data_8YT9
# 
_entry.id   8YT9 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YT9         pdb_00008yt9 10.2210/pdb8yt9/pdb 
WWPDB D_1300046341 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YT9 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          8YT6 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yo@phs.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Takuya 
_pdbx_contact_author.name_last          Yoshida 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3491-9344 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachibana, K.' 1  ? 
'Morie, T.'     2  ? 
'Fukuda, S.'    3  ? 
'Yuzuriha, T.'  4  ? 
'Ishimoto, K.'  5  ? 
'Nunomura, K.'  6  ? 
'Lin, B.'       7  ? 
'Miyachi, H.'   8  ? 
'Oki, H.'       9  ? 
'Kawahara, K.'  10 ? 
'Meguro, K.'    11 ? 
'Nakagawa, S.'  12 ? 
'Tsujikawa, K.' 13 ? 
'Akai, S.'      14 ? 
'Doi, T.'       15 ? 
'Yoshida, T.'   16 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachibana, K.' 1  ? 
primary 'Morie, T.'     2  ? 
primary 'Fukuda, S.'    3  ? 
primary 'Yuzuriha, T.'  4  ? 
primary 'Ishimoto, K.'  5  ? 
primary 'Nunomura, K.'  6  ? 
primary 'Lin, B.'       7  ? 
primary 'Miyachi, H.'   8  ? 
primary 'Oki, H.'       9  ? 
primary 'Kawahara, K.'  10 ? 
primary 'Meguro, K.'    11 ? 
primary 'Nakagawa, S.'  12 ? 
primary 'Tsujikawa, K.' 13 ? 
primary 'Akai, S.'      14 ? 
primary 'Doi, T.'       15 ? 
primary 'Yoshida, T.'   16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peroxisome proliferator-activated receptor alpha' 30684.814 1   ? ? ? ? 
2 polymer     syn 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha' 2405.782  1   ? ? ? ? 
3 non-polymer syn 
'1-(4-fluorophenyl)-6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
528.574   1   ? ? ? ? 
4 water       nat water 18.015    193 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'PPAR-alpha,Nuclear receptor subfamily 1 group C member 1'                            
2 'PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
A ? 
2 'polypeptide(L)' no no PQEAEEPSLLKKLLLAPANTQL PQEAEEPSLLKKLLLAPANTQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '1-(4-fluorophenyl)-6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
A1LZY 
4 water                                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   GLN n 
1 4   THR n 
1 5   ALA n 
1 6   ASP n 
1 7   LEU n 
1 8   LYS n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  LYS n 
1 13  ARG n 
1 14  ILE n 
1 15  TYR n 
1 16  GLU n 
1 17  ALA n 
1 18  TYR n 
1 19  LEU n 
1 20  LYS n 
1 21  ASN n 
1 22  PHE n 
1 23  ASN n 
1 24  MET n 
1 25  ASN n 
1 26  LYS n 
1 27  VAL n 
1 28  LYS n 
1 29  ALA n 
1 30  ARG n 
1 31  VAL n 
1 32  ILE n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  LYS n 
1 37  ALA n 
1 38  SER n 
1 39  ASN n 
1 40  ASN n 
1 41  PRO n 
1 42  PRO n 
1 43  PHE n 
1 44  VAL n 
1 45  ILE n 
1 46  HIS n 
1 47  ASP n 
1 48  MET n 
1 49  GLU n 
1 50  THR n 
1 51  LEU n 
1 52  CYS n 
1 53  MET n 
1 54  ALA n 
1 55  GLU n 
1 56  LYS n 
1 57  THR n 
1 58  LEU n 
1 59  VAL n 
1 60  ALA n 
1 61  LYS n 
1 62  LEU n 
1 63  VAL n 
1 64  ALA n 
1 65  ASN n 
1 66  GLY n 
1 67  ILE n 
1 68  GLN n 
1 69  ASN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLU n 
1 74  VAL n 
1 75  ARG n 
1 76  ILE n 
1 77  PHE n 
1 78  HIS n 
1 79  CYS n 
1 80  CYS n 
1 81  GLN n 
1 82  CYS n 
1 83  THR n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  THR n 
1 88  VAL n 
1 89  THR n 
1 90  GLU n 
1 91  LEU n 
1 92  THR n 
1 93  GLU n 
1 94  PHE n 
1 95  ALA n 
1 96  LYS n 
1 97  ALA n 
1 98  ILE n 
1 99  PRO n 
1 100 GLY n 
1 101 PHE n 
1 102 ALA n 
1 103 ASN n 
1 104 LEU n 
1 105 ASP n 
1 106 LEU n 
1 107 ASN n 
1 108 ASP n 
1 109 GLN n 
1 110 VAL n 
1 111 THR n 
1 112 LEU n 
1 113 LEU n 
1 114 LYS n 
1 115 TYR n 
1 116 GLY n 
1 117 VAL n 
1 118 TYR n 
1 119 GLU n 
1 120 ALA n 
1 121 ILE n 
1 122 PHE n 
1 123 ALA n 
1 124 MET n 
1 125 LEU n 
1 126 SER n 
1 127 SER n 
1 128 VAL n 
1 129 MET n 
1 130 ASN n 
1 131 LYS n 
1 132 ASP n 
1 133 GLY n 
1 134 MET n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 TYR n 
1 139 GLY n 
1 140 ASN n 
1 141 GLY n 
1 142 PHE n 
1 143 ILE n 
1 144 THR n 
1 145 ARG n 
1 146 GLU n 
1 147 PHE n 
1 148 LEU n 
1 149 LYS n 
1 150 SER n 
1 151 LEU n 
1 152 ARG n 
1 153 LYS n 
1 154 PRO n 
1 155 PHE n 
1 156 CYS n 
1 157 ASP n 
1 158 ILE n 
1 159 MET n 
1 160 GLU n 
1 161 PRO n 
1 162 LYS n 
1 163 PHE n 
1 164 ASP n 
1 165 PHE n 
1 166 ALA n 
1 167 MET n 
1 168 LYS n 
1 169 PHE n 
1 170 ASN n 
1 171 ALA n 
1 172 LEU n 
1 173 GLU n 
1 174 LEU n 
1 175 ASP n 
1 176 ASP n 
1 177 SER n 
1 178 ASP n 
1 179 ILE n 
1 180 SER n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 ALA n 
1 185 ALA n 
1 186 ILE n 
1 187 ILE n 
1 188 CYS n 
1 189 CYS n 
1 190 GLY n 
1 191 ASP n 
1 192 ARG n 
1 193 PRO n 
1 194 GLY n 
1 195 LEU n 
1 196 LEU n 
1 197 ASN n 
1 198 VAL n 
1 199 GLY n 
1 200 HIS n 
1 201 ILE n 
1 202 GLU n 
1 203 LYS n 
1 204 MET n 
1 205 GLN n 
1 206 GLU n 
1 207 GLY n 
1 208 ILE n 
1 209 VAL n 
1 210 HIS n 
1 211 VAL n 
1 212 LEU n 
1 213 ARG n 
1 214 LEU n 
1 215 HIS n 
1 216 LEU n 
1 217 GLN n 
1 218 SER n 
1 219 ASN n 
1 220 HIS n 
1 221 PRO n 
1 222 ASP n 
1 223 ASP n 
1 224 ILE n 
1 225 PHE n 
1 226 LEU n 
1 227 PHE n 
1 228 PRO n 
1 229 LYS n 
1 230 LEU n 
1 231 LEU n 
1 232 GLN n 
1 233 LYS n 
1 234 MET n 
1 235 ALA n 
1 236 ASP n 
1 237 LEU n 
1 238 ARG n 
1 239 GLN n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 GLU n 
1 244 HIS n 
1 245 ALA n 
1 246 GLN n 
1 247 LEU n 
1 248 VAL n 
1 249 GLN n 
1 250 ILE n 
1 251 ILE n 
1 252 LYS n 
1 253 LYS n 
1 254 THR n 
1 255 GLU n 
1 256 SER n 
1 257 ASP n 
1 258 ALA n 
1 259 ALA n 
1 260 LEU n 
1 261 HIS n 
1 262 PRO n 
1 263 LEU n 
1 264 LEU n 
1 265 GLN n 
1 266 GLU n 
1 267 ILE n 
1 268 TYR n 
1 269 ARG n 
1 270 ASP n 
1 271 MET n 
1 272 TYR n 
2 1   PRO n 
2 2   GLN n 
2 3   GLU n 
2 4   ALA n 
2 5   GLU n 
2 6   GLU n 
2 7   PRO n 
2 8   SER n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  LYS n 
2 13  LEU n 
2 14  LEU n 
2 15  LEU n 
2 16  ALA n 
2 17  PRO n 
2 18  ALA n 
2 19  ASN n 
2 20  THR n 
2 21  GLN n 
2 22  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   272 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PPARA, NR1C1, PPAR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       22 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LZY non-polymer         . 
'1-(4-fluorophenyl)-6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' ? 
'C30 H29 F N4 O4' 528.574 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   197 ?   ?   ?   A . n 
A 1 2   GLY 2   198 ?   ?   ?   A . n 
A 1 3   GLN 3   199 ?   ?   ?   A . n 
A 1 4   THR 4   200 ?   ?   ?   A . n 
A 1 5   ALA 5   201 ?   ?   ?   A . n 
A 1 6   ASP 6   202 202 ASP ASP A . n 
A 1 7   LEU 7   203 203 LEU LEU A . n 
A 1 8   LYS 8   204 204 LYS LYS A . n 
A 1 9   SER 9   205 205 SER SER A . n 
A 1 10  LEU 10  206 206 LEU LEU A . n 
A 1 11  ALA 11  207 207 ALA ALA A . n 
A 1 12  LYS 12  208 208 LYS LYS A . n 
A 1 13  ARG 13  209 209 ARG ARG A . n 
A 1 14  ILE 14  210 210 ILE ILE A . n 
A 1 15  TYR 15  211 211 TYR TYR A . n 
A 1 16  GLU 16  212 212 GLU GLU A . n 
A 1 17  ALA 17  213 213 ALA ALA A . n 
A 1 18  TYR 18  214 214 TYR TYR A . n 
A 1 19  LEU 19  215 215 LEU LEU A . n 
A 1 20  LYS 20  216 216 LYS LYS A . n 
A 1 21  ASN 21  217 217 ASN ASN A . n 
A 1 22  PHE 22  218 218 PHE PHE A . n 
A 1 23  ASN 23  219 219 ASN ASN A . n 
A 1 24  MET 24  220 220 MET MET A . n 
A 1 25  ASN 25  221 221 ASN ASN A . n 
A 1 26  LYS 26  222 222 LYS LYS A . n 
A 1 27  VAL 27  223 223 VAL VAL A . n 
A 1 28  LYS 28  224 224 LYS LYS A . n 
A 1 29  ALA 29  225 225 ALA ALA A . n 
A 1 30  ARG 30  226 226 ARG ARG A . n 
A 1 31  VAL 31  227 227 VAL VAL A . n 
A 1 32  ILE 32  228 228 ILE ILE A . n 
A 1 33  LEU 33  229 229 LEU LEU A . n 
A 1 34  SER 34  230 230 SER SER A . n 
A 1 35  GLY 35  231 231 GLY GLY A . n 
A 1 36  LYS 36  232 ?   ?   ?   A . n 
A 1 37  ALA 37  233 ?   ?   ?   A . n 
A 1 38  SER 38  234 ?   ?   ?   A . n 
A 1 39  ASN 39  235 ?   ?   ?   A . n 
A 1 40  ASN 40  236 ?   ?   ?   A . n 
A 1 41  PRO 41  237 237 PRO PRO A . n 
A 1 42  PRO 42  238 238 PRO PRO A . n 
A 1 43  PHE 43  239 239 PHE PHE A . n 
A 1 44  VAL 44  240 240 VAL VAL A . n 
A 1 45  ILE 45  241 241 ILE ILE A . n 
A 1 46  HIS 46  242 242 HIS HIS A . n 
A 1 47  ASP 47  243 243 ASP ASP A . n 
A 1 48  MET 48  244 244 MET MET A . n 
A 1 49  GLU 49  245 245 GLU GLU A . n 
A 1 50  THR 50  246 246 THR THR A . n 
A 1 51  LEU 51  247 247 LEU LEU A . n 
A 1 52  CYS 52  248 248 CYS CYS A . n 
A 1 53  MET 53  249 249 MET MET A . n 
A 1 54  ALA 54  250 250 ALA ALA A . n 
A 1 55  GLU 55  251 251 GLU GLU A . n 
A 1 56  LYS 56  252 252 LYS LYS A . n 
A 1 57  THR 57  253 253 THR THR A . n 
A 1 58  LEU 58  254 254 LEU LEU A . n 
A 1 59  VAL 59  255 255 VAL VAL A . n 
A 1 60  ALA 60  256 256 ALA ALA A . n 
A 1 61  LYS 61  257 257 LYS LYS A . n 
A 1 62  LEU 62  258 ?   ?   ?   A . n 
A 1 63  VAL 63  259 ?   ?   ?   A . n 
A 1 64  ALA 64  260 ?   ?   ?   A . n 
A 1 65  ASN 65  261 ?   ?   ?   A . n 
A 1 66  GLY 66  262 ?   ?   ?   A . n 
A 1 67  ILE 67  263 ?   ?   ?   A . n 
A 1 68  GLN 68  264 ?   ?   ?   A . n 
A 1 69  ASN 69  265 ?   ?   ?   A . n 
A 1 70  LYS 70  266 266 LYS LYS A . n 
A 1 71  GLU 71  267 267 GLU GLU A . n 
A 1 72  ALA 72  268 268 ALA ALA A . n 
A 1 73  GLU 73  269 269 GLU GLU A . n 
A 1 74  VAL 74  270 270 VAL VAL A . n 
A 1 75  ARG 75  271 271 ARG ARG A . n 
A 1 76  ILE 76  272 272 ILE ILE A . n 
A 1 77  PHE 77  273 273 PHE PHE A . n 
A 1 78  HIS 78  274 274 HIS HIS A . n 
A 1 79  CYS 79  275 275 CYS CYS A . n 
A 1 80  CYS 80  276 276 CYS CYS A . n 
A 1 81  GLN 81  277 277 GLN GLN A . n 
A 1 82  CYS 82  278 278 CYS CYS A . n 
A 1 83  THR 83  279 279 THR THR A . n 
A 1 84  SER 84  280 280 SER SER A . n 
A 1 85  VAL 85  281 281 VAL VAL A . n 
A 1 86  GLU 86  282 282 GLU GLU A . n 
A 1 87  THR 87  283 283 THR THR A . n 
A 1 88  VAL 88  284 284 VAL VAL A . n 
A 1 89  THR 89  285 285 THR THR A . n 
A 1 90  GLU 90  286 286 GLU GLU A . n 
A 1 91  LEU 91  287 287 LEU LEU A . n 
A 1 92  THR 92  288 288 THR THR A . n 
A 1 93  GLU 93  289 289 GLU GLU A . n 
A 1 94  PHE 94  290 290 PHE PHE A . n 
A 1 95  ALA 95  291 291 ALA ALA A . n 
A 1 96  LYS 96  292 292 LYS LYS A . n 
A 1 97  ALA 97  293 293 ALA ALA A . n 
A 1 98  ILE 98  294 294 ILE ILE A . n 
A 1 99  PRO 99  295 295 PRO PRO A . n 
A 1 100 GLY 100 296 296 GLY GLY A . n 
A 1 101 PHE 101 297 297 PHE PHE A . n 
A 1 102 ALA 102 298 298 ALA ALA A . n 
A 1 103 ASN 103 299 299 ASN ASN A . n 
A 1 104 LEU 104 300 300 LEU LEU A . n 
A 1 105 ASP 105 301 301 ASP ASP A . n 
A 1 106 LEU 106 302 302 LEU LEU A . n 
A 1 107 ASN 107 303 303 ASN ASN A . n 
A 1 108 ASP 108 304 304 ASP ASP A . n 
A 1 109 GLN 109 305 305 GLN GLN A . n 
A 1 110 VAL 110 306 306 VAL VAL A . n 
A 1 111 THR 111 307 307 THR THR A . n 
A 1 112 LEU 112 308 308 LEU LEU A . n 
A 1 113 LEU 113 309 309 LEU LEU A . n 
A 1 114 LYS 114 310 310 LYS LYS A . n 
A 1 115 TYR 115 311 311 TYR TYR A . n 
A 1 116 GLY 116 312 312 GLY GLY A . n 
A 1 117 VAL 117 313 313 VAL VAL A . n 
A 1 118 TYR 118 314 314 TYR TYR A . n 
A 1 119 GLU 119 315 315 GLU GLU A . n 
A 1 120 ALA 120 316 316 ALA ALA A . n 
A 1 121 ILE 121 317 317 ILE ILE A . n 
A 1 122 PHE 122 318 318 PHE PHE A . n 
A 1 123 ALA 123 319 319 ALA ALA A . n 
A 1 124 MET 124 320 320 MET MET A . n 
A 1 125 LEU 125 321 321 LEU LEU A . n 
A 1 126 SER 126 322 322 SER SER A . n 
A 1 127 SER 127 323 323 SER SER A . n 
A 1 128 VAL 128 324 324 VAL VAL A . n 
A 1 129 MET 129 325 325 MET MET A . n 
A 1 130 ASN 130 326 326 ASN ASN A . n 
A 1 131 LYS 131 327 327 LYS LYS A . n 
A 1 132 ASP 132 328 328 ASP ASP A . n 
A 1 133 GLY 133 329 329 GLY GLY A . n 
A 1 134 MET 134 330 330 MET MET A . n 
A 1 135 LEU 135 331 331 LEU LEU A . n 
A 1 136 VAL 136 332 332 VAL VAL A . n 
A 1 137 ALA 137 333 333 ALA ALA A . n 
A 1 138 TYR 138 334 334 TYR TYR A . n 
A 1 139 GLY 139 335 335 GLY GLY A . n 
A 1 140 ASN 140 336 336 ASN ASN A . n 
A 1 141 GLY 141 337 337 GLY GLY A . n 
A 1 142 PHE 142 338 338 PHE PHE A . n 
A 1 143 ILE 143 339 339 ILE ILE A . n 
A 1 144 THR 144 340 340 THR THR A . n 
A 1 145 ARG 145 341 341 ARG ARG A . n 
A 1 146 GLU 146 342 342 GLU GLU A . n 
A 1 147 PHE 147 343 343 PHE PHE A . n 
A 1 148 LEU 148 344 344 LEU LEU A . n 
A 1 149 LYS 149 345 345 LYS LYS A . n 
A 1 150 SER 150 346 346 SER SER A . n 
A 1 151 LEU 151 347 347 LEU LEU A . n 
A 1 152 ARG 152 348 348 ARG ARG A . n 
A 1 153 LYS 153 349 349 LYS LYS A . n 
A 1 154 PRO 154 350 350 PRO PRO A . n 
A 1 155 PHE 155 351 351 PHE PHE A . n 
A 1 156 CYS 156 352 352 CYS CYS A . n 
A 1 157 ASP 157 353 353 ASP ASP A . n 
A 1 158 ILE 158 354 354 ILE ILE A . n 
A 1 159 MET 159 355 355 MET MET A . n 
A 1 160 GLU 160 356 356 GLU GLU A . n 
A 1 161 PRO 161 357 357 PRO PRO A . n 
A 1 162 LYS 162 358 358 LYS LYS A . n 
A 1 163 PHE 163 359 359 PHE PHE A . n 
A 1 164 ASP 164 360 360 ASP ASP A . n 
A 1 165 PHE 165 361 361 PHE PHE A . n 
A 1 166 ALA 166 362 362 ALA ALA A . n 
A 1 167 MET 167 363 363 MET MET A . n 
A 1 168 LYS 168 364 364 LYS LYS A . n 
A 1 169 PHE 169 365 365 PHE PHE A . n 
A 1 170 ASN 170 366 366 ASN ASN A . n 
A 1 171 ALA 171 367 367 ALA ALA A . n 
A 1 172 LEU 172 368 368 LEU LEU A . n 
A 1 173 GLU 173 369 369 GLU GLU A . n 
A 1 174 LEU 174 370 370 LEU LEU A . n 
A 1 175 ASP 175 371 371 ASP ASP A . n 
A 1 176 ASP 176 372 372 ASP ASP A . n 
A 1 177 SER 177 373 373 SER SER A . n 
A 1 178 ASP 178 374 374 ASP ASP A . n 
A 1 179 ILE 179 375 375 ILE ILE A . n 
A 1 180 SER 180 376 376 SER SER A . n 
A 1 181 LEU 181 377 377 LEU LEU A . n 
A 1 182 PHE 182 378 378 PHE PHE A . n 
A 1 183 VAL 183 379 379 VAL VAL A . n 
A 1 184 ALA 184 380 380 ALA ALA A . n 
A 1 185 ALA 185 381 381 ALA ALA A . n 
A 1 186 ILE 186 382 382 ILE ILE A . n 
A 1 187 ILE 187 383 383 ILE ILE A . n 
A 1 188 CYS 188 384 384 CYS CYS A . n 
A 1 189 CYS 189 385 385 CYS CYS A . n 
A 1 190 GLY 190 386 386 GLY GLY A . n 
A 1 191 ASP 191 387 387 ASP ASP A . n 
A 1 192 ARG 192 388 388 ARG ARG A . n 
A 1 193 PRO 193 389 389 PRO PRO A . n 
A 1 194 GLY 194 390 390 GLY GLY A . n 
A 1 195 LEU 195 391 391 LEU LEU A . n 
A 1 196 LEU 196 392 392 LEU LEU A . n 
A 1 197 ASN 197 393 393 ASN ASN A . n 
A 1 198 VAL 198 394 394 VAL VAL A . n 
A 1 199 GLY 199 395 395 GLY GLY A . n 
A 1 200 HIS 200 396 396 HIS HIS A . n 
A 1 201 ILE 201 397 397 ILE ILE A . n 
A 1 202 GLU 202 398 398 GLU GLU A . n 
A 1 203 LYS 203 399 399 LYS LYS A . n 
A 1 204 MET 204 400 400 MET MET A . n 
A 1 205 GLN 205 401 401 GLN GLN A . n 
A 1 206 GLU 206 402 402 GLU GLU A . n 
A 1 207 GLY 207 403 403 GLY GLY A . n 
A 1 208 ILE 208 404 404 ILE ILE A . n 
A 1 209 VAL 209 405 405 VAL VAL A . n 
A 1 210 HIS 210 406 406 HIS HIS A . n 
A 1 211 VAL 211 407 407 VAL VAL A . n 
A 1 212 LEU 212 408 408 LEU LEU A . n 
A 1 213 ARG 213 409 409 ARG ARG A . n 
A 1 214 LEU 214 410 410 LEU LEU A . n 
A 1 215 HIS 215 411 411 HIS HIS A . n 
A 1 216 LEU 216 412 412 LEU LEU A . n 
A 1 217 GLN 217 413 413 GLN GLN A . n 
A 1 218 SER 218 414 414 SER SER A . n 
A 1 219 ASN 219 415 415 ASN ASN A . n 
A 1 220 HIS 220 416 416 HIS HIS A . n 
A 1 221 PRO 221 417 417 PRO PRO A . n 
A 1 222 ASP 222 418 418 ASP ASP A . n 
A 1 223 ASP 223 419 419 ASP ASP A . n 
A 1 224 ILE 224 420 420 ILE ILE A . n 
A 1 225 PHE 225 421 421 PHE PHE A . n 
A 1 226 LEU 226 422 422 LEU LEU A . n 
A 1 227 PHE 227 423 423 PHE PHE A . n 
A 1 228 PRO 228 424 424 PRO PRO A . n 
A 1 229 LYS 229 425 425 LYS LYS A . n 
A 1 230 LEU 230 426 426 LEU LEU A . n 
A 1 231 LEU 231 427 427 LEU LEU A . n 
A 1 232 GLN 232 428 428 GLN GLN A . n 
A 1 233 LYS 233 429 429 LYS LYS A . n 
A 1 234 MET 234 430 430 MET MET A . n 
A 1 235 ALA 235 431 431 ALA ALA A . n 
A 1 236 ASP 236 432 432 ASP ASP A . n 
A 1 237 LEU 237 433 433 LEU LEU A . n 
A 1 238 ARG 238 434 434 ARG ARG A . n 
A 1 239 GLN 239 435 435 GLN GLN A . n 
A 1 240 LEU 240 436 436 LEU LEU A . n 
A 1 241 VAL 241 437 437 VAL VAL A . n 
A 1 242 THR 242 438 438 THR THR A . n 
A 1 243 GLU 243 439 439 GLU GLU A . n 
A 1 244 HIS 244 440 440 HIS HIS A . n 
A 1 245 ALA 245 441 441 ALA ALA A . n 
A 1 246 GLN 246 442 442 GLN GLN A . n 
A 1 247 LEU 247 443 443 LEU LEU A . n 
A 1 248 VAL 248 444 444 VAL VAL A . n 
A 1 249 GLN 249 445 445 GLN GLN A . n 
A 1 250 ILE 250 446 446 ILE ILE A . n 
A 1 251 ILE 251 447 447 ILE ILE A . n 
A 1 252 LYS 252 448 448 LYS LYS A . n 
A 1 253 LYS 253 449 449 LYS LYS A . n 
A 1 254 THR 254 450 450 THR THR A . n 
A 1 255 GLU 255 451 451 GLU GLU A . n 
A 1 256 SER 256 452 452 SER SER A . n 
A 1 257 ASP 257 453 453 ASP ASP A . n 
A 1 258 ALA 258 454 454 ALA ALA A . n 
A 1 259 ALA 259 455 455 ALA ALA A . n 
A 1 260 LEU 260 456 456 LEU LEU A . n 
A 1 261 HIS 261 457 457 HIS HIS A . n 
A 1 262 PRO 262 458 458 PRO PRO A . n 
A 1 263 LEU 263 459 459 LEU LEU A . n 
A 1 264 LEU 264 460 460 LEU LEU A . n 
A 1 265 GLN 265 461 461 GLN GLN A . n 
A 1 266 GLU 266 462 462 GLU GLU A . n 
A 1 267 ILE 267 463 463 ILE ILE A . n 
A 1 268 TYR 268 464 464 TYR TYR A . n 
A 1 269 ARG 269 465 465 ARG ARG A . n 
A 1 270 ASP 270 466 466 ASP ASP A . n 
A 1 271 MET 271 467 467 MET MET A . n 
A 1 272 TYR 272 468 468 TYR TYR A . n 
B 2 1   PRO 1   135 ?   ?   ?   B . n 
B 2 2   GLN 2   136 ?   ?   ?   B . n 
B 2 3   GLU 3   137 ?   ?   ?   B . n 
B 2 4   ALA 4   138 ?   ?   ?   B . n 
B 2 5   GLU 5   139 ?   ?   ?   B . n 
B 2 6   GLU 6   140 ?   ?   ?   B . n 
B 2 7   PRO 7   141 141 PRO PRO B . n 
B 2 8   SER 8   142 142 SER SER B . n 
B 2 9   LEU 9   143 143 LEU LEU B . n 
B 2 10  LEU 10  144 144 LEU LEU B . n 
B 2 11  LYS 11  145 145 LYS LYS B . n 
B 2 12  LYS 12  146 146 LYS LYS B . n 
B 2 13  LEU 13  147 147 LEU LEU B . n 
B 2 14  LEU 14  148 148 LEU LEU B . n 
B 2 15  LEU 15  149 149 LEU LEU B . n 
B 2 16  ALA 16  150 150 ALA ALA B . n 
B 2 17  PRO 17  151 ?   ?   ?   B . n 
B 2 18  ALA 18  152 ?   ?   ?   B . n 
B 2 19  ASN 19  153 ?   ?   ?   B . n 
B 2 20  THR 20  154 ?   ?   ?   B . n 
B 2 21  GLN 21  155 ?   ?   ?   B . n 
B 2 22  LEU 22  156 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1LZY 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1LZY 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1LZY 1   500 500 A1LZY A03 A . 
D 4 HOH   1   601 139 HOH   HOH A . 
D 4 HOH   2   602 149 HOH   HOH A . 
D 4 HOH   3   603 137 HOH   HOH A . 
D 4 HOH   4   604 167 HOH   HOH A . 
D 4 HOH   5   605 77  HOH   HOH A . 
D 4 HOH   6   606 177 HOH   HOH A . 
D 4 HOH   7   607 141 HOH   HOH A . 
D 4 HOH   8   608 132 HOH   HOH A . 
D 4 HOH   9   609 67  HOH   HOH A . 
D 4 HOH   10  610 164 HOH   HOH A . 
D 4 HOH   11  611 80  HOH   HOH A . 
D 4 HOH   12  612 191 HOH   HOH A . 
D 4 HOH   13  613 84  HOH   HOH A . 
D 4 HOH   14  614 28  HOH   HOH A . 
D 4 HOH   15  615 57  HOH   HOH A . 
D 4 HOH   16  616 99  HOH   HOH A . 
D 4 HOH   17  617 21  HOH   HOH A . 
D 4 HOH   18  618 38  HOH   HOH A . 
D 4 HOH   19  619 174 HOH   HOH A . 
D 4 HOH   20  620 113 HOH   HOH A . 
D 4 HOH   21  621 115 HOH   HOH A . 
D 4 HOH   22  622 12  HOH   HOH A . 
D 4 HOH   23  623 46  HOH   HOH A . 
D 4 HOH   24  624 76  HOH   HOH A . 
D 4 HOH   25  625 161 HOH   HOH A . 
D 4 HOH   26  626 35  HOH   HOH A . 
D 4 HOH   27  627 9   HOH   HOH A . 
D 4 HOH   28  628 2   HOH   HOH A . 
D 4 HOH   29  629 27  HOH   HOH A . 
D 4 HOH   30  630 96  HOH   HOH A . 
D 4 HOH   31  631 104 HOH   HOH A . 
D 4 HOH   32  632 58  HOH   HOH A . 
D 4 HOH   33  633 3   HOH   HOH A . 
D 4 HOH   34  634 107 HOH   HOH A . 
D 4 HOH   35  635 130 HOH   HOH A . 
D 4 HOH   36  636 108 HOH   HOH A . 
D 4 HOH   37  637 122 HOH   HOH A . 
D 4 HOH   38  638 101 HOH   HOH A . 
D 4 HOH   39  639 79  HOH   HOH A . 
D 4 HOH   40  640 8   HOH   HOH A . 
D 4 HOH   41  641 24  HOH   HOH A . 
D 4 HOH   42  642 42  HOH   HOH A . 
D 4 HOH   43  643 10  HOH   HOH A . 
D 4 HOH   44  644 26  HOH   HOH A . 
D 4 HOH   45  645 7   HOH   HOH A . 
D 4 HOH   46  646 65  HOH   HOH A . 
D 4 HOH   47  647 32  HOH   HOH A . 
D 4 HOH   48  648 33  HOH   HOH A . 
D 4 HOH   49  649 148 HOH   HOH A . 
D 4 HOH   50  650 92  HOH   HOH A . 
D 4 HOH   51  651 52  HOH   HOH A . 
D 4 HOH   52  652 54  HOH   HOH A . 
D 4 HOH   53  653 6   HOH   HOH A . 
D 4 HOH   54  654 37  HOH   HOH A . 
D 4 HOH   55  655 41  HOH   HOH A . 
D 4 HOH   56  656 39  HOH   HOH A . 
D 4 HOH   57  657 102 HOH   HOH A . 
D 4 HOH   58  658 25  HOH   HOH A . 
D 4 HOH   59  659 155 HOH   HOH A . 
D 4 HOH   60  660 162 HOH   HOH A . 
D 4 HOH   61  661 81  HOH   HOH A . 
D 4 HOH   62  662 95  HOH   HOH A . 
D 4 HOH   63  663 45  HOH   HOH A . 
D 4 HOH   64  664 13  HOH   HOH A . 
D 4 HOH   65  665 120 HOH   HOH A . 
D 4 HOH   66  666 182 HOH   HOH A . 
D 4 HOH   67  667 90  HOH   HOH A . 
D 4 HOH   68  668 140 HOH   HOH A . 
D 4 HOH   69  669 189 HOH   HOH A . 
D 4 HOH   70  670 114 HOH   HOH A . 
D 4 HOH   71  671 98  HOH   HOH A . 
D 4 HOH   72  672 18  HOH   HOH A . 
D 4 HOH   73  673 40  HOH   HOH A . 
D 4 HOH   74  674 51  HOH   HOH A . 
D 4 HOH   75  675 71  HOH   HOH A . 
D 4 HOH   76  676 49  HOH   HOH A . 
D 4 HOH   77  677 183 HOH   HOH A . 
D 4 HOH   78  678 170 HOH   HOH A . 
D 4 HOH   79  679 85  HOH   HOH A . 
D 4 HOH   80  680 31  HOH   HOH A . 
D 4 HOH   81  681 62  HOH   HOH A . 
D 4 HOH   82  682 1   HOH   HOH A . 
D 4 HOH   83  683 4   HOH   HOH A . 
D 4 HOH   84  684 53  HOH   HOH A . 
D 4 HOH   85  685 11  HOH   HOH A . 
D 4 HOH   86  686 50  HOH   HOH A . 
D 4 HOH   87  687 23  HOH   HOH A . 
D 4 HOH   88  688 83  HOH   HOH A . 
D 4 HOH   89  689 175 HOH   HOH A . 
D 4 HOH   90  690 22  HOH   HOH A . 
D 4 HOH   91  691 66  HOH   HOH A . 
D 4 HOH   92  692 75  HOH   HOH A . 
D 4 HOH   93  693 15  HOH   HOH A . 
D 4 HOH   94  694 142 HOH   HOH A . 
D 4 HOH   95  695 125 HOH   HOH A . 
D 4 HOH   96  696 112 HOH   HOH A . 
D 4 HOH   97  697 59  HOH   HOH A . 
D 4 HOH   98  698 144 HOH   HOH A . 
D 4 HOH   99  699 16  HOH   HOH A . 
D 4 HOH   100 700 94  HOH   HOH A . 
D 4 HOH   101 701 5   HOH   HOH A . 
D 4 HOH   102 702 19  HOH   HOH A . 
D 4 HOH   103 703 29  HOH   HOH A . 
D 4 HOH   104 704 47  HOH   HOH A . 
D 4 HOH   105 705 61  HOH   HOH A . 
D 4 HOH   106 706 168 HOH   HOH A . 
D 4 HOH   107 707 117 HOH   HOH A . 
D 4 HOH   108 708 159 HOH   HOH A . 
D 4 HOH   109 709 91  HOH   HOH A . 
D 4 HOH   110 710 153 HOH   HOH A . 
D 4 HOH   111 711 64  HOH   HOH A . 
D 4 HOH   112 712 124 HOH   HOH A . 
D 4 HOH   113 713 169 HOH   HOH A . 
D 4 HOH   114 714 133 HOH   HOH A . 
D 4 HOH   115 715 121 HOH   HOH A . 
D 4 HOH   116 716 36  HOH   HOH A . 
D 4 HOH   117 717 128 HOH   HOH A . 
D 4 HOH   118 718 55  HOH   HOH A . 
D 4 HOH   119 719 14  HOH   HOH A . 
D 4 HOH   120 720 187 HOH   HOH A . 
D 4 HOH   121 721 87  HOH   HOH A . 
D 4 HOH   122 722 160 HOH   HOH A . 
D 4 HOH   123 723 171 HOH   HOH A . 
D 4 HOH   124 724 17  HOH   HOH A . 
D 4 HOH   125 725 78  HOH   HOH A . 
D 4 HOH   126 726 34  HOH   HOH A . 
D 4 HOH   127 727 116 HOH   HOH A . 
D 4 HOH   128 728 103 HOH   HOH A . 
D 4 HOH   129 729 190 HOH   HOH A . 
D 4 HOH   130 730 82  HOH   HOH A . 
D 4 HOH   131 731 100 HOH   HOH A . 
D 4 HOH   132 732 126 HOH   HOH A . 
D 4 HOH   133 733 86  HOH   HOH A . 
D 4 HOH   134 734 185 HOH   HOH A . 
D 4 HOH   135 735 181 HOH   HOH A . 
D 4 HOH   136 736 72  HOH   HOH A . 
D 4 HOH   137 737 180 HOH   HOH A . 
D 4 HOH   138 738 20  HOH   HOH A . 
D 4 HOH   139 739 105 HOH   HOH A . 
D 4 HOH   140 740 193 HOH   HOH A . 
D 4 HOH   141 741 143 HOH   HOH A . 
D 4 HOH   142 742 106 HOH   HOH A . 
D 4 HOH   143 743 30  HOH   HOH A . 
D 4 HOH   144 744 188 HOH   HOH A . 
D 4 HOH   145 745 118 HOH   HOH A . 
D 4 HOH   146 746 186 HOH   HOH A . 
D 4 HOH   147 747 129 HOH   HOH A . 
D 4 HOH   148 748 145 HOH   HOH A . 
D 4 HOH   149 749 68  HOH   HOH A . 
D 4 HOH   150 750 151 HOH   HOH A . 
D 4 HOH   151 751 60  HOH   HOH A . 
D 4 HOH   152 752 43  HOH   HOH A . 
D 4 HOH   153 753 134 HOH   HOH A . 
D 4 HOH   154 754 138 HOH   HOH A . 
D 4 HOH   155 755 135 HOH   HOH A . 
D 4 HOH   156 756 179 HOH   HOH A . 
D 4 HOH   157 757 147 HOH   HOH A . 
D 4 HOH   158 758 136 HOH   HOH A . 
D 4 HOH   159 759 150 HOH   HOH A . 
D 4 HOH   160 760 172 HOH   HOH A . 
D 4 HOH   161 761 110 HOH   HOH A . 
D 4 HOH   162 762 156 HOH   HOH A . 
D 4 HOH   163 763 163 HOH   HOH A . 
D 4 HOH   164 764 97  HOH   HOH A . 
D 4 HOH   165 765 146 HOH   HOH A . 
D 4 HOH   166 766 56  HOH   HOH A . 
D 4 HOH   167 767 178 HOH   HOH A . 
D 4 HOH   168 768 127 HOH   HOH A . 
D 4 HOH   169 769 48  HOH   HOH A . 
D 4 HOH   170 770 192 HOH   HOH A . 
D 4 HOH   171 771 165 HOH   HOH A . 
D 4 HOH   172 772 63  HOH   HOH A . 
D 4 HOH   173 773 166 HOH   HOH A . 
D 4 HOH   174 774 74  HOH   HOH A . 
D 4 HOH   175 775 184 HOH   HOH A . 
D 4 HOH   176 776 158 HOH   HOH A . 
D 4 HOH   177 777 69  HOH   HOH A . 
D 4 HOH   178 778 89  HOH   HOH A . 
D 4 HOH   179 779 173 HOH   HOH A . 
D 4 HOH   180 780 44  HOH   HOH A . 
D 4 HOH   181 781 88  HOH   HOH A . 
D 4 HOH   182 782 73  HOH   HOH A . 
D 4 HOH   183 783 131 HOH   HOH A . 
D 4 HOH   184 784 111 HOH   HOH A . 
D 4 HOH   185 785 109 HOH   HOH A . 
D 4 HOH   186 786 70  HOH   HOH A . 
D 4 HOH   187 787 123 HOH   HOH A . 
D 4 HOH   188 788 157 HOH   HOH A . 
D 4 HOH   189 789 154 HOH   HOH A . 
D 4 HOH   190 790 119 HOH   HOH A . 
E 4 HOH   1   201 176 HOH   HOH B . 
E 4 HOH   2   202 93  HOH   HOH B . 
E 4 HOH   3   203 152 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   106.190 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YT9 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     44.998 
_cell.length_a_esd                 ? 
_cell.length_b                     62.455 
_cell.length_b_esd                 ? 
_cell.length_c                     53.473 
_cell.length_c_esd                 ? 
_cell.volume                       144318.186 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YT9 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YT9 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.18 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.59 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES-NaOH, 19-23% PEG 4000, 19-23% 1,2-propanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-12-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL26B1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL26B1 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          25.86 
_reflns.entry_id                                       8YT9 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.59 
_reflns.d_resolution_low                               43.21 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38277 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.051 
_reflns.pdbx_Rpim_I_all                                0.020 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       256607 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.047 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.59 
_reflns_shell.d_res_low                                     1.62 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           13409 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1904 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               7.0 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.1 
_reflns_shell.pdbx_Rrim_I_all                               0.880 
_reflns_shell.pdbx_Rpim_I_all                               0.330 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.816 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.815 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               31.42 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YT9 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.59 
_refine.ls_d_res_low                             39.67 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38253 
_refine.ls_number_reflns_R_free                  3760 
_refine.ls_number_reflns_R_work                  34493 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.80 
_refine.ls_percent_reflns_R_free                 9.83 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1862 
_refine.ls_R_factor_R_free                       0.2065 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1839 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.6925 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1981 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.59 
_refine_hist.d_res_low                        39.67 
_refine_hist.number_atoms_solvent             193 
_refine_hist.number_atoms_total               2333 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2101 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         39 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0104  ? 2180 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1262  ? 2936 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0585  ? 335  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0081  ? 365  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 23.5821 ? 816  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.59 1.61  . . 146 1299 99.93  . . . . 0.2857 . . . . . . . . . . . 0.3304 
'X-RAY DIFFRACTION' 1.61 1.63  . . 130 1243 100.00 . . . . 0.2627 . . . . . . . . . . . 0.3447 
'X-RAY DIFFRACTION' 1.63 1.65  . . 148 1289 100.00 . . . . 0.2543 . . . . . . . . . . . 0.2677 
'X-RAY DIFFRACTION' 1.65 1.68  . . 138 1284 100.00 . . . . 0.2532 . . . . . . . . . . . 0.2860 
'X-RAY DIFFRACTION' 1.68 1.70  . . 143 1254 100.00 . . . . 0.2380 . . . . . . . . . . . 0.2336 
'X-RAY DIFFRACTION' 1.70 1.73  . . 135 1277 100.00 . . . . 0.2236 . . . . . . . . . . . 0.2827 
'X-RAY DIFFRACTION' 1.73 1.76  . . 139 1254 100.00 . . . . 0.2196 . . . . . . . . . . . 0.2667 
'X-RAY DIFFRACTION' 1.76 1.79  . . 143 1309 100.00 . . . . 0.2250 . . . . . . . . . . . 0.2722 
'X-RAY DIFFRACTION' 1.79 1.82  . . 137 1248 100.00 . . . . 0.2355 . . . . . . . . . . . 0.2702 
'X-RAY DIFFRACTION' 1.82 1.86  . . 129 1279 100.00 . . . . 0.2346 . . . . . . . . . . . 0.2584 
'X-RAY DIFFRACTION' 1.86 1.89  . . 149 1269 100.00 . . . . 0.2416 . . . . . . . . . . . 0.2577 
'X-RAY DIFFRACTION' 1.89 1.93  . . 151 1263 99.79  . . . . 0.2411 . . . . . . . . . . . 0.2906 
'X-RAY DIFFRACTION' 1.93 1.98  . . 143 1277 99.79  . . . . 0.2229 . . . . . . . . . . . 0.2730 
'X-RAY DIFFRACTION' 1.98 2.03  . . 148 1262 100.00 . . . . 0.2129 . . . . . . . . . . . 0.2345 
'X-RAY DIFFRACTION' 2.03 2.08  . . 145 1259 99.93  . . . . 0.1995 . . . . . . . . . . . 0.2571 
'X-RAY DIFFRACTION' 2.08 2.14  . . 141 1291 100.00 . . . . 0.1943 . . . . . . . . . . . 0.2150 
'X-RAY DIFFRACTION' 2.14 2.21  . . 142 1271 100.00 . . . . 0.1811 . . . . . . . . . . . 0.2272 
'X-RAY DIFFRACTION' 2.21 2.29  . . 135 1259 98.59  . . . . 0.1933 . . . . . . . . . . . 0.2106 
'X-RAY DIFFRACTION' 2.29 2.38  . . 141 1268 99.86  . . . . 0.1856 . . . . . . . . . . . 0.1783 
'X-RAY DIFFRACTION' 2.38 2.49  . . 111 1315 99.72  . . . . 0.1799 . . . . . . . . . . . 0.2216 
'X-RAY DIFFRACTION' 2.49 2.62  . . 144 1265 99.79  . . . . 0.1878 . . . . . . . . . . . 0.2211 
'X-RAY DIFFRACTION' 2.62 2.79  . . 132 1276 99.22  . . . . 0.1875 . . . . . . . . . . . 0.1828 
'X-RAY DIFFRACTION' 2.79 3.00  . . 145 1273 99.44  . . . . 0.1827 . . . . . . . . . . . 0.2162 
'X-RAY DIFFRACTION' 3.00 3.31  . . 127 1303 99.86  . . . . 0.1801 . . . . . . . . . . . 0.1725 
'X-RAY DIFFRACTION' 3.31 3.78  . . 132 1299 99.86  . . . . 0.1601 . . . . . . . . . . . 0.1539 
'X-RAY DIFFRACTION' 3.78 4.77  . . 143 1284 99.72  . . . . 0.1477 . . . . . . . . . . . 0.1825 
'X-RAY DIFFRACTION' 4.77 39.67 . . 143 1323 99.26  . . . . 0.1687 . . . . . . . . . . . 0.1899 
# 
_struct.entry_id                     8YT9 
_struct.title                        
'Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YT9 
_struct_keywords.text            'Agonist, Complex, Nuclear receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARA_HUMAN Q07869 ? 1 
;TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
;
200 
2 UNP PRGC1_HUMAN Q9UBK2 ? 2 PQEAEEPSLLKKLLLAPANTQL 135 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YT9 A 4 ? 272 ? Q07869 200 ? 468 ? 200 468 
2 2 8YT9 B 1 ? 22  ? Q9UBK2 135 ? 156 ? 135 156 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YT9 GLY A 1 ? UNP Q07869 ? ? 'expression tag' 197 1 
1 8YT9 GLY A 2 ? UNP Q07869 ? ? 'expression tag' 198 2 
1 8YT9 GLN A 3 ? UNP Q07869 ? ? 'expression tag' 199 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1040  ? 
1 MORE         -9    ? 
1 'SSA (A^2)'  12660 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 6   ? PHE A 22  ? ASP A 202 PHE A 218 1 ? 17 
HELX_P HELX_P2  AA2 ASN A 25  ? LEU A 33  ? ASN A 221 LEU A 229 1 ? 9  
HELX_P HELX_P3  AA3 ASP A 47  ? VAL A 59  ? ASP A 243 VAL A 255 1 ? 13 
HELX_P HELX_P4  AA4 GLU A 71  ? ILE A 98  ? GLU A 267 ILE A 294 1 ? 28 
HELX_P HELX_P5  AA5 GLY A 100 ? LEU A 104 ? GLY A 296 LEU A 300 5 ? 5  
HELX_P HELX_P6  AA6 ASP A 105 ? SER A 126 ? ASP A 301 SER A 322 1 ? 22 
HELX_P HELX_P7  AA7 ARG A 145 ? LEU A 151 ? ARG A 341 LEU A 347 1 ? 7  
HELX_P HELX_P8  AA8 PRO A 154 ? ILE A 158 ? PRO A 350 ILE A 354 5 ? 5  
HELX_P HELX_P9  AA9 MET A 159 ? ALA A 171 ? MET A 355 ALA A 367 1 ? 13 
HELX_P HELX_P10 AB1 ASP A 175 ? CYS A 188 ? ASP A 371 CYS A 384 1 ? 14 
HELX_P HELX_P11 AB2 ASN A 197 ? HIS A 220 ? ASN A 393 HIS A 416 1 ? 24 
HELX_P HELX_P12 AB3 PHE A 225 ? GLU A 255 ? PHE A 421 GLU A 451 1 ? 31 
HELX_P HELX_P13 AB4 HIS A 261 ? ARG A 269 ? HIS A 457 ARG A 465 1 ? 9  
HELX_P HELX_P14 AB5 SER B 8   ? ALA B 16  ? SER B 142 ALA B 150 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           153 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            349 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    154 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     350 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       3.61 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   4 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 43  ? ILE A 45  ? PHE A 239 ILE A 241 
AA1 2 GLY A 141 ? THR A 144 ? GLY A 337 THR A 340 
AA1 3 GLY A 133 ? VAL A 136 ? GLY A 329 VAL A 332 
AA1 4 MET A 129 ? ASN A 130 ? MET A 325 ASN A 326 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 45  ? N ILE A 241 O PHE A 142 ? O PHE A 338 
AA1 2 3 O GLY A 141 ? O GLY A 337 N VAL A 136 ? N VAL A 332 
AA1 3 4 O GLY A 133 ? O GLY A 329 N ASN A 130 ? N ASN A 326 
# 
_pdbx_entry_details.entry_id                   8YT9 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OG 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    SER 
_pdbx_validate_symm_contact.auth_seq_id_1     414 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OD1 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    ASP 
_pdbx_validate_symm_contact.auth_seq_id_2     466 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_455 
_pdbx_validate_symm_contact.dist              2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 229 ? ? -72.43  30.24   
2 1 SER A 230 ? ? -149.34 -156.44 
3 1 ASN A 393 ? ? -113.48 62.85   
4 1 ALA A 454 ? ? -109.69 78.89   
5 1 MET A 467 ? ? -63.89  -76.36  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 197 ? A GLY 1  
2  1 Y 1 A GLY 198 ? A GLY 2  
3  1 Y 1 A GLN 199 ? A GLN 3  
4  1 Y 1 A THR 200 ? A THR 4  
5  1 Y 1 A ALA 201 ? A ALA 5  
6  1 Y 1 A LYS 232 ? A LYS 36 
7  1 Y 1 A ALA 233 ? A ALA 37 
8  1 Y 1 A SER 234 ? A SER 38 
9  1 Y 1 A ASN 235 ? A ASN 39 
10 1 Y 1 A ASN 236 ? A ASN 40 
11 1 Y 1 A LEU 258 ? A LEU 62 
12 1 Y 1 A VAL 259 ? A VAL 63 
13 1 Y 1 A ALA 260 ? A ALA 64 
14 1 Y 1 A ASN 261 ? A ASN 65 
15 1 Y 1 A GLY 262 ? A GLY 66 
16 1 Y 1 A ILE 263 ? A ILE 67 
17 1 Y 1 A GLN 264 ? A GLN 68 
18 1 Y 1 A ASN 265 ? A ASN 69 
19 1 Y 1 B PRO 135 ? B PRO 1  
20 1 Y 1 B GLN 136 ? B GLN 2  
21 1 Y 1 B GLU 137 ? B GLU 3  
22 1 Y 1 B ALA 138 ? B ALA 4  
23 1 Y 1 B GLU 139 ? B GLU 5  
24 1 Y 1 B GLU 140 ? B GLU 6  
25 1 Y 1 B PRO 151 ? B PRO 17 
26 1 Y 1 B ALA 152 ? B ALA 18 
27 1 Y 1 B ASN 153 ? B ASN 19 
28 1 Y 1 B THR 154 ? B THR 20 
29 1 Y 1 B GLN 155 ? B GLN 21 
30 1 Y 1 B LEU 156 ? B LEU 22 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LZY C01  C Y N 1   
A1LZY C02  C Y N 2   
A1LZY C03  C Y N 3   
A1LZY C04  C Y N 4   
A1LZY C05  C Y N 5   
A1LZY C06  C Y N 6   
A1LZY C07  C N N 7   
A1LZY C08  C N N 8   
A1LZY C09  C N N 9   
A1LZY C10  C N N 10  
A1LZY C11  C N N 11  
A1LZY C12  C N N 12  
A1LZY C13  C Y N 13  
A1LZY C14  C Y N 14  
A1LZY C15  C Y N 15  
A1LZY C16  C Y N 16  
A1LZY C17  C Y N 17  
A1LZY C18  C Y N 18  
A1LZY C26  C N N 19  
A1LZY C27  C N N 20  
A1LZY C28  C Y N 21  
A1LZY C29  C Y N 22  
A1LZY C31  C Y N 23  
A1LZY C33  C Y N 24  
A1LZY C34  C Y N 25  
A1LZY C35  C Y N 26  
A1LZY C36  C Y N 27  
A1LZY C37  C Y N 28  
A1LZY C38  C Y N 29  
A1LZY C39  C N N 30  
A1LZY F19  F N N 31  
A1LZY N20  N Y N 32  
A1LZY N21  N Y N 33  
A1LZY N22  N Y N 34  
A1LZY N32  N Y N 35  
A1LZY O23  O N N 36  
A1LZY O24  O N N 37  
A1LZY O25  O N N 38  
A1LZY O30  O Y N 39  
A1LZY H1   H N N 40  
A1LZY H2   H N N 41  
A1LZY H3   H N N 42  
A1LZY H4   H N N 43  
A1LZY H5   H N N 44  
A1LZY H6   H N N 45  
A1LZY H7   H N N 46  
A1LZY H8   H N N 47  
A1LZY H9   H N N 48  
A1LZY H10  H N N 49  
A1LZY H11  H N N 50  
A1LZY H12  H N N 51  
A1LZY H13  H N N 52  
A1LZY H14  H N N 53  
A1LZY H15  H N N 54  
A1LZY H16  H N N 55  
A1LZY H17  H N N 56  
A1LZY H18  H N N 57  
A1LZY H19  H N N 58  
A1LZY H20  H N N 59  
A1LZY H21  H N N 60  
A1LZY H22  H N N 61  
A1LZY H23  H N N 62  
A1LZY H24  H N N 63  
A1LZY H25  H N N 64  
A1LZY H26  H N N 65  
A1LZY H27  H N N 66  
A1LZY H28  H N N 67  
A1LZY H29  H N N 68  
ALA   N    N N N 69  
ALA   CA   C N S 70  
ALA   C    C N N 71  
ALA   O    O N N 72  
ALA   CB   C N N 73  
ALA   OXT  O N N 74  
ALA   H    H N N 75  
ALA   H2   H N N 76  
ALA   HA   H N N 77  
ALA   HB1  H N N 78  
ALA   HB2  H N N 79  
ALA   HB3  H N N 80  
ALA   HXT  H N N 81  
ARG   N    N N N 82  
ARG   CA   C N S 83  
ARG   C    C N N 84  
ARG   O    O N N 85  
ARG   CB   C N N 86  
ARG   CG   C N N 87  
ARG   CD   C N N 88  
ARG   NE   N N N 89  
ARG   CZ   C N N 90  
ARG   NH1  N N N 91  
ARG   NH2  N N N 92  
ARG   OXT  O N N 93  
ARG   H    H N N 94  
ARG   H2   H N N 95  
ARG   HA   H N N 96  
ARG   HB2  H N N 97  
ARG   HB3  H N N 98  
ARG   HG2  H N N 99  
ARG   HG3  H N N 100 
ARG   HD2  H N N 101 
ARG   HD3  H N N 102 
ARG   HE   H N N 103 
ARG   HH11 H N N 104 
ARG   HH12 H N N 105 
ARG   HH21 H N N 106 
ARG   HH22 H N N 107 
ARG   HXT  H N N 108 
ASN   N    N N N 109 
ASN   CA   C N S 110 
ASN   C    C N N 111 
ASN   O    O N N 112 
ASN   CB   C N N 113 
ASN   CG   C N N 114 
ASN   OD1  O N N 115 
ASN   ND2  N N N 116 
ASN   OXT  O N N 117 
ASN   H    H N N 118 
ASN   H2   H N N 119 
ASN   HA   H N N 120 
ASN   HB2  H N N 121 
ASN   HB3  H N N 122 
ASN   HD21 H N N 123 
ASN   HD22 H N N 124 
ASN   HXT  H N N 125 
ASP   N    N N N 126 
ASP   CA   C N S 127 
ASP   C    C N N 128 
ASP   O    O N N 129 
ASP   CB   C N N 130 
ASP   CG   C N N 131 
ASP   OD1  O N N 132 
ASP   OD2  O N N 133 
ASP   OXT  O N N 134 
ASP   H    H N N 135 
ASP   H2   H N N 136 
ASP   HA   H N N 137 
ASP   HB2  H N N 138 
ASP   HB3  H N N 139 
ASP   HD2  H N N 140 
ASP   HXT  H N N 141 
CYS   N    N N N 142 
CYS   CA   C N R 143 
CYS   C    C N N 144 
CYS   O    O N N 145 
CYS   CB   C N N 146 
CYS   SG   S N N 147 
CYS   OXT  O N N 148 
CYS   H    H N N 149 
CYS   H2   H N N 150 
CYS   HA   H N N 151 
CYS   HB2  H N N 152 
CYS   HB3  H N N 153 
CYS   HG   H N N 154 
CYS   HXT  H N N 155 
GLN   N    N N N 156 
GLN   CA   C N S 157 
GLN   C    C N N 158 
GLN   O    O N N 159 
GLN   CB   C N N 160 
GLN   CG   C N N 161 
GLN   CD   C N N 162 
GLN   OE1  O N N 163 
GLN   NE2  N N N 164 
GLN   OXT  O N N 165 
GLN   H    H N N 166 
GLN   H2   H N N 167 
GLN   HA   H N N 168 
GLN   HB2  H N N 169 
GLN   HB3  H N N 170 
GLN   HG2  H N N 171 
GLN   HG3  H N N 172 
GLN   HE21 H N N 173 
GLN   HE22 H N N 174 
GLN   HXT  H N N 175 
GLU   N    N N N 176 
GLU   CA   C N S 177 
GLU   C    C N N 178 
GLU   O    O N N 179 
GLU   CB   C N N 180 
GLU   CG   C N N 181 
GLU   CD   C N N 182 
GLU   OE1  O N N 183 
GLU   OE2  O N N 184 
GLU   OXT  O N N 185 
GLU   H    H N N 186 
GLU   H2   H N N 187 
GLU   HA   H N N 188 
GLU   HB2  H N N 189 
GLU   HB3  H N N 190 
GLU   HG2  H N N 191 
GLU   HG3  H N N 192 
GLU   HE2  H N N 193 
GLU   HXT  H N N 194 
GLY   N    N N N 195 
GLY   CA   C N N 196 
GLY   C    C N N 197 
GLY   O    O N N 198 
GLY   OXT  O N N 199 
GLY   H    H N N 200 
GLY   H2   H N N 201 
GLY   HA2  H N N 202 
GLY   HA3  H N N 203 
GLY   HXT  H N N 204 
HIS   N    N N N 205 
HIS   CA   C N S 206 
HIS   C    C N N 207 
HIS   O    O N N 208 
HIS   CB   C N N 209 
HIS   CG   C Y N 210 
HIS   ND1  N Y N 211 
HIS   CD2  C Y N 212 
HIS   CE1  C Y N 213 
HIS   NE2  N Y N 214 
HIS   OXT  O N N 215 
HIS   H    H N N 216 
HIS   H2   H N N 217 
HIS   HA   H N N 218 
HIS   HB2  H N N 219 
HIS   HB3  H N N 220 
HIS   HD1  H N N 221 
HIS   HD2  H N N 222 
HIS   HE1  H N N 223 
HIS   HE2  H N N 224 
HIS   HXT  H N N 225 
HOH   O    O N N 226 
HOH   H1   H N N 227 
HOH   H2   H N N 228 
ILE   N    N N N 229 
ILE   CA   C N S 230 
ILE   C    C N N 231 
ILE   O    O N N 232 
ILE   CB   C N S 233 
ILE   CG1  C N N 234 
ILE   CG2  C N N 235 
ILE   CD1  C N N 236 
ILE   OXT  O N N 237 
ILE   H    H N N 238 
ILE   H2   H N N 239 
ILE   HA   H N N 240 
ILE   HB   H N N 241 
ILE   HG12 H N N 242 
ILE   HG13 H N N 243 
ILE   HG21 H N N 244 
ILE   HG22 H N N 245 
ILE   HG23 H N N 246 
ILE   HD11 H N N 247 
ILE   HD12 H N N 248 
ILE   HD13 H N N 249 
ILE   HXT  H N N 250 
LEU   N    N N N 251 
LEU   CA   C N S 252 
LEU   C    C N N 253 
LEU   O    O N N 254 
LEU   CB   C N N 255 
LEU   CG   C N N 256 
LEU   CD1  C N N 257 
LEU   CD2  C N N 258 
LEU   OXT  O N N 259 
LEU   H    H N N 260 
LEU   H2   H N N 261 
LEU   HA   H N N 262 
LEU   HB2  H N N 263 
LEU   HB3  H N N 264 
LEU   HG   H N N 265 
LEU   HD11 H N N 266 
LEU   HD12 H N N 267 
LEU   HD13 H N N 268 
LEU   HD21 H N N 269 
LEU   HD22 H N N 270 
LEU   HD23 H N N 271 
LEU   HXT  H N N 272 
LYS   N    N N N 273 
LYS   CA   C N S 274 
LYS   C    C N N 275 
LYS   O    O N N 276 
LYS   CB   C N N 277 
LYS   CG   C N N 278 
LYS   CD   C N N 279 
LYS   CE   C N N 280 
LYS   NZ   N N N 281 
LYS   OXT  O N N 282 
LYS   H    H N N 283 
LYS   H2   H N N 284 
LYS   HA   H N N 285 
LYS   HB2  H N N 286 
LYS   HB3  H N N 287 
LYS   HG2  H N N 288 
LYS   HG3  H N N 289 
LYS   HD2  H N N 290 
LYS   HD3  H N N 291 
LYS   HE2  H N N 292 
LYS   HE3  H N N 293 
LYS   HZ1  H N N 294 
LYS   HZ2  H N N 295 
LYS   HZ3  H N N 296 
LYS   HXT  H N N 297 
MET   N    N N N 298 
MET   CA   C N S 299 
MET   C    C N N 300 
MET   O    O N N 301 
MET   CB   C N N 302 
MET   CG   C N N 303 
MET   SD   S N N 304 
MET   CE   C N N 305 
MET   OXT  O N N 306 
MET   H    H N N 307 
MET   H2   H N N 308 
MET   HA   H N N 309 
MET   HB2  H N N 310 
MET   HB3  H N N 311 
MET   HG2  H N N 312 
MET   HG3  H N N 313 
MET   HE1  H N N 314 
MET   HE2  H N N 315 
MET   HE3  H N N 316 
MET   HXT  H N N 317 
PHE   N    N N N 318 
PHE   CA   C N S 319 
PHE   C    C N N 320 
PHE   O    O N N 321 
PHE   CB   C N N 322 
PHE   CG   C Y N 323 
PHE   CD1  C Y N 324 
PHE   CD2  C Y N 325 
PHE   CE1  C Y N 326 
PHE   CE2  C Y N 327 
PHE   CZ   C Y N 328 
PHE   OXT  O N N 329 
PHE   H    H N N 330 
PHE   H2   H N N 331 
PHE   HA   H N N 332 
PHE   HB2  H N N 333 
PHE   HB3  H N N 334 
PHE   HD1  H N N 335 
PHE   HD2  H N N 336 
PHE   HE1  H N N 337 
PHE   HE2  H N N 338 
PHE   HZ   H N N 339 
PHE   HXT  H N N 340 
PRO   N    N N N 341 
PRO   CA   C N S 342 
PRO   C    C N N 343 
PRO   O    O N N 344 
PRO   CB   C N N 345 
PRO   CG   C N N 346 
PRO   CD   C N N 347 
PRO   OXT  O N N 348 
PRO   H    H N N 349 
PRO   HA   H N N 350 
PRO   HB2  H N N 351 
PRO   HB3  H N N 352 
PRO   HG2  H N N 353 
PRO   HG3  H N N 354 
PRO   HD2  H N N 355 
PRO   HD3  H N N 356 
PRO   HXT  H N N 357 
SER   N    N N N 358 
SER   CA   C N S 359 
SER   C    C N N 360 
SER   O    O N N 361 
SER   CB   C N N 362 
SER   OG   O N N 363 
SER   OXT  O N N 364 
SER   H    H N N 365 
SER   H2   H N N 366 
SER   HA   H N N 367 
SER   HB2  H N N 368 
SER   HB3  H N N 369 
SER   HG   H N N 370 
SER   HXT  H N N 371 
THR   N    N N N 372 
THR   CA   C N S 373 
THR   C    C N N 374 
THR   O    O N N 375 
THR   CB   C N R 376 
THR   OG1  O N N 377 
THR   CG2  C N N 378 
THR   OXT  O N N 379 
THR   H    H N N 380 
THR   H2   H N N 381 
THR   HA   H N N 382 
THR   HB   H N N 383 
THR   HG1  H N N 384 
THR   HG21 H N N 385 
THR   HG22 H N N 386 
THR   HG23 H N N 387 
THR   HXT  H N N 388 
TYR   N    N N N 389 
TYR   CA   C N S 390 
TYR   C    C N N 391 
TYR   O    O N N 392 
TYR   CB   C N N 393 
TYR   CG   C Y N 394 
TYR   CD1  C Y N 395 
TYR   CD2  C Y N 396 
TYR   CE1  C Y N 397 
TYR   CE2  C Y N 398 
TYR   CZ   C Y N 399 
TYR   OH   O N N 400 
TYR   OXT  O N N 401 
TYR   H    H N N 402 
TYR   H2   H N N 403 
TYR   HA   H N N 404 
TYR   HB2  H N N 405 
TYR   HB3  H N N 406 
TYR   HD1  H N N 407 
TYR   HD2  H N N 408 
TYR   HE1  H N N 409 
TYR   HE2  H N N 410 
TYR   HH   H N N 411 
TYR   HXT  H N N 412 
VAL   N    N N N 413 
VAL   CA   C N S 414 
VAL   C    C N N 415 
VAL   O    O N N 416 
VAL   CB   C N N 417 
VAL   CG1  C N N 418 
VAL   CG2  C N N 419 
VAL   OXT  O N N 420 
VAL   H    H N N 421 
VAL   H2   H N N 422 
VAL   HA   H N N 423 
VAL   HB   H N N 424 
VAL   HG11 H N N 425 
VAL   HG12 H N N 426 
VAL   HG13 H N N 427 
VAL   HG21 H N N 428 
VAL   HG22 H N N 429 
VAL   HG23 H N N 430 
VAL   HXT  H N N 431 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LZY C01 C02  doub Y N 1   
A1LZY C01 N20  sing Y N 2   
A1LZY C02 C03  sing Y N 3   
A1LZY C03 C04  doub Y N 4   
A1LZY C03 C07  sing N N 5   
A1LZY C04 C05  sing Y N 6   
A1LZY C04 C06  sing Y N 7   
A1LZY C05 N20  doub Y N 8   
A1LZY C05 N22  sing Y N 9   
A1LZY C06 C08  sing N N 10  
A1LZY C06 N21  doub Y N 11  
A1LZY C07 O23  doub N N 12  
A1LZY C07 O24  sing N N 13  
A1LZY C08 C09  sing N N 14  
A1LZY C08 C10  sing N N 15  
A1LZY C09 C11  sing N N 16  
A1LZY C10 C12  sing N N 17  
A1LZY C13 C14  doub Y N 18  
A1LZY C13 C18  sing Y N 19  
A1LZY C14 C15  sing Y N 20  
A1LZY C15 C16  doub Y N 21  
A1LZY C15 F19  sing N N 22  
A1LZY C16 C17  sing Y N 23  
A1LZY C17 C18  doub Y N 24  
A1LZY C18 N22  sing N N 25  
A1LZY N21 N22  sing Y N 26  
A1LZY O25 C26  sing N N 27  
A1LZY C27 C28  sing N N 28  
A1LZY C29 O30  sing Y N 29  
A1LZY O30 C31  sing Y N 30  
A1LZY C31 N32  doub Y N 31  
A1LZY C28 C29  doub Y N 32  
A1LZY C28 N32  sing Y N 33  
A1LZY C31 C33  sing N N 34  
A1LZY C34 C35  doub Y N 35  
A1LZY C35 C36  sing Y N 36  
A1LZY C36 C37  doub Y N 37  
A1LZY C37 C38  sing Y N 38  
A1LZY C33 C34  sing Y N 39  
A1LZY C33 C38  doub Y N 40  
A1LZY C29 C39  sing N N 41  
A1LZY C26 C27  sing N N 42  
A1LZY C01 O25  sing N N 43  
A1LZY C02 H1   sing N N 44  
A1LZY C08 H2   sing N N 45  
A1LZY C09 H3   sing N N 46  
A1LZY C09 H4   sing N N 47  
A1LZY C10 H5   sing N N 48  
A1LZY C10 H6   sing N N 49  
A1LZY C11 H7   sing N N 50  
A1LZY C11 H8   sing N N 51  
A1LZY C11 H9   sing N N 52  
A1LZY C12 H10  sing N N 53  
A1LZY C12 H11  sing N N 54  
A1LZY C12 H12  sing N N 55  
A1LZY C13 H13  sing N N 56  
A1LZY C14 H14  sing N N 57  
A1LZY C16 H15  sing N N 58  
A1LZY C17 H16  sing N N 59  
A1LZY C26 H17  sing N N 60  
A1LZY C26 H18  sing N N 61  
A1LZY C27 H19  sing N N 62  
A1LZY C27 H20  sing N N 63  
A1LZY C34 H21  sing N N 64  
A1LZY C35 H22  sing N N 65  
A1LZY C36 H23  sing N N 66  
A1LZY C37 H24  sing N N 67  
A1LZY C38 H25  sing N N 68  
A1LZY C39 H26  sing N N 69  
A1LZY C39 H27  sing N N 70  
A1LZY C39 H28  sing N N 71  
A1LZY O24 H29  sing N N 72  
ALA   N   CA   sing N N 73  
ALA   N   H    sing N N 74  
ALA   N   H2   sing N N 75  
ALA   CA  C    sing N N 76  
ALA   CA  CB   sing N N 77  
ALA   CA  HA   sing N N 78  
ALA   C   O    doub N N 79  
ALA   C   OXT  sing N N 80  
ALA   CB  HB1  sing N N 81  
ALA   CB  HB2  sing N N 82  
ALA   CB  HB3  sing N N 83  
ALA   OXT HXT  sing N N 84  
ARG   N   CA   sing N N 85  
ARG   N   H    sing N N 86  
ARG   N   H2   sing N N 87  
ARG   CA  C    sing N N 88  
ARG   CA  CB   sing N N 89  
ARG   CA  HA   sing N N 90  
ARG   C   O    doub N N 91  
ARG   C   OXT  sing N N 92  
ARG   CB  CG   sing N N 93  
ARG   CB  HB2  sing N N 94  
ARG   CB  HB3  sing N N 95  
ARG   CG  CD   sing N N 96  
ARG   CG  HG2  sing N N 97  
ARG   CG  HG3  sing N N 98  
ARG   CD  NE   sing N N 99  
ARG   CD  HD2  sing N N 100 
ARG   CD  HD3  sing N N 101 
ARG   NE  CZ   sing N N 102 
ARG   NE  HE   sing N N 103 
ARG   CZ  NH1  sing N N 104 
ARG   CZ  NH2  doub N N 105 
ARG   NH1 HH11 sing N N 106 
ARG   NH1 HH12 sing N N 107 
ARG   NH2 HH21 sing N N 108 
ARG   NH2 HH22 sing N N 109 
ARG   OXT HXT  sing N N 110 
ASN   N   CA   sing N N 111 
ASN   N   H    sing N N 112 
ASN   N   H2   sing N N 113 
ASN   CA  C    sing N N 114 
ASN   CA  CB   sing N N 115 
ASN   CA  HA   sing N N 116 
ASN   C   O    doub N N 117 
ASN   C   OXT  sing N N 118 
ASN   CB  CG   sing N N 119 
ASN   CB  HB2  sing N N 120 
ASN   CB  HB3  sing N N 121 
ASN   CG  OD1  doub N N 122 
ASN   CG  ND2  sing N N 123 
ASN   ND2 HD21 sing N N 124 
ASN   ND2 HD22 sing N N 125 
ASN   OXT HXT  sing N N 126 
ASP   N   CA   sing N N 127 
ASP   N   H    sing N N 128 
ASP   N   H2   sing N N 129 
ASP   CA  C    sing N N 130 
ASP   CA  CB   sing N N 131 
ASP   CA  HA   sing N N 132 
ASP   C   O    doub N N 133 
ASP   C   OXT  sing N N 134 
ASP   CB  CG   sing N N 135 
ASP   CB  HB2  sing N N 136 
ASP   CB  HB3  sing N N 137 
ASP   CG  OD1  doub N N 138 
ASP   CG  OD2  sing N N 139 
ASP   OD2 HD2  sing N N 140 
ASP   OXT HXT  sing N N 141 
CYS   N   CA   sing N N 142 
CYS   N   H    sing N N 143 
CYS   N   H2   sing N N 144 
CYS   CA  C    sing N N 145 
CYS   CA  CB   sing N N 146 
CYS   CA  HA   sing N N 147 
CYS   C   O    doub N N 148 
CYS   C   OXT  sing N N 149 
CYS   CB  SG   sing N N 150 
CYS   CB  HB2  sing N N 151 
CYS   CB  HB3  sing N N 152 
CYS   SG  HG   sing N N 153 
CYS   OXT HXT  sing N N 154 
GLN   N   CA   sing N N 155 
GLN   N   H    sing N N 156 
GLN   N   H2   sing N N 157 
GLN   CA  C    sing N N 158 
GLN   CA  CB   sing N N 159 
GLN   CA  HA   sing N N 160 
GLN   C   O    doub N N 161 
GLN   C   OXT  sing N N 162 
GLN   CB  CG   sing N N 163 
GLN   CB  HB2  sing N N 164 
GLN   CB  HB3  sing N N 165 
GLN   CG  CD   sing N N 166 
GLN   CG  HG2  sing N N 167 
GLN   CG  HG3  sing N N 168 
GLN   CD  OE1  doub N N 169 
GLN   CD  NE2  sing N N 170 
GLN   NE2 HE21 sing N N 171 
GLN   NE2 HE22 sing N N 172 
GLN   OXT HXT  sing N N 173 
GLU   N   CA   sing N N 174 
GLU   N   H    sing N N 175 
GLU   N   H2   sing N N 176 
GLU   CA  C    sing N N 177 
GLU   CA  CB   sing N N 178 
GLU   CA  HA   sing N N 179 
GLU   C   O    doub N N 180 
GLU   C   OXT  sing N N 181 
GLU   CB  CG   sing N N 182 
GLU   CB  HB2  sing N N 183 
GLU   CB  HB3  sing N N 184 
GLU   CG  CD   sing N N 185 
GLU   CG  HG2  sing N N 186 
GLU   CG  HG3  sing N N 187 
GLU   CD  OE1  doub N N 188 
GLU   CD  OE2  sing N N 189 
GLU   OE2 HE2  sing N N 190 
GLU   OXT HXT  sing N N 191 
GLY   N   CA   sing N N 192 
GLY   N   H    sing N N 193 
GLY   N   H2   sing N N 194 
GLY   CA  C    sing N N 195 
GLY   CA  HA2  sing N N 196 
GLY   CA  HA3  sing N N 197 
GLY   C   O    doub N N 198 
GLY   C   OXT  sing N N 199 
GLY   OXT HXT  sing N N 200 
HIS   N   CA   sing N N 201 
HIS   N   H    sing N N 202 
HIS   N   H2   sing N N 203 
HIS   CA  C    sing N N 204 
HIS   CA  CB   sing N N 205 
HIS   CA  HA   sing N N 206 
HIS   C   O    doub N N 207 
HIS   C   OXT  sing N N 208 
HIS   CB  CG   sing N N 209 
HIS   CB  HB2  sing N N 210 
HIS   CB  HB3  sing N N 211 
HIS   CG  ND1  sing Y N 212 
HIS   CG  CD2  doub Y N 213 
HIS   ND1 CE1  doub Y N 214 
HIS   ND1 HD1  sing N N 215 
HIS   CD2 NE2  sing Y N 216 
HIS   CD2 HD2  sing N N 217 
HIS   CE1 NE2  sing Y N 218 
HIS   CE1 HE1  sing N N 219 
HIS   NE2 HE2  sing N N 220 
HIS   OXT HXT  sing N N 221 
HOH   O   H1   sing N N 222 
HOH   O   H2   sing N N 223 
ILE   N   CA   sing N N 224 
ILE   N   H    sing N N 225 
ILE   N   H2   sing N N 226 
ILE   CA  C    sing N N 227 
ILE   CA  CB   sing N N 228 
ILE   CA  HA   sing N N 229 
ILE   C   O    doub N N 230 
ILE   C   OXT  sing N N 231 
ILE   CB  CG1  sing N N 232 
ILE   CB  CG2  sing N N 233 
ILE   CB  HB   sing N N 234 
ILE   CG1 CD1  sing N N 235 
ILE   CG1 HG12 sing N N 236 
ILE   CG1 HG13 sing N N 237 
ILE   CG2 HG21 sing N N 238 
ILE   CG2 HG22 sing N N 239 
ILE   CG2 HG23 sing N N 240 
ILE   CD1 HD11 sing N N 241 
ILE   CD1 HD12 sing N N 242 
ILE   CD1 HD13 sing N N 243 
ILE   OXT HXT  sing N N 244 
LEU   N   CA   sing N N 245 
LEU   N   H    sing N N 246 
LEU   N   H2   sing N N 247 
LEU   CA  C    sing N N 248 
LEU   CA  CB   sing N N 249 
LEU   CA  HA   sing N N 250 
LEU   C   O    doub N N 251 
LEU   C   OXT  sing N N 252 
LEU   CB  CG   sing N N 253 
LEU   CB  HB2  sing N N 254 
LEU   CB  HB3  sing N N 255 
LEU   CG  CD1  sing N N 256 
LEU   CG  CD2  sing N N 257 
LEU   CG  HG   sing N N 258 
LEU   CD1 HD11 sing N N 259 
LEU   CD1 HD12 sing N N 260 
LEU   CD1 HD13 sing N N 261 
LEU   CD2 HD21 sing N N 262 
LEU   CD2 HD22 sing N N 263 
LEU   CD2 HD23 sing N N 264 
LEU   OXT HXT  sing N N 265 
LYS   N   CA   sing N N 266 
LYS   N   H    sing N N 267 
LYS   N   H2   sing N N 268 
LYS   CA  C    sing N N 269 
LYS   CA  CB   sing N N 270 
LYS   CA  HA   sing N N 271 
LYS   C   O    doub N N 272 
LYS   C   OXT  sing N N 273 
LYS   CB  CG   sing N N 274 
LYS   CB  HB2  sing N N 275 
LYS   CB  HB3  sing N N 276 
LYS   CG  CD   sing N N 277 
LYS   CG  HG2  sing N N 278 
LYS   CG  HG3  sing N N 279 
LYS   CD  CE   sing N N 280 
LYS   CD  HD2  sing N N 281 
LYS   CD  HD3  sing N N 282 
LYS   CE  NZ   sing N N 283 
LYS   CE  HE2  sing N N 284 
LYS   CE  HE3  sing N N 285 
LYS   NZ  HZ1  sing N N 286 
LYS   NZ  HZ2  sing N N 287 
LYS   NZ  HZ3  sing N N 288 
LYS   OXT HXT  sing N N 289 
MET   N   CA   sing N N 290 
MET   N   H    sing N N 291 
MET   N   H2   sing N N 292 
MET   CA  C    sing N N 293 
MET   CA  CB   sing N N 294 
MET   CA  HA   sing N N 295 
MET   C   O    doub N N 296 
MET   C   OXT  sing N N 297 
MET   CB  CG   sing N N 298 
MET   CB  HB2  sing N N 299 
MET   CB  HB3  sing N N 300 
MET   CG  SD   sing N N 301 
MET   CG  HG2  sing N N 302 
MET   CG  HG3  sing N N 303 
MET   SD  CE   sing N N 304 
MET   CE  HE1  sing N N 305 
MET   CE  HE2  sing N N 306 
MET   CE  HE3  sing N N 307 
MET   OXT HXT  sing N N 308 
PHE   N   CA   sing N N 309 
PHE   N   H    sing N N 310 
PHE   N   H2   sing N N 311 
PHE   CA  C    sing N N 312 
PHE   CA  CB   sing N N 313 
PHE   CA  HA   sing N N 314 
PHE   C   O    doub N N 315 
PHE   C   OXT  sing N N 316 
PHE   CB  CG   sing N N 317 
PHE   CB  HB2  sing N N 318 
PHE   CB  HB3  sing N N 319 
PHE   CG  CD1  doub Y N 320 
PHE   CG  CD2  sing Y N 321 
PHE   CD1 CE1  sing Y N 322 
PHE   CD1 HD1  sing N N 323 
PHE   CD2 CE2  doub Y N 324 
PHE   CD2 HD2  sing N N 325 
PHE   CE1 CZ   doub Y N 326 
PHE   CE1 HE1  sing N N 327 
PHE   CE2 CZ   sing Y N 328 
PHE   CE2 HE2  sing N N 329 
PHE   CZ  HZ   sing N N 330 
PHE   OXT HXT  sing N N 331 
PRO   N   CA   sing N N 332 
PRO   N   CD   sing N N 333 
PRO   N   H    sing N N 334 
PRO   CA  C    sing N N 335 
PRO   CA  CB   sing N N 336 
PRO   CA  HA   sing N N 337 
PRO   C   O    doub N N 338 
PRO   C   OXT  sing N N 339 
PRO   CB  CG   sing N N 340 
PRO   CB  HB2  sing N N 341 
PRO   CB  HB3  sing N N 342 
PRO   CG  CD   sing N N 343 
PRO   CG  HG2  sing N N 344 
PRO   CG  HG3  sing N N 345 
PRO   CD  HD2  sing N N 346 
PRO   CD  HD3  sing N N 347 
PRO   OXT HXT  sing N N 348 
SER   N   CA   sing N N 349 
SER   N   H    sing N N 350 
SER   N   H2   sing N N 351 
SER   CA  C    sing N N 352 
SER   CA  CB   sing N N 353 
SER   CA  HA   sing N N 354 
SER   C   O    doub N N 355 
SER   C   OXT  sing N N 356 
SER   CB  OG   sing N N 357 
SER   CB  HB2  sing N N 358 
SER   CB  HB3  sing N N 359 
SER   OG  HG   sing N N 360 
SER   OXT HXT  sing N N 361 
THR   N   CA   sing N N 362 
THR   N   H    sing N N 363 
THR   N   H2   sing N N 364 
THR   CA  C    sing N N 365 
THR   CA  CB   sing N N 366 
THR   CA  HA   sing N N 367 
THR   C   O    doub N N 368 
THR   C   OXT  sing N N 369 
THR   CB  OG1  sing N N 370 
THR   CB  CG2  sing N N 371 
THR   CB  HB   sing N N 372 
THR   OG1 HG1  sing N N 373 
THR   CG2 HG21 sing N N 374 
THR   CG2 HG22 sing N N 375 
THR   CG2 HG23 sing N N 376 
THR   OXT HXT  sing N N 377 
TYR   N   CA   sing N N 378 
TYR   N   H    sing N N 379 
TYR   N   H2   sing N N 380 
TYR   CA  C    sing N N 381 
TYR   CA  CB   sing N N 382 
TYR   CA  HA   sing N N 383 
TYR   C   O    doub N N 384 
TYR   C   OXT  sing N N 385 
TYR   CB  CG   sing N N 386 
TYR   CB  HB2  sing N N 387 
TYR   CB  HB3  sing N N 388 
TYR   CG  CD1  doub Y N 389 
TYR   CG  CD2  sing Y N 390 
TYR   CD1 CE1  sing Y N 391 
TYR   CD1 HD1  sing N N 392 
TYR   CD2 CE2  doub Y N 393 
TYR   CD2 HD2  sing N N 394 
TYR   CE1 CZ   doub Y N 395 
TYR   CE1 HE1  sing N N 396 
TYR   CE2 CZ   sing Y N 397 
TYR   CE2 HE2  sing N N 398 
TYR   CZ  OH   sing N N 399 
TYR   OH  HH   sing N N 400 
TYR   OXT HXT  sing N N 401 
VAL   N   CA   sing N N 402 
VAL   N   H    sing N N 403 
VAL   N   H2   sing N N 404 
VAL   CA  C    sing N N 405 
VAL   CA  CB   sing N N 406 
VAL   CA  HA   sing N N 407 
VAL   C   O    doub N N 408 
VAL   C   OXT  sing N N 409 
VAL   CB  CG1  sing N N 410 
VAL   CB  CG2  sing N N 411 
VAL   CB  HB   sing N N 412 
VAL   CG1 HG11 sing N N 413 
VAL   CG1 HG12 sing N N 414 
VAL   CG1 HG13 sing N N 415 
VAL   CG2 HG21 sing N N 416 
VAL   CG2 HG22 sing N N 417 
VAL   CG2 HG23 sing N N 418 
VAL   OXT HXT  sing N N 419 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121054 1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121052 2 
'Japan Society for the Promotion of Science (JSPS)'        Japan 15H02896      3 
'Japan Society for the Promotion of Science (JSPS)'        Japan 16K13044      4 
'Japan Society for the Promotion of Science (JSPS)'        Japan 18H03190      5 
'Japan Society for the Promotion of Science (JSPS)'        Japan 21H03354      6 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6KXY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YT9 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022223 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.006452 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016012 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019473 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP   A 1 6   ? -4.59200  -9.80900  -1.77800  1.000 54.34559 ? 202 ASP   A N   1 
ATOM   2    C CA  . ASP   A 1 6   ? -5.43700  -9.46400  -2.91600  1.000 57.59334 ? 202 ASP   A CA  1 
ATOM   3    C C   . ASP   A 1 6   ? -4.82000  -9.94500  -4.24100  1.000 53.89623 ? 202 ASP   A C   1 
ATOM   4    O O   . ASP   A 1 6   ? -3.96400  -9.28600  -4.84600  1.000 47.60840 ? 202 ASP   A O   1 
ATOM   5    C CB  . ASP   A 1 6   ? -5.69400  -7.95800  -2.95000  1.000 59.41250 ? 202 ASP   A CB  1 
ATOM   6    C CG  . ASP   A 1 6   ? -6.88000  -7.58600  -3.83100  1.000 65.44623 ? 202 ASP   A CG  1 
ATOM   7    O OD1 . ASP   A 1 6   ? -7.39700  -8.46500  -4.56000  1.000 58.76675 ? 202 ASP   A OD1 1 
ATOM   8    O OD2 . ASP   A 1 6   ? -7.30500  -6.41100  -3.78000  1.000 71.95623 ? 202 ASP   A OD2 1 
ATOM   9    N N   . LEU   A 1 7   ? -5.28900  -11.10600 -4.69400  1.000 54.61623 ? 203 LEU   A N   1 
ATOM   10   C CA  . LEU   A 1 7   ? -4.68000  -11.75100 -5.85100  1.000 48.85857 ? 203 LEU   A CA  1 
ATOM   11   C C   . LEU   A 1 7   ? -5.02500  -11.02000 -7.14400  1.000 47.28623 ? 203 LEU   A C   1 
ATOM   12   O O   . LEU   A 1 7   ? -4.19400  -10.93300 -8.06300  1.000 39.22128 ? 203 LEU   A O   1 
ATOM   13   C CB  . LEU   A 1 7   ? -5.12500  -13.21400 -5.90200  1.000 53.85623 ? 203 LEU   A CB  1 
ATOM   14   C CG  . LEU   A 1 7   ? -4.92000  -13.90000 -4.54600  1.000 49.92239 ? 203 LEU   A CG  1 
ATOM   15   C CD1 . LEU   A 1 7   ? -6.00800  -14.92800 -4.24500  1.000 48.57680 ? 203 LEU   A CD1 1 
ATOM   16   C CD2 . LEU   A 1 7   ? -3.52700  -14.51200 -4.46900  1.000 49.00157 ? 203 LEU   A CD2 1 
ATOM   17   N N   . LYS   A 1 8   ? -6.24900  -10.48900 -7.23200  1.000 47.39786 ? 204 LYS   A N   1 
ATOM   18   C CA  . LYS   A 1 8   ? -6.64600  -9.71700  -8.40400  1.000 50.93623 ? 204 LYS   A CA  1 
ATOM   19   C C   . LYS   A 1 8   ? -5.87900  -8.40300  -8.47600  1.000 42.74437 ? 204 LYS   A C   1 
ATOM   20   O O   . LYS   A 1 8   ? -5.51700  -7.95100  -9.57100  1.000 36.83887 ? 204 LYS   A O   1 
ATOM   21   C CB  . LYS   A 1 8   ? -8.15800  -9.47200  -8.37200  1.000 51.06107 ? 204 LYS   A CB  1 
ATOM   22   C CG  . LYS   A 1 8   ? -8.98500  -10.67600 -8.81200  1.000 53.39506 ? 204 LYS   A CG  1 
ATOM   23   C CD  . LYS   A 1 8   ? -10.47300 -10.34000 -8.88100  1.000 66.93643 ? 204 LYS   A CD  1 
ATOM   24   C CE  . LYS   A 1 8   ? -11.29700 -11.51500 -9.39000  1.000 71.43545 ? 204 LYS   A CE  1 
ATOM   25   N NZ  . LYS   A 1 8   ? -11.11200 -11.73500 -10.85500 1.000 74.38903 ? 204 LYS   A NZ  1 
ATOM   26   N N   . SER   A 1 9   ? -5.60700  -7.79400  -7.32300  1.000 43.19652 ? 205 SER   A N   1 
ATOM   27   C CA  . SER   A 1 9   ? -4.77900  -6.59900  -7.29700  1.000 40.39981 ? 205 SER   A CA  1 
ATOM   28   C C   . SER   A 1 9   ? -3.37700  -6.90400  -7.80000  1.000 36.26489 ? 205 SER   A C   1 
ATOM   29   O O   . SER   A 1 9   ? -2.85600  -6.18700  -8.66300  1.000 34.64271 ? 205 SER   A O   1 
ATOM   30   C CB  . SER   A 1 9   ? -4.71600  -6.01700  -5.88900  1.000 46.36083 ? 205 SER   A CB  1 
ATOM   31   O OG  . SER   A 1 9   ? -3.93000  -4.84700  -5.88600  1.000 41.04925 ? 205 SER   A OG  1 
ATOM   32   N N   . LEU   A 1 10  ? -2.74400  -7.95400  -7.24900  1.000 30.99892 ? 206 LEU   A N   1 
ATOM   33   C CA  . LEU   A 1 10  ? -1.38500  -8.31500  -7.66100  1.000 30.79191 ? 206 LEU   A CA  1 
ATOM   34   C C   . LEU   A 1 10  ? -1.30600  -8.52700  -9.17100  1.000 28.35430 ? 206 LEU   A C   1 
ATOM   35   O O   . LEU   A 1 10  ? -0.37600  -8.03500  -9.82400  1.000 26.59470 ? 206 LEU   A O   1 
ATOM   36   C CB  . LEU   A 1 10  ? -0.91000  -9.56800  -6.90900  1.000 25.51082 ? 206 LEU   A CB  1 
ATOM   37   C CG  . LEU   A 1 10  ? 0.46600   -10.18100 -7.22600  1.000 30.28858 ? 206 LEU   A CG  1 
ATOM   38   C CD1 . LEU   A 1 10  ? 1.56800   -9.15000  -7.09100  1.000 32.55387 ? 206 LEU   A CD1 1 
ATOM   39   C CD2 . LEU   A 1 10  ? 0.75900   -11.36700 -6.32700  1.000 33.41947 ? 206 LEU   A CD2 1 
ATOM   40   N N   . ALA   A 1 11  ? -2.28400  -9.22900  -9.74500  1.000 26.44805 ? 207 ALA   A N   1 
ATOM   41   C CA  . ALA   A 1 11  ? -2.28100  -9.48400  -11.19200 1.000 26.33639 ? 207 ALA   A CA  1 
ATOM   42   C C   . ALA   A 1 11  ? -2.43200  -8.19100  -11.98300 1.000 27.49130 ? 207 ALA   A C   1 
ATOM   43   O O   . ALA   A 1 11  ? -1.73500  -7.97800  -12.99400 1.000 26.20384 ? 207 ALA   A O   1 
ATOM   44   C CB  . ALA   A 1 11  ? -3.39800  -10.45800 -11.55800 1.000 30.71545 ? 207 ALA   A CB  1 
ATOM   45   N N   . LYS   A 1 12  ? -3.35500  -7.32400  -11.55100 1.000 27.69163 ? 208 LYS   A N   1 
ATOM   46   C CA  . LYS   A 1 12  ? -3.54300  -6.04800  -12.23000 1.000 30.28035 ? 208 LYS   A CA  1 
ATOM   47   C C   . LYS   A 1 12  ? -2.27600  -5.20900  -12.16300 1.000 26.63495 ? 208 LYS   A C   1 
ATOM   48   O O   . LYS   A 1 12  ? -1.85700  -4.62200  -13.17000 1.000 27.87145 ? 208 LYS   A O   1 
ATOM   49   C CB  . LYS   A 1 12  ? -4.73000  -5.29200  -11.61000 1.000 33.46031 ? 208 LYS   A CB  1 
ATOM   50   C CG  . LYS   A 1 12  ? -5.14000  -4.04100  -12.39600 1.000 40.47430 ? 208 LYS   A CG  1 
ATOM   51   C CD  . LYS   A 1 12  ? -6.27600  -3.28800  -11.68900 1.000 46.23942 ? 208 LYS   A CD  1 
ATOM   52   C CE  . LYS   A 1 12  ? -7.55200  -3.29300  -12.52800 1.000 51.98030 ? 208 LYS   A CE  1 
ATOM   53   N NZ  . LYS   A 1 12  ? -8.28800  -1.99600  -12.49600 1.000 59.35225 ? 208 LYS   A NZ  1 
ATOM   54   N N   . ARG   A 1 13  ? -1.61300  -5.19000  -11.00100 1.000 26.46067 ? 209 ARG   A N   1 
ATOM   55   C CA  . ARG   A 1 13  ? -0.43800  -4.34600  -10.84700 1.000 24.25511 ? 209 ARG   A CA  1 
ATOM   56   C C   . ARG   A 1 13  ? 0.71000   -4.84200  -11.72800 1.000 21.48986 ? 209 ARG   A C   1 
ATOM   57   O O   . ARG   A 1 13  ? 1.44200   -4.04200  -12.31400 1.000 24.31543 ? 209 ARG   A O   1 
ATOM   58   C CB  . ARG   A 1 13  ? -0.02100  -4.29400  -9.37300  1.000 28.27703 ? 209 ARG   A CB  1 
ATOM   59   C CG  . ARG   A 1 13  ? -1.07300  -3.56300  -8.48800  1.000 30.32807 ? 209 ARG   A CG  1 
ATOM   60   C CD  . ARG   A 1 13  ? -0.75200  -3.74900  -7.01300  1.000 29.46081 ? 209 ARG   A CD  1 
ATOM   61   N NE  . ARG   A 1 13  ? 0.54700   -3.16700  -6.72200  1.000 33.46903 ? 209 ARG   A NE  1 
ATOM   62   C CZ  . ARG   A 1 13  ? 1.25300   -3.42000  -5.62800  1.000 30.49641 ? 209 ARG   A CZ  1 
ATOM   63   N NH1 . ARG   A 1 13  ? 0.80200   -4.24300  -4.69500  1.000 31.57579 ? 209 ARG   A NH1 1 
ATOM   64   N NH2 . ARG   A 1 13  ? 2.44200   -2.84400  -5.47800  1.000 38.43338 ? 209 ARG   A NH2 1 
ATOM   65   N N   . ILE   A 1 14  ? 0.86700   -6.16200  -11.82900 1.000 21.51254 ? 210 ILE   A N   1 
ATOM   66   C CA  . ILE   A 1 14  ? 1.91400   -6.70900  -12.70200 1.000 20.51821 ? 210 ILE   A CA  1 
ATOM   67   C C   . ILE   A 1 14  ? 1.60900   -6.42000  -14.17300 1.000 20.39419 ? 210 ILE   A C   1 
ATOM   68   O O   . ILE   A 1 14  ? 2.51000   -6.03600  -14.93900 1.000 19.62787 ? 210 ILE   A O   1 
ATOM   69   C CB  . ILE   A 1 14  ? 2.06500   -8.21400  -12.42700 1.000 20.25518 ? 210 ILE   A CB  1 
ATOM   70   C CG1 . ILE   A 1 14  ? 2.71000   -8.46700  -11.05400 1.000 22.56451 ? 210 ILE   A CG1 1 
ATOM   71   C CG2 . ILE   A 1 14  ? 2.95100   -8.90200  -13.51500 1.000 21.67214 ? 210 ILE   A CG2 1 
ATOM   72   C CD1 . ILE   A 1 14  ? 2.68800   -9.93900  -10.60600 1.000 22.84327 ? 210 ILE   A CD1 1 
ATOM   73   N N   . TYR   A 1 15  ? 0.33800   -6.57000  -14.58600 1.000 21.83448 ? 211 TYR   A N   1 
ATOM   74   C CA  . TYR   A 1 15  ? -0.05200  -6.30700  -15.97400 1.000 21.28977 ? 211 TYR   A CA  1 
ATOM   75   C C   . TYR   A 1 15  ? 0.15500   -4.83700  -16.32800 1.000 20.98853 ? 211 TYR   A C   1 
ATOM   76   O O   . TYR   A 1 15  ? 0.66700   -4.51500  -17.41400 1.000 21.54015 ? 211 TYR   A O   1 
ATOM   77   C CB  . TYR   A 1 15  ? -1.52200  -6.72300  -16.19700 1.000 21.39633 ? 211 TYR   A CB  1 
ATOM   78   C CG  . TYR   A 1 15  ? -2.04700  -6.56800  -17.61600 1.000 21.95438 ? 211 TYR   A CG  1 
ATOM   79   C CD1 . TYR   A 1 15  ? -1.23100  -6.77700  -18.72100 1.000 25.12404 ? 211 TYR   A CD1 1 
ATOM   80   C CD2 . TYR   A 1 15  ? -3.38100  -6.23100  -17.85600 1.000 28.56241 ? 211 TYR   A CD2 1 
ATOM   81   C CE1 . TYR   A 1 15  ? -1.70800  -6.64300  -20.01000 1.000 28.49689 ? 211 TYR   A CE1 1 
ATOM   82   C CE2 . TYR   A 1 15  ? -3.86900  -6.10600  -19.15900 1.000 29.59640 ? 211 TYR   A CE2 1 
ATOM   83   C CZ  . TYR   A 1 15  ? -3.02100  -6.31600  -20.22600 1.000 29.52607 ? 211 TYR   A CZ  1 
ATOM   84   O OH  . TYR   A 1 15  ? -3.45100  -6.18300  -21.53300 1.000 33.05633 ? 211 TYR   A OH  1 
ATOM   85   N N   . GLU   A 1 16  ? -0.23200  -3.92700  -15.41800 1.000 21.68169 ? 212 GLU   A N   1 
ATOM   86   C CA  . GLU   A 1 16  ? -0.02400  -2.51200  -15.69500 1.000 23.56294 ? 212 GLU   A CA  1 
ATOM   87   C C   . GLU   A 1 16  ? 1.46500   -2.18900  -15.78900 1.000 21.08651 ? 212 GLU   A C   1 
ATOM   88   O O   . GLU   A 1 16  ? 1.87800   -1.38900  -16.63500 1.000 24.21137 ? 212 GLU   A O   1 
ATOM   89   C CB  . GLU   A 1 16  ? -0.71800  -1.66600  -14.62400 1.000 27.23614 ? 212 GLU   A CB  1 
ATOM   90   C CG  . GLU   A 1 16  ? -2.23200  -1.70100  -14.83100 1.000 31.13430 ? 212 GLU   A CG  1 
ATOM   91   C CD  . GLU   A 1 16  ? -3.00100  -1.02900  -13.69600 1.000 49.28623 ? 212 GLU   A CD  1 
ATOM   92   O OE1 . GLU   A 1 16  ? -2.39400  -0.75000  -12.63500 1.000 41.70595 ? 212 GLU   A OE1 1 
ATOM   93   O OE2 . GLU   A 1 16  ? -4.22800  -0.83900  -13.84700 1.000 47.51860 ? 212 GLU   A OE2 1 
ATOM   94   N N   . ALA   A 1 17  ? 2.29100   -2.83500  -14.95400 1.000 22.47919 ? 213 ALA   A N   1 
ATOM   95   C CA  . ALA   A 1 17  ? 3.73900   -2.60300  -15.00900 1.000 20.56485 ? 213 ALA   A CA  1 
ATOM   96   C C   . ALA   A 1 17  ? 4.32800   -3.08200  -16.33600 1.000 21.90905 ? 213 ALA   A C   1 
ATOM   97   O O   . ALA   A 1 17  ? 5.22500   -2.45000  -16.89700 1.000 22.75545 ? 213 ALA   A O   1 
ATOM   98   C CB  . ALA   A 1 17  ? 4.43100   -3.31000  -13.85400 1.000 21.68436 ? 213 ALA   A CB  1 
ATOM   99   N N   . TYR   A 1 18  ? 3.81400   -4.19200  -16.84300 1.000 20.33676 ? 214 TYR   A N   1 
ATOM   100  C CA  . TYR   A 1 18  ? 4.23600   -4.69900  -18.14700 1.000 19.01111 ? 214 TYR   A CA  1 
ATOM   101  C C   . TYR   A 1 18  ? 3.85100   -3.73000  -19.26300 1.000 22.48776 ? 214 TYR   A C   1 
ATOM   102  O O   . TYR   A 1 18  ? 4.66200   -3.40300  -20.13800 1.000 21.53646 ? 214 TYR   A O   1 
ATOM   103  C CB  . TYR   A 1 18  ? 3.57400   -6.06100  -18.33200 1.000 19.47718 ? 214 TYR   A CB  1 
ATOM   104  C CG  . TYR   A 1 18  ? 3.65100   -6.71000  -19.68300 1.000 23.15662 ? 214 TYR   A CG  1 
ATOM   105  C CD1 . TYR   A 1 18  ? 4.53900   -7.75800  -19.90600 1.000 24.13694 ? 214 TYR   A CD1 1 
ATOM   106  C CD2 . TYR   A 1 18  ? 2.74600   -6.35900  -20.69900 1.000 22.48197 ? 214 TYR   A CD2 1 
ATOM   107  C CE1 . TYR   A 1 18  ? 4.54200   -8.42900  -21.15100 1.000 22.04048 ? 214 TYR   A CE1 1 
ATOM   108  C CE2 . TYR   A 1 18  ? 2.75400   -6.99800  -21.92200 1.000 24.80221 ? 214 TYR   A CE2 1 
ATOM   109  C CZ  . TYR   A 1 18  ? 3.66600   -8.02600  -22.14300 1.000 28.39524 ? 214 TYR   A CZ  1 
ATOM   110  O OH  . TYR   A 1 18  ? 3.65000   -8.68200  -23.35500 1.000 27.31246 ? 214 TYR   A OH  1 
ATOM   111  N N   . LEU   A 1 19  ? 2.59600   -3.25600  -19.24800 1.000 21.22614 ? 215 LEU   A N   1 
ATOM   112  C CA  . LEU   A 1 19  ? 2.17300   -2.34900  -20.30600 1.000 22.27048 ? 215 LEU   A CA  1 
ATOM   113  C C   . LEU   A 1 19  ? 2.93400   -1.03900  -20.25800 1.000 22.88791 ? 215 LEU   A C   1 
ATOM   114  O O   . LEU   A 1 19  ? 3.19100   -0.42300  -21.30200 1.000 27.89914 ? 215 LEU   A O   1 
ATOM   115  C CB  . LEU   A 1 19  ? 0.66400   -2.08800  -20.19900 1.000 22.74090 ? 215 LEU   A CB  1 
ATOM   116  C CG  . LEU   A 1 19  ? -0.23900  -3.29600  -20.43000 1.000 24.97379 ? 215 LEU   A CG  1 
ATOM   117  C CD1 . LEU   A 1 19  ? -1.70000  -2.92100  -20.09400 1.000 29.81494 ? 215 LEU   A CD1 1 
ATOM   118  C CD2 . LEU   A 1 19  ? -0.08000  -3.85800  -21.84900 1.000 28.12526 ? 215 LEU   A CD2 1 
ATOM   119  N N   . LYS   A 1 20  ? 3.32300   -0.60800  -19.06100 1.000 22.74673 ? 216 LYS   A N   1 
ATOM   120  C CA  . LYS   A 1 20  ? 4.05400   0.64800   -18.91500 1.000 24.40009 ? 216 LYS   A CA  1 
ATOM   121  C C   . LYS   A 1 20  ? 5.50300   0.55100   -19.39300 1.000 25.39835 ? 216 LYS   A C   1 
ATOM   122  O O   . LYS   A 1 20  ? 6.04200   1.51700   -19.95100 1.000 28.29914 ? 216 LYS   A O   1 
ATOM   123  C CB  . LYS   A 1 20  ? 3.98000   1.08700   -17.45000 1.000 26.07411 ? 216 LYS   A CB  1 
ATOM   124  C CG  . LYS   A 1 20  ? 4.93400   2.20500   -17.07100 1.000 33.43014 ? 216 LYS   A CG  1 
ATOM   125  C CD  . LYS   A 1 20  ? 4.72500   2.67100   -15.62800 1.000 37.74043 ? 216 LYS   A CD  1 
ATOM   126  C CE  . LYS   A 1 20  ? 5.52000   3.94100   -15.35900 1.000 51.08623 ? 216 LYS   A CE  1 
ATOM   127  N NZ  . LYS   A 1 20  ? 6.55600   3.71100   -14.31600 1.000 50.33623 ? 216 LYS   A NZ  1 
ATOM   128  N N   . ASN   A 1 21  ? 6.17000   -0.59000  -19.16700 1.000 22.38176 ? 217 ASN   A N   1 
ATOM   129  C CA  . ASN   A 1 21  ? 7.62100   -0.61100  -19.28100 1.000 19.16130 ? 217 ASN   A CA  1 
ATOM   130  C C   . ASN   A 1 21  ? 8.15900   -1.23100  -20.56200 1.000 22.92142 ? 217 ASN   A C   1 
ATOM   131  O O   . ASN   A 1 21  ? 9.34500   -1.02400  -20.87200 1.000 27.60049 ? 217 ASN   A O   1 
ATOM   132  C CB  . ASN   A 1 21  ? 8.22800   -1.36900  -18.10000 1.000 20.54549 ? 217 ASN   A CB  1 
ATOM   133  C CG  . ASN   A 1 21  ? 8.24800   -0.52200  -16.86700 1.000 24.71318 ? 217 ASN   A CG  1 
ATOM   134  O OD1 . ASN   A 1 21  ? 8.97400   0.47100   -16.81600 1.000 28.09603 ? 217 ASN   A OD1 1 
ATOM   135  N ND2 . ASN   A 1 21  ? 7.40900   -0.85700  -15.89200 1.000 24.32816 ? 217 ASN   A ND2 1 
ATOM   136  N N   . PHE   A 1 22  ? 7.37000   -2.00700  -21.28600 1.000 21.42387 ? 218 PHE   A N   1 
ATOM   137  C CA  . PHE   A 1 22  ? 7.85900   -2.64200  -22.50600 1.000 20.69243 ? 218 PHE   A CA  1 
ATOM   138  C C   . PHE   A 1 22  ? 7.35000   -1.88200  -23.72900 1.000 23.41619 ? 218 PHE   A C   1 
ATOM   139  O O   . PHE   A 1 22  ? 6.14700   -1.62500  -23.85100 1.000 24.44882 ? 218 PHE   A O   1 
ATOM   140  C CB  . PHE   A 1 22  ? 7.45300   -4.11400  -22.56800 1.000 21.69882 ? 218 PHE   A CB  1 
ATOM   141  C CG  . PHE   A 1 22  ? 8.09700   -4.92900  -21.49100 1.000 20.01613 ? 218 PHE   A CG  1 
ATOM   142  C CD1 . PHE   A 1 22  ? 9.47200   -5.15800  -21.49600 1.000 23.42617 ? 218 PHE   A CD1 1 
ATOM   143  C CD2 . PHE   A 1 22  ? 7.33400   -5.42000  -20.43100 1.000 20.84638 ? 218 PHE   A CD2 1 
ATOM   144  C CE1 . PHE   A 1 22  ? 10.07300  -5.88700  -20.46100 1.000 26.44208 ? 218 PHE   A CE1 1 
ATOM   145  C CE2 . PHE   A 1 22  ? 7.92400   -6.14000  -19.39200 1.000 23.13333 ? 218 PHE   A CE2 1 
ATOM   146  C CZ  . PHE   A 1 22  ? 9.30800   -6.36900  -19.41500 1.000 23.80266 ? 218 PHE   A CZ  1 
ATOM   147  N N   . ASN   A 1 23  ? 8.26500   -1.53400  -24.63700 1.000 21.27113 ? 219 ASN   A N   1 
ATOM   148  C CA  . ASN   A 1 23  ? 7.86000   -0.73200  -25.79900 1.000 21.35766 ? 219 ASN   A CA  1 
ATOM   149  C C   . ASN   A 1 23  ? 7.01700   -1.54000  -26.76600 1.000 22.61210 ? 219 ASN   A C   1 
ATOM   150  O O   . ASN   A 1 23  ? 6.21600   -0.98100  -27.52900 1.000 27.71711 ? 219 ASN   A O   1 
ATOM   151  C CB  . ASN   A 1 23  ? 9.08500   -0.15700  -26.52700 1.000 23.63105 ? 219 ASN   A CB  1 
ATOM   152  C CG  . ASN   A 1 23  ? 9.83300   -1.20500  -27.35800 1.000 26.37555 ? 219 ASN   A CG  1 
ATOM   153  O OD1 . ASN   A 1 23  ? 9.48200   -1.49600  -28.51500 1.000 26.38480 ? 219 ASN   A OD1 1 
ATOM   154  N ND2 . ASN   A 1 23  ? 10.86200  -1.78400  -26.76600 1.000 26.87526 ? 219 ASN   A ND2 1 
ATOM   155  N N   . MET   A 1 24  ? 7.22100   -2.85000  -26.77600 1.000 22.31285 ? 220 MET   A N   1 
ATOM   156  C CA  . MET   A 1 24  ? 6.54700   -3.78100  -27.65600 1.000 25.44742 ? 220 MET   A CA  1 
ATOM   157  C C   . MET   A 1 24  ? 5.80600   -4.79700  -26.81200 1.000 25.26080 ? 220 MET   A C   1 
ATOM   158  O O   . MET   A 1 24  ? 6.29600   -5.24000  -25.76500 1.000 26.32571 ? 220 MET   A O   1 
ATOM   159  C CB  . MET   A 1 24  ? 7.53200   -4.47400  -28.60200 1.000 27.53211 ? 220 MET   A CB  1 
ATOM   160  C CG  . MET   A 1 24  ? 6.86600   -5.26700  -29.68900 1.000 29.25672 ? 220 MET   A CG  1 
ATOM   161  S SD  . MET   A 1 24  ? 5.72200   -4.42800  -30.77200 1.000 29.08886 ? 220 MET   A SD  1 
ATOM   162  C CE  . MET   A 1 24  ? 6.79200   -3.22200  -31.56300 1.000 29.89603 ? 220 MET   A CE  1 
ATOM   163  N N   . ASN   A 1 25  ? 4.59800   -5.09400  -27.23400 1.000 25.76969 ? 221 ASN   A N   1 
ATOM   164  C CA  . ASN   A 1 25  ? 3.80800   -6.14000  -26.59800 1.000 26.34703 ? 221 ASN   A CA  1 
ATOM   165  C C   . ASN   A 1 25  ? 3.05700   -6.86200  -27.69700 1.000 29.47112 ? 221 ASN   A C   1 
ATOM   166  O O   . ASN   A 1 25  ? 3.17300   -6.52800  -28.87700 1.000 25.03334 ? 221 ASN   A O   1 
ATOM   167  C CB  . ASN   A 1 25  ? 2.84300   -5.59900  -25.53700 1.000 30.99785 ? 221 ASN   A CB  1 
ATOM   168  C CG  . ASN   A 1 25  ? 1.88000   -4.55300  -26.07100 1.000 30.77682 ? 221 ASN   A CG  1 
ATOM   169  O OD1 . ASN   A 1 25  ? 1.19600   -4.73200  -27.08500 1.000 34.20620 ? 221 ASN   A OD1 1 
ATOM   170  N ND2 . ASN   A 1 25  ? 1.79000   -3.45100  -25.34800 1.000 35.20870 ? 221 ASN   A ND2 1 
ATOM   171  N N   . LYS   A 1 26  ? 2.25600   -7.84500  -27.30700 1.000 23.85789 ? 222 LYS   A N   1 
ATOM   172  C CA  . LYS   A 1 26  ? 1.73000   -8.75400  -28.31000 1.000 22.37325 ? 222 LYS   A CA  1 
ATOM   173  C C   . LYS   A 1 26  ? 0.62700   -8.10400  -29.13800 1.000 25.63072 ? 222 LYS   A C   1 
ATOM   174  O O   . LYS   A 1 26  ? 0.55700   -8.31400  -30.35900 1.000 25.01709 ? 222 LYS   A O   1 
ATOM   175  C CB  . LYS   A 1 26  ? 1.23000   -10.02800 -27.62900 1.000 25.98491 ? 222 LYS   A CB  1 
ATOM   176  C CG  . LYS   A 1 26  ? 0.98700   -11.13600 -28.58200 1.000 25.48650 ? 222 LYS   A CG  1 
ATOM   177  C CD  . LYS   A 1 26  ? 0.97100   -12.44900 -27.89100 1.000 25.30662 ? 222 LYS   A CD  1 
ATOM   178  C CE  . LYS   A 1 26  ? 0.63300   -13.55500 -28.85200 1.000 26.67036 ? 222 LYS   A CE  1 
ATOM   179  N NZ  . LYS   A 1 26  ? 0.63000   -14.84100 -28.13100 1.000 24.76323 ? 222 LYS   A NZ  1 
ATOM   180  N N   . VAL   A 1 27  ? -0.24200  -7.31700  -28.49600 1.000 24.18132 ? 223 VAL   A N   1 
ATOM   181  C CA  . VAL   A 1 27  ? -1.28200  -6.60600  -29.24200 1.000 29.69225 ? 223 VAL   A CA  1 
ATOM   182  C C   . VAL   A 1 27  ? -0.65900  -5.67300  -30.27600 1.000 27.58105 ? 223 VAL   A C   1 
ATOM   183  O O   . VAL   A 1 27  ? -1.03400  -5.71500  -31.45500 1.000 29.31587 ? 223 VAL   A O   1 
ATOM   184  C CB  . VAL   A 1 27  ? -2.21300  -5.83800  -28.28400 1.000 31.52409 ? 223 VAL   A CB  1 
ATOM   185  C CG1 . VAL   A 1 27  ? -2.85500  -4.66000  -29.00700 1.000 43.17623 ? 223 VAL   A CG1 1 
ATOM   186  C CG2 . VAL   A 1 27  ? -3.28100  -6.74400  -27.76300 1.000 35.73035 ? 223 VAL   A CG2 1 
ATOM   187  N N   . LYS   A 1 28  ? 0.30100   -4.82300  -29.84300 1.000 26.13712 ? 224 LYS   A N   1 
ATOM   188  C CA  . LYS   A 1 28  ? 1.00100   -3.90000  -30.74700 1.000 24.45038 ? 224 LYS   A CA  1 
ATOM   189  C C   . LYS   A 1 28  ? 1.67400   -4.67200  -31.87800 1.000 27.76457 ? 224 LYS   A C   1 
ATOM   190  O O   . LYS   A 1 28  ? 1.58300   -4.29400  -33.05600 1.000 27.25264 ? 224 LYS   A O   1 
ATOM   191  C CB  . LYS   A 1 28  ? 2.05200   -3.07400  -29.99100 1.000 31.20627 ? 224 LYS   A CB  1 
ATOM   192  C CG  . LYS   A 1 28  ? 1.49400   -1.91000  -29.15800 1.000 38.32623 ? 224 LYS   A CG  1 
ATOM   193  C CD  . LYS   A 1 28  ? 2.57000   -1.21400  -28.32900 1.000 39.94623 ? 224 LYS   A CD  1 
ATOM   194  C CE  . LYS   A 1 28  ? 3.35500   -0.19200  -29.15200 1.000 44.95623 ? 224 LYS   A CE  1 
ATOM   195  N NZ  . LYS   A 1 28  ? 4.28000   0.65700   -28.31700 1.000 39.99623 ? 224 LYS   A NZ  1 
ATOM   196  N N   . ALA   A 1 29  ? 2.32100   -5.77900  -31.54200 1.000 21.12247 ? 225 ALA   A N   1 
ATOM   197  C CA  . ALA   A 1 29  ? 3.05800   -6.52000  -32.56600 1.000 20.98087 ? 225 ALA   A CA  1 
ATOM   198  C C   . ALA   A 1 29  ? 2.11800   -7.11800  -33.59700 1.000 27.23790 ? 225 ALA   A C   1 
ATOM   199  O O   . ALA   A 1 29  ? 2.42400   -7.13000  -34.79700 1.000 25.95725 ? 225 ALA   A O   1 
ATOM   200  C CB  . ALA   A 1 29  ? 3.88200   -7.63500  -31.91000 1.000 20.58032 ? 225 ALA   A CB  1 
ATOM   201  N N   . ARG   A 1 30  ? 0.98700   -7.64600  -33.14500 1.000 24.32711 ? 226 ARG   A N   1 
ATOM   202  C CA  . ARG   A 1 30  ? 0.00900   -8.21700  -34.07300 1.000 31.92050 ? 226 ARG   A CA  1 
ATOM   203  C C   . ARG   A 1 30  ? -0.58000  -7.16100  -35.00500 1.000 29.70732 ? 226 ARG   A C   1 
ATOM   204  O O   . ARG   A 1 30  ? -0.79000  -7.42600  -36.19200 1.000 37.93842 ? 226 ARG   A O   1 
ATOM   205  C CB  . ARG   A 1 30  ? -1.10600  -8.92900  -33.29300 1.000 31.91202 ? 226 ARG   A CB  1 
ATOM   206  C CG  . ARG   A 1 30  ? -0.65200  -10.19800 -32.58700 1.000 38.77453 ? 226 ARG   A CG  1 
ATOM   207  C CD  . ARG   A 1 30  ? 0.17600   -11.08700 -33.49700 1.000 50.46623 ? 226 ARG   A CD  1 
ATOM   208  N NE  . ARG   A 1 30  ? 1.23100   -11.79200 -32.77100 1.000 53.56623 ? 226 ARG   A NE  1 
ATOM   209  C CZ  . ARG   A 1 30  ? 2.21600   -12.46400 -33.35500 1.000 53.74623 ? 226 ARG   A CZ  1 
ATOM   210  N NH1 . ARG   A 1 30  ? 3.14200   -13.09200 -32.65100 1.000 36.57378 ? 226 ARG   A NH1 1 
ATOM   211  N NH2 . ARG   A 1 30  ? 2.28100   -12.49800 -34.68200 1.000 56.34623 ? 226 ARG   A NH2 1 
ATOM   212  N N   . VAL   A 1 31  ? -0.86500  -5.97000  -34.48700 1.000 29.61463 ? 227 VAL   A N   1 
ATOM   213  C CA  . VAL   A 1 31  ? -1.37400  -4.88500  -35.32800 1.000 33.99275 ? 227 VAL   A CA  1 
ATOM   214  C C   . VAL   A 1 31  ? -0.37200  -4.54000  -36.42700 1.000 36.29369 ? 227 VAL   A C   1 
ATOM   215  O O   . VAL   A 1 31  ? -0.74700  -4.29800  -37.58200 1.000 38.23697 ? 227 VAL   A O   1 
ATOM   216  C CB  . VAL   A 1 31  ? -1.70500  -3.66200  -34.45200 1.000 36.73623 ? 227 VAL   A CB  1 
ATOM   217  C CG1 . VAL   A 1 31  ? -1.76300  -2.38000  -35.28200 1.000 39.85623 ? 227 VAL   A CG1 1 
ATOM   218  C CG2 . VAL   A 1 31  ? -3.00500  -3.89400  -33.68500 1.000 36.14477 ? 227 VAL   A CG2 1 
ATOM   219  N N   . ILE   A 1 32  ? 0.92100   -4.53300  -36.09500 1.000 29.19806 ? 228 ILE   A N   1 
ATOM   220  C CA  . ILE   A 1 32  ? 1.94600   -4.24500  -37.09500 1.000 31.39023 ? 228 ILE   A CA  1 
ATOM   221  C C   . ILE   A 1 32  ? 2.07200   -5.39600  -38.08300 1.000 33.81197 ? 228 ILE   A C   1 
ATOM   222  O O   . ILE   A 1 32  ? 2.14500   -5.18800  -39.30200 1.000 39.26066 ? 228 ILE   A O   1 
ATOM   223  C CB  . ILE   A 1 32  ? 3.29600   -3.96100  -36.40600 1.000 25.03769 ? 228 ILE   A CB  1 
ATOM   224  C CG1 . ILE   A 1 32  ? 3.21700   -2.65200  -35.62500 1.000 29.92213 ? 228 ILE   A CG1 1 
ATOM   225  C CG2 . ILE   A 1 32  ? 4.40600   -3.93000  -37.46500 1.000 31.44093 ? 228 ILE   A CG2 1 
ATOM   226  C CD1 . ILE   A 1 32  ? 4.40100   -2.41200  -34.66600 1.000 30.25922 ? 228 ILE   A CD1 1 
ATOM   227  N N   . LEU   A 1 33  ? 2.13200   -6.62200  -37.57500 1.000 31.09285 ? 229 LEU   A N   1 
ATOM   228  C CA  . LEU   A 1 33  ? 2.29500   -7.80900  -38.40400 1.000 35.14397 ? 229 LEU   A CA  1 
ATOM   229  C C   . LEU   A 1 33  ? 1.01500   -8.13100  -39.18400 1.000 43.11284 ? 229 LEU   A C   1 
ATOM   230  O O   . LEU   A 1 33  ? 0.75000   -9.30200  -39.48100 1.000 57.95623 ? 229 LEU   A O   1 
ATOM   231  C CB  . LEU   A 1 33  ? 2.70400   -9.01300  -37.54900 1.000 35.17464 ? 229 LEU   A CB  1 
ATOM   232  C CG  . LEU   A 1 33  ? 4.11200   -9.05700  -36.93300 1.000 30.74915 ? 229 LEU   A CG  1 
ATOM   233  C CD1 . LEU   A 1 33  ? 4.32600   -10.18300 -35.93800 1.000 31.21208 ? 229 LEU   A CD1 1 
ATOM   234  C CD2 . LEU   A 1 33  ? 5.18900   -9.10300  -38.03500 1.000 35.21942 ? 229 LEU   A CD2 1 
ATOM   235  N N   . SER   A 1 34  ? 0.22700   -7.11900  -39.53100 1.000 46.15644 ? 230 SER   A N   1 
ATOM   236  C CA  . SER   A 1 34  ? -0.95500  -7.31000  -40.37300 1.000 50.31111 ? 230 SER   A CA  1 
ATOM   237  C C   . SER   A 1 34  ? -1.18500  -6.04200  -41.19500 1.000 58.50623 ? 230 SER   A C   1 
ATOM   238  O O   . SER   A 1 34  ? -0.26200  -5.25400  -41.42600 1.000 54.99499 ? 230 SER   A O   1 
ATOM   239  C CB  . SER   A 1 34  ? -2.18000  -7.66100  -39.51800 1.000 47.41311 ? 230 SER   A CB  1 
ATOM   240  O OG  . SER   A 1 34  ? -2.72800  -6.48100  -38.94800 1.000 48.41680 ? 230 SER   A OG  1 
ATOM   241  N N   . GLY   A 1 35  ? -2.42600  -5.83900  -41.62800 1.000 60.60920 ? 231 GLY   A N   1 
ATOM   242  C CA  . GLY   A 1 35  ? -2.77700  -4.68200  -42.43500 1.000 71.11623 ? 231 GLY   A CA  1 
ATOM   243  C C   . GLY   A 1 35  ? -2.61200  -3.35400  -41.72200 1.000 68.88716 ? 231 GLY   A C   1 
ATOM   244  O O   . GLY   A 1 35  ? -3.55500  -2.84100  -41.11700 1.000 70.17649 ? 231 GLY   A O   1 
ATOM   245  N N   . PRO   A 1 41  ? 3.79200   -0.16200  -42.37000 1.000 52.32623 ? 237 PRO   A N   1 
ATOM   246  C CA  . PRO   A 1 41  ? 4.40700   -1.33300  -42.99600 1.000 47.96623 ? 237 PRO   A CA  1 
ATOM   247  C C   . PRO   A 1 41  ? 5.90900   -1.47200  -42.73200 1.000 39.96960 ? 237 PRO   A C   1 
ATOM   248  O O   . PRO   A 1 41  ? 6.69600   -0.71300  -43.30300 1.000 38.69049 ? 237 PRO   A O   1 
ATOM   249  C CB  . PRO   A 1 41  ? 4.12600   -1.07900  -44.48300 1.000 49.44718 ? 237 PRO   A CB  1 
ATOM   250  C CG  . PRO   A 1 41  ? 3.90400   0.50500   -44.55300 1.000 56.09623 ? 237 PRO   A CG  1 
ATOM   251  C CD  . PRO   A 1 41  ? 4.20900   1.00500   -43.14900 1.000 48.45418 ? 237 PRO   A CD  1 
ATOM   252  N N   . PRO   A 1 42  ? 6.30100   -2.44200  -41.89800 1.000 33.78485 ? 238 PRO   A N   1 
ATOM   253  C CA  . PRO   A 1 42  ? 7.72400   -2.58500  -41.57000 1.000 30.38039 ? 238 PRO   A CA  1 
ATOM   254  C C   . PRO   A 1 42  ? 8.54300   -2.88900  -42.81000 1.000 28.59719 ? 238 PRO   A C   1 
ATOM   255  O O   . PRO   A 1 42  ? 8.09700   -3.59700  -43.71500 1.000 31.84681 ? 238 PRO   A O   1 
ATOM   256  C CB  . PRO   A 1 42  ? 7.76500   -3.76600  -40.59200 1.000 26.03909 ? 238 PRO   A CB  1 
ATOM   257  C CG  . PRO   A 1 42  ? 6.44400   -4.33800  -40.54100 1.000 35.02723 ? 238 PRO   A CG  1 
ATOM   258  C CD  . PRO   A 1 42  ? 5.48800   -3.55500  -41.39100 1.000 29.33355 ? 238 PRO   A CD  1 
ATOM   259  N N   . PHE   A 1 43  ? 9.77200   -2.39300  -42.81300 1.000 25.65658 ? 239 PHE   A N   1 
ATOM   260  C CA  . PHE   A 1 43  ? 10.67300  -2.64800  -43.92400 1.000 29.34707 ? 239 PHE   A CA  1 
ATOM   261  C C   . PHE   A 1 43  ? 11.22700  -4.07100  -43.80600 1.000 25.79789 ? 239 PHE   A C   1 
ATOM   262  O O   . PHE   A 1 43  ? 11.71900  -4.47100  -42.74400 1.000 26.22096 ? 239 PHE   A O   1 
ATOM   263  C CB  . PHE   A 1 43  ? 11.79000  -1.61400  -43.94200 1.000 27.73729 ? 239 PHE   A CB  1 
ATOM   264  C CG  . PHE   A 1 43  ? 12.78600  -1.84400  -45.01900 1.000 32.39019 ? 239 PHE   A CG  1 
ATOM   265  C CD1 . PHE   A 1 43  ? 12.52500  -1.40800  -46.30300 1.000 32.92963 ? 239 PHE   A CD1 1 
ATOM   266  C CD2 . PHE   A 1 43  ? 13.98200  -2.48500  -44.75500 1.000 31.04905 ? 239 PHE   A CD2 1 
ATOM   267  C CE1 . PHE   A 1 43  ? 13.44900  -1.62200  -47.30700 1.000 38.52623 ? 239 PHE   A CE1 1 
ATOM   268  C CE2 . PHE   A 1 43  ? 14.89300  -2.69300  -45.75700 1.000 34.99363 ? 239 PHE   A CE2 1 
ATOM   269  C CZ  . PHE   A 1 43  ? 14.62500  -2.25800  -47.02600 1.000 33.93362 ? 239 PHE   A CZ  1 
ATOM   270  N N   . VAL   A 1 44  ? 11.08600  -4.85400  -44.87200 1.000 24.54079 ? 240 VAL   A N   1 
ATOM   271  C CA  . VAL   A 1 44  ? 11.40200  -6.28000  -44.82600 1.000 23.46025 ? 240 VAL   A CA  1 
ATOM   272  C C   . VAL   A 1 44  ? 12.85800  -6.49600  -45.22400 1.000 29.86864 ? 240 VAL   A C   1 
ATOM   273  O O   . VAL   A 1 44  ? 13.29500  -6.07700  -46.30700 1.000 27.65201 ? 240 VAL   A O   1 
ATOM   274  C CB  . VAL   A 1 44  ? 10.45500  -7.10100  -45.71700 1.000 28.61637 ? 240 VAL   A CB  1 
ATOM   275  C CG1 . VAL   A 1 44  ? 10.90700  -8.55300  -45.77400 1.000 30.20384 ? 240 VAL   A CG1 1 
ATOM   276  C CG2 . VAL   A 1 44  ? 9.00500   -7.02900  -45.19600 1.000 29.28762 ? 240 VAL   A CG2 1 
ATOM   277  N N   . ILE   A 1 45  ? 13.59500  -7.17000  -44.34400 1.000 23.89774 ? 241 ILE   A N   1 
ATOM   278  C CA  . ILE   A 1 45  ? 14.99100  -7.54700  -44.55500 1.000 24.65113 ? 241 ILE   A CA  1 
ATOM   279  C C   . ILE   A 1 45  ? 15.00000  -9.03100  -44.89900 1.000 25.47755 ? 241 ILE   A C   1 
ATOM   280  O O   . ILE   A 1 45  ? 14.76300  -9.89400  -44.04100 1.000 24.42227 ? 241 ILE   A O   1 
ATOM   281  C CB  . ILE   A 1 45  ? 15.84400  -7.25000  -43.31500 1.000 24.08742 ? 241 ILE   A CB  1 
ATOM   282  C CG1 . ILE   A 1 45  ? 15.81200  -5.76200  -42.93700 1.000 22.94303 ? 241 ILE   A CG1 1 
ATOM   283  C CG2 . ILE   A 1 45  ? 17.27300  -7.75100  -43.50600 1.000 27.09575 ? 241 ILE   A CG2 1 
ATOM   284  C CD1 . ILE   A 1 45  ? 16.26700  -5.47100  -41.49000 1.000 26.76793 ? 241 ILE   A CD1 1 
ATOM   285  N N   . HIS   A 1 46  ? 15.26300  -9.34700  -46.16800 1.000 27.69824 ? 242 HIS   A N   1 
ATOM   286  C CA  . HIS   A 1 46  ? 15.19300  -10.72600 -46.62000 1.000 28.33145 ? 242 HIS   A CA  1 
ATOM   287  C C   . HIS   A 1 46  ? 16.42200  -11.11800 -47.41900 1.000 26.81184 ? 242 HIS   A C   1 
ATOM   288  O O   . HIS   A 1 46  ? 16.54700  -12.29500 -47.79000 1.000 28.93564 ? 242 HIS   A O   1 
ATOM   289  C CB  . HIS   A 1 46  ? 13.92900  -10.97000 -47.45500 1.000 29.78808 ? 242 HIS   A CB  1 
ATOM   290  C CG  . HIS   A 1 46  ? 13.88100  -10.16300 -48.71600 1.000 32.92976 ? 242 HIS   A CG  1 
ATOM   291  N ND1 . HIS   A 1 46  ? 14.39200  -10.62300 -49.91400 1.000 31.92099 ? 242 HIS   A ND1 1 
ATOM   292  C CD2 . HIS   A 1 46  ? 13.40100  -8.92000  -48.96300 1.000 32.32549 ? 242 HIS   A CD2 1 
ATOM   293  C CE1 . HIS   A 1 46  ? 14.21800  -9.70300  -50.84600 1.000 33.27663 ? 242 HIS   A CE1 1 
ATOM   294  N NE2 . HIS   A 1 46  ? 13.62600  -8.65700  -50.29800 1.000 35.00453 ? 242 HIS   A NE2 1 
ATOM   295  N N   . ASP   A 1 47  ? 17.33200  -10.18400 -47.66600 1.000 27.85789 ? 243 ASP   A N   1 
ATOM   296  C CA  . ASP   A 1 47  ? 18.55900  -10.49500 -48.38800 1.000 29.46548 ? 243 ASP   A CA  1 
ATOM   297  C C   . ASP   A 1 47  ? 19.57700  -9.40400  -48.10300 1.000 29.37082 ? 243 ASP   A C   1 
ATOM   298  O O   . ASP   A 1 47  ? 19.31100  -8.44100  -47.37300 1.000 27.69556 ? 243 ASP   A O   1 
ATOM   299  C CB  . ASP   A 1 47  ? 18.29000  -10.66300 -49.89000 1.000 30.09041 ? 243 ASP   A CB  1 
ATOM   300  C CG  . ASP   A 1 47  ? 17.76300  -9.40200  -50.56400 1.000 33.16094 ? 243 ASP   A CG  1 
ATOM   301  O OD1 . ASP   A 1 47  ? 17.64500  -8.32200  -49.94800 1.000 29.62593 ? 243 ASP   A OD1 1 
ATOM   302  O OD2 . ASP   A 1 47  ? 17.47400  -9.50500  -51.77400 1.000 36.53278 ? 243 ASP   A OD2 1 
ATOM   303  N N   . MET   A 1 48  ? 20.76600  -9.55500  -48.68600 1.000 30.68058 ? 244 MET   A N   1 
ATOM   304  C CA  . MET   A 1 48  ? 21.81200  -8.59000  -48.39800 1.000 25.90051 ? 244 MET   A CA  1 
ATOM   305  C C   . MET   A 1 48  ? 21.43900  -7.18900  -48.87300 1.000 27.14726 ? 244 MET   A C   1 
ATOM   306  O O   . MET   A 1 48  ? 21.79300  -6.19500  -48.22300 1.000 27.07189 ? 244 MET   A O   1 
ATOM   307  C CB  . MET   A 1 48  ? 23.13100  -9.03600  -49.05100 1.000 28.43885 ? 244 MET   A CB  1 
ATOM   308  C CG  . MET   A 1 48  ? 24.02900  -9.98200  -48.24200 1.000 36.82583 ? 244 MET   A CG  1 
ATOM   309  S SD  . MET   A 1 48  ? 24.05600  -9.85800  -46.42100 1.000 34.61991 ? 244 MET   A SD  1 
ATOM   310  C CE  . MET   A 1 48  ? 24.37600  -11.57100 -45.99200 1.000 32.90116 ? 244 MET   A CE  1 
ATOM   311  N N   . GLU   A 1 49  ? 20.78500  -7.07200  -50.04600 1.000 26.94644 ? 245 GLU   A N   1 
ATOM   312  C CA  . GLU   A 1 49  ? 20.42200  -5.74900  -50.53800 1.000 29.91663 ? 245 GLU   A CA  1 
ATOM   313  C C   . GLU   A 1 49  ? 19.53200  -5.02600  -49.53300 1.000 29.68588 ? 245 GLU   A C   1 
ATOM   314  O O   . GLU   A 1 49  ? 19.77000  -3.86200  -49.20300 1.000 27.19103 ? 245 GLU   A O   1 
ATOM   315  C CB  . GLU   A 1 49  ? 19.70800  -5.81900  -51.90300 1.000 30.28742 ? 245 GLU   A CB  1 
ATOM   316  C CG  . GLU   A 1 49  ? 19.46100  -4.39700  -52.46200 1.000 33.87238 ? 245 GLU   A CG  1 
ATOM   317  C CD  . GLU   A 1 49  ? 18.48100  -4.30000  -53.64500 1.000 36.62457 ? 245 GLU   A CD  1 
ATOM   318  O OE1 . GLU   A 1 49  ? 17.60900  -5.17100  -53.81300 1.000 35.91992 ? 245 GLU   A OE1 1 
ATOM   319  O OE2 . GLU   A 1 49  ? 18.57900  -3.31200  -54.40600 1.000 41.53261 ? 245 GLU   A OE2 1 
ATOM   320  N N   . THR   A 1 50  ? 18.49100  -5.70000  -49.05400 1.000 29.79631 ? 246 THR   A N   1 
ATOM   321  C CA  . THR   A 1 50  ? 17.58000  -5.02200  -48.14200 1.000 24.51622 ? 246 THR   A CA  1 
ATOM   322  C C   . THR   A 1 50  ? 18.19900  -4.86000  -46.76000 1.000 28.35001 ? 246 THR   A C   1 
ATOM   323  O O   . THR   A 1 50  ? 17.89000  -3.88600  -46.06800 1.000 27.78670 ? 246 THR   A O   1 
ATOM   324  C CB  . THR   A 1 50  ? 16.25100  -5.76500  -48.04100 1.000 25.67045 ? 246 THR   A CB  1 
ATOM   325  O OG1 . THR   A 1 50  ? 16.47400  -7.15000  -47.74800 1.000 26.96678 ? 246 THR   A OG1 1 
ATOM   326  C CG2 . THR   A 1 50  ? 15.45600  -5.63000  -49.34200 1.000 27.23358 ? 246 THR   A CG2 1 
ATOM   327  N N   . LEU   A 1 51  ? 19.08000  -5.77100  -46.33800 1.000 27.39364 ? 247 LEU   A N   1 
ATOM   328  C CA  . LEU   A 1 51  ? 19.80600  -5.50700  -45.09700 1.000 27.47358 ? 247 LEU   A CA  1 
ATOM   329  C C   . LEU   A 1 51  ? 20.56900  -4.19300  -45.18600 1.000 32.19460 ? 247 LEU   A C   1 
ATOM   330  O O   . LEU   A 1 51  ? 20.47800  -3.35700  -44.27800 1.000 29.26000 ? 247 LEU   A O   1 
ATOM   331  C CB  . LEU   A 1 51  ? 20.75400  -6.65100  -44.74100 1.000 27.41672 ? 247 LEU   A CB  1 
ATOM   332  C CG  . LEU   A 1 51  ? 21.68300  -6.36700  -43.55400 1.000 33.02564 ? 247 LEU   A CG  1 
ATOM   333  C CD1 . LEU   A 1 51  ? 20.92000  -6.37000  -42.21400 1.000 28.42132 ? 247 LEU   A CD1 1 
ATOM   334  C CD2 . LEU   A 1 51  ? 22.83800  -7.35000  -43.50400 1.000 32.49552 ? 247 LEU   A CD2 1 
ATOM   335  N N   . CYS   A 1 52  ? 21.30000  -3.96900  -46.29800 1.000 29.15912 ? 248 CYS   A N   1 
ATOM   336  C CA  . CYS   A 1 52  ? 22.06000  -2.72800  -46.41900 1.000 30.94479 ? 248 CYS   A CA  1 
ATOM   337  C C   . CYS   A 1 52  ? 21.12400  -1.52600  -46.48600 1.000 31.12661 ? 248 CYS   A C   1 
ATOM   338  O O   . CYS   A 1 52  ? 21.42800  -0.46200  -45.93700 1.000 33.42101 ? 248 CYS   A O   1 
ATOM   339  C CB  . CYS   A 1 52  ? 22.98200  -2.77500  -47.64700 1.000 28.34815 ? 248 CYS   A CB  1 
ATOM   340  S SG  . CYS   A 1 52  ? 24.28000  -4.03700  -47.53000 1.000 35.71611 ? 248 CYS   A SG  1 
ATOM   341  N N   . MET   A 1 53  ? 19.97000  -1.68500  -47.13400 1.000 27.42039 ? 249 MET   A N   1 
ATOM   342  C CA  . MET   A 1 53  ? 19.00500  -0.59500  -47.21200 1.000 30.54009 ? 249 MET   A CA  1 
ATOM   343  C C   . MET   A 1 53  ? 18.46500  -0.25300  -45.82900 1.000 33.14834 ? 249 MET   A C   1 
ATOM   344  O O   . MET   A 1 53  ? 18.40800  0.92300   -45.43900 1.000 32.67362 ? 249 MET   A O   1 
ATOM   345  C CB  . MET   A 1 53  ? 17.86300  -1.00100  -48.13000 1.000 29.87055 ? 249 MET   A CB  1 
ATOM   346  C CG  . MET   A 1 53  ? 18.13100  -0.79300  -49.60800 1.000 32.46710 ? 249 MET   A CG  1 
ATOM   347  S SD  . MET   A 1 53  ? 16.81700  -1.58300  -50.55200 1.000 44.08632 ? 249 MET   A SD  1 
ATOM   348  C CE  . MET   A 1 53  ? 15.41000  -0.52200  -50.18600 1.000 44.45470 ? 249 MET   A CE  1 
ATOM   349  N N   . ALA   A 1 54  ? 18.05700  -1.28300  -45.07600 1.000 32.33644 ? 250 ALA   A N   1 
ATOM   350  C CA  . ALA   A 1 54  ? 17.53400  -1.05400  -43.73200 1.000 34.16517 ? 250 ALA   A CA  1 
ATOM   351  C C   . ALA   A 1 54  ? 18.56200  -0.38200  -42.84600 1.000 34.26784 ? 250 ALA   A C   1 
ATOM   352  O O   . ALA   A 1 54  ? 18.21800  0.49900   -42.04800 1.000 36.04128 ? 250 ALA   A O   1 
ATOM   353  C CB  . ALA   A 1 54  ? 17.06800  -2.37000  -43.10300 1.000 32.50013 ? 250 ALA   A CB  1 
ATOM   354  N N   . GLU   A 1 55  ? 19.83200  -0.78500  -42.95200 1.000 29.10845 ? 251 GLU   A N   1 
ATOM   355  C CA  . GLU   A 1 55  ? 20.86900  -0.15200  -42.14900 1.000 35.73410 ? 251 GLU   A CA  1 
ATOM   356  C C   . GLU   A 1 55  ? 20.97500  1.34000   -42.44100 1.000 38.57639 ? 251 GLU   A C   1 
ATOM   357  O O   . GLU   A 1 55  ? 21.11100  2.14400   -41.51300 1.000 40.92679 ? 251 GLU   A O   1 
ATOM   358  C CB  . GLU   A 1 55  ? 22.22400  -0.83500  -42.36400 1.000 34.15053 ? 251 GLU   A CB  1 
ATOM   359  C CG  . GLU   A 1 55  ? 22.27900  -2.27400  -41.89300 1.000 36.04567 ? 251 GLU   A CG  1 
ATOM   360  C CD  . GLU   A 1 55  ? 23.57000  -2.95600  -42.30200 1.000 40.66623 ? 251 GLU   A CD  1 
ATOM   361  O OE1 . GLU   A 1 55  ? 24.27000  -3.50000  -41.42400 1.000 41.13607 ? 251 GLU   A OE1 1 
ATOM   362  O OE2 . GLU   A 1 55  ? 23.90500  -2.91800  -43.50200 1.000 39.35924 ? 251 GLU   A OE2 1 
ATOM   363  N N   . LYS   A 1 56  ? 20.92300  1.73100   -43.72100 1.000 36.95429 ? 252 LYS   A N   1 
ATOM   364  C CA  . LYS   A 1 56  ? 21.01600  3.15100   -44.07000 1.000 37.41054 ? 252 LYS   A CA  1 
ATOM   365  C C   . LYS   A 1 56  ? 19.82500  3.94900   -43.54700 1.000 40.23463 ? 252 LYS   A C   1 
ATOM   366  O O   . LYS   A 1 56  ? 19.98300  5.11400   -43.16000 1.000 43.47406 ? 252 LYS   A O   1 
ATOM   367  C CB  . LYS   A 1 56  ? 21.13700  3.31900   -45.59000 1.000 40.76445 ? 252 LYS   A CB  1 
ATOM   368  C CG  . LYS   A 1 56  ? 22.42600  2.73900   -46.19100 1.000 43.88882 ? 252 LYS   A CG  1 
ATOM   369  C CD  . LYS   A 1 56  ? 22.62000  3.14400   -47.66000 1.000 47.62959 ? 252 LYS   A CD  1 
ATOM   370  C CE  . LYS   A 1 56  ? 21.61200  2.44200   -48.58100 1.000 52.63623 ? 252 LYS   A CE  1 
ATOM   371  N NZ  . LYS   A 1 56  ? 22.05100  1.08900   -49.07600 1.000 49.13623 ? 252 LYS   A NZ  1 
ATOM   372  N N   . THR   A 1 57  ? 18.63800  3.35000   -43.50800 1.000 39.24846 ? 253 THR   A N   1 
ATOM   373  C CA  . THR   A 1 57  ? 17.47200  4.06700   -42.99500 1.000 41.74033 ? 253 THR   A CA  1 
ATOM   374  C C   . THR   A 1 57  ? 17.34200  3.96200   -41.48100 1.000 42.02031 ? 253 THR   A C   1 
ATOM   375  O O   . THR   A 1 57  ? 17.05600  4.96100   -40.81100 1.000 43.24623 ? 253 THR   A O   1 
ATOM   376  C CB  . THR   A 1 57  ? 16.19100  3.54300   -43.64900 1.000 48.56623 ? 253 THR   A CB  1 
ATOM   377  O OG1 . THR   A 1 57  ? 16.23700  3.79400   -45.06000 1.000 51.19623 ? 253 THR   A OG1 1 
ATOM   378  C CG2 . THR   A 1 57  ? 14.97200  4.23800   -43.05600 1.000 46.51014 ? 253 THR   A CG2 1 
ATOM   379  N N   . LEU   A 1 58  ? 17.56100  2.78200   -40.91200 1.000 37.95193 ? 254 LEU   A N   1 
ATOM   380  C CA  . LEU   A 1 58  ? 17.22200  2.57900   -39.50600 1.000 38.93951 ? 254 LEU   A CA  1 
ATOM   381  C C   . LEU   A 1 58  ? 18.40700  2.61700   -38.54100 1.000 39.84624 ? 254 LEU   A C   1 
ATOM   382  O O   . LEU   A 1 58  ? 18.20500  2.93100   -37.36300 1.000 41.19623 ? 254 LEU   A O   1 
ATOM   383  C CB  . LEU   A 1 58  ? 16.47000  1.25900   -39.32900 1.000 36.82956 ? 254 LEU   A CB  1 
ATOM   384  C CG  . LEU   A 1 58  ? 15.15700  1.16900   -40.10200 1.000 39.23582 ? 254 LEU   A CG  1 
ATOM   385  C CD1 . LEU   A 1 58  ? 14.52700  -0.22700  -40.01900 1.000 33.99173 ? 254 LEU   A CD1 1 
ATOM   386  C CD2 . LEU   A 1 58  ? 14.16500  2.25500   -39.64600 1.000 40.42623 ? 254 LEU   A CD2 1 
ATOM   387  N N   . VAL   A 1 59  ? 19.63200  2.30400   -38.96700 1.000 39.22664 ? 255 VAL   A N   1 
ATOM   388  C CA  . VAL   A 1 59  ? 20.78400  2.43700   -38.07400 1.000 40.83770 ? 255 VAL   A CA  1 
ATOM   389  C C   . VAL   A 1 59  ? 21.91700  3.13100   -38.82500 1.000 44.92243 ? 255 VAL   A C   1 
ATOM   390  O O   . VAL   A 1 59  ? 23.00300  2.56800   -39.00900 1.000 47.49728 ? 255 VAL   A O   1 
ATOM   391  C CB  . VAL   A 1 59  ? 21.22700  1.07900   -37.48800 1.000 40.74230 ? 255 VAL   A CB  1 
ATOM   392  C CG1 . VAL   A 1 59  ? 20.22500  0.61400   -36.46000 1.000 42.50623 ? 255 VAL   A CG1 1 
ATOM   393  C CG2 . VAL   A 1 59  ? 21.34400  0.01800   -38.56700 1.000 41.01557 ? 255 VAL   A CG2 1 
ATOM   394  N N   . ALA   A 1 60  ? 21.66900  4.38000   -39.22600 1.000 46.14949 ? 256 ALA   A N   1 
ATOM   395  C CA  . ALA   A 1 60  ? 22.50300  5.06500   -40.21300 1.000 47.77591 ? 256 ALA   A CA  1 
ATOM   396  C C   . ALA   A 1 60  ? 23.97000  5.18100   -39.80600 1.000 52.56000 ? 256 ALA   A C   1 
ATOM   397  O O   . ALA   A 1 60  ? 24.82600  5.35500   -40.68000 1.000 54.23301 ? 256 ALA   A O   1 
ATOM   398  C CB  . ALA   A 1 60  ? 21.92900  6.46000   -40.47700 1.000 47.96049 ? 256 ALA   A CB  1 
ATOM   399  N N   . LYS   A 1 61  ? 24.28600  5.08000   -38.51000 1.000 54.12529 ? 257 LYS   A N   1 
ATOM   400  C CA  . LYS   A 1 61  ? 25.65700  5.32800   -38.07000 1.000 58.37105 ? 257 LYS   A CA  1 
ATOM   401  C C   . LYS   A 1 61  ? 26.63300  4.28800   -38.61400 1.000 70.27623 ? 257 LYS   A C   1 
ATOM   402  O O   . LYS   A 1 61  ? 27.81900  4.59200   -38.79200 1.000 71.79286 ? 257 LYS   A O   1 
ATOM   403  C CB  . LYS   A 1 61  ? 25.72300  5.39000   -36.54400 1.000 64.16623 ? 257 LYS   A CB  1 
ATOM   404  C CG  . LYS   A 1 61  ? 27.12200  5.65500   -36.01000 1.000 59.69742 ? 257 LYS   A CG  1 
ATOM   405  C CD  . LYS   A 1 61  ? 27.11100  6.50200   -34.75300 1.000 54.93634 ? 257 LYS   A CD  1 
ATOM   406  C CE  . LYS   A 1 61  ? 28.36100  7.38500   -34.69700 1.000 53.59191 ? 257 LYS   A CE  1 
ATOM   407  N NZ  . LYS   A 1 61  ? 29.59900  6.64000   -34.31200 1.000 57.49257 ? 257 LYS   A NZ  1 
ATOM   408  N N   . LYS   A 1 70  ? 32.90200  -3.98700  -42.06100 1.000 44.75634 ? 266 LYS   A N   1 
ATOM   409  C CA  . LYS   A 1 70  ? 32.49600  -5.06500  -41.15700 1.000 45.22247 ? 266 LYS   A CA  1 
ATOM   410  C C   . LYS   A 1 70  ? 31.54900  -6.04400  -41.86800 1.000 39.71906 ? 266 LYS   A C   1 
ATOM   411  O O   . LYS   A 1 70  ? 30.70800  -5.63200  -42.65800 1.000 38.99764 ? 266 LYS   A O   1 
ATOM   412  C CB  . LYS   A 1 70  ? 31.83200  -4.49000  -39.90600 1.000 49.90447 ? 266 LYS   A CB  1 
ATOM   413  C CG  . LYS   A 1 70  ? 32.76100  -4.37500  -38.69600 1.000 57.45313 ? 266 LYS   A CG  1 
ATOM   414  C CD  . LYS   A 1 70  ? 32.08200  -3.60600  -37.56300 1.000 59.32412 ? 266 LYS   A CD  1 
ATOM   415  C CE  . LYS   A 1 70  ? 32.96600  -3.50100  -36.32000 1.000 62.59020 ? 266 LYS   A CE  1 
ATOM   416  N NZ  . LYS   A 1 70  ? 34.42100  -3.62800  -36.63100 1.000 64.52508 ? 266 LYS   A NZ  1 
ATOM   417  N N   . GLU   A 1 71  ? 31.71200  -7.33500  -41.58500 1.000 35.38172 ? 267 GLU   A N   1 
ATOM   418  C CA  . GLU   A 1 71  ? 30.89900  -8.36500  -42.21900 1.000 37.80369 ? 267 GLU   A CA  1 
ATOM   419  C C   . GLU   A 1 71  ? 29.42800  -8.15200  -41.88300 1.000 31.04851 ? 267 GLU   A C   1 
ATOM   420  O O   . GLU   A 1 71  ? 29.09200  -7.65400  -40.81200 1.000 32.65077 ? 267 GLU   A O   1 
ATOM   421  C CB  . GLU   A 1 71  ? 31.32900  -9.73800  -41.71700 1.000 38.03071 ? 267 GLU   A CB  1 
ATOM   422  C CG  . GLU   A 1 71  ? 32.18900  -10.52200 -42.66200 1.000 42.78623 ? 267 GLU   A CG  1 
ATOM   423  C CD  . GLU   A 1 71  ? 32.56600  -11.84900 -42.06900 1.000 40.94370 ? 267 GLU   A CD  1 
ATOM   424  O OE1 . GLU   A 1 71  ? 33.35200  -11.86800 -41.09700 1.000 47.51623 ? 267 GLU   A OE1 1 
ATOM   425  O OE2 . GLU   A 1 71  ? 32.04200  -12.87400 -42.54700 1.000 40.59319 ? 267 GLU   A OE2 1 
ATOM   426  N N   . ALA   A 1 72  ? 28.55200  -8.57400  -42.79800 1.000 34.78291 ? 268 ALA   A N   1 
ATOM   427  C CA  . ALA   A 1 72  ? 27.12000  -8.41500  -42.57400 1.000 31.63376 ? 268 ALA   A CA  1 
ATOM   428  C C   . ALA   A 1 72  ? 26.68500  -9.09400  -41.28000 1.000 30.25834 ? 268 ALA   A C   1 
ATOM   429  O O   . ALA   A 1 72  ? 25.91100  -8.53100  -40.49400 1.000 30.72111 ? 268 ALA   A O   1 
ATOM   430  C CB  . ALA   A 1 72  ? 26.34000  -8.98700  -43.76100 1.000 33.38199 ? 268 ALA   A CB  1 
ATOM   431  N N   . GLU   A 1 73  ? 27.18500  -10.30400 -41.04100 1.000 29.06400 ? 269 GLU   A N   1 
ATOM   432  C CA  . GLU   A 1 73  ? 26.81600  -11.04100 -39.83500 1.000 29.57072 ? 269 GLU   A CA  1 
ATOM   433  C C   . GLU   A 1 73  ? 27.26900  -10.32400 -38.57100 1.000 28.93398 ? 269 GLU   A C   1 
ATOM   434  O O   . GLU   A 1 73  ? 26.58400  -10.36100 -37.54300 1.000 27.25883 ? 269 GLU   A O   1 
ATOM   435  C CB  . GLU   A 1 73  ? 27.42300  -12.43900 -39.89300 1.000 29.69685 ? 269 GLU   A CB  1 
ATOM   436  C CG  . GLU   A 1 73  ? 26.75100  -13.34100 -40.89800 1.000 30.38089 ? 269 GLU   A CG  1 
ATOM   437  C CD  . GLU   A 1 73  ? 27.32100  -13.20900 -42.29400 1.000 31.05340 ? 269 GLU   A CD  1 
ATOM   438  O OE1 . GLU   A 1 73  ? 28.12400  -12.26200 -42.55200 1.000 31.27712 ? 269 GLU   A OE1 1 
ATOM   439  O OE2 . GLU   A 1 73  ? 26.96600  -14.05300 -43.13800 1.000 29.43536 ? 269 GLU   A OE2 1 
ATOM   440  N N   . VAL   A 1 74  ? 28.41300  -9.65700  -38.62900 1.000 28.60827 ? 270 VAL   A N   1 
ATOM   441  C CA  . VAL   A 1 74  ? 28.89200  -8.94700  -37.45900 1.000 27.83525 ? 270 VAL   A CA  1 
ATOM   442  C C   . VAL   A 1 74  ? 28.11400  -7.65200  -37.23700 1.000 30.66875 ? 270 VAL   A C   1 
ATOM   443  O O   . VAL   A 1 74  ? 27.84400  -7.26900  -36.09300 1.000 31.53766 ? 270 VAL   A O   1 
ATOM   444  C CB  . VAL   A 1 74  ? 30.40300  -8.72000  -37.60200 1.000 33.31366 ? 270 VAL   A CB  1 
ATOM   445  C CG1 . VAL   A 1 74  ? 30.92900  -7.91700  -36.43600 1.000 37.23971 ? 270 VAL   A CG1 1 
ATOM   446  C CG2 . VAL   A 1 74  ? 31.10200  -10.07800 -37.70400 1.000 33.77502 ? 270 VAL   A CG2 1 
ATOM   447  N N   . ARG   A 1 75  ? 27.71100  -6.96900  -38.31400 1.000 26.53265 ? 271 ARG   A N   1 
ATOM   448  C CA  . ARG   A 1 75  ? 26.84700  -5.80300  -38.14000 1.000 26.54993 ? 271 ARG   A CA  1 
ATOM   449  C C   . ARG   A 1 75  ? 25.50800  -6.19200  -37.53700 1.000 28.99323 ? 271 ARG   A C   1 
ATOM   450  O O   . ARG   A 1 75  ? 24.98100  -5.47300  -36.68700 1.000 27.82281 ? 271 ARG   A O   1 
ATOM   451  C CB  . ARG   A 1 75  ? 26.63200  -5.08000  -39.47600 1.000 28.76894 ? 271 ARG   A CB  1 
ATOM   452  C CG  . ARG   A 1 75  ? 27.92700  -4.78200  -40.20800 1.000 33.50502 ? 271 ARG   A CG  1 
ATOM   453  C CD  . ARG   A 1 75  ? 27.77500  -3.78900  -41.35800 1.000 35.98702 ? 271 ARG   A CD  1 
ATOM   454  N NE  . ARG   A 1 75  ? 26.73000  -4.15300  -42.30700 1.000 32.25298 ? 271 ARG   A NE  1 
ATOM   455  C CZ  . ARG   A 1 75  ? 26.94900  -4.76900  -43.46200 1.000 35.44541 ? 271 ARG   A CZ  1 
ATOM   456  N NH1 . ARG   A 1 75  ? 28.14900  -5.22000  -43.79200 1.000 34.74853 ? 271 ARG   A NH1 1 
ATOM   457  N NH2 . ARG   A 1 75  ? 25.93400  -4.96400  -44.29200 1.000 30.77698 ? 271 ARG   A NH2 1 
ATOM   458  N N   . ILE   A 1 76  ? 24.93400  -7.31200  -37.98200 1.000 29.58100 ? 272 ILE   A N   1 
ATOM   459  C CA  . ILE   A 1 76  ? 23.67300  -7.78500  -37.40100 1.000 26.40205 ? 272 ILE   A CA  1 
ATOM   460  C C   . ILE   A 1 76  ? 23.86800  -8.11100  -35.92900 1.000 28.80500 ? 272 ILE   A C   1 
ATOM   461  O O   . ILE   A 1 76  ? 23.07800  -7.70500  -35.06900 1.000 29.68342 ? 272 ILE   A O   1 
ATOM   462  C CB  . ILE   A 1 76  ? 23.16000  -9.01200  -38.16900 1.000 26.29531 ? 272 ILE   A CB  1 
ATOM   463  C CG1 . ILE   A 1 76  ? 22.68800  -8.62300  -39.57100 1.000 30.26100 ? 272 ILE   A CG1 1 
ATOM   464  C CG2 . ILE   A 1 76  ? 22.04000  -9.68700  -37.39200 1.000 27.08356 ? 272 ILE   A CG2 1 
ATOM   465  C CD1 . ILE   A 1 76  ? 22.57900  -9.81400  -40.50100 1.000 30.96006 ? 272 ILE   A CD1 1 
ATOM   466  N N   . PHE   A 1 77  ? 24.93000  -8.85500  -35.62600 1.000 27.72937 ? 273 PHE   A N   1 
ATOM   467  C CA  . PHE   A 1 77  ? 25.31700  -9.14800  -34.25000 1.000 28.17063 ? 273 PHE   A CA  1 
ATOM   468  C C   . PHE   A 1 77  ? 25.32000  -7.89300  -33.37600 1.000 33.57382 ? 273 PHE   A C   1 
ATOM   469  O O   . PHE   A 1 77  ? 24.81000  -7.92200  -32.25500 1.000 29.56768 ? 273 PHE   A O   1 
ATOM   470  C CB  . PHE   A 1 77  ? 26.69300  -9.83000  -34.27900 1.000 29.16166 ? 273 PHE   A CB  1 
ATOM   471  C CG  . PHE   A 1 77  ? 27.37900  -9.92300  -32.95800 1.000 28.65558 ? 273 PHE   A CG  1 
ATOM   472  C CD1 . PHE   A 1 77  ? 27.11200  -10.98300 -32.09900 1.000 29.71609 ? 273 PHE   A CD1 1 
ATOM   473  C CD2 . PHE   A 1 77  ? 28.31700  -8.97800  -32.58200 1.000 33.66241 ? 273 PHE   A CD2 1 
ATOM   474  C CE1 . PHE   A 1 77  ? 27.76900  -11.09000 -30.88900 1.000 31.74893 ? 273 PHE   A CE1 1 
ATOM   475  C CE2 . PHE   A 1 77  ? 28.97300  -9.07300  -31.36900 1.000 38.05350 ? 273 PHE   A CE2 1 
ATOM   476  C CZ  . PHE   A 1 77  ? 28.70500  -10.12900 -30.52500 1.000 37.65641 ? 273 PHE   A CZ  1 
ATOM   477  N N   . HIS   A 1 78  ? 25.85100  -6.76400  -33.87800 1.000 27.59570 ? 274 HIS   A N   1 
ATOM   478  C CA  . HIS   A 1 78  ? 25.84700  -5.54900  -33.06400 1.000 30.27239 ? 274 HIS   A CA  1 
ATOM   479  C C   . HIS   A 1 78  ? 24.44800  -4.95100  -32.89700 1.000 30.61668 ? 274 HIS   A C   1 
ATOM   480  O O   . HIS   A 1 78  ? 24.11500  -4.46500  -31.81400 1.000 34.03908 ? 274 HIS   A O   1 
ATOM   481  C CB  . HIS   A 1 78  ? 26.83700  -4.54100  -33.64200 1.000 34.36865 ? 274 HIS   A CB  1 
ATOM   482  C CG  . HIS   A 1 78  ? 28.25100  -4.89800  -33.31700 1.000 38.37577 ? 274 HIS   A CG  1 
ATOM   483  N ND1 . HIS   A 1 78  ? 28.67200  -5.11900  -32.02100 1.000 44.10623 ? 274 HIS   A ND1 1 
ATOM   484  C CD2 . HIS   A 1 78  ? 29.32000  -5.15100  -34.10900 1.000 41.57479 ? 274 HIS   A CD2 1 
ATOM   485  C CE1 . HIS   A 1 78  ? 29.94700  -5.46400  -32.02800 1.000 41.85279 ? 274 HIS   A CE1 1 
ATOM   486  N NE2 . HIS   A 1 78  ? 30.36500  -5.49000  -33.28200 1.000 48.61623 ? 274 HIS   A NE2 1 
ATOM   487  N N   . CYS   A 1 79  ? 23.62200  -4.97300  -33.94100 1.000 32.28850 ? 275 CYS   A N   1 
ATOM   488  C CA  . CYS   A 1 79  ? 22.22700  -4.56600  -33.79000 1.000 30.49664 ? 275 CYS   A CA  1 
ATOM   489  C C   . CYS   A 1 79  ? 21.50000  -5.44600  -32.78500 1.000 33.31655 ? 275 CYS   A C   1 
ATOM   490  O O   . CYS   A 1 79  ? 20.65100  -4.97000  -32.02000 1.000 35.54462 ? 275 CYS   A O   1 
ATOM   491  C CB  . CYS   A 1 79  ? 21.51700  -4.63000  -35.14100 1.000 32.47953 ? 275 CYS   A CB  1 
ATOM   492  S SG  . CYS   A 1 79  ? 22.06500  -3.35000  -36.26600 1.000 35.29492 ? 275 CYS   A SG  1 
ATOM   493  N N   . CYS   A 1 80  ? 21.78200  -6.74500  -32.80700 1.000 30.87405 ? 276 CYS   A N   1 
ATOM   494  C CA  . CYS   A 1 80  ? 21.09100  -7.65100  -31.90000 1.000 32.10510 ? 276 CYS   A CA  1 
ATOM   495  C C   . CYS   A 1 80  ? 21.47900  -7.35400  -30.45200 1.000 33.94015 ? 276 CYS   A C   1 
ATOM   496  O O   . CYS   A 1 80  ? 20.61800  -7.30100  -29.56700 1.000 32.76748 ? 276 CYS   A O   1 
ATOM   497  C CB  . CYS   A 1 80  ? 21.39000  -9.10600  -32.29800 1.000 29.52011 ? 276 CYS   A CB  1 
ATOM   498  S SG  . CYS   A 1 80  ? 20.75600  -9.70700  -33.88700 1.000 34.26005 ? 276 CYS   A SG  1 
ATOM   499  N N   . GLN   A 1 81  ? 22.76700  -7.09800  -30.19700 1.000 30.61183 ? 277 GLN   A N   1 
ATOM   500  C CA  . GLN   A 1 81  ? 23.19200  -6.66800  -28.86800 1.000 31.85343 ? 277 GLN   A CA  1 
ATOM   501  C C   . GLN   A 1 81  ? 22.48200  -5.39200  -28.43400 1.000 38.12623 ? 277 GLN   A C   1 
ATOM   502  O O   . GLN   A 1 81  ? 22.00000  -5.29600  -27.29700 1.000 34.99066 ? 277 GLN   A O   1 
ATOM   503  C CB  . GLN   A 1 81  ? 24.70000  -6.45900  -28.84400 1.000 31.23018 ? 277 GLN   A CB  1 
ATOM   504  C CG  . GLN   A 1 81  ? 25.50500  -7.69900  -28.98800 1.000 35.05257 ? 277 GLN   A CG  1 
ATOM   505  C CD  . GLN   A 1 81  ? 26.89800  -7.47100  -28.46900 1.000 35.93549 ? 277 GLN   A CD  1 
ATOM   506  O OE1 . GLN   A 1 81  ? 27.16100  -7.67300  -27.29900 1.000 32.23279 ? 277 GLN   A OE1 1 
ATOM   507  N NE2 . GLN   A 1 81  ? 27.79200  -7.01100  -29.33500 1.000 42.86623 ? 277 GLN   A NE2 1 
ATOM   508  N N   . CYS   A 1 82  ? 22.42300  -4.38800  -29.32100 1.000 34.45588 ? 278 CYS   A N   1 
ATOM   509  C CA  . CYS   A 1 82  ? 21.77200  -3.13300  -28.96200 1.000 36.12070 ? 278 CYS   A CA  1 
ATOM   510  C C   . CYS   A 1 82  ? 20.31700  -3.37800  -28.57100 1.000 33.31578 ? 278 CYS   A C   1 
ATOM   511  O O   . CYS   A 1 82  ? 19.84000  -2.83100  -27.57200 1.000 38.98078 ? 278 CYS   A O   1 
ATOM   512  C CB  . CYS   A 1 82  ? 21.87800  -2.11600  -30.11500 1.000 36.74579 ? 278 CYS   A CB  1 
ATOM   513  S SG  . CYS   A 1 82  ? 23.53700  -1.40000  -30.34100 1.000 45.46648 ? 278 CYS   A SG  1 
ATOM   514  N N   . THR   A 1 83  ? 19.61800  -4.24300  -29.32100 1.000 36.36851 ? 279 THR   A N   1 
ATOM   515  C CA  . THR   A 1 83  ? 18.26200  -4.67400  -28.96900 1.000 35.66477 ? 279 THR   A CA  1 
ATOM   516  C C   . THR   A 1 83  ? 18.21000  -5.20700  -27.53600 1.000 34.23939 ? 279 THR   A C   1 
ATOM   517  O O   . THR   A 1 83  ? 17.41100  -4.75900  -26.70000 1.000 33.09957 ? 279 THR   A O   1 
ATOM   518  C CB  . THR   A 1 83  ? 17.81300  -5.76400  -29.94600 1.000 33.26695 ? 279 THR   A CB  1 
ATOM   519  O OG1 . THR   A 1 83  ? 17.73900  -5.24500  -31.28000 1.000 40.83623 ? 279 THR   A OG1 1 
ATOM   520  C CG2 . THR   A 1 83  ? 16.45900  -6.37000  -29.55500 1.000 39.13623 ? 279 THR   A CG2 1 
ATOM   521  N N   . SER   A 1 84  ? 19.08500  -6.16100  -27.23100 1.000 33.34036 ? 280 SER   A N   1 
ATOM   522  C CA  . SER   A 1 84  ? 19.03000  -6.83300  -25.93700 1.000 27.26434 ? 280 SER   A CA  1 
ATOM   523  C C   . SER   A 1 84  ? 19.33500  -5.88400  -24.78600 1.000 25.42711 ? 280 SER   A C   1 
ATOM   524  O O   . SER   A 1 84  ? 18.76000  -6.01400  -23.70000 1.000 23.53093 ? 280 SER   A O   1 
ATOM   525  C CB  . SER   A 1 84  ? 20.02600  -7.98800  -25.94000 1.000 23.98725 ? 280 SER   A CB  1 
ATOM   526  O OG  . SER   A 1 84  ? 19.58200  -9.00900  -26.81600 1.000 29.66771 ? 280 SER   A OG  1 
ATOM   527  N N   . VAL   A 1 85  ? 20.28300  -4.97000  -24.98000 1.000 26.58453 ? 281 VAL   A N   1 
ATOM   528  C CA  . VAL   A 1 85  ? 20.63100  -4.02300  -23.92800 1.000 24.43590 ? 281 VAL   A CA  1 
ATOM   529  C C   . VAL   A 1 85  ? 19.41500  -3.18400  -23.53700 1.000 27.22691 ? 281 VAL   A C   1 
ATOM   530  O O   . VAL   A 1 85  ? 19.10700  -3.01600  -22.34900 1.000 26.15536 ? 281 VAL   A O   1 
ATOM   531  C CB  . VAL   A 1 85  ? 21.81200  -3.14600  -24.36600 1.000 32.99444 ? 281 VAL   A CB  1 
ATOM   532  C CG1 . VAL   A 1 85  ? 21.94800  -1.96100  -23.41100 1.000 27.66369 ? 281 VAL   A CG1 1 
ATOM   533  C CG2 . VAL   A 1 85  ? 23.08400  -3.97900  -24.36700 1.000 29.19146 ? 281 VAL   A CG2 1 
ATOM   534  N N   . GLU   A 1 86  ? 18.67900  -2.68900  -24.53700 1.000 29.90057 ? 282 GLU   A N   1 
ATOM   535  C CA  . GLU   A 1 86  ? 17.46100  -1.93500  -24.24700 1.000 30.94528 ? 282 GLU   A CA  1 
ATOM   536  C C   . GLU   A 1 86  ? 16.42300  -2.79300  -23.53000 1.000 29.18976 ? 282 GLU   A C   1 
ATOM   537  O O   . GLU   A 1 86  ? 15.77400  -2.32900  -22.58300 1.000 28.29660 ? 282 GLU   A O   1 
ATOM   538  C CB  . GLU   A 1 86  ? 16.88900  -1.35200  -25.54500 1.000 33.93927 ? 282 GLU   A CB  1 
ATOM   539  C CG  . GLU   A 1 86  ? 17.96000  -0.66000  -26.39300 1.000 38.18623 ? 282 GLU   A CG  1 
ATOM   540  C CD  . GLU   A 1 86  ? 18.16100  0.80000   -26.01700 1.000 44.90623 ? 282 GLU   A CD  1 
ATOM   541  O OE1 . GLU   A 1 86  ? 18.71100  1.57800   -26.84300 1.000 41.11981 ? 282 GLU   A OE1 1 
ATOM   542  O OE2 . GLU   A 1 86  ? 17.74700  1.17000   -24.89300 1.000 54.85623 ? 282 GLU   A OE2 1 
ATOM   543  N N   . THR   A 1 87  ? 16.26700  -4.05200  -23.94400 1.000 28.16539 ? 283 THR   A N   1 
ATOM   544  C CA  . THR   A 1 87  ? 15.28400  -4.92000  -23.30900 1.000 24.75022 ? 283 THR   A CA  1 
ATOM   545  C C   . THR   A 1 87  ? 15.66200  -5.21400  -21.86000 1.000 21.98451 ? 283 THR   A C   1 
ATOM   546  O O   . THR   A 1 87  ? 14.79400  -5.33500  -21.00000 1.000 24.59730 ? 283 THR   A O   1 
ATOM   547  C CB  . THR   A 1 87  ? 15.13400  -6.22300  -24.10700 1.000 29.51726 ? 283 THR   A CB  1 
ATOM   548  O OG1 . THR   A 1 87  ? 14.82200  -5.91400  -25.47000 1.000 28.97101 ? 283 THR   A OG1 1 
ATOM   549  C CG2 . THR   A 1 87  ? 14.02900  -7.11000  -23.55900 1.000 27.86338 ? 283 THR   A CG2 1 
ATOM   550  N N   . VAL   A 1 88  ? 16.95500  -5.38000  -21.58100 1.000 23.12816 ? 284 VAL   A N   1 
ATOM   551  C CA  . VAL   A 1 88  ? 17.36500  -5.62600  -20.19900 1.000 22.05909 ? 284 VAL   A CA  1 
ATOM   552  C C   . VAL   A 1 88  ? 16.96300  -4.44700  -19.32900 1.000 21.48054 ? 284 VAL   A C   1 
ATOM   553  O O   . VAL   A 1 88  ? 16.50600  -4.61800  -18.19200 1.000 23.08381 ? 284 VAL   A O   1 
ATOM   554  C CB  . VAL   A 1 88  ? 18.89100  -5.86500  -20.12800 1.000 24.88008 ? 284 VAL   A CB  1 
ATOM   555  C CG1 . VAL   A 1 88  ? 19.37900  -5.77800  -18.65900 1.000 26.03063 ? 284 VAL   A CG1 1 
ATOM   556  C CG2 . VAL   A 1 88  ? 19.23500  -7.20700  -20.74000 1.000 25.26789 ? 284 VAL   A CG2 1 
ATOM   557  N N   . THR   A 1 89  ? 17.11300  -3.23200  -19.86400 1.000 24.39404 ? 285 THR   A N   1 
ATOM   558  C CA  . THR   A 1 89  ? 16.69000  -2.03900  -19.13900 1.000 26.96260 ? 285 THR   A CA  1 
ATOM   559  C C   . THR   A 1 89  ? 15.19200  -2.06200  -18.87400 1.000 25.31507 ? 285 THR   A C   1 
ATOM   560  O O   . THR   A 1 89  ? 14.75300  -1.81100  -17.74800 1.000 24.47234 ? 285 THR   A O   1 
ATOM   561  C CB  . THR   A 1 89  ? 17.08700  -0.78600  -19.92100 1.000 30.79402 ? 285 THR   A CB  1 
ATOM   562  O OG1 . THR   A 1 89  ? 18.51400  -0.77400  -20.08300 1.000 36.75201 ? 285 THR   A OG1 1 
ATOM   563  C CG2 . THR   A 1 89  ? 16.65200  0.45700   -19.18300 1.000 33.71718 ? 285 THR   A CG2 1 
ATOM   564  N N   . GLU   A 1 90  ? 14.39700  -2.43200  -19.88000 1.000 23.87048 ? 286 GLU   A N   1 
ATOM   565  C CA  . GLU   A 1 90  ? 12.95300  -2.48500  -19.67700 1.000 23.22793 ? 286 GLU   A CA  1 
ATOM   566  C C   . GLU   A 1 90  ? 12.58800  -3.54000  -18.63200 1.000 22.74763 ? 286 GLU   A C   1 
ATOM   567  O O   . GLU   A 1 90  ? 11.72100  -3.31900  -17.77600 1.000 23.18514 ? 286 GLU   A O   1 
ATOM   568  C CB  . GLU   A 1 90  ? 12.23600  -2.78200  -21.00000 1.000 24.58468 ? 286 GLU   A CB  1 
ATOM   569  C CG  . GLU   A 1 90  ? 12.44800  -1.70500  -22.07900 1.000 25.28616 ? 286 GLU   A CG  1 
ATOM   570  C CD  . GLU   A 1 90  ? 11.58900  -1.94300  -23.31700 1.000 28.34080 ? 286 GLU   A CD  1 
ATOM   571  O OE1 . GLU   A 1 90  ? 11.29900  -0.95200  -24.01400 1.000 32.98114 ? 286 GLU   A OE1 1 
ATOM   572  O OE2 . GLU   A 1 90  ? 11.22900  -3.10600  -23.61000 1.000 29.46101 ? 286 GLU   A OE2 1 
ATOM   573  N N   . LEU   A 1 91  ? 13.25600  -4.69600  -18.67900 1.000 21.18033 ? 287 LEU   A N   1 
ATOM   574  C CA  . LEU   A 1 91  ? 12.95900  -5.76700  -17.73500 1.000 20.84113 ? 287 LEU   A CA  1 
ATOM   575  C C   . LEU   A 1 91  ? 13.31900  -5.37000  -16.30800 1.000 23.28291 ? 287 LEU   A C   1 
ATOM   576  O O   . LEU   A 1 91  ? 12.66600  -5.79800  -15.34700 1.000 21.17255 ? 287 LEU   A O   1 
ATOM   577  C CB  . LEU   A 1 91  ? 13.74700  -7.03000  -18.12700 1.000 21.27254 ? 287 LEU   A CB  1 
ATOM   578  C CG  . LEU   A 1 91  ? 13.05300  -7.86500  -19.20600 1.000 24.04080 ? 287 LEU   A CG  1 
ATOM   579  C CD1 . LEU   A 1 91  ? 14.04700  -8.79000  -19.91100 1.000 25.16697 ? 287 LEU   A CD1 1 
ATOM   580  C CD2 . LEU   A 1 91  ? 11.92500  -8.69300  -18.56400 1.000 22.55189 ? 287 LEU   A CD2 1 
ATOM   581  N N   . THR   A 1 92  ? 14.41000  -4.62200  -16.15800 1.000 22.83341 ? 288 THR   A N   1 
ATOM   582  C CA  . THR   A 1 92  ? 14.81100  -4.16300  -14.83100 1.000 24.05108 ? 288 THR   A CA  1 
ATOM   583  C C   . THR   A 1 92  ? 13.76800  -3.21900  -14.24700 1.000 24.66855 ? 288 THR   A C   1 
ATOM   584  O O   . THR   A 1 92  ? 13.40400  -3.34500  -13.06600 1.000 24.83575 ? 288 THR   A O   1 
ATOM   585  C CB  . THR   A 1 92  ? 16.18300  -3.48600  -14.89100 1.000 25.47107 ? 288 THR   A CB  1 
ATOM   586  O OG1 . THR   A 1 92  ? 17.16200  -4.43400  -15.33300 1.000 26.62198 ? 288 THR   A OG1 1 
ATOM   587  C CG2 . THR   A 1 92  ? 16.57900  -2.97700  -13.50600 1.000 28.31400 ? 288 THR   A CG2 1 
ATOM   588  N N   . GLU   A 1 93  ? 13.25600  -2.28900  -15.06800 1.000 23.84448 ? 289 GLU   A N   1 
ATOM   589  C CA  . GLU   A 1 93  ? 12.19100  -1.40600  -14.59800 1.000 24.31430 ? 289 GLU   A CA  1 
ATOM   590  C C   . GLU   A 1 93  ? 10.92800  -2.19800  -14.29600 1.000 25.95551 ? 289 GLU   A C   1 
ATOM   591  O O   . GLU   A 1 93  ? 10.26600  -1.96600  -13.28100 1.000 25.95783 ? 289 GLU   A O   1 
ATOM   592  C CB  . GLU   A 1 93  ? 11.90500  -0.31200  -15.63100 1.000 29.50188 ? 289 GLU   A CB  1 
ATOM   593  C CG  . GLU   A 1 93  ? 13.04300  0.69400   -15.81700 1.000 32.94037 ? 289 GLU   A CG  1 
ATOM   594  C CD  . GLU   A 1 93  ? 13.45000  1.37000   -14.50800 1.000 40.96623 ? 289 GLU   A CD  1 
ATOM   595  O OE1 . GLU   A 1 93  ? 14.64200  1.28400   -14.12800 1.000 40.92851 ? 289 GLU   A OE1 1 
ATOM   596  O OE2 . GLU   A 1 93  ? 12.57500  1.97100   -13.84700 1.000 40.43909 ? 289 GLU   A OE2 1 
ATOM   597  N N   . PHE   A 1 94  ? 10.58200  -3.14600  -15.16500 1.000 24.20072 ? 290 PHE   A N   1 
ATOM   598  C CA  . PHE   A 1 94  ? 9.45200   -4.01900  -14.87200 1.000 20.46289 ? 290 PHE   A CA  1 
ATOM   599  C C   . PHE   A 1 94  ? 9.63400   -4.73100  -13.53200 1.000 24.17461 ? 290 PHE   A C   1 
ATOM   600  O O   . PHE   A 1 94  ? 8.71800   -4.76600  -12.69000 1.000 23.39602 ? 290 PHE   A O   1 
ATOM   601  C CB  . PHE   A 1 94  ? 9.27500   -5.04100  -16.00700 1.000 18.61387 ? 290 PHE   A CB  1 
ATOM   602  C CG  . PHE   A 1 94  ? 8.22900   -6.09800  -15.72800 1.000 19.89771 ? 290 PHE   A CG  1 
ATOM   603  C CD1 . PHE   A 1 94  ? 6.87700   -5.77700  -15.69300 1.000 17.37087 ? 290 PHE   A CD1 1 
ATOM   604  C CD2 . PHE   A 1 94  ? 8.59500   -7.41400  -15.50500 1.000 20.68841 ? 290 PHE   A CD2 1 
ATOM   605  C CE1 . PHE   A 1 94  ? 5.92000   -6.74500  -15.47300 1.000 18.84482 ? 290 PHE   A CE1 1 
ATOM   606  C CE2 . PHE   A 1 94  ? 7.65000   -8.40000  -15.26700 1.000 22.80610 ? 290 PHE   A CE2 1 
ATOM   607  C CZ  . PHE   A 1 94  ? 6.28600   -8.07800  -15.25200 1.000 19.20486 ? 290 PHE   A CZ  1 
ATOM   608  N N   . ALA   A 1 95  ? 10.81100  -5.32300  -13.31800 1.000 23.65420 ? 291 ALA   A N   1 
ATOM   609  C CA  . ALA   A 1 95  ? 11.04400  -6.06200  -12.08100 1.000 23.99463 ? 291 ALA   A CA  1 
ATOM   610  C C   . ALA   A 1 95  ? 10.85300  -5.16800  -10.85900 1.000 24.37601 ? 291 ALA   A C   1 
ATOM   611  O O   . ALA   A 1 95  ? 10.21900  -5.56900  -9.88000  1.000 26.34456 ? 291 ALA   A O   1 
ATOM   612  C CB  . ALA   A 1 95  ? 12.45700  -6.65500  -12.08900 1.000 22.04729 ? 291 ALA   A CB  1 
ATOM   613  N N   . LYS   A 1 96  ? 11.37400  -3.94100  -10.91900 1.000 27.84900 ? 292 LYS   A N   1 
ATOM   614  C CA  . LYS   A 1 96  ? 11.26100  -3.03400  -9.77900  1.000 28.50000 ? 292 LYS   A CA  1 
ATOM   615  C C   . LYS   A 1 96  ? 9.81700   -2.69200  -9.47300  1.000 29.89820 ? 292 LYS   A C   1 
ATOM   616  O O   . LYS   A 1 96  ? 9.50600   -2.27500  -8.35000  1.000 29.23837 ? 292 LYS   A O   1 
ATOM   617  C CB  . LYS   A 1 96  ? 12.08200  -1.78100  -10.07300 1.000 31.65289 ? 292 LYS   A CB  1 
ATOM   618  C CG  . LYS   A 1 96  ? 13.57000  -2.04000  -9.84900  1.000 34.93594 ? 292 LYS   A CG  1 
ATOM   619  C CD  . LYS   A 1 96  ? 14.41200  -0.78100  -9.68400  1.000 47.06623 ? 292 LYS   A CD  1 
ATOM   620  C CE  . LYS   A 1 96  ? 14.07200  0.29800   -10.68900 1.000 45.57623 ? 292 LYS   A CE  1 
ATOM   621  N NZ  . LYS   A 1 96  ? 15.29600  1.08200   -11.03700 1.000 41.49729 ? 292 LYS   A NZ  1 
ATOM   622  N N   . ALA   A 1 97  ? 8.91500   -2.88600  -10.43400 1.000 26.50667 ? 293 ALA   A N   1 
ATOM   623  C CA  . ALA   A 1 97  ? 7.50700   -2.63300  -10.19700 1.000 26.90868 ? 293 ALA   A CA  1 
ATOM   624  C C   . ALA   A 1 97  ? 6.74000   -3.87900  -9.78600  1.000 26.89667 ? 293 ALA   A C   1 
ATOM   625  O O   . ALA   A 1 97  ? 5.54300   -3.77500  -9.49300  1.000 29.42510 ? 293 ALA   A O   1 
ATOM   626  C CB  . ALA   A 1 97  ? 6.87300   -2.02800  -11.46300 1.000 26.60622 ? 293 ALA   A CB  1 
ATOM   627  N N   . ILE   A 1 98  ? 7.37300   -5.05400  -9.77100  1.000 26.45557 ? 294 ILE   A N   1 
ATOM   628  C CA  . ILE   A 1 98  ? 6.69500   -6.26300  -9.29500  1.000 25.75992 ? 294 ILE   A CA  1 
ATOM   629  C C   . ILE   A 1 98  ? 6.52400   -6.09600  -7.79200  1.000 29.12273 ? 294 ILE   A C   1 
ATOM   630  O O   . ILE   A 1 98  ? 7.52500   -5.91600  -7.08000  1.000 28.38566 ? 294 ILE   A O   1 
ATOM   631  C CB  . ILE   A 1 98  ? 7.47500   -7.55700  -9.60700  1.000 24.90479 ? 294 ILE   A CB  1 
ATOM   632  C CG1 . ILE   A 1 98  ? 7.56800   -7.78900  -11.11000 1.000 23.45305 ? 294 ILE   A CG1 1 
ATOM   633  C CG2 . ILE   A 1 98  ? 6.81100   -8.73800  -8.93500  1.000 27.25107 ? 294 ILE   A CG2 1 
ATOM   634  C CD1 . ILE   A 1 98  ? 8.52700   -8.94000  -11.43300 1.000 28.02242 ? 294 ILE   A CD1 1 
ATOM   635  N N   . PRO   A 1 99  ? 5.29900   -6.10800  -7.27300  1.000 29.56140 ? 295 PRO   A N   1 
ATOM   636  C CA  . PRO   A 1 99  ? 5.10900   -5.98800  -5.81800  1.000 32.45492 ? 295 PRO   A CA  1 
ATOM   637  C C   . PRO   A 1 99  ? 6.02600   -6.90300  -5.01500  1.000 30.65099 ? 295 PRO   A C   1 
ATOM   638  O O   . PRO   A 1 99  ? 6.06900   -8.11500  -5.25000  1.000 33.44897 ? 295 PRO   A O   1 
ATOM   639  C CB  . PRO   A 1 99  ? 3.62500   -6.35100  -5.64400  1.000 29.96148 ? 295 PRO   A CB  1 
ATOM   640  C CG  . PRO   A 1 99  ? 2.99100   -5.86100  -6.93500  1.000 28.17634 ? 295 PRO   A CG  1 
ATOM   641  C CD  . PRO   A 1 99  ? 4.01700   -6.20200  -7.99600  1.000 26.50830 ? 295 PRO   A CD  1 
ATOM   642  N N   . GLY   A 1 100 ? 6.81000   -6.32200  -4.10000  1.000 30.05014 ? 296 GLY   A N   1 
ATOM   643  C CA  . GLY   A 1 100 ? 7.73100   -7.06700  -3.25100  1.000 28.74285 ? 296 GLY   A CA  1 
ATOM   644  C C   . GLY   A 1 100 ? 9.17000   -7.13600  -3.74600  1.000 33.02914 ? 296 GLY   A C   1 
ATOM   645  O O   . GLY   A 1 100 ? 10.08000  -7.38900  -2.94200  1.000 28.80943 ? 296 GLY   A O   1 
ATOM   646  N N   . PHE   A 1 101 ? 9.40300   -6.94500  -5.04600  1.000 27.11755 ? 297 PHE   A N   1 
ATOM   647  C CA  . PHE   A 1 101 ? 10.75300  -7.15000  -5.56800  1.000 24.16715 ? 297 PHE   A CA  1 
ATOM   648  C C   . PHE   A 1 101 ? 11.73500  -6.16300  -4.94800  1.000 27.57478 ? 297 PHE   A C   1 
ATOM   649  O O   . PHE   A 1 101 ? 12.86600  -6.52800  -4.58900  1.000 26.92202 ? 297 PHE   A O   1 
ATOM   650  C CB  . PHE   A 1 101 ? 10.71900  -7.04200  -7.10000  1.000 23.76931 ? 297 PHE   A CB  1 
ATOM   651  C CG  . PHE   A 1 101 ? 12.05000  -7.32900  -7.76200  1.000 24.02520 ? 297 PHE   A CG  1 
ATOM   652  C CD1 . PHE   A 1 101 ? 12.40600  -8.63300  -8.11100  1.000 24.35727 ? 297 PHE   A CD1 1 
ATOM   653  C CD2 . PHE   A 1 101 ? 12.91200  -6.29200  -8.05700  1.000 22.96622 ? 297 PHE   A CD2 1 
ATOM   654  C CE1 . PHE   A 1 101 ? 13.66000  -8.89100  -8.72900  1.000 24.03978 ? 297 PHE   A CE1 1 
ATOM   655  C CE2 . PHE   A 1 101 ? 14.15500  -6.55900  -8.69000  1.000 23.97158 ? 297 PHE   A CE2 1 
ATOM   656  C CZ  . PHE   A 1 101 ? 14.50800  -7.85300  -9.00500  1.000 24.68247 ? 297 PHE   A CZ  1 
ATOM   657  N N   . ALA   A 1 102 ? 11.32100  -4.90900  -4.80700  1.000 26.29998 ? 298 ALA   A N   1 
ATOM   658  C CA  . ALA   A 1 102 ? 12.23400  -3.88300  -4.31400  1.000 30.72886 ? 298 ALA   A CA  1 
ATOM   659  C C   . ALA   A 1 102 ? 12.48800  -4.00600  -2.82200  1.000 29.93166 ? 298 ALA   A C   1 
ATOM   660  O O   . ALA   A 1 102 ? 13.37600  -3.31700  -2.30900  1.000 33.98877 ? 298 ALA   A O   1 
ATOM   661  C CB  . ALA   A 1 102 ? 11.68800  -2.48900  -4.63600  1.000 33.65117 ? 298 ALA   A CB  1 
ATOM   662  N N   . ASN   A 1 103 ? 11.74800  -4.86600  -2.12600  1.000 34.07537 ? 299 ASN   A N   1 
ATOM   663  C CA  . ASN   A 1 103 ? 12.04100  -5.17200  -0.73000  1.000 30.36147 ? 299 ASN   A CA  1 
ATOM   664  C C   . ASN   A 1 103 ? 13.08800  -6.26200  -0.56900  1.000 33.90884 ? 299 ASN   A C   1 
ATOM   665  O O   . ASN   A 1 103 ? 13.48200  -6.56200  0.56800   1.000 36.43440 ? 299 ASN   A O   1 
ATOM   666  C CB  . ASN   A 1 103 ? 10.75700  -5.58400  -0.00000  1.000 33.88582 ? 299 ASN   A CB  1 
ATOM   667  C CG  . ASN   A 1 103 ? 9.62500   -4.60000  -0.21500  1.000 37.10286 ? 299 ASN   A CG  1 
ATOM   668  O OD1 . ASN   A 1 103 ? 8.66400   -4.89000  -0.91900  1.000 43.04623 ? 299 ASN   A OD1 1 
ATOM   669  N ND2 . ASN   A 1 103 ? 9.73700   -3.42500  0.39400   1.000 41.14623 ? 299 ASN   A ND2 1 
ATOM   670  N N   . LEU   A 1 104 ? 13.56600  -6.85800  -1.66300  1.000 29.69013 ? 300 LEU   A N   1 
ATOM   671  C CA  . LEU   A 1 104 ? 14.61100  -7.85900  -1.58000  1.000 30.57871 ? 300 LEU   A CA  1 
ATOM   672  C C   . LEU   A 1 104 ? 15.97200  -7.19900  -1.39600  1.000 31.42525 ? 300 LEU   A C   1 
ATOM   673  O O   . LEU   A 1 104 ? 16.18300  -6.03300  -1.74800  1.000 31.05110 ? 300 LEU   A O   1 
ATOM   674  C CB  . LEU   A 1 104 ? 14.62200  -8.73200  -2.85300  1.000 27.04772 ? 300 LEU   A CB  1 
ATOM   675  C CG  . LEU   A 1 104 ? 13.33500  -9.53300  -3.11300  1.000 30.41763 ? 300 LEU   A CG  1 
ATOM   676  C CD1 . LEU   A 1 104 ? 13.33900  -10.15000 -4.52600  1.000 27.93908 ? 300 LEU   A CD1 1 
ATOM   677  C CD2 . LEU   A 1 104 ? 13.09700  -10.61000 -2.06300  1.000 32.50318 ? 300 LEU   A CD2 1 
ATOM   678  N N   . ASP   A 1 105 ? 16.88500  -7.96300  -0.79900  1.000 30.25792 ? 301 ASP   A N   1 
ATOM   679  C CA  . ASP   A 1 105 ? 18.30300  -7.62600  -0.79800  1.000 35.52172 ? 301 ASP   A CA  1 
ATOM   680  C C   . ASP   A 1 105 ? 18.72600  -7.19600  -2.19100  1.000 37.20816 ? 301 ASP   A C   1 
ATOM   681  O O   . ASP   A 1 105 ? 18.38400  -7.84700  -3.18300  1.000 33.99565 ? 301 ASP   A O   1 
ATOM   682  C CB  . ASP   A 1 105 ? 19.11400  -8.84100  -0.34800  1.000 37.35909 ? 301 ASP   A CB  1 
ATOM   683  C CG  . ASP   A 1 105 ? 20.56500  -8.50800  -0.04600  1.000 44.61623 ? 301 ASP   A CG  1 
ATOM   684  O OD1 . ASP   A 1 105 ? 20.86900  -8.14500  1.11500   1.000 50.63623 ? 301 ASP   A OD1 1 
ATOM   685  O OD2 . ASP   A 1 105 ? 21.40400  -8.62000  -0.97600  1.000 46.16623 ? 301 ASP   A OD2 1 
ATOM   686  N N   . LEU   A 1 106 ? 19.45600  -6.08400  -2.26700  1.000 33.64438 ? 302 LEU   A N   1 
ATOM   687  C CA  . LEU   A 1 106 ? 19.87600  -5.58100  -3.57100  1.000 35.82064 ? 302 LEU   A CA  1 
ATOM   688  C C   . LEU   A 1 106 ? 20.70100  -6.61800  -4.33200  1.000 35.24842 ? 302 LEU   A C   1 
ATOM   689  O O   . LEU   A 1 106 ? 20.57200  -6.74400  -5.55700  1.000 31.43957 ? 302 LEU   A O   1 
ATOM   690  C CB  . LEU   A 1 106 ? 20.66000  -4.28000  -3.40500  1.000 37.85954 ? 302 LEU   A CB  1 
ATOM   691  C CG  . LEU   A 1 106 ? 21.09700  -3.61900  -4.71400  1.000 41.50129 ? 302 LEU   A CG  1 
ATOM   692  C CD1 . LEU   A 1 106 ? 19.88800  -3.50100  -5.64400  1.000 37.79364 ? 302 LEU   A CD1 1 
ATOM   693  C CD2 . LEU   A 1 106 ? 21.70200  -2.23700  -4.45600  1.000 44.78929 ? 302 LEU   A CD2 1 
ATOM   694  N N   . ASN   A 1 107 ? 21.54000  -7.38500  -3.63400  1.000 34.32992 ? 303 ASN   A N   1 
ATOM   695  C CA  . ASN   A 1 107 ? 22.34500  -8.37400  -4.33600  1.000 34.59247 ? 303 ASN   A CA  1 
ATOM   696  C C   . ASN   A 1 107 ? 21.48700  -9.51500  -4.87100  1.000 33.12935 ? 303 ASN   A C   1 
ATOM   697  O O   . ASN   A 1 107 ? 21.83000  -10.11000 -5.89600  1.000 31.70908 ? 303 ASN   A O   1 
ATOM   698  C CB  . ASN   A 1 107 ? 23.44500  -8.92700  -3.42500  1.000 37.67495 ? 303 ASN   A CB  1 
ATOM   699  C CG  . ASN   A 1 107 ? 24.56600  -7.93800  -3.20900  1.000 41.33938 ? 303 ASN   A CG  1 
ATOM   700  O OD1 . ASN   A 1 107 ? 25.08900  -7.35900  -4.15500  1.000 40.62996 ? 303 ASN   A OD1 1 
ATOM   701  N ND2 . ASN   A 1 107 ? 24.95600  -7.75700  -1.95500  1.000 48.21623 ? 303 ASN   A ND2 1 
ATOM   702  N N   . ASP   A 1 108 ? 20.38400  -9.82900  -4.19100  1.000 32.25352 ? 304 ASP   A N   1 
ATOM   703  C CA  . ASP   A 1 108 ? 19.46700  -10.84200 -4.69000  1.000 32.80458 ? 304 ASP   A CA  1 
ATOM   704  C C   . ASP   A 1 108 ? 18.69500  -10.31600 -5.89000  1.000 26.51043 ? 304 ASP   A C   1 
ATOM   705  O O   . ASP   A 1 108 ? 18.43700  -11.06500 -6.83700  1.000 27.91598 ? 304 ASP   A O   1 
ATOM   706  C CB  . ASP   A 1 108 ? 18.49800  -11.27800 -3.58900  1.000 29.53936 ? 304 ASP   A CB  1 
ATOM   707  C CG  . ASP   A 1 108 ? 19.11000  -12.29200 -2.63000  1.000 38.44138 ? 304 ASP   A CG  1 
ATOM   708  O OD1 . ASP   A 1 108 ? 20.23200  -12.77700 -2.89300  1.000 36.17881 ? 304 ASP   A OD1 1 
ATOM   709  O OD2 . ASP   A 1 108 ? 18.45100  -12.60800 -1.61800  1.000 39.59812 ? 304 ASP   A OD2 1 
ATOM   710  N N   . GLN   A 1 109 ? 18.31800  -9.03700  -5.86700  1.000 25.58893 ? 305 GLN   A N   1 
ATOM   711  C CA  . GLN   A 1 109 ? 17.70400  -8.45400  -7.05900  1.000 28.29795 ? 305 GLN   A CA  1 
ATOM   712  C C   . GLN   A 1 109 ? 18.61400  -8.62000  -8.26800  1.000 28.03785 ? 305 GLN   A C   1 
ATOM   713  O O   . GLN   A 1 109 ? 18.15100  -8.98000  -9.35200  1.000 26.17601 ? 305 GLN   A O   1 
ATOM   714  C CB  . GLN   A 1 109 ? 17.39100  -6.97600  -6.84500  1.000 25.72135 ? 305 GLN   A CB  1 
ATOM   715  C CG  . GLN   A 1 109 ? 16.42900  -6.71600  -5.70700  1.000 27.27144 ? 305 GLN   A CG  1 
ATOM   716  C CD  . GLN   A 1 109 ? 16.07600  -5.24700  -5.53000  1.000 27.96748 ? 305 GLN   A CD  1 
ATOM   717  O OE1 . GLN   A 1 109 ? 15.97000  -4.49600  -6.49400  1.000 29.84388 ? 305 GLN   A OE1 1 
ATOM   718  N NE2 . GLN   A 1 109 ? 15.92700  -4.82200  -4.27200  1.000 30.98859 ? 305 GLN   A NE2 1 
ATOM   719  N N   . VAL   A 1 110 ? 19.92100  -8.37300  -8.09800  1.000 29.32558 ? 306 VAL   A N   1 
ATOM   720  C CA  . VAL   A 1 110 ? 20.86500  -8.52900  -9.20400  1.000 28.34647 ? 306 VAL   A CA  1 
ATOM   721  C C   . VAL   A 1 110 ? 20.88900  -9.97900  -9.68300  1.000 27.41868 ? 306 VAL   A C   1 
ATOM   722  O O   . VAL   A 1 110 ? 20.85900  -10.25700 -10.89100 1.000 27.18656 ? 306 VAL   A O   1 
ATOM   723  C CB  . VAL   A 1 110 ? 22.27400  -8.06900  -8.77500  1.000 30.87266 ? 306 VAL   A CB  1 
ATOM   724  C CG1 . VAL   A 1 110 ? 23.33000  -8.50100  -9.81400  1.000 30.76763 ? 306 VAL   A CG1 1 
ATOM   725  C CG2 . VAL   A 1 110 ? 22.32800  -6.55800  -8.49500  1.000 30.48367 ? 306 VAL   A CG2 1 
ATOM   726  N N   . THR   A 1 111 ? 20.98000  -10.91700 -8.73900  1.000 27.89187 ? 307 THR   A N   1 
ATOM   727  C CA  . THR   A 1 111 ? 20.97900  -12.34000 -9.05800  1.000 26.02660 ? 307 THR   A CA  1 
ATOM   728  C C   . THR   A 1 111 ? 19.73200  -12.74100 -9.84200  1.000 24.33090 ? 307 THR   A C   1 
ATOM   729  O O   . THR   A 1 111 ? 19.82700  -13.43800 -10.85700 1.000 22.98995 ? 307 THR   A O   1 
ATOM   730  C CB  . THR   A 1 111 ? 21.07800  -13.15000 -7.77100  1.000 27.99198 ? 307 THR   A CB  1 
ATOM   731  O OG1 . THR   A 1 111 ? 22.37100  -12.89700 -7.18900  1.000 31.89243 ? 307 THR   A OG1 1 
ATOM   732  C CG2 . THR   A 1 111 ? 20.97100  -14.62700 -8.05700  1.000 30.00506 ? 307 THR   A CG2 1 
ATOM   733  N N   . LEU   A 1 112 ? 18.55400  -12.31600 -9.36900  1.000 24.98739 ? 308 LEU   A N   1 
ATOM   734  C CA  . LEU   A 1 112 ? 17.31300  -12.64600 -10.08500 1.000 22.07937 ? 308 LEU   A CA  1 
ATOM   735  C C   . LEU   A 1 112 ? 17.32500  -12.09200 -11.50600 1.000 24.67528 ? 308 LEU   A C   1 
ATOM   736  O O   . LEU   A 1 112 ? 16.91700  -12.78300 -12.45300 1.000 21.91580 ? 308 LEU   A O   1 
ATOM   737  C CB  . LEU   A 1 112 ? 16.10500  -12.11400 -9.30300  1.000 20.96144 ? 308 LEU   A CB  1 
ATOM   738  C CG  . LEU   A 1 112 ? 15.88800  -12.84900 -7.97600  1.000 21.54296 ? 308 LEU   A CG  1 
ATOM   739  C CD1 . LEU   A 1 112 ? 14.64300  -12.29000 -7.27800  1.000 26.15744 ? 308 LEU   A CD1 1 
ATOM   740  C CD2 . LEU   A 1 112 ? 15.78700  -14.36300 -8.14800  1.000 24.15298 ? 308 LEU   A CD2 1 
ATOM   741  N N   . LEU   A 1 113 ? 17.75500  -10.84400 -11.68600 1.000 23.48752 ? 309 LEU   A N   1 
ATOM   742  C CA  . LEU   A 1 113 ? 17.77800  -10.30700 -13.04300 1.000 25.39083 ? 309 LEU   A CA  1 
ATOM   743  C C   . LEU   A 1 113 ? 18.82900  -11.01500 -13.88000 1.000 22.54607 ? 309 LEU   A C   1 
ATOM   744  O O   . LEU   A 1 113 ? 18.59100  -11.32700 -15.04500 1.000 21.30816 ? 309 LEU   A O   1 
ATOM   745  C CB  . LEU   A 1 113 ? 18.02900  -8.80000  -13.03000 1.000 25.87520 ? 309 LEU   A CB  1 
ATOM   746  C CG  . LEU   A 1 113 ? 16.82400  -7.89400  -12.75000 1.000 32.34623 ? 309 LEU   A CG  1 
ATOM   747  C CD1 . LEU   A 1 113 ? 17.34800  -6.49300  -12.53100 1.000 38.89623 ? 309 LEU   A CD1 1 
ATOM   748  C CD2 . LEU   A 1 113 ? 15.83300  -7.89100  -13.90000 1.000 31.45567 ? 309 LEU   A CD2 1 
ATOM   749  N N   . LYS   A 1 114 ? 20.00900  -11.28500 -13.30400 1.000 21.87721 ? 310 LYS   A N   1 
ATOM   750  C CA  . LYS   A 1 114 ? 21.08100  -11.90800 -14.07500 1.000 23.98654 ? 310 LYS   A CA  1 
ATOM   751  C C   . LYS   A 1 114 ? 20.63800  -13.22200 -14.71100 1.000 21.35085 ? 310 LYS   A C   1 
ATOM   752  O O   . LYS   A 1 114 ? 20.86500  -13.45800 -15.90700 1.000 25.30996 ? 310 LYS   A O   1 
ATOM   753  C CB  . LYS   A 1 114 ? 22.28800  -12.16500 -13.16200 1.000 23.44068 ? 310 LYS   A CB  1 
ATOM   754  C CG  . LYS   A 1 114 ? 23.40700  -12.95800 -13.84400 1.000 25.15324 ? 310 LYS   A CG  1 
ATOM   755  C CD  . LYS   A 1 114 ? 24.44900  -13.30000 -12.77400 1.000 30.10562 ? 310 LYS   A CD  1 
ATOM   756  C CE  . LYS   A 1 114 ? 25.67400  -13.95700 -13.37500 1.000 32.19443 ? 310 LYS   A CE  1 
ATOM   757  N NZ  . LYS   A 1 114 ? 26.42700  -12.98200 -14.20800 1.000 29.41456 ? 310 LYS   A NZ  1 
ATOM   758  N N   . TYR   A 1 115 ? 20.00100  -14.08500 -13.92000 1.000 22.69165 ? 311 TYR   A N   1 
ATOM   759  C CA  . TYR   A 1 115 ? 19.57200  -15.38800 -14.41300 1.000 26.72849 ? 311 TYR   A CA  1 
ATOM   760  C C   . TYR   A 1 115 ? 18.21700  -15.35800 -15.08300 1.000 27.00516 ? 311 TYR   A C   1 
ATOM   761  O O   . TYR   A 1 115 ? 17.92000  -16.25900 -15.88200 1.000 27.35809 ? 311 TYR   A O   1 
ATOM   762  C CB  . TYR   A 1 115 ? 19.55000  -16.41300 -13.27200 1.000 26.41282 ? 311 TYR   A CB  1 
ATOM   763  C CG  . TYR   A 1 115 ? 20.95300  -16.80000 -12.87400 1.000 30.56297 ? 311 TYR   A CG  1 
ATOM   764  C CD1 . TYR   A 1 115 ? 21.68000  -17.68500 -13.65700 1.000 37.34671 ? 311 TYR   A CD1 1 
ATOM   765  C CD2 . TYR   A 1 115 ? 21.56500  -16.24900 -11.75700 1.000 28.96323 ? 311 TYR   A CD2 1 
ATOM   766  C CE1 . TYR   A 1 115 ? 22.97100  -18.02500 -13.33200 1.000 40.21913 ? 311 TYR   A CE1 1 
ATOM   767  C CE2 . TYR   A 1 115 ? 22.87400  -16.57400 -11.43000 1.000 36.98587 ? 311 TYR   A CE2 1 
ATOM   768  C CZ  . TYR   A 1 115 ? 23.56100  -17.47200 -12.22300 1.000 40.04450 ? 311 TYR   A CZ  1 
ATOM   769  O OH  . TYR   A 1 115 ? 24.85000  -17.83100 -11.92000 1.000 43.85195 ? 311 TYR   A OH  1 
ATOM   770  N N   . GLY   A 1 116 ? 17.41900  -14.32600 -14.83500 1.000 21.55436 ? 312 GLY   A N   1 
ATOM   771  C CA  . GLY   A 1 116 ? 16.07400  -14.28900 -15.38500 1.000 22.83621 ? 312 GLY   A CA  1 
ATOM   772  C C   . GLY   A 1 116 ? 15.93300  -13.56700 -16.70500 1.000 23.02183 ? 312 GLY   A C   1 
ATOM   773  O O   . GLY   A 1 116 ? 15.04500  -13.93100 -17.49300 1.000 20.52483 ? 312 GLY   A O   1 
ATOM   774  N N   . VAL   A 1 117 ? 16.76900  -12.56300 -16.98700 1.000 21.17501 ? 313 VAL   A N   1 
ATOM   775  C CA  . VAL   A 1 117 ? 16.46400  -11.68600 -18.12900 1.000 22.09789 ? 313 VAL   A CA  1 
ATOM   776  C C   . VAL   A 1 117 ? 16.38000  -12.45700 -19.44000 1.000 24.37350 ? 313 VAL   A C   1 
ATOM   777  O O   . VAL   A 1 117 ? 15.48500  -12.20300 -20.24500 1.000 22.64391 ? 313 VAL   A O   1 
ATOM   778  C CB  . VAL   A 1 117 ? 17.42700  -10.48600 -18.25200 1.000 20.79228 ? 313 VAL   A CB  1 
ATOM   779  C CG1 . VAL   A 1 117 ? 17.14400  -9.45900  -17.16200 1.000 28.14601 ? 313 VAL   A CG1 1 
ATOM   780  C CG2 . VAL   A 1 117 ? 18.92200  -10.90800 -18.30100 1.000 21.56652 ? 313 VAL   A CG2 1 
ATOM   781  N N   . TYR   A 1 118 ? 17.30500  -13.38600 -19.70800 1.000 20.56806 ? 314 TYR   A N   1 
ATOM   782  C CA  . TYR   A 1 118 ? 17.26200  -13.98300 -21.04100 1.000 22.31104 ? 314 TYR   A CA  1 
ATOM   783  C C   . TYR   A 1 118 ? 16.14100  -15.00300 -21.19300 1.000 18.79670 ? 314 TYR   A C   1 
ATOM   784  O O   . TYR   A 1 118 ? 15.63900  -15.18900 -22.30800 1.000 19.04319 ? 314 TYR   A O   1 
ATOM   785  C CB  . TYR   A 1 118 ? 18.62700  -14.59300 -21.39400 1.000 22.51745 ? 314 TYR   A CB  1 
ATOM   786  C CG  . TYR   A 1 118 ? 19.49900  -13.59000 -22.07700 1.000 22.40365 ? 314 TYR   A CG  1 
ATOM   787  C CD1 . TYR   A 1 118 ? 19.22800  -13.16700 -23.37200 1.000 22.92091 ? 314 TYR   A CD1 1 
ATOM   788  C CD2 . TYR   A 1 118 ? 20.55400  -12.99600 -21.39600 1.000 25.13344 ? 314 TYR   A CD2 1 
ATOM   789  C CE1 . TYR   A 1 118 ? 20.02400  -12.21500 -24.00000 1.000 22.46273 ? 314 TYR   A CE1 1 
ATOM   790  C CE2 . TYR   A 1 118 ? 21.35700  -12.05000 -22.01700 1.000 24.57319 ? 314 TYR   A CE2 1 
ATOM   791  C CZ  . TYR   A 1 118 ? 21.09300  -11.66700 -23.31000 1.000 25.85500 ? 314 TYR   A CZ  1 
ATOM   792  O OH  . TYR   A 1 118 ? 21.87800  -10.72200 -23.95100 1.000 24.42442 ? 314 TYR   A OH  1 
ATOM   793  N N   . GLU   A 1 119 ? 15.74100  -15.66400 -20.10600 1.000 18.69073 ? 315 GLU   A N   1 
ATOM   794  C CA  . GLU   A 1 119 ? 14.53100  -16.48700 -20.16200 1.000 17.03764 ? 315 GLU   A CA  1 
ATOM   795  C C   . GLU   A 1 119 ? 13.32500  -15.63100 -20.49900 1.000 17.82468 ? 315 GLU   A C   1 
ATOM   796  O O   . GLU   A 1 119 ? 12.50800  -16.00300 -21.35300 1.000 18.54116 ? 315 GLU   A O   1 
ATOM   797  C CB  . GLU   A 1 119 ? 14.30500  -17.19200 -18.83600 1.000 19.32897 ? 315 GLU   A CB  1 
ATOM   798  C CG  . GLU   A 1 119 ? 15.31400  -18.31100 -18.57800 1.000 20.10901 ? 315 GLU   A CG  1 
ATOM   799  C CD  . GLU   A 1 119 ? 15.18200  -18.87300 -17.16500 1.000 24.82743 ? 315 GLU   A CD  1 
ATOM   800  O OE1 . GLU   A 1 119 ? 14.09200  -18.73700 -16.55300 1.000 25.21060 ? 315 GLU   A OE1 1 
ATOM   801  O OE2 . GLU   A 1 119 ? 16.16200  -19.48400 -16.67000 1.000 26.60105 ? 315 GLU   A OE2 1 
ATOM   802  N N   . ALA   A 1 120 ? 13.24400  -14.45400 -19.88100 1.000 18.61284 ? 316 ALA   A N   1 
ATOM   803  C CA  . ALA   A 1 120 ? 12.17500  -13.51000 -20.18800 1.000 19.89019 ? 316 ALA   A CA  1 
ATOM   804  C C   . ALA   A 1 120 ? 12.28400  -12.97600 -21.61800 1.000 20.94351 ? 316 ALA   A C   1 
ATOM   805  O O   . ALA   A 1 120 ? 11.26200  -12.84800 -22.31300 1.000 20.52846 ? 316 ALA   A O   1 
ATOM   806  C CB  . ALA   A 1 120 ? 12.21800  -12.34100 -19.19300 1.000 20.82187 ? 316 ALA   A CB  1 
ATOM   807  N N   . ILE   A 1 121 ? 13.50000  -12.62700 -22.05900 1.000 19.67282 ? 317 ILE   A N   1 
ATOM   808  C CA  . ILE   A 1 121 ? 13.69700  -12.10800 -23.41200 1.000 19.04100 ? 317 ILE   A CA  1 
ATOM   809  C C   . ILE   A 1 121 ? 13.19500  -13.11500 -24.44400 1.000 22.50885 ? 317 ILE   A C   1 
ATOM   810  O O   . ILE   A 1 121 ? 12.45600  -12.76300 -25.36500 1.000 21.04482 ? 317 ILE   A O   1 
ATOM   811  C CB  . ILE   A 1 121 ? 15.18100  -11.75200 -23.64900 1.000 20.78015 ? 317 ILE   A CB  1 
ATOM   812  C CG1 . ILE   A 1 121 ? 15.48200  -10.42700 -22.94400 1.000 22.18786 ? 317 ILE   A CG1 1 
ATOM   813  C CG2 . ILE   A 1 121 ? 15.50500  -11.68100 -25.18000 1.000 25.09357 ? 317 ILE   A CG2 1 
ATOM   814  C CD1 . ILE   A 1 121 ? 16.95700  -10.04500 -22.96000 1.000 25.38497 ? 317 ILE   A CD1 1 
ATOM   815  N N   . PHE   A 1 122 ? 13.58500  -14.38600 -24.30600 1.000 19.91087 ? 318 PHE   A N   1 
ATOM   816  C CA  . PHE   A 1 122 ? 13.17800  -15.33700 -25.34000 1.000 20.33694 ? 318 PHE   A CA  1 
ATOM   817  C C   . PHE   A 1 122 ? 11.68700  -15.64900 -25.25500 1.000 20.78681 ? 318 PHE   A C   1 
ATOM   818  O O   . PHE   A 1 122 ? 11.05600  -15.85600 -26.29400 1.000 21.66025 ? 318 PHE   A O   1 
ATOM   819  C CB  . PHE   A 1 122 ? 14.03300  -16.60500 -25.26100 1.000 19.79853 ? 318 PHE   A CB  1 
ATOM   820  C CG  . PHE   A 1 122 ? 15.48800  -16.35700 -25.53500 1.000 24.73314 ? 318 PHE   A CG  1 
ATOM   821  C CD1 . PHE   A 1 122 ? 15.87300  -15.36400 -26.40400 1.000 27.77824 ? 318 PHE   A CD1 1 
ATOM   822  C CD2 . PHE   A 1 122 ? 16.45700  -17.11100 -24.88800 1.000 24.59436 ? 318 PHE   A CD2 1 
ATOM   823  C CE1 . PHE   A 1 122 ? 17.22900  -15.11500 -26.64900 1.000 29.62537 ? 318 PHE   A CE1 1 
ATOM   824  C CE2 . PHE   A 1 122 ? 17.84900  -16.86800 -25.13800 1.000 24.66582 ? 318 PHE   A CE2 1 
ATOM   825  C CZ  . PHE   A 1 122 ? 18.20200  -15.86800 -26.00000 1.000 24.19526 ? 318 PHE   A CZ  1 
ATOM   826  N N   . ALA   A 1 123 ? 11.09000  -15.61800 -24.05200 1.000 18.42145 ? 319 ALA   A N   1 
ATOM   827  C CA  . ALA   A 1 123 ? 9.63000   -15.76300 -23.97700 1.000 18.37809 ? 319 ALA   A CA  1 
ATOM   828  C C   . ALA   A 1 123 ? 8.92700   -14.61500 -24.69900 1.000 20.74173 ? 319 ALA   A C   1 
ATOM   829  O O   . ALA   A 1 123 ? 7.98000   -14.83700 -25.46500 1.000 20.39903 ? 319 ALA   A O   1 
ATOM   830  C CB  . ALA   A 1 123 ? 9.17000   -15.83900 -22.50900 1.000 20.79244 ? 319 ALA   A CB  1 
ATOM   831  N N   . MET   A 1 124 ? 9.37400   -13.37100 -24.45500 1.000 18.50604 ? 320 MET   A N   1 
ATOM   832  C CA  . MET   A 1 124 ? 8.75000   -12.19500 -25.05600 1.000 21.87127 ? 320 MET   A CA  1 
ATOM   833  C C   . MET   A 1 124 ? 9.07200   -12.03300 -26.54100 1.000 21.21322 ? 320 MET   A C   1 
ATOM   834  O O   . MET   A 1 124 ? 8.28000   -11.44500 -27.28900 1.000 18.63581 ? 320 MET   A O   1 
ATOM   835  C CB  . MET   A 1 124 ? 9.16000   -10.94000 -24.27600 1.000 18.61497 ? 320 MET   A CB  1 
ATOM   836  C CG  . MET   A 1 124 ? 8.51100   -10.89100 -22.88000 1.000 23.78874 ? 320 MET   A CG  1 
ATOM   837  S SD  . MET   A 1 124 ? 8.99200   -9.36200  -21.99300 1.000 26.44388 ? 320 MET   A SD  1 
ATOM   838  C CE  . MET   A 1 124 ? 10.78000  -9.45200  -22.06700 1.000 31.37808 ? 320 MET   A CE  1 
ATOM   839  N N   . LEU   A 1 125 ? 10.22300  -12.54200 -26.99600 1.000 20.14661 ? 321 LEU   A N   1 
ATOM   840  C CA  . LEU   A 1 125 ? 10.49500  -12.56500 -28.43300 1.000 20.08809 ? 321 LEU   A CA  1 
ATOM   841  C C   . LEU   A 1 125 ? 9.38500   -13.26100 -29.20900 1.000 18.50967 ? 321 LEU   A C   1 
ATOM   842  O O   . LEU   A 1 125 ? 9.11200   -12.90700 -30.37100 1.000 18.95179 ? 321 LEU   A O   1 
ATOM   843  C CB  . LEU   A 1 125 ? 11.83400  -13.27100 -28.69000 1.000 26.46014 ? 321 LEU   A CB  1 
ATOM   844  C CG  . LEU   A 1 125 ? 13.08500  -12.42300 -28.89000 1.000 33.33623 ? 321 LEU   A CG  1 
ATOM   845  C CD1 . LEU   A 1 125 ? 14.05600  -13.26900 -29.68300 1.000 30.31813 ? 321 LEU   A CD1 1 
ATOM   846  C CD2 . LEU   A 1 125 ? 12.77200  -11.12600 -29.60300 1.000 29.17066 ? 321 LEU   A CD2 1 
ATOM   847  N N   . SER   A 1 126 ? 8.73200   -14.25600 -28.59800 1.000 19.70087 ? 322 SER   A N   1 
ATOM   848  C CA  . SER   A 1 126 ? 7.68300   -14.97900 -29.29500 1.000 18.93937 ? 322 SER   A CA  1 
ATOM   849  C C   . SER   A 1 126 ? 6.57400   -14.04200 -29.74200 1.000 18.07319 ? 322 SER   A C   1 
ATOM   850  O O   . SER   A 1 126 ? 5.99600   -14.24000 -30.81400 1.000 20.13081 ? 322 SER   A O   1 
ATOM   851  C CB  . SER   A 1 126 ? 7.10100   -16.08800 -28.41100 1.000 21.04038 ? 322 SER   A CB  1 
ATOM   852  O OG  . SER   A 1 126 ? 8.15900   -16.85500 -27.86500 1.000 23.36867 ? 322 SER   A OG  1 
ATOM   853  N N   . SER   A 1 127 ? 6.31000   -12.98600 -28.96300 1.000 18.82708 ? 323 SER   A N   1 
ATOM   854  C CA  . SER   A 1 127 ? 5.25000   -12.04200 -29.32000 1.000 19.05580 ? 323 SER   A CA  1 
ATOM   855  C C   . SER   A 1 127 ? 5.52700   -11.30000 -30.62200 1.000 20.16234 ? 323 SER   A C   1 
ATOM   856  O O   . SER   A 1 127 ? 4.58200   -10.81000 -31.24500 1.000 21.29048 ? 323 SER   A O   1 
ATOM   857  C CB  . SER   A 1 127 ? 5.08900   -11.01200 -28.20000 1.000 20.07617 ? 323 SER   A CB  1 
ATOM   858  O OG  . SER   A 1 127 ? 4.73400   -11.63700 -26.97300 1.000 20.37425 ? 323 SER   A OG  1 
ATOM   859  N N   . VAL   A 1 128 ? 6.78800   -11.20000 -31.06200 1.000 18.77635 ? 324 VAL   A N   1 
ATOM   860  C CA  . VAL   A 1 128 ? 7.13100   -10.47100 -32.27600 1.000 18.07208 ? 324 VAL   A CA  1 
ATOM   861  C C   . VAL   A 1 128 ? 7.56900   -11.41200 -33.39700 1.000 19.64624 ? 324 VAL   A C   1 
ATOM   862  O O   . VAL   A 1 128 ? 8.02900   -10.94800 -34.44900 1.000 21.42094 ? 324 VAL   A O   1 
ATOM   863  C CB  . VAL   A 1 128 ? 8.20900   -9.39600  -32.02000 1.000 18.73001 ? 324 VAL   A CB  1 
ATOM   864  C CG1 . VAL   A 1 128 ? 7.69500   -8.32600  -31.03200 1.000 21.76951 ? 324 VAL   A CG1 1 
ATOM   865  C CG2 . VAL   A 1 128 ? 9.55100   -9.99500  -31.48700 1.000 20.72896 ? 324 VAL   A CG2 1 
ATOM   866  N N   . MET   A 1 129 ? 7.41100   -12.71700 -33.20500 1.000 17.95151 ? 325 MET   A N   1 
ATOM   867  C CA  . MET   A 1 129 ? 7.82600   -13.73000 -34.16900 1.000 18.66140 ? 325 MET   A CA  1 
ATOM   868  C C   . MET   A 1 129 ? 6.59600   -14.36500 -34.79500 1.000 21.05289 ? 325 MET   A C   1 
ATOM   869  O O   . MET   A 1 129 ? 5.61800   -14.63600 -34.10600 1.000 22.36441 ? 325 MET   A O   1 
ATOM   870  C CB  . MET   A 1 129 ? 8.63600   -14.79700 -33.44800 1.000 20.92908 ? 325 MET   A CB  1 
ATOM   871  C CG  . MET   A 1 129 ? 10.03900  -14.31200 -33.12400 1.000 19.21217 ? 325 MET   A CG  1 
ATOM   872  S SD  . MET   A 1 129 ? 10.87600  -15.68900 -32.28000 1.000 24.13985 ? 325 MET   A SD  1 
ATOM   873  C CE  . MET   A 1 129 ? 12.59400  -15.34100 -32.69700 1.000 24.56323 ? 325 MET   A CE  1 
ATOM   874  N N   . ASN   A 1 130 ? 6.67000   -14.60500 -36.10900 1.000 21.84425 ? 326 ASN   A N   1 
ATOM   875  C CA  . ASN   A 1 130 ? 5.77100   -15.56700 -36.73400 1.000 22.24414 ? 326 ASN   A CA  1 
ATOM   876  C C   . ASN   A 1 130 ? 6.60000   -16.59500 -37.50800 1.000 23.32904 ? 326 ASN   A C   1 
ATOM   877  O O   . ASN   A 1 130 ? 7.83300   -16.59200 -37.42900 1.000 20.33865 ? 326 ASN   A O   1 
ATOM   878  C CB  . ASN   A 1 130 ? 4.71900   -14.86000 -37.59600 1.000 24.79033 ? 326 ASN   A CB  1 
ATOM   879  C CG  . ASN   A 1 130 ? 5.29500   -14.08800 -38.79600 1.000 23.60918 ? 326 ASN   A CG  1 
ATOM   880  O OD1 . ASN   A 1 130 ? 6.37300   -14.38100 -39.31500 1.000 22.33197 ? 326 ASN   A OD1 1 
ATOM   881  N ND2 . ASN   A 1 130 ? 4.55200   -13.08000 -39.23900 1.000 26.97974 ? 326 ASN   A ND2 1 
ATOM   882  N N   . LYS   A 1 131 ? 5.93500   -17.48500 -38.24500 1.000 24.66336 ? 327 LYS   A N   1 
ATOM   883  C CA  . LYS   A 1 131 ? 6.63900   -18.54900 -38.94600 1.000 25.68934 ? 327 LYS   A CA  1 
ATOM   884  C C   . LYS   A 1 131 ? 7.62000   -18.01800 -39.98500 1.000 25.32161 ? 327 LYS   A C   1 
ATOM   885  O O   . LYS   A 1 131 ? 8.54000   -18.74600 -40.38100 1.000 29.81482 ? 327 LYS   A O   1 
ATOM   886  C CB  . LYS   A 1 131 ? 5.60300   -19.48800 -39.57100 1.000 32.25833 ? 327 LYS   A CB  1 
ATOM   887  C CG  . LYS   A 1 131 ? 5.45500   -19.35300 -41.07000 1.000 38.80275 ? 327 LYS   A CG  1 
ATOM   888  C CD  . LYS   A 1 131 ? 4.67400   -20.51400 -41.68300 1.000 53.94623 ? 327 LYS   A CD  1 
ATOM   889  C CE  . LYS   A 1 131 ? 5.09600   -20.76100 -43.14400 1.000 47.51614 ? 327 LYS   A CE  1 
ATOM   890  N NZ  . LYS   A 1 131 ? 6.45000   -21.39100 -43.26600 1.000 54.31623 ? 327 LYS   A NZ  1 
ATOM   891  N N   . ASP   A 1 132 ? 7.46400   -16.77000 -40.41500 1.000 23.18778 ? 328 ASP   A N   1 
ATOM   892  C CA  . ASP   A 1 132 ? 8.29800   -16.24400 -41.48500 1.000 23.35944 ? 328 ASP   A CA  1 
ATOM   893  C C   . ASP   A 1 132 ? 9.40400   -15.30300 -41.01000 1.000 22.72378 ? 328 ASP   A C   1 
ATOM   894  O O   . ASP   A 1 132 ? 10.28900  -14.97800 -41.80700 1.000 23.33760 ? 328 ASP   A O   1 
ATOM   895  C CB  . ASP   A 1 132 ? 7.45000   -15.48500 -42.51600 1.000 28.03519 ? 328 ASP   A CB  1 
ATOM   896  C CG  . ASP   A 1 132 ? 6.42800   -16.36600 -43.20000 1.000 34.54761 ? 328 ASP   A CG  1 
ATOM   897  O OD1 . ASP   A 1 132 ? 6.70500   -17.56800 -43.39100 1.000 40.70724 ? 328 ASP   A OD1 1 
ATOM   898  O OD2 . ASP   A 1 132 ? 5.35800   -15.83600 -43.55000 1.000 42.28623 ? 328 ASP   A OD2 1 
ATOM   899  N N   . GLY   A 1 133 ? 9.38200   -14.82900 -39.76800 1.000 21.29270 ? 329 GLY   A N   1 
ATOM   900  C CA  . GLY   A 1 133 ? 10.39700  -13.87100 -39.38300 1.000 19.49013 ? 329 GLY   A CA  1 
ATOM   901  C C   . GLY   A 1 133 ? 10.01400  -13.16400 -38.09800 1.000 18.58178 ? 329 GLY   A C   1 
ATOM   902  O O   . GLY   A 1 133 ? 9.13000   -13.61800 -37.37400 1.000 18.90121 ? 329 GLY   A O   1 
ATOM   903  N N   . MET   A 1 134 ? 10.72100  -12.07400 -37.82700 1.000 19.54722 ? 330 MET   A N   1 
ATOM   904  C CA  . MET   A 1 134 ? 10.52900  -11.35300 -36.57400 1.000 19.69215 ? 330 MET   A CA  1 
ATOM   905  C C   . MET   A 1 134 ? 10.62900  -9.83200  -36.75500 1.000 21.35194 ? 330 MET   A C   1 
ATOM   906  O O   . MET   A 1 134 ? 11.41800  -9.32700  -37.57500 1.000 20.14223 ? 330 MET   A O   1 
ATOM   907  C CB  . MET   A 1 134 ? 11.51700  -11.85600 -35.54800 1.000 23.33940 ? 330 MET   A CB  1 
ATOM   908  C CG  . MET   A 1 134 ? 12.80500  -11.30200 -35.72100 1.000 23.34746 ? 330 MET   A CG  1 
ATOM   909  S SD  . MET   A 1 134 ? 13.79300  -12.32300 -34.63500 1.000 33.53643 ? 330 MET   A SD  1 
ATOM   910  C CE  . MET   A 1 134 ? 13.70000  -11.23000 -33.28200 1.000 15.84828 ? 330 MET   A CE  1 
ATOM   911  N N   . LEU   A 1 135 ? 9.77700   -9.12800  -35.99200 1.000 19.10203 ? 331 LEU   A N   1 
ATOM   912  C CA  . LEU   A 1 135 ? 9.80700   -7.67500  -35.92500 1.000 18.21173 ? 331 LEU   A CA  1 
ATOM   913  C C   . LEU   A 1 135 ? 11.06300  -7.22000  -35.21500 1.000 22.44224 ? 331 LEU   A C   1 
ATOM   914  O O   . LEU   A 1 135 ? 11.45700  -7.79800  -34.19800 1.000 27.34423 ? 331 LEU   A O   1 
ATOM   915  C CB  . LEU   A 1 135 ? 8.60000   -7.14400  -35.15600 1.000 23.98714 ? 331 LEU   A CB  1 
ATOM   916  C CG  . LEU   A 1 135 ? 7.30000   -6.93000  -35.87000 1.000 27.11782 ? 331 LEU   A CG  1 
ATOM   917  C CD1 . LEU   A 1 135 ? 6.33700   -6.33300  -34.83200 1.000 24.83252 ? 331 LEU   A CD1 1 
ATOM   918  C CD2 . LEU   A 1 135 ? 7.44800   -6.00900  -37.12200 1.000 24.85287 ? 331 LEU   A CD2 1 
ATOM   919  N N   . VAL   A 1 136 ? 11.69800  -6.18300  -35.75500 1.000 19.08347 ? 332 VAL   A N   1 
ATOM   920  C CA  . VAL   A 1 136 ? 12.93400  -5.63600  -35.18900 1.000 19.57924 ? 332 VAL   A CA  1 
ATOM   921  C C   . VAL   A 1 136 ? 12.86600  -4.10700  -35.19800 1.000 21.81892 ? 332 VAL   A C   1 
ATOM   922  O O   . VAL   A 1 136 ? 12.03800  -3.50400  -35.87200 1.000 21.34943 ? 332 VAL   A O   1 
ATOM   923  C CB  . VAL   A 1 136 ? 14.20000  -6.12900  -35.93900 1.000 25.35062 ? 332 VAL   A CB  1 
ATOM   924  C CG1 . VAL   A 1 136 ? 14.38000  -7.65300  -35.75000 1.000 25.88935 ? 332 VAL   A CG1 1 
ATOM   925  C CG2 . VAL   A 1 136 ? 14.15900  -5.76500  -37.44200 1.000 22.90145 ? 332 VAL   A CG2 1 
ATOM   926  N N   . ALA   A 1 137 ? 13.80200  -3.47900  -34.48600 1.000 20.85414 ? 333 ALA   A N   1 
ATOM   927  C CA  . ALA   A 1 137 ? 14.01200  -2.02700  -34.55500 1.000 23.49805 ? 333 ALA   A CA  1 
ATOM   928  C C   . ALA   A 1 137 ? 12.72500  -1.26200  -34.23300 1.000 22.89861 ? 333 ALA   A C   1 
ATOM   929  O O   . ALA   A 1 137 ? 12.24200  -0.43200  -35.00900 1.000 21.39682 ? 333 ALA   A O   1 
ATOM   930  C CB  . ALA   A 1 137 ? 14.58200  -1.61800  -35.92600 1.000 22.78791 ? 333 ALA   A CB  1 
ATOM   931  N N   . TYR   A 1 138 ? 12.19600  -1.54100  -33.03100 1.000 21.64649 ? 334 TYR   A N   1 
ATOM   932  C CA  . TYR   A 1 138 ? 11.04900  -0.82400  -32.46700 1.000 23.45305 ? 334 TYR   A CA  1 
ATOM   933  C C   . TYR   A 1 138 ? 9.86000   -0.88700  -33.41800 1.000 22.40369 ? 334 TYR   A C   1 
ATOM   934  O O   . TYR   A 1 138 ? 9.13000   0.08400   -33.60500 1.000 23.32277 ? 334 TYR   A O   1 
ATOM   935  C CB  . TYR   A 1 138 ? 11.43500  0.61800   -32.10100 1.000 19.44987 ? 334 TYR   A CB  1 
ATOM   936  C CG  . TYR   A 1 138 ? 12.49300  0.61100   -31.03000 1.000 20.26821 ? 334 TYR   A CG  1 
ATOM   937  C CD1 . TYR   A 1 138 ? 12.12300  0.64200   -29.68600 1.000 23.61516 ? 334 TYR   A CD1 1 
ATOM   938  C CD2 . TYR   A 1 138 ? 13.82900  0.52200   -31.35000 1.000 23.32375 ? 334 TYR   A CD2 1 
ATOM   939  C CE1 . TYR   A 1 138 ? 13.06700  0.59200   -28.69600 1.000 25.05270 ? 334 TYR   A CE1 1 
ATOM   940  C CE2 . TYR   A 1 138 ? 14.78300  0.47000   -30.35600 1.000 28.90671 ? 334 TYR   A CE2 1 
ATOM   941  C CZ  . TYR   A 1 138 ? 14.39100  0.51500   -29.04400 1.000 26.25278 ? 334 TYR   A CZ  1 
ATOM   942  O OH  . TYR   A 1 138 ? 15.34900  0.46100   -28.04000 1.000 36.43759 ? 334 TYR   A OH  1 
ATOM   943  N N   . GLY   A 1 139 ? 9.67600   -2.05800  -34.02500 1.000 21.93028 ? 335 GLY   A N   1 
ATOM   944  C CA  . GLY   A 1 139 ? 8.56800   -2.31800  -34.92000 1.000 22.36976 ? 335 GLY   A CA  1 
ATOM   945  C C   . GLY   A 1 139 ? 8.72500   -1.81200  -36.34100 1.000 21.96217 ? 335 GLY   A C   1 
ATOM   946  O O   . GLY   A 1 139 ? 7.77300   -1.93100  -37.13100 1.000 25.35155 ? 335 GLY   A O   1 
ATOM   947  N N   . ASN   A 1 140 ? 9.88100   -1.25800  -36.71200 1.000 22.22137 ? 336 ASN   A N   1 
ATOM   948  C CA  . ASN   A 1 140 ? 10.03400  -0.64900  -38.03400 1.000 22.62523 ? 336 ASN   A CA  1 
ATOM   949  C C   . ASN   A 1 140 ? 10.66400  -1.56500  -39.06400 1.000 23.38746 ? 336 ASN   A C   1 
ATOM   950  O O   . ASN   A 1 140 ? 10.68300  -1.21700  -40.25300 1.000 25.39954 ? 336 ASN   A O   1 
ATOM   951  C CB  . ASN   A 1 140 ? 10.86600  0.62900   -37.92500 1.000 24.32090 ? 336 ASN   A CB  1 
ATOM   952  C CG  . ASN   A 1 140 ? 10.14100  1.67900   -37.12500 1.000 25.04292 ? 336 ASN   A CG  1 
ATOM   953  O OD1 . ASN   A 1 140 ? 9.15800   2.25300   -37.60500 1.000 30.79435 ? 336 ASN   A OD1 1 
ATOM   954  N ND2 . ASN   A 1 140 ? 10.55100  1.86600   -35.86700 1.000 25.70593 ? 336 ASN   A ND2 1 
ATOM   955  N N   . GLY   A 1 141 ? 11.14000  -2.73700  -38.65200 1.000 21.53370 ? 337 GLY   A N   1 
ATOM   956  C CA  . GLY   A 1 141 ? 11.76300  -3.66900  -39.56200 1.000 23.75670 ? 337 GLY   A CA  1 
ATOM   957  C C   . GLY   A 1 141 ? 11.22500  -5.06000  -39.31100 1.000 20.35836 ? 337 GLY   A C   1 
ATOM   958  O O   . GLY   A 1 141 ? 10.65700  -5.34900  -38.25900 1.000 18.71012 ? 337 GLY   A O   1 
ATOM   959  N N   . PHE   A 1 142 ? 11.35800  -5.91800  -40.31900 1.000 20.38205 ? 338 PHE   A N   1 
ATOM   960  C CA  . PHE   A 1 142 ? 10.96000  -7.31400  -40.19000 1.000 21.34216 ? 338 PHE   A CA  1 
ATOM   961  C C   . PHE   A 1 142 ? 12.04900  -8.12500  -40.86500 1.000 22.77024 ? 338 PHE   A C   1 
ATOM   962  O O   . PHE   A 1 142 ? 12.23000  -8.00200  -42.08000 1.000 23.82754 ? 338 PHE   A O   1 
ATOM   963  C CB  . PHE   A 1 142 ? 9.58800   -7.57300  -40.81500 1.000 20.78567 ? 338 PHE   A CB  1 
ATOM   964  C CG  . PHE   A 1 142 ? 9.12200   -9.00500  -40.74800 1.000 21.17059 ? 338 PHE   A CG  1 
ATOM   965  C CD1 . PHE   A 1 142 ? 8.43000   -9.47900  -39.63600 1.000 22.02362 ? 338 PHE   A CD1 1 
ATOM   966  C CD2 . PHE   A 1 142 ? 9.34800   -9.87400  -41.81600 1.000 24.03462 ? 338 PHE   A CD2 1 
ATOM   967  C CE1 . PHE   A 1 142 ? 7.99700   -10.77900 -39.58600 1.000 21.46653 ? 338 PHE   A CE1 1 
ATOM   968  C CE2 . PHE   A 1 142 ? 8.90000   -11.19200 -41.75900 1.000 24.43514 ? 338 PHE   A CE2 1 
ATOM   969  C CZ  . PHE   A 1 142 ? 8.22600   -11.63200 -40.66100 1.000 23.46862 ? 338 PHE   A CZ  1 
ATOM   970  N N   . ILE   A 1 143 ? 12.74300  -8.95700  -40.11700 1.000 19.79606 ? 339 ILE   A N   1 
ATOM   971  C CA  . ILE   A 1 143 ? 13.83600  -9.74500  -40.69500 1.000 21.58384 ? 339 ILE   A CA  1 
ATOM   972  C C   . ILE   A 1 143 ? 13.37700  -11.19000 -40.84300 1.000 22.76417 ? 339 ILE   A C   1 
ATOM   973  O O   . ILE   A 1 143 ? 12.78800  -11.76700 -39.91500 1.000 19.87533 ? 339 ILE   A O   1 
ATOM   974  C CB  . ILE   A 1 143 ? 15.12700  -9.62200  -39.86000 1.000 22.48656 ? 339 ILE   A CB  1 
ATOM   975  C CG1 . ILE   A 1 143 ? 16.31600  -10.27300 -40.58300 1.000 20.68510 ? 339 ILE   A CG1 1 
ATOM   976  C CG2 . ILE   A 1 143 ? 15.02100  -10.23300 -38.47300 1.000 22.82629 ? 339 ILE   A CG2 1 
ATOM   977  C CD1 . ILE   A 1 143 ? 17.63500  -9.76300  -40.04700 1.000 22.79200 ? 339 ILE   A CD1 1 
ATOM   978  N N   . THR   A 1 144 ? 13.61700  -11.77800 -42.02500 1.000 21.91113 ? 340 THR   A N   1 
ATOM   979  C CA  . THR   A 1 144 ? 13.03600  -13.08700 -42.27700 1.000 22.45720 ? 340 THR   A CA  1 
ATOM   980  C C   . THR   A 1 144 ? 13.86200  -14.21400 -41.68400 1.000 20.61658 ? 340 THR   A C   1 
ATOM   981  O O   . THR   A 1 144 ? 15.08400  -14.13600 -41.53600 1.000 20.73436 ? 340 THR   A O   1 
ATOM   982  C CB  . THR   A 1 144 ? 12.81600  -13.37200 -43.77300 1.000 23.50535 ? 340 THR   A CB  1 
ATOM   983  O OG1 . THR   A 1 144 ? 14.07400  -13.54300 -44.43100 1.000 25.81224 ? 340 THR   A OG1 1 
ATOM   984  C CG2 . THR   A 1 144 ? 12.01900  -12.25500 -44.42700 1.000 25.98387 ? 340 THR   A CG2 1 
ATOM   985  N N   . ARG   A 1 145 ? 13.12500  -15.26000 -41.31500 1.000 22.27481 ? 341 ARG   A N   1 
ATOM   986  C CA  . ARG   A 1 145 ? 13.71400  -16.46300 -40.76600 1.000 19.32760 ? 341 ARG   A CA  1 
ATOM   987  C C   . ARG   A 1 145 ? 14.65100  -17.10500 -41.77900 1.000 23.15412 ? 341 ARG   A C   1 
ATOM   988  O O   . ARG   A 1 145 ? 15.74700  -17.56400 -41.41700 1.000 23.76329 ? 341 ARG   A O   1 
ATOM   989  C CB  . ARG   A 1 145 ? 12.56500  -17.37800 -40.34000 1.000 23.30292 ? 341 ARG   A CB  1 
ATOM   990  C CG  . ARG   A 1 145 ? 12.98100  -18.65900 -39.70500 1.000 23.61682 ? 341 ARG   A CG  1 
ATOM   991  C CD  . ARG   A 1 145 ? 11.72600  -19.42300 -39.34900 1.000 25.36223 ? 341 ARG   A CD  1 
ATOM   992  N NE  . ARG   A 1 145 ? 12.02200  -20.57600 -38.51900 1.000 26.48478 ? 341 ARG   A NE  1 
ATOM   993  C CZ  . ARG   A 1 145 ? 11.07300  -21.35400 -38.02200 1.000 28.11079 ? 341 ARG   A CZ  1 
ATOM   994  N NH1 . ARG   A 1 145 ? 9.79400   -21.09500 -38.23800 1.000 31.21851 ? 341 ARG   A NH1 1 
ATOM   995  N NH2 . ARG   A 1 145 ? 11.41600  -22.40100 -37.28600 1.000 31.35756 ? 341 ARG   A NH2 1 
ATOM   996  N N   . GLU   A 1 146 ? 14.26400  -17.08000 -43.05900 1.000 24.06899 ? 342 GLU   A N   1 
ATOM   997  C CA  . GLU   A 1 146 ? 15.11600  -17.67700 -44.09400 1.000 24.89373 ? 342 GLU   A CA  1 
ATOM   998  C C   . GLU   A 1 146 ? 16.39500  -16.88000 -44.29400 1.000 26.66444 ? 342 GLU   A C   1 
ATOM   999  O O   . GLU   A 1 146 ? 17.47300  -17.46400 -44.51900 1.000 27.02300 ? 342 GLU   A O   1 
ATOM   1000 C CB  . GLU   A 1 146 ? 14.33900  -17.79600 -45.41300 1.000 27.85750 ? 342 GLU   A CB  1 
ATOM   1001 C CG  . GLU   A 1 146 ? 13.35800  -18.96500 -45.44100 1.000 35.26649 ? 342 GLU   A CG  1 
ATOM   1002 C CD  . GLU   A 1 146 ? 14.01900  -20.29800 -45.11600 1.000 39.07623 ? 342 GLU   A CD  1 
ATOM   1003 O OE1 . GLU   A 1 146 ? 13.45000  -21.07300 -44.31800 1.000 41.46498 ? 342 GLU   A OE1 1 
ATOM   1004 O OE2 . GLU   A 1 146 ? 15.10500  -20.57800 -45.66900 1.000 41.29623 ? 342 GLU   A OE2 1 
ATOM   1005 N N   . PHE   A 1 147 ? 16.31600  -15.54400 -44.21900 1.000 23.11471 ? 343 PHE   A N   1 
ATOM   1006 C CA  . PHE   A 1 147 ? 17.53700  -14.76100 -44.34200 1.000 24.08760 ? 343 PHE   A CA  1 
ATOM   1007 C C   . PHE   A 1 147 ? 18.49800  -15.08200 -43.20400 1.000 23.18931 ? 343 PHE   A C   1 
ATOM   1008 O O   . PHE   A 1 147 ? 19.70800  -15.25600 -43.42300 1.000 26.03187 ? 343 PHE   A O   1 
ATOM   1009 C CB  . PHE   A 1 147 ? 17.19800  -13.26800 -44.41300 1.000 22.73636 ? 343 PHE   A CB  1 
ATOM   1010 C CG  . PHE   A 1 147 ? 18.40700  -12.37900 -44.45000 1.000 25.82946 ? 343 PHE   A CG  1 
ATOM   1011 C CD1 . PHE   A 1 147 ? 19.29400  -12.40600 -45.53300 1.000 24.89657 ? 343 PHE   A CD1 1 
ATOM   1012 C CD2 . PHE   A 1 147 ? 18.67500  -11.53600 -43.39300 1.000 23.87190 ? 343 PHE   A CD2 1 
ATOM   1013 C CE1 . PHE   A 1 147 ? 20.41100  -11.58600 -45.56700 1.000 27.26031 ? 343 PHE   A CE1 1 
ATOM   1014 C CE2 . PHE   A 1 147 ? 19.81700  -10.71300 -43.40200 1.000 23.91461 ? 343 PHE   A CE2 1 
ATOM   1015 C CZ  . PHE   A 1 147 ? 20.68700  -10.74100 -44.51300 1.000 26.62748 ? 343 PHE   A CZ  1 
ATOM   1016 N N   . LEU   A 1 148 ? 17.98000  -15.21800 -41.97900 1.000 22.00369 ? 344 LEU   A N   1 
ATOM   1017 C CA  . LEU   A 1 148 ? 18.83800  -15.52700 -40.83900 1.000 25.35622 ? 344 LEU   A CA  1 
ATOM   1018 C C   . LEU   A 1 148 ? 19.52600  -16.88200 -41.00600 1.000 24.75086 ? 344 LEU   A C   1 
ATOM   1019 O O   . LEU   A 1 148 ? 20.71900  -17.02800 -40.70700 1.000 25.69618 ? 344 LEU   A O   1 
ATOM   1020 C CB  . LEU   A 1 148 ? 17.99400  -15.48200 -39.55900 1.000 24.80821 ? 344 LEU   A CB  1 
ATOM   1021 C CG  . LEU   A 1 148 ? 17.64800  -14.04900 -39.13500 1.000 24.76778 ? 344 LEU   A CG  1 
ATOM   1022 C CD1 . LEU   A 1 148 ? 16.49000  -14.10300 -38.09200 1.000 23.43584 ? 344 LEU   A CD1 1 
ATOM   1023 C CD2 . LEU   A 1 148 ? 18.90800  -13.31100 -38.61300 1.000 26.51632 ? 344 LEU   A CD2 1 
ATOM   1024 N N   . LYS   A 1 149 ? 18.79400  -17.87400 -41.50200 1.000 25.19784 ? 345 LYS   A N   1 
ATOM   1025 C CA  . LYS   A 1 149 ? 19.38800  -19.17800 -41.78800 1.000 27.79735 ? 345 LYS   A CA  1 
ATOM   1026 C C   . LYS   A 1 149 ? 20.44400  -19.10700 -42.87900 1.000 28.43835 ? 345 LYS   A C   1 
ATOM   1027 O O   . LYS   A 1 149 ? 21.31100  -19.99000 -42.94400 1.000 33.09831 ? 345 LYS   A O   1 
ATOM   1028 C CB  . LYS   A 1 149 ? 18.30900  -20.16900 -42.21900 1.000 28.56506 ? 345 LYS   A CB  1 
ATOM   1029 C CG  . LYS   A 1 149 ? 17.56200  -20.80300 -41.05600 1.000 34.73623 ? 345 LYS   A CG  1 
ATOM   1030 C CD  . LYS   A 1 149 ? 16.23500  -21.39000 -41.49700 1.000 35.97849 ? 345 LYS   A CD  1 
ATOM   1031 C CE  . LYS   A 1 149 ? 16.44500  -22.66500 -42.28900 1.000 37.94292 ? 345 LYS   A CE  1 
ATOM   1032 N NZ  . LYS   A 1 149 ? 15.15400  -23.32600 -42.63200 1.000 38.98128 ? 345 LYS   A NZ  1 
ATOM   1033 N N   . SER   A 1 150 ? 20.39500  -18.08600 -43.73300 1.000 26.80532 ? 346 SER   A N   1 
ATOM   1034 C CA  . SER   A 1 150 ? 21.30800  -17.97000 -44.87300 1.000 28.75126 ? 346 SER   A CA  1 
ATOM   1035 C C   . SER   A 1 150 ? 22.68800  -17.45500 -44.49100 1.000 31.63212 ? 346 SER   A C   1 
ATOM   1036 O O   . SER   A 1 150 ? 23.61500  -17.53600 -45.31200 1.000 33.18654 ? 346 SER   A O   1 
ATOM   1037 C CB  . SER   A 1 150 ? 20.67100  -17.06100 -45.93400 1.000 30.85377 ? 346 SER   A CB  1 
ATOM   1038 O OG  . SER   A 1 150 ? 20.93900  -15.67300 -45.74800 1.000 27.75828 ? 346 SER   A OG  1 
ATOM   1039 N N   . LEU   A 1 151 ? 22.83800  -16.91700 -43.28300 1.000 25.54022 ? 347 LEU   A N   1 
ATOM   1040 C CA  . LEU   A 1 151 ? 24.08200  -16.32400 -42.84400 1.000 27.23244 ? 347 LEU   A CA  1 
ATOM   1041 C C   . LEU   A 1 151 ? 25.14000  -17.39900 -42.65100 1.000 25.64024 ? 347 LEU   A C   1 
ATOM   1042 O O   . LEU   A 1 151 ? 24.83700  -18.59000 -42.47900 1.000 29.70872 ? 347 LEU   A O   1 
ATOM   1043 C CB  . LEU   A 1 151 ? 23.87500  -15.56500 -41.53300 1.000 26.06860 ? 347 LEU   A CB  1 
ATOM   1044 C CG  . LEU   A 1 151 ? 22.77700  -14.49800 -41.65500 1.000 25.06965 ? 347 LEU   A CG  1 
ATOM   1045 C CD1 . LEU   A 1 151 ? 22.44700  -13.97600 -40.25500 1.000 28.51234 ? 347 LEU   A CD1 1 
ATOM   1046 C CD2 . LEU   A 1 151 ? 23.20000  -13.36000 -42.58600 1.000 27.51897 ? 347 LEU   A CD2 1 
ATOM   1047 N N   . ARG   A 1 152 ? 26.39400  -16.96200 -42.62700 1.000 28.72421 ? 348 ARG   A N   1 
ATOM   1048 C CA  . ARG   A 1 152 ? 27.46300  -17.90900 -42.35600 1.000 33.16095 ? 348 ARG   A CA  1 
ATOM   1049 C C   . ARG   A 1 152 ? 27.42900  -18.38700 -40.91000 1.000 32.56067 ? 348 ARG   A C   1 
ATOM   1050 O O   . ARG   A 1 152 ? 27.00900  -17.67300 -39.98300 1.000 29.61181 ? 348 ARG   A O   1 
ATOM   1051 C CB  . ARG   A 1 152 ? 28.83900  -17.30900 -42.67800 1.000 30.74471 ? 348 ARG   A CB  1 
ATOM   1052 C CG  . ARG   A 1 152 ? 29.43900  -16.31100 -41.66100 1.000 30.26243 ? 348 ARG   A CG  1 
ATOM   1053 C CD  . ARG   A 1 152 ? 30.98400  -16.25800 -41.83600 1.000 33.40843 ? 348 ARG   A CD  1 
ATOM   1054 N NE  . ARG   A 1 152 ? 31.61300  -15.16200 -41.11000 1.000 34.89984 ? 348 ARG   A NE  1 
ATOM   1055 C CZ  . ARG   A 1 152 ? 32.07400  -15.23100 -39.86600 1.000 32.60344 ? 348 ARG   A CZ  1 
ATOM   1056 N NH1 . ARG   A 1 152 ? 31.89600  -16.30800 -39.11700 1.000 35.79062 ? 348 ARG   A NH1 1 
ATOM   1057 N NH2 . ARG   A 1 152 ? 32.71900  -14.18500 -39.35300 1.000 38.62933 ? 348 ARG   A NH2 1 
ATOM   1058 N N   . LYS   A 1 153 ? 27.88000  -19.62300 -40.72600 1.000 34.00920 ? 349 LYS   A N   1 
ATOM   1059 C CA  . LYS   A 1 153 ? 28.09300  -20.15800 -39.39600 1.000 30.14281 ? 349 LYS   A CA  1 
ATOM   1060 C C   . LYS   A 1 153 ? 29.10800  -19.28600 -38.65800 1.000 34.35972 ? 349 LYS   A C   1 
ATOM   1061 O O   . LYS   A 1 153 ? 30.04800  -18.77600 -39.26400 1.000 34.34759 ? 349 LYS   A O   1 
ATOM   1062 C CB  . LYS   A 1 153 ? 28.61000  -21.59800 -39.48600 1.000 34.05864 ? 349 LYS   A CB  1 
ATOM   1063 C CG  . LYS   A 1 153 ? 27.53200  -22.62400 -39.71900 1.000 37.70415 ? 349 LYS   A CG  1 
ATOM   1064 C CD  . LYS   A 1 153 ? 28.06400  -24.04900 -39.66300 1.000 46.84623 ? 349 LYS   A CD  1 
ATOM   1065 C CE  . LYS   A 1 153 ? 26.95000  -25.00800 -39.26500 1.000 48.27241 ? 349 LYS   A CE  1 
ATOM   1066 N NZ  . LYS   A 1 153 ? 26.95900  -25.27800 -37.80200 1.000 46.02240 ? 349 LYS   A NZ  1 
ATOM   1067 N N   . PRO   A 1 154 ? 28.94100  -19.08400 -37.34900 1.000 29.45505 ? 350 PRO   A N   1 
ATOM   1068 C CA  . PRO   A 1 154 ? 27.89100  -19.69800 -36.53300 1.000 32.34875 ? 350 PRO   A CA  1 
ATOM   1069 C C   . PRO   A 1 154 ? 26.63600  -18.83100 -36.38800 1.000 29.88519 ? 350 PRO   A C   1 
ATOM   1070 O O   . PRO   A 1 154 ? 25.74700  -19.19300 -35.62400 1.000 29.55139 ? 350 PRO   A O   1 
ATOM   1071 C CB  . PRO   A 1 154 ? 28.57200  -19.84300 -35.18400 1.000 32.42637 ? 350 PRO   A CB  1 
ATOM   1072 C CG  . PRO   A 1 154 ? 29.41700  -18.56800 -35.10000 1.000 34.24616 ? 350 PRO   A CG  1 
ATOM   1073 C CD  . PRO   A 1 154 ? 29.87400  -18.29100 -36.52100 1.000 35.21917 ? 350 PRO   A CD  1 
ATOM   1074 N N   . PHE   A 1 155 ? 26.58200  -17.70700 -37.09300 1.000 29.28103 ? 351 PHE   A N   1 
ATOM   1075 C CA  . PHE   A 1 155 ? 25.50100  -16.75600 -36.85800 1.000 29.37533 ? 351 PHE   A CA  1 
ATOM   1076 C C   . PHE   A 1 155 ? 24.15000  -17.30200 -37.30000 1.000 27.34990 ? 351 PHE   A C   1 
ATOM   1077 O O   . PHE   A 1 155 ? 23.12200  -16.93600 -36.71600 1.000 27.36163 ? 351 PHE   A O   1 
ATOM   1078 C CB  . PHE   A 1 155 ? 25.83500  -15.44300 -37.55000 1.000 27.21091 ? 351 PHE   A CB  1 
ATOM   1079 C CG  . PHE   A 1 155 ? 27.06600  -14.79600 -36.99100 1.000 26.52526 ? 351 PHE   A CG  1 
ATOM   1080 C CD1 . PHE   A 1 155 ? 27.00900  -14.08400 -35.80300 1.000 26.42388 ? 351 PHE   A CD1 1 
ATOM   1081 C CD2 . PHE   A 1 155 ? 28.29900  -14.93300 -37.63200 1.000 29.16878 ? 351 PHE   A CD2 1 
ATOM   1082 C CE1 . PHE   A 1 155 ? 28.15700  -13.50800 -35.26200 1.000 29.07123 ? 351 PHE   A CE1 1 
ATOM   1083 C CE2 . PHE   A 1 155 ? 29.41800  -14.34700 -37.09900 1.000 29.28396 ? 351 PHE   A CE2 1 
ATOM   1084 C CZ  . PHE   A 1 155 ? 29.36100  -13.64200 -35.93000 1.000 29.92853 ? 351 PHE   A CZ  1 
ATOM   1085 N N   . CYS   A 1 156 ? 24.12600  -18.18000 -38.30600 1.000 27.77672 ? 352 CYS   A N   1 
ATOM   1086 C CA  . CYS   A 1 156 ? 22.87300  -18.77200 -38.74800 1.000 24.87218 ? 352 CYS   A CA  1 
ATOM   1087 C C   . CYS   A 1 156 ? 22.30500  -19.75900 -37.73900 1.000 27.10297 ? 352 CYS   A C   1 
ATOM   1088 O O   . CYS   A 1 156 ? 21.15400  -20.16000 -37.89200 1.000 28.12918 ? 352 CYS   A O   1 
ATOM   1089 C CB  . CYS   A 1 156 ? 23.05400  -19.48000 -40.09500 1.000 26.70534 ? 352 CYS   A CB  1 
ATOM   1090 S SG  . CYS   A 1 156 ? 24.38700  -20.74400 -40.06300 1.000 30.38145 ? 352 CYS   A SG  1 
ATOM   1091 N N   . ASP   A 1 157 ? 23.08900  -20.17200 -36.74700 1.000 24.27906 ? 353 ASP   A N   1 
ATOM   1092 C CA  . ASP   A 1 157 ? 22.63000  -21.14500 -35.75900 1.000 30.07061 ? 353 ASP   A CA  1 
ATOM   1093 C C   . ASP   A 1 157 ? 22.02800  -20.50200 -34.51400 1.000 27.92992 ? 353 ASP   A C   1 
ATOM   1094 O O   . ASP   A 1 157 ? 21.63100  -21.22700 -33.60200 1.000 30.82382 ? 353 ASP   A O   1 
ATOM   1095 C CB  . ASP   A 1 157 ? 23.78500  -22.05400 -35.33500 1.000 33.09526 ? 353 ASP   A CB  1 
ATOM   1096 C CG  . ASP   A 1 157 ? 24.36900  -22.82100 -36.49700 1.000 38.18623 ? 353 ASP   A CG  1 
ATOM   1097 O OD1 . ASP   A 1 157 ? 23.57800  -23.26000 -37.35000 1.000 38.98862 ? 353 ASP   A OD1 1 
ATOM   1098 O OD2 . ASP   A 1 157 ? 25.60900  -22.96800 -36.55800 1.000 42.27623 ? 353 ASP   A OD2 1 
ATOM   1099 N N   . ILE   A 1 158 ? 21.94900  -19.17100 -34.44700 1.000 26.59227 ? 354 ILE   A N   1 
ATOM   1100 C CA  . ILE   A 1 158 ? 21.52000  -18.52000 -33.21600 1.000 23.63538 ? 354 ILE   A CA  1 
ATOM   1101 C C   . ILE   A 1 158 ? 19.99500  -18.49800 -33.08900 1.000 24.12584 ? 354 ILE   A C   1 
ATOM   1102 O O   . ILE   A 1 158 ? 19.44800  -18.87100 -32.03800 1.000 24.46708 ? 354 ILE   A O   1 
ATOM   1103 C CB  . ILE   A 1 158 ? 22.10600  -17.10400 -33.13800 1.000 23.97892 ? 354 ILE   A CB  1 
ATOM   1104 C CG1 . ILE   A 1 158 ? 23.63200  -17.17500 -33.06600 1.000 25.91938 ? 354 ILE   A CG1 1 
ATOM   1105 C CG2 . ILE   A 1 158 ? 21.57500  -16.38500 -31.88200 1.000 22.77195 ? 354 ILE   A CG2 1 
ATOM   1106 C CD1 . ILE   A 1 158 ? 24.30300  -15.79800 -33.34500 1.000 24.98421 ? 354 ILE   A CD1 1 
ATOM   1107 N N   . MET   A 1 159 ? 19.28300  -18.06100 -34.12600 1.000 22.50355 ? 355 MET   A N   1 
ATOM   1108 C CA  . MET   A 1 159 ? 17.86000  -17.75800 -33.93800 1.000 24.12621 ? 355 MET   A CA  1 
ATOM   1109 C C   . MET   A 1 159 ? 16.94300  -18.95800 -34.15200 1.000 26.54196 ? 355 MET   A C   1 
ATOM   1110 O O   . MET   A 1 159 ? 15.82800  -18.97100 -33.61600 1.000 22.03556 ? 355 MET   A O   1 
ATOM   1111 C CB  . MET   A 1 159 ? 17.44400  -16.62800 -34.87600 1.000 23.05193 ? 355 MET   A CB  1 
ATOM   1112 C CG  . MET   A 1 159 ? 17.91700  -15.22300 -34.47100 1.000 26.24714 ? 355 MET   A CG  1 
ATOM   1113 S SD  . MET   A 1 159 ? 17.77800  -14.87900 -32.71100 1.000 25.91512 ? 355 MET   A SD  1 
ATOM   1114 C CE  . MET   A 1 159 ? 16.04400  -14.47700 -32.60400 1.000 24.41044 ? 355 MET   A CE  1 
ATOM   1115 N N   . GLU   A 1 160 ? 17.35400  -19.96400 -34.92100 1.000 24.42109 ? 356 GLU   A N   1 
ATOM   1116 C CA  . GLU   A 1 160 ? 16.43300  -21.05800 -35.24100 1.000 25.70543 ? 356 GLU   A CA  1 
ATOM   1117 C C   . GLU   A 1 160 ? 15.82100  -21.72400 -34.01700 1.000 24.24860 ? 356 GLU   A C   1 
ATOM   1118 O O   . GLU   A 1 160 ? 14.60300  -21.96900 -34.03500 1.000 23.07765 ? 356 GLU   A O   1 
ATOM   1119 C CB  . GLU   A 1 160 ? 17.11300  -22.10900 -36.12900 1.000 32.35014 ? 356 GLU   A CB  1 
ATOM   1120 C CG  . GLU   A 1 160 ? 16.81500  -21.99600 -37.62500 1.000 33.16361 ? 356 GLU   A CG  1 
ATOM   1121 C CD  . GLU   A 1 160 ? 15.32600  -21.88700 -37.96600 1.000 33.81488 ? 356 GLU   A CD  1 
ATOM   1122 O OE1 . GLU   A 1 160 ? 14.86200  -20.75600 -38.16200 1.000 29.77906 ? 356 GLU   A OE1 1 
ATOM   1123 O OE2 . GLU   A 1 160 ? 14.60700  -22.91200 -38.05100 1.000 38.00472 ? 356 GLU   A OE2 1 
ATOM   1124 N N   . PRO   A 1 161 ? 16.56400  -22.04500 -32.94700 1.000 22.55407 ? 357 PRO   A N   1 
ATOM   1125 C CA  . PRO   A 1 161 ? 15.92900  -22.64300 -31.75500 1.000 23.97270 ? 357 PRO   A CA  1 
ATOM   1126 C C   . PRO   A 1 161 ? 14.93400  -21.70400 -31.09500 1.000 21.91523 ? 357 PRO   A C   1 
ATOM   1127 O O   . PRO   A 1 161 ? 13.99800  -22.16800 -30.43000 1.000 22.90857 ? 357 PRO   A O   1 
ATOM   1128 C CB  . PRO   A 1 161 ? 17.11100  -22.92900 -30.81400 1.000 25.78030 ? 357 PRO   A CB  1 
ATOM   1129 C CG  . PRO   A 1 161 ? 18.29500  -22.93900 -31.69800 1.000 27.89997 ? 357 PRO   A CG  1 
ATOM   1130 C CD  . PRO   A 1 161 ? 18.04000  -22.01400 -32.82000 1.000 24.14966 ? 357 PRO   A CD  1 
ATOM   1131 N N   . LYS   A 1 162 ? 15.15500  -20.39600 -31.23900 1.000 20.19861 ? 358 LYS   A N   1 
ATOM   1132 C CA  . LYS   A 1 162 ? 14.22600  -19.42200 -30.67200 1.000 19.46757 ? 358 LYS   A CA  1 
ATOM   1133 C C   . LYS   A 1 162 ? 12.94600  -19.36200 -31.49100 1.000 19.64315 ? 358 LYS   A C   1 
ATOM   1134 O O   . LYS   A 1 162 ? 11.85300  -19.26600 -30.91700 1.000 19.82652 ? 358 LYS   A O   1 
ATOM   1135 C CB  . LYS   A 1 162 ? 14.89400  -18.05000 -30.60100 1.000 20.39864 ? 358 LYS   A CB  1 
ATOM   1136 C CG  . LYS   A 1 162 ? 15.93200  -17.86800 -29.45000 1.000 22.83348 ? 358 LYS   A CG  1 
ATOM   1137 C CD  . LYS   A 1 162 ? 17.12800  -18.76800 -29.60000 1.000 24.86664 ? 358 LYS   A CD  1 
ATOM   1138 C CE  . LYS   A 1 162 ? 18.31400  -18.18800 -28.85900 1.000 22.93386 ? 358 LYS   A CE  1 
ATOM   1139 N NZ  . LYS   A 1 162 ? 19.55200  -18.95900 -29.26000 1.000 21.44118 ? 358 LYS   A NZ  1 
ATOM   1140 N N   . PHE   A 1 163 ? 13.04500  -19.43300 -32.82300 1.000 19.43095 ? 359 PHE   A N   1 
ATOM   1141 C CA  . PHE   A 1 163 ? 11.82300  -19.55100 -33.62700 1.000 19.64303 ? 359 PHE   A CA  1 
ATOM   1142 C C   . PHE   A 1 163 ? 11.06300  -20.83500 -33.28500 1.000 21.11953 ? 359 PHE   A C   1 
ATOM   1143 O O   . PHE   A 1 163 ? 9.82900   -20.82100 -33.17900 1.000 20.76038 ? 359 PHE   A O   1 
ATOM   1144 C CB  . PHE   A 1 163 ? 12.15200  -19.51900 -35.13200 1.000 20.47809 ? 359 PHE   A CB  1 
ATOM   1145 C CG  . PHE   A 1 163 ? 12.35300  -18.12900 -35.69800 1.000 20.08670 ? 359 PHE   A CG  1 
ATOM   1146 C CD1 . PHE   A 1 163 ? 11.25500  -17.31500 -36.01400 1.000 22.44191 ? 359 PHE   A CD1 1 
ATOM   1147 C CD2 . PHE   A 1 163 ? 13.63200  -17.64500 -35.93700 1.000 22.74991 ? 359 PHE   A CD2 1 
ATOM   1148 C CE1 . PHE   A 1 163 ? 11.46000  -16.03200 -36.52600 1.000 22.98584 ? 359 PHE   A CE1 1 
ATOM   1149 C CE2 . PHE   A 1 163 ? 13.82800  -16.37400 -36.44700 1.000 19.46727 ? 359 PHE   A CE2 1 
ATOM   1150 C CZ  . PHE   A 1 163 ? 12.74500  -15.56700 -36.75700 1.000 19.50065 ? 359 PHE   A CZ  1 
ATOM   1151 N N   . ASP   A 1 164 ? 11.78300  -21.95200 -33.11700 1.000 20.33139 ? 360 ASP   A N   1 
ATOM   1152 C CA  . ASP   A 1 164 ? 11.14300  -23.22100 -32.78900 1.000 20.02337 ? 360 ASP   A CA  1 
ATOM   1153 C C   . ASP   A 1 164 ? 10.39600  -23.11000 -31.46300 1.000 22.72057 ? 360 ASP   A C   1 
ATOM   1154 O O   . ASP   A 1 164 ? 9.23000   -23.52500 -31.35500 1.000 22.80546 ? 360 ASP   A O   1 
ATOM   1155 C CB  . ASP   A 1 164 ? 12.20800  -24.31700 -32.72700 1.000 25.34588 ? 360 ASP   A CB  1 
ATOM   1156 C CG  . ASP   A 1 164 ? 12.53500  -24.90100 -34.09500 1.000 30.85906 ? 360 ASP   A CG  1 
ATOM   1157 O OD1 . ASP   A 1 164 ? 11.83800  -24.55600 -35.06900 1.000 31.92024 ? 360 ASP   A OD1 1 
ATOM   1158 O OD2 . ASP   A 1 164 ? 13.51700  -25.67100 -34.18800 1.000 37.31064 ? 360 ASP   A OD2 1 
ATOM   1159 N N   . PHE   A 1 165 ? 11.05000  -22.52500 -30.44400 1.000 20.34120 ? 361 PHE   A N   1 
ATOM   1160 C CA  . PHE   A 1 165 ? 10.37400  -22.29900 -29.17100 1.000 21.13229 ? 361 PHE   A CA  1 
ATOM   1161 C C   . PHE   A 1 165 ? 9.13800   -21.43400 -29.36600 1.000 21.25409 ? 361 PHE   A C   1 
ATOM   1162 O O   . PHE   A 1 165 ? 8.06100   -21.75000 -28.84600 1.000 20.56086 ? 361 PHE   A O   1 
ATOM   1163 C CB  . PHE   A 1 165 ? 11.32000  -21.62900 -28.15600 1.000 19.57509 ? 361 PHE   A CB  1 
ATOM   1164 C CG  . PHE   A 1 165 ? 10.62800  -21.27300 -26.87100 1.000 18.85378 ? 361 PHE   A CG  1 
ATOM   1165 C CD1 . PHE   A 1 165 ? 10.59400  -22.18400 -25.82700 1.000 20.65160 ? 361 PHE   A CD1 1 
ATOM   1166 C CD2 . PHE   A 1 165 ? 9.97600   -20.05100 -26.72400 1.000 20.67468 ? 361 PHE   A CD2 1 
ATOM   1167 C CE1 . PHE   A 1 165 ? 9.93300   -21.89800 -24.64600 1.000 22.33254 ? 361 PHE   A CE1 1 
ATOM   1168 C CE2 . PHE   A 1 165 ? 9.28300   -19.75700 -25.53500 1.000 18.36038 ? 361 PHE   A CE2 1 
ATOM   1169 C CZ  . PHE   A 1 165 ? 9.28000   -20.68700 -24.49500 1.000 20.89241 ? 361 PHE   A CZ  1 
ATOM   1170 N N   . ALA   A 1 166 ? 9.29800   -20.31600 -30.08300 1.000 20.16568 ? 362 ALA   A N   1 
ATOM   1171 C CA  . ALA   A 1 166 ? 8.20400   -19.35200 -30.26600 1.000 18.45100 ? 362 ALA   A CA  1 
ATOM   1172 C C   . ALA   A 1 166 ? 7.00700   -19.96900 -30.96600 1.000 20.49446 ? 362 ALA   A C   1 
ATOM   1173 O O   . ALA   A 1 166 ? 5.86500   -19.60500 -30.66400 1.000 21.39537 ? 362 ALA   A O   1 
ATOM   1174 C CB  . ALA   A 1 166 ? 8.68600   -18.14800 -31.07700 1.000 19.79869 ? 362 ALA   A CB  1 
ATOM   1175 N N   . MET   A 1 167 ? 7.23000   -20.86700 -31.93900 1.000 18.36711 ? 363 MET   A N   1 
ATOM   1176 C CA  . MET   A 1 167 ? 6.05400   -21.34100 -32.67900 1.000 20.63005 ? 363 MET   A CA  1 
ATOM   1177 C C   . MET   A 1 167 ? 5.16100   -22.20000 -31.78900 1.000 23.38577 ? 363 MET   A C   1 
ATOM   1178 O O   . MET   A 1 167 ? 3.92200   -22.06700 -31.82700 1.000 21.84502 ? 363 MET   A O   1 
ATOM   1179 C CB  . MET   A 1 167 ? 6.45800   -22.08900 -33.95300 1.000 25.14832 ? 363 MET   A CB  1 
ATOM   1180 C CG  . MET   A 1 167 ? 7.20700   -21.17600 -34.90100 1.000 26.54452 ? 363 MET   A CG  1 
ATOM   1181 S SD  . MET   A 1 167 ? 6.30300   -19.83400 -35.61700 1.000 30.63458 ? 363 MET   A SD  1 
ATOM   1182 C CE  . MET   A 1 167 ? 6.93500   -18.50600 -34.54700 1.000 29.41552 ? 363 MET   A CE  1 
ATOM   1183 N N   . LYS   A 1 168 ? 5.76100   -23.02100 -30.93600 1.000 21.33597 ? 364 LYS   A N   1 
ATOM   1184 C CA  . LYS   A 1 168 ? 4.98900   -23.76900 -29.94500 1.000 20.79765 ? 364 LYS   A CA  1 
ATOM   1185 C C   . LYS   A 1 168 ? 4.43100   -22.86200 -28.85300 1.000 22.25064 ? 364 LYS   A C   1 
ATOM   1186 O O   . LYS   A 1 168 ? 3.31700   -23.08200 -28.37200 1.000 24.57346 ? 364 LYS   A O   1 
ATOM   1187 C CB  . LYS   A 1 168 ? 5.86700   -24.86100 -29.33700 1.000 25.24011 ? 364 LYS   A CB  1 
ATOM   1188 C CG  . LYS   A 1 168 ? 6.29200   -25.91900 -30.36500 1.000 29.98378 ? 364 LYS   A CG  1 
ATOM   1189 C CD  . LYS   A 1 168 ? 7.10600   -27.02000 -29.73200 1.000 35.14149 ? 364 LYS   A CD  1 
ATOM   1190 C CE  . LYS   A 1 168 ? 8.48200   -26.52300 -29.33800 1.000 42.92623 ? 364 LYS   A CE  1 
ATOM   1191 N NZ  . LYS   A 1 168 ? 9.57500   -27.22400 -30.07800 1.000 47.99623 ? 364 LYS   A NZ  1 
ATOM   1192 N N   . PHE   A 1 169 ? 5.20100   -21.85600 -28.41600 1.000 20.95623 ? 365 PHE   A N   1 
ATOM   1193 C CA  . PHE   A 1 169 ? 4.70100   -20.96200 -27.37000 1.000 20.82114 ? 365 PHE   A CA  1 
ATOM   1194 C C   . PHE   A 1 169 ? 3.48800   -20.17900 -27.86400 1.000 20.49297 ? 365 PHE   A C   1 
ATOM   1195 O O   . PHE   A 1 169 ? 2.47300   -20.05900 -27.15500 1.000 20.82619 ? 365 PHE   A O   1 
ATOM   1196 C CB  . PHE   A 1 169 ? 5.82100   -20.01600 -26.92400 1.000 19.44131 ? 365 PHE   A CB  1 
ATOM   1197 C CG  . PHE   A 1 169 ? 5.55300   -19.30500 -25.62400 1.000 18.10099 ? 365 PHE   A CG  1 
ATOM   1198 C CD1 . PHE   A 1 169 ? 5.69000   -19.98100 -24.41400 1.000 21.67556 ? 365 PHE   A CD1 1 
ATOM   1199 C CD2 . PHE   A 1 169 ? 5.18700   -17.96100 -25.61000 1.000 20.78816 ? 365 PHE   A CD2 1 
ATOM   1200 C CE1 . PHE   A 1 169 ? 5.47400   -19.32600 -23.19800 1.000 22.88892 ? 365 PHE   A CE1 1 
ATOM   1201 C CE2 . PHE   A 1 169 ? 4.95100   -17.28300 -24.39000 1.000 21.47986 ? 365 PHE   A CE2 1 
ATOM   1202 C CZ  . PHE   A 1 169 ? 5.10700   -17.96800 -23.18300 1.000 18.94572 ? 365 PHE   A CZ  1 
ATOM   1203 N N   . ASN   A 1 170 ? 3.55800   -19.68300 -29.09800 1.000 18.97939 ? 366 ASN   A N   1 
ATOM   1204 C CA  . ASN   A 1 170 ? 2.47100   -18.88900 -29.65400 1.000 17.69246 ? 366 ASN   A CA  1 
ATOM   1205 C C   . ASN   A 1 170 ? 1.24900   -19.74300 -29.88400 1.000 24.50208 ? 366 ASN   A C   1 
ATOM   1206 O O   . ASN   A 1 170 ? 0.13600   -19.21100 -29.87100 1.000 22.83860 ? 366 ASN   A O   1 
ATOM   1207 C CB  . ASN   A 1 170 ? 2.92600   -18.22300 -30.95600 1.000 18.85335 ? 366 ASN   A CB  1 
ATOM   1208 C CG  . ASN   A 1 170 ? 3.85300   -17.04300 -30.71600 1.000 21.08623 ? 366 ASN   A CG  1 
ATOM   1209 O OD1 . ASN   A 1 170 ? 3.97400   -16.52500 -29.58300 1.000 22.64827 ? 366 ASN   A OD1 1 
ATOM   1210 N ND2 . ASN   A 1 170 ? 4.52600   -16.60100 -31.79600 1.000 20.72431 ? 366 ASN   A ND2 1 
ATOM   1211 N N   . ALA   A 1 171 ? 1.42400   -21.05200 -30.00800 1.000 21.67007 ? 367 ALA   A N   1 
ATOM   1212 C CA  . ALA   A 1 171 ? 0.25300   -21.92000 -30.18200 1.000 22.85383 ? 367 ALA   A CA  1 
ATOM   1213 C C   . ALA   A 1 171 ? -0.59100  -22.03800 -28.91400 1.000 26.88259 ? 367 ALA   A C   1 
ATOM   1214 O O   . ALA   A 1 171 ? -1.75300  -22.47300 -28.99800 1.000 27.00227 ? 367 ALA   A O   1 
ATOM   1215 C CB  . ALA   A 1 171 ? 0.71000   -23.30800 -30.65400 1.000 26.98703 ? 367 ALA   A CB  1 
ATOM   1216 N N   . LEU   A 1 172 ? -0.04700  -21.65400 -27.75400 1.000 22.12880 ? 368 LEU   A N   1 
ATOM   1217 C CA  . LEU   A 1 172 ? -0.82800  -21.56100 -26.50500 1.000 20.93645 ? 368 LEU   A CA  1 
ATOM   1218 C C   . LEU   A 1 172 ? -1.80800  -20.40100 -26.51900 1.000 21.98383 ? 368 LEU   A C   1 
ATOM   1219 O O   . LEU   A 1 172 ? -2.72100  -20.35900 -25.67600 1.000 24.13057 ? 368 LEU   A O   1 
ATOM   1220 C CB  . LEU   A 1 172 ? 0.10400   -21.42200 -25.30100 1.000 21.70942 ? 368 LEU   A CB  1 
ATOM   1221 C CG  . LEU   A 1 172 ? 1.15600   -22.52900 -25.13200 1.000 26.96317 ? 368 LEU   A CG  1 
ATOM   1222 C CD1 . LEU   A 1 172 ? 2.05100   -22.25200 -23.92300 1.000 26.79244 ? 368 LEU   A CD1 1 
ATOM   1223 C CD2 . LEU   A 1 172 ? 0.47700   -23.91500 -25.00300 1.000 27.28761 ? 368 LEU   A CD2 1 
ATOM   1224 N N   . GLU   A 1 173 ? -1.62300  -19.45000 -27.42800 1.000 20.23895 ? 369 GLU   A N   1 
ATOM   1225 C CA  . GLU   A 1 173 ? -2.49400  -18.29100 -27.59400 1.000 21.00760 ? 369 GLU   A CA  1 
ATOM   1226 C C   . GLU   A 1 173 ? -2.63400  -17.48200 -26.29900 1.000 23.21837 ? 369 GLU   A C   1 
ATOM   1227 O O   . GLU   A 1 173 ? -3.71400  -17.03300 -25.91100 1.000 25.06962 ? 369 GLU   A O   1 
ATOM   1228 C CB  . GLU   A 1 173 ? -3.85300  -18.72800 -28.16200 1.000 26.72352 ? 369 GLU   A CB  1 
ATOM   1229 C CG  . GLU   A 1 173 ? -3.74900  -19.24400 -29.60100 1.000 31.84792 ? 369 GLU   A CG  1 
ATOM   1230 C CD  . GLU   A 1 173 ? -3.45100  -18.13900 -30.62300 1.000 35.95237 ? 369 GLU   A CD  1 
ATOM   1231 O OE1 . GLU   A 1 173 ? -3.43600  -18.45600 -31.83900 1.000 47.93623 ? 369 GLU   A OE1 1 
ATOM   1232 O OE2 . GLU   A 1 173 ? -3.25900  -16.95800 -30.22900 1.000 39.03623 ? 369 GLU   A OE2 1 
ATOM   1233 N N   . LEU   A 1 174 ? -1.50400  -17.24600 -25.63800 1.000 20.38317 ? 370 LEU   A N   1 
ATOM   1234 C CA  . LEU   A 1 174 ? -1.51800  -16.33900 -24.51100 1.000 19.12650 ? 370 LEU   A CA  1 
ATOM   1235 C C   . LEU   A 1 174 ? -1.74800  -14.90300 -24.98000 1.000 19.61100 ? 370 LEU   A C   1 
ATOM   1236 O O   . LEU   A 1 174 ? -1.43800  -14.52100 -26.11700 1.000 22.80303 ? 370 LEU   A O   1 
ATOM   1237 C CB  . LEU   A 1 174 ? -0.17400  -16.40100 -23.76800 1.000 18.49691 ? 370 LEU   A CB  1 
ATOM   1238 C CG  . LEU   A 1 174 ? 0.27900   -17.76500 -23.24900 1.000 21.07715 ? 370 LEU   A CG  1 
ATOM   1239 C CD1 . LEU   A 1 174 ? 1.57600   -17.62200 -22.43100 1.000 25.69116 ? 370 LEU   A CD1 1 
ATOM   1240 C CD2 . LEU   A 1 174 ? -0.78500  -18.42600 -22.40200 1.000 23.86228 ? 370 LEU   A CD2 1 
ATOM   1241 N N   . ASP   A 1 175 ? -2.26900  -14.09700 -24.07300 1.000 18.62454 ? 371 ASP   A N   1 
ATOM   1242 C CA  . ASP   A 1 175 ? -2.33100  -12.66800 -24.30300 1.000 19.16345 ? 371 ASP   A CA  1 
ATOM   1243 C C   . ASP   A 1 175 ? -1.37600  -11.94600 -23.34500 1.000 21.74078 ? 371 ASP   A C   1 
ATOM   1244 O O   . ASP   A 1 175 ? -0.70500  -12.55500 -22.48700 1.000 19.62689 ? 371 ASP   A O   1 
ATOM   1245 C CB  . ASP   A 1 175 ? -3.79900  -12.19200 -24.24800 1.000 22.20300 ? 371 ASP   A CB  1 
ATOM   1246 C CG  . ASP   A 1 175 ? -4.42500  -12.27700 -22.87100 1.000 24.01109 ? 371 ASP   A CG  1 
ATOM   1247 O OD1 . ASP   A 1 175 ? -3.75600  -12.13300 -21.83600 1.000 22.73262 ? 371 ASP   A OD1 1 
ATOM   1248 O OD2 . ASP   A 1 175 ? -5.66800  -12.53800 -22.85300 1.000 26.14440 ? 371 ASP   A OD2 1 
ATOM   1249 N N   . ASP   A 1 176 ? -1.29300  -10.61800 -23.50200 1.000 20.03506 ? 372 ASP   A N   1 
ATOM   1250 C CA  . ASP   A 1 176 ? -0.34900  -9.85100  -22.69000 1.000 19.15787 ? 372 ASP   A CA  1 
ATOM   1251 C C   . ASP   A 1 176 ? -0.60300  -10.00500 -21.18400 1.000 19.96038 ? 372 ASP   A C   1 
ATOM   1252 O O   . ASP   A 1 176 ? 0.34400   -9.94300  -20.38700 1.000 20.31590 ? 372 ASP   A O   1 
ATOM   1253 C CB  . ASP   A 1 176 ? -0.38500  -8.37200  -23.08400 1.000 22.30624 ? 372 ASP   A CB  1 
ATOM   1254 C CG  . ASP   A 1 176 ? 0.20900   -8.11200  -24.46900 1.000 28.03474 ? 372 ASP   A CG  1 
ATOM   1255 O OD1 . ASP   A 1 176 ? 1.38900   -8.46700  -24.68900 1.000 23.94241 ? 372 ASP   A OD1 1 
ATOM   1256 O OD2 . ASP   A 1 176 ? -0.51200  -7.56000  -25.33000 1.000 29.14091 ? 372 ASP   A OD2 1 
ATOM   1257 N N   . SER   A 1 177 ? -1.88000  -10.14700 -20.76300 1.000 18.03813 ? 373 SER   A N   1 
ATOM   1258 C CA  . SER   A 1 177 ? -2.14800  -10.32500 -19.34000 1.000 19.34770 ? 373 SER   A CA  1 
ATOM   1259 C C   . SER   A 1 177 ? -1.52700  -11.63500 -18.82800 1.000 22.07417 ? 373 SER   A C   1 
ATOM   1260 O O   . SER   A 1 177 ? -0.95000  -11.66200 -17.73100 1.000 22.88724 ? 373 SER   A O   1 
ATOM   1261 C CB  . SER   A 1 177 ? -3.66600  -10.24700 -19.04900 1.000 21.93931 ? 373 SER   A CB  1 
ATOM   1262 O OG  . SER   A 1 177 ? -4.39900  -11.39200 -19.43700 1.000 22.79682 ? 373 SER   A OG  1 
ATOM   1263 N N   . ASP   A 1 178 ? -1.59200  -12.70400 -19.62500 1.000 20.53573 ? 374 ASP   A N   1 
ATOM   1264 C CA  . ASP   A 1 178 ? -0.90700  -13.95300 -19.26900 1.000 18.64478 ? 374 ASP   A CA  1 
ATOM   1265 C C   . ASP   A 1 178 ? 0.60500   -13.78700 -19.25700 1.000 16.85029 ? 374 ASP   A C   1 
ATOM   1266 O O   . ASP   A 1 178 ? 1.27200   -14.27700 -18.35200 1.000 17.01451 ? 374 ASP   A O   1 
ATOM   1267 C CB  . ASP   A 1 178 ? -1.23900  -15.06300 -20.26100 1.000 19.10753 ? 374 ASP   A CB  1 
ATOM   1268 C CG  . ASP   A 1 178 ? -2.72000  -15.23400 -20.50500 1.000 23.18507 ? 374 ASP   A CG  1 
ATOM   1269 O OD1 . ASP   A 1 178 ? -3.51300  -15.31300 -19.53500 1.000 20.70797 ? 374 ASP   A OD1 1 
ATOM   1270 O OD2 . ASP   A 1 178 ? -3.07500  -15.36300 -21.66700 1.000 21.46404 ? 374 ASP   A OD2 1 
ATOM   1271 N N   . ILE   A 1 179 ? 1.13400   -13.13300 -20.28600 1.000 18.32176 ? 375 ILE   A N   1 
ATOM   1272 C CA  . ILE   A 1 179 ? 2.58200   -13.08300 -20.45700 1.000 16.29331 ? 375 ILE   A CA  1 
ATOM   1273 C C   . ILE   A 1 179 ? 3.20600   -12.26500 -19.34000 1.000 18.24579 ? 375 ILE   A C   1 
ATOM   1274 O O   . ILE   A 1 179 ? 4.29600   -12.59500 -18.85600 1.000 18.07300 ? 375 ILE   A O   1 
ATOM   1275 C CB  . ILE   A 1 179 ? 2.91100   -12.52600 -21.84700 1.000 15.81428 ? 375 ILE   A CB  1 
ATOM   1276 C CG1 . ILE   A 1 179 ? 2.46200   -13.48500 -22.96100 1.000 17.85207 ? 375 ILE   A CG1 1 
ATOM   1277 C CG2 . ILE   A 1 179 ? 4.45400   -12.28400 -22.01500 1.000 16.24973 ? 375 ILE   A CG2 1 
ATOM   1278 C CD1 . ILE   A 1 179 ? 2.33500   -12.76500 -24.33200 1.000 20.21333 ? 375 ILE   A CD1 1 
ATOM   1279 N N   . SER   A 1 180 ? 2.52000   -11.19300 -18.90500 1.000 17.88129 ? 376 SER   A N   1 
ATOM   1280 C CA  . SER   A 1 180 ? 3.06600   -10.36300 -17.83600 1.000 19.41155 ? 376 SER   A CA  1 
ATOM   1281 C C   . SER   A 1 180 ? 3.25600   -11.18400 -16.56300 1.000 17.94268 ? 376 SER   A C   1 
ATOM   1282 O O   . SER   A 1 180 ? 4.27700   -11.04400 -15.88300 1.000 17.70759 ? 376 SER   A O   1 
ATOM   1283 C CB  . SER   A 1 180 ? 2.14600   -9.14200  -17.59800 1.000 20.22357 ? 376 SER   A CB  1 
ATOM   1284 O OG  . SER   A 1 180 ? 0.91400   -9.56400  -17.05700 1.000 20.31412 ? 376 SER   A OG  1 
ATOM   1285 N N   . LEU   A 1 181 ? 2.31800   -12.07400 -16.24600 1.000 17.82832 ? 377 LEU   A N   1 
ATOM   1286 C CA  . LEU   A 1 181 ? 2.43500   -12.88300 -15.03400 1.000 18.65508 ? 377 LEU   A CA  1 
ATOM   1287 C C   . LEU   A 1 181 ? 3.49600   -13.95900 -15.22000 1.000 21.50654 ? 377 LEU   A C   1 
ATOM   1288 O O   . LEU   A 1 181 ? 4.21800   -14.28600 -14.27700 1.000 20.84082 ? 377 LEU   A O   1 
ATOM   1289 C CB  . LEU   A 1 181 ? 1.09400   -13.52200 -14.66700 1.000 19.53922 ? 377 LEU   A CB  1 
ATOM   1290 C CG  . LEU   A 1 181 ? -0.02300  -12.49700 -14.46000 1.000 24.09084 ? 377 LEU   A CG  1 
ATOM   1291 C CD1 . LEU   A 1 181 ? -1.34700  -13.17400 -14.10500 1.000 24.53007 ? 377 LEU   A CD1 1 
ATOM   1292 C CD2 . LEU   A 1 181 ? 0.35500   -11.46500 -13.42500 1.000 30.21470 ? 377 LEU   A CD2 1 
ATOM   1293 N N   . PHE   A 1 182 ? 3.58500   -14.51000 -16.43700 1.000 19.32902 ? 378 PHE   A N   1 
ATOM   1294 C CA  . PHE   A 1 182 ? 4.58300   -15.53800 -16.73900 1.000 18.29927 ? 378 PHE   A CA  1 
ATOM   1295 C C   . PHE   A 1 182 ? 5.99200   -14.97500 -16.60300 1.000 18.51799 ? 378 PHE   A C   1 
ATOM   1296 O O   . PHE   A 1 182 ? 6.86800   -15.61300 -15.99500 1.000 19.28497 ? 378 PHE   A O   1 
ATOM   1297 C CB  . PHE   A 1 182 ? 4.31400   -16.08700 -18.15500 1.000 18.79593 ? 378 PHE   A CB  1 
ATOM   1298 C CG  . PHE   A 1 182 ? 5.26200   -17.18300 -18.59500 1.000 18.86177 ? 378 PHE   A CG  1 
ATOM   1299 C CD1 . PHE   A 1 182 ? 5.14100   -18.46600 -18.07800 1.000 22.98202 ? 378 PHE   A CD1 1 
ATOM   1300 C CD2 . PHE   A 1 182 ? 6.24200   -16.90100 -19.54100 1.000 21.85861 ? 378 PHE   A CD2 1 
ATOM   1301 C CE1 . PHE   A 1 182 ? 6.02400   -19.48800 -18.53000 1.000 26.06762 ? 378 PHE   A CE1 1 
ATOM   1302 C CE2 . PHE   A 1 182 ? 7.13200   -17.90300 -19.97500 1.000 21.67780 ? 378 PHE   A CE2 1 
ATOM   1303 C CZ  . PHE   A 1 182 ? 7.00400   -19.19300 -19.46800 1.000 22.65750 ? 378 PHE   A CZ  1 
ATOM   1304 N N   . VAL   A 1 183 ? 6.20800   -13.75500 -17.10100 1.000 16.13753 ? 379 VAL   A N   1 
ATOM   1305 C CA  . VAL   A 1 183 ? 7.52500   -13.10800 -16.99000 1.000 15.76887 ? 379 VAL   A CA  1 
ATOM   1306 C C   . VAL   A 1 183 ? 7.84500   -12.76100 -15.53400 1.000 18.11283 ? 379 VAL   A C   1 
ATOM   1307 O O   . VAL   A 1 183 ? 8.97900   -12.93800 -15.08100 1.000 18.11195 ? 379 VAL   A O   1 
ATOM   1308 C CB  . VAL   A 1 183 ? 7.58900   -11.88000 -17.91700 1.000 18.69953 ? 379 VAL   A CB  1 
ATOM   1309 C CG1 . VAL   A 1 183 ? 8.86400   -11.04200 -17.65100 1.000 21.44944 ? 379 VAL   A CG1 1 
ATOM   1310 C CG2 . VAL   A 1 183 ? 7.57600   -12.33700 -19.39000 1.000 17.79554 ? 379 VAL   A CG2 1 
ATOM   1311 N N   . ALA   A 1 184 ? 6.86400   -12.27100 -14.77900 1.000 18.20357 ? 380 ALA   A N   1 
ATOM   1312 C CA  . ALA   A 1 184 ? 7.08800   -12.06000 -13.35300 1.000 18.37277 ? 380 ALA   A CA  1 
ATOM   1313 C C   . ALA   A 1 184 ? 7.50700   -13.34900 -12.64200 1.000 21.35488 ? 380 ALA   A C   1 
ATOM   1314 O O   . ALA   A 1 184 ? 8.39200   -13.32500 -11.79000 1.000 20.91001 ? 380 ALA   A O   1 
ATOM   1315 C CB  . ALA   A 1 184 ? 5.81700   -11.48600 -12.71900 1.000 20.18475 ? 380 ALA   A CB  1 
ATOM   1316 N N   . ALA   A 1 185 ? 6.89200   -14.48100 -13.00000 1.000 18.71005 ? 381 ALA   A N   1 
ATOM   1317 C CA  . ALA   A 1 185 ? 7.23300   -15.78200 -12.42300 1.000 22.21952 ? 381 ALA   A CA  1 
ATOM   1318 C C   . ALA   A 1 185 ? 8.64700   -16.21300 -12.78500 1.000 24.02224 ? 381 ALA   A C   1 
ATOM   1319 O O   . ALA   A 1 185 ? 9.35600   -16.79100 -11.94600 1.000 24.50044 ? 381 ALA   A O   1 
ATOM   1320 C CB  . ALA   A 1 185 ? 6.22800   -16.82900 -12.91200 1.000 22.97171 ? 381 ALA   A CB  1 
ATOM   1321 N N   . ILE   A 1 186 ? 9.06800   -15.95800 -14.03000 1.000 20.17705 ? 382 ILE   A N   1 
ATOM   1322 C CA  . ILE   A 1 186 ? 10.44100  -16.24800 -14.43800 1.000 21.14601 ? 382 ILE   A CA  1 
ATOM   1323 C C   . ILE   A 1 186 ? 11.42700  -15.46700 -13.59000 1.000 24.21262 ? 382 ILE   A C   1 
ATOM   1324 O O   . ILE   A 1 186 ? 12.44600  -16.00500 -13.13300 1.000 25.31185 ? 382 ILE   A O   1 
ATOM   1325 C CB  . ILE   A 1 186 ? 10.61900  -15.91600 -15.93200 1.000 17.61968 ? 382 ILE   A CB  1 
ATOM   1326 C CG1 . ILE   A 1 186 ? 9.97300   -16.99500 -16.79500 1.000 21.32343 ? 382 ILE   A CG1 1 
ATOM   1327 C CG2 . ILE   A 1 186 ? 12.09800  -15.80700 -16.28600 1.000 19.43778 ? 382 ILE   A CG2 1 
ATOM   1328 C CD1 . ILE   A 1 186 ? 9.82200   -16.53600 -18.22200 1.000 24.21380 ? 382 ILE   A CD1 1 
ATOM   1329 N N   . ILE   A 1 187 ? 11.16500  -14.17300 -13.39200 1.000 20.84357 ? 383 ILE   A N   1 
ATOM   1330 C CA  . ILE   A 1 187 ? 12.09400  -13.33300 -12.64400 1.000 22.32969 ? 383 ILE   A CA  1 
ATOM   1331 C C   . ILE   A 1 187 ? 12.15200  -13.74600 -11.16400 1.000 24.77257 ? 383 ILE   A C   1 
ATOM   1332 O O   . ILE   A 1 187 ? 13.24400  -13.84000 -10.57800 1.000 24.59797 ? 383 ILE   A O   1 
ATOM   1333 C CB  . ILE   A 1 187 ? 11.70200  -11.85600 -12.80800 1.000 22.45902 ? 383 ILE   A CB  1 
ATOM   1334 C CG1 . ILE   A 1 187 ? 11.89000  -11.41400 -14.25800 1.000 23.75437 ? 383 ILE   A CG1 1 
ATOM   1335 C CG2 . ILE   A 1 187 ? 12.55700  -10.97400 -11.85400 1.000 28.21888 ? 383 ILE   A CG2 1 
ATOM   1336 C CD1 . ILE   A 1 187 ? 11.16500  -10.11000 -14.59100 1.000 26.76594 ? 383 ILE   A CD1 1 
ATOM   1337 N N   . CYS   A 1 188 ? 11.00600  -14.03600 -10.54900 1.000 25.75308 ? 384 CYS   A N   1 
ATOM   1338 C CA  . CYS   A 1 188 ? 10.94900  -14.29600 -9.09600  1.000 26.84819 ? 384 CYS   A CA  1 
ATOM   1339 C C   . CYS   A 1 188 ? 11.08900  -15.78900 -8.84600  1.000 29.00198 ? 384 CYS   A C   1 
ATOM   1340 O O   . CYS   A 1 188 ? 10.12400  -16.50200 -8.57200  1.000 37.24810 ? 384 CYS   A O   1 
ATOM   1341 C CB  . CYS   A 1 188 ? 9.65300   -13.75700 -8.51300  1.000 29.36545 ? 384 CYS   A CB  1 
ATOM   1342 S SG  . CYS   A 1 188 ? 9.54700   -12.00200 -8.74300  1.000 34.68627 ? 384 CYS   A SG  1 
ATOM   1343 N N   . CYS   A 1 189 ? 12.31800  -16.26500 -8.94900  1.000 30.90649 ? 385 CYS   A N   1 
ATOM   1344 C CA  . CYS   A 1 189 ? 12.61200  -17.69500 -8.96200  1.000 29.87564 ? 385 CYS   A CA  1 
ATOM   1345 C C   . CYS   A 1 189 ? 13.63800  -17.98000 -7.87400  1.000 35.47147 ? 385 CYS   A C   1 
ATOM   1346 O O   . CYS   A 1 189 ? 14.75800  -17.46900 -7.93100  1.000 31.78973 ? 385 CYS   A O   1 
ATOM   1347 C CB  . CYS   A 1 189 ? 13.12900  -18.10800 -10.34300 1.000 33.74380 ? 385 CYS   A CB  1 
ATOM   1348 S SG  . CYS   A 1 189 ? 13.93700  -19.70100 -10.42300 1.000 41.20920 ? 385 CYS   A SG  1 
ATOM   1349 N N   . GLY   A 1 190 ? 13.25200  -18.77400 -6.88000  1.000 33.30099 ? 386 GLY   A N   1 
ATOM   1350 C CA  . GLY   A 1 190 ? 14.13100  -19.03800 -5.74500  1.000 37.29335 ? 386 GLY   A CA  1 
ATOM   1351 C C   . GLY   A 1 190 ? 15.25700  -20.00800 -6.01800  1.000 40.82590 ? 386 GLY   A C   1 
ATOM   1352 O O   . GLY   A 1 190 ? 16.10900  -20.22100 -5.14700  1.000 43.88407 ? 386 GLY   A O   1 
ATOM   1353 N N   . ASP   A 1 191 ? 15.27700  -20.58900 -7.21200  1.000 40.50405 ? 387 ASP   A N   1 
ATOM   1354 C CA  . ASP   A 1 191 ? 16.21900  -21.60300 -7.66400  1.000 42.13023 ? 387 ASP   A CA  1 
ATOM   1355 C C   . ASP   A 1 191 ? 17.57400  -21.04000 -8.07500  1.000 41.67640 ? 387 ASP   A C   1 
ATOM   1356 O O   . ASP   A 1 191 ? 18.50600  -21.81800 -8.30600  1.000 40.70437 ? 387 ASP   A O   1 
ATOM   1357 C CB  . ASP   A 1 191 ? 15.59800  -22.33000 -8.86500  1.000 47.80222 ? 387 ASP   A CB  1 
ATOM   1358 C CG  . ASP   A 1 191 ? 15.88600  -23.80500 -8.88000  1.000 63.45623 ? 387 ASP   A CG  1 
ATOM   1359 O OD1 . ASP   A 1 191 ? 15.33300  -24.48600 -9.77000  1.000 59.52723 ? 387 ASP   A OD1 1 
ATOM   1360 O OD2 . ASP   A 1 191 ? 16.65600  -24.28100 -8.01800  1.000 71.65623 ? 387 ASP   A OD2 1 
ATOM   1361 N N   . ARG   A 1 192 ? 17.71100  -19.72900 -8.19700  1.000 35.24277 ? 388 ARG   A N   1 
ATOM   1362 C CA  . ARG   A 1 192 ? 18.88600  -19.17800 -8.84200  1.000 35.47487 ? 388 ARG   A CA  1 
ATOM   1363 C C   . ARG   A 1 192 ? 20.12500  -19.39000 -7.97600  1.000 37.20078 ? 388 ARG   A C   1 
ATOM   1364 O O   . ARG   A 1 192 ? 20.03800  -19.34000 -6.74600  1.000 35.82073 ? 388 ARG   A O   1 
ATOM   1365 C CB  . ARG   A 1 192 ? 18.69900  -17.69000 -9.12400  1.000 34.90562 ? 388 ARG   A CB  1 
ATOM   1366 C CG  . ARG   A 1 192 ? 17.40900  -17.37800 -9.89300  1.000 30.60077 ? 388 ARG   A CG  1 
ATOM   1367 C CD  . ARG   A 1 192 ? 17.33800  -18.15100 -11.21700 1.000 30.25189 ? 388 ARG   A CD  1 
ATOM   1368 N NE  . ARG   A 1 192 ? 16.29700  -17.61000 -12.09200 1.000 26.61030 ? 388 ARG   A NE  1 
ATOM   1369 C CZ  . ARG   A 1 192 ? 15.95700  -18.10900 -13.27900 1.000 28.01569 ? 388 ARG   A CZ  1 
ATOM   1370 N NH1 . ARG   A 1 192 ? 16.55900  -19.17800 -13.78900 1.000 26.52264 ? 388 ARG   A NH1 1 
ATOM   1371 N NH2 . ARG   A 1 192 ? 14.99500  -17.51200 -13.98000 1.000 23.39854 ? 388 ARG   A NH2 1 
ATOM   1372 N N   . PRO   A 1 193 ? 21.28200  -19.62100 -8.59000  1.000 39.79254 ? 389 PRO   A N   1 
ATOM   1373 C CA  . PRO   A 1 193 ? 22.51700  -19.79500 -7.81600  1.000 40.88383 ? 389 PRO   A CA  1 
ATOM   1374 C C   . PRO   A 1 193 ? 22.93600  -18.50900 -7.11900  1.000 40.00587 ? 389 PRO   A C   1 
ATOM   1375 O O   . PRO   A 1 193 ? 22.86400  -17.41900 -7.68800  1.000 37.55437 ? 389 PRO   A O   1 
ATOM   1376 C CB  . PRO   A 1 193 ? 23.54400  -20.20500 -8.87800  1.000 42.45301 ? 389 PRO   A CB  1 
ATOM   1377 C CG  . PRO   A 1 193 ? 22.74600  -20.68500 -10.04000 1.000 44.39623 ? 389 PRO   A CG  1 
ATOM   1378 C CD  . PRO   A 1 193 ? 21.47900  -19.88600 -10.02200 1.000 39.33989 ? 389 PRO   A CD  1 
ATOM   1379 N N   . GLY   A 1 194 ? 23.39800  -18.64400 -5.88000  1.000 41.02649 ? 390 GLY   A N   1 
ATOM   1380 C CA  . GLY   A 1 194 ? 23.96100  -17.51100 -5.17700  1.000 35.37023 ? 390 GLY   A CA  1 
ATOM   1381 C C   . GLY   A 1 194 ? 22.98400  -16.64100 -4.42600  1.000 38.68600 ? 390 GLY   A C   1 
ATOM   1382 O O   . GLY   A 1 194 ? 23.39500  -15.61200 -3.88200  1.000 38.63653 ? 390 GLY   A O   1 
ATOM   1383 N N   . LEU   A 1 195 ? 21.70800  -17.00800 -4.37200  1.000 34.74320 ? 391 LEU   A N   1 
ATOM   1384 C CA  . LEU   A 1 195 ? 20.75800  -16.19900 -3.63200  1.000 37.62996 ? 391 LEU   A CA  1 
ATOM   1385 C C   . LEU   A 1 195 ? 21.08400  -16.21800 -2.14900  1.000 39.67273 ? 391 LEU   A C   1 
ATOM   1386 O O   . LEU   A 1 195 ? 21.40100  -17.26800 -1.58200  1.000 42.57506 ? 391 LEU   A O   1 
ATOM   1387 C CB  . LEU   A 1 195 ? 19.33700  -16.70200 -3.85200  1.000 37.53641 ? 391 LEU   A CB  1 
ATOM   1388 C CG  . LEU   A 1 195 ? 18.81000  -16.41200 -5.25700  1.000 34.98092 ? 391 LEU   A CG  1 
ATOM   1389 C CD1 . LEU   A 1 195 ? 17.49400  -17.14300 -5.42600  1.000 35.06948 ? 391 LEU   A CD1 1 
ATOM   1390 C CD2 . LEU   A 1 195 ? 18.63300  -14.91500 -5.45200  1.000 30.61745 ? 391 LEU   A CD2 1 
ATOM   1391 N N   . LEU   A 1 196 ? 21.00400  -15.04400 -1.52600  1.000 38.78137 ? 392 LEU   A N   1 
ATOM   1392 C CA  . LEU   A 1 196 ? 21.19800  -14.92000 -0.08600  1.000 42.87355 ? 392 LEU   A CA  1 
ATOM   1393 C C   . LEU   A 1 196 ? 19.93600  -15.24100 0.70200   1.000 46.19623 ? 392 LEU   A C   1 
ATOM   1394 O O   . LEU   A 1 196 ? 20.00600  -15.92800 1.72300   1.000 46.31542 ? 392 LEU   A O   1 
ATOM   1395 C CB  . LEU   A 1 196 ? 21.68000  -13.50900 0.26100   1.000 42.59462 ? 392 LEU   A CB  1 
ATOM   1396 C CG  . LEU   A 1 196 ? 23.00600  -13.07900 -0.37300  1.000 43.60288 ? 392 LEU   A CG  1 
ATOM   1397 C CD1 . LEU   A 1 196 ? 23.05400  -11.56500 -0.54800  1.000 42.61959 ? 392 LEU   A CD1 1 
ATOM   1398 C CD2 . LEU   A 1 196 ? 24.20600  -13.58900 0.42800   1.000 51.02277 ? 392 LEU   A CD2 1 
ATOM   1399 N N   . ASN   A 1 197 ? 18.77700  -14.76900 0.24300   1.000 42.25154 ? 393 ASN   A N   1 
ATOM   1400 C CA  . ASN   A 1 197 ? 17.54200  -14.89600 1.00200   1.000 43.15652 ? 393 ASN   A CA  1 
ATOM   1401 C C   . ASN   A 1 197 ? 16.56000  -15.82400 0.29200   1.000 42.26334 ? 393 ASN   A C   1 
ATOM   1402 O O   . ASN   A 1 197 ? 15.46100  -15.40300 -0.09200  1.000 39.80274 ? 393 ASN   A O   1 
ATOM   1403 C CB  . ASN   A 1 197 ? 16.91600  -13.51400 1.18900   1.000 46.77182 ? 393 ASN   A CB  1 
ATOM   1404 C CG  . ASN   A 1 197 ? 17.31800  -12.85700 2.49200   1.000 55.88623 ? 393 ASN   A CG  1 
ATOM   1405 O OD1 . ASN   A 1 197 ? 17.68600  -11.67900 2.50700   1.000 51.77323 ? 393 ASN   A OD1 1 
ATOM   1406 N ND2 . ASN   A 1 197 ? 17.23000  -13.59800 3.59300   1.000 53.78623 ? 393 ASN   A ND2 1 
ATOM   1407 N N   . VAL   A 1 198 ? 16.94700  -17.09200 0.13800   1.000 40.53729 ? 394 VAL   A N   1 
ATOM   1408 C CA  . VAL   A 1 198 ? 16.17800  -18.04400 -0.66000  1.000 42.52623 ? 394 VAL   A CA  1 
ATOM   1409 C C   . VAL   A 1 198 ? 14.73900  -18.14100 -0.16400  1.000 39.63315 ? 394 VAL   A C   1 
ATOM   1410 O O   . VAL   A 1 198 ? 13.79000  -18.14600 -0.96100  1.000 36.10508 ? 394 VAL   A O   1 
ATOM   1411 C CB  . VAL   A 1 198 ? 16.87700  -19.41800 -0.64900  1.000 41.26533 ? 394 VAL   A CB  1 
ATOM   1412 C CG1 . VAL   A 1 198 ? 16.00300  -20.47700 -1.29800  1.000 42.25122 ? 394 VAL   A CG1 1 
ATOM   1413 C CG2 . VAL   A 1 198 ? 18.23700  -19.32100 -1.33000  1.000 41.26577 ? 394 VAL   A CG2 1 
ATOM   1414 N N   . GLY   A 1 199 ? 14.54700  -18.21000 1.15400   1.000 36.89696 ? 395 GLY   A N   1 
ATOM   1415 C CA  . GLY   A 1 199 ? 13.20800  -18.43400 1.67600   1.000 36.66730 ? 395 GLY   A CA  1 
ATOM   1416 C C   . GLY   A 1 199 ? 12.24000  -17.31000 1.34600   1.000 36.70010 ? 395 GLY   A C   1 
ATOM   1417 O O   . GLY   A 1 199 ? 11.07500  -17.55400 1.03700   1.000 35.89038 ? 395 GLY   A O   1 
ATOM   1418 N N   . HIS   A 1 200 ? 12.70300  -16.06200 1.42300   1.000 33.84343 ? 396 HIS   A N   1 
ATOM   1419 C CA  . HIS   A 1 200 ? 11.81400  -14.93600 1.15700   1.000 34.69656 ? 396 HIS   A CA  1 
ATOM   1420 C C   . HIS   A 1 200 ? 11.42900  -14.88900 -0.32000  1.000 35.37885 ? 396 HIS   A C   1 
ATOM   1421 O O   . HIS   A 1 200 ? 10.29500  -14.53100 -0.66300  1.000 33.82370 ? 396 HIS   A O   1 
ATOM   1422 C CB  . HIS   A 1 200 ? 12.49100  -13.63100 1.58600   1.000 39.25589 ? 396 HIS   A CB  1 
ATOM   1423 C CG  . HIS   A 1 200 ? 12.56000  -13.44500 3.07300   1.000 39.37869 ? 396 HIS   A CG  1 
ATOM   1424 N ND1 . HIS   A 1 200 ? 13.33100  -12.46700 3.66900   1.000 45.72623 ? 396 HIS   A ND1 1 
ATOM   1425 C CD2 . HIS   A 1 200 ? 11.94300  -14.10200 4.08500   1.000 39.65088 ? 396 HIS   A CD2 1 
ATOM   1426 C CE1 . HIS   A 1 200 ? 13.20200  -12.54200 4.98300   1.000 40.67292 ? 396 HIS   A CE1 1 
ATOM   1427 N NE2 . HIS   A 1 200 ? 12.36000  -13.52100 5.26300   1.000 37.22940 ? 396 HIS   A NE2 1 
ATOM   1428 N N   . ILE   A 1 201 ? 12.38100  -15.21400 -1.20200  1.000 32.13819 ? 397 ILE   A N   1 
ATOM   1429 C CA  . ILE   A 1 201 ? 12.12400  -15.22500 -2.64500  1.000 30.94980 ? 397 ILE   A CA  1 
ATOM   1430 C C   . ILE   A 1 201 ? 11.16700  -16.35600 -3.00400  1.000 34.14348 ? 397 ILE   A C   1 
ATOM   1431 O O   . ILE   A 1 201 ? 10.25900  -16.18100 -3.82800  1.000 29.12093 ? 397 ILE   A O   1 
ATOM   1432 C CB  . ILE   A 1 201 ? 13.45500  -15.32200 -3.40800  1.000 35.93662 ? 397 ILE   A CB  1 
ATOM   1433 C CG1 . ILE   A 1 201 ? 14.22800  -14.02100 -3.20600  1.000 32.91464 ? 397 ILE   A CG1 1 
ATOM   1434 C CG2 . ILE   A 1 201 ? 13.22000  -15.57900 -4.90500  1.000 30.46521 ? 397 ILE   A CG2 1 
ATOM   1435 C CD1 . ILE   A 1 201 ? 15.65300  -14.07000 -3.64900  1.000 35.89599 ? 397 ILE   A CD1 1 
ATOM   1436 N N   . GLU   A 1 202 ? 11.34100  -17.52600 -2.37400  1.000 33.77536 ? 398 GLU   A N   1 
ATOM   1437 C CA  . GLU   A 1 202 ? 10.40900  -18.63700 -2.57100  1.000 34.63148 ? 398 GLU   A CA  1 
ATOM   1438 C C   . GLU   A 1 202 ? 8.97900   -18.23300 -2.23900  1.000 35.07497 ? 398 GLU   A C   1 
ATOM   1439 O O   . GLU   A 1 202 ? 8.04900   -18.55100 -2.98800  1.000 33.37464 ? 398 GLU   A O   1 
ATOM   1440 C CB  . GLU   A 1 202 ? 10.84200  -19.83800 -1.72700  1.000 38.31733 ? 398 GLU   A CB  1 
ATOM   1441 C CG  . GLU   A 1 202 ? 11.92600  -20.69500 -2.38700  1.000 41.38465 ? 398 GLU   A CG  1 
ATOM   1442 C CD  . GLU   A 1 202 ? 12.49900  -21.77900 -1.46800  1.000 51.49623 ? 398 GLU   A CD  1 
ATOM   1443 O OE1 . GLU   A 1 202 ? 12.00200  -21.95600 -0.33400  1.000 46.66803 ? 398 GLU   A OE1 1 
ATOM   1444 O OE2 . GLU   A 1 202 ? 13.44300  -22.47600 -1.89500  1.000 56.08623 ? 398 GLU   A OE2 1 
ATOM   1445 N N   . LYS   A 1 203 ? 8.77800   -17.53600 -1.11600  1.000 31.14941 ? 399 LYS   A N   1 
ATOM   1446 C CA  . LYS   A 1 203 ? 7.44100   -17.07500 -0.75100  1.000 30.58092 ? 399 LYS   A CA  1 
ATOM   1447 C C   . LYS   A 1 203 ? 6.89800   -16.06400 -1.75500  1.000 31.39838 ? 399 LYS   A C   1 
ATOM   1448 O O   . LYS   A 1 203 ? 5.70400   -16.08000 -2.07900  1.000 30.40420 ? 399 LYS   A O   1 
ATOM   1449 C CB  . LYS   A 1 203 ? 7.46300   -16.47100 0.65000   1.000 36.33417 ? 399 LYS   A CB  1 
ATOM   1450 C CG  . LYS   A 1 203 ? 7.95100   -17.44800 1.68800   1.000 41.44623 ? 399 LYS   A CG  1 
ATOM   1451 C CD  . LYS   A 1 203 ? 7.08200   -18.70000 1.71700   1.000 47.41623 ? 399 LYS   A CD  1 
ATOM   1452 C CE  . LYS   A 1 203 ? 7.43100   -19.57500 2.91900   1.000 50.45623 ? 399 LYS   A CE  1 
ATOM   1453 N NZ  . LYS   A 1 203 ? 8.80500   -19.31300 3.45000   1.000 42.55965 ? 399 LYS   A NZ  1 
ATOM   1454 N N   . MET   A 1 204 ? 7.74900   -15.15900 -2.22800  1.000 30.00369 ? 400 MET   A N   1 
ATOM   1455 C CA  . MET   A 1 204 ? 7.34500   -14.25600 -3.30100  1.000 32.19799 ? 400 MET   A CA  1 
ATOM   1456 C C   . MET   A 1 204 ? 6.88800   -15.02800 -4.53000  1.000 30.93284 ? 400 MET   A C   1 
ATOM   1457 O O   . MET   A 1 204 ? 5.83600   -14.73300 -5.11700  1.000 31.35410 ? 400 MET   A O   1 
ATOM   1458 C CB  . MET   A 1 204 ? 8.51000   -13.34700 -3.67000  1.000 32.76713 ? 400 MET   A CB  1 
ATOM   1459 C CG  . MET   A 1 204 ? 8.05900   -12.01200 -4.13400  1.000 43.59623 ? 400 MET   A CG  1 
ATOM   1460 S SD  . MET   A 1 204 ? 9.44800   -10.96700 -4.58400  1.000 43.97176 ? 400 MET   A SD  1 
ATOM   1461 C CE  . MET   A 1 204 ? 8.56800   -9.91100  -5.71900  1.000 35.66895 ? 400 MET   A CE  1 
ATOM   1462 N N   . GLN   A 1 205 ? 7.70300   -15.98800 -4.96000  1.000 29.79617 ? 401 GLN   A N   1 
ATOM   1463 C CA  . GLN   A 1 205 ? 7.38800   -16.77500 -6.14500  1.000 31.40138 ? 401 GLN   A CA  1 
ATOM   1464 C C   . GLN   A 1 205 ? 6.08100   -17.53200 -5.95900  1.000 31.65973 ? 401 GLN   A C   1 
ATOM   1465 O O   . GLN   A 1 205 ? 5.24800   -17.57900 -6.87200  1.000 30.99346 ? 401 GLN   A O   1 
ATOM   1466 C CB  . GLN   A 1 205 ? 8.54300   -17.73100 -6.43200  1.000 33.00630 ? 401 GLN   A CB  1 
ATOM   1467 C CG  . GLN   A 1 205 ? 8.27800   -18.76300 -7.52800  1.000 40.91623 ? 401 GLN   A CG  1 
ATOM   1468 C CD  . GLN   A 1 205 ? 8.89300   -20.10000 -7.20600  1.000 46.15847 ? 401 GLN   A CD  1 
ATOM   1469 O OE1 . GLN   A 1 205 ? 10.09900  -20.29400 -7.36500  1.000 50.59623 ? 401 GLN   A OE1 1 
ATOM   1470 N NE2 . GLN   A 1 205 ? 8.07000   -21.03600 -6.74200  1.000 58.44623 ? 401 GLN   A NE2 1 
ATOM   1471 N N   . GLU   A 1 206 ? 5.86400   -18.09400 -4.76700  1.000 33.42923 ? 402 GLU   A N   1 
ATOM   1472 C CA  . GLU   A 1 206 ? 4.63000   -18.82700 -4.51800  1.000 33.39895 ? 402 GLU   A CA  1 
ATOM   1473 C C   . GLU   A 1 206 ? 3.41300   -17.93300 -4.72100  1.000 29.48089 ? 402 GLU   A C   1 
ATOM   1474 O O   . GLU   A 1 206 ? 2.40900   -18.36900 -5.29600  1.000 29.46470 ? 402 GLU   A O   1 
ATOM   1475 C CB  . GLU   A 1 206 ? 4.64400   -19.43800 -3.10700  1.000 32.14831 ? 402 GLU   A CB  1 
ATOM   1476 C CG  . GLU   A 1 206 ? 3.31200   -20.08100 -2.68300  1.000 38.47349 ? 402 GLU   A CG  1 
ATOM   1477 C CD  . GLU   A 1 206 ? 3.19800   -20.24900 -1.16200  1.000 49.85623 ? 402 GLU   A CD  1 
ATOM   1478 O OE1 . GLU   A 1 206 ? 2.39100   -19.53900 -0.52300  1.000 47.69874 ? 402 GLU   A OE1 1 
ATOM   1479 O OE2 . GLU   A 1 206 ? 3.93500   -21.08700 -0.60300  1.000 50.92652 ? 402 GLU   A OE2 1 
ATOM   1480 N N   . GLY   A 1 207 ? 3.47900   -16.68100 -4.25800  1.000 26.52936 ? 403 GLY   A N   1 
ATOM   1481 C CA  . GLY   A 1 207 ? 2.36200   -15.78000 -4.47100  1.000 23.41984 ? 403 GLY   A CA  1 
ATOM   1482 C C   . GLY   A 1 207 ? 2.14100   -15.43800 -5.93600  1.000 25.08474 ? 403 GLY   A C   1 
ATOM   1483 O O   . GLY   A 1 207 ? 0.99700   -15.38100 -6.40800  1.000 26.36619 ? 403 GLY   A O   1 
ATOM   1484 N N   . ILE   A 1 208 ? 3.22600   -15.18900 -6.66800  1.000 25.83005 ? 404 ILE   A N   1 
ATOM   1485 C CA  . ILE   A 1 208 ? 3.07800   -14.85900 -8.08400  1.000 25.88578 ? 404 ILE   A CA  1 
ATOM   1486 C C   . ILE   A 1 208 ? 2.57200   -16.06900 -8.86300  1.000 23.97934 ? 404 ILE   A C   1 
ATOM   1487 O O   . ILE   A 1 208 ? 1.69400   -15.94500 -9.73300  1.000 27.68332 ? 404 ILE   A O   1 
ATOM   1488 C CB  . ILE   A 1 208 ? 4.41300   -14.33600 -8.64100  1.000 24.17836 ? 404 ILE   A CB  1 
ATOM   1489 C CG1 . ILE   A 1 208 ? 4.66800   -12.92700 -8.11200  1.000 27.03470 ? 404 ILE   A CG1 1 
ATOM   1490 C CG2 . ILE   A 1 208 ? 4.37500   -14.29900 -10.19500 1.000 28.62403 ? 404 ILE   A CG2 1 
ATOM   1491 C CD1 . ILE   A 1 208 ? 6.13600   -12.54100 -8.17500  1.000 30.51612 ? 404 ILE   A CD1 1 
ATOM   1492 N N   . VAL   A 1 209 ? 3.10000   -17.25700 -8.56100  1.000 25.38852 ? 405 VAL   A N   1 
ATOM   1493 C CA  . VAL   A 1 209 ? 2.63400   -18.44300 -9.28000  1.000 24.29026 ? 405 VAL   A CA  1 
ATOM   1494 C C   . VAL   A 1 209 ? 1.17300   -18.73800 -8.95200  1.000 28.42833 ? 405 VAL   A C   1 
ATOM   1495 O O   . VAL   A 1 209 ? 0.42500   -19.22700 -9.80600  1.000 28.14539 ? 405 VAL   A O   1 
ATOM   1496 C CB  . VAL   A 1 209 ? 3.56600   -19.63800 -8.97100  1.000 30.22589 ? 405 VAL   A CB  1 
ATOM   1497 C CG1 . VAL   A 1 209 ? 2.94900   -20.94700 -9.39200  1.000 31.96597 ? 405 VAL   A CG1 1 
ATOM   1498 C CG2 . VAL   A 1 209 ? 4.93300   -19.46000 -9.67700  1.000 26.34283 ? 405 VAL   A CG2 1 
ATOM   1499 N N   . HIS   A 1 210 ? 0.73400   -18.42200 -7.72900  1.000 26.73928 ? 406 HIS   A N   1 
ATOM   1500 C CA  . HIS   A 1 210 ? -0.65100  -18.63500 -7.35500  1.000 30.21739 ? 406 HIS   A CA  1 
ATOM   1501 C C   . HIS   A 1 210 ? -1.56300  -17.70800 -8.14900  1.000 28.73119 ? 406 HIS   A C   1 
ATOM   1502 O O   . HIS   A 1 210 ? -2.60700  -18.13500 -8.66200  1.000 28.02176 ? 406 HIS   A O   1 
ATOM   1503 C CB  . HIS   A 1 210 ? -0.78300  -18.41400 -5.84500  1.000 31.81071 ? 406 HIS   A CB  1 
ATOM   1504 C CG  . HIS   A 1 210 ? -2.17700  -18.56100 -5.32000  1.000 36.61590 ? 406 HIS   A CG  1 
ATOM   1505 N ND1 . HIS   A 1 210 ? -2.78900  -17.59700 -4.55200  1.000 43.31623 ? 406 HIS   A ND1 1 
ATOM   1506 C CD2 . HIS   A 1 210 ? -3.06500  -19.57800 -5.42300  1.000 46.12623 ? 406 HIS   A CD2 1 
ATOM   1507 C CE1 . HIS   A 1 210 ? -4.00300  -18.00100 -4.22300  1.000 43.96797 ? 406 HIS   A CE1 1 
ATOM   1508 N NE2 . HIS   A 1 210 ? -4.19400  -19.20200 -4.73600  1.000 42.97764 ? 406 HIS   A NE2 1 
ATOM   1509 N N   . VAL   A 1 211 ? -1.14400  -16.45100 -8.32400  1.000 25.65808 ? 407 VAL   A N   1 
ATOM   1510 C CA  . VAL   A 1 211 ? -1.92700  -15.49100 -9.11100  1.000 26.46210 ? 407 VAL   A CA  1 
ATOM   1511 C C   . VAL   A 1 211 ? -1.92400  -15.87800 -10.59500 1.000 25.98374 ? 407 VAL   A C   1 
ATOM   1512 O O   . VAL   A 1 211 ? -2.95500  -15.77300 -11.27900 1.000 26.45093 ? 407 VAL   A O   1 
ATOM   1513 C CB  . VAL   A 1 211 ? -1.38200  -14.07000 -8.86200  1.000 32.35592 ? 407 VAL   A CB  1 
ATOM   1514 C CG1 . VAL   A 1 211 ? -1.62800  -13.13900 -10.04000 1.000 38.43623 ? 407 VAL   A CG1 1 
ATOM   1515 C CG2 . VAL   A 1 211 ? -1.97700  -13.50900 -7.57100  1.000 34.89854 ? 407 VAL   A CG2 1 
ATOM   1516 N N   . LEU   A 1 212 ? -0.80400  -16.41100 -11.09100 1.000 26.46255 ? 408 LEU   A N   1 
ATOM   1517 C CA  . LEU   A 1 212 ? -0.75300  -16.91800 -12.46500 1.000 22.18906 ? 408 LEU   A CA  1 
ATOM   1518 C C   . LEU   A 1 212 ? -1.71900  -18.09000 -12.65700 1.000 23.20133 ? 408 LEU   A C   1 
ATOM   1519 O O   . LEU   A 1 212 ? -2.45100  -18.14900 -13.65700 1.000 21.90120 ? 408 LEU   A O   1 
ATOM   1520 C CB  . LEU   A 1 212 ? 0.68800   -17.34400 -12.82300 1.000 24.59913 ? 408 LEU   A CB  1 
ATOM   1521 C CG  . LEU   A 1 212 ? 0.94500   -18.10200 -14.14800 1.000 23.13655 ? 408 LEU   A CG  1 
ATOM   1522 C CD1 . LEU   A 1 212 ? 0.67500   -17.18800 -15.36800 1.000 21.13290 ? 408 LEU   A CD1 1 
ATOM   1523 C CD2 . LEU   A 1 212 ? 2.40600   -18.59100 -14.23700 1.000 24.75388 ? 408 LEU   A CD2 1 
ATOM   1524 N N   . ARG   A 1 213 ? -1.68800  -19.06700 -11.72800 1.000 24.99282 ? 409 ARG   A N   1 
ATOM   1525 C CA  . ARG   A 1 213 ? -2.59000  -20.22500 -11.78000 1.000 26.32471 ? 409 ARG   A CA  1 
ATOM   1526 C C   . ARG   A 1 213 ? -4.05200  -19.79300 -11.85600 1.000 24.64966 ? 409 ARG   A C   1 
ATOM   1527 O O   . ARG   A 1 213 ? -4.81300  -20.25900 -12.71200 1.000 25.27410 ? 409 ARG   A O   1 
ATOM   1528 C CB  . ARG   A 1 213 ? -2.37400  -21.10200 -10.53600 1.000 30.36516 ? 409 ARG   A CB  1 
ATOM   1529 C CG  . ARG   A 1 213 ? -2.92800  -22.50500 -10.63100 1.000 34.22261 ? 409 ARG   A CG  1 
ATOM   1530 C CD  . ARG   A 1 213 ? -2.52600  -23.37200 -9.42000  1.000 37.98319 ? 409 ARG   A CD  1 
ATOM   1531 N NE  . ARG   A 1 213 ? -2.09500  -22.59400 -8.26300  1.000 42.22623 ? 409 ARG   A NE  1 
ATOM   1532 C CZ  . ARG   A 1 213 ? -0.96300  -22.79500 -7.59400  1.000 50.16623 ? 409 ARG   A CZ  1 
ATOM   1533 N NH1 . ARG   A 1 213 ? -0.08000  -23.70400 -7.97800  1.000 46.18623 ? 409 ARG   A NH1 1 
ATOM   1534 N NH2 . ARG   A 1 213 ? -0.69800  -22.04500 -6.52700  1.000 51.99623 ? 409 ARG   A NH2 1 
ATOM   1535 N N   . LEU   A 1 214 ? -4.45600  -18.89900 -10.95300 1.000 27.38429 ? 410 LEU   A N   1 
ATOM   1536 C CA  . LEU   A 1 214 ? -5.83300  -18.41400 -10.93900 1.000 26.88622 ? 410 LEU   A CA  1 
ATOM   1537 C C   . LEU   A 1 214 ? -6.16900  -17.66000 -12.22000 1.000 27.21369 ? 410 LEU   A C   1 
ATOM   1538 O O   . LEU   A 1 214 ? -7.27000  -17.80300 -12.77900 1.000 26.33220 ? 410 LEU   A O   1 
ATOM   1539 C CB  . LEU   A 1 214 ? -6.02900  -17.51500 -9.72500  1.000 32.27036 ? 410 LEU   A CB  1 
ATOM   1540 C CG  . LEU   A 1 214 ? -6.71900  -18.08700 -8.48500  1.000 44.31623 ? 410 LEU   A CG  1 
ATOM   1541 C CD1 . LEU   A 1 214 ? -6.21500  -19.47300 -8.17800  1.000 39.55718 ? 410 LEU   A CD1 1 
ATOM   1542 C CD2 . LEU   A 1 214 ? -6.47200  -17.16300 -7.29900  1.000 40.98512 ? 410 LEU   A CD2 1 
ATOM   1543 N N   . HIS   A 1 215 ? -5.23800  -16.83200 -12.69300 1.000 21.68253 ? 411 HIS   A N   1 
ATOM   1544 C CA  . HIS   A 1 215 ? -5.48800  -16.06700 -13.90000 1.000 21.37080 ? 411 HIS   A CA  1 
ATOM   1545 C C   . HIS   A 1 215 ? -5.70700  -16.96500 -15.11500 1.000 24.76161 ? 411 HIS   A C   1 
ATOM   1546 O O   . HIS   A 1 215 ? -6.57500  -16.68500 -15.95100 1.000 22.12837 ? 411 HIS   A O   1 
ATOM   1547 C CB  . HIS   A 1 215 ? -4.31600  -15.12800 -14.16200 1.000 21.17227 ? 411 HIS   A CB  1 
ATOM   1548 C CG  . HIS   A 1 215 ? -4.51200  -14.27900 -15.36300 1.000 21.72456 ? 411 HIS   A CG  1 
ATOM   1549 N ND1 . HIS   A 1 215 ? -5.23900  -13.11000 -15.31900 1.000 27.70620 ? 411 HIS   A ND1 1 
ATOM   1550 C CD2 . HIS   A 1 215 ? -4.05100  -14.39700 -16.63200 1.000 25.34090 ? 411 HIS   A CD2 1 
ATOM   1551 C CE1 . HIS   A 1 215 ? -5.23400  -12.55300 -16.51800 1.000 30.60007 ? 411 HIS   A CE1 1 
ATOM   1552 N NE2 . HIS   A 1 215 ? -4.52400  -13.31700 -17.33100 1.000 24.87704 ? 411 HIS   A NE2 1 
ATOM   1553 N N   . LEU   A 1 216 ? -4.86600  -18.00000 -15.28900 1.000 23.32715 ? 412 LEU   A N   1 
ATOM   1554 C CA  . LEU   A 1 216 ? -5.03100  -18.89500 -16.43000 1.000 21.11656 ? 412 LEU   A CA  1 
ATOM   1555 C C   . LEU   A 1 216 ? -6.35900  -19.64700 -16.37500 1.000 23.06586 ? 412 LEU   A C   1 
ATOM   1556 O O   . LEU   A 1 216 ? -6.94700  -19.96800 -17.42000 1.000 23.66402 ? 412 LEU   A O   1 
ATOM   1557 C CB  . LEU   A 1 216 ? -3.85300  -19.87700 -16.46000 1.000 22.53657 ? 412 LEU   A CB  1 
ATOM   1558 C CG  . LEU   A 1 216 ? -2.47100  -19.22700 -16.66500 1.000 21.66029 ? 412 LEU   A CG  1 
ATOM   1559 C CD1 . LEU   A 1 216 ? -1.39000  -20.31400 -16.44700 1.000 23.10854 ? 412 LEU   A CD1 1 
ATOM   1560 C CD2 . LEU   A 1 216 ? -2.30000  -18.59900 -18.09300 1.000 20.52138 ? 412 LEU   A CD2 1 
ATOM   1561 N N   . GLN   A 1 217 ? -6.80700  -19.99500 -15.17000 1.000 24.70561 ? 413 GLN   A N   1 
ATOM   1562 C CA  . GLN   A 1 217 ? -8.07700  -20.69500 -15.05300 1.000 30.09029 ? 413 GLN   A CA  1 
ATOM   1563 C C   . GLN   A 1 217 ? -9.21700  -19.77600 -15.46800 1.000 23.17892 ? 413 GLN   A C   1 
ATOM   1564 O O   . GLN   A 1 217 ? -10.18300 -20.21900 -16.09800 1.000 32.24328 ? 413 GLN   A O   1 
ATOM   1565 C CB  . GLN   A 1 217 ? -8.25900  -21.21700 -13.62200 1.000 33.48922 ? 413 GLN   A CB  1 
ATOM   1566 C CG  . GLN   A 1 217 ? -9.70100  -21.24600 -13.13000 1.000 37.65385 ? 413 GLN   A CG  1 
ATOM   1567 C CD  . GLN   A 1 217 ? -9.79900  -21.27800 -11.61000 1.000 56.19623 ? 413 GLN   A CD  1 
ATOM   1568 O OE1 . GLN   A 1 217 ? -8.92000  -21.81200 -10.92100 1.000 47.41751 ? 413 GLN   A OE1 1 
ATOM   1569 N NE2 . GLN   A 1 217 ? -10.87200 -20.70000 -11.07900 1.000 53.76623 ? 413 GLN   A NE2 1 
ATOM   1570 N N   . SER   A 1 218 ? -9.09900  -18.49400 -15.14500 1.000 25.50168 ? 414 SER   A N   1 
ATOM   1571 C CA  . SER   A 1 218 ? -10.12000 -17.51200 -15.51000 1.000 26.10613 ? 414 SER   A CA  1 
ATOM   1572 C C   . SER   A 1 218 ? -10.05900 -17.18700 -16.99300 1.000 27.87647 ? 414 SER   A C   1 
ATOM   1573 O O   . SER   A 1 218 ? -11.09100 -17.08800 -17.67700 1.000 28.12423 ? 414 SER   A O   1 
ATOM   1574 C CB  . SER   A 1 218 ? -9.90300  -16.21500 -14.71800 1.000 31.94366 ? 414 SER   A CB  1 
ATOM   1575 O OG  . SER   A 1 218 ? -10.65900 -16.16300 -13.53700 1.000 40.13994 ? 414 SER   A OG  1 
ATOM   1576 N N   . ASN   A 1 219 ? -8.84800  -16.94900 -17.50000 1.000 22.96508 ? 415 ASN   A N   1 
ATOM   1577 C CA  . ASN   A 1 219 ? -8.66600  -16.40700 -18.83700 1.000 21.50593 ? 415 ASN   A CA  1 
ATOM   1578 C C   . ASN   A 1 219 ? -8.62900  -17.48200 -19.91800 1.000 20.52855 ? 415 ASN   A C   1 
ATOM   1579 O O   . ASN   A 1 219 ? -8.85200  -17.17800 -21.09700 1.000 22.77968 ? 415 ASN   A O   1 
ATOM   1580 C CB  . ASN   A 1 219 ? -7.36000  -15.57900 -18.87600 1.000 20.25412 ? 415 ASN   A CB  1 
ATOM   1581 C CG  . ASN   A 1 219 ? -7.31700  -14.60000 -20.03600 1.000 25.69067 ? 415 ASN   A CG  1 
ATOM   1582 O OD1 . ASN   A 1 219 ? -8.36100  -14.11100 -20.47500 1.000 25.81159 ? 415 ASN   A OD1 1 
ATOM   1583 N ND2 . ASN   A 1 219 ? -6.10600  -14.33200 -20.57200 1.000 23.93475 ? 415 ASN   A ND2 1 
ATOM   1584 N N   . HIS   A 1 220 ? -8.34100  -18.73500 -19.53600 1.000 20.70210 ? 416 HIS   A N   1 
ATOM   1585 C CA  . HIS   A 1 220 ? -8.24100  -19.86500 -20.46100 1.000 22.81334 ? 416 HIS   A CA  1 
ATOM   1586 C C   . HIS   A 1 220 ? -9.01400  -21.05900 -19.91400 1.000 26.53598 ? 416 HIS   A C   1 
ATOM   1587 O O   . HIS   A 1 220 ? -8.44800  -22.13000 -19.66100 1.000 23.63649 ? 416 HIS   A O   1 
ATOM   1588 C CB  . HIS   A 1 220 ? -6.77100  -20.24700 -20.67800 1.000 21.84345 ? 416 HIS   A CB  1 
ATOM   1589 C CG  . HIS   A 1 220 ? -5.99000  -19.19800 -21.39400 1.000 21.07809 ? 416 HIS   A CG  1 
ATOM   1590 N ND1 . HIS   A 1 220 ? -5.86100  -19.15300 -22.76600 1.000 26.42685 ? 416 HIS   A ND1 1 
ATOM   1591 C CD2 . HIS   A 1 220 ? -5.30600  -18.13500 -20.90800 1.000 21.70620 ? 416 HIS   A CD2 1 
ATOM   1592 C CE1 . HIS   A 1 220 ? -5.12900  -18.09900 -23.09500 1.000 23.29311 ? 416 HIS   A CE1 1 
ATOM   1593 N NE2 . HIS   A 1 220 ? -4.80100  -17.45600 -21.98400 1.000 21.37653 ? 416 HIS   A NE2 1 
ATOM   1594 N N   . PRO   A 1 221 ? -10.33600 -20.92600 -19.76900 1.000 26.09350 ? 417 PRO   A N   1 
ATOM   1595 C CA  . PRO   A 1 221 ? -11.11700 -22.04300 -19.22300 1.000 27.56024 ? 417 PRO   A CA  1 
ATOM   1596 C C   . PRO   A 1 221 ? -11.17200 -23.24000 -20.15000 1.000 26.27853 ? 417 PRO   A C   1 
ATOM   1597 O O   . PRO   A 1 221 ? -11.53800 -24.33600 -19.70300 1.000 33.72781 ? 417 PRO   A O   1 
ATOM   1598 C CB  . PRO   A 1 221 ? -12.50800 -21.41600 -19.02400 1.000 28.65758 ? 417 PRO   A CB  1 
ATOM   1599 C CG  . PRO   A 1 221 ? -12.60100 -20.39100 -20.09800 1.000 29.41481 ? 417 PRO   A CG  1 
ATOM   1600 C CD  . PRO   A 1 221 ? -11.19200 -19.82000 -20.25100 1.000 27.72426 ? 417 PRO   A CD  1 
ATOM   1601 N N   . ASP   A 1 222 ? -10.81100 -23.07000 -21.42100 1.000 24.04122 ? 418 ASP   A N   1 
ATOM   1602 C CA  . ASP   A 1 222 ? -10.79500 -24.12500 -22.41800 1.000 27.62435 ? 418 ASP   A CA  1 
ATOM   1603 C C   . ASP   A 1 222 ? -9.59000  -25.06400 -22.30500 1.000 29.96469 ? 418 ASP   A C   1 
ATOM   1604 O O   . ASP   A 1 222 ? -9.64800  -26.17000 -22.84400 1.000 34.30957 ? 418 ASP   A O   1 
ATOM   1605 C CB  . ASP   A 1 222 ? -10.82200 -23.48500 -23.80800 1.000 27.42916 ? 418 ASP   A CB  1 
ATOM   1606 C CG  . ASP   A 1 222 ? -9.70600  -22.42300 -24.01100 1.000 28.08686 ? 418 ASP   A CG  1 
ATOM   1607 O OD1 . ASP   A 1 222 ? -9.47200  -21.56900 -23.12900 1.000 30.22856 ? 418 ASP   A OD1 1 
ATOM   1608 O OD2 . ASP   A 1 222 ? -9.06200  -22.46300 -25.07400 1.000 37.93837 ? 418 ASP   A OD2 1 
ATOM   1609 N N   . ASP   A 1 223 ? -8.51700  -24.66200 -21.61800 1.000 27.21076 ? 419 ASP   A N   1 
ATOM   1610 C CA  . ASP   A 1 223 ? -7.23500  -25.40500 -21.60500 1.000 25.11858 ? 419 ASP   A CA  1 
ATOM   1611 C C   . ASP   A 1 223 ? -6.88200  -25.73600 -20.15800 1.000 26.39571 ? 419 ASP   A C   1 
ATOM   1612 O O   . ASP   A 1 223 ? -6.21300  -24.95600 -19.47600 1.000 24.39009 ? 419 ASP   A O   1 
ATOM   1613 C CB  . ASP   A 1 223 ? -6.10500  -24.57700 -22.30000 1.000 25.69481 ? 419 ASP   A CB  1 
ATOM   1614 C CG  . ASP   A 1 223 ? -4.79800  -25.36200 -22.46300 1.000 27.78424 ? 419 ASP   A CG  1 
ATOM   1615 O OD1 . ASP   A 1 223 ? -3.87700  -24.83600 -23.13900 1.000 26.57168 ? 419 ASP   A OD1 1 
ATOM   1616 O OD2 . ASP   A 1 223 ? -4.67000  -26.47500 -21.90800 1.000 29.96444 ? 419 ASP   A OD2 1 
ATOM   1617 N N   . ILE   A 1 224 ? -7.31500  -26.90400 -19.66800 1.000 25.79220 ? 420 ILE   A N   1 
ATOM   1618 C CA  . ILE   A 1 224 ? -7.16600  -27.13400 -18.23100 1.000 26.60752 ? 420 ILE   A CA  1 
ATOM   1619 C C   . ILE   A 1 224 ? -5.75000  -27.52200 -17.83800 1.000 24.07013 ? 420 ILE   A C   1 
ATOM   1620 O O   . ILE   A 1 224 ? -5.44000  -27.53600 -16.64900 1.000 28.37572 ? 420 ILE   A O   1 
ATOM   1621 C CB  . ILE   A 1 224 ? -8.12300  -28.20800 -17.66600 1.000 30.75292 ? 420 ILE   A CB  1 
ATOM   1622 C CG1 . ILE   A 1 224 ? -7.77400  -29.58000 -18.22700 1.000 34.61884 ? 420 ILE   A CG1 1 
ATOM   1623 C CG2 . ILE   A 1 224 ? -9.57300  -27.82200 -17.94200 1.000 35.94283 ? 420 ILE   A CG2 1 
ATOM   1624 C CD1 . ILE   A 1 224 ? -8.72600  -30.69300 -17.80300 1.000 35.28115 ? 420 ILE   A CD1 1 
ATOM   1625 N N   . PHE   A 1 225 ? -4.86400  -27.75100 -18.80900 1.000 22.98251 ? 421 PHE   A N   1 
ATOM   1626 C CA  . PHE   A 1 225 ? -3.47500  -28.04400 -18.51200 1.000 22.02624 ? 421 PHE   A CA  1 
ATOM   1627 C C   . PHE   A 1 225 ? -2.56900  -26.87100 -18.83400 1.000 24.26340 ? 421 PHE   A C   1 
ATOM   1628 O O   . PHE   A 1 225 ? -1.35000  -27.04800 -18.91600 1.000 22.10424 ? 421 PHE   A O   1 
ATOM   1629 C CB  . PHE   A 1 225 ? -3.03700  -29.28400 -19.29100 1.000 25.26891 ? 421 PHE   A CB  1 
ATOM   1630 C CG  . PHE   A 1 225 ? -3.52100  -30.54400 -18.66700 1.000 28.49420 ? 421 PHE   A CG  1 
ATOM   1631 C CD1 . PHE   A 1 225 ? -4.78400  -31.03400 -18.95200 1.000 33.45499 ? 421 PHE   A CD1 1 
ATOM   1632 C CD2 . PHE   A 1 225 ? -2.77100  -31.18100 -17.71100 1.000 29.70421 ? 421 PHE   A CD2 1 
ATOM   1633 C CE1 . PHE   A 1 225 ? -5.24400  -32.20000 -18.33300 1.000 33.38422 ? 421 PHE   A CE1 1 
ATOM   1634 C CE2 . PHE   A 1 225 ? -3.21700  -32.33600 -17.09700 1.000 33.99399 ? 421 PHE   A CE2 1 
ATOM   1635 C CZ  . PHE   A 1 225 ? -4.44900  -32.84300 -17.40500 1.000 31.58904 ? 421 PHE   A CZ  1 
ATOM   1636 N N   . LEU   A 1 226 ? -3.12600  -25.67300 -19.04000 1.000 20.04493 ? 422 LEU   A N   1 
ATOM   1637 C CA  . LEU   A 1 226 ? -2.25300  -24.58500 -19.47700 1.000 22.37576 ? 422 LEU   A CA  1 
ATOM   1638 C C   . LEU   A 1 226 ? -1.18900  -24.26100 -18.41200 1.000 19.13749 ? 422 LEU   A C   1 
ATOM   1639 O O   . LEU   A 1 226 ? -0.04100  -23.94300 -18.75500 1.000 18.27182 ? 422 LEU   A O   1 
ATOM   1640 C CB  . LEU   A 1 226 ? -3.07900  -23.35000 -19.83800 1.000 21.61283 ? 422 LEU   A CB  1 
ATOM   1641 C CG  . LEU   A 1 226 ? -2.24000  -22.17600 -20.38900 1.000 19.37882 ? 422 LEU   A CG  1 
ATOM   1642 C CD1 . LEU   A 1 226 ? -1.39400  -22.55200 -21.60400 1.000 18.70532 ? 422 LEU   A CD1 1 
ATOM   1643 C CD2 . LEU   A 1 226 ? -3.21600  -21.03700 -20.74500 1.000 20.43921 ? 422 LEU   A CD2 1 
ATOM   1644 N N   . PHE   A 1 227 ? -1.53900  -24.31300 -17.12200 1.000 21.05824 ? 423 PHE   A N   1 
ATOM   1645 C CA  . PHE   A 1 227 ? -0.54800  -23.99400 -16.09200 1.000 19.18208 ? 423 PHE   A CA  1 
ATOM   1646 C C   . PHE   A 1 227 ? 0.60800   -24.98900 -16.10400 1.000 18.97204 ? 423 PHE   A C   1 
ATOM   1647 O O   . PHE   A 1 227 ? 1.77000   -24.54600 -16.21100 1.000 18.06614 ? 423 PHE   A O   1 
ATOM   1648 C CB  . PHE   A 1 227 ? -1.24600  -23.88500 -14.71500 1.000 22.12671 ? 423 PHE   A CB  1 
ATOM   1649 C CG  . PHE   A 1 227 ? -0.30300  -23.66000 -13.58300 1.000 21.61347 ? 423 PHE   A CG  1 
ATOM   1650 C CD1 . PHE   A 1 227 ? 0.46900   -22.49700 -13.52400 1.000 25.64811 ? 423 PHE   A CD1 1 
ATOM   1651 C CD2 . PHE   A 1 227 ? -0.11400  -24.62800 -12.59400 1.000 26.69022 ? 423 PHE   A CD2 1 
ATOM   1652 C CE1 . PHE   A 1 227 ? 1.39200   -22.28000 -12.48700 1.000 26.91149 ? 423 PHE   A CE1 1 
ATOM   1653 C CE2 . PHE   A 1 227 ? 0.81100   -24.41700 -11.55000 1.000 26.23368 ? 423 PHE   A CE2 1 
ATOM   1654 C CZ  . PHE   A 1 227 ? 1.56400   -23.25900 -11.50300 1.000 26.60589 ? 423 PHE   A CZ  1 
ATOM   1655 N N   . PRO   A 1 228 ? 0.39300   -26.31100 -16.08100 1.000 18.19178 ? 424 PRO   A N   1 
ATOM   1656 C CA  . PRO   A 1 228 ? 1.57500   -27.19500 -16.18900 1.000 18.93602 ? 424 PRO   A CA  1 
ATOM   1657 C C   . PRO   A 1 228 ? 2.30800   -27.06600 -17.52700 1.000 19.09796 ? 424 PRO   A C   1 
ATOM   1658 O O   . PRO   A 1 228 ? 3.53200   -27.25600 -17.54600 1.000 19.90630 ? 424 PRO   A O   1 
ATOM   1659 C CB  . PRO   A 1 228 ? 1.01800   -28.61400 -15.98400 1.000 23.33831 ? 424 PRO   A CB  1 
ATOM   1660 C CG  . PRO   A 1 228 ? -0.47100  -28.48400 -15.97300 1.000 25.41037 ? 424 PRO   A CG  1 
ATOM   1661 C CD  . PRO   A 1 228 ? -0.81500  -27.05200 -15.65900 1.000 24.19422 ? 424 PRO   A CD  1 
ATOM   1662 N N   . LYS   A 1 229 ? 1.62600   -26.71900 -18.63500 1.000 17.64840 ? 425 LYS   A N   1 
ATOM   1663 C CA  . LYS   A 1 229 ? 2.34400   -26.46700 -19.89300 1.000 15.84046 ? 425 LYS   A CA  1 
ATOM   1664 C C   . LYS   A 1 229 ? 3.29900   -25.30400 -19.72800 1.000 17.21470 ? 425 LYS   A C   1 
ATOM   1665 O O   . LYS   A 1 229 ? 4.43900   -25.36000 -20.20400 1.000 18.18941 ? 425 LYS   A O   1 
ATOM   1666 C CB  . LYS   A 1 229 ? 1.38000   -26.12200 -21.03900 1.000 17.41887 ? 425 LYS   A CB  1 
ATOM   1667 C CG  . LYS   A 1 229 ? 0.43200   -27.22100 -21.52100 1.000 22.26439 ? 425 LYS   A CG  1 
ATOM   1668 C CD  . LYS   A 1 229 ? -0.48300  -26.63900 -22.64900 1.000 22.91247 ? 425 LYS   A CD  1 
ATOM   1669 C CE  . LYS   A 1 229 ? -1.57600  -27.62800 -23.01300 1.000 28.08062 ? 425 LYS   A CE  1 
ATOM   1670 N NZ  . LYS   A 1 229 ? -2.49800  -27.09900 -24.09300 1.000 25.42601 ? 425 LYS   A NZ  1 
ATOM   1671 N N   . LEU   A 1 230 ? 2.85500   -24.24400 -19.03800 1.000 19.12858 ? 426 LEU   A N   1 
ATOM   1672 C CA  . LEU   A 1 230 ? 3.72700   -23.08900 -18.84900 1.000 18.97946 ? 426 LEU   A CA  1 
ATOM   1673 C C   . LEU   A 1 230 ? 4.86400   -23.39300 -17.87800 1.000 17.66311 ? 426 LEU   A C   1 
ATOM   1674 O O   . LEU   A 1 230 ? 5.97600   -22.88400 -18.06600 1.000 19.37870 ? 426 LEU   A O   1 
ATOM   1675 C CB  . LEU   A 1 230 ? 2.91500   -21.86500 -18.39000 1.000 18.80183 ? 426 LEU   A CB  1 
ATOM   1676 C CG  . LEU   A 1 230 ? 2.14900   -21.23000 -19.54200 1.000 21.97405 ? 426 LEU   A CG  1 
ATOM   1677 C CD1 . LEU   A 1 230 ? 1.30500   -20.12800 -18.94600 1.000 27.67693 ? 426 LEU   A CD1 1 
ATOM   1678 C CD2 . LEU   A 1 230 ? 3.07700   -20.67300 -20.63400 1.000 24.23475 ? 426 LEU   A CD2 1 
ATOM   1679 N N   . LEU   A 1 231 ? 4.63700   -24.22400 -16.84800 1.000 19.61657 ? 427 LEU   A N   1 
ATOM   1680 C CA  . LEU   A 1 231 ? 5.77000   -24.65500 -16.02200 1.000 20.00482 ? 427 LEU   A CA  1 
ATOM   1681 C C   . LEU   A 1 231 ? 6.81200   -25.36300 -16.88000 1.000 20.15471 ? 427 LEU   A C   1 
ATOM   1682 O O   . LEU   A 1 231 ? 8.02000   -25.15200 -16.71700 1.000 20.01818 ? 427 LEU   A O   1 
ATOM   1683 C CB  . LEU   A 1 231 ? 5.29200   -25.58400 -14.91000 1.000 19.59848 ? 427 LEU   A CB  1 
ATOM   1684 C CG  . LEU   A 1 231 ? 4.39700   -24.94000 -13.84700 1.000 21.62667 ? 427 LEU   A CG  1 
ATOM   1685 C CD1 . LEU   A 1 231 ? 3.97600   -25.98700 -12.83800 1.000 26.49012 ? 427 LEU   A CD1 1 
ATOM   1686 C CD2 . LEU   A 1 231 ? 5.13900   -23.82500 -13.15200 1.000 26.25598 ? 427 LEU   A CD2 1 
ATOM   1687 N N   . GLN   A 1 232 ? 6.36400   -26.19400 -17.81500 1.000 17.09489 ? 428 GLN   A N   1 
ATOM   1688 C CA  . GLN   A 1 232 ? 7.31800   -26.86500 -18.69200 1.000 18.67087 ? 428 GLN   A CA  1 
ATOM   1689 C C   . GLN   A 1 232 ? 8.03400   -25.87400 -19.61300 1.000 20.56033 ? 428 GLN   A C   1 
ATOM   1690 O O   . GLN   A 1 232 ? 9.24500   -25.99800 -19.84300 1.000 22.05202 ? 428 GLN   A O   1 
ATOM   1691 C CB  . GLN   A 1 232 ? 6.60400   -27.95100 -19.49200 1.000 21.06652 ? 428 GLN   A CB  1 
ATOM   1692 C CG  . GLN   A 1 232 ? 7.58400   -28.70100 -20.42300 1.000 21.85334 ? 428 GLN   A CG  1 
ATOM   1693 C CD  . GLN   A 1 232 ? 6.86300   -29.66000 -21.34200 1.000 22.34880 ? 428 GLN   A CD  1 
ATOM   1694 O OE1 . GLN   A 1 232 ? 6.06600   -29.25300 -22.18300 1.000 25.15736 ? 428 GLN   A OE1 1 
ATOM   1695 N NE2 . GLN   A 1 232 ? 7.16100   -30.94000 -21.20400 1.000 25.83997 ? 428 GLN   A NE2 1 
ATOM   1696 N N   . LYS   A 1 233 ? 7.31900   -24.85200 -20.10700 1.000 18.82062 ? 429 LYS   A N   1 
ATOM   1697 C CA  . LYS   A 1 233 ? 7.98500   -23.84300 -20.92800 1.000 18.11777 ? 429 LYS   A CA  1 
ATOM   1698 C C   . LYS   A 1 233 ? 9.05600   -23.11500 -20.13600 1.000 20.54369 ? 429 LYS   A C   1 
ATOM   1699 O O   . LYS   A 1 233 ? 10.06400  -22.69700 -20.71500 1.000 19.76691 ? 429 LYS   A O   1 
ATOM   1700 C CB  . LYS   A 1 233 ? 6.95600   -22.82600 -21.46000 1.000 20.50444 ? 429 LYS   A CB  1 
ATOM   1701 C CG  . LYS   A 1 233 ? 5.90700   -23.38700 -22.43100 1.000 21.23414 ? 429 LYS   A CG  1 
ATOM   1702 C CD  . LYS   A 1 233 ? 6.54300   -23.97500 -23.66900 1.000 23.94450 ? 429 LYS   A CD  1 
ATOM   1703 C CE  . LYS   A 1 233 ? 5.45000   -24.42500 -24.64900 1.000 27.54628 ? 429 LYS   A CE  1 
ATOM   1704 N NZ  . LYS   A 1 233 ? 5.97500   -25.50000 -25.51200 1.000 24.91908 ? 429 LYS   A NZ  1 
ATOM   1705 N N   . MET   A 1 234 ? 8.85100   -22.91500 -18.82900 1.000 20.31063 ? 430 MET   A N   1 
ATOM   1706 C CA  . MET   A 1 234 ? 9.88800   -22.25700 -18.03700 1.000 19.21998 ? 430 MET   A CA  1 
ATOM   1707 C C   . MET   A 1 234 ? 11.15200  -23.11500 -18.01500 1.000 22.59565 ? 430 MET   A C   1 
ATOM   1708 O O   . MET   A 1 234 ? 12.27700  -22.60200 -18.13100 1.000 23.10233 ? 430 MET   A O   1 
ATOM   1709 C CB  . MET   A 1 234 ? 9.38000   -21.99100 -16.61200 1.000 23.12695 ? 430 MET   A CB  1 
ATOM   1710 C CG  . MET   A 1 234 ? 8.17400   -21.07400 -16.49300 1.000 26.49723 ? 430 MET   A CG  1 
ATOM   1711 S SD  . MET   A 1 234 ? 7.66200   -20.80800 -14.74900 1.000 32.07592 ? 430 MET   A SD  1 
ATOM   1712 C CE  . MET   A 1 234 ? 9.08600   -19.87300 -14.19500 1.000 31.78316 ? 430 MET   A CE  1 
ATOM   1713 N N   . ALA   A 1 235 ? 10.98300  -24.42700 -17.84700 1.000 22.46045 ? 431 ALA   A N   1 
ATOM   1714 C CA  . ALA   A 1 235 ? 12.12600  -25.33800 -17.88900 1.000 22.14035 ? 431 ALA   A CA  1 
ATOM   1715 C C   . ALA   A 1 235 ? 12.78000  -25.35500 -19.26700 1.000 23.08495 ? 431 ALA   A C   1 
ATOM   1716 O O   . ALA   A 1 235 ? 14.01300  -25.35900 -19.37700 1.000 24.61064 ? 431 ALA   A O   1 
ATOM   1717 C CB  . ALA   A 1 235 ? 11.66600  -26.74100 -17.48600 1.000 22.13202 ? 431 ALA   A CB  1 
ATOM   1718 N N   . ASP   A 1 236 ? 11.97400  -25.34100 -20.32600 1.000 19.96676 ? 432 ASP   A N   1 
ATOM   1719 C CA  . ASP   A 1 236 ? 12.50700  -25.28300 -21.68100 1.000 19.79669 ? 432 ASP   A CA  1 
ATOM   1720 C C   . ASP   A 1 236 ? 13.31900  -24.01100 -21.89500 1.000 24.15362 ? 432 ASP   A C   1 
ATOM   1721 O O   . ASP   A 1 236 ? 14.34900  -24.02600 -22.58100 1.000 20.74826 ? 432 ASP   A O   1 
ATOM   1722 C CB  . ASP   A 1 236 ? 11.37700  -25.36000 -22.71000 1.000 20.79443 ? 432 ASP   A CB  1 
ATOM   1723 C CG  . ASP   A 1 236 ? 10.64500  -26.68600 -22.70700 1.000 26.95575 ? 432 ASP   A CG  1 
ATOM   1724 O OD1 . ASP   A 1 236 ? 11.12000  -27.67200 -22.10700 1.000 29.02707 ? 432 ASP   A OD1 1 
ATOM   1725 O OD2 . ASP   A 1 236 ? 9.56100   -26.71300 -23.32400 1.000 30.36367 ? 432 ASP   A OD2 1 
ATOM   1726 N N   . LEU   A 1 237 ? 12.83500  -22.88300 -21.36900 1.000 20.71883 ? 433 LEU   A N   1 
ATOM   1727 C CA  . LEU   A 1 237 ? 13.54400  -21.61600 -21.52300 1.000 17.61520 ? 433 LEU   A CA  1 
ATOM   1728 C C   . LEU   A 1 237 ? 14.88700  -21.65200 -20.81500 1.000 22.39086 ? 433 LEU   A C   1 
ATOM   1729 O O   . LEU   A 1 237 ? 15.87000  -21.08300 -21.31700 1.000 19.26980 ? 433 LEU   A O   1 
ATOM   1730 C CB  . LEU   A 1 237 ? 12.69900  -20.45600 -20.96700 1.000 18.17582 ? 433 LEU   A CB  1 
ATOM   1731 C CG  . LEU   A 1 237 ? 11.60100  -20.01200 -21.94100 1.000 19.03616 ? 433 LEU   A CG  1 
ATOM   1732 C CD1 . LEU   A 1 237 ? 10.52700  -19.18400 -21.17200 1.000 18.27568 ? 433 LEU   A CD1 1 
ATOM   1733 C CD2 . LEU   A 1 237 ? 12.21000  -19.21400 -23.08700 1.000 21.68998 ? 433 LEU   A CD2 1 
ATOM   1734 N N   . ARG   A 1 238 ? 14.94600  -22.29500 -19.63800 1.000 19.64663 ? 434 ARG   A N   1 
ATOM   1735 C CA  . ARG   A 1 238 ? 16.23600  -22.44100 -18.94400 1.000 21.03479 ? 434 ARG   A CA  1 
ATOM   1736 C C   . ARG   A 1 238 ? 17.24100  -23.19400 -19.81400 1.000 22.00267 ? 434 ARG   A C   1 
ATOM   1737 O O   . ARG   A 1 238 ? 18.40100  -22.77000 -19.95100 1.000 22.61871 ? 434 ARG   A O   1 
ATOM   1738 C CB  . ARG   A 1 238 ? 16.03700  -23.14900 -17.61000 1.000 24.24936 ? 434 ARG   A CB  1 
ATOM   1739 C CG  . ARG   A 1 238 ? 17.24000  -23.05900 -16.67700 1.000 33.68483 ? 434 ARG   A CG  1 
ATOM   1740 C CD  . ARG   A 1 238 ? 16.85900  -23.64300 -15.32800 1.000 36.69965 ? 434 ARG   A CD  1 
ATOM   1741 N NE  . ARG   A 1 238 ? 15.99800  -22.76100 -14.54400 1.000 34.10709 ? 434 ARG   A NE  1 
ATOM   1742 C CZ  . ARG   A 1 238 ? 15.82500  -22.88600 -13.23100 1.000 38.59974 ? 434 ARG   A CZ  1 
ATOM   1743 N NH1 . ARG   A 1 238 ? 16.41500  -23.85500 -12.55200 1.000 39.27280 ? 434 ARG   A NH1 1 
ATOM   1744 N NH2 . ARG   A 1 238 ? 15.05300  -22.01300 -12.58300 1.000 35.72470 ? 434 ARG   A NH2 1 
ATOM   1745 N N   . GLN   A 1 239 ? 16.80900  -24.28800 -20.45500 1.000 23.12880 ? 435 GLN   A N   1 
ATOM   1746 C CA  . GLN   A 1 239 ? 17.72200  -25.02400 -21.32900 1.000 22.68371 ? 435 GLN   A CA  1 
ATOM   1747 C C   . GLN   A 1 239 ? 18.06400  -24.23400 -22.58900 1.000 24.08378 ? 435 GLN   A C   1 
ATOM   1748 O O   . GLN   A 1 239 ? 19.19800  -24.30600 -23.09400 1.000 24.31671 ? 435 GLN   A O   1 
ATOM   1749 C CB  . GLN   A 1 239 ? 17.11400  -26.38000 -21.66000 1.000 28.62475 ? 435 GLN   A CB  1 
ATOM   1750 C CG  . GLN   A 1 239 ? 17.92900  -27.18600 -22.62200 1.000 29.53773 ? 435 GLN   A CG  1 
ATOM   1751 C CD  . GLN   A 1 239 ? 19.14400  -27.76200 -21.91500 1.000 39.47623 ? 435 GLN   A CD  1 
ATOM   1752 O OE1 . GLN   A 1 239 ? 19.15400  -27.88800 -20.68300 1.000 36.73509 ? 435 GLN   A OE1 1 
ATOM   1753 N NE2 . GLN   A 1 239 ? 20.18700  -28.08300 -22.68200 1.000 42.62623 ? 435 GLN   A NE2 1 
ATOM   1754 N N   . LEU   A 1 240 ? 17.10900  -23.46400 -23.11200 1.000 20.41987 ? 436 LEU   A N   1 
ATOM   1755 C CA  . LEU   A 1 240 ? 17.38200  -22.63300 -24.26900 1.000 19.26096 ? 436 LEU   A CA  1 
ATOM   1756 C C   . LEU   A 1 240 ? 18.46700  -21.61000 -23.96700 1.000 21.16050 ? 436 LEU   A C   1 
ATOM   1757 O O   . LEU   A 1 240 ? 19.29200  -21.30500 -24.83700 1.000 21.89360 ? 436 LEU   A O   1 
ATOM   1758 C CB  . LEU   A 1 240 ? 16.07200  -21.93900 -24.70500 1.000 19.57704 ? 436 LEU   A CB  1 
ATOM   1759 C CG  . LEU   A 1 240 ? 15.95900  -21.31900 -26.08700 1.000 23.13386 ? 436 LEU   A CG  1 
ATOM   1760 C CD1 . LEU   A 1 240 ? 15.99800  -22.42400 -27.14100 1.000 29.28614 ? 436 LEU   A CD1 1 
ATOM   1761 C CD2 . LEU   A 1 240 ? 14.62200  -20.49400 -26.21000 1.000 26.64153 ? 436 LEU   A CD2 1 
ATOM   1762 N N   . VAL   A 1 241 ? 18.41900  -21.01200 -22.77700 1.000 20.05571 ? 437 VAL   A N   1 
ATOM   1763 C CA  . VAL   A 1 241 ? 19.37200  -19.97100 -22.41200 1.000 20.89758 ? 437 VAL   A CA  1 
ATOM   1764 C C   . VAL   A 1 241 ? 20.74400  -20.59400 -22.19800 1.000 25.40476 ? 437 VAL   A C   1 
ATOM   1765 O O   . VAL   A 1 241 ? 21.75800  -20.02700 -22.61800 1.000 24.48948 ? 437 VAL   A O   1 
ATOM   1766 C CB  . VAL   A 1 241 ? 18.87100  -19.19400 -21.17200 1.000 21.75451 ? 437 VAL   A CB  1 
ATOM   1767 C CG1 . VAL   A 1 241 ? 19.97200  -18.29100 -20.62300 1.000 25.05913 ? 437 VAL   A CG1 1 
ATOM   1768 C CG2 . VAL   A 1 241 ? 17.64100  -18.32800 -21.54600 1.000 21.83314 ? 437 VAL   A CG2 1 
ATOM   1769 N N   . THR   A 1 242 ? 20.78600  -21.77800 -21.57600 1.000 22.12311 ? 438 THR   A N   1 
ATOM   1770 C CA  . THR   A 1 242 ? 22.07500  -22.46400 -21.35700 1.000 24.37978 ? 438 THR   A CA  1 
ATOM   1771 C C   . THR   A 1 242 ? 22.77700  -22.72000 -22.67900 1.000 27.94221 ? 438 THR   A C   1 
ATOM   1772 O O   . THR   A 1 242 ? 23.98600  -22.46000 -22.83000 1.000 26.86957 ? 438 THR   A O   1 
ATOM   1773 C CB  . THR   A 1 242 ? 21.85100  -23.77900 -20.60100 1.000 26.25945 ? 438 THR   A CB  1 
ATOM   1774 O OG1 . THR   A 1 242 ? 21.18500  -23.52300 -19.36600 1.000 31.49301 ? 438 THR   A OG1 1 
ATOM   1775 C CG2 . THR   A 1 242 ? 23.20300  -24.46400 -20.30200 1.000 31.61274 ? 438 THR   A CG2 1 
ATOM   1776 N N   . GLU   A 1 243 ? 22.03900  -23.24900 -23.64900 1.000 22.77272 ? 439 GLU   A N   1 
ATOM   1777 C CA  . GLU   A 1 243 ? 22.57500  -23.47900 -24.98500 1.000 24.69302 ? 439 GLU   A CA  1 
ATOM   1778 C C   . GLU   A 1 243 ? 22.94500  -22.18000 -25.69100 1.000 27.47577 ? 439 GLU   A C   1 
ATOM   1779 O O   . GLU   A 1 243 ? 23.96800  -22.12100 -26.39400 1.000 26.33812 ? 439 GLU   A O   1 
ATOM   1780 C CB  . GLU   A 1 243 ? 21.55800  -24.28000 -25.79900 1.000 25.42229 ? 439 GLU   A CB  1 
ATOM   1781 C CG  . GLU   A 1 243 ? 21.46800  -25.70500 -25.30100 1.000 28.56376 ? 439 GLU   A CG  1 
ATOM   1782 C CD  . GLU   A 1 243 ? 20.20200  -26.40900 -25.70700 1.000 33.20701 ? 439 GLU   A CD  1 
ATOM   1783 O OE1 . GLU   A 1 243 ? 19.36300  -25.79700 -26.40500 1.000 37.97308 ? 439 GLU   A OE1 1 
ATOM   1784 O OE2 . GLU   A 1 243 ? 20.04700  -27.58500 -25.32200 1.000 36.25201 ? 439 GLU   A OE2 1 
ATOM   1785 N N   . HIS   A 1 244 ? 22.11600  -21.13500 -25.55300 1.000 22.36018 ? 440 HIS   A N   1 
ATOM   1786 C CA  . HIS   A 1 244 ? 22.45500  -19.84300 -26.12800 1.000 20.56628 ? 440 HIS   A CA  1 
ATOM   1787 C C   . HIS   A 1 244 ? 23.78100  -19.31300 -25.56700 1.000 27.30321 ? 440 HIS   A C   1 
ATOM   1788 O O   . HIS   A 1 244 ? 24.60900  -18.79300 -26.31800 1.000 24.35933 ? 440 HIS   A O   1 
ATOM   1789 C CB  . HIS   A 1 244 ? 21.31500  -18.84600 -25.85800 1.000 21.94329 ? 440 HIS   A CB  1 
ATOM   1790 C CG  . HIS   A 1 244 ? 21.51200  -17.51800 -26.51000 1.000 18.27329 ? 440 HIS   A CG  1 
ATOM   1791 N ND1 . HIS   A 1 244 ? 21.41900  -17.33500 -27.86800 1.000 21.97623 ? 440 HIS   A ND1 1 
ATOM   1792 C CD2 . HIS   A 1 244 ? 21.86700  -16.31800 -25.99700 1.000 20.47078 ? 440 HIS   A CD2 1 
ATOM   1793 C CE1 . HIS   A 1 244 ? 21.64000  -16.07200 -28.16200 1.000 21.86643 ? 440 HIS   A CE1 1 
ATOM   1794 N NE2 . HIS   A 1 244 ? 21.91900  -15.43400 -27.04400 1.000 22.22094 ? 440 HIS   A NE2 1 
ATOM   1795 N N   . ALA   A 1 245 ? 23.99200  -19.45200 -24.25900 1.000 22.95462 ? 441 ALA   A N   1 
ATOM   1796 C CA  . ALA   A 1 245 ? 25.21800  -18.94100 -23.65100 1.000 22.14097 ? 441 ALA   A CA  1 
ATOM   1797 C C   . ALA   A 1 245 ? 26.43300  -19.65200 -24.20100 1.000 28.33340 ? 441 ALA   A C   1 
ATOM   1798 O O   . ALA   A 1 245 ? 27.49200  -19.03200 -24.33200 1.000 26.12322 ? 441 ALA   A O   1 
ATOM   1799 C CB  . ALA   A 1 245 ? 25.17500  -19.07600 -22.14200 1.000 22.55551 ? 441 ALA   A CB  1 
ATOM   1800 N N   . GLN   A 1 246 ? 26.29200  -20.93300 -24.56400 1.000 27.02659 ? 442 GLN   A N   1 
ATOM   1801 C CA  . GLN   A 1 246 ? 27.41000  -21.65500 -25.17100 1.000 22.58535 ? 442 GLN   A CA  1 
ATOM   1802 C C   . GLN   A 1 246 ? 27.76500  -21.07300 -26.54200 1.000 29.18505 ? 442 GLN   A C   1 
ATOM   1803 O O   . GLN   A 1 246 ? 28.94900  -20.98700 -26.90100 1.000 29.30665 ? 442 GLN   A O   1 
ATOM   1804 C CB  . GLN   A 1 246 ? 27.05300  -23.14100 -25.25900 1.000 29.41311 ? 442 GLN   A CB  1 
ATOM   1805 C CG  . GLN   A 1 246 ? 27.17400  -23.82600 -23.92500 1.000 32.61567 ? 442 GLN   A CG  1 
ATOM   1806 C CD  . GLN   A 1 246 ? 26.41100  -25.13500 -23.86100 1.000 37.12312 ? 442 GLN   A CD  1 
ATOM   1807 O OE1 . GLN   A 1 246 ? 25.81700  -25.57200 -24.84500 1.000 42.76623 ? 442 GLN   A OE1 1 
ATOM   1808 N NE2 . GLN   A 1 246 ? 26.41100  -25.76100 -22.68900 1.000 50.20623 ? 442 GLN   A NE2 1 
ATOM   1809 N N   . LEU   A 1 247 ? 26.76300  -20.63200 -27.31300 1.000 26.44364 ? 443 LEU   A N   1 
ATOM   1810 C CA  . LEU   A 1 247 ? 27.02400  -19.94700 -28.57500 1.000 28.22750 ? 443 LEU   A CA  1 
ATOM   1811 C C   . LEU   A 1 247 ? 27.67500  -18.58900 -28.34700 1.000 25.57242 ? 443 LEU   A C   1 
ATOM   1812 O O   . LEU   A 1 247 ? 28.51700  -18.15500 -29.14200 1.000 28.17934 ? 443 LEU   A O   1 
ATOM   1813 C CB  . LEU   A 1 247 ? 25.71700  -19.77500 -29.36500 1.000 30.73856 ? 443 LEU   A CB  1 
ATOM   1814 C CG  . LEU   A 1 247 ? 25.28200  -20.78900 -30.41300 1.000 37.02623 ? 443 LEU   A CG  1 
ATOM   1815 C CD1 . LEU   A 1 247 ? 24.03000  -20.25300 -31.10700 1.000 34.53537 ? 443 LEU   A CD1 1 
ATOM   1816 C CD2 . LEU   A 1 247 ? 26.38400  -21.07300 -31.42400 1.000 43.70623 ? 443 LEU   A CD2 1 
ATOM   1817 N N   . VAL   A 1 248 ? 27.24600  -17.86800 -27.31500 1.000 24.04754 ? 444 VAL   A N   1 
ATOM   1818 C CA  . VAL   A 1 248 ? 27.88900  -16.60500 -26.98300 1.000 24.70982 ? 444 VAL   A CA  1 
ATOM   1819 C C   . VAL   A 1 248 ? 29.38700  -16.82800 -26.79200 1.000 28.61941 ? 444 VAL   A C   1 
ATOM   1820 O O   . VAL   A 1 248 ? 30.21000  -16.08500 -27.33200 1.000 27.83711 ? 444 VAL   A O   1 
ATOM   1821 C CB  . VAL   A 1 248 ? 27.25200  -15.97100 -25.73700 1.000 24.72787 ? 444 VAL   A CB  1 
ATOM   1822 C CG1 . VAL   A 1 248 ? 28.07800  -14.75600 -25.26800 1.000 28.29475 ? 444 VAL   A CG1 1 
ATOM   1823 C CG2 . VAL   A 1 248 ? 25.79500  -15.53800 -26.02600 1.000 26.02857 ? 444 VAL   A CG2 1 
ATOM   1824 N N   . GLN   A 1 249 ? 29.74700  -17.88800 -26.06900 1.000 25.47239 ? 445 GLN   A N   1 
ATOM   1825 C CA  . GLN   A 1 249 ? 31.16500  -18.15200 -25.79000 1.000 27.63368 ? 445 GLN   A CA  1 
ATOM   1826 C C   . GLN   A 1 249 ? 31.91200  -18.55400 -27.05900 1.000 30.83013 ? 445 GLN   A C   1 
ATOM   1827 O O   . GLN   A 1 249 ? 33.07500  -18.15300 -27.25400 1.000 32.26460 ? 445 GLN   A O   1 
ATOM   1828 C CB  . GLN   A 1 249 ? 31.27600  -19.21400 -24.69800 1.000 25.35498 ? 445 GLN   A CB  1 
ATOM   1829 C CG  . GLN   A 1 249 ? 32.74300  -19.65500 -24.38400 1.000 26.76621 ? 445 GLN   A CG  1 
ATOM   1830 C CD  . GLN   A 1 249 ? 33.58500  -18.55500 -23.79500 1.000 29.15487 ? 445 GLN   A CD  1 
ATOM   1831 O OE1 . GLN   A 1 249 ? 33.08400  -17.51600 -23.36600 1.000 32.97400 ? 445 GLN   A OE1 1 
ATOM   1832 N NE2 . GLN   A 1 249 ? 34.91600  -18.80200 -23.73000 1.000 28.15510 ? 445 GLN   A NE2 1 
ATOM   1833 N N   . ILE   A 1 250 ? 31.26200  -19.32200 -27.94600 1.000 30.13423 ? 446 ILE   A N   1 
ATOM   1834 C CA  . ILE   A 1 250 ? 31.86200  -19.67600 -29.23500 1.000 29.66756 ? 446 ILE   A CA  1 
ATOM   1835 C C   . ILE   A 1 250 ? 32.18000  -18.42400 -30.03600 1.000 39.16623 ? 446 ILE   A C   1 
ATOM   1836 O O   . ILE   A 1 250 ? 33.25400  -18.30100 -30.64300 1.000 39.13667 ? 446 ILE   A O   1 
ATOM   1837 C CB  . ILE   A 1 250 ? 30.93900  -20.61900 -30.02800 1.000 35.34311 ? 446 ILE   A CB  1 
ATOM   1838 C CG1 . ILE   A 1 250 ? 30.97700  -22.01900 -29.42800 1.000 34.22845 ? 446 ILE   A CG1 1 
ATOM   1839 C CG2 . ILE   A 1 250 ? 31.33900  -20.63900 -31.50600 1.000 39.33034 ? 446 ILE   A CG2 1 
ATOM   1840 C CD1 . ILE   A 1 250 ? 30.02900  -22.99200 -30.05300 1.000 39.26661 ? 446 ILE   A CD1 1 
ATOM   1841 N N   . ILE   A 1 251 ? 31.26000  -17.47000 -30.04000 1.000 32.94554 ? 447 ILE   A N   1 
ATOM   1842 C CA  . ILE   A 1 251 ? 31.48100  -16.25700 -30.80800 1.000 36.37834 ? 447 ILE   A CA  1 
ATOM   1843 C C   . ILE   A 1 251 ? 32.56800  -15.40400 -30.16700 1.000 39.04164 ? 447 ILE   A C   1 
ATOM   1844 O O   . ILE   A 1 251 ? 33.45900  -14.89400 -30.86200 1.000 39.64854 ? 447 ILE   A O   1 
ATOM   1845 C CB  . ILE   A 1 251 ? 30.15300  -15.49900 -30.96500 1.000 33.12980 ? 447 ILE   A CB  1 
ATOM   1846 C CG1 . ILE   A 1 251 ? 29.31300  -16.20700 -32.03200 1.000 35.56324 ? 447 ILE   A CG1 1 
ATOM   1847 C CG2 . ILE   A 1 251 ? 30.40400  -14.04200 -31.31500 1.000 36.25668 ? 447 ILE   A CG2 1 
ATOM   1848 C CD1 . ILE   A 1 251 ? 27.83800  -15.81000 -32.00900 1.000 33.29975 ? 447 ILE   A CD1 1 
ATOM   1849 N N   . LYS   A 1 252 ? 32.54700  -15.26800 -28.83700 1.000 33.74257 ? 448 LYS   A N   1 
ATOM   1850 C CA  . LYS   A 1 252 ? 33.46200  -14.33000 -28.19200 1.000 39.52877 ? 448 LYS   A CA  1 
ATOM   1851 C C   . LYS   A 1 252 ? 34.91100  -14.77500 -28.35200 1.000 42.40769 ? 448 LYS   A C   1 
ATOM   1852 O O   . LYS   A 1 252 ? 35.81100  -13.93100 -28.43500 1.000 44.67084 ? 448 LYS   A O   1 
ATOM   1853 C CB  . LYS   A 1 252 ? 33.08600  -14.15000 -26.71200 1.000 37.78958 ? 448 LYS   A CB  1 
ATOM   1854 C CG  . LYS   A 1 252 ? 34.20900  -13.69000 -25.74300 1.000 42.08951 ? 448 LYS   A CG  1 
ATOM   1855 C CD  . LYS   A 1 252 ? 33.84800  -13.97300 -24.27700 1.000 50.96623 ? 448 LYS   A CD  1 
ATOM   1856 C CE  . LYS   A 1 252 ? 34.67400  -15.09700 -23.63600 1.000 43.44623 ? 448 LYS   A CE  1 
ATOM   1857 N NZ  . LYS   A 1 252 ? 34.42000  -15.25500 -22.14400 1.000 33.46119 ? 448 LYS   A NZ  1 
ATOM   1858 N N   . LYS   A 1 253 ? 35.15700  -16.07700 -28.46400 1.000 41.79769 ? 449 LYS   A N   1 
ATOM   1859 C CA  . LYS   A 1 253 ? 36.52400  -16.56300 -28.52600 1.000 44.16014 ? 449 LYS   A CA  1 
ATOM   1860 C C   . LYS   A 1 253 ? 36.97000  -16.98700 -29.92400 1.000 45.08623 ? 449 LYS   A C   1 
ATOM   1861 O O   . LYS   A 1 253 ? 38.16700  -17.20800 -30.12400 1.000 45.43374 ? 449 LYS   A O   1 
ATOM   1862 C CB  . LYS   A 1 253 ? 36.72200  -17.69600 -27.49700 1.000 43.88708 ? 449 LYS   A CB  1 
ATOM   1863 C CG  . LYS   A 1 253 ? 36.74300  -19.14300 -27.97800 1.000 48.23623 ? 449 LYS   A CG  1 
ATOM   1864 C CD  . LYS   A 1 253 ? 36.82500  -20.11800 -26.76500 1.000 47.21623 ? 449 LYS   A CD  1 
ATOM   1865 C CE  . LYS   A 1 253 ? 38.09100  -19.91300 -25.85200 1.000 38.43623 ? 449 LYS   A CE  1 
ATOM   1866 N NZ  . LYS   A 1 253 ? 38.35300  -20.98200 -24.77400 1.000 30.28432 ? 449 LYS   A NZ  1 
ATOM   1867 N N   . THR   A 1 254 ? 36.07000  -17.05600 -30.91300 1.000 43.66164 ? 450 THR   A N   1 
ATOM   1868 C CA  . THR   A 1 254 ? 36.46300  -17.42900 -32.26600 1.000 46.07391 ? 450 THR   A CA  1 
ATOM   1869 C C   . THR   A 1 254 ? 36.19900  -16.36200 -33.31700 1.000 48.39651 ? 450 THR   A C   1 
ATOM   1870 O O   . THR   A 1 254 ? 36.62500  -16.54000 -34.46500 1.000 57.16623 ? 450 THR   A O   1 
ATOM   1871 C CB  . THR   A 1 254 ? 35.75600  -18.71600 -32.71400 1.000 45.32247 ? 450 THR   A CB  1 
ATOM   1872 O OG1 . THR   A 1 254 ? 34.35600  -18.45500 -32.88400 1.000 44.96742 ? 450 THR   A OG1 1 
ATOM   1873 C CG2 . THR   A 1 254 ? 35.94600  -19.81400 -31.68200 1.000 45.97344 ? 450 THR   A CG2 1 
ATOM   1874 N N   . GLU   A 1 255 ? 35.51500  -15.27400 -32.98200 1.000 46.11124 ? 451 GLU   A N   1 
ATOM   1875 C CA  . GLU   A 1 255 ? 35.20100  -14.24600 -33.96200 1.000 48.28469 ? 451 GLU   A CA  1 
ATOM   1876 C C   . GLU   A 1 255 ? 36.08500  -13.03100 -33.72300 1.000 52.73338 ? 451 GLU   A C   1 
ATOM   1877 O O   . GLU   A 1 255 ? 36.21200  -12.55600 -32.59000 1.000 56.54623 ? 451 GLU   A O   1 
ATOM   1878 C CB  . GLU   A 1 255 ? 33.72000  -13.87300 -33.90500 1.000 46.33185 ? 451 GLU   A CB  1 
ATOM   1879 C CG  . GLU   A 1 255 ? 32.81400  -14.93200 -34.50900 1.000 40.48541 ? 451 GLU   A CG  1 
ATOM   1880 C CD  . GLU   A 1 255 ? 33.02400  -15.14400 -35.98800 1.000 41.63272 ? 451 GLU   A CD  1 
ATOM   1881 O OE1 . GLU   A 1 255 ? 33.37300  -14.17100 -36.69700 1.000 38.75881 ? 451 GLU   A OE1 1 
ATOM   1882 O OE2 . GLU   A 1 255 ? 32.80400  -16.28200 -36.45300 1.000 39.31005 ? 451 GLU   A OE2 1 
ATOM   1883 N N   . SER   A 1 256 ? 36.69800  -12.53700 -34.80000 1.000 59.11623 ? 452 SER   A N   1 
ATOM   1884 C CA  . SER   A 1 256 ? 37.67000  -11.45700 -34.68200 1.000 62.47623 ? 452 SER   A CA  1 
ATOM   1885 C C   . SER   A 1 256 ? 37.02400  -10.15500 -34.22900 1.000 55.39670 ? 452 SER   A C   1 
ATOM   1886 O O   . SER   A 1 256 ? 37.62800  -9.40400  -33.45500 1.000 57.38564 ? 452 SER   A O   1 
ATOM   1887 C CB  . SER   A 1 256 ? 38.37300  -11.25000 -36.02600 1.000 57.33252 ? 452 SER   A CB  1 
ATOM   1888 O OG  . SER   A 1 256 ? 38.86300  -12.47600 -36.55000 1.000 59.99980 ? 452 SER   A OG  1 
ATOM   1889 N N   . ASP   A 1 257 ? 35.79800  -9.88400  -34.68000 1.000 50.36177 ? 453 ASP   A N   1 
ATOM   1890 C CA  . ASP   A 1 257 ? 35.23600  -8.53900  -34.67700 1.000 50.21980 ? 453 ASP   A CA  1 
ATOM   1891 C C   . ASP   A 1 257 ? 33.92700  -8.43800  -33.90200 1.000 48.81335 ? 453 ASP   A C   1 
ATOM   1892 O O   . ASP   A 1 257 ? 33.21100  -7.43900  -34.03900 1.000 47.01469 ? 453 ASP   A O   1 
ATOM   1893 C CB  . ASP   A 1 257 ? 35.01100  -8.07700  -36.12500 1.000 50.42941 ? 453 ASP   A CB  1 
ATOM   1894 C CG  . ASP   A 1 257 ? 35.09500  -6.57200  -36.28800 1.000 63.01623 ? 453 ASP   A CG  1 
ATOM   1895 O OD1 . ASP   A 1 257 ? 35.25100  -6.11700  -37.44700 1.000 69.95623 ? 453 ASP   A OD1 1 
ATOM   1896 O OD2 . ASP   A 1 257 ? 35.03300  -5.84200  -35.27000 1.000 61.36623 ? 453 ASP   A OD2 1 
ATOM   1897 N N   . ALA   A 1 258 ? 33.58900  -9.43700  -33.09700 1.000 48.16822 ? 454 ALA   A N   1 
ATOM   1898 C CA  . ALA   A 1 258 ? 32.31400  -9.46300  -32.38800 1.000 45.51515 ? 454 ALA   A CA  1 
ATOM   1899 C C   . ALA   A 1 258 ? 32.58000  -9.24600  -30.90000 1.000 43.40398 ? 454 ALA   A C   1 
ATOM   1900 O O   . ALA   A 1 258 ? 32.56800  -10.17900 -30.09600 1.000 45.88315 ? 454 ALA   A O   1 
ATOM   1901 C CB  . ALA   A 1 258 ? 31.57200  -10.78400 -32.66200 1.000 44.90623 ? 454 ALA   A CB  1 
ATOM   1902 N N   . ALA   A 1 259 ? 32.79900  -7.98800  -30.53400 1.000 43.10351 ? 455 ALA   A N   1 
ATOM   1903 C CA  . ALA   A 1 259 ? 32.97800  -7.61800  -29.13800 1.000 40.96136 ? 455 ALA   A CA  1 
ATOM   1904 C C   . ALA   A 1 259 ? 31.63600  -7.57600  -28.40800 1.000 37.05022 ? 455 ALA   A C   1 
ATOM   1905 O O   . ALA   A 1 259 ? 30.64200  -7.06600  -28.93500 1.000 38.38988 ? 455 ALA   A O   1 
ATOM   1906 C CB  . ALA   A 1 259 ? 33.65900  -6.25600  -29.04100 1.000 39.79943 ? 455 ALA   A CB  1 
ATOM   1907 N N   . LEU   A 1 260 ? 31.63300  -8.07200  -27.17400 1.000 36.36054 ? 456 LEU   A N   1 
ATOM   1908 C CA  . LEU   A 1 260 ? 30.43700  -8.06900  -26.34400 1.000 35.65849 ? 456 LEU   A CA  1 
ATOM   1909 C C   . LEU   A 1 260 ? 30.23900  -6.72400  -25.66500 1.000 37.68901 ? 456 LEU   A C   1 
ATOM   1910 O O   . LEU   A 1 260 ? 31.17100  -6.15200  -25.09100 1.000 32.97964 ? 456 LEU   A O   1 
ATOM   1911 C CB  . LEU   A 1 260 ? 30.53500  -9.13300  -25.25600 1.000 37.33519 ? 456 LEU   A CB  1 
ATOM   1912 C CG  . LEU   A 1 260 ? 30.44100  -10.59900 -25.62400 1.000 44.20623 ? 456 LEU   A CG  1 
ATOM   1913 C CD1 . LEU   A 1 260 ? 30.14800  -11.40400 -24.36900 1.000 36.60792 ? 456 LEU   A CD1 1 
ATOM   1914 C CD2 . LEU   A 1 260 ? 29.37100  -10.79000 -26.66900 1.000 41.47623 ? 456 LEU   A CD2 1 
ATOM   1915 N N   . HIS   A 1 261 ? 29.00400  -6.25400  -25.68600 1.000 31.30561 ? 457 HIS   A N   1 
ATOM   1916 C CA  . HIS   A 1 261 ? 28.62600  -5.11700  -24.87300 1.000 32.93031 ? 457 HIS   A CA  1 
ATOM   1917 C C   . HIS   A 1 261 ? 28.87800  -5.44000  -23.40100 1.000 32.56278 ? 457 HIS   A C   1 
ATOM   1918 O O   . HIS   A 1 261 ? 28.58800  -6.55800  -22.94400 1.000 30.25164 ? 457 HIS   A O   1 
ATOM   1919 C CB  . HIS   A 1 261 ? 27.15500  -4.77900  -25.10600 1.000 32.44191 ? 457 HIS   A CB  1 
ATOM   1920 C CG  . HIS   A 1 261 ? 26.70400  -3.50500  -24.45800 1.000 33.09100 ? 457 HIS   A CG  1 
ATOM   1921 N ND1 . HIS   A 1 261 ? 26.59200  -3.35600  -23.09100 1.000 32.51176 ? 457 HIS   A ND1 1 
ATOM   1922 C CD2 . HIS   A 1 261 ? 26.28400  -2.33400  -25.00100 1.000 33.74410 ? 457 HIS   A CD2 1 
ATOM   1923 C CE1 . HIS   A 1 261 ? 26.17000  -2.13200  -22.81700 1.000 35.98751 ? 457 HIS   A CE1 1 
ATOM   1924 N NE2 . HIS   A 1 261 ? 25.96200  -1.49500  -23.96000 1.000 34.96400 ? 457 HIS   A NE2 1 
ATOM   1925 N N   . PRO   A 1 262 ? 29.41300  -4.49600  -22.62900 1.000 33.46996 ? 458 PRO   A N   1 
ATOM   1926 C CA  . PRO   A 1 262 ? 29.80100  -4.81900  -21.24700 1.000 34.57820 ? 458 PRO   A CA  1 
ATOM   1927 C C   . PRO   A 1 262 ? 28.64500  -5.24300  -20.34900 1.000 30.67277 ? 458 PRO   A C   1 
ATOM   1928 O O   . PRO   A 1 262 ? 28.85900  -6.05800  -19.44600 1.000 29.10238 ? 458 PRO   A O   1 
ATOM   1929 C CB  . PRO   A 1 262 ? 30.44900  -3.51800  -20.75000 1.000 36.11855 ? 458 PRO   A CB  1 
ATOM   1930 C CG  . PRO   A 1 262 ? 30.82400  -2.77200  -21.99500 1.000 38.00597 ? 458 PRO   A CG  1 
ATOM   1931 C CD  . PRO   A 1 262 ? 29.82800  -3.14200  -23.03600 1.000 37.24314 ? 458 PRO   A CD  1 
ATOM   1932 N N   . LEU   A 1 263 ? 27.43600  -4.71200  -20.53900 1.000 28.63690 ? 459 LEU   A N   1 
ATOM   1933 C CA  . LEU   A 1 263 ? 26.32400  -5.19000  -19.72400 1.000 31.10887 ? 459 LEU   A CA  1 
ATOM   1934 C C   . LEU   A 1 263 ? 25.99900  -6.64800  -20.04000 1.000 25.70569 ? 459 LEU   A C   1 
ATOM   1935 O O   . LEU   A 1 263 ? 25.73800  -7.44500  -19.12500 1.000 23.51033 ? 459 LEU   A O   1 
ATOM   1936 C CB  . LEU   A 1 263 ? 25.10500  -4.30100  -19.92600 1.000 30.64094 ? 459 LEU   A CB  1 
ATOM   1937 C CG  . LEU   A 1 263 ? 23.79100  -4.76000  -19.29900 1.000 30.26209 ? 459 LEU   A CG  1 
ATOM   1938 C CD1 . LEU   A 1 263 ? 23.83900  -4.72800  -17.77800 1.000 28.60723 ? 459 LEU   A CD1 1 
ATOM   1939 C CD2 . LEU   A 1 263 ? 22.64500  -3.90400  -19.81300 1.000 30.30762 ? 459 LEU   A CD2 1 
ATOM   1940 N N   . LEU   A 1 264 ? 25.99800  -7.01300  -21.31900 1.000 25.44767 ? 460 LEU   A N   1 
ATOM   1941 C CA  . LEU   A 1 264 ? 25.69800  -8.40500  -21.65300 1.000 25.79696 ? 460 LEU   A CA  1 
ATOM   1942 C C   . LEU   A 1 264 ? 26.84300  -9.31200  -21.21600 1.000 26.36110 ? 460 LEU   A C   1 
ATOM   1943 O O   . LEU   A 1 264 ? 26.61600  -10.43500 -20.75200 1.000 26.31290 ? 460 LEU   A O   1 
ATOM   1944 C CB  . LEU   A 1 264 ? 25.40600  -8.55400  -23.15500 1.000 29.00953 ? 460 LEU   A CB  1 
ATOM   1945 C CG  . LEU   A 1 264 ? 24.35900  -7.61800  -23.76500 1.000 25.22106 ? 460 LEU   A CG  1 
ATOM   1946 C CD1 . LEU   A 1 264 ? 24.12900  -7.91300  -25.25200 1.000 27.39164 ? 460 LEU   A CD1 1 
ATOM   1947 C CD2 . LEU   A 1 264 ? 23.03000  -7.69100  -23.00600 1.000 23.51139 ? 460 LEU   A CD2 1 
ATOM   1948 N N   . GLN   A 1 265 ? 28.08100  -8.82000  -21.30000 1.000 25.97108 ? 461 GLN   A N   1 
ATOM   1949 C CA  . GLN   A 1 265 ? 29.19500  -9.58100  -20.74500 1.000 30.60001 ? 461 GLN   A CA  1 
ATOM   1950 C C   . GLN   A 1 265 ? 29.01100  -9.84900  -19.25300 1.000 25.24480 ? 461 GLN   A C   1 
ATOM   1951 O O   . GLN   A 1 265 ? 29.19100  -10.97700 -18.78800 1.000 28.03744 ? 461 GLN   A O   1 
ATOM   1952 C CB  . GLN   A 1 265 ? 30.50500  -8.83700  -21.01900 1.000 29.50996 ? 461 GLN   A CB  1 
ATOM   1953 C CG  . GLN   A 1 265 ? 31.70900  -9.52500  -20.40900 1.000 35.89658 ? 461 GLN   A CG  1 
ATOM   1954 C CD  . GLN   A 1 265 ? 32.08900  -10.76500 -21.18700 1.000 38.32406 ? 461 GLN   A CD  1 
ATOM   1955 O OE1 . GLN   A 1 265 ? 32.96100  -10.72900 -22.05400 1.000 40.88042 ? 461 GLN   A OE1 1 
ATOM   1956 N NE2 . GLN   A 1 265 ? 31.43300  -11.88300 -20.87200 1.000 41.01951 ? 461 GLN   A NE2 1 
ATOM   1957 N N   . GLU   A 1 266 ? 28.59300  -8.83900  -18.49600 1.000 27.82195 ? 462 GLU   A N   1 
ATOM   1958 C CA  . GLU   A 1 266 ? 28.32000  -9.03000  -17.07600 1.000 26.63905 ? 462 GLU   A CA  1 
ATOM   1959 C C   . GLU   A 1 266 ? 27.24000  -10.08200 -16.84200 1.000 28.40198 ? 462 GLU   A C   1 
ATOM   1960 O O   . GLU   A 1 266 ? 27.34800  -10.90600 -15.92700 1.000 27.20628 ? 462 GLU   A O   1 
ATOM   1961 C CB  . GLU   A 1 266 ? 27.90300  -7.69700  -16.45700 1.000 31.88505 ? 462 GLU   A CB  1 
ATOM   1962 C CG  . GLU   A 1 266 ? 27.46000  -7.80700  -15.01900 1.000 32.98503 ? 462 GLU   A CG  1 
ATOM   1963 C CD  . GLU   A 1 266 ? 27.21200  -6.44700  -14.39300 1.000 39.38380 ? 462 GLU   A CD  1 
ATOM   1964 O OE1 . GLU   A 1 266 ? 28.06700  -5.54300  -14.56500 1.000 44.72623 ? 462 GLU   A OE1 1 
ATOM   1965 O OE2 . GLU   A 1 266 ? 26.18200  -6.29200  -13.71100 1.000 42.12218 ? 462 GLU   A OE2 1 
ATOM   1966 N N   . ILE   A 1 267 ? 26.17600  -10.05800 -17.65000 1.000 24.40357 ? 463 ILE   A N   1 
ATOM   1967 C CA  . ILE   A 1 267 ? 25.08800  -11.00800 -17.45100 1.000 26.11603 ? 463 ILE   A CA  1 
ATOM   1968 C C   . ILE   A 1 267 ? 25.55200  -12.43800 -17.71700 1.000 22.19345 ? 463 ILE   A C   1 
ATOM   1969 O O   . ILE   A 1 267 ? 25.24500  -13.35900 -16.94200 1.000 24.99330 ? 463 ILE   A O   1 
ATOM   1970 C CB  . ILE   A 1 267 ? 23.88800  -10.61400 -18.34300 1.000 22.70469 ? 463 ILE   A CB  1 
ATOM   1971 C CG1 . ILE   A 1 267 ? 23.23200  -9.33000  -17.82900 1.000 27.84945 ? 463 ILE   A CG1 1 
ATOM   1972 C CG2 . ILE   A 1 267 ? 22.84400  -11.74400 -18.40600 1.000 24.76246 ? 463 ILE   A CG2 1 
ATOM   1973 C CD1 . ILE   A 1 267 ? 22.24400  -8.71600  -18.81500 1.000 26.51421 ? 463 ILE   A CD1 1 
ATOM   1974 N N   . TYR   A 1 268 ? 26.30200  -12.65100 -18.79500 1.000 24.26038 ? 464 TYR   A N   1 
ATOM   1975 C CA  . TYR   A 1 268 ? 26.73300  -13.99300 -19.17400 1.000 26.13758 ? 464 TYR   A CA  1 
ATOM   1976 C C   . TYR   A 1 268 ? 27.88300  -14.51300 -18.30800 1.000 29.08352 ? 464 TYR   A C   1 
ATOM   1977 O O   . TYR   A 1 268 ? 28.00600  -15.72200 -18.15500 1.000 30.09345 ? 464 TYR   A O   1 
ATOM   1978 C CB  . TYR   A 1 268 ? 27.14000  -14.01600 -20.65300 1.000 25.27300 ? 464 TYR   A CB  1 
ATOM   1979 C CG  . TYR   A 1 268 ? 25.95200  -14.05400 -21.59500 1.000 28.80300 ? 464 TYR   A CG  1 
ATOM   1980 C CD1 . TYR   A 1 268 ? 25.06700  -15.12000 -21.56500 1.000 27.16209 ? 464 TYR   A CD1 1 
ATOM   1981 C CD2 . TYR   A 1 268 ? 25.72100  -13.01800 -22.48800 1.000 28.01423 ? 464 TYR   A CD2 1 
ATOM   1982 C CE1 . TYR   A 1 268 ? 23.95800  -15.15200 -22.43200 1.000 27.69736 ? 464 TYR   A CE1 1 
ATOM   1983 C CE2 . TYR   A 1 268 ? 24.63100  -13.03400 -23.34400 1.000 27.60888 ? 464 TYR   A CE2 1 
ATOM   1984 C CZ  . TYR   A 1 268 ? 23.75800  -14.10500 -23.30600 1.000 28.37195 ? 464 TYR   A CZ  1 
ATOM   1985 O OH  . TYR   A 1 268 ? 22.68900  -14.10900 -24.18300 1.000 28.04051 ? 464 TYR   A OH  1 
ATOM   1986 N N   . ARG   A 1 269 ? 28.67200  -13.62500 -17.70900 1.000 28.46948 ? 465 ARG   A N   1 
ATOM   1987 C CA  . ARG   A 1 269 ? 29.79900  -14.02700 -16.85800 1.000 33.41326 ? 465 ARG   A CA  1 
ATOM   1988 C C   . ARG   A 1 269 ? 29.34400  -14.88900 -15.68400 1.000 36.53962 ? 465 ARG   A C   1 
ATOM   1989 O O   . ARG   A 1 269 ? 28.59400  -14.42000 -14.82500 1.000 33.58601 ? 465 ARG   A O   1 
ATOM   1990 C CB  . ARG   A 1 269 ? 30.49600  -12.78300 -16.32100 1.000 33.64866 ? 465 ARG   A CB  1 
ATOM   1991 C CG  . ARG   A 1 269 ? 31.84400  -13.06300 -15.64200 1.000 41.01420 ? 465 ARG   A CG  1 
ATOM   1992 C CD  . ARG   A 1 269 ? 32.91100  -12.11400 -16.13700 1.000 43.89996 ? 465 ARG   A CD  1 
ATOM   1993 N NE  . ARG   A 1 269 ? 33.23400  -12.39900 -17.52700 1.000 56.79623 ? 465 ARG   A NE  1 
ATOM   1994 C CZ  . ARG   A 1 269 ? 34.36900  -12.94500 -17.94200 1.000 47.72623 ? 465 ARG   A CZ  1 
ATOM   1995 N NH1 . ARG   A 1 269 ? 34.53900  -13.29000 -19.20400 1.000 40.85571 ? 465 ARG   A NH1 1 
ATOM   1996 N NH2 . ARG   A 1 269 ? 35.34600  -13.16000 -17.06400 1.000 46.18623 ? 465 ARG   A NH2 1 
ATOM   1997 N N   . ASP   A 1 270 ? 29.83900  -16.13100 -15.60900 1.000 32.19915 ? 466 ASP   A N   1 
ATOM   1998 C CA  . ASP   A 1 270 ? 29.53000  -17.04400 -14.50500 1.000 39.76056 ? 466 ASP   A CA  1 
ATOM   1999 C C   . ASP   A 1 270 ? 28.05900  -17.40700 -14.46200 1.000 45.04623 ? 466 ASP   A C   1 
ATOM   2000 O O   . ASP   A 1 270 ? 27.53800  -17.74700 -13.39200 1.000 45.29336 ? 466 ASP   A O   1 
ATOM   2001 C CB  . ASP   A 1 270 ? 29.94300  -16.48100 -13.13600 1.000 38.96792 ? 466 ASP   A CB  1 
ATOM   2002 C CG  . ASP   A 1 270 ? 31.35000  -15.94600 -13.12200 1.000 41.76933 ? 466 ASP   A CG  1 
ATOM   2003 O OD1 . ASP   A 1 270 ? 32.25900  -16.75000 -13.36500 1.000 40.39365 ? 466 ASP   A OD1 1 
ATOM   2004 O OD2 . ASP   A 1 270 ? 31.55600  -14.74400 -12.85100 1.000 45.79623 ? 466 ASP   A OD2 1 
ATOM   2005 N N   . MET   A 1 271 ? 27.37500  -17.30200 -15.60200 1.000 38.23736 ? 467 MET   A N   1 
ATOM   2006 C CA  . MET   A 1 271 ? 26.00100  -17.77000 -15.71000 1.000 48.46623 ? 467 MET   A CA  1 
ATOM   2007 C C   . MET   A 1 271 ? 25.92000  -19.27000 -15.51100 1.000 52.50623 ? 467 MET   A C   1 
ATOM   2008 O O   . MET   A 1 271 ? 25.49800  -19.75300 -14.45400 1.000 51.05682 ? 467 MET   A O   1 
ATOM   2009 C CB  . MET   A 1 271 ? 25.40800  -17.44200 -17.08000 1.000 44.64112 ? 467 MET   A CB  1 
ATOM   2010 C CG  . MET   A 1 271 ? 23.95000  -17.81900 -17.17500 1.000 51.56623 ? 467 MET   A CG  1 
ATOM   2011 S SD  . MET   A 1 271 ? 22.89800  -16.87600 -18.26900 1.000 42.52841 ? 467 MET   A SD  1 
ATOM   2012 C CE  . MET   A 1 271 ? 22.96200  -15.26400 -17.52700 1.000 34.04264 ? 467 MET   A CE  1 
ATOM   2013 N N   . TYR   A 1 272 ? 26.31500  -19.99900 -16.54700 1.000 50.79721 ? 468 TYR   A N   1 
ATOM   2014 C CA  . TYR   A 1 272 ? 26.16700  -21.43800 -16.61000 1.000 53.22837 ? 468 TYR   A CA  1 
ATOM   2015 C C   . TYR   A 1 272 ? 27.49700  -22.06000 -17.02700 1.000 56.04663 ? 468 TYR   A C   1 
ATOM   2016 O O   . TYR   A 1 272 ? 27.88600  -21.99400 -18.19400 1.000 66.21623 ? 468 TYR   A O   1 
ATOM   2017 C CB  . TYR   A 1 272 ? 25.05200  -21.80000 -17.59700 1.000 51.35448 ? 468 TYR   A CB  1 
ATOM   2018 C CG  . TYR   A 1 272 ? 23.65300  -21.53300 -17.07200 1.000 48.94083 ? 468 TYR   A CG  1 
ATOM   2019 C CD1 . TYR   A 1 272 ? 23.26000  -21.98800 -15.81300 1.000 47.88295 ? 468 TYR   A CD1 1 
ATOM   2020 C CD2 . TYR   A 1 272 ? 22.73100  -20.80700 -17.82400 1.000 45.87623 ? 468 TYR   A CD2 1 
ATOM   2021 C CE1 . TYR   A 1 272 ? 21.98200  -21.74400 -15.32400 1.000 50.06623 ? 468 TYR   A CE1 1 
ATOM   2022 C CE2 . TYR   A 1 272 ? 21.44700  -20.54600 -17.33900 1.000 41.52482 ? 468 TYR   A CE2 1 
ATOM   2023 C CZ  . TYR   A 1 272 ? 21.08200  -21.02200 -16.09100 1.000 49.71623 ? 468 TYR   A CZ  1 
ATOM   2024 O OH  . TYR   A 1 272 ? 19.81300  -20.77800 -15.60700 1.000 43.57576 ? 468 TYR   A OH  1 
ATOM   2025 O OXT . TYR   A 1 272 ? 28.21400  -22.62800 -16.20300 1.000 59.71673 ? 468 TYR   A OXT 1 
ATOM   2026 N N   . PRO   B 2 7   ? 30.62800  -1.31600  -8.40800  1.000 61.50481 ? 141 PRO   B N   1 
ATOM   2027 C CA  . PRO   B 2 7   ? 29.28900  -1.87900  -8.55800  1.000 62.33623 ? 141 PRO   B CA  1 
ATOM   2028 C C   . PRO   B 2 7   ? 29.04500  -2.17800  -10.00500 1.000 54.67545 ? 141 PRO   B C   1 
ATOM   2029 O O   . PRO   B 2 7   ? 29.40300  -1.40500  -10.85700 1.000 54.32496 ? 141 PRO   B O   1 
ATOM   2030 C CB  . PRO   B 2 7   ? 28.37500  -0.73100  -8.13600  1.000 61.38062 ? 141 PRO   B CB  1 
ATOM   2031 C CG  . PRO   B 2 7   ? 29.27500  0.46200   -7.97700  1.000 62.28760 ? 141 PRO   B CG  1 
ATOM   2032 C CD  . PRO   B 2 7   ? 30.57500  0.12200   -8.61900  1.000 63.03101 ? 141 PRO   B CD  1 
ATOM   2033 N N   . SER   B 2 8   ? 28.38400  -3.28400  -10.26000 1.000 50.06716 ? 142 SER   B N   1 
ATOM   2034 C CA  . SER   B 2 8   ? 28.10700  -3.70200  -11.59800 1.000 45.99854 ? 142 SER   B CA  1 
ATOM   2035 C C   . SER   B 2 8   ? 27.12300  -2.86000  -12.34700 1.000 41.36937 ? 142 SER   B C   1 
ATOM   2036 O O   . SER   B 2 8   ? 26.38900  -2.08300  -11.80100 1.000 40.03087 ? 142 SER   B O   1 
ATOM   2037 C CB  . SER   B 2 8   ? 27.57500  -5.10200  -11.56100 1.000 43.06707 ? 142 SER   B CB  1 
ATOM   2038 O OG  . SER   B 2 8   ? 26.30800  -5.11100  -10.98700 1.000 42.81903 ? 142 SER   B OG  1 
ATOM   2039 N N   . LEU   B 2 9   ? 27.13700  -3.05700  -13.64100 1.000 41.37361 ? 143 LEU   B N   1 
ATOM   2040 C CA  . LEU   B 2 9   ? 26.23600  -2.39300  -14.52700 1.000 37.48371 ? 143 LEU   B CA  1 
ATOM   2041 C C   . LEU   B 2 9   ? 24.80400  -2.76200  -14.18500 1.000 40.02605 ? 143 LEU   B C   1 
ATOM   2042 O O   . LEU   B 2 9   ? 23.94300  -1.92800  -14.22300 1.000 36.89649 ? 143 LEU   B O   1 
ATOM   2043 C CB  . LEU   B 2 9   ? 26.56600  -2.79200  -15.93600 1.000 38.90803 ? 143 LEU   B CB  1 
ATOM   2044 C CG  . LEU   B 2 9   ? 27.91900  -2.28000  -16.31300 1.000 43.57936 ? 143 LEU   B CG  1 
ATOM   2045 C CD1 . LEU   B 2 9   ? 28.45200  -2.97600  -17.53800 1.000 38.49959 ? 143 LEU   B CD1 1 
ATOM   2046 C CD2 . LEU   B 2 9   ? 27.73500  -0.83000  -16.60700 1.000 46.15623 ? 143 LEU   B CD2 1 
ATOM   2047 N N   . LEU   B 2 10  ? 24.56800  -4.02900  -13.87300 1.000 36.86206 ? 144 LEU   B N   1 
ATOM   2048 C CA  . LEU   B 2 10  ? 23.22600  -4.43000  -13.46800 1.000 36.48251 ? 144 LEU   B CA  1 
ATOM   2049 C C   . LEU   B 2 10  ? 22.80900  -3.74000  -12.18300 1.000 38.49124 ? 144 LEU   B C   1 
ATOM   2050 O O   . LEU   B 2 10  ? 21.66600  -3.29000  -12.05000 1.000 34.43480 ? 144 LEU   B O   1 
ATOM   2051 C CB  . LEU   B 2 10  ? 23.17700  -5.94600  -13.28100 1.000 37.73134 ? 144 LEU   B CB  1 
ATOM   2052 C CG  . LEU   B 2 10  ? 22.02200  -6.79700  -13.78700 1.000 41.97623 ? 144 LEU   B CG  1 
ATOM   2053 C CD1 . LEU   B 2 10  ? 21.63000  -6.44400  -15.20800 1.000 38.94623 ? 144 LEU   B CD1 1 
ATOM   2054 C CD2 . LEU   B 2 10  ? 22.42300  -8.25900  -13.66300 1.000 35.55165 ? 144 LEU   B CD2 1 
ATOM   2055 N N   . LYS   B 2 11  ? 23.71600  -3.67100  -11.20700 1.000 37.11844 ? 145 LYS   B N   1 
ATOM   2056 C CA  . LYS   B 2 11  ? 23.37900  -3.02400  -9.95400  1.000 36.48179 ? 145 LYS   B CA  1 
ATOM   2057 C C   . LYS   B 2 11  ? 23.09000  -1.54700  -10.17400 1.000 38.26711 ? 145 LYS   B C   1 
ATOM   2058 O O   . LYS   B 2 11  ? 22.22100  -0.97100  -9.50500  1.000 36.02908 ? 145 LYS   B O   1 
ATOM   2059 C CB  . LYS   B 2 11  ? 24.53400  -3.22100  -8.96200  1.000 38.81897 ? 145 LYS   B CB  1 
ATOM   2060 C CG  . LYS   B 2 11  ? 24.12600  -3.12500  -7.53000  1.000 42.59500 ? 145 LYS   B CG  1 
ATOM   2061 C CD  . LYS   B 2 11  ? 25.11400  -3.90600  -6.67100  1.000 44.99472 ? 145 LYS   B CD  1 
ATOM   2062 C CE  . LYS   B 2 11  ? 24.69400  -3.94200  -5.23300  1.000 46.15679 ? 145 LYS   B CE  1 
ATOM   2063 N NZ  . LYS   B 2 11  ? 25.68200  -4.71100  -4.43800  1.000 50.40623 ? 145 LYS   B NZ  1 
ATOM   2064 N N   . LYS   B 2 12  ? 23.81800  -0.92800  -11.10600 1.000 39.66714 ? 146 LYS   B N   1 
ATOM   2065 C CA  . LYS   B 2 12  ? 23.56400  0.45800   -11.48100 1.000 38.80097 ? 146 LYS   B CA  1 
ATOM   2066 C C   . LYS   B 2 12  ? 22.16900  0.63000   -12.08100 1.000 43.73623 ? 146 LYS   B C   1 
ATOM   2067 O O   . LYS   B 2 12  ? 21.47600  1.60600   -11.76700 1.000 40.42431 ? 146 LYS   B O   1 
ATOM   2068 C CB  . LYS   B 2 12  ? 24.65700  0.93400   -12.44300 1.000 41.75625 ? 146 LYS   B CB  1 
ATOM   2069 C CG  . LYS   B 2 12  ? 24.73600  2.44400   -12.58700 1.000 55.51623 ? 146 LYS   B CG  1 
ATOM   2070 C CD  . LYS   B 2 12  ? 26.03800  2.88400   -13.24000 1.000 59.07454 ? 146 LYS   B CD  1 
ATOM   2071 C CE  . LYS   B 2 12  ? 27.20100  1.99400   -12.80900 1.000 60.76623 ? 146 LYS   B CE  1 
ATOM   2072 N NZ  . LYS   B 2 12  ? 28.38200  2.12400   -13.71000 1.000 73.26974 ? 146 LYS   B NZ  1 
ATOM   2073 N N   . LEU   B 2 13  ? 21.72000  -0.31700  -12.91600 1.000 35.84652 ? 147 LEU   B N   1 
ATOM   2074 C CA  . LEU   B 2 13  ? 20.35400  -0.25000  -13.43400 1.000 38.67823 ? 147 LEU   B CA  1 
ATOM   2075 C C   . LEU   B 2 13  ? 19.32900  -0.35700  -12.31200 1.000 36.47026 ? 147 LEU   B C   1 
ATOM   2076 O O   . LEU   B 2 13  ? 18.30300  0.33200   -12.33200 1.000 39.81509 ? 147 LEU   B O   1 
ATOM   2077 C CB  . LEU   B 2 13  ? 20.11500  -1.35700  -14.46800 1.000 36.79842 ? 147 LEU   B CB  1 
ATOM   2078 C CG  . LEU   B 2 13  ? 20.74300  -1.17800  -15.85100 1.000 38.13575 ? 147 LEU   B CG  1 
ATOM   2079 C CD1 . LEU   B 2 13  ? 20.55500  -2.43300  -16.70200 1.000 35.05892 ? 147 LEU   B CD1 1 
ATOM   2080 C CD2 . LEU   B 2 13  ? 20.19400  0.04700   -16.55800 1.000 39.26081 ? 147 LEU   B CD2 1 
ATOM   2081 N N   . LEU   B 2 14  ? 19.57300  -1.22300  -11.32300 1.000 31.88234 ? 148 LEU   B N   1 
ATOM   2082 C CA  . LEU   B 2 14  ? 18.57600  -1.39700  -10.27300 1.000 37.29038 ? 148 LEU   B CA  1 
ATOM   2083 C C   . LEU   B 2 14  ? 18.50900  -0.18400  -9.35900  1.000 42.04039 ? 148 LEU   B C   1 
ATOM   2084 O O   . LEU   B 2 14  ? 17.45100  0.09600   -8.78100  1.000 44.80602 ? 148 LEU   B O   1 
ATOM   2085 C CB  . LEU   B 2 14  ? 18.87300  -2.64700  -9.45100  1.000 35.55540 ? 148 LEU   B CB  1 
ATOM   2086 C CG  . LEU   B 2 14  ? 18.42800  -3.93600  -10.11900 1.000 34.93964 ? 148 LEU   B CG  1 
ATOM   2087 C CD1 . LEU   B 2 14  ? 19.21500  -5.11800  -9.59900  1.000 36.15622 ? 148 LEU   B CD1 1 
ATOM   2088 C CD2 . LEU   B 2 14  ? 16.92400  -4.11800  -9.90400  1.000 30.01418 ? 148 LEU   B CD2 1 
ATOM   2089 N N   . LEU   B 2 15  ? 19.61700  0.54900   -9.22500  1.000 43.27283 ? 149 LEU   B N   1 
ATOM   2090 C CA  . LEU   B 2 15  ? 19.67000  1.67600   -8.30800  1.000 46.32101 ? 149 LEU   B CA  1 
ATOM   2091 C C   . LEU   B 2 15  ? 19.14600  2.96400   -8.92600  1.000 48.67125 ? 149 LEU   B C   1 
ATOM   2092 O O   . LEU   B 2 15  ? 18.83600  3.90400   -8.18700  1.000 55.17623 ? 149 LEU   B O   1 
ATOM   2093 C CB  . LEU   B 2 15  ? 21.10700  1.88100   -7.81700  1.000 49.26476 ? 149 LEU   B CB  1 
ATOM   2094 C CG  . LEU   B 2 15  ? 21.43700  1.17600   -6.50000  1.000 52.93258 ? 149 LEU   B CG  1 
ATOM   2095 C CD1 . LEU   B 2 15  ? 22.91300  0.82000   -6.44500  1.000 50.66584 ? 149 LEU   B CD1 1 
ATOM   2096 C CD2 . LEU   B 2 15  ? 21.03700  2.03100   -5.30700  1.000 55.46646 ? 149 LEU   B CD2 1 
ATOM   2097 N N   . ALA   B 2 16  ? 19.02500  3.02600   -10.24800 1.000 48.11491 ? 150 ALA   B N   1 
ATOM   2098 C CA  . ALA   B 2 16  ? 18.54200  4.23100   -10.92100 1.000 50.56672 ? 150 ALA   B CA  1 
ATOM   2099 C C   . ALA   B 2 16  ? 17.11200  4.58100   -10.50700 1.000 55.58577 ? 150 ALA   B C   1 
ATOM   2100 O O   . ALA   B 2 16  ? 16.79600  5.75300   -10.26900 1.000 58.50158 ? 150 ALA   B O   1 
ATOM   2101 C CB  . ALA   B 2 16  ? 18.62800  4.06400   -12.43100 1.000 47.52024 ? 150 ALA   B CB  1 
HETATM 2102 C C01 . A1LZY C 3 .   ? 19.38500  -11.76500 -30.09800 1.000 25.00372 ? 500 A1LZY A C01 1 
HETATM 2103 C C02 . A1LZY C 3 .   ? 19.82600  -11.73300 -28.77700 1.000 28.29897 ? 500 A1LZY A C02 1 
HETATM 2104 C C03 . A1LZY C 3 .   ? 21.15400  -12.04400 -28.50900 1.000 23.65398 ? 500 A1LZY A C03 1 
HETATM 2105 C C04 . A1LZY C 3 .   ? 21.97100  -12.37000 -29.59800 1.000 23.64485 ? 500 A1LZY A C04 1 
HETATM 2106 C C05 . A1LZY C 3 .   ? 21.43800  -12.37800 -30.89100 1.000 21.07886 ? 500 A1LZY A C05 1 
HETATM 2107 C C06 . A1LZY C 3 .   ? 23.35600  -12.72800 -29.79600 1.000 22.47691 ? 500 A1LZY A C06 1 
HETATM 2108 C C07 . A1LZY C 3 .   ? 21.66700  -11.94900 -27.08300 1.000 21.24627 ? 500 A1LZY A C07 1 
HETATM 2109 C C08 . A1LZY C 3 .   ? 24.47800  -12.90100 -28.77500 1.000 24.43348 ? 500 A1LZY A C08 1 
HETATM 2110 C C09 . A1LZY C 3 .   ? 24.96800  -11.49600 -28.43100 1.000 26.01152 ? 500 A1LZY A C09 1 
HETATM 2111 C C10 . A1LZY C 3 .   ? 25.55500  -13.81900 -29.37400 1.000 22.86987 ? 500 A1LZY A C10 1 
HETATM 2112 C C11 . A1LZY C 3 .   ? 25.99300  -11.51200 -27.30700 1.000 28.37398 ? 500 A1LZY A C11 1 
HETATM 2113 C C12 . A1LZY C 3 .   ? 25.09200  -15.28300 -29.49700 1.000 24.09911 ? 500 A1LZY A C12 1 
HETATM 2114 C C13 . A1LZY C 3 .   ? 21.27200  -13.30900 -33.86800 1.000 23.97733 ? 500 A1LZY A C13 1 
HETATM 2115 C C14 . A1LZY C 3 .   ? 21.32300  -13.35600 -35.24000 1.000 25.72027 ? 500 A1LZY A C14 1 
HETATM 2116 C C15 . A1LZY C 3 .   ? 22.44000  -12.90200 -35.92500 1.000 23.18496 ? 500 A1LZY A C15 1 
HETATM 2117 C C16 . A1LZY C 3 .   ? 23.52800  -12.39500 -35.23200 1.000 25.67376 ? 500 A1LZY A C16 1 
HETATM 2118 C C17 . A1LZY C 3 .   ? 23.48800  -12.35800 -33.86200 1.000 23.64064 ? 500 A1LZY A C17 1 
HETATM 2119 C C18 . A1LZY C 3 .   ? 22.36100  -12.83000 -33.16900 1.000 24.88565 ? 500 A1LZY A C18 1 
HETATM 2120 C C26 . A1LZY C 3 .   ? 17.67000  -11.33100 -31.61800 1.000 28.67532 ? 500 A1LZY A C26 1 
HETATM 2121 C C27 . A1LZY C 3 .   ? 17.22300  -9.89400  -31.79600 1.000 31.62544 ? 500 A1LZY A C27 1 
HETATM 2122 C C28 . A1LZY C 3 .   ? 17.41000  -9.33800  -33.19700 1.000 28.29174 ? 500 A1LZY A C28 1 
HETATM 2123 C C29 . A1LZY C 3 .   ? 17.47900  -9.99600  -34.44900 1.000 26.92030 ? 500 A1LZY A C29 1 
HETATM 2124 C C31 . A1LZY C 3 .   ? 17.71700  -7.90000  -34.78900 1.000 26.93692 ? 500 A1LZY A C31 1 
HETATM 2125 C C33 . A1LZY C 3 .   ? 17.91300  -6.64400  -35.61100 1.000 31.71562 ? 500 A1LZY A C33 1 
HETATM 2126 C C34 . A1LZY C 3 .   ? 18.26700  -6.77000  -36.94100 1.000 32.25675 ? 500 A1LZY A C34 1 
HETATM 2127 C C35 . A1LZY C 3 .   ? 18.44700  -5.63600  -37.72400 1.000 43.60623 ? 500 A1LZY A C35 1 
HETATM 2128 C C36 . A1LZY C 3 .   ? 18.26100  -4.38000  -37.15500 1.000 33.22918 ? 500 A1LZY A C36 1 
HETATM 2129 C C37 . A1LZY C 3 .   ? 17.90100  -4.27000  -35.82600 1.000 31.66438 ? 500 A1LZY A C37 1 
HETATM 2130 C C38 . A1LZY C 3 .   ? 17.72300  -5.39400  -35.04600 1.000 32.66325 ? 500 A1LZY A C38 1 
HETATM 2131 C C39 . A1LZY C 3 .   ? 17.39300  -11.48100 -34.82900 1.000 27.77374 ? 500 A1LZY A C39 1 
HETATM 2132 F F19 . A1LZY C 3 .   ? 22.42000  -12.97400 -37.28300 1.000 29.83400 ? 500 A1LZY A F19 1 
HETATM 2133 N N20 . A1LZY C 3 .   ? 20.14100  -12.08300 -31.12600 1.000 23.78683 ? 500 A1LZY A N20 1 
HETATM 2134 N N21 . A1LZY C 3 .   ? 23.53400  -12.91600 -31.06600 1.000 20.75626 ? 500 A1LZY A N21 1 
HETATM 2135 N N22 . A1LZY C 3 .   ? 22.40200  -12.73000 -31.74100 1.000 22.68592 ? 500 A1LZY A N22 1 
HETATM 2136 N N32 . A1LZY C 3 .   ? 17.56100  -8.00700  -33.48700 1.000 26.94754 ? 500 A1LZY A N32 1 
HETATM 2137 O O23 . A1LZY C 3 .   ? 21.49100  -10.85600 -26.46800 1.000 27.07837 ? 500 A1LZY A O23 1 
HETATM 2138 O O24 . A1LZY C 3 .   ? 22.27400  -12.89200 -26.53700 1.000 26.02269 ? 500 A1LZY A O24 1 
HETATM 2139 O O25 . A1LZY C 3 .   ? 18.03100  -11.47200 -30.29700 1.000 24.79738 ? 500 A1LZY A O25 1 
HETATM 2140 O O30 . A1LZY C 3 .   ? 17.67200  -9.08400  -35.35200 1.000 32.00513 ? 500 A1LZY A O30 1 
HETATM 2141 O O   . HOH   D 4 .   ? 32.67800  -18.95400 -12.85400 1.000 42.98572 ? 601 HOH   A O   1 
HETATM 2142 O O   . HOH   D 4 .   ? 8.48900   3.10500   -15.52000 1.000 44.81442 ? 602 HOH   A O   1 
HETATM 2143 O O   . HOH   D 4 .   ? 18.48000  -19.04300 -17.21000 1.000 33.84611 ? 603 HOH   A O   1 
HETATM 2144 O O   . HOH   D 4 .   ? 3.07400   -15.00100 -34.15800 1.000 39.25623 ? 604 HOH   A O   1 
HETATM 2145 O O   . HOH   D 4 .   ? 16.95300  0.80900   -14.76500 1.000 42.73190 ? 605 HOH   A O   1 
HETATM 2146 O O   . HOH   D 4 .   ? 24.28500  -15.39000 -8.03800  1.000 47.51623 ? 606 HOH   A O   1 
HETATM 2147 O O   . HOH   D 4 .   ? 33.25300  -19.00800 -35.07000 1.000 47.38651 ? 607 HOH   A O   1 
HETATM 2148 O O   . HOH   D 4 .   ? 1.28600   -17.39000 -1.24400  1.000 44.96834 ? 608 HOH   A O   1 
HETATM 2149 O O   . HOH   D 4 .   ? -5.41300  -28.89300 -21.81800 1.000 38.90679 ? 609 HOH   A O   1 
HETATM 2150 O O   . HOH   D 4 .   ? 33.06600  -4.54800  -25.62400 1.000 45.53581 ? 610 HOH   A O   1 
HETATM 2151 O O   . HOH   D 4 .   ? 27.35500  -11.18400 -12.66900 1.000 43.39510 ? 611 HOH   A O   1 
HETATM 2152 O O   . HOH   D 4 .   ? 15.51400  -15.36300 2.92500   1.000 45.35409 ? 612 HOH   A O   1 
HETATM 2153 O O   . HOH   D 4 .   ? 11.87500  -20.70100 -42.31000 1.000 41.87623 ? 613 HOH   A O   1 
HETATM 2154 O O   . HOH   D 4 .   ? -6.26800  -22.91900 -17.89000 1.000 31.43255 ? 614 HOH   A O   1 
HETATM 2155 O O   . HOH   D 4 .   ? 22.55900  -12.99700 -4.61500  1.000 37.82000 ? 615 HOH   A O   1 
HETATM 2156 O O   . HOH   D 4 .   ? 34.62700  -11.54200 -36.27900 1.000 45.90892 ? 616 HOH   A O   1 
HETATM 2157 O O   . HOH   D 4 .   ? 1.86100   -1.62300  -11.47900 1.000 29.95800 ? 617 HOH   A O   1 
HETATM 2158 O O   . HOH   D 4 .   ? -13.63100 -17.64500 -17.56400 1.000 35.78857 ? 618 HOH   A O   1 
HETATM 2159 O O   . HOH   D 4 .   ? 22.46000  -14.14500 -47.23000 1.000 42.52623 ? 619 HOH   A O   1 
HETATM 2160 O O   . HOH   D 4 .   ? 18.93400  -20.64700 -13.14600 1.000 36.91449 ? 620 HOH   A O   1 
HETATM 2161 O O   . HOH   D 4 .   ? -9.63100  -18.41000 -11.34700 1.000 40.41850 ? 621 HOH   A O   1 
HETATM 2162 O O   . HOH   D 4 .   ? 4.63100   -27.09000 -22.53000 1.000 26.42375 ? 622 HOH   A O   1 
HETATM 2163 O O   . HOH   D 4 .   ? 13.97100  -14.40000 -46.90400 1.000 36.17067 ? 623 HOH   A O   1 
HETATM 2164 O O   . HOH   D 4 .   ? 3.86900   -1.83700  -8.94000  1.000 41.04596 ? 624 HOH   A O   1 
HETATM 2165 O O   . HOH   D 4 .   ? 7.37900   -27.81200 -24.27400 1.000 34.54841 ? 625 HOH   A O   1 
HETATM 2166 O O   . HOH   D 4 .   ? 15.50600  -26.84400 -17.81300 1.000 33.12977 ? 626 HOH   A O   1 
HETATM 2167 O O   . HOH   D 4 .   ? 16.24400  -18.55900 -38.54500 1.000 26.24787 ? 627 HOH   A O   1 
HETATM 2168 O O   . HOH   D 4 .   ? 3.25900   -15.58500 -27.23000 1.000 21.73268 ? 628 HOH   A O   1 
HETATM 2169 O O   . HOH   D 4 .   ? 8.87100   -3.89700  -6.04500  1.000 31.21867 ? 629 HOH   A O   1 
HETATM 2170 O O   . HOH   D 4 .   ? 9.22500   -12.47400 0.60500   1.000 39.67321 ? 630 HOH   A O   1 
HETATM 2171 O O   . HOH   D 4 .   ? 22.04700  -23.60200 -32.52000 1.000 39.81594 ? 631 HOH   A O   1 
HETATM 2172 O O   . HOH   D 4 .   ? -7.08200  -13.84800 -24.68600 1.000 36.00012 ? 632 HOH   A O   1 
HETATM 2173 O O   . HOH   D 4 .   ? 5.24700   -14.04500 -25.96100 1.000 21.93899 ? 633 HOH   A O   1 
HETATM 2174 O O   . HOH   D 4 .   ? 1.64100   -21.17100 -5.60100  1.000 37.53856 ? 634 HOH   A O   1 
HETATM 2175 O O   . HOH   D 4 .   ? 27.37700  -22.92600 -34.56100 1.000 44.67694 ? 635 HOH   A O   1 
HETATM 2176 O O   . HOH   D 4 .   ? 8.24700   -21.34000 -4.08700  1.000 41.68131 ? 636 HOH   A O   1 
HETATM 2177 O O   . HOH   D 4 .   ? -7.23000  -3.72900  -3.76600  1.000 48.91527 ? 637 HOH   A O   1 
HETATM 2178 O O   . HOH   D 4 .   ? 15.37500  -1.88000  -6.35500  1.000 40.74814 ? 638 HOH   A O   1 
HETATM 2179 O O   . HOH   D 4 .   ? 13.19200  -23.21700 -40.79300 1.000 40.50812 ? 639 HOH   A O   1 
HETATM 2180 O O   . HOH   D 4 .   ? -0.31000  -16.55500 -30.12900 1.000 25.65645 ? 640 HOH   A O   1 
HETATM 2181 O O   . HOH   D 4 .   ? -2.59200  -9.24000  -25.77700 1.000 29.72984 ? 641 HOH   A O   1 
HETATM 2182 O O   . HOH   D 4 .   ? -4.43400  -22.78400 -13.63500 1.000 34.43048 ? 642 HOH   A O   1 
HETATM 2183 O O   . HOH   D 4 .   ? 5.48900   -9.93000  -24.99900 1.000 25.68401 ? 643 HOH   A O   1 
HETATM 2184 O O   . HOH   D 4 .   ? 19.44100  -24.07900 -28.50900 1.000 31.28018 ? 644 HOH   A O   1 
HETATM 2185 O O   . HOH   D 4 .   ? 15.34100  -15.06700 -11.93200 1.000 24.78674 ? 645 HOH   A O   1 
HETATM 2186 O O   . HOH   D 4 .   ? 4.76300   0.81100   -23.15300 1.000 38.04848 ? 646 HOH   A O   1 
HETATM 2187 O O   . HOH   D 4 .   ? 13.77400  -24.64200 -29.30200 1.000 33.23834 ? 647 HOH   A O   1 
HETATM 2188 O O   . HOH   D 4 .   ? 9.77200   0.39400   -11.99900 1.000 33.43506 ? 648 HOH   A O   1 
HETATM 2189 O O   . HOH   D 4 .   ? -3.11400  -22.97500 -31.31500 1.000 39.67550 ? 649 HOH   A O   1 
HETATM 2190 O O   . HOH   D 4 .   ? 1.94300   -2.91300  -40.81200 1.000 49.11623 ? 650 HOH   A O   1 
HETATM 2191 O O   . HOH   D 4 .   ? 31.24100  -6.30700  -18.11300 1.000 35.87319 ? 651 HOH   A O   1 
HETATM 2192 O O   . HOH   D 4 .   ? 17.98800  -19.61200 -46.14300 1.000 36.07697 ? 652 HOH   A O   1 
HETATM 2193 O O   . HOH   D 4 .   ? 20.39400  -16.77800 -36.48600 1.000 24.65276 ? 653 HOH   A O   1 
HETATM 2194 O O   . HOH   D 4 .   ? 9.69600   -4.39400  -25.48900 1.000 33.96301 ? 654 HOH   A O   1 
HETATM 2195 O O   . HOH   D 4 .   ? 30.89200  -22.64800 -25.87500 1.000 35.49439 ? 655 HOH   A O   1 
HETATM 2196 O O   . HOH   D 4 .   ? -3.06500  -13.31800 -27.98900 1.000 35.84555 ? 656 HOH   A O   1 
HETATM 2197 O O   . HOH   D 4 .   ? 18.74600  5.87000   -38.82800 1.000 38.80233 ? 657 HOH   A O   1 
HETATM 2198 O O   . HOH   D 4 .   ? 2.60600   -20.67100 -33.81200 1.000 31.38067 ? 658 HOH   A O   1 
HETATM 2199 O O   . HOH   D 4 .   ? 11.97000  -5.19800  -48.56400 1.000 37.35866 ? 659 HOH   A O   1 
HETATM 2200 O O   . HOH   D 4 .   ? 9.27500   -9.09600  -0.92400  1.000 38.75259 ? 660 HOH   A O   1 
HETATM 2201 O O   . HOH   D 4 .   ? 5.70400   -0.42300  -38.17100 1.000 41.19006 ? 661 HOH   A O   1 
HETATM 2202 O O   . HOH   D 4 .   ? 10.17500  1.43900   -23.19300 1.000 40.23623 ? 662 HOH   A O   1 
HETATM 2203 O O   . HOH   D 4 .   ? 0.23500   0.73600   -17.31500 1.000 35.39830 ? 663 HOH   A O   1 
HETATM 2204 O O   . HOH   D 4 .   ? -4.18300  -22.51900 -24.71600 1.000 27.05798 ? 664 HOH   A O   1 
HETATM 2205 O O   . HOH   D 4 .   ? 24.35900  -24.16700 -28.23500 1.000 35.90058 ? 665 HOH   A O   1 
HETATM 2206 O O   . HOH   D 4 .   ? 32.09400  -14.47600 -19.83100 1.000 43.42778 ? 666 HOH   A O   1 
HETATM 2207 O O   . HOH   D 4 .   ? 4.56400   -9.67400  -3.49300  1.000 45.93623 ? 667 HOH   A O   1 
HETATM 2208 O O   . HOH   D 4 .   ? 2.33600   -25.69200 -28.48200 1.000 35.31148 ? 668 HOH   A O   1 
HETATM 2209 O O   . HOH   D 4 .   ? 8.55300   -25.14800 -33.52300 1.000 37.36760 ? 669 HOH   A O   1 
HETATM 2210 O O   . HOH   D 4 .   ? 10.97800  0.69400   -19.38900 1.000 36.67672 ? 670 HOH   A O   1 
HETATM 2211 O O   . HOH   D 4 .   ? 12.29100  -10.01400 -25.85400 1.000 30.75838 ? 671 HOH   A O   1 
HETATM 2212 O O   . HOH   D 4 .   ? 18.82800  -18.64500 -37.54800 1.000 28.71724 ? 672 HOH   A O   1 
HETATM 2213 O O   . HOH   D 4 .   ? 3.28700   -18.07000 -37.53900 1.000 35.23182 ? 673 HOH   A O   1 
HETATM 2214 O O   . HOH   D 4 .   ? 13.26900  -21.00000 -15.11900 1.000 34.86534 ? 674 HOH   A O   1 
HETATM 2215 O O   . HOH   D 4 .   ? 29.26300  -10.78700 -13.88200 1.000 40.15039 ? 675 HOH   A O   1 
HETATM 2216 O O   . HOH   D 4 .   ? 12.46900  -6.99200  -31.70400 1.000 35.55920 ? 676 HOH   A O   1 
HETATM 2217 O O   . HOH   D 4 .   ? 13.07000  -6.53100  -52.05300 1.000 50.81606 ? 677 HOH   A O   1 
HETATM 2218 O O   . HOH   D 4 .   ? -8.92600  -28.53700 -21.50100 1.000 37.79387 ? 678 HOH   A O   1 
HETATM 2219 O O   . HOH   D 4 .   ? 16.24200  -10.68600 -0.37600  1.000 43.31355 ? 679 HOH   A O   1 
HETATM 2220 O O   . HOH   D 4 .   ? 3.84900   -3.13400  -23.17400 1.000 33.14783 ? 680 HOH   A O   1 
HETATM 2221 O O   . HOH   D 4 .   ? -7.18800  -10.94300 -19.14400 1.000 36.67290 ? 681 HOH   A O   1 
HETATM 2222 O O   . HOH   D 4 .   ? 1.26300   -17.52600 -26.68600 1.000 18.58670 ? 682 HOH   A O   1 
HETATM 2223 O O   . HOH   D 4 .   ? 19.49500  -14.48000 -18.18700 1.000 24.82569 ? 683 HOH   A O   1 
HETATM 2224 O O   . HOH   D 4 .   ? 16.97800  -9.57200  -27.83500 1.000 34.84943 ? 684 HOH   A O   1 
HETATM 2225 O O   . HOH   D 4 .   ? 11.42300  -16.65500 -43.82400 1.000 26.74803 ? 685 HOH   A O   1 
HETATM 2226 O O   . HOH   D 4 .   ? 7.38600   1.07000   -13.58200 1.000 36.51361 ? 686 HOH   A O   1 
HETATM 2227 O O   . HOH   D 4 .   ? 14.83900  -5.19500  -32.43400 1.000 30.95807 ? 687 HOH   A O   1 
HETATM 2228 O O   . HOH   D 4 .   ? 17.48700  -11.95500 -53.26700 1.000 41.50078 ? 688 HOH   A O   1 
HETATM 2229 O O   . HOH   D 4 .   ? 5.92800   -5.12100  -44.81700 1.000 49.68623 ? 689 HOH   A O   1 
HETATM 2230 O O   . HOH   D 4 .   ? -4.14700  -8.83400  -22.40200 1.000 30.06369 ? 690 HOH   A O   1 
HETATM 2231 O O   . HOH   D 4 .   ? -2.36700  -5.63700  -24.14000 1.000 37.66645 ? 691 HOH   A O   1 
HETATM 2232 O O   . HOH   D 4 .   ? -6.52700  -12.32200 -12.87000 1.000 39.97638 ? 692 HOH   A O   1 
HETATM 2233 O O   . HOH   D 4 .   ? 7.87900   -23.77600 -26.80900 1.000 28.41244 ? 693 HOH   A O   1 
HETATM 2234 O O   . HOH   D 4 .   ? 18.51400  -14.06800 -48.93000 1.000 40.97159 ? 694 HOH   A O   1 
HETATM 2235 O O   . HOH   D 4 .   ? 14.99900  -13.31400 -50.76000 1.000 42.06090 ? 695 HOH   A O   1 
HETATM 2236 O O   . HOH   D 4 .   ? 16.49000  -18.72300 3.23400   1.000 42.57796 ? 696 HOH   A O   1 
HETATM 2237 O O   . HOH   D 4 .   ? -5.46300  -14.89900 -26.78200 1.000 37.57345 ? 697 HOH   A O   1 
HETATM 2238 O O   . HOH   D 4 .   ? 11.85900  -2.02600  1.78200   1.000 45.69235 ? 698 HOH   A O   1 
HETATM 2239 O O   . HOH   D 4 .   ? 14.63200  -25.89000 -24.78400 1.000 28.60285 ? 699 HOH   A O   1 
HETATM 2240 O O   . HOH   D 4 .   ? 3.77300   -26.69200 -26.97800 1.000 34.97786 ? 700 HOH   A O   1 
HETATM 2241 O O   . HOH   D 4 .   ? 19.27700  -21.42500 -27.75100 1.000 23.97641 ? 701 HOH   A O   1 
HETATM 2242 O O   . HOH   D 4 .   ? 10.42900  -4.58700  -32.80600 1.000 28.50422 ? 702 HOH   A O   1 
HETATM 2243 O O   . HOH   D 4 .   ? 10.80800  -3.56800  -30.08200 1.000 31.52382 ? 703 HOH   A O   1 
HETATM 2244 O O   . HOH   D 4 .   ? 9.56400   -25.17100 -14.24200 1.000 35.92117 ? 704 HOH   A O   1 
HETATM 2245 O O   . HOH   D 4 .   ? 9.63300   -25.43800 -25.95300 1.000 35.66880 ? 705 HOH   A O   1 
HETATM 2246 O O   . HOH   D 4 .   ? 7.33300   -3.51500  -3.45200  1.000 38.29881 ? 706 HOH   A O   1 
HETATM 2247 O O   . HOH   D 4 .   ? 19.85500  -4.23400  -0.01500  1.000 44.82950 ? 707 HOH   A O   1 
HETATM 2248 O O   . HOH   D 4 .   ? 27.47500  -6.00400  -46.57400 1.000 38.44837 ? 708 HOH   A O   1 
HETATM 2249 O O   . HOH   D 4 .   ? 23.99900  -20.93300 -44.05200 1.000 40.83774 ? 709 HOH   A O   1 
HETATM 2250 O O   . HOH   D 4 .   ? 8.40000   -0.05500  -45.61200 1.000 46.48623 ? 710 HOH   A O   1 
HETATM 2251 O O   . HOH   D 4 .   ? 9.20900   -24.10500 -36.31900 1.000 39.38377 ? 711 HOH   A O   1 
HETATM 2252 O O   . HOH   D 4 .   ? 15.34000  0.50200   -23.28400 1.000 44.86623 ? 712 HOH   A O   1 
HETATM 2253 O O   . HOH   D 4 .   ? 22.56400  5.80900   -36.22700 1.000 43.31751 ? 713 HOH   A O   1 
HETATM 2254 O O   . HOH   D 4 .   ? 33.95500  -9.24400  -25.76800 1.000 43.79235 ? 714 HOH   A O   1 
HETATM 2255 O O   . HOH   D 4 .   ? 3.35200   -0.70900  -39.49300 1.000 47.33925 ? 715 HOH   A O   1 
HETATM 2256 O O   . HOH   D 4 .   ? 9.72400   -3.86500  -47.31000 1.000 34.65687 ? 716 HOH   A O   1 
HETATM 2257 O O   . HOH   D 4 .   ? 14.65300  -10.54900 1.83600   1.000 45.54602 ? 717 HOH   A O   1 
HETATM 2258 O O   . HOH   D 4 .   ? -8.11000  -11.27700 -21.74000 1.000 38.71273 ? 718 HOH   A O   1 
HETATM 2259 O O   . HOH   D 4 .   ? 12.43000  -17.47400 -28.37900 1.000 26.60920 ? 719 HOH   A O   1 
HETATM 2260 O O   . HOH   D 4 .   ? 4.43800   -11.76900 -41.90800 1.000 39.32338 ? 720 HOH   A O   1 
HETATM 2261 O O   . HOH   D 4 .   ? 25.38100  -7.79100  -7.08700  1.000 42.48579 ? 721 HOH   A O   1 
HETATM 2262 O O   . HOH   D 4 .   ? -0.99700  -27.21400 -26.66800 1.000 46.06995 ? 722 HOH   A O   1 
HETATM 2263 O O   . HOH   D 4 .   ? 20.30900  3.85600   -25.76800 1.000 53.95623 ? 723 HOH   A O   1 
HETATM 2264 O O   . HOH   D 4 .   ? 13.44100  -3.14900  -30.84100 1.000 29.39069 ? 724 HOH   A O   1 
HETATM 2265 O O   . HOH   D 4 .   ? 28.87900  -21.23700 -43.04100 1.000 41.10937 ? 725 HOH   A O   1 
HETATM 2266 O O   . HOH   D 4 .   ? 20.96100  -9.22400  -52.12000 1.000 33.87189 ? 726 HOH   A O   1 
HETATM 2267 O O   . HOH   D 4 .   ? 29.22900  -9.07400  -45.67200 1.000 39.50013 ? 727 HOH   A O   1 
HETATM 2268 O O   . HOH   D 4 .   ? 16.43300  -26.45700 -26.34600 1.000 37.40533 ? 728 HOH   A O   1 
HETATM 2269 O O   . HOH   D 4 .   ? 14.93000  -4.32500  -52.71700 1.000 49.54623 ? 729 HOH   A O   1 
HETATM 2270 O O   . HOH   D 4 .   ? 15.28600  -1.50300  -3.79200  1.000 42.21392 ? 730 HOH   A O   1 
HETATM 2271 O O   . HOH   D 4 .   ? 1.09600   -15.30500 -32.38700 1.000 39.15422 ? 731 HOH   A O   1 
HETATM 2272 O O   . HOH   D 4 .   ? 17.65400  -26.38700 -13.68100 1.000 48.83203 ? 732 HOH   A O   1 
HETATM 2273 O O   . HOH   D 4 .   ? 33.87500  -8.23500  -39.62900 1.000 43.11560 ? 733 HOH   A O   1 
HETATM 2274 O O   . HOH   D 4 .   ? 24.92500  1.38100   -24.06300 1.000 56.61860 ? 734 HOH   A O   1 
HETATM 2275 O O   . HOH   D 4 .   ? 21.21100  -22.62300 -41.38800 1.000 48.07623 ? 735 HOH   A O   1 
HETATM 2276 O O   . HOH   D 4 .   ? 24.66600  -10.36800 -7.02000  1.000 40.15496 ? 736 HOH   A O   1 
HETATM 2277 O O   . HOH   D 4 .   ? 26.62000  -8.49800  -11.61400 1.000 47.63961 ? 737 HOH   A O   1 
HETATM 2278 O O   . HOH   D 4 .   ? 3.43200   -17.87400 -34.38200 1.000 29.88400 ? 738 HOH   A O   1 
HETATM 2279 O O   . HOH   D 4 .   ? 7.33400   -22.96500 -38.31400 1.000 42.88236 ? 739 HOH   A O   1 
HETATM 2280 O O   . HOH   D 4 .   ? -4.44500  -23.82400 -16.14500 1.000 34.20665 ? 740 HOH   A O   1 
HETATM 2281 O O   . HOH   D 4 .   ? -3.81400  -23.96700 -27.20700 1.000 41.14151 ? 741 HOH   A O   1 
HETATM 2282 O O   . HOH   D 4 .   ? 1.63300   -12.88100 -38.16200 1.000 37.38913 ? 742 HOH   A O   1 
HETATM 2283 O O   . HOH   D 4 .   ? 14.70100  -8.48200  -27.28100 1.000 32.91699 ? 743 HOH   A O   1 
HETATM 2284 O O   . HOH   D 4 .   ? 21.66100  -1.83400  -50.74200 1.000 38.63381 ? 744 HOH   A O   1 
HETATM 2285 O O   . HOH   D 4 .   ? 18.32200  -26.61800 -17.85500 1.000 40.52623 ? 745 HOH   A O   1 
HETATM 2286 O O   . HOH   D 4 .   ? -0.57600  -10.92300 -37.01800 1.000 43.43342 ? 746 HOH   A O   1 
HETATM 2287 O O   . HOH   D 4 .   ? 12.54700  -9.42100  1.76300   1.000 42.46147 ? 747 HOH   A O   1 
HETATM 2288 O O   . HOH   D 4 .   ? 29.63300  -23.36200 -20.57800 1.000 46.98231 ? 748 HOH   A O   1 
HETATM 2289 O O   . HOH   D 4 .   ? 21.41300  -11.92200 -50.86400 1.000 38.45855 ? 749 HOH   A O   1 
HETATM 2290 O O   . HOH   D 4 .   ? 29.470    -19.116   -18.196   1.000 45.34940 ? 750 HOH   A O   1 
HETATM 2291 O O   . HOH   D 4 .   ? 3.89300   -12.21700 -4.26600  1.000 38.02096 ? 751 HOH   A O   1 
HETATM 2292 O O   . HOH   D 4 .   ? -2.76100  -10.04500 -15.37700 1.000 35.31924 ? 752 HOH   A O   1 
HETATM 2293 O O   . HOH   D 4 .   ? 26.80700  -17.38500 -46.31800 1.000 47.37623 ? 753 HOH   A O   1 
HETATM 2294 O O   . HOH   D 4 .   ? 5.03800   1.58600   -12.19500 1.000 43.86927 ? 754 HOH   A O   1 
HETATM 2295 O O   . HOH   D 4 .   ? 28.78600  -21.19700 -21.38000 1.000 43.74087 ? 755 HOH   A O   1 
HETATM 2296 O O   . HOH   D 4 .   ? 14.07300  -28.42700 -23.66500 1.000 45.43623 ? 756 HOH   A O   1 
HETATM 2297 O O   . HOH   D 4 .   ? 20.69800  -13.49100 -48.38700 1.000 42.08623 ? 757 HOH   A O   1 
HETATM 2298 O O   . HOH   D 4 .   ? 10.00200  -19.06900 -43.58400 1.000 43.81623 ? 758 HOH   A O   1 
HETATM 2299 O O   . HOH   D 4 .   ? 11.14600  -5.20300  -27.76700 1.000 45.57623 ? 759 HOH   A O   1 
HETATM 2300 O O   . HOH   D 4 .   ? 6.21600   1.23800   -40.14200 1.000 49.02623 ? 760 HOH   A O   1 
HETATM 2301 O O   . HOH   D 4 .   ? 32.10000  -9.03300  -16.99900 1.000 41.09997 ? 761 HOH   A O   1 
HETATM 2302 O O   . HOH   D 4 .   ? 10.31500  -7.28600  -49.53400 1.000 45.20623 ? 762 HOH   A O   1 
HETATM 2303 O O   . HOH   D 4 .   ? -1.64200  -14.09500 -31.93500 1.000 49.38623 ? 763 HOH   A O   1 
HETATM 2304 O O   . HOH   D 4 .   ? 3.14200   0.28300   -13.13600 1.000 37.02131 ? 764 HOH   A O   1 
HETATM 2305 O O   . HOH   D 4 .   ? 16.97000  -16.10600 -47.96600 1.000 43.95623 ? 765 HOH   A O   1 
HETATM 2306 O O   . HOH   D 4 .   ? -4.81200  -8.76500  -15.12900 1.000 36.97935 ? 766 HOH   A O   1 
HETATM 2307 O O   . HOH   D 4 .   ? 18.26600  -26.48400 -30.13000 1.000 48.12623 ? 767 HOH   A O   1 
HETATM 2308 O O   . HOH   D 4 .   ? -14.223   -22.480   -23.320   1.000 35.28346 ? 768 HOH   A O   1 
HETATM 2309 O O   . HOH   D 4 .   ? 2.57300   -27.28800 -24.49200 1.000 35.35417 ? 769 HOH   A O   1 
HETATM 2310 O O   . HOH   D 4 .   ? 5.228     -20.729   4.501     1.000 44.20590 ? 770 HOH   A O   1 
HETATM 2311 O O   . HOH   D 4 .   ? 14.61200  -26.52300 -14.92800 1.000 44.90623 ? 771 HOH   A O   1 
HETATM 2312 O O   . HOH   D 4 .   ? -2.45400  -10.81200 -28.31300 1.000 37.67629 ? 772 HOH   A O   1 
HETATM 2313 O O   . HOH   D 4 .   ? 10.72000  -10.45000 0.13600   1.000 39.86975 ? 773 HOH   A O   1 
HETATM 2314 O O   . HOH   D 4 .   ? 1.13700   2.09100   -14.27400 1.000 41.09098 ? 774 HOH   A O   1 
HETATM 2315 O O   . HOH   D 4 .   ? 0.87400   -0.51200  -38.71600 1.000 53.64623 ? 775 HOH   A O   1 
HETATM 2316 O O   . HOH   D 4 .   ? 22.79400  0.07400   -20.03600 1.000 47.45204 ? 776 HOH   A O   1 
HETATM 2317 O O   . HOH   D 4 .   ? -3.59100  -9.88900  -30.45400 1.000 41.40383 ? 777 HOH   A O   1 
HETATM 2318 O O   . HOH   D 4 .   ? 10.96800  -16.04500 -46.48200 1.000 43.21400 ? 778 HOH   A O   1 
HETATM 2319 O O   . HOH   D 4 .   ? 25.16900  -23.08700 -42.71900 1.000 47.03591 ? 779 HOH   A O   1 
HETATM 2320 O O   . HOH   D 4 .   ? 12.82900  -25.00400 -26.79000 1.000 35.03954 ? 780 HOH   A O   1 
HETATM 2321 O O   . HOH   D 4 .   ? -5.16500  -8.59000  -25.12300 1.000 42.05786 ? 781 HOH   A O   1 
HETATM 2322 O O   . HOH   D 4 .   ? 21.98500  -24.16600 -30.02900 1.000 41.07399 ? 782 HOH   A O   1 
HETATM 2323 O O   . HOH   D 4 .   ? -2.77900  -2.77400  -24.82400 1.000 42.87561 ? 783 HOH   A O   1 
HETATM 2324 O O   . HOH   D 4 .   ? 5.50600   0.88900   -9.45200  1.000 45.09343 ? 784 HOH   A O   1 
HETATM 2325 O O   . HOH   D 4 .   ? 31.52000  -9.10300  -14.67700 1.000 41.59271 ? 785 HOH   A O   1 
HETATM 2326 O O   . HOH   D 4 .   ? 3.08000   -20.98600 -36.77000 1.000 38.62148 ? 786 HOH   A O   1 
HETATM 2327 O O   . HOH   D 4 .   ? 13.636    -19.822   5.544     1.000 47.34241 ? 787 HOH   A O   1 
HETATM 2328 O O   . HOH   D 4 .   ? 22.35800  2.13500   -18.59200 1.000 52.15447 ? 788 HOH   A O   1 
HETATM 2329 O O   . HOH   D 4 .   ? 12.72000  -3.40900  -50.68500 1.000 43.99074 ? 789 HOH   A O   1 
HETATM 2330 O O   . HOH   D 4 .   ? 4.80700   -23.05400 -37.33900 1.000 46.56345 ? 790 HOH   A O   1 
HETATM 2331 O O   . HOH   E 4 .   ? 31.04600  -3.57800  -8.50900  1.000 61.71302 ? 201 HOH   B O   1 
HETATM 2332 O O   . HOH   E 4 .   ? 24.21800  0.13800   -16.14600 1.000 43.10649 ? 202 HOH   B O   1 
HETATM 2333 O O   . HOH   E 4 .   ? 13.20600  0.23200   -6.57100  1.000 46.47964 ? 203 HOH   B O   1 
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