data_8YST
# 
_entry.id   8YST 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YST         pdb_00008yst 10.2210/pdb8yst/pdb 
WWPDB D_1300046312 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YST 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              xiangzheng@pkusz.edu.cn 
_pdbx_contact_author.name_first         Zheng 
_pdbx_contact_author.name_last          Xiang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2925-842X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, H.Q.' 1 0009-0002-5724-8624 
'Xiang, Z.'  2 0000-0003-2925-842X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Protein Sci.' 
_citation.journal_id_ASTM           PRCIEI 
_citation.journal_id_CSD            0795 
_citation.journal_id_ISSN           1469-896X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            33 
_citation.language                  ? 
_citation.page_first                e5130 
_citation.page_last                 e5130 
_citation.title                     
'Structural insights into type III polyketide synthase CylI from cylindrocyclophane biosynthesis.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/pro.5130 
_citation.pdbx_database_id_PubMed   39302095 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wang, H.Q.' 1 ?                   
primary 'Xiang, Z.'  2 0000-0003-2925-842X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man CylI                        43227.328 2   ? ? ? ? 
2 non-polymer syn 3-oxidanylidenetetradecanal 226.355   1   ? ? ? ? 
3 water       nat water                       18.015    538 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Type III polyketide synthase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGENLYFQGHMTYIVSTSTAFPENYYPQTVLAAALRRFFTVMELDFDLEQIDRFFTNVKIDGRYFALPL
DSLLDPPTWGVSISRGLENSLNLAETAITKLLEKTNVQPQDISLLASVSMTPAIPSLDGRLMNRIPFSSTLKRLPMNGVG
CMGGAFGISRVADYLKAHPKEAAILFAVEISSALWQGSLQANLTSLIRRLPENPSLYSEIIMDIITAALFADGCGAVLMV
GKEHPLAKSGLPQVIDNRSFLVPNTVELMGLDVVDNGFRNILRPEVSDALKQGLRPLINGLLADNNIESENLYRWIVHPG
GPKVIDTVEAEFGLDSQTLQLSRDTLAEVGNISSATVLYMLDKVLSEEQSPPDSYGLIVAMGPGLAQEAILLKW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGENLYFQGHMTYIVSTSTAFPENYYPQTVLAAALRRFFTVMELDFDLEQIDRFFTNVKIDGRYFALPL
DSLLDPPTWGVSISRGLENSLNLAETAITKLLEKTNVQPQDISLLASVSMTPAIPSLDGRLMNRIPFSSTLKRLPMNGVG
CMGGAFGISRVADYLKAHPKEAAILFAVEISSALWQGSLQANLTSLIRRLPENPSLYSEIIMDIITAALFADGCGAVLMV
GKEHPLAKSGLPQVIDNRSFLVPNTVELMGLDVVDNGFRNILRPEVSDALKQGLRPLINGLLADNNIESENLYRWIVHPG
GPKVIDTVEAEFGLDSQTLQLSRDTLAEVGNISSATVLYMLDKVLSEEQSPPDSYGLIVAMGPGLAQEAILLKW
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 3-oxidanylidenetetradecanal A1D7D 
3 water                       HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  GLU n 
1 15  ASN n 
1 16  LEU n 
1 17  TYR n 
1 18  PHE n 
1 19  GLN n 
1 20  GLY n 
1 21  HIS n 
1 22  MET n 
1 23  THR n 
1 24  TYR n 
1 25  ILE n 
1 26  VAL n 
1 27  SER n 
1 28  THR n 
1 29  SER n 
1 30  THR n 
1 31  ALA n 
1 32  PHE n 
1 33  PRO n 
1 34  GLU n 
1 35  ASN n 
1 36  TYR n 
1 37  TYR n 
1 38  PRO n 
1 39  GLN n 
1 40  THR n 
1 41  VAL n 
1 42  LEU n 
1 43  ALA n 
1 44  ALA n 
1 45  ALA n 
1 46  LEU n 
1 47  ARG n 
1 48  ARG n 
1 49  PHE n 
1 50  PHE n 
1 51  THR n 
1 52  VAL n 
1 53  MET n 
1 54  GLU n 
1 55  LEU n 
1 56  ASP n 
1 57  PHE n 
1 58  ASP n 
1 59  LEU n 
1 60  GLU n 
1 61  GLN n 
1 62  ILE n 
1 63  ASP n 
1 64  ARG n 
1 65  PHE n 
1 66  PHE n 
1 67  THR n 
1 68  ASN n 
1 69  VAL n 
1 70  LYS n 
1 71  ILE n 
1 72  ASP n 
1 73  GLY n 
1 74  ARG n 
1 75  TYR n 
1 76  PHE n 
1 77  ALA n 
1 78  LEU n 
1 79  PRO n 
1 80  LEU n 
1 81  ASP n 
1 82  SER n 
1 83  LEU n 
1 84  LEU n 
1 85  ASP n 
1 86  PRO n 
1 87  PRO n 
1 88  THR n 
1 89  TRP n 
1 90  GLY n 
1 91  VAL n 
1 92  SER n 
1 93  ILE n 
1 94  SER n 
1 95  ARG n 
1 96  GLY n 
1 97  LEU n 
1 98  GLU n 
1 99  ASN n 
1 100 SER n 
1 101 LEU n 
1 102 ASN n 
1 103 LEU n 
1 104 ALA n 
1 105 GLU n 
1 106 THR n 
1 107 ALA n 
1 108 ILE n 
1 109 THR n 
1 110 LYS n 
1 111 LEU n 
1 112 LEU n 
1 113 GLU n 
1 114 LYS n 
1 115 THR n 
1 116 ASN n 
1 117 VAL n 
1 118 GLN n 
1 119 PRO n 
1 120 GLN n 
1 121 ASP n 
1 122 ILE n 
1 123 SER n 
1 124 LEU n 
1 125 LEU n 
1 126 ALA n 
1 127 SER n 
1 128 VAL n 
1 129 SER n 
1 130 MET n 
1 131 THR n 
1 132 PRO n 
1 133 ALA n 
1 134 ILE n 
1 135 PRO n 
1 136 SER n 
1 137 LEU n 
1 138 ASP n 
1 139 GLY n 
1 140 ARG n 
1 141 LEU n 
1 142 MET n 
1 143 ASN n 
1 144 ARG n 
1 145 ILE n 
1 146 PRO n 
1 147 PHE n 
1 148 SER n 
1 149 SER n 
1 150 THR n 
1 151 LEU n 
1 152 LYS n 
1 153 ARG n 
1 154 LEU n 
1 155 PRO n 
1 156 MET n 
1 157 ASN n 
1 158 GLY n 
1 159 VAL n 
1 160 GLY n 
1 161 CYS n 
1 162 MET n 
1 163 GLY n 
1 164 GLY n 
1 165 ALA n 
1 166 PHE n 
1 167 GLY n 
1 168 ILE n 
1 169 SER n 
1 170 ARG n 
1 171 VAL n 
1 172 ALA n 
1 173 ASP n 
1 174 TYR n 
1 175 LEU n 
1 176 LYS n 
1 177 ALA n 
1 178 HIS n 
1 179 PRO n 
1 180 LYS n 
1 181 GLU n 
1 182 ALA n 
1 183 ALA n 
1 184 ILE n 
1 185 LEU n 
1 186 PHE n 
1 187 ALA n 
1 188 VAL n 
1 189 GLU n 
1 190 ILE n 
1 191 SER n 
1 192 SER n 
1 193 ALA n 
1 194 LEU n 
1 195 TRP n 
1 196 GLN n 
1 197 GLY n 
1 198 SER n 
1 199 LEU n 
1 200 GLN n 
1 201 ALA n 
1 202 ASN n 
1 203 LEU n 
1 204 THR n 
1 205 SER n 
1 206 LEU n 
1 207 ILE n 
1 208 ARG n 
1 209 ARG n 
1 210 LEU n 
1 211 PRO n 
1 212 GLU n 
1 213 ASN n 
1 214 PRO n 
1 215 SER n 
1 216 LEU n 
1 217 TYR n 
1 218 SER n 
1 219 GLU n 
1 220 ILE n 
1 221 ILE n 
1 222 MET n 
1 223 ASP n 
1 224 ILE n 
1 225 ILE n 
1 226 THR n 
1 227 ALA n 
1 228 ALA n 
1 229 LEU n 
1 230 PHE n 
1 231 ALA n 
1 232 ASP n 
1 233 GLY n 
1 234 CYS n 
1 235 GLY n 
1 236 ALA n 
1 237 VAL n 
1 238 LEU n 
1 239 MET n 
1 240 VAL n 
1 241 GLY n 
1 242 LYS n 
1 243 GLU n 
1 244 HIS n 
1 245 PRO n 
1 246 LEU n 
1 247 ALA n 
1 248 LYS n 
1 249 SER n 
1 250 GLY n 
1 251 LEU n 
1 252 PRO n 
1 253 GLN n 
1 254 VAL n 
1 255 ILE n 
1 256 ASP n 
1 257 ASN n 
1 258 ARG n 
1 259 SER n 
1 260 PHE n 
1 261 LEU n 
1 262 VAL n 
1 263 PRO n 
1 264 ASN n 
1 265 THR n 
1 266 VAL n 
1 267 GLU n 
1 268 LEU n 
1 269 MET n 
1 270 GLY n 
1 271 LEU n 
1 272 ASP n 
1 273 VAL n 
1 274 VAL n 
1 275 ASP n 
1 276 ASN n 
1 277 GLY n 
1 278 PHE n 
1 279 ARG n 
1 280 ASN n 
1 281 ILE n 
1 282 LEU n 
1 283 ARG n 
1 284 PRO n 
1 285 GLU n 
1 286 VAL n 
1 287 SER n 
1 288 ASP n 
1 289 ALA n 
1 290 LEU n 
1 291 LYS n 
1 292 GLN n 
1 293 GLY n 
1 294 LEU n 
1 295 ARG n 
1 296 PRO n 
1 297 LEU n 
1 298 ILE n 
1 299 ASN n 
1 300 GLY n 
1 301 LEU n 
1 302 LEU n 
1 303 ALA n 
1 304 ASP n 
1 305 ASN n 
1 306 ASN n 
1 307 ILE n 
1 308 GLU n 
1 309 SER n 
1 310 GLU n 
1 311 ASN n 
1 312 LEU n 
1 313 TYR n 
1 314 ARG n 
1 315 TRP n 
1 316 ILE n 
1 317 VAL n 
1 318 HIS n 
1 319 PRO n 
1 320 GLY n 
1 321 GLY n 
1 322 PRO n 
1 323 LYS n 
1 324 VAL n 
1 325 ILE n 
1 326 ASP n 
1 327 THR n 
1 328 VAL n 
1 329 GLU n 
1 330 ALA n 
1 331 GLU n 
1 332 PHE n 
1 333 GLY n 
1 334 LEU n 
1 335 ASP n 
1 336 SER n 
1 337 GLN n 
1 338 THR n 
1 339 LEU n 
1 340 GLN n 
1 341 LEU n 
1 342 SER n 
1 343 ARG n 
1 344 ASP n 
1 345 THR n 
1 346 LEU n 
1 347 ALA n 
1 348 GLU n 
1 349 VAL n 
1 350 GLY n 
1 351 ASN n 
1 352 ILE n 
1 353 SER n 
1 354 SER n 
1 355 ALA n 
1 356 THR n 
1 357 VAL n 
1 358 LEU n 
1 359 TYR n 
1 360 MET n 
1 361 LEU n 
1 362 ASP n 
1 363 LYS n 
1 364 VAL n 
1 365 LEU n 
1 366 SER n 
1 367 GLU n 
1 368 GLU n 
1 369 GLN n 
1 370 SER n 
1 371 PRO n 
1 372 PRO n 
1 373 ASP n 
1 374 SER n 
1 375 TYR n 
1 376 GLY n 
1 377 LEU n 
1 378 ILE n 
1 379 VAL n 
1 380 ALA n 
1 381 MET n 
1 382 GLY n 
1 383 PRO n 
1 384 GLY n 
1 385 LEU n 
1 386 ALA n 
1 387 GLN n 
1 388 GLU n 
1 389 ALA n 
1 390 ILE n 
1 391 LEU n 
1 392 LEU n 
1 393 LYS n 
1 394 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   394 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 cylI 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Cylindrospermum licheniforme UTEX B 2014' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     379530 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D7D non-polymer         . 3-oxidanylidenetetradecanal ? 'C14 H26 O2'     226.355 
ALA   'L-peptide linking' y ALANINE                     ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                    ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                  ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'             ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE                    ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE                   ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'             ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                     ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                   ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                       ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                  ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                     ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                      ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                  ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE               ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                     ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                      ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                   ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                  ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                    ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                      ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -20 ?   ?   ?   A . n 
A 1 2   GLY 2   -19 ?   ?   ?   A . n 
A 1 3   SER 3   -18 ?   ?   ?   A . n 
A 1 4   SER 4   -17 ?   ?   ?   A . n 
A 1 5   HIS 5   -16 ?   ?   ?   A . n 
A 1 6   HIS 6   -15 ?   ?   ?   A . n 
A 1 7   HIS 7   -14 ?   ?   ?   A . n 
A 1 8   HIS 8   -13 ?   ?   ?   A . n 
A 1 9   HIS 9   -12 ?   ?   ?   A . n 
A 1 10  HIS 10  -11 ?   ?   ?   A . n 
A 1 11  SER 11  -10 ?   ?   ?   A . n 
A 1 12  SER 12  -9  ?   ?   ?   A . n 
A 1 13  GLY 13  -8  ?   ?   ?   A . n 
A 1 14  GLU 14  -7  ?   ?   ?   A . n 
A 1 15  ASN 15  -6  ?   ?   ?   A . n 
A 1 16  LEU 16  -5  ?   ?   ?   A . n 
A 1 17  TYR 17  -4  ?   ?   ?   A . n 
A 1 18  PHE 18  -3  ?   ?   ?   A . n 
A 1 19  GLN 19  -2  ?   ?   ?   A . n 
A 1 20  GLY 20  -1  ?   ?   ?   A . n 
A 1 21  HIS 21  0   ?   ?   ?   A . n 
A 1 22  MET 22  1   1   MET MET A . n 
A 1 23  THR 23  2   2   THR THR A . n 
A 1 24  TYR 24  3   3   TYR TYR A . n 
A 1 25  ILE 25  4   4   ILE ILE A . n 
A 1 26  VAL 26  5   5   VAL VAL A . n 
A 1 27  SER 27  6   6   SER SER A . n 
A 1 28  THR 28  7   7   THR THR A . n 
A 1 29  SER 29  8   8   SER SER A . n 
A 1 30  THR 30  9   9   THR THR A . n 
A 1 31  ALA 31  10  10  ALA ALA A . n 
A 1 32  PHE 32  11  11  PHE PHE A . n 
A 1 33  PRO 33  12  12  PRO PRO A . n 
A 1 34  GLU 34  13  13  GLU GLU A . n 
A 1 35  ASN 35  14  14  ASN ASN A . n 
A 1 36  TYR 36  15  15  TYR TYR A . n 
A 1 37  TYR 37  16  16  TYR TYR A . n 
A 1 38  PRO 38  17  17  PRO PRO A . n 
A 1 39  GLN 39  18  18  GLN GLN A . n 
A 1 40  THR 40  19  19  THR THR A . n 
A 1 41  VAL 41  20  20  VAL VAL A . n 
A 1 42  LEU 42  21  21  LEU LEU A . n 
A 1 43  ALA 43  22  22  ALA ALA A . n 
A 1 44  ALA 44  23  23  ALA ALA A . n 
A 1 45  ALA 45  24  24  ALA ALA A . n 
A 1 46  LEU 46  25  25  LEU LEU A . n 
A 1 47  ARG 47  26  26  ARG ARG A . n 
A 1 48  ARG 48  27  27  ARG ARG A . n 
A 1 49  PHE 49  28  28  PHE PHE A . n 
A 1 50  PHE 50  29  29  PHE PHE A . n 
A 1 51  THR 51  30  30  THR THR A . n 
A 1 52  VAL 52  31  31  VAL VAL A . n 
A 1 53  MET 53  32  32  MET MET A . n 
A 1 54  GLU 54  33  33  GLU GLU A . n 
A 1 55  LEU 55  34  34  LEU LEU A . n 
A 1 56  ASP 56  35  35  ASP ASP A . n 
A 1 57  PHE 57  36  36  PHE PHE A . n 
A 1 58  ASP 58  37  37  ASP ASP A . n 
A 1 59  LEU 59  38  38  LEU LEU A . n 
A 1 60  GLU 60  39  39  GLU GLU A . n 
A 1 61  GLN 61  40  40  GLN GLN A . n 
A 1 62  ILE 62  41  41  ILE ILE A . n 
A 1 63  ASP 63  42  42  ASP ASP A . n 
A 1 64  ARG 64  43  43  ARG ARG A . n 
A 1 65  PHE 65  44  44  PHE PHE A . n 
A 1 66  PHE 66  45  45  PHE PHE A . n 
A 1 67  THR 67  46  46  THR THR A . n 
A 1 68  ASN 68  47  47  ASN ASN A . n 
A 1 69  VAL 69  48  48  VAL VAL A . n 
A 1 70  LYS 70  49  49  LYS LYS A . n 
A 1 71  ILE 71  50  50  ILE ILE A . n 
A 1 72  ASP 72  51  51  ASP ASP A . n 
A 1 73  GLY 73  52  52  GLY GLY A . n 
A 1 74  ARG 74  53  53  ARG ARG A . n 
A 1 75  TYR 75  54  54  TYR TYR A . n 
A 1 76  PHE 76  55  55  PHE PHE A . n 
A 1 77  ALA 77  56  56  ALA ALA A . n 
A 1 78  LEU 78  57  57  LEU LEU A . n 
A 1 79  PRO 79  58  58  PRO PRO A . n 
A 1 80  LEU 80  59  59  LEU LEU A . n 
A 1 81  ASP 81  60  60  ASP ASP A . n 
A 1 82  SER 82  61  61  SER SER A . n 
A 1 83  LEU 83  62  62  LEU LEU A . n 
A 1 84  LEU 84  63  63  LEU LEU A . n 
A 1 85  ASP 85  64  64  ASP ASP A . n 
A 1 86  PRO 86  65  65  PRO PRO A . n 
A 1 87  PRO 87  66  66  PRO PRO A . n 
A 1 88  THR 88  67  67  THR THR A . n 
A 1 89  TRP 89  68  68  TRP TRP A . n 
A 1 90  GLY 90  69  69  GLY GLY A . n 
A 1 91  VAL 91  70  70  VAL VAL A . n 
A 1 92  SER 92  71  71  SER SER A . n 
A 1 93  ILE 93  72  72  ILE ILE A . n 
A 1 94  SER 94  73  73  SER SER A . n 
A 1 95  ARG 95  74  74  ARG ARG A . n 
A 1 96  GLY 96  75  75  GLY GLY A . n 
A 1 97  LEU 97  76  76  LEU LEU A . n 
A 1 98  GLU 98  77  77  GLU GLU A . n 
A 1 99  ASN 99  78  78  ASN ASN A . n 
A 1 100 SER 100 79  79  SER SER A . n 
A 1 101 LEU 101 80  80  LEU LEU A . n 
A 1 102 ASN 102 81  81  ASN ASN A . n 
A 1 103 LEU 103 82  82  LEU LEU A . n 
A 1 104 ALA 104 83  83  ALA ALA A . n 
A 1 105 GLU 105 84  84  GLU GLU A . n 
A 1 106 THR 106 85  85  THR THR A . n 
A 1 107 ALA 107 86  86  ALA ALA A . n 
A 1 108 ILE 108 87  87  ILE ILE A . n 
A 1 109 THR 109 88  88  THR THR A . n 
A 1 110 LYS 110 89  89  LYS LYS A . n 
A 1 111 LEU 111 90  90  LEU LEU A . n 
A 1 112 LEU 112 91  91  LEU LEU A . n 
A 1 113 GLU 113 92  92  GLU GLU A . n 
A 1 114 LYS 114 93  93  LYS LYS A . n 
A 1 115 THR 115 94  94  THR THR A . n 
A 1 116 ASN 116 95  95  ASN ASN A . n 
A 1 117 VAL 117 96  96  VAL VAL A . n 
A 1 118 GLN 118 97  97  GLN GLN A . n 
A 1 119 PRO 119 98  98  PRO PRO A . n 
A 1 120 GLN 120 99  99  GLN GLN A . n 
A 1 121 ASP 121 100 100 ASP ASP A . n 
A 1 122 ILE 122 101 101 ILE ILE A . n 
A 1 123 SER 123 102 102 SER SER A . n 
A 1 124 LEU 124 103 103 LEU LEU A . n 
A 1 125 LEU 125 104 104 LEU LEU A . n 
A 1 126 ALA 126 105 105 ALA ALA A . n 
A 1 127 SER 127 106 106 SER SER A . n 
A 1 128 VAL 128 107 107 VAL VAL A . n 
A 1 129 SER 129 108 108 SER SER A . n 
A 1 130 MET 130 109 109 MET MET A . n 
A 1 131 THR 131 110 110 THR THR A . n 
A 1 132 PRO 132 111 111 PRO PRO A . n 
A 1 133 ALA 133 112 112 ALA ALA A . n 
A 1 134 ILE 134 113 113 ILE ILE A . n 
A 1 135 PRO 135 114 114 PRO PRO A . n 
A 1 136 SER 136 115 115 SER SER A . n 
A 1 137 LEU 137 116 116 LEU LEU A . n 
A 1 138 ASP 138 117 117 ASP ASP A . n 
A 1 139 GLY 139 118 118 GLY GLY A . n 
A 1 140 ARG 140 119 119 ARG ARG A . n 
A 1 141 LEU 141 120 120 LEU LEU A . n 
A 1 142 MET 142 121 121 MET MET A . n 
A 1 143 ASN 143 122 122 ASN ASN A . n 
A 1 144 ARG 144 123 123 ARG ARG A . n 
A 1 145 ILE 145 124 124 ILE ILE A . n 
A 1 146 PRO 146 125 125 PRO PRO A . n 
A 1 147 PHE 147 126 126 PHE PHE A . n 
A 1 148 SER 148 127 127 SER SER A . n 
A 1 149 SER 149 128 128 SER SER A . n 
A 1 150 THR 150 129 129 THR THR A . n 
A 1 151 LEU 151 130 130 LEU LEU A . n 
A 1 152 LYS 152 131 131 LYS LYS A . n 
A 1 153 ARG 153 132 132 ARG ARG A . n 
A 1 154 LEU 154 133 133 LEU LEU A . n 
A 1 155 PRO 155 134 134 PRO PRO A . n 
A 1 156 MET 156 135 135 MET MET A . n 
A 1 157 ASN 157 136 136 ASN ASN A . n 
A 1 158 GLY 158 137 137 GLY GLY A . n 
A 1 159 VAL 159 138 138 VAL VAL A . n 
A 1 160 GLY 160 139 139 GLY GLY A . n 
A 1 161 CYS 161 140 140 CYS CYS A . n 
A 1 162 MET 162 141 141 MET MET A . n 
A 1 163 GLY 163 142 142 GLY GLY A . n 
A 1 164 GLY 164 143 143 GLY GLY A . n 
A 1 165 ALA 165 144 144 ALA ALA A . n 
A 1 166 PHE 166 145 145 PHE PHE A . n 
A 1 167 GLY 167 146 146 GLY GLY A . n 
A 1 168 ILE 168 147 147 ILE ILE A . n 
A 1 169 SER 169 148 148 SER SER A . n 
A 1 170 ARG 170 149 149 ARG ARG A . n 
A 1 171 VAL 171 150 150 VAL VAL A . n 
A 1 172 ALA 172 151 151 ALA ALA A . n 
A 1 173 ASP 173 152 152 ASP ASP A . n 
A 1 174 TYR 174 153 153 TYR TYR A . n 
A 1 175 LEU 175 154 154 LEU LEU A . n 
A 1 176 LYS 176 155 155 LYS LYS A . n 
A 1 177 ALA 177 156 156 ALA ALA A . n 
A 1 178 HIS 178 157 157 HIS HIS A . n 
A 1 179 PRO 179 158 158 PRO PRO A . n 
A 1 180 LYS 180 159 159 LYS LYS A . n 
A 1 181 GLU 181 160 160 GLU GLU A . n 
A 1 182 ALA 182 161 161 ALA ALA A . n 
A 1 183 ALA 183 162 162 ALA ALA A . n 
A 1 184 ILE 184 163 163 ILE ILE A . n 
A 1 185 LEU 185 164 164 LEU LEU A . n 
A 1 186 PHE 186 165 165 PHE PHE A . n 
A 1 187 ALA 187 166 166 ALA ALA A . n 
A 1 188 VAL 188 167 167 VAL VAL A . n 
A 1 189 GLU 189 168 168 GLU GLU A . n 
A 1 190 ILE 190 169 169 ILE ILE A . n 
A 1 191 SER 191 170 170 SER SER A . n 
A 1 192 SER 192 171 171 SER SER A . n 
A 1 193 ALA 193 172 172 ALA ALA A . n 
A 1 194 LEU 194 173 173 LEU LEU A . n 
A 1 195 TRP 195 174 174 TRP TRP A . n 
A 1 196 GLN 196 175 175 GLN GLN A . n 
A 1 197 GLY 197 176 176 GLY GLY A . n 
A 1 198 SER 198 177 177 SER SER A . n 
A 1 199 LEU 199 178 178 LEU LEU A . n 
A 1 200 GLN 200 179 179 GLN GLN A . n 
A 1 201 ALA 201 180 180 ALA ALA A . n 
A 1 202 ASN 202 181 181 ASN ASN A . n 
A 1 203 LEU 203 182 182 LEU LEU A . n 
A 1 204 THR 204 183 183 THR THR A . n 
A 1 205 SER 205 184 184 SER SER A . n 
A 1 206 LEU 206 185 185 LEU LEU A . n 
A 1 207 ILE 207 186 186 ILE ILE A . n 
A 1 208 ARG 208 187 187 ARG ARG A . n 
A 1 209 ARG 209 188 188 ARG ARG A . n 
A 1 210 LEU 210 189 189 LEU LEU A . n 
A 1 211 PRO 211 190 190 PRO PRO A . n 
A 1 212 GLU 212 191 191 GLU GLU A . n 
A 1 213 ASN 213 192 192 ASN ASN A . n 
A 1 214 PRO 214 193 193 PRO PRO A . n 
A 1 215 SER 215 194 194 SER SER A . n 
A 1 216 LEU 216 195 195 LEU LEU A . n 
A 1 217 TYR 217 196 196 TYR TYR A . n 
A 1 218 SER 218 197 197 SER SER A . n 
A 1 219 GLU 219 198 198 GLU GLU A . n 
A 1 220 ILE 220 199 199 ILE ILE A . n 
A 1 221 ILE 221 200 200 ILE ILE A . n 
A 1 222 MET 222 201 201 MET MET A . n 
A 1 223 ASP 223 202 202 ASP ASP A . n 
A 1 224 ILE 224 203 203 ILE ILE A . n 
A 1 225 ILE 225 204 204 ILE ILE A . n 
A 1 226 THR 226 205 205 THR THR A . n 
A 1 227 ALA 227 206 206 ALA ALA A . n 
A 1 228 ALA 228 207 207 ALA ALA A . n 
A 1 229 LEU 229 208 208 LEU LEU A . n 
A 1 230 PHE 230 209 209 PHE PHE A . n 
A 1 231 ALA 231 210 210 ALA ALA A . n 
A 1 232 ASP 232 211 211 ASP ASP A . n 
A 1 233 GLY 233 212 212 GLY GLY A . n 
A 1 234 CYS 234 213 213 CYS CYS A . n 
A 1 235 GLY 235 214 214 GLY GLY A . n 
A 1 236 ALA 236 215 215 ALA ALA A . n 
A 1 237 VAL 237 216 216 VAL VAL A . n 
A 1 238 LEU 238 217 217 LEU LEU A . n 
A 1 239 MET 239 218 218 MET MET A . n 
A 1 240 VAL 240 219 219 VAL VAL A . n 
A 1 241 GLY 241 220 220 GLY GLY A . n 
A 1 242 LYS 242 221 221 LYS LYS A . n 
A 1 243 GLU 243 222 222 GLU GLU A . n 
A 1 244 HIS 244 223 223 HIS HIS A . n 
A 1 245 PRO 245 224 224 PRO PRO A . n 
A 1 246 LEU 246 225 225 LEU LEU A . n 
A 1 247 ALA 247 226 226 ALA ALA A . n 
A 1 248 LYS 248 227 227 LYS LYS A . n 
A 1 249 SER 249 228 228 SER SER A . n 
A 1 250 GLY 250 229 229 GLY GLY A . n 
A 1 251 LEU 251 230 230 LEU LEU A . n 
A 1 252 PRO 252 231 231 PRO PRO A . n 
A 1 253 GLN 253 232 232 GLN GLN A . n 
A 1 254 VAL 254 233 233 VAL VAL A . n 
A 1 255 ILE 255 234 234 ILE ILE A . n 
A 1 256 ASP 256 235 235 ASP ASP A . n 
A 1 257 ASN 257 236 236 ASN ASN A . n 
A 1 258 ARG 258 237 237 ARG ARG A . n 
A 1 259 SER 259 238 238 SER SER A . n 
A 1 260 PHE 260 239 239 PHE PHE A . n 
A 1 261 LEU 261 240 240 LEU LEU A . n 
A 1 262 VAL 262 241 241 VAL VAL A . n 
A 1 263 PRO 263 242 242 PRO PRO A . n 
A 1 264 ASN 264 243 243 ASN ASN A . n 
A 1 265 THR 265 244 244 THR THR A . n 
A 1 266 VAL 266 245 245 VAL VAL A . n 
A 1 267 GLU 267 246 246 GLU GLU A . n 
A 1 268 LEU 268 247 247 LEU LEU A . n 
A 1 269 MET 269 248 248 MET MET A . n 
A 1 270 GLY 270 249 249 GLY GLY A . n 
A 1 271 LEU 271 250 250 LEU LEU A . n 
A 1 272 ASP 272 251 251 ASP ASP A . n 
A 1 273 VAL 273 252 252 VAL VAL A . n 
A 1 274 VAL 274 253 253 VAL VAL A . n 
A 1 275 ASP 275 254 ?   ?   ?   A . n 
A 1 276 ASN 276 255 ?   ?   ?   A . n 
A 1 277 GLY 277 256 256 GLY GLY A . n 
A 1 278 PHE 278 257 257 PHE PHE A . n 
A 1 279 ARG 279 258 258 ARG ARG A . n 
A 1 280 ASN 280 259 259 ASN ASN A . n 
A 1 281 ILE 281 260 260 ILE ILE A . n 
A 1 282 LEU 282 261 261 LEU LEU A . n 
A 1 283 ARG 283 262 262 ARG ARG A . n 
A 1 284 PRO 284 263 263 PRO PRO A . n 
A 1 285 GLU 285 264 264 GLU GLU A . n 
A 1 286 VAL 286 265 265 VAL VAL A . n 
A 1 287 SER 287 266 266 SER SER A . n 
A 1 288 ASP 288 267 267 ASP ASP A . n 
A 1 289 ALA 289 268 268 ALA ALA A . n 
A 1 290 LEU 290 269 269 LEU LEU A . n 
A 1 291 LYS 291 270 270 LYS LYS A . n 
A 1 292 GLN 292 271 271 GLN GLN A . n 
A 1 293 GLY 293 272 272 GLY GLY A . n 
A 1 294 LEU 294 273 273 LEU LEU A . n 
A 1 295 ARG 295 274 274 ARG ARG A . n 
A 1 296 PRO 296 275 275 PRO PRO A . n 
A 1 297 LEU 297 276 276 LEU LEU A . n 
A 1 298 ILE 298 277 277 ILE ILE A . n 
A 1 299 ASN 299 278 278 ASN ASN A . n 
A 1 300 GLY 300 279 279 GLY GLY A . n 
A 1 301 LEU 301 280 280 LEU LEU A . n 
A 1 302 LEU 302 281 281 LEU LEU A . n 
A 1 303 ALA 303 282 282 ALA ALA A . n 
A 1 304 ASP 304 283 283 ASP ASP A . n 
A 1 305 ASN 305 284 284 ASN ASN A . n 
A 1 306 ASN 306 285 285 ASN ASN A . n 
A 1 307 ILE 307 286 286 ILE ILE A . n 
A 1 308 GLU 308 287 287 GLU GLU A . n 
A 1 309 SER 309 288 288 SER SER A . n 
A 1 310 GLU 310 289 289 GLU GLU A . n 
A 1 311 ASN 311 290 290 ASN ASN A . n 
A 1 312 LEU 312 291 291 LEU LEU A . n 
A 1 313 TYR 313 292 292 TYR TYR A . n 
A 1 314 ARG 314 293 293 ARG ARG A . n 
A 1 315 TRP 315 294 294 TRP TRP A . n 
A 1 316 ILE 316 295 295 ILE ILE A . n 
A 1 317 VAL 317 296 296 VAL VAL A . n 
A 1 318 HIS 318 297 297 HIS HIS A . n 
A 1 319 PRO 319 298 298 PRO PRO A . n 
A 1 320 GLY 320 299 299 GLY GLY A . n 
A 1 321 GLY 321 300 300 GLY GLY A . n 
A 1 322 PRO 322 301 301 PRO PRO A . n 
A 1 323 LYS 323 302 302 LYS LYS A . n 
A 1 324 VAL 324 303 303 VAL VAL A . n 
A 1 325 ILE 325 304 304 ILE ILE A . n 
A 1 326 ASP 326 305 305 ASP ASP A . n 
A 1 327 THR 327 306 306 THR THR A . n 
A 1 328 VAL 328 307 307 VAL VAL A . n 
A 1 329 GLU 329 308 308 GLU GLU A . n 
A 1 330 ALA 330 309 309 ALA ALA A . n 
A 1 331 GLU 331 310 310 GLU GLU A . n 
A 1 332 PHE 332 311 311 PHE PHE A . n 
A 1 333 GLY 333 312 312 GLY GLY A . n 
A 1 334 LEU 334 313 313 LEU LEU A . n 
A 1 335 ASP 335 314 314 ASP ASP A . n 
A 1 336 SER 336 315 315 SER SER A . n 
A 1 337 GLN 337 316 316 GLN GLN A . n 
A 1 338 THR 338 317 317 THR THR A . n 
A 1 339 LEU 339 318 318 LEU LEU A . n 
A 1 340 GLN 340 319 319 GLN GLN A . n 
A 1 341 LEU 341 320 320 LEU LEU A . n 
A 1 342 SER 342 321 321 SER SER A . n 
A 1 343 ARG 343 322 322 ARG ARG A . n 
A 1 344 ASP 344 323 323 ASP ASP A . n 
A 1 345 THR 345 324 324 THR THR A . n 
A 1 346 LEU 346 325 325 LEU LEU A . n 
A 1 347 ALA 347 326 326 ALA ALA A . n 
A 1 348 GLU 348 327 327 GLU GLU A . n 
A 1 349 VAL 349 328 328 VAL VAL A . n 
A 1 350 GLY 350 329 329 GLY GLY A . n 
A 1 351 ASN 351 330 330 ASN ASN A . n 
A 1 352 ILE 352 331 331 ILE ILE A . n 
A 1 353 SER 353 332 332 SER SER A . n 
A 1 354 SER 354 333 333 SER SER A . n 
A 1 355 ALA 355 334 334 ALA ALA A . n 
A 1 356 THR 356 335 335 THR THR A . n 
A 1 357 VAL 357 336 336 VAL VAL A . n 
A 1 358 LEU 358 337 337 LEU LEU A . n 
A 1 359 TYR 359 338 338 TYR TYR A . n 
A 1 360 MET 360 339 339 MET MET A . n 
A 1 361 LEU 361 340 340 LEU LEU A . n 
A 1 362 ASP 362 341 341 ASP ASP A . n 
A 1 363 LYS 363 342 342 LYS LYS A . n 
A 1 364 VAL 364 343 343 VAL VAL A . n 
A 1 365 LEU 365 344 344 LEU LEU A . n 
A 1 366 SER 366 345 345 SER SER A . n 
A 1 367 GLU 367 346 346 GLU GLU A . n 
A 1 368 GLU 368 347 347 GLU GLU A . n 
A 1 369 GLN 369 348 348 GLN GLN A . n 
A 1 370 SER 370 349 349 SER SER A . n 
A 1 371 PRO 371 350 350 PRO PRO A . n 
A 1 372 PRO 372 351 351 PRO PRO A . n 
A 1 373 ASP 373 352 352 ASP ASP A . n 
A 1 374 SER 374 353 353 SER SER A . n 
A 1 375 TYR 375 354 354 TYR TYR A . n 
A 1 376 GLY 376 355 355 GLY GLY A . n 
A 1 377 LEU 377 356 356 LEU LEU A . n 
A 1 378 ILE 378 357 357 ILE ILE A . n 
A 1 379 VAL 379 358 358 VAL VAL A . n 
A 1 380 ALA 380 359 359 ALA ALA A . n 
A 1 381 MET 381 360 360 MET MET A . n 
A 1 382 GLY 382 361 361 GLY GLY A . n 
A 1 383 PRO 383 362 362 PRO PRO A . n 
A 1 384 GLY 384 363 363 GLY GLY A . n 
A 1 385 LEU 385 364 364 LEU LEU A . n 
A 1 386 ALA 386 365 365 ALA ALA A . n 
A 1 387 GLN 387 366 366 GLN GLN A . n 
A 1 388 GLU 388 367 367 GLU GLU A . n 
A 1 389 ALA 389 368 368 ALA ALA A . n 
A 1 390 ILE 390 369 369 ILE ILE A . n 
A 1 391 LEU 391 370 370 LEU LEU A . n 
A 1 392 LEU 392 371 371 LEU LEU A . n 
A 1 393 LYS 393 372 372 LYS LYS A . n 
A 1 394 TRP 394 373 373 TRP TRP A . n 
B 1 1   MET 1   -20 ?   ?   ?   B . n 
B 1 2   GLY 2   -19 ?   ?   ?   B . n 
B 1 3   SER 3   -18 ?   ?   ?   B . n 
B 1 4   SER 4   -17 ?   ?   ?   B . n 
B 1 5   HIS 5   -16 ?   ?   ?   B . n 
B 1 6   HIS 6   -15 ?   ?   ?   B . n 
B 1 7   HIS 7   -14 ?   ?   ?   B . n 
B 1 8   HIS 8   -13 ?   ?   ?   B . n 
B 1 9   HIS 9   -12 ?   ?   ?   B . n 
B 1 10  HIS 10  -11 ?   ?   ?   B . n 
B 1 11  SER 11  -10 ?   ?   ?   B . n 
B 1 12  SER 12  -9  ?   ?   ?   B . n 
B 1 13  GLY 13  -8  ?   ?   ?   B . n 
B 1 14  GLU 14  -7  ?   ?   ?   B . n 
B 1 15  ASN 15  -6  ?   ?   ?   B . n 
B 1 16  LEU 16  -5  ?   ?   ?   B . n 
B 1 17  TYR 17  -4  ?   ?   ?   B . n 
B 1 18  PHE 18  -3  ?   ?   ?   B . n 
B 1 19  GLN 19  -2  ?   ?   ?   B . n 
B 1 20  GLY 20  -1  ?   ?   ?   B . n 
B 1 21  HIS 21  0   ?   ?   ?   B . n 
B 1 22  MET 22  1   1   MET MET B . n 
B 1 23  THR 23  2   2   THR THR B . n 
B 1 24  TYR 24  3   3   TYR TYR B . n 
B 1 25  ILE 25  4   4   ILE ILE B . n 
B 1 26  VAL 26  5   5   VAL VAL B . n 
B 1 27  SER 27  6   6   SER SER B . n 
B 1 28  THR 28  7   7   THR THR B . n 
B 1 29  SER 29  8   8   SER SER B . n 
B 1 30  THR 30  9   9   THR THR B . n 
B 1 31  ALA 31  10  10  ALA ALA B . n 
B 1 32  PHE 32  11  11  PHE PHE B . n 
B 1 33  PRO 33  12  12  PRO PRO B . n 
B 1 34  GLU 34  13  13  GLU GLU B . n 
B 1 35  ASN 35  14  14  ASN ASN B . n 
B 1 36  TYR 36  15  15  TYR TYR B . n 
B 1 37  TYR 37  16  16  TYR TYR B . n 
B 1 38  PRO 38  17  17  PRO PRO B . n 
B 1 39  GLN 39  18  18  GLN GLN B . n 
B 1 40  THR 40  19  19  THR THR B . n 
B 1 41  VAL 41  20  20  VAL VAL B . n 
B 1 42  LEU 42  21  21  LEU LEU B . n 
B 1 43  ALA 43  22  22  ALA ALA B . n 
B 1 44  ALA 44  23  23  ALA ALA B . n 
B 1 45  ALA 45  24  24  ALA ALA B . n 
B 1 46  LEU 46  25  25  LEU LEU B . n 
B 1 47  ARG 47  26  26  ARG ARG B . n 
B 1 48  ARG 48  27  27  ARG ARG B . n 
B 1 49  PHE 49  28  28  PHE PHE B . n 
B 1 50  PHE 50  29  29  PHE PHE B . n 
B 1 51  THR 51  30  30  THR THR B . n 
B 1 52  VAL 52  31  31  VAL VAL B . n 
B 1 53  MET 53  32  32  MET MET B . n 
B 1 54  GLU 54  33  33  GLU GLU B . n 
B 1 55  LEU 55  34  34  LEU LEU B . n 
B 1 56  ASP 56  35  35  ASP ASP B . n 
B 1 57  PHE 57  36  36  PHE PHE B . n 
B 1 58  ASP 58  37  37  ASP ASP B . n 
B 1 59  LEU 59  38  38  LEU LEU B . n 
B 1 60  GLU 60  39  39  GLU GLU B . n 
B 1 61  GLN 61  40  40  GLN GLN B . n 
B 1 62  ILE 62  41  41  ILE ILE B . n 
B 1 63  ASP 63  42  42  ASP ASP B . n 
B 1 64  ARG 64  43  43  ARG ARG B . n 
B 1 65  PHE 65  44  44  PHE PHE B . n 
B 1 66  PHE 66  45  45  PHE PHE B . n 
B 1 67  THR 67  46  46  THR THR B . n 
B 1 68  ASN 68  47  47  ASN ASN B . n 
B 1 69  VAL 69  48  48  VAL VAL B . n 
B 1 70  LYS 70  49  49  LYS LYS B . n 
B 1 71  ILE 71  50  50  ILE ILE B . n 
B 1 72  ASP 72  51  51  ASP ASP B . n 
B 1 73  GLY 73  52  52  GLY GLY B . n 
B 1 74  ARG 74  53  53  ARG ARG B . n 
B 1 75  TYR 75  54  54  TYR TYR B . n 
B 1 76  PHE 76  55  55  PHE PHE B . n 
B 1 77  ALA 77  56  56  ALA ALA B . n 
B 1 78  LEU 78  57  57  LEU LEU B . n 
B 1 79  PRO 79  58  58  PRO PRO B . n 
B 1 80  LEU 80  59  59  LEU LEU B . n 
B 1 81  ASP 81  60  60  ASP ASP B . n 
B 1 82  SER 82  61  61  SER SER B . n 
B 1 83  LEU 83  62  62  LEU LEU B . n 
B 1 84  LEU 84  63  63  LEU LEU B . n 
B 1 85  ASP 85  64  64  ASP ASP B . n 
B 1 86  PRO 86  65  65  PRO PRO B . n 
B 1 87  PRO 87  66  66  PRO PRO B . n 
B 1 88  THR 88  67  67  THR THR B . n 
B 1 89  TRP 89  68  68  TRP TRP B . n 
B 1 90  GLY 90  69  69  GLY GLY B . n 
B 1 91  VAL 91  70  70  VAL VAL B . n 
B 1 92  SER 92  71  71  SER SER B . n 
B 1 93  ILE 93  72  72  ILE ILE B . n 
B 1 94  SER 94  73  73  SER SER B . n 
B 1 95  ARG 95  74  74  ARG ARG B . n 
B 1 96  GLY 96  75  75  GLY GLY B . n 
B 1 97  LEU 97  76  76  LEU LEU B . n 
B 1 98  GLU 98  77  77  GLU GLU B . n 
B 1 99  ASN 99  78  78  ASN ASN B . n 
B 1 100 SER 100 79  79  SER SER B . n 
B 1 101 LEU 101 80  80  LEU LEU B . n 
B 1 102 ASN 102 81  81  ASN ASN B . n 
B 1 103 LEU 103 82  82  LEU LEU B . n 
B 1 104 ALA 104 83  83  ALA ALA B . n 
B 1 105 GLU 105 84  84  GLU GLU B . n 
B 1 106 THR 106 85  85  THR THR B . n 
B 1 107 ALA 107 86  86  ALA ALA B . n 
B 1 108 ILE 108 87  87  ILE ILE B . n 
B 1 109 THR 109 88  88  THR THR B . n 
B 1 110 LYS 110 89  89  LYS LYS B . n 
B 1 111 LEU 111 90  90  LEU LEU B . n 
B 1 112 LEU 112 91  91  LEU LEU B . n 
B 1 113 GLU 113 92  92  GLU GLU B . n 
B 1 114 LYS 114 93  93  LYS LYS B . n 
B 1 115 THR 115 94  94  THR THR B . n 
B 1 116 ASN 116 95  95  ASN ASN B . n 
B 1 117 VAL 117 96  96  VAL VAL B . n 
B 1 118 GLN 118 97  97  GLN GLN B . n 
B 1 119 PRO 119 98  98  PRO PRO B . n 
B 1 120 GLN 120 99  99  GLN GLN B . n 
B 1 121 ASP 121 100 100 ASP ASP B . n 
B 1 122 ILE 122 101 101 ILE ILE B . n 
B 1 123 SER 123 102 102 SER SER B . n 
B 1 124 LEU 124 103 103 LEU LEU B . n 
B 1 125 LEU 125 104 104 LEU LEU B . n 
B 1 126 ALA 126 105 105 ALA ALA B . n 
B 1 127 SER 127 106 106 SER SER B . n 
B 1 128 VAL 128 107 107 VAL VAL B . n 
B 1 129 SER 129 108 108 SER SER B . n 
B 1 130 MET 130 109 109 MET MET B . n 
B 1 131 THR 131 110 110 THR THR B . n 
B 1 132 PRO 132 111 111 PRO PRO B . n 
B 1 133 ALA 133 112 112 ALA ALA B . n 
B 1 134 ILE 134 113 113 ILE ILE B . n 
B 1 135 PRO 135 114 114 PRO PRO B . n 
B 1 136 SER 136 115 115 SER SER B . n 
B 1 137 LEU 137 116 116 LEU LEU B . n 
B 1 138 ASP 138 117 117 ASP ASP B . n 
B 1 139 GLY 139 118 118 GLY GLY B . n 
B 1 140 ARG 140 119 119 ARG ARG B . n 
B 1 141 LEU 141 120 120 LEU LEU B . n 
B 1 142 MET 142 121 121 MET MET B . n 
B 1 143 ASN 143 122 122 ASN ASN B . n 
B 1 144 ARG 144 123 123 ARG ARG B . n 
B 1 145 ILE 145 124 124 ILE ILE B . n 
B 1 146 PRO 146 125 125 PRO PRO B . n 
B 1 147 PHE 147 126 126 PHE PHE B . n 
B 1 148 SER 148 127 127 SER SER B . n 
B 1 149 SER 149 128 128 SER SER B . n 
B 1 150 THR 150 129 129 THR THR B . n 
B 1 151 LEU 151 130 130 LEU LEU B . n 
B 1 152 LYS 152 131 131 LYS LYS B . n 
B 1 153 ARG 153 132 132 ARG ARG B . n 
B 1 154 LEU 154 133 133 LEU LEU B . n 
B 1 155 PRO 155 134 134 PRO PRO B . n 
B 1 156 MET 156 135 135 MET MET B . n 
B 1 157 ASN 157 136 136 ASN ASN B . n 
B 1 158 GLY 158 137 137 GLY GLY B . n 
B 1 159 VAL 159 138 138 VAL VAL B . n 
B 1 160 GLY 160 139 139 GLY GLY B . n 
B 1 161 CYS 161 140 140 CYS CYS B . n 
B 1 162 MET 162 141 141 MET MET B . n 
B 1 163 GLY 163 142 142 GLY GLY B . n 
B 1 164 GLY 164 143 143 GLY GLY B . n 
B 1 165 ALA 165 144 144 ALA ALA B . n 
B 1 166 PHE 166 145 145 PHE PHE B . n 
B 1 167 GLY 167 146 146 GLY GLY B . n 
B 1 168 ILE 168 147 147 ILE ILE B . n 
B 1 169 SER 169 148 148 SER SER B . n 
B 1 170 ARG 170 149 149 ARG ARG B . n 
B 1 171 VAL 171 150 150 VAL VAL B . n 
B 1 172 ALA 172 151 151 ALA ALA B . n 
B 1 173 ASP 173 152 152 ASP ASP B . n 
B 1 174 TYR 174 153 153 TYR TYR B . n 
B 1 175 LEU 175 154 154 LEU LEU B . n 
B 1 176 LYS 176 155 155 LYS LYS B . n 
B 1 177 ALA 177 156 156 ALA ALA B . n 
B 1 178 HIS 178 157 157 HIS HIS B . n 
B 1 179 PRO 179 158 158 PRO PRO B . n 
B 1 180 LYS 180 159 159 LYS LYS B . n 
B 1 181 GLU 181 160 160 GLU GLU B . n 
B 1 182 ALA 182 161 161 ALA ALA B . n 
B 1 183 ALA 183 162 162 ALA ALA B . n 
B 1 184 ILE 184 163 163 ILE ILE B . n 
B 1 185 LEU 185 164 164 LEU LEU B . n 
B 1 186 PHE 186 165 165 PHE PHE B . n 
B 1 187 ALA 187 166 166 ALA ALA B . n 
B 1 188 VAL 188 167 167 VAL VAL B . n 
B 1 189 GLU 189 168 168 GLU GLU B . n 
B 1 190 ILE 190 169 169 ILE ILE B . n 
B 1 191 SER 191 170 170 SER SER B . n 
B 1 192 SER 192 171 171 SER SER B . n 
B 1 193 ALA 193 172 172 ALA ALA B . n 
B 1 194 LEU 194 173 173 LEU LEU B . n 
B 1 195 TRP 195 174 174 TRP TRP B . n 
B 1 196 GLN 196 175 175 GLN GLN B . n 
B 1 197 GLY 197 176 176 GLY GLY B . n 
B 1 198 SER 198 177 177 SER SER B . n 
B 1 199 LEU 199 178 178 LEU LEU B . n 
B 1 200 GLN 200 179 179 GLN GLN B . n 
B 1 201 ALA 201 180 180 ALA ALA B . n 
B 1 202 ASN 202 181 181 ASN ASN B . n 
B 1 203 LEU 203 182 182 LEU LEU B . n 
B 1 204 THR 204 183 183 THR THR B . n 
B 1 205 SER 205 184 184 SER SER B . n 
B 1 206 LEU 206 185 185 LEU LEU B . n 
B 1 207 ILE 207 186 186 ILE ILE B . n 
B 1 208 ARG 208 187 187 ARG ARG B . n 
B 1 209 ARG 209 188 188 ARG ARG B . n 
B 1 210 LEU 210 189 189 LEU LEU B . n 
B 1 211 PRO 211 190 190 PRO PRO B . n 
B 1 212 GLU 212 191 191 GLU GLU B . n 
B 1 213 ASN 213 192 192 ASN ASN B . n 
B 1 214 PRO 214 193 193 PRO PRO B . n 
B 1 215 SER 215 194 194 SER SER B . n 
B 1 216 LEU 216 195 195 LEU LEU B . n 
B 1 217 TYR 217 196 196 TYR TYR B . n 
B 1 218 SER 218 197 197 SER SER B . n 
B 1 219 GLU 219 198 198 GLU GLU B . n 
B 1 220 ILE 220 199 199 ILE ILE B . n 
B 1 221 ILE 221 200 200 ILE ILE B . n 
B 1 222 MET 222 201 201 MET MET B . n 
B 1 223 ASP 223 202 202 ASP ASP B . n 
B 1 224 ILE 224 203 203 ILE ILE B . n 
B 1 225 ILE 225 204 204 ILE ILE B . n 
B 1 226 THR 226 205 205 THR THR B . n 
B 1 227 ALA 227 206 206 ALA ALA B . n 
B 1 228 ALA 228 207 207 ALA ALA B . n 
B 1 229 LEU 229 208 208 LEU LEU B . n 
B 1 230 PHE 230 209 209 PHE PHE B . n 
B 1 231 ALA 231 210 210 ALA ALA B . n 
B 1 232 ASP 232 211 211 ASP ASP B . n 
B 1 233 GLY 233 212 212 GLY GLY B . n 
B 1 234 CYS 234 213 213 CYS CYS B . n 
B 1 235 GLY 235 214 214 GLY GLY B . n 
B 1 236 ALA 236 215 215 ALA ALA B . n 
B 1 237 VAL 237 216 216 VAL VAL B . n 
B 1 238 LEU 238 217 217 LEU LEU B . n 
B 1 239 MET 239 218 218 MET MET B . n 
B 1 240 VAL 240 219 219 VAL VAL B . n 
B 1 241 GLY 241 220 220 GLY GLY B . n 
B 1 242 LYS 242 221 221 LYS LYS B . n 
B 1 243 GLU 243 222 222 GLU GLU B . n 
B 1 244 HIS 244 223 223 HIS HIS B . n 
B 1 245 PRO 245 224 224 PRO PRO B . n 
B 1 246 LEU 246 225 225 LEU LEU B . n 
B 1 247 ALA 247 226 226 ALA ALA B . n 
B 1 248 LYS 248 227 227 LYS LYS B . n 
B 1 249 SER 249 228 228 SER SER B . n 
B 1 250 GLY 250 229 229 GLY GLY B . n 
B 1 251 LEU 251 230 230 LEU LEU B . n 
B 1 252 PRO 252 231 231 PRO PRO B . n 
B 1 253 GLN 253 232 232 GLN GLN B . n 
B 1 254 VAL 254 233 233 VAL VAL B . n 
B 1 255 ILE 255 234 234 ILE ILE B . n 
B 1 256 ASP 256 235 235 ASP ASP B . n 
B 1 257 ASN 257 236 236 ASN ASN B . n 
B 1 258 ARG 258 237 237 ARG ARG B . n 
B 1 259 SER 259 238 238 SER SER B . n 
B 1 260 PHE 260 239 239 PHE PHE B . n 
B 1 261 LEU 261 240 240 LEU LEU B . n 
B 1 262 VAL 262 241 241 VAL VAL B . n 
B 1 263 PRO 263 242 242 PRO PRO B . n 
B 1 264 ASN 264 243 243 ASN ASN B . n 
B 1 265 THR 265 244 244 THR THR B . n 
B 1 266 VAL 266 245 245 VAL VAL B . n 
B 1 267 GLU 267 246 246 GLU GLU B . n 
B 1 268 LEU 268 247 247 LEU LEU B . n 
B 1 269 MET 269 248 248 MET MET B . n 
B 1 270 GLY 270 249 249 GLY GLY B . n 
B 1 271 LEU 271 250 250 LEU LEU B . n 
B 1 272 ASP 272 251 251 ASP ASP B . n 
B 1 273 VAL 273 252 252 VAL VAL B . n 
B 1 274 VAL 274 253 253 VAL VAL B . n 
B 1 275 ASP 275 254 254 ASP ASP B . n 
B 1 276 ASN 276 255 255 ASN ASN B . n 
B 1 277 GLY 277 256 256 GLY GLY B . n 
B 1 278 PHE 278 257 257 PHE PHE B . n 
B 1 279 ARG 279 258 258 ARG ARG B . n 
B 1 280 ASN 280 259 259 ASN ASN B . n 
B 1 281 ILE 281 260 260 ILE ILE B . n 
B 1 282 LEU 282 261 261 LEU LEU B . n 
B 1 283 ARG 283 262 262 ARG ARG B . n 
B 1 284 PRO 284 263 263 PRO PRO B . n 
B 1 285 GLU 285 264 264 GLU GLU B . n 
B 1 286 VAL 286 265 265 VAL VAL B . n 
B 1 287 SER 287 266 266 SER SER B . n 
B 1 288 ASP 288 267 267 ASP ASP B . n 
B 1 289 ALA 289 268 268 ALA ALA B . n 
B 1 290 LEU 290 269 269 LEU LEU B . n 
B 1 291 LYS 291 270 270 LYS LYS B . n 
B 1 292 GLN 292 271 271 GLN GLN B . n 
B 1 293 GLY 293 272 272 GLY GLY B . n 
B 1 294 LEU 294 273 273 LEU LEU B . n 
B 1 295 ARG 295 274 274 ARG ARG B . n 
B 1 296 PRO 296 275 275 PRO PRO B . n 
B 1 297 LEU 297 276 276 LEU LEU B . n 
B 1 298 ILE 298 277 277 ILE ILE B . n 
B 1 299 ASN 299 278 278 ASN ASN B . n 
B 1 300 GLY 300 279 279 GLY GLY B . n 
B 1 301 LEU 301 280 280 LEU LEU B . n 
B 1 302 LEU 302 281 281 LEU LEU B . n 
B 1 303 ALA 303 282 282 ALA ALA B . n 
B 1 304 ASP 304 283 283 ASP ASP B . n 
B 1 305 ASN 305 284 284 ASN ASN B . n 
B 1 306 ASN 306 285 285 ASN ASN B . n 
B 1 307 ILE 307 286 286 ILE ILE B . n 
B 1 308 GLU 308 287 287 GLU GLU B . n 
B 1 309 SER 309 288 288 SER SER B . n 
B 1 310 GLU 310 289 289 GLU GLU B . n 
B 1 311 ASN 311 290 290 ASN ASN B . n 
B 1 312 LEU 312 291 291 LEU LEU B . n 
B 1 313 TYR 313 292 292 TYR TYR B . n 
B 1 314 ARG 314 293 293 ARG ARG B . n 
B 1 315 TRP 315 294 294 TRP TRP B . n 
B 1 316 ILE 316 295 295 ILE ILE B . n 
B 1 317 VAL 317 296 296 VAL VAL B . n 
B 1 318 HIS 318 297 297 HIS HIS B . n 
B 1 319 PRO 319 298 298 PRO PRO B . n 
B 1 320 GLY 320 299 299 GLY GLY B . n 
B 1 321 GLY 321 300 300 GLY GLY B . n 
B 1 322 PRO 322 301 301 PRO PRO B . n 
B 1 323 LYS 323 302 302 LYS LYS B . n 
B 1 324 VAL 324 303 303 VAL VAL B . n 
B 1 325 ILE 325 304 304 ILE ILE B . n 
B 1 326 ASP 326 305 305 ASP ASP B . n 
B 1 327 THR 327 306 306 THR THR B . n 
B 1 328 VAL 328 307 307 VAL VAL B . n 
B 1 329 GLU 329 308 308 GLU GLU B . n 
B 1 330 ALA 330 309 309 ALA ALA B . n 
B 1 331 GLU 331 310 310 GLU GLU B . n 
B 1 332 PHE 332 311 311 PHE PHE B . n 
B 1 333 GLY 333 312 312 GLY GLY B . n 
B 1 334 LEU 334 313 313 LEU LEU B . n 
B 1 335 ASP 335 314 314 ASP ASP B . n 
B 1 336 SER 336 315 315 SER SER B . n 
B 1 337 GLN 337 316 316 GLN GLN B . n 
B 1 338 THR 338 317 317 THR THR B . n 
B 1 339 LEU 339 318 318 LEU LEU B . n 
B 1 340 GLN 340 319 319 GLN GLN B . n 
B 1 341 LEU 341 320 320 LEU LEU B . n 
B 1 342 SER 342 321 321 SER SER B . n 
B 1 343 ARG 343 322 322 ARG ARG B . n 
B 1 344 ASP 344 323 323 ASP ASP B . n 
B 1 345 THR 345 324 324 THR THR B . n 
B 1 346 LEU 346 325 325 LEU LEU B . n 
B 1 347 ALA 347 326 326 ALA ALA B . n 
B 1 348 GLU 348 327 327 GLU GLU B . n 
B 1 349 VAL 349 328 328 VAL VAL B . n 
B 1 350 GLY 350 329 329 GLY GLY B . n 
B 1 351 ASN 351 330 330 ASN ASN B . n 
B 1 352 ILE 352 331 331 ILE ILE B . n 
B 1 353 SER 353 332 332 SER SER B . n 
B 1 354 SER 354 333 333 SER SER B . n 
B 1 355 ALA 355 334 334 ALA ALA B . n 
B 1 356 THR 356 335 335 THR THR B . n 
B 1 357 VAL 357 336 336 VAL VAL B . n 
B 1 358 LEU 358 337 337 LEU LEU B . n 
B 1 359 TYR 359 338 338 TYR TYR B . n 
B 1 360 MET 360 339 339 MET MET B . n 
B 1 361 LEU 361 340 340 LEU LEU B . n 
B 1 362 ASP 362 341 341 ASP ASP B . n 
B 1 363 LYS 363 342 342 LYS LYS B . n 
B 1 364 VAL 364 343 343 VAL VAL B . n 
B 1 365 LEU 365 344 344 LEU LEU B . n 
B 1 366 SER 366 345 345 SER SER B . n 
B 1 367 GLU 367 346 346 GLU GLU B . n 
B 1 368 GLU 368 347 347 GLU GLU B . n 
B 1 369 GLN 369 348 348 GLN GLN B . n 
B 1 370 SER 370 349 349 SER SER B . n 
B 1 371 PRO 371 350 350 PRO PRO B . n 
B 1 372 PRO 372 351 351 PRO PRO B . n 
B 1 373 ASP 373 352 352 ASP ASP B . n 
B 1 374 SER 374 353 353 SER SER B . n 
B 1 375 TYR 375 354 354 TYR TYR B . n 
B 1 376 GLY 376 355 355 GLY GLY B . n 
B 1 377 LEU 377 356 356 LEU LEU B . n 
B 1 378 ILE 378 357 357 ILE ILE B . n 
B 1 379 VAL 379 358 358 VAL VAL B . n 
B 1 380 ALA 380 359 359 ALA ALA B . n 
B 1 381 MET 381 360 360 MET MET B . n 
B 1 382 GLY 382 361 361 GLY GLY B . n 
B 1 383 PRO 383 362 362 PRO PRO B . n 
B 1 384 GLY 384 363 363 GLY GLY B . n 
B 1 385 LEU 385 364 364 LEU LEU B . n 
B 1 386 ALA 386 365 365 ALA ALA B . n 
B 1 387 GLN 387 366 366 GLN GLN B . n 
B 1 388 GLU 388 367 367 GLU GLU B . n 
B 1 389 ALA 389 368 368 ALA ALA B . n 
B 1 390 ILE 390 369 369 ILE ILE B . n 
B 1 391 LEU 391 370 370 LEU LEU B . n 
B 1 392 LEU 392 371 371 LEU LEU B . n 
B 1 393 LYS 393 372 372 LYS LYS B . n 
B 1 394 TRP 394 373 373 TRP TRP B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D7D 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D7D 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 A1D7D 1   401 401 A1D7D LIG B . 
D 3 HOH   1   401 212 HOH   HOH A . 
D 3 HOH   2   402 493 HOH   HOH A . 
D 3 HOH   3   403 144 HOH   HOH A . 
D 3 HOH   4   404 202 HOH   HOH A . 
D 3 HOH   5   405 24  HOH   HOH A . 
D 3 HOH   6   406 125 HOH   HOH A . 
D 3 HOH   7   407 175 HOH   HOH A . 
D 3 HOH   8   408 283 HOH   HOH A . 
D 3 HOH   9   409 64  HOH   HOH A . 
D 3 HOH   10  410 62  HOH   HOH A . 
D 3 HOH   11  411 140 HOH   HOH A . 
D 3 HOH   12  412 436 HOH   HOH A . 
D 3 HOH   13  413 291 HOH   HOH A . 
D 3 HOH   14  414 211 HOH   HOH A . 
D 3 HOH   15  415 127 HOH   HOH A . 
D 3 HOH   16  416 338 HOH   HOH A . 
D 3 HOH   17  417 453 HOH   HOH A . 
D 3 HOH   18  418 431 HOH   HOH A . 
D 3 HOH   19  419 121 HOH   HOH A . 
D 3 HOH   20  420 158 HOH   HOH A . 
D 3 HOH   21  421 165 HOH   HOH A . 
D 3 HOH   22  422 224 HOH   HOH A . 
D 3 HOH   23  423 290 HOH   HOH A . 
D 3 HOH   24  424 420 HOH   HOH A . 
D 3 HOH   25  425 129 HOH   HOH A . 
D 3 HOH   26  426 355 HOH   HOH A . 
D 3 HOH   27  427 9   HOH   HOH A . 
D 3 HOH   28  428 312 HOH   HOH A . 
D 3 HOH   29  429 276 HOH   HOH A . 
D 3 HOH   30  430 111 HOH   HOH A . 
D 3 HOH   31  431 286 HOH   HOH A . 
D 3 HOH   32  432 7   HOH   HOH A . 
D 3 HOH   33  433 522 HOH   HOH A . 
D 3 HOH   34  434 43  HOH   HOH A . 
D 3 HOH   35  435 389 HOH   HOH A . 
D 3 HOH   36  436 424 HOH   HOH A . 
D 3 HOH   37  437 250 HOH   HOH A . 
D 3 HOH   38  438 188 HOH   HOH A . 
D 3 HOH   39  439 108 HOH   HOH A . 
D 3 HOH   40  440 362 HOH   HOH A . 
D 3 HOH   41  441 22  HOH   HOH A . 
D 3 HOH   42  442 207 HOH   HOH A . 
D 3 HOH   43  443 4   HOH   HOH A . 
D 3 HOH   44  444 208 HOH   HOH A . 
D 3 HOH   45  445 94  HOH   HOH A . 
D 3 HOH   46  446 296 HOH   HOH A . 
D 3 HOH   47  447 450 HOH   HOH A . 
D 3 HOH   48  448 78  HOH   HOH A . 
D 3 HOH   49  449 238 HOH   HOH A . 
D 3 HOH   50  450 341 HOH   HOH A . 
D 3 HOH   51  451 63  HOH   HOH A . 
D 3 HOH   52  452 112 HOH   HOH A . 
D 3 HOH   53  453 199 HOH   HOH A . 
D 3 HOH   54  454 260 HOH   HOH A . 
D 3 HOH   55  455 322 HOH   HOH A . 
D 3 HOH   56  456 177 HOH   HOH A . 
D 3 HOH   57  457 83  HOH   HOH A . 
D 3 HOH   58  458 65  HOH   HOH A . 
D 3 HOH   59  459 169 HOH   HOH A . 
D 3 HOH   60  460 304 HOH   HOH A . 
D 3 HOH   61  461 44  HOH   HOH A . 
D 3 HOH   62  462 485 HOH   HOH A . 
D 3 HOH   63  463 376 HOH   HOH A . 
D 3 HOH   64  464 68  HOH   HOH A . 
D 3 HOH   65  465 36  HOH   HOH A . 
D 3 HOH   66  466 18  HOH   HOH A . 
D 3 HOH   67  467 320 HOH   HOH A . 
D 3 HOH   68  468 510 HOH   HOH A . 
D 3 HOH   69  469 190 HOH   HOH A . 
D 3 HOH   70  470 77  HOH   HOH A . 
D 3 HOH   71  471 273 HOH   HOH A . 
D 3 HOH   72  472 216 HOH   HOH A . 
D 3 HOH   73  473 204 HOH   HOH A . 
D 3 HOH   74  474 128 HOH   HOH A . 
D 3 HOH   75  475 180 HOH   HOH A . 
D 3 HOH   76  476 1   HOH   HOH A . 
D 3 HOH   77  477 50  HOH   HOH A . 
D 3 HOH   78  478 301 HOH   HOH A . 
D 3 HOH   79  479 61  HOH   HOH A . 
D 3 HOH   80  480 418 HOH   HOH A . 
D 3 HOH   81  481 107 HOH   HOH A . 
D 3 HOH   82  482 5   HOH   HOH A . 
D 3 HOH   83  483 253 HOH   HOH A . 
D 3 HOH   84  484 371 HOH   HOH A . 
D 3 HOH   85  485 230 HOH   HOH A . 
D 3 HOH   86  486 451 HOH   HOH A . 
D 3 HOH   87  487 480 HOH   HOH A . 
D 3 HOH   88  488 425 HOH   HOH A . 
D 3 HOH   89  489 122 HOH   HOH A . 
D 3 HOH   90  490 383 HOH   HOH A . 
D 3 HOH   91  491 266 HOH   HOH A . 
D 3 HOH   92  492 35  HOH   HOH A . 
D 3 HOH   93  493 49  HOH   HOH A . 
D 3 HOH   94  494 467 HOH   HOH A . 
D 3 HOH   95  495 345 HOH   HOH A . 
D 3 HOH   96  496 168 HOH   HOH A . 
D 3 HOH   97  497 91  HOH   HOH A . 
D 3 HOH   98  498 532 HOH   HOH A . 
D 3 HOH   99  499 81  HOH   HOH A . 
D 3 HOH   100 500 270 HOH   HOH A . 
D 3 HOH   101 501 186 HOH   HOH A . 
D 3 HOH   102 502 92  HOH   HOH A . 
D 3 HOH   103 503 391 HOH   HOH A . 
D 3 HOH   104 504 428 HOH   HOH A . 
D 3 HOH   105 505 185 HOH   HOH A . 
D 3 HOH   106 506 34  HOH   HOH A . 
D 3 HOH   107 507 429 HOH   HOH A . 
D 3 HOH   108 508 382 HOH   HOH A . 
D 3 HOH   109 509 517 HOH   HOH A . 
D 3 HOH   110 510 440 HOH   HOH A . 
D 3 HOH   111 511 455 HOH   HOH A . 
D 3 HOH   112 512 501 HOH   HOH A . 
D 3 HOH   113 513 396 HOH   HOH A . 
D 3 HOH   114 514 272 HOH   HOH A . 
D 3 HOH   115 515 278 HOH   HOH A . 
D 3 HOH   116 516 3   HOH   HOH A . 
D 3 HOH   117 517 21  HOH   HOH A . 
D 3 HOH   118 518 413 HOH   HOH A . 
D 3 HOH   119 519 192 HOH   HOH A . 
D 3 HOH   120 520 384 HOH   HOH A . 
D 3 HOH   121 521 56  HOH   HOH A . 
D 3 HOH   122 522 118 HOH   HOH A . 
D 3 HOH   123 523 115 HOH   HOH A . 
D 3 HOH   124 524 295 HOH   HOH A . 
D 3 HOH   125 525 17  HOH   HOH A . 
D 3 HOH   126 526 29  HOH   HOH A . 
D 3 HOH   127 527 478 HOH   HOH A . 
D 3 HOH   128 528 433 HOH   HOH A . 
D 3 HOH   129 529 113 HOH   HOH A . 
D 3 HOH   130 530 330 HOH   HOH A . 
D 3 HOH   131 531 155 HOH   HOH A . 
D 3 HOH   132 532 184 HOH   HOH A . 
D 3 HOH   133 533 41  HOH   HOH A . 
D 3 HOH   134 534 47  HOH   HOH A . 
D 3 HOH   135 535 39  HOH   HOH A . 
D 3 HOH   136 536 59  HOH   HOH A . 
D 3 HOH   137 537 498 HOH   HOH A . 
D 3 HOH   138 538 486 HOH   HOH A . 
D 3 HOH   139 539 257 HOH   HOH A . 
D 3 HOH   140 540 300 HOH   HOH A . 
D 3 HOH   141 541 13  HOH   HOH A . 
D 3 HOH   142 542 538 HOH   HOH A . 
D 3 HOH   143 543 26  HOH   HOH A . 
D 3 HOH   144 544 353 HOH   HOH A . 
D 3 HOH   145 545 265 HOH   HOH A . 
D 3 HOH   146 546 58  HOH   HOH A . 
D 3 HOH   147 547 503 HOH   HOH A . 
D 3 HOH   148 548 288 HOH   HOH A . 
D 3 HOH   149 549 120 HOH   HOH A . 
D 3 HOH   150 550 69  HOH   HOH A . 
D 3 HOH   151 551 6   HOH   HOH A . 
D 3 HOH   152 552 439 HOH   HOH A . 
D 3 HOH   153 553 88  HOH   HOH A . 
D 3 HOH   154 554 309 HOH   HOH A . 
D 3 HOH   155 555 271 HOH   HOH A . 
D 3 HOH   156 556 366 HOH   HOH A . 
D 3 HOH   157 557 210 HOH   HOH A . 
D 3 HOH   158 558 74  HOH   HOH A . 
D 3 HOH   159 559 416 HOH   HOH A . 
D 3 HOH   160 560 132 HOH   HOH A . 
D 3 HOH   161 561 245 HOH   HOH A . 
D 3 HOH   162 562 12  HOH   HOH A . 
D 3 HOH   163 563 114 HOH   HOH A . 
D 3 HOH   164 564 342 HOH   HOH A . 
D 3 HOH   165 565 352 HOH   HOH A . 
D 3 HOH   166 566 491 HOH   HOH A . 
D 3 HOH   167 567 223 HOH   HOH A . 
D 3 HOH   168 568 458 HOH   HOH A . 
D 3 HOH   169 569 222 HOH   HOH A . 
D 3 HOH   170 570 195 HOH   HOH A . 
D 3 HOH   171 571 527 HOH   HOH A . 
D 3 HOH   172 572 76  HOH   HOH A . 
D 3 HOH   173 573 381 HOH   HOH A . 
D 3 HOH   174 574 176 HOH   HOH A . 
D 3 HOH   175 575 55  HOH   HOH A . 
D 3 HOH   176 576 375 HOH   HOH A . 
D 3 HOH   177 577 407 HOH   HOH A . 
D 3 HOH   178 578 398 HOH   HOH A . 
D 3 HOH   179 579 138 HOH   HOH A . 
D 3 HOH   180 580 441 HOH   HOH A . 
D 3 HOH   181 581 27  HOH   HOH A . 
D 3 HOH   182 582 148 HOH   HOH A . 
D 3 HOH   183 583 226 HOH   HOH A . 
D 3 HOH   184 584 189 HOH   HOH A . 
D 3 HOH   185 585 97  HOH   HOH A . 
D 3 HOH   186 586 444 HOH   HOH A . 
D 3 HOH   187 587 518 HOH   HOH A . 
D 3 HOH   188 588 123 HOH   HOH A . 
D 3 HOH   189 589 293 HOH   HOH A . 
D 3 HOH   190 590 200 HOH   HOH A . 
D 3 HOH   191 591 344 HOH   HOH A . 
D 3 HOH   192 592 15  HOH   HOH A . 
D 3 HOH   193 593 201 HOH   HOH A . 
D 3 HOH   194 594 514 HOH   HOH A . 
D 3 HOH   195 595 213 HOH   HOH A . 
D 3 HOH   196 596 515 HOH   HOH A . 
D 3 HOH   197 597 325 HOH   HOH A . 
D 3 HOH   198 598 536 HOH   HOH A . 
D 3 HOH   199 599 287 HOH   HOH A . 
D 3 HOH   200 600 447 HOH   HOH A . 
D 3 HOH   201 601 332 HOH   HOH A . 
D 3 HOH   202 602 481 HOH   HOH A . 
D 3 HOH   203 603 170 HOH   HOH A . 
D 3 HOH   204 604 508 HOH   HOH A . 
D 3 HOH   205 605 57  HOH   HOH A . 
D 3 HOH   206 606 489 HOH   HOH A . 
D 3 HOH   207 607 316 HOH   HOH A . 
D 3 HOH   208 608 321 HOH   HOH A . 
D 3 HOH   209 609 136 HOH   HOH A . 
D 3 HOH   210 610 142 HOH   HOH A . 
D 3 HOH   211 611 313 HOH   HOH A . 
D 3 HOH   212 612 292 HOH   HOH A . 
D 3 HOH   213 613 412 HOH   HOH A . 
D 3 HOH   214 614 392 HOH   HOH A . 
D 3 HOH   215 615 477 HOH   HOH A . 
D 3 HOH   216 616 373 HOH   HOH A . 
D 3 HOH   217 617 488 HOH   HOH A . 
D 3 HOH   218 618 367 HOH   HOH A . 
D 3 HOH   219 619 385 HOH   HOH A . 
D 3 HOH   220 620 318 HOH   HOH A . 
D 3 HOH   221 621 454 HOH   HOH A . 
D 3 HOH   222 622 85  HOH   HOH A . 
D 3 HOH   223 623 234 HOH   HOH A . 
D 3 HOH   224 624 243 HOH   HOH A . 
D 3 HOH   225 625 452 HOH   HOH A . 
D 3 HOH   226 626 531 HOH   HOH A . 
D 3 HOH   227 627 331 HOH   HOH A . 
D 3 HOH   228 628 475 HOH   HOH A . 
D 3 HOH   229 629 470 HOH   HOH A . 
D 3 HOH   230 630 482 HOH   HOH A . 
D 3 HOH   231 631 465 HOH   HOH A . 
D 3 HOH   232 632 462 HOH   HOH A . 
D 3 HOH   233 633 408 HOH   HOH A . 
D 3 HOH   234 634 209 HOH   HOH A . 
D 3 HOH   235 635 500 HOH   HOH A . 
D 3 HOH   236 636 495 HOH   HOH A . 
D 3 HOH   237 637 448 HOH   HOH A . 
D 3 HOH   238 638 280 HOH   HOH A . 
D 3 HOH   239 639 336 HOH   HOH A . 
D 3 HOH   240 640 378 HOH   HOH A . 
D 3 HOH   241 641 343 HOH   HOH A . 
D 3 HOH   242 642 494 HOH   HOH A . 
D 3 HOH   243 643 461 HOH   HOH A . 
D 3 HOH   244 644 146 HOH   HOH A . 
D 3 HOH   245 645 351 HOH   HOH A . 
D 3 HOH   246 646 499 HOH   HOH A . 
D 3 HOH   247 647 279 HOH   HOH A . 
D 3 HOH   248 648 162 HOH   HOH A . 
D 3 HOH   249 649 327 HOH   HOH A . 
D 3 HOH   250 650 248 HOH   HOH A . 
D 3 HOH   251 651 319 HOH   HOH A . 
D 3 HOH   252 652 315 HOH   HOH A . 
D 3 HOH   253 653 178 HOH   HOH A . 
D 3 HOH   254 654 310 HOH   HOH A . 
D 3 HOH   255 655 496 HOH   HOH A . 
D 3 HOH   256 656 284 HOH   HOH A . 
D 3 HOH   257 657 511 HOH   HOH A . 
D 3 HOH   258 658 328 HOH   HOH A . 
D 3 HOH   259 659 227 HOH   HOH A . 
D 3 HOH   260 660 519 HOH   HOH A . 
D 3 HOH   261 661 469 HOH   HOH A . 
D 3 HOH   262 662 490 HOH   HOH A . 
D 3 HOH   263 663 521 HOH   HOH A . 
D 3 HOH   264 664 374 HOH   HOH A . 
E 3 HOH   1   501 438 HOH   HOH B . 
E 3 HOH   2   502 161 HOH   HOH B . 
E 3 HOH   3   503 96  HOH   HOH B . 
E 3 HOH   4   504 150 HOH   HOH B . 
E 3 HOH   5   505 156 HOH   HOH B . 
E 3 HOH   6   506 537 HOH   HOH B . 
E 3 HOH   7   507 100 HOH   HOH B . 
E 3 HOH   8   508 506 HOH   HOH B . 
E 3 HOH   9   509 379 HOH   HOH B . 
E 3 HOH   10  510 104 HOH   HOH B . 
E 3 HOH   11  511 218 HOH   HOH B . 
E 3 HOH   12  512 241 HOH   HOH B . 
E 3 HOH   13  513 66  HOH   HOH B . 
E 3 HOH   14  514 38  HOH   HOH B . 
E 3 HOH   15  515 42  HOH   HOH B . 
E 3 HOH   16  516 197 HOH   HOH B . 
E 3 HOH   17  517 528 HOH   HOH B . 
E 3 HOH   18  518 471 HOH   HOH B . 
E 3 HOH   19  519 163 HOH   HOH B . 
E 3 HOH   20  520 131 HOH   HOH B . 
E 3 HOH   21  521 160 HOH   HOH B . 
E 3 HOH   22  522 326 HOH   HOH B . 
E 3 HOH   23  523 393 HOH   HOH B . 
E 3 HOH   24  524 73  HOH   HOH B . 
E 3 HOH   25  525 264 HOH   HOH B . 
E 3 HOH   26  526 72  HOH   HOH B . 
E 3 HOH   27  527 509 HOH   HOH B . 
E 3 HOH   28  528 255 HOH   HOH B . 
E 3 HOH   29  529 349 HOH   HOH B . 
E 3 HOH   30  530 423 HOH   HOH B . 
E 3 HOH   31  531 357 HOH   HOH B . 
E 3 HOH   32  532 103 HOH   HOH B . 
E 3 HOH   33  533 390 HOH   HOH B . 
E 3 HOH   34  534 206 HOH   HOH B . 
E 3 HOH   35  535 359 HOH   HOH B . 
E 3 HOH   36  536 93  HOH   HOH B . 
E 3 HOH   37  537 14  HOH   HOH B . 
E 3 HOH   38  538 388 HOH   HOH B . 
E 3 HOH   39  539 110 HOH   HOH B . 
E 3 HOH   40  540 261 HOH   HOH B . 
E 3 HOH   41  541 20  HOH   HOH B . 
E 3 HOH   42  542 217 HOH   HOH B . 
E 3 HOH   43  543 51  HOH   HOH B . 
E 3 HOH   44  544 173 HOH   HOH B . 
E 3 HOH   45  545 133 HOH   HOH B . 
E 3 HOH   46  546 137 HOH   HOH B . 
E 3 HOH   47  547 33  HOH   HOH B . 
E 3 HOH   48  548 67  HOH   HOH B . 
E 3 HOH   49  549 445 HOH   HOH B . 
E 3 HOH   50  550 410 HOH   HOH B . 
E 3 HOH   51  551 214 HOH   HOH B . 
E 3 HOH   52  552 507 HOH   HOH B . 
E 3 HOH   53  553 80  HOH   HOH B . 
E 3 HOH   54  554 274 HOH   HOH B . 
E 3 HOH   55  555 443 HOH   HOH B . 
E 3 HOH   56  556 523 HOH   HOH B . 
E 3 HOH   57  557 333 HOH   HOH B . 
E 3 HOH   58  558 535 HOH   HOH B . 
E 3 HOH   59  559 434 HOH   HOH B . 
E 3 HOH   60  560 159 HOH   HOH B . 
E 3 HOH   61  561 529 HOH   HOH B . 
E 3 HOH   62  562 244 HOH   HOH B . 
E 3 HOH   63  563 198 HOH   HOH B . 
E 3 HOH   64  564 193 HOH   HOH B . 
E 3 HOH   65  565 105 HOH   HOH B . 
E 3 HOH   66  566 179 HOH   HOH B . 
E 3 HOH   67  567 411 HOH   HOH B . 
E 3 HOH   68  568 79  HOH   HOH B . 
E 3 HOH   69  569 259 HOH   HOH B . 
E 3 HOH   70  570 126 HOH   HOH B . 
E 3 HOH   71  571 364 HOH   HOH B . 
E 3 HOH   72  572 400 HOH   HOH B . 
E 3 HOH   73  573 48  HOH   HOH B . 
E 3 HOH   74  574 337 HOH   HOH B . 
E 3 HOH   75  575 446 HOH   HOH B . 
E 3 HOH   76  576 143 HOH   HOH B . 
E 3 HOH   77  577 2   HOH   HOH B . 
E 3 HOH   78  578 380 HOH   HOH B . 
E 3 HOH   79  579 387 HOH   HOH B . 
E 3 HOH   80  580 19  HOH   HOH B . 
E 3 HOH   81  581 426 HOH   HOH B . 
E 3 HOH   82  582 512 HOH   HOH B . 
E 3 HOH   83  583 95  HOH   HOH B . 
E 3 HOH   84  584 182 HOH   HOH B . 
E 3 HOH   85  585 147 HOH   HOH B . 
E 3 HOH   86  586 40  HOH   HOH B . 
E 3 HOH   87  587 174 HOH   HOH B . 
E 3 HOH   88  588 87  HOH   HOH B . 
E 3 HOH   89  589 334 HOH   HOH B . 
E 3 HOH   90  590 16  HOH   HOH B . 
E 3 HOH   91  591 421 HOH   HOH B . 
E 3 HOH   92  592 361 HOH   HOH B . 
E 3 HOH   93  593 152 HOH   HOH B . 
E 3 HOH   94  594 8   HOH   HOH B . 
E 3 HOH   95  595 11  HOH   HOH B . 
E 3 HOH   96  596 203 HOH   HOH B . 
E 3 HOH   97  597 82  HOH   HOH B . 
E 3 HOH   98  598 476 HOH   HOH B . 
E 3 HOH   99  599 487 HOH   HOH B . 
E 3 HOH   100 600 60  HOH   HOH B . 
E 3 HOH   101 601 37  HOH   HOH B . 
E 3 HOH   102 602 229 HOH   HOH B . 
E 3 HOH   103 603 196 HOH   HOH B . 
E 3 HOH   104 604 98  HOH   HOH B . 
E 3 HOH   105 605 235 HOH   HOH B . 
E 3 HOH   106 606 215 HOH   HOH B . 
E 3 HOH   107 607 84  HOH   HOH B . 
E 3 HOH   108 608 106 HOH   HOH B . 
E 3 HOH   109 609 303 HOH   HOH B . 
E 3 HOH   110 610 151 HOH   HOH B . 
E 3 HOH   111 611 262 HOH   HOH B . 
E 3 HOH   112 612 86  HOH   HOH B . 
E 3 HOH   113 613 324 HOH   HOH B . 
E 3 HOH   114 614 298 HOH   HOH B . 
E 3 HOH   115 615 460 HOH   HOH B . 
E 3 HOH   116 616 497 HOH   HOH B . 
E 3 HOH   117 617 23  HOH   HOH B . 
E 3 HOH   118 618 305 HOH   HOH B . 
E 3 HOH   119 619 394 HOH   HOH B . 
E 3 HOH   120 620 119 HOH   HOH B . 
E 3 HOH   121 621 32  HOH   HOH B . 
E 3 HOH   122 622 504 HOH   HOH B . 
E 3 HOH   123 623 472 HOH   HOH B . 
E 3 HOH   124 624 25  HOH   HOH B . 
E 3 HOH   125 625 28  HOH   HOH B . 
E 3 HOH   126 626 422 HOH   HOH B . 
E 3 HOH   127 627 46  HOH   HOH B . 
E 3 HOH   128 628 346 HOH   HOH B . 
E 3 HOH   129 629 70  HOH   HOH B . 
E 3 HOH   130 630 225 HOH   HOH B . 
E 3 HOH   131 631 335 HOH   HOH B . 
E 3 HOH   132 632 307 HOH   HOH B . 
E 3 HOH   133 633 232 HOH   HOH B . 
E 3 HOH   134 634 52  HOH   HOH B . 
E 3 HOH   135 635 194 HOH   HOH B . 
E 3 HOH   136 636 311 HOH   HOH B . 
E 3 HOH   137 637 233 HOH   HOH B . 
E 3 HOH   138 638 145 HOH   HOH B . 
E 3 HOH   139 639 141 HOH   HOH B . 
E 3 HOH   140 640 54  HOH   HOH B . 
E 3 HOH   141 641 166 HOH   HOH B . 
E 3 HOH   142 642 191 HOH   HOH B . 
E 3 HOH   143 643 164 HOH   HOH B . 
E 3 HOH   144 644 116 HOH   HOH B . 
E 3 HOH   145 645 240 HOH   HOH B . 
E 3 HOH   146 646 124 HOH   HOH B . 
E 3 HOH   147 647 187 HOH   HOH B . 
E 3 HOH   148 648 484 HOH   HOH B . 
E 3 HOH   149 649 437 HOH   HOH B . 
E 3 HOH   150 650 419 HOH   HOH B . 
E 3 HOH   151 651 524 HOH   HOH B . 
E 3 HOH   152 652 31  HOH   HOH B . 
E 3 HOH   153 653 153 HOH   HOH B . 
E 3 HOH   154 654 306 HOH   HOH B . 
E 3 HOH   155 655 53  HOH   HOH B . 
E 3 HOH   156 656 171 HOH   HOH B . 
E 3 HOH   157 657 360 HOH   HOH B . 
E 3 HOH   158 658 249 HOH   HOH B . 
E 3 HOH   159 659 294 HOH   HOH B . 
E 3 HOH   160 660 468 HOH   HOH B . 
E 3 HOH   161 661 456 HOH   HOH B . 
E 3 HOH   162 662 299 HOH   HOH B . 
E 3 HOH   163 663 109 HOH   HOH B . 
E 3 HOH   164 664 90  HOH   HOH B . 
E 3 HOH   165 665 277 HOH   HOH B . 
E 3 HOH   166 666 256 HOH   HOH B . 
E 3 HOH   167 667 154 HOH   HOH B . 
E 3 HOH   168 668 356 HOH   HOH B . 
E 3 HOH   169 669 220 HOH   HOH B . 
E 3 HOH   170 670 473 HOH   HOH B . 
E 3 HOH   171 671 101 HOH   HOH B . 
E 3 HOH   172 672 317 HOH   HOH B . 
E 3 HOH   173 673 442 HOH   HOH B . 
E 3 HOH   174 674 297 HOH   HOH B . 
E 3 HOH   175 675 30  HOH   HOH B . 
E 3 HOH   176 676 302 HOH   HOH B . 
E 3 HOH   177 677 399 HOH   HOH B . 
E 3 HOH   178 678 102 HOH   HOH B . 
E 3 HOH   179 679 369 HOH   HOH B . 
E 3 HOH   180 680 520 HOH   HOH B . 
E 3 HOH   181 681 172 HOH   HOH B . 
E 3 HOH   182 682 275 HOH   HOH B . 
E 3 HOH   183 683 289 HOH   HOH B . 
E 3 HOH   184 684 242 HOH   HOH B . 
E 3 HOH   185 685 417 HOH   HOH B . 
E 3 HOH   186 686 45  HOH   HOH B . 
E 3 HOH   187 687 314 HOH   HOH B . 
E 3 HOH   188 688 405 HOH   HOH B . 
E 3 HOH   189 689 258 HOH   HOH B . 
E 3 HOH   190 690 483 HOH   HOH B . 
E 3 HOH   191 691 432 HOH   HOH B . 
E 3 HOH   192 692 181 HOH   HOH B . 
E 3 HOH   193 693 10  HOH   HOH B . 
E 3 HOH   194 694 252 HOH   HOH B . 
E 3 HOH   195 695 237 HOH   HOH B . 
E 3 HOH   196 696 358 HOH   HOH B . 
E 3 HOH   197 697 502 HOH   HOH B . 
E 3 HOH   198 698 71  HOH   HOH B . 
E 3 HOH   199 699 534 HOH   HOH B . 
E 3 HOH   200 700 282 HOH   HOH B . 
E 3 HOH   201 701 135 HOH   HOH B . 
E 3 HOH   202 702 525 HOH   HOH B . 
E 3 HOH   203 703 167 HOH   HOH B . 
E 3 HOH   204 704 246 HOH   HOH B . 
E 3 HOH   205 705 402 HOH   HOH B . 
E 3 HOH   206 706 347 HOH   HOH B . 
E 3 HOH   207 707 254 HOH   HOH B . 
E 3 HOH   208 708 348 HOH   HOH B . 
E 3 HOH   209 709 228 HOH   HOH B . 
E 3 HOH   210 710 75  HOH   HOH B . 
E 3 HOH   211 711 395 HOH   HOH B . 
E 3 HOH   212 712 247 HOH   HOH B . 
E 3 HOH   213 713 308 HOH   HOH B . 
E 3 HOH   214 714 427 HOH   HOH B . 
E 3 HOH   215 715 435 HOH   HOH B . 
E 3 HOH   216 716 530 HOH   HOH B . 
E 3 HOH   217 717 149 HOH   HOH B . 
E 3 HOH   218 718 269 HOH   HOH B . 
E 3 HOH   219 719 251 HOH   HOH B . 
E 3 HOH   220 720 285 HOH   HOH B . 
E 3 HOH   221 721 205 HOH   HOH B . 
E 3 HOH   222 722 403 HOH   HOH B . 
E 3 HOH   223 723 117 HOH   HOH B . 
E 3 HOH   224 724 236 HOH   HOH B . 
E 3 HOH   225 725 281 HOH   HOH B . 
E 3 HOH   226 726 350 HOH   HOH B . 
E 3 HOH   227 727 386 HOH   HOH B . 
E 3 HOH   228 728 415 HOH   HOH B . 
E 3 HOH   229 729 221 HOH   HOH B . 
E 3 HOH   230 730 339 HOH   HOH B . 
E 3 HOH   231 731 516 HOH   HOH B . 
E 3 HOH   232 732 479 HOH   HOH B . 
E 3 HOH   233 733 354 HOH   HOH B . 
E 3 HOH   234 734 231 HOH   HOH B . 
E 3 HOH   235 735 457 HOH   HOH B . 
E 3 HOH   236 736 340 HOH   HOH B . 
E 3 HOH   237 737 363 HOH   HOH B . 
E 3 HOH   238 738 99  HOH   HOH B . 
E 3 HOH   239 739 463 HOH   HOH B . 
E 3 HOH   240 740 492 HOH   HOH B . 
E 3 HOH   241 741 459 HOH   HOH B . 
E 3 HOH   242 742 370 HOH   HOH B . 
E 3 HOH   243 743 268 HOH   HOH B . 
E 3 HOH   244 744 397 HOH   HOH B . 
E 3 HOH   245 745 365 HOH   HOH B . 
E 3 HOH   246 746 323 HOH   HOH B . 
E 3 HOH   247 747 505 HOH   HOH B . 
E 3 HOH   248 748 533 HOH   HOH B . 
E 3 HOH   249 749 219 HOH   HOH B . 
E 3 HOH   250 750 130 HOH   HOH B . 
E 3 HOH   251 751 263 HOH   HOH B . 
E 3 HOH   252 752 513 HOH   HOH B . 
E 3 HOH   253 753 134 HOH   HOH B . 
E 3 HOH   254 754 404 HOH   HOH B . 
E 3 HOH   255 755 474 HOH   HOH B . 
E 3 HOH   256 756 372 HOH   HOH B . 
E 3 HOH   257 757 89  HOH   HOH B . 
E 3 HOH   258 758 329 HOH   HOH B . 
E 3 HOH   259 759 449 HOH   HOH B . 
E 3 HOH   260 760 368 HOH   HOH B . 
E 3 HOH   261 761 526 HOH   HOH B . 
E 3 HOH   262 762 183 HOH   HOH B . 
E 3 HOH   263 763 157 HOH   HOH B . 
E 3 HOH   264 764 401 HOH   HOH B . 
E 3 HOH   265 765 466 HOH   HOH B . 
E 3 HOH   266 766 430 HOH   HOH B . 
E 3 HOH   267 767 377 HOH   HOH B . 
E 3 HOH   268 768 406 HOH   HOH B . 
E 3 HOH   269 769 239 HOH   HOH B . 
E 3 HOH   270 770 139 HOH   HOH B . 
E 3 HOH   271 771 267 HOH   HOH B . 
E 3 HOH   272 772 409 HOH   HOH B . 
E 3 HOH   273 773 464 HOH   HOH B . 
E 3 HOH   274 774 414 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.1_4122 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YST 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     48.850 
_cell.length_a_esd                 ? 
_cell.length_b                     113.441 
_cell.length_b_esd                 ? 
_cell.length_c                     134.189 
_cell.length_c_esd                 ? 
_cell.volume                       743628.414 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YST 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YST 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.15 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.80 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '27% PEG 4000, 0.09 M Tris-HCl, pH 8.0, 0.18 M magnesium chloride, 3% 1,6-Hexanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-6000HE' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-03-04 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.542 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.542 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          14.84 
_reflns.entry_id                                       8YST 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.9 
_reflns.d_resolution_low                               21.51 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     59260 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.25 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          21.12 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.9 
_reflns_shell.d_res_low                                     1.968 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           5.66 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5647 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.93 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.02 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YST 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             21.51 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     59256 
_refine.ls_number_reflns_R_free                  2948 
_refine.ls_number_reflns_R_work                  56308 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.35 
_refine.ls_percent_reflns_R_free                 4.98 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1951 
_refine.ls_R_factor_R_free                       0.2297 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1933 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.3894 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1995 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        21.51 
_refine_hist.number_atoms_solvent             538 
_refine_hist.number_atoms_total               6272 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5718 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         16 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0026 ? 5844 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.6249 ? 7948 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0423 ? 936  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0054 ? 1024 ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.5374 ? 805  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.93  . . 125 2561 94.64  . . . . 0.2248 . . . . . . . . . . . 0.2637 
'X-RAY DIFFRACTION' 1.93 1.96  . . 124 2563 97.07  . . . . 0.2151 . . . . . . . . . . . 0.2764 
'X-RAY DIFFRACTION' 1.96 2.00  . . 139 2641 100.00 . . . . 0.2148 . . . . . . . . . . . 0.2901 
'X-RAY DIFFRACTION' 2.00 2.04  . . 153 2674 99.68  . . . . 0.2181 . . . . . . . . . . . 0.2572 
'X-RAY DIFFRACTION' 2.04 2.08  . . 135 2626 100.00 . . . . 0.2063 . . . . . . . . . . . 0.2387 
'X-RAY DIFFRACTION' 2.08 2.13  . . 149 2693 99.86  . . . . 0.2135 . . . . . . . . . . . 0.2362 
'X-RAY DIFFRACTION' 2.13 2.17  . . 132 2641 100.00 . . . . 0.2112 . . . . . . . . . . . 0.2671 
'X-RAY DIFFRACTION' 2.17 2.23  . . 128 2704 100.00 . . . . 0.2045 . . . . . . . . . . . 0.2547 
'X-RAY DIFFRACTION' 2.23 2.29  . . 149 2655 100.00 . . . . 0.2054 . . . . . . . . . . . 0.2593 
'X-RAY DIFFRACTION' 2.29 2.36  . . 137 2660 99.96  . . . . 0.2082 . . . . . . . . . . . 0.2352 
'X-RAY DIFFRACTION' 2.36 2.43  . . 149 2699 100.00 . . . . 0.1996 . . . . . . . . . . . 0.2484 
'X-RAY DIFFRACTION' 2.43 2.52  . . 143 2665 100.00 . . . . 0.1975 . . . . . . . . . . . 0.2476 
'X-RAY DIFFRACTION' 2.52 2.62  . . 135 2671 99.93  . . . . 0.2048 . . . . . . . . . . . 0.2443 
'X-RAY DIFFRACTION' 2.62 2.74  . . 152 2701 100.00 . . . . 0.2031 . . . . . . . . . . . 0.2611 
'X-RAY DIFFRACTION' 2.74 2.88  . . 145 2709 99.96  . . . . 0.2063 . . . . . . . . . . . 0.2194 
'X-RAY DIFFRACTION' 2.88 3.06  . . 125 2702 99.86  . . . . 0.1953 . . . . . . . . . . . 0.2082 
'X-RAY DIFFRACTION' 3.06 3.30  . . 147 2691 99.72  . . . . 0.1934 . . . . . . . . . . . 0.2105 
'X-RAY DIFFRACTION' 3.30 3.63  . . 142 2721 99.44  . . . . 0.1771 . . . . . . . . . . . 0.1871 
'X-RAY DIFFRACTION' 3.63 4.15  . . 143 2731 99.24  . . . . 0.1733 . . . . . . . . . . . 0.2211 
'X-RAY DIFFRACTION' 4.15 5.22  . . 139 2740 98.73  . . . . 0.1571 . . . . . . . . . . . 0.1899 
'X-RAY DIFFRACTION' 5.22 21.51 . . 157 2860 98.31  . . . . 0.1783 . . . . . . . . . . . 0.2179 
# 
_struct.entry_id                     8YST 
_struct.title                        'Structure of CylI in complex with beta-ketoacyl-SNAC substrate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YST 
_struct_keywords.text            'cyanobacteria, cylindrocyclophane, type III PKS, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    K7SIG4_9NOST 
_struct_ref.pdbx_db_accession          K7SIG4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MTYIVSTSTAFPENYYPQTVLAAALRRFFTVMELDFDLEQIDRFFTNVKIDGRYFALPLDSLLDPPTWGVSISRGLENSL
NLAETAITKLLEKTNVQPQDISLLASVSMTPAIPSLDGRLMNRIPFSSTLKRLPMNGVGCMGGAFGISRVADYLKAHPKE
AAILFAVEISSALWQGSLQANLTSLIRRLPENPSLYSEIIMDIITAALFADGCGAVLMVGKEHPLAKSGLPQVIDNRSFL
VPNTVELMGLDVVDNGFRNILRPEVSDALKQGLRPLINGLLADNNIESENLYRWIVHPGGPKVIDTVEAEFGLDSQTLQL
SRDTLAEVGNISSATVLYMLDKVLSEEQSPPDSYGLIVAMGPGLAQEAILLKW
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YST A 22 ? 394 ? K7SIG4 1 ? 373 ? 1 373 
2 1 8YST B 22 ? 394 ? K7SIG4 1 ? 373 ? 1 373 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YST MET A 1  ? UNP K7SIG4 ? ? 'initiating methionine' -20 1  
1 8YST GLY A 2  ? UNP K7SIG4 ? ? 'expression tag'        -19 2  
1 8YST SER A 3  ? UNP K7SIG4 ? ? 'expression tag'        -18 3  
1 8YST SER A 4  ? UNP K7SIG4 ? ? 'expression tag'        -17 4  
1 8YST HIS A 5  ? UNP K7SIG4 ? ? 'expression tag'        -16 5  
1 8YST HIS A 6  ? UNP K7SIG4 ? ? 'expression tag'        -15 6  
1 8YST HIS A 7  ? UNP K7SIG4 ? ? 'expression tag'        -14 7  
1 8YST HIS A 8  ? UNP K7SIG4 ? ? 'expression tag'        -13 8  
1 8YST HIS A 9  ? UNP K7SIG4 ? ? 'expression tag'        -12 9  
1 8YST HIS A 10 ? UNP K7SIG4 ? ? 'expression tag'        -11 10 
1 8YST SER A 11 ? UNP K7SIG4 ? ? 'expression tag'        -10 11 
1 8YST SER A 12 ? UNP K7SIG4 ? ? 'expression tag'        -9  12 
1 8YST GLY A 13 ? UNP K7SIG4 ? ? 'expression tag'        -8  13 
1 8YST GLU A 14 ? UNP K7SIG4 ? ? 'expression tag'        -7  14 
1 8YST ASN A 15 ? UNP K7SIG4 ? ? 'expression tag'        -6  15 
1 8YST LEU A 16 ? UNP K7SIG4 ? ? 'expression tag'        -5  16 
1 8YST TYR A 17 ? UNP K7SIG4 ? ? 'expression tag'        -4  17 
1 8YST PHE A 18 ? UNP K7SIG4 ? ? 'expression tag'        -3  18 
1 8YST GLN A 19 ? UNP K7SIG4 ? ? 'expression tag'        -2  19 
1 8YST GLY A 20 ? UNP K7SIG4 ? ? 'expression tag'        -1  20 
1 8YST HIS A 21 ? UNP K7SIG4 ? ? 'expression tag'        0   21 
2 8YST MET B 1  ? UNP K7SIG4 ? ? 'initiating methionine' -20 22 
2 8YST GLY B 2  ? UNP K7SIG4 ? ? 'expression tag'        -19 23 
2 8YST SER B 3  ? UNP K7SIG4 ? ? 'expression tag'        -18 24 
2 8YST SER B 4  ? UNP K7SIG4 ? ? 'expression tag'        -17 25 
2 8YST HIS B 5  ? UNP K7SIG4 ? ? 'expression tag'        -16 26 
2 8YST HIS B 6  ? UNP K7SIG4 ? ? 'expression tag'        -15 27 
2 8YST HIS B 7  ? UNP K7SIG4 ? ? 'expression tag'        -14 28 
2 8YST HIS B 8  ? UNP K7SIG4 ? ? 'expression tag'        -13 29 
2 8YST HIS B 9  ? UNP K7SIG4 ? ? 'expression tag'        -12 30 
2 8YST HIS B 10 ? UNP K7SIG4 ? ? 'expression tag'        -11 31 
2 8YST SER B 11 ? UNP K7SIG4 ? ? 'expression tag'        -10 32 
2 8YST SER B 12 ? UNP K7SIG4 ? ? 'expression tag'        -9  33 
2 8YST GLY B 13 ? UNP K7SIG4 ? ? 'expression tag'        -8  34 
2 8YST GLU B 14 ? UNP K7SIG4 ? ? 'expression tag'        -7  35 
2 8YST ASN B 15 ? UNP K7SIG4 ? ? 'expression tag'        -6  36 
2 8YST LEU B 16 ? UNP K7SIG4 ? ? 'expression tag'        -5  37 
2 8YST TYR B 17 ? UNP K7SIG4 ? ? 'expression tag'        -4  38 
2 8YST PHE B 18 ? UNP K7SIG4 ? ? 'expression tag'        -3  39 
2 8YST GLN B 19 ? UNP K7SIG4 ? ? 'expression tag'        -2  40 
2 8YST GLY B 20 ? UNP K7SIG4 ? ? 'expression tag'        -1  41 
2 8YST HIS B 21 ? UNP K7SIG4 ? ? 'expression tag'        0   42 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4190  ? 
1 MORE         -28   ? 
1 'SSA (A^2)'  25970 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'gel filtration'             ? 
2 1 'equilibrium centrifugation' ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 39  ? MET A 53  ? GLN A 18  MET A 32  1 ? 15 
HELX_P HELX_P2  AA2 ASP A 58  ? VAL A 69  ? ASP A 37  VAL A 48  1 ? 12 
HELX_P HELX_P3  AA3 THR A 88  ? ASN A 116 ? THR A 67  ASN A 95  1 ? 29 
HELX_P HELX_P4  AA4 GLN A 118 ? ILE A 122 ? GLN A 97  ILE A 101 5 ? 5  
HELX_P HELX_P5  AA5 SER A 136 ? MET A 142 ? SER A 115 MET A 121 1 ? 7  
HELX_P HELX_P6  AA6 VAL A 159 ? CYS A 161 ? VAL A 138 CYS A 140 5 ? 3  
HELX_P HELX_P7  AA7 MET A 162 ? HIS A 178 ? MET A 141 HIS A 157 1 ? 17 
HELX_P HELX_P8  AA8 SER A 192 ? GLN A 196 ? SER A 171 GLN A 175 5 ? 5  
HELX_P HELX_P9  AA9 GLY A 197 ? ARG A 209 ? GLY A 176 ARG A 188 1 ? 13 
HELX_P HELX_P10 AB1 ASN A 213 ? SER A 215 ? ASN A 192 SER A 194 5 ? 3  
HELX_P HELX_P11 AB2 LEU A 216 ? PHE A 230 ? LEU A 195 PHE A 209 1 ? 15 
HELX_P HELX_P12 AB3 THR A 265 ? GLU A 267 ? THR A 244 GLU A 246 5 ? 3  
HELX_P HELX_P13 AB4 GLU A 285 ? ASP A 304 ? GLU A 264 ASP A 283 1 ? 20 
HELX_P HELX_P14 AB5 GLU A 308 ? GLU A 310 ? GLU A 287 GLU A 289 5 ? 3  
HELX_P HELX_P15 AB6 GLY A 321 ? PHE A 332 ? GLY A 300 PHE A 311 1 ? 12 
HELX_P HELX_P16 AB7 LEU A 339 ? GLY A 350 ? LEU A 318 GLY A 329 1 ? 12 
HELX_P HELX_P17 AB8 ILE A 352 ? SER A 354 ? ILE A 331 SER A 333 5 ? 3  
HELX_P HELX_P18 AB9 ALA A 355 ? GLU A 368 ? ALA A 334 GLU A 347 1 ? 14 
HELX_P HELX_P19 AC1 GLN B 39  ? MET B 53  ? GLN B 18  MET B 32  1 ? 15 
HELX_P HELX_P20 AC2 LEU B 59  ? VAL B 69  ? LEU B 38  VAL B 48  1 ? 11 
HELX_P HELX_P21 AC3 LEU B 80  ? LEU B 84  ? LEU B 59  LEU B 63  5 ? 5  
HELX_P HELX_P22 AC4 THR B 88  ? ASN B 116 ? THR B 67  ASN B 95  1 ? 29 
HELX_P HELX_P23 AC5 GLN B 118 ? ILE B 122 ? GLN B 97  ILE B 101 5 ? 5  
HELX_P HELX_P24 AC6 SER B 136 ? MET B 142 ? SER B 115 MET B 121 1 ? 7  
HELX_P HELX_P25 AC7 VAL B 159 ? CYS B 161 ? VAL B 138 CYS B 140 5 ? 3  
HELX_P HELX_P26 AC8 MET B 162 ? ALA B 177 ? MET B 141 ALA B 156 1 ? 16 
HELX_P HELX_P27 AC9 SER B 192 ? GLN B 196 ? SER B 171 GLN B 175 5 ? 5  
HELX_P HELX_P28 AD1 GLY B 197 ? LEU B 210 ? GLY B 176 LEU B 189 1 ? 14 
HELX_P HELX_P29 AD2 PRO B 211 ? SER B 215 ? PRO B 190 SER B 194 5 ? 5  
HELX_P HELX_P30 AD3 LEU B 216 ? PHE B 230 ? LEU B 195 PHE B 209 1 ? 15 
HELX_P HELX_P31 AD4 THR B 265 ? GLU B 267 ? THR B 244 GLU B 246 5 ? 3  
HELX_P HELX_P32 AD5 GLU B 285 ? ASN B 305 ? GLU B 264 ASN B 284 1 ? 21 
HELX_P HELX_P33 AD6 GLU B 308 ? LEU B 312 ? GLU B 287 LEU B 291 5 ? 5  
HELX_P HELX_P34 AD7 GLY B 321 ? PHE B 332 ? GLY B 300 PHE B 311 1 ? 12 
HELX_P HELX_P35 AD8 LEU B 339 ? GLY B 350 ? LEU B 318 GLY B 329 1 ? 12 
HELX_P HELX_P36 AD9 ILE B 352 ? SER B 354 ? ILE B 331 SER B 333 5 ? 3  
HELX_P HELX_P37 AE1 ALA B 355 ? SER B 366 ? ALA B 334 SER B 345 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ILE 134 A . ? ILE 113 A PRO 135 A ? PRO 114 A 1 6.52   
2 GLY 384 A . ? GLY 363 A LEU 385 A ? LEU 364 A 1 -18.71 
3 ILE 134 B . ? ILE 113 B PRO 135 B ? PRO 114 B 1 6.51   
4 GLY 384 B . ? GLY 363 B LEU 385 B ? LEU 364 B 1 24.64  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 9 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 9 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA1 8 9 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? parallel      
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA4 7 8 ? anti-parallel 
AA4 8 9 ? parallel      
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LYS A 152 ? MET A 156 ? LYS A 131 MET A 135 
AA1 2 LEU A 124 ? VAL A 128 ? LEU A 103 VAL A 107 
AA1 3 ALA A 182 ? ILE A 190 ? ALA A 161 ILE A 169 
AA1 4 ASP A 232 ? VAL A 240 ? ASP A 211 VAL A 219 
AA1 5 THR A 23  ? ALA A 31  ? THR A 2   ALA A 10  
AA1 6 GLN A 253 ? LEU A 261 ? GLN A 232 LEU A 240 
AA1 7 ALA A 386 ? LYS A 393 ? ALA A 365 LYS A 372 
AA1 8 TYR A 375 ? GLY A 382 ? TYR A 354 GLY A 361 
AA1 9 LEU A 312 ? VAL A 317 ? LEU A 291 VAL A 296 
AA2 1 TYR A 36  ? PRO A 38  ? TYR A 15  PRO A 17  
AA2 2 GLY A 73  ? TYR A 75  ? GLY A 52  TYR A 54  
AA3 1 MET A 269 ? ASP A 272 ? MET A 248 ASP A 251 
AA3 2 ARG A 279 ? LEU A 282 ? ARG A 258 LEU A 261 
AA4 1 LYS B 152 ? MET B 156 ? LYS B 131 MET B 135 
AA4 2 LEU B 124 ? VAL B 128 ? LEU B 103 VAL B 107 
AA4 3 ALA B 182 ? ILE B 190 ? ALA B 161 ILE B 169 
AA4 4 ASP B 232 ? VAL B 240 ? ASP B 211 VAL B 219 
AA4 5 THR B 23  ? ALA B 31  ? THR B 2   ALA B 10  
AA4 6 GLN B 253 ? LEU B 261 ? GLN B 232 LEU B 240 
AA4 7 ALA B 386 ? LYS B 393 ? ALA B 365 LYS B 372 
AA4 8 TYR B 375 ? GLY B 382 ? TYR B 354 GLY B 361 
AA4 9 ARG B 314 ? VAL B 317 ? ARG B 293 VAL B 296 
AA5 1 TYR B 36  ? PRO B 38  ? TYR B 15  PRO B 17  
AA5 2 GLY B 73  ? TYR B 75  ? GLY B 52  TYR B 54  
AA6 1 MET B 269 ? VAL B 274 ? MET B 248 VAL B 253 
AA6 2 GLY B 277 ? LEU B 282 ? GLY B 256 LEU B 261 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O MET A 156 ? O MET A 135 N SER A 127 ? N SER A 106 
AA1 2 3 N ALA A 126 ? N ALA A 105 O ILE A 184 ? O ILE A 163 
AA1 3 4 N ALA A 183 ? N ALA A 162 O MET A 239 ? O MET A 218 
AA1 4 5 O VAL A 240 ? O VAL A 219 N TYR A 24  ? N TYR A 3   
AA1 5 6 N THR A 23  ? N THR A 2   O VAL A 254 ? O VAL A 233 
AA1 6 7 N PHE A 260 ? N PHE A 239 O GLN A 387 ? O GLN A 366 
AA1 7 8 O LEU A 392 ? O LEU A 371 N GLY A 376 ? N GLY A 355 
AA1 8 9 O LEU A 377 ? O LEU A 356 N ILE A 316 ? N ILE A 295 
AA2 1 2 N TYR A 37  ? N TYR A 16  O ARG A 74  ? O ARG A 53  
AA3 1 2 N GLY A 270 ? N GLY A 249 O ILE A 281 ? O ILE A 260 
AA4 1 2 O MET B 156 ? O MET B 135 N SER B 127 ? N SER B 106 
AA4 2 3 N ALA B 126 ? N ALA B 105 O ILE B 184 ? O ILE B 163 
AA4 3 4 N ALA B 183 ? N ALA B 162 O MET B 239 ? O MET B 218 
AA4 4 5 O LEU B 238 ? O LEU B 217 N VAL B 26  ? N VAL B 5   
AA4 5 6 N THR B 23  ? N THR B 2   O VAL B 254 ? O VAL B 233 
AA4 6 7 N PHE B 260 ? N PHE B 239 O GLN B 387 ? O GLN B 366 
AA4 7 8 O LEU B 392 ? O LEU B 371 N GLY B 376 ? N GLY B 355 
AA4 8 9 O LEU B 377 ? O LEU B 356 N ILE B 316 ? N ILE B 295 
AA5 1 2 N TYR B 37  ? N TYR B 16  O ARG B 74  ? O ARG B 53  
AA6 1 2 N VAL B 274 ? N VAL B 253 O GLY B 277 ? O GLY B 256 
# 
_pdbx_entry_details.entry_id                   8YST 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 61  ? ? -91.97 30.24   
2 1 SER A 332 ? ? 62.96  -131.75 
3 1 SER B 332 ? ? 61.59  -132.01 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       774 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.89 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -20 ? A MET 1   
2  1 Y 1 A GLY -19 ? A GLY 2   
3  1 Y 1 A SER -18 ? A SER 3   
4  1 Y 1 A SER -17 ? A SER 4   
5  1 Y 1 A HIS -16 ? A HIS 5   
6  1 Y 1 A HIS -15 ? A HIS 6   
7  1 Y 1 A HIS -14 ? A HIS 7   
8  1 Y 1 A HIS -13 ? A HIS 8   
9  1 Y 1 A HIS -12 ? A HIS 9   
10 1 Y 1 A HIS -11 ? A HIS 10  
11 1 Y 1 A SER -10 ? A SER 11  
12 1 Y 1 A SER -9  ? A SER 12  
13 1 Y 1 A GLY -8  ? A GLY 13  
14 1 Y 1 A GLU -7  ? A GLU 14  
15 1 Y 1 A ASN -6  ? A ASN 15  
16 1 Y 1 A LEU -5  ? A LEU 16  
17 1 Y 1 A TYR -4  ? A TYR 17  
18 1 Y 1 A PHE -3  ? A PHE 18  
19 1 Y 1 A GLN -2  ? A GLN 19  
20 1 Y 1 A GLY -1  ? A GLY 20  
21 1 Y 1 A HIS 0   ? A HIS 21  
22 1 Y 1 A ASP 254 ? A ASP 275 
23 1 Y 1 A ASN 255 ? A ASN 276 
24 1 Y 1 B MET -20 ? B MET 1   
25 1 Y 1 B GLY -19 ? B GLY 2   
26 1 Y 1 B SER -18 ? B SER 3   
27 1 Y 1 B SER -17 ? B SER 4   
28 1 Y 1 B HIS -16 ? B HIS 5   
29 1 Y 1 B HIS -15 ? B HIS 6   
30 1 Y 1 B HIS -14 ? B HIS 7   
31 1 Y 1 B HIS -13 ? B HIS 8   
32 1 Y 1 B HIS -12 ? B HIS 9   
33 1 Y 1 B HIS -11 ? B HIS 10  
34 1 Y 1 B SER -10 ? B SER 11  
35 1 Y 1 B SER -9  ? B SER 12  
36 1 Y 1 B GLY -8  ? B GLY 13  
37 1 Y 1 B GLU -7  ? B GLU 14  
38 1 Y 1 B ASN -6  ? B ASN 15  
39 1 Y 1 B LEU -5  ? B LEU 16  
40 1 Y 1 B TYR -4  ? B TYR 17  
41 1 Y 1 B PHE -3  ? B PHE 18  
42 1 Y 1 B GLN -2  ? B GLN 19  
43 1 Y 1 B GLY -1  ? B GLY 20  
44 1 Y 1 B HIS 0   ? B HIS 21  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D7D C10  C N N 1   
A1D7D C15  C N N 2   
A1D7D C01  C N N 3   
A1D7D C02  C N N 4   
A1D7D C03  C N N 5   
A1D7D C04  C N N 6   
A1D7D C05  C N N 7   
A1D7D C06  C N N 8   
A1D7D C07  C N N 9   
A1D7D C08  C N N 10  
A1D7D C09  C N N 11  
A1D7D C11  C N N 12  
A1D7D C12  C N N 13  
A1D7D C16  C N N 14  
A1D7D O13  O N N 15  
A1D7D O14  O N N 16  
A1D7D H1   H N N 17  
A1D7D H2   H N N 18  
A1D7D H3   H N N 19  
A1D7D H4   H N N 20  
A1D7D H5   H N N 21  
A1D7D H6   H N N 22  
A1D7D H7   H N N 23  
A1D7D H8   H N N 24  
A1D7D H9   H N N 25  
A1D7D H10  H N N 26  
A1D7D H11  H N N 27  
A1D7D H12  H N N 28  
A1D7D H13  H N N 29  
A1D7D H14  H N N 30  
A1D7D H15  H N N 31  
A1D7D H16  H N N 32  
A1D7D H17  H N N 33  
A1D7D H18  H N N 34  
A1D7D H19  H N N 35  
A1D7D H20  H N N 36  
A1D7D H21  H N N 37  
A1D7D H22  H N N 38  
A1D7D H23  H N N 39  
A1D7D H24  H N N 40  
A1D7D H25  H N N 41  
A1D7D H26  H N N 42  
ALA   N    N N N 43  
ALA   CA   C N S 44  
ALA   C    C N N 45  
ALA   O    O N N 46  
ALA   CB   C N N 47  
ALA   OXT  O N N 48  
ALA   H    H N N 49  
ALA   H2   H N N 50  
ALA   HA   H N N 51  
ALA   HB1  H N N 52  
ALA   HB2  H N N 53  
ALA   HB3  H N N 54  
ALA   HXT  H N N 55  
ARG   N    N N N 56  
ARG   CA   C N S 57  
ARG   C    C N N 58  
ARG   O    O N N 59  
ARG   CB   C N N 60  
ARG   CG   C N N 61  
ARG   CD   C N N 62  
ARG   NE   N N N 63  
ARG   CZ   C N N 64  
ARG   NH1  N N N 65  
ARG   NH2  N N N 66  
ARG   OXT  O N N 67  
ARG   H    H N N 68  
ARG   H2   H N N 69  
ARG   HA   H N N 70  
ARG   HB2  H N N 71  
ARG   HB3  H N N 72  
ARG   HG2  H N N 73  
ARG   HG3  H N N 74  
ARG   HD2  H N N 75  
ARG   HD3  H N N 76  
ARG   HE   H N N 77  
ARG   HH11 H N N 78  
ARG   HH12 H N N 79  
ARG   HH21 H N N 80  
ARG   HH22 H N N 81  
ARG   HXT  H N N 82  
ASN   N    N N N 83  
ASN   CA   C N S 84  
ASN   C    C N N 85  
ASN   O    O N N 86  
ASN   CB   C N N 87  
ASN   CG   C N N 88  
ASN   OD1  O N N 89  
ASN   ND2  N N N 90  
ASN   OXT  O N N 91  
ASN   H    H N N 92  
ASN   H2   H N N 93  
ASN   HA   H N N 94  
ASN   HB2  H N N 95  
ASN   HB3  H N N 96  
ASN   HD21 H N N 97  
ASN   HD22 H N N 98  
ASN   HXT  H N N 99  
ASP   N    N N N 100 
ASP   CA   C N S 101 
ASP   C    C N N 102 
ASP   O    O N N 103 
ASP   CB   C N N 104 
ASP   CG   C N N 105 
ASP   OD1  O N N 106 
ASP   OD2  O N N 107 
ASP   OXT  O N N 108 
ASP   H    H N N 109 
ASP   H2   H N N 110 
ASP   HA   H N N 111 
ASP   HB2  H N N 112 
ASP   HB3  H N N 113 
ASP   HD2  H N N 114 
ASP   HXT  H N N 115 
CYS   N    N N N 116 
CYS   CA   C N R 117 
CYS   C    C N N 118 
CYS   O    O N N 119 
CYS   CB   C N N 120 
CYS   SG   S N N 121 
CYS   OXT  O N N 122 
CYS   H    H N N 123 
CYS   H2   H N N 124 
CYS   HA   H N N 125 
CYS   HB2  H N N 126 
CYS   HB3  H N N 127 
CYS   HG   H N N 128 
CYS   HXT  H N N 129 
GLN   N    N N N 130 
GLN   CA   C N S 131 
GLN   C    C N N 132 
GLN   O    O N N 133 
GLN   CB   C N N 134 
GLN   CG   C N N 135 
GLN   CD   C N N 136 
GLN   OE1  O N N 137 
GLN   NE2  N N N 138 
GLN   OXT  O N N 139 
GLN   H    H N N 140 
GLN   H2   H N N 141 
GLN   HA   H N N 142 
GLN   HB2  H N N 143 
GLN   HB3  H N N 144 
GLN   HG2  H N N 145 
GLN   HG3  H N N 146 
GLN   HE21 H N N 147 
GLN   HE22 H N N 148 
GLN   HXT  H N N 149 
GLU   N    N N N 150 
GLU   CA   C N S 151 
GLU   C    C N N 152 
GLU   O    O N N 153 
GLU   CB   C N N 154 
GLU   CG   C N N 155 
GLU   CD   C N N 156 
GLU   OE1  O N N 157 
GLU   OE2  O N N 158 
GLU   OXT  O N N 159 
GLU   H    H N N 160 
GLU   H2   H N N 161 
GLU   HA   H N N 162 
GLU   HB2  H N N 163 
GLU   HB3  H N N 164 
GLU   HG2  H N N 165 
GLU   HG3  H N N 166 
GLU   HE2  H N N 167 
GLU   HXT  H N N 168 
GLY   N    N N N 169 
GLY   CA   C N N 170 
GLY   C    C N N 171 
GLY   O    O N N 172 
GLY   OXT  O N N 173 
GLY   H    H N N 174 
GLY   H2   H N N 175 
GLY   HA2  H N N 176 
GLY   HA3  H N N 177 
GLY   HXT  H N N 178 
HIS   N    N N N 179 
HIS   CA   C N S 180 
HIS   C    C N N 181 
HIS   O    O N N 182 
HIS   CB   C N N 183 
HIS   CG   C Y N 184 
HIS   ND1  N Y N 185 
HIS   CD2  C Y N 186 
HIS   CE1  C Y N 187 
HIS   NE2  N Y N 188 
HIS   OXT  O N N 189 
HIS   H    H N N 190 
HIS   H2   H N N 191 
HIS   HA   H N N 192 
HIS   HB2  H N N 193 
HIS   HB3  H N N 194 
HIS   HD1  H N N 195 
HIS   HD2  H N N 196 
HIS   HE1  H N N 197 
HIS   HE2  H N N 198 
HIS   HXT  H N N 199 
HOH   O    O N N 200 
HOH   H1   H N N 201 
HOH   H2   H N N 202 
ILE   N    N N N 203 
ILE   CA   C N S 204 
ILE   C    C N N 205 
ILE   O    O N N 206 
ILE   CB   C N S 207 
ILE   CG1  C N N 208 
ILE   CG2  C N N 209 
ILE   CD1  C N N 210 
ILE   OXT  O N N 211 
ILE   H    H N N 212 
ILE   H2   H N N 213 
ILE   HA   H N N 214 
ILE   HB   H N N 215 
ILE   HG12 H N N 216 
ILE   HG13 H N N 217 
ILE   HG21 H N N 218 
ILE   HG22 H N N 219 
ILE   HG23 H N N 220 
ILE   HD11 H N N 221 
ILE   HD12 H N N 222 
ILE   HD13 H N N 223 
ILE   HXT  H N N 224 
LEU   N    N N N 225 
LEU   CA   C N S 226 
LEU   C    C N N 227 
LEU   O    O N N 228 
LEU   CB   C N N 229 
LEU   CG   C N N 230 
LEU   CD1  C N N 231 
LEU   CD2  C N N 232 
LEU   OXT  O N N 233 
LEU   H    H N N 234 
LEU   H2   H N N 235 
LEU   HA   H N N 236 
LEU   HB2  H N N 237 
LEU   HB3  H N N 238 
LEU   HG   H N N 239 
LEU   HD11 H N N 240 
LEU   HD12 H N N 241 
LEU   HD13 H N N 242 
LEU   HD21 H N N 243 
LEU   HD22 H N N 244 
LEU   HD23 H N N 245 
LEU   HXT  H N N 246 
LYS   N    N N N 247 
LYS   CA   C N S 248 
LYS   C    C N N 249 
LYS   O    O N N 250 
LYS   CB   C N N 251 
LYS   CG   C N N 252 
LYS   CD   C N N 253 
LYS   CE   C N N 254 
LYS   NZ   N N N 255 
LYS   OXT  O N N 256 
LYS   H    H N N 257 
LYS   H2   H N N 258 
LYS   HA   H N N 259 
LYS   HB2  H N N 260 
LYS   HB3  H N N 261 
LYS   HG2  H N N 262 
LYS   HG3  H N N 263 
LYS   HD2  H N N 264 
LYS   HD3  H N N 265 
LYS   HE2  H N N 266 
LYS   HE3  H N N 267 
LYS   HZ1  H N N 268 
LYS   HZ2  H N N 269 
LYS   HZ3  H N N 270 
LYS   HXT  H N N 271 
MET   N    N N N 272 
MET   CA   C N S 273 
MET   C    C N N 274 
MET   O    O N N 275 
MET   CB   C N N 276 
MET   CG   C N N 277 
MET   SD   S N N 278 
MET   CE   C N N 279 
MET   OXT  O N N 280 
MET   H    H N N 281 
MET   H2   H N N 282 
MET   HA   H N N 283 
MET   HB2  H N N 284 
MET   HB3  H N N 285 
MET   HG2  H N N 286 
MET   HG3  H N N 287 
MET   HE1  H N N 288 
MET   HE2  H N N 289 
MET   HE3  H N N 290 
MET   HXT  H N N 291 
PHE   N    N N N 292 
PHE   CA   C N S 293 
PHE   C    C N N 294 
PHE   O    O N N 295 
PHE   CB   C N N 296 
PHE   CG   C Y N 297 
PHE   CD1  C Y N 298 
PHE   CD2  C Y N 299 
PHE   CE1  C Y N 300 
PHE   CE2  C Y N 301 
PHE   CZ   C Y N 302 
PHE   OXT  O N N 303 
PHE   H    H N N 304 
PHE   H2   H N N 305 
PHE   HA   H N N 306 
PHE   HB2  H N N 307 
PHE   HB3  H N N 308 
PHE   HD1  H N N 309 
PHE   HD2  H N N 310 
PHE   HE1  H N N 311 
PHE   HE2  H N N 312 
PHE   HZ   H N N 313 
PHE   HXT  H N N 314 
PRO   N    N N N 315 
PRO   CA   C N S 316 
PRO   C    C N N 317 
PRO   O    O N N 318 
PRO   CB   C N N 319 
PRO   CG   C N N 320 
PRO   CD   C N N 321 
PRO   OXT  O N N 322 
PRO   H    H N N 323 
PRO   HA   H N N 324 
PRO   HB2  H N N 325 
PRO   HB3  H N N 326 
PRO   HG2  H N N 327 
PRO   HG3  H N N 328 
PRO   HD2  H N N 329 
PRO   HD3  H N N 330 
PRO   HXT  H N N 331 
SER   N    N N N 332 
SER   CA   C N S 333 
SER   C    C N N 334 
SER   O    O N N 335 
SER   CB   C N N 336 
SER   OG   O N N 337 
SER   OXT  O N N 338 
SER   H    H N N 339 
SER   H2   H N N 340 
SER   HA   H N N 341 
SER   HB2  H N N 342 
SER   HB3  H N N 343 
SER   HG   H N N 344 
SER   HXT  H N N 345 
THR   N    N N N 346 
THR   CA   C N S 347 
THR   C    C N N 348 
THR   O    O N N 349 
THR   CB   C N R 350 
THR   OG1  O N N 351 
THR   CG2  C N N 352 
THR   OXT  O N N 353 
THR   H    H N N 354 
THR   H2   H N N 355 
THR   HA   H N N 356 
THR   HB   H N N 357 
THR   HG1  H N N 358 
THR   HG21 H N N 359 
THR   HG22 H N N 360 
THR   HG23 H N N 361 
THR   HXT  H N N 362 
TRP   N    N N N 363 
TRP   CA   C N S 364 
TRP   C    C N N 365 
TRP   O    O N N 366 
TRP   CB   C N N 367 
TRP   CG   C Y N 368 
TRP   CD1  C Y N 369 
TRP   CD2  C Y N 370 
TRP   NE1  N Y N 371 
TRP   CE2  C Y N 372 
TRP   CE3  C Y N 373 
TRP   CZ2  C Y N 374 
TRP   CZ3  C Y N 375 
TRP   CH2  C Y N 376 
TRP   OXT  O N N 377 
TRP   H    H N N 378 
TRP   H2   H N N 379 
TRP   HA   H N N 380 
TRP   HB2  H N N 381 
TRP   HB3  H N N 382 
TRP   HD1  H N N 383 
TRP   HE1  H N N 384 
TRP   HE3  H N N 385 
TRP   HZ2  H N N 386 
TRP   HZ3  H N N 387 
TRP   HH2  H N N 388 
TRP   HXT  H N N 389 
TYR   N    N N N 390 
TYR   CA   C N S 391 
TYR   C    C N N 392 
TYR   O    O N N 393 
TYR   CB   C N N 394 
TYR   CG   C Y N 395 
TYR   CD1  C Y N 396 
TYR   CD2  C Y N 397 
TYR   CE1  C Y N 398 
TYR   CE2  C Y N 399 
TYR   CZ   C Y N 400 
TYR   OH   O N N 401 
TYR   OXT  O N N 402 
TYR   H    H N N 403 
TYR   H2   H N N 404 
TYR   HA   H N N 405 
TYR   HB2  H N N 406 
TYR   HB3  H N N 407 
TYR   HD1  H N N 408 
TYR   HD2  H N N 409 
TYR   HE1  H N N 410 
TYR   HE2  H N N 411 
TYR   HH   H N N 412 
TYR   HXT  H N N 413 
VAL   N    N N N 414 
VAL   CA   C N S 415 
VAL   C    C N N 416 
VAL   O    O N N 417 
VAL   CB   C N N 418 
VAL   CG1  C N N 419 
VAL   CG2  C N N 420 
VAL   OXT  O N N 421 
VAL   H    H N N 422 
VAL   H2   H N N 423 
VAL   HA   H N N 424 
VAL   HB   H N N 425 
VAL   HG11 H N N 426 
VAL   HG12 H N N 427 
VAL   HG13 H N N 428 
VAL   HG21 H N N 429 
VAL   HG22 H N N 430 
VAL   HG23 H N N 431 
VAL   HXT  H N N 432 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D7D C01 C02  sing N N 1   
A1D7D C01 O13  doub N N 2   
A1D7D C02 C03  sing N N 3   
A1D7D C03 C04  sing N N 4   
A1D7D C03 O14  doub N N 5   
A1D7D C04 C05  sing N N 6   
A1D7D C05 C06  sing N N 7   
A1D7D C06 C07  sing N N 8   
A1D7D C07 C08  sing N N 9   
A1D7D C08 C09  sing N N 10  
A1D7D C09 C10  sing N N 11  
A1D7D C10 C11  sing N N 12  
A1D7D C11 C12  sing N N 13  
A1D7D C12 C15  sing N N 14  
A1D7D C15 C16  sing N N 15  
A1D7D C10 H1   sing N N 16  
A1D7D C10 H2   sing N N 17  
A1D7D C15 H3   sing N N 18  
A1D7D C15 H4   sing N N 19  
A1D7D C01 H5   sing N N 20  
A1D7D C02 H6   sing N N 21  
A1D7D C02 H7   sing N N 22  
A1D7D C04 H8   sing N N 23  
A1D7D C04 H9   sing N N 24  
A1D7D C05 H10  sing N N 25  
A1D7D C05 H11  sing N N 26  
A1D7D C06 H12  sing N N 27  
A1D7D C06 H13  sing N N 28  
A1D7D C07 H14  sing N N 29  
A1D7D C07 H15  sing N N 30  
A1D7D C08 H16  sing N N 31  
A1D7D C08 H17  sing N N 32  
A1D7D C09 H18  sing N N 33  
A1D7D C09 H19  sing N N 34  
A1D7D C11 H20  sing N N 35  
A1D7D C11 H21  sing N N 36  
A1D7D C12 H22  sing N N 37  
A1D7D C12 H23  sing N N 38  
A1D7D C16 H24  sing N N 39  
A1D7D C16 H25  sing N N 40  
A1D7D C16 H26  sing N N 41  
ALA   N   CA   sing N N 42  
ALA   N   H    sing N N 43  
ALA   N   H2   sing N N 44  
ALA   CA  C    sing N N 45  
ALA   CA  CB   sing N N 46  
ALA   CA  HA   sing N N 47  
ALA   C   O    doub N N 48  
ALA   C   OXT  sing N N 49  
ALA   CB  HB1  sing N N 50  
ALA   CB  HB2  sing N N 51  
ALA   CB  HB3  sing N N 52  
ALA   OXT HXT  sing N N 53  
ARG   N   CA   sing N N 54  
ARG   N   H    sing N N 55  
ARG   N   H2   sing N N 56  
ARG   CA  C    sing N N 57  
ARG   CA  CB   sing N N 58  
ARG   CA  HA   sing N N 59  
ARG   C   O    doub N N 60  
ARG   C   OXT  sing N N 61  
ARG   CB  CG   sing N N 62  
ARG   CB  HB2  sing N N 63  
ARG   CB  HB3  sing N N 64  
ARG   CG  CD   sing N N 65  
ARG   CG  HG2  sing N N 66  
ARG   CG  HG3  sing N N 67  
ARG   CD  NE   sing N N 68  
ARG   CD  HD2  sing N N 69  
ARG   CD  HD3  sing N N 70  
ARG   NE  CZ   sing N N 71  
ARG   NE  HE   sing N N 72  
ARG   CZ  NH1  sing N N 73  
ARG   CZ  NH2  doub N N 74  
ARG   NH1 HH11 sing N N 75  
ARG   NH1 HH12 sing N N 76  
ARG   NH2 HH21 sing N N 77  
ARG   NH2 HH22 sing N N 78  
ARG   OXT HXT  sing N N 79  
ASN   N   CA   sing N N 80  
ASN   N   H    sing N N 81  
ASN   N   H2   sing N N 82  
ASN   CA  C    sing N N 83  
ASN   CA  CB   sing N N 84  
ASN   CA  HA   sing N N 85  
ASN   C   O    doub N N 86  
ASN   C   OXT  sing N N 87  
ASN   CB  CG   sing N N 88  
ASN   CB  HB2  sing N N 89  
ASN   CB  HB3  sing N N 90  
ASN   CG  OD1  doub N N 91  
ASN   CG  ND2  sing N N 92  
ASN   ND2 HD21 sing N N 93  
ASN   ND2 HD22 sing N N 94  
ASN   OXT HXT  sing N N 95  
ASP   N   CA   sing N N 96  
ASP   N   H    sing N N 97  
ASP   N   H2   sing N N 98  
ASP   CA  C    sing N N 99  
ASP   CA  CB   sing N N 100 
ASP   CA  HA   sing N N 101 
ASP   C   O    doub N N 102 
ASP   C   OXT  sing N N 103 
ASP   CB  CG   sing N N 104 
ASP   CB  HB2  sing N N 105 
ASP   CB  HB3  sing N N 106 
ASP   CG  OD1  doub N N 107 
ASP   CG  OD2  sing N N 108 
ASP   OD2 HD2  sing N N 109 
ASP   OXT HXT  sing N N 110 
CYS   N   CA   sing N N 111 
CYS   N   H    sing N N 112 
CYS   N   H2   sing N N 113 
CYS   CA  C    sing N N 114 
CYS   CA  CB   sing N N 115 
CYS   CA  HA   sing N N 116 
CYS   C   O    doub N N 117 
CYS   C   OXT  sing N N 118 
CYS   CB  SG   sing N N 119 
CYS   CB  HB2  sing N N 120 
CYS   CB  HB3  sing N N 121 
CYS   SG  HG   sing N N 122 
CYS   OXT HXT  sing N N 123 
GLN   N   CA   sing N N 124 
GLN   N   H    sing N N 125 
GLN   N   H2   sing N N 126 
GLN   CA  C    sing N N 127 
GLN   CA  CB   sing N N 128 
GLN   CA  HA   sing N N 129 
GLN   C   O    doub N N 130 
GLN   C   OXT  sing N N 131 
GLN   CB  CG   sing N N 132 
GLN   CB  HB2  sing N N 133 
GLN   CB  HB3  sing N N 134 
GLN   CG  CD   sing N N 135 
GLN   CG  HG2  sing N N 136 
GLN   CG  HG3  sing N N 137 
GLN   CD  OE1  doub N N 138 
GLN   CD  NE2  sing N N 139 
GLN   NE2 HE21 sing N N 140 
GLN   NE2 HE22 sing N N 141 
GLN   OXT HXT  sing N N 142 
GLU   N   CA   sing N N 143 
GLU   N   H    sing N N 144 
GLU   N   H2   sing N N 145 
GLU   CA  C    sing N N 146 
GLU   CA  CB   sing N N 147 
GLU   CA  HA   sing N N 148 
GLU   C   O    doub N N 149 
GLU   C   OXT  sing N N 150 
GLU   CB  CG   sing N N 151 
GLU   CB  HB2  sing N N 152 
GLU   CB  HB3  sing N N 153 
GLU   CG  CD   sing N N 154 
GLU   CG  HG2  sing N N 155 
GLU   CG  HG3  sing N N 156 
GLU   CD  OE1  doub N N 157 
GLU   CD  OE2  sing N N 158 
GLU   OE2 HE2  sing N N 159 
GLU   OXT HXT  sing N N 160 
GLY   N   CA   sing N N 161 
GLY   N   H    sing N N 162 
GLY   N   H2   sing N N 163 
GLY   CA  C    sing N N 164 
GLY   CA  HA2  sing N N 165 
GLY   CA  HA3  sing N N 166 
GLY   C   O    doub N N 167 
GLY   C   OXT  sing N N 168 
GLY   OXT HXT  sing N N 169 
HIS   N   CA   sing N N 170 
HIS   N   H    sing N N 171 
HIS   N   H2   sing N N 172 
HIS   CA  C    sing N N 173 
HIS   CA  CB   sing N N 174 
HIS   CA  HA   sing N N 175 
HIS   C   O    doub N N 176 
HIS   C   OXT  sing N N 177 
HIS   CB  CG   sing N N 178 
HIS   CB  HB2  sing N N 179 
HIS   CB  HB3  sing N N 180 
HIS   CG  ND1  sing Y N 181 
HIS   CG  CD2  doub Y N 182 
HIS   ND1 CE1  doub Y N 183 
HIS   ND1 HD1  sing N N 184 
HIS   CD2 NE2  sing Y N 185 
HIS   CD2 HD2  sing N N 186 
HIS   CE1 NE2  sing Y N 187 
HIS   CE1 HE1  sing N N 188 
HIS   NE2 HE2  sing N N 189 
HIS   OXT HXT  sing N N 190 
HOH   O   H1   sing N N 191 
HOH   O   H2   sing N N 192 
ILE   N   CA   sing N N 193 
ILE   N   H    sing N N 194 
ILE   N   H2   sing N N 195 
ILE   CA  C    sing N N 196 
ILE   CA  CB   sing N N 197 
ILE   CA  HA   sing N N 198 
ILE   C   O    doub N N 199 
ILE   C   OXT  sing N N 200 
ILE   CB  CG1  sing N N 201 
ILE   CB  CG2  sing N N 202 
ILE   CB  HB   sing N N 203 
ILE   CG1 CD1  sing N N 204 
ILE   CG1 HG12 sing N N 205 
ILE   CG1 HG13 sing N N 206 
ILE   CG2 HG21 sing N N 207 
ILE   CG2 HG22 sing N N 208 
ILE   CG2 HG23 sing N N 209 
ILE   CD1 HD11 sing N N 210 
ILE   CD1 HD12 sing N N 211 
ILE   CD1 HD13 sing N N 212 
ILE   OXT HXT  sing N N 213 
LEU   N   CA   sing N N 214 
LEU   N   H    sing N N 215 
LEU   N   H2   sing N N 216 
LEU   CA  C    sing N N 217 
LEU   CA  CB   sing N N 218 
LEU   CA  HA   sing N N 219 
LEU   C   O    doub N N 220 
LEU   C   OXT  sing N N 221 
LEU   CB  CG   sing N N 222 
LEU   CB  HB2  sing N N 223 
LEU   CB  HB3  sing N N 224 
LEU   CG  CD1  sing N N 225 
LEU   CG  CD2  sing N N 226 
LEU   CG  HG   sing N N 227 
LEU   CD1 HD11 sing N N 228 
LEU   CD1 HD12 sing N N 229 
LEU   CD1 HD13 sing N N 230 
LEU   CD2 HD21 sing N N 231 
LEU   CD2 HD22 sing N N 232 
LEU   CD2 HD23 sing N N 233 
LEU   OXT HXT  sing N N 234 
LYS   N   CA   sing N N 235 
LYS   N   H    sing N N 236 
LYS   N   H2   sing N N 237 
LYS   CA  C    sing N N 238 
LYS   CA  CB   sing N N 239 
LYS   CA  HA   sing N N 240 
LYS   C   O    doub N N 241 
LYS   C   OXT  sing N N 242 
LYS   CB  CG   sing N N 243 
LYS   CB  HB2  sing N N 244 
LYS   CB  HB3  sing N N 245 
LYS   CG  CD   sing N N 246 
LYS   CG  HG2  sing N N 247 
LYS   CG  HG3  sing N N 248 
LYS   CD  CE   sing N N 249 
LYS   CD  HD2  sing N N 250 
LYS   CD  HD3  sing N N 251 
LYS   CE  NZ   sing N N 252 
LYS   CE  HE2  sing N N 253 
LYS   CE  HE3  sing N N 254 
LYS   NZ  HZ1  sing N N 255 
LYS   NZ  HZ2  sing N N 256 
LYS   NZ  HZ3  sing N N 257 
LYS   OXT HXT  sing N N 258 
MET   N   CA   sing N N 259 
MET   N   H    sing N N 260 
MET   N   H2   sing N N 261 
MET   CA  C    sing N N 262 
MET   CA  CB   sing N N 263 
MET   CA  HA   sing N N 264 
MET   C   O    doub N N 265 
MET   C   OXT  sing N N 266 
MET   CB  CG   sing N N 267 
MET   CB  HB2  sing N N 268 
MET   CB  HB3  sing N N 269 
MET   CG  SD   sing N N 270 
MET   CG  HG2  sing N N 271 
MET   CG  HG3  sing N N 272 
MET   SD  CE   sing N N 273 
MET   CE  HE1  sing N N 274 
MET   CE  HE2  sing N N 275 
MET   CE  HE3  sing N N 276 
MET   OXT HXT  sing N N 277 
PHE   N   CA   sing N N 278 
PHE   N   H    sing N N 279 
PHE   N   H2   sing N N 280 
PHE   CA  C    sing N N 281 
PHE   CA  CB   sing N N 282 
PHE   CA  HA   sing N N 283 
PHE   C   O    doub N N 284 
PHE   C   OXT  sing N N 285 
PHE   CB  CG   sing N N 286 
PHE   CB  HB2  sing N N 287 
PHE   CB  HB3  sing N N 288 
PHE   CG  CD1  doub Y N 289 
PHE   CG  CD2  sing Y N 290 
PHE   CD1 CE1  sing Y N 291 
PHE   CD1 HD1  sing N N 292 
PHE   CD2 CE2  doub Y N 293 
PHE   CD2 HD2  sing N N 294 
PHE   CE1 CZ   doub Y N 295 
PHE   CE1 HE1  sing N N 296 
PHE   CE2 CZ   sing Y N 297 
PHE   CE2 HE2  sing N N 298 
PHE   CZ  HZ   sing N N 299 
PHE   OXT HXT  sing N N 300 
PRO   N   CA   sing N N 301 
PRO   N   CD   sing N N 302 
PRO   N   H    sing N N 303 
PRO   CA  C    sing N N 304 
PRO   CA  CB   sing N N 305 
PRO   CA  HA   sing N N 306 
PRO   C   O    doub N N 307 
PRO   C   OXT  sing N N 308 
PRO   CB  CG   sing N N 309 
PRO   CB  HB2  sing N N 310 
PRO   CB  HB3  sing N N 311 
PRO   CG  CD   sing N N 312 
PRO   CG  HG2  sing N N 313 
PRO   CG  HG3  sing N N 314 
PRO   CD  HD2  sing N N 315 
PRO   CD  HD3  sing N N 316 
PRO   OXT HXT  sing N N 317 
SER   N   CA   sing N N 318 
SER   N   H    sing N N 319 
SER   N   H2   sing N N 320 
SER   CA  C    sing N N 321 
SER   CA  CB   sing N N 322 
SER   CA  HA   sing N N 323 
SER   C   O    doub N N 324 
SER   C   OXT  sing N N 325 
SER   CB  OG   sing N N 326 
SER   CB  HB2  sing N N 327 
SER   CB  HB3  sing N N 328 
SER   OG  HG   sing N N 329 
SER   OXT HXT  sing N N 330 
THR   N   CA   sing N N 331 
THR   N   H    sing N N 332 
THR   N   H2   sing N N 333 
THR   CA  C    sing N N 334 
THR   CA  CB   sing N N 335 
THR   CA  HA   sing N N 336 
THR   C   O    doub N N 337 
THR   C   OXT  sing N N 338 
THR   CB  OG1  sing N N 339 
THR   CB  CG2  sing N N 340 
THR   CB  HB   sing N N 341 
THR   OG1 HG1  sing N N 342 
THR   CG2 HG21 sing N N 343 
THR   CG2 HG22 sing N N 344 
THR   CG2 HG23 sing N N 345 
THR   OXT HXT  sing N N 346 
TRP   N   CA   sing N N 347 
TRP   N   H    sing N N 348 
TRP   N   H2   sing N N 349 
TRP   CA  C    sing N N 350 
TRP   CA  CB   sing N N 351 
TRP   CA  HA   sing N N 352 
TRP   C   O    doub N N 353 
TRP   C   OXT  sing N N 354 
TRP   CB  CG   sing N N 355 
TRP   CB  HB2  sing N N 356 
TRP   CB  HB3  sing N N 357 
TRP   CG  CD1  doub Y N 358 
TRP   CG  CD2  sing Y N 359 
TRP   CD1 NE1  sing Y N 360 
TRP   CD1 HD1  sing N N 361 
TRP   CD2 CE2  doub Y N 362 
TRP   CD2 CE3  sing Y N 363 
TRP   NE1 CE2  sing Y N 364 
TRP   NE1 HE1  sing N N 365 
TRP   CE2 CZ2  sing Y N 366 
TRP   CE3 CZ3  doub Y N 367 
TRP   CE3 HE3  sing N N 368 
TRP   CZ2 CH2  doub Y N 369 
TRP   CZ2 HZ2  sing N N 370 
TRP   CZ3 CH2  sing Y N 371 
TRP   CZ3 HZ3  sing N N 372 
TRP   CH2 HH2  sing N N 373 
TRP   OXT HXT  sing N N 374 
TYR   N   CA   sing N N 375 
TYR   N   H    sing N N 376 
TYR   N   H2   sing N N 377 
TYR   CA  C    sing N N 378 
TYR   CA  CB   sing N N 379 
TYR   CA  HA   sing N N 380 
TYR   C   O    doub N N 381 
TYR   C   OXT  sing N N 382 
TYR   CB  CG   sing N N 383 
TYR   CB  HB2  sing N N 384 
TYR   CB  HB3  sing N N 385 
TYR   CG  CD1  doub Y N 386 
TYR   CG  CD2  sing Y N 387 
TYR   CD1 CE1  sing Y N 388 
TYR   CD1 HD1  sing N N 389 
TYR   CD2 CE2  doub Y N 390 
TYR   CD2 HD2  sing N N 391 
TYR   CE1 CZ   doub Y N 392 
TYR   CE1 HE1  sing N N 393 
TYR   CE2 CZ   sing Y N 394 
TYR   CE2 HE2  sing N N 395 
TYR   CZ  OH   sing N N 396 
TYR   OH  HH   sing N N 397 
TYR   OXT HXT  sing N N 398 
VAL   N   CA   sing N N 399 
VAL   N   H    sing N N 400 
VAL   N   H2   sing N N 401 
VAL   CA  C    sing N N 402 
VAL   CA  CB   sing N N 403 
VAL   CA  HA   sing N N 404 
VAL   C   O    doub N N 405 
VAL   C   OXT  sing N N 406 
VAL   CB  CG1  sing N N 407 
VAL   CB  CG2  sing N N 408 
VAL   CB  HB   sing N N 409 
VAL   CG1 HG11 sing N N 410 
VAL   CG1 HG12 sing N N 411 
VAL   CG1 HG13 sing N N 412 
VAL   CG2 HG21 sing N N 413 
VAL   CG2 HG22 sing N N 414 
VAL   CG2 HG23 sing N N 415 
VAL   OXT HXT  sing N N 416 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Shenzhen science and technology program'                         China 20170330155106581 1 
'Key-Area Research and Development Program of Guangdong Province' China 2020B0303070002   2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8YSP 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YST 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020471 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008815 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007452 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . MET   A 1 22  ? -6.37163  13.09695  -7.65575  1.000 35.48505 ? 1   MET   A N   1 
ATOM   2    C CA  . MET   A 1 22  ? -6.50395  12.68883  -6.26270  1.000 40.49744 ? 1   MET   A CA  1 
ATOM   3    C C   . MET   A 1 22  ? -5.39974  11.70309  -5.88703  1.000 34.23198 ? 1   MET   A C   1 
ATOM   4    O O   . MET   A 1 22  ? -4.22714  11.93406  -6.18147  1.000 38.46947 ? 1   MET   A O   1 
ATOM   5    C CB  . MET   A 1 22  ? -7.88384  12.07269  -6.01397  1.000 42.17465 ? 1   MET   A CB  1 
ATOM   6    C CG  . MET   A 1 22  ? -9.00169  13.10009  -5.86914  1.000 50.36772 ? 1   MET   A CG  1 
ATOM   7    S SD  . MET   A 1 22  ? -9.04066  13.90601  -4.25365  1.000 68.52746 ? 1   MET   A SD  1 
ATOM   8    C CE  . MET   A 1 22  ? -9.02299  12.48313  -3.16681  1.000 40.11511 ? 1   MET   A CE  1 
ATOM   9    N N   . THR   A 1 23  ? -5.77855  10.60532  -5.23916  1.000 22.49895 ? 2   THR   A N   1 
ATOM   10   C CA  . THR   A 1 23  ? -4.83937  9.57423   -4.82175  1.000 20.89281 ? 2   THR   A CA  1 
ATOM   11   C C   . THR   A 1 23  ? -4.88202  8.40475   -5.79766  1.000 17.94346 ? 2   THR   A C   1 
ATOM   12   O O   . THR   A 1 23  ? -5.95931  7.96411   -6.20826  1.000 22.43489 ? 2   THR   A O   1 
ATOM   13   C CB  . THR   A 1 23  ? -5.15712  9.09813   -3.40195  1.000 19.75092 ? 2   THR   A CB  1 
ATOM   14   O OG1 . THR   A 1 23  ? -4.92304  10.17132  -2.48221  1.000 28.00763 ? 2   THR   A OG1 1 
ATOM   15   C CG2 . THR   A 1 23  ? -4.28723  7.91177   -3.01452  1.000 20.60258 ? 2   THR   A CG2 1 
ATOM   16   N N   . TYR   A 1 24  ? -3.70388  7.90592   -6.16320  1.000 13.80954 ? 3   TYR   A N   1 
ATOM   17   C CA  . TYR   A 1 24  ? -3.55375  6.87275   -7.17844  1.000 19.37955 ? 3   TYR   A CA  1 
ATOM   18   C C   . TYR   A 1 24  ? -3.10401  5.55755   -6.55885  1.000 19.66990 ? 3   TYR   A C   1 
ATOM   19   O O   . TYR   A 1 24  ? -2.22148  5.53312   -5.69404  1.000 13.41995 ? 3   TYR   A O   1 
ATOM   20   C CB  . TYR   A 1 24  ? -2.54191  7.30418   -8.24295  1.000 16.76697 ? 3   TYR   A CB  1 
ATOM   21   C CG  . TYR   A 1 24  ? -3.04907  8.37820   -9.16946  1.000 19.24093 ? 3   TYR   A CG  1 
ATOM   22   C CD1 . TYR   A 1 24  ? -3.00007  9.71517   -8.80555  1.000 26.13723 ? 3   TYR   A CD1 1 
ATOM   23   C CD2 . TYR   A 1 24  ? -3.54261  8.05732   -10.42504 1.000 32.15544 ? 3   TYR   A CD2 1 
ATOM   24   C CE1 . TYR   A 1 24  ? -3.45592  10.70327  -9.65614  1.000 29.86616 ? 3   TYR   A CE1 1 
ATOM   25   C CE2 . TYR   A 1 24  ? -3.99310  9.03567   -11.28374 1.000 31.92603 ? 3   TYR   A CE2 1 
ATOM   26   C CZ  . TYR   A 1 24  ? -3.95113  10.35824  -10.89373 1.000 24.60149 ? 3   TYR   A CZ  1 
ATOM   27   O OH  . TYR   A 1 24  ? -4.40502  11.33955  -11.74537 1.000 27.04899 ? 3   TYR   A OH  1 
ATOM   28   N N   . ILE   A 1 25  ? -3.71656  4.46660   -7.00729  1.000 12.43257 ? 4   ILE   A N   1 
ATOM   29   C CA  . ILE   A 1 25  ? -3.24262  3.12389   -6.69337  1.000 12.49136 ? 4   ILE   A CA  1 
ATOM   30   C C   . ILE   A 1 25  ? -2.27550  2.71859   -7.80061  1.000 14.63961 ? 4   ILE   A C   1 
ATOM   31   O O   . ILE   A 1 25  ? -2.66799  2.57817   -8.96206  1.000 16.65147 ? 4   ILE   A O   1 
ATOM   32   C CB  . ILE   A 1 25  ? -4.40202  2.12993   -6.55696  1.000 12.59714 ? 4   ILE   A CB  1 
ATOM   33   C CG1 . ILE   A 1 25  ? -5.29368  2.52248   -5.37197  1.000 14.36849 ? 4   ILE   A CG1 1 
ATOM   34   C CG2 . ILE   A 1 25  ? -3.87664  0.70890   -6.41460  1.000 11.85866 ? 4   ILE   A CG2 1 
ATOM   35   C CD1 . ILE   A 1 25  ? -6.24944  1.43401   -4.92036  1.000 21.04707 ? 4   ILE   A CD1 1 
ATOM   36   N N   . VAL   A 1 26  ? -1.00637  2.54104   -7.44289  1.000 10.25946 ? 5   VAL   A N   1 
ATOM   37   C CA  . VAL   A 1 26  ? 0.04587   2.30397   -8.43088  1.000 15.18018 ? 5   VAL   A CA  1 
ATOM   38   C C   . VAL   A 1 26  ? 0.22837   0.81920   -8.71293  1.000 15.28502 ? 5   VAL   A C   1 
ATOM   39   O O   . VAL   A 1 26  ? 0.30875   0.40182   -9.87179  1.000 13.31371 ? 5   VAL   A O   1 
ATOM   40   C CB  . VAL   A 1 26  ? 1.36824   2.94704   -7.95979  1.000 15.29573 ? 5   VAL   A CB  1 
ATOM   41   C CG1 . VAL   A 1 26  ? 2.47389   2.68316   -8.96997  1.000 18.51638 ? 5   VAL   A CG1 1 
ATOM   42   C CG2 . VAL   A 1 26  ? 1.18623   4.43607   -7.75151  1.000 16.75108 ? 5   VAL   A CG2 1 
ATOM   43   N N   . SER   A 1 27  ? 0.30900   0.00008   -7.66821  1.000 8.78923  ? 6   SER   A N   1 
ATOM   44   C CA  . SER   A 1 27  ? 0.60332   -1.41596  -7.83891  1.000 10.79796 ? 6   SER   A CA  1 
ATOM   45   C C   . SER   A 1 27  ? 0.14179   -2.18346  -6.61022  1.000 14.32629 ? 6   SER   A C   1 
ATOM   46   O O   . SER   A 1 27  ? -0.20105  -1.60302  -5.57735  1.000 9.88922  ? 6   SER   A O   1 
ATOM   47   C CB  . SER   A 1 27  ? 2.09504   -1.64997  -8.08587  1.000 10.94720 ? 6   SER   A CB  1 
ATOM   48   O OG  . SER   A 1 27  ? 2.34623   -2.99352  -8.45908  1.000 13.29478 ? 6   SER   A OG  1 
ATOM   49   N N   . THR   A 1 28  ? 0.14838   -3.50938  -6.74397  1.000 11.18728 ? 7   THR   A N   1 
ATOM   50   C CA  . THR   A 1 28  ? -0.26859  -4.42670  -5.69523  1.000 8.96332  ? 7   THR   A CA  1 
ATOM   51   C C   . THR   A 1 28  ? 0.65992   -5.63330  -5.69003  1.000 8.63083  ? 7   THR   A C   1 
ATOM   52   O O   . THR   A 1 28  ? 1.36537   -5.90304  -6.66412  1.000 14.45222 ? 7   THR   A O   1 
ATOM   53   C CB  . THR   A 1 28  ? -1.71901  -4.89603  -5.88852  1.000 9.97719  ? 7   THR   A CB  1 
ATOM   54   O OG1 . THR   A 1 28  ? -1.88204  -5.39491  -7.22129  1.000 11.01843 ? 7   THR   A OG1 1 
ATOM   55   C CG2 . THR   A 1 28  ? -2.70510  -3.75457  -5.64706  1.000 10.58506 ? 7   THR   A CG2 1 
ATOM   56   N N   . SER   A 1 29  ? 0.64546   -6.36339  -4.57699  1.000 6.79438  ? 8   SER   A N   1 
ATOM   57   C CA  . SER   A 1 29  ? 1.38817   -7.61081  -4.45840  1.000 9.07806  ? 8   SER   A CA  1 
ATOM   58   C C   . SER   A 1 29  ? 0.71006   -8.47541  -3.40581  1.000 12.59375 ? 8   SER   A C   1 
ATOM   59   O O   . SER   A 1 29  ? -0.12911  -8.00096  -2.63567  1.000 11.23261 ? 8   SER   A O   1 
ATOM   60   C CB  . SER   A 1 29  ? 2.85967   -7.36490  -4.10323  1.000 10.76995 ? 8   SER   A CB  1 
ATOM   61   O OG  . SER   A 1 29  ? 2.99740   -6.90188  -2.77054  1.000 12.89289 ? 8   SER   A OG  1 
ATOM   62   N N   . THR   A 1 30  ? 1.06500   -9.76031  -3.39940  1.000 8.83261  ? 9   THR   A N   1 
ATOM   63   C CA  . THR   A 1 30  ? 0.54440   -10.70127 -2.41690  1.000 7.51338  ? 9   THR   A CA  1 
ATOM   64   C C   . THR   A 1 30  ? 1.67855   -11.58534 -1.92009  1.000 12.55177 ? 9   THR   A C   1 
ATOM   65   O O   . THR   A 1 30  ? 2.74800   -11.65962 -2.52917  1.000 9.96673  ? 9   THR   A O   1 
ATOM   66   C CB  . THR   A 1 30  ? -0.57079  -11.59260 -2.98362  1.000 16.01061 ? 9   THR   A CB  1 
ATOM   67   O OG1 . THR   A 1 30  ? -0.03578  -12.42841 -4.01825  1.000 11.99673 ? 9   THR   A OG1 1 
ATOM   68   C CG2 . THR   A 1 30  ? -1.71689  -10.75244 -3.54063  1.000 9.78944  ? 9   THR   A CG2 1 
ATOM   69   N N   . ALA   A 1 31  ? 1.42763   -12.26643 -0.80406  1.000 11.97875 ? 10  ALA   A N   1 
ATOM   70   C CA  . ALA   A 1 31  ? 2.38013   -13.22917 -0.26715  1.000 12.98724 ? 10  ALA   A CA  1 
ATOM   71   C C   . ALA   A 1 31  ? 1.62132   -14.29459 0.50854   1.000 12.62463 ? 10  ALA   A C   1 
ATOM   72   O O   . ALA   A 1 31  ? 0.72967   -13.97079 1.29846   1.000 11.34920 ? 10  ALA   A O   1 
ATOM   73   C CB  . ALA   A 1 31  ? 3.41597   -12.54616 0.63273   1.000 13.76182 ? 10  ALA   A CB  1 
ATOM   74   N N   . PHE   A 1 32  ? 1.97893   -15.55601 0.28667   1.000 11.28063 ? 11  PHE   A N   1 
ATOM   75   C CA  . PHE   A 1 32  ? 1.32017   -16.67726 0.93565   1.000 9.41158  ? 11  PHE   A CA  1 
ATOM   76   C C   . PHE   A 1 32  ? 2.35011   -17.63078 1.51753   1.000 9.70831  ? 11  PHE   A C   1 
ATOM   77   O O   . PHE   A 1 32  ? 3.49953   -17.66384 1.06443   1.000 13.53042 ? 11  PHE   A O   1 
ATOM   78   C CB  . PHE   A 1 32  ? 0.41568   -17.43021 -0.05165  1.000 9.93672  ? 11  PHE   A CB  1 
ATOM   79   C CG  . PHE   A 1 32  ? -0.78303  -16.64459 -0.48186  1.000 10.06463 ? 11  PHE   A CG  1 
ATOM   80   C CD1 . PHE   A 1 32  ? -1.93226  -16.63274 0.29344   1.000 8.80278  ? 11  PHE   A CD1 1 
ATOM   81   C CD2 . PHE   A 1 32  ? -0.75916  -15.90546 -1.65184  1.000 9.65970  ? 11  PHE   A CD2 1 
ATOM   82   C CE1 . PHE   A 1 32  ? -3.03821  -15.90637 -0.09484  1.000 9.65205  ? 11  PHE   A CE1 1 
ATOM   83   C CE2 . PHE   A 1 32  ? -1.86326  -15.17464 -2.04686  1.000 8.63731  ? 11  PHE   A CE2 1 
ATOM   84   C CZ  . PHE   A 1 32  ? -3.00368  -15.17509 -1.26558  1.000 9.67609  ? 11  PHE   A CZ  1 
ATOM   85   N N   . PRO   A 1 33  ? 1.97483   -18.40627 2.54055   1.000 14.21005 ? 12  PRO   A N   1 
ATOM   86   C CA  . PRO   A 1 33  ? 2.91627   -19.38633 3.09912   1.000 17.46707 ? 12  PRO   A CA  1 
ATOM   87   C C   . PRO   A 1 33  ? 3.15882   -20.54946 2.15101   1.000 16.35493 ? 12  PRO   A C   1 
ATOM   88   O O   . PRO   A 1 33  ? 2.53682   -20.63072 1.08733   1.000 16.28911 ? 12  PRO   A O   1 
ATOM   89   C CB  . PRO   A 1 33  ? 2.23047   -19.84123 4.39261   1.000 18.64269 ? 12  PRO   A CB  1 
ATOM   90   C CG  . PRO   A 1 33  ? 0.78333   -19.55096 4.18097   1.000 15.34369 ? 12  PRO   A CG  1 
ATOM   91   C CD  . PRO   A 1 33  ? 0.72253   -18.33150 3.31421   1.000 11.32281 ? 12  PRO   A CD  1 
ATOM   92   N N   . GLU   A 1 34  ? 4.06308   -21.45642 2.52324   1.000 16.32903 ? 13  GLU   A N   1 
ATOM   93   C CA  . GLU   A 1 34  ? 4.47059   -22.51505 1.60712   1.000 15.65941 ? 13  GLU   A CA  1 
ATOM   94   C C   . GLU   A 1 34  ? 3.42728   -23.61689 1.45848   1.000 18.09095 ? 13  GLU   A C   1 
ATOM   95   O O   . GLU   A 1 34  ? 3.40181   -24.28744 0.42000   1.000 20.90279 ? 13  GLU   A O   1 
ATOM   96   C CB  . GLU   A 1 34  ? 5.80295   -23.12402 2.06067   1.000 23.62514 ? 13  GLU   A CB  1 
ATOM   97   C CG  . GLU   A 1 34  ? 5.70392   -24.01307 3.29409   1.000 29.79397 ? 13  GLU   A CG  1 
ATOM   98   C CD  . GLU   A 1 34  ? 7.04750   -24.56985 3.73716   1.000 36.92114 ? 13  GLU   A CD  1 
ATOM   99   O OE1 . GLU   A 1 34  ? 7.99104   -24.58285 2.91762   1.000 23.18620 ? 13  GLU   A OE1 1 
ATOM   100  O OE2 . GLU   A 1 34  ? 7.15750   -24.99923 4.90511   1.000 34.96961 ? 13  GLU   A OE2 1 
ATOM   101  N N   . ASN   A 1 35  ? 2.55988   -23.81330 2.45012   1.000 14.09859 ? 14  ASN   A N   1 
ATOM   102  C CA  . ASN   A 1 35  ? 1.68770   -24.98364 2.50448   1.000 14.09556 ? 14  ASN   A CA  1 
ATOM   103  C C   . ASN   A 1 35  ? 0.27628   -24.61205 2.05910   1.000 18.60573 ? 14  ASN   A C   1 
ATOM   104  O O   . ASN   A 1 35  ? -0.42548  -23.86192 2.74557   1.000 15.47662 ? 14  ASN   A O   1 
ATOM   105  C CB  . ASN   A 1 35  ? 1.67772   -25.57623 3.91123   1.000 15.36665 ? 14  ASN   A CB  1 
ATOM   106  C CG  . ASN   A 1 35  ? 2.97640   -26.27665 4.25451   1.000 21.38128 ? 14  ASN   A CG  1 
ATOM   107  O OD1 . ASN   A 1 35  ? 3.62353   -26.86586 3.39064   1.000 27.81416 ? 14  ASN   A OD1 1 
ATOM   108  N ND2 . ASN   A 1 35  ? 3.36932   -26.20806 5.52083   1.000 25.80253 ? 14  ASN   A ND2 1 
ATOM   109  N N   . TYR   A 1 36  ? -0.13783  -25.15683 0.91932   1.000 14.16470 ? 15  TYR   A N   1 
ATOM   110  C CA  . TYR   A 1 36  ? -1.50327  -25.04537 0.42455   1.000 13.86315 ? 15  TYR   A CA  1 
ATOM   111  C C   . TYR   A 1 36  ? -2.22169  -26.36513 0.67835   1.000 16.93331 ? 15  TYR   A C   1 
ATOM   112  O O   . TYR   A 1 36  ? -1.78849  -27.41407 0.18977   1.000 14.92763 ? 15  TYR   A O   1 
ATOM   113  C CB  . TYR   A 1 36  ? -1.51242  -24.70416 -1.06510  1.000 17.31208 ? 15  TYR   A CB  1 
ATOM   114  C CG  . TYR   A 1 36  ? -2.88203  -24.38434 -1.61654  1.000 17.08680 ? 15  TYR   A CG  1 
ATOM   115  C CD1 . TYR   A 1 36  ? -3.49484  -23.16572 -1.35184  1.000 14.01754 ? 15  TYR   A CD1 1 
ATOM   116  C CD2 . TYR   A 1 36  ? -3.56395  -25.30423 -2.40125  1.000 16.49392 ? 15  TYR   A CD2 1 
ATOM   117  C CE1 . TYR   A 1 36  ? -4.74893  -22.87308 -1.85652  1.000 13.39809 ? 15  TYR   A CE1 1 
ATOM   118  C CE2 . TYR   A 1 36  ? -4.81755  -25.02202 -2.90637  1.000 20.16692 ? 15  TYR   A CE2 1 
ATOM   119  C CZ  . TYR   A 1 36  ? -5.40481  -23.80649 -2.63209  1.000 14.07696 ? 15  TYR   A CZ  1 
ATOM   120  O OH  . TYR   A 1 36  ? -6.65122  -23.52587 -3.13943  1.000 12.15314 ? 15  TYR   A OH  1 
ATOM   121  N N   . TYR   A 1 37  ? -3.31628  -26.31163 1.43632   1.000 14.02886 ? 16  TYR   A N   1 
ATOM   122  C CA  . TYR   A 1 37  ? -4.04598  -27.51115 1.83051   1.000 14.79630 ? 16  TYR   A CA  1 
ATOM   123  C C   . TYR   A 1 37  ? -5.37203  -27.57293 1.09197   1.000 13.86439 ? 16  TYR   A C   1 
ATOM   124  O O   . TYR   A 1 37  ? -6.15356  -26.61321 1.16804   1.000 14.68598 ? 16  TYR   A O   1 
ATOM   125  C CB  . TYR   A 1 37  ? -4.28798  -27.52859 3.33919   1.000 10.81446 ? 16  TYR   A CB  1 
ATOM   126  C CG  . TYR   A 1 37  ? -3.03394  -27.60952 4.17822   1.000 20.26225 ? 16  TYR   A CG  1 
ATOM   127  C CD1 . TYR   A 1 37  ? -2.46067  -28.83438 4.49459   1.000 21.87279 ? 16  TYR   A CD1 1 
ATOM   128  C CD2 . TYR   A 1 37  ? -2.43281  -26.45878 4.66940   1.000 18.31413 ? 16  TYR   A CD2 1 
ATOM   129  C CE1 . TYR   A 1 37  ? -1.31692  -28.90933 5.26679   1.000 23.76032 ? 16  TYR   A CE1 1 
ATOM   130  C CE2 . TYR   A 1 37  ? -1.29124  -26.52418 5.44113   1.000 22.57499 ? 16  TYR   A CE2 1 
ATOM   131  C CZ  . TYR   A 1 37  ? -0.73668  -27.74948 5.73643   1.000 25.84208 ? 16  TYR   A CZ  1 
ATOM   132  O OH  . TYR   A 1 37  ? 0.40172   -27.80980 6.50597   1.000 24.06000 ? 16  TYR   A OH  1 
ATOM   133  N N   . PRO   A 1 38  ? -5.67261  -28.65658 0.37513   1.000 14.95096 ? 17  PRO   A N   1 
ATOM   134  C CA  . PRO   A 1 38  ? -7.01863  -28.81154 -0.18573  1.000 12.29092 ? 17  PRO   A CA  1 
ATOM   135  C C   . PRO   A 1 38  ? -8.05649  -28.84013 0.92475   1.000 12.49614 ? 17  PRO   A C   1 
ATOM   136  O O   . PRO   A 1 38  ? -7.79272  -29.29827 2.03837   1.000 16.45535 ? 17  PRO   A O   1 
ATOM   137  C CB  . PRO   A 1 38  ? -6.94830  -30.15437 -0.92428  1.000 16.49144 ? 17  PRO   A CB  1 
ATOM   138  C CG  . PRO   A 1 38  ? -5.49419  -30.36601 -1.19405  1.000 17.87630 ? 17  PRO   A CG  1 
ATOM   139  C CD  . PRO   A 1 38  ? -4.77560  -29.75490 -0.02324  1.000 18.36608 ? 17  PRO   A CD  1 
ATOM   140  N N   . GLN   A 1 39  ? -9.24676  -28.32215 0.61221   1.000 15.64147 ? 18  GLN   A N   1 
ATOM   141  C CA  . GLN   A 1 39  ? -10.29905 -28.22752 1.61878   1.000 15.33685 ? 18  GLN   A CA  1 
ATOM   142  C C   . GLN   A 1 39  ? -10.70781 -29.60047 2.13986   1.000 16.91423 ? 18  GLN   A C   1 
ATOM   143  O O   . GLN   A 1 39  ? -11.05956 -29.73622 3.31740   1.000 19.09646 ? 18  GLN   A O   1 
ATOM   144  C CB  . GLN   A 1 39  ? -11.50568 -27.48655 1.03967   1.000 14.68753 ? 18  GLN   A CB  1 
ATOM   145  C CG  . GLN   A 1 39  ? -12.65815 -27.26010 2.01495   1.000 9.97838  ? 18  GLN   A CG  1 
ATOM   146  C CD  . GLN   A 1 39  ? -12.42682 -26.09146 2.96279   1.000 18.75235 ? 18  GLN   A CD  1 
ATOM   147  O OE1 . GLN   A 1 39  ? -11.29225 -25.67629 3.20140   1.000 14.19197 ? 18  GLN   A OE1 1 
ATOM   148  N NE2 . GLN   A 1 39  ? -13.51269 -25.55023 3.50235   1.000 14.42744 ? 18  GLN   A NE2 1 
ATOM   149  N N   . THR   A 1 40  ? -10.66790 -30.62694 1.28572   1.000 14.52198 ? 19  THR   A N   1 
ATOM   150  C CA  . THR   A 1 40  ? -10.97381 -31.97955 1.74215   1.000 17.45608 ? 19  THR   A CA  1 
ATOM   151  C C   . THR   A 1 40  ? -9.95287  -32.45784 2.76735   1.000 17.41516 ? 19  THR   A C   1 
ATOM   152  O O   . THR   A 1 40  ? -10.30379 -33.15797 3.72455   1.000 13.60184 ? 19  THR   A O   1 
ATOM   153  C CB  . THR   A 1 40  ? -11.02532 -32.93996 0.55360   1.000 17.10031 ? 19  THR   A CB  1 
ATOM   154  O OG1 . THR   A 1 40  ? -9.80326  -32.85040 -0.18827  1.000 23.67273 ? 19  THR   A OG1 1 
ATOM   155  C CG2 . THR   A 1 40  ? -12.18948 -32.59539 -0.35904  1.000 12.80584 ? 19  THR   A CG2 1 
ATOM   156  N N   . VAL   A 1 41  ? -8.68172  -32.09754 2.57515   1.000 14.21070 ? 20  VAL   A N   1 
ATOM   157  C CA  . VAL   A 1 41  ? -7.64387  -32.45419 3.53978   1.000 21.67221 ? 20  VAL   A CA  1 
ATOM   158  C C   . VAL   A 1 41  ? -7.89404  -31.76645 4.87637   1.000 20.24544 ? 20  VAL   A C   1 
ATOM   159  O O   . VAL   A 1 41  ? -7.74978  -32.37733 5.94277   1.000 21.59257 ? 20  VAL   A O   1 
ATOM   160  C CB  . VAL   A 1 41  ? -6.25307  -32.10776 2.97768   1.000 14.29854 ? 20  VAL   A CB  1 
ATOM   161  C CG1 . VAL   A 1 41  ? -5.17031  -32.43598 3.99645   1.000 24.90004 ? 20  VAL   A CG1 1 
ATOM   162  C CG2 . VAL   A 1 41  ? -6.00865  -32.85006 1.67684   1.000 23.97908 ? 20  VAL   A CG2 1 
ATOM   163  N N   . LEU   A 1 42  ? -8.25594  -30.48115 4.84275   1.000 13.86905 ? 21  LEU   A N   1 
ATOM   164  C CA  . LEU   A 1 42  ? -8.56419  -29.76762 6.07882   1.000 18.80145 ? 21  LEU   A CA  1 
ATOM   165  C C   . LEU   A 1 42  ? -9.79764  -30.34858 6.75902   1.000 15.11604 ? 21  LEU   A C   1 
ATOM   166  O O   . LEU   A 1 42  ? -9.82296  -30.50656 7.98569   1.000 14.86179 ? 21  LEU   A O   1 
ATOM   167  C CB  . LEU   A 1 42  ? -8.75315  -28.27716 5.79049   1.000 12.81269 ? 21  LEU   A CB  1 
ATOM   168  C CG  . LEU   A 1 42  ? -7.51429  -27.56190 5.24613   1.000 20.31422 ? 21  LEU   A CG  1 
ATOM   169  C CD1 . LEU   A 1 42  ? -7.84919  -26.16308 4.74257   1.000 11.66137 ? 21  LEU   A CD1 1 
ATOM   170  C CD2 . LEU   A 1 42  ? -6.43428  -27.50542 6.31998   1.000 17.68579 ? 21  LEU   A CD2 1 
ATOM   171  N N   . ALA   A 1 43  ? -10.83018 -30.67649 5.97748   1.000 22.80388 ? 22  ALA   A N   1 
ATOM   172  C CA  . ALA   A 1 43  ? -12.01578 -31.31211 6.54400   1.000 22.59979 ? 22  ALA   A CA  1 
ATOM   173  C C   . ALA   A 1 43  ? -11.67193 -32.66065 7.16371   1.000 16.93303 ? 22  ALA   A C   1 
ATOM   174  O O   . ALA   A 1 43  ? -12.18340 -33.01010 8.23431   1.000 17.65171 ? 22  ALA   A O   1 
ATOM   175  C CB  . ALA   A 1 43  ? -13.08995 -31.47392 5.46782   1.000 14.47456 ? 22  ALA   A CB  1 
ATOM   176  N N   . ALA   A 1 44  ? -10.80810 -33.43276 6.49932   1.000 19.28847 ? 23  ALA   A N   1 
ATOM   177  C CA  . ALA   A 1 44  ? -10.38386 -34.71870 7.04312   1.000 22.37813 ? 23  ALA   A CA  1 
ATOM   178  C C   . ALA   A 1 44  ? -9.63546  -34.54369 8.35801   1.000 25.87766 ? 23  ALA   A C   1 
ATOM   179  O O   . ALA   A 1 44  ? -9.79849  -35.34590 9.28562   1.000 23.88718 ? 23  ALA   A O   1 
ATOM   180  C CB  . ALA   A 1 44  ? -9.51146  -35.45478 6.02594   1.000 21.18837 ? 23  ALA   A CB  1 
ATOM   181  N N   . ALA   A 1 45  ? -8.79905  -33.50625 8.45172   1.000 17.03024 ? 24  ALA   A N   1 
ATOM   182  C CA  . ALA   A 1 45  ? -8.04306  -33.27452 9.67801   1.000 20.77045 ? 24  ALA   A CA  1 
ATOM   183  C C   . ALA   A 1 45  ? -8.96600  -32.97763 10.85375  1.000 21.63058 ? 24  ALA   A C   1 
ATOM   184  O O   . ALA   A 1 45  ? -8.76016  -33.49554 11.95787  1.000 23.75972 ? 24  ALA   A O   1 
ATOM   185  C CB  . ALA   A 1 45  ? -7.04863  -32.13263 9.47383   1.000 19.04775 ? 24  ALA   A CB  1 
ATOM   186  N N   . LEU   A 1 46  ? -9.98861  -32.14429 10.64020  1.000 14.55876 ? 25  LEU   A N   1 
ATOM   187  C CA  . LEU   A 1 46  ? -10.92173 -31.84151 11.72195  1.000 23.41302 ? 25  LEU   A CA  1 
ATOM   188  C C   . LEU   A 1 46  ? -11.72616 -33.07274 12.12346  1.000 24.80912 ? 25  LEU   A C   1 
ATOM   189  O O   . LEU   A 1 46  ? -11.97404 -33.29454 13.31423  1.000 23.67289 ? 25  LEU   A O   1 
ATOM   190  C CB  . LEU   A 1 46  ? -11.85567 -30.70080 11.31993  1.000 17.16788 ? 25  LEU   A CB  1 
ATOM   191  C CG  . LEU   A 1 46  ? -12.75812 -30.19734 12.45110  1.000 23.84123 ? 25  LEU   A CG  1 
ATOM   192  C CD1 . LEU   A 1 46  ? -11.92830 -29.76885 13.65837  1.000 23.77357 ? 25  LEU   A CD1 1 
ATOM   193  C CD2 . LEU   A 1 46  ? -13.65082 -29.06334 11.97849  1.000 24.05378 ? 25  LEU   A CD2 1 
ATOM   194  N N   . ARG   A 1 47  ? -12.15059 -33.87913 11.14546  1.000 24.67273 ? 26  ARG   A N   1 
ATOM   195  C CA  . ARG   A 1 47  ? -12.85932 -35.11621 11.46323  1.000 27.34238 ? 26  ARG   A CA  1 
ATOM   196  C C   . ARG   A 1 47  ? -11.98890 -36.04059 12.30299  1.000 25.47644 ? 26  ARG   A C   1 
ATOM   197  O O   . ARG   A 1 47  ? -12.47194 -36.67361 13.24921  1.000 24.97912 ? 26  ARG   A O   1 
ATOM   198  C CB  . ARG   A 1 47  ? -13.28936 -35.82969 10.18075  1.000 24.00009 ? 26  ARG   A CB  1 
ATOM   199  C CG  . ARG   A 1 47  ? -14.36935 -35.13031 9.37426   1.000 29.41790 ? 26  ARG   A CG  1 
ATOM   200  C CD  . ARG   A 1 47  ? -15.12468 -36.13335 8.50374   1.000 27.06003 ? 26  ARG   A CD  1 
ATOM   201  N NE  . ARG   A 1 47  ? -14.25377 -36.77834 7.52536   1.000 31.74300 ? 26  ARG   A NE  1 
ATOM   202  C CZ  . ARG   A 1 47  ? -13.70628 -36.17441 6.47764   1.000 35.38428 ? 26  ARG   A CZ  1 
ATOM   203  N NH1 . ARG   A 1 47  ? -13.94775 -34.90177 6.20504   1.000 28.60811 ? 26  ARG   A NH1 1 
ATOM   204  N NH2 . ARG   A 1 47  ? -12.89939 -36.86740 5.67870   1.000 27.84278 ? 26  ARG   A NH2 1 
ATOM   205  N N   . ARG   A 1 48  ? -10.70092 -36.13313 11.96293  1.000 25.92135 ? 27  ARG   A N   1 
ATOM   206  C CA  . ARG   A 1 48  ? -9.77973  -36.95962 12.73414  1.000 30.53791 ? 27  ARG   A CA  1 
ATOM   207  C C   . ARG   A 1 48  ? -9.72214  -36.50791 14.18665  1.000 33.73668 ? 27  ARG   A C   1 
ATOM   208  O O   . ARG   A 1 48  ? -9.62940  -37.33732 15.09907  1.000 34.18165 ? 27  ARG   A O   1 
ATOM   209  C CB  . ARG   A 1 48  ? -8.39041  -36.91538 12.09980  1.000 31.46709 ? 27  ARG   A CB  1 
ATOM   210  C CG  . ARG   A 1 48  ? -7.42867  -37.96733 12.61523  1.000 37.68931 ? 27  ARG   A CG  1 
ATOM   211  C CD  . ARG   A 1 48  ? -6.27366  -38.15342 11.64766  1.000 49.87940 ? 27  ARG   A CD  1 
ATOM   212  N NE  . ARG   A 1 48  ? -5.58829  -36.89434 11.38127  1.000 55.81499 ? 27  ARG   A NE  1 
ATOM   213  C CZ  . ARG   A 1 48  ? -4.44405  -36.78791 10.71987  1.000 57.90402 ? 27  ARG   A CZ  1 
ATOM   214  N NH1 . ARG   A 1 48  ? -3.82249  -37.85184 10.23782  1.000 50.74338 ? 27  ARG   A NH1 1 
ATOM   215  N NH2 . ARG   A 1 48  ? -3.91066  -35.58343 10.53635  1.000 52.44644 ? 27  ARG   A NH2 1 
ATOM   216  N N   . PHE   A 1 49  ? -9.77699  -35.19492 14.42168  1.000 35.00426 ? 28  PHE   A N   1 
ATOM   217  C CA  . PHE   A 1 49  ? -9.82171  -34.69209 15.79064  1.000 33.86121 ? 28  PHE   A CA  1 
ATOM   218  C C   . PHE   A 1 49  ? -11.08825 -35.14887 16.50280  1.000 29.64668 ? 28  PHE   A C   1 
ATOM   219  O O   . PHE   A 1 49  ? -11.03221 -35.64965 17.63047  1.000 35.60774 ? 28  PHE   A O   1 
ATOM   220  C CB  . PHE   A 1 49  ? -9.72043  -33.16677 15.79903  1.000 31.18402 ? 28  PHE   A CB  1 
ATOM   221  C CG  . PHE   A 1 49  ? -9.78113  -32.56787 17.17612  1.000 24.26461 ? 28  PHE   A CG  1 
ATOM   222  C CD1 . PHE   A 1 49  ? -8.63643  -32.45589 17.94722  1.000 33.32875 ? 28  PHE   A CD1 1 
ATOM   223  C CD2 . PHE   A 1 49  ? -10.98141 -32.10908 17.69692  1.000 29.68923 ? 28  PHE   A CD2 1 
ATOM   224  C CE1 . PHE   A 1 49  ? -8.68673  -31.90814 19.21504  1.000 27.35761 ? 28  PHE   A CE1 1 
ATOM   225  C CE2 . PHE   A 1 49  ? -11.03752 -31.55871 18.96559  1.000 34.31517 ? 28  PHE   A CE2 1 
ATOM   226  C CZ  . PHE   A 1 49  ? -9.88794  -31.45936 19.72406  1.000 34.10609 ? 28  PHE   A CZ  1 
ATOM   227  N N   . PHE   A 1 50  ? -12.24458 -34.98094 15.85786  1.000 34.41798 ? 29  PHE   A N   1 
ATOM   228  C CA  . PHE   A 1 50  ? -13.49391 -35.45026 16.44858  1.000 34.66504 ? 29  PHE   A CA  1 
ATOM   229  C C   . PHE   A 1 50  ? -13.44321 -36.94938 16.71307  1.000 39.95469 ? 29  PHE   A C   1 
ATOM   230  O O   . PHE   A 1 50  ? -13.88508 -37.41913 17.76859  1.000 38.33411 ? 29  PHE   A O   1 
ATOM   231  C CB  . PHE   A 1 50  ? -14.67289 -35.11392 15.53300  1.000 37.08469 ? 29  PHE   A CB  1 
ATOM   232  C CG  . PHE   A 1 50  ? -15.10540 -33.67077 15.57825  1.000 34.10862 ? 29  PHE   A CG  1 
ATOM   233  C CD1 . PHE   A 1 50  ? -14.18569 -32.64052 15.46432  1.000 32.85456 ? 29  PHE   A CD1 1 
ATOM   234  C CD2 . PHE   A 1 50  ? -16.44837 -33.35027 15.69808  1.000 31.17675 ? 29  PHE   A CD2 1 
ATOM   235  C CE1 . PHE   A 1 50  ? -14.59449 -31.31912 15.49875  1.000 32.46321 ? 29  PHE   A CE1 1 
ATOM   236  C CE2 . PHE   A 1 50  ? -16.86336 -32.03284 15.72667  1.000 32.62566 ? 29  PHE   A CE2 1 
ATOM   237  C CZ  . PHE   A 1 50  ? -15.93614 -31.01522 15.62822  1.000 29.71034 ? 29  PHE   A CZ  1 
ATOM   238  N N   . THR   A 1 51  ? -12.90040 -37.71364 15.76434  1.000 36.56799 ? 30  THR   A N   1 
ATOM   239  C CA  . THR   A 1 51  ? -12.87768 -39.16686 15.89247  1.000 37.94466 ? 30  THR   A CA  1 
ATOM   240  C C   . THR   A 1 51  ? -11.97179 -39.61011 17.03823  1.000 41.60455 ? 30  THR   A C   1 
ATOM   241  O O   . THR   A 1 51  ? -12.35083 -40.46532 17.84779  1.000 42.87523 ? 30  THR   A O   1 
ATOM   242  C CB  . THR   A 1 51  ? -12.42857 -39.79413 14.57040  1.000 36.95926 ? 30  THR   A CB  1 
ATOM   243  O OG1 . THR   A 1 51  ? -13.41409 -39.53661 13.56112  1.000 33.31137 ? 30  THR   A OG1 1 
ATOM   244  C CG2 . THR   A 1 51  ? -12.26132 -41.29657 14.72307  1.000 35.44963 ? 30  THR   A CG2 1 
ATOM   245  N N   . VAL   A 1 52  ? -10.77193 -39.03129 17.12769  1.000 37.91049 ? 31  VAL   A N   1 
ATOM   246  C CA  . VAL   A 1 52  ? -9.82150  -39.44231 18.15732  1.000 38.68129 ? 31  VAL   A CA  1 
ATOM   247  C C   . VAL   A 1 52  ? -10.32731 -39.06154 19.54490  1.000 47.71363 ? 31  VAL   A C   1 
ATOM   248  O O   . VAL   A 1 52  ? -10.21634 -39.84511 20.49598  1.000 55.26974 ? 31  VAL   A O   1 
ATOM   249  C CB  . VAL   A 1 52  ? -8.43218  -38.84519 17.86872  1.000 39.39418 ? 31  VAL   A CB  1 
ATOM   250  C CG1 . VAL   A 1 52  ? -7.52941  -38.98567 19.08409  1.000 48.00046 ? 31  VAL   A CG1 1 
ATOM   251  C CG2 . VAL   A 1 52  ? -7.80983  -39.52806 16.65915  1.000 43.94476 ? 31  VAL   A CG2 1 
ATOM   252  N N   . MET   A 1 53  ? -10.90364 -37.86694 19.68386  1.000 46.66962 ? 32  MET   A N   1 
ATOM   253  C CA  . MET   A 1 53  ? -11.41111 -37.40870 20.97223  1.000 44.51420 ? 32  MET   A CA  1 
ATOM   254  C C   . MET   A 1 53  ? -12.78733 -37.97084 21.30886  1.000 48.41162 ? 32  MET   A C   1 
ATOM   255  O O   . MET   A 1 53  ? -13.31508 -37.65371 22.38056  1.000 56.61058 ? 32  MET   A O   1 
ATOM   256  C CB  . MET   A 1 53  ? -11.45554 -35.87355 21.01275  1.000 42.64005 ? 32  MET   A CB  1 
ATOM   257  C CG  . MET   A 1 53  ? -10.17318 -35.17774 20.55399  1.000 37.13421 ? 32  MET   A CG  1 
ATOM   258  S SD  . MET   A 1 53  ? -8.64149  -35.51812 21.46152  1.000 54.47237 ? 32  MET   A SD  1 
ATOM   259  C CE  . MET   A 1 53  ? -9.22310  -35.92805 23.10945  1.000 41.33829 ? 32  MET   A CE  1 
ATOM   260  N N   . GLU   A 1 54  ? -13.37459 -38.78800 20.43102  1.000 44.37664 ? 33  GLU   A N   1 
ATOM   261  C CA  . GLU   A 1 54  ? -14.68309 -39.40214 20.67298  1.000 51.40380 ? 33  GLU   A CA  1 
ATOM   262  C C   . GLU   A 1 54  ? -15.74087 -38.35045 20.99848  1.000 49.13357 ? 33  GLU   A C   1 
ATOM   263  O O   . GLU   A 1 54  ? -16.55340 -38.51236 21.91200  1.000 46.63332 ? 33  GLU   A O   1 
ATOM   264  C CB  . GLU   A 1 54  ? -14.60110 -40.45688 21.77874  1.000 46.13894 ? 33  GLU   A CB  1 
ATOM   265  C CG  . GLU   A 1 54  ? -14.05214 -41.79627 21.31411  1.000 52.94495 ? 33  GLU   A CG  1 
ATOM   266  C CD  . GLU   A 1 54  ? -13.10893 -42.42140 22.32184  1.000 56.82942 ? 33  GLU   A CD  1 
ATOM   267  O OE1 . GLU   A 1 54  ? -13.39982 -42.34455 23.53399  1.000 53.29388 ? 33  GLU   A OE1 1 
ATOM   268  O OE2 . GLU   A 1 54  ? -12.08094 -42.99366 21.90135  1.000 49.84602 ? 33  GLU   A OE2 1 
ATOM   269  N N   . LEU   A 1 55  ? -15.72388 -37.25572 20.24333  1.000 43.79047 ? 34  LEU   A N   1 
ATOM   270  C CA  . LEU   A 1 55  ? -16.70446 -36.19284 20.41557  1.000 41.62189 ? 34  LEU   A CA  1 
ATOM   271  C C   . LEU   A 1 55  ? -18.02131 -36.62173 19.78029  1.000 35.06964 ? 34  LEU   A C   1 
ATOM   272  O O   . LEU   A 1 55  ? -18.06523 -36.94424 18.58788  1.000 37.16480 ? 34  LEU   A O   1 
ATOM   273  C CB  . LEU   A 1 55  ? -16.19259 -34.89560 19.79401  1.000 44.14053 ? 34  LEU   A CB  1 
ATOM   274  C CG  . LEU   A 1 55  ? -14.93374 -34.31538 20.44405  1.000 39.06466 ? 34  LEU   A CG  1 
ATOM   275  C CD1 . LEU   A 1 55  ? -14.56628 -32.97908 19.82049  1.000 37.77297 ? 34  LEU   A CD1 1 
ATOM   276  C CD2 . LEU   A 1 55  ? -15.12312 -34.17546 21.94778  1.000 39.21299 ? 34  LEU   A CD2 1 
ATOM   277  N N   . ASP   A 1 56  ? -19.09174 -36.63034 20.57232  1.000 41.66474 ? 35  ASP   A N   1 
ATOM   278  C CA  . ASP   A 1 56  ? -20.39489 -37.09166 20.09577  1.000 41.87513 ? 35  ASP   A CA  1 
ATOM   279  C C   . ASP   A 1 56  ? -21.05540 -35.94848 19.33573  1.000 38.28916 ? 35  ASP   A C   1 
ATOM   280  O O   . ASP   A 1 56  ? -21.73021 -35.09123 19.90851  1.000 36.06199 ? 35  ASP   A O   1 
ATOM   281  C CB  . ASP   A 1 56  ? -21.25828 -37.57324 21.25572  1.000 34.71730 ? 35  ASP   A CB  1 
ATOM   282  C CG  . ASP   A 1 56  ? -22.70725 -37.79848 20.85475  1.000 50.83317 ? 35  ASP   A CG  1 
ATOM   283  O OD1 . ASP   A 1 56  ? -22.94958 -38.28628 19.72861  1.000 46.03835 ? 35  ASP   A OD1 1 
ATOM   284  O OD2 . ASP   A 1 56  ? -23.60443 -37.49780 21.67067  1.000 55.86132 ? 35  ASP   A OD2 1 
ATOM   285  N N   . PHE   A 1 57  ? -20.85092 -35.93815 18.02228  1.000 35.43084 ? 36  PHE   A N   1 
ATOM   286  C CA  . PHE   A 1 57  ? -21.42734 -34.92522 17.15274  1.000 35.45623 ? 36  PHE   A CA  1 
ATOM   287  C C   . PHE   A 1 57  ? -21.42153 -35.46880 15.73378  1.000 34.89073 ? 36  PHE   A C   1 
ATOM   288  O O   . PHE   A 1 57  ? -20.51577 -36.21286 15.34636  1.000 34.81257 ? 36  PHE   A O   1 
ATOM   289  C CB  . PHE   A 1 57  ? -20.65387 -33.60348 17.23147  1.000 39.27067 ? 36  PHE   A CB  1 
ATOM   290  C CG  . PHE   A 1 57  ? -21.38768 -32.43373 16.63888  1.000 39.44997 ? 36  PHE   A CG  1 
ATOM   291  C CD1 . PHE   A 1 57  ? -22.38825 -31.79439 17.35117  1.000 34.05889 ? 36  PHE   A CD1 1 
ATOM   292  C CD2 . PHE   A 1 57  ? -21.07529 -31.97282 15.37075  1.000 36.10647 ? 36  PHE   A CD2 1 
ATOM   293  C CE1 . PHE   A 1 57  ? -23.06329 -30.71727 16.81018  1.000 41.76670 ? 36  PHE   A CE1 1 
ATOM   294  C CE2 . PHE   A 1 57  ? -21.74699 -30.89733 14.82318  1.000 23.45724 ? 36  PHE   A CE2 1 
ATOM   295  C CZ  . PHE   A 1 57  ? -22.74283 -30.26851 15.54327  1.000 34.64943 ? 36  PHE   A CZ  1 
ATOM   296  N N   . ASP   A 1 58  ? -22.44677 -35.09565 14.96958  1.000 38.63623 ? 37  ASP   A N   1 
ATOM   297  C CA  . ASP   A 1 58  ? -22.59511 -35.57726 13.60313  1.000 26.60598 ? 37  ASP   A CA  1 
ATOM   298  C C   . ASP   A 1 58  ? -21.36394 -35.16284 12.80121  1.000 41.18461 ? 37  ASP   A C   1 
ATOM   299  O O   . ASP   A 1 58  ? -21.12738 -33.96888 12.57811  1.000 33.58472 ? 37  ASP   A O   1 
ATOM   300  C CB  . ASP   A 1 58  ? -23.88484 -35.02181 12.98619  1.000 37.83634 ? 37  ASP   A CB  1 
ATOM   301  C CG  . ASP   A 1 58  ? -24.10781 -35.46899 11.54446  1.000 36.39578 ? 37  ASP   A CG  1 
ATOM   302  O OD1 . ASP   A 1 58  ? -23.16352 -35.94064 10.87660  1.000 39.43130 ? 37  ASP   A OD1 1 
ATOM   303  O OD2 . ASP   A 1 58  ? -25.25461 -35.33200 11.06679  1.000 49.95888 ? 37  ASP   A OD2 1 
ATOM   304  N N   . LEU   A 1 59  ? -20.57094 -36.14767 12.36815  1.000 37.03757 ? 38  LEU   A N   1 
ATOM   305  C CA  . LEU   A 1 59  ? -19.36456 -35.86195 11.59970  1.000 36.37416 ? 38  LEU   A CA  1 
ATOM   306  C C   . LEU   A 1 59  ? -19.67022 -35.24636 10.24271  1.000 33.23196 ? 38  LEU   A C   1 
ATOM   307  O O   . LEU   A 1 59  ? -18.79295 -34.60747 9.65334   1.000 31.09814 ? 38  LEU   A O   1 
ATOM   308  C CB  . LEU   A 1 59  ? -18.54391 -37.14010 11.41074  1.000 41.46455 ? 38  LEU   A CB  1 
ATOM   309  C CG  . LEU   A 1 59  ? -17.81146 -37.67761 12.64073  1.000 26.13395 ? 38  LEU   A CG  1 
ATOM   310  C CD1 . LEU   A 1 59  ? -16.93664 -38.86789 12.27897  1.000 28.05980 ? 38  LEU   A CD1 1 
ATOM   311  C CD2 . LEU   A 1 59  ? -16.98016 -36.57451 13.26393  1.000 34.79100 ? 38  LEU   A CD2 1 
ATOM   312  N N   . GLU   A 1 60  ? -20.88315 -35.42739 9.72876   1.000 31.30981 ? 39  GLU   A N   1 
ATOM   313  C CA  . GLU   A 1 60  ? -21.20766 -34.87884 8.42235   1.000 32.73462 ? 39  GLU   A CA  1 
ATOM   314  C C   . GLU   A 1 60  ? -21.56797 -33.40224 8.47950   1.000 25.97673 ? 39  GLU   A C   1 
ATOM   315  O O   . GLU   A 1 60  ? -21.70361 -32.77374 7.42392   1.000 31.71753 ? 39  GLU   A O   1 
ATOM   316  C CB  . GLU   A 1 60  ? -22.34567 -35.67328 7.78413   1.000 43.23852 ? 39  GLU   A CB  1 
ATOM   317  C CG  . GLU   A 1 60  ? -21.85019 -36.82796 6.93646   1.000 35.46722 ? 39  GLU   A CG  1 
ATOM   318  C CD  . GLU   A 1 60  ? -21.73273 -36.45279 5.47838   1.000 49.71567 ? 39  GLU   A CD  1 
ATOM   319  O OE1 . GLU   A 1 60  ? -22.49308 -35.56699 5.02901   1.000 48.75886 ? 39  GLU   A OE1 1 
ATOM   320  O OE2 . GLU   A 1 60  ? -20.85690 -37.01651 4.78754   1.000 53.98615 ? 39  GLU   A OE2 1 
ATOM   321  N N   . GLN   A 1 61  ? -21.73907 -32.84013 9.67852   1.000 28.95909 ? 40  GLN   A N   1 
ATOM   322  C CA  . GLN   A 1 61  ? -21.85245 -31.39138 9.80199   1.000 31.17287 ? 40  GLN   A CA  1 
ATOM   323  C C   . GLN   A 1 61  ? -20.55467 -30.71553 9.37917   1.000 29.50864 ? 40  GLN   A C   1 
ATOM   324  O O   . GLN   A 1 61  ? -20.57311 -29.65427 8.74415   1.000 20.61129 ? 40  GLN   A O   1 
ATOM   325  C CB  . GLN   A 1 61  ? -22.21604 -31.01295 11.23859  1.000 23.33914 ? 40  GLN   A CB  1 
ATOM   326  C CG  . GLN   A 1 61  ? -23.71139 -31.00360 11.54826  1.000 31.03671 ? 40  GLN   A CG  1 
ATOM   327  C CD  . GLN   A 1 61  ? -24.57028 -30.62684 10.35379  1.000 40.20401 ? 40  GLN   A CD  1 
ATOM   328  O OE1 . GLN   A 1 61  ? -24.77216 -29.44601 10.06797  1.000 37.66861 ? 40  GLN   A OE1 1 
ATOM   329  N NE2 . GLN   A 1 61  ? -25.10222 -31.63198 9.66447   1.000 38.27491 ? 40  GLN   A NE2 1 
ATOM   330  N N   . ILE   A 1 62  ? -19.41633 -31.32206 9.72614   1.000 21.22698 ? 41  ILE   A N   1 
ATOM   331  C CA  . ILE   A 1 62  ? -18.11891 -30.79695 9.30845   1.000 17.61923 ? 41  ILE   A CA  1 
ATOM   332  C C   . ILE   A 1 62  ? -18.00410 -30.80805 7.78964   1.000 22.15758 ? 41  ILE   A C   1 
ATOM   333  O O   . ILE   A 1 62  ? -17.55727 -29.83240 7.17475   1.000 14.75738 ? 41  ILE   A O   1 
ATOM   334  C CB  . ILE   A 1 62  ? -16.98063 -31.60308 9.96089   1.000 25.11223 ? 41  ILE   A CB  1 
ATOM   335  C CG1 . ILE   A 1 62  ? -17.15016 -31.63911 11.48269  1.000 26.38018 ? 41  ILE   A CG1 1 
ATOM   336  C CG2 . ILE   A 1 62  ? -15.62024 -31.04846 9.55117   1.000 22.30378 ? 41  ILE   A CG2 1 
ATOM   337  C CD1 . ILE   A 1 62  ? -16.19373 -32.58175 12.18173  1.000 33.76884 ? 41  ILE   A CD1 1 
ATOM   338  N N   . ASP   A 1 63  ? -18.40173 -31.91751 7.16267   1.000 23.18436 ? 42  ASP   A N   1 
ATOM   339  C CA  . ASP   A 1 63  ? -18.26089 -32.03921 5.71541   1.000 23.32380 ? 42  ASP   A CA  1 
ATOM   340  C C   . ASP   A 1 63  ? -19.13567 -31.03181 4.97930   1.000 18.75176 ? 42  ASP   A C   1 
ATOM   341  O O   . ASP   A 1 63  ? -18.68797 -30.41319 4.00722   1.000 18.30135 ? 42  ASP   A O   1 
ATOM   342  C CB  . ASP   A 1 63  ? -18.59072 -33.46453 5.27081   1.000 23.07870 ? 42  ASP   A CB  1 
ATOM   343  C CG  . ASP   A 1 63  ? -17.48632 -34.44883 5.60549   1.000 29.50032 ? 42  ASP   A CG  1 
ATOM   344  O OD1 . ASP   A 1 63  ? -16.31632 -34.02211 5.70722   1.000 28.35089 ? 42  ASP   A OD1 1 
ATOM   345  O OD2 . ASP   A 1 63  ? -17.78792 -35.65215 5.75694   1.000 35.68165 ? 42  ASP   A OD2 1 
ATOM   346  N N   . ARG   A 1 64  ? -20.38549 -30.85364 5.41871   1.000 21.87845 ? 43  ARG   A N   1 
ATOM   347  C CA  . ARG   A 1 64  ? -21.27249 -29.92661 4.72039   1.000 24.79565 ? 43  ARG   A CA  1 
ATOM   348  C C   . ARG   A 1 64  ? -20.76855 -28.49121 4.80560   1.000 17.39711 ? 43  ARG   A C   1 
ATOM   349  O O   . ARG   A 1 64  ? -20.78148 -27.76517 3.80584   1.000 22.48080 ? 43  ARG   A O   1 
ATOM   350  C CB  . ARG   A 1 64  ? -22.70309 -30.02721 5.25659   1.000 30.73517 ? 43  ARG   A CB  1 
ATOM   351  C CG  . ARG   A 1 64  ? -23.51670 -31.13814 4.61107   1.000 29.58951 ? 43  ARG   A CG  1 
ATOM   352  C CD  . ARG   A 1 64  ? -24.94338 -31.19307 5.13079   1.000 32.02743 ? 43  ARG   A CD  1 
ATOM   353  N NE  . ARG   A 1 64  ? -25.48038 -32.54828 5.10311   1.000 29.06072 ? 43  ARG   A NE  1 
ATOM   354  C CZ  . ARG   A 1 64  ? -26.68028 -32.88799 5.55314   1.000 29.46305 ? 43  ARG   A CZ  1 
ATOM   355  N NH1 . ARG   A 1 64  ? -27.50562 -31.99006 6.06605   1.000 32.21142 ? 43  ARG   A NH1 1 
ATOM   356  N NH2 . ARG   A 1 64  ? -27.06388 -34.15963 5.48132   1.000 28.28394 ? 43  ARG   A NH2 1 
ATOM   357  N N   . PHE   A 1 65  ? -20.30835 -28.06251 5.98081   1.000 20.82666 ? 44  PHE   A N   1 
ATOM   358  C CA  . PHE   A 1 65  ? -19.87111 -26.67623 6.11078   1.000 20.22310 ? 44  PHE   A CA  1 
ATOM   359  C C   . PHE   A 1 65  ? -18.52910 -26.43725 5.42736   1.000 19.96290 ? 44  PHE   A C   1 
ATOM   360  O O   . PHE   A 1 65  ? -18.30773 -25.36286 4.85750   1.000 20.70351 ? 44  PHE   A O   1 
ATOM   361  C CB  . PHE   A 1 65  ? -19.83149 -26.26848 7.58086   1.000 20.06540 ? 44  PHE   A CB  1 
ATOM   362  C CG  . PHE   A 1 65  ? -21.18736 -25.95289 8.14542   1.000 23.84042 ? 44  PHE   A CG  1 
ATOM   363  C CD1 . PHE   A 1 65  ? -21.87893 -24.83062 7.71952   1.000 23.65243 ? 44  PHE   A CD1 1 
ATOM   364  C CD2 . PHE   A 1 65  ? -21.77680 -26.78191 9.08244   1.000 24.05113 ? 44  PHE   A CD2 1 
ATOM   365  C CE1 . PHE   A 1 65  ? -23.13372 -24.53526 8.22846   1.000 23.21634 ? 44  PHE   A CE1 1 
ATOM   366  C CE2 . PHE   A 1 65  ? -23.02932 -26.49513 9.59234   1.000 28.43330 ? 44  PHE   A CE2 1 
ATOM   367  C CZ  . PHE   A 1 65  ? -23.70895 -25.37078 9.16534   1.000 24.52376 ? 44  PHE   A CZ  1 
ATOM   368  N N   . PHE   A 1 66  ? -17.62221 -27.41755 5.46102   1.000 17.45234 ? 45  PHE   A N   1 
ATOM   369  C CA  . PHE   A 1 66  ? -16.39296 -27.27486 4.68704   1.000 17.55151 ? 45  PHE   A CA  1 
ATOM   370  C C   . PHE   A 1 66  ? -16.67850 -27.28644 3.19087   1.000 16.11477 ? 45  PHE   A C   1 
ATOM   371  O O   . PHE   A 1 66  ? -15.93497 -26.67955 2.41239   1.000 19.24805 ? 45  PHE   A O   1 
ATOM   372  C CB  . PHE   A 1 66  ? -15.38791 -28.37283 5.05001   1.000 15.96727 ? 45  PHE   A CB  1 
ATOM   373  C CG  . PHE   A 1 66  ? -14.57021 -28.07098 6.28231   1.000 14.62200 ? 45  PHE   A CG  1 
ATOM   374  C CD1 . PHE   A 1 66  ? -15.18023 -27.87676 7.51288   1.000 12.02599 ? 45  PHE   A CD1 1 
ATOM   375  C CD2 . PHE   A 1 66  ? -13.19267 -27.95880 6.20203   1.000 16.49013 ? 45  PHE   A CD2 1 
ATOM   376  C CE1 . PHE   A 1 66  ? -14.42804 -27.59176 8.64062   1.000 17.14506 ? 45  PHE   A CE1 1 
ATOM   377  C CE2 . PHE   A 1 66  ? -12.43539 -27.67289 7.32570   1.000 15.31858 ? 45  PHE   A CE2 1 
ATOM   378  C CZ  . PHE   A 1 66  ? -13.05638 -27.49042 8.54841   1.000 11.42147 ? 45  PHE   A CZ  1 
ATOM   379  N N   . THR   A 1 67  ? -17.75070 -27.96031 2.77371   1.000 23.32144 ? 46  THR   A N   1 
ATOM   380  C CA  . THR   A 1 67  ? -18.11309 -27.99531 1.36168   1.000 20.22247 ? 46  THR   A CA  1 
ATOM   381  C C   . THR   A 1 67  ? -18.90369 -26.75774 0.95267   1.000 21.44325 ? 46  THR   A C   1 
ATOM   382  O O   . THR   A 1 67  ? -18.65625 -26.18379 -0.11459  1.000 15.26160 ? 46  THR   A O   1 
ATOM   383  C CB  . THR   A 1 67  ? -18.92458 -29.25823 1.05966   1.000 23.25742 ? 46  THR   A CB  1 
ATOM   384  O OG1 . THR   A 1 67  ? -18.13410 -30.41767 1.34978   1.000 17.85505 ? 46  THR   A OG1 1 
ATOM   385  C CG2 . THR   A 1 67  ? -19.35054 -29.29341 -0.40430  1.000 16.80649 ? 46  THR   A CG2 1 
ATOM   386  N N   . ASN   A 1 68  ? -19.85079 -26.32887 1.78787   1.000 13.42083 ? 47  ASN   A N   1 
ATOM   387  C CA  . ASN   A 1 68  ? -20.78534 -25.28266 1.39634   1.000 19.72885 ? 47  ASN   A CA  1 
ATOM   388  C C   . ASN   A 1 68  ? -20.18355 -23.88405 1.43692   1.000 18.83370 ? 47  ASN   A C   1 
ATOM   389  O O   . ASN   A 1 68  ? -20.80283 -22.95260 0.91166   1.000 22.67338 ? 47  ASN   A O   1 
ATOM   390  C CB  . ASN   A 1 68  ? -22.03448 -25.33559 2.27842   1.000 15.53746 ? 47  ASN   A CB  1 
ATOM   391  C CG  . ASN   A 1 68  ? -22.87854 -26.57030 2.01240   1.000 25.60873 ? 47  ASN   A CG  1 
ATOM   392  O OD1 . ASN   A 1 68  ? -22.68002 -27.26889 1.01545   1.000 24.43066 ? 47  ASN   A OD1 1 
ATOM   393  N ND2 . ASN   A 1 68  ? -23.82770 -26.84281 2.90030   1.000 25.50113 ? 47  ASN   A ND2 1 
ATOM   394  N N   . VAL   A 1 69  ? -19.00293 -23.70530 2.03579   1.000 23.56011 ? 48  VAL   A N   1 
ATOM   395  C CA  . VAL   A 1 69  ? -18.30846 -22.42687 1.92255   1.000 18.11377 ? 48  VAL   A CA  1 
ATOM   396  C C   . VAL   A 1 69  ? -17.72893 -22.20933 0.53481   1.000 20.64947 ? 48  VAL   A C   1 
ATOM   397  O O   . VAL   A 1 69  ? -17.30425 -21.09148 0.22162   1.000 21.75286 ? 48  VAL   A O   1 
ATOM   398  C CB  . VAL   A 1 69  ? -17.18777 -22.29886 2.97476   1.000 16.55958 ? 48  VAL   A CB  1 
ATOM   399  C CG1 . VAL   A 1 69  ? -17.78209 -22.17468 4.37072   1.000 19.57311 ? 48  VAL   A CG1 1 
ATOM   400  C CG2 . VAL   A 1 69  ? -16.24584 -23.48759 2.89436   1.000 16.92943 ? 48  VAL   A CG2 1 
ATOM   401  N N   . LYS   A 1 70  ? -17.70252 -23.25194 -0.29996  1.000 16.35973 ? 49  LYS   A N   1 
ATOM   402  C CA  . LYS   A 1 70  ? -17.24665 -23.15824 -1.68824  1.000 17.53926 ? 49  LYS   A CA  1 
ATOM   403  C C   . LYS   A 1 70  ? -15.79277 -22.68942 -1.75814  1.000 17.27277 ? 49  LYS   A C   1 
ATOM   404  O O   . LYS   A 1 70  ? -15.44912 -21.73904 -2.46554  1.000 15.78050 ? 49  LYS   A O   1 
ATOM   405  C CB  . LYS   A 1 70  ? -18.16879 -22.24900 -2.50721  1.000 20.63255 ? 49  LYS   A CB  1 
ATOM   406  C CG  . LYS   A 1 70  ? -19.63026 -22.68416 -2.48623  1.000 19.68580 ? 49  LYS   A CG  1 
ATOM   407  C CD  . LYS   A 1 70  ? -20.39736 -22.20806 -3.71288  1.000 29.55066 ? 49  LYS   A CD  1 
ATOM   408  C CE  . LYS   A 1 70  ? -21.45869 -23.22304 -4.10950  1.000 26.17318 ? 49  LYS   A CE  1 
ATOM   409  N NZ  . LYS   A 1 70  ? -22.77126 -22.56667 -4.35935  1.000 35.04474 ? 49  LYS   A NZ  1 
ATOM   410  N N   . ILE   A 1 71  ? -14.93766 -23.37306 -1.00222  1.000 11.07682 ? 50  ILE   A N   1 
ATOM   411  C CA  . ILE   A 1 71  ? -13.50310 -23.12040 -0.96374  1.000 12.14080 ? 50  ILE   A CA  1 
ATOM   412  C C   . ILE   A 1 71  ? -12.79644 -24.39059 -1.41736  1.000 11.11963 ? 50  ILE   A C   1 
ATOM   413  O O   . ILE   A 1 71  ? -13.07982 -25.47811 -0.90256  1.000 13.40428 ? 50  ILE   A O   1 
ATOM   414  C CB  . ILE   A 1 71  ? -13.04339 -22.70536 0.44790   1.000 12.62894 ? 50  ILE   A CB  1 
ATOM   415  C CG1 . ILE   A 1 71  ? -13.68356 -21.37230 0.85210   1.000 10.24728 ? 50  ILE   A CG1 1 
ATOM   416  C CG2 . ILE   A 1 71  ? -11.52495 -22.62941 0.52533   1.000 11.04932 ? 50  ILE   A CG2 1 
ATOM   417  C CD1 . ILE   A 1 71  ? -13.49507 -21.01848 2.31815   1.000 13.73294 ? 50  ILE   A CD1 1 
ATOM   418  N N   . ASP   A 1 72  ? -11.89483 -24.25817 -2.39105  1.000 9.75853  ? 51  ASP   A N   1 
ATOM   419  C CA  . ASP   A 1 72  ? -11.16188 -25.41197 -2.89941  1.000 10.46505 ? 51  ASP   A CA  1 
ATOM   420  C C   . ASP   A 1 72  ? -9.91357  -25.72299 -2.08608  1.000 18.47212 ? 51  ASP   A C   1 
ATOM   421  O O   . ASP   A 1 72  ? -9.48307  -26.88142 -2.04397  1.000 17.40941 ? 51  ASP   A O   1 
ATOM   422  C CB  . ASP   A 1 72  ? -10.77058 -25.19071 -4.36295  1.000 11.38091 ? 51  ASP   A CB  1 
ATOM   423  C CG  . ASP   A 1 72  ? -11.97325 -25.14584 -5.29003  1.000 12.59875 ? 51  ASP   A CG  1 
ATOM   424  O OD1 . ASP   A 1 72  ? -13.02148 -25.73013 -4.94448  1.000 14.11561 ? 51  ASP   A OD1 1 
ATOM   425  O OD2 . ASP   A 1 72  ? -11.86856 -24.52398 -6.36508  1.000 19.51731 ? 51  ASP   A OD2 1 
ATOM   426  N N   . GLY   A 1 73  ? -9.32646  -24.72152 -1.44642  1.000 15.39311 ? 52  GLY   A N   1 
ATOM   427  C CA  . GLY   A 1 73  ? -8.14168  -24.93702 -0.64191  1.000 14.98087 ? 52  GLY   A CA  1 
ATOM   428  C C   . GLY   A 1 73  ? -7.76616  -23.65730 0.07106   1.000 13.71939 ? 52  GLY   A C   1 
ATOM   429  O O   . GLY   A 1 73  ? -8.24944  -22.56913 -0.26044  1.000 14.67305 ? 52  GLY   A O   1 
ATOM   430  N N   . ARG   A 1 74  ? -6.88932  -23.80831 1.06148   1.000 12.11083 ? 53  ARG   A N   1 
ATOM   431  C CA  . ARG   A 1 74  ? -6.46396  -22.68331 1.87925   1.000 9.85388  ? 53  ARG   A CA  1 
ATOM   432  C C   . ARG   A 1 74  ? -4.98687  -22.81561 2.21672   1.000 10.59828 ? 53  ARG   A C   1 
ATOM   433  O O   . ARG   A 1 74  ? -4.46050  -23.92293 2.34920   1.000 12.06877 ? 53  ARG   A O   1 
ATOM   434  C CB  . ARG   A 1 74  ? -7.28162  -22.59119 3.17413   1.000 9.10566  ? 53  ARG   A CB  1 
ATOM   435  C CG  . ARG   A 1 74  ? -8.74367  -22.21652 2.97556   1.000 9.55272  ? 53  ARG   A CG  1 
ATOM   436  C CD  . ARG   A 1 74  ? -9.48151  -22.20972 4.30354   1.000 13.11867 ? 53  ARG   A CD  1 
ATOM   437  N NE  . ARG   A 1 74  ? -9.97833  -23.53186 4.66011   1.000 11.56286 ? 53  ARG   A NE  1 
ATOM   438  C CZ  . ARG   A 1 74  ? -10.33920 -23.89000 5.88484   1.000 14.62809 ? 53  ARG   A CZ  1 
ATOM   439  N NH1 . ARG   A 1 74  ? -10.25055 -23.05209 6.90513   1.000 14.06767 ? 53  ARG   A NH1 1 
ATOM   440  N NH2 . ARG   A 1 74  ? -10.79967 -25.12020 6.09170   1.000 12.32578 ? 53  ARG   A NH2 1 
ATOM   441  N N   . TYR   A 1 75  ? -4.32449  -21.66940 2.35302   1.000 9.96439  ? 54  TYR   A N   1 
ATOM   442  C CA  . TYR   A 1 75  ? -2.95736  -21.61500 2.85189   1.000 12.69297 ? 54  TYR   A CA  1 
ATOM   443  C C   . TYR   A 1 75  ? -2.97791  -21.52134 4.37134   1.000 11.78580 ? 54  TYR   A C   1 
ATOM   444  O O   . TYR   A 1 75  ? -3.66101  -20.65945 4.93361   1.000 10.70132 ? 54  TYR   A O   1 
ATOM   445  C CB  . TYR   A 1 75  ? -2.20594  -20.41072 2.28283   1.000 9.03251  ? 54  TYR   A CB  1 
ATOM   446  C CG  . TYR   A 1 75  ? -1.87424  -20.46313 0.80706   1.000 9.24225  ? 54  TYR   A CG  1 
ATOM   447  C CD1 . TYR   A 1 75  ? -0.70759  -21.07177 0.36020   1.000 12.74783 ? 54  TYR   A CD1 1 
ATOM   448  C CD2 . TYR   A 1 75  ? -2.70615  -19.87139 -0.13406  1.000 12.64721 ? 54  TYR   A CD2 1 
ATOM   449  C CE1 . TYR   A 1 75  ? -0.38817  -21.10638 -0.98336  1.000 14.09078 ? 54  TYR   A CE1 1 
ATOM   450  C CE2 . TYR   A 1 75  ? -2.39338  -19.89903 -1.48146  1.000 12.08987 ? 54  TYR   A CE2 1 
ATOM   451  C CZ  . TYR   A 1 75  ? -1.23244  -20.51882 -1.89829  1.000 15.29326 ? 54  TYR   A CZ  1 
ATOM   452  O OH  . TYR   A 1 75  ? -0.91261  -20.55323 -3.23468  1.000 13.65284 ? 54  TYR   A OH  1 
ATOM   453  N N   . PHE   A 1 76  ? -2.22743  -22.40187 5.02943   1.000 9.77439  ? 55  PHE   A N   1 
ATOM   454  C CA  . PHE   A 1 76  ? -2.01142  -22.34457 6.47176   1.000 14.31508 ? 55  PHE   A CA  1 
ATOM   455  C C   . PHE   A 1 76  ? -0.53032  -22.10953 6.73201   1.000 18.24043 ? 55  PHE   A C   1 
ATOM   456  O O   . PHE   A 1 76  ? 0.30716   -22.93390 6.35019   1.000 16.34691 ? 55  PHE   A O   1 
ATOM   457  C CB  . PHE   A 1 76  ? -2.47148  -23.63146 7.16357   1.000 12.03146 ? 55  PHE   A CB  1 
ATOM   458  C CG  . PHE   A 1 76  ? -3.94817  -23.68473 7.45344   1.000 15.72402 ? 55  PHE   A CG  1 
ATOM   459  C CD1 . PHE   A 1 76  ? -4.82746  -22.78847 6.86673   1.000 16.73145 ? 55  PHE   A CD1 1 
ATOM   460  C CD2 . PHE   A 1 76  ? -4.45286  -24.63737 8.32172   1.000 13.93468 ? 55  PHE   A CD2 1 
ATOM   461  C CE1 . PHE   A 1 76  ? -6.18227  -22.84472 7.14006   1.000 13.05063 ? 55  PHE   A CE1 1 
ATOM   462  C CE2 . PHE   A 1 76  ? -5.80546  -24.69884 8.59934   1.000 19.92505 ? 55  PHE   A CE2 1 
ATOM   463  C CZ  . PHE   A 1 76  ? -6.67200  -23.80145 8.00664   1.000 17.67524 ? 55  PHE   A CZ  1 
ATOM   464  N N   . ALA   A 1 77  ? -0.20918  -20.99019 7.38304   1.000 15.12573 ? 56  ALA   A N   1 
ATOM   465  C CA  . ALA   A 1 77  ? 1.17863   -20.71551 7.74075   1.000 15.83203 ? 56  ALA   A CA  1 
ATOM   466  C C   . ALA   A 1 77  ? 1.63368   -21.53391 8.94316   1.000 20.13351 ? 56  ALA   A C   1 
ATOM   467  O O   . ALA   A 1 77  ? 2.80839   -21.91309 9.02227   1.000 20.95250 ? 56  ALA   A O   1 
ATOM   468  C CB  . ALA   A 1 77  ? 1.36653   -19.22326 8.01750   1.000 19.29158 ? 56  ALA   A CB  1 
ATOM   469  N N   . LEU   A 1 78  ? 0.73309   -21.80992 9.87716   1.000 14.40277 ? 57  LEU   A N   1 
ATOM   470  C CA  . LEU   A 1 78  ? 1.01407   -22.59316 11.06879  1.000 20.02514 ? 57  LEU   A CA  1 
ATOM   471  C C   . LEU   A 1 78  ? 0.69705   -24.06413 10.82279  1.000 22.37411 ? 57  LEU   A C   1 
ATOM   472  O O   . LEU   A 1 78  ? -0.10203  -24.39691 9.94167   1.000 21.60225 ? 57  LEU   A O   1 
ATOM   473  C CB  . LEU   A 1 78  ? 0.20772   -22.04488 12.24464  1.000 18.16164 ? 57  LEU   A CB  1 
ATOM   474  C CG  . LEU   A 1 78  ? 0.62204   -20.62010 12.61787  1.000 18.90049 ? 57  LEU   A CG  1 
ATOM   475  C CD1 . LEU   A 1 78  ? -0.03088  -20.17746 13.91338  1.000 20.04857 ? 57  LEU   A CD1 1 
ATOM   476  C CD2 . LEU   A 1 78  ? 2.13700   -20.50896 12.70575  1.000 23.47957 ? 57  LEU   A CD2 1 
ATOM   477  N N   . PRO   A 1 79  ? 1.31530   -24.97935 11.57356  1.000 24.94419 ? 58  PRO   A N   1 
ATOM   478  C CA  . PRO   A 1 79  ? 1.26334   -26.39350 11.18397  1.000 22.99037 ? 58  PRO   A CA  1 
ATOM   479  C C   . PRO   A 1 79  ? -0.10751  -27.01677 11.38526  1.000 26.46744 ? 58  PRO   A C   1 
ATOM   480  O O   . PRO   A 1 79  ? -0.89624  -26.60181 12.23800  1.000 23.89059 ? 58  PRO   A O   1 
ATOM   481  C CB  . PRO   A 1 79  ? 2.30703   -27.06225 12.08858  1.000 25.57298 ? 58  PRO   A CB  1 
ATOM   482  C CG  . PRO   A 1 79  ? 2.64822   -26.08096 13.14568  1.000 27.33471 ? 58  PRO   A CG  1 
ATOM   483  C CD  . PRO   A 1 79  ? 1.95869   -24.78636 12.88597  1.000 28.64495 ? 58  PRO   A CD  1 
ATOM   484  N N   . LEU   A 1 80  ? -0.37845  -28.03366 10.56729  1.000 31.60223 ? 59  LEU   A N   1 
ATOM   485  C CA  . LEU   A 1 80  ? -1.54367  -28.89266 10.71687  1.000 33.94299 ? 59  LEU   A CA  1 
ATOM   486  C C   . LEU   A 1 80  ? -1.19895  -30.24862 11.31716  1.000 34.49602 ? 59  LEU   A C   1 
ATOM   487  O O   . LEU   A 1 80  ? -2.10498  -30.96326 11.75870  1.000 42.99651 ? 59  LEU   A O   1 
ATOM   488  C CB  . LEU   A 1 80  ? -2.21852  -29.10186 9.35483   1.000 30.90333 ? 59  LEU   A CB  1 
ATOM   489  C CG  . LEU   A 1 80  ? -3.65984  -29.61135 9.30240   1.000 28.05626 ? 59  LEU   A CG  1 
ATOM   490  C CD1 . LEU   A 1 80  ? -4.63996  -28.51201 9.67745   1.000 25.78902 ? 59  LEU   A CD1 1 
ATOM   491  C CD2 . LEU   A 1 80  ? -3.96985  -30.16572 7.91891   1.000 30.23238 ? 59  LEU   A CD2 1 
ATOM   492  N N   . ASP   A 1 81  ? 0.08801   -30.60805 11.34457  1.000 41.94984 ? 60  ASP   A N   1 
ATOM   493  C CA  . ASP   A 1 81  ? 0.50163   -31.91322 11.85233  1.000 49.35039 ? 60  ASP   A CA  1 
ATOM   494  C C   . ASP   A 1 81  ? 0.18397   -32.06287 13.33492  1.000 45.26555 ? 60  ASP   A C   1 
ATOM   495  O O   . ASP   A 1 81  ? -0.19950  -33.14684 13.78945  1.000 45.84165 ? 60  ASP   A O   1 
ATOM   496  C CB  . ASP   A 1 81  ? 1.99852   -32.11473 11.60835  1.000 46.80127 ? 60  ASP   A CB  1 
ATOM   497  C CG  . ASP   A 1 81  ? 2.29659   -32.72548 10.25002  1.000 64.26684 ? 60  ASP   A CG  1 
ATOM   498  O OD1 . ASP   A 1 81  ? 1.43509   -32.63642 9.34889   1.000 55.03521 ? 60  ASP   A OD1 1 
ATOM   499  O OD2 . ASP   A 1 81  ? 3.40041   -33.28834 10.08178  1.000 65.03824 ? 60  ASP   A OD2 1 
ATOM   500  N N   . SER   A 1 82  ? 0.33869   -30.98459 14.10517  1.000 42.60631 ? 61  SER   A N   1 
ATOM   501  C CA  . SER   A 1 82  ? 0.18476   -31.01363 15.55470  1.000 48.15123 ? 61  SER   A CA  1 
ATOM   502  C C   . SER   A 1 82  ? -1.23359  -30.68257 16.00294  1.000 49.82989 ? 61  SER   A C   1 
ATOM   503  O O   . SER   A 1 82  ? -1.42210  -30.11976 17.09022  1.000 44.30776 ? 61  SER   A O   1 
ATOM   504  C CB  . SER   A 1 82  ? 1.18575   -30.05584 16.20222  1.000 49.57700 ? 61  SER   A CB  1 
ATOM   505  O OG  . SER   A 1 82  ? 1.11980   -28.77396 15.60034  1.000 50.34949 ? 61  SER   A OG  1 
ATOM   506  N N   . LEU   A 1 83  ? -2.23635  -31.00912 15.18543  1.000 50.20788 ? 62  LEU   A N   1 
ATOM   507  C CA  . LEU   A 1 83  ? -3.61609  -30.69549 15.53827  1.000 42.29123 ? 62  LEU   A CA  1 
ATOM   508  C C   . LEU   A 1 83  ? -4.04066  -31.43096 16.80534  1.000 44.09043 ? 62  LEU   A C   1 
ATOM   509  O O   . LEU   A 1 83  ? -4.72495  -30.86148 17.66458  1.000 33.04254 ? 62  LEU   A O   1 
ATOM   510  C CB  . LEU   A 1 83  ? -4.53521  -31.04337 14.36556  1.000 39.36367 ? 62  LEU   A CB  1 
ATOM   511  C CG  . LEU   A 1 83  ? -5.93405  -30.42626 14.27621  1.000 39.91705 ? 62  LEU   A CG  1 
ATOM   512  C CD1 . LEU   A 1 83  ? -6.45604  -30.55561 12.85235  1.000 37.31391 ? 62  LEU   A CD1 1 
ATOM   513  C CD2 . LEU   A 1 83  ? -6.90829  -31.05996 15.24979  1.000 36.30785 ? 62  LEU   A CD2 1 
ATOM   514  N N   . LEU   A 1 84  ? -3.64902  -32.70005 16.93773  1.000 45.78539 ? 63  LEU   A N   1 
ATOM   515  C CA  . LEU   A 1 84  ? -4.01076  -33.48184 18.11471  1.000 48.43738 ? 63  LEU   A CA  1 
ATOM   516  C C   . LEU   A 1 84  ? -3.12803  -33.18475 19.32017  1.000 49.76882 ? 63  LEU   A C   1 
ATOM   517  O O   . LEU   A 1 84  ? -3.54352  -33.45192 20.45273  1.000 49.20215 ? 63  LEU   A O   1 
ATOM   518  C CB  . LEU   A 1 84  ? -3.95455  -34.97786 17.79236  1.000 52.45156 ? 63  LEU   A CB  1 
ATOM   519  C CG  . LEU   A 1 84  ? -5.26646  -35.65381 17.38275  1.000 51.13334 ? 63  LEU   A CG  1 
ATOM   520  C CD1 . LEU   A 1 84  ? -5.89252  -34.97274 16.17334  1.000 43.02285 ? 63  LEU   A CD1 1 
ATOM   521  C CD2 . LEU   A 1 84  ? -5.03574  -37.12978 17.10375  1.000 54.37059 ? 63  LEU   A CD2 1 
ATOM   522  N N   . ASP   A 1 85  ? -1.92971  -32.64195 19.10925  1.000 47.73350 ? 64  ASP   A N   1 
ATOM   523  C CA  . ASP   A 1 85  ? -1.02263  -32.26509 20.19400  1.000 48.08099 ? 64  ASP   A CA  1 
ATOM   524  C C   . ASP   A 1 85  ? -0.60329  -30.81732 19.97860  1.000 46.13583 ? 64  ASP   A C   1 
ATOM   525  O O   . ASP   A 1 85  ? 0.50443   -30.54296 19.49581  1.000 46.34844 ? 64  ASP   A O   1 
ATOM   526  C CB  . ASP   A 1 85  ? 0.19119   -33.19392 20.25603  1.000 52.78082 ? 64  ASP   A CB  1 
ATOM   527  C CG  . ASP   A 1 85  ? 0.67399   -33.42973 21.67593  1.000 55.53328 ? 64  ASP   A CG  1 
ATOM   528  O OD1 . ASP   A 1 85  ? 0.48570   -32.53510 22.52699  1.000 56.79689 ? 64  ASP   A OD1 1 
ATOM   529  O OD2 . ASP   A 1 85  ? 1.24393   -34.50942 21.94064  1.000 55.89113 ? 64  ASP   A OD2 1 
ATOM   530  N N   . PRO   A 1 86  ? -1.46960  -29.86490 20.31483  1.000 42.16831 ? 65  PRO   A N   1 
ATOM   531  C CA  . PRO   A 1 86  ? -1.15242  -28.44952 20.07876  1.000 43.77664 ? 65  PRO   A CA  1 
ATOM   532  C C   . PRO   A 1 86  ? 0.03374   -28.00946 20.91559  1.000 42.96941 ? 65  PRO   A C   1 
ATOM   533  O O   . PRO   A 1 86  ? 0.17272   -28.41757 22.07859  1.000 41.09272 ? 65  PRO   A O   1 
ATOM   534  C CB  . PRO   A 1 86  ? -2.43029  -27.70502 20.50022  1.000 36.46922 ? 65  PRO   A CB  1 
ATOM   535  C CG  . PRO   A 1 86  ? -3.37219  -28.71180 21.02827  1.000 38.83784 ? 65  PRO   A CG  1 
ATOM   536  C CD  . PRO   A 1 86  ? -2.78391  -30.07460 20.94495  1.000 47.96412 ? 65  PRO   A CD  1 
ATOM   537  N N   . PRO   A 1 87  ? 0.90974   -27.17344 20.36284  1.000 36.67307 ? 66  PRO   A N   1 
ATOM   538  C CA  . PRO   A 1 87  ? 1.99784   -26.60858 21.17005  1.000 30.88869 ? 66  PRO   A CA  1 
ATOM   539  C C   . PRO   A 1 87  ? 1.48801   -25.55143 22.13644  1.000 33.12007 ? 66  PRO   A C   1 
ATOM   540  O O   . PRO   A 1 87  ? 0.28800   -25.26128 22.16668  1.000 34.10490 ? 66  PRO   A O   1 
ATOM   541  C CB  . PRO   A 1 87  ? 2.93473   -26.01307 20.11372  1.000 34.68300 ? 66  PRO   A CB  1 
ATOM   542  C CG  . PRO   A 1 87  ? 2.01724   -25.64655 18.99561  1.000 37.40239 ? 66  PRO   A CG  1 
ATOM   543  C CD  . PRO   A 1 87  ? 0.99836   -26.75634 18.95297  1.000 33.33539 ? 66  PRO   A CD  1 
ATOM   544  N N   . THR   A 1 88  ? 2.38291   -24.97199 22.93106  1.000 32.25108 ? 67  THR   A N   1 
ATOM   545  C CA  . THR   A 1 88  ? 1.97512   -23.94977 23.88144  1.000 31.63986 ? 67  THR   A CA  1 
ATOM   546  C C   . THR   A 1 88  ? 1.50138   -22.69654 23.14927  1.000 37.98000 ? 67  THR   A C   1 
ATOM   547  O O   . THR   A 1 88  ? 1.87900   -22.42818 22.00489  1.000 32.26438 ? 67  THR   A O   1 
ATOM   548  C CB  . THR   A 1 88  ? 3.12393   -23.59664 24.82791  1.000 37.59456 ? 67  THR   A CB  1 
ATOM   549  O OG1 . THR   A 1 88  ? 3.92659   -22.56310 24.24417  1.000 35.11655 ? 67  THR   A OG1 1 
ATOM   550  C CG2 . THR   A 1 88  ? 3.99357   -24.81878 25.08939  1.000 32.45325 ? 67  THR   A CG2 1 
ATOM   551  N N   . TRP   A 1 89  ? 0.64641   -21.92658 23.82638  1.000 34.65552 ? 68  TRP   A N   1 
ATOM   552  C CA  . TRP   A 1 89  ? 0.13639   -20.70066 23.22228  1.000 35.74566 ? 68  TRP   A CA  1 
ATOM   553  C C   . TRP   A 1 89  ? 1.23012   -19.65252 23.06318  1.000 36.28918 ? 68  TRP   A C   1 
ATOM   554  O O   . TRP   A 1 89  ? 1.14555   -18.80780 22.16556  1.000 37.28434 ? 68  TRP   A O   1 
ATOM   555  C CB  . TRP   A 1 89  ? -1.03058  -20.15391 24.04455  1.000 39.80543 ? 68  TRP   A CB  1 
ATOM   556  C CG  . TRP   A 1 89  ? -1.92941  -19.24611 23.26118  1.000 51.54213 ? 68  TRP   A CG  1 
ATOM   557  C CD1 . TRP   A 1 89  ? -2.52564  -19.52132 22.06351  1.000 47.67933 ? 68  TRP   A CD1 1 
ATOM   558  C CD2 . TRP   A 1 89  ? -2.37823  -17.93743 23.63897  1.000 48.69156 ? 68  TRP   A CD2 1 
ATOM   559  N NE1 . TRP   A 1 89  ? -3.29184  -18.45624 21.65880  1.000 45.60695 ? 68  TRP   A NE1 1 
ATOM   560  C CE2 . TRP   A 1 89  ? -3.22281  -17.47284 22.60955  1.000 52.19839 ? 68  TRP   A CE2 1 
ATOM   561  C CE3 . TRP   A 1 89  ? -2.14080  -17.10929 24.74048  1.000 52.29096 ? 68  TRP   A CE3 1 
ATOM   562  C CZ2 . TRP   A 1 89  ? -3.83022  -16.21808 22.64873  1.000 42.86205 ? 68  TRP   A CZ2 1 
ATOM   563  C CZ3 . TRP   A 1 89  ? -2.74796  -15.86416 24.77677  1.000 55.49288 ? 68  TRP   A CZ3 1 
ATOM   564  C CH2 . TRP   A 1 89  ? -3.57875  -15.43034 23.73714  1.000 47.27370 ? 68  TRP   A CH2 1 
ATOM   565  N N   . GLY   A 1 90  ? 2.25898   -19.69079 23.91173  1.000 29.47958 ? 69  GLY   A N   1 
ATOM   566  C CA  . GLY   A 1 90  ? 3.36747   -18.76373 23.75001  1.000 22.39661 ? 69  GLY   A CA  1 
ATOM   567  C C   . GLY   A 1 90  ? 4.11881   -18.97277 22.44849  1.000 30.03068 ? 69  GLY   A C   1 
ATOM   568  O O   . GLY   A 1 90  ? 4.41733   -18.01740 21.72692  1.000 24.03353 ? 69  GLY   A O   1 
ATOM   569  N N   . VAL   A 1 91  ? 4.43168   -20.23063 22.12528  1.000 29.62312 ? 70  VAL   A N   1 
ATOM   570  C CA  . VAL   A 1 91  ? 5.16250   -20.50641 20.89341  1.000 28.62590 ? 70  VAL   A CA  1 
ATOM   571  C C   . VAL   A 1 91  ? 4.27257   -20.36491 19.66415  1.000 25.85949 ? 70  VAL   A C   1 
ATOM   572  O O   . VAL   A 1 91  ? 4.78300   -20.13595 18.56170  1.000 25.04388 ? 70  VAL   A O   1 
ATOM   573  C CB  . VAL   A 1 91  ? 5.81638   -21.90213 20.94085  1.000 29.02454 ? 70  VAL   A CB  1 
ATOM   574  C CG1 . VAL   A 1 91  ? 6.45400   -22.14693 22.30089  1.000 27.41216 ? 70  VAL   A CG1 1 
ATOM   575  C CG2 . VAL   A 1 91  ? 4.80399   -22.98666 20.61562  1.000 32.60412 ? 70  VAL   A CG2 1 
ATOM   576  N N   . SER   A 1 92  ? 2.95108   -20.49318 19.81901  1.000 28.50488 ? 71  SER   A N   1 
ATOM   577  C CA  . SER   A 1 92  ? 2.05378   -20.25497 18.69205  1.000 23.69812 ? 71  SER   A CA  1 
ATOM   578  C C   . SER   A 1 92  ? 2.00424   -18.77560 18.33352  1.000 22.21698 ? 71  SER   A C   1 
ATOM   579  O O   . SER   A 1 92  ? 2.00631   -18.41578 17.15000  1.000 15.55309 ? 71  SER   A O   1 
ATOM   580  C CB  . SER   A 1 92  ? 0.65278   -20.77530 19.01118  1.000 18.57855 ? 71  SER   A CB  1 
ATOM   581  O OG  . SER   A 1 92  ? 0.56779   -22.17433 18.80459  1.000 23.43787 ? 71  SER   A OG  1 
ATOM   582  N N   . ILE   A 1 93  ? 1.95914   -17.90519 19.34347  1.000 21.29577 ? 72  ILE   A N   1 
ATOM   583  C CA  . ILE   A 1 93  ? 1.96454   -16.46770 19.09173  1.000 24.19022 ? 72  ILE   A CA  1 
ATOM   584  C C   . ILE   A 1 93  ? 3.27134   -16.04628 18.43295  1.000 17.64782 ? 72  ILE   A C   1 
ATOM   585  O O   . ILE   A 1 93  ? 3.27825   -15.24387 17.49092  1.000 16.22505 ? 72  ILE   A O   1 
ATOM   586  C CB  . ILE   A 1 93  ? 1.70927   -15.69960 20.40139  1.000 26.30767 ? 72  ILE   A CB  1 
ATOM   587  C CG1 . ILE   A 1 93  ? 0.31773   -16.03430 20.93946  1.000 28.11656 ? 72  ILE   A CG1 1 
ATOM   588  C CG2 . ILE   A 1 93  ? 1.86904   -14.20047 20.18933  1.000 24.56295 ? 72  ILE   A CG2 1 
ATOM   589  C CD1 . ILE   A 1 93  ? -0.80234  -15.30457 20.23190  1.000 24.68947 ? 72  ILE   A CD1 1 
ATOM   590  N N   . SER   A 1 94  ? 4.39715   -16.58107 18.91337  1.000 16.14969 ? 73  SER   A N   1 
ATOM   591  C CA  . SER   A 1 94  ? 5.68430   -16.24711 18.31286  1.000 19.26651 ? 73  SER   A CA  1 
ATOM   592  C C   . SER   A 1 94  ? 5.74881   -16.70973 16.86237  1.000 19.54285 ? 73  SER   A C   1 
ATOM   593  O O   . SER   A 1 94  ? 6.25875   -15.99000 15.99496  1.000 20.11940 ? 73  SER   A O   1 
ATOM   594  C CB  . SER   A 1 94  ? 6.82161   -16.86362 19.12743  1.000 22.60520 ? 73  SER   A CB  1 
ATOM   595  O OG  . SER   A 1 94  ? 7.96467   -17.08295 18.31926  1.000 32.06533 ? 73  SER   A OG  1 
ATOM   596  N N   . ARG   A 1 95  ? 5.23598   -17.91093 16.58067  1.000 17.77481 ? 74  ARG   A N   1 
ATOM   597  C CA  . ARG   A 1 95  ? 5.19093   -18.39398 15.20389  1.000 22.33734 ? 74  ARG   A CA  1 
ATOM   598  C C   . ARG   A 1 95  ? 4.28617   -17.52279 14.34127  1.000 17.79893 ? 74  ARG   A C   1 
ATOM   599  O O   . ARG   A 1 95  ? 4.63978   -17.17876 13.20667  1.000 17.27735 ? 74  ARG   A O   1 
ATOM   600  C CB  . ARG   A 1 95  ? 4.71293   -19.84494 15.16920  1.000 21.12751 ? 74  ARG   A CB  1 
ATOM   601  C CG  . ARG   A 1 95  ? 5.76301   -20.87560 15.53953  1.000 27.96188 ? 74  ARG   A CG  1 
ATOM   602  C CD  . ARG   A 1 95  ? 5.14667   -22.26620 15.57400  1.000 30.27539 ? 74  ARG   A CD  1 
ATOM   603  N NE  . ARG   A 1 95  ? 5.95021   -23.22130 16.32648  1.000 28.02601 ? 74  ARG   A NE  1 
ATOM   604  C CZ  . ARG   A 1 95  ? 5.58672   -24.47298 16.57051  1.000 31.19717 ? 74  ARG   A CZ  1 
ATOM   605  N NH1 . ARG   A 1 95  ? 4.44019   -24.95942 16.12347  1.000 32.79410 ? 74  ARG   A NH1 1 
ATOM   606  N NH2 . ARG   A 1 95  ? 6.39391   -25.25692 17.27932  1.000 35.56643 ? 74  ARG   A NH2 1 
ATOM   607  N N   . GLY   A 1 96  ? 3.10933   -17.16259 14.85776  1.000 13.58375 ? 75  GLY   A N   1 
ATOM   608  C CA  . GLY   A 1 96  ? 2.22521   -16.28925 14.10349  1.000 16.84497 ? 75  GLY   A CA  1 
ATOM   609  C C   . GLY   A 1 96  ? 2.84062   -14.92696 13.85510  1.000 15.67275 ? 75  GLY   A C   1 
ATOM   610  O O   . GLY   A 1 96  ? 2.70229   -14.35911 12.76850  1.000 11.39291 ? 75  GLY   A O   1 
ATOM   611  N N   . LEU   A 1 97  ? 3.53454   -14.38927 14.86016  1.000 13.22825 ? 76  LEU   A N   1 
ATOM   612  C CA  . LEU   A 1 97  ? 4.25720   -13.13302 14.69439  1.000 12.93617 ? 76  LEU   A CA  1 
ATOM   613  C C   . LEU   A 1 97  ? 5.33354   -13.25919 13.62299  1.000 13.69598 ? 76  LEU   A C   1 
ATOM   614  O O   . LEU   A 1 97  ? 5.45484   -12.40159 12.73990  1.000 10.73696 ? 76  LEU   A O   1 
ATOM   615  C CB  . LEU   A 1 97  ? 4.87099   -12.72378 16.03585  1.000 18.04529 ? 76  LEU   A CB  1 
ATOM   616  C CG  . LEU   A 1 97  ? 5.51926   -11.35458 16.24721  1.000 23.55618 ? 76  LEU   A CG  1 
ATOM   617  C CD1 . LEU   A 1 97  ? 4.85886   -10.28400 15.40643  1.000 17.27756 ? 76  LEU   A CD1 1 
ATOM   618  C CD2 . LEU   A 1 97  ? 5.46693   -10.98570 17.72553  1.000 20.21765 ? 76  LEU   A CD2 1 
ATOM   619  N N   . GLU   A 1 98  ? 6.11915   -14.33645 13.67818  1.000 13.85007 ? 77  GLU   A N   1 
ATOM   620  C CA  . GLU   A 1 98  ? 7.20932   -14.50129 12.72330  1.000 14.31876 ? 77  GLU   A CA  1 
ATOM   621  C C   . GLU   A 1 98  ? 6.67725   -14.73715 11.31441  1.000 11.35596 ? 77  GLU   A C   1 
ATOM   622  O O   . GLU   A 1 98  ? 7.20437   -14.17822 10.34553  1.000 12.91799 ? 77  GLU   A O   1 
ATOM   623  C CB  . GLU   A 1 98  ? 8.11893   -15.65058 13.15994  1.000 14.83265 ? 77  GLU   A CB  1 
ATOM   624  C CG  . GLU   A 1 98  ? 9.37638   -15.81091 12.31660  1.000 26.01256 ? 77  GLU   A CG  1 
ATOM   625  C CD  . GLU   A 1 98  ? 10.23814  -14.55850 12.30468  1.000 27.20527 ? 77  GLU   A CD  1 
ATOM   626  O OE1 . GLU   A 1 98  ? 10.31600  -13.87454 13.34801  1.000 25.53271 ? 77  GLU   A OE1 1 
ATOM   627  O OE2 . GLU   A 1 98  ? 10.84131  -14.25903 11.25418  1.000 29.43366 ? 77  GLU   A OE2 1 
ATOM   628  N N   . ASN   A 1 99  ? 5.62704   -15.55375 11.18011  1.000 12.02681 ? 78  ASN   A N   1 
ATOM   629  C CA  . ASN   A 1 99  ? 5.03457   -15.78279 9.86446   1.000 11.93216 ? 78  ASN   A CA  1 
ATOM   630  C C   . ASN   A 1 99  ? 4.40953   -14.50843 9.30957   1.000 13.80306 ? 78  ASN   A C   1 
ATOM   631  O O   . ASN   A 1 99  ? 4.50902   -14.23637 8.10746   1.000 10.00029 ? 78  ASN   A O   1 
ATOM   632  C CB  . ASN   A 1 99  ? 4.00265   -16.90612 9.93987   1.000 17.54380 ? 78  ASN   A CB  1 
ATOM   633  C CG  . ASN   A 1 99  ? 4.64086   -18.28417 9.90309   1.000 16.42327 ? 78  ASN   A CG  1 
ATOM   634  O OD1 . ASN   A 1 99  ? 4.98408   -18.79374 8.83639   1.000 29.66347 ? 78  ASN   A OD1 1 
ATOM   635  N ND2 . ASN   A 1 99  ? 4.80375   -18.89260 11.07241  1.000 18.43710 ? 78  ASN   A ND2 1 
ATOM   636  N N   . SER   A 1 100 ? 3.76197   -13.71526 10.16864  1.000 10.43541 ? 79  SER   A N   1 
ATOM   637  C CA  . SER   A 1 100 ? 3.21490   -12.43662 9.72400   1.000 8.37812  ? 79  SER   A CA  1 
ATOM   638  C C   . SER   A 1 100 ? 4.31436   -11.52886 9.19134   1.000 9.45101  ? 79  SER   A C   1 
ATOM   639  O O   . SER   A 1 100 ? 4.15962   -10.90862 8.13215   1.000 7.75017  ? 79  SER   A O   1 
ATOM   640  C CB  . SER   A 1 100 ? 2.47311   -11.75029 10.87317  1.000 8.83975  ? 79  SER   A CB  1 
ATOM   641  O OG  . SER   A 1 100 ? 1.31727   -12.47805 11.25302  1.000 13.25837 ? 79  SER   A OG  1 
ATOM   642  N N   . LEU   A 1 101 ? 5.43857   -11.45091 9.90893   1.000 9.45541  ? 80  LEU   A N   1 
ATOM   643  C CA  . LEU   A 1 101 ? 6.55870   -10.63230 9.45749   1.000 11.89292 ? 80  LEU   A CA  1 
ATOM   644  C C   . LEU   A 1 101 ? 7.11239   -11.12946 8.12941   1.000 9.85977  ? 80  LEU   A C   1 
ATOM   645  O O   . LEU   A 1 101 ? 7.43172   -10.32729 7.24531   1.000 10.99520 ? 80  LEU   A O   1 
ATOM   646  C CB  . LEU   A 1 101 ? 7.65898   -10.61753 10.51895  1.000 15.13356 ? 80  LEU   A CB  1 
ATOM   647  C CG  . LEU   A 1 101 ? 7.35698   -9.84315  11.80142  1.000 16.68006 ? 80  LEU   A CG  1 
ATOM   648  C CD1 . LEU   A 1 101 ? 8.47678   -10.02797 12.81443  1.000 17.53451 ? 80  LEU   A CD1 1 
ATOM   649  C CD2 . LEU   A 1 101 ? 7.16156   -8.37171  11.47974  1.000 20.08800 ? 80  LEU   A CD2 1 
ATOM   650  N N   . ASN   A 1 102 ? 7.24671   -12.44956 7.97521   1.000 10.12308 ? 81  ASN   A N   1 
ATOM   651  C CA  . ASN   A 1 102 ? 7.81055   -12.99518 6.74300   1.000 11.25027 ? 81  ASN   A CA  1 
ATOM   652  C C   . ASN   A 1 102 ? 6.92598   -12.68937 5.54257   1.000 11.18154 ? 81  ASN   A C   1 
ATOM   653  O O   . ASN   A 1 102 ? 7.42128   -12.30074 4.47702   1.000 10.55854 ? 81  ASN   A O   1 
ATOM   654  C CB  . ASN   A 1 102 ? 8.00932   -14.50304 6.87477   1.000 10.76206 ? 81  ASN   A CB  1 
ATOM   655  C CG  . ASN   A 1 102 ? 9.14437   -14.85986 7.80573   1.000 16.88377 ? 81  ASN   A CG  1 
ATOM   656  O OD1 . ASN   A 1 102 ? 10.01357  -14.03513 8.09039   1.000 15.02175 ? 81  ASN   A OD1 1 
ATOM   657  N ND2 . ASN   A 1 102 ? 9.15055   -16.10034 8.27717   1.000 17.73969 ? 81  ASN   A ND2 1 
ATOM   658  N N   . LEU   A 1 103 ? 5.61299   -12.87311 5.69165   1.000 12.03532 ? 82  LEU   A N   1 
ATOM   659  C CA  . LEU   A 1 103 ? 4.70486   -12.62896 4.57767   1.000 10.85999 ? 82  LEU   A CA  1 
ATOM   660  C C   . LEU   A 1 103 ? 4.66150   -11.15222 4.21076   1.000 10.46919 ? 82  LEU   A C   1 
ATOM   661  O O   . LEU   A 1 103 ? 4.64457   -10.80331 3.02538   1.000 8.94603  ? 82  LEU   A O   1 
ATOM   662  C CB  . LEU   A 1 103 ? 3.31049   -13.14814 4.91837   1.000 9.78537  ? 82  LEU   A CB  1 
ATOM   663  C CG  . LEU   A 1 103 ? 3.26793   -14.65774 5.15339   1.000 11.64256 ? 82  LEU   A CG  1 
ATOM   664  C CD1 . LEU   A 1 103 ? 2.00201   -15.07380 5.88535   1.000 17.00783 ? 82  LEU   A CD1 1 
ATOM   665  C CD2 . LEU   A 1 103 ? 3.39447   -15.38157 3.82420   1.000 14.34252 ? 82  LEU   A CD2 1 
ATOM   666  N N   . ALA   A 1 104 ? 4.64488   -10.27065 5.21151   1.000 8.97338  ? 83  ALA   A N   1 
ATOM   667  C CA  . ALA   A 1 104 ? 4.64317   -8.83950  4.92897   1.000 11.34760 ? 83  ALA   A CA  1 
ATOM   668  C C   . ALA   A 1 104 ? 5.93726   -8.40822  4.25103   1.000 9.22710  ? 83  ALA   A C   1 
ATOM   669  O O   . ALA   A 1 104 ? 5.91402   -7.59368  3.32287   1.000 6.45203  ? 83  ALA   A O   1 
ATOM   670  C CB  . ALA   A 1 104 ? 4.42084   -8.04858  6.21742   1.000 7.40908  ? 83  ALA   A CB  1 
ATOM   671  N N   . GLU   A 1 105 ? 7.07753   -8.93774  4.70463   1.000 11.92035 ? 84  GLU   A N   1 
ATOM   672  C CA  . GLU   A 1 105 ? 8.34891   -8.57459  4.08736   1.000 8.50427  ? 84  GLU   A CA  1 
ATOM   673  C C   . GLU   A 1 105 ? 8.39045   -8.99992  2.62638   1.000 9.49612  ? 84  GLU   A C   1 
ATOM   674  O O   . GLU   A 1 105 ? 8.84053   -8.23778  1.76322   1.000 12.76020 ? 84  GLU   A O   1 
ATOM   675  C CB  . GLU   A 1 105 ? 9.50996   -9.19579  4.86428   1.000 11.58621 ? 84  GLU   A CB  1 
ATOM   676  C CG  . GLU   A 1 105 ? 10.87604  -8.92092  4.25439   1.000 12.92864 ? 84  GLU   A CG  1 
ATOM   677  C CD  . GLU   A 1 105 ? 11.97451  -9.74028  4.90244   1.000 16.28977 ? 84  GLU   A CD  1 
ATOM   678  O OE1 . GLU   A 1 105 ? 11.66396  -10.53945 5.81040   1.000 18.04974 ? 84  GLU   A OE1 1 
ATOM   679  O OE2 . GLU   A 1 105 ? 13.14633  -9.58923  4.49887   1.000 17.61407 ? 84  GLU   A OE2 1 
ATOM   680  N N   . THR   A 1 106 ? 7.90883   -10.20855 2.32917   1.000 10.37190 ? 85  THR   A N   1 
ATOM   681  C CA  . THR   A 1 106 ? 7.89551   -10.69051 0.95151   1.000 12.80283 ? 85  THR   A CA  1 
ATOM   682  C C   . THR   A 1 106 ? 7.00605   -9.81882  0.07060   1.000 10.38842 ? 85  THR   A C   1 
ATOM   683  O O   . THR   A 1 106 ? 7.41575   -9.39076  -1.01557  1.000 10.76503 ? 85  THR   A O   1 
ATOM   684  C CB  . THR   A 1 106 ? 7.43101   -12.14850 0.92283   1.000 10.28927 ? 85  THR   A CB  1 
ATOM   685  O OG1 . THR   A 1 106 ? 8.39451   -12.96824 1.59677   1.000 12.72778 ? 85  THR   A OG1 1 
ATOM   686  C CG2 . THR   A 1 106 ? 7.26298   -12.63997 -0.50645  1.000 12.77401 ? 85  THR   A CG2 1 
ATOM   687  N N   . ALA   A 1 107 ? 5.78897   -9.52443  0.53880   1.000 10.52659 ? 86  ALA   A N   1 
ATOM   688  C CA  . ALA   A 1 107 ? 4.85179   -8.73761  -0.25747  1.000 9.21947  ? 86  ALA   A CA  1 
ATOM   689  C C   . ALA   A 1 107 ? 5.38043   -7.33332  -0.51886  1.000 7.63327  ? 86  ALA   A C   1 
ATOM   690  O O   . ALA   A 1 107 ? 5.29364   -6.82897  -1.64545  1.000 10.15199 ? 86  ALA   A O   1 
ATOM   691  C CB  . ALA   A 1 107 ? 3.49467   -8.67392  0.44404   1.000 6.83028  ? 86  ALA   A CB  1 
ATOM   692  N N   . ILE   A 1 108 ? 5.92704   -6.68512  0.51105   1.000 6.90365  ? 87  ILE   A N   1 
ATOM   693  C CA  . ILE   A 1 108 ? 6.46166   -5.33583  0.34677   1.000 9.91141  ? 87  ILE   A CA  1 
ATOM   694  C C   . ILE   A 1 108 ? 7.64899   -5.34604  -0.60651  1.000 8.16483  ? 87  ILE   A C   1 
ATOM   695  O O   . ILE   A 1 108 ? 7.77578   -4.47024  -1.47102  1.000 6.83191  ? 87  ILE   A O   1 
ATOM   696  C CB  . ILE   A 1 108 ? 6.84018   -4.73752  1.71559   1.000 9.62250  ? 87  ILE   A CB  1 
ATOM   697  C CG1 . ILE   A 1 108 ? 5.58892   -4.50528  2.56816   1.000 10.92697 ? 87  ILE   A CG1 1 
ATOM   698  C CG2 . ILE   A 1 108 ? 7.61538   -3.43796  1.54208   1.000 6.18710  ? 87  ILE   A CG2 1 
ATOM   699  C CD1 . ILE   A 1 108 ? 5.88637   -4.31148  4.04079   1.000 13.15564 ? 87  ILE   A CD1 1 
ATOM   700  N N   . THR   A 1 109 ? 8.53921   -6.33289  -0.46175  1.000 9.71521  ? 88  THR   A N   1 
ATOM   701  C CA  . THR   A 1 109 ? 9.70499   -6.41393  -1.33885  1.000 9.37178  ? 88  THR   A CA  1 
ATOM   702  C C   . THR   A 1 109 ? 9.29251   -6.59650  -2.79469  1.000 11.49842 ? 88  THR   A C   1 
ATOM   703  O O   . THR   A 1 109 ? 9.83287   -5.93170  -3.68609  1.000 11.57325 ? 88  THR   A O   1 
ATOM   704  C CB  . THR   A 1 109 ? 10.62463  -7.55206  -0.89364  1.000 15.48169 ? 88  THR   A CB  1 
ATOM   705  O OG1 . THR   A 1 109 ? 11.18742  -7.24086  0.38620   1.000 18.29317 ? 88  THR   A OG1 1 
ATOM   706  C CG2 . THR   A 1 109 ? 11.74859  -7.76076  -1.90264  1.000 15.62254 ? 88  THR   A CG2 1 
ATOM   707  N N   . LYS   A 1 110 ? 8.32716   -7.48400  -3.05533  1.000 14.38078 ? 89  LYS   A N   1 
ATOM   708  C CA  . LYS   A 1 110 ? 7.82430   -7.64683  -4.41774  1.000 11.17569 ? 89  LYS   A CA  1 
ATOM   709  C C   . LYS   A 1 110 ? 7.22117   -6.34923  -4.93644  1.000 10.77175 ? 89  LYS   A C   1 
ATOM   710  O O   . LYS   A 1 110 ? 7.41189   -5.98755  -6.10420  1.000 9.18768  ? 89  LYS   A O   1 
ATOM   711  C CB  . LYS   A 1 110 ? 6.78233   -8.76394  -4.47042  1.000 11.75559 ? 89  LYS   A CB  1 
ATOM   712  C CG  . LYS   A 1 110 ? 7.30087   -10.14886 -4.12719  1.000 18.25252 ? 89  LYS   A CG  1 
ATOM   713  C CD  . LYS   A 1 110 ? 6.14724   -11.05034 -3.70781  1.000 16.13673 ? 89  LYS   A CD  1 
ATOM   714  C CE  . LYS   A 1 110 ? 5.35278   -11.54864 -4.89933  1.000 22.32397 ? 89  LYS   A CE  1 
ATOM   715  N NZ  . LYS   A 1 110 ? 4.56616   -12.76352 -4.54389  1.000 19.15854 ? 89  LYS   A NZ  1 
ATOM   716  N N   . LEU   A 1 111 ? 6.47916   -5.64452  -4.07954  1.000 10.05735 ? 90  LEU   A N   1 
ATOM   717  C CA  . LEU   A 1 111 ? 5.86725   -4.37760  -4.46394  1.000 6.51497  ? 90  LEU   A CA  1 
ATOM   718  C C   . LEU   A 1 111 ? 6.92372   -3.33944  -4.82061  1.000 10.58310 ? 90  LEU   A C   1 
ATOM   719  O O   . LEU   A 1 111 ? 6.81019   -2.64353  -5.83614  1.000 10.09678 ? 90  LEU   A O   1 
ATOM   720  C CB  . LEU   A 1 111 ? 4.98601   -3.86714  -3.32296  1.000 7.61520  ? 90  LEU   A CB  1 
ATOM   721  C CG  . LEU   A 1 111 ? 4.04890   -2.69615  -3.61774  1.000 10.62468 ? 90  LEU   A CG  1 
ATOM   722  C CD1 . LEU   A 1 111 ? 3.06902   -3.05651  -4.72737  1.000 11.95205 ? 90  LEU   A CD1 1 
ATOM   723  C CD2 . LEU   A 1 111 ? 3.32685   -2.24298  -2.35158  1.000 9.30933  ? 90  LEU   A CD2 1 
ATOM   724  N N   . LEU   A 1 112 ? 7.95168   -3.20746  -3.97832  1.000 7.68185  ? 91  LEU   A N   1 
ATOM   725  C CA  . LEU   A 1 112 ? 9.01122   -2.23998  -4.24199  1.000 10.62667 ? 91  LEU   A CA  1 
ATOM   726  C C   . LEU   A 1 112 ? 9.79729   -2.60736  -5.49440  1.000 10.85890 ? 91  LEU   A C   1 
ATOM   727  O O   . LEU   A 1 112 ? 10.17000  -1.72881  -6.28002  1.000 12.20056 ? 91  LEU   A O   1 
ATOM   728  C CB  . LEU   A 1 112 ? 9.94460   -2.14131  -3.03272  1.000 9.56542  ? 91  LEU   A CB  1 
ATOM   729  C CG  . LEU   A 1 112 ? 9.34904   -1.56019  -1.74688  1.000 14.77541 ? 91  LEU   A CG  1 
ATOM   730  C CD1 . LEU   A 1 112 ? 10.30051  -1.73070  -0.57125  1.000 11.98272 ? 91  LEU   A CD1 1 
ATOM   731  C CD2 . LEU   A 1 112 ? 8.99736   -0.09534  -1.94609  1.000 9.61338  ? 91  LEU   A CD2 1 
ATOM   732  N N   . GLU   A 1 113 ? 10.06532  -3.89901  -5.69436  1.000 12.01979 ? 92  GLU   A N   1 
ATOM   733  C CA  . GLU   A 1 113 ? 10.86133  -4.31220  -6.84575  1.000 14.12837 ? 92  GLU   A CA  1 
ATOM   734  C C   . GLU   A 1 113 ? 10.09495  -4.12639  -8.15084  1.000 16.60581 ? 92  GLU   A C   1 
ATOM   735  O O   . GLU   A 1 113 ? 10.66205  -3.66437  -9.14802  1.000 15.56862 ? 92  GLU   A O   1 
ATOM   736  C CB  . GLU   A 1 113 ? 11.30472  -5.76531  -6.68237  1.000 17.37968 ? 92  GLU   A CB  1 
ATOM   737  C CG  . GLU   A 1 113 ? 12.64084  -5.92292  -5.97359  1.000 24.21454 ? 92  GLU   A CG  1 
ATOM   738  C CD  . GLU   A 1 113 ? 12.97642  -7.37077  -5.67670  1.000 33.27016 ? 92  GLU   A CD  1 
ATOM   739  O OE1 . GLU   A 1 113 ? 12.24219  -8.26138  -6.15492  1.000 35.19177 ? 92  GLU   A OE1 1 
ATOM   740  O OE2 . GLU   A 1 113 ? 13.96795  -7.61887  -4.95671  1.000 31.57039 ? 92  GLU   A OE2 1 
ATOM   741  N N   . LYS   A 1 114 ? 8.80473   -4.47153  -8.16810  1.000 11.56374 ? 93  LYS   A N   1 
ATOM   742  C CA  . LYS   A 1 114 ? 8.04386   -4.37257  -9.40872  1.000 14.74379 ? 93  LYS   A CA  1 
ATOM   743  C C   . LYS   A 1 114 ? 7.77090   -2.92782  -9.80639  1.000 17.98844 ? 93  LYS   A C   1 
ATOM   744  O O   . LYS   A 1 114 ? 7.53725   -2.65858  -10.98996 1.000 17.72306 ? 93  LYS   A O   1 
ATOM   745  C CB  . LYS   A 1 114 ? 6.73048   -5.15013  -9.29307  1.000 14.04494 ? 93  LYS   A CB  1 
ATOM   746  C CG  . LYS   A 1 114 ? 5.67293   -4.49785  -8.42492  1.000 17.52738 ? 93  LYS   A CG  1 
ATOM   747  C CD  . LYS   A 1 114 ? 4.57740   -5.49006  -8.06684  1.000 16.40016 ? 93  LYS   A CD  1 
ATOM   748  C CE  . LYS   A 1 114 ? 3.76904   -5.89334  -9.28730  1.000 11.37331 ? 93  LYS   A CE  1 
ATOM   749  N NZ  . LYS   A 1 114 ? 2.66838   -6.83758  -8.93264  1.000 9.49169  ? 93  LYS   A NZ  1 
ATOM   750  N N   . THR   A 1 115 ? 7.80016   -1.99586  -8.85229  1.000 15.95721 ? 94  THR   A N   1 
ATOM   751  C CA  . THR   A 1 115 ? 7.62197   -0.57844  -9.13760  1.000 16.01399 ? 94  THR   A CA  1 
ATOM   752  C C   . THR   A 1 115 ? 8.93335   0.19235   -9.21248  1.000 16.14682 ? 94  THR   A C   1 
ATOM   753  O O   . THR   A 1 115 ? 8.91151   1.37665   -9.56693  1.000 15.71045 ? 94  THR   A O   1 
ATOM   754  C CB  . THR   A 1 115 ? 6.72448   0.06918   -8.07830  1.000 14.94353 ? 94  THR   A CB  1 
ATOM   755  O OG1 . THR   A 1 115 ? 7.37852   0.02012   -6.80369  1.000 15.46120 ? 94  THR   A OG1 1 
ATOM   756  C CG2 . THR   A 1 115 ? 5.40644   -0.66056  -7.99366  1.000 12.69620 ? 94  THR   A CG2 1 
ATOM   757  N N   . ASN   A 1 116 ? 10.06340  -0.44926  -8.90159  1.000 19.01717 ? 95  ASN   A N   1 
ATOM   758  C CA  . ASN   A 1 116 ? 11.37885  0.19641   -8.90401  1.000 13.38182 ? 95  ASN   A CA  1 
ATOM   759  C C   . ASN   A 1 116 ? 11.39807  1.41041   -7.97437  1.000 19.98172 ? 95  ASN   A C   1 
ATOM   760  O O   . ASN   A 1 116 ? 11.83101  2.50402   -8.34413  1.000 18.20489 ? 95  ASN   A O   1 
ATOM   761  C CB  . ASN   A 1 116 ? 11.80334  0.57981   -10.32516 1.000 22.23466 ? 95  ASN   A CB  1 
ATOM   762  C CG  . ASN   A 1 116 ? 13.29574  0.83300   -10.44078 1.000 31.33956 ? 95  ASN   A CG  1 
ATOM   763  O OD1 . ASN   A 1 116 ? 14.10668  0.10148   -9.87274  1.000 35.05351 ? 95  ASN   A OD1 1 
ATOM   764  N ND2 . ASN   A 1 116 ? 13.66551  1.86495   -11.19160 1.000 25.03807 ? 95  ASN   A ND2 1 
ATOM   765  N N   . VAL   A 1 117 ? 10.92239  1.20534   -6.74877  1.000 16.75544 ? 96  VAL   A N   1 
ATOM   766  C CA  . VAL   A 1 117 ? 10.84872  2.25135   -5.73741  1.000 11.46929 ? 96  VAL   A CA  1 
ATOM   767  C C   . VAL   A 1 117 ? 11.72578  1.84080   -4.56291  1.000 11.14550 ? 96  VAL   A C   1 
ATOM   768  O O   . VAL   A 1 117 ? 11.63693  0.70475   -4.08224  1.000 11.55330 ? 96  VAL   A O   1 
ATOM   769  C CB  . VAL   A 1 117 ? 9.39744   2.49581   -5.28553  1.000 17.10557 ? 96  VAL   A CB  1 
ATOM   770  C CG1 . VAL   A 1 117 ? 9.35873   3.40328   -4.06608  1.000 12.98363 ? 96  VAL   A CG1 1 
ATOM   771  C CG2 . VAL   A 1 117 ? 8.58082   3.08475   -6.43014  1.000 13.26710 ? 96  VAL   A CG2 1 
ATOM   772  N N   . GLN   A 1 118 ? 12.58236  2.75504   -4.11822  1.000 13.29945 ? 97  GLN   A N   1 
ATOM   773  C CA  . GLN   A 1 118 ? 13.43979  2.47491   -2.97992  1.000 12.53188 ? 97  GLN   A CA  1 
ATOM   774  C C   . GLN   A 1 118 ? 12.66708  2.62726   -1.67061  1.000 11.35657 ? 97  GLN   A C   1 
ATOM   775  O O   . GLN   A 1 118 ? 11.77362  3.47061   -1.56470  1.000 11.45734 ? 97  GLN   A O   1 
ATOM   776  C CB  . GLN   A 1 118 ? 14.64496  3.40938   -2.97560  1.000 11.69406 ? 97  GLN   A CB  1 
ATOM   777  C CG  . GLN   A 1 118 ? 15.57300  3.22110   -4.16498  1.000 16.05427 ? 97  GLN   A CG  1 
ATOM   778  C CD  . GLN   A 1 118 ? 16.18955  1.83966   -4.20240  1.000 17.17651 ? 97  GLN   A CD  1 
ATOM   779  O OE1 . GLN   A 1 118 ? 16.85016  1.41951   -3.25541  1.000 22.01926 ? 97  GLN   A OE1 1 
ATOM   780  N NE2 . GLN   A 1 118 ? 15.96934  1.11995   -5.29914  1.000 22.81444 ? 97  GLN   A NE2 1 
ATOM   781  N N   . PRO   A 1 119 ? 12.99994  1.81922   -0.65802  1.000 11.41691 ? 98  PRO   A N   1 
ATOM   782  C CA  . PRO   A 1 119 ? 12.32758  1.96785   0.64533   1.000 14.37321 ? 98  PRO   A CA  1 
ATOM   783  C C   . PRO   A 1 119 ? 12.45440  3.36126   1.23762   1.000 17.74865 ? 98  PRO   A C   1 
ATOM   784  O O   . PRO   A 1 119 ? 11.49988  3.86105   1.84817   1.000 13.11967 ? 98  PRO   A O   1 
ATOM   785  C CB  . PRO   A 1 119 ? 13.02905  0.91489   1.51491   1.000 16.76814 ? 98  PRO   A CB  1 
ATOM   786  C CG  . PRO   A 1 119 ? 13.49123  -0.12180  0.54793   1.000 15.53399 ? 98  PRO   A CG  1 
ATOM   787  C CD  . PRO   A 1 119 ? 13.83006  0.60404   -0.72505  1.000 12.95053 ? 98  PRO   A CD  1 
ATOM   788  N N   . GLN   A 1 120 ? 13.60706  4.01267   1.05808   1.000 16.62538 ? 99  GLN   A N   1 
ATOM   789  C CA  . GLN   A 1 120 ? 13.82472  5.33657   1.63034   1.000 17.18115 ? 99  GLN   A CA  1 
ATOM   790  C C   . GLN   A 1 120 ? 12.90689  6.39306   1.02883   1.000 16.75850 ? 99  GLN   A C   1 
ATOM   791  O O   . GLN   A 1 120 ? 12.78239  7.48242   1.59934   1.000 16.92429 ? 99  GLN   A O   1 
ATOM   792  C CB  . GLN   A 1 120 ? 15.28269  5.75593   1.43986   1.000 18.66486 ? 99  GLN   A CB  1 
ATOM   793  C CG  . GLN   A 1 120 ? 15.68661  5.89428   -0.02114  1.000 20.31557 ? 99  GLN   A CG  1 
ATOM   794  C CD  . GLN   A 1 120 ? 17.05793  6.52096   -0.19558  1.000 34.45801 ? 99  GLN   A CD  1 
ATOM   795  O OE1 . GLN   A 1 120 ? 17.17556  7.71668   -0.46586  1.000 29.63215 ? 99  GLN   A OE1 1 
ATOM   796  N NE2 . GLN   A 1 120 ? 18.10244  5.71333   -0.04959  1.000 31.86650 ? 99  GLN   A NE2 1 
ATOM   797  N N   . ASP   A 1 121 ? 12.26641  6.10335   -0.10364  1.000 15.51002 ? 100 ASP   A N   1 
ATOM   798  C CA  . ASP   A 1 121 ? 11.36849  7.04504   -0.75715  1.000 12.99079 ? 100 ASP   A CA  1 
ATOM   799  C C   . ASP   A 1 121 ? 9.90594   6.80861   -0.40444  1.000 13.33550 ? 100 ASP   A C   1 
ATOM   800  O O   . ASP   A 1 121 ? 9.02433   7.41398   -1.02171  1.000 12.59868 ? 100 ASP   A O   1 
ATOM   801  C CB  . ASP   A 1 121 ? 11.55623  6.99241   -2.27319  1.000 16.70116 ? 100 ASP   A CB  1 
ATOM   802  C CG  . ASP   A 1 121 ? 12.93245  7.45589   -2.70062  1.000 21.95007 ? 100 ASP   A CG  1 
ATOM   803  O OD1 . ASP   A 1 121 ? 13.50394  8.32973   -2.01333  1.000 18.16925 ? 100 ASP   A OD1 1 
ATOM   804  O OD2 . ASP   A 1 121 ? 13.44098  6.94687   -3.72002  1.000 19.92923 ? 100 ASP   A OD2 1 
ATOM   805  N N   . ILE   A 1 122 ? 9.62955   5.94198   0.56315   1.000 12.27482 ? 101 ILE   A N   1 
ATOM   806  C CA  . ILE   A 1 122 ? 8.28330   5.73277   1.07999   1.000 10.44819 ? 101 ILE   A CA  1 
ATOM   807  C C   . ILE   A 1 122 ? 8.13000   6.57255   2.34026   1.000 12.55914 ? 101 ILE   A C   1 
ATOM   808  O O   . ILE   A 1 122 ? 8.96318   6.49283   3.25170   1.000 10.30370 ? 101 ILE   A O   1 
ATOM   809  C CB  . ILE   A 1 122 ? 8.02283   4.24596   1.37441   1.000 10.51782 ? 101 ILE   A CB  1 
ATOM   810  C CG1 . ILE   A 1 122 ? 8.22269   3.39515   0.11448   1.000 11.88228 ? 101 ILE   A CG1 1 
ATOM   811  C CG2 . ILE   A 1 122 ? 6.62351   4.05845   1.95874   1.000 8.08200  ? 101 ILE   A CG2 1 
ATOM   812  C CD1 . ILE   A 1 122 ? 7.27485   3.71857   -1.02787  1.000 9.67770  ? 101 ILE   A CD1 1 
ATOM   813  N N   . SER   A 1 123 ? 7.07585   7.38647   2.39166   1.000 8.99022  ? 102 SER   A N   1 
ATOM   814  C CA  . SER   A 1 123 ? 6.85644   8.26788   3.53220   1.000 8.68768  ? 102 SER   A CA  1 
ATOM   815  C C   . SER   A 1 123 ? 6.02039   7.62469   4.62787   1.000 7.52194  ? 102 SER   A C   1 
ATOM   816  O O   . SER   A 1 123 ? 6.21372   7.94170   5.80757   1.000 8.45804  ? 102 SER   A O   1 
ATOM   817  C CB  . SER   A 1 123 ? 6.17641   9.56441   3.07955   1.000 10.52830 ? 102 SER   A CB  1 
ATOM   818  O OG  . SER   A 1 123 ? 6.94553   10.24113  2.10059   1.000 14.18410 ? 102 SER   A OG  1 
ATOM   819  N N   . LEU   A 1 124 ? 5.10082   6.73091   4.26732   1.000 8.95338  ? 103 LEU   A N   1 
ATOM   820  C CA  . LEU   A 1 124 ? 4.15401   6.15589   5.21400   1.000 11.14494 ? 103 LEU   A CA  1 
ATOM   821  C C   . LEU   A 1 124 ? 4.03318   4.65826   4.98209   1.000 11.37341 ? 103 LEU   A C   1 
ATOM   822  O O   . LEU   A 1 124 ? 3.89804   4.21324   3.83910   1.000 8.16850  ? 103 LEU   A O   1 
ATOM   823  C CB  . LEU   A 1 124 ? 2.77784   6.82319   5.08494   1.000 9.78031  ? 103 LEU   A CB  1 
ATOM   824  C CG  . LEU   A 1 124 ? 1.61969   6.16202   5.83496   1.000 13.40022 ? 103 LEU   A CG  1 
ATOM   825  C CD1 . LEU   A 1 124 ? 1.77984   6.38083   7.32277   1.000 10.15053 ? 103 LEU   A CD1 1 
ATOM   826  C CD2 . LEU   A 1 124 ? 0.28408   6.71222   5.35640   1.000 12.89725 ? 103 LEU   A CD2 1 
ATOM   827  N N   . LEU   A 1 125 ? 4.07681   3.88677   6.06642   1.000 8.05269  ? 104 LEU   A N   1 
ATOM   828  C CA  . LEU   A 1 125 ? 3.83526   2.44831   6.02362   1.000 5.35847  ? 104 LEU   A CA  1 
ATOM   829  C C   . LEU   A 1 125 ? 2.62756   2.15188   6.90137   1.000 10.48844 ? 104 LEU   A C   1 
ATOM   830  O O   . LEU   A 1 125 ? 2.68727   2.31560   8.12498   1.000 5.00698  ? 104 LEU   A O   1 
ATOM   831  C CB  . LEU   A 1 125 ? 5.06278   1.66209   6.48158   1.000 5.89019  ? 104 LEU   A CB  1 
ATOM   832  C CG  . LEU   A 1 125 ? 4.91808   0.13764   6.51670   1.000 6.01256  ? 104 LEU   A CG  1 
ATOM   833  C CD1 . LEU   A 1 125 ? 4.55785   -0.41232  5.14049   1.000 5.95103  ? 104 LEU   A CD1 1 
ATOM   834  C CD2 . LEU   A 1 125 ? 6.20471   -0.49617  7.01829   1.000 6.22658  ? 104 LEU   A CD2 1 
ATOM   835  N N   . ALA   A 1 126 ? 1.53423   1.73073   6.27436   1.000 5.68516  ? 105 ALA   A N   1 
ATOM   836  C CA  . ALA   A 1 126 ? 0.29375   1.41567   6.96657   1.000 7.09574  ? 105 ALA   A CA  1 
ATOM   837  C C   . ALA   A 1 126 ? 0.12211   -0.09430  7.05606   1.000 7.23247  ? 105 ALA   A C   1 
ATOM   838  O O   . ALA   A 1 126 ? 0.46770   -0.82468  6.12192   1.000 7.88029  ? 105 ALA   A O   1 
ATOM   839  C CB  . ALA   A 1 126 ? -0.90406  2.03794   6.24504   1.000 5.46077  ? 105 ALA   A CB  1 
ATOM   840  N N   . SER   A 1 127 ? -0.41096  -0.55975  8.18561   1.000 6.53673  ? 106 SER   A N   1 
ATOM   841  C CA  . SER   A 1 127 ? -0.58745  -1.98561  8.42069   1.000 6.58984  ? 106 SER   A CA  1 
ATOM   842  C C   . SER   A 1 127 ? -1.93650  -2.25525  9.06663   1.000 11.21703 ? 106 SER   A C   1 
ATOM   843  O O   . SER   A 1 127 ? -2.41723  -1.45589  9.87503   1.000 6.14379  ? 106 SER   A O   1 
ATOM   844  C CB  . SER   A 1 127 ? 0.51290   -2.54153  9.32515   1.000 7.95337  ? 106 SER   A CB  1 
ATOM   845  O OG  . SER   A 1 127 ? 0.41372   -2.00072  10.63007  1.000 12.90555 ? 106 SER   A OG  1 
ATOM   846  N N   . VAL   A 1 128 ? -2.53653  -3.39085  8.71265   1.000 8.25414  ? 107 VAL   A N   1 
ATOM   847  C CA  . VAL   A 1 128 ? -3.69642  -3.92512  9.41575   1.000 5.04365  ? 107 VAL   A CA  1 
ATOM   848  C C   . VAL   A 1 128 ? -3.46237  -5.40816  9.66067   1.000 7.81895  ? 107 VAL   A C   1 
ATOM   849  O O   . VAL   A 1 128 ? -3.15951  -6.16118  8.72737   1.000 9.54077  ? 107 VAL   A O   1 
ATOM   850  C CB  . VAL   A 1 128 ? -5.01568  -3.69650  8.64830   1.000 10.96666 ? 107 VAL   A CB  1 
ATOM   851  C CG1 . VAL   A 1 128 ? -5.39070  -2.22951  8.65762   1.000 16.80229 ? 107 VAL   A CG1 1 
ATOM   852  C CG2 . VAL   A 1 128 ? -4.91006  -4.18827  7.22686   1.000 13.44919 ? 107 VAL   A CG2 1 
ATOM   853  N N   . SER   A 1 129 ? -3.58381  -5.82226  10.91756  1.000 9.12574  ? 108 SER   A N   1 
ATOM   854  C CA  . SER   A 1 129 ? -3.40440  -7.22199  11.26493  1.000 9.91968  ? 108 SER   A CA  1 
ATOM   855  C C   . SER   A 1 129 ? -3.94123  -7.45629  12.66171  1.000 11.69409 ? 108 SER   A C   1 
ATOM   856  O O   . SER   A 1 129 ? -3.78085  -6.61194  13.54807  1.000 10.06068 ? 108 SER   A O   1 
ATOM   857  C CB  . SER   A 1 129 ? -1.93293  -7.64227  11.20298  1.000 11.13925 ? 108 SER   A CB  1 
ATOM   858  O OG  . SER   A 1 129 ? -1.79106  -9.01239  11.53866  1.000 7.54285  ? 108 SER   A OG  1 
ATOM   859  N N   . MET   A 1 130 ? -4.55821  -8.61428  12.84646  1.000 6.70465  ? 109 MET   A N   1 
ATOM   860  C CA  . MET   A 1 130 ? -5.00869  -9.05788  14.15159  1.000 13.08737 ? 109 MET   A CA  1 
ATOM   861  C C   . MET   A 1 130 ? -3.92243  -9.80816  14.90934  1.000 11.19240 ? 109 MET   A C   1 
ATOM   862  O O   . MET   A 1 130 ? -4.10651  -10.10701 16.09277  1.000 11.72836 ? 109 MET   A O   1 
ATOM   863  C CB  . MET   A 1 130 ? -6.24790  -9.93233  13.97221  1.000 12.03029 ? 109 MET   A CB  1 
ATOM   864  C CG  . MET   A 1 130 ? -7.44196  -9.12455  13.49656  1.000 9.51753  ? 109 MET   A CG  1 
ATOM   865  S SD  . MET   A 1 130 ? -8.97635  -10.05244 13.48358  1.000 14.39097 ? 109 MET   A SD  1 
ATOM   866  C CE  . MET   A 1 130 ? -8.84110  -10.85766 11.89040  1.000 13.57642 ? 109 MET   A CE  1 
ATOM   867  N N   . THR   A 1 131 ? -2.79444  -10.09564 14.26467  1.000 12.72819 ? 110 THR   A N   1 
ATOM   868  C CA  . THR   A 1 131 ? -1.68145  -10.75202 14.93459  1.000 10.72326 ? 110 THR   A CA  1 
ATOM   869  C C   . THR   A 1 131 ? -1.20390  -9.87179  16.08242  1.000 12.95716 ? 110 THR   A C   1 
ATOM   870  O O   . THR   A 1 131 ? -0.88762  -8.69294  15.85512  1.000 12.17590 ? 110 THR   A O   1 
ATOM   871  C CB  . THR   A 1 131 ? -0.52855  -11.00600 13.96141  1.000 10.75118 ? 110 THR   A CB  1 
ATOM   872  O OG1 . THR   A 1 131 ? -0.92774  -11.95390 12.96235  1.000 10.53864 ? 110 THR   A OG1 1 
ATOM   873  C CG2 . THR   A 1 131 ? 0.69228   -11.53969 14.70687  1.000 13.00719 ? 110 THR   A CG2 1 
ATOM   874  N N   . PRO   A 1 132 ? -1.15238  -10.37944 17.31355  1.000 13.97040 ? 111 PRO   A N   1 
ATOM   875  C CA  . PRO   A 1 132 ? -0.65443  -9.56085  18.42955  1.000 19.10805 ? 111 PRO   A CA  1 
ATOM   876  C C   . PRO   A 1 132 ? 0.78175   -9.13008  18.17995  1.000 14.15637 ? 111 PRO   A C   1 
ATOM   877  O O   . PRO   A 1 132 ? 1.66007   -9.95588  17.92116  1.000 13.73430 ? 111 PRO   A O   1 
ATOM   878  C CB  . PRO   A 1 132 ? -0.77046  -10.50134 19.63550  1.000 16.71875 ? 111 PRO   A CB  1 
ATOM   879  C CG  . PRO   A 1 132 ? -1.81255  -11.49806 19.23692  1.000 16.12279 ? 111 PRO   A CG  1 
ATOM   880  C CD  . PRO   A 1 132 ? -1.60585  -11.70464 17.76431  1.000 13.11049 ? 111 PRO   A CD  1 
ATOM   881  N N   . ALA   A 1 133 ? 1.01408   -7.81767  18.24542  1.000 12.51592 ? 112 ALA   A N   1 
ATOM   882  C CA  . ALA   A 1 133 ? 2.32651   -7.25898  17.92056  1.000 13.81976 ? 112 ALA   A CA  1 
ATOM   883  C C   . ALA   A 1 133 ? 2.46364   -5.90720  18.61732  1.000 12.32623 ? 112 ALA   A C   1 
ATOM   884  O O   . ALA   A 1 133 ? 1.91957   -4.90337  18.14765  1.000 7.13635  ? 112 ALA   A O   1 
ATOM   885  C CB  . ALA   A 1 133 ? 2.50475   -7.12803  16.41454  1.000 10.68209 ? 112 ALA   A CB  1 
ATOM   886  N N   . ILE   A 1 134 ? 3.19288   -5.88958  19.72780  1.000 10.77017 ? 113 ILE   A N   1 
ATOM   887  C CA  . ILE   A 1 134 ? 3.56111   -4.64367  20.39569  1.000 8.87300  ? 113 ILE   A CA  1 
ATOM   888  C C   . ILE   A 1 134 ? 5.06388   -4.69569  20.64810  1.000 8.05872  ? 113 ILE   A C   1 
ATOM   889  O O   . ILE   A 1 134 ? 5.50324   -5.37346  21.58563  1.000 10.99806 ? 113 ILE   A O   1 
ATOM   890  C CB  . ILE   A 1 134 ? 2.76473   -4.43747  21.69462  1.000 10.30594 ? 113 ILE   A CB  1 
ATOM   891  C CG1 . ILE   A 1 134 ? 1.25891   -4.44213  21.40471  1.000 12.22167 ? 113 ILE   A CG1 1 
ATOM   892  C CG2 . ILE   A 1 134 ? 3.16291   -3.12997  22.35852  1.000 13.59379 ? 113 ILE   A CG2 1 
ATOM   893  C CD1 . ILE   A 1 134 ? 0.39153   -4.67898  22.62644  1.000 15.21021 ? 113 ILE   A CD1 1 
ATOM   894  N N   . PRO   A 1 135 ? 5.89698   -4.02006  19.83738  1.000 8.19340  ? 114 PRO   A N   1 
ATOM   895  C CA  . PRO   A 1 135 ? 5.54673   -3.08781  18.75829  1.000 9.32582  ? 114 PRO   A CA  1 
ATOM   896  C C   . PRO   A 1 135 ? 4.90493   -3.73177  17.53079  1.000 7.83358  ? 114 PRO   A C   1 
ATOM   897  O O   . PRO   A 1 135 ? 5.02272   -4.93683  17.30988  1.000 7.10817  ? 114 PRO   A O   1 
ATOM   898  C CB  . PRO   A 1 135 ? 6.89750   -2.47771  18.38144  1.000 7.87849  ? 114 PRO   A CB  1 
ATOM   899  C CG  . PRO   A 1 135 ? 7.88043   -3.55003  18.68580  1.000 7.85993  ? 114 PRO   A CG  1 
ATOM   900  C CD  . PRO   A 1 135 ? 7.35020   -4.26285  19.90076  1.000 7.32192  ? 114 PRO   A CD  1 
ATOM   901  N N   . SER   A 1 136 ? 4.23898   -2.89861  16.73633  1.000 7.22519  ? 115 SER   A N   1 
ATOM   902  C CA  . SER   A 1 136 ? 3.45410   -3.35674  15.60214  1.000 6.09491  ? 115 SER   A CA  1 
ATOM   903  C C   . SER   A 1 136 ? 4.34310   -3.99822  14.53769  1.000 11.82473 ? 115 SER   A C   1 
ATOM   904  O O   . SER   A 1 136 ? 5.57369   -3.88273  14.54955  1.000 8.11507  ? 115 SER   A O   1 
ATOM   905  C CB  . SER   A 1 136 ? 2.67970   -2.19240  14.99345  1.000 7.30429  ? 115 SER   A CB  1 
ATOM   906  O OG  . SER   A 1 136 ? 3.56514   -1.27269  14.37523  1.000 8.72021  ? 115 SER   A OG  1 
ATOM   907  N N   . LEU   A 1 137 ? 3.68531   -4.67632  13.59372  1.000 8.54131  ? 116 LEU   A N   1 
ATOM   908  C CA  . LEU   A 1 137 ? 4.40352   -5.34459  12.51448  1.000 9.56978  ? 116 LEU   A CA  1 
ATOM   909  C C   . LEU   A 1 137 ? 5.17976   -4.34808  11.66483  1.000 7.27833  ? 116 LEU   A C   1 
ATOM   910  O O   . LEU   A 1 137 ? 6.30640   -4.62893  11.23986  1.000 11.76161 ? 116 LEU   A O   1 
ATOM   911  C CB  . LEU   A 1 137 ? 3.42156   -6.13263  11.64705  1.000 7.36858  ? 116 LEU   A CB  1 
ATOM   912  C CG  . LEU   A 1 137 ? 2.71894   -7.31743  12.30995  1.000 10.40340 ? 116 LEU   A CG  1 
ATOM   913  C CD1 . LEU   A 1 137 ? 1.64535   -7.87657  11.38975  1.000 8.01824  ? 116 LEU   A CD1 1 
ATOM   914  C CD2 . LEU   A 1 137 ? 3.72239   -8.39372  12.65584  1.000 7.59135  ? 116 LEU   A CD2 1 
ATOM   915  N N   . ASP   A 1 138 ? 4.58965   -3.18094  11.39835  1.000 4.30533  ? 117 ASP   A N   1 
ATOM   916  C CA  . ASP   A 1 138 ? 5.24393   -2.19540  10.54405  1.000 7.19393  ? 117 ASP   A CA  1 
ATOM   917  C C   . ASP   A 1 138 ? 6.51897   -1.66239  11.18495  1.000 10.33298 ? 117 ASP   A C   1 
ATOM   918  O O   . ASP   A 1 138 ? 7.50009   -1.38604  10.48580  1.000 6.93662  ? 117 ASP   A O   1 
ATOM   919  C CB  . ASP   A 1 138 ? 4.27900   -1.05503  10.22811  1.000 10.32204 ? 117 ASP   A CB  1 
ATOM   920  C CG  . ASP   A 1 138 ? 3.50346   -0.60010  11.44439  1.000 10.76790 ? 117 ASP   A CG  1 
ATOM   921  O OD1 . ASP   A 1 138 ? 2.55069   -1.30676  11.83768  1.000 12.53684 ? 117 ASP   A OD1 1 
ATOM   922  O OD2 . ASP   A 1 138 ? 3.84586   0.45790   12.00941  1.000 10.26546 ? 117 ASP   A OD2 1 
ATOM   923  N N   . GLY   A 1 139 ? 6.52158   -1.49635  12.50926  1.000 7.07433  ? 118 GLY   A N   1 
ATOM   924  C CA  . GLY   A 1 139 ? 7.74566   -1.10160  13.18595  1.000 7.99217  ? 118 GLY   A CA  1 
ATOM   925  C C   . GLY   A 1 139 ? 8.82309   -2.16550  13.09680  1.000 9.33846  ? 118 GLY   A C   1 
ATOM   926  O O   . GLY   A 1 139 ? 9.98536   -1.86410  12.80864  1.000 13.45326 ? 118 GLY   A O   1 
ATOM   927  N N   . ARG   A 1 140 ? 8.44990   -3.42690  13.32251  1.000 7.69847  ? 119 ARG   A N   1 
ATOM   928  C CA  . ARG   A 1 140 ? 9.42582   -4.51008  13.26628  1.000 9.99992  ? 119 ARG   A CA  1 
ATOM   929  C C   . ARG   A 1 140 ? 10.00708  -4.67064  11.86903  1.000 10.35469 ? 119 ARG   A C   1 
ATOM   930  O O   . ARG   A 1 140 ? 11.16450  -5.07913  11.72203  1.000 10.26449 ? 119 ARG   A O   1 
ATOM   931  C CB  . ARG   A 1 140 ? 8.78550   -5.81715  13.73088  1.000 8.85922  ? 119 ARG   A CB  1 
ATOM   932  C CG  . ARG   A 1 140 ? 8.30414   -5.78730  15.17081  1.000 8.70578  ? 119 ARG   A CG  1 
ATOM   933  C CD  . ARG   A 1 140 ? 7.52966   -7.04228  15.51552  1.000 12.02221 ? 119 ARG   A CD  1 
ATOM   934  N NE  . ARG   A 1 140 ? 6.83817   -6.91899  16.79283  1.000 15.72524 ? 119 ARG   A NE  1 
ATOM   935  C CZ  . ARG   A 1 140 ? 7.14845   -7.60912  17.88154  1.000 13.74007 ? 119 ARG   A CZ  1 
ATOM   936  N NH1 . ARG   A 1 140 ? 8.12196   -8.50449  17.87820  1.000 15.43034 ? 119 ARG   A NH1 1 
ATOM   937  N NH2 . ARG   A 1 140 ? 6.46393   -7.39594  19.00168  1.000 15.02801 ? 119 ARG   A NH2 1 
ATOM   938  N N   . LEU   A 1 141 ? 9.22564   -4.34705  10.83633  1.000 8.97758  ? 120 LEU   A N   1 
ATOM   939  C CA  . LEU   A 1 141 ? 9.68608   -4.49208  9.46071   1.000 11.50143 ? 120 LEU   A CA  1 
ATOM   940  C C   . LEU   A 1 141 ? 10.79595  -3.51165  9.09583   1.000 10.46010 ? 120 LEU   A C   1 
ATOM   941  O O   . LEU   A 1 141 ? 11.54570  -3.77539  8.14856   1.000 11.46644 ? 120 LEU   A O   1 
ATOM   942  C CB  . LEU   A 1 141 ? 8.50770   -4.32166  8.50024   1.000 10.13324 ? 120 LEU   A CB  1 
ATOM   943  C CG  . LEU   A 1 141 ? 7.55713   -5.51271  8.36805   1.000 12.92013 ? 120 LEU   A CG  1 
ATOM   944  C CD1 . LEU   A 1 141 ? 6.26793   -5.08361  7.69063   1.000 9.78641  ? 120 LEU   A CD1 1 
ATOM   945  C CD2 . LEU   A 1 141 ? 8.21080   -6.65430  7.59766   1.000 12.83459 ? 120 LEU   A CD2 1 
ATOM   946  N N   . MET   A 1 142 ? 10.93156  -2.39239  9.81185   1.000 10.86847 ? 121 MET   A N   1 
ATOM   947  C CA  . MET   A 1 142 ? 12.01354  -1.47615  9.46617   1.000 13.41240 ? 121 MET   A CA  1 
ATOM   948  C C   . MET   A 1 142 ? 13.39418  -2.02804  9.81340   1.000 12.30324 ? 121 MET   A C   1 
ATOM   949  O O   . MET   A 1 142 ? 14.39528  -1.43781  9.39522   1.000 12.85145 ? 121 MET   A O   1 
ATOM   950  C CB  . MET   A 1 142 ? 11.80335  -0.09955  10.11691  1.000 9.24215  ? 121 MET   A CB  1 
ATOM   951  C CG  . MET   A 1 142 ? 10.34224  0.34164   10.23087  1.000 9.43198  ? 121 MET   A CG  1 
ATOM   952  S SD  . MET   A 1 142 ? 10.10551  1.89347   11.13425  1.000 11.86566 ? 121 MET   A SD  1 
ATOM   953  C CE  . MET   A 1 142 ? 11.58543  2.79772   10.67142  1.000 10.11575 ? 121 MET   A CE  1 
ATOM   954  N N   . ASN   A 1 143 ? 13.47837  -3.13394  10.55332  1.000 13.25609 ? 122 ASN   A N   1 
ATOM   955  C CA  . ASN   A 1 143 ? 14.74205  -3.83766  10.73554  1.000 14.03969 ? 122 ASN   A CA  1 
ATOM   956  C C   . ASN   A 1 143 ? 15.02501  -4.84890  9.63313   1.000 17.32753 ? 122 ASN   A C   1 
ATOM   957  O O   . ASN   A 1 143 ? 16.13742  -5.38410  9.57606   1.000 17.47265 ? 122 ASN   A O   1 
ATOM   958  C CB  . ASN   A 1 143 ? 14.76969  -4.55636  12.08965  1.000 11.48592 ? 122 ASN   A CB  1 
ATOM   959  C CG  . ASN   A 1 143 ? 14.77459  -3.59670  13.25863  1.000 9.66713  ? 122 ASN   A CG  1 
ATOM   960  O OD1 . ASN   A 1 143 ? 15.41892  -2.54928  13.21236  1.000 7.77922  ? 122 ASN   A OD1 1 
ATOM   961  N ND2 . ASN   A 1 143 ? 14.05690  -3.95035  14.31683  1.000 7.48597  ? 122 ASN   A ND2 1 
ATOM   962  N N   . ARG   A 1 144 ? 14.05128  -5.12864  8.76806   1.000 15.44792 ? 123 ARG   A N   1 
ATOM   963  C CA  . ARG   A 1 144 ? 14.24261  -6.02917  7.63785   1.000 10.10834 ? 123 ARG   A CA  1 
ATOM   964  C C   . ARG   A 1 144 ? 14.33282  -5.30924  6.30126   1.000 17.79961 ? 123 ARG   A C   1 
ATOM   965  O O   . ARG   A 1 144 ? 14.94321  -5.83739  5.37046   1.000 12.91729 ? 123 ARG   A O   1 
ATOM   966  C CB  . ARG   A 1 144 ? 13.09826  -7.04818  7.56426   1.000 13.67670 ? 123 ARG   A CB  1 
ATOM   967  C CG  . ARG   A 1 144 ? 13.08016  -8.07291  8.67702   1.000 15.05428 ? 123 ARG   A CG  1 
ATOM   968  C CD  . ARG   A 1 144 ? 11.75403  -8.80518  8.66383   1.000 15.56692 ? 123 ARG   A CD  1 
ATOM   969  N NE  . ARG   A 1 144 ? 11.68999  -9.86326  9.66238   1.000 18.67381 ? 123 ARG   A NE  1 
ATOM   970  C CZ  . ARG   A 1 144 ? 11.25367  -11.08981 9.41373   1.000 17.88820 ? 123 ARG   A CZ  1 
ATOM   971  N NH1 . ARG   A 1 144 ? 10.86719  -11.45288 8.20026   1.000 19.65202 ? 123 ARG   A NH1 1 
ATOM   972  N NH2 . ARG   A 1 144 ? 11.20755  -11.97496 10.40434  1.000 16.35690 ? 123 ARG   A NH2 1 
ATOM   973  N N   . ILE   A 1 145 ? 13.73612  -4.12988  6.18404   1.000 11.70623 ? 124 ILE   A N   1 
ATOM   974  C CA  . ILE   A 1 145 ? 13.71717  -3.35976  4.95044   1.000 11.48363 ? 124 ILE   A CA  1 
ATOM   975  C C   . ILE   A 1 145 ? 14.28244  -1.98014  5.27418   1.000 14.01727 ? 124 ILE   A C   1 
ATOM   976  O O   . ILE   A 1 145 ? 13.85614  -1.36710  6.25468   1.000 12.88833 ? 124 ILE   A O   1 
ATOM   977  C CB  . ILE   A 1 145 ? 12.30342  -3.24175  4.35213   1.000 10.43462 ? 124 ILE   A CB  1 
ATOM   978  C CG1 . ILE   A 1 145 ? 11.79331  -4.61361  3.93020   1.000 10.61626 ? 124 ILE   A CG1 1 
ATOM   979  C CG2 . ILE   A 1 145 ? 12.29905  -2.28157  3.18017   1.000 10.21304 ? 124 ILE   A CG2 1 
ATOM   980  C CD1 . ILE   A 1 145 ? 10.27869  -4.69131  3.84906   1.000 9.23271  ? 124 ILE   A CD1 1 
ATOM   981  N N   . PRO   A 1 146 ? 15.24805  -1.46656  4.49452   1.000 15.15042 ? 125 PRO   A N   1 
ATOM   982  C CA  . PRO   A 1 146 ? 15.91057  -0.20855  4.87218   1.000 16.69687 ? 125 PRO   A CA  1 
ATOM   983  C C   . PRO   A 1 146 ? 15.05211  1.02074   4.62911   1.000 12.50515 ? 125 PRO   A C   1 
ATOM   984  O O   . PRO   A 1 146 ? 15.41618  1.90443   3.84693   1.000 13.18640 ? 125 PRO   A O   1 
ATOM   985  C CB  . PRO   A 1 146 ? 17.16787  -0.20058  3.99250   1.000 15.19898 ? 125 PRO   A CB  1 
ATOM   986  C CG  . PRO   A 1 146 ? 16.79224  -1.00962  2.80553   1.000 16.64252 ? 125 PRO   A CG  1 
ATOM   987  C CD  . PRO   A 1 146 ? 15.82697  -2.05641  3.27244   1.000 12.53389 ? 125 PRO   A CD  1 
ATOM   988  N N   . PHE   A 1 147 ? 13.91051  1.08746   5.30371   1.000 8.33639  ? 126 PHE   A N   1 
ATOM   989  C CA  . PHE   A 1 147 ? 13.14802  2.32328   5.34035   1.000 11.12019 ? 126 PHE   A CA  1 
ATOM   990  C C   . PHE   A 1 147 ? 13.92619  3.39049   6.10019   1.000 7.21315  ? 126 PHE   A C   1 
ATOM   991  O O   . PHE   A 1 147 ? 14.78033  3.09071   6.93622   1.000 11.97779 ? 126 PHE   A O   1 
ATOM   992  C CB  . PHE   A 1 147 ? 11.79746  2.11509   6.02411   1.000 12.83317 ? 126 PHE   A CB  1 
ATOM   993  C CG  . PHE   A 1 147 ? 10.86181  1.22163   5.27231   1.000 10.04792 ? 126 PHE   A CG  1 
ATOM   994  C CD1 . PHE   A 1 147 ? 10.28617  1.63814   4.08521   1.000 14.56096 ? 126 PHE   A CD1 1 
ATOM   995  C CD2 . PHE   A 1 147 ? 10.55434  -0.03721  5.75800   1.000 10.13065 ? 126 PHE   A CD2 1 
ATOM   996  C CE1 . PHE   A 1 147 ? 9.41927   0.81521   3.39619   1.000 8.30193  ? 126 PHE   A CE1 1 
ATOM   997  C CE2 . PHE   A 1 147 ? 9.69005   -0.86416  5.07387   1.000 9.85436  ? 126 PHE   A CE2 1 
ATOM   998  C CZ  . PHE   A 1 147 ? 9.12240   -0.43845  3.89201   1.000 3.94610  ? 126 PHE   A CZ  1 
ATOM   999  N N   . SER   A 1 148 ? 13.61569  4.65130   5.80927   1.000 9.40884  ? 127 SER   A N   1 
ATOM   1000 C CA  . SER   A 1 148 ? 14.16869  5.74342   6.59983   1.000 13.71615 ? 127 SER   A CA  1 
ATOM   1001 C C   . SER   A 1 148 ? 13.74361  5.59976   8.05712   1.000 9.73711  ? 127 SER   A C   1 
ATOM   1002 O O   . SER   A 1 148 ? 12.62822  5.16610   8.35446   1.000 8.39706  ? 127 SER   A O   1 
ATOM   1003 C CB  . SER   A 1 148 ? 13.70522  7.09108   6.04370   1.000 14.85109 ? 127 SER   A CB  1 
ATOM   1004 O OG  . SER   A 1 148 ? 13.70844  8.08991   7.05036   1.000 26.85685 ? 127 SER   A OG  1 
ATOM   1005 N N   . SER   A 1 149 ? 14.65191  5.94699   8.97342   1.000 9.69002  ? 128 SER   A N   1 
ATOM   1006 C CA  . SER   A 1 149 ? 14.34696  5.83167   10.39642  1.000 13.80437 ? 128 SER   A CA  1 
ATOM   1007 C C   . SER   A 1 149 ? 13.20398  6.74929   10.81738  1.000 8.90330  ? 128 SER   A C   1 
ATOM   1008 O O   . SER   A 1 149 ? 12.56309  6.49298   11.84365  1.000 9.25052  ? 128 SER   A O   1 
ATOM   1009 C CB  . SER   A 1 149 ? 15.59786  6.12976   11.22779  1.000 18.79758 ? 128 SER   A CB  1 
ATOM   1010 O OG  . SER   A 1 149 ? 16.36617  4.95446   11.43623  1.000 22.69749 ? 128 SER   A OG  1 
ATOM   1011 N N   . THR   A 1 150 ? 12.93519  7.80776   10.05057  1.000 9.77183  ? 129 THR   A N   1 
ATOM   1012 C CA  . THR   A 1 150 ? 11.82210  8.71094   10.30459  1.000 9.18440  ? 129 THR   A CA  1 
ATOM   1013 C C   . THR   A 1 150 ? 10.56789  8.32863   9.52667   1.000 9.56632  ? 129 THR   A C   1 
ATOM   1014 O O   . THR   A 1 150 ? 9.70696   9.18676   9.29762   1.000 7.84442  ? 129 THR   A O   1 
ATOM   1015 C CB  . THR   A 1 150 ? 12.21457  10.15329  9.97258   1.000 14.25368 ? 129 THR   A CB  1 
ATOM   1016 O OG1 . THR   A 1 150 ? 12.68828  10.22659  8.62270   1.000 14.72768 ? 129 THR   A OG1 1 
ATOM   1017 C CG2 . THR   A 1 150 ? 13.30384  10.64610  10.92023  1.000 11.51313 ? 129 THR   A CG2 1 
ATOM   1018 N N   . LEU   A 1 151 ? 10.45212  7.06765   9.11304   1.000 10.27724 ? 130 LEU   A N   1 
ATOM   1019 C CA  . LEU   A 1 151 ? 9.25831   6.60602   8.41451   1.000 7.63786  ? 130 LEU   A CA  1 
ATOM   1020 C C   . LEU   A 1 151 ? 8.01795   6.83151   9.26924   1.000 8.19560  ? 130 LEU   A C   1 
ATOM   1021 O O   . LEU   A 1 151 ? 8.01196   6.52840   10.46555  1.000 7.69945  ? 130 LEU   A O   1 
ATOM   1022 C CB  . LEU   A 1 151 ? 9.39738   5.12195   8.07086   1.000 4.63646  ? 130 LEU   A CB  1 
ATOM   1023 C CG  . LEU   A 1 151 ? 8.23267   4.43240   7.35887   1.000 8.22694  ? 130 LEU   A CG  1 
ATOM   1024 C CD1 . LEU   A 1 151 ? 8.13459   4.87018   5.90631   1.000 8.45784  ? 130 LEU   A CD1 1 
ATOM   1025 C CD2 . LEU   A 1 151 ? 8.36810   2.91941   7.45834   1.000 7.25079  ? 130 LEU   A CD2 1 
ATOM   1026 N N   . LYS   A 1 152 ? 6.97439   7.38357   8.65435   1.000 8.05095  ? 131 LYS   A N   1 
ATOM   1027 C CA  . LYS   A 1 152 ? 5.67575   7.48084   9.30369   1.000 9.80776  ? 131 LYS   A CA  1 
ATOM   1028 C C   . LYS   A 1 152 ? 4.96540   6.13713   9.22427   1.000 11.04941 ? 131 LYS   A C   1 
ATOM   1029 O O   . LYS   A 1 152 ? 5.03843   5.43749   8.20953   1.000 7.72766  ? 131 LYS   A O   1 
ATOM   1030 C CB  . LYS   A 1 152 ? 4.82123   8.56551   8.64788   1.000 7.86221  ? 131 LYS   A CB  1 
ATOM   1031 C CG  . LYS   A 1 152 ? 5.14194   9.97916   9.11010   1.000 12.67071 ? 131 LYS   A CG  1 
ATOM   1032 C CD  . LYS   A 1 152 ? 4.17482   10.98782  8.51820   1.000 14.54194 ? 131 LYS   A CD  1 
ATOM   1033 C CE  . LYS   A 1 152 ? 4.62702   12.41122  8.79232   1.000 16.00061 ? 131 LYS   A CE  1 
ATOM   1034 N NZ  . LYS   A 1 152 ? 3.97287   13.38579  7.86906   1.000 15.07243 ? 131 LYS   A NZ  1 
ATOM   1035 N N   . ARG   A 1 153 ? 4.27717   5.77520   10.30169  1.000 8.67320  ? 132 ARG   A N   1 
ATOM   1036 C CA  . ARG   A 1 153 ? 3.62899   4.47835   10.39848  1.000 9.32993  ? 132 ARG   A CA  1 
ATOM   1037 C C   . ARG   A 1 153 ? 2.16319   4.65992   10.75549  1.000 8.16329  ? 132 ARG   A C   1 
ATOM   1038 O O   . ARG   A 1 153 ? 1.78367   5.62724   11.41921  1.000 7.17722  ? 132 ARG   A O   1 
ATOM   1039 C CB  . ARG   A 1 153 ? 4.32851   3.59583   11.43201  1.000 11.13868 ? 132 ARG   A CB  1 
ATOM   1040 C CG  . ARG   A 1 153 ? 5.80359   3.39308   11.11445  1.000 10.58662 ? 132 ARG   A CG  1 
ATOM   1041 C CD  . ARG   A 1 153 ? 6.42282   2.36024   12.01863  1.000 19.65902 ? 132 ARG   A CD  1 
ATOM   1042 N NE  . ARG   A 1 153 ? 6.65118   2.88262   13.35864  1.000 15.91761 ? 132 ARG   A NE  1 
ATOM   1043 C CZ  . ARG   A 1 153 ? 6.23901   2.28469   14.46703  1.000 14.76279 ? 132 ARG   A CZ  1 
ATOM   1044 N NH1 . ARG   A 1 153 ? 5.55970   1.15126   14.42597  1.000 12.48260 ? 132 ARG   A NH1 1 
ATOM   1045 N NH2 . ARG   A 1 153 ? 6.51479   2.83800   15.64524  1.000 12.64796 ? 132 ARG   A NH2 1 
ATOM   1046 N N   . LEU   A 1 154 ? 1.33659   3.73496   10.27657  1.000 7.58201  ? 133 LEU   A N   1 
ATOM   1047 C CA  . LEU   A 1 154 ? -0.09871  3.73187   10.55317  1.000 6.33216  ? 133 LEU   A CA  1 
ATOM   1048 C C   . LEU   A 1 154 ? -0.50636  2.31265   10.91648  1.000 7.40822  ? 133 LEU   A C   1 
ATOM   1049 O O   . LEU   A 1 154 ? -1.06282  1.58001   10.08769  1.000 5.41178  ? 133 LEU   A O   1 
ATOM   1050 C CB  . LEU   A 1 154 ? -0.90247  4.25431   9.36349   1.000 9.22237  ? 133 LEU   A CB  1 
ATOM   1051 C CG  . LEU   A 1 154 ? -2.33848  4.67444   9.69047   1.000 11.35203 ? 133 LEU   A CG  1 
ATOM   1052 C CD1 . LEU   A 1 154 ? -2.36331  5.69717   10.82429  1.000 6.94635  ? 133 LEU   A CD1 1 
ATOM   1053 C CD2 . LEU   A 1 154 ? -3.05127  5.20147   8.45418   1.000 7.32123  ? 133 LEU   A CD2 1 
ATOM   1054 N N   . PRO   A 1 155 ? -0.22562  1.88226   12.14310  1.000 11.46666 ? 134 PRO   A N   1 
ATOM   1055 C CA  . PRO   A 1 155 ? -0.61415  0.53266   12.57256  1.000 10.17701 ? 134 PRO   A CA  1 
ATOM   1056 C C   . PRO   A 1 155 ? -2.05528  0.51978   13.05538  1.000 10.39872 ? 134 PRO   A C   1 
ATOM   1057 O O   . PRO   A 1 155 ? -2.38149  1.09564   14.09725  1.000 8.89731  ? 134 PRO   A O   1 
ATOM   1058 C CB  . PRO   A 1 155 ? 0.37136   0.23656   13.71135  1.000 8.73824  ? 134 PRO   A CB  1 
ATOM   1059 C CG  . PRO   A 1 155 ? 0.75259   1.58845   14.25596  1.000 10.92288 ? 134 PRO   A CG  1 
ATOM   1060 C CD  . PRO   A 1 155 ? 0.45724   2.63617   13.20879  1.000 10.97491 ? 134 PRO   A CD  1 
ATOM   1061 N N   . MET   A 1 156 ? -2.92166  -0.15457  12.31093  1.000 7.39445  ? 135 MET   A N   1 
ATOM   1062 C CA  . MET   A 1 156 ? -4.32285  -0.23017  12.69090  1.000 9.14832  ? 135 MET   A CA  1 
ATOM   1063 C C   . MET   A 1 156 ? -4.69573  -1.65316  13.08504  1.000 9.38701  ? 135 MET   A C   1 
ATOM   1064 O O   . MET   A 1 156 ? -4.08086  -2.62538  12.63937  1.000 11.66276 ? 135 MET   A O   1 
ATOM   1065 C CB  . MET   A 1 156 ? -5.24133  0.26820   11.56757  1.000 6.82341  ? 135 MET   A CB  1 
ATOM   1066 C CG  . MET   A 1 156 ? -4.88200  1.64669   11.02537  1.000 8.30763  ? 135 MET   A CG  1 
ATOM   1067 S SD  . MET   A 1 156 ? -5.41447  1.92339   9.32441   1.000 13.57085 ? 135 MET   A SD  1 
ATOM   1068 C CE  . MET   A 1 156 ? -4.07110  1.19960   8.38144   1.000 5.98313  ? 135 MET   A CE  1 
ATOM   1069 N N   . ASN   A 1 157 ? -5.70562  -1.75485  13.94457  1.000 12.40910 ? 136 ASN   A N   1 
ATOM   1070 C CA  . ASN   A 1 157 ? -6.22745  -3.02904  14.41330  1.000 8.92428  ? 136 ASN   A CA  1 
ATOM   1071 C C   . ASN   A 1 157 ? -7.68762  -2.81472  14.79225  1.000 10.98570 ? 136 ASN   A C   1 
ATOM   1072 O O   . ASN   A 1 157 ? -8.24402  -1.72901  14.60372  1.000 10.76812 ? 136 ASN   A O   1 
ATOM   1073 C CB  . ASN   A 1 157 ? -5.39977  -3.56728  15.58773  1.000 12.07608 ? 136 ASN   A CB  1 
ATOM   1074 C CG  . ASN   A 1 157 ? -5.51970  -5.07703  15.75550  1.000 20.85330 ? 136 ASN   A CG  1 
ATOM   1075 O OD1 . ASN   A 1 157 ? -6.49796  -5.69234  15.32747  1.000 16.16297 ? 136 ASN   A OD1 1 
ATOM   1076 N ND2 . ASN   A 1 157 ? -4.51998  -5.67809  16.39034  1.000 21.53502 ? 136 ASN   A ND2 1 
ATOM   1077 N N   . GLY   A 1 158 ? -8.31171  -3.86130  15.32355  1.000 11.17369 ? 137 GLY   A N   1 
ATOM   1078 C CA  . GLY   A 1 158 ? -9.70376  -3.76475  15.70875  1.000 11.25735 ? 137 GLY   A CA  1 
ATOM   1079 C C   . GLY   A 1 158 ? -10.67209 -3.64141  14.55620  1.000 12.60314 ? 137 GLY   A C   1 
ATOM   1080 O O   . GLY   A 1 158 ? -11.81076 -3.20991  14.76090  1.000 9.63999  ? 137 GLY   A O   1 
ATOM   1081 N N   . VAL   A 1 159 ? -10.25376 -4.01143  13.34741  1.000 10.05323 ? 138 VAL   A N   1 
ATOM   1082 C CA  . VAL   A 1 159 ? -11.10886 -3.91633  12.17128  1.000 9.48788  ? 138 VAL   A CA  1 
ATOM   1083 C C   . VAL   A 1 159 ? -11.34834 -5.25923  11.49366  1.000 9.73036  ? 138 VAL   A C   1 
ATOM   1084 O O   . VAL   A 1 159 ? -12.28459 -5.36327  10.68408  1.000 10.43429 ? 138 VAL   A O   1 
ATOM   1085 C CB  . VAL   A 1 159 ? -10.54011 -2.90512  11.15389  1.000 10.35633 ? 138 VAL   A CB  1 
ATOM   1086 C CG1 . VAL   A 1 159 ? -10.61456 -1.49482  11.71787  1.000 12.49826 ? 138 VAL   A CG1 1 
ATOM   1087 C CG2 . VAL   A 1 159 ? -9.10294  -3.26063  10.81459  1.000 7.47409  ? 138 VAL   A CG2 1 
ATOM   1088 N N   . GLY   A 1 160 ? -10.54140 -6.28206  11.77150  1.000 8.74768  ? 139 GLY   A N   1 
ATOM   1089 C CA  . GLY   A 1 160 ? -10.82226 -7.61917  11.26593  1.000 8.16206  ? 139 GLY   A CA  1 
ATOM   1090 C C   . GLY   A 1 160 ? -10.84879 -7.68827  9.74948   1.000 9.96278  ? 139 GLY   A C   1 
ATOM   1091 O O   . GLY   A 1 160 ? -9.98381  -7.13236  9.06192   1.000 9.03574  ? 139 GLY   A O   1 
ATOM   1092 N N   . CYS   A 1 161 ? -11.87008 -8.37568  9.22033   1.000 7.91776  ? 140 CYS   A N   1 
ATOM   1093 C CA  . CYS   A 1 161 ? -11.98172 -8.62334  7.78447   1.000 9.01688  ? 140 CYS   A CA  1 
ATOM   1094 C C   . CYS   A 1 161 ? -12.14835 -7.34720  6.97123   1.000 8.64592  ? 140 CYS   A C   1 
ATOM   1095 O O   . CYS   A 1 161 ? -11.92011 -7.36970  5.75830   1.000 10.95423 ? 140 CYS   A O   1 
ATOM   1096 C CB  . CYS   A 1 161 ? -13.15959 -9.55828  7.49490   1.000 11.03570 ? 140 CYS   A CB  1 
ATOM   1097 S SG  . CYS   A 1 161 ? -12.97444 -11.24972 8.09656   1.000 29.31297 ? 140 CYS   A SG  1 
ATOM   1098 N N   . MET   A 1 162 ? -12.55399 -6.24503  7.59836   1.000 7.82584  ? 141 MET   A N   1 
ATOM   1099 C CA  . MET   A 1 162 ? -12.65981 -4.96883  6.90287   1.000 9.23076  ? 141 MET   A CA  1 
ATOM   1100 C C   . MET   A 1 162 ? -11.30905 -4.31216  6.64609   1.000 10.54065 ? 141 MET   A C   1 
ATOM   1101 O O   . MET   A 1 162 ? -11.25627 -3.30797  5.92668   1.000 10.08941 ? 141 MET   A O   1 
ATOM   1102 C CB  . MET   A 1 162 ? -13.52296 -3.99922  7.70970   1.000 13.54958 ? 141 MET   A CB  1 
ATOM   1103 C CG  . MET   A 1 162 ? -14.14855 -2.89420  6.88394   1.000 17.43936 ? 141 MET   A CG  1 
ATOM   1104 S SD  . MET   A 1 162 ? -15.19876 -1.83916  7.88949   1.000 14.53710 ? 141 MET   A SD  1 
ATOM   1105 C CE  . MET   A 1 162 ? -14.05984 -1.38630  9.19630   1.000 14.63380 ? 141 MET   A CE  1 
ATOM   1106 N N   . GLY   A 1 163 ? -10.22597 -4.86385  7.19630   1.000 9.02676  ? 142 GLY   A N   1 
ATOM   1107 C CA  . GLY   A 1 163 ? -8.99011  -4.10393  7.32301   1.000 14.73648 ? 142 GLY   A CA  1 
ATOM   1108 C C   . GLY   A 1 163 ? -8.42202  -3.62030  6.00318   1.000 7.70980  ? 142 GLY   A C   1 
ATOM   1109 O O   . GLY   A 1 163 ? -7.97158  -2.47753  5.89912   1.000 9.09405  ? 142 GLY   A O   1 
ATOM   1110 N N   . GLY   A 1 164 ? -8.42172  -4.48229  4.98297   1.000 4.76579  ? 143 GLY   A N   1 
ATOM   1111 C CA  . GLY   A 1 164 ? -7.81001  -4.10637  3.71649   1.000 8.24072  ? 143 GLY   A CA  1 
ATOM   1112 C C   . GLY   A 1 164 ? -8.48113  -2.90621  3.07864   1.000 8.90507  ? 143 GLY   A C   1 
ATOM   1113 O O   . GLY   A 1 164 ? -7.81707  -1.94290  2.68470   1.000 8.79298  ? 143 GLY   A O   1 
ATOM   1114 N N   . ALA   A 1 165 ? -9.81353  -2.94097  2.98603   1.000 6.25760  ? 144 ALA   A N   1 
ATOM   1115 C CA  . ALA   A 1 165 ? -10.54996 -1.78870  2.47952   1.000 6.68191  ? 144 ALA   A CA  1 
ATOM   1116 C C   . ALA   A 1 165 ? -10.40396 -0.59620  3.41226   1.000 6.46469  ? 144 ALA   A C   1 
ATOM   1117 O O   . ALA   A 1 165 ? -10.24803 0.54277   2.95826   1.000 7.31199  ? 144 ALA   A O   1 
ATOM   1118 C CB  . ALA   A 1 165 ? -12.02387 -2.14589  2.29732   1.000 8.44459  ? 144 ALA   A CB  1 
ATOM   1119 N N   . PHE   A 1 166 ? -10.44479 -0.84609  4.72194   1.000 7.49524  ? 145 PHE   A N   1 
ATOM   1120 C CA  . PHE   A 1 166 ? -10.28978 0.22809   5.69526   1.000 8.15485  ? 145 PHE   A CA  1 
ATOM   1121 C C   . PHE   A 1 166 ? -8.94053  0.91737   5.54413   1.000 5.87000  ? 145 PHE   A C   1 
ATOM   1122 O O   . PHE   A 1 166 ? -8.85796  2.15117   5.57939   1.000 5.61938  ? 145 PHE   A O   1 
ATOM   1123 C CB  . PHE   A 1 166 ? -10.45344 -0.33911  7.10515   1.000 5.97891  ? 145 PHE   A CB  1 
ATOM   1124 C CG  . PHE   A 1 166 ? -10.49073 0.70191   8.18116   1.000 8.83321  ? 145 PHE   A CG  1 
ATOM   1125 C CD1 . PHE   A 1 166 ? -11.66430 1.37939   8.46560   1.000 9.37267  ? 145 PHE   A CD1 1 
ATOM   1126 C CD2 . PHE   A 1 166 ? -9.35762  0.99123   8.92077   1.000 8.76250  ? 145 PHE   A CD2 1 
ATOM   1127 C CE1 . PHE   A 1 166 ? -11.70419 2.33306   9.46359   1.000 10.36468 ? 145 PHE   A CE1 1 
ATOM   1128 C CE2 . PHE   A 1 166 ? -9.39256  1.94520   9.92153   1.000 11.32708 ? 145 PHE   A CE2 1 
ATOM   1129 C CZ  . PHE   A 1 166 ? -10.56910 2.61565   10.19110  1.000 6.52349  ? 145 PHE   A CZ  1 
ATOM   1130 N N   . GLY   A 1 167 ? -7.87467  0.13539   5.36143   1.000 4.52527  ? 146 GLY   A N   1 
ATOM   1131 C CA  . GLY   A 1 167 ? -6.54907  0.71927   5.23612   1.000 5.43188  ? 146 GLY   A CA  1 
ATOM   1132 C C   . GLY   A 1 167 ? -6.39669  1.57950   3.99692   1.000 6.89425  ? 146 GLY   A C   1 
ATOM   1133 O O   . GLY   A 1 167 ? -5.72573  2.61342   4.02772   1.000 6.49389  ? 146 GLY   A O   1 
ATOM   1134 N N   . ILE   A 1 168 ? -7.01163  1.16171   2.88841   1.000 5.49464  ? 147 ILE   A N   1 
ATOM   1135 C CA  . ILE   A 1 168 ? -6.96599  1.95838   1.66442   1.000 6.65691  ? 147 ILE   A CA  1 
ATOM   1136 C C   . ILE   A 1 168 ? -7.58085  3.33379   1.89788   1.000 8.37609  ? 147 ILE   A C   1 
ATOM   1137 O O   . ILE   A 1 168 ? -7.02837  4.35652   1.47180   1.000 4.71146  ? 147 ILE   A O   1 
ATOM   1138 C CB  . ILE   A 1 168 ? -7.66213  1.20826   0.51167   1.000 6.29330  ? 147 ILE   A CB  1 
ATOM   1139 C CG1 . ILE   A 1 168 ? -6.81639  0.01042   0.06529   1.000 10.33169 ? 147 ILE   A CG1 1 
ATOM   1140 C CG2 . ILE   A 1 168 ? -7.94161  2.14566   -0.66034  1.000 11.77396 ? 147 ILE   A CG2 1 
ATOM   1141 C CD1 . ILE   A 1 168 ? -7.45493  -0.81953  -1.04119  1.000 5.31295  ? 147 ILE   A CD1 1 
ATOM   1142 N N   . SER   A 1 169 ? -8.72246  3.38449   2.59335   1.000 4.18902  ? 148 SER   A N   1 
ATOM   1143 C CA  . SER   A 1 169 ? -9.36373  4.66784   2.87207   1.000 8.62809  ? 148 SER   A CA  1 
ATOM   1144 C C   . SER   A 1 169 ? -8.48458  5.56277   3.73609   1.000 6.18347  ? 148 SER   A C   1 
ATOM   1145 O O   . SER   A 1 169 ? -8.37967  6.76933   3.48435   1.000 7.18445  ? 148 SER   A O   1 
ATOM   1146 C CB  . SER   A 1 169 ? -10.71273 4.45679   3.55822   1.000 7.17131  ? 148 SER   A CB  1 
ATOM   1147 O OG  . SER   A 1 169 ? -11.61361 3.73176   2.74159   1.000 13.92412 ? 148 SER   A OG  1 
ATOM   1148 N N   . ARG   A 1 170 ? -7.87099  5.00270   4.78068   1.000 9.50921  ? 149 ARG   A N   1 
ATOM   1149 C CA  . ARG   A 1 170 ? -7.09512  5.84083   5.68827   1.000 8.01899  ? 149 ARG   A CA  1 
ATOM   1150 C C   . ARG   A 1 170 ? -5.83466  6.36517   5.01460   1.000 8.13604  ? 149 ARG   A C   1 
ATOM   1151 O O   . ARG   A 1 170 ? -5.45596  7.52439   5.21725   1.000 10.15458 ? 149 ARG   A O   1 
ATOM   1152 C CB  . ARG   A 1 170 ? -6.75850  5.07515   6.96893   1.000 8.33570  ? 149 ARG   A CB  1 
ATOM   1153 C CG  . ARG   A 1 170 ? -7.95426  4.36698   7.60874   1.000 12.53206 ? 149 ARG   A CG  1 
ATOM   1154 C CD  . ARG   A 1 170 ? -8.87665  5.31680   8.37353   1.000 14.03084 ? 149 ARG   A CD  1 
ATOM   1155 N NE  . ARG   A 1 170 ? -9.61981  6.24111   7.52023   1.000 9.79714  ? 149 ARG   A NE  1 
ATOM   1156 C CZ  . ARG   A 1 170 ? -10.79297 5.97397   6.96099   1.000 18.66547 ? 149 ARG   A CZ  1 
ATOM   1157 N NH1 . ARG   A 1 170 ? -11.37505 4.79267   7.10195   1.000 16.86488 ? 149 ARG   A NH1 1 
ATOM   1158 N NH2 . ARG   A 1 170 ? -11.40102 6.91740   6.24579   1.000 14.59420 ? 149 ARG   A NH2 1 
ATOM   1159 N N   . VAL   A 1 171 ? -5.17693  5.53327   4.20447   1.000 7.76251  ? 150 VAL   A N   1 
ATOM   1160 C CA  . VAL   A 1 171 ? -4.01468  6.00243   3.45476   1.000 8.32072  ? 150 VAL   A CA  1 
ATOM   1161 C C   . VAL   A 1 171 ? -4.42745  7.07364   2.45360   1.000 8.66474  ? 150 VAL   A C   1 
ATOM   1162 O O   . VAL   A 1 171 ? -3.73747  8.08742   2.28686   1.000 8.20456  ? 150 VAL   A O   1 
ATOM   1163 C CB  . VAL   A 1 171 ? -3.30584  4.82206   2.76642   1.000 6.52301  ? 150 VAL   A CB  1 
ATOM   1164 C CG1 . VAL   A 1 171 ? -2.19457  5.32334   1.86034   1.000 6.66413  ? 150 VAL   A CG1 1 
ATOM   1165 C CG2 . VAL   A 1 171 ? -2.75442  3.86663   3.80791   1.000 8.56761  ? 150 VAL   A CG2 1 
ATOM   1166 N N   . ALA   A 1 172 ? -5.56690  6.87554   1.78454   1.000 6.40787  ? 151 ALA   A N   1 
ATOM   1167 C CA  . ALA   A 1 172 ? -6.04991  7.87390   0.83545   1.000 10.78161 ? 151 ALA   A CA  1 
ATOM   1168 C C   . ALA   A 1 172 ? -6.27250  9.22033   1.51342   1.000 12.11423 ? 151 ALA   A C   1 
ATOM   1169 O O   . ALA   A 1 172 ? -5.91819  10.26777  0.95905   1.000 9.81282  ? 151 ALA   A O   1 
ATOM   1170 C CB  . ALA   A 1 172 ? -7.33949  7.39017   0.17045   1.000 8.95001  ? 151 ALA   A CB  1 
ATOM   1171 N N   . ASP   A 1 173 ? -6.85040  9.21447   2.71878   1.000 10.90220 ? 152 ASP   A N   1 
ATOM   1172 C CA  . ASP   A 1 173 ? -7.07851  10.46980  3.42798   1.000 9.80657  ? 152 ASP   A CA  1 
ATOM   1173 C C   . ASP   A 1 173 ? -5.76187  11.14982  3.78495   1.000 12.59500 ? 152 ASP   A C   1 
ATOM   1174 O O   . ASP   A 1 173 ? -5.65288  12.38007  3.71372   1.000 14.39461 ? 152 ASP   A O   1 
ATOM   1175 C CB  . ASP   A 1 173 ? -7.91473  10.22630  4.68321   1.000 9.56496  ? 152 ASP   A CB  1 
ATOM   1176 C CG  . ASP   A 1 173 ? -9.38430  10.01023  4.37117   1.000 14.99745 ? 152 ASP   A CG  1 
ATOM   1177 O OD1 . ASP   A 1 173 ? -9.77406  10.14577  3.19008   1.000 13.51376 ? 152 ASP   A OD1 1 
ATOM   1178 O OD2 . ASP   A 1 173 ? -10.15227 9.72009   5.31066   1.000 15.18227 ? 152 ASP   A OD2 1 
ATOM   1179 N N   . TYR   A 1 174 ? -4.75397  10.36661  4.18309   1.000 10.00319 ? 153 TYR   A N   1 
ATOM   1180 C CA  . TYR   A 1 174 ? -3.43021  10.92909  4.44314   1.000 10.98778 ? 153 TYR   A CA  1 
ATOM   1181 C C   . TYR   A 1 174 ? -2.83198  11.53332  3.17968   1.000 10.83233 ? 153 TYR   A C   1 
ATOM   1182 O O   . TYR   A 1 174 ? -2.31413  12.65611  3.19724   1.000 10.90754 ? 153 TYR   A O   1 
ATOM   1183 C CB  . TYR   A 1 174 ? -2.49679  9.85364   5.00996   1.000 10.25209 ? 153 TYR   A CB  1 
ATOM   1184 C CG  . TYR   A 1 174 ? -1.04337  10.28838  5.11009   1.000 13.82562 ? 153 TYR   A CG  1 
ATOM   1185 C CD1 . TYR   A 1 174 ? -0.15858  10.09992  4.05052   1.000 10.64624 ? 153 TYR   A CD1 1 
ATOM   1186 C CD2 . TYR   A 1 174 ? -0.56026  10.89798  6.26080   1.000 12.67352 ? 153 TYR   A CD2 1 
ATOM   1187 C CE1 . TYR   A 1 174 ? 1.16212   10.50333  4.13935   1.000 10.69525 ? 153 TYR   A CE1 1 
ATOM   1188 C CE2 . TYR   A 1 174 ? 0.76027   11.29924  6.35879   1.000 14.45045 ? 153 TYR   A CE2 1 
ATOM   1189 C CZ  . TYR   A 1 174 ? 1.61392   11.10353  5.29510   1.000 16.00813 ? 153 TYR   A CZ  1 
ATOM   1190 O OH  . TYR   A 1 174 ? 2.92581   11.50607  5.39093   1.000 22.23346 ? 153 TYR   A OH  1 
ATOM   1191 N N   . LEU   A 1 175 ? -2.88638  10.79691  2.07037   1.000 8.93817  ? 154 LEU   A N   1 
ATOM   1192 C CA  . LEU   A 1 175 ? -2.27680  11.27627  0.83653   1.000 11.49676 ? 154 LEU   A CA  1 
ATOM   1193 C C   . LEU   A 1 175 ? -3.00061  12.48210  0.25711   1.000 19.51570 ? 154 LEU   A C   1 
ATOM   1194 O O   . LEU   A 1 175 ? -2.45282  13.14566  -0.63121  1.000 18.34733 ? 154 LEU   A O   1 
ATOM   1195 C CB  . LEU   A 1 175 ? -2.21638  10.14724  -0.19298  1.000 8.43395  ? 154 LEU   A CB  1 
ATOM   1196 C CG  . LEU   A 1 175 ? -1.18117  9.06456   0.13498   1.000 10.15809 ? 154 LEU   A CG  1 
ATOM   1197 C CD1 . LEU   A 1 175 ? -1.26991  7.89224   -0.82964  1.000 11.00566 ? 154 LEU   A CD1 1 
ATOM   1198 C CD2 . LEU   A 1 175 ? 0.22704   9.64936   0.15372   1.000 10.61369 ? 154 LEU   A CD2 1 
ATOM   1199 N N   . LYS   A 1 176 ? -4.20754  12.78496  0.73909   1.000 15.39430 ? 155 LYS   A N   1 
ATOM   1200 C CA  . LYS   A 1 176 ? -4.87171  14.01496  0.32866   1.000 22.97573 ? 155 LYS   A CA  1 
ATOM   1201 C C   . LYS   A 1 176 ? -4.11934  15.23945  0.83299   1.000 17.24692 ? 155 LYS   A C   1 
ATOM   1202 O O   . LYS   A 1 176 ? -4.13225  16.28752  0.17745   1.000 17.03714 ? 155 LYS   A O   1 
ATOM   1203 C CB  . LYS   A 1 176 ? -6.32083  14.01126  0.82068   1.000 17.32335 ? 155 LYS   A CB  1 
ATOM   1204 C CG  . LYS   A 1 176 ? -7.24291  13.21296  -0.09400  1.000 23.84724 ? 155 LYS   A CG  1 
ATOM   1205 C CD  . LYS   A 1 176 ? -8.59020  12.85919  0.52922   1.000 27.84834 ? 155 LYS   A CD  1 
ATOM   1206 C CE  . LYS   A 1 176 ? -8.99231  13.79059  1.65479   1.000 23.63512 ? 155 LYS   A CE  1 
ATOM   1207 N NZ  . LYS   A 1 176 ? -10.47255 13.75337  1.85529   1.000 33.46335 ? 155 LYS   A NZ  1 
ATOM   1208 N N   . ALA   A 1 177 ? -3.45607  15.12419  1.98432   1.000 18.53358 ? 156 ALA   A N   1 
ATOM   1209 C CA  . ALA   A 1 177 ? -2.62450  16.19216  2.52290   1.000 19.34241 ? 156 ALA   A CA  1 
ATOM   1210 C C   . ALA   A 1 177 ? -1.18114  16.13233  2.04228   1.000 18.55722 ? 156 ALA   A C   1 
ATOM   1211 O O   . ALA   A 1 177 ? -0.44054  17.10031  2.24181   1.000 19.58574 ? 156 ALA   A O   1 
ATOM   1212 C CB  . ALA   A 1 177 ? -2.63741  16.15487  4.05430   1.000 20.39819 ? 156 ALA   A CB  1 
ATOM   1213 N N   . HIS   A 1 178 ? -0.75975  15.03206  1.42294   1.000 12.62302 ? 157 HIS   A N   1 
ATOM   1214 C CA  . HIS   A 1 178 ? 0.63257   14.83290  1.01816   1.000 15.91983 ? 157 HIS   A CA  1 
ATOM   1215 C C   . HIS   A 1 178 ? 0.67887   14.39667  -0.44096  1.000 17.33811 ? 157 HIS   A C   1 
ATOM   1216 O O   . HIS   A 1 178 ? 0.99498   13.24140  -0.75177  1.000 15.49881 ? 157 HIS   A O   1 
ATOM   1217 C CB  . HIS   A 1 178 ? 1.31728   13.81485  1.93071   1.000 15.04378 ? 157 HIS   A CB  1 
ATOM   1218 C CG  . HIS   A 1 178 ? 1.22502   14.15863  3.38507   1.000 17.45224 ? 157 HIS   A CG  1 
ATOM   1219 N ND1 . HIS   A 1 178 ? 0.05893   14.02989  4.10878   1.000 18.60621 ? 157 HIS   A ND1 1 
ATOM   1220 C CD2 . HIS   A 1 178 ? 2.15185   14.63701  4.24860   1.000 19.58182 ? 157 HIS   A CD2 1 
ATOM   1221 C CE1 . HIS   A 1 178 ? 0.27125   14.41380  5.35494   1.000 18.61867 ? 157 HIS   A CE1 1 
ATOM   1222 N NE2 . HIS   A 1 178 ? 1.53357   14.78557  5.46655   1.000 23.21132 ? 157 HIS   A NE2 1 
ATOM   1223 N N   . PRO   A 1 179 ? 0.37457   15.31014  -1.36752  1.000 20.50798 ? 158 PRO   A N   1 
ATOM   1224 C CA  . PRO   A 1 179 ? 0.30075   14.92576  -2.78727  1.000 23.22530 ? 158 PRO   A CA  1 
ATOM   1225 C C   . PRO   A 1 179 ? 1.62008   14.45269  -3.37429  1.000 18.21144 ? 158 PRO   A C   1 
ATOM   1226 O O   . PRO   A 1 179 ? 1.61090   13.75743  -4.39633  1.000 19.05716 ? 158 PRO   A O   1 
ATOM   1227 C CB  . PRO   A 1 179 ? -0.18385  16.21214  -3.47084  1.000 23.30086 ? 158 PRO   A CB  1 
ATOM   1228 C CG  . PRO   A 1 179 ? 0.21646   17.30589  -2.53782  1.000 23.80822 ? 158 PRO   A CG  1 
ATOM   1229 C CD  . PRO   A 1 179 ? 0.03658   16.72924  -1.16689  1.000 24.90184 ? 158 PRO   A CD  1 
ATOM   1230 N N   . LYS   A 1 180 ? 2.75301   14.80760  -2.77550  1.000 22.57060 ? 159 LYS   A N   1 
ATOM   1231 C CA  . LYS   A 1 180 ? 4.04872   14.42392  -3.31599  1.000 22.14385 ? 159 LYS   A CA  1 
ATOM   1232 C C   . LYS   A 1 180 ? 4.51225   13.04947  -2.85351  1.000 18.21642 ? 159 LYS   A C   1 
ATOM   1233 O O   . LYS   A 1 180 ? 5.47946   12.52151  -3.41046  1.000 16.22903 ? 159 LYS   A O   1 
ATOM   1234 C CB  . LYS   A 1 180 ? 5.10607   15.46155  -2.92455  1.000 24.01835 ? 159 LYS   A CB  1 
ATOM   1235 C CG  . LYS   A 1 180 ? 5.06972   16.73627  -3.74685  1.000 23.87393 ? 159 LYS   A CG  1 
ATOM   1236 C CD  . LYS   A 1 180 ? 6.37499   17.49909  -3.61172  1.000 35.30250 ? 159 LYS   A CD  1 
ATOM   1237 C CE  . LYS   A 1 180 ? 6.26059   18.59154  -2.55726  1.000 41.62583 ? 159 LYS   A CE  1 
ATOM   1238 N NZ  . LYS   A 1 180 ? 5.72553   19.86515  -3.11743  1.000 49.12376 ? 159 LYS   A NZ  1 
ATOM   1239 N N   . GLU   A 1 181 ? 3.84732   12.45186  -1.87326  1.000 14.83807 ? 160 GLU   A N   1 
ATOM   1240 C CA  . GLU   A 1 181 ? 4.40475   11.31810  -1.15534  1.000 11.61669 ? 160 GLU   A CA  1 
ATOM   1241 C C   . GLU   A 1 181 ? 3.85827   9.99209   -1.67357  1.000 13.36549 ? 160 GLU   A C   1 
ATOM   1242 O O   . GLU   A 1 181 ? 2.85862   9.93206   -2.39479  1.000 14.98777 ? 160 GLU   A O   1 
ATOM   1243 C CB  . GLU   A 1 181 ? 4.12912   11.45189  0.34406   1.000 11.87274 ? 160 GLU   A CB  1 
ATOM   1244 C CG  . GLU   A 1 181 ? 4.81214   12.65243  0.97924   1.000 13.07909 ? 160 GLU   A CG  1 
ATOM   1245 C CD  . GLU   A 1 181 ? 4.60393   12.72334  2.48134   1.000 16.30478 ? 160 GLU   A CD  1 
ATOM   1246 O OE1 . GLU   A 1 181 ? 3.88834   11.85492  3.02856   1.000 13.34932 ? 160 GLU   A OE1 1 
ATOM   1247 O OE2 . GLU   A 1 181 ? 5.15517   13.65035  3.11295   1.000 17.52764 ? 160 GLU   A OE2 1 
ATOM   1248 N N   . ALA   A 1 182 ? 4.55077   8.92202   -1.29556  1.000 12.31112 ? 161 ALA   A N   1 
ATOM   1249 C CA  . ALA   A 1 182 ? 4.16450   7.55403   -1.60094  1.000 9.40915  ? 161 ALA   A CA  1 
ATOM   1250 C C   . ALA   A 1 182 ? 3.98665   6.78791   -0.29954  1.000 11.71290 ? 161 ALA   A C   1 
ATOM   1251 O O   . ALA   A 1 182 ? 4.72591   7.00674   0.66704   1.000 9.20207  ? 161 ALA   A O   1 
ATOM   1252 C CB  . ALA   A 1 182 ? 5.21105   6.85967   -2.47737  1.000 11.71191 ? 161 ALA   A CB  1 
ATOM   1253 N N   . ALA   A 1 183 ? 3.00429   5.89136   -0.27777  1.000 11.93369 ? 162 ALA   A N   1 
ATOM   1254 C CA  . ALA   A 1 183 ? 2.68590   5.12703   0.91753   1.000 8.79840  ? 162 ALA   A CA  1 
ATOM   1255 C C   . ALA   A 1 183 ? 2.46475   3.66819   0.54884   1.000 8.28204  ? 162 ALA   A C   1 
ATOM   1256 O O   . ALA   A 1 183 ? 2.04636   3.34817   -0.56720  1.000 9.25873  ? 162 ALA   A O   1 
ATOM   1257 C CB  . ALA   A 1 183 ? 1.44599   5.68670   1.62581   1.000 8.90501  ? 162 ALA   A CB  1 
ATOM   1258 N N   . ILE   A 1 184 ? 2.76371   2.78378   1.49648   1.000 7.97485  ? 163 ILE   A N   1 
ATOM   1259 C CA  . ILE   A 1 184 ? 2.51935   1.35400   1.35389   1.000 8.38768  ? 163 ILE   A CA  1 
ATOM   1260 C C   . ILE   A 1 184 ? 1.55803   0.91607   2.44742   1.000 6.01192  ? 163 ILE   A C   1 
ATOM   1261 O O   . ILE   A 1 184 ? 1.74115   1.26326   3.61991   1.000 7.36076  ? 163 ILE   A O   1 
ATOM   1262 C CB  . ILE   A 1 184 ? 3.82032   0.53327   1.41972   1.000 8.25698  ? 163 ILE   A CB  1 
ATOM   1263 C CG1 . ILE   A 1 184 ? 4.65637   0.74743   0.15668   1.000 7.78840  ? 163 ILE   A CG1 1 
ATOM   1264 C CG2 . ILE   A 1 184 ? 3.51454   -0.94477  1.62063   1.000 9.50667  ? 163 ILE   A CG2 1 
ATOM   1265 C CD1 . ILE   A 1 184 ? 6.02454   0.09824   0.22110   1.000 9.12117  ? 163 ILE   A CD1 1 
ATOM   1266 N N   . LEU   A 1 185 ? 0.52735   0.17488   2.05857   1.000 9.45256  ? 164 LEU   A N   1 
ATOM   1267 C CA  . LEU   A 1 185 ? -0.35263  -0.50883  2.99112   1.000 9.27730  ? 164 LEU   A CA  1 
ATOM   1268 C C   . LEU   A 1 185 ? -0.17365  -2.00853  2.81156   1.000 8.71060  ? 164 LEU   A C   1 
ATOM   1269 O O   . LEU   A 1 185 ? -0.04332  -2.49120  1.68402   1.000 5.97548  ? 164 LEU   A O   1 
ATOM   1270 C CB  . LEU   A 1 185 ? -1.81651  -0.12252  2.75824   1.000 6.18021  ? 164 LEU   A CB  1 
ATOM   1271 C CG  . LEU   A 1 185 ? -2.87954  -1.03276  3.37266   1.000 7.22834  ? 164 LEU   A CG  1 
ATOM   1272 C CD1 . LEU   A 1 185 ? -2.99256  -0.78026  4.86906   1.000 7.14952  ? 164 LEU   A CD1 1 
ATOM   1273 C CD2 . LEU   A 1 185 ? -4.23125  -0.84594  2.68477   1.000 7.25754  ? 164 LEU   A CD2 1 
ATOM   1274 N N   . PHE   A 1 186 ? -0.13553  -2.74546  3.91578   1.000 3.83626  ? 165 PHE   A N   1 
ATOM   1275 C CA  . PHE   A 1 186 ? -0.17262  -4.19534  3.83610   1.000 8.24213  ? 165 PHE   A CA  1 
ATOM   1276 C C   . PHE   A 1 186 ? -1.15391  -4.73748  4.86267   1.000 6.49083  ? 165 PHE   A C   1 
ATOM   1277 O O   . PHE   A 1 186 ? -1.36329  -4.14659  5.92650   1.000 7.05651  ? 165 PHE   A O   1 
ATOM   1278 C CB  . PHE   A 1 186 ? 1.21815   -4.83697  4.02560   1.000 7.06803  ? 165 PHE   A CB  1 
ATOM   1279 C CG  . PHE   A 1 186 ? 1.77334   -4.72574  5.42000   1.000 6.03506  ? 165 PHE   A CG  1 
ATOM   1280 C CD1 . PHE   A 1 186 ? 2.51436   -3.62062  5.80413   1.000 7.27895  ? 165 PHE   A CD1 1 
ATOM   1281 C CD2 . PHE   A 1 186 ? 1.59026   -5.75322  6.33116   1.000 6.29152  ? 165 PHE   A CD2 1 
ATOM   1282 C CE1 . PHE   A 1 186 ? 3.03998   -3.53276  7.08323   1.000 10.03082 ? 165 PHE   A CE1 1 
ATOM   1283 C CE2 . PHE   A 1 186 ? 2.10775   -5.67136  7.60653   1.000 5.89760  ? 165 PHE   A CE2 1 
ATOM   1284 C CZ  . PHE   A 1 186 ? 2.83847   -4.56402  7.98370   1.000 6.89975  ? 165 PHE   A CZ  1 
ATOM   1285 N N   . ALA   A 1 187 ? -1.77466  -5.85740  4.50326   1.000 4.57885  ? 166 ALA   A N   1 
ATOM   1286 C CA  . ALA   A 1 187 ? -2.69224  -6.59301  5.35822   1.000 7.83319  ? 166 ALA   A CA  1 
ATOM   1287 C C   . ALA   A 1 187 ? -2.22032  -8.03453  5.42274   1.000 8.30185  ? 166 ALA   A C   1 
ATOM   1288 O O   . ALA   A 1 187 ? -1.92283  -8.63410  4.38535   1.000 7.29304  ? 166 ALA   A O   1 
ATOM   1289 C CB  . ALA   A 1 187 ? -4.12449  -6.53399  4.81863   1.000 7.77054  ? 166 ALA   A CB  1 
ATOM   1290 N N   . VAL   A 1 188 ? -2.14951  -8.58856  6.62894   1.000 5.37543  ? 167 VAL   A N   1 
ATOM   1291 C CA  . VAL   A 1 188 ? -1.70452  -9.96686  6.80784   1.000 8.64239  ? 167 VAL   A CA  1 
ATOM   1292 C C   . VAL   A 1 188 ? -2.45784  -10.56074 7.98804   1.000 9.75279  ? 167 VAL   A C   1 
ATOM   1293 O O   . VAL   A 1 188 ? -2.58440  -9.92357  9.03757   1.000 9.54753  ? 167 VAL   A O   1 
ATOM   1294 C CB  . VAL   A 1 188 ? -0.17596  -10.05250 7.01474   1.000 6.08771  ? 167 VAL   A CB  1 
ATOM   1295 C CG1 . VAL   A 1 188 ? 0.27872   -9.09369  8.11039   1.000 8.78244  ? 167 VAL   A CG1 1 
ATOM   1296 C CG2 . VAL   A 1 188 ? 0.24286   -11.47737 7.32390   1.000 4.28754  ? 167 VAL   A CG2 1 
ATOM   1297 N N   . GLU   A 1 189 ? -2.99067  -11.76864 7.80881   1.000 8.04532  ? 168 GLU   A N   1 
ATOM   1298 C CA  . GLU   A 1 189 ? -3.67001  -12.46578 8.89039   1.000 6.24889  ? 168 GLU   A CA  1 
ATOM   1299 C C   . GLU   A 1 189 ? -3.25342  -13.92604 8.90866   1.000 9.52392  ? 168 GLU   A C   1 
ATOM   1300 O O   . GLU   A 1 189 ? -3.09264  -14.54847 7.85548   1.000 9.35500  ? 168 GLU   A O   1 
ATOM   1301 C CB  . GLU   A 1 189 ? -5.20072  -12.35794 8.77321   1.000 7.38452  ? 168 GLU   A CB  1 
ATOM   1302 C CG  . GLU   A 1 189 ? -5.71401  -10.94942 8.49900   1.000 10.74109 ? 168 GLU   A CG  1 
ATOM   1303 C CD  . GLU   A 1 189 ? -5.64977  -10.05726 9.72982   1.000 9.59084  ? 168 GLU   A CD  1 
ATOM   1304 O OE1 . GLU   A 1 189 ? -5.29305  -10.56192 10.81521  1.000 6.81626  ? 168 GLU   A OE1 1 
ATOM   1305 O OE2 . GLU   A 1 189 ? -5.95860  -8.85290  9.61206   1.000 9.12713  ? 168 GLU   A OE2 1 
ATOM   1306 N N   . ILE   A 1 190 ? -3.08317  -14.46659 10.11407  1.000 9.10259  ? 169 ILE   A N   1 
ATOM   1307 C CA  . ILE   A 1 190 ? -2.79187  -15.88463 10.28381  1.000 14.11762 ? 169 ILE   A CA  1 
ATOM   1308 C C   . ILE   A 1 190 ? -4.00380  -16.55404 10.91676  1.000 13.96025 ? 169 ILE   A C   1 
ATOM   1309 O O   . ILE   A 1 190 ? -4.06928  -16.71971 12.13980  1.000 12.62833 ? 169 ILE   A O   1 
ATOM   1310 C CB  . ILE   A 1 190 ? -1.53326  -16.09816 11.14630  1.000 13.96364 ? 169 ILE   A CB  1 
ATOM   1311 C CG1 . ILE   A 1 190 ? -0.40255  -15.16889 10.69963  1.000 11.07533 ? 169 ILE   A CG1 1 
ATOM   1312 C CG2 . ILE   A 1 190 ? -1.08337  -17.55065 11.09335  1.000 13.79195 ? 169 ILE   A CG2 1 
ATOM   1313 C CD1 . ILE   A 1 190 ? 0.12117   -15.46156 9.30916   1.000 13.85668 ? 169 ILE   A CD1 1 
ATOM   1314 N N   . SER   A 1 191 ? -4.95835  -16.97661 10.08576  1.000 13.18701 ? 170 SER   A N   1 
ATOM   1315 C CA  . SER   A 1 191 ? -6.14868  -17.63343 10.60943  1.000 11.86817 ? 170 SER   A CA  1 
ATOM   1316 C C   . SER   A 1 191 ? -5.83155  -19.00915 11.17303  1.000 10.39391 ? 170 SER   A C   1 
ATOM   1317 O O   . SER   A 1 191 ? -6.54893  -19.48748 12.05981  1.000 12.67514 ? 170 SER   A O   1 
ATOM   1318 C CB  . SER   A 1 191 ? -7.21453  -17.75162 9.52077   1.000 11.27651 ? 170 SER   A CB  1 
ATOM   1319 O OG  . SER   A 1 191 ? -7.54151  -16.48085 8.98326   1.000 10.22963 ? 170 SER   A OG  1 
ATOM   1320 N N   . SER   A 1 192 ? -4.75949  -19.64510 10.69719  1.000 9.65123  ? 171 SER   A N   1 
ATOM   1321 C CA  . SER   A 1 192 ? -4.39861  -20.96536 11.19467  1.000 14.90355 ? 171 SER   A CA  1 
ATOM   1322 C C   . SER   A 1 192 ? -3.96606  -20.93764 12.65454  1.000 12.79553 ? 171 SER   A C   1 
ATOM   1323 O O   . SER   A 1 192 ? -3.80890  -22.00655 13.25234  1.000 18.62233 ? 171 SER   A O   1 
ATOM   1324 C CB  . SER   A 1 192 ? -3.29992  -21.57662 10.31985  1.000 12.25926 ? 171 SER   A CB  1 
ATOM   1325 O OG  . SER   A 1 192 ? -2.14174  -20.76207 10.27756  1.000 12.07929 ? 171 SER   A OG  1 
ATOM   1326 N N   . ALA   A 1 193 ? -3.76903  -19.74921 13.23662  1.000 12.35391 ? 172 ALA   A N   1 
ATOM   1327 C CA  . ALA   A 1 193 ? -3.50919  -19.65603 14.67091  1.000 16.48021 ? 172 ALA   A CA  1 
ATOM   1328 C C   . ALA   A 1 193 ? -4.63706  -20.27510 15.48624  1.000 15.97128 ? 172 ALA   A C   1 
ATOM   1329 O O   . ALA   A 1 193 ? -4.39491  -20.81194 16.57340  1.000 17.51256 ? 172 ALA   A O   1 
ATOM   1330 C CB  . ALA   A 1 193 ? -3.30240  -18.19481 15.07366  1.000 12.13452 ? 172 ALA   A CB  1 
ATOM   1331 N N   . LEU   A 1 194 ? -5.87209  -20.21500 14.97913  1.000 13.46687 ? 173 LEU   A N   1 
ATOM   1332 C CA  . LEU   A 1 194 ? -7.00478  -20.80781 15.67933  1.000 15.88591 ? 173 LEU   A CA  1 
ATOM   1333 C C   . LEU   A 1 194 ? -6.96611  -22.32927 15.66070  1.000 15.15749 ? 173 LEU   A C   1 
ATOM   1334 O O   . LEU   A 1 194 ? -7.66424  -22.96481 16.45814  1.000 18.21042 ? 173 LEU   A O   1 
ATOM   1335 C CB  . LEU   A 1 194 ? -8.31808  -20.31153 15.07034  1.000 14.41925 ? 173 LEU   A CB  1 
ATOM   1336 C CG  . LEU   A 1 194 ? -8.86951  -18.98084 15.59482  1.000 24.63587 ? 173 LEU   A CG  1 
ATOM   1337 C CD1 . LEU   A 1 194 ? -7.96867  -17.80410 15.24491  1.000 29.40490 ? 173 LEU   A CD1 1 
ATOM   1338 C CD2 . LEU   A 1 194 ? -10.27449 -18.74835 15.06225  1.000 21.62573 ? 173 LEU   A CD2 1 
ATOM   1339 N N   . TRP   A 1 195 ? -6.17859  -22.92307 14.77004  1.000 12.90324 ? 174 TRP   A N   1 
ATOM   1340 C CA  . TRP   A 1 195 ? -6.01395  -24.36754 14.71528  1.000 14.89063 ? 174 TRP   A CA  1 
ATOM   1341 C C   . TRP   A 1 195 ? -4.90339  -24.86489 15.62852  1.000 23.80526 ? 174 TRP   A C   1 
ATOM   1342 O O   . TRP   A 1 195 ? -4.62758  -26.06857 15.64596  1.000 28.17998 ? 174 TRP   A O   1 
ATOM   1343 C CB  . TRP   A 1 195 ? -5.72844  -24.81313 13.27912  1.000 16.25360 ? 174 TRP   A CB  1 
ATOM   1344 C CG  . TRP   A 1 195 ? -6.91979  -24.73767 12.38253  1.000 16.67801 ? 174 TRP   A CG  1 
ATOM   1345 C CD1 . TRP   A 1 195 ? -7.62290  -23.61830 12.04361  1.000 17.65058 ? 174 TRP   A CD1 1 
ATOM   1346 C CD2 . TRP   A 1 195 ? -7.56036  -25.83097 11.71936  1.000 18.77706 ? 174 TRP   A CD2 1 
ATOM   1347 N NE1 . TRP   A 1 195 ? -8.65781  -23.94617 11.20335  1.000 19.01851 ? 174 TRP   A NE1 1 
ATOM   1348 C CE2 . TRP   A 1 195 ? -8.64186  -25.29959 10.98794  1.000 21.19204 ? 174 TRP   A CE2 1 
ATOM   1349 C CE3 . TRP   A 1 195 ? -7.32148  -27.20748 11.66766  1.000 19.60485 ? 174 TRP   A CE3 1 
ATOM   1350 C CZ2 . TRP   A 1 195 ? -9.48414  -26.09721 10.21437  1.000 19.56682 ? 174 TRP   A CZ2 1 
ATOM   1351 C CZ3 . TRP   A 1 195 ? -8.15807  -27.99772 10.89990  1.000 25.24745 ? 174 TRP   A CZ3 1 
ATOM   1352 C CH2 . TRP   A 1 195 ? -9.22661  -27.44055 10.18337  1.000 19.27108 ? 174 TRP   A CH2 1 
ATOM   1353 N N   . GLN   A 1 196 ? -4.25327  -23.97109 16.37319  1.000 19.51028 ? 175 GLN   A N   1 
ATOM   1354 C CA  . GLN   A 1 196 ? -3.18111  -24.33973 17.28462  1.000 22.08482 ? 175 GLN   A CA  1 
ATOM   1355 C C   . GLN   A 1 196 ? -3.67227  -24.56630 18.71007  1.000 26.34457 ? 175 GLN   A C   1 
ATOM   1356 O O   . GLN   A 1 196 ? -2.86456  -24.53286 19.64556  1.000 28.68113 ? 175 GLN   A O   1 
ATOM   1357 C CB  . GLN   A 1 196 ? -2.08426  -23.27170 17.26990  1.000 24.94179 ? 175 GLN   A CB  1 
ATOM   1358 C CG  . GLN   A 1 196 ? -1.62157  -22.86516 15.87851  1.000 20.70859 ? 175 GLN   A CG  1 
ATOM   1359 C CD  . GLN   A 1 196 ? -1.09072  -24.03567 15.07220  1.000 28.18288 ? 175 GLN   A CD  1 
ATOM   1360 O OE1 . GLN   A 1 196 ? -0.15548  -24.72057 15.49125  1.000 29.02903 ? 175 GLN   A OE1 1 
ATOM   1361 N NE2 . GLN   A 1 196 ? -1.68957  -24.27479 13.91006  1.000 22.66385 ? 175 GLN   A NE2 1 
ATOM   1362 N N   . GLY   A 1 197 ? -4.97028  -24.79874 18.89618  1.000 26.59122 ? 176 GLY   A N   1 
ATOM   1363 C CA  . GLY   A 1 197 ? -5.49805  -25.09752 20.21294  1.000 24.06114 ? 176 GLY   A CA  1 
ATOM   1364 C C   . GLY   A 1 197 ? -6.85515  -24.49330 20.51066  1.000 23.86075 ? 176 GLY   A C   1 
ATOM   1365 O O   . GLY   A 1 197 ? -7.64350  -25.08145 21.25648  1.000 28.34320 ? 176 GLY   A O   1 
ATOM   1366 N N   . SER   A 1 198 ? -7.14732  -23.32654 19.92965  1.000 22.68910 ? 177 SER   A N   1 
ATOM   1367 C CA  . SER   A 1 198 ? -8.37453  -22.61310 20.27362  1.000 21.02222 ? 177 SER   A CA  1 
ATOM   1368 C C   . SER   A 1 198 ? -9.61314  -23.37619 19.81831  1.000 23.91904 ? 177 SER   A C   1 
ATOM   1369 O O   . SER   A 1 198 ? -10.54713 -23.58692 20.60160  1.000 25.24178 ? 177 SER   A O   1 
ATOM   1370 C CB  . SER   A 1 198 ? -8.35325  -21.21245 19.66225  1.000 18.21787 ? 177 SER   A CB  1 
ATOM   1371 O OG  . SER   A 1 198 ? -7.31365  -20.42951 20.22210  1.000 23.72364 ? 177 SER   A OG  1 
ATOM   1372 N N   . LEU   A 1 199 ? -9.64498  -23.79045 18.54977  1.000 19.29525 ? 178 LEU   A N   1 
ATOM   1373 C CA  . LEU   A 1 199 ? -10.79648 -24.53586 18.05137  1.000 19.38459 ? 178 LEU   A CA  1 
ATOM   1374 C C   . LEU   A 1 199 ? -10.88848 -25.90614 18.70834  1.000 18.75015 ? 178 LEU   A C   1 
ATOM   1375 O O   . LEU   A 1 199 ? -11.98905 -26.39677 18.98235  1.000 24.59654 ? 178 LEU   A O   1 
ATOM   1376 C CB  . LEU   A 1 199 ? -10.72295 -24.67132 16.52942  1.000 20.85650 ? 178 LEU   A CB  1 
ATOM   1377 C CG  . LEU   A 1 199 ? -11.15918 -23.45482 15.71002  1.000 19.92064 ? 178 LEU   A CG  1 
ATOM   1378 C CD1 . LEU   A 1 199 ? -10.66001 -23.56774 14.27589  1.000 16.62134 ? 178 LEU   A CD1 1 
ATOM   1379 C CD2 . LEU   A 1 199 ? -12.67060 -23.29617 15.74084  1.000 18.30882 ? 178 LEU   A CD2 1 
ATOM   1380 N N   . GLN   A 1 200 ? -9.74135  -26.53883 18.96153  1.000 31.70567 ? 179 GLN   A N   1 
ATOM   1381 C CA  . GLN   A 1 200 ? -9.73354  -27.84125 19.61932  1.000 24.37414 ? 179 GLN   A CA  1 
ATOM   1382 C C   . GLN   A 1 200 ? -10.34480 -27.75773 21.01317  1.000 27.09020 ? 179 GLN   A C   1 
ATOM   1383 O O   . GLN   A 1 200 ? -11.20811 -28.56557 21.37589  1.000 28.58256 ? 179 GLN   A O   1 
ATOM   1384 C CB  . GLN   A 1 200 ? -8.30254  -28.37128 19.68760  1.000 22.61001 ? 179 GLN   A CB  1 
ATOM   1385 C CG  . GLN   A 1 200 ? -7.67611  -28.62869 18.33166  1.000 28.45392 ? 179 GLN   A CG  1 
ATOM   1386 C CD  . GLN   A 1 200 ? -6.75201  -27.50959 17.90231  1.000 27.69243 ? 179 GLN   A CD  1 
ATOM   1387 O OE1 . GLN   A 1 200 ? -7.15724  -26.34592 17.84281  1.000 23.52203 ? 179 GLN   A OE1 1 
ATOM   1388 N NE2 . GLN   A 1 200 ? -5.50389  -27.85006 17.60600  1.000 29.64244 ? 179 GLN   A NE2 1 
ATOM   1389 N N   . ALA   A 1 201 ? -9.91473  -26.77362 21.80659  1.000 28.37913 ? 180 ALA   A N   1 
ATOM   1390 C CA  . ALA   A 1 201 ? -10.42022 -26.64600 23.16991  1.000 26.91624 ? 180 ALA   A CA  1 
ATOM   1391 C C   . ALA   A 1 201 ? -11.90134 -26.28577 23.18785  1.000 32.51853 ? 180 ALA   A C   1 
ATOM   1392 O O   . ALA   A 1 201 ? -12.67608 -26.86210 23.96067  1.000 28.73059 ? 180 ALA   A O   1 
ATOM   1393 C CB  . ALA   A 1 201 ? -9.60419  -25.60285 23.93366  1.000 24.32586 ? 180 ALA   A CB  1 
ATOM   1394 N N   . ASN   A 1 202 ? -12.31507 -25.33708 22.34438  1.000 27.94444 ? 181 ASN   A N   1 
ATOM   1395 C CA  . ASN   A 1 202 ? -13.69955 -24.87477 22.37454  1.000 27.47465 ? 181 ASN   A CA  1 
ATOM   1396 C C   . ASN   A 1 202 ? -14.66202 -25.95223 21.89102  1.000 29.31161 ? 181 ASN   A C   1 
ATOM   1397 O O   . ASN   A 1 202 ? -15.70520 -26.18840 22.51193  1.000 38.01157 ? 181 ASN   A O   1 
ATOM   1398 C CB  . ASN   A 1 202 ? -13.85201 -23.60905 21.53487  1.000 30.15906 ? 181 ASN   A CB  1 
ATOM   1399 C CG  . ASN   A 1 202 ? -14.87336 -22.65457 22.11193  1.000 30.99778 ? 181 ASN   A CG  1 
ATOM   1400 O OD1 . ASN   A 1 202 ? -14.88416 -22.38848 23.31373  1.000 28.00001 ? 181 ASN   A OD1 1 
ATOM   1401 N ND2 . ASN   A 1 202 ? -15.75439 -22.14960 21.25969  1.000 26.54563 ? 181 ASN   A ND2 1 
ATOM   1402 N N   . LEU   A 1 203 ? -14.33640 -26.60758 20.77421  1.000 30.59948 ? 182 LEU   A N   1 
ATOM   1403 C CA  . LEU   A 1 203 ? -15.22947 -27.62733 20.23297  1.000 32.99292 ? 182 LEU   A CA  1 
ATOM   1404 C C   . LEU   A 1 203 ? -15.37130 -28.80209 21.19110  1.000 32.05915 ? 182 LEU   A C   1 
ATOM   1405 O O   . LEU   A 1 203 ? -16.46477 -29.35958 21.34173  1.000 30.33826 ? 182 LEU   A O   1 
ATOM   1406 C CB  . LEU   A 1 203 ? -14.72584 -28.10281 18.87106  1.000 31.21781 ? 182 LEU   A CB  1 
ATOM   1407 C CG  . LEU   A 1 203 ? -15.06114 -27.20125 17.68215  1.000 22.62972 ? 182 LEU   A CG  1 
ATOM   1408 C CD1 . LEU   A 1 203 ? -14.34010 -27.68281 16.43408  1.000 26.30544 ? 182 LEU   A CD1 1 
ATOM   1409 C CD2 . LEU   A 1 203 ? -16.56363 -27.14480 17.45467  1.000 25.64350 ? 182 LEU   A CD2 1 
ATOM   1410 N N   . THR   A 1 204 ? -14.27531 -29.19770 21.84178  1.000 30.01287 ? 183 THR   A N   1 
ATOM   1411 C CA  . THR   A 1 204 ? -14.34027 -30.29240 22.80358  1.000 39.23259 ? 183 THR   A CA  1 
ATOM   1412 C C   . THR   A 1 204 ? -15.31562 -29.97040 23.92802  1.000 42.60630 ? 183 THR   A C   1 
ATOM   1413 O O   . THR   A 1 204 ? -16.26885 -30.71629 24.17167  1.000 47.65904 ? 183 THR   A O   1 
ATOM   1414 C CB  . THR   A 1 204 ? -12.94929 -30.58191 23.36951  1.000 35.97559 ? 183 THR   A CB  1 
ATOM   1415 O OG1 . THR   A 1 204 ? -12.04834 -30.88252 22.29807  1.000 31.11598 ? 183 THR   A OG1 1 
ATOM   1416 C CG2 . THR   A 1 204 ? -13.00197 -31.76197 24.32934  1.000 34.79116 ? 183 THR   A CG2 1 
ATOM   1417 N N   . SER   A 1 205 ? -15.11385 -28.83342 24.59945  1.000 37.85543 ? 184 SER   A N   1 
ATOM   1418 C CA  . SER   A 1 205 ? -15.98194 -28.47062 25.71566  1.000 38.51577 ? 184 SER   A CA  1 
ATOM   1419 C C   . SER   A 1 205 ? -17.42320 -28.28635 25.25969  1.000 46.47774 ? 184 SER   A C   1 
ATOM   1420 O O   . SER   A 1 205 ? -18.35953 -28.71779 25.94303  1.000 42.79803 ? 184 SER   A O   1 
ATOM   1421 C CB  . SER   A 1 205 ? -15.46910 -27.19783 26.38789  1.000 41.31803 ? 184 SER   A CB  1 
ATOM   1422 O OG  . SER   A 1 205 ? -16.51077 -26.54543 27.09340  1.000 38.78909 ? 184 SER   A OG  1 
ATOM   1423 N N   . LEU   A 1 206 ? -17.61916 -27.64962 24.10356  1.000 35.77846 ? 185 LEU   A N   1 
ATOM   1424 C CA  . LEU   A 1 206 ? -18.96977 -27.38632 23.61959  1.000 41.12433 ? 185 LEU   A CA  1 
ATOM   1425 C C   . LEU   A 1 206 ? -19.71320 -28.68021 23.31017  1.000 40.37317 ? 185 LEU   A C   1 
ATOM   1426 O O   . LEU   A 1 206 ? -20.90708 -28.80438 23.60740  1.000 41.16796 ? 185 LEU   A O   1 
ATOM   1427 C CB  . LEU   A 1 206 ? -18.91167 -26.49189 22.38324  1.000 30.98629 ? 185 LEU   A CB  1 
ATOM   1428 C CG  . LEU   A 1 206 ? -19.01078 -24.98941 22.64552  1.000 27.35719 ? 185 LEU   A CG  1 
ATOM   1429 C CD1 . LEU   A 1 206 ? -18.58424 -24.20269 21.40989  1.000 28.20696 ? 185 LEU   A CD1 1 
ATOM   1430 C CD2 . LEU   A 1 206 ? -20.41246 -24.61097 23.08109  1.000 33.00950 ? 185 LEU   A CD2 1 
ATOM   1431 N N   . ILE   A 1 207 ? -19.02598 -29.65322 22.70761  1.000 38.65171 ? 186 ILE   A N   1 
ATOM   1432 C CA  . ILE   A 1 207 ? -19.67519 -30.91121 22.34882  1.000 43.38919 ? 186 ILE   A CA  1 
ATOM   1433 C C   . ILE   A 1 207 ? -20.01771 -31.71712 23.59763  1.000 49.65397 ? 186 ILE   A C   1 
ATOM   1434 O O   . ILE   A 1 207 ? -21.08542 -32.33772 23.67884  1.000 52.19317 ? 186 ILE   A O   1 
ATOM   1435 C CB  . ILE   A 1 207 ? -18.78699 -31.70643 21.37385  1.000 43.23251 ? 186 ILE   A CB  1 
ATOM   1436 C CG1 . ILE   A 1 207 ? -18.93304 -31.14856 19.95680  1.000 45.32960 ? 186 ILE   A CG1 1 
ATOM   1437 C CG2 . ILE   A 1 207 ? -19.14037 -33.18717 21.39480  1.000 41.71186 ? 186 ILE   A CG2 1 
ATOM   1438 C CD1 . ILE   A 1 207 ? -17.82111 -31.55800 19.02443  1.000 41.36723 ? 186 ILE   A CD1 1 
ATOM   1439 N N   . ARG   A 1 208 ? -19.12699 -31.71200 24.59327  1.000 49.59491 ? 187 ARG   A N   1 
ATOM   1440 C CA  . ARG   A 1 208 ? -19.38222 -32.45153 25.82684  1.000 45.30454 ? 187 ARG   A CA  1 
ATOM   1441 C C   . ARG   A 1 208 ? -20.62659 -31.93546 26.54080  1.000 51.71373 ? 187 ARG   A C   1 
ATOM   1442 O O   . ARG   A 1 208 ? -21.40556 -32.72152 27.09333  1.000 53.59227 ? 187 ARG   A O   1 
ATOM   1443 C CB  . ARG   A 1 208 ? -18.16377 -32.36870 26.74687  1.000 48.27011 ? 187 ARG   A CB  1 
ATOM   1444 C CG  . ARG   A 1 208 ? -16.87478 -32.88859 26.13120  1.000 42.21700 ? 187 ARG   A CG  1 
ATOM   1445 C CD  . ARG   A 1 208 ? -15.90497 -33.37345 27.19522  1.000 51.82388 ? 187 ARG   A CD  1 
ATOM   1446 N NE  . ARG   A 1 208 ? -14.62239 -33.80175 26.64644  1.000 47.21065 ? 187 ARG   A NE  1 
ATOM   1447 C CZ  . ARG   A 1 208 ? -14.43176 -34.92005 25.95848  1.000 45.54622 ? 187 ARG   A CZ  1 
ATOM   1448 N NH1 . ARG   A 1 208 ? -15.42747 -35.75206 25.69832  1.000 47.72799 ? 187 ARG   A NH1 1 
ATOM   1449 N NH2 . ARG   A 1 208 ? -13.21020 -35.21217 25.52098  1.000 54.50750 ? 187 ARG   A NH2 1 
ATOM   1450 N N   . ARG   A 1 209 ? -20.83112 -30.61992 26.54193  1.000 47.82039 ? 188 ARG   A N   1 
ATOM   1451 C CA  . ARG   A 1 209 ? -21.97071 -30.02155 27.22579  1.000 49.79608 ? 188 ARG   A CA  1 
ATOM   1452 C C   . ARG   A 1 209 ? -23.24713 -30.03030 26.39251  1.000 56.47581 ? 188 ARG   A C   1 
ATOM   1453 O O   . ARG   A 1 209 ? -24.29334 -29.60743 26.89709  1.000 58.18284 ? 188 ARG   A O   1 
ATOM   1454 C CB  . ARG   A 1 209 ? -21.63962 -28.58442 27.63949  1.000 50.51485 ? 188 ARG   A CB  1 
ATOM   1455 C CG  . ARG   A 1 209 ? -20.56427 -28.47185 28.70704  1.000 44.94367 ? 188 ARG   A CG  1 
ATOM   1456 C CD  . ARG   A 1 209 ? -19.63777 -27.29297 28.44571  1.000 50.48453 ? 188 ARG   A CD  1 
ATOM   1457 N NE  . ARG   A 1 209 ? -20.36546 -26.05905 28.17311  1.000 52.89272 ? 188 ARG   A NE  1 
ATOM   1458 C CZ  . ARG   A 1 209 ? -19.83126 -24.98451 27.60781  1.000 50.41467 ? 188 ARG   A CZ  1 
ATOM   1459 N NH1 . ARG   A 1 209 ? -18.56645 -24.96396 27.21986  1.000 45.41533 ? 188 ARG   A NH1 1 
ATOM   1460 N NH2 . ARG   A 1 209 ? -20.58514 -23.90353 27.42616  1.000 45.57868 ? 188 ARG   A NH2 1 
ATOM   1461 N N   . LEU   A 1 210 ? -23.19090 -30.48855 25.14149  1.000 53.86723 ? 189 LEU   A N   1 
ATOM   1462 C CA  . LEU   A 1 210 ? -24.39080 -30.49936 24.30802  1.000 52.19797 ? 189 LEU   A CA  1 
ATOM   1463 C C   . LEU   A 1 210 ? -25.53018 -31.33169 24.88993  1.000 59.50011 ? 189 LEU   A C   1 
ATOM   1464 O O   . LEU   A 1 210 ? -26.67643 -30.84965 24.86268  1.000 56.33322 ? 189 LEU   A O   1 
ATOM   1465 C CB  . LEU   A 1 210 ? -24.03964 -30.97133 22.89049  1.000 49.88847 ? 189 LEU   A CB  1 
ATOM   1466 C CG  . LEU   A 1 210 ? -25.16832 -30.85619 21.86145  1.000 55.70368 ? 189 LEU   A CG  1 
ATOM   1467 C CD1 . LEU   A 1 210 ? -25.64538 -29.41672 21.73799  1.000 51.78175 ? 189 LEU   A CD1 1 
ATOM   1468 C CD2 . LEU   A 1 210 ? -24.72962 -31.39436 20.50769  1.000 50.64734 ? 189 LEU   A CD2 1 
ATOM   1469 N N   . PRO   A 1 211 ? -25.31876 -32.55657 25.39551  1.000 65.13202 ? 190 PRO   A N   1 
ATOM   1470 C CA  . PRO   A 1 211 ? -26.44297 -33.26276 26.03725  1.000 61.46719 ? 190 PRO   A CA  1 
ATOM   1471 C C   . PRO   A 1 211 ? -27.03013 -32.50984 27.21839  1.000 60.67331 ? 190 PRO   A C   1 
ATOM   1472 O O   . PRO   A 1 211 ? -28.25391 -32.50806 27.40243  1.000 57.44212 ? 190 PRO   A O   1 
ATOM   1473 C CB  . PRO   A 1 211 ? -25.81903 -34.60045 26.46619  1.000 51.60012 ? 190 PRO   A CB  1 
ATOM   1474 C CG  . PRO   A 1 211 ? -24.34396 -34.36158 26.46498  1.000 53.18467 ? 190 PRO   A CG  1 
ATOM   1475 C CD  . PRO   A 1 211 ? -24.11477 -33.40446 25.34593  1.000 58.20188 ? 190 PRO   A CD  1 
ATOM   1476 N N   . GLU   A 1 212 ? -26.18792 -31.86048 28.02431  1.000 60.54450 ? 191 GLU   A N   1 
ATOM   1477 C CA  . GLU   A 1 212 ? -26.68681 -31.11996 29.17768  1.000 64.52487 ? 191 GLU   A CA  1 
ATOM   1478 C C   . GLU   A 1 212 ? -27.33390 -29.80391 28.76166  1.000 61.84762 ? 191 GLU   A C   1 
ATOM   1479 O O   . GLU   A 1 212 ? -28.35956 -29.40741 29.32630  1.000 65.51246 ? 191 GLU   A O   1 
ATOM   1480 C CB  . GLU   A 1 212 ? -25.55069 -30.86887 30.16937  1.000 65.52413 ? 191 GLU   A CB  1 
ATOM   1481 C CG  . GLU   A 1 212 ? -26.01567 -30.50891 31.57030  1.000 77.01073 ? 191 GLU   A CG  1 
ATOM   1482 C CD  . GLU   A 1 212 ? -26.18788 -31.72903 32.45498  1.000 78.51506 ? 191 GLU   A CD  1 
ATOM   1483 O OE1 . GLU   A 1 212 ? -25.18935 -32.44340 32.68617  1.000 78.34715 ? 191 GLU   A OE1 1 
ATOM   1484 O OE2 . GLU   A 1 212 ? -27.32125 -31.97348 32.91948  1.000 77.27424 ? 191 GLU   A OE2 1 
ATOM   1485 N N   . ASN   A 1 213 ? -26.75116 -29.11616 27.78281  1.000 67.77130 ? 192 ASN   A N   1 
ATOM   1486 C CA  . ASN   A 1 213 ? -27.26639 -27.83443 27.29933  1.000 57.84818 ? 192 ASN   A CA  1 
ATOM   1487 C C   . ASN   A 1 213 ? -27.55104 -27.93510 25.80786  1.000 55.84936 ? 192 ASN   A C   1 
ATOM   1488 O O   . ASN   A 1 213 ? -26.62317 -27.82066 24.98674  1.000 56.12601 ? 192 ASN   A O   1 
ATOM   1489 C CB  . ASN   A 1 213 ? -26.27360 -26.70859 27.58515  1.000 55.61104 ? 192 ASN   A CB  1 
ATOM   1490 C CG  . ASN   A 1 213 ? -26.87510 -25.33152 27.37531  1.000 52.88821 ? 192 ASN   A CG  1 
ATOM   1491 O OD1 . ASN   A 1 213 ? -28.03099 -25.19924 26.97135  1.000 54.83633 ? 192 ASN   A OD1 1 
ATOM   1492 N ND2 . ASN   A 1 213 ? -26.09156 -24.29611 27.65439  1.000 46.55645 ? 192 ASN   A ND2 1 
ATOM   1493 N N   . PRO   A 1 214 ? -28.80581 -28.15455 25.40699  1.000 55.77358 ? 193 PRO   A N   1 
ATOM   1494 C CA  . PRO   A 1 214 ? -29.10361 -28.28257 23.97018  1.000 53.19962 ? 193 PRO   A CA  1 
ATOM   1495 C C   . PRO   A 1 214 ? -28.81523 -27.02475 23.16978  1.000 52.68603 ? 193 PRO   A C   1 
ATOM   1496 O O   . PRO   A 1 214 ? -28.53747 -27.11895 21.96736  1.000 41.18468 ? 193 PRO   A O   1 
ATOM   1497 C CB  . PRO   A 1 214 ? -30.59850 -28.63012 23.95532  1.000 53.98802 ? 193 PRO   A CB  1 
ATOM   1498 C CG  . PRO   A 1 214 ? -31.12688 -28.05397 25.22658  1.000 61.06117 ? 193 PRO   A CG  1 
ATOM   1499 C CD  . PRO   A 1 214 ? -30.02226 -28.20420 26.23540  1.000 54.93533 ? 193 PRO   A CD  1 
ATOM   1500 N N   . SER   A 1 215 ? -28.86619 -25.84937 23.79856  1.000 50.41035 ? 194 SER   A N   1 
ATOM   1501 C CA  . SER   A 1 215 ? -28.67431 -24.58669 23.09359  1.000 44.53136 ? 194 SER   A CA  1 
ATOM   1502 C C   . SER   A 1 215 ? -27.23281 -24.35278 22.66339  1.000 43.88761 ? 194 SER   A C   1 
ATOM   1503 O O   . SER   A 1 215 ? -26.95951 -23.33431 22.01755  1.000 44.16170 ? 194 SER   A O   1 
ATOM   1504 C CB  . SER   A 1 215 ? -29.14168 -23.42190 23.96659  1.000 42.73656 ? 194 SER   A CB  1 
ATOM   1505 O OG  . SER   A 1 215 ? -28.17795 -23.11391 24.95878  1.000 58.12847 ? 194 SER   A OG  1 
ATOM   1506 N N   . LEU   A 1 216 ? -26.31075 -25.25037 23.00352  1.000 44.71604 ? 195 LEU   A N   1 
ATOM   1507 C CA  . LEU   A 1 216 ? -24.91696 -25.11667 22.60160  1.000 39.84699 ? 195 LEU   A CA  1 
ATOM   1508 C C   . LEU   A 1 216 ? -24.65201 -25.63229 21.19399  1.000 42.60691 ? 195 LEU   A C   1 
ATOM   1509 O O   . LEU   A 1 216 ? -23.50765 -25.55739 20.73237  1.000 46.92502 ? 195 LEU   A O   1 
ATOM   1510 C CB  . LEU   A 1 216 ? -24.01364 -25.85052 23.59411  1.000 42.73160 ? 195 LEU   A CB  1 
ATOM   1511 C CG  . LEU   A 1 216 ? -23.96675 -25.28502 25.01317  1.000 48.97355 ? 195 LEU   A CG  1 
ATOM   1512 C CD1 . LEU   A 1 216 ? -22.69529 -25.73393 25.70407  1.000 42.37491 ? 195 LEU   A CD1 1 
ATOM   1513 C CD2 . LEU   A 1 216 ? -24.06325 -23.76694 25.00046  1.000 43.75827 ? 195 LEU   A CD2 1 
ATOM   1514 N N   . TYR   A 1 217 ? -25.67083 -26.15999 20.51143  1.000 38.60265 ? 196 TYR   A N   1 
ATOM   1515 C CA  . TYR   A 1 217 ? -25.48394 -26.64920 19.14903  1.000 38.01774 ? 196 TYR   A CA  1 
ATOM   1516 C C   . TYR   A 1 217 ? -25.04872 -25.52623 18.21602  1.000 37.98092 ? 196 TYR   A C   1 
ATOM   1517 O O   . TYR   A 1 217 ? -24.12279 -25.69275 17.41333  1.000 28.65994 ? 196 TYR   A O   1 
ATOM   1518 C CB  . TYR   A 1 217 ? -26.77641 -27.29867 18.65076  1.000 41.88166 ? 196 TYR   A CB  1 
ATOM   1519 C CG  . TYR   A 1 217 ? -26.69854 -27.84783 17.24337  1.000 41.82337 ? 196 TYR   A CG  1 
ATOM   1520 C CD1 . TYR   A 1 217 ? -26.28042 -29.15019 17.00829  1.000 38.10694 ? 196 TYR   A CD1 1 
ATOM   1521 C CD2 . TYR   A 1 217 ? -27.06553 -27.07026 16.15148  1.000 38.77164 ? 196 TYR   A CD2 1 
ATOM   1522 C CE1 . TYR   A 1 217 ? -26.21377 -29.65803 15.72499  1.000 42.30094 ? 196 TYR   A CE1 1 
ATOM   1523 C CE2 . TYR   A 1 217 ? -27.00188 -27.56921 14.86440  1.000 35.12053 ? 196 TYR   A CE2 1 
ATOM   1524 C CZ  . TYR   A 1 217 ? -26.57519 -28.86384 14.65712  1.000 41.92200 ? 196 TYR   A CZ  1 
ATOM   1525 O OH  . TYR   A 1 217 ? -26.51120 -29.36767 13.37802  1.000 49.91496 ? 196 TYR   A OH  1 
ATOM   1526 N N   . SER   A 1 218 ? -25.70471 -24.36765 18.31556  1.000 30.00850 ? 197 SER   A N   1 
ATOM   1527 C CA  . SER   A 1 218 ? -25.38212 -23.24925 17.43628  1.000 26.66330 ? 197 SER   A CA  1 
ATOM   1528 C C   . SER   A 1 218 ? -23.96132 -22.74629 17.65502  1.000 26.59970 ? 197 SER   A C   1 
ATOM   1529 O O   . SER   A 1 218 ? -23.33769 -22.22455 16.72366  1.000 27.26725 ? 197 SER   A O   1 
ATOM   1530 C CB  . SER   A 1 218 ? -26.38698 -22.11899 17.64985  1.000 28.87518 ? 197 SER   A CB  1 
ATOM   1531 O OG  . SER   A 1 218 ? -26.45501 -21.76645 19.02088  1.000 27.89205 ? 197 SER   A OG  1 
ATOM   1532 N N   . GLU   A 1 219 ? -23.43594 -22.88318 18.87320  1.000 29.90583 ? 198 GLU   A N   1 
ATOM   1533 C CA  . GLU   A 1 219 ? -22.06037 -22.46996 19.12770  1.000 30.37213 ? 198 GLU   A CA  1 
ATOM   1534 C C   . GLU   A 1 219 ? -21.06674 -23.40741 18.45181  1.000 25.82605 ? 198 GLU   A C   1 
ATOM   1535 O O   . GLU   A 1 219 ? -20.03703 -22.95784 17.93482  1.000 25.31480 ? 198 GLU   A O   1 
ATOM   1536 C CB  . GLU   A 1 219 ? -21.80550 -22.39759 20.63179  1.000 23.10508 ? 198 GLU   A CB  1 
ATOM   1537 C CG  . GLU   A 1 219 ? -22.71391 -21.42281 21.35972  1.000 27.24889 ? 198 GLU   A CG  1 
ATOM   1538 C CD  . GLU   A 1 219 ? -22.46724 -19.98247 20.95154  1.000 30.43265 ? 198 GLU   A CD  1 
ATOM   1539 O OE1 . GLU   A 1 219 ? -21.30014 -19.63029 20.68073  1.000 26.53901 ? 198 GLU   A OE1 1 
ATOM   1540 O OE2 . GLU   A 1 219 ? -23.44078 -19.20065 20.90278  1.000 34.95561 ? 198 GLU   A OE2 1 
ATOM   1541 N N   . ILE   A 1 220 ? -21.35525 -24.71278 18.44879  1.000 25.43230 ? 199 ILE   A N   1 
ATOM   1542 C CA  . ILE   A 1 220 ? -20.50090 -25.66561 17.74247  1.000 25.89853 ? 199 ILE   A CA  1 
ATOM   1543 C C   . ILE   A 1 220 ? -20.50742 -25.37407 16.24848  1.000 21.27484 ? 199 ILE   A C   1 
ATOM   1544 O O   . ILE   A 1 220 ? -19.46878 -25.44783 15.57949  1.000 23.23242 ? 199 ILE   A O   1 
ATOM   1545 C CB  . ILE   A 1 220 ? -20.94721 -27.11095 18.03470  1.000 24.16642 ? 199 ILE   A CB  1 
ATOM   1546 C CG1 . ILE   A 1 220 ? -20.67943 -27.47222 19.49358  1.000 31.17922 ? 199 ILE   A CG1 1 
ATOM   1547 C CG2 . ILE   A 1 220 ? -20.23758 -28.09000 17.11122  1.000 25.07558 ? 199 ILE   A CG2 1 
ATOM   1548 C CD1 . ILE   A 1 220 ? -21.79402 -28.26635 20.13651  1.000 36.62267 ? 199 ILE   A CD1 1 
ATOM   1549 N N   . ILE   A 1 221 ? -21.67813 -25.03760 15.70382  1.000 19.82146 ? 200 ILE   A N   1 
ATOM   1550 C CA  . ILE   A 1 221 ? -21.78107 -24.73664 14.28035  1.000 24.25125 ? 200 ILE   A CA  1 
ATOM   1551 C C   . ILE   A 1 221 ? -20.88839 -23.55870 13.91548  1.000 25.05070 ? 200 ILE   A C   1 
ATOM   1552 O O   . ILE   A 1 221 ? -20.18768 -23.58699 12.89645  1.000 21.04310 ? 200 ILE   A O   1 
ATOM   1553 C CB  . ILE   A 1 221 ? -23.24873 -24.47550 13.89530  1.000 26.29949 ? 200 ILE   A CB  1 
ATOM   1554 C CG1 . ILE   A 1 221 ? -24.09263 -25.73032 14.12239  1.000 35.52395 ? 200 ILE   A CG1 1 
ATOM   1555 C CG2 . ILE   A 1 221 ? -23.35067 -24.00844 12.45073  1.000 29.79168 ? 200 ILE   A CG2 1 
ATOM   1556 C CD1 . ILE   A 1 221 ? -23.50104 -26.98671 13.51419  1.000 30.36489 ? 200 ILE   A CD1 1 
ATOM   1557 N N   . MET   A 1 222 ? -20.89051 -22.50714 14.73727  1.000 21.63989 ? 201 MET   A N   1 
ATOM   1558 C CA  . MET   A 1 222 ? -20.10663 -21.32772 14.38580  1.000 24.09830 ? 201 MET   A CA  1 
ATOM   1559 C C   . MET   A 1 222 ? -18.61086 -21.63311 14.39891  1.000 18.64445 ? 201 MET   A C   1 
ATOM   1560 O O   . MET   A 1 222 ? -17.86788 -21.14788 13.53814  1.000 21.34564 ? 201 MET   A O   1 
ATOM   1561 C CB  . MET   A 1 222 ? -20.44940 -20.16000 15.31462  1.000 22.35099 ? 201 MET   A CB  1 
ATOM   1562 C CG  . MET   A 1 222 ? -19.46711 -18.99984 15.24602  1.000 23.00253 ? 201 MET   A CG  1 
ATOM   1563 S SD  . MET   A 1 222 ? -19.96958 -17.56356 16.21468  1.000 20.28414 ? 201 MET   A SD  1 
ATOM   1564 C CE  . MET   A 1 222 ? -19.51035 -18.04443 17.86430  1.000 24.50035 ? 201 MET   A CE  1 
ATOM   1565 N N   . ASP   A 1 223 ? -18.15024 -22.44394 15.35446  1.000 16.09491 ? 202 ASP   A N   1 
ATOM   1566 C CA  . ASP   A 1 223 ? -16.74294 -22.83676 15.36440  1.000 18.88293 ? 202 ASP   A CA  1 
ATOM   1567 C C   . ASP   A 1 223 ? -16.39389 -23.69532 14.14980  1.000 20.53676 ? 202 ASP   A C   1 
ATOM   1568 O O   . ASP   A 1 223 ? -15.31196 -23.54577 13.56802  1.000 14.42930 ? 202 ASP   A O   1 
ATOM   1569 C CB  . ASP   A 1 223 ? -16.40908 -23.56462 16.66752  1.000 23.40950 ? 202 ASP   A CB  1 
ATOM   1570 C CG  . ASP   A 1 223 ? -16.06062 -22.60796 17.79967  1.000 22.61490 ? 202 ASP   A CG  1 
ATOM   1571 O OD1 . ASP   A 1 223 ? -16.54438 -21.45642 17.78284  1.000 22.83975 ? 202 ASP   A OD1 1 
ATOM   1572 O OD2 . ASP   A 1 223 ? -15.30968 -23.01003 18.71310  1.000 20.85488 ? 202 ASP   A OD2 1 
ATOM   1573 N N   . ILE   A 1 224 ? -17.29437 -24.59759 13.74951  1.000 16.19554 ? 203 ILE   A N   1 
ATOM   1574 C CA  . ILE   A 1 224 ? -17.06555 -25.38939 12.54173  1.000 14.85165 ? 203 ILE   A CA  1 
ATOM   1575 C C   . ILE   A 1 224 ? -16.99706 -24.48483 11.31679  1.000 14.31107 ? 203 ILE   A C   1 
ATOM   1576 O O   . ILE   A 1 224 ? -16.14156 -24.66458 10.44142  1.000 12.89395 ? 203 ILE   A O   1 
ATOM   1577 C CB  . ILE   A 1 224 ? -18.15197 -26.47138 12.39050  1.000 13.82883 ? 203 ILE   A CB  1 
ATOM   1578 C CG1 . ILE   A 1 224 ? -17.97111 -27.55798 13.45366  1.000 20.63461 ? 203 ILE   A CG1 1 
ATOM   1579 C CG2 . ILE   A 1 224 ? -18.11716 -27.08266 10.99717  1.000 17.75458 ? 203 ILE   A CG2 1 
ATOM   1580 C CD1 . ILE   A 1 224 ? -19.09440 -28.57296 13.48842  1.000 22.86988 ? 203 ILE   A CD1 1 
ATOM   1581 N N   . ILE   A 1 225 ? -17.89399 -23.49871 11.23450  1.000 16.33054 ? 204 ILE   A N   1 
ATOM   1582 C CA  . ILE   A 1 225 ? -17.84944 -22.54645 10.12641  1.000 19.78760 ? 204 ILE   A CA  1 
ATOM   1583 C C   . ILE   A 1 225 ? -16.54219 -21.76453 10.15305  1.000 16.39684 ? 204 ILE   A C   1 
ATOM   1584 O O   . ILE   A 1 225 ? -15.93400 -21.50675 9.10694   1.000 11.15052 ? 204 ILE   A O   1 
ATOM   1585 C CB  . ILE   A 1 225 ? -19.07440 -21.61374 10.16947  1.000 18.56752 ? 204 ILE   A CB  1 
ATOM   1586 C CG1 . ILE   A 1 225 ? -20.34879 -22.39581 9.85373   1.000 14.84209 ? 204 ILE   A CG1 1 
ATOM   1587 C CG2 . ILE   A 1 225 ? -18.91291 -20.45917 9.19112   1.000 20.26530 ? 204 ILE   A CG2 1 
ATOM   1588 C CD1 . ILE   A 1 225 ? -21.61144 -21.59381 10.04614  1.000 15.64704 ? 204 ILE   A CD1 1 
ATOM   1589 N N   . THR   A 1 226 ? -16.08210 -21.38700 11.34927  1.000 16.29416 ? 205 THR   A N   1 
ATOM   1590 C CA  . THR   A 1 226 ? -14.79091 -20.71594 11.46502  1.000 18.43434 ? 205 THR   A CA  1 
ATOM   1591 C C   . THR   A 1 226 ? -13.67179 -21.58912 10.91217  1.000 14.31532 ? 205 THR   A C   1 
ATOM   1592 O O   . THR   A 1 226 ? -12.80409 -21.10933 10.17170  1.000 15.61173 ? 205 THR   A O   1 
ATOM   1593 C CB  . THR   A 1 226 ? -14.51288 -20.35985 12.92673  1.000 17.14196 ? 205 THR   A CB  1 
ATOM   1594 O OG1 . THR   A 1 226 ? -15.45183 -19.37326 13.37174  1.000 17.40906 ? 205 THR   A OG1 1 
ATOM   1595 C CG2 . THR   A 1 226 ? -13.10623 -19.81290 13.08149  1.000 16.93220 ? 205 THR   A CG2 1 
ATOM   1596 N N   . ALA   A 1 227 ? -13.68679 -22.88117 11.24936  1.000 13.09533 ? 206 ALA   A N   1 
ATOM   1597 C CA  . ALA   A 1 227 ? -12.65932 -23.79647 10.76467  1.000 13.55648 ? 206 ALA   A CA  1 
ATOM   1598 C C   . ALA   A 1 227 ? -12.74167 -24.00050 9.25626   1.000 13.10732 ? 206 ALA   A C   1 
ATOM   1599 O O   . ALA   A 1 227 ? -11.72200 -24.27365 8.61344   1.000 14.38047 ? 206 ALA   A O   1 
ATOM   1600 C CB  . ALA   A 1 227 ? -12.77536 -25.13968 11.48491  1.000 13.56673 ? 206 ALA   A CB  1 
ATOM   1601 N N   . ALA   A 1 228 ? -13.93822 -23.88405 8.67939   1.000 10.16670 ? 207 ALA   A N   1 
ATOM   1602 C CA  . ALA   A 1 228 ? -14.11120 -24.11341 7.25000   1.000 12.32345 ? 207 ALA   A CA  1 
ATOM   1603 C C   . ALA   A 1 228 ? -13.73855 -22.89733 6.41463   1.000 14.40806 ? 207 ALA   A C   1 
ATOM   1604 O O   . ALA   A 1 228 ? -13.35278 -23.04564 5.24968   1.000 10.72003 ? 207 ALA   A O   1 
ATOM   1605 C CB  . ALA   A 1 228 ? -15.55924 -24.50318 6.95687   1.000 14.21854 ? 207 ALA   A CB  1 
ATOM   1606 N N   . LEU   A 1 229 ? -13.83107 -21.70044 6.99084   1.000 15.72313 ? 208 LEU   A N   1 
ATOM   1607 C CA  . LEU   A 1 229 ? -13.85881 -20.45577 6.23133   1.000 15.74026 ? 208 LEU   A CA  1 
ATOM   1608 C C   . LEU   A 1 229 ? -12.50427 -19.76659 6.12042   1.000 13.54964 ? 208 LEU   A C   1 
ATOM   1609 O O   . LEU   A 1 229 ? -12.10081 -19.36827 5.02310   1.000 10.37320 ? 208 LEU   A O   1 
ATOM   1610 C CB  . LEU   A 1 229 ? -14.86352 -19.49493 6.87634   1.000 14.96553 ? 208 LEU   A CB  1 
ATOM   1611 C CG  . LEU   A 1 229 ? -15.38807 -18.31308 6.06252   1.000 21.50135 ? 208 LEU   A CG  1 
ATOM   1612 C CD1 . LEU   A 1 229 ? -15.62179 -18.69834 4.60779   1.000 19.67916 ? 208 LEU   A CD1 1 
ATOM   1613 C CD2 . LEU   A 1 229 ? -16.66384 -17.78149 6.69885   1.000 24.06414 ? 208 LEU   A CD2 1 
ATOM   1614 N N   . PHE   A 1 230 ? -11.79849 -19.60351 7.23322   1.000 13.00515 ? 209 PHE   A N   1 
ATOM   1615 C CA  . PHE   A 1 230 ? -10.74460 -18.60437 7.30993   1.000 13.47955 ? 209 PHE   A CA  1 
ATOM   1616 C C   . PHE   A 1 230 ? -9.37697  -19.19535 6.99262   1.000 12.33284 ? 209 PHE   A C   1 
ATOM   1617 O O   . PHE   A 1 230 ? -9.08502  -20.35401 7.30100   1.000 14.25936 ? 209 PHE   A O   1 
ATOM   1618 C CB  . PHE   A 1 230 ? -10.75550 -17.94738 8.69031   1.000 12.33914 ? 209 PHE   A CB  1 
ATOM   1619 C CG  . PHE   A 1 230 ? -11.94579 -17.05801 8.90639   1.000 10.55664 ? 209 PHE   A CG  1 
ATOM   1620 C CD1 . PHE   A 1 230 ? -11.98879 -15.79043 8.35219   1.000 12.13374 ? 209 PHE   A CD1 1 
ATOM   1621 C CD2 . PHE   A 1 230 ? -13.04083 -17.50611 9.62787   1.000 12.35810 ? 209 PHE   A CD2 1 
ATOM   1622 C CE1 . PHE   A 1 230 ? -13.08710 -14.97760 8.53007   1.000 19.61117 ? 209 PHE   A CE1 1 
ATOM   1623 C CE2 . PHE   A 1 230 ? -14.14483 -16.69745 9.80589   1.000 21.12247 ? 209 PHE   A CE2 1 
ATOM   1624 C CZ  . PHE   A 1 230 ? -14.16630 -15.42930 9.25905   1.000 18.86727 ? 209 PHE   A CZ  1 
ATOM   1625 N N   . ALA   A 1 231 ? -8.53803  -18.37695 6.35865   1.000 10.03530 ? 210 ALA   A N   1 
ATOM   1626 C CA  . ALA   A 1 231 ? -7.26011  -18.82511 5.82931   1.000 12.41690 ? 210 ALA   A CA  1 
ATOM   1627 C C   . ALA   A 1 231 ? -6.21094  -17.74356 6.06117   1.000 12.08629 ? 210 ALA   A C   1 
ATOM   1628 O O   . ALA   A 1 231 ? -6.49384  -16.68306 6.62944   1.000 10.75850 ? 210 ALA   A O   1 
ATOM   1629 C CB  . ALA   A 1 231 ? -7.38371  -19.17435 4.34303   1.000 10.32359 ? 210 ALA   A CB  1 
ATOM   1630 N N   . ASP   A 1 232 ? -4.98781  -18.01818 5.60872   1.000 12.03353 ? 211 ASP   A N   1 
ATOM   1631 C CA  . ASP   A 1 232 ? -3.83746  -17.15421 5.83346   1.000 9.51821  ? 211 ASP   A CA  1 
ATOM   1632 C C   . ASP   A 1 232 ? -3.38685  -16.51040 4.52696   1.000 12.63685 ? 211 ASP   A C   1 
ATOM   1633 O O   . ASP   A 1 232 ? -3.49674  -17.10585 3.45154   1.000 9.79349  ? 211 ASP   A O   1 
ATOM   1634 C CB  . ASP   A 1 232 ? -2.65943  -17.93552 6.42702   1.000 13.24426 ? 211 ASP   A CB  1 
ATOM   1635 C CG  . ASP   A 1 232 ? -2.99121  -18.59872 7.74930   1.000 11.83092 ? 211 ASP   A CG  1 
ATOM   1636 O OD1 . ASP   A 1 232 ? -4.15317  -18.52065 8.19831   1.000 9.61226  ? 211 ASP   A OD1 1 
ATOM   1637 O OD2 . ASP   A 1 232 ? -2.07277  -19.19769 8.34538   1.000 17.11815 ? 211 ASP   A OD2 1 
ATOM   1638 N N   . GLY   A 1 233 ? -2.85810  -15.29699 4.62643   1.000 7.48271  ? 212 GLY   A N   1 
ATOM   1639 C CA  . GLY   A 1 233 ? -2.31684  -14.63781 3.45275   1.000 9.19315  ? 212 GLY   A CA  1 
ATOM   1640 C C   . GLY   A 1 233 ? -1.98995  -13.19166 3.73881   1.000 8.68273  ? 212 GLY   A C   1 
ATOM   1641 O O   . GLY   A 1 233 ? -2.31043  -12.64691 4.79908   1.000 8.98250  ? 212 GLY   A O   1 
ATOM   1642 N N   . CYS   A 1 234 ? -1.34542  -12.56646 2.75674   1.000 10.16844 ? 213 CYS   A N   1 
ATOM   1643 C CA  . CYS   A 1 234 ? -0.94019  -11.17592 2.87759   1.000 9.95195  ? 213 CYS   A CA  1 
ATOM   1644 C C   . CYS   A 1 234 ? -1.11017  -10.46113 1.54399   1.000 13.05255 ? 213 CYS   A C   1 
ATOM   1645 O O   . CYS   A 1 234 ? -0.88741  -11.04517 0.47885   1.000 12.02241 ? 213 CYS   A O   1 
ATOM   1646 C CB  . CYS   A 1 234 ? 0.51349   -11.06611 3.36072   1.000 9.44931  ? 213 CYS   A CB  1 
ATOM   1647 S SG  . CYS   A 1 234 ? 1.19296   -9.39933  3.29254   1.000 10.36865 ? 213 CYS   A SG  1 
ATOM   1648 N N   . GLY   A 1 235 ? -1.51271  -9.19873  1.61237   1.000 13.29216 ? 214 GLY   A N   1 
ATOM   1649 C CA  . GLY   A 1 235 ? -1.58619  -8.35797  0.43451   1.000 11.17908 ? 214 GLY   A CA  1 
ATOM   1650 C C   . GLY   A 1 235 ? -1.00048  -6.99135  0.71816   1.000 10.62400 ? 214 GLY   A C   1 
ATOM   1651 O O   . GLY   A 1 235 ? -0.99502  -6.51918  1.85427   1.000 9.24937  ? 214 GLY   A O   1 
ATOM   1652 N N   . ALA   A 1 236 ? -0.49885  -6.35484  -0.34062  1.000 7.18975  ? 215 ALA   A N   1 
ATOM   1653 C CA  . ALA   A 1 236 ? 0.13183   -5.04867  -0.21570  1.000 8.66570  ? 215 ALA   A CA  1 
ATOM   1654 C C   . ALA   A 1 236 ? -0.25231  -4.16675  -1.39432  1.000 8.80504  ? 215 ALA   A C   1 
ATOM   1655 O O   . ALA   A 1 236 ? -0.47645  -4.65029  -2.50696  1.000 7.79517  ? 215 ALA   A O   1 
ATOM   1656 C CB  . ALA   A 1 236 ? 1.66033   -5.16289  -0.13064  1.000 9.50632  ? 215 ALA   A CB  1 
ATOM   1657 N N   . VAL   A 1 237 ? -0.31057  -2.86155  -1.14244  1.000 7.93552  ? 216 VAL   A N   1 
ATOM   1658 C CA  . VAL   A 1 237 ? -0.66603  -1.88659  -2.16574  1.000 8.31484  ? 216 VAL   A CA  1 
ATOM   1659 C C   . VAL   A 1 237 ? 0.24049   -0.66881  -2.02848  1.000 7.33082  ? 216 VAL   A C   1 
ATOM   1660 O O   . VAL   A 1 237 ? 0.55345   -0.23262  -0.91598  1.000 7.76166  ? 216 VAL   A O   1 
ATOM   1661 C CB  . VAL   A 1 237 ? -2.16280  -1.50219  -2.08206  1.000 9.20037  ? 216 VAL   A CB  1 
ATOM   1662 C CG1 . VAL   A 1 237 ? -2.53181  -1.02210  -0.68403  1.000 17.79322 ? 216 VAL   A CG1 1 
ATOM   1663 C CG2 . VAL   A 1 237 ? -2.51735  -0.46041  -3.13767  1.000 9.77068  ? 216 VAL   A CG2 1 
ATOM   1664 N N   . LEU   A 1 238 ? 0.69599   -0.14455  -3.16422  1.000 5.89690  ? 217 LEU   A N   1 
ATOM   1665 C CA  . LEU   A 1 238 ? 1.45050   1.10078   -3.20701  1.000 7.83089  ? 217 LEU   A CA  1 
ATOM   1666 C C   . LEU   A 1 238 ? 0.53030   2.20881   -3.70376  1.000 11.23359 ? 217 LEU   A C   1 
ATOM   1667 O O   . LEU   A 1 238 ? -0.07691  2.08399   -4.77324  1.000 7.85994  ? 217 LEU   A O   1 
ATOM   1668 C CB  . LEU   A 1 238 ? 2.68078   0.97542   -4.10653  1.000 9.51507  ? 217 LEU   A CB  1 
ATOM   1669 C CG  . LEU   A 1 238 ? 3.41019   2.28851   -4.41898  1.000 11.85076 ? 217 LEU   A CG  1 
ATOM   1670 C CD1 . LEU   A 1 238 ? 4.23136   2.73580   -3.22535  1.000 12.49098 ? 217 LEU   A CD1 1 
ATOM   1671 C CD2 . LEU   A 1 238 ? 4.29831   2.14564   -5.65331  1.000 13.13300 ? 217 LEU   A CD2 1 
ATOM   1672 N N   . MET   A 1 239 ? 0.42029   3.28235   -2.92345  1.000 11.05099 ? 218 MET   A N   1 
ATOM   1673 C CA  . MET   A 1 239 ? -0.43328  4.41116   -3.26296  1.000 13.02247 ? 218 MET   A CA  1 
ATOM   1674 C C   . MET   A 1 239 ? 0.38002   5.69501   -3.20114  1.000 10.63577 ? 218 MET   A C   1 
ATOM   1675 O O   . MET   A 1 239 ? 1.28753   5.83156   -2.37821  1.000 13.31391 ? 218 MET   A O   1 
ATOM   1676 C CB  . MET   A 1 239 ? -1.65442  4.50373   -2.32620  1.000 8.89789  ? 218 MET   A CB  1 
ATOM   1677 C CG  . MET   A 1 239 ? -2.48360  3.22594   -2.26454  1.000 10.85723 ? 218 MET   A CG  1 
ATOM   1678 S SD  . MET   A 1 239 ? -3.71165  3.19933   -0.93841  1.000 11.01077 ? 218 MET   A SD  1 
ATOM   1679 C CE  . MET   A 1 239 ? -4.70463  4.62448   -1.37693  1.000 10.91169 ? 218 MET   A CE  1 
ATOM   1680 N N   . VAL   A 1 240 ? 0.06498   6.63273   -4.09863  1.000 12.02300 ? 219 VAL   A N   1 
ATOM   1681 C CA  . VAL   A 1 240 ? 0.77921   7.90132   -4.17442  1.000 10.16589 ? 219 VAL   A CA  1 
ATOM   1682 C C   . VAL   A 1 240 ? -0.21175  9.04727   -4.32766  1.000 11.53235 ? 219 VAL   A C   1 
ATOM   1683 O O   . VAL   A 1 240 ? -1.34066  8.87101   -4.79147  1.000 12.62128 ? 219 VAL   A O   1 
ATOM   1684 C CB  . VAL   A 1 240 ? 1.79635   7.93677   -5.33947  1.000 12.67088 ? 219 VAL   A CB  1 
ATOM   1685 C CG1 . VAL   A 1 240 ? 2.80403   6.80307   -5.22165  1.000 7.76226  ? 219 VAL   A CG1 1 
ATOM   1686 C CG2 . VAL   A 1 240 ? 1.07708   7.89313   -6.68426  1.000 16.27216 ? 219 VAL   A CG2 1 
ATOM   1687 N N   . GLY   A 1 241 ? 0.23677   10.23879  -3.94238  1.000 14.70920 ? 220 GLY   A N   1 
ATOM   1688 C CA  . GLY   A 1 241 ? -0.52800  11.44449  -4.16898  1.000 17.72587 ? 220 GLY   A CA  1 
ATOM   1689 C C   . GLY   A 1 241 ? -0.46149  11.87438  -5.62318  1.000 17.82655 ? 220 GLY   A C   1 
ATOM   1690 O O   . GLY   A 1 241 ? 0.25164   11.30479  -6.45004  1.000 21.56844 ? 220 GLY   A O   1 
ATOM   1691 N N   . LYS   A 1 242 ? -1.22705  12.92323  -5.93513  1.000 24.64566 ? 221 LYS   A N   1 
ATOM   1692 C CA  . LYS   A 1 242 ? -1.36837  13.33738  -7.32785  1.000 22.76142 ? 221 LYS   A CA  1 
ATOM   1693 C C   . LYS   A 1 242 ? -0.06836  13.89051  -7.90062  1.000 28.18908 ? 221 LYS   A C   1 
ATOM   1694 O O   . LYS   A 1 242 ? 0.17514   13.75880  -9.10502  1.000 25.01102 ? 221 LYS   A O   1 
ATOM   1695 C CB  . LYS   A 1 242 ? -2.49171  14.36755  -7.46723  1.000 31.48718 ? 221 LYS   A CB  1 
ATOM   1696 C CG  . LYS   A 1 242 ? -2.14478  15.76593  -6.97807  1.000 34.87382 ? 221 LYS   A CG  1 
ATOM   1697 C CD  . LYS   A 1 242 ? -3.36437  16.67402  -6.98998  1.000 33.18429 ? 221 LYS   A CD  1 
ATOM   1698 C CE  . LYS   A 1 242 ? -4.51920  16.06916  -6.20883  1.000 43.11972 ? 221 LYS   A CE  1 
ATOM   1699 N NZ  . LYS   A 1 242 ? -4.26511  16.07327  -4.74005  1.000 51.16958 ? 221 LYS   A NZ  1 
ATOM   1700 N N   . GLU   A 1 243 ? 0.77355   14.50448  -7.07089  1.000 21.51626 ? 222 GLU   A N   1 
ATOM   1701 C CA  . GLU   A 1 243 ? 1.99834   15.13541  -7.54542  1.000 24.67250 ? 222 GLU   A CA  1 
ATOM   1702 C C   . GLU   A 1 243 ? 3.17267   14.16900  -7.63627  1.000 23.23034 ? 222 GLU   A C   1 
ATOM   1703 O O   . GLU   A 1 243 ? 4.25405   14.57231  -8.07646  1.000 19.92798 ? 222 GLU   A O   1 
ATOM   1704 C CB  . GLU   A 1 243 ? 2.36937   16.31343  -6.63864  1.000 29.80825 ? 222 GLU   A CB  1 
ATOM   1705 C CG  . GLU   A 1 243 ? 1.84556   17.65443  -7.12967  1.000 36.89051 ? 222 GLU   A CG  1 
ATOM   1706 C CD  . GLU   A 1 243 ? 1.73743   18.68195  -6.01882  1.000 40.70690 ? 222 GLU   A CD  1 
ATOM   1707 O OE1 . GLU   A 1 243 ? 2.68537   18.79146  -5.21326  1.000 37.84349 ? 222 GLU   A OE1 1 
ATOM   1708 O OE2 . GLU   A 1 243 ? 0.70046   19.37426  -5.94619  1.000 44.77809 ? 222 GLU   A OE2 1 
ATOM   1709 N N   . HIS   A 1 244 ? 2.99060   12.91456  -7.23118  1.000 19.55870 ? 223 HIS   A N   1 
ATOM   1710 C CA  . HIS   A 1 244 ? 4.07003   11.94418  -7.28587  1.000 16.00302 ? 223 HIS   A CA  1 
ATOM   1711 C C   . HIS   A 1 244 ? 4.38154   11.57905  -8.73707  1.000 20.32832 ? 223 HIS   A C   1 
ATOM   1712 O O   . HIS   A 1 244 ? 3.48442   11.55292  -9.58428  1.000 19.11431 ? 223 HIS   A O   1 
ATOM   1713 C CB  . HIS   A 1 244 ? 3.69255   10.69246  -6.49902  1.000 14.64156 ? 223 HIS   A CB  1 
ATOM   1714 C CG  . HIS   A 1 244 ? 4.84748   9.78814   -6.19851  1.000 19.44818 ? 223 HIS   A CG  1 
ATOM   1715 N ND1 . HIS   A 1 244 ? 5.29465   8.83127   -7.08444  1.000 17.24400 ? 223 HIS   A ND1 1 
ATOM   1716 C CD2 . HIS   A 1 244 ? 5.64644   9.69463   -5.10888  1.000 15.12545 ? 223 HIS   A CD2 1 
ATOM   1717 C CE1 . HIS   A 1 244 ? 6.31841   8.18658   -6.55327  1.000 19.16064 ? 223 HIS   A CE1 1 
ATOM   1718 N NE2 . HIS   A 1 244 ? 6.55213   8.69119   -5.35483  1.000 19.03867 ? 223 HIS   A NE2 1 
ATOM   1719 N N   . PRO   A 1 245 ? 5.65165   11.30284  -9.04988  1.000 21.98556 ? 224 PRO   A N   1 
ATOM   1720 C CA  . PRO   A 1 245 ? 6.00190   10.93227  -10.43237 1.000 20.29377 ? 224 PRO   A CA  1 
ATOM   1721 C C   . PRO   A 1 245 ? 5.26351   9.70875   -10.94723 1.000 29.62198 ? 224 PRO   A C   1 
ATOM   1722 O O   . PRO   A 1 245 ? 4.98838   9.62648   -12.15118 1.000 32.56685 ? 224 PRO   A O   1 
ATOM   1723 C CB  . PRO   A 1 245 ? 7.51385   10.68249  -10.34985 1.000 21.96487 ? 224 PRO   A CB  1 
ATOM   1724 C CG  . PRO   A 1 245 ? 7.96608   11.53435  -9.21509  1.000 26.77021 ? 224 PRO   A CG  1 
ATOM   1725 C CD  . PRO   A 1 245 ? 6.84578   11.51647  -8.21392  1.000 19.04830 ? 224 PRO   A CD  1 
ATOM   1726 N N   . LEU   A 1 246 ? 4.93312   8.75446   -10.07683 1.000 23.12021 ? 225 LEU   A N   1 
ATOM   1727 C CA  . LEU   A 1 246 ? 4.23885   7.54564   -10.50158 1.000 23.06979 ? 225 LEU   A CA  1 
ATOM   1728 C C   . LEU   A 1 246 ? 2.75255   7.76378   -10.75194 1.000 24.57253 ? 225 LEU   A C   1 
ATOM   1729 O O   . LEU   A 1 246 ? 2.09407   6.86070   -11.27989 1.000 28.82557 ? 225 LEU   A O   1 
ATOM   1730 C CB  . LEU   A 1 246 ? 4.41761   6.44151   -9.45698  1.000 19.61355 ? 225 LEU   A CB  1 
ATOM   1731 C CG  . LEU   A 1 246 ? 5.81381   5.83790   -9.31350  1.000 19.55569 ? 225 LEU   A CG  1 
ATOM   1732 C CD1 . LEU   A 1 246 ? 5.83423   4.83387   -8.16844  1.000 18.52360 ? 225 LEU   A CD1 1 
ATOM   1733 C CD2 . LEU   A 1 246 ? 6.25793   5.18308   -10.61409 1.000 19.96884 ? 225 LEU   A CD2 1 
ATOM   1734 N N   . ALA   A 1 247 ? 2.21031   8.92868   -10.39272 1.000 23.13355 ? 226 ALA   A N   1 
ATOM   1735 C CA  . ALA   A 1 247 ? 0.78171   9.20772   -10.54471 1.000 27.04418 ? 226 ALA   A CA  1 
ATOM   1736 C C   . ALA   A 1 247 ? 0.48292   9.48193   -12.01691 1.000 30.73227 ? 226 ALA   A C   1 
ATOM   1737 O O   . ALA   A 1 247 ? 0.29096   10.62006  -12.45153 1.000 30.34512 ? 226 ALA   A O   1 
ATOM   1738 C CB  . ALA   A 1 247 ? 0.36796   10.37793  -9.66172  1.000 23.19721 ? 226 ALA   A CB  1 
ATOM   1739 N N   . LYS   A 1 248 ? 0.42940   8.40654   -12.79491 1.000 31.87007 ? 227 LYS   A N   1 
ATOM   1740 C CA  . LYS   A 1 248 ? 0.20027   8.48953   -14.22878 1.000 32.04896 ? 227 LYS   A CA  1 
ATOM   1741 C C   . LYS   A 1 248 ? -1.24069  8.12886   -14.56669 1.000 37.91119 ? 227 LYS   A C   1 
ATOM   1742 O O   . LYS   A 1 248 ? -1.89999  7.37729   -13.84399 1.000 30.90798 ? 227 LYS   A O   1 
ATOM   1743 C CB  . LYS   A 1 248 ? 1.15625   7.56700   -14.98785 1.000 38.04460 ? 227 LYS   A CB  1 
ATOM   1744 C CG  . LYS   A 1 248 ? 2.50818   8.19182   -15.29588 1.000 38.36373 ? 227 LYS   A CG  1 
ATOM   1745 C CD  . LYS   A 1 248 ? 3.60042   7.13818   -15.35623 1.000 39.45962 ? 227 LYS   A CD  1 
ATOM   1746 C CE  . LYS   A 1 248 ? 4.08538   6.92539   -16.77927 1.000 46.55154 ? 227 LYS   A CE  1 
ATOM   1747 N NZ  . LYS   A 1 248 ? 5.10998   5.84443   -16.86176 1.000 47.79592 ? 227 LYS   A NZ  1 
ATOM   1748 N N   . SER   A 1 249 ? -1.72067  8.67370   -15.68178 1.000 45.26822 ? 228 SER   A N   1 
ATOM   1749 C CA  . SER   A 1 249 ? -3.07717  8.39830   -16.12975 1.000 40.36529 ? 228 SER   A CA  1 
ATOM   1750 C C   . SER   A 1 249 ? -3.22900  6.92923   -16.51240 1.000 32.64609 ? 228 SER   A C   1 
ATOM   1751 O O   . SER   A 1 249 ? -2.28672  6.27990   -16.97515 1.000 37.77618 ? 228 SER   A O   1 
ATOM   1752 C CB  . SER   A 1 249 ? -3.44158  9.29693   -17.31280 1.000 42.98140 ? 228 SER   A CB  1 
ATOM   1753 O OG  . SER   A 1 249 ? -3.09388  8.69180   -18.54576 1.000 52.17064 ? 228 SER   A OG  1 
ATOM   1754 N N   . GLY   A 1 250 ? -4.43478  6.40514   -16.30540 1.000 32.45404 ? 229 GLY   A N   1 
ATOM   1755 C CA  . GLY   A 1 250 ? -4.73508  5.01292   -16.53805 1.000 30.32954 ? 229 GLY   A CA  1 
ATOM   1756 C C   . GLY   A 1 250 ? -4.70021  4.15000   -15.29370 1.000 30.63558 ? 229 GLY   A C   1 
ATOM   1757 O O   . GLY   A 1 250 ? -5.26956  3.05238   -15.30109 1.000 27.66618 ? 229 GLY   A O   1 
ATOM   1758 N N   . LEU   A 1 251 ? -4.04348  4.61233   -14.23177 1.000 24.31293 ? 230 LEU   A N   1 
ATOM   1759 C CA  . LEU   A 1 251 ? -4.08330  3.90963   -12.96191 1.000 25.64319 ? 230 LEU   A CA  1 
ATOM   1760 C C   . LEU   A 1 251 ? -5.37594  4.24441   -12.21899 1.000 20.00889 ? 230 LEU   A C   1 
ATOM   1761 O O   . LEU   A 1 251 ? -5.94969  5.31926   -12.41341 1.000 20.64802 ? 230 LEU   A O   1 
ATOM   1762 C CB  . LEU   A 1 251 ? -2.87851  4.28678   -12.10416 1.000 20.46863 ? 230 LEU   A CB  1 
ATOM   1763 C CG  . LEU   A 1 251 ? -1.50448  3.95548   -12.69293 1.000 26.04624 ? 230 LEU   A CG  1 
ATOM   1764 C CD1 . LEU   A 1 251 ? -0.39866  4.64073   -11.90222 1.000 25.09498 ? 230 LEU   A CD1 1 
ATOM   1765 C CD2 . LEU   A 1 251 ? -1.28804  2.44811   -12.74252 1.000 19.60267 ? 230 LEU   A CD2 1 
ATOM   1766 N N   . PRO   A 1 252 ? -5.86036  3.33858   -11.36906 1.000 17.99547 ? 231 PRO   A N   1 
ATOM   1767 C CA  . PRO   A 1 252 ? -7.09039  3.62627   -10.61589 1.000 16.17152 ? 231 PRO   A CA  1 
ATOM   1768 C C   . PRO   A 1 252 ? -6.88600  4.78986   -9.65455  1.000 17.61433 ? 231 PRO   A C   1 
ATOM   1769 O O   . PRO   A 1 252 ? -5.89118  4.84796   -8.92788  1.000 16.35310 ? 231 PRO   A O   1 
ATOM   1770 C CB  . PRO   A 1 252 ? -7.37360  2.31635   -9.86830  1.000 16.40460 ? 231 PRO   A CB  1 
ATOM   1771 C CG  . PRO   A 1 252 ? -6.10064  1.54521   -9.90181  1.000 20.31169 ? 231 PRO   A CG  1 
ATOM   1772 C CD  . PRO   A 1 252 ? -5.34597  1.98122   -11.11661 1.000 18.10480 ? 231 PRO   A CD  1 
ATOM   1773 N N   . GLN   A 1 253 ? -7.83561  5.72035   -9.66130  1.000 14.13758 ? 232 GLN   A N   1 
ATOM   1774 C CA  . GLN   A 1 253 ? -7.85156  6.83586   -8.72673  1.000 15.63240 ? 232 GLN   A CA  1 
ATOM   1775 C C   . GLN   A 1 253 ? -8.79806  6.51079   -7.58031  1.000 14.33156 ? 232 GLN   A C   1 
ATOM   1776 O O   . GLN   A 1 253 ? -9.90294  6.00958   -7.80421  1.000 10.07262 ? 232 GLN   A O   1 
ATOM   1777 C CB  . GLN   A 1 253 ? -8.33170  8.12675   -9.39376  1.000 18.85093 ? 232 GLN   A CB  1 
ATOM   1778 C CG  . GLN   A 1 253 ? -7.26178  9.09866   -9.84524  1.000 31.89033 ? 232 GLN   A CG  1 
ATOM   1779 C CD  . GLN   A 1 253 ? -7.68769  9.84972   -11.09401 1.000 30.66183 ? 232 GLN   A CD  1 
ATOM   1780 O OE1 . GLN   A 1 253 ? -8.80208  10.36988  -11.16237 1.000 31.22122 ? 232 GLN   A OE1 1 
ATOM   1781 N NE2 . GLN   A 1 253 ? -6.82225  9.88775   -12.09293 1.000 32.91380 ? 232 GLN   A NE2 1 
ATOM   1782 N N   . VAL   A 1 254 ? -8.37638  6.81054   -6.35486  1.000 13.22386 ? 233 VAL   A N   1 
ATOM   1783 C CA  . VAL   A 1 254 ? -9.28140  6.79428   -5.20947  1.000 9.26986  ? 233 VAL   A CA  1 
ATOM   1784 C C   . VAL   A 1 254 ? -9.94413  8.16664   -5.16402  1.000 11.66036 ? 233 VAL   A C   1 
ATOM   1785 O O   . VAL   A 1 254 ? -9.34899  9.13926   -4.70469  1.000 14.85866 ? 233 VAL   A O   1 
ATOM   1786 C CB  . VAL   A 1 254 ? -8.55540  6.48121   -3.90050  1.000 13.41927 ? 233 VAL   A CB  1 
ATOM   1787 C CG1 . VAL   A 1 254 ? -9.55071  6.48103   -2.74892  1.000 13.46708 ? 233 VAL   A CG1 1 
ATOM   1788 C CG2 . VAL   A 1 254 ? -7.83143  5.14734   -3.98852  1.000 8.82477  ? 233 VAL   A CG2 1 
ATOM   1789 N N   . ILE   A 1 255 ? -11.18243 8.25284   -5.63972  1.000 14.69136 ? 234 ILE   A N   1 
ATOM   1790 C CA  . ILE   A 1 255 ? -11.83229 9.55590   -5.67150  1.000 13.24368 ? 234 ILE   A CA  1 
ATOM   1791 C C   . ILE   A 1 255 ? -12.64257 9.83573   -4.40658  1.000 8.82146  ? 234 ILE   A C   1 
ATOM   1792 O O   . ILE   A 1 255 ? -12.79623 11.00060  -4.02760  1.000 11.04584 ? 234 ILE   A O   1 
ATOM   1793 C CB  . ILE   A 1 255 ? -12.69213 9.70639   -6.93636  1.000 24.04047 ? 234 ILE   A CB  1 
ATOM   1794 C CG1 . ILE   A 1 255 ? -13.60968 8.50463   -7.12396  1.000 16.41568 ? 234 ILE   A CG1 1 
ATOM   1795 C CG2 . ILE   A 1 255 ? -11.80351 9.88467   -8.16138  1.000 26.41142 ? 234 ILE   A CG2 1 
ATOM   1796 C CD1 . ILE   A 1 255 ? -14.48236 8.62740   -8.35447  1.000 24.10569 ? 234 ILE   A CD1 1 
ATOM   1797 N N   . ASP   A 1 256 ? -13.14715 8.80592   -3.72723  1.000 8.94705  ? 235 ASP   A N   1 
ATOM   1798 C CA  . ASP   A 1 256 ? -13.84607 9.02426   -2.46425  1.000 8.27440  ? 235 ASP   A CA  1 
ATOM   1799 C C   . ASP   A 1 256 ? -13.90635 7.70820   -1.69926  1.000 9.83876  ? 235 ASP   A C   1 
ATOM   1800 O O   . ASP   A 1 256 ? -13.61528 6.63838   -2.23796  1.000 9.75950  ? 235 ASP   A O   1 
ATOM   1801 C CB  . ASP   A 1 256 ? -15.25007 9.59897   -2.69329  1.000 9.76390  ? 235 ASP   A CB  1 
ATOM   1802 C CG  . ASP   A 1 256 ? -15.74549 10.43466  -1.51994  1.000 13.18556 ? 235 ASP   A CG  1 
ATOM   1803 O OD1 . ASP   A 1 256 ? -15.07803 10.45912  -0.46186  1.000 8.70774  ? 235 ASP   A OD1 1 
ATOM   1804 O OD2 . ASP   A 1 256 ? -16.80733 11.07507  -1.66282  1.000 13.88976 ? 235 ASP   A OD2 1 
ATOM   1805 N N   . ASN   A 1 257 ? -14.26420 7.80863   -0.41917  1.000 9.75423  ? 236 ASN   A N   1 
ATOM   1806 C CA  . ASN   A 1 257 ? -14.44830 6.64242   0.43600   1.000 9.34016  ? 236 ASN   A CA  1 
ATOM   1807 C C   . ASN   A 1 257 ? -15.37507 7.02921   1.57842   1.000 10.04370 ? 236 ASN   A C   1 
ATOM   1808 O O   . ASN   A 1 257 ? -15.55634 8.21261   1.87483   1.000 9.24679  ? 236 ASN   A O   1 
ATOM   1809 C CB  . ASN   A 1 257 ? -13.11435 6.10737   0.97407   1.000 13.55893 ? 236 ASN   A CB  1 
ATOM   1810 C CG  . ASN   A 1 257 ? -12.33371 7.14926   1.75332   1.000 16.18566 ? 236 ASN   A CG  1 
ATOM   1811 O OD1 . ASN   A 1 257 ? -11.39631 7.75245   1.23242   1.000 23.86237 ? 236 ASN   A OD1 1 
ATOM   1812 N ND2 . ASN   A 1 257 ? -12.70871 7.35818   3.01011   1.000 16.91576 ? 236 ASN   A ND2 1 
ATOM   1813 N N   . ARG   A 1 258 ? -15.95928 6.01655   2.21897   1.000 9.64115  ? 237 ARG   A N   1 
ATOM   1814 C CA  . ARG   A 1 258 ? -16.90127 6.26584   3.30289   1.000 10.32648 ? 237 ARG   A CA  1 
ATOM   1815 C C   . ARG   A 1 258 ? -16.99360 5.03920   4.20038   1.000 7.55446  ? 237 ARG   A C   1 
ATOM   1816 O O   . ARG   A 1 258 ? -16.84768 3.90406   3.73805   1.000 8.92380  ? 237 ARG   A O   1 
ATOM   1817 C CB  . ARG   A 1 258 ? -18.28668 6.62798   2.75830   1.000 10.03319 ? 237 ARG   A CB  1 
ATOM   1818 C CG  . ARG   A 1 258 ? -19.23457 7.21310   3.79368   1.000 11.75369 ? 237 ARG   A CG  1 
ATOM   1819 C CD  . ARG   A 1 258 ? -20.51515 7.68137   3.13023   1.000 10.34434 ? 237 ARG   A CD  1 
ATOM   1820 N NE  . ARG   A 1 258 ? -20.26779 8.82083   2.25499   1.000 12.18195 ? 237 ARG   A NE  1 
ATOM   1821 C CZ  . ARG   A 1 258 ? -21.21368 9.61950   1.78038   1.000 19.85506 ? 237 ARG   A CZ  1 
ATOM   1822 N NH1 . ARG   A 1 258 ? -22.48828 9.43832   2.08633   1.000 13.12139 ? 237 ARG   A NH1 1 
ATOM   1823 N NH2 . ARG   A 1 258 ? -20.87273 10.62230  0.97577   1.000 12.24250 ? 237 ARG   A NH2 1 
ATOM   1824 N N   . SER   A 1 259 ? -17.25745 5.28662   5.48420   1.000 10.42687 ? 238 SER   A N   1 
ATOM   1825 C CA  . SER   A 1 259 ? -17.43206 4.25655   6.49897   1.000 6.34572  ? 238 SER   A CA  1 
ATOM   1826 C C   . SER   A 1 259 ? -18.87326 4.23692   6.99414   1.000 6.40692  ? 238 SER   A C   1 
ATOM   1827 O O   . SER   A 1 259 ? -19.59778 5.23108   6.91023   1.000 5.74146  ? 238 SER   A O   1 
ATOM   1828 C CB  . SER   A 1 259 ? -16.49735 4.48704   7.69395   1.000 10.56168 ? 238 SER   A CB  1 
ATOM   1829 O OG  . SER   A 1 259 ? -15.14265 4.61810   7.29368   1.000 6.02392  ? 238 SER   A OG  1 
ATOM   1830 N N   . PHE   A 1 260 ? -19.27417 3.08876   7.53604   1.000 6.23173  ? 239 PHE   A N   1 
ATOM   1831 C CA  . PHE   A 1 260 ? -20.59347 2.93256   8.13533   1.000 9.51213  ? 239 PHE   A CA  1 
ATOM   1832 C C   . PHE   A 1 260 ? -20.50755 1.87154   9.22101   1.000 10.81569 ? 239 PHE   A C   1 
ATOM   1833 O O   . PHE   A 1 260 ? -19.90478 0.81610   9.00652   1.000 12.81373 ? 239 PHE   A O   1 
ATOM   1834 C CB  . PHE   A 1 260 ? -21.63753 2.53932   7.08266   1.000 8.64474  ? 239 PHE   A CB  1 
ATOM   1835 C CG  . PHE   A 1 260 ? -23.05839 2.77516   7.51587   1.000 12.18190 ? 239 PHE   A CG  1 
ATOM   1836 C CD1 . PHE   A 1 260 ? -23.72377 1.83953   8.29347   1.000 10.62426 ? 239 PHE   A CD1 1 
ATOM   1837 C CD2 . PHE   A 1 260 ? -23.72754 3.93194   7.14715   1.000 13.47289 ? 239 PHE   A CD2 1 
ATOM   1838 C CE1 . PHE   A 1 260 ? -25.02841 2.05238   8.69624   1.000 15.17301 ? 239 PHE   A CE1 1 
ATOM   1839 C CE2 . PHE   A 1 260 ? -25.03583 4.15012   7.54668   1.000 15.01094 ? 239 PHE   A CE2 1 
ATOM   1840 C CZ  . PHE   A 1 260 ? -25.68385 3.21028   8.32447   1.000 15.59605 ? 239 PHE   A CZ  1 
ATOM   1841 N N   . LEU   A 1 261 ? -21.10212 2.15151   10.37926  1.000 7.75550  ? 240 LEU   A N   1 
ATOM   1842 C CA  . LEU   A 1 261 ? -21.16782 1.19400   11.47675  1.000 8.05754  ? 240 LEU   A CA  1 
ATOM   1843 C C   . LEU   A 1 261 ? -22.62457 0.99142   11.86241  1.000 6.17990  ? 240 LEU   A C   1 
ATOM   1844 O O   . LEU   A 1 261 ? -23.31311 1.95091   12.22665  1.000 7.84316  ? 240 LEU   A O   1 
ATOM   1845 C CB  . LEU   A 1 261 ? -20.34982 1.66769   12.67892  1.000 8.72985  ? 240 LEU   A CB  1 
ATOM   1846 C CG  . LEU   A 1 261 ? -20.18371 0.62269   13.78696  1.000 11.04702 ? 240 LEU   A CG  1 
ATOM   1847 C CD1 . LEU   A 1 261 ? -18.75172 0.60099   14.27998  1.000 10.27129 ? 240 LEU   A CD1 1 
ATOM   1848 C CD2 . LEU   A 1 261 ? -21.13972 0.88846   14.94466  1.000 6.62448  ? 240 LEU   A CD2 1 
ATOM   1849 N N   . VAL   A 1 262 ? -23.08716 -0.25149  11.78330  1.000 7.21544  ? 241 VAL   A N   1 
ATOM   1850 C CA  . VAL   A 1 262 ? -24.48279 -0.57393  12.06476  1.000 7.09757  ? 241 VAL   A CA  1 
ATOM   1851 C C   . VAL   A 1 262 ? -24.70598 -0.53510  13.57188  1.000 6.09027  ? 241 VAL   A C   1 
ATOM   1852 O O   . VAL   A 1 262 ? -24.01032 -1.23795  14.32021  1.000 7.09019  ? 241 VAL   A O   1 
ATOM   1853 C CB  . VAL   A 1 262 ? -24.87049 -1.93972  11.48028  1.000 8.52194  ? 241 VAL   A CB  1 
ATOM   1854 C CG1 . VAL   A 1 262 ? -26.34317 -2.21815  11.73912  1.000 9.47801  ? 241 VAL   A CG1 1 
ATOM   1855 C CG2 . VAL   A 1 262 ? -24.57053 -1.97956  9.98775   1.000 11.30792 ? 241 VAL   A CG2 1 
ATOM   1856 N N   . PRO   A 1 263 ? -25.64974 0.26822   14.05671  1.000 7.32987  ? 242 PRO   A N   1 
ATOM   1857 C CA  . PRO   A 1 263 ? -25.85589 0.37276   15.50485  1.000 7.81194  ? 242 PRO   A CA  1 
ATOM   1858 C C   . PRO   A 1 263 ? -26.19896 -0.97154  16.13215  1.000 9.83924  ? 242 PRO   A C   1 
ATOM   1859 O O   . PRO   A 1 263 ? -26.97082 -1.75932  15.58014  1.000 8.90943  ? 242 PRO   A O   1 
ATOM   1860 C CB  . PRO   A 1 263 ? -27.02541 1.35635   15.61508  1.000 9.29755  ? 242 PRO   A CB  1 
ATOM   1861 C CG  . PRO   A 1 263 ? -26.86452 2.23133   14.41217  1.000 9.77967  ? 242 PRO   A CG  1 
ATOM   1862 C CD  . PRO   A 1 263 ? -26.43122 1.27950   13.32084  1.000 9.24200  ? 242 PRO   A CD  1 
ATOM   1863 N N   . ASN   A 1 264 ? -25.59198 -1.22882  17.29249  1.000 7.83971  ? 243 ASN   A N   1 
ATOM   1864 C CA  . ASN   A 1 264 ? -25.99133 -2.31603  18.18794  1.000 9.57185  ? 243 ASN   A CA  1 
ATOM   1865 C C   . ASN   A 1 264 ? -25.82436 -3.69134  17.54233  1.000 11.45107 ? 243 ASN   A C   1 
ATOM   1866 O O   . ASN   A 1 264 ? -26.70608 -4.55092  17.61469  1.000 11.51855 ? 243 ASN   A O   1 
ATOM   1867 C CB  . ASN   A 1 264 ? -27.42483 -2.09915  18.67313  1.000 11.85314 ? 243 ASN   A CB  1 
ATOM   1868 C CG  . ASN   A 1 264 ? -27.61625 -0.72650  19.28336  1.000 8.73389  ? 243 ASN   A CG  1 
ATOM   1869 O OD1 . ASN   A 1 264 ? -26.94707 -0.37479  20.25269  1.000 9.52744  ? 243 ASN   A OD1 1 
ATOM   1870 N ND2 . ASN   A 1 264 ? -28.49688 0.07356   18.69146  1.000 7.87125  ? 243 ASN   A ND2 1 
ATOM   1871 N N   . THR   A 1 265 ? -24.65930 -3.90757  16.92742  1.000 8.30207  ? 244 THR   A N   1 
ATOM   1872 C CA  . THR   A 1 265 ? -24.33164 -5.18576  16.30546  1.000 10.20412 ? 244 THR   A CA  1 
ATOM   1873 C C   . THR   A 1 265 ? -22.94190 -5.65994  16.71349  1.000 10.32814 ? 244 THR   A C   1 
ATOM   1874 O O   . THR   A 1 265 ? -22.29412 -6.40523  15.97324  1.000 10.68993 ? 244 THR   A O   1 
ATOM   1875 C CB  . THR   A 1 265 ? -24.43197 -5.09609  14.78292  1.000 9.30508  ? 244 THR   A CB  1 
ATOM   1876 O OG1 . THR   A 1 265 ? -23.66932 -3.97471  14.31921  1.000 8.67431  ? 244 THR   A OG1 1 
ATOM   1877 C CG2 . THR   A 1 265 ? -25.88109 -4.93512  14.35325  1.000 10.29687 ? 244 THR   A CG2 1 
ATOM   1878 N N   . VAL   A 1 266 ? -22.48050 -5.24821  17.89720  1.000 8.80838  ? 245 VAL   A N   1 
ATOM   1879 C CA  . VAL   A 1 266 ? -21.12862 -5.58708  18.33588  1.000 13.26881 ? 245 VAL   A CA  1 
ATOM   1880 C C   . VAL   A 1 266 ? -20.96546 -7.09711  18.45656  1.000 13.57944 ? 245 VAL   A C   1 
ATOM   1881 O O   . VAL   A 1 266 ? -19.93194 -7.65882  18.07233  1.000 13.82170 ? 245 VAL   A O   1 
ATOM   1882 C CB  . VAL   A 1 266 ? -20.80858 -4.87992  19.66724  1.000 14.19178 ? 245 VAL   A CB  1 
ATOM   1883 C CG1 . VAL   A 1 266 ? -19.58223 -5.50361  20.32474  1.000 17.00798 ? 245 VAL   A CG1 1 
ATOM   1884 C CG2 . VAL   A 1 266 ? -20.61614 -3.38774  19.44875  1.000 10.99116 ? 245 VAL   A CG2 1 
ATOM   1885 N N   . GLU   A 1 267 ? -21.98526 -7.77799  18.98328  1.000 13.74526 ? 246 GLU   A N   1 
ATOM   1886 C CA  . GLU   A 1 267 ? -21.89200 -9.20250  19.27677  1.000 19.32015 ? 246 GLU   A CA  1 
ATOM   1887 C C   . GLU   A 1 267 ? -21.96802 -10.08349 18.03598  1.000 14.66617 ? 246 GLU   A C   1 
ATOM   1888 O O   . GLU   A 1 267 ? -21.80870 -11.30163 18.15950  1.000 17.88472 ? 246 GLU   A O   1 
ATOM   1889 C CB  . GLU   A 1 267 ? -22.99945 -9.60696  20.25183  1.000 20.83576 ? 246 GLU   A CB  1 
ATOM   1890 C CG  . GLU   A 1 267 ? -22.59939 -9.53535  21.72115  1.000 36.83141 ? 246 GLU   A CG  1 
ATOM   1891 C CD  . GLU   A 1 267 ? -22.36310 -8.11502  22.20259  1.000 38.80806 ? 246 GLU   A CD  1 
ATOM   1892 O OE1 . GLU   A 1 267 ? -23.23372 -7.25063  21.96014  1.000 41.85869 ? 246 GLU   A OE1 1 
ATOM   1893 O OE2 . GLU   A 1 267 ? -21.30872 -7.86297  22.82641  1.000 39.60397 ? 246 GLU   A OE2 1 
ATOM   1894 N N   . LEU   A 1 268 ? -22.21886 -9.51705  16.85580  1.000 15.36597 ? 247 LEU   A N   1 
ATOM   1895 C CA  . LEU   A 1 268 ? -22.40911 -10.35206 15.67394  1.000 10.72579 ? 247 LEU   A CA  1 
ATOM   1896 C C   . LEU   A 1 268 ? -21.09168 -10.78775 15.03963  1.000 14.89482 ? 247 LEU   A C   1 
ATOM   1897 O O   . LEU   A 1 268 ? -21.02287 -11.87970 14.46437  1.000 13.14101 ? 247 LEU   A O   1 
ATOM   1898 C CB  . LEU   A 1 268 ? -23.27513 -9.62005  14.64897  1.000 12.48910 ? 247 LEU   A CB  1 
ATOM   1899 C CG  . LEU   A 1 268 ? -24.67232 -9.24092  15.14286  1.000 15.17131 ? 247 LEU   A CG  1 
ATOM   1900 C CD1 . LEU   A 1 268 ? -25.51315 -8.69138  14.00720  1.000 15.92425 ? 247 LEU   A CD1 1 
ATOM   1901 C CD2 . LEU   A 1 268 ? -25.35864 -10.43250 15.80159  1.000 20.97442 ? 247 LEU   A CD2 1 
ATOM   1902 N N   . MET   A 1 269 ? -20.04773 -9.96415  15.12179  1.000 12.81697 ? 248 MET   A N   1 
ATOM   1903 C CA  . MET   A 1 269 ? -18.75984 -10.30207 14.52939  1.000 14.63154 ? 248 MET   A CA  1 
ATOM   1904 C C   . MET   A 1 269 ? -17.62986 -9.71106  15.35863  1.000 11.19810 ? 248 MET   A C   1 
ATOM   1905 O O   . MET   A 1 269 ? -17.75166 -8.60295  15.88622  1.000 13.88011 ? 248 MET   A O   1 
ATOM   1906 C CB  . MET   A 1 269 ? -18.63918 -9.79284  13.09036  1.000 14.60785 ? 248 MET   A CB  1 
ATOM   1907 C CG  . MET   A 1 269 ? -17.49008 -10.42017 12.31939  1.000 17.17465 ? 248 MET   A CG  1 
ATOM   1908 S SD  . MET   A 1 269 ? -17.43111 -9.94668  10.58378  1.000 22.65239 ? 248 MET   A SD  1 
ATOM   1909 C CE  . MET   A 1 269 ? -19.15686 -9.95181  10.16493  1.000 18.37315 ? 248 MET   A CE  1 
ATOM   1910 N N   . GLY   A 1 270 ? -16.53319 -10.44954 15.45121  1.000 11.63380 ? 249 GLY   A N   1 
ATOM   1911 C CA  . GLY   A 1 270 ? -15.35519 -9.97124  16.14193  1.000 11.74450 ? 249 GLY   A CA  1 
ATOM   1912 C C   . GLY   A 1 270 ? -14.45125 -11.12995 16.51491  1.000 15.58717 ? 249 GLY   A C   1 
ATOM   1913 O O   . GLY   A 1 270 ? -14.69137 -12.27775 16.14080  1.000 15.67446 ? 249 GLY   A O   1 
ATOM   1914 N N   . LEU   A 1 271 ? -13.39875 -10.79345 17.25842  1.000 14.66513 ? 250 LEU   A N   1 
ATOM   1915 C CA  . LEU   A 1 271 ? -12.45001 -11.77212 17.77791  1.000 16.00990 ? 250 LEU   A CA  1 
ATOM   1916 C C   . LEU   A 1 271 ? -12.30332 -11.55735 19.27501  1.000 19.18361 ? 250 LEU   A C   1 
ATOM   1917 O O   . LEU   A 1 271 ? -11.94181 -10.46058 19.71340  1.000 17.00431 ? 250 LEU   A O   1 
ATOM   1918 C CB  . LEU   A 1 271 ? -11.09203 -11.65705 17.08004  1.000 13.99581 ? 250 LEU   A CB  1 
ATOM   1919 C CG  . LEU   A 1 271 ? -10.17219 -12.86843 17.22853  1.000 17.06648 ? 250 LEU   A CG  1 
ATOM   1920 C CD1 . LEU   A 1 271 ? -10.46646 -13.90346 16.15699  1.000 22.27151 ? 250 LEU   A CD1 1 
ATOM   1921 C CD2 . LEU   A 1 271 ? -8.71737  -12.43422 17.16868  1.000 18.50581 ? 250 LEU   A CD2 1 
ATOM   1922 N N   . ASP   A 1 272 ? -12.57112 -12.60119 20.05283  1.000 14.60883 ? 251 ASP   A N   1 
ATOM   1923 C CA  . ASP   A 1 272 ? -12.55008 -12.52522 21.50510  1.000 24.61798 ? 251 ASP   A CA  1 
ATOM   1924 C C   . ASP   A 1 272 ? -11.36303 -13.30004 22.05754  1.000 28.91357 ? 251 ASP   A C   1 
ATOM   1925 O O   . ASP   A 1 272 ? -10.99369 -14.35392 21.52995  1.000 23.21887 ? 251 ASP   A O   1 
ATOM   1926 C CB  . ASP   A 1 272 ? -13.84572 -13.07871 22.10617  1.000 24.16355 ? 251 ASP   A CB  1 
ATOM   1927 C CG  . ASP   A 1 272 ? -15.02702 -12.15583 21.89532  1.000 23.68910 ? 251 ASP   A CG  1 
ATOM   1928 O OD1 . ASP   A 1 272 ? -14.80552 -10.98180 21.52937  1.000 23.49661 ? 251 ASP   A OD1 1 
ATOM   1929 O OD2 . ASP   A 1 272 ? -16.17554 -12.60195 22.10094  1.000 23.45294 ? 251 ASP   A OD2 1 
ATOM   1930 N N   . VAL   A 1 273 ? -10.76622 -12.76973 23.11600  1.000 29.85017 ? 252 VAL   A N   1 
ATOM   1931 C CA  . VAL   A 1 273 ? -9.75453  -13.49149 23.87446  1.000 32.90850 ? 252 VAL   A CA  1 
ATOM   1932 C C   . VAL   A 1 273 ? -10.46347 -14.30980 24.94333  1.000 34.63834 ? 252 VAL   A C   1 
ATOM   1933 O O   . VAL   A 1 273 ? -11.36043 -13.80620 25.63088  1.000 30.19139 ? 252 VAL   A O   1 
ATOM   1934 C CB  . VAL   A 1 273 ? -8.73329  -12.52522 24.49676  1.000 34.83817 ? 252 VAL   A CB  1 
ATOM   1935 C CG1 . VAL   A 1 273 ? -7.68393  -13.29684 25.28734  1.000 30.84424 ? 252 VAL   A CG1 1 
ATOM   1936 C CG2 . VAL   A 1 273 ? -8.07585  -11.68133 23.41371  1.000 33.56303 ? 252 VAL   A CG2 1 
ATOM   1937 N N   . VAL   A 1 274 ? -10.08014 -15.57537 25.06968  1.000 34.84287 ? 253 VAL   A N   1 
ATOM   1938 C CA  . VAL   A 1 274 ? -10.69200 -16.46118 26.04807  1.000 32.75623 ? 253 VAL   A CA  1 
ATOM   1939 C C   . VAL   A 1 274 ? -9.66543  -17.46908 26.54868  1.000 40.01875 ? 253 VAL   A C   1 
ATOM   1940 O O   . VAL   A 1 274 ? -9.82827  -18.06172 27.61623  1.000 38.78744 ? 253 VAL   A O   1 
ATOM   1941 C CB  . VAL   A 1 274 ? -11.92115 -17.17460 25.45759  1.000 36.36721 ? 253 VAL   A CB  1 
ATOM   1942 C CG1 . VAL   A 1 274 ? -11.48473 -18.31448 24.54943  1.000 39.21734 ? 253 VAL   A CG1 1 
ATOM   1943 C CG2 . VAL   A 1 274 ? -12.83230 -17.67990 26.56853  1.000 43.48604 ? 253 VAL   A CG2 1 
ATOM   1944 N N   . GLY   A 1 277 ? -7.39154  -19.34182 24.41283  1.000 36.21129 ? 256 GLY   A N   1 
ATOM   1945 C CA  . GLY   A 1 277 ? -6.89252  -18.60157 23.26913  1.000 34.32760 ? 256 GLY   A CA  1 
ATOM   1946 C C   . GLY   A 1 277 ? -7.91052  -17.63971 22.68860  1.000 33.68964 ? 256 GLY   A C   1 
ATOM   1947 O O   . GLY   A 1 277 ? -8.53448  -16.86823 23.41716  1.000 30.78805 ? 256 GLY   A O   1 
ATOM   1948 N N   . PHE   A 1 278 ? -8.07214  -17.67981 21.37063  1.000 31.93722 ? 257 PHE   A N   1 
ATOM   1949 C CA  . PHE   A 1 278 ? -9.04208  -16.84139 20.68587  1.000 23.32907 ? 257 PHE   A CA  1 
ATOM   1950 C C   . PHE   A 1 278 ? -10.34625 -17.59638 20.46392  1.000 26.96360 ? 257 PHE   A C   1 
ATOM   1951 O O   . PHE   A 1 278 ? -10.40443 -18.82605 20.52802  1.000 25.51589 ? 257 PHE   A O   1 
ATOM   1952 C CB  . PHE   A 1 278 ? -8.50696  -16.36931 19.33185  1.000 23.03425 ? 257 PHE   A CB  1 
ATOM   1953 C CG  . PHE   A 1 278 ? -7.25077  -15.55138 19.41344  1.000 33.29775 ? 257 PHE   A CG  1 
ATOM   1954 C CD1 . PHE   A 1 278 ? -7.22272  -14.36472 20.12731  1.000 33.75607 ? 257 PHE   A CD1 1 
ATOM   1955 C CD2 . PHE   A 1 278 ? -6.10372  -15.95627 18.74944  1.000 35.90042 ? 257 PHE   A CD2 1 
ATOM   1956 C CE1 . PHE   A 1 278 ? -6.06922  -13.60667 20.19149  1.000 39.03887 ? 257 PHE   A CE1 1 
ATOM   1957 C CE2 . PHE   A 1 278 ? -4.94894  -15.20283 18.80988  1.000 38.29259 ? 257 PHE   A CE2 1 
ATOM   1958 C CZ  . PHE   A 1 278 ? -4.93103  -14.02755 19.53333  1.000 33.90794 ? 257 PHE   A CZ  1 
ATOM   1959 N N   . ARG   A 1 279 ? -11.40583 -16.83670 20.20391  1.000 19.98390 ? 258 ARG   A N   1 
ATOM   1960 C CA  . ARG   A 1 279 ? -12.58415 -17.39507 19.56011  1.000 23.32823 ? 258 ARG   A CA  1 
ATOM   1961 C C   . ARG   A 1 279 ? -13.07236 -16.40961 18.51383  1.000 22.34399 ? 258 ARG   A C   1 
ATOM   1962 O O   . ARG   A 1 279 ? -13.29874 -15.23418 18.81840  1.000 20.31691 ? 258 ARG   A O   1 
ATOM   1963 C CB  . ARG   A 1 279 ? -13.70985 -17.71081 20.54957  1.000 28.73243 ? 258 ARG   A CB  1 
ATOM   1964 C CG  . ARG   A 1 279 ? -14.86426 -18.44108 19.86451  1.000 26.54831 ? 258 ARG   A CG  1 
ATOM   1965 C CD  . ARG   A 1 279 ? -15.97923 -18.84732 20.80887  1.000 26.53310 ? 258 ARG   A CD  1 
ATOM   1966 N NE  . ARG   A 1 279 ? -16.90498 -19.75693 20.14204  1.000 28.81688 ? 258 ARG   A NE  1 
ATOM   1967 C CZ  . ARG   A 1 279 ? -18.20076 -19.84975 20.40461  1.000 31.57765 ? 258 ARG   A CZ  1 
ATOM   1968 N NH1 . ARG   A 1 279 ? -18.78309 -19.06847 21.29909  1.000 31.31840 ? 258 ARG   A NH1 1 
ATOM   1969 N NH2 . ARG   A 1 279 ? -18.93111 -20.74953 19.75093  1.000 27.06105 ? 258 ARG   A NH2 1 
ATOM   1970 N N   . ASN   A 1 280 ? -13.22168 -16.89040 17.28474  1.000 17.34169 ? 259 ASN   A N   1 
ATOM   1971 C CA  . ASN   A 1 280 ? -13.76798 -16.07269 16.21519  1.000 18.50796 ? 259 ASN   A CA  1 
ATOM   1972 C C   . ASN   A 1 280 ? -15.28096 -15.99663 16.35933  1.000 18.60851 ? 259 ASN   A C   1 
ATOM   1973 O O   . ASN   A 1 280 ? -15.95035 -17.02274 16.51869  1.000 21.75406 ? 259 ASN   A O   1 
ATOM   1974 C CB  . ASN   A 1 280 ? -13.39561 -16.65364 14.85444  1.000 19.19668 ? 259 ASN   A CB  1 
ATOM   1975 C CG  . ASN   A 1 280 ? -13.95421 -15.84257 13.71090  1.000 22.66876 ? 259 ASN   A CG  1 
ATOM   1976 O OD1 . ASN   A 1 280 ? -13.64970 -14.65750 13.56776  1.000 26.86194 ? 259 ASN   A OD1 1 
ATOM   1977 N ND2 . ASN   A 1 280 ? -14.80289 -16.46739 12.90381  1.000 22.70676 ? 259 ASN   A ND2 1 
ATOM   1978 N N   . ILE   A 1 281 ? -15.81905 -14.78406 16.30417  1.000 16.44784 ? 260 ILE   A N   1 
ATOM   1979 C CA  . ILE   A 1 281 ? -17.25333 -14.55930 16.42208  1.000 16.33271 ? 260 ILE   A CA  1 
ATOM   1980 C C   . ILE   A 1 281 ? -17.80550 -14.24166 15.04089  1.000 16.36929 ? 260 ILE   A C   1 
ATOM   1981 O O   . ILE   A 1 281 ? -17.41116 -13.25002 14.41656  1.000 15.30976 ? 260 ILE   A O   1 
ATOM   1982 C CB  . ILE   A 1 281 ? -17.56888 -13.43151 17.41579  1.000 16.36801 ? 260 ILE   A CB  1 
ATOM   1983 C CG1 . ILE   A 1 281 ? -16.84331 -13.67196 18.74220  1.000 17.41326 ? 260 ILE   A CG1 1 
ATOM   1984 C CG2 . ILE   A 1 281 ? -19.07524 -13.31468 17.62144  1.000 16.96166 ? 260 ILE   A CG2 1 
ATOM   1985 C CD1 . ILE   A 1 281 ? -17.43958 -14.79110 19.56867  1.000 21.56829 ? 260 ILE   A CD1 1 
ATOM   1986 N N   . LEU   A 1 282 ? -18.72229 -15.08379 14.56623  1.000 15.56914 ? 261 LEU   A N   1 
ATOM   1987 C CA  . LEU   A 1 282 ? -19.39255 -14.86404 13.28456  1.000 19.86038 ? 261 LEU   A CA  1 
ATOM   1988 C C   . LEU   A 1 282 ? -20.80427 -15.43855 13.42005  1.000 17.64960 ? 261 LEU   A C   1 
ATOM   1989 O O   . LEU   A 1 282 ? -21.02618 -16.63086 13.19991  1.000 19.13287 ? 261 LEU   A O   1 
ATOM   1990 C CB  . LEU   A 1 282 ? -18.62321 -15.50656 12.14061  1.000 15.17025 ? 261 LEU   A CB  1 
ATOM   1991 C CG  . LEU   A 1 282 ? -19.17875 -15.31667 10.73062  1.000 23.07313 ? 261 LEU   A CG  1 
ATOM   1992 C CD1 . LEU   A 1 282 ? -19.03837 -13.86577 10.29607  1.000 24.93252 ? 261 LEU   A CD1 1 
ATOM   1993 C CD2 . LEU   A 1 282 ? -18.45784 -16.23898 9.76137   1.000 26.43593 ? 261 LEU   A CD2 1 
ATOM   1994 N N   . ARG   A 1 283 ? -21.74906 -14.57384 13.78568  1.000 19.47293 ? 262 ARG   A N   1 
ATOM   1995 C CA  . ARG   A 1 283 ? -23.11253 -15.00786 14.04663  1.000 19.15716 ? 262 ARG   A CA  1 
ATOM   1996 C C   . ARG   A 1 283 ? -23.89059 -15.17046 12.74084  1.000 21.83990 ? 262 ARG   A C   1 
ATOM   1997 O O   . ARG   A 1 283 ? -23.60015 -14.49694 11.74829  1.000 18.93032 ? 262 ARG   A O   1 
ATOM   1998 C CB  . ARG   A 1 283 ? -23.82469 -14.00630 14.95137  1.000 17.61626 ? 262 ARG   A CB  1 
ATOM   1999 C CG  . ARG   A 1 283 ? -23.24539 -13.90647 16.35649  1.000 16.83182 ? 262 ARG   A CG  1 
ATOM   2000 C CD  . ARG   A 1 283 ? -23.33783 -15.22702 17.11041  1.000 28.51637 ? 262 ARG   A CD  1 
ATOM   2001 N NE  . ARG   A 1 283 ? -22.54729 -15.20523 18.33657  1.000 30.15164 ? 262 ARG   A NE  1 
ATOM   2002 C CZ  . ARG   A 1 283 ? -22.36664 -16.24905 19.13484  1.000 29.93005 ? 262 ARG   A CZ  1 
ATOM   2003 N NH1 . ARG   A 1 283 ? -22.92524 -17.42067 18.87915  1.000 33.07697 ? 262 ARG   A NH1 1 
ATOM   2004 N NH2 . ARG   A 1 283 ? -21.60475 -16.11411 20.21673  1.000 31.29748 ? 262 ARG   A NH2 1 
ATOM   2005 N N   . PRO   A 1 284 ? -24.88441 -16.06421 12.71634  1.000 24.79809 ? 263 PRO   A N   1 
ATOM   2006 C CA  . PRO   A 1 284 ? -25.68129 -16.23172 11.48772  1.000 26.70791 ? 263 PRO   A CA  1 
ATOM   2007 C C   . PRO   A 1 284 ? -26.41365 -14.97002 11.06531  1.000 19.07651 ? 263 PRO   A C   1 
ATOM   2008 O O   . PRO   A 1 284 ? -26.69166 -14.79571 9.87225   1.000 23.22363 ? 263 PRO   A O   1 
ATOM   2009 C CB  . PRO   A 1 284 ? -26.66011 -17.36052 11.84906  1.000 24.62213 ? 263 PRO   A CB  1 
ATOM   2010 C CG  . PRO   A 1 284 ? -26.63425 -17.45351 13.34345  1.000 26.83925 ? 263 PRO   A CG  1 
ATOM   2011 C CD  . PRO   A 1 284 ? -25.26786 -17.02326 13.76554  1.000 21.05341 ? 263 PRO   A CD  1 
ATOM   2012 N N   . GLU   A 1 285 ? -26.72589 -14.07901 12.00804  1.000 26.49292 ? 264 GLU   A N   1 
ATOM   2013 C CA  . GLU   A 1 285 ? -27.43299 -12.83470 11.72365  1.000 18.04052 ? 264 GLU   A CA  1 
ATOM   2014 C C   . GLU   A 1 285 ? -26.56882 -11.80451 11.00997  1.000 21.70702 ? 264 GLU   A C   1 
ATOM   2015 O O   . GLU   A 1 285 ? -27.05490 -10.69777 10.74730  1.000 20.03205 ? 264 GLU   A O   1 
ATOM   2016 C CB  . GLU   A 1 285 ? -27.96509 -12.22551 13.02374  1.000 16.88870 ? 264 GLU   A CB  1 
ATOM   2017 C CG  . GLU   A 1 285 ? -29.05657 -13.03771 13.70565  1.000 26.98101 ? 264 GLU   A CG  1 
ATOM   2018 C CD  . GLU   A 1 285 ? -28.50354 -14.14987 14.57898  1.000 26.32561 ? 264 GLU   A CD  1 
ATOM   2019 O OE1 . GLU   A 1 285 ? -27.26725 -14.23147 14.73795  1.000 22.72163 ? 264 GLU   A OE1 1 
ATOM   2020 O OE2 . GLU   A 1 285 ? -29.30705 -14.94850 15.10302  1.000 40.31224 ? 264 GLU   A OE2 1 
ATOM   2021 N N   . VAL   A 1 286 ? -25.31013 -12.12974 10.70669  1.000 18.34824 ? 265 VAL   A N   1 
ATOM   2022 C CA  . VAL   A 1 286 ? -24.40451 -11.15070 10.11018  1.000 18.66427 ? 265 VAL   A CA  1 
ATOM   2023 C C   . VAL   A 1 286 ? -24.92612 -10.69093 8.75329   1.000 22.64412 ? 265 VAL   A C   1 
ATOM   2024 O O   . VAL   A 1 286 ? -25.02830 -9.48764  8.48490   1.000 19.77546 ? 265 VAL   A O   1 
ATOM   2025 C CB  . VAL   A 1 286 ? -22.98559 -11.73697 10.00200  1.000 21.96107 ? 265 VAL   A CB  1 
ATOM   2026 C CG1 . VAL   A 1 286 ? -22.21948 -11.07568 8.86990   1.000 25.32741 ? 265 VAL   A CG1 1 
ATOM   2027 C CG2 . VAL   A 1 286 ? -22.25050 -11.57754 11.32393  1.000 19.59567 ? 265 VAL   A CG2 1 
ATOM   2028 N N   . SER   A 1 287 ? -25.28498 -11.64210 7.88500   1.000 21.28027 ? 266 SER   A N   1 
ATOM   2029 C CA  . SER   A 1 287 ? -25.67417 -11.28502 6.52322   1.000 28.92790 ? 266 SER   A CA  1 
ATOM   2030 C C   . SER   A 1 287 ? -26.92172 -10.41060 6.51577   1.000 24.09125 ? 266 SER   A C   1 
ATOM   2031 O O   . SER   A 1 287 ? -27.01372 -9.45376  5.73685   1.000 25.11366 ? 266 SER   A O   1 
ATOM   2032 C CB  . SER   A 1 287 ? -25.89242 -12.54756 5.68718   1.000 24.92194 ? 266 SER   A CB  1 
ATOM   2033 O OG  . SER   A 1 287 ? -27.05477 -13.24437 6.10226   1.000 40.30715 ? 266 SER   A OG  1 
ATOM   2034 N N   . ASP   A 1 288 ? -27.89110 -10.72093 7.37960   1.000 27.98633 ? 267 ASP   A N   1 
ATOM   2035 C CA  . ASP   A 1 288 ? -29.09742 -9.90390  7.46333   1.000 22.56039 ? 267 ASP   A CA  1 
ATOM   2036 C C   . ASP   A 1 288 ? -28.78853 -8.51332  8.00608   1.000 21.96843 ? 267 ASP   A C   1 
ATOM   2037 O O   . ASP   A 1 288 ? -29.37334 -7.52069  7.55687   1.000 26.77649 ? 267 ASP   A O   1 
ATOM   2038 C CB  . ASP   A 1 288 ? -30.14224 -10.60086 8.33296   1.000 35.63026 ? 267 ASP   A CB  1 
ATOM   2039 C CG  . ASP   A 1 288 ? -30.77455 -11.79474 7.64095   1.000 35.12606 ? 267 ASP   A CG  1 
ATOM   2040 O OD1 . ASP   A 1 288 ? -30.86921 -11.78185 6.39475   1.000 29.53844 ? 267 ASP   A OD1 1 
ATOM   2041 O OD2 . ASP   A 1 288 ? -31.18467 -12.74236 8.34539   1.000 37.28244 ? 267 ASP   A OD2 1 
ATOM   2042 N N   . ALA   A 1 289 ? -27.87457 -8.42047  8.97499   1.000 24.62722 ? 268 ALA   A N   1 
ATOM   2043 C CA  . ALA   A 1 289 ? -27.49814 -7.12216  9.52193   1.000 20.25775 ? 268 ALA   A CA  1 
ATOM   2044 C C   . ALA   A 1 289 ? -26.76715 -6.25381  8.50525   1.000 19.85634 ? 268 ALA   A C   1 
ATOM   2045 O O   . ALA   A 1 289 ? -26.78585 -5.02535  8.63344   1.000 20.45957 ? 268 ALA   A O   1 
ATOM   2046 C CB  . ALA   A 1 289 ? -26.63269 -7.30772  10.76898  1.000 22.62409 ? 268 ALA   A CB  1 
ATOM   2047 N N   . LEU   A 1 290 ? -26.12687 -6.86175  7.50188   1.000 14.15949 ? 269 LEU   A N   1 
ATOM   2048 C CA  . LEU   A 1 290 ? -25.45676 -6.08043  6.46665   1.000 21.22650 ? 269 LEU   A CA  1 
ATOM   2049 C C   . LEU   A 1 290 ? -26.43975 -5.22975  5.67457   1.000 20.71679 ? 269 LEU   A C   1 
ATOM   2050 O O   . LEU   A 1 290 ? -26.08706 -4.13102  5.22991   1.000 21.61900 ? 269 LEU   A O   1 
ATOM   2051 C CB  . LEU   A 1 290 ? -24.68434 -7.00211  5.52063   1.000 25.05489 ? 269 LEU   A CB  1 
ATOM   2052 C CG  . LEU   A 1 290 ? -23.58351 -7.88533  6.10868   1.000 33.88812 ? 269 LEU   A CG  1 
ATOM   2053 C CD1 . LEU   A 1 290 ? -22.81218 -8.56886  4.99227   1.000 31.25611 ? 269 LEU   A CD1 1 
ATOM   2054 C CD2 . LEU   A 1 290 ? -22.64313 -7.07139  6.98861   1.000 26.51740 ? 269 LEU   A CD2 1 
ATOM   2055 N N   . LYS   A 1 291 ? -27.67181 -5.71677  5.48659   1.000 22.07105 ? 270 LYS   A N   1 
ATOM   2056 C CA  . LYS   A 1 291 ? -28.65485 -4.97883  4.69751   1.000 22.43934 ? 270 LYS   A CA  1 
ATOM   2057 C C   . LYS   A 1 291 ? -28.96136 -3.61539  5.30089   1.000 23.78241 ? 270 LYS   A C   1 
ATOM   2058 O O   . LYS   A 1 291 ? -29.34732 -2.68978  4.57792   1.000 29.46924 ? 270 LYS   A O   1 
ATOM   2059 C CB  . LYS   A 1 291 ? -29.94785 -5.78525  4.56699   1.000 18.28115 ? 270 LYS   A CB  1 
ATOM   2060 C CG  . LYS   A 1 291 ? -29.78552 -7.14863  3.92637   1.000 24.41734 ? 270 LYS   A CG  1 
ATOM   2061 C CD  . LYS   A 1 291 ? -31.12957 -7.84963  3.79307   1.000 22.79370 ? 270 LYS   A CD  1 
ATOM   2062 C CE  . LYS   A 1 291 ? -31.04912 -9.29675  4.25880   1.000 35.11939 ? 270 LYS   A CE  1 
ATOM   2063 N NZ  . LYS   A 1 291 ? -31.96425 -10.18983 3.49300   1.000 32.68518 ? 270 LYS   A NZ  1 
ATOM   2064 N N   . GLN   A 1 292 ? -28.80951 -3.47154  6.61726   1.000 15.17976 ? 271 GLN   A N   1 
ATOM   2065 C CA  . GLN   A 1 292 ? -29.08613 -2.19100  7.25241   1.000 19.04054 ? 271 GLN   A CA  1 
ATOM   2066 C C   . GLN   A 1 292 ? -28.02539 -1.14338  6.94273   1.000 21.15905 ? 271 GLN   A C   1 
ATOM   2067 O O   . GLN   A 1 292 ? -28.28819 0.05187   7.10999   1.000 26.25054 ? 271 GLN   A O   1 
ATOM   2068 C CB  . GLN   A 1 292 ? -29.20772 -2.37308  8.76488   1.000 22.40453 ? 271 GLN   A CB  1 
ATOM   2069 C CG  . GLN   A 1 292 ? -29.99076 -3.60301  9.18398   1.000 23.54955 ? 271 GLN   A CG  1 
ATOM   2070 C CD  . GLN   A 1 292 ? -30.10809 -3.71170  10.68647  1.000 17.84506 ? 271 GLN   A CD  1 
ATOM   2071 O OE1 . GLN   A 1 292 ? -29.78005 -2.77275  11.40846  1.000 28.07144 ? 271 GLN   A OE1 1 
ATOM   2072 N NE2 . GLN   A 1 292 ? -30.58800 -4.85281  11.16740  1.000 22.34530 ? 271 GLN   A NE2 1 
ATOM   2073 N N   . GLY   A 1 293 ? -26.84281 -1.55473  6.49534   1.000 16.35471 ? 272 GLY   A N   1 
ATOM   2074 C CA  . GLY   A 1 293 ? -25.76762 -0.60748  6.28213   1.000 23.42242 ? 272 GLY   A CA  1 
ATOM   2075 C C   . GLY   A 1 293 ? -25.31073 -0.45576  4.84474   1.000 14.44963 ? 272 GLY   A C   1 
ATOM   2076 O O   . GLY   A 1 293 ? -24.82798 0.61326   4.46243   1.000 11.14680 ? 272 GLY   A O   1 
ATOM   2077 N N   . LEU   A 1 294 ? -25.47691 -1.50462  4.03519   1.000 14.97382 ? 273 LEU   A N   1 
ATOM   2078 C CA  . LEU   A 1 294 ? -24.87910 -1.52720  2.70216   1.000 14.70681 ? 273 LEU   A CA  1 
ATOM   2079 C C   . LEU   A 1 294 ? -25.43452 -0.41867  1.81406   1.000 13.58362 ? 273 LEU   A C   1 
ATOM   2080 O O   . LEU   A 1 294 ? -24.68164 0.40713   1.28562   1.000 14.07066 ? 273 LEU   A O   1 
ATOM   2081 C CB  . LEU   A 1 294 ? -25.10116 -2.89426  2.05453   1.000 13.07818 ? 273 LEU   A CB  1 
ATOM   2082 C CG  . LEU   A 1 294 ? -24.11514 -3.99437  2.44659   1.000 19.80841 ? 273 LEU   A CG  1 
ATOM   2083 C CD1 . LEU   A 1 294 ? -24.58204 -5.34289  1.92277   1.000 26.78386 ? 273 LEU   A CD1 1 
ATOM   2084 C CD2 . LEU   A 1 294 ? -22.72314 -3.66532  1.92888   1.000 19.83632 ? 273 LEU   A CD2 1 
ATOM   2085 N N   . ARG   A 1 295 ? -26.75234 -0.38828  1.62705   1.000 13.44563 ? 274 ARG   A N   1 
ATOM   2086 C CA  . ARG   A 1 295 ? -27.31408 0.57159   0.68482   1.000 14.22451 ? 274 ARG   A CA  1 
ATOM   2087 C C   . ARG   A 1 295 ? -27.22206 2.00654   1.20546   1.000 15.05413 ? 274 ARG   A C   1 
ATOM   2088 O O   . ARG   A 1 295 ? -26.89403 2.90556   0.42137   1.000 15.77610 ? 274 ARG   A O   1 
ATOM   2089 C CB  . ARG   A 1 295 ? -28.75974 0.20869   0.32463   1.000 21.69914 ? 274 ARG   A CB  1 
ATOM   2090 C CG  . ARG   A 1 295 ? -28.87250 -0.59134  -0.97131  1.000 22.70093 ? 274 ARG   A CG  1 
ATOM   2091 C CD  . ARG   A 1 295 ? -30.29833 -0.65336  -1.49145  1.000 20.91801 ? 274 ARG   A CD  1 
ATOM   2092 N NE  . ARG   A 1 295 ? -31.07434 -1.72658  -0.88205  1.000 19.46701 ? 274 ARG   A NE  1 
ATOM   2093 C CZ  . ARG   A 1 295 ? -32.29839 -2.06693  -1.26078  1.000 13.55485 ? 274 ARG   A CZ  1 
ATOM   2094 N NH1 . ARG   A 1 295 ? -32.91441 -1.43979  -2.24935  1.000 20.77763 ? 274 ARG   A NH1 1 
ATOM   2095 N NH2 . ARG   A 1 295 ? -32.91784 -3.06380  -0.63557  1.000 16.49472 ? 274 ARG   A NH2 1 
ATOM   2096 N N   . PRO   A 1 296 ? -27.50559 2.28497   2.48894   1.000 14.50670 ? 275 PRO   A N   1 
ATOM   2097 C CA  . PRO   A 1 296 ? -27.26624 3.65665   2.98029   1.000 16.00223 ? 275 PRO   A CA  1 
ATOM   2098 C C   . PRO   A 1 296 ? -25.83396 4.12139   2.77345   1.000 14.60640 ? 275 PRO   A C   1 
ATOM   2099 O O   . PRO   A 1 296 ? -25.60003 5.29328   2.44999   1.000 15.58489 ? 275 PRO   A O   1 
ATOM   2100 C CB  . PRO   A 1 296 ? -27.61440 3.57533   4.47553   1.000 24.64887 ? 275 PRO   A CB  1 
ATOM   2101 C CG  . PRO   A 1 296 ? -28.12910 2.19493   4.72497   1.000 27.82681 ? 275 PRO   A CG  1 
ATOM   2102 C CD  . PRO   A 1 296 ? -28.36368 1.52715   3.41474   1.000 16.66513 ? 275 PRO   A CD  1 
ATOM   2103 N N   . LEU   A 1 297 ? -24.86654 3.22062   2.94095   1.000 6.55438  ? 276 LEU   A N   1 
ATOM   2104 C CA  . LEU   A 1 297 ? -23.46453 3.57394   2.75253   1.000 11.56647 ? 276 LEU   A CA  1 
ATOM   2105 C C   . LEU   A 1 297 ? -23.14595 3.82502   1.28259   1.000 9.94849  ? 276 LEU   A C   1 
ATOM   2106 O O   . LEU   A 1 297 ? -22.65118 4.89695   0.91444   1.000 12.75079 ? 276 LEU   A O   1 
ATOM   2107 C CB  . LEU   A 1 297 ? -22.57966 2.45956   3.31084   1.000 10.02519 ? 276 LEU   A CB  1 
ATOM   2108 C CG  . LEU   A 1 297 ? -21.08385 2.51490   3.00676   1.000 7.55801  ? 276 LEU   A CG  1 
ATOM   2109 C CD1 . LEU   A 1 297 ? -20.47725 3.78917   3.56421   1.000 9.50590  ? 276 LEU   A CD1 1 
ATOM   2110 C CD2 . LEU   A 1 297 ? -20.40014 1.29295   3.59066   1.000 8.66666  ? 276 LEU   A CD2 1 
ATOM   2111 N N   . ILE   A 1 298 ? -23.41090 2.83535   0.42812   1.000 8.89766  ? 277 ILE   A N   1 
ATOM   2112 C CA  . ILE   A 1 298 ? -22.93808 2.89864   -0.95304  1.000 9.66969  ? 277 ILE   A CA  1 
ATOM   2113 C C   . ILE   A 1 298 ? -23.72414 3.92779   -1.75629  1.000 9.51383  ? 277 ILE   A C   1 
ATOM   2114 O O   . ILE   A 1 298 ? -23.14468 4.73561   -2.49056  1.000 12.00146 ? 277 ILE   A O   1 
ATOM   2115 C CB  . ILE   A 1 298 ? -22.98791 1.50614   -1.60481  1.000 9.69211  ? 277 ILE   A CB  1 
ATOM   2116 C CG1 . ILE   A 1 298 ? -21.94856 0.59026   -0.94783  1.000 15.27198 ? 277 ILE   A CG1 1 
ATOM   2117 C CG2 . ILE   A 1 298 ? -22.76959 1.61618   -3.10801  1.000 8.36555  ? 277 ILE   A CG2 1 
ATOM   2118 C CD1 . ILE   A 1 298 ? -22.14536 -0.88217  -1.21685  1.000 14.34367 ? 277 ILE   A CD1 1 
ATOM   2119 N N   . ASN   A 1 299 ? -25.05181 3.91508   -1.64135  1.000 12.85555 ? 278 ASN   A N   1 
ATOM   2120 C CA  . ASN   A 1 299 ? -25.84835 4.85347   -2.42632  1.000 12.79977 ? 278 ASN   A CA  1 
ATOM   2121 C C   . ASN   A 1 299 ? -25.58406 6.29203   -1.99542  1.000 13.88407 ? 278 ASN   A C   1 
ATOM   2122 O O   . ASN   A 1 299 ? -25.58077 7.20729   -2.82713  1.000 13.44818 ? 278 ASN   A O   1 
ATOM   2123 C CB  . ASN   A 1 299 ? -27.32955 4.50863   -2.30712  1.000 17.77714 ? 278 ASN   A CB  1 
ATOM   2124 C CG  . ASN   A 1 299 ? -27.72654 3.34334   -3.19044  1.000 23.84807 ? 278 ASN   A CG  1 
ATOM   2125 O OD1 . ASN   A 1 299 ? -27.09122 3.07025   -4.20978  1.000 23.92453 ? 278 ASN   A OD1 1 
ATOM   2126 N ND2 . ASN   A 1 299 ? -28.77822 2.64149   -2.79559  1.000 21.35918 ? 278 ASN   A ND2 1 
ATOM   2127 N N   . GLY   A 1 300 ? -25.35109 6.51070   -0.70012  1.000 10.11670 ? 279 GLY   A N   1 
ATOM   2128 C CA  . GLY   A 1 300 ? -24.97752 7.84027   -0.24470  1.000 10.19066 ? 279 GLY   A CA  1 
ATOM   2129 C C   . GLY   A 1 300 ? -23.63099 8.28412   -0.78534  1.000 11.08288 ? 279 GLY   A C   1 
ATOM   2130 O O   . GLY   A 1 300 ? -23.46669 9.43596   -1.19753  1.000 13.03233 ? 279 GLY   A O   1 
ATOM   2131 N N   . LEU   A 1 301 ? -22.65083 7.37607   -0.79335  1.000 11.02697 ? 280 LEU   A N   1 
ATOM   2132 C CA  . LEU   A 1 301 ? -21.32978 7.70169   -1.32388  1.000 9.49642  ? 280 LEU   A CA  1 
ATOM   2133 C C   . LEU   A 1 301 ? -21.38491 8.01019   -2.81630  1.000 10.28643 ? 280 LEU   A C   1 
ATOM   2134 O O   . LEU   A 1 301 ? -20.76559 8.97301   -3.28258  1.000 7.76290  ? 280 LEU   A O   1 
ATOM   2135 C CB  . LEU   A 1 301 ? -20.36248 6.54685   -1.05700  1.000 7.60367  ? 280 LEU   A CB  1 
ATOM   2136 C CG  . LEU   A 1 301 ? -18.96691 6.69013   -1.67159  1.000 12.36629 ? 280 LEU   A CG  1 
ATOM   2137 C CD1 . LEU   A 1 301 ? -18.23513 7.87604   -1.06574  1.000 10.67493 ? 280 LEU   A CD1 1 
ATOM   2138 C CD2 . LEU   A 1 301 ? -18.16406 5.40864   -1.49612  1.000 8.79210  ? 280 LEU   A CD2 1 
ATOM   2139 N N   . LEU   A 1 302 ? -22.11506 7.19787   -3.58275  1.000 11.41558 ? 281 LEU   A N   1 
ATOM   2140 C CA  . LEU   A 1 302 ? -22.17079 7.39774   -5.02754  1.000 14.36416 ? 281 LEU   A CA  1 
ATOM   2141 C C   . LEU   A 1 302 ? -22.97218 8.64185   -5.38703  1.000 15.11523 ? 281 LEU   A C   1 
ATOM   2142 O O   . LEU   A 1 302 ? -22.60000 9.37999   -6.30650  1.000 15.33825 ? 281 LEU   A O   1 
ATOM   2143 C CB  . LEU   A 1 302 ? -22.76093 6.16207   -5.70215  1.000 14.81401 ? 281 LEU   A CB  1 
ATOM   2144 C CG  . LEU   A 1 302 ? -21.98791 4.86915   -5.43277  1.000 17.86262 ? 281 LEU   A CG  1 
ATOM   2145 C CD1 . LEU   A 1 302 ? -22.61461 3.71116   -6.16874  1.000 10.71680 ? 281 LEU   A CD1 1 
ATOM   2146 C CD2 . LEU   A 1 302 ? -20.52795 5.02197   -5.81847  1.000 13.77640 ? 281 LEU   A CD2 1 
ATOM   2147 N N   . ALA   A 1 303 ? -24.07287 8.89284   -4.67306  1.000 13.16668 ? 282 ALA   A N   1 
ATOM   2148 C CA  . ALA   A 1 303 ? -24.86975 10.08552  -4.94479  1.000 19.06208 ? 282 ALA   A CA  1 
ATOM   2149 C C   . ALA   A 1 303 ? -24.05110 11.35118  -4.73170  1.000 16.81499 ? 282 ALA   A C   1 
ATOM   2150 O O   . ALA   A 1 303 ? -24.13317 12.29576  -5.52604  1.000 14.24064 ? 282 ALA   A O   1 
ATOM   2151 C CB  . ALA   A 1 303 ? -26.11804 10.10053  -4.06223  1.000 16.25769 ? 282 ALA   A CB  1 
ATOM   2152 N N   . ASP   A 1 304 ? -23.24330 11.38425  -3.67066  1.000 12.54451 ? 283 ASP   A N   1 
ATOM   2153 C CA  . ASP   A 1 304 ? -22.38439 12.53440  -3.42496  1.000 15.47509 ? 283 ASP   A CA  1 
ATOM   2154 C C   . ASP   A 1 304 ? -21.29282 12.68441  -4.47521  1.000 13.66112 ? 283 ASP   A C   1 
ATOM   2155 O O   . ASP   A 1 304 ? -20.64969 13.73780  -4.52865  1.000 18.84438 ? 283 ASP   A O   1 
ATOM   2156 C CB  . ASP   A 1 304 ? -21.76450 12.43744  -2.03122  1.000 12.45702 ? 283 ASP   A CB  1 
ATOM   2157 C CG  . ASP   A 1 304 ? -22.77637 12.68622  -0.93064  1.000 15.07952 ? 283 ASP   A CG  1 
ATOM   2158 O OD1 . ASP   A 1 304 ? -23.90305 13.11864  -1.24961  1.000 21.85843 ? 283 ASP   A OD1 1 
ATOM   2159 O OD2 . ASP   A 1 304 ? -22.44788 12.45453  0.25110   1.000 22.37956 ? 283 ASP   A OD2 1 
ATOM   2160 N N   . ASN   A 1 305 ? -21.06727 11.66541  -5.30266  1.000 12.15494 ? 284 ASN   A N   1 
ATOM   2161 C CA  . ASN   A 1 305 ? -20.15232 11.75999  -6.43114  1.000 12.30218 ? 284 ASN   A CA  1 
ATOM   2162 C C   . ASN   A 1 305 ? -20.88730 11.73468  -7.76817  1.000 14.35392 ? 284 ASN   A C   1 
ATOM   2163 O O   . ASN   A 1 305 ? -20.25779 11.52392  -8.80927  1.000 12.52200 ? 284 ASN   A O   1 
ATOM   2164 C CB  . ASN   A 1 305 ? -19.11317 10.63949  -6.35347  1.000 14.23839 ? 284 ASN   A CB  1 
ATOM   2165 C CG  . ASN   A 1 305 ? -18.08072 10.88343  -5.26227  1.000 20.72529 ? 284 ASN   A CG  1 
ATOM   2166 O OD1 . ASN   A 1 305 ? -17.05974 11.53504  -5.48946  1.000 15.28201 ? 284 ASN   A OD1 1 
ATOM   2167 N ND2 . ASN   A 1 305 ? -18.35562 10.37633  -4.06184  1.000 15.36353 ? 284 ASN   A ND2 1 
ATOM   2168 N N   . ASN   A 1 306 ? -22.20959 11.92677  -7.75159  1.000 16.35599 ? 285 ASN   A N   1 
ATOM   2169 C CA  . ASN   A 1 306 ? -23.01964 12.15165  -8.95317  1.000 18.47819 ? 285 ASN   A CA  1 
ATOM   2170 C C   . ASN   A 1 306 ? -23.04450 10.93888  -9.88383  1.000 20.40820 ? 285 ASN   A C   1 
ATOM   2171 O O   . ASN   A 1 306 ? -23.10841 11.08076  -11.10579 1.000 20.44310 ? 285 ASN   A O   1 
ATOM   2172 C CB  . ASN   A 1 306 ? -22.55164 13.39879  -9.70949  1.000 22.20127 ? 285 ASN   A CB  1 
ATOM   2173 C CG  . ASN   A 1 306 ? -22.49149 14.62984  -8.82601  1.000 24.52395 ? 285 ASN   A CG  1 
ATOM   2174 O OD1 . ASN   A 1 306 ? -23.46178 14.96926  -8.14873  1.000 21.78037 ? 285 ASN   A OD1 1 
ATOM   2175 N ND2 . ASN   A 1 306 ? -21.34934 15.30688  -8.83019  1.000 35.27819 ? 285 ASN   A ND2 1 
ATOM   2176 N N   . ILE   A 1 307 ? -23.01516 9.73258   -9.30969  1.000 17.65058 ? 286 ILE   A N   1 
ATOM   2177 C CA  . ILE   A 1 307 ? -23.19936 8.50484   -10.07571 1.000 12.41164 ? 286 ILE   A CA  1 
ATOM   2178 C C   . ILE   A 1 307 ? -24.13071 7.57328   -9.30908  1.000 13.99139 ? 286 ILE   A C   1 
ATOM   2179 O O   . ILE   A 1 307 ? -24.35533 7.73091   -8.10737  1.000 16.41511 ? 286 ILE   A O   1 
ATOM   2180 C CB  . ILE   A 1 307 ? -21.86857 7.78004   -10.38819 1.000 16.53106 ? 286 ILE   A CB  1 
ATOM   2181 C CG1 . ILE   A 1 307 ? -21.09724 7.47936   -9.10380  1.000 14.38787 ? 286 ILE   A CG1 1 
ATOM   2182 C CG2 . ILE   A 1 307 ? -21.01547 8.59659   -11.35015 1.000 17.85896 ? 286 ILE   A CG2 1 
ATOM   2183 C CD1 . ILE   A 1 307 ? -20.11124 6.33866   -9.25474  1.000 13.19081 ? 286 ILE   A CD1 1 
ATOM   2184 N N   . GLU   A 1 308 ? -24.69071 6.60578   -10.03123 1.000 13.03332 ? 287 GLU   A N   1 
ATOM   2185 C CA  . GLU   A 1 308 ? -25.49255 5.53606   -9.45366  1.000 19.37796 ? 287 GLU   A CA  1 
ATOM   2186 C C   . GLU   A 1 308 ? -24.69429 4.23885   -9.42927  1.000 12.45956 ? 287 GLU   A C   1 
ATOM   2187 O O   . GLU   A 1 308 ? -23.69067 4.09166   -10.13051 1.000 11.12472 ? 287 GLU   A O   1 
ATOM   2188 C CB  . GLU   A 1 308 ? -26.78071 5.31183   -10.24826 1.000 18.54211 ? 287 GLU   A CB  1 
ATOM   2189 C CG  . GLU   A 1 308 ? -27.56199 6.55138   -10.59167 1.000 26.51038 ? 287 GLU   A CG  1 
ATOM   2190 C CD  . GLU   A 1 308 ? -28.75601 6.23214   -11.46609 1.000 26.93003 ? 287 GLU   A CD  1 
ATOM   2191 O OE1 . GLU   A 1 308 ? -28.59456 5.46474   -12.44046 1.000 23.85531 ? 287 GLU   A OE1 1 
ATOM   2192 O OE2 . GLU   A 1 308 ? -29.85781 6.73911   -11.17253 1.000 34.32818 ? 287 GLU   A OE2 1 
ATOM   2193 N N   . SER   A 1 309 ? -25.17422 3.27689   -8.63145  1.000 9.73803  ? 288 SER   A N   1 
ATOM   2194 C CA  . SER   A 1 309 ? -24.49993 1.98243   -8.56820  1.000 13.68881 ? 288 SER   A CA  1 
ATOM   2195 C C   . SER   A 1 309 ? -24.48888 1.29311   -9.92534  1.000 10.83799 ? 288 SER   A C   1 
ATOM   2196 O O   . SER   A 1 309 ? -23.55876 0.53741   -10.23231 1.000 9.67704  ? 288 SER   A O   1 
ATOM   2197 C CB  . SER   A 1 309 ? -25.15763 1.08287   -7.51875  1.000 16.78388 ? 288 SER   A CB  1 
ATOM   2198 O OG  . SER   A 1 309 ? -26.49034 0.75845   -7.86799  1.000 13.76147 ? 288 SER   A OG  1 
ATOM   2199 N N   . GLU   A 1 310 ? -25.50220 1.55066   -10.75278 1.000 9.85756  ? 289 GLU   A N   1 
ATOM   2200 C CA  . GLU   A 1 310 ? -25.54441 0.98366   -12.09412 1.000 13.47614 ? 289 GLU   A CA  1 
ATOM   2201 C C   . GLU   A 1 310 ? -24.43366 1.52270   -12.99066 1.000 10.26666 ? 289 GLU   A C   1 
ATOM   2202 O O   . GLU   A 1 310 ? -24.12146 0.89687   -14.00804 1.000 13.28458 ? 289 GLU   A O   1 
ATOM   2203 C CB  . GLU   A 1 310 ? -26.91599 1.24944   -12.71595 1.000 11.34676 ? 289 GLU   A CB  1 
ATOM   2204 C CG  . GLU   A 1 310 ? -28.07430 0.55177   -12.00261 1.000 14.34757 ? 289 GLU   A CG  1 
ATOM   2205 C CD  . GLU   A 1 310 ? -28.63199 1.35997   -10.83863 1.000 26.45662 ? 289 GLU   A CD  1 
ATOM   2206 O OE1 . GLU   A 1 310 ? -28.03937 2.40453   -10.49393 1.000 17.07679 ? 289 GLU   A OE1 1 
ATOM   2207 O OE2 . GLU   A 1 310 ? -29.67186 0.95662   -10.27378 1.000 29.79423 ? 289 GLU   A OE2 1 
ATOM   2208 N N   . ASN   A 1 311 ? -23.83341 2.66451   -12.63959 1.000 11.73844 ? 290 ASN   A N   1 
ATOM   2209 C CA  . ASN   A 1 311 ? -22.69066 3.18224   -13.38733 1.000 9.22371  ? 290 ASN   A CA  1 
ATOM   2210 C C   . ASN   A 1 311 ? -21.42418 2.36467   -13.15108 1.000 14.67105 ? 290 ASN   A C   1 
ATOM   2211 O O   . ASN   A 1 311 ? -20.48796 2.44688   -13.95574 1.000 14.78321 ? 290 ASN   A O   1 
ATOM   2212 C CB  . ASN   A 1 311 ? -22.42345 4.64281   -13.00508 1.000 12.90401 ? 290 ASN   A CB  1 
ATOM   2213 C CG  . ASN   A 1 311 ? -23.36003 5.61764   -13.69466 1.000 21.32100 ? 290 ASN   A CG  1 
ATOM   2214 O OD1 . ASN   A 1 311 ? -24.12214 6.33133   -13.03882 1.000 24.32381 ? 290 ASN   A OD1 1 
ATOM   2215 N ND2 . ASN   A 1 311 ? -23.29091 5.67270   -15.01706 1.000 21.46569 ? 290 ASN   A ND2 1 
ATOM   2216 N N   . LEU   A 1 312 ? -21.36902 1.59171   -12.06701 1.000 8.52193  ? 291 LEU   A N   1 
ATOM   2217 C CA  . LEU   A 1 312 ? -20.14645 0.88480   -11.70395 1.000 9.04972  ? 291 LEU   A CA  1 
ATOM   2218 C C   . LEU   A 1 312 ? -19.82368 -0.20513  -12.71713 1.000 14.43131 ? 291 LEU   A C   1 
ATOM   2219 O O   . LEU   A 1 312 ? -20.67355 -1.03849  -13.04601 1.000 14.48733 ? 291 LEU   A O   1 
ATOM   2220 C CB  . LEU   A 1 312 ? -20.27469 0.27646   -10.30742 1.000 11.23188 ? 291 LEU   A CB  1 
ATOM   2221 C CG  . LEU   A 1 312 ? -20.36821 1.26095   -9.14117  1.000 13.13187 ? 291 LEU   A CG  1 
ATOM   2222 C CD1 . LEU   A 1 312 ? -20.76901 0.54568   -7.85402  1.000 9.67396  ? 291 LEU   A CD1 1 
ATOM   2223 C CD2 . LEU   A 1 312 ? -19.04675 1.99662   -8.96604  1.000 11.40058 ? 291 LEU   A CD2 1 
ATOM   2224 N N   . TYR   A 1 313 ? -18.58374 -0.20095  -13.20560 1.000 10.63635 ? 292 TYR   A N   1 
ATOM   2225 C CA  . TYR   A 1 313 ? -18.14780 -1.25171  -14.11651 1.000 12.24332 ? 292 TYR   A CA  1 
ATOM   2226 C C   . TYR   A 1 313 ? -17.65697 -2.48106  -13.36262 1.000 15.94828 ? 292 TYR   A C   1 
ATOM   2227 O O   . TYR   A 1 313 ? -17.84885 -3.61156  -13.82345 1.000 14.17959 ? 292 TYR   A O   1 
ATOM   2228 C CB  . TYR   A 1 313 ? -17.05109 -0.73156  -15.04596 1.000 15.47472 ? 292 TYR   A CB  1 
ATOM   2229 C CG  . TYR   A 1 313 ? -16.59202 -1.76201  -16.05293 1.000 19.21415 ? 292 TYR   A CG  1 
ATOM   2230 C CD1 . TYR   A 1 313 ? -17.22155 -1.88988  -17.28491 1.000 24.53939 ? 292 TYR   A CD1 1 
ATOM   2231 C CD2 . TYR   A 1 313 ? -15.53322 -2.61430  -15.76761 1.000 19.80831 ? 292 TYR   A CD2 1 
ATOM   2232 C CE1 . TYR   A 1 313 ? -16.80573 -2.84140  -18.20325 1.000 22.68770 ? 292 TYR   A CE1 1 
ATOM   2233 C CE2 . TYR   A 1 313 ? -15.11388 -3.56373  -16.67501 1.000 24.23050 ? 292 TYR   A CE2 1 
ATOM   2234 C CZ  . TYR   A 1 313 ? -15.74943 -3.67241  -17.89051 1.000 23.32635 ? 292 TYR   A CZ  1 
ATOM   2235 O OH  . TYR   A 1 313 ? -15.32362 -4.62236  -18.78963 1.000 35.69390 ? 292 TYR   A OH  1 
ATOM   2236 N N   . ARG   A 1 314 ? -17.01752 -2.28812  -12.21226 1.000 11.18200 ? 293 ARG   A N   1 
ATOM   2237 C CA  . ARG   A 1 314 ? -16.43718 -3.40406  -11.48137 1.000 17.27294 ? 293 ARG   A CA  1 
ATOM   2238 C C   . ARG   A 1 314 ? -16.73387 -3.27786  -9.99698  1.000 11.54950 ? 293 ARG   A C   1 
ATOM   2239 O O   . ARG   A 1 314 ? -16.52811 -2.21345  -9.40802  1.000 11.56685 ? 293 ARG   A O   1 
ATOM   2240 C CB  . ARG   A 1 314 ? -14.92574 -3.47961  -11.69688 1.000 14.07363 ? 293 ARG   A CB  1 
ATOM   2241 C CG  . ARG   A 1 314 ? -14.27758 -4.58500  -10.89269 1.000 25.84776 ? 293 ARG   A CG  1 
ATOM   2242 C CD  . ARG   A 1 314 ? -12.88460 -4.87486  -11.37884 1.000 31.37698 ? 293 ARG   A CD  1 
ATOM   2243 N NE  . ARG   A 1 314 ? -12.87041 -5.58598  -12.65141 1.000 35.66055 ? 293 ARG   A NE  1 
ATOM   2244 C CZ  . ARG   A 1 314 ? -12.54138 -5.03407  -13.81114 1.000 39.60070 ? 293 ARG   A CZ  1 
ATOM   2245 N NH1 . ARG   A 1 314 ? -12.19497 -3.75947  -13.89643 1.000 36.61526 ? 293 ARG   A NH1 1 
ATOM   2246 N NH2 . ARG   A 1 314 ? -12.54947 -5.78188  -14.91071 1.000 33.93711 ? 293 ARG   A NH2 1 
ATOM   2247 N N   . TRP   A 1 315 ? -17.20964 -4.36720  -9.40401  1.000 12.92584 ? 294 TRP   A N   1 
ATOM   2248 C CA  . TRP   A 1 315 ? -17.35833 -4.48820  -7.96172  1.000 10.88563 ? 294 TRP   A CA  1 
ATOM   2249 C C   . TRP   A 1 315 ? -16.22856 -5.34643  -7.41125  1.000 8.92336  ? 294 TRP   A C   1 
ATOM   2250 O O   . TRP   A 1 315 ? -15.89065 -6.38352  -7.98691  1.000 10.77883 ? 294 TRP   A O   1 
ATOM   2251 C CB  . TRP   A 1 315 ? -18.69814 -5.12304  -7.59441  1.000 10.09145 ? 294 TRP   A CB  1 
ATOM   2252 C CG  . TRP   A 1 315 ? -19.89812 -4.27766  -7.85487  1.000 11.03608 ? 294 TRP   A CG  1 
ATOM   2253 C CD1 . TRP   A 1 315 ? -20.38924 -3.89797  -9.07038  1.000 12.56727 ? 294 TRP   A CD1 1 
ATOM   2254 C CD2 . TRP   A 1 315 ? -20.78951 -3.73782  -6.87445  1.000 9.44713  ? 294 TRP   A CD2 1 
ATOM   2255 N NE1 . TRP   A 1 315 ? -21.52339 -3.13957  -8.90518  1.000 12.86307 ? 294 TRP   A NE1 1 
ATOM   2256 C CE2 . TRP   A 1 315 ? -21.79153 -3.02825  -7.56643  1.000 12.64093 ? 294 TRP   A CE2 1 
ATOM   2257 C CE3 . TRP   A 1 315 ? -20.83542 -3.78122  -5.47753  1.000 13.19630 ? 294 TRP   A CE3 1 
ATOM   2258 C CZ2 . TRP   A 1 315 ? -22.82489 -2.36384  -6.90967  1.000 11.08259 ? 294 TRP   A CZ2 1 
ATOM   2259 C CZ3 . TRP   A 1 315 ? -21.86354 -3.11891  -4.82611  1.000 18.03700 ? 294 TRP   A CZ3 1 
ATOM   2260 C CH2 . TRP   A 1 315 ? -22.84399 -2.42083  -5.54307  1.000 12.82327 ? 294 TRP   A CH2 1 
ATOM   2261 N N   . ILE   A 1 316 ? -15.64492 -4.90803  -6.30325  1.000 6.51306  ? 295 ILE   A N   1 
ATOM   2262 C CA  . ILE   A 1 316 ? -14.63268 -5.67649  -5.58181  1.000 8.52085  ? 295 ILE   A CA  1 
ATOM   2263 C C   . ILE   A 1 316 ? -15.15302 -5.80917  -4.15468  1.000 8.43624  ? 295 ILE   A C   1 
ATOM   2264 O O   . ILE   A 1 316 ? -14.93533 -4.93680  -3.31039  1.000 7.64379  ? 295 ILE   A O   1 
ATOM   2265 C CB  . ILE   A 1 316 ? -13.25506 -5.01106  -5.62245  1.000 7.80962  ? 295 ILE   A CB  1 
ATOM   2266 C CG1 . ILE   A 1 316 ? -12.81842 -4.77333  -7.06932  1.000 11.33843 ? 295 ILE   A CG1 1 
ATOM   2267 C CG2 . ILE   A 1 316 ? -12.22149 -5.87704  -4.90927  1.000 7.47790  ? 295 ILE   A CG2 1 
ATOM   2268 C CD1 . ILE   A 1 316 ? -11.43802 -4.15350  -7.18939  1.000 9.99371  ? 295 ILE   A CD1 1 
ATOM   2269 N N   . VAL   A 1 317 ? -15.85032 -6.90786  -3.87419  1.000 6.75413  ? 296 VAL   A N   1 
ATOM   2270 C CA  . VAL   A 1 317 ? -16.59494 -7.08230  -2.63131  1.000 7.52496  ? 296 VAL   A CA  1 
ATOM   2271 C C   . VAL   A 1 317 ? -15.93184 -8.18200  -1.81438  1.000 8.04587  ? 296 VAL   A C   1 
ATOM   2272 O O   . VAL   A 1 317 ? -15.72920 -9.29623  -2.31251  1.000 6.35561  ? 296 VAL   A O   1 
ATOM   2273 C CB  . VAL   A 1 317 ? -18.07273 -7.41629  -2.90782  1.000 9.89726  ? 296 VAL   A CB  1 
ATOM   2274 C CG1 . VAL   A 1 317 ? -18.80285 -7.75235  -1.61373  1.000 8.03037  ? 296 VAL   A CG1 1 
ATOM   2275 C CG2 . VAL   A 1 317 ? -18.75302 -6.26840  -3.64340  1.000 10.47643 ? 296 VAL   A CG2 1 
ATOM   2276 N N   . HIS   A 1 318 ? -15.60002 -7.86880  -0.56251  1.000 5.20331  ? 297 HIS   A N   1 
ATOM   2277 C CA  . HIS   A 1 318 ? -14.98414 -8.85020  0.32168   1.000 6.20159  ? 297 HIS   A CA  1 
ATOM   2278 C C   . HIS   A 1 318 ? -15.91989 -10.03635 0.52528   1.000 8.45579  ? 297 HIS   A C   1 
ATOM   2279 O O   . HIS   A 1 318 ? -17.07438 -9.84590  0.93195   1.000 10.39711 ? 297 HIS   A O   1 
ATOM   2280 C CB  . HIS   A 1 318 ? -14.65609 -8.22892  1.67828   1.000 9.89220  ? 297 HIS   A CB  1 
ATOM   2281 C CG  . HIS   A 1 318 ? -14.27201 -9.23314  2.72162   1.000 7.73532  ? 297 HIS   A CG  1 
ATOM   2282 N ND1 . HIS   A 1 318 ? -13.06348 -9.89481  2.70975   1.000 9.17796  ? 297 HIS   A ND1 1 
ATOM   2283 C CD2 . HIS   A 1 318 ? -14.95275 -9.71393  3.78863   1.000 11.19430 ? 297 HIS   A CD2 1 
ATOM   2284 C CE1 . HIS   A 1 318 ? -13.00782 -10.72532 3.73554   1.000 8.68466  ? 297 HIS   A CE1 1 
ATOM   2285 N NE2 . HIS   A 1 318 ? -14.14204 -10.63493 4.40617   1.000 8.96229  ? 297 HIS   A NE2 1 
ATOM   2286 N N   . PRO   A 1 319 ? -15.46831 -11.26168 0.26845   1.000 6.91211  ? 298 PRO   A N   1 
ATOM   2287 C CA  . PRO   A 1 319 ? -16.31924 -12.45217 0.45060   1.000 15.94192 ? 298 PRO   A CA  1 
ATOM   2288 C C   . PRO   A 1 319 ? -16.29450 -12.97477 1.88369   1.000 18.37478 ? 298 PRO   A C   1 
ATOM   2289 O O   . PRO   A 1 319 ? -15.58755 -13.91877 2.23432   1.000 22.39039 ? 298 PRO   A O   1 
ATOM   2290 C CB  . PRO   A 1 319 ? -15.70403 -13.45318 -0.52839  1.000 15.07104 ? 298 PRO   A CB  1 
ATOM   2291 C CG  . PRO   A 1 319 ? -14.24217 -13.10137 -0.52291  1.000 10.95895 ? 298 PRO   A CG  1 
ATOM   2292 C CD  . PRO   A 1 319 ? -14.15833 -11.60433 -0.31373  1.000 7.69130  ? 298 PRO   A CD  1 
ATOM   2293 N N   . GLY   A 1 320 ? -17.08473 -12.33333 2.74686   1.000 13.93996 ? 299 GLY   A N   1 
ATOM   2294 C CA  . GLY   A 1 320 ? -17.25948 -12.85508 4.09152   1.000 18.17235 ? 299 GLY   A CA  1 
ATOM   2295 C C   . GLY   A 1 320 ? -17.78615 -14.27576 4.09227   1.000 19.41149 ? 299 GLY   A C   1 
ATOM   2296 O O   . GLY   A 1 320 ? -17.46287 -15.06478 4.98389   1.000 31.56952 ? 299 GLY   A O   1 
ATOM   2297 N N   . GLY   A 1 321 ? -18.59181 -14.62002 3.09161   1.000 26.09741 ? 300 GLY   A N   1 
ATOM   2298 C CA  . GLY   A 1 321 ? -19.08948 -15.95960 2.90015   1.000 26.05509 ? 300 GLY   A CA  1 
ATOM   2299 C C   . GLY   A 1 321 ? -20.00535 -16.00667 1.69406   1.000 24.89486 ? 300 GLY   A C   1 
ATOM   2300 O O   . GLY   A 1 321 ? -20.33324 -14.97268 1.10302   1.000 15.99195 ? 300 GLY   A O   1 
ATOM   2301 N N   . PRO   A 1 322 ? -20.42984 -17.20848 1.29459   1.000 33.42245 ? 301 PRO   A N   1 
ATOM   2302 C CA  . PRO   A 1 322 ? -21.38523 -17.30375 0.17551   1.000 32.58432 ? 301 PRO   A CA  1 
ATOM   2303 C C   . PRO   A 1 322 ? -22.67903 -16.54874 0.43152   1.000 31.01019 ? 301 PRO   A C   1 
ATOM   2304 O O   . PRO   A 1 322 ? -23.27391 -16.01357 -0.51349  1.000 21.93104 ? 301 PRO   A O   1 
ATOM   2305 C CB  . PRO   A 1 322 ? -21.62883 -18.81587 0.03327   1.000 32.48263 ? 301 PRO   A CB  1 
ATOM   2306 C CG  . PRO   A 1 322 ? -20.96236 -19.46791 1.20727   1.000 25.36550 ? 301 PRO   A CG  1 
ATOM   2307 C CD  . PRO   A 1 322 ? -19.94631 -18.52246 1.74862   1.000 30.50359 ? 301 PRO   A CD  1 
ATOM   2308 N N   . LYS   A 1 323 ? -23.12395 -16.48914 1.68998   1.000 28.79638 ? 302 LYS   A N   1 
ATOM   2309 C CA  . LYS   A 1 323 ? -24.33031 -15.74449 2.04136   1.000 25.76628 ? 302 LYS   A CA  1 
ATOM   2310 C C   . LYS   A 1 323 ? -24.11409 -14.23912 1.92174   1.000 22.60864 ? 302 LYS   A C   1 
ATOM   2311 O O   . LYS   A 1 323 ? -25.02507 -13.50398 1.52041   1.000 18.78030 ? 302 LYS   A O   1 
ATOM   2312 C CB  . LYS   A 1 323 ? -24.78243 -16.10292 3.46228   1.000 28.90644 ? 302 LYS   A CB  1 
ATOM   2313 C CG  . LYS   A 1 323 ? -23.76230 -15.83485 4.59398   1.000 31.10786 ? 302 LYS   A CG  1 
ATOM   2314 C CD  . LYS   A 1 323 ? -22.57948 -16.80998 4.62318   1.000 25.85430 ? 302 LYS   A CD  1 
ATOM   2315 C CE  . LYS   A 1 323 ? -21.52001 -16.36950 5.62054   1.000 33.55657 ? 302 LYS   A CE  1 
ATOM   2316 N NZ  . LYS   A 1 323 ? -20.44005 -17.38179 5.79217   1.000 39.32877 ? 302 LYS   A NZ  1 
ATOM   2317 N N   . VAL   A 1 324 ? -22.92284 -13.75984 2.28588   1.000 17.25460 ? 303 VAL   A N   1 
ATOM   2318 C CA  . VAL   A 1 324 ? -22.62724 -12.33448 2.17554   1.000 17.09488 ? 303 VAL   A CA  1 
ATOM   2319 C C   . VAL   A 1 324 ? -22.64773 -11.89766 0.71741   1.000 14.57095 ? 303 VAL   A C   1 
ATOM   2320 O O   . VAL   A 1 324 ? -23.22806 -10.86077 0.37065   1.000 10.17244 ? 303 VAL   A O   1 
ATOM   2321 C CB  . VAL   A 1 324 ? -21.27656 -12.01792 2.84251   1.000 14.68292 ? 303 VAL   A CB  1 
ATOM   2322 C CG1 . VAL   A 1 324 ? -20.88372 -10.57616 2.57760   1.000 11.87931 ? 303 VAL   A CG1 1 
ATOM   2323 C CG2 . VAL   A 1 324 ? -21.35219 -12.28603 4.33873   1.000 18.37548 ? 303 VAL   A CG2 1 
ATOM   2324 N N   . ILE   A 1 325 ? -22.02409 -12.68767 -0.15909  1.000 13.14264 ? 304 ILE   A N   1 
ATOM   2325 C CA  . ILE   A 1 325 ? -21.99458 -12.35780 -1.58149  1.000 12.83676 ? 304 ILE   A CA  1 
ATOM   2326 C C   . ILE   A 1 325 ? -23.40786 -12.30287 -2.14529  1.000 12.26336 ? 304 ILE   A C   1 
ATOM   2327 O O   . ILE   A 1 325 ? -23.76161 -11.37857 -2.88766  1.000 13.18080 ? 304 ILE   A O   1 
ATOM   2328 C CB  . ILE   A 1 325 ? -21.11796 -13.37165 -2.33968  1.000 16.98672 ? 304 ILE   A CB  1 
ATOM   2329 C CG1 . ILE   A 1 325 ? -19.67801 -13.31343 -1.82303  1.000 15.43705 ? 304 ILE   A CG1 1 
ATOM   2330 C CG2 . ILE   A 1 325 ? -21.18025 -13.11697 -3.84038  1.000 12.87499 ? 304 ILE   A CG2 1 
ATOM   2331 C CD1 . ILE   A 1 325 ? -18.78341 -14.42463 -2.35339  1.000 9.84527  ? 304 ILE   A CD1 1 
ATOM   2332 N N   . ASP   A 1 326 ? -24.24168 -13.28215 -1.78843  1.000 16.82376 ? 305 ASP   A N   1 
ATOM   2333 C CA  . ASP   A 1 326 ? -25.61696 -13.30547 -2.27652  1.000 14.95156 ? 305 ASP   A CA  1 
ATOM   2334 C C   . ASP   A 1 326 ? -26.39486 -12.08662 -1.79808  1.000 16.66567 ? 305 ASP   A C   1 
ATOM   2335 O O   . ASP   A 1 326 ? -27.19628 -11.51717 -2.54932  1.000 15.20033 ? 305 ASP   A O   1 
ATOM   2336 C CB  . ASP   A 1 326 ? -26.30823 -14.59271 -1.82453  1.000 17.91114 ? 305 ASP   A CB  1 
ATOM   2337 C CG  . ASP   A 1 326 ? -25.68880 -15.83309 -2.43822  1.000 23.57239 ? 305 ASP   A CG  1 
ATOM   2338 O OD1 . ASP   A 1 326 ? -24.95446 -15.69929 -3.43951  1.000 25.99157 ? 305 ASP   A OD1 1 
ATOM   2339 O OD2 . ASP   A 1 326 ? -25.92689 -16.94084 -1.91194  1.000 22.87260 ? 305 ASP   A OD2 1 
ATOM   2340 N N   . THR   A 1 327 ? -26.17772 -11.67654 -0.54638  1.000 11.56585 ? 306 THR   A N   1 
ATOM   2341 C CA  . THR   A 1 327 ? -26.90695 -10.53502 -0.00463  1.000 12.89080 ? 306 THR   A CA  1 
ATOM   2342 C C   . THR   A 1 327 ? -26.55582 -9.25011  -0.74414  1.000 11.34326 ? 306 THR   A C   1 
ATOM   2343 O O   . THR   A 1 327 ? -27.44567 -8.46351  -1.08967  1.000 13.06777 ? 306 THR   A O   1 
ATOM   2344 C CB  . THR   A 1 327 ? -26.62441 -10.39462 1.49134   1.000 17.05230 ? 306 THR   A CB  1 
ATOM   2345 O OG1 . THR   A 1 327 ? -27.19588 -11.50858 2.18477   1.000 15.85256 ? 306 THR   A OG1 1 
ATOM   2346 C CG2 . THR   A 1 327 ? -27.23350 -9.10883  2.03368   1.000 20.23711 ? 306 THR   A CG2 1 
ATOM   2347 N N   . VAL   A 1 328 ? -25.26638 -9.02293  -1.00833  1.000 8.89211  ? 307 VAL   A N   1 
ATOM   2348 C CA  . VAL   A 1 328 ? -24.87335 -7.84422  -1.77643  1.000 12.92736 ? 307 VAL   A CA  1 
ATOM   2349 C C   . VAL   A 1 328 ? -25.49661 -7.89385  -3.16441  1.000 10.79621 ? 307 VAL   A C   1 
ATOM   2350 O O   . VAL   A 1 328 ? -26.00575 -6.88651  -3.67258  1.000 11.50010 ? 307 VAL   A O   1 
ATOM   2351 C CB  . VAL   A 1 328 ? -23.33889 -7.73272  -1.84848  1.000 8.66081  ? 307 VAL   A CB  1 
ATOM   2352 C CG1 . VAL   A 1 328 ? -22.93772 -6.58198  -2.75865  1.000 6.03902  ? 307 VAL   A CG1 1 
ATOM   2353 C CG2 . VAL   A 1 328 ? -22.75194 -7.55003  -0.45542  1.000 7.36914  ? 307 VAL   A CG2 1 
ATOM   2354 N N   . GLU   A 1 329 ? -25.47559 -9.07355  -3.78908  1.000 15.31420 ? 308 GLU   A N   1 
ATOM   2355 C CA  . GLU   A 1 329 ? -26.10345 -9.26892  -5.09234  1.000 9.58376  ? 308 GLU   A CA  1 
ATOM   2356 C C   . GLU   A 1 329 ? -27.56414 -8.83554  -5.08275  1.000 11.96473 ? 308 GLU   A C   1 
ATOM   2357 O O   . GLU   A 1 329 ? -28.00940 -8.08592  -5.95961  1.000 14.08384 ? 308 GLU   A O   1 
ATOM   2358 C CB  . GLU   A 1 329 ? -25.99472 -10.74081 -5.48646  1.000 10.88606 ? 308 GLU   A CB  1 
ATOM   2359 C CG  . GLU   A 1 329 ? -25.46280 -10.99920 -6.86739  1.000 24.27445 ? 308 GLU   A CG  1 
ATOM   2360 C CD  . GLU   A 1 329 ? -25.33857 -12.48119 -7.15459  1.000 24.40233 ? 308 GLU   A CD  1 
ATOM   2361 O OE1 . GLU   A 1 329 ? -26.33822 -13.20906 -6.97119  1.000 32.86703 ? 308 GLU   A OE1 1 
ATOM   2362 O OE2 . GLU   A 1 329 ? -24.24010 -12.91973 -7.55349  1.000 28.00767 ? 308 GLU   A OE2 1 
ATOM   2363 N N   . ALA   A 1 330 ? -28.32556 -9.30228  -4.09023  1.000 14.94732 ? 309 ALA   A N   1 
ATOM   2364 C CA  . ALA   A 1 330 ? -29.75887 -9.02937  -4.05643  1.000 15.41915 ? 309 ALA   A CA  1 
ATOM   2365 C C   . ALA   A 1 330 ? -30.04752 -7.57041  -3.72395  1.000 15.64721 ? 309 ALA   A C   1 
ATOM   2366 O O   . ALA   A 1 330 ? -30.97065 -6.97176  -4.28881  1.000 14.49211 ? 309 ALA   A O   1 
ATOM   2367 C CB  . ALA   A 1 330 ? -30.44328 -9.95308  -3.04882  1.000 18.21505 ? 309 ALA   A CB  1 
ATOM   2368 N N   . GLU   A 1 331 ? -29.27532 -6.98253  -2.80650  1.000 15.91987 ? 310 GLU   A N   1 
ATOM   2369 C CA  . GLU   A 1 331 ? -29.53513 -5.60552  -2.39725  1.000 16.74565 ? 310 GLU   A CA  1 
ATOM   2370 C C   . GLU   A 1 331 ? -29.39105 -4.63857  -3.56572  1.000 15.96225 ? 310 GLU   A C   1 
ATOM   2371 O O   . GLU   A 1 331 ? -30.13103 -3.65251  -3.65946  1.000 15.76374 ? 310 GLU   A O   1 
ATOM   2372 C CB  . GLU   A 1 331 ? -28.59715 -5.20850  -1.25714  1.000 16.85034 ? 310 GLU   A CB  1 
ATOM   2373 C CG  . GLU   A 1 331 ? -28.97550 -5.78934  0.09251   1.000 13.20256 ? 310 GLU   A CG  1 
ATOM   2374 C CD  . GLU   A 1 331 ? -30.32900 -5.30242  0.57697   1.000 17.56417 ? 310 GLU   A CD  1 
ATOM   2375 O OE1 . GLU   A 1 331 ? -30.44296 -4.10965  0.93109   1.000 22.15788 ? 310 GLU   A OE1 1 
ATOM   2376 O OE2 . GLU   A 1 331 ? -31.27648 -6.11293  0.60886   1.000 21.88109 ? 310 GLU   A OE2 1 
ATOM   2377 N N   . PHE   A 1 332 ? -28.44808 -4.90149  -4.46801  1.000 12.04400 ? 311 PHE   A N   1 
ATOM   2378 C CA  . PHE   A 1 332 ? -28.16423 -3.99285  -5.56858  1.000 12.80393 ? 311 PHE   A CA  1 
ATOM   2379 C C   . PHE   A 1 332 ? -28.67286 -4.50417  -6.90930  1.000 17.92089 ? 311 PHE   A C   1 
ATOM   2380 O O   . PHE   A 1 332 ? -28.36886 -3.90160  -7.94612  1.000 14.77282 ? 311 PHE   A O   1 
ATOM   2381 C CB  . PHE   A 1 332 ? -26.66444 -3.71469  -5.62973  1.000 13.42904 ? 311 PHE   A CB  1 
ATOM   2382 C CG  . PHE   A 1 332 ? -26.18132 -2.85639  -4.50385  1.000 14.69965 ? 311 PHE   A CG  1 
ATOM   2383 C CD1 . PHE   A 1 332 ? -26.26968 -1.47714  -4.58339  1.000 14.61435 ? 311 PHE   A CD1 1 
ATOM   2384 C CD2 . PHE   A 1 332 ? -25.67193 -3.42823  -3.34950  1.000 10.08350 ? 311 PHE   A CD2 1 
ATOM   2385 C CE1 . PHE   A 1 332 ? -25.84068 -0.68268  -3.54271  1.000 17.74442 ? 311 PHE   A CE1 1 
ATOM   2386 C CE2 . PHE   A 1 332 ? -25.23938 -2.63763  -2.30366  1.000 16.35859 ? 311 PHE   A CE2 1 
ATOM   2387 C CZ  . PHE   A 1 332 ? -25.32781 -1.26236  -2.40134  1.000 16.38000 ? 311 PHE   A CZ  1 
ATOM   2388 N N   . GLY   A 1 333 ? -29.43898 -5.59124  -6.91378  1.000 14.09792 ? 312 GLY   A N   1 
ATOM   2389 C CA  . GLY   A 1 333 ? -30.01113 -6.10152  -8.15050  1.000 16.58288 ? 312 GLY   A CA  1 
ATOM   2390 C C   . GLY   A 1 333 ? -28.97649 -6.46308  -9.19211  1.000 18.82267 ? 312 GLY   A C   1 
ATOM   2391 O O   . GLY   A 1 333 ? -29.19701 -6.23573  -10.38755 1.000 15.03626 ? 312 GLY   A O   1 
ATOM   2392 N N   . LEU   A 1 334 ? -27.84774 -7.02066  -8.76487  1.000 12.40383 ? 313 LEU   A N   1 
ATOM   2393 C CA  . LEU   A 1 334 ? -26.74778 -7.30535  -9.67199  1.000 13.20227 ? 313 LEU   A CA  1 
ATOM   2394 C C   . LEU   A 1 334 ? -26.98628 -8.60949  -10.43045 1.000 15.56738 ? 313 LEU   A C   1 
ATOM   2395 O O   . LEU   A 1 334 ? -27.74300 -9.48373  -9.99929  1.000 15.67036 ? 313 LEU   A O   1 
ATOM   2396 C CB  . LEU   A 1 334 ? -25.42771 -7.38428  -8.90249  1.000 12.95517 ? 313 LEU   A CB  1 
ATOM   2397 C CG  . LEU   A 1 334 ? -25.06151 -6.19112  -8.01430  1.000 9.24341  ? 313 LEU   A CG  1 
ATOM   2398 C CD1 . LEU   A 1 334 ? -23.72822 -6.43567  -7.31507  1.000 12.29381 ? 313 LEU   A CD1 1 
ATOM   2399 C CD2 . LEU   A 1 334 ? -25.00723 -4.91097  -8.83006  1.000 11.86753 ? 313 LEU   A CD2 1 
ATOM   2400 N N   . ASP   A 1 335 ? -26.32107 -8.73138  -11.57706 1.000 14.58018 ? 314 ASP   A N   1 
ATOM   2401 C CA  . ASP   A 1 335 ? -26.33652 -9.98203  -12.31966 1.000 19.82111 ? 314 ASP   A CA  1 
ATOM   2402 C C   . ASP   A 1 335 ? -25.51659 -11.03875 -11.58125 1.000 19.70039 ? 314 ASP   A C   1 
ATOM   2403 O O   . ASP   A 1 335 ? -24.65397 -10.72882 -10.75538 1.000 17.45188 ? 314 ASP   A O   1 
ATOM   2404 C CB  . ASP   A 1 335 ? -25.79388 -9.77111  -13.73630 1.000 29.58997 ? 314 ASP   A CB  1 
ATOM   2405 C CG  . ASP   A 1 335 ? -25.69589 -11.06319 -14.52676 1.000 41.04446 ? 314 ASP   A CG  1 
ATOM   2406 O OD1 . ASP   A 1 335 ? -26.68147 -11.42303 -15.20453 1.000 48.80961 ? 314 ASP   A OD1 1 
ATOM   2407 O OD2 . ASP   A 1 335 ? -24.63588 -11.72230 -14.46472 1.000 40.08961 ? 314 ASP   A OD2 1 
ATOM   2408 N N   . SER   A 1 336 ? -25.78484 -12.30628 -11.90468 1.000 20.92483 ? 315 SER   A N   1 
ATOM   2409 C CA  . SER   A 1 336 ? -25.17201 -13.42496 -11.19704 1.000 26.81182 ? 315 SER   A CA  1 
ATOM   2410 C C   . SER   A 1 336 ? -23.66044 -13.49536 -11.37678 1.000 21.53074 ? 315 SER   A C   1 
ATOM   2411 O O   . SER   A 1 336 ? -23.00335 -14.24532 -10.64648 1.000 27.55770 ? 315 SER   A O   1 
ATOM   2412 C CB  . SER   A 1 336 ? -25.79927 -14.74093 -11.66398 1.000 28.44348 ? 315 SER   A CB  1 
ATOM   2413 O OG  . SER   A 1 336 ? -25.51498 -14.97936 -13.03235 1.000 28.33016 ? 315 SER   A OG  1 
ATOM   2414 N N   . GLN   A 1 337 ? -23.09004 -12.75504 -12.32331 1.000 19.79872 ? 316 GLN   A N   1 
ATOM   2415 C CA  . GLN   A 1 337 ? -21.65254 -12.78932 -12.54742 1.000 19.99094 ? 316 GLN   A CA  1 
ATOM   2416 C C   . GLN   A 1 337 ? -20.94144 -11.50873 -12.12908 1.000 12.50944 ? 316 GLN   A C   1 
ATOM   2417 O O   . GLN   A 1 337 ? -19.70951 -11.45497 -12.19406 1.000 12.49691 ? 316 GLN   A O   1 
ATOM   2418 C CB  . GLN   A 1 337 ? -21.35854 -13.09345 -14.02070 1.000 23.51696 ? 316 GLN   A CB  1 
ATOM   2419 C CG  . GLN   A 1 337 ? -21.81955 -14.47395 -14.47520 1.000 26.68917 ? 316 GLN   A CG  1 
ATOM   2420 C CD  . GLN   A 1 337 ? -21.07617 -15.59705 -13.77303 1.000 33.04536 ? 316 GLN   A CD  1 
ATOM   2421 O OE1 . GLN   A 1 337 ? -21.58022 -16.19600 -12.82200 1.000 45.40543 ? 316 GLN   A OE1 1 
ATOM   2422 N NE2 . GLN   A 1 337 ? -19.86534 -15.88289 -14.23760 1.000 32.30263 ? 316 GLN   A NE2 1 
ATOM   2423 N N   . THR   A 1 338 ? -21.67515 -10.48649 -11.68308 1.000 10.88264 ? 317 THR   A N   1 
ATOM   2424 C CA  . THR   A 1 338 ? -21.04142 -9.22843  -11.29834 1.000 11.40833 ? 317 THR   A CA  1 
ATOM   2425 C C   . THR   A 1 338 ? -20.08431 -9.41596  -10.12474 1.000 11.20815 ? 317 THR   A C   1 
ATOM   2426 O O   . THR   A 1 338 ? -19.04081 -8.75507  -10.06128 1.000 13.53704 ? 317 THR   A O   1 
ATOM   2427 C CB  . THR   A 1 338 ? -22.11620 -8.19198  -10.96268 1.000 15.00055 ? 317 THR   A CB  1 
ATOM   2428 O OG1 . THR   A 1 338 ? -22.98772 -8.03179  -12.08990 1.000 14.82318 ? 317 THR   A OG1 1 
ATOM   2429 C CG2 . THR   A 1 338 ? -21.49093 -6.84433  -10.62677 1.000 11.77218 ? 317 THR   A CG2 1 
ATOM   2430 N N   . LEU   A 1 339 ? -20.40773 -10.32174 -9.20096  1.000 9.40073  ? 318 LEU   A N   1 
ATOM   2431 C CA  . LEU   A 1 339 ? -19.57089 -10.59851 -8.03906  1.000 11.43642 ? 318 LEU   A CA  1 
ATOM   2432 C C   . LEU   A 1 339 ? -18.80086 -11.90822 -8.17620  1.000 11.18456 ? 318 LEU   A C   1 
ATOM   2433 O O   . LEU   A 1 339 ? -18.42878 -12.51518 -7.16609  1.000 11.72899 ? 318 LEU   A O   1 
ATOM   2434 C CB  . LEU   A 1 339 ? -20.42014 -10.61765 -6.76848  1.000 9.99722  ? 318 LEU   A CB  1 
ATOM   2435 C CG  . LEU   A 1 339 ? -21.14150 -9.30998  -6.43739  1.000 9.80113  ? 318 LEU   A CG  1 
ATOM   2436 C CD1 . LEU   A 1 339 ? -21.75153 -9.35163  -5.04334  1.000 10.03032 ? 318 LEU   A CD1 1 
ATOM   2437 C CD2 . LEU   A 1 339 ? -20.19800 -8.13347  -6.57458  1.000 10.10201 ? 318 LEU   A CD2 1 
ATOM   2438 N N   . GLN   A 1 340 ? -18.55633 -12.35843 -9.41160  1.000 9.37249  ? 319 GLN   A N   1 
ATOM   2439 C CA  . GLN   A 1 340 ? -17.84992 -13.62062 -9.61505  1.000 10.30282 ? 319 GLN   A CA  1 
ATOM   2440 C C   . GLN   A 1 340 ? -16.45485 -13.59134 -9.00546  1.000 8.28877  ? 319 GLN   A C   1 
ATOM   2441 O O   . GLN   A 1 340 ? -15.97807 -14.61467 -8.50357  1.000 8.27885  ? 319 GLN   A O   1 
ATOM   2442 C CB  . GLN   A 1 340 ? -17.76726 -13.94654 -11.10762 1.000 11.88316 ? 319 GLN   A CB  1 
ATOM   2443 C CG  . GLN   A 1 340 ? -17.42203 -15.40022 -11.42045 1.000 16.85223 ? 319 GLN   A CG  1 
ATOM   2444 C CD  . GLN   A 1 340 ? -18.23567 -16.39512 -10.61307 1.000 17.81443 ? 319 GLN   A CD  1 
ATOM   2445 O OE1 . GLN   A 1 340 ? -19.44992 -16.25142 -10.46582 1.000 20.17720 ? 319 GLN   A OE1 1 
ATOM   2446 N NE2 . GLN   A 1 340 ? -17.56683 -17.41197 -10.08329 1.000 17.50080 ? 319 GLN   A NE2 1 
ATOM   2447 N N   . LEU   A 1 341 ? -15.78957 -12.43378 -9.03775  1.000 9.62587  ? 320 LEU   A N   1 
ATOM   2448 C CA  . LEU   A 1 341 ? -14.45110 -12.32730 -8.46571  1.000 8.19890  ? 320 LEU   A CA  1 
ATOM   2449 C C   . LEU   A 1 341 ? -14.44818 -12.66833 -6.98155  1.000 6.28454  ? 320 LEU   A C   1 
ATOM   2450 O O   . LEU   A 1 341 ? -13.47742 -13.24692 -6.47938  1.000 10.05871 ? 320 LEU   A O   1 
ATOM   2451 C CB  . LEU   A 1 341 ? -13.90058 -10.91982 -8.69118  1.000 11.40241 ? 320 LEU   A CB  1 
ATOM   2452 C CG  . LEU   A 1 341 ? -12.55050 -10.59199 -8.05456  1.000 11.15655 ? 320 LEU   A CG  1 
ATOM   2453 C CD1 . LEU   A 1 341 ? -11.43996 -11.37662 -8.73397  1.000 17.05082 ? 320 LEU   A CD1 1 
ATOM   2454 C CD2 . LEU   A 1 341 ? -12.28372 -9.09853  -8.11876  1.000 9.74331  ? 320 LEU   A CD2 1 
ATOM   2455 N N   . SER   A 1 342 ? -15.52124 -12.32150 -6.26581  1.000 5.80119  ? 321 SER   A N   1 
ATOM   2456 C CA  . SER   A 1 342 ? -15.63015 -12.70766 -4.86252  1.000 8.29622  ? 321 SER   A CA  1 
ATOM   2457 C C   . SER   A 1 342 ? -15.69202 -14.22219 -4.71120  1.000 8.39592  ? 321 SER   A C   1 
ATOM   2458 O O   . SER   A 1 342 ? -15.05538 -14.79121 -3.81668  1.000 7.37474  ? 321 SER   A O   1 
ATOM   2459 C CB  . SER   A 1 342 ? -16.86294 -12.05873 -4.23185  1.000 6.62171  ? 321 SER   A CB  1 
ATOM   2460 O OG  . SER   A 1 342 ? -16.86143 -10.65183 -4.40741  1.000 10.11663 ? 321 SER   A OG  1 
ATOM   2461 N N   . ARG   A 1 343 ? -16.45381 -14.89148 -5.58022  1.000 9.26063  ? 322 ARG   A N   1 
ATOM   2462 C CA  . ARG   A 1 343 ? -16.59564 -16.34047 -5.48413  1.000 9.81331  ? 322 ARG   A CA  1 
ATOM   2463 C C   . ARG   A 1 343 ? -15.32384 -17.05382 -5.92188  1.000 7.25464  ? 322 ARG   A C   1 
ATOM   2464 O O   . ARG   A 1 343 ? -14.92071 -18.04704 -5.30551  1.000 8.46787  ? 322 ARG   A O   1 
ATOM   2465 C CB  . ARG   A 1 343 ? -17.78627 -16.80572 -6.32112  1.000 7.61571  ? 322 ARG   A CB  1 
ATOM   2466 C CG  . ARG   A 1 343 ? -19.08220 -16.09580 -5.97611  1.000 9.28696  ? 322 ARG   A CG  1 
ATOM   2467 C CD  . ARG   A 1 343 ? -20.29599 -16.83777 -6.50578  1.000 15.12022 ? 322 ARG   A CD  1 
ATOM   2468 N NE  . ARG   A 1 343 ? -21.52937 -16.28040 -5.96462  1.000 21.19991 ? 322 ARG   A NE  1 
ATOM   2469 C CZ  . ARG   A 1 343 ? -22.24041 -15.32883 -6.55341  1.000 25.27026 ? 322 ARG   A CZ  1 
ATOM   2470 N NH1 . ARG   A 1 343 ? -21.87045 -14.80638 -7.71215  1.000 24.94488 ? 322 ARG   A NH1 1 
ATOM   2471 N NH2 . ARG   A 1 343 ? -23.34999 -14.88982 -5.96522  1.000 22.82136 ? 322 ARG   A NH2 1 
ATOM   2472 N N   . ASP   A 1 344 ? -14.68706 -16.57526 -6.99288  1.000 9.09142  ? 323 ASP   A N   1 
ATOM   2473 C CA  . ASP   A 1 344 ? -13.44346 -17.19321 -7.43924  1.000 10.20441 ? 323 ASP   A CA  1 
ATOM   2474 C C   . ASP   A 1 344 ? -12.35472 -17.05315 -6.38601  1.000 12.24269 ? 323 ASP   A C   1 
ATOM   2475 O O   . ASP   A 1 344 ? -11.61403 -18.00651 -6.11660  1.000 11.86307 ? 323 ASP   A O   1 
ATOM   2476 C CB  . ASP   A 1 344 ? -12.99945 -16.58139 -8.76660  1.000 11.31226 ? 323 ASP   A CB  1 
ATOM   2477 C CG  . ASP   A 1 344 ? -13.92604 -16.94337 -9.90755  1.000 15.29451 ? 323 ASP   A CG  1 
ATOM   2478 O OD1 . ASP   A 1 344 ? -14.73445 -17.87796 -9.73233  1.000 11.29189 ? 323 ASP   A OD1 1 
ATOM   2479 O OD2 . ASP   A 1 344 ? -13.85122 -16.29289 -10.97272 1.000 11.91222 ? 323 ASP   A OD2 1 
ATOM   2480 N N   . THR   A 1 345 ? -12.25291 -15.87594 -5.76723  1.000 12.22943 ? 324 THR   A N   1 
ATOM   2481 C CA  . THR   A 1 345 ? -11.25280 -15.68403 -4.72315  1.000 9.03297  ? 324 THR   A CA  1 
ATOM   2482 C C   . THR   A 1 345 ? -11.49472 -16.63715 -3.56224  1.000 7.17902  ? 324 THR   A C   1 
ATOM   2483 O O   . THR   A 1 345 ? -10.56009 -17.28257 -3.07472  1.000 8.67537  ? 324 THR   A O   1 
ATOM   2484 C CB  . THR   A 1 345 ? -11.26484 -14.23147 -4.24387  1.000 9.53557  ? 324 THR   A CB  1 
ATOM   2485 O OG1 . THR   A 1 345 ? -10.81560 -13.37683 -5.30091  1.000 6.87241  ? 324 THR   A OG1 1 
ATOM   2486 C CG2 . THR   A 1 345 ? -10.35383 -14.05583 -3.03736  1.000 7.89537  ? 324 THR   A CG2 1 
ATOM   2487 N N   . LEU   A 1 346 ? -12.75314 -16.77129 -3.13603  1.000 13.10442 ? 325 LEU   A N   1 
ATOM   2488 C CA  . LEU   A 1 346 ? -13.07037 -17.67714 -2.03784  1.000 12.78923 ? 325 LEU   A CA  1 
ATOM   2489 C C   . LEU   A 1 346 ? -12.66075 -19.10589 -2.37627  1.000 13.84618 ? 325 LEU   A C   1 
ATOM   2490 O O   . LEU   A 1 346 ? -12.09378 -19.81340 -1.53660  1.000 12.13883 ? 325 LEU   A O   1 
ATOM   2491 C CB  . LEU   A 1 346 ? -14.56445 -17.59329 -1.71336  1.000 13.11600 ? 325 LEU   A CB  1 
ATOM   2492 C CG  . LEU   A 1 346 ? -15.04769 -17.91720 -0.29663  1.000 17.96394 ? 325 LEU   A CG  1 
ATOM   2493 C CD1 . LEU   A 1 346 ? -14.31163 -17.08311 0.74279   1.000 14.95708 ? 325 LEU   A CD1 1 
ATOM   2494 C CD2 . LEU   A 1 346 ? -16.55569 -17.70393 -0.18383  1.000 17.69406 ? 325 LEU   A CD2 1 
ATOM   2495 N N   . ALA   A 1 347 ? -12.91142 -19.53891 -3.61351  1.000 12.41903 ? 326 ALA   A N   1 
ATOM   2496 C CA  . ALA   A 1 347 ? -12.49920 -20.87889 -4.01748  1.000 12.26591 ? 326 ALA   A CA  1 
ATOM   2497 C C   . ALA   A 1 347 ? -10.98014 -21.02385 -4.00127  1.000 11.67153 ? 326 ALA   A C   1 
ATOM   2498 O O   . ALA   A 1 347 ? -10.45384 -22.06215 -3.58304  1.000 14.60111 ? 326 ALA   A O   1 
ATOM   2499 C CB  . ALA   A 1 347 ? -13.05625 -21.20297 -5.40409  1.000 12.37098 ? 326 ALA   A CB  1 
ATOM   2500 N N   . GLU   A 1 348 ? -10.25945 -19.98947 -4.44699  1.000 9.94878  ? 327 GLU   A N   1 
ATOM   2501 C CA  . GLU   A 1 348 ? -8.81389  -20.10376 -4.63901  1.000 9.22840  ? 327 GLU   A CA  1 
ATOM   2502 C C   . GLU   A 1 348 ? -8.05651  -20.11119 -3.31355  1.000 14.31659 ? 327 GLU   A C   1 
ATOM   2503 O O   . GLU   A 1 348 ? -7.15300  -20.93087 -3.11157  1.000 10.49134 ? 327 GLU   A O   1 
ATOM   2504 C CB  . GLU   A 1 348 ? -8.31219  -18.96306 -5.52617  1.000 13.22795 ? 327 GLU   A CB  1 
ATOM   2505 C CG  . GLU   A 1 348 ? -8.67051  -19.11724 -6.99411  1.000 13.62993 ? 327 GLU   A CG  1 
ATOM   2506 C CD  . GLU   A 1 348 ? -8.71008  -17.79270 -7.73114  1.000 16.08681 ? 327 GLU   A CD  1 
ATOM   2507 O OE1 . GLU   A 1 348 ? -8.28501  -16.76904 -7.15485  1.000 15.45187 ? 327 GLU   A OE1 1 
ATOM   2508 O OE2 . GLU   A 1 348 ? -9.18916  -17.77287 -8.88351  1.000 19.33904 ? 327 GLU   A OE2 1 
ATOM   2509 N N   . VAL   A 1 349 ? -8.38282  -19.18501 -2.40811  1.000 11.72896 ? 328 VAL   A N   1 
ATOM   2510 C CA  . VAL   A 1 349 ? -7.61407  -18.99970 -1.18225  1.000 10.78236 ? 328 VAL   A CA  1 
ATOM   2511 C C   . VAL   A 1 349 ? -8.48276  -18.93135 0.06385   1.000 9.18629  ? 328 VAL   A C   1 
ATOM   2512 O O   . VAL   A 1 349 ? -7.95334  -18.73178 1.15908   1.000 11.91360 ? 328 VAL   A O   1 
ATOM   2513 C CB  . VAL   A 1 349 ? -6.71063  -17.74811 -1.26276  1.000 8.57791  ? 328 VAL   A CB  1 
ATOM   2514 C CG1 . VAL   A 1 349 ? -5.70799  -17.87059 -2.40787  1.000 12.56995 ? 328 VAL   A CG1 1 
ATOM   2515 C CG2 . VAL   A 1 349 ? -7.54876  -16.48502 -1.41102  1.000 12.29890 ? 328 VAL   A CG2 1 
ATOM   2516 N N   . GLY   A 1 350 ? -9.79914  -19.09552 -0.05649  1.000 8.14837  ? 329 GLY   A N   1 
ATOM   2517 C CA  . GLY   A 1 350 ? -10.63996 -18.98093 1.12117   1.000 7.35006  ? 329 GLY   A CA  1 
ATOM   2518 C C   . GLY   A 1 350 ? -10.78449 -17.53567 1.57677   1.000 8.41524  ? 329 GLY   A C   1 
ATOM   2519 O O   . GLY   A 1 350 ? -10.50602 -16.58565 0.84152   1.000 11.90619 ? 329 GLY   A O   1 
ATOM   2520 N N   . ASN   A 1 351 ? -11.23888 -17.37826 2.82043   1.000 8.27200  ? 330 ASN   A N   1 
ATOM   2521 C CA  . ASN   A 1 351 ? -11.39553 -16.05661 3.42968   1.000 10.28124 ? 330 ASN   A CA  1 
ATOM   2522 C C   . ASN   A 1 351 ? -10.10083 -15.74804 4.17375   1.000 6.90883  ? 330 ASN   A C   1 
ATOM   2523 O O   . ASN   A 1 351 ? -9.83706  -16.30215 5.24367   1.000 7.98743  ? 330 ASN   A O   1 
ATOM   2524 C CB  . ASN   A 1 351 ? -12.61111 -16.02666 4.35292   1.000 11.59234 ? 330 ASN   A CB  1 
ATOM   2525 C CG  . ASN   A 1 351 ? -12.94089 -14.62649 4.86613   1.000 9.55661  ? 330 ASN   A CG  1 
ATOM   2526 O OD1 . ASN   A 1 351 ? -12.06845 -13.76709 4.99446   1.000 6.95556  ? 330 ASN   A OD1 1 
ATOM   2527 N ND2 . ASN   A 1 351 ? -14.21284 -14.40100 5.17271   1.000 12.66883 ? 330 ASN   A ND2 1 
ATOM   2528 N N   . ILE   A 1 352 ? -9.28124  -14.86657 3.60003   1.000 7.84783  ? 331 ILE   A N   1 
ATOM   2529 C CA  . ILE   A 1 352 ? -8.00550  -14.49246 4.20273   1.000 7.08194  ? 331 ILE   A CA  1 
ATOM   2530 C C   . ILE   A 1 352 ? -8.15576  -13.14260 4.89285   1.000 7.99980  ? 331 ILE   A C   1 
ATOM   2531 O O   . ILE   A 1 352 ? -7.19340  -12.37394 5.00539   1.000 7.77394  ? 331 ILE   A O   1 
ATOM   2532 C CB  . ILE   A 1 352 ? -6.86419  -14.48605 3.16686   1.000 7.25834  ? 331 ILE   A CB  1 
ATOM   2533 C CG1 . ILE   A 1 352 ? -7.15330  -13.51583 2.02120   1.000 6.68951  ? 331 ILE   A CG1 1 
ATOM   2534 C CG2 . ILE   A 1 352 ? -6.61265  -15.89450 2.64510   1.000 8.38239  ? 331 ILE   A CG2 1 
ATOM   2535 C CD1 . ILE   A 1 352 ? -5.96604  -13.28130 1.10468   1.000 6.34122  ? 331 ILE   A CD1 1 
ATOM   2536 N N   . SER   A 1 353 ? -9.37904  -12.83545 5.31714   1.000 6.20354  ? 332 SER   A N   1 
ATOM   2537 C CA  . SER   A 1 353 ? -9.67687  -11.73301 6.24269   1.000 9.17798  ? 332 SER   A CA  1 
ATOM   2538 C C   . SER   A 1 353 ? -9.28393  -10.41252 5.58276   1.000 7.50682  ? 332 SER   A C   1 
ATOM   2539 O O   . SER   A 1 353 ? -9.63966  -10.19246 4.41462   1.000 7.44397  ? 332 SER   A O   1 
ATOM   2540 C CB  . SER   A 1 353 ? -9.00326  -12.02673 7.57904   1.000 11.94530 ? 332 SER   A CB  1 
ATOM   2541 O OG  . SER   A 1 353 ? -9.40910  -11.10103 8.57217   1.000 11.72736 ? 332 SER   A OG  1 
ATOM   2542 N N   . SER   A 1 354 ? -8.55248  -9.52968  6.26850   1.000 6.99665  ? 333 SER   A N   1 
ATOM   2543 C CA  . SER   A 1 354 ? -8.30753  -8.18225  5.76052   1.000 8.27499  ? 333 SER   A CA  1 
ATOM   2544 C C   . SER   A 1 354 ? -7.54733  -8.19364  4.44324   1.000 7.03834  ? 333 SER   A C   1 
ATOM   2545 O O   . SER   A 1 354 ? -7.64140  -7.23875  3.66338   1.000 8.14399  ? 333 SER   A O   1 
ATOM   2546 C CB  . SER   A 1 354 ? -7.52916  -7.37495  6.79635   1.000 7.55375  ? 333 SER   A CB  1 
ATOM   2547 O OG  . SER   A 1 354 ? -6.31945  -8.03268  7.12726   1.000 8.12555  ? 333 SER   A OG  1 
ATOM   2548 N N   . ALA   A 1 355 ? -6.78776  -9.25325  4.18272   1.000 6.43108  ? 334 ALA   A N   1 
ATOM   2549 C CA  . ALA   A 1 355 ? -5.98366  -9.34552  2.97462   1.000 7.87061  ? 334 ALA   A CA  1 
ATOM   2550 C C   . ALA   A 1 355 ? -6.79543  -9.68367  1.73077   1.000 5.89136  ? 334 ALA   A C   1 
ATOM   2551 O O   . ALA   A 1 355 ? -6.27088  -9.53792  0.62276   1.000 7.94089  ? 334 ALA   A O   1 
ATOM   2552 C CB  . ALA   A 1 355 ? -4.88506  -10.39442 3.16185   1.000 6.11473  ? 334 ALA   A CB  1 
ATOM   2553 N N   . THR   A 1 356 ? -8.05264  -10.11309 1.87945   1.000 4.35854  ? 335 THR   A N   1 
ATOM   2554 C CA  . THR   A 1 356 ? -8.77865  -10.68167 0.74552   1.000 6.83648  ? 335 THR   A CA  1 
ATOM   2555 C C   . THR   A 1 356 ? -8.99978  -9.65075  -0.35937  1.000 7.03336  ? 335 THR   A C   1 
ATOM   2556 O O   . THR   A 1 356 ? -8.70005  -9.91243  -1.52910  1.000 7.88335  ? 335 THR   A O   1 
ATOM   2557 C CB  . THR   A 1 356 ? -10.10969 -11.27725 1.21288   1.000 8.65524  ? 335 THR   A CB  1 
ATOM   2558 O OG1 . THR   A 1 356 ? -9.90113  -12.06297 2.39518   1.000 5.95708  ? 335 THR   A OG1 1 
ATOM   2559 C CG2 . THR   A 1 356 ? -10.68972 -12.17449 0.13577   1.000 9.12780  ? 335 THR   A CG2 1 
ATOM   2560 N N   . VAL   A 1 357 ? -9.50797  -8.46402  -0.00940  1.000 8.07604  ? 336 VAL   A N   1 
ATOM   2561 C CA  . VAL   A 1 357 ? -9.77975  -7.45659  -1.03524  1.000 5.99438  ? 336 VAL   A CA  1 
ATOM   2562 C C   . VAL   A 1 357 ? -8.49711  -6.99991  -1.71822  1.000 7.63533  ? 336 VAL   A C   1 
ATOM   2563 O O   . VAL   A 1 357 ? -8.52590  -6.58813  -2.88284  1.000 9.72246  ? 336 VAL   A O   1 
ATOM   2564 C CB  . VAL   A 1 357 ? -10.54690 -6.25487  -0.45152  1.000 7.94631  ? 336 VAL   A CB  1 
ATOM   2565 C CG1 . VAL   A 1 357 ? -11.91621 -6.67937  0.03323   1.000 11.09736 ? 336 VAL   A CG1 1 
ATOM   2566 C CG2 . VAL   A 1 357 ? -9.75582  -5.60600  0.66505   1.000 13.01617 ? 336 VAL   A CG2 1 
ATOM   2567 N N   . LEU   A 1 358 ? -7.36194  -7.02691  -1.01417  1.000 5.15570  ? 337 LEU   A N   1 
ATOM   2568 C CA  . LEU   A 1 358 ? -6.10333  -6.68024  -1.66851  1.000 7.03743  ? 337 LEU   A CA  1 
ATOM   2569 C C   . LEU   A 1 358 ? -5.70772  -7.74137  -2.68586  1.000 8.28392  ? 337 LEU   A C   1 
ATOM   2570 O O   . LEU   A 1 358 ? -5.20161  -7.41770  -3.76733  1.000 9.78722  ? 337 LEU   A O   1 
ATOM   2571 C CB  . LEU   A 1 358 ? -4.99949  -6.47967  -0.62966  1.000 7.63592  ? 337 LEU   A CB  1 
ATOM   2572 C CG  . LEU   A 1 358 ? -5.32646  -5.49590  0.49616   1.000 8.83028  ? 337 LEU   A CG  1 
ATOM   2573 C CD1 . LEU   A 1 358 ? -4.10226  -5.25911  1.36866   1.000 11.83402 ? 337 LEU   A CD1 1 
ATOM   2574 C CD2 . LEU   A 1 358 ? -5.82330  -4.18359  -0.08162  1.000 14.26776 ? 337 LEU   A CD2 1 
ATOM   2575 N N   . TYR   A 1 359 ? -5.93694  -9.01337  -2.35568  1.000 5.08488  ? 338 TYR   A N   1 
ATOM   2576 C CA  . TYR   A 1 359 ? -5.71936  -10.08730 -3.31755  1.000 8.90791  ? 338 TYR   A CA  1 
ATOM   2577 C C   . TYR   A 1 359 ? -6.63103  -9.91982  -4.52699  1.000 8.40981  ? 338 TYR   A C   1 
ATOM   2578 O O   . TYR   A 1 359 ? -6.19588  -10.09212 -5.67126  1.000 12.88868 ? 338 TYR   A O   1 
ATOM   2579 C CB  . TYR   A 1 359 ? -5.94468  -11.43550 -2.62490  1.000 10.17532 ? 338 TYR   A CB  1 
ATOM   2580 C CG  . TYR   A 1 359 ? -6.01059  -12.66150 -3.51737  1.000 11.93812 ? 338 TYR   A CG  1 
ATOM   2581 C CD1 . TYR   A 1 359 ? -7.17717  -12.99730 -4.20090  1.000 13.52200 ? 338 TYR   A CD1 1 
ATOM   2582 C CD2 . TYR   A 1 359 ? -4.91537  -13.50398 -3.64509  1.000 12.09106 ? 338 TYR   A CD2 1 
ATOM   2583 C CE1 . TYR   A 1 359 ? -7.23750  -14.12170 -5.00406  1.000 12.15813 ? 338 TYR   A CE1 1 
ATOM   2584 C CE2 . TYR   A 1 359 ? -4.96697  -14.62847 -4.44457  1.000 14.54859 ? 338 TYR   A CE2 1 
ATOM   2585 C CZ  . TYR   A 1 359 ? -6.12826  -14.93357 -5.11993  1.000 15.58622 ? 338 TYR   A CZ  1 
ATOM   2586 O OH  . TYR   A 1 359 ? -6.17516  -16.05701 -5.91168  1.000 12.36570 ? 338 TYR   A OH  1 
ATOM   2587 N N   . MET   A 1 360 ? -7.90045  -9.57503  -4.29274  1.000 10.20099 ? 339 MET   A N   1 
ATOM   2588 C CA  . MET   A 1 360 ? -8.82091  -9.34677  -5.40287  1.000 9.32976  ? 339 MET   A CA  1 
ATOM   2589 C C   . MET   A 1 360 ? -8.41486  -8.13350  -6.23222  1.000 13.71732 ? 339 MET   A C   1 
ATOM   2590 O O   . MET   A 1 360 ? -8.47846  -8.17702  -7.46663  1.000 9.26396  ? 339 MET   A O   1 
ATOM   2591 C CB  . MET   A 1 360 ? -10.25102 -9.19034  -4.88623  1.000 11.98405 ? 339 MET   A CB  1 
ATOM   2592 C CG  . MET   A 1 360 ? -10.74826 -10.34638 -4.04052  1.000 10.58025 ? 339 MET   A CG  1 
ATOM   2593 S SD  . MET   A 1 360 ? -12.29153 -9.95893  -3.19146  1.000 9.78285  ? 339 MET   A SD  1 
ATOM   2594 C CE  . MET   A 1 360 ? -13.43086 -9.86128  -4.57110  1.000 8.41393  ? 339 MET   A CE  1 
ATOM   2595 N N   . LEU   A 1 361 ? -8.00463  -7.03939  -5.57977  1.000 7.69050  ? 340 LEU   A N   1 
ATOM   2596 C CA  . LEU   A 1 361 ? -7.55266  -5.86963  -6.33026  1.000 8.77166  ? 340 LEU   A CA  1 
ATOM   2597 C C   . LEU   A 1 361 ? -6.31956  -6.20197  -7.15694  1.000 11.99372 ? 340 LEU   A C   1 
ATOM   2598 O O   . LEU   A 1 361 ? -6.16167  -5.71134  -8.28163  1.000 11.30446 ? 340 LEU   A O   1 
ATOM   2599 C CB  . LEU   A 1 361 ? -7.26207  -4.70179  -5.38519  1.000 12.25008 ? 340 LEU   A CB  1 
ATOM   2600 C CG  . LEU   A 1 361 ? -6.72416  -3.43201  -6.05434  1.000 10.66810 ? 340 LEU   A CG  1 
ATOM   2601 C CD1 . LEU   A 1 361 ? -7.76924  -2.81774  -6.97830  1.000 15.73485 ? 340 LEU   A CD1 1 
ATOM   2602 C CD2 . LEU   A 1 361 ? -6.25012  -2.41777  -5.02296  1.000 13.11830 ? 340 LEU   A CD2 1 
ATOM   2603 N N   . ASP   A 1 362 ? -5.43896  -7.04217  -6.61064  1.000 11.95240 ? 341 ASP   A N   1 
ATOM   2604 C CA  . ASP   A 1 362 ? -4.27484  -7.51270  -7.35351  1.000 11.97628 ? 341 ASP   A CA  1 
ATOM   2605 C C   . ASP   A 1 362 ? -4.67798  -8.28032  -8.60644  1.000 14.40927 ? 341 ASP   A C   1 
ATOM   2606 O O   . ASP   A 1 362 ? -4.06204  -8.11643  -9.66662  1.000 10.68180 ? 341 ASP   A O   1 
ATOM   2607 C CB  . ASP   A 1 362 ? -3.40765  -8.38404  -6.44750  1.000 10.00380 ? 341 ASP   A CB  1 
ATOM   2608 C CG  . ASP   A 1 362 ? -2.15466  -8.86791  -7.13574  1.000 11.60039 ? 341 ASP   A CG  1 
ATOM   2609 O OD1 . ASP   A 1 362 ? -1.22579  -8.05742  -7.33307  1.000 12.93152 ? 341 ASP   A OD1 1 
ATOM   2610 O OD2 . ASP   A 1 362 ? -2.10732  -10.06639 -7.48461  1.000 7.49669  ? 341 ASP   A OD2 1 
ATOM   2611 N N   . LYS   A 1 363 ? -5.69592  -9.13820  -8.50334  1.000 10.82572 ? 342 LYS   A N   1 
ATOM   2612 C CA  . LYS   A 1 363 ? -6.17026  -9.85187  -9.68589  1.000 20.32161 ? 342 LYS   A CA  1 
ATOM   2613 C C   . LYS   A 1 363 ? -6.69829  -8.88457  -10.73802 1.000 12.68687 ? 342 LYS   A C   1 
ATOM   2614 O O   . LYS   A 1 363 ? -6.45165  -9.06152  -11.93746 1.000 15.04864 ? 342 LYS   A O   1 
ATOM   2615 C CB  . LYS   A 1 363 ? -7.25009  -10.86277 -9.29776  1.000 13.63002 ? 342 LYS   A CB  1 
ATOM   2616 C CG  . LYS   A 1 363 ? -6.74397  -12.01238 -8.44960  1.000 19.02646 ? 342 LYS   A CG  1 
ATOM   2617 C CD  . LYS   A 1 363 ? -6.28288  -13.16276 -9.32588  1.000 18.82922 ? 342 LYS   A CD  1 
ATOM   2618 C CE  . LYS   A 1 363 ? -5.59655  -14.23980 -8.51151  1.000 18.81612 ? 342 LYS   A CE  1 
ATOM   2619 N NZ  . LYS   A 1 363 ? -4.88131  -15.21266 -9.38096  1.000 30.48202 ? 342 LYS   A NZ  1 
ATOM   2620 N N   . VAL   A 1 364 ? -7.42296  -7.85278  -10.30538 1.000 12.76153 ? 343 VAL   A N   1 
ATOM   2621 C CA  . VAL   A 1 364 ? -8.01131  -6.90083  -11.24260 1.000 17.41304 ? 343 VAL   A CA  1 
ATOM   2622 C C   . VAL   A 1 364 ? -6.92690  -6.12129  -11.97572 1.000 16.29956 ? 343 VAL   A C   1 
ATOM   2623 O O   . VAL   A 1 364 ? -6.97795  -5.95711  -13.20022 1.000 13.21774 ? 343 VAL   A O   1 
ATOM   2624 C CB  . VAL   A 1 364 ? -8.97484  -5.95797  -10.50416 1.000 14.61924 ? 343 VAL   A CB  1 
ATOM   2625 C CG1 . VAL   A 1 364 ? -9.37927  -4.80748  -11.40717 1.000 16.86036 ? 343 VAL   A CG1 1 
ATOM   2626 C CG2 . VAL   A 1 364 ? -10.19261 -6.72850  -10.02660 1.000 17.12419 ? 343 VAL   A CG2 1 
ATOM   2627 N N   . LEU   A 1 365 ? -5.93490  -5.62214  -11.23570 1.000 16.97956 ? 344 LEU   A N   1 
ATOM   2628 C CA  . LEU   A 1 365 ? -4.90512  -4.78290  -11.83850 1.000 13.88811 ? 344 LEU   A CA  1 
ATOM   2629 C C   . LEU   A 1 365 ? -3.95514  -5.58908  -12.71351 1.000 19.66025 ? 344 LEU   A C   1 
ATOM   2630 O O   . LEU   A 1 365 ? -3.37110  -5.04357  -13.65620 1.000 21.40414 ? 344 LEU   A O   1 
ATOM   2631 C CB  . LEU   A 1 365 ? -4.11745  -4.05467  -10.74783 1.000 15.05673 ? 344 LEU   A CB  1 
ATOM   2632 C CG  . LEU   A 1 365 ? -4.89092  -3.12257  -9.81473  1.000 17.49038 ? 344 LEU   A CG  1 
ATOM   2633 C CD1 . LEU   A 1 365 ? -3.93318  -2.29331  -8.97035  1.000 18.33589 ? 344 LEU   A CD1 1 
ATOM   2634 C CD2 . LEU   A 1 365 ? -5.82584  -2.22264  -10.60709 1.000 20.52210 ? 344 LEU   A CD2 1 
ATOM   2635 N N   . SER   A 1 366 ? -3.78165  -6.87626  -12.42319 1.000 17.60795 ? 345 SER   A N   1 
ATOM   2636 C CA  . SER   A 1 366 ? -2.78038  -7.67350  -13.11857 1.000 28.56697 ? 345 SER   A CA  1 
ATOM   2637 C C   . SER   A 1 366 ? -3.34970  -8.54465  -14.22837 1.000 25.20699 ? 345 SER   A C   1 
ATOM   2638 O O   . SER   A 1 366 ? -2.62637  -8.85854  -15.17860 1.000 30.20024 ? 345 SER   A O   1 
ATOM   2639 C CB  . SER   A 1 366 ? -2.02650  -8.56255  -12.12299 1.000 24.54106 ? 345 SER   A CB  1 
ATOM   2640 O OG  . SER   A 1 366 ? -2.84830  -9.61904  -11.65781 1.000 32.47914 ? 345 SER   A OG  1 
ATOM   2641 N N   . GLU   A 1 367 ? -4.62103  -8.94083  -14.14695 1.000 26.10661 ? 346 GLU   A N   1 
ATOM   2642 C CA  . GLU   A 1 367 ? -5.16450  -9.92283  -15.07264 1.000 22.85026 ? 346 GLU   A CA  1 
ATOM   2643 C C   . GLU   A 1 367 ? -6.36485  -9.45011  -15.87967 1.000 33.35750 ? 346 GLU   A C   1 
ATOM   2644 O O   . GLU   A 1 367 ? -6.75091  -10.14264 -16.82855 1.000 41.76333 ? 346 GLU   A O   1 
ATOM   2645 C CB  . GLU   A 1 367 ? -5.56346  -11.20440 -14.32249 1.000 31.31421 ? 346 GLU   A CB  1 
ATOM   2646 C CG  . GLU   A 1 367 ? -4.44616  -11.83519 -13.51021 1.000 33.51853 ? 346 GLU   A CG  1 
ATOM   2647 C CD  . GLU   A 1 367 ? -4.79011  -13.23627 -13.04553 1.000 32.89865 ? 346 GLU   A CD  1 
ATOM   2648 O OE1 . GLU   A 1 367 ? -5.98643  -13.59487 -13.06781 1.000 38.86961 ? 346 GLU   A OE1 1 
ATOM   2649 O OE2 . GLU   A 1 367 ? -3.86582  -13.97633 -12.64890 1.000 53.06646 ? 346 GLU   A OE2 1 
ATOM   2650 N N   . GLU   A 1 368 ? -6.96893  -8.31425  -15.54713 1.000 25.66575 ? 347 GLU   A N   1 
ATOM   2651 C CA  . GLU   A 1 368 ? -8.18492  -7.88809  -16.22006 1.000 32.17264 ? 347 GLU   A CA  1 
ATOM   2652 C C   . GLU   A 1 368 ? -7.99257  -6.54091  -16.90270 1.000 35.01362 ? 347 GLU   A C   1 
ATOM   2653 O O   . GLU   A 1 368 ? -7.11393  -5.75119  -16.54460 1.000 30.89519 ? 347 GLU   A O   1 
ATOM   2654 C CB  . GLU   A 1 368 ? -9.36755  -7.81582  -15.24469 1.000 29.31531 ? 347 GLU   A CB  1 
ATOM   2655 C CG  . GLU   A 1 368 ? -9.50251  -9.03462  -14.35481 1.000 28.19221 ? 347 GLU   A CG  1 
ATOM   2656 C CD  . GLU   A 1 368 ? -10.84360 -9.09123  -13.66076 1.000 38.53263 ? 347 GLU   A CD  1 
ATOM   2657 O OE1 . GLU   A 1 368 ? -11.45899 -8.02149  -13.47001 1.000 41.28487 ? 347 GLU   A OE1 1 
ATOM   2658 O OE2 . GLU   A 1 368 ? -11.28513 -10.20557 -13.31024 1.000 44.57848 ? 347 GLU   A OE2 1 
ATOM   2659 N N   . GLN   A 1 369 ? -8.83040  -6.30616  -17.91162 1.000 36.44659 ? 348 GLN   A N   1 
ATOM   2660 C CA  . GLN   A 1 369 ? -8.86730  -5.04508  -18.64093 1.000 35.60021 ? 348 GLN   A CA  1 
ATOM   2661 C C   . GLN   A 1 369 ? -9.91336  -4.13627  -18.00409 1.000 33.21212 ? 348 GLN   A C   1 
ATOM   2662 O O   . GLN   A 1 369 ? -11.08261 -4.51841  -17.87956 1.000 35.24945 ? 348 GLN   A O   1 
ATOM   2663 C CB  . GLN   A 1 369 ? -9.19957  -5.28062  -20.11459 1.000 44.81643 ? 348 GLN   A CB  1 
ATOM   2664 C CG  . GLN   A 1 369 ? -8.02701  -5.22135  -21.08511 1.000 48.65016 ? 348 GLN   A CG  1 
ATOM   2665 C CD  . GLN   A 1 369 ? -8.40838  -5.76101  -22.45433 1.000 50.93481 ? 348 GLN   A CD  1 
ATOM   2666 O OE1 . GLN   A 1 369 ? -9.45774  -6.38814  -22.61221 1.000 53.48386 ? 348 GLN   A OE1 1 
ATOM   2667 N NE2 . GLN   A 1 369 ? -7.56449  -5.51254  -23.45210 1.000 44.00464 ? 348 GLN   A NE2 1 
ATOM   2668 N N   . SER   A 1 370 ? -9.49351  -2.94442  -17.59209 1.000 30.73067 ? 349 SER   A N   1 
ATOM   2669 C CA  . SER   A 1 370 ? -10.41032 -1.95922  -17.02941 1.000 31.58064 ? 349 SER   A CA  1 
ATOM   2670 C C   . SER   A 1 370 ? -10.60239 -0.83240  -18.03154 1.000 22.20515 ? 349 SER   A C   1 
ATOM   2671 O O   . SER   A 1 370 ? -9.63851  -0.10790  -18.32631 1.000 23.09333 ? 349 SER   A O   1 
ATOM   2672 C CB  . SER   A 1 370 ? -9.87903  -1.41170  -15.70330 1.000 28.23543 ? 349 SER   A CB  1 
ATOM   2673 O OG  . SER   A 1 370 ? -9.56255  -2.46521  -14.80991 1.000 25.88391 ? 349 SER   A OG  1 
ATOM   2674 N N   . PRO   A 1 371 ? -11.79813 -0.65347  -18.58873 1.000 24.69598 ? 350 PRO   A N   1 
ATOM   2675 C CA  . PRO   A 1 371 ? -12.00845 0.39923   -19.59095 1.000 18.13060 ? 350 PRO   A CA  1 
ATOM   2676 C C   . PRO   A 1 371 ? -11.65453 1.76495   -19.03466 1.000 18.35233 ? 350 PRO   A C   1 
ATOM   2677 O O   . PRO   A 1 371 ? -11.88377 2.04316   -17.84701 1.000 17.62339 ? 350 PRO   A O   1 
ATOM   2678 C CB  . PRO   A 1 371 ? -13.51077 0.30708   -19.91088 1.000 21.83857 ? 350 PRO   A CB  1 
ATOM   2679 C CG  . PRO   A 1 371 ? -14.06087 -0.79529  -19.06714 1.000 25.37747 ? 350 PRO   A CG  1 
ATOM   2680 C CD  . PRO   A 1 371 ? -12.92950 -1.58858  -18.51690 1.000 21.02323 ? 350 PRO   A CD  1 
ATOM   2681 N N   . PRO   A 1 372 ? -11.07723 2.63566   -19.85904 1.000 18.29202 ? 351 PRO   A N   1 
ATOM   2682 C CA  . PRO   A 1 372 ? -10.72892 3.97941   -19.38674 1.000 22.57014 ? 351 PRO   A CA  1 
ATOM   2683 C C   . PRO   A 1 372 ? -11.95040 4.72674   -18.87234 1.000 17.09031 ? 351 PRO   A C   1 
ATOM   2684 O O   . PRO   A 1 372 ? -13.04339 4.63475   -19.43601 1.000 20.20868 ? 351 PRO   A O   1 
ATOM   2685 C CB  . PRO   A 1 372 ? -10.14512 4.64968   -20.63482 1.000 24.62975 ? 351 PRO   A CB  1 
ATOM   2686 C CG  . PRO   A 1 372 ? -9.61755  3.51855   -21.45168 1.000 25.39287 ? 351 PRO   A CG  1 
ATOM   2687 C CD  . PRO   A 1 372 ? -10.54143 2.35926   -21.20348 1.000 22.30275 ? 351 PRO   A CD  1 
ATOM   2688 N N   . ASP   A 1 373 ? -11.74770 5.46174   -17.77799 1.000 19.30912 ? 352 ASP   A N   1 
ATOM   2689 C CA  . ASP   A 1 373 ? -12.75875 6.29936   -17.13996 1.000 18.47393 ? 352 ASP   A CA  1 
ATOM   2690 C C   . ASP   A 1 373 ? -13.91571 5.49826   -16.55372 1.000 17.90138 ? 352 ASP   A C   1 
ATOM   2691 O O   . ASP   A 1 373 ? -14.96411 6.07001   -16.23907 1.000 19.45436 ? 352 ASP   A O   1 
ATOM   2692 C CB  . ASP   A 1 373 ? -13.29666 7.35954   -18.10922 1.000 33.26521 ? 352 ASP   A CB  1 
ATOM   2693 C CG  . ASP   A 1 373 ? -12.31534 8.49367   -18.33302 1.000 41.70493 ? 352 ASP   A CG  1 
ATOM   2694 O OD1 . ASP   A 1 373 ? -11.64662 8.50184   -19.38887 1.000 45.27704 ? 352 ASP   A OD1 1 
ATOM   2695 O OD2 . ASP   A 1 373 ? -12.20558 9.37011   -17.45040 1.000 45.71333 ? 352 ASP   A OD2 1 
ATOM   2696 N N   . SER   A 1 374 ? -13.75771 4.18709   -16.39119 1.000 16.27120 ? 353 SER   A N   1 
ATOM   2697 C CA  . SER   A 1 374 ? -14.80314 3.39803   -15.76136 1.000 15.30577 ? 353 SER   A CA  1 
ATOM   2698 C C   . SER   A 1 374 ? -14.68375 3.48412   -14.24284 1.000 15.46424 ? 353 SER   A C   1 
ATOM   2699 O O   . SER   A 1 374 ? -13.64657 3.86339   -13.69369 1.000 12.68443 ? 353 SER   A O   1 
ATOM   2700 C CB  . SER   A 1 374 ? -14.73944 1.93652   -16.20755 1.000 11.39515 ? 353 SER   A CB  1 
ATOM   2701 O OG  . SER   A 1 374 ? -13.47534 1.36494   -15.92436 1.000 16.04509 ? 353 SER   A OG  1 
ATOM   2702 N N   . TYR   A 1 375 ? -15.76324 3.11616   -13.56325 1.000 10.78005 ? 354 TYR   A N   1 
ATOM   2703 C CA  . TYR   A 1 375 ? -15.83617 3.20406   -12.11343 1.000 11.43818 ? 354 TYR   A CA  1 
ATOM   2704 C C   . TYR   A 1 375 ? -15.76508 1.82137   -11.48237 1.000 11.63715 ? 354 TYR   A C   1 
ATOM   2705 O O   . TYR   A 1 375 ? -16.31768 0.85296   -12.01255 1.000 7.55519  ? 354 TYR   A O   1 
ATOM   2706 C CB  . TYR   A 1 375 ? -17.12115 3.90497   -11.66923 1.000 11.97347 ? 354 TYR   A CB  1 
ATOM   2707 C CG  . TYR   A 1 375 ? -17.11679 5.39048   -11.92534 1.000 11.60938 ? 354 TYR   A CG  1 
ATOM   2708 C CD1 . TYR   A 1 375 ? -16.44495 6.25579   -11.07558 1.000 13.86838 ? 354 TYR   A CD1 1 
ATOM   2709 C CD2 . TYR   A 1 375 ? -17.78693 5.92956   -13.01387 1.000 11.36237 ? 354 TYR   A CD2 1 
ATOM   2710 C CE1 . TYR   A 1 375 ? -16.43780 7.61632   -11.30384 1.000 18.40159 ? 354 TYR   A CE1 1 
ATOM   2711 C CE2 . TYR   A 1 375 ? -17.78426 7.28798   -13.25077 1.000 12.78872 ? 354 TYR   A CE2 1 
ATOM   2712 C CZ  . TYR   A 1 375 ? -17.10793 8.12768   -12.39265 1.000 23.41614 ? 354 TYR   A CZ  1 
ATOM   2713 O OH  . TYR   A 1 375 ? -17.10053 9.48450   -12.61999 1.000 30.19712 ? 354 TYR   A OH  1 
ATOM   2714 N N   . GLY   A 1 376 ? -15.07887 1.74540   -10.34083 1.000 9.75021  ? 355 GLY   A N   1 
ATOM   2715 C CA  . GLY   A 1 376 ? -15.05432 0.54135   -9.54701  1.000 8.22204  ? 355 GLY   A CA  1 
ATOM   2716 C C   . GLY   A 1 376 ? -15.34135 0.86673   -8.09427  1.000 8.93844  ? 355 GLY   A C   1 
ATOM   2717 O O   . GLY   A 1 376 ? -15.16321 1.99689   -7.63801  1.000 8.33731  ? 355 GLY   A O   1 
ATOM   2718 N N   . LEU   A 1 377 ? -15.80248 -0.15037  -7.36983  1.000 6.57991  ? 356 LEU   A N   1 
ATOM   2719 C CA  . LEU   A 1 377 ? -16.16121 0.00126   -5.96577  1.000 3.31027  ? 356 LEU   A CA  1 
ATOM   2720 C C   . LEU   A 1 377 ? -15.58157 -1.15273  -5.16383  1.000 6.55805  ? 356 LEU   A C   1 
ATOM   2721 O O   . LEU   A 1 377 ? -15.89671 -2.31708  -5.43048  1.000 6.31131  ? 356 LEU   A O   1 
ATOM   2722 C CB  . LEU   A 1 377 ? -17.68210 0.06170   -5.78846  1.000 5.85680  ? 356 LEU   A CB  1 
ATOM   2723 C CG  . LEU   A 1 377 ? -18.19406 0.41888   -4.38944  1.000 8.84907  ? 356 LEU   A CG  1 
ATOM   2724 C CD1 . LEU   A 1 377 ? -17.90123 1.87527   -4.05707  1.000 6.92018  ? 356 LEU   A CD1 1 
ATOM   2725 C CD2 . LEU   A 1 377 ? -19.68283 0.12539   -4.28705  1.000 9.91843  ? 356 LEU   A CD2 1 
ATOM   2726 N N   . ILE   A 1 378 ? -14.74593 -0.82618  -4.17931  1.000 5.09306  ? 357 ILE   A N   1 
ATOM   2727 C CA  . ILE   A 1 378 ? -14.28241 -1.78956  -3.18745  1.000 4.62920  ? 357 ILE   A CA  1 
ATOM   2728 C C   . ILE   A 1 378 ? -15.24483 -1.74837  -2.00984  1.000 7.02593  ? 357 ILE   A C   1 
ATOM   2729 O O   . ILE   A 1 378 ? -15.56713 -0.66847  -1.50375  1.000 4.96072  ? 357 ILE   A O   1 
ATOM   2730 C CB  . ILE   A 1 378 ? -12.84960 -1.46992  -2.73074  1.000 5.08279  ? 357 ILE   A CB  1 
ATOM   2731 C CG1 . ILE   A 1 378 ? -11.88322 -1.49167  -3.91513  1.000 4.83450  ? 357 ILE   A CG1 1 
ATOM   2732 C CG2 . ILE   A 1 378 ? -12.39115 -2.45850  -1.66901  1.000 11.72881 ? 357 ILE   A CG2 1 
ATOM   2733 C CD1 . ILE   A 1 378 ? -10.54147 -0.88473  -3.59115  1.000 7.80476  ? 357 ILE   A CD1 1 
ATOM   2734 N N   . VAL   A 1 379 ? -15.72458 -2.91669  -1.58644  1.000 6.93086  ? 358 VAL   A N   1 
ATOM   2735 C CA  . VAL   A 1 379 ? -16.65435 -3.02999  -0.46736  1.000 4.93793  ? 358 VAL   A CA  1 
ATOM   2736 C C   . VAL   A 1 379 ? -16.16366 -4.13024  0.46037   1.000 7.72524  ? 358 VAL   A C   1 
ATOM   2737 O O   . VAL   A 1 379 ? -15.89230 -5.24813  0.01172   1.000 7.61119  ? 358 VAL   A O   1 
ATOM   2738 C CB  . VAL   A 1 379 ? -18.09033 -3.33891  -0.93512  1.000 7.23847  ? 358 VAL   A CB  1 
ATOM   2739 C CG1 . VAL   A 1 379 ? -19.01193 -3.49739  0.26302   1.000 9.25973  ? 358 VAL   A CG1 1 
ATOM   2740 C CG2 . VAL   A 1 379 ? -18.60229 -2.25375  -1.86162  1.000 6.23837  ? 358 VAL   A CG2 1 
ATOM   2741 N N   . ALA   A 1 380 ? -16.06096 -3.82245  1.75146   1.000 8.53267  ? 359 ALA   A N   1 
ATOM   2742 C CA  . ALA   A 1 380 ? -15.73199 -4.83610  2.73948   1.000 7.33614  ? 359 ALA   A CA  1 
ATOM   2743 C C   . ALA   A 1 380 ? -16.55743 -4.60108  3.99186   1.000 8.11289  ? 359 ALA   A C   1 
ATOM   2744 O O   . ALA   A 1 380 ? -16.97962 -3.47863  4.27413   1.000 8.51580  ? 359 ALA   A O   1 
ATOM   2745 C CB  . ALA   A 1 380 ? -14.23997 -4.84109  3.08844   1.000 7.85977  ? 359 ALA   A CB  1 
ATOM   2746 N N   . MET   A 1 381 ? -16.79543 -5.67882  4.73110   1.000 11.02933 ? 360 MET   A N   1 
ATOM   2747 C CA  . MET   A 1 381 ? -17.51318 -5.61690  5.99310   1.000 14.50612 ? 360 MET   A CA  1 
ATOM   2748 C C   . MET   A 1 381 ? -16.76609 -6.41306  7.05108   1.000 14.81152 ? 360 MET   A C   1 
ATOM   2749 O O   . MET   A 1 381 ? -16.12147 -7.42448  6.75948   1.000 14.13244 ? 360 MET   A O   1 
ATOM   2750 C CB  . MET   A 1 381 ? -18.96195 -6.11325  5.84777   1.000 9.50563  ? 360 MET   A CB  1 
ATOM   2751 C CG  . MET   A 1 381 ? -19.12410 -7.60068  5.56268   1.000 18.58619 ? 360 MET   A CG  1 
ATOM   2752 S SD  . MET   A 1 381 ? -18.12933 -8.14053  4.15180   1.000 21.62429 ? 360 MET   A SD  1 
ATOM   2753 C CE  . MET   A 1 381 ? -19.09687 -7.49954  2.78808   1.000 23.51187 ? 360 MET   A CE  1 
ATOM   2754 N N   . GLY   A 1 382 ? -16.84729 -5.93322  8.28510   1.000 7.82673  ? 361 GLY   A N   1 
ATOM   2755 C CA  . GLY   A 1 382 ? -16.12744 -6.54813  9.36988   1.000 9.82622  ? 361 GLY   A CA  1 
ATOM   2756 C C   . GLY   A 1 382 ? -16.75399 -6.26199  10.71440  1.000 11.28288 ? 361 GLY   A C   1 
ATOM   2757 O O   . GLY   A 1 382 ? -17.87518 -5.75121  10.81139  1.000 10.41064 ? 361 GLY   A O   1 
ATOM   2758 N N   . PRO   A 1 383 ? -16.02010 -6.56949  11.78255  1.000 9.02168  ? 362 PRO   A N   1 
ATOM   2759 C CA  . PRO   A 1 383 ? -16.56387 -6.38436  13.12944  1.000 11.81076 ? 362 PRO   A CA  1 
ATOM   2760 C C   . PRO   A 1 383 ? -16.98004 -4.94396  13.37592  1.000 9.24538  ? 362 PRO   A C   1 
ATOM   2761 O O   . PRO   A 1 383 ? -16.35717 -3.99679  12.88834  1.000 6.58240  ? 362 PRO   A O   1 
ATOM   2762 C CB  . PRO   A 1 383 ? -15.39681 -6.78599  14.03956  1.000 11.16794 ? 362 PRO   A CB  1 
ATOM   2763 C CG  . PRO   A 1 383 ? -14.59869 -7.73160  13.21680  1.000 9.51803  ? 362 PRO   A CG  1 
ATOM   2764 C CD  . PRO   A 1 383 ? -14.70218 -7.22590  11.80361  1.000 7.41753  ? 362 PRO   A CD  1 
ATOM   2765 N N   . GLY   A 1 384 ? -18.02619 -4.79834  14.18528  1.000 5.64602  ? 363 GLY   A N   1 
ATOM   2766 C CA  . GLY   A 1 384 ? -18.53138 -3.51332  14.62132  1.000 6.41905  ? 363 GLY   A CA  1 
ATOM   2767 C C   . GLY   A 1 384 ? -20.03480 -3.36369  14.79385  1.000 9.33398  ? 363 GLY   A C   1 
ATOM   2768 O O   . GLY   A 1 384 ? -20.43035 -2.79128  15.81243  1.000 6.88245  ? 363 GLY   A O   1 
ATOM   2769 N N   . LEU   A 1 385 ? -20.89900 -3.88187  13.91510  1.000 6.76944  ? 364 LEU   A N   1 
ATOM   2770 C CA  . LEU   A 1 385 ? -20.60883 -4.29449  12.54677  1.000 8.45850  ? 364 LEU   A CA  1 
ATOM   2771 C C   . LEU   A 1 385 ? -20.30743 -3.08210  11.67387  1.000 9.61849  ? 364 LEU   A C   1 
ATOM   2772 O O   . LEU   A 1 385 ? -21.05240 -2.10423  11.69007  1.000 10.55158 ? 364 LEU   A O   1 
ATOM   2773 C CB  . LEU   A 1 385 ? -21.80484 -5.05332  11.96444  1.000 9.95507  ? 364 LEU   A CB  1 
ATOM   2774 C CG  . LEU   A 1 385 ? -21.55625 -6.31463  11.14387  1.000 18.73275 ? 364 LEU   A CG  1 
ATOM   2775 C CD1 . LEU   A 1 385 ? -20.61399 -7.21805  11.89159  1.000 18.00079 ? 364 LEU   A CD1 1 
ATOM   2776 C CD2 . LEU   A 1 385 ? -22.86946 -7.02633  10.84983  1.000 25.43767 ? 364 LEU   A CD2 1 
ATOM   2777 N N   . ALA   A 1 386 ? -19.24443 -3.15378  10.87984  1.000 8.82597  ? 365 ALA   A N   1 
ATOM   2778 C CA  . ALA   A 1 386 ? -18.80775 -2.01730  10.08599  1.000 9.05327  ? 365 ALA   A CA  1 
ATOM   2779 C C   . ALA   A 1 386 ? -18.67986 -2.40849  8.62217   1.000 12.55981 ? 365 ALA   A C   1 
ATOM   2780 O O   . ALA   A 1 386 ? -18.40885 -3.56505  8.28949   1.000 8.38738  ? 365 ALA   A O   1 
ATOM   2781 C CB  . ALA   A 1 386 ? -17.46668 -1.46420  10.58793  1.000 7.53223  ? 365 ALA   A CB  1 
ATOM   2782 N N   . GLN   A 1 387 ? -18.88625 -1.42823  7.74816   1.000 8.14110  ? 366 GLN   A N   1 
ATOM   2783 C CA  . GLN   A 1 387 ? -18.66728 -1.60384  6.32160   1.000 7.34445  ? 366 GLN   A CA  1 
ATOM   2784 C C   . GLN   A 1 387 ? -17.89609 -0.41037  5.78211   1.000 7.35003  ? 366 GLN   A C   1 
ATOM   2785 O O   . GLN   A 1 387 ? -17.98544 0.70098   6.30969   1.000 9.37014  ? 366 GLN   A O   1 
ATOM   2786 C CB  . GLN   A 1 387 ? -19.98162 -1.77382  5.53535   1.000 8.65228  ? 366 GLN   A CB  1 
ATOM   2787 C CG  . GLN   A 1 387 ? -20.97097 -2.78000  6.11028   1.000 10.92547 ? 366 GLN   A CG  1 
ATOM   2788 C CD  . GLN   A 1 387 ? -21.69638 -2.26465  7.33845   1.000 18.71913 ? 366 GLN   A CD  1 
ATOM   2789 O OE1 . GLN   A 1 387 ? -22.20499 -1.14427  7.34402   1.000 21.78251 ? 366 GLN   A OE1 1 
ATOM   2790 N NE2 . GLN   A 1 387 ? -21.74765 -3.08025  8.38477   1.000 15.06820 ? 366 GLN   A NE2 1 
ATOM   2791 N N   . GLU   A 1 388 ? -17.13430 -0.65332  4.72248   1.000 9.55596  ? 367 GLU   A N   1 
ATOM   2792 C CA  . GLU   A 1 388 ? -16.29621 0.36654   4.11823   1.000 6.38878  ? 367 GLU   A CA  1 
ATOM   2793 C C   . GLU   A 1 388 ? -16.46693 0.30656   2.60883   1.000 4.43143  ? 367 GLU   A C   1 
ATOM   2794 O O   . GLU   A 1 388 ? -16.50813 -0.77935  2.02392   1.000 6.67760  ? 367 GLU   A O   1 
ATOM   2795 C CB  . GLU   A 1 388 ? -14.82708 0.16895   4.51013   1.000 4.72264  ? 367 GLU   A CB  1 
ATOM   2796 C CG  . GLU   A 1 388 ? -13.90743 1.30014   4.10170   1.000 8.51126  ? 367 GLU   A CG  1 
ATOM   2797 C CD  . GLU   A 1 388 ? -13.90213 2.43652   5.10729   1.000 10.94602 ? 367 GLU   A CD  1 
ATOM   2798 O OE1 . GLU   A 1 388 ? -14.49197 2.27825   6.19714   1.000 9.56592  ? 367 GLU   A OE1 1 
ATOM   2799 O OE2 . GLU   A 1 388 ? -13.30779 3.48886   4.80716   1.000 9.54479  ? 367 GLU   A OE2 1 
ATOM   2800 N N   . ALA   A 1 389 ? -16.59712 1.47198   1.98650   1.000 4.73905  ? 368 ALA   A N   1 
ATOM   2801 C CA  . ALA   A 1 389 ? -16.72229 1.56462   0.54002   1.000 5.46846  ? 368 ALA   A CA  1 
ATOM   2802 C C   . ALA   A 1 389 ? -15.69986 2.55414   0.00442   1.000 9.15953  ? 368 ALA   A C   1 
ATOM   2803 O O   . ALA   A 1 389 ? -15.51364 3.63595   0.57023   1.000 4.23156  ? 368 ALA   A O   1 
ATOM   2804 C CB  . ALA   A 1 389 ? -18.13703 1.98602   0.12738   1.000 3.01394  ? 368 ALA   A CB  1 
ATOM   2805 N N   . ILE   A 1 390 ? -15.03506 2.17560   -1.08555  1.000 5.41376  ? 369 ILE   A N   1 
ATOM   2806 C CA  . ILE   A 1 390 ? -14.03875 3.01676   -1.73830  1.000 6.54046  ? 369 ILE   A CA  1 
ATOM   2807 C C   . ILE   A 1 390 ? -14.41090 3.10965   -3.20720  1.000 6.13273  ? 369 ILE   A C   1 
ATOM   2808 O O   . ILE   A 1 390 ? -14.53745 2.08112   -3.88045  1.000 5.48567  ? 369 ILE   A O   1 
ATOM   2809 C CB  . ILE   A 1 390 ? -12.61589 2.45853   -1.58991  1.000 5.64194  ? 369 ILE   A CB  1 
ATOM   2810 C CG1 . ILE   A 1 390 ? -12.22853 2.37150   -0.11834  1.000 9.37918  ? 369 ILE   A CG1 1 
ATOM   2811 C CG2 . ILE   A 1 390 ? -11.62793 3.33637   -2.33969  1.000 8.21451  ? 369 ILE   A CG2 1 
ATOM   2812 C CD1 . ILE   A 1 390 ? -11.94491 0.96268   0.32233   1.000 12.04924 ? 369 ILE   A CD1 1 
ATOM   2813 N N   . LEU   A 1 391 ? -14.57811 4.32993   -3.70506  1.000 6.31720  ? 370 LEU   A N   1 
ATOM   2814 C CA  . LEU   A 1 391 ? -14.95456 4.54743   -5.09579  1.000 5.91175  ? 370 LEU   A CA  1 
ATOM   2815 C C   . LEU   A 1 391 ? -13.69658 4.77338   -5.92499  1.000 10.16122 ? 370 LEU   A C   1 
ATOM   2816 O O   . LEU   A 1 391 ? -12.89147 5.65843   -5.61328  1.000 12.13039 ? 370 LEU   A O   1 
ATOM   2817 C CB  . LEU   A 1 391 ? -15.90762 5.73477   -5.21304  1.000 8.43494  ? 370 LEU   A CB  1 
ATOM   2818 C CG  . LEU   A 1 391 ? -16.34899 6.13921   -6.61851  1.000 6.11195  ? 370 LEU   A CG  1 
ATOM   2819 C CD1 . LEU   A 1 391 ? -16.97057 4.96896   -7.36681  1.000 6.79615  ? 370 LEU   A CD1 1 
ATOM   2820 C CD2 . LEU   A 1 391 ? -17.30635 7.32942   -6.55388  1.000 8.54885  ? 370 LEU   A CD2 1 
ATOM   2821 N N   . LEU   A 1 392 ? -13.53225 3.97610   -6.97688  1.000 10.49383 ? 371 LEU   A N   1 
ATOM   2822 C CA  . LEU   A 1 392 ? -12.36420 4.02639   -7.84073  1.000 8.91246  ? 371 LEU   A CA  1 
ATOM   2823 C C   . LEU   A 1 392 ? -12.76659 4.49462   -9.23173  1.000 12.28097 ? 371 LEU   A C   1 
ATOM   2824 O O   . LEU   A 1 392 ? -13.88349 4.23906   -9.68957  1.000 13.71248 ? 371 LEU   A O   1 
ATOM   2825 C CB  . LEU   A 1 392 ? -11.69265 2.65458   -7.94568  1.000 8.65045  ? 371 LEU   A CB  1 
ATOM   2826 C CG  . LEU   A 1 392 ? -11.21170 2.00757   -6.64769  1.000 12.92203 ? 371 LEU   A CG  1 
ATOM   2827 C CD1 . LEU   A 1 392 ? -10.57604 0.65000   -6.93416  1.000 10.26509 ? 371 LEU   A CD1 1 
ATOM   2828 C CD2 . LEU   A 1 392 ? -10.25301 2.92719   -5.90515  1.000 9.09077  ? 371 LEU   A CD2 1 
ATOM   2829 N N   . LYS   A 1 393 ? -11.84774 5.18453   -9.90444  1.000 15.18081 ? 372 LYS   A N   1 
ATOM   2830 C CA  . LYS   A 1 393 ? -12.07972 5.61953   -11.27561 1.000 12.12441 ? 372 LYS   A CA  1 
ATOM   2831 C C   . LYS   A 1 393 ? -10.81461 5.41840   -12.09291 1.000 14.23360 ? 372 LYS   A C   1 
ATOM   2832 O O   . LYS   A 1 393 ? -9.74022  5.88979   -11.70623 1.000 16.81762 ? 372 LYS   A O   1 
ATOM   2833 C CB  . LYS   A 1 393 ? -12.51390 7.08902   -11.33401 1.000 12.25077 ? 372 LYS   A CB  1 
ATOM   2834 C CG  . LYS   A 1 393 ? -12.84424 7.56523   -12.74138 1.000 21.32188 ? 372 LYS   A CG  1 
ATOM   2835 C CD  . LYS   A 1 393 ? -13.54834 8.91183   -12.73217 1.000 26.24343 ? 372 LYS   A CD  1 
ATOM   2836 C CE  . LYS   A 1 393 ? -13.58415 9.52654   -14.12165 1.000 37.03304 ? 372 LYS   A CE  1 
ATOM   2837 N NZ  . LYS   A 1 393 ? -14.97532 9.64928   -14.63549 1.000 28.25079 ? 372 LYS   A NZ  1 
ATOM   2838 N N   . TRP   A 1 394 ? -10.94692 4.72323   -13.21855 1.000 10.80120 ? 373 TRP   A N   1 
ATOM   2839 C CA  . TRP   A 1 394 ? -9.83669  4.55517   -14.14680 1.000 11.69509 ? 373 TRP   A CA  1 
ATOM   2840 C C   . TRP   A 1 394 ? -9.82498  5.69212   -15.16370 1.000 16.41920 ? 373 TRP   A C   1 
ATOM   2841 O O   . TRP   A 1 394 ? -9.07109  5.65623   -16.13506 1.000 21.65505 ? 373 TRP   A O   1 
ATOM   2842 C CB  . TRP   A 1 394 ? -9.92018  3.20725   -14.86662 1.000 13.31102 ? 373 TRP   A CB  1 
ATOM   2843 C CG  . TRP   A 1 394 ? -9.42836  2.04489   -14.05646 1.000 17.41256 ? 373 TRP   A CG  1 
ATOM   2844 C CD1 . TRP   A 1 394 ? -8.23344  1.39861   -14.19157 1.000 20.79563 ? 373 TRP   A CD1 1 
ATOM   2845 C CD2 . TRP   A 1 394 ? -10.12425 1.38247   -12.99483 1.000 16.22091 ? 373 TRP   A CD2 1 
ATOM   2846 N NE1 . TRP   A 1 394 ? -8.14060  0.37849   -13.27569 1.000 24.10076 ? 373 TRP   A NE1 1 
ATOM   2847 C CE2 . TRP   A 1 394 ? -9.28940  0.34670   -12.53009 1.000 16.52682 ? 373 TRP   A CE2 1 
ATOM   2848 C CE3 . TRP   A 1 394 ? -11.37357 1.56285   -12.39402 1.000 11.38964 ? 373 TRP   A CE3 1 
ATOM   2849 C CZ2 . TRP   A 1 394 ? -9.66084  -0.50203  -11.48826 1.000 16.54893 ? 373 TRP   A CZ2 1 
ATOM   2850 C CZ3 . TRP   A 1 394 ? -11.74257 0.71700   -11.36260 1.000 12.77601 ? 373 TRP   A CZ3 1 
ATOM   2851 C CH2 . TRP   A 1 394 ? -10.88879 -0.30130  -10.91923 1.000 19.74970 ? 373 TRP   A CH2 1 
ATOM   2852 N N   . MET   B 1 22  ? -2.35521  24.22495  9.53443   1.000 32.62678 ? 1   MET   B N   1 
ATOM   2853 C CA  . MET   B 1 22  ? -1.95169  23.58400  10.77954  1.000 25.35005 ? 1   MET   B CA  1 
ATOM   2854 C C   . MET   B 1 22  ? -3.17999  23.14091  11.57156  1.000 28.13911 ? 1   MET   B C   1 
ATOM   2855 O O   . MET   B 1 22  ? -4.31229  23.45647  11.20697  1.000 28.80130 ? 1   MET   B O   1 
ATOM   2856 C CB  . MET   B 1 22  ? -1.08803  24.52947  11.61710  1.000 29.96958 ? 1   MET   B CB  1 
ATOM   2857 C CG  . MET   B 1 22  ? 0.27108   24.85705  11.00403  1.000 42.90657 ? 1   MET   B CG  1 
ATOM   2858 S SD  . MET   B 1 22  ? 0.87633   23.62042  9.83303   1.000 70.77961 ? 1   MET   B SD  1 
ATOM   2859 C CE  . MET   B 1 22  ? 2.48171   24.29997  9.40887   1.000 39.57034 ? 1   MET   B CE  1 
ATOM   2860 N N   . THR   B 1 23  ? -2.94645  22.40735  12.65476  1.000 20.77096 ? 2   THR   B N   1 
ATOM   2861 C CA  . THR   B 1 23  ? -4.00310  21.85307  13.48826  1.000 19.79949 ? 2   THR   B CA  1 
ATOM   2862 C C   . THR   B 1 23  ? -4.01438  22.54938  14.84248  1.000 11.71773 ? 2   THR   B C   1 
ATOM   2863 O O   . THR   B 1 23  ? -2.95766  22.86725  15.39255  1.000 13.86370 ? 2   THR   B O   1 
ATOM   2864 C CB  . THR   B 1 23  ? -3.80703  20.34422  13.67724  1.000 18.67921 ? 2   THR   B CB  1 
ATOM   2865 O OG1 . THR   B 1 23  ? -3.73835  19.70655  12.39624  1.000 25.67546 ? 2   THR   B OG1 1 
ATOM   2866 C CG2 . THR   B 1 23  ? -4.94381  19.74375  14.48352  1.000 21.96765 ? 2   THR   B CG2 1 
ATOM   2867 N N   . TYR   B 1 24  ? -5.21019  22.78444  15.37671  1.000 16.28709 ? 3   TYR   B N   1 
ATOM   2868 C CA  . TYR   B 1 24  ? -5.38563  23.42760  16.67272  1.000 14.85514 ? 3   TYR   B CA  1 
ATOM   2869 C C   . TYR   B 1 24  ? -5.83757  22.40656  17.70617  1.000 14.13581 ? 3   TYR   B C   1 
ATOM   2870 O O   . TYR   B 1 24  ? -6.81438  21.68447  17.48458  1.000 13.52901 ? 3   TYR   B O   1 
ATOM   2871 C CB  . TYR   B 1 24  ? -6.41207  24.55900  16.59258  1.000 14.77122 ? 3   TYR   B CB  1 
ATOM   2872 C CG  . TYR   B 1 24  ? -5.91350  25.80959  15.91018  1.000 21.23207 ? 3   TYR   B CG  1 
ATOM   2873 C CD1 . TYR   B 1 24  ? -5.71456  25.84436  14.53507  1.000 17.85271 ? 3   TYR   B CD1 1 
ATOM   2874 C CD2 . TYR   B 1 24  ? -5.64716  26.95931  16.64142  1.000 24.10530 ? 3   TYR   B CD2 1 
ATOM   2875 C CE1 . TYR   B 1 24  ? -5.26255  26.99035  13.90928  1.000 24.12697 ? 3   TYR   B CE1 1 
ATOM   2876 C CE2 . TYR   B 1 24  ? -5.19574  28.10787  16.02525  1.000 28.79113 ? 3   TYR   B CE2 1 
ATOM   2877 C CZ  . TYR   B 1 24  ? -5.00436  28.11797  14.66073  1.000 26.12534 ? 3   TYR   B CZ  1 
ATOM   2878 O OH  . TYR   B 1 24  ? -4.55483  29.26269  14.04695  1.000 37.93056 ? 3   TYR   B OH  1 
ATOM   2879 N N   . ILE   B 1 25  ? -5.13756  22.35934  18.83461  1.000 10.75755 ? 4   ILE   B N   1 
ATOM   2880 C CA  . ILE   B 1 25  ? -5.56780  21.57143  19.98363  1.000 10.49266 ? 4   ILE   B CA  1 
ATOM   2881 C C   . ILE   B 1 25  ? -6.50572  22.45449  20.79824  1.000 10.62783 ? 4   ILE   B C   1 
ATOM   2882 O O   . ILE   B 1 25  ? -6.09097  23.48159  21.34093  1.000 13.17365 ? 4   ILE   B O   1 
ATOM   2883 C CB  . ILE   B 1 25  ? -4.37523  21.08951  20.81711  1.000 11.68393 ? 4   ILE   B CB  1 
ATOM   2884 C CG1 . ILE   B 1 25  ? -3.58656  20.03052  20.04451  1.000 14.74977 ? 4   ILE   B CG1 1 
ATOM   2885 C CG2 . ILE   B 1 25  ? -4.84414  20.53553  22.15266  1.000 11.79750 ? 4   ILE   B CG2 1 
ATOM   2886 C CD1 . ILE   B 1 25  ? -2.24086  19.70572  20.65146  1.000 12.05566 ? 4   ILE   B CD1 1 
ATOM   2887 N N   . VAL   B 1 26  ? -7.77340  22.05980  20.87882  1.000 9.55244  ? 5   VAL   B N   1 
ATOM   2888 C CA  . VAL   B 1 26  ? -8.80610  22.93606  21.42531  1.000 10.86528 ? 5   VAL   B CA  1 
ATOM   2889 C C   . VAL   B 1 26  ? -9.04051  22.67870  22.90633  1.000 14.17727 ? 5   VAL   B C   1 
ATOM   2890 O O   . VAL   B 1 26  ? -9.14915  23.62128  23.69341  1.000 12.18060 ? 5   VAL   B O   1 
ATOM   2891 C CB  . VAL   B 1 26  ? -10.10725 22.77368  20.61570  1.000 10.72524 ? 5   VAL   B CB  1 
ATOM   2892 C CG1 . VAL   B 1 26  ? -11.20136 23.67472  21.17237  1.000 13.85285 ? 5   VAL   B CG1 1 
ATOM   2893 C CG2 . VAL   B 1 26  ? -9.85181  23.07840  19.15695  1.000 9.42645  ? 5   VAL   B CG2 1 
ATOM   2894 N N   . SER   B 1 27  ? -9.13486  21.41666  23.31183  1.000 12.47022 ? 6   SER   B N   1 
ATOM   2895 C CA  . SER   B 1 27  ? -9.42734  21.10367  24.70208  1.000 7.40187  ? 6   SER   B CA  1 
ATOM   2896 C C   . SER   B 1 27  ? -9.03273  19.66196  24.98089  1.000 8.32389  ? 6   SER   B C   1 
ATOM   2897 O O   . SER   B 1 27  ? -8.73416  18.88625  24.06909  1.000 9.66898  ? 6   SER   B O   1 
ATOM   2898 C CB  . SER   B 1 27  ? -10.90290 21.33915  25.02396  1.000 11.41643 ? 6   SER   B CB  1 
ATOM   2899 O OG  . SER   B 1 27  ? -11.13280 21.27593  26.41512  1.000 12.19771 ? 6   SER   B OG  1 
ATOM   2900 N N   . THR   B 1 28  ? -9.03573  19.31754  26.26606  1.000 12.23424 ? 7   THR   B N   1 
ATOM   2901 C CA  . THR   B 1 28  ? -8.63021  18.00270  26.73799  1.000 9.85784  ? 7   THR   B CA  1 
ATOM   2902 C C   . THR   B 1 28  ? -9.54863  17.57366  27.87102  1.000 8.29284  ? 7   THR   B C   1 
ATOM   2903 O O   . THR   B 1 28  ? -10.28033 18.38002  28.45012  1.000 9.40185  ? 7   THR   B O   1 
ATOM   2904 C CB  . THR   B 1 28  ? -7.17796  17.99307  27.23113  1.000 9.78289  ? 7   THR   B CB  1 
ATOM   2905 O OG1 . THR   B 1 28  ? -6.98716  19.07352  28.15259  1.000 14.41495 ? 7   THR   B OG1 1 
ATOM   2906 C CG2 . THR   B 1 28  ? -6.20399  18.12875  26.07104  1.000 10.88495 ? 7   THR   B CG2 1 
ATOM   2907 N N   . SER   B 1 29  ? -9.49332  16.28396  28.18861  1.000 7.40079  ? 8   SER   B N   1 
ATOM   2908 C CA  . SER   B 1 29  ? -10.21310 15.73676  29.32841  1.000 7.91049  ? 8   SER   B CA  1 
ATOM   2909 C C   . SER   B 1 29  ? -9.51726  14.45672  29.75675  1.000 9.91835  ? 8   SER   B C   1 
ATOM   2910 O O   . SER   B 1 29  ? -8.78527  13.83753  28.98129  1.000 6.06901  ? 8   SER   B O   1 
ATOM   2911 C CB  . SER   B 1 29  ? -11.67750 15.44699  28.99463  1.000 10.11798 ? 8   SER   B CB  1 
ATOM   2912 O OG  . SER   B 1 29  ? -11.76519 14.33083  28.12428  1.000 10.29746 ? 8   SER   B OG  1 
ATOM   2913 N N   . THR   B 1 30  ? -9.76440  14.06183  31.00066  1.000 11.08015 ? 9   THR   B N   1 
ATOM   2914 C CA  . THR   B 1 30  ? -9.23239  12.82236  31.54162  1.000 7.92085  ? 9   THR   B CA  1 
ATOM   2915 C C   . THR   B 1 30  ? -10.33890 12.07905  32.27202  1.000 5.15412  ? 9   THR   B C   1 
ATOM   2916 O O   . THR   B 1 30  ? -11.35518 12.65914  32.66135  1.000 8.58413  ? 9   THR   B O   1 
ATOM   2917 C CB  . THR   B 1 30  ? -8.05960  13.06628  32.50114  1.000 8.40931  ? 9   THR   B CB  1 
ATOM   2918 O OG1 . THR   B 1 30  ? -8.52001  13.81815  33.62834  1.000 9.50373  ? 9   THR   B OG1 1 
ATOM   2919 C CG2 . THR   B 1 30  ? -6.94222  13.82970  31.80681  1.000 11.35836 ? 9   THR   B CG2 1 
ATOM   2920 N N   . ALA   B 1 31  ? -10.13094 10.77855  32.44977  1.000 6.84525  ? 10  ALA   B N   1 
ATOM   2921 C CA  . ALA   B 1 31  ? -11.05704 9.95693   33.21665  1.000 8.27830  ? 10  ALA   B CA  1 
ATOM   2922 C C   . ALA   B 1 31  ? -10.26148 8.88223   33.93556  1.000 10.73517 ? 10  ALA   B C   1 
ATOM   2923 O O   . ALA   B 1 31  ? -9.38573  8.25347   33.33414  1.000 8.86364  ? 10  ALA   B O   1 
ATOM   2924 C CB  . ALA   B 1 31  ? -12.12337 9.32610   32.31519  1.000 8.76471  ? 10  ALA   B CB  1 
ATOM   2925 N N   . PHE   B 1 32  ? -10.56599 8.67692   35.21309  1.000 6.55324  ? 11  PHE   B N   1 
ATOM   2926 C CA  . PHE   B 1 32  ? -9.87639  7.68389   36.01457  1.000 7.34198  ? 11  PHE   B CA  1 
ATOM   2927 C C   . PHE   B 1 32  ? -10.87969 6.80839   36.74593  1.000 10.69375 ? 11  PHE   B C   1 
ATOM   2928 O O   . PHE   B 1 32  ? -11.99683 7.24631   37.03602  1.000 10.06498 ? 11  PHE   B O   1 
ATOM   2929 C CB  . PHE   B 1 32  ? -8.93542  8.35169   37.02731  1.000 10.45080 ? 11  PHE   B CB  1 
ATOM   2930 C CG  . PHE   B 1 32  ? -7.75208  9.01539   36.39673  1.000 8.78556  ? 11  PHE   B CG  1 
ATOM   2931 C CD1 . PHE   B 1 32  ? -6.66001  8.26427   35.98930  1.000 8.57111  ? 11  PHE   B CD1 1 
ATOM   2932 C CD2 . PHE   B 1 32  ? -7.72782  10.38701  36.20406  1.000 6.39779  ? 11  PHE   B CD2 1 
ATOM   2933 C CE1 . PHE   B 1 32  ? -5.56260  8.86999   35.40258  1.000 8.44590  ? 11  PHE   B CE1 1 
ATOM   2934 C CE2 . PHE   B 1 32  ? -6.63440  10.99635  35.62212  1.000 5.69100  ? 11  PHE   B CE2 1 
ATOM   2935 C CZ  . PHE   B 1 32  ? -5.54986  10.23854  35.22187  1.000 7.75378  ? 11  PHE   B CZ  1 
ATOM   2936 N N   . PRO   B 1 33  ? -10.51163 5.55869   37.04581  1.000 8.37055  ? 12  PRO   B N   1 
ATOM   2937 C CA  . PRO   B 1 33  ? -11.42400 4.68693   37.79803  1.000 13.37956 ? 12  PRO   B CA  1 
ATOM   2938 C C   . PRO   B 1 33  ? -11.59655 5.15747   39.23348  1.000 8.56716  ? 12  PRO   B C   1 
ATOM   2939 O O   . PRO   B 1 33  ? -10.94705 6.11821   39.65900  1.000 10.35159 ? 12  PRO   B O   1 
ATOM   2940 C CB  . PRO   B 1 33  ? -10.74869 3.31174   37.73058  1.000 11.56518 ? 12  PRO   B CB  1 
ATOM   2941 C CG  . PRO   B 1 33  ? -9.33306  3.57395   37.39777  1.000 13.10225 ? 12  PRO   B CG  1 
ATOM   2942 C CD  . PRO   B 1 33  ? -9.26480  4.87546   36.65984  1.000 11.78053 ? 12  PRO   B CD  1 
ATOM   2943 N N   . GLU   B 1 34  ? -12.47020 4.48683   39.98775  1.000 12.05538 ? 13  GLU   B N   1 
ATOM   2944 C CA  . GLU   B 1 34  ? -12.82778 4.97893   41.31613  1.000 17.94014 ? 13  GLU   B CA  1 
ATOM   2945 C C   . GLU   B 1 34  ? -11.71541 4.74722   42.33265  1.000 12.50436 ? 13  GLU   B C   1 
ATOM   2946 O O   . GLU   B 1 34  ? -11.51561 5.57031   43.23320  1.000 19.72684 ? 13  GLU   B O   1 
ATOM   2947 C CB  . GLU   B 1 34  ? -14.11956 4.31783   41.80034  1.000 21.91463 ? 13  GLU   B CB  1 
ATOM   2948 C CG  . GLU   B 1 34  ? -15.07250 3.88621   40.70214  1.000 31.23245 ? 13  GLU   B CG  1 
ATOM   2949 C CD  . GLU   B 1 34  ? -16.21263 3.03669   41.22854  1.000 38.71377 ? 13  GLU   B CD  1 
ATOM   2950 O OE1 . GLU   B 1 34  ? -15.98034 2.23440   42.15711  1.000 37.18574 ? 13  GLU   B OE1 1 
ATOM   2951 O OE2 . GLU   B 1 34  ? -17.34125 3.16989   40.71305  1.000 42.52630 ? 13  GLU   B OE2 1 
ATOM   2952 N N   . ASN   B 1 35  ? -10.98772 3.63754   42.21810  1.000 12.39757 ? 14  ASN   B N   1 
ATOM   2953 C CA  . ASN   B 1 35  ? -10.09392 3.18891   43.28401  1.000 13.01173 ? 14  ASN   B CA  1 
ATOM   2954 C C   . ASN   B 1 35  ? -8.68344  3.71628   43.04799  1.000 16.81345 ? 14  ASN   B C   1 
ATOM   2955 O O   . ASN   B 1 35  ? -7.99862  3.29186   42.11145  1.000 9.61641  ? 14  ASN   B O   1 
ATOM   2956 C CB  . ASN   B 1 35  ? -10.09496 1.66649   43.38434  1.000 10.07963 ? 14  ASN   B CB  1 
ATOM   2957 C CG  . ASN   B 1 35  ? -11.44998 1.11373   43.76086  1.000 17.54471 ? 14  ASN   B CG  1 
ATOM   2958 O OD1 . ASN   B 1 35  ? -12.26838 1.81117   44.35821  1.000 21.00650 ? 14  ASN   B OD1 1 
ATOM   2959 N ND2 . ASN   B 1 35  ? -11.69624 -0.14342  43.41443  1.000 15.15621 ? 14  ASN   B ND2 1 
ATOM   2960 N N   . TYR   B 1 36  ? -8.24819  4.62810   43.91278  1.000 11.21982 ? 15  TYR   B N   1 
ATOM   2961 C CA  . TYR   B 1 36  ? -6.88471  5.13964   43.91880  1.000 12.02602 ? 15  TYR   B CA  1 
ATOM   2962 C C   . TYR   B 1 36  ? -6.13810  4.50078   45.08390  1.000 15.06260 ? 15  TYR   B C   1 
ATOM   2963 O O   . TYR   B 1 36  ? -6.58302  4.59245   46.23399  1.000 13.54779 ? 15  TYR   B O   1 
ATOM   2964 C CB  . TYR   B 1 36  ? -6.88452  6.66297   44.04036  1.000 13.46531 ? 15  TYR   B CB  1 
ATOM   2965 C CG  . TYR   B 1 36  ? -5.52242  7.30129   43.92909  1.000 12.63210 ? 15  TYR   B CG  1 
ATOM   2966 C CD1 . TYR   B 1 36  ? -4.93376  7.52024   42.69079  1.000 15.32369 ? 15  TYR   B CD1 1 
ATOM   2967 C CD2 . TYR   B 1 36  ? -4.82680  7.69430   45.06506  1.000 15.61718 ? 15  TYR   B CD2 1 
ATOM   2968 C CE1 . TYR   B 1 36  ? -3.68921  8.11108   42.58759  1.000 11.02970 ? 15  TYR   B CE1 1 
ATOM   2969 C CE2 . TYR   B 1 36  ? -3.58412  8.28402   44.97355  1.000 13.50729 ? 15  TYR   B CE2 1 
ATOM   2970 C CZ  . TYR   B 1 36  ? -3.01887  8.49246   43.73402  1.000 13.85822 ? 15  TYR   B CZ  1 
ATOM   2971 O OH  . TYR   B 1 36  ? -1.77906  9.08328   43.64242  1.000 12.89250 ? 15  TYR   B OH  1 
ATOM   2972 N N   . TYR   B 1 37  ? -5.01634  3.84526   44.78703  1.000 10.45724 ? 16  TYR   B N   1 
ATOM   2973 C CA  . TYR   B 1 37  ? -4.24793  3.16075   45.81608  1.000 10.07448 ? 16  TYR   B CA  1 
ATOM   2974 C C   . TYR   B 1 37  ? -2.92986  3.87319   46.05396  1.000 9.06505  ? 16  TYR   B C   1 
ATOM   2975 O O   . TYR   B 1 37  ? -2.20936  4.15769   45.08965  1.000 9.69345  ? 16  TYR   B O   1 
ATOM   2976 C CB  . TYR   B 1 37  ? -3.97311  1.70736   45.41864  1.000 10.91575 ? 16  TYR   B CB  1 
ATOM   2977 C CG  . TYR   B 1 37  ? -5.20026  0.83473   45.34143  1.000 14.68544 ? 16  TYR   B CG  1 
ATOM   2978 C CD1 . TYR   B 1 37  ? -5.71196  0.22088   46.47553  1.000 19.79205 ? 16  TYR   B CD1 1 
ATOM   2979 C CD2 . TYR   B 1 37  ? -5.83798  0.61009   44.12900  1.000 15.10669 ? 16  TYR   B CD2 1 
ATOM   2980 C CE1 . TYR   B 1 37  ? -6.83362  -0.58413  46.40645  1.000 22.47919 ? 16  TYR   B CE1 1 
ATOM   2981 C CE2 . TYR   B 1 37  ? -6.95759  -0.19139  44.05058  1.000 15.64741 ? 16  TYR   B CE2 1 
ATOM   2982 C CZ  . TYR   B 1 37  ? -7.45145  -0.78546  45.19105  1.000 24.47713 ? 16  TYR   B CZ  1 
ATOM   2983 O OH  . TYR   B 1 37  ? -8.56686  -1.58424  45.11154  1.000 22.85749 ? 16  TYR   B OH  1 
ATOM   2984 N N   . PRO   B 1 38  ? -2.57511  4.16727   47.30355  1.000 14.01619 ? 17  PRO   B N   1 
ATOM   2985 C CA  . PRO   B 1 38  ? -1.22607  4.66793   47.58154  1.000 8.46696  ? 17  PRO   B CA  1 
ATOM   2986 C C   . PRO   B 1 38  ? -0.18739  3.63636   47.17433  1.000 7.97147  ? 17  PRO   B C   1 
ATOM   2987 O O   . PRO   B 1 38  ? -0.42470  2.42749   47.24136  1.000 6.80780  ? 17  PRO   B O   1 
ATOM   2988 C CB  . PRO   B 1 38  ? -1.22964  4.88930   49.10048  1.000 10.03234 ? 17  PRO   B CB  1 
ATOM   2989 C CG  . PRO   B 1 38  ? -2.67678  4.93139   49.48635  1.000 16.66645 ? 17  PRO   B CG  1 
ATOM   2990 C CD  . PRO   B 1 38  ? -3.36847  4.00685   48.53198  1.000 10.51386 ? 17  PRO   B CD  1 
ATOM   2991 N N   . GLN   B 1 39  ? 0.97324   4.12975   46.73157  1.000 13.44309 ? 18  GLN   B N   1 
ATOM   2992 C CA  . GLN   B 1 39  ? 2.03826   3.22970   46.30208  1.000 9.11079  ? 18  GLN   B CA  1 
ATOM   2993 C C   . GLN   B 1 39  ? 2.49107   2.31723   47.43586  1.000 7.85864  ? 18  GLN   B C   1 
ATOM   2994 O O   . GLN   B 1 39  ? 2.87835   1.16932   47.19011  1.000 6.79273  ? 18  GLN   B O   1 
ATOM   2995 C CB  . GLN   B 1 39  ? 3.21598   4.03729   45.75562  1.000 7.26372  ? 18  GLN   B CB  1 
ATOM   2996 C CG  . GLN   B 1 39  ? 4.37176   3.20168   45.19259  1.000 7.29448  ? 18  GLN   B CG  1 
ATOM   2997 C CD  . GLN   B 1 39  ? 4.13244   2.71519   43.76992  1.000 8.57914  ? 18  GLN   B CD  1 
ATOM   2998 O OE1 . GLN   B 1 39  ? 2.99510   2.61731   43.31727  1.000 8.36421  ? 18  GLN   B OE1 1 
ATOM   2999 N NE2 . GLN   B 1 39  ? 5.21376   2.41993   43.05502  1.000 8.04088  ? 18  GLN   B NE2 1 
ATOM   3000 N N   . THR   B 1 40  ? 2.43471   2.80039   48.68143  1.000 9.96227  ? 19  THR   B N   1 
ATOM   3001 C CA  . THR   B 1 40  ? 2.77721   1.95415   49.82169  1.000 9.57058  ? 19  THR   B CA  1 
ATOM   3002 C C   . THR   B 1 40  ? 1.82503   0.77085   49.94118  1.000 7.24975  ? 19  THR   B C   1 
ATOM   3003 O O   . THR   B 1 40  ? 2.23958   -0.33301  50.31180  1.000 8.15562  ? 19  THR   B O   1 
ATOM   3004 C CB  . THR   B 1 40  ? 2.76271   2.77119   51.11339  1.000 12.11194 ? 19  THR   B CB  1 
ATOM   3005 O OG1 . THR   B 1 40  ? 1.44834   3.29899   51.32425  1.000 11.67061 ? 19  THR   B OG1 1 
ATOM   3006 C CG2 . THR   B 1 40  ? 3.77318   3.90684   51.05394  1.000 13.21939 ? 19  THR   B CG2 1 
ATOM   3007 N N   . VAL   B 1 41  ? 0.53925   0.98778   49.65727  1.000 7.80002  ? 20  VAL   B N   1 
ATOM   3008 C CA  . VAL   B 1 41  ? -0.42949  -0.10214  49.71986  1.000 4.54044  ? 20  VAL   B CA  1 
ATOM   3009 C C   . VAL   B 1 41  ? -0.15118  -1.12467  48.62324  1.000 9.04967  ? 20  VAL   B C   1 
ATOM   3010 O O   . VAL   B 1 41  ? -0.19834  -2.33954  48.85774  1.000 8.33520  ? 20  VAL   B O   1 
ATOM   3011 C CB  . VAL   B 1 41  ? -1.86052  0.46104   49.63420  1.000 6.04657  ? 20  VAL   B CB  1 
ATOM   3012 C CG1 . VAL   B 1 41  ? -2.87435  -0.65886  49.46390  1.000 8.91482  ? 20  VAL   B CG1 1 
ATOM   3013 C CG2 . VAL   B 1 41  ? -2.17852  1.29719   50.87213  1.000 13.13320 ? 20  VAL   B CG2 1 
ATOM   3014 N N   . LEU   B 1 42  ? 0.15170   -0.65134  47.41197  1.000 4.97757  ? 21  LEU   B N   1 
ATOM   3015 C CA  . LEU   B 1 42  ? 0.43015   -1.56283  46.30626  1.000 8.89436  ? 21  LEU   B CA  1 
ATOM   3016 C C   . LEU   B 1 42  ? 1.69421   -2.37689  46.55867  1.000 7.37313  ? 21  LEU   B C   1 
ATOM   3017 O O   . LEU   B 1 42  ? 1.73875   -3.57286  46.24544  1.000 10.15853 ? 21  LEU   B O   1 
ATOM   3018 C CB  . LEU   B 1 42  ? 0.53879   -0.77868  44.99804  1.000 7.14537  ? 21  LEU   B CB  1 
ATOM   3019 C CG  . LEU   B 1 42  ? -0.73198  -0.03741  44.57868  1.000 7.48127  ? 21  LEU   B CG  1 
ATOM   3020 C CD1 . LEU   B 1 42  ? -0.48152  0.83713   43.35445  1.000 7.41773  ? 21  LEU   B CD1 1 
ATOM   3021 C CD2 . LEU   B 1 42  ? -1.84803  -1.03027  44.30056  1.000 14.75032 ? 21  LEU   B CD2 1 
ATOM   3022 N N   . ALA   B 1 43  ? 2.73453   -1.74857  47.11452  1.000 7.28648  ? 22  ALA   B N   1 
ATOM   3023 C CA  . ALA   B 1 43  ? 3.93825   -2.49816  47.46273  1.000 8.18098  ? 22  ALA   B CA  1 
ATOM   3024 C C   . ALA   B 1 43  ? 3.63549   -3.56774  48.50367  1.000 7.89184  ? 22  ALA   B C   1 
ATOM   3025 O O   . ALA   B 1 43  ? 4.07992   -4.71450  48.37530  1.000 11.81592 ? 22  ALA   B O   1 
ATOM   3026 C CB  . ALA   B 1 43  ? 5.02433   -1.54793  47.96868  1.000 10.83726 ? 22  ALA   B CB  1 
ATOM   3027 N N   . ALA   B 1 44  ? 2.86683   -3.21404  49.53750  1.000 11.30651 ? 23  ALA   B N   1 
ATOM   3028 C CA  . ALA   B 1 44  ? 2.49752   -4.19431  50.55197  1.000 12.38050 ? 23  ALA   B CA  1 
ATOM   3029 C C   . ALA   B 1 44  ? 1.65915   -5.32048  49.96399  1.000 14.04779 ? 23  ALA   B C   1 
ATOM   3030 O O   . ALA   B 1 44  ? 1.76524   -6.46876  50.40944  1.000 11.90551 ? 23  ALA   B O   1 
ATOM   3031 C CB  . ALA   B 1 44  ? 1.74370   -3.51374  51.69425  1.000 12.08923 ? 23  ALA   B CB  1 
ATOM   3032 N N   . ALA   B 1 45  ? 0.81576   -5.01387  48.97430  1.000 11.32567 ? 24  ALA   B N   1 
ATOM   3033 C CA  . ALA   B 1 45  ? 0.03470   -6.06084  48.32432  1.000 10.34522 ? 24  ALA   B CA  1 
ATOM   3034 C C   . ALA   B 1 45  ? 0.93933   -7.06678  47.62325  1.000 15.72142 ? 24  ALA   B C   1 
ATOM   3035 O O   . ALA   B 1 45  ? 0.72399   -8.28131  47.72098  1.000 13.52562 ? 24  ALA   B O   1 
ATOM   3036 C CB  . ALA   B 1 45  ? -0.95142  -5.44343  47.33345  1.000 15.91219 ? 24  ALA   B CB  1 
ATOM   3037 N N   . LEU   B 1 46  ? 1.96090   -6.58183  46.91268  1.000 11.96579 ? 25  LEU   B N   1 
ATOM   3038 C CA  . LEU   B 1 46  ? 2.89144   -7.49401  46.25584  1.000 12.35200 ? 25  LEU   B CA  1 
ATOM   3039 C C   . LEU   B 1 46  ? 3.76797   -8.21289  47.27267  1.000 15.61882 ? 25  LEU   B C   1 
ATOM   3040 O O   . LEU   B 1 46  ? 4.06603   -9.40254  47.11051  1.000 13.30952 ? 25  LEU   B O   1 
ATOM   3041 C CB  . LEU   B 1 46  ? 3.75442   -6.73985  45.24548  1.000 15.50986 ? 25  LEU   B CB  1 
ATOM   3042 C CG  . LEU   B 1 46  ? 4.56605   -7.62862  44.29895  1.000 13.41869 ? 25  LEU   B CG  1 
ATOM   3043 C CD1 . LEU   B 1 46  ? 3.65192   -8.48879  43.43044  1.000 10.90595 ? 25  LEU   B CD1 1 
ATOM   3044 C CD2 . LEU   B 1 46  ? 5.51372   -6.79872  43.44639  1.000 17.76747 ? 25  LEU   B CD2 1 
ATOM   3045 N N   . ARG   B 1 47  ? 4.19561   -7.50750  48.32461  1.000 13.99468 ? 26  ARG   B N   1 
ATOM   3046 C CA  . ARG   B 1 47  ? 4.97512   -8.15893  49.37167  1.000 15.95747 ? 26  ARG   B CA  1 
ATOM   3047 C C   . ARG   B 1 47  ? 4.19313   -9.30352  49.99363  1.000 12.88046 ? 26  ARG   B C   1 
ATOM   3048 O O   . ARG   B 1 47  ? 4.73949   -10.39160 50.21322  1.000 15.82351 ? 26  ARG   B O   1 
ATOM   3049 C CB  . ARG   B 1 47  ? 5.37426   -7.15270  50.45067  1.000 14.29038 ? 26  ARG   B CB  1 
ATOM   3050 C CG  . ARG   B 1 47  ? 6.52810   -6.25158  50.08325  1.000 14.82184 ? 26  ARG   B CG  1 
ATOM   3051 C CD  . ARG   B 1 47  ? 7.19200   -5.69464  51.33046  1.000 16.43698 ? 26  ARG   B CD  1 
ATOM   3052 N NE  . ARG   B 1 47  ? 6.23298   -5.01956  52.19562  1.000 20.62057 ? 26  ARG   B NE  1 
ATOM   3053 C CZ  . ARG   B 1 47  ? 5.91298   -3.73556  52.10693  1.000 22.88456 ? 26  ARG   B CZ  1 
ATOM   3054 N NH1 . ARG   B 1 47  ? 6.45823   -2.94779  51.19407  1.000 18.80826 ? 26  ARG   B NH1 1 
ATOM   3055 N NH2 . ARG   B 1 47  ? 5.01796   -3.23067  52.95187  1.000 20.62617 ? 26  ARG   B NH2 1 
ATOM   3056 N N   . ARG   B 1 48  ? 2.90511   -9.08032  50.27254  1.000 14.61640 ? 27  ARG   B N   1 
ATOM   3057 C CA  . ARG   B 1 48  ? 2.08938   -10.13454 50.86235  1.000 13.61955 ? 27  ARG   B CA  1 
ATOM   3058 C C   . ARG   B 1 48  ? 1.98279   -11.32843 49.92528  1.000 21.06996 ? 27  ARG   B C   1 
ATOM   3059 O O   . ARG   B 1 48  ? 2.06016   -12.47973 50.36859  1.000 18.95081 ? 27  ARG   B O   1 
ATOM   3060 C CB  . ARG   B 1 48  ? 0.69903   -9.60662  51.21633  1.000 15.95768 ? 27  ARG   B CB  1 
ATOM   3061 C CG  . ARG   B 1 48  ? -0.19109  -10.66982 51.83379  1.000 19.77283 ? 27  ARG   B CG  1 
ATOM   3062 C CD  . ARG   B 1 48  ? -1.23664  -10.07885 52.76318  1.000 28.87639 ? 27  ARG   B CD  1 
ATOM   3063 N NE  . ARG   B 1 48  ? -2.42323  -9.62381  52.05187  1.000 36.64173 ? 27  ARG   B NE  1 
ATOM   3064 C CZ  . ARG   B 1 48  ? -3.60952  -10.21015 52.13869  1.000 37.23642 ? 27  ARG   B CZ  1 
ATOM   3065 N NH1 . ARG   B 1 48  ? -3.79851  -11.27789 52.89737  1.000 37.51179 ? 27  ARG   B NH1 1 
ATOM   3066 N NH2 . ARG   B 1 48  ? -4.63108  -9.71474  51.44600  1.000 39.26707 ? 27  ARG   B NH2 1 
ATOM   3067 N N   . PHE   B 1 49  ? 1.81962   -11.07518 48.62325  1.000 14.90039 ? 28  PHE   B N   1 
ATOM   3068 C CA  . PHE   B 1 49  ? 1.76663   -12.17252 47.66191  1.000 14.33770 ? 28  PHE   B CA  1 
ATOM   3069 C C   . PHE   B 1 49  ? 3.04200   -13.00319 47.71523  1.000 11.32830 ? 28  PHE   B C   1 
ATOM   3070 O O   . PHE   B 1 49  ? 2.98798   -14.23602 47.74536  1.000 18.78462 ? 28  PHE   B O   1 
ATOM   3071 C CB  . PHE   B 1 49  ? 1.53532   -11.63566 46.24836  1.000 14.33808 ? 28  PHE   B CB  1 
ATOM   3072 C CG  . PHE   B 1 49  ? 1.67492   -12.68306 45.17811  1.000 17.28984 ? 28  PHE   B CG  1 
ATOM   3073 C CD1 . PHE   B 1 49  ? 0.67617   -13.62194 44.97501  1.000 17.07244 ? 28  PHE   B CD1 1 
ATOM   3074 C CD2 . PHE   B 1 49  ? 2.81043   -12.73913 44.38690  1.000 17.77634 ? 28  PHE   B CD2 1 
ATOM   3075 C CE1 . PHE   B 1 49  ? 0.80399   -14.59119 43.99927  1.000 19.32411 ? 28  PHE   B CE1 1 
ATOM   3076 C CE2 . PHE   B 1 49  ? 2.94492   -13.70665 43.40804  1.000 17.03759 ? 28  PHE   B CE2 1 
ATOM   3077 C CZ  . PHE   B 1 49  ? 1.94189   -14.63454 43.21626  1.000 21.80260 ? 28  PHE   B CZ  1 
ATOM   3078 N N   . PHE   B 1 50  ? 4.20146   -12.33973 47.74192  1.000 14.78036 ? 29  PHE   B N   1 
ATOM   3079 C CA  . PHE   B 1 50  ? 5.46763   -13.04924 47.90470  1.000 16.12136 ? 29  PHE   B CA  1 
ATOM   3080 C C   . PHE   B 1 50  ? 5.47673   -13.86206 49.19262  1.000 19.75547 ? 29  PHE   B C   1 
ATOM   3081 O O   . PHE   B 1 50  ? 5.85601   -15.03919 49.19908  1.000 23.07322 ? 29  PHE   B O   1 
ATOM   3082 C CB  . PHE   B 1 50  ? 6.63434   -12.05943 47.91753  1.000 15.97648 ? 29  PHE   B CB  1 
ATOM   3083 C CG  . PHE   B 1 50  ? 7.13325   -11.66480 46.55666  1.000 18.26633 ? 29  PHE   B CG  1 
ATOM   3084 C CD1 . PHE   B 1 50  ? 6.25918   -11.26259 45.56355  1.000 16.08372 ? 29  PHE   B CD1 1 
ATOM   3085 C CD2 . PHE   B 1 50  ? 8.49171   -11.66872 46.28585  1.000 17.12023 ? 29  PHE   B CD2 1 
ATOM   3086 C CE1 . PHE   B 1 50  ? 6.73017   -10.88756 44.31837  1.000 14.85836 ? 29  PHE   B CE1 1 
ATOM   3087 C CE2 . PHE   B 1 50  ? 8.96787   -11.29623 45.04406  1.000 18.16969 ? 29  PHE   B CE2 1 
ATOM   3088 C CZ  . PHE   B 1 50  ? 8.08497   -10.90324 44.06000  1.000 10.12272 ? 29  PHE   B CZ  1 
ATOM   3089 N N   . THR   B 1 51  ? 5.06458   -13.24057 50.29848  1.000 15.02943 ? 30  THR   B N   1 
ATOM   3090 C CA  . THR   B 1 51  ? 5.17991   -13.88450 51.60235  1.000 18.14784 ? 30  THR   B CA  1 
ATOM   3091 C C   . THR   B 1 51  ? 4.23097   -15.06995 51.72619  1.000 12.41192 ? 30  THR   B C   1 
ATOM   3092 O O   . THR   B 1 51  ? 4.64424   -16.16356 52.12807  1.000 22.96340 ? 30  THR   B O   1 
ATOM   3093 C CB  . THR   B 1 51  ? 4.92861   -12.86433 52.71245  1.000 18.74812 ? 30  THR   B CB  1 
ATOM   3094 O OG1 . THR   B 1 51  ? 6.00186   -11.91442 52.72790  1.000 16.38830 ? 30  THR   B OG1 1 
ATOM   3095 C CG2 . THR   B 1 51  ? 4.85635   -13.55428 54.06844  1.000 14.87958 ? 30  THR   B CG2 1 
ATOM   3096 N N   . VAL   B 1 52  ? 2.95634   -14.88242 51.37170  1.000 17.59073 ? 31  VAL   B N   1 
ATOM   3097 C CA  . VAL   B 1 52  ? 2.00625   -15.98548 51.45871  1.000 18.61500 ? 31  VAL   B CA  1 
ATOM   3098 C C   . VAL   B 1 52  ? 2.39555   -17.12189 50.53088  1.000 24.91244 ? 31  VAL   B C   1 
ATOM   3099 O O   . VAL   B 1 52  ? 1.99052   -18.26885 50.74992  1.000 23.26916 ? 31  VAL   B O   1 
ATOM   3100 C CB  . VAL   B 1 52  ? 0.56515   -15.51274 51.15904  1.000 21.85144 ? 31  VAL   B CB  1 
ATOM   3101 C CG1 . VAL   B 1 52  ? 0.19755   -14.32122 52.02835  1.000 23.63363 ? 31  VAL   B CG1 1 
ATOM   3102 C CG2 . VAL   B 1 52  ? 0.39072   -15.18968 49.68021  1.000 20.62665 ? 31  VAL   B CG2 1 
ATOM   3103 N N   . MET   B 1 53  ? 3.18170   -16.83609 49.49690  1.000 20.19497 ? 32  MET   B N   1 
ATOM   3104 C CA  . MET   B 1 53  ? 3.53574   -17.84052 48.50968  1.000 20.23191 ? 32  MET   B CA  1 
ATOM   3105 C C   . MET   B 1 53  ? 4.87514   -18.48932 48.82562  1.000 24.21539 ? 32  MET   B C   1 
ATOM   3106 O O   . MET   B 1 53  ? 5.28740   -19.41768 48.12192  1.000 28.09428 ? 32  MET   B O   1 
ATOM   3107 C CB  . MET   B 1 53  ? 3.57786   -17.21367 47.12202  1.000 25.50574 ? 32  MET   B CB  1 
ATOM   3108 C CG  . MET   B 1 53  ? 2.19184   -17.06981 46.52638  1.000 20.91173 ? 32  MET   B CG  1 
ATOM   3109 S SD  . MET   B 1 53  ? 1.39007   -18.44433 45.70700  1.000 26.28344 ? 32  MET   B SD  1 
ATOM   3110 C CE  . MET   B 1 53  ? -0.25872  -17.74608 45.72765  1.000 39.09993 ? 32  MET   B CE  1 
ATOM   3111 N N   . GLU   B 1 54  ? 5.55708   -18.01199 49.87140  1.000 21.86166 ? 33  GLU   B N   1 
ATOM   3112 C CA  . GLU   B 1 54  ? 6.85838   -18.52385 50.30145  1.000 24.95502 ? 33  GLU   B CA  1 
ATOM   3113 C C   . GLU   B 1 54  ? 7.88346   -18.47351 49.16983  1.000 28.42963 ? 33  GLU   B C   1 
ATOM   3114 O O   . GLU   B 1 54  ? 8.63787   -19.41904 48.93916  1.000 22.25275 ? 33  GLU   B O   1 
ATOM   3115 C CB  . GLU   B 1 54  ? 6.71891   -19.93424 50.87550  1.000 22.32820 ? 33  GLU   B CB  1 
ATOM   3116 C CG  . GLU   B 1 54  ? 5.52539   -20.08130 51.80152  1.000 23.16910 ? 33  GLU   B CG  1 
ATOM   3117 C CD  . GLU   B 1 54  ? 5.49949   -21.40695 52.52288  1.000 31.73933 ? 33  GLU   B CD  1 
ATOM   3118 O OE1 . GLU   B 1 54  ? 6.55662   -22.06976 52.59809  1.000 27.88513 ? 33  GLU   B OE1 1 
ATOM   3119 O OE2 . GLU   B 1 54  ? 4.41873   -21.78189 53.02293  1.000 31.30265 ? 33  GLU   B OE2 1 
ATOM   3120 N N   . LEU   B 1 55  ? 7.91679   -17.34253 48.46880  1.000 23.10406 ? 34  LEU   B N   1 
ATOM   3121 C CA  . LEU   B 1 55  ? 8.85806   -17.14140 47.37439  1.000 20.29932 ? 34  LEU   B CA  1 
ATOM   3122 C C   . LEU   B 1 55  ? 10.18216  -16.63208 47.93420  1.000 25.02482 ? 34  LEU   B C   1 
ATOM   3123 O O   . LEU   B 1 55  ? 10.21774  -15.61367 48.63352  1.000 26.92127 ? 34  LEU   B O   1 
ATOM   3124 C CB  . LEU   B 1 55  ? 8.29063   -16.16687 46.34393  1.000 22.59376 ? 34  LEU   B CB  1 
ATOM   3125 C CG  . LEU   B 1 55  ? 6.94062   -16.57311 45.74926  1.000 21.53887 ? 34  LEU   B CG  1 
ATOM   3126 C CD1 . LEU   B 1 55  ? 6.46123   -15.54681 44.72979  1.000 23.41658 ? 34  LEU   B CD1 1 
ATOM   3127 C CD2 . LEU   B 1 55  ? 7.01580   -17.96467 45.13522  1.000 24.89695 ? 34  LEU   B CD2 1 
ATOM   3128 N N   . ASP   B 1 56  ? 11.26893  -17.33700 47.61738  1.000 18.30534 ? 35  ASP   B N   1 
ATOM   3129 C CA  . ASP   B 1 56  ? 12.58587  -17.04278 48.18067  1.000 24.79966 ? 35  ASP   B CA  1 
ATOM   3130 C C   . ASP   B 1 56  ? 13.20471  -15.89000 47.39398  1.000 20.31337 ? 35  ASP   B C   1 
ATOM   3131 O O   . ASP   B 1 56  ? 14.03886  -16.06800 46.50291  1.000 21.93124 ? 35  ASP   B O   1 
ATOM   3132 C CB  . ASP   B 1 56  ? 13.46317  -18.28937 48.15758  1.000 26.25471 ? 35  ASP   B CB  1 
ATOM   3133 C CG  . ASP   B 1 56  ? 14.79881  -18.08461 48.85015  1.000 31.54317 ? 35  ASP   B CG  1 
ATOM   3134 O OD1 . ASP   B 1 56  ? 14.99288  -17.02930 49.48870  1.000 31.20518 ? 35  ASP   B OD1 1 
ATOM   3135 O OD2 . ASP   B 1 56  ? 15.65541  -18.98927 48.76059  1.000 37.47969 ? 35  ASP   B OD2 1 
ATOM   3136 N N   . PHE   B 1 57  ? 12.78098  -14.67729 47.74209  1.000 20.72432 ? 36  PHE   B N   1 
ATOM   3137 C CA  . PHE   B 1 57  ? 13.30591  -13.47193 47.12163  1.000 22.91233 ? 36  PHE   B CA  1 
ATOM   3138 C C   . PHE   B 1 57  ? 13.29002  -12.34739 48.14592  1.000 22.25648 ? 36  PHE   B C   1 
ATOM   3139 O O   . PHE   B 1 57  ? 12.39455  -12.27244 48.99180  1.000 24.13718 ? 36  PHE   B O   1 
ATOM   3140 C CB  . PHE   B 1 57  ? 12.50082  -13.08277 45.87435  1.000 19.98305 ? 36  PHE   B CB  1 
ATOM   3141 C CG  . PHE   B 1 57  ? 13.26883  -12.23783 44.90213  1.000 16.67230 ? 36  PHE   B CG  1 
ATOM   3142 C CD1 . PHE   B 1 57  ? 14.16670  -12.81821 44.02069  1.000 24.11175 ? 36  PHE   B CD1 1 
ATOM   3143 C CD2 . PHE   B 1 57  ? 13.09590  -10.86506 44.86818  1.000 16.90198 ? 36  PHE   B CD2 1 
ATOM   3144 C CE1 . PHE   B 1 57  ? 14.87816  -12.04421 43.12773  1.000 22.64979 ? 36  PHE   B CE1 1 
ATOM   3145 C CE2 . PHE   B 1 57  ? 13.80327  -10.08587 43.97579  1.000 16.61471 ? 36  PHE   B CE2 1 
ATOM   3146 C CZ  . PHE   B 1 57  ? 14.69491  -10.67544 43.10449  1.000 21.43798 ? 36  PHE   B CZ  1 
ATOM   3147 N N   . ASP   B 1 58  ? 14.29162  -11.47480 48.06295  1.000 17.22097 ? 37  ASP   B N   1 
ATOM   3148 C CA  . ASP   B 1 58  ? 14.43111  -10.37937 49.01804  1.000 22.94566 ? 37  ASP   B CA  1 
ATOM   3149 C C   . ASP   B 1 58  ? 13.27646  -9.40109  48.83570  1.000 24.13354 ? 37  ASP   B C   1 
ATOM   3150 O O   . ASP   B 1 58  ? 13.15395  -8.75832  47.78770  1.000 14.79985 ? 37  ASP   B O   1 
ATOM   3151 C CB  . ASP   B 1 58  ? 15.77480  -9.68161  48.82712  1.000 21.49761 ? 37  ASP   B CB  1 
ATOM   3152 C CG  . ASP   B 1 58  ? 15.96093  -8.49091  49.75903  1.000 28.76154 ? 37  ASP   B CG  1 
ATOM   3153 O OD1 . ASP   B 1 58  ? 15.20487  -8.36456  50.74666  1.000 23.59998 ? 37  ASP   B OD1 1 
ATOM   3154 O OD2 . ASP   B 1 58  ? 16.86623  -7.67070  49.49584  1.000 35.86626 ? 37  ASP   B OD2 1 
ATOM   3155 N N   . LEU   B 1 59  ? 12.43388  -9.28187  49.86473  1.000 24.19093 ? 38  LEU   B N   1 
ATOM   3156 C CA  . LEU   B 1 59  ? 11.30697  -8.35804  49.81938  1.000 17.81883 ? 38  LEU   B CA  1 
ATOM   3157 C C   . LEU   B 1 59  ? 11.75115  -6.90879  49.69822  1.000 19.91355 ? 38  LEU   B C   1 
ATOM   3158 O O   . LEU   B 1 59  ? 10.96626  -6.06894  49.24636  1.000 24.49496 ? 38  LEU   B O   1 
ATOM   3159 C CB  . LEU   B 1 59  ? 10.44065  -8.52428  51.06913  1.000 23.09055 ? 38  LEU   B CB  1 
ATOM   3160 C CG  . LEU   B 1 59  ? 9.62282   -9.81207  51.15698  1.000 29.19290 ? 38  LEU   B CG  1 
ATOM   3161 C CD1 . LEU   B 1 59  ? 8.75328   -9.81864  52.40507  1.000 19.85297 ? 38  LEU   B CD1 1 
ATOM   3162 C CD2 . LEU   B 1 59  ? 8.77704   -9.97218  49.90665  1.000 16.80040 ? 38  LEU   B CD2 1 
ATOM   3163 N N   . GLU   B 1 60  ? 12.98496  -6.59301  50.09804  1.000 17.89307 ? 39  GLU   B N   1 
ATOM   3164 C CA  . GLU   B 1 60  ? 13.45470  -5.21602  50.02744  1.000 23.85720 ? 39  GLU   B CA  1 
ATOM   3165 C C   . GLU   B 1 60  ? 13.58250  -4.72472  48.59073  1.000 21.40643 ? 39  GLU   B C   1 
ATOM   3166 O O   . GLU   B 1 60  ? 13.56833  -3.51084  48.35970  1.000 17.60430 ? 39  GLU   B O   1 
ATOM   3167 C CB  . GLU   B 1 60  ? 14.79354  -5.07748  50.75700  1.000 23.51859 ? 39  GLU   B CB  1 
ATOM   3168 C CG  . GLU   B 1 60  ? 14.68938  -4.55262  52.19561  1.000 41.04483 ? 39  GLU   B CG  1 
ATOM   3169 C CD  . GLU   B 1 60  ? 13.72914  -3.37957  52.36638  1.000 44.86604 ? 39  GLU   B CD  1 
ATOM   3170 O OE1 . GLU   B 1 60  ? 13.57465  -2.56665  51.42567  1.000 40.75149 ? 39  GLU   B OE1 1 
ATOM   3171 O OE2 . GLU   B 1 60  ? 13.11467  -3.27614  53.44841  1.000 43.72691 ? 39  GLU   B OE2 1 
ATOM   3172 N N   . GLN   B 1 61  ? 13.69870  -5.63485  47.62109  1.000 18.94711 ? 40  GLN   B N   1 
ATOM   3173 C CA  . GLN   B 1 61  ? 13.73234  -5.21152  46.22586  1.000 17.52204 ? 40  GLN   B CA  1 
ATOM   3174 C C   . GLN   B 1 61  ? 12.36726  -4.72889  45.75228  1.000 16.95019 ? 40  GLN   B C   1 
ATOM   3175 O O   . GLN   B 1 61  ? 12.29194  -3.87060  44.86574  1.000 18.60575 ? 40  GLN   B O   1 
ATOM   3176 C CB  . GLN   B 1 61  ? 14.24491  -6.34755  45.34203  1.000 23.75061 ? 40  GLN   B CB  1 
ATOM   3177 C CG  . GLN   B 1 61  ? 15.63554  -6.82751  45.72435  1.000 18.75004 ? 40  GLN   B CG  1 
ATOM   3178 C CD  . GLN   B 1 61  ? 16.67807  -5.73298  45.58885  1.000 29.82750 ? 40  GLN   B CD  1 
ATOM   3179 O OE1 . GLN   B 1 61  ? 16.73983  -5.04162  44.57342  1.000 27.51629 ? 40  GLN   B OE1 1 
ATOM   3180 N NE2 . GLN   B 1 61  ? 17.50147  -5.56831  46.61782  1.000 33.96294 ? 40  GLN   B NE2 1 
ATOM   3181 N N   . ILE   B 1 62  ? 11.28241  -5.26092  46.32056  1.000 12.57106 ? 41  ILE   B N   1 
ATOM   3182 C CA  . ILE   B 1 62  ? 9.95872   -4.72030  46.02050  1.000 15.70693 ? 41  ILE   B CA  1 
ATOM   3183 C C   . ILE   B 1 62  ? 9.85575   -3.28335  46.51364  1.000 18.05682 ? 41  ILE   B C   1 
ATOM   3184 O O   . ILE   B 1 62  ? 9.44799   -2.38084  45.77342  1.000 16.84601 ? 41  ILE   B O   1 
ATOM   3185 C CB  . ILE   B 1 62  ? 8.85688   -5.60457  46.63128  1.000 12.40795 ? 41  ILE   B CB  1 
ATOM   3186 C CG1 . ILE   B 1 62  ? 8.87683   -6.99972  46.00429  1.000 13.74932 ? 41  ILE   B CG1 1 
ATOM   3187 C CG2 . ILE   B 1 62  ? 7.49544   -4.94559  46.45889  1.000 9.50449  ? 41  ILE   B CG2 1 
ATOM   3188 C CD1 . ILE   B 1 62  ? 7.81850   -7.93726  46.55400  1.000 13.24633 ? 41  ILE   B CD1 1 
ATOM   3189 N N   . ASP   B 1 63  ? 10.23767  -3.04954  47.77233  1.000 17.80053 ? 42  ASP   B N   1 
ATOM   3190 C CA  . ASP   B 1 63  ? 10.22245  -1.69476  48.31678  1.000 17.71354 ? 42  ASP   B CA  1 
ATOM   3191 C C   . ASP   B 1 63  ? 11.16545  -0.78047  47.54927  1.000 13.70902 ? 42  ASP   B C   1 
ATOM   3192 O O   . ASP   B 1 63  ? 10.84026  0.38477   47.29501  1.000 17.97242 ? 42  ASP   B O   1 
ATOM   3193 C CB  . ASP   B 1 63  ? 10.59555  -1.71407  49.80015  1.000 16.26051 ? 42  ASP   B CB  1 
ATOM   3194 C CG  . ASP   B 1 63  ? 9.65644   -2.56383  50.62925  1.000 22.91124 ? 42  ASP   B CG  1 
ATOM   3195 O OD1 . ASP   B 1 63  ? 8.91085   -3.37548  50.04707  1.000 24.60700 ? 42  ASP   B OD1 1 
ATOM   3196 O OD2 . ASP   B 1 63  ? 9.67245   -2.42377  51.86967  1.000 33.53608 ? 42  ASP   B OD2 1 
ATOM   3197 N N   . ARG   B 1 64  ? 12.34312  -1.28986  47.18328  1.000 17.51043 ? 43  ARG   B N   1 
ATOM   3198 C CA  . ARG   B 1 64  ? 13.32018  -0.48172  46.46038  1.000 19.95740 ? 43  ARG   B CA  1 
ATOM   3199 C C   . ARG   B 1 64  ? 12.73729  0.06678   45.16297  1.000 14.18369 ? 43  ARG   B C   1 
ATOM   3200 O O   . ARG   B 1 64  ? 12.77748  1.27684   44.91257  1.000 11.39288 ? 43  ARG   B O   1 
ATOM   3201 C CB  . ARG   B 1 64  ? 14.57192  -1.31729  46.18185  1.000 15.89298 ? 43  ARG   B CB  1 
ATOM   3202 C CG  . ARG   B 1 64  ? 15.62239  -0.64114  45.31478  1.000 20.52853 ? 43  ARG   B CG  1 
ATOM   3203 C CD  . ARG   B 1 64  ? 16.73621  -1.62180  44.96961  1.000 26.62380 ? 43  ARG   B CD  1 
ATOM   3204 N NE  . ARG   B 1 64  ? 17.66747  -1.08308  43.98585  1.000 32.61504 ? 43  ARG   B NE  1 
ATOM   3205 C CZ  . ARG   B 1 64  ? 18.42530  -1.82251  43.18707  1.000 36.78046 ? 43  ARG   B CZ  1 
ATOM   3206 N NH1 . ARG   B 1 64  ? 18.39033  -3.14524  43.22882  1.000 33.42703 ? 43  ARG   B NH1 1 
ATOM   3207 N NH2 . ARG   B 1 64  ? 19.23918  -1.22009  42.32467  1.000 31.56358 ? 43  ARG   B NH2 1 
ATOM   3208 N N   . PHE   B 1 65  ? 12.17315  -0.80562  44.33022  1.000 16.97761 ? 44  PHE   B N   1 
ATOM   3209 C CA  . PHE   B 1 65  ? 11.71371  -0.34806  43.02582  1.000 16.02381 ? 44  PHE   B CA  1 
ATOM   3210 C C   . PHE   B 1 65  ? 10.35280  0.33205   43.10022  1.000 12.02476 ? 44  PHE   B C   1 
ATOM   3211 O O   . PHE   B 1 65  ? 10.07041  1.21841   42.28749  1.000 20.56232 ? 44  PHE   B O   1 
ATOM   3212 C CB  . PHE   B 1 65  ? 11.70828  -1.51401  42.03655  1.000 17.45273 ? 44  PHE   B CB  1 
ATOM   3213 C CG  . PHE   B 1 65  ? 13.08802  -1.92669  41.60248  1.000 11.94250 ? 44  PHE   B CG  1 
ATOM   3214 C CD1 . PHE   B 1 65  ? 13.86049  -1.08771  40.81575  1.000 18.03422 ? 44  PHE   B CD1 1 
ATOM   3215 C CD2 . PHE   B 1 65  ? 13.62628  -3.13519  42.01131  1.000 19.67803 ? 44  PHE   B CD2 1 
ATOM   3216 C CE1 . PHE   B 1 65  ? 15.13355  -1.45536  40.42652  1.000 20.80648 ? 44  PHE   B CE1 1 
ATOM   3217 C CE2 . PHE   B 1 65  ? 14.90198  -3.50636  41.62946  1.000 22.63176 ? 44  PHE   B CE2 1 
ATOM   3218 C CZ  . PHE   B 1 65  ? 15.65506  -2.66624  40.83496  1.000 19.99215 ? 44  PHE   B CZ  1 
ATOM   3219 N N   . PHE   B 1 66  ? 9.50614   -0.03776  44.06428  1.000 11.02552 ? 45  PHE   B N   1 
ATOM   3220 C CA  . PHE   B 1 66  ? 8.28630   0.73835   44.26906  1.000 15.53941 ? 45  PHE   B CA  1 
ATOM   3221 C C   . PHE   B 1 66  ? 8.60180   2.13684   44.78841  1.000 12.91975 ? 45  PHE   B C   1 
ATOM   3222 O O   . PHE   B 1 66  ? 7.84064   3.07662   44.53467  1.000 9.48378  ? 45  PHE   B O   1 
ATOM   3223 C CB  . PHE   B 1 66  ? 7.33223   0.01222   45.22153  1.000 13.08934 ? 45  PHE   B CB  1 
ATOM   3224 C CG  . PHE   B 1 66  ? 6.45643   -1.01087  44.54406  1.000 9.21784  ? 45  PHE   B CG  1 
ATOM   3225 C CD1 . PHE   B 1 66  ? 7.01320   -2.09304  43.88077  1.000 9.81521  ? 45  PHE   B CD1 1 
ATOM   3226 C CD2 . PHE   B 1 66  ? 5.07750   -0.87592  44.55147  1.000 10.78980 ? 45  PHE   B CD2 1 
ATOM   3227 C CE1 . PHE   B 1 66  ? 6.21023   -3.03364  43.25528  1.000 14.36092 ? 45  PHE   B CE1 1 
ATOM   3228 C CE2 . PHE   B 1 66  ? 4.26815   -1.81035  43.92391  1.000 9.42887  ? 45  PHE   B CE2 1 
ATOM   3229 C CZ  . PHE   B 1 66  ? 4.83547   -2.89113  43.27640  1.000 11.18631 ? 45  PHE   B CZ  1 
ATOM   3230 N N   . THR   B 1 67  ? 9.71711   2.29676   45.50720  1.000 14.94866 ? 46  THR   B N   1 
ATOM   3231 C CA  . THR   B 1 67  ? 10.13750  3.62158   45.95384  1.000 12.29015 ? 46  THR   B CA  1 
ATOM   3232 C C   . THR   B 1 67  ? 10.83745  4.39037   44.83939  1.000 15.51877 ? 46  THR   B C   1 
ATOM   3233 O O   . THR   B 1 67  ? 10.52797  5.56079   44.59263  1.000 19.52883 ? 46  THR   B O   1 
ATOM   3234 C CB  . THR   B 1 67  ? 11.06461  3.50607   47.16791  1.000 15.15315 ? 46  THR   B CB  1 
ATOM   3235 O OG1 . THR   B 1 67  ? 10.34932  2.93192   48.26769  1.000 11.35102 ? 46  THR   B OG1 1 
ATOM   3236 C CG2 . THR   B 1 67  ? 11.59068  4.87694   47.57136  1.000 16.95999 ? 46  THR   B CG2 1 
ATOM   3237 N N   . ASN   B 1 68  ? 11.77884  3.74439   44.14975  1.000 13.80532 ? 47  ASN   B N   1 
ATOM   3238 C CA  . ASN   B 1 68  ? 12.64288  4.44934   43.21095  1.000 21.46122 ? 47  ASN   B CA  1 
ATOM   3239 C C   . ASN   B 1 68  ? 11.91938  4.91913   41.95566  1.000 15.16161 ? 47  ASN   B C   1 
ATOM   3240 O O   . ASN   B 1 68  ? 12.46923  5.75316   41.22954  1.000 17.07348 ? 47  ASN   B O   1 
ATOM   3241 C CB  . ASN   B 1 68  ? 13.82799  3.56230   42.82505  1.000 20.96350 ? 47  ASN   B CB  1 
ATOM   3242 C CG  . ASN   B 1 68  ? 14.84137  3.42552   43.94737  1.000 25.89514 ? 47  ASN   B CG  1 
ATOM   3243 O OD1 . ASN   B 1 68  ? 14.64733  3.95370   45.04305  1.000 33.40750 ? 47  ASN   B OD1 1 
ATOM   3244 N ND2 . ASN   B 1 68  ? 15.92907  2.71374   43.67930  1.000 26.49189 ? 47  ASN   B ND2 1 
ATOM   3245 N N   . VAL   B 1 69  ? 10.70911  4.42174   41.68165  1.000 14.33053 ? 48  VAL   B N   1 
ATOM   3246 C CA  . VAL   B 1 69  ? 9.96038   4.89966   40.51976  1.000 18.64005 ? 48  VAL   B CA  1 
ATOM   3247 C C   . VAL   B 1 69  ? 9.32772   6.26116   40.75076  1.000 16.67562 ? 48  VAL   B C   1 
ATOM   3248 O O   . VAL   B 1 69  ? 8.80249   6.85547   39.79901  1.000 20.65245 ? 48  VAL   B O   1 
ATOM   3249 C CB  . VAL   B 1 69  ? 8.85278   3.91293   40.10560  1.000 20.20082 ? 48  VAL   B CB  1 
ATOM   3250 C CG1 . VAL   B 1 69  ? 9.45488   2.68087   39.44269  1.000 16.49126 ? 48  VAL   B CG1 1 
ATOM   3251 C CG2 . VAL   B 1 69  ? 7.99728   3.53829   41.30720  1.000 12.50693 ? 48  VAL   B CG2 1 
ATOM   3252 N N   . LYS   B 1 70  ? 9.35324   6.76288   41.98762  1.000 14.92990 ? 49  LYS   B N   1 
ATOM   3253 C CA  . LYS   B 1 70  ? 8.86461   8.10249   42.32559  1.000 19.32015 ? 49  LYS   B CA  1 
ATOM   3254 C C   . LYS   B 1 70  ? 7.37458   8.26084   42.01149  1.000 14.57656 ? 49  LYS   B C   1 
ATOM   3255 O O   . LYS   B 1 70  ? 6.94131   9.24919   41.41720  1.000 15.72191 ? 49  LYS   B O   1 
ATOM   3256 C CB  . LYS   B 1 70  ? 9.69309   9.18001   41.61968  1.000 22.83136 ? 49  LYS   B CB  1 
ATOM   3257 C CG  . LYS   B 1 70  ? 11.19926  9.04867   41.80620  1.000 23.77441 ? 49  LYS   B CG  1 
ATOM   3258 C CD  . LYS   B 1 70  ? 11.57750  9.09080   43.27426  1.000 25.93968 ? 49  LYS   B CD  1 
ATOM   3259 C CE  . LYS   B 1 70  ? 11.82068  10.51768  43.73750  1.000 32.05677 ? 49  LYS   B CE  1 
ATOM   3260 N NZ  . LYS   B 1 70  ? 12.26396  10.57155  45.15884  1.000 44.11249 ? 49  LYS   B NZ  1 
ATOM   3261 N N   . ILE   B 1 71  ? 6.58475   7.27821   42.43617  1.000 12.97670 ? 50  ILE   B N   1 
ATOM   3262 C CA  . ILE   B 1 71  ? 5.13510   7.28537   42.27617  1.000 12.01110 ? 50  ILE   B CA  1 
ATOM   3263 C C   . ILE   B 1 71  ? 4.50399   7.27433   43.66242  1.000 9.75583  ? 50  ILE   B C   1 
ATOM   3264 O O   . ILE   B 1 71  ? 4.86808   6.44743   44.50534  1.000 13.57401 ? 50  ILE   B O   1 
ATOM   3265 C CB  . ILE   B 1 71  ? 4.64986   6.07923   41.45043  1.000 8.27959  ? 50  ILE   B CB  1 
ATOM   3266 C CG1 . ILE   B 1 71  ? 5.18785   6.14921   40.01897  1.000 11.44013 ? 50  ILE   B CG1 1 
ATOM   3267 C CG2 . ILE   B 1 71  ? 3.13043   6.00107   41.46374  1.000 7.61634  ? 50  ILE   B CG2 1 
ATOM   3268 C CD1 . ILE   B 1 71  ? 5.03146   4.85498   39.24878  1.000 10.83053 ? 50  ILE   B CD1 1 
ATOM   3269 N N   . ASP   B 1 72  ? 3.55837   8.18552   43.89568  1.000 8.63545  ? 51  ASP   B N   1 
ATOM   3270 C CA  . ASP   B 1 72  ? 2.88707   8.26637   45.18860  1.000 14.26342 ? 51  ASP   B CA  1 
ATOM   3271 C C   . ASP   B 1 72  ? 1.63230   7.40834   45.26054  1.000 13.47875 ? 51  ASP   B C   1 
ATOM   3272 O O   . ASP   B 1 72  ? 1.25294   6.97004   46.35390  1.000 11.85606 ? 51  ASP   B O   1 
ATOM   3273 C CB  . ASP   B 1 72  ? 2.53193   9.72181   45.50760  1.000 17.20896 ? 51  ASP   B CB  1 
ATOM   3274 C CG  . ASP   B 1 72  ? 3.75886   10.57668  45.75277  1.000 18.54238 ? 51  ASP   B CG  1 
ATOM   3275 O OD1 . ASP   B 1 72  ? 4.77730   10.02548  46.22036  1.000 17.22315 ? 51  ASP   B OD1 1 
ATOM   3276 O OD2 . ASP   B 1 72  ? 3.71099   11.79160  45.46335  1.000 19.10584 ? 51  ASP   B OD2 1 
ATOM   3277 N N   . GLY   B 1 73  ? 0.98491   7.16190   44.12896  1.000 10.18832 ? 52  GLY   B N   1 
ATOM   3278 C CA  . GLY   B 1 73  ? -0.21635  6.34898   44.10948  1.000 7.48843  ? 52  GLY   B CA  1 
ATOM   3279 C C   . GLY   B 1 73  ? -0.69979  6.18676   42.68462  1.000 8.97005  ? 52  GLY   B C   1 
ATOM   3280 O O   . GLY   B 1 73  ? -0.29591  6.92550   41.78156  1.000 10.61419 ? 52  GLY   B O   1 
ATOM   3281 N N   . ARG   B 1 74  ? -1.58015  5.20280   42.50138  1.000 9.79007  ? 53  ARG   B N   1 
ATOM   3282 C CA  . ARG   B 1 74  ? -2.03227  4.80873   41.17340  1.000 12.47946 ? 53  ARG   B CA  1 
ATOM   3283 C C   . ARG   B 1 74  ? -3.50156  4.41453   41.20420  1.000 8.69292  ? 53  ARG   B C   1 
ATOM   3284 O O   . ARG   B 1 74  ? -3.99515  3.86742   42.19172  1.000 8.92683  ? 53  ARG   B O   1 
ATOM   3285 C CB  . ARG   B 1 74  ? -1.20148  3.63750   40.62401  1.000 7.46820  ? 53  ARG   B CB  1 
ATOM   3286 C CG  . ARG   B 1 74  ? 0.26502   3.97295   40.40693  1.000 6.80871  ? 53  ARG   B CG  1 
ATOM   3287 C CD  . ARG   B 1 74  ? 1.05250   2.79742   39.86921  1.000 9.91302  ? 53  ARG   B CD  1 
ATOM   3288 N NE  . ARG   B 1 74  ? 1.67233   2.01561   40.93275  1.000 8.24268  ? 53  ARG   B NE  1 
ATOM   3289 C CZ  . ARG   B 1 74  ? 1.99655   0.73531   40.82129  1.000 9.16008  ? 53  ARG   B CZ  1 
ATOM   3290 N NH1 . ARG   B 1 74  ? 1.77995   0.06306   39.70188  1.000 9.79219  ? 53  ARG   B NH1 1 
ATOM   3291 N NH2 . ARG   B 1 74  ? 2.55851   0.11587   41.85480  1.000 6.58023  ? 53  ARG   B NH2 1 
ATOM   3292 N N   . TYR   B 1 75  ? -4.19361  4.68957   40.10028  1.000 12.09301 ? 54  TYR   B N   1 
ATOM   3293 C CA  . TYR   B 1 75  ? -5.55019  4.20032   39.89048  1.000 9.92424  ? 54  TYR   B CA  1 
ATOM   3294 C C   . TYR   B 1 75  ? -5.50825  2.79275   39.31051  1.000 8.90309  ? 54  TYR   B C   1 
ATOM   3295 O O   . TYR   B 1 75  ? -4.79745  2.53923   38.33383  1.000 8.96990  ? 54  TYR   B O   1 
ATOM   3296 C CB  . TYR   B 1 75  ? -6.33046  5.11724   38.94852  1.000 10.80611 ? 54  TYR   B CB  1 
ATOM   3297 C CG  . TYR   B 1 75  ? -6.70695  6.46173   39.52032  1.000 9.15523  ? 54  TYR   B CG  1 
ATOM   3298 C CD1 . TYR   B 1 75  ? -7.83155  6.60157   40.32554  1.000 12.40544 ? 54  TYR   B CD1 1 
ATOM   3299 C CD2 . TYR   B 1 75  ? -5.95244  7.59489   39.24225  1.000 9.21230  ? 54  TYR   B CD2 1 
ATOM   3300 C CE1 . TYR   B 1 75  ? -8.19121  7.83300   40.84305  1.000 11.19748 ? 54  TYR   B CE1 1 
ATOM   3301 C CE2 . TYR   B 1 75  ? -6.30596  8.83095   39.75322  1.000 12.80186 ? 54  TYR   B CE2 1 
ATOM   3302 C CZ  . TYR   B 1 75  ? -7.42560  8.94312   40.55410  1.000 18.61119 ? 54  TYR   B CZ  1 
ATOM   3303 O OH  . TYR   B 1 75  ? -7.78008  10.16984  41.06927  1.000 18.69191 ? 54  TYR   B OH  1 
ATOM   3304 N N   . PHE   B 1 76  ? -6.26823  1.88316   39.91519  1.000 7.55567  ? 55  PHE   B N   1 
ATOM   3305 C CA  . PHE   B 1 76  ? -6.44849  0.52969   39.40412  1.000 10.17637 ? 55  PHE   B CA  1 
ATOM   3306 C C   . PHE   B 1 76  ? -7.92482  0.32225   39.10105  1.000 13.80198 ? 55  PHE   B C   1 
ATOM   3307 O O   . PHE   B 1 76  ? -8.76157  0.38976   40.00713  1.000 9.80629  ? 55  PHE   B O   1 
ATOM   3308 C CB  . PHE   B 1 76  ? -5.95880  -0.51381  40.41035  1.000 9.43310  ? 55  PHE   B CB  1 
ATOM   3309 C CG  . PHE   B 1 76  ? -4.49723  -0.84598  40.28874  1.000 11.87439 ? 55  PHE   B CG  1 
ATOM   3310 C CD1 . PHE   B 1 76  ? -3.60527  0.05479   39.73029  1.000 14.94433 ? 55  PHE   B CD1 1 
ATOM   3311 C CD2 . PHE   B 1 76  ? -4.01218  -2.05646  40.75700  1.000 14.23658 ? 55  PHE   B CD2 1 
ATOM   3312 C CE1 . PHE   B 1 76  ? -2.25993  -0.25295  39.62693  1.000 11.25586 ? 55  PHE   B CE1 1 
ATOM   3313 C CE2 . PHE   B 1 76  ? -2.66833  -2.36661  40.65946  1.000 12.25944 ? 55  PHE   B CE2 1 
ATOM   3314 C CZ  . PHE   B 1 76  ? -1.79308  -1.46503  40.09146  1.000 11.56082 ? 55  PHE   B CZ  1 
ATOM   3315 N N   . ALA   B 1 77  ? -8.24494  0.07174   37.82942  1.000 9.12365  ? 56  ALA   B N   1 
ATOM   3316 C CA  . ALA   B 1 77  ? -9.62438  -0.23368  37.46972  1.000 12.17423 ? 56  ALA   B CA  1 
ATOM   3317 C C   . ALA   B 1 77  ? -10.02237 -1.64328  37.88803  1.000 16.14430 ? 56  ALA   B C   1 
ATOM   3318 O O   . ALA   B 1 77  ? -11.17918 -1.87245  38.25894  1.000 11.76520 ? 56  ALA   B O   1 
ATOM   3319 C CB  . ALA   B 1 77  ? -9.83231  -0.05234  35.96407  1.000 11.94414 ? 56  ALA   B CB  1 
ATOM   3320 N N   . LEU   B 1 78  ? -9.08268  -2.59169  37.84754  1.000 11.59526 ? 57  LEU   B N   1 
ATOM   3321 C CA  . LEU   B 1 78  ? -9.32513  -3.99577  38.13097  1.000 14.12313 ? 57  LEU   B CA  1 
ATOM   3322 C C   . LEU   B 1 78  ? -8.91151  -4.33190  39.56261  1.000 14.70558 ? 57  LEU   B C   1 
ATOM   3323 O O   . LEU   B 1 78  ? -8.06974  -3.64303  40.14568  1.000 14.37670 ? 57  LEU   B O   1 
ATOM   3324 C CB  . LEU   B 1 78  ? -8.56264  -4.87410  37.13115  1.000 10.85391 ? 57  LEU   B CB  1 
ATOM   3325 C CG  . LEU   B 1 78  ? -8.99877  -4.63253  35.68016  1.000 12.46829 ? 57  LEU   B CG  1 
ATOM   3326 C CD1 . LEU   B 1 78  ? -8.36866  -5.63673  34.72334  1.000 12.18329 ? 57  LEU   B CD1 1 
ATOM   3327 C CD2 . LEU   B 1 78  ? -10.51694 -4.64551  35.55914  1.000 13.59479 ? 57  LEU   B CD2 1 
ATOM   3328 N N   . PRO   B 1 79  ? -9.49460  -5.37189  40.16519  1.000 16.09673 ? 58  PRO   B N   1 
ATOM   3329 C CA  . PRO   B 1 79  ? -9.34952  -5.55959  41.61538  1.000 24.46944 ? 58  PRO   B CA  1 
ATOM   3330 C C   . PRO   B 1 79  ? -7.92737  -5.88241  42.04684  1.000 23.05768 ? 58  PRO   B C   1 
ATOM   3331 O O   . PRO   B 1 79  ? -7.16044  -6.53804  41.33661  1.000 17.35765 ? 58  PRO   B O   1 
ATOM   3332 C CB  . PRO   B 1 79  ? -10.29027 -6.73270  41.92661  1.000 24.34213 ? 58  PRO   B CB  1 
ATOM   3333 C CG  . PRO   B 1 79  ? -11.09085 -6.96490  40.69866  1.000 25.88306 ? 58  PRO   B CG  1 
ATOM   3334 C CD  . PRO   B 1 79  ? -10.31480 -6.42965  39.55160  1.000 15.55395 ? 58  PRO   B CD  1 
ATOM   3335 N N   . LEU   B 1 80  ? -7.59234  -5.41326  43.25105  1.000 21.96964 ? 59  LEU   B N   1 
ATOM   3336 C CA  . LEU   B 1 80  ? -6.30959  -5.72305  43.87014  1.000 27.07699 ? 59  LEU   B CA  1 
ATOM   3337 C C   . LEU   B 1 80  ? -6.30232  -7.10278  44.51672  1.000 37.07568 ? 59  LEU   B C   1 
ATOM   3338 O O   . LEU   B 1 80  ? -5.23843  -7.72216  44.63131  1.000 36.91812 ? 59  LEU   B O   1 
ATOM   3339 C CB  . LEU   B 1 80  ? -5.96725  -4.65811  44.91284  1.000 24.23474 ? 59  LEU   B CB  1 
ATOM   3340 C CG  . LEU   B 1 80  ? -4.50090  -4.47728  45.30073  1.000 28.66889 ? 59  LEU   B CG  1 
ATOM   3341 C CD1 . LEU   B 1 80  ? -3.60114  -4.48394  44.07280  1.000 25.93279 ? 59  LEU   B CD1 1 
ATOM   3342 C CD2 . LEU   B 1 80  ? -4.33225  -3.19058  46.09113  1.000 23.50901 ? 59  LEU   B CD2 1 
ATOM   3343 N N   . ASP   B 1 81  ? -7.46774  -7.59631  44.94448  1.000 38.24980 ? 60  ASP   B N   1 
ATOM   3344 C CA  . ASP   B 1 81  ? -7.55492  -8.89832  45.59676  1.000 43.25801 ? 60  ASP   B CA  1 
ATOM   3345 C C   . ASP   B 1 81  ? -7.36104  -10.05662 44.62642  1.000 42.72544 ? 60  ASP   B C   1 
ATOM   3346 O O   . ASP   B 1 81  ? -7.22221  -11.20049 45.07253  1.000 43.00336 ? 60  ASP   B O   1 
ATOM   3347 C CB  . ASP   B 1 81  ? -8.89996  -9.03519  46.31662  1.000 49.14218 ? 60  ASP   B CB  1 
ATOM   3348 C CG  . ASP   B 1 81  ? -8.85294  -10.03243 47.46449  1.000 60.15689 ? 60  ASP   B CG  1 
ATOM   3349 O OD1 . ASP   B 1 81  ? -8.96899  -11.25010 47.20864  1.000 58.96803 ? 60  ASP   B OD1 1 
ATOM   3350 O OD2 . ASP   B 1 81  ? -8.69998  -9.59719  48.62657  1.000 51.35895 ? 60  ASP   B OD2 1 
ATOM   3351 N N   . SER   B 1 82  ? -7.33455  -9.79208  43.31894  1.000 40.85050 ? 61  SER   B N   1 
ATOM   3352 C CA  . SER   B 1 82  ? -7.03050  -10.83501 42.34751  1.000 37.33225 ? 61  SER   B CA  1 
ATOM   3353 C C   . SER   B 1 82  ? -5.59429  -11.32691 42.45807  1.000 33.30331 ? 61  SER   B C   1 
ATOM   3354 O O   . SER   B 1 82  ? -5.25360  -12.33850 41.83528  1.000 31.19797 ? 61  SER   B O   1 
ATOM   3355 C CB  . SER   B 1 82  ? -7.29894  -10.32731 40.93031  1.000 24.39525 ? 61  SER   B CB  1 
ATOM   3356 O OG  . SER   B 1 82  ? -8.65634  -9.95112  40.77712  1.000 30.98060 ? 61  SER   B OG  1 
ATOM   3357 N N   . LEU   B 1 83  ? -4.75321  -10.63103 43.22808  1.000 34.34486 ? 62  LEU   B N   1 
ATOM   3358 C CA  . LEU   B 1 83  ? -3.37424  -11.06298 43.42516  1.000 35.36041 ? 62  LEU   B CA  1 
ATOM   3359 C C   . LEU   B 1 83  ? -3.31417  -12.46319 44.02541  1.000 32.55847 ? 62  LEU   B C   1 
ATOM   3360 O O   . LEU   B 1 83  ? -2.53532  -13.30959 43.57117  1.000 29.52640 ? 62  LEU   B O   1 
ATOM   3361 C CB  . LEU   B 1 83  ? -2.65095  -10.06460 44.33151  1.000 33.16335 ? 62  LEU   B CB  1 
ATOM   3362 C CG  . LEU   B 1 83  ? -1.69107  -9.04275  43.71490  1.000 24.13897 ? 62  LEU   B CG  1 
ATOM   3363 C CD1 . LEU   B 1 83  ? -0.74711  -8.48297  44.77112  1.000 20.51896 ? 62  LEU   B CD1 1 
ATOM   3364 C CD2 . LEU   B 1 83  ? -0.90854  -9.63412  42.56217  1.000 28.04889 ? 62  LEU   B CD2 1 
ATOM   3365 N N   . LEU   B 1 84  ? -4.14203  -12.73107 45.03744  1.000 34.43148 ? 63  LEU   B N   1 
ATOM   3366 C CA  . LEU   B 1 84  ? -4.06347  -14.00158 45.75110  1.000 35.58296 ? 63  LEU   B CA  1 
ATOM   3367 C C   . LEU   B 1 84  ? -4.80265  -15.11167 45.01096  1.000 36.92883 ? 63  LEU   B C   1 
ATOM   3368 O O   . LEU   B 1 84  ? -4.26279  -16.20831 44.82855  1.000 43.47988 ? 63  LEU   B O   1 
ATOM   3369 C CB  . LEU   B 1 84  ? -4.60865  -13.83428 47.16970  1.000 41.27553 ? 63  LEU   B CB  1 
ATOM   3370 C CG  . LEU   B 1 84  ? -3.92398  -12.73329 47.98165  1.000 40.14647 ? 63  LEU   B CG  1 
ATOM   3371 C CD1 . LEU   B 1 84  ? -4.73625  -12.38551 49.22067  1.000 37.70372 ? 63  LEU   B CD1 1 
ATOM   3372 C CD2 . LEU   B 1 84  ? -2.50419  -13.14515 48.35424  1.000 35.04779 ? 63  LEU   B CD2 1 
ATOM   3373 N N   . ASP   B 1 85  ? -6.03539  -14.85567 44.58749  1.000 34.71982 ? 64  ASP   B N   1 
ATOM   3374 C CA  . ASP   B 1 85  ? -6.76848  -15.77888 43.72099  1.000 39.12969 ? 64  ASP   B CA  1 
ATOM   3375 C C   . ASP   B 1 85  ? -7.22658  -15.02924 42.47470  1.000 44.11436 ? 64  ASP   B C   1 
ATOM   3376 O O   . ASP   B 1 85  ? -8.07691  -14.11997 42.57044  1.000 37.89920 ? 64  ASP   B O   1 
ATOM   3377 C CB  . ASP   B 1 85  ? -7.93136  -16.44562 44.45861  1.000 43.48963 ? 64  ASP   B CB  1 
ATOM   3378 C CG  . ASP   B 1 85  ? -9.05281  -15.48579 44.80322  1.000 43.42988 ? 64  ASP   B CG  1 
ATOM   3379 O OD1 . ASP   B 1 85  ? -8.75620  -14.36178 45.26054  1.000 43.44281 ? 64  ASP   B OD1 1 
ATOM   3380 O OD2 . ASP   B 1 85  ? -10.23087 -15.85466 44.60879  1.000 35.81258 ? 64  ASP   B OD2 1 
ATOM   3381 N N   . PRO   B 1 86  ? -6.67593  -15.34014 41.30636  1.000 40.39304 ? 65  PRO   B N   1 
ATOM   3382 C CA  . PRO   B 1 86  ? -7.01133  -14.58417 40.10099  1.000 34.38924 ? 65  PRO   B CA  1 
ATOM   3383 C C   . PRO   B 1 86  ? -8.19726  -15.19748 39.38050  1.000 36.29607 ? 65  PRO   B C   1 
ATOM   3384 O O   . PRO   B 1 86  ? -8.37628  -16.42472 39.38957  1.000 36.59186 ? 65  PRO   B O   1 
ATOM   3385 C CB  . PRO   B 1 86  ? -5.73252  -14.68803 39.25072  1.000 31.63213 ? 65  PRO   B CB  1 
ATOM   3386 C CG  . PRO   B 1 86  ? -4.74042  -15.49930 40.07732  1.000 32.58134 ? 65  PRO   B CG  1 
ATOM   3387 C CD  . PRO   B 1 86  ? -5.55139  -16.25498 41.07276  1.000 33.93327 ? 65  PRO   B CD  1 
ATOM   3388 N N   . PRO   B 1 87  ? -9.03093  -14.37564 38.73840  1.000 37.00233 ? 66  PRO   B N   1 
ATOM   3389 C CA  . PRO   B 1 87  ? -10.11231 -14.92394 37.90940  1.000 35.03999 ? 66  PRO   B CA  1 
ATOM   3390 C C   . PRO   B 1 87  ? -9.58565  -15.48840 36.59984  1.000 33.40283 ? 66  PRO   B C   1 
ATOM   3391 O O   . PRO   B 1 87  ? -8.37139  -15.52515 36.37794  1.000 35.76726 ? 66  PRO   B O   1 
ATOM   3392 C CB  . PRO   B 1 87  ? -11.02690 -13.71501 37.67765  1.000 37.30333 ? 66  PRO   B CB  1 
ATOM   3393 C CG  . PRO   B 1 87  ? -10.12697 -12.53315 37.80005  1.000 31.33945 ? 66  PRO   B CG  1 
ATOM   3394 C CD  . PRO   B 1 87  ? -9.04753  -12.90241 38.78242  1.000 32.21681 ? 66  PRO   B CD  1 
ATOM   3395 N N   . THR   B 1 88  ? -10.48712 -15.92817 35.72595  1.000 28.79761 ? 67  THR   B N   1 
ATOM   3396 C CA  . THR   B 1 88  ? -10.07868 -16.51209 34.45856  1.000 27.93753 ? 67  THR   B CA  1 
ATOM   3397 C C   . THR   B 1 88  ? -9.57519  -15.43180 33.50221  1.000 32.85073 ? 67  THR   B C   1 
ATOM   3398 O O   . THR   B 1 88  ? -9.78878  -14.23164 33.69856  1.000 24.87451 ? 67  THR   B O   1 
ATOM   3399 C CB  . THR   B 1 88  ? -11.23602 -17.27053 33.81103  1.000 32.56541 ? 67  THR   B CB  1 
ATOM   3400 O OG1 . THR   B 1 88  ? -12.29297 -16.35425 33.49975  1.000 26.59805 ? 67  THR   B OG1 1 
ATOM   3401 C CG2 . THR   B 1 88  ? -11.76407 -18.34430 34.75140  1.000 34.58934 ? 67  THR   B CG2 1 
ATOM   3402 N N   . TRP   B 1 89  ? -8.89739  -15.89012 32.44631  1.000 34.04788 ? 68  TRP   B N   1 
ATOM   3403 C CA  . TRP   B 1 89  ? -8.39336  -14.99223 31.41029  1.000 34.68824 ? 68  TRP   B CA  1 
ATOM   3404 C C   . TRP   B 1 89  ? -9.51705  -14.16916 30.79423  1.000 31.76578 ? 68  TRP   B C   1 
ATOM   3405 O O   . TRP   B 1 89  ? -9.42552  -12.93828 30.70266  1.000 27.36451 ? 68  TRP   B O   1 
ATOM   3406 C CB  . TRP   B 1 89  ? -7.69041  -15.80811 30.32657  1.000 40.17910 ? 68  TRP   B CB  1 
ATOM   3407 C CG  . TRP   B 1 89  ? -6.24303  -16.05450 30.56001  1.000 51.53453 ? 68  TRP   B CG  1 
ATOM   3408 C CD1 . TRP   B 1 89  ? -5.58865  -16.06075 31.75595  1.000 51.04662 ? 68  TRP   B CD1 1 
ATOM   3409 C CD2 . TRP   B 1 89  ? -5.27222  -16.39760 29.56848  1.000 49.96338 ? 68  TRP   B CD2 1 
ATOM   3410 N NE1 . TRP   B 1 89  ? -4.25904  -16.35327 31.56552  1.000 49.46358 ? 68  TRP   B NE1 1 
ATOM   3411 C CE2 . TRP   B 1 89  ? -4.04114  -16.56870 30.23024  1.000 48.51819 ? 68  TRP   B CE2 1 
ATOM   3412 C CE3 . TRP   B 1 89  ? -5.32237  -16.56447 28.18163  1.000 51.86942 ? 68  TRP   B CE3 1 
ATOM   3413 C CZ2 . TRP   B 1 89  ? -2.87178  -16.90137 29.55338  1.000 43.05131 ? 68  TRP   B CZ2 1 
ATOM   3414 C CZ3 . TRP   B 1 89  ? -4.16411  -16.89334 27.51372  1.000 52.34810 ? 68  TRP   B CZ3 1 
ATOM   3415 C CH2 . TRP   B 1 89  ? -2.95198  -17.05506 28.19709  1.000 46.19722 ? 68  TRP   B CH2 1 
ATOM   3416 N N   . GLY   B 1 90  ? -10.58477 -14.84056 30.35570  1.000 35.67243 ? 69  GLY   B N   1 
ATOM   3417 C CA  . GLY   B 1 90  ? -11.65716 -14.14419 29.66368  1.000 31.61141 ? 69  GLY   B CA  1 
ATOM   3418 C C   . GLY   B 1 90  ? -12.38972 -13.15553 30.54917  1.000 29.23820 ? 69  GLY   B C   1 
ATOM   3419 O O   . GLY   B 1 90  ? -12.82739 -12.09772 30.08688  1.000 31.33327 ? 69  GLY   B O   1 
ATOM   3420 N N   . VAL   B 1 91  ? -12.54412 -13.48975 31.83137  1.000 32.50851 ? 70  VAL   B N   1 
ATOM   3421 C CA  . VAL   B 1 91  ? -13.20673 -12.57842 32.76161  1.000 31.34135 ? 70  VAL   B CA  1 
ATOM   3422 C C   . VAL   B 1 91  ? -12.39302 -11.29905 32.91834  1.000 20.56487 ? 70  VAL   B C   1 
ATOM   3423 O O   . VAL   B 1 91  ? -12.93184 -10.18622 32.86577  1.000 19.66786 ? 70  VAL   B O   1 
ATOM   3424 C CB  . VAL   B 1 91  ? -13.44146 -13.27475 34.11448  1.000 24.91326 ? 70  VAL   B CB  1 
ATOM   3425 C CG1 . VAL   B 1 91  ? -13.60627 -12.25603 35.23024  1.000 23.47895 ? 70  VAL   B CG1 1 
ATOM   3426 C CG2 . VAL   B 1 91  ? -14.65761 -14.18640 34.03185  1.000 33.08589 ? 70  VAL   B CG2 1 
ATOM   3427 N N   . SER   B 1 92  ? -11.07747 -11.43996 33.09943  1.000 20.63324 ? 71  SER   B N   1 
ATOM   3428 C CA  . SER   B 1 92  ? -10.21380 -10.26719 33.19128  1.000 23.48067 ? 71  SER   B CA  1 
ATOM   3429 C C   . SER   B 1 92  ? -10.19140 -9.49714  31.87734  1.000 19.47701 ? 71  SER   B C   1 
ATOM   3430 O O   . SER   B 1 92  ? -10.16788 -8.26073  31.87460  1.000 12.21957 ? 71  SER   B O   1 
ATOM   3431 C CB  . SER   B 1 92  ? -8.80100  -10.68626 33.59553  1.000 20.74677 ? 71  SER   B CB  1 
ATOM   3432 O OG  . SER   B 1 92  ? -8.76078  -11.06717 34.96069  1.000 28.96474 ? 71  SER   B OG  1 
ATOM   3433 N N   . ILE   B 1 93  ? -10.19600 -10.21235 30.75091  1.000 18.21615 ? 72  ILE   B N   1 
ATOM   3434 C CA  . ILE   B 1 93  ? -10.23102 -9.55052  29.45078  1.000 19.30281 ? 72  ILE   B CA  1 
ATOM   3435 C C   . ILE   B 1 93  ? -11.53812 -8.78454  29.28223  1.000 16.37860 ? 72  ILE   B C   1 
ATOM   3436 O O   . ILE   B 1 93  ? -11.55037 -7.64347  28.80264  1.000 20.78041 ? 72  ILE   B O   1 
ATOM   3437 C CB  . ILE   B 1 93  ? -10.01698 -10.58177 28.32678  1.000 31.07963 ? 72  ILE   B CB  1 
ATOM   3438 C CG1 . ILE   B 1 93  ? -8.52299  -10.85569 28.14621  1.000 25.75651 ? 72  ILE   B CG1 1 
ATOM   3439 C CG2 . ILE   B 1 93  ? -10.63229 -10.09684 27.01915  1.000 34.72285 ? 72  ILE   B CG2 1 
ATOM   3440 C CD1 . ILE   B 1 93  ? -7.77771  -9.73382  27.46400  1.000 30.07635 ? 72  ILE   B CD1 1 
ATOM   3441 N N   . SER   B 1 94  ? -12.65750 -9.39416  29.68328  1.000 18.80272 ? 73  SER   B N   1 
ATOM   3442 C CA  . SER   B 1 94  ? -13.94276 -8.70456  29.61539  1.000 14.19697 ? 73  SER   B CA  1 
ATOM   3443 C C   . SER   B 1 94  ? -13.95782 -7.47438  30.51471  1.000 18.80749 ? 73  SER   B C   1 
ATOM   3444 O O   . SER   B 1 94  ? -14.42973 -6.40533  30.10939  1.000 14.85887 ? 73  SER   B O   1 
ATOM   3445 C CB  . SER   B 1 94  ? -15.07244 -9.66010  30.00250  1.000 17.04619 ? 73  SER   B CB  1 
ATOM   3446 O OG  . SER   B 1 94  ? -15.07597 -10.81030 29.17481  1.000 32.14213 ? 73  SER   B OG  1 
ATOM   3447 N N   . ARG   B 1 95  ? -13.44043 -7.60662  31.73938  1.000 18.00512 ? 74  ARG   B N   1 
ATOM   3448 C CA  . ARG   B 1 95  ? -13.42286 -6.47915  32.66658  1.000 17.90617 ? 74  ARG   B CA  1 
ATOM   3449 C C   . ARG   B 1 95  ? -12.56058 -5.33903  32.14162  1.000 10.52720 ? 74  ARG   B C   1 
ATOM   3450 O O   . ARG   B 1 95  ? -12.93687 -4.16639  32.24942  1.000 14.81492 ? 74  ARG   B O   1 
ATOM   3451 C CB  . ARG   B 1 95  ? -12.91796 -6.93156  34.03597  1.000 14.86736 ? 74  ARG   B CB  1 
ATOM   3452 C CG  . ARG   B 1 95  ? -13.91871 -7.71829  34.85276  1.000 25.50078 ? 74  ARG   B CG  1 
ATOM   3453 C CD  . ARG   B 1 95  ? -13.22776 -8.35227  36.04729  1.000 29.16702 ? 74  ARG   B CD  1 
ATOM   3454 N NE  . ARG   B 1 95  ? -14.13418 -9.16486  36.84827  1.000 30.73508 ? 74  ARG   B NE  1 
ATOM   3455 C CZ  . ARG   B 1 95  ? -13.80330 -9.73778  37.99722  1.000 31.64560 ? 74  ARG   B CZ  1 
ATOM   3456 N NH1 . ARG   B 1 95  ? -12.58923 -9.60950  38.50907  1.000 28.54975 ? 74  ARG   B NH1 1 
ATOM   3457 N NH2 . ARG   B 1 95  ? -14.71185 -10.45892 38.64758  1.000 27.50320 ? 74  ARG   B NH2 1 
ATOM   3458 N N   . GLY   B 1 96  ? -11.38860 -5.66009  31.59236  1.000 11.77369 ? 75  GLY   B N   1 
ATOM   3459 C CA  . GLY   B 1 96  ? -10.54632 -4.62023  31.02692  1.000 11.01300 ? 75  GLY   B CA  1 
ATOM   3460 C C   . GLY   B 1 96  ? -11.20979 -3.91332  29.86249  1.000 12.51630 ? 75  GLY   B C   1 
ATOM   3461 O O   . GLY   B 1 96  ? -11.11871 -2.69064  29.72970  1.000 10.40395 ? 75  GLY   B O   1 
ATOM   3462 N N   . LEU   B 1 97  ? -11.89244 -4.67500  29.00671  1.000 15.05826 ? 76  LEU   B N   1 
ATOM   3463 C CA  . LEU   B 1 97  ? -12.60405 -4.07935  27.88230  1.000 12.48954 ? 76  LEU   B CA  1 
ATOM   3464 C C   . LEU   B 1 97  ? -13.72266 -3.16126  28.36460  1.000 13.10032 ? 76  LEU   B C   1 
ATOM   3465 O O   . LEU   B 1 97  ? -13.88745 -2.04591  27.85554  1.000 13.39133 ? 76  LEU   B O   1 
ATOM   3466 C CB  . LEU   B 1 97  ? -13.15961 -5.18740  26.98891  1.000 10.52925 ? 76  LEU   B CB  1 
ATOM   3467 C CG  . LEU   B 1 97  ? -14.03200 -4.79065  25.80207  1.000 22.77607 ? 76  LEU   B CG  1 
ATOM   3468 C CD1 . LEU   B 1 97  ? -13.25777 -3.86346  24.88767  1.000 15.93503 ? 76  LEU   B CD1 1 
ATOM   3469 C CD2 . LEU   B 1 97  ? -14.49979 -6.03124  25.05523  1.000 25.44516 ? 76  LEU   B CD2 1 
ATOM   3470 N N   . GLU   B 1 98  ? -14.49413 -3.61155  29.35768  1.000 13.73821 ? 77  GLU   B N   1 
ATOM   3471 C CA  . GLU   B 1 98  ? -15.60330 -2.81006  29.86669  1.000 13.69360 ? 77  GLU   B CA  1 
ATOM   3472 C C   . GLU   B 1 98  ? -15.10689 -1.54658  30.56093  1.000 14.29454 ? 77  GLU   B C   1 
ATOM   3473 O O   . GLU   B 1 98  ? -15.67788 -0.46493  30.37791  1.000 9.78863  ? 77  GLU   B O   1 
ATOM   3474 C CB  . GLU   B 1 98  ? -16.45438 -3.65065  30.82018  1.000 16.88565 ? 77  GLU   B CB  1 
ATOM   3475 C CG  . GLU   B 1 98  ? -17.85615 -3.11157  31.04479  1.000 31.82113 ? 77  GLU   B CG  1 
ATOM   3476 C CD  . GLU   B 1 98  ? -18.49427 -2.59115  29.77086  1.000 31.21070 ? 77  GLU   B CD  1 
ATOM   3477 O OE1 . GLU   B 1 98  ? -18.54020 -3.34831  28.77496  1.000 28.71468 ? 77  GLU   B OE1 1 
ATOM   3478 O OE2 . GLU   B 1 98  ? -18.94205 -1.42360  29.76416  1.000 29.78360 ? 77  GLU   B OE2 1 
ATOM   3479 N N   . ASN   B 1 99  ? -14.04942 -1.66472  31.36803  1.000 9.11297  ? 78  ASN   B N   1 
ATOM   3480 C CA  . ASN   B 1 99  ? -13.50015 -0.49613  32.05052  1.000 13.10936 ? 78  ASN   B CA  1 
ATOM   3481 C C   . ASN   B 1 99  ? -12.90252 0.50120   31.06442  1.000 10.66970 ? 78  ASN   B C   1 
ATOM   3482 O O   . ASN   B 1 99  ? -13.03223 1.71770   31.25090  1.000 8.38575  ? 78  ASN   B O   1 
ATOM   3483 C CB  . ASN   B 1 99  ? -12.45567 -0.93294  33.07667  1.000 11.03280 ? 78  ASN   B CB  1 
ATOM   3484 C CG  . ASN   B 1 99  ? -13.07665 -1.37067  34.38628  1.000 10.89178 ? 78  ASN   B CG  1 
ATOM   3485 O OD1 . ASN   B 1 99  ? -13.38993 -0.54271  35.24131  1.000 15.40069 ? 78  ASN   B OD1 1 
ATOM   3486 N ND2 . ASN   B 1 99  ? -13.26249 -2.67567  34.54979  1.000 12.50010 ? 78  ASN   B ND2 1 
ATOM   3487 N N   . SER   B 1 100 ? -12.23578 0.00857   30.01582  1.000 7.94888  ? 79  SER   B N   1 
ATOM   3488 C CA  . SER   B 1 100 ? -11.69900 0.90507   28.99522  1.000 9.38068  ? 79  SER   B CA  1 
ATOM   3489 C C   . SER   B 1 100 ? -12.80990 1.70114   28.32310  1.000 11.86724 ? 79  SER   B C   1 
ATOM   3490 O O   . SER   B 1 100 ? -12.67636 2.91318   28.11121  1.000 8.42439  ? 79  SER   B O   1 
ATOM   3491 C CB  . SER   B 1 100 ? -10.91670 0.10785   27.94987  1.000 9.21226  ? 79  SER   B CB  1 
ATOM   3492 O OG  . SER   B 1 100 ? -9.78860  -0.52618  28.51881  1.000 10.40213 ? 79  SER   B OG  1 
ATOM   3493 N N   . LEU   B 1 101 ? -13.91445 1.03397   27.97863  1.000 9.00345  ? 80  LEU   B N   1 
ATOM   3494 C CA  . LEU   B 1 101 ? -15.04371 1.73075   27.37220  1.000 12.65458 ? 80  LEU   B CA  1 
ATOM   3495 C C   . LEU   B 1 101 ? -15.63231 2.76529   28.32093  1.000 10.03940 ? 80  LEU   B C   1 
ATOM   3496 O O   . LEU   B 1 101 ? -15.97555 3.87614   27.90129  1.000 9.15341  ? 80  LEU   B O   1 
ATOM   3497 C CB  . LEU   B 1 101 ? -16.11732 0.72877   26.95301  1.000 15.82293 ? 80  LEU   B CB  1 
ATOM   3498 C CG  . LEU   B 1 101 ? -15.79693 -0.12950  25.73249  1.000 13.68191 ? 80  LEU   B CG  1 
ATOM   3499 C CD1 . LEU   B 1 101 ? -16.86140 -1.20451  25.55901  1.000 20.70242 ? 80  LEU   B CD1 1 
ATOM   3500 C CD2 . LEU   B 1 101 ? -15.70611 0.74767   24.49502  1.000 11.34768 ? 80  LEU   B CD2 1 
ATOM   3501 N N   . ASN   B 1 102 ? -15.77004 2.41543   29.60203  1.000 10.71572 ? 81  ASN   B N   1 
ATOM   3502 C CA  . ASN   B 1 102 ? -16.35942 3.34464   30.56095  1.000 8.26458  ? 81  ASN   B CA  1 
ATOM   3503 C C   . ASN   B 1 102 ? -15.50967 4.60250   30.69993  1.000 9.62821  ? 81  ASN   B C   1 
ATOM   3504 O O   . ASN   B 1 102 ? -16.02900 5.72432   30.66342  1.000 7.34571  ? 81  ASN   B O   1 
ATOM   3505 C CB  . ASN   B 1 102 ? -16.53708 2.65921   31.91727  1.000 11.32146 ? 81  ASN   B CB  1 
ATOM   3506 C CG  . ASN   B 1 102 ? -17.70759 1.69273   31.93534  1.000 14.32372 ? 81  ASN   B CG  1 
ATOM   3507 O OD1 . ASN   B 1 102 ? -18.51275 1.65768   31.00586  1.000 17.96523 ? 81  ASN   B OD1 1 
ATOM   3508 N ND2 . ASN   B 1 102 ? -17.81283 0.90922   33.00359  1.000 16.10166 ? 81  ASN   B ND2 1 
ATOM   3509 N N   . LEU   B 1 103 ? -14.19368 4.43560   30.85343  1.000 7.23149  ? 82  LEU   B N   1 
ATOM   3510 C CA  . LEU   B 1 103 ? -13.31924 5.59734   30.98079  1.000 9.70958  ? 82  LEU   B CA  1 
ATOM   3511 C C   . LEU   B 1 103 ? -13.30319 6.42530   29.70279  1.000 6.56776  ? 82  LEU   B C   1 
ATOM   3512 O O   . LEU   B 1 103 ? -13.35153 7.66052   29.75777  1.000 5.30120  ? 82  LEU   B O   1 
ATOM   3513 C CB  . LEU   B 1 103 ? -11.90412 5.15853   31.35306  1.000 6.80294  ? 82  LEU   B CB  1 
ATOM   3514 C CG  . LEU   B 1 103 ? -11.76791 4.49411   32.72508  1.000 9.39874  ? 82  LEU   B CG  1 
ATOM   3515 C CD1 . LEU   B 1 103 ? -10.40162 3.84973   32.87328  1.000 8.32620  ? 82  LEU   B CD1 1 
ATOM   3516 C CD2 . LEU   B 1 103 ? -12.01812 5.50201   33.83597  1.000 6.64828  ? 82  LEU   B CD2 1 
ATOM   3517 N N   . ALA   B 1 104 ? -13.23772 5.76603   28.54311  1.000 7.78094  ? 83  ALA   B N   1 
ATOM   3518 C CA  . ALA   B 1 104 ? -13.23030 6.50009   27.28293  1.000 5.96298  ? 83  ALA   B CA  1 
ATOM   3519 C C   . ALA   B 1 104 ? -14.52632 7.27580   27.08827  1.000 5.25153  ? 83  ALA   B C   1 
ATOM   3520 O O   . ALA   B 1 104 ? -14.50624 8.42902   26.64297  1.000 9.36700  ? 83  ALA   B O   1 
ATOM   3521 C CB  . ALA   B 1 104 ? -12.99665 5.54076   26.11373  1.000 3.99192  ? 83  ALA   B CB  1 
ATOM   3522 N N   . GLU   B 1 105 ? -15.66642 6.66001   27.41334  1.000 6.97381  ? 84  GLU   B N   1 
ATOM   3523 C CA  . GLU   B 1 105 ? -16.93992 7.35939   27.27201  1.000 10.10678 ? 84  GLU   B CA  1 
ATOM   3524 C C   . GLU   B 1 105 ? -16.99301 8.58051   28.17799  1.000 10.02685 ? 84  GLU   B C   1 
ATOM   3525 O O   . GLU   B 1 105 ? -17.43553 9.65692   27.75993  1.000 12.91904 ? 84  GLU   B O   1 
ATOM   3526 C CB  . GLU   B 1 105 ? -18.09935 6.41297   27.58385  1.000 11.58314 ? 84  GLU   B CB  1 
ATOM   3527 C CG  . GLU   B 1 105 ? -19.48225 7.02570   27.38905  1.000 14.74096 ? 84  GLU   B CG  1 
ATOM   3528 C CD  . GLU   B 1 105 ? -20.56177 6.26888   28.14273  1.000 16.46658 ? 84  GLU   B CD  1 
ATOM   3529 O OE1 . GLU   B 1 105 ? -20.22872 5.25631   28.79734  1.000 14.96986 ? 84  GLU   B OE1 1 
ATOM   3530 O OE2 . GLU   B 1 105 ? -21.74172 6.67884   28.07471  1.000 18.69249 ? 84  GLU   B OE2 1 
ATOM   3531 N N   . THR   B 1 106 ? -16.53824 8.43158   29.42319  1.000 9.30192  ? 85  THR   B N   1 
ATOM   3532 C CA  . THR   B 1 106 ? -16.53832 9.55237   30.35652  1.000 11.33641 ? 85  THR   B CA  1 
ATOM   3533 C C   . THR   B 1 106 ? -15.64723 10.68270  29.85539  1.000 7.94523  ? 85  THR   B C   1 
ATOM   3534 O O   . THR   B 1 106 ? -16.04043 11.85464  29.87261  1.000 9.54936  ? 85  THR   B O   1 
ATOM   3535 C CB  . THR   B 1 106 ? -16.08263 9.07104   31.73417  1.000 12.05210 ? 85  THR   B CB  1 
ATOM   3536 O OG1 . THR   B 1 106 ? -17.05255 8.15622   32.26086  1.000 9.23278  ? 85  THR   B OG1 1 
ATOM   3537 C CG2 . THR   B 1 106 ? -15.90919 10.24171  32.69135  1.000 7.28755  ? 85  THR   B CG2 1 
ATOM   3538 N N   . ALA   B 1 107 ? -14.44302 10.34559  29.38752  1.000 9.57635  ? 86  ALA   B N   1 
ATOM   3539 C CA  . ALA   B 1 107 ? -13.52476 11.37472  28.91333  1.000 7.79467  ? 86  ALA   B CA  1 
ATOM   3540 C C   . ALA   B 1 107 ? -14.08801 12.09975  27.69731  1.000 7.82541  ? 86  ALA   B C   1 
ATOM   3541 O O   . ALA   B 1 107 ? -14.00254 13.33000  27.60315  1.000 8.40228  ? 86  ALA   B O   1 
ATOM   3542 C CB  . ALA   B 1 107 ? -12.16446 10.75327  28.59288  1.000 6.43630  ? 86  ALA   B CB  1 
ATOM   3543 N N   . ILE   B 1 108 ? -14.67279 11.35385  26.75853  1.000 5.86947  ? 87  ILE   B N   1 
ATOM   3544 C CA  . ILE   B 1 108 ? -15.20817 11.96368  25.54481  1.000 6.38567  ? 87  ILE   B CA  1 
ATOM   3545 C C   . ILE   B 1 108 ? -16.41571 12.83555  25.86826  1.000 8.33799  ? 87  ILE   B C   1 
ATOM   3546 O O   . ILE   B 1 108 ? -16.55960 13.94412  25.33721  1.000 6.95020  ? 87  ILE   B O   1 
ATOM   3547 C CB  . ILE   B 1 108 ? -15.55140 10.87271  24.51477  1.000 7.71204  ? 87  ILE   B CB  1 
ATOM   3548 C CG1 . ILE   B 1 108 ? -14.26944 10.24942  23.95776  1.000 8.78401  ? 87  ILE   B CG1 1 
ATOM   3549 C CG2 . ILE   B 1 108 ? -16.39781 11.44391  23.38960  1.000 7.49811  ? 87  ILE   B CG2 1 
ATOM   3550 C CD1 . ILE   B 1 108 ? -14.48916 8.93263   23.24404  1.000 10.57692 ? 87  ILE   B CD1 1 
ATOM   3551 N N   . THR   B 1 109 ? -17.30190 12.35194  26.74091  1.000 8.22575  ? 88  THR   B N   1 
ATOM   3552 C CA  . THR   B 1 109 ? -18.48461 13.12851  27.09748  1.000 7.78663  ? 88  THR   B CA  1 
ATOM   3553 C C   . THR   B 1 109 ? -18.09952 14.42208  27.80869  1.000 10.96037 ? 88  THR   B C   1 
ATOM   3554 O O   . THR   B 1 109 ? -18.65898 15.48762  27.52278  1.000 10.30063 ? 88  THR   B O   1 
ATOM   3555 C CB  . THR   B 1 109 ? -19.42042 12.28241  27.96221  1.000 17.35877 ? 88  THR   B CB  1 
ATOM   3556 O OG1 . THR   B 1 109 ? -20.01357 11.25613  27.15511  1.000 15.04074 ? 88  THR   B OG1 1 
ATOM   3557 C CG2 . THR   B 1 109 ? -20.52074 13.14158  28.55921  1.000 15.53190 ? 88  THR   B CG2 1 
ATOM   3558 N N   . LYS   B 1 110 ? -17.13087 14.35403  28.72549  1.000 11.28392 ? 89  LYS   B N   1 
ATOM   3559 C CA  . LYS   B 1 110 ? -16.65388 15.56898  29.37932  1.000 10.69368 ? 89  LYS   B CA  1 
ATOM   3560 C C   . LYS   B 1 110 ? -16.04519 16.52843  28.36713  1.000 11.27288 ? 89  LYS   B C   1 
ATOM   3561 O O   . LYS   B 1 110 ? -16.24632 17.74547  28.45232  1.000 8.55947  ? 89  LYS   B O   1 
ATOM   3562 C CB  . LYS   B 1 110 ? -15.63169 15.21959  30.46001  1.000 10.73919 ? 89  LYS   B CB  1 
ATOM   3563 C CG  . LYS   B 1 110 ? -16.23193 14.58197  31.69474  1.000 12.97023 ? 89  LYS   B CG  1 
ATOM   3564 C CD  . LYS   B 1 110 ? -15.18279 13.80305  32.46988  1.000 18.69196 ? 89  LYS   B CD  1 
ATOM   3565 C CE  . LYS   B 1 110 ? -13.99314 14.67663  32.81632  1.000 17.16589 ? 89  LYS   B CE  1 
ATOM   3566 N NZ  . LYS   B 1 110 ? -13.28737 14.17719  34.03112  1.000 15.58325 ? 89  LYS   B NZ  1 
ATOM   3567 N N   . LEU   B 1 111 ? -15.29051 15.99232  27.40562  1.000 7.57124  ? 90  LEU   B N   1 
ATOM   3568 C CA  . LEU   B 1 111 ? -14.66827 16.82284  26.38183  1.000 7.14309  ? 90  LEU   B CA  1 
ATOM   3569 C C   . LEU   B 1 111 ? -15.71402 17.52303  25.52196  1.000 9.64514  ? 90  LEU   B C   1 
ATOM   3570 O O   . LEU   B 1 111 ? -15.60115 18.72410  25.25154  1.000 8.89476  ? 90  LEU   B O   1 
ATOM   3571 C CB  . LEU   B 1 111 ? -13.74273 15.96057  25.52204  1.000 5.95480  ? 90  LEU   B CB  1 
ATOM   3572 C CG  . LEU   B 1 111 ? -12.97228 16.61741  24.37598  1.000 7.61870  ? 90  LEU   B CG  1 
ATOM   3573 C CD1 . LEU   B 1 111 ? -12.06999 17.72733  24.88745  1.000 8.91919  ? 90  LEU   B CD1 1 
ATOM   3574 C CD2 . LEU   B 1 111 ? -12.16167 15.56805  23.62748  1.000 9.44392  ? 90  LEU   B CD2 1 
ATOM   3575 N N   . LEU   B 1 112 ? -16.74475 16.79006  25.09026  1.000 9.70083  ? 91  LEU   B N   1 
ATOM   3576 C CA  . LEU   B 1 112 ? -17.77586 17.38780  24.24804  1.000 8.41250  ? 91  LEU   B CA  1 
ATOM   3577 C C   . LEU   B 1 112 ? -18.59939 18.40926  25.02183  1.000 11.54703 ? 91  LEU   B C   1 
ATOM   3578 O O   . LEU   B 1 112 ? -18.97152 19.45537  24.47650  1.000 11.47980 ? 91  LEU   B O   1 
ATOM   3579 C CB  . LEU   B 1 112 ? -18.67717 16.29743  23.66880  1.000 11.63723 ? 91  LEU   B CB  1 
ATOM   3580 C CG  . LEU   B 1 112 ? -18.04330 15.36361  22.63591  1.000 12.04913 ? 91  LEU   B CG  1 
ATOM   3581 C CD1 . LEU   B 1 112 ? -18.89847 14.11753  22.45643  1.000 17.67038 ? 91  LEU   B CD1 1 
ATOM   3582 C CD2 . LEU   B 1 112 ? -17.85940 16.08048  21.30889  1.000 12.66475 ? 91  LEU   B CD2 1 
ATOM   3583 N N   . GLU   B 1 113 ? -18.90158 18.11963  26.29089  1.000 10.55880 ? 92  GLU   B N   1 
ATOM   3584 C CA  . GLU   B 1 113 ? -19.67639 19.05668  27.09732  1.000 10.01902 ? 92  GLU   B CA  1 
ATOM   3585 C C   . GLU   B 1 113 ? -18.91563 20.35516  27.32450  1.000 12.62220 ? 92  GLU   B C   1 
ATOM   3586 O O   . GLU   B 1 113 ? -19.49001 21.44368  27.21016  1.000 10.27749 ? 92  GLU   B O   1 
ATOM   3587 C CB  . GLU   B 1 113 ? -20.05647 18.41651  28.43400  1.000 16.55725 ? 92  GLU   B CB  1 
ATOM   3588 C CG  . GLU   B 1 113 ? -21.24707 17.47691  28.35240  1.000 25.36558 ? 92  GLU   B CG  1 
ATOM   3589 C CD  . GLU   B 1 113 ? -21.54060 16.77131  29.66610  1.000 35.62682 ? 92  GLU   B CD  1 
ATOM   3590 O OE1 . GLU   B 1 113 ? -20.73545 16.90167  30.61386  1.000 33.14126 ? 92  GLU   B OE1 1 
ATOM   3591 O OE2 . GLU   B 1 113 ? -22.58612 16.08920  29.75101  1.000 29.69652 ? 92  GLU   B OE2 1 
ATOM   3592 N N   . LYS   B 1 114 ? -17.61922 20.26620  27.63225  1.000 12.43705 ? 93  LYS   B N   1 
ATOM   3593 C CA  . LYS   B 1 114 ? -16.87428 21.47550  27.96198  1.000 10.14663 ? 93  LYS   B CA  1 
ATOM   3594 C C   . LYS   B 1 114 ? -16.65525 22.35732  26.73870  1.000 15.74549 ? 93  LYS   B C   1 
ATOM   3595 O O   . LYS   B 1 114 ? -16.49276 23.57410  26.88105  1.000 14.98065 ? 93  LYS   B O   1 
ATOM   3596 C CB  . LYS   B 1 114 ? -15.54097 21.11834  28.62003  1.000 12.21846 ? 93  LYS   B CB  1 
ATOM   3597 C CG  . LYS   B 1 114 ? -14.45691 20.68092  27.65977  1.000 10.43236 ? 93  LYS   B CG  1 
ATOM   3598 C CD  . LYS   B 1 114 ? -13.31485 19.97759  28.38851  1.000 13.40060 ? 93  LYS   B CD  1 
ATOM   3599 C CE  . LYS   B 1 114 ? -12.52244 20.95516  29.24342  1.000 17.32556 ? 93  LYS   B CE  1 
ATOM   3600 N NZ  . LYS   B 1 114 ? -11.47267 20.27815  30.05647  1.000 16.04920 ? 93  LYS   B NZ  1 
ATOM   3601 N N   . THR   B 1 115 ? -16.65153 21.77400  25.53749  1.000 14.80376 ? 94  THR   B N   1 
ATOM   3602 C CA  . THR   B 1 115 ? -16.49432 22.53787  24.30631  1.000 16.28541 ? 94  THR   B CA  1 
ATOM   3603 C C   . THR   B 1 115 ? -17.81619 22.84530  23.62087  1.000 12.39177 ? 94  THR   B C   1 
ATOM   3604 O O   . THR   B 1 115 ? -17.81511 23.54965  22.60502  1.000 11.80377 ? 94  THR   B O   1 
ATOM   3605 C CB  . THR   B 1 115 ? -15.59638 21.79053  23.31465  1.000 14.45565 ? 94  THR   B CB  1 
ATOM   3606 O OG1 . THR   B 1 115 ? -16.11291 20.47191  23.09878  1.000 12.21333 ? 94  THR   B OG1 1 
ATOM   3607 C CG2 . THR   B 1 115 ? -14.18939 21.68668  23.85985  1.000 12.44475 ? 94  THR   B CG2 1 
ATOM   3608 N N   . ASN   B 1 116 ? -18.92921 22.33181  24.14430  1.000 14.99681 ? 95  ASN   B N   1 
ATOM   3609 C CA  . ASN   B 1 116 ? -20.25017 22.50974  23.54424  1.000 17.57889 ? 95  ASN   B CA  1 
ATOM   3610 C C   . ASN   B 1 116 ? -20.24331 22.07315  22.07843  1.000 17.46012 ? 95  ASN   B C   1 
ATOM   3611 O O   . ASN   B 1 116 ? -20.73823 22.76790  21.18845  1.000 24.62822 ? 95  ASN   B O   1 
ATOM   3612 C CB  . ASN   B 1 116 ? -20.72783 23.95653  23.69378  1.000 17.59452 ? 95  ASN   B CB  1 
ATOM   3613 C CG  . ASN   B 1 116 ? -22.19873 24.12498  23.35485  1.000 29.64918 ? 95  ASN   B CG  1 
ATOM   3614 O OD1 . ASN   B 1 116 ? -22.98305 23.18044  23.45512  1.000 24.85355 ? 95  ASN   B OD1 1 
ATOM   3615 N ND2 . ASN   B 1 116 ? -22.57731 25.33036  22.94363  1.000 36.43373 ? 95  ASN   B ND2 1 
ATOM   3616 N N   . VAL   B 1 117 ? -19.65760 20.90358  21.83031  1.000 14.04732 ? 96  VAL   B N   1 
ATOM   3617 C CA  . VAL   B 1 117 ? -19.57095 20.32005  20.49560  1.000 14.27108 ? 96  VAL   B CA  1 
ATOM   3618 C C   . VAL   B 1 117 ? -20.47370 19.09689  20.44966  1.000 13.98727 ? 96  VAL   B C   1 
ATOM   3619 O O   . VAL   B 1 117 ? -20.40825 18.23462  21.33418  1.000 14.80404 ? 96  VAL   B O   1 
ATOM   3620 C CB  . VAL   B 1 117 ? -18.12203 19.95197  20.12963  1.000 15.20415 ? 96  VAL   B CB  1 
ATOM   3621 C CG1 . VAL   B 1 117 ? -18.07667 19.20885  18.79857  1.000 13.33318 ? 96  VAL   B CG1 1 
ATOM   3622 C CG2 . VAL   B 1 117 ? -17.26220 21.20363  20.06688  1.000 17.48321 ? 96  VAL   B CG2 1 
ATOM   3623 N N   . GLN   B 1 118 ? -21.32906 19.03648  19.43676  1.000 11.27985 ? 97  GLN   B N   1 
ATOM   3624 C CA  . GLN   B 1 118 ? -22.21145 17.89518  19.25104  1.000 12.82235 ? 97  GLN   B CA  1 
ATOM   3625 C C   . GLN   B 1 118 ? -21.43020 16.71897  18.66792  1.000 11.03311 ? 97  GLN   B C   1 
ATOM   3626 O O   . GLN   B 1 118 ? -20.56520 16.91523  17.81062  1.000 12.84278 ? 97  GLN   B O   1 
ATOM   3627 C CB  . GLN   B 1 118 ? -23.36925 18.25883  18.32353  1.000 20.22188 ? 97  GLN   B CB  1 
ATOM   3628 C CG  . GLN   B 1 118 ? -24.30622 19.31035  18.88994  1.000 16.19093 ? 97  GLN   B CG  1 
ATOM   3629 C CD  . GLN   B 1 118 ? -24.98792 18.84791  20.15793  1.000 17.35843 ? 97  GLN   B CD  1 
ATOM   3630 O OE1 . GLN   B 1 118 ? -24.90339 19.50072  21.19766  1.000 25.00076 ? 97  GLN   B OE1 1 
ATOM   3631 N NE2 . GLN   B 1 118 ? -25.65612 17.70858  20.08369  1.000 16.89855 ? 97  GLN   B NE2 1 
ATOM   3632 N N   . PRO   B 1 119 ? -21.70564 15.49334  19.12078  1.000 12.27024 ? 98  PRO   B N   1 
ATOM   3633 C CA  . PRO   B 1 119 ? -20.99198 14.33304  18.55874  1.000 13.05897 ? 98  PRO   B CA  1 
ATOM   3634 C C   . PRO   B 1 119 ? -21.15649 14.19351  17.05566  1.000 9.56505  ? 98  PRO   B C   1 
ATOM   3635 O O   . PRO   B 1 119 ? -20.21970 13.75004  16.37981  1.000 11.13508 ? 98  PRO   B O   1 
ATOM   3636 C CB  . PRO   B 1 119 ? -21.60145 13.13374  19.30498  1.000 12.76582 ? 98  PRO   B CB  1 
ATOM   3637 C CG  . PRO   B 1 119 ? -22.63867 13.68528  20.23362  1.000 15.81165 ? 98  PRO   B CG  1 
ATOM   3638 C CD  . PRO   B 1 119 ? -22.43784 15.16000  20.35123  1.000 11.82868 ? 98  PRO   B CD  1 
ATOM   3639 N N   . GLN   B 1 120 ? -22.31290 14.57356  16.50464  1.000 13.78560 ? 99  GLN   B N   1 
ATOM   3640 C CA  . GLN   B 1 120 ? -22.51206 14.47128  15.06388  1.000 14.98940 ? 99  GLN   B CA  1 
ATOM   3641 C C   . GLN   B 1 120 ? -21.60747 15.42184  14.28786  1.000 11.54917 ? 99  GLN   B C   1 
ATOM   3642 O O   . GLN   B 1 120 ? -21.44827 15.25527  13.07487  1.000 14.69212 ? 99  GLN   B O   1 
ATOM   3643 C CB  . GLN   B 1 120 ? -23.97472 14.74883  14.70736  1.000 12.81243 ? 99  GLN   B CB  1 
ATOM   3644 C CG  . GLN   B 1 120 ? -24.53052 16.03837  15.28678  1.000 19.78620 ? 99  GLN   B CG  1 
ATOM   3645 C CD  . GLN   B 1 120 ? -26.00480 16.22620  14.97871  1.000 33.19492 ? 99  GLN   B CD  1 
ATOM   3646 O OE1 . GLN   B 1 120 ? -26.85761 16.08359  15.85553  1.000 40.12855 ? 99  GLN   B OE1 1 
ATOM   3647 N NE2 . GLN   B 1 120 ? -26.31210 16.54209  13.72554  1.000 25.30887 ? 99  GLN   B NE2 1 
ATOM   3648 N N   . ASP   B 1 121 ? -21.01554 16.40931  14.95439  1.000 12.23160 ? 100 ASP   B N   1 
ATOM   3649 C CA  . ASP   B 1 121 ? -20.10614 17.35165  14.31824  1.000 11.51014 ? 100 ASP   B CA  1 
ATOM   3650 C C   . ASP   B 1 121 ? -18.64213 16.93908  14.44988  1.000 11.51438 ? 100 ASP   B C   1 
ATOM   3651 O O   . ASP   B 1 121 ? -17.75163 17.71483  14.08321  1.000 14.79159 ? 100 ASP   B O   1 
ATOM   3652 C CB  . ASP   B 1 121 ? -20.32228 18.75371  14.89240  1.000 12.31124 ? 100 ASP   B CB  1 
ATOM   3653 C CG  . ASP   B 1 121 ? -21.69459 19.30854  14.55681  1.000 25.06235 ? 100 ASP   B CG  1 
ATOM   3654 O OD1 . ASP   B 1 121 ? -22.13477 19.13608  13.40004  1.000 17.43792 ? 100 ASP   B OD1 1 
ATOM   3655 O OD2 . ASP   B 1 121 ? -22.33628 19.90806  15.44498  1.000 16.77631 ? 100 ASP   B OD2 1 
ATOM   3656 N N   . ILE   B 1 122 ? -18.37522 15.74702  14.97205  1.000 10.86361 ? 101 ILE   B N   1 
ATOM   3657 C CA  . ILE   B 1 122 ? -17.03423 15.17648  14.97308  1.000 10.95658 ? 101 ILE   B CA  1 
ATOM   3658 C C   . ILE   B 1 122 ? -16.87198 14.33745  13.71373  1.000 11.09746 ? 101 ILE   B C   1 
ATOM   3659 O O   . ILE   B 1 122 ? -17.71751 13.48796  13.40956  1.000 11.48409 ? 101 ILE   B O   1 
ATOM   3660 C CB  . ILE   B 1 122 ? -16.79465 14.33308  16.23510  1.000 9.50021  ? 101 ILE   B CB  1 
ATOM   3661 C CG1 . ILE   B 1 122 ? -16.94842 15.19842  17.48893  1.000 8.88982  ? 101 ILE   B CG1 1 
ATOM   3662 C CG2 . ILE   B 1 122 ? -15.42651 13.66405  16.17900  1.000 9.51077  ? 101 ILE   B CG2 1 
ATOM   3663 C CD1 . ILE   B 1 122 ? -15.93599 16.31490  17.58773  1.000 9.57848  ? 101 ILE   B CD1 1 
ATOM   3664 N N   . SER   B 1 123 ? -15.79555 14.58236  12.96918  1.000 12.71167 ? 102 SER   B N   1 
ATOM   3665 C CA  . SER   B 1 123 ? -15.57146 13.85635  11.72552  1.000 12.67830 ? 102 SER   B CA  1 
ATOM   3666 C C   . SER   B 1 123 ? -14.73551 12.59992  11.91303  1.000 12.71600 ? 102 SER   B C   1 
ATOM   3667 O O   . SER   B 1 123 ? -14.94052 11.61534  11.19174  1.000 7.80028  ? 102 SER   B O   1 
ATOM   3668 C CB  . SER   B 1 123 ? -14.89307 14.76330  10.69550  1.000 12.14787 ? 102 SER   B CB  1 
ATOM   3669 O OG  . SER   B 1 123 ? -15.71796 15.86452  10.35624  1.000 15.33044 ? 102 SER   B OG  1 
ATOM   3670 N N   . LEU   B 1 124 ? -13.79932 12.61112  12.85785  1.000 7.01094  ? 103 LEU   B N   1 
ATOM   3671 C CA  . LEU   B 1 124 ? -12.87416 11.50377  13.04408  1.000 6.02572  ? 103 LEU   B CA  1 
ATOM   3672 C C   . LEU   B 1 124 ? -12.71799 11.19999  14.52434  1.000 7.09659  ? 103 LEU   B C   1 
ATOM   3673 O O   . LEU   B 1 124 ? -12.52535 12.11395  15.33046  1.000 8.34536  ? 103 LEU   B O   1 
ATOM   3674 C CB  . LEU   B 1 124 ? -11.50828 11.82237  12.42593  1.000 8.82906  ? 103 LEU   B CB  1 
ATOM   3675 C CG  . LEU   B 1 124 ? -10.38237 10.84061  12.74109  1.000 6.34090  ? 103 LEU   B CG  1 
ATOM   3676 C CD1 . LEU   B 1 124 ? -10.43237 9.66806   11.78395  1.000 8.04701  ? 103 LEU   B CD1 1 
ATOM   3677 C CD2 . LEU   B 1 124 ? -9.04321  11.55291  12.65088  1.000 8.20718  ? 103 LEU   B CD2 1 
ATOM   3678 N N   . LEU   B 1 125 ? -12.79167 9.91701   14.87328  1.000 5.33307  ? 104 LEU   B N   1 
ATOM   3679 C CA  . LEU   B 1 125 ? -12.54915 9.44538   16.23360  1.000 6.81523  ? 104 LEU   B CA  1 
ATOM   3680 C C   . LEU   B 1 125 ? -11.35988 8.49450   16.19829  1.000 7.20487  ? 104 LEU   B C   1 
ATOM   3681 O O   . LEU   B 1 125 ? -11.46510 7.37968   15.67492  1.000 5.80967  ? 104 LEU   B O   1 
ATOM   3682 C CB  . LEU   B 1 125 ? -13.78499 8.75912   16.81298  1.000 6.19509  ? 104 LEU   B CB  1 
ATOM   3683 C CG  . LEU   B 1 125 ? -13.62281 8.25756   18.24880  1.000 6.68809  ? 104 LEU   B CG  1 
ATOM   3684 C CD1 . LEU   B 1 125 ? -13.35343 9.42550   19.19033  1.000 2.00834  ? 104 LEU   B CD1 1 
ATOM   3685 C CD2 . LEU   B 1 125 ? -14.84175 7.46390   18.69278  1.000 4.50212  ? 104 LEU   B CD2 1 
ATOM   3686 N N   . ALA   B 1 126 ? -10.23534 8.93515   16.75197  1.000 8.27862  ? 105 ALA   B N   1 
ATOM   3687 C CA  . ALA   B 1 126 ? -9.00531  8.15728   16.77151  1.000 9.25712  ? 105 ALA   B CA  1 
ATOM   3688 C C   . ALA   B 1 126 ? -8.78647  7.58037   18.16200  1.000 6.15061  ? 105 ALA   B C   1 
ATOM   3689 O O   . ALA   B 1 126 ? -9.06370  8.24133   19.16668  1.000 7.90623  ? 105 ALA   B O   1 
ATOM   3690 C CB  . ALA   B 1 126 ? -7.80862  9.02066   16.36754  1.000 5.25723  ? 105 ALA   B CB  1 
ATOM   3691 N N   . SER   B 1 127 ? -8.29054  6.34503   18.21877  1.000 5.66474  ? 106 SER   B N   1 
ATOM   3692 C CA  . SER   B 1 127 ? -8.10032  5.65508   19.48642  1.000 6.26515  ? 106 SER   B CA  1 
ATOM   3693 C C   . SER   B 1 127 ? -6.73729  4.98173   19.53928  1.000 7.48184  ? 106 SER   B C   1 
ATOM   3694 O O   . SER   B 1 127 ? -6.23016  4.48389   18.53043  1.000 8.47308  ? 106 SER   B O   1 
ATOM   3695 C CB  . SER   B 1 127 ? -9.18439  4.59718   19.71846  1.000 8.69291  ? 106 SER   B CB  1 
ATOM   3696 O OG  . SER   B 1 127 ? -9.06774  3.53035   18.79215  1.000 8.59404  ? 106 SER   B OG  1 
ATOM   3697 N N   . VAL   B 1 128 ? -6.14966  4.96018   20.73528  1.000 9.26516  ? 107 VAL   B N   1 
ATOM   3698 C CA  . VAL   B 1 128 ? -4.97916  4.13765   21.01592  1.000 7.97564  ? 107 VAL   B CA  1 
ATOM   3699 C C   . VAL   B 1 128 ? -5.20735  3.41342   22.33363  1.000 10.67849 ? 107 VAL   B C   1 
ATOM   3700 O O   . VAL   B 1 128 ? -5.53740  4.03791   23.34923  1.000 7.65097  ? 107 VAL   B O   1 
ATOM   3701 C CB  . VAL   B 1 128 ? -3.66833  4.95104   21.05344  1.000 15.61983 ? 107 VAL   B CB  1 
ATOM   3702 C CG1 . VAL   B 1 128 ? -3.31827  5.45607   19.67685  1.000 16.07736 ? 107 VAL   B CG1 1 
ATOM   3703 C CG2 . VAL   B 1 128 ? -3.78144  6.11295   22.00132  1.000 13.31721 ? 107 VAL   B CG2 1 
ATOM   3704 N N   . SER   B 1 129 ? -5.05902  2.09613   22.30772  1.000 8.59269  ? 108 SER   B N   1 
ATOM   3705 C CA  . SER   B 1 129 ? -5.18825  1.30276   23.51631  1.000 7.47341  ? 108 SER   B CA  1 
ATOM   3706 C C   . SER   B 1 129 ? -4.61948  -0.07505  23.24525  1.000 12.34580 ? 108 SER   B C   1 
ATOM   3707 O O   . SER   B 1 129 ? -4.65499  -0.57444  22.11512  1.000 11.56478 ? 108 SER   B O   1 
ATOM   3708 C CB  . SER   B 1 129 ? -6.64171  1.18890   23.98544  1.000 9.68180  ? 108 SER   B CB  1 
ATOM   3709 O OG  . SER   B 1 129 ? -6.73851  0.33442   25.11588  1.000 9.89614  ? 108 SER   B OG  1 
ATOM   3710 N N   . MET   B 1 130 ? -4.09051  -0.67166  24.30133  1.000 9.85545  ? 109 MET   B N   1 
ATOM   3711 C CA  . MET   B 1 130 ? -3.54333  -2.01211  24.26705  1.000 9.73162  ? 109 MET   B CA  1 
ATOM   3712 C C   . MET   B 1 130 ? -4.55784  -3.04881  24.72091  1.000 12.45561 ? 109 MET   B C   1 
ATOM   3713 O O   . MET   B 1 130 ? -4.29532  -4.25043  24.60845  1.000 15.90352 ? 109 MET   B O   1 
ATOM   3714 C CB  . MET   B 1 130 ? -2.29943  -2.03444  25.14818  1.000 9.84535  ? 109 MET   B CB  1 
ATOM   3715 C CG  . MET   B 1 130 ? -1.13533  -1.35550  24.46498  1.000 11.00426 ? 109 MET   B CG  1 
ATOM   3716 S SD  . MET   B 1 130 ? 0.41834   -1.78829  25.22359  1.000 14.22534 ? 109 MET   B SD  1 
ATOM   3717 C CE  . MET   B 1 130 ? 0.18723   -0.83362  26.71347  1.000 17.47587 ? 109 MET   B CE  1 
ATOM   3718 N N   . THR   B 1 131 ? -5.71042  -2.60529  25.20677  1.000 12.40863 ? 110 THR   B N   1 
ATOM   3719 C CA  . THR   B 1 131 ? -6.79547  -3.49727  25.57468  1.000 10.24044 ? 110 THR   B CA  1 
ATOM   3720 C C   . THR   B 1 131 ? -7.28897  -4.22515  24.33137  1.000 12.57501 ? 110 THR   B C   1 
ATOM   3721 O O   . THR   B 1 131 ? -7.70240  -3.56762  23.36337  1.000 11.78780 ? 110 THR   B O   1 
ATOM   3722 C CB  . THR   B 1 131 ? -7.93762  -2.70650  26.21132  1.000 13.30518 ? 110 THR   B CB  1 
ATOM   3723 O OG1 . THR   B 1 131 ? -7.49423  -2.12164  27.44368  1.000 16.56304 ? 110 THR   B OG1 1 
ATOM   3724 C CG2 . THR   B 1 131 ? -9.13856  -3.60469  26.47058  1.000 16.63972 ? 110 THR   B CG2 1 
ATOM   3725 N N   . PRO   B 1 132 ? -7.25969  -5.55655  24.30424  1.000 10.19747 ? 111 PRO   B N   1 
ATOM   3726 C CA  . PRO   B 1 132 ? -7.73467  -6.28144  23.11402  1.000 11.64817 ? 111 PRO   B CA  1 
ATOM   3727 C C   . PRO   B 1 132 ? -9.19244  -5.95425  22.83486  1.000 8.88538  ? 111 PRO   B C   1 
ATOM   3728 O O   . PRO   B 1 132 ? -10.05553 -6.09715  23.70249  1.000 11.54486 ? 111 PRO   B O   1 
ATOM   3729 C CB  . PRO   B 1 132 ? -7.53880  -7.75474  23.49240  1.000 11.26918 ? 111 PRO   B CB  1 
ATOM   3730 C CG  . PRO   B 1 132 ? -6.52023  -7.74358  24.59152  1.000 15.10571 ? 111 PRO   B CG  1 
ATOM   3731 C CD  . PRO   B 1 132 ? -6.71452  -6.45768  25.33398  1.000 11.27055 ? 111 PRO   B CD  1 
ATOM   3732 N N   . ALA   B 1 133 ? -9.46264  -5.49430  21.61041  1.000 14.76689 ? 112 ALA   B N   1 
ATOM   3733 C CA  . ALA   B 1 133 ? -10.81531 -5.07543  21.24476  1.000 12.27090 ? 112 ALA   B CA  1 
ATOM   3734 C C   . ALA   B 1 133 ? -10.97919 -5.22268  19.73436  1.000 12.02447 ? 112 ALA   B C   1 
ATOM   3735 O O   . ALA   B 1 133 ? -10.45221 -4.41121  18.96830  1.000 7.92824  ? 112 ALA   B O   1 
ATOM   3736 C CB  . ALA   B 1 133 ? -11.08853 -3.64820  21.69898  1.000 11.76361 ? 112 ALA   B CB  1 
ATOM   3737 N N   . ILE   B 1 134 ? -11.70526 -6.25757  19.32189  1.000 11.46701 ? 113 ILE   B N   1 
ATOM   3738 C CA  . ILE   B 1 134 ? -12.12873 -6.42664  17.93345  1.000 11.77921 ? 113 ILE   B CA  1 
ATOM   3739 C C   . ILE   B 1 134 ? -13.62508 -6.71744  17.94708  1.000 11.62235 ? 113 ILE   B C   1 
ATOM   3740 O O   . ILE   B 1 134 ? -14.02634 -7.84695  18.26148  1.000 11.89928 ? 113 ILE   B O   1 
ATOM   3741 C CB  . ILE   B 1 134 ? -11.34525 -7.54371  17.22633  1.000 12.90836 ? 113 ILE   B CB  1 
ATOM   3742 C CG1 . ILE   B 1 134 ? -9.84806  -7.22679  17.20528  1.000 9.23803  ? 113 ILE   B CG1 1 
ATOM   3743 C CG2 . ILE   B 1 134 ? -11.84909 -7.72790  15.79963  1.000 10.84680 ? 113 ILE   B CG2 1 
ATOM   3744 C CD1 . ILE   B 1 134 ? -8.97712  -8.43596  16.94857  1.000 11.77493 ? 113 ILE   B CD1 1 
ATOM   3745 N N   . PRO   B 1 135 ? -14.49150 -5.74799  17.60390  1.000 11.49424 ? 114 PRO   B N   1 
ATOM   3746 C CA  . PRO   B 1 135 ? -14.17667 -4.41439  17.06973  1.000 7.91087  ? 114 PRO   B CA  1 
ATOM   3747 C C   . PRO   B 1 135 ? -13.51536 -3.47027  18.07563  1.000 10.49782 ? 114 PRO   B C   1 
ATOM   3748 O O   . PRO   B 1 135 ? -13.61236 -3.68036  19.28333  1.000 6.49677  ? 114 PRO   B O   1 
ATOM   3749 C CB  . PRO   B 1 135 ? -15.55047 -3.87129  16.66611  1.000 7.08432  ? 114 PRO   B CB  1 
ATOM   3750 C CG  . PRO   B 1 135 ? -16.49895 -4.57095  17.57173  1.000 10.50846 ? 114 PRO   B CG  1 
ATOM   3751 C CD  . PRO   B 1 135 ? -15.94551 -5.95464  17.72811  1.000 11.65625 ? 114 PRO   B CD  1 
ATOM   3752 N N   . SER   B 1 136 ? -12.86246 -2.43252  17.55597  1.000 7.68582  ? 115 SER   B N   1 
ATOM   3753 C CA  . SER   B 1 136 ? -12.09810 -1.50222  18.36997  1.000 9.48578  ? 115 SER   B CA  1 
ATOM   3754 C C   . SER   B 1 136 ? -12.99940 -0.75050  19.35266  1.000 9.73441  ? 115 SER   B C   1 
ATOM   3755 O O   . SER   B 1 136 ? -14.22812 -0.74388  19.24471  1.000 9.75253  ? 115 SER   B O   1 
ATOM   3756 C CB  . SER   B 1 136 ? -11.35650 -0.51399  17.47435  1.000 12.21339 ? 115 SER   B CB  1 
ATOM   3757 O OG  . SER   B 1 136 ? -12.26988 0.26489   16.72007  1.000 13.37476 ? 115 SER   B OG  1 
ATOM   3758 N N   . LEU   B 1 137 ? -12.35296 -0.10374  20.32783  1.000 9.53465  ? 116 LEU   B N   1 
ATOM   3759 C CA  . LEU   B 1 137 ? -13.08528 0.65109   21.34251  1.000 11.35432 ? 116 LEU   B CA  1 
ATOM   3760 C C   . LEU   B 1 137 ? -13.89242 1.78236   20.71883  1.000 7.85731  ? 116 LEU   B C   1 
ATOM   3761 O O   . LEU   B 1 137 ? -15.03835 2.03062   21.11533  1.000 7.97468  ? 116 LEU   B O   1 
ATOM   3762 C CB  . LEU   B 1 137 ? -12.11208 1.20779   22.38144  1.000 7.52304  ? 116 LEU   B CB  1 
ATOM   3763 C CG  . LEU   B 1 137 ? -11.35683 0.20392   23.24982  1.000 12.81161 ? 116 LEU   B CG  1 
ATOM   3764 C CD1 . LEU   B 1 137 ? -10.29489 0.91170   24.07309  1.000 12.53443 ? 116 LEU   B CD1 1 
ATOM   3765 C CD2 . LEU   B 1 137 ? -12.32653 -0.51624  24.15926  1.000 11.74510 ? 116 LEU   B CD2 1 
ATOM   3766 N N   . ASP   B 1 138 ? -13.30570 2.48054   19.74253  1.000 6.77868  ? 117 ASP   B N   1 
ATOM   3767 C CA  . ASP   B 1 138 ? -13.98808 3.59428   19.09220  1.000 7.78218  ? 117 ASP   B CA  1 
ATOM   3768 C C   . ASP   B 1 138 ? -15.25450 3.14441   18.37445  1.000 10.08051 ? 117 ASP   B C   1 
ATOM   3769 O O   . ASP   B 1 138 ? -16.23506 3.89599   18.31470  1.000 8.30608  ? 117 ASP   B O   1 
ATOM   3770 C CB  . ASP   B 1 138 ? -13.02878 4.28044   18.12040  1.000 5.66261  ? 117 ASP   B CB  1 
ATOM   3771 C CG  . ASP   B 1 138 ? -12.24116 3.28888   17.28513  1.000 11.08052 ? 117 ASP   B CG  1 
ATOM   3772 O OD1 . ASP   B 1 138 ? -11.19877 2.80033   17.76454  1.000 8.81922  ? 117 ASP   B OD1 1 
ATOM   3773 O OD2 . ASP   B 1 138 ? -12.65591 3.00426   16.14578  1.000 6.54736  ? 117 ASP   B OD2 1 
ATOM   3774 N N   . GLY   B 1 139 ? -15.24999 1.93613   17.81156  1.000 10.22029 ? 118 GLY   B N   1 
ATOM   3775 C CA  . GLY   B 1 139 ? -16.46776 1.40750   17.22232  1.000 9.28645  ? 118 GLY   B CA  1 
ATOM   3776 C C   . GLY   B 1 139 ? -17.54206 1.12759   18.25656  1.000 6.98591  ? 118 GLY   B C   1 
ATOM   3777 O O   . GLY   B 1 139 ? -18.71829 1.42424   18.03737  1.000 8.21742  ? 118 GLY   B O   1 
ATOM   3778 N N   . ARG   B 1 140 ? -17.15357 0.55775   19.40080  1.000 9.52348  ? 119 ARG   B N   1 
ATOM   3779 C CA  . ARG   B 1 140 ? -18.12509 0.24850   20.44784  1.000 8.90698  ? 119 ARG   B CA  1 
ATOM   3780 C C   . ARG   B 1 140 ? -18.71729 1.51475   21.05776  1.000 8.02700  ? 119 ARG   B C   1 
ATOM   3781 O O   . ARG   B 1 140 ? -19.89792 1.54059   21.42129  1.000 8.40716  ? 119 ARG   B O   1 
ATOM   3782 C CB  . ARG   B 1 140 ? -17.47103 -0.61265  21.52924  1.000 9.16142  ? 119 ARG   B CB  1 
ATOM   3783 C CG  . ARG   B 1 140 ? -16.87685 -1.90630  21.00440  1.000 12.30176 ? 119 ARG   B CG  1 
ATOM   3784 C CD  . ARG   B 1 140 ? -16.28168 -2.74594  22.12204  1.000 11.59569 ? 119 ARG   B CD  1 
ATOM   3785 N NE  . ARG   B 1 140 ? -15.51740 -3.87180  21.59895  1.000 13.93853 ? 119 ARG   B NE  1 
ATOM   3786 C CZ  . ARG   B 1 140 ? -15.82828 -5.14567  21.79494  1.000 13.78066 ? 119 ARG   B CZ  1 
ATOM   3787 N NH1 . ARG   B 1 140 ? -16.88754 -5.49730  22.50515  1.000 17.51111 ? 119 ARG   B NH1 1 
ATOM   3788 N NH2 . ARG   B 1 140 ? -15.05893 -6.09045  21.26168  1.000 18.71979 ? 119 ARG   B NH2 1 
ATOM   3789 N N   . LEU   B 1 141 ? -17.91224 2.57287   21.18076  1.000 8.53663  ? 120 LEU   B N   1 
ATOM   3790 C CA  . LEU   B 1 141 ? -18.38802 3.82771   21.75089  1.000 7.57158  ? 120 LEU   B CA  1 
ATOM   3791 C C   . LEU   B 1 141 ? -19.46933 4.46304   20.89569  1.000 11.82880 ? 120 LEU   B C   1 
ATOM   3792 O O   . LEU   B 1 141 ? -20.22632 5.31157   21.38193  1.000 11.58223 ? 120 LEU   B O   1 
ATOM   3793 C CB  . LEU   B 1 141 ? -17.21495 4.79050   21.92044  1.000 8.57609  ? 120 LEU   B CB  1 
ATOM   3794 C CG  . LEU   B 1 141 ? -16.29976 4.46015   23.10412  1.000 13.71182 ? 120 LEU   B CG  1 
ATOM   3795 C CD1 . LEU   B 1 141 ? -14.99052 5.22737   23.01033  1.000 8.97690  ? 120 LEU   B CD1 1 
ATOM   3796 C CD2 . LEU   B 1 141 ? -17.00174 4.74819   24.42240  1.000 12.12891 ? 120 LEU   B CD2 1 
ATOM   3797 N N   . MET   B 1 142 ? -19.56000 4.05778   19.63333  1.000 10.79070 ? 121 MET   B N   1 
ATOM   3798 C CA  . MET   B 1 142 ? -20.54606 4.61023   18.72230  1.000 6.07576  ? 121 MET   B CA  1 
ATOM   3799 C C   . MET   B 1 142 ? -21.96359 4.22606   19.13985  1.000 7.97361  ? 121 MET   B C   1 
ATOM   3800 O O   . MET   B 1 142 ? -22.92555 4.89523   18.74580  1.000 7.54267  ? 121 MET   B O   1 
ATOM   3801 C CB  . MET   B 1 142 ? -20.18449 4.12173   17.32621  1.000 10.97297 ? 121 MET   B CB  1 
ATOM   3802 C CG  . MET   B 1 142 ? -19.39780 5.15046   16.53816  1.000 10.06797 ? 121 MET   B CG  1 
ATOM   3803 S SD  . MET   B 1 142 ? -18.88494 4.53349   14.92584  1.000 12.13308 ? 121 MET   B SD  1 
ATOM   3804 C CE  . MET   B 1 142 ? -20.21375 5.18358   13.91927  1.000 11.04035 ? 121 MET   B CE  1 
ATOM   3805 N N   . ASN   B 1 143 ? -22.10170 3.18494   19.96134  1.000 6.04196  ? 122 ASN   B N   1 
ATOM   3806 C CA  . ASN   B 1 143 ? -23.37824 2.77514   20.53304  1.000 8.75130  ? 122 ASN   B CA  1 
ATOM   3807 C C   . ASN   B 1 143 ? -23.69704 3.45608   21.86102  1.000 10.78407 ? 122 ASN   B C   1 
ATOM   3808 O O   . ASN   B 1 143 ? -24.80675 3.28234   22.37569  1.000 11.29007 ? 122 ASN   B O   1 
ATOM   3809 C CB  . ASN   B 1 143 ? -23.39635 1.25394   20.71686  1.000 4.74110  ? 122 ASN   B CB  1 
ATOM   3810 C CG  . ASN   B 1 143 ? -23.38996 0.51439   19.39489  1.000 10.29297 ? 122 ASN   B CG  1 
ATOM   3811 O OD1 . ASN   B 1 143 ? -24.05924 0.92005   18.44692  1.000 7.28264  ? 122 ASN   B OD1 1 
ATOM   3812 N ND2 . ASN   B 1 143 ? -22.61987 -0.56347  19.31787  1.000 7.19417  ? 122 ASN   B ND2 1 
ATOM   3813 N N   . ARG   B 1 144 ? -22.76509 4.22263   22.42662  1.000 12.67961 ? 123 ARG   B N   1 
ATOM   3814 C CA  . ARG   B 1 144 ? -23.01171 4.96993   23.65482  1.000 12.99821 ? 123 ARG   B CA  1 
ATOM   3815 C C   . ARG   B 1 144 ? -23.11292 6.47087   23.44687  1.000 11.54233 ? 123 ARG   B C   1 
ATOM   3816 O O   . ARG   B 1 144 ? -23.75788 7.15158   24.24703  1.000 11.56472 ? 123 ARG   B O   1 
ATOM   3817 C CB  . ARG   B 1 144 ? -21.90448 4.69494   24.67894  1.000 15.29790 ? 123 ARG   B CB  1 
ATOM   3818 C CG  . ARG   B 1 144 ? -21.84228 3.26235   25.16040  1.000 17.57238 ? 123 ARG   B CG  1 
ATOM   3819 C CD  . ARG   B 1 144 ? -20.62676 3.06589   26.03739  1.000 16.85369 ? 123 ARG   B CD  1 
ATOM   3820 N NE  . ARG   B 1 144 ? -20.48143 1.68916   26.48935  1.000 15.69113 ? 123 ARG   B NE  1 
ATOM   3821 C CZ  . ARG   B 1 144 ? -19.94069 1.34011   27.64788  1.000 13.07006 ? 123 ARG   B CZ  1 
ATOM   3822 N NH1 . ARG   B 1 144 ? -19.49062 2.24633   28.50004  1.000 16.77989 ? 123 ARG   B NH1 1 
ATOM   3823 N NH2 . ARG   B 1 144 ? -19.83928 0.05020   27.95380  1.000 14.78485 ? 123 ARG   B NH2 1 
ATOM   3824 N N   . ILE   B 1 145 ? -22.49527 7.00022   22.39753  1.000 13.66338 ? 124 ILE   B N   1 
ATOM   3825 C CA  . ILE   B 1 145 ? -22.47732 8.42828   22.11665  1.000 12.59003 ? 124 ILE   B CA  1 
ATOM   3826 C C   . ILE   B 1 145 ? -23.02216 8.62074   20.70949  1.000 13.62327 ? 124 ILE   B C   1 
ATOM   3827 O O   . ILE   B 1 145 ? -22.57696 7.93405   19.78821  1.000 7.65305  ? 124 ILE   B O   1 
ATOM   3828 C CB  . ILE   B 1 145 ? -21.06536 9.02866   22.23699  1.000 9.58802  ? 124 ILE   B CB  1 
ATOM   3829 C CG1 . ILE   B 1 145 ? -20.56414 8.88414   23.67426  1.000 15.70291 ? 124 ILE   B CG1 1 
ATOM   3830 C CG2 . ILE   B 1 145 ? -21.05429 10.49193  21.81848  1.000 9.71216  ? 124 ILE   B CG2 1 
ATOM   3831 C CD1 . ILE   B 1 145 ? -19.06347 8.98841   23.80952  1.000 15.40931 ? 124 ILE   B CD1 1 
ATOM   3832 N N   . PRO   B 1 146 ? -23.98756 9.51901   20.49710  1.000 15.93048 ? 125 PRO   B N   1 
ATOM   3833 C CA  . PRO   B 1 146 ? -24.64279 9.59452   19.18260  1.000 14.13513 ? 125 PRO   B CA  1 
ATOM   3834 C C   . PRO   B 1 146 ? -23.77882 10.20458  18.08767  1.000 11.29372 ? 125 PRO   B C   1 
ATOM   3835 O O   . PRO   B 1 146 ? -24.16298 11.20558  17.47188  1.000 11.89933 ? 125 PRO   B O   1 
ATOM   3836 C CB  . PRO   B 1 146 ? -25.88514 10.45310  19.46056  1.000 15.68287 ? 125 PRO   B CB  1 
ATOM   3837 C CG  . PRO   B 1 146 ? -25.52515 11.26730  20.65723  1.000 11.61210 ? 125 PRO   B CG  1 
ATOM   3838 C CD  . PRO   B 1 146 ? -24.60433 10.42188  21.48592  1.000 12.45477 ? 125 PRO   B CD  1 
ATOM   3839 N N   . PHE   B 1 147 ? -22.61874 9.60192   17.82672  1.000 8.21285  ? 126 PHE   B N   1 
ATOM   3840 C CA  . PHE   B 1 147 ? -21.87536 9.92851   16.61878  1.000 10.02409 ? 126 PHE   B CA  1 
ATOM   3841 C C   . PHE   B 1 147 ? -22.69850 9.53640   15.39799  1.000 10.73037 ? 126 PHE   B C   1 
ATOM   3842 O O   . PHE   B 1 147 ? -23.52744 8.62390   15.44869  1.000 8.90555  ? 126 PHE   B O   1 
ATOM   3843 C CB  . PHE   B 1 147 ? -20.52718 9.19863   16.58520  1.000 10.01933 ? 126 PHE   B CB  1 
ATOM   3844 C CG  . PHE   B 1 147 ? -19.56294 9.62511   17.66343  1.000 9.15559  ? 126 PHE   B CG  1 
ATOM   3845 C CD1 . PHE   B 1 147 ? -18.96338 10.87328  17.62737  1.000 7.40916  ? 126 PHE   B CD1 1 
ATOM   3846 C CD2 . PHE   B 1 147 ? -19.24879 8.76735   18.70735  1.000 10.04507 ? 126 PHE   B CD2 1 
ATOM   3847 C CE1 . PHE   B 1 147 ? -18.07359 11.26086  18.61706  1.000 10.81306 ? 126 PHE   B CE1 1 
ATOM   3848 C CE2 . PHE   B 1 147 ? -18.36088 9.15004   19.69989  1.000 8.27304  ? 126 PHE   B CE2 1 
ATOM   3849 C CZ  . PHE   B 1 147 ? -17.77131 10.39732  19.65267  1.000 10.13101 ? 126 PHE   B CZ  1 
ATOM   3850 N N   . SER   B 1 148 ? -22.48425 10.24596  14.29613  1.000 9.30646  ? 127 SER   B N   1 
ATOM   3851 C CA  . SER   B 1 148 ? -23.12662 9.85104   13.05322  1.000 13.04466 ? 127 SER   B CA  1 
ATOM   3852 C C   . SER   B 1 148 ? -22.55742 8.51574   12.58244  1.000 16.83628 ? 127 SER   B C   1 
ATOM   3853 O O   . SER   B 1 148 ? -21.38136 8.20542   12.79461  1.000 9.52685  ? 127 SER   B O   1 
ATOM   3854 C CB  . SER   B 1 148 ? -22.94973 10.92910  11.98202  1.000 16.87727 ? 127 SER   B CB  1 
ATOM   3855 O OG  . SER   B 1 148 ? -21.59143 11.10279  11.63067  1.000 24.61899 ? 127 SER   B OG  1 
ATOM   3856 N N   . SER   B 1 149 ? -23.41396 7.70809   11.95405  1.000 7.06595  ? 128 SER   B N   1 
ATOM   3857 C CA  . SER   B 1 149 ? -23.01264 6.35174   11.59507  1.000 8.60364  ? 128 SER   B CA  1 
ATOM   3858 C C   . SER   B 1 149 ? -21.89512 6.32127   10.55945  1.000 9.42283  ? 128 SER   B C   1 
ATOM   3859 O O   . SER   B 1 149 ? -21.26526 5.27352   10.38348  1.000 9.82232  ? 128 SER   B O   1 
ATOM   3860 C CB  . SER   B 1 149 ? -24.22231 5.56095   11.09318  1.000 15.50398 ? 128 SER   B CB  1 
ATOM   3861 O OG  . SER   B 1 149 ? -25.07888 5.21972   12.17231  1.000 22.86984 ? 128 SER   B OG  1 
ATOM   3862 N N   . THR   B 1 150 ? -21.62120 7.43957   9.88563   1.000 5.73352  ? 129 THR   B N   1 
ATOM   3863 C CA  . THR   B 1 150 ? -20.54019 7.52507   8.91178   1.000 5.96480  ? 129 THR   B CA  1 
ATOM   3864 C C   . THR   B 1 150 ? -19.27007 8.12626   9.50527   1.000 9.30178  ? 129 THR   B C   1 
ATOM   3865 O O   . THR   B 1 150 ? -18.39487 8.58294   8.75934   1.000 8.50602  ? 129 THR   B O   1 
ATOM   3866 C CB  . THR   B 1 150 ? -20.98436 8.32544   7.68586   1.000 8.70497  ? 129 THR   B CB  1 
ATOM   3867 O OG1 . THR   B 1 150 ? -21.39627 9.63655   8.08805   1.000 11.05776 ? 129 THR   B OG1 1 
ATOM   3868 C CG2 . THR   B 1 150 ? -22.14208 7.62422   6.99514   1.000 11.51282 ? 129 THR   B CG2 1 
ATOM   3869 N N   . LEU   B 1 151 ? -19.15586 8.12466   10.83115  1.000 7.83412  ? 130 LEU   B N   1 
ATOM   3870 C CA  . LEU   B 1 151 ? -17.96273 8.62221   11.50266  1.000 9.80333  ? 130 LEU   B CA  1 
ATOM   3871 C C   . LEU   B 1 151 ? -16.71518 7.90846   10.99519  1.000 7.94128  ? 130 LEU   B C   1 
ATOM   3872 O O   . LEU   B 1 151 ? -16.70567 6.68435   10.84047  1.000 9.42288  ? 130 LEU   B O   1 
ATOM   3873 C CB  . LEU   B 1 151 ? -18.11031 8.41276   13.00987  1.000 8.06959  ? 130 LEU   B CB  1 
ATOM   3874 C CG  . LEU   B 1 151 ? -16.92545 8.71637   13.92145  1.000 9.37570  ? 130 LEU   B CG  1 
ATOM   3875 C CD1 . LEU   B 1 151 ? -16.80777 10.21044  14.16257  1.000 8.85130  ? 130 LEU   B CD1 1 
ATOM   3876 C CD2 . LEU   B 1 151 ? -17.07502 7.95579   15.23144  1.000 7.51737  ? 130 LEU   B CD2 1 
ATOM   3877 N N   . LYS   B 1 152 ? -15.66634 8.68002   10.72186  1.000 8.31724  ? 131 LYS   B N   1 
ATOM   3878 C CA  . LYS   B 1 152 ? -14.37177 8.10440   10.38873  1.000 6.72297  ? 131 LYS   B CA  1 
ATOM   3879 C C   . LYS   B 1 152 ? -13.64241 7.71696   11.66621  1.000 5.75916  ? 131 LYS   B C   1 
ATOM   3880 O O   . LYS   B 1 152 ? -13.65653 8.45718   12.65296  1.000 6.80720  ? 131 LYS   B O   1 
ATOM   3881 C CB  . LYS   B 1 152 ? -13.52913 9.09454   9.58489   1.000 10.71003 ? 131 LYS   B CB  1 
ATOM   3882 C CG  . LYS   B 1 152 ? -14.01414 9.32376   8.16445   1.000 11.28019 ? 131 LYS   B CG  1 
ATOM   3883 C CD  . LYS   B 1 152 ? -12.90441 9.89369   7.29777   1.000 16.69051 ? 131 LYS   B CD  1 
ATOM   3884 C CE  . LYS   B 1 152 ? -13.45059 10.42097  5.98097   1.000 18.81853 ? 131 LYS   B CE  1 
ATOM   3885 N NZ  . LYS   B 1 152 ? -12.50866 11.38167  5.34405   1.000 17.09063 ? 131 LYS   B NZ  1 
ATOM   3886 N N   . ARG   B 1 153 ? -13.00648 6.55034   11.64931  1.000 5.52580  ? 132 ARG   B N   1 
ATOM   3887 C CA  . ARG   B 1 153 ? -12.33438 6.02119   12.82627  1.000 6.50505  ? 132 ARG   B CA  1 
ATOM   3888 C C   . ARG   B 1 153 ? -10.87392 5.73571   12.50532  1.000 9.76160  ? 132 ARG   B C   1 
ATOM   3889 O O   . ARG   B 1 153 ? -10.52581 5.42195   11.36611  1.000 6.58002  ? 132 ARG   B O   1 
ATOM   3890 C CB  . ARG   B 1 153 ? -13.02638 4.74947   13.32710  1.000 5.75360  ? 132 ARG   B CB  1 
ATOM   3891 C CG  . ARG   B 1 153 ? -14.46527 4.98056   13.78121  1.000 6.40282  ? 132 ARG   B CG  1 
ATOM   3892 C CD  . ARG   B 1 153 ? -15.07894 3.71097   14.34430  1.000 16.44948 ? 132 ARG   B CD  1 
ATOM   3893 N NE  . ARG   B 1 153 ? -15.27957 2.68829   13.32633  1.000 15.63580 ? 132 ARG   B NE  1 
ATOM   3894 C CZ  . ARG   B 1 153 ? -14.84253 1.44019   13.42611  1.000 14.66894 ? 132 ARG   B CZ  1 
ATOM   3895 N NH1 . ARG   B 1 153 ? -14.11076 1.04407   14.45446  1.000 14.74169 ? 132 ARG   B NH1 1 
ATOM   3896 N NH2 . ARG   B 1 153 ? -15.14405 0.56829   12.46839  1.000 9.83758  ? 132 ARG   B NH2 1 
ATOM   3897 N N   . LEU   B 1 154 ? -10.01644 5.87532   13.51610  1.000 7.47032  ? 133 LEU   B N   1 
ATOM   3898 C CA  . LEU   B 1 154 ? -8.58560  5.59197   13.38458  1.000 5.94271  ? 133 LEU   B CA  1 
ATOM   3899 C C   . LEU   B 1 154 ? -8.12658  4.79425   14.59488  1.000 8.85594  ? 133 LEU   B C   1 
ATOM   3900 O O   . LEU   B 1 154 ? -7.51739  5.33538   15.52642  1.000 7.97666  ? 133 LEU   B O   1 
ATOM   3901 C CB  . LEU   B 1 154 ? -7.77483  6.88138   13.23272  1.000 3.92411  ? 133 LEU   B CB  1 
ATOM   3902 C CG  . LEU   B 1 154 ? -6.28163  6.70339   12.92999  1.000 8.81275  ? 133 LEU   B CG  1 
ATOM   3903 C CD1 . LEU   B 1 154 ? -6.08258  5.90437   11.65356  1.000 13.82035 ? 133 LEU   B CD1 1 
ATOM   3904 C CD2 . LEU   B 1 154 ? -5.58869  8.05352   12.82382  1.000 9.32466  ? 133 LEU   B CD2 1 
ATOM   3905 N N   . PRO   B 1 155 ? -8.40195  3.49036   14.61680  1.000 8.15459  ? 134 PRO   B N   1 
ATOM   3906 C CA  . PRO   B 1 155 ? -8.00305  2.65844   15.75885  1.000 10.57114 ? 134 PRO   B CA  1 
ATOM   3907 C C   . PRO   B 1 155 ? -6.55950  2.20916   15.61337  1.000 6.04414  ? 134 PRO   B C   1 
ATOM   3908 O O   . PRO   B 1 155 ? -6.22517  1.41514   14.72843  1.000 9.36805  ? 134 PRO   B O   1 
ATOM   3909 C CB  . PRO   B 1 155 ? -8.98198  1.47896   15.68371  1.000 9.22285  ? 134 PRO   B CB  1 
ATOM   3910 C CG  . PRO   B 1 155 ? -9.37592  1.39645   14.22307  1.000 10.37970 ? 134 PRO   B CG  1 
ATOM   3911 C CD  . PRO   B 1 155 ? -8.99064  2.68592   13.53345  1.000 10.03467 ? 134 PRO   B CD  1 
ATOM   3912 N N   . MET   B 1 156 ? -5.69937  2.70596   16.49332  1.000 5.25552  ? 135 MET   B N   1 
ATOM   3913 C CA  . MET   B 1 156 ? -4.27528  2.42360   16.43104  1.000 13.05497 ? 135 MET   B CA  1 
ATOM   3914 C C   . MET   B 1 156 ? -3.86960  1.50235   17.57398  1.000 13.24178 ? 135 MET   B C   1 
ATOM   3915 O O   . MET   B 1 156 ? -4.46542  1.52432   18.65487  1.000 11.02985 ? 135 MET   B O   1 
ATOM   3916 C CB  . MET   B 1 156 ? -3.45525  3.71914   16.48038  1.000 9.55571  ? 135 MET   B CB  1 
ATOM   3917 C CG  . MET   B 1 156 ? -3.45427  4.50541   15.17754  1.000 8.93479  ? 135 MET   B CG  1 
ATOM   3918 S SD  . MET   B 1 156 ? -3.19235  6.28259   15.35848  1.000 16.32661 ? 135 MET   B SD  1 
ATOM   3919 C CE  . MET   B 1 156 ? -4.41352  6.73147   16.58634  1.000 11.11006 ? 135 MET   B CE  1 
ATOM   3920 N N   . ASN   B 1 157 ? -2.85224  0.68325   17.31667  1.000 9.44635  ? 136 ASN   B N   1 
ATOM   3921 C CA  . ASN   B 1 157 ? -2.33043  -0.24971  18.30454  1.000 16.37531 ? 136 ASN   B CA  1 
ATOM   3922 C C   . ASN   B 1 157 ? -0.86699  -0.51805  17.98028  1.000 14.55812 ? 136 ASN   B C   1 
ATOM   3923 O O   . ASN   B 1 157 ? -0.32485  -0.01092  16.99356  1.000 9.20508  ? 136 ASN   B O   1 
ATOM   3924 C CB  . ASN   B 1 157 ? -3.15018  -1.54569  18.33376  1.000 17.83418 ? 136 ASN   B CB  1 
ATOM   3925 C CG  . ASN   B 1 157 ? -3.13885  -2.21634  19.69749  1.000 15.34559 ? 136 ASN   B CG  1 
ATOM   3926 O OD1 . ASN   B 1 157 ? -2.17036  -2.10455  20.45433  1.000 14.34579 ? 136 ASN   B OD1 1 
ATOM   3927 N ND2 . ASN   B 1 157 ? -4.21815  -2.92317  20.01611  1.000 19.44706 ? 136 ASN   B ND2 1 
ATOM   3928 N N   . GLY   B 1 158 ? -0.22549  -1.31953  18.82633  1.000 13.01744 ? 137 GLY   B N   1 
ATOM   3929 C CA  . GLY   B 1 158 ? 1.17292   -1.63430  18.62211  1.000 6.46595  ? 137 GLY   B CA  1 
ATOM   3930 C C   . GLY   B 1 158 ? 2.11693   -0.48995  18.89546  1.000 9.97932  ? 137 GLY   B C   1 
ATOM   3931 O O   . GLY   B 1 158 ? 3.27452   -0.54176  18.47272  1.000 10.41717 ? 137 GLY   B O   1 
ATOM   3932 N N   . VAL   B 1 159 ? 1.65656   0.54371   19.59738  1.000 8.18169  ? 138 VAL   B N   1 
ATOM   3933 C CA  . VAL   B 1 159 ? 2.48668   1.70271   19.89619  1.000 6.93225  ? 138 VAL   B CA  1 
ATOM   3934 C C   . VAL   B 1 159 ? 2.76049   1.87710   21.38617  1.000 11.20568 ? 138 VAL   B C   1 
ATOM   3935 O O   . VAL   B 1 159 ? 3.69221   2.61663   21.74366  1.000 10.57516 ? 138 VAL   B O   1 
ATOM   3936 C CB  . VAL   B 1 159 ? 1.86135   2.98888   19.31680  1.000 12.05215 ? 138 VAL   B CB  1 
ATOM   3937 C CG1 . VAL   B 1 159 ? 1.98784   2.99944   17.79732  1.000 12.33519 ? 138 VAL   B CG1 1 
ATOM   3938 C CG2 . VAL   B 1 159 ? 0.39925   3.10326   19.73241  1.000 8.05825  ? 138 VAL   B CG2 1 
ATOM   3939 N N   . GLY   B 1 160 ? 1.98691   1.24908   22.26784  1.000 11.30021 ? 139 GLY   B N   1 
ATOM   3940 C CA  . GLY   B 1 160 ? 2.30099   1.27221   23.68917  1.000 8.30801  ? 139 GLY   B CA  1 
ATOM   3941 C C   . GLY   B 1 160 ? 2.33599   2.67228   24.27640  1.000 9.06936  ? 139 GLY   B C   1 
ATOM   3942 O O   . GLY   B 1 160 ? 1.47163   3.51050   24.00101  1.000 10.34972 ? 139 GLY   B O   1 
ATOM   3943 N N   . CYS   B 1 161 ? 3.36254   2.93142   25.09548  1.000 8.38315  ? 140 CYS   B N   1 
ATOM   3944 C CA  . CYS   B 1 161 ? 3.44005   4.16857   25.86916  1.000 12.65592 ? 140 CYS   B CA  1 
ATOM   3945 C C   . CYS   B 1 161 ? 3.48141   5.40924   24.99082  1.000 7.71513  ? 140 CYS   B C   1 
ATOM   3946 O O   . CYS   B 1 161 ? 3.11845   6.49652   25.45120  1.000 12.48050 ? 140 CYS   B O   1 
ATOM   3947 C CB  . CYS   B 1 161 ? 4.67801   4.15095   26.77001  1.000 16.15759 ? 140 CYS   B CB  1 
ATOM   3948 S SG  . CYS   B 1 161 ? 4.54441   3.11642   28.24863  1.000 24.24137 ? 140 CYS   B SG  1 
ATOM   3949 N N   . MET   B 1 162 ? 3.91722   5.27406   23.74653  1.000 6.53105  ? 141 MET   B N   1 
ATOM   3950 C CA  . MET   B 1 162 ? 4.06650   6.40922   22.85115  1.000 6.52043  ? 141 MET   B CA  1 
ATOM   3951 C C   . MET   B 1 162 ? 2.75508   6.78798   22.16596  1.000 7.74749  ? 141 MET   B C   1 
ATOM   3952 O O   . MET   B 1 162 ? 2.69184   7.83687   21.51649  1.000 7.59592  ? 141 MET   B O   1 
ATOM   3953 C CB  . MET   B 1 162 ? 5.17804   6.07566   21.84373  1.000 11.08649 ? 141 MET   B CB  1 
ATOM   3954 C CG  . MET   B 1 162 ? 5.42134   7.05091   20.71373  1.000 18.29436 ? 141 MET   B CG  1 
ATOM   3955 S SD  . MET   B 1 162 ? 6.35836   6.25528   19.39326  1.000 22.92884 ? 141 MET   B SD  1 
ATOM   3956 C CE  . MET   B 1 162 ? 5.11089   5.19804   18.66873  1.000 15.86018 ? 141 MET   B CE  1 
ATOM   3957 N N   . GLY   B 1 163 ? 1.69221   6.00175   22.36878  1.000 9.11550  ? 142 GLY   B N   1 
ATOM   3958 C CA  . GLY   B 1 163 ? 0.47758   6.15563   21.57734  1.000 9.42960  ? 142 GLY   B CA  1 
ATOM   3959 C C   . GLY   B 1 163 ? -0.19914  7.50768   21.70545  1.000 9.10703  ? 142 GLY   B C   1 
ATOM   3960 O O   . GLY   B 1 163 ? -0.81654  7.98629   20.74941  1.000 5.99421  ? 142 GLY   B O   1 
ATOM   3961 N N   . GLY   B 1 164 ? -0.11674  8.13327   22.88082  1.000 7.86456  ? 143 GLY   B N   1 
ATOM   3962 C CA  . GLY   B 1 164 ? -0.73753  9.43941   23.04652  1.000 8.92918  ? 143 GLY   B CA  1 
ATOM   3963 C C   . GLY   B 1 164 ? -0.16014  10.48316  22.10903  1.000 9.96811  ? 143 GLY   B C   1 
ATOM   3964 O O   . GLY   B 1 164 ? -0.89270  11.15568  21.37740  1.000 5.91307  ? 143 GLY   B O   1 
ATOM   3965 N N   . ALA   B 1 165 ? 1.16746   10.62413  22.10790  1.000 6.16761  ? 144 ALA   B N   1 
ATOM   3966 C CA  . ALA   B 1 165 ? 1.80684   11.55318  21.18032  1.000 7.62718  ? 144 ALA   B CA  1 
ATOM   3967 C C   . ALA   B 1 165 ? 1.70046   11.05883  19.74343  1.000 6.24068  ? 144 ALA   B C   1 
ATOM   3968 O O   . ALA   B 1 165 ? 1.55615   11.85985  18.81221  1.000 7.47065  ? 144 ALA   B O   1 
ATOM   3969 C CB  . ALA   B 1 165 ? 3.27007   11.76310  21.56939  1.000 7.02923  ? 144 ALA   B CB  1 
ATOM   3970 N N   . PHE   B 1 166 ? 1.77816   9.74184   19.54698  1.000 5.65550  ? 145 PHE   B N   1 
ATOM   3971 C CA  . PHE   B 1 166 ? 1.63177   9.17485   18.21148  1.000 8.20925  ? 145 PHE   B CA  1 
ATOM   3972 C C   . PHE   B 1 166 ? 0.27948   9.53310   17.60897  1.000 10.49775 ? 145 PHE   B C   1 
ATOM   3973 O O   . PHE   B 1 166 ? 0.19796   9.93406   16.44186  1.000 10.13013 ? 145 PHE   B O   1 
ATOM   3974 C CB  . PHE   B 1 166 ? 1.80554   7.65805   18.28078  1.000 7.59426  ? 145 PHE   B CB  1 
ATOM   3975 C CG  . PHE   B 1 166 ? 1.91457   6.99515   16.94334  1.000 13.17326 ? 145 PHE   B CG  1 
ATOM   3976 C CD1 . PHE   B 1 166 ? 3.13955   6.88321   16.31328  1.000 13.17344 ? 145 PHE   B CD1 1 
ATOM   3977 C CD2 . PHE   B 1 166 ? 0.79546   6.46444   16.32412  1.000 13.87780 ? 145 PHE   B CD2 1 
ATOM   3978 C CE1 . PHE   B 1 166 ? 3.24620   6.26412   15.08367  1.000 13.13738 ? 145 PHE   B CE1 1 
ATOM   3979 C CE2 . PHE   B 1 166 ? 0.89568   5.84597   15.09678  1.000 11.28035 ? 145 PHE   B CE2 1 
ATOM   3980 C CZ  . PHE   B 1 166 ? 2.12268   5.74298   14.47796  1.000 12.38178 ? 145 PHE   B CZ  1 
ATOM   3981 N N   . GLY   B 1 167 ? -0.78946  9.41252   18.39967  1.000 6.45232  ? 146 GLY   B N   1 
ATOM   3982 C CA  . GLY   B 1 167 ? -2.11714  9.72843   17.89696  1.000 10.82872 ? 146 GLY   B CA  1 
ATOM   3983 C C   . GLY   B 1 167 ? -2.28004  11.19105  17.53139  1.000 7.68365  ? 146 GLY   B C   1 
ATOM   3984 O O   . GLY   B 1 167 ? -2.90957  11.52069  16.52387  1.000 5.25080  ? 146 GLY   B O   1 
ATOM   3985 N N   . ILE   B 1 168 ? -1.71166  12.08870  18.34002  1.000 10.54734 ? 147 ILE   B N   1 
ATOM   3986 C CA  . ILE   B 1 168 ? -1.79274  13.51143  18.02341  1.000 7.52594  ? 147 ILE   B CA  1 
ATOM   3987 C C   . ILE   B 1 168 ? -1.16748  13.78385  16.66260  1.000 6.87907  ? 147 ILE   B C   1 
ATOM   3988 O O   . ILE   B 1 168 ? -1.72607  14.52378  15.84232  1.000 6.60847  ? 147 ILE   B O   1 
ATOM   3989 C CB  . ILE   B 1 168 ? -1.13234  14.34945  19.13413  1.000 7.60260  ? 147 ILE   B CB  1 
ATOM   3990 C CG1 . ILE   B 1 168 ? -1.96742  14.28545  20.41398  1.000 8.03528  ? 147 ILE   B CG1 1 
ATOM   3991 C CG2 . ILE   B 1 168 ? -0.96454  15.79601  18.68663  1.000 8.96813  ? 147 ILE   B CG2 1 
ATOM   3992 C CD1 . ILE   B 1 168 ? -1.29295  14.91959  21.61942  1.000 8.64361  ? 147 ILE   B CD1 1 
ATOM   3993 N N   . SER   B 1 169 ? -0.01839  13.16159  16.38569  1.000 5.59563  ? 148 SER   B N   1 
ATOM   3994 C CA  . SER   B 1 169 ? 0.63647   13.35663  15.09561  1.000 10.81221 ? 148 SER   B CA  1 
ATOM   3995 C C   . SER   B 1 169 ? -0.21571  12.83268  13.94706  1.000 12.02331 ? 148 SER   B C   1 
ATOM   3996 O O   . SER   B 1 169 ? -0.35075  13.49889  12.91452  1.000 10.68598 ? 148 SER   B O   1 
ATOM   3997 C CB  . SER   B 1 169 ? 2.00344   12.67387  15.08794  1.000 7.92584  ? 148 SER   B CB  1 
ATOM   3998 O OG  . SER   B 1 169 ? 2.87169   13.24908  16.04432  1.000 14.11470 ? 148 SER   B OG  1 
ATOM   3999 N N   . ARG   B 1 170 ? -0.78961  11.63661  14.09809  1.000 7.02124  ? 149 ARG   B N   1 
ATOM   4000 C CA  . ARG   B 1 170 ? -1.56632  11.06777  13.00061  1.000 7.10744  ? 149 ARG   B CA  1 
ATOM   4001 C C   . ARG   B 1 170 ? -2.83116  11.87837  12.73717  1.000 7.82744  ? 149 ARG   B C   1 
ATOM   4002 O O   . ARG   B 1 170 ? -3.21142  12.08470  11.57802  1.000 7.06461  ? 149 ARG   B O   1 
ATOM   4003 C CB  . ARG   B 1 170 ? -1.89203  9.60182   13.29022  1.000 7.66659  ? 149 ARG   B CB  1 
ATOM   4004 C CG  . ARG   B 1 170 ? -0.67349  8.76485   13.70023  1.000 8.65074  ? 149 ARG   B CG  1 
ATOM   4005 C CD  . ARG   B 1 170 ? 0.20310   8.35526   12.51601  1.000 10.06186 ? 149 ARG   B CD  1 
ATOM   4006 N NE  . ARG   B 1 170 ? 0.92990   9.47183   11.92046  1.000 11.02692 ? 149 ARG   B NE  1 
ATOM   4007 C CZ  . ARG   B 1 170 ? 2.09283   9.94104   12.35264  1.000 19.03948 ? 149 ARG   B CZ  1 
ATOM   4008 N NH1 . ARG   B 1 170 ? 2.71422   9.40542   13.39219  1.000 13.56698 ? 149 ARG   B NH1 1 
ATOM   4009 N NH2 . ARG   B 1 170 ? 2.64625   10.97607  11.72530  1.000 11.11357 ? 149 ARG   B NH2 1 
ATOM   4010 N N   . VAL   B 1 171 ? -3.48933  12.35444  13.79642  1.000 5.90274  ? 150 VAL   B N   1 
ATOM   4011 C CA  . VAL   B 1 171 ? -4.67705  13.18752  13.62359  1.000 8.79382  ? 150 VAL   B CA  1 
ATOM   4012 C C   . VAL   B 1 171 ? -4.30889  14.52170  12.98460  1.000 10.97026 ? 150 VAL   B C   1 
ATOM   4013 O O   . VAL   B 1 171 ? -5.02893  15.02896  12.11531  1.000 10.84527 ? 150 VAL   B O   1 
ATOM   4014 C CB  . VAL   B 1 171 ? -5.39029  13.38084  14.97525  1.000 5.35692  ? 150 VAL   B CB  1 
ATOM   4015 C CG1 . VAL   B 1 171 ? -6.48862  14.42950  14.86389  1.000 6.60025  ? 150 VAL   B CG1 1 
ATOM   4016 C CG2 . VAL   B 1 171 ? -5.95119  12.05868  15.47140  1.000 9.81028  ? 150 VAL   B CG2 1 
ATOM   4017 N N   . ALA   B 1 172 ? -3.18679  15.11444  13.40527  1.000 9.99858  ? 151 ALA   B N   1 
ATOM   4018 C CA  . ALA   B 1 172 ? -2.75095  16.37406  12.81088  1.000 11.29723 ? 151 ALA   B CA  1 
ATOM   4019 C C   . ALA   B 1 172 ? -2.49771  16.21730  11.31741  1.000 12.02531 ? 151 ALA   B C   1 
ATOM   4020 O O   . ALA   B 1 172 ? -2.85530  17.09640  10.52323  1.000 11.79759 ? 151 ALA   B O   1 
ATOM   4021 C CB  . ALA   B 1 172 ? -1.49498  16.88522  13.51646  1.000 10.82291 ? 151 ALA   B CB  1 
ATOM   4022 N N   . ASP   B 1 173 ? -1.88763  15.09880  10.91530  1.000 9.43711  ? 152 ASP   B N   1 
ATOM   4023 C CA  . ASP   B 1 173 ? -1.66202  14.85074  9.49478   1.000 9.33458  ? 152 ASP   B CA  1 
ATOM   4024 C C   . ASP   B 1 173 ? -2.97936  14.72840  8.73852   1.000 10.88119 ? 152 ASP   B C   1 
ATOM   4025 O O   . ASP   B 1 173 ? -3.08023  15.15491  7.58269   1.000 12.05945 ? 152 ASP   B O   1 
ATOM   4026 C CB  . ASP   B 1 173 ? -0.81791  13.59014  9.30503   1.000 12.32831 ? 152 ASP   B CB  1 
ATOM   4027 C CG  . ASP   B 1 173 ? 0.66626   13.84356  9.50560   1.000 15.06594 ? 152 ASP   B CG  1 
ATOM   4028 O OD1 . ASP   B 1 173 ? 1.03078   14.95667  9.93847   1.000 15.89970 ? 152 ASP   B OD1 1 
ATOM   4029 O OD2 . ASP   B 1 173 ? 1.46977   12.93045  9.22154   1.000 16.29164 ? 152 ASP   B OD2 1 
ATOM   4030 N N   . TYR   B 1 174 ? -3.99605  14.13154  9.36476   1.000 11.07740 ? 153 TYR   B N   1 
ATOM   4031 C CA  . TYR   B 1 174 ? -5.30744  14.05239  8.72642   1.000 9.18217  ? 153 TYR   B CA  1 
ATOM   4032 C C   . TYR   B 1 174 ? -5.92966  15.43437  8.57334   1.000 13.59975 ? 153 TYR   B C   1 
ATOM   4033 O O   . TYR   B 1 174 ? -6.43815  15.78358  7.50182   1.000 16.78257 ? 153 TYR   B O   1 
ATOM   4034 C CB  . TYR   B 1 174 ? -6.23740  13.13935  9.52797   1.000 12.43795 ? 153 TYR   B CB  1 
ATOM   4035 C CG  . TYR   B 1 174 ? -7.67731  13.16350  9.04216   1.000 12.39676 ? 153 TYR   B CG  1 
ATOM   4036 C CD1 . TYR   B 1 174 ? -8.09400  12.34016  8.00518   1.000 17.57330 ? 153 TYR   B CD1 1 
ATOM   4037 C CD2 . TYR   B 1 174 ? -8.61659  14.01432  9.61863   1.000 12.63733 ? 153 TYR   B CD2 1 
ATOM   4038 C CE1 . TYR   B 1 174 ? -9.40373  12.35891  7.55720   1.000 22.57487 ? 153 TYR   B CE1 1 
ATOM   4039 C CE2 . TYR   B 1 174 ? -9.92702  14.04178  9.17348   1.000 12.22209 ? 153 TYR   B CE2 1 
ATOM   4040 C CZ  . TYR   B 1 174 ? -10.31381 13.21170  8.14420   1.000 17.54722 ? 153 TYR   B CZ  1 
ATOM   4041 O OH  . TYR   B 1 174 ? -11.61523 13.23427  7.69948   1.000 18.86443 ? 153 TYR   B OH  1 
ATOM   4042 N N   . LEU   B 1 175 ? -5.90628  16.23446  9.63977   1.000 10.41076 ? 154 LEU   B N   1 
ATOM   4043 C CA  . LEU   B 1 175 ? -6.54685  17.54288  9.60573   1.000 11.79707 ? 154 LEU   B CA  1 
ATOM   4044 C C   . LEU   B 1 175 ? -5.82395  18.52428  8.69132   1.000 17.53789 ? 154 LEU   B C   1 
ATOM   4045 O O   . LEU   B 1 175 ? -6.39835  19.56588  8.35150   1.000 15.17443 ? 154 LEU   B O   1 
ATOM   4046 C CB  . LEU   B 1 175 ? -6.65937  18.09852  11.02755  1.000 12.28869 ? 154 LEU   B CB  1 
ATOM   4047 C CG  . LEU   B 1 175 ? -7.64128  17.30180  11.89949  1.000 8.58570  ? 154 LEU   B CG  1 
ATOM   4048 C CD1 . LEU   B 1 175 ? -7.63823  17.76898  13.34841  1.000 12.54462 ? 154 LEU   B CD1 1 
ATOM   4049 C CD2 . LEU   B 1 175 ? -9.05107  17.35306  11.32662  1.000 10.29838 ? 154 LEU   B CD2 1 
ATOM   4050 N N   . LYS   B 1 176 ? -4.59212  18.21025  8.27730   1.000 14.57473 ? 155 LYS   B N   1 
ATOM   4051 C CA  . LYS   B 1 176 ? -3.92990  18.99612  7.24029   1.000 15.55581 ? 155 LYS   B CA  1 
ATOM   4052 C C   . LYS   B 1 176 ? -4.76918  19.04454  5.96927   1.000 17.12321 ? 155 LYS   B C   1 
ATOM   4053 O O   . LYS   B 1 176 ? -4.82693  20.07760  5.29164   1.000 17.81970 ? 155 LYS   B O   1 
ATOM   4054 C CB  . LYS   B 1 176 ? -2.55573  18.40440  6.92935   1.000 16.18885 ? 155 LYS   B CB  1 
ATOM   4055 C CG  . LYS   B 1 176 ? -1.42926  18.83216  7.84429   1.000 18.56327 ? 155 LYS   B CG  1 
ATOM   4056 C CD  . LYS   B 1 176 ? -0.09542  18.38724  7.25961   1.000 23.81043 ? 155 LYS   B CD  1 
ATOM   4057 C CE  . LYS   B 1 176 ? 0.80712   17.79948  8.32650   1.000 23.62868 ? 155 LYS   B CE  1 
ATOM   4058 N NZ  . LYS   B 1 176 ? 1.91174   16.99115  7.73807   1.000 25.86110 ? 155 LYS   B NZ  1 
ATOM   4059 N N   . ALA   B 1 177 ? -5.41430  17.93085  5.62393   1.000 23.49087 ? 156 ALA   B N   1 
ATOM   4060 C CA  . ALA   B 1 177 ? -6.23595  17.82850  4.42536   1.000 27.44120 ? 156 ALA   B CA  1 
ATOM   4061 C C   . ALA   B 1 177 ? -7.70339  18.13739  4.68103   1.000 23.86168 ? 156 ALA   B C   1 
ATOM   4062 O O   . ALA   B 1 177 ? -8.50921  18.05919  3.74858   1.000 19.28849 ? 156 ALA   B O   1 
ATOM   4063 C CB  . ALA   B 1 177 ? -6.11642  16.42546  3.81969   1.000 23.34090 ? 156 ALA   B CB  1 
ATOM   4064 N N   . HIS   B 1 178 ? -8.07461  18.46811  5.91426   1.000 20.81254 ? 157 HIS   B N   1 
ATOM   4065 C CA  . HIS   B 1 178 ? -9.47208  18.69841  6.28116   1.000 16.66937 ? 157 HIS   B CA  1 
ATOM   4066 C C   . HIS   B 1 178 ? -9.54300  19.88675  7.22852   1.000 14.92582 ? 157 HIS   B C   1 
ATOM   4067 O O   . HIS   B 1 178 ? -9.77526  19.73431  8.43233   1.000 15.18651 ? 157 HIS   B O   1 
ATOM   4068 C CB  . HIS   B 1 178 ? -10.07050 17.43797  6.90628   1.000 15.89009 ? 157 HIS   B CB  1 
ATOM   4069 C CG  . HIS   B 1 178 ? -9.96446  16.22799  6.03105   1.000 18.70615 ? 157 HIS   B CG  1 
ATOM   4070 N ND1 . HIS   B 1 178 ? -8.84013  15.43084  5.99816   1.000 23.06370 ? 157 HIS   B ND1 1 
ATOM   4071 C CD2 . HIS   B 1 178 ? -10.84028 15.67906  5.15693   1.000 20.01491 ? 157 HIS   B CD2 1 
ATOM   4072 C CE1 . HIS   B 1 178 ? -9.02616  14.44675  5.13731   1.000 19.46828 ? 157 HIS   B CE1 1 
ATOM   4073 N NE2 . HIS   B 1 178 ? -10.23427 14.57048  4.61804   1.000 17.68170 ? 157 HIS   B NE2 1 
ATOM   4074 N N   . PRO   B 1 179 ? -9.34327  21.10107  6.70871   1.000 16.31611 ? 158 PRO   B N   1 
ATOM   4075 C CA  . PRO   B 1 179 ? -9.25524  22.27380  7.59457   1.000 19.97996 ? 158 PRO   B CA  1 
ATOM   4076 C C   . PRO   B 1 179 ? -10.55476 22.62686  8.30154   1.000 14.81325 ? 158 PRO   B C   1 
ATOM   4077 O O   . PRO   B 1 179 ? -10.51732 23.39672  9.26927   1.000 19.57143 ? 158 PRO   B O   1 
ATOM   4078 C CB  . PRO   B 1 179 ? -8.81959  23.39691  6.64314   1.000 24.40405 ? 158 PRO   B CB  1 
ATOM   4079 C CG  . PRO   B 1 179 ? -9.31257  22.96005  5.30791   1.000 20.16400 ? 158 PRO   B CG  1 
ATOM   4080 C CD  . PRO   B 1 179 ? -9.14113  21.46473  5.29587   1.000 17.45069 ? 158 PRO   B CD  1 
ATOM   4081 N N   . LYS   B 1 180 ? -11.69862 22.11289  7.85201   1.000 20.96887 ? 159 LYS   B N   1 
ATOM   4082 C CA  . LYS   B 1 180 ? -12.98200 22.45587  8.45184   1.000 21.23253 ? 159 LYS   B CA  1 
ATOM   4083 C C   . LYS   B 1 180 ? -13.44569 21.45394  9.50230   1.000 14.85512 ? 159 LYS   B C   1 
ATOM   4084 O O   . LYS   B 1 180 ? -14.45498 21.70233  10.16910  1.000 16.88432 ? 159 LYS   B O   1 
ATOM   4085 C CB  . LYS   B 1 180 ? -14.05793 22.57240  7.36464   1.000 19.66457 ? 159 LYS   B CB  1 
ATOM   4086 C CG  . LYS   B 1 180 ? -13.83255 23.70432  6.37306   1.000 26.92142 ? 159 LYS   B CG  1 
ATOM   4087 C CD  . LYS   B 1 180 ? -14.31050 25.03860  6.92331   1.000 38.25003 ? 159 LYS   B CD  1 
ATOM   4088 C CE  . LYS   B 1 180 ? -15.66478 24.91536  7.60455   1.000 46.68503 ? 159 LYS   B CE  1 
ATOM   4089 N NZ  . LYS   B 1 180 ? -15.84878 25.95154  8.65974   1.000 46.98961 ? 159 LYS   B NZ  1 
ATOM   4090 N N   . GLU   B 1 181 ? -12.73185 20.35098  9.68182   1.000 13.66189 ? 160 GLU   B N   1 
ATOM   4091 C CA  . GLU   B 1 181 ? -13.21610 19.21700  10.45379  1.000 9.24731  ? 160 GLU   B CA  1 
ATOM   4092 C C   . GLU   B 1 181 ? -12.71699 19.26097  11.89415  1.000 12.06879 ? 160 GLU   B C   1 
ATOM   4093 O O   . GLU   B 1 181 ? -11.75896 19.95976  12.23045  1.000 14.77895 ? 160 GLU   B O   1 
ATOM   4094 C CB  . GLU   B 1 181 ? -12.78760 17.90840  9.78320   1.000 12.45033 ? 160 GLU   B CB  1 
ATOM   4095 C CG  . GLU   B 1 181 ? -13.27663 17.78841  8.34542   1.000 11.01004 ? 160 GLU   B CG  1 
ATOM   4096 C CD  . GLU   B 1 181 ? -13.30781 16.35997  7.85296   1.000 11.73923 ? 160 GLU   B CD  1 
ATOM   4097 O OE1 . GLU   B 1 181 ? -12.72677 15.48434  8.52727   1.000 12.32347 ? 160 GLU   B OE1 1 
ATOM   4098 O OE2 . GLU   B 1 181 ? -13.92351 16.10826  6.79692   1.000 17.31884 ? 160 GLU   B OE2 1 
ATOM   4099 N N   . ALA   B 1 182 ? -13.40174 18.50684  12.74911  1.000 10.93117 ? 161 ALA   B N   1 
ATOM   4100 C CA  . ALA   B 1 182 ? -13.00837 18.31436  14.13569  1.000 9.95759  ? 161 ALA   B CA  1 
ATOM   4101 C C   . ALA   B 1 182 ? -12.78174 16.83074  14.38148  1.000 6.67858  ? 161 ALA   B C   1 
ATOM   4102 O O   . ALA   B 1 182 ? -13.48794 15.98240  13.82483  1.000 5.59812  ? 161 ALA   B O   1 
ATOM   4103 C CB  . ALA   B 1 182 ? -14.06783 18.85606  15.10442  1.000 7.96325  ? 161 ALA   B CB  1 
ATOM   4104 N N   . ALA   B 1 183 ? -11.78923 16.52067  15.20802  1.000 7.91759  ? 162 ALA   B N   1 
ATOM   4105 C CA  . ALA   B 1 183 ? -11.45061 15.14572  15.52756  1.000 4.56162  ? 162 ALA   B CA  1 
ATOM   4106 C C   . ALA   B 1 183 ? -11.22776 15.01012  17.02399  1.000 5.81629  ? 162 ALA   B C   1 
ATOM   4107 O O   . ALA   B 1 183 ? -10.77662 15.94453  17.69143  1.000 6.95241  ? 162 ALA   B O   1 
ATOM   4108 C CB  . ALA   B 1 183 ? -10.19739 14.67928  14.77168  1.000 4.41065  ? 162 ALA   B CB  1 
ATOM   4109 N N   . ILE   B 1 184 ? -11.55384 13.83452  17.54526  1.000 5.38803  ? 163 ILE   B N   1 
ATOM   4110 C CA  . ILE   B 1 184 ? -11.29299 13.49124  18.93502  1.000 6.14408  ? 163 ILE   B CA  1 
ATOM   4111 C C   . ILE   B 1 184 ? -10.31115 12.32990  18.94932  1.000 5.41895  ? 163 ILE   B C   1 
ATOM   4112 O O   . ILE   B 1 184 ? -10.46535 11.37089  18.18372  1.000 6.39399  ? 163 ILE   B O   1 
ATOM   4113 C CB  . ILE   B 1 184 ? -12.58589 13.13390  19.69212  1.000 4.89937  ? 163 ILE   B CB  1 
ATOM   4114 C CG1 . ILE   B 1 184 ? -13.42269 14.38848  19.94253  1.000 4.93670  ? 163 ILE   B CG1 1 
ATOM   4115 C CG2 . ILE   B 1 184 ? -12.26436 12.45636  21.02069  1.000 5.40073  ? 163 ILE   B CG2 1 
ATOM   4116 C CD1 . ILE   B 1 184 ? -14.85570 14.09730  20.33152  1.000 10.39370 ? 163 ILE   B CD1 1 
ATOM   4117 N N   . LEU   B 1 185 ? -9.28919  12.43346  19.79415  1.000 8.05425  ? 164 LEU   B N   1 
ATOM   4118 C CA  . LEU   B 1 185 ? -8.37159  11.33771  20.06928  1.000 8.44127  ? 164 LEU   B CA  1 
ATOM   4119 C C   . LEU   B 1 185 ? -8.49919  10.97182  21.53839  1.000 7.63323  ? 164 LEU   B C   1 
ATOM   4120 O O   . LEU   B 1 185 ? -8.52936  11.85950  22.39675  1.000 5.44938  ? 164 LEU   B O   1 
ATOM   4121 C CB  . LEU   B 1 185 ? -6.92409  11.72331  19.74829  1.000 10.21344 ? 164 LEU   B CB  1 
ATOM   4122 C CG  . LEU   B 1 185 ? -5.85410  10.81547  20.35932  1.000 12.71609 ? 164 LEU   B CG  1 
ATOM   4123 C CD1 . LEU   B 1 185 ? -5.84599  9.47249   19.64288  1.000 10.14836 ? 164 LEU   B CD1 1 
ATOM   4124 C CD2 . LEU   B 1 185 ? -4.47447  11.46653  20.33530  1.000 9.74460  ? 164 LEU   B CD2 1 
ATOM   4125 N N   . PHE   B 1 186 ? -8.59032  9.67687   21.83117  1.000 6.34579  ? 165 PHE   B N   1 
ATOM   4126 C CA  . PHE   B 1 186 ? -8.52629  9.22181   23.20972  1.000 4.99961  ? 165 PHE   B CA  1 
ATOM   4127 C C   . PHE   B 1 186 ? -7.53075  8.07858   23.35127  1.000 6.35588  ? 165 PHE   B C   1 
ATOM   4128 O O   . PHE   B 1 186 ? -7.30742  7.29577   22.42207  1.000 5.79251  ? 165 PHE   B O   1 
ATOM   4129 C CB  . PHE   B 1 186 ? -9.90890  8.80462   23.76037  1.000 8.42511  ? 165 PHE   B CB  1 
ATOM   4130 C CG  . PHE   B 1 186 ? -10.47850 7.54914   23.15230  1.000 6.04652  ? 165 PHE   B CG  1 
ATOM   4131 C CD1 . PHE   B 1 186 ? -11.21339 7.60079   21.97789  1.000 7.09253  ? 165 PHE   B CD1 1 
ATOM   4132 C CD2 . PHE   B 1 186 ? -10.30334 6.32009   23.77438  1.000 5.00991  ? 165 PHE   B CD2 1 
ATOM   4133 C CE1 . PHE   B 1 186 ? -11.75417 6.45203   21.43032  1.000 5.26030  ? 165 PHE   B CE1 1 
ATOM   4134 C CE2 . PHE   B 1 186 ? -10.83751 5.16757   23.23263  1.000 5.45271  ? 165 PHE   B CE2 1 
ATOM   4135 C CZ  . PHE   B 1 186 ? -11.56569 5.23317   22.05619  1.000 6.85254  ? 165 PHE   B CZ  1 
ATOM   4136 N N   . ALA   B 1 187 ? -6.91967  8.01941   24.53367  1.000 7.79295  ? 166 ALA   B N   1 
ATOM   4137 C CA  . ALA   B 1 187 ? -5.99446  6.96805   24.92720  1.000 7.29267  ? 166 ALA   B CA  1 
ATOM   4138 C C   . ALA   B 1 187 ? -6.43650  6.42571   26.27420  1.000 6.06196  ? 166 ALA   B C   1 
ATOM   4139 O O   . ALA   B 1 187 ? -6.63719  7.19766   27.21682  1.000 8.83501  ? 166 ALA   B O   1 
ATOM   4140 C CB  . ALA   B 1 187 ? -4.56027  7.49685   25.02741  1.000 8.56859  ? 166 ALA   B CB  1 
ATOM   4141 N N   . VAL   B 1 188 ? -6.58189  5.10863   26.37283  1.000 5.97737  ? 167 VAL   B N   1 
ATOM   4142 C CA  . VAL   B 1 188 ? -6.96347  4.47603   27.63090  1.000 7.19893  ? 167 VAL   B CA  1 
ATOM   4143 C C   . VAL   B 1 188 ? -6.15803  3.19354   27.78527  1.000 7.57282  ? 167 VAL   B C   1 
ATOM   4144 O O   . VAL   B 1 188 ? -6.01286  2.42638   26.82815  1.000 9.05991  ? 167 VAL   B O   1 
ATOM   4145 C CB  . VAL   B 1 188 ? -8.48115  4.19936   27.69781  1.000 9.99182  ? 167 VAL   B CB  1 
ATOM   4146 C CG1 . VAL   B 1 188 ? -8.93768  3.34891   26.51812  1.000 8.98309  ? 167 VAL   B CG1 1 
ATOM   4147 C CG2 . VAL   B 1 188 ? -8.86487  3.55636   29.04053  1.000 4.80215  ? 167 VAL   B CG2 1 
ATOM   4148 N N   . GLU   B 1 189 ? -5.60645  2.97300   28.97752  1.000 6.83246  ? 168 GLU   B N   1 
ATOM   4149 C CA  . GLU   B 1 189 ? -4.86866  1.75052   29.25684  1.000 7.26480  ? 168 GLU   B CA  1 
ATOM   4150 C C   . GLU   B 1 189 ? -5.27830  1.21350   30.61870  1.000 7.11509  ? 168 GLU   B C   1 
ATOM   4151 O O   . GLU   B 1 189 ? -5.55672  1.98445   31.54114  1.000 6.68131  ? 168 GLU   B O   1 
ATOM   4152 C CB  . GLU   B 1 189 ? -3.35038  1.97501   29.20524  1.000 8.68286  ? 168 GLU   B CB  1 
ATOM   4153 C CG  . GLU   B 1 189 ? -2.83926  2.65486   27.92821  1.000 6.78455  ? 168 GLU   B CG  1 
ATOM   4154 C CD  . GLU   B 1 189 ? -2.91970  1.76748   26.69006  1.000 9.56038  ? 168 GLU   B CD  1 
ATOM   4155 O OE1 . GLU   B 1 189 ? -3.27320  0.57526   26.81777  1.000 11.73232 ? 168 GLU   B OE1 1 
ATOM   4156 O OE2 . GLU   B 1 189 ? -2.61932  2.26288   25.58224  1.000 8.92042  ? 168 GLU   B OE2 1 
ATOM   4157 N N   . ILE   B 1 190 ? -5.33502  -0.10733  30.73504  1.000 5.21495  ? 169 ILE   B N   1 
ATOM   4158 C CA  . ILE   B 1 190 ? -5.65758  -0.77065  31.99855  1.000 7.00627  ? 169 ILE   B CA  1 
ATOM   4159 C C   . ILE   B 1 190 ? -4.43198  -1.59554  32.37883  1.000 10.62244 ? 169 ILE   B C   1 
ATOM   4160 O O   . ILE   B 1 190 ? -4.37737  -2.80668  32.14565  1.000 9.83633  ? 169 ILE   B O   1 
ATOM   4161 C CB  . ILE   B 1 190 ? -6.91031  -1.64666  31.89344  1.000 9.38130  ? 169 ILE   B CB  1 
ATOM   4162 C CG1 . ILE   B 1 190 ? -8.05315  -0.87639  31.22541  1.000 12.45900 ? 169 ILE   B CG1 1 
ATOM   4163 C CG2 . ILE   B 1 190 ? -7.33086  -2.16164  33.26555  1.000 7.14498  ? 169 ILE   B CG2 1 
ATOM   4164 C CD1 . ILE   B 1 190 ? -8.61533  0.24539   32.06810  1.000 10.01877 ? 169 ILE   B CD1 1 
ATOM   4165 N N   . SER   B 1 191 ? -3.45369  -0.95813  33.02906  1.000 9.43983  ? 170 SER   B N   1 
ATOM   4166 C CA  . SER   B 1 191 ? -2.26560  -1.68910  33.45539  1.000 8.85191  ? 170 SER   B CA  1 
ATOM   4167 C C   . SER   B 1 191 ? -2.57761  -2.68528  34.55930  1.000 6.61236  ? 170 SER   B C   1 
ATOM   4168 O O   . SER   B 1 191 ? -1.84316  -3.66513  34.72206  1.000 8.85131  ? 170 SER   B O   1 
ATOM   4169 C CB  . SER   B 1 191 ? -1.18260  -0.71648  33.92016  1.000 11.13099 ? 170 SER   B CB  1 
ATOM   4170 O OG  . SER   B 1 191 ? -0.87143  0.22312   32.90892  1.000 10.74288 ? 170 SER   B OG  1 
ATOM   4171 N N   . SER   B 1 192 ? -3.66332  -2.47096  35.30192  1.000 8.84127  ? 171 SER   B N   1 
ATOM   4172 C CA  . SER   B 1 192 ? -4.01707  -3.38564  36.37560  1.000 9.54989  ? 171 SER   B CA  1 
ATOM   4173 C C   . SER   B 1 192 ? -4.41700  -4.76163  35.86092  1.000 10.35359 ? 171 SER   B C   1 
ATOM   4174 O O   . SER   B 1 192 ? -4.53098  -5.68908  36.66655  1.000 9.16868  ? 171 SER   B O   1 
ATOM   4175 C CB  . SER   B 1 192 ? -5.13704  -2.78514  37.23102  1.000 10.15594 ? 171 SER   B CB  1 
ATOM   4176 O OG  . SER   B 1 192 ? -6.33662  -2.62747  36.49398  1.000 9.97925  ? 171 SER   B OG  1 
ATOM   4177 N N   . ALA   B 1 193 ? -4.62109  -4.92162  34.54841  1.000 7.95576  ? 172 ALA   B N   1 
ATOM   4178 C CA  . ALA   B 1 193 ? -4.84871  -6.25494  33.99921  1.000 10.09638 ? 172 ALA   B CA  1 
ATOM   4179 C C   . ALA   B 1 193 ? -3.66355  -7.17797  34.25911  1.000 13.50441 ? 172 ALA   B C   1 
ATOM   4180 O O   . ALA   B 1 193 ? -3.84279  -8.39381  34.40268  1.000 12.63094 ? 172 ALA   B O   1 
ATOM   4181 C CB  . ALA   B 1 193 ? -5.13653  -6.16712  32.49943  1.000 10.72818 ? 172 ALA   B CB  1 
ATOM   4182 N N   . LEU   B 1 194 ? -2.45028  -6.62359  34.32746  1.000 11.36271 ? 173 LEU   B N   1 
ATOM   4183 C CA  . LEU   B 1 194 ? -1.27101  -7.43373  34.60400  1.000 11.57421 ? 173 LEU   B CA  1 
ATOM   4184 C C   . LEU   B 1 194 ? -1.28901  -8.01190  36.01259  1.000 14.37160 ? 173 LEU   B C   1 
ATOM   4185 O O   . LEU   B 1 194 ? -0.65895  -9.04753  36.25093  1.000 8.83782  ? 173 LEU   B O   1 
ATOM   4186 C CB  . LEU   B 1 194 ? -0.00474  -6.60207  34.39420  1.000 14.48286 ? 173 LEU   B CB  1 
ATOM   4187 C CG  . LEU   B 1 194 ? 0.19386   -6.03745  32.98265  1.000 20.87674 ? 173 LEU   B CG  1 
ATOM   4188 C CD1 . LEU   B 1 194 ? 1.56973   -5.40629  32.83432  1.000 16.99538 ? 173 LEU   B CD1 1 
ATOM   4189 C CD2 . LEU   B 1 194 ? -0.03039  -7.10572  31.92250  1.000 18.40413 ? 173 LEU   B CD2 1 
ATOM   4190 N N   . TRP   B 1 195 ? -2.00341  -7.37390  36.94087  1.000 12.08857 ? 174 TRP   B N   1 
ATOM   4191 C CA  . TRP   B 1 195 ? -2.13427  -7.85728  38.30954  1.000 13.02455 ? 174 TRP   B CA  1 
ATOM   4192 C C   . TRP   B 1 195 ? -3.20928  -8.92572  38.45303  1.000 18.92614 ? 174 TRP   B C   1 
ATOM   4193 O O   . TRP   B 1 195 ? -3.42199  -9.42097  39.56509  1.000 16.94803 ? 174 TRP   B O   1 
ATOM   4194 C CB  . TRP   B 1 195 ? -2.44726  -6.69209  39.25758  1.000 11.06406 ? 174 TRP   B CB  1 
ATOM   4195 C CG  . TRP   B 1 195 ? -1.29576  -5.75399  39.47354  1.000 9.34623  ? 174 TRP   B CG  1 
ATOM   4196 C CD1 . TRP   B 1 195 ? -0.64990  -5.02142  38.52211  1.000 11.69213 ? 174 TRP   B CD1 1 
ATOM   4197 C CD2 . TRP   B 1 195 ? -0.65669  -5.44416  40.71981  1.000 11.10914 ? 174 TRP   B CD2 1 
ATOM   4198 N NE1 . TRP   B 1 195 ? 0.35367   -4.27790  39.09478  1.000 9.55846  ? 174 TRP   B NE1 1 
ATOM   4199 C CE2 . TRP   B 1 195 ? 0.37018   -4.51822  40.44315  1.000 10.52010 ? 174 TRP   B CE2 1 
ATOM   4200 C CE3 . TRP   B 1 195 ? -0.84996  -5.86149  42.04027  1.000 10.76948 ? 174 TRP   B CE3 1 
ATOM   4201 C CZ2 . TRP   B 1 195 ? 1.20106   -4.00319  41.43768  1.000 13.05379 ? 174 TRP   B CZ2 1 
ATOM   4202 C CZ3 . TRP   B 1 195 ? -0.02470  -5.34589  43.02764  1.000 12.93334 ? 174 TRP   B CZ3 1 
ATOM   4203 C CH2 . TRP   B 1 195 ? 0.98705   -4.42608  42.72023  1.000 10.59280 ? 174 TRP   B CH2 1 
ATOM   4204 N N   . GLN   B 1 196 ? -3.89046  -9.28521  37.36560  1.000 14.20965 ? 175 GLN   B N   1 
ATOM   4205 C CA  . GLN   B 1 196 ? -4.98432  -10.24552 37.39394  1.000 13.86623 ? 175 GLN   B CA  1 
ATOM   4206 C C   . GLN   B 1 196 ? -4.52545  -11.67933 37.15765  1.000 21.22847 ? 175 GLN   B C   1 
ATOM   4207 O O   . GLN   B 1 196 ? -5.36839  -12.55451 36.93508  1.000 19.14025 ? 175 GLN   B O   1 
ATOM   4208 C CB  . GLN   B 1 196 ? -6.04420  -9.87064  36.35334  1.000 16.97166 ? 175 GLN   B CB  1 
ATOM   4209 C CG  . GLN   B 1 196 ? -6.55986  -8.44418  36.46526  1.000 12.01313 ? 175 GLN   B CG  1 
ATOM   4210 C CD  . GLN   B 1 196 ? -7.02165  -8.10392  37.86561  1.000 17.13080 ? 175 GLN   B CD  1 
ATOM   4211 O OE1 . GLN   B 1 196 ? -8.01258  -8.64791  38.35343  1.000 16.27897 ? 175 GLN   B OE1 1 
ATOM   4212 N NE2 . GLN   B 1 196 ? -6.30124  -7.20437  38.52396  1.000 15.64169 ? 175 GLN   B NE2 1 
ATOM   4213 N N   . GLY   B 1 197 ? -3.22021  -11.94011 37.19340  1.000 14.96886 ? 176 GLY   B N   1 
ATOM   4214 C CA  . GLY   B 1 197 ? -2.72997  -13.29594 37.04182  1.000 11.92004 ? 176 GLY   B CA  1 
ATOM   4215 C C   . GLY   B 1 197 ? -1.40861  -13.41653 36.31260  1.000 16.19420 ? 176 GLY   B C   1 
ATOM   4216 O O   . GLY   B 1 197 ? -0.64415  -14.35282 36.56446  1.000 18.69814 ? 176 GLY   B O   1 
ATOM   4217 N N   . SER   B 1 198 ? -1.12149  -12.47572 35.41042  1.000 14.72055 ? 177 SER   B N   1 
ATOM   4218 C CA  . SER   B 1 198 ? 0.10358   -12.56237 34.62213  1.000 12.35332 ? 177 SER   B CA  1 
ATOM   4219 C C   . SER   B 1 198 ? 1.33769   -12.33931 35.48664  1.000 12.89796 ? 177 SER   B C   1 
ATOM   4220 O O   . SER   B 1 198 ? 2.29455   -13.12173 35.43528  1.000 12.88926 ? 177 SER   B O   1 
ATOM   4221 C CB  . SER   B 1 198 ? 0.05896   -11.55248 33.47649  1.000 17.03243 ? 177 SER   B CB  1 
ATOM   4222 O OG  . SER   B 1 198 ? -1.01161  -11.83686 32.59172  1.000 19.69422 ? 177 SER   B OG  1 
ATOM   4223 N N   . LEU   B 1 199 ? 1.33595   -11.27248 36.28750  1.000 9.61199  ? 178 LEU   B N   1 
ATOM   4224 C CA  . LEU   B 1 199 ? 2.48430   -10.99369 37.14301  1.000 14.14260 ? 178 LEU   B CA  1 
ATOM   4225 C C   . LEU   B 1 199 ? 2.65962   -12.08029 38.19762  1.000 12.11439 ? 178 LEU   B C   1 
ATOM   4226 O O   . LEU   B 1 199 ? 3.78970   -12.48152 38.49973  1.000 14.95624 ? 178 LEU   B O   1 
ATOM   4227 C CB  . LEU   B 1 199 ? 2.32879   -9.61909  37.79643  1.000 15.60065 ? 178 LEU   B CB  1 
ATOM   4228 C CG  . LEU   B 1 199 ? 2.75799   -8.42961  36.92821  1.000 14.01261 ? 178 LEU   B CG  1 
ATOM   4229 C CD1 . LEU   B 1 199 ? 2.22124   -7.11500  37.49259  1.000 11.12981 ? 178 LEU   B CD1 1 
ATOM   4230 C CD2 . LEU   B 1 199 ? 4.27163   -8.37846  36.77043  1.000 11.91619 ? 178 LEU   B CD2 1 
ATOM   4231 N N   . GLN   B 1 200 ? 1.55091   -12.57489 38.75631  1.000 12.01342 ? 179 GLN   B N   1 
ATOM   4232 C CA  . GLN   B 1 200 ? 1.62167   -13.60512 39.78950  1.000 15.38184 ? 179 GLN   B CA  1 
ATOM   4233 C C   . GLN   B 1 200 ? 2.25203   -14.88468 39.25604  1.000 14.73134 ? 179 GLN   B C   1 
ATOM   4234 O O   . GLN   B 1 200 ? 3.18384   -15.43075 39.85879  1.000 14.57579 ? 179 GLN   B O   1 
ATOM   4235 C CB  . GLN   B 1 200 ? 0.22367   -13.89406 40.33984  1.000 13.19563 ? 179 GLN   B CB  1 
ATOM   4236 C CG  . GLN   B 1 200 ? -0.48597  -12.68451 40.90290  1.000 23.57236 ? 179 GLN   B CG  1 
ATOM   4237 C CD  . GLN   B 1 200 ? -1.36042  -11.99173 39.87778  1.000 21.48275 ? 179 GLN   B CD  1 
ATOM   4238 O OE1 . GLN   B 1 200 ? -0.86981  -11.49210 38.86561  1.000 15.63369 ? 179 GLN   B OE1 1 
ATOM   4239 N NE2 . GLN   B 1 200 ? -2.66293  -11.95226 40.13769  1.000 22.32308 ? 179 GLN   B NE2 1 
ATOM   4240 N N   . ALA   B 1 201 ? 1.75217   -15.37898 38.12180  1.000 13.21934 ? 180 ALA   B N   1 
ATOM   4241 C CA  . ALA   B 1 201 ? 2.25549   -16.63519 37.57807  1.000 18.56902 ? 180 ALA   B CA  1 
ATOM   4242 C C   . ALA   B 1 201 ? 3.72346   -16.52478 37.19559  1.000 20.37888 ? 180 ALA   B C   1 
ATOM   4243 O O   . ALA   B 1 201 ? 4.50902   -17.44618 37.44528  1.000 20.05925 ? 180 ALA   B O   1 
ATOM   4244 C CB  . ALA   B 1 201 ? 1.42002   -17.05772 36.36995  1.000 20.91091 ? 180 ALA   B CB  1 
ATOM   4245 N N   . ASN   B 1 202 ? 4.11421   -15.40412 36.58786  1.000 17.55243 ? 181 ASN   B N   1 
ATOM   4246 C CA  . ASN   B 1 202 ? 5.47768   -15.28525 36.08478  1.000 14.52056 ? 181 ASN   B CA  1 
ATOM   4247 C C   . ASN   B 1 202 ? 6.48400   -15.11026 37.21532  1.000 14.02682 ? 181 ASN   B C   1 
ATOM   4248 O O   . ASN   B 1 202 ? 7.53597   -15.76075 37.22055  1.000 10.98138 ? 181 ASN   B O   1 
ATOM   4249 C CB  . ASN   B 1 202 ? 5.56713   -14.12910 35.09299  1.000 16.97484 ? 181 ASN   B CB  1 
ATOM   4250 C CG  . ASN   B 1 202 ? 6.70782   -14.29709 34.11996  1.000 17.80317 ? 181 ASN   B CG  1 
ATOM   4251 O OD1 . ASN   B 1 202 ? 6.79856   -15.31213 33.42846  1.000 20.41769 ? 181 ASN   B OD1 1 
ATOM   4252 N ND2 . ASN   B 1 202 ? 7.58466   -13.30260 34.05483  1.000 16.61565 ? 181 ASN   B ND2 1 
ATOM   4253 N N   . LEU   B 1 203 ? 6.17922   -14.24544 38.18556  1.000 17.41094 ? 182 LEU   B N   1 
ATOM   4254 C CA  . LEU   B 1 203 ? 7.10271   -14.03526 39.29648  1.000 11.88607 ? 182 LEU   B CA  1 
ATOM   4255 C C   . LEU   B 1 203 ? 7.30089   -15.32098 40.08974  1.000 18.98311 ? 182 LEU   B C   1 
ATOM   4256 O O   . LEU   B 1 203 ? 8.41293   -15.61517 40.54502  1.000 20.58508 ? 182 LEU   B O   1 
ATOM   4257 C CB  . LEU   B 1 203 ? 6.59020   -12.91127 40.19911  1.000 14.22109 ? 182 LEU   B CB  1 
ATOM   4258 C CG  . LEU   B 1 203 ? 6.86458   -11.47987 39.72991  1.000 7.47276  ? 182 LEU   B CG  1 
ATOM   4259 C CD1 . LEU   B 1 203 ? 6.01457   -10.48344 40.49948  1.000 13.41416 ? 182 LEU   B CD1 1 
ATOM   4260 C CD2 . LEU   B 1 203 ? 8.33649   -11.13626 39.86712  1.000 9.33029  ? 182 LEU   B CD2 1 
ATOM   4261 N N   . THR   B 1 204 ? 6.23258   -16.10470 40.25401  1.000 16.79602 ? 183 THR   B N   1 
ATOM   4262 C CA  . THR   B 1 204 ? 6.33450   -17.37498 40.96616  1.000 13.31818 ? 183 THR   B CA  1 
ATOM   4263 C C   . THR   B 1 204 ? 7.25744   -18.34224 40.23360  1.000 14.69617 ? 183 THR   B C   1 
ATOM   4264 O O   . THR   B 1 204 ? 8.14865   -18.95051 40.83780  1.000 18.93945 ? 183 THR   B O   1 
ATOM   4265 C CB  . THR   B 1 204 ? 4.94230   -17.98743 41.13221  1.000 12.28030 ? 183 THR   B CB  1 
ATOM   4266 O OG1 . THR   B 1 204 ? 4.14531   -17.14610 41.97323  1.000 17.64337 ? 183 THR   B OG1 1 
ATOM   4267 C CG2 . THR   B 1 204 ? 5.03858   -19.37158 41.76017  1.000 18.08618 ? 183 THR   B CG2 1 
ATOM   4268 N N   . SER   B 1 205 ? 7.05679   -18.49417 38.92214  1.000 22.15220 ? 184 SER   B N   1 
ATOM   4269 C CA  . SER   B 1 205 ? 7.88354   -19.41342 38.14731  1.000 17.48379 ? 184 SER   B CA  1 
ATOM   4270 C C   . SER   B 1 205 ? 9.33849   -18.96264 38.12012  1.000 19.29658 ? 184 SER   B C   1 
ATOM   4271 O O   . SER   B 1 205 ? 10.25122  -19.77722 38.30094  1.000 16.57584 ? 184 SER   B O   1 
ATOM   4272 C CB  . SER   B 1 205 ? 7.33045   -19.53963 36.72787  1.000 21.84044 ? 184 SER   B CB  1 
ATOM   4273 O OG  . SER   B 1 205 ? 8.33842   -19.94140 35.81705  1.000 23.47292 ? 184 SER   B OG  1 
ATOM   4274 N N   . LEU   B 1 206 ? 9.57337   -17.66501 37.90785  1.000 15.22006 ? 185 LEU   B N   1 
ATOM   4275 C CA  . LEU   B 1 206 ? 10.94083  -17.16382 37.80892  1.000 13.13251 ? 185 LEU   B CA  1 
ATOM   4276 C C   . LEU   B 1 206 ? 11.69492  -17.33496 39.12160  1.000 17.70987 ? 185 LEU   B C   1 
ATOM   4277 O O   . LEU   B 1 206 ? 12.86469  -17.73766 39.12760  1.000 20.63418 ? 185 LEU   B O   1 
ATOM   4278 C CB  . LEU   B 1 206 ? 10.93081  -15.69326 37.39478  1.000 20.19668 ? 185 LEU   B CB  1 
ATOM   4279 C CG  . LEU   B 1 206 ? 10.55562  -15.36676 35.94806  1.000 15.99240 ? 185 LEU   B CG  1 
ATOM   4280 C CD1 . LEU   B 1 206 ? 10.33266  -13.87121 35.80083  1.000 16.42700 ? 185 LEU   B CD1 1 
ATOM   4281 C CD2 . LEU   B 1 206 ? 11.61822  -15.86122 34.97507  1.000 20.18210 ? 185 LEU   B CD2 1 
ATOM   4282 N N   . ILE   B 1 207 ? 11.04432  -17.02763 40.24431  1.000 14.30395 ? 186 ILE   B N   1 
ATOM   4283 C CA  . ILE   B 1 207 ? 11.71731  -17.10932 41.53634  1.000 19.36492 ? 186 ILE   B CA  1 
ATOM   4284 C C   . ILE   B 1 207 ? 12.01090  -18.56072 41.89650  1.000 17.18433 ? 186 ILE   B C   1 
ATOM   4285 O O   . ILE   B 1 207 ? 13.08503  -18.87974 42.41949  1.000 21.84849 ? 186 ILE   B O   1 
ATOM   4286 C CB  . ILE   B 1 207 ? 10.87457  -16.40644 42.61680  1.000 18.04100 ? 186 ILE   B CB  1 
ATOM   4287 C CG1 . ILE   B 1 207 ? 10.97208  -14.88800 42.45557  1.000 19.10082 ? 186 ILE   B CG1 1 
ATOM   4288 C CG2 . ILE   B 1 207 ? 11.32711  -16.81790 44.01033  1.000 21.04617 ? 186 ILE   B CG2 1 
ATOM   4289 C CD1 . ILE   B 1 207 ? 9.83370   -14.12918 43.09193  1.000 17.93712 ? 186 ILE   B CD1 1 
ATOM   4290 N N   . ARG   B 1 208 ? 11.07176  -19.46461 41.61186  1.000 18.14293 ? 187 ARG   B N   1 
ATOM   4291 C CA  . ARG   B 1 208 ? 11.27088  -20.86651 41.96393  1.000 21.78908 ? 187 ARG   B CA  1 
ATOM   4292 C C   . ARG   B 1 208 ? 12.30800  -21.53509 41.06930  1.000 24.88299 ? 187 ARG   B C   1 
ATOM   4293 O O   . ARG   B 1 208 ? 12.98022  -22.47840 41.50198  1.000 23.39900 ? 187 ARG   B O   1 
ATOM   4294 C CB  . ARG   B 1 208 ? 9.93885   -21.61353 41.90624  1.000 18.56762 ? 187 ARG   B CB  1 
ATOM   4295 C CG  . ARG   B 1 208 ? 9.04900   -21.31865 43.10290  1.000 20.48603 ? 187 ARG   B CG  1 
ATOM   4296 C CD  . ARG   B 1 208 ? 7.68638   -21.97533 42.99596  1.000 23.58513 ? 187 ARG   B CD  1 
ATOM   4297 N NE  . ARG   B 1 208 ? 6.85217   -21.62772 44.14002  1.000 21.92252 ? 187 ARG   B NE  1 
ATOM   4298 C CZ  . ARG   B 1 208 ? 5.55023   -21.86329 44.22459  1.000 26.39766 ? 187 ARG   B CZ  1 
ATOM   4299 N NH1 . ARG   B 1 208 ? 4.88809   -22.45070 43.24148  1.000 26.06304 ? 187 ARG   B NH1 1 
ATOM   4300 N NH2 . ARG   B 1 208 ? 4.89646   -21.50067 45.32469  1.000 23.74060 ? 187 ARG   B NH2 1 
ATOM   4301 N N   . ARG   B 1 209 ? 12.45256  -21.07294 39.82914  1.000 19.49853 ? 188 ARG   B N   1 
ATOM   4302 C CA  . ARG   B 1 209 ? 13.51517  -21.55594 38.95953  1.000 24.17706 ? 188 ARG   B CA  1 
ATOM   4303 C C   . ARG   B 1 209 ? 14.82273  -20.79659 39.14810  1.000 24.76408 ? 188 ARG   B C   1 
ATOM   4304 O O   . ARG   B 1 209 ? 15.84961  -21.21670 38.60330  1.000 26.91536 ? 188 ARG   B O   1 
ATOM   4305 C CB  . ARG   B 1 209 ? 13.07534  -21.47283 37.49351  1.000 24.56767 ? 188 ARG   B CB  1 
ATOM   4306 C CG  . ARG   B 1 209 ? 12.03083  -22.51238 37.10849  1.000 27.82815 ? 188 ARG   B CG  1 
ATOM   4307 C CD  . ARG   B 1 209 ? 11.70588  -22.47138 35.62240  1.000 28.35542 ? 188 ARG   B CD  1 
ATOM   4308 N NE  . ARG   B 1 209 ? 11.11833  -21.20091 35.21457  1.000 32.18531 ? 188 ARG   B NE  1 
ATOM   4309 C CZ  . ARG   B 1 209 ? 11.68710  -20.34692 34.37401  1.000 27.46220 ? 188 ARG   B CZ  1 
ATOM   4310 N NH1 . ARG   B 1 209 ? 12.86657  -20.59502 33.82920  1.000 32.18934 ? 188 ARG   B NH1 1 
ATOM   4311 N NH2 . ARG   B 1 209 ? 11.05395  -19.21758 34.06844  1.000 26.18836 ? 188 ARG   B NH2 1 
ATOM   4312 N N   . LEU   B 1 210 ? 14.80759  -19.70369 39.91102  1.000 16.57677 ? 189 LEU   B N   1 
ATOM   4313 C CA  . LEU   B 1 210 ? 16.02095  -18.91665 40.11858  1.000 25.07319 ? 189 LEU   B CA  1 
ATOM   4314 C C   . LEU   B 1 210 ? 17.18336  -19.70355 40.71847  1.000 28.32648 ? 189 LEU   B C   1 
ATOM   4315 O O   . LEU   B 1 210 ? 18.32088  -19.50378 40.25599  1.000 25.25481 ? 189 LEU   B O   1 
ATOM   4316 C CB  . LEU   B 1 210 ? 15.69804  -17.69421 40.98888  1.000 18.15843 ? 189 LEU   B CB  1 
ATOM   4317 C CG  . LEU   B 1 210 ? 16.88101  -16.78844 41.33911  1.000 21.53173 ? 189 LEU   B CG  1 
ATOM   4318 C CD1 . LEU   B 1 210 ? 17.41174  -16.08814 40.09580  1.000 23.75009 ? 189 LEU   B CD1 1 
ATOM   4319 C CD2 . LEU   B 1 210 ? 16.49002  -15.77542 42.40306  1.000 22.02928 ? 189 LEU   B CD2 1 
ATOM   4320 N N   . PRO   B 1 211 ? 17.00026  -20.56847 41.72692  1.000 28.19757 ? 190 PRO   B N   1 
ATOM   4321 C CA  . PRO   B 1 211 ? 18.16913  -21.25808 42.30079  1.000 24.87314 ? 190 PRO   B CA  1 
ATOM   4322 C C   . PRO   B 1 211 ? 18.96282  -22.07348 41.29489  1.000 27.12876 ? 190 PRO   B C   1 
ATOM   4323 O O   . PRO   B 1 211 ? 20.17820  -22.23091 41.46818  1.000 29.35998 ? 190 PRO   B O   1 
ATOM   4324 C CB  . PRO   B 1 211 ? 17.54615  -22.15121 43.38152  1.000 29.77064 ? 190 PRO   B CB  1 
ATOM   4325 C CG  . PRO   B 1 211 ? 16.32604  -21.42163 43.78987  1.000 24.69741 ? 190 PRO   B CG  1 
ATOM   4326 C CD  . PRO   B 1 211 ? 15.78274  -20.85098 42.51154  1.000 27.18450 ? 190 PRO   B CD  1 
ATOM   4327 N N   . GLU   B 1 212 ? 18.32206  -22.59475 40.24792  1.000 24.39604 ? 191 GLU   B N   1 
ATOM   4328 C CA  . GLU   B 1 212 ? 19.01787  -23.43384 39.28076  1.000 33.47774 ? 191 GLU   B CA  1 
ATOM   4329 C C   . GLU   B 1 212 ? 19.70111  -22.64406 38.17117  1.000 42.58250 ? 191 GLU   B C   1 
ATOM   4330 O O   . GLU   B 1 212 ? 20.55812  -23.20155 37.47559  1.000 41.17424 ? 191 GLU   B O   1 
ATOM   4331 C CB  . GLU   B 1 212 ? 18.04930  -24.44812 38.66333  1.000 37.79644 ? 191 GLU   B CB  1 
ATOM   4332 C CG  . GLU   B 1 212 ? 18.05803  -25.81251 39.34772  1.000 35.28573 ? 191 GLU   B CG  1 
ATOM   4333 C CD  . GLU   B 1 212 ? 19.41191  -26.17612 39.94043  1.000 52.62554 ? 191 GLU   B CD  1 
ATOM   4334 O OE1 . GLU   B 1 212 ? 20.40293  -26.24944 39.18010  1.000 47.67850 ? 191 GLU   B OE1 1 
ATOM   4335 O OE2 . GLU   B 1 212 ? 19.48616  -26.38429 41.17047  1.000 46.65684 ? 191 GLU   B OE2 1 
ATOM   4336 N N   . ASN   B 1 213 ? 19.34739  -21.37343 37.97951  1.000 35.00369 ? 192 ASN   B N   1 
ATOM   4337 C CA  . ASN   B 1 213 ? 20.10814  -20.53178 37.06296  1.000 38.14718 ? 192 ASN   B CA  1 
ATOM   4338 C C   . ASN   B 1 213 ? 19.96752  -19.06639 37.45862  1.000 33.78031 ? 192 ASN   B C   1 
ATOM   4339 O O   . ASN   B 1 213 ? 18.86294  -18.50780 37.42863  1.000 35.60810 ? 192 ASN   B O   1 
ATOM   4340 C CB  . ASN   B 1 213 ? 19.67799  -20.75754 35.60918  1.000 37.71513 ? 192 ASN   B CB  1 
ATOM   4341 C CG  . ASN   B 1 213 ? 18.20149  -20.52480 35.38650  1.000 37.25853 ? 192 ASN   B CG  1 
ATOM   4342 O OD1 . ASN   B 1 213 ? 17.36952  -20.90004 36.21259  1.000 35.31239 ? 192 ASN   B OD1 1 
ATOM   4343 N ND2 . ASN   B 1 213 ? 17.86483  -19.91203 34.25367  1.000 24.17420 ? 192 ASN   B ND2 1 
ATOM   4344 N N   . PRO   B 1 214 ? 21.06919  -18.41627 37.84519  1.000 36.78100 ? 193 PRO   B N   1 
ATOM   4345 C CA  . PRO   B 1 214 ? 20.98732  -17.02262 38.30830  1.000 27.14549 ? 193 PRO   B CA  1 
ATOM   4346 C C   . PRO   B 1 214 ? 20.64317  -16.02423 37.21694  1.000 29.23911 ? 193 PRO   B C   1 
ATOM   4347 O O   . PRO   B 1 214 ? 20.40153  -14.85373 37.53784  1.000 30.23665 ? 193 PRO   B O   1 
ATOM   4348 C CB  . PRO   B 1 214 ? 22.39326  -16.75795 38.86668  1.000 33.93693 ? 193 PRO   B CB  1 
ATOM   4349 C CG  . PRO   B 1 214 ? 22.95299  -18.12216 39.15251  1.000 31.93727 ? 193 PRO   B CG  1 
ATOM   4350 C CD  . PRO   B 1 214 ? 22.40915  -18.98476 38.05795  1.000 30.65549 ? 193 PRO   B CD  1 
ATOM   4351 N N   . SER   B 1 215 ? 20.62008  -16.43388 35.94605  1.000 28.66089 ? 194 SER   B N   1 
ATOM   4352 C CA  . SER   B 1 215 ? 20.32417  -15.49948 34.86660  1.000 29.47907 ? 194 SER   B CA  1 
ATOM   4353 C C   . SER   B 1 215 ? 18.89938  -14.96764 34.92183  1.000 30.44363 ? 194 SER   B C   1 
ATOM   4354 O O   . SER   B 1 215 ? 18.59580  -13.99286 34.22624  1.000 29.96268 ? 194 SER   B O   1 
ATOM   4355 C CB  . SER   B 1 215 ? 20.56523  -16.15874 33.50763  1.000 27.11301 ? 194 SER   B CB  1 
ATOM   4356 O OG  . SER   B 1 215 ? 19.54875  -17.10021 33.21078  1.000 31.92867 ? 194 SER   B OG  1 
ATOM   4357 N N   . LEU   B 1 216 ? 18.02366  -15.58153 35.71824  1.000 24.26502 ? 195 LEU   B N   1 
ATOM   4358 C CA  . LEU   B 1 216 ? 16.64053  -15.13841 35.82346  1.000 21.96315 ? 195 LEU   B CA  1 
ATOM   4359 C C   . LEU   B 1 216 ? 16.46270  -13.96598 36.77791  1.000 20.94795 ? 195 LEU   B C   1 
ATOM   4360 O O   . LEU   B 1 216 ? 15.34809  -13.44291 36.87986  1.000 22.04702 ? 195 LEU   B O   1 
ATOM   4361 C CB  . LEU   B 1 216 ? 15.74749  -16.29928 36.27062  1.000 16.56234 ? 195 LEU   B CB  1 
ATOM   4362 C CG  . LEU   B 1 216 ? 15.64855  -17.48680 35.30919  1.000 24.09041 ? 195 LEU   B CG  1 
ATOM   4363 C CD1 . LEU   B 1 216 ? 14.81536  -18.60722 35.91339  1.000 27.67502 ? 195 LEU   B CD1 1 
ATOM   4364 C CD2 . LEU   B 1 216 ? 15.07505  -17.05498 33.96786  1.000 27.84345 ? 195 LEU   B CD2 1 
ATOM   4365 N N   . TYR   B 1 217 ? 17.52277  -13.54271 37.47311  1.000 19.74525 ? 196 TYR   B N   1 
ATOM   4366 C CA  . TYR   B 1 217 ? 17.39313  -12.45301 38.43699  1.000 26.40742 ? 196 TYR   B CA  1 
ATOM   4367 C C   . TYR   B 1 217 ? 16.92647  -11.16974 37.75926  1.000 18.74958 ? 196 TYR   B C   1 
ATOM   4368 O O   . TYR   B 1 217 ? 16.01962  -10.48791 38.25087  1.000 20.99269 ? 196 TYR   B O   1 
ATOM   4369 C CB  . TYR   B 1 217 ? 18.72325  -12.22808 39.15819  1.000 25.92655 ? 196 TYR   B CB  1 
ATOM   4370 C CG  . TYR   B 1 217 ? 18.64154  -11.22780 40.29130  1.000 20.86794 ? 196 TYR   B CG  1 
ATOM   4371 C CD1 . TYR   B 1 217 ? 18.29738  -11.62948 41.57500  1.000 23.32694 ? 196 TYR   B CD1 1 
ATOM   4372 C CD2 . TYR   B 1 217 ? 18.90348  -9.88001  40.07541  1.000 21.55084 ? 196 TYR   B CD2 1 
ATOM   4373 C CE1 . TYR   B 1 217 ? 18.21815  -10.71770 42.61281  1.000 26.79453 ? 196 TYR   B CE1 1 
ATOM   4374 C CE2 . TYR   B 1 217 ? 18.82511  -8.96157  41.10626  1.000 26.36417 ? 196 TYR   B CE2 1 
ATOM   4375 C CZ  . TYR   B 1 217 ? 18.48318  -9.38579  42.37260  1.000 23.62448 ? 196 TYR   B CZ  1 
ATOM   4376 O OH  . TYR   B 1 217 ? 18.40802  -8.47348  43.40034  1.000 26.83069 ? 196 TYR   B OH  1 
ATOM   4377 N N   . SER   B 1 218 ? 17.53233  -10.82836 36.62022  1.000 22.90379 ? 197 SER   B N   1 
ATOM   4378 C CA  . SER   B 1 218 ? 17.12514  -9.62542  35.90315  1.000 16.65599 ? 197 SER   B CA  1 
ATOM   4379 C C   . SER   B 1 218 ? 15.68685  -9.72653  35.41150  1.000 21.17193 ? 197 SER   B C   1 
ATOM   4380 O O   . SER   B 1 218 ? 15.01219  -8.70172  35.25379  1.000 21.57363 ? 197 SER   B O   1 
ATOM   4381 C CB  . SER   B 1 218 ? 18.07447  -9.36775  34.73227  1.000 20.28371 ? 197 SER   B CB  1 
ATOM   4382 O OG  . SER   B 1 218 ? 17.99265  -10.40673 33.77072  1.000 25.57691 ? 197 SER   B OG  1 
ATOM   4383 N N   . GLU   B 1 219 ? 15.20165  -10.94615 35.16146  1.000 18.32544 ? 198 GLU   B N   1 
ATOM   4384 C CA  . GLU   B 1 219 ? 13.81781  -11.11474 34.72839  1.000 16.57621 ? 198 GLU   B CA  1 
ATOM   4385 C C   . GLU   B 1 219 ? 12.84595  -10.82808 35.86616  1.000 17.63932 ? 198 GLU   B C   1 
ATOM   4386 O O   . GLU   B 1 219 ? 11.80260  -10.19858 35.65449  1.000 12.74519 ? 198 GLU   B O   1 
ATOM   4387 C CB  . GLU   B 1 219 ? 13.60373  -12.52656 34.18185  1.000 20.78449 ? 198 GLU   B CB  1 
ATOM   4388 C CG  . GLU   B 1 219 ? 14.62273  -12.95462 33.13190  1.000 29.89445 ? 198 GLU   B CG  1 
ATOM   4389 C CD  . GLU   B 1 219 ? 14.41372  -12.28362 31.78721  1.000 28.74943 ? 198 GLU   B CD  1 
ATOM   4390 O OE1 . GLU   B 1 219 ? 13.34375  -11.67342 31.57406  1.000 26.83641 ? 198 GLU   B OE1 1 
ATOM   4391 O OE2 . GLU   B 1 219 ? 15.32939  -12.36256 30.94188  1.000 30.78625 ? 198 GLU   B OE2 1 
ATOM   4392 N N   . ILE   B 1 220 ? 13.17055  -11.28458 37.07907  1.000 13.26341 ? 199 ILE   B N   1 
ATOM   4393 C CA  . ILE   B 1 220 ? 12.33200  -10.99059 38.23829  1.000 19.34749 ? 199 ILE   B CA  1 
ATOM   4394 C C   . ILE   B 1 220 ? 12.30098  -9.49222  38.50365  1.000 13.90591 ? 199 ILE   B C   1 
ATOM   4395 O O   . ILE   B 1 220 ? 11.24525  -8.92104  38.80372  1.000 15.09101 ? 199 ILE   B O   1 
ATOM   4396 C CB  . ILE   B 1 220 ? 12.82568  -11.77089 39.47097  1.000 16.84551 ? 199 ILE   B CB  1 
ATOM   4397 C CG1 . ILE   B 1 220 ? 12.83294  -13.27153 39.18580  1.000 16.69944 ? 199 ILE   B CG1 1 
ATOM   4398 C CG2 . ILE   B 1 220 ? 11.95602  -11.46816 40.68042  1.000 16.76448 ? 199 ILE   B CG2 1 
ATOM   4399 C CD1 . ILE   B 1 220 ? 13.75886  -14.05474 40.09505  1.000 19.78822 ? 199 ILE   B CD1 1 
ATOM   4400 N N   . ILE   B 1 221 ? 13.45510  -8.83128  38.39021  1.000 11.97556 ? 200 ILE   B N   1 
ATOM   4401 C CA  . ILE   B 1 221 ? 13.51830  -7.39275  38.63283  1.000 15.24779 ? 200 ILE   B CA  1 
ATOM   4402 C C   . ILE   B 1 221 ? 12.64284  -6.64090  37.63617  1.000 12.56774 ? 200 ILE   B C   1 
ATOM   4403 O O   . ILE   B 1 221 ? 11.94377  -5.68672  37.99886  1.000 12.56864 ? 200 ILE   B O   1 
ATOM   4404 C CB  . ILE   B 1 221 ? 14.97991  -6.90813  38.59152  1.000 15.39724 ? 200 ILE   B CB  1 
ATOM   4405 C CG1 . ILE   B 1 221 ? 15.75783  -7.42830  39.80630  1.000 18.64953 ? 200 ILE   B CG1 1 
ATOM   4406 C CG2 . ILE   B 1 221 ? 15.04370  -5.38823  38.52628  1.000 17.82824 ? 200 ILE   B CG2 1 
ATOM   4407 C CD1 . ILE   B 1 221 ? 14.96235  -7.44523  41.10378  1.000 14.92082 ? 200 ILE   B CD1 1 
ATOM   4408 N N   . MET   B 1 222 ? 12.65717  -7.05811  36.36892  1.000 11.88756 ? 201 MET   B N   1 
ATOM   4409 C CA  . MET   B 1 222 ? 11.85627  -6.35724  35.36913  1.000 15.55233 ? 201 MET   B CA  1 
ATOM   4410 C C   . MET   B 1 222 ? 10.36571  -6.47873  35.67448  1.000 15.49480 ? 201 MET   B C   1 
ATOM   4411 O O   . MET   B 1 222 ? 9.61927   -5.49892  35.55749  1.000 13.62248 ? 201 MET   B O   1 
ATOM   4412 C CB  . MET   B 1 222 ? 12.18731  -6.87846  33.96727  1.000 11.89252 ? 201 MET   B CB  1 
ATOM   4413 C CG  . MET   B 1 222 ? 11.44971  -6.15271  32.83969  1.000 16.86160 ? 201 MET   B CG  1 
ATOM   4414 S SD  . MET   B 1 222 ? 11.78216  -6.79789  31.18243  1.000 18.02747 ? 201 MET   B SD  1 
ATOM   4415 C CE  . MET   B 1 222 ? 10.87941  -8.33602  31.19680  1.000 11.14382 ? 201 MET   B CE  1 
ATOM   4416 N N   . ASP   B 1 223 ? 9.91878   -7.66449  36.09981  1.000 13.82729 ? 202 ASP   B N   1 
ATOM   4417 C CA  . ASP   B 1 223 ? 8.52010   -7.83207  36.48406  1.000 10.59612 ? 202 ASP   B CA  1 
ATOM   4418 C C   . ASP   B 1 223 ? 8.16963   -7.01760  37.72339  1.000 14.23099 ? 202 ASP   B C   1 
ATOM   4419 O O   . ASP   B 1 223 ? 7.04034   -6.52837  37.84193  1.000 11.39617 ? 202 ASP   B O   1 
ATOM   4420 C CB  . ASP   B 1 223 ? 8.20988   -9.30928  36.71876  1.000 11.92282 ? 202 ASP   B CB  1 
ATOM   4421 C CG  . ASP   B 1 223 ? 7.93357   -10.05717 35.43067  1.000 16.78582 ? 202 ASP   B CG  1 
ATOM   4422 O OD1 . ASP   B 1 223 ? 8.42873   -9.61975  34.37109  1.000 17.21997 ? 202 ASP   B OD1 1 
ATOM   4423 O OD2 . ASP   B 1 223 ? 7.22467   -11.08341 35.47896  1.000 17.59084 ? 202 ASP   B OD2 1 
ATOM   4424 N N   . ILE   B 1 224 ? 9.10519   -6.88162  38.66500  1.000 13.59685 ? 203 ILE   B N   1 
ATOM   4425 C CA  . ILE   B 1 224 ? 8.85773   -6.03632  39.82893  1.000 11.20442 ? 203 ILE   B CA  1 
ATOM   4426 C C   . ILE   B 1 224 ? 8.75590   -4.57289  39.41485  1.000 12.91582 ? 203 ILE   B C   1 
ATOM   4427 O O   . ILE   B 1 224 ? 7.90079   -3.83150  39.91469  1.000 8.37763  ? 203 ILE   B O   1 
ATOM   4428 C CB  . ILE   B 1 224 ? 9.94649   -6.25758  40.89514  1.000 9.46460  ? 203 ILE   B CB  1 
ATOM   4429 C CG1 . ILE   B 1 224 ? 9.83955   -7.67146  41.46965  1.000 11.21140 ? 203 ILE   B CG1 1 
ATOM   4430 C CG2 . ILE   B 1 224 ? 9.84471   -5.21228  41.99549  1.000 12.06292 ? 203 ILE   B CG2 1 
ATOM   4431 C CD1 . ILE   B 1 224 ? 10.93025  -8.01338  42.46905  1.000 22.38710 ? 203 ILE   B CD1 1 
ATOM   4432 N N   . ILE   B 1 225 ? 9.62017   -4.13317  38.49588  1.000 9.75878  ? 204 ILE   B N   1 
ATOM   4433 C CA  . ILE   B 1 225 ? 9.54446   -2.75914  38.00560  1.000 9.43762  ? 204 ILE   B CA  1 
ATOM   4434 C C   . ILE   B 1 225 ? 8.21516   -2.52097  37.30362  1.000 10.12416 ? 204 ILE   B C   1 
ATOM   4435 O O   . ILE   B 1 225 ? 7.58260   -1.47278  37.47921  1.000 5.93435  ? 204 ILE   B O   1 
ATOM   4436 C CB  . ILE   B 1 225 ? 10.73781  -2.44813  37.08323  1.000 14.42349 ? 204 ILE   B CB  1 
ATOM   4437 C CG1 . ILE   B 1 225 ? 12.03508  -2.39615  37.89283  1.000 13.42064 ? 204 ILE   B CG1 1 
ATOM   4438 C CG2 . ILE   B 1 225 ? 10.51580  -1.13467  36.33682  1.000 8.44135  ? 204 ILE   B CG2 1 
ATOM   4439 C CD1 . ILE   B 1 225 ? 13.28569  -2.54341  37.05047  1.000 18.04932 ? 204 ILE   B CD1 1 
ATOM   4440 N N   . THR   B 1 226 ? 7.76738   -3.49219  36.50372  1.000 10.02751 ? 205 THR   B N   1 
ATOM   4441 C CA  . THR   B 1 226 ? 6.46587   -3.37277  35.85525  1.000 11.83268 ? 205 THR   B CA  1 
ATOM   4442 C C   . THR   B 1 226 ? 5.35357   -3.22718  36.88726  1.000 9.44595  ? 205 THR   B C   1 
ATOM   4443 O O   . THR   B 1 226 ? 4.48268   -2.35957  36.75508  1.000 7.46426  ? 205 THR   B O   1 
ATOM   4444 C CB  . THR   B 1 226 ? 6.22004   -4.58587  34.95658  1.000 11.92448 ? 205 THR   B CB  1 
ATOM   4445 O OG1 . THR   B 1 226 ? 7.04634   -4.48976  33.78992  1.000 11.81710 ? 205 THR   B OG1 1 
ATOM   4446 C CG2 . THR   B 1 226 ? 4.76251   -4.65630  34.53288  1.000 10.03912 ? 205 THR   B CG2 1 
ATOM   4447 N N   . ALA   B 1 227 ? 5.38794   -4.04377  37.94376  1.000 8.10612  ? 206 ALA   B N   1 
ATOM   4448 C CA  . ALA   B 1 227 ? 4.38917   -3.92869  39.00092  1.000 13.30324 ? 206 ALA   B CA  1 
ATOM   4449 C C   . ALA   B 1 227 ? 4.49198   -2.59698  39.73394  1.000 12.68224 ? 206 ALA   B C   1 
ATOM   4450 O O   . ALA   B 1 227 ? 3.49425   -2.11354  40.28091  1.000 13.06486 ? 206 ALA   B O   1 
ATOM   4451 C CB  . ALA   B 1 227 ? 4.53303   -5.08714  39.98780  1.000 13.50325 ? 206 ALA   B CB  1 
ATOM   4452 N N   . ALA   B 1 228 ? 5.68228   -1.99300  39.75464  1.000 9.93985  ? 207 ALA   B N   1 
ATOM   4453 C CA  . ALA   B 1 228 ? 5.88509   -0.74192  40.47476  1.000 8.80436  ? 207 ALA   B CA  1 
ATOM   4454 C C   . ALA   B 1 228 ? 5.42940   0.47390   39.68106  1.000 9.50073  ? 207 ALA   B C   1 
ATOM   4455 O O   . ALA   B 1 228 ? 5.07756   1.49893   40.27543  1.000 8.66234  ? 207 ALA   B O   1 
ATOM   4456 C CB  . ALA   B 1 228 ? 7.36217   -0.58245  40.83484  1.000 11.41772 ? 207 ALA   B CB  1 
ATOM   4457 N N   . LEU   B 1 229 ? 5.41579   0.37952   38.35265  1.000 7.63849  ? 208 LEU   B N   1 
ATOM   4458 C CA  . LEU   B 1 229 ? 5.40224   1.55766   37.49489  1.000 10.60497 ? 208 LEU   B CA  1 
ATOM   4459 C C   . LEU   B 1 229 ? 4.03967   1.86290   36.88078  1.000 8.58809  ? 208 LEU   B C   1 
ATOM   4460 O O   . LEU   B 1 229 ? 3.58701   3.00956   36.92666  1.000 7.39669  ? 208 LEU   B O   1 
ATOM   4461 C CB  . LEU   B 1 229 ? 6.44477   1.38089   36.38418  1.000 7.70757  ? 208 LEU   B CB  1 
ATOM   4462 C CG  . LEU   B 1 229 ? 6.64366   2.49955   35.36270  1.000 10.46985 ? 208 LEU   B CG  1 
ATOM   4463 C CD1 . LEU   B 1 229 ? 6.90985   3.83618   36.03954  1.000 12.42345 ? 208 LEU   B CD1 1 
ATOM   4464 C CD2 . LEU   B 1 229 ? 7.77991   2.13000   34.41942  1.000 14.20299 ? 208 LEU   B CD2 1 
ATOM   4465 N N   . PHE   B 1 230 ? 3.37148   0.87026   36.30759  1.000 10.20815 ? 209 PHE   B N   1 
ATOM   4466 C CA  . PHE   B 1 230 ? 2.28365   1.14672   35.38161  1.000 6.22933  ? 209 PHE   B CA  1 
ATOM   4467 C C   . PHE   B 1 230 ? 0.93439   1.19991   36.09028  1.000 9.18928  ? 209 PHE   B C   1 
ATOM   4468 O O   . PHE   B 1 230 ? 0.68929   0.48241   37.06447  1.000 10.41935 ? 209 PHE   B O   1 
ATOM   4469 C CB  . PHE   B 1 230 ? 2.27638   0.10391   34.26551  1.000 10.14179 ? 209 PHE   B CB  1 
ATOM   4470 C CG  . PHE   B 1 230 ? 3.48596   0.18173   33.37765  1.000 10.52796 ? 209 PHE   B CG  1 
ATOM   4471 C CD1 . PHE   B 1 230 ? 3.57069   1.13710   32.37845  1.000 11.14213 ? 209 PHE   B CD1 1 
ATOM   4472 C CD2 . PHE   B 1 230 ? 4.55723   -0.67555  33.57149  1.000 13.20195 ? 209 PHE   B CD2 1 
ATOM   4473 C CE1 . PHE   B 1 230 ? 4.69137   1.21979   31.57187  1.000 17.80194 ? 209 PHE   B CE1 1 
ATOM   4474 C CE2 . PHE   B 1 230 ? 5.67920   -0.60077  32.76754  1.000 11.04376 ? 209 PHE   B CE2 1 
ATOM   4475 C CZ  . PHE   B 1 230 ? 5.74746   0.34910   31.76696  1.000 13.93719 ? 209 PHE   B CZ  1 
ATOM   4476 N N   . ALA   B 1 231 ? 0.06076   2.07642   35.58548  1.000 6.06561  ? 210 ALA   B N   1 
ATOM   4477 C CA  . ALA   B 1 231 ? -1.23268  2.36766   36.19188  1.000 8.82848  ? 210 ALA   B CA  1 
ATOM   4478 C C   . ALA   B 1 231 ? -2.28696  2.52220   35.09865  1.000 7.56667  ? 210 ALA   B C   1 
ATOM   4479 O O   . ALA   B 1 231 ? -2.00228  2.38424   33.90431  1.000 7.33290  ? 210 ALA   B O   1 
ATOM   4480 C CB  . ALA   B 1 231 ? -1.16670  3.63001   37.05721  1.000 5.42456  ? 210 ALA   B CB  1 
ATOM   4481 N N   . ASP   B 1 232 ? -3.51431  2.82581   35.52216  1.000 9.58622  ? 211 ASP   B N   1 
ATOM   4482 C CA  . ASP   B 1 232 ? -4.68135  2.90843   34.65358  1.000 5.73406  ? 211 ASP   B CA  1 
ATOM   4483 C C   . ASP   B 1 232 ? -5.12333  4.35941   34.49073  1.000 6.64864  ? 211 ASP   B C   1 
ATOM   4484 O O   . ASP   B 1 232 ? -5.01518  5.16513   35.41892  1.000 9.04368  ? 211 ASP   B O   1 
ATOM   4485 C CB  . ASP   B 1 232 ? -5.85464  2.09803   35.22222  1.000 6.89030  ? 211 ASP   B CB  1 
ATOM   4486 C CG  . ASP   B 1 232 ? -5.52841  0.62798   35.41808  1.000 7.08727  ? 211 ASP   B CG  1 
ATOM   4487 O OD1 . ASP   B 1 232 ? -4.37533  0.21492   35.18122  1.000 8.81694  ? 211 ASP   B OD1 1 
ATOM   4488 O OD2 . ASP   B 1 232 ? -6.44053  -0.12054  35.82303  1.000 10.53462 ? 211 ASP   B OD2 1 
ATOM   4489 N N   . GLY   B 1 233 ? -5.64673  4.68812   33.31365  1.000 6.80248  ? 212 GLY   B N   1 
ATOM   4490 C CA  . GLY   B 1 233 ? -6.14666  6.03293   33.09231  1.000 7.86165  ? 212 GLY   B CA  1 
ATOM   4491 C C   . GLY   B 1 233 ? -6.52824  6.24937   31.64740  1.000 6.76399  ? 212 GLY   B C   1 
ATOM   4492 O O   . GLY   B 1 233 ? -6.22758  5.43959   30.76599  1.000 6.50482  ? 212 GLY   B O   1 
ATOM   4493 N N   . CYS   B 1 234 ? -7.19974  7.37852   31.41654  1.000 6.79733  ? 213 CYS   B N   1 
ATOM   4494 C CA  . CYS   B 1 234 ? -7.66106  7.75287   30.08694  1.000 5.63013  ? 213 CYS   B CA  1 
ATOM   4495 C C   . CYS   B 1 234 ? -7.53669  9.25477   29.88822  1.000 5.60622  ? 213 CYS   B C   1 
ATOM   4496 O O   . CYS   B 1 234 ? -7.87096  10.04069  30.77862  1.000 4.13224  ? 213 CYS   B O   1 
ATOM   4497 C CB  . CYS   B 1 234 ? -9.11667  7.33198   29.84652  1.000 5.48296  ? 213 CYS   B CB  1 
ATOM   4498 S SG  . CYS   B 1 234 ? -9.79461  7.92481   28.26850  1.000 10.18117 ? 213 CYS   B SG  1 
ATOM   4499 N N   . GLY   B 1 235 ? -7.06935  9.64464   28.71112  1.000 5.98465  ? 214 GLY   B N   1 
ATOM   4500 C CA  . GLY   B 1 235 ? -7.07018  11.03816  28.31704  1.000 5.18631  ? 214 GLY   B CA  1 
ATOM   4501 C C   . GLY   B 1 235 ? -7.67719  11.18721  26.94056  1.000 5.32022  ? 214 GLY   B C   1 
ATOM   4502 O O   . GLY   B 1 235 ? -7.68377  10.25542  26.13897  1.000 7.91050  ? 214 GLY   B O   1 
ATOM   4503 N N   . ALA   B 1 236 ? -8.20965  12.37988  26.67878  1.000 6.51529  ? 215 ALA   B N   1 
ATOM   4504 C CA  . ALA   B 1 236 ? -8.80869  12.68104  25.38652  1.000 10.00774 ? 215 ALA   B CA  1 
ATOM   4505 C C   . ALA   B 1 236 ? -8.46940  14.10813  24.99052  1.000 8.37707  ? 215 ALA   B C   1 
ATOM   4506 O O   . ALA   B 1 236 ? -8.24585  14.96986  25.84439  1.000 7.10386  ? 215 ALA   B O   1 
ATOM   4507 C CB  . ALA   B 1 236 ? -10.33327 12.49328  25.39464  1.000 5.84602  ? 215 ALA   B CB  1 
ATOM   4508 N N   . VAL   B 1 237 ? -8.44128  14.35134  23.68411  1.000 8.41227  ? 216 VAL   B N   1 
ATOM   4509 C CA  . VAL   B 1 237 ? -8.07986  15.65460  23.14142  1.000 9.21010  ? 216 VAL   B CA  1 
ATOM   4510 C C   . VAL   B 1 237 ? -8.98160  15.95743  21.95433  1.000 8.55914  ? 216 VAL   B C   1 
ATOM   4511 O O   . VAL   B 1 237 ? -9.28098  15.07460  21.14308  1.000 7.08155  ? 216 VAL   B O   1 
ATOM   4512 C CB  . VAL   B 1 237 ? -6.58916  15.70971  22.74020  1.000 13.72813 ? 216 VAL   B CB  1 
ATOM   4513 C CG1 . VAL   B 1 237 ? -6.22830  14.52695  21.86275  1.000 14.45196 ? 216 VAL   B CG1 1 
ATOM   4514 C CG2 . VAL   B 1 237 ? -6.25838  17.02988  22.04680  1.000 10.93737 ? 216 VAL   B CG2 1 
ATOM   4515 N N   . LEU   B 1 238 ? -9.44272  17.20134  21.87578  1.000 7.58465  ? 217 LEU   B N   1 
ATOM   4516 C CA  . LEU   B 1 238 ? -10.21149 17.68772  20.73949  1.000 9.51884  ? 217 LEU   B CA  1 
ATOM   4517 C C   . LEU   B 1 238 ? -9.28815  18.51459  19.85483  1.000 6.53186  ? 217 LEU   B C   1 
ATOM   4518 O O   . LEU   B 1 238 ? -8.69499  19.49369  20.31912  1.000 9.29150  ? 217 LEU   B O   1 
ATOM   4519 C CB  . LEU   B 1 238 ? -11.40269 18.52503  21.20312  1.000 9.94879  ? 217 LEU   B CB  1 
ATOM   4520 C CG  . LEU   B 1 238 ? -12.22111 19.20128  20.10264  1.000 10.70456 ? 217 LEU   B CG  1 
ATOM   4521 C CD1 . LEU   B 1 238 ? -12.98529 18.16915  19.28065  1.000 14.11377 ? 217 LEU   B CD1 1 
ATOM   4522 C CD2 . LEU   B 1 238 ? -13.16155 20.24166  20.69080  1.000 11.85534 ? 217 LEU   B CD2 1 
ATOM   4523 N N   . MET   B 1 239 ? -9.16637  18.11859  18.58992  1.000 8.25201  ? 218 MET   B N   1 
ATOM   4524 C CA  . MET   B 1 239 ? -8.32180  18.79837  17.61715  1.000 7.20670  ? 218 MET   B CA  1 
ATOM   4525 C C   . MET   B 1 239 ? -9.14941  19.16988  16.39678  1.000 9.29260  ? 218 MET   B C   1 
ATOM   4526 O O   . MET   B 1 239 ? -9.99543  18.39063  15.94844  1.000 12.47039 ? 218 MET   B O   1 
ATOM   4527 C CB  . MET   B 1 239 ? -7.13319  17.92348  17.20366  1.000 7.62149  ? 218 MET   B CB  1 
ATOM   4528 C CG  . MET   B 1 239 ? -6.33150  17.37482  18.37331  1.000 7.60697  ? 218 MET   B CG  1 
ATOM   4529 S SD  . MET   B 1 239 ? -5.15882  16.08829  17.89542  1.000 11.95598 ? 218 MET   B SD  1 
ATOM   4530 C CE  . MET   B 1 239 ? -4.08258  16.96655  16.76645  1.000 9.18922  ? 218 MET   B CE  1 
ATOM   4531 N N   . VAL   B 1 240 ? -8.91468  20.37203  15.87015  1.000 11.57170 ? 219 VAL   B N   1 
ATOM   4532 C CA  . VAL   B 1 240 ? -9.69438  20.89500  14.75732  1.000 10.20778 ? 219 VAL   B CA  1 
ATOM   4533 C C   . VAL   B 1 240 ? -8.75402  21.49465  13.72187  1.000 12.07121 ? 219 VAL   B C   1 
ATOM   4534 O O   . VAL   B 1 240 ? -7.61000  21.85183  14.01321  1.000 16.16168 ? 219 VAL   B O   1 
ATOM   4535 C CB  . VAL   B 1 240 ? -10.73239 21.95002  15.20701  1.000 11.72354 ? 219 VAL   B CB  1 
ATOM   4536 C CG1 . VAL   B 1 240 ? -11.60895 21.41445  16.32602  1.000 14.12896 ? 219 VAL   B CG1 1 
ATOM   4537 C CG2 . VAL   B 1 240 ? -10.03815 23.23462  15.63286  1.000 14.28017 ? 219 VAL   B CG2 1 
ATOM   4538 N N   . GLY   B 1 241 ? -9.25878  21.59844  12.49260  1.000 14.67110 ? 220 GLY   B N   1 
ATOM   4539 C CA  . GLY   B 1 241 ? -8.50091  22.20806  11.42405  1.000 15.82574 ? 220 GLY   B CA  1 
ATOM   4540 C C   . GLY   B 1 241 ? -8.45346  23.72225  11.53111  1.000 20.48466 ? 220 GLY   B C   1 
ATOM   4541 O O   . GLY   B 1 241 ? -9.11678  24.34268  12.36234  1.000 21.25644 ? 220 GLY   B O   1 
ATOM   4542 N N   . LYS   B 1 242 ? -7.65143  24.31727  10.64503  1.000 17.78100 ? 221 LYS   B N   1 
ATOM   4543 C CA  . LYS   B 1 242 ? -7.39425  25.75336  10.70246  1.000 23.71415 ? 221 LYS   B CA  1 
ATOM   4544 C C   . LYS   B 1 242 ? -8.65697  26.57804  10.47695  1.000 19.82261 ? 221 LYS   B C   1 
ATOM   4545 O O   . LYS   B 1 242 ? -8.77460  27.68322  11.01826  1.000 23.22758 ? 221 LYS   B O   1 
ATOM   4546 C CB  . LYS   B 1 242 ? -6.32007  26.12861  9.67694   1.000 27.19192 ? 221 LYS   B CB  1 
ATOM   4547 C CG  . LYS   B 1 242 ? -6.78435  26.05423  8.22567   1.000 36.66925 ? 221 LYS   B CG  1 
ATOM   4548 C CD  . LYS   B 1 242 ? -6.04720  27.04475  7.33400   1.000 45.47659 ? 221 LYS   B CD  1 
ATOM   4549 C CE  . LYS   B 1 242 ? -4.61606  26.59750  7.07635   1.000 46.41136 ? 221 LYS   B CE  1 
ATOM   4550 N NZ  . LYS   B 1 242 ? -3.93613  27.45769  6.06953   1.000 55.47045 ? 221 LYS   B NZ  1 
ATOM   4551 N N   . GLU   B 1 243 ? -9.60623  26.07067  9.68993   1.000 20.45895 ? 222 GLU   B N   1 
ATOM   4552 C CA  . GLU   B 1 243 ? -10.81990 26.80823  9.35918   1.000 26.20791 ? 222 GLU   B CA  1 
ATOM   4553 C C   . GLU   B 1 243 ? -11.99573 26.47911  10.26999  1.000 23.62904 ? 222 GLU   B C   1 
ATOM   4554 O O   . GLU   B 1 243 ? -13.09142 27.00538  10.05556  1.000 18.33077 ? 222 GLU   B O   1 
ATOM   4555 C CB  . GLU   B 1 243 ? -11.21726 26.55078  7.90210   1.000 26.75519 ? 222 GLU   B CB  1 
ATOM   4556 C CG  . GLU   B 1 243 ? -10.22814 27.07378  6.87648   1.000 25.07790 ? 222 GLU   B CG  1 
ATOM   4557 C CD  . GLU   B 1 243 ? -10.54784 26.59668  5.47312   1.000 40.14511 ? 222 GLU   B CD  1 
ATOM   4558 O OE1 . GLU   B 1 243 ? -11.74766 26.52452  5.12902   1.000 36.35420 ? 222 GLU   B OE1 1 
ATOM   4559 O OE2 . GLU   B 1 243 ? -9.60163  26.29571  4.71487   1.000 44.76117 ? 222 GLU   B OE2 1 
ATOM   4560 N N   . HIS   B 1 244 ? -11.80272 25.62641  11.27044  1.000 19.34534 ? 223 HIS   B N   1 
ATOM   4561 C CA  . HIS   B 1 244 ? -12.88950 25.28995  12.17152  1.000 19.60212 ? 223 HIS   B CA  1 
ATOM   4562 C C   . HIS   B 1 244 ? -13.22655 26.48533  13.06271  1.000 17.30705 ? 223 HIS   B C   1 
ATOM   4563 O O   . HIS   B 1 244 ? -12.34746 27.28109  13.40345  1.000 16.43902 ? 223 HIS   B O   1 
ATOM   4564 C CB  . HIS   B 1 244 ? -12.51320 24.08459  13.02793  1.000 16.39467 ? 223 HIS   B CB  1 
ATOM   4565 C CG  . HIS   B 1 244 ? -13.66844 23.47313  13.75802  1.000 17.79341 ? 223 HIS   B CG  1 
ATOM   4566 N ND1 . HIS   B 1 244 ? -14.11446 23.94571  14.97380  1.000 16.01396 ? 223 HIS   B ND1 1 
ATOM   4567 C CD2 . HIS   B 1 244 ? -14.47253 22.43047  13.44216  1.000 14.06636 ? 223 HIS   B CD2 1 
ATOM   4568 C CE1 . HIS   B 1 244 ? -15.14159 23.21910  15.37661  1.000 13.91608 ? 223 HIS   B CE1 1 
ATOM   4569 N NE2 . HIS   B 1 244 ? -15.37870 22.29262  14.46556  1.000 14.65751 ? 223 HIS   B NE2 1 
ATOM   4570 N N   . PRO   B 1 245 ? -14.49798 26.63458  13.44876  1.000 19.81516 ? 224 PRO   B N   1 
ATOM   4571 C CA  . PRO   B 1 245 ? -14.87491 27.76936  14.31077  1.000 21.79658 ? 224 PRO   B CA  1 
ATOM   4572 C C   . PRO   B 1 245 ? -14.10496 27.83911  15.61755  1.000 28.29255 ? 224 PRO   B C   1 
ATOM   4573 O O   . PRO   B 1 245 ? -13.95107 28.93440  16.17002  1.000 28.92927 ? 224 PRO   B O   1 
ATOM   4574 C CB  . PRO   B 1 245 ? -16.37385 27.54424  14.56961  1.000 24.06965 ? 224 PRO   B CB  1 
ATOM   4575 C CG  . PRO   B 1 245 ? -16.78868 26.37126  13.73129  1.000 24.84578 ? 224 PRO   B CG  1 
ATOM   4576 C CD  . PRO   B 1 245 ? -15.66683 25.99483  12.82566  1.000 22.21576 ? 224 PRO   B CD  1 
ATOM   4577 N N   . LEU   B 1 246 ? -13.62046 26.71456  16.13558  1.000 25.01562 ? 225 LEU   B N   1 
ATOM   4578 C CA  . LEU   B 1 246 ? -12.95497 26.69375  17.43109  1.000 16.53843 ? 225 LEU   B CA  1 
ATOM   4579 C C   . LEU   B 1 246 ? -11.45650 26.95602  17.34814  1.000 19.67047 ? 225 LEU   B C   1 
ATOM   4580 O O   . LEU   B 1 246 ? -10.78098 26.90703  18.38000  1.000 22.97574 ? 225 LEU   B O   1 
ATOM   4581 C CB  . LEU   B 1 246 ? -13.20303 25.35265  18.12786  1.000 19.21923 ? 225 LEU   B CB  1 
ATOM   4582 C CG  . LEU   B 1 246 ? -14.66407 25.06039  18.47003  1.000 22.02442 ? 225 LEU   B CG  1 
ATOM   4583 C CD1 . LEU   B 1 246 ? -14.78495 23.73303  19.19951  1.000 16.29190 ? 225 LEU   B CD1 1 
ATOM   4584 C CD2 . LEU   B 1 246 ? -15.25732 26.19223  19.29848  1.000 23.37752 ? 225 LEU   B CD2 1 
ATOM   4585 N N   . ALA   B 1 247 ? -10.92108 27.23664  16.16195  1.000 21.71618 ? 226 ALA   B N   1 
ATOM   4586 C CA  . ALA   B 1 247 ? -9.49030  27.49341  15.99644  1.000 22.55656 ? 226 ALA   B CA  1 
ATOM   4587 C C   . ALA   B 1 247 ? -9.20675  28.95184  16.34095  1.000 27.36705 ? 226 ALA   B C   1 
ATOM   4588 O O   . ALA   B 1 247 ? -9.26345  29.84010  15.48829  1.000 33.54162 ? 226 ALA   B O   1 
ATOM   4589 C CB  . ALA   B 1 247 ? -9.04535  27.15550  14.57896  1.000 21.56079 ? 226 ALA   B CB  1 
ATOM   4590 N N   . LYS   B 1 248 ? -8.88595  29.19728  17.60970  1.000 21.15377 ? 227 LYS   B N   1 
ATOM   4591 C CA  . LYS   B 1 248 ? -8.62195  30.53078  18.13170  1.000 25.77554 ? 227 LYS   B CA  1 
ATOM   4592 C C   . LYS   B 1 248 ? -7.15015  30.69456  18.49269  1.000 24.17565 ? 227 LYS   B C   1 
ATOM   4593 O O   . LYS   B 1 248 ? -6.44737  29.72730  18.79436  1.000 23.23253 ? 227 LYS   B O   1 
ATOM   4594 C CB  . LYS   B 1 248 ? -9.49094  30.82418  19.36133  1.000 21.38918 ? 227 LYS   B CB  1 
ATOM   4595 C CG  . LYS   B 1 248 ? -10.97294 30.56521  19.15743  1.000 30.99582 ? 227 LYS   B CG  1 
ATOM   4596 C CD  . LYS   B 1 248 ? -11.53893 31.52933  18.12903  1.000 36.24969 ? 227 LYS   B CD  1 
ATOM   4597 C CE  . LYS   B 1 248 ? -13.02823 31.31778  17.92629  1.000 40.20843 ? 227 LYS   B CE  1 
ATOM   4598 N NZ  . LYS   B 1 248 ? -13.48192 31.82260  16.59787  1.000 43.51259 ? 227 LYS   B NZ  1 
ATOM   4599 N N   . SER   B 1 249 ? -6.70473  31.95533  18.49378  1.000 21.92841 ? 228 SER   B N   1 
ATOM   4600 C CA  . SER   B 1 249 ? -5.28475  32.27552  18.60839  1.000 26.24247 ? 228 SER   B CA  1 
ATOM   4601 C C   . SER   B 1 249 ? -4.68320  31.91487  19.96311  1.000 27.55386 ? 228 SER   B C   1 
ATOM   4602 O O   . SER   B 1 249 ? -3.45477  31.86778  20.08174  1.000 36.48729 ? 228 SER   B O   1 
ATOM   4603 C CB  . SER   B 1 249 ? -5.06512  33.76373  18.33594  1.000 27.00514 ? 228 SER   B CB  1 
ATOM   4604 O OG  . SER   B 1 249 ? -5.70745  34.55594  19.31931  1.000 29.42516 ? 228 SER   B OG  1 
ATOM   4605 N N   . GLY   B 1 250 ? -5.49753  31.67168  20.98503  1.000 22.46755 ? 229 GLY   B N   1 
ATOM   4606 C CA  . GLY   B 1 250 ? -4.91787  31.30024  22.26317  1.000 30.42887 ? 229 GLY   B CA  1 
ATOM   4607 C C   . GLY   B 1 250 ? -4.49213  29.85113  22.38631  1.000 27.63825 ? 229 GLY   B C   1 
ATOM   4608 O O   . GLY   B 1 250 ? -3.86023  29.48523  23.38314  1.000 21.11892 ? 229 GLY   B O   1 
ATOM   4609 N N   . LEU   B 1 251 ? -4.80061  29.02843  21.39302  1.000 20.03108 ? 230 LEU   B N   1 
ATOM   4610 C CA  . LEU   B 1 251 ? -4.66421  27.58686  21.49399  1.000 20.96386 ? 230 LEU   B CA  1 
ATOM   4611 C C   . LEU   B 1 251 ? -3.32723  27.11484  20.93368  1.000 19.45456 ? 230 LEU   B C   1 
ATOM   4612 O O   . LEU   B 1 251 ? -2.73938  27.77152  20.06847  1.000 19.68714 ? 230 LEU   B O   1 
ATOM   4613 C CB  . LEU   B 1 251 ? -5.80245  26.89688  20.73903  1.000 16.15406 ? 230 LEU   B CB  1 
ATOM   4614 C CG  . LEU   B 1 251 ? -7.20106  27.26747  21.23354  1.000 19.17380 ? 230 LEU   B CG  1 
ATOM   4615 C CD1 . LEU   B 1 251 ? -8.25332  26.70395  20.30142  1.000 17.85760 ? 230 LEU   B CD1 1 
ATOM   4616 C CD2 . LEU   B 1 251 ? -7.41844  26.78825  22.66562  1.000 13.61411 ? 230 LEU   B CD2 1 
ATOM   4617 N N   . PRO   B 1 252 ? -2.81993  25.97794  21.41069  1.000 18.45552 ? 231 PRO   B N   1 
ATOM   4618 C CA  . PRO   B 1 252 ? -1.59540  25.42384  20.82144  1.000 16.74009 ? 231 PRO   B CA  1 
ATOM   4619 C C   . PRO   B 1 252 ? -1.87382  24.84709  19.44264  1.000 15.88332 ? 231 PRO   B C   1 
ATOM   4620 O O   . PRO   B 1 252 ? -2.87134  24.15432  19.22740  1.000 16.29138 ? 231 PRO   B O   1 
ATOM   4621 C CB  . PRO   B 1 252 ? -1.17586  24.32920  21.80929  1.000 19.72357 ? 231 PRO   B CB  1 
ATOM   4622 C CG  . PRO   B 1 252 ? -2.38596  24.01415  22.60830  1.000 16.61617 ? 231 PRO   B CG  1 
ATOM   4623 C CD  . PRO   B 1 252 ? -3.33901  25.16572  22.52684  1.000 14.06346 ? 231 PRO   B CD  1 
ATOM   4624 N N   . GLN   B 1 253 ? -0.97973  25.13816  18.50511  1.000 15.01341 ? 232 GLN   B N   1 
ATOM   4625 C CA  . GLN   B 1 253 ? -1.08180  24.63320  17.14396  1.000 15.63147 ? 232 GLN   B CA  1 
ATOM   4626 C C   . GLN   B 1 253 ? -0.01270  23.57760  16.90972  1.000 17.40237 ? 232 GLN   B C   1 
ATOM   4627 O O   . GLN   B 1 253 ? 1.14602   23.76493  17.29450  1.000 14.28323 ? 232 GLN   B O   1 
ATOM   4628 C CB  . GLN   B 1 253 ? -0.93511  25.75699  16.11524  1.000 18.05413 ? 232 GLN   B CB  1 
ATOM   4629 C CG  . GLN   B 1 253 ? -1.83528  26.95149  16.34857  1.000 20.68310 ? 232 GLN   B CG  1 
ATOM   4630 C CD  . GLN   B 1 253 ? -1.49060  28.11200  15.43659  1.000 34.72419 ? 232 GLN   B CD  1 
ATOM   4631 O OE1 . GLN   B 1 253 ? -0.95868  27.91889  14.34231  1.000 36.55093 ? 232 GLN   B OE1 1 
ATOM   4632 N NE2 . GLN   B 1 253 ? -1.79247  29.32563  15.88208  1.000 39.82505 ? 232 GLN   B NE2 1 
ATOM   4633 N N   . VAL   B 1 254 ? -0.40421  22.46977  16.28777  1.000 14.69241 ? 233 VAL   B N   1 
ATOM   4634 C CA  . VAL   B 1 254 ? 0.55569   21.46201  15.85235  1.000 13.17095 ? 233 VAL   B CA  1 
ATOM   4635 C C   . VAL   B 1 254 ? 1.14011   21.94096  14.52872  1.000 18.51728 ? 233 VAL   B C   1 
ATOM   4636 O O   . VAL   B 1 254 ? 0.45131   21.95696  13.50659  1.000 17.26313 ? 233 VAL   B O   1 
ATOM   4637 C CB  . VAL   B 1 254 ? -0.09461  20.08289  15.70646  1.000 12.28206 ? 233 VAL   B CB  1 
ATOM   4638 C CG1 . VAL   B 1 254 ? 0.95206   19.04407  15.31976  1.000 11.51136 ? 233 VAL   B CG1 1 
ATOM   4639 C CG2 . VAL   B 1 254 ? -0.80692  19.68978  16.99531  1.000 16.86338 ? 233 VAL   B CG2 1 
ATOM   4640 N N   . ILE   B 1 255 ? 2.40778   22.34728  14.54514  1.000 14.11718 ? 234 ILE   B N   1 
ATOM   4641 C CA  . ILE   B 1 255 ? 3.03248   22.87924  13.34128  1.000 18.26848 ? 234 ILE   B CA  1 
ATOM   4642 C C   . ILE   B 1 255 ? 3.92064   21.85760  12.63810  1.000 12.51081 ? 234 ILE   B C   1 
ATOM   4643 O O   . ILE   B 1 255 ? 4.14410   21.98480  11.42460  1.000 12.34657 ? 234 ILE   B O   1 
ATOM   4644 C CB  . ILE   B 1 255 ? 3.82873   24.16311  13.65328  1.000 28.27321 ? 234 ILE   B CB  1 
ATOM   4645 C CG1 . ILE   B 1 255 ? 4.72388   23.96142  14.87154  1.000 17.05971 ? 234 ILE   B CG1 1 
ATOM   4646 C CG2 . ILE   B 1 255 ? 2.87785   25.32605  13.90427  1.000 20.89907 ? 234 ILE   B CG2 1 
ATOM   4647 C CD1 . ILE   B 1 255 ? 5.39637   25.23288  15.33529  1.000 28.63195 ? 234 ILE   B CD1 1 
ATOM   4648 N N   . ASP   B 1 256 ? 4.41421   20.84658  13.34835  1.000 14.55888 ? 235 ASP   B N   1 
ATOM   4649 C CA  . ASP   B 1 256 ? 5.17801   19.77794  12.71911  1.000 14.35587 ? 235 ASP   B CA  1 
ATOM   4650 C C   . ASP   B 1 256 ? 5.22204   18.59524  13.67333  1.000 14.46409 ? 235 ASP   B C   1 
ATOM   4651 O O   . ASP   B 1 256 ? 4.92510   18.72479  14.86362  1.000 13.99465 ? 235 ASP   B O   1 
ATOM   4652 C CB  . ASP   B 1 256 ? 6.59473   20.23681  12.35326  1.000 15.46356 ? 235 ASP   B CB  1 
ATOM   4653 C CG  . ASP   B 1 256 ? 7.20802   19.41736  11.22921  1.000 12.19783 ? 235 ASP   B CG  1 
ATOM   4654 O OD1 . ASP   B 1 256 ? 6.57059   18.44656  10.76476  1.000 16.07067 ? 235 ASP   B OD1 1 
ATOM   4655 O OD2 . ASP   B 1 256 ? 8.33639   19.74663  10.80885  1.000 18.29292 ? 235 ASP   B OD2 1 
ATOM   4656 N N   . ASN   B 1 257 ? 5.58024   17.43378  13.13102  1.000 10.58774 ? 236 ASN   B N   1 
ATOM   4657 C CA  . ASN   B 1 257 ? 5.78823   16.24890  13.95013  1.000 14.85080 ? 236 ASN   B CA  1 
ATOM   4658 C C   . ASN   B 1 257 ? 6.74142   15.31249  13.22556  1.000 15.00173 ? 236 ASN   B C   1 
ATOM   4659 O O   . ASN   B 1 257 ? 6.91368   15.39207  12.00656  1.000 17.46330 ? 236 ASN   B O   1 
ATOM   4660 C CB  . ASN   B 1 257 ? 4.46960   15.53680  14.27399  1.000 10.17760 ? 236 ASN   B CB  1 
ATOM   4661 C CG  . ASN   B 1 257 ? 3.75468   15.03692  13.03409  1.000 18.44799 ? 236 ASN   B CG  1 
ATOM   4662 O OD1 . ASN   B 1 257 ? 4.14862   14.03676  12.43098  1.000 17.48134 ? 236 ASN   B OD1 1 
ATOM   4663 N ND2 . ASN   B 1 257 ? 2.69882   15.73672  12.64410  1.000 13.00119 ? 236 ASN   B ND2 1 
ATOM   4664 N N   . ARG   B 1 258 ? 7.35799   14.41473  13.99076  1.000 14.35901 ? 237 ARG   B N   1 
ATOM   4665 C CA  . ARG   B 1 258 ? 8.32231   13.48987  13.41795  1.000 11.91523 ? 237 ARG   B CA  1 
ATOM   4666 C C   . ARG   B 1 258 ? 8.39454   12.23018  14.26741  1.000 12.23741 ? 237 ARG   B C   1 
ATOM   4667 O O   . ARG   B 1 258 ? 8.26352   12.27872  15.49404  1.000 11.89572 ? 237 ARG   B O   1 
ATOM   4668 C CB  . ARG   B 1 258 ? 9.70687   14.13490  13.30345  1.000 12.84411 ? 237 ARG   B CB  1 
ATOM   4669 C CG  . ARG   B 1 258 ? 10.68790  13.35570  12.44399  1.000 17.23619 ? 237 ARG   B CG  1 
ATOM   4670 C CD  . ARG   B 1 258 ? 11.93038  14.17958  12.17321  1.000 17.26308 ? 237 ARG   B CD  1 
ATOM   4671 N NE  . ARG   B 1 258 ? 11.61982  15.38030  11.40818  1.000 17.96529 ? 237 ARG   B NE  1 
ATOM   4672 C CZ  . ARG   B 1 258 ? 12.52250  16.12953  10.79094  1.000 22.90733 ? 237 ARG   B CZ  1 
ATOM   4673 N NH1 . ARG   B 1 258 ? 13.81072  15.82914  10.82614  1.000 19.74844 ? 237 ARG   B NH1 1 
ATOM   4674 N NH2 . ARG   B 1 258 ? 12.12318  17.21003  10.12560  1.000 22.97880 ? 237 ARG   B NH2 1 
ATOM   4675 N N   . SER   B 1 259 ? 8.60821   11.10315  13.59463  1.000 10.55061 ? 238 SER   B N   1 
ATOM   4676 C CA  . SER   B 1 259 ? 8.80199   9.80615   14.22090  1.000 11.19941 ? 238 SER   B CA  1 
ATOM   4677 C C   . SER   B 1 259 ? 10.24721  9.35631   14.05150  1.000 9.23989  ? 238 SER   B C   1 
ATOM   4678 O O   . SER   B 1 259 ? 10.96431  9.81299   13.15771  1.000 10.78983 ? 238 SER   B O   1 
ATOM   4679 C CB  . SER   B 1 259 ? 7.86359   8.75480   13.61772  1.000 12.79025 ? 238 SER   B CB  1 
ATOM   4680 O OG  . SER   B 1 259 ? 6.52714   9.21814   13.57745  1.000 11.28148 ? 238 SER   B OG  1 
ATOM   4681 N N   . PHE   B 1 260 ? 10.66931  8.45090   14.92961  1.000 8.43533  ? 239 PHE   B N   1 
ATOM   4682 C CA  . PHE   B 1 260 ? 11.99178  7.85303   14.83663  1.000 10.25623 ? 239 PHE   B CA  1 
ATOM   4683 C C   . PHE   B 1 260 ? 11.93671  6.45736   15.43366  1.000 11.85000 ? 239 PHE   B C   1 
ATOM   4684 O O   . PHE   B 1 260 ? 11.33437  6.25349   16.49052  1.000 13.02468 ? 239 PHE   B O   1 
ATOM   4685 C CB  . PHE   B 1 260 ? 13.04758  8.69553   15.56088  1.000 12.57477 ? 239 PHE   B CB  1 
ATOM   4686 C CG  . PHE   B 1 260 ? 14.45488  8.41441   15.11528  1.000 10.19470 ? 239 PHE   B CG  1 
ATOM   4687 C CD1 . PHE   B 1 260 ? 15.16988  7.35633   15.65283  1.000 12.88747 ? 239 PHE   B CD1 1 
ATOM   4688 C CD2 . PHE   B 1 260 ? 15.06054  9.20589   14.15490  1.000 16.40918 ? 239 PHE   B CD2 1 
ATOM   4689 C CE1 . PHE   B 1 260 ? 16.46447  7.09522   15.24356  1.000 12.69256 ? 239 PHE   B CE1 1 
ATOM   4690 C CE2 . PHE   B 1 260 ? 16.35302  8.94883   13.73936  1.000 20.26324 ? 239 PHE   B CE2 1 
ATOM   4691 C CZ  . PHE   B 1 260 ? 17.05536  7.89355   14.28560  1.000 16.36741 ? 239 PHE   B CZ  1 
ATOM   4692 N N   . LEU   B 1 261 ? 12.55913  5.49947   14.75173  1.000 9.84324  ? 240 LEU   B N   1 
ATOM   4693 C CA  . LEU   B 1 261 ? 12.65798  4.13297   15.24701  1.000 10.72113 ? 240 LEU   B CA  1 
ATOM   4694 C C   . LEU   B 1 261 ? 14.12517  3.73339   15.29266  1.000 8.56281  ? 240 LEU   B C   1 
ATOM   4695 O O   . LEU   B 1 261 ? 14.80527  3.74210   14.26093  1.000 12.48022 ? 240 LEU   B O   1 
ATOM   4696 C CB  . LEU   B 1 261 ? 11.86168  3.16965   14.36872  1.000 12.65362 ? 240 LEU   B CB  1 
ATOM   4697 C CG  . LEU   B 1 261 ? 11.74268  1.75901   14.94410  1.000 17.72506 ? 240 LEU   B CG  1 
ATOM   4698 C CD1 . LEU   B 1 261 ? 10.30664  1.26615   14.83054  1.000 14.87665 ? 240 LEU   B CD1 1 
ATOM   4699 C CD2 . LEU   B 1 261 ? 12.71686  0.79983   14.27091  1.000 11.98627 ? 240 LEU   B CD2 1 
ATOM   4700 N N   . VAL   B 1 262 ? 14.60295  3.37484   16.47657  1.000 12.55753 ? 241 VAL   B N   1 
ATOM   4701 C CA  . VAL   B 1 262 ? 16.00415  2.98203   16.64309  1.000 7.61860  ? 241 VAL   B CA  1 
ATOM   4702 C C   . VAL   B 1 262 ? 16.16959  1.54205   16.16368  1.000 12.08226 ? 241 VAL   B C   1 
ATOM   4703 O O   . VAL   B 1 262 ? 15.44848  0.65450   16.64353  1.000 7.51911  ? 241 VAL   B O   1 
ATOM   4704 C CB  . VAL   B 1 262 ? 16.43510  3.12833   18.09924  1.000 9.88079  ? 241 VAL   B CB  1 
ATOM   4705 C CG1 . VAL   B 1 262 ? 17.84130  2.57364   18.29385  1.000 15.55764 ? 241 VAL   B CG1 1 
ATOM   4706 C CG2 . VAL   B 1 262 ? 16.35936  4.58694   18.53535  1.000 14.05615 ? 241 VAL   B CG2 1 
ATOM   4707 N N   . PRO   B 1 263 ? 17.09061  1.27417   15.23733  1.000 8.62489  ? 242 PRO   B N   1 
ATOM   4708 C CA  . PRO   B 1 263 ? 17.22051  -0.08158  14.68972  1.000 8.17351  ? 242 PRO   B CA  1 
ATOM   4709 C C   . PRO   B 1 263 ? 17.56357  -1.11990  15.74964  1.000 9.26804  ? 242 PRO   B C   1 
ATOM   4710 O O   . PRO   B 1 263 ? 18.28154  -0.84645  16.71450  1.000 10.61398 ? 242 PRO   B O   1 
ATOM   4711 C CB  . PRO   B 1 263 ? 18.35919  0.06191   13.67364  1.000 10.56772 ? 242 PRO   B CB  1 
ATOM   4712 C CG  . PRO   B 1 263 ? 18.29373  1.49016   13.25517  1.000 11.32638 ? 242 PRO   B CG  1 
ATOM   4713 C CD  . PRO   B 1 263 ? 17.91781  2.24471   14.50052  1.000 9.87171  ? 242 PRO   B CD  1 
ATOM   4714 N N   . ASN   B 1 264 ? 17.02412  -2.32671  15.55091  1.000 9.31633  ? 243 ASN   B N   1 
ATOM   4715 C CA  . ASN   B 1 264 ? 17.39401  -3.52016  16.31564  1.000 9.49975  ? 243 ASN   B CA  1 
ATOM   4716 C C   . ASN   B 1 264 ? 17.20723  -3.32764  17.81987  1.000 11.06263 ? 243 ASN   B C   1 
ATOM   4717 O O   . ASN   B 1 264 ? 18.07913  -3.65971  18.62415  1.000 6.83228  ? 243 ASN   B O   1 
ATOM   4718 C CB  . ASN   B 1 264 ? 18.82796  -3.94696  15.99512  1.000 11.52966 ? 243 ASN   B CB  1 
ATOM   4719 C CG  . ASN   B 1 264 ? 19.06805  -4.09769  14.50989  1.000 15.49615 ? 243 ASN   B CG  1 
ATOM   4720 O OD1 . ASN   B 1 264 ? 18.40921  -4.89605  13.84514  1.000 14.91953 ? 243 ASN   B OD1 1 
ATOM   4721 N ND2 . ASN   B 1 264 ? 20.02343  -3.34111  13.98109  1.000 14.43458 ? 243 ASN   B ND2 1 
ATOM   4722 N N   . THR   B 1 265 ? 16.04410  -2.79333  18.20052  1.000 7.08387  ? 244 THR   B N   1 
ATOM   4723 C CA  . THR   B 1 265 ? 15.70772  -2.59393  19.60662  1.000 9.97513  ? 244 THR   B CA  1 
ATOM   4724 C C   . THR   B 1 265 ? 14.31429  -3.11897  19.93879  1.000 9.47496  ? 244 THR   B C   1 
ATOM   4725 O O   . THR   B 1 265 ? 13.72580  -2.70328  20.94275  1.000 11.26007 ? 244 THR   B O   1 
ATOM   4726 C CB  . THR   B 1 265 ? 15.81461  -1.11458  19.98625  1.000 9.32314  ? 244 THR   B CB  1 
ATOM   4727 O OG1 . THR   B 1 265 ? 15.03128  -0.33119  19.07961  1.000 13.05685 ? 244 THR   B OG1 1 
ATOM   4728 C CG2 . THR   B 1 265 ? 17.26139  -0.64870  19.94006  1.000 11.76149 ? 244 THR   B CG2 1 
ATOM   4729 N N   . VAL   B 1 266 ? 13.78119  -4.02589  19.11483  1.000 12.81492 ? 245 VAL   B N   1 
ATOM   4730 C CA  . VAL   B 1 266 ? 12.42386  -4.53018  19.31106  1.000 11.40058 ? 245 VAL   B CA  1 
ATOM   4731 C C   . VAL   B 1 266 ? 12.29785  -5.21198  20.66699  1.000 15.45978 ? 245 VAL   B C   1 
ATOM   4732 O O   . VAL   B 1 266 ? 11.30389  -5.03376  21.38083  1.000 12.42761 ? 245 VAL   B O   1 
ATOM   4733 C CB  . VAL   B 1 266 ? 12.04601  -5.48215  18.15987  1.000 9.72023  ? 245 VAL   B CB  1 
ATOM   4734 C CG1 . VAL   B 1 266 ? 10.80047  -6.28587  18.50482  1.000 12.43999 ? 245 VAL   B CG1 1 
ATOM   4735 C CG2 . VAL   B 1 266 ? 11.85528  -4.70452  16.86331  1.000 11.06335 ? 245 VAL   B CG2 1 
ATOM   4736 N N   . GLU   B 1 267 ? 13.31207  -5.98767  21.04990  1.000 13.41082 ? 246 GLU   B N   1 
ATOM   4737 C CA  . GLU   B 1 267 ? 13.28524  -6.76534  22.28326  1.000 19.36540 ? 246 GLU   B CA  1 
ATOM   4738 C C   . GLU   B 1 267 ? 13.45251  -5.91209  23.53500  1.000 17.27659 ? 246 GLU   B C   1 
ATOM   4739 O O   . GLU   B 1 267 ? 13.31025  -6.44106  24.64319  1.000 12.75762 ? 246 GLU   B O   1 
ATOM   4740 C CB  . GLU   B 1 267 ? 14.37411  -7.84906  22.25816  1.000 17.46617 ? 246 GLU   B CB  1 
ATOM   4741 C CG  . GLU   B 1 267 ? 15.80642  -7.37116  21.96513  1.000 27.68538 ? 246 GLU   B CG  1 
ATOM   4742 C CD  . GLU   B 1 267 ? 15.99256  -6.79026  20.57168  1.000 30.61245 ? 246 GLU   B CD  1 
ATOM   4743 O OE1 . GLU   B 1 267 ? 15.77024  -7.52233  19.58171  1.000 26.33126 ? 246 GLU   B OE1 1 
ATOM   4744 O OE2 . GLU   B 1 267 ? 16.35319  -5.59970  20.47012  1.000 26.85207 ? 246 GLU   B OE2 1 
ATOM   4745 N N   . LEU   B 1 268 ? 13.76484  -4.62261  23.39539  1.000 15.32453 ? 247 LEU   B N   1 
ATOM   4746 C CA  . LEU   B 1 268 ? 13.98943  -3.79095  24.57202  1.000 13.27879 ? 247 LEU   B CA  1 
ATOM   4747 C C   . LEU   B 1 268 ? 12.69249  -3.37400  25.25601  1.000 16.17239 ? 247 LEU   B C   1 
ATOM   4748 O O   . LEU   B 1 268 ? 12.68411  -3.18067  26.47658  1.000 14.42802 ? 247 LEU   B O   1 
ATOM   4749 C CB  . LEU   B 1 268 ? 14.80594  -2.55236  24.19972  1.000 11.87681 ? 247 LEU   B CB  1 
ATOM   4750 C CG  . LEU   B 1 268 ? 16.22369  -2.82487  23.69538  1.000 14.38475 ? 247 LEU   B CG  1 
ATOM   4751 C CD1 . LEU   B 1 268 ? 16.99309  -1.52260  23.54617  1.000 15.05026 ? 247 LEU   B CD1 1 
ATOM   4752 C CD2 . LEU   B 1 268 ? 16.95283  -3.77650  24.63149  1.000 20.90591 ? 247 LEU   B CD2 1 
ATOM   4753 N N   . MET   B 1 269 ? 11.59788  -3.21729  24.51249  1.000 13.18405 ? 248 MET   B N   1 
ATOM   4754 C CA  . MET   B 1 269 ? 10.36074  -2.77946  25.14590  1.000 14.39168 ? 248 MET   B CA  1 
ATOM   4755 C C   . MET   B 1 269 ? 9.16649   -3.15731  24.27823  1.000 13.89277 ? 248 MET   B C   1 
ATOM   4756 O O   . MET   B 1 269 ? 9.20369   -3.00986  23.05536  1.000 9.85875  ? 248 MET   B O   1 
ATOM   4757 C CB  . MET   B 1 269 ? 10.39959  -1.26954  25.43304  1.000 13.45605 ? 248 MET   B CB  1 
ATOM   4758 C CG  . MET   B 1 269 ? 9.10081   -0.67608  25.94896  1.000 19.36197 ? 248 MET   B CG  1 
ATOM   4759 S SD  . MET   B 1 269 ? 8.96341   1.10860   25.72191  1.000 25.19437 ? 248 MET   B SD  1 
ATOM   4760 C CE  . MET   B 1 269 ? 10.59923  1.65844   26.17850  1.000 22.31287 ? 248 MET   B CE  1 
ATOM   4761 N N   . GLY   B 1 270 ? 8.12054   -3.65040  24.92972  1.000 11.20829 ? 249 GLY   B N   1 
ATOM   4762 C CA  . GLY   B 1 270 ? 6.92890   -4.10196  24.24204  1.000 10.02014 ? 249 GLY   B CA  1 
ATOM   4763 C C   . GLY   B 1 270 ? 6.05380   -4.88954  25.19302  1.000 16.46647 ? 249 GLY   B C   1 
ATOM   4764 O O   . GLY   B 1 270 ? 6.36721   -5.05300  26.37668  1.000 15.16524 ? 249 GLY   B O   1 
ATOM   4765 N N   . LEU   B 1 271 ? 4.93619   -5.37026  24.65577  1.000 13.18947 ? 250 LEU   B N   1 
ATOM   4766 C CA  . LEU   B 1 271 ? 4.00965   -6.20527  25.40951  1.000 11.77072 ? 250 LEU   B CA  1 
ATOM   4767 C C   . LEU   B 1 271 ? 3.83330   -7.51489  24.65850  1.000 22.72403 ? 250 LEU   B C   1 
ATOM   4768 O O   . LEU   B 1 271 ? 3.33033   -7.52486  23.52855  1.000 17.13318 ? 250 LEU   B O   1 
ATOM   4769 C CB  . LEU   B 1 271 ? 2.66520   -5.50576  25.61630  1.000 13.81902 ? 250 LEU   B CB  1 
ATOM   4770 C CG  . LEU   B 1 271 ? 1.68140   -6.29708  26.48092  1.000 18.46726 ? 250 LEU   B CG  1 
ATOM   4771 C CD1 . LEU   B 1 271 ? 1.98928   -6.07589  27.95613  1.000 19.15727 ? 250 LEU   B CD1 1 
ATOM   4772 C CD2 . LEU   B 1 271 ? 0.23602   -5.92695  26.17299  1.000 17.25223 ? 250 LEU   B CD2 1 
ATOM   4773 N N   . ASP   B 1 272 ? 4.25982   -8.60985  25.27726  1.000 15.97609 ? 251 ASP   B N   1 
ATOM   4774 C CA  . ASP   B 1 272 ? 4.21776   -9.92448  24.65648  1.000 20.24917 ? 251 ASP   B CA  1 
ATOM   4775 C C   . ASP   B 1 272 ? 3.07739   -10.75475 25.22180  1.000 22.99012 ? 251 ASP   B C   1 
ATOM   4776 O O   . ASP   B 1 272 ? 2.77797   -10.69250 26.41706  1.000 20.19656 ? 251 ASP   B O   1 
ATOM   4777 C CB  . ASP   B 1 272 ? 5.53388   -10.67551 24.85662  1.000 20.54286 ? 251 ASP   B CB  1 
ATOM   4778 C CG  . ASP   B 1 272 ? 6.66688   -10.08643 24.05746  1.000 23.31933 ? 251 ASP   B CG  1 
ATOM   4779 O OD1 . ASP   B 1 272 ? 6.39165   -9.40831  23.04530  1.000 27.44933 ? 251 ASP   B OD1 1 
ATOM   4780 O OD2 . ASP   B 1 272 ? 7.83549   -10.32648 24.42913  1.000 25.51403 ? 251 ASP   B OD2 1 
ATOM   4781 N N   . VAL   B 1 273 ? 2.44521   -11.52757 24.34974  1.000 21.17624 ? 252 VAL   B N   1 
ATOM   4782 C CA  . VAL   B 1 273 ? 1.45876   -12.51829 24.75470  1.000 28.52849 ? 252 VAL   B CA  1 
ATOM   4783 C C   . VAL   B 1 273 ? 2.20432   -13.81195 25.05472  1.000 23.44414 ? 252 VAL   B C   1 
ATOM   4784 O O   . VAL   B 1 273 ? 2.93976   -14.32422 24.20405  1.000 27.50142 ? 252 VAL   B O   1 
ATOM   4785 C CB  . VAL   B 1 273 ? 0.39937   -12.72265 23.66298  1.000 27.12518 ? 252 VAL   B CB  1 
ATOM   4786 C CG1 . VAL   B 1 273 ? -0.27354  -14.05413 23.83521  1.000 35.31133 ? 252 VAL   B CG1 1 
ATOM   4787 C CG2 . VAL   B 1 273 ? -0.61788  -11.59775 23.69799  1.000 30.90879 ? 252 VAL   B CG2 1 
ATOM   4788 N N   . VAL   B 1 274 ? 2.03339   -14.33480 26.26756  1.000 25.55419 ? 253 VAL   B N   1 
ATOM   4789 C CA  . VAL   B 1 274 ? 2.78117   -15.49211 26.72877  1.000 28.88623 ? 253 VAL   B CA  1 
ATOM   4790 C C   . VAL   B 1 274 ? 1.82048   -16.48497 27.37431  1.000 27.32840 ? 253 VAL   B C   1 
ATOM   4791 O O   . VAL   B 1 274 ? 0.60900   -16.27394 27.41962  1.000 31.44037 ? 253 VAL   B O   1 
ATOM   4792 C CB  . VAL   B 1 274 ? 3.91335   -15.10707 27.70338  1.000 31.96245 ? 253 VAL   B CB  1 
ATOM   4793 C CG1 . VAL   B 1 274 ? 5.06640   -14.46509 26.94868  1.000 31.27259 ? 253 VAL   B CG1 1 
ATOM   4794 C CG2 . VAL   B 1 274 ? 3.39095   -14.17247 28.78443  1.000 31.40907 ? 253 VAL   B CG2 1 
ATOM   4795 N N   . ASP   B 1 275 ? 2.38700   -17.59061 27.86371  1.000 32.19985 ? 254 ASP   B N   1 
ATOM   4796 C CA  . ASP   B 1 275 ? 1.57680   -18.61939 28.50823  1.000 39.80879 ? 254 ASP   B CA  1 
ATOM   4797 C C   . ASP   B 1 275 ? 0.91462   -18.08930 29.77176  1.000 36.43111 ? 254 ASP   B C   1 
ATOM   4798 O O   . ASP   B 1 275 ? -0.24916  -18.39993 30.04892  1.000 35.91867 ? 254 ASP   B O   1 
ATOM   4799 C CB  . ASP   B 1 275 ? 2.43704   -19.84119 28.82610  1.000 39.92214 ? 254 ASP   B CB  1 
ATOM   4800 C CG  . ASP   B 1 275 ? 2.73259   -20.67487 27.60033  1.000 38.04748 ? 254 ASP   B CG  1 
ATOM   4801 O OD1 . ASP   B 1 275 ? 1.77921   -21.21734 27.00122  1.000 44.72383 ? 254 ASP   B OD1 1 
ATOM   4802 O OD2 . ASP   B 1 275 ? 3.92002   -20.77932 27.23156  1.000 36.85223 ? 254 ASP   B OD2 1 
ATOM   4803 N N   . ASN   B 1 276 ? 1.63958   -17.28868 30.55043  1.000 40.64393 ? 255 ASN   B N   1 
ATOM   4804 C CA  . ASN   B 1 276 ? 1.10911   -16.72326 31.78380  1.000 39.57994 ? 255 ASN   B CA  1 
ATOM   4805 C C   . ASN   B 1 276 ? 0.16362   -15.55117 31.54572  1.000 37.92557 ? 255 ASN   B C   1 
ATOM   4806 O O   . ASN   B 1 276 ? -0.29320  -14.94223 32.51812  1.000 34.29920 ? 255 ASN   B O   1 
ATOM   4807 C CB  . ASN   B 1 276 ? 2.26075   -16.28336 32.69538  1.000 36.87513 ? 255 ASN   B CB  1 
ATOM   4808 C CG  . ASN   B 1 276 ? 3.19210   -17.42898 33.05501  1.000 36.83436 ? 255 ASN   B CG  1 
ATOM   4809 O OD1 . ASN   B 1 276 ? 2.78010   -18.58894 33.09235  1.000 36.68954 ? 255 ASN   B OD1 1 
ATOM   4810 N ND2 . ASN   B 1 276 ? 4.45154   -17.10630 33.33407  1.000 34.22252 ? 255 ASN   B ND2 1 
ATOM   4811 N N   . GLY   B 1 277 ? -0.14700  -15.22868 30.29131  1.000 35.41183 ? 256 GLY   B N   1 
ATOM   4812 C CA  . GLY   B 1 277 ? -1.00586  -14.10309 29.97603  1.000 30.04467 ? 256 GLY   B CA  1 
ATOM   4813 C C   . GLY   B 1 277 ? -0.28469  -13.06584 29.14436  1.000 30.91379 ? 256 GLY   B C   1 
ATOM   4814 O O   . GLY   B 1 277 ? 0.15997   -13.35171 28.02883  1.000 31.37539 ? 256 GLY   B O   1 
ATOM   4815 N N   . PHE   B 1 278 ? -0.17247  -11.85468 29.67413  1.000 26.06084 ? 257 PHE   B N   1 
ATOM   4816 C CA  . PHE   B 1 278 ? 0.69846   -10.83360 29.11739  1.000 24.05608 ? 257 PHE   B CA  1 
ATOM   4817 C C   . PHE   B 1 278 ? 2.01433   -10.82920 29.88115  1.000 29.25242 ? 257 PHE   B C   1 
ATOM   4818 O O   . PHE   B 1 278 ? 2.07021   -11.20108 31.05594  1.000 22.03744 ? 257 PHE   B O   1 
ATOM   4819 C CB  . PHE   B 1 278 ? 0.06688   -9.44153  29.21022  1.000 25.79871 ? 257 PHE   B CB  1 
ATOM   4820 C CG  . PHE   B 1 278 ? -1.26820  -9.31955  28.53454  1.000 36.33996 ? 257 PHE   B CG  1 
ATOM   4821 C CD1 . PHE   B 1 278 ? -1.37086  -9.36367  27.15424  1.000 28.41775 ? 257 PHE   B CD1 1 
ATOM   4822 C CD2 . PHE   B 1 278 ? -2.42120  -9.13516  29.28244  1.000 36.32060 ? 257 PHE   B CD2 1 
ATOM   4823 C CE1 . PHE   B 1 278 ? -2.59926  -9.23788  26.53220  1.000 31.82247 ? 257 PHE   B CE1 1 
ATOM   4824 C CE2 . PHE   B 1 278 ? -3.65213  -9.00991  28.66669  1.000 28.82588 ? 257 PHE   B CE2 1 
ATOM   4825 C CZ  . PHE   B 1 278 ? -3.74048  -9.06146  27.29010  1.000 33.11414 ? 257 PHE   B CZ  1 
ATOM   4826 N N   . ARG   B 1 279 ? 3.07923   -10.39968 29.21235  1.000 15.54413 ? 258 ARG   B N   1 
ATOM   4827 C CA  . ARG   B 1 279 ? 4.29359   -10.01617 29.91859  1.000 19.96668 ? 258 ARG   B CA  1 
ATOM   4828 C C   . ARG   B 1 279 ? 4.77154   -8.68035  29.38059  1.000 18.17997 ? 258 ARG   B C   1 
ATOM   4829 O O   . ARG   B 1 279 ? 5.05818   -8.55266  28.18644  1.000 19.75364 ? 258 ARG   B O   1 
ATOM   4830 C CB  . ARG   B 1 279 ? 5.40267   -11.06392 29.80543  1.000 21.17854 ? 258 ARG   B CB  1 
ATOM   4831 C CG  . ARG   B 1 279 ? 6.41178   -10.89392 30.93688  1.000 18.41335 ? 258 ARG   B CG  1 
ATOM   4832 C CD  . ARG   B 1 279 ? 7.74250   -11.56511 30.68854  1.000 24.73140 ? 258 ARG   B CD  1 
ATOM   4833 N NE  . ARG   B 1 279 ? 8.64206   -11.33145 31.81256  1.000 18.35650 ? 258 ARG   B NE  1 
ATOM   4834 C CZ  . ARG   B 1 279 ? 9.94847   -11.55244 31.79011  1.000 22.16546 ? 258 ARG   B CZ  1 
ATOM   4835 N NH1 . ARG   B 1 279 ? 10.55203  -12.01866 30.70913  1.000 25.48968 ? 258 ARG   B NH1 1 
ATOM   4836 N NH2 . ARG   B 1 279 ? 10.66880  -11.29258 32.87808  1.000 24.03774 ? 258 ARG   B NH2 1 
ATOM   4837 N N   . ASN   B 1 280 ? 4.83937   -7.68956  30.25942  1.000 16.32689 ? 259 ASN   B N   1 
ATOM   4838 C CA  . ASN   B 1 280 ? 5.45261   -6.41878  29.91394  1.000 17.40422 ? 259 ASN   B CA  1 
ATOM   4839 C C   . ASN   B 1 280 ? 6.96006   -6.56744  29.76580  1.000 15.56384 ? 259 ASN   B C   1 
ATOM   4840 O O   . ASN   B 1 280 ? 7.62352   -7.17033  30.61472  1.000 14.84052 ? 259 ASN   B O   1 
ATOM   4841 C CB  . ASN   B 1 280 ? 5.12382   -5.37894  30.97827  1.000 14.00850 ? 259 ASN   B CB  1 
ATOM   4842 C CG  . ASN   B 1 280 ? 5.73559   -4.03755  30.67679  1.000 15.83403 ? 259 ASN   B CG  1 
ATOM   4843 O OD1 . ASN   B 1 280 ? 6.49012   -3.49863  31.48188  1.000 19.15311 ? 259 ASN   B OD1 1 
ATOM   4844 N ND2 . ASN   B 1 280 ? 5.48072   -3.52661  29.48694  1.000 17.80544 ? 259 ASN   B ND2 1 
ATOM   4845 N N   . ILE   B 1 281 ? 7.50001   -6.00618  28.68869  1.000 9.13551  ? 260 ILE   B N   1 
ATOM   4846 C CA  . ILE   B 1 281 ? 8.93392   -6.00996  28.42764  1.000 12.88040 ? 260 ILE   B CA  1 
ATOM   4847 C C   . ILE   B 1 281 ? 9.44551   -4.59053  28.61814  1.000 16.23770 ? 260 ILE   B C   1 
ATOM   4848 O O   . ILE   B 1 281 ? 8.97434   -3.65729  27.95503  1.000 12.29106 ? 260 ILE   B O   1 
ATOM   4849 C CB  . ILE   B 1 281 ? 9.26041   -6.52551  27.01789  1.000 16.01394 ? 260 ILE   B CB  1 
ATOM   4850 C CG1 . ILE   B 1 281 ? 8.63306   -7.90385  26.78398  1.000 13.84926 ? 260 ILE   B CG1 1 
ATOM   4851 C CG2 . ILE   B 1 281 ? 10.76590  -6.57041  26.81232  1.000 12.49347 ? 260 ILE   B CG2 1 
ATOM   4852 C CD1 . ILE   B 1 281 ? 9.20723   -9.00532  27.65684  1.000 16.99103 ? 260 ILE   B CD1 1 
ATOM   4853 N N   . LEU   B 1 282 ? 10.40326  -4.42610  29.53241  1.000 11.06497 ? 261 LEU   B N   1 
ATOM   4854 C CA  . LEU   B 1 282 ? 11.04673  -3.13223  29.74824  1.000 7.36377  ? 261 LEU   B CA  1 
ATOM   4855 C C   . LEU   B 1 282 ? 12.46675  -3.41151  30.23545  1.000 13.63905 ? 261 LEU   B C   1 
ATOM   4856 O O   . LEU   B 1 282 ? 12.68443  -3.62664  31.43034  1.000 14.19634 ? 261 LEU   B O   1 
ATOM   4857 C CB  . LEU   B 1 282 ? 10.25979  -2.28869  30.74141  1.000 12.92044 ? 261 LEU   B CB  1 
ATOM   4858 C CG  . LEU   B 1 282 ? 10.77841  -0.87753  31.00824  1.000 20.71449 ? 261 LEU   B CG  1 
ATOM   4859 C CD1 . LEU   B 1 282 ? 10.48448  0.01843   29.81633  1.000 21.11532 ? 261 LEU   B CD1 1 
ATOM   4860 C CD2 . LEU   B 1 282 ? 10.14008  -0.31201  32.26588  1.000 15.94826 ? 261 LEU   B CD2 1 
ATOM   4861 N N   . ARG   B 1 283 ? 13.42015  -3.40543  29.30894  1.000 13.81915 ? 262 ARG   B N   1 
ATOM   4862 C CA  . ARG   B 1 283 ? 14.79357  -3.74006  29.65052  1.000 18.92710 ? 262 ARG   B CA  1 
ATOM   4863 C C   . ARG   B 1 283 ? 15.55554  -2.50219  30.11443  1.000 21.01394 ? 262 ARG   B C   1 
ATOM   4864 O O   . ARG   B 1 283 ? 15.26351  -1.38448  29.67750  1.000 16.75306 ? 262 ARG   B O   1 
ATOM   4865 C CB  . ARG   B 1 283 ? 15.50414  -4.35576  28.44955  1.000 18.73248 ? 262 ARG   B CB  1 
ATOM   4866 C CG  . ARG   B 1 283 ? 14.77470  -5.53381  27.83013  1.000 20.62479 ? 262 ARG   B CG  1 
ATOM   4867 C CD  . ARG   B 1 283 ? 15.12595  -6.84162  28.52495  1.000 17.62633 ? 262 ARG   B CD  1 
ATOM   4868 N NE  . ARG   B 1 283 ? 14.21702  -7.91576  28.14220  1.000 23.30783 ? 262 ARG   B NE  1 
ATOM   4869 C CZ  . ARG   B 1 283 ? 13.96567  -8.98789  28.88151  1.000 28.59250 ? 262 ARG   B CZ  1 
ATOM   4870 N NH1 . ARG   B 1 283 ? 14.53245  -9.16115  30.06451  1.000 24.22439 ? 262 ARG   B NH1 1 
ATOM   4871 N NH2 . ARG   B 1 283 ? 13.12218  -9.90883  28.42304  1.000 26.89734 ? 262 ARG   B NH2 1 
ATOM   4872 N N   . PRO   B 1 284 ? 16.54081  -2.67744  31.00004  1.000 29.64824 ? 263 PRO   B N   1 
ATOM   4873 C CA  . PRO   B 1 284 ? 17.31245  -1.51602  31.47873  1.000 24.70455 ? 263 PRO   B CA  1 
ATOM   4874 C C   . PRO   B 1 284 ? 18.09877  -0.80419  30.38997  1.000 25.99790 ? 263 PRO   B C   1 
ATOM   4875 O O   . PRO   B 1 284 ? 18.46687  0.36041   30.58004  1.000 29.68598 ? 263 PRO   B O   1 
ATOM   4876 C CB  . PRO   B 1 284 ? 18.24534  -2.11808  32.54173  1.000 28.15813 ? 263 PRO   B CB  1 
ATOM   4877 C CG  . PRO   B 1 284 ? 18.22326  -3.59266  32.31408  1.000 24.48971 ? 263 PRO   B CG  1 
ATOM   4878 C CD  . PRO   B 1 284 ? 16.89710  -3.91870  31.70690  1.000 20.15194 ? 263 PRO   B CD  1 
ATOM   4879 N N   . GLU   B 1 285 ? 18.36750  -1.45352  29.25911  1.000 22.23940 ? 264 GLU   B N   1 
ATOM   4880 C CA  . GLU   B 1 285 ? 19.08716  -0.81748  28.16205  1.000 21.84182 ? 264 GLU   B CA  1 
ATOM   4881 C C   . GLU   B 1 285 ? 18.21733  0.12698   27.34219  1.000 26.07148 ? 264 GLU   B C   1 
ATOM   4882 O O   . GLU   B 1 285 ? 18.69369  0.66689   26.33723  1.000 28.43812 ? 264 GLU   B O   1 
ATOM   4883 C CB  . GLU   B 1 285 ? 19.70556  -1.88700  27.25862  1.000 27.22395 ? 264 GLU   B CB  1 
ATOM   4884 C CG  . GLU   B 1 285 ? 20.50133  -2.93751  28.02727  1.000 27.35293 ? 264 GLU   B CG  1 
ATOM   4885 C CD  . GLU   B 1 285 ? 19.68988  -4.17052  28.36452  1.000 31.77737 ? 264 GLU   B CD  1 
ATOM   4886 O OE1 . GLU   B 1 285 ? 20.14223  -5.28906  28.05526  1.000 44.12716 ? 264 GLU   B OE1 1 
ATOM   4887 O OE2 . GLU   B 1 285 ? 18.60080  -4.02459  28.95497  1.000 34.42961 ? 264 GLU   B OE2 1 
ATOM   4888 N N   . VAL   B 1 286 ? 16.95988  0.32935   27.73852  1.000 23.41744 ? 265 VAL   B N   1 
ATOM   4889 C CA  . VAL   B 1 286 ? 16.10281  1.29405   27.05608  1.000 21.78280 ? 265 VAL   B CA  1 
ATOM   4890 C C   . VAL   B 1 286 ? 16.67001  2.70226   27.19320  1.000 27.39647 ? 265 VAL   B C   1 
ATOM   4891 O O   . VAL   B 1 286 ? 16.68559  3.47889   26.22962  1.000 19.33581 ? 265 VAL   B O   1 
ATOM   4892 C CB  . VAL   B 1 286 ? 14.66601  1.20235   27.60437  1.000 19.81674 ? 265 VAL   B CB  1 
ATOM   4893 C CG1 . VAL   B 1 286 ? 13.90124  2.49060   27.33793  1.000 22.25929 ? 265 VAL   B CG1 1 
ATOM   4894 C CG2 . VAL   B 1 286 ? 13.94591  0.00444   27.00515  1.000 18.98572 ? 265 VAL   B CG2 1 
ATOM   4895 N N   . SER   B 1 287 ? 17.14879  3.05131   28.39144  1.000 29.97052 ? 266 SER   B N   1 
ATOM   4896 C CA  . SER   B 1 287 ? 17.65396  4.40057   28.63127  1.000 30.34183 ? 266 SER   B CA  1 
ATOM   4897 C C   . SER   B 1 287 ? 18.81096  4.73840   27.69935  1.000 28.66794 ? 266 SER   B C   1 
ATOM   4898 O O   . SER   B 1 287 ? 18.94074  5.88200   27.24725  1.000 33.82802 ? 266 SER   B O   1 
ATOM   4899 C CB  . SER   B 1 287 ? 18.08409  4.54659   30.09069  1.000 31.54862 ? 266 SER   B CB  1 
ATOM   4900 O OG  . SER   B 1 287 ? 16.98815  4.34496   30.96544  1.000 46.63353 ? 266 SER   B OG  1 
ATOM   4901 N N   . ASP   B 1 288 ? 19.66196  3.75806   27.39961  1.000 34.18515 ? 267 ASP   B N   1 
ATOM   4902 C CA  . ASP   B 1 288 ? 20.79822  4.00799   26.52312  1.000 32.79265 ? 267 ASP   B CA  1 
ATOM   4903 C C   . ASP   B 1 288 ? 20.41846  3.93000   25.04881  1.000 28.01106 ? 267 ASP   B C   1 
ATOM   4904 O O   . ASP   B 1 288 ? 21.05361  4.58727   24.21758  1.000 35.63832 ? 267 ASP   B O   1 
ATOM   4905 C CB  . ASP   B 1 288 ? 21.92556  3.02416   26.84725  1.000 47.70726 ? 267 ASP   B CB  1 
ATOM   4906 C CG  . ASP   B 1 288 ? 22.10947  2.82447   28.34378  1.000 48.23102 ? 267 ASP   B CG  1 
ATOM   4907 O OD1 . ASP   B 1 288 ? 22.32545  3.82919   29.05778  1.000 45.19147 ? 267 ASP   B OD1 1 
ATOM   4908 O OD2 . ASP   B 1 288 ? 22.03423  1.66722   28.80865  1.000 47.15949 ? 267 ASP   B OD2 1 
ATOM   4909 N N   . ALA   B 1 289 ? 19.39483  3.14546   24.70365  1.000 31.18240 ? 268 ALA   B N   1 
ATOM   4910 C CA  . ALA   B 1 289 ? 18.88549  3.16707   23.33682  1.000 23.65927 ? 268 ALA   B CA  1 
ATOM   4911 C C   . ALA   B 1 289 ? 18.09917  4.44047   23.05938  1.000 18.80465 ? 268 ALA   B C   1 
ATOM   4912 O O   . ALA   B 1 289 ? 18.06711  4.91325   21.91697  1.000 18.67896 ? 268 ALA   B O   1 
ATOM   4913 C CB  . ALA   B 1 289 ? 18.01575  1.93824   23.07465  1.000 29.12238 ? 268 ALA   B CB  1 
ATOM   4914 N N   . LEU   B 1 290 ? 17.46252  5.00150   24.09043  1.000 20.81762 ? 269 LEU   B N   1 
ATOM   4915 C CA  . LEU   B 1 290 ? 16.76015  6.27187   23.94910  1.000 23.28593 ? 269 LEU   B CA  1 
ATOM   4916 C C   . LEU   B 1 290 ? 17.68586  7.35490   23.41330  1.000 18.07949 ? 269 LEU   B C   1 
ATOM   4917 O O   . LEU   B 1 290 ? 17.29325  8.15246   22.55299  1.000 16.99944 ? 269 LEU   B O   1 
ATOM   4918 C CB  . LEU   B 1 290 ? 16.18269  6.69242   25.30162  1.000 25.75583 ? 269 LEU   B CB  1 
ATOM   4919 C CG  . LEU   B 1 290 ? 14.72266  7.13753   25.37904  1.000 32.16837 ? 269 LEU   B CG  1 
ATOM   4920 C CD1 . LEU   B 1 290 ? 13.78551  6.03096   24.91028  1.000 33.02353 ? 269 LEU   B CD1 1 
ATOM   4921 C CD2 . LEU   B 1 290 ? 14.38967  7.56903   26.79713  1.000 25.74380 ? 269 LEU   B CD2 1 
ATOM   4922 N N   . LYS   B 1 291 ? 18.92592  7.38966   23.90962  1.000 14.63807 ? 270 LYS   B N   1 
ATOM   4923 C CA  . LYS   B 1 291 ? 19.88908  8.39273   23.46835  1.000 19.61534 ? 270 LYS   B CA  1 
ATOM   4924 C C   . LYS   B 1 291 ? 20.18241  8.27850   21.97856  1.000 16.35241 ? 270 LYS   B C   1 
ATOM   4925 O O   . LYS   B 1 291 ? 20.45713  9.28926   21.32283  1.000 19.78708 ? 270 LYS   B O   1 
ATOM   4926 C CB  . LYS   B 1 291 ? 21.18653  8.25955   24.26891  1.000 13.94691 ? 270 LYS   B CB  1 
ATOM   4927 C CG  . LYS   B 1 291 ? 21.02989  8.48049   25.76682  1.000 21.63210 ? 270 LYS   B CG  1 
ATOM   4928 C CD  . LYS   B 1 291 ? 22.34822  8.24798   26.49542  1.000 15.71633 ? 270 LYS   B CD  1 
ATOM   4929 C CE  . LYS   B 1 291 ? 22.13784  8.08513   27.99038  1.000 25.28396 ? 270 LYS   B CE  1 
ATOM   4930 N NZ  . LYS   B 1 291 ? 23.39375  7.69488   28.68764  1.000 34.46915 ? 270 LYS   B NZ  1 
ATOM   4931 N N   . GLN   B 1 292 ? 20.13280  7.06464   21.42460  1.000 15.13099 ? 271 GLN   B N   1 
ATOM   4932 C CA  . GLN   B 1 292 ? 20.41945  6.89222   20.00506  1.000 14.77081 ? 271 GLN   B CA  1 
ATOM   4933 C C   . GLN   B 1 292 ? 19.37027  7.53334   19.10873  1.000 15.91913 ? 271 GLN   B C   1 
ATOM   4934 O O   . GLN   B 1 292 ? 19.65924  7.80092   17.93897  1.000 20.48259 ? 271 GLN   B O   1 
ATOM   4935 C CB  . GLN   B 1 292 ? 20.53595  5.41016   19.65410  1.000 16.65081 ? 271 GLN   B CB  1 
ATOM   4936 C CG  . GLN   B 1 292 ? 21.47237  4.61787   20.53588  1.000 15.48452 ? 271 GLN   B CG  1 
ATOM   4937 C CD  . GLN   B 1 292 ? 21.44861  3.14247   20.19957  1.000 18.59952 ? 271 GLN   B CD  1 
ATOM   4938 O OE1 . GLN   B 1 292 ? 21.18392  2.76243   19.05941  1.000 23.95311 ? 271 GLN   B OE1 1 
ATOM   4939 N NE2 . GLN   B 1 292 ? 21.73601  2.30225   21.18652  1.000 22.50863 ? 271 GLN   B NE2 1 
ATOM   4940 N N   . GLY   B 1 293 ? 18.16657  7.77544   19.61701  1.000 14.27273 ? 272 GLY   B N   1 
ATOM   4941 C CA  . GLY   B 1 293 ? 17.10789  8.30291   18.77991  1.000 17.36592 ? 272 GLY   B CA  1 
ATOM   4942 C C   . GLY   B 1 293 ? 16.62727  9.68672   19.16099  1.000 16.84759 ? 272 GLY   B C   1 
ATOM   4943 O O   . GLY   B 1 293 ? 16.14363  10.43378  18.30511  1.000 10.19152 ? 272 GLY   B O   1 
ATOM   4944 N N   . LEU   B 1 294 ? 16.76673  10.04108  20.44094  1.000 15.97463 ? 273 LEU   B N   1 
ATOM   4945 C CA  . LEU   B 1 294 ? 16.16095  11.26882  20.95172  1.000 19.47195 ? 273 LEU   B CA  1 
ATOM   4946 C C   . LEU   B 1 294 ? 16.72007  12.50459  20.25764  1.000 14.90146 ? 273 LEU   B C   1 
ATOM   4947 O O   . LEU   B 1 294 ? 15.96677  13.33096  19.72868  1.000 12.39207 ? 273 LEU   B O   1 
ATOM   4948 C CB  . LEU   B 1 294 ? 16.38170  11.36279  22.46158  1.000 15.57411 ? 273 LEU   B CB  1 
ATOM   4949 C CG  . LEU   B 1 294 ? 15.17381  11.08391  23.35485  1.000 31.48006 ? 273 LEU   B CG  1 
ATOM   4950 C CD1 . LEU   B 1 294 ? 15.62074  10.82847  24.78370  1.000 27.45598 ? 273 LEU   B CD1 1 
ATOM   4951 C CD2 . LEU   B 1 294 ? 14.19441  12.24359  23.29923  1.000 24.93110 ? 273 LEU   B CD2 1 
ATOM   4952 N N   . ARG   B 1 295 ? 18.03648  12.64377  20.23963  1.000 14.71256 ? 274 ARG   B N   1 
ATOM   4953 C CA  . ARG   B 1 295 ? 18.62508  13.86483  19.70776  1.000 19.07805 ? 274 ARG   B CA  1 
ATOM   4954 C C   . ARG   B 1 295 ? 18.54869  13.92534  18.18384  1.000 13.65506 ? 274 ARG   B C   1 
ATOM   4955 O O   . ARG   B 1 295 ? 18.23420  14.99111  17.64573  1.000 14.82720 ? 274 ARG   B O   1 
ATOM   4956 C CB  . ARG   B 1 295 ? 20.06341  14.02439  20.20179  1.000 21.92427 ? 274 ARG   B CB  1 
ATOM   4957 C CG  . ARG   B 1 295 ? 20.12996  14.87916  21.45481  1.000 22.06225 ? 274 ARG   B CG  1 
ATOM   4958 C CD  . ARG   B 1 295 ? 21.49126  15.48754  21.67406  1.000 23.11253 ? 274 ARG   B CD  1 
ATOM   4959 N NE  . ARG   B 1 295 ? 22.33436  14.62369  22.48991  1.000 19.03665 ? 274 ARG   B NE  1 
ATOM   4960 C CZ  . ARG   B 1 295 ? 23.55406  14.94133  22.90031  1.000 13.23159 ? 274 ARG   B CZ  1 
ATOM   4961 N NH1 . ARG   B 1 295 ? 24.10124  16.10860  22.60226  1.000 15.57151 ? 274 ARG   B NH1 1 
ATOM   4962 N NH2 . ARG   B 1 295 ? 24.23847  14.06897  23.63369  1.000 17.47272 ? 274 ARG   B NH2 1 
ATOM   4963 N N   . PRO   B 1 296 ? 18.81936  12.84297  17.44253  1.000 12.80410 ? 275 PRO   B N   1 
ATOM   4964 C CA  . PRO   B 1 296 ? 18.56371  12.91171  15.99102  1.000 19.57380 ? 275 PRO   B CA  1 
ATOM   4965 C C   . PRO   B 1 296 ? 17.12201  13.26242  15.65737  1.000 12.13715 ? 275 PRO   B C   1 
ATOM   4966 O O   . PRO   B 1 296 ? 16.87631  14.03444  14.72242  1.000 15.77270 ? 275 PRO   B O   1 
ATOM   4967 C CB  . PRO   B 1 296 ? 18.94166  11.50739  15.48986  1.000 15.40450 ? 275 PRO   B CB  1 
ATOM   4968 C CG  . PRO   B 1 296 ? 19.17494  10.68064  16.70777  1.000 19.74007 ? 275 PRO   B CG  1 
ATOM   4969 C CD  . PRO   B 1 296 ? 19.53318  11.60832  17.80829  1.000 14.04949 ? 275 PRO   B CD  1 
ATOM   4970 N N   . LEU   B 1 297 ? 16.15999  12.72873  16.41433  1.000 11.44990 ? 276 LEU   B N   1 
ATOM   4971 C CA  . LEU   B 1 297 ? 14.75439  13.05586  16.18584  1.000 12.42712 ? 276 LEU   B CA  1 
ATOM   4972 C C   . LEU   B 1 297 ? 14.46873  14.52676  16.46978  1.000 16.73828 ? 276 LEU   B C   1 
ATOM   4973 O O   . LEU   B 1 297 ? 13.90719  15.23666  15.62646  1.000 13.03472 ? 276 LEU   B O   1 
ATOM   4974 C CB  . LEU   B 1 297 ? 13.86743  12.17036  17.06232  1.000 7.61570  ? 276 LEU   B CB  1 
ATOM   4975 C CG  . LEU   B 1 297 ? 12.38560  12.54150  17.13240  1.000 10.12313 ? 276 LEU   B CG  1 
ATOM   4976 C CD1 . LEU   B 1 297 ? 11.77808  12.53666  15.74054  1.000 11.30126 ? 276 LEU   B CD1 1 
ATOM   4977 C CD2 . LEU   B 1 297 ? 11.63288  11.60906  18.06194  1.000 7.06524  ? 276 LEU   B CD2 1 
ATOM   4978 N N   . ILE   B 1 298 ? 14.85123  15.00132  17.65532  1.000 10.11653 ? 277 ILE   B N   1 
ATOM   4979 C CA  . ILE   B 1 298 ? 14.44999  16.33471  18.09077  1.000 9.41744  ? 277 ILE   B CA  1 
ATOM   4980 C C   . ILE   B 1 298 ? 15.30387  17.41068  17.43254  1.000 13.34140 ? 277 ILE   B C   1 
ATOM   4981 O O   . ILE   B 1 298 ? 14.78994  18.46149  17.03310  1.000 13.20484 ? 277 ILE   B O   1 
ATOM   4982 C CB  . ILE   B 1 298 ? 14.49494  16.41829  19.62622  1.000 16.10991 ? 277 ILE   B CB  1 
ATOM   4983 C CG1 . ILE   B 1 298 ? 13.36778  15.57106  20.22135  1.000 9.98399  ? 277 ILE   B CG1 1 
ATOM   4984 C CG2 . ILE   B 1 298 ? 14.39228  17.86107  20.09602  1.000 15.75494 ? 277 ILE   B CG2 1 
ATOM   4985 C CD1 . ILE   B 1 298 ? 13.42452  15.43418  21.72474  1.000 9.68726  ? 277 ILE   B CD1 1 
ATOM   4986 N N   . ASN   B 1 299 ? 16.61313  17.17683  17.30436  1.000 17.79617 ? 278 ASN   B N   1 
ATOM   4987 C CA  . ASN   B 1 299 ? 17.46455  18.16372  16.64469  1.000 16.84630 ? 278 ASN   B CA  1 
ATOM   4988 C C   . ASN   B 1 299 ? 17.02897  18.37596  15.20082  1.000 15.32608 ? 278 ASN   B C   1 
ATOM   4989 O O   . ASN   B 1 299 ? 16.96119  19.51462  14.72408  1.000 17.44700 ? 278 ASN   B O   1 
ATOM   4990 C CB  . ASN   B 1 299 ? 18.93001  17.72857  16.69160  1.000 13.55199 ? 278 ASN   B CB  1 
ATOM   4991 C CG  . ASN   B 1 299 ? 19.56530  17.93461  18.05523  1.000 21.93485 ? 278 ASN   B CG  1 
ATOM   4992 O OD1 . ASN   B 1 299 ? 18.95542  18.50121  18.96351  1.000 25.86092 ? 278 ASN   B OD1 1 
ATOM   4993 N ND2 . ASN   B 1 299 ? 20.80416  17.47363  18.20263  1.000 25.16503 ? 278 ASN   B ND2 1 
ATOM   4994 N N   . GLY   B 1 300 ? 16.72089  17.28816  14.49246  1.000 14.47620 ? 279 GLY   B N   1 
ATOM   4995 C CA  . GLY   B 1 300 ? 16.27613  17.41507  13.11507  1.000 13.32389 ? 279 GLY   B CA  1 
ATOM   4996 C C   . GLY   B 1 300 ? 14.93777  18.11796  12.99140  1.000 20.04961 ? 279 GLY   B C   1 
ATOM   4997 O O   . GLY   B 1 300 ? 14.73381  18.92642  12.08107  1.000 21.63876 ? 279 GLY   B O   1 
ATOM   4998 N N   . LEU   B 1 301 ? 14.00318  17.81267  13.89387  1.000 13.15074 ? 280 LEU   B N   1 
ATOM   4999 C CA  . LEU   B 1 301 ? 12.70158  18.47257  13.85991  1.000 13.38905 ? 280 LEU   B CA  1 
ATOM   5000 C C   . LEU   B 1 301 ? 12.83730  19.96547  14.13322  1.000 12.20486 ? 280 LEU   B C   1 
ATOM   5001 O O   . LEU   B 1 301 ? 12.25809  20.79555  13.42313  1.000 16.03574 ? 280 LEU   B O   1 
ATOM   5002 C CB  . LEU   B 1 301 ? 11.76009  17.82239  14.87408  1.000 8.15477  ? 280 LEU   B CB  1 
ATOM   5003 C CG  . LEU   B 1 301 ? 10.35126  18.40897  14.97815  1.000 10.51578 ? 280 LEU   B CG  1 
ATOM   5004 C CD1 . LEU   B 1 301 ? 9.60244   18.26923  13.66191  1.000 9.76440  ? 280 LEU   B CD1 1 
ATOM   5005 C CD2 . LEU   B 1 301 ? 9.58508   17.74165  16.10690  1.000 9.98864  ? 280 LEU   B CD2 1 
ATOM   5006 N N   . LEU   B 1 302 ? 13.60908  20.32595  15.16063  1.000 13.48008 ? 281 LEU   B N   1 
ATOM   5007 C CA  . LEU   B 1 302 ? 13.75985  21.73387  15.51297  1.000 17.49267 ? 281 LEU   B CA  1 
ATOM   5008 C C   . LEU   B 1 302 ? 14.50586  22.50585  14.42921  1.000 21.71287 ? 281 LEU   B C   1 
ATOM   5009 O O   . LEU   B 1 302 ? 14.10941  23.62159  14.07202  1.000 21.20973 ? 281 LEU   B O   1 
ATOM   5010 C CB  . LEU   B 1 302 ? 14.47424  21.85719  16.85710  1.000 21.15703 ? 281 LEU   B CB  1 
ATOM   5011 C CG  . LEU   B 1 302 ? 13.68816  21.32806  18.05792  1.000 19.48030 ? 281 LEU   B CG  1 
ATOM   5012 C CD1 . LEU   B 1 302 ? 14.51244  21.43344  19.32952  1.000 21.94947 ? 281 LEU   B CD1 1 
ATOM   5013 C CD2 . LEU   B 1 302 ? 12.36460  22.06103  18.20912  1.000 20.42417 ? 281 LEU   B CD2 1 
ATOM   5014 N N   . ALA   B 1 303 ? 15.58326  21.92754  13.89048  1.000 16.85547 ? 282 ALA   B N   1 
ATOM   5015 C CA  . ALA   B 1 303 ? 16.37083  22.62632  12.87856  1.000 20.13405 ? 282 ALA   B CA  1 
ATOM   5016 C C   . ALA   B 1 303 ? 15.56321  22.85850  11.60891  1.000 21.35068 ? 282 ALA   B C   1 
ATOM   5017 O O   . ALA   B 1 303 ? 15.63762  23.93543  11.00518  1.000 15.37340 ? 282 ALA   B O   1 
ATOM   5018 C CB  . ALA   B 1 303 ? 17.64557  21.84290  12.56668  1.000 19.50916 ? 282 ALA   B CB  1 
ATOM   5019 N N   . ASP   B 1 304 ? 14.78242  21.86065  11.18848  1.000 24.84278 ? 283 ASP   B N   1 
ATOM   5020 C CA  . ASP   B 1 304 ? 13.96112  22.00010  9.99302   1.000 20.78527 ? 283 ASP   B CA  1 
ATOM   5021 C C   . ASP   B 1 304 ? 12.84982  23.02685  10.16073  1.000 18.29133 ? 283 ASP   B C   1 
ATOM   5022 O O   . ASP   B 1 304 ? 12.25549  23.43927  9.15840   1.000 20.30155 ? 283 ASP   B O   1 
ATOM   5023 C CB  . ASP   B 1 304 ? 13.36461  20.64554  9.60566   1.000 24.02565 ? 283 ASP   B CB  1 
ATOM   5024 C CG  . ASP   B 1 304 ? 14.41115  19.66984  9.10416   1.000 28.42645 ? 283 ASP   B CG  1 
ATOM   5025 O OD1 . ASP   B 1 304 ? 15.55898  20.09890  8.85730   1.000 25.88870 ? 283 ASP   B OD1 1 
ATOM   5026 O OD2 . ASP   B 1 304 ? 14.08562  18.47305  8.95671   1.000 30.55870 ? 283 ASP   B OD2 1 
ATOM   5027 N N   . ASN   B 1 305 ? 12.55059  23.43835  11.39186  1.000 19.74788 ? 284 ASN   B N   1 
ATOM   5028 C CA  . ASN   B 1 305 ? 11.60729  24.51670  11.65322  1.000 16.65578 ? 284 ASN   B CA  1 
ATOM   5029 C C   . ASN   B 1 305 ? 12.29861  25.79124  12.12714  1.000 20.47489 ? 284 ASN   B C   1 
ATOM   5030 O O   . ASN   B 1 305 ? 11.62270  26.70843  12.60687  1.000 24.91656 ? 284 ASN   B O   1 
ATOM   5031 C CB  . ASN   B 1 305 ? 10.55859  24.06788  12.67386  1.000 17.76492 ? 284 ASN   B CB  1 
ATOM   5032 C CG  . ASN   B 1 305 ? 9.58951   23.04129  12.10434  1.000 20.71532 ? 284 ASN   B CG  1 
ATOM   5033 O OD1 . ASN   B 1 305 ? 8.56430   23.39527  11.52022  1.000 18.32402 ? 284 ASN   B OD1 1 
ATOM   5034 N ND2 . ASN   B 1 305 ? 9.91186   21.76388  12.27256  1.000 16.10329 ? 284 ASN   B ND2 1 
ATOM   5035 N N   . ASN   B 1 306 ? 13.62661  25.86945  11.99276  1.000 23.27356 ? 285 ASN   B N   1 
ATOM   5036 C CA  . ASN   B 1 306 ? 14.41130  27.04676  12.38024  1.000 21.73509 ? 285 ASN   B CA  1 
ATOM   5037 C C   . ASN   B 1 306 ? 14.18749  27.41876  13.84472  1.000 21.76707 ? 285 ASN   B C   1 
ATOM   5038 O O   . ASN   B 1 306 ? 14.04910  28.59274  14.19343  1.000 22.57552 ? 285 ASN   B O   1 
ATOM   5039 C CB  . ASN   B 1 306 ? 14.11569  28.23761  11.46477  1.000 32.46798 ? 285 ASN   B CB  1 
ATOM   5040 C CG  . ASN   B 1 306 ? 14.02510  27.84125  10.00353  1.000 39.12533 ? 285 ASN   B CG  1 
ATOM   5041 O OD1 . ASN   B 1 306 ? 14.90186  27.15112  9.47978   1.000 38.21613 ? 285 ASN   B OD1 1 
ATOM   5042 N ND2 . ASN   B 1 306 ? 12.96152  28.27566  9.33700   1.000 40.16427 ? 285 ASN   B ND2 1 
ATOM   5043 N N   . ILE   B 1 307 ? 14.16656  26.40780  14.70846  1.000 22.04069 ? 286 ILE   B N   1 
ATOM   5044 C CA  . ILE   B 1 307 ? 14.00738  26.57803  16.14737  1.000 21.52359 ? 286 ILE   B CA  1 
ATOM   5045 C C   . ILE   B 1 307 ? 15.20176  25.92770  16.83114  1.000 25.85187 ? 286 ILE   B C   1 
ATOM   5046 O O   . ILE   B 1 307 ? 15.60940  24.82287  16.45430  1.000 26.37672 ? 286 ILE   B O   1 
ATOM   5047 C CB  . ILE   B 1 307 ? 12.68645  25.96143  16.64839  1.000 20.38477 ? 286 ILE   B CB  1 
ATOM   5048 C CG1 . ILE   B 1 307 ? 11.48996  26.83857  16.27002  1.000 31.43988 ? 286 ILE   B CG1 1 
ATOM   5049 C CG2 . ILE   B 1 307 ? 12.71520  25.76113  18.15754  1.000 27.26844 ? 286 ILE   B CG2 1 
ATOM   5050 C CD1 . ILE   B 1 307 ? 11.75866  28.32499  16.33313  1.000 39.44667 ? 286 ILE   B CD1 1 
ATOM   5051 N N   . GLU   B 1 308 ? 15.78478  26.62529  17.80340  1.000 24.64793 ? 287 GLU   B N   1 
ATOM   5052 C CA  . GLU   B 1 308 ? 16.79420  26.04245  18.67652  1.000 29.20744 ? 287 GLU   B CA  1 
ATOM   5053 C C   . GLU   B 1 308 ? 16.14934  25.57686  19.97305  1.000 27.60041 ? 287 GLU   B C   1 
ATOM   5054 O O   . GLU   B 1 308 ? 15.21807  26.21001  20.47972  1.000 24.60514 ? 287 GLU   B O   1 
ATOM   5055 C CB  . GLU   B 1 308 ? 17.92487  27.02606  18.98994  1.000 34.31464 ? 287 GLU   B CB  1 
ATOM   5056 C CG  . GLU   B 1 308 ? 18.88275  27.34590  17.83494  1.000 38.13464 ? 287 GLU   B CG  1 
ATOM   5057 C CD  . GLU   B 1 308 ? 18.29149  28.25288  16.76844  1.000 49.04318 ? 287 GLU   B CD  1 
ATOM   5058 O OE1 . GLU   B 1 308 ? 18.90211  29.30643  16.48839  1.000 52.76116 ? 287 GLU   B OE1 1 
ATOM   5059 O OE2 . GLU   B 1 308 ? 17.24199  27.91443  16.18539  1.000 54.39961 ? 287 GLU   B OE2 1 
ATOM   5060 N N   . SER   B 1 309 ? 16.67200  24.47543  20.51774  1.000 32.13430 ? 288 SER   B N   1 
ATOM   5061 C CA  . SER   B 1 309 ? 16.04455  23.84747  21.67521  1.000 29.88710 ? 288 SER   B CA  1 
ATOM   5062 C C   . SER   B 1 309 ? 16.05190  24.75856  22.89530  1.000 30.35747 ? 288 SER   B C   1 
ATOM   5063 O O   . SER   B 1 309 ? 15.15933  24.65899  23.74370  1.000 29.81245 ? 288 SER   B O   1 
ATOM   5064 C CB  . SER   B 1 309 ? 16.74007  22.52278  21.99073  1.000 34.56056 ? 288 SER   B CB  1 
ATOM   5065 O OG  . SER   B 1 309 ? 18.12500  22.70773  22.21463  1.000 35.65216 ? 288 SER   B OG  1 
ATOM   5066 N N   . GLU   B 1 310 ? 17.04122  25.64933  23.00480  1.000 38.83034 ? 289 GLU   B N   1 
ATOM   5067 C CA  . GLU   B 1 310 ? 17.09333  26.56259  24.14045  1.000 34.47684 ? 289 GLU   B CA  1 
ATOM   5068 C C   . GLU   B 1 310 ? 15.95357  27.57448  24.12622  1.000 36.18211 ? 289 GLU   B C   1 
ATOM   5069 O O   . GLU   B 1 310 ? 15.63435  28.14280  25.17536  1.000 33.54990 ? 289 GLU   B O   1 
ATOM   5070 C CB  . GLU   B 1 310 ? 18.43762  27.29407  24.17091  1.000 38.06335 ? 289 GLU   B CB  1 
ATOM   5071 C CG  . GLU   B 1 310 ? 18.88432  27.85432  22.82538  1.000 42.15141 ? 289 GLU   B CG  1 
ATOM   5072 C CD  . GLU   B 1 310 ? 19.87643  26.95601  22.10453  1.000 41.28577 ? 289 GLU   B CD  1 
ATOM   5073 O OE1 . GLU   B 1 310 ? 19.87064  25.73118  22.35079  1.000 35.76814 ? 289 GLU   B OE1 1 
ATOM   5074 O OE2 . GLU   B 1 310 ? 20.66775  27.47996  21.29069  1.000 42.81897 ? 289 GLU   B OE2 1 
ATOM   5075 N N   . ASN   B 1 311 ? 15.33375  27.81081  22.97242  1.000 34.06456 ? 290 ASN   B N   1 
ATOM   5076 C CA  . ASN   B 1 311 ? 14.23217  28.75760  22.86801  1.000 31.35785 ? 290 ASN   B CA  1 
ATOM   5077 C C   . ASN   B 1 311 ? 12.86748  28.10771  23.05494  1.000 29.77718 ? 290 ASN   B C   1 
ATOM   5078 O O   . ASN   B 1 311 ? 11.84986  28.80155  22.95611  1.000 25.56994 ? 290 ASN   B O   1 
ATOM   5079 C CB  . ASN   B 1 311 ? 14.28203  29.48118  21.51893  1.000 27.91378 ? 290 ASN   B CB  1 
ATOM   5080 C CG  . ASN   B 1 311 ? 15.51581  30.34861  21.37144  1.000 37.65800 ? 290 ASN   B CG  1 
ATOM   5081 O OD1 . ASN   B 1 311 ? 16.15111  30.71613  22.36081  1.000 34.76272 ? 290 ASN   B OD1 1 
ATOM   5082 N ND2 . ASN   B 1 311 ? 15.85968  30.68491  20.13321  1.000 34.91082 ? 290 ASN   B ND2 1 
ATOM   5083 N N   . LEU   B 1 312 ? 12.81915  26.80428  23.31966  1.000 27.34296 ? 291 LEU   B N   1 
ATOM   5084 C CA  . LEU   B 1 312 ? 11.55283  26.14782  23.61252  1.000 17.87892 ? 291 LEU   B CA  1 
ATOM   5085 C C   . LEU   B 1 312 ? 11.00026  26.65602  24.93803  1.000 20.41398 ? 291 LEU   B C   1 
ATOM   5086 O O   . LEU   B 1 312 ? 11.70351  26.66885  25.95306  1.000 21.81117 ? 291 LEU   B O   1 
ATOM   5087 C CB  . LEU   B 1 312 ? 11.73934  24.63092  23.65879  1.000 22.09030 ? 291 LEU   B CB  1 
ATOM   5088 C CG  . LEU   B 1 312 ? 11.74154  23.89479  22.31556  1.000 17.16502 ? 291 LEU   B CG  1 
ATOM   5089 C CD1 . LEU   B 1 312 ? 12.07540  22.42291  22.50330  1.000 14.81290 ? 291 LEU   B CD1 1 
ATOM   5090 C CD2 . LEU   B 1 312 ? 10.39476  24.05126  21.62386  1.000 18.53685 ? 291 LEU   B CD2 1 
ATOM   5091 N N   . TYR   B 1 313 ? 9.73832   27.08609  24.92480  1.000 16.23074 ? 292 TYR   B N   1 
ATOM   5092 C CA  . TYR   B 1 313 ? 9.11756   27.59840  26.13883  1.000 15.32042 ? 292 TYR   B CA  1 
ATOM   5093 C C   . TYR   B 1 313 ? 8.67527   26.48317  27.07579  1.000 19.01902 ? 292 TYR   B C   1 
ATOM   5094 O O   . TYR   B 1 313 ? 8.62101   26.68913  28.29372  1.000 16.18957 ? 292 TYR   B O   1 
ATOM   5095 C CB  . TYR   B 1 313 ? 7.92487   28.48801  25.78406  1.000 24.45289 ? 292 TYR   B CB  1 
ATOM   5096 C CG  . TYR   B 1 313 ? 7.20934   29.05788  26.98841  1.000 28.47046 ? 292 TYR   B CG  1 
ATOM   5097 C CD1 . TYR   B 1 313 ? 7.67571   30.20484  27.61747  1.000 27.14599 ? 292 TYR   B CD1 1 
ATOM   5098 C CD2 . TYR   B 1 313 ? 6.06269   28.45521  27.48953  1.000 26.16039 ? 292 TYR   B CD2 1 
ATOM   5099 C CE1 . TYR   B 1 313 ? 7.02878   30.72857  28.71814  1.000 37.52268 ? 292 TYR   B CE1 1 
ATOM   5100 C CE2 . TYR   B 1 313 ? 5.40836   28.97202  28.58955  1.000 33.73325 ? 292 TYR   B CE2 1 
ATOM   5101 C CZ  . TYR   B 1 313 ? 5.89518   30.10860  29.20034  1.000 38.31891 ? 292 TYR   B CZ  1 
ATOM   5102 O OH  . TYR   B 1 313 ? 5.24444   30.62831  30.29593  1.000 45.50168 ? 292 TYR   B OH  1 
ATOM   5103 N N   . ARG   B 1 314 ? 8.36776   25.30501  26.53943  1.000 20.46572 ? 293 ARG   B N   1 
ATOM   5104 C CA  . ARG   B 1 314 ? 7.73661   24.25799  27.32656  1.000 23.05413 ? 293 ARG   B CA  1 
ATOM   5105 C C   . ARG   B 1 314 ? 8.04819   22.89319  26.73409  1.000 16.86069 ? 293 ARG   B C   1 
ATOM   5106 O O   . ARG   B 1 314 ? 7.99190   22.71139  25.51583  1.000 13.92465 ? 293 ARG   B O   1 
ATOM   5107 C CB  . ARG   B 1 314 ? 6.22056   24.46337  27.37886  1.000 16.89209 ? 293 ARG   B CB  1 
ATOM   5108 C CG  . ARG   B 1 314 ? 5.47120   23.40319  28.15254  1.000 26.53344 ? 293 ARG   B CG  1 
ATOM   5109 C CD  . ARG   B 1 314 ? 3.97638   23.62077  28.03251  1.000 23.39319 ? 293 ARG   B CD  1 
ATOM   5110 N NE  . ARG   B 1 314 ? 3.51700   24.67958  28.92307  1.000 34.02866 ? 293 ARG   B NE  1 
ATOM   5111 C CZ  . ARG   B 1 314 ? 3.07455   25.86199  28.51656  1.000 32.23523 ? 293 ARG   B CZ  1 
ATOM   5112 N NH1 . ARG   B 1 314 ? 3.02159   26.17619  27.23222  1.000 25.44550 ? 293 ARG   B NH1 1 
ATOM   5113 N NH2 . ARG   B 1 314 ? 2.67284   26.75086  29.42143  1.000 21.92210 ? 293 ARG   B NH2 1 
ATOM   5114 N N   . TRP   B 1 315 ? 8.35535   21.93749  27.60661  1.000 8.52511  ? 294 TRP   B N   1 
ATOM   5115 C CA  . TRP   B 1 315 ? 8.51101   20.53876  27.23473  1.000 11.97050 ? 294 TRP   B CA  1 
ATOM   5116 C C   . TRP   B 1 315 ? 7.39765   19.71712  27.87224  1.000 11.60442 ? 294 TRP   B C   1 
ATOM   5117 O O   . TRP   B 1 315 ? 7.02814   19.94865  29.02731  1.000 13.68444 ? 294 TRP   B O   1 
ATOM   5118 C CB  . TRP   B 1 315 ? 9.86763   19.98599  27.68128  1.000 14.05930 ? 294 TRP   B CB  1 
ATOM   5119 C CG  . TRP   B 1 315 ? 11.06530  20.54373  26.96172  1.000 17.06247 ? 294 TRP   B CG  1 
ATOM   5120 C CD1 . TRP   B 1 315 ? 11.50319  21.83684  26.96886  1.000 20.03247 ? 294 TRP   B CD1 1 
ATOM   5121 C CD2 . TRP   B 1 315 ? 11.99557  19.81074  26.15408  1.000 15.15902 ? 294 TRP   B CD2 1 
ATOM   5122 N NE1 . TRP   B 1 315 ? 12.64369  21.95563  26.20980  1.000 15.23970 ? 294 TRP   B NE1 1 
ATOM   5123 C CE2 . TRP   B 1 315 ? 12.96538  20.72653  25.69706  1.000 17.13752 ? 294 TRP   B CE2 1 
ATOM   5124 C CE3 . TRP   B 1 315 ? 12.09813  18.47047  25.76731  1.000 16.91758 ? 294 TRP   B CE3 1 
ATOM   5125 C CZ2 . TRP   B 1 315 ? 14.02290  20.34571  24.87075  1.000 17.16194 ? 294 TRP   B CZ2 1 
ATOM   5126 C CZ3 . TRP   B 1 315 ? 13.14923  18.09369  24.94724  1.000 17.67602 ? 294 TRP   B CZ3 1 
ATOM   5127 C CH2 . TRP   B 1 315 ? 14.09840  19.02823  24.51031  1.000 14.69382 ? 294 TRP   B CH2 1 
ATOM   5128 N N   . ILE   B 1 316 ? 6.86309   18.76099  27.11475  1.000 11.45240 ? 295 ILE   B N   1 
ATOM   5129 C CA  . ILE   B 1 316 ? 5.85621   17.82043  27.60902  1.000 12.54869 ? 295 ILE   B CA  1 
ATOM   5130 C C   . ILE   B 1 316 ? 6.37830   16.42643  27.26886  1.000 9.41153  ? 295 ILE   B C   1 
ATOM   5131 O O   . ILE   B 1 316 ? 6.12831   15.90203  26.17996  1.000 9.60098  ? 295 ILE   B O   1 
ATOM   5132 C CB  . ILE   B 1 316 ? 4.47213   18.05948  26.99708  1.000 8.30742  ? 295 ILE   B CB  1 
ATOM   5133 C CG1 . ILE   B 1 316 ? 4.00964   19.49642  27.25225  1.000 10.28641 ? 295 ILE   B CG1 1 
ATOM   5134 C CG2 . ILE   B 1 316 ? 3.45824   17.06746  27.55915  1.000 10.83364 ? 295 ILE   B CG2 1 
ATOM   5135 C CD1 . ILE   B 1 316 ? 2.73834   19.87118  26.50901  1.000 10.20644 ? 295 ILE   B CD1 1 
ATOM   5136 N N   . VAL   B 1 317 ? 7.09766   15.81088  28.20465  1.000 7.72429  ? 296 VAL   B N   1 
ATOM   5137 C CA  . VAL   B 1 317 ? 7.84117   14.58050  27.95077  1.000 8.89590  ? 296 VAL   B CA  1 
ATOM   5138 C C   . VAL   B 1 317 ? 7.19355   13.43663  28.71464  1.000 8.48319  ? 296 VAL   B C   1 
ATOM   5139 O O   . VAL   B 1 317 ? 7.05713   13.50156  29.94261  1.000 8.40834  ? 296 VAL   B O   1 
ATOM   5140 C CB  . VAL   B 1 317 ? 9.32087   14.73046  28.34530  1.000 10.55829 ? 296 VAL   B CB  1 
ATOM   5141 C CG1 . VAL   B 1 317 ? 10.07000  13.42736  28.11354  1.000 10.60694 ? 296 VAL   B CG1 1 
ATOM   5142 C CG2 . VAL   B 1 317 ? 9.95919   15.86468  27.55773  1.000 7.04556  ? 296 VAL   B CG2 1 
ATOM   5143 N N   . HIS   B 1 318 ? 6.82399   12.38088  27.99248  1.000 6.51457  ? 297 HIS   B N   1 
ATOM   5144 C CA  . HIS   B 1 318 ? 6.23230   11.21307  28.62987  1.000 11.06856 ? 297 HIS   B CA  1 
ATOM   5145 C C   . HIS   B 1 318 ? 7.20031   10.63825  29.65794  1.000 10.43369 ? 297 HIS   B C   1 
ATOM   5146 O O   . HIS   B 1 318 ? 8.36204   10.36550  29.32282  1.000 7.79332  ? 297 HIS   B O   1 
ATOM   5147 C CB  . HIS   B 1 318 ? 5.89230   10.14084  27.59680  1.000 10.86808 ? 297 HIS   B CB  1 
ATOM   5148 C CG  . HIS   B 1 318 ? 5.54497   8.81636   28.20126  1.000 11.17901 ? 297 HIS   B CG  1 
ATOM   5149 N ND1 . HIS   B 1 318 ? 4.31928   8.56120   28.77638  1.000 10.59474 ? 297 HIS   B ND1 1 
ATOM   5150 C CD2 . HIS   B 1 318 ? 6.26551   7.67720   28.33086  1.000 13.29312 ? 297 HIS   B CD2 1 
ATOM   5151 C CE1 . HIS   B 1 318 ? 4.29593   7.31908   29.22702  1.000 14.48875 ? 297 HIS   B CE1 1 
ATOM   5152 N NE2 . HIS   B 1 318 ? 5.46535   6.76107   28.97029  1.000 12.03149 ? 297 HIS   B NE2 1 
ATOM   5153 N N   . PRO   B 1 319 ? 6.77126   10.44356  30.90966  1.000 10.93573 ? 298 PRO   B N   1 
ATOM   5154 C CA  . PRO   B 1 319 ? 7.63562   9.86391   31.95239  1.000 14.40841 ? 298 PRO   B CA  1 
ATOM   5155 C C   . PRO   B 1 319 ? 7.61225   8.33602   31.98277  1.000 15.19081 ? 298 PRO   B C   1 
ATOM   5156 O O   . PRO   B 1 319 ? 6.96861   7.69462   32.81867  1.000 20.96274 ? 298 PRO   B O   1 
ATOM   5157 C CB  . PRO   B 1 319 ? 7.04723   10.45714  33.23231  1.000 13.18212 ? 298 PRO   B CB  1 
ATOM   5158 C CG  . PRO   B 1 319 ? 5.57225   10.50915  32.93631  1.000 11.86846 ? 298 PRO   B CG  1 
ATOM   5159 C CD  . PRO   B 1 319 ? 5.44265   10.79319  31.44556  1.000 10.15797 ? 298 PRO   B CD  1 
ATOM   5160 N N   . GLY   B 1 320 ? 8.33190   7.72682   31.03903  1.000 12.93309 ? 299 GLY   B N   1 
ATOM   5161 C CA  . GLY   B 1 320 ? 8.49600   6.28453   31.07624  1.000 19.47224 ? 299 GLY   B CA  1 
ATOM   5162 C C   . GLY   B 1 320 ? 9.08877   5.81288   32.38755  1.000 25.37534 ? 299 GLY   B C   1 
ATOM   5163 O O   . GLY   B 1 320 ? 8.76464   4.72400   32.86734  1.000 25.91286 ? 299 GLY   B O   1 
ATOM   5164 N N   . GLY   B 1 321 ? 9.94767   6.63110   32.98862  1.000 26.35519 ? 300 GLY   B N   1 
ATOM   5165 C CA  . GLY   B 1 321 ? 10.49247  6.38314   34.30032  1.000 21.36181 ? 300 GLY   B CA  1 
ATOM   5166 C C   . GLY   B 1 321 ? 11.30419  7.57893   34.75388  1.000 20.06927 ? 300 GLY   B C   1 
ATOM   5167 O O   . GLY   B 1 321 ? 11.57011  8.49865   33.97348  1.000 20.88291 ? 300 GLY   B O   1 
ATOM   5168 N N   . PRO   B 1 322 ? 11.69736  7.60815   36.02971  1.000 21.02224 ? 301 PRO   B N   1 
ATOM   5169 C CA  . PRO   B 1 322 ? 12.57923  8.69802   36.48249  1.000 13.67572 ? 301 PRO   B CA  1 
ATOM   5170 C C   . PRO   B 1 322 ? 13.90665  8.72578   35.74650  1.000 22.72199 ? 301 PRO   B C   1 
ATOM   5171 O O   . PRO   B 1 322 ? 14.45103  9.81117   35.50599  1.000 18.97870 ? 301 PRO   B O   1 
ATOM   5172 C CB  . PRO   B 1 322 ? 12.76289  8.42241   37.98331  1.000 17.53765 ? 301 PRO   B CB  1 
ATOM   5173 C CG  . PRO   B 1 322 ? 12.26790  7.03640   38.21988  1.000 26.82300 ? 301 PRO   B CG  1 
ATOM   5174 C CD  . PRO   B 1 322 ? 11.35557  6.65586   37.10039  1.000 24.67812 ? 301 PRO   B CD  1 
ATOM   5175 N N   . LYS   B 1 323 ? 14.43931  7.55710   35.37874  1.000 25.16242 ? 302 LYS   B N   1 
ATOM   5176 C CA  . LYS   B 1 323 ? 15.67593  7.50082   34.60531  1.000 18.14109 ? 302 LYS   B CA  1 
ATOM   5177 C C   . LYS   B 1 323 ? 15.48628  8.09707   33.21601  1.000 23.32082 ? 302 LYS   B C   1 
ATOM   5178 O O   . LYS   B 1 323 ? 16.38345  8.76767   32.68947  1.000 18.44996 ? 302 LYS   B O   1 
ATOM   5179 C CB  . LYS   B 1 323 ? 16.15545  6.05350   34.50980  1.000 26.74935 ? 302 LYS   B CB  1 
ATOM   5180 C CG  . LYS   B 1 323 ? 17.63750  5.86311   34.77130  1.000 32.05358 ? 302 LYS   B CG  1 
ATOM   5181 C CD  . LYS   B 1 323 ? 18.16204  4.62055   34.07014  1.000 36.18554 ? 302 LYS   B CD  1 
ATOM   5182 C CE  . LYS   B 1 323 ? 19.67907  4.63565   33.97736  1.000 38.79581 ? 302 LYS   B CE  1 
ATOM   5183 N NZ  . LYS   B 1 323 ? 20.17807  5.71164   33.07476  1.000 38.66691 ? 302 LYS   B NZ  1 
ATOM   5184 N N   . VAL   B 1 324 ? 14.32893  7.84918   32.60203  1.000 18.03129 ? 303 VAL   B N   1 
ATOM   5185 C CA  . VAL   B 1 324 ? 14.03986  8.42424   31.29244  1.000 18.46706 ? 303 VAL   B CA  1 
ATOM   5186 C C   . VAL   B 1 324 ? 14.00843  9.94512   31.37354  1.000 14.07937 ? 303 VAL   B C   1 
ATOM   5187 O O   . VAL   B 1 324 ? 14.55902  10.63928  30.50969  1.000 12.52732 ? 303 VAL   B O   1 
ATOM   5188 C CB  . VAL   B 1 324 ? 12.71780  7.85535   30.74641  1.000 11.76298 ? 303 VAL   B CB  1 
ATOM   5189 C CG1 . VAL   B 1 324 ? 12.25687  8.64571   29.53533  1.000 19.28553 ? 303 VAL   B CG1 1 
ATOM   5190 C CG2 . VAL   B 1 324 ? 12.88103  6.38421   30.40429  1.000 12.38856 ? 303 VAL   B CG2 1 
ATOM   5191 N N   . ILE   B 1 325 ? 13.36885  10.48832  32.41270  1.000 14.64986 ? 304 ILE   B N   1 
ATOM   5192 C CA  . ILE   B 1 325 ? 13.32569  11.93993  32.57426  1.000 13.31032 ? 304 ILE   B CA  1 
ATOM   5193 C C   . ILE   B 1 325 ? 14.73440  12.49621  32.73797  1.000 11.77560 ? 304 ILE   B C   1 
ATOM   5194 O O   . ILE   B 1 325 ? 15.09949  13.49906  32.11099  1.000 13.70877 ? 304 ILE   B O   1 
ATOM   5195 C CB  . ILE   B 1 325 ? 12.42166  12.32417  33.76069  1.000 13.13721 ? 304 ILE   B CB  1 
ATOM   5196 C CG1 . ILE   B 1 325 ? 10.98793  11.85652  33.51271  1.000 18.15095 ? 304 ILE   B CG1 1 
ATOM   5197 C CG2 . ILE   B 1 325 ? 12.43211  13.83099  33.96990  1.000 10.66221 ? 304 ILE   B CG2 1 
ATOM   5198 C CD1 . ILE   B 1 325 ? 10.16373  11.72235  34.77670  1.000 11.38701 ? 304 ILE   B CD1 1 
ATOM   5199 N N   . ASP   B 1 326 ? 15.55442  11.84227  33.56563  1.000 20.89328 ? 305 ASP   B N   1 
ATOM   5200 C CA  . ASP   B 1 326 ? 16.93626  12.27969  33.73960  1.000 15.00065 ? 305 ASP   B CA  1 
ATOM   5201 C C   . ASP   B 1 326 ? 17.68813  12.25944  32.41449  1.000 14.85424 ? 305 ASP   B C   1 
ATOM   5202 O O   . ASP   B 1 326 ? 18.42937  13.19741  32.09685  1.000 15.53347 ? 305 ASP   B O   1 
ATOM   5203 C CB  . ASP   B 1 326 ? 17.64587  11.39057  34.76335  1.000 16.56024 ? 305 ASP   B CB  1 
ATOM   5204 C CG  . ASP   B 1 326 ? 17.02736  11.47461  36.14717  1.000 18.98993 ? 305 ASP   B CG  1 
ATOM   5205 O OD1 . ASP   B 1 326 ? 16.35345  12.48114  36.44682  1.000 24.75777 ? 305 ASP   B OD1 1 
ATOM   5206 O OD2 . ASP   B 1 326 ? 17.21896  10.52737  36.93778  1.000 22.38317 ? 305 ASP   B OD2 1 
ATOM   5207 N N   . THR   B 1 327 ? 17.50012  11.19901  31.62451  1.000 13.36946 ? 306 THR   B N   1 
ATOM   5208 C CA  . THR   B 1 327 ? 18.20594  11.07904  30.35173  1.000 18.83054 ? 306 THR   B CA  1 
ATOM   5209 C C   . THR   B 1 327 ? 17.82632  12.20109  29.39087  1.000 17.12149 ? 306 THR   B C   1 
ATOM   5210 O O   . THR   B 1 327 ? 18.69734  12.78718  28.73735  1.000 17.18135 ? 306 THR   B O   1 
ATOM   5211 C CB  . THR   B 1 327 ? 17.92237  9.71320   29.72452  1.000 20.97380 ? 306 THR   B CB  1 
ATOM   5212 O OG1 . THR   B 1 327 ? 18.49334  8.68193   30.54175  1.000 15.19084 ? 306 THR   B OG1 1 
ATOM   5213 C CG2 . THR   B 1 327 ? 18.50427  9.63105   28.31769  1.000 15.82467 ? 306 THR   B CG2 1 
ATOM   5214 N N   . VAL   B 1 328 ? 16.53246  12.51665  29.28854  1.000 16.16266 ? 307 VAL   B N   1 
ATOM   5215 C CA  . VAL   B 1 328 ? 16.11315  13.61705  28.42382  1.000 15.46146 ? 307 VAL   B CA  1 
ATOM   5216 C C   . VAL   B 1 328 ? 16.69855  14.92961  28.92535  1.000 14.18128 ? 307 VAL   B C   1 
ATOM   5217 O O   . VAL   B 1 328 ? 17.17947  15.75679  28.14108  1.000 14.31286 ? 307 VAL   B O   1 
ATOM   5218 C CB  . VAL   B 1 328 ? 14.57701  13.68015  28.33541  1.000 12.37409 ? 307 VAL   B CB  1 
ATOM   5219 C CG1 . VAL   B 1 328 ? 14.14047  14.92722  27.57718  1.000 12.83827 ? 307 VAL   B CG1 1 
ATOM   5220 C CG2 . VAL   B 1 328 ? 14.02684  12.42536  27.67989  1.000 15.66288 ? 307 VAL   B CG2 1 
ATOM   5221 N N   . GLU   B 1 329 ? 16.67523  15.13359  30.24293  1.000 14.81085 ? 308 GLU   B N   1 
ATOM   5222 C CA  . GLU   B 1 329 ? 17.23408  16.34848  30.82436  1.000 16.81823 ? 308 GLU   B CA  1 
ATOM   5223 C C   . GLU   B 1 329 ? 18.72015  16.47772  30.50809  1.000 15.46666 ? 308 GLU   B C   1 
ATOM   5224 O O   . GLU   B 1 329 ? 19.18781  17.55151  30.10996  1.000 16.87939 ? 308 GLU   B O   1 
ATOM   5225 C CB  . GLU   B 1 329 ? 16.99946  16.33727  32.33438  1.000 19.14049 ? 308 GLU   B CB  1 
ATOM   5226 C CG  . GLU   B 1 329 ? 17.16238  17.67222  33.02619  1.000 32.04198 ? 308 GLU   B CG  1 
ATOM   5227 C CD  . GLU   B 1 329 ? 16.88153  17.57645  34.51458  1.000 36.51310 ? 308 GLU   B CD  1 
ATOM   5228 O OE1 . GLU   B 1 329 ? 15.69103  17.55881  34.89767  1.000 33.60961 ? 308 GLU   B OE1 1 
ATOM   5229 O OE2 . GLU   B 1 329 ? 17.85206  17.51760  35.30037  1.000 40.35293 ? 308 GLU   B OE2 1 
ATOM   5230 N N   . ALA   B 1 330 ? 19.47201  15.38273  30.65424  1.000 15.99633 ? 309 ALA   B N   1 
ATOM   5231 C CA  . ALA   B 1 330 ? 20.91485  15.42456  30.43208  1.000 17.49941 ? 309 ALA   B CA  1 
ATOM   5232 C C   . ALA   B 1 330 ? 21.25502  15.59038  28.95558  1.000 19.80786 ? 309 ALA   B C   1 
ATOM   5233 O O   . ALA   B 1 330 ? 22.18978  16.32189  28.60819  1.000 19.85341 ? 309 ALA   B O   1 
ATOM   5234 C CB  . ALA   B 1 330 ? 21.56434  14.15711  30.98717  1.000 10.88456 ? 309 ALA   B CB  1 
ATOM   5235 N N   . GLU   B 1 331 ? 20.51344  14.91397  28.07450  1.000 16.12270 ? 310 GLU   B N   1 
ATOM   5236 C CA  . GLU   B 1 331 ? 20.83300  14.94317  26.64964  1.000 18.63098 ? 310 GLU   B CA  1 
ATOM   5237 C C   . GLU   B 1 331 ? 20.70878  16.34798  26.07115  1.000 19.26234 ? 310 GLU   B C   1 
ATOM   5238 O O   . GLU   B 1 331 ? 21.50055  16.74216  25.20705  1.000 19.85017 ? 310 GLU   B O   1 
ATOM   5239 C CB  . GLU   B 1 331 ? 19.93109  13.96987  25.89176  1.000 19.84857 ? 310 GLU   B CB  1 
ATOM   5240 C CG  . GLU   B 1 331 ? 20.33863  12.51313  26.01502  1.000 17.07207 ? 310 GLU   B CG  1 
ATOM   5241 C CD  . GLU   B 1 331 ? 21.56552  12.18575  25.18469  1.000 21.76366 ? 310 GLU   B CD  1 
ATOM   5242 O OE1 . GLU   B 1 331 ? 21.45229  12.17224  23.94031  1.000 20.68931 ? 310 GLU   B OE1 1 
ATOM   5243 O OE2 . GLU   B 1 331 ? 22.63851  11.94114  25.77341  1.000 25.18754 ? 310 GLU   B OE2 1 
ATOM   5244 N N   . PHE   B 1 332 ? 19.72075  17.11566  26.52408  1.000 13.00303 ? 311 PHE   B N   1 
ATOM   5245 C CA  . PHE   B 1 332 ? 19.47905  18.44859  25.99283  1.000 14.78003 ? 311 PHE   B CA  1 
ATOM   5246 C C   . PHE   B 1 332 ? 19.94553  19.55181  26.93133  1.000 15.43691 ? 311 PHE   B C   1 
ATOM   5247 O O   . PHE   B 1 332 ? 19.67077  20.72785  26.67079  1.000 16.73792 ? 311 PHE   B O   1 
ATOM   5248 C CB  . PHE   B 1 332 ? 17.99507  18.61383  25.66008  1.000 17.79799 ? 311 PHE   B CB  1 
ATOM   5249 C CG  . PHE   B 1 332 ? 17.53902  17.72892  24.54105  1.000 16.12299 ? 311 PHE   B CG  1 
ATOM   5250 C CD1 . PHE   B 1 332 ? 17.76362  18.08980  23.22365  1.000 22.80254 ? 311 PHE   B CD1 1 
ATOM   5251 C CD2 . PHE   B 1 332 ? 16.92842  16.51540  24.80440  1.000 12.20525 ? 311 PHE   B CD2 1 
ATOM   5252 C CE1 . PHE   B 1 332 ? 17.36220  17.27186  22.18783  1.000 20.46091 ? 311 PHE   B CE1 1 
ATOM   5253 C CE2 . PHE   B 1 332 ? 16.52331  15.69084  23.77220  1.000 21.99099 ? 311 PHE   B CE2 1 
ATOM   5254 C CZ  . PHE   B 1 332 ? 16.74509  16.06955  22.46223  1.000 20.51469 ? 311 PHE   B CZ  1 
ATOM   5255 N N   . GLY   B 1 333 ? 20.65357  19.20183  28.00169  1.000 16.87017 ? 312 GLY   B N   1 
ATOM   5256 C CA  . GLY   B 1 333 ? 21.16542  20.20009  28.93016  1.000 19.46505 ? 312 GLY   B CA  1 
ATOM   5257 C C   . GLY   B 1 333 ? 20.09005  21.05822  29.55820  1.000 21.77151 ? 312 GLY   B C   1 
ATOM   5258 O O   . GLY   B 1 333 ? 20.28005  22.26991  29.72185  1.000 20.94534 ? 312 GLY   B O   1 
ATOM   5259 N N   . LEU   B 1 334 ? 18.96207  20.45556  29.91881  1.000 20.27989 ? 313 LEU   B N   1 
ATOM   5260 C CA  . LEU   B 1 334 ? 17.82943  21.21154  30.42865  1.000 18.35273 ? 313 LEU   B CA  1 
ATOM   5261 C C   . LEU   B 1 334 ? 18.01404  21.54174  31.90261  1.000 25.33748 ? 313 LEU   B C   1 
ATOM   5262 O O   . LEU   B 1 334 ? 18.57598  20.75190  32.66749  1.000 25.05607 ? 313 LEU   B O   1 
ATOM   5263 C CB  . LEU   B 1 334 ? 16.53448  20.42423  30.23798  1.000 22.33671 ? 313 LEU   B CB  1 
ATOM   5264 C CG  . LEU   B 1 334 ? 16.24888  19.93632  28.81982  1.000 16.41776 ? 313 LEU   B CG  1 
ATOM   5265 C CD1 . LEU   B 1 334 ? 14.99254  19.07821  28.80202  1.000 16.25975 ? 313 LEU   B CD1 1 
ATOM   5266 C CD2 . LEU   B 1 334 ? 16.12461  21.11377  27.87243  1.000 16.30474 ? 313 LEU   B CD2 1 
ATOM   5267 N N   . ASP   B 1 335 ? 17.53738  22.72040  32.29604  1.000 28.44037 ? 314 ASP   B N   1 
ATOM   5268 C CA  . ASP   B 1 335 ? 17.44812  23.04414  33.71134  1.000 38.29023 ? 314 ASP   B CA  1 
ATOM   5269 C C   . ASP   B 1 335 ? 16.48779  22.07103  34.38519  1.000 37.42654 ? 314 ASP   B C   1 
ATOM   5270 O O   . ASP   B 1 335 ? 15.49550  21.64206  33.78970  1.000 31.83604 ? 314 ASP   B O   1 
ATOM   5271 C CB  . ASP   B 1 335 ? 16.97589  24.48653  33.89771  1.000 36.74135 ? 314 ASP   B CB  1 
ATOM   5272 C CG  . ASP   B 1 335 ? 18.01939  25.50468  33.48059  1.000 47.38035 ? 314 ASP   B CG  1 
ATOM   5273 O OD1 . ASP   B 1 335 ? 19.22652  25.19034  33.55659  1.000 52.14080 ? 314 ASP   B OD1 1 
ATOM   5274 O OD2 . ASP   B 1 335 ? 17.62996  26.62088  33.07625  1.000 50.50894 ? 314 ASP   B OD2 1 
ATOM   5275 N N   . SER   B 1 336 ? 16.78765  21.71021  35.62673  1.000 37.06912 ? 315 SER   B N   1 
ATOM   5276 C CA  . SER   B 1 336 ? 16.03965  20.58350  36.18453  1.000 41.32823 ? 315 SER   B CA  1 
ATOM   5277 C C   . SER   B 1 336 ? 14.58937  20.92929  36.59135  1.000 34.92506 ? 315 SER   B C   1 
ATOM   5278 O O   . SER   B 1 336 ? 13.96703  20.05695  37.21356  1.000 46.04623 ? 315 SER   B O   1 
ATOM   5279 C CB  . SER   B 1 336 ? 16.79774  19.98350  37.37155  1.000 33.85678 ? 315 SER   B CB  1 
ATOM   5280 O OG  . SER   B 1 336 ? 16.92215  20.90269  38.43518  1.000 44.90279 ? 315 SER   B OG  1 
ATOM   5281 N N   . GLN   B 1 337 ? 13.99725  22.08986  36.30707  1.000 32.17385 ? 316 GLN   B N   1 
ATOM   5282 C CA  . GLN   B 1 337 ? 12.56078  22.26705  36.48030  1.000 33.96131 ? 316 GLN   B CA  1 
ATOM   5283 C C   . GLN   B 1 337 ? 11.82256  22.25039  35.15010  1.000 27.40449 ? 316 GLN   B C   1 
ATOM   5284 O O   . GLN   B 1 337 ? 10.59149  22.35192  35.13371  1.000 22.27588 ? 316 GLN   B O   1 
ATOM   5285 C CB  . GLN   B 1 337 ? 12.24440  23.57266  37.22364  1.000 37.12697 ? 316 GLN   B CB  1 
ATOM   5286 C CG  . GLN   B 1 337 ? 12.20802  24.83638  36.36325  1.000 27.65647 ? 316 GLN   B CG  1 
ATOM   5287 C CD  . GLN   B 1 337 ? 13.56891  25.27663  35.87360  1.000 43.36809 ? 316 GLN   B CD  1 
ATOM   5288 O OE1 . GLN   B 1 337 ? 14.20303  24.58670  35.07750  1.000 50.30157 ? 316 GLN   B OE1 1 
ATOM   5289 N NE2 . GLN   B 1 337 ? 14.02367  26.43417  36.34105  1.000 37.70830 ? 316 GLN   B NE2 1 
ATOM   5290 N N   . THR   B 1 338 ? 12.54870  22.12516  34.03624  1.000 22.12727 ? 317 THR   B N   1 
ATOM   5291 C CA  . THR   B 1 338 ? 11.90648  22.11318  32.72618  1.000 26.74812 ? 317 THR   B CA  1 
ATOM   5292 C C   . THR   B 1 338 ? 11.00998  20.89100  32.56464  1.000 15.90629 ? 317 THR   B C   1 
ATOM   5293 O O   . THR   B 1 338 ? 9.93352   20.97696  31.96192  1.000 14.50350 ? 317 THR   B O   1 
ATOM   5294 C CB  . THR   B 1 338 ? 12.96623  22.15906  31.62441  1.000 23.11094 ? 317 THR   B CB  1 
ATOM   5295 O OG1 . THR   B 1 338 ? 13.68814  23.39585  31.70693  1.000 20.40491 ? 317 THR   B OG1 1 
ATOM   5296 C CG2 . THR   B 1 338 ? 12.31685  22.06979  30.25677  1.000 16.93126 ? 317 THR   B CG2 1 
ATOM   5297 N N   . LEU   B 1 339 ? 11.42611  19.74782  33.11382  1.000 14.34791 ? 318 LEU   B N   1 
ATOM   5298 C CA  . LEU   B 1 339 ? 10.64826  18.51684  33.05224  1.000 16.61999 ? 318 LEU   B CA  1 
ATOM   5299 C C   . LEU   B 1 339 ? 9.91112   18.22544  34.35417  1.000 14.63567 ? 318 LEU   B C   1 
ATOM   5300 O O   . LEU   B 1 339 ? 9.53523   17.07371  34.60021  1.000 11.48207 ? 318 LEU   B O   1 
ATOM   5301 C CB  . LEU   B 1 339 ? 11.54814  17.33338  32.69165  1.000 13.15880 ? 318 LEU   B CB  1 
ATOM   5302 C CG  . LEU   B 1 339 ? 12.32534  17.42662  31.37840  1.000 12.95865 ? 318 LEU   B CG  1 
ATOM   5303 C CD1 . LEU   B 1 339 ? 12.87286  16.06152  30.98774  1.000 14.59371 ? 318 LEU   B CD1 1 
ATOM   5304 C CD2 . LEU   B 1 339 ? 11.46107  18.01276  30.26950  1.000 16.04058 ? 318 LEU   B CD2 1 
ATOM   5305 N N   . GLN   B 1 340 ? 9.70229   19.24229  35.19496  1.000 13.45056 ? 319 GLN   B N   1 
ATOM   5306 C CA  . GLN   B 1 340 ? 9.03882   19.01499  36.47411  1.000 16.21490 ? 319 GLN   B CA  1 
ATOM   5307 C C   . GLN   B 1 340 ? 7.64344   18.43767  36.28480  1.000 11.64511 ? 319 GLN   B C   1 
ATOM   5308 O O   . GLN   B 1 340 ? 7.18879   17.63322  37.10494  1.000 11.57786 ? 319 GLN   B O   1 
ATOM   5309 C CB  . GLN   B 1 340 ? 8.97904   20.31747  37.27304  1.000 18.47659 ? 319 GLN   B CB  1 
ATOM   5310 C CG  . GLN   B 1 340 ? 8.54082   20.13983  38.71802  1.000 22.78218 ? 319 GLN   B CG  1 
ATOM   5311 C CD  . GLN   B 1 340 ? 9.46137   19.21949  39.49774  1.000 27.18911 ? 319 GLN   B CD  1 
ATOM   5312 O OE1 . GLN   B 1 340 ? 10.68383  19.28239  39.36417  1.000 32.03910 ? 319 GLN   B OE1 1 
ATOM   5313 N NE2 . GLN   B 1 340 ? 8.87568   18.35658  40.31710  1.000 22.51201 ? 319 GLN   B NE2 1 
ATOM   5314 N N   . LEU   B 1 341 ? 6.95981   18.81713  35.20290  1.000 13.69737 ? 320 LEU   B N   1 
ATOM   5315 C CA  . LEU   B 1 341 ? 5.63765   18.26413  34.93534  1.000 13.28309 ? 320 LEU   B CA  1 
ATOM   5316 C C   . LEU   B 1 341 ? 5.69369   16.75510  34.73022  1.000 9.72329  ? 320 LEU   B C   1 
ATOM   5317 O O   . LEU   B 1 341 ? 4.75431   16.04456  35.10500  1.000 10.35859 ? 320 LEU   B O   1 
ATOM   5318 C CB  . LEU   B 1 341 ? 5.02499   18.95346  33.71597  1.000 11.41559 ? 320 LEU   B CB  1 
ATOM   5319 C CG  . LEU   B 1 341 ? 3.64175   18.48365  33.26433  1.000 11.83782 ? 320 LEU   B CG  1 
ATOM   5320 C CD1 . LEU   B 1 341 ? 2.57161   18.90244  34.26466  1.000 11.34536 ? 320 LEU   B CD1 1 
ATOM   5321 C CD2 . LEU   B 1 341 ? 3.33783   19.02953  31.88143  1.000 13.46132 ? 320 LEU   B CD2 1 
ATOM   5322 N N   . SER   B 1 342 ? 6.78173   16.24741  34.14246  1.000 8.77469  ? 321 SER   B N   1 
ATOM   5323 C CA  . SER   B 1 342 ? 6.94049   14.80216  34.00117  1.000 10.76317 ? 321 SER   B CA  1 
ATOM   5324 C C   . SER   B 1 342 ? 7.02060   14.12169  35.36174  1.000 7.92372  ? 321 SER   B C   1 
ATOM   5325 O O   . SER   B 1 342 ? 6.41573   13.06405  35.57283  1.000 8.75089  ? 321 SER   B O   1 
ATOM   5326 C CB  . SER   B 1 342 ? 8.19187   14.48437  33.17846  1.000 7.16193  ? 321 SER   B CB  1 
ATOM   5327 O OG  . SER   B 1 342 ? 8.15675   15.12719  31.91711  1.000 7.79282  ? 321 SER   B OG  1 
ATOM   5328 N N   . ARG   B 1 343 ? 7.77205   14.71217  36.29493  1.000 7.35951  ? 322 ARG   B N   1 
ATOM   5329 C CA  . ARG   B 1 343 ? 7.91592   14.12378  37.62471  1.000 12.30753 ? 322 ARG   B CA  1 
ATOM   5330 C C   . ARG   B 1 343 ? 6.63289   14.24820  38.43720  1.000 12.28349 ? 322 ARG   B C   1 
ATOM   5331 O O   . ARG   B 1 343 ? 6.23979   13.30345  39.13250  1.000 9.38953  ? 322 ARG   B O   1 
ATOM   5332 C CB  . ARG   B 1 343 ? 9.07629   14.78330  38.36832  1.000 11.01193 ? 322 ARG   B CB  1 
ATOM   5333 C CG  . ARG   B 1 343 ? 10.42118  14.62436  37.68680  1.000 15.69901 ? 322 ARG   B CG  1 
ATOM   5334 C CD  . ARG   B 1 343 ? 11.53109  15.21316  38.53397  1.000 20.92083 ? 322 ARG   B CD  1 
ATOM   5335 N NE  . ARG   B 1 343 ? 12.49263  15.94435  37.72003  1.000 26.87233 ? 322 ARG   B NE  1 
ATOM   5336 C CZ  . ARG   B 1 343 ? 13.50664  15.38320  37.07698  1.000 28.68513 ? 322 ARG   B CZ  1 
ATOM   5337 N NH1 . ARG   B 1 343 ? 13.73254  14.08134  37.14427  1.000 31.62354 ? 322 ARG   B NH1 1 
ATOM   5338 N NH2 . ARG   B 1 343 ? 14.31125  16.14653  36.34366  1.000 37.40749 ? 322 ARG   B NH2 1 
ATOM   5339 N N   . ASP   B 1 344 ? 5.97872   15.41204  38.38574  1.000 11.13969 ? 323 ASP   B N   1 
ATOM   5340 C CA  . ASP   B 1 344 ? 4.72873   15.57371  39.12109  1.000 14.48877 ? 323 ASP   B CA  1 
ATOM   5341 C C   . ASP   B 1 344 ? 3.66956   14.60506  38.61633  1.000 9.88110  ? 323 ASP   B C   1 
ATOM   5342 O O   . ASP   B 1 344 ? 2.94441   14.00001  39.41207  1.000 12.47387 ? 323 ASP   B O   1 
ATOM   5343 C CB  . ASP   B 1 344 ? 4.22743   17.01588  39.02193  1.000 12.62830 ? 323 ASP   B CB  1 
ATOM   5344 C CG  . ASP   B 1 344 ? 5.17086   18.00796  39.66848  1.000 17.71205 ? 323 ASP   B CG  1 
ATOM   5345 O OD1 . ASP   B 1 344 ? 6.01107   17.57874  40.48778  1.000 14.55994 ? 323 ASP   B OD1 1 
ATOM   5346 O OD2 . ASP   B 1 344 ? 5.06827   19.21500  39.36385  1.000 13.28505 ? 323 ASP   B OD2 1 
ATOM   5347 N N   . THR   B 1 345 ? 3.57326   14.43498  37.29702  1.000 10.86804 ? 324 THR   B N   1 
ATOM   5348 C CA  . THR   B 1 345 ? 2.59658   13.50339  36.74186  1.000 10.57137 ? 324 THR   B CA  1 
ATOM   5349 C C   . THR   B 1 345 ? 2.86846   12.08176  37.21671  1.000 8.88591  ? 324 THR   B C   1 
ATOM   5350 O O   . THR   B 1 345 ? 1.95220   11.36875  37.64134  1.000 10.20673 ? 324 THR   B O   1 
ATOM   5351 C CB  . THR   B 1 345 ? 2.61919   13.58101  35.21687  1.000 8.62805  ? 324 THR   B CB  1 
ATOM   5352 O OG1 . THR   B 1 345 ? 2.16503   14.87549  34.80186  1.000 10.55927 ? 324 THR   B OG1 1 
ATOM   5353 C CG2 . THR   B 1 345 ? 1.73113   12.50335  34.61152  1.000 10.97864 ? 324 THR   B CG2 1 
ATOM   5354 N N   . LEU   B 1 346 ? 4.13599   11.66697  37.18390  1.000 10.51731 ? 325 LEU   B N   1 
ATOM   5355 C CA  . LEU   B 1 346 ? 4.49479   10.33053  37.64355  1.000 11.80189 ? 325 LEU   B CA  1 
ATOM   5356 C C   . LEU   B 1 346 ? 4.08852   10.12355  39.09789  1.000 11.92297 ? 325 LEU   B C   1 
ATOM   5357 O O   . LEU   B 1 346 ? 3.55717   9.06723   39.45718  1.000 11.31851 ? 325 LEU   B O   1 
ATOM   5358 C CB  . LEU   B 1 346 ? 5.99721   10.11356  37.45980  1.000 11.99579 ? 325 LEU   B CB  1 
ATOM   5359 C CG  . LEU   B 1 346 ? 6.53995   8.68597   37.43674  1.000 16.52254 ? 325 LEU   B CG  1 
ATOM   5360 C CD1 . LEU   B 1 346 ? 5.78130   7.84032   36.42896  1.000 19.14275 ? 325 LEU   B CD1 1 
ATOM   5361 C CD2 . LEU   B 1 346 ? 8.02681   8.71468   37.11357  1.000 15.11653 ? 325 LEU   B CD2 1 
ATOM   5362 N N   . ALA   B 1 347 ? 4.31396   11.12988  39.94590  1.000 13.32579 ? 326 ALA   B N   1 
ATOM   5363 C CA  . ALA   B 1 347 ? 3.94092   11.01365  41.35296  1.000 12.21116 ? 326 ALA   B CA  1 
ATOM   5364 C C   . ALA   B 1 347 ? 2.42622   10.92910  41.52852  1.000 12.95572 ? 326 ALA   B C   1 
ATOM   5365 O O   . ALA   B 1 347 ? 1.93448   10.16673  42.37015  1.000 14.80421 ? 326 ALA   B O   1 
ATOM   5366 C CB  . ALA   B 1 347 ? 4.51492   12.19116  42.14274  1.000 10.31040 ? 326 ALA   B CB  1 
ATOM   5367 N N   . GLU   B 1 348 ? 1.67206   11.70151  40.74210  1.000 11.11708 ? 327 GLU   B N   1 
ATOM   5368 C CA  . GLU   B 1 348 ? 0.22769   11.79677  40.94270  1.000 10.98508 ? 327 GLU   B CA  1 
ATOM   5369 C C   . GLU   B 1 348 ? -0.50270  10.54091  40.47738  1.000 11.32922 ? 327 GLU   B C   1 
ATOM   5370 O O   . GLU   B 1 348 ? -1.38602  10.03360  41.17946  1.000 7.82123  ? 327 GLU   B O   1 
ATOM   5371 C CB  . GLU   B 1 348 ? -0.31332  13.02912  40.21944  1.000 10.07380 ? 327 GLU   B CB  1 
ATOM   5372 C CG  . GLU   B 1 348 ? 0.25607   14.33836  40.73403  1.000 18.25411 ? 327 GLU   B CG  1 
ATOM   5373 C CD  . GLU   B 1 348 ? -0.08432  15.51624  39.84726  1.000 23.07606 ? 327 GLU   B CD  1 
ATOM   5374 O OE1 . GLU   B 1 348 ? -0.43255  15.29457  38.66766  1.000 16.30235 ? 327 GLU   B OE1 1 
ATOM   5375 O OE2 . GLU   B 1 348 ? -0.00194  16.66507  40.33173  1.000 30.55439 ? 327 GLU   B OE2 1 
ATOM   5376 N N   . VAL   B 1 349 ? -0.16347  10.03038  39.29085  1.000 10.51914 ? 328 VAL   B N   1 
ATOM   5377 C CA  . VAL   B 1 349 ? -0.92651  8.95448   38.66927  1.000 11.11461 ? 328 VAL   B CA  1 
ATOM   5378 C C   . VAL   B 1 349 ? -0.06717  7.77492   38.24434  1.000 9.66526  ? 328 VAL   B C   1 
ATOM   5379 O O   . VAL   B 1 349 ? -0.60995  6.76564   37.79136  1.000 10.74053 ? 328 VAL   B O   1 
ATOM   5380 C CB  . VAL   B 1 349 ? -1.74072  9.46846   37.46354  1.000 10.10152 ? 328 VAL   B CB  1 
ATOM   5381 C CG1 . VAL   B 1 349 ? -2.78820  10.47783  37.91199  1.000 14.77975 ? 328 VAL   B CG1 1 
ATOM   5382 C CG2 . VAL   B 1 349 ? -0.81576  10.06123  36.40485  1.000 13.91093 ? 328 VAL   B CG2 1 
ATOM   5383 N N   . GLY   B 1 350 ? 1.25350   7.85826   38.37474  1.000 10.24752 ? 329 GLY   B N   1 
ATOM   5384 C CA  . GLY   B 1 350 ? 2.09637   6.79780   37.86033  1.000 7.48189  ? 329 GLY   B CA  1 
ATOM   5385 C C   . GLY   B 1 350 ? 2.20162   6.86854   36.34402  1.000 10.23038 ? 329 GLY   B C   1 
ATOM   5386 O O   . GLY   B 1 350 ? 1.81236   7.84391   35.70201  1.000 7.14851  ? 329 GLY   B O   1 
ATOM   5387 N N   . ASN   B 1 351 ? 2.74889   5.79723   35.77364  1.000 10.36372 ? 330 ASN   B N   1 
ATOM   5388 C CA  . ASN   B 1 351 ? 2.87827   5.67154   34.32298  1.000 8.85121  ? 330 ASN   B CA  1 
ATOM   5389 C C   . ASN   B 1 351 ? 1.58475   5.06945   33.78543  1.000 10.09815 ? 330 ASN   B C   1 
ATOM   5390 O O   . ASN   B 1 351 ? 1.34797   3.86574   33.90738  1.000 8.14210  ? 330 ASN   B O   1 
ATOM   5391 C CB  . ASN   B 1 351 ? 4.08711   4.81651   33.95967  1.000 9.31395  ? 330 ASN   B CB  1 
ATOM   5392 C CG  . ASN   B 1 351 ? 4.39638   4.83676   32.47167  1.000 12.71842 ? 330 ASN   B CG  1 
ATOM   5393 O OD1 . ASN   B 1 351 ? 3.50286   4.97878   31.63901  1.000 9.39863  ? 330 ASN   B OD1 1 
ATOM   5394 N ND2 . ASN   B 1 351 ? 5.66761   4.68243   32.13256  1.000 9.03455  ? 330 ASN   B ND2 1 
ATOM   5395 N N   . ILE   B 1 352 ? 0.74873   5.90278   33.16845  1.000 8.82228  ? 331 ILE   B N   1 
ATOM   5396 C CA  . ILE   B 1 352 ? -0.51267  5.42268   32.61229  1.000 8.05992  ? 331 ILE   B CA  1 
ATOM   5397 C C   . ILE   B 1 352 ? -0.36183  5.24067   31.10753  1.000 9.66569  ? 331 ILE   B C   1 
ATOM   5398 O O   . ILE   B 1 352 ? -1.34004  5.32726   30.35391  1.000 6.60984  ? 331 ILE   B O   1 
ATOM   5399 C CB  . ILE   B 1 352 ? -1.68824  6.35272   32.97450  1.000 9.79577  ? 331 ILE   B CB  1 
ATOM   5400 C CG1 . ILE   B 1 352 ? -1.41952  7.79440   32.53437  1.000 8.61353  ? 331 ILE   B CG1 1 
ATOM   5401 C CG2 . ILE   B 1 352 ? -1.97718  6.26795   34.46758  1.000 7.00188  ? 331 ILE   B CG2 1 
ATOM   5402 C CD1 . ILE   B 1 352 ? -2.64550  8.69832   32.60212  1.000 6.89490  ? 331 ILE   B CD1 1 
ATOM   5403 N N   . SER   B 1 353 ? 0.87233   5.00082   30.66834  1.000 8.25440  ? 332 SER   B N   1 
ATOM   5404 C CA  . SER   B 1 353 ? 1.18087   4.54328   29.30485  1.000 8.10622  ? 332 SER   B CA  1 
ATOM   5405 C C   . SER   B 1 353 ? 0.71236   5.60408   28.31087  1.000 5.11332  ? 332 SER   B C   1 
ATOM   5406 O O   . SER   B 1 353 ? 0.98545   6.79597   28.52329  1.000 7.42461  ? 332 SER   B O   1 
ATOM   5407 C CB  . SER   B 1 353 ? 0.57520   3.15545   29.11893  1.000 13.26610 ? 332 SER   B CB  1 
ATOM   5408 O OG  . SER   B 1 353 ? 0.97225   2.57303   27.88929  1.000 13.99206 ? 332 SER   B OG  1 
ATOM   5409 N N   . SER   B 1 354 ? -0.00725  5.23305   27.24943  1.000 5.36619  ? 333 SER   B N   1 
ATOM   5410 C CA  . SER   B 1 354 ? -0.32560  6.17364   26.17990  1.000 6.44108  ? 333 SER   B CA  1 
ATOM   5411 C C   . SER   B 1 354 ? -1.11937  7.37582   26.67692  1.000 6.14831  ? 333 SER   B C   1 
ATOM   5412 O O   . SER   B 1 354 ? -1.03062  8.45825   26.08880  1.000 7.74892  ? 333 SER   B O   1 
ATOM   5413 C CB  . SER   B 1 354 ? -1.09043  5.44968   25.07235  1.000 8.71460  ? 333 SER   B CB  1 
ATOM   5414 O OG  . SER   B 1 354 ? -2.35674  5.01780   25.53540  1.000 10.92687 ? 333 SER   B OG  1 
ATOM   5415 N N   . ALA   B 1 355 ? -1.88544  7.22022   27.75715  1.000 3.85764  ? 334 ALA   B N   1 
ATOM   5416 C CA  . ALA   B 1 355 ? -2.70328  8.32889   28.23232  1.000 8.52062  ? 334 ALA   B CA  1 
ATOM   5417 C C   . ALA   B 1 355 ? -1.89898  9.41263   28.94221  1.000 6.09096  ? 334 ALA   B C   1 
ATOM   5418 O O   . ALA   B 1 355 ? -2.42844  10.51140  29.13784  1.000 6.98523  ? 334 ALA   B O   1 
ATOM   5419 C CB  . ALA   B 1 355 ? -3.80047  7.81042   29.16148  1.000 4.91012  ? 334 ALA   B CB  1 
ATOM   5420 N N   . THR   B 1 356 ? -0.64036  9.14872   29.30795  1.000 5.62476  ? 335 THR   B N   1 
ATOM   5421 C CA  . THR   B 1 356 ? 0.07818   10.05521  30.20393  1.000 8.81983  ? 335 THR   B CA  1 
ATOM   5422 C C   . THR   B 1 356 ? 0.27901   11.43765  29.58127  1.000 6.69221  ? 335 THR   B C   1 
ATOM   5423 O O   . THR   B 1 356 ? -0.00220  12.45697  30.21971  1.000 6.56004  ? 335 THR   B O   1 
ATOM   5424 C CB  . THR   B 1 356 ? 1.42299   9.44683   30.61003  1.000 7.36194  ? 335 THR   B CB  1 
ATOM   5425 O OG1 . THR   B 1 356 ? 1.24924   8.06324   30.93972  1.000 8.14487  ? 335 THR   B OG1 1 
ATOM   5426 C CG2 . THR   B 1 356 ? 1.97826   10.17173  31.82627  1.000 5.21370  ? 335 THR   B CG2 1 
ATOM   5427 N N   . VAL   B 1 357 ? 0.75754   11.50035  28.33366  1.000 8.96748  ? 336 VAL   B N   1 
ATOM   5428 C CA  . VAL   B 1 357 ? 1.00730   12.81253  27.73159  1.000 11.05176 ? 336 VAL   B CA  1 
ATOM   5429 C C   . VAL   B 1 357 ? -0.28645  13.59096  27.52555  1.000 7.88211  ? 336 VAL   B C   1 
ATOM   5430 O O   . VAL   B 1 357 ? -0.26716  14.82676  27.48063  1.000 7.68619  ? 336 VAL   B O   1 
ATOM   5431 C CB  . VAL   B 1 357 ? 1.78631   12.69668  26.40685  1.000 12.10330 ? 336 VAL   B CB  1 
ATOM   5432 C CG1 . VAL   B 1 357 ? 3.16527   12.12322  26.64235  1.000 18.53146 ? 336 VAL   B CG1 1 
ATOM   5433 C CG2 . VAL   B 1 357 ? 1.01835   11.86248  25.40247  1.000 11.76150 ? 336 VAL   B CG2 1 
ATOM   5434 N N   . LEU   B 1 358 ? -1.41765  12.90213  27.35876  1.000 8.70325  ? 337 LEU   B N   1 
ATOM   5435 C CA  . LEU   B 1 358 ? -2.69180  13.61033  27.26680  1.000 6.27825  ? 337 LEU   B CA  1 
ATOM   5436 C C   . LEU   B 1 358 ? -3.09414  14.18203  28.61898  1.000 10.97955 ? 337 LEU   B C   1 
ATOM   5437 O O   . LEU   B 1 358 ? -3.63020  15.29394  28.69693  1.000 11.18616 ? 337 LEU   B O   1 
ATOM   5438 C CB  . LEU   B 1 358 ? -3.77864  12.68273  26.72492  1.000 6.47971  ? 337 LEU   B CB  1 
ATOM   5439 C CG  . LEU   B 1 358 ? -3.52288  12.14814  25.31502  1.000 6.46272  ? 337 LEU   B CG  1 
ATOM   5440 C CD1 . LEU   B 1 358 ? -4.72721  11.38156  24.78372  1.000 10.09654 ? 337 LEU   B CD1 1 
ATOM   5441 C CD2 . LEU   B 1 358 ? -3.15347  13.29056  24.37850  1.000 7.30113  ? 337 LEU   B CD2 1 
ATOM   5442 N N   . TYR   B 1 359 ? -2.84066  13.43103  29.69296  1.000 8.08726  ? 338 TYR   B N   1 
ATOM   5443 C CA  . TYR   B 1 359 ? -3.01867  13.96041  31.03986  1.000 9.14477  ? 338 TYR   B CA  1 
ATOM   5444 C C   . TYR   B 1 359 ? -2.12221  15.17030  31.27145  1.000 9.04229  ? 338 TYR   B C   1 
ATOM   5445 O O   . TYR   B 1 359 ? -2.55439  16.17222  31.85520  1.000 8.37424  ? 338 TYR   B O   1 
ATOM   5446 C CB  . TYR   B 1 359 ? -2.72453  12.85522  32.05649  1.000 7.85663  ? 338 TYR   B CB  1 
ATOM   5447 C CG  . TYR   B 1 359 ? -2.70506  13.27302  33.51381  1.000 7.89317  ? 338 TYR   B CG  1 
ATOM   5448 C CD1 . TYR   B 1 359 ? -1.54596  13.76374  34.10505  1.000 7.86254  ? 338 TYR   B CD1 1 
ATOM   5449 C CD2 . TYR   B 1 359 ? -3.83665  13.13799  34.30853  1.000 8.35492  ? 338 TYR   B CD2 1 
ATOM   5450 C CE1 . TYR   B 1 359 ? -1.52213  14.12827  35.44232  1.000 9.42355  ? 338 TYR   B CE1 1 
ATOM   5451 C CE2 . TYR   B 1 359 ? -3.82286  13.50071  35.64325  1.000 10.63302 ? 338 TYR   B CE2 1 
ATOM   5452 C CZ  . TYR   B 1 359 ? -2.66283  13.99343  36.20472  1.000 12.44249 ? 338 TYR   B CZ  1 
ATOM   5453 O OH  . TYR   B 1 359 ? -2.64579  14.35258  37.53383  1.000 14.44335 ? 338 TYR   B OH  1 
ATOM   5454 N N   . MET   B 1 360 ? -0.86686  15.09340  30.81989  1.000 9.13600  ? 339 MET   B N   1 
ATOM   5455 C CA  . MET   B 1 360 ? 0.05740   16.20813  31.00123  1.000 8.65071  ? 339 MET   B CA  1 
ATOM   5456 C C   . MET   B 1 360 ? -0.37189  17.41230  30.17407  1.000 11.79798 ? 339 MET   B C   1 
ATOM   5457 O O   . MET   B 1 360 ? -0.32844  18.55083  30.65480  1.000 8.88056  ? 339 MET   B O   1 
ATOM   5458 C CB  . MET   B 1 360 ? 1.47391   15.77758  30.62525  1.000 9.58920  ? 339 MET   B CB  1 
ATOM   5459 C CG  . MET   B 1 360 ? 2.00146   14.65896  31.50342  1.000 8.14303  ? 339 MET   B CG  1 
ATOM   5460 S SD  . MET   B 1 360 ? 3.61576   14.03579  31.00673  1.000 10.75972 ? 339 MET   B SD  1 
ATOM   5461 C CE  . MET   B 1 360 ? 4.52642   15.56325  30.79405  1.000 7.31615  ? 339 MET   B CE  1 
ATOM   5462 N N   . LEU   B 1 361 ? -0.79357  17.17954  28.92688  1.000 8.20706  ? 340 LEU   B N   1 
ATOM   5463 C CA  . LEU   B 1 361 ? -1.30096  18.27170  28.10216  1.000 12.56419 ? 340 LEU   B CA  1 
ATOM   5464 C C   . LEU   B 1 361 ? -2.52148  18.91295  28.74713  1.000 8.31130  ? 340 LEU   B C   1 
ATOM   5465 O O   . LEU   B 1 361 ? -2.69591  20.13622  28.68980  1.000 9.12055  ? 340 LEU   B O   1 
ATOM   5466 C CB  . LEU   B 1 361 ? -1.63529  17.75751  26.70085  1.000 10.12082 ? 340 LEU   B CB  1 
ATOM   5467 C CG  . LEU   B 1 361 ? -2.20876  18.76389  25.70032  1.000 14.12937 ? 340 LEU   B CG  1 
ATOM   5468 C CD1 . LEU   B 1 361 ? -1.26471  19.94122  25.50167  1.000 11.99297 ? 340 LEU   B CD1 1 
ATOM   5469 C CD2 . LEU   B 1 361 ? -2.50358  18.08174  24.37271  1.000 15.36191 ? 340 LEU   B CD2 1 
ATOM   5470 N N   . ASP   B 1 362 ? -3.37003  18.10075  29.38040  1.000 9.25463  ? 341 ASP   B N   1 
ATOM   5471 C CA  . ASP   B 1 362 ? -4.51971  18.64487  30.09360  1.000 10.07646 ? 341 ASP   B CA  1 
ATOM   5472 C C   . ASP   B 1 362 ? -4.07770  19.56015  31.22890  1.000 14.41841 ? 341 ASP   B C   1 
ATOM   5473 O O   . ASP   B 1 362 ? -4.68486  20.61343  31.45928  1.000 14.87144 ? 341 ASP   B O   1 
ATOM   5474 C CB  . ASP   B 1 362 ? -5.39393  17.50448  30.61800  1.000 13.46690 ? 341 ASP   B CB  1 
ATOM   5475 C CG  . ASP   B 1 362 ? -6.57426  17.99935  31.42890  1.000 12.92563 ? 341 ASP   B CG  1 
ATOM   5476 O OD1 . ASP   B 1 362 ? -7.61285  18.32841  30.81952  1.000 14.32319 ? 341 ASP   B OD1 1 
ATOM   5477 O OD2 . ASP   B 1 362 ? -6.47060  18.04313  32.67281  1.000 11.56132 ? 341 ASP   B OD2 1 
ATOM   5478 N N   . LYS   B 1 363 ? -3.01410  19.17904  31.94351  1.000 11.61184 ? 342 LYS   B N   1 
ATOM   5479 C CA  . LYS   B 1 363 ? -2.47803  20.04095  32.99219  1.000 13.08893 ? 342 LYS   B CA  1 
ATOM   5480 C C   . LYS   B 1 363 ? -1.97902  21.36108  32.41857  1.000 15.00872 ? 342 LYS   B C   1 
ATOM   5481 O O   . LYS   B 1 363 ? -2.20224  22.42648  33.00666  1.000 17.77725 ? 342 LYS   B O   1 
ATOM   5482 C CB  . LYS   B 1 363 ? -1.34734  19.32761  33.73385  1.000 11.95372 ? 342 LYS   B CB  1 
ATOM   5483 C CG  . LYS   B 1 363 ? -1.79765  18.19980  34.64603  1.000 14.80445 ? 342 LYS   B CG  1 
ATOM   5484 C CD  . LYS   B 1 363 ? -2.57945  18.71603  35.83734  1.000 16.72855 ? 342 LYS   B CD  1 
ATOM   5485 C CE  . LYS   B 1 363 ? -3.14443  17.56727  36.65462  1.000 16.22714 ? 342 LYS   B CE  1 
ATOM   5486 N NZ  . LYS   B 1 363 ? -3.69270  18.04195  37.95454  1.000 24.88440 ? 342 LYS   B NZ  1 
ATOM   5487 N N   . VAL   B 1 364 ? -1.29464  21.30750  31.27206  1.000 14.30923 ? 343 VAL   B N   1 
ATOM   5488 C CA  . VAL   B 1 364 ? -0.73686  22.51576  30.66878  1.000 15.39908 ? 343 VAL   B CA  1 
ATOM   5489 C C   . VAL   B 1 364 ? -1.84690  23.48097  30.28084  1.000 19.97495 ? 343 VAL   B C   1 
ATOM   5490 O O   . VAL   B 1 364 ? -1.75411  24.69089  30.52535  1.000 22.92653 ? 343 VAL   B O   1 
ATOM   5491 C CB  . VAL   B 1 364 ? 0.14328   22.15182  29.45785  1.000 13.80094 ? 343 VAL   B CB  1 
ATOM   5492 C CG1 . VAL   B 1 364 ? 0.41845   23.38612  28.60688  1.000 20.31085 ? 343 VAL   B CG1 1 
ATOM   5493 C CG2 . VAL   B 1 364 ? 1.44741   21.51739  29.91917  1.000 18.26497 ? 343 VAL   B CG2 1 
ATOM   5494 N N   . LEU   B 1 365 ? -2.91994  22.96227  29.68336  1.000 18.10554 ? 344 LEU   B N   1 
ATOM   5495 C CA  . LEU   B 1 365 ? -4.01562  23.81015  29.23352  1.000 18.95372 ? 344 LEU   B CA  1 
ATOM   5496 C C   . LEU   B 1 365 ? -4.76968  24.45841  30.38736  1.000 23.10573 ? 344 LEU   B C   1 
ATOM   5497 O O   . LEU   B 1 365 ? -5.57022  25.36829  30.14797  1.000 23.83979 ? 344 LEU   B O   1 
ATOM   5498 C CB  . LEU   B 1 365 ? -4.96887  22.99434  28.35978  1.000 16.68614 ? 344 LEU   B CB  1 
ATOM   5499 C CG  . LEU   B 1 365 ? -4.34121  22.54227  27.03627  1.000 18.44742 ? 344 LEU   B CG  1 
ATOM   5500 C CD1 . LEU   B 1 365 ? -5.36466  21.87156  26.13227  1.000 19.36166 ? 344 LEU   B CD1 1 
ATOM   5501 C CD2 . LEU   B 1 365 ? -3.67947  23.71737  26.32404  1.000 24.25017 ? 344 LEU   B CD2 1 
ATOM   5502 N N   . SER   B 1 366 ? -4.53775  24.01811  31.62206  1.000 29.19261 ? 345 SER   B N   1 
ATOM   5503 C CA  . SER   B 1 366 ? -5.07624  24.68021  32.80111  1.000 24.25707 ? 345 SER   B CA  1 
ATOM   5504 C C   . SER   B 1 366 ? -4.05921  25.58759  33.48231  1.000 33.16875 ? 345 SER   B C   1 
ATOM   5505 O O   . SER   B 1 366 ? -4.41363  26.28613  34.43733  1.000 34.20022 ? 345 SER   B O   1 
ATOM   5506 C CB  . SER   B 1 366 ? -5.60305  23.64025  33.79389  1.000 27.44850 ? 345 SER   B CB  1 
ATOM   5507 O OG  . SER   B 1 366 ? -6.55162  22.79028  33.17022  1.000 43.53310 ? 345 SER   B OG  1 
ATOM   5508 N N   . GLU   B 1 367 ? -2.81155  25.59696  33.01634  1.000 26.76642 ? 346 GLU   B N   1 
ATOM   5509 C CA  . GLU   B 1 367 ? -1.84868  26.59223  33.45949  1.000 29.92038 ? 346 GLU   B CA  1 
ATOM   5510 C C   . GLU   B 1 367 ? -2.21849  27.94627  32.85528  1.000 35.60547 ? 346 GLU   B C   1 
ATOM   5511 O O   . GLU   B 1 367 ? -3.16469  28.06785  32.07079  1.000 29.04164 ? 346 GLU   B O   1 
ATOM   5512 C CB  . GLU   B 1 367 ? -0.43123  26.17557  33.06782  1.000 28.58224 ? 346 GLU   B CB  1 
ATOM   5513 C CG  . GLU   B 1 367 ? 0.15638   25.07397  33.93875  1.000 28.18955 ? 346 GLU   B CG  1 
ATOM   5514 C CD  . GLU   B 1 367 ? 1.51497   24.59060  33.45346  1.000 31.62243 ? 346 GLU   B CD  1 
ATOM   5515 O OE1 . GLU   B 1 367 ? 1.94090   24.99198  32.34892  1.000 35.61921 ? 346 GLU   B OE1 1 
ATOM   5516 O OE2 . GLU   B 1 367 ? 2.15547   23.80034  34.18039  1.000 43.38822 ? 346 GLU   B OE2 1 
ATOM   5517 N N   . GLU   B 1 368 ? -1.47036  28.98537  33.21912  1.000 37.66864 ? 347 GLU   B N   1 
ATOM   5518 C CA  . GLU   B 1 368 ? -1.78332  30.29856  32.67824  1.000 42.53217 ? 347 GLU   B CA  1 
ATOM   5519 C C   . GLU   B 1 368 ? -1.51120  30.33055  31.17775  1.000 38.26372 ? 347 GLU   B C   1 
ATOM   5520 O O   . GLU   B 1 368 ? -0.74627  29.52421  30.63800  1.000 36.06463 ? 347 GLU   B O   1 
ATOM   5521 C CB  . GLU   B 1 368 ? -0.98162  31.40095  33.37243  1.000 43.26379 ? 347 GLU   B CB  1 
ATOM   5522 C CG  . GLU   B 1 368 ? 0.52336   31.32452  33.18409  1.000 39.85514 ? 347 GLU   B CG  1 
ATOM   5523 C CD  . GLU   B 1 368 ? 1.25424   32.38987  33.98079  1.000 54.73013 ? 347 GLU   B CD  1 
ATOM   5524 O OE1 . GLU   B 1 368 ? 0.60036   33.36996  34.39684  1.000 52.93545 ? 347 GLU   B OE1 1 
ATOM   5525 O OE2 . GLU   B 1 368 ? 2.47967   32.25558  34.18323  1.000 56.78811 ? 347 GLU   B OE2 1 
ATOM   5526 N N   . GLN   B 1 369 ? -2.17305  31.27068  30.50579  1.000 32.97008 ? 348 GLN   B N   1 
ATOM   5527 C CA  . GLN   B 1 369 ? -2.04605  31.42566  29.06303  1.000 31.57495 ? 348 GLN   B CA  1 
ATOM   5528 C C   . GLN   B 1 369 ? -0.58487  31.49319  28.65512  1.000 34.55395 ? 348 GLN   B C   1 
ATOM   5529 O O   . GLN   B 1 369 ? 0.15241   32.38135  29.09281  1.000 38.74068 ? 348 GLN   B O   1 
ATOM   5530 C CB  . GLN   B 1 369 ? -2.78307  32.68750  28.60967  1.000 31.43961 ? 348 GLN   B CB  1 
ATOM   5531 C CG  . GLN   B 1 369 ? -2.63793  33.00077  27.12718  1.000 33.60054 ? 348 GLN   B CG  1 
ATOM   5532 C CD  . GLN   B 1 369 ? -3.10290  31.86561  26.23132  1.000 29.43935 ? 348 GLN   B CD  1 
ATOM   5533 O OE1 . GLN   B 1 369 ? -4.21846  31.36396  26.37174  1.000 27.32750 ? 348 GLN   B OE1 1 
ATOM   5534 N NE2 . GLN   B 1 369 ? -2.25016  31.46415  25.29489  1.000 25.61584 ? 348 GLN   B NE2 1 
ATOM   5535 N N   . SER   B 1 370 ? -0.17056  30.53802  27.83075  1.000 31.22970 ? 349 SER   B N   1 
ATOM   5536 C CA  . SER   B 1 370 ? 1.19756   30.52528  27.34409  1.000 33.26255 ? 349 SER   B CA  1 
ATOM   5537 C C   . SER   B 1 370 ? 1.47258   31.80725  26.56342  1.000 35.12147 ? 349 SER   B C   1 
ATOM   5538 O O   . SER   B 1 370 ? 0.59133   32.29630  25.84433  1.000 30.97628 ? 349 SER   B O   1 
ATOM   5539 C CB  . SER   B 1 370 ? 1.44178   29.30460  26.45457  1.000 24.76381 ? 349 SER   B CB  1 
ATOM   5540 O OG  . SER   B 1 370 ? 1.33556   28.10210  27.19688  1.000 28.63222 ? 349 SER   B OG  1 
ATOM   5541 N N   . PRO   B 1 371 ? 2.65847   32.39234  26.70495  1.000 37.62570 ? 350 PRO   B N   1 
ATOM   5542 C CA  . PRO   B 1 371 ? 2.99467   33.58353  25.92845  1.000 39.87273 ? 350 PRO   B CA  1 
ATOM   5543 C C   . PRO   B 1 371 ? 2.82268   33.31791  24.44547  1.000 39.69501 ? 350 PRO   B C   1 
ATOM   5544 O O   . PRO   B 1 371 ? 3.13621   32.22173  23.95808  1.000 40.04850 ? 350 PRO   B O   1 
ATOM   5545 C CB  . PRO   B 1 371 ? 4.46688   33.83923  26.28268  1.000 35.51540 ? 350 PRO   B CB  1 
ATOM   5546 C CG  . PRO   B 1 371 ? 4.65748   33.21738  27.61945  1.000 42.58770 ? 350 PRO   B CG  1 
ATOM   5547 C CD  . PRO   B 1 371 ? 3.62840   32.12666  27.78110  1.000 37.02470 ? 350 PRO   B CD  1 
ATOM   5548 N N   . PRO   B 1 372 ? 2.29110   34.28406  23.70542  1.000 36.88792 ? 351 PRO   B N   1 
ATOM   5549 C CA  . PRO   B 1 372 ? 2.07479   34.08089  22.26864  1.000 36.40456 ? 351 PRO   B CA  1 
ATOM   5550 C C   . PRO   B 1 372 ? 3.38717   33.83395  21.54362  1.000 39.71322 ? 351 PRO   B C   1 
ATOM   5551 O O   . PRO   B 1 372 ? 4.44379   34.33388  21.93628  1.000 40.98771 ? 351 PRO   B O   1 
ATOM   5552 C CB  . PRO   B 1 372 ? 1.41741   35.38704  21.80579  1.000 41.82074 ? 351 PRO   B CB  1 
ATOM   5553 C CG  . PRO   B 1 372 ? 1.35498   36.27298  22.98590  1.000 33.42682 ? 351 PRO   B CG  1 
ATOM   5554 C CD  . PRO   B 1 372 ? 1.81881   35.58542  24.19905  1.000 43.98316 ? 351 PRO   B CD  1 
ATOM   5555 N N   . ASP   B 1 373 ? 3.30545   33.03062  20.48311  1.000 33.82769 ? 352 ASP   B N   1 
ATOM   5556 C CA  . ASP   B 1 373 ? 4.42857   32.61605  19.64714  1.000 33.51077 ? 352 ASP   B CA  1 
ATOM   5557 C C   . ASP   B 1 373 ? 5.44156   31.75659  20.39225  1.000 29.19873 ? 352 ASP   B C   1 
ATOM   5558 O O   . ASP   B 1 373 ? 6.49404   31.43187  19.83012  1.000 32.65173 ? 352 ASP   B O   1 
ATOM   5559 C CB  . ASP   B 1 373 ? 5.14344   33.81657  19.01478  1.000 35.28618 ? 352 ASP   B CB  1 
ATOM   5560 C CG  . ASP   B 1 373 ? 4.33683   34.45082  17.89857  1.000 52.97230 ? 352 ASP   B CG  1 
ATOM   5561 O OD1 . ASP   B 1 373 ? 4.86518   35.35350  17.21808  1.000 55.50954 ? 352 ASP   B OD1 1 
ATOM   5562 O OD2 . ASP   B 1 373 ? 3.17058   34.04386  17.70163  1.000 55.37961 ? 352 ASP   B OD2 1 
ATOM   5563 N N   . SER   B 1 374 ? 5.16092   31.37599  21.63579  1.000 26.57194 ? 353 SER   B N   1 
ATOM   5564 C CA  . SER   B 1 374 ? 6.05006   30.47733  22.35513  1.000 21.42114 ? 353 SER   B CA  1 
ATOM   5565 C C   . SER   B 1 374 ? 5.91298   29.05671  21.81728  1.000 26.57672 ? 353 SER   B C   1 
ATOM   5566 O O   . SER   B 1 374 ? 4.83717   28.62805  21.39037  1.000 26.61915 ? 353 SER   B O   1 
ATOM   5567 C CB  . SER   B 1 374 ? 5.75424   30.51280  23.85438  1.000 28.35343 ? 353 SER   B CB  1 
ATOM   5568 O OG  . SER   B 1 374 ? 4.51533   29.89440  24.15332  1.000 31.24779 ? 353 SER   B OG  1 
ATOM   5569 N N   . TYR   B 1 375 ? 7.02172   28.32440  21.83794  1.000 19.33248 ? 354 TYR   B N   1 
ATOM   5570 C CA  . TYR   B 1 375 ? 7.10237   27.00863  21.22286  1.000 23.89801 ? 354 TYR   B CA  1 
ATOM   5571 C C   . TYR   B 1 375 ? 7.13467   25.92181  22.28770  1.000 20.64681 ? 354 TYR   B C   1 
ATOM   5572 O O   . TYR   B 1 375 ? 7.72981   26.09985  23.35519  1.000 19.63428 ? 354 TYR   B O   1 
ATOM   5573 C CB  . TYR   B 1 375 ? 8.33984   26.90411  20.33153  1.000 21.21725 ? 354 TYR   B CB  1 
ATOM   5574 C CG  . TYR   B 1 375 ? 8.20326   27.66243  19.03528  1.000 24.91445 ? 354 TYR   B CG  1 
ATOM   5575 C CD1 . TYR   B 1 375 ? 7.64822   27.06166  17.91452  1.000 23.56903 ? 354 TYR   B CD1 1 
ATOM   5576 C CD2 . TYR   B 1 375 ? 8.61890   28.98358  18.93336  1.000 28.40781 ? 354 TYR   B CD2 1 
ATOM   5577 C CE1 . TYR   B 1 375 ? 7.51663   27.75219  16.72591  1.000 31.00953 ? 354 TYR   B CE1 1 
ATOM   5578 C CE2 . TYR   B 1 375 ? 8.48975   29.68310  17.74831  1.000 26.66581 ? 354 TYR   B CE2 1 
ATOM   5579 C CZ  . TYR   B 1 375 ? 7.93830   29.06153  16.64731  1.000 28.36654 ? 354 TYR   B CZ  1 
ATOM   5580 O OH  . TYR   B 1 375 ? 7.80699   29.74848  15.46182  1.000 39.74342 ? 354 TYR   B OH  1 
ATOM   5581 N N   . GLY   B 1 376 ? 6.48933   24.79410  21.98604  1.000 21.36984 ? 355 GLY   B N   1 
ATOM   5582 C CA  . GLY   B 1 376 ? 6.46712   23.66844  22.88933  1.000 17.42453 ? 355 GLY   B CA  1 
ATOM   5583 C C   . GLY   B 1 376 ? 6.78126   22.37878  22.15596  1.000 12.60349 ? 355 GLY   B C   1 
ATOM   5584 O O   . GLY   B 1 376 ? 6.65401   22.28075  20.93550  1.000 12.96673 ? 355 GLY   B O   1 
ATOM   5585 N N   . LEU   B 1 377 ? 7.19902   21.38111  22.93283  1.000 14.32783 ? 356 LEU   B N   1 
ATOM   5586 C CA  . LEU   B 1 377 ? 7.56049   20.07269  22.40430  1.000 9.95465  ? 356 LEU   B CA  1 
ATOM   5587 C C   . LEU   B 1 377 ? 6.88527   18.98068  23.21917  1.000 13.01756 ? 356 LEU   B C   1 
ATOM   5588 O O   . LEU   B 1 377 ? 7.01559   18.94923  24.44763  1.000 13.63805 ? 356 LEU   B O   1 
ATOM   5589 C CB  . LEU   B 1 377 ? 9.07784   19.86910  22.43222  1.000 12.44901 ? 356 LEU   B CB  1 
ATOM   5590 C CG  . LEU   B 1 377 ? 9.68594   18.95582  21.37218  1.000 12.91904 ? 356 LEU   B CG  1 
ATOM   5591 C CD1 . LEU   B 1 377 ? 9.25399   19.39160  19.98309  1.000 13.73720 ? 356 LEU   B CD1 1 
ATOM   5592 C CD2 . LEU   B 1 377 ? 11.19813  18.94610  21.50386  1.000 16.80298 ? 356 LEU   B CD2 1 
ATOM   5593 N N   . ILE   B 1 378 ? 6.17741   18.08322  22.53593  1.000 10.22925 ? 357 ILE   B N   1 
ATOM   5594 C CA  . ILE   B 1 378 ? 5.69666   16.83860  23.12772  1.000 14.59733 ? 357 ILE   B CA  1 
ATOM   5595 C C   . ILE   B 1 378 ? 6.64151   15.72515  22.69948  1.000 8.25468  ? 357 ILE   B C   1 
ATOM   5596 O O   . ILE   B 1 378 ? 6.93399   15.57716  21.50690  1.000 10.84472 ? 357 ILE   B O   1 
ATOM   5597 C CB  . ILE   B 1 378 ? 4.25139   16.52590  22.70229  1.000 7.43159  ? 357 ILE   B CB  1 
ATOM   5598 C CG1 . ILE   B 1 378 ? 3.29347   17.63153  23.15128  1.000 7.35839  ? 357 ILE   B CG1 1 
ATOM   5599 C CG2 . ILE   B 1 378 ? 3.81280   15.17574  23.25345  1.000 7.83241  ? 357 ILE   B CG2 1 
ATOM   5600 C CD1 . ILE   B 1 378 ? 1.90239   17.50411  22.54368  1.000 13.43769 ? 357 ILE   B CD1 1 
ATOM   5601 N N   . VAL   B 1 379 ? 7.14066   14.95817  23.66626  1.000 5.60019  ? 358 VAL   B N   1 
ATOM   5602 C CA  . VAL   B 1 379 ? 8.08660   13.87892  23.40318  1.000 10.05418 ? 358 VAL   B CA  1 
ATOM   5603 C C   . VAL   B 1 379 ? 7.59272   12.61533  24.09331  1.000 9.61191  ? 358 VAL   B C   1 
ATOM   5604 O O   . VAL   B 1 379 ? 7.30310   12.63457  25.29412  1.000 11.49331 ? 358 VAL   B O   1 
ATOM   5605 C CB  . VAL   B 1 379 ? 9.50598   14.23379  23.88865  1.000 8.39559  ? 358 VAL   B CB  1 
ATOM   5606 C CG1 . VAL   B 1 379 ? 10.44892  13.05437  23.69535  1.000 8.38654  ? 358 VAL   B CG1 1 
ATOM   5607 C CG2 . VAL   B 1 379 ? 10.02392  15.46255  23.16441  1.000 11.41122 ? 358 VAL   B CG2 1 
ATOM   5608 N N   . ALA   B 1 380 ? 7.51383   11.51598  23.34339  1.000 8.44887  ? 359 ALA   B N   1 
ATOM   5609 C CA  . ALA   B 1 380 ? 7.11129   10.23414  23.90397  1.000 10.18654 ? 359 ALA   B CA  1 
ATOM   5610 C C   . ALA   B 1 380 ? 8.02059   9.13906   23.36873  1.000 11.60137 ? 359 ALA   B C   1 
ATOM   5611 O O   . ALA   B 1 380 ? 8.62642   9.26774   22.30247  1.000 14.04621 ? 359 ALA   B O   1 
ATOM   5612 C CB  . ALA   B 1 380 ? 5.64577   9.90232   23.59287  1.000 12.39713 ? 359 ALA   B CB  1 
ATOM   5613 N N   . MET   B 1 381 ? 8.11934   8.05906   24.13776  1.000 10.81957 ? 360 MET   B N   1 
ATOM   5614 C CA  . MET   B 1 381 ? 8.93053   6.91000   23.77038  1.000 14.98433 ? 360 MET   B CA  1 
ATOM   5615 C C   . MET   B 1 381 ? 8.13244   5.64269   24.03672  1.000 11.15159 ? 360 MET   B C   1 
ATOM   5616 O O   . MET   B 1 381 ? 7.35386   5.57690   24.99106  1.000 12.90477 ? 360 MET   B O   1 
ATOM   5617 C CB  . MET   B 1 381 ? 10.26134  6.89199   24.54306  1.000 10.29342 ? 360 MET   B CB  1 
ATOM   5618 C CG  . MET   B 1 381 ? 10.15241  7.04784   26.06480  1.000 22.97381 ? 360 MET   B CG  1 
ATOM   5619 S SD  . MET   B 1 381 ? 9.24379   8.50478   26.63193  1.000 24.35424 ? 360 MET   B SD  1 
ATOM   5620 C CE  . MET   B 1 381 ? 10.52187  9.76102   26.60908  1.000 23.72296 ? 360 MET   B CE  1 
ATOM   5621 N N   . GLY   B 1 382 ? 8.32407   4.63702   23.18392  1.000 9.55534  ? 361 GLY   B N   1 
ATOM   5622 C CA  . GLY   B 1 382 ? 7.58467   3.40265   23.31180  1.000 9.01565  ? 361 GLY   B CA  1 
ATOM   5623 C C   . GLY   B 1 382 ? 8.17560   2.23948   22.53861  1.000 13.01273 ? 361 GLY   B C   1 
ATOM   5624 O O   . GLY   B 1 382 ? 9.27805   2.31936   21.98736  1.000 10.02847 ? 361 GLY   B O   1 
ATOM   5625 N N   . PRO   B 1 383 ? 7.43122   1.12078   22.48858  1.000 13.14375 ? 362 PRO   B N   1 
ATOM   5626 C CA  . PRO   B 1 383 ? 7.88759   -0.06490  21.74431  1.000 11.29652 ? 362 PRO   B CA  1 
ATOM   5627 C C   . PRO   B 1 383 ? 8.27171   0.25974   20.31309  1.000 10.48529 ? 362 PRO   B C   1 
ATOM   5628 O O   . PRO   B 1 383 ? 7.73863   1.21127   19.73339  1.000 8.05424  ? 362 PRO   B O   1 
ATOM   5629 C CB  . PRO   B 1 383 ? 6.67008   -0.99513  21.79997  1.000 10.60267 ? 362 PRO   B CB  1 
ATOM   5630 C CG  . PRO   B 1 383 ? 5.98022   -0.59837  23.06515  1.000 9.62266  ? 362 PRO   B CG  1 
ATOM   5631 C CD  . PRO   B 1 383 ? 6.12139   0.89753   23.12209  1.000 12.93883 ? 362 PRO   B CD  1 
ATOM   5632 N N   . GLY   B 1 384 ? 9.11538   -0.56574  19.69675  1.000 12.25866 ? 363 GLY   B N   1 
ATOM   5633 C CA  . GLY   B 1 384 ? 9.93978   -0.04414  18.62815  1.000 9.54239  ? 363 GLY   B CA  1 
ATOM   5634 C C   . GLY   B 1 384 ? 11.34389  -0.61184  18.57572  1.000 12.45976 ? 363 GLY   B C   1 
ATOM   5635 O O   . GLY   B 1 384 ? 11.54975  -1.72610  18.08884  1.000 13.19869 ? 363 GLY   B O   1 
ATOM   5636 N N   . LEU   B 1 385 ? 12.32439  0.16348   19.01648  1.000 10.33753 ? 364 LEU   B N   1 
ATOM   5637 C CA  . LEU   B 1 385 ? 12.07119  1.22358   19.98051  1.000 9.76913  ? 364 LEU   B CA  1 
ATOM   5638 C C   . LEU   B 1 385 ? 11.82769  2.55164   19.27786  1.000 8.31981  ? 364 LEU   B C   1 
ATOM   5639 O O   . LEU   B 1 385 ? 12.67521  3.02398   18.52770  1.000 15.51837 ? 364 LEU   B O   1 
ATOM   5640 C CB  . LEU   B 1 385 ? 13.25043  1.32205   20.94527  1.000 12.41212 ? 364 LEU   B CB  1 
ATOM   5641 C CG  . LEU   B 1 385 ? 13.02972  2.00504   22.28283  1.000 16.43970 ? 364 LEU   B CG  1 
ATOM   5642 C CD1 . LEU   B 1 385 ? 12.35316  1.02444   23.21659  1.000 24.51503 ? 364 LEU   B CD1 1 
ATOM   5643 C CD2 . LEU   B 1 385 ? 14.34964  2.47790   22.86280  1.000 21.98164 ? 364 LEU   B CD2 1 
ATOM   5644 N N   . ALA   B 1 386 ? 10.66026  3.14316   19.52055  1.000 8.02549  ? 365 ALA   B N   1 
ATOM   5645 C CA  . ALA   B 1 386 ? 10.18533  4.27892   18.74788  1.000 7.80701  ? 365 ALA   B CA  1 
ATOM   5646 C C   . ALA   B 1 386 ? 10.02673  5.51358   19.62457  1.000 11.92065 ? 365 ALA   B C   1 
ATOM   5647 O O   . ALA   B 1 386 ? 9.69916   5.42054   20.81088  1.000 8.58287  ? 365 ALA   B O   1 
ATOM   5648 C CB  . ALA   B 1 386 ? 8.84821   3.96139   18.06315  1.000 13.52807 ? 365 ALA   B CB  1 
ATOM   5649 N N   . GLN   B 1 387 ? 10.25873  6.67748   19.01846  1.000 10.19503 ? 366 GLN   B N   1 
ATOM   5650 C CA  . GLN   B 1 387 ? 10.09377  7.96335   19.68015  1.000 8.71652  ? 366 GLN   B CA  1 
ATOM   5651 C C   . GLN   B 1 387 ? 9.27708   8.88440   18.78586  1.000 11.01816 ? 366 GLN   B C   1 
ATOM   5652 O O   . GLN   B 1 387 ? 9.36098   8.81598   17.55648  1.000 11.94057 ? 366 GLN   B O   1 
ATOM   5653 C CB  . GLN   B 1 387 ? 11.44907  8.61682   20.01723  1.000 10.77022 ? 366 GLN   B CB  1 
ATOM   5654 C CG  . GLN   B 1 387 ? 12.39386  7.74145   20.82768  1.000 10.30471 ? 366 GLN   B CG  1 
ATOM   5655 C CD  . GLN   B 1 387 ? 13.09665  6.68641   19.99631  1.000 19.84837 ? 366 GLN   B CD  1 
ATOM   5656 O OE1 . GLN   B 1 387 ? 13.59331  6.96581   18.90274  1.000 14.27623 ? 366 GLN   B OE1 1 
ATOM   5657 N NE2 . GLN   B 1 387 ? 13.12536  5.45807   20.50430  1.000 21.58513 ? 366 GLN   B NE2 1 
ATOM   5658 N N   . GLU   B 1 388 ? 8.47711   9.74154   19.41483  1.000 8.22817  ? 367 GLU   B N   1 
ATOM   5659 C CA  . GLU   B 1 388 ? 7.59971   10.65359  18.69897  1.000 6.98562  ? 367 GLU   B CA  1 
ATOM   5660 C C   . GLU   B 1 388 ? 7.81257   12.06582  19.22437  1.000 8.82072  ? 367 GLU   B C   1 
ATOM   5661 O O   . GLU   B 1 388 ? 7.93284   12.27540  20.43559  1.000 8.32054  ? 367 GLU   B O   1 
ATOM   5662 C CB  . GLU   B 1 388 ? 6.13069   10.23484  18.84862  1.000 6.21806  ? 367 GLU   B CB  1 
ATOM   5663 C CG  . GLU   B 1 388 ? 5.17673   10.95364  17.90040  1.000 8.08041  ? 367 GLU   B CG  1 
ATOM   5664 C CD  . GLU   B 1 388 ? 5.24352   10.40982  16.48139  1.000 11.91278 ? 367 GLU   B CD  1 
ATOM   5665 O OE1 . GLU   B 1 388 ? 5.95969   9.41223   16.25183  1.000 14.19271 ? 367 GLU   B OE1 1 
ATOM   5666 O OE2 . GLU   B 1 388 ? 4.58019   10.98365  15.59247  1.000 12.37079 ? 367 GLU   B OE2 1 
ATOM   5667 N N   . ALA   B 1 389 ? 7.88228   13.03111  18.31073  1.000 7.77861  ? 368 ALA   B N   1 
ATOM   5668 C CA  . ALA   B 1 389 ? 8.10048   14.42410  18.67569  1.000 8.80794  ? 368 ALA   B CA  1 
ATOM   5669 C C   . ALA   B 1 389 ? 7.09861   15.30061  17.94452  1.000 8.06953  ? 368 ALA   B C   1 
ATOM   5670 O O   . ALA   B 1 389 ? 6.91675   15.16194  16.73159  1.000 10.75259 ? 368 ALA   B O   1 
ATOM   5671 C CB  . ALA   B 1 389 ? 9.53139   14.86934  18.35446  1.000 8.62905  ? 368 ALA   B CB  1 
ATOM   5672 N N   . ILE   B 1 390 ? 6.45292   16.19900  18.68366  1.000 6.60834  ? 369 ILE   B N   1 
ATOM   5673 C CA  . ILE   B 1 390 ? 5.45851   17.11192  18.13444  1.000 7.74699  ? 369 ILE   B CA  1 
ATOM   5674 C C   . ILE   B 1 390 ? 5.85273   18.53019  18.50960  1.000 8.90272  ? 369 ILE   B C   1 
ATOM   5675 O O   . ILE   B 1 390 ? 6.06210   18.82660  19.69064  1.000 11.99469 ? 369 ILE   B O   1 
ATOM   5676 C CB  . ILE   B 1 390 ? 4.04107   16.80351  18.65209  1.000 7.43872  ? 369 ILE   B CB  1 
ATOM   5677 C CG1 . ILE   B 1 390 ? 3.69161   15.33415  18.42458  1.000 7.17435  ? 369 ILE   B CG1 1 
ATOM   5678 C CG2 . ILE   B 1 390 ? 3.02308   17.70496  17.97494  1.000 10.25584 ? 369 ILE   B CG2 1 
ATOM   5679 C CD1 . ILE   B 1 390 ? 2.68952   14.79314  19.42484  1.000 9.16063  ? 369 ILE   B CD1 1 
ATOM   5680 N N   . LEU   B 1 391 ? 5.93863   19.40474  17.51265  1.000 11.02773 ? 370 LEU   B N   1 
ATOM   5681 C CA  . LEU   B 1 391 ? 6.26799   20.80715  17.72551  1.000 13.79313 ? 370 LEU   B CA  1 
ATOM   5682 C C   . LEU   B 1 391 ? 4.97627   21.61007  17.83046  1.000 15.15508 ? 370 LEU   B C   1 
ATOM   5683 O O   . LEU   B 1 391 ? 4.14694   21.58134  16.91465  1.000 12.91544 ? 370 LEU   B O   1 
ATOM   5684 C CB  . LEU   B 1 391 ? 7.14160   21.33730  16.59019  1.000 13.41582 ? 370 LEU   B CB  1 
ATOM   5685 C CG  . LEU   B 1 391 ? 7.63380   22.78005  16.73084  1.000 12.96340 ? 370 LEU   B CG  1 
ATOM   5686 C CD1 . LEU   B 1 391 ? 8.45013   22.96943  18.00567  1.000 12.28699 ? 370 LEU   B CD1 1 
ATOM   5687 C CD2 . LEU   B 1 391 ? 8.42442   23.19641  15.49923  1.000 12.38568 ? 370 LEU   B CD2 1 
ATOM   5688 N N   . LEU   B 1 392 ? 4.81276   22.32424  18.94097  1.000 13.48609 ? 371 LEU   B N   1 
ATOM   5689 C CA  . LEU   B 1 392 ? 3.63954   23.14394  19.20198  1.000 14.42390 ? 371 LEU   B CA  1 
ATOM   5690 C C   . LEU   B 1 392 ? 4.01248   24.61972  19.19142  1.000 20.69039 ? 371 LEU   B C   1 
ATOM   5691 O O   . LEU   B 1 392 ? 5.15036   24.99240  19.49011  1.000 16.21452 ? 371 LEU   B O   1 
ATOM   5692 C CB  . LEU   B 1 392 ? 3.00989   22.79804  20.55534  1.000 11.64986 ? 371 LEU   B CB  1 
ATOM   5693 C CG  . LEU   B 1 392 ? 2.65395   21.33495  20.79420  1.000 11.51126 ? 371 LEU   B CG  1 
ATOM   5694 C CD1 . LEU   B 1 392 ? 2.08814   21.16092  22.18872  1.000 13.25971 ? 371 LEU   B CD1 1 
ATOM   5695 C CD2 . LEU   B 1 392 ? 1.65933   20.87529  19.74551  1.000 12.29492 ? 371 LEU   B CD2 1 
ATOM   5696 N N   . LYS   B 1 393 ? 3.03668   25.45977  18.85437  1.000 17.66115 ? 372 LYS   B N   1 
ATOM   5697 C CA  . LYS   B 1 393 ? 3.21856   26.90422  18.88848  1.000 21.55518 ? 372 LYS   B CA  1 
ATOM   5698 C C   . LYS   B 1 393 ? 1.93523   27.55017  19.38523  1.000 24.05078 ? 372 LYS   B C   1 
ATOM   5699 O O   . LYS   B 1 393 ? 0.85728   27.28263  18.84711  1.000 20.63281 ? 372 LYS   B O   1 
ATOM   5700 C CB  . LYS   B 1 393 ? 3.59402   27.44907  17.50524  1.000 21.24596 ? 372 LYS   B CB  1 
ATOM   5701 C CG  . LYS   B 1 393 ? 4.20764   28.84263  17.52602  1.000 31.20985 ? 372 LYS   B CG  1 
ATOM   5702 C CD  . LYS   B 1 393 ? 4.15014   29.49586  16.15270  1.000 27.63787 ? 372 LYS   B CD  1 
ATOM   5703 C CE  . LYS   B 1 393 ? 2.71530   29.73604  15.70633  1.000 42.01721 ? 372 LYS   B CE  1 
ATOM   5704 N NZ  . LYS   B 1 393 ? 1.87103   30.27006  16.81298  1.000 36.20650 ? 372 LYS   B NZ  1 
ATOM   5705 N N   . TRP   B 1 394 ? 2.05437   28.39328  20.40749  1.000 19.46906 ? 373 TRP   B N   1 
ATOM   5706 C CA  . TRP   B 1 394 ? 0.90588   29.10397  20.96188  1.000 19.69663 ? 373 TRP   B CA  1 
ATOM   5707 C C   . TRP   B 1 394 ? 0.74152   30.47648  20.31655  1.000 26.02231 ? 373 TRP   B C   1 
ATOM   5708 O O   . TRP   B 1 394 ? 1.46493   30.82257  19.38244  1.000 28.39089 ? 373 TRP   B O   1 
ATOM   5709 C CB  . TRP   B 1 394 ? 1.04623   29.25462  22.47798  1.000 21.50218 ? 373 TRP   B CB  1 
ATOM   5710 C CG  . TRP   B 1 394 ? 0.60014   28.05033  23.24522  1.000 22.32946 ? 373 TRP   B CG  1 
ATOM   5711 C CD1 . TRP   B 1 394 ? -0.63172  27.83653  23.78896  1.000 22.16441 ? 373 TRP   B CD1 1 
ATOM   5712 C CD2 . TRP   B 1 394 ? 1.38360   26.89358  23.55945  1.000 18.17467 ? 373 TRP   B CD2 1 
ATOM   5713 N NE1 . TRP   B 1 394 ? -0.66557  26.61765  24.42062  1.000 25.78886 ? 373 TRP   B NE1 1 
ATOM   5714 C CE2 . TRP   B 1 394 ? 0.56091   26.02024  24.29632  1.000 19.70536 ? 373 TRP   B CE2 1 
ATOM   5715 C CE3 . TRP   B 1 394 ? 2.70167   26.51290  23.29150  1.000 19.64650 ? 373 TRP   B CE3 1 
ATOM   5716 C CZ2 . TRP   B 1 394 ? 1.01040   24.78653  24.76311  1.000 21.09470 ? 373 TRP   B CZ2 1 
ATOM   5717 C CZ3 . TRP   B 1 394 ? 3.14708   25.28892  23.75849  1.000 17.73329 ? 373 TRP   B CZ3 1 
ATOM   5718 C CH2 . TRP   B 1 394 ? 2.30422   24.44039  24.48392  1.000 22.52296 ? 373 TRP   B CH2 1 
HETATM 5719 C C10 . A1D7D C 2 .   ? -1.62032  -3.41612  29.17786  1.000 24.49978 ? 401 A1D7D B C10 1 
HETATM 5720 C C15 . A1D7D C 2 .   ? -4.51064  -4.32826  28.97936  1.000 25.09505 ? 401 A1D7D B C15 1 
HETATM 5721 C C01 . A1D7D C 2 .   ? 4.19603   0.23886   26.31595  1.000 17.36873 ? 401 A1D7D B C01 1 
HETATM 5722 C C02 . A1D7D C 2 .   ? 3.85502   -1.17885  25.86755  1.000 27.93370 ? 401 A1D7D B C02 1 
HETATM 5723 C C03 . A1D7D C 2 .   ? 4.03035   -2.12365  27.05093  1.000 33.32059 ? 401 A1D7D B C03 1 
HETATM 5724 C C04 . A1D7D C 2 .   ? 2.95582   -2.22995  28.13791  1.000 25.22124 ? 401 A1D7D B C04 1 
HETATM 5725 C C05 . A1D7D C 2 .   ? 3.24376   -1.24100  29.27033  1.000 27.48457 ? 401 A1D7D B C05 1 
HETATM 5726 C C06 . A1D7D C 2 .   ? 1.96368   -0.54396  29.73352  1.000 23.85483 ? 401 A1D7D B C06 1 
HETATM 5727 C C07 . A1D7D C 2 .   ? 1.23268   -1.38671  30.77913  1.000 16.74415 ? 401 A1D7D B C07 1 
HETATM 5728 C C08 . A1D7D C 2 .   ? -0.17901  -1.70702  30.28687  1.000 24.17299 ? 401 A1D7D B C08 1 
HETATM 5729 C C09 . A1D7D C 2 .   ? -0.23768  -3.14232  29.76606  1.000 23.20084 ? 401 A1D7D B C09 1 
HETATM 5730 C C11 . A1D7D C 2 .   ? -2.17402  -4.71057  29.77010  1.000 24.96571 ? 401 A1D7D B C11 1 
HETATM 5731 C C12 . A1D7D C 2 .   ? -3.29796  -5.25065  28.88763  1.000 26.62977 ? 401 A1D7D B C12 1 
HETATM 5732 C C16 . A1D7D C 2 .   ? -5.78190  -5.12869  28.71116  1.000 32.43185 ? 401 A1D7D B C16 1 
HETATM 5733 O O13 . A1D7D C 2 .   ? 5.26811   0.69299   26.10561  1.000 17.97376 ? 401 A1D7D B O13 1 
HETATM 5734 O O14 . A1D7D C 2 .   ? 5.01843   -2.77044  27.12491  1.000 39.75545 ? 401 A1D7D B O14 1 
HETATM 5735 O O   . HOH   D 3 .   ? 10.26383  -9.26815  -6.64239  1.000 24.87162 ? 401 HOH   A O   1 
HETATM 5736 O O   . HOH   D 3 .   ? -8.11145  -19.55171 27.78543  1.000 44.30373 ? 402 HOH   A O   1 
HETATM 5737 O O   . HOH   D 3 .   ? -30.415   3.508     -1.453    1.000 29.80382 ? 403 HOH   A O   1 
HETATM 5738 O O   . HOH   D 3 .   ? -5.42985  -11.90713 -17.53005 1.000 36.89661 ? 404 HOH   A O   1 
HETATM 5739 O O   . HOH   D 3 .   ? 7.33494   9.66406   -0.10598  1.000 12.97103 ? 405 HOH   A O   1 
HETATM 5740 O O   . HOH   D 3 .   ? 12.51782  5.44424   -5.24082  1.000 18.79686 ? 406 HOH   A O   1 
HETATM 5741 O O   . HOH   D 3 .   ? -31.18796 7.43097   -12.96248 1.000 22.53978 ? 407 HOH   A O   1 
HETATM 5742 O O   . HOH   D 3 .   ? -11.40355 -34.90633 27.02319  1.000 35.14805 ? 408 HOH   A O   1 
HETATM 5743 O O   . HOH   D 3 .   ? -9.26376  8.61481   7.56955   1.000 16.59718 ? 409 HOH   A O   1 
HETATM 5744 O O   . HOH   D 3 .   ? -23.10700 -11.04645 -8.91514  1.000 16.03921 ? 410 HOH   A O   1 
HETATM 5745 O O   . HOH   D 3 .   ? -0.91758  -27.51168 15.98819  1.000 38.08249 ? 411 HOH   A O   1 
HETATM 5746 O O   . HOH   D 3 .   ? 18.58054  5.54334   2.32757   1.000 36.11411 ? 412 HOH   A O   1 
HETATM 5747 O O   . HOH   D 3 .   ? -13.54469 -6.26352  -18.52968 1.000 33.13470 ? 413 HOH   A O   1 
HETATM 5748 O O   . HOH   D 3 .   ? 0.40144   -32.50749 7.13054   1.000 36.13208 ? 414 HOH   A O   1 
HETATM 5749 O O   . HOH   D 3 .   ? 14.66816  -5.94151  -3.28776  1.000 22.58420 ? 415 HOH   A O   1 
HETATM 5750 O O   . HOH   D 3 .   ? 15.56833  -0.32157  11.26291  1.000 22.31161 ? 416 HOH   A O   1 
HETATM 5751 O O   . HOH   D 3 .   ? -33.21503 -6.55111  -0.88202  1.000 34.21145 ? 417 HOH   A O   1 
HETATM 5752 O O   . HOH   D 3 .   ? -4.65210  -5.42789  -16.42684 1.000 34.80677 ? 418 HOH   A O   1 
HETATM 5753 O O   . HOH   D 3 .   ? 5.32243   13.72929  5.79287   1.000 24.64243 ? 419 HOH   A O   1 
HETATM 5754 O O   . HOH   D 3 .   ? 14.25974  -7.57896  3.49010   1.000 36.59282 ? 420 HOH   A O   1 
HETATM 5755 O O   . HOH   D 3 .   ? -7.35090  -3.65843  -14.78839 1.000 23.88550 ? 421 HOH   A O   1 
HETATM 5756 O O   . HOH   D 3 .   ? -28.30490 -23.28990 19.89477  1.000 35.21280 ? 422 HOH   A O   1 
HETATM 5757 O O   . HOH   D 3 .   ? 12.39113  -6.21266  13.61097  1.000 27.67172 ? 423 HOH   A O   1 
HETATM 5758 O O   . HOH   D 3 .   ? 9.13008   -12.89738 15.34747  1.000 31.15897 ? 424 HOH   A O   1 
HETATM 5759 O O   . HOH   D 3 .   ? -22.53501 4.02985   -16.77575 1.000 18.72212 ? 425 HOH   A O   1 
HETATM 5760 O O   . HOH   D 3 .   ? -22.79767 -37.96140 3.46354   1.000 35.50523 ? 426 HOH   A O   1 
HETATM 5761 O O   . HOH   D 3 .   ? -7.52946  -7.10449  10.58314  1.000 8.99691  ? 427 HOH   A O   1 
HETATM 5762 O O   . HOH   D 3 .   ? -10.48177 9.36940   -0.51117  1.000 24.64900 ? 428 HOH   A O   1 
HETATM 5763 O O   . HOH   D 3 .   ? 11.48271  -16.45391 10.11925  1.000 34.98635 ? 429 HOH   A O   1 
HETATM 5764 O O   . HOH   D 3 .   ? -0.62836  -4.74552  -9.35212  1.000 18.14172 ? 430 HOH   A O   1 
HETATM 5765 O O   . HOH   D 3 .   ? 5.25664   15.93203  1.94781   1.000 25.94809 ? 431 HOH   A O   1 
HETATM 5766 O O   . HOH   D 3 .   ? -22.67509 -1.89365  16.66656  1.000 7.67515  ? 432 HOH   A O   1 
HETATM 5767 O O   . HOH   D 3 .   ? -2.11728  -11.32535 -9.88703  1.000 38.98151 ? 433 HOH   A O   1 
HETATM 5768 O O   . HOH   D 3 .   ? -23.66598 3.75705   14.02683  1.000 11.87275 ? 434 HOH   A O   1 
HETATM 5769 O O   . HOH   D 3 .   ? -16.53080 12.46592  -7.83151  1.000 18.88030 ? 435 HOH   A O   1 
HETATM 5770 O O   . HOH   D 3 .   ? -11.25164 -42.45344 24.95397  1.000 38.63998 ? 436 HOH   A O   1 
HETATM 5771 O O   . HOH   D 3 .   ? 6.03834   -27.73338 3.66777   1.000 30.20151 ? 437 HOH   A O   1 
HETATM 5772 O O   . HOH   D 3 .   ? -14.76153 -15.91814 -13.36276 1.000 30.80329 ? 438 HOH   A O   1 
HETATM 5773 O O   . HOH   D 3 .   ? -17.82097 11.81567  0.59699   1.000 24.27194 ? 439 HOH   A O   1 
HETATM 5774 O O   . HOH   D 3 .   ? -12.14529 -34.90976 3.24100   1.000 24.24124 ? 440 HOH   A O   1 
HETATM 5775 O O   . HOH   D 3 .   ? -15.54872 -19.64822 15.94260  1.000 19.84804 ? 441 HOH   A O   1 
HETATM 5776 O O   . HOH   D 3 .   ? -15.23224 -12.95106 12.43509  1.000 30.82714 ? 442 HOH   A O   1 
HETATM 5777 O O   . HOH   D 3 .   ? -28.67447 -2.43623  2.07606   1.000 11.29459 ? 443 HOH   A O   1 
HETATM 5778 O O   . HOH   D 3 .   ? -21.94377 -16.55891 -3.40699  1.000 35.24860 ? 444 HOH   A O   1 
HETATM 5779 O O   . HOH   D 3 .   ? -23.72996 -2.05421  -10.01501 1.000 22.42887 ? 445 HOH   A O   1 
HETATM 5780 O O   . HOH   D 3 .   ? 10.44550  -13.37054 0.03881   1.000 22.58062 ? 446 HOH   A O   1 
HETATM 5781 O O   . HOH   D 3 .   ? 13.58169  -2.45180  -9.83646  1.000 33.31899 ? 447 HOH   A O   1 
HETATM 5782 O O   . HOH   D 3 .   ? 15.15131  2.64572   11.73757  1.000 17.37016 ? 448 HOH   A O   1 
HETATM 5783 O O   . HOH   D 3 .   ? -12.15935 -20.65617 21.24537  1.000 21.70551 ? 449 HOH   A O   1 
HETATM 5784 O O   . HOH   D 3 .   ? -24.15035 -18.65368 16.89478  1.000 21.53229 ? 450 HOH   A O   1 
HETATM 5785 O O   . HOH   D 3 .   ? -16.60910 -19.69227 -4.10757  1.000 15.16902 ? 451 HOH   A O   1 
HETATM 5786 O O   . HOH   D 3 .   ? -32.49031 -8.28570  -6.01181  1.000 16.43859 ? 452 HOH   A O   1 
HETATM 5787 O O   . HOH   D 3 .   ? -0.90699  -23.22070 20.85193  1.000 29.70744 ? 453 HOH   A O   1 
HETATM 5788 O O   . HOH   D 3 .   ? 1.68545   -25.84251 -0.87970  1.000 18.09945 ? 454 HOH   A O   1 
HETATM 5789 O O   . HOH   D 3 .   ? 6.53601   15.28202  -6.92506  1.000 20.43345 ? 455 HOH   A O   1 
HETATM 5790 O O   . HOH   D 3 .   ? 4.64105   -21.42420 7.16447   1.000 21.23241 ? 456 HOH   A O   1 
HETATM 5791 O O   . HOH   D 3 .   ? -15.81952 -9.39308  19.65828  1.000 17.00932 ? 457 HOH   A O   1 
HETATM 5792 O O   . HOH   D 3 .   ? -16.32454 -8.57024  -5.97189  1.000 16.91892 ? 458 HOH   A O   1 
HETATM 5793 O O   . HOH   D 3 .   ? -15.49948 -20.04790 -8.39803  1.000 21.02260 ? 459 HOH   A O   1 
HETATM 5794 O O   . HOH   D 3 .   ? -1.50569  -27.86203 -2.41940  1.000 23.36557 ? 460 HOH   A O   1 
HETATM 5795 O O   . HOH   D 3 .   ? -17.73613 9.67281   2.33754   1.000 15.38212 ? 461 HOH   A O   1 
HETATM 5796 O O   . HOH   D 3 .   ? -35.04620 -1.48707  -3.85552  1.000 32.55386 ? 462 HOH   A O   1 
HETATM 5797 O O   . HOH   D 3 .   ? -22.45122 12.89805  -12.94977 1.000 29.73472 ? 463 HOH   A O   1 
HETATM 5798 O O   . HOH   D 3 .   ? -5.16897  -21.50419 19.04107  1.000 19.56308 ? 464 HOH   A O   1 
HETATM 5799 O O   . HOH   D 3 .   ? 9.70714   5.90148   12.43704  1.000 9.06943  ? 465 HOH   A O   1 
HETATM 5800 O O   . HOH   D 3 .   ? -10.97055 -5.75264  3.85047   1.000 6.06244  ? 466 HOH   A O   1 
HETATM 5801 O O   . HOH   D 3 .   ? -3.05470  13.54751  -3.21045  1.000 20.05738 ? 467 HOH   A O   1 
HETATM 5802 O O   . HOH   D 3 .   ? -19.95605 -21.37895 26.77449  1.000 41.36582 ? 468 HOH   A O   1 
HETATM 5803 O O   . HOH   D 3 .   ? -23.72768 7.06902   3.18262   1.000 20.82817 ? 469 HOH   A O   1 
HETATM 5804 O O   . HOH   D 3 .   ? -1.99671  -13.30586 -5.62630  1.000 18.83019 ? 470 HOH   A O   1 
HETATM 5805 O O   . HOH   D 3 .   ? -16.51970 -8.91564  -8.61880  1.000 21.26666 ? 471 HOH   A O   1 
HETATM 5806 O O   . HOH   D 3 .   ? 15.35658  10.22575  8.31213   1.000 20.73032 ? 472 HOH   A O   1 
HETATM 5807 O O   . HOH   D 3 .   ? -10.63520 -37.88312 8.99726   1.000 28.38041 ? 473 HOH   A O   1 
HETATM 5808 O O   . HOH   D 3 .   ? -13.88572 6.21466   5.49845   1.000 20.04266 ? 474 HOH   A O   1 
HETATM 5809 O O   . HOH   D 3 .   ? -16.77764 -9.97573  6.20456   1.000 18.23498 ? 475 HOH   A O   1 
HETATM 5810 O O   . HOH   D 3 .   ? -10.71090 -8.41214  2.69477   1.000 4.23195  ? 476 HOH   A O   1 
HETATM 5811 O O   . HOH   D 3 .   ? 11.40742  5.06009   4.26253   1.000 13.23428 ? 477 HOH   A O   1 
HETATM 5812 O O   . HOH   D 3 .   ? -22.09936 -33.59321 3.23246   1.000 28.00267 ? 478 HOH   A O   1 
HETATM 5813 O O   . HOH   D 3 .   ? -15.79480 -25.98981 -0.19280  1.000 13.70071 ? 479 HOH   A O   1 
HETATM 5814 O O   . HOH   D 3 .   ? -15.91011 -41.92251 24.43075  1.000 45.04642 ? 480 HOH   A O   1 
HETATM 5815 O O   . HOH   D 3 .   ? -1.24063  -6.33599  14.58855  1.000 14.59305 ? 481 HOH   A O   1 
HETATM 5816 O O   . HOH   D 3 .   ? -18.12083 2.69038   -15.23937 1.000 11.10492 ? 482 HOH   A O   1 
HETATM 5817 O O   . HOH   D 3 .   ? -13.15952 -19.57258 16.89090  1.000 19.43332 ? 483 HOH   A O   1 
HETATM 5818 O O   . HOH   D 3 .   ? -29.17756 -2.40703  -10.05979 1.000 27.76601 ? 484 HOH   A O   1 
HETATM 5819 O O   . HOH   D 3 .   ? -9.75208  -9.38582  20.90620  1.000 22.05065 ? 485 HOH   A O   1 
HETATM 5820 O O   . HOH   D 3 .   ? -17.45150 7.16064   -16.31135 1.000 35.52858 ? 486 HOH   A O   1 
HETATM 5821 O O   . HOH   D 3 .   ? 8.08270   9.58914   6.89422   1.000 19.18352 ? 487 HOH   A O   1 
HETATM 5822 O O   . HOH   D 3 .   ? -28.44781 1.08707   -6.00533  1.000 26.62044 ? 488 HOH   A O   1 
HETATM 5823 O O   . HOH   D 3 .   ? -25.56783 -1.99893  21.94778  1.000 22.53842 ? 489 HOH   A O   1 
HETATM 5824 O O   . HOH   D 3 .   ? 0.20968   -11.39760 -6.95917  1.000 39.94768 ? 490 HOH   A O   1 
HETATM 5825 O O   . HOH   D 3 .   ? -9.60208  -23.09564 -6.87109  1.000 22.21870 ? 491 HOH   A O   1 
HETATM 5826 O O   . HOH   D 3 .   ? -19.68409 -6.78603  15.24654  1.000 11.93260 ? 492 HOH   A O   1 
HETATM 5827 O O   . HOH   D 3 .   ? -19.49677 -32.72841 1.84909   1.000 20.95091 ? 493 HOH   A O   1 
HETATM 5828 O O   . HOH   D 3 .   ? -23.38071 -34.32922 21.95874  1.000 40.95479 ? 494 HOH   A O   1 
HETATM 5829 O O   . HOH   D 3 .   ? -7.75460  7.03861   -13.55382 1.000 30.54890 ? 495 HOH   A O   1 
HETATM 5830 O O   . HOH   D 3 .   ? -5.14109  -20.71264 -4.96289  1.000 21.51776 ? 496 HOH   A O   1 
HETATM 5831 O O   . HOH   D 3 .   ? -13.25740 -0.42019  -13.85229 1.000 12.90985 ? 497 HOH   A O   1 
HETATM 5832 O O   . HOH   D 3 .   ? 17.69575  2.68260   2.52885   1.000 29.12247 ? 498 HOH   A O   1 
HETATM 5833 O O   . HOH   D 3 .   ? 1.07607   -25.34748 7.64120   1.000 23.05862 ? 499 HOH   A O   1 
HETATM 5834 O O   . HOH   D 3 .   ? 0.78188   -6.83845  -10.94170 1.000 28.22135 ? 500 HOH   A O   1 
HETATM 5835 O O   . HOH   D 3 .   ? -27.58032 7.12890   1.88568   1.000 22.35348 ? 501 HOH   A O   1 
HETATM 5836 O O   . HOH   D 3 .   ? 2.89365   -22.96215 5.38550   1.000 15.48572 ? 502 HOH   A O   1 
HETATM 5837 O O   . HOH   D 3 .   ? -13.05250 -21.41526 18.81248  1.000 24.04497 ? 503 HOH   A O   1 
HETATM 5838 O O   . HOH   D 3 .   ? -16.20786 -10.47056 -10.94185 1.000 23.72958 ? 504 HOH   A O   1 
HETATM 5839 O O   . HOH   D 3 .   ? 16.05177  6.49259   -4.52813  1.000 24.17926 ? 505 HOH   A O   1 
HETATM 5840 O O   . HOH   D 3 .   ? -14.25390 4.43753   9.91337   1.000 12.47896 ? 506 HOH   A O   1 
HETATM 5841 O O   . HOH   D 3 .   ? -5.72828  8.03551   -19.12126 1.000 40.55333 ? 507 HOH   A O   1 
HETATM 5842 O O   . HOH   D 3 .   ? -0.24562  10.60053  -17.02872 1.000 40.15189 ? 508 HOH   A O   1 
HETATM 5843 O O   . HOH   D 3 .   ? -22.11167 -19.12059 12.62704  1.000 35.54135 ? 509 HOH   A O   1 
HETATM 5844 O O   . HOH   D 3 .   ? 3.49315   -27.53782 16.57274  1.000 30.66881 ? 510 HOH   A O   1 
HETATM 5845 O O   . HOH   D 3 .   ? -23.26161 -22.83640 -0.39042  1.000 32.54697 ? 511 HOH   A O   1 
HETATM 5846 O O   . HOH   D 3 .   ? -33.36543 -12.81820 5.71873   1.000 38.88115 ? 512 HOH   A O   1 
HETATM 5847 O O   . HOH   D 3 .   ? 4.49390   -18.23767 6.15046   1.000 30.09033 ? 513 HOH   A O   1 
HETATM 5848 O O   . HOH   D 3 .   ? -25.63105 -18.91116 19.20383  1.000 29.38586 ? 514 HOH   A O   1 
HETATM 5849 O O   . HOH   D 3 .   ? -10.67942 -19.61737 -10.34827 1.000 29.74485 ? 515 HOH   A O   1 
HETATM 5850 O O   . HOH   D 3 .   ? -7.91803  -5.71063  12.92294  1.000 7.51493  ? 516 HOH   A O   1 
HETATM 5851 O O   . HOH   D 3 .   ? -1.19967  -3.03306  12.66378  1.000 11.20499 ? 517 HOH   A O   1 
HETATM 5852 O O   . HOH   D 3 .   ? 3.14437   -13.86428 -6.68209  1.000 35.71641 ? 518 HOH   A O   1 
HETATM 5853 O O   . HOH   D 3 .   ? 8.49595   -7.82855  -7.90440  1.000 20.02772 ? 519 HOH   A O   1 
HETATM 5854 O O   . HOH   D 3 .   ? -31.63464 -11.82354 10.95168  1.000 34.79756 ? 520 HOH   A O   1 
HETATM 5855 O O   . HOH   D 3 .   ? -3.98392  -11.88748 -6.48268  1.000 13.90109 ? 521 HOH   A O   1 
HETATM 5856 O O   . HOH   D 3 .   ? 1.29120   -9.25711  -8.55005  1.000 26.71284 ? 522 HOH   A O   1 
HETATM 5857 O O   . HOH   D 3 .   ? -33.61903 -5.54568  2.06035   1.000 26.28994 ? 523 HOH   A O   1 
HETATM 5858 O O   . HOH   D 3 .   ? -17.71139 -36.74561 23.77053  1.000 34.81006 ? 524 HOH   A O   1 
HETATM 5859 O O   . HOH   D 3 .   ? 1.90426   -14.46688 -4.20075  1.000 16.39304 ? 525 HOH   A O   1 
HETATM 5860 O O   . HOH   D 3 .   ? -16.89498 7.92180   6.42785   1.000 10.53939 ? 526 HOH   A O   1 
HETATM 5861 O O   . HOH   D 3 .   ? -5.19423  -8.44851  18.10308  1.000 21.02626 ? 527 HOH   A O   1 
HETATM 5862 O O   . HOH   D 3 .   ? 6.94577   -17.88282 7.01706   1.000 32.17024 ? 528 HOH   A O   1 
HETATM 5863 O O   . HOH   D 3 .   ? -25.20142 -6.28056  -12.43765 1.000 20.98015 ? 529 HOH   A O   1 
HETATM 5864 O O   . HOH   D 3 .   ? -31.93546 -5.62665  -10.75831 1.000 34.87637 ? 530 HOH   A O   1 
HETATM 5865 O O   . HOH   D 3 .   ? -28.30156 -13.16504 -4.57388  1.000 27.60084 ? 531 HOH   A O   1 
HETATM 5866 O O   . HOH   D 3 .   ? -18.33588 -9.55289  19.46400  1.000 22.22530 ? 532 HOH   A O   1 
HETATM 5867 O O   . HOH   D 3 .   ? 8.26466   11.22083  10.67201  1.000 11.17140 ? 533 HOH   A O   1 
HETATM 5868 O O   . HOH   D 3 .   ? 7.14852   -15.30884 2.63408   1.000 13.76817 ? 534 HOH   A O   1 
HETATM 5869 O O   . HOH   D 3 .   ? -17.77130 -6.37547  -11.34566 1.000 12.09230 ? 535 HOH   A O   1 
HETATM 5870 O O   . HOH   D 3 .   ? -3.73153  -12.50066 12.20653  1.000 12.63759 ? 536 HOH   A O   1 
HETATM 5871 O O   . HOH   D 3 .   ? -12.13438 -39.68928 11.01603  1.000 32.42219 ? 537 HOH   A O   1 
HETATM 5872 O O   . HOH   D 3 .   ? -8.21046  -35.21196 -0.01018  1.000 25.00319 ? 538 HOH   A O   1 
HETATM 5873 O O   . HOH   D 3 .   ? 9.79052   -10.72059 -1.87890  1.000 19.52422 ? 539 HOH   A O   1 
HETATM 5874 O O   . HOH   D 3 .   ? -9.31069  -12.04583 -12.35363 1.000 25.35505 ? 540 HOH   A O   1 
HETATM 5875 O O   . HOH   D 3 .   ? -5.19837  -18.97164 1.94322   1.000 14.00334 ? 541 HOH   A O   1 
HETATM 5876 O O   . HOH   D 3 .   ? -15.85413 13.56524  -3.86612  1.000 29.46281 ? 542 HOH   A O   1 
HETATM 5877 O O   . HOH   D 3 .   ? -10.02692 -21.70524 9.77412   1.000 10.78468 ? 543 HOH   A O   1 
HETATM 5878 O O   . HOH   D 3 .   ? -7.13595  -24.07058 -5.91396  1.000 25.46863 ? 544 HOH   A O   1 
HETATM 5879 O O   . HOH   D 3 .   ? -26.15926 -15.87653 -8.02220  1.000 28.48719 ? 545 HOH   A O   1 
HETATM 5880 O O   . HOH   D 3 .   ? -12.77776 -8.17768  21.24736  1.000 16.69732 ? 546 HOH   A O   1 
HETATM 5881 O O   . HOH   D 3 .   ? -11.32091 11.15875  0.94346   1.000 34.99586 ? 547 HOH   A O   1 
HETATM 5882 O O   . HOH   D 3 .   ? -26.63954 12.50731  -6.93433  1.000 35.39122 ? 548 HOH   A O   1 
HETATM 5883 O O   . HOH   D 3 .   ? 3.25197   4.65229   -12.72920 1.000 25.16954 ? 549 HOH   A O   1 
HETATM 5884 O O   . HOH   D 3 .   ? 5.62111   -20.50920 4.76211   1.000 22.24197 ? 550 HOH   A O   1 
HETATM 5885 O O   . HOH   D 3 .   ? -16.04835 1.27356   8.41621   1.000 7.31887  ? 551 HOH   A O   1 
HETATM 5886 O O   . HOH   D 3 .   ? 16.04429  2.64670   0.31337   1.000 21.38650 ? 552 HOH   A O   1 
HETATM 5887 O O   . HOH   D 3 .   ? -9.78326  -14.21784 -7.87062  1.000 11.53921 ? 553 HOH   A O   1 
HETATM 5888 O O   . HOH   D 3 .   ? -14.39698 -39.28745 8.96691   1.000 32.85069 ? 554 HOH   A O   1 
HETATM 5889 O O   . HOH   D 3 .   ? -15.39077 12.61985  1.44906   1.000 26.75674 ? 555 HOH   A O   1 
HETATM 5890 O O   . HOH   D 3 .   ? -27.66518 -17.09917 0.41499   1.000 28.88004 ? 556 HOH   A O   1 
HETATM 5891 O O   . HOH   D 3 .   ? -24.74906 -6.92762  19.34465  1.000 22.81968 ? 557 HOH   A O   1 
HETATM 5892 O O   . HOH   D 3 .   ? 5.65572   -15.77440 0.53606   1.000 21.08957 ? 558 HOH   A O   1 
HETATM 5893 O O   . HOH   D 3 .   ? -18.71734 -1.50503  17.79373  1.000 30.97508 ? 559 HOH   A O   1 
HETATM 5894 O O   . HOH   D 3 .   ? -26.48395 -1.87987  -9.11756  1.000 18.53023 ? 560 HOH   A O   1 
HETATM 5895 O O   . HOH   D 3 .   ? -18.63451 -11.24751 21.28383  1.000 30.16628 ? 561 HOH   A O   1 
HETATM 5896 O O   . HOH   D 3 .   ? 0.76535   -4.81206  13.67204  1.000 8.34265  ? 562 HOH   A O   1 
HETATM 5897 O O   . HOH   D 3 .   ? -14.34822 -2.02630  13.91635  1.000 12.63134 ? 563 HOH   A O   1 
HETATM 5898 O O   . HOH   D 3 .   ? -6.13866  13.52618  -10.85333 1.000 35.61362 ? 564 HOH   A O   1 
HETATM 5899 O O   . HOH   D 3 .   ? -13.60448 -9.32062  -11.75412 1.000 25.03642 ? 565 HOH   A O   1 
HETATM 5900 O O   . HOH   D 3 .   ? -11.96763 -4.52941  -20.67290 1.000 37.48592 ? 566 HOH   A O   1 
HETATM 5901 O O   . HOH   D 3 .   ? -15.83129 -37.28823 4.30937   1.000 32.93411 ? 567 HOH   A O   1 
HETATM 5902 O O   . HOH   D 3 .   ? -15.25593 -30.84494 1.71928   1.000 30.81970 ? 568 HOH   A O   1 
HETATM 5903 O O   . HOH   D 3 .   ? -24.13569 -20.12149 14.83594  1.000 23.93076 ? 569 HOH   A O   1 
HETATM 5904 O O   . HOH   D 3 .   ? 10.64520  9.49899   1.78629   1.000 30.28353 ? 570 HOH   A O   1 
HETATM 5905 O O   . HOH   D 3 .   ? -31.08050 3.00577   -8.69017  1.000 31.20681 ? 571 HOH   A O   1 
HETATM 5906 O O   . HOH   D 3 .   ? 2.58532   -10.40658 20.68425  1.000 19.08728 ? 572 HOH   A O   1 
HETATM 5907 O O   . HOH   D 3 .   ? -8.23216  7.99293   -17.72712 1.000 34.91079 ? 573 HOH   A O   1 
HETATM 5908 O O   . HOH   D 3 .   ? 6.86819   -20.93999 11.61161  1.000 32.55050 ? 574 HOH   A O   1 
HETATM 5909 O O   . HOH   D 3 .   ? 8.11883   5.21423   14.44517  1.000 14.37623 ? 575 HOH   A O   1 
HETATM 5910 O O   . HOH   D 3 .   ? -26.77804 7.47646   -6.41191  1.000 32.62910 ? 576 HOH   A O   1 
HETATM 5911 O O   . HOH   D 3 .   ? 17.51556  3.02286   8.09877   1.000 26.18628 ? 577 HOH   A O   1 
HETATM 5912 O O   . HOH   D 3 .   ? -18.613   -5.340    -16.127   1.000 27.19217 ? 578 HOH   A O   1 
HETATM 5913 O O   . HOH   D 3 .   ? 3.38314   -15.83728 -2.33529  1.000 22.28916 ? 579 HOH   A O   1 
HETATM 5914 O O   . HOH   D 3 .   ? 15.49379  -9.61634  6.35191   1.000 26.89686 ? 580 HOH   A O   1 
HETATM 5915 O O   . HOH   D 3 .   ? 3.38285   16.22092  -0.20181  1.000 15.16869 ? 581 HOH   A O   1 
HETATM 5916 O O   . HOH   D 3 .   ? 17.11778  7.49982   8.16427   1.000 20.13886 ? 582 HOH   A O   1 
HETATM 5917 O O   . HOH   D 3 .   ? 12.11080  13.13467  8.01754   1.000 27.49380 ? 583 HOH   A O   1 
HETATM 5918 O O   . HOH   D 3 .   ? -14.93128 -33.09675 3.17939   1.000 26.82864 ? 584 HOH   A O   1 
HETATM 5919 O O   . HOH   D 3 .   ? -10.49972 -29.73524 -2.06832  1.000 15.95006 ? 585 HOH   A O   1 
HETATM 5920 O O   . HOH   D 3 .   ? -30.22121 -9.78666  -8.27847  1.000 25.06624 ? 586 HOH   A O   1 
HETATM 5921 O O   . HOH   D 3 .   ? -15.39180 -8.46514  23.13814  1.000 25.46272 ? 587 HOH   A O   1 
HETATM 5922 O O   . HOH   D 3 .   ? 10.39882  -12.85411 4.09730   1.000 15.12936 ? 588 HOH   A O   1 
HETATM 5923 O O   . HOH   D 3 .   ? -22.45282 -4.46948  22.95321  1.000 22.52336 ? 589 HOH   A O   1 
HETATM 5924 O O   . HOH   D 3 .   ? 1.76353   -29.39825 8.86752   1.000 31.99187 ? 590 HOH   A O   1 
HETATM 5925 O O   . HOH   D 3 .   ? 9.60142   -1.96522  -13.16493 1.000 34.77832 ? 591 HOH   A O   1 
HETATM 5926 O O   . HOH   D 3 .   ? 2.40836   -10.58758 -6.04425  1.000 8.77619  ? 592 HOH   A O   1 
HETATM 5927 O O   . HOH   D 3 .   ? -25.27255 10.73233  1.76389   1.000 20.73139 ? 593 HOH   A O   1 
HETATM 5928 O O   . HOH   D 3 .   ? -0.40529  -4.37609  -14.19695 1.000 31.87607 ? 594 HOH   A O   1 
HETATM 5929 O O   . HOH   D 3 .   ? -15.83152 3.31661   -19.15450 1.000 21.52535 ? 595 HOH   A O   1 
HETATM 5930 O O   . HOH   D 3 .   ? -30.45244 -17.21897 13.32349  1.000 29.62552 ? 596 HOH   A O   1 
HETATM 5931 O O   . HOH   D 3 .   ? -13.39049 13.81765  2.91262   1.000 34.58830 ? 597 HOH   A O   1 
HETATM 5932 O O   . HOH   D 3 .   ? 7.92144   2.29317   -12.37210 1.000 37.55951 ? 598 HOH   A O   1 
HETATM 5933 O O   . HOH   D 3 .   ? -15.25835 -26.65019 -6.90734  1.000 28.94689 ? 599 HOH   A O   1 
HETATM 5934 O O   . HOH   D 3 .   ? -24.95854 -28.57663 7.07395   1.000 33.50038 ? 600 HOH   A O   1 
HETATM 5935 O O   . HOH   D 3 .   ? -23.164   -2.662    -12.086   1.000 23.03568 ? 601 HOH   A O   1 
HETATM 5936 O O   . HOH   D 3 .   ? -35.475   -3.393    -2.420    1.000 28.22227 ? 602 HOH   A O   1 
HETATM 5937 O O   . HOH   D 3 .   ? -5.61988  -34.64712 6.34634   1.000 30.02355 ? 603 HOH   A O   1 
HETATM 5938 O O   . HOH   D 3 .   ? -20.32013 -17.13704 23.27778  1.000 36.97942 ? 604 HOH   A O   1 
HETATM 5939 O O   . HOH   D 3 .   ? -23.91886 -4.05395  20.45568  1.000 16.44717 ? 605 HOH   A O   1 
HETATM 5940 O O   . HOH   D 3 .   ? 15.06616  -7.76672  11.38019  1.000 34.34550 ? 606 HOH   A O   1 
HETATM 5941 O O   . HOH   D 3 .   ? 13.209    -4.780    0.281     1.000 24.35312 ? 607 HOH   A O   1 
HETATM 5942 O O   . HOH   D 3 .   ? 10.29898  -6.79450  -9.77610  1.000 27.21327 ? 608 HOH   A O   1 
HETATM 5943 O O   . HOH   D 3 .   ? -6.41553  -2.45937  -18.30532 1.000 40.25469 ? 609 HOH   A O   1 
HETATM 5944 O O   . HOH   D 3 .   ? 8.22468   11.71779  -1.91104  1.000 24.39954 ? 610 HOH   A O   1 
HETATM 5945 O O   . HOH   D 3 .   ? -30.28340 -0.89663  -5.42843  1.000 24.26862 ? 611 HOH   A O   1 
HETATM 5946 O O   . HOH   D 3 .   ? -16.99541 -26.79597 -2.87753  1.000 27.70238 ? 612 HOH   A O   1 
HETATM 5947 O O   . HOH   D 3 .   ? -19.931   -26.665   -3.114    1.000 26.54835 ? 613 HOH   A O   1 
HETATM 5948 O O   . HOH   D 3 .   ? -26.365   11.311    -11.719   1.000 23.62800 ? 614 HOH   A O   1 
HETATM 5949 O O   . HOH   D 3 .   ? -13.11692 -11.09862 13.39022  1.000 23.47808 ? 615 HOH   A O   1 
HETATM 5950 O O   . HOH   D 3 .   ? -17.80333 4.51604   -17.52753 1.000 25.14740 ? 616 HOH   A O   1 
HETATM 5951 O O   . HOH   D 3 .   ? -18.48954 -7.03594  -13.74809 1.000 30.00625 ? 617 HOH   A O   1 
HETATM 5952 O O   . HOH   D 3 .   ? 12.67303  -17.01393 12.73992  1.000 27.09757 ? 618 HOH   A O   1 
HETATM 5953 O O   . HOH   D 3 .   ? -31.492   9.951     -10.703   1.000 33.69408 ? 619 HOH   A O   1 
HETATM 5954 O O   . HOH   D 3 .   ? -29.84290 -12.04242 -6.45860  1.000 25.72764 ? 620 HOH   A O   1 
HETATM 5955 O O   . HOH   D 3 .   ? -12.93443 -37.10742 1.93486   1.000 30.55179 ? 621 HOH   A O   1 
HETATM 5956 O O   . HOH   D 3 .   ? -17.09160 -21.01936 -6.20603  1.000 17.62460 ? 622 HOH   A O   1 
HETATM 5957 O O   . HOH   D 3 .   ? -13.26779 -21.36524 -9.20932  1.000 23.50009 ? 623 HOH   A O   1 
HETATM 5958 O O   . HOH   D 3 .   ? 8.19774   -19.08768 12.82606  1.000 31.97919 ? 624 HOH   A O   1 
HETATM 5959 O O   . HOH   D 3 .   ? 0.350     -32.199   26.349    1.000 35.83415 ? 625 HOH   A O   1 
HETATM 5960 O O   . HOH   D 3 .   ? -29.268   -15.657   -12.318   1.000 33.91710 ? 626 HOH   A O   1 
HETATM 5961 O O   . HOH   D 3 .   ? -29.33080 -7.05746  -14.18303 1.000 28.93299 ? 627 HOH   A O   1 
HETATM 5962 O O   . HOH   D 3 .   ? 10.90226  -8.40244  15.13579  1.000 11.80956 ? 628 HOH   A O   1 
HETATM 5963 O O   . HOH   D 3 .   ? 16.003    -3.155    -10.955   1.000 33.37244 ? 629 HOH   A O   1 
HETATM 5964 O O   . HOH   D 3 .   ? -18.08137 -35.36666 1.84675   1.000 18.85394 ? 630 HOH   A O   1 
HETATM 5965 O O   . HOH   D 3 .   ? -29.28385 -14.69029 1.00843   1.000 46.28051 ? 631 HOH   A O   1 
HETATM 5966 O O   . HOH   D 3 .   ? -6.22947  5.14892   -19.65165 1.000 32.77038 ? 632 HOH   A O   1 
HETATM 5967 O O   . HOH   D 3 .   ? 19.189    7.742     10.643    1.000 30.18664 ? 633 HOH   A O   1 
HETATM 5968 O O   . HOH   D 3 .   ? -10.05654 -14.19383 -10.55969 1.000 23.24235 ? 634 HOH   A O   1 
HETATM 5969 O O   . HOH   D 3 .   ? -24.120   -8.395    -16.711   1.000 33.13275 ? 635 HOH   A O   1 
HETATM 5970 O O   . HOH   D 3 .   ? -10.06215 -36.66750 -1.54078  1.000 30.02341 ? 636 HOH   A O   1 
HETATM 5971 O O   . HOH   D 3 .   ? -27.81942 -7.68741  -16.38692 1.000 31.99301 ? 637 HOH   A O   1 
HETATM 5972 O O   . HOH   D 3 .   ? -8.258    -44.457   22.232    1.000 29.86189 ? 638 HOH   A O   1 
HETATM 5973 O O   . HOH   D 3 .   ? -26.95106 -23.88741 14.37706  1.000 32.73214 ? 639 HOH   A O   1 
HETATM 5974 O O   . HOH   D 3 .   ? -29.833   -1.751    -13.511   1.000 28.67873 ? 640 HOH   A O   1 
HETATM 5975 O O   . HOH   D 3 .   ? 6.14788   -17.01512 4.88351   1.000 25.06944 ? 641 HOH   A O   1 
HETATM 5976 O O   . HOH   D 3 .   ? -25.75630 7.99493   5.76433   1.000 24.39092 ? 642 HOH   A O   1 
HETATM 5977 O O   . HOH   D 3 .   ? -30.10187 -14.56987 -3.44591  1.000 34.14060 ? 643 HOH   A O   1 
HETATM 5978 O O   . HOH   D 3 .   ? 9.91638   10.80588  -3.66263  1.000 26.61116 ? 644 HOH   A O   1 
HETATM 5979 O O   . HOH   D 3 .   ? 1.01290   -11.17264 -10.35372 1.000 32.63479 ? 645 HOH   A O   1 
HETATM 5980 O O   . HOH   D 3 .   ? 12.68504  -7.99837  -10.49130 1.000 30.45443 ? 646 HOH   A O   1 
HETATM 5981 O O   . HOH   D 3 .   ? -6.77851  -36.31320 4.25451   1.000 25.35062 ? 647 HOH   A O   1 
HETATM 5982 O O   . HOH   D 3 .   ? -19.05083 -18.63896 -3.05437  1.000 20.08962 ? 648 HOH   A O   1 
HETATM 5983 O O   . HOH   D 3 .   ? -23.985   -40.096   5.616     1.000 27.25356 ? 649 HOH   A O   1 
HETATM 5984 O O   . HOH   D 3 .   ? -26.81437 -21.29415 14.05008  1.000 29.68795 ? 650 HOH   A O   1 
HETATM 5985 O O   . HOH   D 3 .   ? -20.00360 5.64761   -18.11674 1.000 31.31997 ? 651 HOH   A O   1 
HETATM 5986 O O   . HOH   D 3 .   ? 7.34169   -12.89770 20.00344  1.000 30.26029 ? 652 HOH   A O   1 
HETATM 5987 O O   . HOH   D 3 .   ? -24.18495 -4.26031  25.28336  1.000 39.01893 ? 653 HOH   A O   1 
HETATM 5988 O O   . HOH   D 3 .   ? -1.38705  -7.52067  22.15000  1.000 24.64996 ? 654 HOH   A O   1 
HETATM 5989 O O   . HOH   D 3 .   ? -16.14209 -12.20455 10.00815  1.000 36.55022 ? 655 HOH   A O   1 
HETATM 5990 O O   . HOH   D 3 .   ? -17.80424 13.88728  2.42064   1.000 35.49413 ? 656 HOH   A O   1 
HETATM 5991 O O   . HOH   D 3 .   ? -7.43696  -41.14934 13.30271  1.000 37.71893 ? 657 HOH   A O   1 
HETATM 5992 O O   . HOH   D 3 .   ? 4.31065   2.42338   -11.50202 1.000 30.21946 ? 658 HOH   A O   1 
HETATM 5993 O O   . HOH   D 3 .   ? 9.95967   -12.81776 -3.26594  1.000 27.11535 ? 659 HOH   A O   1 
HETATM 5994 O O   . HOH   D 3 .   ? -14.68335 -22.48177 -11.34224 1.000 39.42920 ? 660 HOH   A O   1 
HETATM 5995 O O   . HOH   D 3 .   ? -10.806   11.854    -22.907   1.000 36.24322 ? 661 HOH   A O   1 
HETATM 5996 O O   . HOH   D 3 .   ? -28.01025 6.81216   6.69027   1.000 26.88327 ? 662 HOH   A O   1 
HETATM 5997 O O   . HOH   D 3 .   ? -25.58816 -21.50929 11.27596  1.000 30.02814 ? 663 HOH   A O   1 
HETATM 5998 O O   . HOH   D 3 .   ? 15.00223  -18.01063 12.27069  1.000 38.85019 ? 664 HOH   A O   1 
HETATM 5999 O O   . HOH   E 3 .   ? -2.18641  19.98831  10.79113  1.000 25.91363 ? 501 HOH   B O   1 
HETATM 6000 O O   . HOH   E 3 .   ? -19.07441 17.35453  32.11181  1.000 21.82861 ? 502 HOH   B O   1 
HETATM 6001 O O   . HOH   E 3 .   ? 6.95311   -2.10244  28.46305  1.000 23.61681 ? 503 HOH   B O   1 
HETATM 6002 O O   . HOH   E 3 .   ? -2.28585  30.37729  18.78774  1.000 31.17351 ? 504 HOH   B O   1 
HETATM 6003 O O   . HOH   E 3 .   ? 12.86016  11.94606  37.20179  1.000 31.13778 ? 505 HOH   B O   1 
HETATM 6004 O O   . HOH   E 3 .   ? 18.53159  -8.19455  47.96913  1.000 35.89099 ? 506 HOH   B O   1 
HETATM 6005 O O   . HOH   E 3 .   ? -14.12548 13.91680  6.03661   1.000 24.34881 ? 507 HOH   B O   1 
HETATM 6006 O O   . HOH   E 3 .   ? 26.57279  13.88147  23.48921  1.000 30.05900 ? 508 HOH   B O   1 
HETATM 6007 O O   . HOH   E 3 .   ? -3.66367  -7.70443  50.70912  1.000 30.29883 ? 509 HOH   B O   1 
HETATM 6008 O O   . HOH   E 3 .   ? 16.98940  -6.67613  14.47455  1.000 25.18161 ? 510 HOH   B O   1 
HETATM 6009 O O   . HOH   E 3 .   ? 0.14208   20.35859  11.78063  1.000 15.97698 ? 511 HOH   B O   1 
HETATM 6010 O O   . HOH   E 3 .   ? 9.79169   -13.39441 49.40945  1.000 20.89432 ? 512 HOH   B O   1 
HETATM 6011 O O   . HOH   E 3 .   ? -21.48198 20.86302  17.46431  1.000 15.97437 ? 513 HOH   B O   1 
HETATM 6012 O O   . HOH   E 3 .   ? 0.57783   10.73371  9.89989   1.000 16.39887 ? 514 HOH   B O   1 
HETATM 6013 O O   . HOH   E 3 .   ? 19.99546  11.75427  22.06670  1.000 20.32630 ? 515 HOH   B O   1 
HETATM 6014 O O   . HOH   E 3 .   ? 16.46616  2.18121   31.92150  1.000 27.79620 ? 516 HOH   B O   1 
HETATM 6015 O O   . HOH   E 3 .   ? 1.60360   16.97296  42.12499  1.000 28.57611 ? 517 HOH   B O   1 
HETATM 6016 O O   . HOH   E 3 .   ? 13.46170  30.25958  8.03138   1.000 43.42911 ? 518 HOH   B O   1 
HETATM 6017 O O   . HOH   E 3 .   ? -9.11315  19.91019  31.89010  1.000 22.50283 ? 519 HOH   B O   1 
HETATM 6018 O O   . HOH   E 3 .   ? 14.90930  29.33137  18.32210  1.000 27.58770 ? 520 HOH   B O   1 
HETATM 6019 O O   . HOH   E 3 .   ? 9.58709   18.20816  9.34269   1.000 23.26924 ? 521 HOH   B O   1 
HETATM 6020 O O   . HOH   E 3 .   ? 7.12577   17.54563  8.51437   1.000 37.39725 ? 522 HOH   B O   1 
HETATM 6021 O O   . HOH   E 3 .   ? 10.86918  3.51680   32.21673  1.000 27.53869 ? 523 HOH   B O   1 
HETATM 6022 O O   . HOH   E 3 .   ? -7.49786  -1.71488  21.67539  1.000 11.95374 ? 524 HOH   B O   1 
HETATM 6023 O O   . HOH   E 3 .   ? 14.10090  18.91895  33.50285  1.000 25.13985 ? 525 HOH   B O   1 
HETATM 6024 O O   . HOH   E 3 .   ? -3.01472  -10.92394 33.80858  1.000 19.69037 ? 526 HOH   B O   1 
HETATM 6025 O O   . HOH   E 3 .   ? 17.05389  -10.55577 31.26558  1.000 35.83339 ? 527 HOH   B O   1 
HETATM 6026 O O   . HOH   E 3 .   ? -5.65081  19.37230  37.06448  1.000 33.36465 ? 528 HOH   B O   1 
HETATM 6027 O O   . HOH   E 3 .   ? -0.40836  18.95527  39.32353  1.000 26.00317 ? 529 HOH   B O   1 
HETATM 6028 O O   . HOH   E 3 .   ? 5.85391   -14.71799 31.12898  1.000 31.02618 ? 530 HOH   B O   1 
HETATM 6029 O O   . HOH   E 3 .   ? -22.96098 21.47553  12.78204  1.000 30.64751 ? 531 HOH   B O   1 
HETATM 6030 O O   . HOH   E 3 .   ? 18.12814  -9.59256  45.68672  1.000 20.30599 ? 532 HOH   B O   1 
HETATM 6031 O O   . HOH   E 3 .   ? 1.78505   29.16795  30.38191  1.000 35.70049 ? 533 HOH   B O   1 
HETATM 6032 O O   . HOH   E 3 .   ? 15.90502  -22.97865 36.59507  1.000 27.66614 ? 534 HOH   B O   1 
HETATM 6033 O O   . HOH   E 3 .   ? 3.86157   -19.85796 38.07473  1.000 24.06246 ? 535 HOH   B O   1 
HETATM 6034 O O   . HOH   E 3 .   ? 26.34094  17.06652  23.44565  1.000 20.90666 ? 536 HOH   B O   1 
HETATM 6035 O O   . HOH   E 3 .   ? -16.11756 17.83782  11.97006  1.000 11.96547 ? 537 HOH   B O   1 
HETATM 6036 O O   . HOH   E 3 .   ? -1.39593  28.39016  27.08192  1.000 26.63270 ? 538 HOH   B O   1 
HETATM 6037 O O   . HOH   E 3 .   ? 4.39367   23.65900  31.13021  1.000 18.67122 ? 539 HOH   B O   1 
HETATM 6038 O O   . HOH   E 3 .   ? -21.41799 18.11728  11.12719  1.000 24.63184 ? 540 HOH   B O   1 
HETATM 6039 O O   . HOH   E 3 .   ? 7.47488   -7.25127  33.20593  1.000 13.07008 ? 541 HOH   B O   1 
HETATM 6040 O O   . HOH   E 3 .   ? -8.58194  17.35832  34.04682  1.000 17.78094 ? 542 HOH   B O   1 
HETATM 6041 O O   . HOH   E 3 .   ? -12.00990 23.68475  26.97402  1.000 22.44012 ? 543 HOH   B O   1 
HETATM 6042 O O   . HOH   E 3 .   ? -6.81198  14.79056  35.37128  1.000 14.50883 ? 544 HOH   B O   1 
HETATM 6043 O O   . HOH   E 3 .   ? -9.89354  -9.41652  36.66407  1.000 21.83999 ? 545 HOH   B O   1 
HETATM 6044 O O   . HOH   E 3 .   ? 2.56538   -6.84454  52.88826  1.000 19.16118 ? 546 HOH   B O   1 
HETATM 6045 O O   . HOH   E 3 .   ? -0.96204  2.06569   23.54707  1.000 11.42914 ? 547 HOH   B O   1 
HETATM 6046 O O   . HOH   E 3 .   ? -6.85434  -13.16510 34.84500  1.000 20.43131 ? 548 HOH   B O   1 
HETATM 6047 O O   . HOH   E 3 .   ? 3.42803   17.56241  9.82303   1.000 28.10921 ? 549 HOH   B O   1 
HETATM 6048 O O   . HOH   E 3 .   ? 16.28623  30.36302  15.92478  1.000 38.02105 ? 550 HOH   B O   1 
HETATM 6049 O O   . HOH   E 3 .   ? 9.39056   29.74377  22.73723  1.000 26.96808 ? 551 HOH   B O   1 
HETATM 6050 O O   . HOH   E 3 .   ? -19.81811 14.19293  11.28085  1.000 35.83314 ? 552 HOH   B O   1 
HETATM 6051 O O   . HOH   E 3 .   ? 0.28885   1.93391   53.27390  1.000 14.63202 ? 553 HOH   B O   1 
HETATM 6052 O O   . HOH   E 3 .   ? -23.05975 14.20874  31.55470  1.000 30.20785 ? 554 HOH   B O   1 
HETATM 6053 O O   . HOH   E 3 .   ? 16.28980  -8.26596  53.16450  1.000 29.41507 ? 555 HOH   B O   1 
HETATM 6054 O O   . HOH   E 3 .   ? -14.40620 7.15904   38.15177  1.000 33.29068 ? 556 HOH   B O   1 
HETATM 6055 O O   . HOH   E 3 .   ? 13.07102  -9.05093  25.90699  1.000 27.45706 ? 557 HOH   B O   1 
HETATM 6056 O O   . HOH   E 3 .   ? -19.31366 23.94857  28.10460  1.000 37.24150 ? 558 HOH   B O   1 
HETATM 6057 O O   . HOH   E 3 .   ? -17.74072 14.80725  8.97414   1.000 35.05695 ? 559 HOH   B O   1 
HETATM 6058 O O   . HOH   E 3 .   ? -17.39706 20.53842  14.50824  1.000 18.31253 ? 560 HOH   B O   1 
HETATM 6059 O O   . HOH   E 3 .   ? -6.20223  20.04431  34.43124  1.000 39.82656 ? 561 HOH   B O   1 
HETATM 6060 O O   . HOH   E 3 .   ? -3.53201  33.04896  31.97832  1.000 34.58249 ? 562 HOH   B O   1 
HETATM 6061 O O   . HOH   E 3 .   ? -6.43624  6.10718   48.44541  1.000 21.27024 ? 563 HOH   B O   1 
HETATM 6062 O O   . HOH   E 3 .   ? 5.83456   -9.65342  54.16744  1.000 24.65459 ? 564 HOH   B O   1 
HETATM 6063 O O   . HOH   E 3 .   ? -9.975    5.489     45.788    1.000 16.33184 ? 565 HOH   B O   1 
HETATM 6064 O O   . HOH   E 3 .   ? 7.60393   -12.49005 26.01291  1.000 34.10523 ? 566 HOH   B O   1 
HETATM 6065 O O   . HOH   E 3 .   ? -5.99132  -16.74856 36.05034  1.000 36.32388 ? 567 HOH   B O   1 
HETATM 6066 O O   . HOH   E 3 .   ? -4.74082  16.40717  33.93806  1.000 12.16183 ? 568 HOH   B O   1 
HETATM 6067 O O   . HOH   E 3 .   ? -21.07996 1.11609   31.64193  1.000 24.20442 ? 569 HOH   B O   1 
HETATM 6068 O O   . HOH   E 3 .   ? -23.41299 15.27605  27.31246  1.000 23.81053 ? 570 HOH   B O   1 
HETATM 6069 O O   . HOH   E 3 .   ? 10.43015  3.74865   50.84215  1.000 33.17686 ? 571 HOH   B O   1 
HETATM 6070 O O   . HOH   E 3 .   ? -12.29821 16.11486  35.64147  1.000 28.57668 ? 572 HOH   B O   1 
HETATM 6071 O O   . HOH   E 3 .   ? -18.46780 4.62791   10.72927  1.000 10.66095 ? 573 HOH   B O   1 
HETATM 6072 O O   . HOH   E 3 .   ? 2.19170   -22.32708 43.50185  1.000 32.97929 ? 574 HOH   B O   1 
HETATM 6073 O O   . HOH   E 3 .   ? 1.52973   17.93214  11.56379  1.000 31.54747 ? 575 HOH   B O   1 
HETATM 6074 O O   . HOH   E 3 .   ? 5.26945   6.94009   12.78788  1.000 17.30038 ? 576 HOH   B O   1 
HETATM 6075 O O   . HOH   E 3 .   ? -3.23617  6.05866   37.70901  1.000 7.21401  ? 577 HOH   B O   1 
HETATM 6076 O O   . HOH   E 3 .   ? 5.02899   8.75287   48.61279  1.000 27.37049 ? 578 HOH   B O   1 
HETATM 6077 O O   . HOH   E 3 .   ? 11.19763  -1.87795  21.52508  1.000 11.62892 ? 579 HOH   B O   1 
HETATM 6078 O O   . HOH   E 3 .   ? 7.50519   5.78705   44.66088  1.000 13.83036 ? 580 HOH   B O   1 
HETATM 6079 O O   . HOH   E 3 .   ? 22.44910  -13.47623 36.37696  1.000 41.65213 ? 581 HOH   B O   1 
HETATM 6080 O O   . HOH   E 3 .   ? 18.67267  -5.91594  42.47183  1.000 44.18317 ? 582 HOH   B O   1 
HETATM 6081 O O   . HOH   E 3 .   ? 0.87266   16.81467  36.80661  1.000 14.77981 ? 583 HOH   B O   1 
HETATM 6082 O O   . HOH   E 3 .   ? 15.18520  -22.05977 33.86215  1.000 27.75635 ? 584 HOH   B O   1 
HETATM 6083 O O   . HOH   E 3 .   ? 14.60980  -18.38281 44.64615  1.000 23.76037 ? 585 HOH   B O   1 
HETATM 6084 O O   . HOH   E 3 .   ? -4.83739  -1.25534  28.14912  1.000 11.30979 ? 586 HOH   B O   1 
HETATM 6085 O O   . HOH   E 3 .   ? 9.18485   15.80100  10.19762  1.000 23.27357 ? 587 HOH   B O   1 
HETATM 6086 O O   . HOH   E 3 .   ? -9.34744  -1.37163  42.03847  1.000 20.89653 ? 588 HOH   B O   1 
HETATM 6087 O O   . HOH   E 3 .   ? 1.08010   -8.40691  22.20165  1.000 20.41548 ? 589 HOH   B O   1 
HETATM 6088 O O   . HOH   E 3 .   ? -20.06624 11.94447  14.29788  1.000 9.36993  ? 590 HOH   B O   1 
HETATM 6089 O O   . HOH   E 3 .   ? 23.99325  17.47585  26.14579  1.000 31.88575 ? 591 HOH   B O   1 
HETATM 6090 O O   . HOH   E 3 .   ? 17.86681  25.56304  10.84701  1.000 35.47224 ? 592 HOH   B O   1 
HETATM 6091 O O   . HOH   E 3 .   ? 23.92810  17.67432  30.28575  1.000 19.61073 ? 593 HOH   B O   1 
HETATM 6092 O O   . HOH   E 3 .   ? 14.10801  -1.94131  16.41234  1.000 5.90177  ? 594 HOH   B O   1 
HETATM 6093 O O   . HOH   E 3 .   ? 1.80752   -2.12866  37.44517  1.000 10.43817 ? 595 HOH   B O   1 
HETATM 6094 O O   . HOH   E 3 .   ? -23.09534 8.63876   26.49574  1.000 20.98552 ? 596 HOH   B O   1 
HETATM 6095 O O   . HOH   E 3 .   ? 4.74045   -10.69109 34.29598  1.000 16.57871 ? 597 HOH   B O   1 
HETATM 6096 O O   . HOH   E 3 .   ? 8.06977   11.52334  40.23427  1.000 22.25026 ? 598 HOH   B O   1 
HETATM 6097 O O   . HOH   E 3 .   ? -26.07122 8.49161   11.67555  1.000 26.75837 ? 599 HOH   B O   1 
HETATM 6098 O O   . HOH   E 3 .   ? -0.52907  0.39409   21.42027  1.000 12.54038 ? 600 HOH   B O   1 
HETATM 6099 O O   . HOH   E 3 .   ? 7.64357   17.46557  30.47201  1.000 14.03900 ? 601 HOH   B O   1 
HETATM 6100 O O   . HOH   E 3 .   ? 15.85088  -23.71431 40.92933  1.000 27.10158 ? 602 HOH   B O   1 
HETATM 6101 O O   . HOH   E 3 .   ? -3.19708  27.24094  25.43487  1.000 24.15979 ? 603 HOH   B O   1 
HETATM 6102 O O   . HOH   E 3 .   ? -15.88494 1.15046   35.01664  1.000 21.83117 ? 604 HOH   B O   1 
HETATM 6103 O O   . HOH   E 3 .   ? 14.89392  23.71350  26.36471  1.000 33.34885 ? 605 HOH   B O   1 
HETATM 6104 O O   . HOH   E 3 .   ? 10.23396  28.47703  29.72465  1.000 21.57400 ? 606 HOH   B O   1 
HETATM 6105 O O   . HOH   E 3 .   ? -7.32233  1.34718   18.98051  1.000 11.16221 ? 607 HOH   B O   1 
HETATM 6106 O O   . HOH   E 3 .   ? 4.65985   -8.24001  33.00710  1.000 16.00033 ? 608 HOH   B O   1 
HETATM 6107 O O   . HOH   E 3 .   ? 7.51870   -10.05174 20.55038  1.000 26.36047 ? 609 HOH   B O   1 
HETATM 6108 O O   . HOH   E 3 .   ? 14.28252  16.76639  6.72916   1.000 24.66476 ? 610 HOH   B O   1 
HETATM 6109 O O   . HOH   E 3 .   ? 5.73298   11.54964  12.21820  1.000 22.33175 ? 611 HOH   B O   1 
HETATM 6110 O O   . HOH   E 3 .   ? 4.71152   -0.58988  51.63423  1.000 19.87679 ? 612 HOH   B O   1 
HETATM 6111 O O   . HOH   E 3 .   ? -18.96295 24.61357  20.01479  1.000 25.13355 ? 613 HOH   B O   1 
HETATM 6112 O O   . HOH   E 3 .   ? -21.37450 12.09507  24.83214  1.000 23.97678 ? 614 HOH   B O   1 
HETATM 6113 O O   . HOH   E 3 .   ? 18.95256  22.69114  37.14690  1.000 39.39403 ? 615 HOH   B O   1 
HETATM 6114 O O   . HOH   E 3 .   ? -24.85501 21.15839  15.21012  1.000 29.56159 ? 616 HOH   B O   1 
HETATM 6115 O O   . HOH   E 3 .   ? -11.37904 1.53049   40.37934  1.000 16.99361 ? 617 HOH   B O   1 
HETATM 6116 O O   . HOH   E 3 .   ? 15.36261  -1.11927  49.78685  1.000 31.75569 ? 618 HOH   B O   1 
HETATM 6117 O O   . HOH   E 3 .   ? 11.66058  4.71157   22.80358  1.000 29.51492 ? 619 HOH   B O   1 
HETATM 6118 O O   . HOH   E 3 .   ? -11.83049 8.73271   40.27549  1.000 24.82038 ? 620 HOH   B O   1 
HETATM 6119 O O   . HOH   E 3 .   ? 2.23031   9.00130   24.46828  1.000 8.94383  ? 621 HOH   B O   1 
HETATM 6120 O O   . HOH   E 3 .   ? 10.79515  -19.66939 46.07946  1.000 33.81272 ? 622 HOH   B O   1 
HETATM 6121 O O   . HOH   E 3 .   ? 12.41207  25.09295  28.20194  1.000 33.93079 ? 623 HOH   B O   1 
HETATM 6122 O O   . HOH   E 3 .   ? 2.00130   9.16558   27.25660  1.000 12.80606 ? 624 HOH   B O   1 
HETATM 6123 O O   . HOH   E 3 .   ? -14.03400 8.37116   35.41067  1.000 11.69171 ? 625 HOH   B O   1 
HETATM 6124 O O   . HOH   E 3 .   ? 24.331    12.892    27.851    1.000 32.41828 ? 626 HOH   B O   1 
HETATM 6125 O O   . HOH   E 3 .   ? 7.33866   6.93673   16.49212  1.000 10.68765 ? 627 HOH   B O   1 
HETATM 6126 O O   . HOH   E 3 .   ? -1.18415  11.29142  45.33644  1.000 23.17049 ? 628 HOH   B O   1 
HETATM 6127 O O   . HOH   E 3 .   ? -16.64977 2.34765   10.83475  1.000 12.16665 ? 629 HOH   B O   1 
HETATM 6128 O O   . HOH   E 3 .   ? 16.53610  -11.73666 46.32112  1.000 21.86641 ? 630 HOH   B O   1 
HETATM 6129 O O   . HOH   E 3 .   ? -24.026   4.977     28.273    1.000 28.63121 ? 631 HOH   B O   1 
HETATM 6130 O O   . HOH   E 3 .   ? 22.04515  18.90130  23.41509  1.000 17.89458 ? 632 HOH   B O   1 
HETATM 6131 O O   . HOH   E 3 .   ? 1.14546   12.77346  44.66426  1.000 24.91832 ? 633 HOH   B O   1 
HETATM 6132 O O   . HOH   E 3 .   ? -15.61228 6.33645   33.93381  1.000 9.99866  ? 634 HOH   B O   1 
HETATM 6133 O O   . HOH   E 3 .   ? -18.81581 5.85750   31.30788  1.000 16.94800 ? 635 HOH   B O   1 
HETATM 6134 O O   . HOH   E 3 .   ? -24.72402 14.80271  18.03384  1.000 21.18682 ? 636 HOH   B O   1 
HETATM 6135 O O   . HOH   E 3 .   ? -7.14758  -5.30164  19.93161  1.000 24.38982 ? 637 HOH   B O   1 
HETATM 6136 O O   . HOH   E 3 .   ? -10.66725 13.22507  35.43224  1.000 15.88194 ? 638 HOH   B O   1 
HETATM 6137 O O   . HOH   E 3 .   ? 25.08577  10.79283  24.81319  1.000 19.75838 ? 639 HOH   B O   1 
HETATM 6138 O O   . HOH   E 3 .   ? -6.06984  22.31574  9.10252   1.000 16.33932 ? 640 HOH   B O   1 
HETATM 6139 O O   . HOH   E 3 .   ? 9.05222   7.57830   46.00697  1.000 18.61852 ? 641 HOH   B O   1 
HETATM 6140 O O   . HOH   E 3 .   ? 0.83961   6.05441   51.85990  1.000 22.63739 ? 642 HOH   B O   1 
HETATM 6141 O O   . HOH   E 3 .   ? -23.86053 22.26422  20.87555  1.000 28.51469 ? 643 HOH   B O   1 
HETATM 6142 O O   . HOH   E 3 .   ? 15.11278  13.68429  12.47860  1.000 17.12466 ? 644 HOH   B O   1 
HETATM 6143 O O   . HOH   E 3 .   ? 7.70314   22.46533  8.93306   1.000 25.02395 ? 645 HOH   B O   1 
HETATM 6144 O O   . HOH   E 3 .   ? 7.67454   21.28107  33.72634  1.000 20.16978 ? 646 HOH   B O   1 
HETATM 6145 O O   . HOH   E 3 .   ? 4.93381   15.44691  9.90581   1.000 31.57949 ? 647 HOH   B O   1 
HETATM 6146 O O   . HOH   E 3 .   ? -13.31959 2.34385   35.45393  1.000 20.39150 ? 648 HOH   B O   1 
HETATM 6147 O O   . HOH   E 3 .   ? -24.35299 3.49446   16.64969  1.000 14.72361 ? 649 HOH   B O   1 
HETATM 6148 O O   . HOH   E 3 .   ? 18.51012  -12.93508 31.52949  1.000 33.27515 ? 650 HOH   B O   1 
HETATM 6149 O O   . HOH   E 3 .   ? 3.96365   20.43094  8.98051   1.000 31.00610 ? 651 HOH   B O   1 
HETATM 6150 O O   . HOH   E 3 .   ? 4.40449   -8.25618  20.92876  1.000 13.31627 ? 652 HOH   B O   1 
HETATM 6151 O O   . HOH   E 3 .   ? 5.70999   0.78035   17.58519  1.000 20.98305 ? 653 HOH   B O   1 
HETATM 6152 O O   . HOH   E 3 .   ? -16.37714 -13.17815 30.25754  1.000 29.32614 ? 654 HOH   B O   1 
HETATM 6153 O O   . HOH   E 3 .   ? 15.14601  -6.30919  17.00959  1.000 14.89369 ? 655 HOH   B O   1 
HETATM 6154 O O   . HOH   E 3 .   ? 7.37954   9.80850   44.93043  1.000 24.84643 ? 656 HOH   B O   1 
HETATM 6155 O O   . HOH   E 3 .   ? 21.81179  3.46438   31.90219  1.000 44.37603 ? 657 HOH   B O   1 
HETATM 6156 O O   . HOH   E 3 .   ? 22.73599  23.83774  29.69844  1.000 28.48991 ? 658 HOH   B O   1 
HETATM 6157 O O   . HOH   E 3 .   ? -16.71477 -10.02167 35.79287  1.000 32.25645 ? 659 HOH   B O   1 
HETATM 6158 O O   . HOH   E 3 .   ? -10.81023 22.61825  31.66763  1.000 34.49494 ? 660 HOH   B O   1 
HETATM 6159 O O   . HOH   E 3 .   ? 12.80493  0.05775   52.45095  1.000 33.93587 ? 661 HOH   B O   1 
HETATM 6160 O O   . HOH   E 3 .   ? -13.50558 10.53214  2.72545   1.000 18.00208 ? 662 HOH   B O   1 
HETATM 6161 O O   . HOH   E 3 .   ? -11.78604 11.00750  36.50314  1.000 16.92122 ? 663 HOH   B O   1 
HETATM 6162 O O   . HOH   E 3 .   ? 15.89668  -6.21187  33.98673  1.000 20.05048 ? 664 HOH   B O   1 
HETATM 6163 O O   . HOH   E 3 .   ? 19.03699  15.09817  13.05105  1.000 24.65018 ? 665 HOH   B O   1 
HETATM 6164 O O   . HOH   E 3 .   ? 11.55075  7.97047   46.32223  1.000 27.95939 ? 666 HOH   B O   1 
HETATM 6165 O O   . HOH   E 3 .   ? -11.81417 27.78073  20.99009  1.000 22.61704 ? 667 HOH   B O   1 
HETATM 6166 O O   . HOH   E 3 .   ? -6.55935  29.80457  25.51366  1.000 26.69287 ? 668 HOH   B O   1 
HETATM 6167 O O   . HOH   E 3 .   ? 9.33677   -12.89157 28.16810  1.000 29.43483 ? 669 HOH   B O   1 
HETATM 6168 O O   . HOH   E 3 .   ? 8.84360   -17.28439 32.62700  1.000 33.92382 ? 670 HOH   B O   1 
HETATM 6169 O O   . HOH   E 3 .   ? 2.19944   5.78774   48.88850  1.000 17.35819 ? 671 HOH   B O   1 
HETATM 6170 O O   . HOH   E 3 .   ? 3.94493   -13.01873 32.43511  1.000 22.26984 ? 672 HOH   B O   1 
HETATM 6171 O O   . HOH   E 3 .   ? 21.44975  4.47049   16.66436  1.000 22.10672 ? 673 HOH   B O   1 
HETATM 6172 O O   . HOH   E 3 .   ? 9.70787   -6.63108  23.30773  1.000 15.94613 ? 674 HOH   B O   1 
HETATM 6173 O O   . HOH   E 3 .   ? -12.42102 20.36051  5.55872   1.000 11.92446 ? 675 HOH   B O   1 
HETATM 6174 O O   . HOH   E 3 .   ? -13.10779 -16.40679 37.05320  1.000 28.64359 ? 676 HOH   B O   1 
HETATM 6175 O O   . HOH   E 3 .   ? -11.45627 25.33987  24.48704  1.000 26.64699 ? 677 HOH   B O   1 
HETATM 6176 O O   . HOH   E 3 .   ? -8.61078  21.54193  28.65107  1.000 17.82492 ? 678 HOH   B O   1 
HETATM 6177 O O   . HOH   E 3 .   ? -20.09645 -0.98487  33.48781  1.000 27.16708 ? 679 HOH   B O   1 
HETATM 6178 O O   . HOH   E 3 .   ? 20.38457  -11.50384 35.95273  1.000 32.98421 ? 680 HOH   B O   1 
HETATM 6179 O O   . HOH   E 3 .   ? 10.55514  -9.22829  23.74596  1.000 21.36659 ? 681 HOH   B O   1 
HETATM 6180 O O   . HOH   E 3 .   ? -18.50233 5.61465   39.39097  1.000 35.37696 ? 682 HOH   B O   1 
HETATM 6181 O O   . HOH   E 3 .   ? 16.12192  24.54761  30.35531  1.000 31.52997 ? 683 HOH   B O   1 
HETATM 6182 O O   . HOH   E 3 .   ? 19.67172  14.78896  34.33775  1.000 21.85954 ? 684 HOH   B O   1 
HETATM 6183 O O   . HOH   E 3 .   ? 18.83898  15.10508  36.82004  1.000 37.58148 ? 685 HOH   B O   1 
HETATM 6184 O O   . HOH   E 3 .   ? -9.32651  -0.16144  20.41406  1.000 14.24428 ? 686 HOH   B O   1 
HETATM 6185 O O   . HOH   E 3 .   ? 17.89331  22.92613  25.57077  1.000 33.00002 ? 687 HOH   B O   1 
HETATM 6186 O O   . HOH   E 3 .   ? -15.75333 25.64060  23.38461  1.000 30.42623 ? 688 HOH   B O   1 
HETATM 6187 O O   . HOH   E 3 .   ? 20.79063  -18.34448 41.60084  1.000 27.56350 ? 689 HOH   B O   1 
HETATM 6188 O O   . HOH   E 3 .   ? 24.24150  5.09841   31.05143  1.000 40.00358 ? 690 HOH   B O   1 
HETATM 6189 O O   . HOH   E 3 .   ? -9.968    -5.636    45.146    1.000 35.28707 ? 691 HOH   B O   1 
HETATM 6190 O O   . HOH   E 3 .   ? 9.49175   -14.67188 31.80836  1.000 25.21642 ? 692 HOH   B O   1 
HETATM 6191 O O   . HOH   E 3 .   ? -11.11738 16.19471  32.73118  1.000 12.13901 ? 693 HOH   B O   1 
HETATM 6192 O O   . HOH   E 3 .   ? -14.82245 -4.22415  36.69633  1.000 25.65652 ? 694 HOH   B O   1 
HETATM 6193 O O   . HOH   E 3 .   ? 0.51176   22.09882  36.14054  1.000 29.48801 ? 695 HOH   B O   1 
HETATM 6194 O O   . HOH   E 3 .   ? 5.90612   13.94151  45.40900  1.000 38.81159 ? 696 HOH   B O   1 
HETATM 6195 O O   . HOH   E 3 .   ? 19.18091  -3.89997  21.49214  1.000 25.63372 ? 697 HOH   B O   1 
HETATM 6196 O O   . HOH   E 3 .   ? -12.92802 18.20594  31.81671  1.000 15.82356 ? 698 HOH   B O   1 
HETATM 6197 O O   . HOH   E 3 .   ? -6.00157  30.64191  11.68865  1.000 42.90145 ? 699 HOH   B O   1 
HETATM 6198 O O   . HOH   E 3 .   ? 17.22983  16.85422  38.25630  1.000 32.97078 ? 700 HOH   B O   1 
HETATM 6199 O O   . HOH   E 3 .   ? 12.69318  -12.97102 28.49087  1.000 34.70173 ? 701 HOH   B O   1 
HETATM 6200 O O   . HOH   E 3 .   ? 7.27490   1.18695   28.41161  1.000 34.95762 ? 702 HOH   B O   1 
HETATM 6201 O O   . HOH   E 3 .   ? 12.68550  -11.24389 52.24741  1.000 27.18160 ? 703 HOH   B O   1 
HETATM 6202 O O   . HOH   E 3 .   ? 16.50632  -7.41052  31.68692  1.000 21.67470 ? 704 HOH   B O   1 
HETATM 6203 O O   . HOH   E 3 .   ? 20.98319  18.82384  32.37574  1.000 27.52353 ? 705 HOH   B O   1 
HETATM 6204 O O   . HOH   E 3 .   ? 14.42309  -3.65858  33.99911  1.000 25.10941 ? 706 HOH   B O   1 
HETATM 6205 O O   . HOH   E 3 .   ? -8.60207  25.98976  29.76351  1.000 38.47870 ? 707 HOH   B O   1 
HETATM 6206 O O   . HOH   E 3 .   ? -8.69139  33.84143  16.97159  1.000 23.19192 ? 708 HOH   B O   1 
HETATM 6207 O O   . HOH   E 3 .   ? 0.35341   28.73166  35.75648  1.000 37.77215 ? 709 HOH   B O   1 
HETATM 6208 O O   . HOH   E 3 .   ? 8.74129   -13.15088 51.79610  1.000 20.65079 ? 710 HOH   B O   1 
HETATM 6209 O O   . HOH   E 3 .   ? -18.84406 12.27779  31.30586  1.000 18.61660 ? 711 HOH   B O   1 
HETATM 6210 O O   . HOH   E 3 .   ? 14.26428  7.03790   45.70825  1.000 36.37660 ? 712 HOH   B O   1 
HETATM 6211 O O   . HOH   E 3 .   ? 5.81030   21.61323  41.32088  1.000 33.55541 ? 713 HOH   B O   1 
HETATM 6212 O O   . HOH   E 3 .   ? 19.58782  17.89475  13.23531  1.000 31.25015 ? 714 HOH   B O   1 
HETATM 6213 O O   . HOH   E 3 .   ? -10.91080 29.88067  11.90898  1.000 40.42062 ? 715 HOH   B O   1 
HETATM 6214 O O   . HOH   E 3 .   ? 10.82776  -5.41964  52.83747  1.000 38.91531 ? 716 HOH   B O   1 
HETATM 6215 O O   . HOH   E 3 .   ? -10.96925 -9.15182  23.38593  1.000 22.62354 ? 717 HOH   B O   1 
HETATM 6216 O O   . HOH   E 3 .   ? 4.93018   16.38553  6.69049   1.000 30.32700 ? 718 HOH   B O   1 
HETATM 6217 O O   . HOH   E 3 .   ? -6.04045  11.56304  43.52346  1.000 28.43432 ? 719 HOH   B O   1 
HETATM 6218 O O   . HOH   E 3 .   ? 7.45752   -13.41391 23.21767  1.000 30.25710 ? 720 HOH   B O   1 
HETATM 6219 O O   . HOH   E 3 .   ? -14.61473 11.84302  36.03082  1.000 21.81892 ? 721 HOH   B O   1 
HETATM 6220 O O   . HOH   E 3 .   ? 17.37290  -15.57117 30.98811  1.000 33.09703 ? 722 HOH   B O   1 
HETATM 6221 O O   . HOH   E 3 .   ? 13.43970  -20.88557 45.24633  1.000 27.31636 ? 723 HOH   B O   1 
HETATM 6222 O O   . HOH   E 3 .   ? -22.86573 22.92615  18.41821  1.000 34.93529 ? 724 HOH   B O   1 
HETATM 6223 O O   . HOH   E 3 .   ? 12.27320  -15.06043 30.60484  1.000 26.05529 ? 725 HOH   B O   1 
HETATM 6224 O O   . HOH   E 3 .   ? 3.30384   -9.72091  53.71773  1.000 30.36982 ? 726 HOH   B O   1 
HETATM 6225 O O   . HOH   E 3 .   ? 12.88414  -17.92645 31.29156  1.000 38.82835 ? 727 HOH   B O   1 
HETATM 6226 O O   . HOH   E 3 .   ? 18.53515  26.01159  13.44583  1.000 33.09636 ? 728 HOH   B O   1 
HETATM 6227 O O   . HOH   E 3 .   ? 19.62324  -8.15785  15.01966  1.000 24.98293 ? 729 HOH   B O   1 
HETATM 6228 O O   . HOH   E 3 .   ? -19.21028 16.97027  10.67455  1.000 33.39207 ? 730 HOH   B O   1 
HETATM 6229 O O   . HOH   E 3 .   ? -11.76670 -15.67996 41.25616  1.000 40.00880 ? 731 HOH   B O   1 
HETATM 6230 O O   . HOH   E 3 .   ? 8.645     12.927    41.935    1.000 22.84290 ? 732 HOH   B O   1 
HETATM 6231 O O   . HOH   E 3 .   ? 10.22501  1.27001   52.33554  1.000 32.58344 ? 733 HOH   B O   1 
HETATM 6232 O O   . HOH   E 3 .   ? 19.68317  -7.81490  31.55705  1.000 25.96699 ? 734 HOH   B O   1 
HETATM 6233 O O   . HOH   E 3 .   ? -13.57382 -14.68879 43.18915  1.000 39.70418 ? 735 HOH   B O   1 
HETATM 6234 O O   . HOH   E 3 .   ? 13.53674  1.40919   49.80151  1.000 24.07877 ? 736 HOH   B O   1 
HETATM 6235 O O   . HOH   E 3 .   ? 15.70623  7.42337   43.79276  1.000 27.06395 ? 737 HOH   B O   1 
HETATM 6236 O O   . HOH   E 3 .   ? -18.84753 22.03476  16.15130  1.000 16.26754 ? 738 HOH   B O   1 
HETATM 6237 O O   . HOH   E 3 .   ? -21.32747 25.41409  18.31671  1.000 38.20094 ? 739 HOH   B O   1 
HETATM 6238 O O   . HOH   E 3 .   ? 19.24415  -5.13626  39.86636  1.000 26.77260 ? 740 HOH   B O   1 
HETATM 6239 O O   . HOH   E 3 .   ? 1.17666   21.46055  8.76705   1.000 40.84216 ? 741 HOH   B O   1 
HETATM 6240 O O   . HOH   E 3 .   ? -27.37622 6.87591   9.26662   1.000 24.21411 ? 742 HOH   B O   1 
HETATM 6241 O O   . HOH   E 3 .   ? 8.55121   13.39772  8.86761   1.000 29.87548 ? 743 HOH   B O   1 
HETATM 6242 O O   . HOH   E 3 .   ? 19.03229  -7.15632  37.51561  1.000 25.74434 ? 744 HOH   B O   1 
HETATM 6243 O O   . HOH   E 3 .   ? -21.69292 21.35872  10.01824  1.000 41.05728 ? 745 HOH   B O   1 
HETATM 6244 O O   . HOH   E 3 .   ? -5.42783  -11.81677 32.61538  1.000 34.79461 ? 746 HOH   B O   1 
HETATM 6245 O O   . HOH   E 3 .   ? 17.04191  11.85103  11.20437  1.000 33.65101 ? 747 HOH   B O   1 
HETATM 6246 O O   . HOH   E 3 .   ? 7.78161   -19.90492 31.61851  1.000 33.40855 ? 748 HOH   B O   1 
HETATM 6247 O O   . HOH   E 3 .   ? 1.17609   19.36389  37.38469  1.000 21.91376 ? 749 HOH   B O   1 
HETATM 6248 O O   . HOH   E 3 .   ? -5.69696  26.87748  26.06469  1.000 25.45657 ? 750 HOH   B O   1 
HETATM 6249 O O   . HOH   E 3 .   ? -16.47969 12.91937  5.92180   1.000 35.32065 ? 751 HOH   B O   1 
HETATM 6250 O O   . HOH   E 3 .   ? 1.75294   -20.17614 40.24331  1.000 30.00436 ? 752 HOH   B O   1 
HETATM 6251 O O   . HOH   E 3 .   ? -17.46674 10.44207  5.06248   1.000 21.29190 ? 753 HOH   B O   1 
HETATM 6252 O O   . HOH   E 3 .   ? -14.82940 17.79991  35.65309  1.000 36.04253 ? 754 HOH   B O   1 
HETATM 6253 O O   . HOH   E 3 .   ? -19.41388 23.74859  14.31109  1.000 29.00425 ? 755 HOH   B O   1 
HETATM 6254 O O   . HOH   E 3 .   ? -9.62861  19.86083  35.07636  1.000 40.72219 ? 756 HOH   B O   1 
HETATM 6255 O O   . HOH   E 3 .   ? -18.15010 24.25882  17.24025  1.000 19.48374 ? 757 HOH   B O   1 
HETATM 6256 O O   . HOH   E 3 .   ? -14.17508 29.35579  20.55939  1.000 22.31912 ? 758 HOH   B O   1 
HETATM 6257 O O   . HOH   E 3 .   ? -11.36993 30.24983  7.51327   1.000 31.61570 ? 759 HOH   B O   1 
HETATM 6258 O O   . HOH   E 3 .   ? -21.59743 3.11797   34.03192  1.000 40.93046 ? 760 HOH   B O   1 
HETATM 6259 O O   . HOH   E 3 .   ? -10.36455 15.59563  37.34065  1.000 39.11399 ? 761 HOH   B O   1 
HETATM 6260 O O   . HOH   E 3 .   ? 18.15379  -5.44183  35.30828  1.000 26.63062 ? 762 HOH   B O   1 
HETATM 6261 O O   . HOH   E 3 .   ? -6.91112  -8.89984  20.02580  1.000 22.81735 ? 763 HOH   B O   1 
HETATM 6262 O O   . HOH   E 3 .   ? 10.49949  11.47361  39.01104  1.000 27.46869 ? 764 HOH   B O   1 
HETATM 6263 O O   . HOH   E 3 .   ? -12.11686 31.49758  9.78860   1.000 37.06540 ? 765 HOH   B O   1 
HETATM 6264 O O   . HOH   E 3 .   ? 8.91319   16.82866  6.77132   1.000 35.43757 ? 766 HOH   B O   1 
HETATM 6265 O O   . HOH   E 3 .   ? -24.22252 15.14256  34.03646  1.000 41.12845 ? 767 HOH   B O   1 
HETATM 6266 O O   . HOH   E 3 .   ? -4.48894  8.34811   48.31869  1.000 37.02337 ? 768 HOH   B O   1 
HETATM 6267 O O   . HOH   E 3 .   ? 20.21841  -6.17385  33.53383  1.000 38.70066 ? 769 HOH   B O   1 
HETATM 6268 O O   . HOH   E 3 .   ? -13.30488 25.95544  22.50798  1.000 22.66542 ? 770 HOH   B O   1 
HETATM 6269 O O   . HOH   E 3 .   ? -10.74007 29.21055  22.98527  1.000 28.07212 ? 771 HOH   B O   1 
HETATM 6270 O O   . HOH   E 3 .   ? -0.41073  21.82332  39.67922  1.000 37.93734 ? 772 HOH   B O   1 
HETATM 6271 O O   . HOH   E 3 .   ? -6.70582  11.58975  46.30684  1.000 33.35908 ? 773 HOH   B O   1 
HETATM 6272 O O   . HOH   E 3 .   ? -25.19469 16.18165  36.13075  1.000 33.21590 ? 774 HOH   B O   1 
# 
