data_8YSM
# 
_entry.id   8YSM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YSM         pdb_00008ysm 10.2210/pdb8ysm/pdb 
WWPDB D_1300046305 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YSM 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chyeah6599@nchu.edu.tw 
_pdbx_contact_author.name_first         Yeh 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7740-0446 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, Y.-C.' 1 ? 
'Yang, C.-S.' 2 ? 
'Hou, M.-H.'  3 ? 
'Chen, Y.'    4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            295 
_citation.language                  ? 
_citation.page_first                139534 
_citation.page_last                 139534 
_citation.title                     
'Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.139534 
_citation.pdbx_database_id_PubMed   39761885 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, C.S.'  1 ? 
primary 'Shie, M.Y.'  2 ? 
primary 'Huang, S.W.' 3 ? 
primary 'Wang, Y.C.'  4 ? 
primary 'Hou, M.H.'   5 ? 
primary 'Chen, C.J.'  6 ? 
primary 'Chen, Y.'    7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleotidyltransferase     39217.918 1   ? ? ? ? 
2 non-polymer syn "CYTIDINE-5'-TRIPHOSPHATE" 483.156   1   ? ? ? ? 
3 non-polymer syn 'MANGANESE (II) ION'       54.938    2   ? ? ? ? 
4 non-polymer syn 'PHOSPHATE ION'            94.971    1   ? ? ? ? 
5 water       nat water                      18.015    378 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "CYTIDINE-5'-TRIPHOSPHATE" CTP 
3 'MANGANESE (II) ION'       MN  
4 'PHOSPHATE ION'            PO4 
5 water                      HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PRO n 
1 4   VAL n 
1 5   GLN n 
1 6   LYS n 
1 7   GLN n 
1 8   PHE n 
1 9   ARG n 
1 10  GLU n 
1 11  PHE n 
1 12  HIS n 
1 13  ASP n 
1 14  ARG n 
1 15  ILE n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLN n 
1 20  TYR n 
1 21  ASP n 
1 22  GLU n 
1 23  ASN n 
1 24  GLN n 
1 25  THR n 
1 26  LEU n 
1 27  ARG n 
1 28  ASP n 
1 29  GLU n 
1 30  ARG n 
1 31  ASP n 
1 32  ALA n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  ALA n 
1 37  VAL n 
1 38  ARG n 
1 39  GLU n 
1 40  GLY n 
1 41  LEU n 
1 42  LYS n 
1 43  LYS n 
1 44  VAL n 
1 45  PHE n 
1 46  ALA n 
1 47  ASP n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  ALA n 
1 52  ALA n 
1 53  PRO n 
1 54  THR n 
1 55  PHE n 
1 56  THR n 
1 57  PRO n 
1 58  PHE n 
1 59  ASN n 
1 60  GLN n 
1 61  GLY n 
1 62  SER n 
1 63  TYR n 
1 64  ALA n 
1 65  MET n 
1 66  ASN n 
1 67  THR n 
1 68  GLY n 
1 69  VAL n 
1 70  LYS n 
1 71  PRO n 
1 72  LEU n 
1 73  GLU n 
1 74  GLY n 
1 75  GLY n 
1 76  GLU n 
1 77  TYR n 
1 78  ASP n 
1 79  ILE n 
1 80  ASP n 
1 81  VAL n 
1 82  GLY n 
1 83  ILE n 
1 84  ILE n 
1 85  LEU n 
1 86  ASN n 
1 87  ILE n 
1 88  ALA n 
1 89  LYS n 
1 90  ASP n 
1 91  ASP n 
1 92  HIS n 
1 93  ASP n 
1 94  PRO n 
1 95  VAL n 
1 96  GLU n 
1 97  VAL n 
1 98  LYS n 
1 99  LYS n 
1 100 TRP n 
1 101 ILE n 
1 102 ARG n 
1 103 ASP n 
1 104 ALA n 
1 105 LEU n 
1 106 LYS n 
1 107 ASP n 
1 108 TYR n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 ALA n 
1 113 GLU n 
1 114 ILE n 
1 115 ARG n 
1 116 ARG n 
1 117 SER n 
1 118 CYS n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 PHE n 
1 123 LYS n 
1 124 PRO n 
1 125 GLY n 
1 126 TYR n 
1 127 HIS n 
1 128 VAL n 
1 129 ASP n 
1 130 LEU n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 ALA n 
1 135 ASP n 
1 136 PRO n 
1 137 GLU n 
1 138 LEU n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 LEU n 
1 144 CYS n 
1 145 ILE n 
1 146 ALA n 
1 147 LYS n 
1 148 GLY n 
1 149 LYS n 
1 150 GLU n 
1 151 ASN n 
1 152 SER n 
1 153 GLY n 
1 154 ASP n 
1 155 GLU n 
1 156 HIS n 
1 157 ARG n 
1 158 LEU n 
1 159 TRP n 
1 160 GLN n 
1 161 ILE n 
1 162 SER n 
1 163 ASP n 
1 164 PRO n 
1 165 GLN n 
1 166 GLY n 
1 167 PHE n 
1 168 GLN n 
1 169 ASP n 
1 170 ARG n 
1 171 ILE n 
1 172 ALA n 
1 173 SER n 
1 174 LYS n 
1 175 LEU n 
1 176 SER n 
1 177 GLY n 
1 178 ASP n 
1 179 ASP n 
1 180 ALA n 
1 181 ALA n 
1 182 GLN n 
1 183 PHE n 
1 184 ARG n 
1 185 ARG n 
1 186 CYS n 
1 187 ILE n 
1 188 ARG n 
1 189 TYR n 
1 190 LEU n 
1 191 LYS n 
1 192 ARG n 
1 193 TRP n 
1 194 ARG n 
1 195 ASP n 
1 196 PHE n 
1 197 ARG n 
1 198 PHE n 
1 199 SER n 
1 200 SER n 
1 201 ASP n 
1 202 GLY n 
1 203 ASN n 
1 204 ALA n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 LEU n 
1 212 THR n 
1 213 ALA n 
1 214 ALA n 
1 215 ALA n 
1 216 TYR n 
1 217 TRP n 
1 218 TRP n 
1 219 PHE n 
1 220 GLN n 
1 221 VAL n 
1 222 SER n 
1 223 LYS n 
1 224 ARG n 
1 225 THR n 
1 226 ASP n 
1 227 PRO n 
1 228 VAL n 
1 229 SER n 
1 230 GLN n 
1 231 ASN n 
1 232 VAL n 
1 233 THR n 
1 234 TYR n 
1 235 ASP n 
1 236 ASP n 
1 237 ARG n 
1 238 ASP n 
1 239 ALA n 
1 240 LEU n 
1 241 GLU n 
1 242 GLN n 
1 243 PHE n 
1 244 VAL n 
1 245 GLN n 
1 246 THR n 
1 247 MET n 
1 248 LEU n 
1 249 ASP n 
1 250 ASN n 
1 251 PHE n 
1 252 HIS n 
1 253 ASP n 
1 254 THR n 
1 255 TRP n 
1 256 ASP n 
1 257 SER n 
1 258 LYS n 
1 259 ASP n 
1 260 GLN n 
1 261 ARG n 
1 262 SER n 
1 263 TYR n 
1 264 PRO n 
1 265 ARG n 
1 266 LEU n 
1 267 THR n 
1 268 VAL n 
1 269 GLU n 
1 270 LEU n 
1 271 PRO n 
1 272 VAL n 
1 273 GLN n 
1 274 PRO n 
1 275 TYR n 
1 276 ASN n 
1 277 ASP n 
1 278 VAL n 
1 279 PHE n 
1 280 GLU n 
1 281 LYS n 
1 282 MET n 
1 283 THR n 
1 284 GLY n 
1 285 MET n 
1 286 GLN n 
1 287 MET n 
1 288 GLU n 
1 289 SER n 
1 290 PHE n 
1 291 LYS n 
1 292 SER n 
1 293 LYS n 
1 294 LEU n 
1 295 GLN n 
1 296 ALA n 
1 297 LEU n 
1 298 LEU n 
1 299 ASN n 
1 300 ALA n 
1 301 LEU n 
1 302 LYS n 
1 303 THR n 
1 304 ALA n 
1 305 LYS n 
1 306 SER n 
1 307 ARG n 
1 308 LEU n 
1 309 GLU n 
1 310 LEU n 
1 311 HIS n 
1 312 ASP n 
1 313 ALA n 
1 314 CYS n 
1 315 LYS n 
1 316 ALA n 
1 317 LEU n 
1 318 ALA n 
1 319 ASP n 
1 320 HIS n 
1 321 PHE n 
1 322 GLY n 
1 323 SER n 
1 324 GLU n 
1 325 PHE n 
1 326 PRO n 
1 327 VAL n 
1 328 PRO n 
1 329 GLU n 
1 330 LYS n 
1 331 ASP n 
1 332 LYS n 
1 333 SER n 
1 334 ALA n 
1 335 VAL n 
1 336 HIS n 
1 337 THR n 
1 338 ALA n 
1 339 PRO n 
1 340 ALA n 
1 341 ILE n 
1 342 VAL n 
1 343 GLY n 
1 344 SER n 
1 345 GLY n 
1 346 SER n 
1 347 SER n 
1 348 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   348 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 DVJ83_15700 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Deinococcus wulumuqiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     980427 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                    ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                   ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                 ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'            ? 'C4 H7 N O4'       133.103 
CTP non-polymer         . "CYTIDINE-5'-TRIPHOSPHATE" ? 'C9 H16 N3 O14 P3' 483.156 
CYS 'L-peptide linking' y CYSTEINE                   ? 'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking' y GLUTAMINE                  ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'            ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                    ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking' y HISTIDINE                  ? 'C6 H10 N3 O2 1'   156.162 
HOH non-polymer         . WATER                      ? 'H2 O'             18.015  
ILE 'L-peptide linking' y ISOLEUCINE                 ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                    ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                     ? 'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE                 ? 'C5 H11 N O2 S'    149.211 
MN  non-polymer         . 'MANGANESE (II) ION'       ? 'Mn 2'             54.938  
PHE 'L-peptide linking' y PHENYLALANINE              ? 'C9 H11 N O2'      165.189 
PO4 non-polymer         . 'PHOSPHATE ION'            ? 'O4 P -3'          94.971  
PRO 'L-peptide linking' y PROLINE                    ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                     ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                  ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                 ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                   ? 'C9 H11 N O3'      181.189 
VAL 'L-peptide linking' y VALINE                     ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PRO 3   3   3   PRO PRO A . n 
A 1 4   VAL 4   4   4   VAL VAL A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ALA 18  18  18  ALA ALA A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ASP 28  28  28  ASP ASP A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  ARG 30  30  30  ARG ARG A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  THR 35  35  35  THR THR A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  PRO 53  53  53  PRO PRO A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  TYR 63  63  63  TYR TYR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  MET 65  65  65  MET MET A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 CYS 118 118 118 CYS CYS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 HIS 127 127 127 HIS HIS A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 GLY 141 141 141 GLY GLY A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 ASP 154 154 154 ASP ASP A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 HIS 156 156 156 HIS HIS A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 PRO 164 164 164 PRO PRO A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLN 168 168 168 GLN GLN A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 CYS 186 186 186 CYS CYS A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 VAL 221 221 221 VAL VAL A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLN 230 230 230 GLN GLN A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 TYR 234 234 234 TYR TYR A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 ARG 237 237 237 ARG ARG A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 PHE 243 243 243 PHE PHE A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 MET 247 247 247 MET MET A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 ASP 249 249 249 ASP ASP A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 HIS 252 252 252 HIS HIS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 TRP 255 255 255 TRP TRP A . n 
A 1 256 ASP 256 256 256 ASP ASP A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 PRO 264 264 264 PRO PRO A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 GLU 269 269 269 GLU GLU A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 ASP 277 277 277 ASP ASP A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 LYS 281 281 281 LYS LYS A . n 
A 1 282 MET 282 282 282 MET MET A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 SER 289 289 289 SER SER A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 GLN 295 295 295 GLN GLN A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 LEU 297 297 297 LEU LEU A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 SER 306 306 306 SER SER A . n 
A 1 307 ARG 307 307 307 ARG ARG A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 GLU 309 309 309 GLU GLU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 HIS 311 311 311 HIS HIS A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 ALA 318 318 318 ALA ALA A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 320 HIS HIS A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 GLU 324 324 324 GLU GLU A . n 
A 1 325 PHE 325 325 325 PHE PHE A . n 
A 1 326 PRO 326 326 326 PRO PRO A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 PRO 328 328 328 PRO PRO A . n 
A 1 329 GLU 329 329 329 GLU GLU A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 ASP 331 331 ?   ?   ?   A . n 
A 1 332 LYS 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 ALA 334 334 ?   ?   ?   A . n 
A 1 335 VAL 335 335 ?   ?   ?   A . n 
A 1 336 HIS 336 336 ?   ?   ?   A . n 
A 1 337 THR 337 337 ?   ?   ?   A . n 
A 1 338 ALA 338 338 ?   ?   ?   A . n 
A 1 339 PRO 339 339 ?   ?   ?   A . n 
A 1 340 ALA 340 340 ?   ?   ?   A . n 
A 1 341 ILE 341 341 ?   ?   ?   A . n 
A 1 342 VAL 342 342 ?   ?   ?   A . n 
A 1 343 GLY 343 343 ?   ?   ?   A . n 
A 1 344 SER 344 344 ?   ?   ?   A . n 
A 1 345 GLY 345 345 ?   ?   ?   A . n 
A 1 346 SER 346 346 ?   ?   ?   A . n 
A 1 347 SER 347 347 ?   ?   ?   A . n 
A 1 348 GLY 348 348 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        CTP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   CTP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CTP 1   401 403 CTP CTP A . 
C 3 MN  1   402 405 MN  MN  A . 
D 3 MN  1   403 406 MN  MN  A . 
E 4 PO4 1   404 407 PO4 PO4 A . 
F 5 HOH 1   501 847 HOH HOH A . 
F 5 HOH 2   502 754 HOH HOH A . 
F 5 HOH 3   503 773 HOH HOH A . 
F 5 HOH 4   504 846 HOH HOH A . 
F 5 HOH 5   505 818 HOH HOH A . 
F 5 HOH 6   506 675 HOH HOH A . 
F 5 HOH 7   507 837 HOH HOH A . 
F 5 HOH 8   508 640 HOH HOH A . 
F 5 HOH 9   509 826 HOH HOH A . 
F 5 HOH 10  510 831 HOH HOH A . 
F 5 HOH 11  511 736 HOH HOH A . 
F 5 HOH 12  512 711 HOH HOH A . 
F 5 HOH 13  513 805 HOH HOH A . 
F 5 HOH 14  514 871 HOH HOH A . 
F 5 HOH 15  515 761 HOH HOH A . 
F 5 HOH 16  516 718 HOH HOH A . 
F 5 HOH 17  517 799 HOH HOH A . 
F 5 HOH 18  518 651 HOH HOH A . 
F 5 HOH 19  519 507 HOH HOH A . 
F 5 HOH 20  520 594 HOH HOH A . 
F 5 HOH 21  521 690 HOH HOH A . 
F 5 HOH 22  522 674 HOH HOH A . 
F 5 HOH 23  523 827 HOH HOH A . 
F 5 HOH 24  524 608 HOH HOH A . 
F 5 HOH 25  525 596 HOH HOH A . 
F 5 HOH 26  526 770 HOH HOH A . 
F 5 HOH 27  527 556 HOH HOH A . 
F 5 HOH 28  528 712 HOH HOH A . 
F 5 HOH 29  529 558 HOH HOH A . 
F 5 HOH 30  530 509 HOH HOH A . 
F 5 HOH 31  531 541 HOH HOH A . 
F 5 HOH 32  532 731 HOH HOH A . 
F 5 HOH 33  533 782 HOH HOH A . 
F 5 HOH 34  534 791 HOH HOH A . 
F 5 HOH 35  535 588 HOH HOH A . 
F 5 HOH 36  536 804 HOH HOH A . 
F 5 HOH 37  537 545 HOH HOH A . 
F 5 HOH 38  538 648 HOH HOH A . 
F 5 HOH 39  539 622 HOH HOH A . 
F 5 HOH 40  540 611 HOH HOH A . 
F 5 HOH 41  541 689 HOH HOH A . 
F 5 HOH 42  542 623 HOH HOH A . 
F 5 HOH 43  543 522 HOH HOH A . 
F 5 HOH 44  544 540 HOH HOH A . 
F 5 HOH 45  545 532 HOH HOH A . 
F 5 HOH 46  546 803 HOH HOH A . 
F 5 HOH 47  547 832 HOH HOH A . 
F 5 HOH 48  548 775 HOH HOH A . 
F 5 HOH 49  549 538 HOH HOH A . 
F 5 HOH 50  550 647 HOH HOH A . 
F 5 HOH 51  551 668 HOH HOH A . 
F 5 HOH 52  552 629 HOH HOH A . 
F 5 HOH 53  553 508 HOH HOH A . 
F 5 HOH 54  554 734 HOH HOH A . 
F 5 HOH 55  555 526 HOH HOH A . 
F 5 HOH 56  556 515 HOH HOH A . 
F 5 HOH 57  557 543 HOH HOH A . 
F 5 HOH 58  558 643 HOH HOH A . 
F 5 HOH 59  559 614 HOH HOH A . 
F 5 HOH 60  560 724 HOH HOH A . 
F 5 HOH 61  561 748 HOH HOH A . 
F 5 HOH 62  562 868 HOH HOH A . 
F 5 HOH 63  563 816 HOH HOH A . 
F 5 HOH 64  564 525 HOH HOH A . 
F 5 HOH 65  565 535 HOH HOH A . 
F 5 HOH 66  566 701 HOH HOH A . 
F 5 HOH 67  567 795 HOH HOH A . 
F 5 HOH 68  568 821 HOH HOH A . 
F 5 HOH 69  569 518 HOH HOH A . 
F 5 HOH 70  570 524 HOH HOH A . 
F 5 HOH 71  571 817 HOH HOH A . 
F 5 HOH 72  572 755 HOH HOH A . 
F 5 HOH 73  573 833 HOH HOH A . 
F 5 HOH 74  574 703 HOH HOH A . 
F 5 HOH 75  575 562 HOH HOH A . 
F 5 HOH 76  576 579 HOH HOH A . 
F 5 HOH 77  577 659 HOH HOH A . 
F 5 HOH 78  578 778 HOH HOH A . 
F 5 HOH 79  579 530 HOH HOH A . 
F 5 HOH 80  580 529 HOH HOH A . 
F 5 HOH 81  581 829 HOH HOH A . 
F 5 HOH 82  582 855 HOH HOH A . 
F 5 HOH 83  583 679 HOH HOH A . 
F 5 HOH 84  584 762 HOH HOH A . 
F 5 HOH 85  585 779 HOH HOH A . 
F 5 HOH 86  586 613 HOH HOH A . 
F 5 HOH 87  587 742 HOH HOH A . 
F 5 HOH 88  588 523 HOH HOH A . 
F 5 HOH 89  589 582 HOH HOH A . 
F 5 HOH 90  590 533 HOH HOH A . 
F 5 HOH 91  591 774 HOH HOH A . 
F 5 HOH 92  592 586 HOH HOH A . 
F 5 HOH 93  593 624 HOH HOH A . 
F 5 HOH 94  594 654 HOH HOH A . 
F 5 HOH 95  595 844 HOH HOH A . 
F 5 HOH 96  596 657 HOH HOH A . 
F 5 HOH 97  597 807 HOH HOH A . 
F 5 HOH 98  598 500 HOH HOH A . 
F 5 HOH 99  599 559 HOH HOH A . 
F 5 HOH 100 600 751 HOH HOH A . 
F 5 HOH 101 601 591 HOH HOH A . 
F 5 HOH 102 602 602 HOH HOH A . 
F 5 HOH 103 603 549 HOH HOH A . 
F 5 HOH 104 604 600 HOH HOH A . 
F 5 HOH 105 605 581 HOH HOH A . 
F 5 HOH 106 606 745 HOH HOH A . 
F 5 HOH 107 607 544 HOH HOH A . 
F 5 HOH 108 608 510 HOH HOH A . 
F 5 HOH 109 609 819 HOH HOH A . 
F 5 HOH 110 610 634 HOH HOH A . 
F 5 HOH 111 611 505 HOH HOH A . 
F 5 HOH 112 612 735 HOH HOH A . 
F 5 HOH 113 613 684 HOH HOH A . 
F 5 HOH 114 614 758 HOH HOH A . 
F 5 HOH 115 615 822 HOH HOH A . 
F 5 HOH 116 616 776 HOH HOH A . 
F 5 HOH 117 617 753 HOH HOH A . 
F 5 HOH 118 618 552 HOH HOH A . 
F 5 HOH 119 619 557 HOH HOH A . 
F 5 HOH 120 620 517 HOH HOH A . 
F 5 HOH 121 621 563 HOH HOH A . 
F 5 HOH 122 622 649 HOH HOH A . 
F 5 HOH 123 623 700 HOH HOH A . 
F 5 HOH 124 624 519 HOH HOH A . 
F 5 HOH 125 625 875 HOH HOH A . 
F 5 HOH 126 626 555 HOH HOH A . 
F 5 HOH 127 627 628 HOH HOH A . 
F 5 HOH 128 628 834 HOH HOH A . 
F 5 HOH 129 629 645 HOH HOH A . 
F 5 HOH 130 630 618 HOH HOH A . 
F 5 HOH 131 631 693 HOH HOH A . 
F 5 HOH 132 632 536 HOH HOH A . 
F 5 HOH 133 633 553 HOH HOH A . 
F 5 HOH 134 634 655 HOH HOH A . 
F 5 HOH 135 635 595 HOH HOH A . 
F 5 HOH 136 636 511 HOH HOH A . 
F 5 HOH 137 637 585 HOH HOH A . 
F 5 HOH 138 638 504 HOH HOH A . 
F 5 HOH 139 639 661 HOH HOH A . 
F 5 HOH 140 640 597 HOH HOH A . 
F 5 HOH 141 641 756 HOH HOH A . 
F 5 HOH 142 642 560 HOH HOH A . 
F 5 HOH 143 643 603 HOH HOH A . 
F 5 HOH 144 644 605 HOH HOH A . 
F 5 HOH 145 645 630 HOH HOH A . 
F 5 HOH 146 646 671 HOH HOH A . 
F 5 HOH 147 647 550 HOH HOH A . 
F 5 HOH 148 648 662 HOH HOH A . 
F 5 HOH 149 649 769 HOH HOH A . 
F 5 HOH 150 650 726 HOH HOH A . 
F 5 HOH 151 651 575 HOH HOH A . 
F 5 HOH 152 652 612 HOH HOH A . 
F 5 HOH 153 653 521 HOH HOH A . 
F 5 HOH 154 654 709 HOH HOH A . 
F 5 HOH 155 655 561 HOH HOH A . 
F 5 HOH 156 656 743 HOH HOH A . 
F 5 HOH 157 657 752 HOH HOH A . 
F 5 HOH 158 658 548 HOH HOH A . 
F 5 HOH 159 659 506 HOH HOH A . 
F 5 HOH 160 660 593 HOH HOH A . 
F 5 HOH 161 661 587 HOH HOH A . 
F 5 HOH 162 662 820 HOH HOH A . 
F 5 HOH 163 663 520 HOH HOH A . 
F 5 HOH 164 664 708 HOH HOH A . 
F 5 HOH 165 665 574 HOH HOH A . 
F 5 HOH 166 666 606 HOH HOH A . 
F 5 HOH 167 667 815 HOH HOH A . 
F 5 HOH 168 668 571 HOH HOH A . 
F 5 HOH 169 669 569 HOH HOH A . 
F 5 HOH 170 670 713 HOH HOH A . 
F 5 HOH 171 671 672 HOH HOH A . 
F 5 HOH 172 672 825 HOH HOH A . 
F 5 HOH 173 673 567 HOH HOH A . 
F 5 HOH 174 674 727 HOH HOH A . 
F 5 HOH 175 675 767 HOH HOH A . 
F 5 HOH 176 676 615 HOH HOH A . 
F 5 HOH 177 677 641 HOH HOH A . 
F 5 HOH 178 678 638 HOH HOH A . 
F 5 HOH 179 679 652 HOH HOH A . 
F 5 HOH 180 680 719 HOH HOH A . 
F 5 HOH 181 681 707 HOH HOH A . 
F 5 HOH 182 682 766 HOH HOH A . 
F 5 HOH 183 683 565 HOH HOH A . 
F 5 HOH 184 684 502 HOH HOH A . 
F 5 HOH 185 685 531 HOH HOH A . 
F 5 HOH 186 686 583 HOH HOH A . 
F 5 HOH 187 687 806 HOH HOH A . 
F 5 HOH 188 688 653 HOH HOH A . 
F 5 HOH 189 689 527 HOH HOH A . 
F 5 HOH 190 690 749 HOH HOH A . 
F 5 HOH 191 691 729 HOH HOH A . 
F 5 HOH 192 692 680 HOH HOH A . 
F 5 HOH 193 693 539 HOH HOH A . 
F 5 HOH 194 694 554 HOH HOH A . 
F 5 HOH 195 695 682 HOH HOH A . 
F 5 HOH 196 696 658 HOH HOH A . 
F 5 HOH 197 697 723 HOH HOH A . 
F 5 HOH 198 698 590 HOH HOH A . 
F 5 HOH 199 699 516 HOH HOH A . 
F 5 HOH 200 700 564 HOH HOH A . 
F 5 HOH 201 701 625 HOH HOH A . 
F 5 HOH 202 702 673 HOH HOH A . 
F 5 HOH 203 703 669 HOH HOH A . 
F 5 HOH 204 704 853 HOH HOH A . 
F 5 HOH 205 705 621 HOH HOH A . 
F 5 HOH 206 706 665 HOH HOH A . 
F 5 HOH 207 707 580 HOH HOH A . 
F 5 HOH 208 708 760 HOH HOH A . 
F 5 HOH 209 709 644 HOH HOH A . 
F 5 HOH 210 710 771 HOH HOH A . 
F 5 HOH 211 711 573 HOH HOH A . 
F 5 HOH 212 712 620 HOH HOH A . 
F 5 HOH 213 713 566 HOH HOH A . 
F 5 HOH 214 714 764 HOH HOH A . 
F 5 HOH 215 715 738 HOH HOH A . 
F 5 HOH 216 716 598 HOH HOH A . 
F 5 HOH 217 717 794 HOH HOH A . 
F 5 HOH 218 718 840 HOH HOH A . 
F 5 HOH 219 719 720 HOH HOH A . 
F 5 HOH 220 720 792 HOH HOH A . 
F 5 HOH 221 721 578 HOH HOH A . 
F 5 HOH 222 722 604 HOH HOH A . 
F 5 HOH 223 723 551 HOH HOH A . 
F 5 HOH 224 724 704 HOH HOH A . 
F 5 HOH 225 725 873 HOH HOH A . 
F 5 HOH 226 726 627 HOH HOH A . 
F 5 HOH 227 727 637 HOH HOH A . 
F 5 HOH 228 728 513 HOH HOH A . 
F 5 HOH 229 729 725 HOH HOH A . 
F 5 HOH 230 730 512 HOH HOH A . 
F 5 HOH 231 731 534 HOH HOH A . 
F 5 HOH 232 732 728 HOH HOH A . 
F 5 HOH 233 733 633 HOH HOH A . 
F 5 HOH 234 734 721 HOH HOH A . 
F 5 HOH 235 735 616 HOH HOH A . 
F 5 HOH 236 736 542 HOH HOH A . 
F 5 HOH 237 737 537 HOH HOH A . 
F 5 HOH 238 738 646 HOH HOH A . 
F 5 HOH 239 739 503 HOH HOH A . 
F 5 HOH 240 740 685 HOH HOH A . 
F 5 HOH 241 741 639 HOH HOH A . 
F 5 HOH 242 742 572 HOH HOH A . 
F 5 HOH 243 743 601 HOH HOH A . 
F 5 HOH 244 744 568 HOH HOH A . 
F 5 HOH 245 745 577 HOH HOH A . 
F 5 HOH 246 746 861 HOH HOH A . 
F 5 HOH 247 747 610 HOH HOH A . 
F 5 HOH 248 748 570 HOH HOH A . 
F 5 HOH 249 749 528 HOH HOH A . 
F 5 HOH 250 750 546 HOH HOH A . 
F 5 HOH 251 751 845 HOH HOH A . 
F 5 HOH 252 752 617 HOH HOH A . 
F 5 HOH 253 753 739 HOH HOH A . 
F 5 HOH 254 754 694 HOH HOH A . 
F 5 HOH 255 755 750 HOH HOH A . 
F 5 HOH 256 756 783 HOH HOH A . 
F 5 HOH 257 757 710 HOH HOH A . 
F 5 HOH 258 758 737 HOH HOH A . 
F 5 HOH 259 759 609 HOH HOH A . 
F 5 HOH 260 760 514 HOH HOH A . 
F 5 HOH 261 761 869 HOH HOH A . 
F 5 HOH 262 762 589 HOH HOH A . 
F 5 HOH 263 763 798 HOH HOH A . 
F 5 HOH 264 764 547 HOH HOH A . 
F 5 HOH 265 765 501 HOH HOH A . 
F 5 HOH 266 766 699 HOH HOH A . 
F 5 HOH 267 767 687 HOH HOH A . 
F 5 HOH 268 768 841 HOH HOH A . 
F 5 HOH 269 769 730 HOH HOH A . 
F 5 HOH 270 770 696 HOH HOH A . 
F 5 HOH 271 771 667 HOH HOH A . 
F 5 HOH 272 772 867 HOH HOH A . 
F 5 HOH 273 773 576 HOH HOH A . 
F 5 HOH 274 774 786 HOH HOH A . 
F 5 HOH 275 775 823 HOH HOH A . 
F 5 HOH 276 776 688 HOH HOH A . 
F 5 HOH 277 777 705 HOH HOH A . 
F 5 HOH 278 778 850 HOH HOH A . 
F 5 HOH 279 779 626 HOH HOH A . 
F 5 HOH 280 780 789 HOH HOH A . 
F 5 HOH 281 781 635 HOH HOH A . 
F 5 HOH 282 782 732 HOH HOH A . 
F 5 HOH 283 783 636 HOH HOH A . 
F 5 HOH 284 784 660 HOH HOH A . 
F 5 HOH 285 785 681 HOH HOH A . 
F 5 HOH 286 786 808 HOH HOH A . 
F 5 HOH 287 787 677 HOH HOH A . 
F 5 HOH 288 788 848 HOH HOH A . 
F 5 HOH 289 789 835 HOH HOH A . 
F 5 HOH 290 790 851 HOH HOH A . 
F 5 HOH 291 791 741 HOH HOH A . 
F 5 HOH 292 792 740 HOH HOH A . 
F 5 HOH 293 793 733 HOH HOH A . 
F 5 HOH 294 794 666 HOH HOH A . 
F 5 HOH 295 795 777 HOH HOH A . 
F 5 HOH 296 796 746 HOH HOH A . 
F 5 HOH 297 797 859 HOH HOH A . 
F 5 HOH 298 798 870 HOH HOH A . 
F 5 HOH 299 799 813 HOH HOH A . 
F 5 HOH 300 800 785 HOH HOH A . 
F 5 HOH 301 801 810 HOH HOH A . 
F 5 HOH 302 802 632 HOH HOH A . 
F 5 HOH 303 803 781 HOH HOH A . 
F 5 HOH 304 804 858 HOH HOH A . 
F 5 HOH 305 805 849 HOH HOH A . 
F 5 HOH 306 806 692 HOH HOH A . 
F 5 HOH 307 807 864 HOH HOH A . 
F 5 HOH 308 808 865 HOH HOH A . 
F 5 HOH 309 809 830 HOH HOH A . 
F 5 HOH 310 810 802 HOH HOH A . 
F 5 HOH 311 811 744 HOH HOH A . 
F 5 HOH 312 812 857 HOH HOH A . 
F 5 HOH 313 813 874 HOH HOH A . 
F 5 HOH 314 814 691 HOH HOH A . 
F 5 HOH 315 815 796 HOH HOH A . 
F 5 HOH 316 816 797 HOH HOH A . 
F 5 HOH 317 817 757 HOH HOH A . 
F 5 HOH 318 818 592 HOH HOH A . 
F 5 HOH 319 819 812 HOH HOH A . 
F 5 HOH 320 820 856 HOH HOH A . 
F 5 HOH 321 821 584 HOH HOH A . 
F 5 HOH 322 822 642 HOH HOH A . 
F 5 HOH 323 823 790 HOH HOH A . 
F 5 HOH 324 824 619 HOH HOH A . 
F 5 HOH 325 825 650 HOH HOH A . 
F 5 HOH 326 826 800 HOH HOH A . 
F 5 HOH 327 827 678 HOH HOH A . 
F 5 HOH 328 828 854 HOH HOH A . 
F 5 HOH 329 829 698 HOH HOH A . 
F 5 HOH 330 830 676 HOH HOH A . 
F 5 HOH 331 831 765 HOH HOH A . 
F 5 HOH 332 832 697 HOH HOH A . 
F 5 HOH 333 833 683 HOH HOH A . 
F 5 HOH 334 834 686 HOH HOH A . 
F 5 HOH 335 835 824 HOH HOH A . 
F 5 HOH 336 836 811 HOH HOH A . 
F 5 HOH 337 837 787 HOH HOH A . 
F 5 HOH 338 838 793 HOH HOH A . 
F 5 HOH 339 839 702 HOH HOH A . 
F 5 HOH 340 840 838 HOH HOH A . 
F 5 HOH 341 841 747 HOH HOH A . 
F 5 HOH 342 842 780 HOH HOH A . 
F 5 HOH 343 843 788 HOH HOH A . 
F 5 HOH 344 844 839 HOH HOH A . 
F 5 HOH 345 845 706 HOH HOH A . 
F 5 HOH 346 846 862 HOH HOH A . 
F 5 HOH 347 847 866 HOH HOH A . 
F 5 HOH 348 848 631 HOH HOH A . 
F 5 HOH 349 849 872 HOH HOH A . 
F 5 HOH 350 850 670 HOH HOH A . 
F 5 HOH 351 851 843 HOH HOH A . 
F 5 HOH 352 852 768 HOH HOH A . 
F 5 HOH 353 853 784 HOH HOH A . 
F 5 HOH 354 854 695 HOH HOH A . 
F 5 HOH 355 855 656 HOH HOH A . 
F 5 HOH 356 856 842 HOH HOH A . 
F 5 HOH 357 857 722 HOH HOH A . 
F 5 HOH 358 858 763 HOH HOH A . 
F 5 HOH 359 859 599 HOH HOH A . 
F 5 HOH 360 860 852 HOH HOH A . 
F 5 HOH 361 861 715 HOH HOH A . 
F 5 HOH 362 862 607 HOH HOH A . 
F 5 HOH 363 863 716 HOH HOH A . 
F 5 HOH 364 864 664 HOH HOH A . 
F 5 HOH 365 865 828 HOH HOH A . 
F 5 HOH 366 866 717 HOH HOH A . 
F 5 HOH 367 867 809 HOH HOH A . 
F 5 HOH 368 868 759 HOH HOH A . 
F 5 HOH 369 869 714 HOH HOH A . 
F 5 HOH 370 870 814 HOH HOH A . 
F 5 HOH 371 871 836 HOH HOH A . 
F 5 HOH 372 872 863 HOH HOH A . 
F 5 HOH 373 873 860 HOH HOH A . 
F 5 HOH 374 874 663 HOH HOH A . 
F 5 HOH 375 875 801 HOH HOH A . 
F 5 HOH 376 876 877 HOH HOH A . 
F 5 HOH 377 877 772 HOH HOH A . 
F 5 HOH 378 878 876 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0267 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? Blu-Ice  ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
# 
_cell.angle_alpha                  105.450 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   103.349 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  99.327 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YSM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.401 
_cell.length_a_esd                 ? 
_cell.length_b                     46.765 
_cell.length_b_esd                 ? 
_cell.length_c                     64.182 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        1 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YSM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YSM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.47 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.15 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M BIS-TRIS propane pH 9.0, 
30% w/v Polyethylene glycol 6,000.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-06-20 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97626 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 07A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97626 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 07A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YSM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.50 
_reflns.d_resolution_low                               30.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     57942 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          40.400 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.044 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.50 
_reflns_shell.d_res_low                                     1.55 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5722 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.978 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.015 
_refine.aniso_B[1][2]                            -0.033 
_refine.aniso_B[1][3]                            0.042 
_refine.aniso_B[2][2]                            -0.021 
_refine.aniso_B[2][3]                            -0.152 
_refine.aniso_B[3][3]                            0.102 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.780 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.961 
_refine.correlation_coeff_Fo_to_Fc_free          0.955 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YSM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.500 
_refine.ls_d_res_low                             23.508 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     57636 
_refine.ls_number_reflns_R_free                  2791 
_refine.ls_number_reflns_R_work                  54845 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.001 
_refine.ls_percent_reflns_R_free                 4.842 
_refine.ls_R_factor_all                          0.174 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.1927 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1734 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.072 
_refine.pdbx_overall_ESU_R_Free                  0.070 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             1.154 
_refine.overall_SU_ML                            0.044 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2647 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         36 
_refine_hist.number_atoms_solvent             378 
_refine_hist.number_atoms_total               3061 
_refine_hist.d_res_high                       1.500 
_refine_hist.d_res_low                        23.508 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.014  0.013  2742 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2523 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.445  1.651  3713 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.408  1.593  5811 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.528  5.000  329  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 32.480 22.134 164  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 13.074 15.000 464  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 13.974 15.000 22   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.082  0.200  342  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.012  0.020  3120 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  663  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.214  0.200  539  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.188  0.200  2350 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.174  0.200  1356 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.080  0.200  1298 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.166  0.200  216  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.185  0.200  12   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.290  0.200  30   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.171  0.200  28   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 0.041  0.200  1    ? r_xyhbond_nbd_other            ? ? 
'X-RAY DIFFRACTION' ? 2.142  1.837  1319 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.142  1.835  1318 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 3.211  2.752  1647 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.210  2.755  1648 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 2.880  2.138  1423 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.864  2.143  1408 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.453  3.083  2066 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.432  3.082  2061 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 5.975  21.930 3193 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.799  21.398 3103 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.500 1.539  . . 199 3742 88.4823 . . . . 0.225 . . . . . . . . . . . 0.248 
'X-RAY DIFFRACTION' 1.539 1.581  . . 193 3902 95.2769 . . . . 0.209 . . . . . . . . . . . 0.246 
'X-RAY DIFFRACTION' 1.581 1.627  . . 174 3884 96.6190 . . . . 0.190 . . . . . . . . . . . 0.220 
'X-RAY DIFFRACTION' 1.627 1.677  . . 210 3754 96.4712 . . . . 0.180 . . . . . . . . . . . 0.211 
'X-RAY DIFFRACTION' 1.677 1.732  . . 173 3583 95.6699 . . . . 0.184 . . . . . . . . . . . 0.216 
'X-RAY DIFFRACTION' 1.732 1.792  . . 186 3471 95.4083 . . . . 0.183 . . . . . . . . . . . 0.215 
'X-RAY DIFFRACTION' 1.792 1.860  . . 178 3458 97.3233 . . . . 0.176 . . . . . . . . . . . 0.209 
'X-RAY DIFFRACTION' 1.860 1.935  . . 204 3202 97.7893 . . . . 0.177 . . . . . . . . . . . 0.183 
'X-RAY DIFFRACTION' 1.935 2.021  . . 140 3179 97.3599 . . . . 0.181 . . . . . . . . . . . 0.225 
'X-RAY DIFFRACTION' 2.021 2.119  . . 145 3063 97.7751 . . . . 0.182 . . . . . . . . . . . 0.200 
'X-RAY DIFFRACTION' 2.119 2.233  . . 147 2872 97.2616 . . . . 0.165 . . . . . . . . . . . 0.191 
'X-RAY DIFFRACTION' 2.233 2.368  . . 144 2700 97.1975 . . . . 0.156 . . . . . . . . . . . 0.179 
'X-RAY DIFFRACTION' 2.368 2.530  . . 144 2474 94.4444 . . . . 0.157 . . . . . . . . . . . 0.180 
'X-RAY DIFFRACTION' 2.530 2.731  . . 106 2305 94.5861 . . . . 0.161 . . . . . . . . . . . 0.196 
'X-RAY DIFFRACTION' 2.731 2.989  . . 103 2227 98.6870 . . . . 0.163 . . . . . . . . . . . 0.204 
'X-RAY DIFFRACTION' 2.989 3.338  . . 111 1987 98.5439 . . . . 0.169 . . . . . . . . . . . 0.181 
'X-RAY DIFFRACTION' 3.338 3.846  . . 93  1761 98.1472 . . . . 0.164 . . . . . . . . . . . 0.167 
'X-RAY DIFFRACTION' 3.846 4.692  . . 67  1454 95.6604 . . . . 0.158 . . . . . . . . . . . 0.144 
'X-RAY DIFFRACTION' 4.692 6.555  . . 56  1170 97.9233 . . . . 0.187 . . . . . . . . . . . 0.187 
'X-RAY DIFFRACTION' 6.555 23.508 . . 18  657  95.2045 . . . . 0.198 . . . . . . . . . . . 0.239 
# 
_struct.entry_id                     8YSM 
_struct.title                        'Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with CTP Mn' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YSM 
_struct_keywords.text            'CD-NTase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A345ILN6_9DEIO 
_struct_ref.pdbx_db_accession          A0A345ILN6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YSM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 348 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A345ILN6 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  348 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       348 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 210   ? 
1 MORE         -7    ? 
1 'SSA (A^2)'  16120 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 4   ? LYS A 16  ? VAL A 4   LYS A 16  1 ? 13 
HELX_P HELX_P2  AA2 GLN A 19  ? GLU A 22  ? GLN A 19  GLU A 22  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 23  ? ASP A 47  ? ASN A 23  ASP A 47  1 ? 25 
HELX_P HELX_P4  AA4 GLY A 61  ? ASN A 66  ? GLY A 61  ASN A 66  1 ? 6  
HELX_P HELX_P5  AA5 ALA A 88  ? HIS A 92  ? ALA A 88  HIS A 92  5 ? 5  
HELX_P HELX_P6  AA6 ASP A 93  ? LEU A 105 ? ASP A 93  LEU A 105 1 ? 13 
HELX_P HELX_P7  AA7 PRO A 136 ? SER A 139 ? PRO A 136 SER A 139 5 ? 4  
HELX_P HELX_P8  AA8 GLY A 153 ? ARG A 157 ? GLY A 153 ARG A 157 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 163 ? LYS A 174 ? ASP A 163 LYS A 174 1 ? 12 
HELX_P HELX_P10 AB1 SER A 176 ? PHE A 198 ? SER A 176 PHE A 198 1 ? 23 
HELX_P HELX_P11 AB2 ASP A 201 ? ALA A 205 ? ASP A 201 ALA A 205 5 ? 5  
HELX_P HELX_P12 AB3 LEU A 207 ? PHE A 219 ? LEU A 207 PHE A 219 1 ? 13 
HELX_P HELX_P13 AB4 ASP A 235 ? ASN A 250 ? ASP A 235 ASN A 250 1 ? 16 
HELX_P HELX_P14 AB5 THR A 283 ? ARG A 307 ? THR A 283 ARG A 307 1 ? 25 
HELX_P HELX_P15 AB6 GLU A 309 ? GLY A 322 ? GLU A 309 GLY A 322 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A ASP 78  OD1 ? ? ? 1_555 C MN  . MN ? ? A ASP 78  A MN  402 1_555 ? ? ? ? ? ? ? 2.252 ? ? 
metalc2  metalc ? ? A ASP 78  OD2 ? ? ? 1_555 C MN  . MN ? ? A ASP 78  A MN  402 1_555 ? ? ? ? ? ? ? 2.456 ? ? 
metalc3  metalc ? ? A ASP 78  OD2 ? ? ? 1_555 D MN  . MN ? ? A ASP 78  A MN  403 1_555 ? ? ? ? ? ? ? 2.043 ? ? 
metalc4  metalc ? ? A ASP 80  OD2 ? ? ? 1_555 C MN  . MN ? ? A ASP 80  A MN  402 1_555 ? ? ? ? ? ? ? 2.131 ? ? 
metalc5  metalc ? ? A ASP 80  OD1 ? ? ? 1_555 D MN  . MN ? ? A ASP 80  A MN  403 1_555 ? ? ? ? ? ? ? 2.180 ? ? 
metalc6  metalc ? ? A ASP 129 OD2 ? ? ? 1_555 C MN  . MN ? ? A ASP 129 A MN  402 1_555 ? ? ? ? ? ? ? 2.063 ? ? 
metalc7  metalc ? ? B CTP .   O2A ? ? ? 1_555 D MN  . MN ? ? A CTP 401 A MN  403 1_555 ? ? ? ? ? ? ? 2.284 ? ? 
metalc8  metalc ? ? B CTP .   O2B ? ? ? 1_555 D MN  . MN ? ? A CTP 401 A MN  403 1_555 ? ? ? ? ? ? ? 2.087 ? ? 
metalc9  metalc ? ? B CTP .   O1G ? ? ? 1_555 D MN  . MN ? ? A CTP 401 A MN  403 1_555 ? ? ? ? ? ? ? 2.173 ? ? 
metalc10 metalc ? ? C MN  .   MN  ? ? ? 1_555 F HOH . O  ? ? A MN  402 A HOH 613 1_555 ? ? ? ? ? ? ? 2.189 ? ? 
metalc11 metalc ? ? C MN  .   MN  ? ? ? 1_555 F HOH . O  ? ? A MN  402 A HOH 716 1_555 ? ? ? ? ? ? ? 2.197 ? ? 
metalc12 metalc ? ? D MN  .   MN  ? ? ? 1_555 F HOH . O  ? ? A MN  403 A HOH 530 1_555 ? ? ? ? ? ? ? 2.244 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OD1 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 55.2  ? 
2  OD1 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 94.5  ? 
3  OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 89.2  ? 
4  OD1 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 OD2 ? A ASP 129 ? A ASP 129 ? 1_555 86.9  ? 
5  OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 OD2 ? A ASP 129 ? A ASP 129 ? 1_555 139.8 ? 
6  OD2 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 OD2 ? A ASP 129 ? A ASP 129 ? 1_555 108.3 ? 
7  OD1 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 613 ? 1_555 173.8 ? 
8  OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 613 ? 1_555 124.1 ? 
9  OD2 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 613 ? 1_555 79.3  ? 
10 OD2 ? A ASP 129 ? A ASP 129 ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 613 ? 1_555 95.1  ? 
11 OD1 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 716 ? 1_555 86.9  ? 
12 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 716 ? 1_555 79.9  ? 
13 OD2 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 716 ? 1_555 165.7 ? 
14 OD2 ? A ASP 129 ? A ASP 129 ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 716 ? 1_555 86.0  ? 
15 O   ? F HOH .   ? A HOH 613 ? 1_555 MN ? C MN . ? A MN 402 ? 1_555 O   ? F HOH .   ? A HOH 716 ? 1_555 99.1  ? 
16 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 95.5  ? 
17 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O2A ? B CTP .   ? A CTP 401 ? 1_555 87.4  ? 
18 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O2A ? B CTP .   ? A CTP 401 ? 1_555 93.8  ? 
19 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O2B ? B CTP .   ? A CTP 401 ? 1_555 168.8 ? 
20 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O2B ? B CTP .   ? A CTP 401 ? 1_555 88.6  ? 
21 O2A ? B CTP .   ? A CTP 401 ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O2B ? B CTP .   ? A CTP 401 ? 1_555 82.0  ? 
22 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O1G ? B CTP .   ? A CTP 401 ? 1_555 88.6  ? 
23 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O1G ? B CTP .   ? A CTP 401 ? 1_555 175.2 ? 
24 O2A ? B CTP .   ? A CTP 401 ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O1G ? B CTP .   ? A CTP 401 ? 1_555 89.1  ? 
25 O2B ? B CTP .   ? A CTP 401 ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O1G ? B CTP .   ? A CTP 401 ? 1_555 87.9  ? 
26 OD2 ? A ASP 78  ? A ASP 78  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O   ? F HOH .   ? A HOH 530 ? 1_555 99.1  ? 
27 OD1 ? A ASP 80  ? A ASP 80  ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O   ? F HOH .   ? A HOH 530 ? 1_555 81.9  ? 
28 O2A ? B CTP .   ? A CTP 401 ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O   ? F HOH .   ? A HOH 530 ? 1_555 172.5 ? 
29 O2B ? B CTP .   ? A CTP 401 ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O   ? F HOH .   ? A HOH 530 ? 1_555 91.8  ? 
30 O1G ? B CTP .   ? A CTP 401 ? 1_555 MN ? D MN . ? A MN 403 ? 1_555 O   ? F HOH .   ? A HOH 530 ? 1_555 94.9  ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           273 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            273 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    274 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     274 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       4.65 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? ASN A 59  ? PHE A 55  ASN A 59  
AA1 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA1 3 TYR A 126 ? ALA A 134 ? TYR A 126 ALA A 134 
AA1 4 VAL A 119 ? LYS A 123 ? VAL A 119 LYS A 123 
AA1 5 ALA A 112 ? ILE A 114 ? ALA A 112 ILE A 114 
AA2 1 CYS A 144 ? LYS A 147 ? CYS A 144 LYS A 147 
AA2 2 LEU A 158 ? ILE A 161 ? LEU A 158 ILE A 161 
AA3 1 LYS A 223 ? THR A 225 ? LYS A 223 THR A 225 
AA3 2 VAL A 232 ? TYR A 234 ? VAL A 232 TYR A 234 
AA4 1 PHE A 251 ? ASP A 256 ? PHE A 251 ASP A 256 
AA4 2 ARG A 261 ? LEU A 266 ? ARG A 261 LEU A 266 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 58  ? N PHE A 58  O GLY A 82  ? O GLY A 82  
AA1 2 3 N LEU A 85  ? N LEU A 85  O TYR A 133 ? O TYR A 133 
AA1 3 4 O LEU A 130 ? O LEU A 130 N VAL A 119 ? N VAL A 119 
AA1 4 5 O THR A 120 ? O THR A 120 N GLU A 113 ? N GLU A 113 
AA2 1 2 N LYS A 147 ? N LYS A 147 O LEU A 158 ? O LEU A 158 
AA3 1 2 N ARG A 224 ? N ARG A 224 O THR A 233 ? O THR A 233 
AA4 1 2 N ASP A 256 ? N ASP A 256 O ARG A 261 ? O ARG A 261 
# 
_pdbx_entry_details.entry_id                   8YSM 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_1             241 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OE2 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_2             241 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.185 
_pdbx_validate_rmsd_bond.bond_target_value         1.252 
_pdbx_validate_rmsd_bond.bond_deviation            -0.067 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.011 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 GLN A 230 ? ? 54.83 18.66  
2 1 LEU A 308 ? ? 73.72 -52.23 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 877 ? 6.08 . 
2 1 O ? A HOH 878 ? 6.48 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ASP 331 ? A ASP 331 
2  1 Y 1 A LYS 332 ? A LYS 332 
3  1 Y 1 A SER 333 ? A SER 333 
4  1 Y 1 A ALA 334 ? A ALA 334 
5  1 Y 1 A VAL 335 ? A VAL 335 
6  1 Y 1 A HIS 336 ? A HIS 336 
7  1 Y 1 A THR 337 ? A THR 337 
8  1 Y 1 A ALA 338 ? A ALA 338 
9  1 Y 1 A PRO 339 ? A PRO 339 
10 1 Y 1 A ALA 340 ? A ALA 340 
11 1 Y 1 A ILE 341 ? A ILE 341 
12 1 Y 1 A VAL 342 ? A VAL 342 
13 1 Y 1 A GLY 343 ? A GLY 343 
14 1 Y 1 A SER 344 ? A SER 344 
15 1 Y 1 A GLY 345 ? A GLY 345 
16 1 Y 1 A SER 346 ? A SER 346 
17 1 Y 1 A SER 347 ? A SER 347 
18 1 Y 1 A GLY 348 ? A GLY 348 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CTP N1     N  N N 74  
CTP C2     C  N N 75  
CTP N3     N  N N 76  
CTP C4     C  N N 77  
CTP C5     C  N N 78  
CTP C6     C  N N 79  
CTP O2     O  N N 80  
CTP N4     N  N N 81  
CTP "C1'"  C  N R 82  
CTP "C2'"  C  N R 83  
CTP "O2'"  O  N N 84  
CTP "C3'"  C  N S 85  
CTP "C4'"  C  N R 86  
CTP "O4'"  O  N N 87  
CTP "O3'"  O  N N 88  
CTP "C5'"  C  N N 89  
CTP "O5'"  O  N N 90  
CTP PA     P  N S 91  
CTP O1A    O  N N 92  
CTP O2A    O  N N 93  
CTP O3A    O  N N 94  
CTP PB     P  N R 95  
CTP O1B    O  N N 96  
CTP O2B    O  N N 97  
CTP O3B    O  N N 98  
CTP PG     P  N N 99  
CTP O1G    O  N N 100 
CTP O2G    O  N N 101 
CTP O3G    O  N N 102 
CTP H5     H  N N 103 
CTP H6     H  N N 104 
CTP HN41   H  N N 105 
CTP HN42   H  N N 106 
CTP "H1'"  H  N N 107 
CTP "H2'"  H  N N 108 
CTP "HO2'" H  N N 109 
CTP "H3'"  H  N N 110 
CTP "H4'"  H  N N 111 
CTP "HO3'" H  N N 112 
CTP "H5'1" H  N N 113 
CTP "H5'2" H  N N 114 
CTP HOA2   H  N N 115 
CTP HOB2   H  N N 116 
CTP HOG2   H  N N 117 
CTP HOG3   H  N N 118 
CYS N      N  N N 119 
CYS CA     C  N R 120 
CYS C      C  N N 121 
CYS O      O  N N 122 
CYS CB     C  N N 123 
CYS SG     S  N N 124 
CYS OXT    O  N N 125 
CYS H      H  N N 126 
CYS H2     H  N N 127 
CYS HA     H  N N 128 
CYS HB2    H  N N 129 
CYS HB3    H  N N 130 
CYS HG     H  N N 131 
CYS HXT    H  N N 132 
GLN N      N  N N 133 
GLN CA     C  N S 134 
GLN C      C  N N 135 
GLN O      O  N N 136 
GLN CB     C  N N 137 
GLN CG     C  N N 138 
GLN CD     C  N N 139 
GLN OE1    O  N N 140 
GLN NE2    N  N N 141 
GLN OXT    O  N N 142 
GLN H      H  N N 143 
GLN H2     H  N N 144 
GLN HA     H  N N 145 
GLN HB2    H  N N 146 
GLN HB3    H  N N 147 
GLN HG2    H  N N 148 
GLN HG3    H  N N 149 
GLN HE21   H  N N 150 
GLN HE22   H  N N 151 
GLN HXT    H  N N 152 
GLU N      N  N N 153 
GLU CA     C  N S 154 
GLU C      C  N N 155 
GLU O      O  N N 156 
GLU CB     C  N N 157 
GLU CG     C  N N 158 
GLU CD     C  N N 159 
GLU OE1    O  N N 160 
GLU OE2    O  N N 161 
GLU OXT    O  N N 162 
GLU H      H  N N 163 
GLU H2     H  N N 164 
GLU HA     H  N N 165 
GLU HB2    H  N N 166 
GLU HB3    H  N N 167 
GLU HG2    H  N N 168 
GLU HG3    H  N N 169 
GLU HE2    H  N N 170 
GLU HXT    H  N N 171 
GLY N      N  N N 172 
GLY CA     C  N N 173 
GLY C      C  N N 174 
GLY O      O  N N 175 
GLY OXT    O  N N 176 
GLY H      H  N N 177 
GLY H2     H  N N 178 
GLY HA2    H  N N 179 
GLY HA3    H  N N 180 
GLY HXT    H  N N 181 
HIS N      N  N N 182 
HIS CA     C  N S 183 
HIS C      C  N N 184 
HIS O      O  N N 185 
HIS CB     C  N N 186 
HIS CG     C  Y N 187 
HIS ND1    N  Y N 188 
HIS CD2    C  Y N 189 
HIS CE1    C  Y N 190 
HIS NE2    N  Y N 191 
HIS OXT    O  N N 192 
HIS H      H  N N 193 
HIS H2     H  N N 194 
HIS HA     H  N N 195 
HIS HB2    H  N N 196 
HIS HB3    H  N N 197 
HIS HD1    H  N N 198 
HIS HD2    H  N N 199 
HIS HE1    H  N N 200 
HIS HE2    H  N N 201 
HIS HXT    H  N N 202 
HOH O      O  N N 203 
HOH H1     H  N N 204 
HOH H2     H  N N 205 
ILE N      N  N N 206 
ILE CA     C  N S 207 
ILE C      C  N N 208 
ILE O      O  N N 209 
ILE CB     C  N S 210 
ILE CG1    C  N N 211 
ILE CG2    C  N N 212 
ILE CD1    C  N N 213 
ILE OXT    O  N N 214 
ILE H      H  N N 215 
ILE H2     H  N N 216 
ILE HA     H  N N 217 
ILE HB     H  N N 218 
ILE HG12   H  N N 219 
ILE HG13   H  N N 220 
ILE HG21   H  N N 221 
ILE HG22   H  N N 222 
ILE HG23   H  N N 223 
ILE HD11   H  N N 224 
ILE HD12   H  N N 225 
ILE HD13   H  N N 226 
ILE HXT    H  N N 227 
LEU N      N  N N 228 
LEU CA     C  N S 229 
LEU C      C  N N 230 
LEU O      O  N N 231 
LEU CB     C  N N 232 
LEU CG     C  N N 233 
LEU CD1    C  N N 234 
LEU CD2    C  N N 235 
LEU OXT    O  N N 236 
LEU H      H  N N 237 
LEU H2     H  N N 238 
LEU HA     H  N N 239 
LEU HB2    H  N N 240 
LEU HB3    H  N N 241 
LEU HG     H  N N 242 
LEU HD11   H  N N 243 
LEU HD12   H  N N 244 
LEU HD13   H  N N 245 
LEU HD21   H  N N 246 
LEU HD22   H  N N 247 
LEU HD23   H  N N 248 
LEU HXT    H  N N 249 
LYS N      N  N N 250 
LYS CA     C  N S 251 
LYS C      C  N N 252 
LYS O      O  N N 253 
LYS CB     C  N N 254 
LYS CG     C  N N 255 
LYS CD     C  N N 256 
LYS CE     C  N N 257 
LYS NZ     N  N N 258 
LYS OXT    O  N N 259 
LYS H      H  N N 260 
LYS H2     H  N N 261 
LYS HA     H  N N 262 
LYS HB2    H  N N 263 
LYS HB3    H  N N 264 
LYS HG2    H  N N 265 
LYS HG3    H  N N 266 
LYS HD2    H  N N 267 
LYS HD3    H  N N 268 
LYS HE2    H  N N 269 
LYS HE3    H  N N 270 
LYS HZ1    H  N N 271 
LYS HZ2    H  N N 272 
LYS HZ3    H  N N 273 
LYS HXT    H  N N 274 
MET N      N  N N 275 
MET CA     C  N S 276 
MET C      C  N N 277 
MET O      O  N N 278 
MET CB     C  N N 279 
MET CG     C  N N 280 
MET SD     S  N N 281 
MET CE     C  N N 282 
MET OXT    O  N N 283 
MET H      H  N N 284 
MET H2     H  N N 285 
MET HA     H  N N 286 
MET HB2    H  N N 287 
MET HB3    H  N N 288 
MET HG2    H  N N 289 
MET HG3    H  N N 290 
MET HE1    H  N N 291 
MET HE2    H  N N 292 
MET HE3    H  N N 293 
MET HXT    H  N N 294 
MN  MN     MN N N 295 
PHE N      N  N N 296 
PHE CA     C  N S 297 
PHE C      C  N N 298 
PHE O      O  N N 299 
PHE CB     C  N N 300 
PHE CG     C  Y N 301 
PHE CD1    C  Y N 302 
PHE CD2    C  Y N 303 
PHE CE1    C  Y N 304 
PHE CE2    C  Y N 305 
PHE CZ     C  Y N 306 
PHE OXT    O  N N 307 
PHE H      H  N N 308 
PHE H2     H  N N 309 
PHE HA     H  N N 310 
PHE HB2    H  N N 311 
PHE HB3    H  N N 312 
PHE HD1    H  N N 313 
PHE HD2    H  N N 314 
PHE HE1    H  N N 315 
PHE HE2    H  N N 316 
PHE HZ     H  N N 317 
PHE HXT    H  N N 318 
PO4 P      P  N N 319 
PO4 O1     O  N N 320 
PO4 O2     O  N N 321 
PO4 O3     O  N N 322 
PO4 O4     O  N N 323 
PRO N      N  N N 324 
PRO CA     C  N S 325 
PRO C      C  N N 326 
PRO O      O  N N 327 
PRO CB     C  N N 328 
PRO CG     C  N N 329 
PRO CD     C  N N 330 
PRO OXT    O  N N 331 
PRO H      H  N N 332 
PRO HA     H  N N 333 
PRO HB2    H  N N 334 
PRO HB3    H  N N 335 
PRO HG2    H  N N 336 
PRO HG3    H  N N 337 
PRO HD2    H  N N 338 
PRO HD3    H  N N 339 
PRO HXT    H  N N 340 
SER N      N  N N 341 
SER CA     C  N S 342 
SER C      C  N N 343 
SER O      O  N N 344 
SER CB     C  N N 345 
SER OG     O  N N 346 
SER OXT    O  N N 347 
SER H      H  N N 348 
SER H2     H  N N 349 
SER HA     H  N N 350 
SER HB2    H  N N 351 
SER HB3    H  N N 352 
SER HG     H  N N 353 
SER HXT    H  N N 354 
THR N      N  N N 355 
THR CA     C  N S 356 
THR C      C  N N 357 
THR O      O  N N 358 
THR CB     C  N R 359 
THR OG1    O  N N 360 
THR CG2    C  N N 361 
THR OXT    O  N N 362 
THR H      H  N N 363 
THR H2     H  N N 364 
THR HA     H  N N 365 
THR HB     H  N N 366 
THR HG1    H  N N 367 
THR HG21   H  N N 368 
THR HG22   H  N N 369 
THR HG23   H  N N 370 
THR HXT    H  N N 371 
TRP N      N  N N 372 
TRP CA     C  N S 373 
TRP C      C  N N 374 
TRP O      O  N N 375 
TRP CB     C  N N 376 
TRP CG     C  Y N 377 
TRP CD1    C  Y N 378 
TRP CD2    C  Y N 379 
TRP NE1    N  Y N 380 
TRP CE2    C  Y N 381 
TRP CE3    C  Y N 382 
TRP CZ2    C  Y N 383 
TRP CZ3    C  Y N 384 
TRP CH2    C  Y N 385 
TRP OXT    O  N N 386 
TRP H      H  N N 387 
TRP H2     H  N N 388 
TRP HA     H  N N 389 
TRP HB2    H  N N 390 
TRP HB3    H  N N 391 
TRP HD1    H  N N 392 
TRP HE1    H  N N 393 
TRP HE3    H  N N 394 
TRP HZ2    H  N N 395 
TRP HZ3    H  N N 396 
TRP HH2    H  N N 397 
TRP HXT    H  N N 398 
TYR N      N  N N 399 
TYR CA     C  N S 400 
TYR C      C  N N 401 
TYR O      O  N N 402 
TYR CB     C  N N 403 
TYR CG     C  Y N 404 
TYR CD1    C  Y N 405 
TYR CD2    C  Y N 406 
TYR CE1    C  Y N 407 
TYR CE2    C  Y N 408 
TYR CZ     C  Y N 409 
TYR OH     O  N N 410 
TYR OXT    O  N N 411 
TYR H      H  N N 412 
TYR H2     H  N N 413 
TYR HA     H  N N 414 
TYR HB2    H  N N 415 
TYR HB3    H  N N 416 
TYR HD1    H  N N 417 
TYR HD2    H  N N 418 
TYR HE1    H  N N 419 
TYR HE2    H  N N 420 
TYR HH     H  N N 421 
TYR HXT    H  N N 422 
VAL N      N  N N 423 
VAL CA     C  N S 424 
VAL C      C  N N 425 
VAL O      O  N N 426 
VAL CB     C  N N 427 
VAL CG1    C  N N 428 
VAL CG2    C  N N 429 
VAL OXT    O  N N 430 
VAL H      H  N N 431 
VAL H2     H  N N 432 
VAL HA     H  N N 433 
VAL HB     H  N N 434 
VAL HG11   H  N N 435 
VAL HG12   H  N N 436 
VAL HG13   H  N N 437 
VAL HG21   H  N N 438 
VAL HG22   H  N N 439 
VAL HG23   H  N N 440 
VAL HXT    H  N N 441 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CTP N1    C2     sing N N 70  
CTP N1    C6     sing N N 71  
CTP N1    "C1'"  sing N N 72  
CTP C2    N3     sing N N 73  
CTP C2    O2     doub N N 74  
CTP N3    C4     doub N N 75  
CTP C4    C5     sing N N 76  
CTP C4    N4     sing N N 77  
CTP C5    C6     doub N N 78  
CTP C5    H5     sing N N 79  
CTP C6    H6     sing N N 80  
CTP N4    HN41   sing N N 81  
CTP N4    HN42   sing N N 82  
CTP "C1'" "C2'"  sing N N 83  
CTP "C1'" "O4'"  sing N N 84  
CTP "C1'" "H1'"  sing N N 85  
CTP "C2'" "O2'"  sing N N 86  
CTP "C2'" "C3'"  sing N N 87  
CTP "C2'" "H2'"  sing N N 88  
CTP "O2'" "HO2'" sing N N 89  
CTP "C3'" "C4'"  sing N N 90  
CTP "C3'" "O3'"  sing N N 91  
CTP "C3'" "H3'"  sing N N 92  
CTP "C4'" "O4'"  sing N N 93  
CTP "C4'" "C5'"  sing N N 94  
CTP "C4'" "H4'"  sing N N 95  
CTP "O3'" "HO3'" sing N N 96  
CTP "C5'" "O5'"  sing N N 97  
CTP "C5'" "H5'1" sing N N 98  
CTP "C5'" "H5'2" sing N N 99  
CTP "O5'" PA     sing N N 100 
CTP PA    O1A    doub N N 101 
CTP PA    O2A    sing N N 102 
CTP PA    O3A    sing N N 103 
CTP O2A   HOA2   sing N N 104 
CTP O3A   PB     sing N N 105 
CTP PB    O1B    doub N N 106 
CTP PB    O2B    sing N N 107 
CTP PB    O3B    sing N N 108 
CTP O2B   HOB2   sing N N 109 
CTP O3B   PG     sing N N 110 
CTP PG    O1G    doub N N 111 
CTP PG    O2G    sing N N 112 
CTP PG    O3G    sing N N 113 
CTP O2G   HOG2   sing N N 114 
CTP O3G   HOG3   sing N N 115 
CYS N     CA     sing N N 116 
CYS N     H      sing N N 117 
CYS N     H2     sing N N 118 
CYS CA    C      sing N N 119 
CYS CA    CB     sing N N 120 
CYS CA    HA     sing N N 121 
CYS C     O      doub N N 122 
CYS C     OXT    sing N N 123 
CYS CB    SG     sing N N 124 
CYS CB    HB2    sing N N 125 
CYS CB    HB3    sing N N 126 
CYS SG    HG     sing N N 127 
CYS OXT   HXT    sing N N 128 
GLN N     CA     sing N N 129 
GLN N     H      sing N N 130 
GLN N     H2     sing N N 131 
GLN CA    C      sing N N 132 
GLN CA    CB     sing N N 133 
GLN CA    HA     sing N N 134 
GLN C     O      doub N N 135 
GLN C     OXT    sing N N 136 
GLN CB    CG     sing N N 137 
GLN CB    HB2    sing N N 138 
GLN CB    HB3    sing N N 139 
GLN CG    CD     sing N N 140 
GLN CG    HG2    sing N N 141 
GLN CG    HG3    sing N N 142 
GLN CD    OE1    doub N N 143 
GLN CD    NE2    sing N N 144 
GLN NE2   HE21   sing N N 145 
GLN NE2   HE22   sing N N 146 
GLN OXT   HXT    sing N N 147 
GLU N     CA     sing N N 148 
GLU N     H      sing N N 149 
GLU N     H2     sing N N 150 
GLU CA    C      sing N N 151 
GLU CA    CB     sing N N 152 
GLU CA    HA     sing N N 153 
GLU C     O      doub N N 154 
GLU C     OXT    sing N N 155 
GLU CB    CG     sing N N 156 
GLU CB    HB2    sing N N 157 
GLU CB    HB3    sing N N 158 
GLU CG    CD     sing N N 159 
GLU CG    HG2    sing N N 160 
GLU CG    HG3    sing N N 161 
GLU CD    OE1    doub N N 162 
GLU CD    OE2    sing N N 163 
GLU OE2   HE2    sing N N 164 
GLU OXT   HXT    sing N N 165 
GLY N     CA     sing N N 166 
GLY N     H      sing N N 167 
GLY N     H2     sing N N 168 
GLY CA    C      sing N N 169 
GLY CA    HA2    sing N N 170 
GLY CA    HA3    sing N N 171 
GLY C     O      doub N N 172 
GLY C     OXT    sing N N 173 
GLY OXT   HXT    sing N N 174 
HIS N     CA     sing N N 175 
HIS N     H      sing N N 176 
HIS N     H2     sing N N 177 
HIS CA    C      sing N N 178 
HIS CA    CB     sing N N 179 
HIS CA    HA     sing N N 180 
HIS C     O      doub N N 181 
HIS C     OXT    sing N N 182 
HIS CB    CG     sing N N 183 
HIS CB    HB2    sing N N 184 
HIS CB    HB3    sing N N 185 
HIS CG    ND1    sing Y N 186 
HIS CG    CD2    doub Y N 187 
HIS ND1   CE1    doub Y N 188 
HIS ND1   HD1    sing N N 189 
HIS CD2   NE2    sing Y N 190 
HIS CD2   HD2    sing N N 191 
HIS CE1   NE2    sing Y N 192 
HIS CE1   HE1    sing N N 193 
HIS NE2   HE2    sing N N 194 
HIS OXT   HXT    sing N N 195 
HOH O     H1     sing N N 196 
HOH O     H2     sing N N 197 
ILE N     CA     sing N N 198 
ILE N     H      sing N N 199 
ILE N     H2     sing N N 200 
ILE CA    C      sing N N 201 
ILE CA    CB     sing N N 202 
ILE CA    HA     sing N N 203 
ILE C     O      doub N N 204 
ILE C     OXT    sing N N 205 
ILE CB    CG1    sing N N 206 
ILE CB    CG2    sing N N 207 
ILE CB    HB     sing N N 208 
ILE CG1   CD1    sing N N 209 
ILE CG1   HG12   sing N N 210 
ILE CG1   HG13   sing N N 211 
ILE CG2   HG21   sing N N 212 
ILE CG2   HG22   sing N N 213 
ILE CG2   HG23   sing N N 214 
ILE CD1   HD11   sing N N 215 
ILE CD1   HD12   sing N N 216 
ILE CD1   HD13   sing N N 217 
ILE OXT   HXT    sing N N 218 
LEU N     CA     sing N N 219 
LEU N     H      sing N N 220 
LEU N     H2     sing N N 221 
LEU CA    C      sing N N 222 
LEU CA    CB     sing N N 223 
LEU CA    HA     sing N N 224 
LEU C     O      doub N N 225 
LEU C     OXT    sing N N 226 
LEU CB    CG     sing N N 227 
LEU CB    HB2    sing N N 228 
LEU CB    HB3    sing N N 229 
LEU CG    CD1    sing N N 230 
LEU CG    CD2    sing N N 231 
LEU CG    HG     sing N N 232 
LEU CD1   HD11   sing N N 233 
LEU CD1   HD12   sing N N 234 
LEU CD1   HD13   sing N N 235 
LEU CD2   HD21   sing N N 236 
LEU CD2   HD22   sing N N 237 
LEU CD2   HD23   sing N N 238 
LEU OXT   HXT    sing N N 239 
LYS N     CA     sing N N 240 
LYS N     H      sing N N 241 
LYS N     H2     sing N N 242 
LYS CA    C      sing N N 243 
LYS CA    CB     sing N N 244 
LYS CA    HA     sing N N 245 
LYS C     O      doub N N 246 
LYS C     OXT    sing N N 247 
LYS CB    CG     sing N N 248 
LYS CB    HB2    sing N N 249 
LYS CB    HB3    sing N N 250 
LYS CG    CD     sing N N 251 
LYS CG    HG2    sing N N 252 
LYS CG    HG3    sing N N 253 
LYS CD    CE     sing N N 254 
LYS CD    HD2    sing N N 255 
LYS CD    HD3    sing N N 256 
LYS CE    NZ     sing N N 257 
LYS CE    HE2    sing N N 258 
LYS CE    HE3    sing N N 259 
LYS NZ    HZ1    sing N N 260 
LYS NZ    HZ2    sing N N 261 
LYS NZ    HZ3    sing N N 262 
LYS OXT   HXT    sing N N 263 
MET N     CA     sing N N 264 
MET N     H      sing N N 265 
MET N     H2     sing N N 266 
MET CA    C      sing N N 267 
MET CA    CB     sing N N 268 
MET CA    HA     sing N N 269 
MET C     O      doub N N 270 
MET C     OXT    sing N N 271 
MET CB    CG     sing N N 272 
MET CB    HB2    sing N N 273 
MET CB    HB3    sing N N 274 
MET CG    SD     sing N N 275 
MET CG    HG2    sing N N 276 
MET CG    HG3    sing N N 277 
MET SD    CE     sing N N 278 
MET CE    HE1    sing N N 279 
MET CE    HE2    sing N N 280 
MET CE    HE3    sing N N 281 
MET OXT   HXT    sing N N 282 
PHE N     CA     sing N N 283 
PHE N     H      sing N N 284 
PHE N     H2     sing N N 285 
PHE CA    C      sing N N 286 
PHE CA    CB     sing N N 287 
PHE CA    HA     sing N N 288 
PHE C     O      doub N N 289 
PHE C     OXT    sing N N 290 
PHE CB    CG     sing N N 291 
PHE CB    HB2    sing N N 292 
PHE CB    HB3    sing N N 293 
PHE CG    CD1    doub Y N 294 
PHE CG    CD2    sing Y N 295 
PHE CD1   CE1    sing Y N 296 
PHE CD1   HD1    sing N N 297 
PHE CD2   CE2    doub Y N 298 
PHE CD2   HD2    sing N N 299 
PHE CE1   CZ     doub Y N 300 
PHE CE1   HE1    sing N N 301 
PHE CE2   CZ     sing Y N 302 
PHE CE2   HE2    sing N N 303 
PHE CZ    HZ     sing N N 304 
PHE OXT   HXT    sing N N 305 
PO4 P     O1     doub N N 306 
PO4 P     O2     sing N N 307 
PO4 P     O3     sing N N 308 
PO4 P     O4     sing N N 309 
PRO N     CA     sing N N 310 
PRO N     CD     sing N N 311 
PRO N     H      sing N N 312 
PRO CA    C      sing N N 313 
PRO CA    CB     sing N N 314 
PRO CA    HA     sing N N 315 
PRO C     O      doub N N 316 
PRO C     OXT    sing N N 317 
PRO CB    CG     sing N N 318 
PRO CB    HB2    sing N N 319 
PRO CB    HB3    sing N N 320 
PRO CG    CD     sing N N 321 
PRO CG    HG2    sing N N 322 
PRO CG    HG3    sing N N 323 
PRO CD    HD2    sing N N 324 
PRO CD    HD3    sing N N 325 
PRO OXT   HXT    sing N N 326 
SER N     CA     sing N N 327 
SER N     H      sing N N 328 
SER N     H2     sing N N 329 
SER CA    C      sing N N 330 
SER CA    CB     sing N N 331 
SER CA    HA     sing N N 332 
SER C     O      doub N N 333 
SER C     OXT    sing N N 334 
SER CB    OG     sing N N 335 
SER CB    HB2    sing N N 336 
SER CB    HB3    sing N N 337 
SER OG    HG     sing N N 338 
SER OXT   HXT    sing N N 339 
THR N     CA     sing N N 340 
THR N     H      sing N N 341 
THR N     H2     sing N N 342 
THR CA    C      sing N N 343 
THR CA    CB     sing N N 344 
THR CA    HA     sing N N 345 
THR C     O      doub N N 346 
THR C     OXT    sing N N 347 
THR CB    OG1    sing N N 348 
THR CB    CG2    sing N N 349 
THR CB    HB     sing N N 350 
THR OG1   HG1    sing N N 351 
THR CG2   HG21   sing N N 352 
THR CG2   HG22   sing N N 353 
THR CG2   HG23   sing N N 354 
THR OXT   HXT    sing N N 355 
TRP N     CA     sing N N 356 
TRP N     H      sing N N 357 
TRP N     H2     sing N N 358 
TRP CA    C      sing N N 359 
TRP CA    CB     sing N N 360 
TRP CA    HA     sing N N 361 
TRP C     O      doub N N 362 
TRP C     OXT    sing N N 363 
TRP CB    CG     sing N N 364 
TRP CB    HB2    sing N N 365 
TRP CB    HB3    sing N N 366 
TRP CG    CD1    doub Y N 367 
TRP CG    CD2    sing Y N 368 
TRP CD1   NE1    sing Y N 369 
TRP CD1   HD1    sing N N 370 
TRP CD2   CE2    doub Y N 371 
TRP CD2   CE3    sing Y N 372 
TRP NE1   CE2    sing Y N 373 
TRP NE1   HE1    sing N N 374 
TRP CE2   CZ2    sing Y N 375 
TRP CE3   CZ3    doub Y N 376 
TRP CE3   HE3    sing N N 377 
TRP CZ2   CH2    doub Y N 378 
TRP CZ2   HZ2    sing N N 379 
TRP CZ3   CH2    sing Y N 380 
TRP CZ3   HZ3    sing N N 381 
TRP CH2   HH2    sing N N 382 
TRP OXT   HXT    sing N N 383 
TYR N     CA     sing N N 384 
TYR N     H      sing N N 385 
TYR N     H2     sing N N 386 
TYR CA    C      sing N N 387 
TYR CA    CB     sing N N 388 
TYR CA    HA     sing N N 389 
TYR C     O      doub N N 390 
TYR C     OXT    sing N N 391 
TYR CB    CG     sing N N 392 
TYR CB    HB2    sing N N 393 
TYR CB    HB3    sing N N 394 
TYR CG    CD1    doub Y N 395 
TYR CG    CD2    sing Y N 396 
TYR CD1   CE1    sing Y N 397 
TYR CD1   HD1    sing N N 398 
TYR CD2   CE2    doub Y N 399 
TYR CD2   HD2    sing N N 400 
TYR CE1   CZ     doub Y N 401 
TYR CE1   HE1    sing N N 402 
TYR CE2   CZ     sing Y N 403 
TYR CE2   HE2    sing N N 404 
TYR CZ    OH     sing N N 405 
TYR OH    HH     sing N N 406 
TYR OXT   HXT    sing N N 407 
VAL N     CA     sing N N 408 
VAL N     H      sing N N 409 
VAL N     H2     sing N N 410 
VAL CA    C      sing N N 411 
VAL CA    CB     sing N N 412 
VAL CA    HA     sing N N 413 
VAL C     O      doub N N 414 
VAL C     OXT    sing N N 415 
VAL CB    CG1    sing N N 416 
VAL CB    CG2    sing N N 417 
VAL CB    HB     sing N N 418 
VAL CG1   HG11   sing N N 419 
VAL CG1   HG12   sing N N 420 
VAL CG1   HG13   sing N N 421 
VAL CG2   HG21   sing N N 422 
VAL CG2   HG22   sing N N 423 
VAL CG2   HG23   sing N N 424 
VAL OXT   HXT    sing N N 425 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           111-2311-B-039-001-MY3 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'apo DwCdnB' 
# 
_atom_sites.entry_id                    8YSM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028248 
_atom_sites.fract_transf_matrix[1][2]   0.004639 
_atom_sites.fract_transf_matrix[1][3]   0.008614 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.021670 
_atom_sites.fract_transf_matrix[2][3]   0.007229 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.016881 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H  1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
MN 25 25 11.285 5.341  7.360 0.343  3.020 17.867 2.245 83.754 1.090   
N  7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O  8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
P  15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491 68.164 1.115   
S  16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N     . MET A 1 1   ? -2.124  15.525  27.447  1.000 20.652 0 1   MET A N     1 ? 
ATOM   2    C  CA    . MET A 1 1   ? -1.588  14.943  26.103  1.000 20.327 0 1   MET A CA    1 ? 
ATOM   3    C  C     . MET A 1 1   ? -0.512  13.915  26.378  1.000 20.348 0 1   MET A C     1 ? 
ATOM   4    O  O     . MET A 1 1   ? 0.342   14.185  27.229  1.000 23.364 0 1   MET A O     1 ? 
ATOM   5    C  CB    . MET A 1 1   ? -0.964  16.024  25.226  1.000 23.966 0 1   MET A CB    1 ? 
ATOM   6    C  CG    . MET A 1 1   ? -1.950  16.947  24.666  1.000 26.486 0 1   MET A CG    1 ? 
ATOM   7    S  SD    . MET A 1 1   ? -2.779  16.205  23.265  1.000 30.661 0 1   MET A SD    1 ? 
ATOM   8    C  CE    . MET A 1 1   ? -1.560  16.517  21.988  1.000 22.563 0 1   MET A CE    1 ? 
ATOM   9    N  N     . ALA A 1 2   ? -0.580  12.784  25.688  1.000 16.577 0 2   ALA A N     1 ? 
ATOM   10   C  CA    . ALA A 1 2   ? 0.400   11.685  25.694  1.000 17.293 0 2   ALA A CA    1 ? 
ATOM   11   C  C     . ALA A 1 2   ? 1.742   12.224  25.233  1.000 16.856 0 2   ALA A C     1 ? 
ATOM   12   O  O     . ALA A 1 2   ? 1.838   13.227  24.458  1.000 14.917 0 2   ALA A O     1 ? 
ATOM   13   C  CB    . ALA A 1 2   ? -0.075  10.546  24.819  1.000 18.823 0 2   ALA A CB    1 ? 
ATOM   14   N  N     . PRO A 1 3   ? 2.834   11.597  25.716  1.000 18.846 0 3   PRO A N     1 ? 
ATOM   15   C  CA    . PRO A 1 3   ? 4.162   12.007  25.315  1.000 16.996 0 3   PRO A CA    1 ? 
ATOM   16   C  C     . PRO A 1 3   ? 4.300   12.011  23.785  1.000 12.483 0 3   PRO A C     1 ? 
ATOM   17   O  O     . PRO A 1 3   ? 3.788   11.042  23.180  1.000 13.887 0 3   PRO A O     1 ? 
ATOM   18   C  CB    . PRO A 1 3   ? 5.081   10.944  25.937  1.000 18.752 0 3   PRO A CB    1 ? 
ATOM   19   C  CG    . PRO A 1 3   ? 4.314   10.438  27.138  1.000 21.770 0 3   PRO A CG    1 ? 
ATOM   20   C  CD    . PRO A 1 3   ? 2.846   10.557  26.765  1.000 19.387 0 3   PRO A CD    1 ? 
ATOM   21   N  N     . VAL A 1 4   ? 4.863   13.093  23.230  1.000 12.441 0 4   VAL A N     1 ? 
ATOM   22   C  CA    . VAL A 1 4   ? 5.225   13.255  21.786  1.000 11.851 0 4   VAL A CA    1 ? 
ATOM   23   C  C     . VAL A 1 4   ? 3.976   13.241  20.889  1.000 9.966  0 4   VAL A C     1 ? 
ATOM   24   O  O     . VAL A 1 4   ? 4.118   13.234  19.654  1.000 10.137 0 4   VAL A O     1 ? 
ATOM   25   C  CB    . VAL A 1 4   ? 6.309   12.241  21.351  1.000 14.214 0 4   VAL A CB    1 ? 
ATOM   26   C  CG1   . VAL A 1 4   ? 7.510   12.343  22.277  1.000 17.259 0 4   VAL A CG1   1 ? 
ATOM   27   C  CG2   . VAL A 1 4   ? 5.855   10.836  21.285  1.000 17.233 0 4   VAL A CG2   1 ? 
ATOM   28   N  N     . GLN A 1 5   ? 2.767   13.312  21.451  1.000 8.784  0 5   GLN A N     1 ? 
ATOM   29   C  CA    . GLN A 1 5   ? 1.570   13.295  20.581  1.000 8.366  0 5   GLN A CA    1 ? 
ATOM   30   C  C     . GLN A 1 5   ? 1.534   14.510  19.653  1.000 8.025  0 5   GLN A C     1 ? 
ATOM   31   O  O     . GLN A 1 5   ? 1.187   14.349  18.455  1.000 8.011  0 5   GLN A O     1 ? 
ATOM   32   C  CB    . GLN A 1 5   ? 0.290   13.213  21.401  1.000 7.938  0 5   GLN A CB    1 ? 
ATOM   33   C  CG    . GLN A 1 5   ? -0.972  13.081  20.544  1.000 7.828  0 5   GLN A CG    1 ? 
ATOM   34   C  CD    . GLN A 1 5   ? -1.056  11.774  19.784  1.000 8.584  0 5   GLN A CD    1 ? 
ATOM   35   O  OE1   . GLN A 1 5   ? -0.233  10.854  19.934  1.000 8.138  0 5   GLN A OE1   1 ? 
ATOM   36   N  NE2   . GLN A 1 5   ? -2.096  11.640  18.997  1.000 8.429  0 5   GLN A NE2   1 ? 
ATOM   37   N  N     . LYS A 1 6   ? 1.866   15.713  20.112  1.000 8.632  0 6   LYS A N     1 ? 
ATOM   38   C  CA    . LYS A 1 6   ? 1.835   16.884  19.231  1.000 9.186  0 6   LYS A CA    1 ? 
ATOM   39   C  C     . LYS A 1 6   ? 2.724   16.620  18.022  1.000 8.657  0 6   LYS A C     1 ? 
ATOM   40   O  O     . LYS A 1 6   ? 2.344   16.959  16.906  1.000 8.324  0 6   LYS A O     1 ? 
ATOM   41   C  CB    . LYS A 1 6   ? 2.301   18.139  19.981  1.000 11.393 0 6   LYS A CB    1 ? 
ATOM   42   C  CG    . LYS A 1 6   ? 2.167   19.431  19.204  1.000 14.188 0 6   LYS A CG    1 ? 
ATOM   43   C  CD    . LYS A 1 6   ? 2.855   20.582  19.874  1.000 20.569 0 6   LYS A CD    1 ? 
ATOM   44   C  CE    . LYS A 1 6   ? 3.468   21.545  18.896  1.000 24.928 0 6   LYS A CE    1 ? 
ATOM   45   N  NZ    . LYS A 1 6   ? 2.445   22.126  18.021  1.000 32.230 0 6   LYS A NZ    1 ? 
ATOM   46   N  N     . GLN A 1 7   ? 3.907   16.096  18.262  1.000 8.099  0 7   GLN A N     1 ? 
ATOM   47   C  CA    . GLN A 1 7   ? 4.913   15.876  17.215  1.000 8.449  0 7   GLN A CA    1 ? 
ATOM   48   C  C     . GLN A 1 7   ? 4.438   14.757  16.258  1.000 7.966  0 7   GLN A C     1 ? 
ATOM   49   O  O     . GLN A 1 7   ? 4.636   14.911  15.047  1.000 7.404  0 7   GLN A O     1 ? 
ATOM   50   C  CB    . GLN A 1 7   ? 6.249   15.565  17.869  1.000 9.496  0 7   GLN A CB    1 ? 
ATOM   51   C  CG    . GLN A 1 7   ? 6.889   16.824  18.465  1.000 10.077 0 7   GLN A CG    1 ? 
ATOM   52   C  CD    . GLN A 1 7   ? 6.288   17.240  19.771  1.000 11.805 0 7   GLN A CD    1 ? 
ATOM   53   O  OE1   . GLN A 1 7   ? 5.850   16.418  20.541  1.000 12.077 0 7   GLN A OE1   1 ? 
ATOM   54   N  NE2   . GLN A 1 7   ? 6.192   18.546  19.977  1.000 14.430 0 7   GLN A NE2   1 ? 
ATOM   55   N  N     . PHE A 1 8   ? 3.794   13.691  16.764  1.000 7.112  0 8   PHE A N     1 ? 
ATOM   56   C  CA    . PHE A 1 8   ? 3.229   12.694  15.837  1.000 6.756  0 8   PHE A CA    1 ? 
ATOM   57   C  C     . PHE A 1 8   ? 2.148   13.351  14.980  1.000 6.894  0 8   PHE A C     1 ? 
ATOM   58   O  O     . PHE A 1 8   ? 2.122   13.110  13.753  1.000 6.354  0 8   PHE A O     1 ? 
ATOM   59   C  CB    . PHE A 1 8   ? 2.700   11.466  16.557  1.000 7.043  0 8   PHE A CB    1 ? 
ATOM   60   C  CG    . PHE A 1 8   ? 3.735   10.394  16.665  1.000 8.527  0 8   PHE A CG    1 ? 
ATOM   61   C  CD1   . PHE A 1 8   ? 4.085   9.655   15.531  1.000 9.160  0 8   PHE A CD1   1 ? 
ATOM   62   C  CD2   . PHE A 1 8   ? 4.334   10.078  17.883  1.000 9.873  0 8   PHE A CD2   1 ? 
ATOM   63   C  CE1   . PHE A 1 8   ? 5.029   8.638   15.618  1.000 9.974  0 8   PHE A CE1   1 ? 
ATOM   64   C  CE2   . PHE A 1 8   ? 5.296   9.072   17.958  1.000 10.645 0 8   PHE A CE2   1 ? 
ATOM   65   C  CZ    . PHE A 1 8   ? 5.592   8.343   16.841  1.000 10.034 0 8   PHE A CZ    1 ? 
ATOM   66   N  N     . ARG A 1 9   ? 1.262   14.146  15.565  1.000 6.906  0 9   ARG A N     1 ? 
ATOM   67   C  CA    . ARG A 1 9   ? 0.184   14.731  14.774  1.000 6.756  0 9   ARG A CA    1 ? 
ATOM   68   C  C     . ARG A 1 9   ? 0.762   15.711  13.745  1.000 6.150  0 9   ARG A C     1 ? 
ATOM   69   O  O     . ARG A 1 9   ? 0.256   15.773  12.610  1.000 7.472  0 9   ARG A O     1 ? 
ATOM   70   C  CB    . ARG A 1 9   ? -0.849  15.391  15.675  1.000 7.074  0 9   ARG A CB    1 ? 
ATOM   71   C  CG    . ARG A 1 9   ? -1.652  14.416  16.512  1.000 7.904  0 9   ARG A CG    1 ? 
ATOM   72   C  CD    . ARG A 1 9   ? -2.466  13.442  15.689  1.000 8.961  0 9   ARG A CD    1 ? 
ATOM   73   N  NE    . ARG A 1 9   ? -3.385  14.017  14.767  1.000 10.615 0 9   ARG A NE    1 ? 
ATOM   74   C  CZ    . ARG A 1 9   ? -4.666  14.256  15.013  1.000 12.672 0 9   ARG A CZ    1 ? 
ATOM   75   N  NH1   . ARG A 1 9   ? -5.189  13.971  16.191  1.000 12.401 0 9   ARG A NH1   1 ? 
ATOM   76   N  NH2   . ARG A 1 9   ? -5.413  14.752  14.046  1.000 15.857 0 9   ARG A NH2   1 ? 
ATOM   77   N  N     . GLU A 1 10  ? 1.803   16.455  14.084  1.000 6.850  0 10  GLU A N     1 ? 
ATOM   78   C  CA    . GLU A 1 10  ? 2.470   17.360  13.143  1.000 7.538  0 10  GLU A CA    1 ? 
ATOM   79   C  C     . GLU A 1 10  ? 3.149   16.559  12.025  1.000 7.361  0 10  GLU A C     1 ? 
ATOM   80   O  O     . GLU A 1 10  ? 2.973   16.848  10.842  1.000 7.612  0 10  GLU A O     1 ? 
ATOM   81   C  CB    . GLU A 1 10  ? 3.479   18.231  13.887  1.000 8.522  0 10  GLU A CB    1 ? 
ATOM   82   C  CG    . GLU A 1 10  ? 4.320   19.080  12.965  1.000 9.898  0 10  GLU A CG    1 ? 
ATOM   83   C  CD    . GLU A 1 10  ? 3.594   20.140  12.122  1.000 10.723 0 10  GLU A CD    1 ? 
ATOM   84   O  OE1   . GLU A 1 10  ? 2.495   20.589  12.577  1.000 12.475 0 10  GLU A OE1   1 ? 
ATOM   85   O  OE2   . GLU A 1 10  ? 4.035   20.449  10.964  1.000 10.017 0 10  GLU A OE2   1 ? 
ATOM   86   N  N     . PHE A 1 11  ? 3.836   15.483  12.380  1.000 6.841  0 11  PHE A N     1 ? 
ATOM   87   C  CA    . PHE A 1 11  ? 4.419   14.560  11.393  1.000 6.921  0 11  PHE A CA    1 ? 
ATOM   88   C  C     . PHE A 1 11  ? 3.337   14.049  10.432  1.000 6.374  0 11  PHE A C     1 ? 
ATOM   89   O  O     . PHE A 1 11  ? 3.524   14.065  9.221   1.000 6.162  0 11  PHE A O     1 ? 
ATOM   90   C  CB    . PHE A 1 11  ? 5.096   13.410  12.129  1.000 6.327  0 11  PHE A CB    1 ? 
ATOM   91   C  CG    . PHE A 1 11  ? 5.748   12.388  11.241  1.000 6.186  0 11  PHE A CG    1 ? 
ATOM   92   C  CD1   . PHE A 1 11  ? 6.711   12.748  10.325  1.000 6.831  0 11  PHE A CD1   1 ? 
ATOM   93   C  CD2   . PHE A 1 11  ? 5.498   11.046  11.442  1.000 6.294  0 11  PHE A CD2   1 ? 
ATOM   94   C  CE1   . PHE A 1 11  ? 7.338   11.810  9.536   1.000 7.274  0 11  PHE A CE1   1 ? 
ATOM   95   C  CE2   . PHE A 1 11  ? 6.167   10.084  10.692  1.000 6.800  0 11  PHE A CE2   1 ? 
ATOM   96   C  CZ    . PHE A 1 11  ? 7.073   10.470  9.737   1.000 6.968  0 11  PHE A CZ    1 ? 
ATOM   97   N  N     . HIS A 1 12  ? 2.196   13.622  10.988  1.000 6.083  0 12  HIS A N     1 ? 
ATOM   98   C  CA    . HIS A 1 12  ? 1.103   13.131  10.118  1.000 6.049  0 12  HIS A CA    1 ? 
ATOM   99   C  C     . HIS A 1 12  ? 0.691   14.230  9.141   1.000 6.797  0 12  HIS A C     1 ? 
ATOM   100  O  O     . HIS A 1 12  ? 0.496   13.946  7.946   1.000 6.973  0 12  HIS A O     1 ? 
ATOM   101  C  CB    . HIS A 1 12  ? -0.101  12.690  10.929  1.000 6.259  0 12  HIS A CB    1 ? 
ATOM   102  C  CG    . HIS A 1 12  ? -1.188  12.140  10.100  1.000 6.442  0 12  HIS A CG    1 ? 
ATOM   103  N  ND1   . HIS A 1 12  ? -2.409  12.746  10.020  1.000 6.969  0 12  HIS A ND1   1 ? 
ATOM   104  C  CD2   . HIS A 1 12  ? -1.226  11.100  9.230   1.000 7.291  0 12  HIS A CD2   1 ? 
ATOM   105  C  CE1   . HIS A 1 12  ? -3.130  12.081  9.133   1.000 7.070  0 12  HIS A CE1   1 ? 
ATOM   106  N  NE2   . HIS A 1 12  ? -2.446  11.082  8.678   1.000 7.380  0 12  HIS A NE2   1 ? 
ATOM   107  N  N     . ASP A 1 13  ? 0.543   15.453  9.608   1.000 6.731  0 13  ASP A N     1 ? 
ATOM   108  C  CA    . ASP A 1 13  ? 0.091   16.556  8.745   1.000 8.127  0 13  ASP A CA    1 ? 
ATOM   109  C  C     . ASP A 1 13  ? 1.118   16.796  7.622   1.000 7.562  0 13  ASP A C     1 ? 
ATOM   110  O  O     . ASP A 1 13  ? 0.698   17.166  6.523   1.000 9.236  0 13  ASP A O     1 ? 
ATOM   111  C  CB    . ASP A 1 13  ? -0.143  17.816  9.538   1.000 9.373  0 13  ASP A CB    1 ? 
ATOM   112  C  CG    . ASP A 1 13  ? -1.400  17.780  10.385  1.000 11.160 0 13  ASP A CG    1 ? 
ATOM   113  O  OD1   . ASP A 1 13  ? -2.260  16.920  10.138  1.000 10.748 0 13  ASP A OD1   1 ? 
ATOM   114  O  OD2   . ASP A 1 13  ? -1.500  18.617  11.314  1.000 13.789 0 13  ASP A OD2   1 ? 
ATOM   115  N  N     . ARG A 1 14  ? 2.402   16.557  7.876   1.000 7.864  0 14  ARG A N     1 ? 
ATOM   116  C  CA    . ARG A 1 14  ? 3.447   16.737  6.845   1.000 7.300  0 14  ARG A CA    1 ? 
ATOM   117  C  C     . ARG A 1 14  ? 3.412   15.629  5.803   1.000 7.185  0 14  ARG A C     1 ? 
ATOM   118  O  O     . ARG A 1 14  ? 3.776   15.896  4.645   1.000 8.542  0 14  ARG A O     1 ? 
ATOM   119  C  CB    . ARG A 1 14  ? 4.818   16.815  7.484   1.000 7.670  0 14  ARG A CB    1 ? 
ATOM   120  C  CG    . ARG A 1 14  ? 4.968   18.009  8.437   1.000 7.302  0 14  ARG A CG    1 ? 
ATOM   121  C  CD    . ARG A 1 14  ? 6.254   18.010  9.219   1.000 7.043  0 14  ARG A CD    1 ? 
ATOM   122  N  NE    . ARG A 1 14  ? 6.373   19.161  10.115  1.000 7.882  0 14  ARG A NE    1 ? 
ATOM   123  C  CZ    . ARG A 1 14  ? 7.457   19.472  10.752  1.000 9.065  0 14  ARG A CZ    1 ? 
ATOM   124  N  NH1   . ARG A 1 14  ? 8.526   18.690  10.701  1.000 9.270  0 14  ARG A NH1   1 ? 
ATOM   125  N  NH2   . ARG A 1 14  ? 7.472   20.579  11.491  1.000 10.129 0 14  ARG A NH2   1 ? 
ATOM   126  N  N     . ILE A 1 15  ? 3.165   14.375  6.223   1.000 7.277  0 15  ILE A N     1 ? 
ATOM   127  C  CA    . ILE A 1 15  ? 3.321   13.241  5.295   1.000 6.706  0 15  ILE A CA    1 ? 
ATOM   128  C  C     . ILE A 1 15  ? 2.034   12.928  4.591   1.000 7.031  0 15  ILE A C     1 ? 
ATOM   129  O  O     . ILE A 1 15  ? 2.096   12.189  3.600   1.000 7.248  0 15  ILE A O     1 ? 
ATOM   130  C  CB    . ILE A 1 15  ? 3.872   12.015  6.045   1.000 6.562  0 15  ILE A CB    1 ? 
ATOM   131  C  CG1   . ILE A 1 15  ? 2.843   11.385  6.983   1.000 6.267  0 15  ILE A CG1   1 ? 
ATOM   132  C  CG2   . ILE A 1 15  ? 5.182   12.371  6.742   1.000 7.299  0 15  ILE A CG2   1 ? 
ATOM   133  C  CD1   . ILE A 1 15  ? 3.378   10.177  7.748   1.000 7.657  0 15  ILE A CD1   1 ? 
ATOM   134  N  N     . LYS A 1 16  ? 0.886   13.309  5.116   1.000 6.640  0 16  LYS A N     1 ? 
ATOM   135  C  CA    . LYS A 1 16  ? -0.384  12.822  4.573   1.000 8.190  0 16  LYS A CA    1 ? 
ATOM   136  C  C     . LYS A 1 16  ? -0.605  13.373  3.157   1.000 8.645  0 16  LYS A C     1 ? 
ATOM   137  O  O     . LYS A 1 16  ? -0.213  14.499  2.869   1.000 8.900  0 16  LYS A O     1 ? 
ATOM   138  C  CB    . LYS A 1 16  ? -1.546  13.174  5.479   1.000 8.696  0 16  LYS A CB    1 ? 
ATOM   139  C  CG    . LYS A 1 16  ? -1.830  14.647  5.671   1.000 10.016 0 16  LYS A CG    1 ? 
ATOM   140  C  CD    . LYS A 1 16  ? -2.853  14.913  6.721   1.000 10.125 0 16  LYS A CD    1 ? 
ATOM   141  C  CE    . LYS A 1 16  ? -3.302  16.352  6.701   1.000 11.047 0 16  LYS A CE    1 ? 
ATOM   142  N  NZ    . LYS A 1 16  ? -4.061  16.710  7.912   1.000 13.505 0 16  LYS A NZ    1 ? 
ATOM   143  N  N     . LEU A 1 17  ? -1.223  12.566  2.294   1.000 10.099 0 17  LEU A N     1 ? 
ATOM   144  C  CA    . LEU A 1 17  ? -1.664  13.001  0.967   1.000 10.760 0 17  LEU A CA    1 ? 
ATOM   145  C  C     . LEU A 1 17  ? -3.170  12.917  0.914   1.000 11.101 0 17  LEU A C     1 ? 
ATOM   146  O  O     . LEU A 1 17  ? -3.746  11.893  1.354   1.000 12.340 0 17  LEU A O     1 ? 
ATOM   147  C  CB    . LEU A 1 17  ? -1.027  12.093  -0.048  1.000 11.342 0 17  LEU A CB    1 ? 
ATOM   148  C  CG    . LEU A 1 17  ? -1.350  12.399  -1.474  1.000 12.510 0 17  LEU A CG    1 ? 
ATOM   149  C  CD1   . LEU A 1 17  ? -0.896  13.803  -1.806  1.000 14.268 0 17  LEU A CD1   1 ? 
ATOM   150  C  CD2   . LEU A 1 17  ? -0.681  11.363  -2.360  1.000 14.445 0 17  LEU A CD2   1 ? 
ATOM   151  N  N     . ALA A 1 18  ? -3.821  13.951  0.430   1.000 11.922 0 18  ALA A N     1 ? 
ATOM   152  C  CA    . ALA A 1 18  ? -5.280  13.951  0.263   1.000 12.903 0 18  ALA A CA    1 ? 
ATOM   153  C  C     . ALA A 1 18  ? -5.721  12.803  -0.684  1.000 10.429 0 18  ALA A C     1 ? 
ATOM   154  O  O     . ALA A 1 18  ? -5.095  12.605  -1.725  1.000 11.887 0 18  ALA A O     1 ? 
ATOM   155  C  CB    . ALA A 1 18  ? -5.727  15.314  -0.264  1.000 13.537 0 18  ALA A CB    1 ? 
ATOM   156  N  N     . GLN A 1 19  ? -6.759  12.104  -0.281  1.000 10.991 0 19  GLN A N     1 ? 
ATOM   157  C  CA    . GLN A 1 19  ? -7.347  10.962  -1.010  1.000 11.849 0 19  GLN A CA    1 ? 
ATOM   158  C  C     . GLN A 1 19  ? -7.989  11.455  -2.315  1.000 13.522 0 19  GLN A C     1 ? 
ATOM   159  O  O     . GLN A 1 19  ? -8.194  12.653  -2.470  1.000 13.915 0 19  GLN A O     1 ? 
ATOM   160  C  CB    . GLN A 1 19  ? -8.366  10.259  -0.123  1.000 12.398 0 19  GLN A CB    1 ? 
ATOM   161  C  CG    . GLN A 1 19  ? -9.602  11.098  0.130   1.000 14.494 0 19  GLN A CG    1 ? 
ATOM   162  C  CD    . GLN A 1 19  ? -10.615 10.351  0.950   1.000 15.696 0 19  GLN A CD    1 ? 
ATOM   163  O  OE1   . GLN A 1 19  ? -10.978 9.217   0.620   1.000 19.468 0 19  GLN A OE1   1 ? 
ATOM   164  N  NE2   . GLN A 1 19  ? -10.976 10.906  2.097   1.000 17.556 0 19  GLN A NE2   1 ? 
ATOM   165  N  N     . TYR A 1 20  ? -8.313  10.523  -3.214  1.000 14.254 0 20  TYR A N     1 ? 
ATOM   166  C  CA    . TYR A 1 20  ? -8.853  10.874  -4.550  1.000 13.664 0 20  TYR A CA    1 ? 
ATOM   167  C  C     . TYR A 1 20  ? -9.989  11.895  -4.383  1.000 14.253 0 20  TYR A C     1 ? 
ATOM   168  O  O     . TYR A 1 20  ? -9.909  12.957  -5.097  1.000 16.258 0 20  TYR A O     1 ? 
ATOM   169  C  CB    . TYR A 1 20  ? -9.362  9.636   -5.291  1.000 13.165 0 20  TYR A CB    1 ? 
ATOM   170  C  CG    . TYR A 1 20  ? -8.311  8.780   -5.949  1.000 12.577 0 20  TYR A CG    1 ? 
ATOM   171  C  CD1   . TYR A 1 20  ? -7.413  9.265   -6.899  1.000 13.231 0 20  TYR A CD1   1 ? 
ATOM   172  C  CD2   . TYR A 1 20  ? -8.278  7.413   -5.684  1.000 12.381 0 20  TYR A CD2   1 ? 
ATOM   173  C  CE1   . TYR A 1 20  ? -6.494  8.435   -7.529  1.000 14.296 0 20  TYR A CE1   1 ? 
ATOM   174  C  CE2   . TYR A 1 20  ? -7.382  6.572   -6.316  1.000 13.488 0 20  TYR A CE2   1 ? 
ATOM   175  C  CZ    . TYR A 1 20  ? -6.495  7.070   -7.257  1.000 14.225 0 20  TYR A CZ    1 ? 
ATOM   176  O  OH    . TYR A 1 20  ? -5.596  6.244   -7.878  1.000 17.637 0 20  TYR A OH    1 ? 
ATOM   177  N  N     . ASP A 1 21  ? -10.980 11.613  -3.539  1.000 15.563 0 21  ASP A N     1 ? 
ATOM   178  C  CA    . ASP A 1 21  ? -12.231 12.428  -3.406  1.000 18.457 0 21  ASP A CA    1 ? 
ATOM   179  C  C     . ASP A 1 21  ? -11.883 13.854  -2.926  1.000 20.512 0 21  ASP A C     1 ? 
ATOM   180  O  O     . ASP A 1 21  ? -12.740 14.749  -3.063  1.000 22.332 0 21  ASP A O     1 ? 
ATOM   181  C  CB    . ASP A 1 21  ? -13.242 11.745  -2.498  1.000 20.011 0 21  ASP A CB    1 ? 
ATOM   182  C  CG    . ASP A 1 21  ? -13.867 10.479  -3.075  1.000 22.777 0 21  ASP A CG    1 ? 
ATOM   183  O  OD1   . ASP A 1 21  ? -14.586 9.800   -2.344  1.000 31.300 0 21  ASP A OD1   1 ? 
ATOM   184  O  OD2   . ASP A 1 21  ? -13.595 10.179  -4.216  1.000 28.417 0 21  ASP A OD2   1 ? 
ATOM   185  N  N     . GLU A 1 22  ? -10.673 14.080  -2.397  1.000 18.557 0 22  GLU A N     1 ? 
ATOM   186  C  CA    . GLU A 1 22  ? -10.255 15.410  -1.891  1.000 19.270 0 22  GLU A CA    1 ? 
ATOM   187  C  C     . GLU A 1 22  ? -9.082  15.959  -2.673  1.000 19.433 0 22  GLU A C     1 ? 
ATOM   188  O  O     . GLU A 1 22  ? -8.474  16.949  -2.188  1.000 21.127 0 22  GLU A O     1 ? 
ATOM   189  C  CB    . GLU A 1 22  ? -9.868  15.325  -0.412  1.000 21.974 0 22  GLU A CB    1 ? 
ATOM   190  C  CG    . GLU A 1 22  ? -10.973 14.830  0.473   1.000 24.116 0 22  GLU A CG    1 ? 
ATOM   191  C  CD    . GLU A 1 22  ? -10.595 14.782  1.939   1.000 30.895 0 22  GLU A CD    1 ? 
ATOM   192  O  OE1   . GLU A 1 22  ? -10.346 15.848  2.510   1.000 37.857 0 22  GLU A OE1   1 ? 
ATOM   193  O  OE2   . GLU A 1 22  ? -10.511 13.678  2.492   1.000 33.434 0 22  GLU A OE2   1 ? 
ATOM   194  N  N     . ASN A 1 23  ? -8.696  15.353  -3.799  1.000 17.292 0 23  ASN A N     1 ? 
ATOM   195  C  CA    . ASN A 1 23  ? -7.425  15.659  -4.468  1.000 17.603 0 23  ASN A CA    1 ? 
ATOM   196  C  C     . ASN A 1 23  ? -7.653  15.792  -5.986  1.000 20.738 0 23  ASN A C     1 ? 
ATOM   197  O  O     . ASN A 1 23  ? -7.593  14.764  -6.705  1.000 19.877 0 23  ASN A O     1 ? 
ATOM   198  C  CB    . ASN A 1 23  ? -6.346  14.628  -4.108  1.000 17.370 0 23  ASN A CB    1 ? 
ATOM   199  C  CG    . ASN A 1 23  ? -4.950  15.100  -4.438  1.000 17.257 0 23  ASN A CG    1 ? 
ATOM   200  O  OD1   . ASN A 1 23  ? -4.723  15.801  -5.436  1.000 19.780 0 23  ASN A OD1   1 ? 
ATOM   201  N  ND2   . ASN A 1 23  ? -3.957  14.722  -3.629  1.000 15.579 0 23  ASN A ND2   1 ? 
ATOM   202  N  N     . GLN A 1 24  ? -7.817  17.031  -6.464  1.000 22.426 0 24  GLN A N     1 ? 
ATOM   203  C  CA    . GLN A 1 24  ? -8.137  17.306  -7.883  1.000 26.155 0 24  GLN A CA    1 ? 
ATOM   204  C  C     . GLN A 1 24  ? -6.975  16.850  -8.750  1.000 21.729 0 24  GLN A C     1 ? 
ATOM   205  O  O     . GLN A 1 24  ? -7.231  16.260  -9.830  1.000 25.381 0 24  GLN A O     1 ? 
ATOM   206  C  CB    . GLN A 1 24  ? -8.438  18.794  -8.101  1.000 29.182 0 24  GLN A CB    1 ? 
ATOM   207  C  CG    . GLN A 1 24  ? -8.880  19.108  -9.526  1.000 31.006 0 24  GLN A CG    1 ? 
ATOM   208  C  CD    . GLN A 1 24  ? -10.307 18.690  -9.784  1.000 35.616 0 24  GLN A CD    1 ? 
ATOM   209  O  OE1   . GLN A 1 24  ? -10.573 17.757  -10.534 1.000 45.059 0 24  GLN A OE1   1 ? 
ATOM   210  N  NE2   . GLN A 1 24  ? -11.245 19.380  -9.153  1.000 40.382 0 24  GLN A NE2   1 ? 
ATOM   211  N  N     . THR A 1 25  ? -5.740  17.146  -8.360  1.000 22.353 0 25  THR A N     1 ? 
ATOM   212  C  CA    . THR A 1 25  ? -4.532  16.768  -9.125  1.000 23.542 0 25  THR A CA    1 ? 
ATOM   213  C  C     . THR A 1 25  ? -4.561  15.250  -9.388  1.000 23.914 0 25  THR A C     1 ? 
ATOM   214  O  O     . THR A 1 25  ? -4.361  14.855  -10.518 1.000 23.941 0 25  THR A O     1 ? 
ATOM   215  C  CB    . THR A 1 25  ? -3.243  17.187  -8.414  1.000 28.853 0 25  THR A CB    1 ? 
ATOM   216  O  OG1   . THR A 1 25  ? -3.279  18.600  -8.233  1.000 32.882 0 25  THR A OG1   1 ? 
ATOM   217  C  CG2   . THR A 1 25  ? -2.007  16.802  -9.190  1.000 29.985 0 25  THR A CG2   1 ? 
ATOM   218  N  N     . LEU A 1 26  ? -4.763  14.423  -8.364  1.000 21.245 0 26  LEU A N     1 ? 
ATOM   219  C  CA    . LEU A 1 26  ? -4.709  12.956  -8.571  1.000 19.697 0 26  LEU A CA    1 ? 
ATOM   220  C  C     . LEU A 1 26  ? -5.864  12.541  -9.486  1.000 18.043 0 26  LEU A C     1 ? 
ATOM   221  O  O     . LEU A 1 26  ? -5.628  11.635  -10.288 1.000 18.890 0 26  LEU A O     1 ? 
ATOM   222  C  CB    . LEU A 1 26  ? -4.785  12.211  -7.231  1.000 16.863 0 26  LEU A CB    1 ? 
ATOM   223  C  CG    . LEU A 1 26  ? -3.580  12.356  -6.311  1.000 17.024 0 26  LEU A CG    1 ? 
ATOM   224  C  CD1   . LEU A 1 26  ? -3.868  11.634  -4.979  1.000 16.104 0 26  LEU A CD1   1 ? 
ATOM   225  C  CD2   . LEU A 1 26  ? -2.325  11.853  -6.949  1.000 17.733 0 26  LEU A CD2   1 ? 
ATOM   226  N  N     . ARG A 1 27  ? -7.063  13.078  -9.282  1.000 18.218 0 27  ARG A N     1 ? 
ATOM   227  C  CA    . ARG A 1 27  ? -8.253  12.735  -10.103 1.000 19.043 0 27  ARG A CA    1 ? 
ATOM   228  C  C     . ARG A 1 27  ? -7.940  13.063  -11.574 1.000 21.765 0 27  ARG A C     1 ? 
ATOM   229  O  O     . ARG A 1 27  ? -8.272  12.218  -12.471 1.000 23.248 0 27  ARG A O     1 ? 
ATOM   230  C  CB    . ARG A 1 27  ? -9.500  13.477  -9.621  1.000 18.799 0 27  ARG A CB    1 ? 
ATOM   231  C  CG    . ARG A 1 27  ? -10.040 13.004  -8.281  1.000 20.670 0 27  ARG A CG    1 ? 
ATOM   232  C  CD    . ARG A 1 27  ? -11.480 13.342  -8.031  1.000 21.020 0 27  ARG A CD    1 ? 
ATOM   233  N  NE    . ARG A 1 27  ? -11.715 14.782  -8.179  1.000 25.367 0 27  ARG A NE    1 ? 
ATOM   234  C  CZ    . ARG A 1 27  ? -11.519 15.697  -7.218  1.000 28.560 0 27  ARG A CZ    1 ? 
ATOM   235  N  NH1   . ARG A 1 27  ? -11.047 15.343  -6.022  1.000 24.890 0 27  ARG A NH1   1 ? 
ATOM   236  N  NH2   . ARG A 1 27  ? -11.785 16.975  -7.463  1.000 28.603 0 27  ARG A NH2   1 ? 
ATOM   237  N  N     . ASP A 1 28  ? -7.274  14.183  -11.812 1.000 22.672 0 28  ASP A N     1 ? 
ATOM   238  C  CA    . ASP A 1 28  ? -6.989  14.669  -13.195 1.000 23.807 0 28  ASP A CA    1 ? 
ATOM   239  C  C     . ASP A 1 28  ? -5.945  13.768  -13.848 1.000 25.825 0 28  ASP A C     1 ? 
ATOM   240  O  O     . ASP A 1 28  ? -6.166  13.364  -15.036 1.000 23.949 0 28  ASP A O     1 ? 
ATOM   241  C  CB    . ASP A 1 28  ? -6.591  16.149  -13.193 1.000 26.297 0 28  ASP A CB    1 ? 
ATOM   242  C  CG    . ASP A 1 28  ? -7.766  17.070  -12.943 1.000 25.155 0 28  ASP A CG    1 ? 
ATOM   243  O  OD1   . ASP A 1 28  ? -8.901  16.592  -12.997 1.000 31.218 0 28  ASP A OD1   1 ? 
ATOM   244  O  OD2   . ASP A 1 28  ? -7.525  18.254  -12.648 1.000 32.983 0 28  ASP A OD2   1 ? 
ATOM   245  N  N     . GLU A 1 29  ? -4.890  13.401  -13.115 1.000 21.091 0 29  GLU A N     1 ? 
ATOM   246  C  CA    . GLU A 1 29  ? -3.815  12.513  -13.583 1.000 22.736 0 29  GLU A CA    1 ? 
ATOM   247  C  C     . GLU A 1 29  ? -4.391  11.121  -13.851 1.000 22.554 0 29  GLU A C     1 ? 
ATOM   248  O  O     . GLU A 1 29  ? -4.049  10.530  -14.899 1.000 24.618 0 29  GLU A O     1 ? 
ATOM   249  C  CB    . GLU A 1 29  ? -2.686  12.475  -12.563 1.000 25.433 0 29  GLU A CB    1 ? 
ATOM   250  C  CG    . GLU A 1 29  ? -1.942  13.799  -12.485 1.000 27.929 0 29  GLU A CG    1 ? 
ATOM   251  C  CD    . GLU A 1 29  ? -1.072  14.025  -11.256 1.000 34.863 0 29  GLU A CD    1 ? 
ATOM   252  O  OE1   . GLU A 1 29  ? -0.256  14.969  -11.284 1.000 35.702 0 29  GLU A OE1   1 ? 
ATOM   253  O  OE2   . GLU A 1 29  ? -1.212  13.258  -10.272 1.000 39.198 0 29  GLU A OE2   1 ? 
ATOM   254  N  N     . ARG A 1 30  ? -5.258  10.619  -12.959 1.000 22.845 0 30  ARG A N     1 ? 
ATOM   255  C  CA    . ARG A 1 30  ? -5.943  9.310   -13.122 1.000 21.441 0 30  ARG A CA    1 ? 
ATOM   256  C  C     . ARG A 1 30  ? -6.726  9.335   -14.439 1.000 22.772 0 30  ARG A C     1 ? 
ATOM   257  O  O     . ARG A 1 30  ? -6.562  8.390   -15.270 1.000 21.544 0 30  ARG A O     1 ? 
ATOM   258  C  CB    . ARG A 1 30  ? -6.851  9.044   -11.921 1.000 20.399 0 30  ARG A CB    1 ? 
ATOM   259  C  CG    . ARG A 1 30  ? -7.749  7.818   -12.038 1.000 19.931 0 30  ARG A CG    1 ? 
ATOM   260  C  CD    . ARG A 1 30  ? -8.899  7.872   -11.069 1.000 18.924 0 30  ARG A CD    1 ? 
ATOM   261  N  NE    . ARG A 1 30  ? -9.785  8.959   -11.374 1.000 19.015 0 30  ARG A NE    1 ? 
ATOM   262  C  CZ    . ARG A 1 30  ? -10.629 9.525   -10.529 1.000 20.731 0 30  ARG A CZ    1 ? 
ATOM   263  N  NH1   . ARG A 1 30  ? -10.702 9.121   -9.268  1.000 21.617 0 30  ARG A NH1   1 ? 
ATOM   264  N  NH2   . ARG A 1 30  ? -11.365 10.544  -10.923 1.000 22.844 0 30  ARG A NH2   1 ? 
ATOM   265  N  N     . ASP A 1 31  ? -7.534  10.360  -14.600 1.000 21.441 0 31  ASP A N     1 ? 
ATOM   266  C  CA    . ASP A 1 31  ? -8.561  10.473  -15.663 1.000 24.453 0 31  ASP A CA    1 ? 
ATOM   267  C  C     . ASP A 1 31  ? -7.861  10.654  -17.016 1.000 27.378 0 31  ASP A C     1 ? 
ATOM   268  O  O     . ASP A 1 31  ? -8.387  10.119  -18.034 1.000 24.951 0 31  ASP A O     1 ? 
ATOM   269  C  CB    . ASP A 1 31  ? -9.530  11.607  -15.327 1.000 24.174 0 31  ASP A CB    1 ? 
ATOM   270  C  CG    . ASP A 1 31  ? -10.545 11.210  -14.272 1.000 27.256 0 31  ASP A CG    1 ? 
ATOM   271  O  OD1   . ASP A 1 31  ? -10.616 9.995   -13.956 1.000 28.958 0 31  ASP A OD1   1 ? 
ATOM   272  O  OD2   . ASP A 1 31  ? -11.291 12.103  -13.795 1.000 32.332 0 31  ASP A OD2   1 ? 
ATOM   273  N  N     . ALA A 1 32  ? -6.721  11.335  -17.039 1.000 25.871 0 32  ALA A N     1 ? 
ATOM   274  C  CA    . ALA A 1 32  ? -5.916  11.533  -18.268 1.000 28.058 0 32  ALA A CA    1 ? 
ATOM   275  C  C     . ALA A 1 32  ? -5.491  10.156  -18.794 1.000 28.768 0 32  ALA A C     1 ? 
ATOM   276  O  O     . ALA A 1 32  ? -5.597  9.915   -20.027 1.000 25.168 0 32  ALA A O     1 ? 
ATOM   277  C  CB    . ALA A 1 32  ? -4.727  12.414  -18.005 1.000 28.592 0 32  ALA A CB    1 ? 
ATOM   278  N  N     . VAL A 1 33  ? -5.090  9.249   -17.905 1.000 25.607 0 33  VAL A N     1 ? 
ATOM   279  C  CA    . VAL A 1 33  ? -4.631  7.891   -18.301 1.000 25.790 0 33  VAL A CA    1 ? 
ATOM   280  C  C     . VAL A 1 33  ? -5.830  7.065   -18.770 1.000 24.180 0 33  VAL A C     1 ? 
ATOM   281  O  O     . VAL A 1 33  ? -5.692  6.355   -19.813 1.000 23.827 0 33  VAL A O     1 ? 
ATOM   282  C  CB    . VAL A 1 33  ? -3.866  7.200   -17.173 1.000 24.715 0 33  VAL A CB    1 ? 
ATOM   283  C  CG1   . VAL A 1 33  ? -3.682  5.718   -17.456 1.000 25.356 0 33  VAL A CG1   1 ? 
ATOM   284  C  CG2   . VAL A 1 33  ? -2.535  7.878   -16.939 1.000 27.937 0 33  VAL A CG2   1 ? 
ATOM   285  N  N     . LEU A 1 34  ? -6.971  7.175   -18.108 1.000 22.340 0 34  LEU A N     1 ? 
ATOM   286  C  CA    . LEU A 1 34  ? -8.193  6.413   -18.486 1.000 23.110 0 34  LEU A CA    1 ? 
ATOM   287  C  C     . LEU A 1 34  ? -8.629  6.864   -19.886 1.000 23.990 0 34  LEU A C     1 ? 
ATOM   288  O  O     . LEU A 1 34  ? -9.031  5.983   -20.705 1.000 21.497 0 34  LEU A O     1 ? 
ATOM   289  C  CB    . LEU A 1 34  ? -9.303  6.635   -17.456 1.000 23.708 0 34  LEU A CB    1 ? 
ATOM   290  C  CG    . LEU A 1 34  ? -9.029  6.061   -16.052 1.000 22.406 0 34  LEU A CG    1 ? 
ATOM   291  C  CD1   . LEU A 1 34  ? -10.176 6.384   -15.115 1.000 23.206 0 34  LEU A CD1   1 ? 
ATOM   292  C  CD2   . LEU A 1 34  ? -8.801  4.553   -16.108 1.000 23.005 0 34  LEU A CD2   1 ? 
ATOM   293  N  N     . THR A 1 35  ? -8.510  8.164   -20.178 1.000 23.615 0 35  THR A N     1 ? 
ATOM   294  C  CA    . THR A 1 35  ? -8.851  8.753   -21.515 1.000 25.823 0 35  THR A CA    1 ? 
ATOM   295  C  C     . THR A 1 35  ? -7.859  8.215   -22.559 1.000 26.310 0 35  THR A C     1 ? 
ATOM   296  O  O     . THR A 1 35  ? -8.319  7.766   -23.649 1.000 25.069 0 35  THR A O     1 ? 
ATOM   297  C  CB    . THR A 1 35  ? -8.926  10.285  -21.445 1.000 26.782 0 35  THR A CB    1 ? 
ATOM   298  O  OG1   . THR A 1 35  ? -10.014 10.633  -20.591 1.000 28.328 0 35  THR A OG1   1 ? 
ATOM   299  C  CG2   . THR A 1 35  ? -9.155  10.935  -22.797 1.000 29.301 0 35  THR A CG2   1 ? 
ATOM   300  N  N     . ALA A 1 36  ? -6.567  8.210   -22.255 1.000 27.246 0 36  ALA A N     1 ? 
ATOM   301  C  CA    . ALA A 1 36  ? -5.528  7.679   -23.164 1.000 26.601 0 36  ALA A CA    1 ? 
ATOM   302  C  C     . ALA A 1 36  ? -5.809  6.190   -23.451 1.000 28.491 0 36  ALA A C     1 ? 
ATOM   303  O  O     . ALA A 1 36  ? -5.545  5.743   -24.601 1.000 30.721 0 36  ALA A O     1 ? 
ATOM   304  C  CB    . ALA A 1 36  ? -4.156  7.891   -22.590 1.000 28.046 0 36  ALA A CB    1 ? 
ATOM   305  N  N     . VAL A 1 37  ? -6.306  5.427   -22.475 1.000 24.425 0 37  VAL A N     1 ? 
ATOM   306  C  CA    . VAL A 1 37  ? -6.638  3.979   -22.683 1.000 25.549 0 37  VAL A CA    1 ? 
ATOM   307  C  C     . VAL A 1 37  ? -7.822  3.895   -23.671 1.000 28.467 0 37  VAL A C     1 ? 
ATOM   308  O  O     . VAL A 1 37  ? -7.762  3.057   -24.619 1.000 27.867 0 37  VAL A O     1 ? 
ATOM   309  C  CB    . VAL A 1 37  ? -6.954  3.227   -21.361 1.000 26.517 0 37  VAL A CB    1 ? 
ATOM   310  C  CG1   . VAL A 1 37  ? -7.474  1.819   -21.630 1.000 25.211 0 37  VAL A CG1   1 ? 
ATOM   311  C  CG2   . VAL A 1 37  ? -5.753  3.178   -20.416 1.000 26.331 0 37  VAL A CG2   1 ? 
ATOM   312  N  N     . ARG A 1 38  ? -8.875  4.686   -23.455 1.000 26.101 0 38  ARG A N     1 ? 
ATOM   313  C  CA    . ARG A 1 38  ? -10.090 4.655   -24.308 1.000 29.550 0 38  ARG A CA    1 ? 
ATOM   314  C  C     . ARG A 1 38  ? -9.698  5.004   -25.750 1.000 30.256 0 38  ARG A C     1 ? 
ATOM   315  O  O     . ARG A 1 38  ? -10.099 4.232   -26.685 1.000 27.227 0 38  ARG A O     1 ? 
ATOM   316  C  CB    . ARG A 1 38  ? -11.172 5.585   -23.759 1.000 30.391 0 38  ARG A CB    1 ? 
ATOM   317  C  CG    . ARG A 1 38  ? -11.910 4.992   -22.571 1.000 36.441 0 38  ARG A CG    1 ? 
ATOM   318  C  CD    . ARG A 1 38  ? -13.225 5.668   -22.229 1.000 40.388 0 38  ARG A CD    1 ? 
ATOM   319  N  NE    . ARG A 1 38  ? -13.480 5.499   -20.809 1.000 43.918 0 38  ARG A NE    1 ? 
ATOM   320  C  CZ    . ARG A 1 38  ? -12.927 6.249   -19.853 1.000 47.878 0 38  ARG A CZ    1 ? 
ATOM   321  N  NH1   . ARG A 1 38  ? -12.123 7.261   -20.177 1.000 42.203 0 38  ARG A NH1   1 ? 
ATOM   322  N  NH2   . ARG A 1 38  ? -13.188 5.988   -18.580 1.000 44.841 0 38  ARG A NH2   1 ? 
ATOM   323  N  N     . GLU A 1 39  ? -8.895  6.055   -25.935 1.000 31.336 0 39  GLU A N     1 ? 
ATOM   324  C  CA    . GLU A 1 39  ? -8.447  6.510   -27.273 1.000 32.302 0 39  GLU A CA    1 ? 
ATOM   325  C  C     . GLU A 1 39  ? -7.562  5.419   -27.879 1.000 33.845 0 39  GLU A C     1 ? 
ATOM   326  O  O     . GLU A 1 39  ? -7.813  5.047   -29.027 1.000 33.574 0 39  GLU A O     1 ? 
ATOM   327  C  CB    . GLU A 1 39  ? -7.694  7.844   -27.206 1.000 35.706 0 39  GLU A CB    1 ? 
ATOM   328  C  CG    . GLU A 1 39  ? -8.547  9.022   -26.746 1.000 39.234 0 39  GLU A CG    1 ? 
ATOM   329  C  CD    . GLU A 1 39  ? -9.911  9.169   -27.401 1.000 46.665 0 39  GLU A CD    1 ? 
ATOM   330  O  OE1   . GLU A 1 39  ? -10.820 9.707   -26.736 1.000 53.595 0 39  GLU A OE1   1 ? 
ATOM   331  O  OE2   . GLU A 1 39  ? -10.056 8.785   -28.589 1.000 48.441 0 39  GLU A OE2   1 ? 
ATOM   332  N  N     . GLY A 1 40  ? -6.583  4.923   -27.113 1.000 31.128 0 40  GLY A N     1 ? 
ATOM   333  C  CA    . GLY A 1 40  ? -5.571  3.941   -27.556 1.000 29.532 0 40  GLY A CA    1 ? 
ATOM   334  C  C     . GLY A 1 40  ? -6.196  2.629   -27.960 1.000 28.823 0 40  GLY A C     1 ? 
ATOM   335  O  O     . GLY A 1 40  ? -5.709  2.030   -28.947 1.000 32.195 0 40  GLY A O     1 ? 
ATOM   336  N  N     . LEU A 1 41  ? -7.266  2.215   -27.272 1.000 28.558 0 41  LEU A N     1 ? 
ATOM   337  C  CA    . LEU A 1 41  ? -8.006  0.948   -27.533 1.000 28.259 0 41  LEU A CA    1 ? 
ATOM   338  C  C     . LEU A 1 41  ? -8.676  1.012   -28.912 1.000 32.671 0 41  LEU A C     1 ? 
ATOM   339  O  O     . LEU A 1 41  ? -8.894  -0.070  -29.512 1.000 29.897 0 41  LEU A O     1 ? 
ATOM   340  C  CB    . LEU A 1 41  ? -9.046  0.701   -26.430 1.000 26.885 0 41  LEU A CB    1 ? 
ATOM   341  C  CG    . LEU A 1 41  ? -8.529  -0.010  -25.175 1.000 24.959 0 41  LEU A CG    1 ? 
ATOM   342  C  CD1   . LEU A 1 41  ? -9.650  -0.169  -24.159 1.000 26.344 0 41  LEU A CD1   1 ? 
ATOM   343  C  CD2   . LEU A 1 41  ? -7.927  -1.369  -25.518 1.000 24.820 0 41  LEU A CD2   1 ? 
ATOM   344  N  N     . LYS A 1 42  ? -9.055  2.210   -29.367 1.000 34.406 0 42  LYS A N     1 ? 
ATOM   345  C  CA    . LYS A 1 42  ? -9.669  2.395   -30.711 1.000 36.677 0 42  LYS A CA    1 ? 
ATOM   346  C  C     . LYS A 1 42  ? -8.671  1.906   -31.756 1.000 33.995 0 42  LYS A C     1 ? 
ATOM   347  O  O     . LYS A 1 42  ? -9.064  1.050   -32.574 1.000 34.476 0 42  LYS A O     1 ? 
ATOM   348  C  CB    . LYS A 1 42  ? -10.069 3.851   -30.958 1.000 39.873 0 42  LYS A CB    1 ? 
ATOM   349  C  CG    . LYS A 1 42  ? -11.289 4.317   -30.185 1.000 45.027 0 42  LYS A CG    1 ? 
ATOM   350  C  CD    . LYS A 1 42  ? -11.600 5.789   -30.391 1.000 49.843 0 42  LYS A CD    1 ? 
ATOM   351  C  CE    . LYS A 1 42  ? -12.510 6.363   -29.323 1.000 53.679 0 42  LYS A CE    1 ? 
ATOM   352  N  NZ    . LYS A 1 42  ? -12.728 7.815   -29.520 1.000 52.335 0 42  LYS A NZ    1 ? 
ATOM   353  N  N     . LYS A 1 43  ? -7.426  2.396   -31.694 1.000 34.273 0 43  LYS A N     1 ? 
ATOM   354  C  CA    . LYS A 1 43  ? -6.322  1.996   -32.605 1.000 40.017 0 43  LYS A CA    1 ? 
ATOM   355  C  C     . LYS A 1 43  ? -6.153  0.476   -32.526 1.000 39.239 0 43  LYS A C     1 ? 
ATOM   356  O  O     . LYS A 1 43  ? -6.161  -0.181  -33.585 1.000 39.178 0 43  LYS A O     1 ? 
ATOM   357  C  CB    . LYS A 1 43  ? -5.020  2.723   -32.248 1.000 45.463 0 43  LYS A CB    1 ? 
ATOM   358  C  CG    . LYS A 1 43  ? -3.879  2.548   -33.249 1.000 54.635 0 43  LYS A CG    1 ? 
ATOM   359  C  CD    . LYS A 1 43  ? -3.010  1.296   -33.034 1.000 64.307 0 43  LYS A CD    1 ? 
ATOM   360  C  CE    . LYS A 1 43  ? -2.367  1.212   -31.659 1.000 68.955 0 43  LYS A CE    1 ? 
ATOM   361  N  NZ    . LYS A 1 43  ? -1.399  2.312   -31.426 1.000 74.288 0 43  LYS A NZ    1 ? 
ATOM   362  N  N     . VAL A 1 44  ? -6.094  -0.077  -31.320 1.000 31.942 0 44  VAL A N     1 ? 
ATOM   363  C  CA    . VAL A 1 44  ? -5.791  -1.522  -31.125 1.000 32.108 0 44  VAL A CA    1 ? 
ATOM   364  C  C     . VAL A 1 44  ? -6.880  -2.360  -31.797 1.000 32.338 0 44  VAL A C     1 ? 
ATOM   365  O  O     . VAL A 1 44  ? -6.532  -3.379  -32.402 1.000 34.150 0 44  VAL A O     1 ? 
ATOM   366  C  CB    . VAL A 1 44  ? -5.629  -1.889  -29.640 1.000 29.360 0 44  VAL A CB    1 ? 
ATOM   367  C  CG1   . VAL A 1 44  ? -5.516  -3.395  -29.453 1.000 29.928 0 44  VAL A CG1   1 ? 
ATOM   368  C  CG2   . VAL A 1 44  ? -4.439  -1.181  -29.018 1.000 29.616 0 44  VAL A CG2   1 ? 
ATOM   369  N  N     . PHE A 1 45  ? -8.145  -1.949  -31.712 1.000 31.909 0 45  PHE A N     1 ? 
ATOM   370  C  CA    . PHE A 1 45  ? -9.295  -2.754  -32.180 1.000 33.267 0 45  PHE A CA    1 ? 
ATOM   371  C  C     . PHE A 1 45  ? -9.673  -2.365  -33.615 1.000 32.944 0 45  PHE A C     1 ? 
ATOM   372  O  O     . PHE A 1 45  ? -10.568 -3.011  -34.165 1.000 33.441 0 45  PHE A O     1 ? 
ATOM   373  C  CB    . PHE A 1 45  ? -10.442 -2.685  -31.178 1.000 32.690 0 45  PHE A CB    1 ? 
ATOM   374  C  CG    . PHE A 1 45  ? -10.278 -3.711  -30.101 1.000 32.282 0 45  PHE A CG    1 ? 
ATOM   375  C  CD1   . PHE A 1 45  ? -9.311  -3.541  -29.114 1.000 31.017 0 45  PHE A CD1   1 ? 
ATOM   376  C  CD2   . PHE A 1 45  ? -10.948 -4.921  -30.171 1.000 31.169 0 45  PHE A CD2   1 ? 
ATOM   377  C  CE1   . PHE A 1 45  ? -9.101  -4.523  -28.165 1.000 31.168 0 45  PHE A CE1   1 ? 
ATOM   378  C  CE2   . PHE A 1 45  ? -10.718 -5.909  -29.233 1.000 31.522 0 45  PHE A CE2   1 ? 
ATOM   379  C  CZ    . PHE A 1 45  ? -9.801  -5.704  -28.224 1.000 33.108 0 45  PHE A CZ    1 ? 
ATOM   380  N  N     . ALA A 1 46  ? -8.932  -1.429  -34.218 1.000 38.962 0 46  ALA A N     1 ? 
ATOM   381  C  CA    . ALA A 1 46  ? -9.116  -0.975  -35.616 1.000 38.245 0 46  ALA A CA    1 ? 
ATOM   382  C  C     . ALA A 1 46  ? -8.841  -2.146  -36.565 1.000 37.874 0 46  ALA A C     1 ? 
ATOM   383  O  O     . ALA A 1 46  ? -9.520  -2.239  -37.606 1.000 32.366 0 46  ALA A O     1 ? 
ATOM   384  C  CB    . ALA A 1 46  ? -8.209  0.195   -35.908 1.000 39.067 0 46  ALA A CB    1 ? 
ATOM   385  N  N     . ASP A 1 47  ? -7.899  -3.031  -36.218 1.000 35.512 0 47  ASP A N     1 ? 
ATOM   386  C  CA    . ASP A 1 47  ? -7.514  -4.152  -37.114 1.000 36.922 0 47  ASP A CA    1 ? 
ATOM   387  C  C     . ASP A 1 47  ? -8.143  -5.463  -36.614 1.000 34.697 0 47  ASP A C     1 ? 
ATOM   388  O  O     . ASP A 1 47  ? -7.817  -6.501  -37.179 1.000 30.468 0 47  ASP A O     1 ? 
ATOM   389  C  CB    . ASP A 1 47  ? -5.990  -4.228  -37.292 1.000 43.146 0 47  ASP A CB    1 ? 
ATOM   390  C  CG    . ASP A 1 47  ? -5.494  -3.463  -38.514 1.000 45.619 0 47  ASP A CG    1 ? 
ATOM   391  O  OD1   . ASP A 1 47  ? -4.441  -2.794  -38.402 1.000 52.723 0 47  ASP A OD1   1 ? 
ATOM   392  O  OD2   . ASP A 1 47  ? -6.163  -3.562  -39.593 1.000 49.642 0 47  ASP A OD2   1 ? 
ATOM   393  N  N     . ARG A 1 48  ? -9.126  -5.401  -35.712 1.000 28.377 0 48  ARG A N     1 ? 
ATOM   394  C  CA    . ARG A 1 48  ? -9.814  -6.611  -35.186 1.000 29.414 0 48  ARG A CA    1 ? 
ATOM   395  C  C     . ARG A 1 48  ? -11.231 -6.687  -35.776 1.000 23.494 0 48  ARG A C     1 ? 
ATOM   396  O  O     . ARG A 1 48  ? -11.880 -7.758  -35.644 1.000 20.480 0 48  ARG A O     1 ? 
ATOM   397  C  CB    . ARG A 1 48  ? -9.784  -6.590  -33.659 1.000 35.573 0 48  ARG A CB    1 ? 
ATOM   398  C  CG    . ARG A 1 48  ? -8.371  -6.674  -33.098 1.000 42.219 0 48  ARG A CG    1 ? 
ATOM   399  C  CD    . ARG A 1 48  ? -8.323  -6.817  -31.586 1.000 45.986 0 48  ARG A CD    1 ? 
ATOM   400  N  NE    . ARG A 1 48  ? -9.031  -8.006  -31.103 1.000 48.159 0 48  ARG A NE    1 ? 
ATOM   401  C  CZ    . ARG A 1 48  ? -8.484  -8.989  -30.383 1.000 42.337 0 48  ARG A CZ    1 ? 
ATOM   402  N  NH1   . ARG A 1 48  ? -9.233  -10.001 -29.991 1.000 42.347 0 48  ARG A NH1   1 ? 
ATOM   403  N  NH2   . ARG A 1 48  ? -7.197  -8.967  -30.075 1.000 47.583 0 48  ARG A NH2   1 ? 
ATOM   404  N  N     . GLY A 1 49  ? -11.698 -5.589  -36.351 1.000 26.045 0 49  GLY A N     1 ? 
ATOM   405  C  CA    . GLY A 1 49  ? -12.960 -5.512  -37.108 1.000 27.815 0 49  GLY A CA    1 ? 
ATOM   406  C  C     . GLY A 1 49  ? -14.157 -5.291  -36.208 1.000 28.349 0 49  GLY A C     1 ? 
ATOM   407  O  O     . GLY A 1 49  ? -15.281 -5.635  -36.610 1.000 27.711 0 49  GLY A O     1 ? 
ATOM   408  N  N     . GLU A 1 50  ? -13.938 -4.737  -35.016 1.000 26.273 0 50  GLU A N     1 ? 
ATOM   409  C  CA    . GLU A 1 50  ? -15.031 -4.462  -34.061 1.000 26.443 0 50  GLU A CA    1 ? 
ATOM   410  C  C     . GLU A 1 50  ? -14.633 -3.304  -33.147 1.000 27.932 0 50  GLU A C     1 ? 
ATOM   411  O  O     . GLU A 1 50  ? -13.443 -2.909  -33.145 1.000 28.098 0 50  GLU A O     1 ? 
ATOM   412  C  CB    . GLU A 1 50  ? -15.341 -5.715  -33.269 1.000 26.622 0 50  GLU A CB    1 ? 
ATOM   413  C  CG    . GLU A 1 50  ? -14.139 -6.251  -32.517 1.000 27.013 0 50  GLU A CG    1 ? 
ATOM   414  C  CD    . GLU A 1 50  ? -14.413 -7.515  -31.734 1.000 29.923 0 50  GLU A CD    1 ? 
ATOM   415  O  OE1   . GLU A 1 50  ? -13.457 -8.270  -31.502 1.000 33.246 0 50  GLU A OE1   1 ? 
ATOM   416  O  OE2   . GLU A 1 50  ? -15.585 -7.732  -31.360 1.000 35.728 0 50  GLU A OE2   1 ? 
ATOM   417  N  N     . ALA A 1 51  ? -15.618 -2.717  -32.489 1.000 28.790 0 51  ALA A N     1 ? 
ATOM   418  C  CA    . ALA A 1 51  ? -15.420 -1.661  -31.474 1.000 29.097 0 51  ALA A CA    1 ? 
ATOM   419  C  C     . ALA A 1 51  ? -14.529 -2.230  -30.373 1.000 31.485 0 51  ALA A C     1 ? 
ATOM   420  O  O     . ALA A 1 51  ? -14.674 -3.427  -30.056 1.000 26.574 0 51  ALA A O     1 ? 
ATOM   421  C  CB    . ALA A 1 51  ? -16.752 -1.208  -30.935 1.000 30.167 0 51  ALA A CB    1 ? 
ATOM   422  N  N     . ALA A 1 52  ? -13.626 -1.412  -29.835 1.000 31.393 0 52  ALA A N     1 ? 
ATOM   423  C  CA    . ALA A 1 52  ? -12.909 -1.693  -28.570 1.000 32.423 0 52  ALA A CA    1 ? 
ATOM   424  C  C     . ALA A 1 52  ? -13.917 -2.077  -27.492 1.000 30.475 0 52  ALA A C     1 ? 
ATOM   425  O  O     . ALA A 1 52  ? -15.027 -1.545  -27.439 1.000 27.181 0 52  ALA A O     1 ? 
ATOM   426  C  CB    . ALA A 1 52  ? -12.100 -0.487  -28.169 1.000 31.137 0 52  ALA A CB    1 ? 
ATOM   427  N  N     . PRO A 1 53  ? -13.576 -3.023  -26.596 1.000 28.678 0 53  PRO A N     1 ? 
ATOM   428  C  CA    . PRO A 1 53  ? -14.421 -3.311  -25.443 1.000 29.803 0 53  PRO A CA    1 ? 
ATOM   429  C  C     . PRO A 1 53  ? -14.489 -2.074  -24.540 1.000 26.230 0 53  PRO A C     1 ? 
ATOM   430  O  O     . PRO A 1 53  ? -13.510 -1.344  -24.478 1.000 26.148 0 53  PRO A O     1 ? 
ATOM   431  C  CB    . PRO A 1 53  ? -13.702 -4.481  -24.743 1.000 33.390 0 53  PRO A CB    1 ? 
ATOM   432  C  CG    . PRO A 1 53  ? -12.247 -4.302  -25.139 1.000 33.919 0 53  PRO A CG    1 ? 
ATOM   433  C  CD    . PRO A 1 53  ? -12.284 -3.720  -26.538 1.000 31.638 0 53  PRO A CD    1 ? 
ATOM   434  N  N     . THR A 1 54  ? -15.640 -1.815  -23.934 1.000 24.323 0 54  THR A N     1 ? 
ATOM   435  C  CA    . THR A 1 54  ? -15.782 -0.722  -22.947 1.000 26.367 0 54  THR A CA    1 ? 
ATOM   436  C  C     . THR A 1 54  ? -15.228 -1.215  -21.604 1.000 25.004 0 54  THR A C     1 ? 
ATOM   437  O  O     . THR A 1 54  ? -15.083 -2.433  -21.425 1.000 24.986 0 54  THR A O     1 ? 
ATOM   438  C  CB    . THR A 1 54  ? -17.231 -0.245  -22.845 1.000 26.747 0 54  THR A CB    1 ? 
ATOM   439  O  OG1   . THR A 1 54  ? -18.047 -1.331  -22.411 1.000 27.867 0 54  THR A OG1   1 ? 
ATOM   440  C  CG2   . THR A 1 54  ? -17.747 0.321   -24.149 1.000 29.171 0 54  THR A CG2   1 ? 
ATOM   441  N  N     . PHE A 1 55  ? -14.961 -0.301  -20.674 1.000 23.959 0 55  PHE A N     1 ? 
ATOM   442  C  CA    . PHE A 1 55  ? -14.542 -0.665  -19.300 1.000 21.998 0 55  PHE A CA    1 ? 
ATOM   443  C  C     . PHE A 1 55  ? -15.146 0.301   -18.296 1.000 21.802 0 55  PHE A C     1 ? 
ATOM   444  O  O     . PHE A 1 55  ? -15.383 1.465   -18.641 1.000 21.369 0 55  PHE A O     1 ? 
ATOM   445  C  CB    . PHE A 1 55  ? -13.014 -0.714  -19.180 1.000 21.805 0 55  PHE A CB    1 ? 
ATOM   446  C  CG    . PHE A 1 55  ? -12.297 0.597   -19.369 1.000 21.181 0 55  PHE A CG    1 ? 
ATOM   447  C  CD1   . PHE A 1 55  ? -12.216 1.521   -18.335 1.000 20.756 0 55  PHE A CD1   1 ? 
ATOM   448  C  CD2   . PHE A 1 55  ? -11.619 0.871   -20.543 1.000 20.886 0 55  PHE A CD2   1 ? 
ATOM   449  C  CE1   . PHE A 1 55  ? -11.539 2.717   -18.509 1.000 23.227 0 55  PHE A CE1   1 ? 
ATOM   450  C  CE2   . PHE A 1 55  ? -10.951 2.070   -20.720 1.000 24.092 0 55  PHE A CE2   1 ? 
ATOM   451  C  CZ    . PHE A 1 55  ? -10.887 2.987   -19.689 1.000 22.536 0 55  PHE A CZ    1 ? 
ATOM   452  N  N     . THR A 1 56  ? -15.292 -0.182  -17.066 1.000 20.621 0 56  THR A N     1 ? 
ATOM   453  C  CA    . THR A 1 56  ? -15.747 0.580   -15.860 1.000 20.390 0 56  THR A CA    1 ? 
ATOM   454  C  C     . THR A 1 56  ? -14.529 0.751   -14.959 1.000 18.031 0 56  THR A C     1 ? 
ATOM   455  O  O     . THR A 1 56  ? -13.964 -0.259  -14.544 1.000 19.216 0 56  THR A O     1 ? 
ATOM   456  C  CB    . THR A 1 56  ? -16.857 -0.179  -15.133 1.000 21.541 0 56  THR A CB    1 ? 
ATOM   457  O  OG1   . THR A 1 56  ? -17.941 -0.298  -16.059 1.000 26.988 0 56  THR A OG1   1 ? 
ATOM   458  C  CG2   . THR A 1 56  ? -17.356 0.522   -13.881 1.000 23.861 0 56  THR A CG2   1 ? 
ATOM   459  N  N     . PRO A 1 57  ? -14.025 1.991   -14.748 1.000 18.622 0 57  PRO A N     1 ? 
ATOM   460  C  CA    . PRO A 1 57  ? -12.903 2.228   -13.839 1.000 17.904 0 57  PRO A CA    1 ? 
ATOM   461  C  C     . PRO A 1 57  ? -13.380 2.396   -12.391 1.000 17.565 0 57  PRO A C     1 ? 
ATOM   462  O  O     . PRO A 1 57  ? -14.490 2.753   -12.159 1.000 17.789 0 57  PRO A O     1 ? 
ATOM   463  C  CB    . PRO A 1 57  ? -12.324 3.524   -14.397 1.000 18.431 0 57  PRO A CB    1 ? 
ATOM   464  C  CG    . PRO A 1 57  ? -13.575 4.308   -14.746 1.000 17.885 0 57  PRO A CG    1 ? 
ATOM   465  C  CD    . PRO A 1 57  ? -14.488 3.252   -15.361 1.000 19.865 0 57  PRO A CD    1 ? 
ATOM   466  N  N     . PHE A 1 58  ? -12.537 2.042   -11.451 1.000 15.251 0 58  PHE A N     1 ? 
ATOM   467  C  CA    . PHE A 1 58  ? -12.796 2.299   -10.017 1.000 14.895 0 58  PHE A CA    1 ? 
ATOM   468  C  C     . PHE A 1 58  ? -11.464 2.590   -9.327  1.000 13.674 0 58  PHE A C     1 ? 
ATOM   469  O  O     . PHE A 1 58  ? -10.402 2.127   -9.744  1.000 13.822 0 58  PHE A O     1 ? 
ATOM   470  C  CB    . PHE A 1 58  ? -13.587 1.144   -9.390  1.000 13.635 0 58  PHE A CB    1 ? 
ATOM   471  C  CG    . PHE A 1 58  ? -12.879 -0.161  -9.331  1.000 14.323 0 58  PHE A CG    1 ? 
ATOM   472  C  CD1   . PHE A 1 58  ? -12.866 -1.024  -10.436 1.000 16.406 0 58  PHE A CD1   1 ? 
ATOM   473  C  CD2   . PHE A 1 58  ? -12.213 -0.558  -8.191  1.000 15.118 0 58  PHE A CD2   1 ? 
ATOM   474  C  CE1   . PHE A 1 58  ? -12.205 -2.230  -10.370 1.000 15.843 0 58  PHE A CE1   1 ? 
ATOM   475  C  CE2   . PHE A 1 58  ? -11.607 -1.804  -8.121  1.000 15.157 0 58  PHE A CE2   1 ? 
ATOM   476  C  CZ    . PHE A 1 58  ? -11.572 -2.618  -9.224  1.000 15.152 0 58  PHE A CZ    1 ? 
ATOM   477  N  N     . ASN A 1 59  ? -11.512 3.454   -8.311  1.000 13.070 0 59  ASN A N     1 ? 
ATOM   478  C  CA    . ASN A 1 59  ? -10.350 3.829   -7.491  1.000 12.792 0 59  ASN A CA    1 ? 
ATOM   479  C  C     . ASN A 1 59  ? -9.868  2.640   -6.652  1.000 10.821 0 59  ASN A C     1 ? 
ATOM   480  O  O     . ASN A 1 59  ? -10.694 1.849   -6.184  1.000 12.414 0 59  ASN A O     1 ? 
ATOM   481  C  CB    . ASN A 1 59  ? -10.718 4.965   -6.561  1.000 12.611 0 59  ASN A CB    1 ? 
ATOM   482  C  CG    . ASN A 1 59  ? -10.964 6.247   -7.299  1.000 15.011 0 59  ASN A CG    1 ? 
ATOM   483  O  OD1   . ASN A 1 59  ? -10.436 6.447   -8.375  1.000 16.095 0 59  ASN A OD1   1 ? 
ATOM   484  N  ND2   . ASN A 1 59  ? -11.681 7.141   -6.683  1.000 16.509 0 59  ASN A ND2   1 ? 
ATOM   485  N  N     . GLN A 1 60  ? -8.569  2.494   -6.548  1.000 11.851 0 60  GLN A N     1 ? 
ATOM   486  C  CA    . GLN A 1 60  ? -7.936  1.403   -5.768  1.000 12.521 0 60  GLN A CA    1 ? 
ATOM   487  C  C     . GLN A 1 60  ? -6.813  1.973   -4.949  1.000 11.193 0 60  GLN A C     1 ? 
ATOM   488  O  O     . GLN A 1 60  ? -6.431  3.130   -5.174  1.000 11.768 0 60  GLN A O     1 ? 
ATOM   489  C  CB    . GLN A 1 60  ? -7.307  0.319   -6.654  1.000 15.864 0 60  GLN A CB    1 ? 
ATOM   490  C  CG    . GLN A 1 60  ? -8.303  -0.534  -7.366  1.000 18.772 0 60  GLN A CG    1 ? 
ATOM   491  C  CD    . GLN A 1 60  ? -7.620  -1.680  -8.054  1.000 19.216 0 60  GLN A CD    1 ? 
ATOM   492  O  OE1   . GLN A 1 60  ? -6.414  -1.687  -8.263  1.000 25.109 0 60  GLN A OE1   1 ? 
ATOM   493  N  NE2   . GLN A 1 60  ? -8.400  -2.586  -8.550  1.000 21.807 0 60  GLN A NE2   1 ? 
ATOM   494  N  N     . GLY A 1 61  ? -6.318  1.190   -4.026  1.000 10.669 0 61  GLY A N     1 ? 
ATOM   495  C  CA    . GLY A 1 61  ? -5.070  1.516   -3.370  1.000 9.438  0 61  GLY A CA    1 ? 
ATOM   496  C  C     . GLY A 1 61  ? -5.211  2.593   -2.304  1.000 8.657  0 61  GLY A C     1 ? 
ATOM   497  O  O     . GLY A 1 61  ? -6.345  2.986   -1.923  1.000 9.175  0 61  GLY A O     1 ? 
ATOM   498  N  N     . SER A 1 62  ? -4.095  3.123   -1.884  1.000 8.940  0 62  SER A N     1 ? 
ATOM   499  C  CA    . SER A 1 62  ? -4.041  4.018   -0.703  1.000 9.785  0 62  SER A CA    1 ? 
ATOM   500  C  C     . SER A 1 62  ? -4.789  5.320   -0.987  1.000 9.562  0 62  SER A C     1 ? 
ATOM   501  O  O     . SER A 1 62  ? -5.383  5.876   -0.066  1.000 9.026  0 62  SER A O     1 ? 
ATOM   502  C  CB    . SER A 1 62  ? -2.644  4.282   -0.296  1.000 10.942 0 62  SER A CB    1 ? 
ATOM   503  O  OG    . SER A 1 62  ? -1.908  4.927   -1.302  1.000 11.237 0 62  SER A OG    1 ? 
ATOM   504  N  N     . TYR A 1 63  ? -4.842  5.779   -2.239  1.000 10.378 0 63  TYR A N     1 ? 
ATOM   505  C  CA    . TYR A 1 63  ? -5.532  7.037   -2.552  1.000 10.248 0 63  TYR A CA    1 ? 
ATOM   506  C  C     . TYR A 1 63  ? -7.031  6.840   -2.489  1.000 9.792  0 63  TYR A C     1 ? 
ATOM   507  O  O     . TYR A 1 63  ? -7.725  7.825   -2.297  1.000 10.867 0 63  TYR A O     1 ? 
ATOM   508  C  CB    . TYR A 1 63  ? -5.008  7.564   -3.895  1.000 11.417 0 63  TYR A CB    1 ? 
ATOM   509  C  CG    . TYR A 1 63  ? -3.509  7.755   -4.007  1.000 12.017 0 63  TYR A CG    1 ? 
ATOM   510  C  CD1   . TYR A 1 63  ? -2.944  8.087   -5.230  1.000 14.220 0 63  TYR A CD1   1 ? 
ATOM   511  C  CD2   . TYR A 1 63  ? -2.627  7.623   -2.934  1.000 13.208 0 63  TYR A CD2   1 ? 
ATOM   512  C  CE1   . TYR A 1 63  ? -1.589  8.291   -5.390  1.000 14.627 0 63  TYR A CE1   1 ? 
ATOM   513  C  CE2   . TYR A 1 63  ? -1.266  7.867   -3.073  1.000 14.511 0 63  TYR A CE2   1 ? 
ATOM   514  C  CZ    . TYR A 1 63  ? -0.738  8.158   -4.322  1.000 13.718 0 63  TYR A CZ    1 ? 
ATOM   515  O  OH    . TYR A 1 63  ? 0.614   8.383   -4.514  1.000 14.936 0 63  TYR A OH    1 ? 
ATOM   516  N  N     . ALA A 1 64  ? -7.546  5.604   -2.598  1.000 8.753  0 64  ALA A N     1 ? 
ATOM   517  C  CA    . ALA A 1 64  ? -8.972  5.290   -2.378  1.000 9.149  0 64  ALA A CA    1 ? 
ATOM   518  C  C     . ALA A 1 64  ? -9.279  5.134   -0.888  1.000 9.376  0 64  ALA A C     1 ? 
ATOM   519  O  O     . ALA A 1 64  ? -10.405 5.331   -0.488  1.000 12.039 0 64  ALA A O     1 ? 
ATOM   520  C  CB    . ALA A 1 64  ? -9.379  4.049   -3.168  1.000 9.853  0 64  ALA A CB    1 ? 
ATOM   521  N  N     . MET A 1 65  ? -8.298  4.671   -0.115  1.000 9.948  0 65  MET A N     1 ? 
ATOM   522  C  CA    . MET A 1 65  ? -8.510  4.275   1.292   1.000 9.930  0 65  MET A CA    1 ? 
ATOM   523  C  C     . MET A 1 65  ? -8.092  5.395   2.255   1.000 8.735  0 65  MET A C     1 ? 
ATOM   524  O  O     . MET A 1 65  ? -8.232  5.195   3.516   1.000 8.719  0 65  MET A O     1 ? 
ATOM   525  C  CB    . MET A 1 65  ? -7.733  2.988   1.597   1.000 9.763  0 65  MET A CB    1 ? 
ATOM   526  C  CG    . MET A 1 65  ? -8.178  1.808   0.781   1.000 12.123 0 65  MET A CG    1 ? 
ATOM   527  S  SD    . MET A 1 65  ? -7.460  0.256   1.248   1.000 13.055 0 65  MET A SD    1 ? 
ATOM   528  C  CE    . MET A 1 65  ? -5.795  0.501   0.681   1.000 18.040 0 65  MET A CE    1 ? 
ATOM   529  N  N     . ASN A 1 66  ? -7.627  6.536   1.769   1.000 8.291  0 66  ASN A N     1 ? 
ATOM   530  C  CA    . ASN A 1 66  ? -7.227  7.661   2.649   1.000 8.512  0 66  ASN A CA    1 ? 
ATOM   531  C  C     . ASN A 1 66  ? -6.038  7.244   3.536   1.000 8.822  0 66  ASN A C     1 ? 
ATOM   532  O  O     . ASN A 1 66  ? -5.988  7.602   4.724   1.000 8.054  0 66  ASN A O     1 ? 
ATOM   533  C  CB    . ASN A 1 66  ? -8.400  8.163   3.468   1.000 9.089  0 66  ASN A CB    1 ? 
ATOM   534  C  CG    . ASN A 1 66  ? -8.218  9.559   3.962   1.000 10.833 0 66  ASN A CG    1 ? 
ATOM   535  O  OD1   . ASN A 1 66  ? -7.261  10.247  3.575   1.000 11.252 0 66  ASN A OD1   1 ? 
ATOM   536  N  ND2   . ASN A 1 66  ? -9.075  9.944   4.890   1.000 12.275 0 66  ASN A ND2   1 ? 
ATOM   537  N  N     . THR A 1 67  ? -5.092  6.520   2.961   1.000 7.917  0 67  THR A N     1 ? 
ATOM   538  C  CA    . THR A 1 67  ? -3.857  6.090   3.627   1.000 7.684  0 67  THR A CA    1 ? 
ATOM   539  C  C     . THR A 1 67  ? -2.647  6.481   2.804   1.000 7.639  0 67  THR A C     1 ? 
ATOM   540  O  O     . THR A 1 67  ? -1.559  5.958   3.084   1.000 8.212  0 67  THR A O     1 ? 
ATOM   541  C  CB    . THR A 1 67  ? -3.885  4.599   3.903   1.000 7.895  0 67  THR A CB    1 ? 
ATOM   542  O  OG1   . THR A 1 67  ? -4.073  3.959   2.637   1.000 8.149  0 67  THR A OG1   1 ? 
ATOM   543  C  CG2   . THR A 1 67  ? -4.997  4.207   4.861   1.000 9.057  0 67  THR A CG2   1 ? 
ATOM   544  N  N     . GLY A 1 68  ? -2.798  7.430   1.889   1.000 7.972  0 68  GLY A N     1 ? 
ATOM   545  C  CA    . GLY A 1 68  ? -1.689  7.822   1.035   1.000 8.100  0 68  GLY A CA    1 ? 
ATOM   546  C  C     . GLY A 1 68  ? -0.708  8.724   1.756   1.000 7.657  0 68  GLY A C     1 ? 
ATOM   547  O  O     . GLY A 1 68  ? -1.146  9.556   2.586   1.000 7.671  0 68  GLY A O     1 ? 
ATOM   548  N  N     . VAL A 1 69  ? 0.543   8.619   1.383   1.000 7.790  0 69  VAL A N     1 ? 
ATOM   549  C  CA    . VAL A 1 69  ? 1.597   9.553   1.867   1.000 8.826  0 69  VAL A CA    1 ? 
ATOM   550  C  C     . VAL A 1 69  ? 2.254   10.254  0.686   1.000 9.366  0 69  VAL A C     1 ? 
ATOM   551  O  O     . VAL A 1 69  ? 2.295   9.725   -0.437  1.000 10.441 0 69  VAL A O     1 ? 
ATOM   552  C  CB    . VAL A 1 69  ? 2.666   8.849   2.696   1.000 9.796  0 69  VAL A CB    1 ? 
ATOM   553  C  CG1   . VAL A 1 69  ? 2.065   8.310   3.987   1.000 10.277 0 69  VAL A CG1   1 ? 
ATOM   554  C  CG2   . VAL A 1 69  ? 3.378   7.770   1.984   1.000 11.243 0 69  VAL A CG2   1 ? 
ATOM   555  N  N     . LYS A 1 70  ? 2.752   11.427  0.954   1.000 8.826  0 70  LYS A N     1 ? 
ATOM   556  C  CA    . LYS A 1 70  ? 3.620   12.134  0.018   1.000 8.985  0 70  LYS A CA    1 ? 
ATOM   557  C  C     . LYS A 1 70  ? 4.911   11.378  -0.105  1.000 9.075  0 70  LYS A C     1 ? 
ATOM   558  O  O     . LYS A 1 70  ? 5.530   11.031  0.886   1.000 9.018  0 70  LYS A O     1 ? 
ATOM   559  C  CB    . LYS A 1 70  ? 3.819   13.568  0.501   1.000 8.566  0 70  LYS A CB    1 ? 
ATOM   560  C  CG    . LYS A 1 70  ? 2.562   14.413  0.461   1.000 9.677  0 70  LYS A CG    1 ? 
ATOM   561  C  CD    . LYS A 1 70  ? 2.735   15.746  1.126   1.000 10.431 0 70  LYS A CD    1 ? 
ATOM   562  C  CE    . LYS A 1 70  ? 1.629   16.679  0.767   1.000 10.757 0 70  LYS A CE    1 ? 
ATOM   563  N  NZ    . LYS A 1 70  ? 1.744   17.932  1.538   1.000 11.648 0 70  LYS A NZ    1 ? 
ATOM   564  N  N     . PRO A 1 71  ? 5.453   11.276  -1.331  1.000 10.255 0 71  PRO A N     1 ? 
ATOM   565  C  CA    . PRO A 1 71  ? 6.773   10.727  -1.507  1.000 11.560 0 71  PRO A CA    1 ? 
ATOM   566  C  C     . PRO A 1 71  ? 7.869   11.645  -0.984  1.000 12.294 0 71  PRO A C     1 ? 
ATOM   567  O  O     . PRO A 1 71  ? 7.655   12.842  -0.948  1.000 12.480 0 71  PRO A O     1 ? 
ATOM   568  C  CB    . PRO A 1 71  ? 6.904   10.540  -3.014  1.000 12.205 0 71  PRO A CB    1 ? 
ATOM   569  C  CG    . PRO A 1 71  ? 5.820   11.389  -3.629  1.000 16.173 0 71  PRO A CG    1 ? 
ATOM   570  C  CD    . PRO A 1 71  ? 4.763   11.599  -2.562  1.000 12.372 0 71  PRO A CD    1 ? 
ATOM   571  N  N     . LEU A 1 72  ? 8.976   11.057  -0.583  1.000 13.869 0 72  LEU A N     1 ? 
ATOM   572  C  CA    . LEU A 1 72  ? 10.233  11.787  -0.343  1.000 14.859 0 72  LEU A CA    1 ? 
ATOM   573  C  C     . LEU A 1 72  ? 10.726  12.342  -1.683  1.000 18.889 0 72  LEU A C     1 ? 
ATOM   574  O  O     . LEU A 1 72  ? 10.293  11.855  -2.773  1.000 16.614 0 72  LEU A O     1 ? 
ATOM   575  C  CB    . LEU A 1 72  ? 11.248  10.854  0.333   1.000 15.360 0 72  LEU A CB    1 ? 
ATOM   576  C  CG    . LEU A 1 72  ? 10.878  10.418  1.765   1.000 14.716 0 72  LEU A CG    1 ? 
ATOM   577  C  CD1   . LEU A 1 72  ? 11.870  9.412   2.302   1.000 15.974 0 72  LEU A CD1   1 ? 
ATOM   578  C  CD2   . LEU A 1 72  ? 10.781  11.572  2.708   1.000 14.829 0 72  LEU A CD2   1 ? 
ATOM   579  N  N     . GLU A 1 73  ? 11.605  13.326  -1.630  1.000 20.688 0 73  GLU A N     1 ? 
ATOM   580  C  CA    . GLU A 1 73  ? 12.215  13.911  -2.860  1.000 24.530 0 73  GLU A CA    1 ? 
ATOM   581  C  C     . GLU A 1 73  ? 12.752  12.786  -3.737  1.000 21.259 0 73  GLU A C     1 ? 
ATOM   582  O  O     . GLU A 1 73  ? 13.458  11.943  -3.228  1.000 23.471 0 73  GLU A O     1 ? 
ATOM   583  C  CB    . GLU A 1 73  ? 13.327  14.874  -2.488  1.000 29.305 0 73  GLU A CB    1 ? 
ATOM   584  C  CG    . GLU A 1 73  ? 13.742  15.771  -3.643  1.000 35.357 0 73  GLU A CG    1 ? 
ATOM   585  C  CD    . GLU A 1 73  ? 14.766  16.823  -3.267  1.000 43.839 0 73  GLU A CD    1 ? 
ATOM   586  O  OE1   . GLU A 1 73  ? 15.667  16.500  -2.453  1.000 43.303 0 73  GLU A OE1   1 ? 
ATOM   587  O  OE2   . GLU A 1 73  ? 14.643  17.977  -3.764  1.000 51.997 0 73  GLU A OE2   1 ? 
ATOM   588  N  N     . GLY A 1 74  ? 12.443  12.811  -5.029  1.000 25.372 0 74  GLY A N     1 ? 
ATOM   589  C  CA    . GLY A 1 74  ? 12.941  11.815  -5.997  1.000 27.591 0 74  GLY A CA    1 ? 
ATOM   590  C  C     . GLY A 1 74  ? 12.086  10.554  -6.014  1.000 30.707 0 74  GLY A C     1 ? 
ATOM   591  O  O     . GLY A 1 74  ? 12.356  9.671   -6.839  1.000 35.616 0 74  GLY A O     1 ? 
ATOM   592  N  N     . GLY A 1 75  ? 11.100  10.460  -5.117  1.000 26.129 0 75  GLY A N     1 ? 
ATOM   593  C  CA    . GLY A 1 75  ? 10.097  9.389   -5.129  1.000 24.013 0 75  GLY A CA    1 ? 
ATOM   594  C  C     . GLY A 1 75  ? 8.956   9.734   -6.051  1.000 20.637 0 75  GLY A C     1 ? 
ATOM   595  O  O     . GLY A 1 75  ? 8.874   10.861  -6.478  1.000 24.986 0 75  GLY A O     1 ? 
ATOM   596  N  N     . GLU A 1 76  ? 8.069   8.774   -6.307  1.000 20.899 0 76  GLU A N     1 ? 
ATOM   597  C  CA    . GLU A 1 76  ? 6.943   8.919   -7.244  1.000 19.242 0 76  GLU A CA    1 ? 
ATOM   598  C  C     . GLU A 1 76  ? 5.625   8.671   -6.513  1.000 17.462 0 76  GLU A C     1 ? 
ATOM   599  O  O     . GLU A 1 76  ? 5.588   7.775   -5.638  1.000 20.723 0 76  GLU A O     1 ? 
ATOM   600  C  CB    . GLU A 1 76  ? 7.031   7.912   -8.394  1.000 23.173 0 76  GLU A CB    1 ? 
ATOM   601  C  CG    . GLU A 1 76  ? 8.274   8.078   -9.271  1.000 27.514 0 76  GLU A CG    1 ? 
ATOM   602  C  CD    . GLU A 1 76  ? 8.313   7.183   -10.507 1.000 31.675 0 76  GLU A CD    1 ? 
ATOM   603  O  OE1   . GLU A 1 76  ? 9.297   7.270   -11.266 1.000 35.638 0 76  GLU A OE1   1 ? 
ATOM   604  O  OE2   . GLU A 1 76  ? 7.372   6.412   -10.708 1.000 31.750 0 76  GLU A OE2   1 ? 
ATOM   605  N  N     . TYR A 1 77  ? 4.595   9.362   -6.946  1.000 17.379 0 77  TYR A N     1 ? 
ATOM   606  C  CA    . TYR A 1 77  ? 3.185   9.077   -6.605  1.000 16.753 0 77  TYR A CA    1 ? 
ATOM   607  C  C     . TYR A 1 77  ? 2.796   7.730   -7.240  1.000 17.838 0 77  TYR A C     1 ? 
ATOM   608  O  O     . TYR A 1 77  ? 3.332   7.363   -8.269  1.000 18.151 0 77  TYR A O     1 ? 
ATOM   609  C  CB    . TYR A 1 77  ? 2.295   10.249  -7.031  1.000 17.895 0 77  TYR A CB    1 ? 
ATOM   610  C  CG    . TYR A 1 77  ? 2.486   11.496  -6.203  1.000 20.725 0 77  TYR A CG    1 ? 
ATOM   611  C  CD1   . TYR A 1 77  ? 3.485   12.433  -6.464  1.000 24.413 0 77  TYR A CD1   1 ? 
ATOM   612  C  CD2   . TYR A 1 77  ? 1.728   11.684  -5.074  1.000 22.361 0 77  TYR A CD2   1 ? 
ATOM   613  C  CE1   . TYR A 1 77  ? 3.661   13.545  -5.636  1.000 24.742 0 77  TYR A CE1   1 ? 
ATOM   614  C  CE2   . TYR A 1 77  ? 1.874   12.785  -4.255  1.000 23.678 0 77  TYR A CE2   1 ? 
ATOM   615  C  CZ    . TYR A 1 77  ? 2.852   13.716  -4.521  1.000 26.368 0 77  TYR A CZ    1 ? 
ATOM   616  O  OH    . TYR A 1 77  ? 2.985   14.773  -3.647  1.000 27.943 0 77  TYR A OH    1 ? 
ATOM   617  N  N     . ASP A 1 78  ? 1.929   6.984   -6.567  1.000 15.208 0 78  ASP A N     1 ? 
ATOM   618  C  CA    . ASP A 1 78  ? 1.497   5.630   -6.979  1.000 14.720 0 78  ASP A CA    1 ? 
ATOM   619  C  C     . ASP A 1 78  ? 0.001   5.685   -7.188  1.000 14.212 0 78  ASP A C     1 ? 
ATOM   620  O  O     . ASP A 1 78  ? -0.718  5.470   -6.239  1.000 14.376 0 78  ASP A O     1 ? 
ATOM   621  C  CB    . ASP A 1 78  ? 1.863   4.581   -5.924  1.000 16.599 0 78  ASP A CB    1 ? 
ATOM   622  C  CG    . ASP A 1 78  ? 1.390   3.200   -6.318  1.000 18.930 0 78  ASP A CG    1 ? 
ATOM   623  O  OD1   . ASP A 1 78  ? 1.487   2.887   -7.510  1.000 18.509 0 78  ASP A OD1   1 ? 
ATOM   624  O  OD2   . ASP A 1 78  ? 0.979   2.426   -5.433  1.000 15.873 0 78  ASP A OD2   1 ? 
ATOM   625  N  N     . ILE A 1 79  ? -0.479  5.987   -8.409  1.000 14.167 0 79  ILE A N     1 ? 
ATOM   626  C  CA    . ILE A 1 79  ? -1.915  6.166   -8.675  1.000 14.217 0 79  ILE A CA    1 ? 
ATOM   627  C  C     . ILE A 1 79  ? -2.498  4.803   -9.069  1.000 15.015 0 79  ILE A C     1 ? 
ATOM   628  O  O     . ILE A 1 79  ? -2.198  4.334   -10.161 1.000 16.256 0 79  ILE A O     1 ? 
ATOM   629  C  CB    . ILE A 1 79  ? -2.125  7.237   -9.770  1.000 18.455 0 79  ILE A CB    1 ? 
ATOM   630  C  CG1   . ILE A 1 79  ? -1.628  8.612   -9.307  1.000 20.077 0 79  ILE A CG1   1 ? 
ATOM   631  C  CG2   . ILE A 1 79  ? -3.578  7.284   -10.208 1.000 18.363 0 79  ILE A CG2   1 ? 
ATOM   632  C  CD1   . ILE A 1 79  ? -1.768  9.717   -10.363 1.000 22.364 0 79  ILE A CD1   1 ? 
ATOM   633  N  N     . ASP A 1 80  ? -3.227  4.145   -8.163  1.000 11.938 0 80  ASP A N     1 ? 
ATOM   634  C  CA    . ASP A 1 80  ? -3.796  2.797   -8.392  1.000 13.457 0 80  ASP A CA    1 ? 
ATOM   635  C  C     . ASP A 1 80  ? -5.232  2.924   -8.874  1.000 12.003 0 80  ASP A C     1 ? 
ATOM   636  O  O     . ASP A 1 80  ? -6.018  3.637   -8.263  1.000 12.420 0 80  ASP A O     1 ? 
ATOM   637  C  CB    . ASP A 1 80  ? -3.719  1.929   -7.157  1.000 13.430 0 80  ASP A CB    1 ? 
ATOM   638  C  CG    . ASP A 1 80  ? -2.313  1.746   -6.608  1.000 15.603 0 80  ASP A CG    1 ? 
ATOM   639  O  OD1   . ASP A 1 80  ? -2.120  2.015   -5.378  1.000 16.692 0 80  ASP A OD1   1 ? 
ATOM   640  O  OD2   . ASP A 1 80  ? -1.388  1.441   -7.398  1.000 14.640 0 80  ASP A OD2   1 ? 
ATOM   641  N  N     . VAL A 1 81  ? -5.564  2.247   -9.988  1.000 13.951 0 81  VAL A N     1 ? 
ATOM   642  C  CA    . VAL A 1 81  ? -6.926  2.290   -10.560 1.000 15.133 0 81  VAL A CA    1 ? 
ATOM   643  C  C     . VAL A 1 81  ? -7.244  0.906   -11.140 1.000 13.556 0 81  VAL A C     1 ? 
ATOM   644  O  O     . VAL A 1 81  ? -6.318  0.201   -11.498 1.000 16.471 0 81  VAL A O     1 ? 
ATOM   645  C  CB    . VAL A 1 81  ? -7.061  3.426   -11.604 1.000 19.279 0 81  VAL A CB    1 ? 
ATOM   646  C  CG1   . VAL A 1 81  ? -6.216  3.167   -12.825 1.000 22.779 0 81  VAL A CG1   1 ? 
ATOM   647  C  CG2   . VAL A 1 81  ? -8.503  3.708   -11.985 1.000 20.762 0 81  VAL A CG2   1 ? 
ATOM   648  N  N     . GLY A 1 82  ? -8.485  0.485   -11.010 1.000 14.083 0 82  GLY A N     1 ? 
ATOM   649  C  CA    . GLY A 1 82  ? -8.972  -0.771  -11.594 1.000 14.509 0 82  GLY A CA    1 ? 
ATOM   650  C  C     . GLY A 1 82  ? -9.796  -0.470  -12.822 1.000 16.481 0 82  GLY A C     1 ? 
ATOM   651  O  O     . GLY A 1 82  ? -10.469 0.545   -12.851 1.000 14.723 0 82  GLY A O     1 ? 
ATOM   652  N  N     . ILE A 1 83  ? -9.651  -1.293  -13.870 1.000 16.528 0 83  ILE A N     1 ? 
ATOM   653  C  CA    . ILE A 1 83  ? -10.539 -1.187  -15.070 1.000 17.889 0 83  ILE A CA    1 ? 
ATOM   654  C  C     . ILE A 1 83  ? -11.157 -2.554  -15.340 1.000 14.651 0 83  ILE A C     1 ? 
ATOM   655  O  O     . ILE A 1 83  ? -10.412 -3.551  -15.391 1.000 15.472 0 83  ILE A O     1 ? 
ATOM   656  C  CB    . ILE A 1 83  ? -9.805  -0.574  -16.270 1.000 18.436 0 83  ILE A CB    1 ? 
ATOM   657  C  CG1   . ILE A 1 83  ? -8.544  -1.341  -16.657 1.000 19.054 0 83  ILE A CG1   1 ? 
ATOM   658  C  CG2   . ILE A 1 83  ? -9.505  0.887   -16.010 1.000 19.030 0 83  ILE A CG2   1 ? 
ATOM   659  C  CD1   . ILE A 1 83  ? -7.957  -0.858  -17.982 1.000 20.628 0 83  ILE A CD1   1 ? 
ATOM   660  N  N     . ILE A 1 84  ? -12.474 -2.600  -15.328 1.000 15.941 0 84  ILE A N     1 ? 
ATOM   661  C  CA    . ILE A 1 84  ? -13.263 -3.842  -15.565 1.000 17.498 0 84  ILE A CA    1 ? 
ATOM   662  C  C     . ILE A 1 84  ? -13.692 -3.820  -17.030 1.000 19.228 0 84  ILE A C     1 ? 
ATOM   663  O  O     . ILE A 1 84  ? -14.539 -2.985  -17.366 1.000 17.757 0 84  ILE A O     1 ? 
ATOM   664  C  CB    . ILE A 1 84  ? -14.482 -3.943  -14.624 1.000 17.672 0 84  ILE A CB    1 ? 
ATOM   665  C  CG1   . ILE A 1 84  ? -14.085 -3.810  -13.145 1.000 17.826 0 84  ILE A CG1   1 ? 
ATOM   666  C  CG2   . ILE A 1 84  ? -15.241 -5.217  -14.884 1.000 17.577 0 84  ILE A CG2   1 ? 
ATOM   667  C  CD1   . ILE A 1 84  ? -15.251 -3.832  -12.207 1.000 19.982 0 84  ILE A CD1   1 ? 
ATOM   668  N  N     . LEU A 1 85  ? -13.039 -4.634  -17.864 1.000 18.472 0 85  LEU A N     1 ? 
ATOM   669  C  CA    . LEU A 1 85  ? -13.295 -4.707  -19.329 1.000 21.472 0 85  LEU A CA    1 ? 
ATOM   670  C  C     . LEU A 1 85  ? -14.575 -5.498  -19.518 1.000 19.826 0 85  LEU A C     1 ? 
ATOM   671  O  O     . LEU A 1 85  ? -14.818 -6.444  -18.758 1.000 19.024 0 85  LEU A O     1 ? 
ATOM   672  C  CB    . LEU A 1 85  ? -12.105 -5.372  -20.027 1.000 22.320 0 85  LEU A CB    1 ? 
ATOM   673  C  CG    . LEU A 1 85  ? -10.908 -4.481  -20.333 1.000 27.250 0 85  LEU A CG    1 ? 
ATOM   674  C  CD1   . LEU A 1 85  ? -11.239 -3.485  -21.406 1.000 26.663 0 85  LEU A CD1   1 ? 
ATOM   675  C  CD2   . LEU A 1 85  ? -10.391 -3.759  -19.087 1.000 29.191 0 85  LEU A CD2   1 ? 
ATOM   676  N  N     . ASN A 1 86  ? -15.396 -5.062  -20.462 1.000 23.125 0 86  ASN A N     1 ? 
ATOM   677  C  CA    . ASN A 1 86  ? -16.695 -5.681  -20.798 1.000 24.633 0 86  ASN A CA    1 ? 
ATOM   678  C  C     . ASN A 1 86  ? -16.430 -6.937  -21.654 1.000 28.561 0 86  ASN A C     1 ? 
ATOM   679  O  O     . ASN A 1 86  ? -16.852 -6.957  -22.820 1.000 27.684 0 86  ASN A O     1 ? 
ATOM   680  C  CB    . ASN A 1 86  ? -17.585 -4.627  -21.455 1.000 27.025 0 86  ASN A CB    1 ? 
ATOM   681  C  CG    . ASN A 1 86  ? -18.926 -5.149  -21.883 1.000 30.588 0 86  ASN A CG    1 ? 
ATOM   682  O  OD1   . ASN A 1 86  ? -19.373 -4.862  -23.000 1.000 34.320 0 86  ASN A OD1   1 ? 
ATOM   683  N  ND2   . ASN A 1 86  ? -19.577 -5.895  -21.009 1.000 26.153 0 86  ASN A ND2   1 ? 
ATOM   684  N  N     . ILE A 1 87  ? -15.716 -7.921  -21.087 1.000 24.409 0 87  ILE A N     1 ? 
ATOM   685  C  CA    . ILE A 1 87  ? -15.208 -9.145  -21.778 1.000 24.168 0 87  ILE A CA    1 ? 
ATOM   686  C  C     . ILE A 1 87  ? -15.468 -10.347 -20.867 1.000 25.945 0 87  ILE A C     1 ? 
ATOM   687  O  O     . ILE A 1 87  ? -15.534 -10.178 -19.623 1.000 24.775 0 87  ILE A O     1 ? 
ATOM   688  C  CB    . ILE A 1 87  ? -13.716 -9.014  -22.162 1.000 22.899 0 87  ILE A CB    1 ? 
ATOM   689  C  CG1   . ILE A 1 87  ? -12.801 -8.981  -20.925 1.000 23.255 0 87  ILE A CG1   1 ? 
ATOM   690  C  CG2   . ILE A 1 87  ? -13.481 -7.809  -23.064 1.000 23.114 0 87  ILE A CG2   1 ? 
ATOM   691  C  CD1   . ILE A 1 87  ? -11.318 -9.023  -21.243 1.000 23.785 0 87  ILE A CD1   1 ? 
ATOM   692  N  N     . ALA A 1 88  ? -15.629 -11.528 -21.448 1.000 24.998 0 88  ALA A N     1 ? 
ATOM   693  C  CA    . ALA A 1 88  ? -15.689 -12.800 -20.717 1.000 24.423 0 88  ALA A CA    1 ? 
ATOM   694  C  C     . ALA A 1 88  ? -14.258 -13.320 -20.555 1.000 27.332 0 88  ALA A C     1 ? 
ATOM   695  O  O     . ALA A 1 88  ? -13.518 -13.338 -21.566 1.000 25.574 0 88  ALA A O     1 ? 
ATOM   696  C  CB    . ALA A 1 88  ? -16.565 -13.792 -21.469 1.000 26.611 0 88  ALA A CB    1 ? 
ATOM   697  N  N     . LYS A 1 89  ? -13.853 -13.644 -19.329 1.000 28.186 0 89  LYS A N     1 ? 
ATOM   698  C  CA    . LYS A 1 89  ? -12.462 -14.076 -19.025 1.000 28.209 0 89  LYS A CA    1 ? 
ATOM   699  C  C     . LYS A 1 89  ? -12.128 -15.332 -19.848 1.000 29.001 0 89  LYS A C     1 ? 
ATOM   700  O  O     . LYS A 1 89  ? -10.990 -15.428 -20.323 1.000 27.513 0 89  LYS A O     1 ? 
ATOM   701  C  CB    . LYS A 1 89  ? -12.255 -14.287 -17.519 1.000 27.485 0 89  LYS A CB    1 ? 
ATOM   702  C  CG    . LYS A 1 89  ? -13.041 -15.417 -16.886 1.000 29.196 0 89  LYS A CG    1 ? 
ATOM   703  C  CD    . LYS A 1 89  ? -12.657 -15.648 -15.435 1.000 28.874 0 89  LYS A CD    1 ? 
ATOM   704  C  CE    . LYS A 1 89  ? -13.458 -16.729 -14.740 1.000 33.607 0 89  LYS A CE    1 ? 
ATOM   705  N  NZ    . LYS A 1 89  ? -13.119 -18.082 -15.238 1.000 39.327 0 89  LYS A NZ    1 ? 
ATOM   706  N  N     . ASP A 1 90  ? -13.113 -16.203 -20.083 1.000 29.514 0 90  ASP A N     1 ? 
ATOM   707  C  CA    . ASP A 1 90  ? -12.911 -17.503 -20.786 1.000 32.123 0 90  ASP A CA    1 ? 
ATOM   708  C  C     . ASP A 1 90  ? -12.593 -17.263 -22.270 1.000 32.391 0 90  ASP A C     1 ? 
ATOM   709  O  O     . ASP A 1 90  ? -12.020 -18.177 -22.875 1.000 38.727 0 90  ASP A O     1 ? 
ATOM   710  C  CB    . ASP A 1 90  ? -14.110 -18.436 -20.585 1.000 33.580 0 90  ASP A CB    1 ? 
ATOM   711  C  CG    . ASP A 1 90  ? -14.209 -19.020 -19.182 1.000 36.182 0 90  ASP A CG    1 ? 
ATOM   712  O  OD1   . ASP A 1 90  ? -13.256 -18.839 -18.405 1.000 37.713 0 90  ASP A OD1   1 ? 
ATOM   713  O  OD2   . ASP A 1 90  ? -15.238 -19.649 -18.882 1.000 41.319 0 90  ASP A OD2   1 ? 
ATOM   714  N  N     . ASP A 1 91  ? -12.865 -16.068 -22.820 1.000 31.550 0 91  ASP A N     1 ? 
ATOM   715  C  CA    . ASP A 1 91  ? -12.652 -15.767 -24.268 1.000 30.802 0 91  ASP A CA    1 ? 
ATOM   716  C  C     . ASP A 1 91  ? -11.209 -15.311 -24.531 1.000 31.061 0 91  ASP A C     1 ? 
ATOM   717  O  O     . ASP A 1 91  ? -10.855 -15.186 -25.697 1.000 32.280 0 91  ASP A O     1 ? 
ATOM   718  C  CB    . ASP A 1 91  ? -13.633 -14.717 -24.798 1.000 29.398 0 91  ASP A CB    1 ? 
ATOM   719  C  CG    . ASP A 1 91  ? -15.049 -15.237 -24.972 1.000 31.239 0 91  ASP A CG    1 ? 
ATOM   720  O  OD1   . ASP A 1 91  ? -15.983 -14.398 -25.107 1.000 31.542 0 91  ASP A OD1   1 ? 
ATOM   721  O  OD2   . ASP A 1 91  ? -15.218 -16.457 -24.911 1.000 34.155 0 91  ASP A OD2   1 ? 
ATOM   722  N  N     . HIS A 1 92  ? -10.417 -14.988 -23.496 1.000 26.911 0 92  HIS A N     1 ? 
ATOM   723  C  CA    . HIS A 1 92  ? -9.185  -14.184 -23.665 1.000 26.618 0 92  HIS A CA    1 ? 
ATOM   724  C  C     . HIS A 1 92  ? -8.086  -14.652 -22.719 1.000 29.625 0 92  HIS A C     1 ? 
ATOM   725  O  O     . HIS A 1 92  ? -8.407  -15.102 -21.589 1.000 29.729 0 92  HIS A O     1 ? 
ATOM   726  C  CB    . HIS A 1 92  ? -9.493  -12.707 -23.442 1.000 27.528 0 92  HIS A CB    1 ? 
ATOM   727  C  CG    . HIS A 1 92  ? -10.600 -12.179 -24.286 1.000 28.057 0 92  HIS A CG    1 ? 
ATOM   728  N  ND1   . HIS A 1 92  ? -10.410 -11.808 -25.602 1.000 29.148 0 92  HIS A ND1   1 ? 
ATOM   729  C  CD2   . HIS A 1 92  ? -11.907 -11.940 -24.004 1.000 27.245 0 92  HIS A CD2   1 ? 
ATOM   730  C  CE1   . HIS A 1 92  ? -11.556 -11.358 -26.095 1.000 27.651 0 92  HIS A CE1   1 ? 
ATOM   731  N  NE2   . HIS A 1 92  ? -12.484 -11.421 -25.129 1.000 30.591 0 92  HIS A NE2   1 ? 
ATOM   732  N  N     . ASP A 1 93  ? -6.844  -14.531 -23.169 1.000 27.283 0 93  ASP A N     1 ? 
ATOM   733  C  CA    . ASP A 1 93  ? -5.616  -14.743 -22.364 1.000 28.692 0 93  ASP A CA    1 ? 
ATOM   734  C  C     . ASP A 1 93  ? -5.403  -13.488 -21.508 1.000 27.037 0 93  ASP A C     1 ? 
ATOM   735  O  O     . ASP A 1 93  ? -5.488  -12.376 -22.023 1.000 23.764 0 93  ASP A O     1 ? 
ATOM   736  C  CB    . ASP A 1 93  ? -4.427  -15.043 -23.282 1.000 28.654 0 93  ASP A CB    1 ? 
ATOM   737  C  CG    . ASP A 1 93  ? -3.095  -15.182 -22.570 1.000 30.610 0 93  ASP A CG    1 ? 
ATOM   738  O  OD1   . ASP A 1 93  ? -2.777  -16.301 -22.149 1.000 37.190 0 93  ASP A OD1   1 ? 
ATOM   739  O  OD2   . ASP A 1 93  ? -2.386  -14.164 -22.454 1.000 31.157 0 93  ASP A OD2   1 ? 
ATOM   740  N  N     . PRO A 1 94  ? -5.124  -13.621 -20.187 1.000 24.596 0 94  PRO A N     1 ? 
ATOM   741  C  CA    . PRO A 1 94  ? -4.971  -12.445 -19.320 1.000 24.507 0 94  PRO A CA    1 ? 
ATOM   742  C  C     . PRO A 1 94  ? -3.811  -11.537 -19.760 1.000 22.800 0 94  PRO A C     1 ? 
ATOM   743  O  O     . PRO A 1 94  ? -3.961  -10.335 -19.735 1.000 21.388 0 94  PRO A O     1 ? 
ATOM   744  C  CB    . PRO A 1 94  ? -4.736  -13.046 -17.927 1.000 24.681 0 94  PRO A CB    1 ? 
ATOM   745  C  CG    . PRO A 1 94  ? -4.157  -14.427 -18.207 1.000 25.570 0 94  PRO A CG    1 ? 
ATOM   746  C  CD    . PRO A 1 94  ? -4.843  -14.874 -19.485 1.000 24.619 0 94  PRO A CD    1 ? 
ATOM   747  N  N     . VAL A 1 95  ? -2.692  -12.108 -20.240 1.000 24.161 0 95  VAL A N     1 ? 
ATOM   748  C  CA    . VAL A 1 95  ? -1.554  -11.282 -20.757 1.000 25.352 0 95  VAL A CA    1 ? 
ATOM   749  C  C     . VAL A 1 95  ? -1.939  -10.658 -22.116 1.000 22.855 0 95  VAL A C     1 ? 
ATOM   750  O  O     . VAL A 1 95  ? -1.533  -9.514  -22.343 1.000 24.811 0 95  VAL A O     1 ? 
ATOM   751  C  CB    . VAL A 1 95  ? -0.240  -12.081 -20.826 1.000 27.229 0 95  VAL A CB    1 ? 
ATOM   752  C  CG1   . VAL A 1 95  ? 0.929   -11.226 -21.308 1.000 24.998 0 95  VAL A CG1   1 ? 
ATOM   753  C  CG2   . VAL A 1 95  ? 0.077   -12.712 -19.489 1.000 30.128 0 95  VAL A CG2   1 ? 
ATOM   754  N  N     . GLU A 1 96  ? -2.669  -11.402 -22.984 1.000 26.296 0 96  GLU A N     1 ? 
ATOM   755  C  CA    . GLU A 1 96  ? -3.347  -10.867 -24.208 1.000 30.185 0 96  GLU A CA    1 ? 
ATOM   756  C  C     . GLU A 1 96  ? -4.057  -9.557  -23.859 1.000 26.292 0 96  GLU A C     1 ? 
ATOM   757  O  O     . GLU A 1 96  ? -3.901  -8.582  -24.582 1.000 28.098 0 96  GLU A O     1 ? 
ATOM   758  C  CB    . GLU A 1 96  ? -4.369  -11.873 -24.776 1.000 34.809 0 96  GLU A CB    1 ? 
ATOM   759  C  CG    . GLU A 1 96  ? -5.316  -11.289 -25.840 1.000 40.469 0 96  GLU A CG    1 ? 
ATOM   760  C  CD    . GLU A 1 96  ? -6.347  -12.264 -26.422 1.000 44.235 0 96  GLU A CD    1 ? 
ATOM   761  O  OE1   . GLU A 1 96  ? -6.312  -13.470 -26.045 1.000 50.610 0 96  GLU A OE1   1 ? 
ATOM   762  O  OE2   . GLU A 1 96  ? -7.198  -11.819 -27.265 1.000 45.349 0 96  GLU A OE2   1 ? 
ATOM   763  N  N     . VAL A 1 97  ? -4.867  -9.574  -22.816 1.000 25.254 0 97  VAL A N     1 ? 
ATOM   764  C  CA    . VAL A 1 97  ? -5.759  -8.438  -22.480 1.000 24.238 0 97  VAL A CA    1 ? 
ATOM   765  C  C     . VAL A 1 97  ? -4.916  -7.286  -21.938 1.000 24.053 0 97  VAL A C     1 ? 
ATOM   766  O  O     . VAL A 1 97  ? -5.182  -6.138  -22.323 1.000 26.037 0 97  VAL A O     1 ? 
ATOM   767  C  CB    . VAL A 1 97  ? -6.869  -8.856  -21.514 1.000 22.753 0 97  VAL A CB    1 ? 
ATOM   768  C  CG1   . VAL A 1 97  ? -7.713  -7.663  -21.082 1.000 23.419 0 97  VAL A CG1   1 ? 
ATOM   769  C  CG2   . VAL A 1 97  ? -7.745  -9.932  -22.135 1.000 26.018 0 97  VAL A CG2   1 ? 
ATOM   770  N  N     . LYS A 1 98  ? -3.871  -7.575  -21.164 1.000 24.947 0 98  LYS A N     1 ? 
ATOM   771  C  CA    . LYS A 1 98  ? -2.970  -6.513  -20.661 1.000 24.874 0 98  LYS A CA    1 ? 
ATOM   772  C  C     . LYS A 1 98  ? -2.183  -5.914  -21.829 1.000 24.116 0 98  LYS A C     1 ? 
ATOM   773  O  O     . LYS A 1 98  ? -1.913  -4.748  -21.784 1.000 23.572 0 98  LYS A O     1 ? 
ATOM   774  C  CB    . LYS A 1 98  ? -2.081  -7.044  -19.537 1.000 23.761 0 98  LYS A CB    1 ? 
ATOM   775  C  CG    . LYS A 1 98  ? -2.812  -7.256  -18.217 1.000 22.437 0 98  LYS A CG    1 ? 
ATOM   776  C  CD    . LYS A 1 98  ? -1.876  -7.481  -17.035 1.000 21.070 0 98  LYS A CD    1 ? 
ATOM   777  C  CE    . LYS A 1 98  ? -1.298  -8.873  -17.007 1.000 21.078 0 98  LYS A CE    1 ? 
ATOM   778  N  NZ    . LYS A 1 98  ? -0.574  -9.164  -15.752 1.000 21.841 0 98  LYS A NZ    1 ? 
ATOM   779  N  N     . LYS A 1 99  ? -1.892  -6.696  -22.890 1.000 26.927 0 99  LYS A N     1 ? 
ATOM   780  C  CA    . LYS A 1 99  ? -1.214  -6.169  -24.105 1.000 29.079 0 99  LYS A CA    1 ? 
ATOM   781  C  C     . LYS A 1 99  ? -2.125  -5.144  -24.805 1.000 25.614 0 99  LYS A C     1 ? 
ATOM   782  O  O     . LYS A 1 99  ? -1.591  -4.100  -25.224 1.000 27.752 0 99  LYS A O     1 ? 
ATOM   783  C  CB    . LYS A 1 99  ? -0.786  -7.292  -25.059 1.000 32.350 0 99  LYS A CB    1 ? 
ATOM   784  C  CG    . LYS A 1 99  ? 0.686   -7.696  -24.957 1.000 38.316 0 99  LYS A CG    1 ? 
ATOM   785  C  CD    . LYS A 1 99  ? 1.032   -8.988  -25.714 1.000 40.585 0 99  LYS A CD    1 ? 
ATOM   786  C  CE    . LYS A 1 99  ? 2.368   -9.578  -25.304 1.000 43.942 0 99  LYS A CE    1 ? 
ATOM   787  N  NZ    . LYS A 1 99  ? 2.686   -10.826 -26.049 1.000 45.652 0 99  LYS A NZ    1 ? 
ATOM   788  N  N     . TRP A 1 100 ? -3.447  -5.377  -24.864 1.000 23.952 0 100 TRP A N     1 ? 
ATOM   789  C  CA    . TRP A 1 100 ? -4.395  -4.360  -25.397 1.000 22.521 0 100 TRP A CA    1 ? 
ATOM   790  C  C     . TRP A 1 100 ? -4.107  -3.041  -24.680 1.000 25.040 0 100 TRP A C     1 ? 
ATOM   791  O  O     . TRP A 1 100 ? -3.974  -1.999  -25.338 1.000 28.326 0 100 TRP A O     1 ? 
ATOM   792  C  CB    . TRP A 1 100 ? -5.864  -4.739  -25.198 1.000 25.601 0 100 TRP A CB    1 ? 
ATOM   793  C  CG    . TRP A 1 100 ? -6.316  -6.037  -25.773 1.000 26.129 0 100 TRP A CG    1 ? 
ATOM   794  C  CD1   . TRP A 1 100 ? -5.731  -6.779  -26.760 1.000 27.999 0 100 TRP A CD1   1 ? 
ATOM   795  C  CD2   . TRP A 1 100 ? -7.554  -6.687  -25.459 1.000 26.731 0 100 TRP A CD2   1 ? 
ATOM   796  N  NE1   . TRP A 1 100 ? -6.485  -7.892  -27.018 1.000 30.100 0 100 TRP A NE1   1 ? 
ATOM   797  C  CE2   . TRP A 1 100 ? -7.618  -7.856  -26.248 1.000 29.185 0 100 TRP A CE2   1 ? 
ATOM   798  C  CE3   . TRP A 1 100 ? -8.602  -6.412  -24.577 1.000 25.616 0 100 TRP A CE3   1 ? 
ATOM   799  C  CZ2   . TRP A 1 100 ? -8.695  -8.735  -26.176 1.000 26.788 0 100 TRP A CZ2   1 ? 
ATOM   800  C  CZ3   . TRP A 1 100 ? -9.661  -7.288  -24.499 1.000 27.268 0 100 TRP A CZ3   1 ? 
ATOM   801  C  CH2   . TRP A 1 100 ? -9.694  -8.445  -25.279 1.000 28.518 0 100 TRP A CH2   1 ? 
ATOM   802  N  N     . ILE A 1 101 ? -4.008  -3.094  -23.351 1.000 23.865 0 101 ILE A N     1 ? 
ATOM   803  C  CA    . ILE A 1 101 ? -3.952  -1.877  -22.508 1.000 24.991 0 101 ILE A CA    1 ? 
ATOM   804  C  C     . ILE A 1 101 ? -2.563  -1.252  -22.665 1.000 24.776 0 101 ILE A C     1 ? 
ATOM   805  O  O     . ILE A 1 101 ? -2.491  -0.044  -22.845 1.000 24.696 0 101 ILE A O     1 ? 
ATOM   806  C  CB    . ILE A 1 101 ? -4.306  -2.216  -21.045 1.000 23.766 0 101 ILE A CB    1 ? 
ATOM   807  C  CG1   . ILE A 1 101 ? -5.693  -2.850  -20.919 1.000 23.241 0 101 ILE A CG1   1 ? 
ATOM   808  C  CG2   . ILE A 1 101 ? -4.166  -0.984  -20.158 1.000 25.318 0 101 ILE A CG2   1 ? 
ATOM   809  C  CD1   . ILE A 1 101 ? -6.839  -1.982  -21.388 1.000 19.893 0 101 ILE A CD1   1 ? 
ATOM   810  N  N     . ARG A 1 102 ? -1.514  -2.078  -22.662 1.000 27.254 0 102 ARG A N     1 ? 
ATOM   811  C  CA    . ARG A 1 102 ? -0.098  -1.646  -22.856 1.000 29.668 0 102 ARG A CA    1 ? 
ATOM   812  C  C     . ARG A 1 102 ? 0.039   -0.941  -24.211 1.000 31.156 0 102 ARG A C     1 ? 
ATOM   813  O  O     . ARG A 1 102 ? 0.646   0.151   -24.248 1.000 31.130 0 102 ARG A O     1 ? 
ATOM   814  C  CB    . ARG A 1 102 ? 0.849   -2.854  -22.773 1.000 33.003 0 102 ARG A CB    1 ? 
ATOM   815  C  CG    . ARG A 1 102 ? 2.332   -2.492  -22.663 1.000 35.870 0 102 ARG A CG    1 ? 
ATOM   816  C  CD    . ARG A 1 102 ? 3.083   -2.359  -23.999 1.000 37.651 0 102 ARG A CD    1 ? 
ATOM   817  N  NE    . ARG A 1 102 ? 2.855   -3.466  -24.924 1.000 37.260 0 102 ARG A NE    1 ? 
ATOM   818  C  CZ    . ARG A 1 102 ? 3.492   -4.639  -24.895 1.000 39.677 0 102 ARG A CZ    1 ? 
ATOM   819  N  NH1   . ARG A 1 102 ? 4.423   -4.872  -23.990 1.000 45.300 0 102 ARG A NH1   1 ? 
ATOM   820  N  NH2   . ARG A 1 102 ? 3.186   -5.580  -25.769 1.000 38.926 0 102 ARG A NH2   1 ? 
ATOM   821  N  N     . ASP A 1 103 ? -0.505  -1.554  -25.267 1.000 32.494 0 103 ASP A N     1 ? 
ATOM   822  C  CA    . ASP A 1 103 ? -0.448  -1.048  -26.668 1.000 31.505 0 103 ASP A CA    1 ? 
ATOM   823  C  C     . ASP A 1 103 ? -1.263  0.245   -26.758 1.000 31.381 0 103 ASP A C     1 ? 
ATOM   824  O  O     . ASP A 1 103 ? -0.753  1.212   -27.325 1.000 32.821 0 103 ASP A O     1 ? 
ATOM   825  C  CB    . ASP A 1 103 ? -0.943  -2.094  -27.682 1.000 30.729 0 103 ASP A CB    1 ? 
ATOM   826  C  CG    . ASP A 1 103 ? -0.046  -3.321  -27.832 1.000 28.515 0 103 ASP A CG    1 ? 
ATOM   827  O  OD1   . ASP A 1 103 ? -0.536  -4.322  -28.404 1.000 30.070 0 103 ASP A OD1   1 ? 
ATOM   828  O  OD2   . ASP A 1 103 ? 1.084   -3.306  -27.274 1.000 28.252 0 103 ASP A OD2   1 ? 
ATOM   829  N  N     . ALA A 1 104 ? -2.458  0.281   -26.157 1.000 32.810 0 104 ALA A N     1 ? 
ATOM   830  C  CA    . ALA A 1 104 ? -3.297  1.503   -26.069 1.000 32.447 0 104 ALA A CA    1 ? 
ATOM   831  C  C     . ALA A 1 104 ? -2.466  2.676   -25.517 1.000 33.085 0 104 ALA A C     1 ? 
ATOM   832  O  O     . ALA A 1 104 ? -2.677  3.805   -25.976 1.000 33.111 0 104 ALA A O     1 ? 
ATOM   833  C  CB    . ALA A 1 104 ? -4.523  1.246   -25.229 1.000 33.108 0 104 ALA A CB    1 ? 
ATOM   834  N  N     . LEU A 1 105 ? -1.549  2.419   -24.573 1.000 35.705 0 105 LEU A N     1 ? 
ATOM   835  C  CA    . LEU A 1 105 ? -0.809  3.481   -23.825 1.000 38.691 0 105 LEU A CA    1 ? 
ATOM   836  C  C     . LEU A 1 105 ? 0.637   3.591   -24.324 1.000 43.708 0 105 LEU A C     1 ? 
ATOM   837  O  O     . LEU A 1 105 ? 1.447   4.238   -23.626 1.000 41.499 0 105 LEU A O     1 ? 
ATOM   838  C  CB    . LEU A 1 105 ? -0.820  3.149   -22.329 1.000 37.160 0 105 LEU A CB    1 ? 
ATOM   839  C  CG    . LEU A 1 105 ? -2.145  3.364   -21.609 1.000 35.780 0 105 LEU A CG    1 ? 
ATOM   840  C  CD1   . LEU A 1 105 ? -2.106  2.720   -20.241 1.000 32.595 0 105 LEU A CD1   1 ? 
ATOM   841  C  CD2   . LEU A 1 105 ? -2.468  4.843   -21.485 1.000 33.853 0 105 LEU A CD2   1 ? 
ATOM   842  N  N     . LYS A 1 106 ? 0.950   2.987   -25.471 1.000 50.817 0 106 LYS A N     1 ? 
ATOM   843  C  CA    . LYS A 1 106 ? 2.334   2.899   -26.015 1.000 57.211 0 106 LYS A CA    1 ? 
ATOM   844  C  C     . LYS A 1 106 ? 2.977   4.300   -26.047 1.000 55.029 0 106 LYS A C     1 ? 
ATOM   845  O  O     . LYS A 1 106 ? 4.151   4.414   -25.625 1.000 52.026 0 106 LYS A O     1 ? 
ATOM   846  C  CB    . LYS A 1 106 ? 2.324   2.267   -27.410 1.000 65.150 0 106 LYS A CB    1 ? 
ATOM   847  C  CG    . LYS A 1 106 ? 3.705   2.015   -28.003 1.000 77.683 0 106 LYS A CG    1 ? 
ATOM   848  C  CD    . LYS A 1 106 ? 3.689   1.607   -29.463 1.000 84.030 0 106 LYS A CD    1 ? 
ATOM   849  C  CE    . LYS A 1 106 ? 5.085   1.450   -30.038 1.000 86.420 0 106 LYS A CE    1 ? 
ATOM   850  N  NZ    . LYS A 1 106 ? 5.054   1.127   -31.485 1.000 89.097 0 106 LYS A NZ    1 ? 
ATOM   851  N  N     . ASP A 1 107 ? 2.232   5.321   -26.505 1.000 52.081 0 107 ASP A N     1 ? 
ATOM   852  C  CA    . ASP A 1 107 ? 2.753   6.687   -26.798 1.000 51.757 0 107 ASP A CA    1 ? 
ATOM   853  C  C     . ASP A 1 107 ? 2.473   7.655   -25.632 1.000 48.683 0 107 ASP A C     1 ? 
ATOM   854  O  O     . ASP A 1 107 ? 2.730   8.863   -25.815 1.000 46.023 0 107 ASP A O     1 ? 
ATOM   855  C  CB    . ASP A 1 107 ? 2.125   7.272   -28.070 1.000 56.437 0 107 ASP A CB    1 ? 
ATOM   856  C  CG    . ASP A 1 107 ? 2.211   6.383   -29.302 1.000 60.229 0 107 ASP A CG    1 ? 
ATOM   857  O  OD1   . ASP A 1 107 ? 3.301   5.827   -29.559 1.000 56.288 0 107 ASP A OD1   1 ? 
ATOM   858  O  OD2   . ASP A 1 107 ? 1.192   6.282   -30.013 1.000 63.852 0 107 ASP A OD2   1 ? 
ATOM   859  N  N     . TYR A 1 108 ? 1.922   7.179   -24.505 1.000 45.294 0 108 TYR A N     1 ? 
ATOM   860  C  CA    . TYR A 1 108 ? 1.536   8.036   -23.347 1.000 42.503 0 108 TYR A CA    1 ? 
ATOM   861  C  C     . TYR A 1 108 ? 2.710   8.105   -22.369 1.000 40.507 0 108 TYR A C     1 ? 
ATOM   862  O  O     . TYR A 1 108 ? 3.233   7.051   -22.008 1.000 41.438 0 108 TYR A O     1 ? 
ATOM   863  C  CB    . TYR A 1 108 ? 0.273   7.512   -22.652 1.000 42.492 0 108 TYR A CB    1 ? 
ATOM   864  C  CG    . TYR A 1 108 ? -0.297  8.451   -21.613 1.000 38.417 0 108 TYR A CG    1 ? 
ATOM   865  C  CD1   . TYR A 1 108 ? -1.245  9.398   -21.956 1.000 38.146 0 108 TYR A CD1   1 ? 
ATOM   866  C  CD2   . TYR A 1 108 ? 0.150   8.433   -20.295 1.000 37.550 0 108 TYR A CD2   1 ? 
ATOM   867  C  CE1   . TYR A 1 108 ? -1.754  10.288  -21.021 1.000 37.010 0 108 TYR A CE1   1 ? 
ATOM   868  C  CE2   . TYR A 1 108 ? -0.338  9.331   -19.352 1.000 35.677 0 108 TYR A CE2   1 ? 
ATOM   869  C  CZ    . TYR A 1 108 ? -1.291  10.264  -19.717 1.000 33.801 0 108 TYR A CZ    1 ? 
ATOM   870  O  OH    . TYR A 1 108 ? -1.802  11.148  -18.805 1.000 34.055 0 108 TYR A OH    1 ? 
ATOM   871  N  N     . GLY A 1 109 ? 3.105   9.320   -21.975 1.000 45.003 0 109 GLY A N     1 ? 
ATOM   872  C  CA    . GLY A 1 109 ? 4.196   9.568   -21.011 1.000 46.119 0 109 GLY A CA    1 ? 
ATOM   873  C  C     . GLY A 1 109 ? 5.483   8.898   -21.439 1.000 46.294 0 109 GLY A C     1 ? 
ATOM   874  O  O     . GLY A 1 109 ? 5.757   8.877   -22.647 1.000 50.055 0 109 GLY A O     1 ? 
ATOM   875  N  N     . ASN A 1 110 ? 6.222   8.330   -20.483 1.000 44.007 0 110 ASN A N     1 ? 
ATOM   876  C  CA    . ASN A 1 110 ? 7.474   7.565   -20.721 1.000 44.352 0 110 ASN A CA    1 ? 
ATOM   877  C  C     . ASN A 1 110 ? 7.126   6.108   -21.040 1.000 42.212 0 110 ASN A C     1 ? 
ATOM   878  O  O     . ASN A 1 110 ? 7.994   5.253   -20.857 1.000 45.604 0 110 ASN A O     1 ? 
ATOM   879  C  CB    . ASN A 1 110 ? 8.426   7.634   -19.521 1.000 45.954 0 110 ASN A CB    1 ? 
ATOM   880  C  CG    . ASN A 1 110 ? 8.544   9.026   -18.934 1.000 50.474 0 110 ASN A CG    1 ? 
ATOM   881  O  OD1   . ASN A 1 110 ? 8.596   9.194   -17.715 1.000 55.583 0 110 ASN A OD1   1 ? 
ATOM   882  N  ND2   . ASN A 1 110 ? 8.585   10.031  -19.791 1.000 53.896 0 110 ASN A ND2   1 ? 
ATOM   883  N  N     . GLY A 1 111 ? 5.895   5.847   -21.488 1.000 41.642 0 111 GLY A N     1 ? 
ATOM   884  C  CA    . GLY A 1 111 ? 5.447   4.523   -21.952 1.000 43.071 0 111 GLY A CA    1 ? 
ATOM   885  C  C     . GLY A 1 111 ? 4.964   3.649   -20.803 1.000 42.736 0 111 GLY A C     1 ? 
ATOM   886  O  O     . GLY A 1 111 ? 4.828   4.174   -19.649 1.000 39.743 0 111 GLY A O     1 ? 
ATOM   887  N  N     . ALA A 1 112 ? 4.721   2.370   -21.099 1.000 39.133 0 112 ALA A N     1 ? 
ATOM   888  C  CA    . ALA A 1 112 ? 3.892   1.442   -20.301 1.000 34.883 0 112 ALA A CA    1 ? 
ATOM   889  C  C     . ALA A 1 112 ? 4.531   0.056   -20.307 1.000 36.691 0 112 ALA A C     1 ? 
ATOM   890  O  O     . ALA A 1 112 ? 5.210   -0.294  -21.293 1.000 38.727 0 112 ALA A O     1 ? 
ATOM   891  C  CB    . ALA A 1 112 ? 2.481   1.404   -20.838 1.000 35.308 0 112 ALA A CB    1 ? 
ATOM   892  N  N     . GLU A 1 113 ? 4.316   -0.696  -19.242 1.000 33.087 0 113 GLU A N     1 ? 
ATOM   893  C  CA    . GLU A 1 113 ? 4.983   -1.988  -18.958 1.000 33.899 0 113 GLU A CA    1 ? 
ATOM   894  C  C     . GLU A 1 113 ? 3.930   -2.950  -18.407 1.000 34.176 0 113 GLU A C     1 ? 
ATOM   895  O  O     . GLU A 1 113 ? 3.087   -2.500  -17.618 1.000 29.465 0 113 GLU A O     1 ? 
ATOM   896  C  CB    . GLU A 1 113 ? 6.138   -1.705  -17.996 1.000 39.151 0 113 GLU A CB    1 ? 
ATOM   897  C  CG    . GLU A 1 113 ? 6.811   -2.920  -17.407 1.000 46.883 0 113 GLU A CG    1 ? 
ATOM   898  C  CD    . GLU A 1 113 ? 7.816   -2.541  -16.327 1.000 52.604 0 113 GLU A CD    1 ? 
ATOM   899  O  OE1   . GLU A 1 113 ? 8.404   -1.440  -16.445 1.000 57.094 0 113 GLU A OE1   1 ? 
ATOM   900  O  OE2   . GLU A 1 113 ? 7.965   -3.310  -15.339 1.000 54.668 0 113 GLU A OE2   1 ? 
ATOM   901  N  N     . ILE A 1 114 ? 3.912   -4.192  -18.876 1.000 29.609 0 114 ILE A N     1 ? 
ATOM   902  C  CA    . ILE A 1 114 ? 3.064   -5.263  -18.296 1.000 28.669 0 114 ILE A CA    1 ? 
ATOM   903  C  C     . ILE A 1 114 ? 3.787   -5.824  -17.068 1.000 30.098 0 114 ILE A C     1 ? 
ATOM   904  O  O     . ILE A 1 114 ? 4.958   -6.255  -17.187 1.000 29.321 0 114 ILE A O     1 ? 
ATOM   905  C  CB    . ILE A 1 114 ? 2.698   -6.337  -19.330 1.000 26.927 0 114 ILE A CB    1 ? 
ATOM   906  C  CG1   . ILE A 1 114 ? 1.915   -5.731  -20.496 1.000 28.411 0 114 ILE A CG1   1 ? 
ATOM   907  C  CG2   . ILE A 1 114 ? 1.927   -7.478  -18.672 1.000 28.426 0 114 ILE A CG2   1 ? 
ATOM   908  C  CD1   . ILE A 1 114 ? 1.797   -6.641  -21.704 1.000 29.728 0 114 ILE A CD1   1 ? 
ATOM   909  N  N     . ARG A 1 115 ? 3.153   -5.708  -15.912 1.000 30.413 0 115 ARG A N     1 ? 
ATOM   910  C  CA    . ARG A 1 115 ? 3.651   -6.289  -14.653 1.000 28.709 0 115 ARG A CA    1 ? 
ATOM   911  C  C     . ARG A 1 115 ? 2.782   -7.496  -14.313 1.000 26.353 0 115 ARG A C     1 ? 
ATOM   912  O  O     . ARG A 1 115 ? 1.769   -7.717  -14.994 1.000 24.543 0 115 ARG A O     1 ? 
ATOM   913  C  CB    . ARG A 1 115 ? 3.665   -5.211  -13.562 1.000 31.723 0 115 ARG A CB    1 ? 
ATOM   914  C  CG    . ARG A 1 115 ? 4.356   -3.910  -13.965 1.000 36.241 0 115 ARG A CG    1 ? 
ATOM   915  C  CD    . ARG A 1 115 ? 5.609   -3.687  -13.151 1.000 41.866 0 115 ARG A CD    1 ? 
ATOM   916  N  NE    . ARG A 1 115 ? 6.245   -2.376  -13.295 1.000 44.524 0 115 ARG A NE    1 ? 
ATOM   917  C  CZ    . ARG A 1 115 ? 6.089   -1.351  -12.452 1.000 49.076 0 115 ARG A CZ    1 ? 
ATOM   918  N  NH1   . ARG A 1 115 ? 5.233   -1.430  -11.445 1.000 54.695 0 115 ARG A NH1   1 ? 
ATOM   919  N  NH2   . ARG A 1 115 ? 6.775   -0.237  -12.636 1.000 50.991 0 115 ARG A NH2   1 ? 
ATOM   920  N  N     . ARG A 1 116 ? 3.214   -8.314  -13.369 1.000 24.149 0 116 ARG A N     1 ? 
ATOM   921  C  CA    . ARG A 1 116 ? 2.518   -9.565  -13.024 1.000 25.387 0 116 ARG A CA    1 ? 
ATOM   922  C  C     . ARG A 1 116 ? 1.027   -9.238  -12.801 1.000 20.909 0 116 ARG A C     1 ? 
ATOM   923  O  O     . ARG A 1 116 ? 0.195   -10.016 -13.241 1.000 20.696 0 116 ARG A O     1 ? 
ATOM   924  C  CB    . ARG A 1 116 ? 3.168   -10.216 -11.801 1.000 32.195 0 116 ARG A CB    1 ? 
ATOM   925  C  CG    . ARG A 1 116 ? 2.969   -11.723 -11.711 1.000 42.836 0 116 ARG A CG    1 ? 
ATOM   926  C  CD    . ARG A 1 116 ? 4.051   -12.402 -10.876 1.000 49.558 0 116 ARG A CD    1 ? 
ATOM   927  N  NE    . ARG A 1 116 ? 4.346   -13.751 -11.364 1.000 62.307 0 116 ARG A NE    1 ? 
ATOM   928  C  CZ    . ARG A 1 116 ? 5.138   -14.034 -12.406 1.000 62.473 0 116 ARG A CZ    1 ? 
ATOM   929  N  NH1   . ARG A 1 116 ? 5.745   -13.066 -13.068 1.000 68.294 0 116 ARG A NH1   1 ? 
ATOM   930  N  NH2   . ARG A 1 116 ? 5.326   -15.290 -12.773 1.000 66.035 0 116 ARG A NH2   1 ? 
ATOM   931  N  N     . SER A 1 117 ? 0.712   -8.121  -12.135 1.000 21.584 0 117 SER A N     1 ? 
ATOM   932  C  CA    . SER A 1 117 ? -0.655  -7.862  -11.611 1.000 23.348 0 117 SER A CA    1 ? 
ATOM   933  C  C     . SER A 1 117 ? -1.236  -6.536  -12.117 1.000 20.164 0 117 SER A C     1 ? 
ATOM   934  O  O     . SER A 1 117 ? -2.343  -6.220  -11.740 1.000 20.447 0 117 SER A O     1 ? 
ATOM   935  C  CB    . SER A 1 117 ? -0.662  -7.919  -10.127 1.000 24.030 0 117 SER A CB    1 ? 
ATOM   936  O  OG    . SER A 1 117 ? -0.260  -9.213  -9.691  1.000 29.589 0 117 SER A OG    1 ? 
ATOM   937  N  N     . CYS A 1 118 ? -0.587  -5.843  -13.031 1.000 19.442 0 118 CYS A N     1 ? 
ATOM   938  C  CA    . CYS A 1 118 ? -1.112  -4.573  -13.568 1.000 18.343 0 118 CYS A CA    1 ? 
ATOM   939  C  C     . CYS A 1 118 ? -0.369  -4.207  -14.838 1.000 22.067 0 118 CYS A C     1 ? 
ATOM   940  O  O     . CYS A 1 118 ? 0.688   -4.823  -15.126 1.000 22.086 0 118 CYS A O     1 ? 
ATOM   941  C  CB    . CYS A 1 118 ? -1.006  -3.435  -12.546 1.000 17.968 0 118 CYS A CB    1 ? 
ATOM   942  S  SG    . CYS A 1 118 ? 0.690   -3.065  -12.032 1.000 22.710 0 118 CYS A SG    1 ? 
ATOM   943  N  N     . VAL A 1 119 ? -0.861  -3.200  -15.513 1.000 21.137 0 119 VAL A N     1 ? 
ATOM   944  C  CA    . VAL A 1 119 ? -0.101  -2.460  -16.528 1.000 21.612 0 119 VAL A CA    1 ? 
ATOM   945  C  C     . VAL A 1 119 ? 0.270   -1.124  -15.919 1.000 23.109 0 119 VAL A C     1 ? 
ATOM   946  O  O     . VAL A 1 119 ? -0.613  -0.462  -15.400 1.000 22.647 0 119 VAL A O     1 ? 
ATOM   947  C  CB    . VAL A 1 119 ? -0.918  -2.316  -17.819 1.000 22.206 0 119 VAL A CB    1 ? 
ATOM   948  C  CG1   . VAL A 1 119 ? -0.208  -1.433  -18.820 1.000 22.805 0 119 VAL A CG1   1 ? 
ATOM   949  C  CG2   . VAL A 1 119 ? -1.238  -3.681  -18.417 1.000 22.934 0 119 VAL A CG2   1 ? 
ATOM   950  N  N     . THR A 1 120 ? 1.550   -0.781  -15.915 1.000 23.891 0 120 THR A N     1 ? 
ATOM   951  C  CA    . THR A 1 120 ? 2.047   0.449   -15.276 1.000 22.003 0 120 THR A CA    1 ? 
ATOM   952  C  C     . THR A 1 120 ? 2.446   1.423   -16.372 1.000 24.995 0 120 THR A C     1 ? 
ATOM   953  O  O     . THR A 1 120 ? 3.212   1.002   -17.262 1.000 26.492 0 120 THR A O     1 ? 
ATOM   954  C  CB    . THR A 1 120 ? 3.219   0.148   -14.341 1.000 24.562 0 120 THR A CB    1 ? 
ATOM   955  O  OG1   . THR A 1 120 ? 2.751   -0.745  -13.315 1.000 24.969 0 120 THR A OG1   1 ? 
ATOM   956  C  CG2   . THR A 1 120 ? 3.809   1.404   -13.757 1.000 23.406 0 120 THR A CG2   1 ? 
ATOM   957  N  N     . VAL A 1 121 ? 1.951   2.651   -16.315 1.000 25.678 0 121 VAL A N     1 ? 
ATOM   958  C  CA    . VAL A 1 121 ? 2.367   3.755   -17.222 1.000 29.708 0 121 VAL A CA    1 ? 
ATOM   959  C  C     . VAL A 1 121 ? 3.129   4.798   -16.401 1.000 31.620 0 121 VAL A C     1 ? 
ATOM   960  O  O     . VAL A 1 121 ? 2.745   5.057   -15.232 1.000 28.571 0 121 VAL A O     1 ? 
ATOM   961  C  CB    . VAL A 1 121 ? 1.163   4.346   -17.980 1.000 32.821 0 121 VAL A CB    1 ? 
ATOM   962  C  CG1   . VAL A 1 121 ? 0.083   4.828   -17.052 1.000 32.606 0 121 VAL A CG1   1 ? 
ATOM   963  C  CG2   . VAL A 1 121 ? 1.574   5.447   -18.940 1.000 34.564 0 121 VAL A CG2   1 ? 
ATOM   964  N  N     . PHE A 1 122 ? 4.203   5.351   -16.966 1.000 31.884 0 122 PHE A N     1 ? 
ATOM   965  C  CA    . PHE A 1 122 ? 5.109   6.282   -16.259 1.000 32.708 0 122 PHE A CA    1 ? 
ATOM   966  C  C     . PHE A 1 122 ? 4.901   7.710   -16.765 1.000 34.067 0 122 PHE A C     1 ? 
ATOM   967  O  O     . PHE A 1 122 ? 4.748   7.928   -17.974 1.000 31.029 0 122 PHE A O     1 ? 
ATOM   968  C  CB    . PHE A 1 122 ? 6.547   5.816   -16.404 1.000 36.178 0 122 PHE A CB    1 ? 
ATOM   969  C  CG    . PHE A 1 122 ? 6.766   4.399   -15.960 1.000 36.974 0 122 PHE A CG    1 ? 
ATOM   970  C  CD1   . PHE A 1 122 ? 7.093   4.107   -14.645 1.000 37.501 0 122 PHE A CD1   1 ? 
ATOM   971  C  CD2   . PHE A 1 122 ? 6.641   3.354   -16.859 1.000 40.166 0 122 PHE A CD2   1 ? 
ATOM   972  C  CE1   . PHE A 1 122 ? 7.316   2.798   -14.247 1.000 41.331 0 122 PHE A CE1   1 ? 
ATOM   973  C  CE2   . PHE A 1 122 ? 6.860   2.046   -16.461 1.000 41.415 0 122 PHE A CE2   1 ? 
ATOM   974  C  CZ    . PHE A 1 122 ? 7.199   1.770   -15.157 1.000 41.687 0 122 PHE A CZ    1 ? 
ATOM   975  N  N     . LYS A 1 123 ? 4.883   8.653   -15.826 1.000 36.237 0 123 LYS A N     1 ? 
ATOM   976  C  CA    . LYS A 1 123 ? 4.940   10.113  -16.064 1.000 37.601 0 123 LYS A CA    1 ? 
ATOM   977  C  C     . LYS A 1 123 ? 6.012   10.683  -15.146 1.000 36.499 0 123 LYS A C     1 ? 
ATOM   978  O  O     . LYS A 1 123 ? 6.468   9.997   -14.218 1.000 28.799 0 123 LYS A O     1 ? 
ATOM   979  C  CB    . LYS A 1 123 ? 3.573   10.750  -15.803 1.000 41.360 0 123 LYS A CB    1 ? 
ATOM   980  C  CG    . LYS A 1 123 ? 2.624   10.750  -16.991 1.000 48.799 0 123 LYS A CG    1 ? 
ATOM   981  C  CD    . LYS A 1 123 ? 2.753   11.988  -17.839 1.000 52.761 0 123 LYS A CD    1 ? 
ATOM   982  C  CE    . LYS A 1 123 ? 1.553   12.251  -18.717 1.000 55.245 0 123 LYS A CE    1 ? 
ATOM   983  N  NZ    . LYS A 1 123 ? 1.610   13.617  -19.289 1.000 54.606 0 123 LYS A NZ    1 ? 
ATOM   984  N  N     . PRO A 1 124 ? 6.472   11.936  -15.389 1.000 39.576 0 124 PRO A N     1 ? 
ATOM   985  C  CA    . PRO A 1 124 ? 7.406   12.595  -14.482 1.000 37.053 0 124 PRO A CA    1 ? 
ATOM   986  C  C     . PRO A 1 124 ? 6.784   12.742  -13.088 1.000 31.083 0 124 PRO A C     1 ? 
ATOM   987  O  O     . PRO A 1 124 ? 5.797   13.470  -12.944 1.000 30.045 0 124 PRO A O     1 ? 
ATOM   988  C  CB    . PRO A 1 124 ? 7.690   13.968  -15.141 1.000 40.125 0 124 PRO A CB    1 ? 
ATOM   989  C  CG    . PRO A 1 124 ? 7.226   13.800  -16.589 1.000 41.607 0 124 PRO A CG    1 ? 
ATOM   990  C  CD    . PRO A 1 124 ? 6.095   12.790  -16.526 1.000 41.228 0 124 PRO A CD    1 ? 
ATOM   991  N  N     . GLY A 1 125 ? 7.338   12.011  -12.115 1.000 31.135 0 125 GLY A N     1 ? 
ATOM   992  C  CA    . GLY A 1 125 ? 7.018   12.162  -10.682 1.000 30.744 0 125 GLY A CA    1 ? 
ATOM   993  C  C     . GLY A 1 125 ? 5.856   11.275  -10.244 1.000 29.979 0 125 GLY A C     1 ? 
ATOM   994  O  O     . GLY A 1 125 ? 5.503   11.318  -9.043  1.000 28.372 0 125 GLY A O     1 ? 
ATOM   995  N  N     . TYR A 1 126 ? 5.249   10.520  -11.153 1.000 29.896 0 126 TYR A N     1 ? 
ATOM   996  C  CA    . TYR A 1 126 ? 4.183   9.550   -10.786 1.000 26.594 0 126 TYR A CA    1 ? 
ATOM   997  C  C     . TYR A 1 126 ? 4.091   8.434   -11.807 1.000 25.775 0 126 TYR A C     1 ? 
ATOM   998  O  O     . TYR A 1 126 ? 4.346   8.662   -12.996 1.000 29.753 0 126 TYR A O     1 ? 
ATOM   999  C  CB    . TYR A 1 126 ? 2.851   10.267  -10.571 1.000 28.358 0 126 TYR A CB    1 ? 
ATOM   1000 C  CG    . TYR A 1 126 ? 2.151   10.821  -11.786 1.000 30.483 0 126 TYR A CG    1 ? 
ATOM   1001 C  CD1   . TYR A 1 126 ? 2.314   12.150  -12.164 1.000 33.753 0 126 TYR A CD1   1 ? 
ATOM   1002 C  CD2   . TYR A 1 126 ? 1.202   10.070  -12.470 1.000 31.241 0 126 TYR A CD2   1 ? 
ATOM   1003 C  CE1   . TYR A 1 126 ? 1.601   12.694  -13.229 1.000 34.905 0 126 TYR A CE1   1 ? 
ATOM   1004 C  CE2   . TYR A 1 126 ? 0.481   10.601  -13.533 1.000 32.674 0 126 TYR A CE2   1 ? 
ATOM   1005 C  CZ    . TYR A 1 126 ? 0.691   11.911  -13.926 1.000 33.923 0 126 TYR A CZ    1 ? 
ATOM   1006 O  OH    . TYR A 1 126 ? -0.022  12.438  -14.981 1.000 33.891 0 126 TYR A OH    1 ? 
ATOM   1007 N  N     . HIS A 1 127 ? 3.641   7.261   -11.344 1.000 23.419 0 127 HIS A N     1 ? 
ATOM   1008 C  CA    . HIS A 1 127 ? 3.189   6.157   -12.210 1.000 23.953 0 127 HIS A CA    1 ? 
ATOM   1009 C  C     . HIS A 1 127 ? 1.735   5.819   -11.898 1.000 23.158 0 127 HIS A C     1 ? 
ATOM   1010 O  O     . HIS A 1 127 ? 1.233   6.150   -10.773 1.000 20.117 0 127 HIS A O     1 ? 
ATOM   1011 C  CB    . HIS A 1 127 ? 4.111   4.965   -12.078 1.000 26.869 0 127 HIS A CB    1 ? 
ATOM   1012 C  CG    . HIS A 1 127 ? 4.251   4.448   -10.694 1.000 28.415 0 127 HIS A CG    1 ? 
ATOM   1013 N  ND1   . HIS A 1 127 ? 5.227   4.904   -9.829  1.000 28.347 0 127 HIS A ND1   1 ? 
ATOM   1014 C  CD2   . HIS A 1 127 ? 3.548   3.513   -10.016 1.000 26.794 0 127 HIS A CD2   1 ? 
ATOM   1015 C  CE1   . HIS A 1 127 ? 5.102   4.285   -8.683  1.000 28.194 0 127 HIS A CE1   1 ? 
ATOM   1016 N  NE2   . HIS A 1 127 ? 4.088   3.425   -8.780  1.000 27.466 0 127 HIS A NE2   1 ? 
ATOM   1017 N  N     . VAL A 1 128 ? 1.069   5.246   -12.879 1.000 20.993 0 128 VAL A N     1 ? 
ATOM   1018 C  CA    . VAL A 1 128 ? -0.331  4.786   -12.783 1.000 20.604 0 128 VAL A CA    1 ? 
ATOM   1019 C  C     . VAL A 1 128 ? -0.327  3.276   -12.978 1.000 21.655 0 128 VAL A C     1 ? 
ATOM   1020 O  O     . VAL A 1 128 ? 0.205   2.801   -13.992 1.000 21.224 0 128 VAL A O     1 ? 
ATOM   1021 C  CB    . VAL A 1 128 ? -1.242  5.497   -13.790 1.000 20.296 0 128 VAL A CB    1 ? 
ATOM   1022 C  CG1   . VAL A 1 128 ? -2.658  4.964   -13.730 1.000 21.837 0 128 VAL A CG1   1 ? 
ATOM   1023 C  CG2   . VAL A 1 128 ? -1.211  7.009   -13.627 1.000 21.234 0 128 VAL A CG2   1 ? 
ATOM   1024 N  N     . ASP A 1 129 ? -0.816  2.555   -11.985 1.000 18.943 0 129 ASP A N     1 ? 
ATOM   1025 C  CA    . ASP A 1 129 ? -0.909  1.088   -11.985 1.000 18.548 0 129 ASP A CA    1 ? 
ATOM   1026 C  C     . ASP A 1 129 ? -2.350  0.751   -12.306 1.000 20.919 0 129 ASP A C     1 ? 
ATOM   1027 O  O     . ASP A 1 129 ? -3.237  0.984   -11.422 1.000 17.222 0 129 ASP A O     1 ? 
ATOM   1028 C  CB    . ASP A 1 129 ? -0.490  0.475   -10.641 1.000 20.950 0 129 ASP A CB    1 ? 
ATOM   1029 C  CG    . ASP A 1 129 ? 0.972   0.650   -10.320 1.000 24.544 0 129 ASP A CG    1 ? 
ATOM   1030 O  OD1   . ASP A 1 129 ? 1.731   1.039   -11.231 1.000 23.395 0 129 ASP A OD1   1 ? 
ATOM   1031 O  OD2   . ASP A 1 129 ? 1.334   0.422   -9.160  1.000 20.248 0 129 ASP A OD2   1 ? 
ATOM   1032 N  N     . LEU A 1 130 ? -2.602  0.227   -13.513 1.000 17.961 0 130 LEU A N     1 ? 
ATOM   1033 C  CA    . LEU A 1 130 ? -3.944  -0.247  -13.913 1.000 18.341 0 130 LEU A CA    1 ? 
ATOM   1034 C  C     . LEU A 1 130 ? -4.040  -1.741  -13.676 1.000 17.205 0 130 LEU A C     1 ? 
ATOM   1035 O  O     . LEU A 1 130 ? -3.440  -2.530  -14.427 1.000 17.542 0 130 LEU A O     1 ? 
ATOM   1036 C  CB    . LEU A 1 130 ? -4.221  0.072   -15.377 1.000 21.534 0 130 LEU A CB    1 ? 
ATOM   1037 C  CG    . LEU A 1 130 ? -4.018  1.515   -15.768 1.000 23.354 0 130 LEU A CG    1 ? 
ATOM   1038 C  CD1   . LEU A 1 130 ? -2.630  1.724   -16.336 1.000 27.028 0 130 LEU A CD1   1 ? 
ATOM   1039 C  CD2   . LEU A 1 130 ? -5.079  1.934   -16.748 1.000 27.534 0 130 LEU A CD2   1 ? 
ATOM   1040 N  N     . ALA A 1 131 ? -4.843  -2.126  -12.726 1.000 14.136 0 131 ALA A N     1 ? 
ATOM   1041 C  CA    . ALA A 1 131 ? -5.293  -3.505  -12.523 1.000 14.847 0 131 ALA A CA    1 ? 
ATOM   1042 C  C     . ALA A 1 131 ? -6.410  -3.774  -13.520 1.000 15.891 0 131 ALA A C     1 ? 
ATOM   1043 O  O     . ALA A 1 131 ? -7.332  -2.916  -13.670 1.000 14.949 0 131 ALA A O     1 ? 
ATOM   1044 C  CB    . ALA A 1 131 ? -5.762  -3.720  -11.116 1.000 15.396 0 131 ALA A CB    1 ? 
ATOM   1045 N  N     . VAL A 1 132 ? -6.269  -4.869  -14.256 1.000 17.332 0 132 VAL A N     1 ? 
ATOM   1046 C  CA    . VAL A 1 132 ? -7.151  -5.203  -15.401 1.000 18.016 0 132 VAL A CA    1 ? 
ATOM   1047 C  C     . VAL A 1 132 ? -8.010  -6.407  -15.052 1.000 14.736 0 132 VAL A C     1 ? 
ATOM   1048 O  O     . VAL A 1 132 ? -7.461  -7.462  -14.703 1.000 17.020 0 132 VAL A O     1 ? 
ATOM   1049 C  CB    . VAL A 1 132 ? -6.292  -5.454  -16.639 1.000 18.590 0 132 VAL A CB    1 ? 
ATOM   1050 C  CG1   . VAL A 1 132 ? -7.148  -5.890  -17.804 1.000 19.401 0 132 VAL A CG1   1 ? 
ATOM   1051 C  CG2   . VAL A 1 132 ? -5.466  -4.237  -16.978 1.000 19.802 0 132 VAL A CG2   1 ? 
ATOM   1052 N  N     . TYR A 1 133 ? -9.338  -6.256  -15.125 1.000 15.988 0 133 TYR A N     1 ? 
ATOM   1053 C  CA    . TYR A 1 133 ? -10.314 -7.288  -14.726 1.000 15.755 0 133 TYR A CA    1 ? 
ATOM   1054 C  C     . TYR A 1 133 ? -11.230 -7.611  -15.906 1.000 15.684 0 133 TYR A C     1 ? 
ATOM   1055 O  O     . TYR A 1 133 ? -11.524 -6.707  -16.703 1.000 17.635 0 133 TYR A O     1 ? 
ATOM   1056 C  CB    . TYR A 1 133 ? -11.169 -6.821  -13.529 1.000 15.662 0 133 TYR A CB    1 ? 
ATOM   1057 C  CG    . TYR A 1 133 ? -10.365 -6.335  -12.343 1.000 14.319 0 133 TYR A CG    1 ? 
ATOM   1058 C  CD1   . TYR A 1 133 ? -9.955  -5.022  -12.274 1.000 14.758 0 133 TYR A CD1   1 ? 
ATOM   1059 C  CD2   . TYR A 1 133 ? -10.033 -7.186  -11.320 1.000 13.715 0 133 TYR A CD2   1 ? 
ATOM   1060 C  CE1   . TYR A 1 133 ? -9.249  -4.551  -11.170 1.000 14.172 0 133 TYR A CE1   1 ? 
ATOM   1061 C  CE2   . TYR A 1 133 ? -9.298  -6.745  -10.231 1.000 14.775 0 133 TYR A CE2   1 ? 
ATOM   1062 C  CZ    . TYR A 1 133 ? -8.912  -5.430  -10.169 1.000 14.654 0 133 TYR A CZ    1 ? 
ATOM   1063 O  OH    . TYR A 1 133 ? -8.206  -5.017  -9.059  1.000 14.042 0 133 TYR A OH    1 ? 
ATOM   1064 N  N     . ALA A 1 134 ? -11.703 -8.838  -15.931 1.000 19.150 0 134 ALA A N     1 ? 
ATOM   1065 C  CA    . ALA A 1 134 ? -12.830 -9.273  -16.774 1.000 19.734 0 134 ALA A CA    1 ? 
ATOM   1066 C  C     . ALA A 1 134 ? -14.149 -8.858  -16.131 1.000 22.071 0 134 ALA A C     1 ? 
ATOM   1067 O  O     . ALA A 1 134 ? -14.203 -8.670  -14.894 1.000 19.645 0 134 ALA A O     1 ? 
ATOM   1068 C  CB    . ALA A 1 134 ? -12.754 -10.743 -16.972 1.000 20.666 0 134 ALA A CB    1 ? 
ATOM   1069 N  N     . ASP A 1 135 ? -15.213 -8.780  -16.928 1.000 19.832 0 135 ASP A N     1 ? 
ATOM   1070 C  CA    . ASP A 1 135 ? -16.566 -8.429  -16.439 1.000 21.303 0 135 ASP A CA    1 ? 
ATOM   1071 C  C     . ASP A 1 135 ? -17.133 -9.604  -15.649 1.000 21.343 0 135 ASP A C     1 ? 
ATOM   1072 O  O     . ASP A 1 135 ? -17.357 -10.684 -16.209 1.000 23.450 0 135 ASP A O     1 ? 
ATOM   1073 C  CB    . ASP A 1 135 ? -17.470 -8.061  -17.615 1.000 23.973 0 135 ASP A CB    1 ? 
ATOM   1074 C  CG    . ASP A 1 135 ? -18.848 -7.531  -17.250 1.000 26.661 0 135 ASP A CG    1 ? 
ATOM   1075 O  OD1   . ASP A 1 135 ? -19.333 -7.835  -16.150 1.000 26.586 0 135 ASP A OD1   1 ? 
ATOM   1076 O  OD2   . ASP A 1 135 ? -19.462 -6.882  -18.116 1.000 29.713 0 135 ASP A OD2   1 ? 
ATOM   1077 N  N     . PRO A 1 136 ? -17.466 -9.445  -14.351 1.000 21.516 0 136 PRO A N     1 ? 
ATOM   1078 C  CA    . PRO A 1 136 ? -18.098 -10.512 -13.597 1.000 21.481 0 136 PRO A CA    1 ? 
ATOM   1079 C  C     . PRO A 1 136 ? -19.345 -11.095 -14.276 1.000 25.170 0 136 PRO A C     1 ? 
ATOM   1080 O  O     . PRO A 1 136 ? -19.576 -12.293 -14.152 1.000 26.644 0 136 PRO A O     1 ? 
ATOM   1081 C  CB    . PRO A 1 136 ? -18.509 -9.822  -12.274 1.000 22.470 0 136 PRO A CB    1 ? 
ATOM   1082 C  CG    . PRO A 1 136 ? -17.498 -8.718  -12.113 1.000 21.139 0 136 PRO A CG    1 ? 
ATOM   1083 C  CD    . PRO A 1 136 ? -17.171 -8.265  -13.519 1.000 21.145 0 136 PRO A CD    1 ? 
ATOM   1084 N  N     . GLU A 1 137 ? -20.149 -10.238 -14.894 1.000 26.740 0 137 GLU A N     1 ? 
ATOM   1085 C  CA    . GLU A 1 137 ? -21.503 -10.619 -15.385 1.000 33.687 0 137 GLU A CA    1 ? 
ATOM   1086 C  C     . GLU A 1 137 ? -21.347 -11.538 -16.599 1.000 35.152 0 137 GLU A C     1 ? 
ATOM   1087 O  O     . GLU A 1 137 ? -22.334 -12.162 -16.990 1.000 35.462 0 137 GLU A O     1 ? 
ATOM   1088 C  CB    . GLU A 1 137 ? -22.337 -9.377  -15.701 1.000 39.257 0 137 GLU A CB    1 ? 
ATOM   1089 C  CG    . GLU A 1 137 ? -23.278 -8.995  -14.566 1.000 45.451 0 137 GLU A CG    1 ? 
ATOM   1090 C  CD    . GLU A 1 137 ? -24.204 -10.128 -14.146 1.000 52.383 0 137 GLU A CD    1 ? 
ATOM   1091 O  OE1   . GLU A 1 137 ? -25.029 -10.554 -14.982 1.000 59.884 0 137 GLU A OE1   1 ? 
ATOM   1092 O  OE2   . GLU A 1 137 ? -24.051 -10.629 -13.007 1.000 59.827 0 137 GLU A OE2   1 ? 
ATOM   1093 N  N     . LEU A 1 138 ? -20.146 -11.582 -17.170 1.000 28.816 0 138 LEU A N     1 ? 
ATOM   1094 C  CA    . LEU A 1 138 ? -19.811 -12.389 -18.363 1.000 28.204 0 138 LEU A CA    1 ? 
ATOM   1095 C  C     . LEU A 1 138 ? -18.867 -13.520 -17.975 1.000 30.845 0 138 LEU A C     1 ? 
ATOM   1096 O  O     . LEU A 1 138 ? -18.464 -14.272 -18.889 1.000 31.132 0 138 LEU A O     1 ? 
ATOM   1097 C  CB    . LEU A 1 138 ? -19.139 -11.499 -19.407 1.000 27.233 0 138 LEU A CB    1 ? 
ATOM   1098 C  CG    . LEU A 1 138 ? -19.953 -10.317 -19.915 1.000 27.523 0 138 LEU A CG    1 ? 
ATOM   1099 C  CD1   . LEU A 1 138 ? -19.148 -9.532  -20.929 1.000 25.103 0 138 LEU A CD1   1 ? 
ATOM   1100 C  CD2   . LEU A 1 138 ? -21.260 -10.784 -20.532 1.000 28.443 0 138 LEU A CD2   1 ? 
ATOM   1101 N  N     . SER A 1 139 ? -18.423 -13.576 -16.709 1.000 25.988 0 139 SER A N     1 ? 
ATOM   1102 C  CA    . SER A 1 139 ? -17.325 -14.481 -16.275 1.000 26.179 0 139 SER A CA    1 ? 
ATOM   1103 C  C     . SER A 1 139 ? -17.765 -15.303 -15.065 1.000 27.909 0 139 SER A C     1 ? 
ATOM   1104 O  O     . SER A 1 139 ? -16.926 -15.555 -14.186 1.000 35.984 0 139 SER A O     1 ? 
ATOM   1105 C  CB    . SER A 1 139 ? -16.053 -13.713 -15.984 1.000 23.360 0 139 SER A CB    1 ? 
ATOM   1106 O  OG    . SER A 1 139 ? -15.803 -12.725 -16.959 1.000 21.328 0 139 SER A OG    1 ? 
ATOM   1107 N  N     . GLY A 1 140 ? -19.044 -15.683 -15.011 1.000 31.752 0 140 GLY A N     1 ? 
ATOM   1108 C  CA    . GLY A 1 140 ? -19.565 -16.655 -14.036 1.000 34.671 0 140 GLY A CA    1 ? 
ATOM   1109 C  C     . GLY A 1 140 ? -19.804 -16.020 -12.673 1.000 34.596 0 140 GLY A C     1 ? 
ATOM   1110 O  O     . GLY A 1 140 ? -19.956 -16.773 -11.701 1.000 36.151 0 140 GLY A O     1 ? 
ATOM   1111 N  N     . GLY A 1 141 ? -19.868 -14.680 -12.610 1.000 33.009 0 141 GLY A N     1 ? 
ATOM   1112 C  CA    . GLY A 1 141 ? -20.231 -13.929 -11.389 1.000 32.847 0 141 GLY A CA    1 ? 
ATOM   1113 C  C     . GLY A 1 141 ? -19.013 -13.547 -10.553 1.000 32.583 0 141 GLY A C     1 ? 
ATOM   1114 O  O     . GLY A 1 141 ? -19.208 -12.869 -9.510  1.000 29.653 0 141 GLY A O     1 ? 
ATOM   1115 N  N     . THR A 1 142 ? -17.806 -13.921 -11.001 1.000 31.448 0 142 THR A N     1 ? 
ATOM   1116 C  CA    . THR A 1 142 ? -16.516 -13.682 -10.290 1.000 28.912 0 142 THR A CA    1 ? 
ATOM   1117 C  C     . THR A 1 142 ? -15.806 -12.447 -10.885 1.000 24.990 0 142 THR A C     1 ? 
ATOM   1118 O  O     . THR A 1 142 ? -15.842 -12.266 -12.088 1.000 26.474 0 142 THR A O     1 ? 
ATOM   1119 C  CB    . THR A 1 142 ? -15.620 -14.933 -10.336 1.000 31.815 0 142 THR A CB    1 ? 
ATOM   1120 O  OG1   . THR A 1 142 ? -15.021 -15.018 -11.633 1.000 37.105 0 142 THR A OG1   1 ? 
ATOM   1121 C  CG2   . THR A 1 142 ? -16.380 -16.215 -10.056 1.000 35.910 0 142 THR A CG2   1 ? 
ATOM   1122 N  N     . LEU A 1 143 ? -15.158 -11.642 -10.043 1.000 20.596 0 143 LEU A N     1 ? 
ATOM   1123 C  CA    . LEU A 1 143 ? -14.234 -10.575 -10.483 1.000 18.491 0 143 LEU A CA    1 ? 
ATOM   1124 C  C     . LEU A 1 143 ? -12.798 -11.083 -10.505 1.000 20.258 0 143 LEU A C     1 ? 
ATOM   1125 O  O     . LEU A 1 143 ? -12.255 -11.392 -9.428  1.000 18.506 0 143 LEU A O     1 ? 
ATOM   1126 C  CB    . LEU A 1 143 ? -14.350 -9.365  -9.564  1.000 18.451 0 143 LEU A CB    1 ? 
ATOM   1127 C  CG    . LEU A 1 143 ? -13.505 -8.162  -9.986  1.000 17.396 0 143 LEU A CG    1 ? 
ATOM   1128 C  CD1   . LEU A 1 143 ? -14.056 -7.464  -11.235 1.000 18.989 0 143 LEU A CD1   1 ? 
ATOM   1129 C  CD2   . LEU A 1 143 ? -13.408 -7.158  -8.837  1.000 20.090 0 143 LEU A CD2   1 ? 
ATOM   1130 N  N     . CYS A 1 144 ? -12.197 -11.180 -11.682 1.000 18.973 0 144 CYS A N     1 ? 
ATOM   1131 C  CA    . CYS A 1 144 ? -10.865 -11.780 -11.831 1.000 19.302 0 144 CYS A CA    1 ? 
ATOM   1132 C  C     . CYS A 1 144 ? -9.917  -10.792 -12.456 1.000 16.874 0 144 CYS A C     1 ? 
ATOM   1133 O  O     . CYS A 1 144 ? -10.301 -10.121 -13.435 1.000 16.861 0 144 CYS A O     1 ? 
ATOM   1134 C  CB    . CYS A 1 144 ? -10.910 -13.024 -12.697 1.000 18.901 0 144 CYS A CB    1 ? 
ATOM   1135 S  SG    . CYS A 1 144 ? -11.917 -14.319 -11.977 1.000 25.112 0 144 CYS A SG    1 ? 
ATOM   1136 N  N     . ILE A 1 145 ? -8.695  -10.743 -11.913 1.000 16.584 0 145 ILE A N     1 ? 
ATOM   1137 C  CA    . ILE A 1 145 ? -7.615  -9.851  -12.365 1.000 15.975 0 145 ILE A CA    1 ? 
ATOM   1138 C  C     . ILE A 1 145 ? -6.692  -10.624 -13.315 1.000 15.585 0 145 ILE A C     1 ? 
ATOM   1139 O  O     . ILE A 1 145 ? -6.568  -11.841 -13.127 1.000 18.134 0 145 ILE A O     1 ? 
ATOM   1140 C  CB    . ILE A 1 145 ? -6.860  -9.267  -11.135 1.000 15.967 0 145 ILE A CB    1 ? 
ATOM   1141 C  CG1   . ILE A 1 145 ? -5.945  -8.122  -11.541 1.000 16.686 0 145 ILE A CG1   1 ? 
ATOM   1142 C  CG2   . ILE A 1 145 ? -6.141  -10.367 -10.342 1.000 19.063 0 145 ILE A CG2   1 ? 
ATOM   1143 C  CD1   . ILE A 1 145 ? -5.349  -7.305  -10.369 1.000 16.299 0 145 ILE A CD1   1 ? 
ATOM   1144 N  N     . ALA A 1 146 ? -6.183  -9.936  -14.309 1.000 18.045 0 146 ALA A N     1 ? 
ATOM   1145 C  CA    . ALA A 1 146 ? -5.268  -10.464 -15.342 1.000 18.993 0 146 ALA A CA    1 ? 
ATOM   1146 C  C     . ALA A 1 146 ? -3.879  -10.600 -14.728 1.000 17.986 0 146 ALA A C     1 ? 
ATOM   1147 O  O     . ALA A 1 146 ? -3.219  -9.600  -14.591 1.000 17.685 0 146 ALA A O     1 ? 
ATOM   1148 C  CB    . ALA A 1 146 ? -5.267  -9.555  -16.533 1.000 18.760 0 146 ALA A CB    1 ? 
ATOM   1149 N  N     . LYS A 1 147 ? -3.461  -11.829 -14.434 1.000 21.723 0 147 LYS A N     1 ? 
ATOM   1150 C  CA    . LYS A 1 147 ? -2.133  -12.136 -13.862 1.000 22.064 0 147 LYS A CA    1 ? 
ATOM   1151 C  C     . LYS A 1 147 ? -1.215  -12.721 -14.935 1.000 24.202 0 147 LYS A C     1 ? 
ATOM   1152 O  O     . LYS A 1 147 ? -1.684  -13.509 -15.735 1.000 26.808 0 147 LYS A O     1 ? 
ATOM   1153 C  CB    . LYS A 1 147 ? -2.253  -13.153 -12.734 1.000 26.158 0 147 LYS A CB    1 ? 
ATOM   1154 C  CG    . LYS A 1 147 ? -3.063  -12.667 -11.547 1.000 30.240 0 147 LYS A CG    1 ? 
ATOM   1155 C  CD    . LYS A 1 147 ? -2.246  -11.897 -10.562 1.000 36.776 0 147 LYS A CD    1 ? 
ATOM   1156 C  CE    . LYS A 1 147 ? -1.409  -12.795 -9.690  1.000 42.317 0 147 LYS A CE    1 ? 
ATOM   1157 N  NZ    . LYS A 1 147 ? -0.849  -12.047 -8.548  1.000 46.908 0 147 LYS A NZ    1 ? 
ATOM   1158 N  N     . GLY A 1 148 ? 0.071   -12.413 -14.836 1.000 25.848 0 148 GLY A N     1 ? 
ATOM   1159 C  CA    . GLY A 1 148 ? 1.127   -12.992 -15.688 1.000 27.757 0 148 GLY A CA    1 ? 
ATOM   1160 C  C     . GLY A 1 148 ? 1.847   -11.914 -16.466 1.000 27.546 0 148 GLY A C     1 ? 
ATOM   1161 O  O     . GLY A 1 148 ? 1.256   -10.865 -16.701 1.000 26.549 0 148 GLY A O     1 ? 
ATOM   1162 N  N     . LYS A 1 149 ? 3.090   -12.186 -16.871 1.000 29.157 0 149 LYS A N     1 ? 
ATOM   1163 C  CA    . LYS A 1 149 ? 3.892   -11.304 -17.738 1.000 35.883 0 149 LYS A CA    1 ? 
ATOM   1164 C  C     . LYS A 1 149 ? 4.031   -11.976 -19.113 1.000 31.164 0 149 LYS A C     1 ? 
ATOM   1165 O  O     . LYS A 1 149 ? 3.598   -13.141 -19.254 1.000 29.948 0 149 LYS A O     1 ? 
ATOM   1166 C  CB    . LYS A 1 149 ? 5.236   -11.004 -17.059 1.000 39.330 0 149 LYS A CB    1 ? 
ATOM   1167 C  CG    . LYS A 1 149 ? 5.179   -9.923  -15.982 1.000 44.296 0 149 LYS A CG    1 ? 
ATOM   1168 C  CD    . LYS A 1 149 ? 6.474   -9.144  -15.803 1.000 50.180 0 149 LYS A CD    1 ? 
ATOM   1169 C  CE    . LYS A 1 149 ? 7.307   -9.651  -14.649 1.000 55.389 0 149 LYS A CE    1 ? 
ATOM   1170 N  NZ    . LYS A 1 149 ? 7.579   -11.101 -14.775 1.000 55.472 0 149 LYS A NZ    1 ? 
ATOM   1171 N  N     . GLU A 1 150 ? 4.517   -11.221 -20.096 1.000 40.676 0 150 GLU A N     1 ? 
ATOM   1172 C  CA    . GLU A 1 150 ? 4.769   -11.687 -21.489 1.000 45.573 0 150 GLU A CA    1 ? 
ATOM   1173 C  C     . GLU A 1 150 ? 5.682   -12.907 -21.431 1.000 44.873 0 150 GLU A C     1 ? 
ATOM   1174 O  O     . GLU A 1 150 ? 5.352   -13.941 -22.064 1.000 40.744 0 150 GLU A O     1 ? 
ATOM   1175 C  CB    . GLU A 1 150 ? 5.397   -10.563 -22.310 1.000 48.128 0 150 GLU A CB    1 ? 
ATOM   1176 C  CG    . GLU A 1 150 ? 4.576   -9.290  -22.292 1.000 49.671 0 150 GLU A CG    1 ? 
ATOM   1177 C  CD    . GLU A 1 150 ? 5.193   -8.147  -23.061 1.000 54.320 0 150 GLU A CD    1 ? 
ATOM   1178 O  OE1   . GLU A 1 150 ? 5.110   -8.168  -24.309 1.000 56.341 0 150 GLU A OE1   1 ? 
ATOM   1179 O  OE2   . GLU A 1 150 ? 5.761   -7.235  -22.407 1.000 58.425 0 150 GLU A OE2   1 ? 
ATOM   1180 N  N     . ASN A 1 151 ? 6.745   -12.792 -20.637 1.000 45.980 0 151 ASN A N     1 ? 
ATOM   1181 C  CA    . ASN A 1 151 ? 7.678   -13.883 -20.272 1.000 54.341 0 151 ASN A CA    1 ? 
ATOM   1182 C  C     . ASN A 1 151 ? 7.180   -14.519 -18.966 1.000 59.899 0 151 ASN A C     1 ? 
ATOM   1183 O  O     . ASN A 1 151 ? 7.828   -14.297 -17.919 1.000 63.045 0 151 ASN A O     1 ? 
ATOM   1184 C  CB    . ASN A 1 151 ? 9.106   -13.337 -20.184 1.000 56.483 0 151 ASN A CB    1 ? 
ATOM   1185 C  CG    . ASN A 1 151 ? 10.116  -14.358 -19.729 1.000 63.667 0 151 ASN A CG    1 ? 
ATOM   1186 O  OD1   . ASN A 1 151 ? 10.113  -15.493 -20.201 1.000 70.172 0 151 ASN A OD1   1 ? 
ATOM   1187 N  ND2   . ASN A 1 151 ? 11.006  -13.952 -18.834 1.000 64.055 0 151 ASN A ND2   1 ? 
ATOM   1188 N  N     . SER A 1 152 ? 5.987   -15.133 -19.016 1.000 56.712 0 152 SER A N     1 ? 
ATOM   1189 C  CA    . SER A 1 152 ? 5.404   -16.032 -17.977 1.000 55.446 0 152 SER A CA    1 ? 
ATOM   1190 C  C     . SER A 1 152 ? 4.980   -17.339 -18.644 1.000 58.727 0 152 SER A C     1 ? 
ATOM   1191 O  O     . SER A 1 152 ? 4.464   -17.276 -19.789 1.000 62.028 0 152 SER A O     1 ? 
ATOM   1192 C  CB    . SER A 1 152 ? 4.206   -15.399 -17.271 1.000 50.174 0 152 SER A CB    1 ? 
ATOM   1193 O  OG    . SER A 1 152 ? 4.590   -14.287 -16.481 1.000 43.054 0 152 SER A OG    1 ? 
ATOM   1194 N  N     . GLY A 1 153 ? 5.119   -18.462 -17.934 1.000 63.719 0 153 GLY A N     1 ? 
ATOM   1195 C  CA    . GLY A 1 153 ? 4.616   -19.781 -18.371 1.000 64.096 0 153 GLY A CA    1 ? 
ATOM   1196 C  C     . GLY A 1 153 ? 3.105   -19.869 -18.251 1.000 66.601 0 153 GLY A C     1 ? 
ATOM   1197 O  O     . GLY A 1 153 ? 2.535   -19.119 -17.434 1.000 60.299 0 153 GLY A O     1 ? 
ATOM   1198 N  N     . ASP A 1 154 ? 2.482   -20.778 -19.007 1.000 68.613 0 154 ASP A N     1 ? 
ATOM   1199 C  CA    . ASP A 1 154 ? 1.005   -20.976 -19.045 1.000 73.664 0 154 ASP A CA    1 ? 
ATOM   1200 C  C     . ASP A 1 154 ? 0.456   -21.047 -17.610 1.000 73.937 0 154 ASP A C     1 ? 
ATOM   1201 O  O     . ASP A 1 154 ? -0.600  -20.444 -17.361 1.000 74.918 0 154 ASP A O     1 ? 
ATOM   1202 C  CB    . ASP A 1 154 ? 0.632   -22.222 -19.854 1.000 77.135 0 154 ASP A CB    1 ? 
ATOM   1203 C  CG    . ASP A 1 154 ? 1.114   -22.184 -21.297 1.000 83.625 0 154 ASP A CG    1 ? 
ATOM   1204 O  OD1   . ASP A 1 154 ? 1.206   -21.071 -21.858 1.000 88.518 0 154 ASP A OD1   1 ? 
ATOM   1205 O  OD2   . ASP A 1 154 ? 1.396   -23.265 -21.848 1.000 89.626 0 154 ASP A OD2   1 ? 
ATOM   1206 N  N     . GLU A 1 155 ? 1.165   -21.736 -16.704 1.000 71.421 0 155 GLU A N     1 ? 
ATOM   1207 C  CA    . GLU A 1 155 ? 0.746   -21.971 -15.290 1.000 68.565 0 155 GLU A CA    1 ? 
ATOM   1208 C  C     . GLU A 1 155 ? 0.702   -20.643 -14.519 1.000 65.955 0 155 GLU A C     1 ? 
ATOM   1209 O  O     . GLU A 1 155 ? 0.015   -20.596 -13.477 1.000 64.399 0 155 GLU A O     1 ? 
ATOM   1210 C  CB    . GLU A 1 155 ? 1.695   -22.950 -14.589 1.000 69.427 0 155 GLU A CB    1 ? 
ATOM   1211 C  CG    . GLU A 1 155 ? 3.128   -22.449 -14.474 1.000 71.432 0 155 GLU A CG    1 ? 
ATOM   1212 C  CD    . GLU A 1 155 ? 4.059   -22.940 -15.568 1.000 70.988 0 155 GLU A CD    1 ? 
ATOM   1213 O  OE1   . GLU A 1 155 ? 5.058   -22.237 -15.861 1.000 66.668 0 155 GLU A OE1   1 ? 
ATOM   1214 O  OE2   . GLU A 1 155 ? 3.788   -24.022 -16.121 1.000 64.128 0 155 GLU A OE2   1 ? 
ATOM   1215 N  N     . HIS A 1 156 ? 1.439   -19.626 -14.986 1.000 67.723 0 156 HIS A N     1 ? 
ATOM   1216 C  CA    . HIS A 1 156 ? 1.638   -18.324 -14.288 1.000 64.617 0 156 HIS A CA    1 ? 
ATOM   1217 C  C     . HIS A 1 156 ? 0.741   -17.239 -14.889 1.000 60.448 0 156 HIS A C     1 ? 
ATOM   1218 O  O     . HIS A 1 156 ? 0.588   -16.192 -14.234 1.000 58.380 0 156 HIS A O     1 ? 
ATOM   1219 C  CB    . HIS A 1 156 ? 3.108   -17.905 -14.334 1.000 68.202 0 156 HIS A CB    1 ? 
ATOM   1220 C  CG    . HIS A 1 156 ? 3.996   -18.788 -13.534 1.000 74.616 0 156 HIS A CG    1 ? 
ATOM   1221 N  ND1   . HIS A 1 156 ? 3.687   -19.166 -12.239 1.000 74.537 0 156 HIS A ND1   1 ? 
ATOM   1222 C  CD2   . HIS A 1 156 ? 5.175   -19.375 -13.832 1.000 80.311 0 156 HIS A CD2   1 ? 
ATOM   1223 C  CE1   . HIS A 1 156 ? 4.637   -19.948 -11.776 1.000 79.546 0 156 HIS A CE1   1 ? 
ATOM   1224 N  NE2   . HIS A 1 156 ? 5.562   -20.093 -12.734 1.000 83.005 0 156 HIS A NE2   1 ? 
ATOM   1225 N  N     . ARG A 1 157 ? 0.200   -17.459 -16.091 1.000 51.397 0 157 ARG A N     1 ? 
ATOM   1226 C  CA    . ARG A 1 157 ? -0.795  -16.545 -16.706 1.000 50.962 0 157 ARG A CA    1 ? 
ATOM   1227 C  C     . ARG A 1 157 ? -2.190  -17.089 -16.388 1.000 43.614 0 157 ARG A C     1 ? 
ATOM   1228 O  O     . ARG A 1 157 ? -2.479  -18.229 -16.738 1.000 44.782 0 157 ARG A O     1 ? 
ATOM   1229 C  CB    . ARG A 1 157 ? -0.529  -16.335 -18.204 1.000 56.096 0 157 ARG A CB    1 ? 
ATOM   1230 C  CG    . ARG A 1 157 ? -0.506  -17.599 -19.048 1.000 64.418 0 157 ARG A CG    1 ? 
ATOM   1231 C  CD    . ARG A 1 157 ? -0.234  -17.274 -20.506 1.000 66.833 0 157 ARG A CD    1 ? 
ATOM   1232 N  NE    . ARG A 1 157 ? 1.033   -16.575 -20.687 1.000 68.534 0 157 ARG A NE    1 ? 
ATOM   1233 C  CZ    . ARG A 1 157 ? 1.314   -15.763 -21.707 1.000 72.151 0 157 ARG A CZ    1 ? 
ATOM   1234 N  NH1   . ARG A 1 157 ? 0.405   -15.521 -22.644 1.000 68.126 0 157 ARG A NH1   1 ? 
ATOM   1235 N  NH2   . ARG A 1 157 ? 2.505   -15.187 -21.780 1.000 75.658 0 157 ARG A NH2   1 ? 
ATOM   1236 N  N     . LEU A 1 158 ? -2.955  -16.355 -15.591 1.000 34.765 0 158 LEU A N     1 ? 
ATOM   1237 C  CA    . LEU A 1 158 ? -4.270  -16.808 -15.119 1.000 29.733 0 158 LEU A CA    1 ? 
ATOM   1238 C  C     . LEU A 1 158 ? -5.138  -15.600 -14.795 1.000 26.750 0 158 LEU A C     1 ? 
ATOM   1239 O  O     . LEU A 1 158 ? -4.588  -14.482 -14.649 1.000 25.691 0 158 LEU A O     1 ? 
ATOM   1240 C  CB    . LEU A 1 158 ? -4.087  -17.707 -13.900 1.000 34.166 0 158 LEU A CB    1 ? 
ATOM   1241 C  CG    . LEU A 1 158 ? -3.561  -17.015 -12.647 1.000 35.709 0 158 LEU A CG    1 ? 
ATOM   1242 C  CD1   . LEU A 1 158 ? -4.277  -17.533 -11.412 1.000 39.890 0 158 LEU A CD1   1 ? 
ATOM   1243 C  CD2   . LEU A 1 158 ? -2.055  -17.204 -12.519 1.000 36.443 0 158 LEU A CD2   1 ? 
ATOM   1244 N  N     . TRP A 1 159 ? -6.440  -15.804 -14.848 1.000 24.337 0 159 TRP A N     1 ? 
ATOM   1245 C  CA    . TRP A 1 159 ? -7.464  -14.894 -14.284 1.000 24.009 0 159 TRP A CA    1 ? 
ATOM   1246 C  C     . TRP A 1 159 ? -7.704  -15.286 -12.832 1.000 21.703 0 159 TRP A C     1 ? 
ATOM   1247 O  O     . TRP A 1 159 ? -8.236  -16.360 -12.589 1.000 28.758 0 159 TRP A O     1 ? 
ATOM   1248 C  CB    . TRP A 1 159 ? -8.754  -14.954 -15.108 1.000 21.715 0 159 TRP A CB    1 ? 
ATOM   1249 C  CG    . TRP A 1 159 ? -8.625  -14.413 -16.490 1.000 23.585 0 159 TRP A CG    1 ? 
ATOM   1250 C  CD1   . TRP A 1 159 ? -8.513  -15.145 -17.649 1.000 25.793 0 159 TRP A CD1   1 ? 
ATOM   1251 C  CD2   . TRP A 1 159 ? -8.691  -13.034 -16.896 1.000 21.738 0 159 TRP A CD2   1 ? 
ATOM   1252 N  NE1   . TRP A 1 159 ? -8.456  -14.320 -18.726 1.000 23.681 0 159 TRP A NE1   1 ? 
ATOM   1253 C  CE2   . TRP A 1 159 ? -8.584  -13.015 -18.310 1.000 23.769 0 159 TRP A CE2   1 ? 
ATOM   1254 C  CE3   . TRP A 1 159 ? -8.823  -11.811 -16.207 1.000 20.834 0 159 TRP A CE3   1 ? 
ATOM   1255 C  CZ2   . TRP A 1 159 ? -8.608  -11.832 -19.041 1.000 24.867 0 159 TRP A CZ2   1 ? 
ATOM   1256 C  CZ3   . TRP A 1 159 ? -8.821  -10.646 -16.926 1.000 22.094 0 159 TRP A CZ3   1 ? 
ATOM   1257 C  CH2   . TRP A 1 159 ? -8.710  -10.654 -18.331 1.000 24.780 0 159 TRP A CH2   1 ? 
ATOM   1258 N  N     . GLN A 1 160 ? -7.237  -14.471 -11.882 1.000 20.902 0 160 GLN A N     1 ? 
ATOM   1259 C  CA    . GLN A 1 160 ? -7.262  -14.814 -10.438 1.000 21.151 0 160 GLN A CA    1 ? 
ATOM   1260 C  C     . GLN A 1 160 ? -8.402  -14.048 -9.766  1.000 19.114 0 160 GLN A C     1 ? 
ATOM   1261 O  O     . GLN A 1 160 ? -8.515  -12.851 -10.013 1.000 20.159 0 160 GLN A O     1 ? 
ATOM   1262 C  CB    . GLN A 1 160 ? -5.926  -14.471 -9.782  1.000 25.129 0 160 GLN A CB    1 ? 
ATOM   1263 C  CG    . GLN A 1 160 ? -5.837  -14.850 -8.306  1.000 26.121 0 160 GLN A CG    1 ? 
ATOM   1264 C  CD    . GLN A 1 160 ? -4.612  -14.251 -7.649  1.000 27.668 0 160 GLN A CD    1 ? 
ATOM   1265 O  OE1   . GLN A 1 160 ? -4.133  -13.182 -8.025  1.000 37.996 0 160 GLN A OE1   1 ? 
ATOM   1266 N  NE2   . GLN A 1 160 ? -4.097  -14.928 -6.653  1.000 36.938 0 160 GLN A NE2   1 ? 
ATOM   1267 N  N     . ILE A 1 161 ? -9.229  -14.746 -9.011  1.000 20.572 0 161 ILE A N     1 ? 
ATOM   1268 C  CA    . ILE A 1 161 ? -10.300 -14.143 -8.183  1.000 19.267 0 161 ILE A CA    1 ? 
ATOM   1269 C  C     . ILE A 1 161 ? -9.648  -13.027 -7.356  1.000 18.522 0 161 ILE A C     1 ? 
ATOM   1270 O  O     . ILE A 1 161 ? -8.566  -13.261 -6.763  1.000 19.268 0 161 ILE A O     1 ? 
ATOM   1271 C  CB    . ILE A 1 161 ? -10.977 -15.200 -7.304  1.000 22.238 0 161 ILE A CB    1 ? 
ATOM   1272 C  CG1   . ILE A 1 161 ? -12.145 -14.637 -6.490  1.000 25.553 0 161 ILE A CG1   1 ? 
ATOM   1273 C  CG2   . ILE A 1 161 ? -9.961  -15.883 -6.413  1.000 23.818 0 161 ILE A CG2   1 ? 
ATOM   1274 C  CD1   . ILE A 1 161 ? -13.065 -13.747 -7.254  1.000 31.275 0 161 ILE A CD1   1 ? 
ATOM   1275 N  N     . SER A 1 162 ? -10.245 -11.848 -7.350  1.000 15.140 0 162 SER A N     1 ? 
ATOM   1276 C  CA    . SER A 1 162 ? -9.696  -10.669 -6.635  1.000 15.408 0 162 SER A CA    1 ? 
ATOM   1277 C  C     . SER A 1 162 ? -10.846 -9.872  -6.045  1.000 16.282 0 162 SER A C     1 ? 
ATOM   1278 O  O     . SER A 1 162 ? -11.921 -9.879  -6.615  1.000 17.055 0 162 SER A O     1 ? 
ATOM   1279 C  CB    . SER A 1 162 ? -8.876  -9.839  -7.534  1.000 20.055 0 162 SER A CB    1 ? 
ATOM   1280 O  OG    . SER A 1 162 ? -8.107  -8.906  -6.769  1.000 27.038 0 162 SER A OG    1 ? 
ATOM   1281 N  N     . ASP A 1 163 ? -10.626 -9.223  -4.898  1.000 12.833 0 163 ASP A N     1 ? 
ATOM   1282 C  CA    . ASP A 1 163 ? -11.707 -8.510  -4.200  1.000 12.157 0 163 ASP A CA    1 ? 
ATOM   1283 C  C     . ASP A 1 163 ? -11.170 -7.166  -3.717  1.000 11.199 0 163 ASP A C     1 ? 
ATOM   1284 O  O     . ASP A 1 163 ? -11.135 -6.911  -2.505  1.000 11.489 0 163 ASP A O     1 ? 
ATOM   1285 C  CB    . ASP A 1 163 ? -12.274 -9.344  -3.070  1.000 11.015 0 163 ASP A CB    1 ? 
ATOM   1286 C  CG    . ASP A 1 163 ? -13.514 -8.751  -2.433  1.000 11.628 0 163 ASP A CG    1 ? 
ATOM   1287 O  OD1   . ASP A 1 163 ? -14.076 -7.817  -3.039  1.000 13.237 0 163 ASP A OD1   1 ? 
ATOM   1288 O  OD2   . ASP A 1 163 ? -13.882 -9.248  -1.360  1.000 14.496 0 163 ASP A OD2   1 ? 
ATOM   1289 N  N     . PRO A 1 164 ? -10.787 -6.248  -4.619  1.000 11.057 0 164 PRO A N     1 ? 
ATOM   1290 C  CA    . PRO A 1 164 ? -10.255 -4.943  -4.207  1.000 11.687 0 164 PRO A CA    1 ? 
ATOM   1291 C  C     . PRO A 1 164 ? -11.293 -4.091  -3.456  1.000 12.370 0 164 PRO A C     1 ? 
ATOM   1292 O  O     . PRO A 1 164 ? -10.938 -3.445  -2.460  1.000 12.425 0 164 PRO A O     1 ? 
ATOM   1293 C  CB    . PRO A 1 164 ? -9.805  -4.290  -5.511  1.000 12.079 0 164 PRO A CB    1 ? 
ATOM   1294 C  CG    . PRO A 1 164 ? -10.620 -5.022  -6.603  1.000 11.853 0 164 PRO A CG    1 ? 
ATOM   1295 C  CD    . PRO A 1 164 ? -10.762 -6.426  -6.091  1.000 12.309 0 164 PRO A CD    1 ? 
ATOM   1296 N  N     . GLN A 1 165 ? -12.552 -4.181  -3.816  1.000 13.844 0 165 GLN A N     1 ? 
ATOM   1297 C  CA    . GLN A 1 165 ? -13.561 -3.340  -3.118  1.000 14.130 0 165 GLN A CA    1 ? 
ATOM   1298 C  C     . GLN A 1 165 ? -13.867 -3.945  -1.760  1.000 12.102 0 165 GLN A C     1 ? 
ATOM   1299 O  O     . GLN A 1 165 ? -14.047 -3.159  -0.814  1.000 10.560 0 165 GLN A O     1 ? 
ATOM   1300 C  CB    . GLN A 1 165 ? -14.760 -3.078  -4.027  1.000 19.254 0 165 GLN A CB    1 ? 
ATOM   1301 C  CG    . GLN A 1 165 ? -14.326 -2.269  -5.244  1.000 23.885 0 165 GLN A CG    1 ? 
ATOM   1302 C  CD    . GLN A 1 165 ? -15.418 -1.572  -5.997  1.000 29.462 0 165 GLN A CD    1 ? 
ATOM   1303 O  OE1   . GLN A 1 165 ? -15.419 -0.343  -6.134  1.000 32.305 0 165 GLN A OE1   1 ? 
ATOM   1304 N  NE2   . GLN A 1 165 ? -16.257 -2.368  -6.636  1.000 34.628 0 165 GLN A NE2   1 ? 
ATOM   1305 N  N     . GLY A 1 166 ? -13.816 -5.246  -1.593  1.000 11.927 0 166 GLY A N     1 ? 
ATOM   1306 C  CA    . GLY A 1 166 ? -13.945 -5.848  -0.282  1.000 10.282 0 166 GLY A CA    1 ? 
ATOM   1307 C  C     . GLY A 1 166 ? -12.766 -5.463  0.615   1.000 9.530  0 166 GLY A C     1 ? 
ATOM   1308 O  O     . GLY A 1 166 ? -12.956 -5.203  1.796   1.000 9.370  0 166 GLY A O     1 ? 
ATOM   1309 N  N     . PHE A 1 167 ? -11.545 -5.434  0.096   1.000 9.245  0 167 PHE A N     1 ? 
ATOM   1310 C  CA    . PHE A 1 167 ? -10.390 -5.010  0.904   1.000 8.963  0 167 PHE A CA    1 ? 
ATOM   1311 C  C     . PHE A 1 167 ? -10.592 -3.566  1.314   1.000 7.813  0 167 PHE A C     1 ? 
ATOM   1312 O  O     . PHE A 1 167 ? -10.399 -3.231  2.492   1.000 7.949  0 167 PHE A O     1 ? 
ATOM   1313 C  CB    . PHE A 1 167 ? -9.075  -5.200  0.155   1.000 9.357  0 167 PHE A CB    1 ? 
ATOM   1314 C  CG    . PHE A 1 167 ? -7.857  -4.940  1.029   1.000 9.778  0 167 PHE A CG    1 ? 
ATOM   1315 C  CD1   . PHE A 1 167 ? -7.647  -5.663  2.185   1.000 9.872  0 167 PHE A CD1   1 ? 
ATOM   1316 C  CD2   . PHE A 1 167 ? -7.000  -3.900  0.743   1.000 10.489 0 167 PHE A CD2   1 ? 
ATOM   1317 C  CE1   . PHE A 1 167 ? -6.550  -5.422  2.993   1.000 10.140 0 167 PHE A CE1   1 ? 
ATOM   1318 C  CE2   . PHE A 1 167 ? -5.924  -3.631  1.584   1.000 11.617 0 167 PHE A CE2   1 ? 
ATOM   1319 C  CZ    . PHE A 1 167 ? -5.681  -4.399  2.665   1.000 10.506 0 167 PHE A CZ    1 ? 
ATOM   1320 N  N     . GLN A 1 168 ? -10.951 -2.707  0.399   1.000 8.277  0 168 GLN A N     1 ? 
ATOM   1321 C  CA    . GLN A 1 168 ? -11.155 -1.280  0.713   1.000 9.154  0 168 GLN A CA    1 ? 
ATOM   1322 C  C     . GLN A 1 168 ? -12.239 -1.138  1.797   1.000 8.701  0 168 GLN A C     1 ? 
ATOM   1323 O  O     . GLN A 1 168 ? -12.049 -0.385  2.779   1.000 8.118  0 168 GLN A O     1 ? 
ATOM   1324 C  CB    . GLN A 1 168 ? -11.596 -0.519  -0.520  1.000 10.955 0 168 GLN A CB    1 ? 
ATOM   1325 C  CG    . GLN A 1 168 ? -10.485 -0.297  -1.516  1.000 16.303 0 168 GLN A CG    1 ? 
ATOM   1326 C  CD    . GLN A 1 168 ? -11.033 0.203   -2.825  1.000 18.746 0 168 GLN A CD    1 ? 
ATOM   1327 O  OE1   . GLN A 1 168 ? -10.637 -0.291  -3.931  1.000 23.476 0 168 GLN A OE1   1 ? 
ATOM   1328 N  NE2   . GLN A 1 168 ? -12.095 1.031   -2.716  1.000 19.698 0 168 GLN A NE2   1 ? 
ATOM   1329 N  N     . ASP A 1 169 ? -13.306 -1.916  1.707   1.000 8.454  0 169 ASP A N     1 ? 
ATOM   1330 C  CA    . ASP A 1 169 ? -14.373 -1.897  2.730   1.000 9.183  0 169 ASP A CA    1 ? 
ATOM   1331 C  C     . ASP A 1 169 ? -13.839 -2.384  4.087   1.000 9.038  0 169 ASP A C     1 ? 
ATOM   1332 O  O     . ASP A 1 169 ? -14.174 -1.791  5.121   1.000 9.545  0 169 ASP A O     1 ? 
ATOM   1333 C  CB    . ASP A 1 169 ? -15.532 -2.791  2.291   1.000 10.538 0 169 ASP A CB    1 ? 
ATOM   1334 C  CG    . ASP A 1 169 ? -16.669 -2.803  3.315   1.000 15.246 0 169 ASP A CG    1 ? 
ATOM   1335 O  OD1   . ASP A 1 169 ? -17.047 -3.964  3.780   1.000 18.740 0 169 ASP A OD1   1 ? 
ATOM   1336 O  OD2   . ASP A 1 169 ? -17.050 -1.704  3.773   1.000 11.741 0 169 ASP A OD2   1 ? 
ATOM   1337 N  N     . ARG A 1 170 ? -13.025 -3.420  4.101   1.000 8.464  0 170 ARG A N     1 ? 
ATOM   1338 C  CA    . ARG A 1 170 ? -12.489 -3.951  5.364   1.000 9.339  0 170 ARG A CA    1 ? 
ATOM   1339 C  C     . ARG A 1 170 ? -11.581 -2.888  6.054   1.000 7.814  0 170 ARG A C     1 ? 
ATOM   1340 O  O     . ARG A 1 170 ? -11.685 -2.680  7.286   1.000 8.326  0 170 ARG A O     1 ? 
ATOM   1341 C  CB    . ARG A 1 170 ? -11.708 -5.227  5.077   1.000 10.923 0 170 ARG A CB    1 ? 
ATOM   1342 C  CG    . ARG A 1 170 ? -12.557 -6.399  4.599   1.000 14.155 0 170 ARG A CG    1 ? 
ATOM   1343 C  CD    . ARG A 1 170 ? -12.875 -7.294  5.713   1.000 15.493 0 170 ARG A CD    1 ? 
ATOM   1344 N  NE    . ARG A 1 170 ? -13.964 -8.229  5.395   1.000 15.572 0 170 ARG A NE    1 ? 
ATOM   1345 C  CZ    . ARG A 1 170 ? -14.424 -9.118  6.241   1.000 16.496 0 170 ARG A CZ    1 ? 
ATOM   1346 N  NH1   . ARG A 1 170 ? -13.840 -9.301  7.405   1.000 15.511 0 170 ARG A NH1   1 ? 
ATOM   1347 N  NH2   . ARG A 1 170 ? -15.515 -9.812  5.922   1.000 14.734 0 170 ARG A NH2   1 ? 
ATOM   1348 N  N     . ILE A 1 171 ? -10.810 -2.138  5.285   1.000 7.233  0 171 ILE A N     1 ? 
ATOM   1349 C  CA    . ILE A 1 171 ? -9.969  -1.083  5.857   1.000 6.787  0 171 ILE A CA    1 ? 
ATOM   1350 C  C     . ILE A 1 171 ? -10.857 0.044   6.359   1.000 7.487  0 171 ILE A C     1 ? 
ATOM   1351 O  O     . ILE A 1 171 ? -10.595 0.570   7.466   1.000 7.384  0 171 ILE A O     1 ? 
ATOM   1352 C  CB    . ILE A 1 171 ? -8.876  -0.676  4.848   1.000 6.467  0 171 ILE A CB    1 ? 
ATOM   1353 C  CG1   . ILE A 1 171 ? -7.974  -1.878  4.499   1.000 7.491  0 171 ILE A CG1   1 ? 
ATOM   1354 C  CG2   . ILE A 1 171 ? -8.059  0.527   5.366   1.000 6.592  0 171 ILE A CG2   1 ? 
ATOM   1355 C  CD1   . ILE A 1 171 ? -7.368  -2.576  5.653   1.000 7.153  0 171 ILE A CD1   1 ? 
ATOM   1356 N  N     . ALA A 1 172 ? -11.843 0.444   5.587   1.000 7.833  0 172 ALA A N     1 ? 
ATOM   1357 C  CA    . ALA A 1 172 ? -12.739 1.574   5.965   1.000 8.431  0 172 ALA A CA    1 ? 
ATOM   1358 C  C     . ALA A 1 172 ? -13.556 1.223   7.207   1.000 8.488  0 172 ALA A C     1 ? 
ATOM   1359 O  O     . ALA A 1 172 ? -13.861 2.141   8.025   1.000 8.967  0 172 ALA A O     1 ? 
ATOM   1360 C  CB    . ALA A 1 172 ? -13.638 1.878   4.815   1.000 8.266  0 172 ALA A CB    1 ? 
ATOM   1361 N  N     . SER A 1 173 ? -13.904 -0.041  7.368   1.000 8.054  0 173 SER A N     1 ? 
ATOM   1362 C  CA    . SER A 1 173 ? -14.980 -0.441  8.294   1.000 8.924  0 173 SER A CA    1 ? 
ATOM   1363 C  C     . SER A 1 173 ? -14.417 -0.989  9.604   1.000 7.759  0 173 SER A C     1 ? 
ATOM   1364 O  O     . SER A 1 173 ? -15.214 -1.185  10.537  1.000 9.818  0 173 SER A O     1 ? 
ATOM   1365 C  CB    . SER A 1 173 ? -15.888 -1.474  7.684   1.000 8.998  0 173 SER A CB    1 ? 
ATOM   1366 O  OG    . SER A 1 173 ? -16.420 -1.007  6.442   1.000 10.825 0 173 SER A OG    1 ? 
ATOM   1367 N  N     . LYS A 1 174 ? -13.107 -1.248  9.723   1.000 7.687  0 174 LYS A N     1 ? 
ATOM   1368 C  CA    . LYS A 1 174 ? -12.565 -1.901  10.938  1.000 8.435  0 174 LYS A CA    1 ? 
ATOM   1369 C  C     . LYS A 1 174 ? -12.913 -1.059  12.179  1.000 7.968  0 174 LYS A C     1 ? 
ATOM   1370 O  O     . LYS A 1 174 ? -13.247 -1.631  13.218  1.000 10.798 0 174 LYS A O     1 ? 
ATOM   1371 C  CB    . LYS A 1 174 ? -11.058 -2.068  10.753  1.000 8.420  0 174 LYS A CB    1 ? 
ATOM   1372 C  CG    . LYS A 1 174 ? -10.349 -2.705  11.932  1.000 9.438  0 174 LYS A CG    1 ? 
ATOM   1373 C  CD    . LYS A 1 174 ? -8.879  -2.866  11.752  1.000 10.305 0 174 LYS A CD    1 ? 
ATOM   1374 C  CE    . LYS A 1 174 ? -8.159  -3.239  13.035  1.000 11.106 0 174 LYS A CE    1 ? 
ATOM   1375 N  NZ    . LYS A 1 174 ? -8.559  -4.573  13.545  1.000 11.809 0 174 LYS A NZ    1 ? 
ATOM   1376 N  N     . LEU A 1 175 ? -12.734 0.239   12.045  1.000 7.691  0 175 LEU A N     1 ? 
ATOM   1377 C  CA    . LEU A 1 175 ? -12.960 1.239   13.095  1.000 7.460  0 175 LEU A CA    1 ? 
ATOM   1378 C  C     . LEU A 1 175 ? -13.774 2.401   12.506  1.000 8.197  0 175 LEU A C     1 ? 
ATOM   1379 O  O     . LEU A 1 175 ? -13.975 2.442   11.298  1.000 8.247  0 175 LEU A O     1 ? 
ATOM   1380 C  CB    . LEU A 1 175 ? -11.589 1.732   13.622  1.000 8.706  0 175 LEU A CB    1 ? 
ATOM   1381 C  CG    . LEU A 1 175 ? -10.734 0.671   14.315  1.000 8.927  0 175 LEU A CG    1 ? 
ATOM   1382 C  CD1   . LEU A 1 175 ? -9.298  1.164   14.433  1.000 9.130  0 175 LEU A CD1   1 ? 
ATOM   1383 C  CD2   . LEU A 1 175 ? -11.284 0.365   15.695  1.000 9.970  0 175 LEU A CD2   1 ? 
ATOM   1384 N  N     . SER A 1 176 ? -14.187 3.331   13.355  1.000 8.214  0 176 SER A N     1 ? 
ATOM   1385 C  CA    . SER A 1 176 ? -14.882 4.544   12.904  1.000 7.704  0 176 SER A CA    1 ? 
ATOM   1386 C  C     . SER A 1 176 ? -14.282 5.791   13.556  1.000 7.802  0 176 SER A C     1 ? 
ATOM   1387 O  O     . SER A 1 176 ? -13.484 5.693   14.572  1.000 6.603  0 176 SER A O     1 ? 
ATOM   1388 C  CB    . SER A 1 176 ? -16.374 4.474   13.169  1.000 9.046  0 176 SER A CB    1 ? 
ATOM   1389 O  OG    . SER A 1 176 ? -16.574 4.506   14.567  1.000 10.282 0 176 SER A OG    1 ? 
ATOM   1390 N  N     . GLY A 1 177 ? -14.648 6.960   13.056  1.000 7.651  0 177 GLY A N     1 ? 
ATOM   1391 C  CA    . GLY A 1 177 ? -14.289 8.228   13.680  1.000 7.593  0 177 GLY A CA    1 ? 
ATOM   1392 C  C     . GLY A 1 177 ? -12.819 8.355   14.041  1.000 7.271  0 177 GLY A C     1 ? 
ATOM   1393 O  O     . GLY A 1 177 ? -11.958 8.089   13.174  1.000 7.968  0 177 GLY A O     1 ? 
ATOM   1394 N  N     . ASP A 1 178 ? -12.528 8.953   15.177  1.000 8.205  0 178 ASP A N     1 ? 
ATOM   1395 C  CA    . ASP A 1 178 ? -11.142 9.293   15.534  1.000 8.247  0 178 ASP A CA    1 ? 
ATOM   1396 C  C     . ASP A 1 178 ? -10.349 7.990   15.824  1.000 7.895  0 178 ASP A C     1 ? 
ATOM   1397 O  O     . ASP A 1 178 ? -9.147  8.032   15.702  1.000 7.324  0 178 ASP A O     1 ? 
ATOM   1398 C  CB    . ASP A 1 178 ? -11.151 10.223  16.724  1.000 8.754  0 178 ASP A CB    1 ? 
ATOM   1399 C  CG    . ASP A 1 178 ? -11.648 11.622  16.399  1.000 12.286 0 178 ASP A CG    1 ? 
ATOM   1400 O  OD1   . ASP A 1 178 ? -11.727 11.975  15.200  1.000 14.427 0 178 ASP A OD1   1 ? 
ATOM   1401 O  OD2   . ASP A 1 178 ? -11.950 12.350  17.366  1.000 15.528 0 178 ASP A OD2   1 ? 
ATOM   1402 N  N     . ASP A 1 179 ? -10.974 6.859   16.115  1.000 7.693  0 179 ASP A N     1 ? 
ATOM   1403 C  CA    . ASP A 1 179 ? -10.268 5.576   16.230  1.000 7.724  0 179 ASP A CA    1 ? 
ATOM   1404 C  C     . ASP A 1 179 ? -9.735  5.194   14.854  1.000 6.586  0 179 ASP A C     1 ? 
ATOM   1405 O  O     . ASP A 1 179 ? -8.522  4.827   14.740  1.000 6.246  0 179 ASP A O     1 ? 
ATOM   1406 C  CB    . ASP A 1 179 ? -11.172 4.454   16.727  1.000 7.731  0 179 ASP A CB    1 ? 
ATOM   1407 C  CG    . ASP A 1 179 ? -11.528 4.520   18.184  1.000 9.671  0 179 ASP A CG    1 ? 
ATOM   1408 O  OD1   . ASP A 1 179 ? -11.007 5.401   18.907  1.000 9.595  0 179 ASP A OD1   1 ? 
ATOM   1409 O  OD2   . ASP A 1 179 ? -12.387 3.693   18.566  1.000 13.383 0 179 ASP A OD2   1 ? 
ATOM   1410 N  N     . ALA A 1 180 ? -10.563 5.253   13.826  1.000 5.930  0 180 ALA A N     1 ? 
ATOM   1411 C  CA    . ALA A 1 180 ? -10.159 4.971   12.442  1.000 6.379  0 180 ALA A CA    1 ? 
ATOM   1412 C  C     . ALA A 1 180 ? -9.119  5.978   11.963  1.000 6.074  0 180 ALA A C     1 ? 
ATOM   1413 O  O     . ALA A 1 180 ? -8.156  5.585   11.266  1.000 5.398  0 180 ALA A O     1 ? 
ATOM   1414 C  CB    . ALA A 1 180 ? -11.339 4.995   11.543  1.000 6.301  0 180 ALA A CB    1 ? 
ATOM   1415 N  N     . ALA A 1 181 ? -9.201  7.242   12.404  1.000 6.457  0 181 ALA A N     1 ? 
ATOM   1416 C  CA    . ALA A 1 181 ? -8.187  8.238   12.079  1.000 6.162  0 181 ALA A CA    1 ? 
ATOM   1417 C  C     . ALA A 1 181 ? -6.836  7.801   12.637  1.000 6.255  0 181 ALA A C     1 ? 
ATOM   1418 O  O     . ALA A 1 181 ? -5.834  7.898   11.898  1.000 5.483  0 181 ALA A O     1 ? 
ATOM   1419 C  CB    . ALA A 1 181 ? -8.581  9.598   12.595  1.000 6.658  0 181 ALA A CB    1 ? 
ATOM   1420 N  N     . GLN A 1 182 ? -6.776  7.334   13.880  1.000 5.067  0 182 GLN A N     1 ? 
ATOM   1421 C  CA    . GLN A 1 182 ? -5.470  6.871   14.445  1.000 5.387  0 182 GLN A CA    1 ? 
ATOM   1422 C  C     . GLN A 1 182 ? -4.934  5.677   13.632  1.000 5.365  0 182 GLN A C     1 ? 
ATOM   1423 O  O     . GLN A 1 182 ? -3.708  5.597   13.379  1.000 5.340  0 182 GLN A O     1 ? 
ATOM   1424 C  CB    . GLN A 1 182 ? -5.569  6.518   15.926  1.000 5.577  0 182 GLN A CB    1 ? 
ATOM   1425 C  CG    . GLN A 1 182 ? -4.199  6.217   16.527  1.000 5.563  0 182 GLN A CG    1 ? 
ATOM   1426 C  CD    . GLN A 1 182 ? -4.291  5.828   17.976  1.000 5.763  0 182 GLN A CD    1 ? 
ATOM   1427 O  OE1   . GLN A 1 182 ? -5.010  4.891   18.358  1.000 6.411  0 182 GLN A OE1   1 ? 
ATOM   1428 N  NE2   . GLN A 1 182 ? -3.512  6.507   18.799  1.000 5.617  0 182 GLN A NE2   1 ? 
ATOM   1429 N  N     . PHE A 1 183 ? -5.760  4.744   13.287  1.000 5.426  0 183 PHE A N     1 ? 
ATOM   1430 C  CA    . PHE A 1 183 ? -5.417  3.572   12.467  1.000 5.422  0 183 PHE A CA    1 ? 
ATOM   1431 C  C     . PHE A 1 183 ? -4.758  4.049   11.163  1.000 5.474  0 183 PHE A C     1 ? 
ATOM   1432 O  O     . PHE A 1 183 ? -3.651  3.597   10.788  1.000 6.039  0 183 PHE A O     1 ? 
ATOM   1433 C  CB    . PHE A 1 183 ? -6.703  2.798   12.232  1.000 5.575  0 183 PHE A CB    1 ? 
ATOM   1434 C  CG    . PHE A 1 183 ? -6.727  1.713   11.196  1.000 6.105  0 183 PHE A CG    1 ? 
ATOM   1435 C  CD1   . PHE A 1 183 ? -6.016  0.546   11.357  1.000 6.121  0 183 PHE A CD1   1 ? 
ATOM   1436 C  CD2   . PHE A 1 183 ? -7.563  1.804   10.107  1.000 7.033  0 183 PHE A CD2   1 ? 
ATOM   1437 C  CE1   . PHE A 1 183 ? -6.147  -0.485  10.454  1.000 7.208  0 183 PHE A CE1   1 ? 
ATOM   1438 C  CE2   . PHE A 1 183 ? -7.654  0.783   9.188   1.000 7.568  0 183 PHE A CE2   1 ? 
ATOM   1439 C  CZ    . PHE A 1 183 ? -6.926  -0.355  9.361   1.000 7.311  0 183 PHE A CZ    1 ? 
ATOM   1440 N  N     . ARG A 1 184 ? -5.405  4.984   10.452  1.000 6.039  0 184 ARG A N     1 ? 
ATOM   1441 C  CA    . ARG A 1 184 ? -4.851  5.496   9.179   1.000 5.953  0 184 ARG A CA    1 ? 
ATOM   1442 C  C     . ARG A 1 184 ? -3.558  6.268   9.428   1.000 5.561  0 184 ARG A C     1 ? 
ATOM   1443 O  O     . ARG A 1 184 ? -2.618  6.128   8.621   1.000 5.565  0 184 ARG A O     1 ? 
ATOM   1444 C  CB    . ARG A 1 184 ? -5.868  6.348   8.488   1.000 6.430  0 184 ARG A CB    1 ? 
ATOM   1445 C  CG    . ARG A 1 184 ? -7.088  5.573   8.030   1.000 6.989  0 184 ARG A CG    1 ? 
ATOM   1446 C  CD    . ARG A 1 184 ? -7.981  6.396   7.080   1.000 7.809  0 184 ARG A CD    1 ? 
ATOM   1447 N  NE    . ARG A 1 184 ? -8.432  7.634   7.669   1.000 8.420  0 184 ARG A NE    1 ? 
ATOM   1448 C  CZ    . ARG A 1 184 ? -9.545  7.740   8.404   1.000 9.155  0 184 ARG A CZ    1 ? 
ATOM   1449 N  NH1   . ARG A 1 184 ? -10.302 6.682   8.592   1.000 10.221 0 184 ARG A NH1   1 ? 
ATOM   1450 N  NH2   . ARG A 1 184 ? -9.889  8.910   8.912   1.000 12.582 0 184 ARG A NH2   1 ? 
ATOM   1451 N  N     . ARG A 1 185 ? -3.465  7.051   10.512  1.000 5.537  0 185 ARG A N     1 ? 
ATOM   1452 C  CA    . ARG A 1 185 ? -2.194  7.751   10.812  1.000 5.832  0 185 ARG A CA    1 ? 
ATOM   1453 C  C     . ARG A 1 185 ? -1.084  6.734   10.989  1.000 5.255  0 185 ARG A C     1 ? 
ATOM   1454 O  O     . ARG A 1 185 ? 0.031   6.947   10.436  1.000 5.353  0 185 ARG A O     1 ? 
ATOM   1455 C  CB    . ARG A 1 185 ? -2.265  8.622   12.057  1.000 5.969  0 185 ARG A CB    1 ? 
ATOM   1456 C  CG    . ARG A 1 185 ? -3.191  9.812   11.953  1.000 5.961  0 185 ARG A CG    1 ? 
ATOM   1457 C  CD    . ARG A 1 185 ? -2.954  10.899  12.971  1.000 6.381  0 185 ARG A CD    1 ? 
ATOM   1458 N  NE    . ARG A 1 185 ? -3.198  10.408  14.331  1.000 6.698  0 185 ARG A NE    1 ? 
ATOM   1459 C  CZ    . ARG A 1 185 ? -4.399  10.380  14.929  1.000 6.030  0 185 ARG A CZ    1 ? 
ATOM   1460 N  NH1   . ARG A 1 185 ? -5.490  10.789  14.295  1.000 6.955  0 185 ARG A NH1   1 ? 
ATOM   1461 N  NH2   . ARG A 1 185 ? -4.492  9.958   16.187  1.000 6.351  0 185 ARG A NH2   1 ? 
ATOM   1462 N  N     . CYS A 1 186 ? -1.319  5.643   11.660  1.000 5.165  0 186 CYS A N     1 ? 
ATOM   1463 C  CA    . CYS A 1 186 ? -0.259  4.679   11.948  1.000 6.205  0 186 CYS A CA    1 ? 
ATOM   1464 C  C     . CYS A 1 186 ? 0.141   3.951   10.675  1.000 5.240  0 186 CYS A C     1 ? 
ATOM   1465 O  O     . CYS A 1 186 ? 1.356   3.652   10.531  1.000 5.691  0 186 CYS A O     1 ? 
ATOM   1466 C  CB    . CYS A 1 186 ? -0.657  3.738   13.046  1.000 6.504  0 186 CYS A CB    1 ? 
ATOM   1467 S  SG    . CYS A 1 186 ? -0.624  4.523   14.670  1.000 8.768  0 186 CYS A SG    1 ? 
ATOM   1468 N  N     . ILE A 1 187 ? -0.756  3.628   9.770   1.000 5.229  0 187 ILE A N     1 ? 
ATOM   1469 C  CA    . ILE A 1 187 ? -0.404  3.101   8.455   1.000 5.310  0 187 ILE A CA    1 ? 
ATOM   1470 C  C     . ILE A 1 187 ? 0.503   4.116   7.766   1.000 4.956  0 187 ILE A C     1 ? 
ATOM   1471 O  O     . ILE A 1 187 ? 1.591   3.712   7.223   1.000 5.863  0 187 ILE A O     1 ? 
ATOM   1472 C  CB    . ILE A 1 187 ? -1.674  2.751   7.644   1.000 5.179  0 187 ILE A CB    1 ? 
ATOM   1473 C  CG1   . ILE A 1 187 ? -2.425  1.553   8.244   1.000 5.663  0 187 ILE A CG1   1 ? 
ATOM   1474 C  CG2   . ILE A 1 187 ? -1.306  2.521   6.191   1.000 5.730  0 187 ILE A CG2   1 ? 
ATOM   1475 C  CD1   . ILE A 1 187 ? -3.835  1.455   7.799   1.000 5.754  0 187 ILE A CD1   1 ? 
ATOM   1476 N  N     . ARG A 1 188 ? 0.136   5.363   7.754   1.000 4.828  0 188 ARG A N     1 ? 
ATOM   1477 C  CA    . ARG A 1 188 ? 0.998   6.394   7.102   1.000 5.130  0 188 ARG A CA    1 ? 
ATOM   1478 C  C     . ARG A 1 188 ? 2.367   6.465   7.762   1.000 4.830  0 188 ARG A C     1 ? 
ATOM   1479 O  O     . ARG A 1 188 ? 3.375   6.579   7.085   1.000 5.095  0 188 ARG A O     1 ? 
ATOM   1480 C  CB    . ARG A 1 188 ? 0.319   7.754   7.108   1.000 5.511  0 188 ARG A CB    1 ? 
ATOM   1481 C  CG    . ARG A 1 188 ? -0.887  7.834   6.191   1.000 6.479  0 188 ARG A CG    1 ? 
ATOM   1482 C  CD    . ARG A 1 188 ? -1.378  9.243   6.172   1.000 7.966  0 188 ARG A CD    1 ? 
ATOM   1483 N  NE    . ARG A 1 188 ? -2.296  9.493   5.073   1.000 8.554  0 188 ARG A NE    1 ? 
ATOM   1484 C  CZ    . ARG A 1 188 ? -3.537  9.804   5.218   1.000 10.722 0 188 ARG A CZ    1 ? 
ATOM   1485 N  NH1   . ARG A 1 188 ? -4.075  9.827   6.430   1.000 12.717 0 188 ARG A NH1   1 ? 
ATOM   1486 N  NH2   . ARG A 1 188 ? -4.261  10.016  4.122   1.000 11.068 0 188 ARG A NH2   1 ? 
ATOM   1487 N  N     . TYR A 1 189 ? 2.443   6.463   9.084   1.000 4.728  0 189 TYR A N     1 ? 
ATOM   1488 C  CA    . TYR A 1 189 ? 3.773   6.535   9.756   1.000 5.226  0 189 TYR A CA    1 ? 
ATOM   1489 C  C     . TYR A 1 189 ? 4.657   5.416   9.248   1.000 5.575  0 189 TYR A C     1 ? 
ATOM   1490 O  O     . TYR A 1 189 ? 5.854   5.648   8.955   1.000 6.150  0 189 TYR A O     1 ? 
ATOM   1491 C  CB    . TYR A 1 189 ? 3.651   6.438   11.271  1.000 5.715  0 189 TYR A CB    1 ? 
ATOM   1492 C  CG    . TYR A 1 189 ? 2.810   7.503   11.917  1.000 5.733  0 189 TYR A CG    1 ? 
ATOM   1493 C  CD1   . TYR A 1 189 ? 2.843   8.833   11.512  1.000 5.844  0 189 TYR A CD1   1 ? 
ATOM   1494 C  CD2   . TYR A 1 189 ? 2.042   7.193   13.032  1.000 5.796  0 189 TYR A CD2   1 ? 
ATOM   1495 C  CE1   . TYR A 1 189 ? 2.054   9.785   12.110  1.000 6.687  0 189 TYR A CE1   1 ? 
ATOM   1496 C  CE2   . TYR A 1 189 ? 1.254   8.135   13.643  1.000 5.913  0 189 TYR A CE2   1 ? 
ATOM   1497 C  CZ    . TYR A 1 189 ? 1.288   9.452   13.215  1.000 6.749  0 189 TYR A CZ    1 ? 
ATOM   1498 O  OH    . TYR A 1 189 ? 0.492   10.408  13.842  1.000 7.350  0 189 TYR A OH    1 ? 
ATOM   1499 N  N     . LEU A 1 190 ? 4.127   4.204   9.120   1.000 5.689  0 190 LEU A N     1 ? 
ATOM   1500 C  CA    . LEU A 1 190 ? 4.963   3.063   8.729   1.000 6.276  0 190 LEU A CA    1 ? 
ATOM   1501 C  C     . LEU A 1 190 ? 5.342   3.205   7.266   1.000 5.532  0 190 LEU A C     1 ? 
ATOM   1502 O  O     . LEU A 1 190 ? 6.409   2.750   6.877   1.000 5.762  0 190 LEU A O     1 ? 
ATOM   1503 C  CB    . LEU A 1 190 ? 4.283   1.725   8.999   1.000 7.199  0 190 LEU A CB    1 ? 
ATOM   1504 C  CG    . LEU A 1 190 ? 4.223   1.363   10.477  1.000 9.368  0 190 LEU A CG    1 ? 
ATOM   1505 C  CD1   . LEU A 1 190 ? 3.687   -0.046  10.640  1.000 12.228 0 190 LEU A CD1   1 ? 
ATOM   1506 C  CD2   . LEU A 1 190 ? 5.546   1.504   11.201  1.000 10.570 0 190 LEU A CD2   1 ? 
ATOM   1507 N  N     . LYS A 1 191 ? 4.540   3.836   6.448   1.000 5.653  0 191 LYS A N     1 ? 
ATOM   1508 C  CA    . LYS A 1 191 ? 4.887   4.031   5.024   1.000 6.044  0 191 LYS A CA    1 ? 
ATOM   1509 C  C     . LYS A 1 191 ? 6.031   5.051   4.912   1.000 6.324  0 191 LYS A C     1 ? 
ATOM   1510 O  O     . LYS A 1 191 ? 6.911   4.856   4.049   1.000 6.090  0 191 LYS A O     1 ? 
ATOM   1511 C  CB    . LYS A 1 191 ? 3.691   4.500   4.226   1.000 6.508  0 191 LYS A CB    1 ? 
ATOM   1512 C  CG    . LYS A 1 191 ? 2.677   3.417   3.989   1.000 7.888  0 191 LYS A CG    1 ? 
ATOM   1513 C  CD    . LYS A 1 191 ? 1.523   3.913   3.180   1.000 9.093  0 191 LYS A CD    1 ? 
ATOM   1514 C  CE    . LYS A 1 191 ? 0.549   2.833   2.885   1.000 9.246  0 191 LYS A CE    1 ? 
ATOM   1515 N  NZ    . LYS A 1 191 ? -0.548  3.399   2.098   1.000 9.819  0 191 LYS A NZ    1 ? 
ATOM   1516 N  N     . ARG A 1 192 ? 6.061   6.094   5.737   1.000 6.004  0 192 ARG A N     1 ? 
ATOM   1517 C  CA    . ARG A 1 192 ? 7.194   7.037   5.685   1.000 5.938  0 192 ARG A CA    1 ? 
ATOM   1518 C  C     . ARG A 1 192 ? 8.451   6.366   6.232   1.000 6.682  0 192 ARG A C     1 ? 
ATOM   1519 O  O     . ARG A 1 192 ? 9.528   6.513   5.634   1.000 6.324  0 192 ARG A O     1 ? 
ATOM   1520 C  CB    . ARG A 1 192 ? 6.883   8.323   6.441   1.000 6.401  0 192 ARG A CB    1 ? 
ATOM   1521 C  CG    . ARG A 1 192 ? 8.074   9.276   6.495   1.000 6.532  0 192 ARG A CG    1 ? 
ATOM   1522 C  CD    . ARG A 1 192 ? 8.735   9.581   5.160   1.000 6.545  0 192 ARG A CD    1 ? 
ATOM   1523 N  NE    . ARG A 1 192 ? 7.885   10.262  4.208   1.000 6.736  0 192 ARG A NE    1 ? 
ATOM   1524 C  CZ    . ARG A 1 192 ? 7.658   11.587  4.208   1.000 7.058  0 192 ARG A CZ    1 ? 
ATOM   1525 N  NH1   . ARG A 1 192 ? 8.232   12.376  5.108   1.000 7.507  0 192 ARG A NH1   1 ? 
ATOM   1526 N  NH2   . ARG A 1 192 ? 6.815   12.081  3.335   1.000 7.362  0 192 ARG A NH2   1 ? 
ATOM   1527 N  N     . TRP A 1 193 ? 8.333   5.580   7.287   1.000 5.347  0 193 TRP A N     1 ? 
ATOM   1528 C  CA    . TRP A 1 193 ? 9.453   4.748   7.783   1.000 5.556  0 193 TRP A CA    1 ? 
ATOM   1529 C  C     . TRP A 1 193 ? 9.974   3.838   6.676   1.000 5.598  0 193 TRP A C     1 ? 
ATOM   1530 O  O     . TRP A 1 193 ? 11.198  3.768   6.456   1.000 5.831  0 193 TRP A O     1 ? 
ATOM   1531 C  CB    . TRP A 1 193 ? 8.982   3.912   8.964   1.000 5.296  0 193 TRP A CB    1 ? 
ATOM   1532 C  CG    . TRP A 1 193 ? 9.928   2.829   9.370   1.000 5.399  0 193 TRP A CG    1 ? 
ATOM   1533 C  CD1   . TRP A 1 193 ? 11.106  2.960   10.056  1.000 5.685  0 193 TRP A CD1   1 ? 
ATOM   1534 C  CD2   . TRP A 1 193 ? 9.712   1.415   9.202   1.000 6.318  0 193 TRP A CD2   1 ? 
ATOM   1535 N  NE1   . TRP A 1 193 ? 11.635  1.708   10.291  1.000 5.916  0 193 TRP A NE1   1 ? 
ATOM   1536 C  CE2   . TRP A 1 193 ? 10.794  0.757   9.790   1.000 5.775  0 193 TRP A CE2   1 ? 
ATOM   1537 C  CE3   . TRP A 1 193 ? 8.699   0.651   8.579   1.000 6.509  0 193 TRP A CE3   1 ? 
ATOM   1538 C  CZ2   . TRP A 1 193 ? 10.869  -0.642  9.808   1.000 6.267  0 193 TRP A CZ2   1 ? 
ATOM   1539 C  CZ3   . TRP A 1 193 ? 8.765   -0.716  8.629   1.000 6.679  0 193 TRP A CZ3   1 ? 
ATOM   1540 C  CH2   . TRP A 1 193 ? 9.863   -1.345  9.209   1.000 7.179  0 193 TRP A CH2   1 ? 
ATOM   1541 N  N     . ARG A 1 194 ? 9.098   3.195   5.948   1.000 6.073  0 194 ARG A N     1 ? 
ATOM   1542 C  CA    . ARG A 1 194 ? 9.458   2.337   4.806   1.000 7.320  0 194 ARG A CA    1 ? 
ATOM   1543 C  C     . ARG A 1 194 ? 10.232  3.150   3.782   1.000 7.011  0 194 ARG A C     1 ? 
ATOM   1544 O  O     . ARG A 1 194 ? 11.323  2.720   3.351   1.000 7.308  0 194 ARG A O     1 ? 
ATOM   1545 C  CB    . ARG A 1 194 ? 8.219   1.727   4.191   1.000 8.239  0 194 ARG A CB    1 ? 
ATOM   1546 C  CG    . ARG A 1 194 ? 8.471   1.030   2.865   1.000 10.102 0 194 ARG A CG    1 ? 
ATOM   1547 C  CD    . ARG A 1 194 ? 7.255   0.905   2.035   1.000 12.557 0 194 ARG A CD    1 ? 
ATOM   1548 N  NE    . ARG A 1 194 ? 6.711   2.188   1.635   1.000 14.145 0 194 ARG A NE    1 ? 
ATOM   1549 C  CZ    . ARG A 1 194 ? 5.481   2.342   1.135   1.000 16.718 0 194 ARG A CZ    1 ? 
ATOM   1550 N  NH1   . ARG A 1 194 ? 4.710   1.273   0.946   1.000 19.406 0 194 ARG A NH1   1 ? 
ATOM   1551 N  NH2   . ARG A 1 194 ? 5.060   3.544   0.816   1.000 20.678 0 194 ARG A NH2   1 ? 
ATOM   1552 N  N     . ASP A 1 195 ? 9.744   4.321   3.410   1.000 7.280  0 195 ASP A N     1 ? 
ATOM   1553 C  CA    . ASP A 1 195 ? 10.387  5.103   2.339   1.000 7.678  0 195 ASP A CA    1 ? 
ATOM   1554 C  C     . ASP A 1 195 ? 11.736  5.646   2.828   1.000 7.557  0 195 ASP A C     1 ? 
ATOM   1555 O  O     . ASP A 1 195 ? 12.666  5.726   2.025   1.000 10.134 0 195 ASP A O     1 ? 
ATOM   1556 C  CB    . ASP A 1 195 ? 9.487   6.234   1.897   1.000 7.964  0 195 ASP A CB    1 ? 
ATOM   1557 C  CG    . ASP A 1 195 ? 8.274   5.774   1.130   1.000 11.199 0 195 ASP A CG    1 ? 
ATOM   1558 O  OD1   . ASP A 1 195 ? 8.184   4.589   0.779   1.000 11.769 0 195 ASP A OD1   1 ? 
ATOM   1559 O  OD2   . ASP A 1 195 ? 7.430   6.616   0.839   1.000 13.029 0 195 ASP A OD2   1 ? 
ATOM   1560 N  N     . PHE A 1 196 ? 11.885  5.968   4.125   1.000 7.436  0 196 PHE A N     1 ? 
ATOM   1561 C  CA    . PHE A 1 196 ? 13.120  6.541   4.656   1.000 7.573  0 196 PHE A CA    1 ? 
ATOM   1562 C  C     . PHE A 1 196 ? 14.175  5.452   4.848   1.000 7.272  0 196 PHE A C     1 ? 
ATOM   1563 O  O     . PHE A 1 196 ? 15.384  5.680   4.586   1.000 9.633  0 196 PHE A O     1 ? 
ATOM   1564 C  CB    . PHE A 1 196 ? 12.867  7.264   5.957   1.000 7.631  0 196 PHE A CB    1 ? 
ATOM   1565 C  CG    . PHE A 1 196 ? 14.085  7.867   6.582   1.000 8.063  0 196 PHE A CG    1 ? 
ATOM   1566 C  CD1   . PHE A 1 196 ? 14.847  8.816   5.897   1.000 10.290 0 196 PHE A CD1   1 ? 
ATOM   1567 C  CD2   . PHE A 1 196 ? 14.490  7.501   7.843   1.000 8.186  0 196 PHE A CD2   1 ? 
ATOM   1568 C  CE1   . PHE A 1 196 ? 15.961  9.385   6.526   1.000 9.043  0 196 PHE A CE1   1 ? 
ATOM   1569 C  CE2   . PHE A 1 196 ? 15.609  8.048   8.438   1.000 8.353  0 196 PHE A CE2   1 ? 
ATOM   1570 C  CZ    . PHE A 1 196 ? 16.334  8.989   7.773   1.000 9.341  0 196 PHE A CZ    1 ? 
ATOM   1571 N  N     . ARG A 1 197 ? 13.796  4.264   5.297   1.000 6.537  0 197 ARG A N     1 ? 
ATOM   1572 C  CA    . ARG A 1 197 ? 14.779  3.255   5.721   1.000 8.325  0 197 ARG A CA    1 ? 
ATOM   1573 C  C     . ARG A 1 197 ? 14.887  2.099   4.729   1.000 8.149  0 197 ARG A C     1 ? 
ATOM   1574 O  O     . ARG A 1 197 ? 15.752  1.239   4.980   1.000 9.844  0 197 ARG A O     1 ? 
ATOM   1575 C  CB    . ARG A 1 197 ? 14.443  2.706   7.089   1.000 8.010  0 197 ARG A CB    1 ? 
ATOM   1576 C  CG    . ARG A 1 197 ? 14.511  3.739   8.188   1.000 8.795  0 197 ARG A CG    1 ? 
ATOM   1577 C  CD    . ARG A 1 197 ? 15.194  3.203   9.392   1.000 11.797 0 197 ARG A CD    1 ? 
ATOM   1578 N  NE    . ARG A 1 197 ? 16.666  3.164   9.226   1.000 9.844  0 197 ARG A NE    1 ? 
ATOM   1579 C  CZ    . ARG A 1 197 ? 17.462  2.476   10.044  1.000 13.632 0 197 ARG A CZ    1 ? 
ATOM   1580 N  NH1   . ARG A 1 197 ? 16.956  1.860   11.099  1.000 13.428 0 197 ARG A NH1   1 ? 
ATOM   1581 N  NH2   . ARG A 1 197 ? 18.782  2.537   9.889   1.000 11.958 0 197 ARG A NH2   1 ? 
ATOM   1582 N  N     . PHE A 1 198 ? 14.106  2.040   3.661   1.000 7.614  0 198 PHE A N     1 ? 
ATOM   1583 C  CA    . PHE A 1 198 ? 14.220  0.960   2.653   1.000 9.014  0 198 PHE A CA    1 ? 
ATOM   1584 C  C     . PHE A 1 198 ? 14.448  1.567   1.291   1.000 14.822 0 198 PHE A C     1 ? 
ATOM   1585 O  O     . PHE A 1 198 ? 14.068  0.941   0.342   1.000 23.001 0 198 PHE A O     1 ? 
ATOM   1586 C  CB    . PHE A 1 198 ? 12.992  0.049   2.689   1.000 7.844  0 198 PHE A CB    1 ? 
ATOM   1587 C  CG    . PHE A 1 198 ? 12.754  -0.656  4.003   1.000 7.463  0 198 PHE A CG    1 ? 
ATOM   1588 C  CD1   . PHE A 1 198 ? 12.252  0.016   5.105   1.000 7.282  0 198 PHE A CD1   1 ? 
ATOM   1589 C  CD2   . PHE A 1 198 ? 12.930  -2.042  4.129   1.000 8.042  0 198 PHE A CD2   1 ? 
ATOM   1590 C  CE1   . PHE A 1 198 ? 12.019  -0.636  6.312   1.000 7.367  0 198 PHE A CE1   1 ? 
ATOM   1591 C  CE2   . PHE A 1 198 ? 12.632  -2.689  5.309   1.000 8.498  0 198 PHE A CE2   1 ? 
ATOM   1592 C  CZ    . PHE A 1 198 ? 12.219  -2.003  6.412   1.000 8.030  0 198 PHE A CZ    1 ? 
ATOM   1593 N  N     . SER A 1 199 ? 15.253  2.637   1.239   1.000 23.657 0 199 SER A N     1 ? 
ATOM   1594 C  CA    . SER A 1 199 ? 15.613  3.413   0.008   1.000 27.762 0 199 SER A CA    1 ? 
ATOM   1595 C  C     . SER A 1 199 ? 16.858  2.836   -0.715  1.000 28.605 0 199 SER A C     1 ? 
ATOM   1596 O  O     . SER A 1 199 ? 16.989  3.106   -1.915  1.000 30.286 0 199 SER A O     1 ? 
ATOM   1597 C  CB    . SER A 1 199 ? 15.811  4.883   0.341   1.000 29.824 0 199 SER A CB    1 ? 
ATOM   1598 O  OG    . SER A 1 199 ? 16.988  5.088   1.100   1.000 38.645 0 199 SER A OG    1 ? 
ATOM   1599 N  N     . SER A 1 200 ? 17.735  2.091   -0.023  1.000 27.284 0 200 SER A N     1 ? 
ATOM   1600 C  CA    . SER A 1 200 ? 18.926  1.402   -0.632  1.000 26.231 0 200 SER A CA    1 ? 
ATOM   1601 C  C     . SER A 1 200 ? 18.463  0.347   -1.630  1.000 27.401 0 200 SER A C     1 ? 
ATOM   1602 O  O     . SER A 1 200 ? 19.139  0.165   -2.721  1.000 28.775 0 200 SER A O     1 ? 
ATOM   1603 C  CB    . SER A 1 200 ? 19.800  0.750   0.407   1.000 22.720 0 200 SER A CB    1 ? 
ATOM   1604 O  OG    . SER A 1 200 ? 20.393  1.710   1.225   1.000 25.945 0 200 SER A OG    1 ? 
ATOM   1605 N  N     . ASP A 1 201 ? 17.483  -0.439  -1.199  1.000 26.500 0 201 ASP A N     1 ? 
ATOM   1606 C  CA    . ASP A 1 201 ? 17.022  -1.655  -1.883  1.000 26.155 0 201 ASP A CA    1 ? 
ATOM   1607 C  C     . ASP A 1 201 ? 15.495  -1.589  -2.005  1.000 27.568 0 201 ASP A C     1 ? 
ATOM   1608 O  O     . ASP A 1 201 ? 14.824  -2.163  -1.150  1.000 27.404 0 201 ASP A O     1 ? 
ATOM   1609 C  CB    . ASP A 1 201 ? 17.479  -2.920  -1.124  1.000 24.462 0 201 ASP A CB    1 ? 
ATOM   1610 C  CG    . ASP A 1 201 ? 17.347  -4.149  -2.000  1.000 30.883 0 201 ASP A CG    1 ? 
ATOM   1611 O  OD1   . ASP A 1 201 ? 16.753  -3.992  -3.148  1.000 28.882 0 201 ASP A OD1   1 ? 
ATOM   1612 O  OD2   . ASP A 1 201 ? 17.798  -5.267  -1.545  1.000 39.618 0 201 ASP A OD2   1 ? 
ATOM   1613 N  N     . GLY A 1 202 ? 14.987  -0.922  -3.042  1.000 30.531 0 202 GLY A N     1 ? 
ATOM   1614 C  CA    . GLY A 1 202 ? 13.548  -0.883  -3.398  1.000 29.022 0 202 GLY A CA    1 ? 
ATOM   1615 C  C     . GLY A 1 202 ? 12.821  -2.217  -3.181  1.000 29.049 0 202 GLY A C     1 ? 
ATOM   1616 O  O     . GLY A 1 202 ? 11.744  -2.207  -2.540  1.000 21.060 0 202 GLY A O     1 ? 
ATOM   1617 N  N     . ASN A 1 203 ? 13.322  -3.336  -3.720  1.000 31.921 0 203 ASN A N     1 ? 
ATOM   1618 C  CA    . ASN A 1 203 ? 12.521  -4.609  -3.782  1.000 34.289 0 203 ASN A CA    1 ? 
ATOM   1619 C  C     . ASN A 1 203 ? 12.446  -5.282  -2.384  1.000 29.595 0 203 ASN A C     1 ? 
ATOM   1620 O  O     . ASN A 1 203 ? 11.641  -6.197  -2.194  1.000 32.987 0 203 ASN A O     1 ? 
ATOM   1621 C  CB    . ASN A 1 203 ? 13.059  -5.554  -4.850  1.000 40.819 0 203 ASN A CB    1 ? 
ATOM   1622 C  CG    . ASN A 1 203 ? 13.004  -4.950  -6.241  1.000 43.075 0 203 ASN A CG    1 ? 
ATOM   1623 O  OD1   . ASN A 1 203 ? 13.183  -3.741  -6.415  1.000 41.248 0 203 ASN A OD1   1 ? 
ATOM   1624 N  ND2   . ASN A 1 203 ? 12.718  -5.777  -7.235  1.000 56.196 0 203 ASN A ND2   1 ? 
ATOM   1625 N  N     . ALA A 1 204 ? 13.285  -4.844  -1.467  1.000 23.597 0 204 ALA A N     1 ? 
ATOM   1626 C  CA    . ALA A 1 204 ? 13.301  -5.221  -0.040  1.000 19.028 0 204 ALA A CA    1 ? 
ATOM   1627 C  C     . ALA A 1 204 ? 12.205  -4.513  0.760   1.000 16.390 0 204 ALA A C     1 ? 
ATOM   1628 O  O     . ALA A 1 204 ? 12.076  -4.786  1.935   1.000 14.994 0 204 ALA A O     1 ? 
ATOM   1629 C  CB    . ALA A 1 204 ? 14.655  -4.867  0.498   1.000 19.432 0 204 ALA A CB    1 ? 
ATOM   1630 N  N     . ALA A 1 205 ? 11.598  -3.455  0.229   1.000 13.064 0 205 ALA A N     1 ? 
ATOM   1631 C  CA    . ALA A 1 205 ? 10.692  -2.610  1.034   1.000 11.396 0 205 ALA A CA    1 ? 
ATOM   1632 C  C     . ALA A 1 205 ? 9.366   -3.344  1.200   1.000 12.780 0 205 ALA A C     1 ? 
ATOM   1633 O  O     . ALA A 1 205 ? 8.812   -3.884  0.247   1.000 14.509 0 205 ALA A O     1 ? 
ATOM   1634 C  CB    . ALA A 1 205 ? 10.487  -1.297  0.364   1.000 12.197 0 205 ALA A CB    1 ? 
ATOM   1635 N  N     . PRO A 1 206 ? 8.812   -3.333  2.407   1.000 12.373 0 206 PRO A N     1 ? 
ATOM   1636 C  CA    . PRO A 1 206 ? 7.478   -3.872  2.640   1.000 13.683 0 206 PRO A CA    1 ? 
ATOM   1637 C  C     . PRO A 1 206 ? 6.414   -3.128  1.809   1.000 14.015 0 206 PRO A C     1 ? 
ATOM   1638 O  O     . PRO A 1 206 ? 6.383   -1.912  1.831   1.000 15.825 0 206 PRO A O     1 ? 
ATOM   1639 C  CB    . PRO A 1 206 ? 7.258   -3.689  4.128   1.000 14.591 0 206 PRO A CB    1 ? 
ATOM   1640 C  CG    . PRO A 1 206 ? 8.306   -2.744  4.601   1.000 16.357 0 206 PRO A CG    1 ? 
ATOM   1641 C  CD    . PRO A 1 206 ? 9.444   -2.833  3.632   1.000 13.029 0 206 PRO A CD    1 ? 
ATOM   1642 N  N     . LEU A 1 207 ? 5.627   -3.831  1.054   1.000 12.020 0 207 LEU A N     1 ? 
ATOM   1643 C  CA    . LEU A 1 207 ? 4.594   -3.228  0.207   1.000 12.587 0 207 LEU A CA    1 ? 
ATOM   1644 C  C     . LEU A 1 207 ? 3.617   -2.467  1.102   1.000 12.370 0 207 LEU A C     1 ? 
ATOM   1645 O  O     . LEU A 1 207 ? 3.295   -2.967  2.154   1.000 12.804 0 207 LEU A O     1 ? 
ATOM   1646 C  CB    . LEU A 1 207 ? 3.847   -4.304  -0.591  1.000 14.912 0 207 LEU A CB    1 ? 
ATOM   1647 C  CG    . LEU A 1 207 ? 4.670   -5.038  -1.647  1.000 18.766 0 207 LEU A CG    1 ? 
ATOM   1648 C  CD1   . LEU A 1 207 ? 3.900   -6.237  -2.176  1.000 22.020 0 207 LEU A CD1   1 ? 
ATOM   1649 C  CD2   . LEU A 1 207 ? 5.076   -4.082  -2.784  1.000 23.975 0 207 LEU A CD2   1 ? 
ATOM   1650 N  N     . GLY A 1 208 ? 3.080   -1.363  0.605   1.000 12.885 0 208 GLY A N     1 ? 
ATOM   1651 C  CA    . GLY A 1 208 ? 2.025   -0.626  1.287   1.000 12.651 0 208 GLY A CA    1 ? 
ATOM   1652 C  C     . GLY A 1 208 ? 0.852   -1.525  1.626   1.000 11.981 0 208 GLY A C     1 ? 
ATOM   1653 O  O     . GLY A 1 208 ? 0.297   -1.382  2.713   1.000 11.926 0 208 GLY A O     1 ? 
ATOM   1654 N  N     . ILE A 1 209 ? 0.413   -2.376  0.715   1.000 12.245 0 209 ILE A N     1 ? 
ATOM   1655 C  CA    . ILE A 1 209 ? -0.734  -3.279  0.987   1.000 12.633 0 209 ILE A CA    1 ? 
ATOM   1656 C  C     . ILE A 1 209 ? -0.387  -4.192  2.167   1.000 11.438 0 209 ILE A C     1 ? 
ATOM   1657 O  O     . ILE A 1 209 ? -1.292  -4.558  2.934   1.000 11.929 0 209 ILE A O     1 ? 
ATOM   1658 C  CB    . ILE A 1 209 ? -1.201  -4.061  -0.270  1.000 16.217 0 209 ILE A CB    1 ? 
ATOM   1659 C  CG1   . ILE A 1 209 ? -2.537  -4.749  0.003   1.000 17.244 0 209 ILE A CG1   1 ? 
ATOM   1660 C  CG2   . ILE A 1 209 ? -0.134  -5.037  -0.767  1.000 17.253 0 209 ILE A CG2   1 ? 
ATOM   1661 C  CD1   . ILE A 1 209 ? -3.201  -5.320  -1.247  1.000 18.846 0 209 ILE A CD1   1 ? 
ATOM   1662 N  N     . GLY A 1 210 ? 0.854   -4.604  2.293   1.000 9.957  0 210 GLY A N     1 ? 
ATOM   1663 C  CA    . GLY A 1 210 ? 1.254   -5.503  3.399   1.000 9.138  0 210 GLY A CA    1 ? 
ATOM   1664 C  C     . GLY A 1 210 ? 1.211   -4.783  4.734   1.000 8.967  0 210 GLY A C     1 ? 
ATOM   1665 O  O     . GLY A 1 210 ? 0.716   -5.321  5.712   1.000 9.462  0 210 GLY A O     1 ? 
ATOM   1666 N  N     . LEU A 1 211 ? 1.682   -3.547  4.772   1.000 8.555  0 211 LEU A N     1 ? 
ATOM   1667 C  CA    . LEU A 1 211 ? 1.623   -2.761  6.015   1.000 7.783  0 211 LEU A CA    1 ? 
ATOM   1668 C  C     . LEU A 1 211 ? 0.154   -2.516  6.404   1.000 6.729  0 211 LEU A C     1 ? 
ATOM   1669 O  O     . LEU A 1 211 ? -0.173  -2.483  7.565   1.000 7.446  0 211 LEU A O     1 ? 
ATOM   1670 C  CB    . LEU A 1 211 ? 2.366   -1.441  5.784   1.000 8.622  0 211 LEU A CB    1 ? 
ATOM   1671 C  CG    . LEU A 1 211 ? 3.872   -1.573  5.583   1.000 10.397 0 211 LEU A CG    1 ? 
ATOM   1672 C  CD1   . LEU A 1 211 ? 4.450   -0.224  5.198   1.000 11.189 0 211 LEU A CD1   1 ? 
ATOM   1673 C  CD2   . LEU A 1 211 ? 4.504   -2.084  6.818   1.000 10.207 0 211 LEU A CD2   1 ? 
ATOM   1674 N  N     . THR A 1 212 ? -0.676  -2.265  5.406   1.000 7.218  0 212 THR A N     1 ? 
ATOM   1675 C  CA    . THR A 1 212 ? -2.104  -1.986  5.592   1.000 6.438  0 212 THR A CA    1 ? 
ATOM   1676 C  C     . THR A 1 212 ? -2.817  -3.256  6.102   1.000 7.220  0 212 THR A C     1 ? 
ATOM   1677 O  O     . THR A 1 212 ? -3.598  -3.154  7.049   1.000 6.866  0 212 THR A O     1 ? 
ATOM   1678 C  CB    . THR A 1 212 ? -2.702  -1.491  4.254   1.000 6.772  0 212 THR A CB    1 ? 
ATOM   1679 O  OG1   . THR A 1 212 ? -1.959  -0.318  3.873   1.000 8.390  0 212 THR A OG1   1 ? 
ATOM   1680 C  CG2   . THR A 1 212 ? -4.169  -1.160  4.355   1.000 6.997  0 212 THR A CG2   1 ? 
ATOM   1681 N  N     . ALA A 1 213 ? -2.570  -4.374  5.459   1.000 7.319  0 213 ALA A N     1 ? 
ATOM   1682 C  CA    . ALA A 1 213 ? -3.157  -5.665  5.882   1.000 7.350  0 213 ALA A CA    1 ? 
ATOM   1683 C  C     . ALA A 1 213 ? -2.651  -6.009  7.291   1.000 6.910  0 213 ALA A C     1 ? 
ATOM   1684 O  O     . ALA A 1 213 ? -3.436  -6.445  8.152   1.000 7.270  0 213 ALA A O     1 ? 
ATOM   1685 C  CB    . ALA A 1 213 ? -2.870  -6.744  4.884   1.000 8.019  0 213 ALA A CB    1 ? 
ATOM   1686 N  N     . ALA A 1 214 ? -1.392  -5.718  7.601   1.000 6.664  0 214 ALA A N     1 ? 
ATOM   1687 C  CA    . ALA A 1 214 ? -0.860  -5.965  8.958   1.000 7.126  0 214 ALA A CA    1 ? 
ATOM   1688 C  C     . ALA A 1 214 ? -1.621  -5.144  9.976   1.000 7.954  0 214 ALA A C     1 ? 
ATOM   1689 O  O     . ALA A 1 214 ? -1.992  -5.614  11.006  1.000 8.115  0 214 ALA A O     1 ? 
ATOM   1690 C  CB    . ALA A 1 214 ? 0.622   -5.681  8.975   1.000 7.680  0 214 ALA A CB    1 ? 
ATOM   1691 N  N     . ALA A 1 215 ? -1.890  -3.873  9.667   1.000 6.959  0 215 ALA A N     1 ? 
ATOM   1692 C  CA    . ALA A 1 215 ? -2.692  -3.026  10.536  1.000 6.701  0 215 ALA A CA    1 ? 
ATOM   1693 C  C     . ALA A 1 215 ? -4.114  -3.548  10.654  1.000 6.475  0 215 ALA A C     1 ? 
ATOM   1694 O  O     . ALA A 1 215 ? -4.651  -3.576  11.730  1.000 7.097  0 215 ALA A O     1 ? 
ATOM   1695 C  CB    . ALA A 1 215 ? -2.660  -1.603  10.018  1.000 6.912  0 215 ALA A CB    1 ? 
ATOM   1696 N  N     . TYR A 1 216 ? -4.688  -4.024  9.574   1.000 6.127  0 216 TYR A N     1 ? 
ATOM   1697 C  CA    . TYR A 1 216 ? -6.044  -4.625  9.651   1.000 7.175  0 216 TYR A CA    1 ? 
ATOM   1698 C  C     . TYR A 1 216 ? -6.070  -5.779  10.678  1.000 7.846  0 216 TYR A C     1 ? 
ATOM   1699 O  O     . TYR A 1 216 ? -7.022  -5.860  11.496  1.000 8.258  0 216 TYR A O     1 ? 
ATOM   1700 C  CB    . TYR A 1 216 ? -6.492  -5.150  8.300   1.000 7.913  0 216 TYR A CB    1 ? 
ATOM   1701 C  CG    . TYR A 1 216 ? -7.759  -5.969  8.364   1.000 8.578  0 216 TYR A CG    1 ? 
ATOM   1702 C  CD1   . TYR A 1 216 ? -9.015  -5.390  8.336   1.000 9.333  0 216 TYR A CD1   1 ? 
ATOM   1703 C  CD2   . TYR A 1 216 ? -7.664  -7.343  8.506   1.000 9.490  0 216 TYR A CD2   1 ? 
ATOM   1704 C  CE1   . TYR A 1 216 ? -10.148 -6.181  8.361   1.000 9.802  0 216 TYR A CE1   1 ? 
ATOM   1705 C  CE2   . TYR A 1 216 ? -8.791  -8.133  8.589   1.000 9.718  0 216 TYR A CE2   1 ? 
ATOM   1706 C  CZ    . TYR A 1 216 ? -10.026 -7.540  8.513   1.000 10.995 0 216 TYR A CZ    1 ? 
ATOM   1707 O  OH    . TYR A 1 216 ? -11.151 -8.340  8.620   1.000 13.227 0 216 TYR A OH    1 ? 
ATOM   1708 N  N     . TRP A 1 217 ? -5.065  -6.638  10.677  1.000 8.197  0 217 TRP A N     1 ? 
ATOM   1709 C  CA    . TRP A 1 217 ? -5.048  -7.788  11.630  1.000 9.034  0 217 TRP A CA    1 ? 
ATOM   1710 C  C     . TRP A 1 217 ? -4.717  -7.317  13.050  1.000 9.355  0 217 TRP A C     1 ? 
ATOM   1711 O  O     . TRP A 1 217 ? -5.330  -7.824  14.014  1.000 11.308 0 217 TRP A O     1 ? 
ATOM   1712 C  CB    . TRP A 1 217 ? -4.112  -8.861  11.189  1.000 9.335  0 217 TRP A CB    1 ? 
ATOM   1713 C  CG    . TRP A 1 217 ? -4.506  -9.532  9.924   1.000 9.277  0 217 TRP A CG    1 ? 
ATOM   1714 C  CD1   . TRP A 1 217 ? -3.843  -9.494  8.752   1.000 9.343  0 217 TRP A CD1   1 ? 
ATOM   1715 C  CD2   . TRP A 1 217 ? -5.638  -10.400 9.703   1.000 9.746  0 217 TRP A CD2   1 ? 
ATOM   1716 N  NE1   . TRP A 1 217 ? -4.484  -10.251 7.809   1.000 11.068 0 217 TRP A NE1   1 ? 
ATOM   1717 C  CE2   . TRP A 1 217 ? -5.606  -10.776 8.360   1.000 11.364 0 217 TRP A CE2   1 ? 
ATOM   1718 C  CE3   . TRP A 1 217 ? -6.706  -10.815 10.497  1.000 12.537 0 217 TRP A CE3   1 ? 
ATOM   1719 C  CZ2   . TRP A 1 217 ? -6.534  -11.659 7.815   1.000 13.447 0 217 TRP A CZ2   1 ? 
ATOM   1720 C  CZ3   . TRP A 1 217 ? -7.654  -11.652 9.952   1.000 13.823 0 217 TRP A CZ3   1 ? 
ATOM   1721 C  CH2   . TRP A 1 217 ? -7.586  -12.026 8.613   1.000 13.548 0 217 TRP A CH2   1 ? 
ATOM   1722 N  N     . TRP A 1 218 ? -3.779  -6.389  13.216  1.000 7.956  0 218 TRP A N     1 ? 
ATOM   1723 C  CA    . TRP A 1 218 ? -3.069  -6.253  14.495  1.000 8.988  0 218 TRP A CA    1 ? 
ATOM   1724 C  C     . TRP A 1 218 ? -3.145  -4.881  15.115  1.000 9.368  0 218 TRP A C     1 ? 
ATOM   1725 O  O     . TRP A 1 218 ? -2.772  -4.786  16.271  1.000 11.005 0 218 TRP A O     1 ? 
ATOM   1726 C  CB    . TRP A 1 218 ? -1.611  -6.685  14.320  1.000 8.621  0 218 TRP A CB    1 ? 
ATOM   1727 C  CG    . TRP A 1 218 ? -1.460  -8.120  13.957  1.000 9.800  0 218 TRP A CG    1 ? 
ATOM   1728 C  CD1   . TRP A 1 218 ? -2.131  -9.176  14.502  1.000 11.171 0 218 TRP A CD1   1 ? 
ATOM   1729 C  CD2   . TRP A 1 218 ? -0.655  -8.656  12.899  1.000 9.659  0 218 TRP A CD2   1 ? 
ATOM   1730 N  NE1   . TRP A 1 218 ? -1.796  -10.326 13.857  1.000 11.253 0 218 TRP A NE1   1 ? 
ATOM   1731 C  CE2   . TRP A 1 218 ? -0.823  -10.066 12.932  1.000 10.628 0 218 TRP A CE2   1 ? 
ATOM   1732 C  CE3   . TRP A 1 218 ? 0.283   -8.112  12.024  1.000 10.803 0 218 TRP A CE3   1 ? 
ATOM   1733 C  CZ2   . TRP A 1 218 ? -0.187  -10.902 12.000  1.000 11.673 0 218 TRP A CZ2   1 ? 
ATOM   1734 C  CZ3   . TRP A 1 218 ? 0.925   -8.929  11.132  1.000 12.443 0 218 TRP A CZ3   1 ? 
ATOM   1735 C  CH2   . TRP A 1 218 ? 0.693   -10.309 11.120  1.000 10.887 0 218 TRP A CH2   1 ? 
ATOM   1736 N  N     . PHE A 1 219 ? -3.565  -3.820  14.418  1.000 8.271  0 219 PHE A N     1 ? 
ATOM   1737 C  CA    . PHE A 1 219 ? -3.613  -2.509  15.043  1.000 8.336  0 219 PHE A CA    1 ? 
ATOM   1738 C  C     . PHE A 1 219 ? -4.634  -2.483  16.178  1.000 8.098  0 219 PHE A C     1 ? 
ATOM   1739 O  O     . PHE A 1 219 ? -5.734  -3.065  16.046  1.000 10.298 0 219 PHE A O     1 ? 
ATOM   1740 C  CB    . PHE A 1 219 ? -3.978  -1.449  14.013  1.000 7.474  0 219 PHE A CB    1 ? 
ATOM   1741 C  CG    . PHE A 1 219 ? -4.147  -0.092  14.617  1.000 7.124  0 219 PHE A CG    1 ? 
ATOM   1742 C  CD1   . PHE A 1 219 ? -3.050  0.740   14.860  1.000 7.545  0 219 PHE A CD1   1 ? 
ATOM   1743 C  CD2   . PHE A 1 219 ? -5.408  0.371   14.975  1.000 7.808  0 219 PHE A CD2   1 ? 
ATOM   1744 C  CE1   . PHE A 1 219 ? -3.251  1.946   15.499  1.000 7.616  0 219 PHE A CE1   1 ? 
ATOM   1745 C  CE2   . PHE A 1 219 ? -5.570  1.593   15.610  1.000 8.333  0 219 PHE A CE2   1 ? 
ATOM   1746 C  CZ    . PHE A 1 219 ? -4.500  2.346   15.876  1.000 7.660  0 219 PHE A CZ    1 ? 
ATOM   1747 N  N     . GLN A 1 220 ? -4.295  -1.787  17.248  1.000 7.648  0 220 GLN A N     1 ? 
ATOM   1748 C  CA    . GLN A 1 220 ? -5.207  -1.486  18.383  1.000 9.821  0 220 GLN A CA    1 ? 
ATOM   1749 C  C     . GLN A 1 220 ? -5.114  -0.006  18.704  1.000 8.149  0 220 GLN A C     1 ? 
ATOM   1750 O  O     . GLN A 1 220 ? -4.041  0.537   18.845  1.000 8.861  0 220 GLN A O     1 ? 
ATOM   1751 C  CB    . GLN A 1 220 ? -4.862  -2.320  19.605  1.000 12.269 0 220 GLN A CB    1 ? 
ATOM   1752 C  CG    . GLN A 1 220 ? -4.909  -3.812  19.370  1.000 14.426 0 220 GLN A CG    1 ? 
ATOM   1753 C  CD    . GLN A 1 220 ? -6.309  -4.350  19.242  1.000 19.615 0 220 GLN A CD    1 ? 
ATOM   1754 O  OE1   . GLN A 1 220 ? -7.289  -3.702  19.584  1.000 23.812 0 220 GLN A OE1   1 ? 
ATOM   1755 N  NE2   . GLN A 1 220 ? -6.406  -5.517  18.662  1.000 22.792 0 220 GLN A NE2   1 ? 
ATOM   1756 N  N     . VAL A 1 221 ? -6.235  0.637   18.907  1.000 8.139  0 221 VAL A N     1 ? 
ATOM   1757 C  CA    . VAL A 1 221 ? -6.304  2.029   19.345  1.000 8.735  0 221 VAL A CA    1 ? 
ATOM   1758 C  C     . VAL A 1 221 ? -5.561  2.196   20.645  1.000 8.271  0 221 VAL A C     1 ? 
ATOM   1759 O  O     . VAL A 1 221 ? -5.674  1.305   21.549  1.000 10.224 0 221 VAL A O     1 ? 
ATOM   1760 C  CB    . VAL A 1 221 ? -7.774  2.478   19.459  1.000 9.593  0 221 VAL A CB    1 ? 
ATOM   1761 C  CG1   . VAL A 1 221 ? -7.942  3.781   20.197  1.000 12.057 0 221 VAL A CG1   1 ? 
ATOM   1762 C  CG2   . VAL A 1 221 ? -8.423  2.537   18.078  1.000 10.842 0 221 VAL A CG2   1 ? 
ATOM   1763 N  N     . SER A 1 222 ? -4.966  3.334   20.825  1.000 8.366  0 222 SER A N     1 ? 
ATOM   1764 C  CA    . SER A 1 222 ? -4.466  3.774   22.162  1.000 8.623  0 222 SER A CA    1 ? 
ATOM   1765 C  C     . SER A 1 222 ? -4.986  5.165   22.414  1.000 9.004  0 222 SER A C     1 ? 
ATOM   1766 O  O     . SER A 1 222 ? -4.556  6.097   21.736  1.000 9.569  0 222 SER A O     1 ? 
ATOM   1767 C  CB    . SER A 1 222 ? -2.979  3.697   22.245  1.000 9.008  0 222 SER A CB    1 ? 
ATOM   1768 O  OG    . SER A 1 222 ? -2.538  4.128   23.532  1.000 10.440 0 222 SER A OG    1 ? 
ATOM   1769 N  N     . LYS A 1 223 ? -5.831  5.302   23.447  1.000 10.087 0 223 LYS A N     1 ? 
ATOM   1770 C  CA    . LYS A 1 223 ? -6.413  6.601   23.814  1.000 12.690 0 223 LYS A CA    1 ? 
ATOM   1771 C  C     . LYS A 1 223 ? -6.742  6.584   25.304  1.000 14.788 0 223 LYS A C     1 ? 
ATOM   1772 O  O     . LYS A 1 223 ? -6.800  5.495   25.885  1.000 17.343 0 223 LYS A O     1 ? 
ATOM   1773 C  CB    . LYS A 1 223 ? -7.683  6.894   23.000  1.000 11.897 0 223 LYS A CB    1 ? 
ATOM   1774 C  CG    . LYS A 1 223 ? -8.806  5.901   23.188  1.000 12.504 0 223 LYS A CG    1 ? 
ATOM   1775 C  CD    . LYS A 1 223 ? -10.020 6.168   22.355  1.000 13.306 0 223 LYS A CD    1 ? 
ATOM   1776 C  CE    . LYS A 1 223 ? -11.062 5.083   22.446  1.000 15.378 0 223 LYS A CE    1 ? 
ATOM   1777 N  NZ    . LYS A 1 223 ? -12.218 5.342   21.537  1.000 15.709 0 223 LYS A NZ    1 ? 
ATOM   1778 N  N     . ARG A 1 224 ? -6.951  7.753   25.867  1.000 17.676 0 224 ARG A N     1 ? 
ATOM   1779 C  CA    . ARG A 1 224 ? -7.374  7.904   27.281  1.000 21.383 0 224 ARG A CA    1 ? 
ATOM   1780 C  C     . ARG A 1 224 ? -8.522  8.879   27.361  1.000 21.489 0 224 ARG A C     1 ? 
ATOM   1781 O  O     . ARG A 1 224 ? -8.461  9.894   26.642  1.000 19.459 0 224 ARG A O     1 ? 
ATOM   1782 C  CB    . ARG A 1 224 ? -6.212  8.425   28.092  1.000 24.618 0 224 ARG A CB    1 ? 
ATOM   1783 C  CG    . ARG A 1 224 ? -5.084  7.421   28.232  1.000 26.810 0 224 ARG A CG    1 ? 
ATOM   1784 C  CD    . ARG A 1 224 ? -4.031  7.900   29.198  1.000 32.319 0 224 ARG A CD    1 ? 
ATOM   1785 N  NE    . ARG A 1 224 ? -4.561  8.104   30.542  1.000 38.565 0 224 ARG A NE    1 ? 
ATOM   1786 C  CZ    . ARG A 1 224 ? -3.830  8.502   31.586  1.000 45.400 0 224 ARG A CZ    1 ? 
ATOM   1787 N  NH1   . ARG A 1 224 ? -2.537  8.728   31.443  1.000 46.407 0 224 ARG A NH1   1 ? 
ATOM   1788 N  NH2   . ARG A 1 224 ? -4.396  8.671   32.766  1.000 46.024 0 224 ARG A NH2   1 ? 
ATOM   1789 N  N     . THR A 1 225 ? -9.466  8.629   28.302  1.000 26.840 0 225 THR A N     1 ? 
ATOM   1790 C  CA    . THR A 1 225 ? -10.628 9.515   28.592  1.000 27.730 0 225 THR A CA    1 ? 
ATOM   1791 C  C     . THR A 1 225 ? -10.410 10.167  29.945  1.000 26.241 0 225 THR A C     1 ? 
ATOM   1792 O  O     . THR A 1 225 ? -10.212 9.431   30.925  1.000 28.143 0 225 THR A O     1 ? 
ATOM   1793 C  CB    . THR A 1 225 ? -11.946 8.748   28.503  1.000 33.700 0 225 THR A CB    1 ? 
ATOM   1794 O  OG1   . THR A 1 225 ? -12.019 8.259   27.167  1.000 39.033 0 225 THR A OG1   1 ? 
ATOM   1795 C  CG2   . THR A 1 225 ? -13.163 9.596   28.808  1.000 37.120 0 225 THR A CG2   1 ? 
ATOM   1796 N  N     . ASP A 1 226 ? -10.320 11.487  29.959  1.000 26.469 0 226 ASP A N     1 ? 
ATOM   1797 C  CA    . ASP A 1 226 ? -10.052 12.296  31.173  1.000 26.234 0 226 ASP A CA    1 ? 
ATOM   1798 C  C     . ASP A 1 226 ? -11.193 12.101  32.147  1.000 27.765 0 226 ASP A C     1 ? 
ATOM   1799 O  O     . ASP A 1 226 ? -12.357 12.312  31.792  1.000 27.063 0 226 ASP A O     1 ? 
ATOM   1800 C  CB    . ASP A 1 226 ? -9.913  13.778  30.851  1.000 28.453 0 226 ASP A CB    1 ? 
ATOM   1801 C  CG    . ASP A 1 226 ? -9.477  14.578  32.050  1.000 36.181 0 226 ASP A CG    1 ? 
ATOM   1802 O  OD1   . ASP A 1 226 ? -10.348 15.190  32.685  1.000 39.645 0 226 ASP A OD1   1 ? 
ATOM   1803 O  OD2   . ASP A 1 226 ? -8.278  14.520  32.377  1.000 38.296 0 226 ASP A OD2   1 ? 
ATOM   1804 N  N     . PRO A 1 227 ? -10.904 11.764  33.418  1.000 27.126 0 227 PRO A N     1 ? 
ATOM   1805 C  CA    . PRO A 1 227 ? -11.967 11.416  34.363  1.000 29.181 0 227 PRO A CA    1 ? 
ATOM   1806 C  C     . PRO A 1 227 ? -12.838 12.609  34.813  1.000 31.315 0 227 PRO A C     1 ? 
ATOM   1807 O  O     . PRO A 1 227 ? -13.883 12.356  35.395  1.000 35.774 0 227 PRO A O     1 ? 
ATOM   1808 C  CB    . PRO A 1 227 ? -11.205 10.805  35.550  1.000 28.945 0 227 PRO A CB    1 ? 
ATOM   1809 C  CG    . PRO A 1 227 ? -9.826  11.450  35.484  1.000 28.056 0 227 PRO A CG    1 ? 
ATOM   1810 C  CD    . PRO A 1 227 ? -9.555  11.633  33.999  1.000 26.644 0 227 PRO A CD    1 ? 
ATOM   1811 N  N     . VAL A 1 228 ? -12.415 13.851  34.530  1.000 30.239 0 228 VAL A N     1 ? 
ATOM   1812 C  CA    . VAL A 1 228 ? -13.146 15.100  34.904  1.000 33.478 0 228 VAL A CA    1 ? 
ATOM   1813 C  C     . VAL A 1 228 ? -13.937 15.610  33.685  1.000 34.000 0 228 VAL A C     1 ? 
ATOM   1814 O  O     . VAL A 1 228 ? -15.159 15.831  33.836  1.000 36.395 0 228 VAL A O     1 ? 
ATOM   1815 C  CB    . VAL A 1 228 ? -12.186 16.172  35.464  1.000 36.972 0 228 VAL A CB    1 ? 
ATOM   1816 C  CG1   . VAL A 1 228 ? -12.902 17.472  35.786  1.000 38.272 0 228 VAL A CG1   1 ? 
ATOM   1817 C  CG2   . VAL A 1 228 ? -11.436 15.662  36.688  1.000 37.678 0 228 VAL A CG2   1 ? 
ATOM   1818 N  N     . SER A 1 229 ? -13.264 15.808  32.537  1.000 33.447 0 229 SER A N     1 ? 
ATOM   1819 C  CA    . SER A 1 229 ? -13.805 16.463  31.309  1.000 30.958 0 229 SER A CA    1 ? 
ATOM   1820 C  C     . SER A 1 229 ? -14.422 15.425  30.371  1.000 31.750 0 229 SER A C     1 ? 
ATOM   1821 O  O     . SER A 1 229 ? -15.205 15.824  29.496  1.000 34.861 0 229 SER A O     1 ? 
ATOM   1822 C  CB    . SER A 1 229 ? -12.734 17.216  30.599  1.000 31.290 0 229 SER A CB    1 ? 
ATOM   1823 O  OG    . SER A 1 229 ? -11.718 16.317  30.188  1.000 31.381 0 229 SER A OG    1 ? 
ATOM   1824 N  N     . GLN A 1 230 ? -14.065 14.154  30.549  1.000 31.094 0 230 GLN A N     1 ? 
ATOM   1825 C  CA    . GLN A 1 230 ? -14.278 13.056  29.572  1.000 39.026 0 230 GLN A CA    1 ? 
ATOM   1826 C  C     . GLN A 1 230 ? -13.657 13.428  28.203  1.000 31.226 0 230 GLN A C     1 ? 
ATOM   1827 O  O     . GLN A 1 230 ? -14.049 12.785  27.203  1.000 39.193 0 230 GLN A O     1 ? 
ATOM   1828 C  CB    . GLN A 1 230 ? -15.778 12.742  29.458  1.000 43.910 0 230 GLN A CB    1 ? 
ATOM   1829 C  CG    . GLN A 1 230 ? -16.192 11.452  30.165  1.000 49.807 0 230 GLN A CG    1 ? 
ATOM   1830 C  CD    . GLN A 1 230 ? -17.210 10.657  29.373  1.000 60.097 0 230 GLN A CD    1 ? 
ATOM   1831 O  OE1   . GLN A 1 230 ? -17.907 11.182  28.498  1.000 63.287 0 230 GLN A OE1   1 ? 
ATOM   1832 N  NE2   . GLN A 1 230 ? -17.310 9.372   29.680  1.000 61.495 0 230 GLN A NE2   1 ? 
ATOM   1833 N  N     . ASN A 1 231 ? -12.734 14.406  28.151  1.000 28.851 0 231 ASN A N     1 ? 
ATOM   1834 C  CA    . ASN A 1 231 ? -11.967 14.759  26.915  1.000 27.639 0 231 ASN A CA    1 ? 
ATOM   1835 C  C     . ASN A 1 231 ? -11.050 13.581  26.541  1.000 22.785 0 231 ASN A C     1 ? 
ATOM   1836 O  O     . ASN A 1 231 ? -10.476 12.926  27.453  1.000 23.875 0 231 ASN A O     1 ? 
ATOM   1837 C  CB    . ASN A 1 231 ? -11.169 16.060  27.040  1.000 31.153 0 231 ASN A CB    1 ? 
ATOM   1838 C  CG    . ASN A 1 231 ? -12.041 17.301  26.914  1.000 35.160 0 231 ASN A CG    1 ? 
ATOM   1839 O  OD1   . ASN A 1 231 ? -13.254 17.200  26.739  1.000 41.497 0 231 ASN A OD1   1 ? 
ATOM   1840 N  ND2   . ASN A 1 231 ? -11.427 18.469  26.970  1.000 37.389 0 231 ASN A ND2   1 ? 
ATOM   1841 N  N     . VAL A 1 232 ? -11.021 13.242  25.251  1.000 19.487 0 232 VAL A N     1 ? 
ATOM   1842 C  CA    . VAL A 1 232 ? -10.271 12.065  24.765  1.000 18.081 0 232 VAL A CA    1 ? 
ATOM   1843 C  C     . VAL A 1 232 ? -8.999  12.566  24.115  1.000 15.173 0 232 VAL A C     1 ? 
ATOM   1844 O  O     . VAL A 1 232 ? -9.052  13.506  23.285  1.000 17.649 0 232 VAL A O     1 ? 
ATOM   1845 C  CB    . VAL A 1 232 ? -11.099 11.219  23.798  1.000 19.731 0 232 VAL A CB    1 ? 
ATOM   1846 C  CG1   . VAL A 1 232 ? -10.288 10.048  23.294  1.000 18.806 0 232 VAL A CG1   1 ? 
ATOM   1847 C  CG2   . VAL A 1 232 ? -12.399 10.745  24.425  1.000 23.758 0 232 VAL A CG2   1 ? 
ATOM   1848 N  N     . THR A 1 233 ? -7.918  11.928  24.455  1.000 14.106 0 233 THR A N     1 ? 
ATOM   1849 C  CA    . THR A 1 233 ? -6.581  12.163  23.871  1.000 15.634 0 233 THR A CA    1 ? 
ATOM   1850 C  C     . THR A 1 233 ? -6.101  10.830  23.286  1.000 12.790 0 233 THR A C     1 ? 
ATOM   1851 O  O     . THR A 1 233 ? -6.282  9.782   23.912  1.000 14.481 0 233 THR A O     1 ? 
ATOM   1852 C  CB    . THR A 1 233 ? -5.586  12.755  24.895  1.000 18.574 0 233 THR A CB    1 ? 
ATOM   1853 O  OG1   . THR A 1 233 ? -5.598  11.900  26.043  1.000 22.686 0 233 THR A OG1   1 ? 
ATOM   1854 C  CG2   . THR A 1 233 ? -5.926  14.183  25.264  1.000 22.420 0 233 THR A CG2   1 ? 
ATOM   1855 N  N     . TYR A 1 234 ? -5.428  10.893  22.174  1.000 10.994 0 234 TYR A N     1 ? 
ATOM   1856 C  CA    . TYR A 1 234 ? -4.844  9.689   21.546  1.000 8.858  0 234 TYR A CA    1 ? 
ATOM   1857 C  C     . TYR A 1 234 ? -3.351  9.630   21.831  1.000 7.947  0 234 TYR A C     1 ? 
ATOM   1858 O  O     . TYR A 1 234 ? -2.694  10.671  22.026  1.000 8.933  0 234 TYR A O     1 ? 
ATOM   1859 C  CB    . TYR A 1 234 ? -5.190  9.635   20.048  1.000 8.953  0 234 TYR A CB    1 ? 
ATOM   1860 C  CG    . TYR A 1 234 ? -6.606  9.215   19.782  1.000 9.194  0 234 TYR A CG    1 ? 
ATOM   1861 C  CD1   . TYR A 1 234 ? -7.649  10.121  19.875  1.000 8.696  0 234 TYR A CD1   1 ? 
ATOM   1862 C  CD2   . TYR A 1 234 ? -6.916  7.910   19.446  1.000 8.592  0 234 TYR A CD2   1 ? 
ATOM   1863 C  CE1   . TYR A 1 234 ? -8.951  9.709   19.691  1.000 10.149 0 234 TYR A CE1   1 ? 
ATOM   1864 C  CE2   . TYR A 1 234 ? -8.216  7.496   19.173  1.000 9.659  0 234 TYR A CE2   1 ? 
ATOM   1865 C  CZ    . TYR A 1 234 ? -9.232  8.415   19.317  1.000 10.109 0 234 TYR A CZ    1 ? 
ATOM   1866 O  OH    . TYR A 1 234 ? -10.534 8.043   19.085  1.000 11.367 0 234 TYR A OH    1 ? 
ATOM   1867 N  N     . ASP A 1 235 ? -2.851  8.419   21.842  1.000 7.918  0 235 ASP A N     1 ? 
ATOM   1868 C  CA    . ASP A 1 235 ? -1.409  8.139   22.068  1.000 8.305  0 235 ASP A CA    1 ? 
ATOM   1869 C  C     . ASP A 1 235 ? -0.862  7.352   20.898  1.000 7.806  0 235 ASP A C     1 ? 
ATOM   1870 O  O     . ASP A 1 235 ? -0.827  6.150   20.930  1.000 7.670  0 235 ASP A O     1 ? 
ATOM   1871 C  CB    . ASP A 1 235 ? -1.222  7.414   23.397  1.000 9.611  0 235 ASP A CB    1 ? 
ATOM   1872 C  CG    . ASP A 1 235 ? 0.197   7.301   23.849  1.000 12.055 0 235 ASP A CG    1 ? 
ATOM   1873 O  OD1   . ASP A 1 235 ? 1.102   7.548   23.050  1.000 10.659 0 235 ASP A OD1   1 ? 
ATOM   1874 O  OD2   . ASP A 1 235 ? 0.367   7.081   25.096  1.000 12.467 0 235 ASP A OD2   1 ? 
ATOM   1875 N  N     . ASP A 1 236 ? -0.452  8.057   19.878  1.000 7.456  0 236 ASP A N     1 ? 
ATOM   1876 C  CA    . ASP A 1 236 ? 0.031   7.422   18.643  1.000 6.643  0 236 ASP A CA    1 ? 
ATOM   1877 C  C     . ASP A 1 236 ? 1.348   6.695   18.904  1.000 6.994  0 236 ASP A C     1 ? 
ATOM   1878 O  O     . ASP A 1 236 ? 1.546   5.611   18.360  1.000 6.572  0 236 ASP A O     1 ? 
ATOM   1879 C  CB    . ASP A 1 236 ? 0.200   8.423   17.530  1.000 6.275  0 236 ASP A CB    1 ? 
ATOM   1880 C  CG    . ASP A 1 236 ? -1.084  9.028   16.968  1.000 7.305  0 236 ASP A CG    1 ? 
ATOM   1881 O  OD1   . ASP A 1 236 ? -2.136  8.855   17.577  1.000 6.736  0 236 ASP A OD1   1 ? 
ATOM   1882 O  OD2   . ASP A 1 236 ? -0.956  9.664   15.942  1.000 7.575  0 236 ASP A OD2   1 ? 
ATOM   1883 N  N     . ARG A 1 237 ? 2.223   7.245   19.769  1.000 6.994  0 237 ARG A N     1 ? 
ATOM   1884 C  CA    . ARG A 1 237 ? 3.489   6.549   20.061  1.000 7.303  0 237 ARG A CA    1 ? 
ATOM   1885 C  C     . ARG A 1 237 ? 3.184   5.167   20.651  1.000 8.273  0 237 ARG A C     1 ? 
ATOM   1886 O  O     . ARG A 1 237 ? 3.765   4.180   20.244  1.000 7.883  0 237 ARG A O     1 ? 
ATOM   1887 C  CB    . ARG A 1 237 ? 4.353   7.368   21.005  1.000 7.570  0 237 ARG A CB    1 ? 
ATOM   1888 C  CG    . ARG A 1 237 ? 5.733   6.763   21.232  1.000 8.153  0 237 ARG A CG    1 ? 
ATOM   1889 C  CD    . ARG A 1 237 ? 6.300   7.130   22.635  1.000 9.131  0 237 ARG A CD    1 ? 
ATOM   1890 N  NE    . ARG A 1 237 ? 5.436   6.594   23.669  1.000 9.617  0 237 ARG A NE    1 ? 
ATOM   1891 C  CZ    . ARG A 1 237 ? 5.294   5.305   23.933  1.000 10.059 0 237 ARG A CZ    1 ? 
ATOM   1892 N  NH1   . ARG A 1 237 ? 6.121   4.426   23.413  1.000 10.285 0 237 ARG A NH1   1 ? 
ATOM   1893 N  NH2   . ARG A 1 237 ? 4.342   4.880   24.763  1.000 12.008 0 237 ARG A NH2   1 ? 
ATOM   1894 N  N     . ASP A 1 238 ? 2.285   5.101   21.624  1.000 7.772  0 238 ASP A N     1 ? 
ATOM   1895 C  CA    . ASP A 1 238 ? 1.885   3.817   22.255  1.000 8.694  0 238 ASP A CA    1 ? 
ATOM   1896 C  C     . ASP A 1 238 ? 1.213   2.917   21.214  1.000 8.229  0 238 ASP A C     1 ? 
ATOM   1897 O  O     . ASP A 1 238 ? 1.446   1.721   21.188  1.000 7.969  0 238 ASP A O     1 ? 
ATOM   1898 C  CB    . ASP A 1 238 ? 1.013   4.072   23.480  1.000 9.399  0 238 ASP A CB    1 ? 
ATOM   1899 C  CG    . ASP A 1 238 ? 0.613   2.786   24.158  1.000 11.197 0 238 ASP A CG    1 ? 
ATOM   1900 O  OD1   . ASP A 1 238 ? 1.531   2.055   24.606  1.000 12.881 0 238 ASP A OD1   1 ? 
ATOM   1901 O  OD2   . ASP A 1 238 ? -0.616  2.509   24.267  1.000 12.578 0 238 ASP A OD2   1 ? 
ATOM   1902 N  N     . ALA A 1 239 ? 0.280   3.453   20.415  1.000 8.185  0 239 ALA A N     1 ? 
ATOM   1903 C  CA    . ALA A 1 239 ? -0.436  2.613   19.425  1.000 8.930  0 239 ALA A CA    1 ? 
ATOM   1904 C  C     . ALA A 1 239 ? 0.601   2.007   18.485  1.000 7.572  0 239 ALA A C     1 ? 
ATOM   1905 O  O     . ALA A 1 239 ? 0.534   0.816   18.173  1.000 7.656  0 239 ALA A O     1 ? 
ATOM   1906 C  CB    . ALA A 1 239 ? -1.476  3.405   18.660  1.000 8.175  0 239 ALA A CB    1 ? 
ATOM   1907 N  N     . LEU A 1 240 ? 1.572   2.778   18.079  1.000 8.188  0 240 LEU A N     1 ? 
ATOM   1908 C  CA    . LEU A 1 240 ? 2.597   2.249   17.158  1.000 8.530  0 240 LEU A CA    1 ? 
ATOM   1909 C  C     . LEU A 1 240 ? 3.473   1.222   17.868  1.000 8.144  0 240 LEU A C     1 ? 
ATOM   1910 O  O     . LEU A 1 240 ? 3.785   0.211   17.288  1.000 8.287  0 240 LEU A O     1 ? 
ATOM   1911 C  CB    . LEU A 1 240 ? 3.473   3.382   16.612  1.000 10.485 0 240 LEU A CB    1 ? 
ATOM   1912 C  CG    . LEU A 1 240 ? 4.056   3.140   15.213  1.000 14.997 0 240 LEU A CG    1 ? 
ATOM   1913 C  CD1   . LEU A 1 240 ? 2.975   2.843   14.192  1.000 14.838 0 240 LEU A CD1   1 ? 
ATOM   1914 C  CD2   . LEU A 1 240 ? 4.837   4.340   14.751  1.000 15.262 0 240 LEU A CD2   1 ? 
ATOM   1915 N  N     . GLU A 1 241 ? 3.851   1.491   19.099  1.000 8.129  0 241 GLU A N     1 ? 
ATOM   1916 C  CA    . GLU A 1 241 ? 4.658   0.524   19.861  1.000 8.869  0 241 GLU A CA    1 ? 
ATOM   1917 C  C     . GLU A 1 241 ? 3.932   -0.820  19.890  1.000 8.890  0 241 GLU A C     1 ? 
ATOM   1918 O  O     . GLU A 1 241 ? 4.552   -1.864  19.638  1.000 8.913  0 241 GLU A O     1 ? 
ATOM   1919 C  CB    . GLU A 1 241 ? 4.933   1.065   21.257  1.000 10.023 0 241 GLU A CB    1 ? 
ATOM   1920 C  CG    . GLU A 1 241 ? 5.811   0.135   22.090  1.000 11.633 0 241 GLU A CG    1 ? 
ATOM   1921 C  CD    . GLU A 1 241 ? 5.891   0.505   23.558  1.000 13.728 0 241 GLU A CD    1 ? 
ATOM   1922 O  OE1   . GLU A 1 241 ? 5.998   -0.446  24.382  1.000 17.815 0 241 GLU A OE1   1 ? 
ATOM   1923 O  OE2   . GLU A 1 241 ? 5.869   1.646   23.877  1.000 15.298 0 241 GLU A OE2   1 ? 
ATOM   1924 N  N     . GLN A 1 242 ? 2.661   -0.819  20.283  1.000 8.576  0 242 GLN A N     1 ? 
ATOM   1925 C  CA    . GLN A 1 242 ? 1.933   -2.099  20.434  1.000 9.426  0 242 GLN A CA    1 ? 
ATOM   1926 C  C     . GLN A 1 242 ? 1.825   -2.804  19.081  1.000 8.480  0 242 GLN A C     1 ? 
ATOM   1927 O  O     . GLN A 1 242 ? 1.937   -4.055  19.014  1.000 8.852  0 242 GLN A O     1 ? 
ATOM   1928 C  CB    . GLN A 1 242 ? 0.543   -1.896  21.005  1.000 11.064 0 242 GLN A CB    1 ? 
ATOM   1929 C  CG    . GLN A 1 242 ? 0.541   -1.172  22.335  1.000 12.378 0 242 GLN A CG    1 ? 
ATOM   1930 C  CD    . GLN A 1 242 ? 1.484   -1.765  23.363  1.000 19.590 0 242 GLN A CD    1 ? 
ATOM   1931 O  OE1   . GLN A 1 242 ? 1.648   -2.975  23.452  1.000 23.586 0 242 GLN A OE1   1 ? 
ATOM   1932 N  NE2   . GLN A 1 242 ? 2.136   -0.907  24.135  1.000 23.794 0 242 GLN A NE2   1 ? 
ATOM   1933 N  N     . PHE A 1 243 ? 1.533   -2.058  18.014  1.000 7.977  0 243 PHE A N     1 ? 
ATOM   1934 C  CA    . PHE A 1 243 ? 1.361   -2.619  16.667  1.000 7.797  0 243 PHE A CA    1 ? 
ATOM   1935 C  C     . PHE A 1 243 ? 2.686   -3.203  16.163  1.000 6.768  0 243 PHE A C     1 ? 
ATOM   1936 O  O     . PHE A 1 243 ? 2.725   -4.302  15.697  1.000 7.642  0 243 PHE A O     1 ? 
ATOM   1937 C  CB    . PHE A 1 243 ? 0.799   -1.511  15.767  1.000 7.187  0 243 PHE A CB    1 ? 
ATOM   1938 C  CG    . PHE A 1 243 ? 0.664   -1.821  14.298  1.000 7.004  0 243 PHE A CG    1 ? 
ATOM   1939 C  CD1   . PHE A 1 243 ? 0.352   -3.076  13.823  1.000 6.794  0 243 PHE A CD1   1 ? 
ATOM   1940 C  CD2   . PHE A 1 243 ? 0.811   -0.788  13.367  1.000 7.393  0 243 PHE A CD2   1 ? 
ATOM   1941 C  CE1   . PHE A 1 243 ? 0.313   -3.339  12.462  1.000 7.479  0 243 PHE A CE1   1 ? 
ATOM   1942 C  CE2   . PHE A 1 243 ? 0.679   -1.031  12.005  1.000 8.009  0 243 PHE A CE2   1 ? 
ATOM   1943 C  CZ    . PHE A 1 243 ? 0.478   -2.305  11.555  1.000 7.727  0 243 PHE A CZ    1 ? 
ATOM   1944 N  N     . VAL A 1 244 ? 3.753   -2.447  16.279  1.000 7.003  0 244 VAL A N     1 ? 
ATOM   1945 C  CA    . VAL A 1 244 ? 5.095   -2.902  15.874  1.000 6.894  0 244 VAL A CA    1 ? 
ATOM   1946 C  C     . VAL A 1 244 ? 5.472   -4.149  16.693  1.000 7.404  0 244 VAL A C     1 ? 
ATOM   1947 O  O     . VAL A 1 244 ? 5.941   -5.135  16.092  1.000 7.722  0 244 VAL A O     1 ? 
ATOM   1948 C  CB    . VAL A 1 244 ? 6.129   -1.784  15.978  1.000 7.471  0 244 VAL A CB    1 ? 
ATOM   1949 C  CG1   . VAL A 1 244 ? 7.537   -2.291  15.772  1.000 7.782  0 244 VAL A CG1   1 ? 
ATOM   1950 C  CG2   . VAL A 1 244 ? 5.798   -0.725  14.930  1.000 8.922  0 244 VAL A CG2   1 ? 
ATOM   1951 N  N     . GLN A 1 245 ? 5.245   -4.124  17.998  1.000 7.982  0 245 GLN A N     1 ? 
ATOM   1952 C  CA    . GLN A 1 245 ? 5.584   -5.319  18.807  1.000 8.408  0 245 GLN A CA    1 ? 
ATOM   1953 C  C     . GLN A 1 245 ? 4.751   -6.520  18.341  1.000 8.955  0 245 GLN A C     1 ? 
ATOM   1954 O  O     . GLN A 1 245 ? 5.303   -7.672  18.185  1.000 9.126  0 245 GLN A O     1 ? 
ATOM   1955 C  CB    . GLN A 1 245 ? 5.413   -5.080  20.298  1.000 10.021 0 245 GLN A CB    1 ? 
ATOM   1956 C  CG    . GLN A 1 245 ? 5.841   -6.331  21.100  1.000 11.197 0 245 GLN A CG    1 ? 
ATOM   1957 C  CD    . GLN A 1 245 ? 7.295   -6.698  20.934  1.000 13.005 0 245 GLN A CD    1 ? 
ATOM   1958 O  OE1   . GLN A 1 245 ? 7.683   -7.670  20.254  1.000 15.937 0 245 GLN A OE1   1 ? 
ATOM   1959 N  NE2   . GLN A 1 245 ? 8.127   -5.837  21.438  1.000 19.040 0 245 GLN A NE2   1 ? 
ATOM   1960 N  N     . THR A 1 246 ? 3.474   -6.326  18.044  1.000 8.092  0 246 THR A N     1 ? 
ATOM   1961 C  CA    . THR A 1 246 ? 2.620   -7.423  17.599  1.000 8.843  0 246 THR A CA    1 ? 
ATOM   1962 C  C     . THR A 1 246 ? 3.147   -7.957  16.259  1.000 9.717  0 246 THR A C     1 ? 
ATOM   1963 O  O     . THR A 1 246 ? 3.202   -9.180  16.054  1.000 8.771  0 246 THR A O     1 ? 
ATOM   1964 C  CB    . THR A 1 246 ? 1.146   -7.014  17.583  1.000 8.985  0 246 THR A CB    1 ? 
ATOM   1965 O  OG1   . THR A 1 246 ? 0.767   -6.610  18.912  1.000 12.721 0 246 THR A OG1   1 ? 
ATOM   1966 C  CG2   . THR A 1 246 ? 0.256   -8.130  17.062  1.000 9.917  0 246 THR A CG2   1 ? 
ATOM   1967 N  N     . MET A 1 247 ? 3.509   -7.092  15.323  1.000 7.860  0 247 MET A N     1 ? 
ATOM   1968 C  CA    . MET A 1 247 ? 4.109   -7.556  14.057  1.000 8.208  0 247 MET A CA    1 ? 
ATOM   1969 C  C     . MET A 1 247 ? 5.356   -8.405  14.365  1.000 8.097  0 247 MET A C     1 ? 
ATOM   1970 O  O     . MET A 1 247 ? 5.490   -9.485  13.768  1.000 9.140  0 247 MET A O     1 ? 
ATOM   1971 C  CB    . MET A 1 247 ? 4.473   -6.391  13.140  1.000 9.408  0 247 MET A CB    1 ? 
ATOM   1972 C  CG    . MET A 1 247 ? 3.267   -5.730  12.559  1.000 9.549  0 247 MET A CG    1 ? 
ATOM   1973 S  SD    . MET A 1 247 ? 3.744   -4.350  11.421  1.000 13.699 0 247 MET A SD    1 ? 
ATOM   1974 C  CE    . MET A 1 247 ? 4.601   -5.139  10.124  1.000 18.642 0 247 MET A CE    1 ? 
ATOM   1975 N  N     . LEU A 1 248 ? 6.240   -7.914  15.194  1.000 8.238  0 248 LEU A N     1 ? 
ATOM   1976 C  CA    . LEU A 1 248 ? 7.494   -8.638  15.505  1.000 8.827  0 248 LEU A CA    1 ? 
ATOM   1977 C  C     . LEU A 1 248 ? 7.131   -10.018 16.070  1.000 9.820  0 248 LEU A C     1 ? 
ATOM   1978 O  O     . LEU A 1 248 ? 7.749   -11.037 15.621  1.000 11.178 0 248 LEU A O     1 ? 
ATOM   1979 C  CB    . LEU A 1 248 ? 8.307   -7.806  16.475  1.000 9.134  0 248 LEU A CB    1 ? 
ATOM   1980 C  CG    . LEU A 1 248 ? 9.085   -6.662  15.834  1.000 10.203 0 248 LEU A CG    1 ? 
ATOM   1981 C  CD1   . LEU A 1 248 ? 9.532   -5.690  16.858  1.000 10.555 0 248 LEU A CD1   1 ? 
ATOM   1982 C  CD2   . LEU A 1 248 ? 10.282  -7.211  15.044  1.000 10.131 0 248 LEU A CD2   1 ? 
ATOM   1983 N  N     . ASP A 1 249 ? 6.135   -10.056 16.943  1.000 8.803  0 249 ASP A N     1 ? 
ATOM   1984 C  CA    . ASP A 1 249 ? 5.718   -11.343 17.569  1.000 10.512 0 249 ASP A CA    1 ? 
ATOM   1985 C  C     . ASP A 1 249 ? 5.247   -12.335 16.509  1.000 11.914 0 249 ASP A C     1 ? 
ATOM   1986 O  O     . ASP A 1 249 ? 5.253   -13.590 16.803  1.000 14.025 0 249 ASP A O     1 ? 
ATOM   1987 C  CB    . ASP A 1 249 ? 4.603   -11.155 18.563  1.000 13.125 0 249 ASP A CB    1 ? 
ATOM   1988 C  CG    . ASP A 1 249 ? 4.973   -10.363 19.787  1.000 14.369 0 249 ASP A CG    1 ? 
ATOM   1989 O  OD1   . ASP A 1 249 ? 6.174   -10.237 20.079  1.000 16.662 0 249 ASP A OD1   1 ? 
ATOM   1990 O  OD2   . ASP A 1 249 ? 4.021   -9.897  20.441  1.000 18.990 0 249 ASP A OD2   1 ? 
ATOM   1991 N  N     . ASN A 1 250 ? 4.807   -11.901 15.335  1.000 9.913  0 250 ASN A N     1 ? 
ATOM   1992 C  CA    . ASN A 1 250 ? 4.256   -12.808 14.320  1.000 10.491 0 250 ASN A CA    1 ? 
ATOM   1993 C  C     . ASN A 1 250 ? 5.325   -13.272 13.308  1.000 10.285 0 250 ASN A C     1 ? 
ATOM   1994 O  O     . ASN A 1 250 ? 4.981   -14.006 12.378  1.000 13.161 0 250 ASN A O     1 ? 
ATOM   1995 C  CB    . ASN A 1 250 ? 3.046   -12.184 13.638  1.000 11.648 0 250 ASN A CB    1 ? 
ATOM   1996 C  CG    . ASN A 1 250 ? 1.812   -12.323 14.475  1.000 12.396 0 250 ASN A CG    1 ? 
ATOM   1997 O  OD1   . ASN A 1 250 ? 1.137   -13.374 14.383  1.000 14.822 0 250 ASN A OD1   1 ? 
ATOM   1998 N  ND2   . ASN A 1 250 ? 1.577   -11.363 15.343  1.000 13.020 0 250 ASN A ND2   1 ? 
ATOM   1999 N  N     . PHE A 1 251 ? 6.572   -12.796 13.410  1.000 10.807 0 251 PHE A N     1 ? 
ATOM   2000 C  CA    . PHE A 1 251 ? 7.665   -13.354 12.585  1.000 10.845 0 251 PHE A CA    1 ? 
ATOM   2001 C  C     . PHE A 1 251 ? 7.885   -14.798 13.050  1.000 13.536 0 251 PHE A C     1 ? 
ATOM   2002 O  O     . PHE A 1 251 ? 7.808   -15.054 14.257  1.000 15.784 0 251 PHE A O     1 ? 
ATOM   2003 C  CB    . PHE A 1 251 ? 8.944   -12.528 12.693  1.000 11.479 0 251 PHE A CB    1 ? 
ATOM   2004 C  CG    . PHE A 1 251 ? 8.987   -11.329 11.793  1.000 9.925  0 251 PHE A CG    1 ? 
ATOM   2005 C  CD1   . PHE A 1 251 ? 8.274   -10.198 12.144  1.000 9.996  0 251 PHE A CD1   1 ? 
ATOM   2006 C  CD2   . PHE A 1 251 ? 9.732   -11.295 10.621  1.000 10.225 0 251 PHE A CD2   1 ? 
ATOM   2007 C  CE1   . PHE A 1 251 ? 8.389   -9.038  11.405  1.000 8.893  0 251 PHE A CE1   1 ? 
ATOM   2008 C  CE2   . PHE A 1 251 ? 9.836   -10.133 9.882   1.000 9.698  0 251 PHE A CE2   1 ? 
ATOM   2009 C  CZ    . PHE A 1 251 ? 9.126   -9.026  10.241  1.000 8.516  0 251 PHE A CZ    1 ? 
ATOM   2010 N  N     . HIS A 1 252 ? 8.107   -15.688 12.129  1.000 12.846 0 252 HIS A N     1 ? 
ATOM   2011 C  CA    . HIS A 1 252 ? 8.305   -17.141 12.391  1.000 14.397 0 252 HIS A CA    1 ? 
ATOM   2012 C  C     . HIS A 1 252 ? 9.592   -17.565 11.687  1.000 12.609 0 252 HIS A C     1 ? 
ATOM   2013 O  O     . HIS A 1 252 ? 9.709   -17.365 10.509  1.000 11.637 0 252 HIS A O     1 ? 
ATOM   2014 C  CB    . HIS A 1 252 ? 7.068   -17.882 11.923  1.000 17.525 0 252 HIS A CB    1 ? 
ATOM   2015 C  CG    . HIS A 1 252 ? 7.132   -19.353 12.046  1.000 23.564 0 252 HIS A CG    1 ? 
ATOM   2016 N  ND1   . HIS A 1 252 ? 7.211   -20.186 10.926  1.000 29.615 0 252 HIS A ND1   1 ? 
ATOM   2017 C  CD2   . HIS A 1 252 ? 7.110   -20.158 13.128  1.000 27.983 0 252 HIS A CD2   1 ? 
ATOM   2018 C  CE1   . HIS A 1 252 ? 7.252   -21.443 11.330  1.000 27.732 0 252 HIS A CE1   1 ? 
ATOM   2019 N  NE2   . HIS A 1 252 ? 7.194   -21.455 12.676  1.000 27.754 0 252 HIS A NE2   1 ? 
ATOM   2020 N  N     . ASP A 1 253 ? 10.507  -18.179 12.413  1.000 14.735 0 253 ASP A N     1 ? 
ATOM   2021 C  CA    . ASP A 1 253 ? 11.719  -18.767 11.811  1.000 14.689 0 253 ASP A CA    1 ? 
ATOM   2022 C  C     . ASP A 1 253 ? 11.310  -19.884 10.865  1.000 14.524 0 253 ASP A C     1 ? 
ATOM   2023 O  O     . ASP A 1 253 ? 10.627  -20.807 11.291  1.000 17.054 0 253 ASP A O     1 ? 
ATOM   2024 C  CB    . ASP A 1 253 ? 12.664  -19.244 12.895  1.000 16.410 0 253 ASP A CB    1 ? 
ATOM   2025 C  CG    . ASP A 1 253 ? 13.218  -18.123 13.745  1.000 20.375 0 253 ASP A CG    1 ? 
ATOM   2026 O  OD1   . ASP A 1 253 ? 13.320  -16.945 13.237  1.000 18.787 0 253 ASP A OD1   1 ? 
ATOM   2027 O  OD2   . ASP A 1 253 ? 13.517  -18.399 14.911  1.000 27.154 0 253 ASP A OD2   1 ? 
ATOM   2028 N  N     . THR A 1 254 ? 11.662  -19.740 9.614   1.000 12.007 0 254 THR A N     1 ? 
ATOM   2029 C  CA    . THR A 1 254 ? 11.197  -20.578 8.511   1.000 10.803 0 254 THR A CA    1 ? 
ATOM   2030 C  C     . THR A 1 254 ? 12.395  -21.179 7.801   1.000 10.951 0 254 THR A C     1 ? 
ATOM   2031 O  O     . THR A 1 254 ? 13.209  -20.444 7.214   1.000 10.827 0 254 THR A O     1 ? 
ATOM   2032 C  CB    . THR A 1 254 ? 10.350  -19.782 7.533   1.000 11.963 0 254 THR A CB    1 ? 
ATOM   2033 O  OG1   . THR A 1 254 ? 9.367   -19.121 8.337   1.000 13.048 0 254 THR A OG1   1 ? 
ATOM   2034 C  CG2   . THR A 1 254 ? 9.713   -20.635 6.474   1.000 12.628 0 254 THR A CG2   1 ? 
ATOM   2035 N  N     . TRP A 1 255 ? 12.533  -22.499 7.849   1.000 10.609 0 255 TRP A N     1 ? 
ATOM   2036 C  CA    . TRP A 1 255 ? 13.663  -23.188 7.206   1.000 10.679 0 255 TRP A CA    1 ? 
ATOM   2037 C  C     . TRP A 1 255 ? 13.559  -23.077 5.710   1.000 9.967  0 255 TRP A C     1 ? 
ATOM   2038 O  O     . TRP A 1 255 ? 12.480  -23.344 5.156   1.000 12.821 0 255 TRP A O     1 ? 
ATOM   2039 C  CB    . TRP A 1 255 ? 13.635  -24.651 7.616   1.000 9.157  0 255 TRP A CB    1 ? 
ATOM   2040 C  CG    . TRP A 1 255 ? 14.814  -25.420 7.133   1.000 9.959  0 255 TRP A CG    1 ? 
ATOM   2041 C  CD1   . TRP A 1 255 ? 14.804  -26.301 6.101   1.000 10.065 0 255 TRP A CD1   1 ? 
ATOM   2042 C  CD2   . TRP A 1 255 ? 16.169  -25.370 7.616   1.000 9.939  0 255 TRP A CD2   1 ? 
ATOM   2043 N  NE1   . TRP A 1 255 ? 16.030  -26.872 5.956   1.000 10.569 0 255 TRP A NE1   1 ? 
ATOM   2044 C  CE2   . TRP A 1 255 ? 16.885  -26.341 6.862   1.000 10.278 0 255 TRP A CE2   1 ? 
ATOM   2045 C  CE3   . TRP A 1 255 ? 16.812  -24.768 8.712   1.000 10.449 0 255 TRP A CE3   1 ? 
ATOM   2046 C  CZ2   . TRP A 1 255 ? 18.244  -26.597 7.084   1.000 11.129 0 255 TRP A CZ2   1 ? 
ATOM   2047 C  CZ3   . TRP A 1 255 ? 18.158  -25.013 8.925   1.000 11.622 0 255 TRP A CZ3   1 ? 
ATOM   2048 C  CH2   . TRP A 1 255 ? 18.851  -25.945 8.124   1.000 11.570 0 255 TRP A CH2   1 ? 
ATOM   2049 N  N     . ASP A 1 256 ? 14.674  -22.813 5.063   1.000 10.324 0 256 ASP A N     1 ? 
ATOM   2050 C  CA    . ASP A 1 256 ? 14.846  -22.826 3.615   1.000 10.412 0 256 ASP A CA    1 ? 
ATOM   2051 C  C     . ASP A 1 256 ? 15.809  -23.950 3.231   1.000 12.246 0 256 ASP A C     1 ? 
ATOM   2052 O  O     . ASP A 1 256 ? 16.964  -23.896 3.606   1.000 13.027 0 256 ASP A O     1 ? 
ATOM   2053 C  CB    . ASP A 1 256 ? 15.390  -21.468 3.118   1.000 12.850 0 256 ASP A CB    1 ? 
ATOM   2054 C  CG    . ASP A 1 256 ? 15.416  -21.399 1.610   1.000 15.156 0 256 ASP A CG    1 ? 
ATOM   2055 O  OD1   . ASP A 1 256 ? 16.443  -21.750 1.031   1.000 20.303 0 256 ASP A OD1   1 ? 
ATOM   2056 O  OD2   . ASP A 1 256 ? 14.326  -21.202 1.030   1.000 21.270 0 256 ASP A OD2   1 ? 
ATOM   2057 N  N     . SER A 1 257 ? 15.285  -24.993 2.628   1.000 13.727 0 257 SER A N     1 ? 
ATOM   2058 C  CA    . SER A 1 257 ? 16.084  -26.178 2.244   1.000 12.801 0 257 SER A CA    1 ? 
ATOM   2059 C  C     . SER A 1 257 ? 17.167  -25.827 1.213   1.000 15.910 0 257 SER A C     1 ? 
ATOM   2060 O  O     . SER A 1 257 ? 18.255  -26.431 1.299   1.000 18.011 0 257 SER A O     1 ? 
ATOM   2061 C  CB    . SER A 1 257 ? 15.178  -27.278 1.733   1.000 14.237 0 257 SER A CB    1 ? 
ATOM   2062 O  OG    . SER A 1 257 ? 14.425  -27.824 2.814   1.000 12.415 0 257 SER A OG    1 ? 
ATOM   2063 N  N     . LYS A 1 258 ? 16.887  -24.909 0.284   1.000 17.963 0 258 LYS A N     1 ? 
ATOM   2064 C  CA    . LYS A 1 258 ? 17.889  -24.512 -0.758  1.000 20.561 0 258 LYS A CA    1 ? 
ATOM   2065 C  C     . LYS A 1 258 ? 19.113  -23.911 -0.045  1.000 20.070 0 258 LYS A C     1 ? 
ATOM   2066 O  O     . LYS A 1 258 ? 20.226  -24.348 -0.327  1.000 20.008 0 258 LYS A O     1 ? 
ATOM   2067 C  CB    . LYS A 1 258 ? 17.253  -23.593 -1.805  1.000 24.804 0 258 LYS A CB    1 ? 
ATOM   2068 C  CG    . LYS A 1 258 ? 18.228  -22.925 -2.764  1.000 35.943 0 258 LYS A CG    1 ? 
ATOM   2069 C  CD    . LYS A 1 258 ? 18.871  -23.870 -3.742  1.000 41.866 0 258 LYS A CD    1 ? 
ATOM   2070 C  CE    . LYS A 1 258 ? 20.303  -23.482 -4.067  1.000 44.347 0 258 LYS A CE    1 ? 
ATOM   2071 N  NZ    . LYS A 1 258 ? 20.891  -24.392 -5.069  1.000 46.255 0 258 LYS A NZ    1 ? 
ATOM   2072 N  N     . ASP A 1 259 ? 18.915  -23.018 0.937   1.000 18.287 0 259 ASP A N     1 ? 
ATOM   2073 C  CA    . ASP A 1 259 ? 20.019  -22.318 1.631   1.000 15.058 0 259 ASP A CA    1 ? 
ATOM   2074 C  C     . ASP A 1 259 ? 20.498  -23.045 2.897   1.000 14.778 0 259 ASP A C     1 ? 
ATOM   2075 O  O     . ASP A 1 259 ? 21.480  -22.628 3.504   1.000 16.710 0 259 ASP A O     1 ? 
ATOM   2076 C  CB    . ASP A 1 259 ? 19.601  -20.891 1.964   1.000 17.423 0 259 ASP A CB    1 ? 
ATOM   2077 C  CG    . ASP A 1 259 ? 19.352  -20.028 0.751   1.000 19.956 0 259 ASP A CG    1 ? 
ATOM   2078 O  OD1   . ASP A 1 259 ? 19.676  -20.468 -0.389  1.000 20.498 0 259 ASP A OD1   1 ? 
ATOM   2079 O  OD2   . ASP A 1 259 ? 18.803  -18.937 0.937   1.000 20.307 0 259 ASP A OD2   1 ? 
ATOM   2080 N  N     . GLN A 1 260 ? 19.768  -24.061 3.367   1.000 14.232 0 260 GLN A N     1 ? 
ATOM   2081 C  CA    . GLN A 1 260 ? 20.152  -24.803 4.570   1.000 13.096 0 260 GLN A CA    1 ? 
ATOM   2082 C  C     . GLN A 1 260 ? 20.328  -23.836 5.744   1.000 11.863 0 260 GLN A C     1 ? 
ATOM   2083 O  O     . GLN A 1 260 ? 21.226  -23.967 6.574   1.000 13.838 0 260 GLN A O     1 ? 
ATOM   2084 C  CB    . GLN A 1 260 ? 21.389  -25.668 4.293   1.000 13.881 0 260 GLN A CB    1 ? 
ATOM   2085 C  CG    . GLN A 1 260 ? 21.099  -26.806 3.355   1.000 15.454 0 260 GLN A CG    1 ? 
ATOM   2086 C  CD    . GLN A 1 260 ? 20.276  -27.895 4.020   1.000 14.938 0 260 GLN A CD    1 ? 
ATOM   2087 O  OE1   . GLN A 1 260 ? 20.705  -28.490 4.984   1.000 18.205 0 260 GLN A OE1   1 ? 
ATOM   2088 N  NE2   . GLN A 1 260 ? 19.085  -28.086 3.529   1.000 15.088 0 260 GLN A NE2   1 ? 
ATOM   2089 N  N     . ARG A 1 261 ? 19.304  -22.994 5.929   1.000 11.665 0 261 ARG A N     1 ? 
ATOM   2090 C  CA    . ARG A 1 261 ? 19.217  -22.111 7.088   1.000 12.168 0 261 ARG A CA    1 ? 
ATOM   2091 C  C     . ARG A 1 261 ? 17.783  -21.585 7.207   1.000 9.212  0 261 ARG A C     1 ? 
ATOM   2092 O  O     . ARG A 1 261 ? 16.986  -21.807 6.250   1.000 9.976  0 261 ARG A O     1 ? 
ATOM   2093 C  CB    . ARG A 1 261 ? 20.202  -20.928 6.986   1.000 13.889 0 261 ARG A CB    1 ? 
ATOM   2094 C  CG    . ARG A 1 261 ? 19.932  -20.017 5.825   1.000 14.788 0 261 ARG A CG    1 ? 
ATOM   2095 C  CD    . ARG A 1 261 ? 20.605  -18.648 6.020   1.000 14.551 0 261 ARG A CD    1 ? 
ATOM   2096 N  NE    . ARG A 1 261 ? 19.884  -17.914 7.034   1.000 15.483 0 261 ARG A NE    1 ? 
ATOM   2097 C  CZ    . ARG A 1 261 ? 20.170  -16.667 7.415   1.000 14.367 0 261 ARG A CZ    1 ? 
ATOM   2098 N  NH1   . ARG A 1 261 ? 21.234  -16.056 6.906   1.000 16.094 0 261 ARG A NH1   1 ? 
ATOM   2099 N  NH2   . ARG A 1 261 ? 19.416  -16.076 8.308   1.000 13.065 0 261 ARG A NH2   1 ? 
ATOM   2100 N  N     . SER A 1 262 ? 17.500  -21.020 8.358   1.000 11.070 0 262 SER A N     1 ? 
ATOM   2101 C  CA    . SER A 1 262 ? 16.209  -20.383 8.676   1.000 10.531 0 262 SER A CA    1 ? 
ATOM   2102 C  C     . SER A 1 262 ? 16.323  -18.906 8.356   1.000 11.281 0 262 SER A C     1 ? 
ATOM   2103 O  O     . SER A 1 262 ? 17.381  -18.295 8.606   1.000 11.426 0 262 SER A O     1 ? 
ATOM   2104 C  CB    . SER A 1 262 ? 15.794  -20.569 10.077  1.000 12.900 0 262 SER A CB    1 ? 
ATOM   2105 O  OG    . SER A 1 262 ? 15.560  -21.950 10.351  1.000 18.664 0 262 SER A OG    1 ? 
ATOM   2106 N  N     . TYR A 1 263 ? 15.193  -18.353 7.965   1.000 9.967  0 263 TYR A N     1 ? 
ATOM   2107 C  CA    . TYR A 1 263 ? 14.978  -16.878 7.866   1.000 10.245 0 263 TYR A CA    1 ? 
ATOM   2108 C  C     . TYR A 1 263 ? 13.734  -16.542 8.648   1.000 11.757 0 263 TYR A C     1 ? 
ATOM   2109 O  O     . TYR A 1 263 ? 12.764  -17.282 8.604   1.000 11.005 0 263 TYR A O     1 ? 
ATOM   2110 C  CB    . TYR A 1 263 ? 14.811  -16.449 6.429   1.000 10.366 0 263 TYR A CB    1 ? 
ATOM   2111 C  CG    . TYR A 1 263 ? 15.983  -16.736 5.549   1.000 10.690 0 263 TYR A CG    1 ? 
ATOM   2112 C  CD1   . TYR A 1 263 ? 17.106  -15.918 5.594   1.000 11.786 0 263 TYR A CD1   1 ? 
ATOM   2113 C  CD2   . TYR A 1 263 ? 15.967  -17.770 4.602   1.000 11.750 0 263 TYR A CD2   1 ? 
ATOM   2114 C  CE1   . TYR A 1 263 ? 18.218  -16.192 4.812   1.000 12.421 0 263 TYR A CE1   1 ? 
ATOM   2115 C  CE2   . TYR A 1 263 ? 17.065  -18.022 3.781   1.000 11.299 0 263 TYR A CE2   1 ? 
ATOM   2116 C  CZ    . TYR A 1 263 ? 18.150  -17.165 3.825   1.000 13.651 0 263 TYR A CZ    1 ? 
ATOM   2117 O  OH    . TYR A 1 263 ? 19.218  -17.446 3.029   1.000 17.311 0 263 TYR A OH    1 ? 
ATOM   2118 N  N     . PRO A 1 264 ? 13.679  -15.395 9.322   1.000 10.745 0 264 PRO A N     1 ? 
ATOM   2119 C  CA    . PRO A 1 264 ? 12.483  -14.989 10.041  1.000 11.583 0 264 PRO A CA    1 ? 
ATOM   2120 C  C     . PRO A 1 264 ? 11.499  -14.380 9.067   1.000 13.511 0 264 PRO A C     1 ? 
ATOM   2121 O  O     . PRO A 1 264 ? 11.818  -13.302 8.569   1.000 15.226 0 264 PRO A O     1 ? 
ATOM   2122 C  CB    . PRO A 1 264 ? 12.987  -13.946 11.031  1.000 13.800 0 264 PRO A CB    1 ? 
ATOM   2123 C  CG    . PRO A 1 264 ? 14.219  -13.367 10.375  1.000 13.536 0 264 PRO A CG    1 ? 
ATOM   2124 C  CD    . PRO A 1 264 ? 14.777  -14.418 9.437   1.000 12.231 0 264 PRO A CD    1 ? 
ATOM   2125 N  N     . ARG A 1 265 ? 10.297  -14.921 8.966   1.000 9.972  0 265 ARG A N     1 ? 
ATOM   2126 C  CA    . ARG A 1 265 ? 9.322   -14.488 7.944   1.000 10.534 0 265 ARG A CA    1 ? 
ATOM   2127 C  C     . ARG A 1 265 ? 8.023   -14.048 8.608   1.000 10.317 0 265 ARG A C     1 ? 
ATOM   2128 O  O     . ARG A 1 265 ? 7.480   -14.711 9.520   1.000 10.836 0 265 ARG A O     1 ? 
ATOM   2129 C  CB    . ARG A 1 265 ? 9.001   -15.584 6.959   1.000 11.195 0 265 ARG A CB    1 ? 
ATOM   2130 C  CG    . ARG A 1 265 ? 10.173  -15.977 6.061   1.000 12.052 0 265 ARG A CG    1 ? 
ATOM   2131 C  CD    . ARG A 1 265 ? 9.753   -16.664 4.805   1.000 12.335 0 265 ARG A CD    1 ? 
ATOM   2132 N  NE    . ARG A 1 265 ? 8.927   -15.810 4.004   1.000 12.513 0 265 ARG A NE    1 ? 
ATOM   2133 C  CZ    . ARG A 1 265 ? 9.347   -14.999 3.043   1.000 11.524 0 265 ARG A CZ    1 ? 
ATOM   2134 N  NH1   . ARG A 1 265 ? 10.640  -14.992 2.709   1.000 10.522 0 265 ARG A NH1   1 ? 
ATOM   2135 N  NH2   . ARG A 1 265 ? 8.513   -14.139 2.459   1.000 11.964 0 265 ARG A NH2   1 ? 
ATOM   2136 N  N     . LEU A 1 266 ? 7.543   -12.918 8.162   1.000 9.152  0 266 LEU A N     1 ? 
ATOM   2137 C  CA    . LEU A 1 266 ? 6.207   -12.426 8.517   1.000 9.312  0 266 LEU A CA    1 ? 
ATOM   2138 C  C     . LEU A 1 266 ? 5.240   -12.731 7.384   1.000 9.705  0 266 LEU A C     1 ? 
ATOM   2139 O  O     . LEU A 1 266 ? 5.450   -12.252 6.251   1.000 9.610  0 266 LEU A O     1 ? 
ATOM   2140 C  CB    . LEU A 1 266 ? 6.287   -10.923 8.795   1.000 8.660  0 266 LEU A CB    1 ? 
ATOM   2141 C  CG    . LEU A 1 266 ? 4.955   -10.284 9.184   1.000 8.656  0 266 LEU A CG    1 ? 
ATOM   2142 C  CD1   . LEU A 1 266 ? 4.467   -10.765 10.532  1.000 9.879  0 266 LEU A CD1   1 ? 
ATOM   2143 C  CD2   . LEU A 1 266 ? 5.094   -8.751  9.233   1.000 10.066 0 266 LEU A CD2   1 ? 
ATOM   2144 N  N     . THR A 1 267 ? 4.238   -13.573 7.661   1.000 9.156  0 267 THR A N     1 ? 
ATOM   2145 C  CA    . THR A 1 267 ? 3.154   -13.872 6.739   1.000 10.674 0 267 THR A CA    1 ? 
ATOM   2146 C  C     . THR A 1 267 ? 1.986   -12.938 7.052   1.000 9.519  0 267 THR A C     1 ? 
ATOM   2147 O  O     . THR A 1 267 ? 1.571   -12.884 8.244   1.000 12.874 0 267 THR A O     1 ? 
ATOM   2148 C  CB    . THR A 1 267 ? 2.737   -15.351 6.859   1.000 12.583 0 267 THR A CB    1 ? 
ATOM   2149 O  OG1   . THR A 1 267 ? 3.875   -16.140 6.529   1.000 15.666 0 267 THR A OG1   1 ? 
ATOM   2150 C  CG2   . THR A 1 267 ? 1.583   -15.689 5.946   1.000 14.137 0 267 THR A CG2   1 ? 
ATOM   2151 N  N     . VAL A 1 268 ? 1.498   -12.230 6.053   1.000 11.383 0 268 VAL A N     1 ? 
ATOM   2152 C  CA    . VAL A 1 268 ? 0.301   -11.359 6.221   1.000 11.364 0 268 VAL A CA    1 ? 
ATOM   2153 C  C     . VAL A 1 268 ? -0.673  -11.695 5.104   1.000 11.484 0 268 VAL A C     1 ? 
ATOM   2154 O  O     . VAL A 1 268 ? -0.470  -11.249 3.969   1.000 11.040 0 268 VAL A O     1 ? 
ATOM   2155 C  CB    . VAL A 1 268 ? 0.677   -9.872  6.225   1.000 13.290 0 268 VAL A CB    1 ? 
ATOM   2156 C  CG1   . VAL A 1 268 ? -0.560  -8.986  6.323   1.000 15.208 0 268 VAL A CG1   1 ? 
ATOM   2157 C  CG2   . VAL A 1 268 ? 1.661   -9.518  7.323   1.000 13.605 0 268 VAL A CG2   1 ? 
ATOM   2158 N  N     . GLU A 1 269 ? -1.668  -12.502 5.424   1.000 12.855 0 269 GLU A N     1 ? 
ATOM   2159 C  CA    . GLU A 1 269 ? -2.680  -12.907 4.434   1.000 14.244 0 269 GLU A CA    1 ? 
ATOM   2160 C  C     . GLU A 1 269 ? -3.655  -11.756 4.212   1.000 11.670 0 269 GLU A C     1 ? 
ATOM   2161 O  O     . GLU A 1 269 ? -4.085  -11.155 5.193   1.000 13.024 0 269 GLU A O     1 ? 
ATOM   2162 C  CB    . GLU A 1 269 ? -3.412  -14.139 4.915   1.000 18.414 0 269 GLU A CB    1 ? 
ATOM   2163 C  CG    . GLU A 1 269 ? -2.554  -15.380 4.854   1.000 25.396 0 269 GLU A CG    1 ? 
ATOM   2164 C  CD    . GLU A 1 269 ? -3.304  -16.633 5.247   1.000 35.834 0 269 GLU A CD    1 ? 
ATOM   2165 O  OE1   . GLU A 1 269 ? -4.548  -16.539 5.465   1.000 41.716 0 269 GLU A OE1   1 ? 
ATOM   2166 O  OE2   . GLU A 1 269 ? -2.657  -17.685 5.345   1.000 50.097 0 269 GLU A OE2   1 ? 
ATOM   2167 N  N     . LEU A 1 270 ? -4.043  -11.541 2.979   1.000 11.160 0 270 LEU A N     1 ? 
ATOM   2168 C  CA    . LEU A 1 270 ? -5.163  -10.621 2.687   1.000 12.365 0 270 LEU A CA    1 ? 
ATOM   2169 C  C     . LEU A 1 270 ? -6.366  -11.186 3.402   1.000 11.010 0 270 LEU A C     1 ? 
ATOM   2170 O  O     . LEU A 1 270 ? -6.607  -12.395 3.384   1.000 12.479 0 270 LEU A O     1 ? 
ATOM   2171 C  CB    . LEU A 1 270 ? -5.411  -10.533 1.184   1.000 15.380 0 270 LEU A CB    1 ? 
ATOM   2172 C  CG    . LEU A 1 270 ? -4.615  -9.524  0.373   1.000 20.293 0 270 LEU A CG    1 ? 
ATOM   2173 C  CD1   . LEU A 1 270 ? -5.232  -9.436  -1.025  1.000 22.928 0 270 LEU A CD1   1 ? 
ATOM   2174 C  CD2   . LEU A 1 270 ? -4.583  -8.151  1.016   1.000 19.085 0 270 LEU A CD2   1 ? 
ATOM   2175 N  N     . PRO A 1 271 ? -7.243  -10.340 3.967   1.000 10.192 0 271 PRO A N     1 ? 
ATOM   2176 C  CA    . PRO A 1 271 ? -8.493  -10.803 4.568   1.000 10.951 0 271 PRO A CA    1 ? 
ATOM   2177 C  C     . PRO A 1 271 ? -9.643  -11.025 3.584   1.000 11.351 0 271 PRO A C     1 ? 
ATOM   2178 O  O     . PRO A 1 271 ? -10.720 -11.301 4.058   1.000 12.252 0 271 PRO A O     1 ? 
ATOM   2179 C  CB    . PRO A 1 271 ? -8.846  -9.649  5.504   1.000 10.131 0 271 PRO A CB    1 ? 
ATOM   2180 C  CG    . PRO A 1 271 ? -8.325  -8.459  4.804   1.000 10.202 0 271 PRO A CG    1 ? 
ATOM   2181 C  CD    . PRO A 1 271 ? -7.007  -8.899  4.202   1.000 10.433 0 271 PRO A CD    1 ? 
ATOM   2182 N  N     . VAL A 1 272 ? -9.398  -10.873 2.299   1.000 10.916 0 272 VAL A N     1 ? 
ATOM   2183 C  CA    . VAL A 1 272 ? -10.398 -11.115 1.205   1.000 11.228 0 272 VAL A CA    1 ? 
ATOM   2184 C  C     . VAL A 1 272 ? -9.708  -11.877 0.094   1.000 12.267 0 272 VAL A C     1 ? 
ATOM   2185 O  O     . VAL A 1 272 ? -8.447  -11.986 0.129   1.000 11.759 0 272 VAL A O     1 ? 
ATOM   2186 C  CB    . VAL A 1 272 ? -11.015 -9.810  0.676   1.000 11.529 0 272 VAL A CB    1 ? 
ATOM   2187 C  CG1   . VAL A 1 272 ? -11.748 -9.053  1.756   1.000 13.911 0 272 VAL A CG1   1 ? 
ATOM   2188 C  CG2   . VAL A 1 272 ? -9.983  -8.905  0.028   1.000 12.863 0 272 VAL A CG2   1 ? 
ATOM   2189 N  N     . GLN A 1 273 ? -10.430 -12.285 -0.933  1.000 12.849 0 273 GLN A N     1 ? 
ATOM   2190 C  CA    . GLN A 1 273 ? -9.833  -12.987 -2.093  1.000 14.277 0 273 GLN A CA    1 ? 
ATOM   2191 C  C     . GLN A 1 273 ? -8.722  -12.152 -2.665  1.000 13.427 0 273 GLN A C     1 ? 
ATOM   2192 O  O     . GLN A 1 273 ? -8.866  -10.946 -2.835  1.000 14.718 0 273 GLN A O     1 ? 
ATOM   2193 C  CB    . GLN A 1 273 ? -10.886 -13.266 -3.159  1.000 16.869 0 273 GLN A CB    1 ? 
ATOM   2194 C  CG    . GLN A 1 273 ? -11.874 -14.322 -2.734  1.000 20.002 0 273 GLN A CG    1 ? 
ATOM   2195 C  CD    . GLN A 1 273 ? -11.358 -15.713 -2.987  1.000 23.305 0 273 GLN A CD    1 ? 
ATOM   2196 O  OE1   . GLN A 1 273 ? -10.167 -15.935 -3.198  1.000 24.811 0 273 GLN A OE1   1 ? 
ATOM   2197 N  NE2   . GLN A 1 273 ? -12.250 -16.679 -2.926  1.000 28.717 0 273 GLN A NE2   1 ? 
ATOM   2198 N  N     . PRO A 1 274 ? -7.563  -12.756 -3.043  1.000 14.599 0 274 PRO A N     1 ? 
ATOM   2199 C  CA    . PRO A 1 274 ? -7.370  -14.205 -3.014  1.000 14.841 0 274 PRO A CA    1 ? 
ATOM   2200 C  C     . PRO A 1 274 ? -6.691  -14.797 -1.771  1.000 16.421 0 274 PRO A C     1 ? 
ATOM   2201 O  O     . PRO A 1 274 ? -6.246  -15.968 -1.797  1.000 17.658 0 274 PRO A O     1 ? 
ATOM   2202 C  CB    . PRO A 1 274 ? -6.456  -14.411 -4.217  1.000 15.204 0 274 PRO A CB    1 ? 
ATOM   2203 C  CG    . PRO A 1 274 ? -5.596  -13.151 -4.266  1.000 16.749 0 274 PRO A CG    1 ? 
ATOM   2204 C  CD    . PRO A 1 274 ? -6.490  -12.049 -3.746  1.000 16.810 0 274 PRO A CD    1 ? 
ATOM   2205 N  N     . TYR A 1 275 ? -6.650  -14.036 -0.673  1.000 12.469 0 275 TYR A N     1 ? 
ATOM   2206 C  CA    . TYR A 1 275 ? -6.195  -14.512 0.651   1.000 13.501 0 275 TYR A CA    1 ? 
ATOM   2207 C  C     . TYR A 1 275 ? -4.715  -14.899 0.589   1.000 13.262 0 275 TYR A C     1 ? 
ATOM   2208 O  O     . TYR A 1 275 ? -4.320  -15.703 1.368   1.000 16.707 0 275 TYR A O     1 ? 
ATOM   2209 C  CB    . TYR A 1 275 ? -7.033  -15.700 1.131   1.000 14.753 0 275 TYR A CB    1 ? 
ATOM   2210 C  CG    . TYR A 1 275 ? -8.513  -15.418 1.251   1.000 15.423 0 275 TYR A CG    1 ? 
ATOM   2211 C  CD1   . TYR A 1 275 ? -9.024  -14.705 2.309   1.000 15.751 0 275 TYR A CD1   1 ? 
ATOM   2212 C  CD2   . TYR A 1 275 ? -9.414  -15.950 0.337   1.000 17.556 0 275 TYR A CD2   1 ? 
ATOM   2213 C  CE1   . TYR A 1 275 ? -10.389 -14.472 2.442   1.000 16.962 0 275 TYR A CE1   1 ? 
ATOM   2214 C  CE2   . TYR A 1 275 ? -10.780 -15.700 0.437   1.000 18.018 0 275 TYR A CE2   1 ? 
ATOM   2215 C  CZ    . TYR A 1 275 ? -11.266 -15.010 1.525   1.000 19.424 0 275 TYR A CZ    1 ? 
ATOM   2216 O  OH    . TYR A 1 275 ? -12.611 -14.753 1.634   1.000 21.247 0 275 TYR A OH    1 ? 
ATOM   2217 N  N     . ASN A 1 276 ? -3.960  -14.277 -0.300  1.000 13.743 0 276 ASN A N     1 ? 
ATOM   2218 C  CA    . ASN A 1 276 ? -2.521  -14.564 -0.441  1.000 12.676 0 276 ASN A CA    1 ? 
ATOM   2219 C  C     . ASN A 1 276 ? -1.741  -13.846 0.653   1.000 12.251 0 276 ASN A C     1 ? 
ATOM   2220 O  O     . ASN A 1 276 ? -2.175  -12.794 1.125   1.000 12.742 0 276 ASN A O     1 ? 
ATOM   2221 C  CB    . ASN A 1 276 ? -2.017  -14.193 -1.805  1.000 15.488 0 276 ASN A CB    1 ? 
ATOM   2222 C  CG    . ASN A 1 276 ? -2.125  -12.722 -2.082  1.000 17.345 0 276 ASN A CG    1 ? 
ATOM   2223 O  OD1   . ASN A 1 276 ? -3.224  -12.158 -2.118  1.000 17.861 0 276 ASN A OD1   1 ? 
ATOM   2224 N  ND2   . ASN A 1 276 ? -0.981  -12.084 -2.306  1.000 22.527 0 276 ASN A ND2   1 ? 
ATOM   2225 N  N     . ASP A 1 277 ? -0.559  -14.359 0.947   1.000 11.626 0 277 ASP A N     1 ? 
ATOM   2226 C  CA    . ASP A 1 277 ? 0.467   -13.682 1.787   1.000 11.187 0 277 ASP A CA    1 ? 
ATOM   2227 C  C     . ASP A 1 277 ? 1.068   -12.511 0.997   1.000 11.811 0 277 ASP A C     1 ? 
ATOM   2228 O  O     . ASP A 1 277 ? 1.764   -12.733 0.004   1.000 11.359 0 277 ASP A O     1 ? 
ATOM   2229 C  CB    . ASP A 1 277 ? 1.546   -14.662 2.205   1.000 11.736 0 277 ASP A CB    1 ? 
ATOM   2230 C  CG    . ASP A 1 277 ? 2.737   -13.992 2.818   1.000 12.569 0 277 ASP A CG    1 ? 
ATOM   2231 O  OD1   . ASP A 1 277 ? 2.600   -12.883 3.353   1.000 11.228 0 277 ASP A OD1   1 ? 
ATOM   2232 O  OD2   . ASP A 1 277 ? 3.782   -14.681 2.888   1.000 12.972 0 277 ASP A OD2   1 ? 
ATOM   2233 N  N     . VAL A 1 278 ? 0.767   -11.267 1.341   1.000 13.447 0 278 VAL A N     1 ? 
ATOM   2234 C  CA    . VAL A 1 278 ? 1.157   -10.165 0.465   1.000 14.651 0 278 VAL A CA    1 ? 
ATOM   2235 C  C     . VAL A 1 278 ? 2.657   -9.930  0.585   1.000 14.084 0 278 VAL A C     1 ? 
ATOM   2236 O  O     . VAL A 1 278 ? 3.184   -9.232  -0.256  1.000 17.324 0 278 VAL A O     1 ? 
ATOM   2237 C  CB    . VAL A 1 278 ? 0.352   -8.907  0.757   1.000 18.499 0 278 VAL A CB    1 ? 
ATOM   2238 C  CG1   . VAL A 1 278 ? -1.090  -9.089  0.310   1.000 20.525 0 278 VAL A CG1   1 ? 
ATOM   2239 C  CG2   . VAL A 1 278 ? 0.426   -8.548  2.186   1.000 19.276 0 278 VAL A CG2   1 ? 
ATOM   2240 N  N     . PHE A 1 279 ? 3.322   -10.541 1.578   1.000 12.629 0 279 PHE A N     1 ? 
ATOM   2241 C  CA    . PHE A 1 279 ? 4.798   -10.432 1.747   1.000 13.168 0 279 PHE A CA    1 ? 
ATOM   2242 C  C     . PHE A 1 279 ? 5.515   -11.631 1.132   1.000 13.585 0 279 PHE A C     1 ? 
ATOM   2243 O  O     . PHE A 1 279 ? 6.748   -11.697 1.277   1.000 12.576 0 279 PHE A O     1 ? 
ATOM   2244 C  CB    . PHE A 1 279 ? 5.175   -10.290 3.220   1.000 13.276 0 279 PHE A CB    1 ? 
ATOM   2245 C  CG    . PHE A 1 279 ? 4.908   -8.929  3.816   1.000 14.132 0 279 PHE A CG    1 ? 
ATOM   2246 C  CD1   . PHE A 1 279 ? 5.009   -7.778  3.043   1.000 17.865 0 279 PHE A CD1   1 ? 
ATOM   2247 C  CD2   . PHE A 1 279 ? 4.467   -8.803  5.099   1.000 17.241 0 279 PHE A CD2   1 ? 
ATOM   2248 C  CE1   . PHE A 1 279 ? 4.679   -6.537  3.573   1.000 16.853 0 279 PHE A CE1   1 ? 
ATOM   2249 C  CE2   . PHE A 1 279 ? 4.176   -7.542  5.641   1.000 17.225 0 279 PHE A CE2   1 ? 
ATOM   2250 C  CZ    . PHE A 1 279 ? 4.334   -6.422  4.896   1.000 18.178 0 279 PHE A CZ    1 ? 
ATOM   2251 N  N     . GLU A 1 280 ? 4.840   -12.450 0.334   1.000 14.336 0 280 GLU A N     1 ? 
ATOM   2252 C  CA    . GLU A 1 280 ? 5.427   -13.709 -0.185  1.000 16.540 0 280 GLU A CA    1 ? 
ATOM   2253 C  C     . GLU A 1 280 ? 6.640   -13.430 -1.086  1.000 15.972 0 280 GLU A C     1 ? 
ATOM   2254 O  O     . GLU A 1 280 ? 7.516   -14.306 -1.117  1.000 19.083 0 280 GLU A O     1 ? 
ATOM   2255 C  CB    . GLU A 1 280 ? 4.373   -14.545 -0.897  1.000 16.935 0 280 GLU A CB    1 ? 
ATOM   2256 C  CG    . GLU A 1 280 ? 3.764   -13.900 -2.091  1.000 20.350 0 280 GLU A CG    1 ? 
ATOM   2257 C  CD    . GLU A 1 280 ? 2.478   -14.588 -2.529  1.000 24.734 0 280 GLU A CD    1 ? 
ATOM   2258 O  OE1   . GLU A 1 280 ? 2.283   -15.764 -2.143  1.000 29.580 0 280 GLU A OE1   1 ? 
ATOM   2259 O  OE2   . GLU A 1 280 ? 1.645   -13.921 -3.135  1.000 26.199 0 280 GLU A OE2   1 ? 
ATOM   2260 N  N     . LYS A 1 281 ? 6.706   -12.304 -1.780  1.000 16.336 0 281 LYS A N     1 ? 
ATOM   2261 C  CA    . LYS A 1 281 ? 7.801   -12.058 -2.766  1.000 18.361 0 281 LYS A CA    1 ? 
ATOM   2262 C  C     . LYS A 1 281 ? 9.066   -11.571 -2.037  1.000 16.142 0 281 LYS A C     1 ? 
ATOM   2263 O  O     . LYS A 1 281 ? 10.160  -11.591 -2.676  1.000 16.473 0 281 LYS A O     1 ? 
ATOM   2264 C  CB    . LYS A 1 281 ? 7.380   -11.060 -3.840  1.000 22.977 0 281 LYS A CB    1 ? 
ATOM   2265 C  CG    . LYS A 1 281 ? 6.137   -11.454 -4.617  1.000 28.334 0 281 LYS A CG    1 ? 
ATOM   2266 C  CD    . LYS A 1 281 ? 6.194   -12.854 -5.243  1.000 35.032 0 281 LYS A CD    1 ? 
ATOM   2267 C  CE    . LYS A 1 281 ? 5.106   -13.063 -6.284  1.000 40.909 0 281 LYS A CE    1 ? 
ATOM   2268 N  NZ    . LYS A 1 281 ? 4.959   -14.489 -6.654  1.000 46.560 0 281 LYS A NZ    1 ? 
ATOM   2269 N  N     . MET A 1 282 ? 8.971   -11.164 -0.765  1.000 12.712 0 282 MET A N     1 ? 
ATOM   2270 C  CA    . MET A 1 282 ? 10.165  -10.707 -0.034  1.000 13.536 0 282 MET A CA    1 ? 
ATOM   2271 C  C     . MET A 1 282 ? 11.042  -11.930 0.223   1.000 11.870 0 282 MET A C     1 ? 
ATOM   2272 O  O     . MET A 1 282 ? 10.521  -12.993 0.595   1.000 13.068 0 282 MET A O     1 ? 
ATOM   2273 C  CB    . MET A 1 282 ? 9.818   -9.980  1.270   1.000 13.009 0 282 MET A CB    1 ? 
ATOM   2274 C  CG    . MET A 1 282 ? 11.034  -9.264  1.919   1.000 16.433 0 282 MET A CG    1 ? 
ATOM   2275 S  SD    . MET A 1 282 ? 10.589  -8.277  3.385   1.000 16.325 0 282 MET A SD    1 ? 
ATOM   2276 C  CE    . MET A 1 282 ? 8.970   -7.856  2.680   1.000 12.836 0 282 MET A CE    1 ? 
ATOM   2277 N  N     . THR A 1 283 ? 12.342  -11.827 -0.074  1.000 11.119 0 283 THR A N     1 ? 
ATOM   2278 C  CA    . THR A 1 283 ? 13.265  -12.941 0.173   1.000 10.021 0 283 THR A CA    1 ? 
ATOM   2279 C  C     . THR A 1 283 ? 13.500  -13.138 1.683   1.000 9.653  0 283 THR A C     1 ? 
ATOM   2280 O  O     . THR A 1 283 ? 13.207  -12.248 2.494   1.000 8.884  0 283 THR A O     1 ? 
ATOM   2281 C  CB    . THR A 1 283 ? 14.605  -12.740 -0.523  1.000 11.429 0 283 THR A CB    1 ? 
ATOM   2282 O  OG1   . THR A 1 283 ? 15.289  -11.703 0.180   1.000 11.530 0 283 THR A OG1   1 ? 
ATOM   2283 C  CG2   . THR A 1 283 ? 14.471  -12.431 -1.996  1.000 12.522 0 283 THR A CG2   1 ? 
ATOM   2284 N  N     . GLY A 1 284 ? 14.073  -14.282 2.079   1.000 9.905  0 284 GLY A N     1 ? 
ATOM   2285 C  CA    . GLY A 1 284 ? 14.457  -14.514 3.471   1.000 9.246  0 284 GLY A CA    1 ? 
ATOM   2286 C  C     . GLY A 1 284 ? 15.400  -13.405 3.987   1.000 7.679  0 284 GLY A C     1 ? 
ATOM   2287 O  O     . GLY A 1 284 ? 15.275  -13.001 5.150   1.000 7.765  0 284 GLY A O     1 ? 
ATOM   2288 N  N     . MET A 1 285 ? 16.416  -13.069 3.201   1.000 9.454  0 285 MET A N     1 ? 
ATOM   2289 C  CA    . MET A 1 285 ? 17.408  -12.078 3.636   1.000 9.255  0 285 MET A CA    1 ? 
ATOM   2290 C  C     . MET A 1 285 ? 16.718  -10.714 3.767   1.000 8.802  0 285 MET A C     1 ? 
ATOM   2291 O  O     . MET A 1 285 ? 16.960  -10.028 4.761   1.000 8.691  0 285 MET A O     1 ? 
ATOM   2292 C  CB    . MET A 1 285 ? 18.572  -12.007 2.644   1.000 10.617 0 285 MET A CB    1 ? 
ATOM   2293 C  CG    . MET A 1 285 ? 19.528  -13.225 2.767   1.000 12.292 0 285 MET A CG    1 ? 
ATOM   2294 S  SD    . MET A 1 285 ? 20.316  -13.288 4.274   1.000 13.708 0 285 MET A SD    1 ? 
ATOM   2295 C  CE    . MET A 1 285 ? 21.618  -12.058 4.010   1.000 14.438 0 285 MET A CE    1 ? 
ATOM   2296 N  N     . GLN A 1 286 ? 15.793  -10.416 2.902   1.000 9.217  0 286 GLN A N     1 ? 
ATOM   2297 C  CA    . GLN A 1 286 ? 15.027  -9.143  2.990   1.000 8.510  0 286 GLN A CA    1 ? 
ATOM   2298 C  C     . GLN A 1 286 ? 14.105  -9.188  4.189   1.000 8.182  0 286 GLN A C     1 ? 
ATOM   2299 O  O     . GLN A 1 286 ? 14.005  -8.169  4.908   1.000 7.878  0 286 GLN A O     1 ? 
ATOM   2300 C  CB    . GLN A 1 286 ? 14.240  -8.882  1.738   1.000 9.387  0 286 GLN A CB    1 ? 
ATOM   2301 C  CG    . GLN A 1 286 ? 15.143  -8.555  0.559   1.000 10.814 0 286 GLN A CG    1 ? 
ATOM   2302 C  CD    . GLN A 1 286 ? 14.441  -8.642  -0.772  1.000 13.173 0 286 GLN A CD    1 ? 
ATOM   2303 O  OE1   . GLN A 1 286 ? 13.329  -9.156  -0.915  1.000 12.471 0 286 GLN A OE1   1 ? 
ATOM   2304 N  NE2   . GLN A 1 286 ? 15.103  -8.096  -1.795  1.000 14.983 0 286 GLN A NE2   1 ? 
ATOM   2305 N  N     . MET A 1 287 ? 13.542  -10.332 4.495   1.000 7.183  0 287 MET A N     1 ? 
ATOM   2306 C  CA    . MET A 1 287 ? 12.753  -10.485 5.734   1.000 7.195  0 287 MET A CA    1 ? 
ATOM   2307 C  C     . MET A 1 287 ? 13.588  -10.270 6.975   1.000 6.778  0 287 MET A C     1 ? 
ATOM   2308 O  O     . MET A 1 287 ? 13.112  -9.713  7.989   1.000 8.079  0 287 MET A O     1 ? 
ATOM   2309 C  CB    . MET A 1 287 ? 12.069  -11.855 5.761   1.000 8.649  0 287 MET A CB    1 ? 
ATOM   2310 C  CG    . MET A 1 287 ? 10.756  -11.828 5.068   1.000 8.737  0 287 MET A CG    1 ? 
ATOM   2311 S  SD    . MET A 1 287 ? 9.481   -11.069 6.032   1.000 9.656  0 287 MET A SD    1 ? 
ATOM   2312 C  CE    . MET A 1 287 ? 8.139   -10.954 4.859   1.000 11.567 0 287 MET A CE    1 ? 
ATOM   2313 N  N     . GLU A 1 288 ? 14.808  -10.809 6.995   1.000 7.661  0 288 GLU A N     1 ? 
ATOM   2314 C  CA    . GLU A 1 288 ? 15.687  -10.653 8.139   1.000 8.573  0 288 GLU A CA    1 ? 
ATOM   2315 C  C     . GLU A 1 288 ? 15.975  -9.152  8.360   1.000 7.079  0 288 GLU A C     1 ? 
ATOM   2316 O  O     . GLU A 1 288 ? 15.963  -8.712  9.501   1.000 8.472  0 288 GLU A O     1 ? 
ATOM   2317 C  CB    . GLU A 1 288 ? 16.944  -11.484 7.898   1.000 9.359  0 288 GLU A CB    1 ? 
ATOM   2318 C  CG    . GLU A 1 288 ? 17.929  -11.385 8.999   1.000 11.792 0 288 GLU A CG    1 ? 
ATOM   2319 C  CD    . GLU A 1 288 ? 19.143  -12.224 8.739   1.000 15.106 0 288 GLU A CD    1 ? 
ATOM   2320 O  OE1   . GLU A 1 288 ? 20.050  -11.742 8.047   1.000 14.592 0 288 GLU A OE1   1 ? 
ATOM   2321 O  OE2   . GLU A 1 288 ? 19.186  -13.358 9.263   1.000 15.442 0 288 GLU A OE2   1 ? 
ATOM   2322 N  N     . SER A 1 289 ? 16.255  -8.435  7.283   1.000 8.184  0 289 SER A N     1 ? 
ATOM   2323 C  CA    . SER A 1 289 ? 16.546  -6.992  7.346   1.000 7.778  0 289 SER A CA    1 ? 
ATOM   2324 C  C     . SER A 1 289 ? 15.282  -6.218  7.824   1.000 8.273  0 289 SER A C     1 ? 
ATOM   2325 O  O     . SER A 1 289 ? 15.384  -5.336  8.707   1.000 8.400  0 289 SER A O     1 ? 
ATOM   2326 C  CB    . SER A 1 289 ? 17.070  -6.499  6.082   1.000 9.197  0 289 SER A CB    1 ? 
ATOM   2327 O  OG    . SER A 1 289 ? 17.546  -5.155  6.268   1.000 10.274 0 289 SER A OG    1 ? 
ATOM   2328 N  N     . PHE A 1 290 ? 14.145  -6.612  7.351   1.000 8.316  0 290 PHE A N     1 ? 
ATOM   2329 C  CA    . PHE A 1 290 ? 12.842  -6.013  7.732   1.000 7.193  0 290 PHE A CA    1 ? 
ATOM   2330 C  C     . PHE A 1 290 ? 12.616  -6.184  9.238   1.000 7.499  0 290 PHE A C     1 ? 
ATOM   2331 O  O     . PHE A 1 290 ? 12.352  -5.231  9.959   1.000 6.609  0 290 PHE A O     1 ? 
ATOM   2332 C  CB    . PHE A 1 290 ? 11.756  -6.664  6.882   1.000 7.277  0 290 PHE A CB    1 ? 
ATOM   2333 C  CG    . PHE A 1 290 ? 10.317  -6.296  7.182   1.000 7.593  0 290 PHE A CG    1 ? 
ATOM   2334 C  CD1   . PHE A 1 290 ? 9.938   -5.077  7.729   1.000 8.271  0 290 PHE A CD1   1 ? 
ATOM   2335 C  CD2   . PHE A 1 290 ? 9.337   -7.202  6.834   1.000 9.632  0 290 PHE A CD2   1 ? 
ATOM   2336 C  CE1   . PHE A 1 290 ? 8.584   -4.816  7.962   1.000 8.646  0 290 PHE A CE1   1 ? 
ATOM   2337 C  CE2   . PHE A 1 290 ? 8.005   -6.919  7.016   1.000 10.676 0 290 PHE A CE2   1 ? 
ATOM   2338 C  CZ    . PHE A 1 290 ? 7.632   -5.720  7.557   1.000 10.073 0 290 PHE A CZ    1 ? 
ATOM   2339 N  N     . LYS A 1 291 ? 12.805  -7.429  9.737   1.000 6.893  0 291 LYS A N     1 ? 
ATOM   2340 C  CA    . LYS A 1 291 ? 12.656  -7.685  11.167  1.000 7.392  0 291 LYS A CA    1 ? 
ATOM   2341 C  C     . LYS A 1 291 ? 13.622  -6.815  11.969  1.000 7.330  0 291 LYS A C     1 ? 
ATOM   2342 O  O     . LYS A 1 291 ? 13.226  -6.245  12.965  1.000 7.448  0 291 LYS A O     1 ? 
ATOM   2343 C  CB    . LYS A 1 291 ? 12.835  -9.177  11.463  1.000 8.021  0 291 LYS A CB    1 ? 
ATOM   2344 C  CG    . LYS A 1 291 ? 12.387  -9.530  12.859  1.000 9.989  0 291 LYS A CG    1 ? 
ATOM   2345 C  CD    . LYS A 1 291 ? 12.567  -10.994 13.217  1.000 11.500 0 291 LYS A CD    1 ? 
ATOM   2346 C  CE    . LYS A 1 291 ? 11.989  -11.247 14.590  1.000 13.707 0 291 LYS A CE    1 ? 
ATOM   2347 N  NZ    . LYS A 1 291 ? 12.276  -12.627 15.073  1.000 17.684 0 291 LYS A NZ    1 ? 
ATOM   2348 N  N     . SER A 1 292 ? 14.892  -6.754  11.565  1.000 8.041  0 292 SER A N     1 ? 
ATOM   2349 C  CA    . SER A 1 292 ? 15.910  -5.996  12.312  1.000 9.040  0 292 SER A CA    1 ? 
ATOM   2350 C  C     . SER A 1 292 ? 15.514  -4.516  12.388  1.000 8.342  0 292 SER A C     1 ? 
ATOM   2351 O  O     . SER A 1 292 ? 15.621  -3.905  13.443  1.000 9.081  0 292 SER A O     1 ? 
ATOM   2352 C  CB    . SER A 1 292 ? 17.269  -6.164  11.688  1.000 10.994 0 292 SER A CB    1 ? 
ATOM   2353 O  OG    . SER A 1 292 ? 17.695  -7.532  11.827  1.000 17.466 0 292 SER A OG    1 ? 
ATOM   2354 N  N     . LYS A 1 293 ? 15.080  -3.959  11.272  1.000 8.183  0 293 LYS A N     1 ? 
ATOM   2355 C  CA    . LYS A 1 293 ? 14.714  -2.543  11.220  1.000 8.699  0 293 LYS A CA    1 ? 
ATOM   2356 C  C     . LYS A 1 293 ? 13.414  -2.303  12.029  1.000 7.800  0 293 LYS A C     1 ? 
ATOM   2357 O  O     . LYS A 1 293 ? 13.297  -1.278  12.701  1.000 7.674  0 293 LYS A O     1 ? 
ATOM   2358 C  CB    . LYS A 1 293 ? 14.626  -2.082  9.773   1.000 9.230  0 293 LYS A CB    1 ? 
ATOM   2359 C  CG    . LYS A 1 293 ? 15.996  -1.726  9.221   1.000 13.630 0 293 LYS A CG    1 ? 
ATOM   2360 C  CD    . LYS A 1 293 ? 15.917  -1.100  7.830   1.000 13.214 0 293 LYS A CD    1 ? 
ATOM   2361 C  CE    . LYS A 1 293 ? 15.877  -2.155  6.804   1.000 14.440 0 293 LYS A CE    1 ? 
ATOM   2362 N  NZ    . LYS A 1 293 ? 16.086  -1.636  5.428   1.000 11.395 0 293 LYS A NZ    1 ? 
ATOM   2363 N  N     . LEU A 1 294 ? 12.490  -3.238  12.017  1.000 7.433  0 294 LEU A N     1 ? 
ATOM   2364 C  CA    . LEU A 1 294 ? 11.271  -3.116  12.808  1.000 8.385  0 294 LEU A CA    1 ? 
ATOM   2365 C  C     . LEU A 1 294 ? 11.614  -3.176  14.276  1.000 7.762  0 294 LEU A C     1 ? 
ATOM   2366 O  O     . LEU A 1 294 ? 11.078  -2.400  15.083  1.000 7.642  0 294 LEU A O     1 ? 
ATOM   2367 C  CB    . LEU A 1 294 ? 10.372  -4.263  12.404  1.000 9.138  0 294 LEU A CB    1 ? 
ATOM   2368 C  CG    . LEU A 1 294 ? 8.925   -4.149  12.726  1.000 12.624 0 294 LEU A CG    1 ? 
ATOM   2369 C  CD1   . LEU A 1 294 ? 8.281   -2.894  12.111  1.000 11.232 0 294 LEU A CD1   1 ? 
ATOM   2370 C  CD2   . LEU A 1 294 ? 8.212   -5.382  12.196  1.000 13.790 0 294 LEU A CD2   1 ? 
ATOM   2371 N  N     . GLN A 1 295 ? 12.538  -4.063  14.653  1.000 7.609  0 295 GLN A N     1 ? 
ATOM   2372 C  CA    . GLN A 1 295 ? 12.980  -4.109  16.047  1.000 8.576  0 295 GLN A CA    1 ? 
ATOM   2373 C  C     . GLN A 1 295 ? 13.639  -2.777  16.431  1.000 7.702  0 295 GLN A C     1 ? 
ATOM   2374 O  O     . GLN A 1 295 ? 13.428  -2.300  17.556  1.000 8.645  0 295 GLN A O     1 ? 
ATOM   2375 C  CB    . GLN A 1 295 ? 13.898  -5.302  16.320  1.000 10.570 0 295 GLN A CB    1 ? 
ATOM   2376 C  CG    . GLN A 1 295 ? 14.278  -5.442  17.786  1.000 11.637 0 295 GLN A CG    1 ? 
ATOM   2377 C  CD    . GLN A 1 295 ? 13.153  -5.897  18.663  1.000 12.799 0 295 GLN A CD    1 ? 
ATOM   2378 O  OE1   . GLN A 1 295 ? 12.543  -6.930  18.396  1.000 16.436 0 295 GLN A OE1   1 ? 
ATOM   2379 N  NE2   . GLN A 1 295 ? 12.859  -5.120  19.685  1.000 14.210 0 295 GLN A NE2   1 ? 
ATOM   2380 N  N     . ALA A 1 296 ? 14.487  -2.216  15.571  1.000 8.112  0 296 ALA A N     1 ? 
ATOM   2381 C  CA    . ALA A 1 296 ? 15.112  -0.935  15.891  1.000 7.799  0 296 ALA A CA    1 ? 
ATOM   2382 C  C     . ALA A 1 296 ? 14.046  0.167   16.058  1.000 7.427  0 296 ALA A C     1 ? 
ATOM   2383 O  O     . ALA A 1 296 ? 14.201  1.004   16.932  1.000 8.316  0 296 ALA A O     1 ? 
ATOM   2384 C  CB    . ALA A 1 296 ? 16.121  -0.590  14.840  1.000 7.359  0 296 ALA A CB    1 ? 
ATOM   2385 N  N     . LEU A 1 297 ? 12.999  0.146   15.258  1.000 7.313  0 297 LEU A N     1 ? 
ATOM   2386 C  CA    . LEU A 1 297 ? 11.906  1.121   15.401  1.000 7.562  0 297 LEU A CA    1 ? 
ATOM   2387 C  C     . LEU A 1 297 ? 11.181  0.899   16.737  1.000 7.436  0 297 LEU A C     1 ? 
ATOM   2388 O  O     . LEU A 1 297 ? 10.934  1.904   17.422  1.000 7.977  0 297 LEU A O     1 ? 
ATOM   2389 C  CB    . LEU A 1 297 ? 10.970  1.023   14.199  1.000 6.677  0 297 LEU A CB    1 ? 
ATOM   2390 C  CG    . LEU A 1 297 ? 9.658   1.804   14.297  1.000 6.914  0 297 LEU A CG    1 ? 
ATOM   2391 C  CD1   . LEU A 1 297 ? 9.906   3.316   14.410  1.000 7.914  0 297 LEU A CD1   1 ? 
ATOM   2392 C  CD2   . LEU A 1 297 ? 8.750   1.471   13.141  1.000 7.826  0 297 LEU A CD2   1 ? 
ATOM   2393 N  N     . LEU A 1 298 ? 10.901  -0.345  17.101  1.000 8.208  0 298 LEU A N     1 ? 
ATOM   2394 C  CA    . LEU A 1 298 ? 10.262  -0.628  18.416  1.000 9.211  0 298 LEU A CA    1 ? 
ATOM   2395 C  C     . LEU A 1 298 ? 11.132  -0.023  19.512  1.000 9.761  0 298 LEU A C     1 ? 
ATOM   2396 O  O     . LEU A 1 298 ? 10.604  0.625   20.418  1.000 8.925  0 298 LEU A O     1 ? 
ATOM   2397 C  CB    . LEU A 1 298 ? 10.079  -2.138  18.586  1.000 9.786  0 298 LEU A CB    1 ? 
ATOM   2398 C  CG    . LEU A 1 298 ? 9.367   -2.612  19.842  1.000 12.429 0 298 LEU A CG    1 ? 
ATOM   2399 C  CD1   . LEU A 1 298 ? 10.272  -2.580  21.052  1.000 16.708 0 298 LEU A CD1   1 ? 
ATOM   2400 C  CD2   . LEU A 1 298 ? 8.089   -1.855  20.052  1.000 12.340 0 298 LEU A CD2   1 ? 
ATOM   2401 N  N     . ASN A 1 299 ? 12.438  -0.267  19.472  1.000 10.848 0 299 ASN A N     1 ? 
ATOM   2402 C  CA    . ASN A 1 299 ? 13.324  0.197   20.548  1.000 12.509 0 299 ASN A CA    1 ? 
ATOM   2403 C  C     . ASN A 1 299 ? 13.293  1.729   20.603  1.000 11.377 0 299 ASN A C     1 ? 
ATOM   2404 O  O     . ASN A 1 299 ? 13.231  2.262   21.686  1.000 12.489 0 299 ASN A O     1 ? 
ATOM   2405 C  CB    . ASN A 1 299 ? 14.757  -0.305  20.348  1.000 12.514 0 299 ASN A CB    1 ? 
ATOM   2406 C  CG    . ASN A 1 299 ? 14.909  -1.810  20.396  1.000 13.784 0 299 ASN A CG    1 ? 
ATOM   2407 O  OD1   . ASN A 1 299 ? 14.021  -2.525  20.813  1.000 16.019 0 299 ASN A OD1   1 ? 
ATOM   2408 N  ND2   . ASN A 1 299 ? 16.019  -2.284  19.863  1.000 16.585 0 299 ASN A ND2   1 ? 
ATOM   2409 N  N     . ALA A 1 300 ? 13.210  2.428   19.468  1.000 9.801  0 300 ALA A N     1 ? 
ATOM   2410 C  CA    . ALA A 1 300 ? 13.125  3.901   19.427  1.000 9.513  0 300 ALA A CA    1 ? 
ATOM   2411 C  C     . ALA A 1 300 ? 11.762  4.366   19.996  1.000 10.055 0 300 ALA A C     1 ? 
ATOM   2412 O  O     . ALA A 1 300 ? 11.722  5.370   20.724  1.000 11.379 0 300 ALA A O     1 ? 
ATOM   2413 C  CB    . ALA A 1 300 ? 13.285  4.365   18.018  1.000 9.909  0 300 ALA A CB    1 ? 
ATOM   2414 N  N     . LEU A 1 301 ? 10.686  3.668   19.704  1.000 8.132  0 301 LEU A N     1 ? 
ATOM   2415 C  CA    . LEU A 1 301 ? 9.364   4.027   20.253  1.000 9.089  0 301 LEU A CA    1 ? 
ATOM   2416 C  C     . LEU A 1 301 ? 9.405   3.917   21.775  1.000 9.260  0 301 LEU A C     1 ? 
ATOM   2417 O  O     . LEU A 1 301 ? 8.819   4.766   22.448  1.000 10.204 0 301 LEU A O     1 ? 
ATOM   2418 C  CB    . LEU A 1 301 ? 8.311   3.130   19.642  1.000 8.957  0 301 LEU A CB    1 ? 
ATOM   2419 C  CG    . LEU A 1 301 ? 7.968   3.451   18.163  1.000 8.933  0 301 LEU A CG    1 ? 
ATOM   2420 C  CD1   . LEU A 1 301 ? 7.213   2.301   17.535  1.000 8.778  0 301 LEU A CD1   1 ? 
ATOM   2421 C  CD2   . LEU A 1 301 ? 7.147   4.749   18.015  1.000 9.572  0 301 LEU A CD2   1 ? 
ATOM   2422 N  N     . LYS A 1 302 ? 10.068  2.882   22.304  1.000 10.734 0 302 LYS A N     1 ? 
ATOM   2423 C  CA    . LYS A 1 302 ? 10.159  2.727   23.790  1.000 13.021 0 302 LYS A CA    1 ? 
ATOM   2424 C  C     . LYS A 1 302 ? 11.058  3.834   24.342  1.000 14.067 0 302 LYS A C     1 ? 
ATOM   2425 O  O     . LYS A 1 302 ? 10.712  4.437   25.409  1.000 16.892 0 302 LYS A O     1 ? 
ATOM   2426 C  CB    . LYS A 1 302 ? 10.683  1.343   24.138  1.000 14.539 0 302 LYS A CB    1 ? 
ATOM   2427 C  CG    . LYS A 1 302 ? 9.686   0.242   23.936  1.000 17.142 0 302 LYS A CG    1 ? 
ATOM   2428 C  CD    . LYS A 1 302 ? 10.187  -1.109  24.345  1.000 20.104 0 302 LYS A CD    1 ? 
ATOM   2429 C  CE    . LYS A 1 302 ? 9.047   -2.042  24.656  1.000 25.661 0 302 LYS A CE    1 ? 
ATOM   2430 N  NZ    . LYS A 1 302 ? 9.547   -3.290  25.274  1.000 29.430 0 302 LYS A NZ    1 ? 
ATOM   2431 N  N     . THR A 1 303 ? 12.141  4.143   23.663  1.000 15.605 0 303 THR A N     1 ? 
ATOM   2432 C  CA    . THR A 1 303 ? 13.062  5.214   24.078  1.000 16.927 0 303 THR A CA    1 ? 
ATOM   2433 C  C     . THR A 1 303 ? 12.300  6.529   24.196  1.000 18.291 0 303 THR A C     1 ? 
ATOM   2434 O  O     . THR A 1 303 ? 12.556  7.277   25.153  1.000 19.788 0 303 THR A O     1 ? 
ATOM   2435 C  CB    . THR A 1 303 ? 14.248  5.343   23.112  1.000 18.240 0 303 THR A CB    1 ? 
ATOM   2436 O  OG1   . THR A 1 303 ? 14.987  4.120   23.206  1.000 22.363 0 303 THR A OG1   1 ? 
ATOM   2437 C  CG2   . THR A 1 303 ? 15.151  6.515   23.438  1.000 21.923 0 303 THR A CG2   1 ? 
ATOM   2438 N  N     . ALA A 1 304 ? 11.363  6.805   23.287  1.000 16.140 0 304 ALA A N     1 ? 
ATOM   2439 C  CA    . ALA A 1 304 ? 10.615  8.077   23.228  1.000 16.235 0 304 ALA A CA    1 ? 
ATOM   2440 C  C     . ALA A 1 304 ? 9.629   8.201   24.400  1.000 17.687 0 304 ALA A C     1 ? 
ATOM   2441 O  O     . ALA A 1 304 ? 9.010   9.299   24.566  1.000 18.319 0 304 ALA A O     1 ? 
ATOM   2442 C  CB    . ALA A 1 304 ? 9.877   8.173   21.925  1.000 17.544 0 304 ALA A CB    1 ? 
ATOM   2443 N  N     . LYS A 1 305 ? 9.328   7.109   25.062  1.000 16.142 0 305 LYS A N     1 ? 
ATOM   2444 C  CA    . LYS A 1 305 ? 8.500   7.127   26.279  1.000 19.617 0 305 LYS A CA    1 ? 
ATOM   2445 C  C     . LYS A 1 305 ? 9.374   7.536   27.485  1.000 23.397 0 305 LYS A C     1 ? 
ATOM   2446 O  O     . LYS A 1 305 ? 8.840   8.092   28.393  1.000 28.416 0 305 LYS A O     1 ? 
ATOM   2447 C  CB    . LYS A 1 305 ? 7.866   5.763   26.468  1.000 20.064 0 305 LYS A CB    1 ? 
ATOM   2448 C  CG    . LYS A 1 305 ? 6.761   5.691   27.505  1.000 22.016 0 305 LYS A CG    1 ? 
ATOM   2449 C  CD    . LYS A 1 305 ? 6.235   4.303   27.623  1.000 22.712 0 305 LYS A CD    1 ? 
ATOM   2450 C  CE    . LYS A 1 305 ? 4.946   4.182   28.393  1.000 24.786 0 305 LYS A CE    1 ? 
ATOM   2451 N  NZ    . LYS A 1 305 ? 4.501   2.768   28.419  1.000 28.274 0 305 LYS A NZ    1 ? 
ATOM   2452 N  N     . SER A 1 306 ? 10.668  7.250   27.465  1.000 26.685 0 306 SER A N     1 ? 
ATOM   2453 C  CA    . SER A 1 306 ? 11.528  7.289   28.684  1.000 32.191 0 306 SER A CA    1 ? 
ATOM   2454 C  C     . SER A 1 306 ? 12.357  8.591   28.765  1.000 42.072 0 306 SER A C     1 ? 
ATOM   2455 O  O     . SER A 1 306 ? 12.720  8.965   29.905  1.000 35.578 0 306 SER A O     1 ? 
ATOM   2456 C  CB    . SER A 1 306 ? 12.400  6.095   28.736  1.000 35.405 0 306 SER A CB    1 ? 
ATOM   2457 O  OG    . SER A 1 306 ? 13.452  6.214   27.804  1.000 40.910 0 306 SER A OG    1 ? 
ATOM   2458 N  N     . ARG A 1 307 ? 12.671  9.242   27.620  1.000 39.369 0 307 ARG A N     1 ? 
ATOM   2459 C  CA    . ARG A 1 307 ? 13.748  10.275  27.500  1.000 44.043 0 307 ARG A CA    1 ? 
ATOM   2460 C  C     . ARG A 1 307 ? 13.499  11.459  28.442  1.000 46.705 0 307 ARG A C     1 ? 
ATOM   2461 O  O     . ARG A 1 307 ? 14.491  12.091  28.848  1.000 52.215 0 307 ARG A O     1 ? 
ATOM   2462 C  CB    . ARG A 1 307 ? 13.883  10.807  26.069  1.000 41.372 0 307 ARG A CB    1 ? 
ATOM   2463 C  CG    . ARG A 1 307 ? 14.670  9.906   25.127  1.000 42.001 0 307 ARG A CG    1 ? 
ATOM   2464 C  CD    . ARG A 1 307 ? 15.907  9.302   25.745  1.000 41.841 0 307 ARG A CD    1 ? 
ATOM   2465 N  NE    . ARG A 1 307 ? 15.569  8.154   26.581  1.000 49.460 0 307 ARG A NE    1 ? 
ATOM   2466 C  CZ    . ARG A 1 307 ? 16.449  7.298   27.095  1.000 50.190 0 307 ARG A CZ    1 ? 
ATOM   2467 N  NH1   . ARG A 1 307 ? 16.025  6.288   27.836  1.000 51.214 0 307 ARG A NH1   1 ? 
ATOM   2468 N  NH2   . ARG A 1 307 ? 17.742  7.444   26.859  1.000 56.497 0 307 ARG A NH2   1 ? 
ATOM   2469 N  N     . LEU A 1 308 ? 12.246  11.828  28.671  1.000 48.105 0 308 LEU A N     1 ? 
ATOM   2470 C  CA    . LEU A 1 308 ? 11.878  12.995  29.512  1.000 54.408 0 308 LEU A CA    1 ? 
ATOM   2471 C  C     . LEU A 1 308 ? 12.178  14.293  28.754  1.000 50.784 0 308 LEU A C     1 ? 
ATOM   2472 O  O     . LEU A 1 308 ? 11.263  15.136  28.688  1.000 62.580 0 308 LEU A O     1 ? 
ATOM   2473 C  CB    . LEU A 1 308 ? 12.640  12.941  30.847  1.000 61.154 0 308 LEU A CB    1 ? 
ATOM   2474 C  CG    . LEU A 1 308 ? 11.871  12.330  32.022  1.000 62.413 0 308 LEU A CG    1 ? 
ATOM   2475 C  CD1   . LEU A 1 308 ? 12.817  11.895  33.127  1.000 61.738 0 308 LEU A CD1   1 ? 
ATOM   2476 C  CD2   . LEU A 1 308 ? 10.848  13.304  32.566  1.000 60.243 0 308 LEU A CD2   1 ? 
ATOM   2477 N  N     . GLU A 1 309 ? 13.405  14.472  28.230  1.000 36.235 0 309 GLU A N     1 ? 
ATOM   2478 C  CA    . GLU A 1 309 ? 13.745  15.653  27.392  1.000 28.024 0 309 GLU A CA    1 ? 
ATOM   2479 C  C     . GLU A 1 309 ? 13.088  15.486  26.016  1.000 22.278 0 309 GLU A C     1 ? 
ATOM   2480 O  O     . GLU A 1 309 ? 13.415  14.520  25.311  1.000 18.684 0 309 GLU A O     1 ? 
ATOM   2481 C  CB    . GLU A 1 309 ? 15.242  15.838  27.226  1.000 34.662 0 309 GLU A CB    1 ? 
ATOM   2482 C  CG    . GLU A 1 309 ? 15.604  17.211  26.720  1.000 38.822 0 309 GLU A CG    1 ? 
ATOM   2483 C  CD    . GLU A 1 309 ? 15.691  18.293  27.796  1.000 46.935 0 309 GLU A CD    1 ? 
ATOM   2484 O  OE1   . GLU A 1 309 ? 16.415  18.081  28.794  1.000 49.947 0 309 GLU A OE1   1 ? 
ATOM   2485 O  OE2   . GLU A 1 309 ? 15.042  19.354  27.626  1.000 46.275 0 309 GLU A OE2   1 ? 
ATOM   2486 N  N     . LEU A 1 310 ? 12.112  16.322  25.708  1.000 18.681 0 310 LEU A N     1 ? 
ATOM   2487 C  CA    . LEU A 1 310 ? 11.298  16.189  24.469  1.000 16.831 0 310 LEU A CA    1 ? 
ATOM   2488 C  C     . LEU A 1 310 ? 12.216  16.149  23.237  1.000 17.000 0 310 LEU A C     1 ? 
ATOM   2489 O  O     . LEU A 1 310 ? 11.939  15.318  22.331  1.000 12.770 0 310 LEU A O     1 ? 
ATOM   2490 C  CB    . LEU A 1 310 ? 10.281  17.332  24.400  1.000 17.585 0 310 LEU A CB    1 ? 
ATOM   2491 C  CG    . LEU A 1 310 ? 9.386   17.341  23.160  1.000 17.402 0 310 LEU A CG    1 ? 
ATOM   2492 C  CD1   . LEU A 1 310 ? 8.533   16.108  23.104  1.000 17.891 0 310 LEU A CD1   1 ? 
ATOM   2493 C  CD2   . LEU A 1 310 ? 8.512   18.579  23.124  1.000 19.984 0 310 LEU A CD2   1 ? 
ATOM   2494 N  N     . HIS A 1 311 ? 13.254  16.969  23.167  1.000 16.215 0 311 HIS A N     1 ? 
ATOM   2495 C  CA    . HIS A 1 311 ? 14.231  16.982  22.058  1.000 16.126 0 311 HIS A CA    1 ? 
ATOM   2496 C  C     . HIS A 1 311 ? 14.784  15.566  21.854  1.000 15.610 0 311 HIS A C     1 ? 
ATOM   2497 O  O     . HIS A 1 311 ? 14.768  15.096  20.701  1.000 14.591 0 311 HIS A O     1 ? 
ATOM   2498 C  CB    . HIS A 1 311 ? 15.394  17.928  22.377  1.000 17.318 0 311 HIS A CB    1 ? 
ATOM   2499 C  CG    . HIS A 1 311 ? 16.518  17.801  21.421  1.000 16.854 0 311 HIS A CG    1 ? 
ATOM   2500 N  ND1   . HIS A 1 311 ? 16.533  18.448  20.242  1.000 17.041 0 311 HIS A ND1   1 ? 
ATOM   2501 C  CD2   . HIS A 1 311 ? 17.600  17.005  21.423  1.000 19.569 0 311 HIS A CD2   1 ? 
ATOM   2502 C  CE1   . HIS A 1 311 ? 17.627  18.126  19.585  1.000 20.048 0 311 HIS A CE1   1 ? 
ATOM   2503 N  NE2   . HIS A 1 311 ? 18.270  17.259  20.270  1.000 19.272 0 311 HIS A NE2   1 ? 
ATOM   2504 N  N     . ASP A 1 312 ? 15.225  14.913  22.933  1.000 14.938 0 312 ASP A N     1 ? 
ATOM   2505 C  CA    . ASP A 1 312 ? 15.871  13.580  22.895  1.000 17.746 0 312 ASP A CA    1 ? 
ATOM   2506 C  C     . ASP A 1 312 ? 14.840  12.534  22.411  1.000 15.252 0 312 ASP A C     1 ? 
ATOM   2507 O  O     . ASP A 1 312 ? 15.200  11.692  21.596  1.000 16.696 0 312 ASP A O     1 ? 
ATOM   2508 C  CB    . ASP A 1 312 ? 16.468  13.210  24.249  1.000 19.150 0 312 ASP A CB    1 ? 
ATOM   2509 C  CG    . ASP A 1 312 ? 17.667  14.064  24.654  1.000 25.030 0 312 ASP A CG    1 ? 
ATOM   2510 O  OD1   . ASP A 1 312 ? 18.233  14.689  23.779  1.000 23.091 0 312 ASP A OD1   1 ? 
ATOM   2511 O  OD2   . ASP A 1 312 ? 17.948  14.144  25.881  1.000 30.029 0 312 ASP A OD2   1 ? 
ATOM   2512 N  N     . ALA A 1 313 ? 13.612  12.575  22.909  1.000 14.345 0 313 ALA A N     1 ? 
ATOM   2513 C  CA    . ALA A 1 313 ? 12.557  11.631  22.535  1.000 12.198 0 313 ALA A CA    1 ? 
ATOM   2514 C  C     . ALA A 1 313 ? 12.301  11.771  21.035  1.000 11.531 0 313 ALA A C     1 ? 
ATOM   2515 O  O     . ALA A 1 313 ? 12.176  10.759  20.343  1.000 11.506 0 313 ALA A O     1 ? 
ATOM   2516 C  CB    . ALA A 1 313 ? 11.310  11.931  23.303  1.000 12.341 0 313 ALA A CB    1 ? 
ATOM   2517 N  N     . CYS A 1 314 ? 12.176  12.990  20.544  1.000 10.779 0 314 CYS A N     1 ? 
ATOM   2518 C  CA    . CYS A 1 314 ? 11.816  13.244  19.138  1.000 10.587 0 314 CYS A CA    1 ? 
ATOM   2519 C  C     . CYS A 1 314 ? 12.985  12.894  18.214  1.000 11.490 0 314 CYS A C     1 ? 
ATOM   2520 O  O     . CYS A 1 314 ? 12.741  12.341  17.118  1.000 10.200 0 314 CYS A O     1 ? 
ATOM   2521 C  CB    . CYS A 1 314 ? 11.337  14.665  18.920  1.000 10.078 0 314 CYS A CB    1 ? 
ATOM   2522 S  SG    . CYS A 1 314 ? 9.756   14.996  19.748  1.000 11.639 0 314 CYS A SG    1 ? 
ATOM   2523 N  N     . LYS A 1 315 ? 14.209  13.187  18.608  1.000 12.238 0 315 LYS A N     1 ? 
ATOM   2524 C  CA    . LYS A 1 315 ? 15.399  12.825  17.836  1.000 12.680 0 315 LYS A CA    1 ? 
ATOM   2525 C  C     . LYS A 1 315 ? 15.450  11.295  17.657  1.000 11.200 0 315 LYS A C     1 ? 
ATOM   2526 O  O     . LYS A 1 315 ? 15.692  10.847  16.499  1.000 10.647 0 315 LYS A O     1 ? 
ATOM   2527 C  CB    . LYS A 1 315 ? 16.632  13.344  18.553  1.000 14.260 0 315 LYS A CB    1 ? 
ATOM   2528 C  CG    . LYS A 1 315 ? 17.961  13.044  17.863  1.000 16.866 0 315 LYS A CG    1 ? 
ATOM   2529 C  CD    . LYS A 1 315 ? 19.133  13.691  18.638  1.000 21.438 0 315 LYS A CD    1 ? 
ATOM   2530 C  CE    . LYS A 1 315 ? 20.501  13.201  18.216  1.000 22.759 0 315 LYS A CE    1 ? 
ATOM   2531 N  NZ    . LYS A 1 315 ? 20.790  13.565  16.832  1.000 26.365 0 315 LYS A NZ    1 ? 
ATOM   2532 N  N     . ALA A 1 316 ? 15.159  10.536  18.677  1.000 11.967 0 316 ALA A N     1 ? 
ATOM   2533 C  CA    . ALA A 1 316 ? 15.161  9.052   18.621  1.000 11.833 0 316 ALA A CA    1 ? 
ATOM   2534 C  C     . ALA A 1 316 ? 14.200  8.639   17.524  1.000 11.143 0 316 ALA A C     1 ? 
ATOM   2535 O  O     . ALA A 1 316 ? 14.482  7.668   16.821  1.000 12.174 0 316 ALA A O     1 ? 
ATOM   2536 C  CB    . ALA A 1 316 ? 14.830  8.407   19.923  1.000 12.788 0 316 ALA A CB    1 ? 
ATOM   2537 N  N     . LEU A 1 317 ? 13.051  9.294   17.425  1.000 9.446  0 317 LEU A N     1 ? 
ATOM   2538 C  CA    . LEU A 1 317 ? 12.028  8.928   16.436  1.000 8.921  0 317 LEU A CA    1 ? 
ATOM   2539 C  C     . LEU A 1 317 ? 12.452  9.400   15.059  1.000 7.437  0 317 LEU A C     1 ? 
ATOM   2540 O  O     . LEU A 1 317 ? 12.201  8.664   14.064  1.000 6.818  0 317 LEU A O     1 ? 
ATOM   2541 C  CB    . LEU A 1 317 ? 10.680  9.478   16.869  1.000 8.808  0 317 LEU A CB    1 ? 
ATOM   2542 C  CG    . LEU A 1 317 ? 10.148  8.894   18.156  1.000 9.565  0 317 LEU A CG    1 ? 
ATOM   2543 C  CD1   . LEU A 1 317 ? 8.873   9.602   18.588  1.000 11.798 0 317 LEU A CD1   1 ? 
ATOM   2544 C  CD2   . LEU A 1 317 ? 9.934   7.407   18.039  1.000 10.376 0 317 LEU A CD2   1 ? 
ATOM   2545 N  N     . ALA A 1 318 ? 13.018  10.619  14.911  1.000 7.416  0 318 ALA A N     1 ? 
ATOM   2546 C  CA    . ALA A 1 318 ? 13.440  11.131  13.596  1.000 8.205  0 318 ALA A CA    1 ? 
ATOM   2547 C  C     . ALA A 1 318 ? 14.545  10.240  12.990  1.000 7.765  0 318 ALA A C     1 ? 
ATOM   2548 O  O     . ALA A 1 318 ? 14.614  10.156  11.764  1.000 8.728  0 318 ALA A O     1 ? 
ATOM   2549 C  CB    . ALA A 1 318 ? 13.898  12.580  13.689  1.000 9.478  0 318 ALA A CB    1 ? 
ATOM   2550 N  N     . ASP A 1 319 ? 15.254  9.500   13.798  1.000 8.597  0 319 ASP A N     1 ? 
ATOM   2551 C  CA    . ASP A 1 319 ? 16.289  8.565   13.275  1.000 9.378  0 319 ASP A CA    1 ? 
ATOM   2552 C  C     . ASP A 1 319 ? 15.650  7.414   12.523  1.000 8.225  0 319 ASP A C     1 ? 
ATOM   2553 O  O     . ASP A 1 319 ? 16.293  6.851   11.632  1.000 8.274  0 319 ASP A O     1 ? 
ATOM   2554 C  CB    . ASP A 1 319 ? 17.125  8.037   14.410  1.000 10.607 0 319 ASP A CB    1 ? 
ATOM   2555 C  CG    . ASP A 1 319 ? 18.041  9.116   14.999  1.000 10.552 0 319 ASP A CG    1 ? 
ATOM   2556 O  OD1   . ASP A 1 319 ? 18.497  8.917   16.040  1.000 14.784 0 319 ASP A OD1   1 ? 
ATOM   2557 O  OD2   . ASP A 1 319 ? 18.278  10.123  14.311  1.000 14.961 0 319 ASP A OD2   1 ? 
ATOM   2558 N  N     . HIS A 1 320 ? 14.352  7.189   12.721  1.000 6.895  0 320 HIS A N     1 ? 
ATOM   2559 C  CA    . HIS A 1 320 ? 13.604  6.128   11.964  1.000 7.171  0 320 HIS A CA    1 ? 
ATOM   2560 C  C     . HIS A 1 320 ? 12.552  6.663   11.028  1.000 7.337  0 320 HIS A C     1 ? 
ATOM   2561 O  O     . HIS A 1 320 ? 12.285  6.021   10.032  1.000 7.337  0 320 HIS A O     1 ? 
ATOM   2562 C  CB    . HIS A 1 320 ? 12.914  5.152   12.927  1.000 6.967  0 320 HIS A CB    1 ? 
ATOM   2563 C  CG    . HIS A 1 320 ? 13.915  4.535   13.816  1.000 7.085  0 320 HIS A CG    1 ? 
ATOM   2564 N  ND1   . HIS A 1 320 ? 14.536  3.363   13.480  1.000 7.533  0 320 HIS A ND1   1 ? 
ATOM   2565 C  CD2   . HIS A 1 320 ? 14.548  5.022   14.901  1.000 7.508  0 320 HIS A CD2   1 ? 
ATOM   2566 C  CE1   . HIS A 1 320 ? 15.499  3.151   14.391  1.000 7.522  0 320 HIS A CE1   1 ? 
ATOM   2567 N  NE2   . HIS A 1 320 ? 15.521  4.136   15.263  1.000 8.350  0 320 HIS A NE2   1 ? 
ATOM   2568 N  N     . PHE A 1 321 ? 12.013  7.848   11.260  1.000 6.979  0 321 PHE A N     1 ? 
ATOM   2569 C  CA    . PHE A 1 321 ? 10.949  8.447   10.418  1.000 8.185  0 321 PHE A CA    1 ? 
ATOM   2570 C  C     . PHE A 1 321 ? 11.476  9.504   9.474   1.000 8.730  0 321 PHE A C     1 ? 
ATOM   2571 O  O     . PHE A 1 321 ? 10.744  9.849   8.533   1.000 9.172  0 321 PHE A O     1 ? 
ATOM   2572 C  CB    . PHE A 1 321 ? 9.853   9.036   11.277  1.000 7.505  0 321 PHE A CB    1 ? 
ATOM   2573 C  CG    . PHE A 1 321 ? 9.038   7.995   11.994  1.000 7.567  0 321 PHE A CG    1 ? 
ATOM   2574 C  CD1   . PHE A 1 321 ? 8.264   7.116   11.269  1.000 8.439  0 321 PHE A CD1   1 ? 
ATOM   2575 C  CD2   . PHE A 1 321 ? 8.975   7.963   13.356  1.000 9.224  0 321 PHE A CD2   1 ? 
ATOM   2576 C  CE1   . PHE A 1 321 ? 7.511   6.148   11.894  1.000 8.421  0 321 PHE A CE1   1 ? 
ATOM   2577 C  CE2   . PHE A 1 321 ? 8.229   6.988   13.992  1.000 10.192 0 321 PHE A CE2   1 ? 
ATOM   2578 C  CZ    . PHE A 1 321 ? 7.467   6.102   13.260  1.000 8.729  0 321 PHE A CZ    1 ? 
ATOM   2579 N  N     . GLY A 1 322 ? 12.692  9.967   9.653   1.000 8.575  0 322 GLY A N     1 ? 
ATOM   2580 C  CA    . GLY A 1 322 ? 13.354  10.910  8.739   1.000 9.461  0 322 GLY A CA    1 ? 
ATOM   2581 C  C     . GLY A 1 322 ? 13.165  12.380  9.102   1.000 9.740  0 322 GLY A C     1 ? 
ATOM   2582 O  O     . GLY A 1 322 ? 12.686  12.689  10.194  1.000 8.999  0 322 GLY A O     1 ? 
ATOM   2583 N  N     . SER A 1 323 ? 13.620  13.216  8.208   1.000 10.909 0 323 SER A N     1 ? 
ATOM   2584 C  CA    . SER A 1 323 ? 13.862  14.656  8.461   1.000 12.022 0 323 SER A CA    1 ? 
ATOM   2585 C  C     . SER A 1 323 ? 12.570  15.425  8.671   1.000 11.750 0 323 SER A C     1 ? 
ATOM   2586 O  O     . SER A 1 323 ? 12.670  16.573  9.073   1.000 12.135 0 323 SER A O     1 ? 
ATOM   2587 C  CB    . SER A 1 323 ? 14.644  15.253  7.280   1.000 13.021 0 323 SER A CB    1 ? 
ATOM   2588 O  OG    . SER A 1 323 ? 13.858  15.152  6.111   1.000 19.347 0 323 SER A OG    1 ? 
ATOM   2589 N  N     . GLU A 1 324 ? 11.396  14.860  8.385   1.000 9.187  0 324 GLU A N     1 ? 
ATOM   2590 C  CA    . GLU A 1 324 ? 10.111  15.588  8.559   1.000 8.336  0 324 GLU A CA    1 ? 
ATOM   2591 C  C     . GLU A 1 324 ? 9.510   15.276  9.903   1.000 8.501  0 324 GLU A C     1 ? 
ATOM   2592 O  O     . GLU A 1 324 ? 8.495   15.845  10.229  1.000 8.969  0 324 GLU A O     1 ? 
ATOM   2593 C  CB    . GLU A 1 324 ? 9.137   15.332  7.413   1.000 8.888  0 324 GLU A CB    1 ? 
ATOM   2594 C  CG    . GLU A 1 324 ? 9.658   15.820  6.080   1.000 9.520  0 324 GLU A CG    1 ? 
ATOM   2595 C  CD    . GLU A 1 324 ? 8.630   15.980  5.006   1.000 11.148 0 324 GLU A CD    1 ? 
ATOM   2596 O  OE1   . GLU A 1 324 ? 7.758   15.110  4.920   1.000 10.269 0 324 GLU A OE1   1 ? 
ATOM   2597 O  OE2   . GLU A 1 324 ? 8.735   16.926  4.203   1.000 11.899 0 324 GLU A OE2   1 ? 
ATOM   2598 N  N     . PHE A 1 325 ? 10.085  14.379  10.686  1.000 7.491  0 325 PHE A N     1 ? 
ATOM   2599 C  CA    . PHE A 1 325 ? 9.652   14.196  12.071  1.000 7.369  0 325 PHE A CA    1 ? 
ATOM   2600 C  C     . PHE A 1 325 ? 10.123  15.369  12.910  1.000 8.466  0 325 PHE A C     1 ? 
ATOM   2601 O  O     . PHE A 1 325 ? 11.287  15.652  12.932  1.000 10.063 0 325 PHE A O     1 ? 
ATOM   2602 C  CB    . PHE A 1 325 ? 10.108  12.861  12.648  1.000 7.438  0 325 PHE A CB    1 ? 
ATOM   2603 C  CG    . PHE A 1 325 ? 9.335   12.534  13.873  1.000 7.327  0 325 PHE A CG    1 ? 
ATOM   2604 C  CD1   . PHE A 1 325 ? 9.660   13.104  15.090  1.000 7.626  0 325 PHE A CD1   1 ? 
ATOM   2605 C  CD2   . PHE A 1 325 ? 8.201   11.746  13.815  1.000 7.710  0 325 PHE A CD2   1 ? 
ATOM   2606 C  CE1   . PHE A 1 325 ? 8.882   12.909  16.218  1.000 9.250  0 325 PHE A CE1   1 ? 
ATOM   2607 C  CE2   . PHE A 1 325 ? 7.405   11.571  14.929  1.000 8.626  0 325 PHE A CE2   1 ? 
ATOM   2608 C  CZ    . PHE A 1 325 ? 7.759   12.102  16.133  1.000 9.478  0 325 PHE A CZ    1 ? 
ATOM   2609 N  N     . PRO A 1 326 ? 9.216   16.130  13.534  1.000 9.259  0 326 PRO A N     1 ? 
ATOM   2610 C  CA    . PRO A 1 326 ? 9.628   17.363  14.206  1.000 9.874  0 326 PRO A CA    1 ? 
ATOM   2611 C  C     . PRO A 1 326 ? 10.498  17.056  15.414  1.000 11.645 0 326 PRO A C     1 ? 
ATOM   2612 O  O     . PRO A 1 326 ? 10.169  16.237  16.201  1.000 11.799 0 326 PRO A O     1 ? 
ATOM   2613 C  CB    . PRO A 1 326 ? 8.349   18.083  14.595  1.000 11.830 0 326 PRO A CB    1 ? 
ATOM   2614 C  CG    . PRO A 1 326 ? 7.240   17.176  14.264  1.000 11.659 0 326 PRO A CG    1 ? 
ATOM   2615 C  CD    . PRO A 1 326 ? 7.777   15.920  13.580  1.000 9.831  0 326 PRO A CD    1 ? 
ATOM   2616 N  N     . VAL A 1 327 ? 11.606  17.790  15.562  1.000 12.014 0 327 VAL A N     1 ? 
ATOM   2617 C  CA    . VAL A 1 327 ? 12.499  17.656  16.713  1.000 12.865 0 327 VAL A CA    1 ? 
ATOM   2618 C  C     . VAL A 1 327 ? 12.612  19.014  17.366  1.000 15.100 0 327 VAL A C     1 ? 
ATOM   2619 O  O     . VAL A 1 327 ? 13.336  19.886  16.857  1.000 16.766 0 327 VAL A O     1 ? 
ATOM   2620 C  CB    . VAL A 1 327 ? 13.870  17.116  16.328  1.000 13.535 0 327 VAL A CB    1 ? 
ATOM   2621 C  CG1   . VAL A 1 327 ? 14.758  16.979  17.540  1.000 16.723 0 327 VAL A CG1   1 ? 
ATOM   2622 C  CG2   . VAL A 1 327 ? 13.738  15.796  15.564  1.000 14.274 0 327 VAL A CG2   1 ? 
ATOM   2623 N  N     . PRO A 1 328 ? 11.880  19.265  18.468  1.000 16.842 0 328 PRO A N     1 ? 
ATOM   2624 C  CA    . PRO A 1 328 ? 12.033  20.550  19.158  1.000 18.853 0 328 PRO A CA    1 ? 
ATOM   2625 C  C     . PRO A 1 328 ? 13.477  20.747  19.635  1.000 19.975 0 328 PRO A C     1 ? 
ATOM   2626 O  O     . PRO A 1 328 ? 14.065  19.817  20.149  1.000 21.741 0 328 PRO A O     1 ? 
ATOM   2627 C  CB    . PRO A 1 328 ? 11.045  20.435  20.312  1.000 17.543 0 328 PRO A CB    1 ? 
ATOM   2628 C  CG    . PRO A 1 328 ? 9.997   19.438  19.812  1.000 19.488 0 328 PRO A CG    1 ? 
ATOM   2629 C  CD    . PRO A 1 328 ? 10.795  18.427  19.014  1.000 16.778 0 328 PRO A CD    1 ? 
ATOM   2630 N  N     . GLU A 1 329 ? 13.974  21.981  19.553  1.000 30.965 0 329 GLU A N     1 ? 
ATOM   2631 C  CA    . GLU A 1 329 ? 15.290  22.394  20.118  1.000 34.351 0 329 GLU A CA    1 ? 
ATOM   2632 C  C     . GLU A 1 329 ? 15.295  22.190  21.640  1.000 33.583 0 329 GLU A C     1 ? 
ATOM   2633 O  O     . GLU A 1 329 ? 14.267  22.466  22.276  1.000 35.950 0 329 GLU A O     1 ? 
ATOM   2634 C  CB    . GLU A 1 329 ? 15.557  23.855  19.759  1.000 41.646 0 329 GLU A CB    1 ? 
ATOM   2635 C  CG    . GLU A 1 329 ? 15.845  24.066  18.284  1.000 47.967 0 329 GLU A CG    1 ? 
ATOM   2636 C  CD    . GLU A 1 329 ? 15.491  25.451  17.761  1.000 57.253 0 329 GLU A CD    1 ? 
ATOM   2637 O  OE1   . GLU A 1 329 ? 16.129  26.434  18.207  1.000 60.515 0 329 GLU A OE1   1 ? 
ATOM   2638 O  OE2   . GLU A 1 329 ? 14.565  25.548  16.923  1.000 62.426 0 329 GLU A OE2   1 ? 
ATOM   2639 N  N     . LYS A 1 330 ? 16.416  21.724  22.198  1.000 39.100 0 330 LYS A N     1 ? 
ATOM   2640 C  CA    . LYS A 1 330 ? 16.662  21.681  23.670  1.000 47.867 0 330 LYS A CA    1 ? 
ATOM   2641 C  C     . LYS A 1 330 ? 17.164  23.057  24.133  1.000 48.034 0 330 LYS A C     1 ? 
ATOM   2642 O  O     . LYS A 1 330 ? 17.333  23.967  23.318  1.000 46.289 0 330 LYS A O     1 ? 
ATOM   2643 C  CB    . LYS A 1 330 ? 17.665  20.575  24.021  1.000 52.757 0 330 LYS A CB    1 ? 
ATOM   2644 C  CG    . LYS A 1 330 ? 17.766  20.237  25.504  1.000 59.200 0 330 LYS A CG    1 ? 
ATOM   2645 C  CD    . LYS A 1 330 ? 18.714  21.147  26.267  1.000 65.898 0 330 LYS A CD    1 ? 
ATOM   2646 C  CE    . LYS A 1 330 ? 18.774  20.851  27.752  1.000 67.877 0 330 LYS A CE    1 ? 
ATOM   2647 N  NZ    . LYS A 1 330 ? 19.604  21.846  28.472  1.000 69.028 0 330 LYS A NZ    1 ? 
HETATM 2648 N  N1    . CTP B 2 .   ? -5.237  -5.316  -4.244  1.000 30.276 0 401 CTP A N1    1 ? 
HETATM 2649 C  C2    . CTP B 2 .   ? -6.289  -4.755  -3.496  1.000 31.074 0 401 CTP A C2    1 ? 
HETATM 2650 N  N3    . CTP B 2 .   ? -7.151  -5.593  -2.865  1.000 29.540 0 401 CTP A N3    1 ? 
HETATM 2651 C  C4    . CTP B 2 .   ? -7.056  -6.911  -3.015  1.000 28.897 0 401 CTP A C4    1 ? 
HETATM 2652 C  C5    . CTP B 2 .   ? -6.021  -7.498  -3.798  1.000 27.367 0 401 CTP A C5    1 ? 
HETATM 2653 C  C6    . CTP B 2 .   ? -5.137  -6.679  -4.379  1.000 28.244 0 401 CTP A C6    1 ? 
HETATM 2654 O  O2    . CTP B 2 .   ? -6.366  -3.514  -3.365  1.000 29.702 0 401 CTP A O2    1 ? 
HETATM 2655 N  N4    . CTP B 2 .   ? -7.954  -7.665  -2.400  1.000 29.412 0 401 CTP A N4    1 ? 
HETATM 2656 C  "C1'" . CTP B 2 .   ? -4.322  -4.427  -5.017  1.000 30.137 0 401 CTP A "C1'" 1 ? 
HETATM 2657 C  "C2'" . CTP B 2 .   ? -5.089  -3.403  -5.886  1.000 34.230 0 401 CTP A "C2'" 1 ? 
HETATM 2658 O  "O2'" . CTP B 2 .   ? -4.875  -3.746  -7.250  1.000 32.444 0 401 CTP A "O2'" 1 ? 
HETATM 2659 C  "C3'" . CTP B 2 .   ? -4.484  -2.047  -5.438  1.000 33.158 0 401 CTP A "C3'" 1 ? 
HETATM 2660 C  "C4'" . CTP B 2 .   ? -3.142  -2.490  -4.878  1.000 31.469 0 401 CTP A "C4'" 1 ? 
HETATM 2661 O  "O4'" . CTP B 2 .   ? -3.478  -3.700  -4.167  1.000 32.553 0 401 CTP A "O4'" 1 ? 
HETATM 2662 O  "O3'" . CTP B 2 .   ? -4.268  -1.077  -6.457  1.000 32.443 0 401 CTP A "O3'" 1 ? 
HETATM 2663 C  "C5'" . CTP B 2 .   ? -2.457  -1.526  -3.969  1.000 26.039 0 401 CTP A "C5'" 1 ? 
HETATM 2664 O  "O5'" . CTP B 2 .   ? -1.252  -2.134  -3.493  1.000 25.301 0 401 CTP A "O5'" 1 ? 
HETATM 2665 P  PA    . CTP B 2 .   ? -0.155  -1.091  -2.947  1.000 21.611 0 401 CTP A PA    1 ? 
HETATM 2666 O  O1A   . CTP B 2 .   ? 1.049   -1.848  -2.420  1.000 19.239 0 401 CTP A O1A   1 ? 
HETATM 2667 O  O2A   . CTP B 2 .   ? 0.018   0.002   -3.962  1.000 20.412 0 401 CTP A O2A   1 ? 
HETATM 2668 O  O3A   . CTP B 2 .   ? -0.890  -0.591  -1.644  1.000 18.347 0 401 CTP A O3A   1 ? 
HETATM 2669 P  PB    . CTP B 2 .   ? -1.318  0.837   -1.213  1.000 14.787 0 401 CTP A PB    1 ? 
HETATM 2670 O  O1B   . CTP B 2 .   ? -2.331  0.595   -0.130  1.000 16.467 0 401 CTP A O1B   1 ? 
HETATM 2671 O  O2B   . CTP B 2 .   ? -1.738  1.686   -2.439  1.000 13.053 0 401 CTP A O2B   1 ? 
HETATM 2672 O  O3B   . CTP B 2 .   ? 0.060   1.373   -0.545  1.000 14.201 0 401 CTP A O3B   1 ? 
HETATM 2673 P  PG    . CTP B 2 .   ? 1.066   2.593   -0.963  1.000 13.225 0 401 CTP A PG    1 ? 
HETATM 2674 O  O1G   . CTP B 2 .   ? 1.090   2.545   -2.492  1.000 14.282 0 401 CTP A O1G   1 ? 
HETATM 2675 O  O2G   . CTP B 2 .   ? 2.339   2.197   -0.313  1.000 14.711 0 401 CTP A O2G   1 ? 
HETATM 2676 O  O3G   . CTP B 2 .   ? 0.418   3.777   -0.399  1.000 13.344 0 401 CTP A O3G   1 ? 
HETATM 2677 MN MN    . MN  C 3 .   ? 0.644   0.814   -7.256  1.000 16.611 0 402 MN  A MN    1 ? 
HETATM 2678 MN MN    . MN  D 3 .   ? -0.454  2.237   -3.989  1.000 15.330 0 403 MN  A MN    1 ? 
HETATM 2679 P  P     . PO4 E 4 .   ? -5.111  14.036  19.935  1.000 19.567 0 404 PO4 A P     1 ? 
HETATM 2680 O  O1    . PO4 E 4 .   ? -4.166  13.607  18.823  1.000 15.427 0 404 PO4 A O1    1 ? 
HETATM 2681 O  O2    . PO4 E 4 .   ? -6.479  13.429  19.686  1.000 25.938 0 404 PO4 A O2    1 ? 
HETATM 2682 O  O3    . PO4 E 4 .   ? -5.224  15.604  19.883  1.000 30.478 0 404 PO4 A O3    1 ? 
HETATM 2683 O  O4    . PO4 E 4 .   ? -4.645  13.638  21.276  1.000 24.319 0 404 PO4 A O4    1 ? 
HETATM 2684 O  O     . HOH F 5 .   ? -4.055  -5.763  -7.720  1.000 39.778 0 501 HOH A O     1 ? 
HETATM 2685 O  O     . HOH F 5 .   ? -10.907 11.759  -25.852 1.000 39.084 0 502 HOH A O     1 ? 
HETATM 2686 O  O     . HOH F 5 .   ? -18.322 -14.563 -25.036 1.000 32.464 0 503 HOH A O     1 ? 
HETATM 2687 O  O     . HOH F 5 .   ? -6.482  13.049  31.961  1.000 36.001 0 504 HOH A O     1 ? 
HETATM 2688 O  O     . HOH F 5 .   ? -12.904 2.835   -1.430  1.000 26.013 0 505 HOH A O     1 ? 
HETATM 2689 O  O     . HOH F 5 .   ? 3.758   -4.167  23.645  1.000 33.940 0 506 HOH A O     1 ? 
HETATM 2690 O  O     . HOH F 5 .   ? 19.689  12.488  14.941  1.000 30.391 0 507 HOH A O     1 ? 
HETATM 2691 O  O     . HOH F 5 .   ? 17.303  -5.891  -4.586  1.000 29.296 0 508 HOH A O     1 ? 
HETATM 2692 O  O     . HOH F 5 .   ? 5.160   -9.789  -1.650  1.000 24.389 0 509 HOH A O     1 ? 
HETATM 2693 O  O     . HOH F 5 .   ? 16.331  13.243  27.606  1.000 33.816 0 510 HOH A O     1 ? 
HETATM 2694 O  O     . HOH F 5 .   ? -0.414  16.969  -12.784 1.000 41.406 0 511 HOH A O     1 ? 
HETATM 2695 O  O     . HOH F 5 .   ? -1.766  11.053  -16.128 1.000 33.104 0 512 HOH A O     1 ? 
HETATM 2696 O  O     . HOH F 5 .   ? -7.771  -1.481  -3.783  1.000 18.578 0 513 HOH A O     1 ? 
HETATM 2697 O  O     . HOH F 5 .   ? -17.819 -3.903  -24.724 1.000 36.263 0 514 HOH A O     1 ? 
HETATM 2698 O  O     . HOH F 5 .   ? -3.118  17.728  -5.236  1.000 31.601 0 515 HOH A O     1 ? 
HETATM 2699 O  O     . HOH F 5 .   ? 8.895   -3.560  -2.263  1.000 28.615 0 516 HOH A O     1 ? 
HETATM 2700 O  O     . HOH F 5 .   ? -15.854 0.839   -27.790 1.000 40.771 0 517 HOH A O     1 ? 
HETATM 2701 O  O     . HOH F 5 .   ? 21.638  -21.280 -1.798  1.000 33.503 0 518 HOH A O     1 ? 
HETATM 2702 O  O     . HOH F 5 .   ? -2.717  1.606   2.182   1.000 13.004 0 519 HOH A O     1 ? 
HETATM 2703 O  O     . HOH F 5 .   ? -16.751 2.305   15.852  1.000 22.060 0 520 HOH A O     1 ? 
HETATM 2704 O  O     . HOH F 5 .   ? 10.508  -22.786 12.905  1.000 26.125 0 521 HOH A O     1 ? 
HETATM 2705 O  O     . HOH F 5 .   ? 9.316   10.403  -11.801 1.000 42.509 0 522 HOH A O     1 ? 
HETATM 2706 O  O     . HOH F 5 .   ? -16.618 -7.489  -3.231  1.000 31.613 0 523 HOH A O     1 ? 
HETATM 2707 O  O     . HOH F 5 .   ? 2.404   6.260   26.438  1.000 17.973 0 524 HOH A O     1 ? 
HETATM 2708 O  O     . HOH F 5 .   ? 9.319   -12.887 16.497  1.000 33.756 0 525 HOH A O     1 ? 
HETATM 2709 O  O     . HOH F 5 .   ? -0.733  5.310   -26.769 1.000 45.690 0 526 HOH A O     1 ? 
HETATM 2710 O  O     . HOH F 5 .   ? -11.046 -10.916 8.813   1.000 16.057 0 527 HOH A O     1 ? 
HETATM 2711 O  O     . HOH F 5 .   ? 7.548   3.799   -1.601  1.000 30.529 0 528 HOH A O     1 ? 
HETATM 2712 O  O     . HOH F 5 .   ? 20.744  9.989   16.776  1.000 16.456 0 529 HOH A O     1 ? 
HETATM 2713 O  O     . HOH F 5 .   ? -1.191  4.356   -3.942  1.000 15.953 0 530 HOH A O     1 ? 
HETATM 2714 O  O     . HOH F 5 .   ? 19.040  6.420   16.510  1.000 17.617 0 531 HOH A O     1 ? 
HETATM 2715 O  O     . HOH F 5 .   ? -9.317  -17.415 -20.431 1.000 32.760 0 532 HOH A O     1 ? 
HETATM 2716 O  O     . HOH F 5 .   ? 7.886   -4.597  23.716  1.000 30.763 0 533 HOH A O     1 ? 
HETATM 2717 O  O     . HOH F 5 .   ? -5.427  -8.154  -31.806 1.000 48.631 0 534 HOH A O     1 ? 
HETATM 2718 O  O     . HOH F 5 .   ? 3.967   -17.146 2.058   1.000 25.978 0 535 HOH A O     1 ? 
HETATM 2719 O  O     . HOH F 5 .   ? -8.629  15.124  34.897  1.000 33.647 0 536 HOH A O     1 ? 
HETATM 2720 O  O     . HOH F 5 .   ? 3.910   2.294   25.677  1.000 17.318 0 537 HOH A O     1 ? 
HETATM 2721 O  O     . HOH F 5 .   ? -14.351 -10.590 -5.941  1.000 25.762 0 538 HOH A O     1 ? 
HETATM 2722 O  O     . HOH F 5 .   ? 2.170   7.987   -2.443  1.000 16.497 0 539 HOH A O     1 ? 
HETATM 2723 O  O     . HOH F 5 .   ? 13.401  -23.022 11.381  1.000 15.661 0 540 HOH A O     1 ? 
HETATM 2724 O  O     . HOH F 5 .   ? -4.974  18.833  -12.434 1.000 37.226 0 541 HOH A O     1 ? 
HETATM 2725 O  O     . HOH F 5 .   ? -2.690  12.776  23.595  1.000 20.768 0 542 HOH A O     1 ? 
HETATM 2726 O  O     . HOH F 5 .   ? 22.069  -13.401 7.779   1.000 13.891 0 543 HOH A O     1 ? 
HETATM 2727 O  O     . HOH F 5 .   ? 2.951   22.034  9.170   1.000 15.244 0 544 HOH A O     1 ? 
HETATM 2728 O  O     . HOH F 5 .   ? 6.040   -13.879 3.968   1.000 12.973 0 545 HOH A O     1 ? 
HETATM 2729 O  O     . HOH F 5 .   ? -15.957 -4.966  -6.898  1.000 32.867 0 546 HOH A O     1 ? 
HETATM 2730 O  O     . HOH F 5 .   ? 20.488  16.005  24.096  1.000 29.883 0 547 HOH A O     1 ? 
HETATM 2731 O  O     . HOH F 5 .   ? -18.164 -1.428  -19.784 1.000 37.233 0 548 HOH A O     1 ? 
HETATM 2732 O  O     . HOH F 5 .   ? 3.299   8.411   24.220  1.000 13.375 0 549 HOH A O     1 ? 
HETATM 2733 O  O     . HOH F 5 .   ? -7.079  -9.795  14.087  1.000 29.635 0 550 HOH A O     1 ? 
HETATM 2734 O  O     . HOH F 5 .   ? 3.570   2.145   -3.296  1.000 29.618 0 551 HOH A O     1 ? 
HETATM 2735 O  O     . HOH F 5 .   ? -4.318  -18.184 2.265   1.000 41.794 0 552 HOH A O     1 ? 
HETATM 2736 O  O     . HOH F 5 .   ? 5.929   14.913  3.028   1.000 8.915  0 553 HOH A O     1 ? 
HETATM 2737 O  O     . HOH F 5 .   ? 5.337   15.842  -3.104  1.000 31.208 0 554 HOH A O     1 ? 
HETATM 2738 O  O     . HOH F 5 .   ? 1.114   6.323   -0.327  1.000 16.112 0 555 HOH A O     1 ? 
HETATM 2739 O  O     . HOH F 5 .   ? 6.803   8.865   2.073   1.000 11.490 0 556 HOH A O     1 ? 
HETATM 2740 O  O     . HOH F 5 .   ? -11.745 12.043  19.982  1.000 19.548 0 557 HOH A O     1 ? 
HETATM 2741 O  O     . HOH F 5 .   ? 0.064   20.844  11.566  1.000 22.532 0 558 HOH A O     1 ? 
HETATM 2742 O  O     . HOH F 5 .   ? 1.454   -10.457 20.128  1.000 31.657 0 559 HOH A O     1 ? 
HETATM 2743 O  O     . HOH F 5 .   ? -6.907  -6.239  -7.104  1.000 24.345 0 560 HOH A O     1 ? 
HETATM 2744 O  O     . HOH F 5 .   ? -3.021  15.720  29.931  1.000 33.991 0 561 HOH A O     1 ? 
HETATM 2745 O  O     . HOH F 5 .   ? -1.545  6.842   26.914  1.000 25.574 0 562 HOH A O     1 ? 
HETATM 2746 O  O     . HOH F 5 .   ? 4.921   16.743  23.005  1.000 16.872 0 563 HOH A O     1 ? 
HETATM 2747 O  O     . HOH F 5 .   ? 13.657  -5.638  3.893   1.000 12.018 0 564 HOH A O     1 ? 
HETATM 2748 O  O     . HOH F 5 .   ? -16.059 -8.989  0.144   1.000 21.168 0 565 HOH A O     1 ? 
HETATM 2749 O  O     . HOH F 5 .   ? 10.952  -13.112 -4.708  1.000 32.439 0 566 HOH A O     1 ? 
HETATM 2750 O  O     . HOH F 5 .   ? 19.547  -7.457  13.742  1.000 33.721 0 567 HOH A O     1 ? 
HETATM 2751 O  O     . HOH F 5 .   ? 4.739   5.837   -0.506  1.000 39.160 0 568 HOH A O     1 ? 
HETATM 2752 O  O     . HOH F 5 .   ? 0.560   16.843  3.878   1.000 11.121 0 569 HOH A O     1 ? 
HETATM 2753 O  O     . HOH F 5 .   ? -19.711 -3.857  3.853   1.000 15.448 0 570 HOH A O     1 ? 
HETATM 2754 O  O     . HOH F 5 .   ? 5.882   5.123   -5.755  1.000 42.393 0 571 HOH A O     1 ? 
HETATM 2755 O  O     . HOH F 5 .   ? 17.564  -22.823 11.889  1.000 28.437 0 572 HOH A O     1 ? 
HETATM 2756 O  O     . HOH F 5 .   ? -5.565  -9.675  -6.436  1.000 39.014 0 573 HOH A O     1 ? 
HETATM 2757 O  O     . HOH F 5 .   ? -12.534 11.246  12.754  1.000 34.733 0 574 HOH A O     1 ? 
HETATM 2758 O  O     . HOH F 5 .   ? 11.832  -27.802 3.497   1.000 14.851 0 575 HOH A O     1 ? 
HETATM 2759 O  O     . HOH F 5 .   ? 18.233  1.654   5.910   1.000 15.447 0 576 HOH A O     1 ? 
HETATM 2760 O  O     . HOH F 5 .   ? -5.494  11.899  -21.829 1.000 33.455 0 577 HOH A O     1 ? 
HETATM 2761 O  O     . HOH F 5 .   ? 12.594  5.005   -0.558  1.000 25.663 0 578 HOH A O     1 ? 
HETATM 2762 O  O     . HOH F 5 .   ? 17.909  -14.282 11.436  1.000 21.884 0 579 HOH A O     1 ? 
HETATM 2763 O  O     . HOH F 5 .   ? -1.703  -0.672  18.239  1.000 9.142  0 580 HOH A O     1 ? 
HETATM 2764 O  O     . HOH F 5 .   ? -8.146  6.770   -31.065 1.000 37.670 0 581 HOH A O     1 ? 
HETATM 2765 O  O     . HOH F 5 .   ? -18.141 -3.479  -33.035 1.000 37.570 0 582 HOH A O     1 ? 
HETATM 2766 O  O     . HOH F 5 .   ? 1.702   -15.670 13.084  1.000 32.365 0 583 HOH A O     1 ? 
HETATM 2767 O  O     . HOH F 5 .   ? 14.547  18.508  9.182   1.000 30.564 0 584 HOH A O     1 ? 
HETATM 2768 O  O     . HOH F 5 .   ? -7.539  14.906  -16.782 1.000 35.028 0 585 HOH A O     1 ? 
HETATM 2769 O  O     . HOH F 5 .   ? 12.257  14.812  3.957   1.000 29.814 0 586 HOH A O     1 ? 
HETATM 2770 O  O     . HOH F 5 .   ? 14.780  11.740  -0.876  1.000 32.676 0 587 HOH A O     1 ? 
HETATM 2771 O  O     . HOH F 5 .   ? 18.853  7.389   10.929  1.000 12.343 0 588 HOH A O     1 ? 
HETATM 2772 O  O     . HOH F 5 .   ? 3.841   -14.924 10.096  1.000 17.095 0 589 HOH A O     1 ? 
HETATM 2773 O  O     . HOH F 5 .   ? -7.677  12.700  2.498   1.000 13.813 0 590 HOH A O     1 ? 
HETATM 2774 O  O     . HOH F 5 .   ? 2.668   15.454  25.764  1.000 27.715 0 591 HOH A O     1 ? 
HETATM 2775 O  O     . HOH F 5 .   ? -13.304 -11.867 -0.929  1.000 18.132 0 592 HOH A O     1 ? 
HETATM 2776 O  O     . HOH F 5 .   ? -13.336 4.808   8.011   1.000 19.186 0 593 HOH A O     1 ? 
HETATM 2777 O  O     . HOH F 5 .   ? 9.236   11.148  26.556  1.000 25.259 0 594 HOH A O     1 ? 
HETATM 2778 O  O     . HOH F 5 .   ? -8.676  16.107  24.010  1.000 38.648 0 595 HOH A O     1 ? 
HETATM 2779 O  O     . HOH F 5 .   ? 13.778  -20.872 16.031  1.000 34.007 0 596 HOH A O     1 ? 
HETATM 2780 O  O     . HOH F 5 .   ? 21.708  -23.536 9.228   1.000 33.978 0 597 HOH A O     1 ? 
HETATM 2781 O  O     . HOH F 5 .   ? 14.050  1.266   11.795  1.000 6.963  0 598 HOH A O     1 ? 
HETATM 2782 O  O     . HOH F 5 .   ? -4.160  10.038  -1.859  1.000 15.346 0 599 HOH A O     1 ? 
HETATM 2783 O  O     . HOH F 5 .   ? 11.561  -4.380  23.775  1.000 34.423 0 600 HOH A O     1 ? 
HETATM 2784 O  O     . HOH F 5 .   ? 17.554  -4.253  15.350  1.000 23.794 0 601 HOH A O     1 ? 
HETATM 2785 O  O     . HOH F 5 .   ? -9.093  13.528  20.515  1.000 26.022 0 602 HOH A O     1 ? 
HETATM 2786 O  O     . HOH F 5 .   ? -7.433  -0.624  22.401  1.000 24.533 0 603 HOH A O     1 ? 
HETATM 2787 O  O     . HOH F 5 .   ? -1.391  18.501  14.057  1.000 20.023 0 604 HOH A O     1 ? 
HETATM 2788 O  O     . HOH F 5 .   ? 1.036   16.632  -3.090  1.000 34.184 0 605 HOH A O     1 ? 
HETATM 2789 O  O     . HOH F 5 .   ? 6.664   -9.861  22.760  1.000 39.805 0 606 HOH A O     1 ? 
HETATM 2790 O  O     . HOH F 5 .   ? 13.870  15.685  11.981  1.000 19.204 0 607 HOH A O     1 ? 
HETATM 2791 O  O     . HOH F 5 .   ? 2.164   9.935   20.929  1.000 10.551 0 608 HOH A O     1 ? 
HETATM 2792 O  O     . HOH F 5 .   ? -3.380  -10.109 -3.951  1.000 24.418 0 609 HOH A O     1 ? 
HETATM 2793 O  O     . HOH F 5 .   ? 16.509  7.500   2.852   1.000 28.687 0 610 HOH A O     1 ? 
HETATM 2794 O  O     . HOH F 5 .   ? -11.429 1.808   9.781   1.000 8.355  0 611 HOH A O     1 ? 
HETATM 2795 O  O     . HOH F 5 .   ? -15.851 11.460  25.594  1.000 32.329 0 612 HOH A O     1 ? 
HETATM 2796 O  O     . HOH F 5 .   ? -0.390  -1.101  -7.025  1.000 30.652 0 613 HOH A O     1 ? 
HETATM 2797 O  O     . HOH F 5 .   ? 6.615   13.395  -7.612  1.000 33.846 0 614 HOH A O     1 ? 
HETATM 2798 O  O     . HOH F 5 .   ? 18.216  3.870   7.058   1.000 22.607 0 615 HOH A O     1 ? 
HETATM 2799 O  O     . HOH F 5 .   ? 18.181  0.826   2.616   1.000 32.807 0 616 HOH A O     1 ? 
HETATM 2800 O  O     . HOH F 5 .   ? -11.445 2.175   20.668  1.000 35.351 0 617 HOH A O     1 ? 
HETATM 2801 O  O     . HOH F 5 .   ? -11.034 -12.470 6.538   1.000 15.157 0 618 HOH A O     1 ? 
HETATM 2802 O  O     . HOH F 5 .   ? 16.458  -9.988  12.069  1.000 19.511 0 619 HOH A O     1 ? 
HETATM 2803 O  O     . HOH F 5 .   ? 16.644  1.915   17.840  1.000 16.444 0 620 HOH A O     1 ? 
HETATM 2804 O  O     . HOH F 5 .   ? -10.059 3.676   4.929   1.000 10.344 0 621 HOH A O     1 ? 
HETATM 2805 O  O     . HOH F 5 .   ? -20.031 -14.578 -21.146 1.000 33.736 0 622 HOH A O     1 ? 
HETATM 2806 O  O     . HOH F 5 .   ? 20.491  16.313  16.920  1.000 43.133 0 623 HOH A O     1 ? 
HETATM 2807 O  O     . HOH F 5 .   ? -1.415  -3.520  18.324  1.000 10.388 0 624 HOH A O     1 ? 
HETATM 2808 O  O     . HOH F 5 .   ? -12.433 9.483   20.494  1.000 28.509 0 625 HOH A O     1 ? 
HETATM 2809 O  O     . HOH F 5 .   ? -6.713  -5.593  15.339  1.000 14.166 0 626 HOH A O     1 ? 
HETATM 2810 O  O     . HOH F 5 .   ? 17.724  10.580  21.336  1.000 19.756 0 627 HOH A O     1 ? 
HETATM 2811 O  O     . HOH F 5 .   ? -4.284  0.383   23.761  1.000 26.531 0 628 HOH A O     1 ? 
HETATM 2812 O  O     . HOH F 5 .   ? -15.639 -1.158  14.538  1.000 23.509 0 629 HOH A O     1 ? 
HETATM 2813 O  O     . HOH F 5 .   ? 1.205   -14.151 10.685  1.000 33.162 0 630 HOH A O     1 ? 
HETATM 2814 O  O     . HOH F 5 .   ? -12.503 14.623  14.910  1.000 33.953 0 631 HOH A O     1 ? 
HETATM 2815 O  O     . HOH F 5 .   ? -4.746  9.347   0.887   1.000 14.519 0 632 HOH A O     1 ? 
HETATM 2816 O  O     . HOH F 5 .   ? -14.001 -11.262 -13.906 1.000 22.080 0 633 HOH A O     1 ? 
HETATM 2817 O  O     . HOH F 5 .   ? 23.418  -20.674 3.866   1.000 46.435 0 634 HOH A O     1 ? 
HETATM 2818 O  O     . HOH F 5 .   ? 18.870  0.370   12.454  1.000 20.625 0 635 HOH A O     1 ? 
HETATM 2819 O  O     . HOH F 5 .   ? -2.380  14.954  12.285  1.000 9.382  0 636 HOH A O     1 ? 
HETATM 2820 O  O     . HOH F 5 .   ? 11.418  -14.905 13.727  1.000 16.864 0 637 HOH A O     1 ? 
HETATM 2821 O  O     . HOH F 5 .   ? 10.515  12.159  6.999   1.000 8.590  0 638 HOH A O     1 ? 
HETATM 2822 O  O     . HOH F 5 .   ? -10.932 14.703  -12.774 1.000 33.568 0 639 HOH A O     1 ? 
HETATM 2823 O  O     . HOH F 5 .   ? 19.451  -21.088 10.344  1.000 24.921 0 640 HOH A O     1 ? 
HETATM 2824 O  O     . HOH F 5 .   ? -15.233 -6.086  -39.359 1.000 33.448 0 641 HOH A O     1 ? 
HETATM 2825 O  O     . HOH F 5 .   ? -10.908 2.155   2.676   1.000 10.992 0 642 HOH A O     1 ? 
HETATM 2826 O  O     . HOH F 5 .   ? 11.386  18.080  11.034  1.000 15.324 0 643 HOH A O     1 ? 
HETATM 2827 O  O     . HOH F 5 .   ? -10.349 -4.126  15.636  1.000 32.181 0 644 HOH A O     1 ? 
HETATM 2828 O  O     . HOH F 5 .   ? 10.896  -6.070  21.685  1.000 20.279 0 645 HOH A O     1 ? 
HETATM 2829 O  O     . HOH F 5 .   ? -4.004  -0.841  -9.385  1.000 24.053 0 646 HOH A O     1 ? 
HETATM 2830 O  O     . HOH F 5 .   ? 17.757  -11.043 -0.942  1.000 17.688 0 647 HOH A O     1 ? 
HETATM 2831 O  O     . HOH F 5 .   ? 7.803   14.626  -3.090  1.000 33.930 0 648 HOH A O     1 ? 
HETATM 2832 O  O     . HOH F 5 .   ? -4.323  7.486   -26.411 1.000 36.396 0 649 HOH A O     1 ? 
HETATM 2833 O  O     . HOH F 5 .   ? -16.555 -3.588  11.026  1.000 18.885 0 650 HOH A O     1 ? 
HETATM 2834 O  O     . HOH F 5 .   ? 6.801   -18.695 7.307   1.000 24.341 0 651 HOH A O     1 ? 
HETATM 2835 O  O     . HOH F 5 .   ? 9.717   2.854   27.491  1.000 26.494 0 652 HOH A O     1 ? 
HETATM 2836 O  O     . HOH F 5 .   ? -7.396  10.239  16.270  1.000 8.973  0 653 HOH A O     1 ? 
HETATM 2837 O  O     . HOH F 5 .   ? -15.823 -12.147 -7.370  1.000 32.929 0 654 HOH A O     1 ? 
HETATM 2838 O  O     . HOH F 5 .   ? -10.786 -10.276 -36.203 1.000 13.032 0 655 HOH A O     1 ? 
HETATM 2839 O  O     . HOH F 5 .   ? -17.780 -8.787  -32.759 1.000 37.051 0 656 HOH A O     1 ? 
HETATM 2840 O  O     . HOH F 5 .   ? 7.174   15.142  0.591   1.000 13.841 0 657 HOH A O     1 ? 
HETATM 2841 O  O     . HOH F 5 .   ? -11.117 8.997   -2.177  1.000 18.472 0 658 HOH A O     1 ? 
HETATM 2842 O  O     . HOH F 5 .   ? -3.909  -6.826  -14.000 1.000 18.704 0 659 HOH A O     1 ? 
HETATM 2843 O  O     . HOH F 5 .   ? 13.710  -8.909  16.767  1.000 23.018 0 660 HOH A O     1 ? 
HETATM 2844 O  O     . HOH F 5 .   ? 16.436  11.802  10.382  1.000 18.031 0 661 HOH A O     1 ? 
HETATM 2845 O  O     . HOH F 5 .   ? 5.534   15.122  25.070  1.000 26.498 0 662 HOH A O     1 ? 
HETATM 2846 O  O     . HOH F 5 .   ? -12.528 8.200   10.414  1.000 14.843 0 663 HOH A O     1 ? 
HETATM 2847 O  O     . HOH F 5 .   ? 7.704   -16.701 0.365   1.000 31.444 0 664 HOH A O     1 ? 
HETATM 2848 O  O     . HOH F 5 .   ? -8.395  -2.151  16.284  1.000 15.438 0 665 HOH A O     1 ? 
HETATM 2849 O  O     . HOH F 5 .   ? -3.514  -6.901  17.989  1.000 19.999 0 666 HOH A O     1 ? 
HETATM 2850 O  O     . HOH F 5 .   ? 5.815   -3.179  23.688  1.000 33.447 0 667 HOH A O     1 ? 
HETATM 2851 O  O     . HOH F 5 .   ? 11.035  -25.773 5.161   1.000 22.590 0 668 HOH A O     1 ? 
HETATM 2852 O  O     . HOH F 5 .   ? -6.968  -14.370 5.374   1.000 17.354 0 669 HOH A O     1 ? 
HETATM 2853 O  O     . HOH F 5 .   ? -12.895 9.572   3.690   1.000 28.082 0 670 HOH A O     1 ? 
HETATM 2854 O  O     . HOH F 5 .   ? -13.391 1.687   -5.345  1.000 24.283 0 671 HOH A O     1 ? 
HETATM 2855 O  O     . HOH F 5 .   ? 14.627  -16.462 0.362   1.000 26.002 0 672 HOH A O     1 ? 
HETATM 2856 O  O     . HOH F 5 .   ? -11.050 17.775  -4.571  1.000 27.444 0 673 HOH A O     1 ? 
HETATM 2857 O  O     . HOH F 5 .   ? -13.980 3.250   22.284  1.000 38.048 0 674 HOH A O     1 ? 
HETATM 2858 O  O     . HOH F 5 .   ? -12.797 1.382   -24.141 1.000 32.028 0 675 HOH A O     1 ? 
HETATM 2859 O  O     . HOH F 5 .   ? -13.374 7.788   22.397  1.000 26.031 0 676 HOH A O     1 ? 
HETATM 2860 O  O     . HOH F 5 .   ? -11.596 6.683   1.745   1.000 23.268 0 677 HOH A O     1 ? 
HETATM 2861 O  O     . HOH F 5 .   ? 5.520   -16.783 8.754   1.000 19.924 0 678 HOH A O     1 ? 
HETATM 2862 O  O     . HOH F 5 .   ? -6.199  14.841  8.105   1.000 25.621 0 679 HOH A O     1 ? 
HETATM 2863 O  O     . HOH F 5 .   ? -13.847 11.127  -9.653  1.000 43.247 0 680 HOH A O     1 ? 
HETATM 2864 O  O     . HOH F 5 .   ? 5.682   -8.489  -18.799 1.000 44.792 0 681 HOH A O     1 ? 
HETATM 2865 O  O     . HOH F 5 .   ? 2.098   21.111  15.382  1.000 24.677 0 682 HOH A O     1 ? 
HETATM 2866 O  O     . HOH F 5 .   ? -6.061  9.968   9.953   1.000 13.682 0 683 HOH A O     1 ? 
HETATM 2867 O  O     . HOH F 5 .   ? -3.998  4.604   -4.948  1.000 13.640 0 684 HOH A O     1 ? 
HETATM 2868 O  O     . HOH F 5 .   ? -13.932 -6.003  -5.526  1.000 17.665 0 685 HOH A O     1 ? 
HETATM 2869 O  O     . HOH F 5 .   ? 16.498  5.787   17.567  1.000 16.391 0 686 HOH A O     1 ? 
HETATM 2870 O  O     . HOH F 5 .   ? 9.821   -18.730 15.132  1.000 26.773 0 687 HOH A O     1 ? 
HETATM 2871 O  O     . HOH F 5 .   ? -11.234 9.881   -17.922 1.000 31.135 0 688 HOH A O     1 ? 
HETATM 2872 O  O     . HOH F 5 .   ? 10.495  -8.394  19.755  1.000 17.159 0 689 HOH A O     1 ? 
HETATM 2873 O  O     . HOH F 5 .   ? 14.371  0.857   23.904  1.000 32.474 0 690 HOH A O     1 ? 
HETATM 2874 O  O     . HOH F 5 .   ? -9.066  11.652  8.840   1.000 36.897 0 691 HOH A O     1 ? 
HETATM 2875 O  O     . HOH F 5 .   ? 3.832   0.074   -1.756  1.000 25.704 0 692 HOH A O     1 ? 
HETATM 2876 O  O     . HOH F 5 .   ? -12.446 10.063  -7.200  1.000 22.242 0 693 HOH A O     1 ? 
HETATM 2877 O  O     . HOH F 5 .   ? 0.357   18.873  16.133  1.000 14.870 0 694 HOH A O     1 ? 
HETATM 2878 O  O     . HOH F 5 .   ? -7.253  -18.317 -15.965 1.000 35.382 0 695 HOH A O     1 ? 
HETATM 2879 O  O     . HOH F 5 .   ? 14.629  -7.590  -4.579  1.000 34.048 0 696 HOH A O     1 ? 
HETATM 2880 O  O     . HOH F 5 .   ? -12.621 15.268  -10.858 1.000 34.849 0 697 HOH A O     1 ? 
HETATM 2881 O  O     . HOH F 5 .   ? 0.124   -16.756 -0.534  1.000 20.945 0 698 HOH A O     1 ? 
HETATM 2882 O  O     . HOH F 5 .   ? -13.275 -4.496  8.847   1.000 12.999 0 699 HOH A O     1 ? 
HETATM 2883 O  O     . HOH F 5 .   ? 12.608  -19.276 4.654   1.000 14.211 0 700 HOH A O     1 ? 
HETATM 2884 O  O     . HOH F 5 .   ? 15.180  -17.560 11.122  1.000 21.494 0 701 HOH A O     1 ? 
HETATM 2885 O  O     . HOH F 5 .   ? -15.795 -8.294  3.168   1.000 21.208 0 702 HOH A O     1 ? 
HETATM 2886 O  O     . HOH F 5 .   ? -10.667 -17.763 -13.264 1.000 39.656 0 703 HOH A O     1 ? 
HETATM 2887 O  O     . HOH F 5 .   ? 19.356  -7.748  9.473   1.000 17.285 0 704 HOH A O     1 ? 
HETATM 2888 O  O     . HOH F 5 .   ? -15.292 -11.583 -24.468 1.000 26.004 0 705 HOH A O     1 ? 
HETATM 2889 O  O     . HOH F 5 .   ? -0.143  19.574  0.090   1.000 31.350 0 706 HOH A O     1 ? 
HETATM 2890 O  O     . HOH F 5 .   ? 6.360   -16.865 4.815   1.000 19.803 0 707 HOH A O     1 ? 
HETATM 2891 O  O     . HOH F 5 .   ? -7.673  12.508  28.040  1.000 23.948 0 708 HOH A O     1 ? 
HETATM 2892 O  O     . HOH F 5 .   ? -12.103 6.658   -3.860  1.000 29.378 0 709 HOH A O     1 ? 
HETATM 2893 O  O     . HOH F 5 .   ? -9.247  6.200   29.875  1.000 33.554 0 710 HOH A O     1 ? 
HETATM 2894 O  O     . HOH F 5 .   ? -2.439  16.490  0.151   1.000 20.322 0 711 HOH A O     1 ? 
HETATM 2895 O  O     . HOH F 5 .   ? -14.177 4.229   -7.449  1.000 22.421 0 712 HOH A O     1 ? 
HETATM 2896 O  O     . HOH F 5 .   ? -6.832  10.036  7.326   1.000 14.924 0 713 HOH A O     1 ? 
HETATM 2897 O  O     . HOH F 5 .   ? -3.961  8.859   25.399  1.000 28.912 0 714 HOH A O     1 ? 
HETATM 2898 O  O     . HOH F 5 .   ? 3.062   -18.853 5.870   1.000 38.664 0 715 HOH A O     1 ? 
HETATM 2899 O  O     . HOH F 5 .   ? 2.644   0.214   -6.572  1.000 26.357 0 716 HOH A O     1 ? 
HETATM 2900 O  O     . HOH F 5 .   ? 17.690  6.422   6.197   1.000 26.330 0 717 HOH A O     1 ? 
HETATM 2901 O  O     . HOH F 5 .   ? -0.909  19.585  6.342   1.000 36.526 0 718 HOH A O     1 ? 
HETATM 2902 O  O     . HOH F 5 .   ? -3.750  -17.149 -2.719  1.000 32.737 0 719 HOH A O     1 ? 
HETATM 2903 O  O     . HOH F 5 .   ? -4.701  17.022  11.725  1.000 35.042 0 720 HOH A O     1 ? 
HETATM 2904 O  O     . HOH F 5 .   ? 12.785  12.521  5.456   1.000 17.787 0 721 HOH A O     1 ? 
HETATM 2905 O  O     . HOH F 5 .   ? 17.946  -0.544  18.535  1.000 18.419 0 722 HOH A O     1 ? 
HETATM 2906 O  O     . HOH F 5 .   ? 9.081   8.207   -1.208  1.000 17.317 0 723 HOH A O     1 ? 
HETATM 2907 O  O     . HOH F 5 .   ? 10.425  -15.281 -1.217  1.000 36.913 0 724 HOH A O     1 ? 
HETATM 2908 O  O     . HOH F 5 .   ? -1.988  -13.653 8.091   1.000 23.554 0 725 HOH A O     1 ? 
HETATM 2909 O  O     . HOH F 5 .   ? 13.661  19.191  25.053  1.000 22.474 0 726 HOH A O     1 ? 
HETATM 2910 O  O     . HOH F 5 .   ? 19.539  -5.059  8.412   1.000 21.312 0 727 HOH A O     1 ? 
HETATM 2911 O  O     . HOH F 5 .   ? -8.711  -0.918  18.715  1.000 16.355 0 728 HOH A O     1 ? 
HETATM 2912 O  O     . HOH F 5 .   ? 11.334  18.435  27.583  1.000 28.254 0 729 HOH A O     1 ? 
HETATM 2913 O  O     . HOH F 5 .   ? -3.545  5.768   25.743  1.000 21.406 0 730 HOH A O     1 ? 
HETATM 2914 O  O     . HOH F 5 .   ? -9.832  -6.664  11.776  1.000 15.846 0 731 HOH A O     1 ? 
HETATM 2915 O  O     . HOH F 5 .   ? -2.676  -4.792  -9.188  1.000 29.024 0 732 HOH A O     1 ? 
HETATM 2916 O  O     . HOH F 5 .   ? 6.805   20.421  17.791  1.000 28.077 0 733 HOH A O     1 ? 
HETATM 2917 O  O     . HOH F 5 .   ? 15.285  12.419  5.913   1.000 35.353 0 734 HOH A O     1 ? 
HETATM 2918 O  O     . HOH F 5 .   ? 20.857  15.850  20.352  1.000 35.872 0 735 HOH A O     1 ? 
HETATM 2919 O  O     . HOH F 5 .   ? 15.988  -1.611  1.502   1.000 17.180 0 736 HOH A O     1 ? 
HETATM 2920 O  O     . HOH F 5 .   ? 12.591  -24.963 1.429   1.000 15.637 0 737 HOH A O     1 ? 
HETATM 2921 O  O     . HOH F 5 .   ? -1.540  15.775  -4.951  1.000 26.147 0 738 HOH A O     1 ? 
HETATM 2922 O  O     . HOH F 5 .   ? 9.897   21.095  13.095  1.000 18.885 0 739 HOH A O     1 ? 
HETATM 2923 O  O     . HOH F 5 .   ? 4.520   6.916   -3.022  1.000 36.920 0 740 HOH A O     1 ? 
HETATM 2924 O  O     . HOH F 5 .   ? -0.666  -11.796 17.216  1.000 21.638 0 741 HOH A O     1 ? 
HETATM 2925 O  O     . HOH F 5 .   ? 22.493  -16.379 4.253   1.000 26.419 0 742 HOH A O     1 ? 
HETATM 2926 O  O     . HOH F 5 .   ? -10.039 3.860   7.741   1.000 15.048 0 743 HOH A O     1 ? 
HETATM 2927 O  O     . HOH F 5 .   ? -13.615 6.865   17.452  1.000 18.952 0 744 HOH A O     1 ? 
HETATM 2928 O  O     . HOH F 5 .   ? 4.144   18.958  0.138   1.000 16.755 0 745 HOH A O     1 ? 
HETATM 2929 O  O     . HOH F 5 .   ? -1.304  -5.714  -4.339  1.000 38.701 0 746 HOH A O     1 ? 
HETATM 2930 O  O     . HOH F 5 .   ? 12.598  -17.213 3.016   1.000 13.675 0 747 HOH A O     1 ? 
HETATM 2931 O  O     . HOH F 5 .   ? 6.968   -6.397  0.356   1.000 35.276 0 748 HOH A O     1 ? 
HETATM 2932 O  O     . HOH F 5 .   ? -11.432 8.248   5.559   1.000 16.090 0 749 HOH A O     1 ? 
HETATM 2933 O  O     . HOH F 5 .   ? 2.000   -5.466  21.641  1.000 27.445 0 750 HOH A O     1 ? 
HETATM 2934 O  O     . HOH F 5 .   ? 20.408  -27.272 -0.890  1.000 39.915 0 751 HOH A O     1 ? 
HETATM 2935 O  O     . HOH F 5 .   ? -6.863  2.718   24.534  1.000 21.610 0 752 HOH A O     1 ? 
HETATM 2936 O  O     . HOH F 5 .   ? 2.564   -6.548  -10.396 1.000 34.116 0 753 HOH A O     1 ? 
HETATM 2937 O  O     . HOH F 5 .   ? 7.687   7.192   -3.592  1.000 30.234 0 754 HOH A O     1 ? 
HETATM 2938 O  O     . HOH F 5 .   ? 16.255  19.948  17.516  1.000 37.372 0 755 HOH A O     1 ? 
HETATM 2939 O  O     . HOH F 5 .   ? 12.349  19.578  13.276  1.000 24.822 0 756 HOH A O     1 ? 
HETATM 2940 O  O     . HOH F 5 .   ? -1.863  -13.442 14.291  1.000 30.978 0 757 HOH A O     1 ? 
HETATM 2941 O  O     . HOH F 5 .   ? 14.127  -23.899 -0.330  1.000 27.909 0 758 HOH A O     1 ? 
HETATM 2942 O  O     . HOH F 5 .   ? -12.707 14.897  23.394  1.000 25.527 0 759 HOH A O     1 ? 
HETATM 2943 O  O     . HOH F 5 .   ? 19.240  5.335   8.891   1.000 23.059 0 760 HOH A O     1 ? 
HETATM 2944 O  O     . HOH F 5 .   ? -7.242  8.746   31.749  1.000 38.132 0 761 HOH A O     1 ? 
HETATM 2945 O  O     . HOH F 5 .   ? -8.234  12.702  17.339  1.000 16.915 0 762 HOH A O     1 ? 
HETATM 2946 O  O     . HOH F 5 .   ? -9.005  -17.759 -8.859  1.000 34.395 0 763 HOH A O     1 ? 
HETATM 2947 O  O     . HOH F 5 .   ? -14.073 2.500   16.352  1.000 14.952 0 764 HOH A O     1 ? 
HETATM 2948 O  O     . HOH F 5 .   ? 17.118  -14.725 0.765   1.000 17.496 0 765 HOH A O     1 ? 
HETATM 2949 O  O     . HOH F 5 .   ? -5.951  12.148  11.617  1.000 11.202 0 766 HOH A O     1 ? 
HETATM 2950 O  O     . HOH F 5 .   ? 12.117  14.768  1.000   1.000 24.770 0 767 HOH A O     1 ? 
HETATM 2951 O  O     . HOH F 5 .   ? 1.370   11.656  -22.874 1.000 48.803 0 768 HOH A O     1 ? 
HETATM 2952 O  O     . HOH F 5 .   ? 16.978  -5.169  20.069  1.000 34.523 0 769 HOH A O     1 ? 
HETATM 2953 O  O     . HOH F 5 .   ? 18.739  10.627  11.337  1.000 26.854 0 770 HOH A O     1 ? 
HETATM 2954 O  O     . HOH F 5 .   ? -16.044 -16.145 -18.918 1.000 29.320 0 771 HOH A O     1 ? 
HETATM 2955 O  O     . HOH F 5 .   ? -10.985 -14.522 -28.707 1.000 36.657 0 772 HOH A O     1 ? 
HETATM 2956 O  O     . HOH F 5 .   ? 1.816   -9.345  -3.025  1.000 34.610 0 773 HOH A O     1 ? 
HETATM 2957 O  O     . HOH F 5 .   ? 4.249   1.995   -6.038  1.000 31.336 0 774 HOH A O     1 ? 
HETATM 2958 O  O     . HOH F 5 .   ? -3.238  10.983  27.826  1.000 38.943 0 775 HOH A O     1 ? 
HETATM 2959 O  O     . HOH F 5 .   ? 7.321   1.339   26.596  1.000 27.989 0 776 HOH A O     1 ? 
HETATM 2960 O  O     . HOH F 5 .   ? -8.465  19.367  -4.526  1.000 37.281 0 777 HOH A O     1 ? 
HETATM 2961 O  O     . HOH F 5 .   ? -14.860 2.477   -22.084 1.000 28.889 0 778 HOH A O     1 ? 
HETATM 2962 O  O     . HOH F 5 .   ? 5.997   -7.710  -12.100 1.000 36.977 0 779 HOH A O     1 ? 
HETATM 2963 O  O     . HOH F 5 .   ? 11.686  -20.853 2.652   1.000 34.200 0 780 HOH A O     1 ? 
HETATM 2964 O  O     . HOH F 5 .   ? -8.238  14.603  15.373  1.000 30.234 0 781 HOH A O     1 ? 
HETATM 2965 O  O     . HOH F 5 .   ? -5.346  19.108  -5.934  1.000 37.425 0 782 HOH A O     1 ? 
HETATM 2966 O  O     . HOH F 5 .   ? 6.171   -24.191 13.815  1.000 28.774 0 783 HOH A O     1 ? 
HETATM 2967 O  O     . HOH F 5 .   ? 22.747  3.777   1.414   1.000 23.997 0 784 HOH A O     1 ? 
HETATM 2968 O  O     . HOH F 5 .   ? 18.516  9.210   19.168  1.000 21.717 0 785 HOH A O     1 ? 
HETATM 2969 O  O     . HOH F 5 .   ? -2.930  -0.210  21.886  1.000 27.943 0 786 HOH A O     1 ? 
HETATM 2970 O  O     . HOH F 5 .   ? -9.295  12.995  5.655   1.000 35.078 0 787 HOH A O     1 ? 
HETATM 2971 O  O     . HOH F 5 .   ? -4.951  14.514  10.672  1.000 13.657 0 788 HOH A O     1 ? 
HETATM 2972 O  O     . HOH F 5 .   ? -0.414  -17.722 3.112   1.000 39.246 0 789 HOH A O     1 ? 
HETATM 2973 O  O     . HOH F 5 .   ? 9.844   13.684  26.248  1.000 23.234 0 790 HOH A O     1 ? 
HETATM 2974 O  O     . HOH F 5 .   ? -14.178 7.090   -0.709  1.000 42.996 0 791 HOH A O     1 ? 
HETATM 2975 O  O     . HOH F 5 .   ? -9.968  -18.283 -15.718 1.000 41.309 0 792 HOH A O     1 ? 
HETATM 2976 O  O     . HOH F 5 .   ? 11.601  24.145  19.177  1.000 36.404 0 793 HOH A O     1 ? 
HETATM 2977 O  O     . HOH F 5 .   ? -4.935  13.200  4.079   1.000 19.396 0 794 HOH A O     1 ? 
HETATM 2978 O  O     . HOH F 5 .   ? 4.074   -17.022 13.418  1.000 30.992 0 795 HOH A O     1 ? 
HETATM 2979 O  O     . HOH F 5 .   ? 9.659   15.726  1.234   1.000 28.488 0 796 HOH A O     1 ? 
HETATM 2980 O  O     . HOH F 5 .   ? 1.926   20.202  7.215   1.000 26.263 0 797 HOH A O     1 ? 
HETATM 2981 O  O     . HOH F 5 .   ? -12.013 5.936   -11.298 1.000 37.859 0 798 HOH A O     1 ? 
HETATM 2982 O  O     . HOH F 5 .   ? -1.868  4.797   -29.203 1.000 40.412 0 799 HOH A O     1 ? 
HETATM 2983 O  O     . HOH F 5 .   ? 1.416   3.870   27.551  1.000 34.481 0 800 HOH A O     1 ? 
HETATM 2984 O  O     . HOH F 5 .   ? -16.278 5.793   -17.159 1.000 32.445 0 801 HOH A O     1 ? 
HETATM 2985 O  O     . HOH F 5 .   ? -13.786 -8.637  10.790  1.000 31.057 0 802 HOH A O     1 ? 
HETATM 2986 O  O     . HOH F 5 .   ? 19.634  11.779  22.633  1.000 38.469 0 803 HOH A O     1 ? 
HETATM 2987 O  O     . HOH F 5 .   ? -6.907  11.292  30.224  1.000 33.650 0 804 HOH A O     1 ? 
HETATM 2988 O  O     . HOH F 5 .   ? 16.377  5.212   20.246  1.000 20.869 0 805 HOH A O     1 ? 
HETATM 2989 O  O     . HOH F 5 .   ? -3.927  17.853  14.377  1.000 41.890 0 806 HOH A O     1 ? 
HETATM 2990 O  O     . HOH F 5 .   ? 10.078  -18.145 1.409   1.000 39.003 0 807 HOH A O     1 ? 
HETATM 2991 O  O     . HOH F 5 .   ? 16.563  2.585   20.540  1.000 27.616 0 808 HOH A O     1 ? 
HETATM 2992 O  O     . HOH F 5 .   ? -14.236 6.100   9.727   1.000 28.038 0 809 HOH A O     1 ? 
HETATM 2993 O  O     . HOH F 5 .   ? 15.400  -27.236 -1.851  1.000 27.921 0 810 HOH A O     1 ? 
HETATM 2994 O  O     . HOH F 5 .   ? -2.071  17.455  2.730   1.000 27.914 0 811 HOH A O     1 ? 
HETATM 2995 O  O     . HOH F 5 .   ? -4.542  15.899  3.248   1.000 24.837 0 812 HOH A O     1 ? 
HETATM 2996 O  O     . HOH F 5 .   ? -13.940 -8.673  -26.869 1.000 26.479 0 813 HOH A O     1 ? 
HETATM 2997 O  O     . HOH F 5 .   ? -12.751 10.146  7.119   1.000 40.885 0 814 HOH A O     1 ? 
HETATM 2998 O  O     . HOH F 5 .   ? 19.547  -18.294 11.496  1.000 41.603 0 815 HOH A O     1 ? 
HETATM 2999 O  O     . HOH F 5 .   ? -14.949 -11.741 -3.772  1.000 35.712 0 816 HOH A O     1 ? 
HETATM 3000 O  O     . HOH F 5 .   ? 22.534  -14.556 9.992   1.000 32.504 0 817 HOH A O     1 ? 
HETATM 3001 O  O     . HOH F 5 .   ? -12.395 -5.897  11.070  1.000 19.302 0 818 HOH A O     1 ? 
HETATM 3002 O  O     . HOH F 5 .   ? 4.810   3.963   -2.840  1.000 37.933 0 819 HOH A O     1 ? 
HETATM 3003 O  O     . HOH F 5 .   ? 7.538   11.548  28.798  1.000 35.367 0 820 HOH A O     1 ? 
HETATM 3004 O  O     . HOH F 5 .   ? -12.063 5.464   5.527   1.000 21.942 0 821 HOH A O     1 ? 
HETATM 3005 O  O     . HOH F 5 .   ? 8.053   -23.636 9.733   1.000 28.844 0 822 HOH A O     1 ? 
HETATM 3006 O  O     . HOH F 5 .   ? -5.424  -6.945  22.005  1.000 45.408 0 823 HOH A O     1 ? 
HETATM 3007 O  O     . HOH F 5 .   ? -6.437  12.757  6.294   1.000 20.977 0 824 HOH A O     1 ? 
HETATM 3008 O  O     . HOH F 5 .   ? -1.885  -4.700  20.847  1.000 23.424 0 825 HOH A O     1 ? 
HETATM 3009 O  O     . HOH F 5 .   ? -8.337  13.260  12.123  1.000 28.386 0 826 HOH A O     1 ? 
HETATM 3010 O  O     . HOH F 5 .   ? 15.632  -8.700  14.832  1.000 26.650 0 827 HOH A O     1 ? 
HETATM 3011 O  O     . HOH F 5 .   ? 13.575  2.114   26.659  1.000 40.334 0 828 HOH A O     1 ? 
HETATM 3012 O  O     . HOH F 5 .   ? 17.431  12.451  7.940   1.000 29.183 0 829 HOH A O     1 ? 
HETATM 3013 O  O     . HOH F 5 .   ? -3.240  -6.868  20.548  1.000 34.377 0 830 HOH A O     1 ? 
HETATM 3014 O  O     . HOH F 5 .   ? 9.357   21.204  16.167  1.000 32.784 0 831 HOH A O     1 ? 
HETATM 3015 O  O     . HOH F 5 .   ? -17.773 -10.523 -24.611 1.000 44.212 0 832 HOH A O     1 ? 
HETATM 3016 O  O     . HOH F 5 .   ? -11.234 0.017   19.445  1.000 26.386 0 833 HOH A O     1 ? 
HETATM 3017 O  O     . HOH F 5 .   ? 17.833  -10.476 -3.376  1.000 32.363 0 834 HOH A O     1 ? 
HETATM 3018 O  O     . HOH F 5 .   ? 8.667   1.065   -1.646  1.000 36.716 0 835 HOH A O     1 ? 
HETATM 3019 O  O     . HOH F 5 .   ? -8.881  17.775  35.352  1.000 41.074 0 836 HOH A O     1 ? 
HETATM 3020 O  O     . HOH F 5 .   ? -3.140  -12.850 10.642  1.000 34.300 0 837 HOH A O     1 ? 
HETATM 3021 O  O     . HOH F 5 .   ? 13.368  -29.076 -0.919  1.000 18.466 0 838 HOH A O     1 ? 
HETATM 3022 O  O     . HOH F 5 .   ? 14.361  13.048  1.363   1.000 28.943 0 839 HOH A O     1 ? 
HETATM 3023 O  O     . HOH F 5 .   ? -9.553  -8.715  13.004  1.000 36.330 0 840 HOH A O     1 ? 
HETATM 3024 O  O     . HOH F 5 .   ? 17.420  -7.028  15.913  1.000 36.098 0 841 HOH A O     1 ? 
HETATM 3025 O  O     . HOH F 5 .   ? -0.794  17.509  -1.719  1.000 31.443 0 842 HOH A O     1 ? 
HETATM 3026 O  O     . HOH F 5 .   ? 17.314  14.170  14.532  1.000 36.276 0 843 HOH A O     1 ? 
HETATM 3027 O  O     . HOH F 5 .   ? 18.756  -2.344  16.653  1.000 34.715 0 844 HOH A O     1 ? 
HETATM 3028 O  O     . HOH F 5 .   ? 21.305  5.211   3.399   1.000 31.027 0 845 HOH A O     1 ? 
HETATM 3029 O  O     . HOH F 5 .   ? 13.612  20.313  10.810  1.000 42.003 0 846 HOH A O     1 ? 
HETATM 3030 O  O     . HOH F 5 .   ? -2.445  -2.630  22.380  1.000 27.168 0 847 HOH A O     1 ? 
HETATM 3031 O  O     . HOH F 5 .   ? -14.949 -0.215  16.886  1.000 28.840 0 848 HOH A O     1 ? 
HETATM 3032 O  O     . HOH F 5 .   ? -13.956 6.947   -11.048 1.000 41.497 0 849 HOH A O     1 ? 
HETATM 3033 O  O     . HOH F 5 .   ? 7.033   -7.589  -2.277  1.000 29.652 0 850 HOH A O     1 ? 
HETATM 3034 O  O     . HOH F 5 .   ? 14.707  11.694  3.623   1.000 23.368 0 851 HOH A O     1 ? 
HETATM 3035 O  O     . HOH F 5 .   ? -13.515 -2.293  17.507  1.000 46.001 0 852 HOH A O     1 ? 
HETATM 3036 O  O     . HOH F 5 .   ? -13.870 2.859   -29.002 1.000 37.102 0 853 HOH A O     1 ? 
HETATM 3037 O  O     . HOH F 5 .   ? 11.500  7.332   -1.859  1.000 32.971 0 854 HOH A O     1 ? 
HETATM 3038 O  O     . HOH F 5 .   ? 16.214  14.545  11.986  1.000 28.755 0 855 HOH A O     1 ? 
HETATM 3039 O  O     . HOH F 5 .   ? -6.944  13.882  -21.274 1.000 33.197 0 856 HOH A O     1 ? 
HETATM 3040 O  O     . HOH F 5 .   ? -4.862  1.266   25.900  1.000 34.569 0 857 HOH A O     1 ? 
HETATM 3041 O  O     . HOH F 5 .   ? 15.066  18.228  12.862  1.000 36.198 0 858 HOH A O     1 ? 
HETATM 3042 O  O     . HOH F 5 .   ? -9.396  -14.672 6.586   1.000 20.891 0 859 HOH A O     1 ? 
HETATM 3043 O  O     . HOH F 5 .   ? 14.805  8.794   -0.429  1.000 43.132 0 860 HOH A O     1 ? 
HETATM 3044 O  O     . HOH F 5 .   ? -13.559 13.612  21.336  1.000 29.425 0 861 HOH A O     1 ? 
HETATM 3045 O  O     . HOH F 5 .   ? -16.015 -13.464 -0.966  1.000 29.388 0 862 HOH A O     1 ? 
HETATM 3046 O  O     . HOH F 5 .   ? 12.855  -15.908 -1.912  1.000 39.117 0 863 HOH A O     1 ? 
HETATM 3047 O  O     . HOH F 5 .   ? -1.732  18.407  18.122  1.000 32.769 0 864 HOH A O     1 ? 
HETATM 3048 O  O     . HOH F 5 .   ? 9.270   3.705   29.896  1.000 36.528 0 865 HOH A O     1 ? 
HETATM 3049 O  O     . HOH F 5 .   ? 3.054   7.526   28.748  1.000 33.412 0 866 HOH A O     1 ? 
HETATM 3050 O  O     . HOH F 5 .   ? 16.583  -12.402 12.964  1.000 28.166 0 867 HOH A O     1 ? 
HETATM 3051 O  O     . HOH F 5 .   ? 15.634  9.621   2.161   1.000 32.482 0 868 HOH A O     1 ? 
HETATM 3052 O  O     . HOH F 5 .   ? -1.756  -18.086 -1.882  1.000 36.667 0 869 HOH A O     1 ? 
HETATM 3053 O  O     . HOH F 5 .   ? 18.746  20.295  -2.733  1.000 43.342 0 870 HOH A O     1 ? 
HETATM 3054 O  O     . HOH F 5 .   ? 18.498  6.905   20.438  1.000 35.628 0 871 HOH A O     1 ? 
HETATM 3055 O  O     . HOH F 5 .   ? -8.755  -18.094 3.531   1.000 40.122 0 872 HOH A O     1 ? 
HETATM 3056 O  O     . HOH F 5 .   ? -15.309 7.508   -13.268 1.000 41.698 0 873 HOH A O     1 ? 
HETATM 3057 O  O     . HOH F 5 .   ? 17.807  16.066  10.189  1.000 43.513 0 874 HOH A O     1 ? 
HETATM 3058 O  O     . HOH F 5 .   ? 26.328  -15.403 9.241   1.000 40.054 0 875 HOH A O     1 ? 
HETATM 3059 O  O     . HOH F 5 .   ? -18.761 6.731   -19.205 1.000 40.568 0 876 HOH A O     1 ? 
HETATM 3060 O  O     . HOH F 5 .   ? -15.605 10.372  7.461   1.000 37.079 0 877 HOH A O     1 ? 
HETATM 3061 O  O     . HOH F 5 .   ? -19.703 7.043   -21.772 1.000 45.439 0 878 HOH A O     1 ? 
# 
