data_8YT6
# 
_entry.id   8YT6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YT6         pdb_00008yt6 10.2210/pdb8yt6/pdb 
WWPDB D_1300046331 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YT6 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yo@phs.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Takuya 
_pdbx_contact_author.name_last          Yoshida 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3491-9344 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachibana, K.' 1  ? 
'Morie, T.'     2  ? 
'Fukuda, S.'    3  ? 
'Yuzuriha, T.'  4  ? 
'Ishimoto, K.'  5  ? 
'Nunomura, K.'  6  ? 
'Lin, B.'       7  ? 
'Miyachi, H.'   8  ? 
'Oki, H.'       9  ? 
'Kawahara, K.'  10 ? 
'Meguro, K.'    11 ? 
'Nakagawa, S.'  12 ? 
'Tsujikawa, K.' 13 ? 
'Akai, S.'      14 ? 
'Doi, T.'       15 ? 
'Yoshida, T.'   16 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachibana, K.' 1  ? 
primary 'Morie, T.'     2  ? 
primary 'Fukuda, S.'    3  ? 
primary 'Yuzuriha, T.'  4  ? 
primary 'Ishimoto, K.'  5  ? 
primary 'Nunomura, K.'  6  ? 
primary 'Lin, B.'       7  ? 
primary 'Miyachi, H.'   8  ? 
primary 'Oki, H.'       9  ? 
primary 'Kawahara, K.'  10 ? 
primary 'Meguro, K.'    11 ? 
primary 'Nakagawa, S.'  12 ? 
primary 'Tsujikawa, K.' 13 ? 
primary 'Akai, S.'      14 ? 
primary 'Doi, T.'       15 ? 
primary 'Yoshida, T.'   16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peroxisome proliferator-activated receptor alpha'                                             30684.814 1   ? ? 
? ? 
2 polymer     syn 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha'                         2405.782  1   ? ? 
? ? 
3 non-polymer syn '6-(2-ethoxyethyl)-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 399.459   1   ? ? 
? ? 
4 water       nat water                                                                                          18.015    105 ? ? 
? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'PPAR-alpha,Nuclear receptor subfamily 1 group C member 1'                            
2 'PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
A ? 
2 'polypeptide(L)' no no PQEAEEPSLLKKLLLAPANTQL PQEAEEPSLLKKLLLAPANTQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '6-(2-ethoxyethyl)-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' A1LZX 
4 water                                                                                          HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   GLN n 
1 4   THR n 
1 5   ALA n 
1 6   ASP n 
1 7   LEU n 
1 8   LYS n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  LYS n 
1 13  ARG n 
1 14  ILE n 
1 15  TYR n 
1 16  GLU n 
1 17  ALA n 
1 18  TYR n 
1 19  LEU n 
1 20  LYS n 
1 21  ASN n 
1 22  PHE n 
1 23  ASN n 
1 24  MET n 
1 25  ASN n 
1 26  LYS n 
1 27  VAL n 
1 28  LYS n 
1 29  ALA n 
1 30  ARG n 
1 31  VAL n 
1 32  ILE n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  LYS n 
1 37  ALA n 
1 38  SER n 
1 39  ASN n 
1 40  ASN n 
1 41  PRO n 
1 42  PRO n 
1 43  PHE n 
1 44  VAL n 
1 45  ILE n 
1 46  HIS n 
1 47  ASP n 
1 48  MET n 
1 49  GLU n 
1 50  THR n 
1 51  LEU n 
1 52  CYS n 
1 53  MET n 
1 54  ALA n 
1 55  GLU n 
1 56  LYS n 
1 57  THR n 
1 58  LEU n 
1 59  VAL n 
1 60  ALA n 
1 61  LYS n 
1 62  LEU n 
1 63  VAL n 
1 64  ALA n 
1 65  ASN n 
1 66  GLY n 
1 67  ILE n 
1 68  GLN n 
1 69  ASN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLU n 
1 74  VAL n 
1 75  ARG n 
1 76  ILE n 
1 77  PHE n 
1 78  HIS n 
1 79  CYS n 
1 80  CYS n 
1 81  GLN n 
1 82  CYS n 
1 83  THR n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  THR n 
1 88  VAL n 
1 89  THR n 
1 90  GLU n 
1 91  LEU n 
1 92  THR n 
1 93  GLU n 
1 94  PHE n 
1 95  ALA n 
1 96  LYS n 
1 97  ALA n 
1 98  ILE n 
1 99  PRO n 
1 100 GLY n 
1 101 PHE n 
1 102 ALA n 
1 103 ASN n 
1 104 LEU n 
1 105 ASP n 
1 106 LEU n 
1 107 ASN n 
1 108 ASP n 
1 109 GLN n 
1 110 VAL n 
1 111 THR n 
1 112 LEU n 
1 113 LEU n 
1 114 LYS n 
1 115 TYR n 
1 116 GLY n 
1 117 VAL n 
1 118 TYR n 
1 119 GLU n 
1 120 ALA n 
1 121 ILE n 
1 122 PHE n 
1 123 ALA n 
1 124 MET n 
1 125 LEU n 
1 126 SER n 
1 127 SER n 
1 128 VAL n 
1 129 MET n 
1 130 ASN n 
1 131 LYS n 
1 132 ASP n 
1 133 GLY n 
1 134 MET n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 TYR n 
1 139 GLY n 
1 140 ASN n 
1 141 GLY n 
1 142 PHE n 
1 143 ILE n 
1 144 THR n 
1 145 ARG n 
1 146 GLU n 
1 147 PHE n 
1 148 LEU n 
1 149 LYS n 
1 150 SER n 
1 151 LEU n 
1 152 ARG n 
1 153 LYS n 
1 154 PRO n 
1 155 PHE n 
1 156 CYS n 
1 157 ASP n 
1 158 ILE n 
1 159 MET n 
1 160 GLU n 
1 161 PRO n 
1 162 LYS n 
1 163 PHE n 
1 164 ASP n 
1 165 PHE n 
1 166 ALA n 
1 167 MET n 
1 168 LYS n 
1 169 PHE n 
1 170 ASN n 
1 171 ALA n 
1 172 LEU n 
1 173 GLU n 
1 174 LEU n 
1 175 ASP n 
1 176 ASP n 
1 177 SER n 
1 178 ASP n 
1 179 ILE n 
1 180 SER n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 ALA n 
1 185 ALA n 
1 186 ILE n 
1 187 ILE n 
1 188 CYS n 
1 189 CYS n 
1 190 GLY n 
1 191 ASP n 
1 192 ARG n 
1 193 PRO n 
1 194 GLY n 
1 195 LEU n 
1 196 LEU n 
1 197 ASN n 
1 198 VAL n 
1 199 GLY n 
1 200 HIS n 
1 201 ILE n 
1 202 GLU n 
1 203 LYS n 
1 204 MET n 
1 205 GLN n 
1 206 GLU n 
1 207 GLY n 
1 208 ILE n 
1 209 VAL n 
1 210 HIS n 
1 211 VAL n 
1 212 LEU n 
1 213 ARG n 
1 214 LEU n 
1 215 HIS n 
1 216 LEU n 
1 217 GLN n 
1 218 SER n 
1 219 ASN n 
1 220 HIS n 
1 221 PRO n 
1 222 ASP n 
1 223 ASP n 
1 224 ILE n 
1 225 PHE n 
1 226 LEU n 
1 227 PHE n 
1 228 PRO n 
1 229 LYS n 
1 230 LEU n 
1 231 LEU n 
1 232 GLN n 
1 233 LYS n 
1 234 MET n 
1 235 ALA n 
1 236 ASP n 
1 237 LEU n 
1 238 ARG n 
1 239 GLN n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 GLU n 
1 244 HIS n 
1 245 ALA n 
1 246 GLN n 
1 247 LEU n 
1 248 VAL n 
1 249 GLN n 
1 250 ILE n 
1 251 ILE n 
1 252 LYS n 
1 253 LYS n 
1 254 THR n 
1 255 GLU n 
1 256 SER n 
1 257 ASP n 
1 258 ALA n 
1 259 ALA n 
1 260 LEU n 
1 261 HIS n 
1 262 PRO n 
1 263 LEU n 
1 264 LEU n 
1 265 GLN n 
1 266 GLU n 
1 267 ILE n 
1 268 TYR n 
1 269 ARG n 
1 270 ASP n 
1 271 MET n 
1 272 TYR n 
2 1   PRO n 
2 2   GLN n 
2 3   GLU n 
2 4   ALA n 
2 5   GLU n 
2 6   GLU n 
2 7   PRO n 
2 8   SER n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  LYS n 
2 13  LEU n 
2 14  LEU n 
2 15  LEU n 
2 16  ALA n 
2 17  PRO n 
2 18  ALA n 
2 19  ASN n 
2 20  THR n 
2 21  GLN n 
2 22  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   272 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PPARA, NR1C1, PPAR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       22 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LZX non-polymer         . '6-(2-ethoxyethyl)-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' ? 
'C22 H26 F N3 O3' 399.459 
ALA   'L-peptide linking' y ALANINE                                                                                        ? 
'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE                                                                                       ? 
'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                                     ? 
'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                                ? 
'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE                                                                                       ? 
'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                                                      ? 
'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                                ? 
'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE                                                                                        ? 
'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE                                                                                      ? 
'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER                                                                                          ? 
'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                                                     ? 
'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE                                                                                        ? 
'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE                                                                                         ? 
'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE                                                                                     ? 
'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                                                                  ? 
'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE                                                                                        ? 
'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE                                                                                         ? 
'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE                                                                                      ? 
'C4 H9 N O3'      119.119 
TYR   'L-peptide linking' y TYROSINE                                                                                       ? 
'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE                                                                                         ? 
'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   197 ?   ?   ?   A . n 
A 1 2   GLY 2   198 ?   ?   ?   A . n 
A 1 3   GLN 3   199 ?   ?   ?   A . n 
A 1 4   THR 4   200 ?   ?   ?   A . n 
A 1 5   ALA 5   201 ?   ?   ?   A . n 
A 1 6   ASP 6   202 202 ASP ASP A . n 
A 1 7   LEU 7   203 203 LEU LEU A . n 
A 1 8   LYS 8   204 204 LYS LYS A . n 
A 1 9   SER 9   205 205 SER SER A . n 
A 1 10  LEU 10  206 206 LEU LEU A . n 
A 1 11  ALA 11  207 207 ALA ALA A . n 
A 1 12  LYS 12  208 208 LYS LYS A . n 
A 1 13  ARG 13  209 209 ARG ARG A . n 
A 1 14  ILE 14  210 210 ILE ILE A . n 
A 1 15  TYR 15  211 211 TYR TYR A . n 
A 1 16  GLU 16  212 212 GLU GLU A . n 
A 1 17  ALA 17  213 213 ALA ALA A . n 
A 1 18  TYR 18  214 214 TYR TYR A . n 
A 1 19  LEU 19  215 215 LEU LEU A . n 
A 1 20  LYS 20  216 216 LYS LYS A . n 
A 1 21  ASN 21  217 217 ASN ASN A . n 
A 1 22  PHE 22  218 218 PHE PHE A . n 
A 1 23  ASN 23  219 219 ASN ASN A . n 
A 1 24  MET 24  220 220 MET MET A . n 
A 1 25  ASN 25  221 221 ASN ASN A . n 
A 1 26  LYS 26  222 222 LYS LYS A . n 
A 1 27  VAL 27  223 223 VAL VAL A . n 
A 1 28  LYS 28  224 224 LYS LYS A . n 
A 1 29  ALA 29  225 225 ALA ALA A . n 
A 1 30  ARG 30  226 226 ARG ARG A . n 
A 1 31  VAL 31  227 227 VAL VAL A . n 
A 1 32  ILE 32  228 228 ILE ILE A . n 
A 1 33  LEU 33  229 229 LEU LEU A . n 
A 1 34  SER 34  230 230 SER SER A . n 
A 1 35  GLY 35  231 ?   ?   ?   A . n 
A 1 36  LYS 36  232 ?   ?   ?   A . n 
A 1 37  ALA 37  233 ?   ?   ?   A . n 
A 1 38  SER 38  234 ?   ?   ?   A . n 
A 1 39  ASN 39  235 ?   ?   ?   A . n 
A 1 40  ASN 40  236 ?   ?   ?   A . n 
A 1 41  PRO 41  237 ?   ?   ?   A . n 
A 1 42  PRO 42  238 238 PRO PRO A . n 
A 1 43  PHE 43  239 239 PHE PHE A . n 
A 1 44  VAL 44  240 240 VAL VAL A . n 
A 1 45  ILE 45  241 241 ILE ILE A . n 
A 1 46  HIS 46  242 242 HIS HIS A . n 
A 1 47  ASP 47  243 243 ASP ASP A . n 
A 1 48  MET 48  244 244 MET MET A . n 
A 1 49  GLU 49  245 245 GLU GLU A . n 
A 1 50  THR 50  246 246 THR THR A . n 
A 1 51  LEU 51  247 247 LEU LEU A . n 
A 1 52  CYS 52  248 248 CYS CYS A . n 
A 1 53  MET 53  249 249 MET MET A . n 
A 1 54  ALA 54  250 250 ALA ALA A . n 
A 1 55  GLU 55  251 251 GLU GLU A . n 
A 1 56  LYS 56  252 252 LYS LYS A . n 
A 1 57  THR 57  253 253 THR THR A . n 
A 1 58  LEU 58  254 254 LEU LEU A . n 
A 1 59  VAL 59  255 255 VAL VAL A . n 
A 1 60  ALA 60  256 256 ALA ALA A . n 
A 1 61  LYS 61  257 ?   ?   ?   A . n 
A 1 62  LEU 62  258 ?   ?   ?   A . n 
A 1 63  VAL 63  259 ?   ?   ?   A . n 
A 1 64  ALA 64  260 ?   ?   ?   A . n 
A 1 65  ASN 65  261 ?   ?   ?   A . n 
A 1 66  GLY 66  262 ?   ?   ?   A . n 
A 1 67  ILE 67  263 ?   ?   ?   A . n 
A 1 68  GLN 68  264 ?   ?   ?   A . n 
A 1 69  ASN 69  265 265 ASN ASN A . n 
A 1 70  LYS 70  266 266 LYS LYS A . n 
A 1 71  GLU 71  267 267 GLU GLU A . n 
A 1 72  ALA 72  268 268 ALA ALA A . n 
A 1 73  GLU 73  269 269 GLU GLU A . n 
A 1 74  VAL 74  270 270 VAL VAL A . n 
A 1 75  ARG 75  271 271 ARG ARG A . n 
A 1 76  ILE 76  272 272 ILE ILE A . n 
A 1 77  PHE 77  273 273 PHE PHE A . n 
A 1 78  HIS 78  274 274 HIS HIS A . n 
A 1 79  CYS 79  275 275 CYS CYS A . n 
A 1 80  CYS 80  276 276 CYS CYS A . n 
A 1 81  GLN 81  277 277 GLN GLN A . n 
A 1 82  CYS 82  278 278 CYS CYS A . n 
A 1 83  THR 83  279 279 THR THR A . n 
A 1 84  SER 84  280 280 SER SER A . n 
A 1 85  VAL 85  281 281 VAL VAL A . n 
A 1 86  GLU 86  282 282 GLU GLU A . n 
A 1 87  THR 87  283 283 THR THR A . n 
A 1 88  VAL 88  284 284 VAL VAL A . n 
A 1 89  THR 89  285 285 THR THR A . n 
A 1 90  GLU 90  286 286 GLU GLU A . n 
A 1 91  LEU 91  287 287 LEU LEU A . n 
A 1 92  THR 92  288 288 THR THR A . n 
A 1 93  GLU 93  289 289 GLU GLU A . n 
A 1 94  PHE 94  290 290 PHE PHE A . n 
A 1 95  ALA 95  291 291 ALA ALA A . n 
A 1 96  LYS 96  292 292 LYS LYS A . n 
A 1 97  ALA 97  293 293 ALA ALA A . n 
A 1 98  ILE 98  294 294 ILE ILE A . n 
A 1 99  PRO 99  295 295 PRO PRO A . n 
A 1 100 GLY 100 296 296 GLY GLY A . n 
A 1 101 PHE 101 297 297 PHE PHE A . n 
A 1 102 ALA 102 298 298 ALA ALA A . n 
A 1 103 ASN 103 299 299 ASN ASN A . n 
A 1 104 LEU 104 300 300 LEU LEU A . n 
A 1 105 ASP 105 301 301 ASP ASP A . n 
A 1 106 LEU 106 302 302 LEU LEU A . n 
A 1 107 ASN 107 303 303 ASN ASN A . n 
A 1 108 ASP 108 304 304 ASP ASP A . n 
A 1 109 GLN 109 305 305 GLN GLN A . n 
A 1 110 VAL 110 306 306 VAL VAL A . n 
A 1 111 THR 111 307 307 THR THR A . n 
A 1 112 LEU 112 308 308 LEU LEU A . n 
A 1 113 LEU 113 309 309 LEU LEU A . n 
A 1 114 LYS 114 310 310 LYS LYS A . n 
A 1 115 TYR 115 311 311 TYR TYR A . n 
A 1 116 GLY 116 312 312 GLY GLY A . n 
A 1 117 VAL 117 313 313 VAL VAL A . n 
A 1 118 TYR 118 314 314 TYR TYR A . n 
A 1 119 GLU 119 315 315 GLU GLU A . n 
A 1 120 ALA 120 316 316 ALA ALA A . n 
A 1 121 ILE 121 317 317 ILE ILE A . n 
A 1 122 PHE 122 318 318 PHE PHE A . n 
A 1 123 ALA 123 319 319 ALA ALA A . n 
A 1 124 MET 124 320 320 MET MET A . n 
A 1 125 LEU 125 321 321 LEU LEU A . n 
A 1 126 SER 126 322 322 SER SER A . n 
A 1 127 SER 127 323 323 SER SER A . n 
A 1 128 VAL 128 324 324 VAL VAL A . n 
A 1 129 MET 129 325 325 MET MET A . n 
A 1 130 ASN 130 326 326 ASN ASN A . n 
A 1 131 LYS 131 327 327 LYS LYS A . n 
A 1 132 ASP 132 328 328 ASP ASP A . n 
A 1 133 GLY 133 329 329 GLY GLY A . n 
A 1 134 MET 134 330 330 MET MET A . n 
A 1 135 LEU 135 331 331 LEU LEU A . n 
A 1 136 VAL 136 332 332 VAL VAL A . n 
A 1 137 ALA 137 333 333 ALA ALA A . n 
A 1 138 TYR 138 334 334 TYR TYR A . n 
A 1 139 GLY 139 335 335 GLY GLY A . n 
A 1 140 ASN 140 336 336 ASN ASN A . n 
A 1 141 GLY 141 337 337 GLY GLY A . n 
A 1 142 PHE 142 338 338 PHE PHE A . n 
A 1 143 ILE 143 339 339 ILE ILE A . n 
A 1 144 THR 144 340 340 THR THR A . n 
A 1 145 ARG 145 341 341 ARG ARG A . n 
A 1 146 GLU 146 342 342 GLU GLU A . n 
A 1 147 PHE 147 343 343 PHE PHE A . n 
A 1 148 LEU 148 344 344 LEU LEU A . n 
A 1 149 LYS 149 345 345 LYS LYS A . n 
A 1 150 SER 150 346 346 SER SER A . n 
A 1 151 LEU 151 347 347 LEU LEU A . n 
A 1 152 ARG 152 348 348 ARG ARG A . n 
A 1 153 LYS 153 349 349 LYS LYS A . n 
A 1 154 PRO 154 350 350 PRO PRO A . n 
A 1 155 PHE 155 351 351 PHE PHE A . n 
A 1 156 CYS 156 352 352 CYS CYS A . n 
A 1 157 ASP 157 353 353 ASP ASP A . n 
A 1 158 ILE 158 354 354 ILE ILE A . n 
A 1 159 MET 159 355 355 MET MET A . n 
A 1 160 GLU 160 356 356 GLU GLU A . n 
A 1 161 PRO 161 357 357 PRO PRO A . n 
A 1 162 LYS 162 358 358 LYS LYS A . n 
A 1 163 PHE 163 359 359 PHE PHE A . n 
A 1 164 ASP 164 360 360 ASP ASP A . n 
A 1 165 PHE 165 361 361 PHE PHE A . n 
A 1 166 ALA 166 362 362 ALA ALA A . n 
A 1 167 MET 167 363 363 MET MET A . n 
A 1 168 LYS 168 364 364 LYS LYS A . n 
A 1 169 PHE 169 365 365 PHE PHE A . n 
A 1 170 ASN 170 366 366 ASN ASN A . n 
A 1 171 ALA 171 367 367 ALA ALA A . n 
A 1 172 LEU 172 368 368 LEU LEU A . n 
A 1 173 GLU 173 369 369 GLU GLU A . n 
A 1 174 LEU 174 370 370 LEU LEU A . n 
A 1 175 ASP 175 371 371 ASP ASP A . n 
A 1 176 ASP 176 372 372 ASP ASP A . n 
A 1 177 SER 177 373 373 SER SER A . n 
A 1 178 ASP 178 374 374 ASP ASP A . n 
A 1 179 ILE 179 375 375 ILE ILE A . n 
A 1 180 SER 180 376 376 SER SER A . n 
A 1 181 LEU 181 377 377 LEU LEU A . n 
A 1 182 PHE 182 378 378 PHE PHE A . n 
A 1 183 VAL 183 379 379 VAL VAL A . n 
A 1 184 ALA 184 380 380 ALA ALA A . n 
A 1 185 ALA 185 381 381 ALA ALA A . n 
A 1 186 ILE 186 382 382 ILE ILE A . n 
A 1 187 ILE 187 383 383 ILE ILE A . n 
A 1 188 CYS 188 384 384 CYS CYS A . n 
A 1 189 CYS 189 385 385 CYS CYS A . n 
A 1 190 GLY 190 386 386 GLY GLY A . n 
A 1 191 ASP 191 387 387 ASP ASP A . n 
A 1 192 ARG 192 388 388 ARG ARG A . n 
A 1 193 PRO 193 389 389 PRO PRO A . n 
A 1 194 GLY 194 390 390 GLY GLY A . n 
A 1 195 LEU 195 391 391 LEU LEU A . n 
A 1 196 LEU 196 392 392 LEU LEU A . n 
A 1 197 ASN 197 393 393 ASN ASN A . n 
A 1 198 VAL 198 394 394 VAL VAL A . n 
A 1 199 GLY 199 395 395 GLY GLY A . n 
A 1 200 HIS 200 396 396 HIS HIS A . n 
A 1 201 ILE 201 397 397 ILE ILE A . n 
A 1 202 GLU 202 398 398 GLU GLU A . n 
A 1 203 LYS 203 399 399 LYS LYS A . n 
A 1 204 MET 204 400 400 MET MET A . n 
A 1 205 GLN 205 401 401 GLN GLN A . n 
A 1 206 GLU 206 402 402 GLU GLU A . n 
A 1 207 GLY 207 403 403 GLY GLY A . n 
A 1 208 ILE 208 404 404 ILE ILE A . n 
A 1 209 VAL 209 405 405 VAL VAL A . n 
A 1 210 HIS 210 406 406 HIS HIS A . n 
A 1 211 VAL 211 407 407 VAL VAL A . n 
A 1 212 LEU 212 408 408 LEU LEU A . n 
A 1 213 ARG 213 409 409 ARG ARG A . n 
A 1 214 LEU 214 410 410 LEU LEU A . n 
A 1 215 HIS 215 411 411 HIS HIS A . n 
A 1 216 LEU 216 412 412 LEU LEU A . n 
A 1 217 GLN 217 413 413 GLN GLN A . n 
A 1 218 SER 218 414 414 SER SER A . n 
A 1 219 ASN 219 415 415 ASN ASN A . n 
A 1 220 HIS 220 416 416 HIS HIS A . n 
A 1 221 PRO 221 417 417 PRO PRO A . n 
A 1 222 ASP 222 418 418 ASP ASP A . n 
A 1 223 ASP 223 419 419 ASP ASP A . n 
A 1 224 ILE 224 420 420 ILE ILE A . n 
A 1 225 PHE 225 421 421 PHE PHE A . n 
A 1 226 LEU 226 422 422 LEU LEU A . n 
A 1 227 PHE 227 423 423 PHE PHE A . n 
A 1 228 PRO 228 424 424 PRO PRO A . n 
A 1 229 LYS 229 425 425 LYS LYS A . n 
A 1 230 LEU 230 426 426 LEU LEU A . n 
A 1 231 LEU 231 427 427 LEU LEU A . n 
A 1 232 GLN 232 428 428 GLN GLN A . n 
A 1 233 LYS 233 429 429 LYS LYS A . n 
A 1 234 MET 234 430 430 MET MET A . n 
A 1 235 ALA 235 431 431 ALA ALA A . n 
A 1 236 ASP 236 432 432 ASP ASP A . n 
A 1 237 LEU 237 433 433 LEU LEU A . n 
A 1 238 ARG 238 434 434 ARG ARG A . n 
A 1 239 GLN 239 435 435 GLN GLN A . n 
A 1 240 LEU 240 436 436 LEU LEU A . n 
A 1 241 VAL 241 437 437 VAL VAL A . n 
A 1 242 THR 242 438 438 THR THR A . n 
A 1 243 GLU 243 439 439 GLU GLU A . n 
A 1 244 HIS 244 440 440 HIS HIS A . n 
A 1 245 ALA 245 441 441 ALA ALA A . n 
A 1 246 GLN 246 442 442 GLN GLN A . n 
A 1 247 LEU 247 443 443 LEU LEU A . n 
A 1 248 VAL 248 444 444 VAL VAL A . n 
A 1 249 GLN 249 445 445 GLN GLN A . n 
A 1 250 ILE 250 446 446 ILE ILE A . n 
A 1 251 ILE 251 447 447 ILE ILE A . n 
A 1 252 LYS 252 448 448 LYS LYS A . n 
A 1 253 LYS 253 449 449 LYS LYS A . n 
A 1 254 THR 254 450 450 THR THR A . n 
A 1 255 GLU 255 451 451 GLU GLU A . n 
A 1 256 SER 256 452 452 SER SER A . n 
A 1 257 ASP 257 453 453 ASP ASP A . n 
A 1 258 ALA 258 454 454 ALA ALA A . n 
A 1 259 ALA 259 455 455 ALA ALA A . n 
A 1 260 LEU 260 456 456 LEU LEU A . n 
A 1 261 HIS 261 457 457 HIS HIS A . n 
A 1 262 PRO 262 458 458 PRO PRO A . n 
A 1 263 LEU 263 459 459 LEU LEU A . n 
A 1 264 LEU 264 460 460 LEU LEU A . n 
A 1 265 GLN 265 461 461 GLN GLN A . n 
A 1 266 GLU 266 462 462 GLU GLU A . n 
A 1 267 ILE 267 463 463 ILE ILE A . n 
A 1 268 TYR 268 464 464 TYR TYR A . n 
A 1 269 ARG 269 465 465 ARG ARG A . n 
A 1 270 ASP 270 466 466 ASP ASP A . n 
A 1 271 MET 271 467 467 MET MET A . n 
A 1 272 TYR 272 468 ?   ?   ?   A . n 
B 2 1   PRO 1   135 ?   ?   ?   B . n 
B 2 2   GLN 2   136 ?   ?   ?   B . n 
B 2 3   GLU 3   137 ?   ?   ?   B . n 
B 2 4   ALA 4   138 ?   ?   ?   B . n 
B 2 5   GLU 5   139 ?   ?   ?   B . n 
B 2 6   GLU 6   140 ?   ?   ?   B . n 
B 2 7   PRO 7   141 ?   ?   ?   B . n 
B 2 8   SER 8   142 142 SER SER B . n 
B 2 9   LEU 9   143 143 LEU LEU B . n 
B 2 10  LEU 10  144 144 LEU LEU B . n 
B 2 11  LYS 11  145 145 LYS LYS B . n 
B 2 12  LYS 12  146 146 LYS LYS B . n 
B 2 13  LEU 13  147 147 LEU LEU B . n 
B 2 14  LEU 14  148 148 LEU LEU B . n 
B 2 15  LEU 15  149 149 LEU LEU B . n 
B 2 16  ALA 16  150 150 ALA ALA B . n 
B 2 17  PRO 17  151 ?   ?   ?   B . n 
B 2 18  ALA 18  152 ?   ?   ?   B . n 
B 2 19  ASN 19  153 ?   ?   ?   B . n 
B 2 20  THR 20  154 ?   ?   ?   B . n 
B 2 21  GLN 21  155 ?   ?   ?   B . n 
B 2 22  LEU 22  156 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1LZX 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1LZX 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1LZX 1   500 500 A1LZX A02 A . 
D 4 HOH   1   601 75  HOH   HOH A . 
D 4 HOH   2   602 67  HOH   HOH A . 
D 4 HOH   3   603 90  HOH   HOH A . 
D 4 HOH   4   604 81  HOH   HOH A . 
D 4 HOH   5   605 29  HOH   HOH A . 
D 4 HOH   6   606 83  HOH   HOH A . 
D 4 HOH   7   607 15  HOH   HOH A . 
D 4 HOH   8   608 10  HOH   HOH A . 
D 4 HOH   9   609 39  HOH   HOH A . 
D 4 HOH   10  610 58  HOH   HOH A . 
D 4 HOH   11  611 24  HOH   HOH A . 
D 4 HOH   12  612 5   HOH   HOH A . 
D 4 HOH   13  613 65  HOH   HOH A . 
D 4 HOH   14  614 43  HOH   HOH A . 
D 4 HOH   15  615 21  HOH   HOH A . 
D 4 HOH   16  616 32  HOH   HOH A . 
D 4 HOH   17  617 3   HOH   HOH A . 
D 4 HOH   18  618 33  HOH   HOH A . 
D 4 HOH   19  619 62  HOH   HOH A . 
D 4 HOH   20  620 4   HOH   HOH A . 
D 4 HOH   21  621 36  HOH   HOH A . 
D 4 HOH   22  622 26  HOH   HOH A . 
D 4 HOH   23  623 52  HOH   HOH A . 
D 4 HOH   24  624 8   HOH   HOH A . 
D 4 HOH   25  625 16  HOH   HOH A . 
D 4 HOH   26  626 93  HOH   HOH A . 
D 4 HOH   27  627 66  HOH   HOH A . 
D 4 HOH   28  628 61  HOH   HOH A . 
D 4 HOH   29  629 14  HOH   HOH A . 
D 4 HOH   30  630 103 HOH   HOH A . 
D 4 HOH   31  631 19  HOH   HOH A . 
D 4 HOH   32  632 41  HOH   HOH A . 
D 4 HOH   33  633 73  HOH   HOH A . 
D 4 HOH   34  634 1   HOH   HOH A . 
D 4 HOH   35  635 42  HOH   HOH A . 
D 4 HOH   36  636 99  HOH   HOH A . 
D 4 HOH   37  637 77  HOH   HOH A . 
D 4 HOH   38  638 79  HOH   HOH A . 
D 4 HOH   39  639 91  HOH   HOH A . 
D 4 HOH   40  640 96  HOH   HOH A . 
D 4 HOH   41  641 53  HOH   HOH A . 
D 4 HOH   42  642 25  HOH   HOH A . 
D 4 HOH   43  643 60  HOH   HOH A . 
D 4 HOH   44  644 59  HOH   HOH A . 
D 4 HOH   45  645 34  HOH   HOH A . 
D 4 HOH   46  646 101 HOH   HOH A . 
D 4 HOH   47  647 7   HOH   HOH A . 
D 4 HOH   48  648 30  HOH   HOH A . 
D 4 HOH   49  649 56  HOH   HOH A . 
D 4 HOH   50  650 45  HOH   HOH A . 
D 4 HOH   51  651 88  HOH   HOH A . 
D 4 HOH   52  652 22  HOH   HOH A . 
D 4 HOH   53  653 85  HOH   HOH A . 
D 4 HOH   54  654 50  HOH   HOH A . 
D 4 HOH   55  655 40  HOH   HOH A . 
D 4 HOH   56  656 13  HOH   HOH A . 
D 4 HOH   57  657 2   HOH   HOH A . 
D 4 HOH   58  658 18  HOH   HOH A . 
D 4 HOH   59  659 57  HOH   HOH A . 
D 4 HOH   60  660 70  HOH   HOH A . 
D 4 HOH   61  661 82  HOH   HOH A . 
D 4 HOH   62  662 44  HOH   HOH A . 
D 4 HOH   63  663 55  HOH   HOH A . 
D 4 HOH   64  664 27  HOH   HOH A . 
D 4 HOH   65  665 46  HOH   HOH A . 
D 4 HOH   66  666 6   HOH   HOH A . 
D 4 HOH   67  667 87  HOH   HOH A . 
D 4 HOH   68  668 69  HOH   HOH A . 
D 4 HOH   69  669 95  HOH   HOH A . 
D 4 HOH   70  670 78  HOH   HOH A . 
D 4 HOH   71  671 12  HOH   HOH A . 
D 4 HOH   72  672 80  HOH   HOH A . 
D 4 HOH   73  673 11  HOH   HOH A . 
D 4 HOH   74  674 72  HOH   HOH A . 
D 4 HOH   75  675 31  HOH   HOH A . 
D 4 HOH   76  676 28  HOH   HOH A . 
D 4 HOH   77  677 64  HOH   HOH A . 
D 4 HOH   78  678 105 HOH   HOH A . 
D 4 HOH   79  679 51  HOH   HOH A . 
D 4 HOH   80  680 86  HOH   HOH A . 
D 4 HOH   81  681 37  HOH   HOH A . 
D 4 HOH   82  682 35  HOH   HOH A . 
D 4 HOH   83  683 104 HOH   HOH A . 
D 4 HOH   84  684 54  HOH   HOH A . 
D 4 HOH   85  685 17  HOH   HOH A . 
D 4 HOH   86  686 9   HOH   HOH A . 
D 4 HOH   87  687 76  HOH   HOH A . 
D 4 HOH   88  688 74  HOH   HOH A . 
D 4 HOH   89  689 102 HOH   HOH A . 
D 4 HOH   90  690 94  HOH   HOH A . 
D 4 HOH   91  691 68  HOH   HOH A . 
D 4 HOH   92  692 92  HOH   HOH A . 
D 4 HOH   93  693 100 HOH   HOH A . 
D 4 HOH   94  694 49  HOH   HOH A . 
D 4 HOH   95  695 48  HOH   HOH A . 
D 4 HOH   96  696 98  HOH   HOH A . 
D 4 HOH   97  697 89  HOH   HOH A . 
D 4 HOH   98  698 97  HOH   HOH A . 
D 4 HOH   99  699 47  HOH   HOH A . 
D 4 HOH   100 700 84  HOH   HOH A . 
D 4 HOH   101 701 38  HOH   HOH A . 
D 4 HOH   102 702 23  HOH   HOH A . 
D 4 HOH   103 703 20  HOH   HOH A . 
D 4 HOH   104 704 63  HOH   HOH A . 
D 4 HOH   105 705 71  HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YT6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.647 
_cell.length_a_esd                 ? 
_cell.length_b                     61.305 
_cell.length_b_esd                 ? 
_cell.length_c                     100.651 
_cell.length_c_esd                 ? 
_cell.volume                       281660.685 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YT6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YT6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.13 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.20 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES-NaOH, 19-23% PEG 4000, 19-23% 1,2-propanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER R 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-07-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL26B1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL26B1 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          36.40 
_reflns.entry_id                                       8YT6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.85 
_reflns.d_resolution_low                               45.65 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24883 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          17.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.085 
_reflns.pdbx_Rpim_I_all                                0.023 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       325262 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.081 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.85 
_reflns_shell.d_res_low                                     1.89 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           20946 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1521 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.6 
_reflns_shell.pdbx_Rrim_I_all                               1.918 
_reflns_shell.pdbx_Rpim_I_all                               0.511 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.653 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.847 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               40.32 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YT6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.85 
_refine.ls_d_res_low                             38.90 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     24828 
_refine.ls_number_reflns_R_free                  2490 
_refine.ls_number_reflns_R_work                  22338 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.98 
_refine.ls_percent_reflns_R_free                 10.03 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2355 
_refine.ls_R_factor_R_free                       0.2651 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2321 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.6329 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3039 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.85 
_refine_hist.d_res_low                        38.90 
_refine_hist.number_atoms_solvent             105 
_refine_hist.number_atoms_total               2203 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2069 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0040  ? 2133 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5913  ? 2870 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0425  ? 332  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0042  ? 357  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 19.2891 ? 799  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.85 1.89  . . 156 1197 100.00 . . . . 0.4112 . . . . . . . . . . . 0.4296 
'X-RAY DIFFRACTION' 1.89 1.92  . . 122 1244 100.00 . . . . 0.3480 . . . . . . . . . . . 0.3346 
'X-RAY DIFFRACTION' 1.92 1.97  . . 149 1205 100.00 . . . . 0.3364 . . . . . . . . . . . 0.3623 
'X-RAY DIFFRACTION' 1.97 2.01  . . 127 1238 100.00 . . . . 0.3241 . . . . . . . . . . . 0.3646 
'X-RAY DIFFRACTION' 2.01 2.06  . . 132 1220 100.00 . . . . 0.2852 . . . . . . . . . . . 0.3798 
'X-RAY DIFFRACTION' 2.06 2.12  . . 139 1218 100.00 . . . . 0.2800 . . . . . . . . . . . 0.2997 
'X-RAY DIFFRACTION' 2.12 2.18  . . 136 1237 100.00 . . . . 0.2923 . . . . . . . . . . . 0.3160 
'X-RAY DIFFRACTION' 2.18 2.25  . . 114 1229 100.00 . . . . 0.2820 . . . . . . . . . . . 0.3286 
'X-RAY DIFFRACTION' 2.25 2.33  . . 137 1226 100.00 . . . . 0.2761 . . . . . . . . . . . 0.3098 
'X-RAY DIFFRACTION' 2.33 2.42  . . 152 1213 100.00 . . . . 0.2516 . . . . . . . . . . . 0.2906 
'X-RAY DIFFRACTION' 2.42 2.53  . . 135 1247 100.00 . . . . 0.2498 . . . . . . . . . . . 0.2943 
'X-RAY DIFFRACTION' 2.53 2.67  . . 134 1240 100.00 . . . . 0.2615 . . . . . . . . . . . 0.2896 
'X-RAY DIFFRACTION' 2.67 2.83  . . 136 1243 100.00 . . . . 0.2562 . . . . . . . . . . . 0.2983 
'X-RAY DIFFRACTION' 2.84 3.05  . . 158 1233 100.00 . . . . 0.2606 . . . . . . . . . . . 0.3218 
'X-RAY DIFFRACTION' 3.05 3.36  . . 119 1256 99.93  . . . . 0.2373 . . . . . . . . . . . 0.2795 
'X-RAY DIFFRACTION' 3.36 3.85  . . 136 1277 100.00 . . . . 0.2072 . . . . . . . . . . . 0.2298 
'X-RAY DIFFRACTION' 3.85 4.85  . . 149 1269 100.00 . . . . 0.1768 . . . . . . . . . . . 0.2304 
'X-RAY DIFFRACTION' 4.85 38.90 . . 159 1346 99.80  . . . . 0.1982 . . . . . . . . . . . 0.1991 
# 
_struct.entry_id                     8YT6 
_struct.title                        
'Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YT6 
_struct_keywords.text            'Agonist, Complex, Nuclear receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARA_HUMAN Q07869 ? 1 
;TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
;
200 
2 UNP PRGC1_HUMAN Q9UBK2 ? 2 PQEAEEPSLLKKLLLAPANTQL 135 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YT6 A 4 ? 272 ? Q07869 200 ? 468 ? 200 468 
2 2 8YT6 B 1 ? 22  ? Q9UBK2 135 ? 156 ? 135 156 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YT6 GLY A 1 ? UNP Q07869 ? ? 'expression tag' 197 1 
1 8YT6 GLY A 2 ? UNP Q07869 ? ? 'expression tag' 198 2 
1 8YT6 GLN A 3 ? UNP Q07869 ? ? 'expression tag' 199 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1050  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  12490 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? PHE A 22  ? SER A 205 PHE A 218 1 ? 14 
HELX_P HELX_P2  AA2 ASN A 25  ? SER A 34  ? ASN A 221 SER A 230 1 ? 10 
HELX_P HELX_P3  AA3 ASP A 47  ? VAL A 59  ? ASP A 243 VAL A 255 1 ? 13 
HELX_P HELX_P4  AA4 GLU A 71  ? ILE A 98  ? GLU A 267 ILE A 294 1 ? 28 
HELX_P HELX_P5  AA5 ASP A 105 ? SER A 126 ? ASP A 301 SER A 322 1 ? 22 
HELX_P HELX_P6  AA6 SER A 127 ? MET A 129 ? SER A 323 MET A 325 5 ? 3  
HELX_P HELX_P7  AA7 ARG A 145 ? SER A 150 ? ARG A 341 SER A 346 1 ? 6  
HELX_P HELX_P8  AA8 PRO A 154 ? ILE A 158 ? PRO A 350 ILE A 354 5 ? 5  
HELX_P HELX_P9  AA9 MET A 159 ? LEU A 172 ? MET A 355 LEU A 368 1 ? 14 
HELX_P HELX_P10 AB1 ASP A 175 ? CYS A 188 ? ASP A 371 CYS A 384 1 ? 14 
HELX_P HELX_P11 AB2 ASN A 197 ? HIS A 220 ? ASN A 393 HIS A 416 1 ? 24 
HELX_P HELX_P12 AB3 PHE A 225 ? GLU A 255 ? PHE A 421 GLU A 451 1 ? 31 
HELX_P HELX_P13 AB4 HIS A 261 ? ARG A 269 ? HIS A 457 ARG A 465 1 ? 9  
HELX_P HELX_P14 AB5 LEU B 9   ? LEU B 15  ? LEU B 143 LEU B 149 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           153 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            349 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    154 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     350 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.54 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 43  ? ILE A 45  ? PHE A 239 ILE A 241 
AA1 2 GLY A 141 ? THR A 144 ? GLY A 337 THR A 340 
AA1 3 GLY A 133 ? VAL A 136 ? GLY A 329 VAL A 332 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 45  ? N ILE A 241 O PHE A 142 ? O PHE A 338 
AA1 2 3 O GLY A 141 ? O GLY A 337 N VAL A 136 ? N VAL A 332 
# 
_pdbx_entry_details.entry_id                   8YT6 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    LEU 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     392 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -84.48 
_pdbx_validate_torsion.psi             -70.48 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 197 ? A GLY 1   
2  1 Y 1 A GLY 198 ? A GLY 2   
3  1 Y 1 A GLN 199 ? A GLN 3   
4  1 Y 1 A THR 200 ? A THR 4   
5  1 Y 1 A ALA 201 ? A ALA 5   
6  1 Y 1 A GLY 231 ? A GLY 35  
7  1 Y 1 A LYS 232 ? A LYS 36  
8  1 Y 1 A ALA 233 ? A ALA 37  
9  1 Y 1 A SER 234 ? A SER 38  
10 1 Y 1 A ASN 235 ? A ASN 39  
11 1 Y 1 A ASN 236 ? A ASN 40  
12 1 Y 1 A PRO 237 ? A PRO 41  
13 1 Y 1 A LYS 257 ? A LYS 61  
14 1 Y 1 A LEU 258 ? A LEU 62  
15 1 Y 1 A VAL 259 ? A VAL 63  
16 1 Y 1 A ALA 260 ? A ALA 64  
17 1 Y 1 A ASN 261 ? A ASN 65  
18 1 Y 1 A GLY 262 ? A GLY 66  
19 1 Y 1 A ILE 263 ? A ILE 67  
20 1 Y 1 A GLN 264 ? A GLN 68  
21 1 Y 1 A TYR 468 ? A TYR 272 
22 1 Y 1 B PRO 135 ? B PRO 1   
23 1 Y 1 B GLN 136 ? B GLN 2   
24 1 Y 1 B GLU 137 ? B GLU 3   
25 1 Y 1 B ALA 138 ? B ALA 4   
26 1 Y 1 B GLU 139 ? B GLU 5   
27 1 Y 1 B GLU 140 ? B GLU 6   
28 1 Y 1 B PRO 141 ? B PRO 7   
29 1 Y 1 B PRO 151 ? B PRO 17  
30 1 Y 1 B ALA 152 ? B ALA 18  
31 1 Y 1 B ASN 153 ? B ASN 19  
32 1 Y 1 B THR 154 ? B THR 20  
33 1 Y 1 B GLN 155 ? B GLN 21  
34 1 Y 1 B LEU 156 ? B LEU 22  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LZX C01  C Y N 1   
A1LZX C02  C Y N 2   
A1LZX C03  C Y N 3   
A1LZX C04  C Y N 4   
A1LZX C05  C Y N 5   
A1LZX C06  C Y N 6   
A1LZX C07  C N N 7   
A1LZX C08  C N N 8   
A1LZX C09  C N N 9   
A1LZX C10  C N N 10  
A1LZX C11  C N N 11  
A1LZX C12  C N N 12  
A1LZX C13  C N N 13  
A1LZX C14  C Y N 14  
A1LZX C15  C Y N 15  
A1LZX C16  C Y N 16  
A1LZX C17  C Y N 17  
A1LZX C18  C Y N 18  
A1LZX C19  C Y N 19  
A1LZX C26  C N N 20  
A1LZX C28  C N N 21  
A1LZX C29  C N N 22  
A1LZX F20  F N N 23  
A1LZX N21  N Y N 24  
A1LZX N22  N Y N 25  
A1LZX N23  N Y N 26  
A1LZX O24  O N N 27  
A1LZX O25  O N N 28  
A1LZX O27  O N N 29  
A1LZX H1   H N N 30  
A1LZX H2   H N N 31  
A1LZX H3   H N N 32  
A1LZX H4   H N N 33  
A1LZX H5   H N N 34  
A1LZX H6   H N N 35  
A1LZX H7   H N N 36  
A1LZX H8   H N N 37  
A1LZX H9   H N N 38  
A1LZX H10  H N N 39  
A1LZX H11  H N N 40  
A1LZX H12  H N N 41  
A1LZX H13  H N N 42  
A1LZX H14  H N N 43  
A1LZX H15  H N N 44  
A1LZX H16  H N N 45  
A1LZX H17  H N N 46  
A1LZX H18  H N N 47  
A1LZX H19  H N N 48  
A1LZX H20  H N N 49  
A1LZX H21  H N N 50  
A1LZX H22  H N N 51  
A1LZX H23  H N N 52  
A1LZX H24  H N N 53  
A1LZX H25  H N N 54  
A1LZX H26  H N N 55  
ALA   N    N N N 56  
ALA   CA   C N S 57  
ALA   C    C N N 58  
ALA   O    O N N 59  
ALA   CB   C N N 60  
ALA   OXT  O N N 61  
ALA   H    H N N 62  
ALA   H2   H N N 63  
ALA   HA   H N N 64  
ALA   HB1  H N N 65  
ALA   HB2  H N N 66  
ALA   HB3  H N N 67  
ALA   HXT  H N N 68  
ARG   N    N N N 69  
ARG   CA   C N S 70  
ARG   C    C N N 71  
ARG   O    O N N 72  
ARG   CB   C N N 73  
ARG   CG   C N N 74  
ARG   CD   C N N 75  
ARG   NE   N N N 76  
ARG   CZ   C N N 77  
ARG   NH1  N N N 78  
ARG   NH2  N N N 79  
ARG   OXT  O N N 80  
ARG   H    H N N 81  
ARG   H2   H N N 82  
ARG   HA   H N N 83  
ARG   HB2  H N N 84  
ARG   HB3  H N N 85  
ARG   HG2  H N N 86  
ARG   HG3  H N N 87  
ARG   HD2  H N N 88  
ARG   HD3  H N N 89  
ARG   HE   H N N 90  
ARG   HH11 H N N 91  
ARG   HH12 H N N 92  
ARG   HH21 H N N 93  
ARG   HH22 H N N 94  
ARG   HXT  H N N 95  
ASN   N    N N N 96  
ASN   CA   C N S 97  
ASN   C    C N N 98  
ASN   O    O N N 99  
ASN   CB   C N N 100 
ASN   CG   C N N 101 
ASN   OD1  O N N 102 
ASN   ND2  N N N 103 
ASN   OXT  O N N 104 
ASN   H    H N N 105 
ASN   H2   H N N 106 
ASN   HA   H N N 107 
ASN   HB2  H N N 108 
ASN   HB3  H N N 109 
ASN   HD21 H N N 110 
ASN   HD22 H N N 111 
ASN   HXT  H N N 112 
ASP   N    N N N 113 
ASP   CA   C N S 114 
ASP   C    C N N 115 
ASP   O    O N N 116 
ASP   CB   C N N 117 
ASP   CG   C N N 118 
ASP   OD1  O N N 119 
ASP   OD2  O N N 120 
ASP   OXT  O N N 121 
ASP   H    H N N 122 
ASP   H2   H N N 123 
ASP   HA   H N N 124 
ASP   HB2  H N N 125 
ASP   HB3  H N N 126 
ASP   HD2  H N N 127 
ASP   HXT  H N N 128 
CYS   N    N N N 129 
CYS   CA   C N R 130 
CYS   C    C N N 131 
CYS   O    O N N 132 
CYS   CB   C N N 133 
CYS   SG   S N N 134 
CYS   OXT  O N N 135 
CYS   H    H N N 136 
CYS   H2   H N N 137 
CYS   HA   H N N 138 
CYS   HB2  H N N 139 
CYS   HB3  H N N 140 
CYS   HG   H N N 141 
CYS   HXT  H N N 142 
GLN   N    N N N 143 
GLN   CA   C N S 144 
GLN   C    C N N 145 
GLN   O    O N N 146 
GLN   CB   C N N 147 
GLN   CG   C N N 148 
GLN   CD   C N N 149 
GLN   OE1  O N N 150 
GLN   NE2  N N N 151 
GLN   OXT  O N N 152 
GLN   H    H N N 153 
GLN   H2   H N N 154 
GLN   HA   H N N 155 
GLN   HB2  H N N 156 
GLN   HB3  H N N 157 
GLN   HG2  H N N 158 
GLN   HG3  H N N 159 
GLN   HE21 H N N 160 
GLN   HE22 H N N 161 
GLN   HXT  H N N 162 
GLU   N    N N N 163 
GLU   CA   C N S 164 
GLU   C    C N N 165 
GLU   O    O N N 166 
GLU   CB   C N N 167 
GLU   CG   C N N 168 
GLU   CD   C N N 169 
GLU   OE1  O N N 170 
GLU   OE2  O N N 171 
GLU   OXT  O N N 172 
GLU   H    H N N 173 
GLU   H2   H N N 174 
GLU   HA   H N N 175 
GLU   HB2  H N N 176 
GLU   HB3  H N N 177 
GLU   HG2  H N N 178 
GLU   HG3  H N N 179 
GLU   HE2  H N N 180 
GLU   HXT  H N N 181 
GLY   N    N N N 182 
GLY   CA   C N N 183 
GLY   C    C N N 184 
GLY   O    O N N 185 
GLY   OXT  O N N 186 
GLY   H    H N N 187 
GLY   H2   H N N 188 
GLY   HA2  H N N 189 
GLY   HA3  H N N 190 
GLY   HXT  H N N 191 
HIS   N    N N N 192 
HIS   CA   C N S 193 
HIS   C    C N N 194 
HIS   O    O N N 195 
HIS   CB   C N N 196 
HIS   CG   C Y N 197 
HIS   ND1  N Y N 198 
HIS   CD2  C Y N 199 
HIS   CE1  C Y N 200 
HIS   NE2  N Y N 201 
HIS   OXT  O N N 202 
HIS   H    H N N 203 
HIS   H2   H N N 204 
HIS   HA   H N N 205 
HIS   HB2  H N N 206 
HIS   HB3  H N N 207 
HIS   HD1  H N N 208 
HIS   HD2  H N N 209 
HIS   HE1  H N N 210 
HIS   HE2  H N N 211 
HIS   HXT  H N N 212 
HOH   O    O N N 213 
HOH   H1   H N N 214 
HOH   H2   H N N 215 
ILE   N    N N N 216 
ILE   CA   C N S 217 
ILE   C    C N N 218 
ILE   O    O N N 219 
ILE   CB   C N S 220 
ILE   CG1  C N N 221 
ILE   CG2  C N N 222 
ILE   CD1  C N N 223 
ILE   OXT  O N N 224 
ILE   H    H N N 225 
ILE   H2   H N N 226 
ILE   HA   H N N 227 
ILE   HB   H N N 228 
ILE   HG12 H N N 229 
ILE   HG13 H N N 230 
ILE   HG21 H N N 231 
ILE   HG22 H N N 232 
ILE   HG23 H N N 233 
ILE   HD11 H N N 234 
ILE   HD12 H N N 235 
ILE   HD13 H N N 236 
ILE   HXT  H N N 237 
LEU   N    N N N 238 
LEU   CA   C N S 239 
LEU   C    C N N 240 
LEU   O    O N N 241 
LEU   CB   C N N 242 
LEU   CG   C N N 243 
LEU   CD1  C N N 244 
LEU   CD2  C N N 245 
LEU   OXT  O N N 246 
LEU   H    H N N 247 
LEU   H2   H N N 248 
LEU   HA   H N N 249 
LEU   HB2  H N N 250 
LEU   HB3  H N N 251 
LEU   HG   H N N 252 
LEU   HD11 H N N 253 
LEU   HD12 H N N 254 
LEU   HD13 H N N 255 
LEU   HD21 H N N 256 
LEU   HD22 H N N 257 
LEU   HD23 H N N 258 
LEU   HXT  H N N 259 
LYS   N    N N N 260 
LYS   CA   C N S 261 
LYS   C    C N N 262 
LYS   O    O N N 263 
LYS   CB   C N N 264 
LYS   CG   C N N 265 
LYS   CD   C N N 266 
LYS   CE   C N N 267 
LYS   NZ   N N N 268 
LYS   OXT  O N N 269 
LYS   H    H N N 270 
LYS   H2   H N N 271 
LYS   HA   H N N 272 
LYS   HB2  H N N 273 
LYS   HB3  H N N 274 
LYS   HG2  H N N 275 
LYS   HG3  H N N 276 
LYS   HD2  H N N 277 
LYS   HD3  H N N 278 
LYS   HE2  H N N 279 
LYS   HE3  H N N 280 
LYS   HZ1  H N N 281 
LYS   HZ2  H N N 282 
LYS   HZ3  H N N 283 
LYS   HXT  H N N 284 
MET   N    N N N 285 
MET   CA   C N S 286 
MET   C    C N N 287 
MET   O    O N N 288 
MET   CB   C N N 289 
MET   CG   C N N 290 
MET   SD   S N N 291 
MET   CE   C N N 292 
MET   OXT  O N N 293 
MET   H    H N N 294 
MET   H2   H N N 295 
MET   HA   H N N 296 
MET   HB2  H N N 297 
MET   HB3  H N N 298 
MET   HG2  H N N 299 
MET   HG3  H N N 300 
MET   HE1  H N N 301 
MET   HE2  H N N 302 
MET   HE3  H N N 303 
MET   HXT  H N N 304 
PHE   N    N N N 305 
PHE   CA   C N S 306 
PHE   C    C N N 307 
PHE   O    O N N 308 
PHE   CB   C N N 309 
PHE   CG   C Y N 310 
PHE   CD1  C Y N 311 
PHE   CD2  C Y N 312 
PHE   CE1  C Y N 313 
PHE   CE2  C Y N 314 
PHE   CZ   C Y N 315 
PHE   OXT  O N N 316 
PHE   H    H N N 317 
PHE   H2   H N N 318 
PHE   HA   H N N 319 
PHE   HB2  H N N 320 
PHE   HB3  H N N 321 
PHE   HD1  H N N 322 
PHE   HD2  H N N 323 
PHE   HE1  H N N 324 
PHE   HE2  H N N 325 
PHE   HZ   H N N 326 
PHE   HXT  H N N 327 
PRO   N    N N N 328 
PRO   CA   C N S 329 
PRO   C    C N N 330 
PRO   O    O N N 331 
PRO   CB   C N N 332 
PRO   CG   C N N 333 
PRO   CD   C N N 334 
PRO   OXT  O N N 335 
PRO   H    H N N 336 
PRO   HA   H N N 337 
PRO   HB2  H N N 338 
PRO   HB3  H N N 339 
PRO   HG2  H N N 340 
PRO   HG3  H N N 341 
PRO   HD2  H N N 342 
PRO   HD3  H N N 343 
PRO   HXT  H N N 344 
SER   N    N N N 345 
SER   CA   C N S 346 
SER   C    C N N 347 
SER   O    O N N 348 
SER   CB   C N N 349 
SER   OG   O N N 350 
SER   OXT  O N N 351 
SER   H    H N N 352 
SER   H2   H N N 353 
SER   HA   H N N 354 
SER   HB2  H N N 355 
SER   HB3  H N N 356 
SER   HG   H N N 357 
SER   HXT  H N N 358 
THR   N    N N N 359 
THR   CA   C N S 360 
THR   C    C N N 361 
THR   O    O N N 362 
THR   CB   C N R 363 
THR   OG1  O N N 364 
THR   CG2  C N N 365 
THR   OXT  O N N 366 
THR   H    H N N 367 
THR   H2   H N N 368 
THR   HA   H N N 369 
THR   HB   H N N 370 
THR   HG1  H N N 371 
THR   HG21 H N N 372 
THR   HG22 H N N 373 
THR   HG23 H N N 374 
THR   HXT  H N N 375 
TYR   N    N N N 376 
TYR   CA   C N S 377 
TYR   C    C N N 378 
TYR   O    O N N 379 
TYR   CB   C N N 380 
TYR   CG   C Y N 381 
TYR   CD1  C Y N 382 
TYR   CD2  C Y N 383 
TYR   CE1  C Y N 384 
TYR   CE2  C Y N 385 
TYR   CZ   C Y N 386 
TYR   OH   O N N 387 
TYR   OXT  O N N 388 
TYR   H    H N N 389 
TYR   H2   H N N 390 
TYR   HA   H N N 391 
TYR   HB2  H N N 392 
TYR   HB3  H N N 393 
TYR   HD1  H N N 394 
TYR   HD2  H N N 395 
TYR   HE1  H N N 396 
TYR   HE2  H N N 397 
TYR   HH   H N N 398 
TYR   HXT  H N N 399 
VAL   N    N N N 400 
VAL   CA   C N S 401 
VAL   C    C N N 402 
VAL   O    O N N 403 
VAL   CB   C N N 404 
VAL   CG1  C N N 405 
VAL   CG2  C N N 406 
VAL   OXT  O N N 407 
VAL   H    H N N 408 
VAL   H2   H N N 409 
VAL   HA   H N N 410 
VAL   HB   H N N 411 
VAL   HG11 H N N 412 
VAL   HG12 H N N 413 
VAL   HG13 H N N 414 
VAL   HG21 H N N 415 
VAL   HG22 H N N 416 
VAL   HG23 H N N 417 
VAL   HXT  H N N 418 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LZX C01 C02  doub Y N 1   
A1LZX C01 C07  sing N N 2   
A1LZX C01 N21  sing Y N 3   
A1LZX C02 C03  sing Y N 4   
A1LZX C03 C04  doub Y N 5   
A1LZX C03 C08  sing N N 6   
A1LZX C04 C05  sing Y N 7   
A1LZX C04 C06  sing Y N 8   
A1LZX C05 N21  doub Y N 9   
A1LZX C05 N23  sing Y N 10  
A1LZX C06 C09  sing N N 11  
A1LZX C06 N22  doub Y N 12  
A1LZX C08 O24  doub N N 13  
A1LZX C08 O25  sing N N 14  
A1LZX C09 C10  sing N N 15  
A1LZX C09 C11  sing N N 16  
A1LZX C10 C12  sing N N 17  
A1LZX C11 C13  sing N N 18  
A1LZX C14 C15  doub Y N 19  
A1LZX C14 C19  sing Y N 20  
A1LZX C15 C16  sing Y N 21  
A1LZX C16 C17  doub Y N 22  
A1LZX C16 F20  sing N N 23  
A1LZX C17 C18  sing Y N 24  
A1LZX C18 C19  doub Y N 25  
A1LZX C19 N23  sing N N 26  
A1LZX N22 N23  sing Y N 27  
A1LZX C26 O27  sing N N 28  
A1LZX O27 C28  sing N N 29  
A1LZX C28 C29  sing N N 30  
A1LZX C07 C26  sing N N 31  
A1LZX C02 H1   sing N N 32  
A1LZX C07 H2   sing N N 33  
A1LZX C07 H3   sing N N 34  
A1LZX C09 H4   sing N N 35  
A1LZX C10 H5   sing N N 36  
A1LZX C10 H6   sing N N 37  
A1LZX C11 H7   sing N N 38  
A1LZX C11 H8   sing N N 39  
A1LZX C12 H9   sing N N 40  
A1LZX C12 H10  sing N N 41  
A1LZX C12 H11  sing N N 42  
A1LZX C13 H12  sing N N 43  
A1LZX C13 H13  sing N N 44  
A1LZX C13 H14  sing N N 45  
A1LZX C14 H15  sing N N 46  
A1LZX C15 H16  sing N N 47  
A1LZX C17 H17  sing N N 48  
A1LZX C18 H18  sing N N 49  
A1LZX C26 H19  sing N N 50  
A1LZX C26 H20  sing N N 51  
A1LZX C28 H21  sing N N 52  
A1LZX C28 H22  sing N N 53  
A1LZX C29 H23  sing N N 54  
A1LZX C29 H24  sing N N 55  
A1LZX C29 H25  sing N N 56  
A1LZX O25 H26  sing N N 57  
ALA   N   CA   sing N N 58  
ALA   N   H    sing N N 59  
ALA   N   H2   sing N N 60  
ALA   CA  C    sing N N 61  
ALA   CA  CB   sing N N 62  
ALA   CA  HA   sing N N 63  
ALA   C   O    doub N N 64  
ALA   C   OXT  sing N N 65  
ALA   CB  HB1  sing N N 66  
ALA   CB  HB2  sing N N 67  
ALA   CB  HB3  sing N N 68  
ALA   OXT HXT  sing N N 69  
ARG   N   CA   sing N N 70  
ARG   N   H    sing N N 71  
ARG   N   H2   sing N N 72  
ARG   CA  C    sing N N 73  
ARG   CA  CB   sing N N 74  
ARG   CA  HA   sing N N 75  
ARG   C   O    doub N N 76  
ARG   C   OXT  sing N N 77  
ARG   CB  CG   sing N N 78  
ARG   CB  HB2  sing N N 79  
ARG   CB  HB3  sing N N 80  
ARG   CG  CD   sing N N 81  
ARG   CG  HG2  sing N N 82  
ARG   CG  HG3  sing N N 83  
ARG   CD  NE   sing N N 84  
ARG   CD  HD2  sing N N 85  
ARG   CD  HD3  sing N N 86  
ARG   NE  CZ   sing N N 87  
ARG   NE  HE   sing N N 88  
ARG   CZ  NH1  sing N N 89  
ARG   CZ  NH2  doub N N 90  
ARG   NH1 HH11 sing N N 91  
ARG   NH1 HH12 sing N N 92  
ARG   NH2 HH21 sing N N 93  
ARG   NH2 HH22 sing N N 94  
ARG   OXT HXT  sing N N 95  
ASN   N   CA   sing N N 96  
ASN   N   H    sing N N 97  
ASN   N   H2   sing N N 98  
ASN   CA  C    sing N N 99  
ASN   CA  CB   sing N N 100 
ASN   CA  HA   sing N N 101 
ASN   C   O    doub N N 102 
ASN   C   OXT  sing N N 103 
ASN   CB  CG   sing N N 104 
ASN   CB  HB2  sing N N 105 
ASN   CB  HB3  sing N N 106 
ASN   CG  OD1  doub N N 107 
ASN   CG  ND2  sing N N 108 
ASN   ND2 HD21 sing N N 109 
ASN   ND2 HD22 sing N N 110 
ASN   OXT HXT  sing N N 111 
ASP   N   CA   sing N N 112 
ASP   N   H    sing N N 113 
ASP   N   H2   sing N N 114 
ASP   CA  C    sing N N 115 
ASP   CA  CB   sing N N 116 
ASP   CA  HA   sing N N 117 
ASP   C   O    doub N N 118 
ASP   C   OXT  sing N N 119 
ASP   CB  CG   sing N N 120 
ASP   CB  HB2  sing N N 121 
ASP   CB  HB3  sing N N 122 
ASP   CG  OD1  doub N N 123 
ASP   CG  OD2  sing N N 124 
ASP   OD2 HD2  sing N N 125 
ASP   OXT HXT  sing N N 126 
CYS   N   CA   sing N N 127 
CYS   N   H    sing N N 128 
CYS   N   H2   sing N N 129 
CYS   CA  C    sing N N 130 
CYS   CA  CB   sing N N 131 
CYS   CA  HA   sing N N 132 
CYS   C   O    doub N N 133 
CYS   C   OXT  sing N N 134 
CYS   CB  SG   sing N N 135 
CYS   CB  HB2  sing N N 136 
CYS   CB  HB3  sing N N 137 
CYS   SG  HG   sing N N 138 
CYS   OXT HXT  sing N N 139 
GLN   N   CA   sing N N 140 
GLN   N   H    sing N N 141 
GLN   N   H2   sing N N 142 
GLN   CA  C    sing N N 143 
GLN   CA  CB   sing N N 144 
GLN   CA  HA   sing N N 145 
GLN   C   O    doub N N 146 
GLN   C   OXT  sing N N 147 
GLN   CB  CG   sing N N 148 
GLN   CB  HB2  sing N N 149 
GLN   CB  HB3  sing N N 150 
GLN   CG  CD   sing N N 151 
GLN   CG  HG2  sing N N 152 
GLN   CG  HG3  sing N N 153 
GLN   CD  OE1  doub N N 154 
GLN   CD  NE2  sing N N 155 
GLN   NE2 HE21 sing N N 156 
GLN   NE2 HE22 sing N N 157 
GLN   OXT HXT  sing N N 158 
GLU   N   CA   sing N N 159 
GLU   N   H    sing N N 160 
GLU   N   H2   sing N N 161 
GLU   CA  C    sing N N 162 
GLU   CA  CB   sing N N 163 
GLU   CA  HA   sing N N 164 
GLU   C   O    doub N N 165 
GLU   C   OXT  sing N N 166 
GLU   CB  CG   sing N N 167 
GLU   CB  HB2  sing N N 168 
GLU   CB  HB3  sing N N 169 
GLU   CG  CD   sing N N 170 
GLU   CG  HG2  sing N N 171 
GLU   CG  HG3  sing N N 172 
GLU   CD  OE1  doub N N 173 
GLU   CD  OE2  sing N N 174 
GLU   OE2 HE2  sing N N 175 
GLU   OXT HXT  sing N N 176 
GLY   N   CA   sing N N 177 
GLY   N   H    sing N N 178 
GLY   N   H2   sing N N 179 
GLY   CA  C    sing N N 180 
GLY   CA  HA2  sing N N 181 
GLY   CA  HA3  sing N N 182 
GLY   C   O    doub N N 183 
GLY   C   OXT  sing N N 184 
GLY   OXT HXT  sing N N 185 
HIS   N   CA   sing N N 186 
HIS   N   H    sing N N 187 
HIS   N   H2   sing N N 188 
HIS   CA  C    sing N N 189 
HIS   CA  CB   sing N N 190 
HIS   CA  HA   sing N N 191 
HIS   C   O    doub N N 192 
HIS   C   OXT  sing N N 193 
HIS   CB  CG   sing N N 194 
HIS   CB  HB2  sing N N 195 
HIS   CB  HB3  sing N N 196 
HIS   CG  ND1  sing Y N 197 
HIS   CG  CD2  doub Y N 198 
HIS   ND1 CE1  doub Y N 199 
HIS   ND1 HD1  sing N N 200 
HIS   CD2 NE2  sing Y N 201 
HIS   CD2 HD2  sing N N 202 
HIS   CE1 NE2  sing Y N 203 
HIS   CE1 HE1  sing N N 204 
HIS   NE2 HE2  sing N N 205 
HIS   OXT HXT  sing N N 206 
HOH   O   H1   sing N N 207 
HOH   O   H2   sing N N 208 
ILE   N   CA   sing N N 209 
ILE   N   H    sing N N 210 
ILE   N   H2   sing N N 211 
ILE   CA  C    sing N N 212 
ILE   CA  CB   sing N N 213 
ILE   CA  HA   sing N N 214 
ILE   C   O    doub N N 215 
ILE   C   OXT  sing N N 216 
ILE   CB  CG1  sing N N 217 
ILE   CB  CG2  sing N N 218 
ILE   CB  HB   sing N N 219 
ILE   CG1 CD1  sing N N 220 
ILE   CG1 HG12 sing N N 221 
ILE   CG1 HG13 sing N N 222 
ILE   CG2 HG21 sing N N 223 
ILE   CG2 HG22 sing N N 224 
ILE   CG2 HG23 sing N N 225 
ILE   CD1 HD11 sing N N 226 
ILE   CD1 HD12 sing N N 227 
ILE   CD1 HD13 sing N N 228 
ILE   OXT HXT  sing N N 229 
LEU   N   CA   sing N N 230 
LEU   N   H    sing N N 231 
LEU   N   H2   sing N N 232 
LEU   CA  C    sing N N 233 
LEU   CA  CB   sing N N 234 
LEU   CA  HA   sing N N 235 
LEU   C   O    doub N N 236 
LEU   C   OXT  sing N N 237 
LEU   CB  CG   sing N N 238 
LEU   CB  HB2  sing N N 239 
LEU   CB  HB3  sing N N 240 
LEU   CG  CD1  sing N N 241 
LEU   CG  CD2  sing N N 242 
LEU   CG  HG   sing N N 243 
LEU   CD1 HD11 sing N N 244 
LEU   CD1 HD12 sing N N 245 
LEU   CD1 HD13 sing N N 246 
LEU   CD2 HD21 sing N N 247 
LEU   CD2 HD22 sing N N 248 
LEU   CD2 HD23 sing N N 249 
LEU   OXT HXT  sing N N 250 
LYS   N   CA   sing N N 251 
LYS   N   H    sing N N 252 
LYS   N   H2   sing N N 253 
LYS   CA  C    sing N N 254 
LYS   CA  CB   sing N N 255 
LYS   CA  HA   sing N N 256 
LYS   C   O    doub N N 257 
LYS   C   OXT  sing N N 258 
LYS   CB  CG   sing N N 259 
LYS   CB  HB2  sing N N 260 
LYS   CB  HB3  sing N N 261 
LYS   CG  CD   sing N N 262 
LYS   CG  HG2  sing N N 263 
LYS   CG  HG3  sing N N 264 
LYS   CD  CE   sing N N 265 
LYS   CD  HD2  sing N N 266 
LYS   CD  HD3  sing N N 267 
LYS   CE  NZ   sing N N 268 
LYS   CE  HE2  sing N N 269 
LYS   CE  HE3  sing N N 270 
LYS   NZ  HZ1  sing N N 271 
LYS   NZ  HZ2  sing N N 272 
LYS   NZ  HZ3  sing N N 273 
LYS   OXT HXT  sing N N 274 
MET   N   CA   sing N N 275 
MET   N   H    sing N N 276 
MET   N   H2   sing N N 277 
MET   CA  C    sing N N 278 
MET   CA  CB   sing N N 279 
MET   CA  HA   sing N N 280 
MET   C   O    doub N N 281 
MET   C   OXT  sing N N 282 
MET   CB  CG   sing N N 283 
MET   CB  HB2  sing N N 284 
MET   CB  HB3  sing N N 285 
MET   CG  SD   sing N N 286 
MET   CG  HG2  sing N N 287 
MET   CG  HG3  sing N N 288 
MET   SD  CE   sing N N 289 
MET   CE  HE1  sing N N 290 
MET   CE  HE2  sing N N 291 
MET   CE  HE3  sing N N 292 
MET   OXT HXT  sing N N 293 
PHE   N   CA   sing N N 294 
PHE   N   H    sing N N 295 
PHE   N   H2   sing N N 296 
PHE   CA  C    sing N N 297 
PHE   CA  CB   sing N N 298 
PHE   CA  HA   sing N N 299 
PHE   C   O    doub N N 300 
PHE   C   OXT  sing N N 301 
PHE   CB  CG   sing N N 302 
PHE   CB  HB2  sing N N 303 
PHE   CB  HB3  sing N N 304 
PHE   CG  CD1  doub Y N 305 
PHE   CG  CD2  sing Y N 306 
PHE   CD1 CE1  sing Y N 307 
PHE   CD1 HD1  sing N N 308 
PHE   CD2 CE2  doub Y N 309 
PHE   CD2 HD2  sing N N 310 
PHE   CE1 CZ   doub Y N 311 
PHE   CE1 HE1  sing N N 312 
PHE   CE2 CZ   sing Y N 313 
PHE   CE2 HE2  sing N N 314 
PHE   CZ  HZ   sing N N 315 
PHE   OXT HXT  sing N N 316 
PRO   N   CA   sing N N 317 
PRO   N   CD   sing N N 318 
PRO   N   H    sing N N 319 
PRO   CA  C    sing N N 320 
PRO   CA  CB   sing N N 321 
PRO   CA  HA   sing N N 322 
PRO   C   O    doub N N 323 
PRO   C   OXT  sing N N 324 
PRO   CB  CG   sing N N 325 
PRO   CB  HB2  sing N N 326 
PRO   CB  HB3  sing N N 327 
PRO   CG  CD   sing N N 328 
PRO   CG  HG2  sing N N 329 
PRO   CG  HG3  sing N N 330 
PRO   CD  HD2  sing N N 331 
PRO   CD  HD3  sing N N 332 
PRO   OXT HXT  sing N N 333 
SER   N   CA   sing N N 334 
SER   N   H    sing N N 335 
SER   N   H2   sing N N 336 
SER   CA  C    sing N N 337 
SER   CA  CB   sing N N 338 
SER   CA  HA   sing N N 339 
SER   C   O    doub N N 340 
SER   C   OXT  sing N N 341 
SER   CB  OG   sing N N 342 
SER   CB  HB2  sing N N 343 
SER   CB  HB3  sing N N 344 
SER   OG  HG   sing N N 345 
SER   OXT HXT  sing N N 346 
THR   N   CA   sing N N 347 
THR   N   H    sing N N 348 
THR   N   H2   sing N N 349 
THR   CA  C    sing N N 350 
THR   CA  CB   sing N N 351 
THR   CA  HA   sing N N 352 
THR   C   O    doub N N 353 
THR   C   OXT  sing N N 354 
THR   CB  OG1  sing N N 355 
THR   CB  CG2  sing N N 356 
THR   CB  HB   sing N N 357 
THR   OG1 HG1  sing N N 358 
THR   CG2 HG21 sing N N 359 
THR   CG2 HG22 sing N N 360 
THR   CG2 HG23 sing N N 361 
THR   OXT HXT  sing N N 362 
TYR   N   CA   sing N N 363 
TYR   N   H    sing N N 364 
TYR   N   H2   sing N N 365 
TYR   CA  C    sing N N 366 
TYR   CA  CB   sing N N 367 
TYR   CA  HA   sing N N 368 
TYR   C   O    doub N N 369 
TYR   C   OXT  sing N N 370 
TYR   CB  CG   sing N N 371 
TYR   CB  HB2  sing N N 372 
TYR   CB  HB3  sing N N 373 
TYR   CG  CD1  doub Y N 374 
TYR   CG  CD2  sing Y N 375 
TYR   CD1 CE1  sing Y N 376 
TYR   CD1 HD1  sing N N 377 
TYR   CD2 CE2  doub Y N 378 
TYR   CD2 HD2  sing N N 379 
TYR   CE1 CZ   doub Y N 380 
TYR   CE1 HE1  sing N N 381 
TYR   CE2 CZ   sing Y N 382 
TYR   CE2 HE2  sing N N 383 
TYR   CZ  OH   sing N N 384 
TYR   OH  HH   sing N N 385 
TYR   OXT HXT  sing N N 386 
VAL   N   CA   sing N N 387 
VAL   N   H    sing N N 388 
VAL   N   H2   sing N N 389 
VAL   CA  C    sing N N 390 
VAL   CA  CB   sing N N 391 
VAL   CA  HA   sing N N 392 
VAL   C   O    doub N N 393 
VAL   C   OXT  sing N N 394 
VAL   CB  CG1  sing N N 395 
VAL   CB  CG2  sing N N 396 
VAL   CB  HB   sing N N 397 
VAL   CG1 HG11 sing N N 398 
VAL   CG1 HG12 sing N N 399 
VAL   CG1 HG13 sing N N 400 
VAL   CG2 HG21 sing N N 401 
VAL   CG2 HG22 sing N N 402 
VAL   CG2 HG23 sing N N 403 
VAL   OXT HXT  sing N N 404 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121054 1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121052 2 
'Japan Society for the Promotion of Science (JSPS)'        Japan 15H02896      3 
'Japan Society for the Promotion of Science (JSPS)'        Japan 16K13044      4 
'Japan Society for the Promotion of Science (JSPS)'        Japan 18H03190      5 
'Japan Society for the Promotion of Science (JSPS)'        Japan 21H03354      6 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6KXY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YT6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021907 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016312 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009935 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP   A 1 6   ? -7.47400  -6.29300  -1.15000  1.000 63.18639 ? 202 ASP   A N   1 
ATOM   2    C CA  . ASP   A 1 6   ? -8.77100  -6.94500  -1.02500  1.000 61.00370 ? 202 ASP   A CA  1 
ATOM   3    C C   . ASP   A 1 6   ? -9.15100  -7.63200  -2.33500  1.000 60.72807 ? 202 ASP   A C   1 
ATOM   4    O O   . ASP   A 1 6   ? -8.96900  -7.07500  -3.41900  1.000 57.87112 ? 202 ASP   A O   1 
ATOM   5    C CB  . ASP   A 1 6   ? -9.83800  -5.93200  -0.59200  1.000 67.96778 ? 202 ASP   A CB  1 
ATOM   6    C CG  . ASP   A 1 6   ? -10.13100 -4.88900  -1.65600  1.000 69.63283 ? 202 ASP   A CG  1 
ATOM   7    O OD1 . ASP   A 1 6   ? -10.86500 -5.19900  -2.61900  1.000 64.33109 ? 202 ASP   A OD1 1 
ATOM   8    O OD2 . ASP   A 1 6   ? -9.61600  -3.75700  -1.53400  1.000 73.56603 ? 202 ASP   A OD2 1 
ATOM   9    N N   . LEU   A 1 7   ? -9.67900  -8.85300  -2.22400  1.000 54.39829 ? 203 LEU   A N   1 
ATOM   10   C CA  . LEU   A 1 7   ? -9.88800  -9.70300  -3.38800  1.000 53.44090 ? 203 LEU   A CA  1 
ATOM   11   C C   . LEU   A 1 7   ? -11.17000 -9.39200  -4.15200  1.000 45.86697 ? 203 LEU   A C   1 
ATOM   12   O O   . LEU   A 1 7   ? -11.31500 -9.85800  -5.28600  1.000 46.34919 ? 203 LEU   A O   1 
ATOM   13   C CB  . LEU   A 1 7   ? -9.89300  -11.17700 -2.97000  1.000 45.06860 ? 203 LEU   A CB  1 
ATOM   14   C CG  . LEU   A 1 7   ? -8.60600  -11.71900 -2.33800  1.000 53.76969 ? 203 LEU   A CG  1 
ATOM   15   C CD1 . LEU   A 1 7   ? -8.65100  -13.23600 -2.22600  1.000 45.58699 ? 203 LEU   A CD1 1 
ATOM   16   C CD2 . LEU   A 1 7   ? -7.37900  -11.27900 -3.11800  1.000 49.42001 ? 203 LEU   A CD2 1 
ATOM   17   N N   . LYS   A 1 8   ? -12.10000 -8.63000  -3.57200  1.000 51.37374 ? 204 LYS   A N   1 
ATOM   18   C CA  . LYS   A 1 8   ? -13.34100 -8.34200  -4.28500  1.000 54.64587 ? 204 LYS   A CA  1 
ATOM   19   C C   . LYS   A 1 8   ? -13.09600 -7.49900  -5.53200  1.000 54.25754 ? 204 LYS   A C   1 
ATOM   20   O O   . LYS   A 1 8   ? -13.80800 -7.65200  -6.53100  1.000 52.86410 ? 204 LYS   A O   1 
ATOM   21   C CB  . LYS   A 1 8   ? -14.34300 -7.64700  -3.36300  1.000 58.68141 ? 204 LYS   A CB  1 
ATOM   22   C CG  . LYS   A 1 8   ? -15.19100 -8.60500  -2.53600  1.000 57.36759 ? 204 LYS   A CG  1 
ATOM   23   C CD  . LYS   A 1 8   ? -16.34300 -7.87900  -1.85400  1.000 65.81280 ? 204 LYS   A CD  1 
ATOM   24   C CE  . LYS   A 1 8   ? -15.85000 -6.81800  -0.88300  1.000 58.33567 ? 204 LYS   A CE  1 
ATOM   25   N NZ  . LYS   A 1 8   ? -16.62100 -6.82600  0.39300   1.000 57.73839 ? 204 LYS   A NZ  1 
ATOM   26   N N   . SER   A 1 9   ? -12.09600 -6.62000  -5.50300  1.000 51.89678 ? 205 SER   A N   1 
ATOM   27   C CA  . SER   A 1 9   ? -11.77700 -5.76900  -6.64200  1.000 50.85156 ? 205 SER   A CA  1 
ATOM   28   C C   . SER   A 1 9   ? -10.48300 -6.17700  -7.33500  1.000 49.45723 ? 205 SER   A C   1 
ATOM   29   O O   . SER   A 1 9   ? -10.01500 -5.45300  -8.22200  1.000 45.21708 ? 205 SER   A O   1 
ATOM   30   C CB  . SER   A 1 9   ? -11.69600 -4.30600  -6.20000  1.000 45.46092 ? 205 SER   A CB  1 
ATOM   31   O OG  . SER   A 1 9   ? -10.79000 -4.15200  -5.12200  1.000 51.74118 ? 205 SER   A OG  1 
ATOM   32   N N   . LEU   A 1 10  ? -9.89800  -7.31800  -6.96000  1.000 43.09514 ? 206 LEU   A N   1 
ATOM   33   C CA  . LEU   A 1 10  ? -8.60400  -7.71300  -7.51300  1.000 44.27003 ? 206 LEU   A CA  1 
ATOM   34   C C   . LEU   A 1 10  ? -8.66600  -7.88500  -9.02700  1.000 33.06898 ? 206 LEU   A C   1 
ATOM   35   O O   . LEU   A 1 10  ? -7.80700  -7.37200  -9.75400  1.000 39.67707 ? 206 LEU   A O   1 
ATOM   36   C CB  . LEU   A 1 10  ? -8.11800  -9.00000  -6.84700  1.000 39.63681 ? 206 LEU   A CB  1 
ATOM   37   C CG  . LEU   A 1 10  ? -6.67300  -9.39700  -7.16700  1.000 37.57435 ? 206 LEU   A CG  1 
ATOM   38   C CD1 . LEU   A 1 10  ? -5.69300  -8.32000  -6.72900  1.000 37.86310 ? 206 LEU   A CD1 1 
ATOM   39   C CD2 . LEU   A 1 10  ? -6.32100  -10.73300 -6.54100  1.000 33.91148 ? 206 LEU   A CD2 1 
ATOM   40   N N   . ALA   A 1 11  ? -9.67100  -8.61500  -9.52100  1.000 36.09801 ? 207 ALA   A N   1 
ATOM   41   C CA  . ALA   A 1 11  ? -9.74200  -8.90700  -10.95100 1.000 33.54408 ? 207 ALA   A CA  1 
ATOM   42   C C   . ALA   A 1 11  ? -9.85600  -7.63100  -11.77200 1.000 37.93253 ? 207 ALA   A C   1 
ATOM   43   O O   . ALA   A 1 11  ? -9.16000  -7.46300  -12.78000 1.000 30.48439 ? 207 ALA   A O   1 
ATOM   44   C CB  . ALA   A 1 11  ? -10.92100 -9.83100  -11.24700 1.000 31.45748 ? 207 ALA   A CB  1 
ATOM   45   N N   . LYS   A 1 12  ? -10.74300 -6.72200  -11.35900 1.000 41.78167 ? 208 LYS   A N   1 
ATOM   46   C CA  . LYS   A 1 12  ? -10.87800 -5.44700  -12.05700 1.000 41.89544 ? 208 LYS   A CA  1 
ATOM   47   C C   . LYS   A 1 12  ? -9.60200  -4.62300  -11.95400 1.000 31.50761 ? 208 LYS   A C   1 
ATOM   48   O O   . LYS   A 1 12  ? -9.18400  -3.99100  -12.93000 1.000 33.74945 ? 208 LYS   A O   1 
ATOM   49   C CB  . LYS   A 1 12  ? -12.06800 -4.66400  -11.49400 1.000 44.56457 ? 208 LYS   A CB  1 
ATOM   50   C CG  . LYS   A 1 12  ? -12.25700 -3.25900  -12.08100 1.000 46.27310 ? 208 LYS   A CG  1 
ATOM   51   C CD  . LYS   A 1 12  ? -12.77700 -3.23900  -13.52400 1.000 56.41513 ? 208 LYS   A CD  1 
ATOM   52   C CE  . LYS   A 1 12  ? -13.65600 -4.43800  -13.86300 1.000 60.97559 ? 208 LYS   A CE  1 
ATOM   53   N NZ  . LYS   A 1 12  ? -14.07800 -4.42000  -15.29300 1.000 67.48170 ? 208 LYS   A NZ  1 
ATOM   54   N N   . ARG   A 1 13  ? -8.96700  -4.61800  -10.77800 1.000 33.29638 ? 209 ARG   A N   1 
ATOM   55   C CA  . ARG   A 1 13  ? -7.76200  -3.81500  -10.59100 1.000 34.82599 ? 209 ARG   A CA  1 
ATOM   56   C C   . ARG   A 1 13  ? -6.62600  -4.30900  -11.47800 1.000 28.63131 ? 209 ARG   A C   1 
ATOM   57   O O   . ARG   A 1 13  ? -5.90400  -3.50700  -12.08400 1.000 28.09546 ? 209 ARG   A O   1 
ATOM   58   C CB  . ARG   A 1 13  ? -7.33600  -3.84000  -9.12300  1.000 40.56873 ? 209 ARG   A CB  1 
ATOM   59   C CG  . ARG   A 1 13  ? -8.01400  -2.79700  -8.24000  1.000 48.80323 ? 209 ARG   A CG  1 
ATOM   60   C CD  . ARG   A 1 13  ? -7.33000  -2.72000  -6.88200  1.000 56.72559 ? 209 ARG   A CD  1 
ATOM   61   N NE  . ARG   A 1 13  ? -7.75500  -3.80000  -5.99900  1.000 58.96907 ? 209 ARG   A NE  1 
ATOM   62   C CZ  . ARG   A 1 13  ? -7.28300  -3.99800  -4.77600  1.000 65.58809 ? 209 ARG   A CZ  1 
ATOM   63   N NH1 . ARG   A 1 13  ? -6.35600  -3.20900  -4.25500  1.000 59.91351 ? 209 ARG   A NH1 1 
ATOM   64   N NH2 . ARG   A 1 13  ? -7.74800  -5.01700  -4.05800  1.000 65.70171 ? 209 ARG   A NH2 1 
ATOM   65   N N   . ILE   A 1 14  ? -6.45100  -5.62700  -11.56500 1.000 26.12808 ? 210 ILE   A N   1 
ATOM   66   C CA  . ILE   A 1 14  ? -5.39300  -6.17500  -12.40700 1.000 24.71979 ? 210 ILE   A CA  1 
ATOM   67   C C   . ILE   A 1 14  ? -5.70600  -5.93700  -13.88000 1.000 22.27306 ? 210 ILE   A C   1 
ATOM   68   O O   . ILE   A 1 14  ? -4.81800  -5.59600  -14.67200 1.000 25.75430 ? 210 ILE   A O   1 
ATOM   69   C CB  . ILE   A 1 14  ? -5.19100  -7.66800  -12.08800 1.000 24.95950 ? 210 ILE   A CB  1 
ATOM   70   C CG1 . ILE   A 1 14  ? -4.44400  -7.82100  -10.76100 1.000 22.18979 ? 210 ILE   A CG1 1 
ATOM   71   C CG2 . ILE   A 1 14  ? -4.44200  -8.37400  -13.20700 1.000 25.84499 ? 210 ILE   A CG2 1 
ATOM   72   C CD1 . ILE   A 1 14  ? -4.54800  -9.20100  -10.14800 1.000 31.96803 ? 210 ILE   A CD1 1 
ATOM   73   N N   . TYR   A 1 15  ? -6.97400  -6.09200  -14.26700 1.000 25.20764 ? 211 TYR   A N   1 
ATOM   74   C CA  . TYR   A 1 15  ? -7.36500  -5.82800  -15.64700 1.000 25.87076 ? 211 TYR   A CA  1 
ATOM   75   C C   . TYR   A 1 15  ? -7.13500  -4.36600  -16.01200 1.000 30.12686 ? 211 TYR   A C   1 
ATOM   76   O O   . TYR   A 1 15  ? -6.61800  -4.06000  -17.09300 1.000 29.72716 ? 211 TYR   A O   1 
ATOM   77   C CB  . TYR   A 1 15  ? -8.83000  -6.21900  -15.85000 1.000 26.78250 ? 211 TYR   A CB  1 
ATOM   78   C CG  . TYR   A 1 15  ? -9.33900  -6.09000  -17.27000 1.000 30.15715 ? 211 TYR   A CG  1 
ATOM   79   C CD1 . TYR   A 1 15  ? -8.50600  -6.31000  -18.35800 1.000 28.68773 ? 211 TYR   A CD1 1 
ATOM   80   C CD2 . TYR   A 1 15  ? -10.66400 -5.75700  -17.51800 1.000 35.36016 ? 211 TYR   A CD2 1 
ATOM   81   C CE1 . TYR   A 1 15  ? -8.98000  -6.19500  -19.65600 1.000 28.99963 ? 211 TYR   A CE1 1 
ATOM   82   C CE2 . TYR   A 1 15  ? -11.14300 -5.64100  -18.80700 1.000 39.52250 ? 211 TYR   A CE2 1 
ATOM   83   C CZ  . TYR   A 1 15  ? -10.29900 -5.86000  -19.87200 1.000 37.19203 ? 211 TYR   A CZ  1 
ATOM   84   O OH  . TYR   A 1 15  ? -10.78300 -5.74600  -21.15700 1.000 36.87762 ? 211 TYR   A OH  1 
ATOM   85   N N   . GLU   A 1 16  ? -7.50300  -3.44600  -15.11700 1.000 30.61310 ? 212 GLU   A N   1 
ATOM   86   C CA  . GLU   A 1 16  ? -7.26700  -2.03200  -15.38600 1.000 30.92783 ? 212 GLU   A CA  1 
ATOM   87   C C   . GLU   A 1 16  ? -5.77700  -1.73100  -15.51400 1.000 26.45347 ? 212 GLU   A C   1 
ATOM   88   O O   . GLU   A 1 16  ? -5.36400  -1.00000  -16.42000 1.000 27.42106 ? 212 GLU   A O   1 
ATOM   89   C CB  . GLU   A 1 16  ? -7.91200  -1.17800  -14.29500 1.000 32.72367 ? 212 GLU   A CB  1 
ATOM   90   C CG  . GLU   A 1 16  ? -9.41800  -1.03100  -14.47500 1.000 43.91305 ? 212 GLU   A CG  1 
ATOM   91   C CD  . GLU   A 1 16  ? -10.09500 -0.34400  -13.30400 1.000 48.90958 ? 212 GLU   A CD  1 
ATOM   92   O OE1 . GLU   A 1 16  ? -9.39000  0.07200   -12.36000 1.000 44.47548 ? 212 GLU   A OE1 1 
ATOM   93   O OE2 . GLU   A 1 16  ? -11.33800 -0.22400  -13.32900 1.000 51.35246 ? 212 GLU   A OE2 1 
ATOM   94   N N   . ALA   A 1 17  ? -4.95200  -2.30400  -14.63200 1.000 24.95432 ? 213 ALA   A N   1 
ATOM   95   C CA  . ALA   A 1 17  ? -3.50600  -2.10200  -14.72000 1.000 27.71997 ? 213 ALA   A CA  1 
ATOM   96   C C   . ALA   A 1 17  ? -2.93100  -2.66500  -16.01500 1.000 28.76051 ? 213 ALA   A C   1 
ATOM   97   O O   . ALA   A 1 17  ? -1.94000  -2.14000  -16.53800 1.000 27.20726 ? 213 ALA   A O   1 
ATOM   98   C CB  . ALA   A 1 17  ? -2.81500  -2.75000  -13.52200 1.000 27.77833 ? 213 ALA   A CB  1 
ATOM   99   N N   . TYR   A 1 18  ? -3.52300  -3.74400  -16.52700 1.000 24.54620 ? 214 TYR   A N   1 
ATOM   100  C CA  . TYR   A 1 18  ? -3.09600  -4.32000  -17.79900 1.000 23.18247 ? 214 TYR   A CA  1 
ATOM   101  C C   . TYR   A 1 18  ? -3.44000  -3.39300  -18.95900 1.000 30.98413 ? 214 TYR   A C   1 
ATOM   102  O O   . TYR   A 1 18  ? -2.59600  -3.11300  -19.82000 1.000 27.54055 ? 214 TYR   A O   1 
ATOM   103  C CB  . TYR   A 1 18  ? -3.75400  -5.69100  -17.95300 1.000 22.08405 ? 214 TYR   A CB  1 
ATOM   104  C CG  . TYR   A 1 18  ? -3.62500  -6.40200  -19.28300 1.000 25.29152 ? 214 TYR   A CG  1 
ATOM   105  C CD1 . TYR   A 1 18  ? -2.65600  -7.37900  -19.48500 1.000 26.45076 ? 214 TYR   A CD1 1 
ATOM   106  C CD2 . TYR   A 1 18  ? -4.52800  -6.15300  -20.30900 1.000 33.59781 ? 214 TYR   A CD2 1 
ATOM   107  C CE1 . TYR   A 1 18  ? -2.56700  -8.05500  -20.69200 1.000 26.17957 ? 214 TYR   A CE1 1 
ATOM   108  C CE2 . TYR   A 1 18  ? -4.45000  -6.81700  -21.50800 1.000 36.77062 ? 214 TYR   A CE2 1 
ATOM   109  C CZ  . TYR   A 1 18  ? -3.47100  -7.76400  -21.70000 1.000 31.54273 ? 214 TYR   A CZ  1 
ATOM   110  O OH  . TYR   A 1 18  ? -3.41100  -8.42000  -22.90600 1.000 39.80338 ? 214 TYR   A OH  1 
ATOM   111  N N   . LEU   A 1 19  ? -4.67700  -2.89900  -18.99600 1.000 24.70328 ? 215 LEU   A N   1 
ATOM   112  C CA  . LEU   A 1 19  ? -5.04600  -1.94000  -20.03000 1.000 26.92808 ? 215 LEU   A CA  1 
ATOM   113  C C   . LEU   A 1 19  ? -4.23700  -0.65500  -19.91800 1.000 28.42232 ? 215 LEU   A C   1 
ATOM   114  O O   . LEU   A 1 19  ? -3.93500  -0.02200  -20.93600 1.000 33.87142 ? 215 LEU   A O   1 
ATOM   115  C CB  . LEU   A 1 19  ? -6.54200  -1.64200  -19.95300 1.000 27.08123 ? 215 LEU   A CB  1 
ATOM   116  C CG  . LEU   A 1 19  ? -7.47200  -2.83900  -20.13400 1.000 33.35192 ? 215 LEU   A CG  1 
ATOM   117  C CD1 . LEU   A 1 19  ? -8.91800  -2.44000  -19.89200 1.000 41.51689 ? 215 LEU   A CD1 1 
ATOM   118  C CD2 . LEU   A 1 19  ? -7.30500  -3.41600  -21.53000 1.000 37.11377 ? 215 LEU   A CD2 1 
ATOM   119  N N   . LYS   A 1 20  ? -3.85500  -0.26600  -18.69800 1.000 29.65461 ? 216 LYS   A N   1 
ATOM   120  C CA  . LYS   A 1 20  ? -3.13700  0.99100   -18.50900 1.000 27.13830 ? 216 LYS   A CA  1 
ATOM   121  C C   . LYS   A 1 20  ? -1.69900  0.91300   -19.00100 1.000 36.08943 ? 216 LYS   A C   1 
ATOM   122  O O   . LYS   A 1 20  ? -1.15200  1.91800   -19.46600 1.000 34.01854 ? 216 LYS   A O   1 
ATOM   123  C CB  . LYS   A 1 20  ? -3.13300  1.38900   -17.03200 1.000 32.40304 ? 216 LYS   A CB  1 
ATOM   124  C CG  . LYS   A 1 20  ? -4.40600  2.04700   -16.53300 1.000 43.98393 ? 216 LYS   A CG  1 
ATOM   125  C CD  . LYS   A 1 20  ? -4.25000  2.47800   -15.08000 1.000 42.58647 ? 216 LYS   A CD  1 
ATOM   126  C CE  . LYS   A 1 20  ? -5.57300  2.94700   -14.49500 1.000 47.96878 ? 216 LYS   A CE  1 
ATOM   127  N NZ  . LYS   A 1 20  ? -5.48300  4.34800   -13.99000 1.000 53.21102 ? 216 LYS   A NZ  1 
ATOM   128  N N   . ASN   A 1 21  ? -1.06100  -0.25200  -18.88900 1.000 23.31978 ? 217 ASN   A N   1 
ATOM   129  C CA  . ASN   A 1 21  ? 0.38800   -0.31200  -18.99700 1.000 27.07309 ? 217 ASN   A CA  1 
ATOM   130  C C   . ASN   A 1 21  ? 0.91800   -0.93600  -20.28000 1.000 26.38264 ? 217 ASN   A C   1 
ATOM   131  O O   . ASN   A 1 21  ? 2.07100   -0.67300  -20.62900 1.000 28.34991 ? 217 ASN   A O   1 
ATOM   132  C CB  . ASN   A 1 21  ? 0.97400   -1.06500  -17.79400 1.000 28.24759 ? 217 ASN   A CB  1 
ATOM   133  C CG  . ASN   A 1 21  ? 1.06600   -0.19100  -16.55800 1.000 30.60897 ? 217 ASN   A CG  1 
ATOM   134  O OD1 . ASN   A 1 21  ? 1.87600   0.72900   -16.50600 1.000 33.75731 ? 217 ASN   A OD1 1 
ATOM   135  N ND2 . ASN   A 1 21  ? 0.23100   -0.46900  -15.56000 1.000 27.31082 ? 217 ASN   A ND2 1 
ATOM   136  N N   . PHE   A 1 22  ? 0.13500   -1.74200  -20.99100 1.000 29.13061 ? 218 PHE   A N   1 
ATOM   137  C CA  . PHE   A 1 22  ? 0.62200   -2.42000  -22.18700 1.000 26.93731 ? 218 PHE   A CA  1 
ATOM   138  C C   . PHE   A 1 22  ? 0.13400   -1.69400  -23.43200 1.000 33.70016 ? 218 PHE   A C   1 
ATOM   139  O O   . PHE   A 1 22  ? -1.07600  -1.53600  -23.63200 1.000 28.31328 ? 218 PHE   A O   1 
ATOM   140  C CB  . PHE   A 1 22  ? 0.19200   -3.88700  -22.19700 1.000 29.65410 ? 218 PHE   A CB  1 
ATOM   141  C CG  . PHE   A 1 22  ? 0.76600   -4.67600  -21.06100 1.000 24.48130 ? 218 PHE   A CG  1 
ATOM   142  C CD1 . PHE   A 1 22  ? 2.13700   -4.83900  -20.93900 1.000 29.23449 ? 218 PHE   A CD1 1 
ATOM   143  C CD2 . PHE   A 1 22  ? -0.05600  -5.22200  -20.09400 1.000 24.12580 ? 218 PHE   A CD2 1 
ATOM   144  C CE1 . PHE   A 1 22  ? 2.67500   -5.55200  -19.88200 1.000 23.36205 ? 218 PHE   A CE1 1 
ATOM   145  C CE2 . PHE   A 1 22  ? 0.47500   -5.93200  -19.03800 1.000 21.26560 ? 218 PHE   A CE2 1 
ATOM   146  C CZ  . PHE   A 1 22  ? 1.84000   -6.09700  -18.93000 1.000 25.36618 ? 218 PHE   A CZ  1 
ATOM   147  N N   . ASN   A 1 23  ? 1.08500   -1.25900  -24.26700 1.000 35.63382 ? 219 ASN   A N   1 
ATOM   148  C CA  . ASN   A 1 23  ? 0.74400   -0.53200  -25.48500 1.000 35.59151 ? 219 ASN   A CA  1 
ATOM   149  C C   . ASN   A 1 23  ? -0.10600  -1.37700  -26.42000 1.000 30.78012 ? 219 ASN   A C   1 
ATOM   150  O O   . ASN   A 1 23  ? -0.93600  -0.84100  -27.16400 1.000 31.07842 ? 219 ASN   A O   1 
ATOM   151  C CB  . ASN   A 1 23  ? 2.02100   -0.06000  -26.19100 1.000 37.47321 ? 219 ASN   A CB  1 
ATOM   152  C CG  . ASN   A 1 23  ? 2.71800   -1.17300  -26.98000 1.000 36.83829 ? 219 ASN   A CG  1 
ATOM   153  O OD1 . ASN   A 1 23  ? 2.35700   -1.46700  -28.12200 1.000 36.85092 ? 219 ASN   A OD1 1 
ATOM   154  N ND2 . ASN   A 1 23  ? 3.72600   -1.78600  -26.37200 1.000 37.71824 ? 219 ASN   A ND2 1 
ATOM   155  N N   . MET   A 1 24  ? 0.06400   -2.68900  -26.38600 1.000 33.67613 ? 220 MET   A N   1 
ATOM   156  C CA  . MET   A 1 24  ? -0.68100  -3.55600  -27.27700 1.000 37.94262 ? 220 MET   A CA  1 
ATOM   157  C C   . MET   A 1 24  ? -1.36800  -4.63100  -26.45100 1.000 36.14439 ? 220 MET   A C   1 
ATOM   158  O O   . MET   A 1 24  ? -0.78500  -5.17400  -25.50600 1.000 35.30144 ? 220 MET   A O   1 
ATOM   159  C CB  . MET   A 1 24  ? 0.23400   -4.18600  -28.32800 1.000 34.74179 ? 220 MET   A CB  1 
ATOM   160  C CG  . MET   A 1 24  ? -0.45100  -5.25100  -29.13600 1.000 38.91612 ? 220 MET   A CG  1 
ATOM   161  S SD  . MET   A 1 24  ? -1.49100  -4.46000  -30.38600 1.000 36.62870 ? 220 MET   A SD  1 
ATOM   162  C CE  . MET   A 1 24  ? -0.49800  -3.02900  -30.82700 1.000 39.49757 ? 220 MET   A CE  1 
ATOM   163  N N   . ASN   A 1 25  ? -2.61900  -4.91100  -26.79400 1.000 32.51815 ? 221 ASN   A N   1 
ATOM   164  C CA  . ASN   A 1 25  ? -3.36600  -5.97900  -26.14700 1.000 35.82715 ? 221 ASN   A CA  1 
ATOM   165  C C   . ASN   A 1 25  ? -4.10200  -6.78300  -27.20900 1.000 34.66851 ? 221 ASN   A C   1 
ATOM   166  O O   . ASN   A 1 25  ? -3.91900  -6.54300  -28.40800 1.000 35.12581 ? 221 ASN   A O   1 
ATOM   167  C CB  . ASN   A 1 25  ? -4.33100  -5.41000  -25.10600 1.000 31.85948 ? 221 ASN   A CB  1 
ATOM   168  C CG  . ASN   A 1 25  ? -5.22000  -4.31300  -25.66300 1.000 36.47007 ? 221 ASN   A CG  1 
ATOM   169  O OD1 . ASN   A 1 25  ? -5.77000  -4.43000  -26.75900 1.000 39.37258 ? 221 ASN   A OD1 1 
ATOM   170  N ND2 . ASN   A 1 25  ? -5.37200  -3.23900  -24.90000 1.000 33.34920 ? 221 ASN   A ND2 1 
ATOM   171  N N   . LYS   A 1 26  ? -4.94900  -7.72400  -26.79200 1.000 32.13133 ? 222 LYS   A N   1 
ATOM   172  C CA  . LYS   A 1 26  ? -5.57600  -8.60300  -27.77300 1.000 34.11574 ? 222 LYS   A CA  1 
ATOM   173  C C   . LYS   A 1 26  ? -6.64300  -7.87600  -28.58000 1.000 35.47700 ? 222 LYS   A C   1 
ATOM   174  O O   . LYS   A 1 26  ? -6.73700  -8.06900  -29.79700 1.000 35.42398 ? 222 LYS   A O   1 
ATOM   175  C CB  . LYS   A 1 26  ? -6.16300  -9.83600  -27.08900 1.000 29.21603 ? 222 LYS   A CB  1 
ATOM   176  C CG  . LYS   A 1 26  ? -6.22100  -11.04700 -28.00200 1.000 30.80263 ? 222 LYS   A CG  1 
ATOM   177  C CD  . LYS   A 1 26  ? -6.26200  -12.33800 -27.21000 1.000 31.16085 ? 222 LYS   A CD  1 
ATOM   178  C CE  . LYS   A 1 26  ? -6.68300  -13.49800 -28.08900 1.000 37.47646 ? 222 LYS   A CE  1 
ATOM   179  N NZ  . LYS   A 1 26  ? -6.65100  -14.78900 -27.35400 1.000 33.51929 ? 222 LYS   A NZ  1 
ATOM   180  N N   . VAL   A 1 27  ? -7.45400  -7.03700  -27.93000 1.000 32.39609 ? 223 VAL   A N   1 
ATOM   181  C CA  . VAL   A 1 27  ? -8.49000  -6.30300  -28.65600 1.000 40.72930 ? 223 VAL   A CA  1 
ATOM   182  C C   . VAL   A 1 27  ? -7.86100  -5.39700  -29.70900 1.000 39.79080 ? 223 VAL   A C   1 
ATOM   183  O O   . VAL   A 1 27  ? -8.30700  -5.35100  -30.86200 1.000 41.35161 ? 223 VAL   A O   1 
ATOM   184  C CB  . VAL   A 1 27  ? -9.37200  -5.50600  -27.67700 1.000 39.57459 ? 223 VAL   A CB  1 
ATOM   185  C CG1 . VAL   A 1 27  ? -9.94700  -4.27300  -28.36200 1.000 47.63318 ? 223 VAL   A CG1 1 
ATOM   186  C CG2 . VAL   A 1 27  ? -10.48700 -6.38700  -27.14100 1.000 47.62289 ? 223 VAL   A CG2 1 
ATOM   187  N N   . LYS   A 1 28  ? -6.81200  -4.66400  -29.32700 1.000 37.63408 ? 224 LYS   A N   1 
ATOM   188  C CA  . LYS   A 1 28  ? -6.13400  -3.79400  -30.28300 1.000 37.43941 ? 224 LYS   A CA  1 
ATOM   189  C C   . LYS   A 1 28  ? -5.50200  -4.60200  -31.41300 1.000 40.33175 ? 224 LYS   A C   1 
ATOM   190  O O   . LYS   A 1 28  ? -5.52700  -4.18300  -32.57600 1.000 40.39558 ? 224 LYS   A O   1 
ATOM   191  C CB  . LYS   A 1 28  ? -5.07900  -2.95100  -29.56700 1.000 38.07517 ? 224 LYS   A CB  1 
ATOM   192  C CG  . LYS   A 1 28  ? -5.61500  -1.65500  -28.97500 1.000 39.92452 ? 224 LYS   A CG  1 
ATOM   193  C CD  . LYS   A 1 28  ? -4.65700  -1.06400  -27.94700 1.000 41.73693 ? 224 LYS   A CD  1 
ATOM   194  C CE  . LYS   A 1 28  ? -4.16900  0.30700   -28.37800 1.000 39.30375 ? 224 LYS   A CE  1 
ATOM   195  N NZ  . LYS   A 1 28  ? -3.21300  0.91200   -27.40600 1.000 33.33780 ? 224 LYS   A NZ  1 
ATOM   196  N N   . ALA   A 1 29  ? -4.94800  -5.77300  -31.09100 1.000 31.55545 ? 225 ALA   A N   1 
ATOM   197  C CA  . ALA   A 1 29  ? -4.23000  -6.55400  -32.09300 1.000 31.89961 ? 225 ALA   A CA  1 
ATOM   198  C C   . ALA   A 1 29  ? -5.17900  -7.17600  -33.11000 1.000 43.40766 ? 225 ALA   A C   1 
ATOM   199  O O   . ALA   A 1 29  ? -4.89500  -7.17100  -34.31400 1.000 42.77528 ? 225 ALA   A O   1 
ATOM   200  C CB  . ALA   A 1 29  ? -3.39500  -7.64000  -31.41700 1.000 34.05103 ? 225 ALA   A CB  1 
ATOM   201  N N   . ARG   A 1 30  ? -6.26200  -7.74200  -32.63600 1.000 39.81934 ? 226 ARG   A N   1 
ATOM   202  C CA  . ARG   A 1 30  ? -7.22600  -8.36400  -33.52000 1.000 47.19946 ? 226 ARG   A CA  1 
ATOM   203  C C   . ARG   A 1 30  ? -7.85400  -7.34800  -34.48000 1.000 42.03675 ? 226 ARG   A C   1 
ATOM   204  O O   . ARG   A 1 30  ? -8.09500  -7.64800  -35.59600 1.000 49.01487 ? 226 ARG   A O   1 
ATOM   205  C CB  . ARG   A 1 30  ? -8.23000  -9.16800  -32.72000 1.000 41.63491 ? 226 ARG   A CB  1 
ATOM   206  C CG  . ARG   A 1 30  ? -7.59000  -10.25800 -31.86900 1.000 51.70381 ? 226 ARG   A CG  1 
ATOM   207  C CD  . ARG   A 1 30  ? -6.95000  -11.39600 -32.67700 1.000 62.88303 ? 226 ARG   A CD  1 
ATOM   208  N NE  . ARG   A 1 30  ? -5.90700  -12.08300 -31.93700 1.000 62.79803 ? 226 ARG   A NE  1 
ATOM   209  C CZ  . ARG   A 1 30  ? -4.99700  -12.91900 -32.44600 1.000 64.11501 ? 226 ARG   A CZ  1 
ATOM   210  N NH1 . ARG   A 1 30  ? -4.95400  -13.22500 -33.71900 1.000 54.89143 ? 226 ARG   A NH1 1 
ATOM   211  N NH2 . ARG   A 1 30  ? -4.12500  -13.46400 -31.64900 1.000 50.69501 ? 226 ARG   A NH2 1 
ATOM   212  N N   . VAL   A 1 31  ? -8.09300  -6.13700  -34.03500 1.000 44.10363 ? 227 VAL   A N   1 
ATOM   213  C CA  . VAL   A 1 31  ? -8.60600  -5.08500  -34.91200 1.000 49.31347 ? 227 VAL   A CA  1 
ATOM   214  C C   . VAL   A 1 31  ? -7.64100  -4.84400  -36.06700 1.000 53.05818 ? 227 VAL   A C   1 
ATOM   215  O O   . VAL   A 1 31  ? -8.04600  -4.75600  -37.23200 1.000 54.23970 ? 227 VAL   A O   1 
ATOM   216  C CB  . VAL   A 1 31  ? -8.86300  -3.79300  -34.11600 1.000 51.69321 ? 227 VAL   A CB  1 
ATOM   217  C CG1 . VAL   A 1 31  ? -9.12600  -2.63300  -35.06200 1.000 51.94663 ? 227 VAL   A CG1 1 
ATOM   218  C CG2 . VAL   A 1 31  ? -10.03900 -3.97700  -33.17200 1.000 49.28251 ? 227 VAL   A CG2 1 
ATOM   219  N N   . ILE   A 1 32  ? -6.34700  -4.74000  -35.75800 1.000 43.44004 ? 228 ILE   A N   1 
ATOM   220  C CA  . ILE   A 1 32  ? -5.34200  -4.55200  -36.80100 1.000 46.55652 ? 228 ILE   A CA  1 
ATOM   221  C C   . ILE   A 1 32  ? -5.25100  -5.79400  -37.67900 1.000 48.47170 ? 228 ILE   A C   1 
ATOM   222  O O   . ILE   A 1 32  ? -5.29300  -5.70800  -38.91200 1.000 55.81748 ? 228 ILE   A O   1 
ATOM   223  C CB  . ILE   A 1 32  ? -3.97900  -4.20700  -36.17400 1.000 38.10466 ? 228 ILE   A CB  1 
ATOM   224  C CG1 . ILE   A 1 32  ? -4.04300  -2.85900  -35.45900 1.000 38.59498 ? 228 ILE   A CG1 1 
ATOM   225  C CG2 . ILE   A 1 32  ? -2.88800  -4.19600  -37.23500 1.000 42.40058 ? 228 ILE   A CG2 1 
ATOM   226  C CD1 . ILE   A 1 32  ? -2.81000  -2.56000  -34.62400 1.000 46.05223 ? 228 ILE   A CD1 1 
ATOM   227  N N   . LEU   A 1 33  ? -5.13500  -6.97000  -37.05500 1.000 49.02866 ? 229 LEU   A N   1 
ATOM   228  C CA  . LEU   A 1 33  ? -5.01700  -8.22800  -37.78400 1.000 43.18934 ? 229 LEU   A CA  1 
ATOM   229  C C   . LEU   A 1 33  ? -6.24900  -8.54400  -38.62100 1.000 52.87375 ? 229 LEU   A C   1 
ATOM   230  O O   . LEU   A 1 33  ? -6.18000  -9.42600  -39.48400 1.000 60.36446 ? 229 LEU   A O   1 
ATOM   231  C CB  . LEU   A 1 33  ? -4.75300  -9.37100  -36.80200 1.000 46.28950 ? 229 LEU   A CB  1 
ATOM   232  C CG  . LEU   A 1 33  ? -3.34600  -9.45400  -36.20900 1.000 48.15452 ? 229 LEU   A CG  1 
ATOM   233  C CD1 . LEU   A 1 33  ? -3.32800  -10.35800 -34.98400 1.000 44.05442 ? 229 LEU   A CD1 1 
ATOM   234  C CD2 . LEU   A 1 33  ? -2.34800  -9.94000  -37.24400 1.000 44.32954 ? 229 LEU   A CD2 1 
ATOM   235  N N   . SER   A 1 34  ? -7.36200  -7.85400  -38.39200 1.000 51.61368 ? 230 SER   A N   1 
ATOM   236  C CA  . SER   A 1 34  ? -8.57200  -8.05300  -39.17700 1.000 58.61163 ? 230 SER   A CA  1 
ATOM   237  C C   . SER   A 1 34  ? -8.66600  -7.04400  -40.31500 1.000 58.94347 ? 230 SER   A C   1 
ATOM   238  O O   . SER   A 1 34  ? -9.72700  -6.87800  -40.91800 1.000 69.33627 ? 230 SER   A O   1 
ATOM   239  C CB  . SER   A 1 34  ? -9.81000  -7.95000  -38.28600 1.000 57.83337 ? 230 SER   A CB  1 
ATOM   240  O OG  . SER   A 1 34  ? -10.33300 -6.63300  -38.29800 1.000 57.44035 ? 230 SER   A OG  1 
ATOM   241  N N   . PRO   A 1 42  ? -1.23400  -2.16800  -41.87100 1.000 53.70953 ? 238 PRO   A N   1 
ATOM   242  C CA  . PRO   A 1 42  ? 0.00800   -2.82800  -41.47200 1.000 52.57324 ? 238 PRO   A CA  1 
ATOM   243  C C   . PRO   A 1 42  ? 0.84600   -3.33900  -42.64200 1.000 48.39618 ? 238 PRO   A C   1 
ATOM   244  O O   . PRO   A 1 42  ? 0.39200   -4.18200  -43.41900 1.000 44.12976 ? 238 PRO   A O   1 
ATOM   245  C CB  . PRO   A 1 42  ? -0.50400  -3.99100  -40.61500 1.000 48.13240 ? 238 PRO   A CB  1 
ATOM   246  C CG  . PRO   A 1 42  ? -1.97100  -4.23900  -41.12700 1.000 48.89372 ? 238 PRO   A CG  1 
ATOM   247  C CD  . PRO   A 1 42  ? -2.23100  -3.19600  -42.20500 1.000 53.33194 ? 238 PRO   A CD  1 
ATOM   248  N N   . PHE   A 1 43  ? 2.06900   -2.82900  -42.75300 1.000 45.49957 ? 239 PHE   A N   1 
ATOM   249  C CA  . PHE   A 1 43  ? 2.95700   -3.25200  -43.82400 1.000 50.59131 ? 239 PHE   A CA  1 
ATOM   250  C C   . PHE   A 1 43  ? 3.35800   -4.71000  -43.62200 1.000 42.45042 ? 239 PHE   A C   1 
ATOM   251  O O   . PHE   A 1 43  ? 3.79800   -5.10000  -42.53600 1.000 39.94102 ? 239 PHE   A O   1 
ATOM   252  C CB  . PHE   A 1 43  ? 4.20000   -2.36700  -43.86900 1.000 44.87675 ? 239 PHE   A CB  1 
ATOM   253  C CG  . PHE   A 1 43  ? 5.13000   -2.70300  -44.99500 1.000 53.26643 ? 239 PHE   A CG  1 
ATOM   254  C CD1 . PHE   A 1 43  ? 4.98600   -2.09700  -46.23000 1.000 62.24628 ? 239 PHE   A CD1 1 
ATOM   255  C CD2 . PHE   A 1 43  ? 6.11800   -3.65700  -44.83500 1.000 53.13375 ? 239 PHE   A CD2 1 
ATOM   256  C CE1 . PHE   A 1 43  ? 5.83000   -2.41300  -47.28000 1.000 59.58309 ? 239 PHE   A CE1 1 
ATOM   257  C CE2 . PHE   A 1 43  ? 6.95700   -3.98000  -45.88000 1.000 52.66411 ? 239 PHE   A CE2 1 
ATOM   258  C CZ  . PHE   A 1 43  ? 6.81600   -3.35600  -47.10100 1.000 57.50091 ? 239 PHE   A CZ  1 
ATOM   259  N N   . VAL   A 1 44  ? 3.22300   -5.51000  -44.67400 1.000 44.94121 ? 240 VAL   A N   1 
ATOM   260  C CA  . VAL   A 1 44  ? 3.51800   -6.93800  -44.61300 1.000 40.29356 ? 240 VAL   A CA  1 
ATOM   261  C C   . VAL   A 1 44  ? 4.97300   -7.15900  -45.00600 1.000 40.79535 ? 240 VAL   A C   1 
ATOM   262  O O   . VAL   A 1 44  ? 5.39200   -6.79200  -46.10900 1.000 47.85795 ? 240 VAL   A O   1 
ATOM   263  C CB  . VAL   A 1 44  ? 2.57400   -7.73900  -45.52100 1.000 45.64993 ? 240 VAL   A CB  1 
ATOM   264  C CG1 . VAL   A 1 44  ? 2.89800   -9.22500  -45.44700 1.000 35.64928 ? 240 VAL   A CG1 1 
ATOM   265  C CG2 . VAL   A 1 44  ? 1.12500   -7.48500  -45.12900 1.000 34.98352 ? 240 VAL   A CG2 1 
ATOM   266  N N   . ILE   A 1 45  ? 5.74200   -7.75800  -44.10400 1.000 33.83779 ? 241 ILE   A N   1 
ATOM   267  C CA  . ILE   A 1 45  ? 7.13800   -8.10100  -44.34500 1.000 36.89078 ? 241 ILE   A CA  1 
ATOM   268  C C   . ILE   A 1 45  ? 7.19100   -9.58900  -44.66100 1.000 45.70745 ? 241 ILE   A C   1 
ATOM   269  O O   . ILE   A 1 45  ? 6.96000   -10.42600 -43.78200 1.000 35.94056 ? 241 ILE   A O   1 
ATOM   270  C CB  . ILE   A 1 45  ? 8.02000   -7.76800  -43.13600 1.000 30.56298 ? 241 ILE   A CB  1 
ATOM   271  C CG1 . ILE   A 1 45  ? 7.97400   -6.27500  -42.81700 1.000 33.51648 ? 241 ILE   A CG1 1 
ATOM   272  C CG2 . ILE   A 1 45  ? 9.44600   -8.22700  -43.38000 1.000 40.43973 ? 241 ILE   A CG2 1 
ATOM   273  C CD1 . ILE   A 1 45  ? 8.76500   -5.91200  -41.57400 1.000 30.38800 ? 241 ILE   A CD1 1 
ATOM   274  N N   . HIS   A 1 46  ? 7.50700   -9.93500  -45.91100 1.000 45.76951 ? 242 HIS   A N   1 
ATOM   275  C CA  . HIS   A 1 46  ? 7.54900   -11.33400 -46.31300 1.000 40.05895 ? 242 HIS   A CA  1 
ATOM   276  C C   . HIS   A 1 46  ? 8.82400   -11.73700 -47.04300 1.000 48.32900 ? 242 HIS   A C   1 
ATOM   277  O O   . HIS   A 1 46  ? 8.98500   -12.92200 -47.35400 1.000 51.25963 ? 242 HIS   A O   1 
ATOM   278  C CB  . HIS   A 1 46  ? 6.33100   -11.67700 -47.18500 1.000 46.56826 ? 242 HIS   A CB  1 
ATOM   279  C CG  . HIS   A 1 46  ? 6.25200   -10.89500 -48.45900 1.000 47.44763 ? 242 HIS   A CG  1 
ATOM   280  N ND1 . HIS   A 1 46  ? 6.80400   -11.33900 -49.64100 1.000 50.64128 ? 242 HIS   A ND1 1 
ATOM   281  C CD2 . HIS   A 1 46  ? 5.67100   -9.70500  -48.73900 1.000 49.18280 ? 242 HIS   A CD2 1 
ATOM   282  C CE1 . HIS   A 1 46  ? 6.57300   -10.45300 -50.59200 1.000 55.15098 ? 242 HIS   A CE1 1 
ATOM   283  N NE2 . HIS   A 1 46  ? 5.88700   -9.45200  -50.07100 1.000 52.68243 ? 242 HIS   A NE2 1 
ATOM   284  N N   . ASP   A 1 47  ? 9.73400   -10.80600 -47.31200 1.000 47.16277 ? 243 ASP   A N   1 
ATOM   285  C CA  . ASP   A 1 47  ? 11.00800  -11.13800 -47.93900 1.000 51.49615 ? 243 ASP   A CA  1 
ATOM   286  C C   . ASP   A 1 47  ? 12.01900  -10.05500 -47.57800 1.000 51.64141 ? 243 ASP   A C   1 
ATOM   287  O O   . ASP   A 1 47  ? 11.72700  -9.13800  -46.80600 1.000 47.86077 ? 243 ASP   A O   1 
ATOM   288  C CB  . ASP   A 1 47  ? 10.85800  -11.29800 -49.45700 1.000 54.48808 ? 243 ASP   A CB  1 
ATOM   289  C CG  . ASP   A 1 47  ? 10.15400  -10.11900 -50.10900 1.000 57.16195 ? 243 ASP   A CG  1 
ATOM   290  O OD1 . ASP   A 1 47  ? 9.80000   -10.22500 -51.30300 1.000 55.94969 ? 243 ASP   A OD1 1 
ATOM   291  O OD2 . ASP   A 1 47  ? 9.95000   -9.08900  -49.43500 1.000 56.92252 ? 243 ASP   A OD2 1 
ATOM   292  N N   . MET   A 1 48  ? 13.22300  -10.17600 -48.14000 1.000 51.35987 ? 244 MET   A N   1 
ATOM   293  C CA  . MET   A 1 48  ? 14.24300  -9.15800  -47.91600 1.000 50.79495 ? 244 MET   A CA  1 
ATOM   294  C C   . MET   A 1 48  ? 13.83400  -7.81700  -48.51200 1.000 48.84164 ? 244 MET   A C   1 
ATOM   295  O O   . MET   A 1 48  ? 14.22300  -6.76600  -47.99000 1.000 51.04032 ? 244 MET   A O   1 
ATOM   296  C CB  . MET   A 1 48  ? 15.58000  -9.60900  -48.50200 1.000 51.94211 ? 244 MET   A CB  1 
ATOM   297  C CG  . MET   A 1 48  ? 16.74900  -9.54600  -47.52900 1.000 52.23695 ? 244 MET   A CG  1 
ATOM   298  S SD  . MET   A 1 48  ? 16.46100  -10.44800 -45.99600 1.000 58.14378 ? 244 MET   A SD  1 
ATOM   299  C CE  . MET   A 1 48  ? 16.82100  -12.12500 -46.51600 1.000 62.01042 ? 244 MET   A CE  1 
ATOM   300  N N   . GLU   A 1 49  ? 13.05300  -7.83400  -49.59400 1.000 48.94234 ? 245 GLU   A N   1 
ATOM   301  C CA  . GLU   A 1 49  ? 12.62800  -6.58900  -50.22400 1.000 52.46383 ? 245 GLU   A CA  1 
ATOM   302  C C   . GLU   A 1 49  ? 11.67800  -5.81100  -49.32100 1.000 47.29134 ? 245 GLU   A C   1 
ATOM   303  O O   . GLU   A 1 49  ? 11.90800  -4.63100  -49.03200 1.000 43.95734 ? 245 GLU   A O   1 
ATOM   304  C CB  . GLU   A 1 49  ? 11.96700  -6.88200  -51.57100 1.000 53.12700 ? 245 GLU   A CB  1 
ATOM   305  C CG  . GLU   A 1 49  ? 11.84200  -5.66800  -52.47400 1.000 62.06262 ? 245 GLU   A CG  1 
ATOM   306  C CD  . GLU   A 1 49  ? 11.02100  -5.94800  -53.71700 1.000 76.23135 ? 245 GLU   A CD  1 
ATOM   307  O OE1 . GLU   A 1 49  ? 10.53900  -4.98000  -54.34300 1.000 75.31246 ? 245 GLU   A OE1 1 
ATOM   308  O OE2 . GLU   A 1 49  ? 10.85600  -7.13600  -54.06900 1.000 78.96278 ? 245 GLU   A OE2 1 
ATOM   309  N N   . THR   A 1 50  ? 10.60100  -6.45700  -48.86700 1.000 43.92256 ? 246 THR   A N   1 
ATOM   310  C CA  . THR   A 1 50  ? 9.64400   -5.76400  -48.01200 1.000 44.88501 ? 246 THR   A CA  1 
ATOM   311  C C   . THR   A 1 50  ? 10.23700  -5.44000  -46.64700 1.000 38.78735 ? 246 THR   A C   1 
ATOM   312  O O   . THR   A 1 50  ? 9.84300   -4.44600  -46.02700 1.000 44.76836 ? 246 THR   A O   1 
ATOM   313  C CB  . THR   A 1 50  ? 8.36100   -6.58900  -47.86700 1.000 46.76591 ? 246 THR   A CB  1 
ATOM   314  O OG1 . THR   A 1 50  ? 8.68100   -7.92100  -47.44700 1.000 43.24318 ? 246 THR   A OG1 1 
ATOM   315  C CG2 . THR   A 1 50  ? 7.60800   -6.63600  -49.18600 1.000 43.32493 ? 246 THR   A CG2 1 
ATOM   316  N N   . LEU   A 1 51  ? 11.19000  -6.24200  -46.16600 1.000 39.18471 ? 247 LEU   A N   1 
ATOM   317  C CA  . LEU   A 1 51  ? 11.87600  -5.87900  -44.93000 1.000 39.99815 ? 247 LEU   A CA  1 
ATOM   318  C C   . LEU   A 1 51  ? 12.56600  -4.52900  -45.07200 1.000 45.47126 ? 247 LEU   A C   1 
ATOM   319  O O   . LEU   A 1 51  ? 12.45500  -3.67000  -44.18900 1.000 33.98208 ? 247 LEU   A O   1 
ATOM   320  C CB  . LEU   A 1 51  ? 12.88400  -6.95900  -44.54100 1.000 37.08522 ? 247 LEU   A CB  1 
ATOM   321  C CG  . LEU   A 1 51  ? 13.77400  -6.63600  -43.33800 1.000 36.39336 ? 247 LEU   A CG  1 
ATOM   322  C CD1 . LEU   A 1 51  ? 12.94100  -6.56800  -42.06500 1.000 37.23516 ? 247 LEU   A CD1 1 
ATOM   323  C CD2 . LEU   A 1 51  ? 14.87900  -7.66900  -43.19300 1.000 46.54536 ? 247 LEU   A CD2 1 
ATOM   324  N N   . CYS   A 1 52  ? 13.25500  -4.31300  -46.19500 1.000 43.53832 ? 248 CYS   A N   1 
ATOM   325  C CA  . CYS   A 1 52  ? 13.96100  -3.05300  -46.40200 1.000 37.96521 ? 248 CYS   A CA  1 
ATOM   326  C C   . CYS   A 1 52  ? 12.99300  -1.89100  -46.58800 1.000 37.46099 ? 248 CYS   A C   1 
ATOM   327  O O   . CYS   A 1 52  ? 13.26000  -0.77600  -46.12400 1.000 43.18883 ? 248 CYS   A O   1 
ATOM   328  C CB  . CYS   A 1 52  ? 14.89700  -3.17300  -47.60200 1.000 49.82861 ? 248 CYS   A CB  1 
ATOM   329  S SG  . CYS   A 1 52  ? 16.24500  -4.33300  -47.33300 1.000 61.64343 ? 248 CYS   A SG  1 
ATOM   330  N N   . MET   A 1 53  ? 11.87200  -2.12300  -47.27400 1.000 40.84214 ? 249 MET   A N   1 
ATOM   331  C CA  . MET   A 1 53  ? 10.87100  -1.07100  -47.42100 1.000 46.51563 ? 249 MET   A CA  1 
ATOM   332  C C   . MET   A 1 53  ? 10.30400  -0.67100  -46.06400 1.000 46.10033 ? 249 MET   A C   1 
ATOM   333  O O   . MET   A 1 53  ? 10.16300  0.51900   -45.76100 1.000 40.95535 ? 249 MET   A O   1 
ATOM   334  C CB  . MET   A 1 53  ? 9.74900   -1.52800  -48.35600 1.000 47.03243 ? 249 MET   A CB  1 
ATOM   335  C CG  . MET   A 1 53  ? 10.09200  -1.45600  -49.83600 1.000 59.80347 ? 249 MET   A CG  1 
ATOM   336  S SD  . MET   A 1 53  ? 9.22700   -2.69800  -50.82000 1.000 80.14911 ? 249 MET   A SD  1 
ATOM   337  C CE  . MET   A 1 53  ? 7.52000   -2.21200  -50.56900 1.000 47.47425 ? 249 MET   A CE  1 
ATOM   338  N N   . ALA   A 1 54  ? 9.98200   -1.66200  -45.23100 1.000 43.39338 ? 250 ALA   A N   1 
ATOM   339  C CA  . ALA   A 1 54  ? 9.44800   -1.38100  -43.90200 1.000 44.76845 ? 250 ALA   A CA  1 
ATOM   340  C C   . ALA   A 1 54  ? 10.45700  -0.61900  -43.05300 1.000 40.98092 ? 250 ALA   A C   1 
ATOM   341  O O   . ALA   A 1 54  ? 10.11200  0.37200   -42.39700 1.000 39.02662 ? 250 ALA   A O   1 
ATOM   342  C CB  . ALA   A 1 54  ? 9.04800   -2.68700  -43.21800 1.000 42.57407 ? 250 ALA   A CB  1 
ATOM   343  N N   . GLU   A 1 55  ? 11.71400  -1.07600  -43.04700 1.000 36.58114 ? 251 GLU   A N   1 
ATOM   344  C CA  . GLU   A 1 55  ? 12.74500  -0.42400  -42.24700 1.000 34.28088 ? 251 GLU   A CA  1 
ATOM   345  C C   . GLU   A 1 55  ? 12.98500  1.00900   -42.70100 1.000 40.74010 ? 251 GLU   A C   1 
ATOM   346  O O   . GLU   A 1 55  ? 13.43600  1.84500   -41.90800 1.000 39.77103 ? 251 GLU   A O   1 
ATOM   347  C CB  . GLU   A 1 55  ? 14.05000  -1.21700  -42.32400 1.000 38.97352 ? 251 GLU   A CB  1 
ATOM   348  C CG  . GLU   A 1 55  ? 14.01400  -2.57400  -41.63700 1.000 45.06769 ? 251 GLU   A CG  1 
ATOM   349  C CD  . GLU   A 1 55  ? 15.25700  -3.39800  -41.92400 1.000 52.40150 ? 251 GLU   A CD  1 
ATOM   350  O OE1 . GLU   A 1 55  ? 15.59200  -3.56200  -43.11700 1.000 48.39029 ? 251 GLU   A OE1 1 
ATOM   351  O OE2 . GLU   A 1 55  ? 15.89500  -3.88500  -40.96400 1.000 44.25789 ? 251 GLU   A OE2 1 
ATOM   352  N N   . LYS   A 1 56  ? 12.69900  1.30900   -43.97100 1.000 40.66863 ? 252 LYS   A N   1 
ATOM   353  C CA  . LYS   A 1 56  ? 12.88300  2.66400   -44.47400 1.000 48.80831 ? 252 LYS   A CA  1 
ATOM   354  C C   . LYS   A 1 56  ? 11.93900  3.64900   -43.79600 1.000 52.09188 ? 252 LYS   A C   1 
ATOM   355  O O   . LYS   A 1 56  ? 12.26300  4.83700   -43.68100 1.000 56.96499 ? 252 LYS   A O   1 
ATOM   356  C CB  . LYS   A 1 56  ? 12.68100  2.68800   -45.99000 1.000 48.27932 ? 252 LYS   A CB  1 
ATOM   357  C CG  . LYS   A 1 56  ? 13.91300  3.10700   -46.77000 1.000 52.59333 ? 252 LYS   A CG  1 
ATOM   358  C CD  . LYS   A 1 56  ? 14.00600  2.36600   -48.09400 1.000 50.74958 ? 252 LYS   A CD  1 
ATOM   359  C CE  . LYS   A 1 56  ? 13.11300  3.00300   -49.14600 1.000 50.98081 ? 252 LYS   A CE  1 
ATOM   360  N NZ  . LYS   A 1 56  ? 13.50200  2.58700   -50.52500 1.000 49.10332 ? 252 LYS   A NZ  1 
ATOM   361  N N   . THR   A 1 57  ? 10.78200  3.17900   -43.33300 1.000 51.02039 ? 253 THR   A N   1 
ATOM   362  C CA  . THR   A 1 57  ? 9.78200   4.03000   -42.69900 1.000 51.72594 ? 253 THR   A CA  1 
ATOM   363  C C   . THR   A 1 57  ? 9.77200   3.92200   -41.18100 1.000 50.76191 ? 253 THR   A C   1 
ATOM   364  O O   . THR   A 1 57  ? 9.67700   4.94200   -40.49100 1.000 50.15973 ? 253 THR   A O   1 
ATOM   365  C CB  . THR   A 1 57  ? 8.38500   3.68800   -43.22700 1.000 51.41886 ? 253 THR   A CB  1 
ATOM   366  O OG1 . THR   A 1 57  ? 8.41800   3.61200   -44.65700 1.000 51.23104 ? 253 THR   A OG1 1 
ATOM   367  C CG2 . THR   A 1 57  ? 7.38000   4.74800   -42.79700 1.000 50.07473 ? 253 THR   A CG2 1 
ATOM   368  N N   . LEU   A 1 58  ? 9.87200   2.71000   -40.64500 1.000 44.33262 ? 254 LEU   A N   1 
ATOM   369  C CA  . LEU   A 1 58  ? 9.67100   2.47100   -39.22300 1.000 47.35606 ? 254 LEU   A CA  1 
ATOM   370  C C   . LEU   A 1 58  ? 10.96100  2.48100   -38.41200 1.000 49.83082 ? 254 LEU   A C   1 
ATOM   371  O O   . LEU   A 1 58  ? 10.90100  2.33200   -37.18700 1.000 47.21578 ? 254 LEU   A O   1 
ATOM   372  C CB  . LEU   A 1 58  ? 8.95100   1.13300   -39.02000 1.000 47.13903 ? 254 LEU   A CB  1 
ATOM   373  C CG  . LEU   A 1 58  ? 7.72000   0.87600   -39.89400 1.000 47.28733 ? 254 LEU   A CG  1 
ATOM   374  C CD1 . LEU   A 1 58  ? 7.18800   -0.53100  -39.66500 1.000 42.74652 ? 254 LEU   A CD1 1 
ATOM   375  C CD2 . LEU   A 1 58  ? 6.63500   1.91500   -39.63300 1.000 42.88010 ? 254 LEU   A CD2 1 
ATOM   376  N N   . VAL   A 1 59  ? 12.11900  2.65200   -39.04700 1.000 47.37801 ? 255 VAL   A N   1 
ATOM   377  C CA  . VAL   A 1 59  ? 13.40200  2.60200   -38.35400 1.000 50.68062 ? 255 VAL   A CA  1 
ATOM   378  C C   . VAL   A 1 59  ? 14.19900  3.85500   -38.68900 1.000 55.64169 ? 255 VAL   A C   1 
ATOM   379  O O   . VAL   A 1 59  ? 14.29500  4.24300   -39.85900 1.000 56.05004 ? 255 VAL   A O   1 
ATOM   380  C CB  . VAL   A 1 59  ? 14.20200  1.33800   -38.72300 1.000 54.92376 ? 255 VAL   A CB  1 
ATOM   381  C CG1 . VAL   A 1 59  ? 15.61100  1.41700   -38.15800 1.000 47.77888 ? 255 VAL   A CG1 1 
ATOM   382  C CG2 . VAL   A 1 59  ? 13.48900  0.09500   -38.21400 1.000 47.84879 ? 255 VAL   A CG2 1 
ATOM   383  N N   . ALA   A 1 60  ? 14.76600  4.48200   -37.66100 1.000 50.85228 ? 256 ALA   A N   1 
ATOM   384  C CA  . ALA   A 1 60  ? 15.63400  5.64000   -37.83800 1.000 52.33474 ? 256 ALA   A CA  1 
ATOM   385  C C   . ALA   A 1 60  ? 16.98300  5.22500   -38.41800 1.000 56.91527 ? 256 ALA   A C   1 
ATOM   386  O O   . ALA   A 1 60  ? 17.76900  4.54200   -37.75800 1.000 51.19039 ? 256 ALA   A O   1 
ATOM   387  C CB  . ALA   A 1 60  ? 15.82700  6.36300   -36.51500 1.000 45.86637 ? 256 ALA   A CB  1 
ATOM   388  N N   . ASN   A 1 69  ? 22.69100  -1.32900  -42.15300 1.000 60.15815 ? 265 ASN   A N   1 
ATOM   389  C CA  . ASN   A 1 69  ? 24.14000  -1.48700  -42.14300 1.000 66.64415 ? 265 ASN   A CA  1 
ATOM   390  C C   . ASN   A 1 69  ? 24.51000  -2.93100  -41.81100 1.000 71.53647 ? 265 ASN   A C   1 
ATOM   391  O O   . ASN   A 1 69  ? 25.26100  -3.57500  -42.54500 1.000 74.23042 ? 265 ASN   A O   1 
ATOM   392  C CB  . ASN   A 1 69  ? 24.77600  -0.52600  -41.13300 1.000 68.08247 ? 265 ASN   A CB  1 
ATOM   393  C CG  . ASN   A 1 69  ? 26.29700  -0.58400  -41.13800 1.000 73.37774 ? 265 ASN   A CG  1 
ATOM   394  O OD1 . ASN   A 1 69  ? 26.90600  -1.32500  -41.90800 1.000 76.50097 ? 265 ASN   A OD1 1 
ATOM   395  N ND2 . ASN   A 1 69  ? 26.91600  0.20600   -40.26600 1.000 72.78434 ? 265 ASN   A ND2 1 
ATOM   396  N N   . LYS   A 1 70  ? 23.97800  -3.43500  -40.70100 1.000 67.38960 ? 266 LYS   A N   1 
ATOM   397  C CA  . LYS   A 1 70  ? 24.28600  -4.78500  -40.25800 1.000 54.23924 ? 266 LYS   A CA  1 
ATOM   398  C C   . LYS   A 1 70  ? 23.46000  -5.80700  -41.03800 1.000 57.29018 ? 266 LYS   A C   1 
ATOM   399  O O   . LYS   A 1 70  ? 22.54500  -5.46600  -41.79300 1.000 57.78666 ? 266 LYS   A O   1 
ATOM   400  C CB  . LYS   A 1 70  ? 24.03700  -4.92100  -38.75700 1.000 54.32817 ? 266 LYS   A CB  1 
ATOM   401  C CG  . LYS   A 1 70  ? 25.29800  -4.82000  -37.91000 1.000 60.69587 ? 266 LYS   A CG  1 
ATOM   402  C CD  . LYS   A 1 70  ? 25.32600  -3.53000  -37.10200 1.000 58.99310 ? 266 LYS   A CD  1 
ATOM   403  C CE  . LYS   A 1 70  ? 26.73800  -3.19300  -36.63800 1.000 63.48981 ? 266 LYS   A CE  1 
ATOM   404  N NZ  . LYS   A 1 70  ? 26.85800  -1.76800  -36.21400 1.000 64.28645 ? 266 LYS   A NZ  1 
ATOM   405  N N   . GLU   A 1 71  ? 23.80000  -7.08100  -40.84600 1.000 50.69417 ? 267 GLU   A N   1 
ATOM   406  C CA  . GLU   A 1 71  ? 23.12500  -8.16400  -41.54900 1.000 49.27478 ? 267 GLU   A CA  1 
ATOM   407  C C   . GLU   A 1 71  ? 21.63900  -8.19400  -41.19500 1.000 51.75499 ? 267 GLU   A C   1 
ATOM   408  O O   . GLU   A 1 71  ? 21.23500  -7.82700  -40.08900 1.000 51.17467 ? 267 GLU   A O   1 
ATOM   409  C CB  . GLU   A 1 71  ? 23.78800  -9.50100  -41.20400 1.000 52.46234 ? 267 GLU   A CB  1 
ATOM   410  C CG  . GLU   A 1 71  ? 23.17600  -10.71800 -41.88300 1.000 55.64274 ? 267 GLU   A CG  1 
ATOM   411  C CD  . GLU   A 1 71  ? 24.00800  -11.97200 -41.68900 1.000 53.97080 ? 267 GLU   A CD  1 
ATOM   412  O OE1 . GLU   A 1 71  ? 24.83700  -11.99400 -40.75500 1.000 57.99093 ? 267 GLU   A OE1 1 
ATOM   413  O OE2 . GLU   A 1 71  ? 23.83200  -12.93400 -42.46700 1.000 55.86902 ? 267 GLU   A OE2 1 
ATOM   414  N N   . ALA   A 1 72  ? 20.82500  -8.64000  -42.16100 1.000 46.64711 ? 268 ALA   A N   1 
ATOM   415  C CA  . ALA   A 1 72  ? 19.37200  -8.58600  -42.01500 1.000 51.12627 ? 268 ALA   A CA  1 
ATOM   416  C C   . ALA   A 1 72  ? 18.90400  -9.29400  -40.75200 1.000 54.53583 ? 268 ALA   A C   1 
ATOM   417  O O   . ALA   A 1 72  ? 17.99800  -8.81200  -40.06200 1.000 45.86522 ? 268 ALA   A O   1 
ATOM   418  C CB  . ALA   A 1 72  ? 18.70000  -9.19500  -43.24600 1.000 48.80212 ? 268 ALA   A CB  1 
ATOM   419  N N   . GLU   A 1 73  ? 19.50700  -10.44000 -40.43000 1.000 51.29581 ? 269 GLU   A N   1 
ATOM   420  C CA  . GLU   A 1 73  ? 19.10700  -11.16400 -39.22900 1.000 46.49039 ? 269 GLU   A CA  1 
ATOM   421  C C   . GLU   A 1 73  ? 19.50700  -10.41700 -37.96400 1.000 49.30360 ? 269 GLU   A C   1 
ATOM   422  O O   . GLU   A 1 73  ? 18.78100  -10.46200 -36.96400 1.000 45.12834 ? 269 GLU   A O   1 
ATOM   423  C CB  . GLU   A 1 73  ? 19.71400  -12.56600 -39.23800 1.000 50.38939 ? 269 GLU   A CB  1 
ATOM   424  C CG  . GLU   A 1 73  ? 18.98100  -13.54800 -40.13600 1.000 48.71295 ? 269 GLU   A CG  1 
ATOM   425  C CD  . GLU   A 1 73  ? 19.46700  -13.49000 -41.57100 1.000 57.13783 ? 269 GLU   A CD  1 
ATOM   426  O OE1 . GLU   A 1 73  ? 20.35200  -12.65700 -41.86200 1.000 51.87470 ? 269 GLU   A OE1 1 
ATOM   427  O OE2 . GLU   A 1 73  ? 18.96700  -14.27500 -42.40700 1.000 53.92375 ? 269 GLU   A OE2 1 
ATOM   428  N N   . VAL   A 1 74  ? 20.65000  -9.72700  -37.98700 1.000 43.09896 ? 270 VAL   A N   1 
ATOM   429  C CA  . VAL   A 1 74  ? 21.06500  -8.94300  -36.82800 1.000 41.77248 ? 270 VAL   A CA  1 
ATOM   430  C C   . VAL   A 1 74  ? 20.15800  -7.72900  -36.65400 1.000 47.53436 ? 270 VAL   A C   1 
ATOM   431  O O   . VAL   A 1 74  ? 19.92000  -7.27700  -35.52700 1.000 44.29438 ? 270 VAL   A O   1 
ATOM   432  C CB  . VAL   A 1 74  ? 22.54600  -8.53900  -36.96800 1.000 46.40127 ? 270 VAL   A CB  1 
ATOM   433  C CG1 . VAL   A 1 74  ? 23.00600  -7.71800  -35.76700 1.000 48.91222 ? 270 VAL   A CG1 1 
ATOM   434  C CG2 . VAL   A 1 74  ? 23.41600  -9.77500  -37.13900 1.000 53.38231 ? 270 VAL   A CG2 1 
ATOM   435  N N   . ARG   A 1 75  ? 19.62500  -7.19400  -37.75500 1.000 43.47318 ? 271 ARG   A N   1 
ATOM   436  C CA  . ARG   A 1 75  ? 18.71600  -6.05600  -37.66200 1.000 46.04435 ? 271 ARG   A CA  1 
ATOM   437  C C   . ARG   A 1 75  ? 17.38400  -6.46200  -37.04000 1.000 43.36769 ? 271 ARG   A C   1 
ATOM   438  O O   . ARG   A 1 75  ? 16.84600  -5.74700  -36.18600 1.000 39.60579 ? 271 ARG   A O   1 
ATOM   439  C CB  . ARG   A 1 75  ? 18.50100  -5.44500  -39.04700 1.000 47.57900 ? 271 ARG   A CB  1 
ATOM   440  C CG  . ARG   A 1 75  ? 19.77900  -4.95100  -39.70800 1.000 48.02709 ? 271 ARG   A CG  1 
ATOM   441  C CD  . ARG   A 1 75  ? 19.48800  -3.93700  -40.80300 1.000 48.09498 ? 271 ARG   A CD  1 
ATOM   442  N NE  . ARG   A 1 75  ? 18.51300  -4.42900  -41.76900 1.000 44.41764 ? 271 ARG   A NE  1 
ATOM   443  C CZ  . ARG   A 1 75  ? 18.82300  -5.00300  -42.92400 1.000 48.29554 ? 271 ARG   A CZ  1 
ATOM   444  N NH1 . ARG   A 1 75  ? 20.08100  -5.20800  -43.27900 1.000 44.99583 ? 271 ARG   A NH1 1 
ATOM   445  N NH2 . ARG   A 1 75  ? 17.84600  -5.37800  -43.74400 1.000 47.31202 ? 271 ARG   A NH2 1 
ATOM   446  N N   . ILE   A 1 76  ? 16.83200  -7.60100  -37.46500 1.000 43.94110 ? 272 ILE   A N   1 
ATOM   447  C CA  . ILE   A 1 76  ? 15.61000  -8.11400  -36.85400 1.000 44.48454 ? 272 ILE   A CA  1 
ATOM   448  C C   . ILE   A 1 76  ? 15.85400  -8.44500  -35.38800 1.000 45.12303 ? 272 ILE   A C   1 
ATOM   449  O O   . ILE   A 1 76  ? 15.01700  -8.15900  -34.52100 1.000 41.41380 ? 272 ILE   A O   1 
ATOM   450  C CB  . ILE   A 1 76  ? 15.10100  -9.34000  -37.63300 1.000 43.88658 ? 272 ILE   A CB  1 
ATOM   451  C CG1 . ILE   A 1 76  ? 14.69900  -8.94000  -39.05200 1.000 35.67289 ? 272 ILE   A CG1 1 
ATOM   452  C CG2 . ILE   A 1 76  ? 13.93200  -9.99200  -36.90300 1.000 40.07816 ? 272 ILE   A CG2 1 
ATOM   453  C CD1 . ILE   A 1 76  ? 14.22800  -10.10200 -39.90200 1.000 38.28685 ? 272 ILE   A CD1 1 
ATOM   454  N N   . PHE   A 1 77  ? 17.00800  -9.05100  -35.09100 1.000 38.82802 ? 273 PHE   A N   1 
ATOM   455  C CA  . PHE   A 1 77  ? 17.38000  -9.35300  -33.71200 1.000 40.49464 ? 273 PHE   A CA  1 
ATOM   456  C C   . PHE   A 1 77  ? 17.32400  -8.10500  -32.84100 1.000 43.69368 ? 273 PHE   A C   1 
ATOM   457  O O   . PHE   A 1 77  ? 16.79800  -8.14000  -31.72200 1.000 41.01618 ? 273 PHE   A O   1 
ATOM   458  C CB  . PHE   A 1 77  ? 18.77800  -9.98600  -33.68900 1.000 41.04844 ? 273 PHE   A CB  1 
ATOM   459  C CG  . PHE   A 1 77  ? 19.52700  -9.80200  -32.39300 1.000 44.26346 ? 273 PHE   A CG  1 
ATOM   460  C CD1 . PHE   A 1 77  ? 19.39100  -10.72000 -31.36400 1.000 48.36558 ? 273 PHE   A CD1 1 
ATOM   461  C CD2 . PHE   A 1 77  ? 20.39700  -8.73500  -32.21700 1.000 49.01635 ? 273 PHE   A CD2 1 
ATOM   462  C CE1 . PHE   A 1 77  ? 20.08500  -10.56500 -30.17600 1.000 46.08347 ? 273 PHE   A CE1 1 
ATOM   463  C CE2 . PHE   A 1 77  ? 21.09100  -8.57200  -31.03100 1.000 51.69303 ? 273 PHE   A CE2 1 
ATOM   464  C CZ  . PHE   A 1 77  ? 20.93600  -9.48900  -30.01000 1.000 54.84459 ? 273 PHE   A CZ  1 
ATOM   465  N N   . HIS   A 1 78  ? 17.84400  -6.98300  -33.34500 1.000 40.66397 ? 274 HIS   A N   1 
ATOM   466  C CA  . HIS   A 1 78  ? 17.83600  -5.75800  -32.55300 1.000 45.74095 ? 274 HIS   A CA  1 
ATOM   467  C C   . HIS   A 1 78  ? 16.42200  -5.21200  -32.39700 1.000 39.87002 ? 274 HIS   A C   1 
ATOM   468  O O   . HIS   A 1 78  ? 16.03100  -4.79800  -31.29900 1.000 39.97587 ? 274 HIS   A O   1 
ATOM   469  C CB  . HIS   A 1 78  ? 18.75500  -4.71300  -33.18500 1.000 47.41431 ? 274 HIS   A CB  1 
ATOM   470  C CG  . HIS   A 1 78  ? 18.85900  -3.44700  -32.39400 1.000 48.89358 ? 274 HIS   A CG  1 
ATOM   471  N ND1 . HIS   A 1 78  ? 19.62700  -3.34400  -31.25400 1.000 51.82440 ? 274 HIS   A ND1 1 
ATOM   472  C CD2 . HIS   A 1 78  ? 18.29400  -2.23000  -32.57800 1.000 47.35977 ? 274 HIS   A CD2 1 
ATOM   473  C CE1 . HIS   A 1 78  ? 19.52900  -2.11900  -30.76800 1.000 54.22656 ? 274 HIS   A CE1 1 
ATOM   474  N NE2 . HIS   A 1 78  ? 18.72700  -1.42200  -31.55400 1.000 51.18821 ? 274 HIS   A NE2 1 
ATOM   475  N N   . CYS   A 1 79  ? 15.63900  -5.20500  -33.48000 1.000 35.11576 ? 275 CYS   A N   1 
ATOM   476  C CA  . CYS   A 1 79  ? 14.24600  -4.78000  -33.37900 1.000 40.76630 ? 275 CYS   A CA  1 
ATOM   477  C C   . CYS   A 1 79  ? 13.45900  -5.68000  -32.43800 1.000 38.80791 ? 275 CYS   A C   1 
ATOM   478  O O   . CYS   A 1 79  ? 12.56100  -5.20800  -31.73100 1.000 42.30911 ? 275 CYS   A O   1 
ATOM   479  C CB  . CYS   A 1 79  ? 13.59400  -4.76600  -34.76200 1.000 42.60508 ? 275 CYS   A CB  1 
ATOM   480  S SG  . CYS   A 1 79  ? 11.79300  -4.50200  -34.74300 1.000 51.77207 ? 275 CYS   A SG  1 
ATOM   481  N N   . CYS   A 1 80  ? 13.78600  -6.97200  -32.40800 1.000 36.87652 ? 276 CYS   A N   1 
ATOM   482  C CA  . CYS   A 1 80  ? 13.11500  -7.88700  -31.49100 1.000 40.94471 ? 276 CYS   A CA  1 
ATOM   483  C C   . CYS   A 1 80  ? 13.48400  -7.57900  -30.04600 1.000 40.92188 ? 276 CYS   A C   1 
ATOM   484  O O   . CYS   A 1 80  ? 12.60700  -7.45600  -29.18200 1.000 38.13653 ? 276 CYS   A O   1 
ATOM   485  C CB  . CYS   A 1 80  ? 13.46800  -9.33200  -31.84400 1.000 31.75815 ? 276 CYS   A CB  1 
ATOM   486  S SG  . CYS   A 1 80  ? 12.53300  -9.99700  -33.23200 1.000 39.32354 ? 276 CYS   A SG  1 
ATOM   487  N N   . GLN   A 1 81  ? 14.78200  -7.44000  -29.76500 1.000 33.15497 ? 277 GLN   A N   1 
ATOM   488  C CA  . GLN   A 1 81  ? 15.21200  -7.21300  -28.39100 1.000 34.57300 ? 277 GLN   A CA  1 
ATOM   489  C C   . GLN   A 1 81  ? 14.81500  -5.82600  -27.89900 1.000 37.77883 ? 277 GLN   A C   1 
ATOM   490  O O   . GLN   A 1 81  ? 14.53100  -5.65000  -26.70800 1.000 34.82586 ? 277 GLN   A O   1 
ATOM   491  C CB  . GLN   A 1 81  ? 16.72200  -7.44300  -28.28300 1.000 47.00296 ? 277 GLN   A CB  1 
ATOM   492  C CG  . GLN   A 1 81  ? 17.57900  -6.19700  -28.24000 1.000 35.45984 ? 277 GLN   A CG  1 
ATOM   493  C CD  . GLN   A 1 81  ? 19.01800  -6.51000  -27.87800 1.000 52.19438 ? 277 GLN   A CD  1 
ATOM   494  O OE1 . GLN   A 1 81  ? 19.31600  -7.57700  -27.34100 1.000 48.60798 ? 277 GLN   A OE1 1 
ATOM   495  N NE2 . GLN   A 1 81  ? 19.92000  -5.58300  -28.17700 1.000 51.12501 ? 277 GLN   A NE2 1 
ATOM   496  N N   . CYS   A 1 82  ? 14.75900  -4.84000  -28.79700 1.000 36.38402 ? 278 CYS   A N   1 
ATOM   497  C CA  . CYS   A 1 82  ? 14.26100  -3.52700  -28.40500 1.000 34.44678 ? 278 CYS   A CA  1 
ATOM   498  C C   . CYS   A 1 82  ? 12.78900  -3.59800  -28.02200 1.000 33.20315 ? 278 CYS   A C   1 
ATOM   499  O O   . CYS   A 1 82  ? 12.35100  -2.92400  -27.08300 1.000 33.79004 ? 278 CYS   A O   1 
ATOM   500  C CB  . CYS   A 1 82  ? 14.48300  -2.52400  -29.53400 1.000 42.95029 ? 278 CYS   A CB  1 
ATOM   501  S SG  . CYS   A 1 82  ? 16.14300  -1.81400  -29.53400 1.000 45.90189 ? 278 CYS   A SG  1 
ATOM   502  N N   . THR   A 1 83  ? 12.01200  -4.41500  -28.73400 1.000 34.54657 ? 279 THR   A N   1 
ATOM   503  C CA  . THR   A 1 83  ? 10.62400  -4.63200  -28.34700 1.000 33.98881 ? 279 THR   A CA  1 
ATOM   504  C C   . THR   A 1 83  ? 10.53700  -5.24700  -26.95500 1.000 28.04849 ? 279 THR   A C   1 
ATOM   505  O O   . THR   A 1 83  ? 9.73800   -4.80500  -26.12100 1.000 29.54740 ? 279 THR   A O   1 
ATOM   506  C CB  . THR   A 1 83  ? 9.93100   -5.52300  -29.37800 1.000 36.28147 ? 279 THR   A CB  1 
ATOM   507  O OG1 . THR   A 1 83  ? 9.86200   -4.83400  -30.63400 1.000 44.34578 ? 279 THR   A OG1 1 
ATOM   508  C CG2 . THR   A 1 83  ? 8.52000   -5.87600  -28.92100 1.000 37.16960 ? 279 THR   A CG2 1 
ATOM   509  N N   . SER   A 1 84  ? 11.37300  -6.25100  -26.67900 1.000 29.86980 ? 280 SER   A N   1 
ATOM   510  C CA  . SER   A 1 84  ? 11.33400  -6.91200  -25.37800 1.000 24.00247 ? 280 SER   A CA  1 
ATOM   511  C C   . SER   A 1 84  ? 11.68200  -5.94800  -24.25200 1.000 28.15992 ? 280 SER   A C   1 
ATOM   512  O O   . SER   A 1 84  ? 11.06800  -5.99100  -23.17900 1.000 28.71581 ? 280 SER   A O   1 
ATOM   513  C CB  . SER   A 1 84  ? 12.27900  -8.11300  -25.37500 1.000 28.44622 ? 280 SER   A CB  1 
ATOM   514  O OG  . SER   A 1 84  ? 11.84500  -9.08600  -26.30500 1.000 30.31892 ? 280 SER   A OG  1 
ATOM   515  N N   . VAL   A 1 85  ? 12.66800  -5.07200  -24.47100 1.000 28.02953 ? 281 VAL   A N   1 
ATOM   516  C CA  . VAL   A 1 85  ? 13.01800  -4.08500  -23.45400 1.000 23.33010 ? 281 VAL   A CA  1 
ATOM   517  C C   . VAL   A 1 85  ? 11.80600  -3.23000  -23.10700 1.000 25.07435 ? 281 VAL   A C   1 
ATOM   518  O O   . VAL   A 1 85  ? 11.53100  -2.96500  -21.93100 1.000 31.90598 ? 281 VAL   A O   1 
ATOM   519  C CB  . VAL   A 1 85  ? 14.20300  -3.22200  -23.92900 1.000 28.44292 ? 281 VAL   A CB  1 
ATOM   520  C CG1 . VAL   A 1 85  ? 14.34300  -1.98300  -23.05700 1.000 31.99623 ? 281 VAL   A CG1 1 
ATOM   521  C CG2 . VAL   A 1 85  ? 15.48600  -4.03400  -23.90700 1.000 39.23589 ? 281 VAL   A CG2 1 
ATOM   522  N N   . GLU   A 1 86  ? 11.05000  -2.80700  -24.12300 1.000 27.84734 ? 282 GLU   A N   1 
ATOM   523  C CA  . GLU   A 1 86  ? 9.84400   -2.02300  -23.87500 1.000 33.37935 ? 282 GLU   A CA  1 
ATOM   524  C C   . GLU   A 1 86  ? 8.79900   -2.84100  -23.12400 1.000 28.55995 ? 282 GLU   A C   1 
ATOM   525  O O   . GLU   A 1 86  ? 8.16000   -2.33900  -22.19200 1.000 24.70887 ? 282 GLU   A O   1 
ATOM   526  C CB  . GLU   A 1 86  ? 9.27900   -1.50500  -25.19700 1.000 33.68398 ? 282 GLU   A CB  1 
ATOM   527  C CG  . GLU   A 1 86  ? 10.28100  -0.70700  -26.02900 1.000 44.08803 ? 282 GLU   A CG  1 
ATOM   528  C CD  . GLU   A 1 86  ? 10.44800  0.73000   -25.55800 1.000 54.50454 ? 282 GLU   A CD  1 
ATOM   529  O OE1 . GLU   A 1 86  ? 9.97400   1.06300   -24.45100 1.000 55.61385 ? 282 GLU   A OE1 1 
ATOM   530  O OE2 . GLU   A 1 86  ? 11.06500  1.52700   -26.29700 1.000 61.84925 ? 282 GLU   A OE2 1 
ATOM   531  N N   . THR   A 1 87  ? 8.61600   -4.10600  -23.50900 1.000 33.23783 ? 283 THR   A N   1 
ATOM   532  C CA  . THR   A 1 87  ? 7.65300   -4.94900  -22.80900 1.000 26.42446 ? 283 THR   A CA  1 
ATOM   533  C C   . THR   A 1 87  ? 8.08300   -5.19300  -21.36700 1.000 26.52424 ? 283 THR   A C   1 
ATOM   534  O O   . THR   A 1 87  ? 7.24300   -5.24100  -20.46100 1.000 26.68399 ? 283 THR   A O   1 
ATOM   535  C CB  . THR   A 1 87  ? 7.46800   -6.27300  -23.55200 1.000 27.98765 ? 283 THR   A CB  1 
ATOM   536  O OG1 . THR   A 1 87  ? 7.10800   -6.01200  -24.91400 1.000 23.31826 ? 283 THR   A OG1 1 
ATOM   537  C CG2 . THR   A 1 87  ? 6.36700   -7.10700  -22.90000 1.000 22.67281 ? 283 THR   A CG2 1 
ATOM   538  N N   . VAL   A 1 88  ? 9.38900   -5.34100  -21.13100 1.000 28.17501 ? 284 VAL   A N   1 
ATOM   539  C CA  . VAL   A 1 88  ? 9.87500   -5.52200  -19.76600 1.000 28.75807 ? 284 VAL   A CA  1 
ATOM   540  C C   . VAL   A 1 88  ? 9.53200   -4.30400  -18.91700 1.000 28.57311 ? 284 VAL   A C   1 
ATOM   541  O O   . VAL   A 1 88  ? 9.15000   -4.43000  -17.74700 1.000 30.65990 ? 284 VAL   A O   1 
ATOM   542  C CB  . VAL   A 1 88  ? 11.38900  -5.80600  -19.76900 1.000 27.44533 ? 284 VAL   A CB  1 
ATOM   543  C CG1 . VAL   A 1 88  ? 11.97400  -5.58700  -18.38700 1.000 30.82443 ? 284 VAL   A CG1 1 
ATOM   544  C CG2 . VAL   A 1 88  ? 11.66100  -7.23000  -20.24600 1.000 24.66530 ? 284 VAL   A CG2 1 
ATOM   545  N N   . THR   A 1 89  ? 9.65200   -3.10900  -19.49600 1.000 29.29779 ? 285 THR   A N   1 
ATOM   546  C CA  . THR   A 1 89  ? 9.33200   -1.89000  -18.76000 1.000 28.06466 ? 285 THR   A CA  1 
ATOM   547  C C   . THR   A 1 89  ? 7.83700   -1.79300  -18.48200 1.000 27.54191 ? 285 THR   A C   1 
ATOM   548  O O   . THR   A 1 89  ? 7.42600   -1.36800  -17.39700 1.000 29.90815 ? 285 THR   A O   1 
ATOM   549  C CB  . THR   A 1 89  ? 9.81600   -0.67200  -19.54600 1.000 35.00327 ? 285 THR   A CB  1 
ATOM   550  O OG1 . THR   A 1 89  ? 11.21100  -0.82500  -19.84700 1.000 35.31462 ? 285 THR   A OG1 1 
ATOM   551  C CG2 . THR   A 1 89  ? 9.61300   0.60400   -18.73800 1.000 37.59242 ? 285 THR   A CG2 1 
ATOM   552  N N   . GLU   A 1 90  ? 7.00900   -2.18300  -19.45300 1.000 27.98408 ? 286 GLU   A N   1 
ATOM   553  C CA  . GLU   A 1 90  ? 5.56800   -2.21100  -19.22600 1.000 27.00982 ? 286 GLU   A CA  1 
ATOM   554  C C   . GLU   A 1 90  ? 5.20000   -3.23600  -18.15900 1.000 27.98119 ? 286 GLU   A C   1 
ATOM   555  O O   . GLU   A 1 90  ? 4.37500   -2.96100  -17.27900 1.000 29.65252 ? 286 GLU   A O   1 
ATOM   556  C CB  . GLU   A 1 90  ? 4.84200   -2.50700  -20.53800 1.000 22.87753 ? 286 GLU   A CB  1 
ATOM   557  C CG  . GLU   A 1 90  ? 4.98700   -1.41700  -21.59600 1.000 29.04388 ? 286 GLU   A CG  1 
ATOM   558  C CD  . GLU   A 1 90  ? 4.28600   -1.77400  -22.89100 1.000 37.84534 ? 286 GLU   A CD  1 
ATOM   559  O OE1 . GLU   A 1 90  ? 3.93900   -2.96000  -23.07000 1.000 30.01785 ? 286 GLU   A OE1 1 
ATOM   560  O OE2 . GLU   A 1 90  ? 4.09000   -0.87500  -23.73700 1.000 38.97868 ? 286 GLU   A OE2 1 
ATOM   561  N N   . LEU   A 1 91  ? 5.81100   -4.42500  -18.21700 1.000 23.29154 ? 287 LEU   A N   1 
ATOM   562  C CA  . LEU   A 1 91  ? 5.56200   -5.44300  -17.20100 1.000 23.16734 ? 287 LEU   A CA  1 
ATOM   563  C C   . LEU   A 1 91  ? 5.98700   -4.97200  -15.82100 1.000 27.71258 ? 287 LEU   A C   1 
ATOM   564  O O   . LEU   A 1 91  ? 5.35100   -5.32000  -14.82000 1.000 28.16571 ? 287 LEU   A O   1 
ATOM   565  C CB  . LEU   A 1 91  ? 6.29700   -6.73200  -17.56100 1.000 24.35010 ? 287 LEU   A CB  1 
ATOM   566  C CG  . LEU   A 1 91  ? 5.60800   -7.66100  -18.55300 1.000 24.18842 ? 287 LEU   A CG  1 
ATOM   567  C CD1 . LEU   A 1 91  ? 6.60000   -8.68200  -19.08900 1.000 27.15629 ? 287 LEU   A CD1 1 
ATOM   568  C CD2 . LEU   A 1 91  ? 4.43000   -8.36000  -17.88800 1.000 27.37789 ? 287 LEU   A CD2 1 
ATOM   569  N N   . THR   A 1 92  ? 7.06000   -4.18400  -15.74800 1.000 26.60985 ? 288 THR   A N   1 
ATOM   570  C CA  . THR   A 1 92  ? 7.52100   -3.67700  -14.46300 1.000 27.35425 ? 288 THR   A CA  1 
ATOM   571  C C   . THR   A 1 92  ? 6.48100   -2.75200  -13.84000 1.000 28.61410 ? 288 THR   A C   1 
ATOM   572  O O   . THR   A 1 92  ? 6.17800   -2.84900  -12.64700 1.000 30.32805 ? 288 THR   A O   1 
ATOM   573  C CB  . THR   A 1 92  ? 8.85500   -2.95300  -14.65000 1.000 31.48373 ? 288 THR   A CB  1 
ATOM   574  O OG1 . THR   A 1 92  ? 9.90100   -3.92300  -14.78400 1.000 36.03903 ? 288 THR   A OG1 1 
ATOM   575  C CG2 . THR   A 1 92  ? 9.15000   -2.07100  -13.45000 1.000 42.44788 ? 288 THR   A CG2 1 
ATOM   576  N N   . GLU   A 1 93  ? 5.91000   -1.85400  -14.64200 1.000 27.98707 ? 289 GLU   A N   1 
ATOM   577  C CA  . GLU   A 1 93  ? 4.86500   -0.98000  -14.12300 1.000 37.90770 ? 289 GLU   A CA  1 
ATOM   578  C C   . GLU   A 1 93  ? 3.59000   -1.75400  -13.82200 1.000 28.59556 ? 289 GLU   A C   1 
ATOM   579  O O   . GLU   A 1 93  ? 2.87900   -1.42800  -12.86500 1.000 27.33490 ? 289 GLU   A O   1 
ATOM   580  C CB  . GLU   A 1 93  ? 4.58900   0.15200   -15.10900 1.000 36.07421 ? 289 GLU   A CB  1 
ATOM   581  C CG  . GLU   A 1 93  ? 5.78700   1.04000   -15.36200 1.000 36.16360 ? 289 GLU   A CG  1 
ATOM   582  C CD  . GLU   A 1 93  ? 6.29700   1.68000   -14.08600 1.000 47.65946 ? 289 GLU   A CD  1 
ATOM   583  O OE1 . GLU   A 1 93  ? 5.54700   2.47400   -13.47800 1.000 46.17172 ? 289 GLU   A OE1 1 
ATOM   584  O OE2 . GLU   A 1 93  ? 7.44700   1.38900   -13.69000 1.000 52.27695 ? 289 GLU   A OE2 1 
ATOM   585  N N   . PHE   A 1 94  ? 3.29400   -2.78200  -14.61900 1.000 29.93120 ? 290 PHE   A N   1 
ATOM   586  C CA  . PHE   A 1 94  ? 2.15100   -3.64100  -14.33600 1.000 27.74473 ? 290 PHE   A CA  1 
ATOM   587  C C   . PHE   A 1 94  ? 2.30000   -4.31500  -12.97700 1.000 27.74373 ? 290 PHE   A C   1 
ATOM   588  O O   . PHE   A 1 94  ? 1.37600   -4.29800  -12.15600 1.000 33.16443 ? 290 PHE   A O   1 
ATOM   589  C CB  . PHE   A 1 94  ? 2.00200   -4.68400  -15.44400 1.000 19.64096 ? 290 PHE   A CB  1 
ATOM   590  C CG  . PHE   A 1 94  ? 0.93700   -5.71000  -15.17400 1.000 25.98487 ? 290 PHE   A CG  1 
ATOM   591  C CD1 . PHE   A 1 94  ? -0.40200  -5.36500  -15.23100 1.000 22.11528 ? 290 PHE   A CD1 1 
ATOM   592  C CD2 . PHE   A 1 94  ? 1.27500   -7.01800  -14.85700 1.000 26.18661 ? 290 PHE   A CD2 1 
ATOM   593  C CE1 . PHE   A 1 94  ? -1.39300  -6.30300  -14.98100 1.000 21.04204 ? 290 PHE   A CE1 1 
ATOM   594  C CE2 . PHE   A 1 94  ? 0.29200   -7.96800  -14.60100 1.000 24.52067 ? 290 PHE   A CE2 1 
ATOM   595  C CZ  . PHE   A 1 94  ? -1.04700  -7.60800  -14.66100 1.000 23.55017 ? 290 PHE   A CZ  1 
ATOM   596  N N   . ALA   A 1 95  ? 3.46500   -4.91600  -12.71900 1.000 28.27972 ? 291 ALA   A N   1 
ATOM   597  C CA  . ALA   A 1 95  ? 3.66800   -5.59400  -11.44300 1.000 28.34112 ? 291 ALA   A CA  1 
ATOM   598  C C   . ALA   A 1 95  ? 3.51900   -4.62500  -10.27700 1.000 28.43748 ? 291 ALA   A C   1 
ATOM   599  O O   . ALA   A 1 95  ? 2.96100   -4.98000  -9.23400  1.000 30.94646 ? 291 ALA   A O   1 
ATOM   600  C CB  . ALA   A 1 95  ? 5.04000   -6.26400  -11.41300 1.000 26.74383 ? 291 ALA   A CB  1 
ATOM   601  N N   . LYS   A 1 96  ? 3.99400   -3.38700  -10.44700 1.000 32.90426 ? 292 LYS   A N   1 
ATOM   602  C CA  . LYS   A 1 96  ? 3.86600   -2.38200  -9.39600  1.000 32.61617 ? 292 LYS   A CA  1 
ATOM   603  C C   . LYS   A 1 96  ? 2.41300   -2.16400  -9.00600  1.000 35.23356 ? 292 LYS   A C   1 
ATOM   604  O O   . LYS   A 1 96  ? 2.12100   -1.85300  -7.84500  1.000 38.63053 ? 292 LYS   A O   1 
ATOM   605  C CB  . LYS   A 1 96  ? 4.48100   -1.06500  -9.86000  1.000 31.73878 ? 292 LYS   A CB  1 
ATOM   606  C CG  . LYS   A 1 96  ? 5.98400   -1.04200  -9.83600  1.000 41.77579 ? 292 LYS   A CG  1 
ATOM   607  C CD  . LYS   A 1 96  ? 6.49900   0.30800   -10.28800 1.000 41.77480 ? 292 LYS   A CD  1 
ATOM   608  C CE  . LYS   A 1 96  ? 7.93900   0.48800   -9.88200  1.000 51.13084 ? 292 LYS   A CE  1 
ATOM   609  N NZ  . LYS   A 1 96  ? 8.29700   -0.47100  -8.79900  1.000 59.65911 ? 292 LYS   A NZ  1 
ATOM   610  N N   . ALA   A 1 97  ? 1.49400   -2.32900  -9.95300  1.000 31.59617 ? 293 ALA   A N   1 
ATOM   611  C CA  . ALA   A 1 97  ? 0.07900   -2.11600  -9.70200  1.000 33.94483 ? 293 ALA   A CA  1 
ATOM   612  C C   . ALA   A 1 97  ? -0.62800  -3.35400  -9.17200  1.000 33.11283 ? 293 ALA   A C   1 
ATOM   613  O O   . ALA   A 1 97  ? -1.80400  -3.26300  -8.80500  1.000 33.30683 ? 293 ALA   A O   1 
ATOM   614  C CB  . ALA   A 1 97  ? -0.61100  -1.63700  -10.98000 1.000 37.71700 ? 293 ALA   A CB  1 
ATOM   615  N N   . ILE   A 1 98  ? 0.04700   -4.49900  -9.12400  1.000 30.85977 ? 294 ILE   A N   1 
ATOM   616  C CA  . ILE   A 1 98  ? -0.51900  -5.69500  -8.50500  1.000 34.57931 ? 294 ILE   A CA  1 
ATOM   617  C C   . ILE   A 1 98  ? -0.53000  -5.48200  -6.99700  1.000 38.41701 ? 294 ILE   A C   1 
ATOM   618  O O   . ILE   A 1 98  ? 0.53700   -5.27100  -6.40100  1.000 36.54520 ? 294 ILE   A O   1 
ATOM   619  C CB  . ILE   A 1 98  ? 0.27400   -6.96000  -8.86900  1.000 33.15460 ? 294 ILE   A CB  1 
ATOM   620  C CG1 . ILE   A 1 98  ? 0.17500   -7.25700  -10.36700 1.000 30.36773 ? 294 ILE   A CG1 1 
ATOM   621  C CG2 . ILE   A 1 98  ? -0.22900  -8.14300  -8.06500  1.000 34.67957 ? 294 ILE   A CG2 1 
ATOM   622  C CD1 . ILE   A 1 98  ? 1.05100   -8.42800  -10.80300 1.000 29.01109 ? 294 ILE   A CD1 1 
ATOM   623  N N   . PRO   A 1 99  ? -1.69200  -5.53100  -6.34400  1.000 37.43032 ? 295 PRO   A N   1 
ATOM   624  C CA  . PRO   A 1 99  ? -1.74700  -5.29000  -4.89300  1.000 41.77484 ? 295 PRO   A CA  1 
ATOM   625  C C   . PRO   A 1 99  ? -0.84100  -6.24400  -4.13000  1.000 41.33080 ? 295 PRO   A C   1 
ATOM   626  O O   . PRO   A 1 99  ? -0.94200  -7.46500  -4.26100  1.000 37.01793 ? 295 PRO   A O   1 
ATOM   627  C CB  . PRO   A 1 99  ? -3.22400  -5.52000  -4.55400  1.000 42.29391 ? 295 PRO   A CB  1 
ATOM   628  C CG  . PRO   A 1 99  ? -3.94900  -5.28100  -5.82900  1.000 45.46680 ? 295 PRO   A CG  1 
ATOM   629  C CD  . PRO   A 1 99  ? -3.02800  -5.75100  -6.92100  1.000 38.28289 ? 295 PRO   A CD  1 
ATOM   630  N N   . GLY   A 1 100 ? 0.05700   -5.67100  -3.33000  1.000 38.34314 ? 296 GLY   A N   1 
ATOM   631  C CA  . GLY   A 1 100 ? 0.97300   -6.43200  -2.51500  1.000 45.16749 ? 296 GLY   A CA  1 
ATOM   632  C C   . GLY   A 1 100 ? 2.36200   -6.58800  -3.09900  1.000 40.56606 ? 296 GLY   A C   1 
ATOM   633  O O   . GLY   A 1 100 ? 3.29500   -6.91400  -2.35700  1.000 47.63817 ? 296 GLY   A O   1 
ATOM   634  N N   . PHE   A 1 101 ? 2.52400   -6.37200  -4.40700  1.000 39.18892 ? 297 PHE   A N   1 
ATOM   635  C CA  . PHE   A 1 101 ? 3.84500   -6.49900  -5.01600  1.000 39.24922 ? 297 PHE   A CA  1 
ATOM   636  C C   . PHE   A 1 101 ? 4.81500   -5.47000  -4.44800  1.000 37.62310 ? 297 PHE   A C   1 
ATOM   637  O O   . PHE   A 1 101 ? 5.96900   -5.79500  -4.14700  1.000 36.14982 ? 297 PHE   A O   1 
ATOM   638  C CB  . PHE   A 1 101 ? 3.74000   -6.35400  -6.53400  1.000 30.82025 ? 297 PHE   A CB  1 
ATOM   639  C CG  . PHE   A 1 101 ? 5.04300   -6.57000  -7.26200  1.000 35.21965 ? 297 PHE   A CG  1 
ATOM   640  C CD1 . PHE   A 1 101 ? 5.43500   -7.84100  -7.65000  1.000 34.08977 ? 297 PHE   A CD1 1 
ATOM   641  C CD2 . PHE   A 1 101 ? 5.87400   -5.49900  -7.56000  1.000 35.01619 ? 297 PHE   A CD2 1 
ATOM   642  C CE1 . PHE   A 1 101 ? 6.63100   -8.04200  -8.31800  1.000 30.38298 ? 297 PHE   A CE1 1 
ATOM   643  C CE2 . PHE   A 1 101 ? 7.07100   -5.69100  -8.22800  1.000 29.32811 ? 297 PHE   A CE2 1 
ATOM   644  C CZ  . PHE   A 1 101 ? 7.45000   -6.96300  -8.60900  1.000 31.63684 ? 297 PHE   A CZ  1 
ATOM   645  N N   . ALA   A 1 102 ? 4.36400   -4.22400  -4.29400  1.000 39.66573 ? 298 ALA   A N   1 
ATOM   646  C CA  . ALA   A 1 102 ? 5.23900   -3.16800  -3.79900  1.000 45.36173 ? 298 ALA   A CA  1 
ATOM   647  C C   . ALA   A 1 102 ? 5.63300   -3.37200  -2.34200  1.000 45.90736 ? 298 ALA   A C   1 
ATOM   648  O O   . ALA   A 1 102 ? 6.67800   -2.86600  -1.92100  1.000 49.27256 ? 298 ALA   A O   1 
ATOM   649  C CB  . ALA   A 1 102 ? 4.56700   -1.80400  -3.97200  1.000 44.48115 ? 298 ALA   A CB  1 
ATOM   650  N N   . ASN   A 1 103 ? 4.82300   -4.09700  -1.56500  1.000 47.48420 ? 299 ASN   A N   1 
ATOM   651  C CA  . ASN   A 1 103 ? 5.14700   -4.33300  -0.16300  1.000 50.81500 ? 299 ASN   A CA  1 
ATOM   652  C C   . ASN   A 1 103 ? 6.30000   -5.31200  0.00900   1.000 52.10647 ? 299 ASN   A C   1 
ATOM   653  O O   . ASN   A 1 103 ? 6.92900   -5.32700  1.07300   1.000 55.42575 ? 299 ASN   A O   1 
ATOM   654  C CB  . ASN   A 1 103 ? 3.92000   -4.85700  0.58100   1.000 53.61903 ? 299 ASN   A CB  1 
ATOM   655  C CG  . ASN   A 1 103 ? 2.72100   -3.94900  0.43600   1.000 55.56306 ? 299 ASN   A CG  1 
ATOM   656  O OD1 . ASN   A 1 103 ? 2.85800   -2.72800  0.34000   1.000 62.28957 ? 299 ASN   A OD1 1 
ATOM   657  N ND2 . ASN   A 1 103 ? 1.53400   -4.54000  0.41800   1.000 56.97550 ? 299 ASN   A ND2 1 
ATOM   658  N N   . LEU   A 1 104 ? 6.57900   -6.13500  -0.99900  1.000 43.49275 ? 300 LEU   A N   1 
ATOM   659  C CA  . LEU   A 1 104 ? 7.68600   -7.07200  -0.91200  1.000 49.34304 ? 300 LEU   A CA  1 
ATOM   660  C C   . LEU   A 1 104 ? 9.01300   -6.32400  -0.87100  1.000 45.59157 ? 300 LEU   A C   1 
ATOM   661  O O   . LEU   A 1 104 ? 9.13300   -5.18700  -1.33600  1.000 48.84506 ? 300 LEU   A O   1 
ATOM   662  C CB  . LEU   A 1 104 ? 7.67500   -8.03700  -2.09700  1.000 45.28799 ? 300 LEU   A CB  1 
ATOM   663  C CG  . LEU   A 1 104 ? 6.33400   -8.67600  -2.45300  1.000 40.91599 ? 300 LEU   A CG  1 
ATOM   664  C CD1 . LEU   A 1 104 ? 6.39000   -9.28900  -3.84200  1.000 37.66075 ? 300 LEU   A CD1 1 
ATOM   665  C CD2 . LEU   A 1 104 ? 5.97000   -9.72300  -1.41800  1.000 42.52396 ? 300 LEU   A CD2 1 
ATOM   666  N N   . ASP   A 1 105 ? 10.01500  -6.97700  -0.29100  1.000 50.69538 ? 301 ASP   A N   1 
ATOM   667  C CA  . ASP   A 1 105 ? 11.35900  -6.42500  -0.31500  1.000 51.71988 ? 301 ASP   A CA  1 
ATOM   668  C C   . ASP   A 1 105 ? 11.81900  -6.26400  -1.75800  1.000 45.42801 ? 301 ASP   A C   1 
ATOM   669  O O   . ASP   A 1 105 ? 11.46300  -7.05200  -2.63800  1.000 41.47194 ? 301 ASP   A O   1 
ATOM   670  C CB  . ASP   A 1 105 ? 12.32200  -7.32200  0.46400   1.000 48.70318 ? 301 ASP   A CB  1 
ATOM   671  C CG  . ASP   A 1 105 ? 12.36000  -6.98600  1.94700   1.000 67.00663 ? 301 ASP   A CG  1 
ATOM   672  O OD1 . ASP   A 1 105 ? 11.46600  -7.44600  2.69200   1.000 69.72986 ? 301 ASP   A OD1 1 
ATOM   673  O OD2 . ASP   A 1 105 ? 13.28500  -6.25900  2.36900   1.000 71.22640 ? 301 ASP   A OD2 1 
ATOM   674  N N   . LEU   A 1 106 ? 12.61200  -5.21800  -1.99600  1.000 44.64949 ? 302 LEU   A N   1 
ATOM   675  C CA  . LEU   A 1 106 ? 12.97900  -4.86300  -3.36200  1.000 42.75220 ? 302 LEU   A CA  1 
ATOM   676  C C   . LEU   A 1 106 ? 13.74200  -5.98600  -4.05700  1.000 42.55208 ? 302 LEU   A C   1 
ATOM   677  O O   . LEU   A 1 106 ? 13.60400  -6.16800  -5.27300  1.000 41.67474 ? 302 LEU   A O   1 
ATOM   678  C CB  . LEU   A 1 106 ? 13.79200  -3.56900  -3.35700  1.000 51.46315 ? 302 LEU   A CB  1 
ATOM   679  C CG  . LEU   A 1 106 ? 14.32300  -3.06400  -4.69800  1.000 51.03163 ? 302 LEU   A CG  1 
ATOM   680  C CD1 . LEU   A 1 106 ? 13.24800  -2.28100  -5.43100  1.000 44.02524 ? 302 LEU   A CD1 1 
ATOM   681  C CD2 . LEU   A 1 106 ? 15.53900  -2.19400  -4.46300  1.000 57.56280 ? 302 LEU   A CD2 1 
ATOM   682  N N   . ASN   A 1 107 ? 14.53400  -6.75900  -3.30900  1.000 46.07107 ? 303 ASN   A N   1 
ATOM   683  C CA  . ASN   A 1 107 ? 15.22400  -7.89600  -3.91000  1.000 45.97283 ? 303 ASN   A CA  1 
ATOM   684  C C   . ASN   A 1 107 ? 14.24300  -8.97300  -4.35600  1.000 36.80463 ? 303 ASN   A C   1 
ATOM   685  O O   . ASN   A 1 107 ? 14.50100  -9.67500  -5.34000  1.000 38.65794 ? 303 ASN   A O   1 
ATOM   686  C CB  . ASN   A 1 107 ? 16.24100  -8.47800  -2.92800  1.000 51.36824 ? 303 ASN   A CB  1 
ATOM   687  C CG  . ASN   A 1 107 ? 17.51700  -7.66000  -2.85500  1.000 57.30907 ? 303 ASN   A CG  1 
ATOM   688  O OD1 . ASN   A 1 107 ? 17.82900  -6.89100  -3.76500  1.000 49.30501 ? 303 ASN   A OD1 1 
ATOM   689  N ND2 . ASN   A 1 107 ? 18.26100  -7.82200  -1.76700  1.000 49.46669 ? 303 ASN   A ND2 1 
ATOM   690  N N   . ASP   A 1 108 ? 13.12100  -9.12400  -3.65000  1.000 42.60984 ? 304 ASP   A N   1 
ATOM   691  C CA  . ASP   A 1 108 ? 12.10300  -10.07100 -4.09100  1.000 35.72387 ? 304 ASP   A CA  1 
ATOM   692  C C   . ASP   A 1 108 ? 11.39600  -9.56600  -5.34300  1.000 34.61971 ? 304 ASP   A C   1 
ATOM   693  O O   . ASP   A 1 108 ? 11.03600  -10.35600 -6.22300  1.000 34.96864 ? 304 ASP   A O   1 
ATOM   694  C CB  . ASP   A 1 108 ? 11.10200  -10.32800 -2.96500  1.000 35.18657 ? 304 ASP   A CB  1 
ATOM   695  C CG  . ASP   A 1 108 ? 11.54500  -11.44200 -2.02800  1.000 37.35185 ? 304 ASP   A CG  1 
ATOM   696  O OD1 . ASP   A 1 108 ? 12.56800  -12.10100 -2.31900  1.000 43.07745 ? 304 ASP   A OD1 1 
ATOM   697  O OD2 . ASP   A 1 108 ? 10.85800  -11.66900 -1.00700  1.000 46.11111 ? 304 ASP   A OD2 1 
ATOM   698  N N   . GLN   A 1 109 ? 11.19700  -8.24900  -5.44400  1.000 35.80303 ? 305 GLN   A N   1 
ATOM   699  C CA  . GLN   A 1 109 ? 10.59400  -7.68200  -6.64600  1.000 33.68268 ? 305 GLN   A CA  1 
ATOM   700  C C   . GLN   A 1 109 ? 11.46400  -7.93000  -7.87000  1.000 36.54308 ? 305 GLN   A C   1 
ATOM   701  O O   . GLN   A 1 109 ? 10.95400  -8.28200  -8.94100  1.000 33.75754 ? 305 GLN   A O   1 
ATOM   702  C CB  . GLN   A 1 109 ? 10.34900  -6.18700  -6.45500  1.000 32.58037 ? 305 GLN   A CB  1 
ATOM   703  C CG  . GLN   A 1 109 ? 9.38600   -5.86200  -5.32900  1.000 36.38171 ? 305 GLN   A CG  1 
ATOM   704  C CD  . GLN   A 1 109 ? 9.09300   -4.37800  -5.22400  1.000 45.63945 ? 305 GLN   A CD  1 
ATOM   705  O OE1 . GLN   A 1 109 ? 9.28400   -3.62700  -6.18100  1.000 45.51078 ? 305 GLN   A OE1 1 
ATOM   706  N NE2 . GLN   A 1 109 ? 8.62500   -3.94800  -4.05800  1.000 43.79395 ? 305 GLN   A NE2 1 
ATOM   707  N N   . VAL   A 1 110 ? 12.78100  -7.75100  -7.73000  1.000 33.27010 ? 306 VAL   A N   1 
ATOM   708  C CA  . VAL   A 1 110 ? 13.69400  -7.99900  -8.84300  1.000 27.54851 ? 306 VAL   A CA  1 
ATOM   709  C C   . VAL   A 1 110 ? 13.64600  -9.46400  -9.26100  1.000 30.38543 ? 306 VAL   A C   1 
ATOM   710  O O   . VAL   A 1 110 ? 13.60100  -9.78400  -10.45600 1.000 30.41864 ? 306 VAL   A O   1 
ATOM   711  C CB  . VAL   A 1 110 ? 15.12400  -7.56700  -8.46500  1.000 37.80876 ? 306 VAL   A CB  1 
ATOM   712  C CG1 . VAL   A 1 110 ? 16.13500  -8.16500  -9.42900  1.000 37.44385 ? 306 VAL   A CG1 1 
ATOM   713  C CG2 . VAL   A 1 110 ? 15.23200  -6.05100  -8.43700  1.000 39.60080 ? 306 VAL   A CG2 1 
ATOM   714  N N   . THR   A 1 111 ? 13.65300  -10.37400 -8.28400  1.000 30.87795 ? 307 THR   A N   1 
ATOM   715  C CA  . THR   A 1 111 ? 13.65500  -11.80300 -8.58400  1.000 30.36340 ? 307 THR   A CA  1 
ATOM   716  C C   . THR   A 1 111 ? 12.41100  -12.20800 -9.36500  1.000 31.99974 ? 307 THR   A C   1 
ATOM   717  O O   . THR   A 1 111 ? 12.50000  -12.93800 -10.36000 1.000 28.78272 ? 307 THR   A O   1 
ATOM   718  C CB  . THR   A 1 111 ? 13.75100  -12.61000 -7.28900  1.000 38.22772 ? 307 THR   A CB  1 
ATOM   719  O OG1 . THR   A 1 111 ? 14.92400  -12.21800 -6.56100  1.000 43.08845 ? 307 THR   A OG1 1 
ATOM   720  C CG2 . THR   A 1 111 ? 13.81400  -14.09800 -7.59900  1.000 37.88873 ? 307 THR   A CG2 1 
ATOM   721  N N   . LEU   A 1 112 ? 11.23900  -11.74400 -8.92000  1.000 31.28404 ? 308 LEU   A N   1 
ATOM   722  C CA  . LEU   A 1 112 ? 9.99100   -12.09200 -9.59600  1.000 31.56863 ? 308 LEU   A CA  1 
ATOM   723  C C   . LEU   A 1 112 ? 9.98700   -11.59400 -11.03400 1.000 28.75325 ? 308 LEU   A C   1 
ATOM   724  O O   . LEU   A 1 112 ? 9.57200   -12.31300 -11.95100 1.000 29.83924 ? 308 LEU   A O   1 
ATOM   725  C CB  . LEU   A 1 112 ? 8.80100   -11.51200 -8.83400  1.000 28.72425 ? 308 LEU   A CB  1 
ATOM   726  C CG  . LEU   A 1 112 ? 8.49100   -12.10500 -7.46100  1.000 28.12876 ? 308 LEU   A CG  1 
ATOM   727  C CD1 . LEU   A 1 112 ? 7.22700   -11.48500 -6.88400  1.000 32.03642 ? 308 LEU   A CD1 1 
ATOM   728  C CD2 . LEU   A 1 112 ? 8.35100   -13.61000 -7.56100  1.000 29.71327 ? 308 LEU   A CD2 1 
ATOM   729  N N   . LEU   A 1 113 ? 10.44900  -10.36400 -11.24900 1.000 29.64129 ? 309 LEU   A N   1 
ATOM   730  C CA  . LEU   A 1 113 ? 10.52600  -9.83000  -12.60000 1.000 27.52266 ? 309 LEU   A CA  1 
ATOM   731  C C   . LEU   A 1 113 ? 11.55800  -10.59000 -13.42400 1.000 24.05998 ? 309 LEU   A C   1 
ATOM   732  O O   . LEU   A 1 113 ? 11.29700  -10.96200 -14.57400 1.000 24.58792 ? 309 LEU   A O   1 
ATOM   733  C CB  . LEU   A 1 113 ? 10.86000  -8.34200  -12.54000 1.000 31.64734 ? 309 LEU   A CB  1 
ATOM   734  C CG  . LEU   A 1 113 ? 9.65100   -7.42800  -12.33600 1.000 33.75287 ? 309 LEU   A CG  1 
ATOM   735  C CD1 . LEU   A 1 113 ? 10.08600  -5.97800  -12.36500 1.000 40.77802 ? 309 LEU   A CD1 1 
ATOM   736  C CD2 . LEU   A 1 113 ? 8.58500   -7.69100  -13.39300 1.000 36.91297 ? 309 LEU   A CD2 1 
ATOM   737  N N   . LYS   A 1 114 ? 12.73200  -10.84700 -12.83800 1.000 31.64626 ? 310 LYS   A N   1 
ATOM   738  C CA  . LYS   A 1 114 ? 13.81600  -11.52000 -13.55300 1.000 30.13891 ? 310 LYS   A CA  1 
ATOM   739  C C   . LYS   A 1 114 ? 13.35200  -12.83000 -14.17800 1.000 27.65123 ? 310 LYS   A C   1 
ATOM   740  O O   . LYS   A 1 114 ? 13.59500  -13.09200 -15.36100 1.000 29.97544 ? 310 LYS   A O   1 
ATOM   741  C CB  . LYS   A 1 114 ? 14.98400  -11.77400 -12.59600 1.000 28.17748 ? 310 LYS   A CB  1 
ATOM   742  C CG  . LYS   A 1 114 ? 16.15100  -12.50600 -13.22700 1.000 36.82075 ? 310 LYS   A CG  1 
ATOM   743  C CD  . LYS   A 1 114 ? 17.24200  -12.77600 -12.20300 1.000 36.30367 ? 310 LYS   A CD  1 
ATOM   744  C CE  . LYS   A 1 114 ? 18.41600  -13.49700 -12.83800 1.000 38.18146 ? 310 LYS   A CE  1 
ATOM   745  N NZ  . LYS   A 1 114 ? 19.09700  -12.64100 -13.85000 1.000 39.24597 ? 310 LYS   A NZ  1 
ATOM   746  N N   . TYR   A 1 115 ? 12.67200  -13.66500 -13.39800 1.000 26.35711 ? 311 TYR   A N   1 
ATOM   747  C CA  . TYR   A 1 115 ? 12.24200  -14.96500 -13.89200 1.000 27.36813 ? 311 TYR   A CA  1 
ATOM   748  C C   . TYR   A 1 115 ? 10.87400  -14.93200 -14.55300 1.000 31.87062 ? 311 TYR   A C   1 
ATOM   749  O O   . TYR   A 1 115 ? 10.53000  -15.86900 -15.28100 1.000 30.68209 ? 311 TYR   A O   1 
ATOM   750  C CB  . TYR   A 1 115 ? 12.23500  -15.97900 -12.74700 1.000 32.51440 ? 311 TYR   A CB  1 
ATOM   751  C CG  . TYR   A 1 115 ? 13.62400  -16.36400 -12.31800 1.000 34.15328 ? 311 TYR   A CG  1 
ATOM   752  C CD1 . TYR   A 1 115 ? 14.30700  -17.38700 -12.95800 1.000 38.34969 ? 311 TYR   A CD1 1 
ATOM   753  C CD2 . TYR   A 1 115 ? 14.26700  -15.68500 -11.29200 1.000 32.70107 ? 311 TYR   A CD2 1 
ATOM   754  C CE1 . TYR   A 1 115 ? 15.58400  -17.73800 -12.57700 1.000 42.01473 ? 311 TYR   A CE1 1 
ATOM   755  C CE2 . TYR   A 1 115 ? 15.54900  -16.02700 -10.90600 1.000 40.65008 ? 311 TYR   A CE2 1 
ATOM   756  C CZ  . TYR   A 1 115 ? 16.20100  -17.05400 -11.55400 1.000 41.30860 ? 311 TYR   A CZ  1 
ATOM   757  O OH  . TYR   A 1 115 ? 17.47600  -17.40300 -11.17800 1.000 49.56197 ? 311 TYR   A OH  1 
ATOM   758  N N   . GLY   A 1 116 ? 10.09800  -13.87600 -14.33600 1.000 30.36496 ? 312 GLY   A N   1 
ATOM   759  C CA  . GLY   A 1 116 ? 8.73800   -13.84400 -14.83100 1.000 26.10482 ? 312 GLY   A CA  1 
ATOM   760  C C   . GLY   A 1 116 ? 8.52500   -13.17600 -16.17400 1.000 26.39485 ? 312 GLY   A C   1 
ATOM   761  O O   . GLY   A 1 116 ? 7.61100   -13.56500 -16.90300 1.000 23.50639 ? 312 GLY   A O   1 
ATOM   762  N N   . VAL   A 1 117 ? 9.34800   -12.18100 -16.52800 1.000 28.67321 ? 313 VAL   A N   1 
ATOM   763  C CA  . VAL   A 1 117 ? 8.99600   -11.31400 -17.65500 1.000 24.65494 ? 313 VAL   A CA  1 
ATOM   764  C C   . VAL   A 1 117 ? 8.92500   -12.09700 -18.96100 1.000 23.42524 ? 313 VAL   A C   1 
ATOM   765  O O   . VAL   A 1 117 ? 8.03700   -11.86000 -19.78500 1.000 27.38552 ? 313 VAL   A O   1 
ATOM   766  C CB  . VAL   A 1 117 ? 9.95900   -10.11300 -17.76300 1.000 25.56651 ? 313 VAL   A CB  1 
ATOM   767  C CG1 . VAL   A 1 117 ? 9.74700   -9.16500  -16.60100 1.000 30.09321 ? 313 VAL   A CG1 1 
ATOM   768  C CG2 . VAL   A 1 117 ? 11.40900  -10.56800 -17.83900 1.000 30.85865 ? 313 VAL   A CG2 1 
ATOM   769  N N   . TYR   A 1 118 ? 9.83000   -13.05400 -19.17200 1.000 25.70442 ? 314 TYR   A N   1 
ATOM   770  C CA  . TYR   A 1 118 ? 9.81300   -13.71100 -20.47400 1.000 21.38366 ? 314 TYR   A CA  1 
ATOM   771  C C   . TYR   A 1 118 ? 8.71300   -14.76000 -20.58600 1.000 22.39645 ? 314 TYR   A C   1 
ATOM   772  O O   . TYR   A 1 118 ? 8.22600   -15.02000 -21.69000 1.000 26.98785 ? 314 TYR   A O   1 
ATOM   773  C CB  . TYR   A 1 118 ? 11.18200  -14.31600 -20.78900 1.000 27.38291 ? 314 TYR   A CB  1 
ATOM   774  C CG  . TYR   A 1 118 ? 12.05100  -13.32300 -21.51900 1.000 26.89990 ? 314 TYR   A CG  1 
ATOM   775  C CD1 . TYR   A 1 118 ? 11.81700  -13.02900 -22.85500 1.000 30.49199 ? 314 TYR   A CD1 1 
ATOM   776  C CD2 . TYR   A 1 118 ? 13.07500  -12.64600 -20.86600 1.000 34.66232 ? 314 TYR   A CD2 1 
ATOM   777  C CE1 . TYR   A 1 118 ? 12.59200  -12.10400 -23.52900 1.000 28.38015 ? 314 TYR   A CE1 1 
ATOM   778  C CE2 . TYR   A 1 118 ? 13.85900  -11.72100 -21.53600 1.000 35.35839 ? 314 TYR   A CE2 1 
ATOM   779  C CZ  . TYR   A 1 118 ? 13.60800  -11.45700 -22.86900 1.000 32.71774 ? 314 TYR   A CZ  1 
ATOM   780  O OH  . TYR   A 1 118 ? 14.37500  -10.54200 -23.55000 1.000 36.11470 ? 314 TYR   A OH  1 
ATOM   781  N N   . GLU   A 1 119 ? 8.29900   -15.36700 -19.47500 1.000 24.27477 ? 315 GLU   A N   1 
ATOM   782  C CA  . GLU   A 1 119 ? 7.09000   -16.18000 -19.51900 1.000 22.55524 ? 315 GLU   A CA  1 
ATOM   783  C C   . GLU   A 1 119 ? 5.89600   -15.32200 -19.91500 1.000 24.31591 ? 315 GLU   A C   1 
ATOM   784  O O   . GLU   A 1 119 ? 5.09900   -15.70100 -20.78200 1.000 22.38481 ? 315 GLU   A O   1 
ATOM   785  C CB  . GLU   A 1 119 ? 6.85700   -16.84500 -18.16400 1.000 25.72323 ? 315 GLU   A CB  1 
ATOM   786  C CG  . GLU   A 1 119 ? 7.81200   -17.98900 -17.86700 1.000 26.13408 ? 315 GLU   A CG  1 
ATOM   787  C CD  . GLU   A 1 119 ? 7.67700   -18.49600 -16.44600 1.000 28.11853 ? 315 GLU   A CD  1 
ATOM   788  O OE1 . GLU   A 1 119 ? 6.61500   -18.26300 -15.83100 1.000 28.44716 ? 315 GLU   A OE1 1 
ATOM   789  O OE2 . GLU   A 1 119 ? 8.62800   -19.12800 -15.94000 1.000 32.90772 ? 315 GLU   A OE2 1 
ATOM   790  N N   . ALA   A 1 120 ? 5.78800   -14.13600 -19.31500 1.000 22.40280 ? 316 ALA   A N   1 
ATOM   791  C CA  . ALA   A 1 120 ? 4.71500   -13.21700 -19.66400 1.000 21.02589 ? 316 ALA   A CA  1 
ATOM   792  C C   . ALA   A 1 120 ? 4.85600   -12.70700 -21.09400 1.000 24.44851 ? 316 ALA   A C   1 
ATOM   793  O O   . ALA   A 1 120 ? 3.85900   -12.58800 -21.81000 1.000 22.67953 ? 316 ALA   A O   1 
ATOM   794  C CB  . ALA   A 1 120 ? 4.69000   -12.05700 -18.67400 1.000 21.24818 ? 316 ALA   A CB  1 
ATOM   795  N N   . ILE   A 1 121 ? 6.08200   -12.40700 -21.53200 1.000 23.89064 ? 317 ILE   A N   1 
ATOM   796  C CA  . ILE   A 1 121 ? 6.28700   -11.88300 -22.88400 1.000 21.15228 ? 317 ILE   A CA  1 
ATOM   797  C C   . ILE   A 1 121 ? 5.77500   -12.86900 -23.92900 1.000 28.94402 ? 317 ILE   A C   1 
ATOM   798  O O   . ILE   A 1 121 ? 5.05600   -12.49600 -24.86400 1.000 23.98347 ? 317 ILE   A O   1 
ATOM   799  C CB  . ILE   A 1 121 ? 7.77400   -11.54900 -23.10600 1.000 24.35476 ? 317 ILE   A CB  1 
ATOM   800  C CG1 . ILE   A 1 121 ? 8.12800   -10.23600 -22.41200 1.000 25.75401 ? 317 ILE   A CG1 1 
ATOM   801  C CG2 . ILE   A 1 121 ? 8.09300   -11.46800 -24.59500 1.000 27.98095 ? 317 ILE   A CG2 1 
ATOM   802  C CD1 . ILE   A 1 121 ? 9.58900   -9.84200  -22.56000 1.000 27.97431 ? 317 ILE   A CD1 1 
ATOM   803  N N   . PHE   A 1 122 ? 6.14000   -14.14300 -23.79300 1.000 25.78751 ? 318 PHE   A N   1 
ATOM   804  C CA  . PHE   A 1 122 ? 5.72400   -15.11300 -24.79600 1.000 24.64666 ? 318 PHE   A CA  1 
ATOM   805  C C   . PHE   A 1 122 ? 4.24300   -15.43900 -24.67200 1.000 24.60560 ? 318 PHE   A C   1 
ATOM   806  O O   . PHE   A 1 122 ? 3.58800   -15.73100 -25.67800 1.000 26.20179 ? 318 PHE   A O   1 
ATOM   807  C CB  . PHE   A 1 122 ? 6.59400   -16.36200 -24.69300 1.000 26.45253 ? 318 PHE   A CB  1 
ATOM   808  C CG  . PHE   A 1 122 ? 8.03800   -16.10500 -25.03200 1.000 26.67962 ? 318 PHE   A CG  1 
ATOM   809  C CD1 . PHE   A 1 122 ? 8.36900   -15.33700 -26.13900 1.000 29.57988 ? 318 PHE   A CD1 1 
ATOM   810  C CD2 . PHE   A 1 122 ? 9.05600   -16.60900 -24.24300 1.000 33.99780 ? 318 PHE   A CD2 1 
ATOM   811  C CE1 . PHE   A 1 122 ? 9.69300   -15.08600 -26.45800 1.000 35.62797 ? 318 PHE   A CE1 1 
ATOM   812  C CE2 . PHE   A 1 122 ? 10.38600  -16.35900 -24.55600 1.000 34.95203 ? 318 PHE   A CE2 1 
ATOM   813  C CZ  . PHE   A 1 122 ? 10.70300  -15.59800 -25.66400 1.000 34.21414 ? 318 PHE   A CZ  1 
ATOM   814  N N   . ALA   A 1 123 ? 3.68800   -15.35600 -23.46200 1.000 24.84684 ? 319 ALA   A N   1 
ATOM   815  C CA  . ALA   A 1 123 ? 2.24400   -15.49100 -23.30600 1.000 26.21415 ? 319 ALA   A CA  1 
ATOM   816  C C   . ALA   A 1 123 ? 1.50500   -14.37100 -24.03700 1.000 20.63202 ? 319 ALA   A C   1 
ATOM   817  O O   . ALA   A 1 123 ? 0.62300   -14.63300 -24.86000 1.000 25.12430 ? 319 ALA   A O   1 
ATOM   818  C CB  . ALA   A 1 123 ? 1.87600   -15.51200 -21.82100 1.000 20.89592 ? 319 ALA   A CB  1 
ATOM   819  N N   . MET   A 1 124 ? 1.86200   -13.11400 -23.75100 1.000 19.31202 ? 320 MET   A N   1 
ATOM   820  C CA  . MET   A 1 124 ? 1.21300   -11.97300 -24.40000 1.000 16.94880 ? 320 MET   A CA  1 
ATOM   821  C C   . MET   A 1 124 ? 1.52500   -11.89800 -25.88700 1.000 23.68416 ? 320 MET   A C   1 
ATOM   822  O O   . MET   A 1 124 ? 0.70900   -11.39000 -26.66600 1.000 25.84761 ? 320 MET   A O   1 
ATOM   823  C CB  . MET   A 1 124 ? 1.63800   -10.66800 -23.73000 1.000 22.12761 ? 320 MET   A CB  1 
ATOM   824  C CG  . MET   A 1 124 ? 1.66800   -10.70000 -22.22500 1.000 31.47347 ? 320 MET   A CG  1 
ATOM   825  S SD  . MET   A 1 124 ? 1.42200   -9.07100  -21.50700 1.000 27.20064 ? 320 MET   A SD  1 
ATOM   826  C CE  . MET   A 1 124 ? 3.14000   -8.57200  -21.42600 1.000 34.74296 ? 320 MET   A CE  1 
ATOM   827  N N   . LEU   A 1 125 ? 2.69900   -12.37400 -26.29800 1.000 24.16227 ? 321 LEU   A N   1 
ATOM   828  C CA  . LEU   A 1 125 ? 3.05000   -12.33400 -27.71000 1.000 26.08689 ? 321 LEU   A CA  1 
ATOM   829  C C   . LEU   A 1 125 ? 2.04900   -13.11300 -28.55200 1.000 26.38703 ? 321 LEU   A C   1 
ATOM   830  O O   . LEU   A 1 125 ? 1.85100   -12.79400 -29.72700 1.000 25.16129 ? 321 LEU   A O   1 
ATOM   831  C CB  . LEU   A 1 125 ? 4.46400   -12.88100 -27.90000 1.000 29.57737 ? 321 LEU   A CB  1 
ATOM   832  C CG  . LEU   A 1 125 ? 5.31400   -12.35900 -29.05300 1.000 38.61523 ? 321 LEU   A CG  1 
ATOM   833  C CD1 . LEU   A 1 125 ? 5.45700   -10.85100 -28.99900 1.000 34.50477 ? 321 LEU   A CD1 1 
ATOM   834  C CD2 . LEU   A 1 125 ? 6.68100   -13.02400 -28.98300 1.000 37.60567 ? 321 LEU   A CD2 1 
ATOM   835  N N   . SER   A 1 126 ? 1.40000   -14.12500 -27.96600 1.000 27.88187 ? 322 SER   A N   1 
ATOM   836  C CA  . SER   A 1 126 ? 0.35900   -14.85700 -28.68100 1.000 32.24306 ? 322 SER   A CA  1 
ATOM   837  C C   . SER   A 1 126 ? -0.74800  -13.93000 -29.16700 1.000 26.77295 ? 322 SER   A C   1 
ATOM   838  O O   . SER   A 1 126 ? -1.36000  -14.18800 -30.20900 1.000 28.38132 ? 322 SER   A O   1 
ATOM   839  C CB  . SER   A 1 126 ? -0.22700  -15.95100 -27.78300 1.000 29.20119 ? 322 SER   A CB  1 
ATOM   840  O OG  . SER   A 1 126 ? 0.79900   -16.69700 -27.15000 1.000 27.23199 ? 322 SER   A OG  1 
ATOM   841  N N   . SER   A 1 127 ? -1.01000  -12.84200 -28.43800 1.000 22.31720 ? 323 SER   A N   1 
ATOM   842  C CA  . SER   A 1 127 ? -2.09700  -11.94500 -28.80700 1.000 27.29125 ? 323 SER   A CA  1 
ATOM   843  C C   . SER   A 1 127 ? -1.84900  -11.26000 -30.14600 1.000 28.31591 ? 323 SER   A C   1 
ATOM   844  O O   . SER   A 1 127 ? -2.80700  -10.86100 -30.81500 1.000 27.48977 ? 323 SER   A O   1 
ATOM   845  C CB  . SER   A 1 127 ? -2.30800  -10.89300 -27.71800 1.000 27.55377 ? 323 SER   A CB  1 
ATOM   846  O OG  . SER   A 1 127 ? -2.56400  -11.49400 -26.46300 1.000 26.97420 ? 323 SER   A OG  1 
ATOM   847  N N   . VAL   A 1 128 ? -0.58700  -11.09700 -30.54600 1.000 26.77677 ? 324 VAL   A N   1 
ATOM   848  C CA  . VAL   A 1 128 ? -0.26400  -10.44600 -31.81100 1.000 26.76011 ? 324 VAL   A CA  1 
ATOM   849  C C   . VAL   A 1 128 ? 0.12500   -11.45400 -32.88900 1.000 31.35984 ? 324 VAL   A C   1 
ATOM   850  O O   . VAL   A 1 128 ? 0.65600   -11.06300 -33.93200 1.000 30.97710 ? 324 VAL   A O   1 
ATOM   851  C CB  . VAL   A 1 128 ? 0.84100   -9.38700  -31.63800 1.000 28.71353 ? 324 VAL   A CB  1 
ATOM   852  C CG1 . VAL   A 1 128 ? 0.42000   -8.33600  -30.62000 1.000 33.71098 ? 324 VAL   A CG1 1 
ATOM   853  C CG2 . VAL   A 1 128 ? 2.16800   -10.02800 -31.24200 1.000 26.89389 ? 324 VAL   A CG2 1 
ATOM   854  N N   . MET   A 1 129 ? -0.12900  -12.73900 -32.66500 1.000 26.77413 ? 325 MET   A N   1 
ATOM   855  C CA  . MET   A 1 129 ? 0.24400   -13.79200 -33.60100 1.000 30.34542 ? 325 MET   A CA  1 
ATOM   856  C C   . MET   A 1 129 ? -0.99000  -14.46700 -34.18100 1.000 39.46889 ? 325 MET   A C   1 
ATOM   857  O O   . MET   A 1 129 ? -1.99800  -14.65200 -33.48900 1.000 36.01228 ? 325 MET   A O   1 
ATOM   858  C CB  . MET   A 1 129 ? 1.11500   -14.85400 -32.92300 1.000 30.37149 ? 325 MET   A CB  1 
ATOM   859  C CG  . MET   A 1 129 ? 2.43900   -14.36500 -32.38700 1.000 32.53656 ? 325 MET   A CG  1 
ATOM   860  S SD  . MET   A 1 129 ? 3.35800   -15.75300 -31.71100 1.000 38.32143 ? 325 MET   A SD  1 
ATOM   861  C CE  . MET   A 1 129 ? 4.89900   -14.98800 -31.27600 1.000 44.56537 ? 325 MET   A CE  1 
ATOM   862  N N   . ASN   A 1 130 ? -0.90700  -14.82400 -35.46100 1.000 33.85527 ? 326 ASN   A N   1 
ATOM   863  C CA  . ASN   A 1 130 ? -1.82100  -15.80700 -36.02300 1.000 36.62198 ? 326 ASN   A CA  1 
ATOM   864  C C   . ASN   A 1 130 ? -0.98500  -16.88800 -36.69100 1.000 34.78612 ? 326 ASN   A C   1 
ATOM   865  O O   . ASN   A 1 130 ? 0.24000   -16.90800 -36.53300 1.000 37.76813 ? 326 ASN   A O   1 
ATOM   866  C CB  . ASN   A 1 130 ? -2.82100  -15.16400 -36.99300 1.000 38.22680 ? 326 ASN   A CB  1 
ATOM   867  C CG  . ASN   A 1 130 ? -2.15600  -14.46600 -38.16900 1.000 33.36895 ? 326 ASN   A CG  1 
ATOM   868  O OD1 . ASN   A 1 130 ? -0.97100  -14.65400 -38.44300 1.000 40.70484 ? 326 ASN   A OD1 1 
ATOM   869  N ND2 . ASN   A 1 130 ? -2.92800  -13.64600 -38.86900 1.000 45.20673 ? 326 ASN   A ND2 1 
ATOM   870  N N   . LYS   A 1 131 ? -1.62600  -17.79400 -37.42800 1.000 34.38929 ? 327 LYS   A N   1 
ATOM   871  C CA  . LYS   A 1 131 ? -0.88300  -18.88100 -38.05300 1.000 41.21776 ? 327 LYS   A CA  1 
ATOM   872  C C   . LYS   A 1 131 ? 0.08100   -18.39400 -39.13000 1.000 38.51893 ? 327 LYS   A C   1 
ATOM   873  O O   . LYS   A 1 131 ? 1.03500   -19.10900 -39.45300 1.000 40.79874 ? 327 LYS   A O   1 
ATOM   874  C CB  . LYS   A 1 131 ? -1.85400  -19.91000 -38.63700 1.000 42.52202 ? 327 LYS   A CB  1 
ATOM   875  C CG  . LYS   A 1 131 ? -2.80600  -19.35700 -39.69000 1.000 39.99660 ? 327 LYS   A CG  1 
ATOM   876  C CD  . LYS   A 1 131 ? -3.64800  -20.47000 -40.30000 1.000 47.37435 ? 327 LYS   A CD  1 
ATOM   877  C CE  . LYS   A 1 131 ? -4.17300  -20.08300 -41.67200 1.000 50.52507 ? 327 LYS   A CE  1 
ATOM   878  N NZ  . LYS   A 1 131 ? -3.13000  -20.24900 -42.72500 1.000 54.63866 ? 327 LYS   A NZ  1 
ATOM   879  N N   . ASP   A 1 132 ? -0.12400  -17.19300 -39.67400 1.000 41.96724 ? 328 ASP   A N   1 
ATOM   880  C CA  . ASP   A 1 132 ? 0.68800   -16.70100 -40.78300 1.000 43.54994 ? 328 ASP   A CA  1 
ATOM   881  C C   . ASP   A 1 132 ? 1.82200   -15.77500 -40.36400 1.000 44.41598 ? 328 ASP   A C   1 
ATOM   882  O O   . ASP   A 1 132 ? 2.81600   -15.66800 -41.09300 1.000 41.83747 ? 328 ASP   A O   1 
ATOM   883  C CB  . ASP   A 1 132 ? -0.19300  -15.97200 -41.80100 1.000 41.23702 ? 328 ASP   A CB  1 
ATOM   884  C CG  . ASP   A 1 132 ? -1.29500  -16.85300 -42.35000 1.000 51.14431 ? 328 ASP   A CG  1 
ATOM   885  O OD1 . ASP   A 1 132 ? -1.12800  -18.09100 -42.33100 1.000 51.90435 ? 328 ASP   A OD1 1 
ATOM   886  O OD2 . ASP   A 1 132 ? -2.32300  -16.31000 -42.80600 1.000 52.90592 ? 328 ASP   A OD2 1 
ATOM   887  N N   . GLY   A 1 133 ? 1.71000   -15.09500 -39.23100 1.000 33.99644 ? 329 GLY   A N   1 
ATOM   888  C CA  . GLY   A 1 133 ? 2.75600   -14.16900 -38.84000 1.000 35.30169 ? 329 GLY   A CA  1 
ATOM   889  C C   . GLY   A 1 133 ? 2.42500   -13.47500 -37.54000 1.000 38.36906 ? 329 GLY   A C   1 
ATOM   890  O O   . GLY   A 1 133 ? 1.56400   -13.92400 -36.78200 1.000 31.79772 ? 329 GLY   A O   1 
ATOM   891  N N   . MET   A 1 134 ? 3.12400   -12.36900 -37.28500 1.000 31.64683 ? 330 MET   A N   1 
ATOM   892  C CA  . MET   A 1 134 ? 2.93500   -11.64500 -36.03800 1.000 30.70627 ? 330 MET   A CA  1 
ATOM   893  C C   . MET   A 1 134 ? 3.13200   -10.15100 -36.26100 1.000 36.62235 ? 330 MET   A C   1 
ATOM   894  O O   . MET   A 1 134 ? 3.91900   -9.72900  -37.11400 1.000 32.14224 ? 330 MET   A O   1 
ATOM   895  C CB  . MET   A 1 134 ? 3.87900   -12.15900 -34.94200 1.000 32.77280 ? 330 MET   A CB  1 
ATOM   896  C CG  . MET   A 1 134 ? 5.33300   -11.80600 -35.12700 1.000 35.04609 ? 330 MET   A CG  1 
ATOM   897  S SD  . MET   A 1 134 ? 6.31500   -12.25700 -33.68400 1.000 45.26942 ? 330 MET   A SD  1 
ATOM   898  C CE  . MET   A 1 134 ? 7.96300   -11.83300 -34.24400 1.000 39.45871 ? 330 MET   A CE  1 
ATOM   899  N N   . LEU   A 1 135 ? 2.39700   -9.35800  -35.48400 1.000 29.10059 ? 331 LEU   A N   1 
ATOM   900  C CA  . LEU   A 1 135 ? 2.52300   -7.91000  -35.55200 1.000 27.31871 ? 331 LEU   A CA  1 
ATOM   901  C C   . LEU   A 1 135 ? 3.83900   -7.46200  -34.93000 1.000 29.28446 ? 331 LEU   A C   1 
ATOM   902  O O   . LEU   A 1 135 ? 4.30800   -8.03400  -33.94100 1.000 31.31601 ? 331 LEU   A O   1 
ATOM   903  C CB  . LEU   A 1 135 ? 1.35100   -7.23600  -34.83800 1.000 30.68124 ? 331 LEU   A CB  1 
ATOM   904  C CG  . LEU   A 1 135 ? -0.02300  -7.27500  -35.50900 1.000 37.14934 ? 331 LEU   A CG  1 
ATOM   905  C CD1 . LEU   A 1 135 ? -1.06700  -6.61800  -34.61300 1.000 39.71673 ? 331 LEU   A CD1 1 
ATOM   906  C CD2 . LEU   A 1 135 ? 0.01100   -6.60100  -36.87500 1.000 36.21950 ? 331 LEU   A CD2 1 
ATOM   907  N N   . VAL   A 1 136 ? 4.43300   -6.42300  -35.51700 1.000 30.68117 ? 332 VAL   A N   1 
ATOM   908  C CA  . VAL   A 1 136 ? 5.67400   -5.83200  -35.03800 1.000 25.13591 ? 332 VAL   A CA  1 
ATOM   909  C C   . VAL   A 1 136 ? 5.56500   -4.31700  -35.18000 1.000 23.20064 ? 332 VAL   A C   1 
ATOM   910  O O   . VAL   A 1 136 ? 4.66200   -3.79400  -35.83600 1.000 28.68160 ? 332 VAL   A O   1 
ATOM   911  C CB  . VAL   A 1 136 ? 6.90500   -6.35800  -35.80700 1.000 35.81163 ? 332 VAL   A CB  1 
ATOM   912  C CG1 . VAL   A 1 136 ? 7.20200   -7.80500  -35.42500 1.000 37.95946 ? 332 VAL   A CG1 1 
ATOM   913  C CG2 . VAL   A 1 136 ? 6.68300   -6.23200  -37.30900 1.000 32.27439 ? 332 VAL   A CG2 1 
ATOM   914  N N   . ALA   A 1 137 ? 6.49700   -3.61900  -34.53800 1.000 26.89573 ? 333 ALA   A N   1 
ATOM   915  C CA  . ALA   A 1 137 ? 6.60700   -2.16200  -34.63000 1.000 31.06005 ? 333 ALA   A CA  1 
ATOM   916  C C   . ALA   A 1 137 ? 5.31200   -1.47800  -34.19600 1.000 28.10674 ? 333 ALA   A C   1 
ATOM   917  O O   . ALA   A 1 137 ? 4.74500   -0.65500  -34.91800 1.000 30.41563 ? 333 ALA   A O   1 
ATOM   918  C CB  . ALA   A 1 137 ? 7.01200   -1.73100  -36.04300 1.000 30.17175 ? 333 ALA   A CB  1 
ATOM   919  N N   . TYR   A 1 138 ? 4.84300   -1.83800  -33.00000 1.000 30.43303 ? 334 TYR   A N   1 
ATOM   920  C CA  . TYR   A 1 138 ? 3.67100   -1.21300  -32.38400 1.000 32.50461 ? 334 TYR   A CA  1 
ATOM   921  C C   . TYR   A 1 138 ? 2.46100   -1.24000  -33.31500 1.000 32.74413 ? 334 TYR   A C   1 
ATOM   922  O O   . TYR   A 1 138 ? 1.74000   -0.25000  -33.46900 1.000 31.79646 ? 334 TYR   A O   1 
ATOM   923  C CB  . TYR   A 1 138 ? 4.00600   0.20900   -31.92700 1.000 26.12515 ? 334 TYR   A CB  1 
ATOM   924  C CG  . TYR   A 1 138 ? 5.18300   0.22000   -30.97700 1.000 37.34047 ? 334 TYR   A CG  1 
ATOM   925  C CD1 . TYR   A 1 138 ? 4.99800   0.02300   -29.61500 1.000 43.01834 ? 334 TYR   A CD1 1 
ATOM   926  C CD2 . TYR   A 1 138 ? 6.48100   0.38300   -31.44400 1.000 41.42698 ? 334 TYR   A CD2 1 
ATOM   927  C CE1 . TYR   A 1 138 ? 6.06600   0.01100   -28.74400 1.000 41.93612 ? 334 TYR   A CE1 1 
ATOM   928  C CE2 . TYR   A 1 138 ? 7.55700   0.37000   -30.57800 1.000 45.16015 ? 334 TYR   A CE2 1 
ATOM   929  C CZ  . TYR   A 1 138 ? 7.34200   0.18600   -29.23000 1.000 45.48133 ? 334 TYR   A CZ  1 
ATOM   930  O OH  . TYR   A 1 138 ? 8.40700   0.17300   -28.36200 1.000 57.39353 ? 334 TYR   A OH  1 
ATOM   931  N N   . GLY   A 1 139 ? 2.24000   -2.39400  -33.94200 1.000 28.30483 ? 335 GLY   A N   1 
ATOM   932  C CA  . GLY   A 1 139 ? 1.09900   -2.60700  -34.80300 1.000 36.04080 ? 335 GLY   A CA  1 
ATOM   933  C C   . GLY   A 1 139 ? 1.25900   -2.12900  -36.22700 1.000 36.98874 ? 335 GLY   A C   1 
ATOM   934  O O   . GLY   A 1 139 ? 0.33400   -2.30900  -37.03100 1.000 36.70718 ? 335 GLY   A O   1 
ATOM   935  N N   . ASN   A 1 140 ? 2.39900   -1.53700  -36.57700 1.000 30.73082 ? 336 ASN   A N   1 
ATOM   936  C CA  . ASN   A 1 140 ? 2.57000   -0.95900  -37.90100 1.000 31.05368 ? 336 ASN   A CA  1 
ATOM   937  C C   . ASN   A 1 140 ? 3.13900   -1.94000  -38.91800 1.000 37.92373 ? 336 ASN   A C   1 
ATOM   938  O O   . ASN   A 1 140 ? 3.06300   -1.67100  -40.12200 1.000 34.68398 ? 336 ASN   A O   1 
ATOM   939  C CB  . ASN   A 1 140 ? 3.46700   0.28000   -37.81700 1.000 27.33574 ? 336 ASN   A CB  1 
ATOM   940  C CG  . ASN   A 1 140 ? 2.82400   1.40700   -37.03200 1.000 26.37053 ? 336 ASN   A CG  1 
ATOM   941  O OD1 . ASN   A 1 140 ? 1.90000   2.06400   -37.51400 1.000 36.50342 ? 336 ASN   A OD1 1 
ATOM   942  N ND2 . ASN   A 1 140 ? 3.30900   1.63600   -35.81900 1.000 24.80330 ? 336 ASN   A ND2 1 
ATOM   943  N N   . GLY   A 1 141 ? 3.69800   -3.06700  -38.47400 1.000 36.53543 ? 337 GLY   A N   1 
ATOM   944  C CA  . GLY   A 1 141 ? 4.22200   -4.05900  -39.38300 1.000 33.12192 ? 337 GLY   A CA  1 
ATOM   945  C C   . GLY   A 1 141 ? 3.68600   -5.43900  -39.05400 1.000 30.34187 ? 337 GLY   A C   1 
ATOM   946  O O   . GLY   A 1 141 ? 3.20900   -5.70300  -37.95000 1.000 30.49861 ? 337 GLY   A O   1 
ATOM   947  N N   . PHE   A 1 142 ? 3.77100   -6.32300  -40.04600 1.000 30.32604 ? 338 PHE   A N   1 
ATOM   948  C CA  . PHE   A 1 142 ? 3.34700   -7.71400  -39.89700 1.000 32.68476 ? 338 PHE   A CA  1 
ATOM   949  C C   . PHE   A 1 142 ? 4.35200   -8.57600  -40.64700 1.000 35.57968 ? 338 PHE   A C   1 
ATOM   950  O O   . PHE   A 1 142 ? 4.39500   -8.54700  -41.88100 1.000 38.31497 ? 338 PHE   A O   1 
ATOM   951  C CB  . PHE   A 1 142 ? 1.92800   -7.92000  -40.43000 1.000 28.86672 ? 338 PHE   A CB  1 
ATOM   952  C CG  . PHE   A 1 142 ? 1.44200   -9.34500  -40.35700 1.000 37.67085 ? 338 PHE   A CG  1 
ATOM   953  C CD1 . PHE   A 1 142 ? 0.82600   -9.82400  -39.20900 1.000 32.04338 ? 338 PHE   A CD1 1 
ATOM   954  C CD2 . PHE   A 1 142 ? 1.58200   -10.19700 -41.43900 1.000 40.11942 ? 338 PHE   A CD2 1 
ATOM   955  C CE1 . PHE   A 1 142 ? 0.37100   -11.12700 -39.13800 1.000 31.66478 ? 338 PHE   A CE1 1 
ATOM   956  C CE2 . PHE   A 1 142 ? 1.13000   -11.50600 -41.37500 1.000 42.73525 ? 338 PHE   A CE2 1 
ATOM   957  C CZ  . PHE   A 1 142 ? 0.52100   -11.96900 -40.22400 1.000 41.67401 ? 338 PHE   A CZ  1 
ATOM   958  N N   . ILE   A 1 143 ? 5.16600   -9.32600  -39.90900 1.000 30.34754 ? 339 ILE   A N   1 
ATOM   959  C CA  . ILE   A 1 143 ? 6.21100   -10.16100 -40.49000 1.000 37.05325 ? 339 ILE   A CA  1 
ATOM   960  C C   . ILE   A 1 143 ? 5.69100   -11.58800 -40.58500 1.000 44.91472 ? 339 ILE   A C   1 
ATOM   961  O O   . ILE   A 1 143 ? 5.05200   -12.09600 -39.65200 1.000 32.68123 ? 339 ILE   A O   1 
ATOM   962  C CB  . ILE   A 1 143 ? 7.52000   -10.07000 -39.67500 1.000 34.27263 ? 339 ILE   A CB  1 
ATOM   963  C CG1 . ILE   A 1 143 ? 8.68300   -10.70300 -40.44200 1.000 33.47196 ? 339 ILE   A CG1 1 
ATOM   964  C CG2 . ILE   A 1 143 ? 7.37400   -10.67200 -38.27800 1.000 33.18682 ? 339 ILE   A CG2 1 
ATOM   965  C CD1 . ILE   A 1 143 ? 10.04900  -10.32500 -39.90100 1.000 40.38558 ? 339 ILE   A CD1 1 
ATOM   966  N N   . THR   A 1 144 ? 5.92400   -12.22700 -41.72900 1.000 38.45730 ? 340 THR   A N   1 
ATOM   967  C CA  . THR   A 1 144 ? 5.34100   -13.53800 -41.97100 1.000 37.57061 ? 340 THR   A CA  1 
ATOM   968  C C   . THR   A 1 144 ? 6.13900   -14.62600 -41.26700 1.000 36.24132 ? 340 THR   A C   1 
ATOM   969  O O   . THR   A 1 144 ? 7.35300   -14.51500 -41.06600 1.000 35.88966 ? 340 THR   A O   1 
ATOM   970  C CB  . THR   A 1 144 ? 5.26500   -13.84400 -43.46800 1.000 37.90312 ? 340 THR   A CB  1 
ATOM   971  O OG1 . THR   A 1 144 ? 6.58900   -13.95500 -44.00300 1.000 43.06908 ? 340 THR   A OG1 1 
ATOM   972  C CG2 . THR   A 1 144 ? 4.51100   -12.74700 -44.19800 1.000 43.46846 ? 340 THR   A CG2 1 
ATOM   973  N N   . ARG   A 1 145 ? 5.43000   -15.69000 -40.88900 1.000 38.62897 ? 341 ARG   A N   1 
ATOM   974  C CA  . ARG   A 1 145 ? 6.07000   -16.82900 -40.24100 1.000 39.19370 ? 341 ARG   A CA  1 
ATOM   975  C C   . ARG   A 1 145 ? 7.08900   -17.49000 -41.16300 1.000 41.82792 ? 341 ARG   A C   1 
ATOM   976  O O   . ARG   A 1 145 ? 8.13800   -17.96400 -40.70800 1.000 35.09224 ? 341 ARG   A O   1 
ATOM   977  C CB  . ARG   A 1 145 ? 4.99500   -17.82700 -39.81100 1.000 45.62981 ? 341 ARG   A CB  1 
ATOM   978  C CG  . ARG   A 1 145 ? 5.46800   -18.96900 -38.94100 1.000 41.87482 ? 341 ARG   A CG  1 
ATOM   979  C CD  . ARG   A 1 145 ? 4.26200   -19.70600 -38.38500 1.000 38.71320 ? 341 ARG   A CD  1 
ATOM   980  N NE  . ARG   A 1 145 ? 4.63000   -20.84800 -37.56000 1.000 44.41879 ? 341 ARG   A NE  1 
ATOM   981  C CZ  . ARG   A 1 145 ? 3.76700   -21.74400 -37.09900 1.000 43.64827 ? 341 ARG   A CZ  1 
ATOM   982  N NH1 . ARG   A 1 145 ? 2.47000   -21.64900 -37.35200 1.000 44.08694 ? 341 ARG   A NH1 1 
ATOM   983  N NH2 . ARG   A 1 145 ? 4.21400   -22.75600 -36.36200 1.000 47.07294 ? 341 ARG   A NH2 1 
ATOM   984  N N   . GLU   A 1 146 ? 6.80400   -17.52100 -42.46500 1.000 44.84524 ? 342 GLU   A N   1 
ATOM   985  C CA  . GLU   A 1 146 ? 7.70600   -18.18400 -43.40200 1.000 50.71408 ? 342 GLU   A CA  1 
ATOM   986  C C   . GLU   A 1 146 ? 9.00400   -17.40500 -43.57500 1.000 48.40935 ? 342 GLU   A C   1 
ATOM   987  O O   . GLU   A 1 146 ? 10.07400  -18.00300 -43.74100 1.000 49.95713 ? 342 GLU   A O   1 
ATOM   988  C CB  . GLU   A 1 146 ? 7.01000   -18.37500 -44.74600 1.000 47.91734 ? 342 GLU   A CB  1 
ATOM   989  C CG  . GLU   A 1 146 ? 5.81800   -19.31000 -44.68200 1.000 57.39280 ? 342 GLU   A CG  1 
ATOM   990  C CD  . GLU   A 1 146 ? 6.22700   -20.77000 -44.67800 1.000 72.08967 ? 342 GLU   A CD  1 
ATOM   991  O OE1 . GLU   A 1 146 ? 6.40200   -21.33800 -43.57900 1.000 70.57727 ? 342 GLU   A OE1 1 
ATOM   992  O OE2 . GLU   A 1 146 ? 6.38100   -21.34900 -45.77500 1.000 78.02843 ? 342 GLU   A OE2 1 
ATOM   993  N N   . PHE   A 1 147 ? 8.93300   -16.07100 -43.53900 1.000 46.71037 ? 343 PHE   A N   1 
ATOM   994  C CA  . PHE   A 1 147 ? 10.13800  -15.26700 -43.71400 1.000 42.85501 ? 343 PHE   A CA  1 
ATOM   995  C C   . PHE   A 1 147 ? 11.11300  -15.47500 -42.56200 1.000 46.17774 ? 343 PHE   A C   1 
ATOM   996  O O   . PHE   A 1 147 ? 12.33100  -15.52800 -42.77200 1.000 45.43595 ? 343 PHE   A O   1 
ATOM   997  C CB  . PHE   A 1 147 ? 9.76600   -13.79000 -43.85200 1.000 43.34755 ? 343 PHE   A CB  1 
ATOM   998  C CG  . PHE   A 1 147 ? 10.95200  -12.87400 -43.93600 1.000 48.59654 ? 343 PHE   A CG  1 
ATOM   999  C CD1 . PHE   A 1 147 ? 11.90100  -13.03800 -44.93200 1.000 50.99612 ? 343 PHE   A CD1 1 
ATOM   1000 C CD2 . PHE   A 1 147 ? 11.12300  -11.85000 -43.01700 1.000 46.80024 ? 343 PHE   A CD2 1 
ATOM   1001 C CE1 . PHE   A 1 147 ? 12.99600  -12.19900 -45.01300 1.000 50.74927 ? 343 PHE   A CE1 1 
ATOM   1002 C CE2 . PHE   A 1 147 ? 12.21800  -11.00500 -43.09200 1.000 45.91983 ? 343 PHE   A CE2 1 
ATOM   1003 C CZ  . PHE   A 1 147 ? 13.15600  -11.18200 -44.09100 1.000 48.38510 ? 343 PHE   A CZ  1 
ATOM   1004 N N   . LEU   A 1 148 ? 10.59800  -15.59800 -41.33600 1.000 36.57747 ? 344 LEU   A N   1 
ATOM   1005 C CA  . LEU   A 1 148 ? 11.46900  -15.85300 -40.19500 1.000 40.64171 ? 344 LEU   A CA  1 
ATOM   1006 C C   . LEU   A 1 148 ? 12.16500  -17.20100 -40.32900 1.000 38.08315 ? 344 LEU   A C   1 
ATOM   1007 O O   . LEU   A 1 148 ? 13.35200  -17.33200 -40.00700 1.000 47.36837 ? 344 LEU   A O   1 
ATOM   1008 C CB  . LEU   A 1 148 ? 10.66400  -15.79100 -38.89900 1.000 36.23602 ? 344 LEU   A CB  1 
ATOM   1009 C CG  . LEU   A 1 148 ? 10.06500  -14.41400 -38.60400 1.000 37.14781 ? 344 LEU   A CG  1 
ATOM   1010 C CD1 . LEU   A 1 148 ? 9.01500   -14.49800 -37.49400 1.000 37.35280 ? 344 LEU   A CD1 1 
ATOM   1011 C CD2 . LEU   A 1 148 ? 11.15700  -13.42000 -38.25900 1.000 32.23754 ? 344 LEU   A CD2 1 
ATOM   1012 N N   . LYS   A 1 149 ? 11.44000  -18.21600 -40.80300 1.000 44.30733 ? 345 LYS   A N   1 
ATOM   1013 C CA  . LYS   A 1 149 ? 12.05700  -19.51700 -41.03600 1.000 49.44189 ? 345 LYS   A CA  1 
ATOM   1014 C C   . LYS   A 1 149 ? 13.05400  -19.46300 -42.18500 1.000 54.45722 ? 345 LYS   A C   1 
ATOM   1015 O O   . LYS   A 1 149 ? 14.07000  -20.16700 -42.15500 1.000 51.40552 ? 345 LYS   A O   1 
ATOM   1016 C CB  . LYS   A 1 149 ? 10.98500  -20.57000 -41.32000 1.000 47.95416 ? 345 LYS   A CB  1 
ATOM   1017 C CG  . LYS   A 1 149 ? 10.12500  -20.92900 -40.12000 1.000 53.12920 ? 345 LYS   A CG  1 
ATOM   1018 C CD  . LYS   A 1 149 ? 9.56000   -22.33900 -40.24100 1.000 59.93473 ? 345 LYS   A CD  1 
ATOM   1019 C CE  . LYS   A 1 149 ? 9.02800   -22.61700 -41.63900 1.000 60.62473 ? 345 LYS   A CE  1 
ATOM   1020 N NZ  . LYS   A 1 149 ? 7.57000   -22.34300 -41.74200 1.000 65.13324 ? 345 LYS   A NZ  1 
ATOM   1021 N N   . SER   A 1 150 ? 12.78700  -18.63300 -43.19600 1.000 55.33336 ? 346 SER   A N   1 
ATOM   1022 C CA  . SER   A 1 150 ? 13.68200  -18.50600 -44.34100 1.000 51.26269 ? 346 SER   A CA  1 
ATOM   1023 C C   . SER   A 1 150 ? 15.00700  -17.84400 -43.98900 1.000 53.80022 ? 346 SER   A C   1 
ATOM   1024 O O   . SER   A 1 150 ? 15.91000  -17.82300 -44.83200 1.000 55.86148 ? 346 SER   A O   1 
ATOM   1025 C CB  . SER   A 1 150 ? 12.99000  -17.72300 -45.45900 1.000 52.56719 ? 346 SER   A CB  1 
ATOM   1026 O OG  . SER   A 1 150 ? 13.29600  -16.34200 -45.38400 1.000 53.02271 ? 346 SER   A OG  1 
ATOM   1027 N N   . LEU   A 1 151 ? 15.15000  -17.31400 -42.77600 1.000 52.31494 ? 347 LEU   A N   1 
ATOM   1028 C CA  . LEU   A 1 151 ? 16.39800  -16.69400 -42.36300 1.000 50.21374 ? 347 LEU   A CA  1 
ATOM   1029 C C   . LEU   A 1 151 ? 17.47000  -17.75700 -42.12100 1.000 53.86201 ? 347 LEU   A C   1 
ATOM   1030 O O   . LEU   A 1 151 ? 17.21100  -18.96300 -42.14100 1.000 56.37005 ? 347 LEU   A O   1 
ATOM   1031 C CB  . LEU   A 1 151 ? 16.18700  -15.86000 -41.09900 1.000 51.79721 ? 347 LEU   A CB  1 
ATOM   1032 C CG  . LEU   A 1 151 ? 15.21700  -14.68100 -41.20000 1.000 49.37078 ? 347 LEU   A CG  1 
ATOM   1033 C CD1 . LEU   A 1 151 ? 14.92300  -14.12100 -39.81800 1.000 50.55550 ? 347 LEU   A CD1 1 
ATOM   1034 C CD2 . LEU   A 1 151 ? 15.77000  -13.59600 -42.11200 1.000 50.32542 ? 347 LEU   A CD2 1 
ATOM   1035 N N   . ARG   A 1 152 ? 18.69300  -17.29000 -41.88500 1.000 53.20281 ? 348 ARG   A N   1 
ATOM   1036 C CA  . ARG   A 1 152 ? 19.80300  -18.18800 -41.60600 1.000 58.61809 ? 348 ARG   A CA  1 
ATOM   1037 C C   . ARG   A 1 152 ? 19.82700  -18.57100 -40.13200 1.000 59.90115 ? 348 ARG   A C   1 
ATOM   1038 O O   . ARG   A 1 152 ? 19.32800  -17.84500 -39.26700 1.000 54.19978 ? 348 ARG   A O   1 
ATOM   1039 C CB  . ARG   A 1 152 ? 21.13500  -17.54400 -42.00100 1.000 50.89387 ? 348 ARG   A CB  1 
ATOM   1040 C CG  . ARG   A 1 152 ? 21.77900  -16.69700 -40.90900 1.000 53.82642 ? 348 ARG   A CG  1 
ATOM   1041 C CD  . ARG   A 1 152 ? 23.29300  -16.65400 -41.06400 1.000 48.53649 ? 348 ARG   A CD  1 
ATOM   1042 N NE  . ARG   A 1 152 ? 23.87600  -15.45100 -40.48100 1.000 50.01852 ? 348 ARG   A NE  1 
ATOM   1043 C CZ  . ARG   A 1 152 ? 24.47500  -15.40300 -39.29900 1.000 50.83065 ? 348 ARG   A CZ  1 
ATOM   1044 N NH1 . ARG   A 1 152 ? 24.58900  -16.47700 -38.53500 1.000 57.68543 ? 348 ARG   A NH1 1 
ATOM   1045 N NH2 . ARG   A 1 152 ? 24.97400  -14.24600 -38.87200 1.000 52.03908 ? 348 ARG   A NH2 1 
ATOM   1046 N N   . LYS   A 1 153 ? 20.41100  -19.73300 -39.85400 1.000 52.51076 ? 349 LYS   A N   1 
ATOM   1047 C CA  . LYS   A 1 153 ? 20.51600  -20.20500 -38.48600 1.000 52.01196 ? 349 LYS   A CA  1 
ATOM   1048 C C   . LYS   A 1 153 ? 21.55100  -19.37600 -37.72400 1.000 54.79007 ? 349 LYS   A C   1 
ATOM   1049 O O   . LYS   A 1 153 ? 22.50200  -18.85900 -38.31800 1.000 61.23163 ? 349 LYS   A O   1 
ATOM   1050 C CB  . LYS   A 1 153 ? 20.89800  -21.68400 -38.46600 1.000 59.26463 ? 349 LYS   A CB  1 
ATOM   1051 C CG  . LYS   A 1 153 ? 20.00800  -22.56000 -39.34200 1.000 58.59426 ? 349 LYS   A CG  1 
ATOM   1052 C CD  . LYS   A 1 153 ? 20.42700  -24.02600 -39.29700 1.000 63.76456 ? 349 LYS   A CD  1 
ATOM   1053 C CE  . LYS   A 1 153 ? 19.82800  -24.74500 -38.09600 1.000 61.54912 ? 349 LYS   A CE  1 
ATOM   1054 N NZ  . LYS   A 1 153 ? 18.41500  -25.15900 -38.33000 1.000 62.15840 ? 349 LYS   A NZ  1 
ATOM   1055 N N   . PRO   A 1 154 ? 21.38700  -19.22500 -36.39900 1.000 53.66574 ? 350 PRO   A N   1 
ATOM   1056 C CA  . PRO   A 1 154 ? 20.31000  -19.78600 -35.57900 1.000 51.14264 ? 350 PRO   A CA  1 
ATOM   1057 C C   . PRO   A 1 154 ? 19.08100  -18.88500 -35.48900 1.000 52.72221 ? 350 PRO   A C   1 
ATOM   1058 O O   . PRO   A 1 154 ? 18.14000  -19.21100 -34.76400 1.000 56.40999 ? 350 PRO   A O   1 
ATOM   1059 C CB  . PRO   A 1 154 ? 20.97300  -19.91900 -34.21300 1.000 52.79110 ? 350 PRO   A CB  1 
ATOM   1060 C CG  . PRO   A 1 154 ? 21.84500  -18.70800 -34.15400 1.000 52.06793 ? 350 PRO   A CG  1 
ATOM   1061 C CD  . PRO   A 1 154 ? 22.38500  -18.53200 -35.56300 1.000 53.59239 ? 350 PRO   A CD  1 
ATOM   1062 N N   . PHE   A 1 155 ? 19.09400  -17.76700 -36.21900 1.000 49.51155 ? 351 PHE   A N   1 
ATOM   1063 C CA  . PHE   A 1 155 ? 18.00400  -16.80100 -36.11600 1.000 50.14559 ? 351 PHE   A CA  1 
ATOM   1064 C C   . PHE   A 1 155 ? 16.67600  -17.37700 -36.59600 1.000 49.25525 ? 351 PHE   A C   1 
ATOM   1065 O O   . PHE   A 1 155 ? 15.61400  -16.96900 -36.11200 1.000 45.00963 ? 351 PHE   A O   1 
ATOM   1066 C CB  . PHE   A 1 155 ? 18.36300  -15.53500 -36.89300 1.000 42.48605 ? 351 PHE   A CB  1 
ATOM   1067 C CG  . PHE   A 1 155 ? 19.59200  -14.84500 -36.37600 1.000 44.22890 ? 351 PHE   A CG  1 
ATOM   1068 C CD1 . PHE   A 1 155 ? 19.53000  -14.06200 -35.23500 1.000 44.12952 ? 351 PHE   A CD1 1 
ATOM   1069 C CD2 . PHE   A 1 155 ? 20.81200  -14.99800 -37.01200 1.000 47.68025 ? 351 PHE   A CD2 1 
ATOM   1070 C CE1 . PHE   A 1 155 ? 20.65900  -13.43000 -34.74700 1.000 48.93526 ? 351 PHE   A CE1 1 
ATOM   1071 C CE2 . PHE   A 1 155 ? 21.94500  -14.36800 -36.53000 1.000 51.61782 ? 351 PHE   A CE2 1 
ATOM   1072 C CZ  . PHE   A 1 155 ? 21.86900  -13.58500 -35.39500 1.000 54.04729 ? 351 PHE   A CZ  1 
ATOM   1073 N N   . CYS   A 1 156 ? 16.70700  -18.32500 -37.52700 1.000 48.42205 ? 352 CYS   A N   1 
ATOM   1074 C CA  . CYS   A 1 156 ? 15.47600  -18.95400 -37.98900 1.000 41.72561 ? 352 CYS   A CA  1 
ATOM   1075 C C   . CYS   A 1 156 ? 14.96200  -20.02000 -37.03000 1.000 43.01217 ? 352 CYS   A C   1 
ATOM   1076 O O   . CYS   A 1 156 ? 13.88500  -20.57700 -37.26600 1.000 42.59506 ? 352 CYS   A O   1 
ATOM   1077 C CB  . CYS   A 1 156 ? 15.68500  -19.57000 -39.37200 1.000 52.33454 ? 352 CYS   A CB  1 
ATOM   1078 S SG  . CYS   A 1 156 ? 16.69500  -21.06600 -39.36300 1.000 57.81457 ? 352 CYS   A SG  1 
ATOM   1079 N N   . ASP   A 1 157 ? 15.70100  -20.31600 -35.96300 1.000 45.45230 ? 353 ASP   A N   1 
ATOM   1080 C CA  . ASP   A 1 157 ? 15.30900  -21.31900 -34.98500 1.000 49.14718 ? 353 ASP   A CA  1 
ATOM   1081 C C   . ASP   A 1 157 ? 14.66000  -20.71200 -33.74700 1.000 49.75063 ? 353 ASP   A C   1 
ATOM   1082 O O   . ASP   A 1 157 ? 14.41200  -21.43100 -32.77500 1.000 52.12571 ? 353 ASP   A O   1 
ATOM   1083 C CB  . ASP   A 1 157 ? 16.52600  -22.14800 -34.57200 1.000 51.47972 ? 353 ASP   A CB  1 
ATOM   1084 C CG  . ASP   A 1 157 ? 17.15100  -22.89200 -35.73600 1.000 56.18368 ? 353 ASP   A CG  1 
ATOM   1085 O OD1 . ASP   A 1 157 ? 18.36100  -23.19300 -35.66400 1.000 55.53596 ? 353 ASP   A OD1 1 
ATOM   1086 O OD2 . ASP   A 1 157 ? 16.43400  -23.18000 -36.71800 1.000 61.22115 ? 353 ASP   A OD2 1 
ATOM   1087 N N   . ILE   A 1 158 ? 14.38200  -19.41300 -33.75600 1.000 50.75757 ? 354 ILE   A N   1 
ATOM   1088 C CA  . ILE   A 1 158 ? 13.94900  -18.72700 -32.54200 1.000 47.69557 ? 354 ILE   A CA  1 
ATOM   1089 C C   . ILE   A 1 158 ? 12.43400  -18.72500 -32.40800 1.000 45.70245 ? 354 ILE   A C   1 
ATOM   1090 O O   . ILE   A 1 158 ? 11.89300  -19.10200 -31.36600 1.000 46.36386 ? 354 ILE   A O   1 
ATOM   1091 C CB  . ILE   A 1 158 ? 14.51700  -17.29200 -32.51500 1.000 48.83503 ? 354 ILE   A CB  1 
ATOM   1092 C CG1 . ILE   A 1 158 ? 16.00200  -17.30200 -32.88700 1.000 47.08666 ? 354 ILE   A CG1 1 
ATOM   1093 C CG2 . ILE   A 1 158 ? 14.29000  -16.65400 -31.14500 1.000 43.75703 ? 354 ILE   A CG2 1 
ATOM   1094 C CD1 . ILE   A 1 158 ? 16.72700  -16.01500 -32.56800 1.000 43.01874 ? 354 ILE   A CD1 1 
ATOM   1095 N N   . MET   A 1 159 ? 11.72300  -18.30700 -33.45000 1.000 37.51981 ? 355 MET   A N   1 
ATOM   1096 C CA  . MET   A 1 159 ? 10.30500  -18.00900 -33.32100 1.000 42.66790 ? 355 MET   A CA  1 
ATOM   1097 C C   . MET   A 1 159 ? 9.41000   -19.22300 -33.51800 1.000 46.47142 ? 355 MET   A C   1 
ATOM   1098 O O   . MET   A 1 159 ? 8.23100   -19.16700 -33.15200 1.000 35.73080 ? 355 MET   A O   1 
ATOM   1099 C CB  . MET   A 1 159 ? 9.91500   -16.91000 -34.31400 1.000 44.77256 ? 355 MET   A CB  1 
ATOM   1100 C CG  . MET   A 1 159 ? 10.45500  -15.54000 -33.92700 1.000 45.81088 ? 355 MET   A CG  1 
ATOM   1101 S SD  . MET   A 1 159 ? 10.05700  -15.05100 -32.23300 1.000 40.71188 ? 355 MET   A SD  1 
ATOM   1102 C CE  . MET   A 1 159 ? 8.29200   -15.33900 -32.20200 1.000 35.71768 ? 355 MET   A CE  1 
ATOM   1103 N N   . GLU   A 1 160 ? 9.93800   -20.31600 -34.06600 1.000 49.71424 ? 356 GLU   A N   1 
ATOM   1104 C CA  . GLU   A 1 160 ? 9.10100   -21.48600 -34.32100 1.000 47.53010 ? 356 GLU   A CA  1 
ATOM   1105 C C   . GLU   A 1 160 ? 8.42500   -22.02300 -33.06400 1.000 32.82141 ? 356 GLU   A C   1 
ATOM   1106 O O   . GLU   A 1 160 ? 7.20000   -22.22900 -33.09600 1.000 36.71459 ? 356 GLU   A O   1 
ATOM   1107 C CB  . GLU   A 1 160 ? 9.92600   -22.57000 -35.02500 1.000 47.83773 ? 356 GLU   A CB  1 
ATOM   1108 C CG  . GLU   A 1 160 ? 9.72600   -22.59600 -36.52900 1.000 52.71642 ? 356 GLU   A CG  1 
ATOM   1109 C CD  . GLU   A 1 160 ? 8.26800   -22.45800 -36.91900 1.000 46.31830 ? 356 GLU   A CD  1 
ATOM   1110 O OE1 . GLU   A 1 160 ? 7.85900   -21.34500 -37.31600 1.000 53.80033 ? 356 GLU   A OE1 1 
ATOM   1111 O OE2 . GLU   A 1 160 ? 7.52800   -23.45700 -36.81900 1.000 51.18189 ? 356 GLU   A OE2 1 
ATOM   1112 N N   . PRO   A 1 161 ? 9.12200   -22.26200 -31.94600 1.000 37.51596 ? 357 PRO   A N   1 
ATOM   1113 C CA  . PRO   A 1 161 ? 8.41400   -22.75500 -30.75300 1.000 35.76720 ? 357 PRO   A CA  1 
ATOM   1114 C C   . PRO   A 1 161 ? 7.42600   -21.75100 -30.17700 1.000 42.39753 ? 357 PRO   A C   1 
ATOM   1115 O O   . PRO   A 1 161 ? 6.47500   -22.16400 -29.50200 1.000 32.55149 ? 357 PRO   A O   1 
ATOM   1116 C CB  . PRO   A 1 161 ? 9.54700   -23.05400 -29.75900 1.000 38.98370 ? 357 PRO   A CB  1 
ATOM   1117 C CG  . PRO   A 1 161 ? 10.80800  -23.03000 -30.55400 1.000 38.47979 ? 357 PRO   A CG  1 
ATOM   1118 C CD  . PRO   A 1 161 ? 10.56400  -22.10100 -31.68800 1.000 40.74890 ? 357 PRO   A CD  1 
ATOM   1119 N N   . LYS   A 1 162 ? 7.61600   -20.45100 -30.41800 1.000 34.43961 ? 358 LYS   A N   1 
ATOM   1120 C CA  . LYS   A 1 162 ? 6.67600   -19.46300 -29.89800 1.000 32.77909 ? 358 LYS   A CA  1 
ATOM   1121 C C   . LYS   A 1 162 ? 5.38300   -19.47000 -30.69800 1.000 32.79620 ? 358 LYS   A C   1 
ATOM   1122 O O   . LYS   A 1 162 ? 4.29000   -19.36300 -30.12600 1.000 35.49899 ? 358 LYS   A O   1 
ATOM   1123 C CB  . LYS   A 1 162 ? 7.30200   -18.06400 -29.90600 1.000 32.21412 ? 358 LYS   A CB  1 
ATOM   1124 C CG  . LYS   A 1 162 ? 8.35400   -17.83300 -28.82700 1.000 32.59442 ? 358 LYS   A CG  1 
ATOM   1125 C CD  . LYS   A 1 162 ? 9.67800   -18.47300 -29.21100 1.000 30.27782 ? 358 LYS   A CD  1 
ATOM   1126 C CE  . LYS   A 1 162 ? 10.71600  -18.35600 -28.11700 1.000 33.24130 ? 358 LYS   A CE  1 
ATOM   1127 N NZ  . LYS   A 1 162 ? 11.97300  -19.05000 -28.51900 1.000 37.76431 ? 358 LYS   A NZ  1 
ATOM   1128 N N   . PHE   A 1 163 ? 5.48400   -19.59500 -32.02400 1.000 34.94857 ? 359 PHE   A N   1 
ATOM   1129 C CA  . PHE   A 1 163 ? 4.28500   -19.72800 -32.84400 1.000 29.70733 ? 359 PHE   A CA  1 
ATOM   1130 C C   . PHE   A 1 163 ? 3.50300   -20.97900 -32.46700 1.000 36.06084 ? 359 PHE   A C   1 
ATOM   1131 O O   . PHE   A 1 163 ? 2.26700   -20.95700 -32.41200 1.000 34.26229 ? 359 PHE   A O   1 
ATOM   1132 C CB  . PHE   A 1 163 ? 4.65700   -19.76500 -34.32800 1.000 43.73315 ? 359 PHE   A CB  1 
ATOM   1133 C CG  . PHE   A 1 163 ? 4.78000   -18.40600 -34.95900 1.000 33.54582 ? 359 PHE   A CG  1 
ATOM   1134 C CD1 . PHE   A 1 163 ? 3.65100   -17.66400 -35.25900 1.000 31.75775 ? 359 PHE   A CD1 1 
ATOM   1135 C CD2 . PHE   A 1 163 ? 6.02500   -17.87800 -35.26100 1.000 43.24113 ? 359 PHE   A CD2 1 
ATOM   1136 C CE1 . PHE   A 1 163 ? 3.75900   -16.41400 -35.84200 1.000 36.47083 ? 359 PHE   A CE1 1 
ATOM   1137 C CE2 . PHE   A 1 163 ? 6.14100   -16.62900 -35.84300 1.000 43.32052 ? 359 PHE   A CE2 1 
ATOM   1138 C CZ  . PHE   A 1 163 ? 5.00500   -15.89700 -36.13300 1.000 39.92589 ? 359 PHE   A CZ  1 
ATOM   1139 N N   . ASP   A 1 164 ? 4.20700   -22.08000 -32.20300 1.000 32.60745 ? 360 ASP   A N   1 
ATOM   1140 C CA  . ASP   A 1 164 ? 3.52800   -23.31000 -31.80500 1.000 32.98477 ? 360 ASP   A CA  1 
ATOM   1141 C C   . ASP   A 1 164 ? 2.83100   -23.14600 -30.46000 1.000 33.23686 ? 360 ASP   A C   1 
ATOM   1142 O O   . ASP   A 1 164 ? 1.68500   -23.58200 -30.29500 1.000 34.79055 ? 360 ASP   A O   1 
ATOM   1143 C CB  . ASP   A 1 164 ? 4.51800   -24.47100 -31.76200 1.000 33.69180 ? 360 ASP   A CB  1 
ATOM   1144 C CG  . ASP   A 1 164 ? 4.91500   -24.94700 -33.14200 1.000 36.53887 ? 360 ASP   A CG  1 
ATOM   1145 O OD1 . ASP   A 1 164 ? 5.95700   -25.62300 -33.25300 1.000 42.99319 ? 360 ASP   A OD1 1 
ATOM   1146 O OD2 . ASP   A 1 164 ? 4.18400   -24.65000 -34.11500 1.000 36.64181 ? 360 ASP   A OD2 1 
ATOM   1147 N N   . PHE   A 1 165 ? 3.49800   -22.51900 -29.48600 1.000 33.86357 ? 361 PHE   A N   1 
ATOM   1148 C CA  . PHE   A 1 165 ? 2.83300   -22.25400 -28.21400 1.000 35.90129 ? 361 PHE   A CA  1 
ATOM   1149 C C   . PHE   A 1 165 ? 1.63600   -21.33500 -28.41300 1.000 31.70451 ? 361 PHE   A C   1 
ATOM   1150 O O   . PHE   A 1 165 ? 0.54800   -21.58700 -27.88400 1.000 32.97327 ? 361 PHE   A O   1 
ATOM   1151 C CB  . PHE   A 1 165 ? 3.80100   -21.64800 -27.19600 1.000 33.63276 ? 361 PHE   A CB  1 
ATOM   1152 C CG  . PHE   A 1 165 ? 3.11100   -21.15700 -25.95000 1.000 27.46861 ? 361 PHE   A CG  1 
ATOM   1153 C CD1 . PHE   A 1 165 ? 2.90100   -22.01700 -24.88400 1.000 34.77081 ? 361 PHE   A CD1 1 
ATOM   1154 C CD2 . PHE   A 1 165 ? 2.64500   -19.85300 -25.85400 1.000 26.63951 ? 361 PHE   A CD2 1 
ATOM   1155 C CE1 . PHE   A 1 165 ? 2.24700   -21.58900 -23.74600 1.000 30.54529 ? 361 PHE   A CE1 1 
ATOM   1156 C CE2 . PHE   A 1 165 ? 1.98800   -19.42100 -24.71800 1.000 30.88192 ? 361 PHE   A CE2 1 
ATOM   1157 C CZ  . PHE   A 1 165 ? 1.78600   -20.29400 -23.66400 1.000 27.83380 ? 361 PHE   A CZ  1 
ATOM   1158 N N   . ALA   A 1 166 ? 1.82500   -20.25500 -29.17700 1.000 34.62995 ? 362 ALA   A N   1 
ATOM   1159 C CA  . ALA   A 1 166 ? 0.75100   -19.29300 -29.38900 1.000 34.32345 ? 362 ALA   A CA  1 
ATOM   1160 C C   . ALA   A 1 166 ? -0.45100  -19.93100 -30.06200 1.000 35.63586 ? 362 ALA   A C   1 
ATOM   1161 O O   . ALA   A 1 166 ? -1.58900  -19.52200 -29.81500 1.000 29.60262 ? 362 ALA   A O   1 
ATOM   1162 C CB  . ALA   A 1 166 ? 1.24900   -18.11800 -30.22900 1.000 34.69410 ? 362 ALA   A CB  1 
ATOM   1163 N N   . MET   A 1 167 ? -0.22200  -20.92800 -30.91500 1.000 35.48405 ? 363 MET   A N   1 
ATOM   1164 C CA  . MET   A 1 167 ? -1.32900  -21.52100 -31.65300 1.000 35.34765 ? 363 MET   A CA  1 
ATOM   1165 C C   . MET   A 1 167 ? -2.26200  -22.27400 -30.71000 1.000 29.77860 ? 363 MET   A C   1 
ATOM   1166 O O   . MET   A 1 167 ? -3.48800  -22.13900 -30.79300 1.000 36.10059 ? 363 MET   A O   1 
ATOM   1167 C CB  . MET   A 1 167 ? -0.78800  -22.44800 -32.74100 1.000 43.04101 ? 363 MET   A CB  1 
ATOM   1168 C CG  . MET   A 1 167 ? -0.39500  -21.77200 -34.06700 1.000 45.82593 ? 363 MET   A CG  1 
ATOM   1169 S SD  . MET   A 1 167 ? -1.31200  -20.31600 -34.62100 1.000 44.63836 ? 363 MET   A SD  1 
ATOM   1170 C CE  . MET   A 1 167 ? -0.50200  -18.97100 -33.74000 1.000 44.66461 ? 363 MET   A CE  1 
ATOM   1171 N N   . LYS   A 1 168 ? -1.69700  -23.05900 -29.79500 1.000 35.55449 ? 364 LYS   A N   1 
ATOM   1172 C CA  . LYS   A 1 168 ? -2.51900  -23.76900 -28.82300 1.000 38.37901 ? 364 LYS   A CA  1 
ATOM   1173 C C   . LYS   A 1 168 ? -3.03200  -22.84100 -27.72800 1.000 41.13813 ? 364 LYS   A C   1 
ATOM   1174 O O   . LYS   A 1 168 ? -4.13700  -23.04600 -27.21600 1.000 36.51802 ? 364 LYS   A O   1 
ATOM   1175 C CB  . LYS   A 1 168 ? -1.72900  -24.93500 -28.22500 1.000 37.29646 ? 364 LYS   A CB  1 
ATOM   1176 C CG  . LYS   A 1 168 ? -1.53500  -26.09300 -29.20800 1.000 40.88095 ? 364 LYS   A CG  1 
ATOM   1177 C CD  . LYS   A 1 168 ? -0.78600  -27.26400 -28.59000 1.000 41.73089 ? 364 LYS   A CD  1 
ATOM   1178 C CE  . LYS   A 1 168 ? 0.59900   -26.86300 -28.10000 1.000 44.31364 ? 364 LYS   A CE  1 
ATOM   1179 N NZ  . LYS   A 1 168 ? 1.25000   -27.96800 -27.33600 1.000 50.95070 ? 364 LYS   A NZ  1 
ATOM   1180 N N   . PHE   A 1 169 ? -2.26100  -21.81000 -27.37200 1.000 35.88913 ? 365 PHE   A N   1 
ATOM   1181 C CA  . PHE   A 1 169 ? -2.73900  -20.84100 -26.39000 1.000 36.28985 ? 365 PHE   A CA  1 
ATOM   1182 C C   . PHE   A 1 169 ? -3.90800  -20.03400 -26.94100 1.000 33.38236 ? 365 PHE   A C   1 
ATOM   1183 O O   . PHE   A 1 169 ? -4.88800  -19.78500 -26.22900 1.000 32.99835 ? 365 PHE   A O   1 
ATOM   1184 C CB  . PHE   A 1 169 ? -1.59100  -19.92300 -25.96800 1.000 30.69690 ? 365 PHE   A CB  1 
ATOM   1185 C CG  . PHE   A 1 169 ? -1.89400  -19.07400 -24.76200 1.000 31.00610 ? 365 PHE   A CG  1 
ATOM   1186 C CD1 . PHE   A 1 169 ? -1.83200  -19.61300 -23.48600 1.000 33.43541 ? 365 PHE   A CD1 1 
ATOM   1187 C CD2 . PHE   A 1 169 ? -2.22000  -17.73100 -24.90300 1.000 28.03717 ? 365 PHE   A CD2 1 
ATOM   1188 C CE1 . PHE   A 1 169 ? -2.10100  -18.83100 -22.37100 1.000 28.13348 ? 365 PHE   A CE1 1 
ATOM   1189 C CE2 . PHE   A 1 169 ? -2.48800  -16.94300 -23.79200 1.000 26.91238 ? 365 PHE   A CE2 1 
ATOM   1190 C CZ  . PHE   A 1 169 ? -2.42900  -17.49800 -22.52300 1.000 22.66449 ? 365 PHE   A CZ  1 
ATOM   1191 N N   . ASN   A 1 170 ? -3.83200  -19.63000 -28.21300 1.000 31.04661 ? 366 ASN   A N   1 
ATOM   1192 C CA  . ASN   A 1 170 ? -4.91600  -18.85800 -28.81200 1.000 28.32479 ? 366 ASN   A CA  1 
ATOM   1193 C C   . ASN   A 1 170 ? -6.18600  -19.68600 -28.96900 1.000 31.46642 ? 366 ASN   A C   1 
ATOM   1194 O O   . ASN   A 1 170 ? -7.28900  -19.12500 -28.99100 1.000 33.05409 ? 366 ASN   A O   1 
ATOM   1195 C CB  . ASN   A 1 170 ? -4.48100  -18.30300 -30.16900 1.000 30.66629 ? 366 ASN   A CB  1 
ATOM   1196 C CG  . ASN   A 1 170 ? -3.64400  -17.03900 -30.04400 1.000 35.91481 ? 366 ASN   A CG  1 
ATOM   1197 O OD1 . ASN   A 1 170 ? -3.41400  -16.54000 -28.94200 1.000 29.75943 ? 366 ASN   A OD1 1 
ATOM   1198 N ND2 . ASN   A 1 170 ? -3.18000  -16.52000 -31.17600 1.000 30.83085 ? 366 ASN   A ND2 1 
ATOM   1199 N N   . ALA   A 1 171 ? -6.06000  -21.01100 -29.08000 1.000 36.75658 ? 367 ALA   A N   1 
ATOM   1200 C CA  . ALA   A 1 171 ? -7.24400  -21.85400 -29.20900 1.000 36.35301 ? 367 ALA   A CA  1 
ATOM   1201 C C   . ALA   A 1 171 ? -8.11700  -21.81500 -27.96300 1.000 42.53066 ? 367 ALA   A C   1 
ATOM   1202 O O   . ALA   A 1 171 ? -9.31700  -22.09600 -28.05200 1.000 44.16328 ? 367 ALA   A O   1 
ATOM   1203 C CB  . ALA   A 1 171 ? -6.83900  -23.29600 -29.51700 1.000 30.11855 ? 367 ALA   A CB  1 
ATOM   1204 N N   . LEU   A 1 172 ? -7.54600  -21.46600 -26.80700 1.000 36.78634 ? 368 LEU   A N   1 
ATOM   1205 C CA  . LEU   A 1 172 ? -8.33300  -21.30800 -25.59000 1.000 35.10459 ? 368 LEU   A CA  1 
ATOM   1206 C C   . LEU   A 1 172 ? -9.24300  -20.08900 -25.63700 1.000 36.58607 ? 368 LEU   A C   1 
ATOM   1207 O O   . LEU   A 1 172 ? -10.14000 -19.97800 -24.79500 1.000 39.71926 ? 368 LEU   A O   1 
ATOM   1208 C CB  . LEU   A 1 172 ? -7.40800  -21.21700 -24.37500 1.000 25.76634 ? 368 LEU   A CB  1 
ATOM   1209 C CG  . LEU   A 1 172 ? -6.39000  -22.33800 -24.17900 1.000 38.04704 ? 368 LEU   A CG  1 
ATOM   1210 C CD1 . LEU   A 1 172 ? -5.47100  -22.02000 -23.01400 1.000 36.83721 ? 368 LEU   A CD1 1 
ATOM   1211 C CD2 . LEU   A 1 172 ? -7.09900  -23.65400 -23.94700 1.000 34.98629 ? 368 LEU   A CD2 1 
ATOM   1212 N N   . GLU   A 1 173 ? -9.02300  -19.17600 -26.58500 1.000 29.29985 ? 369 GLU   A N   1 
ATOM   1213 C CA  . GLU   A 1 173 ? -9.90000  -18.02500 -26.80500 1.000 37.73442 ? 369 GLU   A CA  1 
ATOM   1214 C C   . GLU   A 1 173 ? -10.03100 -17.16000 -25.55200 1.000 31.15402 ? 369 GLU   A C   1 
ATOM   1215 O O   . GLU   A 1 173 ? -11.11600 -16.67900 -25.22100 1.000 29.93544 ? 369 GLU   A O   1 
ATOM   1216 C CB  . GLU   A 1 173 ? -11.27700 -18.46600 -27.30800 1.000 47.59020 ? 369 GLU   A CB  1 
ATOM   1217 C CG  . GLU   A 1 173 ? -11.22900 -19.48500 -28.43600 1.000 48.10137 ? 369 GLU   A CG  1 
ATOM   1218 C CD  . GLU   A 1 173 ? -11.01600 -18.83400 -29.78800 1.000 59.24814 ? 369 GLU   A CD  1 
ATOM   1219 O OE1 . GLU   A 1 173 ? -11.37500 -17.64600 -29.93600 1.000 58.68816 ? 369 GLU   A OE1 1 
ATOM   1220 O OE2 . GLU   A 1 173 ? -10.49400 -19.50700 -30.70300 1.000 62.04659 ? 369 GLU   A OE2 1 
ATOM   1221 N N   . LEU   A 1 174 ? -8.92000  -16.96500 -24.84600 1.000 30.56305 ? 370 LEU   A N   1 
ATOM   1222 C CA  . LEU   A 1 174 ? -8.91200  -16.01600 -23.74200 1.000 24.55116 ? 370 LEU   A CA  1 
ATOM   1223 C C   . LEU   A 1 174 ? -9.08300  -14.59700 -24.27200 1.000 30.68706 ? 370 LEU   A C   1 
ATOM   1224 O O   . LEU   A 1 174 ? -8.73500  -14.29600 -25.41700 1.000 31.96364 ? 370 LEU   A O   1 
ATOM   1225 C CB  . LEU   A 1 174 ? -7.60800  -16.12700 -22.94800 1.000 24.33978 ? 370 LEU   A CB  1 
ATOM   1226 C CG  . LEU   A 1 174 ? -7.22000  -17.52000 -22.45000 1.000 27.03766 ? 370 LEU   A CG  1 
ATOM   1227 C CD1 . LEU   A 1 174 ? -5.94600  -17.45700 -21.62400 1.000 28.51368 ? 370 LEU   A CD1 1 
ATOM   1228 C CD2 . LEU   A 1 174 ? -8.35200  -18.13100 -21.64300 1.000 29.56017 ? 370 LEU   A CD2 1 
ATOM   1229 N N   . ASP   A 1 175 ? -9.64400  -13.72100 -23.43500 1.000 27.32798 ? 371 ASP   A N   1 
ATOM   1230 C CA  . ASP   A 1 175 ? -9.66800  -12.29300 -23.72600 1.000 29.36545 ? 371 ASP   A CA  1 
ATOM   1231 C C   . ASP   A 1 175 ? -8.69000  -11.56900 -22.80600 1.000 30.23731 ? 371 ASP   A C   1 
ATOM   1232 O O   . ASP   A 1 175 ? -8.06000  -12.16800 -21.93100 1.000 28.85070 ? 371 ASP   A O   1 
ATOM   1233 C CB  . ASP   A 1 175 ? -11.08700 -11.71600 -23.61400 1.000 32.80153 ? 371 ASP   A CB  1 
ATOM   1234 C CG  . ASP   A 1 175 ? -11.73200 -11.95400 -22.25700 1.000 37.00965 ? 371 ASP   A CG  1 
ATOM   1235 O OD1 . ASP   A 1 175 ? -11.04200 -11.87900 -21.21800 1.000 34.48445 ? 371 ASP   A OD1 1 
ATOM   1236 O OD2 . ASP   A 1 175 ? -12.95600 -12.20900 -22.23500 1.000 38.83018 ? 371 ASP   A OD2 1 
ATOM   1237 N N   . ASP   A 1 176 ? -8.57000  -10.25500 -23.01100 1.000 28.34691 ? 372 ASP   A N   1 
ATOM   1238 C CA  . ASP   A 1 176 ? -7.62400  -9.46900  -22.22600 1.000 25.59580 ? 372 ASP   A CA  1 
ATOM   1239 C C   . ASP   A 1 176 ? -7.91500  -9.55300  -20.73300 1.000 28.15011 ? 372 ASP   A C   1 
ATOM   1240 O O   . ASP   A 1 176 ? -6.98800  -9.46600  -19.91900 1.000 26.77374 ? 372 ASP   A O   1 
ATOM   1241 C CB  . ASP   A 1 176 ? -7.64200  -8.01300  -22.69100 1.000 31.18260 ? 372 ASP   A CB  1 
ATOM   1242 C CG  . ASP   A 1 176 ? -6.99700  -7.83000  -24.05400 1.000 33.81429 ? 372 ASP   A CG  1 
ATOM   1243 O OD1 . ASP   A 1 176 ? -5.80600  -8.17700  -24.19800 1.000 32.44190 ? 372 ASP   A OD1 1 
ATOM   1244 O OD2 . ASP   A 1 176 ? -7.68200  -7.34800  -24.98300 1.000 37.46003 ? 372 ASP   A OD2 1 
ATOM   1245 N N   . SER   A 1 177 ? -9.18300  -9.73000  -20.34900 1.000 29.37957 ? 373 SER   A N   1 
ATOM   1246 C CA  . SER   A 1 177 ? -9.49300  -9.86900  -18.92800 1.000 27.19585 ? 373 SER   A CA  1 
ATOM   1247 C C   . SER   A 1 177 ? -8.92700  -11.17100 -18.37000 1.000 28.10730 ? 373 SER   A C   1 
ATOM   1248 O O   . SER   A 1 177 ? -8.39400  -11.19000 -17.25200 1.000 29.06277 ? 373 SER   A O   1 
ATOM   1249 C CB  . SER   A 1 177 ? -11.00800 -9.76500  -18.69400 1.000 22.93309 ? 373 SER   A CB  1 
ATOM   1250 O OG  . SER   A 1 177 ? -11.72000 -10.91100 -19.13600 1.000 23.31449 ? 373 SER   A OG  1 
ATOM   1251 N N   . ASP   A 1 178 ? -8.99900  -12.26100 -19.14400 1.000 23.16778 ? 374 ASP   A N   1 
ATOM   1252 C CA  . ASP   A 1 178 ? -8.37000  -13.51500 -18.72800 1.000 22.68696 ? 374 ASP   A CA  1 
ATOM   1253 C C   . ASP   A 1 178 ? -6.85100  -13.38100 -18.69500 1.000 21.66847 ? 374 ASP   A C   1 
ATOM   1254 O O   . ASP   A 1 178 ? -6.19300  -13.83700 -17.75200 1.000 19.79937 ? 374 ASP   A O   1 
ATOM   1255 C CB  . ASP   A 1 178 ? -8.75600  -14.65500 -19.67600 1.000 22.88944 ? 374 ASP   A CB  1 
ATOM   1256 C CG  . ASP   A 1 178 ? -10.25500 -14.77200 -19.90000 1.000 32.48214 ? 374 ASP   A CG  1 
ATOM   1257 O OD1 . ASP   A 1 178 ? -10.66300 -14.96600 -21.06800 1.000 28.47113 ? 374 ASP   A OD1 1 
ATOM   1258 O OD2 . ASP   A 1 178 ? -11.01900 -14.70300 -18.91600 1.000 30.31120 ? 374 ASP   A OD2 1 
ATOM   1259 N N   . ILE   A 1 179 ? -6.28100  -12.77000 -19.73500 1.000 21.00954 ? 375 ILE   A N   1 
ATOM   1260 C CA  . ILE   A 1 179 ? -4.83000  -12.71600 -19.88800 1.000 23.70930 ? 375 ILE   A CA  1 
ATOM   1261 C C   . ILE   A 1 179 ? -4.20100  -11.86700 -18.79200 1.000 21.92110 ? 375 ILE   A C   1 
ATOM   1262 O O   . ILE   A 1 179 ? -3.12100  -12.19300 -18.28500 1.000 19.60635 ? 375 ILE   A O   1 
ATOM   1263 C CB  . ILE   A 1 179 ? -4.47100  -12.19800 -21.29300 1.000 22.42934 ? 375 ILE   A CB  1 
ATOM   1264 C CG1 . ILE   A 1 179 ? -4.94400  -13.19300 -22.35700 1.000 24.20327 ? 375 ILE   A CG1 1 
ATOM   1265 C CG2 . ILE   A 1 179 ? -2.96500  -11.93500 -21.41500 1.000 23.50599 ? 375 ILE   A CG2 1 
ATOM   1266 C CD1 . ILE   A 1 179 ? -5.01000  -12.60000 -23.74800 1.000 31.19123 ? 375 ILE   A CD1 1 
ATOM   1267 N N   . SER   A 1 180 ? -4.86900  -10.77700 -18.39700 1.000 21.75647 ? 376 SER   A N   1 
ATOM   1268 C CA  . SER   A 1 180 ? -4.33400  -9.91400  -17.34700 1.000 21.98100 ? 376 SER   A CA  1 
ATOM   1269 C C   . SER   A 1 180 ? -4.10900  -10.68800 -16.05200 1.000 24.41265 ? 376 SER   A C   1 
ATOM   1270 O O   . SER   A 1 180 ? -3.06600  -10.54900 -15.40400 1.000 19.99881 ? 376 SER   A O   1 
ATOM   1271 C CB  . SER   A 1 180 ? -5.27200  -8.72900  -17.10900 1.000 23.63436 ? 376 SER   A CB  1 
ATOM   1272 O OG  . SER   A 1 180 ? -6.46300  -9.13600  -16.46000 1.000 25.60871 ? 376 SER   A OG  1 
ATOM   1273 N N   . LEU   A 1 181 ? -5.07900  -11.51300 -15.65800 1.000 19.73618 ? 377 LEU   A N   1 
ATOM   1274 C CA  . LEU   A 1 181 ? -4.91700  -12.30800 -14.44400 1.000 17.97449 ? 377 LEU   A CA  1 
ATOM   1275 C C   . LEU   A 1 181 ? -3.87400  -13.40100 -14.63700 1.000 20.31864 ? 377 LEU   A C   1 
ATOM   1276 O O   . LEU   A 1 181 ? -3.14700  -13.74600 -13.69900 1.000 20.79875 ? 377 LEU   A O   1 
ATOM   1277 C CB  . LEU   A 1 181 ? -6.25600  -12.91700 -14.03700 1.000 21.85854 ? 377 LEU   A CB  1 
ATOM   1278 C CG  . LEU   A 1 181 ? -7.31700  -11.91800 -13.57900 1.000 24.89033 ? 377 LEU   A CG  1 
ATOM   1279 C CD1 . LEU   A 1 181 ? -8.65800  -12.62900 -13.38400 1.000 23.96649 ? 377 LEU   A CD1 1 
ATOM   1280 C CD2 . LEU   A 1 181 ? -6.88700  -11.21200 -12.29900 1.000 27.53353 ? 377 LEU   A CD2 1 
ATOM   1281 N N   . PHE   A 1 182 ? -3.80200  -13.96600 -15.84300 1.000 17.41462 ? 378 PHE   A N   1 
ATOM   1282 C CA  . PHE   A 1 182 ? -2.80300  -14.98700 -16.14100 1.000 18.94560 ? 378 PHE   A CA  1 
ATOM   1283 C C   . PHE   A 1 182 ? -1.39200  -14.43300 -15.98100 1.000 20.74563 ? 378 PHE   A C   1 
ATOM   1284 O O   . PHE   A 1 182 ? -0.51900  -15.07100 -15.37800 1.000 19.87868 ? 378 PHE   A O   1 
ATOM   1285 C CB  . PHE   A 1 182 ? -3.02500  -15.50800 -17.56200 1.000 17.84895 ? 378 PHE   A CB  1 
ATOM   1286 C CG  . PHE   A 1 182 ? -2.13400  -16.66600 -17.94300 1.000 20.35475 ? 378 PHE   A CG  1 
ATOM   1287 C CD1 . PHE   A 1 182 ? -2.32200  -17.91500 -17.37900 1.000 23.22191 ? 378 PHE   A CD1 1 
ATOM   1288 C CD2 . PHE   A 1 182 ? -1.13800  -16.50700 -18.89000 1.000 24.30545 ? 378 PHE   A CD2 1 
ATOM   1289 C CE1 . PHE   A 1 182 ? -1.51900  -18.98500 -17.73900 1.000 32.26901 ? 378 PHE   A CE1 1 
ATOM   1290 C CE2 . PHE   A 1 182 ? -0.32800  -17.57600 -19.25800 1.000 23.92310 ? 378 PHE   A CE2 1 
ATOM   1291 C CZ  . PHE   A 1 182 ? -0.52100  -18.81300 -18.67900 1.000 21.30757 ? 378 PHE   A CZ  1 
ATOM   1292 N N   . VAL   A 1 183 ? -1.15300  -13.23400 -16.51400 1.000 23.33469 ? 379 VAL   A N   1 
ATOM   1293 C CA  . VAL   A 1 183 ? 0.16700   -12.62200 -16.41800 1.000 20.58933 ? 379 VAL   A CA  1 
ATOM   1294 C C   . VAL   A 1 183 ? 0.48800   -12.25700 -14.97300 1.000 24.17048 ? 379 VAL   A C   1 
ATOM   1295 O O   . VAL   A 1 183 ? 1.62400   -12.42500 -14.51500 1.000 22.21108 ? 379 VAL   A O   1 
ATOM   1296 C CB  . VAL   A 1 183 ? 0.24800   -11.40300 -17.35500 1.000 21.74490 ? 379 VAL   A CB  1 
ATOM   1297 C CG1 . VAL   A 1 183 ? 1.53000   -10.60400 -17.11700 1.000 22.97076 ? 379 VAL   A CG1 1 
ATOM   1298 C CG2 . VAL   A 1 183 ? 0.16900   -11.86000 -18.80100 1.000 24.25177 ? 379 VAL   A CG2 1 
ATOM   1299 N N   . ALA   A 1 184 ? -0.50400  -11.76800 -14.22700 1.000 23.50910 ? 380 ALA   A N   1 
ATOM   1300 C CA  . ALA   A 1 184 ? -0.29000  -11.50200 -12.80600 1.000 22.71113 ? 380 ALA   A CA  1 
ATOM   1301 C C   . ALA   A 1 184 ? 0.12800   -12.76600 -12.05900 1.000 24.37757 ? 380 ALA   A C   1 
ATOM   1302 O O   . ALA   A 1 184 ? 1.03300   -12.72500 -11.21700 1.000 27.58273 ? 380 ALA   A O   1 
ATOM   1303 C CB  . ALA   A 1 184 ? -1.55400  -10.90300 -12.18500 1.000 21.44929 ? 380 ALA   A CB  1 
ATOM   1304 N N   . ALA   A 1 185 ? -0.52100  -13.90000 -12.34900 1.000 22.49511 ? 381 ALA   A N   1 
ATOM   1305 C CA  . ALA   A 1 185 ? -0.13800  -15.15700 -11.71000 1.000 20.89447 ? 381 ALA   A CA  1 
ATOM   1306 C C   . ALA   A 1 185 ? 1.26100   -15.59600 -12.12400 1.000 26.87593 ? 381 ALA   A C   1 
ATOM   1307 O O   . ALA   A 1 185 ? 1.98300   -16.20400 -11.32500 1.000 23.55705 ? 381 ALA   A O   1 
ATOM   1308 C CB  . ALA   A 1 185 ? -1.14700  -16.25300 -12.04600 1.000 21.36126 ? 381 ALA   A CB  1 
ATOM   1309 N N   . ILE   A 1 186 ? 1.65500   -15.30600 -13.36400 1.000 25.70552 ? 382 ILE   A N   1 
ATOM   1310 C CA  . ILE   A 1 186 ? 3.00500   -15.63600 -13.81600 1.000 26.90981 ? 382 ILE   A CA  1 
ATOM   1311 C C   . ILE   A 1 186 ? 4.04000   -14.86800 -13.00000 1.000 26.46894 ? 382 ILE   A C   1 
ATOM   1312 O O   . ILE   A 1 186 ? 5.03700   -15.43100 -12.53200 1.000 27.46510 ? 382 ILE   A O   1 
ATOM   1313 C CB  . ILE   A 1 186 ? 3.14500   -15.34400 -15.32100 1.000 24.18069 ? 382 ILE   A CB  1 
ATOM   1314 C CG1 . ILE   A 1 186 ? 2.50000   -16.45600 -16.14500 1.000 22.17052 ? 382 ILE   A CG1 1 
ATOM   1315 C CG2 . ILE   A 1 186 ? 4.60800   -15.17600 -15.70300 1.000 24.75606 ? 382 ILE   A CG2 1 
ATOM   1316 C CD1 . ILE   A 1 186 ? 2.31200   -16.07400 -17.60100 1.000 21.87752 ? 382 ILE   A CD1 1 
ATOM   1317 N N   . ILE   A 1 187 ? 3.81100   -13.56900 -12.80800 1.000 26.92837 ? 383 ILE   A N   1 
ATOM   1318 C CA  . ILE   A 1 187 ? 4.79000   -12.73100 -12.12200 1.000 25.38819 ? 383 ILE   A CA  1 
ATOM   1319 C C   . ILE   A 1 187 ? 4.88600   -13.10700 -10.64700 1.000 34.40217 ? 383 ILE   A C   1 
ATOM   1320 O O   . ILE   A 1 187 ? 5.98300   -13.25400 -10.09500 1.000 28.74395 ? 383 ILE   A O   1 
ATOM   1321 C CB  . ILE   A 1 187 ? 4.43800   -11.24500 -12.30400 1.000 30.42905 ? 383 ILE   A CB  1 
ATOM   1322 C CG1 . ILE   A 1 187 ? 4.64600   -10.83100 -13.76100 1.000 27.41226 ? 383 ILE   A CG1 1 
ATOM   1323 C CG2 . ILE   A 1 187 ? 5.27100   -10.37300 -11.37000 1.000 29.59503 ? 383 ILE   A CG2 1 
ATOM   1324 C CD1 . ILE   A 1 187 ? 3.94300   -9.54700  -14.13200 1.000 32.33202 ? 383 ILE   A CD1 1 
ATOM   1325 N N   . CYS   A 1 188 ? 3.74100   -13.27300 -9.98600  1.000 26.17451 ? 384 CYS   A N   1 
ATOM   1326 C CA  . CYS   A 1 188 ? 3.71800   -13.50800 -8.54300  1.000 25.69067 ? 384 CYS   A CA  1 
ATOM   1327 C C   . CYS   A 1 188 ? 3.88200   -14.99800 -8.23200  1.000 33.36457 ? 384 CYS   A C   1 
ATOM   1328 O O   . CYS   A 1 188 ? 3.06200   -15.62500 -7.57000  1.000 44.34918 ? 384 CYS   A O   1 
ATOM   1329 C CB  . CYS   A 1 188 ? 2.43200   -12.95300 -7.94600  1.000 33.25734 ? 384 CYS   A CB  1 
ATOM   1330 S SG  . CYS   A 1 188 ? 2.22700   -11.18800 -8.22100  1.000 38.06727 ? 384 CYS   A SG  1 
ATOM   1331 N N   . CYS   A 1 189 ? 4.98500   -15.55400 -8.71200  1.000 39.86312 ? 385 CYS   A N   1 
ATOM   1332 C CA  . CYS   A 1 189 ? 5.27800   -16.97300 -8.57600  1.000 33.58414 ? 385 CYS   A CA  1 
ATOM   1333 C C   . CYS   A 1 189 ? 6.23600   -17.18400 -7.40800  1.000 32.07573 ? 385 CYS   A C   1 
ATOM   1334 O O   . CYS   A 1 189 ? 7.36300   -16.67900 -7.42900  1.000 32.11649 ? 385 CYS   A O   1 
ATOM   1335 C CB  . CYS   A 1 189 ? 5.88000   -17.50900 -9.87300  1.000 35.24136 ? 385 CYS   A CB  1 
ATOM   1336 S SG  . CYS   A 1 189 ? 6.19800   -19.26600 -9.85200  1.000 45.91984 ? 385 CYS   A SG  1 
ATOM   1337 N N   . GLY   A 1 190 ? 5.78900   -17.92500 -6.39300  1.000 32.55638 ? 386 GLY   A N   1 
ATOM   1338 C CA  . GLY   A 1 190 ? 6.59700   -18.16900 -5.21400  1.000 30.20445 ? 386 GLY   A CA  1 
ATOM   1339 C C   . GLY   A 1 190 ? 7.67200   -19.21500 -5.37600  1.000 37.01424 ? 386 GLY   A C   1 
ATOM   1340 O O   . GLY   A 1 190 ? 8.39600   -19.51300 -4.42200  1.000 39.51020 ? 386 GLY   A O   1 
ATOM   1341 N N   . ASP   A 1 191 ? 7.80100   -19.76800 -6.57700  1.000 37.00570 ? 387 ASP   A N   1 
ATOM   1342 C CA  . ASP   A 1 191 ? 8.71100   -20.85900 -6.88800  1.000 41.90319 ? 387 ASP   A CA  1 
ATOM   1343 C C   . ASP   A 1 191 ? 10.06200  -20.37300 -7.40400  1.000 38.03504 ? 387 ASP   A C   1 
ATOM   1344 O O   . ASP   A 1 191 ? 10.96800  -21.19000 -7.60100  1.000 42.16605 ? 387 ASP   A O   1 
ATOM   1345 C CB  . ASP   A 1 191 ? 8.05300   -21.77400 -7.93000  1.000 43.01445 ? 387 ASP   A CB  1 
ATOM   1346 C CG  . ASP   A 1 191 ? 8.69200   -23.14300 -8.00800  1.000 60.71493 ? 387 ASP   A CG  1 
ATOM   1347 O OD1 . ASP   A 1 191 ? 9.53700   -23.46900 -7.14900  1.000 63.64701 ? 387 ASP   A OD1 1 
ATOM   1348 O OD2 . ASP   A 1 191 ? 8.34200   -23.89700 -8.94200  1.000 64.02191 ? 387 ASP   A OD2 1 
ATOM   1349 N N   . ARG   A 1 192 ? 10.22300  -19.07100 -7.61600  1.000 32.79021 ? 388 ARG   A N   1 
ATOM   1350 C CA  . ARG   A 1 192 ? 11.41500  -18.56600 -8.27900  1.000 38.31174 ? 388 ARG   A CA  1 
ATOM   1351 C C   . ARG   A 1 192 ? 12.65000  -18.73600 -7.39300  1.000 38.50954 ? 388 ARG   A C   1 
ATOM   1352 O O   . ARG   A 1 192 ? 12.56900  -18.62700 -6.16600  1.000 45.77455 ? 388 ARG   A O   1 
ATOM   1353 C CB  . ARG   A 1 192 ? 11.23800  -17.09700 -8.65300  1.000 35.99893 ? 388 ARG   A CB  1 
ATOM   1354 C CG  . ARG   A 1 192 ? 9.92700   -16.79300 -9.36500  1.000 33.56693 ? 388 ARG   A CG  1 
ATOM   1355 C CD  . ARG   A 1 192 ? 9.82500   -17.56600 -10.67200 1.000 33.40155 ? 388 ARG   A CD  1 
ATOM   1356 N NE  . ARG   A 1 192 ? 8.86300   -16.97100 -11.59300 1.000 26.71400 ? 388 ARG   A NE  1 
ATOM   1357 C CZ  . ARG   A 1 192 ? 8.51200   -17.50300 -12.75500 1.000 33.55276 ? 388 ARG   A CZ  1 
ATOM   1358 N NH1 . ARG   A 1 192 ? 9.03500   -18.64300 -13.18100 1.000 28.42595 ? 388 ARG   A NH1 1 
ATOM   1359 N NH2 . ARG   A 1 192 ? 7.61100   -16.88000 -13.50800 1.000 28.19152 ? 388 ARG   A NH2 1 
ATOM   1360 N N   . PRO   A 1 193 ? 13.80500  -19.01400 -7.99500  1.000 40.34393 ? 389 PRO   A N   1 
ATOM   1361 C CA  . PRO   A 1 193 ? 15.02100  -19.20900 -7.19800  1.000 39.70675 ? 389 PRO   A CA  1 
ATOM   1362 C C   . PRO   A 1 193 ? 15.45400  -17.92300 -6.51300  1.000 35.87465 ? 389 PRO   A C   1 
ATOM   1363 O O   . PRO   A 1 193 ? 15.46100  -16.84700 -7.11500  1.000 39.26776 ? 389 PRO   A O   1 
ATOM   1364 C CB  . PRO   A 1 193 ? 16.05700  -19.66500 -8.23400  1.000 45.76095 ? 389 PRO   A CB  1 
ATOM   1365 C CG  . PRO   A 1 193 ? 15.26100  -20.10200 -9.42500  1.000 38.99234 ? 389 PRO   A CG  1 
ATOM   1366 C CD  . PRO   A 1 193 ? 14.04400  -19.23700 -9.43000  1.000 38.96270 ? 389 PRO   A CD  1 
ATOM   1367 N N   . GLY   A 1 194 ? 15.82200  -18.04500 -5.24200  1.000 41.68015 ? 390 GLY   A N   1 
ATOM   1368 C CA  . GLY   A 1 194 ? 16.35300  -16.92000 -4.50300  1.000 35.48617 ? 390 GLY   A CA  1 
ATOM   1369 C C   . GLY   A 1 194 ? 15.33000  -16.03400 -3.83300  1.000 44.07827 ? 390 GLY   A C   1 
ATOM   1370 O O   . GLY   A 1 194 ? 15.70900  -14.99800 -3.27300  1.000 39.25117 ? 390 GLY   A O   1 
ATOM   1371 N N   . LEU   A 1 195 ? 14.05200  -16.40000 -3.86800  1.000 37.10694 ? 391 LEU   A N   1 
ATOM   1372 C CA  . LEU   A 1 195 ? 13.02700  -15.57700 -3.24200  1.000 39.59514 ? 391 LEU   A CA  1 
ATOM   1373 C C   . LEU   A 1 195 ? 13.17100  -15.60700 -1.72600  1.000 38.64547 ? 391 LEU   A C   1 
ATOM   1374 O O   . LEU   A 1 195 ? 13.46200  -16.65000 -1.13500  1.000 45.29667 ? 391 LEU   A O   1 
ATOM   1375 C CB  . LEU   A 1 195 ? 11.63400  -16.06000 -3.64200  1.000 35.87512 ? 391 LEU   A CB  1 
ATOM   1376 C CG  . LEU   A 1 195 ? 11.13900  -15.62100 -5.02000  1.000 38.87822 ? 391 LEU   A CG  1 
ATOM   1377 C CD1 . LEU   A 1 195 ? 9.78400   -16.24900 -5.32700  1.000 38.56583 ? 391 LEU   A CD1 1 
ATOM   1378 C CD2 . LEU   A 1 195 ? 11.06900  -14.10900 -5.10800  1.000 26.83298 ? 391 LEU   A CD2 1 
ATOM   1379 N N   . LEU   A 1 196 ? 12.96300  -14.44900 -1.09600  1.000 39.80081 ? 392 LEU   A N   1 
ATOM   1380 C CA  . LEU   A 1 196 ? 13.02300  -14.36800 0.36400   1.000 43.21132 ? 392 LEU   A CA  1 
ATOM   1381 C C   . LEU   A 1 196 ? 11.68800  -14.76000 0.99300   1.000 38.55345 ? 392 LEU   A C   1 
ATOM   1382 O O   . LEU   A 1 196 ? 11.56800  -15.82000 1.61300   1.000 42.95509 ? 392 LEU   A O   1 
ATOM   1383 C CB  . LEU   A 1 196 ? 13.44800  -12.96100 0.79900   1.000 42.76940 ? 392 LEU   A CB  1 
ATOM   1384 C CG  . LEU   A 1 196 ? 14.90600  -12.57700 0.54100   1.000 41.84731 ? 392 LEU   A CG  1 
ATOM   1385 C CD1 . LEU   A 1 196 ? 15.21700  -11.22000 1.15500   1.000 41.62355 ? 392 LEU   A CD1 1 
ATOM   1386 C CD2 . LEU   A 1 196 ? 15.84700  -13.64300 1.08700   1.000 40.10657 ? 392 LEU   A CD2 1 
ATOM   1387 N N   . ASN   A 1 197 ? 10.66700  -13.91800 0.84100   1.000 42.16250 ? 393 ASN   A N   1 
ATOM   1388 C CA  . ASN   A 1 197 ? 9.37700   -14.18100 1.47900   1.000 43.20394 ? 393 ASN   A CA  1 
ATOM   1389 C C   . ASN   A 1 197 ? 8.55400   -15.10100 0.58200   1.000 40.98413 ? 393 ASN   A C   1 
ATOM   1390 O O   . ASN   A 1 197 ? 7.62800   -14.68500 -0.11800  1.000 43.93567 ? 393 ASN   A O   1 
ATOM   1391 C CB  . ASN   A 1 197 ? 8.64100   -12.88300 1.78100   1.000 43.97219 ? 393 ASN   A CB  1 
ATOM   1392 C CG  . ASN   A 1 197 ? 7.68700   -13.02300 2.95200   1.000 37.69363 ? 393 ASN   A CG  1 
ATOM   1393 O OD1 . ASN   A 1 197 ? 7.30100   -14.13300 3.32100   1.000 44.81501 ? 393 ASN   A OD1 1 
ATOM   1394 N ND2 . ASN   A 1 197 ? 7.29500   -11.89700 3.53700   1.000 52.86995 ? 393 ASN   A ND2 1 
ATOM   1395 N N   . VAL   A 1 198 ? 8.90000   -16.38900 0.62400   1.000 42.47620 ? 394 VAL   A N   1 
ATOM   1396 C CA  . VAL   A 1 198 ? 8.20300   -17.38000 -0.19100  1.000 43.44116 ? 394 VAL   A CA  1 
ATOM   1397 C C   . VAL   A 1 198 ? 6.75700   -17.53100 0.26700   1.000 47.09801 ? 394 VAL   A C   1 
ATOM   1398 O O   . VAL   A 1 198 ? 5.83100   -17.55900 -0.55200  1.000 37.78570 ? 394 VAL   A O   1 
ATOM   1399 C CB  . VAL   A 1 198 ? 8.94700   -18.72600 -0.14900  1.000 47.92076 ? 394 VAL   A CB  1 
ATOM   1400 C CG1 . VAL   A 1 198 ? 8.24500   -19.75300 -1.02800  1.000 42.48871 ? 394 VAL   A CG1 1 
ATOM   1401 C CG2 . VAL   A 1 198 ? 10.39600  -18.54600 -0.58400  1.000 45.56497 ? 394 VAL   A CG2 1 
ATOM   1402 N N   . GLY   A 1 199 ? 6.54300   -17.62900 1.58100   1.000 43.24959 ? 395 GLY   A N   1 
ATOM   1403 C CA  . GLY   A 1 199 ? 5.20600   -17.90400 2.08800   1.000 40.43628 ? 395 GLY   A CA  1 
ATOM   1404 C C   . GLY   A 1 199 ? 4.21000   -16.80600 1.76700   1.000 45.94229 ? 395 GLY   A C   1 
ATOM   1405 O O   . GLY   A 1 199 ? 3.03800   -17.07900 1.49500   1.000 44.63360 ? 395 GLY   A O   1 
ATOM   1406 N N   . HIS   A 1 200 ? 4.65900   -15.55000 1.80200   1.000 37.48982 ? 396 HIS   A N   1 
ATOM   1407 C CA  . HIS   A 1 200 ? 3.77300   -14.43500 1.49000   1.000 43.41442 ? 396 HIS   A CA  1 
ATOM   1408 C C   . HIS   A 1 200 ? 3.50900   -14.33500 -0.00600  1.000 40.10931 ? 396 HIS   A C   1 
ATOM   1409 O O   . HIS   A 1 200 ? 2.36400   -14.12800 -0.42400  1.000 39.02925 ? 396 HIS   A O   1 
ATOM   1410 C CB  . HIS   A 1 200 ? 4.37300   -13.13000 2.00900   1.000 42.66331 ? 396 HIS   A CB  1 
ATOM   1411 C CG  . HIS   A 1 200 ? 3.54300   -11.92100 1.71300   1.000 47.37225 ? 396 HIS   A CG  1 
ATOM   1412 N ND1 . HIS   A 1 200 ? 4.01700   -10.85600 0.97700   1.000 51.92314 ? 396 HIS   A ND1 1 
ATOM   1413 C CD2 . HIS   A 1 200 ? 2.27400   -11.60100 2.06300   1.000 48.91093 ? 396 HIS   A CD2 1 
ATOM   1414 C CE1 . HIS   A 1 200 ? 3.07400   -9.93600  0.87800   1.000 48.38331 ? 396 HIS   A CE1 1 
ATOM   1415 N NE2 . HIS   A 1 200 ? 2.00600   -10.36300 1.52900   1.000 48.83686 ? 396 HIS   A NE2 1 
ATOM   1416 N N   . ILE   A 1 201 ? 4.55600   -14.47600 -0.82200  1.000 40.41075 ? 397 ILE   A N   1 
ATOM   1417 C CA  . ILE   A 1 201 ? 4.37700   -14.44900 -2.27000  1.000 34.56779 ? 397 ILE   A CA  1 
ATOM   1418 C C   . ILE   A 1 201 ? 3.47300   -15.59400 -2.70900  1.000 35.68363 ? 397 ILE   A C   1 
ATOM   1419 O O   . ILE   A 1 201 ? 2.61900   -15.42800 -3.58800  1.000 34.80357 ? 397 ILE   A O   1 
ATOM   1420 C CB  . ILE   A 1 201 ? 5.74600   -14.48800 -2.97900  1.000 35.09436 ? 397 ILE   A CB  1 
ATOM   1421 C CG1 . ILE   A 1 201 ? 6.52600   -13.19900 -2.70200  1.000 34.05283 ? 397 ILE   A CG1 1 
ATOM   1422 C CG2 . ILE   A 1 201 ? 5.57900   -14.68200 -4.47600  1.000 30.49927 ? 397 ILE   A CG2 1 
ATOM   1423 C CD1 . ILE   A 1 201 ? 7.94800   -13.21500 -3.23800  1.000 36.47738 ? 397 ILE   A CD1 1 
ATOM   1424 N N   . GLU   A 1 202 ? 3.62900   -16.76600 -2.08600  1.000 32.37734 ? 398 GLU   A N   1 
ATOM   1425 C CA  . GLU   A 1 202 ? 2.72200   -17.87700 -2.35700  1.000 36.58990 ? 398 GLU   A CA  1 
ATOM   1426 C C   . GLU   A 1 202 ? 1.28000   -17.50400 -2.03500  1.000 38.29142 ? 398 GLU   A C   1 
ATOM   1427 O O   . GLU   A 1 202 ? 0.35700   -17.87500 -2.76900  1.000 38.69659 ? 398 GLU   A O   1 
ATOM   1428 C CB  . GLU   A 1 202 ? 3.14300   -19.10900 -1.55600  1.000 41.58303 ? 398 GLU   A CB  1 
ATOM   1429 C CG  . GLU   A 1 202 ? 4.28200   -19.90400 -2.17200  1.000 43.06168 ? 398 GLU   A CG  1 
ATOM   1430 C CD  . GLU   A 1 202 ? 4.63300   -21.13700 -1.35800  1.000 53.94387 ? 398 GLU   A CD  1 
ATOM   1431 O OE1 . GLU   A 1 202 ? 4.25100   -21.19400 -0.16900  1.000 52.41517 ? 398 GLU   A OE1 1 
ATOM   1432 O OE2 . GLU   A 1 202 ? 5.29000   -22.04700 -1.90700  1.000 53.77633 ? 398 GLU   A OE2 1 
ATOM   1433 N N   . LYS   A 1 203 ? 1.06500   -16.77300 -0.93800  1.000 39.13461 ? 399 LYS   A N   1 
ATOM   1434 C CA  . LYS   A 1 203 ? -0.28900  -16.34300 -0.60100  1.000 39.48378 ? 399 LYS   A CA  1 
ATOM   1435 C C   . LYS   A 1 203 ? -0.80500  -15.32400 -1.60800  1.000 38.14831 ? 399 LYS   A C   1 
ATOM   1436 O O   . LYS   A 1 203 ? -1.98900  -15.34200 -1.96800  1.000 30.48084 ? 399 LYS   A O   1 
ATOM   1437 C CB  . LYS   A 1 203 ? -0.32400  -15.77500 0.81700   1.000 43.29693 ? 399 LYS   A CB  1 
ATOM   1438 C CG  . LYS   A 1 203 ? -0.20200  -16.83700 1.89900   1.000 43.34291 ? 399 LYS   A CG  1 
ATOM   1439 C CD  . LYS   A 1 203 ? -1.40300  -17.77200 1.88500   1.000 52.91254 ? 399 LYS   A CD  1 
ATOM   1440 C CE  . LYS   A 1 203 ? -1.41100  -18.68800 3.10000   1.000 58.06267 ? 399 LYS   A CE  1 
ATOM   1441 N NZ  . LYS   A 1 203 ? -2.38500  -19.80700 2.95000   1.000 60.17740 ? 399 LYS   A NZ  1 
ATOM   1442 N N   . MET   A 1 204 ? 0.06900   -14.43300 -2.07700  1.000 31.28677 ? 400 MET   A N   1 
ATOM   1443 C CA  . MET   A 1 204 ? -0.31400  -13.50700 -3.13400  1.000 30.88337 ? 400 MET   A CA  1 
ATOM   1444 C C   . MET   A 1 204 ? -0.75800  -14.26100 -4.37700  1.000 33.10335 ? 400 MET   A C   1 
ATOM   1445 O O   . MET   A 1 204 ? -1.79800  -13.94900 -4.96800  1.000 32.77044 ? 400 MET   A O   1 
ATOM   1446 C CB  . MET   A 1 204 ? 0.85000   -12.57500 -3.46800  1.000 35.48825 ? 400 MET   A CB  1 
ATOM   1447 C CG  . MET   A 1 204 ? 0.95100   -11.36400 -2.57800  1.000 42.21240 ? 400 MET   A CG  1 
ATOM   1448 S SD  . MET   A 1 204 ? 2.47300   -10.46400 -2.90400  1.000 44.67109 ? 400 MET   A SD  1 
ATOM   1449 C CE  . MET   A 1 204 ? 2.26700   -10.05000 -4.63100  1.000 33.98185 ? 400 MET   A CE  1 
ATOM   1450 N N   . GLN   A 1 205 ? 0.02100   -15.26700 -4.78500  1.000 30.82703 ? 401 GLN   A N   1 
ATOM   1451 C CA  . GLN   A 1 205 ? -0.35600  -16.05300 -5.95400  1.000 33.66999 ? 401 GLN   A CA  1 
ATOM   1452 C C   . GLN   A 1 205 ? -1.65700  -16.80000 -5.72000  1.000 32.46344 ? 401 GLN   A C   1 
ATOM   1453 O O   . GLN   A 1 205 ? -2.48600  -16.90700 -6.63000  1.000 29.12768 ? 401 GLN   A O   1 
ATOM   1454 C CB  . GLN   A 1 205 ? 0.74000   -17.04400 -6.32600  1.000 36.59932 ? 401 GLN   A CB  1 
ATOM   1455 C CG  . GLN   A 1 205 ? 0.58900   -17.55800 -7.75200  1.000 40.82059 ? 401 GLN   A CG  1 
ATOM   1456 C CD  . GLN   A 1 205 ? 1.56700   -18.65900 -8.09200  1.000 40.34100 ? 401 GLN   A CD  1 
ATOM   1457 O OE1 . GLN   A 1 205 ? 1.84500   -19.53300 -7.27200  1.000 45.67386 ? 401 GLN   A OE1 1 
ATOM   1458 N NE2 . GLN   A 1 205 ? 2.09400   -18.62500 -9.31200  1.000 35.94439 ? 401 GLN   A NE2 1 
ATOM   1459 N N   . GLU   A 1 206 ? -1.83800  -17.34600 -4.51500  1.000 32.02791 ? 402 GLU   A N   1 
ATOM   1460 C CA  . GLU   A 1 206 ? -3.07300  -18.05700 -4.20400  1.000 34.79604 ? 402 GLU   A CA  1 
ATOM   1461 C C   . GLU   A 1 206 ? -4.28400  -17.16400 -4.42500  1.000 25.55140 ? 402 GLU   A C   1 
ATOM   1462 O O   . GLU   A 1 206 ? -5.28400  -17.59500 -5.01000  1.000 31.01262 ? 402 GLU   A O   1 
ATOM   1463 C CB  . GLU   A 1 206 ? -3.03200  -18.57400 -2.76500  1.000 36.75431 ? 402 GLU   A CB  1 
ATOM   1464 C CG  . GLU   A 1 206 ? -3.61400  -19.96800 -2.59200  1.000 39.71113 ? 402 GLU   A CG  1 
ATOM   1465 C CD  . GLU   A 1 206 ? -3.92900  -20.29500 -1.14100  1.000 53.52704 ? 402 GLU   A CD  1 
ATOM   1466 O OE1 . GLU   A 1 206 ? -4.59100  -21.32600 -0.89100  1.000 49.06803 ? 402 GLU   A OE1 1 
ATOM   1467 O OE2 . GLU   A 1 206 ? -3.50700  -19.52600 -0.24900  1.000 49.95099 ? 402 GLU   A OE2 1 
ATOM   1468 N N   . GLY   A 1 207 ? -4.19800  -15.90400 -3.99400  1.000 28.35822 ? 403 GLY   A N   1 
ATOM   1469 C CA  . GLY   A 1 207 ? -5.29900  -14.98200 -4.21100  1.000 30.30222 ? 403 GLY   A CA  1 
ATOM   1470 C C   . GLY   A 1 207 ? -5.50600  -14.64700 -5.67500  1.000 30.63458 ? 403 GLY   A C   1 
ATOM   1471 O O   . GLY   A 1 207 ? -6.64000  -14.62100 -6.16000  1.000 27.42308 ? 403 GLY   A O   1 
ATOM   1472 N N   . ILE   A 1 208 ? -4.41700  -14.37800 -6.40000  1.000 23.98782 ? 404 ILE   A N   1 
ATOM   1473 C CA  . ILE   A 1 208 ? -4.53000  -14.11900 -7.83500  1.000 24.61506 ? 404 ILE   A CA  1 
ATOM   1474 C C   . ILE   A 1 208 ? -5.10200  -15.33900 -8.54600  1.000 25.03515 ? 404 ILE   A C   1 
ATOM   1475 O O   . ILE   A 1 208 ? -6.01400  -15.22800 -9.37400  1.000 25.82224 ? 404 ILE   A O   1 
ATOM   1476 C CB  . ILE   A 1 208 ? -3.16500  -13.71200 -8.42000  1.000 26.06834 ? 404 ILE   A CB  1 
ATOM   1477 C CG1 . ILE   A 1 208 ? -2.74800  -12.33600 -7.89800  1.000 30.14828 ? 404 ILE   A CG1 1 
ATOM   1478 C CG2 . ILE   A 1 208 ? -3.20900  -13.71900 -9.95000  1.000 22.58046 ? 404 ILE   A CG2 1 
ATOM   1479 C CD1 . ILE   A 1 208 ? -1.26800  -12.06400 -8.01500  1.000 31.80786 ? 404 ILE   A CD1 1 
ATOM   1480 N N   . VAL   A 1 209 ? -4.57800  -16.52400 -8.22500  1.000 27.66295 ? 405 VAL   A N   1 
ATOM   1481 C CA  . VAL   A 1 209 ? -5.04600  -17.74700 -8.87200  1.000 31.97688 ? 405 VAL   A CA  1 
ATOM   1482 C C   . VAL   A 1 209 ? -6.50900  -18.01000 -8.53700  1.000 31.22098 ? 405 VAL   A C   1 
ATOM   1483 O O   . VAL   A 1 209 ? -7.29900  -18.40100 -9.40400  1.000 27.87086 ? 405 VAL   A O   1 
ATOM   1484 C CB  . VAL   A 1 209 ? -4.14400  -18.93300 -8.48000  1.000 34.29756 ? 405 VAL   A CB  1 
ATOM   1485 C CG1 . VAL   A 1 209 ? -4.82800  -20.24900 -8.77900  1.000 40.71052 ? 405 VAL   A CG1 1 
ATOM   1486 C CG2 . VAL   A 1 209 ? -2.81600  -18.84000 -9.21900  1.000 31.88288 ? 405 VAL   A CG2 1 
ATOM   1487 N N   . HIS   A 1 210 ? -6.89800  -17.79100 -7.28000  1.000 26.66050 ? 406 HIS   A N   1 
ATOM   1488 C CA  . HIS   A 1 210 ? -8.29600  -17.97000 -6.90500  1.000 28.73657 ? 406 HIS   A CA  1 
ATOM   1489 C C   . HIS   A 1 210 ? -9.20000  -17.01600 -7.67700  1.000 27.51234 ? 406 HIS   A C   1 
ATOM   1490 O O   . HIS   A 1 210 ? -10.27200 -17.41100 -8.15200  1.000 30.24869 ? 406 HIS   A O   1 
ATOM   1491 C CB  . HIS   A 1 210 ? -8.46700  -17.76900 -5.40000  1.000 33.39739 ? 406 HIS   A CB  1 
ATOM   1492 C CG  . HIS   A 1 210 ? -9.88800  -17.56400 -4.98000  1.000 38.09545 ? 406 HIS   A CG  1 
ATOM   1493 N ND1 . HIS   A 1 210 ? -10.78400 -18.60400 -4.85600  1.000 47.07939 ? 406 HIS   A ND1 1 
ATOM   1494 C CD2 . HIS   A 1 210 ? -10.57100 -16.43900 -4.66200  1.000 39.76233 ? 406 HIS   A CD2 1 
ATOM   1495 C CE1 . HIS   A 1 210 ? -11.95700 -18.12900 -4.47900  1.000 43.52184 ? 406 HIS   A CE1 1 
ATOM   1496 N NE2 . HIS   A 1 210 ? -11.85400 -16.81800 -4.35400  1.000 46.10399 ? 406 HIS   A NE2 1 
ATOM   1497 N N   . VAL   A 1 211 ? -8.77900  -15.75800 -7.82200  1.000 24.14731 ? 407 VAL   A N   1 
ATOM   1498 C CA  . VAL   A 1 211 ? -9.56200  -14.79500 -8.59100  1.000 26.38876 ? 407 VAL   A CA  1 
ATOM   1499 C C   . VAL   A 1 211 ? -9.60800  -15.20000 -10.06000 1.000 30.32852 ? 407 VAL   A C   1 
ATOM   1500 O O   . VAL   A 1 211 ? -10.62800 -15.02300 -10.74000 1.000 28.43836 ? 407 VAL   A O   1 
ATOM   1501 C CB  . VAL   A 1 211 ? -8.98900  -13.37900 -8.39500  1.000 33.56937 ? 407 VAL   A CB  1 
ATOM   1502 C CG1 . VAL   A 1 211 ? -9.36400  -12.47700 -9.54800  1.000 37.89460 ? 407 VAL   A CG1 1 
ATOM   1503 C CG2 . VAL   A 1 211 ? -9.48700  -12.79100 -7.08000  1.000 39.05632 ? 407 VAL   A CG2 1 
ATOM   1504 N N   . LEU   A 1 212 ? -8.51400  -15.77000 -10.56700 1.000 27.43569 ? 408 LEU   A N   1 
ATOM   1505 C CA  . LEU   A 1 212 ? -8.49700  -16.27300 -11.93900 1.000 22.95447 ? 408 LEU   A CA  1 
ATOM   1506 C C   . LEU   A 1 212 ? -9.48200  -17.42500 -12.11600 1.000 27.88268 ? 408 LEU   A C   1 
ATOM   1507 O O   . LEU   A 1 212 ? -10.23700 -17.46200 -13.09400 1.000 28.59438 ? 408 LEU   A O   1 
ATOM   1508 C CB  . LEU   A 1 212 ? -7.07600  -16.70300 -12.31500 1.000 22.84531 ? 408 LEU   A CB  1 
ATOM   1509 C CG  . LEU   A 1 212 ? -6.88500  -17.41800 -13.65900 1.000 24.98906 ? 408 LEU   A CG  1 
ATOM   1510 C CD1 . LEU   A 1 212 ? -7.22100  -16.49900 -14.81800 1.000 25.47333 ? 408 LEU   A CD1 1 
ATOM   1511 C CD2 . LEU   A 1 212 ? -5.46800  -17.95500 -13.78800 1.000 24.50194 ? 408 LEU   A CD2 1 
ATOM   1512 N N   . ARG   A 1 213 ? -9.48300  -18.38200 -11.17900 1.000 24.78265 ? 409 ARG   A N   1 
ATOM   1513 C CA  . ARG   A 1 213 ? -10.44500 -19.48200 -11.22600 1.000 30.04866 ? 409 ARG   A CA  1 
ATOM   1514 C C   . ARG   A 1 213 ? -11.87200 -18.96400 -11.29700 1.000 27.99092 ? 409 ARG   A C   1 
ATOM   1515 O O   . ARG   A 1 213 ? -12.66800 -19.40500 -12.13400 1.000 32.70818 ? 409 ARG   A O   1 
ATOM   1516 C CB  . ARG   A 1 213 ? -10.29300 -20.38600 -10.00100 1.000 32.91966 ? 409 ARG   A CB  1 
ATOM   1517 C CG  . ARG   A 1 213 ? -8.93500  -20.99800 -9.79500  1.000 38.20892 ? 409 ARG   A CG  1 
ATOM   1518 C CD  . ARG   A 1 213 ? -9.06300  -22.46300 -9.41100  1.000 45.60978 ? 409 ARG   A CD  1 
ATOM   1519 N NE  . ARG   A 1 213 ? -9.94500  -22.67300 -8.27000  1.000 49.10034 ? 409 ARG   A NE  1 
ATOM   1520 C CZ  . ARG   A 1 213 ? -9.58800  -22.49100 -7.00400  1.000 57.12996 ? 409 ARG   A CZ  1 
ATOM   1521 N NH1 . ARG   A 1 213 ? -8.37900  -22.05800 -6.68100  1.000 50.54857 ? 409 ARG   A NH1 1 
ATOM   1522 N NH2 . ARG   A 1 213 ? -10.46600 -22.75200 -6.03900  1.000 61.47830 ? 409 ARG   A NH2 1 
ATOM   1523 N N   . LEU   A 1 214 ? -12.21400 -18.03300 -10.40500 1.000 30.61199 ? 410 LEU   A N   1 
ATOM   1524 C CA  . LEU   A 1 214 ? -13.56500 -17.48600 -10.38000 1.000 32.97838 ? 410 LEU   A CA  1 
ATOM   1525 C C   . LEU   A 1 214 ? -13.88300 -16.76200 -11.68000 1.000 32.28489 ? 410 LEU   A C   1 
ATOM   1526 O O   . LEU   A 1 214 ? -14.99500 -16.87300 -12.21000 1.000 32.67338 ? 410 LEU   A O   1 
ATOM   1527 C CB  . LEU   A 1 214 ? -13.72100 -16.54300 -9.18600  1.000 31.58009 ? 410 LEU   A CB  1 
ATOM   1528 C CG  . LEU   A 1 214 ? -14.24700 -17.13800 -7.87700  1.000 41.58315 ? 410 LEU   A CG  1 
ATOM   1529 C CD1 . LEU   A 1 214 ? -13.64300 -18.50700 -7.59500  1.000 45.47964 ? 410 LEU   A CD1 1 
ATOM   1530 C CD2 . LEU   A 1 214 ? -13.99300 -16.18700 -6.71800  1.000 46.83904 ? 410 LEU   A CD2 1 
ATOM   1531 N N   . HIS   A 1 215 ? -12.90700 -16.02900 -12.22000 1.000 28.89444 ? 411 HIS   A N   1 
ATOM   1532 C CA  . HIS   A 1 215 ? -13.12400 -15.29900 -13.46100 1.000 27.38085 ? 411 HIS   A CA  1 
ATOM   1533 C C   . HIS   A 1 215 ? -13.32400 -16.24600 -14.63600 1.000 25.88007 ? 411 HIS   A C   1 
ATOM   1534 O O   . HIS   A 1 215 ? -14.16700 -15.99700 -15.50500 1.000 29.10816 ? 411 HIS   A O   1 
ATOM   1535 C CB  . HIS   A 1 215 ? -11.94800 -14.35900 -13.72100 1.000 25.76375 ? 411 HIS   A CB  1 
ATOM   1536 C CG  . HIS   A 1 215 ? -12.11100 -13.51300 -14.94300 1.000 31.61062 ? 411 HIS   A CG  1 
ATOM   1537 N ND1 . HIS   A 1 215 ? -12.82000 -12.33200 -14.94000 1.000 35.45971 ? 411 HIS   A ND1 1 
ATOM   1538 C CD2 . HIS   A 1 215 ? -11.65600 -13.67600 -16.20800 1.000 29.37066 ? 411 HIS   A CD2 1 
ATOM   1539 C CE1 . HIS   A 1 215 ? -12.79500 -11.80200 -16.15000 1.000 34.81757 ? 411 HIS   A CE1 1 
ATOM   1540 N NE2 . HIS   A 1 215 ? -12.09200 -12.59600 -16.93700 1.000 33.17325 ? 411 HIS   A NE2 1 
ATOM   1541 N N   . LEU   A 1 216 ? -12.54700 -17.33100 -14.69300 1.000 25.24850 ? 412 LEU   A N   1 
ATOM   1542 C CA  . LEU   A 1 216 ? -12.71900 -18.29000 -15.77700 1.000 27.64741 ? 412 LEU   A CA  1 
ATOM   1543 C C   . LEU   A 1 216 ? -14.07200 -18.97900 -15.69000 1.000 31.28527 ? 412 LEU   A C   1 
ATOM   1544 O O   . LEU   A 1 216 ? -14.66700 -19.30400 -16.72200 1.000 33.18235 ? 412 LEU   A O   1 
ATOM   1545 C CB  . LEU   A 1 216 ? -11.59600 -19.32500 -15.75600 1.000 28.20318 ? 412 LEU   A CB  1 
ATOM   1546 C CG  . LEU   A 1 216 ? -10.17700 -18.82000 -16.03000 1.000 27.69454 ? 412 LEU   A CG  1 
ATOM   1547 C CD1 . LEU   A 1 216 ? -9.19900  -19.98000 -15.95400 1.000 26.63385 ? 412 LEU   A CD1 1 
ATOM   1548 C CD2 . LEU   A 1 216 ? -10.08400 -18.12800 -17.37900 1.000 28.10399 ? 412 LEU   A CD2 1 
ATOM   1549 N N   . GLN   A 1 217 ? -14.56800 -19.19900 -14.46900 1.000 31.93618 ? 413 GLN   A N   1 
ATOM   1550 C CA  . GLN   A 1 217 ? -15.89100 -19.78600 -14.28300 1.000 38.65714 ? 413 GLN   A CA  1 
ATOM   1551 C C   . GLN   A 1 217 ? -16.97600 -18.90500 -14.89000 1.000 36.33694 ? 413 GLN   A C   1 
ATOM   1552 O O   . GLN   A 1 217 ? -17.89000 -19.40200 -15.56100 1.000 42.39862 ? 413 GLN   A O   1 
ATOM   1553 C CB  . GLN   A 1 217 ? -16.15700 -19.99300 -12.79200 1.000 39.21677 ? 413 GLN   A CB  1 
ATOM   1554 C CG  . GLN   A 1 217 ? -15.50400 -21.22200 -12.19400 1.000 48.79684 ? 413 GLN   A CG  1 
ATOM   1555 C CD  . GLN   A 1 217 ? -15.91500 -21.45800 -10.75100 1.000 56.54163 ? 413 GLN   A CD  1 
ATOM   1556 O OE1 . GLN   A 1 217 ? -16.92000 -20.92000 -10.28400 1.000 53.32906 ? 413 GLN   A OE1 1 
ATOM   1557 N NE2 . GLN   A 1 217 ? -15.13200 -22.25700 -10.03600 1.000 57.97409 ? 413 GLN   A NE2 1 
ATOM   1558 N N   . SER   A 1 218 ? -16.89500 -17.59200 -14.66000 1.000 37.28660 ? 414 SER   A N   1 
ATOM   1559 C CA  . SER   A 1 218 ? -17.90500 -16.66900 -15.16400 1.000 34.83905 ? 414 SER   A CA  1 
ATOM   1560 C C   . SER   A 1 218 ? -17.70400 -16.36400 -16.64200 1.000 41.77957 ? 414 SER   A C   1 
ATOM   1561 O O   . SER   A 1 218 ? -18.67500 -16.29200 -17.40300 1.000 38.62874 ? 414 SER   A O   1 
ATOM   1562 C CB  . SER   A 1 218 ? -17.88000 -15.37000 -14.35900 1.000 39.32872 ? 414 SER   A CB  1 
ATOM   1563 O OG  . SER   A 1 218 ? -18.07400 -15.61400 -12.97700 1.000 44.52658 ? 414 SER   A OG  1 
ATOM   1564 N N   . ASN   A 1 219 ? -16.45000 -16.18400 -17.06400 1.000 35.17192 ? 415 ASN   A N   1 
ATOM   1565 C CA  . ASN   A 1 219 ? -16.16800 -15.72500 -18.41800 1.000 30.03731 ? 415 ASN   A CA  1 
ATOM   1566 C C   . ASN   A 1 219 ? -16.18100 -16.85600 -19.43700 1.000 31.34713 ? 415 ASN   A C   1 
ATOM   1567 O O   . ASN   A 1 219 ? -16.40800 -16.60400 -20.62500 1.000 29.79447 ? 415 ASN   A O   1 
ATOM   1568 C CB  . ASN   A 1 219 ? -14.81600 -15.01200 -18.44900 1.000 31.50944 ? 415 ASN   A CB  1 
ATOM   1569 C CG  . ASN   A 1 219 ? -14.69000 -14.05300 -19.60800 1.000 38.49495 ? 415 ASN   A CG  1 
ATOM   1570 O OD1 . ASN   A 1 219 ? -15.68300 -13.49800 -20.08300 1.000 36.74779 ? 415 ASN   A OD1 1 
ATOM   1571 N ND2 . ASN   A 1 219 ? -13.45900 -13.84200 -20.06900 1.000 28.28603 ? 415 ASN   A ND2 1 
ATOM   1572 N N   . HIS   A 1 220 ? -15.92900 -18.09100 -19.00600 1.000 28.57560 ? 416 HIS   A N   1 
ATOM   1573 C CA  . HIS   A 1 220 ? -15.84700 -19.24300 -19.90400 1.000 28.71321 ? 416 HIS   A CA  1 
ATOM   1574 C C   . HIS   A 1 220 ? -16.66000 -20.40200 -19.34600 1.000 35.12618 ? 416 HIS   A C   1 
ATOM   1575 O O   . HIS   A 1 220 ? -16.12600 -21.48600 -19.09200 1.000 32.49394 ? 416 HIS   A O   1 
ATOM   1576 C CB  . HIS   A 1 220 ? -14.39200 -19.66100 -20.12100 1.000 26.19273 ? 416 HIS   A CB  1 
ATOM   1577 C CG  . HIS   A 1 220 ? -13.55000 -18.60300 -20.75700 1.000 29.93956 ? 416 HIS   A CG  1 
ATOM   1578 N ND1 . HIS   A 1 220 ? -13.42000 -18.48100 -22.12400 1.000 36.24015 ? 416 HIS   A ND1 1 
ATOM   1579 C CD2 . HIS   A 1 220 ? -12.79600 -17.61600 -20.21900 1.000 28.76252 ? 416 HIS   A CD2 1 
ATOM   1580 C CE1 . HIS   A 1 220 ? -12.62600 -17.46200 -22.39900 1.000 33.60090 ? 416 HIS   A CE1 1 
ATOM   1581 N NE2 . HIS   A 1 220 ? -12.23500 -16.91800 -21.26100 1.000 25.77449 ? 416 HIS   A NE2 1 
ATOM   1582 N N   . PRO   A 1 221 ? -17.97400 -20.21700 -19.16700 1.000 36.27431 ? 417 PRO   A N   1 
ATOM   1583 C CA  . PRO   A 1 221 ? -18.79200 -21.30100 -18.60500 1.000 33.56805 ? 417 PRO   A CA  1 
ATOM   1584 C C   . PRO   A 1 221 ? -18.90700 -22.50300 -19.52100 1.000 39.25559 ? 417 PRO   A C   1 
ATOM   1585 O O   . PRO   A 1 221 ? -19.34800 -23.56600 -19.06700 1.000 49.16347 ? 417 PRO   A O   1 
ATOM   1586 C CB  . PRO   A 1 221 ? -20.15800 -20.63600 -18.38100 1.000 33.90437 ? 417 PRO   A CB  1 
ATOM   1587 C CG  . PRO   A 1 221 ? -20.21200 -19.50900 -19.34400 1.000 39.57403 ? 417 PRO   A CG  1 
ATOM   1588 C CD  . PRO   A 1 221 ? -18.79400 -19.11400 -19.69900 1.000 40.55887 ? 417 PRO   A CD  1 
ATOM   1589 N N   . ASP   A 1 222 ? -18.51200 -22.37600 -20.78500 1.000 39.47663 ? 418 ASP   A N   1 
ATOM   1590 C CA  . ASP   A 1 222 ? -18.57300 -23.48200 -21.72600 1.000 41.26166 ? 418 ASP   A CA  1 
ATOM   1591 C C   . ASP   A 1 222 ? -17.40500 -24.44800 -21.58800 1.000 37.98838 ? 418 ASP   A C   1 
ATOM   1592 O O   . ASP   A 1 222 ? -17.44000 -25.52200 -22.19400 1.000 45.03615 ? 418 ASP   A O   1 
ATOM   1593 C CB  . ASP   A 1 222 ? -18.63600 -22.93500 -23.15400 1.000 37.49635 ? 418 ASP   A CB  1 
ATOM   1594 C CG  . ASP   A 1 222 ? -17.60400 -21.84600 -23.41300 1.000 52.17543 ? 418 ASP   A CG  1 
ATOM   1595 O OD1 . ASP   A 1 222 ? -17.17800 -21.17200 -22.45000 1.000 42.49880 ? 418 ASP   A OD1 1 
ATOM   1596 O OD2 . ASP   A 1 222 ? -17.22800 -21.65300 -24.58600 1.000 51.60992 ? 418 ASP   A OD2 1 
ATOM   1597 N N   . ASP   A 1 223 ? -16.38000 -24.10300 -20.81000 1.000 42.31336 ? 419 ASP   A N   1 
ATOM   1598 C CA  . ASP   A 1 223 ? -15.20000 -24.94800 -20.62000 1.000 39.89535 ? 419 ASP   A CA  1 
ATOM   1599 C C   . ASP   A 1 223 ? -14.90800 -24.97500 -19.12300 1.000 45.74030 ? 419 ASP   A C   1 
ATOM   1600 O O   . ASP   A 1 223 ? -14.15800 -24.14000 -18.61000 1.000 37.68468 ? 419 ASP   A O   1 
ATOM   1601 C CB  . ASP   A 1 223 ? -14.01000 -24.42500 -21.42400 1.000 45.55624 ? 419 ASP   A CB  1 
ATOM   1602 C CG  . ASP   A 1 223 ? -12.80700 -25.35400 -21.37200 1.000 44.43321 ? 419 ASP   A CG  1 
ATOM   1603 O OD1 . ASP   A 1 223 ? -12.84400 -26.35500 -20.62700 1.000 50.32501 ? 419 ASP   A OD1 1 
ATOM   1604 O OD2 . ASP   A 1 223 ? -11.81600 -25.07900 -22.08200 1.000 45.72296 ? 419 ASP   A OD2 1 
ATOM   1605 N N   . ILE   A 1 224 ? -15.48800 -25.94700 -18.42300 1.000 46.34166 ? 420 ILE   A N   1 
ATOM   1606 C CA  . ILE   A 1 224 ? -15.34300 -26.01500 -16.97400 1.000 47.36889 ? 420 ILE   A CA  1 
ATOM   1607 C C   . ILE   A 1 224 ? -13.98200 -26.59300 -16.60000 1.000 40.83647 ? 420 ILE   A C   1 
ATOM   1608 O O   . ILE   A 1 224 ? -13.66100 -26.71600 -15.41300 1.000 48.36032 ? 420 ILE   A O   1 
ATOM   1609 C CB  . ILE   A 1 224 ? -16.48700 -26.82900 -16.34200 1.000 48.88221 ? 420 ILE   A CB  1 
ATOM   1610 C CG1 . ILE   A 1 224 ? -16.57800 -28.22000 -16.97400 1.000 40.60373 ? 420 ILE   A CG1 1 
ATOM   1611 C CG2 . ILE   A 1 224 ? -17.81000 -26.08700 -16.49000 1.000 44.49813 ? 420 ILE   A CG2 1 
ATOM   1612 C CD1 . ILE   A 1 224 ? -16.90600 -29.31200 -15.96700 1.000 52.45563 ? 420 ILE   A CD1 1 
ATOM   1613 N N   . PHE   A 1 225 ? -13.17100 -26.93900 -17.60300 1.000 36.50806 ? 421 PHE   A N   1 
ATOM   1614 C CA  . PHE   A 1 225 ? -11.81200 -27.42500 -17.38500 1.000 37.56867 ? 421 PHE   A CA  1 
ATOM   1615 C C   . PHE   A 1 225 ? -10.74900 -26.46500 -17.91500 1.000 39.43046 ? 421 PHE   A C   1 
ATOM   1616 O O   . PHE   A 1 225 ? -9.60000  -26.87100 -18.11900 1.000 33.12163 ? 421 PHE   A O   1 
ATOM   1617 C CB  . PHE   A 1 225 ? -11.62600 -28.80500 -18.01800 1.000 44.88189 ? 421 PHE   A CB  1 
ATOM   1618 C CG  . PHE   A 1 225 ? -12.61900 -29.83000 -17.54700 1.000 45.08573 ? 421 PHE   A CG  1 
ATOM   1619 C CD1 . PHE   A 1 225 ? -13.70600 -30.18000 -18.33200 1.000 46.35782 ? 421 PHE   A CD1 1 
ATOM   1620 C CD2 . PHE   A 1 225 ? -12.47500 -30.42700 -16.30400 1.000 45.78923 ? 421 PHE   A CD2 1 
ATOM   1621 C CE1 . PHE   A 1 225 ? -14.62100 -31.12700 -17.89500 1.000 51.29872 ? 421 PHE   A CE1 1 
ATOM   1622 C CE2 . PHE   A 1 225 ? -13.38700 -31.36900 -15.85900 1.000 50.09054 ? 421 PHE   A CE2 1 
ATOM   1623 C CZ  . PHE   A 1 225 ? -14.46100 -31.72000 -16.65300 1.000 48.91675 ? 421 PHE   A CZ  1 
ATOM   1624 N N   . LEU   A 1 226 ? -11.10000 -25.19600 -18.13100 1.000 31.74329 ? 422 LEU   A N   1 
ATOM   1625 C CA  . LEU   A 1 226 ? -10.12800 -24.25200 -18.67300 1.000 34.39375 ? 422 LEU   A CA  1 
ATOM   1626 C C   . LEU   A 1 226 ? -8.99200  -23.97900 -17.69200 1.000 23.36556 ? 422 LEU   A C   1 
ATOM   1627 O O   . LEU   A 1 226 ? -7.84300  -23.80000 -18.11100 1.000 25.87216 ? 422 LEU   A O   1 
ATOM   1628 C CB  . LEU   A 1 226 ? -10.83400 -22.95100 -19.06500 1.000 25.80442 ? 422 LEU   A CB  1 
ATOM   1629 C CG  . LEU   A 1 226 ? -9.99500  -21.77900 -19.57900 1.000 25.98716 ? 422 LEU   A CG  1 
ATOM   1630 C CD1 . LEU   A 1 226 ? -9.12900  -22.18600 -20.76100 1.000 23.89010 ? 422 LEU   A CD1 1 
ATOM   1631 C CD2 . LEU   A 1 226 ? -10.91000 -20.62700 -19.96800 1.000 23.38584 ? 422 LEU   A CD2 1 
ATOM   1632 N N   . PHE   A 1 227 ? -9.27900  -23.95300 -16.38900 1.000 24.47326 ? 423 PHE   A N   1 
ATOM   1633 C CA  . PHE   A 1 227 ? -8.24000  -23.60200 -15.42200 1.000 27.54337 ? 423 PHE   A CA  1 
ATOM   1634 C C   . PHE   A 1 227 ? -7.07900  -24.59300 -15.39600 1.000 26.98223 ? 423 PHE   A C   1 
ATOM   1635 O O   . PHE   A 1 227 ? -5.91900  -24.14500 -15.41700 1.000 22.84029 ? 423 PHE   A O   1 
ATOM   1636 C CB  . PHE   A 1 227 ? -8.85300  -23.42800 -14.02800 1.000 22.62033 ? 423 PHE   A CB  1 
ATOM   1637 C CG  . PHE   A 1 227 ? -7.83500  -23.15500 -12.96600 1.000 30.34977 ? 423 PHE   A CG  1 
ATOM   1638 C CD1 . PHE   A 1 227 ? -7.18200  -21.93400 -12.91200 1.000 24.42647 ? 423 PHE   A CD1 1 
ATOM   1639 C CD2 . PHE   A 1 227 ? -7.50000  -24.13100 -12.04400 1.000 36.33189 ? 423 PHE   A CD2 1 
ATOM   1640 C CE1 . PHE   A 1 227 ? -6.23400  -21.68300 -11.94500 1.000 30.27682 ? 423 PHE   A CE1 1 
ATOM   1641 C CE2 . PHE   A 1 227 ? -6.54700  -23.88900 -11.07500 1.000 33.35152 ? 423 PHE   A CE2 1 
ATOM   1642 C CZ  . PHE   A 1 227 ? -5.91600  -22.66500 -11.02300 1.000 34.80669 ? 423 PHE   A CZ  1 
ATOM   1643 N N   . PRO   A 1 228 ? -7.28800  -25.91500 -15.33200 1.000 25.17086 ? 424 PRO   A N   1 
ATOM   1644 C CA  . PRO   A 1 228 ? -6.12900  -26.82100 -15.43100 1.000 23.85472 ? 424 PRO   A CA  1 
ATOM   1645 C C   . PRO   A 1 228 ? -5.37700  -26.69200 -16.74600 1.000 21.42729 ? 424 PRO   A C   1 
ATOM   1646 O O   . PRO   A 1 228 ? -4.15500  -26.88500 -16.76900 1.000 26.50306 ? 424 PRO   A O   1 
ATOM   1647 C CB  . PRO   A 1 228 ? -6.74200  -28.22200 -15.26300 1.000 26.40677 ? 424 PRO   A CB  1 
ATOM   1648 C CG  . PRO   A 1 228 ? -8.21400  -28.04900 -15.36900 1.000 29.89954 ? 424 PRO   A CG  1 
ATOM   1649 C CD  . PRO   A 1 228 ? -8.52200  -26.64100 -14.98100 1.000 26.04735 ? 424 PRO   A CD  1 
ATOM   1650 N N   . LYS   A 1 229 ? -6.06800  -26.36700 -17.84300 1.000 25.42624 ? 425 LYS   A N   1 
ATOM   1651 C CA  . LYS   A 1 229 ? -5.37600  -26.08700 -19.09700 1.000 27.89789 ? 425 LYS   A CA  1 
ATOM   1652 C C   . LYS   A 1 229 ? -4.38800  -24.94000 -18.93200 1.000 29.88366 ? 425 LYS   A C   1 
ATOM   1653 O O   . LYS   A 1 229 ? -3.26300  -25.00300 -19.43800 1.000 25.57026 ? 425 LYS   A O   1 
ATOM   1654 C CB  . LYS   A 1 229 ? -6.38200  -25.75200 -20.19900 1.000 32.60550 ? 425 LYS   A CB  1 
ATOM   1655 C CG  . LYS   A 1 229 ? -7.21700  -26.92000 -20.70200 1.000 38.25564 ? 425 LYS   A CG  1 
ATOM   1656 C CD  . LYS   A 1 229 ? -8.31900  -26.41700 -21.63100 1.000 37.05099 ? 425 LYS   A CD  1 
ATOM   1657 C CE  . LYS   A 1 229 ? -9.36700  -27.48500 -21.88100 1.000 48.83291 ? 425 LYS   A CE  1 
ATOM   1658 N NZ  . LYS   A 1 229 ? -10.50000 -26.98200 -22.70700 1.000 45.44697 ? 425 LYS   A NZ  1 
ATOM   1659 N N   . LEU   A 1 230 ? -4.79400  -23.88300 -18.21900 1.000 25.32481 ? 426 LEU   A N   1 
ATOM   1660 C CA  . LEU   A 1 230 ? -3.92400  -22.73000 -18.02200 1.000 29.19790 ? 426 LEU   A CA  1 
ATOM   1661 C C   . LEU   A 1 230 ? -2.76600  -23.03800 -17.08300 1.000 25.82147 ? 426 LEU   A C   1 
ATOM   1662 O O   . LEU   A 1 230 ? -1.66800  -22.50100 -17.26400 1.000 24.88708 ? 426 LEU   A O   1 
ATOM   1663 C CB  . LEU   A 1 230 ? -4.73700  -21.55200 -17.49300 1.000 27.77421 ? 426 LEU   A CB  1 
ATOM   1664 C CG  . LEU   A 1 230 ? -5.47100  -20.76600 -18.57300 1.000 28.58935 ? 426 LEU   A CG  1 
ATOM   1665 C CD1 . LEU   A 1 230 ? -6.23000  -19.60600 -17.96200 1.000 31.50642 ? 426 LEU   A CD1 1 
ATOM   1666 C CD2 . LEU   A 1 230 ? -4.46500  -20.27300 -19.60600 1.000 31.70850 ? 426 LEU   A CD2 1 
ATOM   1667 N N   . LEU   A 1 231 ? -2.98900  -23.88400 -16.07300 1.000 23.83685 ? 427 LEU   A N   1 
ATOM   1668 C CA  . LEU   A 1 231 ? -1.89100  -24.31900 -15.21700 1.000 25.67975 ? 427 LEU   A CA  1 
ATOM   1669 C C   . LEU   A 1 231 ? -0.79600  -24.99100 -16.03500 1.000 29.49590 ? 427 LEU   A C   1 
ATOM   1670 O O   . LEU   A 1 231 ? 0.39800   -24.74100 -15.82400 1.000 27.17393 ? 427 LEU   A O   1 
ATOM   1671 C CB  . LEU   A 1 231 ? -2.40900  -25.27300 -14.13900 1.000 31.34712 ? 427 LEU   A CB  1 
ATOM   1672 C CG  . LEU   A 1 231 ? -3.30400  -24.68400 -13.04600 1.000 32.21557 ? 427 LEU   A CG  1 
ATOM   1673 C CD1 . LEU   A 1 231 ? -3.58100  -25.71800 -11.96300 1.000 32.51813 ? 427 LEU   A CD1 1 
ATOM   1674 C CD2 . LEU   A 1 231 ? -2.67200  -23.43500 -12.45300 1.000 30.59088 ? 427 LEU   A CD2 1 
ATOM   1675 N N   . GLN   A 1 232 ? -1.18600  -25.84900 -16.97800 1.000 28.50280 ? 428 GLN   A N   1 
ATOM   1676 C CA  . GLN   A 1 232 ? -0.20300  -26.49300 -17.84000 1.000 27.69062 ? 428 GLN   A CA  1 
ATOM   1677 C C   . GLN   A 1 232 ? 0.49700   -25.47600 -18.73700 1.000 28.04862 ? 428 GLN   A C   1 
ATOM   1678 O O   . GLN   A 1 232 ? 1.69400   -25.60500 -19.01200 1.000 32.61010 ? 428 GLN   A O   1 
ATOM   1679 C CB  . GLN   A 1 232 ? -0.87800  -27.57400 -18.67600 1.000 31.79336 ? 428 GLN   A CB  1 
ATOM   1680 C CG  . GLN   A 1 232 ? 0.09900   -28.44600 -19.42600 1.000 30.54281 ? 428 GLN   A CG  1 
ATOM   1681 C CD  . GLN   A 1 232 ? -0.58400  -29.34200 -20.42600 1.000 32.83272 ? 428 GLN   A CD  1 
ATOM   1682 O OE1 . GLN   A 1 232 ? -1.52100  -28.93000 -21.11300 1.000 35.21557 ? 428 GLN   A OE1 1 
ATOM   1683 N NE2 . GLN   A 1 232 ? -0.11300  -30.57700 -20.52400 1.000 36.66873 ? 428 GLN   A NE2 1 
ATOM   1684 N N   . LYS   A 1 233 ? -0.23100  -24.45600 -19.19800 1.000 28.24293 ? 429 LYS   A N   1 
ATOM   1685 C CA  . LYS   A 1 233 ? 0.39600   -23.42700 -20.02500 1.000 23.34575 ? 429 LYS   A CA  1 
ATOM   1686 C C   . LYS   A 1 233 ? 1.50600   -22.71000 -19.26500 1.000 32.84298 ? 429 LYS   A C   1 
ATOM   1687 O O   . LYS   A 1 233 ? 2.53700   -22.34900 -19.84800 1.000 29.84351 ? 429 LYS   A O   1 
ATOM   1688 C CB  . LYS   A 1 233 ? -0.65500  -22.42900 -20.51300 1.000 27.14762 ? 429 LYS   A CB  1 
ATOM   1689 C CG  . LYS   A 1 233 ? -1.72200  -23.01500 -21.42400 1.000 30.19319 ? 429 LYS   A CG  1 
ATOM   1690 C CD  . LYS   A 1 233 ? -1.13200  -23.63600 -22.68700 1.000 37.90350 ? 429 LYS   A CD  1 
ATOM   1691 C CE  . LYS   A 1 233 ? -2.24400  -24.07300 -23.63600 1.000 37.32682 ? 429 LYS   A CE  1 
ATOM   1692 N NZ  . LYS   A 1 233 ? -1.82400  -25.13200 -24.59700 1.000 32.25363 ? 429 LYS   A NZ  1 
ATOM   1693 N N   . MET   A 1 234 ? 1.32300   -22.50900 -17.95700 1.000 25.85216 ? 430 MET   A N   1 
ATOM   1694 C CA  . MET   A 1 234 ? 2.37600   -21.88000 -17.16300 1.000 28.10230 ? 430 MET   A CA  1 
ATOM   1695 C C   . MET   A 1 234 ? 3.62500   -22.75200 -17.11300 1.000 33.54698 ? 430 MET   A C   1 
ATOM   1696 O O   . MET   A 1 234 ? 4.75200   -22.24200 -17.16100 1.000 32.72395 ? 430 MET   A O   1 
ATOM   1697 C CB  . MET   A 1 234 ? 1.88100   -21.59100 -15.74600 1.000 29.22898 ? 430 MET   A CB  1 
ATOM   1698 C CG  . MET   A 1 234 ? 0.89200   -20.44800 -15.64200 1.000 31.32941 ? 430 MET   A CG  1 
ATOM   1699 S SD  . MET   A 1 234 ? 0.06800   -20.44800 -14.04200 1.000 39.00660 ? 430 MET   A SD  1 
ATOM   1700 C CE  . MET   A 1 234 ? 1.24600   -19.49100 -13.08900 1.000 39.47990 ? 430 MET   A CE  1 
ATOM   1701 N N   . ALA   A 1 235 ? 3.44600   -24.07000 -17.00400 1.000 32.87801 ? 431 ALA   A N   1 
ATOM   1702 C CA  . ALA   A 1 235 ? 4.58600   -24.97800 -17.04500 1.000 31.00826 ? 431 ALA   A CA  1 
ATOM   1703 C C   . ALA   A 1 235 ? 5.22600   -24.99900 -18.42800 1.000 29.91357 ? 431 ALA   A C   1 
ATOM   1704 O O   . ALA   A 1 235 ? 6.45800   -25.01400 -18.54800 1.000 35.69657 ? 431 ALA   A O   1 
ATOM   1705 C CB  . ALA   A 1 235 ? 4.14700   -26.38400 -16.63600 1.000 33.10859 ? 431 ALA   A CB  1 
ATOM   1706 N N   . ASP   A 1 236 ? 4.40600   -25.00600 -19.48200 1.000 31.20135 ? 432 ASP   A N   1 
ATOM   1707 C CA  . ASP   A 1 236 ? 4.93900   -24.97900 -20.84200 1.000 33.59587 ? 432 ASP   A CA  1 
ATOM   1708 C C   . ASP   A 1 236 ? 5.76900   -23.72400 -21.08900 1.000 33.62544 ? 432 ASP   A C   1 
ATOM   1709 O O   . ASP   A 1 236 ? 6.76500   -23.76300 -21.82200 1.000 26.51839 ? 432 ASP   A O   1 
ATOM   1710 C CB  . ASP   A 1 236 ? 3.80000   -25.06100 -21.85800 1.000 31.63321 ? 432 ASP   A CB  1 
ATOM   1711 C CG  . ASP   A 1 236 ? 3.01200   -26.35400 -21.76100 1.000 40.16586 ? 432 ASP   A CG  1 
ATOM   1712 O OD1 . ASP   A 1 236 ? 3.45800   -27.28900 -21.06100 1.000 33.18453 ? 432 ASP   A OD1 1 
ATOM   1713 O OD2 . ASP   A 1 236 ? 1.93800   -26.42900 -22.39000 1.000 38.25268 ? 432 ASP   A OD2 1 
ATOM   1714 N N   . LEU   A 1 237 ? 5.36900   -22.59500 -20.49600 1.000 30.42490 ? 433 LEU   A N   1 
ATOM   1715 C CA  . LEU   A 1 237 ? 6.09400   -21.34700 -20.72600 1.000 27.87342 ? 433 LEU   A CA  1 
ATOM   1716 C C   . LEU   A 1 237 ? 7.43900   -21.35200 -20.01600 1.000 29.60474 ? 433 LEU   A C   1 
ATOM   1717 O O   . LEU   A 1 237 ? 8.42300   -20.80800 -20.53200 1.000 29.98146 ? 433 LEU   A O   1 
ATOM   1718 C CB  . LEU   A 1 237 ? 5.25400   -20.15100 -20.27100 1.000 26.92722 ? 433 LEU   A CB  1 
ATOM   1719 C CG  . LEU   A 1 237 ? 4.15900   -19.68900 -21.23000 1.000 27.76937 ? 433 LEU   A CG  1 
ATOM   1720 C CD1 . LEU   A 1 237 ? 3.14700   -18.79700 -20.52100 1.000 28.42625 ? 433 LEU   A CD1 1 
ATOM   1721 C CD2 . LEU   A 1 237 ? 4.77500   -18.96500 -22.41800 1.000 30.40182 ? 433 LEU   A CD2 1 
ATOM   1722 N N   . ARG   A 1 238 ? 7.50400   -21.95600 -18.82700 1.000 29.57340 ? 434 ARG   A N   1 
ATOM   1723 C CA  . ARG   A 1 238 ? 8.77500   -22.04000 -18.11800 1.000 38.25375 ? 434 ARG   A CA  1 
ATOM   1724 C C   . ARG   A 1 238 ? 9.79200   -22.84300 -18.91700 1.000 36.63475 ? 434 ARG   A C   1 
ATOM   1725 O O   . ARG   A 1 238 ? 10.98100  -22.50200 -18.94500 1.000 33.60808 ? 434 ARG   A O   1 
ATOM   1726 C CB  . ARG   A 1 238 ? 8.56000   -22.65300 -16.73600 1.000 35.92877 ? 434 ARG   A CB  1 
ATOM   1727 C CG  . ARG   A 1 238 ? 9.58400   -22.22600 -15.70200 1.000 36.92793 ? 434 ARG   A CG  1 
ATOM   1728 C CD  . ARG   A 1 238 ? 9.35300   -22.95400 -14.39100 1.000 49.79731 ? 434 ARG   A CD  1 
ATOM   1729 N NE  . ARG   A 1 238 ? 8.41200   -22.23900 -13.53400 1.000 43.13514 ? 434 ARG   A NE  1 
ATOM   1730 C CZ  . ARG   A 1 238 ? 8.54500   -22.11100 -12.22100 1.000 48.99903 ? 434 ARG   A CZ  1 
ATOM   1731 N NH1 . ARG   A 1 238 ? 9.57400   -22.63900 -11.57700 1.000 53.52242 ? 434 ARG   A NH1 1 
ATOM   1732 N NH2 . ARG   A 1 238 ? 7.62400   -21.43800 -11.53700 1.000 47.56962 ? 434 ARG   A NH2 1 
ATOM   1733 N N   . GLN   A 1 239 ? 9.33700   -23.90100 -19.59300 1.000 36.09495 ? 435 GLN   A N   1 
ATOM   1734 C CA  . GLN   A 1 239 ? 10.23000  -24.66900 -20.45600 1.000 39.58208 ? 435 GLN   A CA  1 
ATOM   1735 C C   . GLN   A 1 239 ? 10.58500  -23.88800 -21.71500 1.000 39.21057 ? 435 GLN   A C   1 
ATOM   1736 O O   . GLN   A 1 239 ? 11.71700  -23.97100 -22.20400 1.000 38.67405 ? 435 GLN   A O   1 
ATOM   1737 C CB  . GLN   A 1 239 ? 9.58500   -26.00900 -20.81800 1.000 33.17419 ? 435 GLN   A CB  1 
ATOM   1738 C CG  . GLN   A 1 239 ? 10.55400  -27.07100 -21.34800 1.000 47.14814 ? 435 GLN   A CG  1 
ATOM   1739 C CD  . GLN   A 1 239 ? 11.76400  -27.28600 -20.45200 1.000 49.46898 ? 435 GLN   A CD  1 
ATOM   1740 O OE1 . GLN   A 1 239 ? 11.65500  -27.28100 -19.22500 1.000 47.31001 ? 435 GLN   A OE1 1 
ATOM   1741 N NE2 . GLN   A 1 239 ? 12.92900  -27.47700 -21.06600 1.000 47.98124 ? 435 GLN   A NE2 1 
ATOM   1742 N N   . LEU   A 1 240 ? 9.63000   -23.12600 -22.25400 1.000 31.63030 ? 436 LEU   A N   1 
ATOM   1743 C CA  . LEU   A 1 240 ? 9.89200   -22.33200 -23.44900 1.000 30.76494 ? 436 LEU   A CA  1 
ATOM   1744 C C   . LEU   A 1 240 ? 10.93600  -21.25500 -23.18800 1.000 34.71824 ? 436 LEU   A C   1 
ATOM   1745 O O   . LEU   A 1 240 ? 11.70800  -20.90900 -24.08900 1.000 38.08136 ? 436 LEU   A O   1 
ATOM   1746 C CB  . LEU   A 1 240 ? 8.58700   -21.70900 -23.95400 1.000 31.93699 ? 436 LEU   A CB  1 
ATOM   1747 C CG  . LEU   A 1 240 ? 8.58200   -20.99500 -25.30900 1.000 40.21863 ? 436 LEU   A CG  1 
ATOM   1748 C CD1 . LEU   A 1 240 ? 8.54300   -21.99400 -26.45400 1.000 33.83414 ? 436 LEU   A CD1 1 
ATOM   1749 C CD2 . LEU   A 1 240 ? 7.40600   -20.02500 -25.39800 1.000 41.18443 ? 436 LEU   A CD2 1 
ATOM   1750 N N   . VAL   A 1 241 ? 10.98500  -20.72500 -21.96500 1.000 29.90024 ? 437 VAL   A N   1 
ATOM   1751 C CA  . VAL   A 1 241 ? 11.93900  -19.66800 -21.64900 1.000 33.45912 ? 437 VAL   A CA  1 
ATOM   1752 C C   . VAL   A 1 241 ? 13.32500  -20.24700 -21.38800 1.000 35.31586 ? 437 VAL   A C   1 
ATOM   1753 O O   . VAL   A 1 241 ? 14.33400  -19.68200 -21.82200 1.000 39.80550 ? 437 VAL   A O   1 
ATOM   1754 C CB  . VAL   A 1 241 ? 11.43200  -18.83600 -20.45700 1.000 34.29207 ? 437 VAL   A CB  1 
ATOM   1755 C CG1 . VAL   A 1 241 ? 12.52800  -17.91500 -19.93700 1.000 35.28001 ? 437 VAL   A CG1 1 
ATOM   1756 C CG2 . VAL   A 1 241 ? 10.20400  -18.02400 -20.86200 1.000 28.92648 ? 437 VAL   A CG2 1 
ATOM   1757 N N   . THR   A 1 242 ? 13.39800  -21.38300 -20.68800 1.000 39.61229 ? 438 THR   A N   1 
ATOM   1758 C CA  . THR   A 1 242 ? 14.69600  -21.98200 -20.38700 1.000 41.47409 ? 438 THR   A CA  1 
ATOM   1759 C C   . THR   A 1 242 ? 15.42200  -22.38600 -21.66500 1.000 39.40482 ? 438 THR   A C   1 
ATOM   1760 O O   . THR   A 1 242 ? 16.63700  -22.19200 -21.78800 1.000 45.20180 ? 438 THR   A O   1 
ATOM   1761 C CB  . THR   A 1 242 ? 14.52000  -23.18900 -19.46600 1.000 45.56541 ? 438 THR   A CB  1 
ATOM   1762 O OG1 . THR   A 1 242 ? 13.50600  -24.05000 -19.99500 1.000 42.69989 ? 438 THR   A OG1 1 
ATOM   1763 C CG2 . THR   A 1 242 ? 14.10600  -22.73700 -18.07600 1.000 37.57330 ? 438 THR   A CG2 1 
ATOM   1764 N N   . GLU   A 1 243 ? 14.68900  -22.94300 -22.63000 1.000 33.18024 ? 439 GLU   A N   1 
ATOM   1765 C CA  . GLU   A 1 243 ? 15.27700  -23.24500 -23.92800 1.000 39.04799 ? 439 GLU   A CA  1 
ATOM   1766 C C   . GLU   A 1 243 ? 15.62500  -21.97600 -24.69300 1.000 45.03275 ? 439 GLU   A C   1 
ATOM   1767 O O   . GLU   A 1 243 ? 16.58400  -21.96500 -25.47300 1.000 42.62466 ? 439 GLU   A O   1 
ATOM   1768 C CB  . GLU   A 1 243 ? 14.31400  -24.09900 -24.74600 1.000 34.30053 ? 439 GLU   A CB  1 
ATOM   1769 C CG  . GLU   A 1 243 ? 13.93500  -25.40500 -24.07600 1.000 43.65945 ? 439 GLU   A CG  1 
ATOM   1770 C CD  . GLU   A 1 243 ? 12.78000  -26.08600 -24.76600 1.000 46.39244 ? 439 GLU   A CD  1 
ATOM   1771 O OE1 . GLU   A 1 243 ? 12.11100  -25.41900 -25.58400 1.000 48.01485 ? 439 GLU   A OE1 1 
ATOM   1772 O OE2 . GLU   A 1 243 ? 12.53200  -27.28000 -24.48800 1.000 49.01530 ? 439 GLU   A OE2 1 
ATOM   1773 N N   . HIS   A 1 244 ? 14.85400  -20.90600 -24.48900 1.000 40.73634 ? 440 HIS   A N   1 
ATOM   1774 C CA  . HIS   A 1 244 ? 15.12700  -19.64700 -25.17300 1.000 33.89063 ? 440 HIS   A CA  1 
ATOM   1775 C C   . HIS   A 1 244 ? 16.41600  -19.01300 -24.66800 1.000 37.71726 ? 440 HIS   A C   1 
ATOM   1776 O O   . HIS   A 1 244 ? 17.18300  -18.44400 -25.45500 1.000 42.24757 ? 440 HIS   A O   1 
ATOM   1777 C CB  . HIS   A 1 244 ? 13.94300  -18.69600 -24.98700 1.000 40.36332 ? 440 HIS   A CB  1 
ATOM   1778 C CG  . HIS   A 1 244 ? 14.07000  -17.40400 -25.73200 1.000 32.85084 ? 440 HIS   A CG  1 
ATOM   1779 N ND1 . HIS   A 1 244 ? 13.83900  -17.29800 -27.08700 1.000 28.95574 ? 440 HIS   A ND1 1 
ATOM   1780 C CD2 . HIS   A 1 244 ? 14.38600  -16.15800 -25.30700 1.000 35.03714 ? 440 HIS   A CD2 1 
ATOM   1781 C CE1 . HIS   A 1 244 ? 14.01700  -16.04600 -27.46600 1.000 32.92834 ? 440 HIS   A CE1 1 
ATOM   1782 N NE2 . HIS   A 1 244 ? 14.34900  -15.33300 -26.40400 1.000 32.39649 ? 440 HIS   A NE2 1 
ATOM   1783 N N   . ALA   A 1 245 ? 16.67000  -19.10000 -23.35900 1.000 33.27603 ? 441 ALA   A N   1 
ATOM   1784 C CA  . ALA   A 1 245 ? 17.89500  -18.53500 -22.80100 1.000 40.55929 ? 441 ALA   A CA  1 
ATOM   1785 C C   . ALA   A 1 245 ? 19.12800  -19.21800 -23.36700 1.000 40.87211 ? 441 ALA   A C   1 
ATOM   1786 O O   . ALA   A 1 245 ? 20.18700  -18.59100 -23.48700 1.000 41.93513 ? 441 ALA   A O   1 
ATOM   1787 C CB  . ALA   A 1 245 ? 17.88500  -18.65100 -21.27800 1.000 39.38366 ? 441 ALA   A CB  1 
ATOM   1788 N N   . GLN   A 1 246 ? 19.00800  -20.50000 -23.71100 1.000 41.04010 ? 442 GLN   A N   1 
ATOM   1789 C CA  . GLN   A 1 246 ? 20.11200  -21.21100 -24.34300 1.000 47.47300 ? 442 GLN   A CA  1 
ATOM   1790 C C   . GLN   A 1 246 ? 20.48100  -20.56900 -25.67500 1.000 47.89499 ? 442 GLN   A C   1 
ATOM   1791 O O   . GLN   A 1 246 ? 21.66500  -20.46100 -26.01600 1.000 46.82873 ? 442 GLN   A O   1 
ATOM   1792 C CB  . GLN   A 1 246 ? 19.72800  -22.67900 -24.52600 1.000 47.77640 ? 442 GLN   A CB  1 
ATOM   1793 C CG  . GLN   A 1 246 ? 19.80000  -23.48600 -23.23600 1.000 52.32407 ? 442 GLN   A CG  1 
ATOM   1794 C CD  . GLN   A 1 246 ? 19.25200  -24.89300 -23.38700 1.000 56.01766 ? 442 GLN   A CD  1 
ATOM   1795 O OE1 . GLN   A 1 246 ? 18.79300  -25.28400 -24.46100 1.000 58.76805 ? 442 GLN   A OE1 1 
ATOM   1796 N NE2 . GLN   A 1 246 ? 19.28700  -25.65800 -22.30200 1.000 63.13356 ? 442 GLN   A NE2 1 
ATOM   1797 N N   . LEU   A 1 247 ? 19.47500  -20.12200 -26.43400 1.000 44.09891 ? 443 LEU   A N   1 
ATOM   1798 C CA  . LEU   A 1 247 ? 19.73800  -19.43200 -27.69200 1.000 42.33057 ? 443 LEU   A CA  1 
ATOM   1799 C C   . LEU   A 1 247 ? 20.33200  -18.05000 -27.45900 1.000 48.33238 ? 443 LEU   A C   1 
ATOM   1800 O O   . LEU   A 1 247 ? 21.14400  -17.58200 -28.26600 1.000 50.50931 ? 443 LEU   A O   1 
ATOM   1801 C CB  . LEU   A 1 247 ? 18.45100  -19.32100 -28.50600 1.000 40.69415 ? 443 LEU   A CB  1 
ATOM   1802 C CG  . LEU   A 1 247 ? 18.00300  -20.58300 -29.24100 1.000 40.07125 ? 443 LEU   A CG  1 
ATOM   1803 C CD1 . LEU   A 1 247 ? 16.48900  -20.62600 -29.33500 1.000 48.84095 ? 443 LEU   A CD1 1 
ATOM   1804 C CD2 . LEU   A 1 247 ? 18.62600  -20.65700 -30.62800 1.000 50.57429 ? 443 LEU   A CD2 1 
ATOM   1805 N N   . VAL   A 1 248 ? 19.94000  -17.38500 -26.37100 1.000 40.60778 ? 444 VAL   A N   1 
ATOM   1806 C CA  . VAL   A 1 248 ? 20.50800  -16.08000 -26.04900 1.000 40.85560 ? 444 VAL   A CA  1 
ATOM   1807 C C   . VAL   A 1 248 ? 22.00700  -16.20000 -25.79600 1.000 48.24148 ? 444 VAL   A C   1 
ATOM   1808 O O   . VAL   A 1 248 ? 22.79200  -15.34000 -26.21200 1.000 41.30489 ? 444 VAL   A O   1 
ATOM   1809 C CB  . VAL   A 1 248 ? 19.77500  -15.46200 -24.84400 1.000 41.46118 ? 444 VAL   A CB  1 
ATOM   1810 C CG1 . VAL   A 1 248 ? 20.32900  -14.07800 -24.53200 1.000 40.60341 ? 444 VAL   A CG1 1 
ATOM   1811 C CG2 . VAL   A 1 248 ? 18.27400  -15.40000 -25.10800 1.000 37.52087 ? 444 VAL   A CG2 1 
ATOM   1812 N N   . GLN   A 1 249 ? 22.42800  -17.27200 -25.11800 1.000 45.35149 ? 445 GLN   A N   1 
ATOM   1813 C CA  . GLN   A 1 249 ? 23.85200  -17.46000 -24.85600 1.000 45.52271 ? 445 GLN   A CA  1 
ATOM   1814 C C   . GLN   A 1 249 ? 24.60000  -17.88500 -26.11400 1.000 54.85374 ? 445 GLN   A C   1 
ATOM   1815 O O   . GLN   A 1 249 ? 25.76700  -17.51400 -26.29300 1.000 52.57928 ? 445 GLN   A O   1 
ATOM   1816 C CB  . GLN   A 1 249 ? 24.05000  -18.47800 -23.73000 1.000 41.47095 ? 445 GLN   A CB  1 
ATOM   1817 C CG  . GLN   A 1 249 ? 25.48800  -18.95500 -23.53000 1.000 44.58026 ? 445 GLN   A CG  1 
ATOM   1818 C CD  . GLN   A 1 249 ? 26.41100  -17.87600 -22.97200 1.000 49.55980 ? 445 GLN   A CD  1 
ATOM   1819 O OE1 . GLN   A 1 249 ? 25.96200  -16.91200 -22.34900 1.000 44.86595 ? 445 GLN   A OE1 1 
ATOM   1820 N NE2 . GLN   A 1 249 ? 27.71300  -18.04800 -23.18200 1.000 44.81751 ? 445 GLN   A NE2 1 
ATOM   1821 N N   . ILE   A 1 250 ? 23.94900  -18.64900 -26.99700 1.000 49.45490 ? 446 ILE   A N   1 
ATOM   1822 C CA  . ILE   A 1 250 ? 24.55500  -18.99100 -28.28200 1.000 47.40544 ? 446 ILE   A CA  1 
ATOM   1823 C C   . ILE   A 1 250 ? 24.88000  -17.72600 -29.06900 1.000 62.66891 ? 446 ILE   A C   1 
ATOM   1824 O O   . ILE   A 1 250 ? 25.95500  -17.60400 -29.67000 1.000 61.09693 ? 446 ILE   A O   1 
ATOM   1825 C CB  . ILE   A 1 250 ? 23.62300  -19.92500 -29.07800 1.000 50.57814 ? 446 ILE   A CB  1 
ATOM   1826 C CG1 . ILE   A 1 250 ? 23.61000  -21.32500 -28.46500 1.000 49.85955 ? 446 ILE   A CG1 1 
ATOM   1827 C CG2 . ILE   A 1 250 ? 24.04400  -19.98300 -30.54200 1.000 52.76847 ? 446 ILE   A CG2 1 
ATOM   1828 C CD1 . ILE   A 1 250 ? 22.85600  -22.34600 -29.29300 1.000 51.56734 ? 446 ILE   A CD1 1 
ATOM   1829 N N   . ILE   A 1 251 ? 23.96200  -16.76000 -29.06200 1.000 55.86636 ? 447 ILE   A N   1 
ATOM   1830 C CA  . ILE   A 1 251 ? 24.15800  -15.52700 -29.81500 1.000 54.88827 ? 447 ILE   A CA  1 
ATOM   1831 C C   . ILE   A 1 251 ? 25.15000  -14.60700 -29.11100 1.000 58.75854 ? 447 ILE   A C   1 
ATOM   1832 O O   . ILE   A 1 251 ? 25.97300  -13.95200 -29.76100 1.000 59.28249 ? 447 ILE   A O   1 
ATOM   1833 C CB  . ILE   A 1 251 ? 22.79600  -14.84600 -30.04500 1.000 49.50355 ? 447 ILE   A CB  1 
ATOM   1834 C CG1 . ILE   A 1 251 ? 22.03700  -15.55800 -31.16400 1.000 46.77165 ? 447 ILE   A CG1 1 
ATOM   1835 C CG2 . ILE   A 1 251 ? 22.96400  -13.36800 -30.35100 1.000 53.52508 ? 447 ILE   A CG2 1 
ATOM   1836 C CD1 . ILE   A 1 251 ? 20.67500  -14.97400 -31.44200 1.000 56.37266 ? 447 ILE   A CD1 1 
ATOM   1837 N N   . LYS   A 1 252 ? 25.10000  -14.54900 -27.77800 1.000 47.29666 ? 448 LYS   A N   1 
ATOM   1838 C CA  . LYS   A 1 252 ? 26.00500  -13.67100 -27.04100 1.000 54.95673 ? 448 LYS   A CA  1 
ATOM   1839 C C   . LYS   A 1 252 ? 27.46200  -14.05000 -27.28000 1.000 61.33620 ? 448 LYS   A C   1 
ATOM   1840 O O   . LYS   A 1 252 ? 28.32400  -13.17500 -27.42900 1.000 59.88115 ? 448 LYS   A O   1 
ATOM   1841 C CB  . LYS   A 1 252 ? 25.67700  -13.71400 -25.54700 1.000 54.89204 ? 448 LYS   A CB  1 
ATOM   1842 C CG  . LYS   A 1 252 ? 26.87200  -13.46400 -24.63600 1.000 58.82731 ? 448 LYS   A CG  1 
ATOM   1843 C CD  . LYS   A 1 252 ? 26.47000  -12.72800 -23.36600 1.000 60.56177 ? 448 LYS   A CD  1 
ATOM   1844 C CE  . LYS   A 1 252 ? 27.49500  -12.93800 -22.25900 1.000 51.90577 ? 448 LYS   A CE  1 
ATOM   1845 N NZ  . LYS   A 1 252 ? 27.27800  -14.20400 -21.49900 1.000 50.49412 ? 448 LYS   A NZ  1 
ATOM   1846 N N   . LYS   A 1 253 ? 27.75200  -15.34800 -27.34600 1.000 60.06028 ? 449 LYS   A N   1 
ATOM   1847 C CA  . LYS   A 1 253 ? 29.12800  -15.82000 -27.42800 1.000 64.41033 ? 449 LYS   A CA  1 
ATOM   1848 C C   . LYS   A 1 253 ? 29.62800  -15.99000 -28.85700 1.000 68.96022 ? 449 LYS   A C   1 
ATOM   1849 O O   . LYS   A 1 253 ? 30.83800  -15.89200 -29.09200 1.000 70.29924 ? 449 LYS   A O   1 
ATOM   1850 C CB  . LYS   A 1 253 ? 29.26700  -17.15300 -26.68600 1.000 60.88542 ? 449 LYS   A CB  1 
ATOM   1851 C CG  . LYS   A 1 253 ? 30.64600  -17.40600 -26.09700 1.000 57.63829 ? 449 LYS   A CG  1 
ATOM   1852 C CD  . LYS   A 1 253 ? 30.67500  -18.72200 -25.33700 1.000 54.44084 ? 449 LYS   A CD  1 
ATOM   1853 C CE  . LYS   A 1 253 ? 30.39200  -19.89400 -26.26300 1.000 51.19852 ? 449 LYS   A CE  1 
ATOM   1854 N NZ  . LYS   A 1 253 ? 31.60600  -20.35400 -26.98700 1.000 62.61001 ? 449 LYS   A NZ  1 
ATOM   1855 N N   . THR   A 1 254 ? 28.73600  -16.24200 -29.81800 1.000 60.08063 ? 450 THR   A N   1 
ATOM   1856 C CA  . THR   A 1 254 ? 29.14600  -16.60200 -31.17100 1.000 63.59745 ? 450 THR   A CA  1 
ATOM   1857 C C   . THR   A 1 254 ? 28.66300  -15.62700 -32.24000 1.000 69.58916 ? 450 THR   A C   1 
ATOM   1858 O O   . THR   A 1 254 ? 28.82200  -15.91200 -33.43400 1.000 72.11913 ? 450 THR   A O   1 
ATOM   1859 C CB  . THR   A 1 254 ? 28.66000  -18.01400 -31.51600 1.000 64.21824 ? 450 THR   A CB  1 
ATOM   1860 O OG1 . THR   A 1 254 ? 27.25700  -17.97800 -31.80600 1.000 61.94861 ? 450 THR   A OG1 1 
ATOM   1861 C CG2 . THR   A 1 254 ? 28.91200  -18.96800 -30.35700 1.000 64.03569 ? 450 THR   A CG2 1 
ATOM   1862 N N   . GLU   A 1 255 ? 28.07500  -14.49400 -31.85900 1.000 67.79302 ? 451 GLU   A N   1 
ATOM   1863 C CA  . GLU   A 1 255 ? 27.62900  -13.48200 -32.81500 1.000 67.24747 ? 451 GLU   A CA  1 
ATOM   1864 C C   . GLU   A 1 255 ? 28.15300  -12.12800 -32.35400 1.000 67.75955 ? 451 GLU   A C   1 
ATOM   1865 O O   . GLU   A 1 255 ? 27.64900  -11.56400 -31.37800 1.000 72.18620 ? 451 GLU   A O   1 
ATOM   1866 C CB  . GLU   A 1 255 ? 26.10500  -13.46800 -32.94400 1.000 64.91912 ? 451 GLU   A CB  1 
ATOM   1867 C CG  . GLU   A 1 255 ? 25.48900  -14.82600 -33.26000 1.000 60.31572 ? 451 GLU   A CG  1 
ATOM   1868 C CD  . GLU   A 1 255 ? 25.52600  -15.15900 -34.73900 1.000 58.42383 ? 451 GLU   A CD  1 
ATOM   1869 O OE1 . GLU   A 1 255 ? 25.86300  -14.26600 -35.54300 1.000 58.87994 ? 451 GLU   A OE1 1 
ATOM   1870 O OE2 . GLU   A 1 255 ? 25.21900  -16.31700 -35.09600 1.000 61.38439 ? 451 GLU   A OE2 1 
ATOM   1871 N N   . SER   A 1 256 ? 29.15700  -11.60700 -33.06400 1.000 68.44611 ? 452 SER   A N   1 
ATOM   1872 C CA  . SER   A 1 256 ? 29.82500  -10.38300 -32.62900 1.000 73.01945 ? 452 SER   A CA  1 
ATOM   1873 C C   . SER   A 1 256 ? 28.91700  -9.16700  -32.77500 1.000 72.95431 ? 452 SER   A C   1 
ATOM   1874 O O   . SER   A 1 256 ? 28.77400  -8.37000  -31.84000 1.000 69.04380 ? 452 SER   A O   1 
ATOM   1875 C CB  . SER   A 1 256 ? 31.11600  -10.18400 -33.42300 1.000 72.47734 ? 452 SER   A CB  1 
ATOM   1876 O OG  . SER   A 1 256 ? 30.94200  -10.57100 -34.77600 1.000 70.52574 ? 452 SER   A OG  1 
ATOM   1877 N N   . ASP   A 1 257 ? 28.30000  -9.00400  -33.94900 1.000 68.32073 ? 453 ASP   A N   1 
ATOM   1878 C CA  . ASP   A 1 257 ? 27.47000  -7.83200  -34.20300 1.000 65.44598 ? 453 ASP   A CA  1 
ATOM   1879 C C   . ASP   A 1 257 ? 26.15800  -7.86300  -33.43400 1.000 69.04642 ? 453 ASP   A C   1 
ATOM   1880 O O   . ASP   A 1 257 ? 25.49800  -6.82400  -33.32000 1.000 67.47215 ? 453 ASP   A O   1 
ATOM   1881 C CB  . ASP   A 1 257 ? 27.18600  -7.70700  -35.69900 1.000 65.58529 ? 453 ASP   A CB  1 
ATOM   1882 C CG  . ASP   A 1 257 ? 28.34300  -7.09900  -36.45800 1.000 68.42701 ? 453 ASP   A CG  1 
ATOM   1883 O OD1 . ASP   A 1 257 ? 28.80700  -7.72400  -37.43300 1.000 73.68991 ? 453 ASP   A OD1 1 
ATOM   1884 O OD2 . ASP   A 1 257 ? 28.78800  -5.99700  -36.07600 1.000 69.94137 ? 453 ASP   A OD2 1 
ATOM   1885 N N   . ALA   A 1 258 ? 25.76500  -9.02200  -32.90700 1.000 64.31801 ? 454 ALA   A N   1 
ATOM   1886 C CA  . ALA   A 1 258 ? 24.51000  -9.14800  -32.16700 1.000 58.00959 ? 454 ALA   A CA  1 
ATOM   1887 C C   . ALA   A 1 258 ? 24.75500  -8.83200  -30.69100 1.000 55.29672 ? 454 ALA   A C   1 
ATOM   1888 O O   . ALA   A 1 258 ? 24.75700  -9.70100  -29.81800 1.000 57.67710 ? 454 ALA   A O   1 
ATOM   1889 C CB  . ALA   A 1 258 ? 23.91900  -10.53800 -32.35900 1.000 55.46978 ? 454 ALA   A CB  1 
ATOM   1890 N N   . ALA   A 1 259 ? 24.96900  -7.54700  -30.42700 1.000 49.84977 ? 455 ALA   A N   1 
ATOM   1891 C CA  . ALA   A 1 259 ? 25.18300  -7.09300  -29.06100 1.000 57.12340 ? 455 ALA   A CA  1 
ATOM   1892 C C   . ALA   A 1 259 ? 23.90200  -7.22300  -28.24500 1.000 56.09767 ? 455 ALA   A C   1 
ATOM   1893 O O   . ALA   A 1 259 ? 22.79200  -7.04300  -28.75200 1.000 59.84669 ? 455 ALA   A O   1 
ATOM   1894 C CB  . ALA   A 1 259 ? 25.67000  -5.64400  -29.04400 1.000 56.31696 ? 455 ALA   A CB  1 
ATOM   1895 N N   . LEU   A 1 260 ? 24.06900  -7.54600  -26.96700 1.000 54.50585 ? 456 LEU   A N   1 
ATOM   1896 C CA  . LEU   A 1 260 ? 22.94500  -7.73700  -26.06400 1.000 53.41275 ? 456 LEU   A CA  1 
ATOM   1897 C C   . LEU   A 1 260 ? 22.62800  -6.43800  -25.33800 1.000 54.22329 ? 456 LEU   A C   1 
ATOM   1898 O O   . LEU   A 1 260 ? 23.53100  -5.73000  -24.88500 1.000 52.43973 ? 456 LEU   A O   1 
ATOM   1899 C CB  . LEU   A 1 260 ? 23.25400  -8.83800  -25.04900 1.000 54.83437 ? 456 LEU   A CB  1 
ATOM   1900 C CG  . LEU   A 1 260 ? 22.56900  -10.18400 -25.28800 1.000 56.32397 ? 456 LEU   A CG  1 
ATOM   1901 C CD1 . LEU   A 1 260 ? 22.42800  -10.95900 -23.98700 1.000 61.97935 ? 456 LEU   A CD1 1 
ATOM   1902 C CD2 . LEU   A 1 260 ? 21.21900  -9.97900  -25.94200 1.000 57.65576 ? 456 LEU   A CD2 1 
ATOM   1903 N N   . HIS   A 1 261 ? 21.34100  -6.12800  -25.23100 1.000 43.47822 ? 457 HIS   A N   1 
ATOM   1904 C CA  . HIS   A 1 261 ? 20.93800  -4.95000  -24.48100 1.000 45.03490 ? 457 HIS   A CA  1 
ATOM   1905 C C   . HIS   A 1 261 ? 21.27700  -5.14400  -23.00500 1.000 47.39678 ? 457 HIS   A C   1 
ATOM   1906 O O   . HIS   A 1 261 ? 21.07800  -6.23700  -22.46200 1.000 50.08334 ? 457 HIS   A O   1 
ATOM   1907 C CB  . HIS   A 1 261 ? 19.44400  -4.68600  -24.65600 1.000 38.71756 ? 457 HIS   A CB  1 
ATOM   1908 C CG  . HIS   A 1 261 ? 18.99700  -3.35800  -24.13000 1.000 39.18179 ? 457 HIS   A CG  1 
ATOM   1909 N ND1 . HIS   A 1 261 ? 18.92200  -3.07700  -22.78300 1.000 36.17795 ? 457 HIS   A ND1 1 
ATOM   1910 C CD2 . HIS   A 1 261 ? 18.59800  -2.23500  -24.77200 1.000 42.60725 ? 457 HIS   A CD2 1 
ATOM   1911 C CE1 . HIS   A 1 261 ? 18.49600  -1.83700  -22.61700 1.000 42.64250 ? 457 HIS   A CE1 1 
ATOM   1912 N NE2 . HIS   A 1 261 ? 18.29100  -1.30500  -23.80800 1.000 49.09886 ? 457 HIS   A NE2 1 
ATOM   1913 N N   . PRO   A 1 262 ? 21.82500  -4.12100  -22.34200 1.000 49.73757 ? 458 PRO   A N   1 
ATOM   1914 C CA  . PRO   A 1 262 ? 22.18400  -4.26900  -20.91900 1.000 45.89000 ? 458 PRO   A CA  1 
ATOM   1915 C C   . PRO   A 1 262 ? 21.06100  -4.81400  -20.04900 1.000 46.99453 ? 458 PRO   A C   1 
ATOM   1916 O O   . PRO   A 1 262 ? 21.31700  -5.64100  -19.16600 1.000 42.04156 ? 458 PRO   A O   1 
ATOM   1917 C CB  . PRO   A 1 262 ? 22.57100  -2.84200  -20.50100 1.000 49.32525 ? 458 PRO   A CB  1 
ATOM   1918 C CG  . PRO   A 1 262 ? 22.78900  -2.07200  -21.76600 1.000 52.44171 ? 458 PRO   A CG  1 
ATOM   1919 C CD  . PRO   A 1 262 ? 22.39600  -2.90600  -22.94700 1.000 48.41061 ? 458 PRO   A CD  1 
ATOM   1920 N N   . LEU   A 1 263 ? 19.82000  -4.37400  -20.27200 1.000 43.50103 ? 459 LEU   A N   1 
ATOM   1921 C CA  . LEU   A 1 263 ? 18.71500  -4.85700  -19.45100 1.000 43.36440 ? 459 LEU   A CA  1 
ATOM   1922 C C   . LEU   A 1 263 ? 18.45900  -6.33900  -19.68900 1.000 38.07440 ? 459 LEU   A C   1 
ATOM   1923 O O   . LEU   A 1 263 ? 18.18700  -7.08700  -18.74300 1.000 43.64880 ? 459 LEU   A O   1 
ATOM   1924 C CB  . LEU   A 1 263 ? 17.45300  -4.03900  -19.73000 1.000 38.81239 ? 459 LEU   A CB  1 
ATOM   1925 C CG  . LEU   A 1 263 ? 16.16400  -4.50300  -19.04300 1.000 37.57676 ? 459 LEU   A CG  1 
ATOM   1926 C CD1 . LEU   A 1 263 ? 16.24300  -4.29700  -17.53600 1.000 34.04170 ? 459 LEU   A CD1 1 
ATOM   1927 C CD2 . LEU   A 1 263 ? 14.95900  -3.78700  -19.62200 1.000 36.21447 ? 459 LEU   A CD2 1 
ATOM   1928 N N   . LEU   A 1 264 ? 18.55200  -6.78300  -20.94400 1.000 40.17928 ? 460 LEU   A N   1 
ATOM   1929 C CA  . LEU   A 1 264 ? 18.28700  -8.18500  -21.24900 1.000 41.14995 ? 460 LEU   A CA  1 
ATOM   1930 C C   . LEU   A 1 264 ? 19.40700  -9.08000  -20.73700 1.000 46.22198 ? 460 LEU   A C   1 
ATOM   1931 O O   . LEU   A 1 264 ? 19.14500  -10.15800 -20.18900 1.000 36.64572 ? 460 LEU   A O   1 
ATOM   1932 C CB  . LEU   A 1 264 ? 18.09100  -8.36900  -22.75400 1.000 34.60440 ? 460 LEU   A CB  1 
ATOM   1933 C CG  . LEU   A 1 264 ? 16.95000  -7.57700  -23.40200 1.000 38.59040 ? 460 LEU   A CG  1 
ATOM   1934 C CD1 . LEU   A 1 264 ? 16.62300  -8.14700  -24.77000 1.000 33.10721 ? 460 LEU   A CD1 1 
ATOM   1935 C CD2 . LEU   A 1 264 ? 15.70700  -7.55500  -22.52000 1.000 32.43289 ? 460 LEU   A CD2 1 
ATOM   1936 N N   . GLN   A 1 265 ? 20.66300  -8.65300  -20.90000 1.000 43.36851 ? 461 GLN   A N   1 
ATOM   1937 C CA  . GLN   A 1 265 ? 21.76700  -9.43500  -20.35200 1.000 46.11252 ? 461 GLN   A CA  1 
ATOM   1938 C C   . GLN   A 1 265 ? 21.69200  -9.50200  -18.83300 1.000 39.65019 ? 461 GLN   A C   1 
ATOM   1939 O O   . GLN   A 1 265 ? 22.08300  -10.51100 -18.23800 1.000 45.85281 ? 461 GLN   A O   1 
ATOM   1940 C CB  . GLN   A 1 265 ? 23.11200  -8.85700  -20.79700 1.000 51.34146 ? 461 GLN   A CB  1 
ATOM   1941 C CG  . GLN   A 1 265 ? 24.18400  -9.92500  -21.00600 1.000 59.46395 ? 461 GLN   A CG  1 
ATOM   1942 C CD  . GLN   A 1 265 ? 25.54000  -9.34500  -21.36400 1.000 68.41345 ? 461 GLN   A CD  1 
ATOM   1943 O OE1 . GLN   A 1 265 ? 25.72900  -8.80100  -22.45300 1.000 72.08198 ? 461 GLN   A OE1 1 
ATOM   1944 N NE2 . GLN   A 1 265 ? 26.49500  -9.46900  -20.44900 1.000 63.41360 ? 461 GLN   A NE2 1 
ATOM   1945 N N   . GLU   A 1 266 ? 21.19200  -8.44400  -18.19200 1.000 44.59492 ? 462 GLU   A N   1 
ATOM   1946 C CA  . GLU   A 1 266 ? 20.91700  -8.50700  -16.76000 1.000 33.06020 ? 462 GLU   A CA  1 
ATOM   1947 C C   . GLU   A 1 266 ? 19.88500  -9.58300  -16.44900 1.000 46.78429 ? 462 GLU   A C   1 
ATOM   1948 O O   . GLU   A 1 266 ? 20.04400  -10.36100 -15.49900 1.000 40.06300 ? 462 GLU   A O   1 
ATOM   1949 C CB  . GLU   A 1 266 ? 20.43200  -7.15000  -16.25900 1.000 49.21054 ? 462 GLU   A CB  1 
ATOM   1950 C CG  . GLU   A 1 266 ? 19.71400  -7.23500  -14.92700 1.000 52.04254 ? 462 GLU   A CG  1 
ATOM   1951 C CD  . GLU   A 1 266 ? 19.82200  -5.97000  -14.11700 1.000 55.39595 ? 462 GLU   A CD  1 
ATOM   1952 O OE1 . GLU   A 1 266 ? 20.63000  -5.08900  -14.48400 1.000 62.29258 ? 462 GLU   A OE1 1 
ATOM   1953 O OE2 . GLU   A 1 266 ? 19.08500  -5.85400  -13.11600 1.000 52.84903 ? 462 GLU   A OE2 1 
ATOM   1954 N N   . ILE   A 1 267 ? 18.81500  -9.64200  -17.24400 1.000 40.70894 ? 463 ILE   A N   1 
ATOM   1955 C CA  . ILE   A 1 267 ? 17.74200  -10.59600 -16.98100 1.000 39.60536 ? 463 ILE   A CA  1 
ATOM   1956 C C   . ILE   A 1 267 ? 18.22600  -12.02300 -17.21500 1.000 34.84366 ? 463 ILE   A C   1 
ATOM   1957 O O   . ILE   A 1 267 ? 18.03700  -12.90600 -16.37000 1.000 41.12365 ? 463 ILE   A O   1 
ATOM   1958 C CB  . ILE   A 1 267 ? 16.50900  -10.25900 -17.83800 1.000 35.76381 ? 463 ILE   A CB  1 
ATOM   1959 C CG1 . ILE   A 1 267 ? 15.76600  -9.06200  -17.23900 1.000 32.87976 ? 463 ILE   A CG1 1 
ATOM   1960 C CG2 . ILE   A 1 267 ? 15.57900  -11.46000 -17.95700 1.000 29.80566 ? 463 ILE   A CG2 1 
ATOM   1961 C CD1 . ILE   A 1 267 ? 14.96800  -8.27700  -18.24800 1.000 41.72106 ? 463 ILE   A CD1 1 
ATOM   1962 N N   . TYR   A 1 268 ? 18.87200  -12.26900 -18.35700 1.000 35.42632 ? 464 TYR   A N   1 
ATOM   1963 C CA  . TYR   A 1 268 ? 19.32300  -13.61500 -18.69000 1.000 40.47455 ? 464 TYR   A CA  1 
ATOM   1964 C C   . TYR   A 1 268 ? 20.52000  -14.07500 -17.86500 1.000 44.23665 ? 464 TYR   A C   1 
ATOM   1965 O O   . TYR   A 1 268 ? 20.82100  -15.27400 -17.86900 1.000 49.97702 ? 464 TYR   A O   1 
ATOM   1966 C CB  . TYR   A 1 268 ? 19.67100  -13.70100 -20.17600 1.000 40.42824 ? 464 TYR   A CB  1 
ATOM   1967 C CG  . TYR   A 1 268 ? 18.46700  -13.75800 -21.08700 1.000 36.51041 ? 464 TYR   A CG  1 
ATOM   1968 C CD1 . TYR   A 1 268 ? 17.61400  -14.85400 -21.07700 1.000 36.47146 ? 464 TYR   A CD1 1 
ATOM   1969 C CD2 . TYR   A 1 268 ? 18.18300  -12.71200 -21.95500 1.000 42.81325 ? 464 TYR   A CD2 1 
ATOM   1970 C CE1 . TYR   A 1 268 ? 16.51200  -14.90900 -21.91200 1.000 39.06966 ? 464 TYR   A CE1 1 
ATOM   1971 C CE2 . TYR   A 1 268 ? 17.08400  -12.75600 -22.79200 1.000 43.09830 ? 464 TYR   A CE2 1 
ATOM   1972 C CZ  . TYR   A 1 268 ? 16.25300  -13.85500 -22.76600 1.000 35.43240 ? 464 TYR   A CZ  1 
ATOM   1973 O OH  . TYR   A 1 268 ? 15.16500  -13.89600 -23.60200 1.000 39.17144 ? 464 TYR   A OH  1 
ATOM   1974 N N   . ARG   A 1 269 ? 21.20400  -13.17200 -17.16600 1.000 46.60044 ? 465 ARG   A N   1 
ATOM   1975 C CA  . ARG   A 1 269 ? 22.38200  -13.56100 -16.40000 1.000 50.55966 ? 465 ARG   A CA  1 
ATOM   1976 C C   . ARG   A 1 269 ? 21.98300  -14.44700 -15.22800 1.000 47.28180 ? 465 ARG   A C   1 
ATOM   1977 O O   . ARG   A 1 269 ? 21.11800  -14.07900 -14.42700 1.000 53.24302 ? 465 ARG   A O   1 
ATOM   1978 C CB  . ARG   A 1 269 ? 23.12500  -12.32500 -15.89700 1.000 45.15104 ? 465 ARG   A CB  1 
ATOM   1979 C CG  . ARG   A 1 269 ? 24.53700  -12.60600 -15.40400 1.000 47.69484 ? 465 ARG   A CG  1 
ATOM   1980 C CD  . ARG   A 1 269 ? 25.57400  -12.07200 -16.37900 1.000 54.39420 ? 465 ARG   A CD  1 
ATOM   1981 N NE  . ARG   A 1 269 ? 26.93100  -12.18800 -15.85700 1.000 58.19422 ? 465 ARG   A NE  1 
ATOM   1982 C CZ  . ARG   A 1 269 ? 28.02200  -12.23300 -16.61000 1.000 48.70362 ? 465 ARG   A CZ  1 
ATOM   1983 N NH1 . ARG   A 1 269 ? 27.95300  -12.17100 -17.93100 1.000 50.55446 ? 465 ARG   A NH1 1 
ATOM   1984 N NH2 . ARG   A 1 269 ? 29.21100  -12.34200 -16.02400 1.000 46.23711 ? 465 ARG   A NH2 1 
ATOM   1985 N N   . ASP   A 1 270 ? 22.61400  -15.62000 -15.13500 1.000 39.23423 ? 466 ASP   A N   1 
ATOM   1986 C CA  . ASP   A 1 270 ? 22.37300  -16.56700 -14.04600 1.000 49.91075 ? 466 ASP   A CA  1 
ATOM   1987 C C   . ASP   A 1 270 ? 20.90800  -16.99500 -13.98600 1.000 50.95403 ? 466 ASP   A C   1 
ATOM   1988 O O   . ASP   A 1 270 ? 20.33000  -17.13600 -12.90600 1.000 54.08010 ? 466 ASP   A O   1 
ATOM   1989 C CB  . ASP   A 1 270 ? 22.82500  -15.99100 -12.70100 1.000 46.01072 ? 466 ASP   A CB  1 
ATOM   1990 C CG  . ASP   A 1 270 ? 24.27700  -15.55800 -12.71300 1.000 51.49337 ? 466 ASP   A CG  1 
ATOM   1991 O OD1 . ASP   A 1 270 ? 24.55500  -14.37200 -12.43700 1.000 52.46990 ? 466 ASP   A OD1 1 
ATOM   1992 O OD2 . ASP   A 1 270 ? 25.14100  -16.41100 -12.99600 1.000 50.87874 ? 466 ASP   A OD2 1 
ATOM   1993 N N   . MET   A 1 271 ? 20.30400  -17.21500 -15.15100 1.000 50.22023 ? 467 MET   A N   1 
ATOM   1994 C CA  . MET   A 1 271 ? 18.91100  -17.65200 -15.20300 1.000 56.95214 ? 467 MET   A CA  1 
ATOM   1995 C C   . MET   A 1 271 ? 18.71800  -18.71700 -16.27700 1.000 61.38431 ? 467 MET   A C   1 
ATOM   1996 O O   . MET   A 1 271 ? 18.95200  -19.90300 -16.03800 1.000 62.61110 ? 467 MET   A O   1 
ATOM   1997 C CB  . MET   A 1 271 ? 17.97900  -16.46200 -15.46200 1.000 48.14922 ? 467 MET   A CB  1 
ATOM   1998 C CG  . MET   A 1 271 ? 16.52700  -16.84100 -15.74900 1.000 56.75065 ? 467 MET   A CG  1 
ATOM   1999 S SD  . MET   A 1 271 ? 15.78900  -16.11900 -17.23000 1.000 51.40057 ? 467 MET   A SD  1 
ATOM   2000 C CE  . MET   A 1 271 ? 16.26300  -17.30600 -18.47400 1.000 35.42870 ? 467 MET   A CE  1 
ATOM   2001 N N   . SER   B 2 8   ? 21.56600  -2.34500  -10.44100 1.000 53.68391 ? 142 SER   B N   1 
ATOM   2002 C CA  . SER   B 2 8   ? 21.03900  -3.12200  -11.53800 1.000 49.77684 ? 142 SER   B CA  1 
ATOM   2003 C C   . SER   B 2 8   ? 19.94600  -2.34500  -12.20400 1.000 44.75481 ? 142 SER   B C   1 
ATOM   2004 O O   . SER   B 2 8   ? 19.28900  -1.57700  -11.56300 1.000 50.06558 ? 142 SER   B O   1 
ATOM   2005 C CB  . SER   B 2 8   ? 20.50900  -4.45600  -11.05100 1.000 59.09054 ? 142 SER   B CB  1 
ATOM   2006 O OG  . SER   B 2 8   ? 19.13000  -4.40300  -10.74700 1.000 52.82528 ? 142 SER   B OG  1 
ATOM   2007 N N   . LEU   B 2 9   ? 19.76100  -2.53800  -13.49100 1.000 46.42911 ? 143 LEU   B N   1 
ATOM   2008 C CA  . LEU   B 2 9   ? 18.71300  -1.83100  -14.19600 1.000 46.62665 ? 143 LEU   B CA  1 
ATOM   2009 C C   . LEU   B 2 9   ? 17.30800  -2.20800  -13.71300 1.000 48.90595 ? 143 LEU   B C   1 
ATOM   2010 O O   . LEU   B 2 9   ? 16.44100  -1.37600  -13.64400 1.000 44.27721 ? 143 LEU   B O   1 
ATOM   2011 C CB  . LEU   B 2 9   ? 18.84600  -2.03300  -15.68600 1.000 44.12187 ? 143 LEU   B CB  1 
ATOM   2012 C CG  . LEU   B 2 9   ? 20.29600  -2.06000  -16.15900 1.000 52.85040 ? 143 LEU   B CG  1 
ATOM   2013 C CD1 . LEU   B 2 9   ? 20.52000  -2.76900  -17.47900 1.000 50.59009 ? 143 LEU   B CD1 1 
ATOM   2014 C CD2 . LEU   B 2 9   ? 20.90300  -0.67900  -16.17300 1.000 56.61038 ? 143 LEU   B CD2 1 
ATOM   2015 N N   . LEU   B 2 10  ? 17.08700  -3.47700  -13.40900 1.000 49.06420 ? 144 LEU   B N   1 
ATOM   2016 C CA  . LEU   B 2 10  ? 15.77700  -3.88500  -12.90600 1.000 44.35200 ? 144 LEU   B CA  1 
ATOM   2017 C C   . LEU   B 2 10  ? 15.43900  -3.15300  -11.61400 1.000 46.10500 ? 144 LEU   B C   1 
ATOM   2018 O O   . LEU   B 2 10  ? 14.29000  -2.75100  -11.40000 1.000 44.26913 ? 144 LEU   B O   1 
ATOM   2019 C CB  . LEU   B 2 10  ? 15.73100  -5.39900  -12.68900 1.000 45.29707 ? 144 LEU   B CB  1 
ATOM   2020 C CG  . LEU   B 2 10  ? 15.51100  -6.27600  -13.92200 1.000 44.17185 ? 144 LEU   B CG  1 
ATOM   2021 C CD1 . LEU   B 2 10  ? 16.07800  -7.67400  -13.69900 1.000 48.24414 ? 144 LEU   B CD1 1 
ATOM   2022 C CD2 . LEU   B 2 10  ? 14.03100  -6.34400  -14.27200 1.000 42.83889 ? 144 LEU   B CD2 1 
ATOM   2023 N N   . LYS   B 2 11  ? 16.43000  -2.97700  -10.73800 1.000 47.66428 ? 145 LYS   B N   1 
ATOM   2024 C CA  . LYS   B 2 11  ? 16.23200  -2.14300  -9.55800  1.000 49.12971 ? 145 LYS   B CA  1 
ATOM   2025 C C   . LYS   B 2 11  ? 15.88600  -0.71500  -9.95900  1.000 45.68463 ? 145 LYS   B C   1 
ATOM   2026 O O   . LYS   B 2 11  ? 15.01000  -0.08600  -9.35500  1.000 49.28839 ? 145 LYS   B O   1 
ATOM   2027 C CB  . LYS   B 2 11  ? 17.48900  -2.17100  -8.68900  1.000 51.64683 ? 145 LYS   B CB  1 
ATOM   2028 C CG  . LYS   B 2 11  ? 17.46500  -3.20200  -7.57700  1.000 45.33419 ? 145 LYS   B CG  1 
ATOM   2029 C CD  . LYS   B 2 11  ? 18.39600  -2.80400  -6.44300  1.000 52.44694 ? 145 LYS   B CD  1 
ATOM   2030 C CE  . LYS   B 2 11  ? 19.36300  -3.92700  -6.10500  1.000 65.12124 ? 145 LYS   B CE  1 
ATOM   2031 N NZ  . LYS   B 2 11  ? 18.70700  -4.98400  -5.28500  1.000 58.01977 ? 145 LYS   B NZ  1 
ATOM   2032 N N   . LYS   B 2 12  ? 16.55700  -0.19600  -10.99000 1.000 44.61426 ? 146 LYS   B N   1 
ATOM   2033 C CA  . LYS   B 2 12  ? 16.28800  1.16100   -11.45500 1.000 51.34061 ? 146 LYS   B CA  1 
ATOM   2034 C C   . LYS   B 2 12  ? 14.86400  1.29100   -11.98300 1.000 50.76837 ? 146 LYS   B C   1 
ATOM   2035 O O   . LYS   B 2 12  ? 14.21100  2.32300   -11.78500 1.000 49.13026 ? 146 LYS   B O   1 
ATOM   2036 C CB  . LYS   B 2 12  ? 17.30200  1.55000   -12.53200 1.000 53.08668 ? 146 LYS   B CB  1 
ATOM   2037 C CG  . LYS   B 2 12  ? 17.34500  3.03400   -12.85100 1.000 60.50050 ? 146 LYS   B CG  1 
ATOM   2038 C CD  . LYS   B 2 12  ? 18.48700  3.35500   -13.80700 1.000 62.34143 ? 146 LYS   B CD  1 
ATOM   2039 C CE  . LYS   B 2 12  ? 18.03700  4.29000   -14.92100 1.000 72.90622 ? 146 LYS   B CE  1 
ATOM   2040 N NZ  . LYS   B 2 12  ? 16.65000  3.99300   -15.37600 1.000 66.08657 ? 146 LYS   B NZ  1 
ATOM   2041 N N   . LEU   B 2 13  ? 14.36400  0.25000   -12.65300 1.000 47.40254 ? 147 LEU   B N   1 
ATOM   2042 C CA  . LEU   B 2 13  ? 12.98600  0.26700   -13.13100 1.000 41.40580 ? 147 LEU   B CA  1 
ATOM   2043 C C   . LEU   B 2 13  ? 12.00000  0.25200   -11.97100 1.000 42.86670 ? 147 LEU   B C   1 
ATOM   2044 O O   . LEU   B 2 13  ? 10.97400  0.94100   -12.01200 1.000 42.65304 ? 147 LEU   B O   1 
ATOM   2045 C CB  . LEU   B 2 13  ? 12.74000  -0.92500  -14.05500 1.000 39.84662 ? 147 LEU   B CB  1 
ATOM   2046 C CG  . LEU   B 2 13  ? 13.52000  -0.93400  -15.37000 1.000 41.01302 ? 147 LEU   B CG  1 
ATOM   2047 C CD1 . LEU   B 2 13  ? 13.09900  -2.11700  -16.23400 1.000 39.78290 ? 147 LEU   B CD1 1 
ATOM   2048 C CD2 . LEU   B 2 13  ? 13.33000  0.37700   -16.11600 1.000 45.59770 ? 147 LEU   B CD2 1 
ATOM   2049 N N   . LEU   B 2 14  ? 12.29400  -0.52000  -10.92700 1.000 44.19251 ? 148 LEU   B N   1 
ATOM   2050 C CA  . LEU   B 2 14  ? 11.36700  -0.67200  -9.81400  1.000 46.02861 ? 148 LEU   B CA  1 
ATOM   2051 C C   . LEU   B 2 14  ? 11.38100  0.50500   -8.84900  1.000 51.21551 ? 148 LEU   B C   1 
ATOM   2052 O O   . LEU   B 2 14  ? 10.46400  0.61800   -8.03000  1.000 45.11399 ? 148 LEU   B O   1 
ATOM   2053 C CB  . LEU   B 2 14  ? 11.66600  -1.96600  -9.05700  1.000 44.60059 ? 148 LEU   B CB  1 
ATOM   2054 C CG  . LEU   B 2 14  ? 11.31700  -3.23000  -9.84300  1.000 41.67739 ? 148 LEU   B CG  1 
ATOM   2055 C CD1 . LEU   B 2 14  ? 12.11300  -4.42200  -9.34300  1.000 41.05930 ? 148 LEU   B CD1 1 
ATOM   2056 C CD2 . LEU   B 2 14  ? 9.82300   -3.49500  -9.74900  1.000 43.02956 ? 148 LEU   B CD2 1 
ATOM   2057 N N   . LEU   B 2 15  ? 12.38600  1.37900   -8.91700  1.000 51.88950 ? 149 LEU   B N   1 
ATOM   2058 C CA  . LEU   B 2 15  ? 12.44300  2.57100   -8.08100  1.000 57.54020 ? 149 LEU   B CA  1 
ATOM   2059 C C   . LEU   B 2 15  ? 11.99200  3.82300   -8.82700  1.000 59.64691 ? 149 LEU   B C   1 
ATOM   2060 O O   . LEU   B 2 15  ? 12.43200  4.93200   -8.50300  1.000 66.40664 ? 149 LEU   B O   1 
ATOM   2061 C CB  . LEU   B 2 15  ? 13.85400  2.76400   -7.52600  1.000 50.42867 ? 149 LEU   B CB  1 
ATOM   2062 C CG  . LEU   B 2 15  ? 14.41900  1.63300   -6.66600  1.000 51.01101 ? 149 LEU   B CG  1 
ATOM   2063 C CD1 . LEU   B 2 15  ? 15.93700  1.60200   -6.76000  1.000 46.63249 ? 149 LEU   B CD1 1 
ATOM   2064 C CD2 . LEU   B 2 15  ? 13.96900  1.78400   -5.22300  1.000 52.17986 ? 149 LEU   B CD2 1 
ATOM   2065 N N   . ALA   B 2 16  ? 11.12000  3.66800   -9.81900  1.000 56.06724 ? 150 ALA   B N   1 
ATOM   2066 C CA  . ALA   B 2 16  ? 10.66100  4.79600   -10.62400 1.000 60.75071 ? 150 ALA   B CA  1 
ATOM   2067 C C   . ALA   B 2 16  ? 9.81000   5.75900   -9.80200  1.000 67.08255 ? 150 ALA   B C   1 
ATOM   2068 O O   . ALA   B 2 16  ? 10.03900  6.97000   -9.81500  1.000 65.57282 ? 150 ALA   B O   1 
ATOM   2069 C CB  . ALA   B 2 16  ? 9.88200   4.30000   -11.83200 1.000 57.15594 ? 150 ALA   B CB  1 
HETATM 2070 C C01 . A1LZX C 3 .   ? 11.65300  -12.26800 -29.48400 1.000 34.77813 ? 500 A1LZX A C01 1 
HETATM 2071 C C02 . A1LZX C 3 .   ? 12.17500  -12.11600 -28.19600 1.000 34.87548 ? 500 A1LZX A C02 1 
HETATM 2072 C C03 . A1LZX C 3 .   ? 13.55100  -12.23700 -27.98100 1.000 31.48160 ? 500 A1LZX A C03 1 
HETATM 2073 C C04 . A1LZX C 3 .   ? 14.37400  -12.50900 -29.08100 1.000 31.93748 ? 500 A1LZX A C04 1 
HETATM 2074 C C05 . A1LZX C 3 .   ? 13.77600  -12.64700 -30.34000 1.000 34.05895 ? 500 A1LZX A C05 1 
HETATM 2075 C C06 . A1LZX C 3 .   ? 15.77800  -12.69900 -29.33200 1.000 34.28245 ? 500 A1LZX A C06 1 
HETATM 2076 C C07 . A1LZX C 3 .   ? 10.14500  -12.14600 -29.70600 1.000 32.30543 ? 500 A1LZX A C07 1 
HETATM 2077 C C08 . A1LZX C 3 .   ? 14.11300  -12.05700 -26.57800 1.000 36.49126 ? 500 A1LZX A C08 1 
HETATM 2078 C C09 . A1LZX C 3 .   ? 16.91200  -12.66700 -28.30400 1.000 35.89109 ? 500 A1LZX A C09 1 
HETATM 2079 C C10 . A1LZX C 3 .   ? 18.05300  -13.63400 -28.63500 1.000 40.18189 ? 500 A1LZX A C10 1 
HETATM 2080 C C11 . A1LZX C 3 .   ? 17.42900  -11.26000 -28.03000 1.000 36.65823 ? 500 A1LZX A C11 1 
HETATM 2081 C C12 . A1LZX C 3 .   ? 17.58600  -15.07200 -28.87100 1.000 40.01031 ? 500 A1LZX A C12 1 
HETATM 2082 C C13 . A1LZX C 3 .   ? 17.96900  -11.15700 -26.60700 1.000 39.45506 ? 500 A1LZX A C13 1 
HETATM 2083 C C14 . A1LZX C 3 .   ? 15.69500  -12.70700 -33.42700 1.000 37.97301 ? 500 A1LZX A C14 1 
HETATM 2084 C C15 . A1LZX C 3 .   ? 15.64800  -12.84600 -34.80000 1.000 35.35001 ? 500 A1LZX A C15 1 
HETATM 2085 C C16 . A1LZX C 3 .   ? 14.51700  -13.36600 -35.39300 1.000 39.89099 ? 500 A1LZX A C16 1 
HETATM 2086 C C17 . A1LZX C 3 .   ? 13.43200  -13.74500 -34.61400 1.000 37.16433 ? 500 A1LZX A C17 1 
HETATM 2087 C C18 . A1LZX C 3 .   ? 13.48100  -13.60600 -33.23400 1.000 32.97851 ? 500 A1LZX A C18 1 
HETATM 2088 C C19 . A1LZX C 3 .   ? 14.62100  -13.09400 -32.64200 1.000 33.91710 ? 500 A1LZX A C19 1 
HETATM 2089 C C26 . A1LZX C 3 .   ? 9.76600   -11.19800 -30.84200 1.000 36.07290 ? 500 A1LZX A C26 1 
HETATM 2090 C C28 . A1LZX C 3 .   ? 9.27000   -8.93700  -31.22200 1.000 42.27720 ? 500 A1LZX A C28 1 
HETATM 2091 C C29 . A1LZX C 3 .   ? 7.79200   -9.23600  -31.47800 1.000 37.57852 ? 500 A1LZX A C29 1 
HETATM 2092 F F20 . A1LZX C 3 .   ? 14.47800  -13.50000 -36.74800 1.000 40.57516 ? 500 A1LZX A F20 1 
HETATM 2093 N N21 . A1LZX C 3 .   ? 12.45500  -12.52600 -30.50600 1.000 32.10943 ? 500 A1LZX A N21 1 
HETATM 2094 N N22 . A1LZX C 3 .   ? 15.93100  -12.92500 -30.60900 1.000 34.04438 ? 500 A1LZX A N22 1 
HETATM 2095 N N23 . A1LZX C 3 .   ? 14.75500  -12.90300 -31.21300 1.000 37.16763 ? 500 A1LZX A N23 1 
HETATM 2096 O O24 . A1LZX C 3 .   ? 14.71000  -12.99500 -25.99000 1.000 41.62060 ? 500 A1LZX A O24 1 
HETATM 2097 O O25 . A1LZX C 3 .   ? 13.97200  -10.93700 -26.01700 1.000 34.29061 ? 500 A1LZX A O25 1 
HETATM 2098 O O27 . A1LZX C 3 .   ? 9.78000   -9.89600  -30.33500 1.000 36.26583 ? 500 A1LZX A O27 1 
HETATM 2099 O O   . HOH   D 4 .   ? -10.56100 -22.65700 -29.88100 1.000 49.96039 ? 601 HOH   A O   1 
HETATM 2100 O O   . HOH   D 4 .   ? 4.50800   -28.34200 -19.28200 1.000 45.20043 ? 602 HOH   A O   1 
HETATM 2101 O O   . HOH   D 4 .   ? 19.58800  3.11300   -37.52900 1.000 59.13508 ? 603 HOH   A O   1 
HETATM 2102 O O   . HOH   D 4 .   ? 19.72300  -21.90800 -16.97000 1.000 56.05105 ? 604 HOH   A O   1 
HETATM 2103 O O   . HOH   D 4 .   ? -5.35200  -1.20700  -11.46500 1.000 40.95543 ? 605 HOH   A O   1 
HETATM 2104 O O   . HOH   D 4 .   ? 12.15700  -23.85600 -27.48100 1.000 43.02885 ? 606 HOH   A O   1 
HETATM 2105 O O   . HOH   D 4 .   ? 1.68500   -3.17500  -5.68600  1.000 37.14141 ? 607 HOH   A O   1 
HETATM 2106 O O   . HOH   D 4 .   ? -0.06700  -7.37100  -24.55900 1.000 31.97493 ? 608 HOH   A O   1 
HETATM 2107 O O   . HOH   D 4 .   ? 13.28700  -18.90600 -2.20300  1.000 44.36644 ? 609 HOH   A O   1 
HETATM 2108 O O   . HOH   D 4 .   ? 29.71700  -12.65600 -35.43000 1.000 59.90941 ? 610 HOH   A O   1 
HETATM 2109 O O   . HOH   D 4 .   ? 11.24400  -19.56600 -4.24700  1.000 39.79720 ? 611 HOH   A O   1 
HETATM 2110 O O   . HOH   D 4 .   ? -4.28900  -15.31400 -26.60500 1.000 28.27347 ? 612 HOH   A O   1 
HETATM 2111 O O   . HOH   D 4 .   ? 1.88500   -25.09300 -13.80200 1.000 43.84890 ? 613 HOH   A O   1 
HETATM 2112 O O   . HOH   D 4 .   ? -21.17700 -16.61300 -17.06100 1.000 45.29554 ? 614 HOH   A O   1 
HETATM 2113 O O   . HOH   D 4 .   ? -13.99400 -22.14900 -16.98400 1.000 38.33530 ? 615 HOH   A O   1 
HETATM 2114 O O   . HOH   D 4 .   ? 11.07800  -18.60200 -16.56100 1.000 39.59804 ? 616 HOH   A O   1 
HETATM 2115 O O   . HOH   D 4 .   ? 7.98300   -14.32900 -11.35200 1.000 26.89033 ? 617 HOH   A O   1 
HETATM 2116 O O   . HOH   D 4 .   ? 14.98300  -12.58000 -3.93100  1.000 41.27676 ? 618 HOH   A O   1 
HETATM 2117 O O   . HOH   D 4 .   ? -12.311   -21.933   -12.744   1.000 37.73029 ? 619 HOH   A O   1 
HETATM 2118 O O   . HOH   D 4 .   ? 7.09700   -8.06400  -26.56000 1.000 28.44796 ? 620 HOH   A O   1 
HETATM 2119 O O   . HOH   D 4 .   ? 1.37700   -25.76400 -31.76200 1.000 44.55287 ? 621 HOH   A O   1 
HETATM 2120 O O   . HOH   D 4 .   ? -3.11900  -26.87000 -21.58800 1.000 38.53246 ? 622 HOH   A O   1 
HETATM 2121 O O   . HOH   D 4 .   ? -14.19300 -13.60700 -24.12300 1.000 46.86147 ? 623 HOH   A O   1 
HETATM 2122 O O   . HOH   D 4 .   ? -3.29700  -2.69400  -22.74300 1.000 32.28530 ? 624 HOH   A O   1 
HETATM 2123 O O   . HOH   D 4 .   ? -9.77500  -8.97200  -25.20800 1.000 36.91140 ? 625 HOH   A O   1 
HETATM 2124 O O   . HOH   D 4 .   ? 27.62600  -10.99000 -35.58700 1.000 66.65318 ? 626 HOH   A O   1 
HETATM 2125 O O   . HOH   D 4 .   ? 5.98200   -20.42100 -14.40800 1.000 45.81110 ? 627 HOH   A O   1 
HETATM 2126 O O   . HOH   D 4 .   ? -1.74100  -9.88200  -24.51100 1.000 32.16941 ? 628 HOH   A O   1 
HETATM 2127 O O   . HOH   D 4 .   ? 5.07200   -6.88600  -31.63400 1.000 36.88522 ? 629 HOH   A O   1 
HETATM 2128 O O   . HOH   D 4 .   ? -9.34700  -18.18900 -32.74600 1.000 52.08506 ? 630 HOH   A O   1 
HETATM 2129 O O   . HOH   D 4 .   ? 12.01300  -21.30200 -26.73200 1.000 37.82678 ? 631 HOH   A O   1 
HETATM 2130 O O   . HOH   D 4 .   ? 8.09800   -5.39000  -32.58800 1.000 43.39839 ? 632 HOH   A O   1 
HETATM 2131 O O   . HOH   D 4 .   ? 20.75000  -1.71900  -43.97600 1.000 55.69337 ? 633 HOH   A O   1 
HETATM 2132 O O   . HOH   D 4 .   ? -2.28600  -13.94400 -25.36600 1.000 24.63142 ? 634 HOH   A O   1 
HETATM 2133 O O   . HOH   D 4 .   ? -9.71500  -5.31200  -23.59800 1.000 44.36255 ? 635 HOH   A O   1 
HETATM 2134 O O   . HOH   D 4 .   ? 14.06200  -14.88600 -47.53100 1.000 53.95190 ? 636 HOH   A O   1 
HETATM 2135 O O   . HOH   D 4 .   ? -11.59700 -25.17900 -14.57800 1.000 41.40918 ? 637 HOH   A O   1 
HETATM 2136 O O   . HOH   D 4 .   ? 12.222    1.674     -28.743   1.000 51.24756 ? 638 HOH   A O   1 
HETATM 2137 O O   . HOH   D 4 .   ? -10.27800 -13.34100 -27.43900 1.000 45.99447 ? 639 HOH   A O   1 
HETATM 2138 O O   . HOH   D 4 .   ? -11.87300 -21.91200 -23.96300 1.000 40.41274 ? 640 HOH   A O   1 
HETATM 2139 O O   . HOH   D 4 .   ? 16.93800  -14.56900 -6.80200  1.000 49.87531 ? 641 HOH   A O   1 
HETATM 2140 O O   . HOH   D 4 .   ? 5.76500   -3.79400  -25.82200 1.000 39.55260 ? 642 HOH   A O   1 
HETATM 2141 O O   . HOH   D 4 .   ? -12.69000 -3.86300  -21.78800 1.000 52.66612 ? 643 HOH   A O   1 
HETATM 2142 O O   . HOH   D 4 .   ? 4.32800   -0.39800  0.22200   1.000 57.86117 ? 644 HOH   A O   1 
HETATM 2143 O O   . HOH   D 4 .   ? -17.25200 -17.41900 -10.72000 1.000 42.28090 ? 645 HOH   A O   1 
HETATM 2144 O O   . HOH   D 4 .   ? -4.597    -19.153   4.483     1.000 54.74975 ? 646 HOH   A O   1 
HETATM 2145 O O   . HOH   D 4 .   ? 9.35000   -9.17000  -27.52500 1.000 30.23099 ? 647 HOH   A O   1 
HETATM 2146 O O   . HOH   D 4 .   ? -7.82200  -16.37800 -29.32000 1.000 39.60217 ? 648 HOH   A O   1 
HETATM 2147 O O   . HOH   D 4 .   ? 13.77700  -10.01000 -51.19000 1.000 51.66964 ? 649 HOH   A O   1 
HETATM 2148 O O   . HOH   D 4 .   ? 9.35900   -9.78200  0.42600   1.000 45.90113 ? 650 HOH   A O   1 
HETATM 2149 O O   . HOH   D 4 .   ? -4.95100  -20.75000 -32.75900 1.000 50.72541 ? 651 HOH   A O   1 
HETATM 2150 O O   . HOH   D 4 .   ? 4.81100   -17.11600 -27.80600 1.000 39.52856 ? 652 HOH   A O   1 
HETATM 2151 O O   . HOH   D 4 .   ? 14.94800  -4.30600  -38.33700 1.000 49.75084 ? 653 HOH   A O   1 
HETATM 2152 O O   . HOH   D 4 .   ? 10.70500  -20.25700 -45.32400 1.000 45.25641 ? 654 HOH   A O   1 
HETATM 2153 O O   . HOH   D 4 .   ? -14.03100 -11.51600 -12.51000 1.000 43.45760 ? 655 HOH   A O   1 
HETATM 2154 O O   . HOH   D 4 .   ? 6.49500   -24.64400 -28.11800 1.000 34.28001 ? 656 HOH   A O   1 
HETATM 2155 O O   . HOH   D 4 .   ? 4.83100   -9.69700  -25.40400 1.000 25.47118 ? 657 HOH   A O   1 
HETATM 2156 O O   . HOH   D 4 .   ? 5.82400   -3.68700  -31.03500 1.000 37.28269 ? 658 HOH   A O   1 
HETATM 2157 O O   . HOH   D 4 .   ? 25.02900  -6.03700  -22.11300 1.000 55.51340 ? 659 HOH   A O   1 
HETATM 2158 O O   . HOH   D 4 .   ? -6.08100  -20.34900 -5.25200  1.000 43.19315 ? 660 HOH   A O   1 
HETATM 2159 O O   . HOH   D 4 .   ? 12.16400  -14.12200 -17.64800 1.000 26.70069 ? 661 HOH   A O   1 
HETATM 2160 O O   . HOH   D 4 .   ? 0.33500   -23.55900 -25.77500 1.000 42.47425 ? 662 HOH   A O   1 
HETATM 2161 O O   . HOH   D 4 .   ? -13.16300 -7.54400  -9.99800  1.000 41.86889 ? 663 HOH   A O   1 
HETATM 2162 O O   . HOH   D 4 .   ? -11.89100 -9.95300  -8.12500  1.000 40.88852 ? 664 HOH   A O   1 
HETATM 2163 O O   . HOH   D 4 .   ? 3.27700   1.39100   -18.95600 1.000 45.79420 ? 665 HOH   A O   1 
HETATM 2164 O O   . HOH   D 4 .   ? -6.18700  -17.20400 -25.81400 1.000 30.76296 ? 666 HOH   A O   1 
HETATM 2165 O O   . HOH   D 4 .   ? 1.37700   -24.02600 -36.09700 1.000 54.23491 ? 667 HOH   A O   1 
HETATM 2166 O O   . HOH   D 4 .   ? 6.88100   -25.60600 -24.06200 1.000 36.96079 ? 668 HOH   A O   1 
HETATM 2167 O O   . HOH   D 4 .   ? -20.20900 -26.24500 -19.83100 1.000 51.00140 ? 669 HOH   A O   1 
HETATM 2168 O O   . HOH   D 4 .   ? 5.80500   -15.00000 -46.64800 1.000 48.46416 ? 670 HOH   A O   1 
HETATM 2169 O O   . HOH   D 4 .   ? 2.95900   -4.85500  -32.46400 1.000 35.55996 ? 671 HOH   A O   1 
HETATM 2170 O O   . HOH   D 4 .   ? 4.08000   -5.66100  -48.51700 1.000 56.25914 ? 672 HOH   A O   1 
HETATM 2171 O O   . HOH   D 4 .   ? 11.43200  -20.09900 -12.17500 1.000 34.06425 ? 673 HOH   A O   1 
HETATM 2172 O O   . HOH   D 4 .   ? -19.08800 -22.84300 -26.59500 1.000 54.31687 ? 674 HOH   A O   1 
HETATM 2173 O O   . HOH   D 4 .   ? 0.06300   -8.47400  -26.70700 1.000 42.66794 ? 675 HOH   A O   1 
HETATM 2174 O O   . HOH   D 4 .   ? -4.14000  -18.04900 -33.57000 1.000 38.79656 ? 676 HOH   A O   1 
HETATM 2175 O O   . HOH   D 4 .   ? -14.46700 -5.54200  -8.56800  1.000 51.90867 ? 677 HOH   A O   1 
HETATM 2176 O O   . HOH   D 4 .   ? 9.63900   -18.89700 -37.41400 1.000 43.56829 ? 678 HOH   A O   1 
HETATM 2177 O O   . HOH   D 4 .   ? 18.54600  -14.42800 -2.32600  1.000 48.02614 ? 679 HOH   A O   1 
HETATM 2178 O O   . HOH   D 4 .   ? 20.95600  -17.66700 -19.81300 1.000 54.70135 ? 680 HOH   A O   1 
HETATM 2179 O O   . HOH   D 4 .   ? 11.71200  6.66600   -38.93300 1.000 43.83292 ? 681 HOH   A O   1 
HETATM 2180 O O   . HOH   D 4 .   ? -12.91300 -12.93400 -10.45000 1.000 41.33029 ? 682 HOH   A O   1 
HETATM 2181 O O   . HOH   D 4 .   ? -3.39000  -11.48800 -3.91800  1.000 37.76878 ? 683 HOH   A O   1 
HETATM 2182 O O   . HOH   D 4 .   ? 0.89000   -20.62400 -4.16500  1.000 48.10891 ? 684 HOH   A O   1 
HETATM 2183 O O   . HOH   D 4 .   ? -11.56900 -8.61600  -22.15300 1.000 37.21423 ? 685 HOH   A O   1 
HETATM 2184 O O   . HOH   D 4 .   ? -9.92800  -9.54200  -15.02800 1.000 33.41758 ? 686 HOH   A O   1 
HETATM 2185 O O   . HOH   D 4 .   ? -12.19700 -23.07600 -15.31800 1.000 35.21742 ? 687 HOH   A O   1 
HETATM 2186 O O   . HOH   D 4 .   ? 21.58200  -1.76400  -39.10600 1.000 51.62539 ? 688 HOH   A O   1 
HETATM 2187 O O   . HOH   D 4 .   ? 26.75000  -10.28100 -37.77700 1.000 59.14859 ? 689 HOH   A O   1 
HETATM 2188 O O   . HOH   D 4 .   ? 4.50400   -21.79500 -5.15500  1.000 54.62674 ? 690 HOH   A O   1 
HETATM 2189 O O   . HOH   D 4 .   ? -13.73200 -8.11300  -12.55200 1.000 49.93691 ? 691 HOH   A O   1 
HETATM 2190 O O   . HOH   D 4 .   ? 22.16400  -18.68700 -17.81300 1.000 58.14523 ? 692 HOH   A O   1 
HETATM 2191 O O   . HOH   D 4 .   ? 3.08900   -8.51700  -27.07400 1.000 41.89348 ? 693 HOH   A O   1 
HETATM 2192 O O   . HOH   D 4 .   ? -0.84100  -23.43100 -37.83400 1.000 45.65437 ? 694 HOH   A O   1 
HETATM 2193 O O   . HOH   D 4 .   ? 0.46700   -25.57000 -34.15900 1.000 44.76716 ? 695 HOH   A O   1 
HETATM 2194 O O   . HOH   D 4 .   ? -12.42800 -8.20700  -14.75400 1.000 47.78375 ? 696 HOH   A O   1 
HETATM 2195 O O   . HOH   D 4 .   ? 19.13300  -14.11500 -5.35700  1.000 46.43081 ? 697 HOH   A O   1 
HETATM 2196 O O   . HOH   D 4 .   ? 16.12300  -15.88000 -48.59800 1.000 62.43064 ? 698 HOH   A O   1 
HETATM 2197 O O   . HOH   D 4 .   ? -12.05800 -7.78900  -24.65700 1.000 45.81833 ? 699 HOH   A O   1 
HETATM 2198 O O   . HOH   D 4 .   ? 3.353     5.675     -11.698   1.000 47.74708 ? 700 HOH   A O   1 
HETATM 2199 O O   . HOH   D 4 .   ? -10.77700 -9.65700  -29.87200 1.000 44.96433 ? 701 HOH   A O   1 
HETATM 2200 O O   . HOH   D 4 .   ? -9.93200  -10.67100 -27.67100 1.000 39.22904 ? 702 HOH   A O   1 
HETATM 2201 O O   . HOH   D 4 .   ? 5.12000   -7.37600  -28.87100 1.000 38.71875 ? 703 HOH   A O   1 
HETATM 2202 O O   . HOH   D 4 .   ? -10.05700 -2.76600  -24.70300 1.000 46.80758 ? 704 HOH   A O   1 
HETATM 2203 O O   . HOH   D 4 .   ? 2.820     7.291     -13.826   1.000 45.99809 ? 705 HOH   A O   1 
# 
