data_8YSJ
# 
_entry.id   8YSJ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YSJ         pdb_00008ysj 10.2210/pdb8ysj/pdb 
WWPDB D_1300046301 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YSJ 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chyeah6599@nchu.edu.tw 
_pdbx_contact_author.name_first         Yeh 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7740-0446 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, Y.-C.' 1 ? 
'Yang, C.-S.' 2 ? 
'Hou, M.-H.'  3 ? 
'Chen, Y.'    4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            295 
_citation.language                  ? 
_citation.page_first                139534 
_citation.page_last                 139534 
_citation.title                     
'Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.139534 
_citation.pdbx_database_id_PubMed   39761885 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, C.S.'  1 ? 
primary 'Shie, M.Y.'  2 ? 
primary 'Huang, S.W.' 3 ? 
primary 'Wang, Y.C.'  4 ? 
primary 'Hou, M.H.'   5 ? 
primary 'Chen, C.J.'  6 ? 
primary 'Chen, Y.'    7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleotidyltransferase                                                            39217.918 1   ? ? ? ? 
2 non-polymer syn "5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine" 483.156   2   ? ? ? ? 
3 water       nat water                                                                             18.015    234 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine" 2KH 
3 water                                                                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PRO n 
1 4   VAL n 
1 5   GLN n 
1 6   LYS n 
1 7   GLN n 
1 8   PHE n 
1 9   ARG n 
1 10  GLU n 
1 11  PHE n 
1 12  HIS n 
1 13  ASP n 
1 14  ARG n 
1 15  ILE n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLN n 
1 20  TYR n 
1 21  ASP n 
1 22  GLU n 
1 23  ASN n 
1 24  GLN n 
1 25  THR n 
1 26  LEU n 
1 27  ARG n 
1 28  ASP n 
1 29  GLU n 
1 30  ARG n 
1 31  ASP n 
1 32  ALA n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  ALA n 
1 37  VAL n 
1 38  ARG n 
1 39  GLU n 
1 40  GLY n 
1 41  LEU n 
1 42  LYS n 
1 43  LYS n 
1 44  VAL n 
1 45  PHE n 
1 46  ALA n 
1 47  ASP n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  ALA n 
1 52  ALA n 
1 53  PRO n 
1 54  THR n 
1 55  PHE n 
1 56  THR n 
1 57  PRO n 
1 58  PHE n 
1 59  ASN n 
1 60  GLN n 
1 61  GLY n 
1 62  SER n 
1 63  TYR n 
1 64  ALA n 
1 65  MET n 
1 66  ASN n 
1 67  THR n 
1 68  GLY n 
1 69  VAL n 
1 70  LYS n 
1 71  PRO n 
1 72  LEU n 
1 73  GLU n 
1 74  GLY n 
1 75  GLY n 
1 76  GLU n 
1 77  TYR n 
1 78  ASP n 
1 79  ILE n 
1 80  ASP n 
1 81  VAL n 
1 82  GLY n 
1 83  ILE n 
1 84  ILE n 
1 85  LEU n 
1 86  ASN n 
1 87  ILE n 
1 88  ALA n 
1 89  LYS n 
1 90  ASP n 
1 91  ASP n 
1 92  HIS n 
1 93  ASP n 
1 94  PRO n 
1 95  VAL n 
1 96  GLU n 
1 97  VAL n 
1 98  LYS n 
1 99  LYS n 
1 100 TRP n 
1 101 ILE n 
1 102 ARG n 
1 103 ASP n 
1 104 ALA n 
1 105 LEU n 
1 106 LYS n 
1 107 ASP n 
1 108 TYR n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 ALA n 
1 113 GLU n 
1 114 ILE n 
1 115 ARG n 
1 116 ARG n 
1 117 SER n 
1 118 CYS n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 PHE n 
1 123 LYS n 
1 124 PRO n 
1 125 GLY n 
1 126 TYR n 
1 127 HIS n 
1 128 VAL n 
1 129 ASP n 
1 130 LEU n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 ALA n 
1 135 ASP n 
1 136 PRO n 
1 137 GLU n 
1 138 LEU n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 LEU n 
1 144 CYS n 
1 145 ILE n 
1 146 ALA n 
1 147 LYS n 
1 148 GLY n 
1 149 LYS n 
1 150 GLU n 
1 151 ASN n 
1 152 SER n 
1 153 GLY n 
1 154 ASP n 
1 155 GLU n 
1 156 HIS n 
1 157 ARG n 
1 158 LEU n 
1 159 TRP n 
1 160 GLN n 
1 161 ILE n 
1 162 SER n 
1 163 ASP n 
1 164 PRO n 
1 165 GLN n 
1 166 GLY n 
1 167 PHE n 
1 168 GLN n 
1 169 ASP n 
1 170 ARG n 
1 171 ILE n 
1 172 ALA n 
1 173 SER n 
1 174 LYS n 
1 175 LEU n 
1 176 SER n 
1 177 GLY n 
1 178 ASP n 
1 179 ASP n 
1 180 ALA n 
1 181 ALA n 
1 182 GLN n 
1 183 PHE n 
1 184 ARG n 
1 185 ARG n 
1 186 CYS n 
1 187 ILE n 
1 188 ARG n 
1 189 TYR n 
1 190 LEU n 
1 191 LYS n 
1 192 ARG n 
1 193 TRP n 
1 194 ARG n 
1 195 ASP n 
1 196 PHE n 
1 197 ARG n 
1 198 PHE n 
1 199 SER n 
1 200 SER n 
1 201 ASP n 
1 202 GLY n 
1 203 ASN n 
1 204 ALA n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 LEU n 
1 212 THR n 
1 213 ALA n 
1 214 ALA n 
1 215 ALA n 
1 216 TYR n 
1 217 TRP n 
1 218 TRP n 
1 219 PHE n 
1 220 GLN n 
1 221 VAL n 
1 222 SER n 
1 223 LYS n 
1 224 ARG n 
1 225 THR n 
1 226 ASP n 
1 227 PRO n 
1 228 VAL n 
1 229 SER n 
1 230 GLN n 
1 231 ASN n 
1 232 VAL n 
1 233 THR n 
1 234 TYR n 
1 235 ASP n 
1 236 ASP n 
1 237 ARG n 
1 238 ASP n 
1 239 ALA n 
1 240 LEU n 
1 241 GLU n 
1 242 GLN n 
1 243 PHE n 
1 244 VAL n 
1 245 GLN n 
1 246 THR n 
1 247 MET n 
1 248 LEU n 
1 249 ASP n 
1 250 ASN n 
1 251 PHE n 
1 252 HIS n 
1 253 ASP n 
1 254 THR n 
1 255 TRP n 
1 256 ASP n 
1 257 SER n 
1 258 LYS n 
1 259 ASP n 
1 260 GLN n 
1 261 ARG n 
1 262 SER n 
1 263 TYR n 
1 264 PRO n 
1 265 ARG n 
1 266 LEU n 
1 267 THR n 
1 268 VAL n 
1 269 GLU n 
1 270 LEU n 
1 271 PRO n 
1 272 VAL n 
1 273 GLN n 
1 274 PRO n 
1 275 TYR n 
1 276 ASN n 
1 277 ASP n 
1 278 VAL n 
1 279 PHE n 
1 280 GLU n 
1 281 LYS n 
1 282 MET n 
1 283 THR n 
1 284 GLY n 
1 285 MET n 
1 286 GLN n 
1 287 MET n 
1 288 GLU n 
1 289 SER n 
1 290 PHE n 
1 291 LYS n 
1 292 SER n 
1 293 LYS n 
1 294 LEU n 
1 295 GLN n 
1 296 ALA n 
1 297 LEU n 
1 298 LEU n 
1 299 ASN n 
1 300 ALA n 
1 301 LEU n 
1 302 LYS n 
1 303 THR n 
1 304 ALA n 
1 305 LYS n 
1 306 SER n 
1 307 ARG n 
1 308 LEU n 
1 309 GLU n 
1 310 LEU n 
1 311 HIS n 
1 312 ASP n 
1 313 ALA n 
1 314 CYS n 
1 315 LYS n 
1 316 ALA n 
1 317 LEU n 
1 318 ALA n 
1 319 ASP n 
1 320 HIS n 
1 321 PHE n 
1 322 GLY n 
1 323 SER n 
1 324 GLU n 
1 325 PHE n 
1 326 PRO n 
1 327 VAL n 
1 328 PRO n 
1 329 GLU n 
1 330 LYS n 
1 331 ASP n 
1 332 LYS n 
1 333 SER n 
1 334 ALA n 
1 335 VAL n 
1 336 HIS n 
1 337 THR n 
1 338 ALA n 
1 339 PRO n 
1 340 ALA n 
1 341 ILE n 
1 342 VAL n 
1 343 GLY n 
1 344 SER n 
1 345 GLY n 
1 346 SER n 
1 347 SER n 
1 348 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   348 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 DVJ83_15700 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Deinococcus wulumuqiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     980427 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
2KH non-polymer         . "5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine" ? 'C9 H16 N3 O14 P3' 
483.156 
ALA 'L-peptide linking' y ALANINE                                                                           ? 'C3 H7 N O2'       
89.093  
ARG 'L-peptide linking' y ARGININE                                                                          ? 'C6 H15 N4 O2 1'   
175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                        ? 'C4 H8 N2 O3'      
132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                   ? 'C4 H7 N O4'       
133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                          ? 'C3 H7 N O2 S'     
121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                         ? 'C5 H10 N2 O3'     
146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                   ? 'C5 H9 N O4'       
147.129 
GLY 'peptide linking'   y GLYCINE                                                                           ? 'C2 H5 N O2'       
75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                         ? 'C6 H10 N3 O2 1'   
156.162 
HOH non-polymer         . WATER                                                                             ? 'H2 O'             
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                        ? 'C6 H13 N O2'      
131.173 
LEU 'L-peptide linking' y LEUCINE                                                                           ? 'C6 H13 N O2'      
131.173 
LYS 'L-peptide linking' y LYSINE                                                                            ? 'C6 H15 N2 O2 1'   
147.195 
MET 'L-peptide linking' y METHIONINE                                                                        ? 'C5 H11 N O2 S'    
149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                     ? 'C9 H11 N O2'      
165.189 
PRO 'L-peptide linking' y PROLINE                                                                           ? 'C5 H9 N O2'       
115.130 
SER 'L-peptide linking' y SERINE                                                                            ? 'C3 H7 N O3'       
105.093 
THR 'L-peptide linking' y THREONINE                                                                         ? 'C4 H9 N O3'       
119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                        ? 'C11 H12 N2 O2'    
204.225 
TYR 'L-peptide linking' y TYROSINE                                                                          ? 'C9 H11 N O3'      
181.189 
VAL 'L-peptide linking' y VALINE                                                                            ? 'C5 H11 N O2'      
117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PRO 3   3   3   PRO PRO A . n 
A 1 4   VAL 4   4   4   VAL VAL A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ALA 18  18  18  ALA ALA A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ASP 28  28  28  ASP ASP A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  ARG 30  30  30  ARG ARG A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  THR 35  35  35  THR THR A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  PRO 53  53  53  PRO PRO A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  TYR 63  63  63  TYR TYR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  MET 65  65  65  MET MET A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 CYS 118 118 118 CYS CYS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 HIS 127 127 127 HIS HIS A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 GLY 141 141 141 GLY GLY A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 GLY 153 153 ?   ?   ?   A . n 
A 1 154 ASP 154 154 ?   ?   ?   A . n 
A 1 155 GLU 155 155 ?   ?   ?   A . n 
A 1 156 HIS 156 156 ?   ?   ?   A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 PRO 164 164 164 PRO PRO A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLN 168 168 168 GLN GLN A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 CYS 186 186 186 CYS CYS A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 VAL 221 221 221 VAL VAL A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLN 230 230 230 GLN GLN A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 TYR 234 234 234 TYR TYR A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 ARG 237 237 237 ARG ARG A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 PHE 243 243 243 PHE PHE A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 MET 247 247 247 MET MET A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 ASP 249 249 249 ASP ASP A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 HIS 252 252 252 HIS HIS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 TRP 255 255 255 TRP TRP A . n 
A 1 256 ASP 256 256 256 ASP ASP A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 PRO 264 264 264 PRO PRO A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 GLU 269 269 269 GLU GLU A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 ASP 277 277 277 ASP ASP A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 LYS 281 281 281 LYS LYS A . n 
A 1 282 MET 282 282 282 MET MET A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 SER 289 289 289 SER SER A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 GLN 295 295 295 GLN GLN A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 LEU 297 297 297 LEU LEU A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 SER 306 306 306 SER SER A . n 
A 1 307 ARG 307 307 307 ARG ARG A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 GLU 309 309 309 GLU GLU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 HIS 311 311 311 HIS HIS A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 ALA 318 318 318 ALA ALA A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 320 HIS HIS A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 GLU 324 324 324 GLU GLU A . n 
A 1 325 PHE 325 325 325 PHE PHE A . n 
A 1 326 PRO 326 326 326 PRO PRO A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 PRO 328 328 328 PRO PRO A . n 
A 1 329 GLU 329 329 329 GLU GLU A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 ASP 331 331 ?   ?   ?   A . n 
A 1 332 LYS 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 ALA 334 334 ?   ?   ?   A . n 
A 1 335 VAL 335 335 ?   ?   ?   A . n 
A 1 336 HIS 336 336 ?   ?   ?   A . n 
A 1 337 THR 337 337 ?   ?   ?   A . n 
A 1 338 ALA 338 338 ?   ?   ?   A . n 
A 1 339 PRO 339 339 ?   ?   ?   A . n 
A 1 340 ALA 340 340 ?   ?   ?   A . n 
A 1 341 ILE 341 341 ?   ?   ?   A . n 
A 1 342 VAL 342 342 ?   ?   ?   A . n 
A 1 343 GLY 343 343 ?   ?   ?   A . n 
A 1 344 SER 344 344 ?   ?   ?   A . n 
A 1 345 GLY 345 345 ?   ?   ?   A . n 
A 1 346 SER 346 346 ?   ?   ?   A . n 
A 1 347 SER 347 347 ?   ?   ?   A . n 
A 1 348 GLY 348 348 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        2KH 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   2KH 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 2KH 1   401 401 2KH LIG A . 
C 2 2KH 1   402 402 2KH LIG A . 
D 3 HOH 1   501 590 HOH HOH A . 
D 3 HOH 2   502 684 HOH HOH A . 
D 3 HOH 3   503 693 HOH HOH A . 
D 3 HOH 4   504 669 HOH HOH A . 
D 3 HOH 5   505 692 HOH HOH A . 
D 3 HOH 6   506 628 HOH HOH A . 
D 3 HOH 7   507 722 HOH HOH A . 
D 3 HOH 8   508 678 HOH HOH A . 
D 3 HOH 9   509 657 HOH HOH A . 
D 3 HOH 10  510 629 HOH HOH A . 
D 3 HOH 11  511 543 HOH HOH A . 
D 3 HOH 12  512 572 HOH HOH A . 
D 3 HOH 13  513 695 HOH HOH A . 
D 3 HOH 14  514 566 HOH HOH A . 
D 3 HOH 15  515 615 HOH HOH A . 
D 3 HOH 16  516 651 HOH HOH A . 
D 3 HOH 17  517 598 HOH HOH A . 
D 3 HOH 18  518 515 HOH HOH A . 
D 3 HOH 19  519 620 HOH HOH A . 
D 3 HOH 20  520 624 HOH HOH A . 
D 3 HOH 21  521 600 HOH HOH A . 
D 3 HOH 22  522 544 HOH HOH A . 
D 3 HOH 23  523 523 HOH HOH A . 
D 3 HOH 24  524 516 HOH HOH A . 
D 3 HOH 25  525 579 HOH HOH A . 
D 3 HOH 26  526 705 HOH HOH A . 
D 3 HOH 27  527 539 HOH HOH A . 
D 3 HOH 28  528 666 HOH HOH A . 
D 3 HOH 29  529 547 HOH HOH A . 
D 3 HOH 30  530 565 HOH HOH A . 
D 3 HOH 31  531 686 HOH HOH A . 
D 3 HOH 32  532 641 HOH HOH A . 
D 3 HOH 33  533 668 HOH HOH A . 
D 3 HOH 34  534 556 HOH HOH A . 
D 3 HOH 35  535 527 HOH HOH A . 
D 3 HOH 36  536 520 HOH HOH A . 
D 3 HOH 37  537 503 HOH HOH A . 
D 3 HOH 38  538 517 HOH HOH A . 
D 3 HOH 39  539 588 HOH HOH A . 
D 3 HOH 40  540 630 HOH HOH A . 
D 3 HOH 41  541 639 HOH HOH A . 
D 3 HOH 42  542 511 HOH HOH A . 
D 3 HOH 43  543 609 HOH HOH A . 
D 3 HOH 44  544 528 HOH HOH A . 
D 3 HOH 45  545 625 HOH HOH A . 
D 3 HOH 46  546 604 HOH HOH A . 
D 3 HOH 47  547 506 HOH HOH A . 
D 3 HOH 48  548 688 HOH HOH A . 
D 3 HOH 49  549 568 HOH HOH A . 
D 3 HOH 50  550 690 HOH HOH A . 
D 3 HOH 51  551 677 HOH HOH A . 
D 3 HOH 52  552 581 HOH HOH A . 
D 3 HOH 53  553 554 HOH HOH A . 
D 3 HOH 54  554 718 HOH HOH A . 
D 3 HOH 55  555 571 HOH HOH A . 
D 3 HOH 56  556 713 HOH HOH A . 
D 3 HOH 57  557 525 HOH HOH A . 
D 3 HOH 58  558 607 HOH HOH A . 
D 3 HOH 59  559 559 HOH HOH A . 
D 3 HOH 60  560 612 HOH HOH A . 
D 3 HOH 61  561 638 HOH HOH A . 
D 3 HOH 62  562 595 HOH HOH A . 
D 3 HOH 63  563 682 HOH HOH A . 
D 3 HOH 64  564 532 HOH HOH A . 
D 3 HOH 65  565 646 HOH HOH A . 
D 3 HOH 66  566 658 HOH HOH A . 
D 3 HOH 67  567 540 HOH HOH A . 
D 3 HOH 68  568 534 HOH HOH A . 
D 3 HOH 69  569 597 HOH HOH A . 
D 3 HOH 70  570 558 HOH HOH A . 
D 3 HOH 71  571 661 HOH HOH A . 
D 3 HOH 72  572 617 HOH HOH A . 
D 3 HOH 73  573 596 HOH HOH A . 
D 3 HOH 74  574 529 HOH HOH A . 
D 3 HOH 75  575 716 HOH HOH A . 
D 3 HOH 76  576 501 HOH HOH A . 
D 3 HOH 77  577 583 HOH HOH A . 
D 3 HOH 78  578 504 HOH HOH A . 
D 3 HOH 79  579 611 HOH HOH A . 
D 3 HOH 80  580 536 HOH HOH A . 
D 3 HOH 81  581 637 HOH HOH A . 
D 3 HOH 82  582 574 HOH HOH A . 
D 3 HOH 83  583 508 HOH HOH A . 
D 3 HOH 84  584 584 HOH HOH A . 
D 3 HOH 85  585 500 HOH HOH A . 
D 3 HOH 86  586 694 HOH HOH A . 
D 3 HOH 87  587 538 HOH HOH A . 
D 3 HOH 88  588 541 HOH HOH A . 
D 3 HOH 89  589 662 HOH HOH A . 
D 3 HOH 90  590 723 HOH HOH A . 
D 3 HOH 91  591 675 HOH HOH A . 
D 3 HOH 92  592 648 HOH HOH A . 
D 3 HOH 93  593 665 HOH HOH A . 
D 3 HOH 94  594 505 HOH HOH A . 
D 3 HOH 95  595 698 HOH HOH A . 
D 3 HOH 96  596 519 HOH HOH A . 
D 3 HOH 97  597 715 HOH HOH A . 
D 3 HOH 98  598 721 HOH HOH A . 
D 3 HOH 99  599 592 HOH HOH A . 
D 3 HOH 100 600 561 HOH HOH A . 
D 3 HOH 101 601 557 HOH HOH A . 
D 3 HOH 102 602 635 HOH HOH A . 
D 3 HOH 103 603 650 HOH HOH A . 
D 3 HOH 104 604 608 HOH HOH A . 
D 3 HOH 105 605 619 HOH HOH A . 
D 3 HOH 106 606 589 HOH HOH A . 
D 3 HOH 107 607 613 HOH HOH A . 
D 3 HOH 108 608 610 HOH HOH A . 
D 3 HOH 109 609 502 HOH HOH A . 
D 3 HOH 110 610 546 HOH HOH A . 
D 3 HOH 111 611 548 HOH HOH A . 
D 3 HOH 112 612 633 HOH HOH A . 
D 3 HOH 113 613 533 HOH HOH A . 
D 3 HOH 114 614 531 HOH HOH A . 
D 3 HOH 115 615 509 HOH HOH A . 
D 3 HOH 116 616 521 HOH HOH A . 
D 3 HOH 117 617 514 HOH HOH A . 
D 3 HOH 118 618 643 HOH HOH A . 
D 3 HOH 119 619 562 HOH HOH A . 
D 3 HOH 120 620 676 HOH HOH A . 
D 3 HOH 121 621 576 HOH HOH A . 
D 3 HOH 122 622 553 HOH HOH A . 
D 3 HOH 123 623 567 HOH HOH A . 
D 3 HOH 124 624 708 HOH HOH A . 
D 3 HOH 125 625 640 HOH HOH A . 
D 3 HOH 126 626 681 HOH HOH A . 
D 3 HOH 127 627 575 HOH HOH A . 
D 3 HOH 128 628 672 HOH HOH A . 
D 3 HOH 129 629 587 HOH HOH A . 
D 3 HOH 130 630 564 HOH HOH A . 
D 3 HOH 131 631 719 HOH HOH A . 
D 3 HOH 132 632 582 HOH HOH A . 
D 3 HOH 133 633 626 HOH HOH A . 
D 3 HOH 134 634 691 HOH HOH A . 
D 3 HOH 135 635 621 HOH HOH A . 
D 3 HOH 136 636 569 HOH HOH A . 
D 3 HOH 137 637 513 HOH HOH A . 
D 3 HOH 138 638 555 HOH HOH A . 
D 3 HOH 139 639 632 HOH HOH A . 
D 3 HOH 140 640 605 HOH HOH A . 
D 3 HOH 141 641 510 HOH HOH A . 
D 3 HOH 142 642 729 HOH HOH A . 
D 3 HOH 143 643 667 HOH HOH A . 
D 3 HOH 144 644 550 HOH HOH A . 
D 3 HOH 145 645 570 HOH HOH A . 
D 3 HOH 146 646 573 HOH HOH A . 
D 3 HOH 147 647 599 HOH HOH A . 
D 3 HOH 148 648 586 HOH HOH A . 
D 3 HOH 149 649 683 HOH HOH A . 
D 3 HOH 150 650 660 HOH HOH A . 
D 3 HOH 151 651 507 HOH HOH A . 
D 3 HOH 152 652 552 HOH HOH A . 
D 3 HOH 153 653 645 HOH HOH A . 
D 3 HOH 154 654 618 HOH HOH A . 
D 3 HOH 155 655 659 HOH HOH A . 
D 3 HOH 156 656 524 HOH HOH A . 
D 3 HOH 157 657 711 HOH HOH A . 
D 3 HOH 158 658 602 HOH HOH A . 
D 3 HOH 159 659 730 HOH HOH A . 
D 3 HOH 160 660 664 HOH HOH A . 
D 3 HOH 161 661 649 HOH HOH A . 
D 3 HOH 162 662 731 HOH HOH A . 
D 3 HOH 163 663 535 HOH HOH A . 
D 3 HOH 164 664 530 HOH HOH A . 
D 3 HOH 165 665 687 HOH HOH A . 
D 3 HOH 166 666 670 HOH HOH A . 
D 3 HOH 167 667 563 HOH HOH A . 
D 3 HOH 168 668 644 HOH HOH A . 
D 3 HOH 169 669 580 HOH HOH A . 
D 3 HOH 170 670 551 HOH HOH A . 
D 3 HOH 171 671 578 HOH HOH A . 
D 3 HOH 172 672 593 HOH HOH A . 
D 3 HOH 173 673 717 HOH HOH A . 
D 3 HOH 174 674 614 HOH HOH A . 
D 3 HOH 175 675 526 HOH HOH A . 
D 3 HOH 176 676 726 HOH HOH A . 
D 3 HOH 177 677 512 HOH HOH A . 
D 3 HOH 178 678 702 HOH HOH A . 
D 3 HOH 179 679 522 HOH HOH A . 
D 3 HOH 180 680 537 HOH HOH A . 
D 3 HOH 181 681 594 HOH HOH A . 
D 3 HOH 182 682 642 HOH HOH A . 
D 3 HOH 183 683 577 HOH HOH A . 
D 3 HOH 184 684 549 HOH HOH A . 
D 3 HOH 185 685 634 HOH HOH A . 
D 3 HOH 186 686 720 HOH HOH A . 
D 3 HOH 187 687 724 HOH HOH A . 
D 3 HOH 188 688 700 HOH HOH A . 
D 3 HOH 189 689 518 HOH HOH A . 
D 3 HOH 190 690 709 HOH HOH A . 
D 3 HOH 191 691 652 HOH HOH A . 
D 3 HOH 192 692 712 HOH HOH A . 
D 3 HOH 193 693 647 HOH HOH A . 
D 3 HOH 194 694 679 HOH HOH A . 
D 3 HOH 195 695 603 HOH HOH A . 
D 3 HOH 196 696 622 HOH HOH A . 
D 3 HOH 197 697 655 HOH HOH A . 
D 3 HOH 198 698 591 HOH HOH A . 
D 3 HOH 199 699 631 HOH HOH A . 
D 3 HOH 200 700 680 HOH HOH A . 
D 3 HOH 201 701 636 HOH HOH A . 
D 3 HOH 202 702 704 HOH HOH A . 
D 3 HOH 203 703 714 HOH HOH A . 
D 3 HOH 204 704 732 HOH HOH A . 
D 3 HOH 205 705 545 HOH HOH A . 
D 3 HOH 206 706 673 HOH HOH A . 
D 3 HOH 207 707 706 HOH HOH A . 
D 3 HOH 208 708 671 HOH HOH A . 
D 3 HOH 209 709 733 HOH HOH A . 
D 3 HOH 210 710 707 HOH HOH A . 
D 3 HOH 211 711 653 HOH HOH A . 
D 3 HOH 212 712 585 HOH HOH A . 
D 3 HOH 213 713 542 HOH HOH A . 
D 3 HOH 214 714 606 HOH HOH A . 
D 3 HOH 215 715 623 HOH HOH A . 
D 3 HOH 216 716 663 HOH HOH A . 
D 3 HOH 217 717 560 HOH HOH A . 
D 3 HOH 218 718 685 HOH HOH A . 
D 3 HOH 219 719 656 HOH HOH A . 
D 3 HOH 220 720 696 HOH HOH A . 
D 3 HOH 221 721 616 HOH HOH A . 
D 3 HOH 222 722 701 HOH HOH A . 
D 3 HOH 223 723 727 HOH HOH A . 
D 3 HOH 224 724 697 HOH HOH A . 
D 3 HOH 225 725 601 HOH HOH A . 
D 3 HOH 226 726 710 HOH HOH A . 
D 3 HOH 227 727 654 HOH HOH A . 
D 3 HOH 228 728 699 HOH HOH A . 
D 3 HOH 229 729 674 HOH HOH A . 
D 3 HOH 230 730 627 HOH HOH A . 
D 3 HOH 231 731 728 HOH HOH A . 
D 3 HOH 232 732 689 HOH HOH A . 
D 3 HOH 233 733 703 HOH HOH A . 
D 3 HOH 234 734 725 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0267 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? Blu-Ice  ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
# 
_cell.angle_alpha                  74.396 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   73.126 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  84.271 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YSJ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.346 
_cell.length_a_esd                 ? 
_cell.length_b                     46.244 
_cell.length_b_esd                 ? 
_cell.length_c                     61.058 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        1 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YSJ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YSJ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M Bis-Tris pH6.5, 
20 % w/v PEG 5000 MME.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-10-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.99984 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 05A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.99984 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 05A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YSJ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.9 
_reflns.d_resolution_low                               30 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26385 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           95.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          32.553 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.024 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.97 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2673 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.972 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.163 
_refine.aniso_B[1][2]                            -0.182 
_refine.aniso_B[1][3]                            0.053 
_refine.aniso_B[2][2]                            -0.079 
_refine.aniso_B[2][3]                            0.127 
_refine.aniso_B[3][3]                            -0.022 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.599 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.950 
_refine.correlation_coeff_Fo_to_Fc_free          0.932 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YSJ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.903 
_refine.ls_d_res_low                             28.287 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26372 
_refine.ls_number_reflns_R_free                  1381 
_refine.ls_number_reflns_R_work                  24991 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    94.263 
_refine.ls_percent_reflns_R_free                 5.237 
_refine.ls_R_factor_all                          0.173 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2074 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1708 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.157 
_refine.pdbx_overall_ESU_R_Free                  0.140 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             2.895 
_refine.overall_SU_ML                            0.086 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2616 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             234 
_refine_hist.number_atoms_total               2908 
_refine_hist.d_res_high                       1.903 
_refine_hist.d_res_low                        28.287 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.013  2735 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2496 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.431  1.682  3708 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.338  1.593  5745 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.680  5.000  324  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 32.597 22.050 161  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.068 15.000 460  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.985 15.000 22   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.073  0.200  341  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  3078 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  652  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.211  0.200  568  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.182  0.200  2343 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.173  0.200  1342 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.078  0.200  1278 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.158  0.200  161  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.013  0.200  2    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.173  0.200  17   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.185  0.200  51   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.163  0.200  16   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.415  2.407  1302 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.415  2.405  1301 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 3.527  3.589  1624 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.526  3.591  1625 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.401  2.968  1433 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.945  2.731  1374 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.340  4.352  2084 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.569  3.962  1991 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 7.963  29.340 3144 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.443  27.818 3040 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.903 1.952  . . 102 1714 86.3939 . . . . 0.183 . . . . . . . . . . . 0.264 
'X-RAY DIFFRACTION' 1.952 2.005  . . 85  1830 96.0381 . . . . 0.187 . . . . . . . . . . . 0.200 
'X-RAY DIFFRACTION' 2.005 2.063  . . 97  1790 96.5711 . . . . 0.178 . . . . . . . . . . . 0.232 
'X-RAY DIFFRACTION' 2.063 2.127  . . 75  1776 97.1144 . . . . 0.172 . . . . . . . . . . . 0.276 
'X-RAY DIFFRACTION' 2.127 2.196  . . 93  1692 96.4865 . . . . 0.164 . . . . . . . . . . . 0.213 
'X-RAY DIFFRACTION' 2.196 2.273  . . 84  1606 96.5714 . . . . 0.158 . . . . . . . . . . . 0.193 
'X-RAY DIFFRACTION' 2.273 2.358  . . 103 1608 97.4374 . . . . 0.145 . . . . . . . . . . . 0.187 
'X-RAY DIFFRACTION' 2.358 2.453  . . 89  1481 96.5560 . . . . 0.151 . . . . . . . . . . . 0.216 
'X-RAY DIFFRACTION' 2.453 2.562  . . 73  1453 96.4602 . . . . 0.167 . . . . . . . . . . . 0.225 
'X-RAY DIFFRACTION' 2.562 2.686  . . 74  1383 96.1082 . . . . 0.160 . . . . . . . . . . . 0.210 
'X-RAY DIFFRACTION' 2.686 2.830  . . 77  1288 95.3878 . . . . 0.168 . . . . . . . . . . . 0.225 
'X-RAY DIFFRACTION' 2.830 3.000  . . 78  1229 95.3319 . . . . 0.165 . . . . . . . . . . . 0.165 
'X-RAY DIFFRACTION' 3.000 3.205  . . 69  1126 91.9938 . . . . 0.171 . . . . . . . . . . . 0.218 
'X-RAY DIFFRACTION' 3.205 3.458  . . 59  1008 90.3472 . . . . 0.173 . . . . . . . . . . . 0.171 
'X-RAY DIFFRACTION' 3.458 3.783  . . 61  925  88.2722 . . . . 0.176 . . . . . . . . . . . 0.177 
'X-RAY DIFFRACTION' 3.783 4.221  . . 41  827  88.7526 . . . . 0.173 . . . . . . . . . . . 0.232 
'X-RAY DIFFRACTION' 4.221 4.858  . . 46  732  89.4253 . . . . 0.161 . . . . . . . . . . . 0.203 
'X-RAY DIFFRACTION' 4.858 5.912  . . 38  689  94.6615 . . . . 0.194 . . . . . . . . . . . 0.219 
'X-RAY DIFFRACTION' 5.912 8.203  . . 22  522  95.2715 . . . . 0.209 . . . . . . . . . . . 0.254 
'X-RAY DIFFRACTION' 8.203 28.287 . . 15  312  93.6963 . . . . 0.194 . . . . . . . . . . . 0.164 
# 
_struct.entry_id                     8YSJ 
_struct.title                        'Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with UMPNPP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YSJ 
_struct_keywords.text            'CD-NTase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A345ILN6_9DEIO 
_struct_ref.pdbx_db_accession          A0A345ILN6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YSJ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 348 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A345ILN6 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  348 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       348 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 4   ? LYS A 16  ? VAL A 4   LYS A 16  1 ? 13 
HELX_P HELX_P2  AA2 GLN A 19  ? GLU A 22  ? GLN A 19  GLU A 22  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 23  ? ALA A 46  ? ASN A 23  ALA A 46  1 ? 24 
HELX_P HELX_P4  AA4 GLY A 61  ? ASN A 66  ? GLY A 61  ASN A 66  1 ? 6  
HELX_P HELX_P5  AA5 ALA A 88  ? HIS A 92  ? ALA A 88  HIS A 92  5 ? 5  
HELX_P HELX_P6  AA6 ASP A 93  ? LEU A 105 ? ASP A 93  LEU A 105 1 ? 13 
HELX_P HELX_P7  AA7 PRO A 136 ? SER A 139 ? PRO A 136 SER A 139 5 ? 4  
HELX_P HELX_P8  AA8 ASP A 163 ? LYS A 174 ? ASP A 163 LYS A 174 1 ? 12 
HELX_P HELX_P9  AA9 SER A 176 ? PHE A 198 ? SER A 176 PHE A 198 1 ? 23 
HELX_P HELX_P10 AB1 ASP A 201 ? ALA A 205 ? ASP A 201 ALA A 205 5 ? 5  
HELX_P HELX_P11 AB2 LEU A 207 ? PHE A 219 ? LEU A 207 PHE A 219 1 ? 13 
HELX_P HELX_P12 AB3 ASP A 235 ? ASN A 250 ? ASP A 235 ASN A 250 1 ? 16 
HELX_P HELX_P13 AB4 THR A 283 ? ARG A 307 ? THR A 283 ARG A 307 1 ? 25 
HELX_P HELX_P14 AB5 GLU A 309 ? GLY A 322 ? GLU A 309 GLY A 322 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           273 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            273 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    274 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     274 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       2.52 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? GLN A 60  ? PHE A 55  GLN A 60  
AA1 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA1 3 TYR A 126 ? ALA A 134 ? TYR A 126 ALA A 134 
AA1 4 VAL A 119 ? LYS A 123 ? VAL A 119 LYS A 123 
AA1 5 ALA A 112 ? ILE A 114 ? ALA A 112 ILE A 114 
AA2 1 CYS A 144 ? ALA A 146 ? CYS A 144 ALA A 146 
AA2 2 TRP A 159 ? ILE A 161 ? TRP A 159 ILE A 161 
AA3 1 LYS A 223 ? THR A 225 ? LYS A 223 THR A 225 
AA3 2 VAL A 232 ? TYR A 234 ? VAL A 232 TYR A 234 
AA4 1 PHE A 251 ? ASP A 256 ? PHE A 251 ASP A 256 
AA4 2 ARG A 261 ? LEU A 266 ? ARG A 261 LEU A 266 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 58  ? N PHE A 58  O GLY A 82  ? O GLY A 82  
AA1 2 3 N LEU A 85  ? N LEU A 85  O TYR A 133 ? O TYR A 133 
AA1 3 4 O LEU A 130 ? O LEU A 130 N VAL A 119 ? N VAL A 119 
AA1 4 5 O THR A 120 ? O THR A 120 N GLU A 113 ? N GLU A 113 
AA2 1 2 N ILE A 145 ? N ILE A 145 O GLN A 160 ? O GLN A 160 
AA3 1 2 N ARG A 224 ? N ARG A 224 O THR A 233 ? O THR A 233 
AA4 1 2 N HIS A 252 ? N HIS A 252 O ARG A 265 ? O ARG A 265 
# 
_pdbx_entry_details.entry_id                   8YSJ 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 110 ? ? -88.52  33.18  
2 1 ASP A 163 ? ? -150.14 60.97  
3 1 VAL A 228 ? ? -109.87 -69.08 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 153 ? A GLY 153 
2  1 Y 1 A ASP 154 ? A ASP 154 
3  1 Y 1 A GLU 155 ? A GLU 155 
4  1 Y 1 A HIS 156 ? A HIS 156 
5  1 Y 1 A ASP 331 ? A ASP 331 
6  1 Y 1 A LYS 332 ? A LYS 332 
7  1 Y 1 A SER 333 ? A SER 333 
8  1 Y 1 A ALA 334 ? A ALA 334 
9  1 Y 1 A VAL 335 ? A VAL 335 
10 1 Y 1 A HIS 336 ? A HIS 336 
11 1 Y 1 A THR 337 ? A THR 337 
12 1 Y 1 A ALA 338 ? A ALA 338 
13 1 Y 1 A PRO 339 ? A PRO 339 
14 1 Y 1 A ALA 340 ? A ALA 340 
15 1 Y 1 A ILE 341 ? A ILE 341 
16 1 Y 1 A VAL 342 ? A VAL 342 
17 1 Y 1 A GLY 343 ? A GLY 343 
18 1 Y 1 A SER 344 ? A SER 344 
19 1 Y 1 A GLY 345 ? A GLY 345 
20 1 Y 1 A SER 346 ? A SER 346 
21 1 Y 1 A SER 347 ? A SER 347 
22 1 Y 1 A GLY 348 ? A GLY 348 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
2KH PA    P N N 1   
2KH O1A   O N N 2   
2KH O2A   O N N 3   
2KH N3A   N N N 4   
2KH "O5'" O N N 5   
2KH PB    P N N 6   
2KH O1B   O N N 7   
2KH O2B   O N N 8   
2KH O3B   O N N 9   
2KH PG    P N N 10  
2KH O1G   O N N 11  
2KH O2G   O N N 12  
2KH O3G   O N N 13  
2KH "C5'" C N N 14  
2KH "C4'" C N R 15  
2KH "O4'" O N N 16  
2KH "C1'" C N R 17  
2KH "C2'" C N R 18  
2KH "O2'" O N N 19  
2KH "C3'" C N S 20  
2KH "O3'" O N N 21  
2KH N1    N N N 22  
2KH C6    C N N 23  
2KH C2    C N N 24  
2KH O2    O N N 25  
2KH N3    N N N 26  
2KH C4    C N N 27  
2KH O4    O N N 28  
2KH C5    C N N 29  
2KH H1    H N N 30  
2KH H2    H N N 31  
2KH H3    H N N 32  
2KH H4    H N N 33  
2KH H5    H N N 34  
2KH H6    H N N 35  
2KH H7    H N N 36  
2KH H8    H N N 37  
2KH H9    H N N 38  
2KH H10   H N N 39  
2KH H11   H N N 40  
2KH H12   H N N 41  
2KH H13   H N N 42  
2KH H14   H N N 43  
2KH H15   H N N 44  
2KH H16   H N N 45  
ALA N     N N N 46  
ALA CA    C N S 47  
ALA C     C N N 48  
ALA O     O N N 49  
ALA CB    C N N 50  
ALA OXT   O N N 51  
ALA H     H N N 52  
ALA H2    H N N 53  
ALA HA    H N N 54  
ALA HB1   H N N 55  
ALA HB2   H N N 56  
ALA HB3   H N N 57  
ALA HXT   H N N 58  
ARG N     N N N 59  
ARG CA    C N S 60  
ARG C     C N N 61  
ARG O     O N N 62  
ARG CB    C N N 63  
ARG CG    C N N 64  
ARG CD    C N N 65  
ARG NE    N N N 66  
ARG CZ    C N N 67  
ARG NH1   N N N 68  
ARG NH2   N N N 69  
ARG OXT   O N N 70  
ARG H     H N N 71  
ARG H2    H N N 72  
ARG HA    H N N 73  
ARG HB2   H N N 74  
ARG HB3   H N N 75  
ARG HG2   H N N 76  
ARG HG3   H N N 77  
ARG HD2   H N N 78  
ARG HD3   H N N 79  
ARG HE    H N N 80  
ARG HH11  H N N 81  
ARG HH12  H N N 82  
ARG HH21  H N N 83  
ARG HH22  H N N 84  
ARG HXT   H N N 85  
ASN N     N N N 86  
ASN CA    C N S 87  
ASN C     C N N 88  
ASN O     O N N 89  
ASN CB    C N N 90  
ASN CG    C N N 91  
ASN OD1   O N N 92  
ASN ND2   N N N 93  
ASN OXT   O N N 94  
ASN H     H N N 95  
ASN H2    H N N 96  
ASN HA    H N N 97  
ASN HB2   H N N 98  
ASN HB3   H N N 99  
ASN HD21  H N N 100 
ASN HD22  H N N 101 
ASN HXT   H N N 102 
ASP N     N N N 103 
ASP CA    C N S 104 
ASP C     C N N 105 
ASP O     O N N 106 
ASP CB    C N N 107 
ASP CG    C N N 108 
ASP OD1   O N N 109 
ASP OD2   O N N 110 
ASP OXT   O N N 111 
ASP H     H N N 112 
ASP H2    H N N 113 
ASP HA    H N N 114 
ASP HB2   H N N 115 
ASP HB3   H N N 116 
ASP HD2   H N N 117 
ASP HXT   H N N 118 
CYS N     N N N 119 
CYS CA    C N R 120 
CYS C     C N N 121 
CYS O     O N N 122 
CYS CB    C N N 123 
CYS SG    S N N 124 
CYS OXT   O N N 125 
CYS H     H N N 126 
CYS H2    H N N 127 
CYS HA    H N N 128 
CYS HB2   H N N 129 
CYS HB3   H N N 130 
CYS HG    H N N 131 
CYS HXT   H N N 132 
GLN N     N N N 133 
GLN CA    C N S 134 
GLN C     C N N 135 
GLN O     O N N 136 
GLN CB    C N N 137 
GLN CG    C N N 138 
GLN CD    C N N 139 
GLN OE1   O N N 140 
GLN NE2   N N N 141 
GLN OXT   O N N 142 
GLN H     H N N 143 
GLN H2    H N N 144 
GLN HA    H N N 145 
GLN HB2   H N N 146 
GLN HB3   H N N 147 
GLN HG2   H N N 148 
GLN HG3   H N N 149 
GLN HE21  H N N 150 
GLN HE22  H N N 151 
GLN HXT   H N N 152 
GLU N     N N N 153 
GLU CA    C N S 154 
GLU C     C N N 155 
GLU O     O N N 156 
GLU CB    C N N 157 
GLU CG    C N N 158 
GLU CD    C N N 159 
GLU OE1   O N N 160 
GLU OE2   O N N 161 
GLU OXT   O N N 162 
GLU H     H N N 163 
GLU H2    H N N 164 
GLU HA    H N N 165 
GLU HB2   H N N 166 
GLU HB3   H N N 167 
GLU HG2   H N N 168 
GLU HG3   H N N 169 
GLU HE2   H N N 170 
GLU HXT   H N N 171 
GLY N     N N N 172 
GLY CA    C N N 173 
GLY C     C N N 174 
GLY O     O N N 175 
GLY OXT   O N N 176 
GLY H     H N N 177 
GLY H2    H N N 178 
GLY HA2   H N N 179 
GLY HA3   H N N 180 
GLY HXT   H N N 181 
HIS N     N N N 182 
HIS CA    C N S 183 
HIS C     C N N 184 
HIS O     O N N 185 
HIS CB    C N N 186 
HIS CG    C Y N 187 
HIS ND1   N Y N 188 
HIS CD2   C Y N 189 
HIS CE1   C Y N 190 
HIS NE2   N Y N 191 
HIS OXT   O N N 192 
HIS H     H N N 193 
HIS H2    H N N 194 
HIS HA    H N N 195 
HIS HB2   H N N 196 
HIS HB3   H N N 197 
HIS HD1   H N N 198 
HIS HD2   H N N 199 
HIS HE1   H N N 200 
HIS HE2   H N N 201 
HIS HXT   H N N 202 
HOH O     O N N 203 
HOH H1    H N N 204 
HOH H2    H N N 205 
ILE N     N N N 206 
ILE CA    C N S 207 
ILE C     C N N 208 
ILE O     O N N 209 
ILE CB    C N S 210 
ILE CG1   C N N 211 
ILE CG2   C N N 212 
ILE CD1   C N N 213 
ILE OXT   O N N 214 
ILE H     H N N 215 
ILE H2    H N N 216 
ILE HA    H N N 217 
ILE HB    H N N 218 
ILE HG12  H N N 219 
ILE HG13  H N N 220 
ILE HG21  H N N 221 
ILE HG22  H N N 222 
ILE HG23  H N N 223 
ILE HD11  H N N 224 
ILE HD12  H N N 225 
ILE HD13  H N N 226 
ILE HXT   H N N 227 
LEU N     N N N 228 
LEU CA    C N S 229 
LEU C     C N N 230 
LEU O     O N N 231 
LEU CB    C N N 232 
LEU CG    C N N 233 
LEU CD1   C N N 234 
LEU CD2   C N N 235 
LEU OXT   O N N 236 
LEU H     H N N 237 
LEU H2    H N N 238 
LEU HA    H N N 239 
LEU HB2   H N N 240 
LEU HB3   H N N 241 
LEU HG    H N N 242 
LEU HD11  H N N 243 
LEU HD12  H N N 244 
LEU HD13  H N N 245 
LEU HD21  H N N 246 
LEU HD22  H N N 247 
LEU HD23  H N N 248 
LEU HXT   H N N 249 
LYS N     N N N 250 
LYS CA    C N S 251 
LYS C     C N N 252 
LYS O     O N N 253 
LYS CB    C N N 254 
LYS CG    C N N 255 
LYS CD    C N N 256 
LYS CE    C N N 257 
LYS NZ    N N N 258 
LYS OXT   O N N 259 
LYS H     H N N 260 
LYS H2    H N N 261 
LYS HA    H N N 262 
LYS HB2   H N N 263 
LYS HB3   H N N 264 
LYS HG2   H N N 265 
LYS HG3   H N N 266 
LYS HD2   H N N 267 
LYS HD3   H N N 268 
LYS HE2   H N N 269 
LYS HE3   H N N 270 
LYS HZ1   H N N 271 
LYS HZ2   H N N 272 
LYS HZ3   H N N 273 
LYS HXT   H N N 274 
MET N     N N N 275 
MET CA    C N S 276 
MET C     C N N 277 
MET O     O N N 278 
MET CB    C N N 279 
MET CG    C N N 280 
MET SD    S N N 281 
MET CE    C N N 282 
MET OXT   O N N 283 
MET H     H N N 284 
MET H2    H N N 285 
MET HA    H N N 286 
MET HB2   H N N 287 
MET HB3   H N N 288 
MET HG2   H N N 289 
MET HG3   H N N 290 
MET HE1   H N N 291 
MET HE2   H N N 292 
MET HE3   H N N 293 
MET HXT   H N N 294 
PHE N     N N N 295 
PHE CA    C N S 296 
PHE C     C N N 297 
PHE O     O N N 298 
PHE CB    C N N 299 
PHE CG    C Y N 300 
PHE CD1   C Y N 301 
PHE CD2   C Y N 302 
PHE CE1   C Y N 303 
PHE CE2   C Y N 304 
PHE CZ    C Y N 305 
PHE OXT   O N N 306 
PHE H     H N N 307 
PHE H2    H N N 308 
PHE HA    H N N 309 
PHE HB2   H N N 310 
PHE HB3   H N N 311 
PHE HD1   H N N 312 
PHE HD2   H N N 313 
PHE HE1   H N N 314 
PHE HE2   H N N 315 
PHE HZ    H N N 316 
PHE HXT   H N N 317 
PRO N     N N N 318 
PRO CA    C N S 319 
PRO C     C N N 320 
PRO O     O N N 321 
PRO CB    C N N 322 
PRO CG    C N N 323 
PRO CD    C N N 324 
PRO OXT   O N N 325 
PRO H     H N N 326 
PRO HA    H N N 327 
PRO HB2   H N N 328 
PRO HB3   H N N 329 
PRO HG2   H N N 330 
PRO HG3   H N N 331 
PRO HD2   H N N 332 
PRO HD3   H N N 333 
PRO HXT   H N N 334 
SER N     N N N 335 
SER CA    C N S 336 
SER C     C N N 337 
SER O     O N N 338 
SER CB    C N N 339 
SER OG    O N N 340 
SER OXT   O N N 341 
SER H     H N N 342 
SER H2    H N N 343 
SER HA    H N N 344 
SER HB2   H N N 345 
SER HB3   H N N 346 
SER HG    H N N 347 
SER HXT   H N N 348 
THR N     N N N 349 
THR CA    C N S 350 
THR C     C N N 351 
THR O     O N N 352 
THR CB    C N R 353 
THR OG1   O N N 354 
THR CG2   C N N 355 
THR OXT   O N N 356 
THR H     H N N 357 
THR H2    H N N 358 
THR HA    H N N 359 
THR HB    H N N 360 
THR HG1   H N N 361 
THR HG21  H N N 362 
THR HG22  H N N 363 
THR HG23  H N N 364 
THR HXT   H N N 365 
TRP N     N N N 366 
TRP CA    C N S 367 
TRP C     C N N 368 
TRP O     O N N 369 
TRP CB    C N N 370 
TRP CG    C Y N 371 
TRP CD1   C Y N 372 
TRP CD2   C Y N 373 
TRP NE1   N Y N 374 
TRP CE2   C Y N 375 
TRP CE3   C Y N 376 
TRP CZ2   C Y N 377 
TRP CZ3   C Y N 378 
TRP CH2   C Y N 379 
TRP OXT   O N N 380 
TRP H     H N N 381 
TRP H2    H N N 382 
TRP HA    H N N 383 
TRP HB2   H N N 384 
TRP HB3   H N N 385 
TRP HD1   H N N 386 
TRP HE1   H N N 387 
TRP HE3   H N N 388 
TRP HZ2   H N N 389 
TRP HZ3   H N N 390 
TRP HH2   H N N 391 
TRP HXT   H N N 392 
TYR N     N N N 393 
TYR CA    C N S 394 
TYR C     C N N 395 
TYR O     O N N 396 
TYR CB    C N N 397 
TYR CG    C Y N 398 
TYR CD1   C Y N 399 
TYR CD2   C Y N 400 
TYR CE1   C Y N 401 
TYR CE2   C Y N 402 
TYR CZ    C Y N 403 
TYR OH    O N N 404 
TYR OXT   O N N 405 
TYR H     H N N 406 
TYR H2    H N N 407 
TYR HA    H N N 408 
TYR HB2   H N N 409 
TYR HB3   H N N 410 
TYR HD1   H N N 411 
TYR HD2   H N N 412 
TYR HE1   H N N 413 
TYR HE2   H N N 414 
TYR HH    H N N 415 
TYR HXT   H N N 416 
VAL N     N N N 417 
VAL CA    C N S 418 
VAL C     C N N 419 
VAL O     O N N 420 
VAL CB    C N N 421 
VAL CG1   C N N 422 
VAL CG2   C N N 423 
VAL OXT   O N N 424 
VAL H     H N N 425 
VAL H2    H N N 426 
VAL HA    H N N 427 
VAL HB    H N N 428 
VAL HG11  H N N 429 
VAL HG12  H N N 430 
VAL HG13  H N N 431 
VAL HG21  H N N 432 
VAL HG22  H N N 433 
VAL HG23  H N N 434 
VAL HXT   H N N 435 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
2KH "O2'" "C2'" sing N N 1   
2KH "O3'" "C3'" sing N N 2   
2KH "C2'" "C3'" sing N N 3   
2KH "C2'" "C1'" sing N N 4   
2KH O2    C2    doub N N 5   
2KH "C3'" "C4'" sing N N 6   
2KH "C1'" N1    sing N N 7   
2KH "C1'" "O4'" sing N N 8   
2KH C2    N1    sing N N 9   
2KH C2    N3    sing N N 10  
2KH "C4'" "O4'" sing N N 11  
2KH "C4'" "C5'" sing N N 12  
2KH N1    C6    sing N N 13  
2KH N3    C4    sing N N 14  
2KH "C5'" "O5'" sing N N 15  
2KH C6    C5    doub N N 16  
2KH C4    C5    sing N N 17  
2KH C4    O4    doub N N 18  
2KH O2B   PB    doub N N 19  
2KH "O5'" PA    sing N N 20  
2KH N3A   PB    sing N N 21  
2KH N3A   PA    sing N N 22  
2KH PB    O1B   sing N N 23  
2KH PB    O3B   sing N N 24  
2KH PA    O1A   doub N N 25  
2KH PA    O2A   sing N N 26  
2KH O3B   PG    sing N N 27  
2KH PG    O2G   doub N N 28  
2KH PG    O1G   sing N N 29  
2KH PG    O3G   sing N N 30  
2KH O2A   H1    sing N N 31  
2KH N3A   H2    sing N N 32  
2KH O1B   H3    sing N N 33  
2KH O1G   H4    sing N N 34  
2KH O3G   H5    sing N N 35  
2KH "C5'" H6    sing N N 36  
2KH "C5'" H7    sing N N 37  
2KH "C4'" H8    sing N N 38  
2KH "C1'" H9    sing N N 39  
2KH "C2'" H10   sing N N 40  
2KH "O2'" H11   sing N N 41  
2KH "C3'" H12   sing N N 42  
2KH "O3'" H13   sing N N 43  
2KH C6    H14   sing N N 44  
2KH N3    H15   sing N N 45  
2KH C5    H16   sing N N 46  
ALA N     CA    sing N N 47  
ALA N     H     sing N N 48  
ALA N     H2    sing N N 49  
ALA CA    C     sing N N 50  
ALA CA    CB    sing N N 51  
ALA CA    HA    sing N N 52  
ALA C     O     doub N N 53  
ALA C     OXT   sing N N 54  
ALA CB    HB1   sing N N 55  
ALA CB    HB2   sing N N 56  
ALA CB    HB3   sing N N 57  
ALA OXT   HXT   sing N N 58  
ARG N     CA    sing N N 59  
ARG N     H     sing N N 60  
ARG N     H2    sing N N 61  
ARG CA    C     sing N N 62  
ARG CA    CB    sing N N 63  
ARG CA    HA    sing N N 64  
ARG C     O     doub N N 65  
ARG C     OXT   sing N N 66  
ARG CB    CG    sing N N 67  
ARG CB    HB2   sing N N 68  
ARG CB    HB3   sing N N 69  
ARG CG    CD    sing N N 70  
ARG CG    HG2   sing N N 71  
ARG CG    HG3   sing N N 72  
ARG CD    NE    sing N N 73  
ARG CD    HD2   sing N N 74  
ARG CD    HD3   sing N N 75  
ARG NE    CZ    sing N N 76  
ARG NE    HE    sing N N 77  
ARG CZ    NH1   sing N N 78  
ARG CZ    NH2   doub N N 79  
ARG NH1   HH11  sing N N 80  
ARG NH1   HH12  sing N N 81  
ARG NH2   HH21  sing N N 82  
ARG NH2   HH22  sing N N 83  
ARG OXT   HXT   sing N N 84  
ASN N     CA    sing N N 85  
ASN N     H     sing N N 86  
ASN N     H2    sing N N 87  
ASN CA    C     sing N N 88  
ASN CA    CB    sing N N 89  
ASN CA    HA    sing N N 90  
ASN C     O     doub N N 91  
ASN C     OXT   sing N N 92  
ASN CB    CG    sing N N 93  
ASN CB    HB2   sing N N 94  
ASN CB    HB3   sing N N 95  
ASN CG    OD1   doub N N 96  
ASN CG    ND2   sing N N 97  
ASN ND2   HD21  sing N N 98  
ASN ND2   HD22  sing N N 99  
ASN OXT   HXT   sing N N 100 
ASP N     CA    sing N N 101 
ASP N     H     sing N N 102 
ASP N     H2    sing N N 103 
ASP CA    C     sing N N 104 
ASP CA    CB    sing N N 105 
ASP CA    HA    sing N N 106 
ASP C     O     doub N N 107 
ASP C     OXT   sing N N 108 
ASP CB    CG    sing N N 109 
ASP CB    HB2   sing N N 110 
ASP CB    HB3   sing N N 111 
ASP CG    OD1   doub N N 112 
ASP CG    OD2   sing N N 113 
ASP OD2   HD2   sing N N 114 
ASP OXT   HXT   sing N N 115 
CYS N     CA    sing N N 116 
CYS N     H     sing N N 117 
CYS N     H2    sing N N 118 
CYS CA    C     sing N N 119 
CYS CA    CB    sing N N 120 
CYS CA    HA    sing N N 121 
CYS C     O     doub N N 122 
CYS C     OXT   sing N N 123 
CYS CB    SG    sing N N 124 
CYS CB    HB2   sing N N 125 
CYS CB    HB3   sing N N 126 
CYS SG    HG    sing N N 127 
CYS OXT   HXT   sing N N 128 
GLN N     CA    sing N N 129 
GLN N     H     sing N N 130 
GLN N     H2    sing N N 131 
GLN CA    C     sing N N 132 
GLN CA    CB    sing N N 133 
GLN CA    HA    sing N N 134 
GLN C     O     doub N N 135 
GLN C     OXT   sing N N 136 
GLN CB    CG    sing N N 137 
GLN CB    HB2   sing N N 138 
GLN CB    HB3   sing N N 139 
GLN CG    CD    sing N N 140 
GLN CG    HG2   sing N N 141 
GLN CG    HG3   sing N N 142 
GLN CD    OE1   doub N N 143 
GLN CD    NE2   sing N N 144 
GLN NE2   HE21  sing N N 145 
GLN NE2   HE22  sing N N 146 
GLN OXT   HXT   sing N N 147 
GLU N     CA    sing N N 148 
GLU N     H     sing N N 149 
GLU N     H2    sing N N 150 
GLU CA    C     sing N N 151 
GLU CA    CB    sing N N 152 
GLU CA    HA    sing N N 153 
GLU C     O     doub N N 154 
GLU C     OXT   sing N N 155 
GLU CB    CG    sing N N 156 
GLU CB    HB2   sing N N 157 
GLU CB    HB3   sing N N 158 
GLU CG    CD    sing N N 159 
GLU CG    HG2   sing N N 160 
GLU CG    HG3   sing N N 161 
GLU CD    OE1   doub N N 162 
GLU CD    OE2   sing N N 163 
GLU OE2   HE2   sing N N 164 
GLU OXT   HXT   sing N N 165 
GLY N     CA    sing N N 166 
GLY N     H     sing N N 167 
GLY N     H2    sing N N 168 
GLY CA    C     sing N N 169 
GLY CA    HA2   sing N N 170 
GLY CA    HA3   sing N N 171 
GLY C     O     doub N N 172 
GLY C     OXT   sing N N 173 
GLY OXT   HXT   sing N N 174 
HIS N     CA    sing N N 175 
HIS N     H     sing N N 176 
HIS N     H2    sing N N 177 
HIS CA    C     sing N N 178 
HIS CA    CB    sing N N 179 
HIS CA    HA    sing N N 180 
HIS C     O     doub N N 181 
HIS C     OXT   sing N N 182 
HIS CB    CG    sing N N 183 
HIS CB    HB2   sing N N 184 
HIS CB    HB3   sing N N 185 
HIS CG    ND1   sing Y N 186 
HIS CG    CD2   doub Y N 187 
HIS ND1   CE1   doub Y N 188 
HIS ND1   HD1   sing N N 189 
HIS CD2   NE2   sing Y N 190 
HIS CD2   HD2   sing N N 191 
HIS CE1   NE2   sing Y N 192 
HIS CE1   HE1   sing N N 193 
HIS NE2   HE2   sing N N 194 
HIS OXT   HXT   sing N N 195 
HOH O     H1    sing N N 196 
HOH O     H2    sing N N 197 
ILE N     CA    sing N N 198 
ILE N     H     sing N N 199 
ILE N     H2    sing N N 200 
ILE CA    C     sing N N 201 
ILE CA    CB    sing N N 202 
ILE CA    HA    sing N N 203 
ILE C     O     doub N N 204 
ILE C     OXT   sing N N 205 
ILE CB    CG1   sing N N 206 
ILE CB    CG2   sing N N 207 
ILE CB    HB    sing N N 208 
ILE CG1   CD1   sing N N 209 
ILE CG1   HG12  sing N N 210 
ILE CG1   HG13  sing N N 211 
ILE CG2   HG21  sing N N 212 
ILE CG2   HG22  sing N N 213 
ILE CG2   HG23  sing N N 214 
ILE CD1   HD11  sing N N 215 
ILE CD1   HD12  sing N N 216 
ILE CD1   HD13  sing N N 217 
ILE OXT   HXT   sing N N 218 
LEU N     CA    sing N N 219 
LEU N     H     sing N N 220 
LEU N     H2    sing N N 221 
LEU CA    C     sing N N 222 
LEU CA    CB    sing N N 223 
LEU CA    HA    sing N N 224 
LEU C     O     doub N N 225 
LEU C     OXT   sing N N 226 
LEU CB    CG    sing N N 227 
LEU CB    HB2   sing N N 228 
LEU CB    HB3   sing N N 229 
LEU CG    CD1   sing N N 230 
LEU CG    CD2   sing N N 231 
LEU CG    HG    sing N N 232 
LEU CD1   HD11  sing N N 233 
LEU CD1   HD12  sing N N 234 
LEU CD1   HD13  sing N N 235 
LEU CD2   HD21  sing N N 236 
LEU CD2   HD22  sing N N 237 
LEU CD2   HD23  sing N N 238 
LEU OXT   HXT   sing N N 239 
LYS N     CA    sing N N 240 
LYS N     H     sing N N 241 
LYS N     H2    sing N N 242 
LYS CA    C     sing N N 243 
LYS CA    CB    sing N N 244 
LYS CA    HA    sing N N 245 
LYS C     O     doub N N 246 
LYS C     OXT   sing N N 247 
LYS CB    CG    sing N N 248 
LYS CB    HB2   sing N N 249 
LYS CB    HB3   sing N N 250 
LYS CG    CD    sing N N 251 
LYS CG    HG2   sing N N 252 
LYS CG    HG3   sing N N 253 
LYS CD    CE    sing N N 254 
LYS CD    HD2   sing N N 255 
LYS CD    HD3   sing N N 256 
LYS CE    NZ    sing N N 257 
LYS CE    HE2   sing N N 258 
LYS CE    HE3   sing N N 259 
LYS NZ    HZ1   sing N N 260 
LYS NZ    HZ2   sing N N 261 
LYS NZ    HZ3   sing N N 262 
LYS OXT   HXT   sing N N 263 
MET N     CA    sing N N 264 
MET N     H     sing N N 265 
MET N     H2    sing N N 266 
MET CA    C     sing N N 267 
MET CA    CB    sing N N 268 
MET CA    HA    sing N N 269 
MET C     O     doub N N 270 
MET C     OXT   sing N N 271 
MET CB    CG    sing N N 272 
MET CB    HB2   sing N N 273 
MET CB    HB3   sing N N 274 
MET CG    SD    sing N N 275 
MET CG    HG2   sing N N 276 
MET CG    HG3   sing N N 277 
MET SD    CE    sing N N 278 
MET CE    HE1   sing N N 279 
MET CE    HE2   sing N N 280 
MET CE    HE3   sing N N 281 
MET OXT   HXT   sing N N 282 
PHE N     CA    sing N N 283 
PHE N     H     sing N N 284 
PHE N     H2    sing N N 285 
PHE CA    C     sing N N 286 
PHE CA    CB    sing N N 287 
PHE CA    HA    sing N N 288 
PHE C     O     doub N N 289 
PHE C     OXT   sing N N 290 
PHE CB    CG    sing N N 291 
PHE CB    HB2   sing N N 292 
PHE CB    HB3   sing N N 293 
PHE CG    CD1   doub Y N 294 
PHE CG    CD2   sing Y N 295 
PHE CD1   CE1   sing Y N 296 
PHE CD1   HD1   sing N N 297 
PHE CD2   CE2   doub Y N 298 
PHE CD2   HD2   sing N N 299 
PHE CE1   CZ    doub Y N 300 
PHE CE1   HE1   sing N N 301 
PHE CE2   CZ    sing Y N 302 
PHE CE2   HE2   sing N N 303 
PHE CZ    HZ    sing N N 304 
PHE OXT   HXT   sing N N 305 
PRO N     CA    sing N N 306 
PRO N     CD    sing N N 307 
PRO N     H     sing N N 308 
PRO CA    C     sing N N 309 
PRO CA    CB    sing N N 310 
PRO CA    HA    sing N N 311 
PRO C     O     doub N N 312 
PRO C     OXT   sing N N 313 
PRO CB    CG    sing N N 314 
PRO CB    HB2   sing N N 315 
PRO CB    HB3   sing N N 316 
PRO CG    CD    sing N N 317 
PRO CG    HG2   sing N N 318 
PRO CG    HG3   sing N N 319 
PRO CD    HD2   sing N N 320 
PRO CD    HD3   sing N N 321 
PRO OXT   HXT   sing N N 322 
SER N     CA    sing N N 323 
SER N     H     sing N N 324 
SER N     H2    sing N N 325 
SER CA    C     sing N N 326 
SER CA    CB    sing N N 327 
SER CA    HA    sing N N 328 
SER C     O     doub N N 329 
SER C     OXT   sing N N 330 
SER CB    OG    sing N N 331 
SER CB    HB2   sing N N 332 
SER CB    HB3   sing N N 333 
SER OG    HG    sing N N 334 
SER OXT   HXT   sing N N 335 
THR N     CA    sing N N 336 
THR N     H     sing N N 337 
THR N     H2    sing N N 338 
THR CA    C     sing N N 339 
THR CA    CB    sing N N 340 
THR CA    HA    sing N N 341 
THR C     O     doub N N 342 
THR C     OXT   sing N N 343 
THR CB    OG1   sing N N 344 
THR CB    CG2   sing N N 345 
THR CB    HB    sing N N 346 
THR OG1   HG1   sing N N 347 
THR CG2   HG21  sing N N 348 
THR CG2   HG22  sing N N 349 
THR CG2   HG23  sing N N 350 
THR OXT   HXT   sing N N 351 
TRP N     CA    sing N N 352 
TRP N     H     sing N N 353 
TRP N     H2    sing N N 354 
TRP CA    C     sing N N 355 
TRP CA    CB    sing N N 356 
TRP CA    HA    sing N N 357 
TRP C     O     doub N N 358 
TRP C     OXT   sing N N 359 
TRP CB    CG    sing N N 360 
TRP CB    HB2   sing N N 361 
TRP CB    HB3   sing N N 362 
TRP CG    CD1   doub Y N 363 
TRP CG    CD2   sing Y N 364 
TRP CD1   NE1   sing Y N 365 
TRP CD1   HD1   sing N N 366 
TRP CD2   CE2   doub Y N 367 
TRP CD2   CE3   sing Y N 368 
TRP NE1   CE2   sing Y N 369 
TRP NE1   HE1   sing N N 370 
TRP CE2   CZ2   sing Y N 371 
TRP CE3   CZ3   doub Y N 372 
TRP CE3   HE3   sing N N 373 
TRP CZ2   CH2   doub Y N 374 
TRP CZ2   HZ2   sing N N 375 
TRP CZ3   CH2   sing Y N 376 
TRP CZ3   HZ3   sing N N 377 
TRP CH2   HH2   sing N N 378 
TRP OXT   HXT   sing N N 379 
TYR N     CA    sing N N 380 
TYR N     H     sing N N 381 
TYR N     H2    sing N N 382 
TYR CA    C     sing N N 383 
TYR CA    CB    sing N N 384 
TYR CA    HA    sing N N 385 
TYR C     O     doub N N 386 
TYR C     OXT   sing N N 387 
TYR CB    CG    sing N N 388 
TYR CB    HB2   sing N N 389 
TYR CB    HB3   sing N N 390 
TYR CG    CD1   doub Y N 391 
TYR CG    CD2   sing Y N 392 
TYR CD1   CE1   sing Y N 393 
TYR CD1   HD1   sing N N 394 
TYR CD2   CE2   doub Y N 395 
TYR CD2   HD2   sing N N 396 
TYR CE1   CZ    doub Y N 397 
TYR CE1   HE1   sing N N 398 
TYR CE2   CZ    sing Y N 399 
TYR CE2   HE2   sing N N 400 
TYR CZ    OH    sing N N 401 
TYR OH    HH    sing N N 402 
TYR OXT   HXT   sing N N 403 
VAL N     CA    sing N N 404 
VAL N     H     sing N N 405 
VAL N     H2    sing N N 406 
VAL CA    C     sing N N 407 
VAL CA    CB    sing N N 408 
VAL CA    HA    sing N N 409 
VAL C     O     doub N N 410 
VAL C     OXT   sing N N 411 
VAL CB    CG1   sing N N 412 
VAL CB    CG2   sing N N 413 
VAL CB    HB    sing N N 414 
VAL CG1   HG11  sing N N 415 
VAL CG1   HG12  sing N N 416 
VAL CG1   HG13  sing N N 417 
VAL CG2   HG21  sing N N 418 
VAL CG2   HG22  sing N N 419 
VAL CG2   HG23  sing N N 420 
VAL OXT   HXT   sing N N 421 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           111-2311-B-039-001-MY3 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'apo DwCdnB' 
# 
_atom_sites.entry_id                    8YSJ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028292 
_atom_sites.fract_transf_matrix[1][2]   -0.002838 
_atom_sites.fract_transf_matrix[1][3]   -0.008129 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.021733 
_atom_sites.fract_transf_matrix[2][3]   -0.005661 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.017686 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C   6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865   51.651 0.216   
H   1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041   57.800 0.003   
N   7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167   0.583  -11.538 
O   8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867   32.909 0.251   
O-1 8  9  4.195  12.857 1.641 4.172  1.528 47.018 -20.325 -0.014 21.960  
P   15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491   68.164 1.115   
S   16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586   56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N     . MET A 1 1   ? 2.346   17.733  -25.163 1.000 30.529  0  1   MET A N     1 ? 
ATOM   2    C CA    . MET A 1 1   ? 1.856   17.060  -23.891 1.000 31.673  0  1   MET A CA    1 ? 
ATOM   3    C C     . MET A 1 1   ? 0.630   16.187  -24.197 1.000 25.786  0  1   MET A C     1 ? 
ATOM   4    O O     . MET A 1 1   ? -0.244  16.607  -24.945 1.000 23.516  0  1   MET A O     1 ? 
ATOM   5    C CB    . MET A 1 1   ? 1.513   18.070  -22.791 1.000 36.412  0  1   MET A CB    1 ? 
ATOM   6    C CG    . MET A 1 1   ? 1.856   17.544  -21.395 1.000 47.296  0  1   MET A CG    1 ? 
ATOM   7    S SD    . MET A 1 1   ? 1.418   18.684  -20.063 1.000 53.897  0  1   MET A SD    1 ? 
ATOM   8    C CE    . MET A 1 1   ? 2.538   20.027  -20.445 1.000 55.666  0  1   MET A CE    1 ? 
ATOM   9    N N     . ALA A 1 2   ? 0.616   14.984  -23.647 1.000 23.890  0  2   ALA A N     1 ? 
ATOM   10   C CA    . ALA A 1 2   ? -0.422  13.944  -23.828 1.000 24.862  0  2   ALA A CA    1 ? 
ATOM   11   C C     . ALA A 1 2   ? -1.773  14.474  -23.386 1.000 25.685  0  2   ALA A C     1 ? 
ATOM   12   O O     . ALA A 1 2   ? -1.869  15.332  -22.496 1.000 22.619  0  2   ALA A O     1 ? 
ATOM   13   C CB    . ALA A 1 2   ? -0.017  12.717  -23.043 1.000 26.765  0  2   ALA A CB    1 ? 
ATOM   14   N N     . PRO A 1 3   ? -2.871  13.938  -23.965 1.000 29.666  0  3   PRO A N     1 ? 
ATOM   15   C CA    . PRO A 1 3   ? -4.216  14.296  -23.521 1.000 26.916  0  3   PRO A CA    1 ? 
ATOM   16   C C     . PRO A 1 3   ? -4.366  14.004  -22.013 1.000 22.776  0  3   PRO A C     1 ? 
ATOM   17   O O     . PRO A 1 3   ? -3.814  12.959  -21.592 1.000 18.900  0  3   PRO A O     1 ? 
ATOM   18   C CB    . PRO A 1 3   ? -5.136  13.387  -24.363 1.000 30.355  0  3   PRO A CB    1 ? 
ATOM   19   C CG    . PRO A 1 3   ? -4.282  12.976  -25.580 1.000 32.508  0  3   PRO A CG    1 ? 
ATOM   20   C CD    . PRO A 1 3   ? -2.868  12.934  -25.050 1.000 31.986  0  3   PRO A CD    1 ? 
ATOM   21   N N     . VAL A 1 4   ? -4.975  14.957  -21.269 1.000 17.734  0  4   VAL A N     1 ? 
ATOM   22   C CA    . VAL A 1 4   ? -5.351  14.914  -19.815 1.000 17.151  0  4   VAL A CA    1 ? 
ATOM   23   C C     . VAL A 1 4   ? -4.119  14.805  -18.904 1.000 14.106  0  4   VAL A C     1 ? 
ATOM   24   O O     . VAL A 1 4   ? -4.286  14.692  -17.655 1.000 12.405  0  4   VAL A O     1 ? 
ATOM   25   C CB    . VAL A 1 4   ? -6.391  13.813  -19.538 1.000 20.361  0  4   VAL A CB    1 ? 
ATOM   26   C CG1   . VAL A 1 4   ? -7.540  13.911  -20.548 1.000 23.033  0  4   VAL A CG1   1 ? 
ATOM   27   C CG2   . VAL A 1 4   ? -5.800  12.440  -19.567 1.000 24.074  0  4   VAL A CG2   1 ? 
ATOM   28   N N     . GLN A 1 5   ? -2.913  14.893  -19.452 1.000 12.872  0  5   GLN A N     1 ? 
ATOM   29   C CA    . GLN A 1 5   ? -1.707  14.803  -18.603 1.000 12.635  0  5   GLN A CA    1 ? 
ATOM   30   C C     . GLN A 1 5   ? -1.708  15.913  -17.530 1.000 11.583  0  5   GLN A C     1 ? 
ATOM   31   O O     . GLN A 1 5   ? -1.359  15.627  -16.388 1.000 11.953  0  5   GLN A O     1 ? 
ATOM   32   C CB    . GLN A 1 5   ? -0.452  14.874  -19.442 1.000 12.765  0  5   GLN A CB    1 ? 
ATOM   33   C CG    . GLN A 1 5   ? 0.810   14.620  -18.634 1.000 12.299  0  5   GLN A CG    1 ? 
ATOM   34   C CD    . GLN A 1 5   ? 0.897   13.266  -17.971 1.000 13.002  0  5   GLN A CD    1 ? 
ATOM   35   O OE1   . GLN A 1 5   ? 0.099   12.348  -18.207 1.000 12.190  0  5   GLN A OE1   1 ? 
ATOM   36   N NE2   . GLN A 1 5   ? 1.949   13.097  -17.184 1.000 12.427  0  5   GLN A NE2   1 ? 
ATOM   37   N N     . LYS A 1 6   ? -2.071  17.137  -17.883 1.000 11.678  0  6   LYS A N     1 ? 
ATOM   38   C CA    . LYS A 1 6   ? -2.002  18.262  -16.943 1.000 13.068  0  6   LYS A CA    1 ? 
ATOM   39   C C     . LYS A 1 6   ? -2.910  17.974  -15.754 1.000 11.668  0  6   LYS A C     1 ? 
ATOM   40   O O     . LYS A 1 6   ? -2.468  18.125  -14.602 1.000 11.305  0  6   LYS A O     1 ? 
ATOM   41   C CB    . LYS A 1 6   ? -2.354  19.581  -17.618 1.000 14.841  0  6   LYS A CB    1 ? 
ATOM   42   C CG    . LYS A 1 6   ? -2.340  20.765  -16.650 1.000 16.667  0  6   LYS A CG    1 ? 
ATOM   43   C CD    . LYS A 1 6   ? -2.710  22.048  -17.320 1.000 21.385  0  6   LYS A CD    1 ? 
ATOM   44   C CE    . LYS A 1 6   ? -2.823  23.201  -16.351 1.000 24.614  0  6   LYS A CE    1 ? 
ATOM   45   N NZ    . LYS A 1 6   ? -4.176  23.252  -15.760 1.000 25.438  0  6   LYS A NZ    1 ? 
ATOM   46   N N     . GLN A 1 7   ? -4.094  17.426  -16.020 1.000 11.855  0  7   GLN A N     1 ? 
ATOM   47   C CA    . GLN A 1 7   ? -5.102  17.126  -14.981 1.000 11.812  0  7   GLN A CA    1 ? 
ATOM   48   C C     . GLN A 1 7   ? -4.664  15.914  -14.156 1.000 11.427  0  7   GLN A C     1 ? 
ATOM   49   O O     . GLN A 1 7   ? -4.885  15.958  -12.941 1.000 11.850  0  7   GLN A O     1 ? 
ATOM   50   C CB    . GLN A 1 7   ? -6.479  16.968  -15.604 1.000 12.663  0  7   GLN A CB    1 ? 
ATOM   51   C CG    . GLN A 1 7   ? -7.059  18.287  -16.142 1.000 13.032  0  7   GLN A CG    1 ? 
ATOM   52   C CD    . GLN A 1 7   ? -6.410  18.795  -17.392 1.000 13.160  0  7   GLN A CD    1 ? 
ATOM   53   O OE1   . GLN A 1 7   ? -6.050  18.045  -18.273 1.000 13.447  0  7   GLN A OE1   1 ? 
ATOM   54   N NE2   . GLN A 1 7   ? -6.207  20.096  -17.452 1.000 13.832  0  7   GLN A NE2   1 ? 
ATOM   55   N N     . PHE A 1 8   ? -4.049  14.885  -14.748 1.000 10.187  0  8   PHE A N     1 ? 
ATOM   56   C CA    . PHE A 1 8   ? -3.442  13.804  -13.937 1.000 10.087  0  8   PHE A CA    1 ? 
ATOM   57   C C     . PHE A 1 8   ? -2.439  14.404  -12.960 1.000 9.908   0  8   PHE A C     1 ? 
ATOM   58   O O     . PHE A 1 8   ? -2.437  13.984  -11.810 1.000 10.034  0  8   PHE A O     1 ? 
ATOM   59   C CB    . PHE A 1 8   ? -2.853  12.683  -14.789 1.000 10.455  0  8   PHE A CB    1 ? 
ATOM   60   C CG    . PHE A 1 8   ? -3.842  11.587  -15.053 1.000 10.915  0  8   PHE A CG    1 ? 
ATOM   61   C CD1   . PHE A 1 8   ? -4.204  10.712  -14.042 1.000 11.523  0  8   PHE A CD1   1 ? 
ATOM   62   C CD2   . PHE A 1 8   ? -4.426  11.444  -16.287 1.000 10.615  0  8   PHE A CD2   1 ? 
ATOM   63   C CE1   . PHE A 1 8   ? -5.076  9.658   -14.284 1.000 11.046  0  8   PHE A CE1   1 ? 
ATOM   64   C CE2   . PHE A 1 8   ? -5.356  10.430  -16.507 1.000 12.483  0  8   PHE A CE2   1 ? 
ATOM   65   C CZ    . PHE A 1 8   ? -5.692  9.556   -15.505 1.000 11.421  0  8   PHE A CZ    1 ? 
ATOM   66   N N     . ARG A 1 9   ? -1.544  15.280  -13.408 1.000 10.840  0  9   ARG A N     1 ? 
ATOM   67   C CA    . ARG A 1 9   ? -0.470  15.792  -12.525 1.000 10.563  0  9   ARG A CA    1 ? 
ATOM   68   C C     . ARG A 1 9   ? -1.087  16.655  -11.414 1.000 10.627  0  9   ARG A C     1 ? 
ATOM   69   O O     . ARG A 1 9   ? -0.600  16.563  -10.282 1.000 11.996  0  9   ARG A O     1 ? 
ATOM   70   C CB    . ARG A 1 9   ? 0.615   16.534  -13.290 1.000 10.633  0  9   ARG A CB    1 ? 
ATOM   71   C CG    . ARG A 1 9   ? 1.382   15.681  -14.265 1.000 11.280  0  9   ARG A CG    1 ? 
ATOM   72   C CD    . ARG A 1 9   ? 2.163   14.543  -13.672 1.000 12.091  0  9   ARG A CD    1 ? 
ATOM   73   N NE    . ARG A 1 9   ? 3.135   14.941  -12.675 1.000 13.172  0  9   ARG A NE    1 ? 
ATOM   74   C CZ    . ARG A 1 9   ? 4.417   15.189  -12.908 1.000 14.258  0  9   ARG A CZ    1 ? 
ATOM   75   N NH1   . ARG A 1 9   ? 4.897   15.177  -14.135 1.000 15.480  0  9   ARG A NH1   1 ? 
ATOM   76   N NH2   . ARG A 1 9   ? 5.210   15.493  -11.896 1.000 15.235  0  9   ARG A NH2   1 ? 
ATOM   77   N N     . GLU A 1 10  ? -2.138  17.412  -11.701 1.000 11.126  0  10  GLU A N     1 ? 
ATOM   78   C CA    . GLU A 1 10  ? -2.847  18.241  -10.694 1.000 12.437  0  10  GLU A CA    1 ? 
ATOM   79   C C     . GLU A 1 10  ? -3.551  17.321  -9.696  1.000 11.691  0  10  GLU A C     1 ? 
ATOM   80   O O     . GLU A 1 10  ? -3.532  17.619  -8.527  1.000 11.023  0  10  GLU A O     1 ? 
ATOM   81   C CB    . GLU A 1 10  ? -3.852  19.162  -11.384 1.000 13.790  0  10  GLU A CB    1 ? 
ATOM   82   C CG    . GLU A 1 10  ? -3.201  20.325  -12.111 1.000 16.516  0  10  GLU A CG    1 ? 
ATOM   83   C CD    . GLU A 1 10  ? -4.132  21.132  -13.015 1.000 20.725  0  10  GLU A CD    1 ? 
ATOM   84   O OE1   . GLU A 1 10  ? -5.281  20.683  -13.272 1.000 20.148  0  10  GLU A OE1   1 ? 
ATOM   85   O OE2   . GLU A 1 10  ? -3.654  22.112  -13.581 1.000 27.955  0  10  GLU A OE2   1 ? 
ATOM   86   N N     . PHE A 1 11  ? -4.142  16.215  -10.170 1.000 10.562  0  11  PHE A N     1 ? 
ATOM   87   C CA    . PHE A 1 11  ? -4.779  15.196  -9.297  1.000 10.148  0  11  PHE A CA    1 ? 
ATOM   88   C C     . PHE A 1 11  ? -3.709  14.622  -8.371  1.000 10.049  0  11  PHE A C     1 ? 
ATOM   89   O O     . PHE A 1 11  ? -3.914  14.517  -7.137  1.000 9.589   0  11  PHE A O     1 ? 
ATOM   90   C CB    . PHE A 1 11  ? -5.436  14.125  -10.167 1.000 10.132  0  11  PHE A CB    1 ? 
ATOM   91   C CG    . PHE A 1 11  ? -6.011  12.958  -9.430  1.000 10.253  0  11  PHE A CG    1 ? 
ATOM   92   C CD1   . PHE A 1 11  ? -6.919  13.139  -8.387  1.000 10.762  0  11  PHE A CD1   1 ? 
ATOM   93   C CD2   . PHE A 1 11  ? -5.678  11.660  -9.799  1.000 10.794  0  11  PHE A CD2   1 ? 
ATOM   94   C CE1   . PHE A 1 11  ? -7.460  12.038  -7.729  1.000 9.842   0  11  PHE A CE1   1 ? 
ATOM   95   C CE2   . PHE A 1 11  ? -6.237  10.569  -9.140  1.000 9.927   0  11  PHE A CE2   1 ? 
ATOM   96   C CZ    . PHE A 1 11  ? -7.114  10.756  -8.099  1.000 9.952   0  11  PHE A CZ    1 ? 
ATOM   97   N N     . HIS A 1 12  ? -2.563  14.261  -8.944  1.000 9.895   0  12  HIS A N     1 ? 
ATOM   98   C CA    . HIS A 1 12  ? -1.420  13.693  -8.172  1.000 10.532  0  12  HIS A CA    1 ? 
ATOM   99   C C     . HIS A 1 12  ? -0.996  14.658  -7.059  1.000 11.764  0  12  HIS A C     1 ? 
ATOM   100  O O     . HIS A 1 12  ? -0.819  14.210  -5.893  1.000 11.043  0  12  HIS A O     1 ? 
ATOM   101  C CB    . HIS A 1 12  ? -0.231  13.365  -9.085  1.000 11.150  0  12  HIS A CB    1 ? 
ATOM   102  C CG    . HIS A 1 12  ? 0.824   12.640  -8.326  1.000 10.350  0  12  HIS A CG    1 ? 
ATOM   103  N ND1   . HIS A 1 12  ? 2.006   13.244  -7.991  1.000 11.751  0  12  HIS A ND1   1 ? 
ATOM   104  C CD2   . HIS A 1 12  ? 0.824   11.419  -7.748  1.000 10.810  0  12  HIS A CD2   1 ? 
ATOM   105  C CE1   . HIS A 1 12  ? 2.712   12.412  -7.220  1.000 11.160  0  12  HIS A CE1   1 ? 
ATOM   106  N NE2   . HIS A 1 12  ? 2.008   11.273  -7.081  1.000 11.507  0  12  HIS A NE2   1 ? 
ATOM   107  N N     . ASP A 1 13  ? -0.829  15.932  -7.399  1.000 12.446  0  13  ASP A N     1 ? 
ATOM   108  C CA    . ASP A 1 13  ? -0.473  17.007  -6.434  1.000 14.833  0  13  ASP A CA    1 ? 
ATOM   109  C C     . ASP A 1 13  ? -1.454  17.028  -5.267  1.000 13.753  0  13  ASP A C     1 ? 
ATOM   110  O O     . ASP A 1 13  ? -1.010  17.245  -4.130  1.000 14.587  0  13  ASP A O     1 ? 
ATOM   111  C CB    . ASP A 1 13  ? -0.475  18.369  -7.101  1.000 16.676  0  13  ASP A CB    1 ? 
ATOM   112  C CG    . ASP A 1 13  ? 0.671   18.599  -8.074  1.000 20.220  0  13  ASP A CG    1 ? 
ATOM   113  O OD1   . ASP A 1 13  ? 1.668   17.872  -8.003  1.000 18.796  0  13  ASP A OD1   1 ? 
ATOM   114  O OD2   . ASP A 1 13  ? 0.513   19.470  -8.926  1.000 22.628  0  13  ASP A OD2   1 ? 
ATOM   115  N N     . ARG A 1 14  ? -2.734  16.805  -5.527  1.000 12.714  0  14  ARG A N     1 ? 
ATOM   116  C CA    . ARG A 1 14  ? -3.793  16.874  -4.498  1.000 13.203  0  14  ARG A CA    1 ? 
ATOM   117  C C     . ARG A 1 14  ? -3.823  15.629  -3.614  1.000 12.730  0  14  ARG A C     1 ? 
ATOM   118  O O     . ARG A 1 14  ? -4.419  15.730  -2.554  1.000 12.964  0  14  ARG A O     1 ? 
ATOM   119  C CB    . ARG A 1 14  ? -5.151  17.102  -5.155  1.000 15.089  0  14  ARG A CB    1 ? 
ATOM   120  C CG    . ARG A 1 14  ? -5.320  18.534  -5.656  1.000 15.166  0  14  ARG A CG    1 ? 
ATOM   121  C CD    . ARG A 1 14  ? -6.280  18.738  -6.843  1.000 16.575  0  14  ARG A CD    1 ? 
ATOM   122  N NE    . ARG A 1 14  ? -6.421  20.167  -7.087  1.000 17.078  0  14  ARG A NE    1 ? 
ATOM   123  C CZ    . ARG A 1 14  ? -5.520  20.920  -7.730  1.000 18.611  0  14  ARG A CZ    1 ? 
ATOM   124  N NH1   . ARG A 1 14  ? -5.692  22.233  -7.794  1.000 17.438  0  14  ARG A NH1   1 ? 
ATOM   125  N NH2   . ARG A 1 14  ? -4.422  20.377  -8.246  1.000 17.143  0  14  ARG A NH2   1 ? 
ATOM   126  N N     . ILE A 1 15  ? -3.403  14.448  -4.100  1.000 12.111  0  15  ILE A N     1 ? 
ATOM   127  C CA    . ILE A 1 15  ? -3.586  13.187  -3.351  1.000 11.945  0  15  ILE A CA    1 ? 
ATOM   128  C C     . ILE A 1 15  ? -2.278  12.782  -2.668  1.000 12.464  0  15  ILE A C     1 ? 
ATOM   129  O O     . ILE A 1 15  ? -2.343  12.003  -1.722  1.000 14.204  0  15  ILE A O     1 ? 
ATOM   130  C CB    . ILE A 1 15  ? -4.144  12.057  -4.223  1.000 11.527  0  15  ILE A CB    1 ? 
ATOM   131  C CG1   . ILE A 1 15  ? -3.130  11.607  -5.257  1.000 10.502  0  15  ILE A CG1   1 ? 
ATOM   132  C CG2   . ILE A 1 15  ? -5.477  12.443  -4.837  1.000 12.784  0  15  ILE A CG2   1 ? 
ATOM   133  C CD1   . ILE A 1 15  ? -3.586  10.450  -6.146  1.000 11.324  0  15  ILE A CD1   1 ? 
ATOM   134  N N     . LYS A 1 16  ? -1.138  13.268  -3.131  1.000 13.021  0  16  LYS A N     1 ? 
ATOM   135  C CA    . LYS A 1 16  ? 0.179   12.858  -2.606  1.000 14.379  0  16  LYS A CA    1 ? 
ATOM   136  C C     . LYS A 1 16  ? 0.310   13.263  -1.130  1.000 15.587  0  16  LYS A C     1 ? 
ATOM   137  O O     . LYS A 1 16  ? -0.080  14.378  -0.765  1.000 15.287  0  16  LYS A O     1 ? 
ATOM   138  C CB    . LYS A 1 16  ? 1.297   13.445  -3.459  1.000 16.123  0  16  LYS A CB    1 ? 
ATOM   139  C CG    . LYS A 1 16  ? 2.676   13.087  -2.967  1.000 17.746  0  16  LYS A CG    1 ? 
ATOM   140  C CD    . LYS A 1 16  ? 3.813   13.675  -3.740  1.000 20.145  0  16  LYS A CD    1 ? 
ATOM   141  C CE    . LYS A 1 16  ? 5.143   13.471  -3.029  1.000 21.984  0  16  LYS A CE    1 ? 
ATOM   142  N NZ    . LYS A 1 16  ? 6.272   13.585  -3.975  1.000 24.457  0  16  LYS A NZ    1 ? 
ATOM   143  N N     . LEU A 1 17  ? 0.811   12.365  -0.304  1.000 15.601  0  17  LEU A N     1 ? 
ATOM   144  C CA    . LEU A 1 17  ? 1.296   12.718  1.062   1.000 18.708  0  17  LEU A CA    1 ? 
ATOM   145  C C     . LEU A 1 17  ? 2.788   12.433  1.118   1.000 18.014  0  17  LEU A C     1 ? 
ATOM   146  O O     . LEU A 1 17  ? 3.136   11.297  0.833   1.000 15.817  0  17  LEU A O     1 ? 
ATOM   147  C CB    . LEU A 1 17  ? 0.522   11.885  2.082   1.000 20.567  0  17  LEU A CB    1 ? 
ATOM   148  C CG    . LEU A 1 17  ? 0.760   12.230  3.557   1.000 23.321  0  17  LEU A CG    1 ? 
ATOM   149  C CD1   . LEU A 1 17  ? 0.755   13.727  3.810   1.000 24.173  0  17  LEU A CD1   1 ? 
ATOM   150  C CD2   . LEU A 1 17  ? -0.288  11.558  4.419   1.000 22.987  0  17  LEU A CD2   1 ? 
ATOM   151  N N     . ALA A 1 18  ? 3.616   13.441  1.460   1.000 16.305  0  18  ALA A N     1 ? 
ATOM   152  C CA    . ALA A 1 18  ? 5.099   13.392  1.436   1.000 17.037  0  18  ALA A CA    1 ? 
ATOM   153  C C     . ALA A 1 18  ? 5.641   12.244  2.309   1.000 16.668  0  18  ALA A C     1 ? 
ATOM   154  O O     . ALA A 1 18  ? 5.054   11.931  3.364   1.000 17.493  0  18  ALA A O     1 ? 
ATOM   155  C CB    . ALA A 1 18  ? 5.668   14.726  1.878   1.000 19.378  0  18  ALA A CB    1 ? 
ATOM   156  N N     . GLN A 1 19  ? 6.677   11.578  1.814   1.000 17.632  0  19  GLN A N     1 ? 
ATOM   157  C CA    . GLN A 1 19  ? 7.299   10.397  2.458   1.000 19.446  0  19  GLN A CA    1 ? 
ATOM   158  C C     . GLN A 1 19  ? 7.955   10.827  3.776   1.000 21.937  0  19  GLN A C     1 ? 
ATOM   159  O O     . GLN A 1 19  ? 8.154   12.085  4.000   1.000 21.117  0  19  GLN A O     1 ? 
ATOM   160  C CB    . GLN A 1 19  ? 8.315   9.771   1.517   1.000 19.647  0  19  GLN A CB    1 ? 
ATOM   161  C CG    . GLN A 1 19  ? 9.524   10.636  1.275   1.000 20.723  0  19  GLN A CG    1 ? 
ATOM   162  C CD    . GLN A 1 19  ? 10.507  9.992   0.355   1.000 21.135  0  19  GLN A CD    1 ? 
ATOM   163  O OE1   . GLN A 1 19  ? 10.926  8.860   0.564   1.000 24.547  0  19  GLN A OE1   1 ? 
ATOM   164  N NE2   . GLN A 1 19  ? 10.870  10.717  -0.683  1.000 23.282  0  19  GLN A NE2   1 ? 
ATOM   165  N N     . TYR A 1 20  ? 8.352   9.865   4.605   1.000 19.921  0  20  TYR A N     1 ? 
ATOM   166  C CA    . TYR A 1 20  ? 8.992   10.164  5.920   1.000 21.429  0  20  TYR A CA    1 ? 
ATOM   167  C C     . TYR A 1 20  ? 10.058  11.241  5.736   1.000 21.408  0  20  TYR A C     1 ? 
ATOM   168  O O     . TYR A 1 20  ? 9.999   12.269  6.467   1.000 22.735  0  20  TYR A O     1 ? 
ATOM   169  C CB    . TYR A 1 20  ? 9.602   8.904   6.543   1.000 19.412  0  20  TYR A CB    1 ? 
ATOM   170  C CG    . TYR A 1 20  ? 8.604   8.003   7.214   1.000 19.472  0  20  TYR A CG    1 ? 
ATOM   171  C CD1   . TYR A 1 20  ? 7.732   8.480   8.181   1.000 20.091  0  20  TYR A CD1   1 ? 
ATOM   172  C CD2   . TYR A 1 20  ? 8.524   6.661   6.881   1.000 18.847  0  20  TYR A CD2   1 ? 
ATOM   173  C CE1   . TYR A 1 20  ? 6.835   7.654   8.818   1.000 20.795  0  20  TYR A CE1   1 ? 
ATOM   174  C CE2   . TYR A 1 20  ? 7.618   5.823   7.500   1.000 18.487  0  20  TYR A CE2   1 ? 
ATOM   175  C CZ    . TYR A 1 20  ? 6.800   6.305   8.502   1.000 20.671  0  20  TYR A CZ    1 ? 
ATOM   176  O OH    . TYR A 1 20  ? 5.904   5.480   9.128   1.000 22.182  0  20  TYR A OH    1 ? 
ATOM   177  N N     . ASP A 1 21  ? 10.977  11.034  4.785   1.000 25.143  0  21  ASP A N     1 ? 
ATOM   178  C CA    . ASP A 1 21  ? 12.224  11.835  4.613   1.000 29.647  0  21  ASP A CA    1 ? 
ATOM   179  C C     . ASP A 1 21  ? 11.861  13.268  4.217   1.000 31.742  0  21  ASP A C     1 ? 
ATOM   180  O O     . ASP A 1 21  ? 12.727  14.147  4.365   1.000 32.221  0  21  ASP A O     1 ? 
ATOM   181  C CB    . ASP A 1 21  ? 13.181  11.218  3.583   1.000 32.803  0  21  ASP A CB    1 ? 
ATOM   182  C CG    . ASP A 1 21  ? 13.825  9.900   4.020   1.000 34.323  0  21  ASP A CG    1 ? 
ATOM   183  O OD1   . ASP A 1 21  ? 14.454  9.234   3.158   1.000 39.261  0  21  ASP A OD1   1 ? 
ATOM   184  O OD2   . ASP A 1 21  ? 13.663  9.525   5.199   1.000 35.089  0  21  ASP A OD2   1 ? 
ATOM   185  N N     . GLU A 1 22  ? 10.621  13.505  3.777   1.000 26.943  0  22  GLU A N     1 ? 
ATOM   186  C CA    . GLU A 1 22  ? 10.167  14.852  3.351   1.000 30.345  0  22  GLU A CA    1 ? 
ATOM   187  C C     . GLU A 1 22  ? 9.039   15.344  4.259   1.000 28.858  0  22  GLU A C     1 ? 
ATOM   188  O O     . GLU A 1 22  ? 8.433   16.336  3.898   1.000 31.593  0  22  GLU A O     1 ? 
ATOM   189  C CB    . GLU A 1 22  ? 9.723   14.806  1.886   1.000 28.590  0  22  GLU A CB    1 ? 
ATOM   190  C CG    . GLU A 1 22  ? 10.853  14.502  0.939   1.000 29.517  0  22  GLU A CG    1 ? 
ATOM   191  C CD    . GLU A 1 22  ? 10.442  14.431  -0.523  1.000 34.202  0  22  GLU A CD    1 ? 
ATOM   192  O OE1   . GLU A 1 22  ? 10.619  15.439  -1.234  1.000 38.205  0  22  GLU A OE1   1 ? 
ATOM   193  O OE2   . GLU A 1 22  ? 9.953   13.370  -0.951  1.000 36.629  0  22  GLU A OE2   1 ? 
ATOM   194  N N     . ASN A 1 23  ? 8.731   14.669  5.372   1.000 27.827  0  23  ASN A N     1 ? 
ATOM   195  C CA    . ASN A 1 23  ? 7.473   14.935  6.119   1.000 26.880  0  23  ASN A CA    1 ? 
ATOM   196  C C     . ASN A 1 23  ? 7.707   14.959  7.648   1.000 29.907  0  23  ASN A C     1 ? 
ATOM   197  O O     . ASN A 1 23  ? 7.453   13.940  8.317   1.000 27.548  0  23  ASN A O     1 ? 
ATOM   198  C CB    . ASN A 1 23  ? 6.395   13.950  5.715   1.000 25.826  0  23  ASN A CB    1 ? 
ATOM   199  C CG    . ASN A 1 23  ? 5.010   14.420  6.093   1.000 26.425  0  23  ASN A CG    1 ? 
ATOM   200  O OD1   . ASN A 1 23  ? 4.825   15.113  7.100   1.000 31.131  0  23  ASN A OD1   1 ? 
ATOM   201  N ND2   . ASN A 1 23  ? 4.026   14.015  5.310   1.000 23.284  0  23  ASN A ND2   1 ? 
ATOM   202  N N     . GLN A 1 24  ? 8.009   16.146  8.199   1.000 33.815  0  24  GLN A N     1 ? 
ATOM   203  C CA    . GLN A 1 24  ? 8.269   16.368  9.654   1.000 33.480  0  24  GLN A CA    1 ? 
ATOM   204  C C     . GLN A 1 24  ? 7.135   15.817  10.513  1.000 35.041  0  24  GLN A C     1 ? 
ATOM   205  O O     . GLN A 1 24  ? 7.434   15.113  11.495  1.000 39.113  0  24  GLN A O     1 ? 
ATOM   206  C CB    . GLN A 1 24  ? 8.442   17.856  9.934   1.000 41.991  0  24  GLN A CB    1 ? 
ATOM   207  C CG    . GLN A 1 24  ? 9.840   18.358  9.616   1.000 45.303  0  24  GLN A CG    1 ? 
ATOM   208  C CD    . GLN A 1 24  ? 10.717  18.367  10.844  1.000 54.464  0  24  GLN A CD    1 ? 
ATOM   209  O OE1   . GLN A 1 24  ? 11.075  17.318  11.390  1.000 54.492  0  24  GLN A OE1   1 ? 
ATOM   210  N NE2   . GLN A 1 24  ? 11.056  19.563  11.302  1.000 58.918  0  24  GLN A NE2   1 ? 
ATOM   211  N N     . THR A 1 25  ? 5.882   16.138  10.185  1.000 33.971  0  25  THR A N     1 ? 
ATOM   212  C CA    . THR A 1 25  ? 4.679   15.716  10.956  1.000 35.584  0  25  THR A CA    1 ? 
ATOM   213  C C     . THR A 1 25  ? 4.678   14.181  11.120  1.000 34.440  0  25  THR A C     1 ? 
ATOM   214  O O     . THR A 1 25  ? 4.407   13.697  12.235  1.000 28.122  0  25  THR A O     1 ? 
ATOM   215  C CB    . THR A 1 25  ? 3.393   16.222  10.289  1.000 37.948  0  25  THR A CB    1 ? 
ATOM   216  O OG1   . THR A 1 25  ? 3.445   17.644  10.239  1.000 42.328  0  25  THR A OG1   1 ? 
ATOM   217  C CG2   . THR A 1 25  ? 2.137   15.809  11.017  1.000 40.122  0  25  THR A CG2   1 ? 
ATOM   218  N N     . LEU A 1 26  ? 4.929   13.424  10.043  1.000 31.892  0  26  LEU A N     1 ? 
ATOM   219  C CA    . LEU A 1 26  ? 4.875   11.941  10.114  1.000 28.180  0  26  LEU A CA    1 ? 
ATOM   220  C C     . LEU A 1 26  ? 6.046   11.449  10.972  1.000 25.360  0  26  LEU A C     1 ? 
ATOM   221  O O     . LEU A 1 26  ? 5.802   10.526  11.819  1.000 26.550  0  26  LEU A O     1 ? 
ATOM   222  C CB    . LEU A 1 26  ? 4.899   11.324  8.711   1.000 26.918  0  26  LEU A CB    1 ? 
ATOM   223  C CG    . LEU A 1 26  ? 3.650   11.542  7.863   1.000 28.140  0  26  LEU A CG    1 ? 
ATOM   224  C CD1   . LEU A 1 26  ? 3.744   10.751  6.566   1.000 31.125  0  26  LEU A CD1   1 ? 
ATOM   225  C CD2   . LEU A 1 26  ? 2.398   11.156  8.615   1.000 28.423  0  26  LEU A CD2   1 ? 
ATOM   226  N N     . ARG A 1 27  ? 7.240   12.020  10.786  1.000 26.313  0  27  ARG A N     1 ? 
ATOM   227  C CA    . ARG A 1 27  ? 8.457   11.645  11.573  1.000 29.614  0  27  ARG A CA    1 ? 
ATOM   228  C C     . ARG A 1 27  ? 8.194   11.859  13.073  1.000 29.245  0  27  ARG A C     1 ? 
ATOM   229  O O     . ARG A 1 27  ? 8.603   11.013  13.845  1.000 28.411  0  27  ARG A O     1 ? 
ATOM   230  C CB    . ARG A 1 27  ? 9.699   12.416  11.130  1.000 28.737  0  27  ARG A CB    1 ? 
ATOM   231  C CG    . ARG A 1 27  ? 10.216  12.013  9.761   1.000 30.984  0  27  ARG A CG    1 ? 
ATOM   232  C CD    . ARG A 1 27  ? 11.630  12.439  9.495   1.000 31.851  0  27  ARG A CD    1 ? 
ATOM   233  N NE    . ARG A 1 27  ? 11.829  13.853  9.741   1.000 35.933  0  27  ARG A NE    1 ? 
ATOM   234  C CZ    . ARG A 1 27  ? 11.669  14.818  8.836   1.000 39.512  0  27  ARG A CZ    1 ? 
ATOM   235  N NH1   . ARG A 1 27  ? 11.264  14.535  7.604   1.000 35.395  0  27  ARG A NH1   1 ? 
ATOM   236  N NH2   . ARG A 1 27  ? 11.902  16.075  9.174   1.000 35.721  0  27  ARG A NH2   1 ? 
ATOM   237  N N     . ASP A 1 28  ? 7.483   12.925  13.451  1.000 31.140  0  28  ASP A N     1 ? 
ATOM   238  C CA    . ASP A 1 28  ? 7.162   13.256  14.866  1.000 30.853  0  28  ASP A CA    1 ? 
ATOM   239  C C     . ASP A 1 28  ? 6.128   12.271  15.398  1.000 32.024  0  28  ASP A C     1 ? 
ATOM   240  O O     . ASP A 1 28  ? 6.327   11.749  16.481  1.000 33.098  0  28  ASP A O     1 ? 
ATOM   241  C CB    . ASP A 1 28  ? 6.612   14.679  15.000  1.000 35.630  0  28  ASP A CB    1 ? 
ATOM   242  C CG    . ASP A 1 28  ? 7.616   15.768  14.693  1.000 35.189  0  28  ASP A CG    1 ? 
ATOM   243  O OD1   . ASP A 1 28  ? 8.807   15.442  14.526  1.000 38.334  0  28  ASP A OD1   1 ? 
ATOM   244  O OD2   . ASP A 1 28  ? 7.199   16.949  14.647  1.000 44.633  0  28  ASP A OD2   1 ? 
ATOM   245  N N     . GLU A 1 29  ? 5.059   12.006  14.655  1.000 29.715  0  29  GLU A N     1 ? 
ATOM   246  C CA    . GLU A 1 29  ? 4.015   11.051  15.106  1.000 33.075  0  29  GLU A CA    1 ? 
ATOM   247  C C     . GLU A 1 29  ? 4.645   9.655   15.267  1.000 32.804  0  29  GLU A C     1 ? 
ATOM   248  O O     . GLU A 1 29  ? 4.280   8.956   16.204  1.000 33.439  0  29  GLU A O     1 ? 
ATOM   249  C CB    . GLU A 1 29  ? 2.837   11.076  14.133  1.000 34.618  0  29  GLU A CB    1 ? 
ATOM   250  C CG    . GLU A 1 29  ? 2.122   12.417  14.141  1.000 37.594  0  29  GLU A CG    1 ? 
ATOM   251  C CD    . GLU A 1 29  ? 1.339   12.765  12.891  1.000 41.567  0  29  GLU A CD    1 ? 
ATOM   252  O OE1   . GLU A 1 29  ? 0.739   13.857  12.871  1.000 45.985  0  29  GLU A OE1   1 ? 
ATOM   253  O OE2   . GLU A 1 29  ? 1.310   11.945  11.957  1.000 44.594  0  29  GLU A OE2   1 ? 
ATOM   254  N N     . ARG A 1 30  ? 5.522   9.259   14.345  1.000 32.454  0  30  ARG A N     1 ? 
ATOM   255  C CA    . ARG A 1 30  ? 6.258   7.969   14.390  1.000 30.374  0  30  ARG A CA    1 ? 
ATOM   256  C C     . ARG A 1 30  ? 7.099   7.910   15.680  1.000 33.518  0  30  ARG A C     1 ? 
ATOM   257  O O     . ARG A 1 30  ? 6.907   6.947   16.487  1.000 32.264  0  30  ARG A O     1 ? 
ATOM   258  C CB    . ARG A 1 30  ? 7.179   7.866   13.176  1.000 28.718  0  30  ARG A CB    1 ? 
ATOM   259  C CG    . ARG A 1 30  ? 8.088   6.643   13.174  1.000 27.432  0  30  ARG A CG    1 ? 
ATOM   260  C CD    . ARG A 1 30  ? 9.163   6.767   12.127  1.000 28.161  0  30  ARG A CD    1 ? 
ATOM   261  N NE    . ARG A 1 30  ? 10.044  7.884   12.432  1.000 27.821  0  30  ARG A NE    1 ? 
ATOM   262  C CZ    . ARG A 1 30  ? 10.878  8.423   11.578  1.000 27.712  0  30  ARG A CZ    1 ? 
ATOM   263  N NH1   . ARG A 1 30  ? 10.943  7.978   10.334  1.000 30.981  0  30  ARG A NH1   1 ? 
ATOM   264  N NH2   . ARG A 1 30  ? 11.616  9.442   11.946  1.000 30.116  0  30  ARG A NH2   1 ? 
ATOM   265  N N     . ASP A 1 31  ? 8.002   8.889   15.834  1.000 32.885  0  31  ASP A N     1 ? 
ATOM   266  C CA    . ASP A 1 31  ? 8.998   8.997   16.935  1.000 39.408  0  31  ASP A CA    1 ? 
ATOM   267  C C     . ASP A 1 31  ? 8.286   9.050   18.300  1.000 39.336  0  31  ASP A C     1 ? 
ATOM   268  O O     . ASP A 1 31  ? 8.793   8.424   19.257  1.000 42.617  0  31  ASP A O     1 ? 
ATOM   269  C CB    . ASP A 1 31  ? 9.942   10.178  16.675  1.000 39.704  0  31  ASP A CB    1 ? 
ATOM   270  C CG    . ASP A 1 31  ? 10.916  9.894   15.541  1.000 42.357  0  31  ASP A CG    1 ? 
ATOM   271  O OD1   . ASP A 1 31  ? 10.862  8.763   14.996  1.000 47.406  0  31  ASP A OD1   1 ? 
ATOM   272  O OD2   . ASP A 1 31  ? 11.725  10.777  15.212  1.000 41.045  0  31  ASP A OD2   1 ? 
ATOM   273  N N     . ALA A 1 32  ? 7.144   9.729   18.402  1.000 40.382  0  32  ALA A N     1 ? 
ATOM   274  C CA    . ALA A 1 32  ? 6.337   9.774   19.646  1.000 42.718  0  32  ALA A CA    1 ? 
ATOM   275  C C     . ALA A 1 32  ? 5.876   8.351   20.009  1.000 44.438  0  32  ALA A C     1 ? 
ATOM   276  O O     . ALA A 1 32  ? 5.831   8.028   21.220  1.000 40.947  0  32  ALA A O     1 ? 
ATOM   277  C CB    . ALA A 1 32  ? 5.160   10.712  19.504  1.000 41.823  0  32  ALA A CB    1 ? 
ATOM   278  N N     . VAL A 1 33  ? 5.509   7.529   19.021  1.000 35.086  0  33  VAL A N     1 ? 
ATOM   279  C CA    . VAL A 1 33  ? 4.999   6.155   19.305  1.000 36.632  0  33  VAL A CA    1 ? 
ATOM   280  C C     . VAL A 1 33  ? 6.203   5.279   19.658  1.000 35.198  0  33  VAL A C     1 ? 
ATOM   281  O O     . VAL A 1 33  ? 6.059   4.427   20.553  1.000 36.261  0  33  VAL A O     1 ? 
ATOM   282  C CB    . VAL A 1 33  ? 4.138   5.580   18.162  1.000 36.555  0  33  VAL A CB    1 ? 
ATOM   283  C CG1   . VAL A 1 33  ? 4.028   4.060   18.245  1.000 39.508  0  33  VAL A CG1   1 ? 
ATOM   284  C CG2   . VAL A 1 33  ? 2.749   6.203   18.156  1.000 35.034  0  33  VAL A CG2   1 ? 
ATOM   285  N N     . LEU A 1 34  ? 7.376   5.584   19.096  1.000 38.203  0  34  LEU A N     1 ? 
ATOM   286  C CA    . LEU A 1 34  ? 8.635   4.838   19.376  1.000 39.468  0  34  LEU A CA    1 ? 
ATOM   287  C C     . LEU A 1 34  ? 9.045   5.104   20.833  1.000 41.672  0  34  LEU A C     1 ? 
ATOM   288  O O     . LEU A 1 34  ? 9.222   4.118   21.595  1.000 41.109  0  34  LEU A O     1 ? 
ATOM   289  C CB    . LEU A 1 34  ? 9.715   5.245   18.364  1.000 36.417  0  34  LEU A CB    1 ? 
ATOM   290  C CG    . LEU A 1 34  ? 9.455   4.769   16.921  1.000 34.031  0  34  LEU A CG    1 ? 
ATOM   291  C CD1   . LEU A 1 34  ? 10.630  5.085   16.002  1.000 33.572  0  34  LEU A CD1   1 ? 
ATOM   292  C CD2   . LEU A 1 34  ? 9.139   3.278   16.872  1.000 33.721  0  34  LEU A CD2   1 ? 
ATOM   293  N N     . THR A 1 35  ? 9.090   6.374   21.231  1.000 43.685  0  35  THR A N     1 ? 
ATOM   294  C CA    . THR A 1 35  ? 9.356   6.797   22.635  1.000 44.273  0  35  THR A CA    1 ? 
ATOM   295  C C     . THR A 1 35  ? 8.373   6.048   23.550  1.000 41.499  0  35  THR A C     1 ? 
ATOM   296  O O     . THR A 1 35  ? 8.832   5.299   24.437  1.000 39.592  0  35  THR A O     1 ? 
ATOM   297  C CB    . THR A 1 35  ? 9.318   8.328   22.740  1.000 45.471  0  35  THR A CB    1 ? 
ATOM   298  O OG1   . THR A 1 35  ? 10.300  8.828   21.823  1.000 38.430  0  35  THR A OG1   1 ? 
ATOM   299  C CG2   . THR A 1 35  ? 9.605   8.846   24.136  1.000 46.325  0  35  THR A CG2   1 ? 
ATOM   300  N N     . ALA A 1 36  ? 7.076   6.156   23.270  1.000 42.974  0  36  ALA A N     1 ? 
ATOM   301  C CA    . ALA A 1 36  ? 5.986   5.517   24.048  1.000 42.876  0  36  ALA A CA    1 ? 
ATOM   302  C C     . ALA A 1 36  ? 6.244   4.009   24.233  1.000 44.758  0  36  ALA A C     1 ? 
ATOM   303  O O     . ALA A 1 36  ? 5.858   3.479   25.305  1.000 44.708  0  36  ALA A O     1 ? 
ATOM   304  C CB    . ALA A 1 36  ? 4.656   5.786   23.392  1.000 45.921  0  36  ALA A CB    1 ? 
ATOM   305  N N     . VAL A 1 37  ? 6.870   3.335   23.259  1.000 41.928  0  37  VAL A N     1 ? 
ATOM   306  C CA    . VAL A 1 37  ? 7.177   1.873   23.337  1.000 42.940  0  37  VAL A CA    1 ? 
ATOM   307  C C     . VAL A 1 37  ? 8.371   1.657   24.278  1.000 41.567  0  37  VAL A C     1 ? 
ATOM   308  O O     . VAL A 1 37  ? 8.296   0.728   25.106  1.000 36.393  0  37  VAL A O     1 ? 
ATOM   309  C CB    . VAL A 1 37  ? 7.431   1.251   21.947  1.000 46.288  0  37  VAL A CB    1 ? 
ATOM   310  C CG1   . VAL A 1 37  ? 8.081   -0.127  22.053  1.000 47.099  0  37  VAL A CG1   1 ? 
ATOM   311  C CG2   . VAL A 1 37  ? 6.148   1.169   21.136  1.000 42.188  0  37  VAL A CG2   1 ? 
ATOM   312  N N     . ARG A 1 38  ? 9.431   2.458   24.146  1.000 41.080  0  38  ARG A N     1 ? 
ATOM   313  C CA    . ARG A 1 38  ? 10.639  2.370   25.011  1.000 44.177  0  38  ARG A CA    1 ? 
ATOM   314  C C     . ARG A 1 38  ? 10.203  2.506   26.481  1.000 45.568  0  38  ARG A C     1 ? 
ATOM   315  O O     . ARG A 1 38  ? 10.370  1.525   27.267  1.000 39.265  0  38  ARG A O     1 ? 
ATOM   316  C CB    . ARG A 1 38  ? 11.657  3.442   24.601  1.000 47.170  0  38  ARG A CB    1 ? 
ATOM   317  C CG    . ARG A 1 38  ? 12.268  3.216   23.225  1.000 52.449  0  38  ARG A CG    1 ? 
ATOM   318  C CD    . ARG A 1 38  ? 13.569  3.962   22.996  1.000 53.710  0  38  ARG A CD    1 ? 
ATOM   319  N NE    . ARG A 1 38  ? 14.146  3.753   21.664  1.000 61.913  0  38  ARG A NE    1 ? 
ATOM   320  C CZ    . ARG A 1 38  ? 14.738  2.625   21.238  1.000 68.211  0  38  ARG A CZ    1 ? 
ATOM   321  N NH1   . ARG A 1 38  ? 15.245  2.561   20.015  1.000 58.814  0  38  ARG A NH1   1 ? 
ATOM   322  N NH2   . ARG A 1 38  ? 14.812  1.560   22.026  1.000 76.335  0  38  ARG A NH2   1 ? 
ATOM   323  N N     . GLU A 1 39  ? 9.577   3.632   26.825  1.000 45.336  0  39  GLU A N     1 ? 
ATOM   324  C CA    . GLU A 1 39  ? 9.076   3.904   28.204  1.000 49.146  0  39  GLU A CA    1 ? 
ATOM   325  C C     . GLU A 1 39  ? 8.132   2.767   28.626  1.000 54.817  0  39  GLU A C     1 ? 
ATOM   326  O O     . GLU A 1 39  ? 8.383   2.158   29.690  1.000 60.271  0  39  GLU A O     1 ? 
ATOM   327  C CB    . GLU A 1 39  ? 8.378   5.263   28.287  1.000 49.866  0  39  GLU A CB    1 ? 
ATOM   328  C CG    . GLU A 1 39  ? 9.111   6.376   27.558  1.000 54.340  0  39  GLU A CG    1 ? 
ATOM   329  C CD    . GLU A 1 39  ? 10.627  6.356   27.659  1.000 57.615  0  39  GLU A CD    1 ? 
ATOM   330  O OE1   . GLU A 1 39  ? 11.280  5.760   26.770  1.000 60.096  0  39  GLU A OE1   1 ? 
ATOM   331  O OE2   . GLU A 1 39  ? 11.153  6.956   28.608  1.000 68.873  0  39  GLU A OE2   1 ? 
ATOM   332  N N     . GLY A 1 40  ? 7.117   2.474   27.803  1.000 52.686  0  40  GLY A N     1 ? 
ATOM   333  C CA    . GLY A 1 40  ? 6.123   1.400   28.015  1.000 53.015  0  40  GLY A CA    1 ? 
ATOM   334  C C     . GLY A 1 40  ? 6.767   0.059   28.336  1.000 52.856  0  40  GLY A C     1 ? 
ATOM   335  O O     . GLY A 1 40  ? 6.215   -0.662  29.185  1.000 56.477  0  40  GLY A O     1 ? 
ATOM   336  N N     . LEU A 1 41  ? 7.903   -0.259  27.706  1.000 51.878  0  41  LEU A N     1 ? 
ATOM   337  C CA    . LEU A 1 41  ? 8.605   -1.569  27.853  1.000 49.786  0  41  LEU A CA    1 ? 
ATOM   338  C C     . LEU A 1 41  ? 9.257   -1.679  29.243  1.000 49.739  0  41  LEU A C     1 ? 
ATOM   339  O O     . LEU A 1 41  ? 9.295   -2.811  29.780  1.000 49.502  0  41  LEU A O     1 ? 
ATOM   340  C CB    . LEU A 1 41  ? 9.661   -1.734  26.751  1.000 50.440  0  41  LEU A CB    1 ? 
ATOM   341  C CG    . LEU A 1 41  ? 9.173   -2.322  25.426  1.000 48.090  0  41  LEU A CG    1 ? 
ATOM   342  C CD1   . LEU A 1 41  ? 10.330  -2.431  24.440  1.000 46.839  0  41  LEU A CD1   1 ? 
ATOM   343  C CD2   . LEU A 1 41  ? 8.496   -3.677  25.623  1.000 49.745  0  41  LEU A CD2   1 ? 
ATOM   344  N N     . LYS A 1 42  ? 9.783   -0.576  29.788  1.000 48.963  0  42  LYS A N     1 ? 
ATOM   345  C CA    . LYS A 1 42  ? 10.349  -0.543  31.166  1.000 50.901  0  42  LYS A CA    1 ? 
ATOM   346  C C     . LYS A 1 42  ? 9.298   -1.133  32.109  1.000 47.036  0  42  LYS A C     1 ? 
ATOM   347  O O     . LYS A 1 42  ? 9.607   -2.116  32.784  1.000 53.381  0  42  LYS A O     1 ? 
ATOM   348  C CB    . LYS A 1 42  ? 10.743  0.882   31.581  1.000 50.731  0  42  LYS A CB    1 ? 
ATOM   349  C CG    . LYS A 1 42  ? 11.729  1.570   30.646  1.000 53.021  0  42  LYS A CG    1 ? 
ATOM   350  C CD    . LYS A 1 42  ? 12.980  2.086   31.319  1.000 54.308  0  42  LYS A CD    1 ? 
ATOM   351  C CE    . LYS A 1 42  ? 14.001  2.602   30.321  1.000 56.635  0  42  LYS A CE    1 ? 
ATOM   352  N NZ    . LYS A 1 42  ? 15.391  2.479   30.831  1.000 58.965  0  42  LYS A NZ    1 ? 
ATOM   353  N N     . LYS A 1 43  ? 8.084   -0.586  32.056  1.000 48.646  0  43  LYS A N     1 ? 
ATOM   354  C CA    . LYS A 1 43  ? 6.912   -0.963  32.892  1.000 52.170  0  43  LYS A CA    1 ? 
ATOM   355  C C     . LYS A 1 43  ? 6.702   -2.476  32.818  1.000 54.696  0  43  LYS A C     1 ? 
ATOM   356  O O     . LYS A 1 43  ? 6.590   -3.120  33.893  1.000 54.641  0  43  LYS A O     1 ? 
ATOM   357  C CB    . LYS A 1 43  ? 5.662   -0.226  32.400  1.000 54.486  0  43  LYS A CB    1 ? 
ATOM   358  C CG    . LYS A 1 43  ? 4.343   -0.628  33.058  1.000 61.583  0  43  LYS A CG    1 ? 
ATOM   359  C CD    . LYS A 1 43  ? 3.248   -1.058  32.072  1.000 64.586  0  43  LYS A CD    1 ? 
ATOM   360  C CE    . LYS A 1 43  ? 2.842   0.021   31.086  1.000 67.504  0  43  LYS A CE    1 ? 
ATOM   361  N NZ    . LYS A 1 43  ? 2.259   1.200   31.774  1.000 65.847  0  43  LYS A NZ    1 ? 
ATOM   362  N N     . VAL A 1 44  ? 6.643   -3.025  31.602  1.000 45.176  0  44  VAL A N     1 ? 
ATOM   363  C CA    . VAL A 1 44  ? 6.233   -4.439  31.381  1.000 47.228  0  44  VAL A CA    1 ? 
ATOM   364  C C     . VAL A 1 44  ? 7.315   -5.338  31.999  1.000 49.115  0  44  VAL A C     1 ? 
ATOM   365  O O     . VAL A 1 44  ? 6.938   -6.370  32.612  1.000 44.158  0  44  VAL A O     1 ? 
ATOM   366  C CB    . VAL A 1 44  ? 5.981   -4.749  29.890  1.000 48.884  0  44  VAL A CB    1 ? 
ATOM   367  C CG1   . VAL A 1 44  ? 5.573   -6.203  29.675  1.000 48.773  0  44  VAL A CG1   1 ? 
ATOM   368  C CG2   . VAL A 1 44  ? 4.932   -3.813  29.282  1.000 48.335  0  44  VAL A CG2   1 ? 
ATOM   369  N N     . PHE A 1 45  ? 8.592   -4.925  31.910  1.000 45.144  0  45  PHE A N     1 ? 
ATOM   370  C CA    . PHE A 1 45  ? 9.774   -5.771  32.239  1.000 44.422  0  45  PHE A CA    1 ? 
ATOM   371  C C     . PHE A 1 45  ? 10.143  -5.646  33.727  1.000 44.932  0  45  PHE A C     1 ? 
ATOM   372  O O     . PHE A 1 45  ? 10.865  -6.538  34.228  1.000 46.367  0  45  PHE A O     1 ? 
ATOM   373  C CB    . PHE A 1 45  ? 10.922  -5.505  31.257  1.000 40.205  0  45  PHE A CB    1 ? 
ATOM   374  C CG    . PHE A 1 45  ? 10.803  -6.379  30.033  1.000 44.647  0  45  PHE A CG    1 ? 
ATOM   375  C CD1   . PHE A 1 45  ? 9.913   -6.051  29.014  1.000 43.044  0  45  PHE A CD1   1 ? 
ATOM   376  C CD2   . PHE A 1 45  ? 11.438  -7.610  29.976  1.000 41.540  0  45  PHE A CD2   1 ? 
ATOM   377  C CE1   . PHE A 1 45  ? 9.737   -6.889  27.926  1.000 42.607  0  45  PHE A CE1   1 ? 
ATOM   378  C CE2   . PHE A 1 45  ? 11.251  -8.454  28.888  1.000 47.032  0  45  PHE A CE2   1 ? 
ATOM   379  C CZ    . PHE A 1 45  ? 10.406  -8.089  27.860  1.000 46.578  0  45  PHE A CZ    1 ? 
ATOM   380  N N     . ALA A 1 46  ? 9.587   -4.657  34.430  1.000 49.493  0  46  ALA A N     1 ? 
ATOM   381  C CA    . ALA A 1 46  ? 9.806   -4.421  35.880  1.000 52.671  0  46  ALA A CA    1 ? 
ATOM   382  C C     . ALA A 1 46  ? 9.191   -5.572  36.691  1.000 55.851  0  46  ALA A C     1 ? 
ATOM   383  O O     . ALA A 1 46  ? 9.600   -5.748  37.850  1.000 48.982  0  46  ALA A O     1 ? 
ATOM   384  C CB    . ALA A 1 46  ? 9.229   -3.088  36.286  1.000 50.972  0  46  ALA A CB    1 ? 
ATOM   385  N N     . ASP A 1 47  ? 8.248   -6.311  36.083  1.000 55.265  0  47  ASP A N     1 ? 
ATOM   386  C CA    . ASP A 1 47  ? 7.531   -7.486  36.660  1.000 56.484  0  47  ASP A CA    1 ? 
ATOM   387  C C     . ASP A 1 47  ? 8.305   -8.790  36.405  1.000 53.070  0  47  ASP A C     1 ? 
ATOM   388  O O     . ASP A 1 47  ? 7.853   -9.853  36.881  1.000 45.479  0  47  ASP A O     1 ? 
ATOM   389  C CB    . ASP A 1 47  ? 6.140   -7.620  36.033  1.000 59.768  0  47  ASP A CB    1 ? 
ATOM   390  C CG    . ASP A 1 47  ? 5.106   -6.723  36.675  1.000 62.177  0  47  ASP A CG    1 ? 
ATOM   391  O OD1   . ASP A 1 47  ? 4.972   -6.792  37.909  1.000 60.455  0  47  ASP A OD1   1 ? 
ATOM   392  O OD2   . ASP A 1 47  ? 4.462   -5.951  35.938  1.000 66.533  0  47  ASP A OD2   1 ? 
ATOM   393  N N     . ARG A 1 48  ? 9.390   -8.730  35.633  1.000 50.053  0  48  ARG A N     1 ? 
ATOM   394  C CA    . ARG A 1 48  ? 10.162  -9.927  35.207  1.000 51.108  0  48  ARG A CA    1 ? 
ATOM   395  C C     . ARG A 1 48  ? 11.598  -9.823  35.720  1.000 42.732  0  48  ARG A C     1 ? 
ATOM   396  O O     . ARG A 1 48  ? 12.283  -10.844 35.655  1.000 42.402  0  48  ARG A O     1 ? 
ATOM   397  C CB    . ARG A 1 48  ? 10.110  -10.072 33.683  1.000 58.917  0  48  ARG A CB    1 ? 
ATOM   398  C CG    . ARG A 1 48  ? 8.695   -10.069 33.116  1.000 65.222  0  48  ARG A CG    1 ? 
ATOM   399  C CD    . ARG A 1 48  ? 8.660   -9.862  31.607  1.000 67.911  0  48  ARG A CD    1 ? 
ATOM   400  N NE    . ARG A 1 48  ? 9.369   -10.919 30.894  1.000 68.278  0  48  ARG A NE    1 ? 
ATOM   401  C CZ    . ARG A 1 48  ? 8.824   -11.764 30.015  1.000 68.383  0  48  ARG A CZ    1 ? 
ATOM   402  N NH1   . ARG A 1 48  ? 9.588   -12.680 29.440  1.000 69.050  0  48  ARG A NH1   1 ? 
ATOM   403  N NH2   . ARG A 1 48  ? 7.538   -11.693 29.703  1.000 63.402  0  48  ARG A NH2   1 ? 
ATOM   404  N N     . GLY A 1 49  ? 12.038  -8.617  36.122  1.000 41.615  0  49  GLY A N     1 ? 
ATOM   405  C CA    . GLY A 1 49  ? 13.189  -8.382  37.020  1.000 45.211  0  49  GLY A CA    1 ? 
ATOM   406  C C     . GLY A 1 49  ? 14.488  -8.139  36.268  1.000 48.895  0  49  GLY A C     1 ? 
ATOM   407  O O     . GLY A 1 49  ? 15.548  -8.563  36.757  1.000 43.762  0  49  GLY A O     1 ? 
ATOM   408  N N     . GLU A 1 50  ? 14.414  -7.473  35.115  1.000 48.786  0  50  GLU A N     1 ? 
ATOM   409  C CA    . GLU A 1 50  ? 15.566  -7.245  34.215  1.000 44.663  0  50  GLU A CA    1 ? 
ATOM   410  C C     . GLU A 1 50  ? 15.225  -6.094  33.272  1.000 44.823  0  50  GLU A C     1 ? 
ATOM   411  O O     . GLU A 1 50  ? 14.024  -5.738  33.171  1.000 44.687  0  50  GLU A O     1 ? 
ATOM   412  C CB    . GLU A 1 50  ? 15.858  -8.522  33.435  1.000 44.304  0  50  GLU A CB    1 ? 
ATOM   413  C CG    . GLU A 1 50  ? 14.593  -9.189  32.939  1.000 44.370  0  50  GLU A CG    1 ? 
ATOM   414  C CD    . GLU A 1 50  ? 14.748  -10.177 31.794  1.000 46.207  0  50  GLU A CD    1 ? 
ATOM   415  O OE1   . GLU A 1 50  ? 15.906  -10.430 31.357  1.000 44.651  0  50  GLU A OE1   1 ? 
ATOM   416  O OE2   . GLU A 1 50  ? 13.702  -10.698 31.339  1.000 41.132  0  50  GLU A OE2   1 ? 
ATOM   417  N N     . ALA A 1 51  ? 16.246  -5.529  32.632  1.000 44.446  0  51  ALA A N     1 ? 
ATOM   418  C CA    . ALA A 1 51  ? 16.120  -4.531  31.546  1.000 46.050  0  51  ALA A CA    1 ? 
ATOM   419  C C     . ALA A 1 51  ? 15.198  -5.086  30.450  1.000 45.013  0  51  ALA A C     1 ? 
ATOM   420  O O     . ALA A 1 51  ? 15.396  -6.240  30.045  1.000 36.840  0  51  ALA A O     1 ? 
ATOM   421  C CB    . ALA A 1 51  ? 17.490  -4.203  30.994  1.000 45.849  0  51  ALA A CB    1 ? 
ATOM   422  N N     . ALA A 1 52  ? 14.230  -4.284  29.993  1.000 47.474  0  52  ALA A N     1 ? 
ATOM   423  C CA    . ALA A 1 52  ? 13.474  -4.511  28.737  1.000 44.303  0  52  ALA A CA    1 ? 
ATOM   424  C C     . ALA A 1 52  ? 14.462  -4.659  27.580  1.000 39.471  0  52  ALA A C     1 ? 
ATOM   425  O O     . ALA A 1 52  ? 15.544  -4.083  27.590  1.000 34.058  0  52  ALA A O     1 ? 
ATOM   426  C CB    . ALA A 1 52  ? 12.507  -3.381  28.504  1.000 44.125  0  52  ALA A CB    1 ? 
ATOM   427  N N     . PRO A 1 53  ? 14.160  -5.489  26.564  1.000 40.538  0  53  PRO A N     1 ? 
ATOM   428  C CA    . PRO A 1 53  ? 15.036  -5.591  25.405  1.000 40.282  0  53  PRO A CA    1 ? 
ATOM   429  C C     . PRO A 1 53  ? 15.016  -4.273  24.625  1.000 37.039  0  53  PRO A C     1 ? 
ATOM   430  O O     . PRO A 1 53  ? 14.004  -3.582  24.652  1.000 38.996  0  53  PRO A O     1 ? 
ATOM   431  C CB    . PRO A 1 53  ? 14.444  -6.761  24.606  1.000 41.942  0  53  PRO A CB    1 ? 
ATOM   432  C CG    . PRO A 1 53  ? 12.983  -6.773  25.003  1.000 42.633  0  53  PRO A CG    1 ? 
ATOM   433  C CD    . PRO A 1 53  ? 12.966  -6.339  26.454  1.000 40.885  0  53  PRO A CD    1 ? 
ATOM   434  N N     . THR A 1 54  ? 16.151  -3.914  24.038  1.000 36.213  0  54  THR A N     1 ? 
ATOM   435  C CA    . THR A 1 54  ? 16.282  -2.777  23.091  1.000 35.956  0  54  THR A CA    1 ? 
ATOM   436  C C     . THR A 1 54  ? 15.729  -3.201  21.713  1.000 33.491  0  54  THR A C     1 ? 
ATOM   437  O O     . THR A 1 54  ? 15.599  -4.431  21.438  1.000 28.966  0  54  THR A O     1 ? 
ATOM   438  C CB    . THR A 1 54  ? 17.735  -2.294  23.046  1.000 35.069  0  54  THR A CB    1 ? 
ATOM   439  O OG1   . THR A 1 54  ? 18.514  -3.347  22.489  1.000 31.847  0  54  THR A OG1   1 ? 
ATOM   440  C CG2   . THR A 1 54  ? 18.278  -1.926  24.411  1.000 39.119  0  54  THR A CG2   1 ? 
ATOM   441  N N     . PHE A 1 55  ? 15.390  -2.235  20.869  1.000 36.024  0  55  PHE A N     1 ? 
ATOM   442  C CA    . PHE A 1 55  ? 14.892  -2.505  19.493  1.000 33.305  0  55  PHE A CA    1 ? 
ATOM   443  C C     . PHE A 1 55  ? 15.527  -1.502  18.534  1.000 33.075  0  55  PHE A C     1 ? 
ATOM   444  O O     . PHE A 1 55  ? 15.932  -0.394  18.976  1.000 31.449  0  55  PHE A O     1 ? 
ATOM   445  C CB    . PHE A 1 55  ? 13.363  -2.498  19.464  1.000 32.263  0  55  PHE A CB    1 ? 
ATOM   446  C CG    . PHE A 1 55  ? 12.751  -1.148  19.730  1.000 35.450  0  55  PHE A CG    1 ? 
ATOM   447  C CD1   . PHE A 1 55  ? 12.651  -0.201  18.720  1.000 31.531  0  55  PHE A CD1   1 ? 
ATOM   448  C CD2   . PHE A 1 55  ? 12.327  -0.806  21.006  1.000 37.109  0  55  PHE A CD2   1 ? 
ATOM   449  C CE1   . PHE A 1 55  ? 12.140  1.060   18.985  1.000 35.004  0  55  PHE A CE1   1 ? 
ATOM   450  C CE2   . PHE A 1 55  ? 11.785  0.445   21.259  1.000 37.106  0  55  PHE A CE2   1 ? 
ATOM   451  C CZ    . PHE A 1 55  ? 11.705  1.378   20.251  1.000 38.312  0  55  PHE A CZ    1 ? 
ATOM   452  N N     . THR A 1 56  ? 15.691  -1.916  17.277  1.000 29.567  0  56  THR A N     1 ? 
ATOM   453  C CA    . THR A 1 56  ? 16.095  -1.046  16.148  1.000 28.440  0  56  THR A CA    1 ? 
ATOM   454  C C     . THR A 1 56  ? 14.867  -0.779  15.287  1.000 26.974  0  56  THR A C     1 ? 
ATOM   455  O O     . THR A 1 56  ? 14.246  -1.726  14.793  1.000 21.822  0  56  THR A O     1 ? 
ATOM   456  C CB    . THR A 1 56  ? 17.212  -1.699  15.348  1.000 30.601  0  56  THR A CB    1 ? 
ATOM   457  O OG1   . THR A 1 56  ? 18.200  -2.055  16.307  1.000 34.832  0  56  THR A OG1   1 ? 
ATOM   458  C CG2   . THR A 1 56  ? 17.808  -0.796  14.292  1.000 29.043  0  56  THR A CG2   1 ? 
ATOM   459  N N     . PRO A 1 57  ? 14.436  0.499   15.149  1.000 26.222  0  57  PRO A N     1 ? 
ATOM   460  C CA    . PRO A 1 57  ? 13.258  0.820   14.354  1.000 23.859  0  57  PRO A CA    1 ? 
ATOM   461  C C     . PRO A 1 57  ? 13.677  1.023   12.896  1.000 22.666  0  57  PRO A C     1 ? 
ATOM   462  O O     . PRO A 1 57  ? 14.806  1.266   12.666  1.000 21.447  0  57  PRO A O     1 ? 
ATOM   463  C CB    . PRO A 1 57  ? 12.747  2.114   15.016  1.000 26.286  0  57  PRO A CB    1 ? 
ATOM   464  C CG    . PRO A 1 57  ? 14.038  2.814   15.460  1.000 25.109  0  57  PRO A CG    1 ? 
ATOM   465  C CD    . PRO A 1 57  ? 15.006  1.691   15.806  1.000 25.663  0  57  PRO A CD    1 ? 
ATOM   466  N N     . PHE A 1 58  ? 12.775  0.784   11.940  1.000 21.139  0  58  PHE A N     1 ? 
ATOM   467  C CA    . PHE A 1 58  ? 13.005  1.158   10.531  1.000 19.268  0  58  PHE A CA    1 ? 
ATOM   468  C C     . PHE A 1 58  ? 11.669  1.502   9.883   1.000 17.654  0  58  PHE A C     1 ? 
ATOM   469  O O     . PHE A 1 58  ? 10.612  0.998   10.300  1.000 18.835  0  58  PHE A O     1 ? 
ATOM   470  C CB    . PHE A 1 58  ? 13.764  0.073   9.775   1.000 18.722  0  58  PHE A CB    1 ? 
ATOM   471  C CG    . PHE A 1 58  ? 13.020  -1.222  9.643   1.000 18.744  0  58  PHE A CG    1 ? 
ATOM   472  C CD1   . PHE A 1 58  ? 13.005  -2.134  10.686  1.000 18.408  0  58  PHE A CD1   1 ? 
ATOM   473  C CD2   . PHE A 1 58  ? 12.330  -1.532  8.488   1.000 16.657  0  58  PHE A CD2   1 ? 
ATOM   474  C CE1   . PHE A 1 58  ? 12.321  -3.330  10.568  1.000 17.880  0  58  PHE A CE1   1 ? 
ATOM   475  C CE2   . PHE A 1 58  ? 11.630  -2.727  8.379   1.000 18.049  0  58  PHE A CE2   1 ? 
ATOM   476  C CZ    . PHE A 1 58  ? 11.628  -3.624  9.419   1.000 19.086  0  58  PHE A CZ    1 ? 
ATOM   477  N N     . ASN A 1 59  ? 11.708  2.405   8.916   1.000 19.020  0  59  ASN A N     1 ? 
ATOM   478  C CA    . ASN A 1 59  ? 10.490  2.860   8.203   1.000 18.099  0  59  ASN A CA    1 ? 
ATOM   479  C C     . ASN A 1 59  ? 9.903   1.701   7.397   1.000 17.883  0  59  ASN A C     1 ? 
ATOM   480  O O     . ASN A 1 59  ? 10.688  0.968   6.779   1.000 17.228  0  59  ASN A O     1 ? 
ATOM   481  C CB    . ASN A 1 59  ? 10.817  4.037   7.291   1.000 19.856  0  59  ASN A CB    1 ? 
ATOM   482  C CG    . ASN A 1 59  ? 11.198  5.277   8.062   1.000 21.412  0  59  ASN A CG    1 ? 
ATOM   483  O OD1   . ASN A 1 59  ? 10.812  5.453   9.233   1.000 21.468  0  59  ASN A OD1   1 ? 
ATOM   484  N ND2   . ASN A 1 59  ? 12.000  6.103   7.435   1.000 20.564  0  59  ASN A ND2   1 ? 
ATOM   485  N N     . GLN A 1 60  ? 8.583   1.570   7.357   1.000 17.601  0  60  GLN A N     1 ? 
ATOM   486  C CA    . GLN A 1 60  ? 7.920   0.590   6.447   1.000 19.896  0  60  GLN A CA    1 ? 
ATOM   487  C C     . GLN A 1 60  ? 6.800   1.272   5.692   1.000 17.128  0  60  GLN A C     1 ? 
ATOM   488  O O     . GLN A 1 60  ? 6.396   2.383   6.113   1.000 16.923  0  60  GLN A O     1 ? 
ATOM   489  C CB    . GLN A 1 60  ? 7.285   -0.565  7.226   1.000 21.742  0  60  GLN A CB    1 ? 
ATOM   490  C CG    . GLN A 1 60  ? 8.292   -1.467  7.875   1.000 23.890  0  60  GLN A CG    1 ? 
ATOM   491  C CD    . GLN A 1 60  ? 7.686   -2.801  8.213   1.000 23.941  0  60  GLN A CD    1 ? 
ATOM   492  O OE1   . GLN A 1 60  ? 6.735   -3.274  7.596   1.000 31.774  0  60  GLN A OE1   1 ? 
ATOM   493  N NE2   . GLN A 1 60  ? 8.267   -3.435  9.177   1.000 23.375  0  60  GLN A NE2   1 ? 
ATOM   494  N N     . GLY A 1 61  ? 6.228   0.557   4.724   1.000 15.145  0  61  GLY A N     1 ? 
ATOM   495  C CA    . GLY A 1 61  ? 4.961   0.926   4.071   1.000 14.952  0  61  GLY A CA    1 ? 
ATOM   496  C C     . GLY A 1 61  ? 5.071   2.158   3.201   1.000 14.073  0  61  GLY A C     1 ? 
ATOM   497  O O     . GLY A 1 61  ? 6.196   2.524   2.771   1.000 13.275  0  61  GLY A O     1 ? 
ATOM   498  N N     . SER A 1 62  ? 3.931   2.777   2.925   1.000 13.933  0  62  SER A N     1 ? 
ATOM   499  C CA    . SER A 1 62  ? 3.791   3.789   1.856   1.000 16.446  0  62  SER A CA    1 ? 
ATOM   500  C C     . SER A 1 62  ? 4.686   5.003   2.139   1.000 16.093  0  62  SER A C     1 ? 
ATOM   501  O O     . SER A 1 62  ? 5.250   5.523   1.191   1.000 13.661  0  62  SER A O     1 ? 
ATOM   502  C CB    . SER A 1 62  ? 2.333   4.148   1.631   1.000 17.758  0  62  SER A CB    1 ? 
ATOM   503  O OG    . SER A 1 62  ? 1.774   4.825   2.740   1.000 22.793  0  62  SER A OG    1 ? 
ATOM   504  N N     . TYR A 1 63  ? 4.897   5.387   3.405   1.000 16.442  0  63  TYR A N     1 ? 
ATOM   505  C CA    . TYR A 1 63  ? 5.684   6.610   3.722   1.000 17.570  0  63  TYR A CA    1 ? 
ATOM   506  C C     . TYR A 1 63  ? 7.180   6.327   3.659   1.000 17.575  0  63  TYR A C     1 ? 
ATOM   507  O O     . TYR A 1 63  ? 7.943   7.326   3.618   1.000 18.928  0  63  TYR A O     1 ? 
ATOM   508  C CB    . TYR A 1 63  ? 5.147   7.246   5.013   1.000 18.293  0  63  TYR A CB    1 ? 
ATOM   509  C CG    . TYR A 1 63  ? 3.703   7.581   4.787   1.000 20.475  0  63  TYR A CG    1 ? 
ATOM   510  C CD1   . TYR A 1 63  ? 3.337   8.467   3.776   1.000 22.340  0  63  TYR A CD1   1 ? 
ATOM   511  C CD2   . TYR A 1 63  ? 2.704   6.877   5.413   1.000 22.825  0  63  TYR A CD2   1 ? 
ATOM   512  C CE1   . TYR A 1 63  ? 2.006   8.705   3.479   1.000 22.860  0  63  TYR A CE1   1 ? 
ATOM   513  C CE2   . TYR A 1 63  ? 1.367   7.090   5.107   1.000 23.648  0  63  TYR A CE2   1 ? 
ATOM   514  C CZ    . TYR A 1 63  ? 1.019   8.001   4.141   1.000 21.681  0  63  TYR A CZ    1 ? 
ATOM   515  O OH    . TYR A 1 63  ? -0.299  8.215   3.876   1.000 25.200  0  63  TYR A OH    1 ? 
ATOM   516  N N     . ALA A 1 64  ? 7.586   5.049   3.631   1.000 15.084  0  64  ALA A N     1 ? 
ATOM   517  C CA    . ALA A 1 64  ? 8.975   4.608   3.357   1.000 14.942  0  64  ALA A CA    1 ? 
ATOM   518  C C     . ALA A 1 64  ? 9.235   4.499   1.845   1.000 15.571  0  64  ALA A C     1 ? 
ATOM   519  O O     . ALA A 1 64  ? 10.321  4.791   1.409   1.000 16.389  0  64  ALA A O     1 ? 
ATOM   520  C CB    . ALA A 1 64  ? 9.224   3.272   4.028   1.000 15.303  0  64  ALA A CB    1 ? 
ATOM   521  N N     . MET A 1 65  ? 8.253   4.031   1.089   1.000 15.765  0  65  MET A N     1 ? 
ATOM   522  C CA    . MET A 1 65  ? 8.372   3.755   -0.367  1.000 14.635  0  65  MET A CA    1 ? 
ATOM   523  C C     . MET A 1 65  ? 8.008   4.974   -1.222  1.000 13.467  0  65  MET A C     1 ? 
ATOM   524  O O     . MET A 1 65  ? 8.119   4.869   -2.468  1.000 14.119  0  65  MET A O     1 ? 
ATOM   525  C CB    . MET A 1 65  ? 7.460   2.589   -0.711  1.000 14.569  0  65  MET A CB    1 ? 
ATOM   526  C CG    . MET A 1 65  ? 7.973   1.342   -0.124  1.000 16.360  0  65  MET A CG    1 ? 
ATOM   527  S SD    . MET A 1 65  ? 7.156   -0.134  -0.646  1.000 17.302  0  65  MET A SD    1 ? 
ATOM   528  C CE    . MET A 1 65  ? 5.704   -0.085  0.393   1.000 21.548  0  65  MET A CE    1 ? 
ATOM   529  N N     . ASN A 1 66  ? 7.517   6.053   -0.607  1.000 13.314  0  66  ASN A N     1 ? 
ATOM   530  C CA    . ASN A 1 66  ? 7.117   7.310   -1.281  1.000 12.998  0  66  ASN A CA    1 ? 
ATOM   531  C C     . ASN A 1 66  ? 5.967   7.015   -2.251  1.000 11.650  0  66  ASN A C     1 ? 
ATOM   532  O O     . ASN A 1 66  ? 5.976   7.521   -3.370  1.000 10.153  0  66  ASN A O     1 ? 
ATOM   533  C CB    . ASN A 1 66  ? 8.294   7.975   -1.970  1.000 13.975  0  66  ASN A CB    1 ? 
ATOM   534  C CG    . ASN A 1 66  ? 8.015   9.383   -2.428  1.000 15.024  0  66  ASN A CG    1 ? 
ATOM   535  O OD1   . ASN A 1 66  ? 7.095   10.042  -1.934  1.000 14.945  0  66  ASN A OD1   1 ? 
ATOM   536  N ND2   . ASN A 1 66  ? 8.855   9.875   -3.334  1.000 14.274  0  66  ASN A ND2   1 ? 
ATOM   537  N N     . THR A 1 67  ? 5.008   6.262   -1.776  1.000 12.769  0  67  THR A N     1 ? 
ATOM   538  C CA    . THR A 1 67  ? 3.745   5.902   -2.478  1.000 13.327  0  67  THR A CA    1 ? 
ATOM   539  C C     . THR A 1 67  ? 2.552   6.332   -1.624  1.000 12.961  0  67  THR A C     1 ? 
ATOM   540  O O     . THR A 1 67  ? 1.460   5.793   -1.830  1.000 13.665  0  67  THR A O     1 ? 
ATOM   541  C CB    . THR A 1 67  ? 3.681   4.402   -2.784  1.000 13.813  0  67  THR A CB    1 ? 
ATOM   542  O OG1   . THR A 1 67  ? 3.780   3.684   -1.546  1.000 15.645  0  67  THR A OG1   1 ? 
ATOM   543  C CG2   . THR A 1 67  ? 4.782   3.981   -3.732  1.000 15.957  0  67  THR A CG2   1 ? 
ATOM   544  N N     . GLY A 1 68  ? 2.723   7.306   -0.733  1.000 12.261  0  68  GLY A N     1 ? 
ATOM   545  C CA    . GLY A 1 68  ? 1.673   7.655   0.238   1.000 13.091  0  68  GLY A CA    1 ? 
ATOM   546  C C     . GLY A 1 68  ? 0.620   8.574   -0.343  1.000 13.039  0  68  GLY A C     1 ? 
ATOM   547  O O     . GLY A 1 68  ? 0.986   9.476   -1.125  1.000 13.178  0  68  GLY A O     1 ? 
ATOM   548  N N     . VAL A 1 69  ? -0.625  8.407   0.105   1.000 13.129  0  69  VAL A N     1 ? 
ATOM   549  C CA    . VAL A 1 69  ? -1.768  9.258   -0.297  1.000 13.587  0  69  VAL A CA    1 ? 
ATOM   550  C C     . VAL A 1 69  ? -2.445  9.809   0.955   1.000 14.867  0  69  VAL A C     1 ? 
ATOM   551  O O     . VAL A 1 69  ? -2.380  9.177   2.027   1.000 14.508  0  69  VAL A O     1 ? 
ATOM   552  C CB    . VAL A 1 69  ? -2.786  8.534   -1.203  1.000 13.074  0  69  VAL A CB    1 ? 
ATOM   553  C CG1   . VAL A 1 69  ? -2.168  8.157   -2.540  1.000 13.459  0  69  VAL A CG1   1 ? 
ATOM   554  C CG2   . VAL A 1 69  ? -3.387  7.326   -0.526  1.000 13.833  0  69  VAL A CG2   1 ? 
ATOM   555  N N     . LYS A 1 70  ? -3.051  10.981  0.816   1.000 15.597  0  70  LYS A N     1 ? 
ATOM   556  C CA    . LYS A 1 70  ? -3.891  11.556  1.878   1.000 15.434  0  70  LYS A CA    1 ? 
ATOM   557  C C     . LYS A 1 70  ? -5.138  10.705  1.931   1.000 15.693  0  70  LYS A C     1 ? 
ATOM   558  O O     . LYS A 1 70  ? -5.635  10.269  0.889   1.000 15.546  0  70  LYS A O     1 ? 
ATOM   559  C CB    . LYS A 1 70  ? -4.180  13.021  1.551   1.000 16.544  0  70  LYS A CB    1 ? 
ATOM   560  C CG    . LYS A 1 70  ? -2.947  13.899  1.523   1.000 18.131  0  70  LYS A CG    1 ? 
ATOM   561  C CD    . LYS A 1 70  ? -3.285  15.343  1.357   1.000 19.530  0  70  LYS A CD    1 ? 
ATOM   562  C CE    . LYS A 1 70  ? -2.069  16.202  1.491   1.000 22.848  0  70  LYS A CE    1 ? 
ATOM   563  N NZ    . LYS A 1 70  ? -2.315  17.533  0.912   1.000 24.046  0  70  LYS A NZ    1 ? 
ATOM   564  N N     . PRO A 1 71  ? -5.702  10.450  3.127   1.000 17.050  0  71  PRO A N     1 ? 
ATOM   565  C CA    . PRO A 1 71  ? -7.000  9.795   3.214   1.000 18.363  0  71  PRO A CA    1 ? 
ATOM   566  C C     . PRO A 1 71  ? -8.107  10.688  2.643   1.000 20.385  0  71  PRO A C     1 ? 
ATOM   567  O O     . PRO A 1 71  ? -7.898  11.878  2.515   1.000 19.955  0  71  PRO A O     1 ? 
ATOM   568  C CB    . PRO A 1 71  ? -7.214  9.574   4.712   1.000 19.085  0  71  PRO A CB    1 ? 
ATOM   569  C CG    . PRO A 1 71  ? -6.324  10.583  5.399   1.000 18.226  0  71  PRO A CG    1 ? 
ATOM   570  C CD    . PRO A 1 71  ? -5.203  10.909  4.435   1.000 18.282  0  71  PRO A CD    1 ? 
ATOM   571  N N     . LEU A 1 72  ? -9.261  10.112  2.342   1.000 21.160  0  72  LEU A N     1 ? 
ATOM   572  C CA    . LEU A 1 72  ? -10.474 10.907  2.084   1.000 23.491  0  72  LEU A CA    1 ? 
ATOM   573  C C     . LEU A 1 72  ? -10.813 11.715  3.337   1.000 26.536  0  72  LEU A C     1 ? 
ATOM   574  O O     . LEU A 1 72  ? -10.393 11.333  4.429   1.000 22.873  0  72  LEU A O     1 ? 
ATOM   575  C CB    . LEU A 1 72  ? -11.613 9.972   1.707   1.000 23.518  0  72  LEU A CB    1 ? 
ATOM   576  C CG    . LEU A 1 72  ? -11.370 9.180   0.436   1.000 25.281  0  72  LEU A CG    1 ? 
ATOM   577  C CD1   . LEU A 1 72  ? -12.576 8.310   0.106   1.000 26.929  0  72  LEU A CD1   1 ? 
ATOM   578  C CD2   . LEU A 1 72  ? -10.995 10.118  -0.696  1.000 24.890  0  72  LEU A CD2   1 ? 
ATOM   579  N N     . GLU A 1 73  ? -11.575 12.787  3.172   1.000 31.241  0  73  GLU A N     1 ? 
ATOM   580  C CA    . GLU A 1 73  ? -11.978 13.683  4.291   1.000 38.803  0  73  GLU A CA    1 ? 
ATOM   581  C C     . GLU A 1 73  ? -12.540 12.806  5.418   1.000 36.287  0  73  GLU A C     1 ? 
ATOM   582  O O     . GLU A 1 73  ? -13.390 11.924  5.132   1.000 31.018  0  73  GLU A O     1 ? 
ATOM   583  C CB    . GLU A 1 73  ? -12.948 14.749  3.767   1.000 43.020  0  73  GLU A CB    1 ? 
ATOM   584  C CG    . GLU A 1 73  ? -13.235 15.866  4.751   1.000 48.144  0  73  GLU A CG    1 ? 
ATOM   585  C CD    . GLU A 1 73  ? -14.695 16.280  4.721   1.000 54.875  0  73  GLU A CD    1 ? 
ATOM   586  O OE1   . GLU A 1 73  ? -15.192 16.599  3.607   1.000 54.247  0  73  GLU A OE1   1 ? 
ATOM   587  O OE2   . GLU A 1 73  ? -15.351 16.212  5.792   1.000 61.287  0  73  GLU A OE2   1 ? 
ATOM   588  N N     . GLY A 1 74  ? -11.966 12.934  6.620   1.000 42.320  0  74  GLY A N     1 ? 
ATOM   589  C CA    . GLY A 1 74  ? -12.393 12.214  7.838   1.000 45.932  0  74  GLY A CA    1 ? 
ATOM   590  C C     . GLY A 1 74  ? -11.989 10.743  7.842   1.000 50.180  0  74  GLY A C     1 ? 
ATOM   591  O O     . GLY A 1 74  ? -12.442 10.017  8.745   1.000 48.549  0  74  GLY A O     1 ? 
ATOM   592  N N     . GLY A 1 75  ? -11.169 10.303  6.879   1.000 44.013  0  75  GLY A N     1 ? 
ATOM   593  C CA    . GLY A 1 75  ? -10.447 9.019   6.958   1.000 39.360  0  75  GLY A CA    1 ? 
ATOM   594  C C     . GLY A 1 75  ? -9.187  9.160   7.793   1.000 33.130  0  75  GLY A C     1 ? 
ATOM   595  O O     . GLY A 1 75  ? -8.886  10.281  8.234   1.000 31.424  0  75  GLY A O     1 ? 
ATOM   596  N N     . GLU A 1 76  ? -8.463  8.063   8.004   1.000 35.845  0  76  GLU A N     1 ? 
ATOM   597  C CA    . GLU A 1 76  ? -7.189  8.041   8.767   1.000 36.793  0  76  GLU A CA    1 ? 
ATOM   598  C C     . GLU A 1 76  ? -6.080  7.563   7.838   1.000 33.590  0  76  GLU A C     1 ? 
ATOM   599  O O     . GLU A 1 76  ? -6.358  6.716   6.994   1.000 34.792  0  76  GLU A O     1 ? 
ATOM   600  C CB    . GLU A 1 76  ? -7.285  7.114   9.986   1.000 43.553  0  76  GLU A CB    1 ? 
ATOM   601  C CG    . GLU A 1 76  ? -8.277  7.583   11.052  1.000 49.523  0  76  GLU A CG    1 ? 
ATOM   602  C CD    . GLU A 1 76  ? -8.266  6.800   12.366  1.000 56.024  0  76  GLU A CD    1 ? 
ATOM   603  O OE1   . GLU A 1 76  ? -9.066  7.157   13.273  1.000 53.285  0  76  GLU A OE1   1 ? 
ATOM   604  O OE2   . GLU A 1 76  ? -7.451  5.837   12.492  1.000 56.327  0  76  GLU A OE2   1 ? 
ATOM   605  N N     . TYR A 1 77  ? -4.862  8.053   8.026   1.000 29.258  0  77  TYR A N     1 ? 
ATOM   606  C CA    . TYR A 1 77  ? -3.665  7.471   7.379   1.000 34.927  0  77  TYR A CA    1 ? 
ATOM   607  C C     . TYR A 1 77  ? -2.978  6.534   8.384   1.000 34.953  0  77  TYR A C     1 ? 
ATOM   608  O O     . TYR A 1 77  ? -3.313  6.554   9.603   1.000 33.711  0  77  TYR A O     1 ? 
ATOM   609  C CB    . TYR A 1 77  ? -2.776  8.571   6.801   1.000 34.503  0  77  TYR A CB    1 ? 
ATOM   610  C CG    . TYR A 1 77  ? -2.240  9.574   7.787   1.000 37.489  0  77  TYR A CG    1 ? 
ATOM   611  C CD1   . TYR A 1 77  ? -1.125  9.286   8.553   1.000 37.159  0  77  TYR A CD1   1 ? 
ATOM   612  C CD2   . TYR A 1 77  ? -2.784  10.850  7.879   1.000 39.275  0  77  TYR A CD2   1 ? 
ATOM   613  C CE1   . TYR A 1 77  ? -0.571  10.229  9.402   1.000 41.472  0  77  TYR A CE1   1 ? 
ATOM   614  C CE2   . TYR A 1 77  ? -2.253  11.800  8.739   1.000 41.462  0  77  TYR A CE2   1 ? 
ATOM   615  C CZ    . TYR A 1 77  ? -1.140  11.487  9.502   1.000 41.147  0  77  TYR A CZ    1 ? 
ATOM   616  O OH    . TYR A 1 77  ? -0.604  12.394  10.371  1.000 44.682  0  77  TYR A OH    1 ? 
ATOM   617  N N     . ASP A 1 78  ? -2.153  5.629   7.876   1.000 35.328  0  78  ASP A N     1 ? 
ATOM   618  C CA    . ASP A 1 78  ? -1.408  4.669   8.724   1.000 31.065  0  78  ASP A CA    1 ? 
ATOM   619  C C     . ASP A 1 78  ? 0.081   4.944   8.558   1.000 30.207  0  78  ASP A C     1 ? 
ATOM   620  O O     . ASP A 1 78  ? 0.577   4.958   7.401   1.000 27.784  0  78  ASP A O     1 ? 
ATOM   621  C CB    . ASP A 1 78  ? -1.800  3.223   8.441   1.000 40.007  0  78  ASP A CB    1 ? 
ATOM   622  C CG    . ASP A 1 78  ? -1.439  2.744   7.057   1.000 44.230  0  78  ASP A CG    1 ? 
ATOM   623  O OD1   . ASP A 1 78  ? -0.387  2.109   6.912   1.000 43.155  0  78  ASP A OD1   1 ? 
ATOM   624  O OD2   . ASP A 1 78  ? -2.232  2.998   6.149   1.000 57.267  0  78  ASP A OD2   1 ? 
ATOM   625  N N     . ILE A 1 79  ? 0.737   5.224   9.678   1.000 24.969  0  79  ILE A N     1 ? 
ATOM   626  C CA    . ILE A 1 79  ? 2.202   5.320   9.817   1.000 28.133  0  79  ILE A CA    1 ? 
ATOM   627  C C     . ILE A 1 79  ? 2.681   3.887   10.066  1.000 28.945  0  79  ILE A C     1 ? 
ATOM   628  O O     . ILE A 1 79  ? 2.185   3.263   11.028  1.000 24.809  0  79  ILE A O     1 ? 
ATOM   629  C CB    . ILE A 1 79  ? 2.582   6.239   10.993  1.000 33.413  0  79  ILE A CB    1 ? 
ATOM   630  C CG1   . ILE A 1 79  ? 1.974   7.634   10.865  1.000 39.686  0  79  ILE A CG1   1 ? 
ATOM   631  C CG2   . ILE A 1 79  ? 4.087   6.310   11.156  1.000 32.731  0  79  ILE A CG2   1 ? 
ATOM   632  C CD1   . ILE A 1 79  ? 2.328   8.555   12.027  1.000 41.326  0  79  ILE A CD1   1 ? 
ATOM   633  N N     . ASP A 1 80  ? 3.578   3.374   9.227   1.000 24.628  0  80  ASP A N     1 ? 
ATOM   634  C CA    . ASP A 1 80  ? 4.056   1.976   9.356   1.000 23.815  0  80  ASP A CA    1 ? 
ATOM   635  C C     . ASP A 1 80  ? 5.504   2.020   9.800   1.000 20.751  0  80  ASP A C     1 ? 
ATOM   636  O O     . ASP A 1 80  ? 6.281   2.791   9.223   1.000 20.729  0  80  ASP A O     1 ? 
ATOM   637  C CB    . ASP A 1 80  ? 3.830   1.190   8.072   1.000 24.451  0  80  ASP A CB    1 ? 
ATOM   638  C CG    . ASP A 1 80  ? 2.378   1.059   7.650   1.000 27.289  0  80  ASP A CG    1 ? 
ATOM   639  O OD1   . ASP A 1 80  ? 2.149   1.033   6.427   1.000 31.942  0  80  ASP A OD1   1 ? 
ATOM   640  O OD2   . ASP A 1 80  ? 1.480   0.957   8.530   1.000 29.955  0  80  ASP A OD2   1 ? 
ATOM   641  N N     . VAL A 1 81  ? 5.856   1.188   10.778  1.000 20.517  0  81  VAL A N     1 ? 
ATOM   642  C CA    . VAL A 1 81  ? 7.222   1.153   11.376  1.000 22.976  0  81  VAL A CA    1 ? 
ATOM   643  C C     . VAL A 1 81  ? 7.514   -0.295  11.758  1.000 20.316  0  81  VAL A C     1 ? 
ATOM   644  O O     . VAL A 1 81  ? 6.580   -1.018  12.104  1.000 21.625  0  81  VAL A O     1 ? 
ATOM   645  C CB    . VAL A 1 81  ? 7.381   2.107   12.576  1.000 25.725  0  81  VAL A CB    1 ? 
ATOM   646  C CG1   . VAL A 1 81  ? 8.841   2.277   12.954  1.000 29.943  0  81  VAL A CG1   1 ? 
ATOM   647  C CG2   . VAL A 1 81  ? 6.784   3.467   12.304  1.000 30.436  0  81  VAL A CG2   1 ? 
ATOM   648  N N     . GLY A 1 82  ? 8.746   -0.718  11.530  1.000 21.117  0  82  GLY A N     1 ? 
ATOM   649  C CA    . GLY A 1 82  ? 9.265   -2.001  12.018  1.000 19.530  0  82  GLY A CA    1 ? 
ATOM   650  C C     . GLY A 1 82  ? 10.103  -1.762  13.245  1.000 19.519  0  82  GLY A C     1 ? 
ATOM   651  O O     . GLY A 1 82  ? 10.864  -0.772  13.246  1.000 19.338  0  82  GLY A O     1 ? 
ATOM   652  N N     . ILE A 1 83  ? 10.007  -2.651  14.233  1.000 22.555  0  83  ILE A N     1 ? 
ATOM   653  C CA    . ILE A 1 83  ? 10.968  -2.675  15.380  1.000 23.516  0  83  ILE A CA    1 ? 
ATOM   654  C C     . ILE A 1 83  ? 11.556  -4.073  15.497  1.000 19.103  0  83  ILE A C     1 ? 
ATOM   655  O O     . ILE A 1 83  ? 10.796  -5.050  15.547  1.000 21.686  0  83  ILE A O     1 ? 
ATOM   656  C CB    . ILE A 1 83  ? 10.308  -2.212  16.687  1.000 27.317  0  83  ILE A CB    1 ? 
ATOM   657  C CG1   . ILE A 1 83  ? 9.115   -3.094  17.055  1.000 29.169  0  83  ILE A CG1   1 ? 
ATOM   658  C CG2   . ILE A 1 83  ? 9.924   -0.743  16.575  1.000 28.290  0  83  ILE A CG2   1 ? 
ATOM   659  C CD1   . ILE A 1 83  ? 8.392   -2.643  18.315  1.000 31.617  0  83  ILE A CD1   1 ? 
ATOM   660  N N     . ILE A 1 84  ? 12.859  -4.170  15.416  1.000 18.970  0  84  ILE A N     1 ? 
ATOM   661  C CA    . ILE A 1 84  ? 13.575  -5.468  15.557  1.000 21.335  0  84  ILE A CA    1 ? 
ATOM   662  C C     . ILE A 1 84  ? 14.058  -5.563  17.004  1.000 23.310  0  84  ILE A C     1 ? 
ATOM   663  O O     . ILE A 1 84  ? 15.003  -4.844  17.347  1.000 25.680  0  84  ILE A O     1 ? 
ATOM   664  C CB    . ILE A 1 84  ? 14.749  -5.566  14.591  1.000 20.178  0  84  ILE A CB    1 ? 
ATOM   665  C CG1   . ILE A 1 84  ? 14.324  -5.187  13.168  1.000 19.621  0  84  ILE A CG1   1 ? 
ATOM   666  C CG2   . ILE A 1 84  ? 15.377  -6.942  14.676  1.000 19.674  0  84  ILE A CG2   1 ? 
ATOM   667  C CD1   . ILE A 1 84  ? 15.447  -5.111  12.217  1.000 22.256  0  84  ILE A CD1   1 ? 
ATOM   668  N N     . LEU A 1 85  ? 13.369  -6.356  17.804  1.000 26.240  0  85  LEU A N     1 ? 
ATOM   669  C CA    . LEU A 1 85  ? 13.717  -6.561  19.237  1.000 29.239  0  85  LEU A CA    1 ? 
ATOM   670  C C     . LEU A 1 85  ? 14.986  -7.409  19.308  1.000 27.006  0  85  LEU A C     1 ? 
ATOM   671  O O     . LEU A 1 85  ? 15.150  -8.322  18.475  1.000 24.316  0  85  LEU A O     1 ? 
ATOM   672  C CB    . LEU A 1 85  ? 12.554  -7.238  19.954  1.000 32.053  0  85  LEU A CB    1 ? 
ATOM   673  C CG    . LEU A 1 85  ? 11.382  -6.318  20.258  1.000 37.233  0  85  LEU A CG    1 ? 
ATOM   674  C CD1   . LEU A 1 85  ? 10.058  -7.059  20.139  1.000 38.757  0  85  LEU A CD1   1 ? 
ATOM   675  C CD2   . LEU A 1 85  ? 11.546  -5.693  21.630  1.000 35.396  0  85  LEU A CD2   1 ? 
ATOM   676  N N     . ASN A 1 86  ? 15.836  -7.106  20.275  1.000 28.431  0  86  ASN A N     1 ? 
ATOM   677  C CA    . ASN A 1 86  ? 17.102  -7.819  20.538  1.000 30.378  0  86  ASN A CA    1 ? 
ATOM   678  C C     . ASN A 1 86  ? 16.774  -9.139  21.264  1.000 32.000  0  86  ASN A C     1 ? 
ATOM   679  O O     . ASN A 1 86  ? 17.206  -9.293  22.413  1.000 31.808  0  86  ASN A O     1 ? 
ATOM   680  C CB    . ASN A 1 86  ? 18.026  -6.856  21.293  1.000 34.859  0  86  ASN A CB    1 ? 
ATOM   681  C CG    . ASN A 1 86  ? 19.442  -7.351  21.455  1.000 38.108  0  86  ASN A CG    1 ? 
ATOM   682  O OD1   . ASN A 1 86  ? 20.100  -7.013  22.437  1.000 39.816  0  86  ASN A OD1   1 ? 
ATOM   683  N ND2   . ASN A 1 86  ? 19.920  -8.133  20.504  1.000 35.537  0  86  ASN A ND2   1 ? 
ATOM   684  N N     . ILE A 1 87  ? 16.018  -10.036 20.616  1.000 27.933  0  87  ILE A N     1 ? 
ATOM   685  C CA    . ILE A 1 87  ? 15.516  -11.330 21.171  1.000 29.507  0  87  ILE A CA    1 ? 
ATOM   686  C C     . ILE A 1 87  ? 15.765  -12.434 20.143  1.000 30.038  0  87  ILE A C     1 ? 
ATOM   687  O O     . ILE A 1 87  ? 15.802  -12.121 18.915  1.000 24.353  0  87  ILE A O     1 ? 
ATOM   688  C CB    . ILE A 1 87  ? 14.028  -11.250 21.550  1.000 30.305  0  87  ILE A CB    1 ? 
ATOM   689  C CG1   . ILE A 1 87  ? 13.150  -11.042 20.313  1.000 31.618  0  87  ILE A CG1   1 ? 
ATOM   690  C CG2   . ILE A 1 87  ? 13.804  -10.163 22.594  1.000 33.032  0  87  ILE A CG2   1 ? 
ATOM   691  C CD1   . ILE A 1 87  ? 11.685  -11.193 20.565  1.000 32.185  0  87  ILE A CD1   1 ? 
ATOM   692  N N     . ALA A 1 88  ? 15.970  -13.662 20.636  1.000 27.448  0  88  ALA A N     1 ? 
ATOM   693  C CA    . ALA A 1 88  ? 16.011  -14.908 19.848  1.000 27.556  0  88  ALA A CA    1 ? 
ATOM   694  C C     . ALA A 1 88  ? 14.574  -15.382 19.650  1.000 26.524  0  88  ALA A C     1 ? 
ATOM   695  O O     . ALA A 1 88  ? 13.848  -15.477 20.657  1.000 27.523  0  88  ALA A O     1 ? 
ATOM   696  C CB    . ALA A 1 88  ? 16.833  -15.951 20.566  1.000 30.236  0  88  ALA A CB    1 ? 
ATOM   697  N N     . LYS A 1 89  ? 14.169  -15.646 18.409  1.000 24.052  0  89  LYS A N     1 ? 
ATOM   698  C CA    . LYS A 1 89  ? 12.746  -15.953 18.070  1.000 27.176  0  89  LYS A CA    1 ? 
ATOM   699  C C     . LYS A 1 89  ? 12.338  -17.255 18.774  1.000 26.533  0  89  LYS A C     1 ? 
ATOM   700  O O     . LYS A 1 89  ? 11.216  -17.305 19.315  1.000 25.054  0  89  LYS A O     1 ? 
ATOM   701  C CB    . LYS A 1 89  ? 12.527  -15.984 16.543  1.000 25.813  0  89  LYS A CB    1 ? 
ATOM   702  C CG    . LYS A 1 89  ? 12.812  -17.283 15.811  1.000 28.076  0  89  LYS A CG    1 ? 
ATOM   703  C CD    . LYS A 1 89  ? 12.663  -17.178 14.302  1.000 27.917  0  89  LYS A CD    1 ? 
ATOM   704  C CE    . LYS A 1 89  ? 13.280  -18.321 13.509  1.000 29.921  0  89  LYS A CE    1 ? 
ATOM   705  N NZ    . LYS A 1 89  ? 12.987  -19.634 14.130  1.000 33.108  0  89  LYS A NZ    1 ? 
ATOM   706  N N     . ASP A 1 90  ? 13.253  -18.218 18.860  1.000 28.892  0  90  ASP A N     1 ? 
ATOM   707  C CA    . ASP A 1 90  ? 12.976  -19.571 19.425  1.000 32.713  0  90  ASP A CA    1 ? 
ATOM   708  C C     . ASP A 1 90  ? 12.747  -19.482 20.943  1.000 31.985  0  90  ASP A C     1 ? 
ATOM   709  O O     . ASP A 1 90  ? 12.137  -20.405 21.477  1.000 37.622  0  90  ASP A O     1 ? 
ATOM   710  C CB    . ASP A 1 90  ? 14.084  -20.560 19.053  1.000 33.581  0  90  ASP A CB    1 ? 
ATOM   711  C CG    . ASP A 1 90  ? 14.073  -20.975 17.589  1.000 39.395  0  90  ASP A CG    1 ? 
ATOM   712  O OD1   . ASP A 1 90  ? 13.054  -20.727 16.913  1.000 41.410  0  90  ASP A OD1   1 ? 
ATOM   713  O OD2   . ASP A 1 90  ? 15.081  -21.552 17.139  1.000 42.546  0  90  ASP A OD2   1 ? 
ATOM   714  N N     . ASP A 1 91  ? 13.153  -18.390 21.593  1.000 31.094  0  91  ASP A N     1 ? 
ATOM   715  C CA    . ASP A 1 91  ? 13.059  -18.205 23.066  1.000 34.228  0  91  ASP A CA    1 ? 
ATOM   716  C C     . ASP A 1 91  ? 11.720  -17.599 23.477  1.000 34.828  0  91  ASP A C     1 ? 
ATOM   717  O O     . ASP A 1 91  ? 11.495  -17.520 24.681  1.000 37.146  0  91  ASP A O     1 ? 
ATOM   718  C CB    . ASP A 1 91  ? 14.142  -17.268 23.609  1.000 34.233  0  91  ASP A CB    1 ? 
ATOM   719  C CG    . ASP A 1 91  ? 15.513  -17.896 23.656  1.000 36.221  0  91  ASP A CG    1 ? 
ATOM   720  O OD1   . ASP A 1 91  ? 16.464  -17.188 24.037  1.000 41.596  0  91  ASP A OD1   1 ? 
ATOM   721  O OD2   . ASP A 1 91  ? 15.614  -19.073 23.304  1.000 33.924  0  91  ASP A OD2   1 ? 
ATOM   722  N N     . HIS A 1 92  ? 10.906  -17.106 22.536  1.000 33.064  0  92  HIS A N     1 ? 
ATOM   723  C CA    . HIS A 1 92  ? 9.683   -16.334 22.860  1.000 32.246  0  92  HIS A CA    1 ? 
ATOM   724  C C     . HIS A 1 92  ? 8.528   -16.728 21.925  1.000 34.954  0  92  HIS A C     1 ? 
ATOM   725  O O     . HIS A 1 92  ? 8.773   -17.216 20.779  1.000 37.275  0  92  HIS A O     1 ? 
ATOM   726  C CB    . HIS A 1 92  ? 9.985   -14.828 22.870  1.000 34.012  0  92  HIS A CB    1 ? 
ATOM   727  C CG    . HIS A 1 92  ? 11.192  -14.428 23.661  1.000 35.796  0  92  HIS A CG    1 ? 
ATOM   728  N ND1   . HIS A 1 92  ? 11.134  -14.122 25.016  1.000 40.064  0  92  HIS A ND1   1 ? 
ATOM   729  C CD2   . HIS A 1 92  ? 12.481  -14.234 23.290  1.000 33.500  0  92  HIS A CD2   1 ? 
ATOM   730  C CE1   . HIS A 1 92  ? 12.339  -13.774 25.438  1.000 39.202  0  92  HIS A CE1   1 ? 
ATOM   731  N NE2   . HIS A 1 92  ? 13.182  -13.851 24.398  1.000 36.097  0  92  HIS A NE2   1 ? 
ATOM   732  N N     . ASP A 1 93  ? 7.306   -16.591 22.425  1.000 31.755  0  93  ASP A N     1 ? 
ATOM   733  C CA    . ASP A 1 93  ? 6.055   -16.734 21.640  1.000 34.637  0  93  ASP A CA    1 ? 
ATOM   734  C C     . ASP A 1 93  ? 5.805   -15.432 20.874  1.000 30.423  0  93  ASP A C     1 ? 
ATOM   735  O O     . ASP A 1 93  ? 5.963   -14.353 21.430  1.000 29.158  0  93  ASP A O     1 ? 
ATOM   736  C CB    . ASP A 1 93  ? 4.885   -17.080 22.569  1.000 37.930  0  93  ASP A CB    1 ? 
ATOM   737  C CG    . ASP A 1 93  ? 3.579   -17.357 21.857  1.000 38.556  0  93  ASP A CG    1 ? 
ATOM   738  O OD1   . ASP A 1 93  ? 3.419   -18.497 21.341  1.000 45.683  0  93  ASP A OD1   1 ? 
ATOM   739  O OD2   . ASP A 1 93  ? 2.748   -16.436 21.805  1.000 36.333  0  93  ASP A OD2   1 ? 
ATOM   740  N N     . PRO A 1 94  ? 5.424   -15.483 19.573  1.000 32.092  0  94  PRO A N     1 ? 
ATOM   741  C CA    . PRO A 1 94  ? 5.213   -14.260 18.790  1.000 33.740  0  94  PRO A CA    1 ? 
ATOM   742  C C     . PRO A 1 94  ? 4.112   -13.381 19.398  1.000 36.521  0  94  PRO A C     1 ? 
ATOM   743  O O     . PRO A 1 94  ? 4.306   -12.181 19.536  1.000 34.298  0  94  PRO A O     1 ? 
ATOM   744  C CB    . PRO A 1 94  ? 4.823   -14.774 17.401  1.000 34.540  0  94  PRO A CB    1 ? 
ATOM   745  C CG    . PRO A 1 94  ? 4.341   -16.189 17.646  1.000 35.831  0  94  PRO A CG    1 ? 
ATOM   746  C CD    . PRO A 1 94  ? 5.193   -16.698 18.788  1.000 32.256  0  94  PRO A CD    1 ? 
ATOM   747  N N     . VAL A 1 95  ? 2.998   -14.004 19.802  1.000 37.422  0  95  VAL A N     1 ? 
ATOM   748  C CA    . VAL A 1 95  ? 1.863   -13.284 20.460  1.000 37.790  0  95  VAL A CA    1 ? 
ATOM   749  C C     . VAL A 1 95  ? 2.341   -12.712 21.799  1.000 35.680  0  95  VAL A C     1 ? 
ATOM   750  O O     . VAL A 1 95  ? 1.994   -11.572 22.058  1.000 34.373  0  95  VAL A O     1 ? 
ATOM   751  C CB    . VAL A 1 95  ? 0.619   -14.176 20.634  1.000 39.490  0  95  VAL A CB    1 ? 
ATOM   752  C CG1   . VAL A 1 95  ? -0.554  -13.375 21.170  1.000 40.034  0  95  VAL A CG1   1 ? 
ATOM   753  C CG2   . VAL A 1 95  ? 0.239   -14.868 19.327  1.000 39.187  0  95  VAL A CG2   1 ? 
ATOM   754  N N     . GLU A 1 96  ? 3.066   -13.503 22.625  1.000 38.421  0  96  GLU A N     1 ? 
ATOM   755  C CA    . GLU A 1 96  ? 3.762   -13.028 23.870  1.000 37.020  0  96  GLU A CA    1 ? 
ATOM   756  C C     . GLU A 1 96  ? 4.543   -11.754 23.557  1.000 33.946  0  96  GLU A C     1 ? 
ATOM   757  O O     . GLU A 1 96  ? 4.419   -10.768 24.310  1.000 31.600  0  96  GLU A O     1 ? 
ATOM   758  C CB    . GLU A 1 96  ? 4.743   -14.071 24.437  1.000 41.395  0  96  GLU A CB    1 ? 
ATOM   759  C CG    . GLU A 1 96  ? 5.629   -13.554 25.581  1.000 42.326  0  96  GLU A CG    1 ? 
ATOM   760  C CD    . GLU A 1 96  ? 6.874   -14.389 25.901  1.000 50.777  0  96  GLU A CD    1 ? 
ATOM   761  O OE1   . GLU A 1 96  ? 7.031   -15.498 25.339  1.000 51.140  0  96  GLU A OE1   1 ? 
ATOM   762  O OE2   . GLU A 1 96  ? 7.703   -13.925 26.715  1.000 56.751  0  96  GLU A OE2   1 ? 
ATOM   763  N N     . VAL A 1 97  ? 5.393   -11.794 22.528  1.000 33.221  0  97  VAL A N     1 ? 
ATOM   764  C CA    . VAL A 1 97  ? 6.243   -10.618 22.190  1.000 34.364  0  97  VAL A CA    1 ? 
ATOM   765  C C     . VAL A 1 97  ? 5.326   -9.482  21.725  1.000 30.342  0  97  VAL A C     1 ? 
ATOM   766  O O     . VAL A 1 97  ? 5.529   -8.362  22.149  1.000 26.865  0  97  VAL A O     1 ? 
ATOM   767  C CB    . VAL A 1 97  ? 7.326   -10.932 21.151  1.000 35.559  0  97  VAL A CB    1 ? 
ATOM   768  C CG1   . VAL A 1 97  ? 8.074   -9.667  20.771  1.000 35.347  0  97  VAL A CG1   1 ? 
ATOM   769  C CG2   . VAL A 1 97  ? 8.298   -11.995 21.650  1.000 36.075  0  97  VAL A CG2   1 ? 
ATOM   770  N N     . LYS A 1 98  ? 4.309   -9.771  20.922  1.000 31.615  0  98  LYS A N     1 ? 
ATOM   771  C CA    . LYS A 1 98  ? 3.366   -8.700  20.495  1.000 33.482  0  98  LYS A CA    1 ? 
ATOM   772  C C     . LYS A 1 98  ? 2.601   -8.190  21.729  1.000 37.692  0  98  LYS A C     1 ? 
ATOM   773  O O     . LYS A 1 98  ? 2.254   -6.988  21.743  1.000 33.150  0  98  LYS A O     1 ? 
ATOM   774  C CB    . LYS A 1 98  ? 2.433   -9.190  19.389  1.000 36.528  0  98  LYS A CB    1 ? 
ATOM   775  C CG    . LYS A 1 98  ? 2.922   -8.914  17.973  1.000 33.626  0  98  LYS A CG    1 ? 
ATOM   776  C CD    . LYS A 1 98  ? 1.844   -9.144  16.920  1.000 34.527  0  98  LYS A CD    1 ? 
ATOM   777  C CE    . LYS A 1 98  ? 1.530   -10.605 16.690  1.000 33.998  0  98  LYS A CE    1 ? 
ATOM   778  N NZ    . LYS A 1 98  ? 0.664   -10.803 15.503  1.000 34.839  0  98  LYS A NZ    1 ? 
ATOM   779  N N     . LYS A 1 99  ? 2.346   -9.058  22.727  1.000 35.072  0  99  LYS A N     1 ? 
ATOM   780  C CA    . LYS A 1 99  ? 1.668   -8.654  23.995  1.000 37.143  0  99  LYS A CA    1 ? 
ATOM   781  C C     . LYS A 1 99  ? 2.515   -7.593  24.702  1.000 32.836  0  99  LYS A C     1 ? 
ATOM   782  O O     . LYS A 1 99  ? 1.962   -6.577  25.127  1.000 35.527  0  99  LYS A O     1 ? 
ATOM   783  C CB    . LYS A 1 99  ? 1.425   -9.855  24.913  1.000 39.974  0  99  LYS A CB    1 ? 
ATOM   784  C CG    . LYS A 1 99  ? 0.330   -9.640  25.945  1.000 42.330  0  99  LYS A CG    1 ? 
ATOM   785  C CD    . LYS A 1 99  ? 0.287   -10.705 27.004  1.000 46.400  0  99  LYS A CD    1 ? 
ATOM   786  C CE    . LYS A 1 99  ? -0.854  -10.505 27.982  1.000 50.240  0  99  LYS A CE    1 ? 
ATOM   787  N NZ    . LYS A 1 99  ? -0.609  -9.355  28.890  1.000 47.909  0  99  LYS A NZ    1 ? 
ATOM   788  N N     . TRP A 1 100 ? 3.821   -7.798  24.803  1.000 36.161  0  100 TRP A N     1 ? 
ATOM   789  C CA    . TRP A 1 100 ? 4.724   -6.796  25.430  1.000 33.546  0  100 TRP A CA    1 ? 
ATOM   790  C C     . TRP A 1 100 ? 4.417   -5.427  24.840  1.000 38.413  0  100 TRP A C     1 ? 
ATOM   791  O O     . TRP A 1 100 ? 4.194   -4.474  25.605  1.000 36.664  0  100 TRP A O     1 ? 
ATOM   792  C CB    . TRP A 1 100 ? 6.188   -7.131  25.201  1.000 35.868  0  100 TRP A CB    1 ? 
ATOM   793  C CG    . TRP A 1 100 ? 6.615   -8.486  25.673  1.000 37.194  0  100 TRP A CG    1 ? 
ATOM   794  C CD1   . TRP A 1 100 ? 6.015   -9.278  26.612  1.000 37.472  0  100 TRP A CD1   1 ? 
ATOM   795  C CD2   . TRP A 1 100 ? 7.828   -9.152  25.302  1.000 36.394  0  100 TRP A CD2   1 ? 
ATOM   796  N NE1   . TRP A 1 100 ? 6.758   -10.407 26.818  1.000 36.247  0  100 TRP A NE1   1 ? 
ATOM   797  C CE2   . TRP A 1 100 ? 7.877   -10.356 26.031  1.000 35.360  0  100 TRP A CE2   1 ? 
ATOM   798  C CE3   . TRP A 1 100 ? 8.885   -8.838  24.439  1.000 37.699  0  100 TRP A CE3   1 ? 
ATOM   799  C CZ2   . TRP A 1 100 ? 8.923   -11.262 25.887  1.000 37.635  0  100 TRP A CZ2   1 ? 
ATOM   800  C CZ3   . TRP A 1 100 ? 9.912   -9.739  24.291  1.000 39.242  0  100 TRP A CZ3   1 ? 
ATOM   801  C CH2   . TRP A 1 100 ? 9.936   -10.932 25.019  1.000 36.620  0  100 TRP A CH2   1 ? 
ATOM   802  N N     . ILE A 1 101 ? 4.402   -5.346  23.505  1.000 34.065  0  101 ILE A N     1 ? 
ATOM   803  C CA    . ILE A 1 101 ? 4.289   -4.049  22.788  1.000 33.052  0  101 ILE A CA    1 ? 
ATOM   804  C C     . ILE A 1 101 ? 2.895   -3.474  23.055  1.000 32.708  0  101 ILE A C     1 ? 
ATOM   805  O O     . ILE A 1 101 ? 2.810   -2.275  23.371  1.000 31.363  0  101 ILE A O     1 ? 
ATOM   806  C CB    . ILE A 1 101 ? 4.583   -4.207  21.282  1.000 29.322  0  101 ILE A CB    1 ? 
ATOM   807  C CG1   . ILE A 1 101 ? 5.943   -4.862  21.026  1.000 29.696  0  101 ILE A CG1   1 ? 
ATOM   808  C CG2   . ILE A 1 101 ? 4.456   -2.866  20.579  1.000 28.824  0  101 ILE A CG2   1 ? 
ATOM   809  C CD1   . ILE A 1 101 ? 7.139   -4.091  21.559  1.000 28.853  0  101 ILE A CD1   1 ? 
ATOM   810  N N     . ARG A 1 102 ? 1.853   -4.302  22.947  1.000 33.673  0  102 ARG A N     1 ? 
ATOM   811  C CA    . ARG A 1 102 ? 0.436   -3.901  23.191  1.000 37.662  0  102 ARG A CA    1 ? 
ATOM   812  C C     . ARG A 1 102 ? 0.324   -3.266  24.584  1.000 39.349  0  102 ARG A C     1 ? 
ATOM   813  O O     . ARG A 1 102 ? -0.261  -2.175  24.686  1.000 38.779  0  102 ARG A O     1 ? 
ATOM   814  C CB    . ARG A 1 102 ? -0.500  -5.110  23.038  1.000 40.941  0  102 ARG A CB    1 ? 
ATOM   815  C CG    . ARG A 1 102 ? -1.974  -4.754  22.865  1.000 44.909  0  102 ARG A CG    1 ? 
ATOM   816  C CD    . ARG A 1 102 ? -2.772  -4.578  24.157  1.000 51.132  0  102 ARG A CD    1 ? 
ATOM   817  N NE    . ARG A 1 102 ? -2.608  -5.667  25.116  1.000 54.406  0  102 ARG A NE    1 ? 
ATOM   818  C CZ    . ARG A 1 102 ? -3.172  -6.881  25.026  1.000 59.390  0  102 ARG A CZ    1 ? 
ATOM   819  N NH1   . ARG A 1 102 ? -3.938  -7.202  23.997  1.000 60.433  0  102 ARG A NH1   1 ? 
ATOM   820  N NH2   . ARG A 1 102 ? -2.937  -7.785  25.963  1.000 57.903  0  102 ARG A NH2   1 ? 
ATOM   821  N N     . ASP A 1 103 ? 0.857   -3.945  25.607  1.000 42.838  0  103 ASP A N     1 ? 
ATOM   822  C CA    . ASP A 1 103 ? 0.808   -3.517  27.034  1.000 42.619  0  103 ASP A CA    1 ? 
ATOM   823  C C     . ASP A 1 103 ? 1.702   -2.289  27.222  1.000 39.813  0  103 ASP A C     1 ? 
ATOM   824  O O     . ASP A 1 103 ? 1.325   -1.417  28.017  1.000 41.629  0  103 ASP A O     1 ? 
ATOM   825  C CB    . ASP A 1 103 ? 1.229   -4.640  27.992  1.000 43.186  0  103 ASP A CB    1 ? 
ATOM   826  C CG    . ASP A 1 103 ? 0.294   -5.840  28.003  1.000 43.113  0  103 ASP A CG    1 ? 
ATOM   827  O OD1   . ASP A 1 103 ? 0.644   -6.815  28.671  1.000 43.903  0  103 ASP A OD1   1 ? 
ATOM   828  O OD2   . ASP A 1 103 ? -0.773  -5.794  27.321  1.000 43.049  0  103 ASP A OD2   1 ? 
ATOM   829  N N     . ALA A 1 104 ? 2.818   -2.200  26.492  1.000 35.719  0  104 ALA A N     1 ? 
ATOM   830  C CA    . ALA A 1 104 ? 3.695   -1.007  26.499  1.000 37.392  0  104 ALA A CA    1 ? 
ATOM   831  C C     . ALA A 1 104 ? 2.879   0.223   26.083  1.000 41.052  0  104 ALA A C     1 ? 
ATOM   832  O O     . ALA A 1 104 ? 3.144   1.323   26.631  1.000 45.773  0  104 ALA A O     1 ? 
ATOM   833  C CB    . ALA A 1 104 ? 4.883   -1.224  25.607  1.000 39.224  0  104 ALA A CB    1 ? 
ATOM   834  N N     . LEU A 1 105 ? 1.902   0.044   25.182  1.000 40.579  0  105 LEU A N     1 ? 
ATOM   835  C CA    . LEU A 1 105 ? 1.156   1.153   24.509  1.000 43.943  0  105 LEU A CA    1 ? 
ATOM   836  C C     . LEU A 1 105 ? -0.308  1.196   24.977  1.000 49.282  0  105 LEU A C     1 ? 
ATOM   837  O O     . LEU A 1 105 ? -1.076  2.032   24.434  1.000 48.432  0  105 LEU A O     1 ? 
ATOM   838  C CB    . LEU A 1 105 ? 1.206   0.941   22.992  1.000 43.009  0  105 LEU A CB    1 ? 
ATOM   839  C CG    . LEU A 1 105 ? 2.571   1.138   22.332  1.000 43.907  0  105 LEU A CG    1 ? 
ATOM   840  C CD1   . LEU A 1 105 ? 2.487   0.827   20.846  1.000 41.591  0  105 LEU A CD1   1 ? 
ATOM   841  C CD2   . LEU A 1 105 ? 3.094   2.550   22.559  1.000 40.777  0  105 LEU A CD2   1 ? 
ATOM   842  N N     . LYS A 1 106 ? -0.696  0.318   25.907  1.000 54.232  0  106 LYS A N     1 ? 
ATOM   843  C CA    . LYS A 1 106 ? -2.107  0.157   26.360  1.000 62.077  0  106 LYS A CA    1 ? 
ATOM   844  C C     . LYS A 1 106 ? -2.744  1.548   26.500  1.000 62.492  0  106 LYS A C     1 ? 
ATOM   845  O O     . LYS A 1 106 ? -3.843  1.740   25.958  1.000 63.729  0  106 LYS A O     1 ? 
ATOM   846  C CB    . LYS A 1 106 ? -2.172  -0.627  27.679  1.000 65.269  0  106 LYS A CB    1 ? 
ATOM   847  C CG    . LYS A 1 106 ? -3.249  -1.704  27.746  1.000 70.833  0  106 LYS A CG    1 ? 
ATOM   848  C CD    . LYS A 1 106 ? -4.601  -1.211  28.224  1.000 74.304  0  106 LYS A CD    1 ? 
ATOM   849  C CE    . LYS A 1 106 ? -5.554  -2.340  28.557  1.000 75.858  0  106 LYS A CE    1 ? 
ATOM   850  N NZ    . LYS A 1 106 ? -6.879  -1.832  28.985  1.000 79.542  0  106 LYS A NZ    1 ? 
ATOM   851  N N     . ASP A 1 107 ? -2.032  2.494   27.132  1.000 64.923  0  107 ASP A N     1 ? 
ATOM   852  C CA    . ASP A 1 107 ? -2.576  3.800   27.597  1.000 68.141  0  107 ASP A CA    1 ? 
ATOM   853  C C     . ASP A 1 107 ? -2.011  4.952   26.753  1.000 63.575  0  107 ASP A C     1 ? 
ATOM   854  O O     . ASP A 1 107 ? -1.959  6.083   27.269  1.000 58.719  0  107 ASP A O     1 ? 
ATOM   855  C CB    . ASP A 1 107 ? -2.289  3.989   29.090  1.000 73.566  0  107 ASP A CB    1 ? 
ATOM   856  C CG    . ASP A 1 107 ? -2.808  2.843   29.947  1.000 75.241  0  107 ASP A CG    1 ? 
ATOM   857  O OD1   . ASP A 1 107 ? -3.792  2.190   29.522  1.000 74.652  0  107 ASP A OD1   1 ? 
ATOM   858  O OD2   . ASP A 1 107 ? -2.220  2.601   31.023  1.000 82.070  0  107 ASP A OD2   1 ? 
ATOM   859  N N     . TYR A 1 108 ? -1.613  4.673   25.505  1.000 60.571  0  108 TYR A N     1 ? 
ATOM   860  C CA    . TYR A 1 108 ? -1.253  5.685   24.473  1.000 57.277  0  108 TYR A CA    1 ? 
ATOM   861  C C     . TYR A 1 108 ? -2.488  5.906   23.593  1.000 54.442  0  108 TYR A C     1 ? 
ATOM   862  O O     . TYR A 1 108 ? -3.123  4.900   23.194  1.000 54.723  0  108 TYR A O     1 ? 
ATOM   863  C CB    . TYR A 1 108 ? -0.022  5.238   23.671  1.000 54.855  0  108 TYR A CB    1 ? 
ATOM   864  C CG    . TYR A 1 108 ? 0.613   6.317   22.829  1.000 53.541  0  108 TYR A CG    1 ? 
ATOM   865  C CD1   . TYR A 1 108 ? 1.597   7.140   23.346  1.000 51.617  0  108 TYR A CD1   1 ? 
ATOM   866  C CD2   . TYR A 1 108 ? 0.220   6.528   21.512  1.000 54.587  0  108 TYR A CD2   1 ? 
ATOM   867  C CE1   . TYR A 1 108 ? 2.182   8.137   22.581  1.000 51.490  0  108 TYR A CE1   1 ? 
ATOM   868  C CE2   . TYR A 1 108 ? 0.794   7.523   20.733  1.000 52.725  0  108 TYR A CE2   1 ? 
ATOM   869  C CZ    . TYR A 1 108 ? 1.780   8.331   21.269  1.000 52.766  0  108 TYR A CZ    1 ? 
ATOM   870  O OH    . TYR A 1 108 ? 2.359   9.308   20.512  1.000 48.336  0  108 TYR A OH    1 ? 
ATOM   871  N N     . GLY A 1 109 ? -2.847  7.174   23.360  1.000 54.537  0  109 GLY A N     1 ? 
ATOM   872  C CA    . GLY A 1 109 ? -4.030  7.588   22.578  1.000 49.772  0  109 GLY A CA    1 ? 
ATOM   873  C C     . GLY A 1 109 ? -5.250  6.756   22.925  1.000 48.686  0  109 GLY A C     1 ? 
ATOM   874  O O     . GLY A 1 109 ? -5.471  6.510   24.121  1.000 45.547  0  109 GLY A O     1 ? 
ATOM   875  N N     . ASN A 1 110 ? -5.992  6.304   21.911  1.000 48.433  0  110 ASN A N     1 ? 
ATOM   876  C CA    . ASN A 1 110 ? -7.246  5.514   22.060  1.000 51.383  0  110 ASN A CA    1 ? 
ATOM   877  C C     . ASN A 1 110 ? -6.924  4.017   22.133  1.000 50.745  0  110 ASN A C     1 ? 
ATOM   878  O O     . ASN A 1 110 ? -7.744  3.221   21.635  1.000 58.054  0  110 ASN A O     1 ? 
ATOM   879  C CB    . ASN A 1 110 ? -8.223  5.753   20.907  1.000 50.283  0  110 ASN A CB    1 ? 
ATOM   880  C CG    . ASN A 1 110 ? -8.536  7.212   20.679  1.000 57.333  0  110 ASN A CG    1 ? 
ATOM   881  O OD1   . ASN A 1 110 ? -8.828  7.616   19.555  1.000 60.285  0  110 ASN A OD1   1 ? 
ATOM   882  N ND2   . ASN A 1 110 ? -8.490  8.004   21.739  1.000 62.158  0  110 ASN A ND2   1 ? 
ATOM   883  N N     . GLY A 1 111 ? -5.781  3.651   22.717  1.000 50.029  0  111 GLY A N     1 ? 
ATOM   884  C CA    . GLY A 1 111 ? -5.430  2.255   23.037  1.000 52.971  0  111 GLY A CA    1 ? 
ATOM   885  C C     . GLY A 1 111 ? -4.654  1.568   21.922  1.000 53.689  0  111 GLY A C     1 ? 
ATOM   886  O O     . GLY A 1 111 ? -4.545  2.137   20.813  1.000 52.118  0  111 GLY A O     1 ? 
ATOM   887  N N     . ALA A 1 112 ? -4.122  0.385   22.225  1.000 51.668  0  112 ALA A N     1 ? 
ATOM   888  C CA    . ALA A 1 112 ? -3.382  -0.494  21.297  1.000 48.342  0  112 ALA A CA    1 ? 
ATOM   889  C C     . ALA A 1 112 ? -4.200  -1.768  21.053  1.000 51.087  0  112 ALA A C     1 ? 
ATOM   890  O O     . ALA A 1 112 ? -5.218  -1.974  21.737  1.000 54.493  0  112 ALA A O     1 ? 
ATOM   891  C CB    . ALA A 1 112 ? -2.031  -0.798  21.871  1.000 46.431  0  112 ALA A CB    1 ? 
ATOM   892  N N     . GLU A 1 113 ? -3.768  -2.594  20.108  1.000 47.742  0  113 GLU A N     1 ? 
ATOM   893  C CA    . GLU A 1 113 ? -4.478  -3.824  19.681  1.000 44.679  0  113 GLU A CA    1 ? 
ATOM   894  C C     . GLU A 1 113 ? -3.453  -4.758  19.048  1.000 42.854  0  113 GLU A C     1 ? 
ATOM   895  O O     . GLU A 1 113 ? -2.558  -4.243  18.350  1.000 39.855  0  113 GLU A O     1 ? 
ATOM   896  C CB    . GLU A 1 113 ? -5.578  -3.458  18.687  1.000 45.928  0  113 GLU A CB    1 ? 
ATOM   897  C CG    . GLU A 1 113 ? -6.659  -4.501  18.555  1.000 51.201  0  113 GLU A CG    1 ? 
ATOM   898  C CD    . GLU A 1 113 ? -8.047  -3.893  18.451  1.000 59.397  0  113 GLU A CD    1 ? 
ATOM   899  O OE1   . GLU A 1 113 ? -8.993  -4.474  19.040  1.000 68.655  0  113 GLU A OE1   1 ? 
ATOM   900  O OE2   . GLU A 1 113 ? -8.175  -2.822  17.813  1.000 55.916  0  113 GLU A OE2   1 ? 
ATOM   901  N N     . ILE A 1 114 ? -3.588  -6.060  19.282  1.000 35.914  0  114 ILE A N     1 ? 
ATOM   902  C CA    . ILE A 1 114 ? -2.758  -7.100  18.636  1.000 38.082  0  114 ILE A CA    1 ? 
ATOM   903  C C     . ILE A 1 114 ? -3.487  -7.547  17.371  1.000 40.524  0  114 ILE A C     1 ? 
ATOM   904  O O     . ILE A 1 114 ? -4.656  -8.001  17.467  1.000 40.468  0  114 ILE A O     1 ? 
ATOM   905  C CB    . ILE A 1 114 ? -2.445  -8.250  19.601  1.000 37.040  0  114 ILE A CB    1 ? 
ATOM   906  C CG1   . ILE A 1 114 ? -1.476  -7.786  20.689  1.000 36.298  0  114 ILE A CG1   1 ? 
ATOM   907  C CG2   . ILE A 1 114 ? -1.905  -9.460  18.850  1.000 40.283  0  114 ILE A CG2   1 ? 
ATOM   908  C CD1   . ILE A 1 114 ? -1.360  -8.731  21.853  1.000 36.472  0  114 ILE A CD1   1 ? 
ATOM   909  N N     . ARG A 1 115 ? -2.851  -7.363  16.218  1.000 34.159  0  115 ARG A N     1 ? 
ATOM   910  C CA    . ARG A 1 115 ? -3.410  -7.797  14.917  1.000 34.456  0  115 ARG A CA    1 ? 
ATOM   911  C C     . ARG A 1 115 ? -2.624  -9.014  14.441  1.000 31.937  0  115 ARG A C     1 ? 
ATOM   912  O O     . ARG A 1 115 ? -1.596  -9.316  15.054  1.000 30.185  0  115 ARG A O     1 ? 
ATOM   913  C CB    . ARG A 1 115 ? -3.374  -6.619  13.943  1.000 41.953  0  115 ARG A CB    1 ? 
ATOM   914  C CG    . ARG A 1 115 ? -4.229  -5.437  14.382  1.000 45.272  0  115 ARG A CG    1 ? 
ATOM   915  C CD    . ARG A 1 115 ? -5.375  -5.231  13.415  1.000 49.793  0  115 ARG A CD    1 ? 
ATOM   916  N NE    . ARG A 1 115 ? -6.268  -4.137  13.778  1.000 50.429  0  115 ARG A NE    1 ? 
ATOM   917  C CZ    . ARG A 1 115 ? -6.392  -2.989  13.118  1.000 53.635  0  115 ARG A CZ    1 ? 
ATOM   918  N NH1   . ARG A 1 115 ? -5.657  -2.739  12.043  1.000 56.272  0  115 ARG A NH1   1 ? 
ATOM   919  N NH2   . ARG A 1 115 ? -7.256  -2.084  13.545  1.000 56.112  0  115 ARG A NH2   1 ? 
ATOM   920  N N     . ARG A 1 116 ? -3.082  -9.670  13.373  1.000 26.396  0  116 ARG A N     1 ? 
ATOM   921  C CA    . ARG A 1 116 ? -2.446  -10.892 12.849  1.000 32.117  0  116 ARG A CA    1 ? 
ATOM   922  C C     . ARG A 1 116 ? -0.958  -10.597 12.612  1.000 30.353  0  116 ARG A C     1 ? 
ATOM   923  O O     . ARG A 1 116 ? -0.122  -11.457 12.963  1.000 29.991  0  116 ARG A O     1 ? 
ATOM   924  C CB    . ARG A 1 116 ? -3.185  -11.342 11.589  1.000 39.770  0  116 ARG A CB    1 ? 
ATOM   925  C CG    . ARG A 1 116 ? -2.561  -12.531 10.869  1.000 51.760  0  116 ARG A CG    1 ? 
ATOM   926  C CD    . ARG A 1 116 ? -2.766  -12.414 9.360   1.000 62.928  0  116 ARG A CD    1 ? 
ATOM   927  N NE    . ARG A 1 116 ? -2.188  -13.516 8.592   1.000 71.850  0  116 ARG A NE    1 ? 
ATOM   928  C CZ    . ARG A 1 116 ? -2.717  -14.735 8.482   1.000 75.692  0  116 ARG A CZ    1 ? 
ATOM   929  N NH1   . ARG A 1 116 ? -3.846  -15.035 9.104   1.000 79.258  0  116 ARG A NH1   1 ? 
ATOM   930  N NH2   . ARG A 1 116 ? -2.112  -15.654 7.747   1.000 79.361  0  116 ARG A NH2   1 ? 
ATOM   931  N N     . SER A 1 117 ? -0.647  -9.416  12.068  1.000 30.218  0  117 SER A N     1 ? 
ATOM   932  C CA    . SER A 1 117 ? 0.688   -9.061  11.508  1.000 31.724  0  117 SER A CA    1 ? 
ATOM   933  C C     . SER A 1 117 ? 1.320   -7.852  12.210  1.000 27.745  0  117 SER A C     1 ? 
ATOM   934  O O     . SER A 1 117 ? 2.462   -7.456  11.831  1.000 28.907  0  117 SER A O     1 ? 
ATOM   935  C CB    . SER A 1 117 ? 0.576   -8.826  10.037  1.000 33.006  0  117 SER A CB    1 ? 
ATOM   936  O OG    . SER A 1 117 ? 0.189   -10.027 9.379   1.000 39.104  0  117 SER A OG    1 ? 
ATOM   937  N N     . CYS A 1 118 ? 0.664   -7.275  13.206  1.000 26.555  0  118 CYS A N     1 ? 
ATOM   938  C CA    . CYS A 1 118 ? 1.201   -6.071  13.885  1.000 25.344  0  118 CYS A CA    1 ? 
ATOM   939  C C     . CYS A 1 118 ? 0.461   -5.797  15.198  1.000 28.578  0  118 CYS A C     1 ? 
ATOM   940  O O     . CYS A 1 118 ? -0.543  -6.481  15.495  1.000 28.946  0  118 CYS A O     1 ? 
ATOM   941  C CB    . CYS A 1 118 ? 1.097   -4.840  12.992  1.000 30.691  0  118 CYS A CB    1 ? 
ATOM   942  S SG    . CYS A 1 118 ? -0.611  -4.383  12.578  1.000 32.956  0  118 CYS A SG    1 ? 
ATOM   943  N N     . VAL A 1 119 ? 1.025   -4.881  15.967  1.000 28.811  0  119 VAL A N     1 ? 
ATOM   944  C CA    . VAL A 1 119 ? 0.359   -4.150  17.063  1.000 33.916  0  119 VAL A CA    1 ? 
ATOM   945  C C     . VAL A 1 119 ? -0.011  -2.786  16.499  1.000 32.346  0  119 VAL A C     1 ? 
ATOM   946  O O     . VAL A 1 119 ? 0.900   -2.080  16.046  1.000 35.082  0  119 VAL A O     1 ? 
ATOM   947  C CB    . VAL A 1 119 ? 1.289   -4.027  18.282  1.000 35.750  0  119 VAL A CB    1 ? 
ATOM   948  C CG1   . VAL A 1 119 ? 0.778   -3.008  19.294  1.000 43.048  0  119 VAL A CG1   1 ? 
ATOM   949  C CG2   . VAL A 1 119 ? 1.514   -5.384  18.929  1.000 36.307  0  119 VAL A CG2   1 ? 
ATOM   950  N N     . THR A 1 120 ? -1.292  -2.450  16.490  1.000 30.648  0  120 THR A N     1 ? 
ATOM   951  C CA    . THR A 1 120 ? -1.785  -1.135  16.001  1.000 36.226  0  120 THR A CA    1 ? 
ATOM   952  C C     . THR A 1 120 ? -2.119  -0.269  17.211  1.000 38.957  0  120 THR A C     1 ? 
ATOM   953  O O     . THR A 1 120 ? -2.774  -0.799  18.143  1.000 32.940  0  120 THR A O     1 ? 
ATOM   954  C CB    . THR A 1 120 ? -3.008  -1.276  15.081  1.000 40.453  0  120 THR A CB    1 ? 
ATOM   955  O OG1   . THR A 1 120 ? -2.647  -2.024  13.919  1.000 41.985  0  120 THR A OG1   1 ? 
ATOM   956  C CG2   . THR A 1 120 ? -3.560  0.064   14.648  1.000 39.026  0  120 THR A CG2   1 ? 
ATOM   957  N N     . VAL A 1 121 ? -1.674  0.987   17.206  1.000 39.151  0  121 VAL A N     1 ? 
ATOM   958  C CA    . VAL A 1 121 ? -2.034  1.995   18.245  1.000 44.228  0  121 VAL A CA    1 ? 
ATOM   959  C C     . VAL A 1 121 ? -2.824  3.130   17.580  1.000 45.459  0  121 VAL A C     1 ? 
ATOM   960  O O     . VAL A 1 121 ? -2.377  3.651   16.538  1.000 45.235  0  121 VAL A O     1 ? 
ATOM   961  C CB    . VAL A 1 121 ? -0.793  2.512   18.992  1.000 47.504  0  121 VAL A CB    1 ? 
ATOM   962  C CG1   . VAL A 1 121 ? 0.352   2.792   18.047  1.000 50.048  0  121 VAL A CG1   1 ? 
ATOM   963  C CG2   . VAL A 1 121 ? -1.110  3.740   19.838  1.000 50.232  0  121 VAL A CG2   1 ? 
ATOM   964  N N     . PHE A 1 122 ? -3.971  3.484   18.165  1.000 45.147  0  122 PHE A N     1 ? 
ATOM   965  C CA    . PHE A 1 122 ? -4.962  4.428   17.591  1.000 44.616  0  122 PHE A CA    1 ? 
ATOM   966  C C     . PHE A 1 122 ? -4.728  5.840   18.151  1.000 45.128  0  122 PHE A C     1 ? 
ATOM   967  O O     . PHE A 1 122 ? -4.449  5.988   19.353  1.000 49.222  0  122 PHE A O     1 ? 
ATOM   968  C CB    . PHE A 1 122 ? -6.366  3.915   17.880  1.000 44.255  0  122 PHE A CB    1 ? 
ATOM   969  C CG    . PHE A 1 122 ? -6.666  2.584   17.246  1.000 47.009  0  122 PHE A CG    1 ? 
ATOM   970  C CD1   . PHE A 1 122 ? -7.044  2.505   15.914  1.000 46.650  0  122 PHE A CD1   1 ? 
ATOM   971  C CD2   . PHE A 1 122 ? -6.555  1.412   17.977  1.000 49.062  0  122 PHE A CD2   1 ? 
ATOM   972  C CE1   . PHE A 1 122 ? -7.338  1.279   15.338  1.000 53.919  0  122 PHE A CE1   1 ? 
ATOM   973  C CE2   . PHE A 1 122 ? -6.835  0.184   17.399  1.000 53.497  0  122 PHE A CE2   1 ? 
ATOM   974  C CZ    . PHE A 1 122 ? -7.231  0.120   16.081  1.000 55.467  0  122 PHE A CZ    1 ? 
ATOM   975  N N     . LYS A 1 123 ? -4.811  6.842   17.278  1.000 43.999  0  123 LYS A N     1 ? 
ATOM   976  C CA    . LYS A 1 123 ? -4.805  8.281   17.632  1.000 45.085  0  123 LYS A CA    1 ? 
ATOM   977  C C     . LYS A 1 123 ? -5.706  9.025   16.647  1.000 46.947  0  123 LYS A C     1 ? 
ATOM   978  O O     . LYS A 1 123 ? -6.241  8.417   15.721  1.000 38.597  0  123 LYS A O     1 ? 
ATOM   979  C CB    . LYS A 1 123 ? -3.369  8.807   17.694  1.000 46.004  0  123 LYS A CB    1 ? 
ATOM   980  C CG    . LYS A 1 123 ? -2.796  8.870   19.108  1.000 49.271  0  123 LYS A CG    1 ? 
ATOM   981  C CD    . LYS A 1 123 ? -1.468  9.590   19.207  1.000 53.619  0  123 LYS A CD    1 ? 
ATOM   982  C CE    . LYS A 1 123 ? -1.575  11.095  19.063  1.000 55.442  0  123 LYS A CE    1 ? 
ATOM   983  N NZ    . LYS A 1 123 ? -1.540  11.775  20.381  1.000 57.272  0  123 LYS A NZ    1 ? 
ATOM   984  N N     . PRO A 1 124 ? -5.993  10.332  16.878  1.000 53.939  0  124 PRO A N     1 ? 
ATOM   985  C CA    . PRO A 1 124 ? -7.015  11.034  16.103  1.000 49.359  0  124 PRO A CA    1 ? 
ATOM   986  C C     . PRO A 1 124 ? -6.570  11.277  14.653  1.000 44.960  0  124 PRO A C     1 ? 
ATOM   987  O O     . PRO A 1 124 ? -5.601  11.969  14.455  1.000 47.963  0  124 PRO A O     1 ? 
ATOM   988  C CB    . PRO A 1 124 ? -7.228  12.366  16.856  1.000 53.555  0  124 PRO A CB    1 ? 
ATOM   989  C CG    . PRO A 1 124 ? -6.476  12.204  18.183  1.000 57.356  0  124 PRO A CG    1 ? 
ATOM   990  C CD    . PRO A 1 124 ? -5.388  11.186  17.914  1.000 53.085  0  124 PRO A CD    1 ? 
ATOM   991  N N     . GLY A 1 125 ? -7.316  10.734  13.685  1.000 42.634  0  125 GLY A N     1 ? 
ATOM   992  C CA    . GLY A 1 125 ? -7.036  10.885  12.244  1.000 39.915  0  125 GLY A CA    1 ? 
ATOM   993  C C     . GLY A 1 125 ? -5.929  9.952   11.734  1.000 41.169  0  125 GLY A C     1 ? 
ATOM   994  O O     . GLY A 1 125 ? -5.640  9.997   10.531  1.000 36.764  0  125 GLY A O     1 ? 
ATOM   995  N N     . TYR A 1 126 ? -5.312  9.123   12.580  1.000 41.761  0  126 TYR A N     1 ? 
ATOM   996  C CA    . TYR A 1 126 ? -4.272  8.161   12.122  1.000 38.868  0  126 TYR A CA    1 ? 
ATOM   997  C C     . TYR A 1 126 ? -4.036  7.054   13.151  1.000 42.019  0  126 TYR A C     1 ? 
ATOM   998  O O     . TYR A 1 126 ? -4.313  7.228   14.360  1.000 33.283  0  126 TYR A O     1 ? 
ATOM   999  C CB    . TYR A 1 126 ? -2.978  8.906   11.796  1.000 42.833  0  126 TYR A CB    1 ? 
ATOM   1000 C CG    . TYR A 1 126 ? -2.211  9.411   12.991  1.000 46.290  0  126 TYR A CG    1 ? 
ATOM   1001 C CD1   . TYR A 1 126 ? -2.438  10.674  13.519  1.000 49.174  0  126 TYR A CD1   1 ? 
ATOM   1002 C CD2   . TYR A 1 126 ? -1.234  8.628   13.585  1.000 50.242  0  126 TYR A CD2   1 ? 
ATOM   1003 C CE1   . TYR A 1 126 ? -1.711  11.148  14.602  1.000 48.599  0  126 TYR A CE1   1 ? 
ATOM   1004 C CE2   . TYR A 1 126 ? -0.491  9.088   14.658  1.000 49.247  0  126 TYR A CE2   1 ? 
ATOM   1005 C CZ    . TYR A 1 126 ? -0.739  10.347  15.180  1.000 50.944  0  126 TYR A CZ    1 ? 
ATOM   1006 O OH    . TYR A 1 126 ? -0.006  10.785  16.245  1.000 47.600  0  126 TYR A OH    1 ? 
ATOM   1007 N N     . HIS A 1 127 ? -3.528  5.922   12.662  1.000 39.276  0  127 HIS A N     1 ? 
ATOM   1008 C CA    . HIS A 1 127 ? -3.040  4.799   13.490  1.000 39.203  0  127 HIS A CA    1 ? 
ATOM   1009 C C     . HIS A 1 127 ? -1.592  4.475   13.097  1.000 39.137  0  127 HIS A C     1 ? 
ATOM   1010 O O     . HIS A 1 127 ? -1.126  4.909   12.004  1.000 30.453  0  127 HIS A O     1 ? 
ATOM   1011 C CB    . HIS A 1 127 ? -4.003  3.613   13.397  1.000 47.380  0  127 HIS A CB    1 ? 
ATOM   1012 C CG    . HIS A 1 127 ? -4.403  3.231   12.016  1.000 50.925  0  127 HIS A CG    1 ? 
ATOM   1013 N ND1   . HIS A 1 127 ? -5.657  3.504   11.514  1.000 57.621  0  127 HIS A ND1   1 ? 
ATOM   1014 C CD2   . HIS A 1 127 ? -3.742  2.560   11.049  1.000 54.589  0  127 HIS A CD2   1 ? 
ATOM   1015 C CE1   . HIS A 1 127 ? -5.746  3.034   10.284  1.000 55.820  0  127 HIS A CE1   1 ? 
ATOM   1016 N NE2   . HIS A 1 127 ? -4.580  2.458   9.974   1.000 54.978  0  127 HIS A NE2   1 ? 
ATOM   1017 N N     . VAL A 1 128 ? -0.875  3.820   14.002  1.000 32.436  0  128 VAL A N     1 ? 
ATOM   1018 C CA    . VAL A 1 128 ? 0.523   3.378   13.782  1.000 34.350  0  128 VAL A CA    1 ? 
ATOM   1019 C C     . VAL A 1 128 ? 0.540   1.870   13.903  1.000 34.318  0  128 VAL A C     1 ? 
ATOM   1020 O O     . VAL A 1 128 ? 0.041   1.353   14.926  1.000 29.488  0  128 VAL A O     1 ? 
ATOM   1021 C CB    . VAL A 1 128 ? 1.500   4.040   14.756  1.000 34.506  0  128 VAL A CB    1 ? 
ATOM   1022 C CG1   . VAL A 1 128 ? 2.945   3.748   14.380  1.000 37.729  0  128 VAL A CG1   1 ? 
ATOM   1023 C CG2   . VAL A 1 128 ? 1.239   5.528   14.847  1.000 35.125  0  128 VAL A CG2   1 ? 
ATOM   1024 N N     . ASP A 1 129 ? 1.037   1.210   12.859  1.000 29.950  0  129 ASP A N     1 ? 
ATOM   1025 C CA    . ASP A 1 129 ? 1.153   -0.259  12.779  1.000 28.624  0  129 ASP A CA    1 ? 
ATOM   1026 C C     . ASP A 1 129 ? 2.609   -0.616  13.036  1.000 30.342  0  129 ASP A C     1 ? 
ATOM   1027 O O     . ASP A 1 129 ? 3.488   -0.161  12.235  1.000 23.577  0  129 ASP A O     1 ? 
ATOM   1028 C CB    . ASP A 1 129 ? 0.699   -0.780  11.419  1.000 30.324  0  129 ASP A CB    1 ? 
ATOM   1029 C CG    . ASP A 1 129 ? -0.726  -0.411  11.094  1.000 34.280  0  129 ASP A CG    1 ? 
ATOM   1030 O OD1   . ASP A 1 129 ? -1.512  -0.230  12.058  1.000 36.970  0  129 ASP A OD1   1 ? 
ATOM   1031 O OD2   . ASP A 1 129 ? -1.040  -0.308  9.890   1.000 40.682  0  129 ASP A OD2   1 ? 
ATOM   1032 N N     . LEU A 1 130 ? 2.863   -1.320  14.140  1.000 28.197  0  130 LEU A N     1 ? 
ATOM   1033 C CA    . LEU A 1 130 ? 4.227   -1.727  14.536  1.000 30.240  0  130 LEU A CA    1 ? 
ATOM   1034 C C     . LEU A 1 130 ? 4.375   -3.184  14.189  1.000 28.072  0  130 LEU A C     1 ? 
ATOM   1035 O O     . LEU A 1 130 ? 3.734   -4.017  14.851  1.000 27.016  0  130 LEU A O     1 ? 
ATOM   1036 C CB    . LEU A 1 130 ? 4.457   -1.491  16.022  1.000 34.384  0  130 LEU A CB    1 ? 
ATOM   1037 C CG    . LEU A 1 130 ? 4.381   -0.036  16.462  1.000 37.205  0  130 LEU A CG    1 ? 
ATOM   1038 C CD1   . LEU A 1 130 ? 3.167   0.173   17.357  1.000 40.325  0  130 LEU A CD1   1 ? 
ATOM   1039 C CD2   . LEU A 1 130 ? 5.661   0.385   17.167  1.000 36.577  0  130 LEU A CD2   1 ? 
ATOM   1040 N N     . ALA A 1 131 ? 5.072   -3.456  13.096  1.000 24.021  0  131 ALA A N     1 ? 
ATOM   1041 C CA    . ALA A 1 131 ? 5.541   -4.805  12.767  1.000 23.324  0  131 ALA A CA    1 ? 
ATOM   1042 C C     . ALA A 1 131 ? 6.642   -5.148  13.773  1.000 20.904  0  131 ALA A C     1 ? 
ATOM   1043 O O     . ALA A 1 131 ? 7.556   -4.295  14.027  1.000 21.613  0  131 ALA A O     1 ? 
ATOM   1044 C CB    . ALA A 1 131 ? 6.016   -4.868  11.332  1.000 22.279  0  131 ALA A CB    1 ? 
ATOM   1045 N N     . VAL A 1 132 ? 6.534   -6.328  14.353  1.000 22.799  0  132 VAL A N     1 ? 
ATOM   1046 C CA    . VAL A 1 132 ? 7.404   -6.767  15.475  1.000 21.367  0  132 VAL A CA    1 ? 
ATOM   1047 C C     . VAL A 1 132 ? 8.254   -7.942  14.997  1.000 19.521  0  132 VAL A C     1 ? 
ATOM   1048 O O     . VAL A 1 132 ? 7.695   -8.906  14.535  1.000 21.252  0  132 VAL A O     1 ? 
ATOM   1049 C CB    . VAL A 1 132 ? 6.535   -7.107  16.698  1.000 22.770  0  132 VAL A CB    1 ? 
ATOM   1050 C CG1   . VAL A 1 132 ? 7.333   -7.777  17.797  1.000 23.937  0  132 VAL A CG1   1 ? 
ATOM   1051 C CG2   . VAL A 1 132 ? 5.846   -5.849  17.206  1.000 25.167  0  132 VAL A CG2   1 ? 
ATOM   1052 N N     . TYR A 1 133 ? 9.578   -7.790  15.050  1.000 19.311  0  133 TYR A N     1 ? 
ATOM   1053 C CA    . TYR A 1 133 ? 10.549  -8.759  14.508  1.000 18.884  0  133 TYR A CA    1 ? 
ATOM   1054 C C     . TYR A 1 133 ? 11.503  -9.227  15.609  1.000 20.718  0  133 TYR A C     1 ? 
ATOM   1055 O O     . TYR A 1 133 ? 11.842  -8.425  16.496  1.000 21.272  0  133 TYR A O     1 ? 
ATOM   1056 C CB    . TYR A 1 133 ? 11.359  -8.113  13.386  1.000 19.159  0  133 TYR A CB    1 ? 
ATOM   1057 C CG    . TYR A 1 133 ? 10.517  -7.579  12.252  1.000 17.002  0  133 TYR A CG    1 ? 
ATOM   1058 C CD1   . TYR A 1 133 ? 10.058  -6.276  12.269  1.000 17.545  0  133 TYR A CD1   1 ? 
ATOM   1059 C CD2   . TYR A 1 133 ? 10.187  -8.373  11.170  1.000 18.392  0  133 TYR A CD2   1 ? 
ATOM   1060 C CE1   . TYR A 1 133 ? 9.298   -5.763  11.232  1.000 17.629  0  133 TYR A CE1   1 ? 
ATOM   1061 C CE2   . TYR A 1 133 ? 9.423   -7.883  10.124  1.000 16.615  0  133 TYR A CE2   1 ? 
ATOM   1062 C CZ    . TYR A 1 133 ? 8.973   -6.574  10.158  1.000 17.960  0  133 TYR A CZ    1 ? 
ATOM   1063 O OH    . TYR A 1 133 ? 8.205   -6.081  9.127   1.000 17.888  0  133 TYR A OH    1 ? 
ATOM   1064 N N     . ALA A 1 134 ? 12.022  -10.438 15.469  1.000 21.432  0  134 ALA A N     1 ? 
ATOM   1065 C CA    . ALA A 1 134 ? 13.136  -10.955 16.306  1.000 21.995  0  134 ALA A CA    1 ? 
ATOM   1066 C C     . ALA A 1 134 ? 14.462  -10.567 15.645  1.000 25.443  0  134 ALA A C     1 ? 
ATOM   1067 O O     . ALA A 1 134 ? 14.466  -10.291 14.432  1.000 23.693  0  134 ALA A O     1 ? 
ATOM   1068 C CB    . ALA A 1 134 ? 13.000  -12.441 16.445  1.000 20.345  0  134 ALA A CB    1 ? 
ATOM   1069 N N     . ASP A 1 135 ? 15.552  -10.556 16.400  1.000 24.231  0  135 ASP A N     1 ? 
ATOM   1070 C CA    . ASP A 1 135 ? 16.895  -10.229 15.866  1.000 23.674  0  135 ASP A CA    1 ? 
ATOM   1071 C C     . ASP A 1 135 ? 17.378  -11.343 14.951  1.000 24.376  0  135 ASP A C     1 ? 
ATOM   1072 O O     . ASP A 1 135 ? 17.517  -12.484 15.378  1.000 27.729  0  135 ASP A O     1 ? 
ATOM   1073 C CB    . ASP A 1 135 ? 17.870  -9.991  17.005  1.000 27.249  0  135 ASP A CB    1 ? 
ATOM   1074 C CG    . ASP A 1 135 ? 19.194  -9.405  16.568  1.000 27.907  0  135 ASP A CG    1 ? 
ATOM   1075 O OD1   . ASP A 1 135 ? 19.640  -9.696  15.438  1.000 33.053  0  135 ASP A OD1   1 ? 
ATOM   1076 O OD2   . ASP A 1 135 ? 19.785  -8.691  17.385  1.000 43.610  0  135 ASP A OD2   1 ? 
ATOM   1077 N N     . PRO A 1 136 ? 17.688  -11.062 13.666  1.000 23.450  0  136 PRO A N     1 ? 
ATOM   1078 C CA    . PRO A 1 136 ? 18.266  -12.076 12.800  1.000 23.608  0  136 PRO A CA    1 ? 
ATOM   1079 C C     . PRO A 1 136 ? 19.544  -12.692 13.411  1.000 26.559  0  136 PRO A C     1 ? 
ATOM   1080 O O     . PRO A 1 136 ? 19.727  -13.860 13.266  1.000 25.859  0  136 PRO A O     1 ? 
ATOM   1081 C CB    . PRO A 1 136 ? 18.583  -11.315 11.502  1.000 23.708  0  136 PRO A CB    1 ? 
ATOM   1082 C CG    . PRO A 1 136 ? 17.623  -10.138 11.504  1.000 22.429  0  136 PRO A CG    1 ? 
ATOM   1083 C CD    . PRO A 1 136 ? 17.444  -9.788  12.970  1.000 23.898  0  136 PRO A CD    1 ? 
ATOM   1084 N N     . GLU A 1 137 ? 20.348  -11.894 14.114  1.000 28.616  0  137 GLU A N     1 ? 
ATOM   1085 C CA    . GLU A 1 137 ? 21.674  -12.322 14.654  1.000 35.020  0  137 GLU A CA    1 ? 
ATOM   1086 C C     . GLU A 1 137 ? 21.462  -13.390 15.733  1.000 33.212  0  137 GLU A C     1 ? 
ATOM   1087 O O     . GLU A 1 137 ? 22.413  -14.101 16.045  1.000 39.741  0  137 GLU A O     1 ? 
ATOM   1088 C CB    . GLU A 1 137 ? 22.447  -11.124 15.210  1.000 37.782  0  137 GLU A CB    1 ? 
ATOM   1089 C CG    . GLU A 1 137 ? 23.114  -10.294 14.126  1.000 44.953  0  137 GLU A CG    1 ? 
ATOM   1090 C CD    . GLU A 1 137 ? 24.113  -11.084 13.294  1.000 49.689  0  137 GLU A CD    1 ? 
ATOM   1091 O OE1   . GLU A 1 137 ? 25.170  -11.483 13.854  1.000 54.989  0  137 GLU A OE1   1 ? 
ATOM   1092 O OE2   . GLU A 1 137 ? 23.819  -11.340 12.104  1.000 55.139  0  137 GLU A OE2   1 ? 
ATOM   1093 N N     . LEU A 1 138 ? 20.249  -13.464 16.281  1.000 31.112  0  138 LEU A N     1 ? 
ATOM   1094 C CA    . LEU A 1 138 ? 19.876  -14.291 17.450  1.000 29.993  0  138 LEU A CA    1 ? 
ATOM   1095 C C     . LEU A 1 138 ? 18.914  -15.375 17.011  1.000 29.847  0  138 LEU A C     1 ? 
ATOM   1096 O O     . LEU A 1 138 ? 18.591  -16.196 17.846  1.000 30.670  0  138 LEU A O     1 ? 
ATOM   1097 C CB    . LEU A 1 138 ? 19.205  -13.397 18.489  1.000 32.322  0  138 LEU A CB    1 ? 
ATOM   1098 C CG    . LEU A 1 138 ? 20.108  -12.802 19.554  1.000 35.711  0  138 LEU A CG    1 ? 
ATOM   1099 C CD1   . LEU A 1 138 ? 21.482  -12.459 19.014  1.000 41.384  0  138 LEU A CD1   1 ? 
ATOM   1100 C CD2   . LEU A 1 138 ? 19.460  -11.588 20.181  1.000 35.364  0  138 LEU A CD2   1 ? 
ATOM   1101 N N     . SER A 1 139 ? 18.456  -15.346 15.754  1.000 26.817  0  139 SER A N     1 ? 
ATOM   1102 C CA    . SER A 1 139 ? 17.345  -16.195 15.260  1.000 27.530  0  139 SER A CA    1 ? 
ATOM   1103 C C     . SER A 1 139 ? 17.768  -16.966 14.008  1.000 30.494  0  139 SER A C     1 ? 
ATOM   1104 O O     . SER A 1 139 ? 16.900  -17.313 13.210  1.000 34.661  0  139 SER A O     1 ? 
ATOM   1105 C CB    . SER A 1 139 ? 16.128  -15.361 15.020  1.000 25.188  0  139 SER A CB    1 ? 
ATOM   1106 O OG    . SER A 1 139 ? 15.836  -14.574 16.161  1.000 23.511  0  139 SER A OG    1 ? 
ATOM   1107 N N     . GLY A 1 140 ? 19.050  -17.286 13.879  1.000 32.141  0  140 GLY A N     1 ? 
ATOM   1108 C CA    . GLY A 1 140 ? 19.546  -18.147 12.789  1.000 33.144  0  140 GLY A CA    1 ? 
ATOM   1109 C C     . GLY A 1 140 ? 19.642  -17.398 11.467  1.000 34.773  0  140 GLY A C     1 ? 
ATOM   1110 O O     . GLY A 1 140 ? 19.593  -18.061 10.413  1.000 32.282  0  140 GLY A O     1 ? 
ATOM   1111 N N     . GLY A 1 141 ? 19.789  -16.069 11.516  1.000 33.366  0  141 GLY A N     1 ? 
ATOM   1112 C CA    . GLY A 1 141 ? 20.111  -15.234 10.340  1.000 32.466  0  141 GLY A CA    1 ? 
ATOM   1113 C C     . GLY A 1 141 ? 18.875  -14.783 9.563   1.000 33.440  0  141 GLY A C     1 ? 
ATOM   1114 O O     . GLY A 1 141 ? 19.049  -14.068 8.574   1.000 29.584  0  141 GLY A O     1 ? 
ATOM   1115 N N     . THR A 1 142 ? 17.662  -15.181 9.962   1.000 31.656  0  142 THR A N     1 ? 
ATOM   1116 C CA    . THR A 1 142 ? 16.415  -14.791 9.238   1.000 33.328  0  142 THR A CA    1 ? 
ATOM   1117 C C     . THR A 1 142 ? 15.723  -13.650 10.005  1.000 27.142  0  142 THR A C     1 ? 
ATOM   1118 O O     . THR A 1 142 ? 15.749  -13.652 11.254  1.000 26.061  0  142 THR A O     1 ? 
ATOM   1119 C CB    . THR A 1 142 ? 15.510  -16.005 8.983   1.000 37.559  0  142 THR A CB    1 ? 
ATOM   1120 O OG1   . THR A 1 142 ? 14.775  -16.271 10.176  1.000 46.814  0  142 THR A OG1   1 ? 
ATOM   1121 C CG2   . THR A 1 142 ? 16.279  -17.248 8.572   1.000 42.640  0  142 THR A CG2   1 ? 
ATOM   1122 N N     . LEU A 1 143 ? 15.091  -12.732 9.288   1.000 23.277  0  143 LEU A N     1 ? 
ATOM   1123 C CA    . LEU A 1 143 ? 14.193  -11.722 9.877   1.000 20.441  0  143 LEU A CA    1 ? 
ATOM   1124 C C     . LEU A 1 143 ? 12.767  -12.272 9.910   1.000 21.609  0  143 LEU A C     1 ? 
ATOM   1125 O O     . LEU A 1 143 ? 12.170  -12.443 8.850   1.000 22.006  0  143 LEU A O     1 ? 
ATOM   1126 C CB    . LEU A 1 143 ? 14.268  -10.441 9.055   1.000 20.804  0  143 LEU A CB    1 ? 
ATOM   1127 C CG    . LEU A 1 143 ? 13.502  -9.255  9.625   1.000 20.228  0  143 LEU A CG    1 ? 
ATOM   1128 C CD1   . LEU A 1 143 ? 14.157  -8.725  10.866  1.000 19.790  0  143 LEU A CD1   1 ? 
ATOM   1129 C CD2   . LEU A 1 143 ? 13.362  -8.146  8.575   1.000 22.350  0  143 LEU A CD2   1 ? 
ATOM   1130 N N     . CYS A 1 144 ? 12.220  -12.481 11.096  1.000 19.604  0  144 CYS A N     1 ? 
ATOM   1131 C CA    . CYS A 1 144 ? 10.876  -13.072 11.258  1.000 21.126  0  144 CYS A CA    1 ? 
ATOM   1132 C C     . CYS A 1 144 ? 9.988   -12.088 11.999  1.000 19.728  0  144 CYS A C     1 ? 
ATOM   1133 O O     . CYS A 1 144 ? 10.404  -11.546 13.066  1.000 19.424  0  144 CYS A O     1 ? 
ATOM   1134 C CB    . CYS A 1 144 ? 10.923  -14.418 11.972  1.000 21.332  0  144 CYS A CB    1 ? 
ATOM   1135 S SG    . CYS A 1 144 ? 11.809  -15.674 11.024  1.000 26.393  0  144 CYS A SG    1 ? 
ATOM   1136 N N     . ILE A 1 145 ? 8.780   -11.952 11.475  1.000 20.950  0  145 ILE A N     1 ? 
ATOM   1137 C CA    . ILE A 1 145 ? 7.704   -11.086 11.996  1.000 20.356  0  145 ILE A CA    1 ? 
ATOM   1138 C C     . ILE A 1 145 ? 6.817   -11.950 12.920  1.000 20.651  0  145 ILE A C     1 ? 
ATOM   1139 O O     . ILE A 1 145 ? 6.628   -13.133 12.624  1.000 22.055  0  145 ILE A O     1 ? 
ATOM   1140 C CB    . ILE A 1 145 ? 6.922   -10.423 10.838  1.000 19.821  0  145 ILE A CB    1 ? 
ATOM   1141 C CG1   . ILE A 1 145 ? 5.994   -9.317  11.352  1.000 21.410  0  145 ILE A CG1   1 ? 
ATOM   1142 C CG2   . ILE A 1 145 ? 6.193   -11.443 9.989   1.000 20.238  0  145 ILE A CG2   1 ? 
ATOM   1143 C CD1   . ILE A 1 145 ? 5.367   -8.463  10.263  1.000 23.778  0  145 ILE A CD1   1 ? 
ATOM   1144 N N     . ALA A 1 146 ? 6.272   -11.338 13.951  1.000 21.519  0  146 ALA A N     1 ? 
ATOM   1145 C CA    . ALA A 1 146 ? 5.374   -11.965 14.951  1.000 25.241  0  146 ALA A CA    1 ? 
ATOM   1146 C C     . ALA A 1 146 ? 3.934   -12.049 14.408  1.000 25.764  0  146 ALA A C     1 ? 
ATOM   1147 O O     . ALA A 1 146 ? 3.297   -11.029 14.356  1.000 25.604  0  146 ALA A O     1 ? 
ATOM   1148 C CB    . ALA A 1 146 ? 5.471   -11.154 16.223  1.000 26.436  0  146 ALA A CB    1 ? 
ATOM   1149 N N     . LYS A 1 147 ? 3.490   -13.232 13.957  1.000 28.776  0  147 LYS A N     1 ? 
ATOM   1150 C CA    . LYS A 1 147 ? 2.171   -13.470 13.311  1.000 31.999  0  147 LYS A CA    1 ? 
ATOM   1151 C C     . LYS A 1 147 ? 1.243   -14.254 14.250  1.000 35.949  0  147 LYS A C     1 ? 
ATOM   1152 O O     . LYS A 1 147 ? 1.744   -15.196 14.912  1.000 29.359  0  147 LYS A O     1 ? 
ATOM   1153 C CB    . LYS A 1 147 ? 2.312   -14.290 12.024  1.000 35.379  0  147 LYS A CB    1 ? 
ATOM   1154 C CG    . LYS A 1 147 ? 2.893   -13.539 10.840  1.000 37.630  0  147 LYS A CG    1 ? 
ATOM   1155 C CD    . LYS A 1 147 ? 1.927   -12.558 10.218  1.000 43.305  0  147 LYS A CD    1 ? 
ATOM   1156 C CE    . LYS A 1 147 ? 1.321   -13.063 8.923   1.000 48.811  0  147 LYS A CE    1 ? 
ATOM   1157 N NZ    . LYS A 1 147 ? 0.621   -14.356 9.114   1.000 54.979  0  147 LYS A NZ    1 ? 
ATOM   1158 N N     . GLY A 1 148 ? -0.059  -13.919 14.225  1.000 39.040  0  148 GLY A N     1 ? 
ATOM   1159 C CA    . GLY A 1 148 ? -1.144  -14.584 14.983  1.000 40.582  0  148 GLY A CA    1 ? 
ATOM   1160 C C     . GLY A 1 148 ? -1.696  -13.698 16.104  1.000 40.599  0  148 GLY A C     1 ? 
ATOM   1161 O O     . GLY A 1 148 ? -0.962  -12.795 16.567  1.000 29.053  0  148 GLY A O     1 ? 
ATOM   1162 N N     . LYS A 1 149 ? -2.929  -13.995 16.549  1.000 43.709  0  149 LYS A N     1 ? 
ATOM   1163 C CA    . LYS A 1 149 ? -3.664  -13.301 17.639  1.000 46.354  0  149 LYS A CA    1 ? 
ATOM   1164 C C     . LYS A 1 149 ? -3.831  -14.255 18.829  1.000 44.963  0  149 LYS A C     1 ? 
ATOM   1165 O O     . LYS A 1 149 ? -3.642  -15.471 18.631  1.000 35.299  0  149 LYS A O     1 ? 
ATOM   1166 C CB    . LYS A 1 149 ? -5.055  -12.860 17.168  1.000 51.549  0  149 LYS A CB    1 ? 
ATOM   1167 C CG    . LYS A 1 149 ? -5.147  -12.250 15.772  1.000 55.014  0  149 LYS A CG    1 ? 
ATOM   1168 C CD    . LYS A 1 149 ? -6.584  -11.914 15.370  1.000 59.589  0  149 LYS A CD    1 ? 
ATOM   1169 C CE    . LYS A 1 149 ? -6.725  -11.379 13.960  1.000 62.974  0  149 LYS A CE    1 ? 
ATOM   1170 N NZ    . LYS A 1 149 ? -6.609  -12.448 12.938  1.000 68.005  0  149 LYS A NZ    1 ? 
ATOM   1171 N N     . GLU A 1 150 ? -4.181  -13.716 20.011  1.000 50.917  0  150 GLU A N     1 ? 
ATOM   1172 C CA    . GLU A 1 150 ? -4.652  -14.511 21.181  1.000 55.940  0  150 GLU A CA    1 ? 
ATOM   1173 C C     . GLU A 1 150 ? -5.596  -15.597 20.661  1.000 58.243  0  150 GLU A C     1 ? 
ATOM   1174 O O     . GLU A 1 150 ? -5.262  -16.785 20.779  1.000 59.943  0  150 GLU A O     1 ? 
ATOM   1175 C CB    . GLU A 1 150 ? -5.353  -13.624 22.214  1.000 58.641  0  150 GLU A CB    1 ? 
ATOM   1176 C CG    . GLU A 1 150 ? -4.402  -12.827 23.102  1.000 61.127  0  150 GLU A CG    1 ? 
ATOM   1177 C CD    . GLU A 1 150 ? -4.274  -11.352 22.754  1.000 64.688  0  150 GLU A CD    1 ? 
ATOM   1178 O OE1   . GLU A 1 150 ? -4.181  -10.528 23.694  1.000 63.286  0  150 GLU A OE1   1 ? 
ATOM   1179 O OE2   . GLU A 1 150 ? -4.257  -11.030 21.545  1.000 68.879  0  150 GLU A OE2   1 ? 
ATOM   1180 N N     . ASN A 1 151 ? -6.690  -15.183 20.032  1.000 67.355  0  151 ASN A N     1 ? 
ATOM   1181 C CA    . ASN A 1 151 ? -7.669  -16.082 19.370  1.000 77.378  0  151 ASN A CA    1 ? 
ATOM   1182 C C     . ASN A 1 151 ? -7.014  -16.683 18.114  1.000 81.990  0  151 ASN A C     1 ? 
ATOM   1183 O O     . ASN A 1 151 ? -7.289  -16.185 17.001  1.000 92.690  0  151 ASN A O     1 ? 
ATOM   1184 C CB    . ASN A 1 151 ? -8.972  -15.333 19.072  1.000 83.182  0  151 ASN A CB    1 ? 
ATOM   1185 C CG    . ASN A 1 151 ? -10.169 -16.251 18.945  1.000 93.290  0  151 ASN A CG    1 ? 
ATOM   1186 O OD1   . ASN A 1 151 ? -10.021 -17.470 18.899  1.000 99.833  0  151 ASN A OD1   1 ? 
ATOM   1187 N ND2   . ASN A 1 151 ? -11.361 -15.678 18.892  1.000 94.925  0  151 ASN A ND2   1 ? 
ATOM   1188 N N     . SER A 1 152 ? -6.167  -17.704 18.303  1.000 78.759  0  152 SER A N     1 ? 
ATOM   1189 C CA    . SER A 1 152 ? -5.387  -18.419 17.253  1.000 78.310  0  152 SER A CA    1 ? 
ATOM   1190 C C     . SER A 1 152 ? -4.355  -19.326 17.941  1.000 76.899  0  152 SER A C     1 ? 
ATOM   1191 O O     . SER A 1 152 ? -4.076  -20.410 17.394  1.000 79.604  0  152 SER A O     1 ? 
ATOM   1192 C CB    . SER A 1 152 ? -4.722  -17.443 16.288  1.000 82.764  0  152 SER A CB    1 ? 
ATOM   1193 O OG    . SER A 1 152 ? -3.907  -18.118 15.336  1.000 79.556  0  152 SER A OG    1 ? 
ATOM   1194 N N     . ARG A 1 157 ? -0.027  -19.011 15.015  1.000 60.090  0  157 ARG A N     1 ? 
ATOM   1195 C CA    . ARG A 1 157 ? 0.692   -17.990 15.829  1.000 58.820  0  157 ARG A CA    1 ? 
ATOM   1196 C C     . ARG A 1 157 ? 2.202   -18.255 15.776  1.000 52.849  0  157 ARG A C     1 ? 
ATOM   1197 O O     . ARG A 1 157 ? 2.729   -18.829 16.747  1.000 51.269  0  157 ARG A O     1 ? 
ATOM   1198 C CB    . ARG A 1 157 ? 0.189   -18.000 17.275  1.000 61.129  0  157 ARG A CB    1 ? 
ATOM   1199 C CG    . ARG A 1 157 ? -0.081  -19.391 17.832  1.000 68.429  0  157 ARG A CG    1 ? 
ATOM   1200 C CD    . ARG A 1 157 ? -0.144  -19.388 19.346  1.000 65.974  0  157 ARG A CD    1 ? 
ATOM   1201 N NE    . ARG A 1 157 ? -1.157  -18.460 19.818  1.000 63.343  0  157 ARG A NE    1 ? 
ATOM   1202 C CZ    . ARG A 1 157 ? -1.130  -17.830 20.985  1.000 62.319  0  157 ARG A CZ    1 ? 
ATOM   1203 N NH1   . ARG A 1 157 ? -0.127  -18.017 21.828  1.000 59.452  0  157 ARG A NH1   1 ? 
ATOM   1204 N NH2   . ARG A 1 157 ? -2.115  -17.008 21.303  1.000 62.186  0  157 ARG A NH2   1 ? 
ATOM   1205 N N     . LEU A 1 158 ? 2.868   -17.787 14.713  1.000 42.007  0  158 LEU A N     1 ? 
ATOM   1206 C CA    . LEU A 1 158 ? 4.240   -18.190 14.339  1.000 39.280  0  158 LEU A CA    1 ? 
ATOM   1207 C C     . LEU A 1 158 ? 5.154   -16.960 14.159  1.000 36.946  0  158 LEU A C     1 ? 
ATOM   1208 O O     . LEU A 1 158 ? 4.676   -15.788 14.191  1.000 32.262  0  158 LEU A O     1 ? 
ATOM   1209 C CB    . LEU A 1 158 ? 4.190   -19.046 13.065  1.000 42.598  0  158 LEU A CB    1 ? 
ATOM   1210 C CG    . LEU A 1 158 ? 3.731   -18.339 11.784  1.000 45.381  0  158 LEU A CG    1 ? 
ATOM   1211 C CD1   . LEU A 1 158 ? 4.451   -18.901 10.560  1.000 50.641  0  158 LEU A CD1   1 ? 
ATOM   1212 C CD2   . LEU A 1 158 ? 2.226   -18.452 11.600  1.000 44.486  0  158 LEU A CD2   1 ? 
ATOM   1213 N N     . TRP A 1 159 ? 6.448   -17.236 14.093  1.000 30.364  0  159 TRP A N     1 ? 
ATOM   1214 C CA    . TRP A 1 159 ? 7.490   -16.334 13.557  1.000 27.912  0  159 TRP A CA    1 ? 
ATOM   1215 C C     . TRP A 1 159 ? 7.610   -16.582 12.045  1.000 26.667  0  159 TRP A C     1 ? 
ATOM   1216 O O     . TRP A 1 159 ? 8.119   -17.615 11.653  1.000 30.015  0  159 TRP A O     1 ? 
ATOM   1217 C CB    . TRP A 1 159 ? 8.808   -16.546 14.318  1.000 23.869  0  159 TRP A CB    1 ? 
ATOM   1218 C CG    . TRP A 1 159 ? 8.776   -16.057 15.742  1.000 25.292  0  159 TRP A CG    1 ? 
ATOM   1219 C CD1   . TRP A 1 159 ? 8.692   -16.837 16.867  1.000 25.251  0  159 TRP A CD1   1 ? 
ATOM   1220 C CD2   . TRP A 1 159 ? 8.862   -14.695 16.220  1.000 24.351  0  159 TRP A CD2   1 ? 
ATOM   1221 N NE1   . TRP A 1 159 ? 8.711   -16.064 17.994  1.000 23.499  0  159 TRP A NE1   1 ? 
ATOM   1222 C CE2   . TRP A 1 159 ? 8.821   -14.748 17.633  1.000 25.400  0  159 TRP A CE2   1 ? 
ATOM   1223 C CE3   . TRP A 1 159 ? 9.008   -13.443 15.606  1.000 25.220  0  159 TRP A CE3   1 ? 
ATOM   1224 C CZ2   . TRP A 1 159 ? 8.893   -13.607 18.426  1.000 24.502  0  159 TRP A CZ2   1 ? 
ATOM   1225 C CZ3   . TRP A 1 159 ? 9.055   -12.316 16.389  1.000 25.090  0  159 TRP A CZ3   1 ? 
ATOM   1226 C CH2   . TRP A 1 159 ? 9.002   -12.396 17.780  1.000 27.573  0  159 TRP A CH2   1 ? 
ATOM   1227 N N     . GLN A 1 160 ? 7.089   -15.691 11.204  1.000 25.771  0  160 GLN A N     1 ? 
ATOM   1228 C CA    . GLN A 1 160 ? 7.161   -15.918 9.740   1.000 24.684  0  160 GLN A CA    1 ? 
ATOM   1229 C C     . GLN A 1 160 ? 8.313   -15.140 9.131   1.000 21.506  0  160 GLN A C     1 ? 
ATOM   1230 O O     . GLN A 1 160 ? 8.446   -13.938 9.440   1.000 23.524  0  160 GLN A O     1 ? 
ATOM   1231 C CB    . GLN A 1 160 ? 5.886   -15.501 9.026   1.000 28.374  0  160 GLN A CB    1 ? 
ATOM   1232 C CG    . GLN A 1 160 ? 5.862   -15.998 7.592   1.000 29.314  0  160 GLN A CG    1 ? 
ATOM   1233 C CD    . GLN A 1 160 ? 4.545   -15.694 6.947   1.000 33.961  0  160 GLN A CD    1 ? 
ATOM   1234 O OE1   . GLN A 1 160 ? 4.074   -14.558 6.987   1.000 36.053  0  160 GLN A OE1   1 ? 
ATOM   1235 N NE2   . GLN A 1 160 ? 3.954   -16.712 6.341   1.000 35.618  0  160 GLN A NE2   1 ? 
ATOM   1236 N N     . ILE A 1 161 ? 9.035   -15.791 8.236   1.000 22.488  0  161 ILE A N     1 ? 
ATOM   1237 C CA    . ILE A 1 161 ? 10.086  -15.177 7.385   1.000 23.008  0  161 ILE A CA    1 ? 
ATOM   1238 C C     . ILE A 1 161 ? 9.473   -13.955 6.702   1.000 21.709  0  161 ILE A C     1 ? 
ATOM   1239 O O     . ILE A 1 161 ? 8.367   -14.083 6.129   1.000 19.587  0  161 ILE A O     1 ? 
ATOM   1240 C CB    . ILE A 1 161 ? 10.661  -16.206 6.392   1.000 26.471  0  161 ILE A CB    1 ? 
ATOM   1241 C CG1   . ILE A 1 161 ? 11.814  -15.635 5.571   1.000 31.084  0  161 ILE A CG1   1 ? 
ATOM   1242 C CG2   . ILE A 1 161 ? 9.587   -16.782 5.494   1.000 27.711  0  161 ILE A CG2   1 ? 
ATOM   1243 C CD1   . ILE A 1 161 ? 12.806  -14.837 6.365   1.000 37.603  0  161 ILE A CD1   1 ? 
ATOM   1244 N N     . SER A 1 162 ? 10.135  -12.800 6.841   1.000 21.493  0  162 SER A N     1 ? 
ATOM   1245 C CA    . SER A 1 162 ? 9.662   -11.486 6.330   1.000 20.966  0  162 SER A CA    1 ? 
ATOM   1246 C C     . SER A 1 162 ? 10.817  -10.747 5.634   1.000 20.354  0  162 SER A C     1 ? 
ATOM   1247 O O     . SER A 1 162 ? 11.995  -10.979 6.032   1.000 17.607  0  162 SER A O     1 ? 
ATOM   1248 C CB    . SER A 1 162 ? 9.106   -10.674 7.466   1.000 23.472  0  162 SER A CB    1 ? 
ATOM   1249 O OG    . SER A 1 162 ? 8.360   -9.561  6.967   1.000 32.958  0  162 SER A OG    1 ? 
ATOM   1250 N N     . ASP A 1 163 ? 10.519  -9.833  4.698   1.000 16.391  0  163 ASP A N     1 ? 
ATOM   1251 C CA    . ASP A 1 163 ? 11.588  -9.071  4.011   1.000 15.504  0  163 ASP A CA    1 ? 
ATOM   1252 C C     . ASP A 1 163 ? 11.052  -7.703  3.617   1.000 15.544  0  163 ASP A C     1 ? 
ATOM   1253 O O     . ASP A 1 163 ? 11.053  -7.359  2.443   1.000 15.517  0  163 ASP A O     1 ? 
ATOM   1254 C CB    . ASP A 1 163 ? 12.152  -9.863  2.836   1.000 16.472  0  163 ASP A CB    1 ? 
ATOM   1255 C CG    . ASP A 1 163 ? 13.412  -9.260  2.231   1.000 16.926  0  163 ASP A CG    1 ? 
ATOM   1256 O OD1   . ASP A 1 163 ? 13.936  -8.303  2.832   1.000 15.628  0  163 ASP A OD1   1 ? 
ATOM   1257 O OD2   . ASP A 1 163 ? 13.811  -9.713  1.134   1.000 16.513  0  163 ASP A OD2   1 ? 
ATOM   1258 N N     . PRO A 1 164 ? 10.624  -6.866  4.588   1.000 14.586  0  164 PRO A N     1 ? 
ATOM   1259 C CA    . PRO A 1 164 ? 10.087  -5.557  4.265   1.000 14.237  0  164 PRO A CA    1 ? 
ATOM   1260 C C     . PRO A 1 164 ? 11.095  -4.661  3.537   1.000 14.848  0  164 PRO A C     1 ? 
ATOM   1261 O O     . PRO A 1 164 ? 10.698  -3.951  2.609   1.000 14.763  0  164 PRO A O     1 ? 
ATOM   1262 C CB    . PRO A 1 164 ? 9.726   -4.932  5.609   1.000 14.368  0  164 PRO A CB    1 ? 
ATOM   1263 C CG    . PRO A 1 164 ? 10.593  -5.675  6.617   1.000 14.749  0  164 PRO A CG    1 ? 
ATOM   1264 C CD    . PRO A 1 164 ? 10.786  -7.056  6.035   1.000 15.117  0  164 PRO A CD    1 ? 
ATOM   1265 N N     . GLN A 1 165 ? 12.356  -4.670  3.955   1.000 14.324  0  165 GLN A N     1 ? 
ATOM   1266 C CA    . GLN A 1 165 ? 13.375  -3.775  3.341   1.000 14.341  0  165 GLN A CA    1 ? 
ATOM   1267 C C     . GLN A 1 165 ? 13.688  -4.270  1.916   1.000 12.728  0  165 GLN A C     1 ? 
ATOM   1268 O O     . GLN A 1 165 ? 13.901  -3.438  1.073   1.000 12.944  0  165 GLN A O     1 ? 
ATOM   1269 C CB    . GLN A 1 165 ? 14.575  -3.635  4.273   1.000 16.642  0  165 GLN A CB    1 ? 
ATOM   1270 C CG    . GLN A 1 165 ? 14.206  -2.873  5.547   1.000 18.591  0  165 GLN A CG    1 ? 
ATOM   1271 C CD    . GLN A 1 165 ? 15.397  -2.321  6.294   1.000 22.102  0  165 GLN A CD    1 ? 
ATOM   1272 O OE1   . GLN A 1 165 ? 15.477  -1.129  6.624   1.000 27.404  0  165 GLN A OE1   1 ? 
ATOM   1273 N NE2   . GLN A 1 165 ? 16.335  -3.184  6.560   1.000 23.799  0  165 GLN A NE2   1 ? 
ATOM   1274 N N     . GLY A 1 166 ? 13.629  -5.572  1.654   1.000 11.639  0  166 GLY A N     1 ? 
ATOM   1275 C CA    . GLY A 1 166 ? 13.797  -6.121  0.294   1.000 12.731  0  166 GLY A CA    1 ? 
ATOM   1276 C C     . GLY A 1 166 ? 12.611  -5.704  -0.579  1.000 11.841  0  166 GLY A C     1 ? 
ATOM   1277 O O     . GLY A 1 166 ? 12.798  -5.397  -1.751  1.000 11.832  0  166 GLY A O     1 ? 
ATOM   1278 N N     . PHE A 1 167 ? 11.395  -5.737  -0.028  1.000 11.602  0  167 PHE A N     1 ? 
ATOM   1279 C CA    . PHE A 1 167 ? 10.208  -5.266  -0.785  1.000 12.248  0  167 PHE A CA    1 ? 
ATOM   1280 C C     . PHE A 1 167 ? 10.430  -3.796  -1.130  1.000 11.973  0  167 PHE A C     1 ? 
ATOM   1281 O O     . PHE A 1 167 ? 10.256  -3.384  -2.283  1.000 11.516  0  167 PHE A O     1 ? 
ATOM   1282 C CB    . PHE A 1 167 ? 8.913   -5.544  -0.031  1.000 13.349  0  167 PHE A CB    1 ? 
ATOM   1283 C CG    . PHE A 1 167 ? 7.698   -5.147  -0.825  1.000 13.984  0  167 PHE A CG    1 ? 
ATOM   1284 C CD1   . PHE A 1 167 ? 7.357   -5.832  -1.987  1.000 14.137  0  167 PHE A CD1   1 ? 
ATOM   1285 C CD2   . PHE A 1 167 ? 6.964   -4.034  -0.476  1.000 13.790  0  167 PHE A CD2   1 ? 
ATOM   1286 C CE1   . PHE A 1 167 ? 6.254   -5.458  -2.732  1.000 15.421  0  167 PHE A CE1   1 ? 
ATOM   1287 C CE2   . PHE A 1 167 ? 5.852   -3.665  -1.227  1.000 14.536  0  167 PHE A CE2   1 ? 
ATOM   1288 C CZ    . PHE A 1 167 ? 5.507   -4.361  -2.352  1.000 14.646  0  167 PHE A CZ    1 ? 
ATOM   1289 N N     . GLN A 1 168 ? 10.794  -2.993  -0.139  1.000 12.772  0  168 GLN A N     1 ? 
ATOM   1290 C CA    . GLN A 1 168 ? 10.977  -1.539  -0.317  1.000 13.759  0  168 GLN A CA    1 ? 
ATOM   1291 C C     . GLN A 1 168 ? 12.073  -1.300  -1.368  1.000 12.911  0  168 GLN A C     1 ? 
ATOM   1292 O O     . GLN A 1 168 ? 11.896  -0.410  -2.241  1.000 10.181  0  168 GLN A O     1 ? 
ATOM   1293 C CB    . GLN A 1 168 ? 11.386  -0.854  0.975   1.000 15.296  0  168 GLN A CB    1 ? 
ATOM   1294 C CG    . GLN A 1 168 ? 10.363  -0.935  2.086   1.000 19.052  0  168 GLN A CG    1 ? 
ATOM   1295 C CD    . GLN A 1 168 ? 11.000  -0.425  3.374   1.000 23.634  0  168 GLN A CD    1 ? 
ATOM   1296 O OE1   . GLN A 1 168 ? 10.544  -0.752  4.490   1.000 24.462  0  168 GLN A OE1   1 ? 
ATOM   1297 N NE2   . GLN A 1 168 ? 12.102  0.340   3.213   1.000 20.092  0  168 GLN A NE2   1 ? 
ATOM   1298 N N     . ASP A 1 169 ? 13.155  -2.065  -1.305  1.000 13.213  0  169 ASP A N     1 ? 
ATOM   1299 C CA    . ASP A 1 169 ? 14.244  -1.986  -2.322  1.000 13.530  0  169 ASP A CA    1 ? 
ATOM   1300 C C     . ASP A 1 169 ? 13.690  -2.311  -3.714  1.000 14.328  0  169 ASP A C     1 ? 
ATOM   1301 O O     . ASP A 1 169 ? 14.059  -1.616  -4.709  1.000 14.110  0  169 ASP A O     1 ? 
ATOM   1302 C CB    . ASP A 1 169 ? 15.380  -2.909  -1.918  1.000 15.846  0  169 ASP A CB    1 ? 
ATOM   1303 C CG    . ASP A 1 169 ? 16.648  -2.758  -2.740  1.000 18.304  0  169 ASP A CG    1 ? 
ATOM   1304 O OD1   . ASP A 1 169 ? 17.441  -3.696  -2.705  1.000 23.823  0  169 ASP A OD1   1 ? 
ATOM   1305 O OD2   . ASP A 1 169 ? 16.849  -1.701  -3.373  1.000 18.548  0  169 ASP A OD2   1 ? 
ATOM   1306 N N     . ARG A 1 170 ? 12.843  -3.321  -3.829  1.000 13.772  0  170 ARG A N     1 ? 
ATOM   1307 C CA    . ARG A 1 170 ? 12.310  -3.748  -5.153  1.000 14.486  0  170 ARG A CA    1 ? 
ATOM   1308 C C     . ARG A 1 170 ? 11.501  -2.591  -5.744  1.000 12.941  0  170 ARG A C     1 ? 
ATOM   1309 O O     . ARG A 1 170 ? 11.642  -2.279  -6.947  1.000 12.641  0  170 ARG A O     1 ? 
ATOM   1310 C CB    . ARG A 1 170 ? 11.514  -5.038  -4.992  1.000 14.959  0  170 ARG A CB    1 ? 
ATOM   1311 C CG    . ARG A 1 170 ? 12.378  -6.273  -4.708  1.000 18.878  0  170 ARG A CG    1 ? 
ATOM   1312 C CD    . ARG A 1 170 ? 12.666  -7.127  -5.913  1.000 21.418  0  170 ARG A CD    1 ? 
ATOM   1313 N NE    . ARG A 1 170 ? 13.798  -8.055  -5.791  1.000 24.117  0  170 ARG A NE    1 ? 
ATOM   1314 C CZ    . ARG A 1 170 ? 14.306  -8.760  -6.829  1.000 25.322  0  170 ARG A CZ    1 ? 
ATOM   1315 N NH1   . ARG A 1 170 ? 13.749  -8.675  -8.024  1.000 25.348  0  170 ARG A NH1   1 ? 
ATOM   1316 N NH2   . ARG A 1 170 ? 15.370  -9.541  -6.675  1.000 21.268  0  170 ARG A NH2   1 ? 
ATOM   1317 N N     . ILE A 1 171 ? 10.666  -1.961  -4.929  1.000 11.905  0  171 ILE A N     1 ? 
ATOM   1318 C CA    . ILE A 1 171 ? 9.792   -0.849  -5.385  1.000 13.620  0  171 ILE A CA    1 ? 
ATOM   1319 C C     . ILE A 1 171 ? 10.680  0.345   -5.791  1.000 13.840  0  171 ILE A C     1 ? 
ATOM   1320 O O     . ILE A 1 171 ? 10.427  0.964   -6.841  1.000 13.773  0  171 ILE A O     1 ? 
ATOM   1321 C CB    . ILE A 1 171 ? 8.760   -0.513  -4.293  1.000 12.416  0  171 ILE A CB    1 ? 
ATOM   1322 C CG1   . ILE A 1 171 ? 7.900   -1.733  -3.967  1.000 12.048  0  171 ILE A CG1   1 ? 
ATOM   1323 C CG2   . ILE A 1 171 ? 7.894   0.679   -4.708  1.000 12.734  0  171 ILE A CG2   1 ? 
ATOM   1324 C CD1   . ILE A 1 171 ? 7.210   -2.358  -5.191  1.000 11.312  0  171 ILE A CD1   1 ? 
ATOM   1325 N N     . ALA A 1 172 ? 11.716  0.646   -5.016  1.000 15.107  0  172 ALA A N     1 ? 
ATOM   1326 C CA    . ALA A 1 172 ? 12.635  1.781   -5.305  1.000 14.227  0  172 ALA A CA    1 ? 
ATOM   1327 C C     . ALA A 1 172 ? 13.455  1.535   -6.587  1.000 14.416  0  172 ALA A C     1 ? 
ATOM   1328 O O     . ALA A 1 172 ? 13.860  2.502   -7.239  1.000 15.029  0  172 ALA A O     1 ? 
ATOM   1329 C CB    . ALA A 1 172 ? 13.535  2.011   -4.126  1.000 14.898  0  172 ALA A CB    1 ? 
ATOM   1330 N N     . SER A 1 173 ? 13.793  0.296   -6.861  1.000 14.321  0  173 SER A N     1 ? 
ATOM   1331 C CA    . SER A 1 173 ? 14.878  -0.077  -7.810  1.000 14.347  0  173 SER A CA    1 ? 
ATOM   1332 C C     . SER A 1 173 ? 14.301  -0.451  -9.170  1.000 14.369  0  173 SER A C     1 ? 
ATOM   1333 O O     . SER A 1 173 ? 15.101  -0.615  -10.115 1.000 14.186  0  173 SER A O     1 ? 
ATOM   1334 C CB    . SER A 1 173 ? 15.717  -1.195  -7.257  1.000 14.724  0  173 SER A CB    1 ? 
ATOM   1335 O OG    . SER A 1 173 ? 16.289  -0.811  -6.016  1.000 16.130  0  173 SER A OG    1 ? 
ATOM   1336 N N     . LYS A 1 174 ? 12.975  -0.611  -9.280  1.000 13.080  0  174 LYS A N     1 ? 
ATOM   1337 C CA    . LYS A 1 174 ? 12.374  -1.162  -10.511 1.000 15.210  0  174 LYS A CA    1 ? 
ATOM   1338 C C     . LYS A 1 174 ? 12.685  -0.216  -11.657 1.000 14.476  0  174 LYS A C     1 ? 
ATOM   1339 O O     . LYS A 1 174 ? 13.052  -0.700  -12.761 1.000 13.834  0  174 LYS A O     1 ? 
ATOM   1340 C CB    . LYS A 1 174 ? 10.856  -1.300  -10.389 1.000 15.030  0  174 LYS A CB    1 ? 
ATOM   1341 C CG    . LYS A 1 174 ? 10.205  -1.892  -11.634 1.000 16.993  0  174 LYS A CG    1 ? 
ATOM   1342 C CD    . LYS A 1 174 ? 8.686   -1.807  -11.566 1.000 16.681  0  174 LYS A CD    1 ? 
ATOM   1343 C CE    . LYS A 1 174 ? 7.973   -2.198  -12.857 1.000 15.762  0  174 LYS A CE    1 ? 
ATOM   1344 N NZ    . LYS A 1 174 ? 8.332   -3.564  -13.319 1.000 17.062  0  174 LYS A NZ    1 ? 
ATOM   1345 N N     . LEU A 1 175 ? 12.569  1.096   -11.395 1.000 12.300  0  175 LEU A N     1 ? 
ATOM   1346 C CA    . LEU A 1 175 ? 12.841  2.154   -12.383 1.000 13.362  0  175 LEU A CA    1 ? 
ATOM   1347 C C     . LEU A 1 175 ? 13.677  3.217   -11.690 1.000 12.964  0  175 LEU A C     1 ? 
ATOM   1348 O O     . LEU A 1 175 ? 13.864  3.080   -10.485 1.000 12.419  0  175 LEU A O     1 ? 
ATOM   1349 C CB    . LEU A 1 175 ? 11.514  2.722   -12.917 1.000 13.931  0  175 LEU A CB    1 ? 
ATOM   1350 C CG    . LEU A 1 175 ? 10.658  1.710   -13.683 1.000 14.429  0  175 LEU A CG    1 ? 
ATOM   1351 C CD1   . LEU A 1 175 ? 9.207   2.121   -13.692 1.000 13.754  0  175 LEU A CD1   1 ? 
ATOM   1352 C CD2   . LEU A 1 175 ? 11.157  1.515   -15.098 1.000 15.371  0  175 LEU A CD2   1 ? 
ATOM   1353 N N     . SER A 1 176 ? 14.078  4.248   -12.426 1.000 12.412  0  176 SER A N     1 ? 
ATOM   1354 C CA    . SER A 1 176 ? 14.780  5.427   -11.865 1.000 12.943  0  176 SER A CA    1 ? 
ATOM   1355 C C     . SER A 1 176 ? 14.157  6.724   -12.380 1.000 12.589  0  176 SER A C     1 ? 
ATOM   1356 O O     . SER A 1 176 ? 13.346  6.705   -13.368 1.000 13.497  0  176 SER A O     1 ? 
ATOM   1357 C CB    . SER A 1 176 ? 16.265  5.325   -12.199 1.000 13.346  0  176 SER A CB    1 ? 
ATOM   1358 O OG    . SER A 1 176 ? 16.449  5.460   -13.590 1.000 14.408  0  176 SER A OG    1 ? 
ATOM   1359 N N     . GLY A 1 177 ? 14.498  7.824   -11.727 1.000 13.212  0  177 GLY A N     1 ? 
ATOM   1360 C CA    . GLY A 1 177 ? 14.218  9.197   -12.182 1.000 12.512  0  177 GLY A CA    1 ? 
ATOM   1361 C C     . GLY A 1 177 ? 12.736  9.424   -12.479 1.000 12.923  0  177 GLY A C     1 ? 
ATOM   1362 O O     . GLY A 1 177 ? 11.891  8.974   -11.690 1.000 11.117  0  177 GLY A O     1 ? 
ATOM   1363 N N     . ASP A 1 178 ? 12.437  10.072  -13.605 1.000 13.063  0  178 ASP A N     1 ? 
ATOM   1364 C CA    . ASP A 1 178 ? 11.044  10.423  -14.010 1.000 14.932  0  178 ASP A CA    1 ? 
ATOM   1365 C C     . ASP A 1 178 ? 10.260  9.158   -14.391 1.000 12.727  0  178 ASP A C     1 ? 
ATOM   1366 O O     . ASP A 1 178 ? 9.024   9.165   -14.247 1.000 11.384  0  178 ASP A O     1 ? 
ATOM   1367 C CB    . ASP A 1 178 ? 11.047  11.438  -15.151 1.000 15.972  0  178 ASP A CB    1 ? 
ATOM   1368 C CG    . ASP A 1 178 ? 11.577  12.781  -14.684 1.000 21.150  0  178 ASP A CG    1 ? 
ATOM   1369 O OD1   . ASP A 1 178 ? 11.678  12.942  -13.469 1.000 22.046  0  178 ASP A OD1   1 ? 
ATOM   1370 O OD2   . ASP A 1 178 ? 11.870  13.632  -15.535 1.000 22.176  0  178 ASP A OD2   1 ? 
ATOM   1371 N N     . ASP A 1 179 ? 10.911  8.114   -14.857 1.000 10.839  0  179 ASP A N     1 ? 
ATOM   1372 C CA    . ASP A 1 179 ? 10.197  6.815   -15.062 1.000 12.184  0  179 ASP A CA    1 ? 
ATOM   1373 C C     . ASP A 1 179 ? 9.638   6.289   -13.722 1.000 12.042  0  179 ASP A C     1 ? 
ATOM   1374 O O     . ASP A 1 179 ? 8.423   5.865   -13.634 1.000 12.241  0  179 ASP A O     1 ? 
ATOM   1375 C CB    . ASP A 1 179 ? 11.116  5.749   -15.637 1.000 12.692  0  179 ASP A CB    1 ? 
ATOM   1376 C CG    . ASP A 1 179 ? 11.498  5.918   -17.091 1.000 15.369  0  179 ASP A CG    1 ? 
ATOM   1377 O OD1   . ASP A 1 179 ? 10.942  6.840   -17.787 1.000 15.687  0  179 ASP A OD1   1 ? 
ATOM   1378 O OD2   . ASP A 1 179 ? 12.281  5.038   -17.545 1.000 17.080  0  179 ASP A OD2   1 ? 
ATOM   1379 N N     . ALA A 1 180 ? 10.474  6.238   -12.704 1.000 11.202  0  180 ALA A N     1 ? 
ATOM   1380 C CA    . ALA A 1 180 ? 10.080  5.813   -11.353 1.000 11.795  0  180 ALA A CA    1 ? 
ATOM   1381 C C     . ALA A 1 180 ? 9.014   6.784   -10.804 1.000 11.958  0  180 ALA A C     1 ? 
ATOM   1382 O O     . ALA A 1 180 ? 8.093   6.308   -10.124 1.000 9.928   0  180 ALA A O     1 ? 
ATOM   1383 C CB    . ALA A 1 180 ? 11.268  5.691   -10.422 1.000 12.781  0  180 ALA A CB    1 ? 
ATOM   1384 N N     . ALA A 1 181 ? 9.095   8.075   -11.099 1.000 11.687  0  181 ALA A N     1 ? 
ATOM   1385 C CA    . ALA A 1 181 ? 8.038   9.035   -10.686 1.000 11.048  0  181 ALA A CA    1 ? 
ATOM   1386 C C     . ALA A 1 181 ? 6.683   8.637   -11.296 1.000 11.183  0  181 ALA A C     1 ? 
ATOM   1387 O O     . ALA A 1 181 ? 5.672   8.654   -10.546 1.000 9.367   0  181 ALA A O     1 ? 
ATOM   1388 C CB    . ALA A 1 181 ? 8.426   10.461  -11.010 1.000 12.340  0  181 ALA A CB    1 ? 
ATOM   1389 N N     . GLN A 1 182 ? 6.622   8.258   -12.581 1.000 10.503  0  182 GLN A N     1 ? 
ATOM   1390 C CA    . GLN A 1 182 ? 5.305   7.866   -13.167 1.000 10.832  0  182 GLN A CA    1 ? 
ATOM   1391 C C     . GLN A 1 182 ? 4.762   6.628   -12.459 1.000 10.725  0  182 GLN A C     1 ? 
ATOM   1392 O O     . GLN A 1 182 ? 3.561   6.565   -12.259 1.000 9.711   0  182 GLN A O     1 ? 
ATOM   1393 C CB    . GLN A 1 182 ? 5.404   7.583   -14.653 1.000 10.532  0  182 GLN A CB    1 ? 
ATOM   1394 C CG    . GLN A 1 182 ? 4.053   7.451   -15.313 1.000 10.263  0  182 GLN A CG    1 ? 
ATOM   1395 C CD    . GLN A 1 182 ? 4.200   7.227   -16.804 1.000 9.809   0  182 GLN A CD    1 ? 
ATOM   1396 O OE1   . GLN A 1 182 ? 4.877   6.285   -17.255 1.000 10.349  0  182 GLN A OE1   1 ? 
ATOM   1397 N NE2   . GLN A 1 182 ? 3.456   8.003   -17.572 1.000 9.211   0  182 GLN A NE2   1 ? 
ATOM   1398 N N     . PHE A 1 183 ? 5.618   5.623   -12.255 1.000 10.453  0  183 PHE A N     1 ? 
ATOM   1399 C CA    . PHE A 1 183 ? 5.321   4.384   -11.502 1.000 10.309  0  183 PHE A CA    1 ? 
ATOM   1400 C C     . PHE A 1 183 ? 4.654   4.724   -10.153 1.000 9.714   0  183 PHE A C     1 ? 
ATOM   1401 O O     . PHE A 1 183 ? 3.507   4.229   -9.883  1.000 8.300   0  183 PHE A O     1 ? 
ATOM   1402 C CB    . PHE A 1 183 ? 6.619   3.600   -11.378 1.000 9.611   0  183 PHE A CB    1 ? 
ATOM   1403 C CG    . PHE A 1 183 ? 6.606   2.436   -10.445 1.000 9.846   0  183 PHE A CG    1 ? 
ATOM   1404 C CD1   . PHE A 1 183 ? 5.902   1.268   -10.754 1.000 10.600  0  183 PHE A CD1   1 ? 
ATOM   1405 C CD2   . PHE A 1 183 ? 7.452   2.421   -9.352  1.000 10.794  0  183 PHE A CD2   1 ? 
ATOM   1406 C CE1   . PHE A 1 183 ? 5.986   0.164   -9.938  1.000 10.156  0  183 PHE A CE1   1 ? 
ATOM   1407 C CE2   . PHE A 1 183 ? 7.538   1.309   -8.546  1.000 10.838  0  183 PHE A CE2   1 ? 
ATOM   1408 C CZ    . PHE A 1 183 ? 6.817   0.177   -8.846  1.000 10.926  0  183 PHE A CZ    1 ? 
ATOM   1409 N N     . ARG A 1 184 ? 5.265   5.649   -9.406  1.000 10.032  0  184 ARG A N     1 ? 
ATOM   1410 C CA    . ARG A 1 184 ? 4.758   6.065   -8.076  1.000 10.972  0  184 ARG A CA    1 ? 
ATOM   1411 C C     . ARG A 1 184 ? 3.406   6.783   -8.233  1.000 9.577   0  184 ARG A C     1 ? 
ATOM   1412 O O     . ARG A 1 184 ? 2.466   6.479   -7.441  1.000 9.656   0  184 ARG A O     1 ? 
ATOM   1413 C CB    . ARG A 1 184 ? 5.829   6.862   -7.329  1.000 11.189  0  184 ARG A CB    1 ? 
ATOM   1414 C CG    . ARG A 1 184 ? 6.993   6.001   -6.828  1.000 12.720  0  184 ARG A CG    1 ? 
ATOM   1415 C CD    . ARG A 1 184 ? 7.935   6.681   -5.845  1.000 13.401  0  184 ARG A CD    1 ? 
ATOM   1416 N NE    . ARG A 1 184 ? 8.303   7.999   -6.283  1.000 14.296  0  184 ARG A NE    1 ? 
ATOM   1417 C CZ    . ARG A 1 184 ? 9.378   8.256   -7.026  1.000 17.755  0  184 ARG A CZ    1 ? 
ATOM   1418 N NH1   . ARG A 1 184 ? 10.162  7.267   -7.419  1.000 17.084  0  184 ARG A NH1   1 ? 
ATOM   1419 N NH2   . ARG A 1 184 ? 9.639   9.483   -7.421  1.000 19.207  0  184 ARG A NH2   1 ? 
ATOM   1420 N N     . ARG A 1 185 ? 3.271   7.643   -9.236  1.000 10.345  0  185 ARG A N     1 ? 
ATOM   1421 C CA    . ARG A 1 185 ? 2.006   8.391   -9.458  1.000 10.727  0  185 ARG A CA    1 ? 
ATOM   1422 C C     . ARG A 1 185 ? 0.907   7.365   -9.716  1.000 11.564  0  185 ARG A C     1 ? 
ATOM   1423 O O     . ARG A 1 185 ? -0.201  7.531   -9.189  1.000 10.938  0  185 ARG A O     1 ? 
ATOM   1424 C CB    . ARG A 1 185 ? 2.138   9.370   -10.622 1.000 10.470  0  185 ARG A CB    1 ? 
ATOM   1425 C CG    . ARG A 1 185 ? 3.037   10.572  -10.365 1.000 11.330  0  185 ARG A CG    1 ? 
ATOM   1426 C CD    . ARG A 1 185 ? 2.787   11.729  -11.329 1.000 11.295  0  185 ARG A CD    1 ? 
ATOM   1427 N NE    . ARG A 1 185 ? 3.052   11.373  -12.730 1.000 11.366  0  185 ARG A NE    1 ? 
ATOM   1428 C CZ    . ARG A 1 185 ? 4.263   11.406  -13.304 1.000 11.750  0  185 ARG A CZ    1 ? 
ATOM   1429 N NH1   . ARG A 1 185 ? 5.317   11.751  -12.591 1.000 11.208  0  185 ARG A NH1   1 ? 
ATOM   1430 N NH2   . ARG A 1 185 ? 4.410   11.067  -14.570 1.000 11.209  0  185 ARG A NH2   1 ? 
ATOM   1431 N N     . CYS A 1 186 ? 1.202   6.340   -10.514 1.000 11.173  0  186 CYS A N     1 ? 
ATOM   1432 C CA    . CYS A 1 186 ? 0.170   5.358   -10.925 1.000 11.603  0  186 CYS A CA    1 ? 
ATOM   1433 C C     . CYS A 1 186 ? -0.241  4.485   -9.741  1.000 10.776  0  186 CYS A C     1 ? 
ATOM   1434 O O     . CYS A 1 186 ? -1.464  4.190   -9.621  1.000 10.531  0  186 CYS A O     1 ? 
ATOM   1435 C CB    . CYS A 1 186 ? 0.618   4.568   -12.148 1.000 13.885  0  186 CYS A CB    1 ? 
ATOM   1436 S SG    . CYS A 1 186 ? 0.459   5.580   -13.658 1.000 15.123  0  186 CYS A SG    1 ? 
ATOM   1437 N N     . ILE A 1 187 ? 0.672   4.172   -8.825  1.000 9.307   0  187 ILE A N     1 ? 
ATOM   1438 C CA    . ILE A 1 187 ? 0.263   3.513   -7.553  1.000 9.449   0  187 ILE A CA    1 ? 
ATOM   1439 C C     . ILE A 1 187 ? -0.687  4.445   -6.794  1.000 9.161   0  187 ILE A C     1 ? 
ATOM   1440 O O     . ILE A 1 187 ? -1.742  3.997   -6.317  1.000 9.383   0  187 ILE A O     1 ? 
ATOM   1441 C CB    . ILE A 1 187 ? 1.503   3.090   -6.748  1.000 9.481   0  187 ILE A CB    1 ? 
ATOM   1442 C CG1   . ILE A 1 187 ? 2.250   1.965   -7.476  1.000 10.165  0  187 ILE A CG1   1 ? 
ATOM   1443 C CG2   . ILE A 1 187 ? 1.143   2.735   -5.314  1.000 9.322   0  187 ILE A CG2   1 ? 
ATOM   1444 C CD1   . ILE A 1 187 ? 3.692   1.808   -7.032  1.000 10.558  0  187 ILE A CD1   1 ? 
ATOM   1445 N N     . ARG A 1 188 ? -0.325  5.696   -6.621  1.000 9.544   0  188 ARG A N     1 ? 
ATOM   1446 C CA    . ARG A 1 188 ? -1.176  6.637   -5.869  1.000 9.970   0  188 ARG A CA    1 ? 
ATOM   1447 C C     . ARG A 1 188 ? -2.531  6.759   -6.551  1.000 10.265  0  188 ARG A C     1 ? 
ATOM   1448 O O     . ARG A 1 188 ? -3.532  6.829   -5.825  1.000 9.926   0  188 ARG A O     1 ? 
ATOM   1449 C CB    . ARG A 1 188 ? -0.472  7.983   -5.756  1.000 10.502  0  188 ARG A CB    1 ? 
ATOM   1450 C CG    . ARG A 1 188 ? 0.724   7.959   -4.809  1.000 11.163  0  188 ARG A CG    1 ? 
ATOM   1451 C CD    . ARG A 1 188 ? 1.091   9.414   -4.537  1.000 13.149  0  188 ARG A CD    1 ? 
ATOM   1452 N NE    . ARG A 1 188 ? 2.198   9.572   -3.614  1.000 13.414  0  188 ARG A NE    1 ? 
ATOM   1453 C CZ    . ARG A 1 188 ? 3.451   9.783   -3.972  1.000 15.080  0  188 ARG A CZ    1 ? 
ATOM   1454 N NH1   . ARG A 1 188 ? 3.789   9.812   -5.245  1.000 16.714  0  188 ARG A NH1   1 ? 
ATOM   1455 N NH2   . ARG A 1 188 ? 4.381   9.914   -3.049  1.000 17.451  0  188 ARG A NH2   1 ? 
ATOM   1456 N N     . TYR A 1 189 ? -2.582  6.816   -7.887  1.000 10.371  0  189 TYR A N     1 ? 
ATOM   1457 C CA    . TYR A 1 189 ? -3.885  6.964   -8.589  1.000 10.800  0  189 TYR A CA    1 ? 
ATOM   1458 C C     . TYR A 1 189 ? -4.782  5.809   -8.184  1.000 12.097  0  189 TYR A C     1 ? 
ATOM   1459 O O     . TYR A 1 189 ? -5.978  6.033   -7.856  1.000 10.580  0  189 TYR A O     1 ? 
ATOM   1460 C CB    . TYR A 1 189 ? -3.752  7.040   -10.112 1.000 10.436  0  189 TYR A CB    1 ? 
ATOM   1461 C CG    . TYR A 1 189 ? -2.963  8.211   -10.659 1.000 9.466   0  189 TYR A CG    1 ? 
ATOM   1462 C CD1   . TYR A 1 189 ? -2.934  9.457   -10.052 1.000 9.974   0  189 TYR A CD1   1 ? 
ATOM   1463 C CD2   . TYR A 1 189 ? -2.182  8.030   -11.779 1.000 9.559   0  189 TYR A CD2   1 ? 
ATOM   1464 C CE1   . TYR A 1 189 ? -2.210  10.508  -10.599 1.000 10.207  0  189 TYR A CE1   1 ? 
ATOM   1465 C CE2   . TYR A 1 189 ? -1.463  9.059   -12.347 1.000 9.253   0  189 TYR A CE2   1 ? 
ATOM   1466 C CZ    . TYR A 1 189 ? -1.442  10.305  -11.734 1.000 9.704   0  189 TYR A CZ    1 ? 
ATOM   1467 O OH    . TYR A 1 189 ? -0.676  11.306  -12.294 1.000 10.094  0  189 TYR A OH    1 ? 
ATOM   1468 N N     . LEU A 1 190 ? -4.261  4.575   -8.220  1.000 11.306  0  190 LEU A N     1 ? 
ATOM   1469 C CA    . LEU A 1 190 ? -5.093  3.401   -7.864  1.000 12.388  0  190 LEU A CA    1 ? 
ATOM   1470 C C     . LEU A 1 190 ? -5.433  3.380   -6.375  1.000 11.343  0  190 LEU A C     1 ? 
ATOM   1471 O O     . LEU A 1 190 ? -6.500  2.888   -6.055  1.000 11.153  0  190 LEU A O     1 ? 
ATOM   1472 C CB    . LEU A 1 190 ? -4.386  2.112   -8.274  1.000 13.215  0  190 LEU A CB    1 ? 
ATOM   1473 C CG    . LEU A 1 190 ? -4.338  1.890   -9.771  1.000 15.813  0  190 LEU A CG    1 ? 
ATOM   1474 C CD1   . LEU A 1 190 ? -3.718  0.530   -10.071 1.000 17.879  0  190 LEU A CD1   1 ? 
ATOM   1475 C CD2   . LEU A 1 190 ? -5.730  2.011   -10.369 1.000 18.248  0  190 LEU A CD2   1 ? 
ATOM   1476 N N     . LYS A 1 191 ? -4.589  3.920   -5.499  1.000 10.817  0  191 LYS A N     1 ? 
ATOM   1477 C CA    . LYS A 1 191 ? -4.919  3.998   -4.047  1.000 11.026  0  191 LYS A CA    1 ? 
ATOM   1478 C C     . LYS A 1 191 ? -6.093  4.954   -3.828  1.000 10.683  0  191 LYS A C     1 ? 
ATOM   1479 O O     . LYS A 1 191 ? -7.001  4.592   -3.057  1.000 10.013  0  191 LYS A O     1 ? 
ATOM   1480 C CB    . LYS A 1 191 ? -3.722  4.389   -3.187  1.000 11.665  0  191 LYS A CB    1 ? 
ATOM   1481 C CG    . LYS A 1 191 ? -2.672  3.296   -3.003  1.000 13.709  0  191 LYS A CG    1 ? 
ATOM   1482 C CD    . LYS A 1 191 ? -1.565  3.723   -2.118  1.000 14.768  0  191 LYS A CD    1 ? 
ATOM   1483 C CE    . LYS A 1 191 ? -0.528  2.663   -1.865  1.000 17.243  0  191 LYS A CE    1 ? 
ATOM   1484 N NZ    . LYS A 1 191 ? 0.434   3.178   -0.869  1.000 17.093  0  191 LYS A NZ    1 ? 
ATOM   1485 N N     . ARG A 1 192 ? -6.132  6.078   -4.551  1.000 11.832  0  192 ARG A N     1 ? 
ATOM   1486 C CA    . ARG A 1 192 ? -7.286  7.031   -4.426  1.000 11.393  0  192 ARG A CA    1 ? 
ATOM   1487 C C     . ARG A 1 192 ? -8.544  6.397   -5.017  1.000 10.746  0  192 ARG A C     1 ? 
ATOM   1488 O O     . ARG A 1 192 ? -9.624  6.470   -4.376  1.000 9.954   0  192 ARG A O     1 ? 
ATOM   1489 C CB    . ARG A 1 192 ? -6.973  8.371   -5.088  1.000 11.709  0  192 ARG A CB    1 ? 
ATOM   1490 C CG    . ARG A 1 192 ? -8.100  9.380   -4.978  1.000 12.540  0  192 ARG A CG    1 ? 
ATOM   1491 C CD    . ARG A 1 192 ? -8.769  9.493   -3.617  1.000 12.849  0  192 ARG A CD    1 ? 
ATOM   1492 N NE    . ARG A 1 192 ? -7.942  10.056  -2.588  1.000 13.994  0  192 ARG A NE    1 ? 
ATOM   1493 C CZ    . ARG A 1 192 ? -7.821  11.346  -2.262  1.000 14.102  0  192 ARG A CZ    1 ? 
ATOM   1494 N NH1   . ARG A 1 192 ? -8.519  12.290  -2.880  1.000 13.974  0  192 ARG A NH1   1 ? 
ATOM   1495 N NH2   . ARG A 1 192 ? -7.027  11.662  -1.250  1.000 13.750  0  192 ARG A NH2   1 ? 
ATOM   1496 N N     . TRP A 1 193 ? -8.415  5.730   -6.162  1.000 10.425  0  193 TRP A N     1 ? 
ATOM   1497 C CA    . TRP A 1 193 ? -9.540  4.952   -6.764  1.000 10.538  0  193 TRP A CA    1 ? 
ATOM   1498 C C     . TRP A 1 193 ? -10.066 3.932   -5.750  1.000 11.376  0  193 TRP A C     1 ? 
ATOM   1499 O O     . TRP A 1 193 ? -11.332 3.835   -5.570  1.000 12.555  0  193 TRP A O     1 ? 
ATOM   1500 C CB    . TRP A 1 193 ? -9.087  4.276   -8.054  1.000 10.145  0  193 TRP A CB    1 ? 
ATOM   1501 C CG    . TRP A 1 193 ? -10.020 3.230   -8.580  1.000 9.542   0  193 TRP A CG    1 ? 
ATOM   1502 C CD1   . TRP A 1 193 ? -11.237 3.423   -9.171  1.000 10.069  0  193 TRP A CD1   1 ? 
ATOM   1503 C CD2   . TRP A 1 193 ? -9.827  1.807   -8.536  1.000 10.545  0  193 TRP A CD2   1 ? 
ATOM   1504 N NE1   . TRP A 1 193 ? -11.792 2.208   -9.537  1.000 9.959   0  193 TRP A NE1   1 ? 
ATOM   1505 C CE2   . TRP A 1 193 ? -10.932 1.206   -9.199  1.000 9.238   0  193 TRP A CE2   1 ? 
ATOM   1506 C CE3   . TRP A 1 193 ? -8.801  0.973   -8.061  1.000 10.875  0  193 TRP A CE3   1 ? 
ATOM   1507 C CZ2   . TRP A 1 193 ? -11.052 -0.176  -9.336  1.000 9.727   0  193 TRP A CZ2   1 ? 
ATOM   1508 C CZ3   . TRP A 1 193 ? -8.926  -0.392  -8.207  1.000 9.848   0  193 TRP A CZ3   1 ? 
ATOM   1509 C CH2   . TRP A 1 193 ? -10.032 -0.951  -8.843  1.000 9.807   0  193 TRP A CH2   1 ? 
ATOM   1510 N N     . ARG A 1 194 ? -9.162  3.204   -5.112  1.000 11.714  0  194 ARG A N     1 ? 
ATOM   1511 C CA    . ARG A 1 194 ? -9.484  2.207   -4.063  1.000 13.583  0  194 ARG A CA    1 ? 
ATOM   1512 C C     . ARG A 1 194 ? -10.291 2.906   -2.957  1.000 12.565  0  194 ARG A C     1 ? 
ATOM   1513 O O     . ARG A 1 194 ? -11.357 2.356   -2.540  1.000 11.955  0  194 ARG A O     1 ? 
ATOM   1514 C CB    . ARG A 1 194 ? -8.214  1.555   -3.509  1.000 16.258  0  194 ARG A CB    1 ? 
ATOM   1515 C CG    . ARG A 1 194 ? -8.429  0.733   -2.245  1.000 19.707  0  194 ARG A CG    1 ? 
ATOM   1516 C CD    . ARG A 1 194 ? -7.221  0.692   -1.318  1.000 23.039  0  194 ARG A CD    1 ? 
ATOM   1517 N NE    . ARG A 1 194 ? -6.890  2.028   -0.882  1.000 24.894  0  194 ARG A NE    1 ? 
ATOM   1518 C CZ    . ARG A 1 194 ? -5.695  2.417   -0.422  1.000 24.304  0  194 ARG A CZ    1 ? 
ATOM   1519 N NH1   . ARG A 1 194 ? -4.691  1.563   -0.318  1.000 28.606  0  194 ARG A NH1   1 ? 
ATOM   1520 N NH2   . ARG A 1 194 ? -5.506  3.677   -0.076  1.000 27.322  0  194 ARG A NH2   1 ? 
ATOM   1521 N N     . ASP A 1 195 ? -9.825  4.057   -2.481  1.000 11.962  0  195 ASP A N     1 ? 
ATOM   1522 C CA    . ASP A 1 195 ? -10.458 4.757   -1.327  1.000 13.229  0  195 ASP A CA    1 ? 
ATOM   1523 C C     . ASP A 1 195 ? -11.825 5.300   -1.743  1.000 13.278  0  195 ASP A C     1 ? 
ATOM   1524 O O     . ASP A 1 195 ? -12.802 5.156   -0.912  1.000 12.878  0  195 ASP A O     1 ? 
ATOM   1525 C CB    . ASP A 1 195 ? -9.560  5.850   -0.748  1.000 13.856  0  195 ASP A CB    1 ? 
ATOM   1526 C CG    . ASP A 1 195 ? -8.371  5.329   0.033   1.000 17.072  0  195 ASP A CG    1 ? 
ATOM   1527 O OD1   . ASP A 1 195 ? -8.300  4.111   0.266   1.000 18.301  0  195 ASP A OD1   1 ? 
ATOM   1528 O OD2   . ASP A 1 195 ? -7.468  6.122   0.308   1.000 19.706  0  195 ASP A OD2   1 ? 
ATOM   1529 N N     . PHE A 1 196 ? -11.943 5.822   -2.977  1.000 12.413  0  196 PHE A N     1 ? 
ATOM   1530 C CA    . PHE A 1 196 ? -13.178 6.447   -3.481  1.000 12.808  0  196 PHE A CA    1 ? 
ATOM   1531 C C     . PHE A 1 196 ? -14.247 5.361   -3.771  1.000 13.633  0  196 PHE A C     1 ? 
ATOM   1532 O O     . PHE A 1 196 ? -15.440 5.573   -3.449  1.000 12.426  0  196 PHE A O     1 ? 
ATOM   1533 C CB    . PHE A 1 196 ? -12.878 7.326   -4.687  1.000 12.950  0  196 PHE A CB    1 ? 
ATOM   1534 C CG    . PHE A 1 196 ? -14.091 8.033   -5.221  1.000 13.283  0  196 PHE A CG    1 ? 
ATOM   1535 C CD1   . PHE A 1 196 ? -14.849 8.872   -4.391  1.000 14.822  0  196 PHE A CD1   1 ? 
ATOM   1536 C CD2   . PHE A 1 196 ? -14.534 7.797   -6.508  1.000 12.965  0  196 PHE A CD2   1 ? 
ATOM   1537 C CE1   . PHE A 1 196 ? -15.994 9.487   -4.882  1.000 14.710  0  196 PHE A CE1   1 ? 
ATOM   1538 C CE2   . PHE A 1 196 ? -15.660 8.443   -6.997  1.000 14.002  0  196 PHE A CE2   1 ? 
ATOM   1539 C CZ    . PHE A 1 196 ? -16.380 9.297   -6.191  1.000 14.580  0  196 PHE A CZ    1 ? 
ATOM   1540 N N     . ARG A 1 197 ? -13.875 4.256   -4.417  1.000 12.404  0  197 ARG A N     1 ? 
ATOM   1541 C CA    . ARG A 1 197 ? -14.885 3.299   -4.944  1.000 14.020  0  197 ARG A CA    1 ? 
ATOM   1542 C C     . ARG A 1 197 ? -15.033 2.053   -4.096  1.000 13.873  0  197 ARG A C     1 ? 
ATOM   1543 O O     . ARG A 1 197 ? -15.880 1.209   -4.484  1.000 14.004  0  197 ARG A O     1 ? 
ATOM   1544 C CB    . ARG A 1 197 ? -14.582 2.870   -6.372  1.000 14.980  0  197 ARG A CB    1 ? 
ATOM   1545 C CG    . ARG A 1 197 ? -14.530 4.022   -7.347  1.000 15.240  0  197 ARG A CG    1 ? 
ATOM   1546 C CD    . ARG A 1 197 ? -15.263 3.672   -8.598  1.000 17.832  0  197 ARG A CD    1 ? 
ATOM   1547 N NE    . ARG A 1 197 ? -16.711 3.644   -8.435  1.000 17.707  0  197 ARG A NE    1 ? 
ATOM   1548 C CZ    . ARG A 1 197 ? -17.541 2.991   -9.253  1.000 21.142  0  197 ARG A CZ    1 ? 
ATOM   1549 N NH1   . ARG A 1 197 ? -17.060 2.348   -10.310 1.000 21.597  0  197 ARG A NH1   1 ? 
ATOM   1550 N NH2   . ARG A 1 197 ? -18.855 3.031   -9.056  1.000 18.904  0  197 ARG A NH2   1 ? 
ATOM   1551 N N     . PHE A 1 198 ? -14.278 1.886   -3.014  1.000 13.161  0  198 PHE A N     1 ? 
ATOM   1552 C CA    . PHE A 1 198 ? -14.440 0.719   -2.121  1.000 15.487  0  198 PHE A CA    1 ? 
ATOM   1553 C C     . PHE A 1 198 ? -14.747 1.184   -0.693  1.000 17.272  0  198 PHE A C     1 ? 
ATOM   1554 O O     . PHE A 1 198 ? -14.331 0.484   0.261   1.000 20.311  0  198 PHE A O     1 ? 
ATOM   1555 C CB    . PHE A 1 198 ? -13.220 -0.209  -2.195  1.000 13.572  0  198 PHE A CB    1 ? 
ATOM   1556 C CG    . PHE A 1 198 ? -12.927 -0.809  -3.549  1.000 14.154  0  198 PHE A CG    1 ? 
ATOM   1557 C CD1   . PHE A 1 198 ? -12.418 -0.033  -4.583  1.000 13.597  0  198 PHE A CD1   1 ? 
ATOM   1558 C CD2   . PHE A 1 198 ? -13.103 -2.166  -3.780  1.000 13.658  0  198 PHE A CD2   1 ? 
ATOM   1559 C CE1   . PHE A 1 198 ? -12.102 -0.606  -5.808  1.000 13.701  0  198 PHE A CE1   1 ? 
ATOM   1560 C CE2   . PHE A 1 198 ? -12.790 -2.727  -5.004  1.000 13.617  0  198 PHE A CE2   1 ? 
ATOM   1561 C CZ    . PHE A 1 198 ? -12.327 -1.940  -6.027  1.000 14.245  0  198 PHE A CZ    1 ? 
ATOM   1562 N N     . SER A 1 199 ? -15.452 2.311   -0.552  1.000 21.058  0  199 SER A N     1 ? 
ATOM   1563 C CA    . SER A 1 199 ? -15.767 2.953   0.757   1.000 23.028  0  199 SER A CA    1 ? 
ATOM   1564 C C     . SER A 1 199 ? -16.972 2.285   1.430   1.000 25.051  0  199 SER A C     1 ? 
ATOM   1565 O O     . SER A 1 199 ? -17.119 2.476   2.648   1.000 23.942  0  199 SER A O     1 ? 
ATOM   1566 C CB    . SER A 1 199 ? -15.999 4.432   0.613   1.000 23.929  0  199 SER A CB    1 ? 
ATOM   1567 O OG    . SER A 1 199 ? -17.179 4.705   -0.126  1.000 27.355  0  199 SER A OG    1 ? 
ATOM   1568 N N     . SER A 1 200 ? -17.814 1.565   0.686   1.000 23.376  0  200 SER A N     1 ? 
ATOM   1569 C CA    . SER A 1 200 ? -19.038 0.898   1.228   1.000 27.060  0  200 SER A CA    1 ? 
ATOM   1570 C C     . SER A 1 200 ? -18.634 -0.205  2.189   1.000 28.735  0  200 SER A C     1 ? 
ATOM   1571 O O     . SER A 1 200 ? -19.328 -0.385  3.225   1.000 30.079  0  200 SER A O     1 ? 
ATOM   1572 C CB    . SER A 1 200 ? -19.902 0.340   0.151   1.000 28.167  0  200 SER A CB    1 ? 
ATOM   1573 O OG    . SER A 1 200 ? -20.446 1.381   -0.620  1.000 26.701  0  200 SER A OG    1 ? 
ATOM   1574 N N     . ASP A 1 201 ? -17.560 -0.917  1.826   1.000 26.420  0  201 ASP A N     1 ? 
ATOM   1575 C CA    . ASP A 1 201 ? -17.093 -2.160  2.474   1.000 26.943  0  201 ASP A CA    1 ? 
ATOM   1576 C C     . ASP A 1 201 ? -15.567 -2.200  2.433   1.000 24.741  0  201 ASP A C     1 ? 
ATOM   1577 O O     . ASP A 1 201 ? -15.054 -2.810  1.505   1.000 21.631  0  201 ASP A O     1 ? 
ATOM   1578 C CB    . ASP A 1 201 ? -17.670 -3.351  1.712   1.000 29.571  0  201 ASP A CB    1 ? 
ATOM   1579 C CG    . ASP A 1 201 ? -17.437 -4.691  2.355   1.000 34.209  0  201 ASP A CG    1 ? 
ATOM   1580 O OD1   . ASP A 1 201 ? -16.796 -4.732  3.447   1.000 34.798  0  201 ASP A OD1   1 ? 
ATOM   1581 O OD2   . ASP A 1 201 ? -17.931 -5.688  1.764   1.000 36.996  0  201 ASP A OD2   1 ? 
ATOM   1582 N N     . GLY A 1 202 ? -14.894 -1.637  3.441   1.000 26.690  0  202 GLY A N     1 ? 
ATOM   1583 C CA    . GLY A 1 202 ? -13.421 -1.593  3.578   1.000 28.316  0  202 GLY A CA    1 ? 
ATOM   1584 C C     . GLY A 1 202 ? -12.750 -2.948  3.419   1.000 29.067  0  202 GLY A C     1 ? 
ATOM   1585 O O     . GLY A 1 202 ? -11.634 -2.980  2.880   1.000 28.392  0  202 GLY A O     1 ? 
ATOM   1586 N N     . ASN A 1 203 ? -13.385 -4.033  3.872   1.000 30.351  0  203 ASN A N     1 ? 
ATOM   1587 C CA    . ASN A 1 203 ? -12.852 -5.427  3.795   1.000 33.572  0  203 ASN A CA    1 ? 
ATOM   1588 C C     . ASN A 1 203 ? -12.699 -5.881  2.345   1.000 30.001  0  203 ASN A C     1 ? 
ATOM   1589 O O     . ASN A 1 203 ? -11.811 -6.688  2.076   1.000 33.423  0  203 ASN A O     1 ? 
ATOM   1590 C CB    . ASN A 1 203 ? -13.771 -6.433  4.494   1.000 39.996  0  203 ASN A CB    1 ? 
ATOM   1591 C CG    . ASN A 1 203 ? -13.812 -6.234  5.995   1.000 43.210  0  203 ASN A CG    1 ? 
ATOM   1592 O OD1   . ASN A 1 203 ? -14.879 -6.009  6.571   1.000 49.983  0  203 ASN A OD1   1 ? 
ATOM   1593 N ND2   . ASN A 1 203 ? -12.652 -6.292  6.623   1.000 42.374  0  203 ASN A ND2   1 ? 
ATOM   1594 N N     . ALA A 1 204 ? -13.598 -5.432  1.470   1.000 26.720  0  204 ALA A N     1 ? 
ATOM   1595 C CA    . ALA A 1 204 ? -13.611 -5.742  0.029   1.000 24.019  0  204 ALA A CA    1 ? 
ATOM   1596 C C     . ALA A 1 204 ? -12.493 -4.979  -0.693  1.000 23.278  0  204 ALA A C     1 ? 
ATOM   1597 O O     . ALA A 1 204 ? -12.232 -5.329  -1.838  1.000 26.001  0  204 ALA A O     1 ? 
ATOM   1598 C CB    . ALA A 1 204 ? -14.972 -5.400  -0.551  1.000 24.899  0  204 ALA A CB    1 ? 
ATOM   1599 N N     . ALA A 1 205 ? -11.929 -3.910  -0.093  1.000 23.448  0  205 ALA A N     1 ? 
ATOM   1600 C CA    . ALA A 1 205 ? -10.967 -3.016  -0.783  1.000 21.446  0  205 ALA A CA    1 ? 
ATOM   1601 C C     . ALA A 1 205 ? -9.657  -3.775  -1.006  1.000 21.167  0  205 ALA A C     1 ? 
ATOM   1602 O O     . ALA A 1 205 ? -9.134  -4.389  -0.085  1.000 20.408  0  205 ALA A O     1 ? 
ATOM   1603 C CB    . ALA A 1 205 ? -10.755 -1.728  -0.020  1.000 23.018  0  205 ALA A CB    1 ? 
ATOM   1604 N N     . PRO A 1 206 ? -9.092  -3.754  -2.231  1.000 19.875  0  206 PRO A N     1 ? 
ATOM   1605 C CA    . PRO A 1 206 ? -7.736  -4.251  -2.460  1.000 20.448  0  206 PRO A CA    1 ? 
ATOM   1606 C C     . PRO A 1 206 ? -6.692  -3.530  -1.587  1.000 20.768  0  206 PRO A C     1 ? 
ATOM   1607 O O     . PRO A 1 206 ? -6.634  -2.315  -1.623  1.000 20.137  0  206 PRO A O     1 ? 
ATOM   1608 C CB    . PRO A 1 206 ? -7.499  -3.967  -3.943  1.000 20.510  0  206 PRO A CB    1 ? 
ATOM   1609 C CG    . PRO A 1 206 ? -8.478  -2.902  -4.297  1.000 23.875  0  206 PRO A CG    1 ? 
ATOM   1610 C CD    . PRO A 1 206 ? -9.690  -3.166  -3.430  1.000 20.985  0  206 PRO A CD    1 ? 
ATOM   1611 N N     . LEU A 1 207 ? -5.894  -4.272  -0.814  1.000 18.724  0  207 LEU A N     1 ? 
ATOM   1612 C CA    . LEU A 1 207 ? -4.846  -3.674  0.048   1.000 20.360  0  207 LEU A CA    1 ? 
ATOM   1613 C C     . LEU A 1 207 ? -3.890  -2.822  -0.799  1.000 19.327  0  207 LEU A C     1 ? 
ATOM   1614 O O     . LEU A 1 207 ? -3.554  -3.257  -1.907  1.000 19.147  0  207 LEU A O     1 ? 
ATOM   1615 C CB    . LEU A 1 207 ? -4.069  -4.795  0.745   1.000 23.392  0  207 LEU A CB    1 ? 
ATOM   1616 C CG    . LEU A 1 207 ? -4.823  -5.540  1.839   1.000 25.519  0  207 LEU A CG    1 ? 
ATOM   1617 C CD1   . LEU A 1 207 ? -4.024  -6.759  2.274   1.000 27.748  0  207 LEU A CD1   1 ? 
ATOM   1618 C CD2   . LEU A 1 207 ? -5.094  -4.620  3.025   1.000 27.255  0  207 LEU A CD2   1 ? 
ATOM   1619 N N     . GLY A 1 208 ? -3.463  -1.664  -0.273  1.000 18.056  0  208 GLY A N     1 ? 
ATOM   1620 C CA    . GLY A 1 208 ? -2.405  -0.813  -0.851  1.000 18.944  0  208 GLY A CA    1 ? 
ATOM   1621 C C     . GLY A 1 208 ? -1.203  -1.633  -1.301  1.000 16.620  0  208 GLY A C     1 ? 
ATOM   1622 O O     . GLY A 1 208 ? -0.677  -1.360  -2.388  1.000 16.235  0  208 GLY A O     1 ? 
ATOM   1623 N N     . ILE A 1 209 ? -0.755  -2.571  -0.468  1.000 16.323  0  209 ILE A N     1 ? 
ATOM   1624 C CA    . ILE A 1 209 ? 0.462   -3.396  -0.735  1.000 17.305  0  209 ILE A CA    1 ? 
ATOM   1625 C C     . ILE A 1 209 ? 0.239   -4.263  -1.985  1.000 15.199  0  209 ILE A C     1 ? 
ATOM   1626 O O     . ILE A 1 209 ? 1.202   -4.461  -2.788  1.000 13.554  0  209 ILE A O     1 ? 
ATOM   1627 C CB    . ILE A 1 209 ? 0.860   -4.248  0.494   1.000 21.742  0  209 ILE A CB    1 ? 
ATOM   1628 C CG1   . ILE A 1 209 ? 2.246   -4.844  0.297   1.000 26.623  0  209 ILE A CG1   1 ? 
ATOM   1629 C CG2   . ILE A 1 209 ? -0.148  -5.351  0.763   1.000 24.674  0  209 ILE A CG2   1 ? 
ATOM   1630 C CD1   . ILE A 1 209 ? 3.278   -3.826  0.109   1.000 29.877  0  209 ILE A CD1   1 ? 
ATOM   1631 N N     . GLY A 1 210 ? -0.986  -4.717  -2.188  1.000 13.765  0  210 GLY A N     1 ? 
ATOM   1632 C CA    . GLY A 1 210 ? -1.367  -5.488  -3.381  1.000 14.836  0  210 GLY A CA    1 ? 
ATOM   1633 C C     . GLY A 1 210 ? -1.332  -4.646  -4.645  1.000 13.698  0  210 GLY A C     1 ? 
ATOM   1634 O O     . GLY A 1 210 ? -0.855  -5.137  -5.649  1.000 12.309  0  210 GLY A O     1 ? 
ATOM   1635 N N     . LEU A 1 211 ? -1.824  -3.400  -4.604  1.000 12.818  0  211 LEU A N     1 ? 
ATOM   1636 C CA    . LEU A 1 211 ? -1.743  -2.492  -5.771  1.000 12.951  0  211 LEU A CA    1 ? 
ATOM   1637 C C     . LEU A 1 211 ? -0.264  -2.188  -6.059  1.000 11.377  0  211 LEU A C     1 ? 
ATOM   1638 O O     . LEU A 1 211 ? 0.101   -2.118  -7.227  1.000 9.578   0  211 LEU A O     1 ? 
ATOM   1639 C CB    . LEU A 1 211 ? -2.547  -1.220  -5.469  1.000 14.010  0  211 LEU A CB    1 ? 
ATOM   1640 C CG    . LEU A 1 211 ? -4.034  -1.463  -5.153  1.000 14.028  0  211 LEU A CG    1 ? 
ATOM   1641 C CD1   . LEU A 1 211 ? -4.680  -0.177  -4.695  1.000 14.773  0  211 LEU A CD1   1 ? 
ATOM   1642 C CD2   . LEU A 1 211 ? -4.749  -2.030  -6.361  1.000 14.696  0  211 LEU A CD2   1 ? 
ATOM   1643 N N     . THR A 1 212 ? 0.559   -2.037  -5.021  1.000 11.486  0  212 THR A N     1 ? 
ATOM   1644 C CA    . THR A 1 212 ? 2.000   -1.730  -5.157  1.000 11.695  0  212 THR A CA    1 ? 
ATOM   1645 C C     . THR A 1 212 ? 2.721   -2.938  -5.828  1.000 12.272  0  212 THR A C     1 ? 
ATOM   1646 O O     . THR A 1 212 ? 3.444   -2.756  -6.803  1.000 10.789  0  212 THR A O     1 ? 
ATOM   1647 C CB    . THR A 1 212 ? 2.551   -1.346  -3.788  1.000 11.829  0  212 THR A CB    1 ? 
ATOM   1648 O OG1   . THR A 1 212 ? 1.792   -0.210  -3.349  1.000 12.304  0  212 THR A OG1   1 ? 
ATOM   1649 C CG2   . THR A 1 212 ? 4.016   -1.005  -3.808  1.000 12.586  0  212 THR A CG2   1 ? 
ATOM   1650 N N     . ALA A 1 213 ? 2.490   -4.125  -5.304  1.000 11.832  0  213 ALA A N     1 ? 
ATOM   1651 C CA    . ALA A 1 213 ? 3.055   -5.371  -5.852  1.000 12.111  0  213 ALA A CA    1 ? 
ATOM   1652 C C     . ALA A 1 213 ? 2.547   -5.566  -7.293  1.000 11.435  0  213 ALA A C     1 ? 
ATOM   1653 O O     . ALA A 1 213 ? 3.368   -5.896  -8.157  1.000 10.289  0  213 ALA A O     1 ? 
ATOM   1654 C CB    . ALA A 1 213 ? 2.739   -6.504  -4.941  1.000 11.868  0  213 ALA A CB    1 ? 
ATOM   1655 N N     . ALA A 1 214 ? 1.262   -5.313  -7.570  1.000 11.751  0  214 ALA A N     1 ? 
ATOM   1656 C CA    . ALA A 1 214 ? 0.706   -5.417  -8.947  1.000 11.653  0  214 ALA A CA    1 ? 
ATOM   1657 C C     . ALA A 1 214 ? 1.501   -4.489  -9.876  1.000 11.703  0  214 ALA A C     1 ? 
ATOM   1658 O O     . ALA A 1 214 ? 1.918   -4.952  -10.965 1.000 11.794  0  214 ALA A O     1 ? 
ATOM   1659 C CB    . ALA A 1 214 ? -0.775  -5.138  -8.980  1.000 12.376  0  214 ALA A CB    1 ? 
ATOM   1660 N N     . ALA A 1 215 ? 1.764   -3.236  -9.452  1.000 10.987  0  215 ALA A N     1 ? 
ATOM   1661 C CA    . ALA A 1 215 ? 2.559   -2.268  -10.228 1.000 10.191  0  215 ALA A CA    1 ? 
ATOM   1662 C C     . ALA A 1 215 ? 3.977   -2.826  -10.430 1.000 10.486  0  215 ALA A C     1 ? 
ATOM   1663 O O     . ALA A 1 215 ? 4.492   -2.764  -11.561 1.000 10.609  0  215 ALA A O     1 ? 
ATOM   1664 C CB    . ALA A 1 215 ? 2.535   -0.899  -9.561  1.000 9.975   0  215 ALA A CB    1 ? 
ATOM   1665 N N     . TYR A 1 216 ? 4.599   -3.389  -9.394  1.000 10.912  0  216 TYR A N     1 ? 
ATOM   1666 C CA    . TYR A 1 216 ? 5.925   -4.015  -9.518  1.000 11.472  0  216 TYR A CA    1 ? 
ATOM   1667 C C     . TYR A 1 216 ? 5.915   -5.044  -10.661 1.000 12.377  0  216 TYR A C     1 ? 
ATOM   1668 O O     . TYR A 1 216 ? 6.852   -5.046  -11.515 1.000 11.259  0  216 TYR A O     1 ? 
ATOM   1669 C CB    . TYR A 1 216 ? 6.321   -4.675  -8.204  1.000 13.164  0  216 TYR A CB    1 ? 
ATOM   1670 C CG    . TYR A 1 216 ? 7.574   -5.488  -8.337  1.000 12.927  0  216 TYR A CG    1 ? 
ATOM   1671 C CD1   . TYR A 1 216 ? 8.821   -4.883  -8.239  1.000 14.283  0  216 TYR A CD1   1 ? 
ATOM   1672 C CD2   . TYR A 1 216 ? 7.528   -6.843  -8.650  1.000 14.574  0  216 TYR A CD2   1 ? 
ATOM   1673 C CE1   . TYR A 1 216 ? 9.988   -5.618  -8.378  1.000 14.929  0  216 TYR A CE1   1 ? 
ATOM   1674 C CE2   . TYR A 1 216 ? 8.697   -7.579  -8.831  1.000 16.224  0  216 TYR A CE2   1 ? 
ATOM   1675 C CZ    . TYR A 1 216 ? 9.928   -6.959  -8.704  1.000 15.497  0  216 TYR A CZ    1 ? 
ATOM   1676 O OH    . TYR A 1 216 ? 11.080  -7.683  -8.861  1.000 20.847  0  216 TYR A OH    1 ? 
ATOM   1677 N N     . TRP A 1 217 ? 4.908   -5.910  -10.698 1.000 12.016  0  217 TRP A N     1 ? 
ATOM   1678 C CA    . TRP A 1 217 ? 4.861   -6.971  -11.746 1.000 13.978  0  217 TRP A CA    1 ? 
ATOM   1679 C C     . TRP A 1 217 ? 4.553   -6.398  -13.134 1.000 13.263  0  217 TRP A C     1 ? 
ATOM   1680 O O     . TRP A 1 217 ? 5.160   -6.858  -14.101 1.000 13.420  0  217 TRP A O     1 ? 
ATOM   1681 C CB    . TRP A 1 217 ? 3.879   -8.078  -11.375 1.000 13.465  0  217 TRP A CB    1 ? 
ATOM   1682 C CG    . TRP A 1 217 ? 4.282   -8.862  -10.179 1.000 13.902  0  217 TRP A CG    1 ? 
ATOM   1683 C CD1   . TRP A 1 217 ? 3.600   -8.970  -9.009  1.000 13.788  0  217 TRP A CD1   1 ? 
ATOM   1684 C CD2   . TRP A 1 217 ? 5.458   -9.675  -10.040 1.000 15.086  0  217 TRP A CD2   1 ? 
ATOM   1685 N NE1   . TRP A 1 217 ? 4.257   -9.804  -8.154  1.000 14.242  0  217 TRP A NE1   1 ? 
ATOM   1686 C CE2   . TRP A 1 217 ? 5.412   -10.234 -8.746  1.000 15.582  0  217 TRP A CE2   1 ? 
ATOM   1687 C CE3   . TRP A 1 217 ? 6.512   -10.015 -10.896 1.000 16.162  0  217 TRP A CE3   1 ? 
ATOM   1688 C CZ2   . TRP A 1 217 ? 6.399   -11.098 -8.273  1.000 16.008  0  217 TRP A CZ2   1 ? 
ATOM   1689 C CZ3   . TRP A 1 217 ? 7.485   -10.874 -10.424 1.000 18.154  0  217 TRP A CZ3   1 ? 
ATOM   1690 C CH2   . TRP A 1 217 ? 7.425   -11.401 -9.136  1.000 16.886  0  217 TRP A CH2   1 ? 
ATOM   1691 N N     . TRP A 1 218 ? 3.653   -5.430  -13.253 1.000 12.526  0  218 TRP A N     1 ? 
ATOM   1692 C CA    . TRP A 1 218 ? 2.931   -5.190  -14.522 1.000 11.973  0  218 TRP A CA    1 ? 
ATOM   1693 C C     . TRP A 1 218 ? 3.042   -3.749  -15.029 1.000 12.451  0  218 TRP A C     1 ? 
ATOM   1694 O O     . TRP A 1 218 ? 2.661   -3.520  -16.177 1.000 13.392  0  218 TRP A O     1 ? 
ATOM   1695 C CB    . TRP A 1 218 ? 1.481   -5.638  -14.348 1.000 12.684  0  218 TRP A CB    1 ? 
ATOM   1696 C CG    . TRP A 1 218 ? 1.340   -7.126  -14.130 1.000 12.335  0  218 TRP A CG    1 ? 
ATOM   1697 C CD1   . TRP A 1 218 ? 1.965   -8.135  -14.807 1.000 14.203  0  218 TRP A CD1   1 ? 
ATOM   1698 C CD2   . TRP A 1 218 ? 0.508   -7.769  -13.155 1.000 13.457  0  218 TRP A CD2   1 ? 
ATOM   1699 N NE1   . TRP A 1 218 ? 1.606   -9.365  -14.301 1.000 13.733  0  218 TRP A NE1   1 ? 
ATOM   1700 C CE2   . TRP A 1 218 ? 0.666   -9.170  -13.321 1.000 13.392  0  218 TRP A CE2   1 ? 
ATOM   1701 C CE3   . TRP A 1 218 ? -0.368  -7.296  -12.169 1.000 12.964  0  218 TRP A CE3   1 ? 
ATOM   1702 C CZ2   . TRP A 1 218 ? -0.004  -10.087 -12.516 1.000 14.673  0  218 TRP A CZ2   1 ? 
ATOM   1703 C CZ3   . TRP A 1 218 ? -1.031  -8.211  -11.381 1.000 14.406  0  218 TRP A CZ3   1 ? 
ATOM   1704 C CH2   . TRP A 1 218 ? -0.869  -9.584  -11.569 1.000 13.799  0  218 TRP A CH2   1 ? 
ATOM   1705 N N     . PHE A 1 219 ? 3.455   -2.773  -14.223 1.000 12.128  0  219 PHE A N     1 ? 
ATOM   1706 C CA    . PHE A 1 219 ? 3.471   -1.368  -14.707 1.000 11.493  0  219 PHE A CA    1 ? 
ATOM   1707 C C     . PHE A 1 219 ? 4.526   -1.218  -15.810 1.000 12.090  0  219 PHE A C     1 ? 
ATOM   1708 O O     . PHE A 1 219 ? 5.670   -1.751  -15.688 1.000 13.653  0  219 PHE A O     1 ? 
ATOM   1709 C CB    . PHE A 1 219 ? 3.766   -0.377  -13.585 1.000 11.477  0  219 PHE A CB    1 ? 
ATOM   1710 C CG    . PHE A 1 219 ? 4.001   1.025   -14.053 1.000 11.367  0  219 PHE A CG    1 ? 
ATOM   1711 C CD1   . PHE A 1 219 ? 2.940   1.879   -14.270 1.000 12.210  0  219 PHE A CD1   1 ? 
ATOM   1712 C CD2   . PHE A 1 219 ? 5.272   1.486   -14.293 1.000 12.473  0  219 PHE A CD2   1 ? 
ATOM   1713 C CE1   . PHE A 1 219 ? 3.154   3.182   -14.697 1.000 13.013  0  219 PHE A CE1   1 ? 
ATOM   1714 C CE2   . PHE A 1 219 ? 5.488   2.791   -14.724 1.000 12.760  0  219 PHE A CE2   1 ? 
ATOM   1715 C CZ    . PHE A 1 219 ? 4.427   3.623   -14.957 1.000 12.567  0  219 PHE A CZ    1 ? 
ATOM   1716 N N     . GLN A 1 220 ? 4.153   -0.530  -16.879 1.000 12.671  0  220 GLN A N     1 ? 
ATOM   1717 C CA    . GLN A 1 220 ? 5.103   -0.066  -17.922 1.000 13.224  0  220 GLN A CA    1 ? 
ATOM   1718 C C     . GLN A 1 220 ? 5.023   1.443   -18.057 1.000 11.973  0  220 GLN A C     1 ? 
ATOM   1719 O O     . GLN A 1 220 ? 3.901   1.987   -18.176 1.000 12.710  0  220 GLN A O     1 ? 
ATOM   1720 C CB    . GLN A 1 220 ? 4.767   -0.704  -19.262 1.000 16.013  0  220 GLN A CB    1 ? 
ATOM   1721 C CG    . GLN A 1 220 ? 4.736   -2.208  -19.177 1.000 19.382  0  220 GLN A CG    1 ? 
ATOM   1722 C CD    . GLN A 1 220 ? 6.126   -2.759  -19.089 1.000 25.645  0  220 GLN A CD    1 ? 
ATOM   1723 O OE1   . GLN A 1 220 ? 7.097   -2.094  -19.470 1.000 31.234  0  220 GLN A OE1   1 ? 
ATOM   1724 N NE2   . GLN A 1 220 ? 6.224   -3.990  -18.604 1.000 32.361  0  220 GLN A NE2   1 ? 
ATOM   1725 N N     . VAL A 1 221 ? 6.172   2.071   -18.194 1.000 13.146  0  221 VAL A N     1 ? 
ATOM   1726 C CA    . VAL A 1 221 ? 6.288   3.524   -18.460 1.000 13.482  0  221 VAL A CA    1 ? 
ATOM   1727 C C     . VAL A 1 221 ? 5.567   3.805   -19.770 1.000 13.661  0  221 VAL A C     1 ? 
ATOM   1728 O O     . VAL A 1 221 ? 5.649   2.972   -20.698 1.000 13.792  0  221 VAL A O     1 ? 
ATOM   1729 C CB    . VAL A 1 221 ? 7.758   3.979   -18.511 1.000 15.802  0  221 VAL A CB    1 ? 
ATOM   1730 C CG1   . VAL A 1 221 ? 7.893   5.388   -19.005 1.000 16.794  0  221 VAL A CG1   1 ? 
ATOM   1731 C CG2   . VAL A 1 221 ? 8.426   3.835   -17.163 1.000 17.227  0  221 VAL A CG2   1 ? 
ATOM   1732 N N     . SER A 1 222 ? 4.882   4.921   -19.853 1.000 12.559  0  222 SER A N     1 ? 
ATOM   1733 C CA    . SER A 1 222 ? 4.399   5.500   -21.146 1.000 13.786  0  222 SER A CA    1 ? 
ATOM   1734 C C     . SER A 1 222 ? 4.917   6.928   -21.299 1.000 14.578  0  222 SER A C     1 ? 
ATOM   1735 O O     . SER A 1 222 ? 4.546   7.821   -20.520 1.000 12.609  0  222 SER A O     1 ? 
ATOM   1736 C CB    . SER A 1 222 ? 2.910   5.441   -21.265 1.000 14.154  0  222 SER A CB    1 ? 
ATOM   1737 O OG    . SER A 1 222 ? 2.510   6.002   -22.484 1.000 14.178  0  222 SER A OG    1 ? 
ATOM   1738 N N     . LYS A 1 223 ? 5.734   7.144   -22.317 1.000 16.355  0  223 LYS A N     1 ? 
ATOM   1739 C CA    . LYS A 1 223 ? 6.358   8.447   -22.565 1.000 17.461  0  223 LYS A CA    1 ? 
ATOM   1740 C C     . LYS A 1 223 ? 6.646   8.575   -24.072 1.000 20.277  0  223 LYS A C     1 ? 
ATOM   1741 O O     . LYS A 1 223 ? 6.774   7.549   -24.738 1.000 19.755  0  223 LYS A O     1 ? 
ATOM   1742 C CB    . LYS A 1 223 ? 7.622   8.600   -21.725 1.000 17.163  0  223 LYS A CB    1 ? 
ATOM   1743 C CG    . LYS A 1 223 ? 8.757   7.643   -22.039 1.000 16.914  0  223 LYS A CG    1 ? 
ATOM   1744 C CD    . LYS A 1 223 ? 9.938   7.839   -21.112 1.000 16.611  0  223 LYS A CD    1 ? 
ATOM   1745 C CE    . LYS A 1 223 ? 10.953  6.730   -21.247 1.000 17.183  0  223 LYS A CE    1 ? 
ATOM   1746 N NZ    . LYS A 1 223 ? 12.087  6.942   -20.329 1.000 18.268  0  223 LYS A NZ    1 ? 
ATOM   1747 N N     . ARG A 1 224 ? 6.729   9.802   -24.557 1.000 25.758  0  224 ARG A N     1 ? 
ATOM   1748 C CA    . ARG A 1 224 ? 7.090   10.077  -25.966 1.000 29.436  0  224 ARG A CA    1 ? 
ATOM   1749 C C     . ARG A 1 224 ? 8.197   11.118  -25.990 1.000 30.873  0  224 ARG A C     1 ? 
ATOM   1750 O O     . ARG A 1 224 ? 8.191   12.047  -25.133 1.000 29.920  0  224 ARG A O     1 ? 
ATOM   1751 C CB    . ARG A 1 224 ? 5.886   10.557  -26.767 1.000 34.144  0  224 ARG A CB    1 ? 
ATOM   1752 C CG    . ARG A 1 224 ? 4.928   9.456   -27.203 1.000 45.188  0  224 ARG A CG    1 ? 
ATOM   1753 C CD    . ARG A 1 224 ? 4.422   9.602   -28.634 1.000 49.962  0  224 ARG A CD    1 ? 
ATOM   1754 N NE    . ARG A 1 224 ? 4.845   10.858  -29.249 1.000 53.486  0  224 ARG A NE    1 ? 
ATOM   1755 C CZ    . ARG A 1 224 ? 4.122   11.980  -29.317 1.000 57.129  0  224 ARG A CZ    1 ? 
ATOM   1756 N NH1   . ARG A 1 224 ? 2.897   12.036  -28.818 1.000 60.345  0  224 ARG A NH1   1 ? 
ATOM   1757 N NH2   . ARG A 1 224 ? 4.640   13.052  -29.890 1.000 55.328  0  224 ARG A NH2   1 ? 
ATOM   1758 N N     . THR A 1 225 ? 9.087   10.952  -26.961 1.000 35.253  0  225 THR A N     1 ? 
ATOM   1759 C CA    . THR A 1 225 ? 10.373  11.658  -27.086 1.000 37.165  0  225 THR A CA    1 ? 
ATOM   1760 C C     . THR A 1 225 ? 10.328  12.352  -28.434 1.000 36.591  0  225 THR A C     1 ? 
ATOM   1761 O O     . THR A 1 225 ? 10.239  11.634  -29.425 1.000 35.675  0  225 THR A O     1 ? 
ATOM   1762 C CB    . THR A 1 225 ? 11.515  10.650  -26.916 1.000 42.915  0  225 THR A CB    1 ? 
ATOM   1763 O OG1   . THR A 1 225 ? 11.235  9.915   -25.718 1.000 47.100  0  225 THR A OG1   1 ? 
ATOM   1764 C CG2   . THR A 1 225 ? 12.884  11.294  -26.868 1.000 44.224  0  225 THR A CG2   1 ? 
ATOM   1765 N N     . ASP A 1 226 ? 10.196  13.675  -28.435 1.000 43.694  0  226 ASP A N     1 ? 
ATOM   1766 C CA    . ASP A 1 226 ? 9.990   14.508  -29.652 1.000 46.871  0  226 ASP A CA    1 ? 
ATOM   1767 C C     . ASP A 1 226 ? 11.076  14.196  -30.687 1.000 47.415  0  226 ASP A C     1 ? 
ATOM   1768 O O     . ASP A 1 226 ? 12.256  14.078  -30.349 1.000 45.607  0  226 ASP A O     1 ? 
ATOM   1769 C CB    . ASP A 1 226 ? 9.979   16.001  -29.312 1.000 44.860  0  226 ASP A CB    1 ? 
ATOM   1770 C CG    . ASP A 1 226 ? 9.378   16.840  -30.415 1.000 46.656  0  226 ASP A CG    1 ? 
ATOM   1771 O OD1   . ASP A 1 226 ? 10.052  17.784  -30.877 1.000 55.294  0  226 ASP A OD1   1 ? 
ATOM   1772 O OD2   . ASP A 1 226 ? 8.263   16.503  -30.840 1.000 49.689  0  226 ASP A OD2   1 ? 
ATOM   1773 N N     . PRO A 1 227 ? 10.738  14.080  -31.991 1.000 47.802  0  227 PRO A N     1 ? 
ATOM   1774 C CA    . PRO A 1 227 ? 11.749  13.790  -33.008 1.000 48.709  0  227 PRO A CA    1 ? 
ATOM   1775 C C     . PRO A 1 227 ? 12.762  14.938  -33.174 1.000 51.740  0  227 PRO A C     1 ? 
ATOM   1776 O O     . PRO A 1 227 ? 13.781  14.718  -33.817 1.000 51.385  0  227 PRO A O     1 ? 
ATOM   1777 C CB    . PRO A 1 227 ? 10.951  13.613  -34.314 1.000 50.425  0  227 PRO A CB    1 ? 
ATOM   1778 C CG    . PRO A 1 227 ? 9.490   13.505  -33.886 1.000 49.863  0  227 PRO A CG    1 ? 
ATOM   1779 C CD    . PRO A 1 227 ? 9.395   14.243  -32.566 1.000 50.890  0  227 PRO A CD    1 ? 
ATOM   1780 N N     . VAL A 1 228 ? 12.457  16.125  -32.625 1.000 51.918  0  228 VAL A N     1 ? 
ATOM   1781 C CA    . VAL A 1 228 ? 13.218  17.388  -32.868 1.000 53.063  0  228 VAL A CA    1 ? 
ATOM   1782 C C     . VAL A 1 228 ? 13.975  17.773  -31.590 1.000 48.520  0  228 VAL A C     1 ? 
ATOM   1783 O O     . VAL A 1 228 ? 15.214  17.709  -31.604 1.000 54.070  0  228 VAL A O     1 ? 
ATOM   1784 C CB    . VAL A 1 228 ? 12.301  18.530  -33.358 1.000 57.970  0  228 VAL A CB    1 ? 
ATOM   1785 C CG1   . VAL A 1 228 ? 13.108  19.652  -34.008 1.000 56.020  0  228 VAL A CG1   1 ? 
ATOM   1786 C CG2   . VAL A 1 228 ? 11.220  18.025  -34.309 1.000 58.276  0  228 VAL A CG2   1 ? 
ATOM   1787 N N     . SER A 1 229 ? 13.263  18.177  -30.540 1.000 43.330  0  229 SER A N     1 ? 
ATOM   1788 C CA    . SER A 1 229 ? 13.849  18.657  -29.258 1.000 41.322  0  229 SER A CA    1 ? 
ATOM   1789 C C     . SER A 1 229 ? 14.444  17.479  -28.472 1.000 42.056  0  229 SER A C     1 ? 
ATOM   1790 O O     . SER A 1 229 ? 15.270  17.728  -27.580 1.000 40.554  0  229 SER A O     1 ? 
ATOM   1791 C CB    . SER A 1 229 ? 12.814  19.349  -28.438 1.000 39.474  0  229 SER A CB    1 ? 
ATOM   1792 O OG    . SER A 1 229 ? 11.785  18.432  -28.161 1.000 35.452  0  229 SER A OG    1 ? 
ATOM   1793 N N     . GLN A 1 230 ? 13.998  16.257  -28.773 1.000 43.340  0  230 GLN A N     1 ? 
ATOM   1794 C CA    . GLN A 1 230 ? 14.225  15.027  -27.964 1.000 50.892  0  230 GLN A CA    1 ? 
ATOM   1795 C C     . GLN A 1 230 ? 13.591  15.198  -26.570 1.000 44.525  0  230 GLN A C     1 ? 
ATOM   1796 O O     . GLN A 1 230 ? 13.846  14.315  -25.717 1.000 48.864  0  230 GLN A O     1 ? 
ATOM   1797 C CB    . GLN A 1 230 ? 15.723  14.690  -27.891 1.000 55.065  0  230 GLN A CB    1 ? 
ATOM   1798 C CG    . GLN A 1 230 ? 16.324  14.271  -29.227 1.000 59.537  0  230 GLN A CG    1 ? 
ATOM   1799 C CD    . GLN A 1 230 ? 15.468  13.251  -29.941 1.000 68.521  0  230 GLN A CD    1 ? 
ATOM   1800 O OE1   . GLN A 1 230 ? 15.015  13.465  -31.067 1.000 66.748  0  230 GLN A OE1   1 ? 
ATOM   1801 N NE2   . GLN A 1 230 ? 15.203  12.140  -29.270 1.000 77.109  0  230 GLN A NE2   1 ? 
ATOM   1802 N N     . ASN A 1 231 ? 12.770  16.251  -26.380 1.000 38.582  0  231 ASN A N     1 ? 
ATOM   1803 C CA    . ASN A 1 231 ? 12.055  16.594  -25.116 1.000 37.071  0  231 ASN A CA    1 ? 
ATOM   1804 C C     . ASN A 1 231 ? 11.022  15.519  -24.760 1.000 34.300  0  231 ASN A C     1 ? 
ATOM   1805 O O     . ASN A 1 231 ? 10.208  15.149  -25.642 1.000 28.163  0  231 ASN A O     1 ? 
ATOM   1806 C CB    . ASN A 1 231 ? 11.306  17.913  -25.222 1.000 37.563  0  231 ASN A CB    1 ? 
ATOM   1807 C CG    . ASN A 1 231 ? 10.626  18.263  -23.924 1.000 41.405  0  231 ASN A CG    1 ? 
ATOM   1808 O OD1   . ASN A 1 231 ? 11.230  18.162  -22.867 1.000 56.623  0  231 ASN A OD1   1 ? 
ATOM   1809 N ND2   . ASN A 1 231 ? 9.359   18.628  -23.978 1.000 47.348  0  231 ASN A ND2   1 ? 
ATOM   1810 N N     . VAL A 1 232 ? 10.979  15.098  -23.493 1.000 26.576  0  232 VAL A N     1 ? 
ATOM   1811 C CA    . VAL A 1 232 ? 10.209  13.888  -23.085 1.000 26.550  0  232 VAL A CA    1 ? 
ATOM   1812 C C     . VAL A 1 232 ? 8.960   14.319  -22.328 1.000 22.768  0  232 VAL A C     1 ? 
ATOM   1813 O O     . VAL A 1 232 ? 9.059   15.194  -21.463 1.000 19.569  0  232 VAL A O     1 ? 
ATOM   1814 C CB    . VAL A 1 232 ? 11.077  12.920  -22.268 1.000 29.411  0  232 VAL A CB    1 ? 
ATOM   1815 C CG1   . VAL A 1 232 ? 10.243  11.842  -21.588 1.000 28.731  0  232 VAL A CG1   1 ? 
ATOM   1816 C CG2   . VAL A 1 232 ? 12.153  12.304  -23.148 1.000 30.831  0  232 VAL A CG2   1 ? 
ATOM   1817 N N     . THR A 1 233 ? 7.812   13.761  -22.705 1.000 21.515  0  233 THR A N     1 ? 
ATOM   1818 C CA    . THR A 1 233 ? 6.514   14.022  -22.038 1.000 22.464  0  233 THR A CA    1 ? 
ATOM   1819 C C     . THR A 1 233 ? 5.907   12.680  -21.635 1.000 19.538  0  233 THR A C     1 ? 
ATOM   1820 O O     . THR A 1 233 ? 5.923   11.754  -22.433 1.000 18.100  0  233 THR A O     1 ? 
ATOM   1821 C CB    . THR A 1 233 ? 5.526   14.783  -22.936 1.000 26.509  0  233 THR A CB    1 ? 
ATOM   1822 O OG1   . THR A 1 233 ? 5.523   14.082  -24.188 1.000 31.068  0  233 THR A OG1   1 ? 
ATOM   1823 C CG2   . THR A 1 233 ? 5.894   16.242  -23.112 1.000 30.890  0  233 THR A CG2   1 ? 
ATOM   1824 N N     . TYR A 1 234 ? 5.361   12.605  -20.435 1.000 16.412  0  234 TYR A N     1 ? 
ATOM   1825 C CA    . TYR A 1 234 ? 4.829   11.337  -19.887 1.000 15.209  0  234 TYR A CA    1 ? 
ATOM   1826 C C     . TYR A 1 234 ? 3.341   11.290  -20.184 1.000 13.990  0  234 TYR A C     1 ? 
ATOM   1827 O O     . TYR A 1 234 ? 2.741   12.320  -20.315 1.000 13.049  0  234 TYR A O     1 ? 
ATOM   1828 C CB    . TYR A 1 234 ? 5.175   11.218  -18.400 1.000 15.562  0  234 TYR A CB    1 ? 
ATOM   1829 C CG    . TYR A 1 234 ? 6.577   10.730  -18.187 1.000 15.119  0  234 TYR A CG    1 ? 
ATOM   1830 C CD1   . TYR A 1 234 ? 7.645   11.608  -18.251 1.000 15.883  0  234 TYR A CD1   1 ? 
ATOM   1831 C CD2   . TYR A 1 234 ? 6.858   9.386   -17.995 1.000 15.069  0  234 TYR A CD2   1 ? 
ATOM   1832 C CE1   . TYR A 1 234 ? 8.952   11.180  -18.046 1.000 16.554  0  234 TYR A CE1   1 ? 
ATOM   1833 C CE2   . TYR A 1 234 ? 8.160   8.942   -17.818 1.000 14.120  0  234 TYR A CE2   1 ? 
ATOM   1834 C CZ    . TYR A 1 234 ? 9.219   9.840   -17.861 1.000 16.887  0  234 TYR A CZ    1 ? 
ATOM   1835 O OH    . TYR A 1 234 ? 10.532  9.429   -17.705 1.000 16.528  0  234 TYR A OH    1 ? 
ATOM   1836 N N     . ASP A 1 235 ? 2.799   10.093  -20.355 1.000 13.914  0  235 ASP A N     1 ? 
ATOM   1837 C CA    . ASP A 1 235 ? 1.354   9.901   -20.617 1.000 13.325  0  235 ASP A CA    1 ? 
ATOM   1838 C C     . ASP A 1 235 ? 0.794   8.996   -19.537 1.000 11.440  0  235 ASP A C     1 ? 
ATOM   1839 O O     . ASP A 1 235 ? 0.797   7.777   -19.744 1.000 9.966   0  235 ASP A O     1 ? 
ATOM   1840 C CB    . ASP A 1 235 ? 1.171   9.330   -22.020 1.000 15.215  0  235 ASP A CB    1 ? 
ATOM   1841 C CG    . ASP A 1 235 ? -0.273  9.262   -22.495 1.000 15.829  0  235 ASP A CG    1 ? 
ATOM   1842 O OD1   . ASP A 1 235 ? -1.206  9.391   -21.657 1.000 16.267  0  235 ASP A OD1   1 ? 
ATOM   1843 O OD2   . ASP A 1 235 ? -0.439  9.136   -23.704 1.000 17.018  0  235 ASP A OD2   1 ? 
ATOM   1844 N N     . ASP A 1 236 ? 0.388   9.573   -18.407 1.000 11.214  0  236 ASP A N     1 ? 
ATOM   1845 C CA    . ASP A 1 236 ? -0.133  8.805   -17.258 1.000 11.008  0  236 ASP A CA    1 ? 
ATOM   1846 C C     . ASP A 1 236 ? -1.422  8.083   -17.637 1.000 10.590  0  236 ASP A C     1 ? 
ATOM   1847 O O     . ASP A 1 236 ? -1.633  6.948   -17.133 1.000 9.979   0  236 ASP A O     1 ? 
ATOM   1848 C CB    . ASP A 1 236 ? -0.344  9.696   -16.042 1.000 10.957  0  236 ASP A CB    1 ? 
ATOM   1849 C CG    . ASP A 1 236 ? 0.936   10.239  -15.461 1.000 10.500  0  236 ASP A CG    1 ? 
ATOM   1850 O OD1   . ASP A 1 236 ? 2.019   10.095  -16.106 1.000 9.817   0  236 ASP A OD1   1 ? 
ATOM   1851 O OD2   . ASP A 1 236 ? 0.842   10.777  -14.373 1.000 11.808  0  236 ASP A OD2   1 ? 
ATOM   1852 N N     . ARG A 1 237 ? -2.295  8.695   -18.446 1.000 11.325  0  237 ARG A N     1 ? 
ATOM   1853 C CA    . ARG A 1 237 ? -3.580  8.045   -18.824 1.000 11.021  0  237 ARG A CA    1 ? 
ATOM   1854 C C     . ARG A 1 237 ? -3.269  6.743   -19.559 1.000 11.199  0  237 ARG A C     1 ? 
ATOM   1855 O O     . ARG A 1 237 ? -3.879  5.729   -19.266 1.000 10.976  0  237 ARG A O     1 ? 
ATOM   1856 C CB    . ARG A 1 237 ? -4.440  8.955   -19.697 1.000 11.205  0  237 ARG A CB    1 ? 
ATOM   1857 C CG    . ARG A 1 237 ? -5.846  8.445   -19.933 1.000 11.904  0  237 ARG A CG    1 ? 
ATOM   1858 C CD    . ARG A 1 237 ? -6.392  8.954   -21.275 1.000 12.670  0  237 ARG A CD    1 ? 
ATOM   1859 N NE    . ARG A 1 237 ? -5.497  8.557   -22.340 1.000 14.052  0  237 ARG A NE    1 ? 
ATOM   1860 C CZ    . ARG A 1 237 ? -5.362  7.314   -22.781 1.000 13.968  0  237 ARG A CZ    1 ? 
ATOM   1861 N NH1   . ARG A 1 237 ? -6.172  6.353   -22.364 1.000 13.540  0  237 ARG A NH1   1 ? 
ATOM   1862 N NH2   . ARG A 1 237 ? -4.458  7.046   -23.694 1.000 14.161  0  237 ARG A NH2   1 ? 
ATOM   1863 N N     . ASP A 1 238 ? -2.352  6.781   -20.512 1.000 12.753  0  238 ASP A N     1 ? 
ATOM   1864 C CA    . ASP A 1 238 ? -1.969  5.580   -21.291 1.000 13.337  0  238 ASP A CA    1 ? 
ATOM   1865 C C     . ASP A 1 238 ? -1.243  4.591   -20.367 1.000 11.434  0  238 ASP A C     1 ? 
ATOM   1866 O O     . ASP A 1 238 ? -1.538  3.397   -20.442 1.000 12.148  0  238 ASP A O     1 ? 
ATOM   1867 C CB    . ASP A 1 238 ? -1.163  5.980   -22.533 1.000 13.562  0  238 ASP A CB    1 ? 
ATOM   1868 C CG    . ASP A 1 238 ? -0.724  4.769   -23.334 1.000 15.238  0  238 ASP A CG    1 ? 
ATOM   1869 O OD1   . ASP A 1 238 ? -1.597  4.057   -23.788 1.000 15.891  0  238 ASP A OD1   1 ? 
ATOM   1870 O OD2   . ASP A 1 238 ? 0.500   4.482   -23.372 1.000 15.264  0  238 ASP A OD2   1 ? 
ATOM   1871 N N     . ALA A 1 239 ? -0.321  5.034   -19.514 1.000 11.058  0  239 ALA A N     1 ? 
ATOM   1872 C CA    . ALA A 1 239 ? 0.381   4.111   -18.580 1.000 10.777  0  239 ALA A CA    1 ? 
ATOM   1873 C C     . ALA A 1 239 ? -0.668  3.387   -17.727 1.000 10.527  0  239 ALA A C     1 ? 
ATOM   1874 O O     . ALA A 1 239 ? -0.595  2.159   -17.541 1.000 9.231   0  239 ALA A O     1 ? 
ATOM   1875 C CB    . ALA A 1 239 ? 1.372   4.839   -17.714 1.000 11.736  0  239 ALA A CB    1 ? 
ATOM   1876 N N     . LEU A 1 240 ? -1.637  4.123   -17.210 1.000 12.004  0  240 LEU A N     1 ? 
ATOM   1877 C CA    . LEU A 1 240 ? -2.683  3.523   -16.338 1.000 13.361  0  240 LEU A CA    1 ? 
ATOM   1878 C C     . LEU A 1 240 ? -3.540  2.562   -17.180 1.000 11.279  0  240 LEU A C     1 ? 
ATOM   1879 O O     . LEU A 1 240 ? -3.879  1.493   -16.687 1.000 12.099  0  240 LEU A O     1 ? 
ATOM   1880 C CB    . LEU A 1 240 ? -3.546  4.632   -15.717 1.000 15.426  0  240 LEU A CB    1 ? 
ATOM   1881 C CG    . LEU A 1 240 ? -3.395  4.942   -14.229 1.000 20.367  0  240 LEU A CG    1 ? 
ATOM   1882 C CD1   . LEU A 1 240 ? -4.609  5.734   -13.732 1.000 21.091  0  240 LEU A CD1   1 ? 
ATOM   1883 C CD2   . LEU A 1 240 ? -3.196  3.710   -13.345 1.000 18.602  0  240 LEU A CD2   1 ? 
ATOM   1884 N N     . GLU A 1 241 ? -3.945  2.941   -18.375 1.000 12.450  0  241 GLU A N     1 ? 
ATOM   1885 C CA    . GLU A 1 241 ? -4.752  2.066   -19.260 1.000 13.463  0  241 GLU A CA    1 ? 
ATOM   1886 C C     . GLU A 1 241 ? -4.016  0.735   -19.439 1.000 12.474  0  241 GLU A C     1 ? 
ATOM   1887 O O     . GLU A 1 241 ? -4.622  -0.325  -19.206 1.000 12.344  0  241 GLU A O     1 ? 
ATOM   1888 C CB    . GLU A 1 241 ? -5.038  2.746   -20.592 1.000 14.613  0  241 GLU A CB    1 ? 
ATOM   1889 C CG    . GLU A 1 241 ? -5.931  1.925   -21.495 1.000 16.783  0  241 GLU A CG    1 ? 
ATOM   1890 C CD    . GLU A 1 241 ? -5.999  2.390   -22.942 1.000 19.897  0  241 GLU A CD    1 ? 
ATOM   1891 O OE1   . GLU A 1 241 ? -5.917  3.603   -23.196 1.000 20.867  0  241 GLU A OE1   1 ? 
ATOM   1892 O OE2   . GLU A 1 241 ? -6.098  1.531   -23.809 1.000 21.044  0  241 GLU A OE2   1 ? 
ATOM   1893 N N     . GLN A 1 242 ? -2.750  0.773   -19.798 1.000 12.718  0  242 GLN A N     1 ? 
ATOM   1894 C CA    . GLN A 1 242 ? -1.979  -0.475  -20.073 1.000 14.441  0  242 GLN A CA    1 ? 
ATOM   1895 C C     . GLN A 1 242 ? -1.856  -1.283  -18.777 1.000 13.294  0  242 GLN A C     1 ? 
ATOM   1896 O O     . GLN A 1 242 ? -2.005  -2.520  -18.831 1.000 11.902  0  242 GLN A O     1 ? 
ATOM   1897 C CB    . GLN A 1 242 ? -0.589  -0.189  -20.630 1.000 16.707  0  242 GLN A CB    1 ? 
ATOM   1898 C CG    . GLN A 1 242 ? -0.567  0.438   -22.013 1.000 20.708  0  242 GLN A CG    1 ? 
ATOM   1899 C CD    . GLN A 1 242 ? 0.867   0.528   -22.500 1.000 27.652  0  242 GLN A CD    1 ? 
ATOM   1900 O OE1   . GLN A 1 242 ? 1.650   -0.442  -22.432 1.000 31.090  0  242 GLN A OE1   1 ? 
ATOM   1901 N NE2   . GLN A 1 242 ? 1.261   1.718   -22.937 1.000 34.046  0  242 GLN A NE2   1 ? 
ATOM   1902 N N     . PHE A 1 243 ? -1.561  -0.619  -17.659 1.000 11.594  0  243 PHE A N     1 ? 
ATOM   1903 C CA    . PHE A 1 243 ? -1.431  -1.275  -16.345 1.000 11.652  0  243 PHE A CA    1 ? 
ATOM   1904 C C     . PHE A 1 243 ? -2.777  -1.926  -15.954 1.000 11.256  0  243 PHE A C     1 ? 
ATOM   1905 O O     . PHE A 1 243 ? -2.782  -3.126  -15.526 1.000 10.094  0  243 PHE A O     1 ? 
ATOM   1906 C CB    . PHE A 1 243 ? -0.891  -0.266  -15.321 1.000 11.624  0  243 PHE A CB    1 ? 
ATOM   1907 C CG    . PHE A 1 243 ? -0.776  -0.744  -13.908 1.000 12.289  0  243 PHE A CG    1 ? 
ATOM   1908 C CD1   . PHE A 1 243 ? -0.492  -2.048  -13.618 1.000 11.914  0  243 PHE A CD1   1 ? 
ATOM   1909 C CD2   . PHE A 1 243 ? -0.901  0.162   -12.859 1.000 12.092  0  243 PHE A CD2   1 ? 
ATOM   1910 C CE1   . PHE A 1 243 ? -0.439  -2.467  -12.300 1.000 13.893  0  243 PHE A CE1   1 ? 
ATOM   1911 C CE2   . PHE A 1 243 ? -0.807  -0.250  -11.546 1.000 12.530  0  243 PHE A CE2   1 ? 
ATOM   1912 C CZ    . PHE A 1 243 ? -0.557  -1.557  -11.265 1.000 13.294  0  243 PHE A CZ    1 ? 
ATOM   1913 N N     . VAL A 1 244 ? -3.884  -1.200  -16.055 1.000 10.089  0  244 VAL A N     1 ? 
ATOM   1914 C CA    . VAL A 1 244 ? -5.207  -1.744  -15.624 1.000 10.363  0  244 VAL A CA    1 ? 
ATOM   1915 C C     . VAL A 1 244 ? -5.549  -2.935  -16.548 1.000 10.490  0  244 VAL A C     1 ? 
ATOM   1916 O O     . VAL A 1 244 ? -6.047  -3.993  -16.066 1.000 11.108  0  244 VAL A O     1 ? 
ATOM   1917 C CB    . VAL A 1 244 ? -6.275  -0.645  -15.613 1.000 10.233  0  244 VAL A CB    1 ? 
ATOM   1918 C CG1   . VAL A 1 244 ? -7.684  -1.202  -15.455 1.000 10.938  0  244 VAL A CG1   1 ? 
ATOM   1919 C CG2   . VAL A 1 244 ? -5.972  0.353   -14.495 1.000 10.875  0  244 VAL A CG2   1 ? 
ATOM   1920 N N     . GLN A 1 245 ? -5.348  -2.778  -17.838 1.000 11.473  0  245 GLN A N     1 ? 
ATOM   1921 C CA    . GLN A 1 245 ? -5.666  -3.866  -18.799 1.000 11.584  0  245 GLN A CA    1 ? 
ATOM   1922 C C     . GLN A 1 245 ? -4.834  -5.094  -18.422 1.000 12.092  0  245 GLN A C     1 ? 
ATOM   1923 O O     . GLN A 1 245 ? -5.374  -6.231  -18.492 1.000 11.013  0  245 GLN A O     1 ? 
ATOM   1924 C CB    . GLN A 1 245 ? -5.412  -3.461  -20.250 1.000 13.721  0  245 GLN A CB    1 ? 
ATOM   1925 C CG    . GLN A 1 245 ? -5.755  -4.578  -21.263 1.000 15.142  0  245 GLN A CG    1 ? 
ATOM   1926 C CD    . GLN A 1 245 ? -7.229  -4.895  -21.235 1.000 17.584  0  245 GLN A CD    1 ? 
ATOM   1927 O OE1   . GLN A 1 245 ? -8.023  -4.124  -21.734 1.000 21.677  0  245 GLN A OE1   1 ? 
ATOM   1928 N NE2   . GLN A 1 245 ? -7.625  -5.956  -20.554 1.000 18.898  0  245 GLN A NE2   1 ? 
ATOM   1929 N N     . THR A 1 246 ? -3.554  -4.917  -18.062 1.000 12.283  0  246 THR A N     1 ? 
ATOM   1930 C CA    . THR A 1 246 ? -2.666  -6.059  -17.720 1.000 12.943  0  246 THR A CA    1 ? 
ATOM   1931 C C     . THR A 1 246 ? -3.170  -6.760  -16.456 1.000 13.081  0  246 THR A C     1 ? 
ATOM   1932 O O     . THR A 1 246 ? -3.195  -8.004  -16.423 1.000 11.506  0  246 THR A O     1 ? 
ATOM   1933 C CB    . THR A 1 246 ? -1.185  -5.658  -17.681 1.000 13.430  0  246 THR A CB    1 ? 
ATOM   1934 O OG1   . THR A 1 246 ? -0.852  -5.152  -18.970 1.000 13.271  0  246 THR A OG1   1 ? 
ATOM   1935 C CG2   . THR A 1 246 ? -0.274  -6.836  -17.385 1.000 13.287  0  246 THR A CG2   1 ? 
ATOM   1936 N N     . MET A 1 247 ? -3.591  -6.010  -15.444 1.000 12.404  0  247 MET A N     1 ? 
ATOM   1937 C CA    . MET A 1 247 ? -4.205  -6.586  -14.229 1.000 12.598  0  247 MET A CA    1 ? 
ATOM   1938 C C     . MET A 1 247 ? -5.446  -7.399  -14.610 1.000 11.210  0  247 MET A C     1 ? 
ATOM   1939 O O     . MET A 1 247 ? -5.570  -8.530  -14.137 1.000 12.078  0  247 MET A O     1 ? 
ATOM   1940 C CB    . MET A 1 247 ? -4.593  -5.474  -13.244 1.000 13.686  0  247 MET A CB    1 ? 
ATOM   1941 C CG    . MET A 1 247 ? -3.389  -4.870  -12.548 1.000 16.097  0  247 MET A CG    1 ? 
ATOM   1942 S SD    . MET A 1 247 ? -3.875  -3.577  -11.350 1.000 19.537  0  247 MET A SD    1 ? 
ATOM   1943 C CE    . MET A 1 247 ? -4.692  -4.618  -10.163 1.000 20.652  0  247 MET A CE    1 ? 
ATOM   1944 N N     . LEU A 1 248 ? -6.342  -6.836  -15.397 1.000 11.088  0  248 LEU A N     1 ? 
ATOM   1945 C CA    . LEU A 1 248 ? -7.590  -7.517  -15.813 1.000 12.195  0  248 LEU A CA    1 ? 
ATOM   1946 C C     . LEU A 1 248 ? -7.207  -8.816  -16.529 1.000 14.412  0  248 LEU A C     1 ? 
ATOM   1947 O O     . LEU A 1 248 ? -7.847  -9.847  -16.253 1.000 13.940  0  248 LEU A O     1 ? 
ATOM   1948 C CB    . LEU A 1 248 ? -8.406  -6.605  -16.723 1.000 11.684  0  248 LEU A CB    1 ? 
ATOM   1949 C CG    . LEU A 1 248 ? -9.176  -5.503  -15.992 1.000 12.461  0  248 LEU A CG    1 ? 
ATOM   1950 C CD1   . LEU A 1 248 ? -9.634  -4.426  -16.957 1.000 12.640  0  248 LEU A CD1   1 ? 
ATOM   1951 C CD2   . LEU A 1 248 ? -10.362 -6.106  -15.253 1.000 12.823  0  248 LEU A CD2   1 ? 
ATOM   1952 N N     . ASP A 1 249 ? -6.156  -8.773  -17.352 1.000 15.768  0  249 ASP A N     1 ? 
ATOM   1953 C CA    . ASP A 1 249 ? -5.710  -9.952  -18.145 1.000 17.518  0  249 ASP A CA    1 ? 
ATOM   1954 C C     . ASP A 1 249 ? -5.196  -11.053 -17.219 1.000 17.214  0  249 ASP A C     1 ? 
ATOM   1955 O O     . ASP A 1 249 ? -5.079  -12.201 -17.674 1.000 18.391  0  249 ASP A O     1 ? 
ATOM   1956 C CB    . ASP A 1 249 ? -4.602  -9.557  -19.115 1.000 18.536  0  249 ASP A CB    1 ? 
ATOM   1957 C CG    . ASP A 1 249 ? -5.084  -8.778  -20.307 1.000 19.308  0  249 ASP A CG    1 ? 
ATOM   1958 O OD1   . ASP A 1 249 ? -6.316  -8.668  -20.500 1.000 19.560  0  249 ASP A OD1   1 ? 
ATOM   1959 O OD2   . ASP A 1 249 ? -4.220  -8.273  -21.008 1.000 23.695  0  249 ASP A OD2   1 ? 
ATOM   1960 N N     . ASN A 1 250 ? -4.849  -10.731 -15.978 1.000 14.516  0  250 ASN A N     1 ? 
ATOM   1961 C CA    . ASN A 1 250 ? -4.312  -11.717 -15.014 1.000 14.678  0  250 ASN A CA    1 ? 
ATOM   1962 C C     . ASN A 1 250 ? -5.383  -12.250 -14.038 1.000 13.336  0  250 ASN A C     1 ? 
ATOM   1963 O O     . ASN A 1 250 ? -5.020  -12.999 -13.134 1.000 14.396  0  250 ASN A O     1 ? 
ATOM   1964 C CB    . ASN A 1 250 ? -3.110  -11.117 -14.308 1.000 14.709  0  250 ASN A CB    1 ? 
ATOM   1965 C CG    . ASN A 1 250 ? -1.884  -11.226 -15.177 1.000 17.272  0  250 ASN A CG    1 ? 
ATOM   1966 O OD1   . ASN A 1 250 ? -1.242  -12.293 -15.188 1.000 18.871  0  250 ASN A OD1   1 ? 
ATOM   1967 N ND2   . ASN A 1 250 ? -1.584  -10.179 -15.939 1.000 18.286  0  250 ASN A ND2   1 ? 
ATOM   1968 N N     . PHE A 1 251 ? -6.645  -11.843 -14.156 1.000 13.199  0  251 PHE A N     1 ? 
ATOM   1969 C CA    . PHE A 1 251 ? -7.744  -12.482 -13.412 1.000 13.200  0  251 PHE A CA    1 ? 
ATOM   1970 C C     . PHE A 1 251 ? -7.961  -13.852 -14.067 1.000 16.274  0  251 PHE A C     1 ? 
ATOM   1971 O O     . PHE A 1 251 ? -7.811  -13.946 -15.308 1.000 15.897  0  251 PHE A O     1 ? 
ATOM   1972 C CB    . PHE A 1 251 ? -9.026  -11.666 -13.408 1.000 12.932  0  251 PHE A CB    1 ? 
ATOM   1973 C CG    . PHE A 1 251 ? -9.061  -10.526 -12.408 1.000 13.076  0  251 PHE A CG    1 ? 
ATOM   1974 C CD1   . PHE A 1 251 ? -8.381  -9.343  -12.656 1.000 13.606  0  251 PHE A CD1   1 ? 
ATOM   1975 C CD2   . PHE A 1 251 ? -9.789  -10.633 -11.234 1.000 12.541  0  251 PHE A CD2   1 ? 
ATOM   1976 C CE1   . PHE A 1 251 ? -8.457  -8.263  -11.762 1.000 13.585  0  251 PHE A CE1   1 ? 
ATOM   1977 C CE2   . PHE A 1 251 ? -9.856  -9.572  -10.336 1.000 14.294  0  251 PHE A CE2   1 ? 
ATOM   1978 C CZ    . PHE A 1 251 ? -9.206  -8.383  -10.604 1.000 13.782  0  251 PHE A CZ    1 ? 
ATOM   1979 N N     . HIS A 1 252 ? -8.178  -14.875 -13.251 1.000 14.710  0  252 HIS A N     1 ? 
ATOM   1980 C CA    . HIS A 1 252 ? -8.503  -16.251 -13.694 1.000 15.720  0  252 HIS A CA    1 ? 
ATOM   1981 C C     . HIS A 1 252 ? -9.770  -16.703 -12.997 1.000 14.720  0  252 HIS A C     1 ? 
ATOM   1982 O O     . HIS A 1 252 ? -9.829  -16.615 -11.759 1.000 13.220  0  252 HIS A O     1 ? 
ATOM   1983 C CB    . HIS A 1 252 ? -7.375  -17.213 -13.374 1.000 16.743  0  252 HIS A CB    1 ? 
ATOM   1984 C CG    . HIS A 1 252 ? -6.103  -16.785 -14.018 1.000 19.459  0  252 HIS A CG    1 ? 
ATOM   1985 N ND1   . HIS A 1 252 ? -5.042  -16.321 -13.290 1.000 21.314  0  252 HIS A ND1   1 ? 
ATOM   1986 C CD2   . HIS A 1 252 ? -5.779  -16.603 -15.308 1.000 20.335  0  252 HIS A CD2   1 ? 
ATOM   1987 C CE1   . HIS A 1 252 ? -4.072  -15.970 -14.115 1.000 20.173  0  252 HIS A CE1   1 ? 
ATOM   1988 N NE2   . HIS A 1 252 ? -4.507  -16.106 -15.342 1.000 21.064  0  252 HIS A NE2   1 ? 
ATOM   1989 N N     . ASP A 1 253 ? -10.711 -17.189 -13.774 1.000 15.613  0  253 ASP A N     1 ? 
ATOM   1990 C CA    . ASP A 1 253 ? -11.895 -17.923 -13.248 1.000 17.205  0  253 ASP A CA    1 ? 
ATOM   1991 C C     . ASP A 1 253 ? -11.419 -19.089 -12.390 1.000 15.867  0  253 ASP A C     1 ? 
ATOM   1992 O O     . ASP A 1 253 ? -10.566 -19.902 -12.837 1.000 17.081  0  253 ASP A O     1 ? 
ATOM   1993 C CB    . ASP A 1 253 ? -12.822 -18.351 -14.379 1.000 19.430  0  253 ASP A CB    1 ? 
ATOM   1994 C CG    . ASP A 1 253 ? -13.472 -17.183 -15.092 1.000 23.466  0  253 ASP A CG    1 ? 
ATOM   1995 O OD1   . ASP A 1 253 ? -13.567 -16.068 -14.498 1.000 25.296  0  253 ASP A OD1   1 ? 
ATOM   1996 O OD2   . ASP A 1 253 ? -13.870 -17.392 -16.227 1.000 30.938  0  253 ASP A OD2   1 ? 
ATOM   1997 N N     . THR A 1 254 ? -11.912 -19.145 -11.172 1.000 14.758  0  254 THR A N     1 ? 
ATOM   1998 C CA    . THR A 1 254 ? -11.465 -20.088 -10.130 1.000 14.430  0  254 THR A CA    1 ? 
ATOM   1999 C C     . THR A 1 254 ? -12.701 -20.783 -9.573  1.000 14.586  0  254 THR A C     1 ? 
ATOM   2000 O O     . THR A 1 254 ? -13.534 -20.114 -8.940  1.000 12.033  0  254 THR A O     1 ? 
ATOM   2001 C CB    . THR A 1 254 ? -10.712 -19.358 -9.015  1.000 15.222  0  254 THR A CB    1 ? 
ATOM   2002 O OG1   . THR A 1 254 ? -9.635  -18.627 -9.621  1.000 16.370  0  254 THR A OG1   1 ? 
ATOM   2003 C CG2   . THR A 1 254 ? -10.172 -20.286 -7.952  1.000 15.033  0  254 THR A CG2   1 ? 
ATOM   2004 N N     . TRP A 1 255 ? -12.771 -22.097 -9.717  1.000 12.461  0  255 TRP A N     1 ? 
ATOM   2005 C CA    . TRP A 1 255 ? -13.913 -22.907 -9.250  1.000 13.665  0  255 TRP A CA    1 ? 
ATOM   2006 C C     . TRP A 1 255 ? -14.011 -22.864 -7.717  1.000 14.188  0  255 TRP A C     1 ? 
ATOM   2007 O O     . TRP A 1 255 ? -12.975 -22.969 -7.006  1.000 15.984  0  255 TRP A O     1 ? 
ATOM   2008 C CB    . TRP A 1 255 ? -13.743 -24.338 -9.772  1.000 13.939  0  255 TRP A CB    1 ? 
ATOM   2009 C CG    . TRP A 1 255 ? -14.858 -25.253 -9.381  1.000 14.594  0  255 TRP A CG    1 ? 
ATOM   2010 C CD1   . TRP A 1 255 ? -14.821 -26.291 -8.507  1.000 16.771  0  255 TRP A CD1   1 ? 
ATOM   2011 C CD2   . TRP A 1 255 ? -16.180 -25.247 -9.927  1.000 15.670  0  255 TRP A CD2   1 ? 
ATOM   2012 N NE1   . TRP A 1 255 ? -16.045 -26.921 -8.465  1.000 15.869  0  255 TRP A NE1   1 ? 
ATOM   2013 C CE2   . TRP A 1 255 ? -16.883 -26.320 -9.348  1.000 15.554  0  255 TRP A CE2   1 ? 
ATOM   2014 C CE3   . TRP A 1 255 ? -16.831 -24.445 -10.867 1.000 16.038  0  255 TRP A CE3   1 ? 
ATOM   2015 C CZ2   . TRP A 1 255 ? -18.221 -26.575 -9.639  1.000 17.505  0  255 TRP A CZ2   1 ? 
ATOM   2016 C CZ3   . TRP A 1 255 ? -18.134 -24.730 -11.187 1.000 16.498  0  255 TRP A CZ3   1 ? 
ATOM   2017 C CH2   . TRP A 1 255 ? -18.827 -25.772 -10.571 1.000 17.656  0  255 TRP A CH2   1 ? 
ATOM   2018 N N     . ASP A 1 256 ? -15.211 -22.739 -7.210  1.000 14.877  0  256 ASP A N     1 ? 
ATOM   2019 C CA    . ASP A 1 256 ? -15.506 -22.824 -5.760  1.000 17.188  0  256 ASP A CA    1 ? 
ATOM   2020 C C     . ASP A 1 256 ? -16.492 -23.979 -5.554  1.000 15.284  0  256 ASP A C     1 ? 
ATOM   2021 O O     . ASP A 1 256 ? -17.638 -23.864 -6.021  1.000 17.297  0  256 ASP A O     1 ? 
ATOM   2022 C CB    . ASP A 1 256 ? -16.083 -21.510 -5.226  1.000 18.721  0  256 ASP A CB    1 ? 
ATOM   2023 C CG    . ASP A 1 256 ? -16.339 -21.575 -3.745  1.000 22.410  0  256 ASP A CG    1 ? 
ATOM   2024 O OD1   . ASP A 1 256 ? -17.502 -21.808 -3.359  1.000 26.465  0  256 ASP A OD1   1 ? 
ATOM   2025 O OD2   . ASP A 1 256 ? -15.359 -21.530 -3.002  1.000 28.135  0  256 ASP A OD2   1 ? 
ATOM   2026 N N     . SER A 1 257 ? -16.066 -25.057 -4.912  1.000 16.453  0  257 SER A N     1 ? 
ATOM   2027 C CA    . SER A 1 257 ? -16.892 -26.296 -4.776  1.000 18.489  0  257 SER A CA    1 ? 
ATOM   2028 C C     . SER A 1 257 ? -18.148 -26.014 -3.935  1.000 20.633  0  257 SER A C     1 ? 
ATOM   2029 O O     . SER A 1 257 ? -19.189 -26.607 -4.228  1.000 22.443  0  257 SER A O     1 ? 
ATOM   2030 C CB    . SER A 1 257 ? -16.120 -27.410 -4.173  1.000 17.131  0  257 SER A CB    1 ? 
ATOM   2031 O OG    . SER A 1 257 ? -15.564 -27.022 -2.927  1.000 19.228  0  257 SER A OG    1 ? 
ATOM   2032 N N     . LYS A 1 258 ? -18.065 -25.145 -2.934  1.000 23.503  0  258 LYS A N     1 ? 
ATOM   2033 C CA    . LYS A 1 258 ? -19.233 -24.842 -2.056  1.000 27.297  0  258 LYS A CA    1 ? 
ATOM   2034 C C     . LYS A 1 258 ? -20.329 -24.179 -2.894  1.000 25.198  0  258 LYS A C     1 ? 
ATOM   2035 O O     . LYS A 1 258 ? -21.497 -24.654 -2.872  1.000 22.967  0  258 LYS A O     1 ? 
ATOM   2036 C CB    . LYS A 1 258 ? -18.824 -23.950 -0.880  1.000 33.670  0  258 LYS A CB    1 ? 
ATOM   2037 C CG    . LYS A 1 258 ? -19.849 -23.891 0.249   1.000 42.359  0  258 LYS A CG    1 ? 
ATOM   2038 C CD    . LYS A 1 258 ? -20.007 -25.209 0.990   1.000 47.960  0  258 LYS A CD    1 ? 
ATOM   2039 C CE    . LYS A 1 258 ? -18.684 -25.919 1.216   1.000 50.856  0  258 LYS A CE    1 ? 
ATOM   2040 N NZ    . LYS A 1 258 ? -18.804 -27.006 2.214   1.000 57.684  0  258 LYS A NZ    1 ? 
ATOM   2041 N N     . ASP A 1 259 ? -19.978 -23.138 -3.633  1.000 20.690  0  259 ASP A N     1 ? 
ATOM   2042 C CA    . ASP A 1 259 ? -20.958 -22.304 -4.350  1.000 21.873  0  259 ASP A CA    1 ? 
ATOM   2043 C C     . ASP A 1 259 ? -21.266 -22.917 -5.702  1.000 20.783  0  259 ASP A C     1 ? 
ATOM   2044 O O     . ASP A 1 259 ? -22.216 -22.464 -6.344  1.000 19.224  0  259 ASP A O     1 ? 
ATOM   2045 C CB    . ASP A 1 259 ? -20.470 -20.870 -4.490  1.000 22.338  0  259 ASP A CB    1 ? 
ATOM   2046 C CG    . ASP A 1 259 ? -20.405 -20.135 -3.170  1.000 25.675  0  259 ASP A CG    1 ? 
ATOM   2047 O OD1   . ASP A 1 259 ? -20.618 -20.795 -2.114  1.000 27.303  0  259 ASP A OD1   1 ? 
ATOM   2048 O OD2   . ASP A 1 259 ? -20.100 -18.914 -3.202  1.000 25.898  0  259 ASP A OD2   1 ? 
ATOM   2049 N N     . GLN A 1 260 ? -20.478 -23.896 -6.138  1.000 19.921  0  260 GLN A N     1 ? 
ATOM   2050 C CA    . GLN A 1 260 ? -20.735 -24.607 -7.414  1.000 20.438  0  260 GLN A CA    1 ? 
ATOM   2051 C C     . GLN A 1 260 ? -20.724 -23.610 -8.551  1.000 16.506  0  260 GLN A C     1 ? 
ATOM   2052 O O     . GLN A 1 260 ? -21.595 -23.684 -9.424  1.000 15.312  0  260 GLN A O     1 ? 
ATOM   2053 C CB    . GLN A 1 260 ? -22.075 -25.348 -7.349  1.000 23.337  0  260 GLN A CB    1 ? 
ATOM   2054 C CG    . GLN A 1 260 ? -21.984 -26.611 -6.528  1.000 24.932  0  260 GLN A CG    1 ? 
ATOM   2055 C CD    . GLN A 1 260 ? -21.116 -27.624 -7.230  1.000 25.138  0  260 GLN A CD    1 ? 
ATOM   2056 O OE1   . GLN A 1 260 ? -21.472 -28.144 -8.290  1.000 25.788  0  260 GLN A OE1   1 ? 
ATOM   2057 N NE2   . GLN A 1 260 ? -19.954 -27.898 -6.651  1.000 25.572  0  260 GLN A NE2   1 ? 
ATOM   2058 N N     . ARG A 1 261 ? -19.781 -22.668 -8.513  1.000 15.136  0  261 ARG A N     1 ? 
ATOM   2059 C CA    . ARG A 1 261 ? -19.554 -21.720 -9.606  1.000 15.457  0  261 ARG A CA    1 ? 
ATOM   2060 C C     . ARG A 1 261 ? -18.095 -21.268 -9.579  1.000 15.167  0  261 ARG A C     1 ? 
ATOM   2061 O O     . ARG A 1 261 ? -17.393 -21.606 -8.643  1.000 13.729  0  261 ARG A O     1 ? 
ATOM   2062 C CB    . ARG A 1 261 ? -20.508 -20.526 -9.449  1.000 15.394  0  261 ARG A CB    1 ? 
ATOM   2063 C CG    . ARG A 1 261 ? -20.281 -19.720 -8.181  1.000 16.031  0  261 ARG A CG    1 ? 
ATOM   2064 C CD    . ARG A 1 261 ? -20.962 -18.348 -8.292  1.000 17.905  0  261 ARG A CD    1 ? 
ATOM   2065 N NE    . ARG A 1 261 ? -20.159 -17.465 -9.120  1.000 20.565  0  261 ARG A NE    1 ? 
ATOM   2066 C CZ    . ARG A 1 261 ? -20.450 -16.191 -9.404  1.000 23.684  0  261 ARG A CZ    1 ? 
ATOM   2067 N NH1   . ARG A 1 261 ? -21.554 -15.637 -8.928  1.000 22.995  0  261 ARG A NH1   1 ? 
ATOM   2068 N NH2   . ARG A 1 261 ? -19.609 -15.477 -10.125 1.000 22.569  0  261 ARG A NH2   1 ? 
ATOM   2069 N N     . SER A 1 262 ? -17.695 -20.478 -10.569 1.000 15.854  0  262 SER A N     1 ? 
ATOM   2070 C CA    . SER A 1 262 ? -16.352 -19.867 -10.622 1.000 16.798  0  262 SER A CA    1 ? 
ATOM   2071 C C     . SER A 1 262 ? -16.449 -18.408 -10.174 1.000 15.287  0  262 SER A C     1 ? 
ATOM   2072 O O     . SER A 1 262 ? -17.531 -17.793 -10.310 1.000 13.717  0  262 SER A O     1 ? 
ATOM   2073 C CB    . SER A 1 262 ? -15.764 -20.013 -11.975 1.000 16.624  0  262 SER A CB    1 ? 
ATOM   2074 O OG    . SER A 1 262 ? -15.465 -21.394 -12.209 1.000 20.651  0  262 SER A OG    1 ? 
ATOM   2075 N N     . TYR A 1 263 ? -15.378 -17.909 -9.597  1.000 14.092  0  263 TYR A N     1 ? 
ATOM   2076 C CA    . TYR A 1 263 ? -15.180 -16.462 -9.362  1.000 13.937  0  263 TYR A CA    1 ? 
ATOM   2077 C C     . TYR A 1 263 ? -13.891 -16.088 -10.062 1.000 15.721  0  263 TYR A C     1 ? 
ATOM   2078 O O     . TYR A 1 263 ? -12.923 -16.837 -10.011 1.000 14.206  0  263 TYR A O     1 ? 
ATOM   2079 C CB    . TYR A 1 263 ? -15.117 -16.145 -7.867  1.000 14.613  0  263 TYR A CB    1 ? 
ATOM   2080 C CG    . TYR A 1 263 ? -16.385 -16.463 -7.116  1.000 15.499  0  263 TYR A CG    1 ? 
ATOM   2081 C CD1   . TYR A 1 263 ? -17.466 -15.600 -7.144  1.000 17.645  0  263 TYR A CD1   1 ? 
ATOM   2082 C CD2   . TYR A 1 263 ? -16.520 -17.650 -6.399  1.000 16.741  0  263 TYR A CD2   1 ? 
ATOM   2083 C CE1   . TYR A 1 263 ? -18.617 -15.859 -6.411  1.000 17.905  0  263 TYR A CE1   1 ? 
ATOM   2084 C CE2   . TYR A 1 263 ? -17.673 -17.938 -5.685  1.000 17.484  0  263 TYR A CE2   1 ? 
ATOM   2085 C CZ    . TYR A 1 263 ? -18.737 -17.046 -5.719  1.000 19.728  0  263 TYR A CZ    1 ? 
ATOM   2086 O OH    . TYR A 1 263 ? -19.902 -17.321 -5.058  1.000 21.251  0  263 TYR A OH    1 ? 
ATOM   2087 N N     . PRO A 1 264 ? -13.805 -14.873 -10.614 1.000 16.439  0  264 PRO A N     1 ? 
ATOM   2088 C CA    . PRO A 1 264 ? -12.549 -14.389 -11.182 1.000 16.490  0  264 PRO A CA    1 ? 
ATOM   2089 C C     . PRO A 1 264 ? -11.555 -13.995 -10.071 1.000 17.150  0  264 PRO A C     1 ? 
ATOM   2090 O O     . PRO A 1 264 ? -11.941 -13.225 -9.218  1.000 21.787  0  264 PRO A O     1 ? 
ATOM   2091 C CB    . PRO A 1 264 ? -13.066 -13.196 -12.017 1.000 16.987  0  264 PRO A CB    1 ? 
ATOM   2092 C CG    . PRO A 1 264 ? -14.254 -12.668 -11.261 1.000 17.294  0  264 PRO A CG    1 ? 
ATOM   2093 C CD    . PRO A 1 264 ? -14.849 -13.841 -10.528 1.000 17.324  0  264 PRO A CD    1 ? 
ATOM   2094 N N     . ARG A 1 265 ? -10.320 -14.500 -10.060 1.000 13.889  0  265 ARG A N     1 ? 
ATOM   2095 C CA    . ARG A 1 265 ? -9.378  -14.175 -8.971  1.000 14.016  0  265 ARG A CA    1 ? 
ATOM   2096 C C     . ARG A 1 265 ? -8.100  -13.587 -9.566  1.000 13.854  0  265 ARG A C     1 ? 
ATOM   2097 O O     . ARG A 1 265 ? -7.556  -14.188 -10.541 1.000 12.551  0  265 ARG A O     1 ? 
ATOM   2098 C CB    . ARG A 1 265 ? -9.016  -15.380 -8.107  1.000 15.338  0  265 ARG A CB    1 ? 
ATOM   2099 C CG    . ARG A 1 265 ? -10.143 -15.868 -7.204  1.000 17.070  0  265 ARG A CG    1 ? 
ATOM   2100 C CD    . ARG A 1 265 ? -9.659  -16.712 -6.033  1.000 17.575  0  265 ARG A CD    1 ? 
ATOM   2101 N NE    . ARG A 1 265 ? -8.894  -15.881 -5.135  1.000 16.577  0  265 ARG A NE    1 ? 
ATOM   2102 C CZ    . ARG A 1 265 ? -9.383  -15.199 -4.129  1.000 16.194  0  265 ARG A CZ    1 ? 
ATOM   2103 N NH1   . ARG A 1 265 ? -10.654 -15.308 -3.783  1.000 16.504  0  265 ARG A NH1   1 ? 
ATOM   2104 N NH2   . ARG A 1 265 ? -8.582  -14.399 -3.452  1.000 17.042  0  265 ARG A NH2   1 ? 
ATOM   2105 N N     . LEU A 1 266 ? -7.646  -12.482 -8.975  1.000 11.873  0  266 LEU A N     1 ? 
ATOM   2106 C CA    . LEU A 1 266 ? -6.311  -11.913 -9.250  1.000 12.568  0  266 LEU A CA    1 ? 
ATOM   2107 C C     . LEU A 1 266 ? -5.367  -12.331 -8.128  1.000 12.439  0  266 LEU A C     1 ? 
ATOM   2108 O O     . LEU A 1 266 ? -5.641  -12.030 -6.953  1.000 14.173  0  266 LEU A O     1 ? 
ATOM   2109 C CB    . LEU A 1 266 ? -6.413  -10.384 -9.379  1.000 12.084  0  266 LEU A CB    1 ? 
ATOM   2110 C CG    . LEU A 1 266 ? -5.094  -9.700  -9.693  1.000 12.078  0  266 LEU A CG    1 ? 
ATOM   2111 C CD1   . LEU A 1 266 ? -4.586  -10.137 -11.051 1.000 12.495  0  266 LEU A CD1   1 ? 
ATOM   2112 C CD2   . LEU A 1 266 ? -5.259  -8.169  -9.626  1.000 12.156  0  266 LEU A CD2   1 ? 
ATOM   2113 N N     . THR A 1 267 ? -4.344  -13.102 -8.476  1.000 12.813  0  267 THR A N     1 ? 
ATOM   2114 C CA    . THR A 1 267 ? -3.268  -13.541 -7.566  1.000 14.436  0  267 THR A CA    1 ? 
ATOM   2115 C C     . THR A 1 267 ? -2.060  -12.601 -7.740  1.000 15.832  0  267 THR A C     1 ? 
ATOM   2116 O O     . THR A 1 267 ? -1.600  -12.417 -8.876  1.000 16.459  0  267 THR A O     1 ? 
ATOM   2117 C CB    . THR A 1 267 ? -2.890  -15.008 -7.830  1.000 16.828  0  267 THR A CB    1 ? 
ATOM   2118 O OG1   . THR A 1 267 ? -4.054  -15.797 -7.583  1.000 17.903  0  267 THR A OG1   1 ? 
ATOM   2119 C CG2   . THR A 1 267 ? -1.798  -15.492 -6.904  1.000 18.372  0  267 THR A CG2   1 ? 
ATOM   2120 N N     . VAL A 1 268 ? -1.628  -11.953 -6.676  1.000 16.258  0  268 VAL A N     1 ? 
ATOM   2121 C CA    . VAL A 1 268 ? -0.447  -11.049 -6.741  1.000 16.865  0  268 VAL A CA    1 ? 
ATOM   2122 C C     . VAL A 1 268 ? 0.521   -11.514 -5.667  1.000 16.614  0  268 VAL A C     1 ? 
ATOM   2123 O O     . VAL A 1 268 ? 0.322   -11.150 -4.510  1.000 15.545  0  268 VAL A O     1 ? 
ATOM   2124 C CB    . VAL A 1 268 ? -0.830  -9.569  -6.572  1.000 17.164  0  268 VAL A CB    1 ? 
ATOM   2125 C CG1   . VAL A 1 268 ? 0.395   -8.666  -6.669  1.000 18.317  0  268 VAL A CG1   1 ? 
ATOM   2126 C CG2   . VAL A 1 268 ? -1.882  -9.116  -7.564  1.000 18.762  0  268 VAL A CG2   1 ? 
ATOM   2127 N N     . GLU A 1 269 ? 1.544   -12.261 -6.062  1.000 18.357  0  269 GLU A N     1 ? 
ATOM   2128 C CA    . GLU A 1 269 ? 2.582   -12.759 -5.131  1.000 19.918  0  269 GLU A CA    1 ? 
ATOM   2129 C C     . GLU A 1 269 ? 3.485   -11.597 -4.764  1.000 17.789  0  269 GLU A C     1 ? 
ATOM   2130 O O     . GLU A 1 269 ? 3.817   -10.799 -5.651  1.000 14.563  0  269 GLU A O     1 ? 
ATOM   2131 C CB    . GLU A 1 269 ? 3.390   -13.876 -5.774  1.000 23.639  0  269 GLU A CB    1 ? 
ATOM   2132 C CG    . GLU A 1 269 ? 2.564   -15.097 -6.053  1.000 28.639  0  269 GLU A CG    1 ? 
ATOM   2133 C CD    . GLU A 1 269 ? 3.410   -16.323 -6.327  1.000 32.616  0  269 GLU A CD    1 ? 
ATOM   2134 O OE1   . GLU A 1 269 ? 4.650   -16.170 -6.473  1.000 36.849  0  269 GLU A OE1   1 ? 
ATOM   2135 O OE2   . GLU A 1 269 ? 2.835   -17.414 -6.360  1.000 42.172  0  269 GLU A OE2   1 ? 
ATOM   2136 N N     . LEU A 1 270 ? 3.815   -11.488 -3.492  1.000 16.391  0  270 LEU A N     1 ? 
ATOM   2137 C CA    . LEU A 1 270 ? 4.906   -10.608 -3.033  1.000 16.738  0  270 LEU A CA    1 ? 
ATOM   2138 C C     . LEU A 1 270 ? 6.180   -11.064 -3.726  1.000 14.382  0  270 LEU A C     1 ? 
ATOM   2139 O O     . LEU A 1 270 ? 6.389   -12.258 -3.860  1.000 12.141  0  270 LEU A O     1 ? 
ATOM   2140 C CB    . LEU A 1 270 ? 4.987   -10.755 -1.521  1.000 19.291  0  270 LEU A CB    1 ? 
ATOM   2141 C CG    . LEU A 1 270 ? 5.442   -9.524  -0.763  1.000 22.605  0  270 LEU A CG    1 ? 
ATOM   2142 C CD1   . LEU A 1 270 ? 4.504   -8.344  -0.991  1.000 21.138  0  270 LEU A CD1   1 ? 
ATOM   2143 C CD2   . LEU A 1 270 ? 5.540   -9.848  0.723   1.000 22.769  0  270 LEU A CD2   1 ? 
ATOM   2144 N N     . PRO A 1 271 ? 7.034   -10.162 -4.261  1.000 15.393  0  271 PRO A N     1 ? 
ATOM   2145 C CA    . PRO A 1 271 ? 8.246   -10.608 -4.949  1.000 15.367  0  271 PRO A CA    1 ? 
ATOM   2146 C C     . PRO A 1 271 ? 9.393   -10.940 -3.992  1.000 17.097  0  271 PRO A C     1 ? 
ATOM   2147 O O     . PRO A 1 271 ? 10.519  -11.126 -4.483  1.000 16.699  0  271 PRO A O     1 ? 
ATOM   2148 C CB    . PRO A 1 271 ? 8.586   -9.407  -5.832  1.000 15.168  0  271 PRO A CB    1 ? 
ATOM   2149 C CG    . PRO A 1 271 ? 8.147   -8.238  -4.975  1.000 15.746  0  271 PRO A CG    1 ? 
ATOM   2150 C CD    . PRO A 1 271 ? 6.846   -8.694  -4.326  1.000 15.282  0  271 PRO A CD    1 ? 
ATOM   2151 N N     . VAL A 1 272 ? 9.144   -10.903 -2.676  1.000 15.556  0  272 VAL A N     1 ? 
ATOM   2152 C CA    . VAL A 1 272 ? 10.138  -11.256 -1.621  1.000 15.701  0  272 VAL A CA    1 ? 
ATOM   2153 C C     . VAL A 1 272 ? 9.456   -12.228 -0.657  1.000 16.045  0  272 VAL A C     1 ? 
ATOM   2154 O O     . VAL A 1 272 ? 8.214   -12.389 -0.735  1.000 14.438  0  272 VAL A O     1 ? 
ATOM   2155 C CB    . VAL A 1 272 ? 10.686  -9.995  -0.896  1.000 15.747  0  272 VAL A CB    1 ? 
ATOM   2156 C CG1   . VAL A 1 272 ? 11.432  -9.108  -1.869  1.000 18.171  0  272 VAL A CG1   1 ? 
ATOM   2157 C CG2   . VAL A 1 272 ? 9.604   -9.191  -0.163  1.000 15.911  0  272 VAL A CG2   1 ? 
ATOM   2158 N N     . GLN A 1 273 ? 10.214  -12.842 0.249   1.000 16.259  0  273 GLN A N     1 ? 
ATOM   2159 C CA    . GLN A 1 273 ? 9.631   -13.681 1.324   1.000 16.678  0  273 GLN A CA    1 ? 
ATOM   2160 C C     . GLN A 1 273 ? 8.535   -12.897 2.022   1.000 15.633  0  273 GLN A C     1 ? 
ATOM   2161 O O     . GLN A 1 273 ? 8.703   -11.735 2.343   1.000 16.065  0  273 GLN A O     1 ? 
ATOM   2162 C CB    . GLN A 1 273 ? 10.711  -14.074 2.328   1.000 19.492  0  273 GLN A CB    1 ? 
ATOM   2163 C CG    . GLN A 1 273 ? 11.712  -15.023 1.738   1.000 20.646  0  273 GLN A CG    1 ? 
ATOM   2164 C CD    . GLN A 1 273 ? 11.173  -16.430 1.774   1.000 24.810  0  273 GLN A CD    1 ? 
ATOM   2165 O OE1   . GLN A 1 273 ? 10.003  -16.663 2.064   1.000 23.711  0  273 GLN A OE1   1 ? 
ATOM   2166 N NE2   . GLN A 1 273 ? 12.031  -17.385 1.459   1.000 25.718  0  273 GLN A NE2   1 ? 
ATOM   2167 N N     . PRO A 1 274 ? 7.395   -13.517 2.352   1.000 17.628  0  274 PRO A N     1 ? 
ATOM   2168 C CA    . PRO A 1 274 ? 7.182   -14.940 2.114   1.000 18.875  0  274 PRO A CA    1 ? 
ATOM   2169 C C     . PRO A 1 274 ? 6.506   -15.342 0.796   1.000 20.294  0  274 PRO A C     1 ? 
ATOM   2170 O O     . PRO A 1 274 ? 6.000   -16.471 0.725   1.000 20.538  0  274 PRO A O     1 ? 
ATOM   2171 C CB    . PRO A 1 274 ? 6.265   -15.285 3.291   1.000 19.785  0  274 PRO A CB    1 ? 
ATOM   2172 C CG    . PRO A 1 274 ? 5.432   -14.068 3.496   1.000 19.399  0  274 PRO A CG    1 ? 
ATOM   2173 C CD    . PRO A 1 274 ? 6.339   -12.905 3.157   1.000 18.837  0  274 PRO A CD    1 ? 
ATOM   2174 N N     . TYR A 1 275 ? 6.483   -14.450 -0.204  1.000 16.523  0  275 TYR A N     1 ? 
ATOM   2175 C CA    . TYR A 1 275 ? 6.001   -14.737 -1.583  1.000 17.284  0  275 TYR A CA    1 ? 
ATOM   2176 C C     . TYR A 1 275 ? 4.510   -15.125 -1.566  1.000 17.396  0  275 TYR A C     1 ? 
ATOM   2177 O O     . TYR A 1 275 ? 4.062   -15.878 -2.447  1.000 19.066  0  275 TYR A O     1 ? 
ATOM   2178 C CB    . TYR A 1 275 ? 6.812   -15.861 -2.245  1.000 17.845  0  275 TYR A CB    1 ? 
ATOM   2179 C CG    . TYR A 1 275 ? 8.310   -15.649 -2.288  1.000 18.550  0  275 TYR A CG    1 ? 
ATOM   2180 C CD1   . TYR A 1 275 ? 8.884   -14.685 -3.102  1.000 19.209  0  275 TYR A CD1   1 ? 
ATOM   2181 C CD2   . TYR A 1 275 ? 9.158   -16.441 -1.527  1.000 20.847  0  275 TYR A CD2   1 ? 
ATOM   2182 C CE1   . TYR A 1 275 ? 10.260  -14.518 -3.167  1.000 19.998  0  275 TYR A CE1   1 ? 
ATOM   2183 C CE2   . TYR A 1 275 ? 10.541  -16.289 -1.584  1.000 22.623  0  275 TYR A CE2   1 ? 
ATOM   2184 C CZ    . TYR A 1 275 ? 11.090  -15.325 -2.403  1.000 20.346  0  275 TYR A CZ    1 ? 
ATOM   2185 O OH    . TYR A 1 275 ? 12.448  -15.159 -2.434  1.000 23.710  0  275 TYR A OH    1 ? 
ATOM   2186 N N     . ASN A 1 276 ? 3.763   -14.639 -0.593  1.000 16.284  0  276 ASN A N     1 ? 
ATOM   2187 C CA    . ASN A 1 276 ? 2.326   -14.973 -0.453  1.000 17.950  0  276 ASN A CA    1 ? 
ATOM   2188 C C     . ASN A 1 276 ? 1.507   -14.151 -1.462  1.000 18.287  0  276 ASN A C     1 ? 
ATOM   2189 O O     . ASN A 1 276 ? 1.961   -13.075 -1.896  1.000 16.368  0  276 ASN A O     1 ? 
ATOM   2190 C CB    . ASN A 1 276 ? 1.876   -14.780 0.985   1.000 18.034  0  276 ASN A CB    1 ? 
ATOM   2191 C CG    . ASN A 1 276 ? 1.922   -13.332 1.406   1.000 21.192  0  276 ASN A CG    1 ? 
ATOM   2192 O OD1   . ASN A 1 276 ? 2.998   -12.732 1.549   1.000 19.310  0  276 ASN A OD1   1 ? 
ATOM   2193 N ND2   . ASN A 1 276 ? 0.752   -12.744 1.572   1.000 22.896  0  276 ASN A ND2   1 ? 
ATOM   2194 N N     . ASP A 1 277 ? 0.318   -14.640 -1.786  1.000 18.136  0  277 ASP A N     1 ? 
ATOM   2195 C CA    . ASP A 1 277 ? -0.711  -13.888 -2.544  1.000 16.687  0  277 ASP A CA    1 ? 
ATOM   2196 C C     . ASP A 1 277 ? -1.274  -12.815 -1.601  1.000 16.431  0  277 ASP A C     1 ? 
ATOM   2197 O O     . ASP A 1 277 ? -2.005  -13.140 -0.633  1.000 14.240  0  277 ASP A O     1 ? 
ATOM   2198 C CB    . ASP A 1 277 ? -1.767  -14.829 -3.123  1.000 18.218  0  277 ASP A CB    1 ? 
ATOM   2199 C CG    . ASP A 1 277 ? -2.918  -14.106 -3.794  1.000 17.634  0  277 ASP A CG    1 ? 
ATOM   2200 O OD1   . ASP A 1 277 ? -2.761  -12.906 -4.091  1.000 14.928  0  277 ASP A OD1   1 ? 
ATOM   2201 O OD2   . ASP A 1 277 ? -3.979  -14.700 -3.910  1.000 16.176  0  277 ASP A OD2   1 ? 
ATOM   2202 N N     . VAL A 1 278 ? -0.925  -11.564 -1.861  1.000 14.830  0  278 VAL A N     1 ? 
ATOM   2203 C CA    . VAL A 1 278 ? -1.342  -10.436 -0.993  1.000 17.015  0  278 VAL A CA    1 ? 
ATOM   2204 C C     . VAL A 1 278 ? -2.879  -10.297 -1.046  1.000 17.083  0  278 VAL A C     1 ? 
ATOM   2205 O O     . VAL A 1 278 ? -3.427  -9.712  -0.139  1.000 16.726  0  278 VAL A O     1 ? 
ATOM   2206 C CB    . VAL A 1 278 ? -0.630  -9.143  -1.386  1.000 19.798  0  278 VAL A CB    1 ? 
ATOM   2207 C CG1   . VAL A 1 278 ? 0.884   -9.231  -1.121  1.000 22.935  0  278 VAL A CG1   1 ? 
ATOM   2208 C CG2   . VAL A 1 278 ? -0.884  -8.799  -2.823  1.000 23.277  0  278 VAL A CG2   1 ? 
ATOM   2209 N N     . PHE A 1 279 ? -3.538  -10.797 -2.086  1.000 16.627  0  279 PHE A N     1 ? 
ATOM   2210 C CA    . PHE A 1 279 ? -5.011  -10.689 -2.239  1.000 17.157  0  279 PHE A CA    1 ? 
ATOM   2211 C C     . PHE A 1 279 ? -5.739  -11.944 -1.748  1.000 17.259  0  279 PHE A C     1 ? 
ATOM   2212 O O     . PHE A 1 279 ? -6.970  -12.025 -1.997  1.000 15.002  0  279 PHE A O     1 ? 
ATOM   2213 C CB    . PHE A 1 279 ? -5.366  -10.405 -3.698  1.000 18.056  0  279 PHE A CB    1 ? 
ATOM   2214 C CG    . PHE A 1 279 ? -5.045  -9.005  -4.148  1.000 17.922  0  279 PHE A CG    1 ? 
ATOM   2215 C CD1   . PHE A 1 279 ? -5.113  -7.936  -3.261  1.000 19.409  0  279 PHE A CD1   1 ? 
ATOM   2216 C CD2   . PHE A 1 279 ? -4.638  -8.753  -5.448  1.000 20.028  0  279 PHE A CD2   1 ? 
ATOM   2217 C CE1   . PHE A 1 279 ? -4.793  -6.658  -3.670  1.000 19.243  0  279 PHE A CE1   1 ? 
ATOM   2218 C CE2   . PHE A 1 279 ? -4.329  -7.457  -5.856  1.000 20.249  0  279 PHE A CE2   1 ? 
ATOM   2219 C CZ    . PHE A 1 279 ? -4.418  -6.418  -4.968  1.000 20.517  0  279 PHE A CZ    1 ? 
ATOM   2220 N N     . GLU A 1 280 ? -5.060  -12.852 -1.041  1.000 16.657  0  280 GLU A N     1 ? 
ATOM   2221 C CA    . GLU A 1 280 ? -5.591  -14.214 -0.769  1.000 20.250  0  280 GLU A CA    1 ? 
ATOM   2222 C C     . GLU A 1 280 ? -6.805  -14.136 0.182   1.000 21.353  0  280 GLU A C     1 ? 
ATOM   2223 O O     . GLU A 1 280 ? -7.634  -15.055 0.123   1.000 21.921  0  280 GLU A O     1 ? 
ATOM   2224 C CB    . GLU A 1 280 ? -4.508  -15.129 -0.178  1.000 22.764  0  280 GLU A CB    1 ? 
ATOM   2225 C CG    . GLU A 1 280 ? -3.918  -14.672 1.143   1.000 22.831  0  280 GLU A CG    1 ? 
ATOM   2226 C CD    . GLU A 1 280 ? -2.583  -15.351 1.441   1.000 27.039  0  280 GLU A CD    1 ? 
ATOM   2227 O OE1   . GLU A 1 280 ? -2.360  -16.459 0.914   1.000 28.425  0  280 GLU A OE1   1 ? 
ATOM   2228 O OE2   . GLU A 1 280 ? -1.743  -14.741 2.102   1.000 28.755  0  280 GLU A OE2   1 ? 
ATOM   2229 N N     . LYS A 1 281 ? -6.921  -13.078 0.983   1.000 21.099  0  281 LYS A N     1 ? 
ATOM   2230 C CA    . LYS A 1 281 ? -8.010  -12.940 1.991   1.000 24.203  0  281 LYS A CA    1 ? 
ATOM   2231 C C     . LYS A 1 281 ? -9.301  -12.429 1.318   1.000 22.924  0  281 LYS A C     1 ? 
ATOM   2232 O O     . LYS A 1 281 ? -10.410 -12.602 1.905   1.000 19.595  0  281 LYS A O     1 ? 
ATOM   2233 C CB    . LYS A 1 281 ? -7.554  -12.053 3.156   1.000 29.125  0  281 LYS A CB    1 ? 
ATOM   2234 C CG    . LYS A 1 281 ? -6.569  -12.711 4.133   1.000 33.151  0  281 LYS A CG    1 ? 
ATOM   2235 C CD    . LYS A 1 281 ? -6.966  -14.132 4.559   1.000 38.491  0  281 LYS A CD    1 ? 
ATOM   2236 C CE    . LYS A 1 281 ? -6.176  -14.672 5.740   1.000 46.636  0  281 LYS A CE    1 ? 
ATOM   2237 N NZ    . LYS A 1 281 ? -5.153  -15.668 5.328   1.000 49.462  0  281 LYS A NZ    1 ? 
ATOM   2238 N N     . MET A 1 282 ? -9.204  -11.864 0.121   1.000 17.855  0  282 MET A N     1 ? 
ATOM   2239 C CA    . MET A 1 282 ? -10.391 -11.349 -0.606  1.000 17.548  0  282 MET A CA    1 ? 
ATOM   2240 C C     . MET A 1 282 ? -11.264 -12.519 -1.057  1.000 15.774  0  282 MET A C     1 ? 
ATOM   2241 O O     . MET A 1 282 ? -10.717 -13.477 -1.616  1.000 15.815  0  282 MET A O     1 ? 
ATOM   2242 C CB    . MET A 1 282 ? -9.967  -10.514 -1.809  1.000 19.435  0  282 MET A CB    1 ? 
ATOM   2243 C CG    . MET A 1 282 ? -9.376  -9.186  -1.404  1.000 24.749  0  282 MET A CG    1 ? 
ATOM   2244 S SD    . MET A 1 282 ? -8.968  -8.126  -2.808  1.000 27.764  0  282 MET A SD    1 ? 
ATOM   2245 C CE    . MET A 1 282 ? -10.551 -8.204  -3.680  1.000 17.439  0  282 MET A CE    1 ? 
ATOM   2246 N N     . THR A 1 283 ? -12.591 -12.461 -0.841  1.000 14.153  0  283 THR A N     1 ? 
ATOM   2247 C CA    . THR A 1 283 ? -13.492 -13.586 -1.207  1.000 13.523  0  283 THR A CA    1 ? 
ATOM   2248 C C     . THR A 1 283 ? -13.662 -13.597 -2.724  1.000 13.346  0  283 THR A C     1 ? 
ATOM   2249 O O     . THR A 1 283 ? -13.302 -12.592 -3.362  1.000 10.628  0  283 THR A O     1 ? 
ATOM   2250 C CB    . THR A 1 283 ? -14.837 -13.491 -0.478  1.000 13.610  0  283 THR A CB    1 ? 
ATOM   2251 O OG1   . THR A 1 283 ? -15.503 -12.327 -0.983  1.000 13.168  0  283 THR A OG1   1 ? 
ATOM   2252 C CG2   . THR A 1 283 ? -14.661 -13.484 1.022   1.000 14.674  0  283 THR A CG2   1 ? 
ATOM   2253 N N     . GLY A 1 284 ? -14.243 -14.658 -3.292  1.000 11.761  0  284 GLY A N     1 ? 
ATOM   2254 C CA    . GLY A 1 284 ? -14.551 -14.687 -4.722  1.000 11.121  0  284 GLY A CA    1 ? 
ATOM   2255 C C     . GLY A 1 284 ? -15.534 -13.562 -5.102  1.000 12.565  0  284 GLY A C     1 ? 
ATOM   2256 O O     . GLY A 1 284 ? -15.385 -12.974 -6.178  1.000 12.550  0  284 GLY A O     1 ? 
ATOM   2257 N N     . MET A 1 285 ? -16.550 -13.292 -4.293  1.000 12.196  0  285 MET A N     1 ? 
ATOM   2258 C CA    . MET A 1 285 ? -17.545 -12.227 -4.618  1.000 14.120  0  285 MET A CA    1 ? 
ATOM   2259 C C     . MET A 1 285 ? -16.851 -10.835 -4.577  1.000 13.004  0  285 MET A C     1 ? 
ATOM   2260 O O     . MET A 1 285 ? -17.147 -10.001 -5.453  1.000 13.151  0  285 MET A O     1 ? 
ATOM   2261 C CB    . MET A 1 285 ? -18.696 -12.258 -3.609  1.000 17.175  0  285 MET A CB    1 ? 
ATOM   2262 C CG    . MET A 1 285 ? -19.720 -13.315 -3.923  1.000 20.017  0  285 MET A CG    1 ? 
ATOM   2263 S SD    . MET A 1 285 ? -20.581 -13.047 -5.472  1.000 23.388  0  285 MET A SD    1 ? 
ATOM   2264 C CE    . MET A 1 285 ? -21.774 -14.388 -5.392  1.000 29.062  0  285 MET A CE    1 ? 
ATOM   2265 N N     . GLN A 1 286 ? -15.960 -10.616 -3.612  1.000 12.373  0  286 GLN A N     1 ? 
ATOM   2266 C CA    . GLN A 1 286 ? -15.162 -9.363  -3.508  1.000 12.764  0  286 GLN A CA    1 ? 
ATOM   2267 C C     . GLN A 1 286 ? -14.250 -9.252  -4.735  1.000 12.177  0  286 GLN A C     1 ? 
ATOM   2268 O O     . GLN A 1 286 ? -14.084 -8.137  -5.259  1.000 10.942  0  286 GLN A O     1 ? 
ATOM   2269 C CB    . GLN A 1 286 ? -14.364 -9.321  -2.221  1.000 12.749  0  286 GLN A CB    1 ? 
ATOM   2270 C CG    . GLN A 1 286 ? -15.248 -9.127  -1.016  1.000 16.159  0  286 GLN A CG    1 ? 
ATOM   2271 C CD    . GLN A 1 286 ? -14.535 -9.400  0.278   1.000 18.198  0  286 GLN A CD    1 ? 
ATOM   2272 O OE1   . GLN A 1 286 ? -13.460 -10.019 0.314   1.000 18.445  0  286 GLN A OE1   1 ? 
ATOM   2273 N NE2   . GLN A 1 286 ? -15.174 -8.982  1.365   1.000 20.228  0  286 GLN A NE2   1 ? 
ATOM   2274 N N     . MET A 1 287 ? -13.724 -10.384 -5.223  1.000 12.656  0  287 MET A N     1 ? 
ATOM   2275 C CA    . MET A 1 287 ? -12.873 -10.377 -6.435  1.000 13.122  0  287 MET A CA    1 ? 
ATOM   2276 C C     . MET A 1 287 ? -13.705 -10.020 -7.657  1.000 12.743  0  287 MET A C     1 ? 
ATOM   2277 O O     . MET A 1 287 ? -13.193 -9.286  -8.510  1.000 13.043  0  287 MET A O     1 ? 
ATOM   2278 C CB    . MET A 1 287 ? -12.152 -11.716 -6.661  1.000 12.481  0  287 MET A CB    1 ? 
ATOM   2279 C CG    . MET A 1 287 ? -10.892 -11.770 -5.859  1.000 13.074  0  287 MET A CG    1 ? 
ATOM   2280 S SD    . MET A 1 287 ? -9.614  -10.863 -6.668  1.000 13.157  0  287 MET A SD    1 ? 
ATOM   2281 C CE    . MET A 1 287 ? -8.299  -11.014 -5.467  1.000 13.775  0  287 MET A CE    1 ? 
ATOM   2282 N N     . GLU A 1 288 ? -14.919 -10.570 -7.785  1.000 12.660  0  288 GLU A N     1 ? 
ATOM   2283 C CA    . GLU A 1 288 ? -15.799 -10.285 -8.933  1.000 12.701  0  288 GLU A CA    1 ? 
ATOM   2284 C C     . GLU A 1 288 ? -16.068 -8.771  -8.934  1.000 12.117  0  288 GLU A C     1 ? 
ATOM   2285 O O     . GLU A 1 288 ? -16.046 -8.177  -10.001 1.000 11.266  0  288 GLU A O     1 ? 
ATOM   2286 C CB    . GLU A 1 288 ? -17.107 -11.076 -8.787  1.000 15.265  0  288 GLU A CB    1 ? 
ATOM   2287 C CG    . GLU A 1 288 ? -18.043 -10.928 -9.935  1.000 18.022  0  288 GLU A CG    1 ? 
ATOM   2288 C CD    . GLU A 1 288 ? -19.317 -11.738 -9.744  1.000 22.114  0  288 GLU A CD    1 ? 
ATOM   2289 O OE1   . GLU A 1 288 ? -20.097 -11.431 -8.792  1.000 22.433  0  288 GLU A OE1   1 ? 
ATOM   2290 O OE2   . GLU A 1 288 ? -19.448 -12.752 -10.443 1.000 23.438  0  288 GLU A OE2   1 ? 
ATOM   2291 N N     . SER A 1 289 ? -16.304 -8.186  -7.762  1.000 11.969  0  289 SER A N     1 ? 
ATOM   2292 C CA    . SER A 1 289 ? -16.636 -6.736  -7.627  1.000 12.578  0  289 SER A CA    1 ? 
ATOM   2293 C C     . SER A 1 289 ? -15.391 -5.901  -7.982  1.000 11.503  0  289 SER A C     1 ? 
ATOM   2294 O O     . SER A 1 289 ? -15.528 -4.933  -8.761  1.000 11.297  0  289 SER A O     1 ? 
ATOM   2295 C CB    . SER A 1 289 ? -17.215 -6.409  -6.284  1.000 14.939  0  289 SER A CB    1 ? 
ATOM   2296 O OG    . SER A 1 289 ? -17.496 -5.019  -6.194  1.000 19.986  0  289 SER A OG    1 ? 
ATOM   2297 N N     . PHE A 1 290 ? -14.219 -6.301  -7.496  1.000 11.168  0  290 PHE A N     1 ? 
ATOM   2298 C CA    . PHE A 1 290 ? -12.894 -5.714  -7.838  1.000 11.452  0  290 PHE A CA    1 ? 
ATOM   2299 C C     . PHE A 1 290 ? -12.715 -5.719  -9.373  1.000 11.659  0  290 PHE A C     1 ? 
ATOM   2300 O O     . PHE A 1 290 ? -12.406 -4.700  -9.976  1.000 10.707  0  290 PHE A O     1 ? 
ATOM   2301 C CB    . PHE A 1 290 ? -11.824 -6.477  -7.049  1.000 11.143  0  290 PHE A CB    1 ? 
ATOM   2302 C CG    . PHE A 1 290 ? -10.376 -6.067  -7.228  1.000 11.278  0  290 PHE A CG    1 ? 
ATOM   2303 C CD1   . PHE A 1 290 ? -10.012 -4.821  -7.725  1.000 10.925  0  290 PHE A CD1   1 ? 
ATOM   2304 C CD2   . PHE A 1 290 ? -9.379  -6.957  -6.880  1.000 12.260  0  290 PHE A CD2   1 ? 
ATOM   2305 C CE1   . PHE A 1 290 ? -8.672  -4.485  -7.890  1.000 12.209  0  290 PHE A CE1   1 ? 
ATOM   2306 C CE2   . PHE A 1 290 ? -8.040  -6.641  -7.059  1.000 13.066  0  290 PHE A CE2   1 ? 
ATOM   2307 C CZ    . PHE A 1 290 ? -7.683  -5.393  -7.546  1.000 12.684  0  290 PHE A CZ    1 ? 
ATOM   2308 N N     . LYS A 1 291 ? -12.911 -6.862  -10.016 1.000 11.622  0  291 LYS A N     1 ? 
ATOM   2309 C CA    . LYS A 1 291 ? -12.737 -6.990  -11.480 1.000 11.960  0  291 LYS A CA    1 ? 
ATOM   2310 C C     . LYS A 1 291 ? -13.706 -6.059  -12.218 1.000 12.020  0  291 LYS A C     1 ? 
ATOM   2311 O O     . LYS A 1 291 ? -13.294 -5.371  -13.164 1.000 10.659  0  291 LYS A O     1 ? 
ATOM   2312 C CB    . LYS A 1 291 ? -12.957 -8.432  -11.945 1.000 12.591  0  291 LYS A CB    1 ? 
ATOM   2313 C CG    . LYS A 1 291 ? -12.528 -8.656  -13.389 1.000 14.209  0  291 LYS A CG    1 ? 
ATOM   2314 C CD    . LYS A 1 291 ? -12.664 -10.069 -13.882 1.000 15.946  0  291 LYS A CD    1 ? 
ATOM   2315 C CE    . LYS A 1 291 ? -12.149 -10.223 -15.308 1.000 19.982  0  291 LYS A CE    1 ? 
ATOM   2316 N NZ    . LYS A 1 291 ? -12.451 -11.582 -15.827 1.000 22.191  0  291 LYS A NZ    1 ? 
ATOM   2317 N N     . SER A 1 292 ? -14.970 -6.026  -11.825 1.000 13.268  0  292 SER A N     1 ? 
ATOM   2318 C CA    . SER A 1 292 ? -15.971 -5.172  -12.503 1.000 13.505  0  292 SER A CA    1 ? 
ATOM   2319 C C     . SER A 1 292 ? -15.607 -3.677  -12.372 1.000 12.503  0  292 SER A C     1 ? 
ATOM   2320 O O     . SER A 1 292 ? -15.724 -2.951  -13.372 1.000 12.422  0  292 SER A O     1 ? 
ATOM   2321 C CB    . SER A 1 292 ? -17.349 -5.448  -11.998 1.000 15.397  0  292 SER A CB    1 ? 
ATOM   2322 O OG    . SER A 1 292 ? -17.674 -6.802  -12.310 1.000 22.768  0  292 SER A OG    1 ? 
ATOM   2323 N N     . LYS A 1 293 ? -15.146 -3.236  -11.209 1.000 12.099  0  293 LYS A N     1 ? 
ATOM   2324 C CA    . LYS A 1 293 ? -14.751 -1.814  -11.028 1.000 12.156  0  293 LYS A CA    1 ? 
ATOM   2325 C C     . LYS A 1 293 ? -13.462 -1.522  -11.790 1.000 11.689  0  293 LYS A C     1 ? 
ATOM   2326 O O     . LYS A 1 293 ? -13.352 -0.454  -12.366 1.000 9.695   0  293 LYS A O     1 ? 
ATOM   2327 C CB    . LYS A 1 293 ? -14.682 -1.502  -9.551  1.000 13.081  0  293 LYS A CB    1 ? 
ATOM   2328 C CG    . LYS A 1 293 ? -16.080 -1.297  -9.011  1.000 14.668  0  293 LYS A CG    1 ? 
ATOM   2329 C CD    . LYS A 1 293 ? -16.094 -0.780  -7.595  1.000 15.853  0  293 LYS A CD    1 ? 
ATOM   2330 C CE    . LYS A 1 293 ? -15.911 -1.890  -6.625  1.000 14.796  0  293 LYS A CE    1 ? 
ATOM   2331 N NZ    . LYS A 1 293 ? -16.310 -1.464  -5.266  1.000 15.264  0  293 LYS A NZ    1 ? 
ATOM   2332 N N     . LEU A 1 294 ? -12.523 -2.453  -11.818 1.000 11.267  0  294 LEU A N     1 ? 
ATOM   2333 C CA    . LEU A 1 294 ? -11.314 -2.292  -12.648 1.000 12.819  0  294 LEU A CA    1 ? 
ATOM   2334 C C     . LEU A 1 294 ? -11.709 -2.143  -14.122 1.000 11.668  0  294 LEU A C     1 ? 
ATOM   2335 O O     . LEU A 1 294 ? -11.116 -1.288  -14.817 1.000 10.237  0  294 LEU A O     1 ? 
ATOM   2336 C CB    . LEU A 1 294 ? -10.420 -3.511  -12.409 1.000 15.292  0  294 LEU A CB    1 ? 
ATOM   2337 C CG    . LEU A 1 294 ? -8.911  -3.337  -12.416 1.000 20.863  0  294 LEU A CG    1 ? 
ATOM   2338 C CD1   . LEU A 1 294 ? -8.456  -2.109  -11.638 1.000 20.088  0  294 LEU A CD1   1 ? 
ATOM   2339 C CD2   . LEU A 1 294 ? -8.266  -4.615  -11.834 1.000 20.065  0  294 LEU A CD2   1 ? 
ATOM   2340 N N     . GLN A 1 295 ? -12.631 -2.973  -14.606 1.000 12.253  0  295 GLN A N     1 ? 
ATOM   2341 C CA    . GLN A 1 295 ? -13.124 -2.914  -15.998 1.000 12.283  0  295 GLN A CA    1 ? 
ATOM   2342 C C     . GLN A 1 295 ? -13.760 -1.544  -16.258 1.000 12.221  0  295 GLN A C     1 ? 
ATOM   2343 O O     . GLN A 1 295 ? -13.474 -0.964  -17.313 1.000 12.847  0  295 GLN A O     1 ? 
ATOM   2344 C CB    . GLN A 1 295 ? -14.082 -4.062  -16.298 1.000 13.116  0  295 GLN A CB    1 ? 
ATOM   2345 C CG    . GLN A 1 295 ? -14.516 -4.110  -17.760 1.000 15.757  0  295 GLN A CG    1 ? 
ATOM   2346 C CD    . GLN A 1 295 ? -13.349 -4.459  -18.675 1.000 16.557  0  295 GLN A CD    1 ? 
ATOM   2347 O OE1   . GLN A 1 295 ? -12.687 -5.491  -18.513 1.000 18.967  0  295 GLN A OE1   1 ? 
ATOM   2348 N NE2   . GLN A 1 295 ? -13.043 -3.575  -19.616 1.000 17.572  0  295 GLN A NE2   1 ? 
ATOM   2349 N N     . ALA A 1 296 ? -14.628 -1.074  -15.363 1.000 12.052  0  296 ALA A N     1 ? 
ATOM   2350 C CA    . ALA A 1 296 ? -15.263 0.265   -15.462 1.000 11.685  0  296 ALA A CA    1 ? 
ATOM   2351 C C     . ALA A 1 296 ? -14.168 1.346   -15.518 1.000 10.282  0  296 ALA A C     1 ? 
ATOM   2352 O O     . ALA A 1 296 ? -14.302 2.259   -16.350 1.000 9.532   0  296 ALA A O     1 ? 
ATOM   2353 C CB    . ALA A 1 296 ? -16.220 0.487   -14.321 1.000 11.875  0  296 ALA A CB    1 ? 
ATOM   2354 N N     . LEU A 1 297 ? -13.112 1.241   -14.689 1.000 10.267  0  297 LEU A N     1 ? 
ATOM   2355 C CA    . LEU A 1 297 ? -11.989 2.211   -14.693 1.000 10.806  0  297 LEU A CA    1 ? 
ATOM   2356 C C     . LEU A 1 297 ? -11.317 2.131   -16.071 1.000 10.264  0  297 LEU A C     1 ? 
ATOM   2357 O O     . LEU A 1 297 ? -11.066 3.183   -16.665 1.000 10.258  0  297 LEU A O     1 ? 
ATOM   2358 C CB    . LEU A 1 297 ? -10.995 1.922   -13.552 1.000 11.251  0  297 LEU A CB    1 ? 
ATOM   2359 C CG    . LEU A 1 297 ? -9.710  2.765   -13.581 1.000 11.112  0  297 LEU A CG    1 ? 
ATOM   2360 C CD1   . LEU A 1 297 ? -10.021 4.269   -13.552 1.000 12.438  0  297 LEU A CD1   1 ? 
ATOM   2361 C CD2   . LEU A 1 297 ? -8.834  2.398   -12.402 1.000 12.640  0  297 LEU A CD2   1 ? 
ATOM   2362 N N     . LEU A 1 298 ? -11.039 0.933   -16.573 1.000 11.008  0  298 LEU A N     1 ? 
ATOM   2363 C CA    . LEU A 1 298 ? -10.375 0.780   -17.906 1.000 11.942  0  298 LEU A CA    1 ? 
ATOM   2364 C C     . LEU A 1 298 ? -11.217 1.489   -18.962 1.000 11.977  0  298 LEU A C     1 ? 
ATOM   2365 O O     . LEU A 1 298 ? -10.668 2.203   -19.796 1.000 11.335  0  298 LEU A O     1 ? 
ATOM   2366 C CB    . LEU A 1 298 ? -10.226 -0.720  -18.228 1.000 13.226  0  298 LEU A CB    1 ? 
ATOM   2367 C CG    . LEU A 1 298 ? -9.521  -1.099  -19.530 1.000 15.101  0  298 LEU A CG    1 ? 
ATOM   2368 C CD1   . LEU A 1 298 ? -10.373 -0.813  -20.743 1.000 18.117  0  298 LEU A CD1   1 ? 
ATOM   2369 C CD2   . LEU A 1 298 ? -8.194  -0.396  -19.671 1.000 18.396  0  298 LEU A CD2   1 ? 
ATOM   2370 N N     . ASN A 1 299 ? -12.531 1.238   -18.961 1.000 12.675  0  299 ASN A N     1 ? 
ATOM   2371 C CA    . ASN A 1 299 ? -13.492 1.818   -19.922 1.000 13.488  0  299 ASN A CA    1 ? 
ATOM   2372 C C     . ASN A 1 299 ? -13.415 3.353   -19.856 1.000 12.730  0  299 ASN A C     1 ? 
ATOM   2373 O O     . ASN A 1 299 ? -13.451 4.002   -20.918 1.000 14.055  0  299 ASN A O     1 ? 
ATOM   2374 C CB    . ASN A 1 299 ? -14.908 1.261   -19.685 1.000 15.724  0  299 ASN A CB    1 ? 
ATOM   2375 C CG    . ASN A 1 299 ? -15.048 -0.238  -19.954 1.000 18.526  0  299 ASN A CG    1 ? 
ATOM   2376 O OD1   . ASN A 1 299 ? -14.154 -0.899  -20.457 1.000 20.062  0  299 ASN A OD1   1 ? 
ATOM   2377 N ND2   . ASN A 1 299 ? -16.189 -0.804  -19.614 1.000 22.617  0  299 ASN A ND2   1 ? 
ATOM   2378 N N     . ALA A 1 300 ? -13.289 3.930   -18.675 1.000 10.808  0  300 ALA A N     1 ? 
ATOM   2379 C CA    . ALA A 1 300 ? -13.217 5.386   -18.506 1.000 11.284  0  300 ALA A CA    1 ? 
ATOM   2380 C C     . ALA A 1 300 ? -11.864 5.908   -19.060 1.000 11.342  0  300 ALA A C     1 ? 
ATOM   2381 O O     . ALA A 1 300 ? -11.863 6.953   -19.731 1.000 11.148  0  300 ALA A O     1 ? 
ATOM   2382 C CB    . ALA A 1 300 ? -13.396 5.746   -17.074 1.000 11.365  0  300 ALA A CB    1 ? 
ATOM   2383 N N     . LEU A 1 301 ? -10.758 5.204   -18.793 1.000 12.277  0  301 LEU A N     1 ? 
ATOM   2384 C CA    . LEU A 1 301 ? -9.429  5.584   -19.336 1.000 12.015  0  301 LEU A CA    1 ? 
ATOM   2385 C C     . LEU A 1 301 ? -9.505  5.603   -20.877 1.000 13.097  0  301 LEU A C     1 ? 
ATOM   2386 O O     . LEU A 1 301 ? -8.954  6.512   -21.504 1.000 13.454  0  301 LEU A O     1 ? 
ATOM   2387 C CB    . LEU A 1 301 ? -8.344  4.646   -18.811 1.000 11.846  0  301 LEU A CB    1 ? 
ATOM   2388 C CG    . LEU A 1 301 ? -8.032  4.773   -17.318 1.000 12.380  0  301 LEU A CG    1 ? 
ATOM   2389 C CD1   . LEU A 1 301 ? -7.247  3.574   -16.802 1.000 12.237  0  301 LEU A CD1   1 ? 
ATOM   2390 C CD2   . LEU A 1 301 ? -7.302  6.077   -17.019 1.000 12.484  0  301 LEU A CD2   1 ? 
ATOM   2391 N N     . LYS A 1 302 ? -10.181 4.655   -21.492 1.000 14.058  0  302 LYS A N     1 ? 
ATOM   2392 C CA    . LYS A 1 302 ? -10.306 4.626   -22.973 1.000 16.276  0  302 LYS A CA    1 ? 
ATOM   2393 C C     . LYS A 1 302 ? -11.232 5.751   -23.468 1.000 17.332  0  302 LYS A C     1 ? 
ATOM   2394 O O     . LYS A 1 302 ? -10.915 6.395   -24.497 1.000 17.834  0  302 LYS A O     1 ? 
ATOM   2395 C CB    . LYS A 1 302 ? -10.796 3.243   -23.419 1.000 18.243  0  302 LYS A CB    1 ? 
ATOM   2396 C CG    . LYS A 1 302 ? -9.721  2.190   -23.441 1.000 17.975  0  302 LYS A CG    1 ? 
ATOM   2397 C CD    . LYS A 1 302 ? -10.214 0.848   -23.961 1.000 21.445  0  302 LYS A CD    1 ? 
ATOM   2398 C CE    . LYS A 1 302 ? -9.072  -0.124  -24.136 1.000 23.177  0  302 LYS A CE    1 ? 
ATOM   2399 N NZ    . LYS A 1 302 ? -9.529  -1.397  -24.738 1.000 29.392  0  302 LYS A NZ    1 ? 
ATOM   2400 N N     . THR A 1 303 ? -12.344 6.003   -22.796 1.000 18.918  0  303 THR A N     1 ? 
ATOM   2401 C CA    . THR A 1 303 ? -13.286 7.101   -23.155 1.000 20.598  0  303 THR A CA    1 ? 
ATOM   2402 C C     . THR A 1 303 ? -12.529 8.428   -23.098 1.000 20.958  0  303 THR A C     1 ? 
ATOM   2403 O O     . THR A 1 303 ? -12.721 9.276   -24.006 1.000 20.451  0  303 THR A O     1 ? 
ATOM   2404 C CB    . THR A 1 303 ? -14.516 7.105   -22.234 1.000 22.117  0  303 THR A CB    1 ? 
ATOM   2405 O OG1   . THR A 1 303 ? -15.133 5.831   -22.347 1.000 23.489  0  303 THR A OG1   1 ? 
ATOM   2406 C CG2   . THR A 1 303 ? -15.521 8.181   -22.569 1.000 25.481  0  303 THR A CG2   1 ? 
ATOM   2407 N N     . ALA A 1 304 ? -11.667 8.606   -22.084 1.000 19.372  0  304 ALA A N     1 ? 
ATOM   2408 C CA    . ALA A 1 304 ? -10.936 9.866   -21.855 1.000 20.018  0  304 ALA A CA    1 ? 
ATOM   2409 C C     . ALA A 1 304 ? -9.943  10.118  -22.997 1.000 21.543  0  304 ALA A C     1 ? 
ATOM   2410 O O     . ALA A 1 304 ? -9.437  11.251  -23.070 1.000 24.403  0  304 ALA A O     1 ? 
ATOM   2411 C CB    . ALA A 1 304 ? -10.221 9.862   -20.541 1.000 18.562  0  304 ALA A CB    1 ? 
ATOM   2412 N N     . LYS A 1 305 ? -9.554  9.084   -23.750 1.000 19.459  0  305 LYS A N     1 ? 
ATOM   2413 C CA    . LYS A 1 305 ? -8.595  9.239   -24.861 1.000 20.631  0  305 LYS A CA    1 ? 
ATOM   2414 C C     . LYS A 1 305 ? -9.379  9.824   -26.047 1.000 24.934  0  305 LYS A C     1 ? 
ATOM   2415 O O     . LYS A 1 305 ? -8.779  10.532  -26.832 1.000 31.105  0  305 LYS A O     1 ? 
ATOM   2416 C CB    . LYS A 1 305 ? -7.968  7.891   -25.226 1.000 21.897  0  305 LYS A CB    1 ? 
ATOM   2417 C CG    . LYS A 1 305 ? -6.845  7.935   -26.247 1.000 23.156  0  305 LYS A CG    1 ? 
ATOM   2418 C CD    . LYS A 1 305 ? -6.335  6.544   -26.632 1.000 24.158  0  305 LYS A CD    1 ? 
ATOM   2419 C CE    . LYS A 1 305 ? -5.164  6.581   -27.597 1.000 26.119  0  305 LYS A CE    1 ? 
ATOM   2420 N NZ    . LYS A 1 305 ? -4.628  5.216   -27.869 1.000 25.950  0  305 LYS A NZ    1 ? 
ATOM   2421 N N     . SER A 1 306 ? -10.679 9.516   -26.150 1.000 28.481  0  306 SER A N     1 ? 
ATOM   2422 C CA    . SER A 1 306 ? -11.486 9.648   -27.399 1.000 30.759  0  306 SER A CA    1 ? 
ATOM   2423 C C     . SER A 1 306 ? -12.387 10.898  -27.381 1.000 33.440  0  306 SER A C     1 ? 
ATOM   2424 O O     . SER A 1 306 ? -12.897 11.247  -28.450 1.000 33.514  0  306 SER A O     1 ? 
ATOM   2425 C CB    . SER A 1 306 ? -12.288 8.407   -27.635 1.000 33.373  0  306 SER A CB    1 ? 
ATOM   2426 O OG    . SER A 1 306 ? -13.424 8.374   -26.785 1.000 39.305  0  306 SER A OG    1 ? 
ATOM   2427 N N     . ARG A 1 307 ? -12.601 11.548  -26.229 1.000 33.762  0  307 ARG A N     1 ? 
ATOM   2428 C CA    . ARG A 1 307 ? -13.503 12.736  -26.107 1.000 35.743  0  307 ARG A CA    1 ? 
ATOM   2429 C C     . ARG A 1 307 ? -12.915 13.947  -26.854 1.000 36.118  0  307 ARG A C     1 ? 
ATOM   2430 O O     . ARG A 1 307 ? -11.711 14.195  -26.697 1.000 36.329  0  307 ARG A O     1 ? 
ATOM   2431 C CB    . ARG A 1 307 ? -13.698 13.132  -24.641 1.000 36.459  0  307 ARG A CB    1 ? 
ATOM   2432 C CG    . ARG A 1 307 ? -14.449 12.118  -23.792 1.000 37.762  0  307 ARG A CG    1 ? 
ATOM   2433 C CD    . ARG A 1 307 ? -15.793 11.728  -24.365 1.000 41.105  0  307 ARG A CD    1 ? 
ATOM   2434 N NE    . ARG A 1 307 ? -15.634 10.718  -25.395 1.000 42.710  0  307 ARG A NE    1 ? 
ATOM   2435 C CZ    . ARG A 1 307 ? -16.602 9.919   -25.833 1.000 47.627  0  307 ARG A CZ    1 ? 
ATOM   2436 N NH1   . ARG A 1 307 ? -16.338 9.025   -26.770 1.000 45.612  0  307 ARG A NH1   1 ? 
ATOM   2437 N NH2   . ARG A 1 307 ? -17.815 9.979   -25.303 1.000 53.562  0  307 ARG A NH2   1 ? 
ATOM   2438 N N     . LEU A 1 308 ? -13.747 14.735  -27.551 1.000 37.534  0  308 LEU A N     1 ? 
ATOM   2439 C CA    . LEU A 1 308 ? -13.280 15.999  -28.197 1.000 44.891  0  308 LEU A CA    1 ? 
ATOM   2440 C C     . LEU A 1 308 ? -13.190 17.109  -27.140 1.000 39.673  0  308 LEU A C     1 ? 
ATOM   2441 O O     . LEU A 1 308 ? -12.308 17.970  -27.274 1.000 43.953  0  308 LEU A O     1 ? 
ATOM   2442 C CB    . LEU A 1 308 ? -14.159 16.413  -29.394 1.000 52.093  0  308 LEU A CB    1 ? 
ATOM   2443 C CG    . LEU A 1 308 ? -15.682 16.411  -29.228 1.000 57.084  0  308 LEU A CG    1 ? 
ATOM   2444 C CD1   . LEU A 1 308 ? -16.165 17.586  -28.392 1.000 61.051  0  308 LEU A CD1   1 ? 
ATOM   2445 C CD2   . LEU A 1 308 ? -16.353 16.450  -30.600 1.000 61.811  0  308 LEU A CD2   1 ? 
ATOM   2446 N N     . GLU A 1 309 ? -14.023 17.050  -26.105 1.000 29.623  0  309 GLU A N     1 ? 
ATOM   2447 C CA    . GLU A 1 309 ? -14.084 18.075  -25.047 1.000 28.003  0  309 GLU A CA    1 ? 
ATOM   2448 C C     . GLU A 1 309 ? -13.242 17.572  -23.869 1.000 24.934  0  309 GLU A C     1 ? 
ATOM   2449 O O     . GLU A 1 309 ? -13.550 16.481  -23.364 1.000 20.073  0  309 GLU A O     1 ? 
ATOM   2450 C CB    . GLU A 1 309 ? -15.540 18.307  -24.648 1.000 32.036  0  309 GLU A CB    1 ? 
ATOM   2451 C CG    . GLU A 1 309 ? -15.899 19.749  -24.339 1.000 41.223  0  309 GLU A CG    1 ? 
ATOM   2452 C CD    . GLU A 1 309 ? -15.663 20.786  -25.437 1.000 41.139  0  309 GLU A CD    1 ? 
ATOM   2453 O OE1   . GLU A 1 309 ? -16.504 20.896  -26.385 1.000 40.927  0  309 GLU A OE1   1 ? 
ATOM   2454 O OE2   . GLU A 1 309 ? -14.664 21.525  -25.325 1.000 43.696  0  309 GLU A OE2   1 ? 
ATOM   2455 N N     . LEU A 1 310 ? -12.227 18.333  -23.460 1.000 21.695  0  310 LEU A N     1 ? 
ATOM   2456 C CA    . LEU A 1 310 ? -11.426 18.025  -22.251 1.000 21.218  0  310 LEU A CA    1 ? 
ATOM   2457 C C     . LEU A 1 310 ? -12.389 17.891  -21.054 1.000 18.907  0  310 LEU A C     1 ? 
ATOM   2458 O O     . LEU A 1 310 ? -12.140 17.060  -20.207 1.000 18.149  0  310 LEU A O     1 ? 
ATOM   2459 C CB    . LEU A 1 310 ? -10.409 19.148  -22.029 1.000 22.477  0  310 LEU A CB    1 ? 
ATOM   2460 C CG    . LEU A 1 310 ? -9.441  18.944  -20.855 1.000 23.303  0  310 LEU A CG    1 ? 
ATOM   2461 C CD1   . LEU A 1 310 ? -8.511  17.769  -21.103 1.000 25.884  0  310 LEU A CD1   1 ? 
ATOM   2462 C CD2   . LEU A 1 310 ? -8.639  20.198  -20.613 1.000 26.408  0  310 LEU A CD2   1 ? 
ATOM   2463 N N     . HIS A 1 311 ? -13.457 18.696  -20.988 1.000 16.537  0  311 HIS A N     1 ? 
ATOM   2464 C CA    . HIS A 1 311 ? -14.466 18.588  -19.892 1.000 16.959  0  311 HIS A CA    1 ? 
ATOM   2465 C C     . HIS A 1 311 ? -14.976 17.147  -19.786 1.000 15.211  0  311 HIS A C     1 ? 
ATOM   2466 O O     . HIS A 1 311 ? -15.043 16.606  -18.672 1.000 16.236  0  311 HIS A O     1 ? 
ATOM   2467 C CB    . HIS A 1 311 ? -15.650 19.530  -20.078 1.000 16.574  0  311 HIS A CB    1 ? 
ATOM   2468 C CG    . HIS A 1 311 ? -16.763 19.243  -19.120 1.000 16.761  0  311 HIS A CG    1 ? 
ATOM   2469 N ND1   . HIS A 1 311 ? -16.836 19.826  -17.871 1.000 18.870  0  311 HIS A ND1   1 ? 
ATOM   2470 C CD2   . HIS A 1 311 ? -17.830 18.431  -19.212 1.000 18.884  0  311 HIS A CD2   1 ? 
ATOM   2471 C CE1   . HIS A 1 311 ? -17.910 19.392  -17.237 1.000 18.044  0  311 HIS A CE1   1 ? 
ATOM   2472 N NE2   . HIS A 1 311 ? -18.535 18.537  -18.031 1.000 20.124  0  311 HIS A NE2   1 ? 
ATOM   2473 N N     . ASP A 1 312 ? -15.353 16.558  -20.899 1.000 15.988  0  312 ASP A N     1 ? 
ATOM   2474 C CA    . ASP A 1 312 ? -15.981 15.212  -20.927 1.000 18.201  0  312 ASP A CA    1 ? 
ATOM   2475 C C     . ASP A 1 312 ? -14.918 14.141  -20.592 1.000 17.355  0  312 ASP A C     1 ? 
ATOM   2476 O O     . ASP A 1 312 ? -15.254 13.171  -19.904 1.000 17.756  0  312 ASP A O     1 ? 
ATOM   2477 C CB    . ASP A 1 312 ? -16.628 14.912  -22.288 1.000 18.294  0  312 ASP A CB    1 ? 
ATOM   2478 C CG    . ASP A 1 312 ? -17.773 15.831  -22.688 1.000 21.167  0  312 ASP A CG    1 ? 
ATOM   2479 O OD1   . ASP A 1 312 ? -18.285 16.554  -21.840 1.000 21.967  0  312 ASP A OD1   1 ? 
ATOM   2480 O OD2   . ASP A 1 312 ? -18.038 15.898  -23.892 1.000 25.399  0  312 ASP A OD2   1 ? 
ATOM   2481 N N     . ALA A 1 313 ? -13.701 14.274  -21.103 1.000 18.446  0  313 ALA A N     1 ? 
ATOM   2482 C CA    . ALA A 1 313 ? -12.578 13.348  -20.795 1.000 17.224  0  313 ALA A CA    1 ? 
ATOM   2483 C C     . ALA A 1 313 ? -12.319 13.333  -19.277 1.000 17.164  0  313 ALA A C     1 ? 
ATOM   2484 O O     . ALA A 1 313 ? -12.231 12.221  -18.676 1.000 16.133  0  313 ALA A O     1 ? 
ATOM   2485 C CB    . ALA A 1 313 ? -11.342 13.754  -21.565 1.000 17.052  0  313 ALA A CB    1 ? 
ATOM   2486 N N     . CYS A 1 314 ? -12.222 14.514  -18.658 1.000 14.252  0  314 CYS A N     1 ? 
ATOM   2487 C CA    . CYS A 1 314 ? -11.897 14.652  -17.221 1.000 13.305  0  314 CYS A CA    1 ? 
ATOM   2488 C C     . CYS A 1 314 ? -13.055 14.203  -16.345 1.000 13.270  0  314 CYS A C     1 ? 
ATOM   2489 O O     . CYS A 1 314 ? -12.801 13.464  -15.385 1.000 12.984  0  314 CYS A O     1 ? 
ATOM   2490 C CB    . CYS A 1 314 ? -11.498 16.066  -16.892 1.000 12.713  0  314 CYS A CB    1 ? 
ATOM   2491 S SG    . CYS A 1 314 ? -9.912  16.481  -17.656 1.000 14.288  0  314 CYS A SG    1 ? 
ATOM   2492 N N     . LYS A 1 315 ? -14.282 14.558  -16.718 1.000 14.595  0  315 LYS A N     1 ? 
ATOM   2493 C CA    . LYS A 1 315 ? -15.506 14.101  -16.019 1.000 15.869  0  315 LYS A CA    1 ? 
ATOM   2494 C C     . LYS A 1 315 ? -15.543 12.571  -15.976 1.000 14.936  0  315 LYS A C     1 ? 
ATOM   2495 O O     . LYS A 1 315 ? -15.854 12.042  -14.892 1.000 13.589  0  315 LYS A O     1 ? 
ATOM   2496 C CB    . LYS A 1 315 ? -16.765 14.630  -16.705 1.000 19.566  0  315 LYS A CB    1 ? 
ATOM   2497 C CG    . LYS A 1 315 ? -18.052 14.210  -16.017 1.000 23.122  0  315 LYS A CG    1 ? 
ATOM   2498 C CD    . LYS A 1 315 ? -18.424 15.098  -14.882 1.000 29.644  0  315 LYS A CD    1 ? 
ATOM   2499 C CE    . LYS A 1 315 ? -17.514 14.968  -13.685 1.000 34.001  0  315 LYS A CE    1 ? 
ATOM   2500 N NZ    . LYS A 1 315 ? -18.241 15.283  -12.431 1.000 39.608  0  315 LYS A NZ    1 ? 
ATOM   2501 N N     . ALA A 1 316 ? -15.162 11.902  -17.067 1.000 14.362  0  316 ALA A N     1 ? 
ATOM   2502 C CA    . ALA A 1 316 ? -15.208 10.421  -17.201 1.000 14.379  0  316 ALA A CA    1 ? 
ATOM   2503 C C     . ALA A 1 316 ? -14.252 9.821   -16.175 1.000 14.087  0  316 ALA A C     1 ? 
ATOM   2504 O O     . ALA A 1 316 ? -14.589 8.780   -15.565 1.000 14.154  0  316 ALA A O     1 ? 
ATOM   2505 C CB    . ALA A 1 316 ? -14.833 9.990   -18.592 1.000 14.286  0  316 ALA A CB    1 ? 
ATOM   2506 N N     . LEU A 1 317 ? -13.109 10.475  -15.972 1.000 11.908  0  317 LEU A N     1 ? 
ATOM   2507 C CA    . LEU A 1 317 ? -12.128 10.002  -14.978 1.000 11.787  0  317 LEU A CA    1 ? 
ATOM   2508 C C     . LEU A 1 317 ? -12.578 10.368  -13.556 1.000 10.236  0  317 LEU A C     1 ? 
ATOM   2509 O O     . LEU A 1 317 ? -12.289 9.613   -12.660 1.000 10.118  0  317 LEU A O     1 ? 
ATOM   2510 C CB    . LEU A 1 317 ? -10.770 10.591  -15.337 1.000 11.601  0  317 LEU A CB    1 ? 
ATOM   2511 C CG    . LEU A 1 317 ? -10.268 10.197  -16.714 1.000 13.358  0  317 LEU A CG    1 ? 
ATOM   2512 C CD1   . LEU A 1 317 ? -9.014  10.988  -17.075 1.000 15.575  0  317 LEU A CD1   1 ? 
ATOM   2513 C CD2   . LEU A 1 317 ? -10.034 8.693   -16.759 1.000 14.412  0  317 LEU A CD2   1 ? 
ATOM   2514 N N     . ALA A 1 318 ? -13.138 11.562  -13.325 1.000 10.670  0  318 ALA A N     1 ? 
ATOM   2515 C CA    . ALA A 1 318 ? -13.542 12.025  -11.974 1.000 10.935  0  318 ALA A CA    1 ? 
ATOM   2516 C C     . ALA A 1 318 ? -14.579 11.046  -11.410 1.000 11.481  0  318 ALA A C     1 ? 
ATOM   2517 O O     . ALA A 1 318 ? -14.626 10.845  -10.183 1.000 10.447  0  318 ALA A O     1 ? 
ATOM   2518 C CB    . ALA A 1 318 ? -14.071 13.429  -12.002 1.000 11.050  0  318 ALA A CB    1 ? 
ATOM   2519 N N     . ASP A 1 319 ? -15.360 10.417  -12.288 1.000 12.575  0  319 ASP A N     1 ? 
ATOM   2520 C CA    . ASP A 1 319 ? -16.366 9.399   -11.870 1.000 12.488  0  319 ASP A CA    1 ? 
ATOM   2521 C C     . ASP A 1 319 ? -15.702 8.225   -11.119 1.000 11.788  0  319 ASP A C     1 ? 
ATOM   2522 O O     . ASP A 1 319 ? -16.394 7.592   -10.327 1.000 10.754  0  319 ASP A O     1 ? 
ATOM   2523 C CB    . ASP A 1 319 ? -17.165 8.935   -13.082 1.000 15.034  0  319 ASP A CB    1 ? 
ATOM   2524 C CG    . ASP A 1 319 ? -18.113 10.019  -13.582 1.000 15.598  0  319 ASP A CG    1 ? 
ATOM   2525 O OD1   . ASP A 1 319 ? -18.578 9.889   -14.687 1.000 18.442  0  319 ASP A OD1   1 ? 
ATOM   2526 O OD2   . ASP A 1 319 ? -18.397 10.956  -12.825 1.000 18.628  0  319 ASP A OD2   1 ? 
ATOM   2527 N N     . HIS A 1 320 ? -14.415 7.930   -11.372 1.000 10.544  0  320 HIS A N     1 ? 
ATOM   2528 C CA    . HIS A 1 320 ? -13.662 6.800   -10.765 1.000 10.695  0  320 HIS A CA    1 ? 
ATOM   2529 C C     . HIS A 1 320 ? -12.670 7.285   -9.719  1.000 10.442  0  320 HIS A C     1 ? 
ATOM   2530 O O     . HIS A 1 320 ? -12.320 6.477   -8.847  1.000 11.015  0  320 HIS A O     1 ? 
ATOM   2531 C CB    . HIS A 1 320 ? -12.988 5.971   -11.854 1.000 11.161  0  320 HIS A CB    1 ? 
ATOM   2532 C CG    . HIS A 1 320 ? -13.984 5.461   -12.825 1.000 11.648  0  320 HIS A CG    1 ? 
ATOM   2533 N ND1   . HIS A 1 320 ? -14.629 4.301   -12.638 1.000 13.399  0  320 HIS A ND1   1 ? 
ATOM   2534 C CD2   . HIS A 1 320 ? -14.598 6.059   -13.861 1.000 12.387  0  320 HIS A CD2   1 ? 
ATOM   2535 C CE1   . HIS A 1 320 ? -15.548 4.152   -13.585 1.000 13.011  0  320 HIS A CE1   1 ? 
ATOM   2536 N NE2   . HIS A 1 320 ? -15.563 5.224   -14.319 1.000 11.986  0  320 HIS A NE2   1 ? 
ATOM   2537 N N     . PHE A 1 321 ? -12.181 8.537   -9.809  1.000 11.586  0  321 PHE A N     1 ? 
ATOM   2538 C CA    . PHE A 1 321 ? -11.091 9.057   -8.950  1.000 11.854  0  321 PHE A CA    1 ? 
ATOM   2539 C C     . PHE A 1 321 ? -11.597 9.997   -7.852  1.000 12.546  0  321 PHE A C     1 ? 
ATOM   2540 O O     . PHE A 1 321 ? -10.845 10.181  -6.868  1.000 13.933  0  321 PHE A O     1 ? 
ATOM   2541 C CB    . PHE A 1 321 ? -10.004 9.736   -9.777  1.000 12.880  0  321 PHE A CB    1 ? 
ATOM   2542 C CG    . PHE A 1 321 ? -9.166  8.774   -10.579 1.000 13.060  0  321 PHE A CG    1 ? 
ATOM   2543 C CD1   . PHE A 1 321 ? -8.498  7.708   -9.965  1.000 12.880  0  321 PHE A CD1   1 ? 
ATOM   2544 C CD2   . PHE A 1 321 ? -9.064  8.919   -11.943 1.000 13.373  0  321 PHE A CD2   1 ? 
ATOM   2545 C CE1   . PHE A 1 321 ? -7.756  6.815   -10.718 1.000 13.488  0  321 PHE A CE1   1 ? 
ATOM   2546 C CE2   . PHE A 1 321 ? -8.313  8.021   -12.699 1.000 14.443  0  321 PHE A CE2   1 ? 
ATOM   2547 C CZ    . PHE A 1 321 ? -7.650  6.990   -12.084 1.000 14.286  0  321 PHE A CZ    1 ? 
ATOM   2548 N N     . GLY A 1 322 ? -12.792 10.568  -8.006  1.000 13.004  0  322 GLY A N     1 ? 
ATOM   2549 C CA    . GLY A 1 322 ? -13.475 11.345  -6.960  1.000 12.492  0  322 GLY A CA    1 ? 
ATOM   2550 C C     . GLY A 1 322 ? -13.174 12.830  -7.116  1.000 12.726  0  322 GLY A C     1 ? 
ATOM   2551 O O     . GLY A 1 322 ? -12.716 13.247  -8.195  1.000 12.606  0  322 GLY A O     1 ? 
ATOM   2552 N N     . SER A 1 323 ? -13.353 13.574  -6.043  1.000 12.874  0  323 SER A N     1 ? 
ATOM   2553 C CA    . SER A 1 323 ? -13.535 15.034  -6.056  1.000 14.400  0  323 SER A CA    1 ? 
ATOM   2554 C C     . SER A 1 323 ? -12.216 15.776  -6.346  1.000 15.019  0  323 SER A C     1 ? 
ATOM   2555 O O     . SER A 1 323 ? -12.291 16.975  -6.725  1.000 14.301  0  323 SER A O     1 ? 
ATOM   2556 C CB    . SER A 1 323 ? -14.164 15.446  -4.763  1.000 15.599  0  323 SER A CB    1 ? 
ATOM   2557 O OG    . SER A 1 323 ? -13.226 15.298  -3.710  1.000 18.091  0  323 SER A OG    1 ? 
ATOM   2558 N N     . GLU A 1 324 ? -11.053 15.136  -6.208  1.000 13.010  0  324 GLU A N     1 ? 
ATOM   2559 C CA    . GLU A 1 324 ? -9.741  15.816  -6.401  1.000 13.913  0  324 GLU A CA    1 ? 
ATOM   2560 C C     . GLU A 1 324 ? -9.335  15.802  -7.863  1.000 13.142  0  324 GLU A C     1 ? 
ATOM   2561 O O     . GLU A 1 324 ? -8.359  16.492  -8.199  1.000 14.310  0  324 GLU A O     1 ? 
ATOM   2562 C CB    . GLU A 1 324 ? -8.645  15.156  -5.587  1.000 14.969  0  324 GLU A CB    1 ? 
ATOM   2563 C CG    . GLU A 1 324 ? -8.829  15.348  -4.104  1.000 17.288  0  324 GLU A CG    1 ? 
ATOM   2564 C CD    . GLU A 1 324 ? -8.763  16.793  -3.611  1.000 20.171  0  324 GLU A CD    1 ? 
ATOM   2565 O OE1   . GLU A 1 324 ? -9.098  17.002  -2.429  1.000 22.158  0  324 GLU A OE1   1 ? 
ATOM   2566 O OE2   . GLU A 1 324 ? -8.330  17.712  -4.397  1.000 21.213  0  324 GLU A OE2   1 ? 
ATOM   2567 N N     . PHE A 1 325 ? -10.003 15.013  -8.711  1.000 11.745  0  325 PHE A N     1 ? 
ATOM   2568 C CA    . PHE A 1 325 ? -9.661  14.970  -10.138 1.000 10.980  0  325 PHE A CA    1 ? 
ATOM   2569 C C     . PHE A 1 325 ? -10.219 16.219  -10.812 1.000 11.485  0  325 PHE A C     1 ? 
ATOM   2570 O O     . PHE A 1 325 ? -11.430 16.392  -10.862 1.000 10.950  0  325 PHE A O     1 ? 
ATOM   2571 C CB    . PHE A 1 325 ? -10.134 13.704  -10.837 1.000 10.983  0  325 PHE A CB    1 ? 
ATOM   2572 C CG    . PHE A 1 325 ? -9.395  13.493  -12.123 1.000 11.232  0  325 PHE A CG    1 ? 
ATOM   2573 C CD1   . PHE A 1 325 ? -9.725  14.203  -13.260 1.000 11.355  0  325 PHE A CD1   1 ? 
ATOM   2574 C CD2   . PHE A 1 325 ? -8.306  12.628  -12.176 1.000 11.926  0  325 PHE A CD2   1 ? 
ATOM   2575 C CE1   . PHE A 1 325 ? -8.994  14.039  -14.432 1.000 12.026  0  325 PHE A CE1   1 ? 
ATOM   2576 C CE2   . PHE A 1 325 ? -7.590  12.456  -13.349 1.000 11.058  0  325 PHE A CE2   1 ? 
ATOM   2577 C CZ    . PHE A 1 325 ? -7.933  13.153  -14.467 1.000 12.065  0  325 PHE A CZ    1 ? 
ATOM   2578 N N     . PRO A 1 326 ? -9.355  17.104  -11.381 1.000 12.876  0  326 PRO A N     1 ? 
ATOM   2579 C CA    . PRO A 1 326 ? -9.813  18.367  -11.970 1.000 13.266  0  326 PRO A CA    1 ? 
ATOM   2580 C C     . PRO A 1 326 ? -10.721 18.128  -13.170 1.000 12.946  0  326 PRO A C     1 ? 
ATOM   2581 O O     . PRO A 1 326 ? -10.404 17.324  -14.011 1.000 12.791  0  326 PRO A O     1 ? 
ATOM   2582 C CB    . PRO A 1 326 ? -8.520  19.094  -12.390 1.000 13.170  0  326 PRO A CB    1 ? 
ATOM   2583 C CG    . PRO A 1 326 ? -7.480  18.469  -11.513 1.000 13.541  0  326 PRO A CG    1 ? 
ATOM   2584 C CD    . PRO A 1 326 ? -7.892  17.006  -11.452 1.000 12.659  0  326 PRO A CD    1 ? 
ATOM   2585 N N     . VAL A 1 327 ? -11.837 18.851  -13.217 1.000 13.784  0  327 VAL A N     1 ? 
ATOM   2586 C CA    . VAL A 1 327 ? -12.753 18.830  -14.373 1.000 14.864  0  327 VAL A CA    1 ? 
ATOM   2587 C C     . VAL A 1 327 ? -12.893 20.243  -14.955 1.000 15.876  0  327 VAL A C     1 ? 
ATOM   2588 O O     . VAL A 1 327 ? -13.684 21.052  -14.471 1.000 14.465  0  327 VAL A O     1 ? 
ATOM   2589 C CB    . VAL A 1 327 ? -14.103 18.227  -13.964 1.000 15.765  0  327 VAL A CB    1 ? 
ATOM   2590 C CG1   . VAL A 1 327 ? -15.049 18.198  -15.160 1.000 17.016  0  327 VAL A CG1   1 ? 
ATOM   2591 C CG2   . VAL A 1 327 ? -13.924 16.854  -13.358 1.000 15.992  0  327 VAL A CG2   1 ? 
ATOM   2592 N N     . PRO A 1 328 ? -12.120 20.587  -16.006 1.000 17.968  0  328 PRO A N     1 ? 
ATOM   2593 C CA    . PRO A 1 328 ? -12.216 21.906  -16.622 1.000 20.507  0  328 PRO A CA    1 ? 
ATOM   2594 C C     . PRO A 1 328 ? -13.627 22.146  -17.174 1.000 23.457  0  328 PRO A C     1 ? 
ATOM   2595 O O     . PRO A 1 328 ? -14.248 21.170  -17.636 1.000 18.149  0  328 PRO A O     1 ? 
ATOM   2596 C CB    . PRO A 1 328 ? -11.174 21.829  -17.731 1.000 20.464  0  328 PRO A CB    1 ? 
ATOM   2597 C CG    . PRO A 1 328 ? -10.184 20.815  -17.217 1.000 21.037  0  328 PRO A CG    1 ? 
ATOM   2598 C CD    . PRO A 1 328 ? -11.079 19.758  -16.623 1.000 19.304  0  328 PRO A CD    1 ? 
ATOM   2599 N N     . GLU A 1 329 ? -14.118 23.390  -17.043 1.000 26.586  0  329 GLU A N     1 ? 
ATOM   2600 C CA    . GLU A 1 329 ? -15.459 23.817  -17.534 1.000 34.855  0  329 GLU A CA    1 ? 
ATOM   2601 C C     . GLU A 1 329 ? -15.491 23.697  -19.068 1.000 32.167  0  329 GLU A C     1 ? 
ATOM   2602 O O     . GLU A 1 329 ? -14.449 23.898  -19.677 1.000 35.734  0  329 GLU A O     1 ? 
ATOM   2603 C CB    . GLU A 1 329 ? -15.776 25.241  -17.061 1.000 40.426  0  329 GLU A CB    1 ? 
ATOM   2604 C CG    . GLU A 1 329 ? -17.280 25.531  -17.021 1.000 50.355  0  329 GLU A CG    1 ? 
ATOM   2605 C CD    . GLU A 1 329 ? -17.719 26.985  -17.211 1.000 56.763  0  329 GLU A CD    1 ? 
ATOM   2606 O OE1   . GLU A 1 329 ? -17.252 27.867  -16.429 1.000 57.009  0  329 GLU A OE1   1 ? 
ATOM   2607 O OE2   . GLU A 1 329 ? -18.543 27.238  -18.137 1.000 53.029  0  329 GLU A OE2   1 ? 
ATOM   2608 N N     . LYS A 1 330 ? -16.645 23.378  -19.666 1.000 35.281  0  330 LYS A N     1 ? 
ATOM   2609 C CA    . LYS A 1 330 ? -16.780 23.131  -21.133 1.000 41.002  0  330 LYS A CA    1 ? 
ATOM   2610 C C     . LYS A 1 330 ? -16.821 24.463  -21.895 1.000 43.161  0  330 LYS A C     1 ? 
ATOM   2611 O O     . LYS A 1 330 ? -17.269 25.466  -21.350 1.000 43.757  0  330 LYS A O     1 ? 
ATOM   2612 C CB    . LYS A 1 330 ? -18.025 22.295  -21.456 1.000 48.826  0  330 LYS A CB    1 ? 
ATOM   2613 C CG    . LYS A 1 330 ? -18.244 22.079  -22.948 1.000 55.243  0  330 LYS A CG    1 ? 
ATOM   2614 C CD    . LYS A 1 330 ? -19.260 21.025  -23.315 1.000 61.107  0  330 LYS A CD    1 ? 
ATOM   2615 C CE    . LYS A 1 330 ? -19.585 21.060  -24.799 1.000 66.581  0  330 LYS A CE    1 ? 
ATOM   2616 N NZ    . LYS A 1 330 ? -20.719 20.172  -25.156 1.000 70.287  0  330 LYS A NZ    1 ? 
HETATM 2617 P PA    . 2KH B 2 .   ? -3.222  -7.351  9.607   1.000 101.193 0  401 2KH A PA    1 ? 
HETATM 2618 O O1A   . 2KH B 2 .   ? -2.268  -7.166  10.765  1.000 81.191  0  401 2KH A O1A   1 ? 
HETATM 2619 O O2A   . 2KH B 2 .   ? -2.939  -8.675  8.939   1.000 91.805  -1 401 2KH A O2A   1 ? 
HETATM 2620 N N3A   . 2KH B 2 .   ? -4.864  -7.267  10.153  1.000 111.145 0  401 2KH A N3A   1 ? 
HETATM 2621 O "O5'" . 2KH B 2 .   ? -2.973  -6.132  8.513   1.000 99.658  0  401 2KH A "O5'" 1 ? 
HETATM 2622 P PB    . 2KH B 2 .   ? -5.844  -8.595  10.661  1.000 122.886 0  401 2KH A PB    1 ? 
HETATM 2623 O O1B   . 2KH B 2 .   ? -5.318  -9.878  10.065  1.000 133.314 0  401 2KH A O1B   1 ? 
HETATM 2624 O O2B   . 2KH B 2 .   ? -5.815  -8.692  12.172  1.000 107.818 -1 401 2KH A O2B   1 ? 
HETATM 2625 O O3B   . 2KH B 2 .   ? -7.425  -8.402  10.153  1.000 138.926 0  401 2KH A O3B   1 ? 
HETATM 2626 P PG    . 2KH B 2 .   ? -8.643  -9.547  10.105  1.000 150.108 0  401 2KH A PG    1 ? 
HETATM 2627 O O1G   . 2KH B 2 .   ? -9.682  -9.209  11.151  1.000 145.645 0  401 2KH A O1G   1 ? 
HETATM 2628 O O2G   . 2KH B 2 .   ? -9.314  -9.546  8.743   1.000 137.799 -1 401 2KH A O2G   1 ? 
HETATM 2629 O O3G   . 2KH B 2 .   ? -8.097  -10.931 10.393  1.000 145.492 -1 401 2KH A O3G   1 ? 
HETATM 2630 C "C5'" . 2KH B 2 .   ? -1.693  -5.937  7.966   1.000 98.364  0  401 2KH A "C5'" 1 ? 
HETATM 2631 C "C4'" . 2KH B 2 .   ? -0.987  -4.971  8.732   1.000 95.561  0  401 2KH A "C4'" 1 ? 
HETATM 2632 O "O4'" . 2KH B 2 .   ? 0.322   -5.552  9.208   1.000 91.196  0  401 2KH A "O4'" 1 ? 
HETATM 2633 C "C1'" . 2KH B 2 .   ? 1.190   -4.604  9.115   1.000 83.583  0  401 2KH A "C1'" 1 ? 
HETATM 2634 C "C2'" . 2KH B 2 .   ? 0.644   -3.603  7.921   1.000 90.673  0  401 2KH A "C2'" 1 ? 
HETATM 2635 O "O2'" . 2KH B 2 .   ? 1.092   -2.192  8.151   1.000 90.825  0  401 2KH A "O2'" 1 ? 
HETATM 2636 C "C3'" . 2KH B 2 .   ? -0.600  -3.707  7.860   1.000 92.961  0  401 2KH A "C3'" 1 ? 
HETATM 2637 O "O3'" . 2KH B 2 .   ? -1.275  -2.441  8.359   1.000 93.604  0  401 2KH A "O3'" 1 ? 
HETATM 2638 N N1    . 2KH B 2 .   ? 2.497   -5.105  8.715   1.000 75.088  0  401 2KH A N1    1 ? 
HETATM 2639 C C6    . 2KH B 2 .   ? 2.616   -6.356  8.249   1.000 64.270  0  401 2KH A C6    1 ? 
HETATM 2640 C C2    . 2KH B 2 .   ? 3.561   -4.291  8.759   1.000 74.717  0  401 2KH A C2    1 ? 
HETATM 2641 O O2    . 2KH B 2 .   ? 3.455   -3.148  9.164   1.000 71.883  0  401 2KH A O2    1 ? 
HETATM 2642 N N3    . 2KH B 2 .   ? 4.766   -4.755  8.357   1.000 72.714  0  401 2KH A N3    1 ? 
HETATM 2643 C C4    . 2KH B 2 .   ? 4.973   -6.007  7.899   1.000 64.163  0  401 2KH A C4    1 ? 
HETATM 2644 O O4    . 2KH B 2 .   ? 6.086   -6.382  7.535   1.000 49.458  0  401 2KH A O4    1 ? 
HETATM 2645 C C5    . 2KH B 2 .   ? 3.857   -6.846  7.826   1.000 58.451  0  401 2KH A C5    1 ? 
HETATM 2646 P PA    . 2KH C 2 .   ? 1.273   -1.837  4.705   1.000 95.857  0  402 2KH A PA    1 ? 
HETATM 2647 O O1A   . 2KH C 2 .   ? 0.540   -0.729  5.450   1.000 91.702  0  402 2KH A O1A   1 ? 
HETATM 2648 O O2A   . 2KH C 2 .   ? 0.428   -3.092  4.743   1.000 94.181  -1 402 2KH A O2A   1 ? 
HETATM 2649 N N3A   . 2KH C 2 .   ? 1.474   -1.416  3.046   1.000 87.363  0  402 2KH A N3A   1 ? 
HETATM 2650 O "O5'" . 2KH C 2 .   ? 2.763   -2.123  5.389   1.000 88.949  0  402 2KH A "O5'" 1 ? 
HETATM 2651 P PB    . 2KH C 2 .   ? 1.311   0.174   2.411   1.000 65.897  0  402 2KH A PB    1 ? 
HETATM 2652 O O1B   . 2KH C 2 .   ? 1.648   1.188   3.498   1.000 47.673  0  402 2KH A O1B   1 ? 
HETATM 2653 O O2B   . 2KH C 2 .   ? 2.253   0.241   1.196   1.000 64.711  -1 402 2KH A O2B   1 ? 
HETATM 2654 O O3B   . 2KH C 2 .   ? -0.257  0.458   1.902   1.000 69.170  0  402 2KH A O3B   1 ? 
HETATM 2655 P PG    . 2KH C 2 .   ? -1.138  1.884   2.074   1.000 68.522  0  402 2KH A PG    1 ? 
HETATM 2656 O O1G   . 2KH C 2 .   ? -2.567  1.699   1.539   1.000 61.047  0  402 2KH A O1G   1 ? 
HETATM 2657 O O2G   . 2KH C 2 .   ? -0.528  3.039   1.303   1.000 67.278  -1 402 2KH A O2G   1 ? 
HETATM 2658 O O3G   . 2KH C 2 .   ? -1.127  2.276   3.553   1.000 66.006  -1 402 2KH A O3G   1 ? 
HETATM 2659 C "C5'" . 2KH C 2 .   ? 3.887   -1.939  4.564   1.000 80.976  0  402 2KH A "C5'" 1 ? 
HETATM 2660 C "C4'" . 2KH C 2 .   ? 4.978   -2.730  4.989   1.000 70.143  0  402 2KH A "C4'" 1 ? 
HETATM 2661 O "O4'" . 2KH C 2 .   ? 4.469   -4.105  5.373   1.000 71.156  0  402 2KH A "O4'" 1 ? 
HETATM 2662 C "C1'" . 2KH C 2 .   ? 5.115   -4.978  4.673   1.000 68.522  0  402 2KH A "C1'" 1 ? 
HETATM 2663 C "C2'" . 2KH C 2 .   ? 5.999   -4.151  3.525   1.000 59.133  0  402 2KH A "C2'" 1 ? 
HETATM 2664 O "O2'" . 2KH C 2 .   ? 7.344   -4.737  3.478   1.000 73.588  0  402 2KH A "O2'" 1 ? 
HETATM 2665 C "C3'" . 2KH C 2 .   ? 6.035   -2.910  3.815   1.000 58.021  0  402 2KH A "C3'" 1 ? 
HETATM 2666 O "O3'" . 2KH C 2 .   ? 7.425   -2.242  4.134   1.000 35.137  0  402 2KH A "O3'" 1 ? 
HETATM 2667 N N1    . 2KH C 2 .   ? 4.203   -6.042  4.187   1.000 72.871  0  402 2KH A N1    1 ? 
HETATM 2668 C C6    . 2KH C 2 .   ? 4.716   -7.053  3.484   1.000 71.100  0  402 2KH A C6    1 ? 
HETATM 2669 C C2    . 2KH C 2 .   ? 2.872   -6.050  4.483   1.000 76.084  0  402 2KH A C2    1 ? 
HETATM 2670 O O2    . 2KH C 2 .   ? 2.375   -5.179  5.126   1.000 73.639  0  402 2KH A O2    1 ? 
HETATM 2671 N N3    . 2KH C 2 .   ? 2.058   -7.025  4.053   1.000 76.296  0  402 2KH A N3    1 ? 
HETATM 2672 C C4    . 2KH C 2 .   ? 2.520   -8.041  3.333   1.000 68.389  0  402 2KH A C4    1 ? 
HETATM 2673 O O4    . 2KH C 2 .   ? 1.786   -8.901  2.946   1.000 61.915  0  402 2KH A O4    1 ? 
HETATM 2674 C C5    . 2KH C 2 .   ? 3.878   -8.073  3.033   1.000 68.256  0  402 2KH A C5    1 ? 
HETATM 2675 O O     . HOH D 3 .   ? -7.791  -2.797  -23.605 1.000 28.489  0  501 HOH A O     1 ? 
HETATM 2676 O O     . HOH D 3 .   ? 19.350  -3.970  -3.981  1.000 20.313  0  502 HOH A O     1 ? 
HETATM 2677 O O     . HOH D 3 .   ? 2.627   1.071   -0.977  1.000 17.919  0  503 HOH A O     1 ? 
HETATM 2678 O O     . HOH D 3 .   ? 15.485  -13.767 23.843  1.000 34.066  0  504 HOH A O     1 ? 
HETATM 2679 O O     . HOH D 3 .   ? 12.825  2.313   2.108   1.000 36.603  0  505 HOH A O     1 ? 
HETATM 2680 O O     . HOH D 3 .   ? 12.046  3.591   -19.421 1.000 46.478  0  506 HOH A O     1 ? 
HETATM 2681 O O     . HOH D 3 .   ? 12.847  -2.923  -13.658 1.000 37.708  0  507 HOH A O     1 ? 
HETATM 2682 O O     . HOH D 3 .   ? -9.231  -4.349  2.356   1.000 33.784  0  508 HOH A O     1 ? 
HETATM 2683 O O     . HOH D 3 .   ? 3.160   -10.975 3.347   1.000 27.627  0  509 HOH A O     1 ? 
HETATM 2684 O O     . HOH D 3 .   ? 16.658  3.340   -14.945 1.000 24.589  0  510 HOH A O     1 ? 
HETATM 2685 O O     . HOH D 3 .   ? -6.137  -13.886 -4.949  1.000 18.894  0  511 HOH A O     1 ? 
HETATM 2686 O O     . HOH D 3 .   ? 11.914  13.411  -18.068 1.000 26.225  0  512 HOH A O     1 ? 
HETATM 2687 O O     . HOH D 3 .   ? -16.466 15.460  -25.843 1.000 37.565  0  513 HOH A O     1 ? 
HETATM 2688 O O     . HOH D 3 .   ? 16.381  0.984   -11.628 1.000 31.006  0  514 HOH A O     1 ? 
HETATM 2689 O O     . HOH D 3 .   ? 6.157   -12.890 6.574   1.000 34.498  0  515 HOH A O     1 ? 
HETATM 2690 O O     . HOH D 3 .   ? -5.394  -10.442 1.320   1.000 22.867  0  516 HOH A O     1 ? 
HETATM 2691 O O     . HOH D 3 .   ? -22.197 -12.883 -8.906  1.000 20.520  0  517 HOH A O     1 ? 
HETATM 2692 O O     . HOH D 3 .   ? -1.639  -14.493 -13.945 1.000 28.772  0  518 HOH A O     1 ? 
HETATM 2693 O O     . HOH D 3 .   ? -4.089  -17.211 -3.420  1.000 33.530  0  519 HOH A O     1 ? 
HETATM 2694 O O     . HOH D 3 .   ? -5.825  6.052   2.275   1.000 32.260  0  520 HOH A O     1 ? 
HETATM 2695 O O     . HOH D 3 .   ? 6.688   -8.888  -14.458 1.000 29.070  0  521 HOH A O     1 ? 
HETATM 2696 O O     . HOH D 3 .   ? -12.700 4.475   1.567   1.000 23.873  0  522 HOH A O     1 ? 
HETATM 2697 O O     . HOH D 3 .   ? -9.331  13.231  -24.714 1.000 24.879  0  523 HOH A O     1 ? 
HETATM 2698 O O     . HOH D 3 .   ? -4.767  17.934  -1.256  1.000 21.441  0  524 HOH A O     1 ? 
HETATM 2699 O O     . HOH D 3 .   ? -16.947 3.699   -2.508  1.000 33.447  0  525 HOH A O     1 ? 
HETATM 2700 O O     . HOH D 3 .   ? -9.414  14.726  -1.240  1.000 28.846  0  526 HOH A O     1 ? 
HETATM 2701 O O     . HOH D 3 .   ? -18.872 7.946   -9.665  1.000 16.035  0  527 HOH A O     1 ? 
HETATM 2702 O O     . HOH D 3 .   ? -4.205  25.645  -14.766 1.000 33.561  0  528 HOH A O     1 ? 
HETATM 2703 O O     . HOH D 3 .   ? -3.654  -14.056 -11.199 1.000 20.056  0  529 HOH A O     1 ? 
HETATM 2704 O O     . HOH D 3 .   ? -2.943  -13.040 3.654   1.000 48.540  0  530 HOH A O     1 ? 
HETATM 2705 O O     . HOH D 3 .   ? -3.778  24.187  -12.025 1.000 34.501  0  531 HOH A O     1 ? 
HETATM 2706 O O     . HOH D 3 .   ? 16.205  -19.899 15.481  1.000 38.804  0  532 HOH A O     1 ? 
HETATM 2707 O O     . HOH D 3 .   ? -21.369 -17.258 -1.654  1.000 27.905  0  533 HOH A O     1 ? 
HETATM 2708 O O     . HOH D 3 .   ? 12.250  8.921   -9.113  1.000 18.150  0  534 HOH A O     1 ? 
HETATM 2709 O O     . HOH D 3 .   ? -13.578 15.808  -9.510  1.000 13.389  0  535 HOH A O     1 ? 
HETATM 2710 O O     . HOH D 3 .   ? 14.129  -12.799 13.109  1.000 22.275  0  536 HOH A O     1 ? 
HETATM 2711 O O     . HOH D 3 .   ? -13.951 -5.820  -4.068  1.000 14.772  0  537 HOH A O     1 ? 
HETATM 2712 O O     . HOH D 3 .   ? -2.528  8.373   -25.070 1.000 20.342  0  538 HOH A O     1 ? 
HETATM 2713 O O     . HOH D 3 .   ? 5.971   -10.067 6.045   1.000 37.506  0  539 HOH A O     1 ? 
HETATM 2714 O O     . HOH D 3 .   ? -13.744 -7.544  -17.294 1.000 25.995  0  540 HOH A O     1 ? 
HETATM 2715 O O     . HOH D 3 .   ? 14.364  -11.738 5.235   1.000 37.393  0  541 HOH A O     1 ? 
HETATM 2716 O O     . HOH D 3 .   ? 7.388   12.424  -0.902  1.000 16.586  0  542 HOH A O     1 ? 
HETATM 2717 O O     . HOH D 3 .   ? -19.712 -19.987 0.202   1.000 39.540  0  543 HOH A O     1 ? 
HETATM 2718 O O     . HOH D 3 .   ? 1.676   0.676   -17.746 1.000 11.723  0  544 HOH A O     1 ? 
HETATM 2719 O O     . HOH D 3 .   ? 15.935  -9.360  -0.367  1.000 30.194  0  545 HOH A O     1 ? 
HETATM 2720 O O     . HOH D 3 .   ? -9.742  5.196   -26.525 1.000 28.251  0  546 HOH A O     1 ? 
HETATM 2721 O O     . HOH D 3 .   ? -20.749 11.308  -15.136 1.000 19.354  0  547 HOH A O     1 ? 
HETATM 2722 O O     . HOH D 3 .   ? -7.362  14.170  3.694   1.000 39.185  0  548 HOH A O     1 ? 
HETATM 2723 O O     . HOH D 3 .   ? -6.922  21.704  -15.067 1.000 22.920  0  549 HOH A O     1 ? 
HETATM 2724 O O     . HOH D 3 .   ? -11.412 -14.607 3.302   1.000 40.568  0  550 HOH A O     1 ? 
HETATM 2725 O O     . HOH D 3 .   ? -15.050 -12.076 -15.755 1.000 47.230  0  551 HOH A O     1 ? 
HETATM 2726 O O     . HOH D 3 .   ? -20.605 -29.944 -10.031 1.000 26.581  0  552 HOH A O     1 ? 
HETATM 2727 O O     . HOH D 3 .   ? 9.937   3.779   -4.062  1.000 13.584  0  553 HOH A O     1 ? 
HETATM 2728 O O     . HOH D 3 .   ? 7.794   -9.590  3.611   1.000 17.652  0  554 HOH A O     1 ? 
HETATM 2729 O O     . HOH D 3 .   ? -6.987  -18.600 -9.443  1.000 22.052  0  555 HOH A O     1 ? 
HETATM 2730 O O     . HOH D 3 .   ? -7.274  18.847  -1.864  1.000 35.587  0  556 HOH A O     1 ? 
HETATM 2731 O O     . HOH D 3 .   ? -3.975  4.391   -24.924 1.000 21.211  0  557 HOH A O     1 ? 
HETATM 2732 O O     . HOH D 3 .   ? -4.990  18.366  -20.691 1.000 19.452  0  558 HOH A O     1 ? 
HETATM 2733 O O     . HOH D 3 .   ? -13.352 -22.180 -13.623 1.000 45.404  0  559 HOH A O     1 ? 
HETATM 2734 O O     . HOH D 3 .   ? 1.617   9.404   -25.373 1.000 22.268  0  560 HOH A O     1 ? 
HETATM 2735 O O     . HOH D 3 .   ? -15.487 -23.859 -1.715  1.000 33.324  0  561 HOH A O     1 ? 
HETATM 2736 O O     . HOH D 3 .   ? -16.588 7.444   -1.936  1.000 27.239  0  562 HOH A O     1 ? 
HETATM 2737 O O     . HOH D 3 .   ? 16.796  -6.169  -1.930  1.000 45.643  0  563 HOH A O     1 ? 
HETATM 2738 O O     . HOH D 3 .   ? -1.225  16.777  -1.408  1.000 20.338  0  564 HOH A O     1 ? 
HETATM 2739 O O     . HOH D 3 .   ? 7.255   0.987   -21.492 1.000 35.011  0  565 HOH A O     1 ? 
HETATM 2740 O O     . HOH D 3 .   ? -16.300 21.416  -14.034 1.000 27.997  0  566 HOH A O     1 ? 
HETATM 2741 O O     . HOH D 3 .   ? -16.431 -9.125  -12.831 1.000 23.001  0  567 HOH A O     1 ? 
HETATM 2742 O O     . HOH D 3 .   ? 13.073  -12.235 0.574   1.000 18.925  0  568 HOH A O     1 ? 
HETATM 2743 O O     . HOH D 3 .   ? -18.402 1.757   -5.250  1.000 26.457  0  569 HOH A O     1 ? 
HETATM 2744 O O     . HOH D 3 .   ? 10.751  2.014   -1.927  1.000 16.502  0  570 HOH A O     1 ? 
HETATM 2745 O O     . HOH D 3 .   ? -17.530 -22.192 -13.754 1.000 24.315  0  571 HOH A O     1 ? 
HETATM 2746 O O     . HOH D 3 .   ? 8.415   -18.729 2.781   1.000 37.627  0  572 HOH A O     1 ? 
HETATM 2747 O O     . HOH D 3 .   ? 6.655   -4.406  -15.277 1.000 20.218  0  573 HOH A O     1 ? 
HETATM 2748 O O     . HOH D 3 .   ? -3.476  10.556  -22.825 1.000 19.612  0  574 HOH A O     1 ? 
HETATM 2749 O O     . HOH D 3 .   ? 1.552   3.589   5.258   1.000 22.128  0  575 HOH A O     1 ? 
HETATM 2750 O O     . HOH D 3 .   ? 4.739   9.300   -0.102  1.000 17.015  0  576 HOH A O     1 ? 
HETATM 2751 O O     . HOH D 3 .   ? -17.927 -11.806 0.152   1.000 21.483  0  577 HOH A O     1 ? 
HETATM 2752 O O     . HOH D 3 .   ? -10.423 12.258  -5.146  1.000 11.018  0  578 HOH A O     1 ? 
HETATM 2753 O O     . HOH D 3 .   ? 2.699   14.582  -21.845 1.000 31.136  0  579 HOH A O     1 ? 
HETATM 2754 O O     . HOH D 3 .   ? 1.319   -2.100  -18.086 1.000 13.142  0  580 HOH A O     1 ? 
HETATM 2755 O O     . HOH D 3 .   ? -17.749 -2.945  -15.212 1.000 27.242  0  581 HOH A O     1 ? 
HETATM 2756 O O     . HOH D 3 .   ? -11.480 -13.917 -14.781 1.000 19.657  0  582 HOH A O     1 ? 
HETATM 2757 O O     . HOH D 3 .   ? 11.263  2.402   -9.018  1.000 15.152  0  583 HOH A O     1 ? 
HETATM 2758 O O     . HOH D 3 .   ? 10.775  -12.002 -7.067  1.000 23.895  0  584 HOH A O     1 ? 
HETATM 2759 O O     . HOH D 3 .   ? -14.133 1.863   -11.126 1.000 11.417  0  585 HOH A O     1 ? 
HETATM 2760 O O     . HOH D 3 .   ? -17.512 -20.695 -0.838  1.000 41.174  0  586 HOH A O     1 ? 
HETATM 2761 O O     . HOH D 3 .   ? 8.336   -1.088  -15.964 1.000 24.213  0  587 HOH A O     1 ? 
HETATM 2762 O O     . HOH D 3 .   ? -0.329  -17.210 -0.800  1.000 23.593  0  588 HOH A O     1 ? 
HETATM 2763 O O     . HOH D 3 .   ? 9.088   8.691   -28.547 1.000 40.096  0  589 HOH A O     1 ? 
HETATM 2764 O O     . HOH D 3 .   ? 10.232  -2.988  -15.239 1.000 39.181  0  590 HOH A O     1 ? 
HETATM 2765 O O     . HOH D 3 .   ? -6.334  -16.610 -5.874  1.000 30.884  0  591 HOH A O     1 ? 
HETATM 2766 O O     . HOH D 3 .   ? -6.969  -6.781  -0.367  1.000 37.470  0  592 HOH A O     1 ? 
HETATM 2767 O O     . HOH D 3 .   ? 13.314  5.198   -6.878  1.000 28.415  0  593 HOH A O     1 ? 
HETATM 2768 O O     . HOH D 3 .   ? -2.204  11.506  -19.505 1.000 13.274  0  594 HOH A O     1 ? 
HETATM 2769 O O     . HOH D 3 .   ? 17.650  -5.250  18.084  1.000 42.112  0  595 HOH A O     1 ? 
HETATM 2770 O O     . HOH D 3 .   ? -16.620 7.059   -16.361 1.000 19.160  0  596 HOH A O     1 ? 
HETATM 2771 O O     . HOH D 3 .   ? 4.209   4.099   6.126   1.000 17.984  0  597 HOH A O     1 ? 
HETATM 2772 O O     . HOH D 3 .   ? 16.561  -2.851  -10.888 1.000 32.908  0  598 HOH A O     1 ? 
HETATM 2773 O O     . HOH D 3 .   ? -11.161 -23.152 -11.723 1.000 23.371  0  599 HOH A O     1 ? 
HETATM 2774 O O     . HOH D 3 .   ? -16.768 3.267   -17.148 1.000 17.755  0  600 HOH A O     1 ? 
HETATM 2775 O O     . HOH D 3 .   ? 12.953  14.105  12.273  1.000 40.798  0  601 HOH A O     1 ? 
HETATM 2776 O O     . HOH D 3 .   ? -17.874 12.287  -19.594 1.000 23.941  0  602 HOH A O     1 ? 
HETATM 2777 O O     . HOH D 3 .   ? 11.702  6.574   -0.824  1.000 36.265  0  603 HOH A O     1 ? 
HETATM 2778 O O     . HOH D 3 .   ? -18.233 1.093   -2.291  1.000 23.260  0  604 HOH A O     1 ? 
HETATM 2779 O O     . HOH D 3 .   ? -20.907 17.084  -17.819 1.000 39.949  0  605 HOH A O     1 ? 
HETATM 2780 O O     . HOH D 3 .   ? 8.445   18.264  6.433   1.000 37.142  0  606 HOH A O     1 ? 
HETATM 2781 O O     . HOH D 3 .   ? -5.703  -16.308 -9.779  1.000 22.589  0  607 HOH A O     1 ? 
HETATM 2782 O O     . HOH D 3 .   ? 8.523   -18.522 7.938   1.000 38.229  0  608 HOH A O     1 ? 
HETATM 2783 O O     . HOH D 3 .   ? -6.521  14.551  -1.139  1.000 17.092  0  609 HOH A O     1 ? 
HETATM 2784 O O     . HOH D 3 .   ? -4.746  -0.752  2.043   1.000 31.438  0  610 HOH A O     1 ? 
HETATM 2785 O O     . HOH D 3 .   ? 9.008   13.088  -3.598  1.000 32.408  0  611 HOH A O     1 ? 
HETATM 2786 O O     . HOH D 3 .   ? 3.356   -5.450  -18.095 1.000 25.770  0  612 HOH A O     1 ? 
HETATM 2787 O O     . HOH D 3 .   ? 7.231   11.368  -14.612 1.000 13.677  0  613 HOH A O     1 ? 
HETATM 2788 O O     . HOH D 3 .   ? 8.560   0.584   -18.231 1.000 18.253  0  614 HOH A O     1 ? 
HETATM 2789 O O     . HOH D 3 .   ? 2.094   15.759  -10.145 1.000 13.276  0  615 HOH A O     1 ? 
HETATM 2790 O O     . HOH D 3 .   ? 11.300  8.612   3.387   1.000 22.871  0  616 HOH A O     1 ? 
HETATM 2791 O O     . HOH D 3 .   ? -8.414  20.513  -4.696  1.000 18.887  0  617 HOH A O     1 ? 
HETATM 2792 O O     . HOH D 3 .   ? -9.537  7.381   3.006   1.000 33.743  0  618 HOH A O     1 ? 
HETATM 2793 O O     . HOH D 3 .   ? -12.173 -10.017 2.829   1.000 33.443  0  619 HOH A O     1 ? 
HETATM 2794 O O     . HOH D 3 .   ? -3.610  4.409   1.889   1.000 38.623  0  620 HOH A O     1 ? 
HETATM 2795 O O     . HOH D 3 .   ? -0.931  5.807   1.738   1.000 18.079  0  621 HOH A O     1 ? 
HETATM 2796 O O     . HOH D 3 .   ? 2.433   16.000  1.717   1.000 29.575  0  622 HOH A O     1 ? 
HETATM 2797 O O     . HOH D 3 .   ? -10.610 -6.758  -19.966 1.000 21.133  0  623 HOH A O     1 ? 
HETATM 2798 O O     . HOH D 3 .   ? -2.505  -6.263  -22.042 1.000 44.237  0  624 HOH A O     1 ? 
HETATM 2799 O O     . HOH D 3 .   ? 6.240   -9.123  32.763  1.000 44.054  0  625 HOH A O     1 ? 
HETATM 2800 O O     . HOH D 3 .   ? 9.553   -19.615 19.220  1.000 37.318  0  626 HOH A O     1 ? 
HETATM 2801 O O     . HOH D 3 .   ? 1.245   19.647  -11.675 1.000 27.036  0  627 HOH A O     1 ? 
HETATM 2802 O O     . HOH D 3 .   ? 13.288  9.399   -21.138 1.000 31.091  0  628 HOH A O     1 ? 
HETATM 2803 O O     . HOH D 3 .   ? 18.478  -6.139  24.617  1.000 37.801  0  629 HOH A O     1 ? 
HETATM 2804 O O     . HOH D 3 .   ? -9.911  -17.660 -16.475 1.000 35.693  0  630 HOH A O     1 ? 
HETATM 2805 O O     . HOH D 3 .   ? -16.120 -1.691  -0.901  1.000 21.918  0  631 HOH A O     1 ? 
HETATM 2806 O O     . HOH D 3 .   ? 10.801  -10.486 -9.358  1.000 27.071  0  632 HOH A O     1 ? 
HETATM 2807 O O     . HOH D 3 .   ? 7.214   -19.938 14.654  1.000 31.647  0  633 HOH A O     1 ? 
HETATM 2808 O O     . HOH D 3 .   ? 1.624   -12.306 -15.136 1.000 33.653  0  634 HOH A O     1 ? 
HETATM 2809 O O     . HOH D 3 .   ? -10.882 -4.339  -21.712 1.000 25.925  0  635 HOH A O     1 ? 
HETATM 2810 O O     . HOH D 3 .   ? 16.221  -6.045  6.750   1.000 31.084  0  636 HOH A O     1 ? 
HETATM 2811 O O     . HOH D 3 .   ? 3.898   15.177  -16.834 1.000 13.363  0  637 HOH A O     1 ? 
HETATM 2812 O O     . HOH D 3 .   ? 13.168  -3.953  -8.716  1.000 22.037  0  638 HOH A O     1 ? 
HETATM 2813 O O     . HOH D 3 .   ? -16.811 -3.470  -20.493 1.000 39.301  0  639 HOH A O     1 ? 
HETATM 2814 O O     . HOH D 3 .   ? -13.927 21.252  -22.558 1.000 26.181  0  640 HOH A O     1 ? 
HETATM 2815 O O     . HOH D 3 .   ? 13.825  -6.693  5.378   1.000 18.047  0  641 HOH A O     1 ? 
HETATM 2816 O O     . HOH D 3 .   ? -15.238 -17.007 -1.954  1.000 26.466  0  642 HOH A O     1 ? 
HETATM 2817 O O     . HOH D 3 .   ? -4.006  7.396   3.603   1.000 27.241  0  643 HOH A O     1 ? 
HETATM 2818 O O     . HOH D 3 .   ? 0.480   -10.370 -17.948 1.000 25.044  0  644 HOH A O     1 ? 
HETATM 2819 O O     . HOH D 3 .   ? -0.794  22.487  -13.723 1.000 30.158  0  645 HOH A O     1 ? 
HETATM 2820 O O     . HOH D 3 .   ? 3.859   18.582  -9.750  1.000 43.046  0  646 HOH A O     1 ? 
HETATM 2821 O O     . HOH D 3 .   ? -19.273 -20.170 -12.973 1.000 30.564  0  647 HOH A O     1 ? 
HETATM 2822 O O     . HOH D 3 .   ? -12.612 12.513  -3.214  1.000 28.919  0  648 HOH A O     1 ? 
HETATM 2823 O O     . HOH D 3 .   ? -14.443 2.822   -23.370 1.000 33.638  0  649 HOH A O     1 ? 
HETATM 2824 O O     . HOH D 3 .   ? 15.558  -0.070  -14.074 1.000 28.647  0  650 HOH A O     1 ? 
HETATM 2825 O O     . HOH D 3 .   ? 4.294   -8.133  13.992  1.000 24.248  0  651 HOH A O     1 ? 
HETATM 2826 O O     . HOH D 3 .   ? -13.145 -19.146 -6.230  1.000 23.669  0  652 HOH A O     1 ? 
HETATM 2827 O O     . HOH D 3 .   ? 13.473  0.859   5.942   1.000 28.537  0  653 HOH A O     1 ? 
HETATM 2828 O O     . HOH D 3 .   ? -3.062  -2.997  10.585  1.000 46.982  0  654 HOH A O     1 ? 
HETATM 2829 O O     . HOH D 3 .   ? -12.062 -2.471  -23.785 1.000 42.074  0  655 HOH A O     1 ? 
HETATM 2830 O O     . HOH D 3 .   ? 15.400  -8.601  -3.421  1.000 34.326  0  656 HOH A O     1 ? 
HETATM 2831 O O     . HOH D 3 .   ? 5.745   10.613  -8.381  1.000 23.195  0  657 HOH A O     1 ? 
HETATM 2832 O O     . HOH D 3 .   ? -6.981  3.252   -25.999 1.000 37.997  0  658 HOH A O     1 ? 
HETATM 2833 O O     . HOH D 3 .   ? -17.340 -15.242 -2.264  1.000 19.349  0  659 HOH A O     1 ? 
HETATM 2834 O O     . HOH D 3 .   ? -2.505  -9.963  2.626   1.000 35.460  0  660 HOH A O     1 ? 
HETATM 2835 O O     . HOH D 3 .   ? 4.436   2.463   -23.321 1.000 35.537  0  661 HOH A O     1 ? 
HETATM 2836 O O     . HOH D 3 .   ? -24.258 -24.485 -3.860  1.000 39.955  0  662 HOH A O     1 ? 
HETATM 2837 O O     . HOH D 3 .   ? -1.713  21.386  -8.812  1.000 23.080  0  663 HOH A O     1 ? 
HETATM 2838 O O     . HOH D 3 .   ? 9.936   4.368   -6.984  1.000 20.542  0  664 HOH A O     1 ? 
HETATM 2839 O O     . HOH D 3 .   ? -0.132  19.811  -13.990 1.000 33.965  0  665 HOH A O     1 ? 
HETATM 2840 O O     . HOH D 3 .   ? 13.584  8.220   -16.096 1.000 25.596  0  666 HOH A O     1 ? 
HETATM 2841 O O     . HOH D 3 .   ? 6.901   -14.082 -6.125  1.000 25.508  0  667 HOH A O     1 ? 
HETATM 2842 O O     . HOH D 3 .   ? -1.975  -3.595  -21.587 1.000 31.559  0  668 HOH A O     1 ? 
HETATM 2843 O O     . HOH D 3 .   ? 14.381  3.136   7.879   1.000 32.887  0  669 HOH A O     1 ? 
HETATM 2844 O O     . HOH D 3 .   ? -3.629  23.106  -9.732  1.000 19.437  0  670 HOH A O     1 ? 
HETATM 2845 O O     . HOH D 3 .   ? 6.462   4.545   -23.571 1.000 27.243  0  671 HOH A O     1 ? 
HETATM 2846 O O     . HOH D 3 .   ? -2.399  17.802  -20.776 1.000 18.496  0  672 HOH A O     1 ? 
HETATM 2847 O O     . HOH D 3 .   ? -1.675  -22.135 16.955  1.000 54.528  0  673 HOH A O     1 ? 
HETATM 2848 O O     . HOH D 3 .   ? 12.775  8.985   8.192   1.000 29.648  0  674 HOH A O     1 ? 
HETATM 2849 O O     . HOH D 3 .   ? 14.018  3.668   -15.525 1.000 15.840  0  675 HOH A O     1 ? 
HETATM 2850 O O     . HOH D 3 .   ? -17.125 11.855  -8.875  1.000 31.928  0  676 HOH A O     1 ? 
HETATM 2851 O O     . HOH D 3 .   ? 11.235  8.289   -4.275  1.000 18.194  0  677 HOH A O     1 ? 
HETATM 2852 O O     . HOH D 3 .   ? -11.623 20.676  -25.259 1.000 30.573  0  678 HOH A O     1 ? 
HETATM 2853 O O     . HOH D 3 .   ? 16.102  -18.128 17.828  1.000 29.878  0  679 HOH A O     1 ? 
HETATM 2854 O O     . HOH D 3 .   ? 11.137  17.128  6.034   1.000 37.857  0  680 HOH A O     1 ? 
HETATM 2855 O O     . HOH D 3 .   ? 3.430   7.961   -24.611 1.000 29.263  0  681 HOH A O     1 ? 
HETATM 2856 O O     . HOH D 3 .   ? -22.799 3.294   -0.360  1.000 36.254  0  682 HOH A O     1 ? 
HETATM 2857 O O     . HOH D 3 .   ? -1.586  -2.532  2.462   1.000 18.930  0  683 HOH A O     1 ? 
HETATM 2858 O O     . HOH D 3 .   ? -15.194 -14.470 -16.520 1.000 43.586  0  684 HOH A O     1 ? 
HETATM 2859 O O     . HOH D 3 .   ? 12.314  5.834   4.413   1.000 42.670  0  685 HOH A O     1 ? 
HETATM 2860 O O     . HOH D 3 .   ? 13.893  -7.761  -10.932 1.000 41.178  0  686 HOH A O     1 ? 
HETATM 2861 O O     . HOH D 3 .   ? 9.790   -5.902  -11.996 1.000 25.440  0  687 HOH A O     1 ? 
HETATM 2862 O O     . HOH D 3 .   ? -18.103 0.898   -17.940 1.000 24.175  0  688 HOH A O     1 ? 
HETATM 2863 O O     . HOH D 3 .   ? 5.773   12.785  -9.744  1.000 13.443  0  689 HOH A O     1 ? 
HETATM 2864 O O     . HOH D 3 .   ? -17.666 -15.197 -12.480 1.000 41.648  0  690 HOH A O     1 ? 
HETATM 2865 O O     . HOH D 3 .   ? 15.883  -7.234  -9.734  1.000 30.964  0  691 HOH A O     1 ? 
HETATM 2866 O O     . HOH D 3 .   ? 6.650   10.752  -5.950  1.000 13.611  0  692 HOH A O     1 ? 
HETATM 2867 O O     . HOH D 3 .   ? 3.215   16.773  -5.558  1.000 40.659  0  693 HOH A O     1 ? 
HETATM 2868 O O     . HOH D 3 .   ? 5.850   15.112  -18.675 1.000 22.656  0  694 HOH A O     1 ? 
HETATM 2869 O O     . HOH D 3 .   ? -21.630 -22.704 -12.374 1.000 32.578  0  695 HOH A O     1 ? 
HETATM 2870 O O     . HOH D 3 .   ? 5.659   15.729  -6.153  1.000 42.965  0  696 HOH A O     1 ? 
HETATM 2871 O O     . HOH D 3 .   ? -12.893 -17.395 -4.445  1.000 23.044  0  697 HOH A O     1 ? 
HETATM 2872 O O     . HOH D 3 .   ? -21.845 -30.329 -6.008  1.000 42.347  0  698 HOH A O     1 ? 
HETATM 2873 O O     . HOH D 3 .   ? 1.752   -2.997  -20.596 1.000 29.461  0  699 HOH A O     1 ? 
HETATM 2874 O O     . HOH D 3 .   ? -19.746 -4.804  -8.433  1.000 30.842  0  700 HOH A O     1 ? 
HETATM 2875 O O     . HOH D 3 .   ? -1.196  -9.151  -20.544 1.000 41.662  0  701 HOH A O     1 ? 
HETATM 2876 O O     . HOH D 3 .   ? 2.608   12.814  -25.735 1.000 39.701  0  702 HOH A O     1 ? 
HETATM 2877 O O     . HOH D 3 .   ? 12.424  4.655   11.873  1.000 41.412  0  703 HOH A O     1 ? 
HETATM 2878 O O     . HOH D 3 .   ? -23.954 -16.399 -6.918  1.000 32.283  0  704 HOH A O     1 ? 
HETATM 2879 O O     . HOH D 3 .   ? 4.759   15.142  -8.725  1.000 20.396  0  705 HOH A O     1 ? 
HETATM 2880 O O     . HOH D 3 .   ? -19.477 14.069  -20.157 1.000 37.503  0  706 HOH A O     1 ? 
HETATM 2881 O O     . HOH D 3 .   ? 4.237   17.566  -27.909 1.000 40.993  0  707 HOH A O     1 ? 
HETATM 2882 O O     . HOH D 3 .   ? -17.621 18.638  -12.341 1.000 36.557  0  708 HOH A O     1 ? 
HETATM 2883 O O     . HOH D 3 .   ? 7.908   14.198  -15.561 1.000 28.060  0  709 HOH A O     1 ? 
HETATM 2884 O O     . HOH D 3 .   ? -10.803 -16.215 0.952   1.000 45.019  0  710 HOH A O     1 ? 
HETATM 2885 O O     . HOH D 3 .   ? -1.558  6.428   -26.502 1.000 38.132  0  711 HOH A O     1 ? 
HETATM 2886 O O     . HOH D 3 .   ? -17.505 -11.389 2.790   1.000 42.273  0  712 HOH A O     1 ? 
HETATM 2887 O O     . HOH D 3 .   ? 8.346   14.097  -10.589 1.000 40.496  0  713 HOH A O     1 ? 
HETATM 2888 O O     . HOH D 3 .   ? 12.619  -5.088  -11.010 1.000 26.473  0  714 HOH A O     1 ? 
HETATM 2889 O O     . HOH D 3 .   ? -16.553 6.774   -19.030 1.000 30.907  0  715 HOH A O     1 ? 
HETATM 2890 O O     . HOH D 3 .   ? 1.382   3.973   28.580  1.000 45.931  0  716 HOH A O     1 ? 
HETATM 2891 O O     . HOH D 3 .   ? 11.826  5.760   -4.438  1.000 30.765  0  717 HOH A O     1 ? 
HETATM 2892 O O     . HOH D 3 .   ? -15.541 -7.535  -15.548 1.000 36.904  0  718 HOH A O     1 ? 
HETATM 2893 O O     . HOH D 3 .   ? 11.057  1.510   -18.927 1.000 33.308  0  719 HOH A O     1 ? 
HETATM 2894 O O     . HOH D 3 .   ? 8.024   15.258  -17.509 1.000 38.602  0  720 HOH A O     1 ? 
HETATM 2895 O O     . HOH D 3 .   ? -19.198 -13.999 -0.170  1.000 35.948  0  721 HOH A O     1 ? 
HETATM 2896 O O     . HOH D 3 .   ? 13.858  -10.615 26.885  1.000 41.203  0  722 HOH A O     1 ? 
HETATM 2897 O O     . HOH D 3 .   ? 2.721   -12.616 -10.824 1.000 38.645  0  723 HOH A O     1 ? 
HETATM 2898 O O     . HOH D 3 .   ? -6.324  -19.374 -7.044  1.000 35.907  0  724 HOH A O     1 ? 
HETATM 2899 O O     . HOH D 3 .   ? 16.050  10.285  -8.495  1.000 31.621  0  725 HOH A O     1 ? 
HETATM 2900 O O     . HOH D 3 .   ? 1.431   19.442  -16.115 1.000 27.614  0  726 HOH A O     1 ? 
HETATM 2901 O O     . HOH D 3 .   ? 14.995  1.258   -16.189 1.000 38.407  0  727 HOH A O     1 ? 
HETATM 2902 O O     . HOH D 3 .   ? -14.581 11.598  -1.691  1.000 35.034  0  728 HOH A O     1 ? 
HETATM 2903 O O     . HOH D 3 .   ? 9.495   -14.384 -7.333  1.000 31.377  0  729 HOH A O     1 ? 
HETATM 2904 O O     . HOH D 3 .   ? -16.564 -11.351 -13.827 1.000 25.252  0  730 HOH A O     1 ? 
HETATM 2905 O O     . HOH D 3 .   ? -3.847  -2.475  -23.732 1.000 36.049  0  731 HOH A O     1 ? 
HETATM 2906 O O     . HOH D 3 .   ? -21.703 5.453   -2.411  1.000 31.331  0  732 HOH A O     1 ? 
HETATM 2907 O O     . HOH D 3 .   ? 11.819  15.930  -5.896  1.000 46.265  0  733 HOH A O     1 ? 
HETATM 2908 O O     . HOH D 3 .   ? -18.443 11.837  -4.725  1.000 41.316  0  734 HOH A O     1 ? 
# 
