data_8YSN
# 
_entry.id   8YSN 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YSN         pdb_00008ysn 10.2210/pdb8ysn/pdb 
WWPDB D_1300046308 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YSN 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chyeah6599@nchu.edu.tw 
_pdbx_contact_author.name_first         Yeh 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7740-0446 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, Y.-C.' 1 ? 
'Yang, C.-S.' 2 ? 
'Hou, M.-H.'  3 ? 
'Chen, Y.'    4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            295 
_citation.language                  ? 
_citation.page_first                139534 
_citation.page_last                 139534 
_citation.title                     
'Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.139534 
_citation.pdbx_database_id_PubMed   39761885 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, C.S.'  1 ? 
primary 'Shie, M.Y.'  2 ? 
primary 'Huang, S.W.' 3 ? 
primary 'Wang, Y.C.'  4 ? 
primary 'Hou, M.H.'   5 ? 
primary 'Chen, C.J.'  6 ? 
primary 'Chen, Y.'    7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleotidyltransferase 37251.785 1   ? ? ? ? 
2 non-polymer syn 'PHOSPHATE ION'        94.971    1   ? ? ? ? 
3 water       nat water                  18.015    199 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKGSGYDDRDALEQFVQTM
LDNFHDGSGPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADHFGSEFPVPEKDKSA
VHTAPAIVGSGSSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKGSGYDDRDALEQFVQTM
LDNFHDGSGPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADHFGSEFPVPEKDKSA
VHTAPAIVGSGSSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PHOSPHATE ION' PO4 
3 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PRO n 
1 4   VAL n 
1 5   GLN n 
1 6   LYS n 
1 7   GLN n 
1 8   PHE n 
1 9   ARG n 
1 10  GLU n 
1 11  PHE n 
1 12  HIS n 
1 13  ASP n 
1 14  ARG n 
1 15  ILE n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLN n 
1 20  TYR n 
1 21  ASP n 
1 22  GLU n 
1 23  ASN n 
1 24  GLN n 
1 25  THR n 
1 26  LEU n 
1 27  ARG n 
1 28  ASP n 
1 29  GLU n 
1 30  ARG n 
1 31  ASP n 
1 32  ALA n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  ALA n 
1 37  VAL n 
1 38  ARG n 
1 39  GLU n 
1 40  GLY n 
1 41  LEU n 
1 42  LYS n 
1 43  LYS n 
1 44  VAL n 
1 45  PHE n 
1 46  ALA n 
1 47  ASP n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  ALA n 
1 52  ALA n 
1 53  PRO n 
1 54  THR n 
1 55  PHE n 
1 56  THR n 
1 57  PRO n 
1 58  PHE n 
1 59  ASN n 
1 60  GLN n 
1 61  GLY n 
1 62  SER n 
1 63  TYR n 
1 64  ALA n 
1 65  MET n 
1 66  ASN n 
1 67  THR n 
1 68  GLY n 
1 69  VAL n 
1 70  LYS n 
1 71  PRO n 
1 72  LEU n 
1 73  GLU n 
1 74  GLY n 
1 75  GLY n 
1 76  GLU n 
1 77  TYR n 
1 78  ASP n 
1 79  ILE n 
1 80  ASP n 
1 81  VAL n 
1 82  GLY n 
1 83  ILE n 
1 84  ILE n 
1 85  LEU n 
1 86  ASN n 
1 87  ILE n 
1 88  ALA n 
1 89  LYS n 
1 90  ASP n 
1 91  ASP n 
1 92  HIS n 
1 93  ASP n 
1 94  PRO n 
1 95  VAL n 
1 96  GLU n 
1 97  VAL n 
1 98  LYS n 
1 99  LYS n 
1 100 TRP n 
1 101 ILE n 
1 102 ARG n 
1 103 ASP n 
1 104 ALA n 
1 105 LEU n 
1 106 LYS n 
1 107 ASP n 
1 108 TYR n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 ALA n 
1 113 GLU n 
1 114 ILE n 
1 115 ARG n 
1 116 ARG n 
1 117 SER n 
1 118 CYS n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 PHE n 
1 123 LYS n 
1 124 PRO n 
1 125 GLY n 
1 126 TYR n 
1 127 HIS n 
1 128 VAL n 
1 129 ASP n 
1 130 LEU n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 ALA n 
1 135 ASP n 
1 136 PRO n 
1 137 GLU n 
1 138 LEU n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 LEU n 
1 144 CYS n 
1 145 ILE n 
1 146 ALA n 
1 147 LYS n 
1 148 GLY n 
1 149 LYS n 
1 150 GLU n 
1 151 ASN n 
1 152 SER n 
1 153 GLY n 
1 154 ASP n 
1 155 GLU n 
1 156 HIS n 
1 157 ARG n 
1 158 LEU n 
1 159 TRP n 
1 160 GLN n 
1 161 ILE n 
1 162 SER n 
1 163 ASP n 
1 164 PRO n 
1 165 GLN n 
1 166 GLY n 
1 167 PHE n 
1 168 GLN n 
1 169 ASP n 
1 170 ARG n 
1 171 ILE n 
1 172 ALA n 
1 173 SER n 
1 174 LYS n 
1 175 LEU n 
1 176 SER n 
1 177 GLY n 
1 178 ASP n 
1 179 ASP n 
1 180 ALA n 
1 181 ALA n 
1 182 GLN n 
1 183 PHE n 
1 184 ARG n 
1 185 ARG n 
1 186 CYS n 
1 187 ILE n 
1 188 ARG n 
1 189 TYR n 
1 190 LEU n 
1 191 LYS n 
1 192 ARG n 
1 193 TRP n 
1 194 ARG n 
1 195 ASP n 
1 196 PHE n 
1 197 ARG n 
1 198 PHE n 
1 199 SER n 
1 200 SER n 
1 201 ASP n 
1 202 GLY n 
1 203 ASN n 
1 204 ALA n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 LEU n 
1 212 THR n 
1 213 ALA n 
1 214 ALA n 
1 215 ALA n 
1 216 TYR n 
1 217 TRP n 
1 218 TRP n 
1 219 PHE n 
1 220 GLN n 
1 221 VAL n 
1 222 SER n 
1 223 LYS n 
1 224 GLY n 
1 225 SER n 
1 226 GLY n 
1 227 TYR n 
1 228 ASP n 
1 229 ASP n 
1 230 ARG n 
1 231 ASP n 
1 232 ALA n 
1 233 LEU n 
1 234 GLU n 
1 235 GLN n 
1 236 PHE n 
1 237 VAL n 
1 238 GLN n 
1 239 THR n 
1 240 MET n 
1 241 LEU n 
1 242 ASP n 
1 243 ASN n 
1 244 PHE n 
1 245 HIS n 
1 246 ASP n 
1 247 GLY n 
1 248 SER n 
1 249 GLY n 
1 250 PRO n 
1 251 ARG n 
1 252 LEU n 
1 253 THR n 
1 254 VAL n 
1 255 GLU n 
1 256 LEU n 
1 257 PRO n 
1 258 VAL n 
1 259 GLN n 
1 260 PRO n 
1 261 TYR n 
1 262 ASN n 
1 263 ASP n 
1 264 VAL n 
1 265 PHE n 
1 266 GLU n 
1 267 LYS n 
1 268 MET n 
1 269 THR n 
1 270 GLY n 
1 271 MET n 
1 272 GLN n 
1 273 MET n 
1 274 GLU n 
1 275 SER n 
1 276 PHE n 
1 277 LYS n 
1 278 SER n 
1 279 LYS n 
1 280 LEU n 
1 281 GLN n 
1 282 ALA n 
1 283 LEU n 
1 284 LEU n 
1 285 ASN n 
1 286 ALA n 
1 287 LEU n 
1 288 LYS n 
1 289 THR n 
1 290 ALA n 
1 291 LYS n 
1 292 SER n 
1 293 ARG n 
1 294 LEU n 
1 295 GLU n 
1 296 LEU n 
1 297 HIS n 
1 298 ASP n 
1 299 ALA n 
1 300 CYS n 
1 301 LYS n 
1 302 ALA n 
1 303 LEU n 
1 304 ALA n 
1 305 ASP n 
1 306 HIS n 
1 307 PHE n 
1 308 GLY n 
1 309 SER n 
1 310 GLU n 
1 311 PHE n 
1 312 PRO n 
1 313 VAL n 
1 314 PRO n 
1 315 GLU n 
1 316 LYS n 
1 317 ASP n 
1 318 LYS n 
1 319 SER n 
1 320 ALA n 
1 321 VAL n 
1 322 HIS n 
1 323 THR n 
1 324 ALA n 
1 325 PRO n 
1 326 ALA n 
1 327 ILE n 
1 328 VAL n 
1 329 GLY n 
1 330 SER n 
1 331 GLY n 
1 332 SER n 
1 333 SER n 
1 334 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   334 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 DVJ83_15700 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Deinococcus wulumuqiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     980427 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION' ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PRO 3   3   3   PRO PRO A . n 
A 1 4   VAL 4   4   4   VAL VAL A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ALA 18  18  18  ALA ALA A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ASP 28  28  28  ASP ASP A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  ARG 30  30  30  ARG ARG A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  THR 35  35  35  THR THR A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  PRO 53  53  53  PRO PRO A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  TYR 63  63  63  TYR TYR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  MET 65  65  65  MET MET A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 CYS 118 118 118 CYS CYS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 HIS 127 127 127 HIS HIS A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 GLY 141 141 141 GLY GLY A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 ASP 154 154 154 ASP ASP A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 HIS 156 156 156 HIS HIS A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 PRO 164 164 164 PRO PRO A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLN 168 168 168 GLN GLN A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 CYS 186 186 186 CYS CYS A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 VAL 221 221 221 VAL VAL A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 GLY 224 224 224 GLY GLY A . n 
A 1 225 SER 225 225 225 SER SER A . n 
A 1 226 GLY 226 226 226 GLY GLY A . n 
A 1 227 TYR 227 227 227 TYR TYR A . n 
A 1 228 ASP 228 228 228 ASP ASP A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 ARG 230 230 230 ARG ARG A . n 
A 1 231 ASP 231 231 231 ASP ASP A . n 
A 1 232 ALA 232 232 232 ALA ALA A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 GLU 234 234 234 GLU GLU A . n 
A 1 235 GLN 235 235 235 GLN GLN A . n 
A 1 236 PHE 236 236 236 PHE PHE A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 GLN 238 238 238 GLN GLN A . n 
A 1 239 THR 239 239 239 THR THR A . n 
A 1 240 MET 240 240 240 MET MET A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 ASP 242 242 242 ASP ASP A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 PHE 244 244 244 PHE PHE A . n 
A 1 245 HIS 245 245 245 HIS HIS A . n 
A 1 246 ASP 246 246 246 ASP ASP A . n 
A 1 247 GLY 247 247 247 GLY GLY A . n 
A 1 248 SER 248 248 248 SER SER A . n 
A 1 249 GLY 249 249 249 GLY GLY A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 ARG 251 251 251 ARG ARG A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 THR 253 253 253 THR THR A . n 
A 1 254 VAL 254 254 254 VAL VAL A . n 
A 1 255 GLU 255 255 255 GLU GLU A . n 
A 1 256 LEU 256 256 256 LEU LEU A . n 
A 1 257 PRO 257 257 257 PRO PRO A . n 
A 1 258 VAL 258 258 258 VAL VAL A . n 
A 1 259 GLN 259 259 259 GLN GLN A . n 
A 1 260 PRO 260 260 260 PRO PRO A . n 
A 1 261 TYR 261 261 261 TYR TYR A . n 
A 1 262 ASN 262 262 262 ASN ASN A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 PHE 265 265 265 PHE PHE A . n 
A 1 266 GLU 266 266 266 GLU GLU A . n 
A 1 267 LYS 267 267 267 LYS LYS A . n 
A 1 268 MET 268 268 268 MET MET A . n 
A 1 269 THR 269 269 269 THR THR A . n 
A 1 270 GLY 270 270 270 GLY GLY A . n 
A 1 271 MET 271 271 271 MET MET A . n 
A 1 272 GLN 272 272 272 GLN GLN A . n 
A 1 273 MET 273 273 273 MET MET A . n 
A 1 274 GLU 274 274 274 GLU GLU A . n 
A 1 275 SER 275 275 275 SER SER A . n 
A 1 276 PHE 276 276 276 PHE PHE A . n 
A 1 277 LYS 277 277 277 LYS LYS A . n 
A 1 278 SER 278 278 278 SER SER A . n 
A 1 279 LYS 279 279 279 LYS LYS A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 GLN 281 281 281 GLN GLN A . n 
A 1 282 ALA 282 282 282 ALA ALA A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 ASN 285 285 285 ASN ASN A . n 
A 1 286 ALA 286 286 286 ALA ALA A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 LYS 288 288 288 LYS LYS A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 ALA 290 290 290 ALA ALA A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 GLU 295 295 295 GLU GLU A . n 
A 1 296 LEU 296 296 296 LEU LEU A . n 
A 1 297 HIS 297 297 297 HIS HIS A . n 
A 1 298 ASP 298 298 298 ASP ASP A . n 
A 1 299 ALA 299 299 299 ALA ALA A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 ALA 302 302 302 ALA ALA A . n 
A 1 303 LEU 303 303 303 LEU LEU A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 ASP 305 305 305 ASP ASP A . n 
A 1 306 HIS 306 306 306 HIS HIS A . n 
A 1 307 PHE 307 307 307 PHE PHE A . n 
A 1 308 GLY 308 308 308 GLY GLY A . n 
A 1 309 SER 309 309 309 SER SER A . n 
A 1 310 GLU 310 310 310 GLU GLU A . n 
A 1 311 PHE 311 311 311 PHE PHE A . n 
A 1 312 PRO 312 312 312 PRO PRO A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 PRO 314 314 314 PRO PRO A . n 
A 1 315 GLU 315 315 315 GLU GLU A . n 
A 1 316 LYS 316 316 316 LYS LYS A . n 
A 1 317 ASP 317 317 ?   ?   ?   A . n 
A 1 318 LYS 318 318 ?   ?   ?   A . n 
A 1 319 SER 319 319 ?   ?   ?   A . n 
A 1 320 ALA 320 320 ?   ?   ?   A . n 
A 1 321 VAL 321 321 ?   ?   ?   A . n 
A 1 322 HIS 322 322 ?   ?   ?   A . n 
A 1 323 THR 323 323 ?   ?   ?   A . n 
A 1 324 ALA 324 324 ?   ?   ?   A . n 
A 1 325 PRO 325 325 ?   ?   ?   A . n 
A 1 326 ALA 326 326 ?   ?   ?   A . n 
A 1 327 ILE 327 327 ?   ?   ?   A . n 
A 1 328 VAL 328 328 ?   ?   ?   A . n 
A 1 329 GLY 329 329 ?   ?   ?   A . n 
A 1 330 SER 330 330 ?   ?   ?   A . n 
A 1 331 GLY 331 331 ?   ?   ?   A . n 
A 1 332 SER 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 GLY 334 334 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 PO4 1   400 400 PO4 PO4 A . 
C 3 HOH 1   501 654 HOH HOH A . 
C 3 HOH 2   502 657 HOH HOH A . 
C 3 HOH 3   503 590 HOH HOH A . 
C 3 HOH 4   504 643 HOH HOH A . 
C 3 HOH 5   505 632 HOH HOH A . 
C 3 HOH 6   506 633 HOH HOH A . 
C 3 HOH 7   507 554 HOH HOH A . 
C 3 HOH 8   508 627 HOH HOH A . 
C 3 HOH 9   509 579 HOH HOH A . 
C 3 HOH 10  510 686 HOH HOH A . 
C 3 HOH 11  511 592 HOH HOH A . 
C 3 HOH 12  512 609 HOH HOH A . 
C 3 HOH 13  513 645 HOH HOH A . 
C 3 HOH 14  514 567 HOH HOH A . 
C 3 HOH 15  515 529 HOH HOH A . 
C 3 HOH 16  516 596 HOH HOH A . 
C 3 HOH 17  517 646 HOH HOH A . 
C 3 HOH 18  518 693 HOH HOH A . 
C 3 HOH 19  519 557 HOH HOH A . 
C 3 HOH 20  520 531 HOH HOH A . 
C 3 HOH 21  521 581 HOH HOH A . 
C 3 HOH 22  522 649 HOH HOH A . 
C 3 HOH 23  523 578 HOH HOH A . 
C 3 HOH 24  524 669 HOH HOH A . 
C 3 HOH 25  525 662 HOH HOH A . 
C 3 HOH 26  526 593 HOH HOH A . 
C 3 HOH 27  527 550 HOH HOH A . 
C 3 HOH 28  528 631 HOH HOH A . 
C 3 HOH 29  529 566 HOH HOH A . 
C 3 HOH 30  530 629 HOH HOH A . 
C 3 HOH 31  531 505 HOH HOH A . 
C 3 HOH 32  532 514 HOH HOH A . 
C 3 HOH 33  533 659 HOH HOH A . 
C 3 HOH 34  534 655 HOH HOH A . 
C 3 HOH 35  535 521 HOH HOH A . 
C 3 HOH 36  536 501 HOH HOH A . 
C 3 HOH 37  537 534 HOH HOH A . 
C 3 HOH 38  538 539 HOH HOH A . 
C 3 HOH 39  539 516 HOH HOH A . 
C 3 HOH 40  540 535 HOH HOH A . 
C 3 HOH 41  541 648 HOH HOH A . 
C 3 HOH 42  542 508 HOH HOH A . 
C 3 HOH 43  543 600 HOH HOH A . 
C 3 HOH 44  544 585 HOH HOH A . 
C 3 HOH 45  545 561 HOH HOH A . 
C 3 HOH 46  546 552 HOH HOH A . 
C 3 HOH 47  547 630 HOH HOH A . 
C 3 HOH 48  548 635 HOH HOH A . 
C 3 HOH 49  549 583 HOH HOH A . 
C 3 HOH 50  550 595 HOH HOH A . 
C 3 HOH 51  551 624 HOH HOH A . 
C 3 HOH 52  552 612 HOH HOH A . 
C 3 HOH 53  553 576 HOH HOH A . 
C 3 HOH 54  554 555 HOH HOH A . 
C 3 HOH 55  555 642 HOH HOH A . 
C 3 HOH 56  556 544 HOH HOH A . 
C 3 HOH 57  557 525 HOH HOH A . 
C 3 HOH 58  558 664 HOH HOH A . 
C 3 HOH 59  559 626 HOH HOH A . 
C 3 HOH 60  560 621 HOH HOH A . 
C 3 HOH 61  561 698 HOH HOH A . 
C 3 HOH 62  562 512 HOH HOH A . 
C 3 HOH 63  563 589 HOH HOH A . 
C 3 HOH 64  564 652 HOH HOH A . 
C 3 HOH 65  565 603 HOH HOH A . 
C 3 HOH 66  566 608 HOH HOH A . 
C 3 HOH 67  567 604 HOH HOH A . 
C 3 HOH 68  568 545 HOH HOH A . 
C 3 HOH 69  569 670 HOH HOH A . 
C 3 HOH 70  570 549 HOH HOH A . 
C 3 HOH 71  571 683 HOH HOH A . 
C 3 HOH 72  572 607 HOH HOH A . 
C 3 HOH 73  573 519 HOH HOH A . 
C 3 HOH 74  574 594 HOH HOH A . 
C 3 HOH 75  575 676 HOH HOH A . 
C 3 HOH 76  576 553 HOH HOH A . 
C 3 HOH 77  577 684 HOH HOH A . 
C 3 HOH 78  578 546 HOH HOH A . 
C 3 HOH 79  579 527 HOH HOH A . 
C 3 HOH 80  580 506 HOH HOH A . 
C 3 HOH 81  581 562 HOH HOH A . 
C 3 HOH 82  582 622 HOH HOH A . 
C 3 HOH 83  583 528 HOH HOH A . 
C 3 HOH 84  584 518 HOH HOH A . 
C 3 HOH 85  585 540 HOH HOH A . 
C 3 HOH 86  586 588 HOH HOH A . 
C 3 HOH 87  587 674 HOH HOH A . 
C 3 HOH 88  588 575 HOH HOH A . 
C 3 HOH 89  589 628 HOH HOH A . 
C 3 HOH 90  590 666 HOH HOH A . 
C 3 HOH 91  591 558 HOH HOH A . 
C 3 HOH 92  592 653 HOH HOH A . 
C 3 HOH 93  593 500 HOH HOH A . 
C 3 HOH 94  594 507 HOH HOH A . 
C 3 HOH 95  595 548 HOH HOH A . 
C 3 HOH 96  596 509 HOH HOH A . 
C 3 HOH 97  597 634 HOH HOH A . 
C 3 HOH 98  598 680 HOH HOH A . 
C 3 HOH 99  599 663 HOH HOH A . 
C 3 HOH 100 600 517 HOH HOH A . 
C 3 HOH 101 601 570 HOH HOH A . 
C 3 HOH 102 602 656 HOH HOH A . 
C 3 HOH 103 603 556 HOH HOH A . 
C 3 HOH 104 604 582 HOH HOH A . 
C 3 HOH 105 605 572 HOH HOH A . 
C 3 HOH 106 606 675 HOH HOH A . 
C 3 HOH 107 607 580 HOH HOH A . 
C 3 HOH 108 608 541 HOH HOH A . 
C 3 HOH 109 609 543 HOH HOH A . 
C 3 HOH 110 610 619 HOH HOH A . 
C 3 HOH 111 611 599 HOH HOH A . 
C 3 HOH 112 612 559 HOH HOH A . 
C 3 HOH 113 613 547 HOH HOH A . 
C 3 HOH 114 614 513 HOH HOH A . 
C 3 HOH 115 615 574 HOH HOH A . 
C 3 HOH 116 616 573 HOH HOH A . 
C 3 HOH 117 617 605 HOH HOH A . 
C 3 HOH 118 618 569 HOH HOH A . 
C 3 HOH 119 619 618 HOH HOH A . 
C 3 HOH 120 620 640 HOH HOH A . 
C 3 HOH 121 621 560 HOH HOH A . 
C 3 HOH 122 622 536 HOH HOH A . 
C 3 HOH 123 623 671 HOH HOH A . 
C 3 HOH 124 624 587 HOH HOH A . 
C 3 HOH 125 625 520 HOH HOH A . 
C 3 HOH 126 626 551 HOH HOH A . 
C 3 HOH 127 627 682 HOH HOH A . 
C 3 HOH 128 628 564 HOH HOH A . 
C 3 HOH 129 629 530 HOH HOH A . 
C 3 HOH 130 630 598 HOH HOH A . 
C 3 HOH 131 631 537 HOH HOH A . 
C 3 HOH 132 632 533 HOH HOH A . 
C 3 HOH 133 633 511 HOH HOH A . 
C 3 HOH 134 634 524 HOH HOH A . 
C 3 HOH 135 635 526 HOH HOH A . 
C 3 HOH 136 636 601 HOH HOH A . 
C 3 HOH 137 637 661 HOH HOH A . 
C 3 HOH 138 638 620 HOH HOH A . 
C 3 HOH 139 639 660 HOH HOH A . 
C 3 HOH 140 640 610 HOH HOH A . 
C 3 HOH 141 641 577 HOH HOH A . 
C 3 HOH 142 642 510 HOH HOH A . 
C 3 HOH 143 643 584 HOH HOH A . 
C 3 HOH 144 644 602 HOH HOH A . 
C 3 HOH 145 645 668 HOH HOH A . 
C 3 HOH 146 646 586 HOH HOH A . 
C 3 HOH 147 647 591 HOH HOH A . 
C 3 HOH 148 648 658 HOH HOH A . 
C 3 HOH 149 649 692 HOH HOH A . 
C 3 HOH 150 650 650 HOH HOH A . 
C 3 HOH 151 651 651 HOH HOH A . 
C 3 HOH 152 652 565 HOH HOH A . 
C 3 HOH 153 653 523 HOH HOH A . 
C 3 HOH 154 654 623 HOH HOH A . 
C 3 HOH 155 655 502 HOH HOH A . 
C 3 HOH 156 656 672 HOH HOH A . 
C 3 HOH 157 657 504 HOH HOH A . 
C 3 HOH 158 658 542 HOH HOH A . 
C 3 HOH 159 659 616 HOH HOH A . 
C 3 HOH 160 660 679 HOH HOH A . 
C 3 HOH 161 661 503 HOH HOH A . 
C 3 HOH 162 662 681 HOH HOH A . 
C 3 HOH 163 663 639 HOH HOH A . 
C 3 HOH 164 664 568 HOH HOH A . 
C 3 HOH 165 665 638 HOH HOH A . 
C 3 HOH 166 666 696 HOH HOH A . 
C 3 HOH 167 667 538 HOH HOH A . 
C 3 HOH 168 668 597 HOH HOH A . 
C 3 HOH 169 669 615 HOH HOH A . 
C 3 HOH 170 670 571 HOH HOH A . 
C 3 HOH 171 671 625 HOH HOH A . 
C 3 HOH 172 672 685 HOH HOH A . 
C 3 HOH 173 673 665 HOH HOH A . 
C 3 HOH 174 674 515 HOH HOH A . 
C 3 HOH 175 675 677 HOH HOH A . 
C 3 HOH 176 676 644 HOH HOH A . 
C 3 HOH 177 677 695 HOH HOH A . 
C 3 HOH 178 678 667 HOH HOH A . 
C 3 HOH 179 679 637 HOH HOH A . 
C 3 HOH 180 680 606 HOH HOH A . 
C 3 HOH 181 681 522 HOH HOH A . 
C 3 HOH 182 682 613 HOH HOH A . 
C 3 HOH 183 683 563 HOH HOH A . 
C 3 HOH 184 684 532 HOH HOH A . 
C 3 HOH 185 685 611 HOH HOH A . 
C 3 HOH 186 686 697 HOH HOH A . 
C 3 HOH 187 687 689 HOH HOH A . 
C 3 HOH 188 688 678 HOH HOH A . 
C 3 HOH 189 689 691 HOH HOH A . 
C 3 HOH 190 690 617 HOH HOH A . 
C 3 HOH 191 691 687 HOH HOH A . 
C 3 HOH 192 692 647 HOH HOH A . 
C 3 HOH 193 693 673 HOH HOH A . 
C 3 HOH 194 694 688 HOH HOH A . 
C 3 HOH 195 695 614 HOH HOH A . 
C 3 HOH 196 696 641 HOH HOH A . 
C 3 HOH 197 697 694 HOH HOH A . 
C 3 HOH 198 698 636 HOH HOH A . 
C 3 HOH 199 699 690 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0267 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? Blu-Ice  ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YSN 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     49.344 
_cell.length_a_esd                 ? 
_cell.length_b                     73.161 
_cell.length_b_esd                 ? 
_cell.length_c                     101.605 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YSN 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YSN 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.40 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M Bis-Tris pH 6.5, 
0.2 M Sodium fluoride, 
20 % w/v PEG 3350.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-12-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97625 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 07A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97625 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 07A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YSN 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.01 
_reflns.d_resolution_low                               30.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25160 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          27.311 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.01 
_reflns_shell.d_res_low                                     2.08 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2467 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.904 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.021 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            0.655 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            -0.676 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               29.104 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.957 
_refine.correlation_coeff_Fo_to_Fc_free          0.947 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YSN 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.010 
_refine.ls_d_res_low                             22.206 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25097 
_refine.ls_number_reflns_R_free                  1254 
_refine.ls_number_reflns_R_work                  23837 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.635 
_refine.ls_percent_reflns_R_free                 5.021 
_refine.ls_R_factor_all                          0.180 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2082 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1785 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.167 
_refine.pdbx_overall_ESU_R_Free                  0.144 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             3.750 
_refine.overall_SU_ML                            0.101 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2500 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.number_atoms_solvent             199 
_refine_hist.number_atoms_total               2704 
_refine_hist.d_res_high                       2.010 
_refine_hist.d_res_low                        22.206 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.011  0.013  2561 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2378 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.460  1.645  3458 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.393  1.592  5478 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 7.104  5.000  314  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 32.490 22.171 152  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.049 15.000 435  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 12.256 15.000 20   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.079  0.200  314  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  2945 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  619  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.200  0.200  522  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.184  0.200  2143 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.171  0.200  1268 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.081  0.200  1169 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.154  0.200  151  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.166  0.200  13   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.248  0.200  23   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.188  0.200  12   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.963  2.872  1259 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.951  2.869  1258 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.434  4.294  1572 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.434  4.298  1573 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.647  3.187  1302 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.610  3.189  1299 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.684  4.618  1886 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.622  4.619  1881 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 7.397  32.934 2936 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.333  32.738 2900 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.010 2.062  . . 100 1686 97.0125  . . . . 0.243 . . . . . . . . . . . 0.275 
'X-RAY DIFFRACTION' 2.062 2.118  . . 90  1664 100.0000 . . . . 0.214 . . . . . . . . . . . 0.300 
'X-RAY DIFFRACTION' 2.118 2.180  . . 68  1671 100.0000 . . . . 0.194 . . . . . . . . . . . 0.284 
'X-RAY DIFFRACTION' 2.180 2.246  . . 61  1623 100.0000 . . . . 0.195 . . . . . . . . . . . 0.248 
'X-RAY DIFFRACTION' 2.246 2.320  . . 89  1541 99.9387  . . . . 0.193 . . . . . . . . . . . 0.249 
'X-RAY DIFFRACTION' 2.320 2.400  . . 86  1486 100.0000 . . . . 0.175 . . . . . . . . . . . 0.205 
'X-RAY DIFFRACTION' 2.400 2.490  . . 78  1465 100.0000 . . . . 0.172 . . . . . . . . . . . 0.195 
'X-RAY DIFFRACTION' 2.490 2.591  . . 77  1386 100.0000 . . . . 0.171 . . . . . . . . . . . 0.199 
'X-RAY DIFFRACTION' 2.591 2.706  . . 82  1331 99.9293  . . . . 0.181 . . . . . . . . . . . 0.204 
'X-RAY DIFFRACTION' 2.706 2.837  . . 65  1295 100.0000 . . . . 0.194 . . . . . . . . . . . 0.272 
'X-RAY DIFFRACTION' 2.837 2.989  . . 73  1230 100.0000 . . . . 0.175 . . . . . . . . . . . 0.195 
'X-RAY DIFFRACTION' 2.989 3.168  . . 59  1163 100.0000 . . . . 0.192 . . . . . . . . . . . 0.231 
'X-RAY DIFFRACTION' 3.168 3.384  . . 66  1102 100.0000 . . . . 0.187 . . . . . . . . . . . 0.203 
'X-RAY DIFFRACTION' 3.384 3.651  . . 63  1024 100.0000 . . . . 0.195 . . . . . . . . . . . 0.253 
'X-RAY DIFFRACTION' 3.651 3.994  . . 49  949  100.0000 . . . . 0.170 . . . . . . . . . . . 0.207 
'X-RAY DIFFRACTION' 3.994 4.455  . . 50  877  100.0000 . . . . 0.135 . . . . . . . . . . . 0.146 
'X-RAY DIFFRACTION' 4.455 5.126  . . 38  789  100.0000 . . . . 0.142 . . . . . . . . . . . 0.147 
'X-RAY DIFFRACTION' 5.126 6.232  . . 24  678  100.0000 . . . . 0.187 . . . . . . . . . . . 0.188 
'X-RAY DIFFRACTION' 6.232 8.630  . . 25  544  100.0000 . . . . 0.161 . . . . . . . . . . . 0.132 
'X-RAY DIFFRACTION' 8.630 22.206 . . 17  333  95.1087  . . . . 0.170 . . . . . . . . . . . 0.141 
# 
_struct.entry_id                     8YSN 
_struct.title                        'Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB Ear-cut mutant' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YSN 
_struct_keywords.text            'CD-NTase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A345ILN6_9DEIO 
_struct_ref.pdbx_db_accession          A0A345ILN6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YSN 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 334 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A345ILN6 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  348 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       334 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YSN ?   A ?   ? UNP A0A345ILN6 ARG 224 deletion ?   1  
1 8YSN ?   A ?   ? UNP A0A345ILN6 THR 225 deletion ?   2  
1 8YSN ?   A ?   ? UNP A0A345ILN6 ASP 226 deletion ?   3  
1 8YSN ?   A ?   ? UNP A0A345ILN6 PRO 227 deletion ?   4  
1 8YSN ?   A ?   ? UNP A0A345ILN6 VAL 228 deletion ?   5  
1 8YSN ?   A ?   ? UNP A0A345ILN6 SER 229 deletion ?   6  
1 8YSN ?   A ?   ? UNP A0A345ILN6 GLN 230 deletion ?   7  
1 8YSN GLY A 224 ? UNP A0A345ILN6 ASN 231 conflict 224 8  
1 8YSN SER A 225 ? UNP A0A345ILN6 VAL 232 conflict 225 9  
1 8YSN GLY A 226 ? UNP A0A345ILN6 THR 233 conflict 226 10 
1 8YSN ?   A ?   ? UNP A0A345ILN6 THR 254 deletion ?   11 
1 8YSN ?   A ?   ? UNP A0A345ILN6 TRP 255 deletion ?   12 
1 8YSN ?   A ?   ? UNP A0A345ILN6 ASP 256 deletion ?   13 
1 8YSN ?   A ?   ? UNP A0A345ILN6 SER 257 deletion ?   14 
1 8YSN ?   A ?   ? UNP A0A345ILN6 LYS 258 deletion ?   15 
1 8YSN ?   A ?   ? UNP A0A345ILN6 ASP 259 deletion ?   16 
1 8YSN ?   A ?   ? UNP A0A345ILN6 GLN 260 deletion ?   17 
1 8YSN GLY A 247 ? UNP A0A345ILN6 ARG 261 conflict 247 18 
1 8YSN GLY A 249 ? UNP A0A345ILN6 TYR 263 conflict 249 19 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 220   ? 
1 MORE         -5    ? 
1 'SSA (A^2)'  14720 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 4   ? LYS A 16  ? VAL A 4   LYS A 16  1 ? 13 
HELX_P HELX_P2  AA2 GLN A 19  ? GLU A 22  ? GLN A 19  GLU A 22  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 23  ? ASP A 47  ? ASN A 23  ASP A 47  1 ? 25 
HELX_P HELX_P4  AA4 GLY A 61  ? ASN A 66  ? GLY A 61  ASN A 66  1 ? 6  
HELX_P HELX_P5  AA5 ALA A 88  ? HIS A 92  ? ALA A 88  HIS A 92  5 ? 5  
HELX_P HELX_P6  AA6 ASP A 93  ? LEU A 105 ? ASP A 93  LEU A 105 1 ? 13 
HELX_P HELX_P7  AA7 PRO A 136 ? GLY A 140 ? PRO A 136 GLY A 140 5 ? 5  
HELX_P HELX_P8  AA8 GLY A 153 ? ARG A 157 ? GLY A 153 ARG A 157 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 163 ? LYS A 174 ? ASP A 163 LYS A 174 1 ? 12 
HELX_P HELX_P10 AB1 SER A 176 ? PHE A 198 ? SER A 176 PHE A 198 1 ? 23 
HELX_P HELX_P11 AB2 LEU A 207 ? PHE A 219 ? LEU A 207 PHE A 219 1 ? 13 
HELX_P HELX_P12 AB3 ASP A 228 ? ASN A 243 ? ASP A 228 ASN A 243 1 ? 16 
HELX_P HELX_P13 AB4 THR A 269 ? ARG A 293 ? THR A 269 ARG A 293 1 ? 25 
HELX_P HELX_P14 AB5 GLU A 295 ? GLY A 308 ? GLU A 295 GLY A 308 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           259 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            259 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    260 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     260 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -0.16 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? ASN A 59  ? PHE A 55  ASN A 59  
AA1 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA1 3 TYR A 126 ? ALA A 134 ? TYR A 126 ALA A 134 
AA1 4 VAL A 119 ? LYS A 123 ? VAL A 119 LYS A 123 
AA1 5 ALA A 112 ? ILE A 114 ? ALA A 112 ILE A 114 
AA2 1 CYS A 144 ? LYS A 147 ? CYS A 144 LYS A 147 
AA2 2 LEU A 158 ? ILE A 161 ? LEU A 158 ILE A 161 
AA3 1 PHE A 244 ? ASP A 246 ? PHE A 244 ASP A 246 
AA3 2 PRO A 250 ? LEU A 252 ? PRO A 250 LEU A 252 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 58  ? N PHE A 58  O GLY A 82  ? O GLY A 82  
AA1 2 3 N ILE A 83  ? N ILE A 83  O ALA A 131 ? O ALA A 131 
AA1 3 4 O LEU A 130 ? O LEU A 130 N VAL A 119 ? N VAL A 119 
AA1 4 5 O THR A 120 ? O THR A 120 N GLU A 113 ? N GLU A 113 
AA2 1 2 N LYS A 147 ? N LYS A 147 O LEU A 158 ? O LEU A 158 
AA3 1 2 N HIS A 245 ? N HIS A 245 O ARG A 251 ? O ARG A 251 
# 
_pdbx_entry_details.entry_id                   8YSN 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    ASP 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     163 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -148.64 
_pdbx_validate_torsion.psi             58.58 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ASP 317 ? A ASP 317 
3  1 Y 1 A LYS 318 ? A LYS 318 
4  1 Y 1 A SER 319 ? A SER 319 
5  1 Y 1 A ALA 320 ? A ALA 320 
6  1 Y 1 A VAL 321 ? A VAL 321 
7  1 Y 1 A HIS 322 ? A HIS 322 
8  1 Y 1 A THR 323 ? A THR 323 
9  1 Y 1 A ALA 324 ? A ALA 324 
10 1 Y 1 A PRO 325 ? A PRO 325 
11 1 Y 1 A ALA 326 ? A ALA 326 
12 1 Y 1 A ILE 327 ? A ILE 327 
13 1 Y 1 A VAL 328 ? A VAL 328 
14 1 Y 1 A GLY 329 ? A GLY 329 
15 1 Y 1 A SER 330 ? A SER 330 
16 1 Y 1 A GLY 331 ? A GLY 331 
17 1 Y 1 A SER 332 ? A SER 332 
18 1 Y 1 A SER 333 ? A SER 333 
19 1 Y 1 A GLY 334 ? A GLY 334 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PO4 P    P N N 273 
PO4 O1   O N N 274 
PO4 O2   O N N 275 
PO4 O3   O N N 276 
PO4 O4   O N N 277 
PRO N    N N N 278 
PRO CA   C N S 279 
PRO C    C N N 280 
PRO O    O N N 281 
PRO CB   C N N 282 
PRO CG   C N N 283 
PRO CD   C N N 284 
PRO OXT  O N N 285 
PRO H    H N N 286 
PRO HA   H N N 287 
PRO HB2  H N N 288 
PRO HB3  H N N 289 
PRO HG2  H N N 290 
PRO HG3  H N N 291 
PRO HD2  H N N 292 
PRO HD3  H N N 293 
PRO HXT  H N N 294 
SER N    N N N 295 
SER CA   C N S 296 
SER C    C N N 297 
SER O    O N N 298 
SER CB   C N N 299 
SER OG   O N N 300 
SER OXT  O N N 301 
SER H    H N N 302 
SER H2   H N N 303 
SER HA   H N N 304 
SER HB2  H N N 305 
SER HB3  H N N 306 
SER HG   H N N 307 
SER HXT  H N N 308 
THR N    N N N 309 
THR CA   C N S 310 
THR C    C N N 311 
THR O    O N N 312 
THR CB   C N R 313 
THR OG1  O N N 314 
THR CG2  C N N 315 
THR OXT  O N N 316 
THR H    H N N 317 
THR H2   H N N 318 
THR HA   H N N 319 
THR HB   H N N 320 
THR HG1  H N N 321 
THR HG21 H N N 322 
THR HG22 H N N 323 
THR HG23 H N N 324 
THR HXT  H N N 325 
TRP N    N N N 326 
TRP CA   C N S 327 
TRP C    C N N 328 
TRP O    O N N 329 
TRP CB   C N N 330 
TRP CG   C Y N 331 
TRP CD1  C Y N 332 
TRP CD2  C Y N 333 
TRP NE1  N Y N 334 
TRP CE2  C Y N 335 
TRP CE3  C Y N 336 
TRP CZ2  C Y N 337 
TRP CZ3  C Y N 338 
TRP CH2  C Y N 339 
TRP OXT  O N N 340 
TRP H    H N N 341 
TRP H2   H N N 342 
TRP HA   H N N 343 
TRP HB2  H N N 344 
TRP HB3  H N N 345 
TRP HD1  H N N 346 
TRP HE1  H N N 347 
TRP HE3  H N N 348 
TRP HZ2  H N N 349 
TRP HZ3  H N N 350 
TRP HH2  H N N 351 
TRP HXT  H N N 352 
TYR N    N N N 353 
TYR CA   C N S 354 
TYR C    C N N 355 
TYR O    O N N 356 
TYR CB   C N N 357 
TYR CG   C Y N 358 
TYR CD1  C Y N 359 
TYR CD2  C Y N 360 
TYR CE1  C Y N 361 
TYR CE2  C Y N 362 
TYR CZ   C Y N 363 
TYR OH   O N N 364 
TYR OXT  O N N 365 
TYR H    H N N 366 
TYR H2   H N N 367 
TYR HA   H N N 368 
TYR HB2  H N N 369 
TYR HB3  H N N 370 
TYR HD1  H N N 371 
TYR HD2  H N N 372 
TYR HE1  H N N 373 
TYR HE2  H N N 374 
TYR HH   H N N 375 
TYR HXT  H N N 376 
VAL N    N N N 377 
VAL CA   C N S 378 
VAL C    C N N 379 
VAL O    O N N 380 
VAL CB   C N N 381 
VAL CG1  C N N 382 
VAL CG2  C N N 383 
VAL OXT  O N N 384 
VAL H    H N N 385 
VAL H2   H N N 386 
VAL HA   H N N 387 
VAL HB   H N N 388 
VAL HG11 H N N 389 
VAL HG12 H N N 390 
VAL HG13 H N N 391 
VAL HG21 H N N 392 
VAL HG22 H N N 393 
VAL HG23 H N N 394 
VAL HXT  H N N 395 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PO4 P   O1   doub N N 260 
PO4 P   O2   sing N N 261 
PO4 P   O3   sing N N 262 
PO4 P   O4   sing N N 263 
PRO N   CA   sing N N 264 
PRO N   CD   sing N N 265 
PRO N   H    sing N N 266 
PRO CA  C    sing N N 267 
PRO CA  CB   sing N N 268 
PRO CA  HA   sing N N 269 
PRO C   O    doub N N 270 
PRO C   OXT  sing N N 271 
PRO CB  CG   sing N N 272 
PRO CB  HB2  sing N N 273 
PRO CB  HB3  sing N N 274 
PRO CG  CD   sing N N 275 
PRO CG  HG2  sing N N 276 
PRO CG  HG3  sing N N 277 
PRO CD  HD2  sing N N 278 
PRO CD  HD3  sing N N 279 
PRO OXT HXT  sing N N 280 
SER N   CA   sing N N 281 
SER N   H    sing N N 282 
SER N   H2   sing N N 283 
SER CA  C    sing N N 284 
SER CA  CB   sing N N 285 
SER CA  HA   sing N N 286 
SER C   O    doub N N 287 
SER C   OXT  sing N N 288 
SER CB  OG   sing N N 289 
SER CB  HB2  sing N N 290 
SER CB  HB3  sing N N 291 
SER OG  HG   sing N N 292 
SER OXT HXT  sing N N 293 
THR N   CA   sing N N 294 
THR N   H    sing N N 295 
THR N   H2   sing N N 296 
THR CA  C    sing N N 297 
THR CA  CB   sing N N 298 
THR CA  HA   sing N N 299 
THR C   O    doub N N 300 
THR C   OXT  sing N N 301 
THR CB  OG1  sing N N 302 
THR CB  CG2  sing N N 303 
THR CB  HB   sing N N 304 
THR OG1 HG1  sing N N 305 
THR CG2 HG21 sing N N 306 
THR CG2 HG22 sing N N 307 
THR CG2 HG23 sing N N 308 
THR OXT HXT  sing N N 309 
TRP N   CA   sing N N 310 
TRP N   H    sing N N 311 
TRP N   H2   sing N N 312 
TRP CA  C    sing N N 313 
TRP CA  CB   sing N N 314 
TRP CA  HA   sing N N 315 
TRP C   O    doub N N 316 
TRP C   OXT  sing N N 317 
TRP CB  CG   sing N N 318 
TRP CB  HB2  sing N N 319 
TRP CB  HB3  sing N N 320 
TRP CG  CD1  doub Y N 321 
TRP CG  CD2  sing Y N 322 
TRP CD1 NE1  sing Y N 323 
TRP CD1 HD1  sing N N 324 
TRP CD2 CE2  doub Y N 325 
TRP CD2 CE3  sing Y N 326 
TRP NE1 CE2  sing Y N 327 
TRP NE1 HE1  sing N N 328 
TRP CE2 CZ2  sing Y N 329 
TRP CE3 CZ3  doub Y N 330 
TRP CE3 HE3  sing N N 331 
TRP CZ2 CH2  doub Y N 332 
TRP CZ2 HZ2  sing N N 333 
TRP CZ3 CH2  sing Y N 334 
TRP CZ3 HZ3  sing N N 335 
TRP CH2 HH2  sing N N 336 
TRP OXT HXT  sing N N 337 
TYR N   CA   sing N N 338 
TYR N   H    sing N N 339 
TYR N   H2   sing N N 340 
TYR CA  C    sing N N 341 
TYR CA  CB   sing N N 342 
TYR CA  HA   sing N N 343 
TYR C   O    doub N N 344 
TYR C   OXT  sing N N 345 
TYR CB  CG   sing N N 346 
TYR CB  HB2  sing N N 347 
TYR CB  HB3  sing N N 348 
TYR CG  CD1  doub Y N 349 
TYR CG  CD2  sing Y N 350 
TYR CD1 CE1  sing Y N 351 
TYR CD1 HD1  sing N N 352 
TYR CD2 CE2  doub Y N 353 
TYR CD2 HD2  sing N N 354 
TYR CE1 CZ   doub Y N 355 
TYR CE1 HE1  sing N N 356 
TYR CE2 CZ   sing Y N 357 
TYR CE2 HE2  sing N N 358 
TYR CZ  OH   sing N N 359 
TYR OH  HH   sing N N 360 
TYR OXT HXT  sing N N 361 
VAL N   CA   sing N N 362 
VAL N   H    sing N N 363 
VAL N   H2   sing N N 364 
VAL CA  C    sing N N 365 
VAL CA  CB   sing N N 366 
VAL CA  HA   sing N N 367 
VAL C   O    doub N N 368 
VAL C   OXT  sing N N 369 
VAL CB  CG1  sing N N 370 
VAL CB  CG2  sing N N 371 
VAL CB  HB   sing N N 372 
VAL CG1 HG11 sing N N 373 
VAL CG1 HG12 sing N N 374 
VAL CG1 HG13 sing N N 375 
VAL CG2 HG21 sing N N 376 
VAL CG2 HG22 sing N N 377 
VAL CG2 HG23 sing N N 378 
VAL OXT HXT  sing N N 379 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           111-2311-B-039-001-MY3 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'apo DwCdnB' 
# 
_atom_sites.entry_id                    8YSN 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020266 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013668 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009842 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
P 15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491 68.164 1.115   
S 16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . ALA A 1 2   ? -26.672 23.585  24.672  1.000 35.497  0 2   ALA A N   1 ? 
ATOM   2    C CA  . ALA A 1 2   ? -26.633 22.688  25.916  1.000 39.447  0 2   ALA A CA  1 ? 
ATOM   3    C C   . ALA A 1 2   ? -25.500 21.658  25.775  1.000 41.111  0 2   ALA A C   1 ? 
ATOM   4    O O   . ALA A 1 2   ? -24.945 21.479  24.674  1.000 39.456  0 2   ALA A O   1 ? 
ATOM   5    C CB  . ALA A 1 2   ? -27.987 22.013  26.112  1.000 39.010  0 2   ALA A CB  1 ? 
ATOM   6    N N   . PRO A 1 3   ? -25.102 20.956  26.869  1.000 39.067  0 3   PRO A N   1 ? 
ATOM   7    C CA  . PRO A 1 3   ? -24.243 19.781  26.728  1.000 31.835  0 3   PRO A CA  1 ? 
ATOM   8    C C   . PRO A 1 3   ? -25.065 18.638  26.118  1.000 27.618  0 3   PRO A C   1 ? 
ATOM   9    O O   . PRO A 1 3   ? -26.191 18.414  26.526  1.000 27.636  0 3   PRO A O   1 ? 
ATOM   10   C CB  . PRO A 1 3   ? -23.747 19.486  28.150  1.000 38.769  0 3   PRO A CB  1 ? 
ATOM   11   C CG  . PRO A 1 3   ? -24.800 20.151  29.067  1.000 41.007  0 3   PRO A CG  1 ? 
ATOM   12   C CD  . PRO A 1 3   ? -25.394 21.298  28.274  1.000 37.964  0 3   PRO A CD  1 ? 
ATOM   13   N N   . VAL A 1 4   ? -24.507 17.975  25.122  1.000 24.270  0 4   VAL A N   1 ? 
ATOM   14   C CA  . VAL A 1 4   ? -25.195 16.906  24.340  1.000 23.237  0 4   VAL A CA  1 ? 
ATOM   15   C C   . VAL A 1 4   ? -24.306 15.663  24.224  1.000 21.812  0 4   VAL A C   1 ? 
ATOM   16   O O   . VAL A 1 4   ? -24.646 14.804  23.391  1.000 21.523  0 4   VAL A O   1 ? 
ATOM   17   C CB  . VAL A 1 4   ? -25.584 17.435  22.949  1.000 22.961  0 4   VAL A CB  1 ? 
ATOM   18   C CG1 . VAL A 1 4   ? -26.745 18.437  23.018  1.000 22.579  0 4   VAL A CG1 1 ? 
ATOM   19   C CG2 . VAL A 1 4   ? -24.391 18.017  22.213  1.000 21.520  0 4   VAL A CG2 1 ? 
ATOM   20   N N   . GLN A 1 5   ? -23.231 15.549  25.031  1.000 22.061  0 5   GLN A N   1 ? 
ATOM   21   C CA  . GLN A 1 5   ? -22.264 14.417  24.957  1.000 21.435  0 5   GLN A CA  1 ? 
ATOM   22   C C   . GLN A 1 5   ? -22.988 13.108  25.296  1.000 22.316  0 5   GLN A C   1 ? 
ATOM   23   O O   . GLN A 1 5   ? -22.798 12.099  24.575  1.000 20.286  0 5   GLN A O   1 ? 
ATOM   24   C CB  . GLN A 1 5   ? -21.059 14.636  25.875  1.000 21.780  0 5   GLN A CB  1 ? 
ATOM   25   C CG  . GLN A 1 5   ? -19.994 13.554  25.742  1.000 20.620  0 5   GLN A CG  1 ? 
ATOM   26   C CD  . GLN A 1 5   ? -19.457 13.426  24.328  1.000 21.165  0 5   GLN A CD  1 ? 
ATOM   27   O OE1 . GLN A 1 5   ? -19.612 14.312  23.484  1.000 19.500  0 5   GLN A OE1 1 ? 
ATOM   28   N NE2 . GLN A 1 5   ? -18.768 12.334  24.071  1.000 20.024  0 5   GLN A NE2 1 ? 
ATOM   29   N N   . LYS A 1 6   ? -23.901 13.138  26.263  1.000 22.327  0 6   LYS A N   1 ? 
ATOM   30   C CA  . LYS A 1 6   ? -24.685 11.932  26.640  1.000 21.647  0 6   LYS A CA  1 ? 
ATOM   31   C C   . LYS A 1 6   ? -25.494 11.445  25.433  1.000 21.510  0 6   LYS A C   1 ? 
ATOM   32   O O   . LYS A 1 6   ? -25.457 10.250  25.148  1.000 20.385  0 6   LYS A O   1 ? 
ATOM   33   C CB  . LYS A 1 6   ? -25.644 12.238  27.790  1.000 24.643  0 6   LYS A CB  1 ? 
ATOM   34   C CG  . LYS A 1 6   ? -26.458 11.045  28.261  1.000 29.060  0 6   LYS A CG  1 ? 
ATOM   35   C CD  . LYS A 1 6   ? -27.437 11.440  29.358  1.000 30.643  0 6   LYS A CD  1 ? 
ATOM   36   C CE  . LYS A 1 6   ? -28.246 10.273  29.869  1.000 34.175  0 6   LYS A CE  1 ? 
ATOM   37   N NZ  . LYS A 1 6   ? -29.024 10.692  31.061  1.000 40.893  0 6   LYS A NZ  1 ? 
ATOM   38   N N   . GLN A 1 7   ? -26.160 12.352  24.721  1.000 20.110  0 7   GLN A N   1 ? 
ATOM   39   C CA  . GLN A 1 7   ? -27.001 11.998  23.555  1.000 20.864  0 7   GLN A CA  1 ? 
ATOM   40   C C   . GLN A 1 7   ? -26.121 11.517  22.381  1.000 20.299  0 7   GLN A C   1 ? 
ATOM   41   O O   . GLN A 1 7   ? -26.524 10.581  21.715  1.000 20.976  0 7   GLN A O   1 ? 
ATOM   42   C CB  . GLN A 1 7   ? -27.892 13.173  23.171  1.000 21.903  0 7   GLN A CB  1 ? 
ATOM   43   C CG  . GLN A 1 7   ? -29.072 13.385  24.139  1.000 25.103  0 7   GLN A CG  1 ? 
ATOM   44   C CD  . GLN A 1 7   ? -28.654 13.871  25.516  1.000 26.084  0 7   GLN A CD  1 ? 
ATOM   45   O OE1 . GLN A 1 7   ? -27.764 14.695  25.672  1.000 25.153  0 7   GLN A OE1 1 ? 
ATOM   46   N NE2 . GLN A 1 7   ? -29.310 13.363  26.547  1.000 26.741  0 7   GLN A NE2 1 ? 
ATOM   47   N N   . PHE A 1 8   ? -24.949 12.109  22.151  1.000 19.981  0 8   PHE A N   1 ? 
ATOM   48   C CA  . PHE A 1 8   ? -24.013 11.614  21.098  1.000 18.975  0 8   PHE A CA  1 ? 
ATOM   49   C C   . PHE A 1 8   ? -23.621 10.179  21.417  1.000 18.554  0 8   PHE A C   1 ? 
ATOM   50   O O   . PHE A 1 8   ? -23.669 9.328   20.503  1.000 20.361  0 8   PHE A O   1 ? 
ATOM   51   C CB  . PHE A 1 8   ? -22.795 12.520  20.948  1.000 18.976  0 8   PHE A CB  1 ? 
ATOM   52   C CG  . PHE A 1 8   ? -22.966 13.553  19.879  1.000 18.343  0 8   PHE A CG  1 ? 
ATOM   53   C CD1 . PHE A 1 8   ? -22.888 13.190  18.541  1.000 18.843  0 8   PHE A CD1 1 ? 
ATOM   54   C CD2 . PHE A 1 8   ? -23.197 14.876  20.193  1.000 17.535  0 8   PHE A CD2 1 ? 
ATOM   55   C CE1 . PHE A 1 8   ? -23.086 14.132  17.549  1.000 17.885  0 8   PHE A CE1 1 ? 
ATOM   56   C CE2 . PHE A 1 8   ? -23.389 15.817  19.193  1.000 18.522  0 8   PHE A CE2 1 ? 
ATOM   57   C CZ  . PHE A 1 8   ? -23.307 15.450  17.882  1.000 18.192  0 8   PHE A CZ  1 ? 
ATOM   58   N N   . ARG A 1 9   ? -23.290 9.890   22.685  1.000 20.157  0 9   ARG A N   1 ? 
ATOM   59   C CA  . ARG A 1 9   ? -22.854 8.535   23.075  1.000 20.296  0 9   ARG A CA  1 ? 
ATOM   60   C C   . ARG A 1 9   ? -24.008 7.541   22.900  1.000 20.244  0 9   ARG A C   1 ? 
ATOM   61   O O   . ARG A 1 9   ? -23.727 6.407   22.418  1.000 19.268  0 9   ARG A O   1 ? 
ATOM   62   C CB  . ARG A 1 9   ? -22.247 8.483   24.486  1.000 22.423  0 9   ARG A CB  1 ? 
ATOM   63   C CG  . ARG A 1 9   ? -20.895 9.180   24.646  1.000 23.074  0 9   ARG A CG  1 ? 
ATOM   64   C CD  . ARG A 1 9   ? -19.825 8.731   23.669  1.000 23.535  0 9   ARG A CD  1 ? 
ATOM   65   N NE  . ARG A 1 9   ? -19.393 7.363   23.852  1.000 25.421  0 9   ARG A NE  1 ? 
ATOM   66   C CZ  . ARG A 1 9   ? -18.409 6.977   24.661  1.000 25.010  0 9   ARG A CZ  1 ? 
ATOM   67   N NH1 . ARG A 1 9   ? -17.771 7.850   25.412  1.000 25.935  0 9   ARG A NH1 1 ? 
ATOM   68   N NH2 . ARG A 1 9   ? -18.067 5.714   24.713  1.000 25.252  0 9   ARG A NH2 1 ? 
ATOM   69   N N   . GLU A 1 10  ? -25.243 7.918   23.229  1.000 21.720  0 10  GLU A N   1 ? 
ATOM   70   C CA  . GLU A 1 10  ? -26.408 7.018   23.030  1.000 24.215  0 10  GLU A CA  1 ? 
ATOM   71   C C   . GLU A 1 10  ? -26.605 6.834   21.536  1.000 20.881  0 10  GLU A C   1 ? 
ATOM   72   O O   . GLU A 1 10  ? -26.868 5.708   21.113  1.000 19.542  0 10  GLU A O   1 ? 
ATOM   73   C CB  . GLU A 1 10  ? -27.712 7.538   23.644  1.000 28.620  0 10  GLU A CB  1 ? 
ATOM   74   C CG  . GLU A 1 10  ? -27.638 7.747   25.143  1.000 37.260  0 10  GLU A CG  1 ? 
ATOM   75   C CD  . GLU A 1 10  ? -28.811 8.515   25.756  1.000 39.081  0 10  GLU A CD  1 ? 
ATOM   76   O OE1 . GLU A 1 10  ? -29.536 9.184   25.001  1.000 41.087  0 10  GLU A OE1 1 ? 
ATOM   77   O OE2 . GLU A 1 10  ? -28.957 8.482   27.000  1.000 44.730  0 10  GLU A OE2 1 ? 
ATOM   78   N N   . PHE A 1 11  ? -26.491 7.915   20.760  1.000 20.568  0 11  PHE A N   1 ? 
ATOM   79   C CA  . PHE A 1 11  ? -26.585 7.844   19.278  1.000 20.740  0 11  PHE A CA  1 ? 
ATOM   80   C C   . PHE A 1 11  ? -25.529 6.868   18.768  1.000 20.918  0 11  PHE A C   1 ? 
ATOM   81   O O   . PHE A 1 11  ? -25.814 5.992   17.895  1.000 21.387  0 11  PHE A O   1 ? 
ATOM   82   C CB  . PHE A 1 11  ? -26.418 9.235   18.664  1.000 20.663  0 11  PHE A CB  1 ? 
ATOM   83   C CG  . PHE A 1 11  ? -26.440 9.307   17.153  1.000 19.178  0 11  PHE A CG  1 ? 
ATOM   84   C CD1 . PHE A 1 11  ? -27.518 8.836   16.420  1.000 21.094  0 11  PHE A CD1 1 ? 
ATOM   85   C CD2 . PHE A 1 11  ? -25.402 9.924   16.463  1.000 20.097  0 11  PHE A CD2 1 ? 
ATOM   86   C CE1 . PHE A 1 11  ? -27.535 8.926   15.033  1.000 20.368  0 11  PHE A CE1 1 ? 
ATOM   87   C CE2 . PHE A 1 11  ? -25.443 10.063  15.078  1.000 19.681  0 11  PHE A CE2 1 ? 
ATOM   88   C CZ  . PHE A 1 11  ? -26.497 9.542   14.359  1.000 19.921  0 11  PHE A CZ  1 ? 
ATOM   89   N N   . HIS A 1 12  ? -24.304 6.997   19.260  1.000 20.743  0 12  HIS A N   1 ? 
ATOM   90   C CA  . HIS A 1 12  ? -23.209 6.142   18.755  1.000 21.324  0 12  HIS A CA  1 ? 
ATOM   91   C C   . HIS A 1 12  ? -23.579 4.671   19.018  1.000 21.682  0 12  HIS A C   1 ? 
ATOM   92   O O   . HIS A 1 12  ? -23.380 3.839   18.130  1.000 21.722  0 12  HIS A O   1 ? 
ATOM   93   C CB  . HIS A 1 12  ? -21.873 6.544   19.392  1.000 20.754  0 12  HIS A CB  1 ? 
ATOM   94   C CG  . HIS A 1 12  ? -20.766 5.677   18.938  1.000 21.649  0 12  HIS A CG  1 ? 
ATOM   95   N ND1 . HIS A 1 12  ? -20.266 4.669   19.732  1.000 19.877  0 12  HIS A ND1 1 ? 
ATOM   96   C CD2 . HIS A 1 12  ? -20.127 5.594   17.740  1.000 21.839  0 12  HIS A CD2 1 ? 
ATOM   97   C CE1 . HIS A 1 12  ? -19.339 4.016   19.062  1.000 20.150  0 12  HIS A CE1 1 ? 
ATOM   98   N NE2 . HIS A 1 12  ? -19.225 4.562   17.839  1.000 17.916  0 12  HIS A NE2 1 ? 
ATOM   99   N N   . ASP A 1 13  ? -24.088 4.357   20.211  1.000 23.797  0 13  ASP A N   1 ? 
ATOM   100  C CA  . ASP A 1 13  ? -24.478 2.975   20.586  1.000 26.353  0 13  ASP A CA  1 ? 
ATOM   101  C C   . ASP A 1 13  ? -25.535 2.457   19.616  1.000 27.302  0 13  ASP A C   1 ? 
ATOM   102  O O   . ASP A 1 13  ? -25.455 1.297   19.255  1.000 28.428  0 13  ASP A O   1 ? 
ATOM   103  C CB  . ASP A 1 13  ? -25.045 2.883   21.994  1.000 32.224  0 13  ASP A CB  1 ? 
ATOM   104  C CG  . ASP A 1 13  ? -24.026 3.156   23.074  1.000 34.334  0 13  ASP A CG  1 ? 
ATOM   105  O OD1 . ASP A 1 13  ? -22.840 2.857   22.854  1.000 32.823  0 13  ASP A OD1 1 ? 
ATOM   106  O OD2 . ASP A 1 13  ? -24.426 3.691   24.099  1.000 38.517  0 13  ASP A OD2 1 ? 
ATOM   107  N N   . ARG A 1 14  ? -26.466 3.293   19.165  1.000 26.690  0 14  ARG A N   1 ? 
ATOM   108  C CA  . ARG A 1 14  ? -27.490 2.841   18.192  1.000 25.772  0 14  ARG A CA  1 ? 
ATOM   109  C C   . ARG A 1 14  ? -26.890 2.572   16.801  1.000 24.840  0 14  ARG A C   1 ? 
ATOM   110  O O   . ARG A 1 14  ? -27.426 1.709   16.095  1.000 25.248  0 14  ARG A O   1 ? 
ATOM   111  C CB  . ARG A 1 14  ? -28.615 3.856   18.130  1.000 27.473  0 14  ARG A CB  1 ? 
ATOM   112  C CG  . ARG A 1 14  ? -29.297 4.019   19.482  1.000 32.736  0 14  ARG A CG  1 ? 
ATOM   113  C CD  . ARG A 1 14  ? -30.283 5.160   19.475  1.000 36.389  0 14  ARG A CD  1 ? 
ATOM   114  N NE  . ARG A 1 14  ? -31.014 5.256   20.731  1.000 39.842  0 14  ARG A NE  1 ? 
ATOM   115  C CZ  . ARG A 1 14  ? -31.882 6.209   21.023  1.000 41.736  0 14  ARG A CZ  1 ? 
ATOM   116  N NH1 . ARG A 1 14  ? -32.145 7.169   20.152  1.000 37.925  0 14  ARG A NH1 1 ? 
ATOM   117  N NH2 . ARG A 1 14  ? -32.488 6.201   22.195  1.000 52.090  0 14  ARG A NH2 1 ? 
ATOM   118  N N   . ILE A 1 15  ? -25.887 3.323   16.347  1.000 21.856  0 15  ILE A N   1 ? 
ATOM   119  C CA  . ILE A 1 15  ? -25.505 3.290   14.908  1.000 21.446  0 15  ILE A CA  1 ? 
ATOM   120  C C   . ILE A 1 15  ? -24.345 2.307   14.696  1.000 21.864  0 15  ILE A C   1 ? 
ATOM   121  O O   . ILE A 1 15  ? -24.116 1.894   13.534  1.000 22.207  0 15  ILE A O   1 ? 
ATOM   122  C CB  . ILE A 1 15  ? -25.150 4.695   14.375  1.000 21.894  0 15  ILE A CB  1 ? 
ATOM   123  C CG1 . ILE A 1 15  ? -23.888 5.275   15.023  1.000 21.556  0 15  ILE A CG1 1 ? 
ATOM   124  C CG2 . ILE A 1 15  ? -26.356 5.649   14.481  1.000 22.183  0 15  ILE A CG2 1 ? 
ATOM   125  C CD1 . ILE A 1 15  ? -23.439 6.589   14.390  1.000 22.502  0 15  ILE A CD1 1 ? 
ATOM   126  N N   . LYS A 1 16  ? -23.578 2.037   15.741  1.000 22.459  0 16  LYS A N   1 ? 
ATOM   127  C CA  . LYS A 1 16  ? -22.346 1.220   15.647  1.000 25.904  0 16  LYS A CA  1 ? 
ATOM   128  C C   . LYS A 1 16  ? -22.660 -0.182  15.120  1.000 26.018  0 16  LYS A C   1 ? 
ATOM   129  O O   . LYS A 1 16  ? -23.628 -0.798  15.593  1.000 23.205  0 16  LYS A O   1 ? 
ATOM   130  C CB  . LYS A 1 16  ? -21.671 1.101   17.004  1.000 27.156  0 16  LYS A CB  1 ? 
ATOM   131  C CG  . LYS A 1 16  ? -20.393 0.304   16.933  1.000 32.768  0 16  LYS A CG  1 ? 
ATOM   132  C CD  . LYS A 1 16  ? -19.799 -0.062  18.257  1.000 36.828  0 16  LYS A CD  1 ? 
ATOM   133  C CE  . LYS A 1 16  ? -18.783 -1.185  18.102  1.000 35.443  0 16  LYS A CE  1 ? 
ATOM   134  N NZ  . LYS A 1 16  ? -17.919 -1.298  19.307  1.000 39.628  0 16  LYS A NZ  1 ? 
ATOM   135  N N   . LEU A 1 17  ? -21.874 -0.667  14.158  1.000 27.937  0 17  LEU A N   1 ? 
ATOM   136  C CA  . LEU A 1 17  ? -21.910 -2.095  13.742  1.000 29.030  0 17  LEU A CA  1 ? 
ATOM   137  C C   . LEU A 1 17  ? -20.539 -2.703  13.994  1.000 29.098  0 17  LEU A C   1 ? 
ATOM   138  O O   . LEU A 1 17  ? -19.529 -2.163  13.461  1.000 31.017  0 17  LEU A O   1 ? 
ATOM   139  C CB  . LEU A 1 17  ? -22.344 -2.217  12.284  1.000 27.347  0 17  LEU A CB  1 ? 
ATOM   140  C CG  . LEU A 1 17  ? -22.557 -3.642  11.772  1.000 30.401  0 17  LEU A CG  1 ? 
ATOM   141  C CD1 . LEU A 1 17  ? -23.534 -4.392  12.660  1.000 31.677  0 17  LEU A CD1 1 ? 
ATOM   142  C CD2 . LEU A 1 17  ? -23.052 -3.641  10.327  1.000 29.363  0 17  LEU A CD2 1 ? 
ATOM   143  N N   . ALA A 1 18  ? -20.475 -3.731  14.835  1.000 25.281  0 18  ALA A N   1 ? 
ATOM   144  C CA  . ALA A 1 18  ? -19.183 -4.262  15.314  1.000 23.929  0 18  ALA A CA  1 ? 
ATOM   145  C C   . ALA A 1 18  ? -18.365 -4.766  14.129  1.000 22.338  0 18  ALA A C   1 ? 
ATOM   146  O O   . ALA A 1 18  ? -18.933 -5.264  13.140  1.000 28.663  0 18  ALA A O   1 ? 
ATOM   147  C CB  . ALA A 1 18  ? -19.403 -5.329  16.345  1.000 28.627  0 18  ALA A CB  1 ? 
ATOM   148  N N   . GLN A 1 19  ? -17.062 -4.565  14.201  1.000 22.322  0 19  GLN A N   1 ? 
ATOM   149  C CA  . GLN A 1 19  ? -16.076 -4.975  13.196  1.000 21.245  0 19  GLN A CA  1 ? 
ATOM   150  C C   . GLN A 1 19  ? -16.039 -6.507  13.038  1.000 23.367  0 19  GLN A C   1 ? 
ATOM   151  O O   . GLN A 1 19  ? -16.556 -7.259  13.915  1.000 21.670  0 19  GLN A O   1 ? 
ATOM   152  C CB  . GLN A 1 19  ? -14.726 -4.432  13.618  1.000 21.721  0 19  GLN A CB  1 ? 
ATOM   153  C CG  . GLN A 1 19  ? -14.192 -5.107  14.857  1.000 22.892  0 19  GLN A CG  1 ? 
ATOM   154  C CD  . GLN A 1 19  ? -12.799 -4.608  15.131  1.000 25.644  0 19  GLN A CD  1 ? 
ATOM   155  O OE1 . GLN A 1 19  ? -11.930 -4.594  14.267  1.000 25.369  0 19  GLN A OE1 1 ? 
ATOM   156  N NE2 . GLN A 1 19  ? -12.594 -4.147  16.339  1.000 27.504  0 19  GLN A NE2 1 ? 
ATOM   157  N N   . TYR A 1 20  ? -15.397 -6.954  11.968  1.000 24.249  0 20  TYR A N   1 ? 
ATOM   158  C CA  . TYR A 1 20  ? -15.242 -8.383  11.605  1.000 24.749  0 20  TYR A CA  1 ? 
ATOM   159  C C   . TYR A 1 20  ? -14.794 -9.209  12.813  1.000 26.538  0 20  TYR A C   1 ? 
ATOM   160  O O   . TYR A 1 20  ? -15.462 -10.204 13.109  1.000 24.513  0 20  TYR A O   1 ? 
ATOM   161  C CB  . TYR A 1 20  ? -14.212 -8.520  10.499  1.000 27.184  0 20  TYR A CB  1 ? 
ATOM   162  C CG  . TYR A 1 20  ? -14.727 -8.200  9.119   1.000 25.580  0 20  TYR A CG  1 ? 
ATOM   163  C CD1 . TYR A 1 20  ? -15.813 -8.884  8.581   1.000 26.251  0 20  TYR A CD1 1 ? 
ATOM   164  C CD2 . TYR A 1 20  ? -14.048 -7.318  8.310   1.000 27.136  0 20  TYR A CD2 1 ? 
ATOM   165  C CE1 . TYR A 1 20  ? -16.287 -8.603  7.309   1.000 26.832  0 20  TYR A CE1 1 ? 
ATOM   166  C CE2 . TYR A 1 20  ? -14.473 -7.061  7.013   1.000 30.874  0 20  TYR A CE2 1 ? 
ATOM   167  C CZ  . TYR A 1 20  ? -15.595 -7.707  6.507   1.000 31.264  0 20  TYR A CZ  1 ? 
ATOM   168  O OH  . TYR A 1 20  ? -15.981 -7.491  5.207   1.000 36.420  0 20  TYR A OH  1 ? 
ATOM   169  N N   . ASP A 1 21  ? -13.726 -8.788  13.496  1.000 25.822  0 21  ASP A N   1 ? 
ATOM   170  C CA  . ASP A 1 21  ? -13.133 -9.545  14.627  1.000 28.248  0 21  ASP A CA  1 ? 
ATOM   171  C C   . ASP A 1 21  ? -14.143 -9.628  15.775  1.000 27.413  0 21  ASP A C   1 ? 
ATOM   172  O O   . ASP A 1 21  ? -13.919 -10.395 16.661  1.000 32.063  0 21  ASP A O   1 ? 
ATOM   173  C CB  . ASP A 1 21  ? -11.829 -8.907  15.115  1.000 34.256  0 21  ASP A CB  1 ? 
ATOM   174  C CG  . ASP A 1 21  ? -10.669 -9.135  14.162  1.000 37.337  0 21  ASP A CG  1 ? 
ATOM   175  O OD1 . ASP A 1 21  ? -9.647  -8.449  14.318  1.000 46.026  0 21  ASP A OD1 1 ? 
ATOM   176  O OD2 . ASP A 1 21  ? -10.817 -9.964  13.238  1.000 42.599  0 21  ASP A OD2 1 ? 
ATOM   177  N N   . GLU A 1 22  ? -15.214 -8.851  15.776  1.000 26.280  0 22  GLU A N   1 ? 
ATOM   178  C CA  . GLU A 1 22  ? -16.182 -8.913  16.888  1.000 28.234  0 22  GLU A CA  1 ? 
ATOM   179  C C   . GLU A 1 22  ? -17.574 -9.245  16.362  1.000 29.278  0 22  GLU A C   1 ? 
ATOM   180  O O   . GLU A 1 22  ? -18.556 -9.018  17.123  1.000 27.879  0 22  GLU A O   1 ? 
ATOM   181  C CB  . GLU A 1 22  ? -16.238 -7.591  17.650  1.000 30.417  0 22  GLU A CB  1 ? 
ATOM   182  C CG  . GLU A 1 22  ? -14.897 -7.033  18.094  1.000 31.381  0 22  GLU A CG  1 ? 
ATOM   183  C CD  . GLU A 1 22  ? -15.090 -5.745  18.897  1.000 36.194  0 22  GLU A CD  1 ? 
ATOM   184  O OE1 . GLU A 1 22  ? -15.794 -5.792  19.891  1.000 43.359  0 22  GLU A OE1 1 ? 
ATOM   185  O OE2 . GLU A 1 22  ? -14.633 -4.698  18.480  1.000 34.806  0 22  GLU A OE2 1 ? 
ATOM   186  N N   . ASN A 1 23  ? -17.698 -9.683  15.105  1.000 28.276  0 23  ASN A N   1 ? 
ATOM   187  C CA  . ASN A 1 23  ? -19.045 -9.812  14.483  1.000 28.236  0 23  ASN A CA  1 ? 
ATOM   188  C C   . ASN A 1 23  ? -19.131 -11.146 13.720  1.000 32.104  0 23  ASN A C   1 ? 
ATOM   189  O O   . ASN A 1 23  ? -18.711 -11.206 12.549  1.000 25.434  0 23  ASN A O   1 ? 
ATOM   190  C CB  . ASN A 1 23  ? -19.362 -8.603  13.613  1.000 28.812  0 23  ASN A CB  1 ? 
ATOM   191  C CG  . ASN A 1 23  ? -20.843 -8.496  13.293  1.000 28.753  0 23  ASN A CG  1 ? 
ATOM   192  O OD1 . ASN A 1 23  ? -21.544 -9.501  13.109  1.000 26.779  0 23  ASN A OD1 1 ? 
ATOM   193  N ND2 . ASN A 1 23  ? -21.323 -7.274  13.195  1.000 27.738  0 23  ASN A ND2 1 ? 
ATOM   194  N N   . GLN A 1 24  ? -19.646 -12.178 14.389  1.000 31.834  0 24  GLN A N   1 ? 
ATOM   195  C CA  . GLN A 1 24  ? -19.780 -13.549 13.846  1.000 33.665  0 24  GLN A CA  1 ? 
ATOM   196  C C   . GLN A 1 24  ? -20.589 -13.514 12.549  1.000 31.738  0 24  GLN A C   1 ? 
ATOM   197  O O   . GLN A 1 24  ? -20.178 -14.179 11.576  1.000 29.268  0 24  GLN A O   1 ? 
ATOM   198  C CB  . GLN A 1 24  ? -20.486 -14.457 14.845  1.000 39.039  0 24  GLN A CB  1 ? 
ATOM   199  C CG  . GLN A 1 24  ? -20.501 -15.921 14.423  1.000 43.578  0 24  GLN A CG  1 ? 
ATOM   200  C CD  . GLN A 1 24  ? -19.213 -16.582 14.830  1.000 53.651  0 24  GLN A CD  1 ? 
ATOM   201  O OE1 . GLN A 1 24  ? -18.204 -16.515 14.125  1.000 54.722  0 24  GLN A OE1 1 ? 
ATOM   202  N NE2 . GLN A 1 24  ? -19.234 -17.200 16.004  1.000 65.280  0 24  GLN A NE2 1 ? 
ATOM   203  N N   . THR A 1 25  ? -21.725 -12.820 12.556  1.000 30.061  0 25  THR A N   1 ? 
ATOM   204  C CA  . THR A 1 25  ? -22.626 -12.699 11.388  1.000 33.285  0 25  THR A CA  1 ? 
ATOM   205  C C   . THR A 1 25  ? -21.836 -12.200 10.173  1.000 33.415  0 25  THR A C   1 ? 
ATOM   206  O O   . THR A 1 25  ? -21.972 -12.801 9.083   1.000 25.427  0 25  THR A O   1 ? 
ATOM   207  C CB  . THR A 1 25  ? -23.819 -11.806 11.732  1.000 38.076  0 25  THR A CB  1 ? 
ATOM   208  O OG1 . THR A 1 25  ? -24.457 -12.453 12.827  1.000 39.760  0 25  THR A OG1 1 ? 
ATOM   209  C CG2 . THR A 1 25  ? -24.797 -11.646 10.590  1.000 40.651  0 25  THR A CG2 1 ? 
ATOM   210  N N   . LEU A 1 26  ? -21.010 -11.163 10.339  1.000 30.331  0 26  LEU A N   1 ? 
ATOM   211  C CA  . LEU A 1 26  ? -20.280 -10.587 9.192   1.000 29.617  0 26  LEU A CA  1 ? 
ATOM   212  C C   . LEU A 1 26  ? -19.265 -11.603 8.710   1.000 29.499  0 26  LEU A C   1 ? 
ATOM   213  O O   . LEU A 1 26  ? -19.171 -11.777 7.470   1.000 27.581  0 26  LEU A O   1 ? 
ATOM   214  C CB  . LEU A 1 26  ? -19.594 -9.268  9.560   1.000 32.951  0 26  LEU A CB  1 ? 
ATOM   215  C CG  . LEU A 1 26  ? -20.530 -8.116  9.911   1.000 35.863  0 26  LEU A CG  1 ? 
ATOM   216  C CD1 . LEU A 1 26  ? -19.779 -6.781  9.884   1.000 35.814  0 26  LEU A CD1 1 ? 
ATOM   217  C CD2 . LEU A 1 26  ? -21.742 -8.073  8.985   1.000 36.157  0 26  LEU A CD2 1 ? 
ATOM   218  N N   . ARG A 1 27  ? -18.531 -12.244 9.624   1.000 25.062  0 27  ARG A N   1 ? 
ATOM   219  C CA  . ARG A 1 27  ? -17.476 -13.215 9.236   1.000 25.064  0 27  ARG A CA  1 ? 
ATOM   220  C C   . ARG A 1 27  ? -18.114 -14.343 8.432   1.000 24.190  0 27  ARG A C   1 ? 
ATOM   221  O O   . ARG A 1 27  ? -17.562 -14.695 7.357   1.000 24.402  0 27  ARG A O   1 ? 
ATOM   222  C CB  . ARG A 1 27  ? -16.727 -13.759 10.448  1.000 26.229  0 27  ARG A CB  1 ? 
ATOM   223  C CG  . ARG A 1 27  ? -15.850 -12.713 11.114  1.000 29.420  0 27  ARG A CG  1 ? 
ATOM   224  C CD  . ARG A 1 27  ? -14.846 -13.342 12.048  1.000 31.698  0 27  ARG A CD  1 ? 
ATOM   225  N NE  . ARG A 1 27  ? -15.475 -14.194 13.060  1.000 29.484  0 27  ARG A NE  1 ? 
ATOM   226  C CZ  . ARG A 1 27  ? -15.964 -13.774 14.210  1.000 33.276  0 27  ARG A CZ  1 ? 
ATOM   227  N NH1 . ARG A 1 27  ? -15.925 -12.496 14.527  1.000 34.815  0 27  ARG A NH1 1 ? 
ATOM   228  N NH2 . ARG A 1 27  ? -16.468 -14.639 15.074  1.000 36.302  0 27  ARG A NH2 1 ? 
ATOM   229  N N   . ASP A 1 28  ? -19.251 -14.862 8.906   1.000 25.776  0 28  ASP A N   1 ? 
ATOM   230  C CA  . ASP A 1 28  ? -19.974 -15.978 8.242   1.000 27.176  0 28  ASP A CA  1 ? 
ATOM   231  C C   . ASP A 1 28  ? -20.483 -15.511 6.869   1.000 27.672  0 28  ASP A C   1 ? 
ATOM   232  O O   . ASP A 1 28  ? -20.302 -16.256 5.906   1.000 28.077  0 28  ASP A O   1 ? 
ATOM   233  C CB  . ASP A 1 28  ? -21.140 -16.482 9.095   1.000 26.549  0 28  ASP A CB  1 ? 
ATOM   234  C CG  . ASP A 1 28  ? -20.677 -17.183 10.360  1.000 27.959  0 28  ASP A CG  1 ? 
ATOM   235  O OD1 . ASP A 1 28  ? -19.470 -17.523 10.443  1.000 29.303  0 28  ASP A OD1 1 ? 
ATOM   236  O OD2 . ASP A 1 28  ? -21.507 -17.335 11.266  1.000 32.077  0 28  ASP A OD2 1 ? 
ATOM   237  N N   . GLU A 1 29  ? -21.147 -14.357 6.789   1.000 25.036  0 29  GLU A N   1 ? 
ATOM   238  C CA  . GLU A 1 29  ? -21.672 -13.853 5.489   1.000 28.232  0 29  GLU A CA  1 ? 
ATOM   239  C C   . GLU A 1 29  ? -20.497 -13.663 4.508   1.000 29.469  0 29  GLU A C   1 ? 
ATOM   240  O O   . GLU A 1 29  ? -20.637 -14.065 3.319   1.000 30.853  0 29  GLU A O   1 ? 
ATOM   241  C CB  . GLU A 1 29  ? -22.480 -12.571 5.667   1.000 32.039  0 29  GLU A CB  1 ? 
ATOM   242  C CG  . GLU A 1 29  ? -23.797 -12.754 6.416   1.000 32.569  0 29  GLU A CG  1 ? 
ATOM   243  C CD  . GLU A 1 29  ? -24.452 -11.425 6.767   1.000 35.487  0 29  GLU A CD  1 ? 
ATOM   244  O OE1 . GLU A 1 29  ? -23.789 -10.386 6.600   1.000 41.136  0 29  GLU A OE1 1 ? 
ATOM   245  O OE2 . GLU A 1 29  ? -25.612 -11.416 7.204   1.000 35.748  0 29  GLU A OE2 1 ? 
ATOM   246  N N   . ARG A 1 30  ? -19.371 -13.125 4.977   1.000 26.589  0 30  ARG A N   1 ? 
ATOM   247  C CA  . ARG A 1 30  ? -18.142 -12.967 4.173   1.000 27.551  0 30  ARG A CA  1 ? 
ATOM   248  C C   . ARG A 1 30  ? -17.658 -14.345 3.724   1.000 28.632  0 30  ARG A C   1 ? 
ATOM   249  O O   . ARG A 1 30  ? -17.318 -14.509 2.517   1.000 24.897  0 30  ARG A O   1 ? 
ATOM   250  C CB  . ARG A 1 30  ? -17.048 -12.260 4.974   1.000 27.415  0 30  ARG A CB  1 ? 
ATOM   251  C CG  . ARG A 1 30  ? -15.692 -12.234 4.290   1.000 28.267  0 30  ARG A CG  1 ? 
ATOM   252  C CD  . ARG A 1 30  ? -14.579 -11.963 5.263   1.000 30.606  0 30  ARG A CD  1 ? 
ATOM   253  N NE  . ARG A 1 30  ? -14.448 -13.129 6.118   1.000 32.523  0 30  ARG A NE  1 ? 
ATOM   254  C CZ  . ARG A 1 30  ? -13.974 -13.120 7.353   1.000 34.456  0 30  ARG A CZ  1 ? 
ATOM   255  N NH1 . ARG A 1 30  ? -13.539 -11.995 7.901   1.000 35.065  0 30  ARG A NH1 1 ? 
ATOM   256  N NH2 . ARG A 1 30  ? -13.930 -14.247 8.041   1.000 31.954  0 30  ARG A NH2 1 ? 
ATOM   257  N N   . ASP A 1 31  ? -17.544 -15.293 4.656   1.000 28.488  0 31  ASP A N   1 ? 
ATOM   258  C CA  . ASP A 1 31  ? -16.932 -16.621 4.370   1.000 28.501  0 31  ASP A CA  1 ? 
ATOM   259  C C   . ASP A 1 31  ? -17.826 -17.412 3.406   1.000 25.458  0 31  ASP A C   1 ? 
ATOM   260  O O   . ASP A 1 31  ? -17.259 -18.105 2.540   1.000 27.647  0 31  ASP A O   1 ? 
ATOM   261  C CB  . ASP A 1 31  ? -16.649 -17.379 5.662   1.000 32.022  0 31  ASP A CB  1 ? 
ATOM   262  C CG  . ASP A 1 31  ? -15.488 -16.782 6.422   1.000 37.616  0 31  ASP A CG  1 ? 
ATOM   263  O OD1 . ASP A 1 31  ? -14.744 -15.995 5.812   1.000 37.013  0 31  ASP A OD1 1 ? 
ATOM   264  O OD2 . ASP A 1 31  ? -15.301 -17.154 7.595   1.000 41.652  0 31  ASP A OD2 1 ? 
ATOM   265  N N   . ALA A 1 32  ? -19.148 -17.225 3.488   1.000 26.571  0 32  ALA A N   1 ? 
ATOM   266  C CA  . ALA A 1 32  ? -20.152 -17.848 2.596   1.000 29.580  0 32  ALA A CA  1 ? 
ATOM   267  C C   . ALA A 1 32  ? -19.884 -17.430 1.144   1.000 33.888  0 32  ALA A C   1 ? 
ATOM   268  O O   . ALA A 1 32  ? -19.874 -18.329 0.271   1.000 38.663  0 32  ALA A O   1 ? 
ATOM   269  C CB  . ALA A 1 32  ? -21.556 -17.508 3.038   1.000 32.042  0 32  ALA A CB  1 ? 
ATOM   270  N N   . VAL A 1 33  ? -19.593 -16.142 0.896   1.000 33.006  0 33  VAL A N   1 ? 
ATOM   271  C CA  . VAL A 1 33  ? -19.272 -15.637 -0.468  1.000 28.771  0 33  VAL A CA  1 ? 
ATOM   272  C C   . VAL A 1 33  ? -17.887 -16.128 -0.889  1.000 25.994  0 33  VAL A C   1 ? 
ATOM   273  O O   . VAL A 1 33  ? -17.771 -16.542 -2.037  1.000 31.731  0 33  VAL A O   1 ? 
ATOM   274  C CB  . VAL A 1 33  ? -19.414 -14.117 -0.609  1.000 32.818  0 33  VAL A CB  1 ? 
ATOM   275  C CG1 . VAL A 1 33  ? -18.992 -13.622 -1.995  1.000 31.138  0 33  VAL A CG1 1 ? 
ATOM   276  C CG2 . VAL A 1 33  ? -20.825 -13.690 -0.326  1.000 37.520  0 33  VAL A CG2 1 ? 
ATOM   277  N N   . LEU A 1 34  ? -16.881 -16.144 -0.028  1.000 24.907  0 34  LEU A N   1 ? 
ATOM   278  C CA  . LEU A 1 34  ? -15.557 -16.650 -0.436  1.000 25.997  0 34  LEU A CA  1 ? 
ATOM   279  C C   . LEU A 1 34  ? -15.695 -18.138 -0.826  1.000 32.168  0 34  LEU A C   1 ? 
ATOM   280  O O   . LEU A 1 34  ? -15.031 -18.571 -1.782  1.000 28.016  0 34  LEU A O   1 ? 
ATOM   281  C CB  . LEU A 1 34  ? -14.547 -16.449 0.686   1.000 25.944  0 34  LEU A CB  1 ? 
ATOM   282  C CG  . LEU A 1 34  ? -14.253 -14.991 1.039   1.000 27.828  0 34  LEU A CG  1 ? 
ATOM   283  C CD1 . LEU A 1 34  ? -13.186 -14.910 2.111   1.000 28.483  0 34  LEU A CD1 1 ? 
ATOM   284  C CD2 . LEU A 1 34  ? -13.805 -14.201 -0.192  1.000 30.304  0 34  LEU A CD2 1 ? 
ATOM   285  N N   . THR A 1 35  ? -16.454 -18.932 -0.054  1.000 33.546  0 35  THR A N   1 ? 
ATOM   286  C CA  . THR A 1 35  ? -16.626 -20.371 -0.359  1.000 32.142  0 35  THR A CA  1 ? 
ATOM   287  C C   . THR A 1 35  ? -17.328 -20.482 -1.716  1.000 29.505  0 35  THR A C   1 ? 
ATOM   288  O O   . THR A 1 35  ? -16.834 -21.241 -2.530  1.000 29.324  0 35  THR A O   1 ? 
ATOM   289  C CB  . THR A 1 35  ? -17.312 -21.127 0.786   1.000 31.003  0 35  THR A CB  1 ? 
ATOM   290  O OG1 . THR A 1 35  ? -16.341 -21.109 1.830   1.000 28.621  0 35  THR A OG1 1 ? 
ATOM   291  C CG2 . THR A 1 35  ? -17.680 -22.544 0.416   1.000 29.637  0 35  THR A CG2 1 ? 
ATOM   292  N N   . ALA A 1 36  ? -18.356 -19.668 -1.975  1.000 27.419  0 36  ALA A N   1 ? 
ATOM   293  C CA  . ALA A 1 36  ? -19.074 -19.633 -3.274  1.000 28.432  0 36  ALA A CA  1 ? 
ATOM   294  C C   . ALA A 1 36  ? -18.116 -19.296 -4.408  1.000 29.411  0 36  ALA A C   1 ? 
ATOM   295  O O   . ALA A 1 36  ? -18.245 -19.895 -5.512  1.000 32.175  0 36  ALA A O   1 ? 
ATOM   296  C CB  . ALA A 1 36  ? -20.210 -18.659 -3.229  1.000 32.767  0 36  ALA A CB  1 ? 
ATOM   297  N N   . VAL A 1 37  ? -17.197 -18.360 -4.186  1.000 30.392  0 37  VAL A N   1 ? 
ATOM   298  C CA  . VAL A 1 37  ? -16.182 -17.996 -5.219  1.000 32.348  0 37  VAL A CA  1 ? 
ATOM   299  C C   . VAL A 1 37  ? -15.303 -19.213 -5.468  1.000 36.628  0 37  VAL A C   1 ? 
ATOM   300  O O   . VAL A 1 37  ? -15.075 -19.551 -6.647  1.000 32.318  0 37  VAL A O   1 ? 
ATOM   301  C CB  . VAL A 1 37  ? -15.332 -16.788 -4.803  1.000 29.517  0 37  VAL A CB  1 ? 
ATOM   302  C CG1 . VAL A 1 37  ? -14.154 -16.623 -5.737  1.000 30.837  0 37  VAL A CG1 1 ? 
ATOM   303  C CG2 . VAL A 1 37  ? -16.180 -15.537 -4.761  1.000 33.029  0 37  VAL A CG2 1 ? 
ATOM   304  N N   . ARG A 1 38  ? -14.780 -19.782 -4.382  1.000 39.229  0 38  ARG A N   1 ? 
ATOM   305  C CA  . ARG A 1 38  ? -13.825 -20.919 -4.370  1.000 41.146  0 38  ARG A CA  1 ? 
ATOM   306  C C   . ARG A 1 38  ? -14.422 -22.088 -5.187  1.000 38.234  0 38  ARG A C   1 ? 
ATOM   307  O O   . ARG A 1 38  ? -13.711 -22.682 -5.987  1.000 38.430  0 38  ARG A O   1 ? 
ATOM   308  C CB  . ARG A 1 38  ? -13.585 -21.303 -2.905  1.000 51.029  0 38  ARG A CB  1 ? 
ATOM   309  C CG  . ARG A 1 38  ? -12.140 -21.273 -2.424  1.000 60.706  0 38  ARG A CG  1 ? 
ATOM   310  C CD  . ARG A 1 38  ? -11.872 -22.423 -1.456  1.000 69.046  0 38  ARG A CD  1 ? 
ATOM   311  N NE  . ARG A 1 38  ? -11.933 -23.697 -2.197  1.000 81.058  0 38  ARG A NE  1 ? 
ATOM   312  C CZ  . ARG A 1 38  ? -11.472 -24.893 -1.790  1.000 69.727  0 38  ARG A CZ  1 ? 
ATOM   313  N NH1 . ARG A 1 38  ? -11.596 -25.940 -2.592  1.000 68.482  0 38  ARG A NH1 1 ? 
ATOM   314  N NH2 . ARG A 1 38  ? -10.902 -25.046 -0.605  1.000 63.668  0 38  ARG A NH2 1 ? 
ATOM   315  N N   . GLU A 1 39  ? -15.702 -22.385 -4.980  1.000 40.408  0 39  GLU A N   1 ? 
ATOM   316  C CA  . GLU A 1 39  ? -16.389 -23.570 -5.561  1.000 48.436  0 39  GLU A CA  1 ? 
ATOM   317  C C   . GLU A 1 39  ? -16.812 -23.217 -6.993  1.000 45.470  0 39  GLU A C   1 ? 
ATOM   318  O O   . GLU A 1 39  ? -16.563 -24.033 -7.883  1.000 46.449  0 39  GLU A O   1 ? 
ATOM   319  C CB  . GLU A 1 39  ? -17.556 -24.044 -4.674  1.000 50.006  0 39  GLU A CB  1 ? 
ATOM   320  C CG  . GLU A 1 39  ? -17.143 -24.696 -3.329  1.000 52.733  0 39  GLU A CG  1 ? 
ATOM   321  C CD  . GLU A 1 39  ? -15.886 -25.586 -3.282  1.000 60.065  0 39  GLU A CD  1 ? 
ATOM   322  O OE1 . GLU A 1 39  ? -15.756 -26.518 -4.117  1.000 67.952  0 39  GLU A OE1 1 ? 
ATOM   323  O OE2 . GLU A 1 39  ? -15.032 -25.359 -2.399  1.000 60.565  0 39  GLU A OE2 1 ? 
ATOM   324  N N   . GLY A 1 40  ? -17.384 -22.024 -7.196  1.000 42.735  0 40  GLY A N   1 ? 
ATOM   325  C CA  . GLY A 1 40  ? -17.715 -21.451 -8.516  1.000 34.882  0 40  GLY A CA  1 ? 
ATOM   326  C C   . GLY A 1 40  ? -16.539 -21.494 -9.472  1.000 36.490  0 40  GLY A C   1 ? 
ATOM   327  O O   . GLY A 1 40  ? -16.760 -21.868 -10.665 1.000 36.102  0 40  GLY A O   1 ? 
ATOM   328  N N   . LEU A 1 41  ? -15.329 -21.158 -9.009  1.000 31.627  0 41  LEU A N   1 ? 
ATOM   329  C CA  . LEU A 1 41  ? -14.134 -21.116 -9.897  1.000 35.587  0 41  LEU A CA  1 ? 
ATOM   330  C C   . LEU A 1 41  ? -13.835 -22.531 -10.386 1.000 38.626  0 41  LEU A C   1 ? 
ATOM   331  O O   . LEU A 1 41  ? -13.532 -22.723 -11.596 1.000 35.718  0 41  LEU A O   1 ? 
ATOM   332  C CB  . LEU A 1 41  ? -12.925 -20.536 -9.162  1.000 35.742  0 41  LEU A CB  1 ? 
ATOM   333  C CG  . LEU A 1 41  ? -12.876 -19.010 -9.042  1.000 35.011  0 41  LEU A CG  1 ? 
ATOM   334  C CD1 . LEU A 1 41  ? -11.734 -18.594 -8.129  1.000 31.859  0 41  LEU A CD1 1 ? 
ATOM   335  C CD2 . LEU A 1 41  ? -12.724 -18.348 -10.409 1.000 35.584  0 41  LEU A CD2 1 ? 
ATOM   336  N N   . LYS A 1 42  ? -13.860 -23.475 -9.462  1.000 39.227  0 42  LYS A N   1 ? 
ATOM   337  C CA  . LYS A 1 42  ? -13.724 -24.930 -9.733  1.000 44.715  0 42  LYS A CA  1 ? 
ATOM   338  C C   . LYS A 1 42  ? -14.616 -25.336 -10.922 1.000 35.499  0 42  LYS A C   1 ? 
ATOM   339  O O   . LYS A 1 42  ? -14.100 -25.936 -11.849 1.000 39.857  0 42  LYS A O   1 ? 
ATOM   340  C CB  . LYS A 1 42  ? -14.088 -25.675 -8.446  1.000 54.883  0 42  LYS A CB  1 ? 
ATOM   341  C CG  . LYS A 1 42  ? -13.368 -26.992 -8.219  1.000 66.919  0 42  LYS A CG  1 ? 
ATOM   342  C CD  . LYS A 1 42  ? -14.220 -28.001 -7.456  1.000 71.116  0 42  LYS A CD  1 ? 
ATOM   343  C CE  . LYS A 1 42  ? -14.335 -29.325 -8.186  1.000 77.634  0 42  LYS A CE  1 ? 
ATOM   344  N NZ  . LYS A 1 42  ? -14.374 -30.461 -7.241  1.000 78.692  0 42  LYS A NZ  1 ? 
ATOM   345  N N   . LYS A 1 43  ? -15.908 -25.023 -10.901 1.000 39.660  0 43  LYS A N   1 ? 
ATOM   346  C CA  . LYS A 1 43  ? -16.853 -25.448 -11.970 1.000 45.850  0 43  LYS A CA  1 ? 
ATOM   347  C C   . LYS A 1 43  ? -16.574 -24.673 -13.262 1.000 47.145  0 43  LYS A C   1 ? 
ATOM   348  O O   . LYS A 1 43  ? -16.644 -25.298 -14.343 1.000 43.292  0 43  LYS A O   1 ? 
ATOM   349  C CB  . LYS A 1 43  ? -18.317 -25.225 -11.587 1.000 57.745  0 43  LYS A CB  1 ? 
ATOM   350  C CG  . LYS A 1 43  ? -19.304 -25.504 -12.716 1.000 66.958  0 43  LYS A CG  1 ? 
ATOM   351  C CD  . LYS A 1 43  ? -20.746 -25.454 -12.293 1.000 76.651  0 43  LYS A CD  1 ? 
ATOM   352  C CE  . LYS A 1 43  ? -21.385 -24.109 -12.572 1.000 85.534  0 43  LYS A CE  1 ? 
ATOM   353  N NZ  . LYS A 1 43  ? -22.791 -24.072 -12.105 1.000 90.234  0 43  LYS A NZ  1 ? 
ATOM   354  N N   . VAL A 1 44  ? -16.321 -23.359 -13.166 1.000 44.203  0 44  VAL A N   1 ? 
ATOM   355  C CA  . VAL A 1 44  ? -16.085 -22.470 -14.349 1.000 42.869  0 44  VAL A CA  1 ? 
ATOM   356  C C   . VAL A 1 44  ? -14.872 -22.993 -15.113 1.000 40.168  0 44  VAL A C   1 ? 
ATOM   357  O O   . VAL A 1 44  ? -14.967 -23.141 -16.345 1.000 40.428  0 44  VAL A O   1 ? 
ATOM   358  C CB  . VAL A 1 44  ? -15.875 -20.999 -13.953 1.000 40.732  0 44  VAL A CB  1 ? 
ATOM   359  C CG1 . VAL A 1 44  ? -15.353 -20.170 -15.130 1.000 41.344  0 44  VAL A CG1 1 ? 
ATOM   360  C CG2 . VAL A 1 44  ? -17.146 -20.395 -13.384 1.000 42.343  0 44  VAL A CG2 1 ? 
ATOM   361  N N   . PHE A 1 45  ? -13.775 -23.238 -14.409 1.000 35.837  0 45  PHE A N   1 ? 
ATOM   362  C CA  . PHE A 1 45  ? -12.498 -23.678 -15.020 1.000 38.432  0 45  PHE A CA  1 ? 
ATOM   363  C C   . PHE A 1 45  ? -12.528 -25.187 -15.334 1.000 43.787  0 45  PHE A C   1 ? 
ATOM   364  O O   . PHE A 1 45  ? -11.879 -25.569 -16.331 1.000 44.387  0 45  PHE A O   1 ? 
ATOM   365  C CB  . PHE A 1 45  ? -11.326 -23.250 -14.145 1.000 35.812  0 45  PHE A CB  1 ? 
ATOM   366  C CG  . PHE A 1 45  ? -10.966 -21.800 -14.354 1.000 40.513  0 45  PHE A CG  1 ? 
ATOM   367  C CD1 . PHE A 1 45  ? -11.803 -20.793 -13.894 1.000 39.758  0 45  PHE A CD1 1 ? 
ATOM   368  C CD2 . PHE A 1 45  ? -9.858  -21.443 -15.115 1.000 40.776  0 45  PHE A CD2 1 ? 
ATOM   369  C CE1 . PHE A 1 45  ? -11.496 -19.457 -14.128 1.000 39.703  0 45  PHE A CE1 1 ? 
ATOM   370  C CE2 . PHE A 1 45  ? -9.543  -20.109 -15.330 1.000 39.600  0 45  PHE A CE2 1 ? 
ATOM   371  C CZ  . PHE A 1 45  ? -10.364 -19.120 -14.839 1.000 36.633  0 45  PHE A CZ  1 ? 
ATOM   372  N N   . ALA A 1 46  ? -13.240 -26.019 -14.556 1.000 41.106  0 46  ALA A N   1 ? 
ATOM   373  C CA  . ALA A 1 46  ? -13.367 -27.474 -14.853 1.000 49.007  0 46  ALA A CA  1 ? 
ATOM   374  C C   . ALA A 1 46  ? -13.920 -27.620 -16.271 1.000 51.817  0 46  ALA A C   1 ? 
ATOM   375  O O   . ALA A 1 46  ? -13.215 -28.174 -17.125 1.000 49.141  0 46  ALA A O   1 ? 
ATOM   376  C CB  . ALA A 1 46  ? -14.265 -28.180 -13.859 1.000 51.466  0 46  ALA A CB  1 ? 
ATOM   377  N N   . ASP A 1 47  ? -15.103 -27.036 -16.491 1.000 54.449  0 47  ASP A N   1 ? 
ATOM   378  C CA  . ASP A 1 47  ? -15.918 -27.098 -17.730 1.000 56.901  0 47  ASP A CA  1 ? 
ATOM   379  C C   . ASP A 1 47  ? -15.127 -26.529 -18.918 1.000 60.471  0 47  ASP A C   1 ? 
ATOM   380  O O   . ASP A 1 47  ? -15.511 -26.855 -20.041 1.000 54.168  0 47  ASP A O   1 ? 
ATOM   381  C CB  . ASP A 1 47  ? -17.248 -26.361 -17.541 1.000 58.700  0 47  ASP A CB  1 ? 
ATOM   382  C CG  . ASP A 1 47  ? -18.046 -26.828 -16.328 1.000 66.292  0 47  ASP A CG  1 ? 
ATOM   383  O OD1 . ASP A 1 47  ? -17.549 -27.716 -15.593 1.000 75.365  0 47  ASP A OD1 1 ? 
ATOM   384  O OD2 . ASP A 1 47  ? -19.141 -26.279 -16.097 1.000 66.381  0 47  ASP A OD2 1 ? 
ATOM   385  N N   . ARG A 1 48  ? -14.071 -25.731 -18.679 1.000 57.249  0 48  ARG A N   1 ? 
ATOM   386  C CA  . ARG A 1 48  ? -13.088 -25.287 -19.715 1.000 58.089  0 48  ARG A CA  1 ? 
ATOM   387  C C   . ARG A 1 48  ? -11.902 -26.250 -19.784 1.000 53.677  0 48  ARG A C   1 ? 
ATOM   388  O O   . ARG A 1 48  ? -10.941 -25.937 -20.497 1.000 53.376  0 48  ARG A O   1 ? 
ATOM   389  C CB  . ARG A 1 48  ? -12.493 -23.909 -19.410 1.000 58.406  0 48  ARG A CB  1 ? 
ATOM   390  C CG  . ARG A 1 48  ? -13.443 -22.745 -19.612 1.000 58.469  0 48  ARG A CG  1 ? 
ATOM   391  C CD  . ARG A 1 48  ? -12.864 -21.498 -18.968 1.000 57.629  0 48  ARG A CD  1 ? 
ATOM   392  N NE  . ARG A 1 48  ? -13.856 -20.445 -19.014 1.000 58.836  0 48  ARG A NE  1 ? 
ATOM   393  C CZ  . ARG A 1 48  ? -13.801 -19.312 -18.333 1.000 54.002  0 48  ARG A CZ  1 ? 
ATOM   394  N NH1 . ARG A 1 48  ? -12.773 -19.050 -17.546 1.000 52.995  0 48  ARG A NH1 1 ? 
ATOM   395  N NH2 . ARG A 1 48  ? -14.783 -18.438 -18.450 1.000 58.002  0 48  ARG A NH2 1 ? 
ATOM   396  N N   . GLY A 1 49  ? -11.927 -27.327 -19.008 1.000 59.954  0 49  GLY A N   1 ? 
ATOM   397  C CA  . GLY A 1 49  ? -10.787 -28.256 -18.860 1.000 63.180  0 49  GLY A CA  1 ? 
ATOM   398  C C   . GLY A 1 49  ? -9.515  -27.549 -18.425 1.000 63.968  0 49  GLY A C   1 ? 
ATOM   399  O O   . GLY A 1 49  ? -8.433  -28.085 -18.697 1.000 60.656  0 49  GLY A O   1 ? 
ATOM   400  N N   . GLU A 1 50  ? -9.635  -26.401 -17.750 1.000 71.627  0 50  GLU A N   1 ? 
ATOM   401  C CA  . GLU A 1 50  ? -8.481  -25.601 -17.244 1.000 76.927  0 50  GLU A CA  1 ? 
ATOM   402  C C   . GLU A 1 50  ? -8.414  -25.713 -15.716 1.000 64.625  0 50  GLU A C   1 ? 
ATOM   403  O O   . GLU A 1 50  ? -9.463  -26.053 -15.073 1.000 52.257  0 50  GLU A O   1 ? 
ATOM   404  C CB  . GLU A 1 50  ? -8.570  -24.115 -17.645 1.000 81.192  0 50  GLU A CB  1 ? 
ATOM   405  C CG  . GLU A 1 50  ? -8.765  -23.877 -19.124 1.000 85.750  0 50  GLU A CG  1 ? 
ATOM   406  C CD  . GLU A 1 50  ? -7.674  -24.492 -19.975 1.000 98.895  0 50  GLU A CD  1 ? 
ATOM   407  O OE1 . GLU A 1 50  ? -7.912  -24.693 -21.175 1.000 109.902 0 50  GLU A OE1 1 ? 
ATOM   408  O OE2 . GLU A 1 50  ? -6.587  -24.769 -19.429 1.000 100.959 0 50  GLU A OE2 1 ? 
ATOM   409  N N   . ALA A 1 51  ? -7.231  -25.421 -15.164 1.000 59.148  0 51  ALA A N   1 ? 
ATOM   410  C CA  . ALA A 1 51  ? -6.967  -25.341 -13.710 1.000 60.611  0 51  ALA A CA  1 ? 
ATOM   411  C C   . ALA A 1 51  ? -7.652  -24.088 -13.138 1.000 50.746  0 51  ALA A C   1 ? 
ATOM   412  O O   . ALA A 1 51  ? -7.530  -23.011 -13.734 1.000 47.775  0 51  ALA A O   1 ? 
ATOM   413  C CB  . ALA A 1 51  ? -5.471  -25.344 -13.447 1.000 63.228  0 51  ALA A CB  1 ? 
ATOM   414  N N   . ALA A 1 52  ? -8.387  -24.238 -12.042 1.000 47.257  0 52  ALA A N   1 ? 
ATOM   415  C CA  . ALA A 1 52  ? -9.018  -23.114 -11.318 1.000 44.086  0 52  ALA A CA  1 ? 
ATOM   416  C C   . ALA A 1 52  ? -7.921  -22.258 -10.676 1.000 41.664  0 52  ALA A C   1 ? 
ATOM   417  O O   . ALA A 1 52  ? -6.975  -22.774 -10.086 1.000 38.663  0 52  ALA A O   1 ? 
ATOM   418  C CB  . ALA A 1 52  ? -10.025 -23.631 -10.319 1.000 44.765  0 52  ALA A CB  1 ? 
ATOM   419  N N   . PRO A 1 53  ? -7.973  -20.912 -10.827 1.000 44.656  0 53  PRO A N   1 ? 
ATOM   420  C CA  . PRO A 1 53  ? -7.065  -20.010 -10.102 1.000 42.141  0 53  PRO A CA  1 ? 
ATOM   421  C C   . PRO A 1 53  ? -7.489  -19.931 -8.630  1.000 32.800  0 53  PRO A C   1 ? 
ATOM   422  O O   . PRO A 1 53  ? -8.640  -20.105 -8.363  1.000 33.343  0 53  PRO A O   1 ? 
ATOM   423  C CB  . PRO A 1 53  ? -7.291  -18.652 -10.784 1.000 42.421  0 53  PRO A CB  1 ? 
ATOM   424  C CG  . PRO A 1 53  ? -8.763  -18.719 -11.214 1.000 46.557  0 53  PRO A CG  1 ? 
ATOM   425  C CD  . PRO A 1 53  ? -8.989  -20.173 -11.608 1.000 47.872  0 53  PRO A CD  1 ? 
ATOM   426  N N   . THR A 1 54  ? -6.548  -19.750 -7.716  1.000 34.687  0 54  THR A N   1 ? 
ATOM   427  C CA  . THR A 1 54  ? -6.831  -19.648 -6.256  1.000 35.051  0 54  THR A CA  1 ? 
ATOM   428  C C   . THR A 1 54  ? -6.579  -18.216 -5.798  1.000 33.594  0 54  THR A C   1 ? 
ATOM   429  O O   . THR A 1 54  ? -5.955  -17.431 -6.581  1.000 31.671  0 54  THR A O   1 ? 
ATOM   430  C CB  . THR A 1 54  ? -5.942  -20.593 -5.461  1.000 36.645  0 54  THR A CB  1 ? 
ATOM   431  O OG1 . THR A 1 54  ? -4.644  -20.300 -5.977  1.000 33.750  0 54  THR A OG1 1 ? 
ATOM   432  C CG2 . THR A 1 54  ? -6.351  -22.045 -5.640  1.000 41.287  0 54  THR A CG2 1 ? 
ATOM   433  N N   . PHE A 1 55  ? -6.984  -17.904 -4.575  1.000 34.295  0 55  PHE A N   1 ? 
ATOM   434  C CA  . PHE A 1 55  ? -6.885  -16.534 -4.035  1.000 32.428  0 55  PHE A CA  1 ? 
ATOM   435  C C   . PHE A 1 55  ? -6.691  -16.590 -2.531  1.000 35.374  0 55  PHE A C   1 ? 
ATOM   436  O O   . PHE A 1 55  ? -7.079  -17.584 -1.932  1.000 31.455  0 55  PHE A O   1 ? 
ATOM   437  C CB  . PHE A 1 55  ? -8.146  -15.770 -4.407  1.000 30.538  0 55  PHE A CB  1 ? 
ATOM   438  C CG  . PHE A 1 55  ? -9.387  -16.272 -3.729  1.000 29.631  0 55  PHE A CG  1 ? 
ATOM   439  C CD1 . PHE A 1 55  ? -9.670  -15.911 -2.421  1.000 27.279  0 55  PHE A CD1 1 ? 
ATOM   440  C CD2 . PHE A 1 55  ? -10.296 -17.063 -4.409  1.000 30.847  0 55  PHE A CD2 1 ? 
ATOM   441  C CE1 . PHE A 1 55  ? -10.850 -16.316 -1.811  1.000 27.343  0 55  PHE A CE1 1 ? 
ATOM   442  C CE2 . PHE A 1 55  ? -11.454 -17.503 -3.788  1.000 31.110  0 55  PHE A CE2 1 ? 
ATOM   443  C CZ  . PHE A 1 55  ? -11.739 -17.115 -2.495  1.000 31.963  0 55  PHE A CZ  1 ? 
ATOM   444  N N   . THR A 1 56  ? -6.112  -15.529 -1.974  1.000 34.414  0 56  THR A N   1 ? 
ATOM   445  C CA  . THR A 1 56  ? -5.992  -15.250 -0.520  1.000 30.074  0 56  THR A CA  1 ? 
ATOM   446  C C   . THR A 1 56  ? -6.846  -14.044 -0.205  1.000 29.166  0 56  THR A C   1 ? 
ATOM   447  O O   . THR A 1 56  ? -6.661  -13.000 -0.816  1.000 30.741  0 56  THR A O   1 ? 
ATOM   448  C CB  . THR A 1 56  ? -4.574  -14.852 -0.151  1.000 30.372  0 56  THR A CB  1 ? 
ATOM   449  O OG1 . THR A 1 56  ? -3.788  -15.854 -0.772  1.000 37.225  0 56  THR A OG1 1 ? 
ATOM   450  C CG2 . THR A 1 56  ? -4.334  -14.757 1.341   1.000 37.118  0 56  THR A CG2 1 ? 
ATOM   451  N N   . PRO A 1 57  ? -7.831  -14.167 0.688   1.000 25.067  0 57  PRO A N   1 ? 
ATOM   452  C CA  . PRO A 1 57  ? -8.692  -13.046 1.024   1.000 22.802  0 57  PRO A CA  1 ? 
ATOM   453  C C   . PRO A 1 57  ? -8.051  -12.163 2.100   1.000 24.237  0 57  PRO A C   1 ? 
ATOM   454  O O   . PRO A 1 57  ? -7.179  -12.630 2.781   1.000 24.661  0 57  PRO A O   1 ? 
ATOM   455  C CB  . PRO A 1 57  ? -9.939  -13.745 1.567   1.000 24.660  0 57  PRO A CB  1 ? 
ATOM   456  C CG  . PRO A 1 57  ? -9.355  -14.969 2.276   1.000 25.113  0 57  PRO A CG  1 ? 
ATOM   457  C CD  . PRO A 1 57  ? -8.216  -15.419 1.372   1.000 26.059  0 57  PRO A CD  1 ? 
ATOM   458  N N   . PHE A 1 58  ? -8.482  -10.918 2.216   1.000 21.771  0 58  PHE A N   1 ? 
ATOM   459  C CA  . PHE A 1 58  ? -8.146  -10.058 3.375   1.000 22.242  0 58  PHE A CA  1 ? 
ATOM   460  C C   . PHE A 1 58  ? -9.293  -9.093  3.565   1.000 23.082  0 58  PHE A C   1 ? 
ATOM   461  O O   . PHE A 1 58  ? -9.994  -8.772  2.568   1.000 21.576  0 58  PHE A O   1 ? 
ATOM   462  C CB  . PHE A 1 58  ? -6.779  -9.388  3.211   1.000 25.085  0 58  PHE A CB  1 ? 
ATOM   463  C CG  . PHE A 1 58  ? -6.690  -8.368  2.103   1.000 23.044  0 58  PHE A CG  1 ? 
ATOM   464  C CD1 . PHE A 1 58  ? -6.331  -8.746  0.821   1.000 22.668  0 58  PHE A CD1 1 ? 
ATOM   465  C CD2 . PHE A 1 58  ? -6.924  -7.031  2.349   1.000 23.932  0 58  PHE A CD2 1 ? 
ATOM   466  C CE1 . PHE A 1 58  ? -6.240  -7.814  -0.203  1.000 23.810  0 58  PHE A CE1 1 ? 
ATOM   467  C CE2 . PHE A 1 58  ? -6.818  -6.094  1.336   1.000 25.278  0 58  PHE A CE2 1 ? 
ATOM   468  C CZ  . PHE A 1 58  ? -6.494  -6.492  0.048   1.000 24.349  0 58  PHE A CZ  1 ? 
ATOM   469  N N   . ASN A 1 59  ? -9.562  -8.762  4.821   1.000 20.370  0 59  ASN A N   1 ? 
ATOM   470  C CA  . ASN A 1 59  ? -10.639 -7.833  5.214   1.000 21.338  0 59  ASN A CA  1 ? 
ATOM   471  C C   . ASN A 1 59  ? -10.296 -6.413  4.731   1.000 22.593  0 59  ASN A C   1 ? 
ATOM   472  O O   . ASN A 1 59  ? -9.153  -5.975  4.878   1.000 23.153  0 59  ASN A O   1 ? 
ATOM   473  C CB  . ASN A 1 59  ? -10.844 -7.876  6.729   1.000 25.803  0 59  ASN A CB  1 ? 
ATOM   474  C CG  . ASN A 1 59  ? -11.370 -9.217  7.199   1.000 25.198  0 59  ASN A CG  1 ? 
ATOM   475  O OD1 . ASN A 1 59  ? -11.930 -9.971  6.417   1.000 28.235  0 59  ASN A OD1 1 ? 
ATOM   476  N ND2 . ASN A 1 59  ? -11.170 -9.527  8.467   1.000 29.894  0 59  ASN A ND2 1 ? 
ATOM   477  N N   . GLN A 1 60  ? -11.278 -5.710  4.204   1.000 23.373  0 60  GLN A N   1 ? 
ATOM   478  C CA  . GLN A 1 60  ? -11.146 -4.305  3.801   1.000 26.592  0 60  GLN A CA  1 ? 
ATOM   479  C C   . GLN A 1 60  ? -12.312 -3.520  4.360   1.000 24.140  0 60  GLN A C   1 ? 
ATOM   480  O O   . GLN A 1 60  ? -13.282 -4.149  4.778   1.000 27.240  0 60  GLN A O   1 ? 
ATOM   481  C CB  . GLN A 1 60  ? -11.251 -4.167  2.284   1.000 30.186  0 60  GLN A CB  1 ? 
ATOM   482  C CG  . GLN A 1 60  ? -10.022 -4.585  1.567   1.000 34.236  0 60  GLN A CG  1 ? 
ATOM   483  C CD  . GLN A 1 60  ? -10.179 -4.379  0.084   1.000 32.151  0 60  GLN A CD  1 ? 
ATOM   484  O OE1 . GLN A 1 60  ? -11.213 -3.969  -0.407  1.000 33.136  0 60  GLN A OE1 1 ? 
ATOM   485  N NE2 . GLN A 1 60  ? -9.119  -4.647  -0.633  1.000 33.977  0 60  GLN A NE2 1 ? 
ATOM   486  N N   . GLY A 1 61  ? -12.215 -2.191  4.270   1.000 24.630  0 61  GLY A N   1 ? 
ATOM   487  C CA  . GLY A 1 61  ? -13.340 -1.263  4.444   1.000 24.311  0 61  GLY A CA  1 ? 
ATOM   488  C C   . GLY A 1 61  ? -13.706 -1.123  5.904   1.000 22.942  0 61  GLY A C   1 ? 
ATOM   489  O O   . GLY A 1 61  ? -12.876 -1.463  6.749   1.000 19.750  0 61  GLY A O   1 ? 
ATOM   490  N N   . SER A 1 62  ? -14.935 -0.697  6.175   1.000 21.638  0 62  SER A N   1 ? 
ATOM   491  C CA  . SER A 1 62  ? -15.339 -0.150  7.483   1.000 22.634  0 62  SER A CA  1 ? 
ATOM   492  C C   . SER A 1 62  ? -15.312 -1.257  8.551   1.000 22.316  0 62  SER A C   1 ? 
ATOM   493  O O   . SER A 1 62  ? -14.870 -0.973  9.672   1.000 20.766  0 62  SER A O   1 ? 
ATOM   494  C CB  . SER A 1 62  ? -16.641 0.549   7.365   1.000 26.032  0 62  SER A CB  1 ? 
ATOM   495  O OG  . SER A 1 62  ? -17.685 -0.335  7.059   1.000 31.903  0 62  SER A OG  1 ? 
ATOM   496  N N   . TYR A 1 63  ? -15.610 -2.496  8.190   1.000 22.254  0 63  TYR A N   1 ? 
ATOM   497  C CA  . TYR A 1 63  ? -15.669 -3.642  9.132   1.000 23.314  0 63  TYR A CA  1 ? 
ATOM   498  C C   . TYR A 1 63  ? -14.261 -4.162  9.399   1.000 23.952  0 63  TYR A C   1 ? 
ATOM   499  O O   . TYR A 1 63  ? -14.068 -4.894  10.410  1.000 24.314  0 63  TYR A O   1 ? 
ATOM   500  C CB  . TYR A 1 63  ? -16.676 -4.680  8.628   1.000 23.450  0 63  TYR A CB  1 ? 
ATOM   501  C CG  . TYR A 1 63  ? -18.010 -4.026  8.434   1.000 24.928  0 63  TYR A CG  1 ? 
ATOM   502  C CD1 . TYR A 1 63  ? -18.641 -3.450  9.505   1.000 26.342  0 63  TYR A CD1 1 ? 
ATOM   503  C CD2 . TYR A 1 63  ? -18.568 -3.858  7.188   1.000 27.379  0 63  TYR A CD2 1 ? 
ATOM   504  C CE1 . TYR A 1 63  ? -19.825 -2.764  9.356   1.000 29.876  0 63  TYR A CE1 1 ? 
ATOM   505  C CE2 . TYR A 1 63  ? -19.765 -3.194  7.021   1.000 30.436  0 63  TYR A CE2 1 ? 
ATOM   506  C CZ  . TYR A 1 63  ? -20.382 -2.616  8.105   1.000 29.748  0 63  TYR A CZ  1 ? 
ATOM   507  O OH  . TYR A 1 63  ? -21.537 -1.905  7.968   1.000 36.129  0 63  TYR A OH  1 ? 
ATOM   508  N N   . ALA A 1 64  ? -13.301 -3.766  8.578   1.000 22.463  0 64  ALA A N   1 ? 
ATOM   509  C CA  . ALA A 1 64  ? -11.869 -4.012  8.860   1.000 24.922  0 64  ALA A CA  1 ? 
ATOM   510  C C   . ALA A 1 64  ? -11.344 -2.940  9.807   1.000 24.754  0 64  ALA A C   1 ? 
ATOM   511  O O   . ALA A 1 64  ? -10.466 -3.262  10.610  1.000 23.537  0 64  ALA A O   1 ? 
ATOM   512  C CB  . ALA A 1 64  ? -11.050 -4.049  7.597   1.000 25.422  0 64  ALA A CB  1 ? 
ATOM   513  N N   . MET A 1 65  ? -11.785 -1.689  9.648   1.000 21.988  0 65  MET A N   1 ? 
ATOM   514  C CA  . MET A 1 65  ? -11.118 -0.528  10.285  1.000 22.757  0 65  MET A CA  1 ? 
ATOM   515  C C   . MET A 1 65  ? -11.887 -0.141  11.547  1.000 21.869  0 65  MET A C   1 ? 
ATOM   516  O O   . MET A 1 65  ? -11.479 0.830   12.227  1.000 21.575  0 65  MET A O   1 ? 
ATOM   517  C CB  . MET A 1 65  ? -11.044 0.672   9.333   1.000 23.542  0 65  MET A CB  1 ? 
ATOM   518  C CG  . MET A 1 65  ? -10.217 0.427   8.087   1.000 22.866  0 65  MET A CG  1 ? 
ATOM   519  S SD  . MET A 1 65  ? -10.086 1.943   7.061   1.000 25.367  0 65  MET A SD  1 ? 
ATOM   520  C CE  . MET A 1 65  ? -11.672 1.956   6.230   1.000 28.133  0 65  MET A CE  1 ? 
ATOM   521  N N   . ASN A 1 66  ? -12.947 -0.897  11.849  1.000 21.196  0 66  ASN A N   1 ? 
ATOM   522  C CA  . ASN A 1 66  ? -13.787 -0.686  13.041  1.000 20.758  0 66  ASN A CA  1 ? 
ATOM   523  C C   . ASN A 1 66  ? -14.424 0.716   12.955  1.000 20.675  0 66  ASN A C   1 ? 
ATOM   524  O O   . ASN A 1 66  ? -14.441 1.410   13.968  1.000 19.471  0 66  ASN A O   1 ? 
ATOM   525  C CB  . ASN A 1 66  ? -12.963 -0.856  14.311  1.000 20.996  0 66  ASN A CB  1 ? 
ATOM   526  C CG  . ASN A 1 66  ? -13.853 -0.968  15.521  1.000 21.966  0 66  ASN A CG  1 ? 
ATOM   527  O OD1 . ASN A 1 66  ? -15.019 -1.340  15.394  1.000 21.008  0 66  ASN A OD1 1 ? 
ATOM   528  N ND2 . ASN A 1 66  ? -13.317 -0.638  16.682  1.000 20.904  0 66  ASN A ND2 1 ? 
ATOM   529  N N   . THR A 1 67  ? -14.959 1.079   11.782  1.000 21.037  0 67  THR A N   1 ? 
ATOM   530  C CA  . THR A 1 67  ? -15.718 2.330   11.526  1.000 21.152  0 67  THR A CA  1 ? 
ATOM   531  C C   . THR A 1 67  ? -17.111 1.981   10.986  1.000 21.992  0 67  THR A C   1 ? 
ATOM   532  O O   . THR A 1 67  ? -17.701 2.803   10.280  1.000 22.168  0 67  THR A O   1 ? 
ATOM   533  C CB  . THR A 1 67  ? -14.923 3.215   10.573  1.000 19.526  0 67  THR A CB  1 ? 
ATOM   534  O OG1 . THR A 1 67  ? -14.710 2.472   9.369   1.000 22.631  0 67  THR A OG1 1 ? 
ATOM   535  C CG2 . THR A 1 67  ? -13.610 3.638   11.175  1.000 21.747  0 67  THR A CG2 1 ? 
ATOM   536  N N   . GLY A 1 68  ? -17.611 0.803   11.325  1.000 21.793  0 68  GLY A N   1 ? 
ATOM   537  C CA  . GLY A 1 68  ? -18.825 0.241   10.706  1.000 23.081  0 68  GLY A CA  1 ? 
ATOM   538  C C   . GLY A 1 68  ? -20.085 0.829   11.313  1.000 21.091  0 68  GLY A C   1 ? 
ATOM   539  O O   . GLY A 1 68  ? -20.097 1.107   12.538  1.000 20.003  0 68  GLY A O   1 ? 
ATOM   540  N N   . VAL A 1 69  ? -21.101 1.072   10.501  1.000 21.437  0 69  VAL A N   1 ? 
ATOM   541  C CA  . VAL A 1 69  ? -22.421 1.523   11.024  1.000 21.338  0 69  VAL A CA  1 ? 
ATOM   542  C C   . VAL A 1 69  ? -23.518 0.596   10.496  1.000 22.292  0 69  VAL A C   1 ? 
ATOM   543  O O   . VAL A 1 69  ? -23.340 0.015   9.418   1.000 21.109  0 69  VAL A O   1 ? 
ATOM   544  C CB  . VAL A 1 69  ? -22.739 2.976   10.649  1.000 23.125  0 69  VAL A CB  1 ? 
ATOM   545  C CG1 . VAL A 1 69  ? -21.789 3.936   11.350  1.000 24.973  0 69  VAL A CG1 1 ? 
ATOM   546  C CG2 . VAL A 1 69  ? -22.712 3.192   9.146   1.000 25.062  0 69  VAL A CG2 1 ? 
ATOM   547  N N   . LYS A 1 70  ? -24.628 0.528   11.226  1.000 23.641  0 70  LYS A N   1 ? 
ATOM   548  C CA  . LYS A 1 70  ? -25.892 -0.077  10.739  1.000 24.599  0 70  LYS A CA  1 ? 
ATOM   549  C C   . LYS A 1 70  ? -26.485 0.792   9.641   1.000 25.516  0 70  LYS A C   1 ? 
ATOM   550  O O   . LYS A 1 70  ? -26.425 2.025   9.684   1.000 24.555  0 70  LYS A O   1 ? 
ATOM   551  C CB  . LYS A 1 70  ? -26.858 -0.285  11.900  1.000 24.257  0 70  LYS A CB  1 ? 
ATOM   552  C CG  . LYS A 1 70  ? -26.366 -1.321  12.896  1.000 27.634  0 70  LYS A CG  1 ? 
ATOM   553  C CD  . LYS A 1 70  ? -27.209 -1.424  14.123  1.000 29.575  0 70  LYS A CD  1 ? 
ATOM   554  C CE  . LYS A 1 70  ? -26.881 -2.648  14.941  1.000 33.783  0 70  LYS A CE  1 ? 
ATOM   555  N NZ  . LYS A 1 70  ? -27.380 -2.518  16.318  1.000 37.749  0 70  LYS A NZ  1 ? 
ATOM   556  N N   . PRO A 1 71  ? -27.086 0.162   8.608   1.000 26.914  0 71  PRO A N   1 ? 
ATOM   557  C CA  . PRO A 1 71  ? -27.765 0.903   7.573   1.000 27.477  0 71  PRO A CA  1 ? 
ATOM   558  C C   . PRO A 1 71  ? -29.084 1.413   8.163   1.000 29.796  0 71  PRO A C   1 ? 
ATOM   559  O O   . PRO A 1 71  ? -29.548 0.813   9.154   1.000 26.749  0 71  PRO A O   1 ? 
ATOM   560  C CB  . PRO A 1 71  ? -27.933 -0.152  6.477   1.000 29.665  0 71  PRO A CB  1 ? 
ATOM   561  C CG  . PRO A 1 71  ? -28.139 -1.409  7.240   1.000 30.448  0 71  PRO A CG  1 ? 
ATOM   562  C CD  . PRO A 1 71  ? -27.213 -1.285  8.433   1.000 29.118  0 71  PRO A CD  1 ? 
ATOM   563  N N   . LEU A 1 72  ? -29.648 2.468   7.567   1.000 31.017  0 72  LEU A N   1 ? 
ATOM   564  C CA  . LEU A 1 72  ? -31.048 2.891   7.818   1.000 34.606  0 72  LEU A CA  1 ? 
ATOM   565  C C   . LEU A 1 72  ? -31.969 1.730   7.440   1.000 40.659  0 72  LEU A C   1 ? 
ATOM   566  O O   . LEU A 1 72  ? -31.571 0.905   6.569   1.000 36.303  0 72  LEU A O   1 ? 
ATOM   567  C CB  . LEU A 1 72  ? -31.365 4.136   6.983   1.000 34.972  0 72  LEU A CB  1 ? 
ATOM   568  C CG  . LEU A 1 72  ? -30.629 5.408   7.402   1.000 37.391  0 72  LEU A CG  1 ? 
ATOM   569  C CD1 . LEU A 1 72  ? -30.957 6.574   6.477   1.000 37.365  0 72  LEU A CD1 1 ? 
ATOM   570  C CD2 . LEU A 1 72  ? -30.956 5.762   8.847   1.000 40.365  0 72  LEU A CD2 1 ? 
ATOM   571  N N   . GLU A 1 73  ? -33.165 1.681   8.027   1.000 47.717  0 73  GLU A N   1 ? 
ATOM   572  C CA  . GLU A 1 73  ? -34.232 0.737   7.613   1.000 50.462  0 73  GLU A CA  1 ? 
ATOM   573  C C   . GLU A 1 73  ? -34.351 0.815   6.083   1.000 47.594  0 73  GLU A C   1 ? 
ATOM   574  O O   . GLU A 1 73  ? -34.420 1.953   5.533   1.000 46.077  0 73  GLU A O   1 ? 
ATOM   575  C CB  . GLU A 1 73  ? -35.538 1.069   8.338   1.000 60.370  0 73  GLU A CB  1 ? 
ATOM   576  C CG  . GLU A 1 73  ? -36.264 -0.157  8.863   1.000 71.446  0 73  GLU A CG  1 ? 
ATOM   577  C CD  . GLU A 1 73  ? -37.771 0.018   8.915   1.000 83.481  0 73  GLU A CD  1 ? 
ATOM   578  O OE1 . GLU A 1 73  ? -38.475 -0.779  8.269   1.000 89.521  0 73  GLU A OE1 1 ? 
ATOM   579  O OE2 . GLU A 1 73  ? -38.233 0.972   9.573   1.000 90.794  0 73  GLU A OE2 1 ? 
ATOM   580  N N   . GLY A 1 74  ? -34.269 -0.332  5.409   1.000 50.036  0 74  GLY A N   1 ? 
ATOM   581  C CA  . GLY A 1 74  ? -34.358 -0.429  3.942   1.000 50.121  0 74  GLY A CA  1 ? 
ATOM   582  C C   . GLY A 1 74  ? -32.989 -0.446  3.280   1.000 56.867  0 74  GLY A C   1 ? 
ATOM   583  O O   . GLY A 1 74  ? -32.900 -0.958  2.147   1.000 61.368  0 74  GLY A O   1 ? 
ATOM   584  N N   . GLY A 1 75  ? -31.949 0.094   3.932   1.000 48.064  0 75  GLY A N   1 ? 
ATOM   585  C CA  . GLY A 1 75  ? -30.597 0.187   3.344   1.000 43.659  0 75  GLY A CA  1 ? 
ATOM   586  C C   . GLY A 1 75  ? -29.856 -1.135  3.429   1.000 41.784  0 75  GLY A C   1 ? 
ATOM   587  O O   . GLY A 1 75  ? -30.379 -2.079  4.038   1.000 42.318  0 75  GLY A O   1 ? 
ATOM   588  N N   . GLU A 1 76  ? -28.667 -1.203  2.827   1.000 43.787  0 76  GLU A N   1 ? 
ATOM   589  C CA  . GLU A 1 76  ? -27.777 -2.398  2.827   1.000 42.405  0 76  GLU A CA  1 ? 
ATOM   590  C C   . GLU A 1 76  ? -26.447 -2.029  3.483   1.000 40.095  0 76  GLU A C   1 ? 
ATOM   591  O O   . GLU A 1 76  ? -25.950 -0.925  3.215   1.000 35.892  0 76  GLU A O   1 ? 
ATOM   592  C CB  . GLU A 1 76  ? -27.470 -2.854  1.399   1.000 44.727  0 76  GLU A CB  1 ? 
ATOM   593  C CG  . GLU A 1 76  ? -28.674 -3.383  0.661   1.000 50.040  0 76  GLU A CG  1 ? 
ATOM   594  C CD  . GLU A 1 76  ? -28.407 -3.807  -0.770  1.000 55.844  0 76  GLU A CD  1 ? 
ATOM   595  O OE1 . GLU A 1 76  ? -29.398 -4.093  -1.464  1.000 65.779  0 76  GLU A OE1 1 ? 
ATOM   596  O OE2 . GLU A 1 76  ? -27.213 -3.859  -1.192  1.000 52.423  0 76  GLU A OE2 1 ? 
ATOM   597  N N   . TYR A 1 77  ? -25.841 -2.938  4.220   1.000 34.946  0 77  TYR A N   1 ? 
ATOM   598  C CA  . TYR A 1 77  ? -24.422 -2.787  4.606   1.000 37.221  0 77  TYR A CA  1 ? 
ATOM   599  C C   . TYR A 1 77  ? -23.554 -3.458  3.551   1.000 36.864  0 77  TYR A C   1 ? 
ATOM   600  O O   . TYR A 1 77  ? -24.029 -4.308  2.764   1.000 36.576  0 77  TYR A O   1 ? 
ATOM   601  C CB  . TYR A 1 77  ? -24.135 -3.279  6.028   1.000 39.038  0 77  TYR A CB  1 ? 
ATOM   602  C CG  . TYR A 1 77  ? -24.551 -4.692  6.337   1.000 39.921  0 77  TYR A CG  1 ? 
ATOM   603  C CD1 . TYR A 1 77  ? -25.713 -4.961  7.050   1.000 44.293  0 77  TYR A CD1 1 ? 
ATOM   604  C CD2 . TYR A 1 77  ? -23.720 -5.746  6.022   1.000 37.141  0 77  TYR A CD2 1 ? 
ATOM   605  C CE1 . TYR A 1 77  ? -26.086 -6.258  7.368   1.000 41.555  0 77  TYR A CE1 1 ? 
ATOM   606  C CE2 . TYR A 1 77  ? -24.061 -7.041  6.352   1.000 43.721  0 77  TYR A CE2 1 ? 
ATOM   607  C CZ  . TYR A 1 77  ? -25.242 -7.303  7.033   1.000 44.630  0 77  TYR A CZ  1 ? 
ATOM   608  O OH  . TYR A 1 77  ? -25.553 -8.604  7.320   1.000 47.776  0 77  TYR A OH  1 ? 
ATOM   609  N N   . ASP A 1 78  ? -22.316 -3.000  3.534   1.000 35.146  0 78  ASP A N   1 ? 
ATOM   610  C CA  . ASP A 1 78  ? -21.279 -3.288  2.536   1.000 35.424  0 78  ASP A CA  1 ? 
ATOM   611  C C   . ASP A 1 78  ? -20.233 -4.172  3.207   1.000 30.298  0 78  ASP A C   1 ? 
ATOM   612  O O   . ASP A 1 78  ? -19.465 -3.671  4.013   1.000 29.241  0 78  ASP A O   1 ? 
ATOM   613  C CB  . ASP A 1 78  ? -20.691 -1.962  2.042   1.000 44.280  0 78  ASP A CB  1 ? 
ATOM   614  C CG  . ASP A 1 78  ? -19.650 -2.097  0.945   1.000 59.603  0 78  ASP A CG  1 ? 
ATOM   615  O OD1 . ASP A 1 78  ? -19.707 -3.115  0.197   1.000 65.045  0 78  ASP A OD1 1 ? 
ATOM   616  O OD2 . ASP A 1 78  ? -18.782 -1.184  0.841   1.000 65.093  0 78  ASP A OD2 1 ? 
ATOM   617  N N   . ILE A 1 79  ? -20.188 -5.429  2.850   1.000 25.661  0 79  ILE A N   1 ? 
ATOM   618  C CA  . ILE A 1 79  ? -19.054 -6.310  3.216   1.000 29.096  0 79  ILE A CA  1 ? 
ATOM   619  C C   . ILE A 1 79  ? -18.002 -6.168  2.131   1.000 26.102  0 79  ILE A C   1 ? 
ATOM   620  O O   . ILE A 1 79  ? -18.262 -6.545  0.973   1.000 28.982  0 79  ILE A O   1 ? 
ATOM   621  C CB  . ILE A 1 79  ? -19.515 -7.765  3.365   1.000 31.895  0 79  ILE A CB  1 ? 
ATOM   622  C CG1 . ILE A 1 79  ? -20.411 -7.946  4.587   1.000 34.707  0 79  ILE A CG1 1 ? 
ATOM   623  C CG2 . ILE A 1 79  ? -18.329 -8.712  3.389   1.000 33.867  0 79  ILE A CG2 1 ? 
ATOM   624  C CD1 . ILE A 1 79  ? -20.814 -9.377  4.816   1.000 37.137  0 79  ILE A CD1 1 ? 
ATOM   625  N N   . ASP A 1 80  ? -16.853 -5.670  2.507   1.000 24.907  0 80  ASP A N   1 ? 
ATOM   626  C CA  . ASP A 1 80  ? -15.739 -5.410  1.589   1.000 28.297  0 80  ASP A CA  1 ? 
ATOM   627  C C   . ASP A 1 80  ? -14.675 -6.439  1.880   1.000 26.118  0 80  ASP A C   1 ? 
ATOM   628  O O   . ASP A 1 80  ? -14.218 -6.501  3.029   1.000 25.987  0 80  ASP A O   1 ? 
ATOM   629  C CB  . ASP A 1 80  ? -15.122 -4.038  1.824   1.000 33.939  0 80  ASP A CB  1 ? 
ATOM   630  C CG  . ASP A 1 80  ? -15.829 -2.916  1.132   1.000 39.658  0 80  ASP A CG  1 ? 
ATOM   631  O OD1 . ASP A 1 80  ? -15.275 -1.818  1.140   1.000 50.069  0 80  ASP A OD1 1 ? 
ATOM   632  O OD2 . ASP A 1 80  ? -16.920 -3.156  0.601   1.000 50.863  0 80  ASP A OD2 1 ? 
ATOM   633  N N   . VAL A 1 81  ? -14.244 -7.157  0.868   1.000 26.149  0 81  VAL A N   1 ? 
ATOM   634  C CA  . VAL A 1 81  ? -13.110 -8.093  1.017   1.000 25.380  0 81  VAL A CA  1 ? 
ATOM   635  C C   . VAL A 1 81  ? -12.225 -7.971  -0.220  1.000 24.019  0 81  VAL A C   1 ? 
ATOM   636  O O   . VAL A 1 81  ? -12.759 -7.703  -1.333  1.000 25.204  0 81  VAL A O   1 ? 
ATOM   637  C CB  . VAL A 1 81  ? -13.654 -9.514  1.262   1.000 28.883  0 81  VAL A CB  1 ? 
ATOM   638  C CG1 . VAL A 1 81  ? -14.471 -9.995  0.103   1.000 33.605  0 81  VAL A CG1 1 ? 
ATOM   639  C CG2 . VAL A 1 81  ? -12.569 -10.504 1.586   1.000 32.307  0 81  VAL A CG2 1 ? 
ATOM   640  N N   . GLY A 1 82  ? -10.934 -8.161  -0.020  1.000 20.292  0 82  GLY A N   1 ? 
ATOM   641  C CA  . GLY A 1 82  ? -9.926  -8.224  -1.075  1.000 23.630  0 82  GLY A CA  1 ? 
ATOM   642  C C   . GLY A 1 82  ? -9.610  -9.656  -1.382  1.000 24.939  0 82  GLY A C   1 ? 
ATOM   643  O O   . GLY A 1 82  ? -9.430  -10.431 -0.417  1.000 24.550  0 82  GLY A O   1 ? 
ATOM   644  N N   . ILE A 1 83  ? -9.545  -10.017 -2.663  1.000 23.953  0 83  ILE A N   1 ? 
ATOM   645  C CA  . ILE A 1 83  ? -9.044  -11.356 -3.051  1.000 23.811  0 83  ILE A CA  1 ? 
ATOM   646  C C   . ILE A 1 83  ? -7.827  -11.169 -3.944  1.000 23.371  0 83  ILE A C   1 ? 
ATOM   647  O O   . ILE A 1 83  ? -7.889  -10.425 -4.945  1.000 22.263  0 83  ILE A O   1 ? 
ATOM   648  C CB  . ILE A 1 83  ? -10.174 -12.246 -3.622  1.000 24.561  0 83  ILE A CB  1 ? 
ATOM   649  C CG1 . ILE A 1 83  ? -10.826 -11.682 -4.875  1.000 25.577  0 83  ILE A CG1 1 ? 
ATOM   650  C CG2 . ILE A 1 83  ? -11.233 -12.482 -2.549  1.000 27.458  0 83  ILE A CG2 1 ? 
ATOM   651  C CD1 . ILE A 1 83  ? -11.900 -12.558 -5.474  1.000 28.522  0 83  ILE A CD1 1 ? 
ATOM   652  N N   . ILE A 1 84  ? -6.718  -11.741 -3.517  1.000 21.035  0 84  ILE A N   1 ? 
ATOM   653  C CA  . ILE A 1 84  ? -5.434  -11.674 -4.243  1.000 23.282  0 84  ILE A CA  1 ? 
ATOM   654  C C   . ILE A 1 84  ? -5.280  -12.962 -5.068  1.000 25.549  0 84  ILE A C   1 ? 
ATOM   655  O O   . ILE A 1 84  ? -5.023  -14.018 -4.487  1.000 27.712  0 84  ILE A O   1 ? 
ATOM   656  C CB  . ILE A 1 84  ? -4.280  -11.479 -3.274  1.000 21.530  0 84  ILE A CB  1 ? 
ATOM   657  C CG1 . ILE A 1 84  ? -4.519  -10.288 -2.343  1.000 23.464  0 84  ILE A CG1 1 ? 
ATOM   658  C CG2 . ILE A 1 84  ? -3.001  -11.359 -4.074  1.000 23.138  0 84  ILE A CG2 1 ? 
ATOM   659  C CD1 . ILE A 1 84  ? -3.332  -9.940  -1.457  1.000 23.649  0 84  ILE A CD1 1 ? 
ATOM   660  N N   . LEU A 1 85  ? -5.574  -12.912 -6.356  1.000 26.450  0 85  LEU A N   1 ? 
ATOM   661  C CA  . LEU A 1 85  ? -5.490  -14.114 -7.218  1.000 28.884  0 85  LEU A CA  1 ? 
ATOM   662  C C   . LEU A 1 85  ? -4.017  -14.433 -7.467  1.000 29.057  0 85  LEU A C   1 ? 
ATOM   663  O O   . LEU A 1 85  ? -3.199  -13.514 -7.512  1.000 27.211  0 85  LEU A O   1 ? 
ATOM   664  C CB  . LEU A 1 85  ? -6.302  -13.891 -8.492  1.000 30.976  0 85  LEU A CB  1 ? 
ATOM   665  C CG  . LEU A 1 85  ? -7.778  -14.235 -8.327  1.000 39.661  0 85  LEU A CG  1 ? 
ATOM   666  C CD1 . LEU A 1 85  ? -8.591  -13.015 -7.963  1.000 42.370  0 85  LEU A CD1 1 ? 
ATOM   667  C CD2 . LEU A 1 85  ? -8.349  -14.888 -9.567  1.000 49.268  0 85  LEU A CD2 1 ? 
ATOM   668  N N   . ASN A 1 86  ? -3.679  -15.713 -7.581  1.000 34.512  0 86  ASN A N   1 ? 
ATOM   669  C CA  . ASN A 1 86  ? -2.279  -16.178 -7.784  1.000 38.117  0 86  ASN A CA  1 ? 
ATOM   670  C C   . ASN A 1 86  ? -1.957  -16.100 -9.272  1.000 35.514  0 86  ASN A C   1 ? 
ATOM   671  O O   . ASN A 1 86  ? -1.768  -17.149 -9.891  1.000 32.801  0 86  ASN A O   1 ? 
ATOM   672  C CB  . ASN A 1 86  ? -2.064  -17.563 -7.157  1.000 44.229  0 86  ASN A CB  1 ? 
ATOM   673  C CG  . ASN A 1 86  ? -2.349  -17.518 -5.668  1.000 52.802  0 86  ASN A CG  1 ? 
ATOM   674  O OD1 . ASN A 1 86  ? -3.218  -18.242 -5.151  1.000 59.148  0 86  ASN A OD1 1 ? 
ATOM   675  N ND2 . ASN A 1 86  ? -1.700  -16.574 -4.991  1.000 57.183  0 86  ASN A ND2 1 ? 
ATOM   676  N N   . ILE A 1 87  ? -1.959  -14.885 -9.814  1.000 30.276  0 87  ILE A N   1 ? 
ATOM   677  C CA  . ILE A 1 87  ? -1.703  -14.583 -11.250 1.000 30.032  0 87  ILE A CA  1 ? 
ATOM   678  C C   . ILE A 1 87  ? -0.676  -13.475 -11.310 1.000 30.128  0 87  ILE A C   1 ? 
ATOM   679  O O   . ILE A 1 87  ? -0.538  -12.733 -10.303 1.000 28.428  0 87  ILE A O   1 ? 
ATOM   680  C CB  . ILE A 1 87  ? -2.980  -14.171 -12.001 1.000 31.861  0 87  ILE A CB  1 ? 
ATOM   681  C CG1 . ILE A 1 87  ? -3.565  -12.876 -11.418 1.000 30.014  0 87  ILE A CG1 1 ? 
ATOM   682  C CG2 . ILE A 1 87  ? -3.982  -15.318 -12.034 1.000 33.597  0 87  ILE A CG2 1 ? 
ATOM   683  C CD1 . ILE A 1 87  ? -4.830  -12.433 -12.050 1.000 33.932  0 87  ILE A CD1 1 ? 
ATOM   684  N N   . ALA A 1 88  ? -0.031  -13.340 -12.477 1.000 29.228  0 88  ALA A N   1 ? 
ATOM   685  C CA  . ALA A 1 88  ? 0.813   -12.192 -12.864 1.000 27.186  0 88  ALA A CA  1 ? 
ATOM   686  C C   . ALA A 1 88  ? -0.073  -11.200 -13.618 1.000 27.239  0 88  ALA A C   1 ? 
ATOM   687  O O   . ALA A 1 88  ? -0.765  -11.627 -14.587 1.000 25.849  0 88  ALA A O   1 ? 
ATOM   688  C CB  . ALA A 1 88  ? 1.959   -12.670 -13.715 1.000 32.358  0 88  ALA A CB  1 ? 
ATOM   689  N N   . LYS A 1 89  ? -0.122  -9.946  -13.167 1.000 30.651  0 89  LYS A N   1 ? 
ATOM   690  C CA  . LYS A 1 89  ? -1.069  -8.934  -13.733 1.000 32.773  0 89  LYS A CA  1 ? 
ATOM   691  C C   . LYS A 1 89  ? -0.838  -8.830  -15.252 1.000 31.625  0 89  LYS A C   1 ? 
ATOM   692  O O   . LYS A 1 89  ? -1.831  -8.754  -16.024 1.000 31.116  0 89  LYS A O   1 ? 
ATOM   693  C CB  . LYS A 1 89  ? -0.918  -7.579  -13.032 1.000 29.508  0 89  LYS A CB  1 ? 
ATOM   694  C CG  . LYS A 1 89  ? 0.411   -6.872  -13.209 1.000 29.702  0 89  LYS A CG  1 ? 
ATOM   695  C CD  . LYS A 1 89  ? 0.474   -5.616  -12.359 1.000 33.641  0 89  LYS A CD  1 ? 
ATOM   696  C CE  . LYS A 1 89  ? 1.755   -4.821  -12.511 1.000 32.056  0 89  LYS A CE  1 ? 
ATOM   697  N NZ  . LYS A 1 89  ? 1.961   -4.388  -13.913 1.000 34.248  0 89  LYS A NZ  1 ? 
ATOM   698  N N   . ASP A 1 90  ? 0.416   -8.866  -15.669 1.000 32.866  0 90  ASP A N   1 ? 
ATOM   699  C CA  . ASP A 1 90  ? 0.799   -8.650  -17.089 1.000 39.180  0 90  ASP A CA  1 ? 
ATOM   700  C C   . ASP A 1 90  ? 0.311   -9.796  -17.979 1.000 36.832  0 90  ASP A C   1 ? 
ATOM   701  O O   . ASP A 1 90  ? 0.359   -9.588  -19.191 1.000 37.232  0 90  ASP A O   1 ? 
ATOM   702  C CB  . ASP A 1 90  ? 2.309   -8.489  -17.245 1.000 38.623  0 90  ASP A CB  1 ? 
ATOM   703  C CG  . ASP A 1 90  ? 2.849   -7.175  -16.716 1.000 40.593  0 90  ASP A CG  1 ? 
ATOM   704  O OD1 . ASP A 1 90  ? 2.032   -6.303  -16.346 1.000 40.861  0 90  ASP A OD1 1 ? 
ATOM   705  O OD2 . ASP A 1 90  ? 4.081   -7.026  -16.692 1.000 46.679  0 90  ASP A OD2 1 ? 
ATOM   706  N N   . ASP A 1 91  ? -0.135  -10.941 -17.421 1.000 31.108  0 91  ASP A N   1 ? 
ATOM   707  C CA  . ASP A 1 91  ? -0.628  -12.116 -18.206 1.000 30.692  0 91  ASP A CA  1 ? 
ATOM   708  C C   . ASP A 1 91  ? -2.127  -12.009 -18.459 1.000 31.772  0 91  ASP A C   1 ? 
ATOM   709  O O   . ASP A 1 91  ? -2.629  -12.798 -19.233 1.000 33.720  0 91  ASP A O   1 ? 
ATOM   710  C CB  . ASP A 1 91  ? -0.394  -13.464 -17.516 1.000 33.751  0 91  ASP A CB  1 ? 
ATOM   711  C CG  . ASP A 1 91  ? 1.052   -13.937 -17.507 1.000 34.191  0 91  ASP A CG  1 ? 
ATOM   712  O OD1 . ASP A 1 91  ? 1.339   -14.921 -16.792 1.000 43.754  0 91  ASP A OD1 1 ? 
ATOM   713  O OD2 . ASP A 1 91  ? 1.879   -13.306 -18.181 1.000 38.399  0 91  ASP A OD2 1 ? 
ATOM   714  N N   . HIS A 1 92  ? -2.849  -11.132 -17.768 1.000 31.231  0 92  HIS A N   1 ? 
ATOM   715  C CA  . HIS A 1 92  ? -4.328  -11.112 -17.860 1.000 32.581  0 92  HIS A CA  1 ? 
ATOM   716  C C   . HIS A 1 92  ? -4.847  -9.703  -18.007 1.000 32.349  0 92  HIS A C   1 ? 
ATOM   717  O O   . HIS A 1 92  ? -4.293  -8.796  -17.405 1.000 37.335  0 92  HIS A O   1 ? 
ATOM   718  C CB  . HIS A 1 92  ? -4.971  -11.807 -16.667 1.000 33.458  0 92  HIS A CB  1 ? 
ATOM   719  C CG  . HIS A 1 92  ? -4.468  -13.188 -16.485 1.000 32.637  0 92  HIS A CG  1 ? 
ATOM   720  N ND1 . HIS A 1 92  ? -5.080  -14.288 -17.092 1.000 33.678  0 92  HIS A ND1 1 ? 
ATOM   721  C CD2 . HIS A 1 92  ? -3.389  -13.650 -15.814 1.000 31.643  0 92  HIS A CD2 1 ? 
ATOM   722  C CE1 . HIS A 1 92  ? -4.418  -15.379 -16.741 1.000 34.367  0 92  HIS A CE1 1 ? 
ATOM   723  N NE2 . HIS A 1 92  ? -3.372  -15.008 -15.954 1.000 31.571  0 92  HIS A NE2 1 ? 
ATOM   724  N N   . ASP A 1 93  ? -5.895  -9.571  -18.798 1.000 29.203  0 93  ASP A N   1 ? 
ATOM   725  C CA  . ASP A 1 93  ? -6.749  -8.383  -18.820 1.000 27.982  0 93  ASP A CA  1 ? 
ATOM   726  C C   . ASP A 1 93  ? -7.505  -8.309  -17.486 1.000 27.342  0 93  ASP A C   1 ? 
ATOM   727  O O   . ASP A 1 93  ? -8.179  -9.258  -17.078 1.000 24.393  0 93  ASP A O   1 ? 
ATOM   728  C CB  . ASP A 1 93  ? -7.661  -8.478  -20.023 1.000 28.402  0 93  ASP A CB  1 ? 
ATOM   729  C CG  . ASP A 1 93  ? -8.531  -7.282  -20.184 1.000 30.102  0 93  ASP A CG  1 ? 
ATOM   730  O OD1 . ASP A 1 93  ? -8.451  -6.658  -21.257 1.000 33.416  0 93  ASP A OD1 1 ? 
ATOM   731  O OD2 . ASP A 1 93  ? -9.310  -7.016  -19.265 1.000 35.751  0 93  ASP A OD2 1 ? 
ATOM   732  N N   . PRO A 1 94  ? -7.460  -7.155  -16.793 1.000 26.668  0 94  PRO A N   1 ? 
ATOM   733  C CA  . PRO A 1 94  ? -8.084  -7.029  -15.471 1.000 24.608  0 94  PRO A CA  1 ? 
ATOM   734  C C   . PRO A 1 94  ? -9.588  -7.326  -15.520 1.000 25.150  0 94  PRO A C   1 ? 
ATOM   735  O O   . PRO A 1 94  ? -10.142 -7.888  -14.541 1.000 24.154  0 94  PRO A O   1 ? 
ATOM   736  C CB  . PRO A 1 94  ? -7.803  -5.554  -15.074 1.000 24.931  0 94  PRO A CB  1 ? 
ATOM   737  C CG  . PRO A 1 94  ? -7.414  -4.852  -16.373 1.000 25.573  0 94  PRO A CG  1 ? 
ATOM   738  C CD  . PRO A 1 94  ? -6.774  -5.922  -17.226 1.000 24.191  0 94  PRO A CD  1 ? 
ATOM   739  N N   . VAL A 1 95  ? -10.245 -6.930  -16.616 1.000 21.637  0 95  VAL A N   1 ? 
ATOM   740  C CA  . VAL A 1 95  ? -11.696 -7.176  -16.808 1.000 23.421  0 95  VAL A CA  1 ? 
ATOM   741  C C   . VAL A 1 95  ? -11.935 -8.686  -16.893 1.000 23.002  0 95  VAL A C   1 ? 
ATOM   742  O O   . VAL A 1 95  ? -12.940 -9.154  -16.321 1.000 26.173  0 95  VAL A O   1 ? 
ATOM   743  C CB  . VAL A 1 95  ? -12.275 -6.425  -18.022 1.000 27.100  0 95  VAL A CB  1 ? 
ATOM   744  C CG1 . VAL A 1 95  ? -13.726 -6.823  -18.286 1.000 29.260  0 95  VAL A CG1 1 ? 
ATOM   745  C CG2 . VAL A 1 95  ? -12.169 -4.916  -17.852 1.000 26.805  0 95  VAL A CG2 1 ? 
ATOM   746  N N   . GLU A 1 96  ? -11.044 -9.426  -17.524 1.000 25.097  0 96  GLU A N   1 ? 
ATOM   747  C CA  . GLU A 1 96  ? -11.238 -10.888 -17.770 1.000 29.035  0 96  GLU A CA  1 ? 
ATOM   748  C C   . GLU A 1 96  ? -11.103 -11.630 -16.435 1.000 30.756  0 96  GLU A C   1 ? 
ATOM   749  O O   . GLU A 1 96  ? -11.861 -12.584 -16.221 1.000 28.136  0 96  GLU A O   1 ? 
ATOM   750  C CB  . GLU A 1 96  ? -10.246 -11.442 -18.795 1.000 29.482  0 96  GLU A CB  1 ? 
ATOM   751  C CG  . GLU A 1 96  ? -10.553 -10.995 -20.226 1.000 33.080  0 96  GLU A CG  1 ? 
ATOM   752  C CD  . GLU A 1 96  ? -11.894 -11.477 -20.735 1.000 30.433  0 96  GLU A CD  1 ? 
ATOM   753  O OE1 . GLU A 1 96  ? -12.261 -12.613 -20.424 1.000 44.127  0 96  GLU A OE1 1 ? 
ATOM   754  O OE2 . GLU A 1 96  ? -12.599 -10.699 -21.363 1.000 28.795  0 96  GLU A OE2 1 ? 
ATOM   755  N N   . VAL A 1 97  ? -10.218 -11.158 -15.556 1.000 30.682  0 97  VAL A N   1 ? 
ATOM   756  C CA  . VAL A 1 97  ? -10.070 -11.727 -14.185 1.000 27.862  0 97  VAL A CA  1 ? 
ATOM   757  C C   . VAL A 1 97  ? -11.365 -11.467 -13.414 1.000 26.255  0 97  VAL A C   1 ? 
ATOM   758  O O   . VAL A 1 97  ? -11.840 -12.371 -12.761 1.000 30.092  0 97  VAL A O   1 ? 
ATOM   759  C CB  . VAL A 1 97  ? -8.801  -11.184 -13.505 1.000 27.640  0 97  VAL A CB  1 ? 
ATOM   760  C CG1 . VAL A 1 97  ? -8.670  -11.647 -12.076 1.000 30.695  0 97  VAL A CG1 1 ? 
ATOM   761  C CG2 . VAL A 1 97  ? -7.570  -11.586 -14.287 1.000 27.408  0 97  VAL A CG2 1 ? 
ATOM   762  N N   . LYS A 1 98  ? -11.973 -10.294 -13.539 1.000 23.814  0 98  LYS A N   1 ? 
ATOM   763  C CA  . LYS A 1 98  ? -13.199 -10.024 -12.793 1.000 24.936  0 98  LYS A CA  1 ? 
ATOM   764  C C   . LYS A 1 98  ? -14.302 -10.938 -13.349 1.000 29.480  0 98  LYS A C   1 ? 
ATOM   765  O O   . LYS A 1 98  ? -15.136 -11.406 -12.552 1.000 27.881  0 98  LYS A O   1 ? 
ATOM   766  C CB  . LYS A 1 98  ? -13.507 -8.532  -12.802 1.000 24.390  0 98  LYS A CB  1 ? 
ATOM   767  C CG  . LYS A 1 98  ? -12.585 -7.728  -11.885 1.000 24.700  0 98  LYS A CG  1 ? 
ATOM   768  C CD  . LYS A 1 98  ? -13.093 -6.356  -11.569 1.000 24.893  0 98  LYS A CD  1 ? 
ATOM   769  C CE  . LYS A 1 98  ? -12.954 -5.459  -12.776 1.000 27.839  0 98  LYS A CE  1 ? 
ATOM   770  N NZ  . LYS A 1 98  ? -13.211 -4.045  -12.451 1.000 28.039  0 98  LYS A NZ  1 ? 
ATOM   771  N N   . LYS A 1 99  ? -14.259 -11.260 -14.639 1.000 26.849  0 99  LYS A N   1 ? 
ATOM   772  C CA  . LYS A 1 99  ? -15.264 -12.168 -15.271 1.000 32.408  0 99  LYS A CA  1 ? 
ATOM   773  C C   . LYS A 1 99  ? -15.182 -13.569 -14.652 1.000 26.433  0 99  LYS A C   1 ? 
ATOM   774  O O   . LYS A 1 99  ? -16.237 -14.178 -14.526 1.000 32.704  0 99  LYS A O   1 ? 
ATOM   775  C CB  . LYS A 1 99  ? -15.094 -12.231 -16.797 1.000 31.230  0 99  LYS A CB  1 ? 
ATOM   776  C CG  . LYS A 1 99  ? -15.510 -10.962 -17.524 1.000 34.838  0 99  LYS A CG  1 ? 
ATOM   777  C CD  . LYS A 1 99  ? -14.976 -10.876 -18.954 1.000 38.625  0 99  LYS A CD  1 ? 
ATOM   778  C CE  . LYS A 1 99  ? -15.769 -11.722 -19.934 1.000 39.763  0 99  LYS A CE  1 ? 
ATOM   779  N NZ  . LYS A 1 99  ? -15.008 -11.996 -21.180 1.000 44.970  0 99  LYS A NZ  1 ? 
ATOM   780  N N   . TRP A 1 100 ? -13.989 -14.068 -14.312 1.000 25.022  0 100 TRP A N   1 ? 
ATOM   781  C CA  . TRP A 1 100 ? -13.828 -15.342 -13.555 1.000 26.131  0 100 TRP A CA  1 ? 
ATOM   782  C C   . TRP A 1 100 ? -14.768 -15.323 -12.333 1.000 27.493  0 100 TRP A C   1 ? 
ATOM   783  O O   . TRP A 1 100 ? -15.528 -16.294 -12.105 1.000 28.043  0 100 TRP A O   1 ? 
ATOM   784  C CB  . TRP A 1 100 ? -12.376 -15.544 -13.097 1.000 24.608  0 100 TRP A CB  1 ? 
ATOM   785  C CG  . TRP A 1 100 ? -11.364 -15.562 -14.200 1.000 24.065  0 100 TRP A CG  1 ? 
ATOM   786  C CD1 . TRP A 1 100 ? -11.629 -15.600 -15.542 1.000 25.266  0 100 TRP A CD1 1 ? 
ATOM   787  C CD2 . TRP A 1 100 ? -9.927  -15.604 -14.073 1.000 22.997  0 100 TRP A CD2 1 ? 
ATOM   788  N NE1 . TRP A 1 100 ? -10.460 -15.650 -16.252 1.000 24.175  0 100 TRP A NE1 1 ? 
ATOM   789  C CE2 . TRP A 1 100 ? -9.398  -15.616 -15.383 1.000 24.786  0 100 TRP A CE2 1 ? 
ATOM   790  C CE3 . TRP A 1 100 ? -9.034  -15.543 -12.999 1.000 22.807  0 100 TRP A CE3 1 ? 
ATOM   791  C CZ2 . TRP A 1 100 ? -8.024  -15.585 -15.638 1.000 25.369  0 100 TRP A CZ2 1 ? 
ATOM   792  C CZ3 . TRP A 1 100 ? -7.681  -15.563 -13.246 1.000 23.540  0 100 TRP A CZ3 1 ? 
ATOM   793  C CH2 . TRP A 1 100 ? -7.179  -15.561 -14.556 1.000 24.307  0 100 TRP A CH2 1 ? 
ATOM   794  N N   . ILE A 1 101 ? -14.724 -14.225 -11.580 1.000 27.778  0 101 ILE A N   1 ? 
ATOM   795  C CA  . ILE A 1 101 ? -15.335 -14.097 -10.241 1.000 24.753  0 101 ILE A CA  1 ? 
ATOM   796  C C   . ILE A 1 101 ? -16.818 -13.881 -10.462 1.000 29.784  0 101 ILE A C   1 ? 
ATOM   797  O O   . ILE A 1 101 ? -17.610 -14.377 -9.645  1.000 28.448  0 101 ILE A O   1 ? 
ATOM   798  C CB  . ILE A 1 101 ? -14.683 -12.937 -9.450  1.000 23.355  0 101 ILE A CB  1 ? 
ATOM   799  C CG1 . ILE A 1 101 ? -13.161 -13.061 -9.321  1.000 22.416  0 101 ILE A CG1 1 ? 
ATOM   800  C CG2 . ILE A 1 101 ? -15.357 -12.784 -8.108  1.000 24.492  0 101 ILE A CG2 1 ? 
ATOM   801  C CD1 . ILE A 1 101 ? -12.653 -14.350 -8.757  1.000 24.168  0 101 ILE A CD1 1 ? 
ATOM   802  N N   . ARG A 1 102 ? -17.184 -13.167 -11.539 1.000 28.270  0 102 ARG A N   1 ? 
ATOM   803  C CA  . ARG A 1 102 ? -18.601 -13.002 -11.937 1.000 30.012  0 102 ARG A CA  1 ? 
ATOM   804  C C   . ARG A 1 102 ? -19.167 -14.385 -12.280 1.000 32.193  0 102 ARG A C   1 ? 
ATOM   805  O O   . ARG A 1 102 ? -20.280 -14.717 -11.818 1.000 36.005  0 102 ARG A O   1 ? 
ATOM   806  C CB  . ARG A 1 102 ? -18.734 -12.017 -13.107 1.000 31.452  0 102 ARG A CB  1 ? 
ATOM   807  C CG  . ARG A 1 102 ? -20.181 -11.694 -13.494 1.000 35.563  0 102 ARG A CG  1 ? 
ATOM   808  C CD  . ARG A 1 102 ? -20.781 -12.653 -14.517 1.000 34.297  0 102 ARG A CD  1 ? 
ATOM   809  N NE  . ARG A 1 102 ? -19.822 -13.033 -15.579 1.000 38.014  0 102 ARG A NE  1 ? 
ATOM   810  C CZ  . ARG A 1 102 ? -19.473 -12.261 -16.634 1.000 35.458  0 102 ARG A CZ  1 ? 
ATOM   811  N NH1 . ARG A 1 102 ? -18.590 -12.703 -17.517 1.000 39.793  0 102 ARG A NH1 1 ? 
ATOM   812  N NH2 . ARG A 1 102 ? -19.988 -11.057 -16.786 1.000 31.022  0 102 ARG A NH2 1 ? 
ATOM   813  N N   . ASP A 1 103 ? -18.430 -15.165 -13.055 1.000 33.281  0 103 ASP A N   1 ? 
ATOM   814  C CA  . ASP A 1 103 ? -18.922 -16.469 -13.562 1.000 36.130  0 103 ASP A CA  1 ? 
ATOM   815  C C   . ASP A 1 103 ? -19.005 -17.466 -12.382 1.000 40.408  0 103 ASP A C   1 ? 
ATOM   816  O O   . ASP A 1 103 ? -20.025 -18.184 -12.272 1.000 38.751  0 103 ASP A O   1 ? 
ATOM   817  C CB  . ASP A 1 103 ? -18.011 -17.009 -14.665 1.000 38.302  0 103 ASP A CB  1 ? 
ATOM   818  C CG  . ASP A 1 103 ? -17.996 -16.226 -15.973 1.000 32.325  0 103 ASP A CG  1 ? 
ATOM   819  O OD1 . ASP A 1 103 ? -17.135 -16.538 -16.784 1.000 37.544  0 103 ASP A OD1 1 ? 
ATOM   820  O OD2 . ASP A 1 103 ? -18.815 -15.281 -16.136 1.000 32.809  0 103 ASP A OD2 1 ? 
ATOM   821  N N   . ALA A 1 104 ? -17.982 -17.490 -11.516 1.000 39.568  0 104 ALA A N   1 ? 
ATOM   822  C CA  . ALA A 1 104 ? -17.941 -18.292 -10.265 1.000 34.871  0 104 ALA A CA  1 ? 
ATOM   823  C C   . ALA A 1 104 ? -19.211 -18.062 -9.410  1.000 36.459  0 104 ALA A C   1 ? 
ATOM   824  O O   . ALA A 1 104 ? -19.638 -18.996 -8.750  1.000 44.634  0 104 ALA A O   1 ? 
ATOM   825  C CB  . ALA A 1 104 ? -16.685 -17.977 -9.501  1.000 33.755  0 104 ALA A CB  1 ? 
ATOM   826  N N   . LEU A 1 105 ? -19.800 -16.871 -9.438  1.000 35.398  0 105 LEU A N   1 ? 
ATOM   827  C CA  . LEU A 1 105 ? -20.906 -16.463 -8.543  1.000 35.485  0 105 LEU A CA  1 ? 
ATOM   828  C C   . LEU A 1 105 ? -22.215 -16.353 -9.325  1.000 40.814  0 105 LEU A C   1 ? 
ATOM   829  O O   . LEU A 1 105 ? -23.126 -15.655 -8.838  1.000 39.287  0 105 LEU A O   1 ? 
ATOM   830  C CB  . LEU A 1 105 ? -20.555 -15.110 -7.916  1.000 38.022  0 105 LEU A CB  1 ? 
ATOM   831  C CG  . LEU A 1 105 ? -19.382 -15.099 -6.935  1.000 36.693  0 105 LEU A CG  1 ? 
ATOM   832  C CD1 . LEU A 1 105 ? -19.188 -13.702 -6.379  1.000 37.051  0 105 LEU A CD1 1 ? 
ATOM   833  C CD2 . LEU A 1 105 ? -19.616 -16.082 -5.784  1.000 36.589  0 105 LEU A CD2 1 ? 
ATOM   834  N N   . LYS A 1 106 ? -22.304 -16.963 -10.510 1.000 45.458  0 106 LYS A N   1 ? 
ATOM   835  C CA  . LYS A 1 106 ? -23.505 -16.804 -11.380 1.000 56.724  0 106 LYS A CA  1 ? 
ATOM   836  C C   . LYS A 1 106 ? -24.704 -17.506 -10.709 1.000 58.257  0 106 LYS A C   1 ? 
ATOM   837  O O   . LYS A 1 106 ? -25.829 -17.172 -11.081 1.000 61.188  0 106 LYS A O   1 ? 
ATOM   838  C CB  . LYS A 1 106 ? -23.250 -17.278 -12.819 1.000 56.801  0 106 LYS A CB  1 ? 
ATOM   839  C CG  . LYS A 1 106 ? -23.708 -18.694 -13.143 1.000 62.780  0 106 LYS A CG  1 ? 
ATOM   840  C CD  . LYS A 1 106 ? -23.143 -19.233 -14.429 1.000 68.467  0 106 LYS A CD  1 ? 
ATOM   841  C CE  . LYS A 1 106 ? -21.689 -19.640 -14.308 1.000 72.743  0 106 LYS A CE  1 ? 
ATOM   842  N NZ  . LYS A 1 106 ? -21.057 -19.774 -15.639 1.000 80.121  0 106 LYS A NZ  1 ? 
ATOM   843  N N   . ASP A 1 107 ? -24.472 -18.389 -9.724  1.000 62.448  0 107 ASP A N   1 ? 
ATOM   844  C CA  . ASP A 1 107 ? -25.540 -19.121 -8.986  1.000 64.795  0 107 ASP A CA  1 ? 
ATOM   845  C C   . ASP A 1 107 ? -25.497 -18.784 -7.488  1.000 67.003  0 107 ASP A C   1 ? 
ATOM   846  O O   . ASP A 1 107 ? -25.812 -19.675 -6.690  1.000 71.272  0 107 ASP A O   1 ? 
ATOM   847  C CB  . ASP A 1 107 ? -25.388 -20.637 -9.153  1.000 65.256  0 107 ASP A CB  1 ? 
ATOM   848  C CG  . ASP A 1 107 ? -25.103 -21.077 -10.576 1.000 72.326  0 107 ASP A CG  1 ? 
ATOM   849  O OD1 . ASP A 1 107 ? -25.680 -20.475 -11.506 1.000 76.103  0 107 ASP A OD1 1 ? 
ATOM   850  O OD2 . ASP A 1 107 ? -24.301 -22.011 -10.744 1.000 75.863  0 107 ASP A OD2 1 ? 
ATOM   851  N N   . TYR A 1 108 ? -25.086 -17.577 -7.103  1.000 61.988  0 108 TYR A N   1 ? 
ATOM   852  C CA  . TYR A 1 108 ? -25.036 -17.165 -5.679  1.000 53.461  0 108 TYR A CA  1 ? 
ATOM   853  C C   . TYR A 1 108 ? -25.895 -15.911 -5.505  1.000 58.310  0 108 TYR A C   1 ? 
ATOM   854  O O   . TYR A 1 108 ? -25.636 -14.868 -6.159  1.000 52.240  0 108 TYR A O   1 ? 
ATOM   855  C CB  . TYR A 1 108 ? -23.599 -17.010 -5.182  1.000 55.257  0 108 TYR A CB  1 ? 
ATOM   856  C CG  . TYR A 1 108 ? -23.508 -16.770 -3.696  1.000 55.155  0 108 TYR A CG  1 ? 
ATOM   857  C CD1 . TYR A 1 108 ? -23.571 -17.818 -2.788  1.000 53.309  0 108 TYR A CD1 1 ? 
ATOM   858  C CD2 . TYR A 1 108 ? -23.444 -15.484 -3.189  1.000 50.693  0 108 TYR A CD2 1 ? 
ATOM   859  C CE1 . TYR A 1 108 ? -23.544 -17.592 -1.417  1.000 48.898  0 108 TYR A CE1 1 ? 
ATOM   860  C CE2 . TYR A 1 108 ? -23.410 -15.241 -1.824  1.000 48.879  0 108 TYR A CE2 1 ? 
ATOM   861  C CZ  . TYR A 1 108 ? -23.459 -16.299 -0.932  1.000 50.673  0 108 TYR A CZ  1 ? 
ATOM   862  O OH  . TYR A 1 108 ? -23.419 -16.065 0.414   1.000 51.172  0 108 TYR A OH  1 ? 
ATOM   863  N N   . GLY A 1 109 ? -26.901 -16.020 -4.637  1.000 58.386  0 109 GLY A N   1 ? 
ATOM   864  C CA  . GLY A 1 109 ? -28.125 -15.206 -4.708  1.000 67.540  0 109 GLY A CA  1 ? 
ATOM   865  C C   . GLY A 1 109 ? -28.577 -15.064 -6.156  1.000 70.805  0 109 GLY A C   1 ? 
ATOM   866  O O   . GLY A 1 109 ? -28.608 -16.092 -6.892  1.000 66.467  0 109 GLY A O   1 ? 
ATOM   867  N N   . ASN A 1 110 ? -28.801 -13.824 -6.585  1.000 73.891  0 110 ASN A N   1 ? 
ATOM   868  C CA  . ASN A 1 110 ? -29.253 -13.462 -7.955  1.000 75.713  0 110 ASN A CA  1 ? 
ATOM   869  C C   . ASN A 1 110 ? -28.070 -13.483 -8.948  1.000 76.613  0 110 ASN A C   1 ? 
ATOM   870  O O   . ASN A 1 110 ? -28.329 -13.388 -10.160 1.000 77.594  0 110 ASN A O   1 ? 
ATOM   871  C CB  . ASN A 1 110 ? -29.939 -12.095 -7.926  1.000 80.236  0 110 ASN A CB  1 ? 
ATOM   872  C CG  . ASN A 1 110 ? -29.308 -11.181 -6.899  1.000 80.923  0 110 ASN A CG  1 ? 
ATOM   873  O OD1 . ASN A 1 110 ? -29.919 -10.878 -5.880  1.000 78.112  0 110 ASN A OD1 1 ? 
ATOM   874  N ND2 . ASN A 1 110 ? -28.046 -10.832 -7.107  1.000 88.203  0 110 ASN A ND2 1 ? 
ATOM   875  N N   . GLY A 1 111 ? -26.824 -13.588 -8.464  1.000 74.373  0 111 GLY A N   1 ? 
ATOM   876  C CA  . GLY A 1 111 ? -25.597 -13.453 -9.276  1.000 65.405  0 111 GLY A CA  1 ? 
ATOM   877  C C   . GLY A 1 111 ? -24.888 -12.132 -8.994  1.000 65.850  0 111 GLY A C   1 ? 
ATOM   878  O O   . GLY A 1 111 ? -25.407 -11.334 -8.136  1.000 64.446  0 111 GLY A O   1 ? 
ATOM   879  N N   . ALA A 1 112 ? -23.761 -11.889 -9.687  1.000 54.936  0 112 ALA A N   1 ? 
ATOM   880  C CA  . ALA A 1 112 ? -22.787 -10.799 -9.415  1.000 45.788  0 112 ALA A CA  1 ? 
ATOM   881  C C   . ALA A 1 112 ? -22.839 -9.728  -10.518 1.000 44.036  0 112 ALA A C   1 ? 
ATOM   882  O O   . ALA A 1 112 ? -23.275 -10.037 -11.620 1.000 41.684  0 112 ALA A O   1 ? 
ATOM   883  C CB  . ALA A 1 112 ? -21.406 -11.394 -9.305  1.000 45.420  0 112 ALA A CB  1 ? 
ATOM   884  N N   . GLU A 1 113 ? -22.361 -8.510  -10.263 1.000 38.549  0 113 GLU A N   1 ? 
ATOM   885  C CA  . GLU A 1 113 ? -22.060 -7.569  -11.372 1.000 38.946  0 113 GLU A CA  1 ? 
ATOM   886  C C   . GLU A 1 113 ? -20.595 -7.110  -11.276 1.000 38.980  0 113 GLU A C   1 ? 
ATOM   887  O O   . GLU A 1 113 ? -20.044 -6.988  -10.132 1.000 34.752  0 113 GLU A O   1 ? 
ATOM   888  C CB  . GLU A 1 113 ? -23.097 -6.450  -11.449 1.000 41.015  0 113 GLU A CB  1 ? 
ATOM   889  C CG  . GLU A 1 113 ? -23.075 -5.499  -10.293 1.000 49.822  0 113 GLU A CG  1 ? 
ATOM   890  C CD  . GLU A 1 113 ? -24.115 -4.397  -10.396 1.000 54.882  0 113 GLU A CD  1 ? 
ATOM   891  O OE1 . GLU A 1 113 ? -25.264 -4.702  -10.812 1.000 54.746  0 113 GLU A OE1 1 ? 
ATOM   892  O OE2 . GLU A 1 113 ? -23.768 -3.233  -10.067 1.000 55.892  0 113 GLU A OE2 1 ? 
ATOM   893  N N   . ILE A 1 114 ? -19.973 -6.927  -12.442 1.000 36.525  0 114 ILE A N   1 ? 
ATOM   894  C CA  . ILE A 1 114 ? -18.600 -6.368  -12.596 1.000 33.432  0 114 ILE A CA  1 ? 
ATOM   895  C C   . ILE A 1 114 ? -18.705 -4.855  -12.576 1.000 32.541  0 114 ILE A C   1 ? 
ATOM   896  O O   . ILE A 1 114 ? -19.199 -4.280  -13.538 1.000 38.203  0 114 ILE A O   1 ? 
ATOM   897  C CB  . ILE A 1 114 ? -17.924 -6.893  -13.869 1.000 32.630  0 114 ILE A CB  1 ? 
ATOM   898  C CG1 . ILE A 1 114 ? -17.831 -8.422  -13.821 1.000 36.597  0 114 ILE A CG1 1 ? 
ATOM   899  C CG2 . ILE A 1 114 ? -16.554 -6.249  -14.073 1.000 31.836  0 114 ILE A CG2 1 ? 
ATOM   900  C CD1 . ILE A 1 114 ? -17.498 -9.071  -15.158 1.000 39.966  0 114 ILE A CD1 1 ? 
ATOM   901  N N   . ARG A 1 115 ? -18.273 -4.237  -11.489 1.000 30.943  0 115 ARG A N   1 ? 
ATOM   902  C CA  . ARG A 1 115 ? -18.193 -2.774  -11.362 1.000 28.720  0 115 ARG A CA  1 ? 
ATOM   903  C C   . ARG A 1 115 ? -16.756 -2.347  -11.664 1.000 28.135  0 115 ARG A C   1 ? 
ATOM   904  O O   . ARG A 1 115 ? -15.940 -3.218  -11.893 1.000 24.952  0 115 ARG A O   1 ? 
ATOM   905  C CB  . ARG A 1 115 ? -18.677 -2.367  -9.976  1.000 33.642  0 115 ARG A CB  1 ? 
ATOM   906  C CG  . ARG A 1 115 ? -20.174 -2.564  -9.765  1.000 38.680  0 115 ARG A CG  1 ? 
ATOM   907  C CD  . ARG A 1 115 ? -20.518 -2.103  -8.367  1.000 41.966  0 115 ARG A CD  1 ? 
ATOM   908  N NE  . ARG A 1 115 ? -21.929 -2.173  -8.028  1.000 46.911  0 115 ARG A NE  1 ? 
ATOM   909  C CZ  . ARG A 1 115 ? -22.416 -1.917  -6.809  1.000 54.808  0 115 ARG A CZ  1 ? 
ATOM   910  N NH1 . ARG A 1 115 ? -23.713 -2.030  -6.570  1.000 56.685  0 115 ARG A NH1 1 ? 
ATOM   911  N NH2 . ARG A 1 115 ? -21.595 -1.593  -5.820  1.000 59.092  0 115 ARG A NH2 1 ? 
ATOM   912  N N   . ARG A 1 116 ? -16.482 -1.048  -11.684 1.000 28.314  0 116 ARG A N   1 ? 
ATOM   913  C CA  . ARG A 1 116 ? -15.177 -0.501  -12.123 1.000 30.958  0 116 ARG A CA  1 ? 
ATOM   914  C C   . ARG A 1 116 ? -14.075 -1.021  -11.197 1.000 24.805  0 116 ARG A C   1 ? 
ATOM   915  O O   . ARG A 1 116 ? -12.975 -1.280  -11.691 1.000 24.738  0 116 ARG A O   1 ? 
ATOM   916  C CB  . ARG A 1 116 ? -15.192 1.032   -12.130 1.000 37.838  0 116 ARG A CB  1 ? 
ATOM   917  C CG  . ARG A 1 116 ? -13.861 1.692   -12.505 1.000 44.019  0 116 ARG A CG  1 ? 
ATOM   918  C CD  . ARG A 1 116 ? -13.968 3.210   -12.713 1.000 49.895  0 116 ARG A CD  1 ? 
ATOM   919  N NE  . ARG A 1 116 ? -14.728 3.514   -13.932 1.000 57.824  0 116 ARG A NE  1 ? 
ATOM   920  C CZ  . ARG A 1 116 ? -16.002 3.935   -13.991 1.000 67.892  0 116 ARG A CZ  1 ? 
ATOM   921  N NH1 . ARG A 1 116 ? -16.565 4.110   -15.176 1.000 61.191  0 116 ARG A NH1 1 ? 
ATOM   922  N NH2 . ARG A 1 116 ? -16.712 4.172   -12.890 1.000 78.353  0 116 ARG A NH2 1 ? 
ATOM   923  N N   . SER A 1 117 ? -14.319 -1.078  -9.891  1.000 23.392  0 117 SER A N   1 ? 
ATOM   924  C CA  . SER A 1 117 ? -13.262 -1.382  -8.892  1.000 25.722  0 117 SER A CA  1 ? 
ATOM   925  C C   . SER A 1 117 ? -13.504 -2.692  -8.135  1.000 25.569  0 117 SER A C   1 ? 
ATOM   926  O O   . SER A 1 117 ? -12.650 -3.035  -7.274  1.000 23.196  0 117 SER A O   1 ? 
ATOM   927  C CB  . SER A 1 117 ? -13.100 -0.223  -7.958  1.000 26.568  0 117 SER A CB  1 ? 
ATOM   928  O OG  . SER A 1 117 ? -12.401 0.783   -8.624  1.000 31.176  0 117 SER A OG  1 ? 
ATOM   929  N N   . CYS A 1 118 ? -14.553 -3.437  -8.461  1.000 23.425  0 118 CYS A N   1 ? 
ATOM   930  C CA  . CYS A 1 118 ? -14.936 -4.637  -7.685  1.000 25.938  0 118 CYS A CA  1 ? 
ATOM   931  C C   . CYS A 1 118 ? -15.955 -5.466  -8.457  1.000 25.145  0 118 CYS A C   1 ? 
ATOM   932  O O   . CYS A 1 118 ? -16.506 -4.954  -9.432  1.000 24.119  0 118 CYS A O   1 ? 
ATOM   933  C CB  . CYS A 1 118 ? -15.460 -4.252  -6.300  1.000 25.178  0 118 CYS A CB  1 ? 
ATOM   934  S SG  . CYS A 1 118 ? -17.012 -3.314  -6.286  1.000 27.161  0 118 CYS A SG  1 ? 
ATOM   935  N N   . VAL A 1 119 ? -16.158 -6.704  -8.011  1.000 27.317  0 119 VAL A N   1 ? 
ATOM   936  C CA  . VAL A 1 119 ? -17.282 -7.611  -8.399  1.000 26.448  0 119 VAL A CA  1 ? 
ATOM   937  C C   . VAL A 1 119 ? -18.233 -7.671  -7.213  1.000 28.623  0 119 VAL A C   1 ? 
ATOM   938  O O   . VAL A 1 119 ? -17.777 -8.049  -6.114  1.000 32.937  0 119 VAL A O   1 ? 
ATOM   939  C CB  . VAL A 1 119 ? -16.773 -9.010  -8.768  1.000 26.344  0 119 VAL A CB  1 ? 
ATOM   940  C CG1 . VAL A 1 119 ? -17.936 -9.979  -9.006  1.000 28.170  0 119 VAL A CG1 1 ? 
ATOM   941  C CG2 . VAL A 1 119 ? -15.813 -8.985  -9.947  1.000 24.489  0 119 VAL A CG2 1 ? 
ATOM   942  N N   . THR A 1 120 ? -19.442 -7.153  -7.371  1.000 29.577  0 120 THR A N   1 ? 
ATOM   943  C CA  . THR A 1 120 ? -20.423 -7.017  -6.260  1.000 30.797  0 120 THR A CA  1 ? 
ATOM   944  C C   . THR A 1 120 ? -21.463 -8.151  -6.340  1.000 28.780  0 120 THR A C   1 ? 
ATOM   945  O O   . THR A 1 120 ? -21.992 -8.396  -7.442  1.000 31.557  0 120 THR A O   1 ? 
ATOM   946  C CB  . THR A 1 120 ? -21.065 -5.628  -6.275  1.000 34.471  0 120 THR A CB  1 ? 
ATOM   947  O OG1 . THR A 1 120 ? -20.045 -4.651  -6.017  1.000 32.973  0 120 THR A OG1 1 ? 
ATOM   948  C CG2 . THR A 1 120 ? -22.197 -5.519  -5.268  1.000 33.963  0 120 THR A CG2 1 ? 
ATOM   949  N N   . VAL A 1 121 ? -21.748 -8.827  -5.224  1.000 33.348  0 121 VAL A N   1 ? 
ATOM   950  C CA  . VAL A 1 121 ? -22.877 -9.813  -5.130  1.000 34.419  0 121 VAL A CA  1 ? 
ATOM   951  C C   . VAL A 1 121 ? -23.914 -9.273  -4.147  1.000 33.183  0 121 VAL A C   1 ? 
ATOM   952  O O   . VAL A 1 121 ? -23.538 -8.689  -3.131  1.000 34.096  0 121 VAL A O   1 ? 
ATOM   953  C CB  . VAL A 1 121 ? -22.414 -11.242 -4.793  1.000 41.207  0 121 VAL A CB  1 ? 
ATOM   954  C CG1 . VAL A 1 121 ? -21.238 -11.263 -3.861  1.000 43.529  0 121 VAL A CG1 1 ? 
ATOM   955  C CG2 . VAL A 1 121 ? -23.544 -12.092 -4.235  1.000 47.381  0 121 VAL A CG2 1 ? 
ATOM   956  N N   . PHE A 1 122 ? -25.174 -9.369  -4.523  1.000 32.696  0 122 PHE A N   1 ? 
ATOM   957  C CA  . PHE A 1 122 ? -26.324 -8.781  -3.809  1.000 36.491  0 122 PHE A CA  1 ? 
ATOM   958  C C   . PHE A 1 122 ? -27.011 -9.886  -3.036  1.000 39.298  0 122 PHE A C   1 ? 
ATOM   959  O O   . PHE A 1 122 ? -27.229 -10.991 -3.594  1.000 39.099  0 122 PHE A O   1 ? 
ATOM   960  C CB  . PHE A 1 122 ? -27.290 -8.136  -4.790  1.000 40.551  0 122 PHE A CB  1 ? 
ATOM   961  C CG  . PHE A 1 122 ? -26.672 -7.006  -5.561  1.000 44.322  0 122 PHE A CG  1 ? 
ATOM   962  C CD1 . PHE A 1 122 ? -26.672 -5.722  -5.038  1.000 43.836  0 122 PHE A CD1 1 ? 
ATOM   963  C CD2 . PHE A 1 122 ? -26.044 -7.242  -6.777  1.000 46.499  0 122 PHE A CD2 1 ? 
ATOM   964  C CE1 . PHE A 1 122 ? -26.080 -4.686  -5.741  1.000 49.855  0 122 PHE A CE1 1 ? 
ATOM   965  C CE2 . PHE A 1 122 ? -25.459 -6.200  -7.479  1.000 48.624  0 122 PHE A CE2 1 ? 
ATOM   966  C CZ  . PHE A 1 122 ? -25.472 -4.930  -6.954  1.000 45.699  0 122 PHE A CZ  1 ? 
ATOM   967  N N   . LYS A 1 123 ? -27.261 -9.621  -1.769  1.000 38.858  0 123 LYS A N   1 ? 
ATOM   968  C CA  . LYS A 1 123 ? -28.018 -10.525 -0.891  1.000 47.050  0 123 LYS A CA  1 ? 
ATOM   969  C C   . LYS A 1 123 ? -29.094 -9.677  -0.246  1.000 43.492  0 123 LYS A C   1 ? 
ATOM   970  O O   . LYS A 1 123 ? -29.018 -8.445  -0.292  1.000 38.413  0 123 LYS A O   1 ? 
ATOM   971  C CB  . LYS A 1 123 ? -27.074 -11.189 0.119   1.000 54.061  0 123 LYS A CB  1 ? 
ATOM   972  C CG  . LYS A 1 123 ? -25.926 -11.989 -0.490  1.000 58.542  0 123 LYS A CG  1 ? 
ATOM   973  C CD  . LYS A 1 123 ? -26.056 -13.489 -0.338  1.000 65.093  0 123 LYS A CD  1 ? 
ATOM   974  C CE  . LYS A 1 123 ? -27.297 -14.051 -0.989  1.000 74.422  0 123 LYS A CE  1 ? 
ATOM   975  N NZ  . LYS A 1 123 ? -27.399 -15.513 -0.764  1.000 84.242  0 123 LYS A NZ  1 ? 
ATOM   976  N N   . PRO A 1 124 ? -30.153 -10.297 0.313   1.000 46.318  0 124 PRO A N   1 ? 
ATOM   977  C CA  . PRO A 1 124 ? -31.106 -9.550  1.137   1.000 43.266  0 124 PRO A CA  1 ? 
ATOM   978  C C   . PRO A 1 124 ? -30.411 -8.748  2.265   1.000 39.905  0 124 PRO A C   1 ? 
ATOM   979  O O   . PRO A 1 124 ? -29.863 -9.333  3.169   1.000 36.356  0 124 PRO A O   1 ? 
ATOM   980  C CB  . PRO A 1 124 ? -32.047 -10.653 1.676   1.000 46.217  0 124 PRO A CB  1 ? 
ATOM   981  C CG  . PRO A 1 124 ? -31.932 -11.794 0.671   1.000 45.335  0 124 PRO A CG  1 ? 
ATOM   982  C CD  . PRO A 1 124 ? -30.527 -11.712 0.108   1.000 46.200  0 124 PRO A CD  1 ? 
ATOM   983  N N   . GLY A 1 125 ? -30.442 -7.411  2.176   1.000 38.489  0 125 GLY A N   1 ? 
ATOM   984  C CA  . GLY A 1 125 ? -30.041 -6.491  3.261   1.000 39.963  0 125 GLY A CA  1 ? 
ATOM   985  C C   . GLY A 1 125 ? -28.548 -6.161  3.256   1.000 39.277  0 125 GLY A C   1 ? 
ATOM   986  O O   . GLY A 1 125 ? -28.111 -5.388  4.135   1.000 35.986  0 125 GLY A O   1 ? 
ATOM   987  N N   . TYR A 1 126 ? -27.768 -6.723  2.331   1.000 40.390  0 126 TYR A N   1 ? 
ATOM   988  C CA  . TYR A 1 126 ? -26.321 -6.399  2.254   1.000 40.785  0 126 TYR A CA  1 ? 
ATOM   989  C C   . TYR A 1 126 ? -25.747 -6.773  0.889   1.000 34.597  0 126 TYR A C   1 ? 
ATOM   990  O O   . TYR A 1 126 ? -26.338 -7.559  0.136   1.000 31.496  0 126 TYR A O   1 ? 
ATOM   991  C CB  . TYR A 1 126 ? -25.584 -7.074  3.415   1.000 39.148  0 126 TYR A CB  1 ? 
ATOM   992  C CG  . TYR A 1 126 ? -25.480 -8.570  3.314   1.000 36.750  0 126 TYR A CG  1 ? 
ATOM   993  C CD1 . TYR A 1 126 ? -26.452 -9.406  3.835   1.000 35.369  0 126 TYR A CD1 1 ? 
ATOM   994  C CD2 . TYR A 1 126 ? -24.397 -9.142  2.690   1.000 34.898  0 126 TYR A CD2 1 ? 
ATOM   995  C CE1 . TYR A 1 126 ? -26.345 -10.777 3.735   1.000 35.292  0 126 TYR A CE1 1 ? 
ATOM   996  C CE2 . TYR A 1 126 ? -24.252 -10.508 2.615   1.000 40.072  0 126 TYR A CE2 1 ? 
ATOM   997  C CZ  . TYR A 1 126 ? -25.235 -11.338 3.132   1.000 39.954  0 126 TYR A CZ  1 ? 
ATOM   998  O OH  . TYR A 1 126 ? -25.065 -12.698 3.018   1.000 37.331  0 126 TYR A OH  1 ? 
ATOM   999  N N   . HIS A 1 127 ? -24.605 -6.195  0.556   1.000 31.896  0 127 HIS A N   1 ? 
ATOM   1000 C CA  . HIS A 1 127 ? -23.836 -6.630  -0.623  1.000 30.889  0 127 HIS A CA  1 ? 
ATOM   1001 C C   . HIS A 1 127 ? -22.387 -6.837  -0.230  1.000 26.655  0 127 HIS A C   1 ? 
ATOM   1002 O O   . HIS A 1 127 ? -21.967 -6.373  0.830   1.000 27.059  0 127 HIS A O   1 ? 
ATOM   1003 C CB  . HIS A 1 127 ? -24.071 -5.713  -1.830  1.000 39.679  0 127 HIS A CB  1 ? 
ATOM   1004 C CG  . HIS A 1 127 ? -23.704 -4.292  -1.636  1.000 40.540  0 127 HIS A CG  1 ? 
ATOM   1005 N ND1 . HIS A 1 127 ? -24.593 -3.367  -1.125  1.000 48.180  0 127 HIS A ND1 1 ? 
ATOM   1006 C CD2 . HIS A 1 127 ? -22.562 -3.627  -1.907  1.000 45.488  0 127 HIS A CD2 1 ? 
ATOM   1007 C CE1 . HIS A 1 127 ? -24.003 -2.185  -1.061  1.000 49.824  0 127 HIS A CE1 1 ? 
ATOM   1008 N NE2 . HIS A 1 127 ? -22.755 -2.319  -1.543  1.000 50.360  0 127 HIS A NE2 1 ? 
ATOM   1009 N N   . VAL A 1 128 ? -21.713 -7.634  -1.023  1.000 25.330  0 128 VAL A N   1 ? 
ATOM   1010 C CA  . VAL A 1 128 ? -20.295 -7.990  -0.838  1.000 28.595  0 128 VAL A CA  1 ? 
ATOM   1011 C C   . VAL A 1 128 ? -19.582 -7.433  -2.046  1.000 28.515  0 128 VAL A C   1 ? 
ATOM   1012 O O   . VAL A 1 128 ? -20.011 -7.761  -3.165  1.000 29.207  0 128 VAL A O   1 ? 
ATOM   1013 C CB  . VAL A 1 128 ? -20.092 -9.506  -0.681  1.000 29.097  0 128 VAL A CB  1 ? 
ATOM   1014 C CG1 . VAL A 1 128 ? -18.697 -9.837  -0.226  1.000 28.281  0 128 VAL A CG1 1 ? 
ATOM   1015 C CG2 . VAL A 1 128 ? -21.111 -10.088 0.289   1.000 29.506  0 128 VAL A CG2 1 ? 
ATOM   1016 N N   . ASP A 1 129 ? -18.635 -6.528  -1.803  1.000 26.815  0 129 ASP A N   1 ? 
ATOM   1017 C CA  . ASP A 1 129 ? -17.734 -5.946  -2.826  1.000 25.250  0 129 ASP A CA  1 ? 
ATOM   1018 C C   . ASP A 1 129 ? -16.428 -6.716  -2.735  1.000 22.258  0 129 ASP A C   1 ? 
ATOM   1019 O O   . ASP A 1 129 ? -15.758 -6.625  -1.685  1.000 23.866  0 129 ASP A O   1 ? 
ATOM   1020 C CB  . ASP A 1 129 ? -17.512 -4.449  -2.614  1.000 28.237  0 129 ASP A CB  1 ? 
ATOM   1021 C CG  . ASP A 1 129 ? -18.737 -3.590  -2.914  1.000 33.929  0 129 ASP A CG  1 ? 
ATOM   1022 O OD1 . ASP A 1 129 ? -19.673 -4.097  -3.588  1.000 31.710  0 129 ASP A OD1 1 ? 
ATOM   1023 O OD2 . ASP A 1 129 ? -18.763 -2.437  -2.447  1.000 33.164  0 129 ASP A OD2 1 ? 
ATOM   1024 N N   . LEU A 1 130 ? -16.145 -7.501  -3.756  1.000 21.018  0 130 LEU A N   1 ? 
ATOM   1025 C CA  . LEU A 1 130 ? -14.898 -8.252  -3.902  1.000 20.301  0 130 LEU A CA  1 ? 
ATOM   1026 C C   . LEU A 1 130 ? -13.953 -7.382  -4.727  1.000 19.500  0 130 LEU A C   1 ? 
ATOM   1027 O O   . LEU A 1 130 ? -14.158 -7.225  -5.957  1.000 20.079  0 130 LEU A O   1 ? 
ATOM   1028 C CB  . LEU A 1 130 ? -15.139 -9.605  -4.582  1.000 21.904  0 130 LEU A CB  1 ? 
ATOM   1029 C CG  . LEU A 1 130 ? -16.104 -10.581 -3.900  1.000 28.782  0 130 LEU A CG  1 ? 
ATOM   1030 C CD1 . LEU A 1 130 ? -16.113 -11.922 -4.623  1.000 31.859  0 130 LEU A CD1 1 ? 
ATOM   1031 C CD2 . LEU A 1 130 ? -15.741 -10.809 -2.455  1.000 31.250  0 130 LEU A CD2 1 ? 
ATOM   1032 N N   . ALA A 1 131 ? -12.942 -6.847  -4.092  1.000 18.266  0 131 ALA A N   1 ? 
ATOM   1033 C CA  . ALA A 1 131 ? -11.851 -6.156  -4.800  1.000 18.263  0 131 ALA A CA  1 ? 
ATOM   1034 C C   . ALA A 1 131 ? -10.872 -7.227  -5.228  1.000 16.862  0 131 ALA A C   1 ? 
ATOM   1035 O O   . ALA A 1 131 ? -10.477 -8.096  -4.379  1.000 17.856  0 131 ALA A O   1 ? 
ATOM   1036 C CB  . ALA A 1 131 ? -11.217 -5.078  -3.917  1.000 19.273  0 131 ALA A CB  1 ? 
ATOM   1037 N N   . VAL A 1 132 ? -10.468 -7.183  -6.483  1.000 17.650  0 132 VAL A N   1 ? 
ATOM   1038 C CA  . VAL A 1 132 ? -9.736  -8.299  -7.128  1.000 17.874  0 132 VAL A CA  1 ? 
ATOM   1039 C C   . VAL A 1 132 ? -8.337  -7.822  -7.454  1.000 19.048  0 132 VAL A C   1 ? 
ATOM   1040 O O   . VAL A 1 132 ? -8.226  -6.797  -8.193  1.000 18.727  0 132 VAL A O   1 ? 
ATOM   1041 C CB  . VAL A 1 132 ? -10.488 -8.714  -8.392  1.000 19.874  0 132 VAL A CB  1 ? 
ATOM   1042 C CG1 . VAL A 1 132 ? -9.721  -9.771  -9.153  1.000 21.404  0 132 VAL A CG1 1 ? 
ATOM   1043 C CG2 . VAL A 1 132 ? -11.906 -9.151  -8.088  1.000 22.283  0 132 VAL A CG2 1 ? 
ATOM   1044 N N   . TYR A 1 133 ? -7.326  -8.456  -6.876  1.000 18.364  0 133 TYR A N   1 ? 
ATOM   1045 C CA  . TYR A 1 133 ? -5.915  -8.051  -6.994  1.000 18.610  0 133 TYR A CA  1 ? 
ATOM   1046 C C   . TYR A 1 133 ? -5.127  -9.190  -7.640  1.000 21.036  0 133 TYR A C   1 ? 
ATOM   1047 O O   . TYR A 1 133 ? -5.530  -10.390 -7.527  1.000 22.792  0 133 TYR A O   1 ? 
ATOM   1048 C CB  . TYR A 1 133 ? -5.304  -7.698  -5.633  1.000 21.134  0 133 TYR A CB  1 ? 
ATOM   1049 C CG  . TYR A 1 133 ? -6.027  -6.635  -4.842  1.000 21.955  0 133 TYR A CG  1 ? 
ATOM   1050 C CD1 . TYR A 1 133 ? -7.134  -6.958  -4.070  1.000 20.837  0 133 TYR A CD1 1 ? 
ATOM   1051 C CD2 . TYR A 1 133 ? -5.615  -5.306  -4.872  1.000 21.696  0 133 TYR A CD2 1 ? 
ATOM   1052 C CE1 . TYR A 1 133 ? -7.822  -5.994  -3.355  1.000 22.822  0 133 TYR A CE1 1 ? 
ATOM   1053 C CE2 . TYR A 1 133 ? -6.292  -4.326  -4.159  1.000 22.934  0 133 TYR A CE2 1 ? 
ATOM   1054 C CZ  . TYR A 1 133 ? -7.383  -4.678  -3.374  1.000 24.236  0 133 TYR A CZ  1 ? 
ATOM   1055 O OH  . TYR A 1 133 ? -8.048  -3.736  -2.651  1.000 22.094  0 133 TYR A OH  1 ? 
ATOM   1056 N N   . ALA A 1 134 ? -4.031  -8.836  -8.295  1.000 19.773  0 134 ALA A N   1 ? 
ATOM   1057 C CA  . ALA A 1 134 ? -3.021  -9.781  -8.797  1.000 23.684  0 134 ALA A CA  1 ? 
ATOM   1058 C C   . ALA A 1 134 ? -2.015  -10.038 -7.683  1.000 26.189  0 134 ALA A C   1 ? 
ATOM   1059 O O   . ALA A 1 134 ? -1.834  -9.161  -6.819  1.000 27.239  0 134 ALA A O   1 ? 
ATOM   1060 C CB  . ALA A 1 134 ? -2.354  -9.232  -10.032 1.000 24.308  0 134 ALA A CB  1 ? 
ATOM   1061 N N   . ASP A 1 135 ? -1.306  -11.153 -7.740  1.000 27.751  0 135 ASP A N   1 ? 
ATOM   1062 C CA  . ASP A 1 135 ? -0.323  -11.458 -6.676  1.000 29.731  0 135 ASP A CA  1 ? 
ATOM   1063 C C   . ASP A 1 135 ? 0.882   -10.541 -6.853  1.000 25.352  0 135 ASP A C   1 ? 
ATOM   1064 O O   . ASP A 1 135 ? 1.435   -10.452 -7.939  1.000 29.125  0 135 ASP A O   1 ? 
ATOM   1065 C CB  . ASP A 1 135 ? 0.030   -12.945 -6.637  1.000 32.874  0 135 ASP A CB  1 ? 
ATOM   1066 C CG  . ASP A 1 135 ? 1.224   -13.174 -5.735  1.000 32.917  0 135 ASP A CG  1 ? 
ATOM   1067 O OD1 . ASP A 1 135 ? 2.344   -13.140 -6.234  1.000 41.981  0 135 ASP A OD1 1 ? 
ATOM   1068 O OD2 . ASP A 1 135 ? 1.037   -13.217 -4.550  1.000 37.842  0 135 ASP A OD2 1 ? 
ATOM   1069 N N   . PRO A 1 136 ? 1.332   -9.825  -5.799  1.000 26.498  0 136 PRO A N   1 ? 
ATOM   1070 C CA  . PRO A 1 136 ? 2.503   -8.968  -5.904  1.000 28.237  0 136 PRO A CA  1 ? 
ATOM   1071 C C   . PRO A 1 136 ? 3.780   -9.685  -6.344  1.000 33.930  0 136 PRO A C   1 ? 
ATOM   1072 O O   . PRO A 1 136 ? 4.446   -9.161  -7.178  1.000 32.120  0 136 PRO A O   1 ? 
ATOM   1073 C CB  . PRO A 1 136 ? 2.687   -8.416  -4.486  1.000 29.599  0 136 PRO A CB  1 ? 
ATOM   1074 C CG  . PRO A 1 136 ? 1.304   -8.499  -3.871  1.000 28.527  0 136 PRO A CG  1 ? 
ATOM   1075 C CD  . PRO A 1 136 ? 0.689   -9.739  -4.475  1.000 27.370  0 136 PRO A CD  1 ? 
ATOM   1076 N N   . GLU A 1 137 ? 4.096   -10.863 -5.786  1.000 35.132  0 137 GLU A N   1 ? 
ATOM   1077 C CA  . GLU A 1 137 ? 5.348   -11.592 -6.159  1.000 39.571  0 137 GLU A CA  1 ? 
ATOM   1078 C C   . GLU A 1 137 ? 5.288   -11.998 -7.643  1.000 35.344  0 137 GLU A C   1 ? 
ATOM   1079 O O   . GLU A 1 137 ? 6.256   -11.756 -8.342  1.000 40.502  0 137 GLU A O   1 ? 
ATOM   1080 C CB  . GLU A 1 137 ? 5.609   -12.787 -5.236  1.000 46.501  0 137 GLU A CB  1 ? 
ATOM   1081 C CG  . GLU A 1 137 ? 7.100   -13.103 -5.070  1.000 54.689  0 137 GLU A CG  1 ? 
ATOM   1082 C CD  . GLU A 1 137 ? 7.389   -14.532 -4.610  1.000 57.428  0 137 GLU A CD  1 ? 
ATOM   1083 O OE1 . GLU A 1 137 ? 6.697   -15.011 -3.675  1.000 60.673  0 137 GLU A OE1 1 ? 
ATOM   1084 O OE2 . GLU A 1 137 ? 8.259   -15.189 -5.220  1.000 54.906  0 137 GLU A OE2 1 ? 
ATOM   1085 N N   . LEU A 1 138 ? 4.147   -12.463 -8.149  1.000 35.984  0 138 LEU A N   1 ? 
ATOM   1086 C CA  . LEU A 1 138 ? 4.005   -12.825 -9.588  1.000 33.947  0 138 LEU A CA  1 ? 
ATOM   1087 C C   . LEU A 1 138 ? 3.940   -11.560 -10.469 1.000 38.282  0 138 LEU A C   1 ? 
ATOM   1088 O O   . LEU A 1 138 ? 4.037   -11.702 -11.698 1.000 39.556  0 138 LEU A O   1 ? 
ATOM   1089 C CB  . LEU A 1 138 ? 2.761   -13.701 -9.789  1.000 36.499  0 138 LEU A CB  1 ? 
ATOM   1090 C CG  . LEU A 1 138 ? 2.726   -15.043 -9.054  1.000 39.600  0 138 LEU A CG  1 ? 
ATOM   1091 C CD1 . LEU A 1 138 ? 1.435   -15.804 -9.357  1.000 37.879  0 138 LEU A CD1 1 ? 
ATOM   1092 C CD2 . LEU A 1 138 ? 3.946   -15.886 -9.401  1.000 41.073  0 138 LEU A CD2 1 ? 
ATOM   1093 N N   . SER A 1 139 ? 3.772   -10.371 -9.889  1.000 37.383  0 139 SER A N   1 ? 
ATOM   1094 C CA  . SER A 1 139 ? 3.361   -9.145  -10.625 1.000 36.007  0 139 SER A CA  1 ? 
ATOM   1095 C C   . SER A 1 139 ? 4.431   -8.064  -10.520 1.000 35.695  0 139 SER A C   1 ? 
ATOM   1096 O O   . SER A 1 139 ? 4.129   -6.924  -10.826 1.000 48.769  0 139 SER A O   1 ? 
ATOM   1097 C CB  . SER A 1 139 ? 2.050   -8.645  -10.111 1.000 30.289  0 139 SER A CB  1 ? 
ATOM   1098 O OG  . SER A 1 139 ? 1.019   -9.507  -10.513 1.000 30.133  0 139 SER A OG  1 ? 
ATOM   1099 N N   . GLY A 1 140 ? 5.621   -8.413  -10.048 1.000 38.969  0 140 GLY A N   1 ? 
ATOM   1100 C CA  . GLY A 1 140 ? 6.799   -7.529  -10.055 1.000 35.573  0 140 GLY A CA  1 ? 
ATOM   1101 C C   . GLY A 1 140 ? 6.945   -6.793  -8.752  1.000 37.719  0 140 GLY A C   1 ? 
ATOM   1102 O O   . GLY A 1 140 ? 7.763   -5.879  -8.688  1.000 38.502  0 140 GLY A O   1 ? 
ATOM   1103 N N   . GLY A 1 141 ? 6.141   -7.141  -7.752  1.000 32.260  0 141 GLY A N   1 ? 
ATOM   1104 C CA  . GLY A 1 141 ? 6.311   -6.604  -6.399  1.000 33.138  0 141 GLY A CA  1 ? 
ATOM   1105 C C   . GLY A 1 141 ? 5.224   -5.636  -5.972  1.000 34.860  0 141 GLY A C   1 ? 
ATOM   1106 O O   . GLY A 1 141 ? 5.216   -5.304  -4.795  1.000 38.301  0 141 GLY A O   1 ? 
ATOM   1107 N N   . THR A 1 142 ? 4.353   -5.157  -6.861  1.000 30.528  0 142 THR A N   1 ? 
ATOM   1108 C CA  . THR A 1 142 ? 3.308   -4.176  -6.462  1.000 30.708  0 142 THR A CA  1 ? 
ATOM   1109 C C   . THR A 1 142 ? 1.971   -4.893  -6.348  1.000 25.883  0 142 THR A C   1 ? 
ATOM   1110 O O   . THR A 1 142 ? 1.783   -5.938  -7.012  1.000 26.527  0 142 THR A O   1 ? 
ATOM   1111 C CB  . THR A 1 142 ? 3.248   -2.977  -7.419  1.000 32.352  0 142 THR A CB  1 ? 
ATOM   1112 O OG1 . THR A 1 142 ? 2.627   -3.415  -8.621  1.000 29.676  0 142 THR A OG1 1 ? 
ATOM   1113 C CG2 . THR A 1 142 ? 4.618   -2.413  -7.718  1.000 34.085  0 142 THR A CG2 1 ? 
ATOM   1114 N N   . LEU A 1 143 ? 1.085   -4.378  -5.503  1.000 23.913  0 143 LEU A N   1 ? 
ATOM   1115 C CA  . LEU A 1 143 ? -0.271  -4.926  -5.371  1.000 22.512  0 143 LEU A CA  1 ? 
ATOM   1116 C C   . LEU A 1 143 ? -1.208  -4.094  -6.244  1.000 23.463  0 143 LEU A C   1 ? 
ATOM   1117 O O   . LEU A 1 143 ? -1.422  -2.891  -5.934  1.000 25.230  0 143 LEU A O   1 ? 
ATOM   1118 C CB  . LEU A 1 143 ? -0.714  -4.896  -3.912  1.000 22.676  0 143 LEU A CB  1 ? 
ATOM   1119 C CG  . LEU A 1 143 ? -2.118  -5.446  -3.680  1.000 23.327  0 143 LEU A CG  1 ? 
ATOM   1120 C CD1 . LEU A 1 143 ? -2.139  -6.952  -3.841  1.000 23.954  0 143 LEU A CD1 1 ? 
ATOM   1121 C CD2 . LEU A 1 143 ? -2.624  -5.075  -2.306  1.000 27.037  0 143 LEU A CD2 1 ? 
ATOM   1122 N N   . CYS A 1 144 ? -1.751  -4.678  -7.292  1.000 21.110  0 144 CYS A N   1 ? 
ATOM   1123 C CA  . CYS A 1 144 ? -2.565  -3.924  -8.262  1.000 21.342  0 144 CYS A CA  1 ? 
ATOM   1124 C C   . CYS A 1 144 ? -3.998  -4.433  -8.243  1.000 19.419  0 144 CYS A C   1 ? 
ATOM   1125 O O   . CYS A 1 144 ? -4.202  -5.637  -8.185  1.000 22.400  0 144 CYS A O   1 ? 
ATOM   1126 C CB  . CYS A 1 144 ? -1.937  -3.969  -9.639  1.000 20.521  0 144 CYS A CB  1 ? 
ATOM   1127 S SG  . CYS A 1 144 ? -0.364  -3.073  -9.666  1.000 26.007  0 144 CYS A SG  1 ? 
ATOM   1128 N N   . ILE A 1 145 ? -4.952  -3.520  -8.264  1.000 19.556  0 145 ILE A N   1 ? 
ATOM   1129 C CA  . ILE A 1 145 ? -6.395  -3.848  -8.308  1.000 19.423  0 145 ILE A CA  1 ? 
ATOM   1130 C C   . ILE A 1 145 ? -6.850  -3.854  -9.776  1.000 21.137  0 145 ILE A C   1 ? 
ATOM   1131 O O   . ILE A 1 145 ? -6.268  -3.095  -10.611 1.000 20.409  0 145 ILE A O   1 ? 
ATOM   1132 C CB  . ILE A 1 145 ? -7.196  -2.895  -7.417  1.000 19.555  0 145 ILE A CB  1 ? 
ATOM   1133 C CG1 . ILE A 1 145 ? -8.603  -3.416  -7.145  1.000 19.425  0 145 ILE A CG1 1 ? 
ATOM   1134 C CG2 . ILE A 1 145 ? -7.240  -1.483  -7.977  1.000 21.927  0 145 ILE A CG2 1 ? 
ATOM   1135 C CD1 . ILE A 1 145 ? -9.366  -2.566  -6.139  1.000 22.368  0 145 ILE A CD1 1 ? 
ATOM   1136 N N   . ALA A 1 146 ? -7.804  -4.721  -10.087 1.000 20.086  0 146 ALA A N   1 ? 
ATOM   1137 C CA  . ALA A 1 146 ? -8.380  -4.907  -11.435 1.000 21.398  0 146 ALA A CA  1 ? 
ATOM   1138 C C   . ALA A 1 146 ? -9.407  -3.812  -11.675 1.000 21.180  0 146 ALA A C   1 ? 
ATOM   1139 O O   . ALA A 1 146 ? -10.489 -3.927  -11.093 1.000 19.095  0 146 ALA A O   1 ? 
ATOM   1140 C CB  . ALA A 1 146 ? -9.033  -6.272  -11.591 1.000 20.043  0 146 ALA A CB  1 ? 
ATOM   1141 N N   . LYS A 1 147 ? -9.093  -2.845  -12.549 1.000 19.300  0 147 LYS A N   1 ? 
ATOM   1142 C CA  . LYS A 1 147 ? -9.993  -1.708  -12.837 1.000 24.459  0 147 LYS A CA  1 ? 
ATOM   1143 C C   . LYS A 1 147 ? -10.591 -1.896  -14.222 1.000 21.641  0 147 LYS A C   1 ? 
ATOM   1144 O O   . LYS A 1 147 ? -9.898  -2.350  -15.108 1.000 24.867  0 147 LYS A O   1 ? 
ATOM   1145 C CB  . LYS A 1 147 ? -9.243  -0.374  -12.740 1.000 30.271  0 147 LYS A CB  1 ? 
ATOM   1146 C CG  . LYS A 1 147 ? -8.847  0.036   -11.338 1.000 35.237  0 147 LYS A CG  1 ? 
ATOM   1147 C CD  . LYS A 1 147 ? -9.975  0.610   -10.532 1.000 43.616  0 147 LYS A CD  1 ? 
ATOM   1148 C CE  . LYS A 1 147 ? -9.521  1.563   -9.440  1.000 48.533  0 147 LYS A CE  1 ? 
ATOM   1149 N NZ  . LYS A 1 147 ? -9.466  2.957   -9.947  1.000 52.134  0 147 LYS A NZ  1 ? 
ATOM   1150 N N   . GLY A 1 148 ? -11.841 -1.523  -14.386 1.000 26.609  0 148 GLY A N   1 ? 
ATOM   1151 C CA  . GLY A 1 148 ? -12.496 -1.434  -15.707 1.000 29.288  0 148 GLY A CA  1 ? 
ATOM   1152 C C   . GLY A 1 148 ? -13.760 -2.278  -15.759 1.000 31.293  0 148 GLY A C   1 ? 
ATOM   1153 O O   . GLY A 1 148 ? -13.856 -3.261  -14.976 1.000 25.884  0 148 GLY A O   1 ? 
ATOM   1154 N N   . LYS A 1 149 ? -14.691 -1.916  -16.645 1.000 31.439  0 149 LYS A N   1 ? 
ATOM   1155 C CA  . LYS A 1 149 ? -15.955 -2.661  -16.853 1.000 29.972  0 149 LYS A CA  1 ? 
ATOM   1156 C C   . LYS A 1 149 ? -15.851 -3.449  -18.146 1.000 31.011  0 149 LYS A C   1 ? 
ATOM   1157 O O   . LYS A 1 149 ? -14.927 -3.180  -18.963 1.000 28.784  0 149 LYS A O   1 ? 
ATOM   1158 C CB  . LYS A 1 149 ? -17.157 -1.722  -16.853 1.000 35.703  0 149 LYS A CB  1 ? 
ATOM   1159 C CG  . LYS A 1 149 ? -17.248 -0.789  -15.648 1.000 39.177  0 149 LYS A CG  1 ? 
ATOM   1160 C CD  . LYS A 1 149 ? -18.616 -0.740  -14.957 1.000 47.922  0 149 LYS A CD  1 ? 
ATOM   1161 C CE  . LYS A 1 149 ? -19.614 0.224   -15.567 1.000 53.479  0 149 LYS A CE  1 ? 
ATOM   1162 N NZ  . LYS A 1 149 ? -19.101 1.611   -15.572 1.000 57.905  0 149 LYS A NZ  1 ? 
ATOM   1163 N N   . GLU A 1 150 ? -16.759 -4.406  -18.313 1.000 29.395  0 150 GLU A N   1 ? 
ATOM   1164 C CA  . GLU A 1 150 ? -16.868 -5.264  -19.517 1.000 33.403  0 150 GLU A CA  1 ? 
ATOM   1165 C C   . GLU A 1 150 ? -17.125 -4.365  -20.722 1.000 28.916  0 150 GLU A C   1 ? 
ATOM   1166 O O   . GLU A 1 150 ? -17.798 -3.355  -20.565 1.000 29.544  0 150 GLU A O   1 ? 
ATOM   1167 C CB  . GLU A 1 150 ? -17.994 -6.278  -19.325 1.000 37.917  0 150 GLU A CB  1 ? 
ATOM   1168 C CG  . GLU A 1 150 ? -17.529 -7.592  -18.731 1.000 38.667  0 150 GLU A CG  1 ? 
ATOM   1169 C CD  . GLU A 1 150 ? -18.478 -8.742  -19.046 1.000 45.632  0 150 GLU A CD  1 ? 
ATOM   1170 O OE1 . GLU A 1 150 ? -18.159 -9.526  -19.975 1.000 48.732  0 150 GLU A OE1 1 ? 
ATOM   1171 O OE2 . GLU A 1 150 ? -19.568 -8.814  -18.401 1.000 36.720  0 150 GLU A OE2 1 ? 
ATOM   1172 N N   . ASN A 1 151 ? -16.517 -4.681  -21.849 1.000 32.106  0 151 ASN A N   1 ? 
ATOM   1173 C CA  . ASN A 1 151 ? -16.665 -3.908  -23.109 1.000 34.499  0 151 ASN A CA  1 ? 
ATOM   1174 C C   . ASN A 1 151 ? -16.197 -2.448  -22.937 1.000 35.711  0 151 ASN A C   1 ? 
ATOM   1175 O O   . ASN A 1 151 ? -16.497 -1.654  -23.805 1.000 37.787  0 151 ASN A O   1 ? 
ATOM   1176 C CB  . ASN A 1 151 ? -18.104 -4.018  -23.620 1.000 34.866  0 151 ASN A CB  1 ? 
ATOM   1177 C CG  . ASN A 1 151 ? -18.552 -5.460  -23.744 1.000 34.632  0 151 ASN A CG  1 ? 
ATOM   1178 O OD1 . ASN A 1 151 ? -17.870 -6.296  -24.366 1.000 30.783  0 151 ASN A OD1 1 ? 
ATOM   1179 N ND2 . ASN A 1 151 ? -19.687 -5.775  -23.147 1.000 36.254  0 151 ASN A ND2 1 ? 
ATOM   1180 N N   . SER A 1 152 ? -15.447 -2.108  -21.881 1.000 36.445  0 152 SER A N   1 ? 
ATOM   1181 C CA  . SER A 1 152 ? -14.783 -0.784  -21.696 1.000 34.903  0 152 SER A CA  1 ? 
ATOM   1182 C C   . SER A 1 152 ? -13.616 -0.640  -22.680 1.000 32.786  0 152 SER A C   1 ? 
ATOM   1183 O O   . SER A 1 152 ? -12.939 -1.633  -22.934 1.000 34.377  0 152 SER A O   1 ? 
ATOM   1184 C CB  . SER A 1 152 ? -14.265 -0.628  -20.284 1.000 38.410  0 152 SER A CB  1 ? 
ATOM   1185 O OG  . SER A 1 152 ? -13.213 -1.566  -20.037 1.000 29.270  0 152 SER A OG  1 ? 
ATOM   1186 N N   . GLY A 1 153 ? -13.338 0.567   -23.156 1.000 35.148  0 153 GLY A N   1 ? 
ATOM   1187 C CA  . GLY A 1 153 ? -12.160 0.817   -24.022 1.000 30.619  0 153 GLY A CA  1 ? 
ATOM   1188 C C   . GLY A 1 153 ? -10.857 0.585   -23.254 1.000 28.672  0 153 GLY A C   1 ? 
ATOM   1189 O O   . GLY A 1 153 ? -10.890 0.685   -22.020 1.000 27.775  0 153 GLY A O   1 ? 
ATOM   1190 N N   . ASP A 1 154 ? -9.748  0.348   -23.965 1.000 28.303  0 154 ASP A N   1 ? 
ATOM   1191 C CA  . ASP A 1 154 ? -8.436  -0.062  -23.397 1.000 33.838  0 154 ASP A CA  1 ? 
ATOM   1192 C C   . ASP A 1 154 ? -7.958  0.969   -22.358 1.000 34.021  0 154 ASP A C   1 ? 
ATOM   1193 O O   . ASP A 1 154 ? -7.328  0.563   -21.362 1.000 31.489  0 154 ASP A O   1 ? 
ATOM   1194 C CB  . ASP A 1 154 ? -7.391  -0.212  -24.506 1.000 40.309  0 154 ASP A CB  1 ? 
ATOM   1195 C CG  . ASP A 1 154 ? -7.514  -1.461  -25.360 1.000 42.156  0 154 ASP A CG  1 ? 
ATOM   1196 O OD1 . ASP A 1 154 ? -6.699  -1.578  -26.307 1.000 41.785  0 154 ASP A OD1 1 ? 
ATOM   1197 O OD2 . ASP A 1 154 ? -8.392  -2.311  -25.065 1.000 42.453  0 154 ASP A OD2 1 ? 
ATOM   1198 N N   . GLU A 1 155 ? -8.235  2.249   -22.591 1.000 32.151  0 155 GLU A N   1 ? 
ATOM   1199 C CA  . GLU A 1 155 ? -7.894  3.388   -21.697 1.000 38.536  0 155 GLU A CA  1 ? 
ATOM   1200 C C   . GLU A 1 155 ? -8.638  3.269   -20.366 1.000 40.124  0 155 GLU A C   1 ? 
ATOM   1201 O O   . GLU A 1 155 ? -8.164  3.828   -19.388 1.000 49.025  0 155 GLU A O   1 ? 
ATOM   1202 C CB  . GLU A 1 155 ? -8.294  4.713   -22.341 1.000 41.133  0 155 GLU A CB  1 ? 
ATOM   1203 C CG  . GLU A 1 155 ? -7.124  5.506   -22.862 1.000 49.169  0 155 GLU A CG  1 ? 
ATOM   1204 C CD  . GLU A 1 155 ? -7.477  6.884   -23.417 1.000 50.068  0 155 GLU A CD  1 ? 
ATOM   1205 O OE1 . GLU A 1 155 ? -8.530  7.461   -23.024 1.000 51.465  0 155 GLU A OE1 1 ? 
ATOM   1206 O OE2 . GLU A 1 155 ? -6.713  7.362   -24.257 1.000 48.993  0 155 GLU A OE2 1 ? 
ATOM   1207 N N   . HIS A 1 156 ? -9.797  2.628   -20.348 1.000 36.191  0 156 HIS A N   1 ? 
ATOM   1208 C CA  . HIS A 1 156 ? -10.697 2.616   -19.164 1.000 39.476  0 156 HIS A CA  1 ? 
ATOM   1209 C C   . HIS A 1 156 ? -10.545 1.310   -18.380 1.000 33.497  0 156 HIS A C   1 ? 
ATOM   1210 O O   . HIS A 1 156 ? -11.410 1.039   -17.567 1.000 36.263  0 156 HIS A O   1 ? 
ATOM   1211 C CB  . HIS A 1 156 ? -12.155 2.864   -19.593 1.000 44.269  0 156 HIS A CB  1 ? 
ATOM   1212 C CG  . HIS A 1 156 ? -12.325 4.146   -20.318 1.000 51.938  0 156 HIS A CG  1 ? 
ATOM   1213 N ND1 . HIS A 1 156 ? -12.292 4.214   -21.711 1.000 59.918  0 156 HIS A ND1 1 ? 
ATOM   1214 C CD2 . HIS A 1 156 ? -12.397 5.416   -19.866 1.000 54.539  0 156 HIS A CD2 1 ? 
ATOM   1215 C CE1 . HIS A 1 156 ? -12.400 5.471   -22.084 1.000 64.265  0 156 HIS A CE1 1 ? 
ATOM   1216 N NE2 . HIS A 1 156 ? -12.463 6.230   -20.969 1.000 66.208  0 156 HIS A NE2 1 ? 
ATOM   1217 N N   . ARG A 1 157 ? -9.491  0.535   -18.617 1.000 27.821  0 157 ARG A N   1 ? 
ATOM   1218 C CA  . ARG A 1 157 ? -9.205  -0.664  -17.814 1.000 27.799  0 157 ARG A CA  1 ? 
ATOM   1219 C C   . ARG A 1 157 ? -7.705  -0.701  -17.568 1.000 29.193  0 157 ARG A C   1 ? 
ATOM   1220 O O   . ARG A 1 157 ? -6.975  -0.354  -18.449 1.000 32.493  0 157 ARG A O   1 ? 
ATOM   1221 C CB  . ARG A 1 157 ? -9.749  -1.928  -18.494 1.000 28.456  0 157 ARG A CB  1 ? 
ATOM   1222 C CG  . ARG A 1 157 ? -9.123  -2.224  -19.843 1.000 29.637  0 157 ARG A CG  1 ? 
ATOM   1223 C CD  . ARG A 1 157 ? -9.650  -3.516  -20.420 1.000 30.783  0 157 ARG A CD  1 ? 
ATOM   1224 N NE  . ARG A 1 157 ? -11.019 -3.512  -20.909 1.000 28.377  0 157 ARG A NE  1 ? 
ATOM   1225 C CZ  . ARG A 1 157 ? -11.632 -4.610  -21.392 1.000 28.788  0 157 ARG A CZ  1 ? 
ATOM   1226 N NH1 . ARG A 1 157 ? -12.861 -4.530  -21.883 1.000 26.451  0 157 ARG A NH1 1 ? 
ATOM   1227 N NH2 . ARG A 1 157 ? -10.991 -5.776  -21.397 1.000 28.179  0 157 ARG A NH2 1 ? 
ATOM   1228 N N   . LEU A 1 158 ? -7.296  -1.054  -16.353 1.000 26.987  0 158 LEU A N   1 ? 
ATOM   1229 C CA  . LEU A 1 158 ? -5.882  -1.150  -15.963 1.000 25.219  0 158 LEU A CA  1 ? 
ATOM   1230 C C   . LEU A 1 158 ? -5.772  -1.981  -14.684 1.000 21.414  0 158 LEU A C   1 ? 
ATOM   1231 O O   . LEU A 1 158 ? -6.781  -2.182  -13.973 1.000 20.733  0 158 LEU A O   1 ? 
ATOM   1232 C CB  . LEU A 1 158 ? -5.318  0.261   -15.774 1.000 29.366  0 158 LEU A CB  1 ? 
ATOM   1233 C CG  . LEU A 1 158 ? -5.951  1.073   -14.639 1.000 30.754  0 158 LEU A CG  1 ? 
ATOM   1234 C CD1 . LEU A 1 158 ? -5.009  2.177   -14.138 1.000 32.646  0 158 LEU A CD1 1 ? 
ATOM   1235 C CD2 . LEU A 1 158 ? -7.277  1.679   -15.079 1.000 34.873  0 158 LEU A CD2 1 ? 
ATOM   1236 N N   . TRP A 1 159 ? -4.567  -2.400  -14.413 1.000 18.958  0 159 TRP A N   1 ? 
ATOM   1237 C CA  . TRP A 1 159 ? -4.107  -2.905  -13.113 1.000 20.988  0 159 TRP A CA  1 ? 
ATOM   1238 C C   . TRP A 1 159 ? -3.536  -1.713  -12.371 1.000 21.036  0 159 TRP A C   1 ? 
ATOM   1239 O O   . TRP A 1 159 ? -2.559  -1.204  -12.835 1.000 22.322  0 159 TRP A O   1 ? 
ATOM   1240 C CB  . TRP A 1 159 ? -3.077  -4.024  -13.341 1.000 22.150  0 159 TRP A CB  1 ? 
ATOM   1241 C CG  . TRP A 1 159 ? -3.671  -5.339  -13.777 1.000 20.906  0 159 TRP A CG  1 ? 
ATOM   1242 C CD1 . TRP A 1 159 ? -3.532  -5.935  -15.000 1.000 22.156  0 159 TRP A CD1 1 ? 
ATOM   1243 C CD2 . TRP A 1 159 ? -4.423  -6.271  -12.974 1.000 21.906  0 159 TRP A CD2 1 ? 
ATOM   1244 N NE1 . TRP A 1 159 ? -4.172  -7.144  -15.024 1.000 21.544  0 159 TRP A NE1 1 ? 
ATOM   1245 C CE2 . TRP A 1 159 ? -4.737  -7.381  -13.807 1.000 23.705  0 159 TRP A CE2 1 ? 
ATOM   1246 C CE3 . TRP A 1 159 ? -4.857  -6.295  -11.647 1.000 21.242  0 159 TRP A CE3 1 ? 
ATOM   1247 C CZ2 . TRP A 1 159 ? -5.453  -8.486  -13.352 1.000 22.890  0 159 TRP A CZ2 1 ? 
ATOM   1248 C CZ3 . TRP A 1 159 ? -5.576  -7.386  -11.199 1.000 22.162  0 159 TRP A CZ3 1 ? 
ATOM   1249 C CH2 . TRP A 1 159 ? -5.863  -8.465  -12.038 1.000 22.320  0 159 TRP A CH2 1 ? 
ATOM   1250 N N   . GLN A 1 160 ? -4.227  -1.202  -11.357 1.000 20.524  0 160 GLN A N   1 ? 
ATOM   1251 C CA  . GLN A 1 160 ? -3.852  0.075   -10.697 1.000 20.905  0 160 GLN A CA  1 ? 
ATOM   1252 C C   . GLN A 1 160 ? -3.177  -0.188  -9.357  1.000 19.959  0 160 GLN A C   1 ? 
ATOM   1253 O O   . GLN A 1 160 ? -3.750  -0.952  -8.543  1.000 20.021  0 160 GLN A O   1 ? 
ATOM   1254 C CB  . GLN A 1 160 ? -5.067  0.945   -10.427 1.000 23.843  0 160 GLN A CB  1 ? 
ATOM   1255 C CG  . GLN A 1 160 ? -4.634  2.303   -9.893  1.000 25.234  0 160 GLN A CG  1 ? 
ATOM   1256 C CD  . GLN A 1 160 ? -5.793  3.250   -9.821  1.000 27.310  0 160 GLN A CD  1 ? 
ATOM   1257 O OE1 . GLN A 1 160 ? -6.777  3.011   -9.129  1.000 23.843  0 160 GLN A OE1 1 ? 
ATOM   1258 N NE2 . GLN A 1 160 ? -5.658  4.350   -10.532 1.000 32.065  0 160 GLN A NE2 1 ? 
ATOM   1259 N N   . ILE A 1 161 ? -2.008  0.406   -9.134  1.000 22.108  0 161 ILE A N   1 ? 
ATOM   1260 C CA  . ILE A 1 161 ? -1.289  0.301   -7.840  1.000 23.412  0 161 ILE A CA  1 ? 
ATOM   1261 C C   . ILE A 1 161 ? -2.266  0.658   -6.713  1.000 21.354  0 161 ILE A C   1 ? 
ATOM   1262 O O   . ILE A 1 161 ? -3.053  1.605   -6.880  1.000 19.817  0 161 ILE A O   1 ? 
ATOM   1263 C CB  . ILE A 1 161 ? -0.039  1.186   -7.831  1.000 26.585  0 161 ILE A CB  1 ? 
ATOM   1264 C CG1 . ILE A 1 161 ? 0.774   0.952   -6.552  1.000 28.922  0 161 ILE A CG1 1 ? 
ATOM   1265 C CG2 . ILE A 1 161 ? -0.382  2.662   -8.036  1.000 28.345  0 161 ILE A CG2 1 ? 
ATOM   1266 C CD1 . ILE A 1 161 ? 2.276   1.030   -6.783  1.000 32.828  0 161 ILE A CD1 1 ? 
ATOM   1267 N N   . SER A 1 162 ? -2.244  -0.077  -5.607  1.000 20.450  0 162 SER A N   1 ? 
ATOM   1268 C CA  . SER A 1 162 ? -3.220  0.097   -4.503  1.000 22.804  0 162 SER A CA  1 ? 
ATOM   1269 C C   . SER A 1 162 ? -2.538  -0.264  -3.194  1.000 23.925  0 162 SER A C   1 ? 
ATOM   1270 O O   . SER A 1 162 ? -1.494  -0.938  -3.247  1.000 24.671  0 162 SER A O   1 ? 
ATOM   1271 C CB  . SER A 1 162 ? -4.470  -0.702  -4.752  1.000 25.359  0 162 SER A CB  1 ? 
ATOM   1272 O OG  . SER A 1 162 ? -4.169  -2.079  -4.686  1.000 35.988  0 162 SER A OG  1 ? 
ATOM   1273 N N   . ASP A 1 163 ? -3.045  0.236   -2.073  1.000 20.060  0 163 ASP A N   1 ? 
ATOM   1274 C CA  . ASP A 1 163 ? -2.428  -0.037  -0.756  1.000 22.343  0 163 ASP A CA  1 ? 
ATOM   1275 C C   . ASP A 1 163 ? -3.515  -0.056  0.317   1.000 21.918  0 163 ASP A C   1 ? 
ATOM   1276 O O   . ASP A 1 163 ? -3.479  0.744   1.249   1.000 19.288  0 163 ASP A O   1 ? 
ATOM   1277 C CB  . ASP A 1 163 ? -1.336  0.977   -0.494  1.000 21.760  0 163 ASP A CB  1 ? 
ATOM   1278 C CG  . ASP A 1 163 ? -0.562  0.709   0.757   1.000 23.198  0 163 ASP A CG  1 ? 
ATOM   1279 O OD1 . ASP A 1 163 ? -0.702  -0.375  1.287   1.000 22.731  0 163 ASP A OD1 1 ? 
ATOM   1280 O OD2 . ASP A 1 163 ? 0.177   1.629   1.175   1.000 27.649  0 163 ASP A OD2 1 ? 
ATOM   1281 N N   . PRO A 1 164 ? -4.529  -0.945  0.186   1.000 22.264  0 164 PRO A N   1 ? 
ATOM   1282 C CA  . PRO A 1 164 ? -5.652  -0.986  1.130   1.000 21.307  0 164 PRO A CA  1 ? 
ATOM   1283 C C   . PRO A 1 164 ? -5.158  -1.237  2.560   1.000 23.459  0 164 PRO A C   1 ? 
ATOM   1284 O O   . PRO A 1 164 ? -5.609  -0.566  3.463   1.000 21.672  0 164 PRO A O   1 ? 
ATOM   1285 C CB  . PRO A 1 164 ? -6.553  -2.106  0.585   1.000 21.537  0 164 PRO A CB  1 ? 
ATOM   1286 C CG  . PRO A 1 164 ? -5.605  -2.966  -0.238  1.000 22.547  0 164 PRO A CG  1 ? 
ATOM   1287 C CD  . PRO A 1 164 ? -4.649  -1.960  -0.868  1.000 22.057  0 164 PRO A CD  1 ? 
ATOM   1288 N N   . GLN A 1 165 ? -4.133  -2.063  2.729   1.000 23.541  0 165 GLN A N   1 ? 
ATOM   1289 C CA  . GLN A 1 165 ? -3.603  -2.373  4.078   1.000 25.824  0 165 GLN A CA  1 ? 
ATOM   1290 C C   . GLN A 1 165 ? -2.922  -1.138  4.655   1.000 23.014  0 165 GLN A C   1 ? 
ATOM   1291 O O   . GLN A 1 165 ? -3.088  -0.914  5.866   1.000 20.940  0 165 GLN A O   1 ? 
ATOM   1292 C CB  . GLN A 1 165 ? -2.648  -3.581  4.093   1.000 30.418  0 165 GLN A CB  1 ? 
ATOM   1293 C CG  . GLN A 1 165 ? -2.486  -4.202  5.481   1.000 37.332  0 165 GLN A CG  1 ? 
ATOM   1294 C CD  . GLN A 1 165 ? -3.800  -4.562  6.156   1.000 42.003  0 165 GLN A CD  1 ? 
ATOM   1295 O OE1 . GLN A 1 165 ? -4.162  -4.002  7.201   1.000 46.118  0 165 GLN A OE1 1 ? 
ATOM   1296 N NE2 . GLN A 1 165 ? -4.549  -5.479  5.550   1.000 44.840  0 165 GLN A NE2 1 ? 
ATOM   1297 N N   . GLY A 1 166 ? -2.177  -0.374  3.845   1.000 20.995  0 166 GLY A N   1 ? 
ATOM   1298 C CA  . GLY A 1 166 ? -1.494  0.844   4.323   1.000 21.404  0 166 GLY A CA  1 ? 
ATOM   1299 C C   . GLY A 1 166 ? -2.511  1.919   4.720   1.000 19.230  0 166 GLY A C   1 ? 
ATOM   1300 O O   . GLY A 1 166 ? -2.328  2.614   5.718   1.000 19.897  0 166 GLY A O   1 ? 
ATOM   1301 N N   . PHE A 1 167 ? -3.583  2.027   3.982   1.000 18.658  0 167 PHE A N   1 ? 
ATOM   1302 C CA  . PHE A 1 167 ? -4.678  2.954   4.337   1.000 18.798  0 167 PHE A CA  1 ? 
ATOM   1303 C C   . PHE A 1 167 ? -5.251  2.553   5.703   1.000 19.364  0 167 PHE A C   1 ? 
ATOM   1304 O O   . PHE A 1 167 ? -5.389  3.418   6.612   1.000 19.732  0 167 PHE A O   1 ? 
ATOM   1305 C CB  . PHE A 1 167 ? -5.765  2.938   3.278   1.000 19.561  0 167 PHE A CB  1 ? 
ATOM   1306 C CG  . PHE A 1 167 ? -6.867  3.897   3.599   1.000 20.930  0 167 PHE A CG  1 ? 
ATOM   1307 C CD1 . PHE A 1 167 ? -6.619  5.249   3.683   1.000 22.834  0 167 PHE A CD1 1 ? 
ATOM   1308 C CD2 . PHE A 1 167 ? -8.135  3.443   3.894   1.000 25.665  0 167 PHE A CD2 1 ? 
ATOM   1309 C CE1 . PHE A 1 167 ? -7.631  6.140   4.029   1.000 22.358  0 167 PHE A CE1 1 ? 
ATOM   1310 C CE2 . PHE A 1 167 ? -9.137  4.333   4.242   1.000 22.843  0 167 PHE A CE2 1 ? 
ATOM   1311 C CZ  . PHE A 1 167 ? -8.889  5.671   4.301   1.000 20.102  0 167 PHE A CZ  1 ? 
ATOM   1312 N N   . GLN A 1 168 ? -5.567  1.271   5.856   1.000 20.978  0 168 GLN A N   1 ? 
ATOM   1313 C CA  . GLN A 1 168 ? -6.114  0.697   7.119   1.000 22.659  0 168 GLN A CA  1 ? 
ATOM   1314 C C   . GLN A 1 168 ? -5.151  0.973   8.261   1.000 20.043  0 168 GLN A C   1 ? 
ATOM   1315 O O   . GLN A 1 168 ? -5.616  1.391   9.361   1.000 19.284  0 168 GLN A O   1 ? 
ATOM   1316 C CB  . GLN A 1 168 ? -6.393  -0.797  6.985   1.000 24.526  0 168 GLN A CB  1 ? 
ATOM   1317 C CG  . GLN A 1 168 ? -7.556  -1.122  6.069   1.000 29.504  0 168 GLN A CG  1 ? 
ATOM   1318 C CD  . GLN A 1 168 ? -7.724  -2.616  5.854   1.000 34.585  0 168 GLN A CD  1 ? 
ATOM   1319 O OE1 . GLN A 1 168 ? -7.434  -3.447  6.725   1.000 38.710  0 168 GLN A OE1 1 ? 
ATOM   1320 N NE2 . GLN A 1 168 ? -8.187  -2.964  4.677   1.000 36.097  0 168 GLN A NE2 1 ? 
ATOM   1321 N N   . ASP A 1 169 ? -3.861  0.807   8.026   1.000 22.436  0 169 ASP A N   1 ? 
ATOM   1322 C CA  . ASP A 1 169 ? -2.838  0.986   9.088   1.000 25.092  0 169 ASP A CA  1 ? 
ATOM   1323 C C   . ASP A 1 169 ? -2.749  2.472   9.448   1.000 23.246  0 169 ASP A C   1 ? 
ATOM   1324 O O   . ASP A 1 169 ? -2.556  2.767   10.635  1.000 24.320  0 169 ASP A O   1 ? 
ATOM   1325 C CB  . ASP A 1 169 ? -1.472  0.424   8.678   1.000 27.241  0 169 ASP A CB  1 ? 
ATOM   1326 C CG  . ASP A 1 169 ? -1.442  -1.091  8.463   1.000 32.697  0 169 ASP A CG  1 ? 
ATOM   1327 O OD1 . ASP A 1 169 ? -0.464  -1.563  7.829   1.000 35.892  0 169 ASP A OD1 1 ? 
ATOM   1328 O OD2 . ASP A 1 169 ? -2.413  -1.799  8.890   1.000 31.900  0 169 ASP A OD2 1 ? 
ATOM   1329 N N   . ARG A 1 170 ? -2.903  3.368   8.470   1.000 22.661  0 170 ARG A N   1 ? 
ATOM   1330 C CA  . ARG A 1 170 ? -2.871  4.836   8.705   1.000 25.959  0 170 ARG A CA  1 ? 
ATOM   1331 C C   . ARG A 1 170 ? -4.030  5.235   9.625   1.000 21.507  0 170 ARG A C   1 ? 
ATOM   1332 O O   . ARG A 1 170 ? -3.843  6.078   10.507  1.000 20.765  0 170 ARG A O   1 ? 
ATOM   1333 C CB  . ARG A 1 170 ? -3.011  5.623   7.402   1.000 31.965  0 170 ARG A CB  1 ? 
ATOM   1334 C CG  . ARG A 1 170 ? -1.769  5.658   6.529   1.000 36.660  0 170 ARG A CG  1 ? 
ATOM   1335 C CD  . ARG A 1 170 ? -0.650  6.504   7.076   1.000 44.398  0 170 ARG A CD  1 ? 
ATOM   1336 N NE  . ARG A 1 170 ? 0.060   7.158   5.987   1.000 50.374  0 170 ARG A NE  1 ? 
ATOM   1337 C CZ  . ARG A 1 170 ? 0.810   6.533   5.078   1.000 54.121  0 170 ARG A CZ  1 ? 
ATOM   1338 N NH1 . ARG A 1 170 ? 1.397   7.236   4.127   1.000 64.255  0 170 ARG A NH1 1 ? 
ATOM   1339 N NH2 . ARG A 1 170 ? 0.977   5.221   5.112   1.000 53.869  0 170 ARG A NH2 1 ? 
ATOM   1340 N N   . ILE A 1 171 ? -5.217  4.745   9.329   1.000 19.949  0 171 ILE A N   1 ? 
ATOM   1341 C CA  . ILE A 1 171 ? -6.431  5.027   10.143  1.000 19.495  0 171 ILE A CA  1 ? 
ATOM   1342 C C   . ILE A 1 171 ? -6.217  4.443   11.550  1.000 20.417  0 171 ILE A C   1 ? 
ATOM   1343 O O   . ILE A 1 171 ? -6.452  5.167   12.506  1.000 20.171  0 171 ILE A O   1 ? 
ATOM   1344 C CB  . ILE A 1 171 ? -7.682  4.464   9.454   1.000 18.327  0 171 ILE A CB  1 ? 
ATOM   1345 C CG1 . ILE A 1 171 ? -7.896  5.106   8.082   1.000 19.340  0 171 ILE A CG1 1 ? 
ATOM   1346 C CG2 . ILE A 1 171 ? -8.908  4.613   10.339  1.000 18.880  0 171 ILE A CG2 1 ? 
ATOM   1347 C CD1 . ILE A 1 171 ? -7.981  6.611   8.120   1.000 19.483  0 171 ILE A CD1 1 ? 
ATOM   1348 N N   . ALA A 1 172 ? -5.719  3.207   11.677  1.000 19.821  0 172 ALA A N   1 ? 
ATOM   1349 C CA  . ALA A 1 172 ? -5.561  2.546   13.007  1.000 21.468  0 172 ALA A CA  1 ? 
ATOM   1350 C C   . ALA A 1 172 ? -4.548  3.308   13.860  1.000 21.915  0 172 ALA A C   1 ? 
ATOM   1351 O O   . ALA A 1 172 ? -4.755  3.440   15.079  1.000 20.344  0 172 ALA A O   1 ? 
ATOM   1352 C CB  . ALA A 1 172 ? -5.126  1.097   12.854  1.000 25.112  0 172 ALA A CB  1 ? 
ATOM   1353 N N   . SER A 1 173 ? -3.480  3.795   13.247  1.000 22.597  0 173 SER A N   1 ? 
ATOM   1354 C CA  . SER A 1 173 ? -2.308  4.272   14.001  1.000 25.865  0 173 SER A CA  1 ? 
ATOM   1355 C C   . SER A 1 173 ? -2.351  5.793   14.144  1.000 25.325  0 173 SER A C   1 ? 
ATOM   1356 O O   . SER A 1 173 ? -1.509  6.321   14.855  1.000 25.922  0 173 SER A O   1 ? 
ATOM   1357 C CB  . SER A 1 173 ? -1.038  3.779   13.370  1.000 26.456  0 173 SER A CB  1 ? 
ATOM   1358 O OG  . SER A 1 173 ? -0.845  4.460   12.167  1.000 30.863  0 173 SER A OG  1 ? 
ATOM   1359 N N   . LYS A 1 174 ? -3.325  6.494   13.553  1.000 24.153  0 174 LYS A N   1 ? 
ATOM   1360 C CA  . LYS A 1 174 ? -3.412  7.978   13.696  1.000 22.737  0 174 LYS A CA  1 ? 
ATOM   1361 C C   . LYS A 1 174 ? -3.451  8.379   15.177  1.000 22.575  0 174 LYS A C   1 ? 
ATOM   1362 O O   . LYS A 1 174 ? -2.848  9.390   15.522  1.000 22.818  0 174 LYS A O   1 ? 
ATOM   1363 C CB  . LYS A 1 174 ? -4.664  8.537   13.027  1.000 23.514  0 174 LYS A CB  1 ? 
ATOM   1364 C CG  . LYS A 1 174 ? -4.673  10.052  12.925  1.000 23.258  0 174 LYS A CG  1 ? 
ATOM   1365 C CD  . LYS A 1 174 ? -5.949  10.595  12.386  1.000 23.973  0 174 LYS A CD  1 ? 
ATOM   1366 C CE  . LYS A 1 174 ? -6.081  12.087  12.633  1.000 25.737  0 174 LYS A CE  1 ? 
ATOM   1367 N NZ  . LYS A 1 174 ? -5.071  12.848  11.863  1.000 24.803  0 174 LYS A NZ  1 ? 
ATOM   1368 N N   . LEU A 1 175 ? -4.279  7.691   15.967  1.000 20.848  0 175 LEU A N   1 ? 
ATOM   1369 C CA  . LEU A 1 175 ? -4.494  7.957   17.407  1.000 21.297  0 175 LEU A CA  1 ? 
ATOM   1370 C C   . LEU A 1 175 ? -4.568  6.626   18.112  1.000 20.158  0 175 LEU A C   1 ? 
ATOM   1371 O O   . LEU A 1 175 ? -4.636  5.606   17.421  1.000 19.761  0 175 LEU A O   1 ? 
ATOM   1372 C CB  . LEU A 1 175 ? -5.801  8.755   17.619  1.000 20.369  0 175 LEU A CB  1 ? 
ATOM   1373 C CG  . LEU A 1 175 ? -5.800  10.197  17.104  1.000 20.593  0 175 LEU A CG  1 ? 
ATOM   1374 C CD1 . LEU A 1 175 ? -7.205  10.719  16.922  1.000 21.690  0 175 LEU A CD1 1 ? 
ATOM   1375 C CD2 . LEU A 1 175 ? -5.030  11.125  18.053  1.000 22.344  0 175 LEU A CD2 1 ? 
ATOM   1376 N N   . SER A 1 176 ? -4.595  6.639   19.436  1.000 22.181  0 176 SER A N   1 ? 
ATOM   1377 C CA  . SER A 1 176 ? -4.805  5.422   20.249  1.000 23.982  0 176 SER A CA  1 ? 
ATOM   1378 C C   . SER A 1 176 ? -5.732  5.710   21.419  1.000 21.575  0 176 SER A C   1 ? 
ATOM   1379 O O   . SER A 1 176 ? -6.065  6.903   21.676  1.000 20.315  0 176 SER A O   1 ? 
ATOM   1380 C CB  . SER A 1 176 ? -3.476  4.870   20.713  1.000 28.563  0 176 SER A CB  1 ? 
ATOM   1381 O OG  . SER A 1 176 ? -2.845  5.830   21.507  1.000 32.025  0 176 SER A OG  1 ? 
ATOM   1382 N N   . GLY A 1 177 ? -6.163  4.636   22.071  1.000 23.998  0 177 GLY A N   1 ? 
ATOM   1383 C CA  . GLY A 1 177 ? -6.979  4.671   23.298  1.000 22.692  0 177 GLY A CA  1 ? 
ATOM   1384 C C   . GLY A 1 177 ? -8.259  5.483   23.120  1.000 23.341  0 177 GLY A C   1 ? 
ATOM   1385 O O   . GLY A 1 177 ? -8.942  5.334   22.049  1.000 21.316  0 177 GLY A O   1 ? 
ATOM   1386 N N   . ASP A 1 178 ? -8.582  6.295   24.121  1.000 21.036  0 178 ASP A N   1 ? 
ATOM   1387 C CA  . ASP A 1 178 ? -9.838  7.073   24.176  1.000 21.673  0 178 ASP A CA  1 ? 
ATOM   1388 C C   . ASP A 1 178 ? -9.816  8.104   23.040  1.000 21.060  0 178 ASP A C   1 ? 
ATOM   1389 O O   . ASP A 1 178 ? -10.907 8.438   22.543  1.000 22.530  0 178 ASP A O   1 ? 
ATOM   1390 C CB  . ASP A 1 178 ? -10.050 7.706   25.544  1.000 22.376  0 178 ASP A CB  1 ? 
ATOM   1391 C CG  . ASP A 1 178 ? -10.259 6.666   26.649  1.000 27.711  0 178 ASP A CG  1 ? 
ATOM   1392 O OD1 . ASP A 1 178 ? -10.495 5.490   26.319  1.000 27.478  0 178 ASP A OD1 1 ? 
ATOM   1393 O OD2 . ASP A 1 178 ? -10.095 7.020   27.808  1.000 32.280  0 178 ASP A OD2 1 ? 
ATOM   1394 N N   . ASP A 1 179 ? -8.648  8.604   22.645  1.000 19.513  0 179 ASP A N   1 ? 
ATOM   1395 C CA  . ASP A 1 179 ? -8.567  9.554   21.503  1.000 18.217  0 179 ASP A CA  1 ? 
ATOM   1396 C C   . ASP A 1 179 ? -9.048  8.866   20.218  1.000 17.337  0 179 ASP A C   1 ? 
ATOM   1397 O O   . ASP A 1 179 ? -9.852  9.507   19.472  1.000 18.024  0 179 ASP A O   1 ? 
ATOM   1398 C CB  . ASP A 1 179 ? -7.187  10.195  21.320  1.000 18.922  0 179 ASP A CB  1 ? 
ATOM   1399 C CG  . ASP A 1 179 ? -6.834  11.256  22.367  1.000 19.959  0 179 ASP A CG  1 ? 
ATOM   1400 O OD1 . ASP A 1 179 ? -7.656  11.530  23.280  1.000 22.627  0 179 ASP A OD1 1 ? 
ATOM   1401 O OD2 . ASP A 1 179 ? -5.711  11.735  22.302  1.000 24.408  0 179 ASP A OD2 1 ? 
ATOM   1402 N N   . ALA A 1 180 ? -8.535  7.659   19.922  1.000 17.212  0 180 ALA A N   1 ? 
ATOM   1403 C CA  . ALA A 1 180 ? -8.866  6.912   18.704  1.000 16.303  0 180 ALA A CA  1 ? 
ATOM   1404 C C   . ALA A 1 180 ? -10.358 6.579   18.748  1.000 17.920  0 180 ALA A C   1 ? 
ATOM   1405 O O   . ALA A 1 180 ? -10.994 6.608   17.669  1.000 16.429  0 180 ALA A O   1 ? 
ATOM   1406 C CB  . ALA A 1 180 ? -8.005  5.682   18.533  1.000 15.528  0 180 ALA A CB  1 ? 
ATOM   1407 N N   . ALA A 1 181 ? -10.903 6.279   19.940  1.000 18.748  0 181 ALA A N   1 ? 
ATOM   1408 C CA  . ALA A 1 181 ? -12.334 5.968   20.097  1.000 18.109  0 181 ALA A CA  1 ? 
ATOM   1409 C C   . ALA A 1 181 ? -13.155 7.170   19.599  1.000 17.524  0 181 ALA A C   1 ? 
ATOM   1410 O O   . ALA A 1 181 ? -14.092 6.954   18.830  1.000 17.958  0 181 ALA A O   1 ? 
ATOM   1411 C CB  . ALA A 1 181 ? -12.645 5.605   21.528  1.000 20.171  0 181 ALA A CB  1 ? 
ATOM   1412 N N   . GLN A 1 182 ? -12.807 8.405   19.977  1.000 16.808  0 182 GLN A N   1 ? 
ATOM   1413 C CA  . GLN A 1 182 ? -13.560 9.606   19.505  1.000 17.246  0 182 GLN A CA  1 ? 
ATOM   1414 C C   . GLN A 1 182 ? -13.462 9.745   17.978  1.000 17.175  0 182 GLN A C   1 ? 
ATOM   1415 O O   . GLN A 1 182 ? -14.454 10.088  17.321  1.000 17.859  0 182 GLN A O   1 ? 
ATOM   1416 C CB  . GLN A 1 182 ? -13.063 10.887  20.162  1.000 17.866  0 182 GLN A CB  1 ? 
ATOM   1417 C CG  . GLN A 1 182 ? -14.015 12.047  19.912  1.000 17.145  0 182 GLN A CG  1 ? 
ATOM   1418 C CD  . GLN A 1 182 ? -13.543 13.348  20.490  1.000 17.613  0 182 GLN A CD  1 ? 
ATOM   1419 O OE1 . GLN A 1 182 ? -12.395 13.737  20.330  1.000 17.521  0 182 GLN A OE1 1 ? 
ATOM   1420 N NE2 . GLN A 1 182 ? -14.458 14.058  21.126  1.000 18.520  0 182 GLN A NE2 1 ? 
ATOM   1421 N N   . PHE A 1 183 ? -12.272 9.553   17.431  1.000 17.930  0 183 PHE A N   1 ? 
ATOM   1422 C CA  . PHE A 1 183 ? -12.005 9.589   15.983  1.000 17.660  0 183 PHE A CA  1 ? 
ATOM   1423 C C   . PHE A 1 183 ? -12.982 8.618   15.294  1.000 17.357  0 183 PHE A C   1 ? 
ATOM   1424 O O   . PHE A 1 183 ? -13.665 9.022   14.316  1.000 16.433  0 183 PHE A O   1 ? 
ATOM   1425 C CB  . PHE A 1 183 ? -10.539 9.233   15.768  1.000 18.899  0 183 PHE A CB  1 ? 
ATOM   1426 C CG  . PHE A 1 183 ? -10.082 9.017   14.348  1.000 17.399  0 183 PHE A CG  1 ? 
ATOM   1427 C CD1 . PHE A 1 183 ? -10.196 10.034  13.416  1.000 17.606  0 183 PHE A CD1 1 ? 
ATOM   1428 C CD2 . PHE A 1 183 ? -9.384  7.868   13.985  1.000 17.514  0 183 PHE A CD2 1 ? 
ATOM   1429 C CE1 . PHE A 1 183 ? -9.706  9.868   12.133  1.000 16.297  0 183 PHE A CE1 1 ? 
ATOM   1430 C CE2 . PHE A 1 183 ? -8.879  7.716   12.699  1.000 16.191  0 183 PHE A CE2 1 ? 
ATOM   1431 C CZ  . PHE A 1 183 ? -9.052  8.710   11.773  1.000 17.050  0 183 PHE A CZ  1 ? 
ATOM   1432 N N   . ARG A 1 184 ? -13.077 7.390   15.788  1.000 15.992  0 184 ARG A N   1 ? 
ATOM   1433 C CA  . ARG A 1 184 ? -13.947 6.360   15.155  1.000 17.602  0 184 ARG A CA  1 ? 
ATOM   1434 C C   . ARG A 1 184 ? -15.427 6.734   15.354  1.000 17.937  0 184 ARG A C   1 ? 
ATOM   1435 O O   . ARG A 1 184 ? -16.183 6.586   14.412  1.000 16.539  0 184 ARG A O   1 ? 
ATOM   1436 C CB  . ARG A 1 184 ? -13.642 4.966   15.695  1.000 18.666  0 184 ARG A CB  1 ? 
ATOM   1437 C CG  . ARG A 1 184 ? -12.296 4.434   15.234  1.000 18.982  0 184 ARG A CG  1 ? 
ATOM   1438 C CD  . ARG A 1 184 ? -12.095 2.993   15.627  1.000 19.501  0 184 ARG A CD  1 ? 
ATOM   1439 N NE  . ARG A 1 184 ? -12.270 2.755   17.055  1.000 19.679  0 184 ARG A NE  1 ? 
ATOM   1440 C CZ  . ARG A 1 184 ? -11.289 2.749   17.953  1.000 21.546  0 184 ARG A CZ  1 ? 
ATOM   1441 N NH1 . ARG A 1 184 ? -10.042 2.998   17.585  1.000 20.805  0 184 ARG A NH1 1 ? 
ATOM   1442 N NH2 . ARG A 1 184 ? -11.562 2.514   19.219  1.000 20.976  0 184 ARG A NH2 1 ? 
ATOM   1443 N N   . ARG A 1 185 ? -15.822 7.207   16.537  1.000 18.233  0 185 ARG A N   1 ? 
ATOM   1444 C CA  . ARG A 1 185 ? -17.225 7.655   16.755  1.000 19.040  0 185 ARG A CA  1 ? 
ATOM   1445 C C   . ARG A 1 185 ? -17.567 8.742   15.723  1.000 17.958  0 185 ARG A C   1 ? 
ATOM   1446 O O   . ARG A 1 185 ? -18.655 8.701   15.122  1.000 17.109  0 185 ARG A O   1 ? 
ATOM   1447 C CB  . ARG A 1 185 ? -17.417 8.224   18.165  1.000 20.635  0 185 ARG A CB  1 ? 
ATOM   1448 C CG  . ARG A 1 185 ? -17.390 7.188   19.280  1.000 18.664  0 185 ARG A CG  1 ? 
ATOM   1449 C CD  . ARG A 1 185 ? -18.114 7.699   20.524  1.000 19.118  0 185 ARG A CD  1 ? 
ATOM   1450 N NE  . ARG A 1 185 ? -17.479 8.892   21.087  1.000 18.736  0 185 ARG A NE  1 ? 
ATOM   1451 C CZ  . ARG A 1 185 ? -16.376 8.876   21.867  1.000 19.560  0 185 ARG A CZ  1 ? 
ATOM   1452 N NH1 . ARG A 1 185 ? -15.771 7.726   22.155  1.000 19.688  0 185 ARG A NH1 1 ? 
ATOM   1453 N NH2 . ARG A 1 185 ? -15.845 10.014  22.299  1.000 18.030  0 185 ARG A NH2 1 ? 
ATOM   1454 N N   . CYS A 1 186 ? -16.674 9.694   15.503  1.000 16.463  0 186 CYS A N   1 ? 
ATOM   1455 C CA  . CYS A 1 186 ? -16.958 10.828  14.586  1.000 16.244  0 186 CYS A CA  1 ? 
ATOM   1456 C C   . CYS A 1 186 ? -17.050 10.374  13.131  1.000 15.110  0 186 CYS A C   1 ? 
ATOM   1457 O O   . CYS A 1 186 ? -17.893 10.922  12.406  1.000 16.089  0 186 CYS A O   1 ? 
ATOM   1458 C CB  . CYS A 1 186 ? -15.958 11.953  14.775  1.000 16.905  0 186 CYS A CB  1 ? 
ATOM   1459 S SG  . CYS A 1 186 ? -16.269 12.795  16.336  1.000 19.794  0 186 CYS A SG  1 ? 
ATOM   1460 N N   . ILE A 1 187 ? -16.243 9.429   12.704  1.000 15.102  0 187 ILE A N   1 ? 
ATOM   1461 C CA  . ILE A 1 187 ? -16.393 8.807   11.362  1.000 16.022  0 187 ILE A CA  1 ? 
ATOM   1462 C C   . ILE A 1 187 ? -17.801 8.171   11.273  1.000 18.047  0 187 ILE A C   1 ? 
ATOM   1463 O O   . ILE A 1 187 ? -18.505 8.351   10.225  1.000 16.519  0 187 ILE A O   1 ? 
ATOM   1464 C CB  . ILE A 1 187 ? -15.266 7.795   11.112  1.000 15.795  0 187 ILE A CB  1 ? 
ATOM   1465 C CG1 . ILE A 1 187 ? -13.913 8.501   11.021  1.000 17.391  0 187 ILE A CG1 1 ? 
ATOM   1466 C CG2 . ILE A 1 187 ? -15.556 6.982   9.869   1.000 17.387  0 187 ILE A CG2 1 ? 
ATOM   1467 C CD1 . ILE A 1 187 ? -12.708 7.578   10.915  1.000 18.623  0 187 ILE A CD1 1 ? 
ATOM   1468 N N   . ARG A 1 188 ? -18.190 7.417   12.296  1.000 16.209  0 188 ARG A N   1 ? 
ATOM   1469 C CA  . ARG A 1 188 ? -19.520 6.739   12.313  1.000 18.293  0 188 ARG A CA  1 ? 
ATOM   1470 C C   . ARG A 1 188 ? -20.652 7.782   12.251  1.000 18.280  0 188 ARG A C   1 ? 
ATOM   1471 O O   . ARG A 1 188 ? -21.601 7.552   11.467  1.000 18.235  0 188 ARG A O   1 ? 
ATOM   1472 C CB  . ARG A 1 188 ? -19.668 5.831   13.529  1.000 18.392  0 188 ARG A CB  1 ? 
ATOM   1473 C CG  . ARG A 1 188 ? -18.781 4.612   13.480  1.000 18.892  0 188 ARG A CG  1 ? 
ATOM   1474 C CD  . ARG A 1 188 ? -19.254 3.640   14.526  1.000 20.711  0 188 ARG A CD  1 ? 
ATOM   1475 N NE  . ARG A 1 188 ? -18.528 2.415   14.518  1.000 21.056  0 188 ARG A NE  1 ? 
ATOM   1476 C CZ  . ARG A 1 188 ? -17.570 2.090   15.365  1.000 25.268  0 188 ARG A CZ  1 ? 
ATOM   1477 N NH1 . ARG A 1 188 ? -17.200 2.922   16.330  1.000 24.777  0 188 ARG A NH1 1 ? 
ATOM   1478 N NH2 . ARG A 1 188 ? -17.017 0.892   15.258  1.000 27.733  0 188 ARG A NH2 1 ? 
ATOM   1479 N N   . TYR A 1 189 ? -20.543 8.890   12.988  1.000 17.547  0 189 TYR A N   1 ? 
ATOM   1480 C CA  . TYR A 1 189 ? -21.565 9.960   12.994  1.000 18.053  0 189 TYR A CA  1 ? 
ATOM   1481 C C   . TYR A 1 189 ? -21.696 10.492  11.571  1.000 18.736  0 189 TYR A C   1 ? 
ATOM   1482 O O   . TYR A 1 189 ? -22.857 10.677  11.074  1.000 19.670  0 189 TYR A O   1 ? 
ATOM   1483 C CB  . TYR A 1 189 ? -21.253 11.113  13.956  1.000 17.326  0 189 TYR A CB  1 ? 
ATOM   1484 C CG  . TYR A 1 189 ? -21.106 10.761  15.420  1.000 18.345  0 189 TYR A CG  1 ? 
ATOM   1485 C CD1 . TYR A 1 189 ? -21.934 9.843   16.046  1.000 18.566  0 189 TYR A CD1 1 ? 
ATOM   1486 C CD2 . TYR A 1 189 ? -20.138 11.391  16.198  1.000 17.612  0 189 TYR A CD2 1 ? 
ATOM   1487 C CE1 . TYR A 1 189 ? -21.779 9.524   17.387  1.000 18.164  0 189 TYR A CE1 1 ? 
ATOM   1488 C CE2 . TYR A 1 189 ? -19.981 11.103  17.539  1.000 16.654  0 189 TYR A CE2 1 ? 
ATOM   1489 C CZ  . TYR A 1 189 ? -20.831 10.199  18.148  1.000 17.758  0 189 TYR A CZ  1 ? 
ATOM   1490 O OH  . TYR A 1 189 ? -20.661 9.930   19.469  1.000 17.185  0 189 TYR A OH  1 ? 
ATOM   1491 N N   . LEU A 1 190 ? -20.578 10.710  10.887  1.000 17.128  0 190 LEU A N   1 ? 
ATOM   1492 C CA  . LEU A 1 190 ? -20.621 11.279  9.515   1.000 20.020  0 190 LEU A CA  1 ? 
ATOM   1493 C C   . LEU A 1 190 ? -21.169 10.262  8.498   1.000 19.051  0 190 LEU A C   1 ? 
ATOM   1494 O O   . LEU A 1 190 ? -21.844 10.700  7.553   1.000 17.139  0 190 LEU A O   1 ? 
ATOM   1495 C CB  . LEU A 1 190 ? -19.248 11.787  9.119   1.000 23.306  0 190 LEU A CB  1 ? 
ATOM   1496 C CG  . LEU A 1 190 ? -18.863 13.078  9.842   1.000 27.820  0 190 LEU A CG  1 ? 
ATOM   1497 C CD1 . LEU A 1 190 ? -17.514 13.529  9.421   1.000 33.035  0 190 LEU A CD1 1 ? 
ATOM   1498 C CD2 . LEU A 1 190 ? -19.854 14.194  9.593   1.000 30.131  0 190 LEU A CD2 1 ? 
ATOM   1499 N N   . LYS A 1 191 ? -20.971 8.971   8.710   1.000 17.982  0 191 LYS A N   1 ? 
ATOM   1500 C CA  . LYS A 1 191 ? -21.583 7.934   7.862   1.000 18.890  0 191 LYS A CA  1 ? 
ATOM   1501 C C   . LYS A 1 191 ? -23.110 7.936   8.036   1.000 18.963  0 191 LYS A C   1 ? 
ATOM   1502 O O   . LYS A 1 191 ? -23.803 7.773   7.012   1.000 17.205  0 191 LYS A O   1 ? 
ATOM   1503 C CB  . LYS A 1 191 ? -20.950 6.592   8.160   1.000 21.512  0 191 LYS A CB  1 ? 
ATOM   1504 C CG  . LYS A 1 191 ? -19.526 6.483   7.624   1.000 22.814  0 191 LYS A CG  1 ? 
ATOM   1505 C CD  . LYS A 1 191 ? -18.879 5.193   7.927   1.000 25.994  0 191 LYS A CD  1 ? 
ATOM   1506 C CE  . LYS A 1 191 ? -17.595 5.005   7.147   1.000 27.565  0 191 LYS A CE  1 ? 
ATOM   1507 N NZ  . LYS A 1 191 ? -16.964 3.713   7.482   1.000 28.734  0 191 LYS A NZ  1 ? 
ATOM   1508 N N   . ARG A 1 192 ? -23.620 8.147   9.251   1.000 17.971  0 192 ARG A N   1 ? 
ATOM   1509 C CA  . ARG A 1 192 ? -25.090 8.130   9.467   1.000 18.277  0 192 ARG A CA  1 ? 
ATOM   1510 C C   . ARG A 1 192 ? -25.661 9.398   8.848   1.000 18.390  0 192 ARG A C   1 ? 
ATOM   1511 O O   . ARG A 1 192 ? -26.623 9.287   8.086   1.000 18.768  0 192 ARG A O   1 ? 
ATOM   1512 C CB  . ARG A 1 192 ? -25.499 7.994   10.931  1.000 16.005  0 192 ARG A CB  1 ? 
ATOM   1513 C CG  . ARG A 1 192 ? -27.013 8.101   11.146  1.000 16.996  0 192 ARG A CG  1 ? 
ATOM   1514 C CD  . ARG A 1 192 ? -27.855 7.232   10.228  1.000 18.381  0 192 ARG A CD  1 ? 
ATOM   1515 N NE  . ARG A 1 192 ? -27.646 5.816   10.473  1.000 18.820  0 192 ARG A NE  1 ? 
ATOM   1516 C CZ  . ARG A 1 192 ? -28.252 5.096   11.417  1.000 21.392  0 192 ARG A CZ  1 ? 
ATOM   1517 N NH1 . ARG A 1 192 ? -29.144 5.645   12.228  1.000 22.616  0 192 ARG A NH1 1 ? 
ATOM   1518 N NH2 . ARG A 1 192 ? -27.925 3.827   11.568  1.000 22.584  0 192 ARG A NH2 1 ? 
ATOM   1519 N N   . TRP A 1 193 ? -25.023 10.543  9.098   1.000 19.048  0 193 TRP A N   1 ? 
ATOM   1520 C CA  . TRP A 1 193 ? -25.336 11.826  8.411   1.000 18.343  0 193 TRP A CA  1 ? 
ATOM   1521 C C   . TRP A 1 193 ? -25.425 11.604  6.901   1.000 18.135  0 193 TRP A C   1 ? 
ATOM   1522 O O   . TRP A 1 193 ? -26.466 11.995  6.296   1.000 18.155  0 193 TRP A O   1 ? 
ATOM   1523 C CB  . TRP A 1 193 ? -24.349 12.899  8.764   1.000 17.088  0 193 TRP A CB  1 ? 
ATOM   1524 C CG  . TRP A 1 193 ? -24.449 14.113  7.907   1.000 16.661  0 193 TRP A CG  1 ? 
ATOM   1525 C CD1 . TRP A 1 193 ? -25.420 15.062  7.943   1.000 16.362  0 193 TRP A CD1 1 ? 
ATOM   1526 C CD2 . TRP A 1 193 ? -23.525 14.528  6.884   1.000 16.874  0 193 TRP A CD2 1 ? 
ATOM   1527 N NE1 . TRP A 1 193 ? -25.150 16.050  7.033   1.000 16.330  0 193 TRP A NE1 1 ? 
ATOM   1528 C CE2 . TRP A 1 193 ? -24.011 15.740  6.352   1.000 16.256  0 193 TRP A CE2 1 ? 
ATOM   1529 C CE3 . TRP A 1 193 ? -22.348 13.999  6.355   1.000 16.695  0 193 TRP A CE3 1 ? 
ATOM   1530 C CZ2 . TRP A 1 193 ? -23.340 16.450  5.367   1.000 15.644  0 193 TRP A CZ2 1 ? 
ATOM   1531 C CZ3 . TRP A 1 193 ? -21.698 14.688  5.343   1.000 17.428  0 193 TRP A CZ3 1 ? 
ATOM   1532 C CH2 . TRP A 1 193 ? -22.194 15.891  4.853   1.000 17.310  0 193 TRP A CH2 1 ? 
ATOM   1533 N N   . ARG A 1 194 ? -24.410 10.989  6.331   1.000 17.337  0 194 ARG A N   1 ? 
ATOM   1534 C CA  . ARG A 1 194 ? -24.322 10.717  4.880   1.000 19.336  0 194 ARG A CA  1 ? 
ATOM   1535 C C   . ARG A 1 194 ? -25.542 9.875   4.450   1.000 19.401  0 194 ARG A C   1 ? 
ATOM   1536 O O   . ARG A 1 194 ? -26.165 10.219  3.433   1.000 20.702  0 194 ARG A O   1 ? 
ATOM   1537 C CB  . ARG A 1 194 ? -23.023 9.988   4.541   1.000 21.701  0 194 ARG A CB  1 ? 
ATOM   1538 C CG  . ARG A 1 194 ? -22.831 9.707   3.059   1.000 27.853  0 194 ARG A CG  1 ? 
ATOM   1539 C CD  . ARG A 1 194 ? -23.088 8.309   2.532   1.000 31.864  0 194 ARG A CD  1 ? 
ATOM   1540 N NE  . ARG A 1 194 ? -23.027 7.260   3.516   1.000 36.896  0 194 ARG A NE  1 ? 
ATOM   1541 C CZ  . ARG A 1 194 ? -21.998 6.447   3.734   1.000 42.983  0 194 ARG A CZ  1 ? 
ATOM   1542 N NH1 . ARG A 1 194 ? -20.887 6.556   3.023   1.000 49.162  0 194 ARG A NH1 1 ? 
ATOM   1543 N NH2 . ARG A 1 194 ? -22.089 5.529   4.687   1.000 40.352  0 194 ARG A NH2 1 ? 
ATOM   1544 N N   . ASP A 1 195 ? -25.868 8.823   5.200   1.000 19.266  0 195 ASP A N   1 ? 
ATOM   1545 C CA  . ASP A 1 195 ? -26.976 7.899   4.871   1.000 21.834  0 195 ASP A CA  1 ? 
ATOM   1546 C C   . ASP A 1 195 ? -28.311 8.659   4.960   1.000 22.785  0 195 ASP A C   1 ? 
ATOM   1547 O O   . ASP A 1 195 ? -29.226 8.343   4.176   1.000 25.950  0 195 ASP A O   1 ? 
ATOM   1548 C CB  . ASP A 1 195 ? -26.937 6.660   5.774   1.000 22.805  0 195 ASP A CB  1 ? 
ATOM   1549 C CG  . ASP A 1 195 ? -25.843 5.656   5.413   1.000 24.514  0 195 ASP A CG  1 ? 
ATOM   1550 O OD1 . ASP A 1 195 ? -25.113 5.895   4.420   1.000 24.763  0 195 ASP A OD1 1 ? 
ATOM   1551 O OD2 . ASP A 1 195 ? -25.703 4.672   6.139   1.000 26.321  0 195 ASP A OD2 1 ? 
ATOM   1552 N N   . PHE A 1 196 ? -28.450 9.555   5.928   1.000 21.415  0 196 PHE A N   1 ? 
ATOM   1553 C CA  . PHE A 1 196 ? -29.697 10.296  6.189   1.000 22.437  0 196 PHE A CA  1 ? 
ATOM   1554 C C   . PHE A 1 196 ? -29.876 11.428  5.164   1.000 24.046  0 196 PHE A C   1 ? 
ATOM   1555 O O   . PHE A 1 196 ? -31.001 11.535  4.616   1.000 22.451  0 196 PHE A O   1 ? 
ATOM   1556 C CB  . PHE A 1 196 ? -29.747 10.795  7.627   1.000 22.207  0 196 PHE A CB  1 ? 
ATOM   1557 C CG  . PHE A 1 196 ? -31.040 11.482  7.973   1.000 22.952  0 196 PHE A CG  1 ? 
ATOM   1558 C CD1 . PHE A 1 196 ? -32.224 10.759  8.032   1.000 23.004  0 196 PHE A CD1 1 ? 
ATOM   1559 C CD2 . PHE A 1 196 ? -31.067 12.829  8.281   1.000 22.775  0 196 PHE A CD2 1 ? 
ATOM   1560 C CE1 . PHE A 1 196 ? -33.428 11.386  8.327   1.000 25.500  0 196 PHE A CE1 1 ? 
ATOM   1561 C CE2 . PHE A 1 196 ? -32.266 13.456  8.593   1.000 28.652  0 196 PHE A CE2 1 ? 
ATOM   1562 C CZ  . PHE A 1 196 ? -33.450 12.744  8.603   1.000 27.405  0 196 PHE A CZ  1 ? 
ATOM   1563 N N   . ARG A 1 197 ? -28.838 12.209  4.857   1.000 21.236  0 197 ARG A N   1 ? 
ATOM   1564 C CA  . ARG A 1 197 ? -29.019 13.478  4.087   1.000 21.942  0 197 ARG A CA  1 ? 
ATOM   1565 C C   . ARG A 1 197 ? -28.784 13.285  2.578   1.000 19.778  0 197 ARG A C   1 ? 
ATOM   1566 O O   . ARG A 1 197 ? -29.125 14.183  1.821   1.000 24.053  0 197 ARG A O   1 ? 
ATOM   1567 C CB  . ARG A 1 197 ? -28.136 14.605  4.626   1.000 21.856  0 197 ARG A CB  1 ? 
ATOM   1568 C CG  . ARG A 1 197 ? -28.575 15.168  5.967   1.000 22.298  0 197 ARG A CG  1 ? 
ATOM   1569 C CD  . ARG A 1 197 ? -30.031 15.632  6.008   1.000 24.464  0 197 ARG A CD  1 ? 
ATOM   1570 N NE  . ARG A 1 197 ? -30.502 16.251  4.766   1.000 24.216  0 197 ARG A NE  1 ? 
ATOM   1571 C CZ  . ARG A 1 197 ? -30.242 17.496  4.362   1.000 28.412  0 197 ARG A CZ  1 ? 
ATOM   1572 N NH1 . ARG A 1 197 ? -29.476 18.308  5.093   1.000 30.204  0 197 ARG A NH1 1 ? 
ATOM   1573 N NH2 . ARG A 1 197 ? -30.760 17.932  3.213   1.000 28.451  0 197 ARG A NH2 1 ? 
ATOM   1574 N N   . PHE A 1 198 ? -28.305 12.154  2.124   1.000 21.426  0 198 PHE A N   1 ? 
ATOM   1575 C CA  . PHE A 1 198 ? -27.998 11.929  0.691   1.000 25.425  0 198 PHE A CA  1 ? 
ATOM   1576 C C   . PHE A 1 198 ? -28.712 10.671  0.204   1.000 33.308  0 198 PHE A C   1 ? 
ATOM   1577 O O   . PHE A 1 198 ? -28.958 9.809   1.006   1.000 32.378  0 198 PHE A O   1 ? 
ATOM   1578 C CB  . PHE A 1 198 ? -26.490 11.809  0.479   1.000 21.963  0 198 PHE A CB  1 ? 
ATOM   1579 C CG  . PHE A 1 198 ? -25.679 13.016  0.894   1.000 20.839  0 198 PHE A CG  1 ? 
ATOM   1580 C CD1 . PHE A 1 198 ? -25.343 13.238  2.221   1.000 18.060  0 198 PHE A CD1 1 ? 
ATOM   1581 C CD2 . PHE A 1 198 ? -25.195 13.910  -0.060  1.000 19.606  0 198 PHE A CD2 1 ? 
ATOM   1582 C CE1 . PHE A 1 198 ? -24.560 14.329  2.582   1.000 17.207  0 198 PHE A CE1 1 ? 
ATOM   1583 C CE2 . PHE A 1 198 ? -24.433 15.006  0.319   1.000 18.955  0 198 PHE A CE2 1 ? 
ATOM   1584 C CZ  . PHE A 1 198 ? -24.103 15.201  1.634   1.000 17.340  0 198 PHE A CZ  1 ? 
ATOM   1585 N N   . SER A 1 199 ? -29.053 10.579  -1.085  1.000 52.212  0 199 SER A N   1 ? 
ATOM   1586 C CA  . SER A 1 199 ? -29.594 9.320   -1.666  1.000 55.082  0 199 SER A CA  1 ? 
ATOM   1587 C C   . SER A 1 199 ? -28.401 8.397   -1.939  1.000 63.066  0 199 SER A C   1 ? 
ATOM   1588 O O   . SER A 1 199 ? -27.328 8.917   -2.338  1.000 70.464  0 199 SER A O   1 ? 
ATOM   1589 C CB  . SER A 1 199 ? -30.442 9.564   -2.892  1.000 56.828  0 199 SER A CB  1 ? 
ATOM   1590 O OG  . SER A 1 199 ? -29.652 9.997   -3.987  1.000 50.379  0 199 SER A OG  1 ? 
ATOM   1591 N N   . SER A 1 200 ? -28.548 7.102   -1.638  1.000 66.753  0 200 SER A N   1 ? 
ATOM   1592 C CA  . SER A 1 200 ? -27.626 6.011   -2.062  1.000 69.158  0 200 SER A CA  1 ? 
ATOM   1593 C C   . SER A 1 200 ? -27.441 6.070   -3.581  1.000 63.583  0 200 SER A C   1 ? 
ATOM   1594 O O   . SER A 1 200 ? -26.414 5.582   -4.075  1.000 59.229  0 200 SER A O   1 ? 
ATOM   1595 C CB  . SER A 1 200 ? -28.142 4.661   -1.626  1.000 69.704  0 200 SER A CB  1 ? 
ATOM   1596 O OG  . SER A 1 200 ? -29.554 4.682   -1.452  1.000 70.954  0 200 SER A OG  1 ? 
ATOM   1597 N N   . ASP A 1 201 ? -28.422 6.658   -4.268  1.000 65.406  0 201 ASP A N   1 ? 
ATOM   1598 C CA  . ASP A 1 201 ? -28.454 6.861   -5.738  1.000 74.743  0 201 ASP A CA  1 ? 
ATOM   1599 C C   . ASP A 1 201 ? -27.232 7.665   -6.183  1.000 69.579  0 201 ASP A C   1 ? 
ATOM   1600 O O   . ASP A 1 201 ? -26.987 8.778   -5.622  1.000 71.960  0 201 ASP A O   1 ? 
ATOM   1601 C CB  . ASP A 1 201 ? -29.747 7.553   -6.191  1.000 78.481  0 201 ASP A CB  1 ? 
ATOM   1602 C CG  . ASP A 1 201 ? -30.758 6.603   -6.813  1.000 83.768  0 201 ASP A CG  1 ? 
ATOM   1603 O OD1 . ASP A 1 201 ? -31.346 6.973   -7.860  1.000 77.095  0 201 ASP A OD1 1 ? 
ATOM   1604 O OD2 . ASP A 1 201 ? -30.937 5.490   -6.261  1.000 91.814  0 201 ASP A OD2 1 ? 
ATOM   1605 N N   . GLY A 1 202 ? -26.533 7.125   -7.186  1.000 64.341  0 202 GLY A N   1 ? 
ATOM   1606 C CA  . GLY A 1 202 ? -25.470 7.806   -7.942  1.000 58.494  0 202 GLY A CA  1 ? 
ATOM   1607 C C   . GLY A 1 202 ? -24.283 8.118   -7.057  1.000 51.744  0 202 GLY A C   1 ? 
ATOM   1608 O O   . GLY A 1 202 ? -24.098 7.433   -6.021  1.000 41.849  0 202 GLY A O   1 ? 
ATOM   1609 N N   . ASN A 1 203 ? -23.512 9.124   -7.454  1.000 48.746  0 203 ASN A N   1 ? 
ATOM   1610 C CA  . ASN A 1 203 ? -22.258 9.532   -6.778  1.000 50.428  0 203 ASN A CA  1 ? 
ATOM   1611 C C   . ASN A 1 203 ? -22.539 10.689  -5.816  1.000 46.414  0 203 ASN A C   1 ? 
ATOM   1612 O O   . ASN A 1 203 ? -21.542 11.213  -5.264  1.000 44.097  0 203 ASN A O   1 ? 
ATOM   1613 C CB  . ASN A 1 203 ? -21.185 9.948   -7.788  1.000 51.993  0 203 ASN A CB  1 ? 
ATOM   1614 C CG  . ASN A 1 203 ? -20.858 8.855   -8.782  1.000 58.203  0 203 ASN A CG  1 ? 
ATOM   1615 O OD1 . ASN A 1 203 ? -20.437 7.758   -8.399  1.000 50.959  0 203 ASN A OD1 1 ? 
ATOM   1616 N ND2 . ASN A 1 203 ? -21.059 9.141   -10.058 1.000 56.277  0 203 ASN A ND2 1 ? 
ATOM   1617 N N   . ALA A 1 204 ? -23.818 11.101  -5.668  1.000 42.877  0 204 ALA A N   1 ? 
ATOM   1618 C CA  . ALA A 1 204 ? -24.230 12.300  -4.889  1.000 40.765  0 204 ALA A CA  1 ? 
ATOM   1619 C C   . ALA A 1 204 ? -23.734 12.146  -3.453  1.000 35.210  0 204 ALA A C   1 ? 
ATOM   1620 O O   . ALA A 1 204 ? -23.257 13.141  -2.911  1.000 39.850  0 204 ALA A O   1 ? 
ATOM   1621 C CB  . ALA A 1 204 ? -25.740 12.517  -4.932  1.000 42.275  0 204 ALA A CB  1 ? 
ATOM   1622 N N   . ALA A 1 205 ? -23.820 10.929  -2.882  1.000 34.964  0 205 ALA A N   1 ? 
ATOM   1623 C CA  . ALA A 1 205 ? -23.392 10.611  -1.495  1.000 33.743  0 205 ALA A CA  1 ? 
ATOM   1624 C C   . ALA A 1 205 ? -21.864 10.568  -1.450  1.000 30.206  0 205 ALA A C   1 ? 
ATOM   1625 O O   . ALA A 1 205 ? -21.249 9.763   -2.154  1.000 31.254  0 205 ALA A O   1 ? 
ATOM   1626 C CB  . ALA A 1 205 ? -23.999 9.301   -1.047  1.000 33.335  0 205 ALA A CB  1 ? 
ATOM   1627 N N   . PRO A 1 206 ? -21.199 11.388  -0.610  1.000 28.659  0 206 PRO A N   1 ? 
ATOM   1628 C CA  . PRO A 1 206 ? -19.775 11.190  -0.367  1.000 28.138  0 206 PRO A CA  1 ? 
ATOM   1629 C C   . PRO A 1 206 ? -19.538 9.733   0.066   1.000 29.808  0 206 PRO A C   1 ? 
ATOM   1630 O O   . PRO A 1 206 ? -20.317 9.226   0.890   1.000 29.409  0 206 PRO A O   1 ? 
ATOM   1631 C CB  . PRO A 1 206 ? -19.429 12.162  0.761   1.000 27.129  0 206 PRO A CB  1 ? 
ATOM   1632 C CG  . PRO A 1 206 ? -20.764 12.522  1.381   1.000 27.810  0 206 PRO A CG  1 ? 
ATOM   1633 C CD  . PRO A 1 206 ? -21.766 12.434  0.259   1.000 28.469  0 206 PRO A CD  1 ? 
ATOM   1634 N N   . LEU A 1 207 ? -18.506 9.096   -0.493  1.000 26.304  0 207 LEU A N   1 ? 
ATOM   1635 C CA  . LEU A 1 207 ? -18.107 7.724   -0.117  1.000 27.081  0 207 LEU A CA  1 ? 
ATOM   1636 C C   . LEU A 1 207 ? -17.595 7.716   1.325   1.000 22.974  0 207 LEU A C   1 ? 
ATOM   1637 O O   . LEU A 1 207 ? -16.955 8.719   1.776   1.000 22.960  0 207 LEU A O   1 ? 
ATOM   1638 C CB  . LEU A 1 207 ? -17.066 7.221   -1.127  1.000 30.489  0 207 LEU A CB  1 ? 
ATOM   1639 C CG  . LEU A 1 207 ? -17.601 7.041   -2.545  1.000 35.077  0 207 LEU A CG  1 ? 
ATOM   1640 C CD1 . LEU A 1 207 ? -16.476 6.662   -3.502  1.000 37.761  0 207 LEU A CD1 1 ? 
ATOM   1641 C CD2 . LEU A 1 207 ? -18.706 6.000   -2.589  1.000 36.576  0 207 LEU A CD2 1 ? 
ATOM   1642 N N   . GLY A 1 208 ? -17.952 6.654   2.048   1.000 20.347  0 208 GLY A N   1 ? 
ATOM   1643 C CA  . GLY A 1 208 ? -17.380 6.290   3.340   1.000 19.071  0 208 GLY A CA  1 ? 
ATOM   1644 C C   . GLY A 1 208 ? -15.873 6.449   3.346   1.000 20.117  0 208 GLY A C   1 ? 
ATOM   1645 O O   . GLY A 1 208 ? -15.343 7.050   4.285   1.000 17.794  0 208 GLY A O   1 ? 
ATOM   1646 N N   . ILE A 1 209 ? -15.190 5.944   2.327   1.000 22.100  0 209 ILE A N   1 ? 
ATOM   1647 C CA  . ILE A 1 209 ? -13.703 6.004   2.317   1.000 24.270  0 209 ILE A CA  1 ? 
ATOM   1648 C C   . ILE A 1 209 ? -13.285 7.467   2.200   1.000 20.507  0 209 ILE A C   1 ? 
ATOM   1649 O O   . ILE A 1 209 ? -12.295 7.845   2.849   1.000 20.085  0 209 ILE A O   1 ? 
ATOM   1650 C CB  . ILE A 1 209 ? -13.070 5.103   1.240   1.000 25.672  0 209 ILE A CB  1 ? 
ATOM   1651 C CG1 . ILE A 1 209 ? -11.558 4.993   1.452   1.000 28.440  0 209 ILE A CG1 1 ? 
ATOM   1652 C CG2 . ILE A 1 209 ? -13.399 5.610   -0.153  1.000 24.128  0 209 ILE A CG2 1 ? 
ATOM   1653 C CD1 . ILE A 1 209 ? -10.918 3.825   0.717   1.000 32.495  0 209 ILE A CD1 1 ? 
ATOM   1654 N N   . GLY A 1 210 ? -14.065 8.293   1.510   1.000 21.018  0 210 GLY A N   1 ? 
ATOM   1655 C CA  . GLY A 1 210 ? -13.782 9.733   1.381   1.000 19.805  0 210 GLY A CA  1 ? 
ATOM   1656 C C   . GLY A 1 210 ? -13.884 10.475  2.704   1.000 19.479  0 210 GLY A C   1 ? 
ATOM   1657 O O   . GLY A 1 210 ? -13.002 11.347  3.013   1.000 17.350  0 210 GLY A O   1 ? 
ATOM   1658 N N   . LEU A 1 211 ? -14.964 10.245  3.429   1.000 18.074  0 211 LEU A N   1 ? 
ATOM   1659 C CA  . LEU A 1 211 ? -15.165 10.836  4.761   1.000 17.777  0 211 LEU A CA  1 ? 
ATOM   1660 C C   . LEU A 1 211 ? -14.049 10.367  5.685   1.000 16.431  0 211 LEU A C   1 ? 
ATOM   1661 O O   . LEU A 1 211 ? -13.643 11.158  6.543   1.000 17.694  0 211 LEU A O   1 ? 
ATOM   1662 C CB  . LEU A 1 211 ? -16.538 10.439  5.320   1.000 18.568  0 211 LEU A CB  1 ? 
ATOM   1663 C CG  . LEU A 1 211 ? -17.734 10.986  4.537   1.000 19.542  0 211 LEU A CG  1 ? 
ATOM   1664 C CD1 . LEU A 1 211 ? -19.037 10.399  5.091   1.000 20.248  0 211 LEU A CD1 1 ? 
ATOM   1665 C CD2 . LEU A 1 211 ? -17.775 12.500  4.557   1.000 21.597  0 211 LEU A CD2 1 ? 
ATOM   1666 N N   . THR A 1 212 ? -13.626 9.122   5.557   1.000 15.618  0 212 THR A N   1 ? 
ATOM   1667 C CA  . THR A 1 212 ? -12.576 8.521   6.429   1.000 17.051  0 212 THR A CA  1 ? 
ATOM   1668 C C   . THR A 1 212 ? -11.246 9.162   6.082   1.000 16.350  0 212 THR A C   1 ? 
ATOM   1669 O O   . THR A 1 212 ? -10.531 9.581   7.030   1.000 18.480  0 212 THR A O   1 ? 
ATOM   1670 C CB  . THR A 1 212 ? -12.544 7.002   6.304   1.000 17.725  0 212 THR A CB  1 ? 
ATOM   1671 O OG1 . THR A 1 212 ? -13.841 6.527   6.649   1.000 17.997  0 212 THR A OG1 1 ? 
ATOM   1672 C CG2 . THR A 1 212 ? -11.509 6.328   7.172   1.000 18.308  0 212 THR A CG2 1 ? 
ATOM   1673 N N   . ALA A 1 213 ? -10.979 9.346   4.797   1.000 18.082  0 213 ALA A N   1 ? 
ATOM   1674 C CA  . ALA A 1 213 ? -9.732  10.010  4.330   1.000 18.270  0 213 ALA A CA  1 ? 
ATOM   1675 C C   . ALA A 1 213 ? -9.739  11.455  4.853   1.000 18.244  0 213 ALA A C   1 ? 
ATOM   1676 O O   . ALA A 1 213 ? -8.707  11.910  5.407   1.000 16.656  0 213 ALA A O   1 ? 
ATOM   1677 C CB  . ALA A 1 213 ? -9.622  9.948   2.828   1.000 18.881  0 213 ALA A CB  1 ? 
ATOM   1678 N N   . ALA A 1 214 ? -10.882 12.153  4.745   1.000 17.194  0 214 ALA A N   1 ? 
ATOM   1679 C CA  . ALA A 1 214 ? -11.018 13.543  5.250   1.000 15.885  0 214 ALA A CA  1 ? 
ATOM   1680 C C   . ALA A 1 214 ? -10.699 13.573  6.738   1.000 16.648  0 214 ALA A C   1 ? 
ATOM   1681 O O   . ALA A 1 214 ? -9.986  14.496  7.172   1.000 17.252  0 214 ALA A O   1 ? 
ATOM   1682 C CB  . ALA A 1 214 ? -12.394 14.118  4.939   1.000 15.700  0 214 ALA A CB  1 ? 
ATOM   1683 N N   . ALA A 1 215 ? -11.242 12.629  7.518   1.000 17.611  0 215 ALA A N   1 ? 
ATOM   1684 C CA  . ALA A 1 215 ? -11.019 12.561  8.975   1.000 17.674  0 215 ALA A CA  1 ? 
ATOM   1685 C C   . ALA A 1 215 ? -9.525  12.303  9.242   1.000 17.219  0 215 ALA A C   1 ? 
ATOM   1686 O O   . ALA A 1 215 ? -8.952  12.882  10.168  1.000 15.015  0 215 ALA A O   1 ? 
ATOM   1687 C CB  . ALA A 1 215 ? -11.880 11.487  9.568   1.000 19.152  0 215 ALA A CB  1 ? 
ATOM   1688 N N   . TYR A 1 216 ? -8.898  11.458  8.448   1.000 16.113  0 216 TYR A N   1 ? 
ATOM   1689 C CA  . TYR A 1 216 ? -7.445  11.220  8.595   1.000 16.564  0 216 TYR A CA  1 ? 
ATOM   1690 C C   . TYR A 1 216 ? -6.696  12.550  8.510   1.000 16.730  0 216 TYR A C   1 ? 
ATOM   1691 O O   . TYR A 1 216 ? -5.791  12.854  9.346   1.000 15.358  0 216 TYR A O   1 ? 
ATOM   1692 C CB  . TYR A 1 216 ? -6.923  10.243  7.553   1.000 15.098  0 216 TYR A CB  1 ? 
ATOM   1693 C CG  . TYR A 1 216 ? -5.428  10.092  7.638   1.000 16.800  0 216 TYR A CG  1 ? 
ATOM   1694 C CD1 . TYR A 1 216 ? -4.852  9.337   8.654   1.000 17.072  0 216 TYR A CD1 1 ? 
ATOM   1695 C CD2 . TYR A 1 216 ? -4.585  10.770  6.770   1.000 16.530  0 216 TYR A CD2 1 ? 
ATOM   1696 C CE1 . TYR A 1 216 ? -3.480  9.195   8.758   1.000 19.590  0 216 TYR A CE1 1 ? 
ATOM   1697 C CE2 . TYR A 1 216 ? -3.212  10.687  6.906   1.000 19.332  0 216 TYR A CE2 1 ? 
ATOM   1698 C CZ  . TYR A 1 216 ? -2.660  9.847   7.862   1.000 20.164  0 216 TYR A CZ  1 ? 
ATOM   1699 O OH  . TYR A 1 216 ? -1.313  9.733   7.992   1.000 22.153  0 216 TYR A OH  1 ? 
ATOM   1700 N N   . TRP A 1 217 ? -7.036  13.367  7.514   1.000 16.344  0 217 TRP A N   1 ? 
ATOM   1701 C CA  . TRP A 1 217 ? -6.271  14.620  7.286   1.000 16.493  0 217 TRP A CA  1 ? 
ATOM   1702 C C   . TRP A 1 217 ? -6.583  15.601  8.415   1.000 17.154  0 217 TRP A C   1 ? 
ATOM   1703 O O   . TRP A 1 217 ? -5.680  16.293  8.815   1.000 16.976  0 217 TRP A O   1 ? 
ATOM   1704 C CB  . TRP A 1 217 ? -6.550  15.196  5.897   1.000 16.270  0 217 TRP A CB  1 ? 
ATOM   1705 C CG  . TRP A 1 217 ? -6.007  14.354  4.787   1.000 15.570  0 217 TRP A CG  1 ? 
ATOM   1706 C CD1 . TRP A 1 217 ? -6.723  13.781  3.788   1.000 15.440  0 217 TRP A CD1 1 ? 
ATOM   1707 C CD2 . TRP A 1 217 ? -4.629  14.110  4.485   1.000 15.809  0 217 TRP A CD2 1 ? 
ATOM   1708 N NE1 . TRP A 1 217 ? -5.891  13.141  2.925   1.000 17.494  0 217 TRP A NE1 1 ? 
ATOM   1709 C CE2 . TRP A 1 217 ? -4.594  13.331  3.329   1.000 15.221  0 217 TRP A CE2 1 ? 
ATOM   1710 C CE3 . TRP A 1 217 ? -3.424  14.450  5.099   1.000 16.976  0 217 TRP A CE3 1 ? 
ATOM   1711 C CZ2 . TRP A 1 217 ? -3.407  12.883  2.759   1.000 16.133  0 217 TRP A CZ2 1 ? 
ATOM   1712 C CZ3 . TRP A 1 217 ? -2.250  13.949  4.580   1.000 17.604  0 217 TRP A CZ3 1 ? 
ATOM   1713 C CH2 . TRP A 1 217 ? -2.239  13.195  3.409   1.000 16.356  0 217 TRP A CH2 1 ? 
ATOM   1714 N N   . TRP A 1 218 ? -7.847  15.702  8.847   1.000 14.999  0 218 TRP A N   1 ? 
ATOM   1715 C CA  . TRP A 1 218 ? -8.326  16.923  9.514   1.000 16.689  0 218 TRP A CA  1 ? 
ATOM   1716 C C   . TRP A 1 218 ? -8.947  16.678  10.884  1.000 17.777  0 218 TRP A C   1 ? 
ATOM   1717 O O   . TRP A 1 218 ? -9.173  17.685  11.576  1.000 19.311  0 218 TRP A O   1 ? 
ATOM   1718 C CB  . TRP A 1 218 ? -9.300  17.659  8.608   1.000 17.385  0 218 TRP A CB  1 ? 
ATOM   1719 C CG  . TRP A 1 218 ? -8.637  18.106  7.347   1.000 18.151  0 218 TRP A CG  1 ? 
ATOM   1720 C CD1 . TRP A 1 218 ? -7.426  18.729  7.219   1.000 18.231  0 218 TRP A CD1 1 ? 
ATOM   1721 C CD2 . TRP A 1 218 ? -9.143  17.948  6.018   1.000 18.068  0 218 TRP A CD2 1 ? 
ATOM   1722 N NE1 . TRP A 1 218 ? -7.166  18.986  5.899   1.000 18.307  0 218 TRP A NE1 1 ? 
ATOM   1723 C CE2 . TRP A 1 218 ? -8.203  18.529  5.135   1.000 17.369  0 218 TRP A CE2 1 ? 
ATOM   1724 C CE3 . TRP A 1 218 ? -10.335 17.447  5.497   1.000 18.693  0 218 TRP A CE3 1 ? 
ATOM   1725 C CZ2 . TRP A 1 218 ? -8.410  18.592  3.761   1.000 18.125  0 218 TRP A CZ2 1 ? 
ATOM   1726 C CZ3 . TRP A 1 218 ? -10.522 17.471  4.130   1.000 18.153  0 218 TRP A CZ3 1 ? 
ATOM   1727 C CH2 . TRP A 1 218 ? -9.594  18.075  3.275   1.000 16.836  0 218 TRP A CH2 1 ? 
ATOM   1728 N N   . PHE A 1 219 ? -9.219  15.447  11.297  1.000 19.467  0 219 PHE A N   1 ? 
ATOM   1729 C CA  . PHE A 1 219 ? -9.909  15.270  12.608  1.000 19.196  0 219 PHE A CA  1 ? 
ATOM   1730 C C   . PHE A 1 219 ? -8.968  15.702  13.723  1.000 20.539  0 219 PHE A C   1 ? 
ATOM   1731 O O   . PHE A 1 219 ? -7.733  15.363  13.675  1.000 17.403  0 219 PHE A O   1 ? 
ATOM   1732 C CB  . PHE A 1 219 ? -10.371 13.853  12.840  1.000 17.244  0 219 PHE A CB  1 ? 
ATOM   1733 C CG  . PHE A 1 219 ? -10.861 13.611  14.230  1.000 17.308  0 219 PHE A CG  1 ? 
ATOM   1734 C CD1 . PHE A 1 219 ? -12.177 13.841  14.568  1.000 16.454  0 219 PHE A CD1 1 ? 
ATOM   1735 C CD2 . PHE A 1 219 ? -9.976  13.189  15.216  1.000 17.181  0 219 PHE A CD2 1 ? 
ATOM   1736 C CE1 . PHE A 1 219 ? -12.608 13.615  15.860  1.000 16.448  0 219 PHE A CE1 1 ? 
ATOM   1737 C CE2 . PHE A 1 219 ? -10.410 12.983  16.506  1.000 16.270  0 219 PHE A CE2 1 ? 
ATOM   1738 C CZ  . PHE A 1 219 ? -11.726 13.193  16.818  1.000 16.165  0 219 PHE A CZ  1 ? 
ATOM   1739 N N   . GLN A 1 220 ? -9.533  16.390  14.716  1.000 19.594  0 220 GLN A N   1 ? 
ATOM   1740 C CA  . GLN A 1 220 ? -8.793  16.822  15.914  1.000 21.218  0 220 GLN A CA  1 ? 
ATOM   1741 C C   . GLN A 1 220 ? -9.593  16.373  17.109  1.000 19.310  0 220 GLN A C   1 ? 
ATOM   1742 O O   . GLN A 1 220 ? -10.777 16.640  17.148  1.000 16.976  0 220 GLN A O   1 ? 
ATOM   1743 C CB  . GLN A 1 220 ? -8.581  18.338  15.973  1.000 22.940  0 220 GLN A CB  1 ? 
ATOM   1744 C CG  . GLN A 1 220 ? -7.731  18.892  14.845  1.000 29.590  0 220 GLN A CG  1 ? 
ATOM   1745 C CD  . GLN A 1 220 ? -6.318  18.364  14.907  1.000 37.571  0 220 GLN A CD  1 ? 
ATOM   1746 O OE1 . GLN A 1 220 ? -5.810  18.035  15.965  1.000 43.504  0 220 GLN A OE1 1 ? 
ATOM   1747 N NE2 . GLN A 1 220 ? -5.691  18.222  13.758  1.000 40.297  0 220 GLN A NE2 1 ? 
ATOM   1748 N N   . VAL A 1 221 ? -8.932  15.733  18.059  1.000 19.518  0 221 VAL A N   1 ? 
ATOM   1749 C CA  . VAL A 1 221 ? -9.574  15.331  19.336  1.000 21.584  0 221 VAL A CA  1 ? 
ATOM   1750 C C   . VAL A 1 221 ? -10.155 16.589  19.980  1.000 20.446  0 221 VAL A C   1 ? 
ATOM   1751 O O   . VAL A 1 221 ? -9.470  17.629  19.998  1.000 20.054  0 221 VAL A O   1 ? 
ATOM   1752 C CB  . VAL A 1 221 ? -8.550  14.638  20.248  1.000 23.465  0 221 VAL A CB  1 ? 
ATOM   1753 C CG1 . VAL A 1 221 ? -9.026  14.576  21.684  1.000 24.378  0 221 VAL A CG1 1 ? 
ATOM   1754 C CG2 . VAL A 1 221 ? -8.216  13.266  19.710  1.000 25.276  0 221 VAL A CG2 1 ? 
ATOM   1755 N N   . SER A 1 222 ? -11.313 16.484  20.609  1.000 19.947  0 222 SER A N   1 ? 
ATOM   1756 C CA  . SER A 1 222 ? -11.833 17.561  21.492  1.000 19.580  0 222 SER A CA  1 ? 
ATOM   1757 C C   . SER A 1 222 ? -12.213 16.963  22.857  1.000 19.727  0 222 SER A C   1 ? 
ATOM   1758 O O   . SER A 1 222 ? -13.148 16.082  22.915  1.000 18.452  0 222 SER A O   1 ? 
ATOM   1759 C CB  . SER A 1 222 ? -12.968 18.292  20.877  1.000 18.945  0 222 SER A CB  1 ? 
ATOM   1760 O OG  . SER A 1 222 ? -13.406 19.335  21.756  1.000 21.474  0 222 SER A OG  1 ? 
ATOM   1761 N N   . LYS A 1 223 ? -11.510 17.351  23.919  1.000 21.136  0 223 LYS A N   1 ? 
ATOM   1762 C CA  . LYS A 1 223 ? -11.799 16.799  25.273  1.000 26.583  0 223 LYS A CA  1 ? 
ATOM   1763 C C   . LYS A 1 223 ? -11.530 17.867  26.340  1.000 30.063  0 223 LYS A C   1 ? 
ATOM   1764 O O   . LYS A 1 223 ? -10.853 18.832  26.058  1.000 26.875  0 223 LYS A O   1 ? 
ATOM   1765 C CB  . LYS A 1 223 ? -11.026 15.495  25.493  1.000 24.444  0 223 LYS A CB  1 ? 
ATOM   1766 C CG  . LYS A 1 223 ? -9.512  15.623  25.418  1.000 25.712  0 223 LYS A CG  1 ? 
ATOM   1767 C CD  . LYS A 1 223 ? -8.796  14.328  25.686  1.000 26.919  0 223 LYS A CD  1 ? 
ATOM   1768 C CE  . LYS A 1 223 ? -7.290  14.395  25.503  1.000 27.431  0 223 LYS A CE  1 ? 
ATOM   1769 N NZ  . LYS A 1 223 ? -6.713  13.039  25.424  1.000 26.829  0 223 LYS A NZ  1 ? 
ATOM   1770 N N   . GLY A 1 224 ? -12.281 17.811  27.422  1.000 41.512  0 224 GLY A N   1 ? 
ATOM   1771 C CA  . GLY A 1 224 ? -12.115 18.706  28.583  1.000 43.893  0 224 GLY A CA  1 ? 
ATOM   1772 C C   . GLY A 1 224 ? -12.507 17.978  29.848  1.000 41.505  0 224 GLY A C   1 ? 
ATOM   1773 O O   . GLY A 1 224 ? -11.742 17.086  30.282  1.000 38.628  0 224 GLY A O   1 ? 
ATOM   1774 N N   . SER A 1 225 ? -13.694 18.297  30.361  1.000 41.705  0 225 SER A N   1 ? 
ATOM   1775 C CA  . SER A 1 225 ? -14.364 17.624  31.506  1.000 42.984  0 225 SER A CA  1 ? 
ATOM   1776 C C   . SER A 1 225 ? -14.786 16.208  31.051  1.000 37.695  0 225 SER A C   1 ? 
ATOM   1777 O O   . SER A 1 225 ? -14.808 15.283  31.879  1.000 31.415  0 225 SER A O   1 ? 
ATOM   1778 C CB  . SER A 1 225 ? -15.529 18.486  32.008  1.000 42.653  0 225 SER A CB  1 ? 
ATOM   1779 O OG  . SER A 1 225 ? -15.077 19.816  32.320  1.000 51.854  0 225 SER A OG  1 ? 
ATOM   1780 N N   . GLY A 1 226 ? -14.969 16.040  29.733  1.000 32.999  0 226 GLY A N   1 ? 
ATOM   1781 C CA  . GLY A 1 226 ? -15.040 14.742  29.039  1.000 31.688  0 226 GLY A CA  1 ? 
ATOM   1782 C C   . GLY A 1 226 ? -14.698 14.895  27.560  1.000 29.956  0 226 GLY A C   1 ? 
ATOM   1783 O O   . GLY A 1 226 ? -14.300 15.991  27.124  1.000 23.776  0 226 GLY A O   1 ? 
ATOM   1784 N N   . TYR A 1 227 ? -14.871 13.834  26.793  1.000 24.750  0 227 TYR A N   1 ? 
ATOM   1785 C CA  . TYR A 1 227 ? -14.821 13.941  25.331  1.000 23.369  0 227 TYR A CA  1 ? 
ATOM   1786 C C   . TYR A 1 227 ? -16.003 14.817  24.925  1.000 21.819  0 227 TYR A C   1 ? 
ATOM   1787 O O   . TYR A 1 227 ? -17.066 14.775  25.575  1.000 20.285  0 227 TYR A O   1 ? 
ATOM   1788 C CB  . TYR A 1 227 ? -14.700 12.545  24.730  1.000 22.773  0 227 TYR A CB  1 ? 
ATOM   1789 C CG  . TYR A 1 227 ? -13.292 12.018  24.818  1.000 22.129  0 227 TYR A CG  1 ? 
ATOM   1790 C CD1 . TYR A 1 227 ? -12.812 11.391  25.968  1.000 22.284  0 227 TYR A CD1 1 ? 
ATOM   1791 C CD2 . TYR A 1 227 ? -12.389 12.273  23.802  1.000 22.683  0 227 TYR A CD2 1 ? 
ATOM   1792 C CE1 . TYR A 1 227 ? -11.496 10.960  26.050  1.000 21.957  0 227 TYR A CE1 1 ? 
ATOM   1793 C CE2 . TYR A 1 227 ? -11.079 11.827  23.866  1.000 20.848  0 227 TYR A CE2 1 ? 
ATOM   1794 C CZ  . TYR A 1 227 ? -10.620 11.200  25.006  1.000 21.004  0 227 TYR A CZ  1 ? 
ATOM   1795 O OH  . TYR A 1 227 ? -9.313  10.791  25.030  1.000 20.992  0 227 TYR A OH  1 ? 
ATOM   1796 N N   . ASP A 1 228 ? -15.768 15.684  23.945  1.000 21.992  0 228 ASP A N   1 ? 
ATOM   1797 C CA  . ASP A 1 228 ? -16.781 16.608  23.403  1.000 20.117  0 228 ASP A CA  1 ? 
ATOM   1798 C C   . ASP A 1 228 ? -16.946 16.305  21.901  1.000 19.861  0 228 ASP A C   1 ? 
ATOM   1799 O O   . ASP A 1 228 ? -16.265 16.946  21.059  1.000 18.640  0 228 ASP A O   1 ? 
ATOM   1800 C CB  . ASP A 1 228 ? -16.370 18.030  23.759  1.000 20.445  0 228 ASP A CB  1 ? 
ATOM   1801 C CG  . ASP A 1 228 ? -17.423 19.069  23.452  1.000 21.747  0 228 ASP A CG  1 ? 
ATOM   1802 O OD1 . ASP A 1 228 ? -18.388 18.760  22.708  1.000 19.920  0 228 ASP A OD1 1 ? 
ATOM   1803 O OD2 . ASP A 1 228 ? -17.242 20.181  23.926  1.000 24.161  0 228 ASP A OD2 1 ? 
ATOM   1804 N N   . ASP A 1 229 ? -17.799 15.337  21.576  1.000 18.874  0 229 ASP A N   1 ? 
ATOM   1805 C CA  . ASP A 1 229 ? -17.973 14.851  20.192  1.000 17.874  0 229 ASP A CA  1 ? 
ATOM   1806 C C   . ASP A 1 229 ? -18.587 15.972  19.350  1.000 18.382  0 229 ASP A C   1 ? 
ATOM   1807 O O   . ASP A 1 229 ? -18.202 16.104  18.196  1.000 16.179  0 229 ASP A O   1 ? 
ATOM   1808 C CB  . ASP A 1 229 ? -18.819 13.597  20.177  1.000 18.622  0 229 ASP A CB  1 ? 
ATOM   1809 C CG  . ASP A 1 229 ? -18.145 12.399  20.794  1.000 19.878  0 229 ASP A CG  1 ? 
ATOM   1810 O OD1 . ASP A 1 229 ? -17.030 12.561  21.354  1.000 18.553  0 229 ASP A OD1 1 ? 
ATOM   1811 O OD2 . ASP A 1 229 ? -18.763 11.329  20.742  1.000 21.284  0 229 ASP A OD2 1 ? 
ATOM   1812 N N   . ARG A 1 230 ? -19.441 16.809  19.947  1.000 18.281  0 230 ARG A N   1 ? 
ATOM   1813 C CA  . ARG A 1 230 ? -20.115 17.918  19.227  1.000 18.288  0 230 ARG A CA  1 ? 
ATOM   1814 C C   . ARG A 1 230 ? -19.057 18.915  18.750  1.000 19.357  0 230 ARG A C   1 ? 
ATOM   1815 O O   . ARG A 1 230 ? -19.122 19.339  17.564  1.000 17.644  0 230 ARG A O   1 ? 
ATOM   1816 C CB  . ARG A 1 230 ? -21.159 18.627  20.100  1.000 18.965  0 230 ARG A CB  1 ? 
ATOM   1817 C CG  . ARG A 1 230 ? -22.011 19.645  19.342  1.000 20.093  0 230 ARG A CG  1 ? 
ATOM   1818 C CD  . ARG A 1 230 ? -22.466 20.834  20.191  1.000 20.535  0 230 ARG A CD  1 ? 
ATOM   1819 N NE  . ARG A 1 230 ? -21.290 21.511  20.713  1.000 20.812  0 230 ARG A NE  1 ? 
ATOM   1820 C CZ  . ARG A 1 230 ? -20.455 22.284  20.023  1.000 20.475  0 230 ARG A CZ  1 ? 
ATOM   1821 N NH1 . ARG A 1 230 ? -20.678 22.595  18.759  1.000 19.567  0 230 ARG A NH1 1 ? 
ATOM   1822 N NH2 . ARG A 1 230 ? -19.394 22.772  20.617  1.000 21.190  0 230 ARG A NH2 1 ? 
ATOM   1823 N N   . ASP A 1 231 ? -18.135 19.294  19.641  1.000 17.492  0 231 ASP A N   1 ? 
ATOM   1824 C CA  . ASP A 1 231 ? -17.041 20.235  19.322  1.000 18.363  0 231 ASP A CA  1 ? 
ATOM   1825 C C   . ASP A 1 231 ? -16.100 19.573  18.320  1.000 17.089  0 231 ASP A C   1 ? 
ATOM   1826 O O   . ASP A 1 231 ? -15.713 20.268  17.366  1.000 18.298  0 231 ASP A O   1 ? 
ATOM   1827 C CB  . ASP A 1 231 ? -16.324 20.730  20.571  1.000 19.227  0 231 ASP A CB  1 ? 
ATOM   1828 C CG  . ASP A 1 231 ? -15.188 21.663  20.237  1.000 22.079  0 231 ASP A CG  1 ? 
ATOM   1829 O OD1 . ASP A 1 231 ? -15.475 22.700  19.672  1.000 25.076  0 231 ASP A OD1 1 ? 
ATOM   1830 O OD2 . ASP A 1 231 ? -14.029 21.271  20.427  1.000 24.925  0 231 ASP A OD2 1 ? 
ATOM   1831 N N   . ALA A 1 232 ? -15.758 18.294  18.480  1.000 17.055  0 232 ALA A N   1 ? 
ATOM   1832 C CA  . ALA A 1 232 ? -14.831 17.622  17.527  1.000 17.291  0 232 ALA A CA  1 ? 
ATOM   1833 C C   . ALA A 1 232 ? -15.436 17.674  16.125  1.000 17.779  0 232 ALA A C   1 ? 
ATOM   1834 O O   . ALA A 1 232 ? -14.707 17.974  15.159  1.000 17.708  0 232 ALA A O   1 ? 
ATOM   1835 C CB  . ALA A 1 232 ? -14.520 16.213  17.940  1.000 18.517  0 232 ALA A CB  1 ? 
ATOM   1836 N N   . LEU A 1 233 ? -16.731 17.401  16.016  1.000 17.159  0 233 LEU A N   1 ? 
ATOM   1837 C CA  . LEU A 1 233 ? -17.459 17.433  14.722  1.000 16.578  0 233 LEU A CA  1 ? 
ATOM   1838 C C   . LEU A 1 233 ? -17.515 18.863  14.179  1.000 17.991  0 233 LEU A C   1 ? 
ATOM   1839 O O   . LEU A 1 233 ? -17.293 19.049  12.961  1.000 16.536  0 233 LEU A O   1 ? 
ATOM   1840 C CB  . LEU A 1 233 ? -18.873 16.871  14.905  1.000 16.170  0 233 LEU A CB  1 ? 
ATOM   1841 C CG  . LEU A 1 233 ? -19.002 15.354  14.953  1.000 18.044  0 233 LEU A CG  1 ? 
ATOM   1842 C CD1 . LEU A 1 233 ? -20.451 14.947  15.257  1.000 19.575  0 233 LEU A CD1 1 ? 
ATOM   1843 C CD2 . LEU A 1 233 ? -18.567 14.708  13.635  1.000 19.150  0 233 LEU A CD2 1 ? 
ATOM   1844 N N   . GLU A 1 234 ? -17.793 19.858  15.026  1.000 17.428  0 234 GLU A N   1 ? 
ATOM   1845 C CA  . GLU A 1 234 ? -17.853 21.251  14.555  1.000 19.027  0 234 GLU A CA  1 ? 
ATOM   1846 C C   . GLU A 1 234 ? -16.521 21.664  13.964  1.000 19.016  0 234 GLU A C   1 ? 
ATOM   1847 O O   . GLU A 1 234 ? -16.514 22.271  12.859  1.000 17.770  0 234 GLU A O   1 ? 
ATOM   1848 C CB  . GLU A 1 234 ? -18.211 22.223  15.684  1.000 20.979  0 234 GLU A CB  1 ? 
ATOM   1849 C CG  . GLU A 1 234 ? -18.371 23.647  15.198  1.000 21.003  0 234 GLU A CG  1 ? 
ATOM   1850 C CD  . GLU A 1 234 ? -18.452 24.686  16.301  1.000 23.848  0 234 GLU A CD  1 ? 
ATOM   1851 O OE1 . GLU A 1 234 ? -18.975 24.356  17.389  1.000 24.065  0 234 GLU A OE1 1 ? 
ATOM   1852 O OE2 . GLU A 1 234 ? -17.947 25.795  16.081  1.000 27.255  0 234 GLU A OE2 1 ? 
ATOM   1853 N N   . GLN A 1 235 ? -15.419 21.422  14.677  1.000 19.679  0 235 GLN A N   1 ? 
ATOM   1854 C CA  . GLN A 1 235 ? -14.086 21.751  14.153  1.000 19.057  0 235 GLN A CA  1 ? 
ATOM   1855 C C   . GLN A 1 235 ? -13.852 20.999  12.830  1.000 18.796  0 235 GLN A C   1 ? 
ATOM   1856 O O   . GLN A 1 235 ? -13.243 21.564  11.867  1.000 19.489  0 235 GLN A O   1 ? 
ATOM   1857 C CB  . GLN A 1 235 ? -12.997 21.401  15.168  1.000 21.696  0 235 GLN A CB  1 ? 
ATOM   1858 C CG  . GLN A 1 235 ? -12.979 22.310  16.389  1.000 26.427  0 235 GLN A CG  1 ? 
ATOM   1859 C CD  . GLN A 1 235 ? -11.771 21.961  17.233  1.000 33.908  0 235 GLN A CD  1 ? 
ATOM   1860 O OE1 . GLN A 1 235 ? -10.627 21.926  16.739  1.000 35.328  0 235 GLN A OE1 1 ? 
ATOM   1861 N NE2 . GLN A 1 235 ? -12.018 21.589  18.487  1.000 37.883  0 235 GLN A NE2 1 ? 
ATOM   1862 N N   . PHE A 1 236 ? -14.157 19.728  12.806  1.000 17.240  0 236 PHE A N   1 ? 
ATOM   1863 C CA  . PHE A 1 236 ? -13.841 18.881  11.637  1.000 16.582  0 236 PHE A CA  1 ? 
ATOM   1864 C C   . PHE A 1 236 ? -14.658 19.378  10.435  1.000 16.101  0 236 PHE A C   1 ? 
ATOM   1865 O O   . PHE A 1 236 ? -14.095 19.567  9.351   1.000 15.688  0 236 PHE A O   1 ? 
ATOM   1866 C CB  . PHE A 1 236 ? -14.107 17.426  11.986  1.000 18.721  0 236 PHE A CB  1 ? 
ATOM   1867 C CG  . PHE A 1 236 ? -13.972 16.491  10.820  1.000 21.299  0 236 PHE A CG  1 ? 
ATOM   1868 C CD1 . PHE A 1 236 ? -12.897 16.595  9.964   1.000 18.980  0 236 PHE A CD1 1 ? 
ATOM   1869 C CD2 . PHE A 1 236 ? -14.832 15.421  10.677  1.000 26.622  0 236 PHE A CD2 1 ? 
ATOM   1870 C CE1 . PHE A 1 236 ? -12.766 15.733  8.892   1.000 21.207  0 236 PHE A CE1 1 ? 
ATOM   1871 C CE2 . PHE A 1 236 ? -14.669 14.528  9.625   1.000 28.886  0 236 PHE A CE2 1 ? 
ATOM   1872 C CZ  . PHE A 1 236 ? -13.643 14.710  8.715   1.000 26.088  0 236 PHE A CZ  1 ? 
ATOM   1873 N N   . VAL A 1 237 ? -15.944 19.661  10.635  1.000 15.487  0 237 VAL A N   1 ? 
ATOM   1874 C CA  . VAL A 1 237 ? -16.815 20.110  9.511   1.000 15.939  0 237 VAL A CA  1 ? 
ATOM   1875 C C   . VAL A 1 237 ? -16.327 21.461  8.991   1.000 15.704  0 237 VAL A C   1 ? 
ATOM   1876 O O   . VAL A 1 237 ? -16.239 21.604  7.783   1.000 16.404  0 237 VAL A O   1 ? 
ATOM   1877 C CB  . VAL A 1 237 ? -18.299 20.124  9.889   1.000 15.289  0 237 VAL A CB  1 ? 
ATOM   1878 C CG1 . VAL A 1 237 ? -19.139 20.811  8.820   1.000 15.545  0 237 VAL A CG1 1 ? 
ATOM   1879 C CG2 . VAL A 1 237 ? -18.799 18.715  10.138  1.000 15.925  0 237 VAL A CG2 1 ? 
ATOM   1880 N N   . GLN A 1 238 ? -15.992 22.396  9.885   1.000 18.132  0 238 GLN A N   1 ? 
ATOM   1881 C CA  . GLN A 1 238 ? -15.459 23.730  9.525   1.000 18.497  0 238 GLN A CA  1 ? 
ATOM   1882 C C   . GLN A 1 238 ? -14.187 23.517  8.704   1.000 18.679  0 238 GLN A C   1 ? 
ATOM   1883 O O   . GLN A 1 238 ? -14.035 24.172  7.671   1.000 19.027  0 238 GLN A O   1 ? 
ATOM   1884 C CB  . GLN A 1 238 ? -15.173 24.580  10.774  1.000 20.838  0 238 GLN A CB  1 ? 
ATOM   1885 C CG  . GLN A 1 238 ? -14.691 26.000  10.493  1.000 22.073  0 238 GLN A CG  1 ? 
ATOM   1886 C CD  . GLN A 1 238 ? -15.800 26.783  9.821   1.000 24.968  0 238 GLN A CD  1 ? 
ATOM   1887 O OE1 . GLN A 1 238 ? -16.782 27.149  10.452  1.000 33.476  0 238 GLN A OE1 1 ? 
ATOM   1888 N NE2 . GLN A 1 238 ? -15.704 26.917  8.517   1.000 26.888  0 238 GLN A NE2 1 ? 
ATOM   1889 N N   . THR A 1 239 ? -13.296 22.631  9.144   1.000 19.399  0 239 THR A N   1 ? 
ATOM   1890 C CA  . THR A 1 239 ? -12.029 22.380  8.414   1.000 19.823  0 239 THR A CA  1 ? 
ATOM   1891 C C   . THR A 1 239 ? -12.336 21.818  7.029   1.000 19.143  0 239 THR A C   1 ? 
ATOM   1892 O O   . THR A 1 239 ? -11.740 22.303  6.058   1.000 18.982  0 239 THR A O   1 ? 
ATOM   1893 C CB  . THR A 1 239 ? -11.056 21.528  9.234   1.000 19.877  0 239 THR A CB  1 ? 
ATOM   1894 O OG1 . THR A 1 239 ? -10.814 22.259  10.431  1.000 19.964  0 239 THR A OG1 1 ? 
ATOM   1895 C CG2 . THR A 1 239 ? -9.758  21.299  8.506   1.000 19.576  0 239 THR A CG2 1 ? 
ATOM   1896 N N   . MET A 1 240 ? -13.266 20.867  6.894   1.000 19.953  0 240 MET A N   1 ? 
ATOM   1897 C CA  . MET A 1 240 ? -13.604 20.352  5.541   1.000 18.232  0 240 MET A CA  1 ? 
ATOM   1898 C C   . MET A 1 240 ? -14.080 21.520  4.680   1.000 17.464  0 240 MET A C   1 ? 
ATOM   1899 O O   . MET A 1 240 ? -13.600 21.634  3.550   1.000 15.668  0 240 MET A O   1 ? 
ATOM   1900 C CB  . MET A 1 240 ? -14.662 19.260  5.553   1.000 21.641  0 240 MET A CB  1 ? 
ATOM   1901 C CG  . MET A 1 240 ? -14.111 17.905  5.939   1.000 25.108  0 240 MET A CG  1 ? 
ATOM   1902 S SD  . MET A 1 240 ? -15.359 16.594  5.697   1.000 27.792  0 240 MET A SD  1 ? 
ATOM   1903 C CE  . MET A 1 240 ? -16.293 16.786  7.196   1.000 28.910  0 240 MET A CE  1 ? 
ATOM   1904 N N   . LEU A 1 241 ? -14.927 22.393  5.222   1.000 17.688  0 241 LEU A N   1 ? 
ATOM   1905 C CA  . LEU A 1 241 ? -15.503 23.534  4.465   1.000 19.308  0 241 LEU A CA  1 ? 
ATOM   1906 C C   . LEU A 1 241 ? -14.366 24.489  4.053   1.000 19.269  0 241 LEU A C   1 ? 
ATOM   1907 O O   . LEU A 1 241 ? -14.387 24.909  2.934   1.000 18.099  0 241 LEU A O   1 ? 
ATOM   1908 C CB  . LEU A 1 241 ? -16.556 24.256  5.305   1.000 19.167  0 241 LEU A CB  1 ? 
ATOM   1909 C CG  . LEU A 1 241 ? -17.920 23.559  5.384   1.000 19.745  0 241 LEU A CG  1 ? 
ATOM   1910 C CD1 . LEU A 1 241 ? -18.764 24.216  6.452   1.000 19.937  0 241 LEU A CD1 1 ? 
ATOM   1911 C CD2 . LEU A 1 241 ? -18.629 23.581  4.025   1.000 19.640  0 241 LEU A CD2 1 ? 
ATOM   1912 N N   . ASP A 1 242 ? -13.380 24.691  4.910   1.000 20.484  0 242 ASP A N   1 ? 
ATOM   1913 C CA  . ASP A 1 242 ? -12.189 25.537  4.648   1.000 23.218  0 242 ASP A CA  1 ? 
ATOM   1914 C C   . ASP A 1 242 ? -11.369 24.974  3.490   1.000 24.919  0 242 ASP A C   1 ? 
ATOM   1915 O O   . ASP A 1 242 ? -10.603 25.739  2.901   1.000 26.143  0 242 ASP A O   1 ? 
ATOM   1916 C CB  . ASP A 1 242 ? -11.298 25.698  5.888   1.000 24.001  0 242 ASP A CB  1 ? 
ATOM   1917 C CG  . ASP A 1 242 ? -11.943 26.500  7.027   1.000 26.898  0 242 ASP A CG  1 ? 
ATOM   1918 O OD1 . ASP A 1 242 ? -12.985 27.095  6.801   1.000 28.903  0 242 ASP A OD1 1 ? 
ATOM   1919 O OD2 . ASP A 1 242 ? -11.434 26.442  8.158   1.000 31.265  0 242 ASP A OD2 1 ? 
ATOM   1920 N N   . ASN A 1 243 ? -11.544 23.717  3.128   1.000 22.299  0 243 ASN A N   1 ? 
ATOM   1921 C CA  . ASN A 1 243 ? -10.678 23.075  2.125   1.000 22.801  0 243 ASN A CA  1 ? 
ATOM   1922 C C   . ASN A 1 243 ? -11.375 22.970  0.761   1.000 25.590  0 243 ASN A C   1 ? 
ATOM   1923 O O   . ASN A 1 243 ? -10.749 22.435  -0.190  1.000 24.078  0 243 ASN A O   1 ? 
ATOM   1924 C CB  . ASN A 1 243 ? -10.175 21.745  2.653   1.000 23.217  0 243 ASN A CB  1 ? 
ATOM   1925 C CG  . ASN A 1 243 ? -8.923  21.923  3.491   1.000 23.166  0 243 ASN A CG  1 ? 
ATOM   1926 O OD1 . ASN A 1 243 ? -7.831  21.975  2.951   1.000 20.439  0 243 ASN A OD1 1 ? 
ATOM   1927 N ND2 . ASN A 1 243 ? -9.072  21.981  4.805   1.000 21.998  0 243 ASN A ND2 1 ? 
ATOM   1928 N N   . PHE A 1 244 ? -12.606 23.460  0.630   1.000 24.029  0 244 PHE A N   1 ? 
ATOM   1929 C CA  . PHE A 1 244 ? -13.244 23.635  -0.698  1.000 25.608  0 244 PHE A CA  1 ? 
ATOM   1930 C C   . PHE A 1 244 ? -12.470 24.735  -1.431  1.000 28.948  0 244 PHE A C   1 ? 
ATOM   1931 O O   . PHE A 1 244 ? -12.092 25.734  -0.788  1.000 27.883  0 244 PHE A O   1 ? 
ATOM   1932 C CB  . PHE A 1 244 ? -14.736 23.982  -0.569  1.000 24.002  0 244 PHE A CB  1 ? 
ATOM   1933 C CG  . PHE A 1 244 ? -15.657 22.803  -0.382  1.000 20.749  0 244 PHE A CG  1 ? 
ATOM   1934 C CD1 . PHE A 1 244 ? -15.794 22.199  0.851   1.000 18.773  0 244 PHE A CD1 1 ? 
ATOM   1935 C CD2 . PHE A 1 244 ? -16.476 22.369  -1.420  1.000 21.256  0 244 PHE A CD2 1 ? 
ATOM   1936 C CE1 . PHE A 1 244 ? -16.669 21.144  1.035   1.000 19.266  0 244 PHE A CE1 1 ? 
ATOM   1937 C CE2 . PHE A 1 244 ? -17.326 21.292  -1.251  1.000 19.772  0 244 PHE A CE2 1 ? 
ATOM   1938 C CZ  . PHE A 1 244 ? -17.448 20.694  -0.016  1.000 21.015  0 244 PHE A CZ  1 ? 
ATOM   1939 N N   . HIS A 1 245 ? -12.175 24.541  -2.708  1.000 31.003  0 245 HIS A N   1 ? 
ATOM   1940 C CA  . HIS A 1 245 ? -11.645 25.616  -3.598  1.000 40.624  0 245 HIS A CA  1 ? 
ATOM   1941 C C   . HIS A 1 245 ? -12.663 25.952  -4.708  1.000 50.662  0 245 HIS A C   1 ? 
ATOM   1942 O O   . HIS A 1 245 ? -13.621 25.155  -4.922  1.000 51.551  0 245 HIS A O   1 ? 
ATOM   1943 C CB  . HIS A 1 245 ? -10.274 25.228  -4.169  1.000 43.874  0 245 HIS A CB  1 ? 
ATOM   1944 C CG  . HIS A 1 245 ? -10.285 23.958  -4.940  1.000 51.028  0 245 HIS A CG  1 ? 
ATOM   1945 N ND1 . HIS A 1 245 ? -9.441  22.907  -4.632  1.000 56.644  0 245 HIS A ND1 1 ? 
ATOM   1946 C CD2 . HIS A 1 245 ? -11.071 23.541  -5.965  1.000 55.459  0 245 HIS A CD2 1 ? 
ATOM   1947 C CE1 . HIS A 1 245 ? -9.700  21.898  -5.440  1.000 55.423  0 245 HIS A CE1 1 ? 
ATOM   1948 N NE2 . HIS A 1 245 ? -10.700 22.263  -6.265  1.000 54.636  0 245 HIS A NE2 1 ? 
ATOM   1949 N N   . ASP A 1 246 ? -12.456 27.076  -5.412  1.000 63.386  0 246 ASP A N   1 ? 
ATOM   1950 C CA  . ASP A 1 246 ? -13.225 27.450  -6.633  1.000 72.277  0 246 ASP A CA  1 ? 
ATOM   1951 C C   . ASP A 1 246 ? -12.435 27.010  -7.881  1.000 79.512  0 246 ASP A C   1 ? 
ATOM   1952 O O   . ASP A 1 246 ? -11.276 27.458  -8.040  1.000 86.157  0 246 ASP A O   1 ? 
ATOM   1953 C CB  . ASP A 1 246 ? -13.567 28.946  -6.644  1.000 75.680  0 246 ASP A CB  1 ? 
ATOM   1954 C CG  . ASP A 1 246 ? -15.060 29.215  -6.768  1.000 82.157  0 246 ASP A CG  1 ? 
ATOM   1955 O OD1 . ASP A 1 246 ? -15.613 29.079  -7.896  1.000 81.979  0 246 ASP A OD1 1 ? 
ATOM   1956 O OD2 . ASP A 1 246 ? -15.669 29.496  -5.730  1.000 82.519  0 246 ASP A OD2 1 ? 
ATOM   1957 N N   . GLY A 1 247 ? -13.027 26.132  -8.705  1.000 83.905  0 247 GLY A N   1 ? 
ATOM   1958 C CA  . GLY A 1 247 ? -12.610 25.846  -10.095 1.000 81.939  0 247 GLY A CA  1 ? 
ATOM   1959 C C   . GLY A 1 247 ? -13.709 26.260  -11.057 1.000 84.363  0 247 GLY A C   1 ? 
ATOM   1960 O O   . GLY A 1 247 ? -13.949 27.475  -11.179 1.000 89.396  0 247 GLY A O   1 ? 
ATOM   1961 N N   . SER A 1 248 ? -14.398 25.287  -11.661 1.000 87.407  0 248 SER A N   1 ? 
ATOM   1962 C CA  . SER A 1 248 ? -15.697 25.460  -12.377 1.000 89.775  0 248 SER A CA  1 ? 
ATOM   1963 C C   . SER A 1 248 ? -16.755 26.011  -11.398 1.000 83.587  0 248 SER A C   1 ? 
ATOM   1964 O O   . SER A 1 248 ? -17.385 27.048  -11.714 1.000 79.619  0 248 SER A O   1 ? 
ATOM   1965 C CB  . SER A 1 248 ? -16.137 24.149  -13.016 1.000 85.474  0 248 SER A CB  1 ? 
ATOM   1966 O OG  . SER A 1 248 ? -17.163 24.362  -13.973 1.000 81.679  0 248 SER A OG  1 ? 
ATOM   1967 N N   . GLY A 1 249 ? -16.951 25.311  -10.272 1.000 73.420  0 249 GLY A N   1 ? 
ATOM   1968 C CA  . GLY A 1 249 ? -17.616 25.781  -9.038  1.000 56.424  0 249 GLY A CA  1 ? 
ATOM   1969 C C   . GLY A 1 249 ? -16.848 25.240  -7.841  1.000 47.760  0 249 GLY A C   1 ? 
ATOM   1970 O O   . GLY A 1 249 ? -15.766 24.683  -8.016  1.000 42.258  0 249 GLY A O   1 ? 
ATOM   1971 N N   . PRO A 1 250 ? -17.379 25.330  -6.608  1.000 47.025  0 250 PRO A N   1 ? 
ATOM   1972 C CA  . PRO A 1 250 ? -16.620 24.903  -5.421  1.000 45.413  0 250 PRO A CA  1 ? 
ATOM   1973 C C   . PRO A 1 250 ? -16.469 23.363  -5.367  1.000 35.158  0 250 PRO A C   1 ? 
ATOM   1974 O O   . PRO A 1 250 ? -17.416 22.666  -5.682  1.000 38.615  0 250 PRO A O   1 ? 
ATOM   1975 C CB  . PRO A 1 250 ? -17.475 25.493  -4.281  1.000 49.909  0 250 PRO A CB  1 ? 
ATOM   1976 C CG  . PRO A 1 250 ? -18.916 25.402  -4.824  1.000 49.970  0 250 PRO A CG  1 ? 
ATOM   1977 C CD  . PRO A 1 250 ? -18.765 25.733  -6.296  1.000 51.877  0 250 PRO A CD  1 ? 
ATOM   1978 N N   . ARG A 1 251 ? -15.245 22.859  -5.202  1.000 32.179  0 251 ARG A N   1 ? 
ATOM   1979 C CA  . ARG A 1 251 ? -14.965 21.413  -5.059  1.000 28.052  0 251 ARG A CA  1 ? 
ATOM   1980 C C   . ARG A 1 251 ? -14.056 21.183  -3.860  1.000 25.426  0 251 ARG A C   1 ? 
ATOM   1981 O O   . ARG A 1 251 ? -13.091 21.943  -3.649  1.000 23.061  0 251 ARG A O   1 ? 
ATOM   1982 C CB  . ARG A 1 251 ? -14.255 20.775  -6.263  1.000 29.468  0 251 ARG A CB  1 ? 
ATOM   1983 C CG  . ARG A 1 251 ? -15.113 20.579  -7.501  1.000 30.176  0 251 ARG A CG  1 ? 
ATOM   1984 C CD  . ARG A 1 251 ? -14.462 19.654  -8.509  1.000 28.869  0 251 ARG A CD  1 ? 
ATOM   1985 N NE  . ARG A 1 251 ? -14.554 18.277  -8.073  1.000 28.137  0 251 ARG A NE  1 ? 
ATOM   1986 C CZ  . ARG A 1 251 ? -15.541 17.442  -8.359  1.000 25.273  0 251 ARG A CZ  1 ? 
ATOM   1987 N NH1 . ARG A 1 251 ? -16.546 17.834  -9.129  1.000 27.542  0 251 ARG A NH1 1 ? 
ATOM   1988 N NH2 . ARG A 1 251 ? -15.531 16.219  -7.861  1.000 23.223  0 251 ARG A NH2 1 ? 
ATOM   1989 N N   . LEU A 1 252 ? -14.304 20.080  -3.195  1.000 21.270  0 252 LEU A N   1 ? 
ATOM   1990 C CA  . LEU A 1 252 ? -13.412 19.532  -2.157  1.000 22.444  0 252 LEU A CA  1 ? 
ATOM   1991 C C   . LEU A 1 252 ? -12.677 18.353  -2.786  1.000 20.537  0 252 LEU A C   1 ? 
ATOM   1992 O O   . LEU A 1 252 ? -13.341 17.391  -3.245  1.000 20.896  0 252 LEU A O   1 ? 
ATOM   1993 C CB  . LEU A 1 252 ? -14.255 19.175  -0.925  1.000 19.601  0 252 LEU A CB  1 ? 
ATOM   1994 C CG  . LEU A 1 252 ? -13.475 18.622  0.265   1.000 22.396  0 252 LEU A CG  1 ? 
ATOM   1995 C CD1 . LEU A 1 252 ? -12.457 19.625  0.788   1.000 19.769  0 252 LEU A CD1 1 ? 
ATOM   1996 C CD2 . LEU A 1 252 ? -14.431 18.139  1.367   1.000 20.700  0 252 LEU A CD2 1 ? 
ATOM   1997 N N   . THR A 1 253 ? -11.358 18.508  -2.950  1.000 19.077  0 253 THR A N   1 ? 
ATOM   1998 C CA  . THR A 1 253 ? -10.455 17.470  -3.479  1.000 18.776  0 253 THR A CA  1 ? 
ATOM   1999 C C   . THR A 1 253 ? -9.685  16.886  -2.299  1.000 22.544  0 253 THR A C   1 ? 
ATOM   2000 O O   . THR A 1 253 ? -9.094  17.674  -1.569  1.000 27.312  0 253 THR A O   1 ? 
ATOM   2001 C CB  . THR A 1 253 ? -9.528  18.053  -4.537  1.000 21.579  0 253 THR A CB  1 ? 
ATOM   2002 O OG1 . THR A 1 253 ? -10.359 18.652  -5.520  1.000 25.744  0 253 THR A OG1 1 ? 
ATOM   2003 C CG2 . THR A 1 253 ? -8.639  17.022  -5.185  1.000 22.606  0 253 THR A CG2 1 ? 
ATOM   2004 N N   . VAL A 1 254 ? -9.799  15.584  -2.048  1.000 20.939  0 254 VAL A N   1 ? 
ATOM   2005 C CA  . VAL A 1 254 ? -9.130  14.919  -0.899  1.000 21.634  0 254 VAL A CA  1 ? 
ATOM   2006 C C   . VAL A 1 254 ? -8.369  13.702  -1.403  1.000 20.972  0 254 VAL A C   1 ? 
ATOM   2007 O O   . VAL A 1 254 ? -9.001  12.700  -1.791  1.000 19.786  0 254 VAL A O   1 ? 
ATOM   2008 C CB  . VAL A 1 254 ? -10.113 14.503  0.189   1.000 22.775  0 254 VAL A CB  1 ? 
ATOM   2009 C CG1 . VAL A 1 254 ? -9.377  13.866  1.330   1.000 24.518  0 254 VAL A CG1 1 ? 
ATOM   2010 C CG2 . VAL A 1 254 ? -10.957 15.666  0.670   1.000 24.822  0 254 VAL A CG2 1 ? 
ATOM   2011 N N   . GLU A 1 255 ? -7.051  13.764  -1.348  1.000 17.785  0 255 GLU A N   1 ? 
ATOM   2012 C CA  . GLU A 1 255 ? -6.205  12.630  -1.752  1.000 18.640  0 255 GLU A CA  1 ? 
ATOM   2013 C C   . GLU A 1 255 ? -6.374  11.472  -0.766  1.000 16.814  0 255 GLU A C   1 ? 
ATOM   2014 O O   . GLU A 1 255 ? -6.289  11.676  0.451   1.000 16.464  0 255 GLU A O   1 ? 
ATOM   2015 C CB  . GLU A 1 255 ? -4.746  13.039  -1.728  1.000 19.402  0 255 GLU A CB  1 ? 
ATOM   2016 C CG  . GLU A 1 255 ? -4.291  13.756  -2.958  1.000 19.506  0 255 GLU A CG  1 ? 
ATOM   2017 C CD  . GLU A 1 255 ? -4.930  15.093  -3.269  1.000 21.302  0 255 GLU A CD  1 ? 
ATOM   2018 O OE1 . GLU A 1 255 ? -5.194  15.924  -2.293  1.000 20.191  0 255 GLU A OE1 1 ? 
ATOM   2019 O OE2 . GLU A 1 255 ? -5.064  15.346  -4.488  1.000 20.400  0 255 GLU A OE2 1 ? 
ATOM   2020 N N   . LEU A 1 256 ? -6.475  10.275  -1.270  1.000 17.294  0 256 LEU A N   1 ? 
ATOM   2021 C CA  . LEU A 1 256 ? -6.138  9.095   -0.457  1.000 19.649  0 256 LEU A CA  1 ? 
ATOM   2022 C C   . LEU A 1 256 ? -4.691  9.261   0.027   1.000 20.485  0 256 LEU A C   1 ? 
ATOM   2023 O O   . LEU A 1 256 ? -3.820  9.794   -0.703  1.000 21.650  0 256 LEU A O   1 ? 
ATOM   2024 C CB  . LEU A 1 256 ? -6.382  7.869   -1.333  1.000 20.583  0 256 LEU A CB  1 ? 
ATOM   2025 C CG  . LEU A 1 256 ? -6.513  6.562   -0.578  1.000 22.897  0 256 LEU A CG  1 ? 
ATOM   2026 C CD1 . LEU A 1 256 ? -7.835  6.481   0.153   1.000 22.905  0 256 LEU A CD1 1 ? 
ATOM   2027 C CD2 . LEU A 1 256 ? -6.342  5.389   -1.521  1.000 23.822  0 256 LEU A CD2 1 ? 
ATOM   2028 N N   . PRO A 1 257 ? -4.398  9.014   1.325   1.000 20.502  0 257 PRO A N   1 ? 
ATOM   2029 C CA  . PRO A 1 257 ? -3.030  9.210   1.840   1.000 18.967  0 257 PRO A CA  1 ? 
ATOM   2030 C C   . PRO A 1 257 ? -2.020  8.097   1.526   1.000 20.418  0 257 PRO A C   1 ? 
ATOM   2031 O O   . PRO A 1 257 ? -0.928  8.158   2.014   1.000 20.111  0 257 PRO A O   1 ? 
ATOM   2032 C CB  . PRO A 1 257 ? -3.247  9.306   3.355   1.000 19.483  0 257 PRO A CB  1 ? 
ATOM   2033 C CG  . PRO A 1 257 ? -4.491  8.497   3.595   1.000 20.601  0 257 PRO A CG  1 ? 
ATOM   2034 C CD  . PRO A 1 257 ? -5.375  8.767   2.402   1.000 19.199  0 257 PRO A CD  1 ? 
ATOM   2035 N N   . VAL A 1 258 ? -2.427  7.122   0.725   1.000 19.329  0 258 VAL A N   1 ? 
ATOM   2036 C CA  . VAL A 1 258 ? -1.594  6.015   0.180   1.000 19.109  0 258 VAL A CA  1 ? 
ATOM   2037 C C   . VAL A 1 258 ? -1.882  5.935   -1.302  1.000 19.147  0 258 VAL A C   1 ? 
ATOM   2038 O O   . VAL A 1 258 ? -2.856  6.609   -1.777  1.000 19.098  0 258 VAL A O   1 ? 
ATOM   2039 C CB  . VAL A 1 258 ? -1.913  4.671   0.870   1.000 18.884  0 258 VAL A CB  1 ? 
ATOM   2040 C CG1 . VAL A 1 258 ? -1.600  4.700   2.343   1.000 22.712  0 258 VAL A CG1 1 ? 
ATOM   2041 C CG2 . VAL A 1 258 ? -3.348  4.248   0.678   1.000 18.509  0 258 VAL A CG2 1 ? 
ATOM   2042 N N   . GLN A 1 259 ? -1.127  5.098   -2.005  1.000 20.114  0 259 GLN A N   1 ? 
ATOM   2043 C CA  . GLN A 1 259 ? -1.368  4.760   -3.431  1.000 19.811  0 259 GLN A CA  1 ? 
ATOM   2044 C C   . GLN A 1 259 ? -2.829  4.376   -3.625  1.000 17.645  0 259 GLN A C   1 ? 
ATOM   2045 O O   . GLN A 1 259 ? -3.375  3.617   -2.844  1.000 17.429  0 259 GLN A O   1 ? 
ATOM   2046 C CB  . GLN A 1 259 ? -0.480  3.578   -3.838  1.000 23.579  0 259 GLN A CB  1 ? 
ATOM   2047 C CG  . GLN A 1 259 ? 0.991   3.938   -3.936  1.000 25.042  0 259 GLN A CG  1 ? 
ATOM   2048 C CD  . GLN A 1 259 ? 1.274   4.701   -5.208  1.000 28.275  0 259 GLN A CD  1 ? 
ATOM   2049 O OE1 . GLN A 1 259 ? 0.375   5.176   -5.905  1.000 26.203  0 259 GLN A OE1 1 ? 
ATOM   2050 N NE2 . GLN A 1 259 ? 2.548   4.829   -5.515  1.000 30.077  0 259 GLN A NE2 1 ? 
ATOM   2051 N N   . PRO A 1 260 ? -3.484  4.803   -4.717  1.000 16.724  0 260 PRO A N   1 ? 
ATOM   2052 C CA  . PRO A 1 260 ? -2.857  5.632   -5.741  1.000 18.406  0 260 PRO A CA  1 ? 
ATOM   2053 C C   . PRO A 1 260 ? -3.037  7.164   -5.583  1.000 18.408  0 260 PRO A C   1 ? 
ATOM   2054 O O   . PRO A 1 260 ? -2.947  7.886   -6.572  1.000 20.750  0 260 PRO A O   1 ? 
ATOM   2055 C CB  . PRO A 1 260 ? -3.638  5.106   -6.954  1.000 18.782  0 260 PRO A CB  1 ? 
ATOM   2056 C CG  . PRO A 1 260 ? -5.029  5.016   -6.437  1.000 18.260  0 260 PRO A CG  1 ? 
ATOM   2057 C CD  . PRO A 1 260 ? -4.856  4.405   -5.071  1.000 18.115  0 260 PRO A CD  1 ? 
ATOM   2058 N N   . TYR A 1 261 ? -3.344  7.660   -4.387  1.000 17.735  0 261 TYR A N   1 ? 
ATOM   2059 C CA  . TYR A 1 261 ? -3.384  9.122   -4.108  1.000 18.463  0 261 TYR A CA  1 ? 
ATOM   2060 C C   . TYR A 1 261 ? -4.465  9.782   -4.971  1.000 19.561  0 261 TYR A C   1 ? 
ATOM   2061 O O   . TYR A 1 261 ? -4.320  10.908  -5.361  1.000 19.956  0 261 TYR A O   1 ? 
ATOM   2062 C CB  . TYR A 1 261 ? -2.010  9.738   -4.363  1.000 18.093  0 261 TYR A CB  1 ? 
ATOM   2063 C CG  . TYR A 1 261 ? -0.915  9.150   -3.513  1.000 17.541  0 261 TYR A CG  1 ? 
ATOM   2064 C CD1 . TYR A 1 261 ? -0.838  9.471   -2.174  1.000 20.108  0 261 TYR A CD1 1 ? 
ATOM   2065 C CD2 . TYR A 1 261 ? 0.023   8.257   -4.025  1.000 18.978  0 261 TYR A CD2 1 ? 
ATOM   2066 C CE1 . TYR A 1 261 ? 0.138   8.932   -1.354  1.000 20.720  0 261 TYR A CE1 1 ? 
ATOM   2067 C CE2 . TYR A 1 261 ? 1.013   7.716   -3.219  1.000 19.073  0 261 TYR A CE2 1 ? 
ATOM   2068 C CZ  . TYR A 1 261 ? 1.057   8.053   -1.879  1.000 19.109  0 261 TYR A CZ  1 ? 
ATOM   2069 O OH  . TYR A 1 261 ? 2.005   7.581   -1.041  1.000 22.127  0 261 TYR A OH  1 ? 
ATOM   2070 N N   . ASN A 1 262 ? -5.515  9.045   -5.286  1.000 20.746  0 262 ASN A N   1 ? 
ATOM   2071 C CA  . ASN A 1 262 ? -6.644  9.567   -6.093  1.000 20.693  0 262 ASN A CA  1 ? 
ATOM   2072 C C   . ASN A 1 262 ? -7.486  10.510  -5.211  1.000 18.939  0 262 ASN A C   1 ? 
ATOM   2073 O O   . ASN A 1 262 ? -7.450  10.396  -3.959  1.000 16.395  0 262 ASN A O   1 ? 
ATOM   2074 C CB  . ASN A 1 262 ? -7.463  8.412   -6.662  1.000 20.902  0 262 ASN A CB  1 ? 
ATOM   2075 C CG  . ASN A 1 262 ? -8.123  7.637   -5.555  1.000 23.877  0 262 ASN A CG  1 ? 
ATOM   2076 O OD1 . ASN A 1 262 ? -7.452  6.919   -4.810  1.000 22.487  0 262 ASN A OD1 1 ? 
ATOM   2077 N ND2 . ASN A 1 262 ? -9.431  7.791   -5.424  1.000 22.722  0 262 ASN A ND2 1 ? 
ATOM   2078 N N   . ASP A 1 263 ? -8.168  11.462  -5.830  1.000 20.704  0 263 ASP A N   1 ? 
ATOM   2079 C CA  . ASP A 1 263 ? -9.171  12.316  -5.146  1.000 21.082  0 263 ASP A CA  1 ? 
ATOM   2080 C C   . ASP A 1 263 ? -10.370 11.426  -4.815  1.000 20.049  0 263 ASP A C   1 ? 
ATOM   2081 O O   . ASP A 1 263 ? -11.007 10.936  -5.744  1.000 19.279  0 263 ASP A O   1 ? 
ATOM   2082 C CB  . ASP A 1 263 ? -9.562  13.518  -6.009  1.000 23.876  0 263 ASP A CB  1 ? 
ATOM   2083 C CG  . ASP A 1 263 ? -10.769 14.295  -5.516  1.000 22.170  0 263 ASP A CG  1 ? 
ATOM   2084 O OD1 . ASP A 1 263 ? -11.182 14.121  -4.318  1.000 18.970  0 263 ASP A OD1 1 ? 
ATOM   2085 O OD2 . ASP A 1 263 ? -11.274 15.074  -6.312  1.000 22.612  0 263 ASP A OD2 1 ? 
ATOM   2086 N N   . VAL A 1 264 ? -10.625 11.188  -3.539  1.000 20.197  0 264 VAL A N   1 ? 
ATOM   2087 C CA  . VAL A 1 264 ? -11.717 10.276  -3.074  1.000 20.955  0 264 VAL A CA  1 ? 
ATOM   2088 C C   . VAL A 1 264 ? -13.100 10.820  -3.488  1.000 23.159  0 264 VAL A C   1 ? 
ATOM   2089 O O   . VAL A 1 264 ? -14.071 10.011  -3.475  1.000 25.932  0 264 VAL A O   1 ? 
ATOM   2090 C CB  . VAL A 1 264 ? -11.641 10.028  -1.559  1.000 21.485  0 264 VAL A CB  1 ? 
ATOM   2091 C CG1 . VAL A 1 264 ? -10.321 9.386   -1.176  1.000 20.802  0 264 VAL A CG1 1 ? 
ATOM   2092 C CG2 . VAL A 1 264 ? -11.897 11.305  -0.750  1.000 25.093  0 264 VAL A CG2 1 ? 
ATOM   2093 N N   . PHE A 1 265 ? -13.222 12.101  -3.842  1.000 22.184  0 265 PHE A N   1 ? 
ATOM   2094 C CA  . PHE A 1 265 ? -14.523 12.735  -4.195  1.000 22.984  0 265 PHE A CA  1 ? 
ATOM   2095 C C   . PHE A 1 265 ? -14.609 13.014  -5.706  1.000 22.723  0 265 PHE A C   1 ? 
ATOM   2096 O O   . PHE A 1 265 ? -15.527 13.712  -6.124  1.000 21.910  0 265 PHE A O   1 ? 
ATOM   2097 C CB  . PHE A 1 265 ? -14.748 14.002  -3.385  1.000 22.149  0 265 PHE A CB  1 ? 
ATOM   2098 C CG  . PHE A 1 265 ? -14.883 13.765  -1.914  1.000 22.209  0 265 PHE A CG  1 ? 
ATOM   2099 C CD1 . PHE A 1 265 ? -15.668 12.739  -1.434  1.000 23.457  0 265 PHE A CD1 1 ? 
ATOM   2100 C CD2 . PHE A 1 265 ? -14.181 14.533  -1.009  1.000 23.868  0 265 PHE A CD2 1 ? 
ATOM   2101 C CE1 . PHE A 1 265 ? -15.780 12.514  -0.075  1.000 25.028  0 265 PHE A CE1 1 ? 
ATOM   2102 C CE2 . PHE A 1 265 ? -14.286 14.293  0.350   1.000 24.592  0 265 PHE A CE2 1 ? 
ATOM   2103 C CZ  . PHE A 1 265 ? -15.102 13.300  0.809   1.000 23.244  0 265 PHE A CZ  1 ? 
ATOM   2104 N N   . GLU A 1 266 ? -13.742 12.398  -6.502  1.000 25.387  0 266 GLU A N   1 ? 
ATOM   2105 C CA  . GLU A 1 266 ? -13.562 12.743  -7.942  1.000 29.074  0 266 GLU A CA  1 ? 
ATOM   2106 C C   . GLU A 1 266 ? -14.853 12.455  -8.727  1.000 27.972  0 266 GLU A C   1 ? 
ATOM   2107 O O   . GLU A 1 266 ? -15.094 13.160  -9.678  1.000 28.448  0 266 GLU A O   1 ? 
ATOM   2108 C CB  . GLU A 1 266 ? -12.361 11.987  -8.552  1.000 31.664  0 266 GLU A CB  1 ? 
ATOM   2109 C CG  . GLU A 1 266 ? -12.453 10.471  -8.456  1.000 35.975  0 266 GLU A CG  1 ? 
ATOM   2110 C CD  . GLU A 1 266 ? -11.151 9.688   -8.706  1.000 42.198  0 266 GLU A CD  1 ? 
ATOM   2111 O OE1 . GLU A 1 266 ? -10.341 10.134  -9.531  1.000 43.385  0 266 GLU A OE1 1 ? 
ATOM   2112 O OE2 . GLU A 1 266 ? -10.960 8.628   -8.071  1.000 43.387  0 266 GLU A OE2 1 ? 
ATOM   2113 N N   . LYS A 1 267 ? -15.632 11.440  -8.354  1.000 29.867  0 267 LYS A N   1 ? 
ATOM   2114 C CA  . LYS A 1 267 ? -16.818 10.983  -9.137  1.000 35.017  0 267 LYS A CA  1 ? 
ATOM   2115 C C   . LYS A 1 267 ? -17.981 11.973  -8.947  1.000 35.252  0 267 LYS A C   1 ? 
ATOM   2116 O O   . LYS A 1 267 ? -18.895 11.951  -9.753  1.000 28.717  0 267 LYS A O   1 ? 
ATOM   2117 C CB  . LYS A 1 267 ? -17.260 9.573   -8.727  1.000 40.996  0 267 LYS A CB  1 ? 
ATOM   2118 C CG  . LYS A 1 267 ? -16.276 8.443   -9.037  1.000 50.524  0 267 LYS A CG  1 ? 
ATOM   2119 C CD  . LYS A 1 267 ? -15.621 8.530   -10.405 1.000 57.172  0 267 LYS A CD  1 ? 
ATOM   2120 C CE  . LYS A 1 267 ? -14.836 7.279   -10.762 1.000 63.462  0 267 LYS A CE  1 ? 
ATOM   2121 N NZ  . LYS A 1 267 ? -14.384 7.286   -12.174 1.000 62.496  0 267 LYS A NZ  1 ? 
ATOM   2122 N N   . MET A 1 268 ? -17.956 12.808  -7.914  1.000 28.014  0 268 MET A N   1 ? 
ATOM   2123 C CA  . MET A 1 268 ? -19.058 13.754  -7.661  1.000 29.491  0 268 MET A CA  1 ? 
ATOM   2124 C C   . MET A 1 268 ? -19.059 14.790  -8.765  1.000 27.214  0 268 MET A C   1 ? 
ATOM   2125 O O   . MET A 1 268 ? -18.003 15.272  -9.093  1.000 26.370  0 268 MET A O   1 ? 
ATOM   2126 C CB  . MET A 1 268 ? -18.934 14.394  -6.271  1.000 33.746  0 268 MET A CB  1 ? 
ATOM   2127 C CG  . MET A 1 268 ? -19.163 13.343  -5.182  1.000 34.420  0 268 MET A CG  1 ? 
ATOM   2128 S SD  . MET A 1 268 ? -19.135 13.948  -3.493  1.000 40.057  0 268 MET A SD  1 ? 
ATOM   2129 C CE  . MET A 1 268 ? -19.995 15.483  -3.745  1.000 30.581  0 268 MET A CE  1 ? 
ATOM   2130 N N   . THR A 1 269 ? -20.229 15.048  -9.355  1.000 24.921  0 269 THR A N   1 ? 
ATOM   2131 C CA  . THR A 1 269 ? -20.423 16.116  -10.352 1.000 23.894  0 269 THR A CA  1 ? 
ATOM   2132 C C   . THR A 1 269 ? -20.262 17.455  -9.659  1.000 24.450  0 269 THR A C   1 ? 
ATOM   2133 O O   . THR A 1 269 ? -20.301 17.472  -8.438  1.000 22.866  0 269 THR A O   1 ? 
ATOM   2134 C CB  . THR A 1 269 ? -21.815 16.053  -10.997 1.000 25.968  0 269 THR A CB  1 ? 
ATOM   2135 O OG1 . THR A 1 269 ? -22.741 16.287  -9.939  1.000 23.422  0 269 THR A OG1 1 ? 
ATOM   2136 C CG2 . THR A 1 269 ? -22.100 14.738  -11.689 1.000 28.970  0 269 THR A CG2 1 ? 
ATOM   2137 N N   . GLY A 1 270 ? -20.128 18.521  -10.432 1.000 22.188  0 270 GLY A N   1 ? 
ATOM   2138 C CA  . GLY A 1 270 ? -20.165 19.905  -9.937  1.000 23.227  0 270 GLY A CA  1 ? 
ATOM   2139 C C   . GLY A 1 270 ? -21.366 20.157  -9.036  1.000 22.391  0 270 GLY A C   1 ? 
ATOM   2140 O O   . GLY A 1 270 ? -21.180 20.767  -7.959  1.000 21.193  0 270 GLY A O   1 ? 
ATOM   2141 N N   . MET A 1 271 ? -22.565 19.807  -9.477  1.000 21.681  0 271 MET A N   1 ? 
ATOM   2142 C CA  . MET A 1 271 ? -23.811 20.103  -8.721  1.000 26.194  0 271 MET A CA  1 ? 
ATOM   2143 C C   . MET A 1 271 ? -23.828 19.255  -7.420  1.000 19.835  0 271 MET A C   1 ? 
ATOM   2144 O O   . MET A 1 271 ? -24.230 19.754  -6.374  1.000 19.050  0 271 MET A O   1 ? 
ATOM   2145 C CB  . MET A 1 271 ? -25.067 19.792  -9.552  1.000 31.312  0 271 MET A CB  1 ? 
ATOM   2146 C CG  . MET A 1 271 ? -26.371 20.294  -8.868  1.000 41.745  0 271 MET A CG  1 ? 
ATOM   2147 S SD  . MET A 1 271 ? -26.470 22.144  -8.555  1.000 51.465  0 271 MET A SD  1 ? 
ATOM   2148 C CE  . MET A 1 271 ? -25.517 22.832  -9.914  1.000 38.299  0 271 MET A CE  1 ? 
ATOM   2149 N N   . GLN A 1 272 ? -23.365 18.031  -7.472  1.000 20.011  0 272 GLN A N   1 ? 
ATOM   2150 C CA  . GLN A 1 272 ? -23.306 17.168  -6.265  1.000 20.034  0 272 GLN A CA  1 ? 
ATOM   2151 C C   . GLN A 1 272 ? -22.312 17.775  -5.268  1.000 19.589  0 272 GLN A C   1 ? 
ATOM   2152 O O   . GLN A 1 272 ? -22.624 17.806  -4.078  1.000 17.166  0 272 GLN A O   1 ? 
ATOM   2153 C CB  . GLN A 1 272 ? -22.923 15.745  -6.657  1.000 22.257  0 272 GLN A CB  1 ? 
ATOM   2154 C CG  . GLN A 1 272 ? -23.998 15.049  -7.482  1.000 23.779  0 272 GLN A CG  1 ? 
ATOM   2155 C CD  . GLN A 1 272 ? -23.541 13.764  -8.128  1.000 25.237  0 272 GLN A CD  1 ? 
ATOM   2156 O OE1 . GLN A 1 272 ? -22.355 13.489  -8.300  1.000 21.438  0 272 GLN A OE1 1 ? 
ATOM   2157 N NE2 . GLN A 1 272 ? -24.506 12.926  -8.459  1.000 28.660  0 272 GLN A NE2 1 ? 
ATOM   2158 N N   . MET A 1 273 ? -21.184 18.288  -5.735  1.000 18.845  0 273 MET A N   1 ? 
ATOM   2159 C CA  . MET A 1 273 ? -20.204 19.004  -4.875  1.000 19.244  0 273 MET A CA  1 ? 
ATOM   2160 C C   . MET A 1 273 ? -20.877 20.203  -4.205  1.000 18.082  0 273 MET A C   1 ? 
ATOM   2161 O O   . MET A 1 273 ? -20.672 20.399  -3.034  1.000 16.653  0 273 MET A O   1 ? 
ATOM   2162 C CB  . MET A 1 273 ? -19.016 19.508  -5.697  1.000 21.187  0 273 MET A CB  1 ? 
ATOM   2163 C CG  . MET A 1 273 ? -17.846 18.603  -5.572  1.000 25.882  0 273 MET A CG  1 ? 
ATOM   2164 S SD  . MET A 1 273 ? -17.234 18.470  -3.838  1.000 25.093  0 273 MET A SD  1 ? 
ATOM   2165 C CE  . MET A 1 273 ? -16.572 16.823  -4.016  1.000 25.170  0 273 MET A CE  1 ? 
ATOM   2166 N N   . GLU A 1 274 ? -21.600 21.028  -4.957  1.000 17.764  0 274 GLU A N   1 ? 
ATOM   2167 C CA  . GLU A 1 274 ? -22.261 22.229  -4.402  1.000 18.631  0 274 GLU A CA  1 ? 
ATOM   2168 C C   . GLU A 1 274 ? -23.311 21.794  -3.363  1.000 17.749  0 274 GLU A C   1 ? 
ATOM   2169 O O   . GLU A 1 274 ? -23.426 22.437  -2.325  1.000 19.301  0 274 GLU A O   1 ? 
ATOM   2170 C CB  . GLU A 1 274 ? -22.874 23.022  -5.556  1.000 20.111  0 274 GLU A CB  1 ? 
ATOM   2171 C CG  . GLU A 1 274 ? -23.356 24.369  -5.149  1.000 23.250  0 274 GLU A CG  1 ? 
ATOM   2172 C CD  . GLU A 1 274 ? -24.101 25.157  -6.225  1.000 24.424  0 274 GLU A CD  1 ? 
ATOM   2173 O OE1 . GLU A 1 274 ? -24.093 24.723  -7.362  1.000 28.334  0 274 GLU A OE1 1 ? 
ATOM   2174 O OE2 . GLU A 1 274 ? -24.673 26.193  -5.900  1.000 27.988  0 274 GLU A OE2 1 ? 
ATOM   2175 N N   . SER A 1 275 ? -24.064 20.740  -3.649  1.000 17.419  0 275 SER A N   1 ? 
ATOM   2176 C CA  . SER A 1 275 ? -25.081 20.213  -2.719  1.000 18.823  0 275 SER A CA  1 ? 
ATOM   2177 C C   . SER A 1 275 ? -24.365 19.657  -1.471  1.000 20.040  0 275 SER A C   1 ? 
ATOM   2178 O O   . SER A 1 275 ? -24.765 19.981  -0.324  1.000 19.082  0 275 SER A O   1 ? 
ATOM   2179 C CB  . SER A 1 275 ? -25.928 19.207  -3.380  1.000 18.107  0 275 SER A CB  1 ? 
ATOM   2180 O OG  . SER A 1 275 ? -26.782 18.602  -2.437  1.000 20.898  0 275 SER A OG  1 ? 
ATOM   2181 N N   . PHE A 1 276 ? -23.296 18.909  -1.680  1.000 18.366  0 276 PHE A N   1 ? 
ATOM   2182 C CA  . PHE A 1 276 ? -22.435 18.409  -0.591  1.000 18.680  0 276 PHE A CA  1 ? 
ATOM   2183 C C   . PHE A 1 276 ? -22.024 19.576  0.321   1.000 16.240  0 276 PHE A C   1 ? 
ATOM   2184 O O   . PHE A 1 276 ? -22.209 19.466  1.542   1.000 17.075  0 276 PHE A O   1 ? 
ATOM   2185 C CB  . PHE A 1 276 ? -21.261 17.634  -1.176  1.000 18.514  0 276 PHE A CB  1 ? 
ATOM   2186 C CG  . PHE A 1 276 ? -20.240 17.118  -0.201  1.000 18.322  0 276 PHE A CG  1 ? 
ATOM   2187 C CD1 . PHE A 1 276 ? -20.599 16.671  1.051   1.000 19.117  0 276 PHE A CD1 1 ? 
ATOM   2188 C CD2 . PHE A 1 276 ? -18.921 16.958  -0.603  1.000 22.421  0 276 PHE A CD2 1 ? 
ATOM   2189 C CE1 . PHE A 1 276 ? -19.658 16.102  1.901   1.000 20.431  0 276 PHE A CE1 1 ? 
ATOM   2190 C CE2 . PHE A 1 276 ? -17.980 16.410  0.256   1.000 22.296  0 276 PHE A CE2 1 ? 
ATOM   2191 C CZ  . PHE A 1 276 ? -18.353 15.978  1.501   1.000 20.580  0 276 PHE A CZ  1 ? 
ATOM   2192 N N   . LYS A 1 277 ? -21.508 20.659  -0.235  1.000 15.713  0 277 LYS A N   1 ? 
ATOM   2193 C CA  . LYS A 1 277 ? -21.057 21.832  0.546   1.000 17.646  0 277 LYS A CA  1 ? 
ATOM   2194 C C   . LYS A 1 277 ? -22.247 22.420  1.310   1.000 16.293  0 277 LYS A C   1 ? 
ATOM   2195 O O   . LYS A 1 277 ? -22.100 22.790  2.448   1.000 15.953  0 277 LYS A O   1 ? 
ATOM   2196 C CB  . LYS A 1 277 ? -20.455 22.888  -0.387  1.000 20.049  0 277 LYS A CB  1 ? 
ATOM   2197 C CG  . LYS A 1 277 ? -19.827 24.071  0.333   1.000 25.398  0 277 LYS A CG  1 ? 
ATOM   2198 C CD  . LYS A 1 277 ? -19.109 25.106  -0.547  1.000 27.673  0 277 LYS A CD  1 ? 
ATOM   2199 C CE  . LYS A 1 277 ? -18.745 26.298  0.304   1.000 37.609  0 277 LYS A CE  1 ? 
ATOM   2200 N NZ  . LYS A 1 277 ? -17.674 27.109  -0.315  1.000 48.475  0 277 LYS A NZ  1 ? 
ATOM   2201 N N   . SER A 1 278 ? -23.384 22.597  0.662   1.000 16.467  0 278 SER A N   1 ? 
ATOM   2202 C CA  . SER A 1 278 ? -24.543 23.252  1.331   1.000 17.792  0 278 SER A CA  1 ? 
ATOM   2203 C C   . SER A 1 278 ? -24.999 22.386  2.526   1.000 16.191  0 278 SER A C   1 ? 
ATOM   2204 O O   . SER A 1 278 ? -25.349 22.956  3.570   1.000 16.240  0 278 SER A O   1 ? 
ATOM   2205 C CB  . SER A 1 278 ? -25.654 23.517  0.333   1.000 19.374  0 278 SER A CB  1 ? 
ATOM   2206 O OG  . SER A 1 278 ? -26.211 22.275  -0.101  1.000 24.711  0 278 SER A OG  1 ? 
ATOM   2207 N N   . LYS A 1 279 ? -24.968 21.055  2.392   1.000 16.015  0 279 LYS A N   1 ? 
ATOM   2208 C CA  . LYS A 1 279 ? -25.392 20.125  3.488   1.000 17.160  0 279 LYS A CA  1 ? 
ATOM   2209 C C   . LYS A 1 279 ? -24.349 20.143  4.617   1.000 17.234  0 279 LYS A C   1 ? 
ATOM   2210 O O   . LYS A 1 279 ? -24.746 20.051  5.795   1.000 15.278  0 279 LYS A O   1 ? 
ATOM   2211 C CB  . LYS A 1 279 ? -25.649 18.716  2.954   1.000 18.131  0 279 LYS A CB  1 ? 
ATOM   2212 C CG  . LYS A 1 279 ? -26.835 18.617  2.006   1.000 18.827  0 279 LYS A CG  1 ? 
ATOM   2213 C CD  . LYS A 1 279 ? -26.956 17.303  1.261   1.000 18.078  0 279 LYS A CD  1 ? 
ATOM   2214 C CE  . LYS A 1 279 ? -28.329 17.204  0.587   1.000 18.717  0 279 LYS A CE  1 ? 
ATOM   2215 N NZ  . LYS A 1 279 ? -28.504 15.894  -0.087  1.000 19.221  0 279 LYS A NZ  1 ? 
ATOM   2216 N N   . LEU A 1 280 ? -23.070 20.374  4.293   1.000 18.670  0 280 LEU A N   1 ? 
ATOM   2217 C CA  . LEU A 1 280 ? -22.025 20.513  5.338   1.000 17.204  0 280 LEU A CA  1 ? 
ATOM   2218 C C   . LEU A 1 280 ? -22.283 21.803  6.088   1.000 16.770  0 280 LEU A C   1 ? 
ATOM   2219 O O   . LEU A 1 280 ? -22.126 21.804  7.316   1.000 17.480  0 280 LEU A O   1 ? 
ATOM   2220 C CB  . LEU A 1 280 ? -20.629 20.530  4.703   1.000 19.153  0 280 LEU A CB  1 ? 
ATOM   2221 C CG  . LEU A 1 280 ? -20.052 19.169  4.366   1.000 19.562  0 280 LEU A CG  1 ? 
ATOM   2222 C CD1 . LEU A 1 280 ? -18.832 19.330  3.487   1.000 19.064  0 280 LEU A CD1 1 ? 
ATOM   2223 C CD2 . LEU A 1 280 ? -19.698 18.394  5.651   1.000 21.270  0 280 LEU A CD2 1 ? 
ATOM   2224 N N   . GLN A 1 281 ? -22.606 22.883  5.371   1.000 18.592  0 281 GLN A N   1 ? 
ATOM   2225 C CA  . GLN A 1 281 ? -22.865 24.202  6.001   1.000 18.780  0 281 GLN A CA  1 ? 
ATOM   2226 C C   . GLN A 1 281 ? -24.009 24.040  6.978   1.000 15.817  0 281 GLN A C   1 ? 
ATOM   2227 O O   . GLN A 1 281 ? -23.964 24.632  8.084   1.000 16.511  0 281 GLN A O   1 ? 
ATOM   2228 C CB  . GLN A 1 281 ? -23.247 25.299  5.006   1.000 21.458  0 281 GLN A CB  1 ? 
ATOM   2229 C CG  . GLN A 1 281 ? -22.164 25.658  4.011   1.000 23.819  0 281 GLN A CG  1 ? 
ATOM   2230 C CD  . GLN A 1 281 ? -21.113 26.616  4.538   1.000 27.163  0 281 GLN A CD  1 ? 
ATOM   2231 O OE1 . GLN A 1 281 ? -21.075 26.986  5.719   1.000 24.780  0 281 GLN A OE1 1 ? 
ATOM   2232 N NE2 . GLN A 1 281 ? -20.285 27.074  3.613   1.000 30.022  0 281 GLN A NE2 1 ? 
ATOM   2233 N N   . ALA A 1 282 ? -25.036 23.315  6.586   1.000 16.894  0 282 ALA A N   1 ? 
ATOM   2234 C CA  . ALA A 1 282 ? -26.256 23.211  7.414   1.000 16.491  0 282 ALA A CA  1 ? 
ATOM   2235 C C   . ALA A 1 282 ? -25.932 22.366  8.635   1.000 17.044  0 282 ALA A C   1 ? 
ATOM   2236 O O   . ALA A 1 282 ? -26.388 22.705  9.747   1.000 17.035  0 282 ALA A O   1 ? 
ATOM   2237 C CB  . ALA A 1 282 ? -27.395 22.648  6.584   1.000 17.228  0 282 ALA A CB  1 ? 
ATOM   2238 N N   . LEU A 1 283 ? -25.155 21.307  8.449   1.000 15.761  0 283 LEU A N   1 ? 
ATOM   2239 C CA  . LEU A 1 283 ? -24.712 20.459  9.587   1.000 16.653  0 283 LEU A CA  1 ? 
ATOM   2240 C C   . LEU A 1 283 ? -23.888 21.324  10.564  1.000 17.692  0 283 LEU A C   1 ? 
ATOM   2241 O O   . LEU A 1 283 ? -24.094 21.240  11.744  1.000 19.097  0 283 LEU A O   1 ? 
ATOM   2242 C CB  . LEU A 1 283 ? -23.897 19.284  9.045   1.000 16.540  0 283 LEU A CB  1 ? 
ATOM   2243 C CG  . LEU A 1 283 ? -23.172 18.448  10.095  1.000 15.357  0 283 LEU A CG  1 ? 
ATOM   2244 C CD1 . LEU A 1 283 ? -24.144 17.852  11.075  1.000 16.236  0 283 LEU A CD1 1 ? 
ATOM   2245 C CD2 . LEU A 1 283 ? -22.344 17.346  9.431   1.000 15.786  0 283 LEU A CD2 1 ? 
ATOM   2246 N N   . LEU A 1 284 ? -22.982 22.147  10.062  1.000 18.456  0 284 LEU A N   1 ? 
ATOM   2247 C CA  . LEU A 1 284 ? -22.167 23.045  10.901  1.000 17.988  0 284 LEU A CA  1 ? 
ATOM   2248 C C   . LEU A 1 284 ? -23.057 23.988  11.719  1.000 19.956  0 284 LEU A C   1 ? 
ATOM   2249 O O   . LEU A 1 284 ? -22.788 24.173  12.919  1.000 19.388  0 284 LEU A O   1 ? 
ATOM   2250 C CB  . LEU A 1 284 ? -21.238 23.840  10.011  1.000 18.852  0 284 LEU A CB  1 ? 
ATOM   2251 C CG  . LEU A 1 284 ? -20.314 24.800  10.755  1.000 20.788  0 284 LEU A CG  1 ? 
ATOM   2252 C CD1 . LEU A 1 284 ? -19.324 24.031  11.578  1.000 23.438  0 284 LEU A CD1 1 ? 
ATOM   2253 C CD2 . LEU A 1 284 ? -19.585 25.717  9.793   1.000 22.722  0 284 LEU A CD2 1 ? 
ATOM   2254 N N   . ASN A 1 285 ? -24.069 24.565  11.085  1.000 19.092  0 285 ASN A N   1 ? 
ATOM   2255 C CA  . ASN A 1 285 ? -25.064 25.442  11.741  1.000 20.865  0 285 ASN A CA  1 ? 
ATOM   2256 C C   . ASN A 1 285 ? -25.788 24.672  12.836  1.000 19.713  0 285 ASN A C   1 ? 
ATOM   2257 O O   . ASN A 1 285 ? -25.922 25.221  13.923  1.000 21.736  0 285 ASN A O   1 ? 
ATOM   2258 C CB  . ASN A 1 285 ? -26.043 26.043  10.721  1.000 20.616  0 285 ASN A CB  1 ? 
ATOM   2259 C CG  . ASN A 1 285 ? -25.378 27.096  9.865   1.000 24.931  0 285 ASN A CG  1 ? 
ATOM   2260 O OD1 . ASN A 1 285 ? -24.379 27.680  10.259  1.000 33.096  0 285 ASN A OD1 1 ? 
ATOM   2261 N ND2 . ASN A 1 285 ? -25.956 27.402  8.720   1.000 30.333  0 285 ASN A ND2 1 ? 
ATOM   2262 N N   . ALA A 1 286 ? -26.184 23.431  12.579  1.000 18.707  0 286 ALA A N   1 ? 
ATOM   2263 C CA  . ALA A 1 286 ? -26.861 22.567  13.570  1.000 18.996  0 286 ALA A CA  1 ? 
ATOM   2264 C C   . ALA A 1 286 ? -25.902 22.242  14.736  1.000 20.839  0 286 ALA A C   1 ? 
ATOM   2265 O O   . ALA A 1 286 ? -26.320 22.312  15.884  1.000 20.436  0 286 ALA A O   1 ? 
ATOM   2266 C CB  . ALA A 1 286 ? -27.342 21.305  12.901  1.000 20.375  0 286 ALA A CB  1 ? 
ATOM   2267 N N   . LEU A 1 287 ? -24.637 21.927  14.456  1.000 18.423  0 287 LEU A N   1 ? 
ATOM   2268 C CA  . LEU A 1 287 ? -23.640 21.712  15.538  1.000 19.448  0 287 LEU A CA  1 ? 
ATOM   2269 C C   . LEU A 1 287 ? -23.483 22.976  16.391  1.000 20.287  0 287 LEU A C   1 ? 
ATOM   2270 O O   . LEU A 1 287 ? -23.424 22.848  17.640  1.000 19.303  0 287 LEU A O   1 ? 
ATOM   2271 C CB  . LEU A 1 287 ? -22.313 21.268  14.932  1.000 17.991  0 287 LEU A CB  1 ? 
ATOM   2272 C CG  . LEU A 1 287 ? -22.367 19.885  14.301  1.000 16.658  0 287 LEU A CG  1 ? 
ATOM   2273 C CD1 . LEU A 1 287 ? -21.195 19.705  13.385  1.000 16.385  0 287 LEU A CD1 1 ? 
ATOM   2274 C CD2 . LEU A 1 287 ? -22.403 18.797  15.366  1.000 18.208  0 287 LEU A CD2 1 ? 
ATOM   2275 N N   . LYS A 1 288 ? -23.445 24.156  15.775  1.000 22.027  0 288 LYS A N   1 ? 
ATOM   2276 C CA  . LYS A 1 288 ? -23.321 25.423  16.538  1.000 23.165  0 288 LYS A CA  1 ? 
ATOM   2277 C C   . LYS A 1 288 ? -24.602 25.709  17.332  1.000 24.297  0 288 LYS A C   1 ? 
ATOM   2278 O O   . LYS A 1 288 ? -24.474 26.172  18.434  1.000 23.035  0 288 LYS A O   1 ? 
ATOM   2279 C CB  . LYS A 1 288 ? -23.013 26.585  15.601  1.000 25.504  0 288 LYS A CB  1 ? 
ATOM   2280 C CG  . LYS A 1 288 ? -21.590 26.561  15.101  1.000 27.542  0 288 LYS A CG  1 ? 
ATOM   2281 C CD  . LYS A 1 288 ? -21.336 27.589  14.034  1.000 27.751  0 288 LYS A CD  1 ? 
ATOM   2282 C CE  . LYS A 1 288 ? -19.874 27.660  13.678  1.000 28.303  0 288 LYS A CE  1 ? 
ATOM   2283 N NZ  . LYS A 1 288 ? -19.679 28.561  12.515  1.000 34.040  0 288 LYS A NZ  1 ? 
ATOM   2284 N N   . THR A 1 289 ? -25.786 25.498  16.756  1.000 23.731  0 289 THR A N   1 ? 
ATOM   2285 C CA  . THR A 1 289 ? -27.085 25.634  17.465  1.000 26.121  0 289 THR A CA  1 ? 
ATOM   2286 C C   . THR A 1 289 ? -27.127 24.722  18.691  1.000 26.691  0 289 THR A C   1 ? 
ATOM   2287 O O   . THR A 1 289 ? -27.591 25.179  19.735  1.000 28.271  0 289 THR A O   1 ? 
ATOM   2288 C CB  . THR A 1 289 ? -28.272 25.335  16.548  1.000 24.687  0 289 THR A CB  1 ? 
ATOM   2289 O OG1 . THR A 1 289 ? -28.218 26.364  15.574  1.000 28.468  0 289 THR A OG1 1 ? 
ATOM   2290 C CG2 . THR A 1 289 ? -29.613 25.359  17.243  1.000 30.829  0 289 THR A CG2 1 ? 
ATOM   2291 N N   . ALA A 1 290 ? -26.714 23.463  18.576  1.000 23.953  0 290 ALA A N   1 ? 
ATOM   2292 C CA  . ALA A 1 290 ? -26.701 22.547  19.739  1.000 23.093  0 290 ALA A CA  1 ? 
ATOM   2293 C C   . ALA A 1 290 ? -25.835 23.126  20.875  1.000 24.184  0 290 ALA A C   1 ? 
ATOM   2294 O O   . ALA A 1 290 ? -26.114 22.826  22.029  1.000 29.825  0 290 ALA A O   1 ? 
ATOM   2295 C CB  . ALA A 1 290 ? -26.271 21.167  19.363  1.000 21.765  0 290 ALA A CB  1 ? 
ATOM   2296 N N   . LYS A 1 291 ? -24.787 23.883  20.587  1.000 25.969  0 291 LYS A N   1 ? 
ATOM   2297 C CA  . LYS A 1 291 ? -23.980 24.505  21.663  1.000 29.021  0 291 LYS A CA  1 ? 
ATOM   2298 C C   . LYS A 1 291 ? -24.783 25.647  22.337  1.000 33.136  0 291 LYS A C   1 ? 
ATOM   2299 O O   . LYS A 1 291 ? -24.647 25.819  23.557  1.000 33.698  0 291 LYS A O   1 ? 
ATOM   2300 C CB  . LYS A 1 291 ? -22.645 25.001  21.118  1.000 30.471  0 291 LYS A CB  1 ? 
ATOM   2301 C CG  . LYS A 1 291 ? -21.653 25.428  22.190  1.000 33.432  0 291 LYS A CG  1 ? 
ATOM   2302 C CD  . LYS A 1 291 ? -20.485 26.171  21.622  1.000 37.304  0 291 LYS A CD  1 ? 
ATOM   2303 C CE  . LYS A 1 291 ? -19.371 26.359  22.621  1.000 45.358  0 291 LYS A CE  1 ? 
ATOM   2304 N NZ  . LYS A 1 291 ? -18.104 26.617  21.901  1.000 50.326  0 291 LYS A NZ  1 ? 
ATOM   2305 N N   . SER A 1 292 ? -25.506 26.462  21.567  1.000 32.356  0 292 SER A N   1 ? 
ATOM   2306 C CA  . SER A 1 292 ? -26.011 27.789  22.015  1.000 37.475  0 292 SER A CA  1 ? 
ATOM   2307 C C   . SER A 1 292 ? -27.406 27.648  22.647  1.000 36.852  0 292 SER A C   1 ? 
ATOM   2308 O O   . SER A 1 292 ? -27.687 28.395  23.574  1.000 40.408  0 292 SER A O   1 ? 
ATOM   2309 C CB  . SER A 1 292 ? -26.005 28.781  20.885  1.000 35.642  0 292 SER A CB  1 ? 
ATOM   2310 O OG  . SER A 1 292 ? -26.823 28.308  19.838  1.000 41.131  0 292 SER A OG  1 ? 
ATOM   2311 N N   . ARG A 1 293 ? -28.210 26.682  22.219  1.000 36.357  0 293 ARG A N   1 ? 
ATOM   2312 C CA  . ARG A 1 293 ? -29.552 26.424  22.808  1.000 38.048  0 293 ARG A CA  1 ? 
ATOM   2313 C C   . ARG A 1 293 ? -29.437 26.082  24.297  1.000 45.523  0 293 ARG A C   1 ? 
ATOM   2314 O O   . ARG A 1 293 ? -28.715 25.115  24.656  1.000 39.457  0 293 ARG A O   1 ? 
ATOM   2315 C CB  . ARG A 1 293 ? -30.281 25.318  22.051  1.000 41.997  0 293 ARG A CB  1 ? 
ATOM   2316 C CG  . ARG A 1 293 ? -30.750 25.758  20.675  1.000 48.668  0 293 ARG A CG  1 ? 
ATOM   2317 C CD  . ARG A 1 293 ? -31.901 26.751  20.741  1.000 57.222  0 293 ARG A CD  1 ? 
ATOM   2318 N NE  . ARG A 1 293 ? -32.128 27.372  19.443  1.000 68.517  0 293 ARG A NE  1 ? 
ATOM   2319 C CZ  . ARG A 1 293 ? -31.375 28.344  18.923  1.000 73.213  0 293 ARG A CZ  1 ? 
ATOM   2320 N NH1 . ARG A 1 293 ? -30.337 28.827  19.595  1.000 66.626  0 293 ARG A NH1 1 ? 
ATOM   2321 N NH2 . ARG A 1 293 ? -31.665 28.827  17.726  1.000 77.095  0 293 ARG A NH2 1 ? 
ATOM   2322 N N   . LEU A 1 294 ? -30.178 26.830  25.118  1.000 45.690  0 294 LEU A N   1 ? 
ATOM   2323 C CA  . LEU A 1 294 ? -30.387 26.604  26.573  1.000 45.241  0 294 LEU A CA  1 ? 
ATOM   2324 C C   . LEU A 1 294 ? -31.108 25.277  26.832  1.000 38.603  0 294 LEU A C   1 ? 
ATOM   2325 O O   . LEU A 1 294 ? -30.728 24.579  27.770  1.000 37.062  0 294 LEU A O   1 ? 
ATOM   2326 C CB  . LEU A 1 294 ? -31.190 27.783  27.133  1.000 49.333  0 294 LEU A CB  1 ? 
ATOM   2327 C CG  . LEU A 1 294 ? -30.366 29.026  27.514  1.000 55.622  0 294 LEU A CG  1 ? 
ATOM   2328 C CD1 . LEU A 1 294 ? -29.132 29.204  26.624  1.000 54.957  0 294 LEU A CD1 1 ? 
ATOM   2329 C CD2 . LEU A 1 294 ? -31.232 30.289  27.484  1.000 56.261  0 294 LEU A CD2 1 ? 
ATOM   2330 N N   . GLU A 1 295 ? -32.133 24.949  26.065  1.000 36.422  0 295 GLU A N   1 ? 
ATOM   2331 C CA  . GLU A 1 295 ? -32.959 23.739  26.318  1.000 40.066  0 295 GLU A CA  1 ? 
ATOM   2332 C C   . GLU A 1 295 ? -32.333 22.539  25.596  1.000 40.065  0 295 GLU A C   1 ? 
ATOM   2333 O O   . GLU A 1 295 ? -32.093 22.653  24.391  1.000 35.686  0 295 GLU A O   1 ? 
ATOM   2334 C CB  . GLU A 1 295 ? -34.391 23.943  25.833  1.000 43.201  0 295 GLU A CB  1 ? 
ATOM   2335 C CG  . GLU A 1 295 ? -35.168 24.963  26.631  1.000 54.685  0 295 GLU A CG  1 ? 
ATOM   2336 C CD  . GLU A 1 295 ? -36.234 24.327  27.504  1.000 63.413  0 295 GLU A CD  1 ? 
ATOM   2337 O OE1 . GLU A 1 295 ? -37.426 24.513  27.186  1.000 64.484  0 295 GLU A OE1 1 ? 
ATOM   2338 O OE2 . GLU A 1 295 ? -35.864 23.601  28.468  1.000 71.445  0 295 GLU A OE2 1 ? 
ATOM   2339 N N   . LEU A 1 296 ? -32.117 21.439  26.325  1.000 37.246  0 296 LEU A N   1 ? 
ATOM   2340 C CA  . LEU A 1 296 ? -31.561 20.162  25.816  1.000 36.419  0 296 LEU A CA  1 ? 
ATOM   2341 C C   . LEU A 1 296 ? -32.440 19.673  24.669  1.000 35.261  0 296 LEU A C   1 ? 
ATOM   2342 O O   . LEU A 1 296 ? -31.885 19.216  23.664  1.000 29.657  0 296 LEU A O   1 ? 
ATOM   2343 C CB  . LEU A 1 296 ? -31.501 19.129  26.952  1.000 34.897  0 296 LEU A CB  1 ? 
ATOM   2344 C CG  . LEU A 1 296 ? -30.897 17.768  26.590  1.000 34.959  0 296 LEU A CG  1 ? 
ATOM   2345 C CD1 . LEU A 1 296 ? -29.476 17.918  26.061  1.000 34.182  0 296 LEU A CD1 1 ? 
ATOM   2346 C CD2 . LEU A 1 296 ? -30.902 16.818  27.783  1.000 36.362  0 296 LEU A CD2 1 ? 
ATOM   2347 N N   . HIS A 1 297 ? -33.763 19.748  24.823  1.000 31.368  0 297 HIS A N   1 ? 
ATOM   2348 C CA  . HIS A 1 297 ? -34.734 19.390  23.759  1.000 29.308  0 297 HIS A CA  1 ? 
ATOM   2349 C C   . HIS A 1 297 ? -34.380 20.120  22.460  1.000 28.625  0 297 HIS A C   1 ? 
ATOM   2350 O O   . HIS A 1 297 ? -34.362 19.462  21.429  1.000 32.218  0 297 HIS A O   1 ? 
ATOM   2351 C CB  . HIS A 1 297 ? -36.182 19.682  24.176  1.000 32.097  0 297 HIS A CB  1 ? 
ATOM   2352 C CG  . HIS A 1 297 ? -37.163 19.417  23.095  1.000 30.703  0 297 HIS A CG  1 ? 
ATOM   2353 N ND1 . HIS A 1 297 ? -37.698 18.161  22.880  1.000 33.655  0 297 HIS A ND1 1 ? 
ATOM   2354 C CD2 . HIS A 1 297 ? -37.661 20.230  22.133  1.000 31.472  0 297 HIS A CD2 1 ? 
ATOM   2355 C CE1 . HIS A 1 297 ? -38.493 18.205  21.834  1.000 32.244  0 297 HIS A CE1 1 ? 
ATOM   2356 N NE2 . HIS A 1 297 ? -38.491 19.476  21.357  1.000 33.669  0 297 HIS A NE2 1 ? 
ATOM   2357 N N   . ASP A 1 298 ? -34.179 21.434  22.493  1.000 28.488  0 298 ASP A N   1 ? 
ATOM   2358 C CA  . ASP A 1 298 ? -33.972 22.214  21.247  1.000 31.931  0 298 ASP A CA  1 ? 
ATOM   2359 C C   . ASP A 1 298 ? -32.592 21.850  20.657  1.000 29.970  0 298 ASP A C   1 ? 
ATOM   2360 O O   . ASP A 1 298 ? -32.517 21.664  19.433  1.000 26.426  0 298 ASP A O   1 ? 
ATOM   2361 C CB  . ASP A 1 298 ? -34.088 23.722  21.465  1.000 33.679  0 298 ASP A CB  1 ? 
ATOM   2362 C CG  . ASP A 1 298 ? -35.452 24.203  21.966  1.000 38.302  0 298 ASP A CG  1 ? 
ATOM   2363 O OD1 . ASP A 1 298 ? -36.456 23.707  21.472  1.000 33.209  0 298 ASP A OD1 1 ? 
ATOM   2364 O OD2 . ASP A 1 298 ? -35.475 25.072  22.861  1.000 39.174  0 298 ASP A OD2 1 ? 
ATOM   2365 N N   . ALA A 1 299 ? -31.557 21.743  21.495  1.000 25.349  0 299 ALA A N   1 ? 
ATOM   2366 C CA  . ALA A 1 299 ? -30.195 21.360  21.062  1.000 26.664  0 299 ALA A CA  1 ? 
ATOM   2367 C C   . ALA A 1 299 ? -30.266 20.026  20.303  1.000 25.196  0 299 ALA A C   1 ? 
ATOM   2368 O O   . ALA A 1 299 ? -29.734 19.949  19.190  1.000 23.772  0 299 ALA A O   1 ? 
ATOM   2369 C CB  . ALA A 1 299 ? -29.261 21.279  22.237  1.000 28.330  0 299 ALA A CB  1 ? 
ATOM   2370 N N   . CYS A 1 300 ? -30.941 19.021  20.865  1.000 23.034  0 300 CYS A N   1 ? 
ATOM   2371 C CA  . CYS A 1 300 ? -30.953 17.651  20.311  1.000 22.775  0 300 CYS A CA  1 ? 
ATOM   2372 C C   . CYS A 1 300 ? -31.849 17.581  19.070  1.000 25.200  0 300 CYS A C   1 ? 
ATOM   2373 O O   . CYS A 1 300 ? -31.554 16.810  18.170  1.000 22.618  0 300 CYS A O   1 ? 
ATOM   2374 C CB  . CYS A 1 300 ? -31.402 16.653  21.357  1.000 23.121  0 300 CYS A CB  1 ? 
ATOM   2375 S SG  . CYS A 1 300 ? -30.179 16.513  22.664  1.000 27.511  0 300 CYS A SG  1 ? 
ATOM   2376 N N   . LYS A 1 301 ? -32.890 18.394  18.998  1.000 26.617  0 301 LYS A N   1 ? 
ATOM   2377 C CA  . LYS A 1 301 ? -33.780 18.397  17.818  1.000 28.382  0 301 LYS A CA  1 ? 
ATOM   2378 C C   . LYS A 1 301 ? -33.014 18.965  16.628  1.000 22.245  0 301 LYS A C   1 ? 
ATOM   2379 O O   . LYS A 1 301 ? -33.191 18.467  15.527  1.000 24.411  0 301 LYS A O   1 ? 
ATOM   2380 C CB  . LYS A 1 301 ? -35.056 19.192  18.115  1.000 34.363  0 301 LYS A CB  1 ? 
ATOM   2381 C CG  . LYS A 1 301 ? -36.128 19.086  17.032  1.000 38.788  0 301 LYS A CG  1 ? 
ATOM   2382 C CD  . LYS A 1 301 ? -36.162 20.308  16.130  1.000 47.570  0 301 LYS A CD  1 ? 
ATOM   2383 C CE  . LYS A 1 301 ? -37.300 20.291  15.132  1.000 51.800  0 301 LYS A CE  1 ? 
ATOM   2384 N NZ  . LYS A 1 301 ? -36.938 21.023  13.893  1.000 50.819  0 301 LYS A NZ  1 ? 
ATOM   2385 N N   . ALA A 1 302 ? -32.174 19.965  16.856  1.000 23.674  0 302 ALA A N   1 ? 
ATOM   2386 C CA  . ALA A 1 302 ? -31.334 20.572  15.808  1.000 24.259  0 302 ALA A CA  1 ? 
ATOM   2387 C C   . ALA A 1 302 ? -30.396 19.499  15.250  1.000 25.105  0 302 ALA A C   1 ? 
ATOM   2388 O O   . ALA A 1 302 ? -30.155 19.502  14.031  1.000 23.666  0 302 ALA A O   1 ? 
ATOM   2389 C CB  . ALA A 1 302 ? -30.580 21.750  16.357  1.000 24.786  0 302 ALA A CB  1 ? 
ATOM   2390 N N   . LEU A 1 303 ? -29.937 18.571  16.092  1.000 22.024  0 303 LEU A N   1 ? 
ATOM   2391 C CA  . LEU A 1 303 ? -28.992 17.526  15.634  1.000 21.241  0 303 LEU A CA  1 ? 
ATOM   2392 C C   . LEU A 1 303 ? -29.755 16.409  14.912  1.000 19.834  0 303 LEU A C   1 ? 
ATOM   2393 O O   . LEU A 1 303 ? -29.268 15.912  13.897  1.000 19.807  0 303 LEU A O   1 ? 
ATOM   2394 C CB  . LEU A 1 303 ? -28.207 17.019  16.848  1.000 20.709  0 303 LEU A CB  1 ? 
ATOM   2395 C CG  . LEU A 1 303 ? -27.240 18.036  17.436  1.000 20.565  0 303 LEU A CG  1 ? 
ATOM   2396 C CD1 . LEU A 1 303 ? -26.608 17.493  18.712  1.000 22.220  0 303 LEU A CD1 1 ? 
ATOM   2397 C CD2 . LEU A 1 303 ? -26.177 18.443  16.417  1.000 22.507  0 303 LEU A CD2 1 ? 
ATOM   2398 N N   . ALA A 1 304 ? -30.927 16.040  15.403  1.000 23.156  0 304 ALA A N   1 ? 
ATOM   2399 C CA  . ALA A 1 304 ? -31.782 14.988  14.811  1.000 21.860  0 304 ALA A CA  1 ? 
ATOM   2400 C C   . ALA A 1 304 ? -32.157 15.379  13.387  1.000 21.593  0 304 ALA A C   1 ? 
ATOM   2401 O O   . ALA A 1 304 ? -32.373 14.444  12.557  1.000 24.172  0 304 ALA A O   1 ? 
ATOM   2402 C CB  . ALA A 1 304 ? -33.007 14.735  15.655  1.000 24.840  0 304 ALA A CB  1 ? 
ATOM   2403 N N   . ASP A 1 305 ? -32.254 16.669  13.101  1.000 21.360  0 305 ASP A N   1 ? 
ATOM   2404 C CA  . ASP A 1 305 ? -32.608 17.166  11.743  1.000 22.164  0 305 ASP A CA  1 ? 
ATOM   2405 C C   . ASP A 1 305 ? -31.509 16.743  10.766  1.000 24.265  0 305 ASP A C   1 ? 
ATOM   2406 O O   . ASP A 1 305 ? -31.783 16.691  9.567   1.000 20.889  0 305 ASP A O   1 ? 
ATOM   2407 C CB  . ASP A 1 305 ? -32.849 18.667  11.765  1.000 25.645  0 305 ASP A CB  1 ? 
ATOM   2408 C CG  . ASP A 1 305 ? -34.136 19.073  12.505  1.000 29.022  0 305 ASP A CG  1 ? 
ATOM   2409 O OD1 . ASP A 1 305 ? -35.015 18.233  12.633  1.000 34.519  0 305 ASP A OD1 1 ? 
ATOM   2410 O OD2 . ASP A 1 305 ? -34.220 20.188  12.949  1.000 31.623  0 305 ASP A OD2 1 ? 
ATOM   2411 N N   . HIS A 1 306 ? -30.290 16.442  11.239  1.000 22.266  0 306 HIS A N   1 ? 
ATOM   2412 C CA  . HIS A 1 306 ? -29.157 16.098  10.316  1.000 24.789  0 306 HIS A CA  1 ? 
ATOM   2413 C C   . HIS A 1 306 ? -28.693 14.662  10.521  1.000 21.132  0 306 HIS A C   1 ? 
ATOM   2414 O O   . HIS A 1 306 ? -28.232 14.067  9.563   1.000 19.836  0 306 HIS A O   1 ? 
ATOM   2415 C CB  . HIS A 1 306 ? -28.022 17.124  10.456  1.000 24.058  0 306 HIS A CB  1 ? 
ATOM   2416 C CG  . HIS A 1 306 ? -28.505 18.488  10.126  1.000 24.252  0 306 HIS A CG  1 ? 
ATOM   2417 N ND1 . HIS A 1 306 ? -28.530 18.966  8.820   1.000 23.368  0 306 HIS A ND1 1 ? 
ATOM   2418 C CD2 . HIS A 1 306 ? -29.125 19.423  10.889  1.000 23.680  0 306 HIS A CD2 1 ? 
ATOM   2419 C CE1 . HIS A 1 306 ? -29.122 20.144  8.817   1.000 22.654  0 306 HIS A CE1 1 ? 
ATOM   2420 N NE2 . HIS A 1 306 ? -29.441 20.461  10.076  1.000 20.085  0 306 HIS A NE2 1 ? 
ATOM   2421 N N   . PHE A 1 307 ? -28.784 14.134  11.732  1.000 21.004  0 307 PHE A N   1 ? 
ATOM   2422 C CA  . PHE A 1 307 ? -28.346 12.752  12.038  1.000 22.578  0 307 PHE A CA  1 ? 
ATOM   2423 C C   . PHE A 1 307 ? -29.509 11.750  11.946  1.000 23.478  0 307 PHE A C   1 ? 
ATOM   2424 O O   . PHE A 1 307 ? -29.232 10.514  11.949  1.000 20.790  0 307 PHE A O   1 ? 
ATOM   2425 C CB  . PHE A 1 307 ? -27.638 12.722  13.390  1.000 22.513  0 307 PHE A CB  1 ? 
ATOM   2426 C CG  . PHE A 1 307 ? -26.293 13.407  13.360  1.000 21.856  0 307 PHE A CG  1 ? 
ATOM   2427 C CD1 . PHE A 1 307 ? -25.249 12.880  12.603  1.000 19.999  0 307 PHE A CD1 1 ? 
ATOM   2428 C CD2 . PHE A 1 307 ? -26.075 14.583  14.046  1.000 20.629  0 307 PHE A CD2 1 ? 
ATOM   2429 C CE1 . PHE A 1 307 ? -24.018 13.515  12.555  1.000 20.633  0 307 PHE A CE1 1 ? 
ATOM   2430 C CE2 . PHE A 1 307 ? -24.827 15.191  14.028  1.000 21.134  0 307 PHE A CE2 1 ? 
ATOM   2431 C CZ  . PHE A 1 307 ? -23.808 14.664  13.274  1.000 20.709  0 307 PHE A CZ  1 ? 
ATOM   2432 N N   . GLY A 1 308 ? -30.750 12.224  11.826  1.000 22.031  0 308 GLY A N   1 ? 
ATOM   2433 C CA  . GLY A 1 308 ? -31.921 11.322  11.720  1.000 22.823  0 308 GLY A CA  1 ? 
ATOM   2434 C C   . GLY A 1 308 ? -32.492 10.896  13.073  1.000 23.100  0 308 GLY A C   1 ? 
ATOM   2435 O O   . GLY A 1 308 ? -32.044 11.356  14.113  1.000 23.886  0 308 GLY A O   1 ? 
ATOM   2436 N N   . SER A 1 309 ? -33.477 10.016  13.040  1.000 27.358  0 309 SER A N   1 ? 
ATOM   2437 C CA  . SER A 1 309 ? -34.449 9.768   14.132  1.000 28.569  0 309 SER A CA  1 ? 
ATOM   2438 C C   . SER A 1 309 ? -33.780 8.944   15.235  1.000 27.886  0 309 SER A C   1 ? 
ATOM   2439 O O   . SER A 1 309 ? -34.298 8.891   16.329  1.000 27.077  0 309 SER A O   1 ? 
ATOM   2440 C CB  . SER A 1 309 ? -35.689 9.073   13.576  1.000 31.079  0 309 SER A CB  1 ? 
ATOM   2441 O OG  . SER A 1 309 ? -35.377 7.724   13.219  1.000 32.803  0 309 SER A OG  1 ? 
ATOM   2442 N N   . GLU A 1 310 ? -32.604 8.383   14.988  1.000 28.836  0 310 GLU A N   1 ? 
ATOM   2443 C CA  . GLU A 1 310 ? -31.906 7.642   16.055  1.000 26.553  0 310 GLU A CA  1 ? 
ATOM   2444 C C   . GLU A 1 310 ? -31.116 8.591   16.939  1.000 23.593  0 310 GLU A C   1 ? 
ATOM   2445 O O   . GLU A 1 310 ? -30.657 8.128   18.003  1.000 22.509  0 310 GLU A O   1 ? 
ATOM   2446 C CB  . GLU A 1 310 ? -31.111 6.498   15.452  1.000 30.436  0 310 GLU A CB  1 ? 
ATOM   2447 C CG  . GLU A 1 310 ? -32.024 5.351   15.042  1.000 33.312  0 310 GLU A CG  1 ? 
ATOM   2448 C CD  . GLU A 1 310 ? -31.322 4.017   14.957  1.000 36.442  0 310 GLU A CD  1 ? 
ATOM   2449 O OE1 . GLU A 1 310 ? -30.434 3.873   14.066  1.000 40.826  0 310 GLU A OE1 1 ? 
ATOM   2450 O OE2 . GLU A 1 310 ? -31.611 3.157   15.801  1.000 44.661  0 310 GLU A OE2 1 ? 
ATOM   2451 N N   . PHE A 1 311 ? -31.002 9.871   16.584  1.000 21.586  0 311 PHE A N   1 ? 
ATOM   2452 C CA  . PHE A 1 311 ? -30.385 10.864  17.494  1.000 22.998  0 311 PHE A CA  1 ? 
ATOM   2453 C C   . PHE A 1 311 ? -31.412 11.201  18.562  1.000 26.477  0 311 PHE A C   1 ? 
ATOM   2454 O O   . PHE A 1 311 ? -32.484 11.703  18.234  1.000 25.771  0 311 PHE A O   1 ? 
ATOM   2455 C CB  . PHE A 1 311 ? -29.929 12.160  16.821  1.000 22.507  0 311 PHE A CB  1 ? 
ATOM   2456 C CG  . PHE A 1 311 ? -28.990 12.938  17.706  1.000 21.828  0 311 PHE A CG  1 ? 
ATOM   2457 C CD1 . PHE A 1 311 ? -29.472 13.678  18.772  1.000 22.323  0 311 PHE A CD1 1 ? 
ATOM   2458 C CD2 . PHE A 1 311 ? -27.614 12.825  17.552  1.000 20.452  0 311 PHE A CD2 1 ? 
ATOM   2459 C CE1 . PHE A 1 311 ? -28.613 14.337  19.630  1.000 23.553  0 311 PHE A CE1 1 ? 
ATOM   2460 C CE2 . PHE A 1 311 ? -26.755 13.502  18.401  1.000 20.652  0 311 PHE A CE2 1 ? 
ATOM   2461 C CZ  . PHE A 1 311 ? -27.247 14.251  19.440  1.000 21.077  0 311 PHE A CZ  1 ? 
ATOM   2462 N N   . PRO A 1 312 ? -31.149 10.883  19.850  1.000 25.185  0 312 PRO A N   1 ? 
ATOM   2463 C CA  . PRO A 1 312 ? -32.178 11.022  20.870  1.000 28.624  0 312 PRO A CA  1 ? 
ATOM   2464 C C   . PRO A 1 312 ? -32.553 12.492  21.074  1.000 30.358  0 312 PRO A C   1 ? 
ATOM   2465 O O   . PRO A 1 312 ? -31.654 13.343  21.146  1.000 27.476  0 312 PRO A O   1 ? 
ATOM   2466 C CB  . PRO A 1 312 ? -31.583 10.448  22.167  1.000 29.136  0 312 PRO A CB  1 ? 
ATOM   2467 C CG  . PRO A 1 312 ? -30.131 10.124  21.861  1.000 27.826  0 312 PRO A CG  1 ? 
ATOM   2468 C CD  . PRO A 1 312 ? -29.869 10.439  20.394  1.000 24.935  0 312 PRO A CD  1 ? 
ATOM   2469 N N   . VAL A 1 313 ? -33.851 12.772  21.217  1.000 27.096  0 313 VAL A N   1 ? 
ATOM   2470 C CA  . VAL A 1 313 ? -34.344 14.134  21.577  1.000 28.000  0 313 VAL A CA  1 ? 
ATOM   2471 C C   . VAL A 1 313 ? -35.121 14.067  22.898  1.000 33.445  0 313 VAL A C   1 ? 
ATOM   2472 O O   . VAL A 1 313 ? -36.266 13.629  22.922  1.000 26.695  0 313 VAL A O   1 ? 
ATOM   2473 C CB  . VAL A 1 313 ? -35.189 14.682  20.424  1.000 30.002  0 313 VAL A CB  1 ? 
ATOM   2474 C CG1 . VAL A 1 313 ? -35.622 16.118  20.665  1.000 30.912  0 313 VAL A CG1 1 ? 
ATOM   2475 C CG2 . VAL A 1 313 ? -34.449 14.539  19.088  1.000 28.865  0 313 VAL A CG2 1 ? 
ATOM   2476 N N   . PRO A 1 314 ? -34.515 14.420  24.054  1.000 33.553  0 314 PRO A N   1 ? 
ATOM   2477 C CA  . PRO A 1 314 ? -35.262 14.479  25.316  1.000 36.886  0 314 PRO A CA  1 ? 
ATOM   2478 C C   . PRO A 1 314 ? -36.416 15.496  25.257  1.000 42.124  0 314 PRO A C   1 ? 
ATOM   2479 O O   . PRO A 1 314 ? -36.340 16.488  24.529  1.000 37.316  0 314 PRO A O   1 ? 
ATOM   2480 C CB  . PRO A 1 314 ? -34.220 14.930  26.359  1.000 37.032  0 314 PRO A CB  1 ? 
ATOM   2481 C CG  . PRO A 1 314 ? -32.870 14.600  25.722  1.000 35.776  0 314 PRO A CG  1 ? 
ATOM   2482 C CD  . PRO A 1 314 ? -33.093 14.748  24.229  1.000 35.930  0 314 PRO A CD  1 ? 
ATOM   2483 N N   . GLU A 1 315 ? -37.438 15.271  26.071  1.000 46.444  0 315 GLU A N   1 ? 
ATOM   2484 C CA  . GLU A 1 315 ? -38.660 16.121  26.123  1.000 50.964  0 315 GLU A CA  1 ? 
ATOM   2485 C C   . GLU A 1 315 ? -38.373 17.406  26.920  1.000 48.791  0 315 GLU A C   1 ? 
ATOM   2486 O O   . GLU A 1 315 ? -37.378 17.417  27.682  1.000 42.882  0 315 GLU A O   1 ? 
ATOM   2487 C CB  . GLU A 1 315 ? -39.787 15.302  26.746  1.000 52.004  0 315 GLU A CB  1 ? 
ATOM   2488 C CG  . GLU A 1 315 ? -39.974 13.960  26.078  1.000 52.278  0 315 GLU A CG  1 ? 
ATOM   2489 C CD  . GLU A 1 315 ? -41.179 13.963  25.168  1.000 58.958  0 315 GLU A CD  1 ? 
ATOM   2490 O OE1 . GLU A 1 315 ? -41.170 14.734  24.187  1.000 60.409  0 315 GLU A OE1 1 ? 
ATOM   2491 O OE2 . GLU A 1 315 ? -42.148 13.242  25.482  1.000 73.718  0 315 GLU A OE2 1 ? 
ATOM   2492 N N   . LYS A 1 316 ? -39.221 18.440  26.752  1.000 59.470  0 316 LYS A N   1 ? 
ATOM   2493 C CA  . LYS A 1 316 ? -39.267 19.676  27.598  1.000 64.984  0 316 LYS A CA  1 ? 
ATOM   2494 C C   . LYS A 1 316 ? -38.004 20.497  27.361  1.000 69.135  0 316 LYS A C   1 ? 
ATOM   2495 O O   . LYS A 1 316 ? -38.087 21.667  27.036  1.000 78.012  0 316 LYS A O   1 ? 
ATOM   2496 C CB  . LYS A 1 316 ? -39.368 19.377  29.100  1.000 69.683  0 316 LYS A CB  1 ? 
ATOM   2497 C CG  . LYS A 1 316 ? -40.775 19.104  29.614  1.000 83.484  0 316 LYS A CG  1 ? 
ATOM   2498 C CD  . LYS A 1 316 ? -41.245 17.691  29.357  1.000 87.840  0 316 LYS A CD  1 ? 
ATOM   2499 C CE  . LYS A 1 316 ? -40.496 16.670  30.188  1.000 93.334  0 316 LYS A CE  1 ? 
ATOM   2500 N NZ  . LYS A 1 316 ? -41.125 15.333  30.097  1.000 96.263  0 316 LYS A NZ  1 ? 
HETATM 2501 P P   . PO4 B 2 .   ? -15.171 1.166   18.956  1.000 44.110  0 400 PO4 A P   1 ? 
HETATM 2502 O O1  . PO4 B 2 .   ? -14.981 2.097   17.688  1.000 27.404  0 400 PO4 A O1  1 ? 
HETATM 2503 O O2  . PO4 B 2 .   ? -16.620 1.233   19.445  1.000 40.740  0 400 PO4 A O2  1 ? 
HETATM 2504 O O3  . PO4 B 2 .   ? -14.886 -0.272  18.605  1.000 53.699  0 400 PO4 A O3  1 ? 
HETATM 2505 O O4  . PO4 B 2 .   ? -14.177 1.595   20.046  1.000 46.455  0 400 PO4 A O4  1 ? 
HETATM 2506 O O   . HOH C 3 .   ? -22.419 -13.883 -11.371 1.000 48.336  0 501 HOH A O   1 ? 
HETATM 2507 O O   . HOH C 3 .   ? -20.522 -6.940  -17.268 1.000 33.516  0 502 HOH A O   1 ? 
HETATM 2508 O O   . HOH C 3 .   ? -3.218  -15.367 -3.563  1.000 35.529  0 503 HOH A O   1 ? 
HETATM 2509 O O   . HOH C 3 .   ? -27.893 -9.310  7.262   1.000 39.585  0 504 HOH A O   1 ? 
HETATM 2510 O O   . HOH C 3 .   ? -29.145 -4.952  6.321   1.000 41.971  0 505 HOH A O   1 ? 
HETATM 2511 O O   . HOH C 3 .   ? -21.998 28.280  10.429  1.000 40.576  0 506 HOH A O   1 ? 
HETATM 2512 O O   . HOH C 3 .   ? -8.264  11.186  -8.730  1.000 25.321  0 507 HOH A O   1 ? 
HETATM 2513 O O   . HOH C 3 .   ? -28.845 2.020   13.733  1.000 26.956  0 508 HOH A O   1 ? 
HETATM 2514 O O   . HOH C 3 .   ? 0.919   -1.479  -3.122  1.000 43.168  0 509 HOH A O   1 ? 
HETATM 2515 O O   . HOH C 3 .   ? 1.833   1.918   2.994   1.000 33.113  0 510 HOH A O   1 ? 
HETATM 2516 O O   . HOH C 3 .   ? -26.741 16.255  27.620  1.000 34.342  0 511 HOH A O   1 ? 
HETATM 2517 O O   . HOH C 3 .   ? -26.779 3.810   24.931  1.000 43.725  0 512 HOH A O   1 ? 
HETATM 2518 O O   . HOH C 3 .   ? -33.855 22.989  17.769  1.000 36.070  0 513 HOH A O   1 ? 
HETATM 2519 O O   . HOH C 3 .   ? 0.125   10.073  3.309   1.000 40.113  0 514 HOH A O   1 ? 
HETATM 2520 O O   . HOH C 3 .   ? -34.827 11.418  17.280  1.000 31.293  0 515 HOH A O   1 ? 
HETATM 2521 O O   . HOH C 3 .   ? -5.763  15.616  12.071  1.000 32.557  0 516 HOH A O   1 ? 
HETATM 2522 O O   . HOH C 3 .   ? -8.221  4.502   -4.517  1.000 26.691  0 517 HOH A O   1 ? 
HETATM 2523 O O   . HOH C 3 .   ? 0.253   6.672   -7.972  1.000 30.784  0 518 HOH A O   1 ? 
HETATM 2524 O O   . HOH C 3 .   ? -20.527 16.602  22.790  1.000 21.427  0 519 HOH A O   1 ? 
HETATM 2525 O O   . HOH C 3 .   ? -24.001 15.593  -2.977  1.000 19.984  0 520 HOH A O   1 ? 
HETATM 2526 O O   . HOH C 3 .   ? -7.019  18.344  19.730  1.000 33.204  0 521 HOH A O   1 ? 
HETATM 2527 O O   . HOH C 3 .   ? -8.097  -1.180  -2.913  1.000 36.570  0 522 HOH A O   1 ? 
HETATM 2528 O O   . HOH C 3 .   ? -12.297 -8.243  -22.082 1.000 33.317  0 523 HOH A O   1 ? 
HETATM 2529 O O   . HOH C 3 .   ? 4.212   -14.710 -3.040  1.000 37.951  0 524 HOH A O   1 ? 
HETATM 2530 O O   . HOH C 3 .   ? -18.089 16.430  27.282  1.000 30.388  0 525 HOH A O   1 ? 
HETATM 2531 O O   . HOH C 3 .   ? -33.372 26.253  23.800  1.000 43.836  0 526 HOH A O   1 ? 
HETATM 2532 O O   . HOH C 3 .   ? -22.555 27.257  7.828   1.000 36.459  0 527 HOH A O   1 ? 
HETATM 2533 O O   . HOH C 3 .   ? -16.170 18.035  28.592  1.000 43.071  0 528 HOH A O   1 ? 
HETATM 2534 O O   . HOH C 3 .   ? -22.530 27.765  19.100  1.000 31.727  0 529 HOH A O   1 ? 
HETATM 2535 O O   . HOH C 3 .   ? -32.601 9.665   3.771   1.000 43.824  0 530 HOH A O   1 ? 
HETATM 2536 O O   . HOH C 3 .   ? -14.400 3.888   7.034   1.000 19.892  0 531 HOH A O   1 ? 
HETATM 2537 O O   . HOH C 3 .   ? -5.366  2.031   -2.269  1.000 18.705  0 532 HOH A O   1 ? 
HETATM 2538 O O   . HOH C 3 .   ? -22.917 -13.990 2.046   1.000 41.317  0 533 HOH A O   1 ? 
HETATM 2539 O O   . HOH C 3 .   ? -1.477  7.089   10.975  1.000 29.835  0 534 HOH A O   1 ? 
HETATM 2540 O O   . HOH C 3 .   ? -28.726 23.856  9.979   1.000 23.348  0 535 HOH A O   1 ? 
HETATM 2541 O O   . HOH C 3 .   ? -10.113 21.045  -2.316  1.000 21.509  0 536 HOH A O   1 ? 
HETATM 2542 O O   . HOH C 3 .   ? -21.352 -20.476 0.536   1.000 32.004  0 537 HOH A O   1 ? 
HETATM 2543 O O   . HOH C 3 .   ? -2.985  3.573   17.498  1.000 26.600  0 538 HOH A O   1 ? 
HETATM 2544 O O   . HOH C 3 .   ? -13.420 16.521  -5.881  1.000 18.960  0 539 HOH A O   1 ? 
HETATM 2545 O O   . HOH C 3 .   ? 1.063   -1.359  2.970   1.000 31.912  0 540 HOH A O   1 ? 
HETATM 2546 O O   . HOH C 3 .   ? -12.046 17.665  15.084  1.000 18.081  0 541 HOH A O   1 ? 
HETATM 2547 O O   . HOH C 3 .   ? -30.491 8.296   12.604  1.000 16.786  0 542 HOH A O   1 ? 
HETATM 2548 O O   . HOH C 3 .   ? -20.114 20.690  23.188  1.000 35.245  0 543 HOH A O   1 ? 
HETATM 2549 O O   . HOH C 3 .   ? -7.033  -6.512  6.350   1.000 33.634  0 544 HOH A O   1 ? 
HETATM 2550 O O   . HOH C 3 .   ? -25.996 4.477   8.815   1.000 26.815  0 545 HOH A O   1 ? 
HETATM 2551 O O   . HOH C 3 .   ? -12.182 -6.578  12.495  1.000 22.184  0 546 HOH A O   1 ? 
HETATM 2552 O O   . HOH C 3 .   ? -14.179 28.498  4.861   1.000 41.113  0 547 HOH A O   1 ? 
HETATM 2553 O O   . HOH C 3 .   ? -6.661  2.057   16.351  1.000 31.312  0 548 HOH A O   1 ? 
HETATM 2554 O O   . HOH C 3 .   ? -9.646  21.405  12.684  1.000 37.202  0 549 HOH A O   1 ? 
HETATM 2555 O O   . HOH C 3 .   ? -12.840 20.261  24.204  1.000 35.507  0 550 HOH A O   1 ? 
HETATM 2556 O O   . HOH C 3 .   ? -7.273  18.285  0.299   1.000 36.073  0 551 HOH A O   1 ? 
HETATM 2557 O O   . HOH C 3 .   ? -6.684  -14.405 4.729   1.000 46.032  0 552 HOH A O   1 ? 
HETATM 2558 O O   . HOH C 3 .   ? -12.599 -14.193 -18.275 1.000 35.551  0 553 HOH A O   1 ? 
HETATM 2559 O O   . HOH C 3 .   ? -9.245  2.898   20.949  1.000 27.497  0 554 HOH A O   1 ? 
HETATM 2560 O O   . HOH C 3 .   ? -25.670 -0.702  17.466  1.000 38.309  0 555 HOH A O   1 ? 
HETATM 2561 O O   . HOH C 3 .   ? -19.355 22.709  -7.577  1.000 28.996  0 556 HOH A O   1 ? 
HETATM 2562 O O   . HOH C 3 .   ? -9.525  -3.798  -27.007 1.000 23.178  0 557 HOH A O   1 ? 
HETATM 2563 O O   . HOH C 3 .   ? -17.164 13.979  31.749  1.000 39.480  0 558 HOH A O   1 ? 
HETATM 2564 O O   . HOH C 3 .   ? -10.691 15.217  -8.943  1.000 41.804  0 559 HOH A O   1 ? 
HETATM 2565 O O   . HOH C 3 .   ? -13.395 15.127  -10.415 1.000 43.290  0 560 HOH A O   1 ? 
HETATM 2566 O O   . HOH C 3 .   ? -12.534 28.645  9.284   1.000 49.293  0 561 HOH A O   1 ? 
HETATM 2567 O O   . HOH C 3 .   ? -28.335 26.192  8.259   1.000 28.258  0 562 HOH A O   1 ? 
HETATM 2568 O O   . HOH C 3 .   ? -31.140 11.061  26.119  1.000 35.818  0 563 HOH A O   1 ? 
HETATM 2569 O O   . HOH C 3 .   ? -9.081  1.915   12.890  1.000 24.227  0 564 HOH A O   1 ? 
HETATM 2570 O O   . HOH C 3 .   ? -0.459  -6.913  -8.192  1.000 26.091  0 565 HOH A O   1 ? 
HETATM 2571 O O   . HOH C 3 .   ? -34.850 13.390  12.195  1.000 33.102  0 566 HOH A O   1 ? 
HETATM 2572 O O   . HOH C 3 .   ? -17.501 24.618  19.663  1.000 33.669  0 567 HOH A O   1 ? 
HETATM 2573 O O   . HOH C 3 .   ? -16.345 0.099   -8.497  1.000 29.055  0 568 HOH A O   1 ? 
HETATM 2574 O O   . HOH C 3 .   ? -26.623 15.880  -2.522  1.000 22.960  0 569 HOH A O   1 ? 
HETATM 2575 O O   . HOH C 3 .   ? -9.541  -0.971  3.394   1.000 41.336  0 570 HOH A O   1 ? 
HETATM 2576 O O   . HOH C 3 .   ? -10.928 19.219  13.001  1.000 15.943  0 571 HOH A O   1 ? 
HETATM 2577 O O   . HOH C 3 .   ? -8.600  -5.480  -23.718 1.000 30.761  0 572 HOH A O   1 ? 
HETATM 2578 O O   . HOH C 3 .   ? -15.957 -3.885  5.277   1.000 31.237  0 573 HOH A O   1 ? 
HETATM 2579 O O   . HOH C 3 .   ? -7.354  19.720  11.354  1.000 29.852  0 574 HOH A O   1 ? 
HETATM 2580 O O   . HOH C 3 .   ? -4.571  8.061   -8.776  1.000 33.945  0 575 HOH A O   1 ? 
HETATM 2581 O O   . HOH C 3 .   ? -21.203 5.354   22.647  1.000 22.691  0 576 HOH A O   1 ? 
HETATM 2582 O O   . HOH C 3 .   ? -11.399 -5.090  -8.597  1.000 20.889  0 577 HOH A O   1 ? 
HETATM 2583 O O   . HOH C 3 .   ? -2.806  -2.100  -16.502 1.000 30.035  0 578 HOH A O   1 ? 
HETATM 2584 O O   . HOH C 3 .   ? -7.961  0.667   10.603  1.000 22.799  0 579 HOH A O   1 ? 
HETATM 2585 O O   . HOH C 3 .   ? -6.211  15.385  17.849  1.000 24.469  0 580 HOH A O   1 ? 
HETATM 2586 O O   . HOH C 3 .   ? -25.234 15.925  -11.071 1.000 37.138  0 581 HOH A O   1 ? 
HETATM 2587 O O   . HOH C 3 .   ? -13.972 -4.533  -1.433  1.000 46.866  0 582 HOH A O   1 ? 
HETATM 2588 O O   . HOH C 3 .   ? -16.956 -1.157  13.165  1.000 25.046  0 583 HOH A O   1 ? 
HETATM 2589 O O   . HOH C 3 .   ? -6.545  5.725   15.217  1.000 15.321  0 584 HOH A O   1 ? 
HETATM 2590 O O   . HOH C 3 .   ? -14.396 0.704   -17.522 1.000 30.769  0 585 HOH A O   1 ? 
HETATM 2591 O O   . HOH C 3 .   ? -12.058 -11.718 10.238  1.000 34.436  0 586 HOH A O   1 ? 
HETATM 2592 O O   . HOH C 3 .   ? -6.059  13.951  15.389  1.000 30.001  0 587 HOH A O   1 ? 
HETATM 2593 O O   . HOH C 3 .   ? -22.704 -4.644  16.235  1.000 33.887  0 588 HOH A O   1 ? 
HETATM 2594 O O   . HOH C 3 .   ? -27.063 -14.441 3.878   1.000 44.299  0 589 HOH A O   1 ? 
HETATM 2595 O O   . HOH C 3 .   ? -10.878 -12.135 5.003   1.000 40.095  0 590 HOH A O   1 ? 
HETATM 2596 O O   . HOH C 3 .   ? -2.194  -2.963  0.933   1.000 25.917  0 591 HOH A O   1 ? 
HETATM 2597 O O   . HOH C 3 .   ? -29.387 18.743  -3.434  1.000 30.732  0 592 HOH A O   1 ? 
HETATM 2598 O O   . HOH C 3 .   ? -26.911 18.420  6.608   1.000 16.303  0 593 HOH A O   1 ? 
HETATM 2599 O O   . HOH C 3 .   ? 0.985   3.600   -0.641  1.000 21.681  0 594 HOH A O   1 ? 
HETATM 2600 O O   . HOH C 3 .   ? -5.874  1.428   -7.000  1.000 40.599  0 595 HOH A O   1 ? 
HETATM 2601 O O   . HOH C 3 .   ? -13.494 8.793   23.581  1.000 17.623  0 596 HOH A O   1 ? 
HETATM 2602 O O   . HOH C 3 .   ? -5.990  -3.541  -28.189 1.000 31.458  0 597 HOH A O   1 ? 
HETATM 2603 O O   . HOH C 3 .   ? -6.044  13.329  -6.187  1.000 35.248  0 598 HOH A O   1 ? 
HETATM 2604 O O   . HOH C 3 .   ? -32.112 15.606  2.390   1.000 26.074  0 599 HOH A O   1 ? 
HETATM 2605 O O   . HOH C 3 .   ? -6.562  20.683  0.793   1.000 29.101  0 600 HOH A O   1 ? 
HETATM 2606 O O   . HOH C 3 .   ? -15.393 4.488   19.279  1.000 24.148  0 601 HOH A O   1 ? 
HETATM 2607 O O   . HOH C 3 .   ? -19.807 -11.918 17.197  1.000 52.288  0 602 HOH A O   1 ? 
HETATM 2608 O O   . HOH C 3 .   ? -23.956 -8.156  12.508  1.000 39.405  0 603 HOH A O   1 ? 
HETATM 2609 O O   . HOH C 3 .   ? -2.303  -6.873  -18.080 1.000 35.848  0 604 HOH A O   1 ? 
HETATM 2610 O O   . HOH C 3 .   ? -30.733 21.688  12.270  1.000 35.976  0 605 HOH A O   1 ? 
HETATM 2611 O O   . HOH C 3 .   ? -11.509 2.230   -15.001 1.000 33.169  0 606 HOH A O   1 ? 
HETATM 2612 O O   . HOH C 3 .   ? -28.346 3.158   5.149   1.000 38.333  0 607 HOH A O   1 ? 
HETATM 2613 O O   . HOH C 3 .   ? -21.787 18.464  24.503  1.000 25.358  0 608 HOH A O   1 ? 
HETATM 2614 O O   . HOH C 3 .   ? -24.917 8.110   26.931  1.000 30.431  0 609 HOH A O   1 ? 
HETATM 2615 O O   . HOH C 3 .   ? -10.244 23.523  14.420  1.000 47.261  0 610 HOH A O   1 ? 
HETATM 2616 O O   . HOH C 3 .   ? -6.614  10.403  26.488  1.000 46.622  0 611 HOH A O   1 ? 
HETATM 2617 O O   . HOH C 3 .   ? -3.998  7.964   23.318  1.000 38.595  0 612 HOH A O   1 ? 
HETATM 2618 O O   . HOH C 3 .   ? -20.417 1.080   7.739   1.000 31.047  0 613 HOH A O   1 ? 
HETATM 2619 O O   . HOH C 3 .   ? -15.530 9.746   -5.905  1.000 29.788  0 614 HOH A O   1 ? 
HETATM 2620 O O   . HOH C 3 .   ? -35.693 10.617  20.895  1.000 35.117  0 615 HOH A O   1 ? 
HETATM 2621 O O   . HOH C 3 .   ? -35.108 20.217  27.296  1.000 37.515  0 616 HOH A O   1 ? 
HETATM 2622 O O   . HOH C 3 .   ? -7.706  -9.732  6.760   1.000 32.534  0 617 HOH A O   1 ? 
HETATM 2623 O O   . HOH C 3 .   ? -0.773  1.841   -11.285 1.000 31.301  0 618 HOH A O   1 ? 
HETATM 2624 O O   . HOH C 3 .   ? -9.910  -2.728  13.373  1.000 38.365  0 619 HOH A O   1 ? 
HETATM 2625 O O   . HOH C 3 .   ? -17.235 -1.874  4.182   1.000 35.883  0 620 HOH A O   1 ? 
HETATM 2626 O O   . HOH C 3 .   ? -12.886 -1.742  -4.718  1.000 25.984  0 621 HOH A O   1 ? 
HETATM 2627 O O   . HOH C 3 .   ? -3.963  -18.758 -8.950  1.000 45.696  0 622 HOH A O   1 ? 
HETATM 2628 O O   . HOH C 3 .   ? -15.609 -20.885 -21.258 1.000 47.838  0 623 HOH A O   1 ? 
HETATM 2629 O O   . HOH C 3 .   ? -6.934  22.695  6.603   1.000 29.701  0 624 HOH A O   1 ? 
HETATM 2630 O O   . HOH C 3 .   ? -3.800  9.083   20.749  1.000 22.227  0 625 HOH A O   1 ? 
HETATM 2631 O O   . HOH C 3 .   ? -18.291 10.577  26.319  1.000 23.817  0 626 HOH A O   1 ? 
HETATM 2632 O O   . HOH C 3 .   ? -19.699 4.482   1.228   1.000 37.597  0 627 HOH A O   1 ? 
HETATM 2633 O O   . HOH C 3 .   ? 2.865   -9.129  -14.117 1.000 36.007  0 628 HOH A O   1 ? 
HETATM 2634 O O   . HOH C 3 .   ? -5.423  2.009   21.036  1.000 40.201  0 629 HOH A O   1 ? 
HETATM 2635 O O   . HOH C 3 .   ? -24.192 10.496  -10.055 1.000 50.473  0 630 HOH A O   1 ? 
HETATM 2636 O O   . HOH C 3 .   ? -10.073 -3.099  17.423  1.000 32.040  0 631 HOH A O   1 ? 
HETATM 2637 O O   . HOH C 3 .   ? -9.150  19.041  23.462  1.000 28.356  0 632 HOH A O   1 ? 
HETATM 2638 O O   . HOH C 3 .   ? -22.814 19.204  -12.345 1.000 37.196  0 633 HOH A O   1 ? 
HETATM 2639 O O   . HOH C 3 .   ? -6.289  8.521   24.412  1.000 22.958  0 634 HOH A O   1 ? 
HETATM 2640 O O   . HOH C 3 .   ? -17.112 -12.338 17.225  1.000 35.348  0 635 HOH A O   1 ? 
HETATM 2641 O O   . HOH C 3 .   ? -32.154 21.913  29.244  1.000 37.452  0 636 HOH A O   1 ? 
HETATM 2642 O O   . HOH C 3 .   ? -28.385 13.202  -2.279  1.000 30.896  0 637 HOH A O   1 ? 
HETATM 2643 O O   . HOH C 3 .   ? -28.737 20.805  -0.585  1.000 41.120  0 638 HOH A O   1 ? 
HETATM 2644 O O   . HOH C 3 .   ? -21.622 -7.407  -14.859 1.000 32.023  0 639 HOH A O   1 ? 
HETATM 2645 O O   . HOH C 3 .   ? -0.603  -15.453 -14.477 1.000 44.204  0 640 HOH A O   1 ? 
HETATM 2646 O O   . HOH C 3 .   ? 3.003   -15.718 -4.898  1.000 38.746  0 641 HOH A O   1 ? 
HETATM 2647 O O   . HOH C 3 .   ? -10.349 -0.391  16.771  1.000 20.672  0 642 HOH A O   1 ? 
HETATM 2648 O O   . HOH C 3 .   ? -10.022 0.707   -26.916 1.000 31.264  0 643 HOH A O   1 ? 
HETATM 2649 O O   . HOH C 3 .   ? -16.888 20.184  -10.939 1.000 32.220  0 644 HOH A O   1 ? 
HETATM 2650 O O   . HOH C 3 .   ? -23.994 0.221   6.507   1.000 32.388  0 645 HOH A O   1 ? 
HETATM 2651 O O   . HOH C 3 .   ? -8.732  -20.147 -3.648  1.000 31.870  0 646 HOH A O   1 ? 
HETATM 2652 O O   . HOH C 3 .   ? -12.197 24.271  12.593  1.000 35.815  0 647 HOH A O   1 ? 
HETATM 2653 O O   . HOH C 3 .   ? -22.931 25.290  -1.553  1.000 28.043  0 648 HOH A O   1 ? 
HETATM 2654 O O   . HOH C 3 .   ? -25.923 28.223  14.014  1.000 38.486  0 649 HOH A O   1 ? 
HETATM 2655 O O   . HOH C 3 .   ? -18.913 0.715   -11.516 1.000 42.067  0 650 HOH A O   1 ? 
HETATM 2656 O O   . HOH C 3 .   ? -6.347  -3.502  -23.203 1.000 38.987  0 651 HOH A O   1 ? 
HETATM 2657 O O   . HOH C 3 .   ? -16.153 11.362  27.959  1.000 24.153  0 652 HOH A O   1 ? 
HETATM 2658 O O   . HOH C 3 .   ? -24.156 15.603  27.990  1.000 22.614  0 653 HOH A O   1 ? 
HETATM 2659 O O   . HOH C 3 .   ? -16.632 26.640  13.492  1.000 40.559  0 654 HOH A O   1 ? 
HETATM 2660 O O   . HOH C 3 .   ? -8.948  4.023   14.956  1.000 22.637  0 655 HOH A O   1 ? 
HETATM 2661 O O   . HOH C 3 .   ? -16.542 4.832   21.615  1.000 18.480  0 656 HOH A O   1 ? 
HETATM 2662 O O   . HOH C 3 .   ? -7.446  2.203   18.962  1.000 30.675  0 657 HOH A O   1 ? 
HETATM 2663 O O   . HOH C 3 .   ? -21.802 -0.472  5.163   1.000 30.425  0 658 HOH A O   1 ? 
HETATM 2664 O O   . HOH C 3 .   ? -17.368 10.350  -3.047  1.000 32.276  0 659 HOH A O   1 ? 
HETATM 2665 O O   . HOH C 3 .   ? -16.543 3.807   0.537   1.000 28.805  0 660 HOH A O   1 ? 
HETATM 2666 O O   . HOH C 3 .   ? -6.844  -11.926 -20.636 1.000 23.165  0 661 HOH A O   1 ? 
HETATM 2667 O O   . HOH C 3 .   ? -30.976 22.762  8.587   1.000 36.412  0 662 HOH A O   1 ? 
HETATM 2668 O O   . HOH C 3 .   ? -10.622 -7.037  10.310  1.000 38.266  0 663 HOH A O   1 ? 
HETATM 2669 O O   . HOH C 3 .   ? -21.550 -3.392  -22.156 1.000 46.205  0 664 HOH A O   1 ? 
HETATM 2670 O O   . HOH C 3 .   ? -10.482 -20.685 -5.757  1.000 46.646  0 665 HOH A O   1 ? 
HETATM 2671 O O   . HOH C 3 .   ? -25.500 30.758  9.949   1.000 40.856  0 666 HOH A O   1 ? 
HETATM 2672 O O   . HOH C 3 .   ? -16.250 -15.053 -21.232 1.000 39.682  0 667 HOH A O   1 ? 
HETATM 2673 O O   . HOH C 3 .   ? -22.452 -9.858  -14.860 1.000 42.349  0 668 HOH A O   1 ? 
HETATM 2674 O O   . HOH C 3 .   ? -13.726 5.226   25.469  1.000 32.352  0 669 HOH A O   1 ? 
HETATM 2675 O O   . HOH C 3 .   ? -9.245  0.088   19.188  1.000 30.839  0 670 HOH A O   1 ? 
HETATM 2676 O O   . HOH C 3 .   ? -1.253  10.004  11.398  1.000 41.096  0 671 HOH A O   1 ? 
HETATM 2677 O O   . HOH C 3 .   ? -6.018  16.450  2.047   1.000 35.849  0 672 HOH A O   1 ? 
HETATM 2678 O O   . HOH C 3 .   ? -12.327 4.905   -10.548 1.000 48.458  0 673 HOH A O   1 ? 
HETATM 2679 O O   . HOH C 3 .   ? -7.341  17.343  22.861  1.000 50.277  0 674 HOH A O   1 ? 
HETATM 2680 O O   . HOH C 3 .   ? -33.612 11.152  25.240  1.000 47.881  0 675 HOH A O   1 ? 
HETATM 2681 O O   . HOH C 3 .   ? -4.094  3.211   24.674  1.000 44.408  0 676 HOH A O   1 ? 
HETATM 2682 O O   . HOH C 3 .   ? -11.596 21.364  -9.662  1.000 44.312  0 677 HOH A O   1 ? 
HETATM 2683 O O   . HOH C 3 .   ? -18.961 3.191   4.466   1.000 33.418  0 678 HOH A O   1 ? 
HETATM 2684 O O   . HOH C 3 .   ? 1.047   -0.852  -12.345 1.000 54.526  0 679 HOH A O   1 ? 
HETATM 2685 O O   . HOH C 3 .   ? -7.154  -1.731  11.114  1.000 33.628  0 680 HOH A O   1 ? 
HETATM 2686 O O   . HOH C 3 .   ? -11.179 -7.795  -24.566 1.000 23.882  0 681 HOH A O   1 ? 
HETATM 2687 O O   . HOH C 3 .   ? -22.981 29.549  17.504  1.000 38.741  0 682 HOH A O   1 ? 
HETATM 2688 O O   . HOH C 3 .   ? -23.975 -19.859 0.882   1.000 41.396  0 683 HOH A O   1 ? 
HETATM 2689 O O   . HOH C 3 .   ? -4.525  14.490  19.859  1.000 33.431  0 684 HOH A O   1 ? 
HETATM 2690 O O   . HOH C 3 .   ? 4.325   -15.291 -13.192 1.000 44.849  0 685 HOH A O   1 ? 
HETATM 2691 O O   . HOH C 3 .   ? -17.397 0.995   -20.522 1.000 52.964  0 686 HOH A O   1 ? 
HETATM 2692 O O   . HOH C 3 .   ? -28.946 -13.420 2.987   1.000 43.351  0 687 HOH A O   1 ? 
HETATM 2693 O O   . HOH C 3 .   ? -8.581  0.361   15.031  1.000 30.449  0 688 HOH A O   1 ? 
HETATM 2694 O O   . HOH C 3 .   ? -2.049  11.780  23.803  1.000 44.191  0 689 HOH A O   1 ? 
HETATM 2695 O O   . HOH C 3 .   ? -7.427  1.993   -0.263  1.000 41.852  0 690 HOH A O   1 ? 
HETATM 2696 O O   . HOH C 3 .   ? -4.123  -10.659 -22.488 1.000 34.809  0 691 HOH A O   1 ? 
HETATM 2697 O O   . HOH C 3 .   ? -19.166 15.291  29.412  1.000 36.801  0 692 HOH A O   1 ? 
HETATM 2698 O O   . HOH C 3 .   ? -22.297 29.318  21.453  1.000 40.546  0 693 HOH A O   1 ? 
HETATM 2699 O O   . HOH C 3 .   ? -20.242 18.398  26.622  1.000 32.944  0 694 HOH A O   1 ? 
HETATM 2700 O O   . HOH C 3 .   ? -7.263  1.276   -4.889  1.000 44.877  0 695 HOH A O   1 ? 
HETATM 2701 O O   . HOH C 3 .   ? -7.184  16.821  27.960  1.000 42.643  0 696 HOH A O   1 ? 
HETATM 2702 O O   . HOH C 3 .   ? -27.056 -5.534  10.448  1.000 46.708  0 697 HOH A O   1 ? 
HETATM 2703 O O   . HOH C 3 .   ? -2.455  13.224  19.043  1.000 47.181  0 698 HOH A O   1 ? 
HETATM 2704 O O   . HOH C 3 .   ? -9.411  3.207   -2.091  1.000 45.415  0 699 HOH A O   1 ? 
# 
