.000 69.10698 ? 450 THR   A C   1 
ATOM   1878 O O   . THR   A 1 254 ? 28.36091  -15.77424 -33.78502 1.000 67.64009 ? 450 THR   A O   1 
ATOM   1879 C CB  . THR   A 1 254 ? 28.22857  -18.03221 -32.05181 1.000 62.47767 ? 450 THR   A CB  1 
ATOM   1880 O OG1 . THR   A 1 254 ? 26.81017  -17.99482 -32.25129 1.000 55.88945 ? 450 THR   A OG1 1 
ATOM   1881 C CG2 . THR   A 1 254 ? 28.56241  -19.09196 -31.01086 1.000 59.74742 ? 450 THR   A CG2 1 
ATOM   1882 N N   . GLU   A 1 255 ? 27.66396  -14.48453 -32.08167 1.000 66.81680 ? 451 GLU   A N   1 
ATOM   1883 C CA  . GLU   A 1 255 ? 27.21352  -13.38619 -32.93860 1.000 66.06513 ? 451 GLU   A CA  1 
ATOM   1884 C C   . GLU   A 1 255 ? 27.73953  -12.08021 -32.35006 1.000 67.80544 ? 451 GLU   A C   1 
ATOM   1885 O O   . GLU   A 1 255 ? 27.17982  -11.55759 -31.38130 1.000 66.72670 ? 451 GLU   A O   1 
ATOM   1886 C CB  . GLU   A 1 255 ? 25.69173  -13.36258 -33.06813 1.000 62.10371 ? 451 GLU   A CB  1 
ATOM   1887 C CG  . GLU   A 1 255 ? 25.07360  -14.67832 -33.51742 1.000 54.62050 ? 451 GLU   A CG  1 
ATOM   1888 C CD  . GLU   A 1 255 ? 25.20108  -14.90759 -35.01096 1.000 56.12173 ? 451 GLU   A CD  1 
ATOM   1889 O OE1 . GLU   A 1 255 ? 25.57267  -13.95835 -35.73253 1.000 57.34800 ? 451 GLU   A OE1 1 
ATOM   1890 O OE2 . GLU   A 1 255 ? 24.92926  -16.03940 -35.46404 1.000 58.78923 ? 451 GLU   A OE2 1 
ATOM   1891 N N   . SER   A 1 256 ? 28.81458  -11.55405 -32.94041 1.000 68.43115 ? 452 SER   A N   1 
ATOM   1892 C CA  . SER   A 1 256 ? 29.41031  -10.31878 -32.44268 1.000 70.31845 ? 452 SER   A CA  1 
ATOM   1893 C C   . SER   A 1 256 ? 28.58423  -9.09865  -32.83135 1.000 68.47808 ? 452 SER   A C   1 
ATOM   1894 O O   . SER   A 1 256 ? 28.45027  -8.15927  -32.03874 1.000 68.29116 ? 452 SER   A O   1 
ATOM   1895 C CB  . SER   A 1 256 ? 30.83973  -10.17958 -32.96575 1.000 72.13272 ? 452 SER   A CB  1 
ATOM   1896 O OG  . SER   A 1 256 ? 30.92426  -10.58765 -34.32022 1.000 70.49601 ? 452 SER   A OG  1 
ATOM   1897 N N   . ASP   A 1 257 ? 28.02693  -9.09341  -34.04507 1.000 62.61566 ? 453 ASP   A N   1 
ATOM   1898 C CA  . ASP   A 1 257 ? 27.21395  -7.96817  -34.49164 1.000 64.78749 ? 453 ASP   A CA  1 
ATOM   1899 C C   . ASP   A 1 257 ? 25.89722  -7.86589  -33.73504 1.000 67.19122 ? 453 ASP   A C   1 
ATOM   1900 O O   . ASP   A 1 257 ? 25.24605  -6.81693  -33.78766 1.000 67.80529 ? 453 ASP   A O   1 
ATOM   1901 C CB  . ASP   A 1 257 ? 26.93911  -8.07991  -35.99133 1.000 63.64447 ? 453 ASP   A CB  1 
ATOM   1902 C CG  . ASP   A 1 257 ? 27.78554  -7.12872  -36.80950 1.000 71.06679 ? 453 ASP   A CG  1 
ATOM   1903 O OD1 . ASP   A 1 257 ? 27.85233  -7.30358  -38.04413 1.000 77.51430 ? 453 ASP   A OD1 1 
ATOM   1904 O OD2 . ASP   A 1 257 ? 28.38329  -6.20549  -36.21750 1.000 67.13113 ? 453 ASP   A OD2 1 
ATOM   1905 N N   . ALA   A 1 258 ? 25.49284  -8.92392  -33.03756 1.000 64.18881 ? 454 ALA   A N   1 
ATOM   1906 C CA  . ALA   A 1 258 ? 24.24207  -8.92546  -32.28442 1.000 56.37475 ? 454 ALA   A CA  1 
ATOM   1907 C C   . ALA   A 1 258 ? 24.52000  -8.56798  -30.82491 1.000 53.62593 ? 454 ALA   A C   1 
ATOM   1908 O O   . ALA   A 1 258 ? 24.44296  -9.39606  -29.91592 1.000 51.53721 ? 454 ALA   A O   1 
ATOM   1909 C CB  . ALA   A 1 258 ? 23.55020  -10.27873 -32.41405 1.000 55.75146 ? 454 ALA   A CB  1 
ATOM   1910 N N   . ALA   A 1 259 ? 24.85973  -7.29685  -30.61856 1.000 52.27860 ? 455 ALA   A N   1 
ATOM   1911 C CA  . ALA   A 1 259 ? 25.07293  -6.78948  -29.27026 1.000 54.73692 ? 455 ALA   A CA  1 
ATOM   1912 C C   . ALA   A 1 259 ? 23.75961  -6.81436  -28.50242 1.000 52.96505 ? 455 ALA   A C   1 
ATOM   1913 O O   . ALA   A 1 259 ? 22.73543  -6.32126  -28.98422 1.000 56.21036 ? 455 ALA   A O   1 
ATOM   1914 C CB  . ALA   A 1 259 ? 25.63997  -5.37189  -29.31185 1.000 52.17085 ? 455 ALA   A CB  1 
ATOM   1915 N N   . LEU   A 1 260 ? 23.78599  -7.39338  -27.31016 1.000 45.55772 ? 456 LEU   A N   1 
ATOM   1916 C CA  . LEU   A 1 260 ? 22.57303  -7.62781  -26.54472 1.000 48.91998 ? 456 LEU   A CA  1 
ATOM   1917 C C   . LEU   A 1 260 ? 22.36793  -6.49746  -25.54345 1.000 49.30254 ? 456 LEU   A C   1 
ATOM   1918 O O   . LEU   A 1 260 ? 23.33255  -5.96255  -24.98825 1.000 45.34747 ? 456 LEU   A O   1 
ATOM   1919 C CB  . LEU   A 1 260 ? 22.64633  -8.97879  -25.83259 1.000 53.04836 ? 456 LEU   A CB  1 
ATOM   1920 C CG  . LEU   A 1 260 ? 21.36230  -9.50830  -25.19801 1.000 55.21427 ? 456 LEU   A CG  1 
ATOM   1921 C CD1 . LEU   A 1 260 ? 21.05083  -10.86580 -25.79694 1.000 54.33797 ? 456 LEU   A CD1 1 
ATOM   1922 C CD2 . LEU   A 1 260 ? 21.48859  -9.61135  -23.69965 1.000 52.44439 ? 456 LEU   A CD2 1 
ATOM   1923 N N   . HIS   A 1 261 ? 21.10618  -6.13492  -25.32546 1.000 42.21648 ? 457 HIS   A N   1 
ATOM   1924 C CA  . HIS   A 1 261 ? 20.78699  -4.97974  -24.49692 1.000 40.75157 ? 457 HIS   A CA  1 
ATOM   1925 C C   . HIS   A 1 261 ? 21.20257  -5.22892  -23.04734 1.000 42.70404 ? 457 HIS   A C   1 
ATOM   1926 O O   . HIS   A 1 261 ? 21.06027  -6.34789  -22.54396 1.000 49.21337 ? 457 HIS   A O   1 
ATOM   1927 C CB  . HIS   A 1 261 ? 19.29030  -4.67388  -24.57369 1.000 41.12581 ? 457 HIS   A CB  1 
ATOM   1928 C CG  . HIS   A 1 261 ? 18.90922  -3.34622  -23.99657 1.000 36.07039 ? 457 HIS   A CG  1 
ATOM   1929 N ND1 . HIS   A 1 261 ? 18.81399  -3.12364  -22.64011 1.000 37.93688 ? 457 HIS   A ND1 1 
ATOM   1930 C CD2 . HIS   A 1 261 ? 18.59710  -2.17113  -24.59298 1.000 39.68749 ? 457 HIS   A CD2 1 
ATOM   1931 C CE1 . HIS   A 1 261 ? 18.46124  -1.86880  -22.42505 1.000 41.59687 ? 457 HIS   A CE1 1 
ATOM   1932 N NE2 . HIS   A 1 261 ? 18.32280  -1.26917  -23.59370 1.000 41.24556 ? 457 HIS   A NE2 1 
ATOM   1933 N N   . PRO   A 1 262 ? 21.72598  -4.20953  -22.35500 1.000 43.36851 ? 458 PRO   A N   1 
ATOM   1934 C CA  . PRO   A 1 262 ? 22.17616  -4.42457  -20.96681 1.000 49.04622 ? 458 PRO   A CA  1 
ATOM   1935 C C   . PRO   A 1 262 ? 21.07378  -4.88150  -20.02651 1.000 40.09345 ? 458 PRO   A C   1 
ATOM   1936 O O   . PRO   A 1 262 ? 21.33288  -5.69428  -19.12998 1.000 39.89516 ? 458 PRO   A O   1 
ATOM   1937 C CB  . PRO   A 1 262 ? 22.73211  -3.05067  -20.56445 1.000 43.88095 ? 458 PRO   A CB  1 
ATOM   1938 C CG  . PRO   A 1 262 ? 23.08497  -2.38665  -21.85040 1.000 45.68425 ? 458 PRO   A CG  1 
ATOM   1939 C CD  . PRO   A 1 262 ? 22.08438  -2.87153  -22.85652 1.000 47.32571 ? 458 PRO   A CD  1 
ATOM   1940 N N   . LEU   A 1 263 ? 19.85126  -4.37132  -20.19173 1.000 39.57027 ? 459 LEU   A N   1 
ATOM   1941 C CA  . LEU   A 1 263 ? 18.74469  -4.84336  -19.36549 1.000 38.35434 ? 459 LEU   A CA  1 
ATOM   1942 C C   . LEU   A 1 263 ? 18.47433  -6.32153  -19.61142 1.000 35.79088 ? 459 LEU   A C   1 
ATOM   1943 O O   . LEU   A 1 263 ? 18.22893  -7.08261  -18.66760 1.000 36.60873 ? 459 LEU   A O   1 
ATOM   1944 C CB  . LEU   A 1 263 ? 17.48904  -4.01358  -19.63647 1.000 41.69136 ? 459 LEU   A CB  1 
ATOM   1945 C CG  . LEU   A 1 263 ? 16.21292  -4.46461  -18.91892 1.000 37.15504 ? 459 LEU   A CG  1 
ATOM   1946 C CD1 . LEU   A 1 263 ? 16.37370  -4.36836  -17.40889 1.000 32.88476 ? 459 LEU   A CD1 1 
ATOM   1947 C CD2 . LEU   A 1 263 ? 15.01484  -3.65372  -19.38563 1.000 30.20893 ? 459 LEU   A CD2 1 
ATOM   1948 N N   . LEU   A 1 264 ? 18.52500  -6.74836  -20.87548 1.000 36.56427 ? 460 LEU   A N   1 
ATOM   1949 C CA  . LEU   A 1 264 ? 18.33658  -8.16094  -21.18396 1.000 38.98578 ? 460 LEU   A CA  1 
ATOM   1950 C C   . LEU   A 1 264 ? 19.53463  -8.99258  -20.74476 1.000 42.25837 ? 460 LEU   A C   1 
ATOM   1951 O O   . LEU   A 1 264 ? 19.37388  -10.16885 -20.39880 1.000 40.37902 ? 460 LEU   A O   1 
ATOM   1952 C CB  . LEU   A 1 264 ? 18.07354  -8.34217  -22.67882 1.000 36.34383 ? 460 LEU   A CB  1 
ATOM   1953 C CG  . LEU   A 1 264 ? 16.96181  -7.47489  -23.27672 1.000 36.02450 ? 460 LEU   A CG  1 
ATOM   1954 C CD1 . LEU   A 1 264 ? 16.62693  -7.93054  -24.68456 1.000 34.68835 ? 460 LEU   A CD1 1 
ATOM   1955 C CD2 . LEU   A 1 264 ? 15.71592  -7.48961  -22.39984 1.000 34.27062 ? 460 LEU   A CD2 1 
ATOM   1956 N N   . GLN   A 1 265 ? 20.73671  -8.40691  -20.75653 1.000 41.62414 ? 461 GLN   A N   1 
ATOM   1957 C CA  . GLN   A 1 265 ? 21.89563  -9.08896  -20.18810 1.000 43.09463 ? 461 GLN   A CA  1 
ATOM   1958 C C   . GLN   A 1 265 ? 21.67858  -9.38590  -18.71239 1.000 38.71534 ? 461 GLN   A C   1 
ATOM   1959 O O   . GLN   A 1 265 ? 21.98041  -10.48719 -18.23796 1.000 38.05896 ? 461 GLN   A O   1 
ATOM   1960 C CB  . GLN   A 1 265 ? 23.15838  -8.24342  -20.37629 1.000 46.14004 ? 461 GLN   A CB  1 
ATOM   1961 C CG  . GLN   A 1 265 ? 24.08932  -8.71260  -21.48632 1.000 57.00640 ? 461 GLN   A CG  1 
ATOM   1962 C CD  . GLN   A 1 265 ? 24.77827  -7.56490  -22.20532 1.000 62.25874 ? 461 GLN   A CD  1 
ATOM   1963 O OE1 . GLN   A 1 265 ? 24.48672  -6.39483  -21.95782 1.000 60.11700 ? 461 GLN   A OE1 1 
ATOM   1964 N NE2 . GLN   A 1 265 ? 25.70318  -7.89807  -23.09920 1.000 52.44187 ? 461 GLN   A NE2 1 
ATOM   1965 N N   . GLU   A 1 266 ? 21.14689  -8.41198  -17.97329 1.000 37.34384 ? 462 GLU   A N   1 
ATOM   1966 C CA  . GLU   A 1 266 ? 20.93004  -8.58924  -16.54383 1.000 38.10212 ? 462 GLU   A CA  1 
ATOM   1967 C C   . GLU   A 1 266 ? 19.83133  -9.60550  -16.25954 1.000 42.12146 ? 462 GLU   A C   1 
ATOM   1968 O O   . GLU   A 1 266 ? 19.90850  -10.33711 -15.26546 1.000 42.00323 ? 462 GLU   A O   1 
ATOM   1969 C CB  . GLU   A 1 266 ? 20.59384  -7.24076  -15.91099 1.000 42.79370 ? 462 GLU   A CB  1 
ATOM   1970 C CG  . GLU   A 1 266 ? 20.34229  -7.28216  -14.42104 1.000 51.95261 ? 462 GLU   A CG  1 
ATOM   1971 C CD  . GLU   A 1 266 ? 19.85955  -5.95116  -13.89193 1.000 52.86944 ? 462 GLU   A CD  1 
ATOM   1972 O OE1 . GLU   A 1 266 ? 20.53575  -4.93147  -14.14351 1.000 55.16053 ? 462 GLU   A OE1 1 
ATOM   1973 O OE2 . GLU   A 1 266 ? 18.80570  -5.92228  -13.22440 1.000 54.40145 ? 462 GLU   A OE2 1 
ATOM   1974 N N   . ILE   A 1 267 ? 18.81311  -9.67532  -17.11915 1.000 38.34216 ? 463 ILE   A N   1 
ATOM   1975 C CA  . ILE   A 1 267 ? 17.69625  -10.58452 -16.87748 1.000 37.86864 ? 463 ILE   A CA  1 
ATOM   1976 C C   . ILE   A 1 267 ? 18.12184  -12.02979 -17.11157 1.000 32.43403 ? 463 ILE   A C   1 
ATOM   1977 O O   . ILE   A 1 267 ? 17.85190  -12.91425 -16.29080 1.000 32.38065 ? 463 ILE   A O   1 
ATOM   1978 C CB  . ILE   A 1 267 ? 16.49216  -10.19750 -17.75538 1.000 37.25072 ? 463 ILE   A CB  1 
ATOM   1979 C CG1 . ILE   A 1 267 ? 15.82612  -8.93030  -17.21429 1.000 34.95683 ? 463 ILE   A CG1 1 
ATOM   1980 C CG2 . ILE   A 1 267 ? 15.48592  -11.33753 -17.82317 1.000 29.77001 ? 463 ILE   A CG2 1 
ATOM   1981 C CD1 . ILE   A 1 267 ? 14.94123  -8.23079  -18.21999 1.000 33.94531 ? 463 ILE   A CD1 1 
ATOM   1982 N N   . TYR   A 1 268 ? 18.80084  -12.29063 -18.23079 1.000 31.81950 ? 464 TYR   A N   1 
ATOM   1983 C CA  . TYR   A 1 268 ? 19.19047  -13.65570 -18.56581 1.000 36.60798 ? 464 TYR   A CA  1 
ATOM   1984 C C   . TYR   A 1 268 ? 20.35630  -14.16086 -17.72461 1.000 41.61854 ? 464 TYR   A C   1 
ATOM   1985 O O   . TYR   A 1 268 ? 20.54557  -15.37792 -17.62292 1.000 43.05080 ? 464 TYR   A O   1 
ATOM   1986 C CB  . TYR   A 1 268 ? 19.55150  -13.74958 -20.04797 1.000 34.91138 ? 464 TYR   A CB  1 
ATOM   1987 C CG  . TYR   A 1 268 ? 18.35651  -13.76577 -20.97306 1.000 33.97661 ? 464 TYR   A CG  1 
ATOM   1988 C CD1 . TYR   A 1 268 ? 17.45634  -14.82397 -20.95970 1.000 34.61189 ? 464 TYR   A CD1 1 
ATOM   1989 C CD2 . TYR   A 1 268 ? 18.13054  -12.72386 -21.86210 1.000 34.83110 ? 464 TYR   A CD2 1 
ATOM   1990 C CE1 . TYR   A 1 268 ? 16.36261  -14.84132 -21.80606 1.000 36.68701 ? 464 TYR   A CE1 1 
ATOM   1991 C CE2 . TYR   A 1 268 ? 17.04192  -12.73218 -22.71125 1.000 38.83738 ? 464 TYR   A CE2 1 
ATOM   1992 C CZ  . TYR   A 1 268 ? 16.16190  -13.79201 -22.67943 1.000 28.40048 ? 464 TYR   A CZ  1 
ATOM   1993 O OH  . TYR   A 1 268 ? 15.07987  -13.79951 -23.52620 1.000 35.43873 ? 464 TYR   A OH  1 
ATOM   1994 N N   . ARG   A 1 269 ? 21.13696  -13.26467 -17.12584 1.000 41.36582 ? 465 ARG   A N   1 
ATOM   1995 C CA  . ARG   A 1 269 ? 22.31226  -13.67761 -16.36975 1.000 44.99126 ? 465 ARG   A CA  1 
ATOM   1996 C C   . ARG   A 1 269 ? 21.90179  -14.44881 -15.12059 1.000 46.08123 ? 465 ARG   A C   1 
ATOM   1997 O O   . ARG   A 1 269 ? 21.04216  -13.99953 -14.35619 1.000 48.82668 ? 465 ARG   A O   1 
ATOM   1998 C CB  . ARG   A 1 269 ? 23.14860  -12.45671 -15.99012 1.000 45.85499 ? 465 ARG   A CB  1 
ATOM   1999 C CG  . ARG   A 1 269 ? 24.52413  -12.78277 -15.43015 1.000 46.25638 ? 465 ARG   A CG  1 
ATOM   2000 C CD  . ARG   A 1 269 ? 25.41457  -11.54882 -15.42188 1.000 53.92844 ? 465 ARG   A CD  1 
ATOM   2001 N NE  . ARG   A 1 269 ? 24.83404  -10.46537 -14.63680 1.000 61.77115 ? 465 ARG   A NE  1 
ATOM   2002 C CZ  . ARG   A 1 269 ? 24.67804  -9.22240  -15.07314 1.000 57.82665 ? 465 ARG   A CZ  1 
ATOM   2003 N NH1 . ARG   A 1 269 ? 25.05456  -8.86413  -16.29015 1.000 50.55235 ? 465 ARG   A NH1 1 
ATOM   2004 N NH2 . ARG   A 1 269 ? 24.12858  -8.31635  -14.26886 1.000 48.80907 ? 465 ARG   A NH2 1 
ATOM   2005 N N   . ASP   A 1 270 ? 22.51612  -15.61884 -14.92450 1.000 42.09900 ? 466 ASP   A N   1 
ATOM   2006 C CA  . ASP   A 1 270 ? 22.28034  -16.45869 -13.74681 1.000 40.70446 ? 466 ASP   A CA  1 
ATOM   2007 C C   . ASP   A 1 270 ? 20.82442  -16.91330 -13.66412 1.000 48.81474 ? 466 ASP   A C   1 
ATOM   2008 O O   . ASP   A 1 270 ? 20.23661  -16.98355 -12.58289 1.000 49.38878 ? 466 ASP   A O   1 
ATOM   2009 C CB  . ASP   A 1 270 ? 22.69787  -15.74114 -12.46032 1.000 42.52282 ? 466 ASP   A CB  1 
ATOM   2010 C CG  . ASP   A 1 270 ? 24.15307  -15.32185 -12.47383 1.000 50.04887 ? 466 ASP   A CG  1 
ATOM   2011 O OD1 . ASP   A 1 270 ? 24.42940  -14.11910 -12.27838 1.000 53.62797 ? 466 ASP   A OD1 1 
ATOM   2012 O OD2 . ASP   A 1 270 ? 25.02008  -16.19655 -12.67637 1.000 47.67891 ? 466 ASP   A OD2 1 
ATOM   2013 N N   . MET   A 1 271 ? 20.23849  -17.22864 -14.81401 1.000 44.03439 ? 467 MET   A N   1 
ATOM   2014 C CA  . MET   A 1 271 ? 18.86479  -17.71453 -14.85978 1.000 48.97992 ? 467 MET   A CA  1 
ATOM   2015 C C   . MET   A 1 271 ? 18.82177  -19.23925 -14.83446 1.000 48.88931 ? 467 MET   A C   1 
ATOM   2016 O O   . MET   A 1 271 ? 18.61195  -19.88160 -15.86367 1.000 55.83460 ? 467 MET   A O   1 
ATOM   2017 C CB  . MET   A 1 271 ? 18.14920  -17.18814 -16.10485 1.000 44.60968 ? 467 MET   A CB  1 
ATOM   2018 C CG  . MET   A 1 271 ? 16.71482  -16.75907 -15.85407 1.000 46.65884 ? 467 MET   A CG  1 
ATOM   2019 S SD  . MET   A 1 271 ? 15.72108  -16.73828 -17.35761 1.000 51.13089 ? 467 MET   A SD  1 
ATOM   2020 C CE  . MET   A 1 271 ? 15.58943  -14.97876 -17.65151 1.000 46.47401 ? 467 MET   A CE  1 
ATOM   2021 N N   . PRO   B 2 7   ? 24.46053  -2.00511  -7.95131  1.000 80.83900 ? 141 PRO   B N   1 
ATOM   2022 C CA  . PRO   B 2 7   ? 23.05014  -1.72112  -8.24002  1.000 80.32867 ? 141 PRO   B CA  1 
ATOM   2023 C C   . PRO   B 2 7   ? 22.67366  -2.09456  -9.67458  1.000 77.32797 ? 141 PRO   B C   1 
ATOM   2024 O O   . PRO   B 2 7   ? 23.41996  -1.78786  -10.60437 1.000 78.53950 ? 141 PRO   B O   1 
ATOM   2025 C CB  . PRO   B 2 7   ? 22.94249  -0.21000  -8.00746  1.000 75.30747 ? 141 PRO   B CB  1 
ATOM   2026 C CG  . PRO   B 2 7   ? 24.33346  0.30284   -8.16062  1.000 77.95403 ? 141 PRO   B CG  1 
ATOM   2027 C CD  . PRO   B 2 7   ? 25.21556  -0.78237  -7.63072  1.000 83.80373 ? 141 PRO   B CD  1 
ATOM   2028 N N   . SER   B 2 8   ? 21.52443  -2.74171  -9.84325  1.000 71.32190 ? 142 SER   B N   1 
ATOM   2029 C CA  . SER   B 2 8   ? 21.13360  -3.34893  -11.10695 1.000 56.99258 ? 142 SER   B CA  1 
ATOM   2030 C C   . SER   B 2 8   ? 20.07173  -2.51742  -11.82120 1.000 53.28892 ? 142 SER   B C   1 
ATOM   2031 O O   . SER   B 2 8   ? 19.37085  -1.70430  -11.21540 1.000 53.25370 ? 142 SER   B O   1 
ATOM   2032 C CB  . SER   B 2 8   ? 20.61532  -4.77010  -10.87339 1.000 61.72285 ? 142 SER   B CB  1 
ATOM   2033 O OG  . SER   B 2 8   ? 19.57762  -4.78571  -9.90905  1.000 58.90302 ? 142 SER   B OG  1 
ATOM   2034 N N   . LEU   B 2 9   ? 19.95231  -2.75060  -13.13317 1.000 49.57009 ? 143 LEU   B N   1 
ATOM   2035 C CA  . LEU   B 2 9   ? 19.02627  -1.97296  -13.95332 1.000 47.56019 ? 143 LEU   B CA  1 
ATOM   2036 C C   . LEU   B 2 9   ? 17.56962  -2.28578  -13.63105 1.000 50.99832 ? 143 LEU   B C   1 
ATOM   2037 O O   . LEU   B 2 9   ? 16.71815  -1.39170  -13.70352 1.000 48.30693 ? 143 LEU   B O   1 
ATOM   2038 C CB  . LEU   B 2 9   ? 19.30034  -2.22146  -15.43699 1.000 48.41497 ? 143 LEU   B CB  1 
ATOM   2039 C CG  . LEU   B 2 9   ? 20.72200  -1.94344  -15.92908 1.000 52.12643 ? 143 LEU   B CG  1 
ATOM   2040 C CD1 . LEU   B 2 9   ? 20.92154  -2.48990  -17.33446 1.000 47.21397 ? 143 LEU   B CD1 1 
ATOM   2041 C CD2 . LEU   B 2 9   ? 21.01742  -0.45290  -15.88612 1.000 45.34311 ? 143 LEU   B CD2 1 
ATOM   2042 N N   . LEU   B 2 10  ? 17.25775  -3.54077  -13.29258 1.000 49.91953 ? 144 LEU   B N   1 
ATOM   2043 C CA  . LEU   B 2 10  ? 15.89234  -3.87530  -12.89844 1.000 46.16217 ? 144 LEU   B CA  1 
ATOM   2044 C C   . LEU   B 2 10  ? 15.47637  -3.11545  -11.64738 1.000 49.41464 ? 144 LEU   B C   1 
ATOM   2045 O O   . LEU   B 2 10  ? 14.29718  -2.78058  -11.48607 1.000 44.11451 ? 144 LEU   B O   1 
ATOM   2046 C CB  . LEU   B 2 10  ? 15.75672  -5.38200  -12.67137 1.000 48.35073 ? 144 LEU   B CB  1 
ATOM   2047 C CG  . LEU   B 2 10  ? 15.44724  -6.25291  -13.89104 1.000 47.43062 ? 144 LEU   B CG  1 
ATOM   2048 C CD1 . LEU   B 2 10  ? 15.60911  -7.72638  -13.54826 1.000 45.91148 ? 144 LEU   B CD1 1 
ATOM   2049 C CD2 . LEU   B 2 10  ? 14.04498  -5.97485  -14.41366 1.000 42.69184 ? 144 LEU   B CD2 1 
ATOM   2050 N N   . LYS   B 2 11  ? 16.42870  -2.83034  -10.75623 1.000 48.38308 ? 145 LYS   B N   1 
ATOM   2051 C CA  . LYS   B 2 11  ? 16.12399  -2.03092  -9.57575  1.000 50.10576 ? 145 LYS   B CA  1 
ATOM   2052 C C   . LYS   B 2 11  ? 15.77780  -0.59362  -9.94384  1.000 46.96477 ? 145 LYS   B C   1 
ATOM   2053 O O   . LYS   B 2 11  ? 15.02517  0.06328   -9.21622  1.000 51.62030 ? 145 LYS   B O   1 
ATOM   2054 C CB  . LYS   B 2 11  ? 17.30372  -2.06465  -8.60458  1.000 53.29822 ? 145 LYS   B CB  1 
ATOM   2055 C CG  . LYS   B 2 11  ? 17.48473  -3.40088  -7.90861  1.000 48.63205 ? 145 LYS   B CG  1 
ATOM   2056 C CD  . LYS   B 2 11  ? 18.00803  -3.22994  -6.49648  1.000 49.10775 ? 145 LYS   B CD  1 
ATOM   2057 C CE  . LYS   B 2 11  ? 18.98264  -4.33673  -6.13689  1.000 60.43398 ? 145 LYS   B CE  1 
ATOM   2058 N NZ  . LYS   B 2 11  ? 18.90468  -4.68701  -4.69284  1.000 61.03161 ? 145 LYS   B NZ  1 
ATOM   2059 N N   . LYS   B 2 12  ? 16.31009  -0.08994  -11.06240 1.000 50.39489 ? 146 LYS   B N   1 
ATOM   2060 C CA  . LYS   B 2 12  ? 15.98364  1.26891   -11.49102 1.000 55.98282 ? 146 LYS   B CA  1 
ATOM   2061 C C   . LYS   B 2 12  ? 14.51824  1.38058   -11.88576 1.000 50.25460 ? 146 LYS   B C   1 
ATOM   2062 O O   . LYS   B 2 12  ? 13.84989  2.36460   -11.54773 1.000 51.69664 ? 146 LYS   B O   1 
ATOM   2063 C CB  . LYS   B 2 12  ? 16.86831  1.70315   -12.66510 1.000 49.74581 ? 146 LYS   B CB  1 
ATOM   2064 C CG  . LYS   B 2 12  ? 18.27722  2.19717   -12.33198 1.000 59.02274 ? 146 LYS   B CG  1 
ATOM   2065 C CD  . LYS   B 2 12  ? 18.94018  1.39713   -11.23884 1.000 57.64459 ? 146 LYS   B CD  1 
ATOM   2066 C CE  . LYS   B 2 12  ? 20.43630  1.59600   -11.23828 1.000 64.96940 ? 146 LYS   B CE  1 
ATOM   2067 N NZ  . LYS   B 2 12  ? 21.07214  0.55901   -10.39444 1.000 63.10848 ? 146 LYS   B NZ  1 
ATOM   2068 N N   . LEU   B 2 13  ? 14.00698  0.38730   -12.61554 1.000 46.19010 ? 147 LEU   B N   1 
ATOM   2069 C CA  . LEU   B 2 13  ? 12.60536  0.40813   -13.01407 1.000 46.30218 ? 147 LEU   B CA  1 
ATOM   2070 C C   . LEU   B 2 13  ? 11.68079  0.22864   -11.81837 1.000 46.06018 ? 147 LEU   B C   1 
ATOM   2071 O O   . LEU   B 2 13  ? 10.56280  0.75576   -11.81724 1.000 51.78625 ? 147 LEU   B O   1 
ATOM   2072 C CB  . LEU   B 2 13  ? 12.34380  -0.67787  -14.05672 1.000 46.06818 ? 147 LEU   B CB  1 
ATOM   2073 C CG  . LEU   B 2 13  ? 13.40125  -0.80366  -15.15509 1.000 41.35076 ? 147 LEU   B CG  1 
ATOM   2074 C CD1 . LEU   B 2 13  ? 13.28796  -2.14374  -15.86556 1.000 39.81931 ? 147 LEU   B CD1 1 
ATOM   2075 C CD2 . LEU   B 2 13  ? 13.28950  0.34569   -16.14709 1.000 40.34009 ? 147 LEU   B CD2 1 
ATOM   2076 N N   . LEU   B 2 14  ? 12.12606  -0.50273  -10.79445 1.000 43.00902 ? 148 LEU   B N   1 
ATOM   2077 C CA  . LEU   B 2 14  ? 11.28915  -0.72113  -9.62072  1.000 45.52998 ? 148 LEU   B CA  1 
ATOM   2078 C C   . LEU   B 2 14  ? 11.33028  0.45547   -8.65386  1.000 47.96322 ? 148 LEU   B C   1 
ATOM   2079 O O   . LEU   B 2 14  ? 10.32626  0.73967   -7.99147  1.000 47.02673 ? 148 LEU   B O   1 
ATOM   2080 C CB  . LEU   B 2 14  ? 11.70930  -2.00549  -8.90563  1.000 37.36767 ? 148 LEU   B CB  1 
ATOM   2081 C CG  . LEU   B 2 14  ? 11.34056  -3.30099  -9.62905  1.000 42.29485 ? 148 LEU   B CG  1 
ATOM   2082 C CD1 . LEU   B 2 14  ? 12.36408  -4.38469  -9.35001  1.000 43.73965 ? 148 LEU   B CD1 1 
ATOM   2083 C CD2 . LEU   B 2 14  ? 9.94800   -3.75602  -9.22121  1.000 42.16430 ? 148 LEU   B CD2 1 
ATOM   2084 N N   . LEU   B 2 15  ? 12.46482  1.14687   -8.55777  1.000 48.84460 ? 149 LEU   B N   1 
ATOM   2085 C CA  . LEU   B 2 15  ? 12.58805  2.29641   -7.67002  1.000 54.70655 ? 149 LEU   B CA  1 
ATOM   2086 C C   . LEU   B 2 15  ? 11.99132  3.56946   -8.25662  1.000 55.94374 ? 149 LEU   B C   1 
ATOM   2087 O O   . LEU   B 2 15  ? 11.98407  4.60020   -7.57471  1.000 58.84272 ? 149 LEU   B O   1 
ATOM   2088 C CB  . LEU   B 2 15  ? 14.05930  2.53341   -7.31674  1.000 48.53445 ? 149 LEU   B CB  1 
ATOM   2089 C CG  . LEU   B 2 15  ? 14.69121  1.52888   -6.35082  1.000 51.53281 ? 149 LEU   B CG  1 
ATOM   2090 C CD1 . LEU   B 2 15  ? 16.19165  1.75486   -6.24227  1.000 52.83819 ? 149 LEU   B CD1 1 
ATOM   2091 C CD2 . LEU   B 2 15  ? 14.03176  1.60988   -4.98325  1.000 54.23562 ? 149 LEU   B CD2 1 
ATOM   2092 N N   . ALA   B 2 16  ? 11.49508  3.52769   -9.48907  1.000 51.29023 ? 150 ALA   B N   1 
ATOM   2093 C CA  . ALA   B 2 16  ? 10.89726  4.70147   -10.11451 1.000 59.70386 ? 150 ALA   B CA  1 
ATOM   2094 C C   . ALA   B 2 16  ? 9.37542   4.59734   -10.12772 1.000 61.55087 ? 150 ALA   B C   1 
ATOM   2095 O O   . ALA   B 2 16  ? 8.69987   5.10847   -9.23398  1.000 62.25799 ? 150 ALA   B O   1 
ATOM   2096 C CB  . ALA   B 2 16  ? 11.42981  4.87860   -11.52811 1.000 59.08763 ? 150 ALA   B CB  1 
HETATM 2097 C C1  . PGO   C 3 .   ? 3.62102   -5.35096  -31.35919 1.000 44.20568 ? 501 PGO   A C1  1 
HETATM 2098 C C2  . PGO   C 3 .   ? 4.76169   -4.62858  -30.64504 1.000 50.64811 ? 501 PGO   A C2  1 
HETATM 2099 C C3  . PGO   C 3 .   ? 4.18161   -3.62441  -29.65108 1.000 48.18233 ? 501 PGO   A C3  1 
HETATM 2100 O O1  . PGO   C 3 .   ? 3.49118   -4.84853  -32.66075 1.000 48.97428 ? 501 PGO   A O1  1 
HETATM 2101 O O2  . PGO   C 3 .   ? 5.55782   -3.95879  -31.58317 1.000 42.78651 ? 501 PGO   A O2  1 
HETATM 2102 C C12 . A1LZ0 D 4 .   ? 17.54785  -10.97516 -26.48009 1.000 44.53577 ? 502 A1LZ0 A C12 1 
HETATM 2103 C C13 . A1LZ0 D 4 .   ? 17.35682  -14.93776 -28.78175 1.000 38.04413 ? 502 A1LZ0 A C13 1 
HETATM 2104 C C14 . A1LZ0 D 4 .   ? 15.45907  -12.37957 -33.60775 1.000 37.37285 ? 502 A1LZ0 A C14 1 
HETATM 2105 C C15 . A1LZ0 D 4 .   ? 15.22157  -12.49893 -35.10963 1.000 39.28561 ? 502 A1LZ0 A C15 1 
HETATM 2106 C C16 . A1LZ0 D 4 .   ? 13.84964  -12.91162 -35.63232 1.000 34.64135 ? 502 A1LZ0 A C16 1 
HETATM 2107 C C17 . A1LZ0 D 4 .   ? 12.71713  -13.20378 -34.65361 1.000 40.09002 ? 502 A1LZ0 A C17 1 
HETATM 2108 N N21 . A1LZ0 D 4 .   ? 12.17366  -12.03127 -30.34798 1.000 38.34313 ? 502 A1LZ0 A N21 1 
HETATM 2109 N N23 . A1LZ0 D 4 .   ? 14.57494  -12.55280 -31.20032 1.000 39.84680 ? 502 A1LZ0 A N23 1 
HETATM 2110 C C26 . A1LZ0 D 4 .   ? 6.78309   -8.60326  -28.86540 1.000 27.73007 ? 502 A1LZ0 A C26 1 
HETATM 2111 C C29 . A1LZ0 D 4 .   ? 8.74317   -9.84483  -27.85984 1.000 31.51562 ? 502 A1LZ0 A C29 1 
HETATM 2112 C C01 . A1LZ0 D 4 .   ? 11.39387  -11.75371 -29.15005 1.000 32.02191 ? 502 A1LZ0 A C01 1 
HETATM 2113 C C02 . A1LZ0 D 4 .   ? 12.06390  -11.70376 -27.83321 1.000 29.75768 ? 502 A1LZ0 A C02 1 
HETATM 2114 C C03 . A1LZ0 D 4 .   ? 13.51016  -11.94557 -27.74463 1.000 28.84877 ? 502 A1LZ0 A C03 1 
HETATM 2115 C C04 . A1LZ0 D 4 .   ? 14.32069  -12.23964 -29.01959 1.000 38.61722 ? 502 A1LZ0 A C04 1 
HETATM 2116 C C05 . A1LZ0 D 4 .   ? 13.67271  -12.27693 -30.25319 1.000 37.63455 ? 502 A1LZ0 A C05 1 
HETATM 2117 C C06 . A1LZ0 D 4 .   ? 15.65773  -12.49551 -29.25617 1.000 34.40893 ? 502 A1LZ0 A C06 1 
HETATM 2118 C C08 . A1LZ0 D 4 .   ? 14.16530  -11.87914 -26.36607 1.000 32.42593 ? 502 A1LZ0 A C08 1 
HETATM 2119 C C09 . A1LZ0 D 4 .   ? 16.78234  -12.56738 -28.22599 1.000 36.20654 ? 502 A1LZ0 A C09 1 
HETATM 2120 C C10 . A1LZ0 D 4 .   ? 17.34742  -11.17271 -27.97957 1.000 42.53600 ? 502 A1LZ0 A C10 1 
HETATM 2121 C C11 . A1LZ0 D 4 .   ? 17.88378  -13.50318 -28.72569 1.000 37.54403 ? 502 A1LZ0 A C11 1 
HETATM 2122 C C18 . A1LZ0 D 4 .   ? 12.95559  -13.08540 -33.15164 1.000 35.22382 ? 502 A1LZ0 A C18 1 
HETATM 2123 C C19 . A1LZ0 D 4 .   ? 14.32851  -12.67659 -32.62667 1.000 40.86531 ? 502 A1LZ0 A C19 1 
HETATM 2124 C C27 . A1LZ0 D 4 .   ? 4.92016   -8.22292  -27.32233 1.000 34.70781 ? 502 A1LZ0 A C27 1 
HETATM 2125 C C28 . A1LZ0 D 4 .   ? 9.40456   -11.21673 -27.99472 1.000 30.72294 ? 502 A1LZ0 A C28 1 
HETATM 2126 C C31 . A1LZ0 D 4 .   ? 8.30981   -10.06506 -30.26259 1.000 39.90932 ? 502 A1LZ0 A C31 1 
HETATM 2127 C C32 . A1LZ0 D 4 .   ? 9.74632   -10.55365 -30.30196 1.000 35.49891 ? 502 A1LZ0 A C32 1 
HETATM 2128 C C35 . A1LZ0 D 4 .   ? 3.98500   -9.10735  -28.14394 1.000 29.58283 ? 502 A1LZ0 A C35 1 
HETATM 2129 C C36 . A1LZ0 D 4 .   ? 4.63908   -6.74646  -27.59613 1.000 37.46924 ? 502 A1LZ0 A C36 1 
HETATM 2130 C C37 . A1LZ0 D 4 .   ? 4.65096   -8.49382  -25.84247 1.000 28.75242 ? 502 A1LZ0 A C37 1 
HETATM 2131 F F20 . A1LZ0 D 4 .   ? 13.63208  -13.01905 -36.97428 1.000 46.26387 ? 502 A1LZ0 A F20 1 
HETATM 2132 N N07 . A1LZ0 D 4 .   ? 9.97256   -11.52313 -29.27694 1.000 34.18634 ? 502 A1LZ0 A N07 1 
HETATM 2133 N N22 . A1LZ0 D 4 .   ? 15.82124  -12.68629 -30.57831 1.000 38.78452 ? 502 A1LZ0 A N22 1 
HETATM 2134 N N30 . A1LZ0 D 4 .   ? 8.02331   -9.31749  -29.03341 1.000 34.83077 ? 502 A1LZ0 A N30 1 
HETATM 2135 O O24 . A1LZ0 D 4 .   ? 14.62933  -12.91235 -25.81678 1.000 40.14638 ? 502 A1LZ0 A O24 1 
HETATM 2136 O O25 . A1LZ0 D 4 .   ? 14.23859  -10.76725 -25.77845 1.000 36.79249 ? 502 A1LZ0 A O25 1 
HETATM 2137 O O33 . A1LZ0 D 4 .   ? 6.27119   -8.11789  -29.81843 1.000 36.42694 ? 502 A1LZ0 A O33 1 
HETATM 2138 O O34 . A1LZ0 D 4 .   ? 6.26978   -8.52090  -27.56069 1.000 36.15498 ? 502 A1LZ0 A O34 1 
HETATM 2139 O O   . HOH   E 5 .   ? 14.86381  5.33085   -42.01500 1.000 60.46486 ? 601 HOH   A O   1 
HETATM 2140 O O   . HOH   E 5 .   ? -0.21610  -27.08671 -23.47888 1.000 47.29863 ? 602 HOH   A O   1 
HETATM 2141 O O   . HOH   E 5 .   ? -2.01091  -9.72554  -24.71194 1.000 37.48611 ? 603 HOH   A O   1 
HETATM 2142 O O   . HOH   E 5 .   ? 29.31237  -16.49833 -23.43618 1.000 45.03757 ? 604 HOH   A O   1 
HETATM 2143 O O   . HOH   E 5 .   ? 8.50936   -1.25436  -6.29443  1.000 53.14522 ? 605 HOH   A O   1 
HETATM 2144 O O   . HOH   E 5 .   ? 1.88321   -3.11026  -5.60549  1.000 37.15328 ? 606 HOH   A O   1 
HETATM 2145 O O   . HOH   E 5 .   ? 19.36640  2.57617   -37.88628 1.000 62.20285 ? 607 HOH   A O   1 
HETATM 2146 O O   . HOH   E 5 .   ? -7.60698  -9.58817  -42.52798 1.000 58.52848 ? 608 HOH   A O   1 
HETATM 2147 O O   . HOH   E 5 .   ? 33.30567  -21.95966 -24.00300 1.000 40.33157 ? 609 HOH   A O   1 
HETATM 2148 O O   . HOH   E 5 .   ? 1.56356   -25.15880 -13.75730 1.000 37.71868 ? 610 HOH   A O   1 
HETATM 2149 O O   . HOH   E 5 .   ? 25.38189  -18.88235 -34.14455 1.000 53.10095 ? 611 HOH   A O   1 
HETATM 2150 O O   . HOH   E 5 .   ? 11.77413  -20.90256 -26.86464 1.000 39.46677 ? 612 HOH   A O   1 
HETATM 2151 O O   . HOH   E 5 .   ? 18.782    1.120     -30.796   1.000 55.37213 ? 613 HOH   A O   1 
HETATM 2152 O O   . HOH   E 5 .   ? -4.14631  -0.87313  -23.31800 1.000 44.21030 ? 614 HOH   A O   1 
HETATM 2153 O O   . HOH   E 5 .   ? 0.97626   -6.87142  -24.59838 1.000 43.82130 ? 615 HOH   A O   1 
HETATM 2154 O O   . HOH   E 5 .   ? -10.69164 -22.95959 -29.99184 1.000 48.13775 ? 616 HOH   A O   1 
HETATM 2155 O O   . HOH   E 5 .   ? 11.00354  -19.58380 -4.29082  1.000 37.79618 ? 617 HOH   A O   1 
HETATM 2156 O O   . HOH   E 5 .   ? -12.33353 -21.79634 -12.85608 1.000 38.64808 ? 618 HOH   A O   1 
HETATM 2157 O O   . HOH   E 5 .   ? 7.80382   -14.29136 -11.25444 1.000 23.81268 ? 619 HOH   A O   1 
HETATM 2158 O O   . HOH   E 5 .   ? 8.27649   -18.79098 -37.87129 1.000 43.97053 ? 620 HOH   A O   1 
HETATM 2159 O O   . HOH   E 5 .   ? 11.76136  -23.79409 -27.61838 1.000 39.87407 ? 621 HOH   A O   1 
HETATM 2160 O O   . HOH   E 5 .   ? 5.61473   -20.15815 -14.31542 1.000 43.81736 ? 622 HOH   A O   1 
HETATM 2161 O O   . HOH   E 5 .   ? -3.13518  -2.89318  -22.65483 1.000 40.60180 ? 623 HOH   A O   1 
HETATM 2162 O O   . HOH   E 5 .   ? -3.99756  -1.45589  -8.87276  1.000 43.95452 ? 624 HOH   A O   1 
HETATM 2163 O O   . HOH   E 5 .   ? 6.36856   -7.61918  -32.40211 1.000 46.70186 ? 625 HOH   A O   1 
HETATM 2164 O O   . HOH   E 5 .   ? -5.35619  -0.85797  -11.47138 1.000 45.85694 ? 626 HOH   A O   1 
HETATM 2165 O O   . HOH   E 5 .   ? -6.09817  -20.21117 -5.24127  1.000 44.26882 ? 627 HOH   A O   1 
HETATM 2166 O O   . HOH   E 5 .   ? 9.48171   -9.81596  0.22600   1.000 49.60203 ? 628 HOH   A O   1 
HETATM 2167 O O   . HOH   E 5 .   ? -14.10263 -22.01255 -16.94805 1.000 36.41132 ? 629 HOH   A O   1 
HETATM 2168 O O   . HOH   E 5 .   ? 5.77793   -15.07719 -46.53031 1.000 46.50874 ? 630 HOH   A O   1 
HETATM 2169 O O   . HOH   E 5 .   ? 12.50461  -16.56317 -35.68801 1.000 40.43912 ? 631 HOH   A O   1 
HETATM 2170 O O   . HOH   E 5 .   ? 14.79192  -12.58726 -3.80217  1.000 45.04909 ? 632 HOH   A O   1 
HETATM 2171 O O   . HOH   E 5 .   ? -4.87457  -21.06687 -32.81320 1.000 38.69968 ? 633 HOH   A O   1 
HETATM 2172 O O   . HOH   E 5 .   ? 13.91108  -23.69096 -32.07460 1.000 46.42272 ? 634 HOH   A O   1 
HETATM 2173 O O   . HOH   E 5 .   ? 13.30503  -19.14303 -2.51231  1.000 46.92581 ? 635 HOH   A O   1 
HETATM 2174 O O   . HOH   E 5 .   ? 20.06858  -22.17600 -15.88407 1.000 55.02574 ? 636 HOH   A O   1 
HETATM 2175 O O   . HOH   E 5 .   ? -2.25474  -13.97865 -25.42634 1.000 29.57893 ? 637 HOH   A O   1 
HETATM 2176 O O   . HOH   E 5 .   ? 11.07069  -18.93084 -16.57028 1.000 37.65648 ? 638 HOH   A O   1 
HETATM 2177 O O   . HOH   E 5 .   ? -21.29585 -16.75286 -17.00162 1.000 40.36317 ? 639 HOH   A O   1 
HETATM 2178 O O   . HOH   E 5 .   ? -7.84650  -16.45520 -29.28163 1.000 40.86512 ? 640 HOH   A O   1 
HETATM 2179 O O   . HOH   E 5 .   ? -4.31711  -15.32618 -26.56047 1.000 24.01592 ? 641 HOH   A O   1 
HETATM 2180 O O   . HOH   E 5 .   ? 0.16918   -23.55643 -25.75891 1.000 39.76045 ? 642 HOH   A O   1 
HETATM 2181 O O   . HOH   E 5 .   ? 4.50917   -17.41819 -27.65615 1.000 26.75426 ? 643 HOH   A O   1 
HETATM 2182 O O   . HOH   E 5 .   ? 20.36031  -17.84912 -18.83318 1.000 54.01115 ? 644 HOH   A O   1 
HETATM 2183 O O   . HOH   E 5 .   ? -9.66995  -8.98360  -25.33654 1.000 39.94256 ? 645 HOH   A O   1 
HETATM 2184 O O   . HOH   E 5 .   ? -6.32877  -17.38576 -25.88189 1.000 31.92580 ? 646 HOH   A O   1 
HETATM 2185 O O   . HOH   E 5 .   ? 6.35619   -24.52586 -28.18211 1.000 36.88034 ? 647 HOH   A O   1 
HETATM 2186 O O   . HOH   E 5 .   ? 3.62149   -17.25630 -43.16450 1.000 48.08338 ? 648 HOH   A O   1 
HETATM 2187 O O   . HOH   E 5 .   ? 17.18342  -24.01548 -27.24197 1.000 49.64556 ? 649 HOH   A O   1 
HETATM 2188 O O   . HOH   E 5 .   ? 11.94305  -14.07850 -17.59175 1.000 27.53200 ? 650 HOH   A O   1 
HETATM 2189 O O   . HOH   E 5 .   ? 20.85184  -11.99024 -44.75312 1.000 53.55275 ? 651 HOH   A O   1 
HETATM 2190 O O   . HOH   E 5 .   ? 4.83102   -7.75297  -52.26030 1.000 59.37270 ? 652 HOH   A O   1 
HETATM 2191 O O   . HOH   E 5 .   ? 18.27684  -14.67717 -2.59894  1.000 49.67559 ? 653 HOH   A O   1 
HETATM 2192 O O   . HOH   E 5 .   ? -11.96687 -9.59130  -8.24996  1.000 41.21123 ? 654 HOH   A O   1 
HETATM 2193 O O   . HOH   E 5 .   ? 16.91335  -14.40827 -6.80722  1.000 46.56756 ? 655 HOH   A O   1 
HETATM 2194 O O   . HOH   E 5 .   ? 10.31149  -20.30275 -45.45636 1.000 46.33897 ? 656 HOH   A O   1 
HETATM 2195 O O   . HOH   E 5 .   ? 0.18654   -8.48592  -26.40845 1.000 33.30381 ? 657 HOH   A O   1 
HETATM 2196 O O   . HOH   E 5 .   ? -5.44734  -7.41922  -1.94074  1.000 54.84106 ? 658 HOH   A O   1 
HETATM 2197 O O   . HOH   E 5 .   ? -3.47363  -27.01621 -21.78500 1.000 36.01261 ? 659 HOH   A O   1 
HETATM 2198 O O   . HOH   E 5 .   ? 19.20546  -8.13536  -11.40878 1.000 52.77402 ? 660 HOH   A O   1 
HETATM 2199 O O   . HOH   E 5 .   ? -14.85487 -4.20370  -2.91924  1.000 56.45448 ? 661 HOH   A O   1 
HETATM 2200 O O   . HOH   E 5 .   ? 11.38510  -2.16518  -31.86901 1.000 44.75622 ? 662 HOH   A O   1 
HETATM 2201 O O   . HOH   E 5 .   ? 25.47706  -8.39450  -39.31922 1.000 57.03979 ? 663 HOH   A O   1 
HETATM 2202 O O   . HOH   E 5 .   ? -4.32670  -18.45129 -36.20496 1.000 43.12022 ? 664 HOH   A O   1 
HETATM 2203 O O   . HOH   E 5 .   ? 2.68853   -3.97216  -25.09229 1.000 47.53371 ? 665 HOH   A O   1 
HETATM 2204 O O   . HOH   E 5 .   ? -13.02005 -7.33777  -9.65629  1.000 45.45974 ? 666 HOH   A O   1 
HETATM 2205 O O   . HOH   E 5 .   ? 6.82071   -25.64541 -23.96866 1.000 34.44235 ? 667 HOH   A O   1 
HETATM 2206 O O   . HOH   E 5 .   ? 20.34617  -6.13491  -46.14588 1.000 53.91929 ? 668 HOH   A O   1 
HETATM 2207 O O   . HOH   E 5 .   ? 9.13912   -25.87521 -25.32122 1.000 43.79686 ? 669 HOH   A O   1 
HETATM 2208 O O   . HOH   E 5 .   ? -14.28218 -11.33766 -12.41102 1.000 37.58338 ? 670 HOH   A O   1 
HETATM 2209 O O   . HOH   E 5 .   ? 21.44839  -1.48508  -39.13049 1.000 48.52984 ? 671 HOH   A O   1 
HETATM 2210 O O   . HOH   E 5 .   ? -17.21924 -27.93897 -20.38368 1.000 46.21493 ? 672 HOH   A O   1 
HETATM 2211 O O   . HOH   E 5 .   ? 2.82730   -23.48584 -44.79107 1.000 59.91909 ? 673 HOH   A O   1 
HETATM 2212 O O   . HOH   E 5 .   ? 22.04766  -10.18258 -13.09957 1.000 40.95797 ? 674 HOH   A O   1 
HETATM 2213 O O   . HOH   E 5 .   ? 11.31366  -20.21097 -12.24267 1.000 37.47949 ? 675 HOH   A O   1 
HETATM 2214 O O   . HOH   E 5 .   ? -10.62174 -12.79327 -27.36638 1.000 45.03440 ? 676 HOH   A O   1 
HETATM 2215 O O   . HOH   E 5 .   ? 3.50254   1.56690   -18.92504 1.000 41.44880 ? 677 HOH   A O   1 
HETATM 2216 O O   . HOH   E 5 .   ? 13.43595  -10.20722 -51.71061 1.000 49.41456 ? 678 HOH   A O   1 
HETATM 2217 O O   . HOH   E 5 .   ? 20.90212  -23.73109 -35.42375 1.000 62.79793 ? 679 HOH   A O   1 
HETATM 2218 O O   . HOH   E 5 .   ? -10.01973 -4.87839  -42.41562 1.000 57.34460 ? 680 HOH   A O   1 
HETATM 2219 O O   . HOH   E 5 .   ? -4.34832  -18.13441 -33.57568 1.000 42.46152 ? 681 HOH   A O   1 
HETATM 2220 O O   . HOH   E 5 .   ? 12.00682  -22.35698 -10.59286 1.000 55.30430 ? 682 HOH   A O   1 
HETATM 2221 O O   . HOH   E 5 .   ? 16.81030  1.33705   -22.83046 1.000 46.89412 ? 683 HOH   A O   1 
HETATM 2222 O O   . HOH   E 5 .   ? -10.14502 -9.42934  -15.16434 1.000 35.11989 ? 684 HOH   A O   1 
HETATM 2223 O O   . HOH   E 5 .   ? 8.28658   -17.59380 4.16578   1.000 45.15985 ? 685 HOH   A O   1 
HETATM 2224 O O   . HOH   E 5 .   ? 20.74562  -9.15391  -45.28188 1.000 53.04576 ? 686 HOH   A O   1 
HETATM 2225 O O   . HOH   E 5 .   ? -14.74692 -10.16409 -18.39247 1.000 46.91020 ? 687 HOH   A O   1 
HETATM 2226 O O   . HOH   E 5 .   ? 10.57086  -18.57801 -36.97373 1.000 44.26708 ? 688 HOH   A O   1 
HETATM 2227 O O   . HOH   E 5 .   ? 21.69493  -5.33759  -32.01493 1.000 53.44152 ? 689 HOH   A O   1 
HETATM 2228 O O   . HOH   E 5 .   ? -12.30103 -23.06699 -15.41550 1.000 36.62031 ? 690 HOH   A O   1 
HETATM 2229 O O   . HOH   E 5 .   ? -5.49888  -1.11448  -32.64725 1.000 53.61420 ? 691 HOH   A O   1 
HETATM 2230 O O   . HOH   E 5 .   ? -5.89045  -13.22454 -37.65300 1.000 50.05981 ? 692 HOH   A O   1 
HETATM 2231 O O   . HOH   E 5 .   ? 11.537    6.304     -38.942   1.000 50.86027 ? 693 HOH   A O   1 
HETATM 2232 O O   . HOH   E 5 .   ? -7.72022  -11.20596 -36.19914 1.000 47.77452 ? 694 HOH   A O   1 
HETATM 2233 O O   . HOH   E 5 .   ? -13.22511 -12.60097 -10.41977 1.000 42.65455 ? 695 HOH   A O   1 
HETATM 2234 O O   . HOH   E 5 .   ? 18.87970  -14.10318 -4.89631  1.000 45.25403 ? 696 HOH   A O   1 
HETATM 2235 O O   . HOH   E 5 .   ? 15.21804  -21.19858 -14.73697 1.000 53.08994 ? 697 HOH   A O   1 
HETATM 2236 O O   . HOH   E 5 .   ? 7.151     1.882     -25.301   1.000 52.15807 ? 698 HOH   A O   1 
HETATM 2237 O O   . HOH   E 5 .   ? -9.75118  -10.16737 -27.58654 1.000 47.34102 ? 699 HOH   A O   1 
HETATM 2238 O O   . HOH   E 5 .   ? 8.85491   -25.50356 -27.97979 1.000 48.82902 ? 700 HOH   A O   1 
HETATM 2239 O O   . HOH   E 5 .   ? 23.37402  -5.93037  -45.81657 1.000 56.08571 ? 701 HOH   A O   1 
HETATM 2240 O O   . HOH   E 5 .   ? 5.64161   -27.65933 -8.15883  1.000 61.12382 ? 702 HOH   A O   1 
HETATM 2241 O O   . HOH   E 5 .   ? 9.83359   -1.53458  -33.67454 1.000 49.00066 ? 703 HOH   A O   1 
HETATM 2242 O O   . HOH   E 5 .   ? -5.02065  -27.41210 -23.49625 1.000 48.74608 ? 704 HOH   A O   1 
HETATM 2243 O O   . HOH   E 5 .   ? 18.40573  -8.29459  -46.77163 1.000 51.30439 ? 705 HOH   A O   1 
HETATM 2244 O O   . HOH   E 5 .   ? 12.65177  -20.23418 -14.78085 1.000 41.71420 ? 706 HOH   A O   1 
HETATM 2245 O O   . HOH   E 5 .   ? -10.89187 -9.55995  -30.26060 1.000 55.68317 ? 707 HOH   A O   1 
HETATM 2246 O O   . HOH   E 5 .   ? 4.88734   -25.00714 -25.93430 1.000 41.24119 ? 708 HOH   A O   1 
HETATM 2247 O O   . HOH   E 5 .   ? 3.59843   -26.82919 -9.82042  1.000 57.05627 ? 709 HOH   A O   1 
HETATM 2248 O O   . HOH   F 5 .   ? 9.54722   1.07393   -14.36590 1.000 48.66909 ? 201 HOH   B O   1 
HETATM 2249 O O   . HOH   F 5 .   ? 14.62544  4.93008   -10.56251 1.000 54.68476 ? 202 HOH   B O   1 
HETATM 2250 O O   . HOH   F 5 .   ? 16.99231  0.76316   -15.85558 1.000 46.04684 ? 203 HOH   B O   1 
HETATM 2251 O O   . HOH   F 5 .   ? 6.42803   0.70638   -6.27895  1.000 53.27235 ? 204 HOH   B O   1 
# 
