data_8YSU
# 
_entry.id   8YSU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YSU         pdb_00008ysu 10.2210/pdb8ysu/pdb 
WWPDB D_1300046315 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YSU 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chyeah6599@nchu.edu.tw 
_pdbx_contact_author.name_first         Yeh 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7740-0446 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, Y.-C.' 1 ? 
'Yang, C.-S.' 2 ? 
'Hou, M.-H.'  3 ? 
'Chen, Y.'    4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            295 
_citation.language                  ? 
_citation.page_first                139534 
_citation.page_last                 139534 
_citation.title                     
'Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.139534 
_citation.pdbx_database_id_PubMed   39761885 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, C.S.'  1 ? 
primary 'Shie, M.Y.'  2 ? 
primary 'Huang, S.W.' 3 ? 
primary 'Wang, Y.C.'  4 ? 
primary 'Hou, M.H.'   5 ? 
primary 'Chen, C.J.'  6 ? 
primary 'Chen, Y.'    7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleotidyltransferase     39217.918 1   ? ? ? ? 
2 non-polymer syn "CYTIDINE-5'-TRIPHOSPHATE" 483.156   2   ? ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'            24.305    2   ? ? ? ? 
4 water       nat water                      18.015    244 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "CYTIDINE-5'-TRIPHOSPHATE" CTP 
3 'MAGNESIUM ION'            MG  
4 water                      HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PRO n 
1 4   VAL n 
1 5   GLN n 
1 6   LYS n 
1 7   GLN n 
1 8   PHE n 
1 9   ARG n 
1 10  GLU n 
1 11  PHE n 
1 12  HIS n 
1 13  ASP n 
1 14  ARG n 
1 15  ILE n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLN n 
1 20  TYR n 
1 21  ASP n 
1 22  GLU n 
1 23  ASN n 
1 24  GLN n 
1 25  THR n 
1 26  LEU n 
1 27  ARG n 
1 28  ASP n 
1 29  GLU n 
1 30  ARG n 
1 31  ASP n 
1 32  ALA n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  ALA n 
1 37  VAL n 
1 38  ARG n 
1 39  GLU n 
1 40  GLY n 
1 41  LEU n 
1 42  LYS n 
1 43  LYS n 
1 44  VAL n 
1 45  PHE n 
1 46  ALA n 
1 47  ASP n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  ALA n 
1 52  ALA n 
1 53  PRO n 
1 54  THR n 
1 55  PHE n 
1 56  THR n 
1 57  PRO n 
1 58  PHE n 
1 59  ASN n 
1 60  GLN n 
1 61  GLY n 
1 62  SER n 
1 63  TYR n 
1 64  ALA n 
1 65  MET n 
1 66  ASN n 
1 67  THR n 
1 68  GLY n 
1 69  VAL n 
1 70  LYS n 
1 71  PRO n 
1 72  LEU n 
1 73  GLU n 
1 74  GLY n 
1 75  GLY n 
1 76  GLU n 
1 77  TYR n 
1 78  ASP n 
1 79  ILE n 
1 80  ASP n 
1 81  VAL n 
1 82  GLY n 
1 83  ILE n 
1 84  ILE n 
1 85  LEU n 
1 86  ASN n 
1 87  ILE n 
1 88  ALA n 
1 89  LYS n 
1 90  ASP n 
1 91  ASP n 
1 92  HIS n 
1 93  ASP n 
1 94  PRO n 
1 95  VAL n 
1 96  GLU n 
1 97  VAL n 
1 98  LYS n 
1 99  LYS n 
1 100 TRP n 
1 101 ILE n 
1 102 ARG n 
1 103 ASP n 
1 104 ALA n 
1 105 LEU n 
1 106 LYS n 
1 107 ASP n 
1 108 TYR n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 ALA n 
1 113 GLU n 
1 114 ILE n 
1 115 ARG n 
1 116 ARG n 
1 117 SER n 
1 118 CYS n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 PHE n 
1 123 LYS n 
1 124 PRO n 
1 125 GLY n 
1 126 TYR n 
1 127 HIS n 
1 128 VAL n 
1 129 ASP n 
1 130 LEU n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 ALA n 
1 135 ASP n 
1 136 PRO n 
1 137 GLU n 
1 138 LEU n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 LEU n 
1 144 CYS n 
1 145 ILE n 
1 146 ALA n 
1 147 LYS n 
1 148 GLY n 
1 149 LYS n 
1 150 GLU n 
1 151 ASN n 
1 152 SER n 
1 153 GLY n 
1 154 ASP n 
1 155 GLU n 
1 156 HIS n 
1 157 ARG n 
1 158 LEU n 
1 159 TRP n 
1 160 GLN n 
1 161 ILE n 
1 162 SER n 
1 163 ASP n 
1 164 PRO n 
1 165 GLN n 
1 166 GLY n 
1 167 PHE n 
1 168 GLN n 
1 169 ASP n 
1 170 ARG n 
1 171 ILE n 
1 172 ALA n 
1 173 SER n 
1 174 LYS n 
1 175 LEU n 
1 176 SER n 
1 177 GLY n 
1 178 ASP n 
1 179 ASP n 
1 180 ALA n 
1 181 ALA n 
1 182 GLN n 
1 183 PHE n 
1 184 ARG n 
1 185 ARG n 
1 186 CYS n 
1 187 ILE n 
1 188 ARG n 
1 189 TYR n 
1 190 LEU n 
1 191 LYS n 
1 192 ARG n 
1 193 TRP n 
1 194 ARG n 
1 195 ASP n 
1 196 PHE n 
1 197 ARG n 
1 198 PHE n 
1 199 SER n 
1 200 SER n 
1 201 ASP n 
1 202 GLY n 
1 203 ASN n 
1 204 ALA n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 LEU n 
1 212 THR n 
1 213 ALA n 
1 214 ALA n 
1 215 ALA n 
1 216 TYR n 
1 217 TRP n 
1 218 TRP n 
1 219 PHE n 
1 220 GLN n 
1 221 VAL n 
1 222 SER n 
1 223 LYS n 
1 224 ARG n 
1 225 THR n 
1 226 ASP n 
1 227 PRO n 
1 228 VAL n 
1 229 SER n 
1 230 GLN n 
1 231 ASN n 
1 232 VAL n 
1 233 THR n 
1 234 TYR n 
1 235 ASP n 
1 236 ASP n 
1 237 ARG n 
1 238 ASP n 
1 239 ALA n 
1 240 LEU n 
1 241 GLU n 
1 242 GLN n 
1 243 PHE n 
1 244 VAL n 
1 245 GLN n 
1 246 THR n 
1 247 MET n 
1 248 LEU n 
1 249 ASP n 
1 250 ASN n 
1 251 PHE n 
1 252 HIS n 
1 253 ASP n 
1 254 THR n 
1 255 TRP n 
1 256 ASP n 
1 257 SER n 
1 258 LYS n 
1 259 ASP n 
1 260 GLN n 
1 261 ARG n 
1 262 SER n 
1 263 TYR n 
1 264 PRO n 
1 265 ARG n 
1 266 LEU n 
1 267 THR n 
1 268 VAL n 
1 269 GLU n 
1 270 LEU n 
1 271 PRO n 
1 272 VAL n 
1 273 GLN n 
1 274 PRO n 
1 275 TYR n 
1 276 ASN n 
1 277 ASP n 
1 278 VAL n 
1 279 PHE n 
1 280 GLU n 
1 281 LYS n 
1 282 MET n 
1 283 THR n 
1 284 GLY n 
1 285 MET n 
1 286 GLN n 
1 287 MET n 
1 288 GLU n 
1 289 SER n 
1 290 PHE n 
1 291 LYS n 
1 292 SER n 
1 293 LYS n 
1 294 LEU n 
1 295 GLN n 
1 296 ALA n 
1 297 LEU n 
1 298 LEU n 
1 299 ASN n 
1 300 ALA n 
1 301 LEU n 
1 302 LYS n 
1 303 THR n 
1 304 ALA n 
1 305 LYS n 
1 306 SER n 
1 307 ARG n 
1 308 LEU n 
1 309 GLU n 
1 310 LEU n 
1 311 HIS n 
1 312 ASP n 
1 313 ALA n 
1 314 CYS n 
1 315 LYS n 
1 316 ALA n 
1 317 LEU n 
1 318 ALA n 
1 319 ASP n 
1 320 HIS n 
1 321 PHE n 
1 322 GLY n 
1 323 SER n 
1 324 GLU n 
1 325 PHE n 
1 326 PRO n 
1 327 VAL n 
1 328 PRO n 
1 329 GLU n 
1 330 LYS n 
1 331 ASP n 
1 332 LYS n 
1 333 SER n 
1 334 ALA n 
1 335 VAL n 
1 336 HIS n 
1 337 THR n 
1 338 ALA n 
1 339 PRO n 
1 340 ALA n 
1 341 ILE n 
1 342 VAL n 
1 343 GLY n 
1 344 SER n 
1 345 GLY n 
1 346 SER n 
1 347 SER n 
1 348 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   348 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 DVJ83_15700 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Deinococcus wulumuqiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     980427 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                    ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                   ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                 ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'            ? 'C4 H7 N O4'       133.103 
CTP non-polymer         . "CYTIDINE-5'-TRIPHOSPHATE" ? 'C9 H16 N3 O14 P3' 483.156 
CYS 'L-peptide linking' y CYSTEINE                   ? 'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking' y GLUTAMINE                  ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'            ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                    ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking' y HISTIDINE                  ? 'C6 H10 N3 O2 1'   156.162 
HOH non-polymer         . WATER                      ? 'H2 O'             18.015  
ILE 'L-peptide linking' y ISOLEUCINE                 ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                    ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                     ? 'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE                 ? 'C5 H11 N O2 S'    149.211 
MG  non-polymer         . 'MAGNESIUM ION'            ? 'Mg 2'             24.305  
PHE 'L-peptide linking' y PHENYLALANINE              ? 'C9 H11 N O2'      165.189 
PRO 'L-peptide linking' y PROLINE                    ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                     ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                  ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                 ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                   ? 'C9 H11 N O3'      181.189 
VAL 'L-peptide linking' y VALINE                     ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PRO 3   3   3   PRO PRO A . n 
A 1 4   VAL 4   4   4   VAL VAL A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ALA 18  18  18  ALA ALA A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ASP 28  28  28  ASP ASP A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  ARG 30  30  30  ARG ARG A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  THR 35  35  35  THR THR A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  PRO 53  53  53  PRO PRO A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  TYR 63  63  63  TYR TYR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  MET 65  65  65  MET MET A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 CYS 118 118 118 CYS CYS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 HIS 127 127 127 HIS HIS A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 GLY 141 141 141 GLY GLY A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 ASP 154 154 154 ASP ASP A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 HIS 156 156 156 HIS HIS A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 PRO 164 164 164 PRO PRO A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLN 168 168 168 GLN GLN A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 CYS 186 186 186 CYS CYS A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 VAL 221 221 221 VAL VAL A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLN 230 230 230 GLN GLN A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 TYR 234 234 234 TYR TYR A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 ARG 237 237 237 ARG ARG A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 PHE 243 243 243 PHE PHE A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 MET 247 247 247 MET MET A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 ASP 249 249 249 ASP ASP A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 HIS 252 252 252 HIS HIS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 TRP 255 255 255 TRP TRP A . n 
A 1 256 ASP 256 256 256 ASP ASP A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 PRO 264 264 264 PRO PRO A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 GLU 269 269 269 GLU GLU A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 ASP 277 277 277 ASP ASP A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 LYS 281 281 281 LYS LYS A . n 
A 1 282 MET 282 282 282 MET MET A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 SER 289 289 289 SER SER A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 GLN 295 295 295 GLN GLN A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 LEU 297 297 297 LEU LEU A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 SER 306 306 306 SER SER A . n 
A 1 307 ARG 307 307 307 ARG ARG A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 GLU 309 309 309 GLU GLU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 HIS 311 311 311 HIS HIS A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 ALA 318 318 318 ALA ALA A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 320 HIS HIS A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 GLU 324 324 324 GLU GLU A . n 
A 1 325 PHE 325 325 325 PHE PHE A . n 
A 1 326 PRO 326 326 326 PRO PRO A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 PRO 328 328 328 PRO PRO A . n 
A 1 329 GLU 329 329 329 GLU GLU A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 ASP 331 331 ?   ?   ?   A . n 
A 1 332 LYS 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 ALA 334 334 ?   ?   ?   A . n 
A 1 335 VAL 335 335 ?   ?   ?   A . n 
A 1 336 HIS 336 336 ?   ?   ?   A . n 
A 1 337 THR 337 337 ?   ?   ?   A . n 
A 1 338 ALA 338 338 ?   ?   ?   A . n 
A 1 339 PRO 339 339 ?   ?   ?   A . n 
A 1 340 ALA 340 340 ?   ?   ?   A . n 
A 1 341 ILE 341 341 ?   ?   ?   A . n 
A 1 342 VAL 342 342 ?   ?   ?   A . n 
A 1 343 GLY 343 343 ?   ?   ?   A . n 
A 1 344 SER 344 344 ?   ?   ?   A . n 
A 1 345 GLY 345 345 ?   ?   ?   A . n 
A 1 346 SER 346 346 ?   ?   ?   A . n 
A 1 347 SER 347 347 ?   ?   ?   A . n 
A 1 348 GLY 348 348 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        CTP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   CTP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CTP 1   401 401 CTP CTP A . 
C 2 CTP 1   402 402 CTP CTP A . 
D 3 MG  1   403 411 MG  MG  A . 
E 3 MG  1   404 412 MG  MG  A . 
F 4 HOH 1   501 632 HOH HOH A . 
F 4 HOH 2   502 581 HOH HOH A . 
F 4 HOH 3   503 694 HOH HOH A . 
F 4 HOH 4   504 653 HOH HOH A . 
F 4 HOH 5   505 609 HOH HOH A . 
F 4 HOH 6   506 534 HOH HOH A . 
F 4 HOH 7   507 627 HOH HOH A . 
F 4 HOH 8   508 536 HOH HOH A . 
F 4 HOH 9   509 636 HOH HOH A . 
F 4 HOH 10  510 529 HOH HOH A . 
F 4 HOH 11  511 684 HOH HOH A . 
F 4 HOH 12  512 520 HOH HOH A . 
F 4 HOH 13  513 664 HOH HOH A . 
F 4 HOH 14  514 566 HOH HOH A . 
F 4 HOH 15  515 610 HOH HOH A . 
F 4 HOH 16  516 681 HOH HOH A . 
F 4 HOH 17  517 552 HOH HOH A . 
F 4 HOH 18  518 648 HOH HOH A . 
F 4 HOH 19  519 582 HOH HOH A . 
F 4 HOH 20  520 540 HOH HOH A . 
F 4 HOH 21  521 547 HOH HOH A . 
F 4 HOH 22  522 579 HOH HOH A . 
F 4 HOH 23  523 570 HOH HOH A . 
F 4 HOH 24  524 521 HOH HOH A . 
F 4 HOH 25  525 508 HOH HOH A . 
F 4 HOH 26  526 551 HOH HOH A . 
F 4 HOH 27  527 574 HOH HOH A . 
F 4 HOH 28  528 526 HOH HOH A . 
F 4 HOH 29  529 641 HOH HOH A . 
F 4 HOH 30  530 592 HOH HOH A . 
F 4 HOH 31  531 502 HOH HOH A . 
F 4 HOH 32  532 556 HOH HOH A . 
F 4 HOH 33  533 563 HOH HOH A . 
F 4 HOH 34  534 644 HOH HOH A . 
F 4 HOH 35  535 663 HOH HOH A . 
F 4 HOH 36  536 686 HOH HOH A . 
F 4 HOH 37  537 516 HOH HOH A . 
F 4 HOH 38  538 528 HOH HOH A . 
F 4 HOH 39  539 716 HOH HOH A . 
F 4 HOH 40  540 682 HOH HOH A . 
F 4 HOH 41  541 538 HOH HOH A . 
F 4 HOH 42  542 695 HOH HOH A . 
F 4 HOH 43  543 543 HOH HOH A . 
F 4 HOH 44  544 503 HOH HOH A . 
F 4 HOH 45  545 617 HOH HOH A . 
F 4 HOH 46  546 600 HOH HOH A . 
F 4 HOH 47  547 630 HOH HOH A . 
F 4 HOH 48  548 587 HOH HOH A . 
F 4 HOH 49  549 701 HOH HOH A . 
F 4 HOH 50  550 523 HOH HOH A . 
F 4 HOH 51  551 679 HOH HOH A . 
F 4 HOH 52  552 571 HOH HOH A . 
F 4 HOH 53  553 673 HOH HOH A . 
F 4 HOH 54  554 708 HOH HOH A . 
F 4 HOH 55  555 680 HOH HOH A . 
F 4 HOH 56  556 691 HOH HOH A . 
F 4 HOH 57  557 667 HOH HOH A . 
F 4 HOH 58  558 542 HOH HOH A . 
F 4 HOH 59  559 561 HOH HOH A . 
F 4 HOH 60  560 688 HOH HOH A . 
F 4 HOH 61  561 612 HOH HOH A . 
F 4 HOH 62  562 674 HOH HOH A . 
F 4 HOH 63  563 650 HOH HOH A . 
F 4 HOH 64  564 537 HOH HOH A . 
F 4 HOH 65  565 518 HOH HOH A . 
F 4 HOH 66  566 557 HOH HOH A . 
F 4 HOH 67  567 597 HOH HOH A . 
F 4 HOH 68  568 595 HOH HOH A . 
F 4 HOH 69  569 603 HOH HOH A . 
F 4 HOH 70  570 593 HOH HOH A . 
F 4 HOH 71  571 541 HOH HOH A . 
F 4 HOH 72  572 522 HOH HOH A . 
F 4 HOH 73  573 515 HOH HOH A . 
F 4 HOH 74  574 558 HOH HOH A . 
F 4 HOH 75  575 553 HOH HOH A . 
F 4 HOH 76  576 535 HOH HOH A . 
F 4 HOH 77  577 512 HOH HOH A . 
F 4 HOH 78  578 659 HOH HOH A . 
F 4 HOH 79  579 601 HOH HOH A . 
F 4 HOH 80  580 624 HOH HOH A . 
F 4 HOH 81  581 628 HOH HOH A . 
F 4 HOH 82  582 591 HOH HOH A . 
F 4 HOH 83  583 718 HOH HOH A . 
F 4 HOH 84  584 723 HOH HOH A . 
F 4 HOH 85  585 599 HOH HOH A . 
F 4 HOH 86  586 710 HOH HOH A . 
F 4 HOH 87  587 637 HOH HOH A . 
F 4 HOH 88  588 604 HOH HOH A . 
F 4 HOH 89  589 656 HOH HOH A . 
F 4 HOH 90  590 623 HOH HOH A . 
F 4 HOH 91  591 645 HOH HOH A . 
F 4 HOH 92  592 629 HOH HOH A . 
F 4 HOH 93  593 671 HOH HOH A . 
F 4 HOH 94  594 602 HOH HOH A . 
F 4 HOH 95  595 577 HOH HOH A . 
F 4 HOH 96  596 505 HOH HOH A . 
F 4 HOH 97  597 607 HOH HOH A . 
F 4 HOH 98  598 554 HOH HOH A . 
F 4 HOH 99  599 530 HOH HOH A . 
F 4 HOH 100 600 662 HOH HOH A . 
F 4 HOH 101 601 513 HOH HOH A . 
F 4 HOH 102 602 635 HOH HOH A . 
F 4 HOH 103 603 672 HOH HOH A . 
F 4 HOH 104 604 704 HOH HOH A . 
F 4 HOH 105 605 550 HOH HOH A . 
F 4 HOH 106 606 633 HOH HOH A . 
F 4 HOH 107 607 509 HOH HOH A . 
F 4 HOH 108 608 613 HOH HOH A . 
F 4 HOH 109 609 504 HOH HOH A . 
F 4 HOH 110 610 625 HOH HOH A . 
F 4 HOH 111 611 693 HOH HOH A . 
F 4 HOH 112 612 690 HOH HOH A . 
F 4 HOH 113 613 580 HOH HOH A . 
F 4 HOH 114 614 517 HOH HOH A . 
F 4 HOH 115 615 714 HOH HOH A . 
F 4 HOH 116 616 626 HOH HOH A . 
F 4 HOH 117 617 533 HOH HOH A . 
F 4 HOH 118 618 500 HOH HOH A . 
F 4 HOH 119 619 532 HOH HOH A . 
F 4 HOH 120 620 545 HOH HOH A . 
F 4 HOH 121 621 697 HOH HOH A . 
F 4 HOH 122 622 620 HOH HOH A . 
F 4 HOH 123 623 548 HOH HOH A . 
F 4 HOH 124 624 568 HOH HOH A . 
F 4 HOH 125 625 631 HOH HOH A . 
F 4 HOH 126 626 585 HOH HOH A . 
F 4 HOH 127 627 622 HOH HOH A . 
F 4 HOH 128 628 560 HOH HOH A . 
F 4 HOH 129 629 666 HOH HOH A . 
F 4 HOH 130 630 719 HOH HOH A . 
F 4 HOH 131 631 519 HOH HOH A . 
F 4 HOH 132 632 510 HOH HOH A . 
F 4 HOH 133 633 565 HOH HOH A . 
F 4 HOH 134 634 544 HOH HOH A . 
F 4 HOH 135 635 596 HOH HOH A . 
F 4 HOH 136 636 687 HOH HOH A . 
F 4 HOH 137 637 721 HOH HOH A . 
F 4 HOH 138 638 611 HOH HOH A . 
F 4 HOH 139 639 524 HOH HOH A . 
F 4 HOH 140 640 514 HOH HOH A . 
F 4 HOH 141 641 555 HOH HOH A . 
F 4 HOH 142 642 642 HOH HOH A . 
F 4 HOH 143 643 606 HOH HOH A . 
F 4 HOH 144 644 531 HOH HOH A . 
F 4 HOH 145 645 652 HOH HOH A . 
F 4 HOH 146 646 692 HOH HOH A . 
F 4 HOH 147 647 573 HOH HOH A . 
F 4 HOH 148 648 651 HOH HOH A . 
F 4 HOH 149 649 675 HOH HOH A . 
F 4 HOH 150 650 670 HOH HOH A . 
F 4 HOH 151 651 654 HOH HOH A . 
F 4 HOH 152 652 715 HOH HOH A . 
F 4 HOH 153 653 589 HOH HOH A . 
F 4 HOH 154 654 669 HOH HOH A . 
F 4 HOH 155 655 583 HOH HOH A . 
F 4 HOH 156 656 706 HOH HOH A . 
F 4 HOH 157 657 646 HOH HOH A . 
F 4 HOH 158 658 736 HOH HOH A . 
F 4 HOH 159 659 511 HOH HOH A . 
F 4 HOH 160 660 712 HOH HOH A . 
F 4 HOH 161 661 506 HOH HOH A . 
F 4 HOH 162 662 584 HOH HOH A . 
F 4 HOH 163 663 655 HOH HOH A . 
F 4 HOH 164 664 725 HOH HOH A . 
F 4 HOH 165 665 614 HOH HOH A . 
F 4 HOH 166 666 720 HOH HOH A . 
F 4 HOH 167 667 722 HOH HOH A . 
F 4 HOH 168 668 525 HOH HOH A . 
F 4 HOH 169 669 527 HOH HOH A . 
F 4 HOH 170 670 621 HOH HOH A . 
F 4 HOH 171 671 575 HOH HOH A . 
F 4 HOH 172 672 703 HOH HOH A . 
F 4 HOH 173 673 638 HOH HOH A . 
F 4 HOH 174 674 549 HOH HOH A . 
F 4 HOH 175 675 590 HOH HOH A . 
F 4 HOH 176 676 658 HOH HOH A . 
F 4 HOH 177 677 567 HOH HOH A . 
F 4 HOH 178 678 501 HOH HOH A . 
F 4 HOH 179 679 683 HOH HOH A . 
F 4 HOH 180 680 615 HOH HOH A . 
F 4 HOH 181 681 608 HOH HOH A . 
F 4 HOH 182 682 598 HOH HOH A . 
F 4 HOH 183 683 705 HOH HOH A . 
F 4 HOH 184 684 724 HOH HOH A . 
F 4 HOH 185 685 677 HOH HOH A . 
F 4 HOH 186 686 572 HOH HOH A . 
F 4 HOH 187 687 586 HOH HOH A . 
F 4 HOH 188 688 665 HOH HOH A . 
F 4 HOH 189 689 727 HOH HOH A . 
F 4 HOH 190 690 732 HOH HOH A . 
F 4 HOH 191 691 539 HOH HOH A . 
F 4 HOH 192 692 730 HOH HOH A . 
F 4 HOH 193 693 564 HOH HOH A . 
F 4 HOH 194 694 738 HOH HOH A . 
F 4 HOH 195 695 661 HOH HOH A . 
F 4 HOH 196 696 578 HOH HOH A . 
F 4 HOH 197 697 737 HOH HOH A . 
F 4 HOH 198 698 713 HOH HOH A . 
F 4 HOH 199 699 507 HOH HOH A . 
F 4 HOH 200 700 660 HOH HOH A . 
F 4 HOH 201 701 702 HOH HOH A . 
F 4 HOH 202 702 618 HOH HOH A . 
F 4 HOH 203 703 676 HOH HOH A . 
F 4 HOH 204 704 588 HOH HOH A . 
F 4 HOH 205 705 576 HOH HOH A . 
F 4 HOH 206 706 733 HOH HOH A . 
F 4 HOH 207 707 689 HOH HOH A . 
F 4 HOH 208 708 700 HOH HOH A . 
F 4 HOH 209 709 709 HOH HOH A . 
F 4 HOH 210 710 559 HOH HOH A . 
F 4 HOH 211 711 562 HOH HOH A . 
F 4 HOH 212 712 643 HOH HOH A . 
F 4 HOH 213 713 678 HOH HOH A . 
F 4 HOH 214 714 647 HOH HOH A . 
F 4 HOH 215 715 657 HOH HOH A . 
F 4 HOH 216 716 743 HOH HOH A . 
F 4 HOH 217 717 639 HOH HOH A . 
F 4 HOH 218 718 668 HOH HOH A . 
F 4 HOH 219 719 717 HOH HOH A . 
F 4 HOH 220 720 729 HOH HOH A . 
F 4 HOH 221 721 640 HOH HOH A . 
F 4 HOH 222 722 698 HOH HOH A . 
F 4 HOH 223 723 546 HOH HOH A . 
F 4 HOH 224 724 699 HOH HOH A . 
F 4 HOH 225 725 616 HOH HOH A . 
F 4 HOH 226 726 594 HOH HOH A . 
F 4 HOH 227 727 634 HOH HOH A . 
F 4 HOH 228 728 728 HOH HOH A . 
F 4 HOH 229 729 726 HOH HOH A . 
F 4 HOH 230 730 707 HOH HOH A . 
F 4 HOH 231 731 739 HOH HOH A . 
F 4 HOH 232 732 696 HOH HOH A . 
F 4 HOH 233 733 741 HOH HOH A . 
F 4 HOH 234 734 735 HOH HOH A . 
F 4 HOH 235 735 569 HOH HOH A . 
F 4 HOH 236 736 685 HOH HOH A . 
F 4 HOH 237 737 605 HOH HOH A . 
F 4 HOH 238 738 734 HOH HOH A . 
F 4 HOH 239 739 649 HOH HOH A . 
F 4 HOH 240 740 731 HOH HOH A . 
F 4 HOH 241 741 711 HOH HOH A . 
F 4 HOH 242 742 740 HOH HOH A . 
F 4 HOH 243 743 742 HOH HOH A . 
F 4 HOH 244 744 619 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0267 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? Blu-Ice  ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   100.415 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YSU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.363 
_cell.length_a_esd                 ? 
_cell.length_b                     111.506 
_cell.length_b_esd                 ? 
_cell.length_c                     46.981 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YSU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YSU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.32 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.05 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M BIS-TRIS propane pH 9.0, 
30% w/v Polyethylene glycol 6,000.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-05-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97624 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 07A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97624 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 07A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YSU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.94 
_reflns.d_resolution_low                               30.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25742 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.2 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.424 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.94 
_reflns_shell.d_res_low                                     2.01 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2511 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.705 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.010 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.269 
_refine.aniso_B[2][2]                            -0.032 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            -0.053 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               26.792 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.935 
_refine.correlation_coeff_Fo_to_Fc_free          0.919 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YSU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.944 
_refine.ls_d_res_low                             23.881 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25173 
_refine.ls_number_reflns_R_free                  1245 
_refine.ls_number_reflns_R_work                  23867 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.635 
_refine.ls_percent_reflns_R_free                 5.188 
_refine.ls_R_factor_all                          0.204 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2389 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2021 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.201 
_refine.pdbx_overall_ESU_R_Free                  0.169 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             4.742 
_refine.overall_SU_ML                            0.131 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2647 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         60 
_refine_hist.number_atoms_solvent             244 
_refine_hist.number_atoms_total               2951 
_refine_hist.d_res_high                       1.944 
_refine_hist.d_res_low                        23.881 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  0.013  2768 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2534 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.444  1.654  3754 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.314  1.593  5837 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.658  5.000  329  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 33.034 22.134 164  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.941 15.000 464  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 13.682 15.000 22   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.065  0.200  348  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.008  0.020  3131 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  668  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.220  0.200  605  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.192  0.200  2387 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.168  0.200  1341 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.079  0.200  1264 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.175  0.200  185  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.155  0.200  12   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.257  0.200  23   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.246  0.200  10   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.207  2.604  1319 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.193  2.603  1318 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 3.412  3.893  1647 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.413  3.895  1648 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.024  3.058  1449 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.887  2.944  1438 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.909  4.517  2107 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.908  4.524  2108 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 8.356  31.154 3210 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.335  31.037 3167 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.944 1.994  . . 80  1444 78.3145 . . . . 0.302 . . . . . . . . . . . 0.330 
'X-RAY DIFFRACTION' 1.994 2.049  . . 85  1603 89.1236 . . . . 0.262 . . . . . . . . . . . 0.294 
'X-RAY DIFFRACTION' 2.049 2.108  . . 91  1592 93.5520 . . . . 0.238 . . . . . . . . . . . 0.287 
'X-RAY DIFFRACTION' 2.108 2.172  . . 105 1634 97.4776 . . . . 0.235 . . . . . . . . . . . 0.314 
'X-RAY DIFFRACTION' 2.172 2.243  . . 92  1615 97.7663 . . . . 0.218 . . . . . . . . . . . 0.257 
'X-RAY DIFFRACTION' 2.243 2.321  . . 89  1525 97.8182 . . . . 0.211 . . . . . . . . . . . 0.266 
'X-RAY DIFFRACTION' 2.321 2.409  . . 80  1502 98.4443 . . . . 0.204 . . . . . . . . . . . 0.238 
'X-RAY DIFFRACTION' 2.409 2.506  . . 74  1423 96.2701 . . . . 0.197 . . . . . . . . . . . 0.293 
'X-RAY DIFFRACTION' 2.506 2.617  . . 81  1360 96.5818 . . . . 0.192 . . . . . . . . . . . 0.248 
'X-RAY DIFFRACTION' 2.617 2.743  . . 87  1328 98.4006 . . . . 0.171 . . . . . . . . . . . 0.216 
'X-RAY DIFFRACTION' 2.743 2.891  . . 63  1268 99.0327 . . . . 0.185 . . . . . . . . . . . 0.219 
'X-RAY DIFFRACTION' 2.891 3.064  . . 62  1207 99.2181 . . . . 0.206 . . . . . . . . . . . 0.223 
'X-RAY DIFFRACTION' 3.064 3.273  . . 52  1156 99.0976 . . . . 0.212 . . . . . . . . . . . 0.249 
'X-RAY DIFFRACTION' 3.273 3.532  . . 59  1077 99.2140 . . . . 0.208 . . . . . . . . . . . 0.215 
'X-RAY DIFFRACTION' 3.532 3.864  . . 43  975  98.7391 . . . . 0.184 . . . . . . . . . . . 0.226 
'X-RAY DIFFRACTION' 3.864 4.311  . . 48  872  98.3957 . . . . 0.169 . . . . . . . . . . . 0.215 
'X-RAY DIFFRACTION' 4.311 4.961  . . 35  780  97.3716 . . . . 0.181 . . . . . . . . . . . 0.223 
'X-RAY DIFFRACTION' 4.961 6.034  . . 35  670  99.1561 . . . . 0.224 . . . . . . . . . . . 0.200 
'X-RAY DIFFRACTION' 6.034 8.366  . . 29  521  99.2780 . . . . 0.194 . . . . . . . . . . . 0.217 
'X-RAY DIFFRACTION' 8.366 23.881 . . 16  313  96.4809 . . . . 0.166 . . . . . . . . . . . 0.161 
# 
_struct.entry_id                     8YSU 
_struct.title                        'Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with CTP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YSU 
_struct_keywords.text            'CD-NTase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A345ILN6_9DEIO 
_struct_ref.pdbx_db_accession          A0A345ILN6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YSU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 348 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A345ILN6 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  348 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       348 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1860  ? 
1 MORE         -31   ? 
1 'SSA (A^2)'  15620 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 2   ? LYS A 16  ? ALA A 2   LYS A 16  1 ? 15 
HELX_P HELX_P2  AA2 GLN A 19  ? GLU A 22  ? GLN A 19  GLU A 22  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 23  ? ARG A 48  ? ASN A 23  ARG A 48  1 ? 26 
HELX_P HELX_P4  AA4 GLY A 61  ? ASN A 66  ? GLY A 61  ASN A 66  1 ? 6  
HELX_P HELX_P5  AA5 ALA A 88  ? HIS A 92  ? ALA A 88  HIS A 92  5 ? 5  
HELX_P HELX_P6  AA6 ASP A 93  ? LEU A 105 ? ASP A 93  LEU A 105 1 ? 13 
HELX_P HELX_P7  AA7 ASP A 135 ? SER A 139 ? ASP A 135 SER A 139 5 ? 5  
HELX_P HELX_P8  AA8 GLY A 153 ? ARG A 157 ? GLY A 153 ARG A 157 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 163 ? LYS A 174 ? ASP A 163 LYS A 174 1 ? 12 
HELX_P HELX_P10 AB1 SER A 176 ? PHE A 198 ? SER A 176 PHE A 198 1 ? 23 
HELX_P HELX_P11 AB2 LEU A 207 ? PHE A 219 ? LEU A 207 PHE A 219 1 ? 13 
HELX_P HELX_P12 AB3 ASP A 235 ? PHE A 251 ? ASP A 235 PHE A 251 1 ? 17 
HELX_P HELX_P13 AB4 THR A 283 ? ARG A 307 ? THR A 283 ARG A 307 1 ? 25 
HELX_P HELX_P14 AB5 GLU A 309 ? GLY A 322 ? GLU A 309 GLY A 322 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A ASP 78  OD2   ? ? ? 1_555 D MG  . MG ? ? A ASP 78  A MG  403 1_555 ? ? ? ? ? ? ? 2.143 ? ? 
metalc2  metalc ? ? A ASP 78  OD1   ? ? ? 1_555 E MG  . MG ? ? A ASP 78  A MG  404 1_555 ? ? ? ? ? ? ? 2.324 ? ? 
metalc3  metalc ? ? A ASP 78  OD2   ? ? ? 1_555 E MG  . MG ? ? A ASP 78  A MG  404 1_555 ? ? ? ? ? ? ? 2.556 ? ? 
metalc4  metalc ? ? A ASP 80  OD1   ? ? ? 1_555 D MG  . MG ? ? A ASP 80  A MG  403 1_555 ? ? ? ? ? ? ? 2.164 ? ? 
metalc5  metalc ? ? A ASP 80  OD2   ? ? ? 1_555 E MG  . MG ? ? A ASP 80  A MG  404 1_555 ? ? ? ? ? ? ? 2.212 ? ? 
metalc6  metalc ? ? A ASP 129 OD2   ? ? ? 1_555 E MG  . MG ? ? A ASP 129 A MG  404 1_555 ? ? ? ? ? ? ? 2.425 ? ? 
metalc7  metalc ? ? B CTP .   O2A   ? ? ? 1_555 D MG  . MG ? ? A CTP 401 A MG  403 1_555 ? ? ? ? ? ? ? 2.245 ? ? 
metalc8  metalc ? ? B CTP .   O2B   ? ? ? 1_555 D MG  . MG ? ? A CTP 401 A MG  403 1_555 ? ? ? ? ? ? ? 1.995 ? ? 
metalc9  metalc ? ? B CTP .   O2G   ? ? ? 1_555 D MG  . MG ? ? A CTP 401 A MG  403 1_555 ? ? ? ? ? ? ? 2.156 ? ? 
metalc10 metalc ? ? B CTP .   O2A   ? ? ? 1_555 E MG  . MG ? ? A CTP 401 A MG  404 1_555 ? ? ? ? ? ? ? 2.509 ? ? 
metalc11 metalc ? ? C CTP .   "O2'" ? ? ? 1_555 E MG  . MG ? ? A CTP 402 A MG  404 1_555 ? ? ? ? ? ? ? 2.683 ? ? 
metalc12 metalc ? ? C CTP .   "O3'" ? ? ? 1_555 E MG  . MG ? ? A CTP 402 A MG  404 1_555 ? ? ? ? ? ? ? 2.107 ? ? 
metalc13 metalc ? ? D MG  .   MG    ? ? ? 1_555 F HOH . O  ? ? A MG  403 A HOH 516 1_555 ? ? ? ? ? ? ? 2.230 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 OD1   ? A ASP 80  ? A ASP 80  ? 1_555 90.2  ? 
2  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2A   ? B CTP .   ? A CTP 401 ? 1_555 78.9  ? 
3  OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2A   ? B CTP .   ? A CTP 401 ? 1_555 77.9  ? 
4  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2B   ? B CTP .   ? A CTP 401 ? 1_555 172.7 ? 
5  OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2B   ? B CTP .   ? A CTP 401 ? 1_555 94.6  ? 
6  O2A   ? B CTP .   ? A CTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2B   ? B CTP .   ? A CTP 401 ? 1_555 96.6  ? 
7  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2G   ? B CTP .   ? A CTP 401 ? 1_555 81.8  ? 
8  OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2G   ? B CTP .   ? A CTP 401 ? 1_555 171.7 ? 
9  O2A   ? B CTP .   ? A CTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2G   ? B CTP .   ? A CTP 401 ? 1_555 98.7  ? 
10 O2B   ? B CTP .   ? A CTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2G   ? B CTP .   ? A CTP 401 ? 1_555 93.3  ? 
11 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 89.5  ? 
12 OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 79.1  ? 
13 O2A   ? B CTP .   ? A CTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 154.2 ? 
14 O2B   ? B CTP .   ? A CTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 96.8  ? 
15 O2G   ? B CTP .   ? A CTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 102.4 ? 
16 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 52.6  ? 
17 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 93.9  ? 
18 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 87.4  ? 
19 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 76.4  ? 
20 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 129.0 ? 
21 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 96.9  ? 
22 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O2A   ? B CTP .   ? A CTP 401 ? 1_555 119.2 ? 
23 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O2A   ? B CTP .   ? A CTP 401 ? 1_555 66.9  ? 
24 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O2A   ? B CTP .   ? A CTP 401 ? 1_555 88.3  ? 
25 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O2A   ? B CTP .   ? A CTP 401 ? 1_555 163.3 ? 
26 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C CTP .   ? A CTP 402 ? 1_555 146.6 ? 
27 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C CTP .   ? A CTP 402 ? 1_555 148.5 ? 
28 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C CTP .   ? A CTP 402 ? 1_555 69.9  ? 
29 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C CTP .   ? A CTP 402 ? 1_555 76.8  ? 
30 O2A   ? B CTP .   ? A CTP 401 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C CTP .   ? A CTP 402 ? 1_555 90.2  ? 
31 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C CTP .   ? A CTP 402 ? 1_555 130.8 ? 
32 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C CTP .   ? A CTP 402 ? 1_555 131.6 ? 
33 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C CTP .   ? A CTP 402 ? 1_555 131.7 ? 
34 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C CTP .   ? A CTP 402 ? 1_555 80.0  ? 
35 O2A   ? B CTP .   ? A CTP 401 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C CTP .   ? A CTP 402 ? 1_555 84.6  ? 
36 "O2'" ? C CTP .   ? A CTP 402 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C CTP .   ? A CTP 402 ? 1_555 62.4  ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           273 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            273 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    274 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     274 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       2.78 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? ASN A 59  ? PHE A 55  ASN A 59  
AA1 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA1 3 TYR A 126 ? TYR A 133 ? TYR A 126 TYR A 133 
AA1 4 VAL A 119 ? LYS A 123 ? VAL A 119 LYS A 123 
AA1 5 ALA A 112 ? ILE A 114 ? ALA A 112 ILE A 114 
AA2 1 CYS A 144 ? LYS A 147 ? CYS A 144 LYS A 147 
AA2 2 LEU A 158 ? ILE A 161 ? LEU A 158 ILE A 161 
AA3 1 LYS A 223 ? THR A 225 ? LYS A 223 THR A 225 
AA3 2 VAL A 232 ? TYR A 234 ? VAL A 232 TYR A 234 
AA4 1 HIS A 252 ? ASP A 256 ? HIS A 252 ASP A 256 
AA4 2 ARG A 261 ? ARG A 265 ? ARG A 261 ARG A 265 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 58  ? N PHE A 58  O GLY A 82  ? O GLY A 82  
AA1 2 3 N ILE A 83  ? N ILE A 83  O TYR A 133 ? O TYR A 133 
AA1 3 4 O LEU A 130 ? O LEU A 130 N VAL A 119 ? N VAL A 119 
AA1 4 5 O THR A 120 ? O THR A 120 N GLU A 113 ? N GLU A 113 
AA2 1 2 N LYS A 147 ? N LYS A 147 O LEU A 158 ? O LEU A 158 
AA3 1 2 N ARG A 224 ? N ARG A 224 O THR A 233 ? O THR A 233 
AA4 1 2 N ASP A 256 ? N ASP A 256 O ARG A 261 ? O ARG A 261 
# 
_pdbx_entry_details.entry_id                   8YSU 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 163 ? ? -149.49 57.16 
2 1 GLN A 230 ? ? 58.50   19.25 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ASP 331 ? A ASP 331 
2  1 Y 1 A LYS 332 ? A LYS 332 
3  1 Y 1 A SER 333 ? A SER 333 
4  1 Y 1 A ALA 334 ? A ALA 334 
5  1 Y 1 A VAL 335 ? A VAL 335 
6  1 Y 1 A HIS 336 ? A HIS 336 
7  1 Y 1 A THR 337 ? A THR 337 
8  1 Y 1 A ALA 338 ? A ALA 338 
9  1 Y 1 A PRO 339 ? A PRO 339 
10 1 Y 1 A ALA 340 ? A ALA 340 
11 1 Y 1 A ILE 341 ? A ILE 341 
12 1 Y 1 A VAL 342 ? A VAL 342 
13 1 Y 1 A GLY 343 ? A GLY 343 
14 1 Y 1 A SER 344 ? A SER 344 
15 1 Y 1 A GLY 345 ? A GLY 345 
16 1 Y 1 A SER 346 ? A SER 346 
17 1 Y 1 A SER 347 ? A SER 347 
18 1 Y 1 A GLY 348 ? A GLY 348 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CTP N1     N  N N 74  
CTP C2     C  N N 75  
CTP N3     N  N N 76  
CTP C4     C  N N 77  
CTP C5     C  N N 78  
CTP C6     C  N N 79  
CTP O2     O  N N 80  
CTP N4     N  N N 81  
CTP "C1'"  C  N R 82  
CTP "C2'"  C  N R 83  
CTP "O2'"  O  N N 84  
CTP "C3'"  C  N S 85  
CTP "C4'"  C  N R 86  
CTP "O4'"  O  N N 87  
CTP "O3'"  O  N N 88  
CTP "C5'"  C  N N 89  
CTP "O5'"  O  N N 90  
CTP PA     P  N S 91  
CTP O1A    O  N N 92  
CTP O2A    O  N N 93  
CTP O3A    O  N N 94  
CTP PB     P  N R 95  
CTP O1B    O  N N 96  
CTP O2B    O  N N 97  
CTP O3B    O  N N 98  
CTP PG     P  N N 99  
CTP O1G    O  N N 100 
CTP O2G    O  N N 101 
CTP O3G    O  N N 102 
CTP H5     H  N N 103 
CTP H6     H  N N 104 
CTP HN41   H  N N 105 
CTP HN42   H  N N 106 
CTP "H1'"  H  N N 107 
CTP "H2'"  H  N N 108 
CTP "HO2'" H  N N 109 
CTP "H3'"  H  N N 110 
CTP "H4'"  H  N N 111 
CTP "HO3'" H  N N 112 
CTP "H5'1" H  N N 113 
CTP "H5'2" H  N N 114 
CTP HOA2   H  N N 115 
CTP HOB2   H  N N 116 
CTP HOG2   H  N N 117 
CTP HOG3   H  N N 118 
CYS N      N  N N 119 
CYS CA     C  N R 120 
CYS C      C  N N 121 
CYS O      O  N N 122 
CYS CB     C  N N 123 
CYS SG     S  N N 124 
CYS OXT    O  N N 125 
CYS H      H  N N 126 
CYS H2     H  N N 127 
CYS HA     H  N N 128 
CYS HB2    H  N N 129 
CYS HB3    H  N N 130 
CYS HG     H  N N 131 
CYS HXT    H  N N 132 
GLN N      N  N N 133 
GLN CA     C  N S 134 
GLN C      C  N N 135 
GLN O      O  N N 136 
GLN CB     C  N N 137 
GLN CG     C  N N 138 
GLN CD     C  N N 139 
GLN OE1    O  N N 140 
GLN NE2    N  N N 141 
GLN OXT    O  N N 142 
GLN H      H  N N 143 
GLN H2     H  N N 144 
GLN HA     H  N N 145 
GLN HB2    H  N N 146 
GLN HB3    H  N N 147 
GLN HG2    H  N N 148 
GLN HG3    H  N N 149 
GLN HE21   H  N N 150 
GLN HE22   H  N N 151 
GLN HXT    H  N N 152 
GLU N      N  N N 153 
GLU CA     C  N S 154 
GLU C      C  N N 155 
GLU O      O  N N 156 
GLU CB     C  N N 157 
GLU CG     C  N N 158 
GLU CD     C  N N 159 
GLU OE1    O  N N 160 
GLU OE2    O  N N 161 
GLU OXT    O  N N 162 
GLU H      H  N N 163 
GLU H2     H  N N 164 
GLU HA     H  N N 165 
GLU HB2    H  N N 166 
GLU HB3    H  N N 167 
GLU HG2    H  N N 168 
GLU HG3    H  N N 169 
GLU HE2    H  N N 170 
GLU HXT    H  N N 171 
GLY N      N  N N 172 
GLY CA     C  N N 173 
GLY C      C  N N 174 
GLY O      O  N N 175 
GLY OXT    O  N N 176 
GLY H      H  N N 177 
GLY H2     H  N N 178 
GLY HA2    H  N N 179 
GLY HA3    H  N N 180 
GLY HXT    H  N N 181 
HIS N      N  N N 182 
HIS CA     C  N S 183 
HIS C      C  N N 184 
HIS O      O  N N 185 
HIS CB     C  N N 186 
HIS CG     C  Y N 187 
HIS ND1    N  Y N 188 
HIS CD2    C  Y N 189 
HIS CE1    C  Y N 190 
HIS NE2    N  Y N 191 
HIS OXT    O  N N 192 
HIS H      H  N N 193 
HIS H2     H  N N 194 
HIS HA     H  N N 195 
HIS HB2    H  N N 196 
HIS HB3    H  N N 197 
HIS HD1    H  N N 198 
HIS HD2    H  N N 199 
HIS HE1    H  N N 200 
HIS HE2    H  N N 201 
HIS HXT    H  N N 202 
HOH O      O  N N 203 
HOH H1     H  N N 204 
HOH H2     H  N N 205 
ILE N      N  N N 206 
ILE CA     C  N S 207 
ILE C      C  N N 208 
ILE O      O  N N 209 
ILE CB     C  N S 210 
ILE CG1    C  N N 211 
ILE CG2    C  N N 212 
ILE CD1    C  N N 213 
ILE OXT    O  N N 214 
ILE H      H  N N 215 
ILE H2     H  N N 216 
ILE HA     H  N N 217 
ILE HB     H  N N 218 
ILE HG12   H  N N 219 
ILE HG13   H  N N 220 
ILE HG21   H  N N 221 
ILE HG22   H  N N 222 
ILE HG23   H  N N 223 
ILE HD11   H  N N 224 
ILE HD12   H  N N 225 
ILE HD13   H  N N 226 
ILE HXT    H  N N 227 
LEU N      N  N N 228 
LEU CA     C  N S 229 
LEU C      C  N N 230 
LEU O      O  N N 231 
LEU CB     C  N N 232 
LEU CG     C  N N 233 
LEU CD1    C  N N 234 
LEU CD2    C  N N 235 
LEU OXT    O  N N 236 
LEU H      H  N N 237 
LEU H2     H  N N 238 
LEU HA     H  N N 239 
LEU HB2    H  N N 240 
LEU HB3    H  N N 241 
LEU HG     H  N N 242 
LEU HD11   H  N N 243 
LEU HD12   H  N N 244 
LEU HD13   H  N N 245 
LEU HD21   H  N N 246 
LEU HD22   H  N N 247 
LEU HD23   H  N N 248 
LEU HXT    H  N N 249 
LYS N      N  N N 250 
LYS CA     C  N S 251 
LYS C      C  N N 252 
LYS O      O  N N 253 
LYS CB     C  N N 254 
LYS CG     C  N N 255 
LYS CD     C  N N 256 
LYS CE     C  N N 257 
LYS NZ     N  N N 258 
LYS OXT    O  N N 259 
LYS H      H  N N 260 
LYS H2     H  N N 261 
LYS HA     H  N N 262 
LYS HB2    H  N N 263 
LYS HB3    H  N N 264 
LYS HG2    H  N N 265 
LYS HG3    H  N N 266 
LYS HD2    H  N N 267 
LYS HD3    H  N N 268 
LYS HE2    H  N N 269 
LYS HE3    H  N N 270 
LYS HZ1    H  N N 271 
LYS HZ2    H  N N 272 
LYS HZ3    H  N N 273 
LYS HXT    H  N N 274 
MET N      N  N N 275 
MET CA     C  N S 276 
MET C      C  N N 277 
MET O      O  N N 278 
MET CB     C  N N 279 
MET CG     C  N N 280 
MET SD     S  N N 281 
MET CE     C  N N 282 
MET OXT    O  N N 283 
MET H      H  N N 284 
MET H2     H  N N 285 
MET HA     H  N N 286 
MET HB2    H  N N 287 
MET HB3    H  N N 288 
MET HG2    H  N N 289 
MET HG3    H  N N 290 
MET HE1    H  N N 291 
MET HE2    H  N N 292 
MET HE3    H  N N 293 
MET HXT    H  N N 294 
MG  MG     MG N N 295 
PHE N      N  N N 296 
PHE CA     C  N S 297 
PHE C      C  N N 298 
PHE O      O  N N 299 
PHE CB     C  N N 300 
PHE CG     C  Y N 301 
PHE CD1    C  Y N 302 
PHE CD2    C  Y N 303 
PHE CE1    C  Y N 304 
PHE CE2    C  Y N 305 
PHE CZ     C  Y N 306 
PHE OXT    O  N N 307 
PHE H      H  N N 308 
PHE H2     H  N N 309 
PHE HA     H  N N 310 
PHE HB2    H  N N 311 
PHE HB3    H  N N 312 
PHE HD1    H  N N 313 
PHE HD2    H  N N 314 
PHE HE1    H  N N 315 
PHE HE2    H  N N 316 
PHE HZ     H  N N 317 
PHE HXT    H  N N 318 
PRO N      N  N N 319 
PRO CA     C  N S 320 
PRO C      C  N N 321 
PRO O      O  N N 322 
PRO CB     C  N N 323 
PRO CG     C  N N 324 
PRO CD     C  N N 325 
PRO OXT    O  N N 326 
PRO H      H  N N 327 
PRO HA     H  N N 328 
PRO HB2    H  N N 329 
PRO HB3    H  N N 330 
PRO HG2    H  N N 331 
PRO HG3    H  N N 332 
PRO HD2    H  N N 333 
PRO HD3    H  N N 334 
PRO HXT    H  N N 335 
SER N      N  N N 336 
SER CA     C  N S 337 
SER C      C  N N 338 
SER O      O  N N 339 
SER CB     C  N N 340 
SER OG     O  N N 341 
SER OXT    O  N N 342 
SER H      H  N N 343 
SER H2     H  N N 344 
SER HA     H  N N 345 
SER HB2    H  N N 346 
SER HB3    H  N N 347 
SER HG     H  N N 348 
SER HXT    H  N N 349 
THR N      N  N N 350 
THR CA     C  N S 351 
THR C      C  N N 352 
THR O      O  N N 353 
THR CB     C  N R 354 
THR OG1    O  N N 355 
THR CG2    C  N N 356 
THR OXT    O  N N 357 
THR H      H  N N 358 
THR H2     H  N N 359 
THR HA     H  N N 360 
THR HB     H  N N 361 
THR HG1    H  N N 362 
THR HG21   H  N N 363 
THR HG22   H  N N 364 
THR HG23   H  N N 365 
THR HXT    H  N N 366 
TRP N      N  N N 367 
TRP CA     C  N S 368 
TRP C      C  N N 369 
TRP O      O  N N 370 
TRP CB     C  N N 371 
TRP CG     C  Y N 372 
TRP CD1    C  Y N 373 
TRP CD2    C  Y N 374 
TRP NE1    N  Y N 375 
TRP CE2    C  Y N 376 
TRP CE3    C  Y N 377 
TRP CZ2    C  Y N 378 
TRP CZ3    C  Y N 379 
TRP CH2    C  Y N 380 
TRP OXT    O  N N 381 
TRP H      H  N N 382 
TRP H2     H  N N 383 
TRP HA     H  N N 384 
TRP HB2    H  N N 385 
TRP HB3    H  N N 386 
TRP HD1    H  N N 387 
TRP HE1    H  N N 388 
TRP HE3    H  N N 389 
TRP HZ2    H  N N 390 
TRP HZ3    H  N N 391 
TRP HH2    H  N N 392 
TRP HXT    H  N N 393 
TYR N      N  N N 394 
TYR CA     C  N S 395 
TYR C      C  N N 396 
TYR O      O  N N 397 
TYR CB     C  N N 398 
TYR CG     C  Y N 399 
TYR CD1    C  Y N 400 
TYR CD2    C  Y N 401 
TYR CE1    C  Y N 402 
TYR CE2    C  Y N 403 
TYR CZ     C  Y N 404 
TYR OH     O  N N 405 
TYR OXT    O  N N 406 
TYR H      H  N N 407 
TYR H2     H  N N 408 
TYR HA     H  N N 409 
TYR HB2    H  N N 410 
TYR HB3    H  N N 411 
TYR HD1    H  N N 412 
TYR HD2    H  N N 413 
TYR HE1    H  N N 414 
TYR HE2    H  N N 415 
TYR HH     H  N N 416 
TYR HXT    H  N N 417 
VAL N      N  N N 418 
VAL CA     C  N S 419 
VAL C      C  N N 420 
VAL O      O  N N 421 
VAL CB     C  N N 422 
VAL CG1    C  N N 423 
VAL CG2    C  N N 424 
VAL OXT    O  N N 425 
VAL H      H  N N 426 
VAL H2     H  N N 427 
VAL HA     H  N N 428 
VAL HB     H  N N 429 
VAL HG11   H  N N 430 
VAL HG12   H  N N 431 
VAL HG13   H  N N 432 
VAL HG21   H  N N 433 
VAL HG22   H  N N 434 
VAL HG23   H  N N 435 
VAL HXT    H  N N 436 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CTP N1    C2     sing N N 70  
CTP N1    C6     sing N N 71  
CTP N1    "C1'"  sing N N 72  
CTP C2    N3     sing N N 73  
CTP C2    O2     doub N N 74  
CTP N3    C4     doub N N 75  
CTP C4    C5     sing N N 76  
CTP C4    N4     sing N N 77  
CTP C5    C6     doub N N 78  
CTP C5    H5     sing N N 79  
CTP C6    H6     sing N N 80  
CTP N4    HN41   sing N N 81  
CTP N4    HN42   sing N N 82  
CTP "C1'" "C2'"  sing N N 83  
CTP "C1'" "O4'"  sing N N 84  
CTP "C1'" "H1'"  sing N N 85  
CTP "C2'" "O2'"  sing N N 86  
CTP "C2'" "C3'"  sing N N 87  
CTP "C2'" "H2'"  sing N N 88  
CTP "O2'" "HO2'" sing N N 89  
CTP "C3'" "C4'"  sing N N 90  
CTP "C3'" "O3'"  sing N N 91  
CTP "C3'" "H3'"  sing N N 92  
CTP "C4'" "O4'"  sing N N 93  
CTP "C4'" "C5'"  sing N N 94  
CTP "C4'" "H4'"  sing N N 95  
CTP "O3'" "HO3'" sing N N 96  
CTP "C5'" "O5'"  sing N N 97  
CTP "C5'" "H5'1" sing N N 98  
CTP "C5'" "H5'2" sing N N 99  
CTP "O5'" PA     sing N N 100 
CTP PA    O1A    doub N N 101 
CTP PA    O2A    sing N N 102 
CTP PA    O3A    sing N N 103 
CTP O2A   HOA2   sing N N 104 
CTP O3A   PB     sing N N 105 
CTP PB    O1B    doub N N 106 
CTP PB    O2B    sing N N 107 
CTP PB    O3B    sing N N 108 
CTP O2B   HOB2   sing N N 109 
CTP O3B   PG     sing N N 110 
CTP PG    O1G    doub N N 111 
CTP PG    O2G    sing N N 112 
CTP PG    O3G    sing N N 113 
CTP O2G   HOG2   sing N N 114 
CTP O3G   HOG3   sing N N 115 
CYS N     CA     sing N N 116 
CYS N     H      sing N N 117 
CYS N     H2     sing N N 118 
CYS CA    C      sing N N 119 
CYS CA    CB     sing N N 120 
CYS CA    HA     sing N N 121 
CYS C     O      doub N N 122 
CYS C     OXT    sing N N 123 
CYS CB    SG     sing N N 124 
CYS CB    HB2    sing N N 125 
CYS CB    HB3    sing N N 126 
CYS SG    HG     sing N N 127 
CYS OXT   HXT    sing N N 128 
GLN N     CA     sing N N 129 
GLN N     H      sing N N 130 
GLN N     H2     sing N N 131 
GLN CA    C      sing N N 132 
GLN CA    CB     sing N N 133 
GLN CA    HA     sing N N 134 
GLN C     O      doub N N 135 
GLN C     OXT    sing N N 136 
GLN CB    CG     sing N N 137 
GLN CB    HB2    sing N N 138 
GLN CB    HB3    sing N N 139 
GLN CG    CD     sing N N 140 
GLN CG    HG2    sing N N 141 
GLN CG    HG3    sing N N 142 
GLN CD    OE1    doub N N 143 
GLN CD    NE2    sing N N 144 
GLN NE2   HE21   sing N N 145 
GLN NE2   HE22   sing N N 146 
GLN OXT   HXT    sing N N 147 
GLU N     CA     sing N N 148 
GLU N     H      sing N N 149 
GLU N     H2     sing N N 150 
GLU CA    C      sing N N 151 
GLU CA    CB     sing N N 152 
GLU CA    HA     sing N N 153 
GLU C     O      doub N N 154 
GLU C     OXT    sing N N 155 
GLU CB    CG     sing N N 156 
GLU CB    HB2    sing N N 157 
GLU CB    HB3    sing N N 158 
GLU CG    CD     sing N N 159 
GLU CG    HG2    sing N N 160 
GLU CG    HG3    sing N N 161 
GLU CD    OE1    doub N N 162 
GLU CD    OE2    sing N N 163 
GLU OE2   HE2    sing N N 164 
GLU OXT   HXT    sing N N 165 
GLY N     CA     sing N N 166 
GLY N     H      sing N N 167 
GLY N     H2     sing N N 168 
GLY CA    C      sing N N 169 
GLY CA    HA2    sing N N 170 
GLY CA    HA3    sing N N 171 
GLY C     O      doub N N 172 
GLY C     OXT    sing N N 173 
GLY OXT   HXT    sing N N 174 
HIS N     CA     sing N N 175 
HIS N     H      sing N N 176 
HIS N     H2     sing N N 177 
HIS CA    C      sing N N 178 
HIS CA    CB     sing N N 179 
HIS CA    HA     sing N N 180 
HIS C     O      doub N N 181 
HIS C     OXT    sing N N 182 
HIS CB    CG     sing N N 183 
HIS CB    HB2    sing N N 184 
HIS CB    HB3    sing N N 185 
HIS CG    ND1    sing Y N 186 
HIS CG    CD2    doub Y N 187 
HIS ND1   CE1    doub Y N 188 
HIS ND1   HD1    sing N N 189 
HIS CD2   NE2    sing Y N 190 
HIS CD2   HD2    sing N N 191 
HIS CE1   NE2    sing Y N 192 
HIS CE1   HE1    sing N N 193 
HIS NE2   HE2    sing N N 194 
HIS OXT   HXT    sing N N 195 
HOH O     H1     sing N N 196 
HOH O     H2     sing N N 197 
ILE N     CA     sing N N 198 
ILE N     H      sing N N 199 
ILE N     H2     sing N N 200 
ILE CA    C      sing N N 201 
ILE CA    CB     sing N N 202 
ILE CA    HA     sing N N 203 
ILE C     O      doub N N 204 
ILE C     OXT    sing N N 205 
ILE CB    CG1    sing N N 206 
ILE CB    CG2    sing N N 207 
ILE CB    HB     sing N N 208 
ILE CG1   CD1    sing N N 209 
ILE CG1   HG12   sing N N 210 
ILE CG1   HG13   sing N N 211 
ILE CG2   HG21   sing N N 212 
ILE CG2   HG22   sing N N 213 
ILE CG2   HG23   sing N N 214 
ILE CD1   HD11   sing N N 215 
ILE CD1   HD12   sing N N 216 
ILE CD1   HD13   sing N N 217 
ILE OXT   HXT    sing N N 218 
LEU N     CA     sing N N 219 
LEU N     H      sing N N 220 
LEU N     H2     sing N N 221 
LEU CA    C      sing N N 222 
LEU CA    CB     sing N N 223 
LEU CA    HA     sing N N 224 
LEU C     O      doub N N 225 
LEU C     OXT    sing N N 226 
LEU CB    CG     sing N N 227 
LEU CB    HB2    sing N N 228 
LEU CB    HB3    sing N N 229 
LEU CG    CD1    sing N N 230 
LEU CG    CD2    sing N N 231 
LEU CG    HG     sing N N 232 
LEU CD1   HD11   sing N N 233 
LEU CD1   HD12   sing N N 234 
LEU CD1   HD13   sing N N 235 
LEU CD2   HD21   sing N N 236 
LEU CD2   HD22   sing N N 237 
LEU CD2   HD23   sing N N 238 
LEU OXT   HXT    sing N N 239 
LYS N     CA     sing N N 240 
LYS N     H      sing N N 241 
LYS N     H2     sing N N 242 
LYS CA    C      sing N N 243 
LYS CA    CB     sing N N 244 
LYS CA    HA     sing N N 245 
LYS C     O      doub N N 246 
LYS C     OXT    sing N N 247 
LYS CB    CG     sing N N 248 
LYS CB    HB2    sing N N 249 
LYS CB    HB3    sing N N 250 
LYS CG    CD     sing N N 251 
LYS CG    HG2    sing N N 252 
LYS CG    HG3    sing N N 253 
LYS CD    CE     sing N N 254 
LYS CD    HD2    sing N N 255 
LYS CD    HD3    sing N N 256 
LYS CE    NZ     sing N N 257 
LYS CE    HE2    sing N N 258 
LYS CE    HE3    sing N N 259 
LYS NZ    HZ1    sing N N 260 
LYS NZ    HZ2    sing N N 261 
LYS NZ    HZ3    sing N N 262 
LYS OXT   HXT    sing N N 263 
MET N     CA     sing N N 264 
MET N     H      sing N N 265 
MET N     H2     sing N N 266 
MET CA    C      sing N N 267 
MET CA    CB     sing N N 268 
MET CA    HA     sing N N 269 
MET C     O      doub N N 270 
MET C     OXT    sing N N 271 
MET CB    CG     sing N N 272 
MET CB    HB2    sing N N 273 
MET CB    HB3    sing N N 274 
MET CG    SD     sing N N 275 
MET CG    HG2    sing N N 276 
MET CG    HG3    sing N N 277 
MET SD    CE     sing N N 278 
MET CE    HE1    sing N N 279 
MET CE    HE2    sing N N 280 
MET CE    HE3    sing N N 281 
MET OXT   HXT    sing N N 282 
PHE N     CA     sing N N 283 
PHE N     H      sing N N 284 
PHE N     H2     sing N N 285 
PHE CA    C      sing N N 286 
PHE CA    CB     sing N N 287 
PHE CA    HA     sing N N 288 
PHE C     O      doub N N 289 
PHE C     OXT    sing N N 290 
PHE CB    CG     sing N N 291 
PHE CB    HB2    sing N N 292 
PHE CB    HB3    sing N N 293 
PHE CG    CD1    doub Y N 294 
PHE CG    CD2    sing Y N 295 
PHE CD1   CE1    sing Y N 296 
PHE CD1   HD1    sing N N 297 
PHE CD2   CE2    doub Y N 298 
PHE CD2   HD2    sing N N 299 
PHE CE1   CZ     doub Y N 300 
PHE CE1   HE1    sing N N 301 
PHE CE2   CZ     sing Y N 302 
PHE CE2   HE2    sing N N 303 
PHE CZ    HZ     sing N N 304 
PHE OXT   HXT    sing N N 305 
PRO N     CA     sing N N 306 
PRO N     CD     sing N N 307 
PRO N     H      sing N N 308 
PRO CA    C      sing N N 309 
PRO CA    CB     sing N N 310 
PRO CA    HA     sing N N 311 
PRO C     O      doub N N 312 
PRO C     OXT    sing N N 313 
PRO CB    CG     sing N N 314 
PRO CB    HB2    sing N N 315 
PRO CB    HB3    sing N N 316 
PRO CG    CD     sing N N 317 
PRO CG    HG2    sing N N 318 
PRO CG    HG3    sing N N 319 
PRO CD    HD2    sing N N 320 
PRO CD    HD3    sing N N 321 
PRO OXT   HXT    sing N N 322 
SER N     CA     sing N N 323 
SER N     H      sing N N 324 
SER N     H2     sing N N 325 
SER CA    C      sing N N 326 
SER CA    CB     sing N N 327 
SER CA    HA     sing N N 328 
SER C     O      doub N N 329 
SER C     OXT    sing N N 330 
SER CB    OG     sing N N 331 
SER CB    HB2    sing N N 332 
SER CB    HB3    sing N N 333 
SER OG    HG     sing N N 334 
SER OXT   HXT    sing N N 335 
THR N     CA     sing N N 336 
THR N     H      sing N N 337 
THR N     H2     sing N N 338 
THR CA    C      sing N N 339 
THR CA    CB     sing N N 340 
THR CA    HA     sing N N 341 
THR C     O      doub N N 342 
THR C     OXT    sing N N 343 
THR CB    OG1    sing N N 344 
THR CB    CG2    sing N N 345 
THR CB    HB     sing N N 346 
THR OG1   HG1    sing N N 347 
THR CG2   HG21   sing N N 348 
THR CG2   HG22   sing N N 349 
THR CG2   HG23   sing N N 350 
THR OXT   HXT    sing N N 351 
TRP N     CA     sing N N 352 
TRP N     H      sing N N 353 
TRP N     H2     sing N N 354 
TRP CA    C      sing N N 355 
TRP CA    CB     sing N N 356 
TRP CA    HA     sing N N 357 
TRP C     O      doub N N 358 
TRP C     OXT    sing N N 359 
TRP CB    CG     sing N N 360 
TRP CB    HB2    sing N N 361 
TRP CB    HB3    sing N N 362 
TRP CG    CD1    doub Y N 363 
TRP CG    CD2    sing Y N 364 
TRP CD1   NE1    sing Y N 365 
TRP CD1   HD1    sing N N 366 
TRP CD2   CE2    doub Y N 367 
TRP CD2   CE3    sing Y N 368 
TRP NE1   CE2    sing Y N 369 
TRP NE1   HE1    sing N N 370 
TRP CE2   CZ2    sing Y N 371 
TRP CE3   CZ3    doub Y N 372 
TRP CE3   HE3    sing N N 373 
TRP CZ2   CH2    doub Y N 374 
TRP CZ2   HZ2    sing N N 375 
TRP CZ3   CH2    sing Y N 376 
TRP CZ3   HZ3    sing N N 377 
TRP CH2   HH2    sing N N 378 
TRP OXT   HXT    sing N N 379 
TYR N     CA     sing N N 380 
TYR N     H      sing N N 381 
TYR N     H2     sing N N 382 
TYR CA    C      sing N N 383 
TYR CA    CB     sing N N 384 
TYR CA    HA     sing N N 385 
TYR C     O      doub N N 386 
TYR C     OXT    sing N N 387 
TYR CB    CG     sing N N 388 
TYR CB    HB2    sing N N 389 
TYR CB    HB3    sing N N 390 
TYR CG    CD1    doub Y N 391 
TYR CG    CD2    sing Y N 392 
TYR CD1   CE1    sing Y N 393 
TYR CD1   HD1    sing N N 394 
TYR CD2   CE2    doub Y N 395 
TYR CD2   HD2    sing N N 396 
TYR CE1   CZ     doub Y N 397 
TYR CE1   HE1    sing N N 398 
TYR CE2   CZ     sing Y N 399 
TYR CE2   HE2    sing N N 400 
TYR CZ    OH     sing N N 401 
TYR OH    HH     sing N N 402 
TYR OXT   HXT    sing N N 403 
VAL N     CA     sing N N 404 
VAL N     H      sing N N 405 
VAL N     H2     sing N N 406 
VAL CA    C      sing N N 407 
VAL CA    CB     sing N N 408 
VAL CA    HA     sing N N 409 
VAL C     O      doub N N 410 
VAL C     OXT    sing N N 411 
VAL CB    CG1    sing N N 412 
VAL CB    CG2    sing N N 413 
VAL CB    HB     sing N N 414 
VAL CG1   HG11   sing N N 415 
VAL CG1   HG12   sing N N 416 
VAL CG1   HG13   sing N N 417 
VAL CG2   HG21   sing N N 418 
VAL CG2   HG22   sing N N 419 
VAL CG2   HG23   sing N N 420 
VAL OXT   HXT    sing N N 421 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           111-2311-B-039-001-MY3 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8YSS 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YSU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028278 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.005198 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008968 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021642 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H  1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
MG 12 12 5.427  2.828  2.176 79.261 1.228 0.381  2.310 7.194  0.859   
N  7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O  8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
P  15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491 68.164 1.115   
S  16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N     . MET A 1 1   ? 10.552  -23.370 24.534  1.000 64.976  0 1   MET A N     1 ? 
ATOM   2    C  CA    . MET A 1 1   ? 11.381  -22.874 23.375  1.000 63.397  0 1   MET A CA    1 ? 
ATOM   3    C  C     . MET A 1 1   ? 12.729  -23.611 23.352  1.000 58.266  0 1   MET A C     1 ? 
ATOM   4    O  O     . MET A 1 1   ? 13.291  -23.873 24.442  1.000 60.054  0 1   MET A O     1 ? 
ATOM   5    C  CB    . MET A 1 1   ? 11.623  -21.363 23.459  1.000 69.817  0 1   MET A CB    1 ? 
ATOM   6    C  CG    . MET A 1 1   ? 12.343  -20.913 24.730  1.000 80.039  0 1   MET A CG    1 ? 
ATOM   7    S  SD    . MET A 1 1   ? 11.268  -20.885 26.202  1.000 93.560  0 1   MET A SD    1 ? 
ATOM   8    C  CE    . MET A 1 1   ? 11.168  -19.127 26.551  1.000 84.184  0 1   MET A CE    1 ? 
ATOM   9    N  N     . ALA A 1 2   ? 13.215  -23.947 22.151  1.000 46.659  0 2   ALA A N     1 ? 
ATOM   10   C  CA    . ALA A 1 2   ? 14.527  -24.587 21.898  1.000 42.805  0 2   ALA A CA    1 ? 
ATOM   11   C  C     . ALA A 1 2   ? 15.649  -23.616 22.276  1.000 40.000  0 2   ALA A C     1 ? 
ATOM   12   O  O     . ALA A 1 2   ? 15.448  -22.402 22.321  1.000 33.372  0 2   ALA A O     1 ? 
ATOM   13   C  CB    . ALA A 1 2   ? 14.606  -25.012 20.454  1.000 41.838  0 2   ALA A CB    1 ? 
ATOM   14   N  N     . PRO A 1 3   ? 16.864  -24.113 22.598  1.000 37.391  0 3   PRO A N     1 ? 
ATOM   15   C  CA    . PRO A 1 3   ? 17.927  -23.249 23.123  1.000 34.374  0 3   PRO A CA    1 ? 
ATOM   16   C  C     . PRO A 1 3   ? 18.230  -22.007 22.264  1.000 27.826  0 3   PRO A C     1 ? 
ATOM   17   O  O     . PRO A 1 3   ? 18.258  -20.896 22.780  1.000 23.310  0 3   PRO A O     1 ? 
ATOM   18   C  CB    . PRO A 1 3   ? 19.161  -24.171 23.149  1.000 36.545  0 3   PRO A CB    1 ? 
ATOM   19   C  CG    . PRO A 1 3   ? 18.598  -25.594 23.209  1.000 37.919  0 3   PRO A CG    1 ? 
ATOM   20   C  CD    . PRO A 1 3   ? 17.253  -25.533 22.522  1.000 38.248  0 3   PRO A CD    1 ? 
ATOM   21   N  N     . VAL A 1 4   ? 18.504  -22.208 20.980  1.000 24.451  0 4   VAL A N     1 ? 
ATOM   22   C  CA    . VAL A 1 4   ? 18.941  -21.083 20.092  1.000 23.679  0 4   VAL A CA    1 ? 
ATOM   23   C  C     . VAL A 1 4   ? 17.769  -20.104 19.906  1.000 19.885  0 4   VAL A C     1 ? 
ATOM   24   O  O     . VAL A 1 4   ? 18.001  -18.918 20.017  1.000 18.578  0 4   VAL A O     1 ? 
ATOM   25   C  CB    . VAL A 1 4   ? 19.503  -21.595 18.761  1.000 26.153  0 4   VAL A CB    1 ? 
ATOM   26   C  CG1   . VAL A 1 4   ? 18.595  -22.642 18.154  1.000 28.936  0 4   VAL A CG1   1 ? 
ATOM   27   C  CG2   . VAL A 1 4   ? 19.770  -20.465 17.773  1.000 24.745  0 4   VAL A CG2   1 ? 
ATOM   28   N  N     . GLN A 1 5   ? 16.537  -20.607 19.764  1.000 18.244  0 5   GLN A N     1 ? 
ATOM   29   C  CA    . GLN A 1 5   ? 15.322  -19.760 19.667  1.000 18.597  0 5   GLN A CA    1 ? 
ATOM   30   C  C     . GLN A 1 5   ? 15.270  -18.812 20.873  1.000 19.487  0 5   GLN A C     1 ? 
ATOM   31   O  O     . GLN A 1 5   ? 14.927  -17.637 20.676  1.000 18.509  0 5   GLN A O     1 ? 
ATOM   32   C  CB    . GLN A 1 5   ? 14.033  -20.586 19.573  1.000 19.157  0 5   GLN A CB    1 ? 
ATOM   33   C  CG    . GLN A 1 5   ? 12.755  -19.726 19.430  1.000 19.138  0 5   GLN A CG    1 ? 
ATOM   34   C  CD    . GLN A 1 5   ? 12.677  -18.890 18.167  1.000 18.443  0 5   GLN A CD    1 ? 
ATOM   35   O  OE1   . GLN A 1 5   ? 11.777  -18.063 17.953  1.000 17.112  0 5   GLN A OE1   1 ? 
ATOM   36   N  NE2   . GLN A 1 5   ? 13.617  -19.108 17.290  1.000 16.712  0 5   GLN A NE2   1 ? 
ATOM   37   N  N     . LYS A 1 6   ? 15.621  -19.306 22.064  1.000 18.117  0 6   LYS A N     1 ? 
ATOM   38   C  CA    . LYS A 1 6   ? 15.595  -18.508 23.306  1.000 20.516  0 6   LYS A CA    1 ? 
ATOM   39   C  C     . LYS A 1 6   ? 16.565  -17.330 23.183  1.000 18.498  0 6   LYS A C     1 ? 
ATOM   40   O  O     . LYS A 1 6   ? 16.251  -16.238 23.697  1.000 16.672  0 6   LYS A O     1 ? 
ATOM   41   C  CB    . LYS A 1 6   ? 16.016  -19.391 24.476  1.000 23.930  0 6   LYS A CB    1 ? 
ATOM   42   C  CG    . LYS A 1 6   ? 15.318  -19.109 25.790  1.000 29.642  0 6   LYS A CG    1 ? 
ATOM   43   C  CD    . LYS A 1 6   ? 15.542  -20.260 26.762  1.000 34.687  0 6   LYS A CD    1 ? 
ATOM   44   C  CE    . LYS A 1 6   ? 14.623  -20.236 27.965  1.000 40.601  0 6   LYS A CE    1 ? 
ATOM   45   N  NZ    . LYS A 1 6   ? 14.725  -21.495 28.746  1.000 41.949  0 6   LYS A NZ    1 ? 
ATOM   46   N  N     . GLN A 1 7   ? 17.740  -17.583 22.594  1.000 17.764  0 7   GLN A N     1 ? 
ATOM   47   C  CA    . GLN A 1 7   ? 18.816  -16.579 22.458  1.000 17.706  0 7   GLN A CA    1 ? 
ATOM   48   C  C     . GLN A 1 7   ? 18.379  -15.528 21.429  1.000 17.396  0 7   GLN A C     1 ? 
ATOM   49   O  O     . GLN A 1 7   ? 18.639  -14.339 21.647  1.000 16.383  0 7   GLN A O     1 ? 
ATOM   50   C  CB    . GLN A 1 7   ? 20.132  -17.270 22.085  1.000 20.449  0 7   GLN A CB    1 ? 
ATOM   51   C  CG    . GLN A 1 7   ? 20.479  -18.492 22.954  1.000 22.290  0 7   GLN A CG    1 ? 
ATOM   52   C  CD    . GLN A 1 7   ? 20.735  -18.176 24.402  1.000 25.716  0 7   GLN A CD    1 ? 
ATOM   53   O  OE1   . GLN A 1 7   ? 20.178  -18.823 25.291  1.000 30.726  0 7   GLN A OE1   1 ? 
ATOM   54   N  NE2   . GLN A 1 7   ? 21.651  -17.243 24.655  1.000 25.883  0 7   GLN A NE2   1 ? 
ATOM   55   N  N     . PHE A 1 8   ? 17.751  -15.961 20.333  1.000 15.744  0 8   PHE A N     1 ? 
ATOM   56   C  CA    . PHE A 1 8   ? 17.247  -15.043 19.286  1.000 15.792  0 8   PHE A CA    1 ? 
ATOM   57   C  C     . PHE A 1 8   ? 16.131  -14.170 19.867  1.000 14.208  0 8   PHE A C     1 ? 
ATOM   58   O  O     . PHE A 1 8   ? 16.143  -12.967 19.638  1.000 14.417  0 8   PHE A O     1 ? 
ATOM   59   C  CB    . PHE A 1 8   ? 16.775  -15.810 18.057  1.000 16.282  0 8   PHE A CB    1 ? 
ATOM   60   C  CG    . PHE A 1 8   ? 17.800  -15.900 16.966  1.000 17.501  0 8   PHE A CG    1 ? 
ATOM   61   C  CD1   . PHE A 1 8   ? 18.087  -14.792 16.179  1.000 18.290  0 8   PHE A CD1   1 ? 
ATOM   62   C  CD2   . PHE A 1 8   ? 18.446  -17.096 16.684  1.000 19.052  0 8   PHE A CD2   1 ? 
ATOM   63   C  CE1   . PHE A 1 8   ? 19.023  -14.867 15.165  1.000 18.876  0 8   PHE A CE1   1 ? 
ATOM   64   C  CE2   . PHE A 1 8   ? 19.368  -17.170 15.649  1.000 18.988  0 8   PHE A CE2   1 ? 
ATOM   65   C  CZ    . PHE A 1 8   ? 19.644  -16.064 14.887  1.000 18.706  0 8   PHE A CZ    1 ? 
ATOM   66   N  N     . ARG A 1 9   ? 15.209  -14.748 20.626  1.000 13.257  0 9   ARG A N     1 ? 
ATOM   67   C  CA    . ARG A 1 9   ? 14.131  -13.955 21.268  1.000 14.238  0 9   ARG A CA    1 ? 
ATOM   68   C  C     . ARG A 1 9   ? 14.739  -12.967 22.268  1.000 13.053  0 9   ARG A C     1 ? 
ATOM   69   O  O     . ARG A 1 9   ? 14.235  -11.858 22.315  1.000 13.542  0 9   ARG A O     1 ? 
ATOM   70   C  CB    . ARG A 1 9   ? 13.099  -14.853 21.951  1.000 14.601  0 9   ARG A CB    1 ? 
ATOM   71   C  CG    . ARG A 1 9   ? 12.278  -15.686 20.983  1.000 16.137  0 9   ARG A CG    1 ? 
ATOM   72   C  CD    . ARG A 1 9   ? 11.496  -14.851 19.999  1.000 17.935  0 9   ARG A CD    1 ? 
ATOM   73   N  NE    . ARG A 1 9   ? 10.634  -13.894 20.663  1.000 19.294  0 9   ARG A NE    1 ? 
ATOM   74   C  CZ    . ARG A 1 9   ? 9.342   -14.083 20.921  1.000 21.257  0 9   ARG A CZ    1 ? 
ATOM   75   N  NH1   . ARG A 1 9   ? 8.754   -15.214 20.578  1.000 23.926  0 9   ARG A NH1   1 ? 
ATOM   76   N  NH2   . ARG A 1 9   ? 8.640   -13.143 21.531  1.000 20.799  0 9   ARG A NH2   1 ? 
ATOM   77   N  N     . GLU A 1 10  ? 15.795  -13.329 23.011  1.000 13.383  0 10  GLU A N     1 ? 
ATOM   78   C  CA    . GLU A 1 10  ? 16.463  -12.363 23.938  1.000 13.141  0 10  GLU A CA    1 ? 
ATOM   79   C  C     . GLU A 1 10  ? 17.105  -11.236 23.120  1.000 13.630  0 10  GLU A C     1 ? 
ATOM   80   O  O     . GLU A 1 10  ? 16.937  -10.034 23.459  1.000 14.211  0 10  GLU A O     1 ? 
ATOM   81   C  CB    . GLU A 1 10  ? 17.517  -13.023 24.824  1.000 12.667  0 10  GLU A CB    1 ? 
ATOM   82   C  CG    . GLU A 1 10  ? 18.339  -12.015 25.643  1.000 12.579  0 10  GLU A CG    1 ? 
ATOM   83   C  CD    . GLU A 1 10  ? 17.590  -11.281 26.752  1.000 13.498  0 10  GLU A CD    1 ? 
ATOM   84   O  OE1   . GLU A 1 10  ? 16.517  -11.786 27.182  1.000 12.851  0 10  GLU A OE1   1 ? 
ATOM   85   O  OE2   . GLU A 1 10  ? 18.048  -10.209 27.169  1.000 13.627  0 10  GLU A OE2   1 ? 
ATOM   86   N  N     . PHE A 1 11  ? 17.830  -11.597 22.065  1.000 14.345  0 11  PHE A N     1 ? 
ATOM   87   C  CA    . PHE A 1 11  ? 18.461  -10.610 21.168  1.000 14.535  0 11  PHE A CA    1 ? 
ATOM   88   C  C     . PHE A 1 11  ? 17.379  -9.635  20.716  1.000 14.252  0 11  PHE A C     1 ? 
ATOM   89   O  O     . PHE A 1 11  ? 17.554  -8.408  20.820  1.000 14.111  0 11  PHE A O     1 ? 
ATOM   90   C  CB    . PHE A 1 11  ? 19.093  -11.340 19.994  1.000 14.843  0 11  PHE A CB    1 ? 
ATOM   91   C  CG    . PHE A 1 11  ? 19.807  -10.473 18.994  1.000 15.844  0 11  PHE A CG    1 ? 
ATOM   92   C  CD1   . PHE A 1 11  ? 20.724  -9.516  19.404  1.000 15.747  0 11  PHE A CD1   1 ? 
ATOM   93   C  CD2   . PHE A 1 11  ? 19.635  -10.684 17.634  1.000 15.690  0 11  PHE A CD2   1 ? 
ATOM   94   C  CE1   . PHE A 1 11  ? 21.396  -8.738  18.481  1.000 15.253  0 11  PHE A CE1   1 ? 
ATOM   95   C  CE2   . PHE A 1 11  ? 20.328  -9.918  16.709  1.000 16.423  0 11  PHE A CE2   1 ? 
ATOM   96   C  CZ    . PHE A 1 11  ? 21.213  -8.953  17.134  1.000 16.590  0 11  PHE A CZ    1 ? 
ATOM   97   N  N     . HIS A 1 12  ? 16.264  -10.172 20.201  1.000 14.928  0 12  HIS A N     1 ? 
ATOM   98   C  CA    . HIS A 1 12  ? 15.169  -9.326  19.670  1.000 14.769  0 12  HIS A CA    1 ? 
ATOM   99   C  C     . HIS A 1 12  ? 14.747  -8.338  20.735  1.000 14.301  0 12  HIS A C     1 ? 
ATOM   100  O  O     . HIS A 1 12  ? 14.490  -7.197  20.388  1.000 15.722  0 12  HIS A O     1 ? 
ATOM   101  C  CB    . HIS A 1 12  ? 13.950  -10.152 19.251  1.000 15.250  0 12  HIS A CB    1 ? 
ATOM   102  C  CG    . HIS A 1 12  ? 12.860  -9.275  18.724  1.000 13.794  0 12  HIS A CG    1 ? 
ATOM   103  N  ND1   . HIS A 1 12  ? 11.662  -9.194  19.334  1.000 13.659  0 12  HIS A ND1   1 ? 
ATOM   104  C  CD2   . HIS A 1 12  ? 12.810  -8.436  17.674  1.000 13.265  0 12  HIS A CD2   1 ? 
ATOM   105  C  CE1   . HIS A 1 12  ? 10.908  -8.322  18.698  1.000 13.776  0 12  HIS A CE1   1 ? 
ATOM   106  N  NE2   . HIS A 1 12  ? 11.577  -7.861  17.660  1.000 13.474  0 12  HIS A NE2   1 ? 
ATOM   107  N  N     . ASP A 1 13  ? 14.605  -8.812  21.978  1.000 14.728  0 13  ASP A N     1 ? 
ATOM   108  C  CA    . ASP A 1 13  ? 14.214  -7.984  23.149  1.000 14.337  0 13  ASP A CA    1 ? 
ATOM   109  C  C     . ASP A 1 13  ? 15.214  -6.852  23.388  1.000 13.900  0 13  ASP A C     1 ? 
ATOM   110  O  O     . ASP A 1 13  ? 14.796  -5.787  23.828  1.000 14.216  0 13  ASP A O     1 ? 
ATOM   111  C  CB    . ASP A 1 13  ? 14.054  -8.846  24.397  1.000 15.004  0 13  ASP A CB    1 ? 
ATOM   112  C  CG    . ASP A 1 13  ? 12.707  -9.550  24.403  1.000 15.097  0 13  ASP A CG    1 ? 
ATOM   113  O  OD1   . ASP A 1 13  ? 11.815  -9.165  23.601  1.000 16.499  0 13  ASP A OD1   1 ? 
ATOM   114  O  OD2   . ASP A 1 13  ? 12.594  -10.510 25.123  1.000 16.568  0 13  ASP A OD2   1 ? 
ATOM   115  N  N     . ARG A 1 14  ? 16.493  -7.089  23.140  1.000 14.220  0 14  ARG A N     1 ? 
ATOM   116  C  CA    . ARG A 1 14  ? 17.549  -6.086  23.381  1.000 15.725  0 14  ARG A CA    1 ? 
ATOM   117  C  C     . ARG A 1 14  ? 17.540  -5.027  22.263  1.000 15.787  0 14  ARG A C     1 ? 
ATOM   118  O  O     . ARG A 1 14  ? 17.840  -3.881  22.559  1.000 16.951  0 14  ARG A O     1 ? 
ATOM   119  C  CB    . ARG A 1 14  ? 18.904  -6.797  23.467  1.000 17.433  0 14  ARG A CB    1 ? 
ATOM   120  C  CG    . ARG A 1 14  ? 19.049  -7.720  24.670  1.000 17.041  0 14  ARG A CG    1 ? 
ATOM   121  C  CD    . ARG A 1 14  ? 20.404  -8.373  24.716  1.000 17.463  0 14  ARG A CD    1 ? 
ATOM   122  N  NE    . ARG A 1 14  ? 20.573  -9.168  25.919  1.000 17.007  0 14  ARG A NE    1 ? 
ATOM   123  C  CZ    . ARG A 1 14  ? 21.634  -9.925  26.182  1.000 17.933  0 14  ARG A CZ    1 ? 
ATOM   124  N  NH1   . ARG A 1 14  ? 22.629  -9.971  25.317  1.000 15.755  0 14  ARG A NH1   1 ? 
ATOM   125  N  NH2   . ARG A 1 14  ? 21.698  -10.609 27.323  1.000 18.114  0 14  ARG A NH2   1 ? 
ATOM   126  N  N     . ILE A 1 15  ? 17.253  -5.398  21.014  1.000 15.460  0 15  ILE A N     1 ? 
ATOM   127  C  CA    . ILE A 1 15  ? 17.431  -4.484  19.848  1.000 15.852  0 15  ILE A CA    1 ? 
ATOM   128  C  C     . ILE A 1 15  ? 16.107  -3.796  19.505  1.000 17.315  0 15  ILE A C     1 ? 
ATOM   129  O  O     . ILE A 1 15  ? 16.163  -2.775  18.786  1.000 18.000  0 15  ILE A O     1 ? 
ATOM   130  C  CB    . ILE A 1 15  ? 18.002  -5.244  18.632  1.000 14.726  0 15  ILE A CB    1 ? 
ATOM   131  C  CG1   . ILE A 1 15  ? 16.939  -6.126  17.978  1.000 15.000  0 15  ILE A CG1   1 ? 
ATOM   132  C  CG2   . ILE A 1 15  ? 19.236  -6.038  19.035  1.000 14.943  0 15  ILE A CG2   1 ? 
ATOM   133  C  CD1   . ILE A 1 15  ? 17.420  -6.865  16.730  1.000 16.683  0 15  ILE A CD1   1 ? 
ATOM   134  N  N     . LYS A 1 16  ? 14.963  -4.302  19.977  1.000 17.743  0 16  LYS A N     1 ? 
ATOM   135  C  CA    . LYS A 1 16  ? 13.667  -3.775  19.486  1.000 19.558  0 16  LYS A CA    1 ? 
ATOM   136  C  C     . LYS A 1 16  ? 13.433  -2.377  20.069  1.000 19.825  0 16  LYS A C     1 ? 
ATOM   137  O  O     . LYS A 1 16  ? 13.835  -2.113  21.185  1.000 19.336  0 16  LYS A O     1 ? 
ATOM   138  C  CB    . LYS A 1 16  ? 12.506  -4.727  19.792  1.000 20.678  0 16  LYS A CB    1 ? 
ATOM   139  C  CG    . LYS A 1 16  ? 12.141  -4.823  21.263  1.000 22.748  0 16  LYS A CG    1 ? 
ATOM   140  C  CD    . LYS A 1 16  ? 11.147  -5.905  21.567  1.000 25.151  0 16  LYS A CD    1 ? 
ATOM   141  C  CE    . LYS A 1 16  ? 10.771  -5.952  23.032  1.000 26.147  0 16  LYS A CE    1 ? 
ATOM   142  N  NZ    . LYS A 1 16  ? 10.149  -7.253  23.384  1.000 27.255  0 16  LYS A NZ    1 ? 
ATOM   143  N  N     . LEU A 1 17  ? 12.786  -1.505  19.304  1.000 19.787  0 17  LEU A N     1 ? 
ATOM   144  C  CA    . LEU A 1 17  ? 12.387  -0.154  19.755  1.000 21.762  0 17  LEU A CA    1 ? 
ATOM   145  C  C     . LEU A 1 17  ? 10.873  -0.041  19.626  1.000 21.227  0 17  LEU A C     1 ? 
ATOM   146  O  O     . LEU A 1 17  ? 10.352  -0.420  18.552  1.000 24.600  0 17  LEU A O     1 ? 
ATOM   147  C  CB    . LEU A 1 17  ? 13.095  0.902   18.893  1.000 22.268  0 17  LEU A CB    1 ? 
ATOM   148  C  CG    . LEU A 1 17  ? 12.846  2.348   19.309  1.000 21.320  0 17  LEU A CG    1 ? 
ATOM   149  C  CD1   . LEU A 1 17  ? 13.369  2.608   20.704  1.000 23.447  0 17  LEU A CD1   1 ? 
ATOM   150  C  CD2   . LEU A 1 17  ? 13.474  3.316   18.326  1.000 22.802  0 17  LEU A CD2   1 ? 
ATOM   151  N  N     . ALA A 1 18  ? 10.184  0.388   20.688  1.000 21.208  0 18  ALA A N     1 ? 
ATOM   152  C  CA    . ALA A 1 18  ? 8.714   0.534   20.692  1.000 21.035  0 18  ALA A CA    1 ? 
ATOM   153  C  C     . ALA A 1 18  ? 8.314   1.430   19.506  1.000 17.593  0 18  ALA A C     1 ? 
ATOM   154  O  O     . ALA A 1 18  ? 8.994   2.421   19.245  1.000 18.630  0 18  ALA A O     1 ? 
ATOM   155  C  CB    . ALA A 1 18  ? 8.223   1.070   22.024  1.000 22.639  0 18  ALA A CB    1 ? 
ATOM   156  N  N     . GLN A 1 19  ? 7.267   1.044   18.797  1.000 17.973  0 19  GLN A N     1 ? 
ATOM   157  C  CA    . GLN A 1 19  ? 6.677   1.786   17.654  1.000 18.676  0 19  GLN A CA    1 ? 
ATOM   158  C  C     . GLN A 1 19  ? 5.986   3.058   18.189  1.000 19.999  0 19  GLN A C     1 ? 
ATOM   159  O  O     . GLN A 1 19  ? 5.692   3.094   19.408  1.000 18.155  0 19  GLN A O     1 ? 
ATOM   160  C  CB    . GLN A 1 19  ? 5.682   0.860   16.965  1.000 19.486  0 19  GLN A CB    1 ? 
ATOM   161  C  CG    . GLN A 1 19  ? 4.411   0.678   17.788  1.000 21.251  0 19  GLN A CG    1 ? 
ATOM   162  C  CD    . GLN A 1 19  ? 3.396   -0.196  17.106  1.000 21.934  0 19  GLN A CD    1 ? 
ATOM   163  O  OE1   . GLN A 1 19  ? 2.947   0.084   16.000  1.000 22.916  0 19  GLN A OE1   1 ? 
ATOM   164  N  NE2   . GLN A 1 19  ? 3.010   -1.260  17.779  1.000 22.647  0 19  GLN A NE2   1 ? 
ATOM   165  N  N     . TYR A 1 20  ? 5.676   4.028   17.316  1.000 19.634  0 20  TYR A N     1 ? 
ATOM   166  C  CA    . TYR A 1 20  ? 5.067   5.339   17.680  1.000 22.395  0 20  TYR A CA    1 ? 
ATOM   167  C  C     . TYR A 1 20  ? 3.941   5.134   18.710  1.000 22.935  0 20  TYR A C     1 ? 
ATOM   168  O  O     . TYR A 1 20  ? 4.001   5.737   19.783  1.000 22.910  0 20  TYR A O     1 ? 
ATOM   169  C  CB    . TYR A 1 20  ? 4.558   6.085   16.440  1.000 21.945  0 20  TYR A CB    1 ? 
ATOM   170  C  CG    . TYR A 1 20  ? 5.611   6.807   15.615  1.000 22.078  0 20  TYR A CG    1 ? 
ATOM   171  C  CD1   . TYR A 1 20  ? 6.474   7.734   16.177  1.000 23.418  0 20  TYR A CD1   1 ? 
ATOM   172  C  CD2   . TYR A 1 20  ? 5.738   6.563   14.251  1.000 21.772  0 20  TYR A CD2   1 ? 
ATOM   173  C  CE1   . TYR A 1 20  ? 7.403   8.425   15.402  1.000 23.814  0 20  TYR A CE1   1 ? 
ATOM   174  C  CE2   . TYR A 1 20  ? 6.678   7.214   13.468  1.000 22.180  0 20  TYR A CE2   1 ? 
ATOM   175  C  CZ    . TYR A 1 20  ? 7.518   8.153   14.042  1.000 24.387  0 20  TYR A CZ    1 ? 
ATOM   176  O  OH    . TYR A 1 20  ? 8.468   8.777   13.275  1.000 24.881  0 20  TYR A OH    1 ? 
ATOM   177  N  N     . ASP A 1 21  ? 2.983   4.264   18.399  1.000 28.179  0 21  ASP A N     1 ? 
ATOM   178  C  CA    . ASP A 1 21  ? 1.780   3.973   19.234  1.000 31.544  0 21  ASP A CA    1 ? 
ATOM   179  C  C     . ASP A 1 21  ? 2.148   3.465   20.631  1.000 31.308  0 21  ASP A C     1 ? 
ATOM   180  O  O     . ASP A 1 21  ? 1.243   3.451   21.476  1.000 30.776  0 21  ASP A O     1 ? 
ATOM   181  C  CB    . ASP A 1 21  ? 0.902   2.879   18.612  1.000 33.488  0 21  ASP A CB    1 ? 
ATOM   182  C  CG    . ASP A 1 21  ? -0.119  3.425   17.637  1.000 37.877  0 21  ASP A CG    1 ? 
ATOM   183  O  OD1   . ASP A 1 21  ? -1.120  2.729   17.373  1.000 43.524  0 21  ASP A OD1   1 ? 
ATOM   184  O  OD2   . ASP A 1 21  ? 0.101   4.542   17.147  1.000 44.583  0 21  ASP A OD2   1 ? 
ATOM   185  N  N     . GLU A 1 22  ? 3.379   2.997   20.855  1.000 26.822  0 22  GLU A N     1 ? 
ATOM   186  C  CA    . GLU A 1 22  ? 3.784   2.407   22.150  1.000 27.453  0 22  GLU A CA    1 ? 
ATOM   187  C  C     . GLU A 1 22  ? 4.954   3.189   22.750  1.000 28.520  0 22  GLU A C     1 ? 
ATOM   188  O  O     . GLU A 1 22  ? 5.571   2.661   23.659  1.000 30.966  0 22  GLU A O     1 ? 
ATOM   189  C  CB    . GLU A 1 22  ? 4.168   0.944   21.949  1.000 27.834  0 22  GLU A CB    1 ? 
ATOM   190  C  CG    . GLU A 1 22  ? 3.026   0.068   21.453  1.000 29.320  0 22  GLU A CG    1 ? 
ATOM   191  C  CD    . GLU A 1 22  ? 3.382   -1.403  21.291  1.000 32.476  0 22  GLU A CD    1 ? 
ATOM   192  O  OE1   . GLU A 1 22  ? 3.923   -1.996  22.245  1.000 34.970  0 22  GLU A OE1   1 ? 
ATOM   193  O  OE2   . GLU A 1 22  ? 3.159   -1.944  20.209  1.000 33.866  0 22  GLU A OE2   1 ? 
ATOM   194  N  N     . ASN A 1 23  ? 5.278   4.390   22.263  1.000 26.335  0 23  ASN A N     1 ? 
ATOM   195  C  CA    . ASN A 1 23  ? 6.554   5.061   22.631  1.000 26.363  0 23  ASN A CA    1 ? 
ATOM   196  C  C     . ASN A 1 23  ? 6.342   6.564   22.906  1.000 29.818  0 23  ASN A C     1 ? 
ATOM   197  O  O     . ASN A 1 23  ? 6.468   7.392   21.976  1.000 30.489  0 23  ASN A O     1 ? 
ATOM   198  C  CB    . ASN A 1 23  ? 7.580   4.798   21.534  1.000 25.219  0 23  ASN A CB    1 ? 
ATOM   199  C  CG    . ASN A 1 23  ? 8.984   5.113   21.958  1.000 23.338  0 23  ASN A CG    1 ? 
ATOM   200  O  OD1   . ASN A 1 23  ? 9.193   6.001   22.772  1.000 25.481  0 23  ASN A OD1   1 ? 
ATOM   201  N  ND2   . ASN A 1 23  ? 9.945   4.359   21.440  1.000 23.033  0 23  ASN A ND2   1 ? 
ATOM   202  N  N     . GLN A 1 24  ? 6.075   6.936   24.147  1.000 30.962  0 24  GLN A N     1 ? 
ATOM   203  C  CA    . GLN A 1 24  ? 5.749   8.343   24.507  1.000 35.348  0 24  GLN A CA    1 ? 
ATOM   204  C  C     . GLN A 1 24  ? 6.815   9.256   23.918  1.000 32.081  0 24  GLN A C     1 ? 
ATOM   205  O  O     . GLN A 1 24  ? 6.467   10.330  23.347  1.000 30.524  0 24  GLN A O     1 ? 
ATOM   206  C  CB    . GLN A 1 24  ? 5.686   8.541   26.022  1.000 40.167  0 24  GLN A CB    1 ? 
ATOM   207  C  CG    . GLN A 1 24  ? 4.285   8.845   26.529  1.000 50.483  0 24  GLN A CG    1 ? 
ATOM   208  C  CD    . GLN A 1 24  ? 3.791   10.231  26.179  1.000 54.529  0 24  GLN A CD    1 ? 
ATOM   209  O  OE1   . GLN A 1 24  ? 4.352   10.936  25.338  1.000 54.955  0 24  GLN A OE1   1 ? 
ATOM   210  N  NE2   . GLN A 1 24  ? 2.710   10.631  26.833  1.000 58.881  0 24  GLN A NE2   1 ? 
ATOM   211  N  N     . THR A 1 25  ? 8.068   8.839   24.061  1.000 30.238  0 25  THR A N     1 ? 
ATOM   212  C  CA    . THR A 1 25  ? 9.269   9.647   23.742  1.000 30.113  0 25  THR A CA    1 ? 
ATOM   213  C  C     . THR A 1 25  ? 9.249   10.006  22.248  1.000 30.169  0 25  THR A C     1 ? 
ATOM   214  O  O     . THR A 1 25  ? 9.384   11.203  21.908  1.000 32.531  0 25  THR A O     1 ? 
ATOM   215  C  CB    . THR A 1 25  ? 10.515  8.886   24.192  1.000 33.738  0 25  THR A CB    1 ? 
ATOM   216  O  OG1   . THR A 1 25  ? 10.353  8.642   25.592  1.000 34.399  0 25  THR A OG1   1 ? 
ATOM   217  C  CG2   . THR A 1 25  ? 11.805  9.623   23.912  1.000 36.071  0 25  THR A CG2   1 ? 
ATOM   218  N  N     . LEU A 1 26  ? 9.054   9.022   21.379  1.000 27.332  0 26  LEU A N     1 ? 
ATOM   219  C  CA    . LEU A 1 26  ? 9.133   9.253   19.916  1.000 27.353  0 26  LEU A CA    1 ? 
ATOM   220  C  C     . LEU A 1 26  ? 8.079   10.270  19.505  1.000 26.255  0 26  LEU A C     1 ? 
ATOM   221  O  O     . LEU A 1 26  ? 8.428   11.133  18.694  1.000 25.401  0 26  LEU A O     1 ? 
ATOM   222  C  CB    . LEU A 1 26  ? 8.914   7.929   19.195  1.000 26.797  0 26  LEU A CB    1 ? 
ATOM   223  C  CG    . LEU A 1 26  ? 10.060  6.950   19.381  1.000 27.419  0 26  LEU A CG    1 ? 
ATOM   224  C  CD1   . LEU A 1 26  ? 9.762   5.660   18.640  1.000 26.957  0 26  LEU A CD1   1 ? 
ATOM   225  C  CD2   . LEU A 1 26  ? 11.377  7.589   18.929  1.000 26.563  0 26  LEU A CD2   1 ? 
ATOM   226  N  N     . ARG A 1 27  ? 6.848   10.097  20.013  1.000 28.460  0 27  ARG A N     1 ? 
ATOM   227  C  CA    . ARG A 1 27  ? 5.664   10.969  19.764  1.000 29.143  0 27  ARG A CA    1 ? 
ATOM   228  C  C     . ARG A 1 27  ? 5.984   12.402  20.212  1.000 31.053  0 27  ARG A C     1 ? 
ATOM   229  O  O     . ARG A 1 27  ? 5.794   13.350  19.399  1.000 31.097  0 27  ARG A O     1 ? 
ATOM   230  C  CB    . ARG A 1 27  ? 4.421   10.432  20.484  1.000 28.656  0 27  ARG A CB    1 ? 
ATOM   231  C  CG    . ARG A 1 27  ? 3.895   9.106   19.944  1.000 28.239  0 27  ARG A CG    1 ? 
ATOM   232  C  CD    . ARG A 1 27  ? 2.447   8.827   20.335  1.000 30.061  0 27  ARG A CD    1 ? 
ATOM   233  N  NE    . ARG A 1 27  ? 2.258   8.906   21.780  1.000 30.614  0 27  ARG A NE    1 ? 
ATOM   234  C  CZ    . ARG A 1 27  ? 2.387   7.886   22.614  1.000 31.417  0 27  ARG A CZ    1 ? 
ATOM   235  N  NH1   . ARG A 1 27  ? 2.700   6.676   22.164  1.000 32.640  0 27  ARG A NH1   1 ? 
ATOM   236  N  NH2   . ARG A 1 27  ? 2.224   8.086   23.912  1.000 31.630  0 27  ARG A NH2   1 ? 
ATOM   237  N  N     . ASP A 1 28  ? 6.471   12.562  21.443  1.000 31.446  0 28  ASP A N     1 ? 
ATOM   238  C  CA    . ASP A 1 28  ? 6.832   13.885  22.018  1.000 31.873  0 28  ASP A CA    1 ? 
ATOM   239  C  C     . ASP A 1 28  ? 7.959   14.521  21.195  1.000 34.418  0 28  ASP A C     1 ? 
ATOM   240  O  O     . ASP A 1 28  ? 7.906   15.742  20.967  1.000 37.940  0 28  ASP A O     1 ? 
ATOM   241  C  CB    . ASP A 1 28  ? 7.263   13.762  23.475  1.000 30.625  0 28  ASP A CB    1 ? 
ATOM   242  C  CG    . ASP A 1 28  ? 6.144   13.378  24.410  1.000 30.531  0 28  ASP A CG    1 ? 
ATOM   243  O  OD1   . ASP A 1 28  ? 5.005   13.324  23.958  1.000 30.804  0 28  ASP A OD1   1 ? 
ATOM   244  O  OD2   . ASP A 1 28  ? 6.443   13.105  25.589  1.000 34.540  0 28  ASP A OD2   1 ? 
ATOM   245  N  N     . GLU A 1 29  ? 8.961   13.754  20.773  1.000 32.500  0 29  GLU A N     1 ? 
ATOM   246  C  CA    . GLU A 1 29  ? 10.078  14.329  19.986  1.000 31.311  0 29  GLU A CA    1 ? 
ATOM   247  C  C     . GLU A 1 29  ? 9.546   14.665  18.595  1.000 29.652  0 29  GLU A C     1 ? 
ATOM   248  O  O     . GLU A 1 29  ? 9.890   15.721  18.044  1.000 28.695  0 29  GLU A O     1 ? 
ATOM   249  C  CB    . GLU A 1 29  ? 11.257  13.369  19.882  1.000 32.615  0 29  GLU A CB    1 ? 
ATOM   250  C  CG    . GLU A 1 29  ? 12.017  13.179  21.179  1.000 35.356  0 29  GLU A CG    1 ? 
ATOM   251  C  CD    . GLU A 1 29  ? 12.972  12.000  21.124  1.000 35.920  0 29  GLU A CD    1 ? 
ATOM   252  O  OE1   . GLU A 1 29  ? 13.880  11.923  21.969  1.000 34.123  0 29  GLU A OE1   1 ? 
ATOM   253  O  OE2   . GLU A 1 29  ? 12.798  11.157  20.224  1.000 38.747  0 29  GLU A OE2   1 ? 
ATOM   254  N  N     . ARG A 1 30  ? 8.737   13.780  18.041  1.000 30.172  0 30  ARG A N     1 ? 
ATOM   255  C  CA    . ARG A 1 30  ? 8.080   14.018  16.735  1.000 31.338  0 30  ARG A CA    1 ? 
ATOM   256  C  C     . ARG A 1 30  ? 7.240   15.307  16.829  1.000 31.541  0 30  ARG A C     1 ? 
ATOM   257  O  O     . ARG A 1 30  ? 7.373   16.159  15.938  1.000 28.500  0 30  ARG A O     1 ? 
ATOM   258  C  CB    . ARG A 1 30  ? 7.242   12.798  16.349  1.000 29.072  0 30  ARG A CB    1 ? 
ATOM   259  C  CG    . ARG A 1 30  ? 6.364   13.001  15.125  1.000 30.231  0 30  ARG A CG    1 ? 
ATOM   260  C  CD    . ARG A 1 30  ? 5.170   12.083  15.150  1.000 29.620  0 30  ARG A CD    1 ? 
ATOM   261  N  NE    . ARG A 1 30  ? 4.314   12.318  16.309  1.000 29.897  0 30  ARG A NE    1 ? 
ATOM   262  C  CZ    . ARG A 1 30  ? 3.374   11.474  16.731  1.000 30.540  0 30  ARG A CZ    1 ? 
ATOM   263  N  NH1   . ARG A 1 30  ? 3.179   10.331  16.097  1.000 29.584  0 30  ARG A NH1   1 ? 
ATOM   264  N  NH2   . ARG A 1 30  ? 2.622   11.778  17.775  1.000 29.711  0 30  ARG A NH2   1 ? 
ATOM   265  N  N     . ASP A 1 31  ? 6.413   15.432  17.872  1.000 32.395  0 31  ASP A N     1 ? 
ATOM   266  C  CA    . ASP A 1 31  ? 5.449   16.552  18.041  1.000 31.707  0 31  ASP A CA    1 ? 
ATOM   267  C  C     . ASP A 1 31  ? 6.192   17.870  18.247  1.000 32.879  0 31  ASP A C     1 ? 
ATOM   268  O  O     . ASP A 1 31  ? 5.676   18.885  17.766  1.000 33.787  0 31  ASP A O     1 ? 
ATOM   269  C  CB    . ASP A 1 31  ? 4.471   16.263  19.169  1.000 29.687  0 31  ASP A CB    1 ? 
ATOM   270  C  CG    . ASP A 1 31  ? 3.462   15.233  18.729  1.000 30.695  0 31  ASP A CG    1 ? 
ATOM   271  O  OD1   . ASP A 1 31  ? 3.429   14.928  17.508  1.000 35.468  0 31  ASP A OD1   1 ? 
ATOM   272  O  OD2   . ASP A 1 31  ? 2.741   14.740  19.575  1.000 29.312  0 31  ASP A OD2   1 ? 
ATOM   273  N  N     . ALA A 1 32  ? 7.343   17.837  18.927  1.000 34.565  0 32  ALA A N     1 ? 
ATOM   274  C  CA    . ALA A 1 32  ? 8.198   19.015  19.183  1.000 32.522  0 32  ALA A CA    1 ? 
ATOM   275  C  C     . ALA A 1 32  ? 8.550   19.612  17.821  1.000 34.307  0 32  ALA A C     1 ? 
ATOM   276  O  O     . ALA A 1 32  ? 8.330   20.823  17.624  1.000 33.074  0 32  ALA A O     1 ? 
ATOM   277  C  CB    . ALA A 1 32  ? 9.422   18.635  19.974  1.000 31.380  0 32  ALA A CB    1 ? 
ATOM   278  N  N     . VAL A 1 33  ? 8.979   18.760  16.891  1.000 31.116  0 33  VAL A N     1 ? 
ATOM   279  C  CA    . VAL A 1 33  ? 9.375   19.171  15.514  1.000 31.453  0 33  VAL A CA    1 ? 
ATOM   280  C  C     . VAL A 1 33  ? 8.154   19.703  14.762  1.000 31.275  0 33  VAL A C     1 ? 
ATOM   281  O  O     . VAL A 1 33  ? 8.311   20.734  14.076  1.000 31.743  0 33  VAL A O     1 ? 
ATOM   282  C  CB    . VAL A 1 33  ? 10.048  18.031  14.730  1.000 28.802  0 33  VAL A CB    1 ? 
ATOM   283  C  CG1   . VAL A 1 33  ? 10.314  18.403  13.275  1.000 29.520  0 33  VAL A CG1   1 ? 
ATOM   284  C  CG2   . VAL A 1 33  ? 11.344  17.605  15.399  1.000 30.139  0 33  VAL A CG2   1 ? 
ATOM   285  N  N     . LEU A 1 34  ? 7.009   19.024  14.840  1.000 30.698  0 34  LEU A N     1 ? 
ATOM   286  C  CA    . LEU A 1 34  ? 5.814   19.386  14.029  1.000 33.025  0 34  LEU A CA    1 ? 
ATOM   287  C  C     . LEU A 1 34  ? 5.328   20.777  14.464  1.000 33.422  0 34  LEU A C     1 ? 
ATOM   288  O  O     . LEU A 1 34  ? 4.875   21.564  13.597  1.000 32.115  0 34  LEU A O     1 ? 
ATOM   289  C  CB    . LEU A 1 34  ? 4.715   18.329  14.201  1.000 34.518  0 34  LEU A CB    1 ? 
ATOM   290  C  CG    . LEU A 1 34  ? 4.924   16.987  13.490  1.000 35.435  0 34  LEU A CG    1 ? 
ATOM   291  C  CD1   . LEU A 1 34  ? 3.706   16.084  13.682  1.000 34.653  0 34  LEU A CD1   1 ? 
ATOM   292  C  CD2   . LEU A 1 34  ? 5.205   17.170  11.997  1.000 33.823  0 34  LEU A CD2   1 ? 
ATOM   293  N  N     . THR A 1 35  ? 5.433   21.075  15.758  1.000 32.449  0 35  THR A N     1 ? 
ATOM   294  C  CA    . THR A 1 35  ? 5.073   22.394  16.336  1.000 31.938  0 35  THR A CA    1 ? 
ATOM   295  C  C     . THR A 1 35  ? 6.033   23.459  15.806  1.000 30.619  0 35  THR A C     1 ? 
ATOM   296  O  O     . THR A 1 35  ? 5.554   24.517  15.360  1.000 28.593  0 35  THR A O     1 ? 
ATOM   297  C  CB    . THR A 1 35  ? 5.108   22.374  17.863  1.000 30.672  0 35  THR A CB    1 ? 
ATOM   298  O  OG1   . THR A 1 35  ? 4.189   21.372  18.297  1.000 30.492  0 35  THR A OG1   1 ? 
ATOM   299  C  CG2   . THR A 1 35  ? 4.721   23.704  18.470  1.000 32.229  0 35  THR A CG2   1 ? 
ATOM   300  N  N     . ALA A 1 36  ? 7.332   23.195  15.887  1.000 30.118  0 36  ALA A N     1 ? 
ATOM   301  C  CA    . ALA A 1 36  ? 8.380   24.119  15.419  1.000 32.179  0 36  ALA A CA    1 ? 
ATOM   302  C  C     . ALA A 1 36  ? 8.201   24.338  13.906  1.000 34.098  0 36  ALA A C     1 ? 
ATOM   303  O  O     . ALA A 1 36  ? 8.570   25.417  13.416  1.000 38.257  0 36  ALA A O     1 ? 
ATOM   304  C  CB    . ALA A 1 36  ? 9.745   23.612  15.797  1.000 33.006  0 36  ALA A CB    1 ? 
ATOM   305  N  N     . VAL A 1 37  ? 7.573   23.409  13.189  1.000 32.607  0 37  VAL A N     1 ? 
ATOM   306  C  CA    . VAL A 1 37  ? 7.226   23.658  11.765  1.000 32.270  0 37  VAL A CA    1 ? 
ATOM   307  C  C     . VAL A 1 37  ? 6.053   24.655  11.710  1.000 33.734  0 37  VAL A C     1 ? 
ATOM   308  O  O     . VAL A 1 37  ? 6.183   25.628  10.961  1.000 32.237  0 37  VAL A O     1 ? 
ATOM   309  C  CB    . VAL A 1 37  ? 6.938   22.360  10.999  1.000 33.550  0 37  VAL A CB    1 ? 
ATOM   310  C  CG1   . VAL A 1 37  ? 6.513   22.635  9.563   1.000 34.433  0 37  VAL A CG1   1 ? 
ATOM   311  C  CG2   . VAL A 1 37  ? 8.147   21.439  11.022  1.000 34.501  0 37  VAL A CG2   1 ? 
ATOM   312  N  N     . ARG A 1 38  ? 4.969   24.429  12.462  1.000 33.661  0 38  ARG A N     1 ? 
ATOM   313  C  CA    . ARG A 1 38  ? 3.776   25.324  12.463  1.000 36.567  0 38  ARG A CA    1 ? 
ATOM   314  C  C     . ARG A 1 38  ? 4.217   26.734  12.851  1.000 33.608  0 38  ARG A C     1 ? 
ATOM   315  O  O     . ARG A 1 38  ? 3.957   27.654  12.077  1.000 30.993  0 38  ARG A O     1 ? 
ATOM   316  C  CB    . ARG A 1 38  ? 2.697   24.830  13.427  1.000 39.340  0 38  ARG A CB    1 ? 
ATOM   317  C  CG    . ARG A 1 38  ? 1.996   23.567  12.956  1.000 42.220  0 38  ARG A CG    1 ? 
ATOM   318  C  CD    . ARG A 1 38  ? 0.826   23.151  13.822  1.000 45.491  0 38  ARG A CD    1 ? 
ATOM   319  N  NE    . ARG A 1 38  ? 0.513   21.762  13.516  1.000 51.269  0 38  ARG A NE    1 ? 
ATOM   320  C  CZ    . ARG A 1 38  ? 0.964   20.708  14.195  1.000 54.143  0 38  ARG A CZ    1 ? 
ATOM   321  N  NH1   . ARG A 1 38  ? 1.728   20.880  15.263  1.000 54.630  0 38  ARG A NH1   1 ? 
ATOM   322  N  NH2   . ARG A 1 38  ? 0.643   19.482  13.803  1.000 50.515  0 38  ARG A NH2   1 ? 
ATOM   323  N  N     . GLU A 1 39  ? 4.874   26.865  14.001  1.000 33.888  0 39  GLU A N     1 ? 
ATOM   324  C  CA    . GLU A 1 39  ? 5.445   28.147  14.496  1.000 37.048  0 39  GLU A CA    1 ? 
ATOM   325  C  C     . GLU A 1 39  ? 6.285   28.792  13.384  1.000 38.772  0 39  GLU A C     1 ? 
ATOM   326  O  O     . GLU A 1 39  ? 6.125   30.004  13.141  1.000 37.916  0 39  GLU A O     1 ? 
ATOM   327  C  CB    . GLU A 1 39  ? 6.334   27.962  15.722  1.000 38.151  0 39  GLU A CB    1 ? 
ATOM   328  C  CG    . GLU A 1 39  ? 5.737   27.179  16.887  1.000 44.024  0 39  GLU A CG    1 ? 
ATOM   329  C  CD    . GLU A 1 39  ? 4.287   27.437  17.263  1.000 52.361  0 39  GLU A CD    1 ? 
ATOM   330  O  OE1   . GLU A 1 39  ? 3.720   26.588  17.992  1.000 55.751  0 39  GLU A OE1   1 ? 
ATOM   331  O  OE2   . GLU A 1 39  ? 3.722   28.487  16.854  1.000 56.517  0 39  GLU A OE2   1 ? 
ATOM   332  N  N     . GLY A 1 40  ? 7.163   28.017  12.750  1.000 36.804  0 40  GLY A N     1 ? 
ATOM   333  C  CA    . GLY A 1 40  ? 8.155   28.539  11.794  1.000 38.762  0 40  GLY A CA    1 ? 
ATOM   334  C  C     . GLY A 1 40  ? 7.491   29.036  10.519  1.000 40.128  0 40  GLY A C     1 ? 
ATOM   335  O  O     . GLY A 1 40  ? 7.983   30.026  9.924   1.000 35.323  0 40  GLY A O     1 ? 
ATOM   336  N  N     . LEU A 1 41  ? 6.421   28.376  10.088  1.000 37.793  0 41  LEU A N     1 ? 
ATOM   337  C  CA    . LEU A 1 41  ? 5.712   28.745  8.834   1.000 39.894  0 41  LEU A CA    1 ? 
ATOM   338  C  C     . LEU A 1 41  ? 4.997   30.095  9.017   1.000 38.197  0 41  LEU A C     1 ? 
ATOM   339  O  O     . LEU A 1 41  ? 4.998   30.900  8.059   1.000 34.739  0 41  LEU A O     1 ? 
ATOM   340  C  CB    . LEU A 1 41  ? 4.738   27.635  8.441   1.000 35.947  0 41  LEU A CB    1 ? 
ATOM   341  C  CG    . LEU A 1 41  ? 5.354   26.458  7.680   1.000 38.079  0 41  LEU A CG    1 ? 
ATOM   342  C  CD1   . LEU A 1 41  ? 4.317   25.355  7.459   1.000 36.180  0 41  LEU A CD1   1 ? 
ATOM   343  C  CD2   . LEU A 1 41  ? 5.945   26.901  6.340   1.000 38.774  0 41  LEU A CD2   1 ? 
ATOM   344  N  N     . LYS A 1 42  ? 4.416   30.334  10.192  1.000 35.787  0 42  LYS A N     1 ? 
ATOM   345  C  CA    . LYS A 1 42  ? 3.807   31.642  10.543  1.000 39.561  0 42  LYS A CA    1 ? 
ATOM   346  C  C     . LYS A 1 42  ? 4.850   32.745  10.310  1.000 40.300  0 42  LYS A C     1 ? 
ATOM   347  O  O     . LYS A 1 42  ? 4.557   33.677  9.543   1.000 43.300  0 42  LYS A O     1 ? 
ATOM   348  C  CB    . LYS A 1 42  ? 3.297   31.631  11.987  1.000 43.123  0 42  LYS A CB    1 ? 
ATOM   349  C  CG    . LYS A 1 42  ? 2.284   30.535  12.293  1.000 49.022  0 42  LYS A CG    1 ? 
ATOM   350  C  CD    . LYS A 1 42  ? 1.338   30.850  13.447  1.000 53.124  0 42  LYS A CD    1 ? 
ATOM   351  C  CE    . LYS A 1 42  ? 0.076   30.005  13.442  1.000 54.014  0 42  LYS A CE    1 ? 
ATOM   352  N  NZ    . LYS A 1 42  ? -0.848  30.390  14.542  1.000 58.540  0 42  LYS A NZ    1 ? 
ATOM   353  N  N     . LYS A 1 43  ? 6.041   32.605  10.904  1.000 41.520  0 43  LYS A N     1 ? 
ATOM   354  C  CA    . LYS A 1 43  ? 7.146   33.600  10.823  1.000 45.464  0 43  LYS A CA    1 ? 
ATOM   355  C  C     . LYS A 1 43  ? 7.542   33.781  9.351   1.000 41.452  0 43  LYS A C     1 ? 
ATOM   356  O  O     . LYS A 1 43  ? 7.630   34.962  8.878   1.000 40.794  0 43  LYS A O     1 ? 
ATOM   357  C  CB    . LYS A 1 43  ? 8.305   33.164  11.729  1.000 52.611  0 43  LYS A CB    1 ? 
ATOM   358  C  CG    . LYS A 1 43  ? 9.614   33.945  11.596  1.000 62.775  0 43  LYS A CG    1 ? 
ATOM   359  C  CD    . LYS A 1 43  ? 10.677  33.285  10.696  1.000 70.343  0 43  LYS A CD    1 ? 
ATOM   360  C  CE    . LYS A 1 43  ? 11.044  31.851  11.064  1.000 73.087  0 43  LYS A CE    1 ? 
ATOM   361  N  NZ    . LYS A 1 43  ? 11.625  31.733  12.426  1.000 75.135  0 43  LYS A NZ    1 ? 
ATOM   362  N  N     . VAL A 1 44  ? 7.737   32.677  8.632   1.000 35.413  0 44  VAL A N     1 ? 
ATOM   363  C  CA    . VAL A 1 44  ? 8.224   32.700  7.223   1.000 34.958  0 44  VAL A CA    1 ? 
ATOM   364  C  C     . VAL A 1 44  ? 7.200   33.439  6.362   1.000 34.953  0 44  VAL A C     1 ? 
ATOM   365  O  O     . VAL A 1 44  ? 7.595   34.362  5.626   1.000 33.442  0 44  VAL A O     1 ? 
ATOM   366  C  CB    . VAL A 1 44  ? 8.487   31.289  6.659   1.000 36.437  0 44  VAL A CB    1 ? 
ATOM   367  C  CG1   . VAL A 1 44  ? 8.638   31.317  5.144   1.000 36.455  0 44  VAL A CG1   1 ? 
ATOM   368  C  CG2   . VAL A 1 44  ? 9.710   30.642  7.300   1.000 39.307  0 44  VAL A CG2   1 ? 
ATOM   369  N  N     . PHE A 1 45  ? 5.942   33.011  6.412   1.000 32.560  0 45  PHE A N     1 ? 
ATOM   370  C  CA    . PHE A 1 45  ? 4.894   33.494  5.480   1.000 33.903  0 45  PHE A CA    1 ? 
ATOM   371  C  C     . PHE A 1 45  ? 4.474   34.923  5.859   1.000 35.771  0 45  PHE A C     1 ? 
ATOM   372  O  O     . PHE A 1 45  ? 4.288   35.705  4.919   1.000 36.360  0 45  PHE A O     1 ? 
ATOM   373  C  CB    . PHE A 1 45  ? 3.762   32.474  5.362   1.000 28.764  0 45  PHE A CB    1 ? 
ATOM   374  C  CG    . PHE A 1 45  ? 4.099   31.433  4.338   1.000 27.458  0 45  PHE A CG    1 ? 
ATOM   375  C  CD1   . PHE A 1 45  ? 4.949   30.386  4.654   1.000 27.739  0 45  PHE A CD1   1 ? 
ATOM   376  C  CD2   . PHE A 1 45  ? 3.686   31.583  3.021   1.000 27.379  0 45  PHE A CD2   1 ? 
ATOM   377  C  CE1   . PHE A 1 45  ? 5.333   29.474  3.682   1.000 27.882  0 45  PHE A CE1   1 ? 
ATOM   378  C  CE2   . PHE A 1 45  ? 4.068   30.673  2.051   1.000 27.411  0 45  PHE A CE2   1 ? 
ATOM   379  C  CZ    . PHE A 1 45  ? 4.893   29.619  2.384   1.000 27.537  0 45  PHE A CZ    1 ? 
ATOM   380  N  N     . ALA A 1 46  ? 4.386   35.266  7.154   1.000 34.316  0 46  ALA A N     1 ? 
ATOM   381  C  CA    . ALA A 1 46  ? 4.063   36.639  7.613   1.000 35.553  0 46  ALA A CA    1 ? 
ATOM   382  C  C     . ALA A 1 46  ? 5.140   37.597  7.096   1.000 37.997  0 46  ALA A C     1 ? 
ATOM   383  O  O     . ALA A 1 46  ? 4.790   38.688  6.618   1.000 40.163  0 46  ALA A O     1 ? 
ATOM   384  C  CB    . ALA A 1 46  ? 3.963   36.700  9.113   1.000 37.307  0 46  ALA A CB    1 ? 
ATOM   385  N  N     . ASP A 1 47  ? 6.400   37.170  7.187   1.000 38.294  0 47  ASP A N     1 ? 
ATOM   386  C  CA    . ASP A 1 47  ? 7.574   37.817  6.562   1.000 39.820  0 47  ASP A CA    1 ? 
ATOM   387  C  C     . ASP A 1 47  ? 7.272   38.130  5.095   1.000 40.036  0 47  ASP A C     1 ? 
ATOM   388  O  O     . ASP A 1 47  ? 7.673   39.209  4.625   1.000 42.221  0 47  ASP A O     1 ? 
ATOM   389  C  CB    . ASP A 1 47  ? 8.791   36.910  6.673   1.000 45.203  0 47  ASP A CB    1 ? 
ATOM   390  C  CG    . ASP A 1 47  ? 10.081  37.683  6.821   1.000 51.849  0 47  ASP A CG    1 ? 
ATOM   391  O  OD1   . ASP A 1 47  ? 10.929  37.260  7.653   1.000 53.446  0 47  ASP A OD1   1 ? 
ATOM   392  O  OD2   . ASP A 1 47  ? 10.207  38.722  6.140   1.000 54.631  0 47  ASP A OD2   1 ? 
ATOM   393  N  N     . ARG A 1 48  ? 6.581   37.227  4.403   1.000 37.985  0 48  ARG A N     1 ? 
ATOM   394  C  CA    . ARG A 1 48  ? 6.261   37.384  2.962   1.000 40.056  0 48  ARG A CA    1 ? 
ATOM   395  C  C     . ARG A 1 48  ? 4.876   37.992  2.784   1.000 37.870  0 48  ARG A C     1 ? 
ATOM   396  O  O     . ARG A 1 48  ? 4.422   38.021  1.641   1.000 39.391  0 48  ARG A O     1 ? 
ATOM   397  C  CB    . ARG A 1 48  ? 6.342   36.033  2.263   1.000 41.124  0 48  ARG A CB    1 ? 
ATOM   398  C  CG    . ARG A 1 48  ? 7.706   35.386  2.410   1.000 45.795  0 48  ARG A CG    1 ? 
ATOM   399  C  CD    . ARG A 1 48  ? 7.625   33.883  2.378   1.000 49.013  0 48  ARG A CD    1 ? 
ATOM   400  N  NE    . ARG A 1 48  ? 7.044   33.382  1.140   1.000 53.134  0 48  ARG A NE    1 ? 
ATOM   401  C  CZ    . ARG A 1 48  ? 7.393   32.236  0.553   1.000 55.845  0 48  ARG A CZ    1 ? 
ATOM   402  N  NH1   . ARG A 1 48  ? 6.799   31.860  -0.570  1.000 56.867  0 48  ARG A NH1   1 ? 
ATOM   403  N  NH2   . ARG A 1 48  ? 8.339   31.477  1.086   1.000 52.674  0 48  ARG A NH2   1 ? 
ATOM   404  N  N     . GLY A 1 49  ? 4.228   38.436  3.864   1.000 34.355  0 49  GLY A N     1 ? 
ATOM   405  C  CA    . GLY A 1 49  ? 2.858   38.985  3.814   1.000 34.498  0 49  GLY A CA    1 ? 
ATOM   406  C  C     . GLY A 1 49  ? 1.869   38.066  3.107   1.000 35.295  0 49  GLY A C     1 ? 
ATOM   407  O  O     . GLY A 1 49  ? 1.058   38.571  2.308   1.000 36.694  0 49  GLY A O     1 ? 
ATOM   408  N  N     . GLU A 1 50  ? 1.893   36.759  3.397   1.000 37.277  0 50  GLU A N     1 ? 
ATOM   409  C  CA    . GLU A 1 50  ? 0.823   35.798  2.988   1.000 35.548  0 50  GLU A CA    1 ? 
ATOM   410  C  C     . GLU A 1 50  ? 0.413   34.986  4.213   1.000 34.539  0 50  GLU A C     1 ? 
ATOM   411  O  O     . GLU A 1 50  ? 1.148   35.032  5.218   1.000 32.258  0 50  GLU A O     1 ? 
ATOM   412  C  CB    . GLU A 1 50  ? 1.294   34.806  1.920   1.000 37.890  0 50  GLU A CB    1 ? 
ATOM   413  C  CG    . GLU A 1 50  ? 1.468   35.387  0.534   1.000 38.498  0 50  GLU A CG    1 ? 
ATOM   414  C  CD    . GLU A 1 50  ? 2.645   34.815  -0.245  1.000 42.303  0 50  GLU A CD    1 ? 
ATOM   415  O  OE1   . GLU A 1 50  ? 3.081   33.680  0.053   1.000 42.246  0 50  GLU A OE1   1 ? 
ATOM   416  O  OE2   . GLU A 1 50  ? 3.137   35.514  -1.148  1.000 53.001  0 50  GLU A OE2   1 ? 
ATOM   417  N  N     . ALA A 1 51  ? -0.678  34.223  4.121   1.000 33.676  0 51  ALA A N     1 ? 
ATOM   418  C  CA    . ALA A 1 51  ? -1.039  33.210  5.145   1.000 32.376  0 51  ALA A CA    1 ? 
ATOM   419  C  C     . ALA A 1 51  ? -0.142  31.980  4.960   1.000 32.443  0 51  ALA A C     1 ? 
ATOM   420  O  O     . ALA A 1 51  ? 0.243   31.661  3.817   1.000 29.379  0 51  ALA A O     1 ? 
ATOM   421  C  CB    . ALA A 1 51  ? -2.498  32.848  5.061   1.000 33.156  0 51  ALA A CB    1 ? 
ATOM   422  N  N     . ALA A 1 52  ? 0.201   31.337  6.070   1.000 36.358  0 52  ALA A N     1 ? 
ATOM   423  C  CA    . ALA A 1 52  ? 0.969   30.076  6.120   1.000 34.802  0 52  ALA A CA    1 ? 
ATOM   424  C  C     . ALA A 1 52  ? 0.126   28.961  5.521   1.000 31.233  0 52  ALA A C     1 ? 
ATOM   425  O  O     . ALA A 1 52  ? -1.063  28.895  5.773   1.000 32.398  0 52  ALA A O     1 ? 
ATOM   426  C  CB    . ALA A 1 52  ? 1.345   29.760  7.544   1.000 36.545  0 52  ALA A CB    1 ? 
ATOM   427  N  N     . PRO A 1 53  ? 0.709   28.054  4.710   1.000 32.059  0 53  PRO A N     1 ? 
ATOM   428  C  CA    . PRO A 1 53  ? 0.024   26.821  4.342   1.000 32.684  0 53  PRO A CA    1 ? 
ATOM   429  C  C     . PRO A 1 53  ? -0.111  25.948  5.588   1.000 30.360  0 53  PRO A C     1 ? 
ATOM   430  O  O     . PRO A 1 53  ? 0.705   26.082  6.494   1.000 31.203  0 53  PRO A O     1 ? 
ATOM   431  C  CB    . PRO A 1 53  ? 0.954   26.141  3.329   1.000 32.934  0 53  PRO A CB    1 ? 
ATOM   432  C  CG    . PRO A 1 53  ? 2.323   26.691  3.686   1.000 33.187  0 53  PRO A CG    1 ? 
ATOM   433  C  CD    . PRO A 1 53  ? 2.079   28.106  4.183   1.000 34.423  0 53  PRO A CD    1 ? 
ATOM   434  N  N     . THR A 1 54  ? -1.131  25.104  5.610   1.000 30.138  0 54  THR A N     1 ? 
ATOM   435  C  CA    . THR A 1 54  ? -1.381  24.139  6.701   1.000 28.277  0 54  THR A CA    1 ? 
ATOM   436  C  C     . THR A 1 54  ? -0.866  22.775  6.230   1.000 28.547  0 54  THR A C     1 ? 
ATOM   437  O  O     . THR A 1 54  ? -0.585  22.595  5.022   1.000 25.181  0 54  THR A O     1 ? 
ATOM   438  C  CB    . THR A 1 54  ? -2.871  24.099  7.069   1.000 29.425  0 54  THR A CB    1 ? 
ATOM   439  O  OG1   . THR A 1 54  ? -3.618  23.998  5.855   1.000 26.745  0 54  THR A OG1   1 ? 
ATOM   440  C  CG2   . THR A 1 54  ? -3.333  25.309  7.854   1.000 30.156  0 54  THR A CG2   1 ? 
ATOM   441  N  N     . PHE A 1 55  ? -0.810  21.814  7.131   1.000 28.276  0 55  PHE A N     1 ? 
ATOM   442  C  CA    . PHE A 1 55  ? -0.335  20.463  6.785   1.000 29.634  0 55  PHE A CA    1 ? 
ATOM   443  C  C     . PHE A 1 55  ? -0.946  19.455  7.736   1.000 30.415  0 55  PHE A C     1 ? 
ATOM   444  O  O     . PHE A 1 55  ? -1.219  19.811  8.890   1.000 28.927  0 55  PHE A O     1 ? 
ATOM   445  C  CB    . PHE A 1 55  ? 1.191   20.408  6.822   1.000 30.027  0 55  PHE A CB    1 ? 
ATOM   446  C  CG    . PHE A 1 55  ? 1.812   20.532  8.193   1.000 31.315  0 55  PHE A CG    1 ? 
ATOM   447  C  CD1   . PHE A 1 55  ? 1.946   19.420  9.017   1.000 30.545  0 55  PHE A CD1   1 ? 
ATOM   448  C  CD2   . PHE A 1 55  ? 2.283   21.759  8.655   1.000 32.983  0 55  PHE A CD2   1 ? 
ATOM   449  C  CE1   . PHE A 1 55  ? 2.515   19.540  10.275  1.000 33.502  0 55  PHE A CE1   1 ? 
ATOM   450  C  CE2   . PHE A 1 55  ? 2.880   21.869  9.905   1.000 31.413  0 55  PHE A CE2   1 ? 
ATOM   451  C  CZ    . PHE A 1 55  ? 2.996   20.761  10.711  1.000 32.232  0 55  PHE A CZ    1 ? 
ATOM   452  N  N     . THR A 1 56  ? -1.137  18.248  7.220   1.000 30.520  0 56  THR A N     1 ? 
ATOM   453  C  CA    . THR A 1 56  ? -1.511  17.035  7.971   1.000 31.877  0 56  THR A CA    1 ? 
ATOM   454  C  C     . THR A 1 56  ? -0.258  16.175  8.112   1.000 29.929  0 56  THR A C     1 ? 
ATOM   455  O  O     . THR A 1 56  ? 0.336   15.778  7.116   1.000 32.098  0 56  THR A O     1 ? 
ATOM   456  C  CB    . THR A 1 56  ? -2.640  16.305  7.243   1.000 34.110  0 56  THR A CB    1 ? 
ATOM   457  O  OG1   . THR A 1 56  ? -3.716  17.233  7.082   1.000 36.902  0 56  THR A OG1   1 ? 
ATOM   458  C  CG2   . THR A 1 56  ? -3.134  15.084  7.986   1.000 36.759  0 56  THR A CG2   1 ? 
ATOM   459  N  N     . PRO A 1 57  ? 0.196   15.869  9.341   1.000 25.849  0 57  PRO A N     1 ? 
ATOM   460  C  CA    . PRO A 1 57  ? 1.290   14.928  9.532   1.000 24.291  0 57  PRO A CA    1 ? 
ATOM   461  C  C     . PRO A 1 57  ? 0.765   13.488  9.581   1.000 25.743  0 57  PRO A C     1 ? 
ATOM   462  O  O     . PRO A 1 57  ? -0.385  13.275  9.936   1.000 24.895  0 57  PRO A O     1 ? 
ATOM   463  C  CB    . PRO A 1 57  ? 1.806   15.344  10.900  1.000 24.700  0 57  PRO A CB    1 ? 
ATOM   464  C  CG    . PRO A 1 57  ? 0.529   15.673  11.652  1.000 26.213  0 57  PRO A CG    1 ? 
ATOM   465  C  CD    . PRO A 1 57  ? -0.351  16.352  10.616  1.000 27.287  0 57  PRO A CD    1 ? 
ATOM   466  N  N     . PHE A 1 58  ? 1.623   12.532  9.252   1.000 21.696  0 58  PHE A N     1 ? 
ATOM   467  C  CA    . PHE A 1 58  ? 1.322   11.094  9.376   1.000 20.390  0 58  PHE A CA    1 ? 
ATOM   468  C  C     . PHE A 1 58  ? 2.616   10.358  9.667   1.000 19.102  0 58  PHE A C     1 ? 
ATOM   469  O  O     . PHE A 1 58  ? 3.677   10.747  9.156   1.000 16.840  0 58  PHE A O     1 ? 
ATOM   470  C  CB    . PHE A 1 58  ? 0.590   10.564  8.140   1.000 20.928  0 58  PHE A CB    1 ? 
ATOM   471  C  CG    . PHE A 1 58  ? 1.352   10.575  6.837   1.000 20.232  0 58  PHE A CG    1 ? 
ATOM   472  C  CD1   . PHE A 1 58  ? 1.323   11.688  6.013   1.000 20.956  0 58  PHE A CD1   1 ? 
ATOM   473  C  CD2   . PHE A 1 58  ? 2.004   9.430   6.381   1.000 19.502  0 58  PHE A CD2   1 ? 
ATOM   474  C  CE1   . PHE A 1 58  ? 1.993   11.683  4.799   1.000 20.985  0 58  PHE A CE1   1 ? 
ATOM   475  C  CE2   . PHE A 1 58  ? 2.691   9.436   5.178   1.000 18.684  0 58  PHE A CE2   1 ? 
ATOM   476  C  CZ    . PHE A 1 58  ? 2.653   10.547  4.372   1.000 20.075  0 58  PHE A CZ    1 ? 
ATOM   477  N  N     . ASN A 1 59  ? 2.531   9.358   10.536  1.000 19.995  0 59  ASN A N     1 ? 
ATOM   478  C  CA    . ASN A 1 59  ? 3.679   8.478   10.875  1.000 19.817  0 59  ASN A CA    1 ? 
ATOM   479  C  C     . ASN A 1 59  ? 4.151   7.728   9.627   1.000 19.341  0 59  ASN A C     1 ? 
ATOM   480  O  O     . ASN A 1 59  ? 3.303   7.242   8.851   1.000 19.127  0 59  ASN A O     1 ? 
ATOM   481  C  CB    . ASN A 1 59  ? 3.300   7.528   12.007  1.000 20.874  0 59  ASN A CB    1 ? 
ATOM   482  C  CG    . ASN A 1 59  ? 2.983   8.263   13.291  1.000 22.236  0 59  ASN A CG    1 ? 
ATOM   483  O  OD1   . ASN A 1 59  ? 3.406   9.411   13.490  1.000 23.768  0 59  ASN A OD1   1 ? 
ATOM   484  N  ND2   . ASN A 1 59  ? 2.284   7.597   14.187  1.000 23.678  0 59  ASN A ND2   1 ? 
ATOM   485  N  N     . GLN A 1 60  ? 5.461   7.618   9.476   1.000 20.024  0 60  GLN A N     1 ? 
ATOM   486  C  CA    . GLN A 1 60  ? 6.138   6.891   8.382   1.000 21.158  0 60  GLN A CA    1 ? 
ATOM   487  C  C     . GLN A 1 60  ? 7.256   6.023   8.947   1.000 18.738  0 60  GLN A C     1 ? 
ATOM   488  O  O     . GLN A 1 60  ? 7.682   6.237   10.085  1.000 16.245  0 60  GLN A O     1 ? 
ATOM   489  C  CB    . GLN A 1 60  ? 6.792   7.872   7.407   1.000 23.664  0 60  GLN A CB    1 ? 
ATOM   490  C  CG    . GLN A 1 60  ? 5.921   8.169   6.212   1.000 27.306  0 60  GLN A CG    1 ? 
ATOM   491  C  CD    . GLN A 1 60  ? 6.666   9.038   5.242   1.000 27.151  0 60  GLN A CD    1 ? 
ATOM   492  O  OE1   . GLN A 1 60  ? 7.825   8.788   4.920   1.000 34.103  0 60  GLN A OE1   1 ? 
ATOM   493  N  NE2   . GLN A 1 60  ? 6.001   10.065  4.775   1.000 28.214  0 60  GLN A NE2   1 ? 
ATOM   494  N  N     . GLY A 1 61  ? 7.802   5.169   8.086   1.000 17.341  0 61  GLY A N     1 ? 
ATOM   495  C  CA    . GLY A 1 61  ? 8.990   4.369   8.406   1.000 16.130  0 61  GLY A CA    1 ? 
ATOM   496  C  C     . GLY A 1 61  ? 8.759   3.369   9.519   1.000 14.995  0 61  GLY A C     1 ? 
ATOM   497  O  O     . GLY A 1 61  ? 7.595   3.039   9.869   1.000 12.449  0 61  GLY A O     1 ? 
ATOM   498  N  N     . SER A 1 62  ? 9.864   2.826   9.983   1.000 15.620  0 62  SER A N     1 ? 
ATOM   499  C  CA    . SER A 1 62  ? 9.919   1.598   10.792  1.000 16.981  0 62  SER A CA    1 ? 
ATOM   500  C  C     . SER A 1 62  ? 9.226   1.869   12.120  1.000 17.184  0 62  SER A C     1 ? 
ATOM   501  O  O     . SER A 1 62  ? 8.647   0.914   12.709  1.000 17.987  0 62  SER A O     1 ? 
ATOM   502  C  CB    . SER A 1 62  ? 11.342  1.176   10.958  1.000 18.830  0 62  SER A CB    1 ? 
ATOM   503  O  OG    . SER A 1 62  ? 12.054  2.146   11.688  1.000 19.184  0 62  SER A OG    1 ? 
ATOM   504  N  N     . TYR A 1 63  ? 9.211   3.137   12.543  1.000 18.429  0 63  TYR A N     1 ? 
ATOM   505  C  CA    . TYR A 1 63  ? 8.540   3.534   13.807  1.000 20.078  0 63  TYR A CA    1 ? 
ATOM   506  C  C     . TYR A 1 63  ? 7.023   3.433   13.621  1.000 19.133  0 63  TYR A C     1 ? 
ATOM   507  O  O     . TYR A 1 63  ? 6.312   3.206   14.623  1.000 21.307  0 63  TYR A O     1 ? 
ATOM   508  C  CB    . TYR A 1 63  ? 9.077   4.874   14.310  1.000 20.826  0 63  TYR A CB    1 ? 
ATOM   509  C  CG    . TYR A 1 63  ? 10.578  4.913   14.513  1.000 22.161  0 63  TYR A CG    1 ? 
ATOM   510  C  CD1   . TYR A 1 63  ? 11.379  3.795   14.337  1.000 24.574  0 63  TYR A CD1   1 ? 
ATOM   511  C  CD2   . TYR A 1 63  ? 11.204  6.076   14.932  1.000 26.228  0 63  TYR A CD2   1 ? 
ATOM   512  C  CE1   . TYR A 1 63  ? 12.745  3.828   14.562  1.000 24.924  0 63  TYR A CE1   1 ? 
ATOM   513  C  CE2   . TYR A 1 63  ? 12.575  6.139   15.138  1.000 27.337  0 63  TYR A CE2   1 ? 
ATOM   514  C  CZ    . TYR A 1 63  ? 13.355  5.012   14.947  1.000 28.374  0 63  TYR A CZ    1 ? 
ATOM   515  O  OH    . TYR A 1 63  ? 14.715  5.082   15.127  1.000 29.210  0 63  TYR A OH    1 ? 
ATOM   516  N  N     . ALA A 1 64  ? 6.531   3.552   12.394  1.000 18.502  0 64  ALA A N     1 ? 
ATOM   517  C  CA    . ALA A 1 64  ? 5.096   3.424   12.080  1.000 20.503  0 64  ALA A CA    1 ? 
ATOM   518  C  C     . ALA A 1 64  ? 4.752   1.963   11.804  1.000 19.723  0 64  ALA A C     1 ? 
ATOM   519  O  O     . ALA A 1 64  ? 3.579   1.617   11.930  1.000 19.079  0 64  ALA A O     1 ? 
ATOM   520  C  CB    . ALA A 1 64  ? 4.724   4.309   10.919  1.000 20.154  0 64  ALA A CB    1 ? 
ATOM   521  N  N     . MET A 1 65  ? 5.744   1.135   11.476  1.000 19.906  0 65  MET A N     1 ? 
ATOM   522  C  CA    . MET A 1 65  ? 5.545   -0.234  10.938  1.000 19.117  0 65  MET A CA    1 ? 
ATOM   523  C  C     . MET A 1 65  ? 5.914   -1.270  12.000  1.000 18.231  0 65  MET A C     1 ? 
ATOM   524  O  O     . MET A 1 65  ? 5.799   -2.470  11.706  1.000 17.297  0 65  MET A O     1 ? 
ATOM   525  C  CB    . MET A 1 65  ? 6.408   -0.480  9.686   1.000 18.465  0 65  MET A CB    1 ? 
ATOM   526  C  CG    . MET A 1 65  ? 5.835   0.193   8.475   1.000 17.601  0 65  MET A CG    1 ? 
ATOM   527  S  SD    . MET A 1 65  ? 6.688   -0.133  6.977   1.000 18.403  0 65  MET A SD    1 ? 
ATOM   528  C  CE    . MET A 1 65  ? 8.139   0.902   7.202   1.000 18.884  0 65  MET A CE    1 ? 
ATOM   529  N  N     . ASN A 1 66  ? 6.399   -0.827  13.156  1.000 17.675  0 66  ASN A N     1 ? 
ATOM   530  C  CA    . ASN A 1 66  ? 6.839   -1.743  14.238  1.000 18.567  0 66  ASN A CA    1 ? 
ATOM   531  C  C     . ASN A 1 66  ? 8.016   -2.602  13.742  1.000 17.188  0 66  ASN A C     1 ? 
ATOM   532  O  O     . ASN A 1 66  ? 8.052   -3.815  14.009  1.000 16.788  0 66  ASN A O     1 ? 
ATOM   533  C  CB    . ASN A 1 66  ? 5.668   -2.596  14.727  1.000 18.813  0 66  ASN A CB    1 ? 
ATOM   534  C  CG    . ASN A 1 66  ? 5.877   -3.154  16.116  1.000 19.345  0 66  ASN A CG    1 ? 
ATOM   535  O  OD1   . ASN A 1 66  ? 6.694   -2.660  16.903  1.000 19.508  0 66  ASN A OD1   1 ? 
ATOM   536  N  ND2   . ASN A 1 66  ? 5.091   -4.163  16.448  1.000 22.195  0 66  ASN A ND2   1 ? 
ATOM   537  N  N     . THR A 1 67  ? 8.955   -1.996  13.036  1.000 15.776  0 67  THR A N     1 ? 
ATOM   538  C  CA    . THR A 1 67  ? 10.197  -2.690  12.633  1.000 15.900  0 67  THR A CA    1 ? 
ATOM   539  C  C     . THR A 1 67  ? 11.401  -1.835  13.009  1.000 16.591  0 67  THR A C     1 ? 
ATOM   540  O  O     . THR A 1 67  ? 12.414  -1.971  12.340  1.000 17.354  0 67  THR A O     1 ? 
ATOM   541  C  CB    . THR A 1 67  ? 10.197  -2.973  11.135  1.000 15.402  0 67  THR A CB    1 ? 
ATOM   542  O  OG1   . THR A 1 67  ? 9.967   -1.699  10.550  1.000 14.585  0 67  THR A OG1   1 ? 
ATOM   543  C  CG2   . THR A 1 67  ? 9.153   -3.995  10.730  1.000 15.881  0 67  THR A CG2   1 ? 
ATOM   544  N  N     . GLY A 1 68  ? 11.263  -0.995  14.037  1.000 16.582  0 68  GLY A N     1 ? 
ATOM   545  C  CA    . GLY A 1 68  ? 12.323  -0.115  14.539  1.000 16.647  0 68  GLY A CA    1 ? 
ATOM   546  C  C     . GLY A 1 68  ? 13.293  -0.851  15.440  1.000 16.677  0 68  GLY A C     1 ? 
ATOM   547  O  O     . GLY A 1 68  ? 12.860  -1.735  16.206  1.000 14.491  0 68  GLY A O     1 ? 
ATOM   548  N  N     . VAL A 1 69  ? 14.569  -0.471  15.385  1.000 18.041  0 69  VAL A N     1 ? 
ATOM   549  C  CA    . VAL A 1 69  ? 15.581  -0.973  16.358  1.000 18.407  0 69  VAL A CA    1 ? 
ATOM   550  C  C     . VAL A 1 69  ? 16.290  0.219   16.969  1.000 16.973  0 69  VAL A C     1 ? 
ATOM   551  O  O     . VAL A 1 69  ? 16.306  1.309   16.343  1.000 14.252  0 69  VAL A O     1 ? 
ATOM   552  C  CB    . VAL A 1 69  ? 16.597  -1.943  15.744  1.000 19.411  0 69  VAL A CB    1 ? 
ATOM   553  C  CG1   . VAL A 1 69  ? 15.909  -3.177  15.189  1.000 21.467  0 69  VAL A CG1   1 ? 
ATOM   554  C  CG2   . VAL A 1 69  ? 17.446  -1.259  14.693  1.000 20.495  0 69  VAL A CG2   1 ? 
ATOM   555  N  N     . LYS A 1 70  ? 16.836  -0.028  18.158  1.000 16.622  0 70  LYS A N     1 ? 
ATOM   556  C  CA    . LYS A 1 70  ? 17.718  0.895   18.896  1.000 17.286  0 70  LYS A CA    1 ? 
ATOM   557  C  C     . LYS A 1 70  ? 19.043  1.001   18.135  1.000 18.036  0 70  LYS A C     1 ? 
ATOM   558  O  O     . LYS A 1 70  ? 19.594  -0.001  17.674  1.000 17.247  0 70  LYS A O     1 ? 
ATOM   559  C  CB    . LYS A 1 70  ? 17.892  0.363   20.314  1.000 16.930  0 70  LYS A CB    1 ? 
ATOM   560  C  CG    . LYS A 1 70  ? 16.651  0.431   21.184  1.000 17.484  0 70  LYS A CG    1 ? 
ATOM   561  C  CD    . LYS A 1 70  ? 16.893  -0.180  22.576  1.000 18.108  0 70  LYS A CD    1 ? 
ATOM   562  C  CE    . LYS A 1 70  ? 15.710  -0.030  23.522  1.000 18.092  0 70  LYS A CE    1 ? 
ATOM   563  N  NZ    . LYS A 1 70  ? 15.847  -0.889  24.725  1.000 17.683  0 70  LYS A NZ    1 ? 
ATOM   564  N  N     . PRO A 1 71  ? 19.586  2.222   17.976  1.000 20.623  0 71  PRO A N     1 ? 
ATOM   565  C  CA    . PRO A 1 71  ? 20.916  2.393   17.412  1.000 22.766  0 71  PRO A CA    1 ? 
ATOM   566  C  C     . PRO A 1 71  ? 21.988  1.792   18.324  1.000 23.494  0 71  PRO A C     1 ? 
ATOM   567  O  O     . PRO A 1 71  ? 21.743  1.660   19.476  1.000 22.505  0 71  PRO A O     1 ? 
ATOM   568  C  CB    . PRO A 1 71  ? 21.089  3.919   17.334  1.000 24.264  0 71  PRO A CB    1 ? 
ATOM   569  C  CG    . PRO A 1 71  ? 20.172  4.467   18.398  1.000 21.925  0 71  PRO A CG    1 ? 
ATOM   570  C  CD    . PRO A 1 71  ? 19.022  3.495   18.462  1.000 22.055  0 71  PRO A CD    1 ? 
ATOM   571  N  N     . LEU A 1 72  ? 23.148  1.449   17.781  1.000 24.682  0 72  LEU A N     1 ? 
ATOM   572  C  CA    . LEU A 1 72  ? 24.337  1.148   18.614  1.000 26.063  0 72  LEU A CA    1 ? 
ATOM   573  C  C     . LEU A 1 72  ? 24.897  2.472   19.154  1.000 28.878  0 72  LEU A C     1 ? 
ATOM   574  O  O     . LEU A 1 72  ? 24.488  3.529   18.656  1.000 26.409  0 72  LEU A O     1 ? 
ATOM   575  C  CB    . LEU A 1 72  ? 25.341  0.378   17.773  1.000 25.358  0 72  LEU A CB    1 ? 
ATOM   576  C  CG    . LEU A 1 72  ? 24.810  -0.930  17.195  1.000 25.705  0 72  LEU A CG    1 ? 
ATOM   577  C  CD1   . LEU A 1 72  ? 25.753  -1.455  16.117  1.000 26.420  0 72  LEU A CD1   1 ? 
ATOM   578  C  CD2   . LEU A 1 72  ? 24.600  -1.972  18.279  1.000 24.226  0 72  LEU A CD2   1 ? 
ATOM   579  N  N     . GLU A 1 73  ? 25.720  2.412   20.205  1.000 32.389  0 73  GLU A N     1 ? 
ATOM   580  C  CA    . GLU A 1 73  ? 26.334  3.599   20.854  1.000 33.156  0 73  GLU A CA    1 ? 
ATOM   581  C  C     . GLU A 1 73  ? 26.931  4.462   19.730  1.000 34.630  0 73  GLU A C     1 ? 
ATOM   582  O  O     . GLU A 1 73  ? 27.633  3.898   18.873  1.000 34.474  0 73  GLU A O     1 ? 
ATOM   583  C  CB    . GLU A 1 73  ? 27.324  3.108   21.918  1.000 37.782  0 73  GLU A CB    1 ? 
ATOM   584  C  CG    . GLU A 1 73  ? 28.313  4.155   22.423  1.000 40.996  0 73  GLU A CG    1 ? 
ATOM   585  C  CD    . GLU A 1 73  ? 29.444  3.594   23.281  1.000 43.403  0 73  GLU A CD    1 ? 
ATOM   586  O  OE1   . GLU A 1 73  ? 29.596  2.344   23.360  1.000 40.241  0 73  GLU A OE1   1 ? 
ATOM   587  O  OE2   . GLU A 1 73  ? 30.191  4.410   23.868  1.000 52.626  0 73  GLU A OE2   1 ? 
ATOM   588  N  N     . GLY A 1 74  ? 26.584  5.751   19.672  1.000 35.342  0 74  GLY A N     1 ? 
ATOM   589  C  CA    . GLY A 1 74  ? 27.115  6.684   18.655  1.000 37.457  0 74  GLY A CA    1 ? 
ATOM   590  C  C     . GLY A 1 74  ? 26.205  6.839   17.436  1.000 38.145  0 74  GLY A C     1 ? 
ATOM   591  O  O     . GLY A 1 74  ? 26.427  7.796   16.671  1.000 39.205  0 74  GLY A O     1 ? 
ATOM   592  N  N     . GLY A 1 75  ? 25.242  5.930   17.227  1.000 37.296  0 75  GLY A N     1 ? 
ATOM   593  C  CA    . GLY A 1 75  ? 24.189  6.068   16.198  1.000 35.211  0 75  GLY A CA    1 ? 
ATOM   594  C  C     . GLY A 1 75  ? 23.074  6.998   16.654  1.000 33.920  0 75  GLY A C     1 ? 
ATOM   595  O  O     . GLY A 1 75  ? 23.060  7.370   17.845  1.000 34.098  0 75  GLY A O     1 ? 
ATOM   596  N  N     . GLU A 1 76  ? 22.136  7.320   15.755  1.000 34.126  0 76  GLU A N     1 ? 
ATOM   597  C  CA    . GLU A 1 76  ? 20.980  8.219   16.020  1.000 34.773  0 76  GLU A CA    1 ? 
ATOM   598  C  C     . GLU A 1 76  ? 19.656  7.482   15.781  1.000 31.325  0 76  GLU A C     1 ? 
ATOM   599  O  O     . GLU A 1 76  ? 19.639  6.595   14.934  1.000 27.612  0 76  GLU A O     1 ? 
ATOM   600  C  CB    . GLU A 1 76  ? 21.092  9.454   15.126  1.000 38.576  0 76  GLU A CB    1 ? 
ATOM   601  C  CG    . GLU A 1 76  ? 22.284  10.329  15.477  1.000 42.054  0 76  GLU A CG    1 ? 
ATOM   602  C  CD    . GLU A 1 76  ? 22.333  11.669  14.765  1.000 44.259  0 76  GLU A CD    1 ? 
ATOM   603  O  OE1   . GLU A 1 76  ? 23.315  12.410  14.984  1.000 47.807  0 76  GLU A OE1   1 ? 
ATOM   604  O  OE2   . GLU A 1 76  ? 21.390  11.968  14.000  1.000 39.291  0 76  GLU A OE2   1 ? 
ATOM   605  N  N     . TYR A 1 77  ? 18.589  7.862   16.491  1.000 29.771  0 77  TYR A N     1 ? 
ATOM   606  C  CA    . TYR A 1 77  ? 17.191  7.459   16.173  1.000 31.619  0 77  TYR A CA    1 ? 
ATOM   607  C  C     . TYR A 1 77  ? 16.795  8.113   14.849  1.000 27.038  0 77  TYR A C     1 ? 
ATOM   608  O  O     . TYR A 1 77  ? 17.232  9.226   14.584  1.000 28.246  0 77  TYR A O     1 ? 
ATOM   609  C  CB    . TYR A 1 77  ? 16.218  7.797   17.311  1.000 31.437  0 77  TYR A CB    1 ? 
ATOM   610  C  CG    . TYR A 1 77  ? 16.441  6.918   18.507  1.000 33.877  0 77  TYR A CG    1 ? 
ATOM   611  C  CD1   . TYR A 1 77  ? 17.336  7.262   19.504  1.000 32.720  0 77  TYR A CD1   1 ? 
ATOM   612  C  CD2   . TYR A 1 77  ? 15.832  5.681   18.582  1.000 39.420  0 77  TYR A CD2   1 ? 
ATOM   613  C  CE1   . TYR A 1 77  ? 17.578  6.413   20.575  1.000 36.122  0 77  TYR A CE1   1 ? 
ATOM   614  C  CE2   . TYR A 1 77  ? 16.064  4.822   19.642  1.000 38.870  0 77  TYR A CE2   1 ? 
ATOM   615  C  CZ    . TYR A 1 77  ? 16.937  5.185   20.645  1.000 37.497  0 77  TYR A CZ    1 ? 
ATOM   616  O  OH    . TYR A 1 77  ? 17.142  4.299   21.670  1.000 38.394  0 77  TYR A OH    1 ? 
ATOM   617  N  N     . ASP A 1 78  ? 16.011  7.420   14.039  1.000 23.417  0 78  ASP A N     1 ? 
ATOM   618  C  CA    . ASP A 1 78  ? 15.593  7.901   12.699  1.000 25.659  0 78  ASP A CA    1 ? 
ATOM   619  C  C     . ASP A 1 78  ? 14.079  8.084   12.703  1.000 25.538  0 78  ASP A C     1 ? 
ATOM   620  O  O     . ASP A 1 78  ? 13.392  7.128   12.316  1.000 23.430  0 78  ASP A O     1 ? 
ATOM   621  C  CB    . ASP A 1 78  ? 16.049  6.915   11.620  1.000 27.789  0 78  ASP A CB    1 ? 
ATOM   622  C  CG    . ASP A 1 78  ? 15.561  7.240   10.222  1.000 27.756  0 78  ASP A CG    1 ? 
ATOM   623  O  OD1   . ASP A 1 78  ? 15.801  8.360   9.773   1.000 34.344  0 78  ASP A OD1   1 ? 
ATOM   624  O  OD2   . ASP A 1 78  ? 14.945  6.371   9.604   1.000 27.825  0 78  ASP A OD2   1 ? 
ATOM   625  N  N     . ILE A 1 79  ? 13.597  9.258   13.136  1.000 25.138  0 79  ILE A N     1 ? 
ATOM   626  C  CA    . ILE A 1 79  ? 12.150  9.558   13.330  1.000 23.667  0 79  ILE A CA    1 ? 
ATOM   627  C  C     . ILE A 1 79  ? 11.568  10.027  11.998  1.000 23.679  0 79  ILE A C     1 ? 
ATOM   628  O  O     . ILE A 1 79  ? 11.857  11.164  11.611  1.000 22.302  0 79  ILE A O     1 ? 
ATOM   629  C  CB    . ILE A 1 79  ? 11.945  10.607  14.435  1.000 26.224  0 79  ILE A CB    1 ? 
ATOM   630  C  CG1   . ILE A 1 79  ? 12.409  10.100  15.799  1.000 27.572  0 79  ILE A CG1   1 ? 
ATOM   631  C  CG2   . ILE A 1 79  ? 10.497  11.072  14.493  1.000 26.061  0 79  ILE A CG2   1 ? 
ATOM   632  C  CD1   . ILE A 1 79  ? 12.067  11.034  16.952  1.000 28.711  0 79  ILE A CD1   1 ? 
ATOM   633  N  N     . ASP A 1 80  ? 10.785  9.174   11.331  1.000 22.387  0 80  ASP A N     1 ? 
ATOM   634  C  CA    . ASP A 1 80  ? 10.228  9.458   9.990   1.000 22.144  0 80  ASP A CA    1 ? 
ATOM   635  C  C     . ASP A 1 80  ? 8.773   9.905   10.133  1.000 19.722  0 80  ASP A C     1 ? 
ATOM   636  O  O     . ASP A 1 80  ? 8.008   9.300   10.853  1.000 18.247  0 80  ASP A O     1 ? 
ATOM   637  C  CB    . ASP A 1 80  ? 10.357  8.269   9.038   1.000 25.022  0 80  ASP A CB    1 ? 
ATOM   638  C  CG    . ASP A 1 80  ? 11.774  7.754   8.881   1.000 26.696  0 80  ASP A CG    1 ? 
ATOM   639  O  OD1   . ASP A 1 80  ? 11.945  6.528   9.077   1.000 29.554  0 80  ASP A OD1   1 ? 
ATOM   640  O  OD2   . ASP A 1 80  ? 12.705  8.587   8.608   1.000 23.753  0 80  ASP A OD2   1 ? 
ATOM   641  N  N     . VAL A 1 81  ? 8.435   10.974  9.452   1.000 19.461  0 81  VAL A N     1 ? 
ATOM   642  C  CA    . VAL A 1 81  ? 7.089   11.596  9.500   1.000 21.132  0 81  VAL A CA    1 ? 
ATOM   643  C  C     . VAL A 1 81  ? 6.821   12.221  8.132   1.000 24.146  0 81  VAL A C     1 ? 
ATOM   644  O  O     . VAL A 1 81  ? 7.752   12.785  7.568   1.000 24.385  0 81  VAL A O     1 ? 
ATOM   645  C  CB    . VAL A 1 81  ? 7.033   12.613  10.651  1.000 19.884  0 81  VAL A CB    1 ? 
ATOM   646  C  CG1   . VAL A 1 81  ? 8.064   13.699  10.462  1.000 21.852  0 81  VAL A CG1   1 ? 
ATOM   647  C  CG2   . VAL A 1 81  ? 5.631   13.168  10.841  1.000 19.027  0 81  VAL A CG2   1 ? 
ATOM   648  N  N     . GLY A 1 82  ? 5.611   12.059  7.604   1.000 26.133  0 82  GLY A N     1 ? 
ATOM   649  C  CA    . GLY A 1 82  ? 5.163   12.722  6.366   1.000 25.096  0 82  GLY A CA    1 ? 
ATOM   650  C  C     . GLY A 1 82  ? 4.389   13.974  6.716   1.000 23.960  0 82  GLY A C     1 ? 
ATOM   651  O  O     . GLY A 1 82  ? 3.745   13.981  7.784   1.000 21.611  0 82  GLY A O     1 ? 
ATOM   652  N  N     . ILE A 1 83  ? 4.531   15.032  5.920   1.000 23.842  0 83  ILE A N     1 ? 
ATOM   653  C  CA    . ILE A 1 83  ? 3.640   16.220  6.035   1.000 24.265  0 83  ILE A CA    1 ? 
ATOM   654  C  C     . ILE A 1 83  ? 3.018   16.528  4.676   1.000 26.367  0 83  ILE A C     1 ? 
ATOM   655  O  O     . ILE A 1 83  ? 3.768   16.689  3.666   1.000 24.866  0 83  ILE A O     1 ? 
ATOM   656  C  CB    . ILE A 1 83  ? 4.329   17.433  6.669   1.000 21.810  0 83  ILE A CB    1 ? 
ATOM   657  C  CG1   . ILE A 1 83  ? 5.623   17.853  5.976   1.000 22.604  0 83  ILE A CG1   1 ? 
ATOM   658  C  CG2   . ILE A 1 83  ? 4.538   17.180  8.135   1.000 22.338  0 83  ILE A CG2   1 ? 
ATOM   659  C  CD1   . ILE A 1 83  ? 6.247   19.084  6.590   1.000 21.813  0 83  ILE A CD1   1 ? 
ATOM   660  N  N     . ILE A 1 84  ? 1.685   16.558  4.664   1.000 25.011  0 84  ILE A N     1 ? 
ATOM   661  C  CA    . ILE A 1 84  ? 0.862   16.895  3.477   1.000 25.008  0 84  ILE A CA    1 ? 
ATOM   662  C  C     . ILE A 1 84  ? 0.447   18.358  3.586   1.000 26.216  0 84  ILE A C     1 ? 
ATOM   663  O  O     . ILE A 1 84  ? -0.438  18.674  4.415   1.000 22.049  0 84  ILE A O     1 ? 
ATOM   664  C  CB    . ILE A 1 84  ? -0.340  15.960  3.375   1.000 27.767  0 84  ILE A CB    1 ? 
ATOM   665  C  CG1   . ILE A 1 84  ? 0.082   14.499  3.581   1.000 28.327  0 84  ILE A CG1   1 ? 
ATOM   666  C  CG2   . ILE A 1 84  ? -1.034  16.204  2.048   1.000 27.549  0 84  ILE A CG2   1 ? 
ATOM   667  C  CD1   . ILE A 1 84  ? -1.035  13.478  3.420   1.000 29.616  0 84  ILE A CD1   1 ? 
ATOM   668  N  N     . LEU A 1 85  ? 1.142   19.218  2.839   1.000 26.527  0 85  LEU A N     1 ? 
ATOM   669  C  CA    . LEU A 1 85  ? 0.917   20.685  2.837   1.000 28.207  0 85  LEU A CA    1 ? 
ATOM   670  C  C     . LEU A 1 85  ? -0.358  20.919  2.045   1.000 28.927  0 85  LEU A C     1 ? 
ATOM   671  O  O     . LEU A 1 85  ? -0.621  20.149  1.097   1.000 28.381  0 85  LEU A O     1 ? 
ATOM   672  C  CB    . LEU A 1 85  ? 2.091   21.420  2.185   1.000 28.426  0 85  LEU A CB    1 ? 
ATOM   673  C  CG    . LEU A 1 85  ? 3.335   21.632  3.048   1.000 29.929  0 85  LEU A CG    1 ? 
ATOM   674  C  CD1   . LEU A 1 85  ? 3.186   22.855  3.927   1.000 30.889  0 85  LEU A CD1   1 ? 
ATOM   675  C  CD2   . LEU A 1 85  ? 3.663   20.401  3.876   1.000 28.970  0 85  LEU A CD2   1 ? 
ATOM   676  N  N     . ASN A 1 86  ? -1.112  21.932  2.430   1.000 31.033  0 86  ASN A N     1 ? 
ATOM   677  C  CA    . ASN A 1 86  ? -2.408  22.253  1.801   1.000 34.053  0 86  ASN A CA    1 ? 
ATOM   678  C  C     . ASN A 1 86  ? -2.147  23.113  0.545   1.000 36.378  0 86  ASN A C     1 ? 
ATOM   679  O  O     . ASN A 1 86  ? -2.600  24.278  0.529   1.000 33.169  0 86  ASN A O     1 ? 
ATOM   680  C  CB    . ASN A 1 86  ? -3.304  22.880  2.862   1.000 35.133  0 86  ASN A CB    1 ? 
ATOM   681  C  CG    . ASN A 1 86  ? -4.653  23.278  2.323   1.000 43.533  0 86  ASN A CG    1 ? 
ATOM   682  O  OD1   . ASN A 1 86  ? -5.264  24.228  2.817   1.000 49.201  0 86  ASN A OD1   1 ? 
ATOM   683  N  ND2   . ASN A 1 86  ? -5.130  22.556  1.318   1.000 46.724  0 86  ASN A ND2   1 ? 
ATOM   684  N  N     . ILE A 1 87  ? -1.440  22.557  -0.459  1.000 34.681  0 87  ILE A N     1 ? 
ATOM   685  C  CA    . ILE A 1 87  ? -0.988  23.248  -1.718  1.000 34.113  0 87  ILE A CA    1 ? 
ATOM   686  C  C     . ILE A 1 87  ? -1.262  22.343  -2.924  1.000 32.950  0 87  ILE A C     1 ? 
ATOM   687  O  O     . ILE A 1 87  ? -1.379  21.123  -2.727  1.000 30.619  0 87  ILE A O     1 ? 
ATOM   688  C  CB    . ILE A 1 87  ? 0.513   23.601  -1.672  1.000 33.132  0 87  ILE A CB    1 ? 
ATOM   689  C  CG1   . ILE A 1 87  ? 1.379   22.336  -1.813  1.000 34.420  0 87  ILE A CG1   1 ? 
ATOM   690  C  CG2   . ILE A 1 87  ? 0.834   24.414  -0.419  1.000 33.263  0 87  ILE A CG2   1 ? 
ATOM   691  C  CD1   . ILE A 1 87  ? 2.891   22.570  -1.826  1.000 34.315  0 87  ILE A CD1   1 ? 
ATOM   692  N  N     . ALA A 1 88  ? -1.297  22.931  -4.125  1.000 30.418  0 88  ALA A N     1 ? 
ATOM   693  C  CA    . ALA A 1 88  ? -1.367  22.227  -5.418  1.000 28.555  0 88  ALA A CA    1 ? 
ATOM   694  C  C     . ALA A 1 88  ? 0.052   22.115  -5.954  1.000 30.620  0 88  ALA A C     1 ? 
ATOM   695  O  O     . ALA A 1 88  ? 0.752   23.134  -6.041  1.000 35.495  0 88  ALA A O     1 ? 
ATOM   696  C  CB    . ALA A 1 88  ? -2.278  22.951  -6.378  1.000 29.843  0 88  ALA A CB    1 ? 
ATOM   697  N  N     . LYS A 1 89  ? 0.489   20.900  -6.238  1.000 33.033  0 89  LYS A N     1 ? 
ATOM   698  C  CA    . LYS A 1 89  ? 1.887   20.633  -6.636  1.000 34.831  0 89  LYS A CA    1 ? 
ATOM   699  C  C     . LYS A 1 89  ? 2.210   21.451  -7.886  1.000 34.436  0 89  LYS A C     1 ? 
ATOM   700  O  O     . LYS A 1 89  ? 3.360   21.840  -8.027  1.000 31.119  0 89  LYS A O     1 ? 
ATOM   701  C  CB    . LYS A 1 89  ? 2.099   19.137  -6.862  1.000 34.963  0 89  LYS A CB    1 ? 
ATOM   702  C  CG    . LYS A 1 89  ? 1.533   18.560  -8.151  1.000 36.881  0 89  LYS A CG    1 ? 
ATOM   703  C  CD    . LYS A 1 89  ? 1.732   17.060  -8.247  1.000 37.731  0 89  LYS A CD    1 ? 
ATOM   704  C  CE    . LYS A 1 89  ? 0.785   16.411  -9.235  1.000 41.644  0 89  LYS A CE    1 ? 
ATOM   705  N  NZ    . LYS A 1 89  ? 1.279   16.524  -10.627 1.000 42.052  0 89  LYS A NZ    1 ? 
ATOM   706  N  N     . ASP A 1 90  ? 1.230   21.700  -8.756  1.000 34.024  0 90  ASP A N     1 ? 
ATOM   707  C  CA    . ASP A 1 90  ? 1.514   22.366  -10.059 1.000 34.314  0 90  ASP A CA    1 ? 
ATOM   708  C  C     . ASP A 1 90  ? 1.685   23.882  -9.845  1.000 35.628  0 90  ASP A C     1 ? 
ATOM   709  O  O     . ASP A 1 90  ? 2.294   24.520  -10.719 1.000 41.477  0 90  ASP A O     1 ? 
ATOM   710  C  CB    . ASP A 1 90  ? 0.479   21.980  -11.113 1.000 36.474  0 90  ASP A CB    1 ? 
ATOM   711  C  CG    . ASP A 1 90  ? 0.261   20.475  -11.197 1.000 38.068  0 90  ASP A CG    1 ? 
ATOM   712  O  OD1   . ASP A 1 90  ? 1.259   19.739  -11.322 1.000 35.710  0 90  ASP A OD1   1 ? 
ATOM   713  O  OD2   . ASP A 1 90  ? -0.909  20.048  -11.082 1.000 41.442  0 90  ASP A OD2   1 ? 
ATOM   714  N  N     . ASP A 1 91  ? 1.273   24.429  -8.699  1.000 33.218  0 91  ASP A N     1 ? 
ATOM   715  C  CA    . ASP A 1 91  ? 1.478   25.863  -8.346  1.000 33.221  0 91  ASP A CA    1 ? 
ATOM   716  C  C     . ASP A 1 91  ? 2.885   26.089  -7.786  1.000 31.635  0 91  ASP A C     1 ? 
ATOM   717  O  O     . ASP A 1 91  ? 3.223   27.261  -7.591  1.000 33.059  0 91  ASP A O     1 ? 
ATOM   718  C  CB    . ASP A 1 91  ? 0.465   26.369  -7.309  1.000 34.468  0 91  ASP A CB    1 ? 
ATOM   719  C  CG    . ASP A 1 91  ? -0.979  26.406  -7.793  1.000 38.275  0 91  ASP A CG    1 ? 
ATOM   720  O  OD1   . ASP A 1 91  ? -1.898  26.592  -6.945  1.000 36.823  0 91  ASP A OD1   1 ? 
ATOM   721  O  OD2   . ASP A 1 91  ? -1.183  26.212  -9.002  1.000 41.438  0 91  ASP A OD2   1 ? 
ATOM   722  N  N     . HIS A 1 92  ? 3.650   25.041  -7.442  1.000 30.941  0 92  HIS A N     1 ? 
ATOM   723  C  CA    . HIS A 1 92  ? 4.902   25.202  -6.640  1.000 28.890  0 92  HIS A CA    1 ? 
ATOM   724  C  C     . HIS A 1 92  ? 6.004   24.260  -7.097  1.000 28.297  0 92  HIS A C     1 ? 
ATOM   725  O  O     . HIS A 1 92  ? 5.692   23.111  -7.471  1.000 28.747  0 92  HIS A O     1 ? 
ATOM   726  C  CB    . HIS A 1 92  ? 4.639   25.006  -5.144  1.000 27.583  0 92  HIS A CB    1 ? 
ATOM   727  C  CG    . HIS A 1 92  ? 3.568   25.899  -4.626  1.000 28.442  0 92  HIS A CG    1 ? 
ATOM   728  N  ND1   . HIS A 1 92  ? 3.827   27.185  -4.183  1.000 27.797  0 92  HIS A ND1   1 ? 
ATOM   729  C  CD2   . HIS A 1 92  ? 2.237   25.728  -4.525  1.000 29.150  0 92  HIS A CD2   1 ? 
ATOM   730  C  CE1   . HIS A 1 92  ? 2.704   27.751  -3.803  1.000 27.504  0 92  HIS A CE1   1 ? 
ATOM   731  N  NE2   . HIS A 1 92  ? 1.712   26.883  -4.001  1.000 28.033  0 92  HIS A NE2   1 ? 
ATOM   732  N  N     . ASP A 1 93  ? 7.241   24.763  -7.066  1.000 28.814  0 93  ASP A N     1 ? 
ATOM   733  C  CA    . ASP A 1 93  ? 8.492   23.975  -7.203  1.000 30.967  0 93  ASP A CA    1 ? 
ATOM   734  C  C     . ASP A 1 93  ? 8.681   23.149  -5.930  1.000 29.211  0 93  ASP A C     1 ? 
ATOM   735  O  O     . ASP A 1 93  ? 8.448   23.647  -4.826  1.000 28.834  0 93  ASP A O     1 ? 
ATOM   736  C  CB    . ASP A 1 93  ? 9.703   24.881  -7.454  1.000 30.143  0 93  ASP A CB    1 ? 
ATOM   737  C  CG    . ASP A 1 93  ? 11.002  24.125  -7.680  1.000 33.517  0 93  ASP A CG    1 ? 
ATOM   738  O  OD1   . ASP A 1 93  ? 11.405  23.956  -8.872  1.000 37.618  0 93  ASP A OD1   1 ? 
ATOM   739  O  OD2   . ASP A 1 93  ? 11.609  23.724  -6.681  1.000 30.084  0 93  ASP A OD2   1 ? 
ATOM   740  N  N     . PRO A 1 94  ? 9.057   21.857  -6.051  1.000 28.342  0 94  PRO A N     1 ? 
ATOM   741  C  CA    . PRO A 1 94  ? 9.165   20.983  -4.876  1.000 27.837  0 94  PRO A CA    1 ? 
ATOM   742  C  C     . PRO A 1 94  ? 10.281  21.406  -3.897  1.000 28.038  0 94  PRO A C     1 ? 
ATOM   743  O  O     . PRO A 1 94  ? 10.112  21.311  -2.674  1.000 24.549  0 94  PRO A O     1 ? 
ATOM   744  C  CB    . PRO A 1 94  ? 9.385   19.577  -5.461  1.000 26.896  0 94  PRO A CB    1 ? 
ATOM   745  C  CG    . PRO A 1 94  ? 9.746   19.784  -6.950  1.000 28.434  0 94  PRO A CG    1 ? 
ATOM   746  C  CD    . PRO A 1 94  ? 9.227   21.148  -7.330  1.000 27.541  0 94  PRO A CD    1 ? 
ATOM   747  N  N     . VAL A 1 95  ? 11.396  21.902  -4.426  1.000 27.555  0 95  VAL A N     1 ? 
ATOM   748  C  CA    . VAL A 1 95  ? 12.561  22.309  -3.598  1.000 26.448  0 95  VAL A CA    1 ? 
ATOM   749  C  C     . VAL A 1 95  ? 12.201  23.620  -2.902  1.000 27.920  0 95  VAL A C     1 ? 
ATOM   750  O  O     . VAL A 1 95  ? 12.658  23.850  -1.743  1.000 25.799  0 95  VAL A O     1 ? 
ATOM   751  C  CB    . VAL A 1 95  ? 13.838  22.405  -4.457  1.000 28.557  0 95  VAL A CB    1 ? 
ATOM   752  C  CG1   . VAL A 1 95  ? 15.016  22.936  -3.662  1.000 27.611  0 95  VAL A CG1   1 ? 
ATOM   753  C  CG2   . VAL A 1 95  ? 14.184  21.063  -5.091  1.000 27.957  0 95  VAL A CG2   1 ? 
ATOM   754  N  N     . GLU A 1 96  ? 11.395  24.460  -3.561  1.000 27.841  0 96  GLU A N     1 ? 
ATOM   755  C  CA    . GLU A 1 96  ? 10.962  25.736  -2.958  1.000 27.968  0 96  GLU A CA    1 ? 
ATOM   756  C  C     . GLU A 1 96  ? 10.121  25.371  -1.738  1.000 26.194  0 96  GLU A C     1 ? 
ATOM   757  O  O     . GLU A 1 96  ? 10.326  25.959  -0.646  1.000 25.025  0 96  GLU A O     1 ? 
ATOM   758  C  CB    . GLU A 1 96  ? 10.239  26.601  -3.988  1.000 31.587  0 96  GLU A CB    1 ? 
ATOM   759  C  CG    . GLU A 1 96  ? 9.430   27.720  -3.376  1.000 32.415  0 96  GLU A CG    1 ? 
ATOM   760  C  CD    . GLU A 1 96  ? 10.218  28.940  -2.935  1.000 32.533  0 96  GLU A CD    1 ? 
ATOM   761  O  OE1   . GLU A 1 96  ? 11.444  28.967  -3.114  1.000 29.806  0 96  GLU A OE1   1 ? 
ATOM   762  O  OE2   . GLU A 1 96  ? 9.582   29.872  -2.442  1.000 32.336  0 96  GLU A OE2   1 ? 
ATOM   763  N  N     . VAL A 1 97  ? 9.281   24.356  -1.876  1.000 26.127  0 97  VAL A N     1 ? 
ATOM   764  C  CA    . VAL A 1 97  ? 8.402   23.935  -0.743  1.000 27.731  0 97  VAL A CA    1 ? 
ATOM   765  C  C     . VAL A 1 97  ? 9.283   23.380  0.386   1.000 24.490  0 97  VAL A C     1 ? 
ATOM   766  O  O     . VAL A 1 97  ? 9.094   23.810  1.526   1.000 21.866  0 97  VAL A O     1 ? 
ATOM   767  C  CB    . VAL A 1 97  ? 7.273   22.975  -1.169  1.000 25.622  0 97  VAL A CB    1 ? 
ATOM   768  C  CG1   . VAL A 1 97  ? 6.482   22.490  0.031   1.000 26.106  0 97  VAL A CG1   1 ? 
ATOM   769  C  CG2   . VAL A 1 97  ? 6.337   23.639  -2.153  1.000 26.905  0 97  VAL A CG2   1 ? 
ATOM   770  N  N     . LYS A 1 98  ? 10.290  22.560  0.088   1.000 25.945  0 98  LYS A N     1 ? 
ATOM   771  C  CA    . LYS A 1 98  ? 11.194  22.044  1.159   1.000 26.461  0 98  LYS A CA    1 ? 
ATOM   772  C  C     . LYS A 1 98  ? 11.975  23.197  1.803   1.000 28.204  0 98  LYS A C     1 ? 
ATOM   773  O  O     . LYS A 1 98  ? 12.321  23.070  2.986   1.000 22.492  0 98  LYS A O     1 ? 
ATOM   774  C  CB    . LYS A 1 98  ? 12.128  20.972  0.607   1.000 26.012  0 98  LYS A CB    1 ? 
ATOM   775  C  CG    . LYS A 1 98  ? 11.410  19.676  0.250   1.000 28.649  0 98  LYS A CG    1 ? 
ATOM   776  C  CD    . LYS A 1 98  ? 12.338  18.481  0.077   1.000 29.208  0 98  LYS A CD    1 ? 
ATOM   777  C  CE    . LYS A 1 98  ? 13.082  18.527  -1.238  1.000 27.900  0 98  LYS A CE    1 ? 
ATOM   778  N  NZ    . LYS A 1 98  ? 13.528  17.180  -1.658  1.000 28.698  0 98  LYS A NZ    1 ? 
ATOM   779  N  N     . LYS A 1 99  ? 12.269  24.264  1.044   1.000 29.167  0 99  LYS A N     1 ? 
ATOM   780  C  CA    . LYS A 1 99  ? 12.930  25.490  1.576   1.000 29.414  0 99  LYS A CA    1 ? 
ATOM   781  C  C     . LYS A 1 99  ? 12.071  26.126  2.662   1.000 25.882  0 99  LYS A C     1 ? 
ATOM   782  O  O     . LYS A 1 99  ? 12.670  26.573  3.635   1.000 27.379  0 99  LYS A O     1 ? 
ATOM   783  C  CB    . LYS A 1 99  ? 13.215  26.525  0.489   1.000 31.203  0 99  LYS A CB    1 ? 
ATOM   784  C  CG    . LYS A 1 99  ? 14.548  26.358  -0.220  1.000 31.820  0 99  LYS A CG    1 ? 
ATOM   785  C  CD    . LYS A 1 99  ? 14.700  27.288  -1.415  1.000 32.317  0 99  LYS A CD    1 ? 
ATOM   786  C  CE    . LYS A 1 99  ? 15.845  26.879  -2.315  1.000 34.923  0 99  LYS A CE    1 ? 
ATOM   787  N  NZ    . LYS A 1 99  ? 15.770  27.524  -3.645  1.000 36.658  0 99  LYS A NZ    1 ? 
ATOM   788  N  N     . TRP A 1 100 ? 10.740  26.174  2.502   1.000 27.623  0 100 TRP A N     1 ? 
ATOM   789  C  CA    . TRP A 1 100 ? 9.804   26.719  3.535   1.000 29.289  0 100 TRP A CA    1 ? 
ATOM   790  C  C     . TRP A 1 100 ? 10.040  26.017  4.863   1.000 29.167  0 100 TRP A C     1 ? 
ATOM   791  O  O     . TRP A 1 100 ? 10.056  26.693  5.920   1.000 29.890  0 100 TRP A O     1 ? 
ATOM   792  C  CB    . TRP A 1 100 ? 8.331   26.534  3.165   1.000 29.164  0 100 TRP A CB    1 ? 
ATOM   793  C  CG    . TRP A 1 100 ? 7.941   27.149  1.866   1.000 31.539  0 100 TRP A CG    1 ? 
ATOM   794  C  CD1   . TRP A 1 100 ? 8.659   28.039  1.119   1.000 30.829  0 100 TRP A CD1   1 ? 
ATOM   795  C  CD2   . TRP A 1 100 ? 6.710   26.916  1.158   1.000 33.598  0 100 TRP A CD2   1 ? 
ATOM   796  N  NE1   . TRP A 1 100 ? 7.953   28.384  -0.006  1.000 33.487  0 100 TRP A NE1   1 ? 
ATOM   797  C  CE2   . TRP A 1 100 ? 6.764   27.694  -0.022  1.000 34.711  0 100 TRP A CE2   1 ? 
ATOM   798  C  CE3   . TRP A 1 100 ? 5.579   26.127  1.405   1.000 35.820  0 100 TRP A CE3   1 ? 
ATOM   799  C  CZ2   . TRP A 1 100 ? 5.730   27.695  -0.954  1.000 34.524  0 100 TRP A CZ2   1 ? 
ATOM   800  C  CZ3   . TRP A 1 100 ? 4.549   26.139  0.488   1.000 36.748  0 100 TRP A CZ3   1 ? 
ATOM   801  C  CH2   . TRP A 1 100 ? 4.623   26.923  -0.669  1.000 37.205  0 100 TRP A CH2   1 ? 
ATOM   802  N  N     . ILE A 1 101 ? 10.113  24.693  4.783   1.000 28.389  0 101 ILE A N     1 ? 
ATOM   803  C  CA    . ILE A 1 101 ? 10.216  23.783  5.956   1.000 28.804  0 101 ILE A CA    1 ? 
ATOM   804  C  C     . ILE A 1 101 ? 11.592  24.031  6.575   1.000 28.188  0 101 ILE A C     1 ? 
ATOM   805  O  O     . ILE A 1 101 ? 11.679  24.296  7.790   1.000 27.324  0 101 ILE A O     1 ? 
ATOM   806  C  CB    . ILE A 1 101 ? 10.002  22.307  5.538   1.000 28.142  0 101 ILE A CB    1 ? 
ATOM   807  C  CG1   . ILE A 1 101 ? 8.836   22.132  4.560   1.000 27.847  0 101 ILE A CG1   1 ? 
ATOM   808  C  CG2   . ILE A 1 101 ? 9.822   21.421  6.764   1.000 27.432  0 101 ILE A CG2   1 ? 
ATOM   809  C  CD1   . ILE A 1 101 ? 7.491   22.567  5.131   1.000 28.080  0 101 ILE A CD1   1 ? 
ATOM   810  N  N     . ARG A 1 102 ? 12.635  24.000  5.754   1.000 29.688  0 102 ARG A N     1 ? 
ATOM   811  C  CA    . ARG A 1 102 ? 14.008  24.309  6.230   1.000 33.759  0 102 ARG A CA    1 ? 
ATOM   812  C  C     . ARG A 1 102 ? 13.986  25.663  6.958   1.000 35.042  0 102 ARG A C     1 ? 
ATOM   813  O  O     . ARG A 1 102 ? 14.408  25.704  8.130   1.000 33.822  0 102 ARG A O     1 ? 
ATOM   814  C  CB    . ARG A 1 102 ? 15.006  24.274  5.074   1.000 32.779  0 102 ARG A CB    1 ? 
ATOM   815  C  CG    . ARG A 1 102 ? 16.463  24.279  5.514   1.000 36.853  0 102 ARG A CG    1 ? 
ATOM   816  C  CD    . ARG A 1 102 ? 17.072  25.674  5.589   1.000 38.321  0 102 ARG A CD    1 ? 
ATOM   817  N  NE    . ARG A 1 102 ? 16.783  26.533  4.442   1.000 38.802  0 102 ARG A NE    1 ? 
ATOM   818  C  CZ    . ARG A 1 102 ? 17.415  26.498  3.267   1.000 39.502  0 102 ARG A CZ    1 ? 
ATOM   819  N  NH1   . ARG A 1 102 ? 18.365  25.611  3.031   1.000 40.393  0 102 ARG A NH1   1 ? 
ATOM   820  N  NH2   . ARG A 1 102 ? 17.074  27.345  2.315   1.000 41.196  0 102 ARG A NH2   1 ? 
ATOM   821  N  N     . ASP A 1 103 ? 13.470  26.723  6.318   1.000 36.771  0 103 ASP A N     1 ? 
ATOM   822  C  CA    . ASP A 1 103 ? 13.494  28.103  6.881   1.000 33.748  0 103 ASP A CA    1 ? 
ATOM   823  C  C     . ASP A 1 103 ? 12.749  28.106  8.225   1.000 34.194  0 103 ASP A C     1 ? 
ATOM   824  O  O     . ASP A 1 103 ? 13.244  28.749  9.182   1.000 35.452  0 103 ASP A O     1 ? 
ATOM   825  C  CB    . ASP A 1 103 ? 12.958  29.128  5.873   1.000 32.614  0 103 ASP A CB    1 ? 
ATOM   826  C  CG    . ASP A 1 103 ? 13.836  29.255  4.640   1.000 32.182  0 103 ASP A CG    1 ? 
ATOM   827  O  OD1   . ASP A 1 103 ? 13.394  29.886  3.667   1.000 34.478  0 103 ASP A OD1   1 ? 
ATOM   828  O  OD2   . ASP A 1 103 ? 14.935  28.662  4.646   1.000 33.053  0 103 ASP A OD2   1 ? 
ATOM   829  N  N     . ALA A 1 104 ? 11.639  27.374  8.327   1.000 32.389  0 104 ALA A N     1 ? 
ATOM   830  C  CA    . ALA A 1 104 ? 10.781  27.328  9.539   1.000 31.011  0 104 ALA A CA    1 ? 
ATOM   831  C  C     . ALA A 1 104 ? 11.527  26.687  10.712  1.000 33.050  0 104 ALA A C     1 ? 
ATOM   832  O  O     . ALA A 1 104 ? 11.227  27.047  11.868  1.000 31.888  0 104 ALA A O     1 ? 
ATOM   833  C  CB    . ALA A 1 104 ? 9.509   26.575  9.245   1.000 31.785  0 104 ALA A CB    1 ? 
ATOM   834  N  N     . LEU A 1 105 ? 12.429  25.750  10.430  1.000 33.142  0 105 LEU A N     1 ? 
ATOM   835  C  CA    . LEU A 1 105 ? 13.187  24.986  11.460  1.000 38.854  0 105 LEU A CA    1 ? 
ATOM   836  C  C     . LEU A 1 105 ? 14.605  25.546  11.612  1.000 47.508  0 105 LEU A C     1 ? 
ATOM   837  O  O     . LEU A 1 105 ? 15.475  24.811  12.161  1.000 52.992  0 105 LEU A O     1 ? 
ATOM   838  C  CB    . LEU A 1 105 ? 13.231  23.519  11.029  1.000 37.525  0 105 LEU A CB    1 ? 
ATOM   839  C  CG    . LEU A 1 105 ? 11.864  22.853  10.945  1.000 35.264  0 105 LEU A CG    1 ? 
ATOM   840  C  CD1   . LEU A 1 105 ? 11.941  21.559  10.164  1.000 36.490  0 105 LEU A CD1   1 ? 
ATOM   841  C  CD2   . LEU A 1 105 ? 11.307  22.618  12.336  1.000 34.328  0 105 LEU A CD2   1 ? 
ATOM   842  N  N     . LYS A 1 106 ? 14.838  26.781  11.161  1.000 51.715  0 106 LYS A N     1 ? 
ATOM   843  C  CA    . LYS A 1 106 ? 16.208  27.346  11.054  1.000 61.080  0 106 LYS A CA    1 ? 
ATOM   844  C  C     . LYS A 1 106 ? 16.906  27.199  12.413  1.000 62.366  0 106 LYS A C     1 ? 
ATOM   845  O  O     . LYS A 1 106 ? 17.992  26.555  12.469  1.000 56.578  0 106 LYS A O     1 ? 
ATOM   846  C  CB    . LYS A 1 106 ? 16.187  28.808  10.589  1.000 66.789  0 106 LYS A CB    1 ? 
ATOM   847  C  CG    . LYS A 1 106 ? 17.058  29.101  9.370   1.000 73.567  0 106 LYS A CG    1 ? 
ATOM   848  C  CD    . LYS A 1 106 ? 18.546  28.817  9.575   1.000 78.392  0 106 LYS A CD    1 ? 
ATOM   849  C  CE    . LYS A 1 106 ? 19.277  28.482  8.287   1.000 80.469  0 106 LYS A CE    1 ? 
ATOM   850  N  NZ    . LYS A 1 106 ? 20.696  28.125  8.530   1.000 77.327  0 106 LYS A NZ    1 ? 
ATOM   851  N  N     . ASP A 1 107 ? 16.284  27.742  13.464  1.000 63.380  0 107 ASP A N     1 ? 
ATOM   852  C  CA    . ASP A 1 107 ? 16.912  27.942  14.797  1.000 68.086  0 107 ASP A CA    1 ? 
ATOM   853  C  C     . ASP A 1 107 ? 16.698  26.712  15.682  1.000 65.627  0 107 ASP A C     1 ? 
ATOM   854  O  O     . ASP A 1 107 ? 17.351  26.635  16.744  1.000 70.569  0 107 ASP A O     1 ? 
ATOM   855  C  CB    . ASP A 1 107 ? 16.353  29.192  15.478  1.000 68.356  0 107 ASP A CB    1 ? 
ATOM   856  C  CG    . ASP A 1 107 ? 16.656  30.459  14.710  1.000 66.801  0 107 ASP A CG    1 ? 
ATOM   857  O  OD1   . ASP A 1 107 ? 17.812  30.593  14.252  1.000 62.447  0 107 ASP A OD1   1 ? 
ATOM   858  O  OD2   . ASP A 1 107 ? 15.732  31.287  14.559  1.000 64.959  0 107 ASP A OD2   1 ? 
ATOM   859  N  N     . TYR A 1 108 ? 15.806  25.803  15.283  1.000 63.693  0 108 TYR A N     1 ? 
ATOM   860  C  CA    . TYR A 1 108 ? 15.401  24.643  16.115  1.000 59.991  0 108 TYR A CA    1 ? 
ATOM   861  C  C     . TYR A 1 108 ? 16.521  23.597  16.065  1.000 59.429  0 108 TYR A C     1 ? 
ATOM   862  O  O     . TYR A 1 108 ? 17.204  23.452  15.015  1.000 48.822  0 108 TYR A O     1 ? 
ATOM   863  C  CB    . TYR A 1 108 ? 14.033  24.100  15.688  1.000 56.870  0 108 TYR A CB    1 ? 
ATOM   864  C  CG    . TYR A 1 108 ? 13.561  22.918  16.497  1.000 51.045  0 108 TYR A CG    1 ? 
ATOM   865  C  CD1   . TYR A 1 108 ? 12.722  23.078  17.586  1.000 48.090  0 108 TYR A CD1   1 ? 
ATOM   866  C  CD2   . TYR A 1 108 ? 13.990  21.633  16.195  1.000 53.347  0 108 TYR A CD2   1 ? 
ATOM   867  C  CE1   . TYR A 1 108 ? 12.315  21.993  18.352  1.000 47.504  0 108 TYR A CE1   1 ? 
ATOM   868  C  CE2   . TYR A 1 108 ? 13.587  20.536  16.942  1.000 50.873  0 108 TYR A CE2   1 ? 
ATOM   869  C  CZ    . TYR A 1 108 ? 12.745  20.718  18.026  1.000 48.101  0 108 TYR A CZ    1 ? 
ATOM   870  O  OH    . TYR A 1 108 ? 12.347  19.650  18.767  1.000 47.687  0 108 TYR A OH    1 ? 
ATOM   871  N  N     . GLY A 1 109 ? 16.705  22.907  17.193  1.000 64.402  0 109 GLY A N     1 ? 
ATOM   872  C  CA    . GLY A 1 109 ? 17.721  21.858  17.385  1.000 63.666  0 109 GLY A CA    1 ? 
ATOM   873  C  C     . GLY A 1 109 ? 19.056  22.284  16.814  1.000 64.983  0 109 GLY A C     1 ? 
ATOM   874  O  O     . GLY A 1 109 ? 19.426  23.461  17.003  1.000 62.496  0 109 GLY A O     1 ? 
ATOM   875  N  N     . ASN A 1 110 ? 19.727  21.370  16.106  1.000 64.755  0 110 ASN A N     1 ? 
ATOM   876  C  CA    . ASN A 1 110 ? 21.108  21.541  15.580  1.000 65.141  0 110 ASN A CA    1 ? 
ATOM   877  C  C     . ASN A 1 110 ? 21.042  21.879  14.078  1.000 64.234  0 110 ASN A C     1 ? 
ATOM   878  O  O     . ASN A 1 110 ? 21.969  21.474  13.343  1.000 66.717  0 110 ASN A O     1 ? 
ATOM   879  C  CB    . ASN A 1 110 ? 21.964  20.300  15.883  1.000 70.052  0 110 ASN A CB    1 ? 
ATOM   880  C  CG    . ASN A 1 110 ? 22.019  19.941  17.360  1.000 75.061  0 110 ASN A CG    1 ? 
ATOM   881  O  OD1   . ASN A 1 110 ? 21.947  18.767  17.733  1.000 75.786  0 110 ASN A OD1   1 ? 
ATOM   882  N  ND2   . ASN A 1 110 ? 22.152  20.943  18.216  1.000 73.532  0 110 ASN A ND2   1 ? 
ATOM   883  N  N     . GLY A 1 111 ? 20.001  22.609  13.646  1.000 61.897  0 111 GLY A N     1 ? 
ATOM   884  C  CA    . GLY A 1 111 ? 19.807  23.066  12.254  1.000 55.539  0 111 GLY A CA    1 ? 
ATOM   885  C  C     . GLY A 1 111 ? 19.085  22.034  11.396  1.000 50.840  0 111 GLY A C     1 ? 
ATOM   886  O  O     . GLY A 1 111 ? 18.909  20.878  11.851  1.000 50.837  0 111 GLY A O     1 ? 
ATOM   887  N  N     . ALA A 1 112 ? 18.701  22.434  10.182  1.000 45.925  0 112 ALA A N     1 ? 
ATOM   888  C  CA    . ALA A 1 112 ? 17.883  21.652  9.229   1.000 41.284  0 112 ALA A CA    1 ? 
ATOM   889  C  C     . ALA A 1 112 ? 18.590  21.593  7.878   1.000 39.520  0 112 ALA A C     1 ? 
ATOM   890  O  O     . ALA A 1 112 ? 19.335  22.523  7.547   1.000 42.481  0 112 ALA A O     1 ? 
ATOM   891  C  CB    . ALA A 1 112 ? 16.525  22.270  9.093   1.000 41.206  0 112 ALA A CB    1 ? 
ATOM   892  N  N     . GLU A 1 113 ? 18.320  20.548  7.118   1.000 34.462  0 113 GLU A N     1 ? 
ATOM   893  C  CA    . GLU A 1 113 ? 19.044  20.210  5.874   1.000 36.394  0 113 GLU A CA    1 ? 
ATOM   894  C  C     . GLU A 1 113 ? 18.034  19.691  4.851   1.000 34.034  0 113 GLU A C     1 ? 
ATOM   895  O  O     . GLU A 1 113 ? 17.268  18.760  5.193   1.000 33.129  0 113 GLU A O     1 ? 
ATOM   896  C  CB    . GLU A 1 113 ? 20.098  19.166  6.231   1.000 41.503  0 113 GLU A CB    1 ? 
ATOM   897  C  CG    . GLU A 1 113 ? 20.740  18.495  5.047   1.000 48.307  0 113 GLU A CG    1 ? 
ATOM   898  C  CD    . GLU A 1 113 ? 22.110  17.927  5.374   1.000 53.660  0 113 GLU A CD    1 ? 
ATOM   899  O  OE1   . GLU A 1 113 ? 22.571  18.111  6.529   1.000 54.400  0 113 GLU A OE1   1 ? 
ATOM   900  O  OE2   . GLU A 1 113 ? 22.726  17.333  4.471   1.000 61.279  0 113 GLU A OE2   1 ? 
ATOM   901  N  N     . ILE A 1 114 ? 18.025  20.255  3.648   1.000 29.938  0 114 ILE A N     1 ? 
ATOM   902  C  CA    . ILE A 1 114 ? 17.202  19.720  2.537   1.000 30.522  0 114 ILE A CA    1 ? 
ATOM   903  C  C     . ILE A 1 114 ? 17.956  18.542  1.929   1.000 31.428  0 114 ILE A C     1 ? 
ATOM   904  O  O     . ILE A 1 114 ? 19.019  18.758  1.291   1.000 28.616  0 114 ILE A O     1 ? 
ATOM   905  C  CB    . ILE A 1 114 ? 16.866  20.768  1.465   1.000 29.002  0 114 ILE A CB    1 ? 
ATOM   906  C  CG1   . ILE A 1 114 ? 16.059  21.932  2.037   1.000 30.427  0 114 ILE A CG1   1 ? 
ATOM   907  C  CG2   . ILE A 1 114 ? 16.140  20.102  0.307   1.000 26.325  0 114 ILE A CG2   1 ? 
ATOM   908  C  CD1   . ILE A 1 114 ? 15.780  23.032  1.026   1.000 29.902  0 114 ILE A CD1   1 ? 
ATOM   909  N  N     . ARG A 1 115 ? 17.400  17.349  2.100   1.000 30.040  0 115 ARG A N     1 ? 
ATOM   910  C  CA    . ARG A 1 115 ? 17.875  16.118  1.437   1.000 31.333  0 115 ARG A CA    1 ? 
ATOM   911  C  C     . ARG A 1 115 ? 17.007  15.911  0.204   1.000 28.424  0 115 ARG A C     1 ? 
ATOM   912  O  O     . ARG A 1 115 ? 16.002  16.643  0.046   1.000 27.200  0 115 ARG A O     1 ? 
ATOM   913  C  CB    . ARG A 1 115 ? 17.788  14.940  2.408   1.000 33.870  0 115 ARG A CB    1 ? 
ATOM   914  C  CG    . ARG A 1 115 ? 18.622  15.132  3.664   1.000 38.430  0 115 ARG A CG    1 ? 
ATOM   915  C  CD    . ARG A 1 115 ? 19.901  14.334  3.552   1.000 45.187  0 115 ARG A CD    1 ? 
ATOM   916  N  NE    . ARG A 1 115 ? 20.764  14.514  4.705   1.000 49.969  0 115 ARG A NE    1 ? 
ATOM   917  C  CZ    . ARG A 1 115 ? 20.665  13.840  5.841   1.000 52.787  0 115 ARG A CZ    1 ? 
ATOM   918  N  NH1   . ARG A 1 115 ? 19.715  12.932  6.005   1.000 53.046  0 115 ARG A NH1   1 ? 
ATOM   919  N  NH2   . ARG A 1 115 ? 21.516  14.091  6.821   1.000 55.672  0 115 ARG A NH2   1 ? 
ATOM   920  N  N     . ARG A 1 116 ? 17.364  14.933  -0.612  1.000 25.993  0 116 ARG A N     1 ? 
ATOM   921  C  CA    . ARG A 1 116 ? 16.719  14.694  -1.916  1.000 30.573  0 116 ARG A CA    1 ? 
ATOM   922  C  C     . ARG A 1 116 ? 15.230  14.408  -1.701  1.000 27.904  0 116 ARG A C     1 ? 
ATOM   923  O  O     . ARG A 1 116 ? 14.455  14.756  -2.568  1.000 24.255  0 116 ARG A O     1 ? 
ATOM   924  C  CB    . ARG A 1 116 ? 17.428  13.546  -2.640  1.000 34.289  0 116 ARG A CB    1 ? 
ATOM   925  C  CG    . ARG A 1 116 ? 16.932  13.330  -4.060  1.000 42.662  0 116 ARG A CG    1 ? 
ATOM   926  C  CD    . ARG A 1 116 ? 17.540  12.086  -4.668  1.000 48.874  0 116 ARG A CD    1 ? 
ATOM   927  N  NE    . ARG A 1 116 ? 17.479  12.090  -6.117  1.000 57.788  0 116 ARG A NE    1 ? 
ATOM   928  C  CZ    . ARG A 1 116 ? 18.277  12.805  -6.912  1.000 63.497  0 116 ARG A CZ    1 ? 
ATOM   929  N  NH1   . ARG A 1 116 ? 19.198  13.608  -6.401  1.000 62.445  0 116 ARG A NH1   1 ? 
ATOM   930  N  NH2   . ARG A 1 116 ? 18.148  12.711  -8.225  1.000 69.845  0 116 ARG A NH2   1 ? 
ATOM   931  N  N     . SER A 1 117 ? 14.882  13.749  -0.601  1.000 26.451  0 117 SER A N     1 ? 
ATOM   932  C  CA    . SER A 1 117 ? 13.567  13.098  -0.393  1.000 27.948  0 117 SER A CA    1 ? 
ATOM   933  C  C     . SER A 1 117 ? 12.945  13.546  0.936   1.000 25.486  0 117 SER A C     1 ? 
ATOM   934  O  O     . SER A 1 117 ? 11.845  13.073  1.274   1.000 23.948  0 117 SER A O     1 ? 
ATOM   935  C  CB    . SER A 1 117 ? 13.725  11.606  -0.496  1.000 29.714  0 117 SER A CB    1 ? 
ATOM   936  O  OG    . SER A 1 117 ? 14.279  11.240  -1.771  1.000 31.585  0 117 SER A OG    1 ? 
ATOM   937  N  N     . CYS A 1 118 ? 13.558  14.502  1.622   1.000 23.807  0 118 CYS A N     1 ? 
ATOM   938  C  CA    . CYS A 1 118 ? 13.033  15.003  2.913   1.000 24.162  0 118 CYS A CA    1 ? 
ATOM   939  C  C     . CYS A 1 118 ? 13.806  16.244  3.353   1.000 24.531  0 118 CYS A C     1 ? 
ATOM   940  O  O     . CYS A 1 118 ? 14.829  16.581  2.715   1.000 26.818  0 118 CYS A O     1 ? 
ATOM   941  C  CB    . CYS A 1 118 ? 13.103  13.917  3.988   1.000 22.373  0 118 CYS A CB    1 ? 
ATOM   942  S  SG    . CYS A 1 118 ? 14.779  13.309  4.326   1.000 25.073  0 118 CYS A SG    1 ? 
ATOM   943  N  N     . VAL A 1 119 ? 13.281  16.896  4.380   1.000 23.045  0 119 VAL A N     1 ? 
ATOM   944  C  CA    . VAL A 1 119 ? 13.995  17.856  5.255   1.000 23.961  0 119 VAL A CA    1 ? 
ATOM   945  C  C     . VAL A 1 119 ? 14.260  17.170  6.606   1.000 23.130  0 119 VAL A C     1 ? 
ATOM   946  O  O     . VAL A 1 119 ? 13.305  16.649  7.249   1.000 23.554  0 119 VAL A O     1 ? 
ATOM   947  C  CB    . VAL A 1 119 ? 13.199  19.163  5.404   1.000 24.379  0 119 VAL A CB    1 ? 
ATOM   948  C  CG1   . VAL A 1 119 ? 13.902  20.138  6.332   1.000 24.464  0 119 VAL A CG1   1 ? 
ATOM   949  C  CG2   . VAL A 1 119 ? 12.932  19.800  4.048   1.000 23.735  0 119 VAL A CG2   1 ? 
ATOM   950  N  N     . THR A 1 120 ? 15.533  17.102  6.993   1.000 23.721  0 120 THR A N     1 ? 
ATOM   951  C  CA    . THR A 1 120 ? 15.991  16.428  8.223   1.000 24.973  0 120 THR A CA    1 ? 
ATOM   952  C  C     . THR A 1 120 ? 16.384  17.507  9.205   1.000 25.660  0 120 THR A C     1 ? 
ATOM   953  O  O     . THR A 1 120 ? 17.139  18.385  8.795   1.000 25.372  0 120 THR A O     1 ? 
ATOM   954  C  CB    . THR A 1 120 ? 17.168  15.503  7.935   1.000 25.800  0 120 THR A CB    1 ? 
ATOM   955  O  OG1   . THR A 1 120 ? 16.675  14.482  7.072   1.000 29.608  0 120 THR A OG1   1 ? 
ATOM   956  C  CG2   . THR A 1 120 ? 17.752  14.907  9.190   1.000 26.576  0 120 THR A CG2   1 ? 
ATOM   957  N  N     . VAL A 1 121 ? 15.853  17.432  10.419  1.000 28.939  0 121 VAL A N     1 ? 
ATOM   958  C  CA    . VAL A 1 121 ? 16.219  18.316  11.555  1.000 34.439  0 121 VAL A CA    1 ? 
ATOM   959  C  C     . VAL A 1 121 ? 16.928  17.456  12.601  1.000 35.260  0 121 VAL A C     1 ? 
ATOM   960  O  O     . VAL A 1 121 ? 16.468  16.329  12.847  1.000 31.418  0 121 VAL A O     1 ? 
ATOM   961  C  CB    . VAL A 1 121 ? 14.989  19.052  12.126  1.000 40.390  0 121 VAL A CB    1 ? 
ATOM   962  C  CG1   . VAL A 1 121 ? 13.865  18.112  12.517  1.000 43.701  0 121 VAL A CG1   1 ? 
ATOM   963  C  CG2   . VAL A 1 121 ? 15.357  19.938  13.298  1.000 44.930  0 121 VAL A CG2   1 ? 
ATOM   964  N  N     . PHE A 1 122 ? 18.013  17.978  13.183  1.000 36.816  0 122 PHE A N     1 ? 
ATOM   965  C  CA    . PHE A 1 122 ? 18.943  17.229  14.065  1.000 37.730  0 122 PHE A CA    1 ? 
ATOM   966  C  C     . PHE A 1 122 ? 18.708  17.598  15.538  1.000 40.215  0 122 PHE A C     1 ? 
ATOM   967  O  O     . PHE A 1 122 ? 18.430  18.773  15.892  1.000 44.495  0 122 PHE A O     1 ? 
ATOM   968  C  CB    . PHE A 1 122 ? 20.381  17.448  13.595  1.000 36.742  0 122 PHE A CB    1 ? 
ATOM   969  C  CG    . PHE A 1 122 ? 20.613  17.031  12.164  1.000 37.516  0 122 PHE A CG    1 ? 
ATOM   970  C  CD1   . PHE A 1 122 ? 20.780  15.699  11.836  1.000 36.410  0 122 PHE A CD1   1 ? 
ATOM   971  C  CD2   . PHE A 1 122 ? 20.648  17.971  11.140  1.000 40.991  0 122 PHE A CD2   1 ? 
ATOM   972  C  CE1   . PHE A 1 122 ? 20.978  15.312  10.519  1.000 38.454  0 122 PHE A CE1   1 ? 
ATOM   973  C  CE2   . PHE A 1 122 ? 20.833  17.580  9.819   1.000 39.827  0 122 PHE A CE2   1 ? 
ATOM   974  C  CZ    . PHE A 1 122 ? 21.009  16.253  9.511   1.000 37.300  0 122 PHE A CZ    1 ? 
ATOM   975  N  N     . LYS A 1 123 ? 18.805  16.580  16.384  1.000 39.876  0 123 LYS A N     1 ? 
ATOM   976  C  CA    . LYS A 1 123 ? 18.787  16.678  17.861  1.000 39.723  0 123 LYS A CA    1 ? 
ATOM   977  C  C     . LYS A 1 123 ? 19.879  15.761  18.383  1.000 41.897  0 123 LYS A C     1 ? 
ATOM   978  O  O     . LYS A 1 123 ? 20.351  14.896  17.651  1.000 36.116  0 123 LYS A O     1 ? 
ATOM   979  C  CB    . LYS A 1 123 ? 17.413  16.281  18.403  1.000 45.009  0 123 LYS A CB    1 ? 
ATOM   980  C  CG    . LYS A 1 123 ? 16.435  17.436  18.528  1.000 48.815  0 123 LYS A CG    1 ? 
ATOM   981  C  CD    . LYS A 1 123 ? 16.677  18.272  19.758  1.000 51.838  0 123 LYS A CD    1 ? 
ATOM   982  C  CE    . LYS A 1 123 ? 15.845  19.537  19.790  1.000 56.215  0 123 LYS A CE    1 ? 
ATOM   983  N  NZ    . LYS A 1 123 ? 15.849  20.158  21.139  1.000 56.398  0 123 LYS A NZ    1 ? 
ATOM   984  N  N     . PRO A 1 124 ? 20.361  15.957  19.630  1.000 43.429  0 124 PRO A N     1 ? 
ATOM   985  C  CA    . PRO A 1 124 ? 21.319  15.028  20.217  1.000 41.012  0 124 PRO A CA    1 ? 
ATOM   986  C  C     . PRO A 1 124 ? 20.654  13.649  20.325  1.000 36.353  0 124 PRO A C     1 ? 
ATOM   987  O  O     . PRO A 1 124 ? 19.679  13.529  21.049  1.000 37.694  0 124 PRO A O     1 ? 
ATOM   988  C  CB    . PRO A 1 124 ? 21.665  15.651  21.585  1.000 41.977  0 124 PRO A CB    1 ? 
ATOM   989  C  CG    . PRO A 1 124 ? 21.246  17.108  21.450  1.000 44.213  0 124 PRO A CG    1 ? 
ATOM   990  C  CD    . PRO A 1 124 ? 20.051  17.091  20.517  1.000 42.711  0 124 PRO A CD    1 ? 
ATOM   991  N  N     . GLY A 1 125 ? 21.162  12.685  19.553  1.000 35.723  0 125 GLY A N     1 ? 
ATOM   992  C  CA    . GLY A 1 125 ? 20.811  11.255  19.628  1.000 34.759  0 125 GLY A CA    1 ? 
ATOM   993  C  C     . GLY A 1 125 ? 19.767  10.840  18.603  1.000 31.428  0 125 GLY A C     1 ? 
ATOM   994  O  O     . GLY A 1 125 ? 19.486  9.624   18.524  1.000 30.638  0 125 GLY A O     1 ? 
ATOM   995  N  N     . TYR A 1 126 ? 19.202  11.781  17.843  1.000 29.316  0 126 TYR A N     1 ? 
ATOM   996  C  CA    . TYR A 1 126 ? 18.149  11.467  16.840  1.000 30.057  0 126 TYR A CA    1 ? 
ATOM   997  C  C     . TYR A 1 126 ? 18.034  12.578  15.801  1.000 27.907  0 126 TYR A C     1 ? 
ATOM   998  O  O     . TYR A 1 126 ? 18.494  13.711  16.062  1.000 28.830  0 126 TYR A O     1 ? 
ATOM   999  C  CB    . TYR A 1 126 ? 16.810  11.201  17.536  1.000 31.462  0 126 TYR A CB    1 ? 
ATOM   1000 C  CG    . TYR A 1 126 ? 16.135  12.383  18.182  1.000 31.877  0 126 TYR A CG    1 ? 
ATOM   1001 C  CD1   . TYR A 1 126 ? 16.336  12.693  19.518  1.000 33.013  0 126 TYR A CD1   1 ? 
ATOM   1002 C  CD2   . TYR A 1 126 ? 15.248  13.174  17.464  1.000 35.284  0 126 TYR A CD2   1 ? 
ATOM   1003 C  CE1   . TYR A 1 126 ? 15.683  13.766  20.116  1.000 34.886  0 126 TYR A CE1   1 ? 
ATOM   1004 C  CE2   . TYR A 1 126 ? 14.581  14.245  18.048  1.000 34.427  0 126 TYR A CE2   1 ? 
ATOM   1005 C  CZ    . TYR A 1 126 ? 14.801  14.547  19.381  1.000 36.408  0 126 TYR A CZ    1 ? 
ATOM   1006 O  OH    . TYR A 1 126 ? 14.121  15.587  19.951  1.000 37.727  0 126 TYR A OH    1 ? 
ATOM   1007 N  N     . HIS A 1 127 ? 17.466  12.233  14.645  1.000 29.001  0 127 HIS A N     1 ? 
ATOM   1008 C  CA    . HIS A 1 127 ? 17.060  13.171  13.557  1.000 27.138  0 127 HIS A CA    1 ? 
ATOM   1009 C  C     . HIS A 1 127 ? 15.615  12.859  13.149  1.000 27.976  0 127 HIS A C     1 ? 
ATOM   1010 O  O     . HIS A 1 127 ? 15.211  11.676  13.191  1.000 25.964  0 127 HIS A O     1 ? 
ATOM   1011 C  CB    . HIS A 1 127 ? 18.046  13.122  12.380  1.000 28.199  0 127 HIS A CB    1 ? 
ATOM   1012 C  CG    . HIS A 1 127 ? 18.137  11.792  11.691  1.000 30.876  0 127 HIS A CG    1 ? 
ATOM   1013 N  ND1   . HIS A 1 127 ? 19.117  10.859  12.006  1.000 27.216  0 127 HIS A ND1   1 ? 
ATOM   1014 C  CD2   . HIS A 1 127 ? 17.358  11.218  10.739  1.000 27.918  0 127 HIS A CD2   1 ? 
ATOM   1015 C  CE1   . HIS A 1 127 ? 18.944  9.781   11.271  1.000 28.408  0 127 HIS A CE1   1 ? 
ATOM   1016 N  NE2   . HIS A 1 127 ? 17.868  9.976   10.483  1.000 30.578  0 127 HIS A NE2   1 ? 
ATOM   1017 N  N     . VAL A 1 128 ? 14.835  13.886  12.843  1.000 27.467  0 128 VAL A N     1 ? 
ATOM   1018 C  CA    . VAL A 1 128 ? 13.504  13.711  12.208  1.000 26.170  0 128 VAL A CA    1 ? 
ATOM   1019 C  C     . VAL A 1 128 ? 13.641  13.995  10.716  1.000 25.005  0 128 VAL A C     1 ? 
ATOM   1020 O  O     . VAL A 1 128 ? 14.106  15.097  10.386  1.000 26.572  0 128 VAL A O     1 ? 
ATOM   1021 C  CB    . VAL A 1 128 ? 12.465  14.629  12.849  1.000 27.700  0 128 VAL A CB    1 ? 
ATOM   1022 C  CG1   . VAL A 1 128 ? 11.069  14.284  12.367  1.000 28.535  0 128 VAL A CG1   1 ? 
ATOM   1023 C  CG2   . VAL A 1 128 ? 12.564  14.564  14.363  1.000 29.319  0 128 VAL A CG2   1 ? 
ATOM   1024 N  N     . ASP A 1 129 ? 13.240  13.033  9.882   1.000 22.878  0 129 ASP A N     1 ? 
ATOM   1025 C  CA    . ASP A 1 129 ? 13.158  13.145  8.404   1.000 23.233  0 129 ASP A CA    1 ? 
ATOM   1026 C  C     . ASP A 1 129 ? 11.709  13.487  8.036   1.000 23.587  0 129 ASP A C     1 ? 
ATOM   1027 O  O     . ASP A 1 129 ? 10.823  12.622  8.170   1.000 23.663  0 129 ASP A O     1 ? 
ATOM   1028 C  CB    . ASP A 1 129 ? 13.636  11.862  7.720   1.000 23.007  0 129 ASP A CB    1 ? 
ATOM   1029 C  CG    . ASP A 1 129 ? 15.104  11.544  7.967   1.000 24.412  0 129 ASP A CG    1 ? 
ATOM   1030 O  OD1   . ASP A 1 129 ? 15.830  12.440  8.478   1.000 28.580  0 129 ASP A OD1   1 ? 
ATOM   1031 O  OD2   . ASP A 1 129 ? 15.523  10.385  7.662   1.000 27.746  0 129 ASP A OD2   1 ? 
ATOM   1032 N  N     . LEU A 1 130 ? 11.477  14.718  7.607   1.000 24.896  0 130 LEU A N     1 ? 
ATOM   1033 C  CA    . LEU A 1 130 ? 10.146  15.185  7.157   1.000 24.413  0 130 LEU A CA    1 ? 
ATOM   1034 C  C     . LEU A 1 130 ? 10.040  14.988  5.644   1.000 22.691  0 130 LEU A C     1 ? 
ATOM   1035 O  O     . LEU A 1 130 ? 10.696  15.745  4.893   1.000 21.788  0 130 LEU A O     1 ? 
ATOM   1036 C  CB    . LEU A 1 130 ? 9.985   16.643  7.563   1.000 27.043  0 130 LEU A CB    1 ? 
ATOM   1037 C  CG    . LEU A 1 130 ? 10.027  16.885  9.067   1.000 29.124  0 130 LEU A CG    1 ? 
ATOM   1038 C  CD1   . LEU A 1 130 ? 11.122  17.878  9.433   1.000 32.520  0 130 LEU A CD1   1 ? 
ATOM   1039 C  CD2   . LEU A 1 130 ? 8.674   17.358  9.568   1.000 31.943  0 130 LEU A CD2   1 ? 
ATOM   1040 N  N     . ALA A 1 131 ? 9.267   13.983  5.227   1.000 21.509  0 131 ALA A N     1 ? 
ATOM   1041 C  CA    . ALA A 1 131 ? 8.818   13.789  3.829   1.000 21.982  0 131 ALA A CA    1 ? 
ATOM   1042 C  C     . ALA A 1 131 ? 7.738   14.822  3.555   1.000 22.505  0 131 ALA A C     1 ? 
ATOM   1043 O  O     . ALA A 1 131 ? 6.788   14.930  4.389   1.000 26.055  0 131 ALA A O     1 ? 
ATOM   1044 C  CB    . ALA A 1 131 ? 8.295   12.389  3.637   1.000 22.483  0 131 ALA A CB    1 ? 
ATOM   1045 N  N     . VAL A 1 132 ? 7.905   15.599  2.494   1.000 22.338  0 132 VAL A N     1 ? 
ATOM   1046 C  CA    . VAL A 1 132 ? 7.036   16.775  2.204   1.000 21.569  0 132 VAL A CA    1 ? 
ATOM   1047 C  C     . VAL A 1 132 ? 6.210   16.485  0.960   1.000 22.676  0 132 VAL A C     1 ? 
ATOM   1048 O  O     . VAL A 1 132 ? 6.810   16.276  -0.129  1.000 22.923  0 132 VAL A O     1 ? 
ATOM   1049 C  CB    . VAL A 1 132 ? 7.854   18.075  2.060   1.000 20.973  0 132 VAL A CB    1 ? 
ATOM   1050 C  CG1   . VAL A 1 132 ? 6.963   19.275  1.811   1.000 20.968  0 132 VAL A CG1   1 ? 
ATOM   1051 C  CG2   . VAL A 1 132 ? 8.733   18.315  3.267   1.000 20.011  0 132 VAL A CG2   1 ? 
ATOM   1052 N  N     . TYR A 1 133 ? 4.892   16.564  1.106   1.000 20.733  0 133 TYR A N     1 ? 
ATOM   1053 C  CA    . TYR A 1 133 ? 3.918   16.176  0.067   1.000 21.910  0 133 TYR A CA    1 ? 
ATOM   1054 C  C     . TYR A 1 133 ? 3.003   17.356  -0.242  1.000 22.321  0 133 TYR A C     1 ? 
ATOM   1055 O  O     . TYR A 1 133 ? 2.796   18.203  0.659   1.000 21.915  0 133 TYR A O     1 ? 
ATOM   1056 C  CB    . TYR A 1 133 ? 3.087   14.980  0.528   1.000 20.940  0 133 TYR A CB    1 ? 
ATOM   1057 C  CG    . TYR A 1 133 ? 3.891   13.784  0.963   1.000 21.480  0 133 TYR A CG    1 ? 
ATOM   1058 C  CD1   . TYR A 1 133 ? 4.326   13.662  2.274   1.000 23.175  0 133 TYR A CD1   1 ? 
ATOM   1059 C  CD2   . TYR A 1 133 ? 4.157   12.740  0.096   1.000 20.688  0 133 TYR A CD2   1 ? 
ATOM   1060 C  CE1   . TYR A 1 133 ? 5.018   12.542  2.707   1.000 23.601  0 133 TYR A CE1   1 ? 
ATOM   1061 C  CE2   . TYR A 1 133 ? 4.859   11.616  0.511   1.000 21.141  0 133 TYR A CE2   1 ? 
ATOM   1062 C  CZ    . TYR A 1 133 ? 5.300   11.517  1.819   1.000 21.194  0 133 TYR A CZ    1 ? 
ATOM   1063 O  OH    . TYR A 1 133 ? 5.977   10.410  2.266   1.000 18.827  0 133 TYR A OH    1 ? 
ATOM   1064 N  N     . ALA A 1 134 ? 2.490   17.384  -1.469  1.000 22.151  0 134 ALA A N     1 ? 
ATOM   1065 C  CA    . ALA A 1 134 ? 1.373   18.254  -1.901  1.000 24.008  0 134 ALA A CA    1 ? 
ATOM   1066 C  C     . ALA A 1 134 ? 0.041   17.569  -1.574  1.000 24.881  0 134 ALA A C     1 ? 
ATOM   1067 O  O     . ALA A 1 134 ? 0.013   16.325  -1.480  1.000 24.547  0 134 ALA A O     1 ? 
ATOM   1068 C  CB    . ALA A 1 134 ? 1.459   18.547  -3.374  1.000 22.265  0 134 ALA A CB    1 ? 
ATOM   1069 N  N     . ASP A 1 135 ? -1.019  18.372  -1.459  1.000 26.053  0 135 ASP A N     1 ? 
ATOM   1070 C  CA    . ASP A 1 135 ? -2.412  17.908  -1.232  1.000 27.124  0 135 ASP A CA    1 ? 
ATOM   1071 C  C     . ASP A 1 135 ? -2.891  17.143  -2.457  1.000 28.699  0 135 ASP A C     1 ? 
ATOM   1072 O  O     . ASP A 1 135 ? -2.947  17.708  -3.545  1.000 30.712  0 135 ASP A O     1 ? 
ATOM   1073 C  CB    . ASP A 1 135 ? -3.340  19.085  -0.931  1.000 28.590  0 135 ASP A CB    1 ? 
ATOM   1074 C  CG    . ASP A 1 135 ? -4.546  18.677  -0.107  1.000 30.029  0 135 ASP A CG    1 ? 
ATOM   1075 O  OD1   . ASP A 1 135 ? -5.146  17.659  -0.457  1.000 31.413  0 135 ASP A OD1   1 ? 
ATOM   1076 O  OD2   . ASP A 1 135 ? -4.828  19.353  0.920   1.000 37.452  0 135 ASP A OD2   1 ? 
ATOM   1077 N  N     . PRO A 1 136 ? -3.245  15.840  -2.337  1.000 28.267  0 136 PRO A N     1 ? 
ATOM   1078 C  CA    . PRO A 1 136 ? -3.761  15.076  -3.476  1.000 30.020  0 136 PRO A CA    1 ? 
ATOM   1079 C  C     . PRO A 1 136 ? -5.068  15.649  -4.051  1.000 31.994  0 136 PRO A C     1 ? 
ATOM   1080 O  O     . PRO A 1 136 ? -5.237  15.619  -5.266  1.000 30.325  0 136 PRO A O     1 ? 
ATOM   1081 C  CB    . PRO A 1 136 ? -3.988  13.671  -2.904  1.000 29.065  0 136 PRO A CB    1 ? 
ATOM   1082 C  CG    . PRO A 1 136 ? -3.094  13.605  -1.683  1.000 28.066  0 136 PRO A CG    1 ? 
ATOM   1083 C  CD    . PRO A 1 136 ? -3.098  15.014  -1.133  1.000 29.490  0 136 PRO A CD    1 ? 
ATOM   1084 N  N     . GLU A 1 137 ? -5.922  16.178  -3.168  1.000 37.743  0 137 GLU A N     1 ? 
ATOM   1085 C  CA    . GLU A 1 137 ? -7.187  16.893  -3.495  1.000 43.494  0 137 GLU A CA    1 ? 
ATOM   1086 C  C     . GLU A 1 137 ? -6.893  18.059  -4.442  1.000 41.640  0 137 GLU A C     1 ? 
ATOM   1087 O  O     . GLU A 1 137 ? -7.729  18.305  -5.327  1.000 40.798  0 137 GLU A O     1 ? 
ATOM   1088 C  CB    . GLU A 1 137 ? -7.874  17.415  -2.225  1.000 48.795  0 137 GLU A CB    1 ? 
ATOM   1089 C  CG    . GLU A 1 137 ? -8.940  16.479  -1.657  1.000 55.318  0 137 GLU A CG    1 ? 
ATOM   1090 C  CD    . GLU A 1 137 ? -10.324 16.580  -2.292  1.000 60.897  0 137 GLU A CD    1 ? 
ATOM   1091 O  OE1   . GLU A 1 137 ? -11.234 17.178  -1.657  1.000 62.645  0 137 GLU A OE1   1 ? 
ATOM   1092 O  OE2   . GLU A 1 137 ? -10.506 16.040  -3.412  1.000 63.680  0 137 GLU A OE2   1 ? 
ATOM   1093 N  N     . LEU A 1 138 ? -5.764  18.756  -4.261  1.000 38.437  0 138 LEU A N     1 ? 
ATOM   1094 C  CA    . LEU A 1 138 ? -5.408  19.945  -5.079  1.000 35.556  0 138 LEU A CA    1 ? 
ATOM   1095 C  C     . LEU A 1 138 ? -4.468  19.536  -6.210  1.000 38.330  0 138 LEU A C     1 ? 
ATOM   1096 O  O     . LEU A 1 138 ? -4.168  20.401  -7.045  1.000 39.271  0 138 LEU A O     1 ? 
ATOM   1097 C  CB    . LEU A 1 138 ? -4.758  21.011  -4.197  1.000 37.012  0 138 LEU A CB    1 ? 
ATOM   1098 C  CG    . LEU A 1 138 ? -5.665  21.651  -3.147  1.000 38.159  0 138 LEU A CG    1 ? 
ATOM   1099 C  CD1   . LEU A 1 138 ? -4.860  22.461  -2.148  1.000 38.678  0 138 LEU A CD1   1 ? 
ATOM   1100 C  CD2   . LEU A 1 138 ? -6.715  22.533  -3.798  1.000 40.004  0 138 LEU A CD2   1 ? 
ATOM   1101 N  N     . SER A 1 139 ? -4.016  18.279  -6.248  1.000 37.820  0 139 SER A N     1 ? 
ATOM   1102 C  CA    . SER A 1 139 ? -2.895  17.837  -7.124  1.000 38.101  0 139 SER A CA    1 ? 
ATOM   1103 C  C     . SER A 1 139 ? -3.332  16.707  -8.063  1.000 37.905  0 139 SER A C     1 ? 
ATOM   1104 O  O     . SER A 1 139 ? -2.421  16.110  -8.686  1.000 37.684  0 139 SER A O     1 ? 
ATOM   1105 C  CB    . SER A 1 139 ? -1.677  17.422  -6.310  1.000 34.994  0 139 SER A CB    1 ? 
ATOM   1106 O  OG    . SER A 1 139 ? -1.144  18.520  -5.589  1.000 31.965  0 139 SER A OG    1 ? 
ATOM   1107 N  N     . GLY A 1 140 ? -4.641  16.411  -8.150  1.000 36.900  0 140 GLY A N     1 ? 
ATOM   1108 C  CA    . GLY A 1 140 ? -5.206  15.436  -9.112  1.000 36.205  0 140 GLY A CA    1 ? 
ATOM   1109 C  C     . GLY A 1 140 ? -5.405  14.043  -8.520  1.000 36.045  0 140 GLY A C     1 ? 
ATOM   1110 O  O     . GLY A 1 140 ? -5.390  13.072  -9.293  1.000 38.978  0 140 GLY A O     1 ? 
ATOM   1111 N  N     . GLY A 1 141 ? -5.585  13.930  -7.201  1.000 35.516  0 141 GLY A N     1 ? 
ATOM   1112 C  CA    . GLY A 1 141 ? -5.858  12.647  -6.524  1.000 39.942  0 141 GLY A CA    1 ? 
ATOM   1113 C  C     . GLY A 1 141 ? -4.598  11.907  -6.081  1.000 40.842  0 141 GLY A C     1 ? 
ATOM   1114 O  O     . GLY A 1 141 ? -4.674  11.227  -5.050  1.000 49.093  0 141 GLY A O     1 ? 
ATOM   1115 N  N     . THR A 1 142 ? -3.474  12.020  -6.810  1.000 45.484  0 142 THR A N     1 ? 
ATOM   1116 C  CA    . THR A 1 142 ? -2.178  11.359  -6.458  1.000 41.874  0 142 THR A CA    1 ? 
ATOM   1117 C  C     . THR A 1 142 ? -1.455  12.134  -5.349  1.000 36.029  0 142 THR A C     1 ? 
ATOM   1118 O  O     . THR A 1 142 ? -1.422  13.383  -5.409  1.000 35.917  0 142 THR A O     1 ? 
ATOM   1119 C  CB    . THR A 1 142 ? -1.208  11.243  -7.639  1.000 42.143  0 142 THR A CB    1 ? 
ATOM   1120 O  OG1   . THR A 1 142 ? -1.071  12.549  -8.190  1.000 45.398  0 142 THR A OG1   1 ? 
ATOM   1121 C  CG2   . THR A 1 142 ? -1.650  10.257  -8.697  1.000 45.984  0 142 THR A CG2   1 ? 
ATOM   1122 N  N     . LEU A 1 143 ? -0.848  11.387  -4.423  1.000 30.941  0 143 LEU A N     1 ? 
ATOM   1123 C  CA    . LEU A 1 143 ? 0.044   11.871  -3.336  1.000 28.260  0 143 LEU A CA    1 ? 
ATOM   1124 C  C     . LEU A 1 143 ? 1.486   11.865  -3.841  1.000 25.916  0 143 LEU A C     1 ? 
ATOM   1125 O  O     . LEU A 1 143 ? 2.032   10.734  -4.066  1.000 25.284  0 143 LEU A O     1 ? 
ATOM   1126 C  CB    . LEU A 1 143 ? -0.129  10.942  -2.130  1.000 26.388  0 143 LEU A CB    1 ? 
ATOM   1127 C  CG    . LEU A 1 143 ? 0.686   11.261  -0.878  1.000 26.279  0 143 LEU A CG    1 ? 
ATOM   1128 C  CD1   . LEU A 1 143 ? 0.380   12.656  -0.360  1.000 25.430  0 143 LEU A CD1   1 ? 
ATOM   1129 C  CD2   . LEU A 1 143 ? 0.422   10.215  0.216   1.000 27.189  0 143 LEU A CD2   1 ? 
ATOM   1130 N  N     . CYS A 1 144 ? 2.087   13.061  -3.959  1.000 25.736  0 144 CYS A N     1 ? 
ATOM   1131 C  CA    . CYS A 1 144 ? 3.438   13.263  -4.546  1.000 25.204  0 144 CYS A CA    1 ? 
ATOM   1132 C  C     . CYS A 1 144 ? 4.386   13.884  -3.512  1.000 25.491  0 144 CYS A C     1 ? 
ATOM   1133 O  O     . CYS A 1 144 ? 4.012   14.862  -2.797  1.000 24.394  0 144 CYS A O     1 ? 
ATOM   1134 C  CB    . CYS A 1 144 ? 3.405   14.143  -5.793  1.000 26.329  0 144 CYS A CB    1 ? 
ATOM   1135 S  SG    . CYS A 1 144 ? 2.384   13.500  -7.142  1.000 28.452  0 144 CYS A SG    1 ? 
ATOM   1136 N  N     . ILE A 1 145 ? 5.590   13.334  -3.454  1.000 24.300  0 145 ILE A N     1 ? 
ATOM   1137 C  CA    . ILE A 1 145 ? 6.657   13.730  -2.503  1.000 25.379  0 145 ILE A CA    1 ? 
ATOM   1138 C  C     . ILE A 1 145 ? 7.560   14.751  -3.232  1.000 24.082  0 145 ILE A C     1 ? 
ATOM   1139 O  O     . ILE A 1 145 ? 7.716   14.644  -4.458  1.000 24.700  0 145 ILE A O     1 ? 
ATOM   1140 C  CB    . ILE A 1 145 ? 7.387   12.461  -1.983  1.000 25.932  0 145 ILE A CB    1 ? 
ATOM   1141 C  CG1   . ILE A 1 145 ? 8.376   12.764  -0.846  1.000 27.853  0 145 ILE A CG1   1 ? 
ATOM   1142 C  CG2   . ILE A 1 145 ? 8.066   11.689  -3.091  1.000 24.052  0 145 ILE A CG2   1 ? 
ATOM   1143 C  CD1   . ILE A 1 145 ? 8.991   11.505  -0.211  1.000 26.919  0 145 ILE A CD1   1 ? 
ATOM   1144 N  N     . ALA A 1 146 ? 8.097   15.724  -2.511  1.000 23.500  0 146 ALA A N     1 ? 
ATOM   1145 C  CA    . ALA A 1 146 ? 8.990   16.779  -3.043  1.000 24.358  0 146 ALA A CA    1 ? 
ATOM   1146 C  C     . ALA A 1 146 ? 10.405  16.202  -3.209  1.000 27.197  0 146 ALA A C     1 ? 
ATOM   1147 O  O     . ALA A 1 146 ? 11.112  16.114  -2.186  1.000 26.037  0 146 ALA A O     1 ? 
ATOM   1148 C  CB    . ALA A 1 146 ? 8.986   17.971  -2.112  1.000 23.748  0 146 ALA A CB    1 ? 
ATOM   1149 N  N     . LYS A 1 147 ? 10.804  15.843  -4.444  1.000 28.497  0 147 LYS A N     1 ? 
ATOM   1150 C  CA    . LYS A 1 147 ? 12.176  15.354  -4.766  1.000 29.620  0 147 LYS A CA    1 ? 
ATOM   1151 C  C     . LYS A 1 147 ? 13.010  16.510  -5.318  1.000 32.034  0 147 LYS A C     1 ? 
ATOM   1152 O  O     . LYS A 1 147 ? 12.456  17.336  -6.102  1.000 29.877  0 147 LYS A O     1 ? 
ATOM   1153 C  CB    . LYS A 1 147 ? 12.138  14.179  -5.748  1.000 31.730  0 147 LYS A CB    1 ? 
ATOM   1154 C  CG    . LYS A 1 147 ? 11.283  12.994  -5.295  1.000 33.821  0 147 LYS A CG    1 ? 
ATOM   1155 C  CD    . LYS A 1 147 ? 11.780  12.288  -4.043  1.000 35.030  0 147 LYS A CD    1 ? 
ATOM   1156 C  CE    . LYS A 1 147 ? 12.491  10.988  -4.340  1.000 39.629  0 147 LYS A CE    1 ? 
ATOM   1157 N  NZ    . LYS A 1 147 ? 13.616  11.200  -5.278  1.000 43.864  0 147 LYS A NZ    1 ? 
ATOM   1158 N  N     . GLY A 1 148 ? 14.270  16.583  -4.868  1.000 31.505  0 148 GLY A N     1 ? 
ATOM   1159 C  CA    . GLY A 1 148 ? 15.296  17.525  -5.353  1.000 30.871  0 148 GLY A CA    1 ? 
ATOM   1160 C  C     . GLY A 1 148 ? 16.074  18.168  -4.217  1.000 31.894  0 148 GLY A C     1 ? 
ATOM   1161 O  O     . GLY A 1 148 ? 15.477  18.372  -3.118  1.000 27.081  0 148 GLY A O     1 ? 
ATOM   1162 N  N     . LYS A 1 149 ? 17.345  18.509  -4.480  1.000 32.805  0 149 LYS A N     1 ? 
ATOM   1163 C  CA    . LYS A 1 149 ? 18.207  19.325  -3.584  1.000 38.885  0 149 LYS A CA    1 ? 
ATOM   1164 C  C     . LYS A 1 149 ? 18.305  20.739  -4.155  1.000 40.604  0 149 LYS A C     1 ? 
ATOM   1165 O  O     . LYS A 1 149 ? 17.996  20.903  -5.349  1.000 41.338  0 149 LYS A O     1 ? 
ATOM   1166 C  CB    . LYS A 1 149 ? 19.601  18.709  -3.441  1.000 41.761  0 149 LYS A CB    1 ? 
ATOM   1167 C  CG    . LYS A 1 149 ? 19.658  17.374  -2.711  1.000 45.138  0 149 LYS A CG    1 ? 
ATOM   1168 C  CD    . LYS A 1 149 ? 21.064  16.848  -2.552  1.000 46.566  0 149 LYS A CD    1 ? 
ATOM   1169 C  CE    . LYS A 1 149 ? 21.247  15.449  -3.107  1.000 52.060  0 149 LYS A CE    1 ? 
ATOM   1170 N  NZ    . LYS A 1 149 ? 21.214  15.413  -4.588  1.000 54.322  0 149 LYS A NZ    1 ? 
ATOM   1171 N  N     . GLU A 1 150 ? 18.701  21.712  -3.324  1.000 42.664  0 150 GLU A N     1 ? 
ATOM   1172 C  CA    . GLU A 1 150 ? 18.974  23.104  -3.764  1.000 47.036  0 150 GLU A CA    1 ? 
ATOM   1173 C  C     . GLU A 1 150 ? 19.962  23.024  -4.922  1.000 52.481  0 150 GLU A C     1 ? 
ATOM   1174 O  O     . GLU A 1 150 ? 19.608  23.451  -6.035  1.000 59.386  0 150 GLU A O     1 ? 
ATOM   1175 C  CB    . GLU A 1 150 ? 19.553  23.951  -2.634  1.000 47.122  0 150 GLU A CB    1 ? 
ATOM   1176 C  CG    . GLU A 1 150 ? 18.859  23.756  -1.306  1.000 46.892  0 150 GLU A CG    1 ? 
ATOM   1177 C  CD    . GLU A 1 150 ? 18.940  24.970  -0.403  1.000 47.267  0 150 GLU A CD    1 ? 
ATOM   1178 O  OE1   . GLU A 1 150 ? 18.571  26.059  -0.857  1.000 50.363  0 150 GLU A OE1   1 ? 
ATOM   1179 O  OE2   . GLU A 1 150 ? 19.392  24.823  0.740   1.000 50.356  0 150 GLU A OE2   1 ? 
ATOM   1180 N  N     . ASN A 1 151 ? 21.125  22.428  -4.657  1.000 58.049  0 151 ASN A N     1 ? 
ATOM   1181 C  CA    . ASN A 1 151 ? 22.146  22.071  -5.674  1.000 67.521  0 151 ASN A CA    1 ? 
ATOM   1182 C  C     . ASN A 1 151 ? 21.661  20.805  -6.395  1.000 69.714  0 151 ASN A C     1 ? 
ATOM   1183 O  O     . ASN A 1 151 ? 22.159  19.693  -6.057  1.000 69.837  0 151 ASN A O     1 ? 
ATOM   1184 C  CB    . ASN A 1 151 ? 23.532  21.925  -5.032  1.000 74.781  0 151 ASN A CB    1 ? 
ATOM   1185 C  CG    . ASN A 1 151 ? 24.673  22.092  -6.018  1.000 84.792  0 151 ASN A CG    1 ? 
ATOM   1186 O  OD1   . ASN A 1 151 ? 24.570  21.667  -7.169  1.000 91.828  0 151 ASN A OD1   1 ? 
ATOM   1187 N  ND2   . ASN A 1 151 ? 25.769  22.701  -5.578  1.000 79.363  0 151 ASN A ND2   1 ? 
ATOM   1188 N  N     . SER A 1 152 ? 20.682  20.971  -7.300  1.000 62.009  0 152 SER A N     1 ? 
ATOM   1189 C  CA    . SER A 1 152 ? 20.153  19.931  -8.229  1.000 59.452  0 152 SER A CA    1 ? 
ATOM   1190 C  C     . SER A 1 152 ? 19.397  20.597  -9.390  1.000 55.756  0 152 SER A C     1 ? 
ATOM   1191 O  O     . SER A 1 152 ? 18.608  21.546  -9.129  1.000 52.856  0 152 SER A O     1 ? 
ATOM   1192 C  CB    . SER A 1 152 ? 19.275  18.939  -7.505  1.000 62.288  0 152 SER A CB    1 ? 
ATOM   1193 O  OG    . SER A 1 152 ? 17.923  19.372  -7.484  1.000 64.649  0 152 SER A OG    1 ? 
ATOM   1194 N  N     . GLY A 1 153 ? 19.615  20.108  -10.619 1.000 54.735  0 153 GLY A N     1 ? 
ATOM   1195 C  CA    . GLY A 1 153 ? 19.075  20.687  -11.868 1.000 51.154  0 153 GLY A CA    1 ? 
ATOM   1196 C  C     . GLY A 1 153 ? 17.582  20.455  -12.029 1.000 50.036  0 153 GLY A C     1 ? 
ATOM   1197 O  O     . GLY A 1 153 ? 17.010  19.662  -11.252 1.000 53.030  0 153 GLY A O     1 ? 
ATOM   1198 N  N     . ASP A 1 154 ? 16.969  21.119  -13.013 1.000 49.232  0 154 ASP A N     1 ? 
ATOM   1199 C  CA    . ASP A 1 154 ? 15.503  21.076  -13.280 1.000 50.943  0 154 ASP A CA    1 ? 
ATOM   1200 C  C     . ASP A 1 154 ? 15.003  19.628  -13.346 1.000 52.602  0 154 ASP A C     1 ? 
ATOM   1201 O  O     . ASP A 1 154 ? 13.936  19.342  -12.759 1.000 51.705  0 154 ASP A O     1 ? 
ATOM   1202 C  CB    . ASP A 1 154 ? 15.136  21.807  -14.574 1.000 52.557  0 154 ASP A CB    1 ? 
ATOM   1203 C  CG    . ASP A 1 154 ? 14.533  23.179  -14.335 1.000 57.106  0 154 ASP A CG    1 ? 
ATOM   1204 O  OD1   . ASP A 1 154 ? 15.287  24.078  -13.903 1.000 54.514  0 154 ASP A OD1   1 ? 
ATOM   1205 O  OD2   . ASP A 1 154 ? 13.301  23.327  -14.547 1.000 66.921  0 154 ASP A OD2   1 ? 
ATOM   1206 N  N     . GLU A 1 155 ? 15.721  18.761  -14.062 1.000 52.705  0 155 GLU A N     1 ? 
ATOM   1207 C  CA    . GLU A 1 155 ? 15.318  17.346  -14.287 1.000 56.197  0 155 GLU A CA    1 ? 
ATOM   1208 C  C     . GLU A 1 155 ? 15.190  16.624  -12.941 1.000 53.114  0 155 GLU A C     1 ? 
ATOM   1209 O  O     . GLU A 1 155 ? 14.357  15.697  -12.866 1.000 55.667  0 155 GLU A O     1 ? 
ATOM   1210 C  CB    . GLU A 1 155 ? 16.312  16.624  -15.199 1.000 60.353  0 155 GLU A CB    1 ? 
ATOM   1211 C  CG    . GLU A 1 155 ? 17.762  16.754  -14.761 1.000 64.756  0 155 GLU A CG    1 ? 
ATOM   1212 C  CD    . GLU A 1 155 ? 18.687  15.708  -15.359 1.000 71.531  0 155 GLU A CD    1 ? 
ATOM   1213 O  OE1   . GLU A 1 155 ? 18.180  14.642  -15.794 1.000 72.427  0 155 GLU A OE1   1 ? 
ATOM   1214 O  OE2   . GLU A 1 155 ? 19.913  15.956  -15.384 1.000 70.360  0 155 GLU A OE2   1 ? 
ATOM   1215 N  N     . HIS A 1 156 ? 15.968  17.032  -11.928 1.000 48.822  0 156 HIS A N     1 ? 
ATOM   1216 C  CA    . HIS A 1 156 ? 16.072  16.322  -10.627 1.000 50.759  0 156 HIS A CA    1 ? 
ATOM   1217 C  C     . HIS A 1 156 ? 15.250  17.022  -9.546  1.000 46.876  0 156 HIS A C     1 ? 
ATOM   1218 O  O     . HIS A 1 156 ? 15.316  16.564  -8.399  1.000 46.338  0 156 HIS A O     1 ? 
ATOM   1219 C  CB    . HIS A 1 156 ? 17.539  16.127  -10.232 1.000 54.059  0 156 HIS A CB    1 ? 
ATOM   1220 C  CG    . HIS A 1 156 ? 18.272  15.321  -11.244 1.000 58.354  0 156 HIS A CG    1 ? 
ATOM   1221 N  ND1   . HIS A 1 156 ? 17.709  14.199  -11.822 1.000 62.178  0 156 HIS A ND1   1 ? 
ATOM   1222 C  CD2   . HIS A 1 156 ? 19.482  15.483  -11.815 1.000 60.338  0 156 HIS A CD2   1 ? 
ATOM   1223 C  CE1   . HIS A 1 156 ? 18.549  13.688  -12.694 1.000 65.203  0 156 HIS A CE1   1 ? 
ATOM   1224 N  NE2   . HIS A 1 156 ? 19.648  14.457  -12.705 1.000 66.395  0 156 HIS A NE2   1 ? 
ATOM   1225 N  N     . ARG A 1 157 ? 14.467  18.043  -9.901  1.000 45.360  0 157 ARG A N     1 ? 
ATOM   1226 C  CA    . ARG A 1 157 ? 13.453  18.621  -8.980  1.000 45.131  0 157 ARG A CA    1 ? 
ATOM   1227 C  C     . ARG A 1 157 ? 12.059  18.314  -9.537  1.000 41.696  0 157 ARG A C     1 ? 
ATOM   1228 O  O     . ARG A 1 157 ? 11.648  18.956  -10.522 1.000 43.847  0 157 ARG A O     1 ? 
ATOM   1229 C  CB    . ARG A 1 157 ? 13.710  20.107  -8.716  1.000 49.618  0 157 ARG A CB    1 ? 
ATOM   1230 C  CG    . ARG A 1 157 ? 13.642  21.009  -9.935  1.000 55.301  0 157 ARG A CG    1 ? 
ATOM   1231 C  CD    . ARG A 1 157 ? 13.812  22.454  -9.515  1.000 57.796  0 157 ARG A CD    1 ? 
ATOM   1232 N  NE    . ARG A 1 157 ? 15.076  22.634  -8.834  1.000 59.433  0 157 ARG A NE    1 ? 
ATOM   1233 C  CZ    . ARG A 1 157 ? 15.466  23.750  -8.240  1.000 69.734  0 157 ARG A CZ    1 ? 
ATOM   1234 N  NH1   . ARG A 1 157 ? 14.676  24.811  -8.223  1.000 75.180  0 157 ARG A NH1   1 ? 
ATOM   1235 N  NH2   . ARG A 1 157 ? 16.654  23.800  -7.659  1.000 72.993  0 157 ARG A NH2   1 ? 
ATOM   1236 N  N     . LEU A 1 158 ? 11.381  17.334  -8.933  1.000 36.046  0 158 LEU A N     1 ? 
ATOM   1237 C  CA    . LEU A 1 158 ? 10.067  16.806  -9.386  1.000 33.453  0 158 LEU A CA    1 ? 
ATOM   1238 C  C     . LEU A 1 158 ? 9.195   16.456  -8.175  1.000 30.031  0 158 LEU A C     1 ? 
ATOM   1239 O  O     . LEU A 1 158 ? 9.735   16.332  -7.059  1.000 28.632  0 158 LEU A O     1 ? 
ATOM   1240 C  CB    . LEU A 1 158 ? 10.267  15.582  -10.290 1.000 34.338  0 158 LEU A CB    1 ? 
ATOM   1241 C  CG    . LEU A 1 158 ? 10.949  14.365  -9.661  1.000 35.638  0 158 LEU A CG    1 ? 
ATOM   1242 C  CD1   . LEU A 1 158 ? 10.522  13.082  -10.351 1.000 34.126  0 158 LEU A CD1   1 ? 
ATOM   1243 C  CD2   . LEU A 1 158 ? 12.456  14.502  -9.713  1.000 37.250  0 158 LEU A CD2   1 ? 
ATOM   1244 N  N     . TRP A 1 159 ? 7.889   16.382  -8.413  1.000 27.449  0 159 TRP A N     1 ? 
ATOM   1245 C  CA    . TRP A 1 159 ? 6.858   15.798  -7.528  1.000 27.521  0 159 TRP A CA    1 ? 
ATOM   1246 C  C     . TRP A 1 159 ? 6.616   14.353  -7.955  1.000 29.346  0 159 TRP A C     1 ? 
ATOM   1247 O  O     . TRP A 1 159 ? 6.021   14.158  -9.020  1.000 33.370  0 159 TRP A O     1 ? 
ATOM   1248 C  CB    . TRP A 1 159 ? 5.562   16.607  -7.621  1.000 26.506  0 159 TRP A CB    1 ? 
ATOM   1249 C  CG    . TRP A 1 159 ? 5.652   17.992  -7.073  1.000 26.178  0 159 TRP A CG    1 ? 
ATOM   1250 C  CD1   . TRP A 1 159 ? 5.780   19.149  -7.789  1.000 23.096  0 159 TRP A CD1   1 ? 
ATOM   1251 C  CD2   . TRP A 1 159 ? 5.550   18.374  -5.690  1.000 26.090  0 159 TRP A CD2   1 ? 
ATOM   1252 N  NE1   . TRP A 1 159 ? 5.795   20.218  -6.945  1.000 24.436  0 159 TRP A NE1   1 ? 
ATOM   1253 C  CE2   . TRP A 1 159 ? 5.642   19.783  -5.651  1.000 25.774  0 159 TRP A CE2   1 ? 
ATOM   1254 C  CE3   . TRP A 1 159 ? 5.401   17.668  -4.490  1.000 26.483  0 159 TRP A CE3   1 ? 
ATOM   1255 C  CZ2   . TRP A 1 159 ? 5.594   20.500  -4.455  1.000 25.990  0 159 TRP A CZ2   1 ? 
ATOM   1256 C  CZ3   . TRP A 1 159 ? 5.344   18.372  -3.309  1.000 26.603  0 159 TRP A CZ3   1 ? 
ATOM   1257 C  CH2   . TRP A 1 159 ? 5.457   19.767  -3.291  1.000 28.161  0 159 TRP A CH2   1 ? 
ATOM   1258 N  N     . GLN A 1 160 ? 7.097   13.380  -7.193  1.000 26.176  0 160 GLN A N     1 ? 
ATOM   1259 C  CA    . GLN A 1 160 ? 7.038   11.960  -7.606  1.000 25.740  0 160 GLN A CA    1 ? 
ATOM   1260 C  C     . GLN A 1 160 ? 5.893   11.283  -6.866  1.000 25.462  0 160 GLN A C     1 ? 
ATOM   1261 O  O     . GLN A 1 160 ? 5.767   11.489  -5.630  1.000 22.372  0 160 GLN A O     1 ? 
ATOM   1262 C  CB    . GLN A 1 160 ? 8.340   11.235  -7.295  1.000 28.829  0 160 GLN A CB    1 ? 
ATOM   1263 C  CG    . GLN A 1 160 ? 8.310   9.768   -7.684  1.000 28.278  0 160 GLN A CG    1 ? 
ATOM   1264 C  CD    . GLN A 1 160 ? 9.652   9.145   -7.409  1.000 29.896  0 160 GLN A CD    1 ? 
ATOM   1265 O  OE1   . GLN A 1 160 ? 10.132  9.115   -6.281  1.000 30.393  0 160 GLN A OE1   1 ? 
ATOM   1266 N  NE2   . GLN A 1 160 ? 10.271  8.625   -8.450  1.000 36.022  0 160 GLN A NE2   1 ? 
ATOM   1267 N  N     . ILE A 1 161 ? 5.106   10.511  -7.605  1.000 25.796  0 161 ILE A N     1 ? 
ATOM   1268 C  CA    . ILE A 1 161 ? 4.046   9.614   -7.073  1.000 27.775  0 161 ILE A CA    1 ? 
ATOM   1269 C  C     . ILE A 1 161 ? 4.653   8.766   -5.940  1.000 26.413  0 161 ILE A C     1 ? 
ATOM   1270 O  O     . ILE A 1 161 ? 5.728   8.124   -6.148  1.000 21.307  0 161 ILE A O     1 ? 
ATOM   1271 C  CB    . ILE A 1 161 ? 3.477   8.751   -8.219  1.000 32.523  0 161 ILE A CB    1 ? 
ATOM   1272 C  CG1   . ILE A 1 161 ? 2.385   7.798   -7.731  1.000 34.109  0 161 ILE A CG1   1 ? 
ATOM   1273 C  CG2   . ILE A 1 161 ? 4.597   8.014   -8.949  1.000 33.914  0 161 ILE A CG2   1 ? 
ATOM   1274 C  CD1   . ILE A 1 161 ? 1.134   8.499   -7.276  1.000 37.790  0 161 ILE A CD1   1 ? 
ATOM   1275 N  N     . SER A 1 162 ? 4.003   8.805   -4.772  1.000 26.116  0 162 SER A N     1 ? 
ATOM   1276 C  CA    . SER A 1 162 ? 4.453   8.171   -3.508  1.000 23.388  0 162 SER A CA    1 ? 
ATOM   1277 C  C     . SER A 1 162 ? 3.273   7.400   -2.877  1.000 23.028  0 162 SER A C     1 ? 
ATOM   1278 O  O     . SER A 1 162 ? 2.115   7.798   -3.087  1.000 20.128  0 162 SER A O     1 ? 
ATOM   1279 C  CB    . SER A 1 162 ? 4.990   9.226   -2.589  1.000 22.379  0 162 SER A CB    1 ? 
ATOM   1280 O  OG    . SER A 1 162 ? 6.028   8.700   -1.788  1.000 25.150  0 162 SER A OG    1 ? 
ATOM   1281 N  N     . ASP A 1 163 ? 3.542   6.338   -2.123  1.000 20.756  0 163 ASP A N     1 ? 
ATOM   1282 C  CA    . ASP A 1 163 ? 2.470   5.545   -1.468  1.000 18.856  0 163 ASP A CA    1 ? 
ATOM   1283 C  C     . ASP A 1 163 ? 3.050   4.975   -0.180  1.000 20.109  0 163 ASP A C     1 ? 
ATOM   1284 O  O     . ASP A 1 163 ? 3.103   3.764   0.003   1.000 19.560  0 163 ASP A O     1 ? 
ATOM   1285 C  CB    . ASP A 1 163 ? 1.915   4.462   -2.398  1.000 17.875  0 163 ASP A CB    1 ? 
ATOM   1286 C  CG    . ASP A 1 163 ? 0.636   3.831   -1.860  1.000 18.896  0 163 ASP A CG    1 ? 
ATOM   1287 O  OD1   . ASP A 1 163 ? 0.103   4.373   -0.848  1.000 17.303  0 163 ASP A OD1   1 ? 
ATOM   1288 O  OD2   . ASP A 1 163 ? 0.184   2.798   -2.443  1.000 21.546  0 163 ASP A OD2   1 ? 
ATOM   1289 N  N     . PRO A 1 164 ? 3.556   5.833   0.725   1.000 20.133  0 164 PRO A N     1 ? 
ATOM   1290 C  CA    . PRO A 1 164 ? 4.061   5.363   2.013   1.000 21.036  0 164 PRO A CA    1 ? 
ATOM   1291 C  C     . PRO A 1 164 ? 3.007   4.571   2.810   1.000 22.047  0 164 PRO A C     1 ? 
ATOM   1292 O  O     . PRO A 1 164 ? 3.343   3.575   3.451   1.000 20.266  0 164 PRO A O     1 ? 
ATOM   1293 C  CB    . PRO A 1 164 ? 4.442   6.660   2.752   1.000 21.668  0 164 PRO A CB    1 ? 
ATOM   1294 C  CG    . PRO A 1 164 ? 3.662   7.762   2.041   1.000 21.409  0 164 PRO A CG    1 ? 
ATOM   1295 C  CD    . PRO A 1 164 ? 3.600   7.299   0.595   1.000 22.101  0 164 PRO A CD    1 ? 
ATOM   1296 N  N     . GLN A 1 165 ? 1.748   5.008   2.792   1.000 21.683  0 165 GLN A N     1 ? 
ATOM   1297 C  CA    . GLN A 1 165 ? 0.709   4.316   3.595   1.000 21.870  0 165 GLN A CA    1 ? 
ATOM   1298 C  C     . GLN A 1 165 ? 0.422   2.961   2.939   1.000 19.438  0 165 GLN A C     1 ? 
ATOM   1299 O  O     . GLN A 1 165 ? 0.139   1.996   3.676   1.000 19.816  0 165 GLN A O     1 ? 
ATOM   1300 C  CB    . GLN A 1 165 ? -0.478  5.256   3.789   1.000 25.095  0 165 GLN A CB    1 ? 
ATOM   1301 C  CG    . GLN A 1 165 ? -0.053  6.476   4.601   1.000 29.331  0 165 GLN A CG    1 ? 
ATOM   1302 C  CD    . GLN A 1 165 ? -1.192  7.305   5.134   1.000 31.833  0 165 GLN A CD    1 ? 
ATOM   1303 O  OE1   . GLN A 1 165 ? -1.452  7.356   6.345   1.000 33.264  0 165 GLN A OE1   1 ? 
ATOM   1304 N  NE2   . GLN A 1 165 ? -1.844  8.008   4.223   1.000 33.906  0 165 GLN A NE2   1 ? 
ATOM   1305 N  N     . GLY A 1 166 ? 0.465   2.899   1.612   1.000 16.171  0 166 GLY A N     1 ? 
ATOM   1306 C  CA    . GLY A 1 166 ? 0.302   1.634   0.886   1.000 18.323  0 166 GLY A CA    1 ? 
ATOM   1307 C  C     . GLY A 1 166 ? 1.392   0.644   1.309   1.000 18.116  0 166 GLY A C     1 ? 
ATOM   1308 O  O     . GLY A 1 166 ? 1.086   -0.536  1.549   1.000 16.580  0 166 GLY A O     1 ? 
ATOM   1309 N  N     . PHE A 1 167 ? 2.624   1.135   1.439   1.000 18.840  0 167 PHE A N     1 ? 
ATOM   1310 C  CA    . PHE A 1 167 ? 3.788   0.326   1.853   1.000 18.205  0 167 PHE A CA    1 ? 
ATOM   1311 C  C     . PHE A 1 167 ? 3.566   -0.170  3.286   1.000 17.012  0 167 PHE A C     1 ? 
ATOM   1312 O  O     . PHE A 1 167 ? 3.786   -1.341  3.546   1.000 15.466  0 167 PHE A O     1 ? 
ATOM   1313 C  CB    . PHE A 1 167 ? 5.086   1.118   1.733   1.000 19.001  0 167 PHE A CB    1 ? 
ATOM   1314 C  CG    . PHE A 1 167 ? 6.313   0.265   1.934   1.000 19.438  0 167 PHE A CG    1 ? 
ATOM   1315 C  CD1   . PHE A 1 167 ? 6.529   -0.853  1.150   1.000 19.307  0 167 PHE A CD1   1 ? 
ATOM   1316 C  CD2   . PHE A 1 167 ? 7.222   0.544   2.933   1.000 21.739  0 167 PHE A CD2   1 ? 
ATOM   1317 C  CE1   . PHE A 1 167 ? 7.639   -1.667  1.347   1.000 18.960  0 167 PHE A CE1   1 ? 
ATOM   1318 C  CE2   . PHE A 1 167 ? 8.337   -0.266  3.122   1.000 20.414  0 167 PHE A CE2   1 ? 
ATOM   1319 C  CZ    . PHE A 1 167 ? 8.538   -1.368  2.333   1.000 20.254  0 167 PHE A CZ    1 ? 
ATOM   1320 N  N     . GLN A 1 168 ? 3.153   0.721   4.178   1.000 16.100  0 168 GLN A N     1 ? 
ATOM   1321 C  CA    . GLN A 1 168 ? 2.932   0.405   5.602   1.000 17.808  0 168 GLN A CA    1 ? 
ATOM   1322 C  C     . GLN A 1 168 ? 1.861   -0.679  5.691   1.000 18.212  0 168 GLN A C     1 ? 
ATOM   1323 O  O     . GLN A 1 168 ? 2.084   -1.627  6.415   1.000 16.372  0 168 GLN A O     1 ? 
ATOM   1324 C  CB    . GLN A 1 168 ? 2.516   1.671   6.333   1.000 19.007  0 168 GLN A CB    1 ? 
ATOM   1325 C  CG    . GLN A 1 168 ? 3.620   2.719   6.356   1.000 23.492  0 168 GLN A CG    1 ? 
ATOM   1326 C  CD    . GLN A 1 168 ? 3.178   3.986   7.057   1.000 26.369  0 168 GLN A CD    1 ? 
ATOM   1327 O  OE1   . GLN A 1 168 ? 3.472   5.098   6.616   1.000 32.851  0 168 GLN A OE1   1 ? 
ATOM   1328 N  NE2   . GLN A 1 168 ? 2.467   3.815   8.171   1.000 24.621  0 168 GLN A NE2   1 ? 
ATOM   1329 N  N     . ASP A 1 169 ? 0.757   -0.527  4.943   1.000 20.153  0 169 ASP A N     1 ? 
ATOM   1330 C  CA    . ASP A 1 169 ? -0.319  -1.543  4.826   1.000 20.852  0 169 ASP A CA    1 ? 
ATOM   1331 C  C     . ASP A 1 169 ? 0.245   -2.891  4.332   1.000 20.299  0 169 ASP A C     1 ? 
ATOM   1332 O  O     . ASP A 1 169 ? -0.089  -3.951  4.921   1.000 17.202  0 169 ASP A O     1 ? 
ATOM   1333 C  CB    . ASP A 1 169 ? -1.436  -1.067  3.897   1.000 23.250  0 169 ASP A CB    1 ? 
ATOM   1334 C  CG    . ASP A 1 169 ? -2.593  -2.049  3.854   1.000 24.190  0 169 ASP A CG    1 ? 
ATOM   1335 O  OD1   . ASP A 1 169 ? -3.199  -2.202  2.762   1.000 31.219  0 169 ASP A OD1   1 ? 
ATOM   1336 O  OD2   . ASP A 1 169 ? -2.867  -2.662  4.894   1.000 19.211  0 169 ASP A OD2   1 ? 
ATOM   1337 N  N     . ARG A 1 170 ? 1.081   -2.867  3.296   1.000 18.954  0 170 ARG A N     1 ? 
ATOM   1338 C  CA    . ARG A 1 170 ? 1.682   -4.081  2.698   1.000 18.575  0 170 ARG A CA    1 ? 
ATOM   1339 C  C     . ARG A 1 170 ? 2.543   -4.810  3.740   1.000 17.217  0 170 ARG A C     1 ? 
ATOM   1340 O  O     . ARG A 1 170 ? 2.385   -6.047  3.865   1.000 14.877  0 170 ARG A O     1 ? 
ATOM   1341 C  CB    . ARG A 1 170 ? 2.515   -3.686  1.485   1.000 20.898  0 170 ARG A CB    1 ? 
ATOM   1342 C  CG    . ARG A 1 170 ? 1.664   -3.212  0.317   1.000 24.549  0 170 ARG A CG    1 ? 
ATOM   1343 C  CD    . ARG A 1 170 ? 1.327   -4.377  -0.580  1.000 24.950  0 170 ARG A CD    1 ? 
ATOM   1344 N  NE    . ARG A 1 170 ? 0.186   -4.159  -1.450  1.000 26.605  0 170 ARG A NE    1 ? 
ATOM   1345 C  CZ    . ARG A 1 170 ? -0.216  -5.048  -2.355  1.000 26.363  0 170 ARG A CZ    1 ? 
ATOM   1346 N  NH1   . ARG A 1 170 ? 0.461   -6.181  -2.513  1.000 25.924  0 170 ARG A NH1   1 ? 
ATOM   1347 N  NH2   . ARG A 1 170 ? -1.298  -4.817  -3.075  1.000 25.378  0 170 ARG A NH2   1 ? 
ATOM   1348 N  N     . ILE A 1 171 ? 3.344   -4.079  4.532   1.000 16.341  0 171 ILE A N     1 ? 
ATOM   1349 C  CA    . ILE A 1 171 ? 4.225   -4.701  5.580   1.000 16.472  0 171 ILE A CA    1 ? 
ATOM   1350 C  C     . ILE A 1 171 ? 3.370   -5.236  6.753   1.000 18.018  0 171 ILE A C     1 ? 
ATOM   1351 O  O     . ILE A 1 171 ? 3.693   -6.332  7.254   1.000 17.819  0 171 ILE A O     1 ? 
ATOM   1352 C  CB    . ILE A 1 171 ? 5.350   -3.717  6.009   1.000 16.503  0 171 ILE A CB    1 ? 
ATOM   1353 C  CG1   . ILE A 1 171 ? 6.240   -3.353  4.810   1.000 15.786  0 171 ILE A CG1   1 ? 
ATOM   1354 C  CG2   . ILE A 1 171 ? 6.191   -4.241  7.158   1.000 15.217  0 171 ILE A CG2   1 ? 
ATOM   1355 C  CD1   . ILE A 1 171 ? 6.768   -4.552  4.051   1.000 15.817  0 171 ILE A CD1   1 ? 
ATOM   1356 N  N     . ALA A 1 172 ? 2.277   -4.549  7.127   1.000 18.761  0 172 ALA A N     1 ? 
ATOM   1357 C  CA    . ALA A 1 172 ? 1.392   -4.900  8.269   1.000 18.510  0 172 ALA A CA    1 ? 
ATOM   1358 C  C     . ALA A 1 172 ? 0.552   -6.134  7.884   1.000 19.037  0 172 ALA A C     1 ? 
ATOM   1359 O  O     . ALA A 1 172 ? 0.271   -6.976  8.782   1.000 17.331  0 172 ALA A O     1 ? 
ATOM   1360 C  CB    . ALA A 1 172 ? 0.545   -3.696  8.664   1.000 16.975  0 172 ALA A CB    1 ? 
ATOM   1361 N  N     . SER A 1 173 ? 0.241   -6.284  6.589   1.000 19.955  0 173 SER A N     1 ? 
ATOM   1362 C  CA    . SER A 1 173 ? -0.847  -7.172  6.088   1.000 20.087  0 173 SER A CA    1 ? 
ATOM   1363 C  C     . SER A 1 173 ? -0.306  -8.483  5.554   1.000 19.147  0 173 SER A C     1 ? 
ATOM   1364 O  O     . SER A 1 173 ? -1.105  -9.400  5.493   1.000 19.178  0 173 SER A O     1 ? 
ATOM   1365 C  CB    . SER A 1 173 ? -1.694  -6.504  5.036   1.000 21.436  0 173 SER A CB    1 ? 
ATOM   1366 O  OG    . SER A 1 173 ? -2.266  -5.335  5.552   1.000 21.023  0 173 SER A OG    1 ? 
ATOM   1367 N  N     . LYS A 1 174 ? 0.999   -8.588  5.272   1.000 18.258  0 174 LYS A N     1 ? 
ATOM   1368 C  CA    . LYS A 1 174 ? 1.578   -9.776  4.590   1.000 16.965  0 174 LYS A CA    1 ? 
ATOM   1369 C  C     . LYS A 1 174 ? 1.303   -11.040 5.427   1.000 15.991  0 174 LYS A C     1 ? 
ATOM   1370 O  O     . LYS A 1 174 ? 0.901   -12.083 4.865   1.000 14.977  0 174 LYS A O     1 ? 
ATOM   1371 C  CB    . LYS A 1 174 ? 3.068   -9.574  4.342   1.000 18.158  0 174 LYS A CB    1 ? 
ATOM   1372 C  CG    . LYS A 1 174 ? 3.784   -10.780 3.744   1.000 20.071  0 174 LYS A CG    1 ? 
ATOM   1373 C  CD    . LYS A 1 174 ? 5.312   -10.680 3.747   1.000 20.302  0 174 LYS A CD    1 ? 
ATOM   1374 C  CE    . LYS A 1 174 ? 6.011   -11.948 3.310   1.000 19.844  0 174 LYS A CE    1 ? 
ATOM   1375 N  NZ    . LYS A 1 174 ? 5.749   -12.299 1.885   1.000 21.907  0 174 LYS A NZ    1 ? 
ATOM   1376 N  N     . LEU A 1 175 ? 1.439   -10.949 6.735   1.000 14.798  0 175 LEU A N     1 ? 
ATOM   1377 C  CA    . LEU A 1 175 ? 1.172   -12.076 7.658   1.000 15.571  0 175 LEU A CA    1 ? 
ATOM   1378 C  C     . LEU A 1 175 ? 0.313   -11.578 8.814   1.000 15.341  0 175 LEU A C     1 ? 
ATOM   1379 O  O     . LEU A 1 175 ? 0.033   -10.377 8.867   1.000 14.874  0 175 LEU A O     1 ? 
ATOM   1380 C  CB    . LEU A 1 175 ? 2.536   -12.597 8.136   1.000 16.678  0 175 LEU A CB    1 ? 
ATOM   1381 C  CG    . LEU A 1 175 ? 3.383   -13.313 7.065   1.000 17.771  0 175 LEU A CG    1 ? 
ATOM   1382 C  CD1   . LEU A 1 175 ? 4.814   -13.444 7.524   1.000 18.383  0 175 LEU A CD1   1 ? 
ATOM   1383 C  CD2   . LEU A 1 175 ? 2.792   -14.677 6.749   1.000 17.147  0 175 LEU A CD2   1 ? 
ATOM   1384 N  N     . SER A 1 176 ? 0.003   -12.461 9.759   1.000 17.703  0 176 SER A N     1 ? 
ATOM   1385 C  CA    . SER A 1 176 ? -0.755  -12.130 10.989  1.000 17.659  0 176 SER A CA    1 ? 
ATOM   1386 C  C     . SER A 1 176 ? -0.138  -12.787 12.227  1.000 17.111  0 176 SER A C     1 ? 
ATOM   1387 O  O     . SER A 1 176 ? 0.581   -13.768 12.111  1.000 16.736  0 176 SER A O     1 ? 
ATOM   1388 C  CB    . SER A 1 176 ? -2.180  -12.553 10.832  1.000 20.289  0 176 SER A CB    1 ? 
ATOM   1389 O  OG    . SER A 1 176 ? -2.277  -13.945 11.007  1.000 20.851  0 176 SER A OG    1 ? 
ATOM   1390 N  N     . GLY A 1 177 ? -0.418  -12.223 13.396  1.000 18.533  0 177 GLY A N     1 ? 
ATOM   1391 C  CA    . GLY A 1 177 ? -0.134  -12.849 14.696  1.000 17.912  0 177 GLY A CA    1 ? 
ATOM   1392 C  C     . GLY A 1 177 ? 1.322   -13.208 14.822  1.000 17.655  0 177 GLY A C     1 ? 
ATOM   1393 O  O     . GLY A 1 177 ? 2.135   -12.390 14.432  1.000 19.168  0 177 GLY A O     1 ? 
ATOM   1394 N  N     . ASP A 1 178 ? 1.615   -14.414 15.284  1.000 18.308  0 178 ASP A N     1 ? 
ATOM   1395 C  CA    . ASP A 1 178 ? 3.004   -14.850 15.596  1.000 18.502  0 178 ASP A CA    1 ? 
ATOM   1396 C  C     . ASP A 1 178 ? 3.796   -15.011 14.290  1.000 15.691  0 178 ASP A C     1 ? 
ATOM   1397 O  O     . ASP A 1 178 ? 5.014   -14.842 14.302  1.000 14.216  0 178 ASP A O     1 ? 
ATOM   1398 C  CB    . ASP A 1 178 ? 2.997   -16.094 16.482  1.000 18.879  0 178 ASP A CB    1 ? 
ATOM   1399 C  CG    . ASP A 1 178 ? 2.450   -15.855 17.883  1.000 21.304  0 178 ASP A CG    1 ? 
ATOM   1400 O  OD1   . ASP A 1 178 ? 2.511   -14.695 18.388  1.000 24.842  0 178 ASP A OD1   1 ? 
ATOM   1401 O  OD2   . ASP A 1 178 ? 1.986   -16.821 18.467  1.000 22.736  0 178 ASP A OD2   1 ? 
ATOM   1402 N  N     . ASP A 1 179 ? 3.138   -15.263 13.178  1.000 17.250  0 179 ASP A N     1 ? 
ATOM   1403 C  CA    . ASP A 1 179 ? 3.856   -15.320 11.882  1.000 16.178  0 179 ASP A CA    1 ? 
ATOM   1404 C  C     . ASP A 1 179 ? 4.427   -13.930 11.588  1.000 16.370  0 179 ASP A C     1 ? 
ATOM   1405 O  O     . ASP A 1 179 ? 5.674   -13.808 11.322  1.000 12.469  0 179 ASP A O     1 ? 
ATOM   1406 C  CB    . ASP A 1 179 ? 2.945   -15.784 10.766  1.000 17.562  0 179 ASP A CB    1 ? 
ATOM   1407 C  CG    . ASP A 1 179 ? 2.573   -17.253 10.780  1.000 18.629  0 179 ASP A CG    1 ? 
ATOM   1408 O  OD1   . ASP A 1 179 ? 3.135   -18.023 11.618  1.000 19.542  0 179 ASP A OD1   1 ? 
ATOM   1409 O  OD2   . ASP A 1 179 ? 1.738   -17.620 9.905   1.000 20.707  0 179 ASP A OD2   1 ? 
ATOM   1410 N  N     . ALA A 1 180 ? 3.595   -12.903 11.698  1.000 14.157  0 180 ALA A N     1 ? 
ATOM   1411 C  CA    . ALA A 1 180 ? 3.980   -11.497 11.450  1.000 15.177  0 180 ALA A CA    1 ? 
ATOM   1412 C  C     . ALA A 1 180 ? 4.998   -11.029 12.495  1.000 16.367  0 180 ALA A C     1 ? 
ATOM   1413 O  O     . ALA A 1 180 ? 5.889   -10.229 12.131  1.000 13.785  0 180 ALA A O     1 ? 
ATOM   1414 C  CB    . ALA A 1 180 ? 2.771   -10.596 11.471  1.000 16.423  0 180 ALA A CB    1 ? 
ATOM   1415 N  N     . ALA A 1 181 ? 4.875   -11.468 13.752  1.000 14.648  0 181 ALA A N     1 ? 
ATOM   1416 C  CA    . ALA A 1 181 ? 5.919   -11.208 14.760  1.000 15.081  0 181 ALA A CA    1 ? 
ATOM   1417 C  C     . ALA A 1 181 ? 7.279   -11.742 14.266  1.000 14.701  0 181 ALA A C     1 ? 
ATOM   1418 O  O     . ALA A 1 181 ? 8.276   -11.005 14.382  1.000 14.064  0 181 ALA A O     1 ? 
ATOM   1419 C  CB    . ALA A 1 181 ? 5.552   -11.815 16.097  1.000 16.006  0 181 ALA A CB    1 ? 
ATOM   1420 N  N     . GLN A 1 182 ? 7.354   -12.983 13.779  1.000 14.718  0 182 GLN A N     1 ? 
ATOM   1421 C  CA    . GLN A 1 182 ? 8.651   -13.582 13.347  1.000 14.833  0 182 GLN A CA    1 ? 
ATOM   1422 C  C     . GLN A 1 182 ? 9.197   -12.740 12.186  1.000 14.542  0 182 GLN A C     1 ? 
ATOM   1423 O  O     . GLN A 1 182 ? 10.373  -12.434 12.192  1.000 14.964  0 182 GLN A O     1 ? 
ATOM   1424 C  CB    . GLN A 1 182 ? 8.512   -15.029 12.895  1.000 14.768  0 182 GLN A CB    1 ? 
ATOM   1425 C  CG    . GLN A 1 182 ? 9.866   -15.663 12.615  1.000 13.730  0 182 GLN A CG    1 ? 
ATOM   1426 C  CD    . GLN A 1 182 ? 9.753   -17.097 12.194  1.000 13.064  0 182 GLN A CD    1 ? 
ATOM   1427 O  OE1   . GLN A 1 182 ? 9.105   -17.428 11.208  1.000 14.608  0 182 GLN A OE1   1 ? 
ATOM   1428 N  NE2   . GLN A 1 182 ? 10.473  -17.965 12.880  1.000 14.429  0 182 GLN A NE2   1 ? 
ATOM   1429 N  N     . PHE A 1 183 ? 8.345   -12.371 11.232  1.000 15.093  0 183 PHE A N     1 ? 
ATOM   1430 C  CA    . PHE A 1 183 ? 8.695   -11.472 10.088  1.000 13.483  0 183 PHE A CA    1 ? 
ATOM   1431 C  C     . PHE A 1 183 ? 9.351   -10.192 10.624  1.000 13.798  0 183 PHE A C     1 ? 
ATOM   1432 O  O     . PHE A 1 183 ? 10.497  -9.853  10.175  1.000 14.410  0 183 PHE A O     1 ? 
ATOM   1433 C  CB    . PHE A 1 183 ? 7.425   -11.218 9.271   1.000 13.529  0 183 PHE A CB    1 ? 
ATOM   1434 C  CG    . PHE A 1 183 ? 7.425   -10.144 8.209   1.000 13.383  0 183 PHE A CG    1 ? 
ATOM   1435 C  CD1   . PHE A 1 183 ? 8.164   -10.277 7.048   1.000 13.286  0 183 PHE A CD1   1 ? 
ATOM   1436 C  CD2   . PHE A 1 183 ? 6.553   -9.064  8.298   1.000 13.830  0 183 PHE A CD2   1 ? 
ATOM   1437 C  CE1   . PHE A 1 183 ? 8.105   -9.311  6.057   1.000 13.637  0 183 PHE A CE1   1 ? 
ATOM   1438 C  CE2   . PHE A 1 183 ? 6.453   -8.130  7.277   1.000 13.254  0 183 PHE A CE2   1 ? 
ATOM   1439 C  CZ    . PHE A 1 183 ? 7.241   -8.256  6.157   1.000 13.924  0 183 PHE A CZ    1 ? 
ATOM   1440 N  N     . ARG A 1 184 ? 8.680   -9.481  11.541  1.000 12.717  0 184 ARG A N     1 ? 
ATOM   1441 C  CA    . ARG A 1 184 ? 9.205   -8.240  12.161  1.000 13.697  0 184 ARG A CA    1 ? 
ATOM   1442 C  C     . ARG A 1 184 ? 10.514  -8.550  12.907  1.000 13.709  0 184 ARG A C     1 ? 
ATOM   1443 O  O     . ARG A 1 184 ? 11.482  -7.795  12.725  1.000 12.721  0 184 ARG A O     1 ? 
ATOM   1444 C  CB    . ARG A 1 184 ? 8.146   -7.585  13.058  1.000 14.977  0 184 ARG A CB    1 ? 
ATOM   1445 C  CG    . ARG A 1 184 ? 6.918   -7.112  12.275  1.000 14.754  0 184 ARG A CG    1 ? 
ATOM   1446 C  CD    . ARG A 1 184 ? 5.994   -6.214  13.051  1.000 16.015  0 184 ARG A CD    1 ? 
ATOM   1447 N  NE    . ARG A 1 184 ? 5.658   -6.845  14.326  1.000 16.895  0 184 ARG A NE    1 ? 
ATOM   1448 C  CZ    . ARG A 1 184 ? 4.570   -7.573  14.541  1.000 18.726  0 184 ARG A CZ    1 ? 
ATOM   1449 N  NH1   . ARG A 1 184 ? 3.689   -7.752  13.583  1.000 21.371  0 184 ARG A NH1   1 ? 
ATOM   1450 N  NH2   . ARG A 1 184 ? 4.342   -8.105  15.723  1.000 19.856  0 184 ARG A NH2   1 ? 
ATOM   1451 N  N     . ARG A 1 185 ? 10.568  -9.599  13.724  1.000 14.457  0 185 ARG A N     1 ? 
ATOM   1452 C  CA    . ARG A 1 185 ? 11.835  -9.968  14.419  1.000 14.696  0 185 ARG A CA    1 ? 
ATOM   1453 C  C     . ARG A 1 185 ? 12.962  -10.094 13.386  1.000 15.166  0 185 ARG A C     1 ? 
ATOM   1454 O  O     . ARG A 1 185 ? 14.103  -9.554  13.626  1.000 17.059  0 185 ARG A O     1 ? 
ATOM   1455 C  CB    . ARG A 1 185 ? 11.709  -11.242 15.259  1.000 14.884  0 185 ARG A CB    1 ? 
ATOM   1456 C  CG    . ARG A 1 185 ? 10.827  -11.127 16.501  1.000 14.082  0 185 ARG A CG    1 ? 
ATOM   1457 C  CD    . ARG A 1 185 ? 11.089  -12.243 17.499  1.000 14.459  0 185 ARG A CD    1 ? 
ATOM   1458 N  NE    . ARG A 1 185 ? 10.867  -13.589 16.949  1.000 14.302  0 185 ARG A NE    1 ? 
ATOM   1459 C  CZ    . ARG A 1 185 ? 9.673   -14.182 16.859  1.000 14.565  0 185 ARG A CZ    1 ? 
ATOM   1460 N  NH1   . ARG A 1 185 ? 8.584   -13.582 17.325  1.000 14.538  0 185 ARG A NH1   1 ? 
ATOM   1461 N  NH2   . ARG A 1 185 ? 9.565   -15.362 16.290  1.000 14.202  0 185 ARG A NH2   1 ? 
ATOM   1462 N  N     . CYS A 1 186 ? 12.713  -10.763 12.267  1.000 14.843  0 186 CYS A N     1 ? 
ATOM   1463 C  CA    . CYS A 1 186 ? 13.792  -11.049 11.283  1.000 13.367  0 186 CYS A CA    1 ? 
ATOM   1464 C  C     . CYS A 1 186 ? 14.255  -9.781  10.559  1.000 13.506  0 186 CYS A C     1 ? 
ATOM   1465 O  O     . CYS A 1 186 ? 15.481  -9.700  10.206  1.000 11.253  0 186 CYS A O     1 ? 
ATOM   1466 C  CB    . CYS A 1 186 ? 13.391  -12.148 10.314  1.000 14.446  0 186 CYS A CB    1 ? 
ATOM   1467 S  SG    . CYS A 1 186 ? 13.372  -13.777 11.093  1.000 17.653  0 186 CYS A SG    1 ? 
ATOM   1468 N  N     . ILE A 1 187 ? 13.346  -8.836  10.299  1.000 12.886  0 187 ILE A N     1 ? 
ATOM   1469 C  CA    . ILE A 1 187 ? 13.690  -7.510  9.732   1.000 12.572  0 187 ILE A CA    1 ? 
ATOM   1470 C  C     . ILE A 1 187 ? 14.618  -6.767  10.719  1.000 12.805  0 187 ILE A C     1 ? 
ATOM   1471 O  O     . ILE A 1 187 ? 15.660  -6.156  10.282  1.000 9.967   0 187 ILE A O     1 ? 
ATOM   1472 C  CB    . ILE A 1 187 ? 12.417  -6.708  9.392   1.000 11.772  0 187 ILE A CB    1 ? 
ATOM   1473 C  CG1   . ILE A 1 187 ? 11.656  -7.329  8.212   1.000 11.975  0 187 ILE A CG1   1 ? 
ATOM   1474 C  CG2   . ILE A 1 187 ? 12.755  -5.231  9.182   1.000 11.953  0 187 ILE A CG2   1 ? 
ATOM   1475 C  CD1   . ILE A 1 187 ? 10.277  -6.699  7.931   1.000 11.089  0 187 ILE A CD1   1 ? 
ATOM   1476 N  N     . ARG A 1 188 ? 14.302  -6.845  12.010  1.000 13.298  0 188 ARG A N     1 ? 
ATOM   1477 C  CA    . ARG A 1 188 ? 15.106  -6.192  13.071  1.000 13.193  0 188 ARG A CA    1 ? 
ATOM   1478 C  C     . ARG A 1 188 ? 16.486  -6.862  13.127  1.000 12.761  0 188 ARG A C     1 ? 
ATOM   1479 O  O     . ARG A 1 188 ? 17.486  -6.154  13.148  1.000 14.588  0 188 ARG A O     1 ? 
ATOM   1480 C  CB    . ARG A 1 188 ? 14.374  -6.259  14.413  1.000 13.901  0 188 ARG A CB    1 ? 
ATOM   1481 C  CG    . ARG A 1 188 ? 13.225  -5.275  14.587  1.000 13.377  0 188 ARG A CG    1 ? 
ATOM   1482 C  CD    . ARG A 1 188 ? 12.678  -5.324  16.000  1.000 13.753  0 188 ARG A CD    1 ? 
ATOM   1483 N  NE    . ARG A 1 188 ? 11.682  -4.270  16.231  1.000 16.651  0 188 ARG A NE    1 ? 
ATOM   1484 C  CZ    . ARG A 1 188 ? 10.374  -4.457  16.460  1.000 15.610  0 188 ARG A CZ    1 ? 
ATOM   1485 N  NH1   . ARG A 1 188 ? 9.847   -5.669  16.544  1.000 16.106  0 188 ARG A NH1   1 ? 
ATOM   1486 N  NH2   . ARG A 1 188 ? 9.596   -3.409  16.622  1.000 15.668  0 188 ARG A NH2   1 ? 
ATOM   1487 N  N     . TYR A 1 189 ? 16.559  -8.183  13.085  1.000 13.888  0 189 TYR A N     1 ? 
ATOM   1488 C  CA    . TYR A 1 189 ? 17.857  -8.897  13.143  1.000 14.185  0 189 TYR A CA    1 ? 
ATOM   1489 C  C     . TYR A 1 189 ? 18.774  -8.341  12.057  1.000 14.801  0 189 TYR A C     1 ? 
ATOM   1490 O  O     . TYR A 1 189 ? 19.930  -8.062  12.320  1.000 13.530  0 189 TYR A O     1 ? 
ATOM   1491 C  CB    . TYR A 1 189 ? 17.703  -10.394 12.965  1.000 14.899  0 189 TYR A CB    1 ? 
ATOM   1492 C  CG    . TYR A 1 189 ? 16.910  -11.111 14.026  1.000 15.244  0 189 TYR A CG    1 ? 
ATOM   1493 C  CD1   . TYR A 1 189 ? 16.949  -10.731 15.369  1.000 15.523  0 189 TYR A CD1   1 ? 
ATOM   1494 C  CD2   . TYR A 1 189 ? 16.063  -12.145 13.677  1.000 14.647  0 189 TYR A CD2   1 ? 
ATOM   1495 C  CE1   . TYR A 1 189 ? 16.182  -11.378 16.324  1.000 14.470  0 189 TYR A CE1   1 ? 
ATOM   1496 C  CE2   . TYR A 1 189 ? 15.275  -12.794 14.631  1.000 14.352  0 189 TYR A CE2   1 ? 
ATOM   1497 C  CZ    . TYR A 1 189 ? 15.348  -12.420 15.957  1.000 13.882  0 189 TYR A CZ    1 ? 
ATOM   1498 O  OH    . TYR A 1 189 ? 14.581  -13.056 16.895  1.000 14.003  0 189 TYR A OH    1 ? 
ATOM   1499 N  N     . LEU A 1 190 ? 18.257  -8.218  10.841  1.000 15.718  0 190 LEU A N     1 ? 
ATOM   1500 C  CA    . LEU A 1 190 ? 19.094  -7.778  9.706   1.000 16.920  0 190 LEU A CA    1 ? 
ATOM   1501 C  C     . LEU A 1 190 ? 19.429  -6.282  9.843   1.000 16.224  0 190 LEU A C     1 ? 
ATOM   1502 O  O     . LEU A 1 190 ? 20.491  -5.920  9.384   1.000 16.345  0 190 LEU A O     1 ? 
ATOM   1503 C  CB    . LEU A 1 190 ? 18.409  -8.139  8.381   1.000 18.516  0 190 LEU A CB    1 ? 
ATOM   1504 C  CG    . LEU A 1 190 ? 18.307  -9.635  8.068   1.000 19.606  0 190 LEU A CG    1 ? 
ATOM   1505 C  CD1   . LEU A 1 190 ? 17.739  -9.865  6.675   1.000 21.593  0 190 LEU A CD1   1 ? 
ATOM   1506 C  CD2   . LEU A 1 190 ? 19.656  -10.332 8.201   1.000 21.131  0 190 LEU A CD2   1 ? 
ATOM   1507 N  N     . LYS A 1 191 ? 18.608  -5.449  10.510  1.000 17.593  0 191 LYS A N     1 ? 
ATOM   1508 C  CA    . LYS A 1 191 ? 18.925  -4.007  10.712  1.000 16.478  0 191 LYS A CA    1 ? 
ATOM   1509 C  C     . LYS A 1 191 ? 20.094  -3.863  11.674  1.000 14.762  0 191 LYS A C     1 ? 
ATOM   1510 O  O     . LYS A 1 191 ? 20.980  -3.032  11.400  1.000 14.660  0 191 LYS A O     1 ? 
ATOM   1511 C  CB    . LYS A 1 191 ? 17.739  -3.202  11.226  1.000 16.757  0 191 LYS A CB    1 ? 
ATOM   1512 C  CG    . LYS A 1 191 ? 16.779  -2.807  10.112  1.000 17.150  0 191 LYS A CG    1 ? 
ATOM   1513 C  CD    . LYS A 1 191 ? 15.481  -2.267  10.558  1.000 16.349  0 191 LYS A CD    1 ? 
ATOM   1514 C  CE    . LYS A 1 191 ? 14.668  -1.747  9.396   1.000 16.989  0 191 LYS A CE    1 ? 
ATOM   1515 N  NZ    . LYS A 1 191 ? 13.457  -1.049  9.866   1.000 17.924  0 191 LYS A NZ    1 ? 
ATOM   1516 N  N     . ARG A 1 192 ? 20.135  -4.666  12.723  1.000 13.531  0 192 ARG A N     1 ? 
ATOM   1517 C  CA    . ARG A 1 192 ? 21.281  -4.643  13.664  1.000 13.308  0 192 ARG A CA    1 ? 
ATOM   1518 C  C     . ARG A 1 192 ? 22.516  -5.186  12.935  1.000 12.878  0 192 ARG A C     1 ? 
ATOM   1519 O  O     . ARG A 1 192 ? 23.592  -4.634  13.128  1.000 12.412  0 192 ARG A O     1 ? 
ATOM   1520 C  CB    . ARG A 1 192 ? 20.950  -5.437  14.937  1.000 14.239  0 192 ARG A CB    1 ? 
ATOM   1521 C  CG    . ARG A 1 192 ? 22.132  -5.670  15.871  1.000 14.111  0 192 ARG A CG    1 ? 
ATOM   1522 C  CD    . ARG A 1 192 ? 22.869  -4.375  16.207  1.000 15.666  0 192 ARG A CD    1 ? 
ATOM   1523 N  NE    . ARG A 1 192 ? 21.969  -3.416  16.851  1.000 15.096  0 192 ARG A NE    1 ? 
ATOM   1524 C  CZ    . ARG A 1 192 ? 21.669  -3.434  18.159  1.000 16.517  0 192 ARG A CZ    1 ? 
ATOM   1525 N  NH1   . ARG A 1 192 ? 22.257  -4.303  18.982  1.000 16.317  0 192 ARG A NH1   1 ? 
ATOM   1526 N  NH2   . ARG A 1 192 ? 20.819  -2.538  18.647  1.000 16.914  0 192 ARG A NH2   1 ? 
ATOM   1527 N  N     . TRP A 1 193 ? 22.346  -6.221  12.116  1.000 13.453  0 193 TRP A N     1 ? 
ATOM   1528 C  CA    . TRP A 1 193 ? 23.444  -6.767  11.278  1.000 13.865  0 193 TRP A CA    1 ? 
ATOM   1529 C  C     . TRP A 1 193 ? 23.957  -5.639  10.394  1.000 13.499  0 193 TRP A C     1 ? 
ATOM   1530 O  O     . TRP A 1 193 ? 25.177  -5.477  10.311  1.000 15.088  0 193 TRP A O     1 ? 
ATOM   1531 C  CB    . TRP A 1 193 ? 22.998  -7.992  10.470  1.000 13.600  0 193 TRP A CB    1 ? 
ATOM   1532 C  CG    . TRP A 1 193 ? 23.947  -8.415  9.394   1.000 13.751  0 193 TRP A CG    1 ? 
ATOM   1533 C  CD1   . TRP A 1 193 ? 25.118  -9.095  9.543   1.000 14.302  0 193 TRP A CD1   1 ? 
ATOM   1534 C  CD2   . TRP A 1 193 ? 23.803  -8.163  7.981   1.000 13.089  0 193 TRP A CD2   1 ? 
ATOM   1535 N  NE1   . TRP A 1 193 ? 25.707  -9.282  8.317   1.000 13.744  0 193 TRP A NE1   1 ? 
ATOM   1536 C  CE2   . TRP A 1 193 ? 24.910  -8.752  7.339   1.000 13.302  0 193 TRP A CE2   1 ? 
ATOM   1537 C  CE3   . TRP A 1 193 ? 22.816  -7.550  7.193   1.000 14.190  0 193 TRP A CE3   1 ? 
ATOM   1538 C  CZ2   . TRP A 1 193 ? 25.076  -8.733  5.956   1.000 12.510  0 193 TRP A CZ2   1 ? 
ATOM   1539 C  CZ3   . TRP A 1 193 ? 22.970  -7.539  5.814   1.000 14.357  0 193 TRP A CZ3   1 ? 
ATOM   1540 C  CH2   . TRP A 1 193 ? 24.102  -8.115  5.211   1.000 13.429  0 193 TRP A CH2   1 ? 
ATOM   1541 N  N     . ARG A 1 194 ? 23.066  -4.851  9.808   1.000 15.049  0 194 ARG A N     1 ? 
ATOM   1542 C  CA    . ARG A 1 194 ? 23.453  -3.716  8.929   1.000 16.502  0 194 ARG A CA    1 ? 
ATOM   1543 C  C     . ARG A 1 194 ? 24.304  -2.731  9.759   1.000 15.315  0 194 ARG A C     1 ? 
ATOM   1544 O  O     . ARG A 1 194 ? 25.375  -2.328  9.313   1.000 14.790  0 194 ARG A O     1 ? 
ATOM   1545 C  CB    . ARG A 1 194 ? 22.214  -3.024  8.331   1.000 18.332  0 194 ARG A CB    1 ? 
ATOM   1546 C  CG    . ARG A 1 194 ? 22.486  -1.601  7.836   1.000 22.538  0 194 ARG A CG    1 ? 
ATOM   1547 C  CD    . ARG A 1 194 ? 21.361  -0.568  7.949   1.000 26.001  0 194 ARG A CD    1 ? 
ATOM   1548 N  NE    . ARG A 1 194 ? 20.860  -0.359  9.306   1.000 27.594  0 194 ARG A NE    1 ? 
ATOM   1549 C  CZ    . ARG A 1 194 ? 19.623  0.064   9.630   1.000 30.917  0 194 ARG A CZ    1 ? 
ATOM   1550 N  NH1   . ARG A 1 194 ? 18.712  0.312   8.701   1.000 32.283  0 194 ARG A NH1   1 ? 
ATOM   1551 N  NH2   . ARG A 1 194 ? 19.285  0.217   10.898  1.000 30.504  0 194 ARG A NH2   1 ? 
ATOM   1552 N  N     . ASP A 1 195 ? 23.815  -2.360  10.929  1.000 15.300  0 195 ASP A N     1 ? 
ATOM   1553 C  CA    . ASP A 1 195 ? 24.462  -1.380  11.836  1.000 16.853  0 195 ASP A CA    1 ? 
ATOM   1554 C  C     . ASP A 1 195 ? 25.827  -1.885  12.319  1.000 16.579  0 195 ASP A C     1 ? 
ATOM   1555 O  O     . ASP A 1 195 ? 26.747  -1.076  12.352  1.000 18.647  0 195 ASP A O     1 ? 
ATOM   1556 C  CB    . ASP A 1 195 ? 23.551  -1.074  13.010  1.000 16.295  0 195 ASP A CB    1 ? 
ATOM   1557 C  CG    . ASP A 1 195 ? 22.331  -0.282  12.598  1.000 20.241  0 195 ASP A CG    1 ? 
ATOM   1558 O  OD1   . ASP A 1 195 ? 22.284  0.203   11.439  1.000 20.535  0 195 ASP A OD1   1 ? 
ATOM   1559 O  OD2   . ASP A 1 195 ? 21.449  -0.132  13.438  1.000 23.118  0 195 ASP A OD2   1 ? 
ATOM   1560 N  N     . PHE A 1 196 ? 25.943  -3.167  12.656  1.000 16.614  0 196 PHE A N     1 ? 
ATOM   1561 C  CA    . PHE A 1 196 ? 27.193  -3.790  13.165  1.000 16.720  0 196 PHE A CA    1 ? 
ATOM   1562 C  C     . PHE A 1 196 ? 28.250  -3.893  12.062  1.000 17.455  0 196 PHE A C     1 ? 
ATOM   1563 O  O     . PHE A 1 196 ? 29.422  -3.601  12.377  1.000 17.378  0 196 PHE A O     1 ? 
ATOM   1564 C  CB    . PHE A 1 196 ? 26.984  -5.181  13.736  1.000 16.376  0 196 PHE A CB    1 ? 
ATOM   1565 C  CG    . PHE A 1 196 ? 28.204  -5.768  14.400  1.000 15.906  0 196 PHE A CG    1 ? 
ATOM   1566 C  CD1   . PHE A 1 196 ? 28.918  -5.043  15.343  1.000 16.947  0 196 PHE A CD1   1 ? 
ATOM   1567 C  CD2   . PHE A 1 196 ? 28.662  -7.026  14.062  1.000 16.535  0 196 PHE A CD2   1 ? 
ATOM   1568 C  CE1   . PHE A 1 196 ? 30.050  -5.579  15.947  1.000 17.342  0 196 PHE A CE1   1 ? 
ATOM   1569 C  CE2   . PHE A 1 196 ? 29.794  -7.560  14.664  1.000 16.919  0 196 PHE A CE2   1 ? 
ATOM   1570 C  CZ    . PHE A 1 196 ? 30.488  -6.831  15.608  1.000 17.685  0 196 PHE A CZ    1 ? 
ATOM   1571 N  N     . ARG A 1 197 ? 27.889  -4.344  10.855  1.000 17.458  0 197 ARG A N     1 ? 
ATOM   1572 C  CA    . ARG A 1 197 ? 28.887  -4.749  9.826   1.000 17.344  0 197 ARG A CA    1 ? 
ATOM   1573 C  C     . ARG A 1 197 ? 28.988  -3.715  8.695   1.000 19.819  0 197 ARG A C     1 ? 
ATOM   1574 O  O     . ARG A 1 197 ? 29.858  -3.920  7.801   1.000 17.253  0 197 ARG A O     1 ? 
ATOM   1575 C  CB    . ARG A 1 197 ? 28.547  -6.126  9.258   1.000 17.182  0 197 ARG A CB    1 ? 
ATOM   1576 C  CG    . ARG A 1 197 ? 28.497  -7.226  10.306  1.000 17.653  0 197 ARG A CG    1 ? 
ATOM   1577 C  CD    . ARG A 1 197 ? 29.260  -8.457  9.900   1.000 18.229  0 197 ARG A CD    1 ? 
ATOM   1578 N  NE    . ARG A 1 197 ? 30.702  -8.261  9.810   1.000 17.282  0 197 ARG A NE    1 ? 
ATOM   1579 C  CZ    . ARG A 1 197 ? 31.512  -9.017  9.056   1.000 18.892  0 197 ARG A CZ    1 ? 
ATOM   1580 N  NH1   . ARG A 1 197 ? 31.018  -10.006 8.326   1.000 17.159  0 197 ARG A NH1   1 ? 
ATOM   1581 N  NH2   . ARG A 1 197 ? 32.804  -8.745  8.972   1.000 17.394  0 197 ARG A NH2   1 ? 
ATOM   1582 N  N     . PHE A 1 198 ? 28.181  -2.652  8.702   1.000 18.484  0 198 PHE A N     1 ? 
ATOM   1583 C  CA    . PHE A 1 198 ? 28.228  -1.603  7.637   1.000 22.201  0 198 PHE A CA    1 ? 
ATOM   1584 C  C     . PHE A 1 198 ? 28.375  -0.196  8.241   1.000 25.375  0 198 PHE A C     1 ? 
ATOM   1585 O  O     . PHE A 1 198 ? 28.196  -0.034  9.431   1.000 33.967  0 198 PHE A O     1 ? 
ATOM   1586 C  CB    . PHE A 1 198 ? 26.990  -1.669  6.734   1.000 20.143  0 198 PHE A CB    1 ? 
ATOM   1587 C  CG    . PHE A 1 198 ? 26.814  -2.954  5.960   1.000 18.589  0 198 PHE A CG    1 ? 
ATOM   1588 C  CD1   . PHE A 1 198 ? 26.335  -4.095  6.577   1.000 18.837  0 198 PHE A CD1   1 ? 
ATOM   1589 C  CD2   . PHE A 1 198 ? 27.097  -3.023  4.607   1.000 19.574  0 198 PHE A CD2   1 ? 
ATOM   1590 C  CE1   . PHE A 1 198 ? 26.150  -5.277  5.866   1.000 20.270  0 198 PHE A CE1   1 ? 
ATOM   1591 C  CE2   . PHE A 1 198 ? 26.888  -4.193  3.887   1.000 18.926  0 198 PHE A CE2   1 ? 
ATOM   1592 C  CZ    . PHE A 1 198 ? 26.397  -5.315  4.511   1.000 19.211  0 198 PHE A CZ    1 ? 
ATOM   1593 N  N     . SER A 1 199 ? 28.754  0.772   7.414   1.000 33.189  0 199 SER A N     1 ? 
ATOM   1594 C  CA    . SER A 1 199 ? 29.075  2.178   7.784   1.000 39.493  0 199 SER A CA    1 ? 
ATOM   1595 C  C     . SER A 1 199 ? 27.781  2.979   7.788   1.000 45.550  0 199 SER A C     1 ? 
ATOM   1596 O  O     . SER A 1 199 ? 27.010  2.841   6.824   1.000 50.685  0 199 SER A O     1 ? 
ATOM   1597 C  CB    . SER A 1 199 ? 30.077  2.827   6.838   1.000 40.479  0 199 SER A CB    1 ? 
ATOM   1598 O  OG    . SER A 1 199 ? 31.320  2.137   6.830   1.000 40.938  0 199 SER A OG    1 ? 
ATOM   1599 N  N     . SER A 1 200 ? 27.564  3.787   8.827   1.000 57.595  0 200 SER A N     1 ? 
ATOM   1600 C  CA    . SER A 1 200 ? 26.396  4.700   8.957   1.000 63.358  0 200 SER A CA    1 ? 
ATOM   1601 C  C     . SER A 1 200 ? 26.495  5.799   7.890   1.000 67.840  0 200 SER A C     1 ? 
ATOM   1602 O  O     . SER A 1 200 ? 27.637  6.145   7.489   1.000 65.963  0 200 SER A O     1 ? 
ATOM   1603 C  CB    . SER A 1 200 ? 26.293  5.272   10.352  1.000 65.702  0 200 SER A CB    1 ? 
ATOM   1604 O  OG    . SER A 1 200 ? 27.286  6.265   10.578  1.000 68.538  0 200 SER A OG    1 ? 
ATOM   1605 N  N     . ASP A 1 201 ? 25.346  6.288   7.413   1.000 72.386  0 201 ASP A N     1 ? 
ATOM   1606 C  CA    . ASP A 1 201 ? 25.256  7.332   6.357   1.000 79.746  0 201 ASP A CA    1 ? 
ATOM   1607 C  C     . ASP A 1 201 ? 26.294  7.025   5.267   1.000 81.613  0 201 ASP A C     1 ? 
ATOM   1608 O  O     . ASP A 1 201 ? 26.869  7.975   4.709   1.000 86.321  0 201 ASP A O     1 ? 
ATOM   1609 C  CB    . ASP A 1 201 ? 25.418  8.738   6.957   1.000 81.868  0 201 ASP A CB    1 ? 
ATOM   1610 C  CG    . ASP A 1 201 ? 24.106  9.458   7.243   1.000 84.059  0 201 ASP A CG    1 ? 
ATOM   1611 O  OD1   . ASP A 1 201 ? 23.201  9.402   6.385   1.000 82.602  0 201 ASP A OD1   1 ? 
ATOM   1612 O  OD2   . ASP A 1 201 ? 23.996  10.073  8.325   1.000 82.380  0 201 ASP A OD2   1 ? 
ATOM   1613 N  N     . GLY A 1 202 ? 26.548  5.738   5.013   1.000 82.599  0 202 GLY A N     1 ? 
ATOM   1614 C  CA    . GLY A 1 202 ? 27.211  5.239   3.798   1.000 73.926  0 202 GLY A CA    1 ? 
ATOM   1615 C  C     . GLY A 1 202 ? 26.171  4.569   2.932   1.000 73.583  0 202 GLY A C     1 ? 
ATOM   1616 O  O     . GLY A 1 202 ? 25.342  3.815   3.500   1.000 71.427  0 202 GLY A O     1 ? 
ATOM   1617 N  N     . ASN A 1 203 ? 26.150  4.889   1.634   1.000 70.676  0 203 ASN A N     1 ? 
ATOM   1618 C  CA    . ASN A 1 203 ? 25.296  4.202   0.626   1.000 65.973  0 203 ASN A CA    1 ? 
ATOM   1619 C  C     . ASN A 1 203 ? 25.642  2.708   0.662   1.000 60.176  0 203 ASN A C     1 ? 
ATOM   1620 O  O     . ASN A 1 203 ? 24.755  1.891   0.336   1.000 58.889  0 203 ASN A O     1 ? 
ATOM   1621 C  CB    . ASN A 1 203 ? 25.468  4.793   -0.779  1.000 64.617  0 203 ASN A CB    1 ? 
ATOM   1622 C  CG    . ASN A 1 203 ? 24.179  4.863   -1.567  1.000 67.807  0 203 ASN A CG    1 ? 
ATOM   1623 O  OD1   . ASN A 1 203 ? 23.803  5.936   -2.036  1.000 72.368  0 203 ASN A OD1   1 ? 
ATOM   1624 N  ND2   . ASN A 1 203 ? 23.494  3.738   -1.713  1.000 71.507  0 203 ASN A ND2   1 ? 
ATOM   1625 N  N     . ALA A 1 204 ? 26.887  2.381   1.052   1.000 55.166  0 204 ALA A N     1 ? 
ATOM   1626 C  CA    . ALA A 1 204 ? 27.419  1.003   1.197   1.000 46.790  0 204 ALA A CA    1 ? 
ATOM   1627 C  C     . ALA A 1 204 ? 26.469  0.205   2.094   1.000 46.076  0 204 ALA A C     1 ? 
ATOM   1628 O  O     . ALA A 1 204 ? 26.245  -0.983  1.780   1.000 47.816  0 204 ALA A O     1 ? 
ATOM   1629 C  CB    . ALA A 1 204 ? 28.830  1.032   1.752   1.000 45.068  0 204 ALA A CB    1 ? 
ATOM   1630 N  N     . ALA A 1 205 ? 25.936  0.855   3.144   1.000 41.465  0 205 ALA A N     1 ? 
ATOM   1631 C  CA    . ALA A 1 205 ? 24.934  0.315   4.097   1.000 45.349  0 205 ALA A CA    1 ? 
ATOM   1632 C  C     . ALA A 1 205 ? 23.631  -0.019  3.368   1.000 44.645  0 205 ALA A C     1 ? 
ATOM   1633 O  O     . ALA A 1 205 ? 22.941  0.902   2.917   1.000 45.598  0 205 ALA A O     1 ? 
ATOM   1634 C  CB    . ALA A 1 205 ? 24.678  1.302   5.217   1.000 43.685  0 205 ALA A CB    1 ? 
ATOM   1635 N  N     . PRO A 1 206 ? 23.241  -1.327  3.296   1.000 42.059  0 206 PRO A N     1 ? 
ATOM   1636 C  CA    . PRO A 1 206 ? 21.972  -1.745  2.705   1.000 40.639  0 206 PRO A CA    1 ? 
ATOM   1637 C  C     . PRO A 1 206 ? 20.843  -1.175  3.568   1.000 39.214  0 206 PRO A C     1 ? 
ATOM   1638 O  O     . PRO A 1 206 ? 20.727  -1.508  4.743   1.000 46.026  0 206 PRO A O     1 ? 
ATOM   1639 C  CB    . PRO A 1 206 ? 21.990  -3.277  2.752   1.000 39.541  0 206 PRO A CB    1 ? 
ATOM   1640 C  CG    . PRO A 1 206 ? 22.882  -3.582  3.914   1.000 41.848  0 206 PRO A CG    1 ? 
ATOM   1641 C  CD    . PRO A 1 206 ? 23.931  -2.478  3.899   1.000 40.206  0 206 PRO A CD    1 ? 
ATOM   1642 N  N     . LEU A 1 207 ? 20.062  -0.299  2.972   1.000 33.225  0 207 LEU A N     1 ? 
ATOM   1643 C  CA    . LEU A 1 207 ? 19.122  0.541   3.714   1.000 35.500  0 207 LEU A CA    1 ? 
ATOM   1644 C  C     . LEU A 1 207 ? 18.092  -0.382  4.385   1.000 33.600  0 207 LEU A C     1 ? 
ATOM   1645 O  O     . LEU A 1 207 ? 18.008  -1.597  4.035   1.000 30.865  0 207 LEU A O     1 ? 
ATOM   1646 C  CB    . LEU A 1 207 ? 18.579  1.577   2.726   1.000 40.314  0 207 LEU A CB    1 ? 
ATOM   1647 C  CG    . LEU A 1 207 ? 19.684  2.463   2.123   1.000 38.954  0 207 LEU A CG    1 ? 
ATOM   1648 C  CD1   . LEU A 1 207 ? 19.142  3.367   1.024   1.000 40.896  0 207 LEU A CD1   1 ? 
ATOM   1649 C  CD2   . LEU A 1 207 ? 20.385  3.280   3.202   1.000 36.071  0 207 LEU A CD2   1 ? 
ATOM   1650 N  N     . GLY A 1 208 ? 17.512  0.094   5.476   1.000 29.741  0 208 GLY A N     1 ? 
ATOM   1651 C  CA    . GLY A 1 208 ? 16.445  -0.628  6.169   1.000 26.821  0 208 GLY A CA    1 ? 
ATOM   1652 C  C     . GLY A 1 208 ? 15.307  -0.869  5.215   1.000 25.664  0 208 GLY A C     1 ? 
ATOM   1653 O  O     . GLY A 1 208 ? 14.775  -1.966  5.215   1.000 24.058  0 208 GLY A O     1 ? 
ATOM   1654 N  N     . ILE A 1 209 ? 14.967  0.148   4.424   1.000 27.576  0 209 ILE A N     1 ? 
ATOM   1655 C  CA    . ILE A 1 209 ? 13.803  0.107   3.500   1.000 27.224  0 209 ILE A CA    1 ? 
ATOM   1656 C  C     . ILE A 1 209 ? 13.993  -1.094  2.568   1.000 23.017  0 209 ILE A C     1 ? 
ATOM   1657 O  O     . ILE A 1 209 ? 13.031  -1.874  2.373   1.000 22.321  0 209 ILE A O     1 ? 
ATOM   1658 C  CB    . ILE A 1 209 ? 13.642  1.450   2.754   1.000 28.130  0 209 ILE A CB    1 ? 
ATOM   1659 C  CG1   . ILE A 1 209 ? 12.396  1.454   1.875   1.000 31.254  0 209 ILE A CG1   1 ? 
ATOM   1660 C  CG2   . ILE A 1 209 ? 14.885  1.801   1.948   1.000 30.553  0 209 ILE A CG2   1 ? 
ATOM   1661 C  CD1   . ILE A 1 209 ? 11.124  1.125   2.607   1.000 31.089  0 209 ILE A CD1   1 ? 
ATOM   1662 N  N     . GLY A 1 210 ? 15.205  -1.267  2.064   1.000 19.922  0 210 GLY A N     1 ? 
ATOM   1663 C  CA    . GLY A 1 210 ? 15.574  -2.350  1.138   1.000 19.833  0 210 GLY A CA    1 ? 
ATOM   1664 C  C     . GLY A 1 210 ? 15.464  -3.739  1.751   1.000 18.483  0 210 GLY A C     1 ? 
ATOM   1665 O  O     . GLY A 1 210 ? 14.949  -4.632  1.107   1.000 15.480  0 210 GLY A O     1 ? 
ATOM   1666 N  N     . LEU A 1 211 ? 15.989  -3.925  2.950   1.000 18.615  0 211 LEU A N     1 ? 
ATOM   1667 C  CA    . LEU A 1 211 ? 15.843  -5.189  3.700   1.000 18.888  0 211 LEU A CA    1 ? 
ATOM   1668 C  C     . LEU A 1 211 ? 14.380  -5.418  4.050   1.000 17.333  0 211 LEU A C     1 ? 
ATOM   1669 O  O     . LEU A 1 211 ? 13.990  -6.606  4.124   1.000 15.049  0 211 LEU A O     1 ? 
ATOM   1670 C  CB    . LEU A 1 211 ? 16.701  -5.128  4.959   1.000 21.848  0 211 LEU A CB    1 ? 
ATOM   1671 C  CG    . LEU A 1 211 ? 18.201  -5.141  4.689   1.000 23.128  0 211 LEU A CG    1 ? 
ATOM   1672 C  CD1   . LEU A 1 211 ? 18.959  -4.648  5.910   1.000 26.374  0 211 LEU A CD1   1 ? 
ATOM   1673 C  CD2   . LEU A 1 211 ? 18.659  -6.529  4.271   1.000 23.371  0 211 LEU A CD2   1 ? 
ATOM   1674 N  N     . THR A 1 212 ? 13.614  -4.345  4.283   1.000 16.925  0 212 THR A N     1 ? 
ATOM   1675 C  CA    . THR A 1 212 ? 12.168  -4.456  4.615   1.000 16.485  0 212 THR A CA    1 ? 
ATOM   1676 C  C     . THR A 1 212 ? 11.452  -4.976  3.358   1.000 16.308  0 212 THR A C     1 ? 
ATOM   1677 O  O     . THR A 1 212 ? 10.617  -5.889  3.451   1.000 15.447  0 212 THR A O     1 ? 
ATOM   1678 C  CB    . THR A 1 212 ? 11.642  -3.127  5.183   1.000 15.946  0 212 THR A CB    1 ? 
ATOM   1679 O  OG1   . THR A 1 212 ? 12.374  -2.838  6.357   1.000 14.150  0 212 THR A OG1   1 ? 
ATOM   1680 C  CG2   . THR A 1 212 ? 10.189  -3.127  5.593   1.000 15.638  0 212 THR A CG2   1 ? 
ATOM   1681 N  N     . ALA A 1 213 ? 11.742  -4.389  2.204   1.000 15.747  0 213 ALA A N     1 ? 
ATOM   1682 C  CA    . ALA A 1 213 ? 11.066  -4.732  0.939   1.000 15.834  0 213 ALA A CA    1 ? 
ATOM   1683 C  C     . ALA A 1 213 ? 11.501  -6.138  0.527   1.000 15.368  0 213 ALA A C     1 ? 
ATOM   1684 O  O     . ALA A 1 213 ? 10.634  -6.911  0.129   1.000 14.782  0 213 ALA A O     1 ? 
ATOM   1685 C  CB    . ALA A 1 213 ? 11.341  -3.678  -0.112  1.000 16.392  0 213 ALA A CB    1 ? 
ATOM   1686 N  N     . ALA A 1 214 ? 12.774  -6.509  0.751   1.000 14.904  0 214 ALA A N     1 ? 
ATOM   1687 C  CA    . ALA A 1 214 ? 13.306  -7.872  0.484   1.000 14.538  0 214 ALA A CA    1 ? 
ATOM   1688 C  C     . ALA A 1 214 ? 12.482  -8.895  1.288   1.000 14.806  0 214 ALA A C     1 ? 
ATOM   1689 O  O     . ALA A 1 214 ? 12.110  -9.937  0.743   1.000 14.483  0 214 ALA A O     1 ? 
ATOM   1690 C  CB    . ALA A 1 214 ? 14.767  -7.954  0.876   1.000 13.829  0 214 ALA A CB    1 ? 
ATOM   1691 N  N     . ALA A 1 215 ? 12.195  -8.567  2.547   1.000 13.248  0 215 ALA A N     1 ? 
ATOM   1692 C  CA    . ALA A 1 215 ? 11.442  -9.430  3.467   1.000 13.380  0 215 ALA A CA    1 ? 
ATOM   1693 C  C     . ALA A 1 215 ? 10.010  -9.572  2.951   1.000 12.780  0 215 ALA A C     1 ? 
ATOM   1694 O  O     . ALA A 1 215 ? 9.491   -10.728 2.874   1.000 12.794  0 215 ALA A O     1 ? 
ATOM   1695 C  CB    . ALA A 1 215 ? 11.559  -8.863  4.855   1.000 13.029  0 215 ALA A CB    1 ? 
ATOM   1696 N  N     . TYR A 1 216 ? 9.430   -8.467  2.483   1.000 14.010  0 216 TYR A N     1 ? 
ATOM   1697 C  CA    . TYR A 1 216 ? 8.075   -8.466  1.896   1.000 14.297  0 216 TYR A CA    1 ? 
ATOM   1698 C  C     . TYR A 1 216 ? 8.017   -9.513  0.782   1.000 15.863  0 216 TYR A C     1 ? 
ATOM   1699 O  O     . TYR A 1 216 ? 7.103   -10.407 0.804   1.000 14.380  0 216 TYR A O     1 ? 
ATOM   1700 C  CB    . TYR A 1 216 ? 7.691   -7.065  1.405   1.000 15.196  0 216 TYR A CB    1 ? 
ATOM   1701 C  CG    . TYR A 1 216 ? 6.458   -7.076  0.547   1.000 15.474  0 216 TYR A CG    1 ? 
ATOM   1702 C  CD1   . TYR A 1 216 ? 5.199   -7.101  1.124   1.000 15.820  0 216 TYR A CD1   1 ? 
ATOM   1703 C  CD2   . TYR A 1 216 ? 6.544   -7.180  -0.837  1.000 15.950  0 216 TYR A CD2   1 ? 
ATOM   1704 C  CE1   . TYR A 1 216 ? 4.051   -7.165  0.349   1.000 15.314  0 216 TYR A CE1   1 ? 
ATOM   1705 C  CE2   . TYR A 1 216 ? 5.409   -7.264  -1.628  1.000 16.260  0 216 TYR A CE2   1 ? 
ATOM   1706 C  CZ    . TYR A 1 216 ? 4.158   -7.224  -1.025  1.000 17.232  0 216 TYR A CZ    1 ? 
ATOM   1707 O  OH    . TYR A 1 216 ? 3.030   -7.264  -1.788  1.000 20.417  0 216 TYR A OH    1 ? 
ATOM   1708 N  N     . TRP A 1 217 ? 8.969   -9.460  -0.164  1.000 17.273  0 217 TRP A N     1 ? 
ATOM   1709 C  CA    . TRP A 1 217 ? 8.996   -10.405 -1.315  1.000 17.537  0 217 TRP A CA    1 ? 
ATOM   1710 C  C     . TRP A 1 217 ? 9.277   -11.856 -0.877  1.000 19.593  0 217 TRP A C     1 ? 
ATOM   1711 O  O     . TRP A 1 217 ? 8.635   -12.794 -1.438  1.000 21.254  0 217 TRP A O     1 ? 
ATOM   1712 C  CB    . TRP A 1 217 ? 9.998   -9.943  -2.381  1.000 19.385  0 217 TRP A CB    1 ? 
ATOM   1713 C  CG    . TRP A 1 217 ? 9.613   -8.647  -3.027  1.000 20.270  0 217 TRP A CG    1 ? 
ATOM   1714 C  CD1   . TRP A 1 217 ? 10.246  -7.449  -2.888  1.000 20.733  0 217 TRP A CD1   1 ? 
ATOM   1715 C  CD2   . TRP A 1 217 ? 8.476   -8.404  -3.865  1.000 20.494  0 217 TRP A CD2   1 ? 
ATOM   1716 N  NE1   . TRP A 1 217 ? 9.622   -6.494  -3.630  1.000 22.796  0 217 TRP A NE1   1 ? 
ATOM   1717 C  CE2   . TRP A 1 217 ? 8.521   -7.040  -4.228  1.000 21.954  0 217 TRP A CE2   1 ? 
ATOM   1718 C  CE3   . TRP A 1 217 ? 7.430   -9.201  -4.350  1.000 19.902  0 217 TRP A CE3   1 ? 
ATOM   1719 C  CZ2   . TRP A 1 217 ? 7.558   -6.451  -5.048  1.000 22.387  0 217 TRP A CZ2   1 ? 
ATOM   1720 C  CZ3   . TRP A 1 217 ? 6.501   -8.630  -5.201  1.000 22.625  0 217 TRP A CZ3   1 ? 
ATOM   1721 C  CH2   . TRP A 1 217 ? 6.549   -7.268  -5.522  1.000 22.212  0 217 TRP A CH2   1 ? 
ATOM   1722 N  N     . TRP A 1 218 ? 10.227  -12.074 0.029   1.000 17.418  0 218 TRP A N     1 ? 
ATOM   1723 C  CA    . TRP A 1 218 ? 10.970  -13.358 0.104   1.000 15.930  0 218 TRP A CA    1 ? 
ATOM   1724 C  C     . TRP A 1 218 ? 10.908  -13.994 1.490   1.000 16.242  0 218 TRP A C     1 ? 
ATOM   1725 O  O     . TRP A 1 218 ? 11.222  -15.199 1.586   1.000 17.041  0 218 TRP A O     1 ? 
ATOM   1726 C  CB    . TRP A 1 218 ? 12.410  -13.140 -0.331  1.000 16.638  0 218 TRP A CB    1 ? 
ATOM   1727 C  CG    . TRP A 1 218 ? 12.525  -12.707 -1.764  1.000 17.697  0 218 TRP A CG    1 ? 
ATOM   1728 C  CD1   . TRP A 1 218 ? 11.799  -13.195 -2.804  1.000 17.594  0 218 TRP A CD1   1 ? 
ATOM   1729 C  CD2   . TRP A 1 218 ? 13.435  -11.738 -2.330  1.000 17.725  0 218 TRP A CD2   1 ? 
ATOM   1730 N  NE1   . TRP A 1 218 ? 12.159  -12.576 -3.967  1.000 19.510  0 218 TRP A NE1   1 ? 
ATOM   1731 C  CE2   . TRP A 1 218 ? 13.160  -11.675 -3.710  1.000 18.108  0 218 TRP A CE2   1 ? 
ATOM   1732 C  CE3   . TRP A 1 218 ? 14.443  -10.903 -1.820  1.000 18.417  0 218 TRP A CE3   1 ? 
ATOM   1733 C  CZ2   . TRP A 1 218 ? 13.851  -10.817 -4.576  1.000 18.809  0 218 TRP A CZ2   1 ? 
ATOM   1734 C  CZ3   . TRP A 1 218 ? 15.120  -10.051 -2.674  1.000 18.386  0 218 TRP A CZ3   1 ? 
ATOM   1735 C  CH2   . TRP A 1 218 ? 14.843  -10.030 -4.039  1.000 17.818  0 218 TRP A CH2   1 ? 
ATOM   1736 N  N     . PHE A 1 219 ? 10.554  -13.254 2.537   1.000 16.451  0 219 PHE A N     1 ? 
ATOM   1737 C  CA    . PHE A 1 219 ? 10.482  -13.850 3.884   1.000 16.891  0 219 PHE A CA    1 ? 
ATOM   1738 C  C     . PHE A 1 219 ? 9.526   -15.029 3.833   1.000 18.955  0 219 PHE A C     1 ? 
ATOM   1739 O  O     . PHE A 1 219 ? 8.437   -14.876 3.200   1.000 20.874  0 219 PHE A O     1 ? 
ATOM   1740 C  CB    . PHE A 1 219 ? 9.975   -12.890 4.947   1.000 16.508  0 219 PHE A CB    1 ? 
ATOM   1741 C  CG    . PHE A 1 219 ? 9.868   -13.542 6.308   1.000 16.379  0 219 PHE A CG    1 ? 
ATOM   1742 C  CD1   . PHE A 1 219 ? 10.984  -13.728 7.090   1.000 16.850  0 219 PHE A CD1   1 ? 
ATOM   1743 C  CD2   . PHE A 1 219 ? 8.647   -13.988 6.791   1.000 15.807  0 219 PHE A CD2   1 ? 
ATOM   1744 C  CE1   . PHE A 1 219 ? 10.874  -14.327 8.337   1.000 17.614  0 219 PHE A CE1   1 ? 
ATOM   1745 C  CE2   . PHE A 1 219 ? 8.534   -14.549 8.037   1.000 15.882  0 219 PHE A CE2   1 ? 
ATOM   1746 C  CZ    . PHE A 1 219 ? 9.657   -14.760 8.796   1.000 16.908  0 219 PHE A CZ    1 ? 
ATOM   1747 N  N     . GLN A 1 220 ? 9.908   -16.130 4.491   1.000 17.309  0 220 GLN A N     1 ? 
ATOM   1748 C  CA    . GLN A 1 220 ? 9.034   -17.295 4.743   1.000 17.554  0 220 GLN A CA    1 ? 
ATOM   1749 C  C     . GLN A 1 220 ? 9.103   -17.659 6.230   1.000 16.581  0 220 GLN A C     1 ? 
ATOM   1750 O  O     . GLN A 1 220 ? 10.228  -17.712 6.810   1.000 15.148  0 220 GLN A O     1 ? 
ATOM   1751 C  CB    . GLN A 1 220 ? 9.418   -18.455 3.829   1.000 19.118  0 220 GLN A CB    1 ? 
ATOM   1752 C  CG    . GLN A 1 220 ? 9.198   -18.150 2.359   1.000 22.319  0 220 GLN A CG    1 ? 
ATOM   1753 C  CD    . GLN A 1 220 ? 7.745   -17.896 2.033   1.000 26.246  0 220 GLN A CD    1 ? 
ATOM   1754 O  OE1   . GLN A 1 220 ? 6.842   -18.134 2.835   1.000 33.530  0 220 GLN A OE1   1 ? 
ATOM   1755 N  NE2   . GLN A 1 220 ? 7.503   -17.379 0.845   1.000 29.209  0 220 GLN A NE2   1 ? 
ATOM   1756 N  N     . VAL A 1 221 ? 7.936   -17.825 6.852   1.000 15.892  0 221 VAL A N     1 ? 
ATOM   1757 C  CA    . VAL A 1 221 ? 7.813   -18.319 8.253   1.000 16.312  0 221 VAL A CA    1 ? 
ATOM   1758 C  C     . VAL A 1 221 ? 8.571   -19.643 8.378   1.000 15.788  0 221 VAL A C     1 ? 
ATOM   1759 O  O     . VAL A 1 221 ? 8.574   -20.452 7.415   1.000 17.786  0 221 VAL A O     1 ? 
ATOM   1760 C  CB    . VAL A 1 221 ? 6.344   -18.522 8.647   1.000 18.138  0 221 VAL A CB    1 ? 
ATOM   1761 C  CG1   . VAL A 1 221 ? 6.207   -19.234 9.971   1.000 18.064  0 221 VAL A CG1   1 ? 
ATOM   1762 C  CG2   . VAL A 1 221 ? 5.594   -17.203 8.663   1.000 20.078  0 221 VAL A CG2   1 ? 
ATOM   1763 N  N     . SER A 1 222 ? 9.191   -19.857 9.525   1.000 15.633  0 222 SER A N     1 ? 
ATOM   1764 C  CA    . SER A 1 222 ? 9.739   -21.157 9.942   1.000 14.725  0 222 SER A CA    1 ? 
ATOM   1765 C  C     . SER A 1 222 ? 9.194   -21.463 11.333  1.000 15.032  0 222 SER A C     1 ? 
ATOM   1766 O  O     . SER A 1 222 ? 9.610   -20.831 12.299  1.000 12.846  0 222 SER A O     1 ? 
ATOM   1767 C  CB    . SER A 1 222 ? 11.230  -21.182 9.884   1.000 14.932  0 222 SER A CB    1 ? 
ATOM   1768 O  OG    . SER A 1 222 ? 11.718  -22.416 10.399  1.000 14.398  0 222 SER A OG    1 ? 
ATOM   1769 N  N     . LYS A 1 223 ? 8.261   -22.400 11.386  1.000 15.981  0 223 LYS A N     1 ? 
ATOM   1770 C  CA    . LYS A 1 223 ? 7.657   -22.916 12.616  1.000 18.728  0 223 LYS A CA    1 ? 
ATOM   1771 C  C     . LYS A 1 223 ? 7.403   -24.412 12.448  1.000 21.802  0 223 LYS A C     1 ? 
ATOM   1772 O  O     . LYS A 1 223 ? 7.487   -24.947 11.315  1.000 21.565  0 223 LYS A O     1 ? 
ATOM   1773 C  CB    . LYS A 1 223 ? 6.366   -22.157 12.914  1.000 18.361  0 223 LYS A CB    1 ? 
ATOM   1774 C  CG    . LYS A 1 223 ? 5.304   -22.315 11.844  1.000 18.346  0 223 LYS A CG    1 ? 
ATOM   1775 C  CD    . LYS A 1 223 ? 4.013   -21.608 12.213  1.000 18.232  0 223 LYS A CD    1 ? 
ATOM   1776 C  CE    . LYS A 1 223 ? 3.021   -21.646 11.086  1.000 16.400  0 223 LYS A CE    1 ? 
ATOM   1777 N  NZ    . LYS A 1 223 ? 1.951   -20.655 11.299  1.000 17.937  0 223 LYS A NZ    1 ? 
ATOM   1778 N  N     . ARG A 1 224 ? 7.163   -25.074 13.561  1.000 24.316  0 224 ARG A N     1 ? 
ATOM   1779 C  CA    . ARG A 1 224 ? 6.722   -26.484 13.601  1.000 29.010  0 224 ARG A CA    1 ? 
ATOM   1780 C  C     . ARG A 1 224 ? 5.495   -26.557 14.493  1.000 28.823  0 224 ARG A C     1 ? 
ATOM   1781 O  O     . ARG A 1 224 ? 5.552   -25.967 15.572  1.000 27.247  0 224 ARG A O     1 ? 
ATOM   1782 C  CB    . ARG A 1 224 ? 7.798   -27.361 14.231  1.000 35.918  0 224 ARG A CB    1 ? 
ATOM   1783 C  CG    . ARG A 1 224 ? 8.894   -27.804 13.282  1.000 41.022  0 224 ARG A CG    1 ? 
ATOM   1784 C  CD    . ARG A 1 224 ? 9.860   -28.698 14.042  1.000 48.522  0 224 ARG A CD    1 ? 
ATOM   1785 N  NE    . ARG A 1 224 ? 9.199   -29.848 14.658  1.000 54.230  0 224 ARG A NE    1 ? 
ATOM   1786 C  CZ    . ARG A 1 224 ? 9.819   -30.816 15.326  1.000 62.607  0 224 ARG A CZ    1 ? 
ATOM   1787 N  NH1   . ARG A 1 224 ? 11.131  -30.784 15.494  1.000 67.518  0 224 ARG A NH1   1 ? 
ATOM   1788 N  NH2   . ARG A 1 224 ? 9.119   -31.817 15.832  1.000 71.151  0 224 ARG A NH2   1 ? 
ATOM   1789 N  N     . THR A 1 225 ? 4.481   -27.303 14.058  1.000 30.395  0 225 THR A N     1 ? 
ATOM   1790 C  CA    . THR A 1 225 ? 3.280   -27.694 14.830  1.000 30.616  0 225 THR A CA    1 ? 
ATOM   1791 C  C     . THR A 1 225 ? 3.377   -29.180 15.240  1.000 29.580  0 225 THR A C     1 ? 
ATOM   1792 O  O     . THR A 1 225 ? 3.437   -30.050 14.345  1.000 23.793  0 225 THR A O     1 ? 
ATOM   1793 C  CB    . THR A 1 225 ? 2.036   -27.411 13.984  1.000 34.281  0 225 THR A CB    1 ? 
ATOM   1794 O  OG1   . THR A 1 225 ? 2.138   -26.038 13.603  1.000 38.215  0 225 THR A OG1   1 ? 
ATOM   1795 C  CG2   . THR A 1 225 ? 0.733   -27.667 14.713  1.000 34.111  0 225 THR A CG2   1 ? 
ATOM   1796 N  N     . ASP A 1 226 ? 3.382   -29.474 16.538  1.000 30.803  0 226 ASP A N     1 ? 
ATOM   1797 C  CA    . ASP A 1 226 ? 3.398   -30.878 17.037  1.000 36.094  0 226 ASP A CA    1 ? 
ATOM   1798 C  C     . ASP A 1 226 ? 2.132   -31.609 16.557  1.000 41.412  0 226 ASP A C     1 ? 
ATOM   1799 O  O     . ASP A 1 226 ? 1.012   -31.160 16.826  1.000 41.015  0 226 ASP A O     1 ? 
ATOM   1800 C  CB    . ASP A 1 226 ? 3.508   -30.952 18.551  1.000 35.680  0 226 ASP A CB    1 ? 
ATOM   1801 C  CG    . ASP A 1 226 ? 3.618   -32.390 19.050  1.000 39.429  0 226 ASP A CG    1 ? 
ATOM   1802 O  OD1   . ASP A 1 226 ? 2.572   -33.100 19.059  1.000 36.315  0 226 ASP A OD1   1 ? 
ATOM   1803 O  OD2   . ASP A 1 226 ? 4.747   -32.796 19.412  1.000 39.399  0 226 ASP A OD2   1 ? 
ATOM   1804 N  N     . PRO A 1 227 ? 2.273   -32.732 15.808  1.000 36.854  0 227 PRO A N     1 ? 
ATOM   1805 C  CA    . PRO A 1 227 ? 1.127   -33.508 15.327  1.000 40.505  0 227 PRO A CA    1 ? 
ATOM   1806 C  C     . PRO A 1 227 ? 0.009   -33.757 16.350  1.000 43.024  0 227 PRO A C     1 ? 
ATOM   1807 O  O     . PRO A 1 227 ? -1.148  -33.725 15.955  1.000 46.517  0 227 PRO A O     1 ? 
ATOM   1808 C  CB    . PRO A 1 227 ? 1.775   -34.854 14.975  1.000 43.919  0 227 PRO A CB    1 ? 
ATOM   1809 C  CG    . PRO A 1 227 ? 3.168   -34.470 14.492  1.000 41.397  0 227 PRO A CG    1 ? 
ATOM   1810 C  CD    . PRO A 1 227 ? 3.559   -33.306 15.373  1.000 41.257  0 227 PRO A CD    1 ? 
ATOM   1811 N  N     . VAL A 1 228 ? 0.373   -33.952 17.624  1.000 38.227  0 228 VAL A N     1 ? 
ATOM   1812 C  CA    . VAL A 1 228 ? -0.529  -34.485 18.679  1.000 38.230  0 228 VAL A CA    1 ? 
ATOM   1813 C  C     . VAL A 1 228 ? -0.973  -33.370 19.623  1.000 37.698  0 228 VAL A C     1 ? 
ATOM   1814 O  O     . VAL A 1 228 ? -2.118  -33.455 20.086  1.000 42.174  0 228 VAL A O     1 ? 
ATOM   1815 C  CB    . VAL A 1 228 ? 0.132   -35.629 19.475  1.000 39.171  0 228 VAL A CB    1 ? 
ATOM   1816 C  CG1   . VAL A 1 228 ? -0.897  -36.361 20.324  1.000 38.437  0 228 VAL A CG1   1 ? 
ATOM   1817 C  CG2   . VAL A 1 228 ? 0.893   -36.592 18.574  1.000 38.681  0 228 VAL A CG2   1 ? 
ATOM   1818 N  N     . SER A 1 229 ? -0.102  -32.423 19.983  1.000 35.413  0 229 SER A N     1 ? 
ATOM   1819 C  CA    . SER A 1 229 ? -0.450  -31.345 20.947  1.000 33.306  0 229 SER A CA    1 ? 
ATOM   1820 C  C     . SER A 1 229 ? -0.913  -30.087 20.201  1.000 31.885  0 229 SER A C     1 ? 
ATOM   1821 O  O     . SER A 1 229 ? -1.498  -29.215 20.878  1.000 28.706  0 229 SER A O     1 ? 
ATOM   1822 C  CB    . SER A 1 229 ? 0.695   -31.011 21.865  1.000 33.456  0 229 SER A CB    1 ? 
ATOM   1823 O  OG    . SER A 1 229 ? 1.716   -30.342 21.148  1.000 32.639  0 229 SER A OG    1 ? 
ATOM   1824 N  N     . GLN A 1 230 ? -0.581  -29.980 18.903  1.000 29.600  0 230 GLN A N     1 ? 
ATOM   1825 C  CA    . GLN A 1 230 ? -0.721  -28.760 18.052  1.000 29.396  0 230 GLN A CA    1 ? 
ATOM   1826 C  C     . GLN A 1 230 ? 0.082   -27.583 18.652  1.000 28.699  0 230 GLN A C     1 ? 
ATOM   1827 O  O     . GLN A 1 230 ? -0.195  -26.418 18.293  1.000 29.231  0 230 GLN A O     1 ? 
ATOM   1828 C  CB    . GLN A 1 230 ? -2.201  -28.403 17.855  1.000 27.429  0 230 GLN A CB    1 ? 
ATOM   1829 C  CG    . GLN A 1 230 ? -2.971  -29.403 16.995  1.000 27.194  0 230 GLN A CG    1 ? 
ATOM   1830 C  CD    . GLN A 1 230 ? -4.423  -29.041 16.783  1.000 28.999  0 230 GLN A CD    1 ? 
ATOM   1831 O  OE1   . GLN A 1 230 ? -4.982  -28.194 17.467  1.000 26.666  0 230 GLN A OE1   1 ? 
ATOM   1832 N  NE2   . GLN A 1 230 ? -5.040  -29.658 15.789  1.000 29.464  0 230 GLN A NE2   1 ? 
ATOM   1833 N  N     . ASN A 1 231 ? 1.049   -27.854 19.529  1.000 27.995  0 231 ASN A N     1 ? 
ATOM   1834 C  CA    . ASN A 1 231 ? 1.940   -26.808 20.086  1.000 26.066  0 231 ASN A CA    1 ? 
ATOM   1835 C  C     . ASN A 1 231 ? 2.830   -26.294 18.942  1.000 24.851  0 231 ASN A C     1 ? 
ATOM   1836 O  O     . ASN A 1 231 ? 3.369   -27.112 18.146  1.000 24.774  0 231 ASN A O     1 ? 
ATOM   1837 C  CB    . ASN A 1 231 ? 2.730   -27.301 21.301  1.000 27.750  0 231 ASN A CB    1 ? 
ATOM   1838 C  CG    . ASN A 1 231 ? 3.686   -26.256 21.840  1.000 30.965  0 231 ASN A CG    1 ? 
ATOM   1839 O  OD1   . ASN A 1 231 ? 3.267   -25.294 22.477  1.000 34.825  0 231 ASN A OD1   1 ? 
ATOM   1840 N  ND2   . ASN A 1 231 ? 4.973   -26.422 21.575  1.000 31.049  0 231 ASN A ND2   1 ? 
ATOM   1841 N  N     . VAL A 1 232 ? 2.950   -24.974 18.845  1.000 24.999  0 232 VAL A N     1 ? 
ATOM   1842 C  CA    . VAL A 1 232 ? 3.678   -24.278 17.753  1.000 24.668  0 232 VAL A CA    1 ? 
ATOM   1843 C  C     . VAL A 1 232 ? 5.005   -23.737 18.293  1.000 24.566  0 232 VAL A C     1 ? 
ATOM   1844 O  O     . VAL A 1 232 ? 4.980   -22.998 19.304  1.000 25.461  0 232 VAL A O     1 ? 
ATOM   1845 C  CB    . VAL A 1 232 ? 2.818   -23.159 17.158  1.000 25.120  0 232 VAL A CB    1 ? 
ATOM   1846 C  CG1   . VAL A 1 232 ? 3.540   -22.463 16.008  1.000 24.969  0 232 VAL A CG1   1 ? 
ATOM   1847 C  CG2   . VAL A 1 232 ? 1.471   -23.679 16.697  1.000 25.039  0 232 VAL A CG2   1 ? 
ATOM   1848 N  N     . THR A 1 233 ? 6.115   -24.027 17.611  1.000 22.770  0 233 THR A N     1 ? 
ATOM   1849 C  CA    . THR A 1 233 ? 7.444   -23.464 17.960  1.000 22.502  0 233 THR A CA    1 ? 
ATOM   1850 C  C     . THR A 1 233 ? 8.056   -22.779 16.739  1.000 21.401  0 233 THR A C     1 ? 
ATOM   1851 O  O     . THR A 1 233 ? 8.026   -23.356 15.645  1.000 25.419  0 233 THR A O     1 ? 
ATOM   1852 C  CB    . THR A 1 233 ? 8.394   -24.543 18.482  1.000 24.632  0 233 THR A CB    1 ? 
ATOM   1853 O  OG1   . THR A 1 233 ? 8.392   -25.587 17.503  1.000 26.138  0 233 THR A OG1   1 ? 
ATOM   1854 C  CG2   . THR A 1 233 ? 7.994   -25.054 19.853  1.000 25.205  0 233 THR A CG2   1 ? 
ATOM   1855 N  N     . TYR A 1 234 ? 8.634   -21.605 16.937  1.000 18.330  0 234 TYR A N     1 ? 
ATOM   1856 C  CA    . TYR A 1 234 ? 9.243   -20.814 15.835  1.000 18.245  0 234 TYR A CA    1 ? 
ATOM   1857 C  C     . TYR A 1 234 ? 10.749  -21.083 15.854  1.000 16.479  0 234 TYR A C     1 ? 
ATOM   1858 O  O     . TYR A 1 234 ? 11.286  -21.438 16.893  1.000 15.709  0 234 TYR A O     1 ? 
ATOM   1859 C  CB    . TYR A 1 234 ? 8.828   -19.348 15.959  1.000 16.733  0 234 TYR A CB    1 ? 
ATOM   1860 C  CG    . TYR A 1 234 ? 7.426   -19.094 15.475  1.000 15.809  0 234 TYR A CG    1 ? 
ATOM   1861 C  CD1   . TYR A 1 234 ? 6.335   -19.258 16.305  1.000 16.210  0 234 TYR A CD1   1 ? 
ATOM   1862 C  CD2   . TYR A 1 234 ? 7.185   -18.720 14.165  1.000 17.373  0 234 TYR A CD2   1 ? 
ATOM   1863 C  CE1   . TYR A 1 234 ? 5.040   -19.034 15.843  1.000 18.239  0 234 TYR A CE1   1 ? 
ATOM   1864 C  CE2   . TYR A 1 234 ? 5.902   -18.485 13.685  1.000 15.682  0 234 TYR A CE2   1 ? 
ATOM   1865 C  CZ    . TYR A 1 234 ? 4.819   -18.621 14.533  1.000 16.059  0 234 TYR A CZ    1 ? 
ATOM   1866 O  OH    . TYR A 1 234 ? 3.560   -18.449 14.032  1.000 14.877  0 234 TYR A OH    1 ? 
ATOM   1867 N  N     . ASP A 1 235 ? 11.353  -21.003 14.682  1.000 16.633  0 235 ASP A N     1 ? 
ATOM   1868 C  CA    . ASP A 1 235 ? 12.794  -21.241 14.430  1.000 17.647  0 235 ASP A CA    1 ? 
ATOM   1869 C  C     . ASP A 1 235 ? 13.315  -20.052 13.645  1.000 15.068  0 235 ASP A C     1 ? 
ATOM   1870 O  O     . ASP A 1 235 ? 13.307  -20.116 12.417  1.000 15.988  0 235 ASP A O     1 ? 
ATOM   1871 C  CB    . ASP A 1 235 ? 13.011  -22.547 13.690  1.000 17.982  0 235 ASP A CB    1 ? 
ATOM   1872 C  CG    . ASP A 1 235 ? 14.464  -22.952 13.620  1.000 18.742  0 235 ASP A CG    1 ? 
ATOM   1873 O  OD1   . ASP A 1 235 ? 15.367  -22.075 13.730  1.000 17.632  0 235 ASP A OD1   1 ? 
ATOM   1874 O  OD2   . ASP A 1 235 ? 14.670  -24.123 13.454  1.000 21.672  0 235 ASP A OD2   1 ? 
ATOM   1875 N  N     . ASP A 1 236 ? 13.647  -18.987 14.362  1.000 15.785  0 236 ASP A N     1 ? 
ATOM   1876 C  CA    . ASP A 1 236 ? 14.123  -17.700 13.792  1.000 14.880  0 236 ASP A CA    1 ? 
ATOM   1877 C  C     . ASP A 1 236 ? 15.449  -17.926 13.048  1.000 13.612  0 236 ASP A C     1 ? 
ATOM   1878 O  O     . ASP A 1 236 ? 15.707  -17.243 12.051  1.000 12.881  0 236 ASP A O     1 ? 
ATOM   1879 C  CB    . ASP A 1 236 ? 14.264  -16.639 14.877  1.000 13.746  0 236 ASP A CB    1 ? 
ATOM   1880 C  CG    . ASP A 1 236 ? 12.968  -16.057 15.403  1.000 14.386  0 236 ASP A CG    1 ? 
ATOM   1881 O  OD1   . ASP A 1 236 ? 11.913  -16.655 15.167  1.000 14.862  0 236 ASP A OD1   1 ? 
ATOM   1882 O  OD2   . ASP A 1 236 ? 13.039  -15.018 16.101  1.000 12.945  0 236 ASP A OD2   1 ? 
ATOM   1883 N  N     . ARG A 1 237 ? 16.291  -18.832 13.508  1.000 14.338  0 237 ARG A N     1 ? 
ATOM   1884 C  CA    . ARG A 1 237 ? 17.580  -19.142 12.830  1.000 14.680  0 237 ARG A CA    1 ? 
ATOM   1885 C  C     . ARG A 1 237 ? 17.275  -19.713 11.444  1.000 14.600  0 237 ARG A C     1 ? 
ATOM   1886 O  O     . ARG A 1 237 ? 17.912  -19.298 10.440  1.000 16.223  0 237 ARG A O     1 ? 
ATOM   1887 C  CB    . ARG A 1 237 ? 18.421  -20.153 13.620  1.000 16.106  0 237 ARG A CB    1 ? 
ATOM   1888 C  CG    . ARG A 1 237 ? 19.885  -20.210 13.176  1.000 17.393  0 237 ARG A CG    1 ? 
ATOM   1889 C  CD    . ARG A 1 237 ? 20.482  -21.596 13.468  1.000 19.040  0 237 ARG A CD    1 ? 
ATOM   1890 N  NE    . ARG A 1 237 ? 19.616  -22.666 12.989  1.000 19.493  0 237 ARG A NE    1 ? 
ATOM   1891 C  CZ    . ARG A 1 237 ? 19.497  -22.983 11.706  1.000 20.336  0 237 ARG A CZ    1 ? 
ATOM   1892 N  NH1   . ARG A 1 237 ? 20.272  -22.405 10.807  1.000 19.556  0 237 ARG A NH1   1 ? 
ATOM   1893 N  NH2   . ARG A 1 237 ? 18.599  -23.860 11.315  1.000 20.309  0 237 ARG A NH2   1 ? 
ATOM   1894 N  N     . ASP A 1 238 ? 16.341  -20.656 11.374  1.000 13.110  0 238 ASP A N     1 ? 
ATOM   1895 C  CA    . ASP A 1 238 ? 15.996  -21.311 10.097  1.000 12.652  0 238 ASP A CA    1 ? 
ATOM   1896 C  C     . ASP A 1 238 ? 15.306  -20.268 9.189   1.000 12.297  0 238 ASP A C     1 ? 
ATOM   1897 O  O     . ASP A 1 238 ? 15.619  -20.199 7.993   1.000 10.548  0 238 ASP A O     1 ? 
ATOM   1898 C  CB    . ASP A 1 238 ? 15.139  -22.554 10.377  1.000 14.135  0 238 ASP A CB    1 ? 
ATOM   1899 C  CG    . ASP A 1 238 ? 14.736  -23.218 9.087   1.000 16.078  0 238 ASP A CG    1 ? 
ATOM   1900 O  OD1   . ASP A 1 238 ? 15.664  -23.597 8.298   1.000 14.442  0 238 ASP A OD1   1 ? 
ATOM   1901 O  OD2   . ASP A 1 238 ? 13.524  -23.180 8.798   1.000 18.753  0 238 ASP A OD2   1 ? 
ATOM   1902 N  N     . ALA A 1 239 ? 14.413  -19.439 9.732   1.000 12.026  0 239 ALA A N     1 ? 
ATOM   1903 C  CA    . ALA A 1 239 ? 13.684  -18.429 8.939   1.000 12.841  0 239 ALA A CA    1 ? 
ATOM   1904 C  C     . ALA A 1 239 ? 14.725  -17.510 8.301   1.000 13.527  0 239 ALA A C     1 ? 
ATOM   1905 O  O     . ALA A 1 239 ? 14.598  -17.204 7.097   1.000 13.097  0 239 ALA A O     1 ? 
ATOM   1906 C  CB    . ALA A 1 239 ? 12.705  -17.683 9.787   1.000 13.530  0 239 ALA A CB    1 ? 
ATOM   1907 N  N     . LEU A 1 240 ? 15.750  -17.153 9.076   1.000 15.962  0 240 LEU A N     1 ? 
ATOM   1908 C  CA    . LEU A 1 240 ? 16.795  -16.216 8.630   1.000 18.018  0 240 LEU A CA    1 ? 
ATOM   1909 C  C     . LEU A 1 240 ? 17.695  -16.889 7.591   1.000 16.273  0 240 LEU A C     1 ? 
ATOM   1910 O  O     . LEU A 1 240 ? 17.956  -16.217 6.590   1.000 15.249  0 240 LEU A O     1 ? 
ATOM   1911 C  CB    . LEU A 1 240 ? 17.578  -15.664 9.829   1.000 20.700  0 240 LEU A CB    1 ? 
ATOM   1912 C  CG    . LEU A 1 240 ? 17.956  -14.186 9.669   1.000 25.215  0 240 LEU A CG    1 ? 
ATOM   1913 C  CD1   . LEU A 1 240 ? 16.723  -13.286 9.739   1.000 25.451  0 240 LEU A CD1   1 ? 
ATOM   1914 C  CD2   . LEU A 1 240 ? 18.989  -13.770 10.711  1.000 26.578  0 240 LEU A CD2   1 ? 
ATOM   1915 N  N     . GLU A 1 241 ? 18.053  -18.165 7.765   1.000 16.856  0 241 GLU A N     1 ? 
ATOM   1916 C  CA    . GLU A 1 241 ? 18.828  -18.964 6.756   1.000 18.720  0 241 GLU A CA    1 ? 
ATOM   1917 C  C     . GLU A 1 241 ? 18.072  -19.036 5.418   1.000 19.565  0 241 GLU A C     1 ? 
ATOM   1918 O  O     . GLU A 1 241 ? 18.670  -18.719 4.340   1.000 17.559  0 241 GLU A O     1 ? 
ATOM   1919 C  CB    . GLU A 1 241 ? 19.143  -20.361 7.289   1.000 20.267  0 241 GLU A CB    1 ? 
ATOM   1920 C  CG    . GLU A 1 241 ? 19.980  -21.211 6.354   1.000 19.580  0 241 GLU A CG    1 ? 
ATOM   1921 C  CD    . GLU A 1 241 ? 20.072  -22.672 6.770   1.000 20.757  0 241 GLU A CD    1 ? 
ATOM   1922 O  OE1   . GLU A 1 241 ? 20.034  -22.962 7.993   1.000 18.278  0 241 GLU A OE1   1 ? 
ATOM   1923 O  OE2   . GLU A 1 241 ? 20.197  -23.522 5.867   1.000 21.790  0 241 GLU A OE2   1 ? 
ATOM   1924 N  N     . GLN A 1 242 ? 16.793  -19.399 5.423   1.000 20.212  0 242 GLN A N     1 ? 
ATOM   1925 C  CA    . GLN A 1 242 ? 16.036  -19.435 4.138   1.000 18.785  0 242 GLN A CA    1 ? 
ATOM   1926 C  C     . GLN A 1 242 ? 15.998  -18.027 3.519   1.000 17.076  0 242 GLN A C     1 ? 
ATOM   1927 O  O     . GLN A 1 242 ? 16.244  -17.885 2.292   1.000 15.609  0 242 GLN A O     1 ? 
ATOM   1928 C  CB    . GLN A 1 242 ? 14.607  -19.898 4.348   1.000 22.904  0 242 GLN A CB    1 ? 
ATOM   1929 C  CG    . GLN A 1 242 ? 14.480  -21.257 4.999   1.000 27.627  0 242 GLN A CG    1 ? 
ATOM   1930 C  CD    . GLN A 1 242 ? 13.019  -21.638 5.119   1.000 32.382  0 242 GLN A CD    1 ? 
ATOM   1931 O  OE1   . GLN A 1 242 ? 12.218  -21.396 4.206   1.000 36.077  0 242 GLN A OE1   1 ? 
ATOM   1932 N  NE2   . GLN A 1 242 ? 12.656  -22.263 6.235   1.000 32.503  0 242 GLN A NE2   1 ? 
ATOM   1933 N  N     . PHE A 1 243 ? 15.653  -17.003 4.309   1.000 15.087  0 243 PHE A N     1 ? 
ATOM   1934 C  CA    . PHE A 1 243 ? 15.521  -15.619 3.806   1.000 14.841  0 243 PHE A CA    1 ? 
ATOM   1935 C  C     . PHE A 1 243 ? 16.855  -15.131 3.218   1.000 14.875  0 243 PHE A C     1 ? 
ATOM   1936 O  O     . PHE A 1 243 ? 16.844  -14.584 2.056   1.000 13.096  0 243 PHE A O     1 ? 
ATOM   1937 C  CB    . PHE A 1 243 ? 15.023  -14.704 4.919   1.000 16.178  0 243 PHE A CB    1 ? 
ATOM   1938 C  CG    . PHE A 1 243 ? 14.875  -13.260 4.537   1.000 16.057  0 243 PHE A CG    1 ? 
ATOM   1939 C  CD1   . PHE A 1 243 ? 14.366  -12.903 3.309   1.000 15.922  0 243 PHE A CD1   1 ? 
ATOM   1940 C  CD2   . PHE A 1 243 ? 15.095  -12.257 5.475   1.000 17.674  0 243 PHE A CD2   1 ? 
ATOM   1941 C  CE1   . PHE A 1 243 ? 14.205  -11.571 2.982   1.000 17.167  0 243 PHE A CE1   1 ? 
ATOM   1942 C  CE2   . PHE A 1 243 ? 14.897  -10.926 5.155   1.000 16.814  0 243 PHE A CE2   1 ? 
ATOM   1943 C  CZ    . PHE A 1 243 ? 14.489  -10.584 3.900   1.000 16.935  0 243 PHE A CZ    1 ? 
ATOM   1944 N  N     . VAL A 1 244 ? 17.969  -15.268 3.952   1.000 14.400  0 244 VAL A N     1 ? 
ATOM   1945 C  CA    . VAL A 1 244 ? 19.298  -14.781 3.454   1.000 14.977  0 244 VAL A CA    1 ? 
ATOM   1946 C  C     . VAL A 1 244 ? 19.664  -15.539 2.159   1.000 15.719  0 244 VAL A C     1 ? 
ATOM   1947 O  O     . VAL A 1 244 ? 19.978  -14.857 1.146   1.000 14.718  0 244 VAL A O     1 ? 
ATOM   1948 C  CB    . VAL A 1 244 ? 20.372  -14.839 4.551   1.000 15.369  0 244 VAL A CB    1 ? 
ATOM   1949 C  CG1   . VAL A 1 244 ? 21.775  -14.610 4.020   1.000 15.076  0 244 VAL A CG1   1 ? 
ATOM   1950 C  CG2   . VAL A 1 244 ? 20.061  -13.826 5.655   1.000 15.294  0 244 VAL A CG2   1 ? 
ATOM   1951 N  N     . GLN A 1 245 ? 19.465  -16.856 2.106   1.000 16.889  0 245 GLN A N     1 ? 
ATOM   1952 C  CA    . GLN A 1 245 ? 19.773  -17.679 0.891   1.000 16.843  0 245 GLN A CA    1 ? 
ATOM   1953 C  C     . GLN A 1 245 ? 18.943  -17.190 -0.321  1.000 17.579  0 245 GLN A C     1 ? 
ATOM   1954 O  O     . GLN A 1 245 ? 19.538  -16.958 -1.401  1.000 15.014  0 245 GLN A O     1 ? 
ATOM   1955 C  CB    . GLN A 1 245 ? 19.558  -19.160 1.185   1.000 17.744  0 245 GLN A CB    1 ? 
ATOM   1956 C  CG    . GLN A 1 245 ? 19.884  -20.037 -0.021  1.000 21.019  0 245 GLN A CG    1 ? 
ATOM   1957 C  CD    . GLN A 1 245 ? 21.371  -20.060 -0.260  1.000 21.451  0 245 GLN A CD    1 ? 
ATOM   1958 O  OE1   . GLN A 1 245 ? 22.104  -20.734 0.455   1.000 26.236  0 245 GLN A OE1   1 ? 
ATOM   1959 N  NE2   . GLN A 1 245 ? 21.837  -19.334 -1.266  1.000 23.863  0 245 GLN A NE2   1 ? 
ATOM   1960 N  N     . THR A 1 246 ? 17.627  -16.997 -0.153  1.000 16.611  0 246 THR A N     1 ? 
ATOM   1961 C  CA    . THR A 1 246 ? 16.746  -16.374 -1.168  1.000 17.255  0 246 THR A CA    1 ? 
ATOM   1962 C  C     . THR A 1 246 ? 17.309  -15.031 -1.649  1.000 16.970  0 246 THR A C     1 ? 
ATOM   1963 O  O     . THR A 1 246 ? 17.399  -14.857 -2.873  1.000 17.295  0 246 THR A O     1 ? 
ATOM   1964 C  CB    . THR A 1 246 ? 15.301  -16.295 -0.682  1.000 18.315  0 246 THR A CB    1 ? 
ATOM   1965 O  OG1   . THR A 1 246 ? 14.964  -17.622 -0.264  1.000 19.003  0 246 THR A OG1   1 ? 
ATOM   1966 C  CG2   . THR A 1 246 ? 14.351  -15.830 -1.763  1.000 18.831  0 246 THR A CG2   1 ? 
ATOM   1967 N  N     . MET A 1 247 ? 17.661  -14.104 -0.762  1.000 14.653  0 247 MET A N     1 ? 
ATOM   1968 C  CA    . MET A 1 247 ? 18.245  -12.800 -1.177  1.000 16.249  0 247 MET A CA    1 ? 
ATOM   1969 C  C     . MET A 1 247 ? 19.482  -13.057 -2.039  1.000 14.824  0 247 MET A C     1 ? 
ATOM   1970 O  O     . MET A 1 247 ? 19.611  -12.490 -3.144  1.000 13.886  0 247 MET A O     1 ? 
ATOM   1971 C  CB    . MET A 1 247 ? 18.630  -11.942 0.039   1.000 17.548  0 247 MET A CB    1 ? 
ATOM   1972 C  CG    . MET A 1 247 ? 17.435  -11.329 0.713   1.000 17.950  0 247 MET A CG    1 ? 
ATOM   1973 S  SD    . MET A 1 247 ? 17.859  -10.192 2.027   1.000 19.470  0 247 MET A SD    1 ? 
ATOM   1974 C  CE    . MET A 1 247 ? 18.495  -8.827  1.084   1.000 21.107  0 247 MET A CE    1 ? 
ATOM   1975 N  N     . LEU A 1 248 ? 20.382  -13.876 -1.541  1.000 14.717  0 248 LEU A N     1 ? 
ATOM   1976 C  CA    . LEU A 1 248 ? 21.646  -14.189 -2.248  1.000 15.779  0 248 LEU A CA    1 ? 
ATOM   1977 C  C     . LEU A 1 248 ? 21.289  -14.759 -3.616  1.000 17.599  0 248 LEU A C     1 ? 
ATOM   1978 O  O     . LEU A 1 248 ? 21.960  -14.354 -4.607  1.000 18.653  0 248 LEU A O     1 ? 
ATOM   1979 C  CB    . LEU A 1 248 ? 22.459  -15.196 -1.423  1.000 15.933  0 248 LEU A CB    1 ? 
ATOM   1980 C  CG    . LEU A 1 248 ? 23.252  -14.636 -0.237  1.000 16.332  0 248 LEU A CG    1 ? 
ATOM   1981 C  CD1   . LEU A 1 248 ? 23.722  -15.758 0.670   1.000 18.819  0 248 LEU A CD1   1 ? 
ATOM   1982 C  CD2   . LEU A 1 248 ? 24.455  -13.838 -0.706  1.000 17.321  0 248 LEU A CD2   1 ? 
ATOM   1983 N  N     . ASP A 1 249 ? 20.256  -15.622 -3.682  1.000 16.470  0 249 ASP A N     1 ? 
ATOM   1984 C  CA    . ASP A 1 249 ? 19.881  -16.288 -4.944  1.000 19.179  0 249 ASP A CA    1 ? 
ATOM   1985 C  C     . ASP A 1 249 ? 19.395  -15.229 -5.915  1.000 19.472  0 249 ASP A C     1 ? 
ATOM   1986 O  O     . ASP A 1 249 ? 19.407  -15.516 -7.093  1.000 20.103  0 249 ASP A O     1 ? 
ATOM   1987 C  CB    . ASP A 1 249 ? 18.765  -17.323 -4.809  1.000 21.173  0 249 ASP A CB    1 ? 
ATOM   1988 C  CG    . ASP A 1 249 ? 19.154  -18.592 -4.085  1.000 20.643  0 249 ASP A CG    1 ? 
ATOM   1989 O  OD1   . ASP A 1 249 ? 20.325  -18.977 -4.141  1.000 19.689  0 249 ASP A OD1   1 ? 
ATOM   1990 O  OD2   . ASP A 1 249 ? 18.275  -19.133 -3.434  1.000 25.944  0 249 ASP A OD2   1 ? 
ATOM   1991 N  N     . ASN A 1 250 ? 18.924  -14.081 -5.429  1.000 17.131  0 250 ASN A N     1 ? 
ATOM   1992 C  CA    . ASN A 1 250 ? 18.309  -13.084 -6.335  1.000 18.391  0 250 ASN A CA    1 ? 
ATOM   1993 C  C     . ASN A 1 250 ? 19.344  -12.078 -6.847  1.000 17.867  0 250 ASN A C     1 ? 
ATOM   1994 O  O     . ASN A 1 250 ? 18.963  -11.297 -7.707  1.000 20.756  0 250 ASN A O     1 ? 
ATOM   1995 C  CB    . ASN A 1 250 ? 17.084  -12.446 -5.692  1.000 18.696  0 250 ASN A CB    1 ? 
ATOM   1996 C  CG    . ASN A 1 250 ? 15.855  -13.311 -5.881  1.000 20.602  0 250 ASN A CG    1 ? 
ATOM   1997 O  OD1   . ASN A 1 250 ? 15.191  -13.218 -6.920  1.000 20.398  0 250 ASN A OD1   1 ? 
ATOM   1998 N  ND2   . ASN A 1 250 ? 15.554  -14.161 -4.900  1.000 21.134  0 250 ASN A ND2   1 ? 
ATOM   1999 N  N     . PHE A 1 251 ? 20.590  -12.086 -6.362  1.000 17.018  0 251 PHE A N     1 ? 
ATOM   2000 C  CA    . PHE A 1 251 ? 21.683  -11.292 -6.991  1.000 17.232  0 251 PHE A CA    1 ? 
ATOM   2001 C  C     . PHE A 1 251 ? 21.917  -11.820 -8.408  1.000 17.495  0 251 PHE A C     1 ? 
ATOM   2002 O  O     . PHE A 1 251 ? 21.760  -13.035 -8.638  1.000 20.871  0 251 PHE A O     1 ? 
ATOM   2003 C  CB    . PHE A 1 251 ? 22.991  -11.353 -6.208  1.000 15.529  0 251 PHE A CB    1 ? 
ATOM   2004 C  CG    . PHE A 1 251 ? 23.045  -10.503 -4.976  1.000 14.935  0 251 PHE A CG    1 ? 
ATOM   2005 C  CD1   . PHE A 1 251 ? 22.299  -10.843 -3.875  1.000 14.725  0 251 PHE A CD1   1 ? 
ATOM   2006 C  CD2   . PHE A 1 251 ? 23.907  -9.412  -4.892  1.000 14.534  0 251 PHE A CD2   1 ? 
ATOM   2007 C  CE1   . PHE A 1 251 ? 22.381  -10.098 -2.716  1.000 14.738  0 251 PHE A CE1   1 ? 
ATOM   2008 C  CE2   . PHE A 1 251 ? 24.003  -8.679  -3.729  1.000 13.791  0 251 PHE A CE2   1 ? 
ATOM   2009 C  CZ    . PHE A 1 251 ? 23.244  -9.028  -2.639  1.000 14.330  0 251 PHE A CZ    1 ? 
ATOM   2010 N  N     . HIS A 1 252 ? 22.227  -10.922 -9.339  1.000 20.279  0 252 HIS A N     1 ? 
ATOM   2011 C  CA    . HIS A 1 252 ? 22.565  -11.246 -10.752 1.000 22.431  0 252 HIS A CA    1 ? 
ATOM   2012 C  C     . HIS A 1 252 ? 23.867  -10.530 -11.129 1.000 21.306  0 252 HIS A C     1 ? 
ATOM   2013 O  O     . HIS A 1 252 ? 23.969  -9.329  -10.846 1.000 19.796  0 252 HIS A O     1 ? 
ATOM   2014 C  CB    . HIS A 1 252 ? 21.388  -10.896 -11.670 1.000 26.136  0 252 HIS A CB    1 ? 
ATOM   2015 C  CG    . HIS A 1 252 ? 20.168  -11.690 -11.350 1.000 30.211  0 252 HIS A CG    1 ? 
ATOM   2016 N  ND1   . HIS A 1 252 ? 19.031  -11.109 -10.837 1.000 33.952  0 252 HIS A ND1   1 ? 
ATOM   2017 C  CD2   . HIS A 1 252 ? 19.927  -13.025 -11.417 1.000 33.410  0 252 HIS A CD2   1 ? 
ATOM   2018 C  CE1   . HIS A 1 252 ? 18.118  -12.049 -10.628 1.000 36.719  0 252 HIS A CE1   1 ? 
ATOM   2019 N  NE2   . HIS A 1 252 ? 18.653  -13.237 -10.964 1.000 36.835  0 252 HIS A NE2   1 ? 
ATOM   2020 N  N     . ASP A 1 253 ? 24.815  -11.262 -11.708 1.000 22.919  0 253 ASP A N     1 ? 
ATOM   2021 C  CA    . ASP A 1 253 ? 26.104  -10.704 -12.177 1.000 22.306  0 253 ASP A CA    1 ? 
ATOM   2022 C  C     . ASP A 1 253 ? 25.825  -9.811  -13.370 1.000 22.072  0 253 ASP A C     1 ? 
ATOM   2023 O  O     . ASP A 1 253 ? 25.365  -10.326 -14.376 1.000 22.239  0 253 ASP A O     1 ? 
ATOM   2024 C  CB    . ASP A 1 253 ? 27.097  -11.789 -12.524 1.000 23.870  0 253 ASP A CB    1 ? 
ATOM   2025 C  CG    . ASP A 1 253 ? 27.592  -12.527 -11.297 1.000 26.213  0 253 ASP A CG    1 ? 
ATOM   2026 O  OD1   . ASP A 1 253 ? 27.596  -11.931 -10.194 1.000 24.871  0 253 ASP A OD1   1 ? 
ATOM   2027 O  OD2   . ASP A 1 253 ? 27.975  -13.665 -11.462 1.000 28.372  0 253 ASP A OD2   1 ? 
ATOM   2028 N  N     . THR A 1 254 ? 26.120  -8.528  -13.220 1.000 20.893  0 254 THR A N     1 ? 
ATOM   2029 C  CA    . THR A 1 254 ? 25.718  -7.449  -14.141 1.000 19.724  0 254 THR A CA    1 ? 
ATOM   2030 C  C     . THR A 1 254 ? 26.985  -6.804  -14.688 1.000 20.546  0 254 THR A C     1 ? 
ATOM   2031 O  O     . THR A 1 254 ? 27.689  -6.140  -13.887 1.000 17.634  0 254 THR A O     1 ? 
ATOM   2032 C  CB    . THR A 1 254 ? 24.818  -6.454  -13.412 1.000 20.771  0 254 THR A CB    1 ? 
ATOM   2033 O  OG1   . THR A 1 254 ? 23.868  -7.243  -12.688 1.000 21.376  0 254 THR A OG1   1 ? 
ATOM   2034 C  CG2   . THR A 1 254 ? 24.114  -5.487  -14.331 1.000 21.204  0 254 THR A CG2   1 ? 
ATOM   2035 N  N     . TRP A 1 255 ? 27.222  -6.961  -16.000 1.000 18.532  0 255 TRP A N     1 ? 
ATOM   2036 C  CA    . TRP A 1 255 ? 28.377  -6.356  -16.690 1.000 18.585  0 255 TRP A CA    1 ? 
ATOM   2037 C  C     . TRP A 1 255 ? 28.330  -4.849  -16.535 1.000 18.357  0 255 TRP A C     1 ? 
ATOM   2038 O  O     . TRP A 1 255 ? 27.252  -4.272  -16.674 1.000 17.193  0 255 TRP A O     1 ? 
ATOM   2039 C  CB    . TRP A 1 255 ? 28.383  -6.779  -18.147 1.000 19.311  0 255 TRP A CB    1 ? 
ATOM   2040 C  CG    . TRP A 1 255 ? 29.555  -6.268  -18.914 1.000 19.206  0 255 TRP A CG    1 ? 
ATOM   2041 C  CD1   . TRP A 1 255 ? 29.544  -5.275  -19.849 1.000 17.792  0 255 TRP A CD1   1 ? 
ATOM   2042 C  CD2   . TRP A 1 255 ? 30.894  -6.777  -18.864 1.000 18.277  0 255 TRP A CD2   1 ? 
ATOM   2043 N  NE1   . TRP A 1 255 ? 30.793  -5.136  -20.386 1.000 19.067  0 255 TRP A NE1   1 ? 
ATOM   2044 C  CE2   . TRP A 1 255 ? 31.638  -6.054  -19.817 1.000 18.763  0 255 TRP A CE2   1 ? 
ATOM   2045 C  CE3   . TRP A 1 255 ? 31.533  -7.767  -18.116 1.000 18.762  0 255 TRP A CE3   1 ? 
ATOM   2046 C  CZ2   . TRP A 1 255 ? 33.004  -6.278  -20.010 1.000 20.583  0 255 TRP A CZ2   1 ? 
ATOM   2047 C  CZ3   . TRP A 1 255 ? 32.863  -8.018  -18.337 1.000 18.513  0 255 TRP A CZ3   1 ? 
ATOM   2048 C  CH2   . TRP A 1 255 ? 33.595  -7.275  -19.262 1.000 20.254  0 255 TRP A CH2   1 ? 
ATOM   2049 N  N     . ASP A 1 256 ? 29.459  -4.239  -16.192 1.000 19.716  0 256 ASP A N     1 ? 
ATOM   2050 C  CA    . ASP A 1 256 ? 29.619  -2.768  -16.229 1.000 21.443  0 256 ASP A CA    1 ? 
ATOM   2051 C  C     . ASP A 1 256 ? 30.544  -2.439  -17.402 1.000 20.417  0 256 ASP A C     1 ? 
ATOM   2052 O  O     . ASP A 1 256 ? 31.692  -2.820  -17.310 1.000 18.080  0 256 ASP A O     1 ? 
ATOM   2053 C  CB    . ASP A 1 256 ? 30.205  -2.238  -14.921 1.000 22.715  0 256 ASP A CB    1 ? 
ATOM   2054 C  CG    . ASP A 1 256 ? 30.186  -0.722  -14.859 1.000 23.928  0 256 ASP A CG    1 ? 
ATOM   2055 O  OD1   . ASP A 1 256 ? 31.251  -0.092  -15.062 1.000 25.008  0 256 ASP A OD1   1 ? 
ATOM   2056 O  OD2   . ASP A 1 256 ? 29.099  -0.187  -14.696 1.000 25.007  0 256 ASP A OD2   1 ? 
ATOM   2057 N  N     . SER A 1 257 ? 30.042  -1.792  -18.459 1.000 20.622  0 257 SER A N     1 ? 
ATOM   2058 C  CA    . SER A 1 257 ? 30.842  -1.435  -19.667 1.000 22.595  0 257 SER A CA    1 ? 
ATOM   2059 C  C     . SER A 1 257 ? 31.965  -0.448  -19.277 1.000 23.902  0 257 SER A C     1 ? 
ATOM   2060 O  O     . SER A 1 257 ? 33.069  -0.596  -19.805 1.000 23.264  0 257 SER A O     1 ? 
ATOM   2061 C  CB    . SER A 1 257 ? 29.978  -0.852  -20.770 1.000 20.242  0 257 SER A CB    1 ? 
ATOM   2062 O  OG    . SER A 1 257 ? 29.187  -1.847  -21.374 1.000 20.285  0 257 SER A OG    1 ? 
ATOM   2063 N  N     . LYS A 1 258 ? 31.711  0.511   -18.378 1.000 26.745  0 258 LYS A N     1 ? 
ATOM   2064 C  CA    . LYS A 1 258 ? 32.749  1.489   -17.930 1.000 31.342  0 258 LYS A CA    1 ? 
ATOM   2065 C  C     . LYS A 1 258 ? 33.931  0.721   -17.298 1.000 29.244  0 258 LYS A C     1 ? 
ATOM   2066 O  O     . LYS A 1 258 ? 35.054  0.934   -17.750 1.000 26.765  0 258 LYS A O     1 ? 
ATOM   2067 C  CB    . LYS A 1 258 ? 32.132  2.548   -17.009 1.000 35.625  0 258 LYS A CB    1 ? 
ATOM   2068 C  CG    . LYS A 1 258 ? 33.058  3.678   -16.574 1.000 42.311  0 258 LYS A CG    1 ? 
ATOM   2069 C  CD    . LYS A 1 258 ? 33.664  4.477   -17.718 1.000 50.110  0 258 LYS A CD    1 ? 
ATOM   2070 C  CE    . LYS A 1 258 ? 32.640  5.213   -18.564 1.000 54.807  0 258 LYS A CE    1 ? 
ATOM   2071 N  NZ    . LYS A 1 258 ? 33.294  6.189   -19.473 1.000 57.367  0 258 LYS A NZ    1 ? 
ATOM   2072 N  N     . ASP A 1 259 ? 33.698  -0.184  -16.342 1.000 25.193  0 259 ASP A N     1 ? 
ATOM   2073 C  CA    . ASP A 1 259 ? 34.795  -0.855  -15.598 1.000 25.979  0 259 ASP A CA    1 ? 
ATOM   2074 C  C     . ASP A 1 259 ? 35.289  -2.108  -16.327 1.000 24.399  0 259 ASP A C     1 ? 
ATOM   2075 O  O     . ASP A 1 259 ? 36.279  -2.670  -15.851 1.000 22.602  0 259 ASP A O     1 ? 
ATOM   2076 C  CB    . ASP A 1 259 ? 34.390  -1.205  -14.167 1.000 26.243  0 259 ASP A CB    1 ? 
ATOM   2077 C  CG    . ASP A 1 259 ? 34.050  0.005   -13.331 1.000 28.392  0 259 ASP A CG    1 ? 
ATOM   2078 O  OD1   . ASP A 1 259 ? 34.171  1.125   -13.859 1.000 31.852  0 259 ASP A OD1   1 ? 
ATOM   2079 O  OD2   . ASP A 1 259 ? 33.618  -0.187  -12.173 1.000 31.582  0 259 ASP A OD2   1 ? 
ATOM   2080 N  N     . GLN A 1 260 ? 34.601  -2.575  -17.378 1.000 21.418  0 260 GLN A N     1 ? 
ATOM   2081 C  CA    . GLN A 1 260 ? 34.937  -3.824  -18.109 1.000 22.074  0 260 GLN A CA    1 ? 
ATOM   2082 C  C     . GLN A 1 260 ? 35.002  -4.983  -17.105 1.000 22.813  0 260 GLN A C     1 ? 
ATOM   2083 O  O     . GLN A 1 260 ? 35.911  -5.826  -17.181 1.000 20.716  0 260 GLN A O     1 ? 
ATOM   2084 C  CB    . GLN A 1 260 ? 36.208  -3.608  -18.934 1.000 22.536  0 260 GLN A CB    1 ? 
ATOM   2085 C  CG    . GLN A 1 260 ? 35.983  -2.682  -20.115 1.000 22.241  0 260 GLN A CG    1 ? 
ATOM   2086 C  CD    . GLN A 1 260 ? 35.200  -3.337  -21.239 1.000 22.530  0 260 GLN A CD    1 ? 
ATOM   2087 O  OE1   . GLN A 1 260 ? 35.610  -4.336  -21.828 1.000 22.772  0 260 GLN A OE1   1 ? 
ATOM   2088 N  NE2   . GLN A 1 260 ? 34.053  -2.769  -21.554 1.000 22.508  0 260 GLN A NE2   1 ? 
ATOM   2089 N  N     . ARG A 1 261 ? 33.989  -5.081  -16.232 1.000 22.926  0 261 ARG A N     1 ? 
ATOM   2090 C  CA    . ARG A 1 261 ? 33.817  -6.282  -15.393 1.000 20.343  0 261 ARG A CA    1 ? 
ATOM   2091 C  C     . ARG A 1 261 ? 32.368  -6.428  -14.936 1.000 18.947  0 261 ARG A C     1 ? 
ATOM   2092 O  O     . ARG A 1 261 ? 31.582  -5.544  -15.179 1.000 21.177  0 261 ARG A O     1 ? 
ATOM   2093 C  CB    . ARG A 1 261 ? 34.765  -6.177  -14.201 1.000 22.287  0 261 ARG A CB    1 ? 
ATOM   2094 C  CG    . ARG A 1 261 ? 34.559  -4.931  -13.351 1.000 22.173  0 261 ARG A CG    1 ? 
ATOM   2095 C  CD    . ARG A 1 261 ? 35.084  -5.139  -11.940 1.000 23.337  0 261 ARG A CD    1 ? 
ATOM   2096 N  NE    . ARG A 1 261 ? 34.257  -6.074  -11.162 1.000 23.065  0 261 ARG A NE    1 ? 
ATOM   2097 C  CZ    . ARG A 1 261 ? 34.502  -6.419  -9.899  1.000 23.542  0 261 ARG A CZ    1 ? 
ATOM   2098 N  NH1   . ARG A 1 261 ? 35.530  -5.882  -9.258  1.000 23.543  0 261 ARG A NH1   1 ? 
ATOM   2099 N  NH2   . ARG A 1 261 ? 33.726  -7.297  -9.284  1.000 20.899  0 261 ARG A NH2   1 ? 
ATOM   2100 N  N     . SER A 1 262 ? 32.079  -7.504  -14.213 1.000 18.418  0 262 SER A N     1 ? 
ATOM   2101 C  CA    . SER A 1 262 ? 30.749  -7.784  -13.617 1.000 21.405  0 262 SER A CA    1 ? 
ATOM   2102 C  C     . SER A 1 262 ? 30.761  -7.451  -12.126 1.000 19.641  0 262 SER A C     1 ? 
ATOM   2103 O  O     . SER A 1 262 ? 31.822  -7.585  -11.479 1.000 17.980  0 262 SER A O     1 ? 
ATOM   2104 C  CB    . SER A 1 262 ? 30.328  -9.198  -13.875 1.000 20.520  0 262 SER A CB    1 ? 
ATOM   2105 O  OG    . SER A 1 262 ? 30.246  -9.382  -15.273 1.000 24.666  0 262 SER A OG    1 ? 
ATOM   2106 N  N     . TYR A 1 263 ? 29.635  -6.940  -11.652 1.000 18.124  0 263 TYR A N     1 ? 
ATOM   2107 C  CA    . TYR A 1 263 ? 29.324  -6.815  -10.216 1.000 18.989  0 263 TYR A CA    1 ? 
ATOM   2108 C  C     . TYR A 1 263 ? 28.032  -7.578  -9.965  1.000 18.408  0 263 TYR A C     1 ? 
ATOM   2109 O  O     . TYR A 1 263 ? 27.140  -7.588  -10.804 1.000 17.246  0 263 TYR A O     1 ? 
ATOM   2110 C  CB    . TYR A 1 263 ? 29.220  -5.352  -9.807  1.000 18.868  0 263 TYR A CB    1 ? 
ATOM   2111 C  CG    . TYR A 1 263 ? 30.447  -4.525  -10.072 1.000 19.409  0 263 TYR A CG    1 ? 
ATOM   2112 C  CD1   . TYR A 1 263 ? 31.510  -4.484  -9.176  1.000 19.987  0 263 TYR A CD1   1 ? 
ATOM   2113 C  CD2   . TYR A 1 263 ? 30.530  -3.744  -11.216 1.000 19.210  0 263 TYR A CD2   1 ? 
ATOM   2114 C  CE1   . TYR A 1 263 ? 32.626  -3.693  -9.415  1.000 18.006  0 263 TYR A CE1   1 ? 
ATOM   2115 C  CE2   . TYR A 1 263 ? 31.630  -2.949  -11.456 1.000 19.565  0 263 TYR A CE2   1 ? 
ATOM   2116 C  CZ    . TYR A 1 263 ? 32.682  -2.927  -10.559 1.000 19.404  0 263 TYR A CZ    1 ? 
ATOM   2117 O  OH    . TYR A 1 263 ? 33.737  -2.099  -10.818 1.000 19.657  0 263 TYR A OH    1 ? 
ATOM   2118 N  N     . PRO A 1 264 ? 27.902  -8.233  -8.800  1.000 18.455  0 264 PRO A N     1 ? 
ATOM   2119 C  CA    . PRO A 1 264 ? 26.657  -8.905  -8.441  1.000 18.880  0 264 PRO A CA    1 ? 
ATOM   2120 C  C     . PRO A 1 264 ? 25.709  -7.781  -8.051  1.000 20.165  0 264 PRO A C     1 ? 
ATOM   2121 O  O     . PRO A 1 264 ? 26.138  -6.859  -7.368  1.000 29.422  0 264 PRO A O     1 ? 
ATOM   2122 C  CB    . PRO A 1 264 ? 27.037  -9.814  -7.277  1.000 18.553  0 264 PRO A CB    1 ? 
ATOM   2123 C  CG    . PRO A 1 264 ? 28.240  -9.133  -6.641  1.000 18.925  0 264 PRO A CG    1 ? 
ATOM   2124 C  CD    . PRO A 1 264 ? 28.912  -8.316  -7.731  1.000 19.364  0 264 PRO A CD    1 ? 
ATOM   2125 N  N     . ARG A 1 265 ? 24.492  -7.816  -8.538  1.000 17.659  0 265 ARG A N     1 ? 
ATOM   2126 C  CA    . ARG A 1 265 ? 23.505  -6.766  -8.208  1.000 17.494  0 265 ARG A CA    1 ? 
ATOM   2127 C  C     . ARG A 1 265 ? 22.215  -7.429  -7.750  1.000 15.745  0 265 ARG A C     1 ? 
ATOM   2128 O  O     . ARG A 1 265 ? 21.727  -8.342  -8.461  1.000 13.739  0 265 ARG A O     1 ? 
ATOM   2129 C  CB    . ARG A 1 265 ? 23.277  -5.849  -9.405  1.000 18.389  0 265 ARG A CB    1 ? 
ATOM   2130 C  CG    . ARG A 1 265 ? 24.373  -4.810  -9.597  1.000 20.161  0 265 ARG A CG    1 ? 
ATOM   2131 C  CD    . ARG A 1 265 ? 23.775  -3.560  -10.231 1.000 20.434  0 265 ARG A CD    1 ? 
ATOM   2132 N  NE    . ARG A 1 265 ? 23.017  -2.751  -9.281  1.000 18.634  0 265 ARG A NE    1 ? 
ATOM   2133 C  CZ    . ARG A 1 265 ? 23.512  -1.755  -8.567  1.000 19.691  0 265 ARG A CZ    1 ? 
ATOM   2134 N  NH1   . ARG A 1 265 ? 24.795  -1.426  -8.675  1.000 20.145  0 265 ARG A NH1   1 ? 
ATOM   2135 N  NH2   . ARG A 1 265 ? 22.719  -1.089  -7.736  1.000 21.129  0 265 ARG A NH2   1 ? 
ATOM   2136 N  N     . LEU A 1 266 ? 21.714  -6.973  -6.611  1.000 16.136  0 266 LEU A N     1 ? 
ATOM   2137 C  CA    . LEU A 1 266 ? 20.380  -7.357  -6.078  1.000 16.780  0 266 LEU A CA    1 ? 
ATOM   2138 C  C     . LEU A 1 266 ? 19.426  -6.196  -6.330  1.000 15.460  0 266 LEU A C     1 ? 
ATOM   2139 O  O     . LEU A 1 266 ? 19.711  -5.103  -5.863  1.000 16.095  0 266 LEU A O     1 ? 
ATOM   2140 C  CB    . LEU A 1 266 ? 20.480  -7.667  -4.585  1.000 15.798  0 266 LEU A CB    1 ? 
ATOM   2141 C  CG    . LEU A 1 266 ? 19.165  -8.081  -3.927  1.000 14.738  0 266 LEU A CG    1 ? 
ATOM   2142 C  CD1   . LEU A 1 266 ? 18.622  -9.377  -4.509  1.000 15.481  0 266 LEU A CD1   1 ? 
ATOM   2143 C  CD2   . LEU A 1 266 ? 19.329  -8.199  -2.441  1.000 14.517  0 266 LEU A CD2   1 ? 
ATOM   2144 N  N     . THR A 1 267 ? 18.350  -6.448  -7.080  1.000 17.016  0 267 THR A N     1 ? 
ATOM   2145 C  CA    . THR A 1 267 ? 17.274  -5.471  -7.382  1.000 18.272  0 267 THR A CA    1 ? 
ATOM   2146 C  C     . THR A 1 267 ? 16.085  -5.778  -6.472  1.000 18.726  0 267 THR A C     1 ? 
ATOM   2147 O  O     . THR A 1 267 ? 15.725  -6.926  -6.373  1.000 19.152  0 267 THR A O     1 ? 
ATOM   2148 C  CB    . THR A 1 267 ? 16.874  -5.579  -8.856  1.000 20.120  0 267 THR A CB    1 ? 
ATOM   2149 O  OG1   . THR A 1 267 ? 18.047  -5.283  -9.601  1.000 19.164  0 267 THR A OG1   1 ? 
ATOM   2150 C  CG2   . THR A 1 267 ? 15.770  -4.630  -9.257  1.000 20.973  0 267 THR A CG2   1 ? 
ATOM   2151 N  N     . VAL A 1 268 ? 15.554  -4.792  -5.769  1.000 20.216  0 268 VAL A N     1 ? 
ATOM   2152 C  CA    . VAL A 1 268 ? 14.385  -5.003  -4.885  1.000 21.047  0 268 VAL A CA    1 ? 
ATOM   2153 C  C     . VAL A 1 268 ? 13.450  -3.841  -5.150  1.000 20.466  0 268 VAL A C     1 ? 
ATOM   2154 O  O     . VAL A 1 268 ? 13.778  -2.726  -4.739  1.000 20.700  0 268 VAL A O     1 ? 
ATOM   2155 C  CB    . VAL A 1 268 ? 14.790  -5.082  -3.412  1.000 22.086  0 268 VAL A CB    1 ? 
ATOM   2156 C  CG1   . VAL A 1 268 ? 13.584  -5.341  -2.530  1.000 24.267  0 268 VAL A CG1   1 ? 
ATOM   2157 C  CG2   . VAL A 1 268 ? 15.839  -6.146  -3.195  1.000 24.339  0 268 VAL A CG2   1 ? 
ATOM   2158 N  N     . GLU A 1 269 ? 12.413  -4.096  -5.929  1.000 19.501  0 269 GLU A N     1 ? 
ATOM   2159 C  CA    . GLU A 1 269 ? 11.365  -3.115  -6.239  1.000 22.322  0 269 GLU A CA    1 ? 
ATOM   2160 C  C     . GLU A 1 269 ? 10.530  -2.872  -4.981  1.000 21.278  0 269 GLU A C     1 ? 
ATOM   2161 O  O     . GLU A 1 269 ? 10.080  -3.865  -4.369  1.000 18.898  0 269 GLU A O     1 ? 
ATOM   2162 C  CB    . GLU A 1 269 ? 10.489  -3.621  -7.383  1.000 26.424  0 269 GLU A CB    1 ? 
ATOM   2163 C  CG    . GLU A 1 269 ? 11.139  -3.450  -8.744  1.000 30.119  0 269 GLU A CG    1 ? 
ATOM   2164 C  CD    . GLU A 1 269 ? 10.158  -3.536  -9.894  1.000 34.330  0 269 GLU A CD    1 ? 
ATOM   2165 O  OE1   . GLU A 1 269 ? 8.917   -3.574  -9.637  1.000 39.748  0 269 GLU A OE1   1 ? 
ATOM   2166 O  OE2   . GLU A 1 269 ? 10.627  -3.570  -11.040 1.000 40.311  0 269 GLU A OE2   1 ? 
ATOM   2167 N  N     . LEU A 1 270 ? 10.239  -1.606  -4.685  1.000 21.105  0 270 LEU A N     1 ? 
ATOM   2168 C  CA    . LEU A 1 270 ? 9.134   -1.252  -3.770  1.000 22.545  0 270 LEU A CA    1 ? 
ATOM   2169 C  C     . LEU A 1 270 ? 7.892   -1.909  -4.357  1.000 21.356  0 270 LEU A C     1 ? 
ATOM   2170 O  O     . LEU A 1 270 ? 7.752   -1.889  -5.572  1.000 21.908  0 270 LEU A O     1 ? 
ATOM   2171 C  CB    . LEU A 1 270 ? 9.006   0.273   -3.726  1.000 26.252  0 270 LEU A CB    1 ? 
ATOM   2172 C  CG    . LEU A 1 270 ? 8.478   0.871   -2.435  1.000 27.395  0 270 LEU A CG    1 ? 
ATOM   2173 C  CD1   . LEU A 1 270 ? 9.452   0.629   -1.275  1.000 28.822  0 270 LEU A CD1   1 ? 
ATOM   2174 C  CD2   . LEU A 1 270 ? 8.228   2.364   -2.624  1.000 29.322  0 270 LEU A CD2   1 ? 
ATOM   2175 N  N     . PRO A 1 271 ? 7.010   -2.573  -3.559  1.000 19.449  0 271 PRO A N     1 ? 
ATOM   2176 C  CA    . PRO A 1 271 ? 5.773   -3.165  -4.102  1.000 18.598  0 271 PRO A CA    1 ? 
ATOM   2177 C  C     . PRO A 1 271 ? 4.553   -2.236  -4.246  1.000 20.310  0 271 PRO A C     1 ? 
ATOM   2178 O  O     . PRO A 1 271 ? 3.484   -2.735  -4.508  1.000 21.186  0 271 PRO A O     1 ? 
ATOM   2179 C  CB    . PRO A 1 271 ? 5.479   -4.236  -3.053  1.000 16.858  0 271 PRO A CB    1 ? 
ATOM   2180 C  CG    . PRO A 1 271 ? 5.911   -3.584  -1.761  1.000 17.146  0 271 PRO A CG    1 ? 
ATOM   2181 C  CD    . PRO A 1 271 ? 7.208   -2.884  -2.131  1.000 18.789  0 271 PRO A CD    1 ? 
ATOM   2182 N  N     . VAL A 1 272 ? 4.738   -0.934  -4.019  1.000 21.795  0 272 VAL A N     1 ? 
ATOM   2183 C  CA    . VAL A 1 272 ? 3.754   0.161   -4.269  1.000 20.655  0 272 VAL A CA    1 ? 
ATOM   2184 C  C     . VAL A 1 272 ? 4.500   1.232   -5.077  1.000 23.310  0 272 VAL A C     1 ? 
ATOM   2185 O  O     . VAL A 1 272 ? 5.771   1.103   -5.261  1.000 21.047  0 272 VAL A O     1 ? 
ATOM   2186 C  CB    . VAL A 1 272 ? 3.173   0.737   -2.953  1.000 19.780  0 272 VAL A CB    1 ? 
ATOM   2187 C  CG1   . VAL A 1 272 ? 2.472   -0.294  -2.108  1.000 19.807  0 272 VAL A CG1   1 ? 
ATOM   2188 C  CG2   . VAL A 1 272 ? 4.223   1.413   -2.109  1.000 20.214  0 272 VAL A CG2   1 ? 
ATOM   2189 N  N     . GLN A 1 273 ? 3.778   2.261   -5.526  1.000 22.468  0 273 GLN A N     1 ? 
ATOM   2190 C  CA    . GLN A 1 273 ? 4.333   3.419   -6.287  1.000 23.502  0 273 GLN A CA    1 ? 
ATOM   2191 C  C     . GLN A 1 273 ? 5.460   4.074   -5.487  1.000 20.849  0 273 GLN A C     1 ? 
ATOM   2192 O  O     . GLN A 1 273 ? 5.341   4.198   -4.278  1.000 22.537  0 273 GLN A O     1 ? 
ATOM   2193 C  CB    . GLN A 1 273 ? 3.181   4.391   -6.573  1.000 25.297  0 273 GLN A CB    1 ? 
ATOM   2194 C  CG    . GLN A 1 273 ? 2.243   3.876   -7.661  1.000 25.490  0 273 GLN A CG    1 ? 
ATOM   2195 C  CD    . GLN A 1 273 ? 2.738   4.291   -9.025  1.000 30.234  0 273 GLN A CD    1 ? 
ATOM   2196 O  OE1   . GLN A 1 273 ? 3.910   4.671   -9.202  1.000 25.882  0 273 GLN A OE1   1 ? 
ATOM   2197 N  NE2   . GLN A 1 273 ? 1.837   4.256   -9.993  1.000 31.405  0 273 GLN A NE2   1 ? 
ATOM   2198 N  N     . PRO A 1 274 ? 6.595   4.507   -6.083  1.000 20.246  0 274 PRO A N     1 ? 
ATOM   2199 C  CA    . PRO A 1 274 ? 6.830   4.449   -7.527  1.000 20.815  0 274 PRO A CA    1 ? 
ATOM   2200 C  C     . PRO A 1 274 ? 7.453   3.173   -8.129  1.000 21.345  0 274 PRO A C     1 ? 
ATOM   2201 O  O     . PRO A 1 274 ? 7.869   3.235   -9.278  1.000 19.568  0 274 PRO A O     1 ? 
ATOM   2202 C  CB    . PRO A 1 274 ? 7.763   5.654   -7.734  1.000 20.314  0 274 PRO A CB    1 ? 
ATOM   2203 C  CG    . PRO A 1 274 ? 8.599   5.708   -6.484  1.000 20.671  0 274 PRO A CG    1 ? 
ATOM   2204 C  CD    . PRO A 1 274 ? 7.699   5.170   -5.375  1.000 20.962  0 274 PRO A CD    1 ? 
ATOM   2205 N  N     . TYR A 1 275 ? 7.430   2.044   -7.404  1.000 20.963  0 275 TYR A N     1 ? 
ATOM   2206 C  CA    . TYR A 1 275 ? 7.946   0.710   -7.830  1.000 21.835  0 275 TYR A CA    1 ? 
ATOM   2207 C  C     . TYR A 1 275 ? 9.438   0.791   -8.200  1.000 22.540  0 275 TYR A C     1 ? 
ATOM   2208 O  O     . TYR A 1 275 ? 9.841   0.064   -9.115  1.000 22.287  0 275 TYR A O     1 ? 
ATOM   2209 C  CB    . TYR A 1 275 ? 7.169   0.152   -9.024  1.000 22.789  0 275 TYR A CB    1 ? 
ATOM   2210 C  CG    . TYR A 1 275 ? 5.680   0.083   -8.791  1.000 24.816  0 275 TYR A CG    1 ? 
ATOM   2211 C  CD1   . TYR A 1 275 ? 5.148   -0.806  -7.878  1.000 24.162  0 275 TYR A CD1   1 ? 
ATOM   2212 C  CD2   . TYR A 1 275 ? 4.808   0.909   -9.478  1.000 27.692  0 275 TYR A CD2   1 ? 
ATOM   2213 C  CE1   . TYR A 1 275 ? 3.788   -0.870  -7.640  1.000 25.755  0 275 TYR A CE1   1 ? 
ATOM   2214 C  CE2   . TYR A 1 275 ? 3.441   0.873   -9.240  1.000 28.930  0 275 TYR A CE2   1 ? 
ATOM   2215 C  CZ    . TYR A 1 275 ? 2.931   -0.023  -8.319  1.000 27.670  0 275 TYR A CZ    1 ? 
ATOM   2216 O  OH    . TYR A 1 275 ? 1.594   -0.041  -8.055  1.000 28.956  0 275 TYR A OH    1 ? 
ATOM   2217 N  N     . ASN A 1 276 ? 10.226  1.654   -7.561  1.000 21.167  0 276 ASN A N     1 ? 
ATOM   2218 C  CA    . ASN A 1 276 ? 11.658  1.795   -7.934  1.000 21.474  0 276 ASN A CA    1 ? 
ATOM   2219 C  C     . ASN A 1 276 ? 12.487  0.669   -7.278  1.000 22.584  0 276 ASN A C     1 ? 
ATOM   2220 O  O     . ASN A 1 276 ? 12.108  0.143   -6.189  1.000 20.136  0 276 ASN A O     1 ? 
ATOM   2221 C  CB    . ASN A 1 276 ? 12.207  3.179   -7.591  1.000 23.188  0 276 ASN A CB    1 ? 
ATOM   2222 C  CG    . ASN A 1 276 ? 12.151  3.460   -6.114  1.000 24.788  0 276 ASN A CG    1 ? 
ATOM   2223 O  OD1   . ASN A 1 276 ? 11.077  3.417   -5.511  1.000 28.016  0 276 ASN A OD1   1 ? 
ATOM   2224 N  ND2   . ASN A 1 276 ? 13.305  3.688   -5.514  1.000 29.833  0 276 ASN A ND2   1 ? 
ATOM   2225 N  N     . ASP A 1 277 ? 13.611  0.323   -7.903  1.000 21.038  0 277 ASP A N     1 ? 
ATOM   2226 C  CA    . ASP A 1 277 ? 14.671  -0.494  -7.262  1.000 19.861  0 277 ASP A CA    1 ? 
ATOM   2227 C  C     . ASP A 1 277 ? 15.246  0.283   -6.061  1.000 20.545  0 277 ASP A C     1 ? 
ATOM   2228 O  O     . ASP A 1 277 ? 16.036  1.216   -6.262  1.000 20.494  0 277 ASP A O     1 ? 
ATOM   2229 C  CB    . ASP A 1 277 ? 15.756  -0.875  -8.255  1.000 19.679  0 277 ASP A CB    1 ? 
ATOM   2230 C  CG    . ASP A 1 277 ? 16.831  -1.734  -7.608  1.000 19.625  0 277 ASP A CG    1 ? 
ATOM   2231 O  OD1   . ASP A 1 277 ? 16.566  -2.261  -6.479  1.000 19.408  0 277 ASP A OD1   1 ? 
ATOM   2232 O  OD2   . ASP A 1 277 ? 17.894  -1.888  -8.231  1.000 16.968  0 277 ASP A OD2   1 ? 
ATOM   2233 N  N     . VAL A 1 278 ? 14.864  -0.104  -4.850  1.000 19.852  0 278 VAL A N     1 ? 
ATOM   2234 C  CA    . VAL A 1 278 ? 15.269  0.575   -3.594  1.000 20.500  0 278 VAL A CA    1 ? 
ATOM   2235 C  C     . VAL A 1 278 ? 16.798  0.527   -3.412  1.000 20.373  0 278 VAL A C     1 ? 
ATOM   2236 O  O     . VAL A 1 278 ? 17.306  1.371   -2.700  1.000 20.998  0 278 VAL A O     1 ? 
ATOM   2237 C  CB    . VAL A 1 278 ? 14.517  -0.022  -2.398  1.000 22.322  0 278 VAL A CB    1 ? 
ATOM   2238 C  CG1   . VAL A 1 278 ? 13.026  0.208   -2.547  1.000 24.179  0 278 VAL A CG1   1 ? 
ATOM   2239 C  CG2   . VAL A 1 278 ? 14.810  -1.496  -2.179  1.000 23.322  0 278 VAL A CG2   1 ? 
ATOM   2240 N  N     . PHE A 1 279 ? 17.516  -0.367  -4.090  1.000 21.544  0 279 PHE A N     1 ? 
ATOM   2241 C  CA    . PHE A 1 279 ? 18.998  -0.525  -3.947  1.000 22.913  0 279 PHE A CA    1 ? 
ATOM   2242 C  C     . PHE A 1 279 ? 19.756  0.108   -5.123  1.000 22.645  0 279 PHE A C     1 ? 
ATOM   2243 O  O     . PHE A 1 279 ? 21.000  -0.061  -5.185  1.000 20.148  0 279 PHE A O     1 ? 
ATOM   2244 C  CB    . PHE A 1 279 ? 19.409  -1.997  -3.884  1.000 23.743  0 279 PHE A CB    1 ? 
ATOM   2245 C  CG    . PHE A 1 279 ? 19.129  -2.719  -2.595  1.000 26.227  0 279 PHE A CG    1 ? 
ATOM   2246 C  CD1   . PHE A 1 279 ? 19.445  -2.161  -1.372  1.000 29.092  0 279 PHE A CD1   1 ? 
ATOM   2247 C  CD2   . PHE A 1 279 ? 18.582  -3.984  -2.616  1.000 28.896  0 279 PHE A CD2   1 ? 
ATOM   2248 C  CE1   . PHE A 1 279 ? 19.195  -2.846  -0.194  1.000 30.986  0 279 PHE A CE1   1 ? 
ATOM   2249 C  CE2   . PHE A 1 279 ? 18.323  -4.664  -1.437  1.000 32.722  0 279 PHE A CE2   1 ? 
ATOM   2250 C  CZ    . PHE A 1 279 ? 18.630  -4.096  -0.227  1.000 31.170  0 279 PHE A CZ    1 ? 
ATOM   2251 N  N     . GLU A 1 280 ? 19.063  0.871   -5.976  1.000 22.852  0 280 GLU A N     1 ? 
ATOM   2252 C  CA    . GLU A 1 280 ? 19.600  1.396   -7.259  1.000 24.858  0 280 GLU A CA    1 ? 
ATOM   2253 C  C     . GLU A 1 280 ? 20.787  2.348   -7.014  1.000 23.912  0 280 GLU A C     1 ? 
ATOM   2254 O  O     . GLU A 1 280 ? 21.644  2.413   -7.896  1.000 22.318  0 280 GLU A O     1 ? 
ATOM   2255 C  CB    . GLU A 1 280 ? 18.485  2.078   -8.066  1.000 27.384  0 280 GLU A CB    1 ? 
ATOM   2256 C  CG    . GLU A 1 280 ? 17.969  3.386   -7.470  1.000 29.663  0 280 GLU A CG    1 ? 
ATOM   2257 C  CD    . GLU A 1 280 ? 16.589  3.830   -7.980  1.000 32.839  0 280 GLU A CD    1 ? 
ATOM   2258 O  OE1   . GLU A 1 280 ? 16.168  3.351   -9.056  1.000 33.921  0 280 GLU A OE1   1 ? 
ATOM   2259 O  OE2   . GLU A 1 280 ? 15.904  4.620   -7.267  1.000 35.844  0 280 GLU A OE2   1 ? 
ATOM   2260 N  N     . LYS A 1 281 ? 20.859  3.043   -5.869  1.000 25.661  0 281 LYS A N     1 ? 
ATOM   2261 C  CA    . LYS A 1 281 ? 21.973  3.996   -5.596  1.000 28.453  0 281 LYS A CA    1 ? 
ATOM   2262 C  C     . LYS A 1 281 ? 23.233  3.273   -5.101  1.000 25.520  0 281 LYS A C     1 ? 
ATOM   2263 O  O     . LYS A 1 281 ? 24.254  3.957   -4.969  1.000 28.049  0 281 LYS A O     1 ? 
ATOM   2264 C  CB    . LYS A 1 281 ? 21.570  5.054   -4.570  1.000 33.890  0 281 LYS A CB    1 ? 
ATOM   2265 C  CG    . LYS A 1 281 ? 20.525  6.048   -5.057  1.000 40.321  0 281 LYS A CG    1 ? 
ATOM   2266 C  CD    . LYS A 1 281 ? 20.925  6.767   -6.343  1.000 45.777  0 281 LYS A CD    1 ? 
ATOM   2267 C  CE    . LYS A 1 281 ? 19.952  7.860   -6.748  1.000 52.649  0 281 LYS A CE    1 ? 
ATOM   2268 N  NZ    . LYS A 1 281 ? 18.686  7.294   -7.278  1.000 52.573  0 281 LYS A NZ    1 ? 
ATOM   2269 N  N     . MET A 1 282 ? 23.181  1.980   -4.793  1.000 21.462  0 282 MET A N     1 ? 
ATOM   2270 C  CA    . MET A 1 282 ? 24.382  1.241   -4.326  1.000 21.712  0 282 MET A CA    1 ? 
ATOM   2271 C  C     . MET A 1 282 ? 25.273  0.972   -5.531  1.000 19.513  0 282 MET A C     1 ? 
ATOM   2272 O  O     . MET A 1 282 ? 24.730  0.490   -6.542  1.000 18.967  0 282 MET A O     1 ? 
ATOM   2273 C  CB    . MET A 1 282 ? 24.025  -0.074  -3.644  1.000 24.382  0 282 MET A CB    1 ? 
ATOM   2274 C  CG    . MET A 1 282 ? 23.639  0.135   -2.194  1.000 25.743  0 282 MET A CG    1 ? 
ATOM   2275 S  SD    . MET A 1 282 ? 23.206  -1.401  -1.358  1.000 30.276  0 282 MET A SD    1 ? 
ATOM   2276 C  CE    . MET A 1 282 ? 24.735  -2.287  -1.663  1.000 23.303  0 282 MET A CE    1 ? 
ATOM   2277 N  N     . THR A 1 283 ? 26.584  1.263   -5.440  1.000 17.993  0 283 THR A N     1 ? 
ATOM   2278 C  CA    . THR A 1 283 ? 27.548  0.961   -6.525  1.000 18.394  0 283 THR A CA    1 ? 
ATOM   2279 C  C     . THR A 1 283 ? 27.739  -0.563  -6.680  1.000 18.106  0 283 THR A C     1 ? 
ATOM   2280 O  O     . THR A 1 283 ? 27.287  -1.362  -5.813  1.000 16.600  0 283 THR A O     1 ? 
ATOM   2281 C  CB    . THR A 1 283 ? 28.923  1.627   -6.328  1.000 20.526  0 283 THR A CB    1 ? 
ATOM   2282 O  OG1   . THR A 1 283 ? 29.571  0.907   -5.280  1.000 21.404  0 283 THR A OG1   1 ? 
ATOM   2283 C  CG2   . THR A 1 283 ? 28.844  3.111   -6.005  1.000 19.999  0 283 THR A CG2   1 ? 
ATOM   2284 N  N     . GLY A 1 284 ? 28.346  -0.961  -7.793  1.000 15.879  0 284 GLY A N     1 ? 
ATOM   2285 C  CA    . GLY A 1 284 ? 28.773  -2.348  -8.020  1.000 16.490  0 284 GLY A CA    1 ? 
ATOM   2286 C  C     . GLY A 1 284 ? 29.669  -2.845  -6.903  1.000 15.662  0 284 GLY A C     1 ? 
ATOM   2287 O  O     . GLY A 1 284 ? 29.455  -3.963  -6.438  1.000 16.953  0 284 GLY A O     1 ? 
ATOM   2288 N  N     . MET A 1 285 ? 30.643  -2.050  -6.452  1.000 16.547  0 285 MET A N     1 ? 
ATOM   2289 C  CA    . MET A 1 285 ? 31.587  -2.509  -5.399  1.000 16.091  0 285 MET A CA    1 ? 
ATOM   2290 C  C     . MET A 1 285 ? 30.828  -2.643  -4.074  1.000 15.840  0 285 MET A C     1 ? 
ATOM   2291 O  O     . MET A 1 285 ? 31.125  -3.573  -3.294  1.000 15.494  0 285 MET A O     1 ? 
ATOM   2292 C  CB    . MET A 1 285 ? 32.757  -1.538  -5.255  1.000 18.560  0 285 MET A CB    1 ? 
ATOM   2293 C  CG    . MET A 1 285 ? 33.735  -1.589  -6.447  1.000 20.121  0 285 MET A CG    1 ? 
ATOM   2294 S  SD    . MET A 1 285 ? 34.646  -3.165  -6.435  1.000 22.580  0 285 MET A SD    1 ? 
ATOM   2295 C  CE    . MET A 1 285 ? 35.936  -2.838  -7.630  1.000 28.806  0 285 MET A CE    1 ? 
ATOM   2296 N  N     . GLN A 1 286 ? 29.854  -1.777  -3.829  1.000 15.979  0 286 GLN A N     1 ? 
ATOM   2297 C  CA    . GLN A 1 286 ? 29.103  -1.811  -2.550  1.000 16.919  0 286 GLN A CA    1 ? 
ATOM   2298 C  C     . GLN A 1 286 ? 28.221  -3.041  -2.585  1.000 16.400  0 286 GLN A C     1 ? 
ATOM   2299 O  O     . GLN A 1 286 ? 28.128  -3.750  -1.568  1.000 16.661  0 286 GLN A O     1 ? 
ATOM   2300 C  CB    . GLN A 1 286 ? 28.296  -0.537  -2.353  1.000 17.217  0 286 GLN A CB    1 ? 
ATOM   2301 C  CG    . GLN A 1 286 ? 29.184  0.633   -1.957  1.000 18.607  0 286 GLN A CG    1 ? 
ATOM   2302 C  CD    . GLN A 1 286 ? 28.521  1.958   -2.213  1.000 20.038  0 286 GLN A CD    1 ? 
ATOM   2303 O  OE1   . GLN A 1 286 ? 27.430  2.038   -2.763  1.000 17.849  0 286 GLN A OE1   1 ? 
ATOM   2304 N  NE2   . GLN A 1 286 ? 29.182  3.023   -1.805  1.000 23.363  0 286 GLN A NE2   1 ? 
ATOM   2305 N  N     . MET A 1 287 ? 27.633  -3.306  -3.742  1.000 15.044  0 287 MET A N     1 ? 
ATOM   2306 C  CA    . MET A 1 287 ? 26.875  -4.559  -3.977  1.000 14.752  0 287 MET A CA    1 ? 
ATOM   2307 C  C     . MET A 1 287 ? 27.779  -5.785  -3.784  1.000 13.911  0 287 MET A C     1 ? 
ATOM   2308 O  O     . MET A 1 287 ? 27.295  -6.756  -3.213  1.000 12.801  0 287 MET A O     1 ? 
ATOM   2309 C  CB    . MET A 1 287 ? 26.256  -4.568  -5.371  1.000 14.084  0 287 MET A CB    1 ? 
ATOM   2310 C  CG    . MET A 1 287 ? 24.950  -3.832  -5.409  1.000 14.509  0 287 MET A CG    1 ? 
ATOM   2311 S  SD    . MET A 1 287 ? 23.735  -4.878  -4.596  1.000 17.523  0 287 MET A SD    1 ? 
ATOM   2312 C  CE    . MET A 1 287 ? 22.338  -3.753  -4.573  1.000 18.934  0 287 MET A CE    1 ? 
ATOM   2313 N  N     . GLU A 1 288 ? 29.042  -5.751  -4.231  1.000 13.047  0 288 GLU A N     1 ? 
ATOM   2314 C  CA    . GLU A 1 288 ? 29.969  -6.907  -4.073  1.000 14.290  0 288 GLU A CA    1 ? 
ATOM   2315 C  C     . GLU A 1 288 ? 30.209  -7.171  -2.580  1.000 14.272  0 288 GLU A C     1 ? 
ATOM   2316 O  O     . GLU A 1 288 ? 30.088  -8.320  -2.131  1.000 15.219  0 288 GLU A O     1 ? 
ATOM   2317 C  CB    . GLU A 1 288 ? 31.264  -6.659  -4.831  1.000 15.372  0 288 GLU A CB    1 ? 
ATOM   2318 C  CG    . GLU A 1 288 ? 32.222  -7.844  -4.774  1.000 17.569  0 288 GLU A CG    1 ? 
ATOM   2319 C  CD    . GLU A 1 288 ? 33.507  -7.563  -5.519  1.000 19.000  0 288 GLU A CD    1 ? 
ATOM   2320 O  OE1   . GLU A 1 288 ? 34.247  -6.651  -5.101  1.000 19.905  0 288 GLU A OE1   1 ? 
ATOM   2321 O  OE2   . GLU A 1 288 ? 33.718  -8.189  -6.554  1.000 20.906  0 288 GLU A OE2   1 ? 
ATOM   2322 N  N     . SER A 1 289 ? 30.450  -6.130  -1.807  1.000 15.851  0 289 SER A N     1 ? 
ATOM   2323 C  CA    . SER A 1 289 ? 30.747  -6.268  -0.366  1.000 17.288  0 289 SER A CA    1 ? 
ATOM   2324 C  C     . SER A 1 289 ? 29.478  -6.734  0.363   1.000 16.350  0 289 SER A C     1 ? 
ATOM   2325 O  O     . SER A 1 289 ? 29.591  -7.470  1.316   1.000 18.372  0 289 SER A O     1 ? 
ATOM   2326 C  CB    . SER A 1 289 ? 31.293  -4.975  0.171   1.000 19.245  0 289 SER A CB    1 ? 
ATOM   2327 O  OG    . SER A 1 289 ? 31.639  -5.114  1.543   1.000 23.448  0 289 SER A OG    1 ? 
ATOM   2328 N  N     . PHE A 1 290 ? 28.321  -6.222  -0.022  1.000 15.665  0 290 PHE A N     1 ? 
ATOM   2329 C  CA    . PHE A 1 290 ? 26.995  -6.575  0.551   1.000 17.422  0 290 PHE A CA    1 ? 
ATOM   2330 C  C     . PHE A 1 290 ? 26.828  -8.084  0.437   1.000 16.627  0 290 PHE A C     1 ? 
ATOM   2331 O  O     . PHE A 1 290 ? 26.617  -8.763  1.457   1.000 16.788  0 290 PHE A O     1 ? 
ATOM   2332 C  CB    . PHE A 1 290 ? 25.892  -5.790  -0.181  1.000 18.235  0 290 PHE A CB    1 ? 
ATOM   2333 C  CG    . PHE A 1 290 ? 24.454  -6.049  0.214   1.000 19.775  0 290 PHE A CG    1 ? 
ATOM   2334 C  CD1   . PHE A 1 290 ? 24.117  -6.611  1.440   1.000 19.026  0 290 PHE A CD1   1 ? 
ATOM   2335 C  CD2   . PHE A 1 290 ? 23.422  -5.621  -0.623  1.000 20.828  0 290 PHE A CD2   1 ? 
ATOM   2336 C  CE1   . PHE A 1 290 ? 22.781  -6.814  1.781   1.000 21.329  0 290 PHE A CE1   1 ? 
ATOM   2337 C  CE2   . PHE A 1 290 ? 22.090  -5.835  -0.289  1.000 21.405  0 290 PHE A CE2   1 ? 
ATOM   2338 C  CZ    . PHE A 1 290 ? 21.771  -6.420  0.917   1.000 21.530  0 290 PHE A CZ    1 ? 
ATOM   2339 N  N     . LYS A 1 291 ? 26.991  -8.599  -0.784  1.000 18.372  0 291 LYS A N     1 ? 
ATOM   2340 C  CA    . LYS A 1 291 ? 26.802  -10.048 -1.082  1.000 18.296  0 291 LYS A CA    1 ? 
ATOM   2341 C  C     . LYS A 1 291 ? 27.769  -10.877 -0.223  1.000 17.591  0 291 LYS A C     1 ? 
ATOM   2342 O  O     . LYS A 1 291 ? 27.312  -11.905 0.326   1.000 16.330  0 291 LYS A O     1 ? 
ATOM   2343 C  CB    . LYS A 1 291 ? 26.983  -10.348 -2.574  1.000 17.300  0 291 LYS A CB    1 ? 
ATOM   2344 C  CG    . LYS A 1 291 ? 26.421  -11.699 -2.982  1.000 17.991  0 291 LYS A CG    1 ? 
ATOM   2345 C  CD    . LYS A 1 291 ? 26.669  -12.090 -4.421  1.000 18.688  0 291 LYS A CD    1 ? 
ATOM   2346 C  CE    . LYS A 1 291 ? 25.901  -13.349 -4.787  1.000 19.645  0 291 LYS A CE    1 ? 
ATOM   2347 N  NZ    . LYS A 1 291 ? 26.266  -13.856 -6.130  1.000 20.003  0 291 LYS A NZ    1 ? 
ATOM   2348 N  N     . SER A 1 292 ? 29.032  -10.446 -0.070  1.000 15.818  0 292 SER A N     1 ? 
ATOM   2349 C  CA    . SER A 1 292 ? 30.063  -11.230 0.654   1.000 17.381  0 292 SER A CA    1 ? 
ATOM   2350 C  C     . SER A 1 292 ? 29.688  -11.297 2.131   1.000 15.409  0 292 SER A C     1 ? 
ATOM   2351 O  O     . SER A 1 292 ? 29.756  -12.371 2.693   1.000 16.476  0 292 SER A O     1 ? 
ATOM   2352 C  CB    . SER A 1 292 ? 31.461  -10.684 0.472   1.000 19.005  0 292 SER A CB    1 ? 
ATOM   2353 O  OG    . SER A 1 292 ? 31.748  -10.595 -0.909  1.000 24.650  0 292 SER A OG    1 ? 
ATOM   2354 N  N     . LYS A 1 293 ? 29.261  -10.189 2.727   1.000 16.036  0 293 LYS A N     1 ? 
ATOM   2355 C  CA    . LYS A 1 293 ? 28.851  -10.216 4.158   1.000 15.449  0 293 LYS A CA    1 ? 
ATOM   2356 C  C     . LYS A 1 293 ? 27.558  -11.016 4.297   1.000 16.473  0 293 LYS A C     1 ? 
ATOM   2357 O  O     . LYS A 1 293 ? 27.407  -11.675 5.343   1.000 16.497  0 293 LYS A O     1 ? 
ATOM   2358 C  CB    . LYS A 1 293 ? 28.755  -8.798  4.718   1.000 16.018  0 293 LYS A CB    1 ? 
ATOM   2359 C  CG    . LYS A 1 293 ? 30.096  -8.088  4.799   1.000 15.168  0 293 LYS A CG    1 ? 
ATOM   2360 C  CD    . LYS A 1 293 ? 30.006  -6.708  5.394   1.000 16.231  0 293 LYS A CD    1 ? 
ATOM   2361 C  CE    . LYS A 1 293 ? 30.167  -5.602  4.377   1.000 16.759  0 293 LYS A CE    1 ? 
ATOM   2362 N  NZ    . LYS A 1 293 ? 30.290  -4.276  5.013   1.000 16.309  0 293 LYS A NZ    1 ? 
ATOM   2363 N  N     . LEU A 1 294 ? 26.606  -10.857 3.361   1.000 18.162  0 294 LEU A N     1 ? 
ATOM   2364 C  CA    . LEU A 1 294 ? 25.334  -11.652 3.337   1.000 18.046  0 294 LEU A CA    1 ? 
ATOM   2365 C  C     . LEU A 1 294 ? 25.697  -13.155 3.320   1.000 16.708  0 294 LEU A C     1 ? 
ATOM   2366 O  O     . LEU A 1 294 ? 25.149  -13.939 4.117   1.000 13.888  0 294 LEU A O     1 ? 
ATOM   2367 C  CB    . LEU A 1 294 ? 24.531  -11.218 2.108   1.000 19.434  0 294 LEU A CB    1 ? 
ATOM   2368 C  CG    . LEU A 1 294 ? 22.997  -11.137 2.179   1.000 20.873  0 294 LEU A CG    1 ? 
ATOM   2369 C  CD1   . LEU A 1 294 ? 22.438  -10.746 3.538   1.000 21.227  0 294 LEU A CD1   1 ? 
ATOM   2370 C  CD2   . LEU A 1 294 ? 22.507  -10.182 1.098   1.000 22.054  0 294 LEU A CD2   1 ? 
ATOM   2371 N  N     . GLN A 1 295 ? 26.652  -13.543 2.482   1.000 16.013  0 295 GLN A N     1 ? 
ATOM   2372 C  CA    . GLN A 1 295 ? 27.136  -14.929 2.406   1.000 15.845  0 295 GLN A CA    1 ? 
ATOM   2373 C  C     . GLN A 1 295 ? 27.809  -15.332 3.728   1.000 14.689  0 295 GLN A C     1 ? 
ATOM   2374 O  O     . GLN A 1 295 ? 27.608  -16.464 4.144   1.000 13.556  0 295 GLN A O     1 ? 
ATOM   2375 C  CB    . GLN A 1 295 ? 28.049  -15.127 1.201   1.000 17.712  0 295 GLN A CB    1 ? 
ATOM   2376 C  CG    . GLN A 1 295 ? 28.482  -16.575 1.017   1.000 20.324  0 295 GLN A CG    1 ? 
ATOM   2377 C  CD    . GLN A 1 295 ? 27.325  -17.430 0.536   1.000 23.203  0 295 GLN A CD    1 ? 
ATOM   2378 O  OE1   . GLN A 1 295 ? 26.675  -17.113 -0.462  1.000 24.046  0 295 GLN A OE1   1 ? 
ATOM   2379 N  NE2   . GLN A 1 295 ? 27.020  -18.486 1.273   1.000 21.342  0 295 GLN A NE2   1 ? 
ATOM   2380 N  N     . ALA A 1 296 ? 28.626  -14.488 4.344   1.000 14.646  0 296 ALA A N     1 ? 
ATOM   2381 C  CA    . ALA A 1 296 ? 29.312  -14.873 5.586   1.000 14.206  0 296 ALA A CA    1 ? 
ATOM   2382 C  C     . ALA A 1 296 ? 28.230  -15.040 6.659   1.000 14.851  0 296 ALA A C     1 ? 
ATOM   2383 O  O     . ALA A 1 296 ? 28.361  -15.934 7.477   1.000 14.404  0 296 ALA A O     1 ? 
ATOM   2384 C  CB    . ALA A 1 296 ? 30.347  -13.842 5.966   1.000 15.451  0 296 ALA A CB    1 ? 
ATOM   2385 N  N     . LEU A 1 297 ? 27.147  -14.263 6.596   1.000 14.377  0 297 LEU A N     1 ? 
ATOM   2386 C  CA    . LEU A 1 297 ? 26.067  -14.372 7.620   1.000 14.735  0 297 LEU A CA    1 ? 
ATOM   2387 C  C     . LEU A 1 297 ? 25.302  -15.679 7.398   1.000 13.407  0 297 LEU A C     1 ? 
ATOM   2388 O  O     . LEU A 1 297 ? 25.176  -16.439 8.354   1.000 12.803  0 297 LEU A O     1 ? 
ATOM   2389 C  CB    . LEU A 1 297 ? 25.164  -13.136 7.582   1.000 15.393  0 297 LEU A CB    1 ? 
ATOM   2390 C  CG    . LEU A 1 297 ? 23.841  -13.286 8.324   1.000 16.507  0 297 LEU A CG    1 ? 
ATOM   2391 C  CD1   . LEU A 1 297 ? 24.105  -13.455 9.807   1.000 16.502  0 297 LEU A CD1   1 ? 
ATOM   2392 C  CD2   . LEU A 1 297 ? 22.963  -12.077 8.081   1.000 18.233  0 297 LEU A CD2   1 ? 
ATOM   2393 N  N     . LEU A 1 298 ? 24.909  -15.986 6.162   1.000 14.055  0 298 LEU A N     1 ? 
ATOM   2394 C  CA    . LEU A 1 298 ? 24.412  -17.332 5.778   1.000 15.949  0 298 LEU A CA    1 ? 
ATOM   2395 C  C     . LEU A 1 298 ? 25.320  -18.430 6.368   1.000 16.494  0 298 LEU A C     1 ? 
ATOM   2396 O  O     . LEU A 1 298 ? 24.784  -19.370 7.002   1.000 13.171  0 298 LEU A O     1 ? 
ATOM   2397 C  CB    . LEU A 1 298 ? 24.391  -17.442 4.252   1.000 16.692  0 298 LEU A CB    1 ? 
ATOM   2398 C  CG    . LEU A 1 298 ? 23.626  -18.630 3.656   1.000 18.980  0 298 LEU A CG    1 ? 
ATOM   2399 C  CD1   . LEU A 1 298 ? 24.511  -19.844 3.518   1.000 22.808  0 298 LEU A CD1   1 ? 
ATOM   2400 C  CD2   . LEU A 1 298 ? 22.403  -18.982 4.471   1.000 20.456  0 298 LEU A CD2   1 ? 
ATOM   2401 N  N     . ASN A 1 299 ? 26.641  -18.332 6.141   1.000 16.976  0 299 ASN A N     1 ? 
ATOM   2402 C  CA    . ASN A 1 299 ? 27.611  -19.389 6.550   1.000 16.644  0 299 ASN A CA    1 ? 
ATOM   2403 C  C     . ASN A 1 299 ? 27.557  -19.530 8.067   1.000 15.496  0 299 ASN A C     1 ? 
ATOM   2404 O  O     . ASN A 1 299 ? 27.482  -20.714 8.541   1.000 15.364  0 299 ASN A O     1 ? 
ATOM   2405 C  CB    . ASN A 1 299 ? 29.021  -19.121 6.013   1.000 20.255  0 299 ASN A CB    1 ? 
ATOM   2406 C  CG    . ASN A 1 299 ? 29.100  -19.212 4.506   1.000 23.091  0 299 ASN A CG    1 ? 
ATOM   2407 O  OD1   . ASN A 1 299 ? 28.154  -19.675 3.841   1.000 22.488  0 299 ASN A OD1   1 ? 
ATOM   2408 N  ND2   . ASN A 1 299 ? 30.215  -18.759 3.955   1.000 23.295  0 299 ASN A ND2   1 ? 
ATOM   2409 N  N     . ALA A 1 300 ? 27.458  -18.401 8.792   1.000 15.272  0 300 ALA A N     1 ? 
ATOM   2410 C  CA    . ALA A 1 300 ? 27.265  -18.365 10.265  1.000 16.842  0 300 ALA A CA    1 ? 
ATOM   2411 C  C     . ALA A 1 300 ? 25.971  -19.080 10.681  1.000 15.822  0 300 ALA A C     1 ? 
ATOM   2412 O  O     . ALA A 1 300 ? 26.016  -19.883 11.630  1.000 14.357  0 300 ALA A O     1 ? 
ATOM   2413 C  CB    . ALA A 1 300 ? 27.309  -16.952 10.814  1.000 18.378  0 300 ALA A CB    1 ? 
ATOM   2414 N  N     . LEU A 1 301 ? 24.859  -18.809 10.023  1.000 17.995  0 301 LEU A N     1 ? 
ATOM   2415 C  CA    . LEU A 1 301 ? 23.541  -19.375 10.436  1.000 18.509  0 301 LEU A CA    1 ? 
ATOM   2416 C  C     . LEU A 1 301 ? 23.551  -20.912 10.322  1.000 19.426  0 301 LEU A C     1 ? 
ATOM   2417 O  O     . LEU A 1 301 ? 22.990  -21.604 11.207  1.000 19.795  0 301 LEU A O     1 ? 
ATOM   2418 C  CB    . LEU A 1 301 ? 22.467  -18.741 9.563   1.000 17.863  0 301 LEU A CB    1 ? 
ATOM   2419 C  CG    . LEU A 1 301 ? 22.141  -17.290 9.909   1.000 16.727  0 301 LEU A CG    1 ? 
ATOM   2420 C  CD1   . LEU A 1 301 ? 21.423  -16.615 8.752   1.000 17.177  0 301 LEU A CD1   1 ? 
ATOM   2421 C  CD2   . LEU A 1 301 ? 21.310  -17.174 11.179  1.000 17.118  0 301 LEU A CD2   1 ? 
ATOM   2422 N  N     . LYS A 1 302 ? 24.191  -21.419 9.286   1.000 20.406  0 302 LYS A N     1 ? 
ATOM   2423 C  CA    . LYS A 1 302 ? 24.379  -22.864 9.052   1.000 21.669  0 302 LYS A CA    1 ? 
ATOM   2424 C  C     . LYS A 1 302 ? 25.328  -23.415 10.114  1.000 21.738  0 302 LYS A C     1 ? 
ATOM   2425 O  O     . LYS A 1 302 ? 25.022  -24.488 10.654  1.000 24.320  0 302 LYS A O     1 ? 
ATOM   2426 C  CB    . LYS A 1 302 ? 24.888  -23.097 7.626   1.000 22.352  0 302 LYS A CB    1 ? 
ATOM   2427 C  CG    . LYS A 1 302 ? 23.877  -22.833 6.522   1.000 23.890  0 302 LYS A CG    1 ? 
ATOM   2428 C  CD    . LYS A 1 302 ? 24.345  -23.442 5.228   1.000 26.778  0 302 LYS A CD    1 ? 
ATOM   2429 C  CE    . LYS A 1 302 ? 23.467  -23.165 4.041   1.000 28.537  0 302 LYS A CE    1 ? 
ATOM   2430 N  NZ    . LYS A 1 302 ? 24.219  -23.463 2.803   1.000 29.893  0 302 LYS A NZ    1 ? 
ATOM   2431 N  N     . THR A 1 303 ? 26.412  -22.711 10.437  1.000 22.166  0 303 THR A N     1 ? 
ATOM   2432 C  CA    . THR A 1 303 ? 27.437  -23.202 11.399  1.000 22.730  0 303 THR A CA    1 ? 
ATOM   2433 C  C     . THR A 1 303 ? 26.748  -23.296 12.748  1.000 25.150  0 303 THR A C     1 ? 
ATOM   2434 O  O     . THR A 1 303 ? 26.935  -24.305 13.443  1.000 26.859  0 303 THR A O     1 ? 
ATOM   2435 C  CB    . THR A 1 303 ? 28.683  -22.311 11.448  1.000 23.698  0 303 THR A CB    1 ? 
ATOM   2436 O  OG1   . THR A 1 303 ? 29.297  -22.379 10.164  1.000 23.806  0 303 THR A OG1   1 ? 
ATOM   2437 C  CG2   . THR A 1 303 ? 29.701  -22.718 12.490  1.000 23.379  0 303 THR A CG2   1 ? 
ATOM   2438 N  N     . ALA A 1 304 ? 25.956  -22.276 13.082  1.000 25.315  0 304 ALA A N     1 ? 
ATOM   2439 C  CA    . ALA A 1 304 ? 25.252  -22.172 14.373  1.000 24.700  0 304 ALA A CA    1 ? 
ATOM   2440 C  C     . ALA A 1 304 ? 24.469  -23.473 14.587  1.000 27.598  0 304 ALA A C     1 ? 
ATOM   2441 O  O     . ALA A 1 304 ? 24.580  -24.046 15.673  1.000 29.571  0 304 ALA A O     1 ? 
ATOM   2442 C  CB    . ALA A 1 304 ? 24.369  -20.950 14.368  1.000 24.109  0 304 ALA A CB    1 ? 
ATOM   2443 N  N     . LYS A 1 305 ? 23.794  -23.953 13.542  1.000 29.042  0 305 LYS A N     1 ? 
ATOM   2444 C  CA    . LYS A 1 305 ? 22.889  -25.131 13.573  1.000 29.620  0 305 LYS A CA    1 ? 
ATOM   2445 C  C     . LYS A 1 305 ? 23.661  -26.366 14.026  1.000 31.026  0 305 LYS A C     1 ? 
ATOM   2446 O  O     . LYS A 1 305 ? 23.102  -27.170 14.756  1.000 30.115  0 305 LYS A O     1 ? 
ATOM   2447 C  CB    . LYS A 1 305 ? 22.301  -25.385 12.184  1.000 31.578  0 305 LYS A CB    1 ? 
ATOM   2448 C  CG    . LYS A 1 305 ? 21.167  -26.403 12.138  1.000 32.508  0 305 LYS A CG    1 ? 
ATOM   2449 C  CD    . LYS A 1 305 ? 20.587  -26.597 10.741  1.000 35.637  0 305 LYS A CD    1 ? 
ATOM   2450 C  CE    . LYS A 1 305 ? 19.248  -27.310 10.726  1.000 37.539  0 305 LYS A CE    1 ? 
ATOM   2451 N  NZ    . LYS A 1 305 ? 18.876  -27.737 9.352   1.000 37.961  0 305 LYS A NZ    1 ? 
ATOM   2452 N  N     . SER A 1 306 ? 24.894  -26.528 13.558  1.000 30.240  0 306 SER A N     1 ? 
ATOM   2453 C  CA    . SER A 1 306 ? 25.629  -27.812 13.670  1.000 29.645  0 306 SER A CA    1 ? 
ATOM   2454 C  C     . SER A 1 306 ? 26.568  -27.791 14.889  1.000 31.293  0 306 SER A C     1 ? 
ATOM   2455 O  O     . SER A 1 306 ? 27.206  -28.812 15.134  1.000 30.510  0 306 SER A O     1 ? 
ATOM   2456 C  CB    . SER A 1 306 ? 26.346  -28.129 12.378  1.000 28.900  0 306 SER A CB    1 ? 
ATOM   2457 O  OG    . SER A 1 306 ? 27.431  -27.235 12.166  1.000 26.542  0 306 SER A OG    1 ? 
ATOM   2458 N  N     . ARG A 1 307 ? 26.648  -26.683 15.641  1.000 29.945  0 307 ARG A N     1 ? 
ATOM   2459 C  CA    . ARG A 1 307 ? 27.503  -26.601 16.856  1.000 28.887  0 307 ARG A CA    1 ? 
ATOM   2460 C  C     . ARG A 1 307 ? 26.871  -27.453 17.961  1.000 30.397  0 307 ARG A C     1 ? 
ATOM   2461 O  O     . ARG A 1 307 ? 25.669  -27.368 18.109  1.000 32.002  0 307 ARG A O     1 ? 
ATOM   2462 C  CB    . ARG A 1 307 ? 27.639  -25.165 17.368  1.000 27.428  0 307 ARG A CB    1 ? 
ATOM   2463 C  CG    . ARG A 1 307 ? 28.445  -24.222 16.482  1.000 26.320  0 307 ARG A CG    1 ? 
ATOM   2464 C  CD    . ARG A 1 307 ? 29.759  -24.776 15.976  1.000 23.776  0 307 ARG A CD    1 ? 
ATOM   2465 N  NE    . ARG A 1 307 ? 29.532  -25.558 14.778  1.000 23.658  0 307 ARG A NE    1 ? 
ATOM   2466 C  CZ    . ARG A 1 307 ? 30.439  -26.333 14.192  1.000 25.921  0 307 ARG A CZ    1 ? 
ATOM   2467 N  NH1   . ARG A 1 307 ? 30.125  -27.008 13.093  1.000 22.545  0 307 ARG A NH1   1 ? 
ATOM   2468 N  NH2   . ARG A 1 307 ? 31.649  -26.447 14.725  1.000 26.781  0 307 ARG A NH2   1 ? 
ATOM   2469 N  N     . LEU A 1 308 ? 27.678  -28.192 18.719  1.000 27.723  0 308 LEU A N     1 ? 
ATOM   2470 C  CA    . LEU A 1 308 ? 27.251  -29.094 19.821  1.000 28.526  0 308 LEU A CA    1 ? 
ATOM   2471 C  C     . LEU A 1 308 ? 27.009  -28.282 21.091  1.000 28.286  0 308 LEU A C     1 ? 
ATOM   2472 O  O     . LEU A 1 308 ? 26.142  -28.665 21.922  1.000 31.037  0 308 LEU A O     1 ? 
ATOM   2473 C  CB    . LEU A 1 308 ? 28.368  -30.116 20.045  1.000 30.388  0 308 LEU A CB    1 ? 
ATOM   2474 C  CG    . LEU A 1 308 ? 28.515  -31.142 18.922  1.000 32.357  0 308 LEU A CG    1 ? 
ATOM   2475 C  CD1   . LEU A 1 308 ? 29.685  -32.097 19.185  1.000 34.776  0 308 LEU A CD1   1 ? 
ATOM   2476 C  CD2   . LEU A 1 308 ? 27.202  -31.898 18.731  1.000 30.560  0 308 LEU A CD2   1 ? 
ATOM   2477 N  N     . GLU A 1 309 ? 27.791  -27.229 21.237  1.000 27.030  0 309 GLU A N     1 ? 
ATOM   2478 C  CA    . GLU A 1 309 ? 27.790  -26.309 22.386  1.000 28.862  0 309 GLU A CA    1 ? 
ATOM   2479 C  C     . GLU A 1 309 ? 26.952  -25.081 22.012  1.000 28.316  0 309 GLU A C     1 ? 
ATOM   2480 O  O     . GLU A 1 309 ? 27.287  -24.429 20.995  1.000 24.562  0 309 GLU A O     1 ? 
ATOM   2481 C  CB    . GLU A 1 309 ? 29.228  -25.888 22.676  1.000 34.457  0 309 GLU A CB    1 ? 
ATOM   2482 C  CG    . GLU A 1 309 ? 29.465  -25.519 24.113  1.000 41.367  0 309 GLU A CG    1 ? 
ATOM   2483 C  CD    . GLU A 1 309 ? 29.906  -26.713 24.941  1.000 49.349  0 309 GLU A CD    1 ? 
ATOM   2484 O  OE1   . GLU A 1 309 ? 31.012  -27.238 24.664  1.000 55.054  0 309 GLU A OE1   1 ? 
ATOM   2485 O  OE2   . GLU A 1 309 ? 29.128  -27.141 25.829  1.000 57.330  0 309 GLU A OE2   1 ? 
ATOM   2486 N  N     . LEU A 1 310 ? 25.958  -24.733 22.831  1.000 25.697  0 310 LEU A N     1 ? 
ATOM   2487 C  CA    . LEU A 1 310 ? 25.229  -23.436 22.716  1.000 24.560  0 310 LEU A CA    1 ? 
ATOM   2488 C  C     . LEU A 1 310 ? 26.221  -22.258 22.651  1.000 24.321  0 310 LEU A C     1 ? 
ATOM   2489 O  O     . LEU A 1 310 ? 25.998  -21.336 21.825  1.000 21.180  0 310 LEU A O     1 ? 
ATOM   2490 C  CB    . LEU A 1 310 ? 24.255  -23.273 23.884  1.000 24.632  0 310 LEU A CB    1 ? 
ATOM   2491 C  CG    . LEU A 1 310 ? 23.328  -22.067 23.762  1.000 25.180  0 310 LEU A CG    1 ? 
ATOM   2492 C  CD1   . LEU A 1 310 ? 22.565  -22.115 22.461  1.000 25.361  0 310 LEU A CD1   1 ? 
ATOM   2493 C  CD2   . LEU A 1 310 ? 22.363  -21.986 24.931  1.000 26.225  0 310 LEU A CD2   1 ? 
ATOM   2494 N  N     . HIS A 1 311 ? 27.260  -22.250 23.489  1.000 23.397  0 311 HIS A N     1 ? 
ATOM   2495 C  CA    . HIS A 1 311 ? 28.294  -21.178 23.492  1.000 23.080  0 311 HIS A CA    1 ? 
ATOM   2496 C  C     . HIS A 1 311 ? 28.849  -20.955 22.070  1.000 23.402  0 311 HIS A C     1 ? 
ATOM   2497 O  O     . HIS A 1 311 ? 28.888  -19.791 21.643  1.000 24.038  0 311 HIS A O     1 ? 
ATOM   2498 C  CB    . HIS A 1 311 ? 29.426  -21.466 24.486  1.000 23.580  0 311 HIS A CB    1 ? 
ATOM   2499 C  CG    . HIS A 1 311 ? 30.619  -20.584 24.278  1.000 22.810  0 311 HIS A CG    1 ? 
ATOM   2500 N  ND1   . HIS A 1 311 ? 30.811  -19.408 24.985  1.000 23.308  0 311 HIS A ND1   1 ? 
ATOM   2501 C  CD2   . HIS A 1 311 ? 31.661  -20.682 23.417  1.000 22.496  0 311 HIS A CD2   1 ? 
ATOM   2502 C  CE1   . HIS A 1 311 ? 31.908  -18.812 24.543  1.000 23.527  0 311 HIS A CE1   1 ? 
ATOM   2503 N  NE2   . HIS A 1 311 ? 32.443  -19.573 23.590  1.000 21.345  0 311 HIS A NE2   1 ? 
ATOM   2504 N  N     . ASP A 1 312 ? 29.332  -21.999 21.390  1.000 23.157  0 312 ASP A N     1 ? 
ATOM   2505 C  CA    . ASP A 1 312 ? 29.947  -21.856 20.037  1.000 21.525  0 312 ASP A CA    1 ? 
ATOM   2506 C  C     . ASP A 1 312 ? 28.876  -21.397 19.030  1.000 21.902  0 312 ASP A C     1 ? 
ATOM   2507 O  O     . ASP A 1 312 ? 29.211  -20.683 18.089  1.000 21.989  0 312 ASP A O     1 ? 
ATOM   2508 C  CB    . ASP A 1 312 ? 30.602  -23.145 19.550  1.000 21.483  0 312 ASP A CB    1 ? 
ATOM   2509 C  CG    . ASP A 1 312 ? 31.706  -23.676 20.443  1.000 22.806  0 312 ASP A CG    1 ? 
ATOM   2510 O  OD1   . ASP A 1 312 ? 32.209  -22.912 21.238  1.000 22.426  0 312 ASP A OD1   1 ? 
ATOM   2511 O  OD2   . ASP A 1 312 ? 31.993  -24.881 20.368  1.000 26.151  0 312 ASP A OD2   1 ? 
ATOM   2512 N  N     . ALA A 1 313 ? 27.639  -21.857 19.156  1.000 22.907  0 313 ALA A N     1 ? 
ATOM   2513 C  CA    . ALA A 1 313 ? 26.559  -21.507 18.201  1.000 23.224  0 313 ALA A CA    1 ? 
ATOM   2514 C  C     . ALA A 1 313 ? 26.292  -20.004 18.302  1.000 21.836  0 313 ALA A C     1 ? 
ATOM   2515 O  O     . ALA A 1 313 ? 26.171  -19.339 17.283  1.000 26.026  0 313 ALA A O     1 ? 
ATOM   2516 C  CB    . ALA A 1 313 ? 25.326  -22.314 18.504  1.000 22.279  0 313 ALA A CB    1 ? 
ATOM   2517 N  N     . CYS A 1 314 ? 26.279  -19.487 19.519  1.000 20.086  0 314 CYS A N     1 ? 
ATOM   2518 C  CA    . CYS A 1 314 ? 25.905  -18.094 19.841  1.000 19.527  0 314 CYS A CA    1 ? 
ATOM   2519 C  C     . CYS A 1 314 ? 27.079  -17.179 19.467  1.000 19.323  0 314 CYS A C     1 ? 
ATOM   2520 O  O     . CYS A 1 314 ? 26.842  -16.114 18.892  1.000 15.744  0 314 CYS A O     1 ? 
ATOM   2521 C  CB    . CYS A 1 314 ? 25.482  -18.006 21.302  1.000 18.747  0 314 CYS A CB    1 ? 
ATOM   2522 S  SG    . CYS A 1 314 ? 23.840  -18.743 21.559  1.000 20.704  0 314 CYS A SG    1 ? 
ATOM   2523 N  N     . LYS A 1 315 ? 28.297  -17.655 19.687  1.000 17.755  0 315 LYS A N     1 ? 
ATOM   2524 C  CA    . LYS A 1 315 ? 29.515  -16.905 19.327  1.000 19.170  0 315 LYS A CA    1 ? 
ATOM   2525 C  C     . LYS A 1 315 ? 29.526  -16.666 17.818  1.000 18.499  0 315 LYS A C     1 ? 
ATOM   2526 O  O     . LYS A 1 315 ? 29.828  -15.538 17.413  1.000 19.475  0 315 LYS A O     1 ? 
ATOM   2527 C  CB    . LYS A 1 315 ? 30.759  -17.662 19.795  1.000 21.958  0 315 LYS A CB    1 ? 
ATOM   2528 C  CG    . LYS A 1 315 ? 32.052  -16.885 19.586  1.000 24.808  0 315 LYS A CG    1 ? 
ATOM   2529 C  CD    . LYS A 1 315 ? 33.304  -17.625 19.961  1.000 28.799  0 315 LYS A CD    1 ? 
ATOM   2530 C  CE    . LYS A 1 315 ? 34.548  -16.918 19.436  1.000 31.191  0 315 LYS A CE    1 ? 
ATOM   2531 N  NZ    . LYS A 1 315 ? 35.670  -17.003 20.400  1.000 34.769  0 315 LYS A NZ    1 ? 
ATOM   2532 N  N     . ALA A 1 316 ? 29.248  -17.703 17.023  1.000 18.100  0 316 ALA A N     1 ? 
ATOM   2533 C  CA    . ALA A 1 316 ? 29.202  -17.657 15.540  1.000 16.920  0 316 ALA A CA    1 ? 
ATOM   2534 C  C     . ALA A 1 316 ? 28.190  -16.608 15.062  1.000 16.772  0 316 ALA A C     1 ? 
ATOM   2535 O  O     . ALA A 1 316 ? 28.444  -15.934 14.029  1.000 15.608  0 316 ALA A O     1 ? 
ATOM   2536 C  CB    . ALA A 1 316 ? 28.853  -19.021 15.003  1.000 16.759  0 316 ALA A CB    1 ? 
ATOM   2537 N  N     . LEU A 1 317 ? 27.040  -16.512 15.724  1.000 15.317  0 317 LEU A N     1 ? 
ATOM   2538 C  CA    . LEU A 1 317 ? 26.006  -15.492 15.384  1.000 14.969  0 317 LEU A CA    1 ? 
ATOM   2539 C  C     . LEU A 1 317 ? 26.436  -14.086 15.868  1.000 14.512  0 317 LEU A C     1 ? 
ATOM   2540 O  O     . LEU A 1 317 ? 26.188  -13.102 15.181  1.000 13.714  0 317 LEU A O     1 ? 
ATOM   2541 C  CB    . LEU A 1 317 ? 24.690  -15.955 16.008  1.000 14.038  0 317 LEU A CB    1 ? 
ATOM   2542 C  CG    . LEU A 1 317 ? 24.209  -17.300 15.483  1.000 14.725  0 317 LEU A CG    1 ? 
ATOM   2543 C  CD1   . LEU A 1 317 ? 23.016  -17.792 16.281  1.000 16.029  0 317 LEU A CD1   1 ? 
ATOM   2544 C  CD2   . LEU A 1 317 ? 23.891  -17.215 13.990  1.000 13.940  0 317 LEU A CD2   1 ? 
ATOM   2545 N  N     . ALA A 1 318 ? 26.992  -13.980 17.055  1.000 14.606  0 318 ALA A N     1 ? 
ATOM   2546 C  CA    . ALA A 1 318 ? 27.428  -12.687 17.627  1.000 16.305  0 318 ALA A CA    1 ? 
ATOM   2547 C  C     . ALA A 1 318 ? 28.555  -12.126 16.760  1.000 14.308  0 318 ALA A C     1 ? 
ATOM   2548 O  O     . ALA A 1 318 ? 28.724  -10.921 16.717  1.000 14.413  0 318 ALA A O     1 ? 
ATOM   2549 C  CB    . ALA A 1 318 ? 27.880  -12.874 19.052  1.000 16.577  0 318 ALA A CB    1 ? 
ATOM   2550 N  N     . ASP A 1 319 ? 29.300  -12.968 16.057  1.000 15.754  0 319 ASP A N     1 ? 
ATOM   2551 C  CA    . ASP A 1 319 ? 30.348  -12.454 15.120  1.000 15.648  0 319 ASP A CA    1 ? 
ATOM   2552 C  C     . ASP A 1 319 ? 29.685  -11.560 14.049  1.000 15.441  0 319 ASP A C     1 ? 
ATOM   2553 O  O     . ASP A 1 319 ? 30.419  -10.702 13.416  1.000 14.147  0 319 ASP A O     1 ? 
ATOM   2554 C  CB    . ASP A 1 319 ? 31.116  -13.599 14.446  1.000 15.497  0 319 ASP A CB    1 ? 
ATOM   2555 C  CG    . ASP A 1 319 ? 32.048  -14.346 15.387  1.000 15.357  0 319 ASP A CG    1 ? 
ATOM   2556 O  OD1   . ASP A 1 319 ? 32.357  -15.500 15.087  1.000 16.714  0 319 ASP A OD1   1 ? 
ATOM   2557 O  OD2   . ASP A 1 319 ? 32.460  -13.763 16.391  1.000 14.464  0 319 ASP A OD2   1 ? 
ATOM   2558 N  N     . HIS A 1 320 ? 28.384  -11.768 13.792  1.000 14.212  0 320 HIS A N     1 ? 
ATOM   2559 C  CA    . HIS A 1 320 ? 27.615  -11.092 12.701  1.000 13.638  0 320 HIS A CA    1 ? 
ATOM   2560 C  C     . HIS A 1 320 ? 26.641  -10.065 13.265  1.000 13.198  0 320 HIS A C     1 ? 
ATOM   2561 O  O     . HIS A 1 320 ? 26.471  -9.033  12.618  1.000 12.071  0 320 HIS A O     1 ? 
ATOM   2562 C  CB    . HIS A 1 320 ? 26.951  -12.132 11.784  1.000 14.521  0 320 HIS A CB    1 ? 
ATOM   2563 C  CG    . HIS A 1 320 ? 27.997  -12.950 11.128  1.000 14.108  0 320 HIS A CG    1 ? 
ATOM   2564 N  ND1   . HIS A 1 320 ? 28.656  -12.505 10.000  1.000 14.597  0 320 HIS A ND1   1 ? 
ATOM   2565 C  CD2   . HIS A 1 320 ? 28.662  -14.043 11.560  1.000 13.721  0 320 HIS A CD2   1 ? 
ATOM   2566 C  CE1   . HIS A 1 320 ? 29.666  -13.323 9.742   1.000 14.712  0 320 HIS A CE1   1 ? 
ATOM   2567 N  NE2   . HIS A 1 320 ? 29.664  -14.303 10.665  1.000 13.870  0 320 HIS A NE2   1 ? 
ATOM   2568 N  N     . PHE A 1 321 ? 26.063  -10.317 14.452  1.000 14.542  0 321 PHE A N     1 ? 
ATOM   2569 C  CA    . PHE A 1 321 ? 24.912  -9.556  15.017  1.000 14.851  0 321 PHE A CA    1 ? 
ATOM   2570 C  C     . PHE A 1 321 ? 25.411  -8.559  16.058  1.000 15.000  0 321 PHE A C     1 ? 
ATOM   2571 O  O     . PHE A 1 321 ? 24.660  -7.605  16.383  1.000 14.301  0 321 PHE A O     1 ? 
ATOM   2572 C  CB    . PHE A 1 321 ? 23.865  -10.526 15.586  1.000 15.325  0 321 PHE A CB    1 ? 
ATOM   2573 C  CG    . PHE A 1 321 ? 22.993  -11.132 14.518  1.000 16.206  0 321 PHE A CG    1 ? 
ATOM   2574 C  CD1   . PHE A 1 321 ? 22.270  -10.322 13.654  1.000 17.228  0 321 PHE A CD1   1 ? 
ATOM   2575 C  CD2   . PHE A 1 321 ? 22.923  -12.500 14.349  1.000 17.233  0 321 PHE A CD2   1 ? 
ATOM   2576 C  CE1   . PHE A 1 321 ? 21.496  -10.872 12.654  1.000 18.014  0 321 PHE A CE1   1 ? 
ATOM   2577 C  CE2   . PHE A 1 321 ? 22.134  -13.059 13.357  1.000 19.491  0 321 PHE A CE2   1 ? 
ATOM   2578 C  CZ    . PHE A 1 321 ? 21.437  -12.242 12.495  1.000 19.940  0 321 PHE A CZ    1 ? 
ATOM   2579 N  N     . GLY A 1 322 ? 26.644  -8.754  16.542  1.000 15.524  0 322 GLY A N     1 ? 
ATOM   2580 C  CA    . GLY A 1 322 ? 27.317  -7.834  17.480  1.000 16.312  0 322 GLY A CA    1 ? 
ATOM   2581 C  C     . GLY A 1 322 ? 27.200  -8.245  18.938  1.000 16.048  0 322 GLY A C     1 ? 
ATOM   2582 O  O     . GLY A 1 322 ? 26.631  -9.293  19.231  1.000 15.165  0 322 GLY A O     1 ? 
ATOM   2583 N  N     . SER A 1 323 ? 27.699  -7.410  19.846  1.000 19.313  0 323 SER A N     1 ? 
ATOM   2584 C  CA    . SER A 1 323 ? 27.908  -7.751  21.288  1.000 20.602  0 323 SER A CA    1 ? 
ATOM   2585 C  C     . SER A 1 323 ? 26.588  -7.879  22.080  1.000 19.824  0 323 SER A C     1 ? 
ATOM   2586 O  O     . SER A 1 323 ? 26.647  -8.291  23.273  1.000 18.718  0 323 SER A O     1 ? 
ATOM   2587 C  CB    . SER A 1 323 ? 28.837  -6.747  21.940  1.000 23.066  0 323 SER A CB    1 ? 
ATOM   2588 O  OG    . SER A 1 323 ? 28.398  -5.428  21.660  1.000 27.755  0 323 SER A OG    1 ? 
ATOM   2589 N  N     . GLU A 1 324 ? 25.428  -7.580  21.499  1.000 17.487  0 324 GLU A N     1 ? 
ATOM   2590 C  CA    . GLU A 1 324 ? 24.145  -7.752  22.226  1.000 16.777  0 324 GLU A CA    1 ? 
ATOM   2591 C  C     . GLU A 1 324 ? 23.538  -9.129  21.932  1.000 16.432  0 324 GLU A C     1 ? 
ATOM   2592 O  O     . GLU A 1 324 ? 22.560  -9.484  22.574  1.000 14.361  0 324 GLU A O     1 ? 
ATOM   2593 C  CB    . GLU A 1 324 ? 23.185  -6.609  21.903  1.000 16.966  0 324 GLU A CB    1 ? 
ATOM   2594 C  CG    . GLU A 1 324 ? 23.692  -5.269  22.390  1.000 17.389  0 324 GLU A CG    1 ? 
ATOM   2595 C  CD    . GLU A 1 324 ? 22.682  -4.164  22.598  1.000 18.679  0 324 GLU A CD    1 ? 
ATOM   2596 O  OE1   . GLU A 1 324 ? 21.800  -3.937  21.713  1.000 17.794  0 324 GLU A OE1   1 ? 
ATOM   2597 O  OE2   . GLU A 1 324 ? 22.778  -3.494  23.665  1.000 20.131  0 324 GLU A OE2   1 ? 
ATOM   2598 N  N     . PHE A 1 325 ? 24.049  -9.874  20.957  1.000 15.606  0 325 PHE A N     1 ? 
ATOM   2599 C  CA    . PHE A 1 325 ? 23.622  -11.263 20.790  1.000 16.149  0 325 PHE A CA    1 ? 
ATOM   2600 C  C     . PHE A 1 325 ? 24.164  -12.027 21.990  1.000 16.818  0 325 PHE A C     1 ? 
ATOM   2601 O  O     . PHE A 1 325 ? 25.363  -11.997 22.234  1.000 17.750  0 325 PHE A O     1 ? 
ATOM   2602 C  CB    . PHE A 1 325 ? 24.095  -11.887 19.484  1.000 15.955  0 325 PHE A CB    1 ? 
ATOM   2603 C  CG    . PHE A 1 325 ? 23.294  -13.122 19.169  1.000 15.916  0 325 PHE A CG    1 ? 
ATOM   2604 C  CD1   . PHE A 1 325 ? 23.596  -14.334 19.758  1.000 15.511  0 325 PHE A CD1   1 ? 
ATOM   2605 C  CD2   . PHE A 1 325 ? 22.148  -13.030 18.401  1.000 14.728  0 325 PHE A CD2   1 ? 
ATOM   2606 C  CE1   . PHE A 1 325 ? 22.831  -15.459 19.485  1.000 18.188  0 325 PHE A CE1   1 ? 
ATOM   2607 C  CE2   . PHE A 1 325 ? 21.383  -14.154 18.142  1.000 16.283  0 325 PHE A CE2   1 ? 
ATOM   2608 C  CZ    . PHE A 1 325 ? 21.747  -15.375 18.653  1.000 16.029  0 325 PHE A CZ    1 ? 
ATOM   2609 N  N     . PRO A 1 326 ? 23.302  -12.681 22.796  1.000 15.357  0 326 PRO A N     1 ? 
ATOM   2610 C  CA    . PRO A 1 326 ? 23.749  -13.333 24.023  1.000 16.411  0 326 PRO A CA    1 ? 
ATOM   2611 C  C     . PRO A 1 326 ? 24.579  -14.584 23.729  1.000 17.753  0 326 PRO A C     1 ? 
ATOM   2612 O  O     . PRO A 1 326 ? 24.292  -15.368 22.745  1.000 17.955  0 326 PRO A O     1 ? 
ATOM   2613 C  CB    . PRO A 1 326 ? 22.457  -13.618 24.786  1.000 15.885  0 326 PRO A CB    1 ? 
ATOM   2614 C  CG    . PRO A 1 326 ? 21.438  -13.723 23.724  1.000 16.571  0 326 PRO A CG    1 ? 
ATOM   2615 C  CD    . PRO A 1 326 ? 21.866  -12.793 22.605  1.000 16.056  0 326 PRO A CD    1 ? 
ATOM   2616 N  N     . VAL A 1 327 ? 25.696  -14.664 24.454  1.000 16.971  0 327 VAL A N     1 ? 
ATOM   2617 C  CA    . VAL A 1 327 ? 26.649  -15.794 24.374  1.000 19.439  0 327 VAL A CA    1 ? 
ATOM   2618 C  C     . VAL A 1 327 ? 26.771  -16.380 25.785  1.000 21.733  0 327 VAL A C     1 ? 
ATOM   2619 O  O     . VAL A 1 327 ? 27.384  -15.756 26.659  1.000 22.931  0 327 VAL A O     1 ? 
ATOM   2620 C  CB    . VAL A 1 327 ? 28.006  -15.353 23.782  1.000 18.497  0 327 VAL A CB    1 ? 
ATOM   2621 C  CG1   . VAL A 1 327 ? 28.956  -16.528 23.653  1.000 18.726  0 327 VAL A CG1   1 ? 
ATOM   2622 C  CG2   . VAL A 1 327 ? 27.847  -14.664 22.432  1.000 17.249  0 327 VAL A CG2   1 ? 
ATOM   2623 N  N     . PRO A 1 328 ? 26.125  -17.539 26.062  1.000 27.198  0 328 PRO A N     1 ? 
ATOM   2624 C  CA    . PRO A 1 328 ? 26.266  -18.226 27.351  1.000 28.725  0 328 PRO A CA    1 ? 
ATOM   2625 C  C     . PRO A 1 328 ? 27.669  -18.841 27.490  1.000 31.197  0 328 PRO A C     1 ? 
ATOM   2626 O  O     . PRO A 1 328 ? 28.211  -19.259 26.501  1.000 27.798  0 328 PRO A O     1 ? 
ATOM   2627 C  CB    . PRO A 1 328 ? 25.203  -19.340 27.316  1.000 29.496  0 328 PRO A CB    1 ? 
ATOM   2628 C  CG    . PRO A 1 328 ? 24.340  -19.046 26.096  1.000 30.092  0 328 PRO A CG    1 ? 
ATOM   2629 C  CD    . PRO A 1 328 ? 25.213  -18.252 25.152  1.000 28.438  0 328 PRO A CD    1 ? 
ATOM   2630 N  N     . GLU A 1 329 ? 28.229  -18.887 28.700  1.000 36.652  0 329 GLU A N     1 ? 
ATOM   2631 C  CA    . GLU A 1 329 ? 29.545  -19.549 28.950  1.000 42.717  0 329 GLU A CA    1 ? 
ATOM   2632 C  C     . GLU A 1 329 ? 29.473  -21.052 28.604  1.000 42.893  0 329 GLU A C     1 ? 
ATOM   2633 O  O     . GLU A 1 329 ? 28.382  -21.659 28.757  1.000 39.409  0 329 GLU A O     1 ? 
ATOM   2634 C  CB    . GLU A 1 329 ? 29.958  -19.351 30.408  1.000 46.862  0 329 GLU A CB    1 ? 
ATOM   2635 C  CG    . GLU A 1 329 ? 31.437  -19.588 30.635  1.000 51.980  0 329 GLU A CG    1 ? 
ATOM   2636 C  CD    . GLU A 1 329 ? 31.863  -19.583 32.093  1.000 59.294  0 329 GLU A CD    1 ? 
ATOM   2637 O  OE1   . GLU A 1 329 ? 30.982  -19.382 32.976  1.000 61.352  0 329 GLU A OE1   1 ? 
ATOM   2638 O  OE2   . GLU A 1 329 ? 33.074  -19.794 32.347  1.000 60.202  0 329 GLU A OE2   1 ? 
ATOM   2639 N  N     . LYS A 1 330 ? 30.595  -21.645 28.172  1.000 49.492  0 330 LYS A N     1 ? 
ATOM   2640 C  CA    . LYS A 1 330 ? 30.729  -23.118 27.939  1.000 52.518  0 330 LYS A CA    1 ? 
ATOM   2641 C  C     . LYS A 1 330 ? 31.006  -23.820 29.274  1.000 48.367  0 330 LYS A C     1 ? 
ATOM   2642 O  O     . LYS A 1 330 ? 31.514  -23.216 30.208  1.000 39.935  0 330 LYS A O     1 ? 
ATOM   2643 C  CB    . LYS A 1 330 ? 31.831  -23.423 26.915  1.000 62.591  0 330 LYS A CB    1 ? 
ATOM   2644 C  CG    . LYS A 1 330 ? 32.328  -24.868 26.908  1.000 68.274  0 330 LYS A CG    1 ? 
ATOM   2645 C  CD    . LYS A 1 330 ? 33.209  -25.221 25.722  1.000 67.741  0 330 LYS A CD    1 ? 
ATOM   2646 C  CE    . LYS A 1 330 ? 33.934  -26.536 25.911  1.000 69.067  0 330 LYS A CE    1 ? 
ATOM   2647 N  NZ    . LYS A 1 330 ? 34.948  -26.764 24.854  1.000 71.848  0 330 LYS A NZ    1 ? 
HETATM 2648 N  N1    . CTP B 2 .   ? 10.909  5.299   1.369   1.000 47.297  0 401 CTP A N1    1 ? 
HETATM 2649 C  C2    . CTP B 2 .   ? 10.649  4.912   0.040   1.000 47.615  0 401 CTP A C2    1 ? 
HETATM 2650 N  N3    . CTP B 2 .   ? 11.691  4.671   -0.801  1.000 42.752  0 401 CTP A N3    1 ? 
HETATM 2651 C  C4    . CTP B 2 .   ? 12.952  4.820   -0.379  1.000 44.286  0 401 CTP A C4    1 ? 
HETATM 2652 C  C5    . CTP B 2 .   ? 13.241  5.229   0.956   1.000 45.188  0 401 CTP A C5    1 ? 
HETATM 2653 C  C6    . CTP B 2 .   ? 12.206  5.455   1.785   1.000 46.056  0 401 CTP A C6    1 ? 
HETATM 2654 O  O2    . CTP B 2 .   ? 9.472   4.775   -0.329  1.000 48.700  0 401 CTP A O2    1 ? 
HETATM 2655 N  N4    . CTP B 2 .   ? 13.927  4.569   -1.245  1.000 47.214  0 401 CTP A N4    1 ? 
HETATM 2656 C  "C1'" . CTP B 2 .   ? 9.757   5.544   2.297   1.000 45.739  0 401 CTP A "C1'" 1 ? 
HETATM 2657 C  "C2'" . CTP B 2 .   ? 9.168   4.247   2.885   1.000 49.020  0 401 CTP A "C2'" 1 ? 
HETATM 2658 O  "O2'" . CTP B 2 .   ? 7.789   4.354   3.183   1.000 42.463  0 401 CTP A "O2'" 1 ? 
HETATM 2659 C  "C3'" . CTP B 2 .   ? 10.017  4.109   4.161   1.000 48.740  0 401 CTP A "C3'" 1 ? 
HETATM 2660 C  "C4'" . CTP B 2 .   ? 10.086  5.569   4.634   1.000 49.421  0 401 CTP A "C4'" 1 ? 
HETATM 2661 O  "O4'" . CTP B 2 .   ? 10.196  6.329   3.394   1.000 46.450  0 401 CTP A "O4'" 1 ? 
HETATM 2662 O  "O3'" . CTP B 2 .   ? 9.454   3.275   5.164   1.000 47.112  0 401 CTP A "O3'" 1 ? 
HETATM 2663 C  "C5'" . CTP B 2 .   ? 11.231  5.904   5.561   1.000 47.294  0 401 CTP A "C5'" 1 ? 
HETATM 2664 O  "O5'" . CTP B 2 .   ? 12.476  5.422   4.973   1.000 47.067  0 401 CTP A "O5'" 1 ? 
HETATM 2665 P  PA    . CTP B 2 .   ? 13.727  4.979   5.889   1.000 52.192  0 401 CTP A PA    1 ? 
HETATM 2666 O  O1A   . CTP B 2 .   ? 14.935  4.853   5.008   1.000 46.009  0 401 CTP A O1A   1 ? 
HETATM 2667 O  O2A   . CTP B 2 .   ? 13.788  5.854   7.118   1.000 38.620  0 401 CTP A O2A   1 ? 
HETATM 2668 O  O3A   . CTP B 2 .   ? 13.309  3.455   6.266   1.000 45.842  0 401 CTP A O3A   1 ? 
HETATM 2669 P  PB    . CTP B 2 .   ? 12.627  2.599   7.449   1.000 33.790  0 401 CTP A PB    1 ? 
HETATM 2670 O  O1B   . CTP B 2 .   ? 11.667  1.635   6.800   1.000 39.170  0 401 CTP A O1B   1 ? 
HETATM 2671 O  O2B   . CTP B 2 .   ? 12.152  3.528   8.520   1.000 32.835  0 401 CTP A O2B   1 ? 
HETATM 2672 O  O3B   . CTP B 2 .   ? 13.892  1.782   8.011   1.000 33.996  0 401 CTP A O3B   1 ? 
HETATM 2673 P  PG    . CTP B 2 .   ? 14.964  2.061   9.181   1.000 30.438  0 401 CTP A PG    1 ? 
HETATM 2674 O  O1G   . CTP B 2 .   ? 14.374  1.514   10.454  1.000 33.305  0 401 CTP A O1G   1 ? 
HETATM 2675 O  O2G   . CTP B 2 .   ? 15.095  3.591   9.197   1.000 36.180  0 401 CTP A O2G   1 ? 
HETATM 2676 O  O3G   . CTP B 2 .   ? 16.283  1.342   8.817   1.000 29.829  0 401 CTP A O3G   1 ? 
HETATM 2677 N  N1    . CTP C 2 .   ? 12.435  9.351   2.330   1.000 94.010  0 402 CTP A N1    1 ? 
HETATM 2678 C  C2    . CTP C 2 .   ? 11.037  9.342   2.426   1.000 89.025  0 402 CTP A C2    1 ? 
HETATM 2679 N  N3    . CTP C 2 .   ? 10.303  8.952   1.348   1.000 88.259  0 402 CTP A N3    1 ? 
HETATM 2680 C  C4    . CTP C 2 .   ? 10.905  8.595   0.200   1.000 89.319  0 402 CTP A C4    1 ? 
HETATM 2681 C  C5    . CTP C 2 .   ? 12.321  8.607   0.081   1.000 90.331  0 402 CTP A C5    1 ? 
HETATM 2682 C  C6    . CTP C 2 .   ? 13.035  8.986   1.153   1.000 94.961  0 402 CTP A C6    1 ? 
HETATM 2683 O  O2    . CTP C 2 .   ? 10.507  9.670   3.500   1.000 89.849  0 402 CTP A O2    1 ? 
HETATM 2684 N  N4    . CTP C 2 .   ? 10.145  8.229   -0.824  1.000 84.885  0 402 CTP A N4    1 ? 
HETATM 2685 C  "C1'" . CTP C 2 .   ? 13.248  9.778   3.511   1.000 96.305  0 402 CTP A "C1'" 1 ? 
HETATM 2686 C  "C2'" . CTP C 2 .   ? 13.353  8.708   4.609   1.000 90.559  0 402 CTP A "C2'" 1 ? 
HETATM 2687 O  "O2'" . CTP C 2 .   ? 13.130  9.262   5.892   1.000 71.267  0 402 CTP A "O2'" 1 ? 
HETATM 2688 C  "C3'" . CTP C 2 .   ? 14.787  8.163   4.483   1.000 97.886  0 402 CTP A "C3'" 1 ? 
HETATM 2689 C  "C4'" . CTP C 2 .   ? 15.523  9.092   3.496   1.000 113.194 0 402 CTP A "C4'" 1 ? 
HETATM 2690 O  "O4'" . CTP C 2 .   ? 14.553  10.089  3.073   1.000 106.775 0 402 CTP A "O4'" 1 ? 
HETATM 2691 O  "O3'" . CTP C 2 .   ? 15.404  8.159   5.768   1.000 93.276  0 402 CTP A "O3'" 1 ? 
HETATM 2692 C  "C5'" . CTP C 2 .   ? 16.158  8.417   2.290   1.000 133.105 0 402 CTP A "C5'" 1 ? 
HETATM 2693 O  "O5'" . CTP C 2 .   ? 16.731  9.413   1.354   1.000 166.937 0 402 CTP A "O5'" 1 ? 
HETATM 2694 P  PA    . CTP C 2 .   ? 17.454  8.991   -0.041  1.000 186.997 0 402 CTP A PA    1 ? 
HETATM 2695 O  O1A   . CTP C 2 .   ? 18.106  7.655   0.127   1.000 188.112 0 402 CTP A O1A   1 ? 
HETATM 2696 O  O2A   . CTP C 2 .   ? 16.476  9.135   -1.163  1.000 182.213 0 402 CTP A O2A   1 ? 
HETATM 2697 O  O3A   . CTP C 2 .   ? 18.616  10.111  -0.236  1.000 193.656 0 402 CTP A O3A   1 ? 
HETATM 2698 P  PB    . CTP C 2 .   ? 19.675  10.570  -1.369  1.000 187.814 0 402 CTP A PB    1 ? 
HETATM 2699 O  O1B   . CTP C 2 .   ? 19.038  10.418  -2.711  1.000 181.104 0 402 CTP A O1B   1 ? 
HETATM 2700 O  O2B   . CTP C 2 .   ? 21.001  9.923   -1.123  1.000 191.730 0 402 CTP A O2B   1 ? 
HETATM 2701 O  O3B   . CTP C 2 .   ? 19.831  12.139  -1.058  1.000 174.210 0 402 CTP A O3B   1 ? 
HETATM 2702 P  PG    . CTP C 2 .   ? 21.055  13.117  -0.620  1.000 156.288 0 402 CTP A PG    1 ? 
HETATM 2703 O  O1G   . CTP C 2 .   ? 20.464  14.504  -0.507  1.000 144.328 0 402 CTP A O1G   1 ? 
HETATM 2704 O  O2G   . CTP C 2 .   ? 21.574  12.614  0.703   1.000 151.054 0 402 CTP A O2G   1 ? 
HETATM 2705 O  O3G   . CTP C 2 .   ? 22.077  12.994  -1.728  1.000 151.058 0 402 CTP A O3G   1 ? 
HETATM 2706 MG MG    . MG  D 3 .   ? 13.417  4.943   9.136   1.000 29.563  0 403 MG  A MG    1 ? 
HETATM 2707 MG MG    . MG  E 3 .   ? 14.687  8.110   7.749   1.000 17.374  0 404 MG  A MG    1 ? 
HETATM 2708 O  O     . HOH F 4 .   ? 24.764  -12.278 5.585   1.000 31.748  0 501 HOH A O     1 ? 
HETATM 2709 O  O     . HOH F 4 .   ? -5.516  -2.625  2.745   1.000 25.907  0 502 HOH A O     1 ? 
HETATM 2710 O  O     . HOH F 4 .   ? 5.538   28.746  -4.665  1.000 36.368  0 503 HOH A O     1 ? 
HETATM 2711 O  O     . HOH F 4 .   ? 0.969   6.747   8.877   1.000 37.489  0 504 HOH A O     1 ? 
HETATM 2712 O  O     . HOH F 4 .   ? 11.853  40.411  6.520   1.000 32.184  0 505 HOH A O     1 ? 
HETATM 2713 O  O     . HOH F 4 .   ? -3.575  25.869  3.244   1.000 30.570  0 506 HOH A O     1 ? 
HETATM 2714 O  O     . HOH F 4 .   ? -2.019  -15.378 12.907  1.000 35.189  0 507 HOH A O     1 ? 
HETATM 2715 O  O     . HOH F 4 .   ? 20.875  -1.364  15.409  1.000 20.031  0 508 HOH A O     1 ? 
HETATM 2716 O  O     . HOH F 4 .   ? -2.208  4.472   -0.224  1.000 34.635  0 509 HOH A O     1 ? 
HETATM 2717 O  O     . HOH F 4 .   ? 20.012  -2.349  21.384  1.000 13.226  0 510 HOH A O     1 ? 
HETATM 2718 O  O     . HOH F 4 .   ? -1.521  20.767  -8.854  1.000 34.518  0 511 HOH A O     1 ? 
HETATM 2719 O  O     . HOH F 4 .   ? 27.757  -2.636  0.859   1.000 13.420  0 512 HOH A O     1 ? 
HETATM 2720 O  O     . HOH F 4 .   ? 28.780  1.810   18.373  1.000 37.658  0 513 HOH A O     1 ? 
HETATM 2721 O  O     . HOH F 4 .   ? 8.305   22.423  19.466  1.000 31.678  0 514 HOH A O     1 ? 
HETATM 2722 O  O     . HOH F 4 .   ? 19.369  4.462   22.702  1.000 39.985  0 515 HOH A O     1 ? 
HETATM 2723 O  O     . HOH F 4 .   ? 12.754  4.982   11.265  1.000 25.789  0 516 HOH A O     1 ? 
HETATM 2724 O  O     . HOH F 4 .   ? -1.750  1.297   -2.038  1.000 24.621  0 517 HOH A O     1 ? 
HETATM 2725 O  O     . HOH F 4 .   ? 16.366  2.927   5.651   1.000 38.191  0 518 HOH A O     1 ? 
HETATM 2726 O  O     . HOH F 4 .   ? 16.833  -8.584  28.608  1.000 26.757  0 519 HOH A O     1 ? 
HETATM 2727 O  O     . HOH F 4 .   ? 12.368  -17.442 5.560   1.000 18.993  0 520 HOH A O     1 ? 
HETATM 2728 O  O     . HOH F 4 .   ? 6.556   -1.740  19.216  1.000 18.137  0 521 HOH A O     1 ? 
HETATM 2729 O  O     . HOH F 4 .   ? 20.120  -2.562  -7.297  1.000 28.866  0 522 HOH A O     1 ? 
HETATM 2730 O  O     . HOH F 4 .   ? 10.579  -16.656 -0.355  1.000 21.047  0 523 HOH A O     1 ? 
HETATM 2731 O  O     . HOH F 4 .   ? 7.230   -14.033 0.828   1.000 14.727  0 524 HOH A O     1 ? 
HETATM 2732 O  O     . HOH F 4 .   ? 30.559  -26.795 19.590  1.000 22.549  0 525 HOH A O     1 ? 
HETATM 2733 O  O     . HOH F 4 .   ? 29.289  -10.210 -10.922 1.000 31.096  0 526 HOH A O     1 ? 
HETATM 2734 O  O     . HOH F 4 .   ? 14.587  -15.385 25.397  1.000 26.034  0 527 HOH A O     1 ? 
HETATM 2735 O  O     . HOH F 4 .   ? 19.766  20.321  -0.549  1.000 31.537  0 528 HOH A O     1 ? 
HETATM 2736 O  O     . HOH F 4 .   ? 6.461   4.978   5.243   1.000 21.210  0 529 HOH A O     1 ? 
HETATM 2737 O  O     . HOH F 4 .   ? 7.066   4.322   0.319   1.000 37.717  0 530 HOH A O     1 ? 
HETATM 2738 O  O     . HOH F 4 .   ? 28.146  -10.882 7.635   1.000 15.890  0 531 HOH A O     1 ? 
HETATM 2739 O  O     . HOH F 4 .   ? -2.569  29.938  16.352  1.000 49.968  0 532 HOH A O     1 ? 
HETATM 2740 O  O     . HOH F 4 .   ? 16.463  3.194   14.647  1.000 28.470  0 533 HOH A O     1 ? 
HETATM 2741 O  O     . HOH F 4 .   ? 6.825   17.388  22.576  1.000 38.967  0 534 HOH A O     1 ? 
HETATM 2742 O  O     . HOH F 4 .   ? 28.708  -0.014  23.704  1.000 41.617  0 535 HOH A O     1 ? 
HETATM 2743 O  O     . HOH F 4 .   ? 28.274  -22.710 7.175   1.000 41.066  0 536 HOH A O     1 ? 
HETATM 2744 O  O     . HOH F 4 .   ? 22.000  -15.570 -8.753  1.000 28.755  0 537 HOH A O     1 ? 
HETATM 2745 O  O     . HOH F 4 .   ? 32.892  -10.119 13.709  1.000 15.103  0 538 HOH A O     1 ? 
HETATM 2746 O  O     . HOH F 4 .   ? 1.046   2.339   9.713   1.000 37.651  0 539 HOH A O     1 ? 
HETATM 2747 O  O     . HOH F 4 .   ? 12.380  17.042  18.751  1.000 35.024  0 540 HOH A O     1 ? 
HETATM 2748 O  O     . HOH F 4 .   ? 26.698  -2.499  -21.281 1.000 15.046  0 541 HOH A O     1 ? 
HETATM 2749 O  O     . HOH F 4 .   ? 12.732  -25.682 12.761  1.000 41.777  0 542 HOH A O     1 ? 
HETATM 2750 O  O     . HOH F 4 .   ? 11.598  -11.548 21.224  1.000 19.588  0 543 HOH A O     1 ? 
HETATM 2751 O  O     . HOH F 4 .   ? 11.650  -0.940  8.000   1.000 22.134  0 544 HOH A O     1 ? 
HETATM 2752 O  O     . HOH F 4 .   ? 11.164  20.320  -12.687 1.000 33.183  0 545 HOH A O     1 ? 
HETATM 2753 O  O     . HOH F 4 .   ? 12.437  -13.056 24.598  1.000 30.443  0 546 HOH A O     1 ? 
HETATM 2754 O  O     . HOH F 4 .   ? 23.886  -11.988 27.642  1.000 29.542  0 547 HOH A O     1 ? 
HETATM 2755 O  O     . HOH F 4 .   ? 15.032  1.328   12.973  1.000 20.343  0 548 HOH A O     1 ? 
HETATM 2756 O  O     . HOH F 4 .   ? -2.976  19.253  4.221   1.000 33.447  0 549 HOH A O     1 ? 
HETATM 2757 O  O     . HOH F 4 .   ? -1.419  -13.145 5.431   1.000 24.683  0 550 HOH A O     1 ? 
HETATM 2758 O  O     . HOH F 4 .   ? 1.065   -7.322  11.252  1.000 27.274  0 551 HOH A O     1 ? 
HETATM 2759 O  O     . HOH F 4 .   ? 30.718  -16.812 8.203   1.000 22.040  0 552 HOH A O     1 ? 
HETATM 2760 O  O     . HOH F 4 .   ? 14.724  -2.961  23.584  1.000 17.133  0 553 HOH A O     1 ? 
HETATM 2761 O  O     . HOH F 4 .   ? 5.861   -27.739 17.625  1.000 28.095  0 554 HOH A O     1 ? 
HETATM 2762 O  O     . HOH F 4 .   ? 0.241   -21.222 9.387   1.000 40.102  0 555 HOH A O     1 ? 
HETATM 2763 O  O     . HOH F 4 .   ? 23.688  12.889  17.542  1.000 41.062  0 556 HOH A O     1 ? 
HETATM 2764 O  O     . HOH F 4 .   ? 3.267   -25.501 11.287  1.000 29.659  0 557 HOH A O     1 ? 
HETATM 2765 O  O     . HOH F 4 .   ? 18.260  -24.752 8.858   1.000 19.737  0 558 HOH A O     1 ? 
HETATM 2766 O  O     . HOH F 4 .   ? 28.045  -10.206 -16.476 1.000 22.435  0 559 HOH A O     1 ? 
HETATM 2767 O  O     . HOH F 4 .   ? 26.219  -22.736 27.683  1.000 44.522  0 560 HOH A O     1 ? 
HETATM 2768 O  O     . HOH F 4 .   ? 9.974   5.973   11.388  1.000 30.590  0 561 HOH A O     1 ? 
HETATM 2769 O  O     . HOH F 4 .   ? 0.972   2.327   -4.933  1.000 22.935  0 562 HOH A O     1 ? 
HETATM 2770 O  O     . HOH F 4 .   ? 4.057   -3.859  10.263  1.000 20.186  0 563 HOH A O     1 ? 
HETATM 2771 O  O     . HOH F 4 .   ? 7.022   -3.769  -7.786  1.000 24.830  0 564 HOH A O     1 ? 
HETATM 2772 O  O     . HOH F 4 .   ? 7.248   40.416  2.296   1.000 26.490  0 565 HOH A O     1 ? 
HETATM 2773 O  O     . HOH F 4 .   ? 36.424  -6.707  -6.624  1.000 18.044  0 566 HOH A O     1 ? 
HETATM 2774 O  O     . HOH F 4 .   ? 25.526  -10.221 24.722  1.000 23.181  0 567 HOH A O     1 ? 
HETATM 2775 O  O     . HOH F 4 .   ? 7.428   -12.783 -3.819  1.000 30.404  0 568 HOH A O     1 ? 
HETATM 2776 O  O     . HOH F 4 .   ? 29.232  0.655   -9.734  1.000 30.670  0 569 HOH A O     1 ? 
HETATM 2777 O  O     . HOH F 4 .   ? 10.249  -24.662 14.911  1.000 32.068  0 570 HOH A O     1 ? 
HETATM 2778 O  O     . HOH F 4 .   ? 1.409   11.371  22.408  1.000 29.314  0 571 HOH A O     1 ? 
HETATM 2779 O  O     . HOH F 4 .   ? 27.889  -11.098 22.305  1.000 17.827  0 572 HOH A O     1 ? 
HETATM 2780 O  O     . HOH F 4 .   ? 3.254   -7.328  -4.462  1.000 26.378  0 573 HOH A O     1 ? 
HETATM 2781 O  O     . HOH F 4 .   ? 25.717  -12.435 -8.344  1.000 17.232  0 574 HOH A O     1 ? 
HETATM 2782 O  O     . HOH F 4 .   ? 9.997   -25.414 22.880  1.000 41.632  0 575 HOH A O     1 ? 
HETATM 2783 O  O     . HOH F 4 .   ? 1.005   -7.577  2.138   1.000 22.825  0 576 HOH A O     1 ? 
HETATM 2784 O  O     . HOH F 4 .   ? 24.494  -6.167  18.651  1.000 14.501  0 577 HOH A O     1 ? 
HETATM 2785 O  O     . HOH F 4 .   ? 17.859  -8.978  -8.511  1.000 22.306  0 578 HOH A O     1 ? 
HETATM 2786 O  O     . HOH F 4 .   ? 18.058  -0.834  -10.702 1.000 31.105  0 579 HOH A O     1 ? 
HETATM 2787 O  O     . HOH F 4 .   ? 9.291   -0.093  16.098  1.000 27.851  0 580 HOH A O     1 ? 
HETATM 2788 O  O     . HOH F 4 .   ? -1.980  -24.970 16.887  1.000 40.901  0 581 HOH A O     1 ? 
HETATM 2789 O  O     . HOH F 4 .   ? 6.125   5.200   -1.897  1.000 19.570  0 582 HOH A O     1 ? 
HETATM 2790 O  O     . HOH F 4 .   ? 3.128   -5.182  -5.600  1.000 28.676  0 583 HOH A O     1 ? 
HETATM 2791 O  O     . HOH F 4 .   ? 32.018  1.949   -4.753  1.000 24.408  0 584 HOH A O     1 ? 
HETATM 2792 O  O     . HOH F 4 .   ? 14.289  1.832   -10.290 1.000 27.081  0 585 HOH A O     1 ? 
HETATM 2793 O  O     . HOH F 4 .   ? 5.812   -15.151 3.831   1.000 27.178  0 586 HOH A O     1 ? 
HETATM 2794 O  O     . HOH F 4 .   ? 27.018  -1.883  -14.262 1.000 40.971  0 587 HOH A O     1 ? 
HETATM 2795 O  O     . HOH F 4 .   ? 21.996  0.949   -10.165 1.000 35.660  0 588 HOH A O     1 ? 
HETATM 2796 O  O     . HOH F 4 .   ? -0.581  7.409   -3.145  1.000 43.349  0 589 HOH A O     1 ? 
HETATM 2797 O  O     . HOH F 4 .   ? -3.983  -35.368 19.548  1.000 46.589  0 590 HOH A O     1 ? 
HETATM 2798 O  O     . HOH F 4 .   ? 3.753   15.465  -11.072 1.000 44.456  0 591 HOH A O     1 ? 
HETATM 2799 O  O     . HOH F 4 .   ? 32.991  -28.437 13.424  1.000 29.346  0 592 HOH A O     1 ? 
HETATM 2800 O  O     . HOH F 4 .   ? 10.817  5.297   -3.541  1.000 36.386  0 593 HOH A O     1 ? 
HETATM 2801 O  O     . HOH F 4 .   ? 0.528   31.253  1.126   1.000 37.835  0 594 HOH A O     1 ? 
HETATM 2802 O  O     . HOH F 4 .   ? 3.223   -1.625  8.904   1.000 22.518  0 595 HOH A O     1 ? 
HETATM 2803 O  O     . HOH F 4 .   ? 0.399   15.262  -3.974  1.000 23.978  0 596 HOH A O     1 ? 
HETATM 2804 O  O     . HOH F 4 .   ? 32.917  -11.479 7.010   1.000 28.329  0 597 HOH A O     1 ? 
HETATM 2805 O  O     . HOH F 4 .   ? 0.900   -14.032 20.505  1.000 48.721  0 598 HOH A O     1 ? 
HETATM 2806 O  O     . HOH F 4 .   ? 12.794  -17.012 2.931   1.000 24.491  0 599 HOH A O     1 ? 
HETATM 2807 O  O     . HOH F 4 .   ? 13.078  -23.450 17.484  1.000 22.772  0 600 HOH A O     1 ? 
HETATM 2808 O  O     . HOH F 4 .   ? -2.896  -4.909  8.206   1.000 25.417  0 601 HOH A O     1 ? 
HETATM 2809 O  O     . HOH F 4 .   ? 20.556  -3.178  -10.462 1.000 35.815  0 602 HOH A O     1 ? 
HETATM 2810 O  O     . HOH F 4 .   ? 30.566  -9.633  18.342  1.000 36.012  0 603 HOH A O     1 ? 
HETATM 2811 O  O     . HOH F 4 .   ? -0.040  8.634   11.290  1.000 38.276  0 604 HOH A O     1 ? 
HETATM 2812 O  O     . HOH F 4 .   ? 27.166  -3.707  -12.651 1.000 16.705  0 605 HOH A O     1 ? 
HETATM 2813 O  O     . HOH F 4 .   ? 26.149  -21.786 1.705   1.000 35.689  0 606 HOH A O     1 ? 
HETATM 2814 O  O     . HOH F 4 .   ? 10.500  -24.577 11.665  1.000 25.611  0 607 HOH A O     1 ? 
HETATM 2815 O  O     . HOH F 4 .   ? 11.501  0.777   23.111  1.000 28.690  0 608 HOH A O     1 ? 
HETATM 2816 O  O     . HOH F 4 .   ? 10.517  10.551  6.331   1.000 38.033  0 609 HOH A O     1 ? 
HETATM 2817 O  O     . HOH F 4 .   ? 29.156  1.371   -17.670 1.000 29.876  0 610 HOH A O     1 ? 
HETATM 2818 O  O     . HOH F 4 .   ? 29.462  -5.146  19.099  1.000 41.661  0 611 HOH A O     1 ? 
HETATM 2819 O  O     . HOH F 4 .   ? 5.621   -17.333 5.361   1.000 29.662  0 612 HOH A O     1 ? 
HETATM 2820 O  O     . HOH F 4 .   ? -3.057  2.967   19.384  1.000 39.810  0 613 HOH A O     1 ? 
HETATM 2821 O  O     . HOH F 4 .   ? 6.616   -15.664 16.450  1.000 9.762   0 614 HOH A O     1 ? 
HETATM 2822 O  O     . HOH F 4 .   ? 31.051  -2.250  14.215  1.000 26.049  0 615 HOH A O     1 ? 
HETATM 2823 O  O     . HOH F 4 .   ? 8.793   38.722  8.729   1.000 36.201  0 616 HOH A O     1 ? 
HETATM 2824 O  O     . HOH F 4 .   ? 18.421  -24.767 19.837  1.000 42.469  0 617 HOH A O     1 ? 
HETATM 2825 O  O     . HOH F 4 .   ? 10.407  15.408  0.642   1.000 23.201  0 618 HOH A O     1 ? 
HETATM 2826 O  O     . HOH F 4 .   ? -0.495  -15.985 16.292  1.000 27.873  0 619 HOH A O     1 ? 
HETATM 2827 O  O     . HOH F 4 .   ? 24.743  -18.477 -2.002  1.000 30.756  0 620 HOH A O     1 ? 
HETATM 2828 O  O     . HOH F 4 .   ? 9.774   2.776   16.552  1.000 31.218  0 621 HOH A O     1 ? 
HETATM 2829 O  O     . HOH F 4 .   ? 27.505  -0.547  -18.393 1.000 25.538  0 622 HOH A O     1 ? 
HETATM 2830 O  O     . HOH F 4 .   ? 23.430  2.413   15.135  1.000 22.682  0 623 HOH A O     1 ? 
HETATM 2831 O  O     . HOH F 4 .   ? 2.596   2.981   15.893  1.000 24.296  0 624 HOH A O     1 ? 
HETATM 2832 O  O     . HOH F 4 .   ? 5.536   4.925   26.082  1.000 33.810  0 625 HOH A O     1 ? 
HETATM 2833 O  O     . HOH F 4 .   ? 21.105  -6.635  -12.396 1.000 24.690  0 626 HOH A O     1 ? 
HETATM 2834 O  O     . HOH F 4 .   ? 16.619  -22.654 16.218  1.000 36.724  0 627 HOH A O     1 ? 
HETATM 2835 O  O     . HOH F 4 .   ? 24.037  -13.951 -12.215 1.000 28.678  0 628 HOH A O     1 ? 
HETATM 2836 O  O     . HOH F 4 .   ? 12.082  5.617   22.851  1.000 34.246  0 629 HOH A O     1 ? 
HETATM 2837 O  O     . HOH F 4 .   ? 7.839   -9.276  16.611  1.000 25.119  0 630 HOH A O     1 ? 
HETATM 2838 O  O     . HOH F 4 .   ? 0.363   6.752   1.006   1.000 19.926  0 631 HOH A O     1 ? 
HETATM 2839 O  O     . HOH F 4 .   ? 1.727   -9.580  14.810  1.000 19.262  0 632 HOH A O     1 ? 
HETATM 2840 O  O     . HOH F 4 .   ? 30.677  -16.490 12.323  1.000 27.371  0 633 HOH A O     1 ? 
HETATM 2841 O  O     . HOH F 4 .   ? 12.347  -13.401 -7.228  1.000 42.023  0 634 HOH A O     1 ? 
HETATM 2842 O  O     . HOH F 4 .   ? 17.984  0.832   25.562  1.000 22.263  0 635 HOH A O     1 ? 
HETATM 2843 O  O     . HOH F 4 .   ? -0.112  -24.340 14.142  1.000 38.222  0 636 HOH A O     1 ? 
HETATM 2844 O  O     . HOH F 4 .   ? 13.408  -16.014 -5.364  1.000 26.107  0 637 HOH A O     1 ? 
HETATM 2845 O  O     . HOH F 4 .   ? 33.720  -7.095  1.526   1.000 24.936  0 638 HOH A O     1 ? 
HETATM 2846 O  O     . HOH F 4 .   ? 16.180  -19.880 16.182  1.000 16.022  0 639 HOH A O     1 ? 
HETATM 2847 O  O     . HOH F 4 .   ? 4.266   -10.734 -0.017  1.000 20.618  0 640 HOH A O     1 ? 
HETATM 2848 O  O     . HOH F 4 .   ? 19.249  -24.134 15.436  1.000 26.675  0 641 HOH A O     1 ? 
HETATM 2849 O  O     . HOH F 4 .   ? 6.360   -28.520 20.151  1.000 34.207  0 642 HOH A O     1 ? 
HETATM 2850 O  O     . HOH F 4 .   ? 0.170   10.259  18.046  1.000 35.887  0 643 HOH A O     1 ? 
HETATM 2851 O  O     . HOH F 4 .   ? 2.578   -8.777  8.337   1.000 16.742  0 644 HOH A O     1 ? 
HETATM 2852 O  O     . HOH F 4 .   ? 26.851  -4.730  19.144  1.000 23.078  0 645 HOH A O     1 ? 
HETATM 2853 O  O     . HOH F 4 .   ? 7.085   -6.474  16.927  1.000 24.584  0 646 HOH A O     1 ? 
HETATM 2854 O  O     . HOH F 4 .   ? 3.080   4.942   24.471  1.000 39.288  0 647 HOH A O     1 ? 
HETATM 2855 O  O     . HOH F 4 .   ? 25.428  -2.006  -16.545 1.000 36.387  0 648 HOH A O     1 ? 
HETATM 2856 O  O     . HOH F 4 .   ? 24.699  -26.705 24.571  1.000 37.820  0 649 HOH A O     1 ? 
HETATM 2857 O  O     . HOH F 4 .   ? 24.279  2.626   -9.146  1.000 42.239  0 650 HOH A O     1 ? 
HETATM 2858 O  O     . HOH F 4 .   ? 26.345  -3.340  21.628  1.000 39.812  0 651 HOH A O     1 ? 
HETATM 2859 O  O     . HOH F 4 .   ? 21.102  0.121   21.895  1.000 23.265  0 652 HOH A O     1 ? 
HETATM 2860 O  O     . HOH F 4 .   ? 16.532  4.195   -2.981  1.000 28.935  0 653 HOH A O     1 ? 
HETATM 2861 O  O     . HOH F 4 .   ? 26.470  1.829   11.942  1.000 51.448  0 654 HOH A O     1 ? 
HETATM 2862 O  O     . HOH F 4 .   ? 19.820  -7.438  -10.565 1.000 21.533  0 655 HOH A O     1 ? 
HETATM 2863 O  O     . HOH F 4 .   ? 24.042  9.969   18.846  1.000 44.354  0 656 HOH A O     1 ? 
HETATM 2864 O  O     . HOH F 4 .   ? 8.781   -21.030 19.830  1.000 17.975  0 657 HOH A O     1 ? 
HETATM 2865 O  O     . HOH F 4 .   ? 5.008   -20.057 19.575  1.000 45.352  0 658 HOH A O     1 ? 
HETATM 2866 O  O     . HOH F 4 .   ? -1.324  25.895  -3.996  1.000 29.244  0 659 HOH A O     1 ? 
HETATM 2867 O  O     . HOH F 4 .   ? 30.408  -0.175  11.405  1.000 42.662  0 660 HOH A O     1 ? 
HETATM 2868 O  O     . HOH F 4 .   ? 0.128   -15.391 8.785   1.000 22.676  0 661 HOH A O     1 ? 
HETATM 2869 O  O     . HOH F 4 .   ? 30.576  -10.824 -3.657  1.000 19.692  0 662 HOH A O     1 ? 
HETATM 2870 O  O     . HOH F 4 .   ? 26.812  -1.957  -10.806 1.000 23.419  0 663 HOH A O     1 ? 
HETATM 2871 O  O     . HOH F 4 .   ? -0.321  1.011   22.210  1.000 45.056  0 664 HOH A O     1 ? 
HETATM 2872 O  O     . HOH F 4 .   ? 33.621  -8.260  -0.986  1.000 31.443  0 665 HOH A O     1 ? 
HETATM 2873 O  O     . HOH F 4 .   ? 9.360   -18.022 19.726  1.000 22.289  0 666 HOH A O     1 ? 
HETATM 2874 O  O     . HOH F 4 .   ? 31.510  0.259   -8.155  1.000 20.688  0 667 HOH A O     1 ? 
HETATM 2875 O  O     . HOH F 4 .   ? -1.606  -1.764  -1.712  1.000 19.750  0 668 HOH A O     1 ? 
HETATM 2876 O  O     . HOH F 4 .   ? 0.444   -16.612 13.074  1.000 21.010  0 669 HOH A O     1 ? 
HETATM 2877 O  O     . HOH F 4 .   ? 25.042  -20.414 -0.106  1.000 33.156  0 670 HOH A O     1 ? 
HETATM 2878 O  O     . HOH F 4 .   ? 1.098   7.947   16.938  1.000 26.422  0 671 HOH A O     1 ? 
HETATM 2879 O  O     . HOH F 4 .   ? -3.356  -31.644 14.260  1.000 44.493  0 672 HOH A O     1 ? 
HETATM 2880 O  O     . HOH F 4 .   ? 12.764  -18.914 1.374   1.000 31.579  0 673 HOH A O     1 ? 
HETATM 2881 O  O     . HOH F 4 .   ? 26.273  -0.323  21.394  1.000 29.685  0 674 HOH A O     1 ? 
HETATM 2882 O  O     . HOH F 4 .   ? 3.852   -22.169 21.996  1.000 54.305  0 675 HOH A O     1 ? 
HETATM 2883 O  O     . HOH F 4 .   ? 35.358  1.382   -10.235 1.000 34.314  0 676 HOH A O     1 ? 
HETATM 2884 O  O     . HOH F 4 .   ? 0.616   -20.970 14.033  1.000 30.726  0 677 HOH A O     1 ? 
HETATM 2885 O  O     . HOH F 4 .   ? 8.139   -10.917 18.759  1.000 17.924  0 678 HOH A O     1 ? 
HETATM 2886 O  O     . HOH F 4 .   ? -0.932  -0.324  17.194  1.000 35.634  0 679 HOH A O     1 ? 
HETATM 2887 O  O     . HOH F 4 .   ? 26.680  -12.440 26.327  1.000 32.459  0 680 HOH A O     1 ? 
HETATM 2888 O  O     . HOH F 4 .   ? 36.075  -8.892  -16.978 1.000 43.557  0 681 HOH A O     1 ? 
HETATM 2889 O  O     . HOH F 4 .   ? 32.102  -17.388 5.974   1.000 31.292  0 682 HOH A O     1 ? 
HETATM 2890 O  O     . HOH F 4 .   ? 16.601  -23.212 5.381   1.000 31.985  0 683 HOH A O     1 ? 
HETATM 2891 O  O     . HOH F 4 .   ? 2.196   -19.837 17.787  1.000 33.112  0 684 HOH A O     1 ? 
HETATM 2892 O  O     . HOH F 4 .   ? 30.541  -29.218 10.945  1.000 29.905  0 685 HOH A O     1 ? 
HETATM 2893 O  O     . HOH F 4 .   ? 0.913   -2.786  16.004  1.000 32.383  0 686 HOH A O     1 ? 
HETATM 2894 O  O     . HOH F 4 .   ? 28.030  -23.602 26.226  1.000 39.287  0 687 HOH A O     1 ? 
HETATM 2895 O  O     . HOH F 4 .   ? 6.499   -30.035 16.301  1.000 46.788  0 688 HOH A O     1 ? 
HETATM 2896 O  O     . HOH F 4 .   ? 2.552   -4.868  14.656  1.000 26.853  0 689 HOH A O     1 ? 
HETATM 2897 O  O     . HOH F 4 .   ? 0.368   -9.341  -2.033  1.000 32.319  0 690 HOH A O     1 ? 
HETATM 2898 O  O     . HOH F 4 .   ? 29.980  -0.576  4.755   1.000 25.711  0 691 HOH A O     1 ? 
HETATM 2899 O  O     . HOH F 4 .   ? 4.020   -7.003  10.464  1.000 19.126  0 692 HOH A O     1 ? 
HETATM 2900 O  O     . HOH F 4 .   ? -3.040  -31.062 23.025  1.000 41.737  0 693 HOH A O     1 ? 
HETATM 2901 O  O     . HOH F 4 .   ? -3.793  20.775  6.034   1.000 29.025  0 694 HOH A O     1 ? 
HETATM 2902 O  O     . HOH F 4 .   ? 6.654   -20.908 4.842   1.000 43.853  0 695 HOH A O     1 ? 
HETATM 2903 O  O     . HOH F 4 .   ? 15.515  -6.192  26.972  1.000 40.915  0 696 HOH A O     1 ? 
HETATM 2904 O  O     . HOH F 4 .   ? 6.300   16.907  -11.207 1.000 41.007  0 697 HOH A O     1 ? 
HETATM 2905 O  O     . HOH F 4 .   ? 11.929  -7.224  -6.708  1.000 23.118  0 698 HOH A O     1 ? 
HETATM 2906 O  O     . HOH F 4 .   ? 8.905   -9.775  21.047  1.000 13.093  0 699 HOH A O     1 ? 
HETATM 2907 O  O     . HOH F 4 .   ? 14.417  33.002  4.097   1.000 39.862  0 700 HOH A O     1 ? 
HETATM 2908 O  O     . HOH F 4 .   ? 8.266   -23.806 8.256   1.000 34.189  0 701 HOH A O     1 ? 
HETATM 2909 O  O     . HOH F 4 .   ? 1.355   -0.373  10.353  1.000 28.002  0 702 HOH A O     1 ? 
HETATM 2910 O  O     . HOH F 4 .   ? 4.351   -14.302 -0.476  1.000 38.133  0 703 HOH A O     1 ? 
HETATM 2911 O  O     . HOH F 4 .   ? 1.939   4.290   13.442  1.000 31.309  0 704 HOH A O     1 ? 
HETATM 2912 O  O     . HOH F 4 .   ? 1.457   30.060  -2.760  1.000 40.321  0 705 HOH A O     1 ? 
HETATM 2913 O  O     . HOH F 4 .   ? 2.968   -18.314 6.769   1.000 37.038  0 706 HOH A O     1 ? 
HETATM 2914 O  O     . HOH F 4 .   ? 23.691  -25.398 20.316  1.000 33.874  0 707 HOH A O     1 ? 
HETATM 2915 O  O     . HOH F 4 .   ? -1.578  5.254   14.189  1.000 44.245  0 708 HOH A O     1 ? 
HETATM 2916 O  O     . HOH F 4 .   ? 29.921  -12.762 -14.531 1.000 38.427  0 709 HOH A O     1 ? 
HETATM 2917 O  O     . HOH F 4 .   ? -0.507  23.549  10.140  1.000 29.537  0 710 HOH A O     1 ? 
HETATM 2918 O  O     . HOH F 4 .   ? 35.823  6.841   -21.837 1.000 40.122  0 711 HOH A O     1 ? 
HETATM 2919 O  O     . HOH F 4 .   ? 32.892  -10.292 16.913  1.000 32.110  0 712 HOH A O     1 ? 
HETATM 2920 O  O     . HOH F 4 .   ? 38.273  -3.719  -9.924  1.000 38.914  0 713 HOH A O     1 ? 
HETATM 2921 O  O     . HOH F 4 .   ? 31.713  -11.168 -11.453 1.000 42.020  0 714 HOH A O     1 ? 
HETATM 2922 O  O     . HOH F 4 .   ? 28.439  1.535   -22.329 1.000 27.249  0 715 HOH A O     1 ? 
HETATM 2923 O  O     . HOH F 4 .   ? -5.095  20.340  8.254   1.000 34.629  0 716 HOH A O     1 ? 
HETATM 2924 O  O     . HOH F 4 .   ? 6.263   -17.117 18.745  1.000 25.443  0 717 HOH A O     1 ? 
HETATM 2925 O  O     . HOH F 4 .   ? 29.419  -12.781 27.124  1.000 45.058  0 718 HOH A O     1 ? 
HETATM 2926 O  O     . HOH F 4 .   ? 7.268   -5.430  19.196  1.000 25.944  0 719 HOH A O     1 ? 
HETATM 2927 O  O     . HOH F 4 .   ? 30.393  -19.281 11.752  1.000 25.420  0 720 HOH A O     1 ? 
HETATM 2928 O  O     . HOH F 4 .   ? 35.046  -17.976 14.840  1.000 42.054  0 721 HOH A O     1 ? 
HETATM 2929 O  O     . HOH F 4 .   ? -4.885  24.635  -7.769  1.000 44.701  0 722 HOH A O     1 ? 
HETATM 2930 O  O     . HOH F 4 .   ? 7.828   -4.844  24.958  1.000 41.301  0 723 HOH A O     1 ? 
HETATM 2931 O  O     . HOH F 4 .   ? 21.800  -11.273 -15.014 1.000 35.026  0 724 HOH A O     1 ? 
HETATM 2932 O  O     . HOH F 4 .   ? 1.604   -9.758  0.642   1.000 25.576  0 725 HOH A O     1 ? 
HETATM 2933 O  O     . HOH F 4 .   ? 29.893  2.736   -20.844 1.000 35.306  0 726 HOH A O     1 ? 
HETATM 2934 O  O     . HOH F 4 .   ? -0.954  7.051   19.859  1.000 45.345  0 727 HOH A O     1 ? 
HETATM 2935 O  O     . HOH F 4 .   ? 14.431  -21.365 0.964   1.000 30.460  0 728 HOH A O     1 ? 
HETATM 2936 O  O     . HOH F 4 .   ? 11.879  -18.631 23.059  1.000 22.363  0 729 HOH A O     1 ? 
HETATM 2937 O  O     . HOH F 4 .   ? 0.077   12.132  14.439  1.000 37.228  0 730 HOH A O     1 ? 
HETATM 2938 O  O     . HOH F 4 .   ? 33.065  1.972   -6.899  1.000 29.388  0 731 HOH A O     1 ? 
HETATM 2939 O  O     . HOH F 4 .   ? 10.854  -19.065 -0.641  1.000 35.871  0 732 HOH A O     1 ? 
HETATM 2940 O  O     . HOH F 4 .   ? 8.502   -2.949  22.393  1.000 38.016  0 733 HOH A O     1 ? 
HETATM 2941 O  O     . HOH F 4 .   ? 4.020   -12.055 21.248  1.000 35.961  0 734 HOH A O     1 ? 
HETATM 2942 O  O     . HOH F 4 .   ? 4.512   -4.842  -7.968  1.000 19.299  0 735 HOH A O     1 ? 
HETATM 2943 O  O     . HOH F 4 .   ? 30.144  -10.862 20.867  1.000 33.890  0 736 HOH A O     1 ? 
HETATM 2944 O  O     . HOH F 4 .   ? 10.476  -8.907  -7.128  1.000 48.036  0 737 HOH A O     1 ? 
HETATM 2945 O  O     . HOH F 4 .   ? 7.470   6.459   28.270  1.000 38.670  0 738 HOH A O     1 ? 
HETATM 2946 O  O     . HOH F 4 .   ? 13.322  2.699   24.506  1.000 35.369  0 739 HOH A O     1 ? 
HETATM 2947 O  O     . HOH F 4 .   ? 30.303  -11.960 -5.736  1.000 34.838  0 740 HOH A O     1 ? 
HETATM 2948 O  O     . HOH F 4 .   ? 39.801  -7.296  -8.649  1.000 38.298  0 741 HOH A O     1 ? 
HETATM 2949 O  O     . HOH F 4 .   ? 1.026   -16.613 4.421   1.000 42.908  0 742 HOH A O     1 ? 
HETATM 2950 O  O     . HOH F 4 .   ? 32.048  -6.864  18.533  1.000 41.360  0 743 HOH A O     1 ? 
HETATM 2951 O  O     . HOH F 4 .   ? 11.778  -16.933 24.790  1.000 41.330  0 744 HOH A O     1 ? 
# 
