data_8YSI
# 
_entry.id   8YSI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YSI         pdb_00008ysi 10.2210/pdb8ysi/pdb 
WWPDB D_1300046300 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YSI 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chyeah6599@nchu.edu.tw 
_pdbx_contact_author.name_first         Yeh 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7740-0446 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, Y.-C.' 1 ? 
'Yang, C.-S.' 2 ? 
'Hou, M.-H.'  3 ? 
'Chen, Y.'    4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            295 
_citation.language                  ? 
_citation.page_first                139534 
_citation.page_last                 139534 
_citation.title                     
'Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.139534 
_citation.pdbx_database_id_PubMed   39761885 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, C.S.'  1 ? 
primary 'Shie, M.Y.'  2 ? 
primary 'Huang, S.W.' 3 ? 
primary 'Wang, Y.C.'  4 ? 
primary 'Hou, M.H.'   5 ? 
primary 'Chen, C.J.'  6 ? 
primary 'Chen, Y.'    7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleotidyltransferase    39217.918 1   ? ? ? ? 
2 non-polymer syn 
;URIDINE 5'-TRIPHOSPHATE
;
484.141   2   ? ? ? ? 
3 water       nat water                     18.015    254 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;URIDINE 5'-TRIPHOSPHATE
;
UTP 
3 water                     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PRO n 
1 4   VAL n 
1 5   GLN n 
1 6   LYS n 
1 7   GLN n 
1 8   PHE n 
1 9   ARG n 
1 10  GLU n 
1 11  PHE n 
1 12  HIS n 
1 13  ASP n 
1 14  ARG n 
1 15  ILE n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLN n 
1 20  TYR n 
1 21  ASP n 
1 22  GLU n 
1 23  ASN n 
1 24  GLN n 
1 25  THR n 
1 26  LEU n 
1 27  ARG n 
1 28  ASP n 
1 29  GLU n 
1 30  ARG n 
1 31  ASP n 
1 32  ALA n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  ALA n 
1 37  VAL n 
1 38  ARG n 
1 39  GLU n 
1 40  GLY n 
1 41  LEU n 
1 42  LYS n 
1 43  LYS n 
1 44  VAL n 
1 45  PHE n 
1 46  ALA n 
1 47  ASP n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  ALA n 
1 52  ALA n 
1 53  PRO n 
1 54  THR n 
1 55  PHE n 
1 56  THR n 
1 57  PRO n 
1 58  PHE n 
1 59  ASN n 
1 60  GLN n 
1 61  GLY n 
1 62  SER n 
1 63  TYR n 
1 64  ALA n 
1 65  MET n 
1 66  ASN n 
1 67  THR n 
1 68  GLY n 
1 69  VAL n 
1 70  LYS n 
1 71  PRO n 
1 72  LEU n 
1 73  GLU n 
1 74  GLY n 
1 75  GLY n 
1 76  GLU n 
1 77  TYR n 
1 78  ASP n 
1 79  ILE n 
1 80  ASP n 
1 81  VAL n 
1 82  GLY n 
1 83  ILE n 
1 84  ILE n 
1 85  LEU n 
1 86  ASN n 
1 87  ILE n 
1 88  ALA n 
1 89  LYS n 
1 90  ASP n 
1 91  ASP n 
1 92  HIS n 
1 93  ASP n 
1 94  PRO n 
1 95  VAL n 
1 96  GLU n 
1 97  VAL n 
1 98  LYS n 
1 99  LYS n 
1 100 TRP n 
1 101 ILE n 
1 102 ARG n 
1 103 ASP n 
1 104 ALA n 
1 105 LEU n 
1 106 LYS n 
1 107 ASP n 
1 108 TYR n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 ALA n 
1 113 GLU n 
1 114 ILE n 
1 115 ARG n 
1 116 ARG n 
1 117 SER n 
1 118 CYS n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 PHE n 
1 123 LYS n 
1 124 PRO n 
1 125 GLY n 
1 126 TYR n 
1 127 HIS n 
1 128 VAL n 
1 129 ASP n 
1 130 LEU n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 ALA n 
1 135 ASP n 
1 136 PRO n 
1 137 GLU n 
1 138 LEU n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 LEU n 
1 144 CYS n 
1 145 ILE n 
1 146 ALA n 
1 147 LYS n 
1 148 GLY n 
1 149 LYS n 
1 150 GLU n 
1 151 ASN n 
1 152 SER n 
1 153 GLY n 
1 154 ASP n 
1 155 GLU n 
1 156 HIS n 
1 157 ARG n 
1 158 LEU n 
1 159 TRP n 
1 160 GLN n 
1 161 ILE n 
1 162 SER n 
1 163 ASP n 
1 164 PRO n 
1 165 GLN n 
1 166 GLY n 
1 167 PHE n 
1 168 GLN n 
1 169 ASP n 
1 170 ARG n 
1 171 ILE n 
1 172 ALA n 
1 173 SER n 
1 174 LYS n 
1 175 LEU n 
1 176 SER n 
1 177 GLY n 
1 178 ASP n 
1 179 ASP n 
1 180 ALA n 
1 181 ALA n 
1 182 GLN n 
1 183 PHE n 
1 184 ARG n 
1 185 ARG n 
1 186 CYS n 
1 187 ILE n 
1 188 ARG n 
1 189 TYR n 
1 190 LEU n 
1 191 LYS n 
1 192 ARG n 
1 193 TRP n 
1 194 ARG n 
1 195 ASP n 
1 196 PHE n 
1 197 ARG n 
1 198 PHE n 
1 199 SER n 
1 200 SER n 
1 201 ASP n 
1 202 GLY n 
1 203 ASN n 
1 204 ALA n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 LEU n 
1 212 THR n 
1 213 ALA n 
1 214 ALA n 
1 215 ALA n 
1 216 TYR n 
1 217 TRP n 
1 218 TRP n 
1 219 PHE n 
1 220 GLN n 
1 221 VAL n 
1 222 SER n 
1 223 LYS n 
1 224 ARG n 
1 225 THR n 
1 226 ASP n 
1 227 PRO n 
1 228 VAL n 
1 229 SER n 
1 230 GLN n 
1 231 ASN n 
1 232 VAL n 
1 233 THR n 
1 234 TYR n 
1 235 ASP n 
1 236 ASP n 
1 237 ARG n 
1 238 ASP n 
1 239 ALA n 
1 240 LEU n 
1 241 GLU n 
1 242 GLN n 
1 243 PHE n 
1 244 VAL n 
1 245 GLN n 
1 246 THR n 
1 247 MET n 
1 248 LEU n 
1 249 ASP n 
1 250 ASN n 
1 251 PHE n 
1 252 HIS n 
1 253 ASP n 
1 254 THR n 
1 255 TRP n 
1 256 ASP n 
1 257 SER n 
1 258 LYS n 
1 259 ASP n 
1 260 GLN n 
1 261 ARG n 
1 262 SER n 
1 263 TYR n 
1 264 PRO n 
1 265 ARG n 
1 266 LEU n 
1 267 THR n 
1 268 VAL n 
1 269 GLU n 
1 270 LEU n 
1 271 PRO n 
1 272 VAL n 
1 273 GLN n 
1 274 PRO n 
1 275 TYR n 
1 276 ASN n 
1 277 ASP n 
1 278 VAL n 
1 279 PHE n 
1 280 GLU n 
1 281 LYS n 
1 282 MET n 
1 283 THR n 
1 284 GLY n 
1 285 MET n 
1 286 GLN n 
1 287 MET n 
1 288 GLU n 
1 289 SER n 
1 290 PHE n 
1 291 LYS n 
1 292 SER n 
1 293 LYS n 
1 294 LEU n 
1 295 GLN n 
1 296 ALA n 
1 297 LEU n 
1 298 LEU n 
1 299 ASN n 
1 300 ALA n 
1 301 LEU n 
1 302 LYS n 
1 303 THR n 
1 304 ALA n 
1 305 LYS n 
1 306 SER n 
1 307 ARG n 
1 308 LEU n 
1 309 GLU n 
1 310 LEU n 
1 311 HIS n 
1 312 ASP n 
1 313 ALA n 
1 314 CYS n 
1 315 LYS n 
1 316 ALA n 
1 317 LEU n 
1 318 ALA n 
1 319 ASP n 
1 320 HIS n 
1 321 PHE n 
1 322 GLY n 
1 323 SER n 
1 324 GLU n 
1 325 PHE n 
1 326 PRO n 
1 327 VAL n 
1 328 PRO n 
1 329 GLU n 
1 330 LYS n 
1 331 ASP n 
1 332 LYS n 
1 333 SER n 
1 334 ALA n 
1 335 VAL n 
1 336 HIS n 
1 337 THR n 
1 338 ALA n 
1 339 PRO n 
1 340 ALA n 
1 341 ILE n 
1 342 VAL n 
1 343 GLY n 
1 344 SER n 
1 345 GLY n 
1 346 SER n 
1 347 SER n 
1 348 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   348 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 DVJ83_15700 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Deinococcus wulumuqiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     980427 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                   ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                  ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'           ? 'C4 H7 N O4'       133.103 
CYS 'L-peptide linking' y CYSTEINE                  ? 'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking' y GLUTAMINE                 ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'           ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                   ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking' y HISTIDINE                 ? 'C6 H10 N3 O2 1'   156.162 
HOH non-polymer         . WATER                     ? 'H2 O'             18.015  
ILE 'L-peptide linking' y ISOLEUCINE                ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                   ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                    ? 'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE                ? 'C5 H11 N O2 S'    149.211 
PHE 'L-peptide linking' y PHENYLALANINE             ? 'C9 H11 N O2'      165.189 
PRO 'L-peptide linking' y PROLINE                   ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                    ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                 ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                  ? 'C9 H11 N O3'      181.189 
UTP non-polymer         . 
;URIDINE 5'-TRIPHOSPHATE
;
? 'C9 H15 N2 O15 P3' 484.141 
VAL 'L-peptide linking' y VALINE                    ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PRO 3   3   3   PRO PRO A . n 
A 1 4   VAL 4   4   4   VAL VAL A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ALA 18  18  18  ALA ALA A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ASP 28  28  28  ASP ASP A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  ARG 30  30  30  ARG ARG A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  THR 35  35  35  THR THR A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  PRO 53  53  53  PRO PRO A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  TYR 63  63  63  TYR TYR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  MET 65  65  65  MET MET A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 CYS 118 118 118 CYS CYS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 HIS 127 127 127 HIS HIS A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 GLY 141 141 141 GLY GLY A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 GLY 153 153 ?   ?   ?   A . n 
A 1 154 ASP 154 154 ?   ?   ?   A . n 
A 1 155 GLU 155 155 ?   ?   ?   A . n 
A 1 156 HIS 156 156 ?   ?   ?   A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 PRO 164 164 164 PRO PRO A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLN 168 168 168 GLN GLN A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 CYS 186 186 186 CYS CYS A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 VAL 221 221 221 VAL VAL A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLN 230 230 230 GLN GLN A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 TYR 234 234 234 TYR TYR A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 ARG 237 237 237 ARG ARG A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 PHE 243 243 243 PHE PHE A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 MET 247 247 247 MET MET A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 ASP 249 249 249 ASP ASP A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 HIS 252 252 252 HIS HIS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 TRP 255 255 255 TRP TRP A . n 
A 1 256 ASP 256 256 256 ASP ASP A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 PRO 264 264 264 PRO PRO A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 GLU 269 269 269 GLU GLU A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 ASP 277 277 277 ASP ASP A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 LYS 281 281 281 LYS LYS A . n 
A 1 282 MET 282 282 282 MET MET A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 SER 289 289 289 SER SER A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 GLN 295 295 295 GLN GLN A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 LEU 297 297 297 LEU LEU A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 SER 306 306 306 SER SER A . n 
A 1 307 ARG 307 307 307 ARG ARG A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 GLU 309 309 309 GLU GLU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 HIS 311 311 311 HIS HIS A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 ALA 318 318 318 ALA ALA A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 320 HIS HIS A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 GLU 324 324 324 GLU GLU A . n 
A 1 325 PHE 325 325 325 PHE PHE A . n 
A 1 326 PRO 326 326 326 PRO PRO A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 PRO 328 328 328 PRO PRO A . n 
A 1 329 GLU 329 329 329 GLU GLU A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 ASP 331 331 ?   ?   ?   A . n 
A 1 332 LYS 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 ALA 334 334 ?   ?   ?   A . n 
A 1 335 VAL 335 335 ?   ?   ?   A . n 
A 1 336 HIS 336 336 ?   ?   ?   A . n 
A 1 337 THR 337 337 ?   ?   ?   A . n 
A 1 338 ALA 338 338 ?   ?   ?   A . n 
A 1 339 PRO 339 339 ?   ?   ?   A . n 
A 1 340 ALA 340 340 ?   ?   ?   A . n 
A 1 341 ILE 341 341 ?   ?   ?   A . n 
A 1 342 VAL 342 342 ?   ?   ?   A . n 
A 1 343 GLY 343 343 ?   ?   ?   A . n 
A 1 344 SER 344 344 ?   ?   ?   A . n 
A 1 345 GLY 345 345 ?   ?   ?   A . n 
A 1 346 SER 346 346 ?   ?   ?   A . n 
A 1 347 SER 347 347 ?   ?   ?   A . n 
A 1 348 GLY 348 348 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UTP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UTP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UTP 1   401 401 UTP UTP A . 
C 2 UTP 1   402 402 UTP UTP A . 
D 3 HOH 1   501 520 HOH HOH A . 
D 3 HOH 2   502 648 HOH HOH A . 
D 3 HOH 3   503 688 HOH HOH A . 
D 3 HOH 4   504 726 HOH HOH A . 
D 3 HOH 5   505 685 HOH HOH A . 
D 3 HOH 6   506 545 HOH HOH A . 
D 3 HOH 7   507 708 HOH HOH A . 
D 3 HOH 8   508 676 HOH HOH A . 
D 3 HOH 9   509 738 HOH HOH A . 
D 3 HOH 10  510 631 HOH HOH A . 
D 3 HOH 11  511 697 HOH HOH A . 
D 3 HOH 12  512 658 HOH HOH A . 
D 3 HOH 13  513 647 HOH HOH A . 
D 3 HOH 14  514 515 HOH HOH A . 
D 3 HOH 15  515 710 HOH HOH A . 
D 3 HOH 16  516 512 HOH HOH A . 
D 3 HOH 17  517 721 HOH HOH A . 
D 3 HOH 18  518 665 HOH HOH A . 
D 3 HOH 19  519 604 HOH HOH A . 
D 3 HOH 20  520 547 HOH HOH A . 
D 3 HOH 21  521 523 HOH HOH A . 
D 3 HOH 22  522 702 HOH HOH A . 
D 3 HOH 23  523 554 HOH HOH A . 
D 3 HOH 24  524 683 HOH HOH A . 
D 3 HOH 25  525 675 HOH HOH A . 
D 3 HOH 26  526 610 HOH HOH A . 
D 3 HOH 27  527 566 HOH HOH A . 
D 3 HOH 28  528 626 HOH HOH A . 
D 3 HOH 29  529 535 HOH HOH A . 
D 3 HOH 30  530 506 HOH HOH A . 
D 3 HOH 31  531 735 HOH HOH A . 
D 3 HOH 32  532 627 HOH HOH A . 
D 3 HOH 33  533 686 HOH HOH A . 
D 3 HOH 34  534 553 HOH HOH A . 
D 3 HOH 35  535 599 HOH HOH A . 
D 3 HOH 36  536 628 HOH HOH A . 
D 3 HOH 37  537 556 HOH HOH A . 
D 3 HOH 38  538 522 HOH HOH A . 
D 3 HOH 39  539 695 HOH HOH A . 
D 3 HOH 40  540 612 HOH HOH A . 
D 3 HOH 41  541 722 HOH HOH A . 
D 3 HOH 42  542 664 HOH HOH A . 
D 3 HOH 43  543 519 HOH HOH A . 
D 3 HOH 44  544 652 HOH HOH A . 
D 3 HOH 45  545 543 HOH HOH A . 
D 3 HOH 46  546 541 HOH HOH A . 
D 3 HOH 47  547 713 HOH HOH A . 
D 3 HOH 48  548 517 HOH HOH A . 
D 3 HOH 49  549 663 HOH HOH A . 
D 3 HOH 50  550 503 HOH HOH A . 
D 3 HOH 51  551 742 HOH HOH A . 
D 3 HOH 52  552 642 HOH HOH A . 
D 3 HOH 53  553 567 HOH HOH A . 
D 3 HOH 54  554 591 HOH HOH A . 
D 3 HOH 55  555 581 HOH HOH A . 
D 3 HOH 56  556 611 HOH HOH A . 
D 3 HOH 57  557 619 HOH HOH A . 
D 3 HOH 58  558 571 HOH HOH A . 
D 3 HOH 59  559 653 HOH HOH A . 
D 3 HOH 60  560 602 HOH HOH A . 
D 3 HOH 61  561 550 HOH HOH A . 
D 3 HOH 62  562 719 HOH HOH A . 
D 3 HOH 63  563 575 HOH HOH A . 
D 3 HOH 64  564 659 HOH HOH A . 
D 3 HOH 65  565 681 HOH HOH A . 
D 3 HOH 66  566 533 HOH HOH A . 
D 3 HOH 67  567 601 HOH HOH A . 
D 3 HOH 68  568 521 HOH HOH A . 
D 3 HOH 69  569 645 HOH HOH A . 
D 3 HOH 70  570 700 HOH HOH A . 
D 3 HOH 71  571 644 HOH HOH A . 
D 3 HOH 72  572 539 HOH HOH A . 
D 3 HOH 73  573 607 HOH HOH A . 
D 3 HOH 74  574 514 HOH HOH A . 
D 3 HOH 75  575 694 HOH HOH A . 
D 3 HOH 76  576 629 HOH HOH A . 
D 3 HOH 77  577 684 HOH HOH A . 
D 3 HOH 78  578 638 HOH HOH A . 
D 3 HOH 79  579 546 HOH HOH A . 
D 3 HOH 80  580 584 HOH HOH A . 
D 3 HOH 81  581 536 HOH HOH A . 
D 3 HOH 82  582 690 HOH HOH A . 
D 3 HOH 83  583 564 HOH HOH A . 
D 3 HOH 84  584 549 HOH HOH A . 
D 3 HOH 85  585 513 HOH HOH A . 
D 3 HOH 86  586 687 HOH HOH A . 
D 3 HOH 87  587 749 HOH HOH A . 
D 3 HOH 88  588 691 HOH HOH A . 
D 3 HOH 89  589 622 HOH HOH A . 
D 3 HOH 90  590 732 HOH HOH A . 
D 3 HOH 91  591 544 HOH HOH A . 
D 3 HOH 92  592 551 HOH HOH A . 
D 3 HOH 93  593 501 HOH HOH A . 
D 3 HOH 94  594 542 HOH HOH A . 
D 3 HOH 95  595 570 HOH HOH A . 
D 3 HOH 96  596 605 HOH HOH A . 
D 3 HOH 97  597 590 HOH HOH A . 
D 3 HOH 98  598 524 HOH HOH A . 
D 3 HOH 99  599 639 HOH HOH A . 
D 3 HOH 100 600 509 HOH HOH A . 
D 3 HOH 101 601 662 HOH HOH A . 
D 3 HOH 102 602 561 HOH HOH A . 
D 3 HOH 103 603 630 HOH HOH A . 
D 3 HOH 104 604 593 HOH HOH A . 
D 3 HOH 105 605 635 HOH HOH A . 
D 3 HOH 106 606 500 HOH HOH A . 
D 3 HOH 107 607 588 HOH HOH A . 
D 3 HOH 108 608 618 HOH HOH A . 
D 3 HOH 109 609 744 HOH HOH A . 
D 3 HOH 110 610 558 HOH HOH A . 
D 3 HOH 111 611 743 HOH HOH A . 
D 3 HOH 112 612 741 HOH HOH A . 
D 3 HOH 113 613 589 HOH HOH A . 
D 3 HOH 114 614 580 HOH HOH A . 
D 3 HOH 115 615 532 HOH HOH A . 
D 3 HOH 116 616 603 HOH HOH A . 
D 3 HOH 117 617 504 HOH HOH A . 
D 3 HOH 118 618 574 HOH HOH A . 
D 3 HOH 119 619 617 HOH HOH A . 
D 3 HOH 120 620 748 HOH HOH A . 
D 3 HOH 121 621 615 HOH HOH A . 
D 3 HOH 122 622 649 HOH HOH A . 
D 3 HOH 123 623 559 HOH HOH A . 
D 3 HOH 124 624 696 HOH HOH A . 
D 3 HOH 125 625 577 HOH HOH A . 
D 3 HOH 126 626 578 HOH HOH A . 
D 3 HOH 127 627 511 HOH HOH A . 
D 3 HOH 128 628 613 HOH HOH A . 
D 3 HOH 129 629 750 HOH HOH A . 
D 3 HOH 130 630 670 HOH HOH A . 
D 3 HOH 131 631 668 HOH HOH A . 
D 3 HOH 132 632 510 HOH HOH A . 
D 3 HOH 133 633 692 HOH HOH A . 
D 3 HOH 134 634 596 HOH HOH A . 
D 3 HOH 135 635 616 HOH HOH A . 
D 3 HOH 136 636 608 HOH HOH A . 
D 3 HOH 137 637 614 HOH HOH A . 
D 3 HOH 138 638 632 HOH HOH A . 
D 3 HOH 139 639 621 HOH HOH A . 
D 3 HOH 140 640 712 HOH HOH A . 
D 3 HOH 141 641 623 HOH HOH A . 
D 3 HOH 142 642 569 HOH HOH A . 
D 3 HOH 143 643 534 HOH HOH A . 
D 3 HOH 144 644 633 HOH HOH A . 
D 3 HOH 145 645 643 HOH HOH A . 
D 3 HOH 146 646 620 HOH HOH A . 
D 3 HOH 147 647 502 HOH HOH A . 
D 3 HOH 148 648 518 HOH HOH A . 
D 3 HOH 149 649 562 HOH HOH A . 
D 3 HOH 150 650 656 HOH HOH A . 
D 3 HOH 151 651 565 HOH HOH A . 
D 3 HOH 152 652 505 HOH HOH A . 
D 3 HOH 153 653 641 HOH HOH A . 
D 3 HOH 154 654 540 HOH HOH A . 
D 3 HOH 155 655 508 HOH HOH A . 
D 3 HOH 156 656 727 HOH HOH A . 
D 3 HOH 157 657 527 HOH HOH A . 
D 3 HOH 158 658 737 HOH HOH A . 
D 3 HOH 159 659 704 HOH HOH A . 
D 3 HOH 160 660 640 HOH HOH A . 
D 3 HOH 161 661 548 HOH HOH A . 
D 3 HOH 162 662 698 HOH HOH A . 
D 3 HOH 163 663 677 HOH HOH A . 
D 3 HOH 164 664 646 HOH HOH A . 
D 3 HOH 165 665 528 HOH HOH A . 
D 3 HOH 166 666 587 HOH HOH A . 
D 3 HOH 167 667 705 HOH HOH A . 
D 3 HOH 168 668 752 HOH HOH A . 
D 3 HOH 169 669 530 HOH HOH A . 
D 3 HOH 170 670 576 HOH HOH A . 
D 3 HOH 171 671 537 HOH HOH A . 
D 3 HOH 172 672 706 HOH HOH A . 
D 3 HOH 173 673 563 HOH HOH A . 
D 3 HOH 174 674 667 HOH HOH A . 
D 3 HOH 175 675 568 HOH HOH A . 
D 3 HOH 176 676 526 HOH HOH A . 
D 3 HOH 177 677 747 HOH HOH A . 
D 3 HOH 178 678 525 HOH HOH A . 
D 3 HOH 179 679 582 HOH HOH A . 
D 3 HOH 180 680 598 HOH HOH A . 
D 3 HOH 181 681 651 HOH HOH A . 
D 3 HOH 182 682 657 HOH HOH A . 
D 3 HOH 183 683 637 HOH HOH A . 
D 3 HOH 184 684 661 HOH HOH A . 
D 3 HOH 185 685 716 HOH HOH A . 
D 3 HOH 186 686 609 HOH HOH A . 
D 3 HOH 187 687 557 HOH HOH A . 
D 3 HOH 188 688 507 HOH HOH A . 
D 3 HOH 189 689 555 HOH HOH A . 
D 3 HOH 190 690 529 HOH HOH A . 
D 3 HOH 191 691 699 HOH HOH A . 
D 3 HOH 192 692 585 HOH HOH A . 
D 3 HOH 193 693 693 HOH HOH A . 
D 3 HOH 194 694 579 HOH HOH A . 
D 3 HOH 195 695 669 HOH HOH A . 
D 3 HOH 196 696 606 HOH HOH A . 
D 3 HOH 197 697 734 HOH HOH A . 
D 3 HOH 198 698 531 HOH HOH A . 
D 3 HOH 199 699 538 HOH HOH A . 
D 3 HOH 200 700 573 HOH HOH A . 
D 3 HOH 201 701 717 HOH HOH A . 
D 3 HOH 202 702 723 HOH HOH A . 
D 3 HOH 203 703 736 HOH HOH A . 
D 3 HOH 204 704 703 HOH HOH A . 
D 3 HOH 205 705 516 HOH HOH A . 
D 3 HOH 206 706 624 HOH HOH A . 
D 3 HOH 207 707 674 HOH HOH A . 
D 3 HOH 208 708 560 HOH HOH A . 
D 3 HOH 209 709 666 HOH HOH A . 
D 3 HOH 210 710 733 HOH HOH A . 
D 3 HOH 211 711 592 HOH HOH A . 
D 3 HOH 212 712 595 HOH HOH A . 
D 3 HOH 213 713 654 HOH HOH A . 
D 3 HOH 214 714 597 HOH HOH A . 
D 3 HOH 215 715 679 HOH HOH A . 
D 3 HOH 216 716 745 HOH HOH A . 
D 3 HOH 217 717 600 HOH HOH A . 
D 3 HOH 218 718 671 HOH HOH A . 
D 3 HOH 219 719 634 HOH HOH A . 
D 3 HOH 220 720 707 HOH HOH A . 
D 3 HOH 221 721 689 HOH HOH A . 
D 3 HOH 222 722 715 HOH HOH A . 
D 3 HOH 223 723 572 HOH HOH A . 
D 3 HOH 224 724 753 HOH HOH A . 
D 3 HOH 225 725 655 HOH HOH A . 
D 3 HOH 226 726 660 HOH HOH A . 
D 3 HOH 227 727 731 HOH HOH A . 
D 3 HOH 228 728 709 HOH HOH A . 
D 3 HOH 229 729 586 HOH HOH A . 
D 3 HOH 230 730 725 HOH HOH A . 
D 3 HOH 231 731 701 HOH HOH A . 
D 3 HOH 232 732 583 HOH HOH A . 
D 3 HOH 233 733 740 HOH HOH A . 
D 3 HOH 234 734 711 HOH HOH A . 
D 3 HOH 235 735 720 HOH HOH A . 
D 3 HOH 236 736 650 HOH HOH A . 
D 3 HOH 237 737 724 HOH HOH A . 
D 3 HOH 238 738 730 HOH HOH A . 
D 3 HOH 239 739 751 HOH HOH A . 
D 3 HOH 240 740 680 HOH HOH A . 
D 3 HOH 241 741 746 HOH HOH A . 
D 3 HOH 242 742 729 HOH HOH A . 
D 3 HOH 243 743 672 HOH HOH A . 
D 3 HOH 244 744 552 HOH HOH A . 
D 3 HOH 245 745 673 HOH HOH A . 
D 3 HOH 246 746 739 HOH HOH A . 
D 3 HOH 247 747 718 HOH HOH A . 
D 3 HOH 248 748 714 HOH HOH A . 
D 3 HOH 249 749 682 HOH HOH A . 
D 3 HOH 250 750 594 HOH HOH A . 
D 3 HOH 251 751 678 HOH HOH A . 
D 3 HOH 252 752 625 HOH HOH A . 
D 3 HOH 253 753 636 HOH HOH A . 
D 3 HOH 254 754 728 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0267 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? Blu-Ice  ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
# 
_cell.angle_alpha                  101.796 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   106.802 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  95.768 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YSI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.375 
_cell.length_a_esd                 ? 
_cell.length_b                     46.302 
_cell.length_b_esd                 ? 
_cell.length_c                     60.792 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        1 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YSI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YSI 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.2 M MOPS pH 6.5, 
20% w/v Polyethylene glycol 4,000.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-10-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.99984 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 05A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.99984 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 05A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YSI 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.897 
_reflns.d_resolution_low                               30 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26575 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           94.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          21.865 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.038 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.897 
_reflns_shell.d_res_low                                     1.97 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2733 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.983 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.095 
_refine.aniso_B[1][2]                            -0.015 
_refine.aniso_B[1][3]                            0.146 
_refine.aniso_B[2][2]                            -0.180 
_refine.aniso_B[2][3]                            -0.301 
_refine.aniso_B[3][3]                            0.125 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.106 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.948 
_refine.correlation_coeff_Fo_to_Fc_free          0.933 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YSI 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.897 
_refine.ls_d_res_low                             23.452 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26517 
_refine.ls_number_reflns_R_free                  1320 
_refine.ls_number_reflns_R_work                  25197 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    93.975 
_refine.ls_percent_reflns_R_free                 4.978 
_refine.ls_R_factor_all                          0.177 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2070 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1752 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.161 
_refine.pdbx_overall_ESU_R_Free                  0.139 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             2.890 
_refine.overall_SU_ML                            0.087 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2616 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             254 
_refine_hist.number_atoms_total               2928 
_refine_hist.d_res_high                       1.897 
_refine_hist.d_res_low                        23.452 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.013  2735 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2514 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.425  1.654  3708 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.308  1.593  5791 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.731  5.000  324  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 32.389 22.050 161  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.466 15.000 460  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 16.556 15.000 22   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.070  0.200  345  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  3078 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  658  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.206  0.200  567  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.188  0.200  2292 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.166  0.200  1342 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.078  0.200  1265 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.179  0.200  181  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.200  1    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.157  0.200  21   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.207  0.200  59   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.187  0.200  21   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.314  2.269  1302 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.314  2.267  1301 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 3.371  3.385  1624 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.371  3.387  1625 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.137  2.696  1433 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.136  2.697  1434 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.859  3.917  2084 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.858  3.918  2085 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 6.547  26.830 3158 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 6.466  26.646 3115 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.897 1.946  . . 89  1724 87.3735 . . . . 0.196 . . . . . . . . . . . 0.221 
'X-RAY DIFFRACTION' 1.946 1.999  . . 86  1860 95.8621 . . . . 0.181 . . . . . . . . . . . 0.228 
'X-RAY DIFFRACTION' 1.999 2.057  . . 82  1829 96.8576 . . . . 0.177 . . . . . . . . . . . 0.209 
'X-RAY DIFFRACTION' 2.057 2.120  . . 94  1775 96.8896 . . . . 0.173 . . . . . . . . . . . 0.234 
'X-RAY DIFFRACTION' 2.120 2.189  . . 105 1695 96.8784 . . . . 0.158 . . . . . . . . . . . 0.200 
'X-RAY DIFFRACTION' 2.189 2.265  . . 101 1618 96.5188 . . . . 0.174 . . . . . . . . . . . 0.215 
'X-RAY DIFFRACTION' 2.265 2.350  . . 86  1632 97.3371 . . . . 0.163 . . . . . . . . . . . 0.213 
'X-RAY DIFFRACTION' 2.350 2.446  . . 80  1515 96.3164 . . . . 0.154 . . . . . . . . . . . 0.196 
'X-RAY DIFFRACTION' 2.446 2.554  . . 69  1462 96.4106 . . . . 0.161 . . . . . . . . . . . 0.206 
'X-RAY DIFFRACTION' 2.554 2.677  . . 82  1365 95.3856 . . . . 0.167 . . . . . . . . . . . 0.214 
'X-RAY DIFFRACTION' 2.677 2.821  . . 68  1285 94.4832 . . . . 0.174 . . . . . . . . . . . 0.198 
'X-RAY DIFFRACTION' 2.821 2.991  . . 66  1261 94.3141 . . . . 0.176 . . . . . . . . . . . 0.195 
'X-RAY DIFFRACTION' 2.991 3.195  . . 68  1134 91.8960 . . . . 0.167 . . . . . . . . . . . 0.235 
'X-RAY DIFFRACTION' 3.195 3.447  . . 40  1041 90.3091 . . . . 0.181 . . . . . . . . . . . 0.158 
'X-RAY DIFFRACTION' 3.447 3.771  . . 45  953  90.3167 . . . . 0.179 . . . . . . . . . . . 0.194 
'X-RAY DIFFRACTION' 3.771 4.208  . . 44  854  89.1758 . . . . 0.177 . . . . . . . . . . . 0.190 
'X-RAY DIFFRACTION' 4.208 4.844  . . 40  744  88.4876 . . . . 0.169 . . . . . . . . . . . 0.208 
'X-RAY DIFFRACTION' 4.844 5.894  . . 23  675  90.4145 . . . . 0.208 . . . . . . . . . . . 0.250 
'X-RAY DIFFRACTION' 5.894 8.179  . . 35  492  92.2942 . . . . 0.201 . . . . . . . . . . . 0.227 
'X-RAY DIFFRACTION' 8.179 23.452 . . 17  283  84.9858 . . . . 0.197 . . . . . . . . . . . 0.184 
# 
_struct.entry_id                     8YSI 
_struct.title                        'Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with UTP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YSI 
_struct_keywords.text            'CD-NTase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A345ILN6_9DEIO 
_struct_ref.pdbx_db_accession          A0A345ILN6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YSI 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 348 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A345ILN6 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  348 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       348 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 4   ? LYS A 16  ? VAL A 4   LYS A 16  1 ? 13 
HELX_P HELX_P2  AA2 GLN A 19  ? GLU A 22  ? GLN A 19  GLU A 22  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 23  ? ALA A 46  ? ASN A 23  ALA A 46  1 ? 24 
HELX_P HELX_P4  AA4 GLY A 61  ? ASN A 66  ? GLY A 61  ASN A 66  1 ? 6  
HELX_P HELX_P5  AA5 ALA A 88  ? HIS A 92  ? ALA A 88  HIS A 92  5 ? 5  
HELX_P HELX_P6  AA6 ASP A 93  ? LEU A 105 ? ASP A 93  LEU A 105 1 ? 13 
HELX_P HELX_P7  AA7 ASP A 135 ? SER A 139 ? ASP A 135 SER A 139 5 ? 5  
HELX_P HELX_P8  AA8 ASP A 163 ? LYS A 174 ? ASP A 163 LYS A 174 1 ? 12 
HELX_P HELX_P9  AA9 SER A 176 ? PHE A 198 ? SER A 176 PHE A 198 1 ? 23 
HELX_P HELX_P10 AB1 ASP A 201 ? ALA A 205 ? ASP A 201 ALA A 205 5 ? 5  
HELX_P HELX_P11 AB2 LEU A 207 ? PHE A 219 ? LEU A 207 PHE A 219 1 ? 13 
HELX_P HELX_P12 AB3 ASP A 235 ? ASN A 250 ? ASP A 235 ASN A 250 1 ? 16 
HELX_P HELX_P13 AB4 THR A 283 ? ARG A 307 ? THR A 283 ARG A 307 1 ? 25 
HELX_P HELX_P14 AB5 GLU A 309 ? GLY A 322 ? GLU A 309 GLY A 322 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           273 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            273 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    274 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     274 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.96 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? ASN A 59  ? PHE A 55  ASN A 59  
AA1 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA1 3 TYR A 126 ? TYR A 133 ? TYR A 126 TYR A 133 
AA1 4 VAL A 119 ? LYS A 123 ? VAL A 119 LYS A 123 
AA1 5 GLY A 111 ? ILE A 114 ? GLY A 111 ILE A 114 
AA2 1 CYS A 144 ? ALA A 146 ? CYS A 144 ALA A 146 
AA2 2 TRP A 159 ? ILE A 161 ? TRP A 159 ILE A 161 
AA3 1 LYS A 223 ? THR A 225 ? LYS A 223 THR A 225 
AA3 2 VAL A 232 ? TYR A 234 ? VAL A 232 TYR A 234 
AA4 1 PHE A 251 ? ASP A 256 ? PHE A 251 ASP A 256 
AA4 2 ARG A 261 ? LEU A 266 ? ARG A 261 LEU A 266 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 58  ? N PHE A 58  O GLY A 82  ? O GLY A 82  
AA1 2 3 N ILE A 79  ? N ILE A 79  O HIS A 127 ? O HIS A 127 
AA1 3 4 O LEU A 130 ? O LEU A 130 N VAL A 119 ? N VAL A 119 
AA1 4 5 O THR A 120 ? O THR A 120 N GLU A 113 ? N GLU A 113 
AA2 1 2 N ILE A 145 ? N ILE A 145 O GLN A 160 ? O GLN A 160 
AA3 1 2 N ARG A 224 ? N ARG A 224 O THR A 233 ? O THR A 233 
AA4 1 2 N HIS A 252 ? N HIS A 252 O ARG A 265 ? O ARG A 265 
# 
_pdbx_entry_details.entry_id                   8YSI 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 VAL A 4   ? ? 76.22   -5.12  
2 1 PRO A 124 ? ? -46.30  104.58 
3 1 ASP A 163 ? ? -153.34 57.78  
4 1 VAL A 228 ? ? -98.97  -62.26 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 153 ? A GLY 153 
2  1 Y 1 A ASP 154 ? A ASP 154 
3  1 Y 1 A GLU 155 ? A GLU 155 
4  1 Y 1 A HIS 156 ? A HIS 156 
5  1 Y 1 A ASP 331 ? A ASP 331 
6  1 Y 1 A LYS 332 ? A LYS 332 
7  1 Y 1 A SER 333 ? A SER 333 
8  1 Y 1 A ALA 334 ? A ALA 334 
9  1 Y 1 A VAL 335 ? A VAL 335 
10 1 Y 1 A HIS 336 ? A HIS 336 
11 1 Y 1 A THR 337 ? A THR 337 
12 1 Y 1 A ALA 338 ? A ALA 338 
13 1 Y 1 A PRO 339 ? A PRO 339 
14 1 Y 1 A ALA 340 ? A ALA 340 
15 1 Y 1 A ILE 341 ? A ILE 341 
16 1 Y 1 A VAL 342 ? A VAL 342 
17 1 Y 1 A GLY 343 ? A GLY 343 
18 1 Y 1 A SER 344 ? A SER 344 
19 1 Y 1 A GLY 345 ? A GLY 345 
20 1 Y 1 A SER 346 ? A SER 346 
21 1 Y 1 A SER 347 ? A SER 347 
22 1 Y 1 A GLY 348 ? A GLY 348 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
CYS N      N N N 74  
CYS CA     C N R 75  
CYS C      C N N 76  
CYS O      O N N 77  
CYS CB     C N N 78  
CYS SG     S N N 79  
CYS OXT    O N N 80  
CYS H      H N N 81  
CYS H2     H N N 82  
CYS HA     H N N 83  
CYS HB2    H N N 84  
CYS HB3    H N N 85  
CYS HG     H N N 86  
CYS HXT    H N N 87  
GLN N      N N N 88  
GLN CA     C N S 89  
GLN C      C N N 90  
GLN O      O N N 91  
GLN CB     C N N 92  
GLN CG     C N N 93  
GLN CD     C N N 94  
GLN OE1    O N N 95  
GLN NE2    N N N 96  
GLN OXT    O N N 97  
GLN H      H N N 98  
GLN H2     H N N 99  
GLN HA     H N N 100 
GLN HB2    H N N 101 
GLN HB3    H N N 102 
GLN HG2    H N N 103 
GLN HG3    H N N 104 
GLN HE21   H N N 105 
GLN HE22   H N N 106 
GLN HXT    H N N 107 
GLU N      N N N 108 
GLU CA     C N S 109 
GLU C      C N N 110 
GLU O      O N N 111 
GLU CB     C N N 112 
GLU CG     C N N 113 
GLU CD     C N N 114 
GLU OE1    O N N 115 
GLU OE2    O N N 116 
GLU OXT    O N N 117 
GLU H      H N N 118 
GLU H2     H N N 119 
GLU HA     H N N 120 
GLU HB2    H N N 121 
GLU HB3    H N N 122 
GLU HG2    H N N 123 
GLU HG3    H N N 124 
GLU HE2    H N N 125 
GLU HXT    H N N 126 
GLY N      N N N 127 
GLY CA     C N N 128 
GLY C      C N N 129 
GLY O      O N N 130 
GLY OXT    O N N 131 
GLY H      H N N 132 
GLY H2     H N N 133 
GLY HA2    H N N 134 
GLY HA3    H N N 135 
GLY HXT    H N N 136 
HIS N      N N N 137 
HIS CA     C N S 138 
HIS C      C N N 139 
HIS O      O N N 140 
HIS CB     C N N 141 
HIS CG     C Y N 142 
HIS ND1    N Y N 143 
HIS CD2    C Y N 144 
HIS CE1    C Y N 145 
HIS NE2    N Y N 146 
HIS OXT    O N N 147 
HIS H      H N N 148 
HIS H2     H N N 149 
HIS HA     H N N 150 
HIS HB2    H N N 151 
HIS HB3    H N N 152 
HIS HD1    H N N 153 
HIS HD2    H N N 154 
HIS HE1    H N N 155 
HIS HE2    H N N 156 
HIS HXT    H N N 157 
HOH O      O N N 158 
HOH H1     H N N 159 
HOH H2     H N N 160 
ILE N      N N N 161 
ILE CA     C N S 162 
ILE C      C N N 163 
ILE O      O N N 164 
ILE CB     C N S 165 
ILE CG1    C N N 166 
ILE CG2    C N N 167 
ILE CD1    C N N 168 
ILE OXT    O N N 169 
ILE H      H N N 170 
ILE H2     H N N 171 
ILE HA     H N N 172 
ILE HB     H N N 173 
ILE HG12   H N N 174 
ILE HG13   H N N 175 
ILE HG21   H N N 176 
ILE HG22   H N N 177 
ILE HG23   H N N 178 
ILE HD11   H N N 179 
ILE HD12   H N N 180 
ILE HD13   H N N 181 
ILE HXT    H N N 182 
LEU N      N N N 183 
LEU CA     C N S 184 
LEU C      C N N 185 
LEU O      O N N 186 
LEU CB     C N N 187 
LEU CG     C N N 188 
LEU CD1    C N N 189 
LEU CD2    C N N 190 
LEU OXT    O N N 191 
LEU H      H N N 192 
LEU H2     H N N 193 
LEU HA     H N N 194 
LEU HB2    H N N 195 
LEU HB3    H N N 196 
LEU HG     H N N 197 
LEU HD11   H N N 198 
LEU HD12   H N N 199 
LEU HD13   H N N 200 
LEU HD21   H N N 201 
LEU HD22   H N N 202 
LEU HD23   H N N 203 
LEU HXT    H N N 204 
LYS N      N N N 205 
LYS CA     C N S 206 
LYS C      C N N 207 
LYS O      O N N 208 
LYS CB     C N N 209 
LYS CG     C N N 210 
LYS CD     C N N 211 
LYS CE     C N N 212 
LYS NZ     N N N 213 
LYS OXT    O N N 214 
LYS H      H N N 215 
LYS H2     H N N 216 
LYS HA     H N N 217 
LYS HB2    H N N 218 
LYS HB3    H N N 219 
LYS HG2    H N N 220 
LYS HG3    H N N 221 
LYS HD2    H N N 222 
LYS HD3    H N N 223 
LYS HE2    H N N 224 
LYS HE3    H N N 225 
LYS HZ1    H N N 226 
LYS HZ2    H N N 227 
LYS HZ3    H N N 228 
LYS HXT    H N N 229 
MET N      N N N 230 
MET CA     C N S 231 
MET C      C N N 232 
MET O      O N N 233 
MET CB     C N N 234 
MET CG     C N N 235 
MET SD     S N N 236 
MET CE     C N N 237 
MET OXT    O N N 238 
MET H      H N N 239 
MET H2     H N N 240 
MET HA     H N N 241 
MET HB2    H N N 242 
MET HB3    H N N 243 
MET HG2    H N N 244 
MET HG3    H N N 245 
MET HE1    H N N 246 
MET HE2    H N N 247 
MET HE3    H N N 248 
MET HXT    H N N 249 
PHE N      N N N 250 
PHE CA     C N S 251 
PHE C      C N N 252 
PHE O      O N N 253 
PHE CB     C N N 254 
PHE CG     C Y N 255 
PHE CD1    C Y N 256 
PHE CD2    C Y N 257 
PHE CE1    C Y N 258 
PHE CE2    C Y N 259 
PHE CZ     C Y N 260 
PHE OXT    O N N 261 
PHE H      H N N 262 
PHE H2     H N N 263 
PHE HA     H N N 264 
PHE HB2    H N N 265 
PHE HB3    H N N 266 
PHE HD1    H N N 267 
PHE HD2    H N N 268 
PHE HE1    H N N 269 
PHE HE2    H N N 270 
PHE HZ     H N N 271 
PHE HXT    H N N 272 
PRO N      N N N 273 
PRO CA     C N S 274 
PRO C      C N N 275 
PRO O      O N N 276 
PRO CB     C N N 277 
PRO CG     C N N 278 
PRO CD     C N N 279 
PRO OXT    O N N 280 
PRO H      H N N 281 
PRO HA     H N N 282 
PRO HB2    H N N 283 
PRO HB3    H N N 284 
PRO HG2    H N N 285 
PRO HG3    H N N 286 
PRO HD2    H N N 287 
PRO HD3    H N N 288 
PRO HXT    H N N 289 
SER N      N N N 290 
SER CA     C N S 291 
SER C      C N N 292 
SER O      O N N 293 
SER CB     C N N 294 
SER OG     O N N 295 
SER OXT    O N N 296 
SER H      H N N 297 
SER H2     H N N 298 
SER HA     H N N 299 
SER HB2    H N N 300 
SER HB3    H N N 301 
SER HG     H N N 302 
SER HXT    H N N 303 
THR N      N N N 304 
THR CA     C N S 305 
THR C      C N N 306 
THR O      O N N 307 
THR CB     C N R 308 
THR OG1    O N N 309 
THR CG2    C N N 310 
THR OXT    O N N 311 
THR H      H N N 312 
THR H2     H N N 313 
THR HA     H N N 314 
THR HB     H N N 315 
THR HG1    H N N 316 
THR HG21   H N N 317 
THR HG22   H N N 318 
THR HG23   H N N 319 
THR HXT    H N N 320 
TRP N      N N N 321 
TRP CA     C N S 322 
TRP C      C N N 323 
TRP O      O N N 324 
TRP CB     C N N 325 
TRP CG     C Y N 326 
TRP CD1    C Y N 327 
TRP CD2    C Y N 328 
TRP NE1    N Y N 329 
TRP CE2    C Y N 330 
TRP CE3    C Y N 331 
TRP CZ2    C Y N 332 
TRP CZ3    C Y N 333 
TRP CH2    C Y N 334 
TRP OXT    O N N 335 
TRP H      H N N 336 
TRP H2     H N N 337 
TRP HA     H N N 338 
TRP HB2    H N N 339 
TRP HB3    H N N 340 
TRP HD1    H N N 341 
TRP HE1    H N N 342 
TRP HE3    H N N 343 
TRP HZ2    H N N 344 
TRP HZ3    H N N 345 
TRP HH2    H N N 346 
TRP HXT    H N N 347 
TYR N      N N N 348 
TYR CA     C N S 349 
TYR C      C N N 350 
TYR O      O N N 351 
TYR CB     C N N 352 
TYR CG     C Y N 353 
TYR CD1    C Y N 354 
TYR CD2    C Y N 355 
TYR CE1    C Y N 356 
TYR CE2    C Y N 357 
TYR CZ     C Y N 358 
TYR OH     O N N 359 
TYR OXT    O N N 360 
TYR H      H N N 361 
TYR H2     H N N 362 
TYR HA     H N N 363 
TYR HB2    H N N 364 
TYR HB3    H N N 365 
TYR HD1    H N N 366 
TYR HD2    H N N 367 
TYR HE1    H N N 368 
TYR HE2    H N N 369 
TYR HH     H N N 370 
TYR HXT    H N N 371 
UTP PA     P N R 372 
UTP O1A    O N N 373 
UTP O2A    O N N 374 
UTP O3A    O N N 375 
UTP "O5'"  O N N 376 
UTP PB     P N S 377 
UTP O1B    O N N 378 
UTP O2B    O N N 379 
UTP O3B    O N N 380 
UTP PG     P N N 381 
UTP O1G    O N N 382 
UTP O2G    O N N 383 
UTP O3G    O N N 384 
UTP "C5'"  C N N 385 
UTP "C4'"  C N R 386 
UTP "O4'"  O N N 387 
UTP "C1'"  C N R 388 
UTP "C2'"  C N R 389 
UTP "O2'"  O N N 390 
UTP "C3'"  C N S 391 
UTP "O3'"  O N N 392 
UTP N1     N Y N 393 
UTP C6     C Y N 394 
UTP C2     C Y N 395 
UTP O2     O N N 396 
UTP N3     N Y N 397 
UTP C4     C Y N 398 
UTP O4     O N N 399 
UTP C5     C Y N 400 
UTP H2A    H N N 401 
UTP H1B    H N N 402 
UTP H1G    H N N 403 
UTP H3G    H N N 404 
UTP "H5'1" H N N 405 
UTP "H5'2" H N N 406 
UTP "H4'"  H N N 407 
UTP "H1'"  H N N 408 
UTP "H2'"  H N N 409 
UTP HA     H N N 410 
UTP "H3'"  H N N 411 
UTP HB     H N N 412 
UTP H6     H N N 413 
UTP H3     H N N 414 
UTP H5     H N N 415 
VAL N      N N N 416 
VAL CA     C N S 417 
VAL C      C N N 418 
VAL O      O N N 419 
VAL CB     C N N 420 
VAL CG1    C N N 421 
VAL CG2    C N N 422 
VAL OXT    O N N 423 
VAL H      H N N 424 
VAL H2     H N N 425 
VAL HA     H N N 426 
VAL HB     H N N 427 
VAL HG11   H N N 428 
VAL HG12   H N N 429 
VAL HG13   H N N 430 
VAL HG21   H N N 431 
VAL HG22   H N N 432 
VAL HG23   H N N 433 
VAL HXT    H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
GLN N     CA     sing N N 83  
GLN N     H      sing N N 84  
GLN N     H2     sing N N 85  
GLN CA    C      sing N N 86  
GLN CA    CB     sing N N 87  
GLN CA    HA     sing N N 88  
GLN C     O      doub N N 89  
GLN C     OXT    sing N N 90  
GLN CB    CG     sing N N 91  
GLN CB    HB2    sing N N 92  
GLN CB    HB3    sing N N 93  
GLN CG    CD     sing N N 94  
GLN CG    HG2    sing N N 95  
GLN CG    HG3    sing N N 96  
GLN CD    OE1    doub N N 97  
GLN CD    NE2    sing N N 98  
GLN NE2   HE21   sing N N 99  
GLN NE2   HE22   sing N N 100 
GLN OXT   HXT    sing N N 101 
GLU N     CA     sing N N 102 
GLU N     H      sing N N 103 
GLU N     H2     sing N N 104 
GLU CA    C      sing N N 105 
GLU CA    CB     sing N N 106 
GLU CA    HA     sing N N 107 
GLU C     O      doub N N 108 
GLU C     OXT    sing N N 109 
GLU CB    CG     sing N N 110 
GLU CB    HB2    sing N N 111 
GLU CB    HB3    sing N N 112 
GLU CG    CD     sing N N 113 
GLU CG    HG2    sing N N 114 
GLU CG    HG3    sing N N 115 
GLU CD    OE1    doub N N 116 
GLU CD    OE2    sing N N 117 
GLU OE2   HE2    sing N N 118 
GLU OXT   HXT    sing N N 119 
GLY N     CA     sing N N 120 
GLY N     H      sing N N 121 
GLY N     H2     sing N N 122 
GLY CA    C      sing N N 123 
GLY CA    HA2    sing N N 124 
GLY CA    HA3    sing N N 125 
GLY C     O      doub N N 126 
GLY C     OXT    sing N N 127 
GLY OXT   HXT    sing N N 128 
HIS N     CA     sing N N 129 
HIS N     H      sing N N 130 
HIS N     H2     sing N N 131 
HIS CA    C      sing N N 132 
HIS CA    CB     sing N N 133 
HIS CA    HA     sing N N 134 
HIS C     O      doub N N 135 
HIS C     OXT    sing N N 136 
HIS CB    CG     sing N N 137 
HIS CB    HB2    sing N N 138 
HIS CB    HB3    sing N N 139 
HIS CG    ND1    sing Y N 140 
HIS CG    CD2    doub Y N 141 
HIS ND1   CE1    doub Y N 142 
HIS ND1   HD1    sing N N 143 
HIS CD2   NE2    sing Y N 144 
HIS CD2   HD2    sing N N 145 
HIS CE1   NE2    sing Y N 146 
HIS CE1   HE1    sing N N 147 
HIS NE2   HE2    sing N N 148 
HIS OXT   HXT    sing N N 149 
HOH O     H1     sing N N 150 
HOH O     H2     sing N N 151 
ILE N     CA     sing N N 152 
ILE N     H      sing N N 153 
ILE N     H2     sing N N 154 
ILE CA    C      sing N N 155 
ILE CA    CB     sing N N 156 
ILE CA    HA     sing N N 157 
ILE C     O      doub N N 158 
ILE C     OXT    sing N N 159 
ILE CB    CG1    sing N N 160 
ILE CB    CG2    sing N N 161 
ILE CB    HB     sing N N 162 
ILE CG1   CD1    sing N N 163 
ILE CG1   HG12   sing N N 164 
ILE CG1   HG13   sing N N 165 
ILE CG2   HG21   sing N N 166 
ILE CG2   HG22   sing N N 167 
ILE CG2   HG23   sing N N 168 
ILE CD1   HD11   sing N N 169 
ILE CD1   HD12   sing N N 170 
ILE CD1   HD13   sing N N 171 
ILE OXT   HXT    sing N N 172 
LEU N     CA     sing N N 173 
LEU N     H      sing N N 174 
LEU N     H2     sing N N 175 
LEU CA    C      sing N N 176 
LEU CA    CB     sing N N 177 
LEU CA    HA     sing N N 178 
LEU C     O      doub N N 179 
LEU C     OXT    sing N N 180 
LEU CB    CG     sing N N 181 
LEU CB    HB2    sing N N 182 
LEU CB    HB3    sing N N 183 
LEU CG    CD1    sing N N 184 
LEU CG    CD2    sing N N 185 
LEU CG    HG     sing N N 186 
LEU CD1   HD11   sing N N 187 
LEU CD1   HD12   sing N N 188 
LEU CD1   HD13   sing N N 189 
LEU CD2   HD21   sing N N 190 
LEU CD2   HD22   sing N N 191 
LEU CD2   HD23   sing N N 192 
LEU OXT   HXT    sing N N 193 
LYS N     CA     sing N N 194 
LYS N     H      sing N N 195 
LYS N     H2     sing N N 196 
LYS CA    C      sing N N 197 
LYS CA    CB     sing N N 198 
LYS CA    HA     sing N N 199 
LYS C     O      doub N N 200 
LYS C     OXT    sing N N 201 
LYS CB    CG     sing N N 202 
LYS CB    HB2    sing N N 203 
LYS CB    HB3    sing N N 204 
LYS CG    CD     sing N N 205 
LYS CG    HG2    sing N N 206 
LYS CG    HG3    sing N N 207 
LYS CD    CE     sing N N 208 
LYS CD    HD2    sing N N 209 
LYS CD    HD3    sing N N 210 
LYS CE    NZ     sing N N 211 
LYS CE    HE2    sing N N 212 
LYS CE    HE3    sing N N 213 
LYS NZ    HZ1    sing N N 214 
LYS NZ    HZ2    sing N N 215 
LYS NZ    HZ3    sing N N 216 
LYS OXT   HXT    sing N N 217 
MET N     CA     sing N N 218 
MET N     H      sing N N 219 
MET N     H2     sing N N 220 
MET CA    C      sing N N 221 
MET CA    CB     sing N N 222 
MET CA    HA     sing N N 223 
MET C     O      doub N N 224 
MET C     OXT    sing N N 225 
MET CB    CG     sing N N 226 
MET CB    HB2    sing N N 227 
MET CB    HB3    sing N N 228 
MET CG    SD     sing N N 229 
MET CG    HG2    sing N N 230 
MET CG    HG3    sing N N 231 
MET SD    CE     sing N N 232 
MET CE    HE1    sing N N 233 
MET CE    HE2    sing N N 234 
MET CE    HE3    sing N N 235 
MET OXT   HXT    sing N N 236 
PHE N     CA     sing N N 237 
PHE N     H      sing N N 238 
PHE N     H2     sing N N 239 
PHE CA    C      sing N N 240 
PHE CA    CB     sing N N 241 
PHE CA    HA     sing N N 242 
PHE C     O      doub N N 243 
PHE C     OXT    sing N N 244 
PHE CB    CG     sing N N 245 
PHE CB    HB2    sing N N 246 
PHE CB    HB3    sing N N 247 
PHE CG    CD1    doub Y N 248 
PHE CG    CD2    sing Y N 249 
PHE CD1   CE1    sing Y N 250 
PHE CD1   HD1    sing N N 251 
PHE CD2   CE2    doub Y N 252 
PHE CD2   HD2    sing N N 253 
PHE CE1   CZ     doub Y N 254 
PHE CE1   HE1    sing N N 255 
PHE CE2   CZ     sing Y N 256 
PHE CE2   HE2    sing N N 257 
PHE CZ    HZ     sing N N 258 
PHE OXT   HXT    sing N N 259 
PRO N     CA     sing N N 260 
PRO N     CD     sing N N 261 
PRO N     H      sing N N 262 
PRO CA    C      sing N N 263 
PRO CA    CB     sing N N 264 
PRO CA    HA     sing N N 265 
PRO C     O      doub N N 266 
PRO C     OXT    sing N N 267 
PRO CB    CG     sing N N 268 
PRO CB    HB2    sing N N 269 
PRO CB    HB3    sing N N 270 
PRO CG    CD     sing N N 271 
PRO CG    HG2    sing N N 272 
PRO CG    HG3    sing N N 273 
PRO CD    HD2    sing N N 274 
PRO CD    HD3    sing N N 275 
PRO OXT   HXT    sing N N 276 
SER N     CA     sing N N 277 
SER N     H      sing N N 278 
SER N     H2     sing N N 279 
SER CA    C      sing N N 280 
SER CA    CB     sing N N 281 
SER CA    HA     sing N N 282 
SER C     O      doub N N 283 
SER C     OXT    sing N N 284 
SER CB    OG     sing N N 285 
SER CB    HB2    sing N N 286 
SER CB    HB3    sing N N 287 
SER OG    HG     sing N N 288 
SER OXT   HXT    sing N N 289 
THR N     CA     sing N N 290 
THR N     H      sing N N 291 
THR N     H2     sing N N 292 
THR CA    C      sing N N 293 
THR CA    CB     sing N N 294 
THR CA    HA     sing N N 295 
THR C     O      doub N N 296 
THR C     OXT    sing N N 297 
THR CB    OG1    sing N N 298 
THR CB    CG2    sing N N 299 
THR CB    HB     sing N N 300 
THR OG1   HG1    sing N N 301 
THR CG2   HG21   sing N N 302 
THR CG2   HG22   sing N N 303 
THR CG2   HG23   sing N N 304 
THR OXT   HXT    sing N N 305 
TRP N     CA     sing N N 306 
TRP N     H      sing N N 307 
TRP N     H2     sing N N 308 
TRP CA    C      sing N N 309 
TRP CA    CB     sing N N 310 
TRP CA    HA     sing N N 311 
TRP C     O      doub N N 312 
TRP C     OXT    sing N N 313 
TRP CB    CG     sing N N 314 
TRP CB    HB2    sing N N 315 
TRP CB    HB3    sing N N 316 
TRP CG    CD1    doub Y N 317 
TRP CG    CD2    sing Y N 318 
TRP CD1   NE1    sing Y N 319 
TRP CD1   HD1    sing N N 320 
TRP CD2   CE2    doub Y N 321 
TRP CD2   CE3    sing Y N 322 
TRP NE1   CE2    sing Y N 323 
TRP NE1   HE1    sing N N 324 
TRP CE2   CZ2    sing Y N 325 
TRP CE3   CZ3    doub Y N 326 
TRP CE3   HE3    sing N N 327 
TRP CZ2   CH2    doub Y N 328 
TRP CZ2   HZ2    sing N N 329 
TRP CZ3   CH2    sing Y N 330 
TRP CZ3   HZ3    sing N N 331 
TRP CH2   HH2    sing N N 332 
TRP OXT   HXT    sing N N 333 
TYR N     CA     sing N N 334 
TYR N     H      sing N N 335 
TYR N     H2     sing N N 336 
TYR CA    C      sing N N 337 
TYR CA    CB     sing N N 338 
TYR CA    HA     sing N N 339 
TYR C     O      doub N N 340 
TYR C     OXT    sing N N 341 
TYR CB    CG     sing N N 342 
TYR CB    HB2    sing N N 343 
TYR CB    HB3    sing N N 344 
TYR CG    CD1    doub Y N 345 
TYR CG    CD2    sing Y N 346 
TYR CD1   CE1    sing Y N 347 
TYR CD1   HD1    sing N N 348 
TYR CD2   CE2    doub Y N 349 
TYR CD2   HD2    sing N N 350 
TYR CE1   CZ     doub Y N 351 
TYR CE1   HE1    sing N N 352 
TYR CE2   CZ     sing Y N 353 
TYR CE2   HE2    sing N N 354 
TYR CZ    OH     sing N N 355 
TYR OH    HH     sing N N 356 
TYR OXT   HXT    sing N N 357 
UTP PA    O1A    doub N N 358 
UTP PA    O2A    sing N N 359 
UTP PA    O3A    sing N N 360 
UTP PA    "O5'"  sing N N 361 
UTP O2A   H2A    sing N N 362 
UTP O3A   PB     sing N N 363 
UTP "O5'" "C5'"  sing N N 364 
UTP PB    O1B    sing N N 365 
UTP PB    O2B    doub N N 366 
UTP PB    O3B    sing N N 367 
UTP O1B   H1B    sing N N 368 
UTP O3B   PG     sing N N 369 
UTP PG    O1G    sing N N 370 
UTP PG    O2G    doub N N 371 
UTP PG    O3G    sing N N 372 
UTP O1G   H1G    sing N N 373 
UTP O3G   H3G    sing N N 374 
UTP "C5'" "C4'"  sing N N 375 
UTP "C5'" "H5'1" sing N N 376 
UTP "C5'" "H5'2" sing N N 377 
UTP "C4'" "O4'"  sing N N 378 
UTP "C4'" "C3'"  sing N N 379 
UTP "C4'" "H4'"  sing N N 380 
UTP "O4'" "C1'"  sing N N 381 
UTP "C1'" "C2'"  sing N N 382 
UTP "C1'" N1     sing N N 383 
UTP "C1'" "H1'"  sing N N 384 
UTP "C2'" "O2'"  sing N N 385 
UTP "C2'" "C3'"  sing N N 386 
UTP "C2'" "H2'"  sing N N 387 
UTP "O2'" HA     sing N N 388 
UTP "C3'" "O3'"  sing N N 389 
UTP "C3'" "H3'"  sing N N 390 
UTP "O3'" HB     sing N N 391 
UTP N1    C6     sing Y N 392 
UTP N1    C2     sing Y N 393 
UTP C6    C5     doub Y N 394 
UTP C6    H6     sing N N 395 
UTP C2    O2     doub N N 396 
UTP C2    N3     sing Y N 397 
UTP N3    C4     sing Y N 398 
UTP N3    H3     sing N N 399 
UTP C4    O4     doub N N 400 
UTP C4    C5     sing Y N 401 
UTP C5    H5     sing N N 402 
VAL N     CA     sing N N 403 
VAL N     H      sing N N 404 
VAL N     H2     sing N N 405 
VAL CA    C      sing N N 406 
VAL CA    CB     sing N N 407 
VAL CA    HA     sing N N 408 
VAL C     O      doub N N 409 
VAL C     OXT    sing N N 410 
VAL CB    CG1    sing N N 411 
VAL CB    CG2    sing N N 412 
VAL CB    HB     sing N N 413 
VAL CG1   HG11   sing N N 414 
VAL CG1   HG12   sing N N 415 
VAL CG1   HG13   sing N N 416 
VAL CG2   HG21   sing N N 417 
VAL CG2   HG22   sing N N 418 
VAL CG2   HG23   sing N N 419 
VAL OXT   HXT    sing N N 420 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           111-2311-B-039-001-MY3 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'apo DwCdnB' 
# 
_atom_sites.entry_id                    8YSI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028269 
_atom_sites.fract_transf_matrix[1][2]   0.002855 
_atom_sites.fract_transf_matrix[1][3]   0.009526 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.021707 
_atom_sites.fract_transf_matrix[2][3]   0.005489 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.017724 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
P 15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491 68.164 1.115   
S 16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N     . MET A 1 1   ? -2.487  17.585  25.195  1.000 26.856 0 1   MET A N     1 ? 
ATOM   2    C CA    . MET A 1 1   ? -1.939  16.961  23.896  1.000 25.101 0 1   MET A CA    1 ? 
ATOM   3    C C     . MET A 1 1   ? -0.613  16.283  24.217  1.000 23.470 0 1   MET A C     1 ? 
ATOM   4    O O     . MET A 1 1   ? 0.196   16.880  24.965  1.000 24.389 0 1   MET A O     1 ? 
ATOM   5    C CB    . MET A 1 1   ? -1.690  17.988  22.785  1.000 28.537 0 1   MET A CB    1 ? 
ATOM   6    C CG    . MET A 1 1   ? -2.343  17.581  21.447  1.000 35.037 0 1   MET A CG    1 ? 
ATOM   7    S SD    . MET A 1 1   ? -1.758  18.533  20.028  1.000 42.416 0 1   MET A SD    1 ? 
ATOM   8    C CE    . MET A 1 1   ? -2.673  20.035  20.313  1.000 40.547 0 1   MET A CE    1 ? 
ATOM   9    N N     . ALA A 1 2   ? -0.404  15.074  23.738  1.000 20.685 0 2   ALA A N     1 ? 
ATOM   10   C CA    . ALA A 1 2   ? 0.829   14.299  24.032  1.000 21.171 0 2   ALA A CA    1 ? 
ATOM   11   C C     . ALA A 1 2   ? 2.022   15.033  23.417  1.000 23.093 0 2   ALA A C     1 ? 
ATOM   12   O O     . ALA A 1 2   ? 1.896   15.628  22.345  1.000 20.364 0 2   ALA A O     1 ? 
ATOM   13   C CB    . ALA A 1 2   ? 0.690   12.908  23.508  1.000 23.513 0 2   ALA A CB    1 ? 
ATOM   14   N N     . PRO A 1 3   ? 3.198   15.112  24.091  1.000 26.402 0 3   PRO A N     1 ? 
ATOM   15   C CA    . PRO A 1 3   ? 4.445   15.440  23.405  1.000 25.936 0 3   PRO A CA    1 ? 
ATOM   16   C C     . PRO A 1 3   ? 4.564   14.723  22.039  1.000 21.538 0 3   PRO A C     1 ? 
ATOM   17   O O     . PRO A 1 3   ? 4.100   13.567  21.857  1.000 20.621 0 3   PRO A O     1 ? 
ATOM   18   C CB    . PRO A 1 3   ? 5.552   14.974  24.386  1.000 30.004 0 3   PRO A CB    1 ? 
ATOM   19   C CG    . PRO A 1 3   ? 4.770   14.243  25.520  1.000 33.046 0 3   PRO A CG    1 ? 
ATOM   20   C CD    . PRO A 1 3   ? 3.415   14.921  25.538  1.000 29.410 0 3   PRO A CD    1 ? 
ATOM   21   N N     . VAL A 1 4   ? 5.033   15.503  21.083  1.000 17.326 0 4   VAL A N     1 ? 
ATOM   22   C CA    . VAL A 1 4   ? 5.356   15.146  19.671  1.000 16.221 0 4   VAL A CA    1 ? 
ATOM   23   C C     . VAL A 1 4   ? 4.082   15.011  18.832  1.000 13.255 0 4   VAL A C     1 ? 
ATOM   24   O O     . VAL A 1 4   ? 4.242   14.903  17.579  1.000 10.742 0 4   VAL A O     1 ? 
ATOM   25   C CB    . VAL A 1 4   ? 6.312   13.932  19.560  1.000 19.176 0 4   VAL A CB    1 ? 
ATOM   26   C CG1   . VAL A 1 4   ? 7.427   14.027  20.606  1.000 21.182 0 4   VAL A CG1   1 ? 
ATOM   27   C CG2   . VAL A 1 4   ? 5.624   12.606  19.675  1.000 23.141 0 4   VAL A CG2   1 ? 
ATOM   28   N N     . GLN A 1 5   ? 2.865   15.109  19.420  1.000 12.283 0 5   GLN A N     1 ? 
ATOM   29   C CA    . GLN A 1 5   ? 1.635   14.996  18.606  1.000 12.212 0 5   GLN A CA    1 ? 
ATOM   30   C C     . GLN A 1 5   ? 1.586   16.116  17.550  1.000 11.790 0 5   GLN A C     1 ? 
ATOM   31   O O     . GLN A 1 5   ? 1.312   15.830  16.373  1.000 11.730 0 5   GLN A O     1 ? 
ATOM   32   C CB    . GLN A 1 5   ? 0.371   15.014  19.443  1.000 12.440 0 5   GLN A CB    1 ? 
ATOM   33   C CG    . GLN A 1 5   ? -0.893  14.740  18.616  1.000 11.933 0 5   GLN A CG    1 ? 
ATOM   34   C CD    . GLN A 1 5   ? -0.957  13.395  17.907  1.000 12.278 0 5   GLN A CD    1 ? 
ATOM   35   O OE1   . GLN A 1 5   ? -0.168  12.470  18.138  1.000 11.079 0 5   GLN A OE1   1 ? 
ATOM   36   N NE2   . GLN A 1 5   ? -2.006  13.214  17.126  1.000 11.624 0 5   GLN A NE2   1 ? 
ATOM   37   N N     . LYS A 1 6   ? 1.892   17.344  17.930  1.000 12.203 0 6   LYS A N     1 ? 
ATOM   38   C CA    . LYS A 1 6   ? 1.879   18.475  16.982  1.000 12.910 0 6   LYS A CA    1 ? 
ATOM   39   C C     . LYS A 1 6   ? 2.767   18.152  15.774  1.000 11.632 0 6   LYS A C     1 ? 
ATOM   40   O O     . LYS A 1 6   ? 2.331   18.319  14.628  1.000 10.810 0 6   LYS A O     1 ? 
ATOM   41   C CB    . LYS A 1 6   ? 2.375   19.762  17.619  1.000 14.781 0 6   LYS A CB    1 ? 
ATOM   42   C CG    . LYS A 1 6   ? 2.325   20.918  16.644  1.000 17.882 0 6   LYS A CG    1 ? 
ATOM   43   C CD    . LYS A 1 6   ? 2.659   22.244  17.231  1.000 22.619 0 6   LYS A CD    1 ? 
ATOM   44   C CE    . LYS A 1 6   ? 2.507   23.325  16.191  1.000 25.865 0 6   LYS A CE    1 ? 
ATOM   45   N NZ    . LYS A 1 6   ? 3.413   24.445  16.475  1.000 33.467 0 6   LYS A NZ    1 ? 
ATOM   46   N N     . GLN A 1 7   ? 3.952   17.600  16.019  1.000 11.223 0 7   GLN A N     1 ? 
ATOM   47   C CA    . GLN A 1 7   ? 4.958   17.345  14.959  1.000 11.150 0 7   GLN A CA    1 ? 
ATOM   48   C C     . GLN A 1 7   ? 4.557   16.133  14.115  1.000 11.000 0 7   GLN A C     1 ? 
ATOM   49   O O     . GLN A 1 7   ? 4.770   16.194  12.911  1.000 11.081 0 7   GLN A O     1 ? 
ATOM   50   C CB    . GLN A 1 7   ? 6.345   17.170  15.585  1.000 11.477 0 7   GLN A CB    1 ? 
ATOM   51   C CG    . GLN A 1 7   ? 6.958   18.474  16.118  1.000 12.307 0 7   GLN A CG    1 ? 
ATOM   52   C CD    . GLN A 1 7   ? 6.325   19.003  17.365  1.000 12.204 0 7   GLN A CD    1 ? 
ATOM   53   O OE1   . GLN A 1 7   ? 5.972   18.255  18.263  1.000 13.853 0 7   GLN A OE1   1 ? 
ATOM   54   N NE2   . GLN A 1 7   ? 6.121   20.307  17.405  1.000 12.665 0 7   GLN A NE2   1 ? 
ATOM   55   N N     . PHE A 1 8   ? 3.968   15.076  14.692  1.000 11.070 0 8   PHE A N     1 ? 
ATOM   56   C CA    . PHE A 1 8   ? 3.355   13.989  13.885  1.000 10.329 0 8   PHE A CA    1 ? 
ATOM   57   C C     . PHE A 1 8   ? 2.305   14.559  12.950  1.000 10.255 0 8   PHE A C     1 ? 
ATOM   58   O O     . PHE A 1 8   ? 2.292   14.161  11.761  1.000 8.963  0 8   PHE A O     1 ? 
ATOM   59   C CB    . PHE A 1 8   ? 2.761   12.871  14.730  1.000 10.434 0 8   PHE A CB    1 ? 
ATOM   60   C CG    . PHE A 1 8   ? 3.749   11.785  14.992  1.000 10.872 0 8   PHE A CG    1 ? 
ATOM   61   C CD1   . PHE A 1 8   ? 4.116   10.932  13.972  1.000 10.715 0 8   PHE A CD1   1 ? 
ATOM   62   C CD2   . PHE A 1 8   ? 4.323   11.638  16.237  1.000 10.319 0 8   PHE A CD2   1 ? 
ATOM   63   C CE1   . PHE A 1 8   ? 5.020   9.904   14.204  1.000 11.197 0 8   PHE A CE1   1 ? 
ATOM   64   C CE2   . PHE A 1 8   ? 5.294   10.663  16.443  1.000 12.025 0 8   PHE A CE2   1 ? 
ATOM   65   C CZ    . PHE A 1 8   ? 5.654   9.810   15.424  1.000 11.001 0 8   PHE A CZ    1 ? 
ATOM   66   N N     . ARG A 1 9   ? 1.424   15.432  13.434  1.000 11.039 0 9   ARG A N     1 ? 
ATOM   67   C CA    . ARG A 1 9   ? 0.335   15.974  12.564  1.000 11.221 0 9   ARG A CA    1 ? 
ATOM   68   C C     . ARG A 1 9   ? 0.941   16.841  11.466  1.000 11.517 0 9   ARG A C     1 ? 
ATOM   69   O O     . ARG A 1 9   ? 0.422   16.795  10.346  1.000 12.596 0 9   ARG A O     1 ? 
ATOM   70   C CB    . ARG A 1 9   ? -0.733  16.726  13.361  1.000 12.430 0 9   ARG A CB    1 ? 
ATOM   71   C CG    . ARG A 1 9   ? -1.498  15.839  14.325  1.000 12.686 0 9   ARG A CG    1 ? 
ATOM   72   C CD    . ARG A 1 9   ? -2.275  14.695  13.730  1.000 13.479 0 9   ARG A CD    1 ? 
ATOM   73   N NE    . ARG A 1 9   ? -3.245  15.101  12.724  1.000 13.312 0 9   ARG A NE    1 ? 
ATOM   74   C CZ    . ARG A 1 9   ? -4.537  15.324  12.960  1.000 14.580 0 9   ARG A CZ    1 ? 
ATOM   75   N NH1   . ARG A 1 9   ? -5.026  15.234  14.177  1.000 13.491 0 9   ARG A NH1   1 ? 
ATOM   76   N NH2   . ARG A 1 9   ? -5.337  15.683  11.969  1.000 16.916 0 9   ARG A NH2   1 ? 
ATOM   77   N N     . GLU A 1 10  ? 1.999   17.594  11.750  1.000 11.190 0 10  GLU A N     1 ? 
ATOM   78   C CA    . GLU A 1 10  ? 2.692   18.394  10.717  1.000 12.740 0 10  GLU A CA    1 ? 
ATOM   79   C C     . GLU A 1 10  ? 3.349   17.464  9.699   1.000 11.474 0 10  GLU A C     1 ? 
ATOM   80   O O     . GLU A 1 10  ? 3.293   17.768  8.521   1.000 12.015 0 10  GLU A O     1 ? 
ATOM   81   C CB    . GLU A 1 10  ? 3.713   19.325  11.348  1.000 13.661 0 10  GLU A CB    1 ? 
ATOM   82   C CG    . GLU A 1 10  ? 3.064   20.433  12.138  1.000 16.666 0 10  GLU A CG    1 ? 
ATOM   83   C CD    . GLU A 1 10  ? 4.024   21.318  12.906  1.000 21.098 0 10  GLU A CD    1 ? 
ATOM   84   O OE1   . GLU A 1 10  ? 5.143   20.895  13.167  1.000 21.525 0 10  GLU A OE1   1 ? 
ATOM   85   O OE2   . GLU A 1 10  ? 3.571   22.348  13.373  1.000 29.476 0 10  GLU A OE2   1 ? 
ATOM   86   N N     . PHE A 1 11  ? 3.993   16.401  10.157  1.000 10.031 0 11  PHE A N     1 ? 
ATOM   87   C CA    . PHE A 1 11  ? 4.608   15.375  9.270   1.000 10.606 0 11  PHE A CA    1 ? 
ATOM   88   C C     . PHE A 1 11  ? 3.530   14.812  8.349   1.000 10.081 0 11  PHE A C     1 ? 
ATOM   89   O O     . PHE A 1 11  ? 3.716   14.744  7.105   1.000 10.279 0 11  PHE A O     1 ? 
ATOM   90   C CB    . PHE A 1 11  ? 5.283   14.320  10.140  1.000 10.177 0 11  PHE A CB    1 ? 
ATOM   91   C CG    . PHE A 1 11  ? 5.900   13.177  9.395   1.000 10.635 0 11  PHE A CG    1 ? 
ATOM   92   C CD1   . PHE A 1 11  ? 6.819   13.393  8.369   1.000 10.814 0 11  PHE A CD1   1 ? 
ATOM   93   C CD2   . PHE A 1 11  ? 5.567   11.872  9.738   1.000 11.331 0 11  PHE A CD2   1 ? 
ATOM   94   C CE1   . PHE A 1 11  ? 7.360   12.315  7.685   1.000 11.414 0 11  PHE A CE1   1 ? 
ATOM   95   C CE2   . PHE A 1 11  ? 6.166   10.799  9.094   1.000 11.022 0 11  PHE A CE2   1 ? 
ATOM   96   C CZ    . PHE A 1 11  ? 7.016   11.017  8.038   1.000 11.351 0 11  PHE A CZ    1 ? 
ATOM   97   N N     . HIS A 1 12  ? 2.402   14.420  8.937   1.000 10.515 0 12  HIS A N     1 ? 
ATOM   98   C CA    . HIS A 1 12  ? 1.242   13.881  8.177   1.000 11.146 0 12  HIS A CA    1 ? 
ATOM   99   C C     . HIS A 1 12  ? 0.831   14.845  7.057   1.000 12.128 0 12  HIS A C     1 ? 
ATOM   100  O O     . HIS A 1 12  ? 0.654   14.396  5.867   1.000 11.584 0 12  HIS A O     1 ? 
ATOM   101  C CB    . HIS A 1 12  ? 0.069   13.551  9.105   1.000 11.178 0 12  HIS A CB    1 ? 
ATOM   102  C CG    . HIS A 1 12  ? -0.998  12.854  8.336   1.000 11.050 0 12  HIS A CG    1 ? 
ATOM   103  N ND1   . HIS A 1 12  ? -2.192  13.462  8.025   1.000 12.737 0 12  HIS A ND1   1 ? 
ATOM   104  C CD2   . HIS A 1 12  ? -0.982  11.685  7.659   1.000 12.075 0 12  HIS A CD2   1 ? 
ATOM   105  C CE1   . HIS A 1 12  ? -2.896  12.656  7.242   1.000 11.089 0 12  HIS A CE1   1 ? 
ATOM   106  N NE2   . HIS A 1 12  ? -2.198  11.568  7.024   1.000 11.801 0 12  HIS A NE2   1 ? 
ATOM   107  N N     . ASP A 1 13  ? 0.675   16.119  7.397   1.000 14.015 0 13  ASP A N     1 ? 
ATOM   108  C CA    . ASP A 1 13  ? 0.301   17.181  6.433   1.000 15.700 0 13  ASP A CA    1 ? 
ATOM   109  C C     . ASP A 1 13  ? 1.280   17.211  5.253   1.000 14.845 0 13  ASP A C     1 ? 
ATOM   110  O O     . ASP A 1 13  ? 0.825   17.388  4.122   1.000 15.147 0 13  ASP A O     1 ? 
ATOM   111  C CB    . ASP A 1 13  ? 0.216   18.530  7.122   1.000 17.742 0 13  ASP A CB    1 ? 
ATOM   112  C CG    . ASP A 1 13  ? -0.994  18.721  8.017   1.000 21.258 0 13  ASP A CG    1 ? 
ATOM   113  O OD1   . ASP A 1 13  ? -1.931  17.909  7.930   1.000 24.066 0 13  ASP A OD1   1 ? 
ATOM   114  O OD2   . ASP A 1 13  ? -0.929  19.627  8.858   1.000 28.050 0 13  ASP A OD2   1 ? 
ATOM   115  N N     . ARG A 1 14  ? 2.567   16.992  5.495   1.000 14.298 0 14  ARG A N     1 ? 
ATOM   116  C CA    . ARG A 1 14  ? 3.634   17.075  4.475   1.000 15.498 0 14  ARG A CA    1 ? 
ATOM   117  C C     . ARG A 1 14  ? 3.702   15.809  3.609   1.000 14.739 0 14  ARG A C     1 ? 
ATOM   118  O O     . ARG A 1 14  ? 4.312   15.895  2.535   1.000 15.895 0 14  ARG A O     1 ? 
ATOM   119  C CB    . ARG A 1 14  ? 4.981   17.320  5.155   1.000 17.333 0 14  ARG A CB    1 ? 
ATOM   120  C CG    . ARG A 1 14  ? 5.125   18.739  5.691   1.000 19.028 0 14  ARG A CG    1 ? 
ATOM   121  C CD    . ARG A 1 14  ? 6.129   18.878  6.823   1.000 20.692 0 14  ARG A CD    1 ? 
ATOM   122  N NE    . ARG A 1 14  ? 6.329   20.291  7.077   1.000 23.718 0 14  ARG A NE    1 ? 
ATOM   123  C CZ    . ARG A 1 14  ? 5.473   21.062  7.726   1.000 23.560 0 14  ARG A CZ    1 ? 
ATOM   124  N NH1   . ARG A 1 14  ? 4.354   20.552  8.228   1.000 23.248 0 14  ARG A NH1   1 ? 
ATOM   125  N NH2   . ARG A 1 14  ? 5.710   22.350  7.823   1.000 22.541 0 14  ARG A NH2   1 ? 
ATOM   126  N N     . ILE A 1 15  ? 3.247   14.644  4.094   1.000 12.714 0 15  ILE A N     1 ? 
ATOM   127  C CA    . ILE A 1 15  ? 3.425   13.358  3.355   1.000 12.577 0 15  ILE A CA    1 ? 
ATOM   128  C C     . ILE A 1 15  ? 2.127   12.921  2.680   1.000 12.688 0 15  ILE A C     1 ? 
ATOM   129  O O     . ILE A 1 15  ? 2.213   12.151  1.708   1.000 13.896 0 15  ILE A O     1 ? 
ATOM   130  C CB    . ILE A 1 15  ? 3.988   12.240  4.247   1.000 11.069 0 15  ILE A CB    1 ? 
ATOM   131  C CG1   . ILE A 1 15  ? 2.990   11.771  5.289   1.000 10.444 0 15  ILE A CG1   1 ? 
ATOM   132  C CG2   . ILE A 1 15  ? 5.294   12.639  4.864   1.000 10.534 0 15  ILE A CG2   1 ? 
ATOM   133  C CD1   . ILE A 1 15  ? 3.463   10.528  6.060   1.000 11.005 0 15  ILE A CD1   1 ? 
ATOM   134  N N     . LYS A 1 16  ? 0.976   13.396  3.142   1.000 13.541 0 16  LYS A N     1 ? 
ATOM   135  C CA    . LYS A 1 16  ? -0.321  12.941  2.633   1.000 16.328 0 16  LYS A CA    1 ? 
ATOM   136  C C     . LYS A 1 16  ? -0.465  13.345  1.164   1.000 16.340 0 16  LYS A C     1 ? 
ATOM   137  O O     . LYS A 1 16  ? -0.117  14.467  0.801   1.000 16.293 0 16  LYS A O     1 ? 
ATOM   138  C CB    . LYS A 1 16  ? -1.475  13.454  3.488   1.000 19.344 0 16  LYS A CB    1 ? 
ATOM   139  C CG    . LYS A 1 16  ? -1.751  14.943  3.393   1.000 24.589 0 16  LYS A CG    1 ? 
ATOM   140  C CD    . LYS A 1 16  ? -2.705  15.406  4.476   1.000 30.319 0 16  LYS A CD    1 ? 
ATOM   141  C CE    . LYS A 1 16  ? -3.130  16.855  4.338   1.000 31.370 0 16  LYS A CE    1 ? 
ATOM   142  N NZ    . LYS A 1 16  ? -4.015  17.231  5.459   1.000 32.672 0 16  LYS A NZ    1 ? 
ATOM   143  N N     . LEU A 1 17  ? -1.021  12.455  0.375   1.000 16.391 0 17  LEU A N     1 ? 
ATOM   144  C CA    . LEU A 1 17  ? -1.491  12.757  -0.997  1.000 19.329 0 17  LEU A CA    1 ? 
ATOM   145  C C     . LEU A 1 17  ? -3.012  12.596  -1.021  1.000 20.438 0 17  LEU A C     1 ? 
ATOM   146  O O     . LEU A 1 17  ? -3.474  11.525  -0.605  1.000 18.919 0 17  LEU A O     1 ? 
ATOM   147  C CB    . LEU A 1 17  ? -0.808  11.781  -1.956  1.000 20.790 0 17  LEU A CB    1 ? 
ATOM   148  C CG    . LEU A 1 17  ? -1.079  12.018  -3.437  1.000 23.725 0 17  LEU A CG    1 ? 
ATOM   149  C CD1   . LEU A 1 17  ? -0.675  13.431  -3.861  1.000 25.172 0 17  LEU A CD1   1 ? 
ATOM   150  C CD2   . LEU A 1 17  ? -0.347  10.976  -4.278  1.000 24.080 0 17  LEU A CD2   1 ? 
ATOM   151  N N     . ALA A 1 18  ? -3.755  13.600  -1.504  1.000 18.412 0 18  ALA A N     1 ? 
ATOM   152  C CA    . ALA A 1 18  ? -5.241  13.568  -1.604  1.000 20.628 0 18  ALA A CA    1 ? 
ATOM   153  C C     . ALA A 1 18  ? -5.720  12.365  -2.443  1.000 20.532 0 18  ALA A C     1 ? 
ATOM   154  O O     . ALA A 1 18  ? -5.154  12.107  -3.494  1.000 23.857 0 18  ALA A O     1 ? 
ATOM   155  C CB    . ALA A 1 18  ? -5.765  14.856  -2.188  1.000 21.722 0 18  ALA A CB    1 ? 
ATOM   156  N N     . GLN A 1 19  ? -6.752  11.677  -1.960  1.000 22.287 0 19  GLN A N     1 ? 
ATOM   157  C CA    . GLN A 1 19  ? -7.345  10.457  -2.568  1.000 22.833 0 19  GLN A CA    1 ? 
ATOM   158  C C     . GLN A 1 19  ? -8.069  10.837  -3.870  1.000 23.299 0 19  GLN A C     1 ? 
ATOM   159  O O     . GLN A 1 19  ? -8.296  12.076  -4.133  1.000 20.074 0 19  GLN A O     1 ? 
ATOM   160  C CB    . GLN A 1 19  ? -8.311  9.806   -1.582  1.000 23.251 0 19  GLN A CB    1 ? 
ATOM   161  C CG    . GLN A 1 19  ? -9.468  10.714  -1.174  1.000 25.990 0 19  GLN A CG    1 ? 
ATOM   162  C CD    . GLN A 1 19  ? -10.562 9.983   -0.451  1.000 26.437 0 19  GLN A CD    1 ? 
ATOM   163  O OE1   . GLN A 1 19  ? -10.891 8.851   -0.783  1.000 29.597 0 19  GLN A OE1   1 ? 
ATOM   164  N NE2   . GLN A 1 19  ? -11.135 10.630  0.547   1.000 27.613 0 19  GLN A NE2   1 ? 
ATOM   165  N N     . TYR A 1 20  ? -8.497  9.841   -4.636  1.000 21.806 0 20  TYR A N     1 ? 
ATOM   166  C CA    . TYR A 1 20  ? -9.099  10.075  -5.983  1.000 22.667 0 20  TYR A CA    1 ? 
ATOM   167  C C     . TYR A 1 20  ? -10.190 11.158  -5.896  1.000 22.862 0 20  TYR A C     1 ? 
ATOM   168  O O     . TYR A 1 20  ? -10.080 12.157  -6.639  1.000 25.082 0 20  TYR A O     1 ? 
ATOM   169  C CB    . TYR A 1 20  ? -9.634  8.766   -6.550  1.000 20.173 0 20  TYR A CB    1 ? 
ATOM   170  C CG    . TYR A 1 20  ? -8.595  7.888   -7.188  1.000 22.672 0 20  TYR A CG    1 ? 
ATOM   171  C CD1   . TYR A 1 20  ? -7.728  8.382   -8.146  1.000 21.645 0 20  TYR A CD1   1 ? 
ATOM   172  C CD2   . TYR A 1 20  ? -8.498  6.546   -6.859  1.000 21.754 0 20  TYR A CD2   1 ? 
ATOM   173  C CE1   . TYR A 1 20  ? -6.820  7.574   -8.786  1.000 23.210 0 20  TYR A CE1   1 ? 
ATOM   174  C CE2   . TYR A 1 20  ? -7.562  5.732   -7.463  1.000 22.854 0 20  TYR A CE2   1 ? 
ATOM   175  C CZ    . TYR A 1 20  ? -6.728  6.238   -8.441  1.000 24.188 0 20  TYR A CZ    1 ? 
ATOM   176  O OH    . TYR A 1 20  ? -5.807  5.429   -9.057  1.000 28.260 0 20  TYR A OH    1 ? 
ATOM   177  N N     . ASP A 1 21  ? -11.161 10.991  -4.991  1.000 25.640 0 21  ASP A N     1 ? 
ATOM   178  C CA    . ASP A 1 21  ? -12.379 11.843  -4.852  1.000 29.607 0 21  ASP A CA    1 ? 
ATOM   179  C C     . ASP A 1 21  ? -12.007 13.294  -4.474  1.000 30.603 0 21  ASP A C     1 ? 
ATOM   180  O O     . ASP A 1 21  ? -12.887 14.159  -4.584  1.000 28.695 0 21  ASP A O     1 ? 
ATOM   181  C CB    . ASP A 1 21  ? -13.368 11.305  -3.807  1.000 33.010 0 21  ASP A CB    1 ? 
ATOM   182  C CG    . ASP A 1 21  ? -14.007 9.955   -4.119  1.000 37.969 0 21  ASP A CG    1 ? 
ATOM   183  O OD1   . ASP A 1 21  ? -14.637 9.381   -3.197  1.000 42.832 0 21  ASP A OD1   1 ? 
ATOM   184  O OD2   . ASP A 1 21  ? -13.855 9.466   -5.255  1.000 41.288 0 21  ASP A OD2   1 ? 
ATOM   185  N N     . GLU A 1 22  ? -10.781 13.561  -4.014  1.000 28.166 0 22  GLU A N     1 ? 
ATOM   186  C CA    . GLU A 1 22  ? -10.396 14.921  -3.554  1.000 32.779 0 22  GLU A CA    1 ? 
ATOM   187  C C     . GLU A 1 22  ? -9.240  15.438  -4.396  1.000 30.154 0 22  GLU A C     1 ? 
ATOM   188  O O     . GLU A 1 22  ? -8.658  16.438  -3.997  1.000 32.730 0 22  GLU A O     1 ? 
ATOM   189  C CB    . GLU A 1 22  ? -9.970  14.925  -2.081  1.000 31.121 0 22  GLU A CB    1 ? 
ATOM   190  C CG    . GLU A 1 22  ? -10.997 14.393  -1.116  1.000 31.471 0 22  GLU A CG    1 ? 
ATOM   191  C CD    . GLU A 1 22  ? -10.546 14.526  0.330   1.000 35.630 0 22  GLU A CD    1 ? 
ATOM   192  O OE1   . GLU A 1 22  ? -10.369 15.664  0.781   1.000 42.573 0 22  GLU A OE1   1 ? 
ATOM   193  O OE2   . GLU A 1 22  ? -10.306 13.504  0.983   1.000 38.514 0 22  GLU A OE2   1 ? 
ATOM   194  N N     . ASN A 1 23  ? -8.884  14.742  -5.482  1.000 31.512 0 23  ASN A N     1 ? 
ATOM   195  C CA    . ASN A 1 23  ? -7.632  14.987  -6.250  1.000 30.649 0 23  ASN A CA    1 ? 
ATOM   196  C C     . ASN A 1 23  ? -7.913  14.948  -7.762  1.000 32.921 0 23  ASN A C     1 ? 
ATOM   197  O O     . ASN A 1 23  ? -7.718  13.877  -8.380  1.000 29.269 0 23  ASN A O     1 ? 
ATOM   198  C CB    . ASN A 1 23  ? -6.539  14.010  -5.851  1.000 28.569 0 23  ASN A CB    1 ? 
ATOM   199  C CG    . ASN A 1 23  ? -5.152  14.440  -6.284  1.000 29.981 0 23  ASN A CG    1 ? 
ATOM   200  O OD1   . ASN A 1 23  ? -4.959  15.031  -7.355  1.000 30.121 0 23  ASN A OD1   1 ? 
ATOM   201  N ND2   . ASN A 1 23  ? -4.158  14.084  -5.480  1.000 27.428 0 23  ASN A ND2   1 ? 
ATOM   202  N N     . GLN A 1 24  ? -8.225  16.118  -8.340  1.000 33.874 0 24  GLN A N     1 ? 
ATOM   203  C CA    . GLN A 1 24  ? -8.574  16.318  -9.781  1.000 34.508 0 24  GLN A CA    1 ? 
ATOM   204  C C     . GLN A 1 24  ? -7.470  15.789  -10.698 1.000 33.774 0 24  GLN A C     1 ? 
ATOM   205  O O     . GLN A 1 24  ? -7.796  15.177  -11.751 1.000 38.831 0 24  GLN A O     1 ? 
ATOM   206  C CB    . GLN A 1 24  ? -8.779  17.811  -10.049 1.000 41.499 0 24  GLN A CB    1 ? 
ATOM   207  C CG    . GLN A 1 24  ? -9.118  18.135  -11.495 1.000 48.665 0 24  GLN A CG    1 ? 
ATOM   208  C CD    . GLN A 1 24  ? -10.349 17.386  -11.927 1.000 50.651 0 24  GLN A CD    1 ? 
ATOM   209  O OE1   . GLN A 1 24  ? -10.264 16.296  -12.489 1.000 52.330 0 24  GLN A OE1   1 ? 
ATOM   210  N NE2   . GLN A 1 24  ? -11.506 17.946  -11.610 1.000 54.357 0 24  GLN A NE2   1 ? 
ATOM   211  N N     . THR A 1 25  ? -6.209  16.057  -10.355 1.000 34.634 0 25  THR A N     1 ? 
ATOM   212  C CA    . THR A 1 25  ? -5.005  15.669  -11.139 1.000 34.080 0 25  THR A CA    1 ? 
ATOM   213  C C     . THR A 1 25  ? -4.928  14.140  -11.292 1.000 34.292 0 25  THR A C     1 ? 
ATOM   214  O O     . THR A 1 25  ? -4.607  13.671  -12.397 1.000 31.144 0 25  THR A O     1 ? 
ATOM   215  C CB    . THR A 1 25  ? -3.737  16.213  -10.471 1.000 38.579 0 25  THR A CB    1 ? 
ATOM   216  O OG1   . THR A 1 25  ? -3.984  17.584  -10.168 1.000 44.268 0 25  THR A OG1   1 ? 
ATOM   217  C CG2   . THR A 1 25  ? -2.498  16.080  -11.325 1.000 40.222 0 25  THR A CG2   1 ? 
ATOM   218  N N     . LEU A 1 26  ? -5.105  13.389  -10.200 1.000 32.911 0 26  LEU A N     1 ? 
ATOM   219  C CA    . LEU A 1 26  ? -5.008  11.904  -10.236 1.000 30.194 0 26  LEU A CA    1 ? 
ATOM   220  C C     . LEU A 1 26  ? -6.150  11.376  -11.102 1.000 27.410 0 26  LEU A C     1 ? 
ATOM   221  O O     . LEU A 1 26  ? -5.894  10.454  -11.941 1.000 26.842 0 26  LEU A O     1 ? 
ATOM   222  C CB    . LEU A 1 26  ? -5.057  11.314  -8.823  1.000 27.034 0 26  LEU A CB    1 ? 
ATOM   223  C CG    . LEU A 1 26  ? -3.789  11.500  -7.981  1.000 28.466 0 26  LEU A CG    1 ? 
ATOM   224  C CD1   . LEU A 1 26  ? -3.941  10.818  -6.629  1.000 29.426 0 26  LEU A CD1   1 ? 
ATOM   225  C CD2   . LEU A 1 26  ? -2.547  10.983  -8.699  1.000 27.962 0 26  LEU A CD2   1 ? 
ATOM   226  N N     . ARG A 1 27  ? -7.340  11.950  -10.939 1.000 25.679 0 27  ARG A N     1 ? 
ATOM   227  C CA    . ARG A 1 27  ? -8.545  11.509  -11.692 1.000 30.839 0 27  ARG A CA    1 ? 
ATOM   228  C C     . ARG A 1 27  ? -8.252  11.630  -13.195 1.000 33.434 0 27  ARG A C     1 ? 
ATOM   229  O O     . ARG A 1 27  ? -8.542  10.662  -13.917 1.000 33.385 0 27  ARG A O     1 ? 
ATOM   230  C CB    . ARG A 1 27  ? -9.793  12.287  -11.269 1.000 28.483 0 27  ARG A CB    1 ? 
ATOM   231  C CG    . ARG A 1 27  ? -10.345 11.877  -9.911  1.000 30.518 0 27  ARG A CG    1 ? 
ATOM   232  C CD    . ARG A 1 27  ? -11.778 12.281  -9.663  1.000 30.588 0 27  ARG A CD    1 ? 
ATOM   233  N NE    . ARG A 1 27  ? -12.015 13.688  -9.927  1.000 33.929 0 27  ARG A NE    1 ? 
ATOM   234  C CZ    . ARG A 1 27  ? -11.828 14.682  -9.053  1.000 38.381 0 27  ARG A CZ    1 ? 
ATOM   235  N NH1   . ARG A 1 27  ? -11.379 14.437  -7.826  1.000 32.842 0 27  ARG A NH1   1 ? 
ATOM   236  N NH2   . ARG A 1 27  ? -12.098 15.928  -9.418  1.000 36.025 0 27  ARG A NH2   1 ? 
ATOM   237  N N     . ASP A 1 28  ? -7.609  12.730  -13.617 1.000 32.981 0 28  ASP A N     1 ? 
ATOM   238  C CA    . ASP A 1 28  ? -7.324  13.061  -15.041 1.000 33.512 0 28  ASP A CA    1 ? 
ATOM   239  C C     . ASP A 1 28  ? -6.253  12.121  -15.596 1.000 34.302 0 28  ASP A C     1 ? 
ATOM   240  O O     . ASP A 1 28  ? -6.429  11.621  -16.683 1.000 34.995 0 28  ASP A O     1 ? 
ATOM   241  C CB    . ASP A 1 28  ? -6.865  14.510  -15.183 1.000 38.438 0 28  ASP A CB    1 ? 
ATOM   242  C CG    . ASP A 1 28  ? -7.924  15.521  -14.792 1.000 38.515 0 28  ASP A CG    1 ? 
ATOM   243  O OD1   . ASP A 1 28  ? -9.121  15.158  -14.813 1.000 39.399 0 28  ASP A OD1   1 ? 
ATOM   244  O OD2   . ASP A 1 28  ? -7.546  16.671  -14.489 1.000 47.486 0 28  ASP A OD2   1 ? 
ATOM   245  N N     . GLU A 1 29  ? -5.188  11.862  -14.852 1.000 35.403 0 29  GLU A N     1 ? 
ATOM   246  C CA    . GLU A 1 29  ? -4.128  10.920  -15.291 1.000 36.182 0 29  GLU A CA    1 ? 
ATOM   247  C C     . GLU A 1 29  ? -4.741  9.510   -15.456 1.000 33.394 0 29  GLU A C     1 ? 
ATOM   248  O O     . GLU A 1 29  ? -4.488  8.885   -16.486 1.000 33.892 0 29  GLU A O     1 ? 
ATOM   249  C CB    . GLU A 1 29  ? -2.957  10.990  -14.310 1.000 40.526 0 29  GLU A CB    1 ? 
ATOM   250  C CG    . GLU A 1 29  ? -2.322  12.378  -14.241 1.000 48.992 0 29  GLU A CG    1 ? 
ATOM   251  C CD    . GLU A 1 29  ? -1.594  12.715  -12.944 1.000 58.444 0 29  GLU A CD    1 ? 
ATOM   252  O OE1   . GLU A 1 29  ? -0.445  13.216  -13.020 1.000 64.078 0 29  GLU A OE1   1 ? 
ATOM   253  O OE2   . GLU A 1 29  ? -2.176  12.493  -11.858 1.000 58.931 0 29  GLU A OE2   1 ? 
ATOM   254  N N     . ARG A 1 30  ? -5.547  9.061   -14.489 1.000 31.954 0 30  ARG A N     1 ? 
ATOM   255  C CA    . ARG A 1 30  ? -6.323  7.778   -14.524 1.000 31.593 0 30  ARG A CA    1 ? 
ATOM   256  C C     . ARG A 1 30  ? -7.147  7.692   -15.821 1.000 31.926 0 30  ARG A C     1 ? 
ATOM   257  O O     . ARG A 1 30  ? -6.944  6.725   -16.594 1.000 28.799 0 30  ARG A O     1 ? 
ATOM   258  C CB    . ARG A 1 30  ? -7.253  7.693   -13.301 1.000 30.189 0 30  ARG A CB    1 ? 
ATOM   259  C CG    . ARG A 1 30  ? -8.087  6.415   -13.210 1.000 30.084 0 30  ARG A CG    1 ? 
ATOM   260  C CD    . ARG A 1 30  ? -9.224  6.553   -12.226 1.000 30.411 0 30  ARG A CD    1 ? 
ATOM   261  N NE    . ARG A 1 30  ? -10.133 7.635   -12.593 1.000 30.602 0 30  ARG A NE    1 ? 
ATOM   262  C CZ    . ARG A 1 30  ? -10.961 8.265   -11.761 1.000 29.454 0 30  ARG A CZ    1 ? 
ATOM   263  N NH1   . ARG A 1 30  ? -11.022 7.958   -10.470 1.000 29.935 0 30  ARG A NH1   1 ? 
ATOM   264  N NH2   . ARG A 1 30  ? -11.702 9.243   -12.215 1.000 30.852 0 30  ARG A NH2   1 ? 
ATOM   265  N N     . ASP A 1 31  ? -8.034  8.672   -16.040 1.000 34.370 0 31  ASP A N     1 ? 
ATOM   266  C CA    . ASP A 1 31  ? -9.031  8.712   -17.151 1.000 39.393 0 31  ASP A CA    1 ? 
ATOM   267  C C     . ASP A 1 31  ? -8.340  8.694   -18.522 1.000 38.126 0 31  ASP A C     1 ? 
ATOM   268  O O     . ASP A 1 31  ? -8.916  8.125   -19.475 1.000 39.489 0 31  ASP A O     1 ? 
ATOM   269  C CB    . ASP A 1 31  ? -9.946  9.931   -17.017 1.000 39.701 0 31  ASP A CB    1 ? 
ATOM   270  C CG    . ASP A 1 31  ? -10.921 9.808   -15.861 1.000 43.115 0 31  ASP A CG    1 ? 
ATOM   271  O OD1   . ASP A 1 31  ? -10.999 8.693   -15.267 1.000 46.325 0 31  ASP A OD1   1 ? 
ATOM   272  O OD2   . ASP A 1 31  ? -11.617 10.801  -15.575 1.000 44.067 0 31  ASP A OD2   1 ? 
ATOM   273  N N     . ALA A 1 32  ? -7.178  9.324   -18.638 1.000 40.524 0 32  ALA A N     1 ? 
ATOM   274  C CA    . ALA A 1 32  ? -6.395  9.385   -19.889 1.000 41.826 0 32  ALA A CA    1 ? 
ATOM   275  C C     . ALA A 1 32  ? -5.882  7.984   -20.234 1.000 42.098 0 32  ALA A C     1 ? 
ATOM   276  O O     . ALA A 1 32  ? -5.915  7.630   -21.418 1.000 37.455 0 32  ALA A O     1 ? 
ATOM   277  C CB    . ALA A 1 32  ? -5.263  10.374  -19.755 1.000 42.365 0 32  ALA A CB    1 ? 
ATOM   278  N N     . VAL A 1 33  ? -5.399  7.219   -19.249 1.000 36.095 0 33  VAL A N     1 ? 
ATOM   279  C CA    . VAL A 1 33  ? -4.941  5.817   -19.492 1.000 34.592 0 33  VAL A CA    1 ? 
ATOM   280  C C     . VAL A 1 33  ? -6.163  4.980   -19.879 1.000 32.750 0 33  VAL A C     1 ? 
ATOM   281  O O     . VAL A 1 33  ? -6.055  4.193   -20.845 1.000 34.085 0 33  VAL A O     1 ? 
ATOM   282  C CB    . VAL A 1 33  ? -4.189  5.223   -18.290 1.000 36.968 0 33  VAL A CB    1 ? 
ATOM   283  C CG1   . VAL A 1 33  ? -3.888  3.739   -18.500 1.000 38.136 0 33  VAL A CG1   1 ? 
ATOM   284  C CG2   . VAL A 1 33  ? -2.912  6.000   -18.007 1.000 35.833 0 33  VAL A CG2   1 ? 
ATOM   285  N N     . LEU A 1 34  ? -7.297  5.210   -19.210 1.000 33.886 0 34  LEU A N     1 ? 
ATOM   286  C CA    . LEU A 1 34  ? -8.594  4.532   -19.474 1.000 33.735 0 34  LEU A CA    1 ? 
ATOM   287  C C     . LEU A 1 34  ? -9.015  4.780   -20.930 1.000 34.153 0 34  LEU A C     1 ? 
ATOM   288  O O     . LEU A 1 34  ? -9.375  3.784   -21.627 1.000 33.715 0 34  LEU A O     1 ? 
ATOM   289  C CB    . LEU A 1 34  ? -9.649  5.039   -18.477 1.000 34.163 0 34  LEU A CB    1 ? 
ATOM   290  C CG    . LEU A 1 34  ? -9.452  4.583   -17.020 1.000 32.281 0 34  LEU A CG    1 ? 
ATOM   291  C CD1   . LEU A 1 34  ? -10.703 4.838   -16.187 1.000 30.923 0 34  LEU A CD1   1 ? 
ATOM   292  C CD2   . LEU A 1 34  ? -9.065  3.111   -16.945 1.000 32.145 0 34  LEU A CD2   1 ? 
ATOM   293  N N     . THR A 1 35  ? -8.954  6.039   -21.382 1.000 36.004 0 35  THR A N     1 ? 
ATOM   294  C CA    . THR A 1 35  ? -9.299  6.455   -22.775 1.000 35.937 0 35  THR A CA    1 ? 
ATOM   295  C C     . THR A 1 35  ? -8.386  5.716   -23.753 1.000 35.613 0 35  THR A C     1 ? 
ATOM   296  O O     . THR A 1 35  ? -8.905  5.154   -24.730 1.000 37.550 0 35  THR A O     1 ? 
ATOM   297  C CB    . THR A 1 35  ? -9.213  7.977   -22.944 1.000 39.744 0 35  THR A CB    1 ? 
ATOM   298  O OG1   . THR A 1 35  ? -10.096 8.561   -21.986 1.000 35.893 0 35  THR A OG1   1 ? 
ATOM   299  C CG2   . THR A 1 35  ? -9.596  8.434   -24.338 1.000 43.321 0 35  THR A CG2   1 ? 
ATOM   300  N N     . ALA A 1 36  ? -7.085  5.692   -23.467 1.000 36.976 0 36  ALA A N     1 ? 
ATOM   301  C CA    . ALA A 1 36  ? -6.026  5.086   -24.308 1.000 39.108 0 36  ALA A CA    1 ? 
ATOM   302  C C     . ALA A 1 36  ? -6.223  3.562   -24.427 1.000 39.628 0 36  ALA A C     1 ? 
ATOM   303  O O     . ALA A 1 36  ? -5.874  3.014   -25.509 1.000 42.349 0 36  ALA A O     1 ? 
ATOM   304  C CB    . ALA A 1 36  ? -4.671  5.437   -23.754 1.000 40.215 0 36  ALA A CB    1 ? 
ATOM   305  N N     . VAL A 1 37  ? -6.759  2.897   -23.393 1.000 33.279 0 37  VAL A N     1 ? 
ATOM   306  C CA    . VAL A 1 37  ? -7.158  1.451   -23.455 1.000 33.049 0 37  VAL A CA    1 ? 
ATOM   307  C C     . VAL A 1 37  ? -8.354  1.293   -24.412 1.000 34.299 0 37  VAL A C     1 ? 
ATOM   308  O O     . VAL A 1 37  ? -8.305  0.391   -25.266 1.000 32.793 0 37  VAL A O     1 ? 
ATOM   309  C CB    . VAL A 1 37  ? -7.485  0.861   -22.071 1.000 34.420 0 37  VAL A CB    1 ? 
ATOM   310  C CG1   . VAL A 1 37  ? -8.115  -0.529  -22.190 1.000 35.787 0 37  VAL A CG1   1 ? 
ATOM   311  C CG2   . VAL A 1 37  ? -6.259  0.816   -21.163 1.000 32.355 0 37  VAL A CG2   1 ? 
ATOM   312  N N     . ARG A 1 38  ? -9.399  2.108   -24.258 1.000 34.407 0 38  ARG A N     1 ? 
ATOM   313  C CA    . ARG A 1 38  ? -10.616 2.046   -25.114 1.000 37.180 0 38  ARG A CA    1 ? 
ATOM   314  C C     . ARG A 1 38  ? -10.219 2.267   -26.582 1.000 39.225 0 38  ARG A C     1 ? 
ATOM   315  O O     . ARG A 1 38  ? -10.562 1.398   -27.422 1.000 37.552 0 38  ARG A O     1 ? 
ATOM   316  C CB    . ARG A 1 38  ? -11.654 3.080   -24.670 1.000 39.590 0 38  ARG A CB    1 ? 
ATOM   317  C CG    . ARG A 1 38  ? -12.474 2.644   -23.469 1.000 44.735 0 38  ARG A CG    1 ? 
ATOM   318  C CD    . ARG A 1 38  ? -13.693 3.526   -23.254 1.000 48.176 0 38  ARG A CD    1 ? 
ATOM   319  N NE    . ARG A 1 38  ? -13.979 3.650   -21.837 1.000 53.151 0 38  ARG A NE    1 ? 
ATOM   320  C CZ    . ARG A 1 38  ? -13.268 4.385   -20.982 1.000 58.028 0 38  ARG A CZ    1 ? 
ATOM   321  N NH1   . ARG A 1 38  ? -13.609 4.412   -19.704 1.000 61.984 0 38  ARG A NH1   1 ? 
ATOM   322  N NH2   . ARG A 1 38  ? -12.225 5.089   -21.397 1.000 55.714 0 38  ARG A NH2   1 ? 
ATOM   323  N N     . GLU A 1 39  ? -9.506  3.364   -26.872 1.000 38.502 0 39  GLU A N     1 ? 
ATOM   324  C CA    . GLU A 1 39  ? -8.969  3.676   -28.224 1.000 38.694 0 39  GLU A CA    1 ? 
ATOM   325  C C     . GLU A 1 39  ? -8.115  2.509   -28.715 1.000 39.680 0 39  GLU A C     1 ? 
ATOM   326  O O     . GLU A 1 39  ? -8.340  2.051   -29.855 1.000 39.636 0 39  GLU A O     1 ? 
ATOM   327  C CB    . GLU A 1 39  ? -8.086  4.924   -28.234 1.000 44.274 0 39  GLU A CB    1 ? 
ATOM   328  C CG    . GLU A 1 39  ? -8.798  6.202   -27.867 1.000 47.834 0 39  GLU A CG    1 ? 
ATOM   329  C CD    . GLU A 1 39  ? -10.304 6.176   -28.014 1.000 49.484 0 39  GLU A CD    1 ? 
ATOM   330  O OE1   . GLU A 1 39  ? -10.779 6.025   -29.154 1.000 56.084 0 39  GLU A OE1   1 ? 
ATOM   331  O OE2   . GLU A 1 39  ? -10.991 6.298   -26.988 1.000 52.248 0 39  GLU A OE2   1 ? 
ATOM   332  N N     . GLY A 1 40  ? -7.161  2.076   -27.887 1.000 35.646 0 40  GLY A N     1 ? 
ATOM   333  C CA    . GLY A 1 40  ? -6.197  1.004   -28.189 1.000 36.959 0 40  GLY A CA    1 ? 
ATOM   334  C C     . GLY A 1 40  ? -6.875  -0.314  -28.519 1.000 38.555 0 40  GLY A C     1 ? 
ATOM   335  O O     . GLY A 1 40  ? -6.371  -1.011  -29.431 1.000 39.809 0 40  GLY A O     1 ? 
ATOM   336  N N     . LEU A 1 41  ? -7.969  -0.657  -27.822 1.000 35.500 0 41  LEU A N     1 ? 
ATOM   337  C CA    . LEU A 1 41  ? -8.669  -1.972  -27.970 1.000 35.905 0 41  LEU A CA    1 ? 
ATOM   338  C C     . LEU A 1 41  ? -9.368  -2.072  -29.344 1.000 38.039 0 41  LEU A C     1 ? 
ATOM   339  O O     . LEU A 1 41  ? -9.356  -3.188  -29.938 1.000 31.878 0 41  LEU A O     1 ? 
ATOM   340  C CB    . LEU A 1 41  ? -9.670  -2.173  -26.828 1.000 35.516 0 41  LEU A CB    1 ? 
ATOM   341  C CG    . LEU A 1 41  ? -9.103  -2.719  -25.512 1.000 32.364 0 41  LEU A CG    1 ? 
ATOM   342  C CD1   . LEU A 1 41  ? -10.223 -2.926  -24.504 1.000 34.351 0 41  LEU A CD1   1 ? 
ATOM   343  C CD2   . LEU A 1 41  ? -8.322  -4.018  -25.708 1.000 32.884 0 41  LEU A CD2   1 ? 
ATOM   344  N N     . LYS A 1 42  ? -9.940  -0.976  -29.844 1.000 38.973 0 42  LYS A N     1 ? 
ATOM   345  C CA    . LYS A 1 42  ? -10.522 -0.922  -31.217 1.000 44.056 0 42  LYS A CA    1 ? 
ATOM   346  C C     . LYS A 1 42  ? -9.510  -1.496  -32.210 1.000 43.075 0 42  LYS A C     1 ? 
ATOM   347  O O     . LYS A 1 42  ? -9.870  -2.415  -32.960 1.000 53.048 0 42  LYS A O     1 ? 
ATOM   348  C CB    . LYS A 1 42  ? -10.863 0.520   -31.603 1.000 47.412 0 42  LYS A CB    1 ? 
ATOM   349  C CG    . LYS A 1 42  ? -12.022 1.119   -30.829 1.000 49.353 0 42  LYS A CG    1 ? 
ATOM   350  C CD    . LYS A 1 42  ? -12.418 2.494   -31.298 1.000 52.221 0 42  LYS A CD    1 ? 
ATOM   351  C CE    . LYS A 1 42  ? -13.404 3.150   -30.352 1.000 56.708 0 42  LYS A CE    1 ? 
ATOM   352  N NZ    . LYS A 1 42  ? -14.047 4.344   -30.955 1.000 56.848 0 42  LYS A NZ    1 ? 
ATOM   353  N N     . LYS A 1 43  ? -8.278  -0.991  -32.147 1.000 41.501 0 43  LYS A N     1 ? 
ATOM   354  C CA    . LYS A 1 43  ? -7.136  -1.316  -33.040 1.000 42.110 0 43  LYS A CA    1 ? 
ATOM   355  C C     . LYS A 1 43  ? -6.748  -2.793  -32.878 1.000 44.567 0 43  LYS A C     1 ? 
ATOM   356  O O     . LYS A 1 43  ? -6.480  -3.455  -33.906 1.000 44.582 0 43  LYS A O     1 ? 
ATOM   357  C CB    . LYS A 1 43  ? -5.969  -0.392  -32.685 1.000 47.951 0 43  LYS A CB    1 ? 
ATOM   358  C CG    . LYS A 1 43  ? -4.867  -0.268  -33.726 1.000 56.030 0 43  LYS A CG    1 ? 
ATOM   359  C CD    . LYS A 1 43  ? -3.777  0.722   -33.319 1.000 61.092 0 43  LYS A CD    1 ? 
ATOM   360  C CE    . LYS A 1 43  ? -4.195  2.176   -33.456 1.000 64.269 0 43  LYS A CE    1 ? 
ATOM   361  N NZ    . LYS A 1 43  ? -3.997  2.685   -34.836 1.000 64.715 0 43  LYS A NZ    1 ? 
ATOM   362  N N     . VAL A 1 44  ? -6.693  -3.292  -31.639 1.000 37.517 0 44  VAL A N     1 ? 
ATOM   363  C CA    . VAL A 1 44  ? -6.367  -4.722  -31.360 1.000 37.484 0 44  VAL A CA    1 ? 
ATOM   364  C C     . VAL A 1 44  ? -7.462  -5.611  -31.969 1.000 36.262 0 44  VAL A C     1 ? 
ATOM   365  O O     . VAL A 1 44  ? -7.090  -6.656  -32.547 1.000 37.657 0 44  VAL A O     1 ? 
ATOM   366  C CB    . VAL A 1 44  ? -6.184  -4.994  -29.856 1.000 37.781 0 44  VAL A CB    1 ? 
ATOM   367  C CG1   . VAL A 1 44  ? -6.084  -6.485  -29.575 1.000 38.565 0 44  VAL A CG1   1 ? 
ATOM   368  C CG2   . VAL A 1 44  ? -4.976  -4.258  -29.286 1.000 37.977 0 44  VAL A CG2   1 ? 
ATOM   369  N N     . PHE A 1 45  ? -8.747  -5.211  -31.866 1.000 32.529 0 45  PHE A N     1 ? 
ATOM   370  C CA    . PHE A 1 45  ? -9.928  -6.039  -32.248 1.000 33.692 0 45  PHE A CA    1 ? 
ATOM   371  C C     . PHE A 1 45  ? -10.332 -5.812  -33.714 1.000 33.050 0 45  PHE A C     1 ? 
ATOM   372  O O     . PHE A 1 45  ? -11.169 -6.591  -34.215 1.000 33.580 0 45  PHE A O     1 ? 
ATOM   373  C CB    . PHE A 1 45  ? -11.089 -5.844  -31.271 1.000 32.253 0 45  PHE A CB    1 ? 
ATOM   374  C CG    . PHE A 1 45  ? -10.957 -6.710  -30.043 1.000 35.173 0 45  PHE A CG    1 ? 
ATOM   375  C CD1   . PHE A 1 45  ? -10.040 -6.383  -29.052 1.000 35.668 0 45  PHE A CD1   1 ? 
ATOM   376  C CD2   . PHE A 1 45  ? -11.652 -7.905  -29.929 1.000 33.894 0 45  PHE A CD2   1 ? 
ATOM   377  C CE1   . PHE A 1 45  ? -9.852  -7.209  -27.956 1.000 32.771 0 45  PHE A CE1   1 ? 
ATOM   378  C CE2   . PHE A 1 45  ? -11.469 -8.724  -28.822 1.000 36.644 0 45  PHE A CE2   1 ? 
ATOM   379  C CZ    . PHE A 1 45  ? -10.585 -8.363  -27.828 1.000 35.856 0 45  PHE A CZ    1 ? 
ATOM   380  N N     . ALA A 1 46  ? -9.705  -4.864  -34.406 1.000 36.631 0 46  ALA A N     1 ? 
ATOM   381  C CA    . ALA A 1 46  ? -9.844  -4.681  -35.873 1.000 37.584 0 46  ALA A CA    1 ? 
ATOM   382  C C     . ALA A 1 46  ? -9.337  -5.937  -36.599 1.000 37.616 0 46  ALA A C     1 ? 
ATOM   383  O O     . ALA A 1 46  ? -9.864  -6.241  -37.684 1.000 36.196 0 46  ALA A O     1 ? 
ATOM   384  C CB    . ALA A 1 46  ? -9.106  -3.451  -36.316 1.000 40.070 0 46  ALA A CB    1 ? 
ATOM   385  N N     . ASP A 1 47  ? -8.348  -6.640  -36.022 1.000 36.012 0 47  ASP A N     1 ? 
ATOM   386  C CA    . ASP A 1 47  ? -7.736  -7.869  -36.603 1.000 37.356 0 47  ASP A CA    1 ? 
ATOM   387  C C     . ASP A 1 47  ? -8.556  -9.105  -36.223 1.000 35.387 0 47  ASP A C     1 ? 
ATOM   388  O O     . ASP A 1 47  ? -8.184  -10.210 -36.677 1.000 31.978 0 47  ASP A O     1 ? 
ATOM   389  C CB    . ASP A 1 47  ? -6.305  -8.069  -36.100 1.000 43.850 0 47  ASP A CB    1 ? 
ATOM   390  C CG    . ASP A 1 47  ? -5.260  -7.352  -36.925 1.000 49.214 0 47  ASP A CG    1 ? 
ATOM   391  O OD1   . ASP A 1 47  ? -5.411  -7.311  -38.173 1.000 54.934 0 47  ASP A OD1   1 ? 
ATOM   392  O OD2   . ASP A 1 47  ? -4.306  -6.846  -36.314 1.000 61.162 0 47  ASP A OD2   1 ? 
ATOM   393  N N     . ARG A 1 48  ? -9.577  -8.924  -35.374 1.000 32.970 0 48  ARG A N     1 ? 
ATOM   394  C CA    . ARG A 1 48  ? -10.409 -10.005 -34.775 1.000 36.864 0 48  ARG A CA    1 ? 
ATOM   395  C C     . ARG A 1 48  ? -11.710 -10.157 -35.564 1.000 31.167 0 48  ARG A C     1 ? 
ATOM   396  O O     . ARG A 1 48  ? -12.221 -11.263 -35.577 1.000 28.354 0 48  ARG A O     1 ? 
ATOM   397  C CB    . ARG A 1 48  ? -10.766 -9.664  -33.322 1.000 40.178 0 48  ARG A CB    1 ? 
ATOM   398  C CG    . ARG A 1 48  ? -11.304 -10.838 -32.515 1.000 45.508 0 48  ARG A CG    1 ? 
ATOM   399  C CD    . ARG A 1 48  ? -10.189 -11.665 -31.906 1.000 50.823 0 48  ARG A CD    1 ? 
ATOM   400  N NE    . ARG A 1 48  ? -10.643 -12.476 -30.785 1.000 54.868 0 48  ARG A NE    1 ? 
ATOM   401  C CZ    . ARG A 1 48  ? -9.902  -12.785 -29.724 1.000 56.089 0 48  ARG A CZ    1 ? 
ATOM   402  N NH1   . ARG A 1 48  ? -10.417 -13.533 -28.764 1.000 63.182 0 48  ARG A NH1   1 ? 
ATOM   403  N NH2   . ARG A 1 48  ? -8.658  -12.347 -29.617 1.000 54.644 0 48  ARG A NH2   1 ? 
ATOM   404  N N     . GLY A 1 49  ? -12.272 -9.036  -36.034 1.000 26.833 0 49  GLY A N     1 ? 
ATOM   405  C CA    . GLY A 1 49  ? -13.466 -8.980  -36.892 1.000 31.431 0 49  GLY A CA    1 ? 
ATOM   406  C C     . GLY A 1 49  ? -14.741 -8.719  -36.101 1.000 33.833 0 49  GLY A C     1 ? 
ATOM   407  O O     . GLY A 1 49  ? -15.826 -9.111  -36.566 1.000 30.081 0 49  GLY A O     1 ? 
ATOM   408  N N     . GLU A 1 50  ? -14.623 -8.113  -34.916 1.000 33.389 0 50  GLU A N     1 ? 
ATOM   409  C CA    . GLU A 1 50  ? -15.768 -7.802  -34.034 1.000 34.421 0 50  GLU A CA    1 ? 
ATOM   410  C C     . GLU A 1 50  ? -15.347 -6.658  -33.121 1.000 33.942 0 50  GLU A C     1 ? 
ATOM   411  O O     . GLU A 1 50  ? -14.122 -6.464  -32.961 1.000 34.545 0 50  GLU A O     1 ? 
ATOM   412  C CB    . GLU A 1 50  ? -16.137 -9.029  -33.211 1.000 38.114 0 50  GLU A CB    1 ? 
ATOM   413  C CG    . GLU A 1 50  ? -14.923 -9.640  -32.550 1.000 43.027 0 50  GLU A CG    1 ? 
ATOM   414  C CD    . GLU A 1 50  ? -15.184 -10.622 -31.426 1.000 46.136 0 50  GLU A CD    1 ? 
ATOM   415  O OE1   . GLU A 1 50  ? -14.205 -11.272 -30.995 1.000 48.150 0 50  GLU A OE1   1 ? 
ATOM   416  O OE2   . GLU A 1 50  ? -16.350 -10.739 -30.989 1.000 46.656 0 50  GLU A OE2   1 ? 
ATOM   417  N N     . ALA A 1 51  ? -16.316 -5.950  -32.558 1.000 33.034 0 51  ALA A N     1 ? 
ATOM   418  C CA    . ALA A 1 51  ? -16.114 -4.843  -31.595 1.000 34.721 0 51  ALA A CA    1 ? 
ATOM   419  C C     . ALA A 1 51  ? -15.226 -5.323  -30.434 1.000 35.616 0 51  ALA A C     1 ? 
ATOM   420  O O     . ALA A 1 51  ? -15.351 -6.507  -30.018 1.000 27.792 0 51  ALA A O     1 ? 
ATOM   421  C CB    . ALA A 1 51  ? -17.454 -4.358  -31.087 1.000 36.316 0 51  ALA A CB    1 ? 
ATOM   422  N N     . ALA A 1 52  ? -14.342 -4.450  -29.952 1.000 36.654 0 52  ALA A N     1 ? 
ATOM   423  C CA    . ALA A 1 52  ? -13.602 -4.624  -28.683 1.000 37.999 0 52  ALA A CA    1 ? 
ATOM   424  C C     . ALA A 1 52  ? -14.605 -4.860  -27.557 1.000 35.358 0 52  ALA A C     1 ? 
ATOM   425  O O     . ALA A 1 52  ? -15.732 -4.371  -27.593 1.000 28.788 0 52  ALA A O     1 ? 
ATOM   426  C CB    . ALA A 1 52  ? -12.734 -3.421  -28.411 1.000 37.477 0 52  ALA A CB    1 ? 
ATOM   427  N N     . PRO A 1 53  ? -14.243 -5.662  -26.538 1.000 33.875 0 53  PRO A N     1 ? 
ATOM   428  C CA    . PRO A 1 53  ? -15.077 -5.789  -25.352 1.000 33.473 0 53  PRO A CA    1 ? 
ATOM   429  C C     . PRO A 1 53  ? -15.166 -4.463  -24.576 1.000 32.656 0 53  PRO A C     1 ? 
ATOM   430  O O     . PRO A 1 53  ? -14.196 -3.689  -24.542 1.000 33.794 0 53  PRO A O     1 ? 
ATOM   431  C CB    . PRO A 1 53  ? -14.370 -6.892  -24.544 1.000 33.968 0 53  PRO A CB    1 ? 
ATOM   432  C CG    . PRO A 1 53  ? -12.920 -6.756  -24.958 1.000 35.506 0 53  PRO A CG    1 ? 
ATOM   433  C CD    . PRO A 1 53  ? -12.983 -6.416  -26.433 1.000 36.235 0 53  PRO A CD    1 ? 
ATOM   434  N N     . THR A 1 54  ? -16.362 -4.189  -24.075 1.000 29.304 0 54  THR A N     1 ? 
ATOM   435  C CA    . THR A 1 54  ? -16.676 -3.188  -23.024 1.000 31.571 0 54  THR A CA    1 ? 
ATOM   436  C C     . THR A 1 54  ? -15.891 -3.510  -21.737 1.000 28.177 0 54  THR A C     1 ? 
ATOM   437  O O     . THR A 1 54  ? -15.726 -4.697  -21.424 1.000 25.845 0 54  THR A O     1 ? 
ATOM   438  C CB    . THR A 1 54  ? -18.197 -3.208  -22.828 1.000 30.643 0 54  THR A CB    1 ? 
ATOM   439  O OG1   . THR A 1 54  ? -18.726 -2.535  -23.976 1.000 41.754 0 54  THR A OG1   1 ? 
ATOM   440  C CG2   . THR A 1 54  ? -18.674 -2.548  -21.566 1.000 39.334 0 54  THR A CG2   1 ? 
ATOM   441  N N     . PHE A 1 55  ? -15.507 -2.509  -20.944 1.000 30.315 0 55  PHE A N     1 ? 
ATOM   442  C CA    . PHE A 1 55  ? -15.012 -2.756  -19.555 1.000 26.789 0 55  PHE A CA    1 ? 
ATOM   443  C C     . PHE A 1 55  ? -15.607 -1.731  -18.599 1.000 27.267 0 55  PHE A C     1 ? 
ATOM   444  O O     . PHE A 1 55  ? -15.995 -0.635  -19.059 1.000 24.586 0 55  PHE A O     1 ? 
ATOM   445  C CB    . PHE A 1 55  ? -13.480 -2.774  -19.481 1.000 25.707 0 55  PHE A CB    1 ? 
ATOM   446  C CG    . PHE A 1 55  ? -12.807 -1.469  -19.816 1.000 26.916 0 55  PHE A CG    1 ? 
ATOM   447  C CD1   . PHE A 1 55  ? -12.637 -0.491  -18.847 1.000 24.712 0 55  PHE A CD1   1 ? 
ATOM   448  C CD2   . PHE A 1 55  ? -12.375 -1.210  -21.107 1.000 28.952 0 55  PHE A CD2   1 ? 
ATOM   449  C CE1   . PHE A 1 55  ? -12.060 0.721   -19.166 1.000 28.022 0 55  PHE A CE1   1 ? 
ATOM   450  C CE2   . PHE A 1 55  ? -11.791 0.006   -21.421 1.000 29.526 0 55  PHE A CE2   1 ? 
ATOM   451  C CZ    . PHE A 1 55  ? -11.614 0.955   -20.442 1.000 29.918 0 55  PHE A CZ    1 ? 
ATOM   452  N N     . THR A 1 56  ? -15.685 -2.099  -17.311 1.000 26.685 0 56  THR A N     1 ? 
ATOM   453  C CA    . THR A 1 56  ? -16.114 -1.197  -16.199 1.000 29.056 0 56  THR A CA    1 ? 
ATOM   454  C C     . THR A 1 56  ? -14.905 -0.927  -15.319 1.000 25.742 0 56  THR A C     1 ? 
ATOM   455  O O     . THR A 1 56  ? -14.329 -1.867  -14.781 1.000 24.390 0 56  THR A O     1 ? 
ATOM   456  C CB    . THR A 1 56  ? -17.264 -1.793  -15.389 1.000 29.986 0 56  THR A CB    1 ? 
ATOM   457  O OG1   . THR A 1 56  ? -18.305 -2.117  -16.307 1.000 37.826 0 56  THR A OG1   1 ? 
ATOM   458  C CG2   . THR A 1 56  ? -17.799 -0.840  -14.345 1.000 30.771 0 56  THR A CG2   1 ? 
ATOM   459  N N     . PRO A 1 57  ? -14.436 0.336   -15.210 1.000 24.857 0 57  PRO A N     1 ? 
ATOM   460  C CA    . PRO A 1 57  ? -13.281 0.641   -14.374 1.000 24.383 0 57  PRO A CA    1 ? 
ATOM   461  C C     . PRO A 1 57  ? -13.701 0.899   -12.918 1.000 23.496 0 57  PRO A C     1 ? 
ATOM   462  O O     . PRO A 1 57  ? -14.862 1.131   -12.648 1.000 21.632 0 57  PRO A O     1 ? 
ATOM   463  C CB    . PRO A 1 57  ? -12.699 1.886   -15.074 1.000 27.066 0 57  PRO A CB    1 ? 
ATOM   464  C CG    . PRO A 1 57  ? -13.943 2.625   -15.574 1.000 26.741 0 57  PRO A CG    1 ? 
ATOM   465  C CD    . PRO A 1 57  ? -14.931 1.525   -15.936 1.000 26.962 0 57  PRO A CD    1 ? 
ATOM   466  N N     . PHE A 1 58  ? -12.767 0.745   -11.984 1.000 22.617 0 58  PHE A N     1 ? 
ATOM   467  C CA    . PHE A 1 58  ? -12.999 1.073   -10.563 1.000 21.486 0 58  PHE A CA    1 ? 
ATOM   468  C C     . PHE A 1 58  ? -11.652 1.386   -9.926  1.000 20.495 0 58  PHE A C     1 ? 
ATOM   469  O O     . PHE A 1 58  ? -10.619 0.857   -10.351 1.000 19.803 0 58  PHE A O     1 ? 
ATOM   470  C CB    . PHE A 1 58  ? -13.777 -0.032  -9.838  1.000 20.780 0 58  PHE A CB    1 ? 
ATOM   471  C CG    . PHE A 1 58  ? -13.036 -1.344  -9.687  1.000 19.717 0 58  PHE A CG    1 ? 
ATOM   472  C CD1   . PHE A 1 58  ? -13.035 -2.283  -10.713 1.000 17.646 0 58  PHE A CD1   1 ? 
ATOM   473  C CD2   . PHE A 1 58  ? -12.324 -1.633  -8.533  1.000 17.951 0 58  PHE A CD2   1 ? 
ATOM   474  C CE1   . PHE A 1 58  ? -12.344 -3.474  -10.580 1.000 16.930 0 58  PHE A CE1   1 ? 
ATOM   475  C CE2   . PHE A 1 58  ? -11.616 -2.825  -8.412  1.000 16.650 0 58  PHE A CE2   1 ? 
ATOM   476  C CZ    . PHE A 1 58  ? -11.624 -3.735  -9.431  1.000 15.479 0 58  PHE A CZ    1 ? 
ATOM   477  N N     . ASN A 1 59  ? -11.667 2.321   -8.989  1.000 20.543 0 59  ASN A N     1 ? 
ATOM   478  C CA    . ASN A 1 59  ? -10.457 2.744   -8.253  1.000 20.081 0 59  ASN A CA    1 ? 
ATOM   479  C C     . ASN A 1 59  ? -9.953  1.584   -7.407  1.000 18.890 0 59  ASN A C     1 ? 
ATOM   480  O O     . ASN A 1 59  ? -10.796 0.889   -6.773  1.000 18.259 0 59  ASN A O     1 ? 
ATOM   481  C CB    . ASN A 1 59  ? -10.746 3.949   -7.355  1.000 20.424 0 59  ASN A CB    1 ? 
ATOM   482  C CG    . ASN A 1 59  ? -11.083 5.191   -8.151  1.000 23.734 0 59  ASN A CG    1 ? 
ATOM   483  O OD1   . ASN A 1 59  ? -10.633 5.351   -9.291  1.000 22.717 0 59  ASN A OD1   1 ? 
ATOM   484  N ND2   . ASN A 1 59  ? -11.850 6.078   -7.545  1.000 22.655 0 59  ASN A ND2   1 ? 
ATOM   485  N N     . GLN A 1 60  ? -8.640  1.434   -7.327  1.000 18.003 0 60  GLN A N     1 ? 
ATOM   486  C CA    . GLN A 1 60  ? -7.976  0.460   -6.420  1.000 19.618 0 60  GLN A CA    1 ? 
ATOM   487  C C     . GLN A 1 60  ? -6.869  1.158   -5.654  1.000 19.375 0 60  GLN A C     1 ? 
ATOM   488  O O     . GLN A 1 60  ? -6.523  2.301   -6.035  1.000 18.323 0 60  GLN A O     1 ? 
ATOM   489  C CB    . GLN A 1 60  ? -7.339  -0.691  -7.193  1.000 21.487 0 60  GLN A CB    1 ? 
ATOM   490  C CG    . GLN A 1 60  ? -8.364  -1.587  -7.842  1.000 22.735 0 60  GLN A CG    1 ? 
ATOM   491  C CD    . GLN A 1 60  ? -7.771  -2.908  -8.252  1.000 23.398 0 60  GLN A CD    1 ? 
ATOM   492  O OE1   . GLN A 1 60  ? -8.210  -3.515  -9.202  1.000 23.839 0 60  GLN A OE1   1 ? 
ATOM   493  N NE2   . GLN A 1 60  ? -6.799  -3.384  -7.498  1.000 28.027 0 60  GLN A NE2   1 ? 
ATOM   494  N N     . GLY A 1 61  ? -6.344  0.480   -4.628  1.000 17.365 0 61  GLY A N     1 ? 
ATOM   495  C CA    . GLY A 1 61  ? -5.081  0.831   -3.964  1.000 18.140 0 61  GLY A CA    1 ? 
ATOM   496  C C     . GLY A 1 61  ? -5.195  2.073   -3.114  1.000 15.337 0 61  GLY A C     1 ? 
ATOM   497  O O     . GLY A 1 61  ? -6.327  2.478   -2.774  1.000 13.667 0 61  GLY A O     1 ? 
ATOM   498  N N     . SER A 1 62  ? -4.054  2.674   -2.789  1.000 15.105 0 62  SER A N     1 ? 
ATOM   499  C CA    . SER A 1 62  ? -3.933  3.694   -1.712  1.000 16.533 0 62  SER A CA    1 ? 
ATOM   500  C C     . SER A 1 62  ? -4.774  4.918   -2.057  1.000 16.313 0 62  SER A C     1 ? 
ATOM   501  O O     . SER A 1 62  ? -5.321  5.523   -1.139  1.000 13.754 0 62  SER A O     1 ? 
ATOM   502  C CB    . SER A 1 62  ? -2.498  4.075   -1.434  1.000 17.195 0 62  SER A CB    1 ? 
ATOM   503  O OG    . SER A 1 62  ? -1.860  4.508   -2.608  1.000 22.730 0 62  SER A OG    1 ? 
ATOM   504  N N     . TYR A 1 63  ? -4.875  5.276   -3.337  1.000 17.083 0 63  TYR A N     1 ? 
ATOM   505  C CA    . TYR A 1 63  ? -5.590  6.511   -3.734  1.000 17.721 0 63  TYR A CA    1 ? 
ATOM   506  C C     . TYR A 1 63  ? -7.105  6.290   -3.652  1.000 16.748 0 63  TYR A C     1 ? 
ATOM   507  O O     . TYR A 1 63  ? -7.838  7.309   -3.545  1.000 19.704 0 63  TYR A O     1 ? 
ATOM   508  C CB    . TYR A 1 63  ? -5.100  7.017   -5.101  1.000 21.467 0 63  TYR A CB    1 ? 
ATOM   509  C CG    . TYR A 1 63  ? -3.602  7.176   -5.289  1.000 23.726 0 63  TYR A CG    1 ? 
ATOM   510  C CD1   . TYR A 1 63  ? -2.699  7.240   -4.236  1.000 28.149 0 63  TYR A CD1   1 ? 
ATOM   511  C CD2   . TYR A 1 63  ? -3.080  7.266   -6.571  1.000 29.187 0 63  TYR A CD2   1 ? 
ATOM   512  C CE1   . TYR A 1 63  ? -1.331  7.394   -4.456  1.000 27.205 0 63  TYR A CE1   1 ? 
ATOM   513  C CE2   . TYR A 1 63  ? -1.726  7.460   -6.811  1.000 28.858 0 63  TYR A CE2   1 ? 
ATOM   514  C CZ    . TYR A 1 63  ? -0.840  7.506   -5.755  1.000 31.637 0 63  TYR A CZ    1 ? 
ATOM   515  O OH    . TYR A 1 63  ? 0.498   7.676   -6.044  1.000 28.312 0 63  TYR A OH    1 ? 
ATOM   516  N N     . ALA A 1 64  ? -7.580  5.036   -3.630  1.000 14.912 0 64  ALA A N     1 ? 
ATOM   517  C CA    . ALA A 1 64  ? -9.002  4.674   -3.357  1.000 16.662 0 64  ALA A CA    1 ? 
ATOM   518  C C     . ALA A 1 64  ? -9.272  4.585   -1.852  1.000 18.677 0 64  ALA A C     1 ? 
ATOM   519  O O     . ALA A 1 64  ? -10.402 4.825   -1.433  1.000 16.735 0 64  ALA A O     1 ? 
ATOM   520  C CB    . ALA A 1 64  ? -9.329  3.357   -4.015  1.000 18.366 0 64  ALA A CB    1 ? 
ATOM   521  N N     . MET A 1 65  ? -8.257  4.252   -1.062  1.000 17.902 0 65  MET A N     1 ? 
ATOM   522  C CA    . MET A 1 65  ? -8.415  3.981   0.397   1.000 16.745 0 65  MET A CA    1 ? 
ATOM   523  C C     . MET A 1 65  ? -8.008  5.168   1.259   1.000 14.772 0 65  MET A C     1 ? 
ATOM   524  O O     . MET A 1 65  ? -8.074  5.036   2.508   1.000 15.698 0 65  MET A O     1 ? 
ATOM   525  C CB    . MET A 1 65  ? -7.583  2.762   0.783   1.000 16.319 0 65  MET A CB    1 ? 
ATOM   526  C CG    . MET A 1 65  ? -8.008  1.550   0.055   1.000 18.359 0 65  MET A CG    1 ? 
ATOM   527  S SD    . MET A 1 65  ? -7.306  0.022   0.712   1.000 18.653 0 65  MET A SD    1 ? 
ATOM   528  C CE    . MET A 1 65  ? -5.610  0.116   0.146   1.000 23.759 0 65  MET A CE    1 ? 
ATOM   529  N N     . ASN A 1 66  ? -7.542  6.261   0.650   1.000 15.300 0 66  ASN A N     1 ? 
ATOM   530  C CA    . ASN A 1 66  ? -7.165  7.510   1.346   1.000 14.472 0 66  ASN A CA    1 ? 
ATOM   531  C C     . ASN A 1 66  ? -5.992  7.215   2.283   1.000 12.908 0 66  ASN A C     1 ? 
ATOM   532  O O     . ASN A 1 66  ? -5.995  7.709   3.410   1.000 11.285 0 66  ASN A O     1 ? 
ATOM   533  C CB    . ASN A 1 66  ? -8.345  8.091   2.119   1.000 15.535 0 66  ASN A CB    1 ? 
ATOM   534  C CG    . ASN A 1 66  ? -8.156  9.533   2.508   1.000 17.520 0 66  ASN A CG    1 ? 
ATOM   535  O OD1   . ASN A 1 66  ? -7.286  10.221  1.967   1.000 17.585 0 66  ASN A OD1   1 ? 
ATOM   536  N ND2   . ASN A 1 66  ? -9.010  10.011  3.409   1.000 16.394 0 66  ASN A ND2   1 ? 
ATOM   537  N N     . THR A 1 67  ? -5.048  6.415   1.816   1.000 13.365 0 67  THR A N     1 ? 
ATOM   538  C CA    . THR A 1 67  ? -3.777  6.078   2.520   1.000 14.068 0 67  THR A CA    1 ? 
ATOM   539  C C     . THR A 1 67  ? -2.568  6.471   1.658   1.000 14.032 0 67  THR A C     1 ? 
ATOM   540  O O     . THR A 1 67  ? -1.476  5.987   1.956   1.000 14.800 0 67  THR A O     1 ? 
ATOM   541  C CB    . THR A 1 67  ? -3.732  4.593   2.865   1.000 14.423 0 67  THR A CB    1 ? 
ATOM   542  O OG1   . THR A 1 67  ? -3.844  3.904   1.614   1.000 16.016 0 67  THR A OG1   1 ? 
ATOM   543  C CG2   . THR A 1 67  ? -4.831  4.212   3.825   1.000 17.202 0 67  THR A CG2   1 ? 
ATOM   544  N N     . GLY A 1 68  ? -2.758  7.346   0.663   1.000 14.523 0 68  GLY A N     1 ? 
ATOM   545  C CA    . GLY A 1 68  ? -1.715  7.758   -0.295  1.000 15.637 0 68  GLY A CA    1 ? 
ATOM   546  C C     . GLY A 1 68  ? -0.660  8.660   0.325   1.000 13.840 0 68  GLY A C     1 ? 
ATOM   547  O O     . GLY A 1 68  ? -1.026  9.523   1.116   1.000 13.714 0 68  GLY A O     1 ? 
ATOM   548  N N     . VAL A 1 69  ? 0.596   8.487   -0.079  1.000 13.724 0 69  VAL A N     1 ? 
ATOM   549  C CA    . VAL A 1 69  ? 1.735   9.339   0.331   1.000 15.545 0 69  VAL A CA    1 ? 
ATOM   550  C C     . VAL A 1 69  ? 2.410   9.902   -0.903  1.000 16.362 0 69  VAL A C     1 ? 
ATOM   551  O O     . VAL A 1 69  ? 2.352   9.273   -1.967  1.000 14.702 0 69  VAL A O     1 ? 
ATOM   552  C CB    . VAL A 1 69  ? 2.735   8.593   1.224   1.000 15.112 0 69  VAL A CB    1 ? 
ATOM   553  C CG1   . VAL A 1 69  ? 2.067   8.255   2.544   1.000 16.394 0 69  VAL A CG1   1 ? 
ATOM   554  C CG2   . VAL A 1 69  ? 3.278   7.348   0.552   1.000 16.777 0 69  VAL A CG2   1 ? 
ATOM   555  N N     . LYS A 1 70  ? 2.935   11.108  -0.777  1.000 16.496 0 70  LYS A N     1 ? 
ATOM   556  C CA    . LYS A 1 70  ? 3.734   11.722  -1.850  1.000 17.107 0 70  LYS A CA    1 ? 
ATOM   557  C C     . LYS A 1 70  ? 4.983   10.883  -1.960  1.000 17.531 0 70  LYS A C     1 ? 
ATOM   558  O O     . LYS A 1 70  ? 5.543   10.467  -0.951  1.000 16.525 0 70  LYS A O     1 ? 
ATOM   559  C CB    . LYS A 1 70  ? 4.040   13.185  -1.524  1.000 17.724 0 70  LYS A CB    1 ? 
ATOM   560  C CG    . LYS A 1 70  ? 2.821   14.075  -1.511  1.000 20.020 0 70  LYS A CG    1 ? 
ATOM   561  C CD    . LYS A 1 70  ? 3.132   15.504  -1.251  1.000 20.695 0 70  LYS A CD    1 ? 
ATOM   562  C CE    . LYS A 1 70  ? 2.031   16.392  -1.733  1.000 24.578 0 70  LYS A CE    1 ? 
ATOM   563  N NZ    . LYS A 1 70  ? 2.074   17.668  -1.009  1.000 26.560 0 70  LYS A NZ    1 ? 
ATOM   564  N N     . PRO A 1 71  ? 5.472   10.603  -3.170  1.000 19.414 0 71  PRO A N     1 ? 
ATOM   565  C CA    . PRO A 1 71  ? 6.744   9.912   -3.282  1.000 22.833 0 71  PRO A CA    1 ? 
ATOM   566  C C     . PRO A 1 71  ? 7.873   10.842  -2.797  1.000 23.765 0 71  PRO A C     1 ? 
ATOM   567  O O     . PRO A 1 71  ? 7.675   12.057  -2.727  1.000 22.934 0 71  PRO A O     1 ? 
ATOM   568  C CB    . PRO A 1 71  ? 6.826   9.578   -4.771  1.000 24.977 0 71  PRO A CB    1 ? 
ATOM   569  C CG    . PRO A 1 71  ? 5.977   10.662  -5.452  1.000 25.038 0 71  PRO A CG    1 ? 
ATOM   570  C CD    . PRO A 1 71  ? 4.903   11.037  -4.454  1.000 21.665 0 71  PRO A CD    1 ? 
ATOM   571  N N     . LEU A 1 72  ? 9.022   10.287  -2.457  1.000 24.527 0 72  LEU A N     1 ? 
ATOM   572  C CA    . LEU A 1 72  ? 10.245  11.106  -2.247  1.000 26.422 0 72  LEU A CA    1 ? 
ATOM   573  C C     . LEU A 1 72  ? 10.646  11.779  -3.571  1.000 30.427 0 72  LEU A C     1 ? 
ATOM   574  O O     . LEU A 1 72  ? 10.179  11.361  -4.627  1.000 25.196 0 72  LEU A O     1 ? 
ATOM   575  C CB    . LEU A 1 72  ? 11.348  10.196  -1.725  1.000 26.847 0 72  LEU A CB    1 ? 
ATOM   576  C CG    . LEU A 1 72  ? 11.112  9.603   -0.340  1.000 27.361 0 72  LEU A CG    1 ? 
ATOM   577  C CD1   . LEU A 1 72  ? 12.271  8.703   0.015   1.000 30.521 0 72  LEU A CD1   1 ? 
ATOM   578  C CD2   . LEU A 1 72  ? 10.924  10.686  0.715   1.000 26.390 0 72  LEU A CD2   1 ? 
ATOM   579  N N     . GLU A 1 73  ? 11.509  12.793  -3.525  1.000 40.550 0 73  GLU A N     1 ? 
ATOM   580  C CA    . GLU A 1 73  ? 11.919  13.544  -4.749  1.000 47.060 0 73  GLU A CA    1 ? 
ATOM   581  C C     . GLU A 1 73  ? 12.438  12.546  -5.792  1.000 43.202 0 73  GLU A C     1 ? 
ATOM   582  O O     . GLU A 1 73  ? 13.297  11.722  -5.443  1.000 41.534 0 73  GLU A O     1 ? 
ATOM   583  C CB    . GLU A 1 73  ? 12.955  14.618  -4.411  1.000 53.704 0 73  GLU A CB    1 ? 
ATOM   584  C CG    . GLU A 1 73  ? 12.983  15.759  -5.416  1.000 62.196 0 73  GLU A CG    1 ? 
ATOM   585  C CD    . GLU A 1 73  ? 13.719  16.999  -4.935  1.000 69.162 0 73  GLU A CD    1 ? 
ATOM   586  O OE1   . GLU A 1 73  ? 14.619  17.470  -5.661  1.000 81.591 0 73  GLU A OE1   1 ? 
ATOM   587  O OE2   . GLU A 1 73  ? 13.391  17.492  -3.835  1.000 72.821 0 73  GLU A OE2   1 ? 
ATOM   588  N N     . GLY A 1 74  ? 11.868  12.566  -7.003  1.000 47.429 0 74  GLY A N     1 ? 
ATOM   589  C CA    . GLY A 1 74  ? 12.277  11.696  -8.129  1.000 47.436 0 74  GLY A CA    1 ? 
ATOM   590  C C     . GLY A 1 74  ? 11.698  10.282  -8.045  1.000 53.587 0 74  GLY A C     1 ? 
ATOM   591  O O     . GLY A 1 74  ? 12.109  9.433   -8.863  1.000 52.178 0 74  GLY A O     1 ? 
ATOM   592  N N     . GLY A 1 75  ? 10.810  10.017  -7.076  1.000 52.108 0 75  GLY A N     1 ? 
ATOM   593  C CA    . GLY A 1 75  ? 9.944   8.821   -7.041  1.000 46.523 0 75  GLY A CA    1 ? 
ATOM   594  C C     . GLY A 1 75  ? 8.714   9.028   -7.907  1.000 45.240 0 75  GLY A C     1 ? 
ATOM   595  O O     . GLY A 1 75  ? 8.534   10.166  -8.398  1.000 42.028 0 75  GLY A O     1 ? 
ATOM   596  N N     . GLU A 1 76  ? 7.890   7.982   -8.077  1.000 42.868 0 76  GLU A N     1 ? 
ATOM   597  C CA    . GLU A 1 76  ? 6.733   7.950   -9.008  1.000 43.571 0 76  GLU A CA    1 ? 
ATOM   598  C C     . GLU A 1 76  ? 5.424   7.781   -8.227  1.000 41.759 0 76  GLU A C     1 ? 
ATOM   599  O O     . GLU A 1 76  ? 5.424   6.977   -7.287  1.000 39.403 0 76  GLU A O     1 ? 
ATOM   600  C CB    . GLU A 1 76  ? 6.881   6.770   -9.977  1.000 50.514 0 76  GLU A CB    1 ? 
ATOM   601  C CG    . GLU A 1 76  ? 7.891   6.999   -11.088 1.000 52.670 0 76  GLU A CG    1 ? 
ATOM   602  C CD    . GLU A 1 76  ? 8.021   5.824   -12.046 1.000 57.778 0 76  GLU A CD    1 ? 
ATOM   603  O OE1   . GLU A 1 76  ? 9.161   5.391   -12.279 1.000 57.856 0 76  GLU A OE1   1 ? 
ATOM   604  O OE2   . GLU A 1 76  ? 6.972   5.339   -12.553 1.000 57.570 0 76  GLU A OE2   1 ? 
ATOM   605  N N     . TYR A 1 77  ? 4.341   8.436   -8.675  1.000 37.454 0 77  TYR A N     1 ? 
ATOM   606  C CA    . TYR A 1 77  ? 2.937   8.114   -8.298  1.000 40.822 0 77  TYR A CA    1 ? 
ATOM   607  C C     . TYR A 1 77  ? 2.608   6.703   -8.799  1.000 35.747 0 77  TYR A C     1 ? 
ATOM   608  O O     . TYR A 1 77  ? 3.059   6.312   -9.903  1.000 33.245 0 77  TYR A O     1 ? 
ATOM   609  C CB    . TYR A 1 77  ? 1.942   9.151   -8.837  1.000 44.012 0 77  TYR A CB    1 ? 
ATOM   610  C CG    . TYR A 1 77  ? 2.213   10.551  -8.354  1.000 49.768 0 77  TYR A CG    1 ? 
ATOM   611  C CD1   . TYR A 1 77  ? 1.852   10.943  -7.074  1.000 52.006 0 77  TYR A CD1   1 ? 
ATOM   612  C CD2   . TYR A 1 77  ? 2.901   11.457  -9.140  1.000 52.014 0 77  TYR A CD2   1 ? 
ATOM   613  C CE1   . TYR A 1 77  ? 2.143   12.210  -6.594  1.000 56.360 0 77  TYR A CE1   1 ? 
ATOM   614  C CE2   . TYR A 1 77  ? 3.195   12.734  -8.680  1.000 59.963 0 77  TYR A CE2   1 ? 
ATOM   615  C CZ    . TYR A 1 77  ? 2.815   13.113  -7.402  1.000 60.594 0 77  TYR A CZ    1 ? 
ATOM   616  O OH    . TYR A 1 77  ? 3.100   14.366  -6.941  1.000 59.892 0 77  TYR A OH    1 ? 
ATOM   617  N N     . ASP A 1 78  ? 1.899   5.942   -7.970  1.000 35.313 0 78  ASP A N     1 ? 
ATOM   618  C CA    . ASP A 1 78  ? 1.358   4.597   -8.298  1.000 33.717 0 78  ASP A CA    1 ? 
ATOM   619  C C     . ASP A 1 78  ? -0.161  4.721   -8.443  1.000 34.047 0 78  ASP A C     1 ? 
ATOM   620  O O     . ASP A 1 78  ? -0.856  4.694   -7.406  1.000 29.408 0 78  ASP A O     1 ? 
ATOM   621  C CB    . ASP A 1 78  ? 1.732   3.581   -7.216  1.000 38.273 0 78  ASP A CB    1 ? 
ATOM   622  C CG    . ASP A 1 78  ? 0.943   2.286   -7.305  1.000 42.290 0 78  ASP A CG    1 ? 
ATOM   623  O OD1   . ASP A 1 78  ? 0.658   1.852   -8.447  1.000 51.858 0 78  ASP A OD1   1 ? 
ATOM   624  O OD2   . ASP A 1 78  ? 0.616   1.720   -6.242  1.000 47.005 0 78  ASP A OD2   1 ? 
ATOM   625  N N     . ILE A 1 79  ? -0.662  4.905   -9.665  1.000 28.097 0 79  ILE A N     1 ? 
ATOM   626  C CA    . ILE A 1 79  ? -2.125  5.008   -9.911  1.000 31.644 0 79  ILE A CA    1 ? 
ATOM   627  C C     . ILE A 1 79  ? -2.667  3.589   -10.135 1.000 29.810 0 79  ILE A C     1 ? 
ATOM   628  O O     . ILE A 1 79  ? -2.317  2.994   -11.159 1.000 29.963 0 79  ILE A O     1 ? 
ATOM   629  C CB    . ILE A 1 79  ? -2.442  5.926   -11.100 1.000 34.701 0 79  ILE A CB    1 ? 
ATOM   630  C CG1   . ILE A 1 79  ? -1.895  7.336   -10.889 1.000 36.434 0 79  ILE A CG1   1 ? 
ATOM   631  C CG2   . ILE A 1 79  ? -3.934  5.947   -11.377 1.000 34.154 0 79  ILE A CG2   1 ? 
ATOM   632  C CD1   . ILE A 1 79  ? -2.333  8.310   -11.959 1.000 37.030 0 79  ILE A CD1   1 ? 
ATOM   633  N N     . ASP A 1 80  ? -3.490  3.082   -9.215  1.000 25.863 0 80  ASP A N     1 ? 
ATOM   634  C CA    . ASP A 1 80  ? -4.068  1.713   -9.314  1.000 25.275 0 80  ASP A CA    1 ? 
ATOM   635  C C     . ASP A 1 80  ? -5.518  1.802   -9.789  1.000 23.146 0 80  ASP A C     1 ? 
ATOM   636  O O     . ASP A 1 80  ? -6.331  2.532   -9.168  1.000 21.820 0 80  ASP A O     1 ? 
ATOM   637  C CB    . ASP A 1 80  ? -3.950  0.954   -8.001  1.000 27.270 0 80  ASP A CB    1 ? 
ATOM   638  C CG    . ASP A 1 80  ? -2.555  0.991   -7.434  1.000 29.567 0 80  ASP A CG    1 ? 
ATOM   639  O OD1   . ASP A 1 80  ? -2.412  1.504   -6.301  1.000 32.184 0 80  ASP A OD1   1 ? 
ATOM   640  O OD2   . ASP A 1 80  ? -1.600  0.528   -8.143  1.000 33.554 0 80  ASP A OD2   1 ? 
ATOM   641  N N     . VAL A 1 81  ? -5.830  1.078   -10.861 1.000 21.042 0 81  VAL A N     1 ? 
ATOM   642  C CA    . VAL A 1 81  ? -7.201  1.001   -11.418 1.000 21.413 0 81  VAL A CA    1 ? 
ATOM   643  C C     . VAL A 1 81  ? -7.505  -0.455  -11.802 1.000 19.242 0 81  VAL A C     1 ? 
ATOM   644  O O     . VAL A 1 81  ? -6.593  -1.167  -12.259 1.000 19.065 0 81  VAL A O     1 ? 
ATOM   645  C CB    . VAL A 1 81  ? -7.392  1.973   -12.589 1.000 25.001 0 81  VAL A CB    1 ? 
ATOM   646  C CG1   . VAL A 1 81  ? -6.692  1.484   -13.835 1.000 29.968 0 81  VAL A CG1   1 ? 
ATOM   647  C CG2   . VAL A 1 81  ? -8.858  2.230   -12.866 1.000 26.595 0 81  VAL A CG2   1 ? 
ATOM   648  N N     . GLY A 1 82  ? -8.737  -0.876  -11.531 1.000 19.570 0 82  GLY A N     1 ? 
ATOM   649  C CA    . GLY A 1 82  ? -9.290  -2.161  -11.969 1.000 19.134 0 82  GLY A CA    1 ? 
ATOM   650  C C     . GLY A 1 82  ? -10.149 -1.960  -13.194 1.000 19.404 0 82  GLY A C     1 ? 
ATOM   651  O O     . GLY A 1 82  ? -10.895 -0.980  -13.230 1.000 20.024 0 82  GLY A O     1 ? 
ATOM   652  N N     . ILE A 1 83  ? -10.028 -2.834  -14.182 1.000 21.282 0 83  ILE A N     1 ? 
ATOM   653  C CA    . ILE A 1 83  ? -10.976 -2.845  -15.334 1.000 21.634 0 83  ILE A CA    1 ? 
ATOM   654  C C     . ILE A 1 83  ? -11.574 -4.249  -15.441 1.000 18.958 0 83  ILE A C     1 ? 
ATOM   655  O O     . ILE A 1 83  ? -10.814 -5.221  -15.398 1.000 22.829 0 83  ILE A O     1 ? 
ATOM   656  C CB    . ILE A 1 83  ? -10.293 -2.353  -16.623 1.000 23.415 0 83  ILE A CB    1 ? 
ATOM   657  C CG1   . ILE A 1 83  ? -9.179  -3.286  -17.081 1.000 26.702 0 83  ILE A CG1   1 ? 
ATOM   658  C CG2   . ILE A 1 83  ? -9.782  -0.925  -16.451 1.000 24.813 0 83  ILE A CG2   1 ? 
ATOM   659  C CD1   . ILE A 1 83  ? -8.591  -2.903  -18.426 1.000 27.623 0 83  ILE A CD1   1 ? 
ATOM   660  N N     . ILE A 1 84  ? -12.890 -4.340  -15.414 1.000 17.737 0 84  ILE A N     1 ? 
ATOM   661  C CA    . ILE A 1 84  ? -13.617 -5.633  -15.515 1.000 19.933 0 84  ILE A CA    1 ? 
ATOM   662  C C     . ILE A 1 84  ? -14.113 -5.759  -16.944 1.000 20.526 0 84  ILE A C     1 ? 
ATOM   663  O O     . ILE A 1 84  ? -15.096 -5.100  -17.258 1.000 22.845 0 84  ILE A O     1 ? 
ATOM   664  C CB    . ILE A 1 84  ? -14.792 -5.692  -14.554 1.000 19.598 0 84  ILE A CB    1 ? 
ATOM   665  C CG1   . ILE A 1 84  ? -14.344 -5.364  -13.121 1.000 19.981 0 84  ILE A CG1   1 ? 
ATOM   666  C CG2   . ILE A 1 84  ? -15.472 -7.039  -14.645 1.000 20.790 0 84  ILE A CG2   1 ? 
ATOM   667  C CD1   . ILE A 1 84  ? -15.478 -5.182  -12.191 1.000 20.524 0 84  ILE A CD1   1 ? 
ATOM   668  N N     . LEU A 1 85  ? -13.440 -6.560  -17.740 1.000 21.954 0 85  LEU A N     1 ? 
ATOM   669  C CA    . LEU A 1 85  ? -13.792 -6.757  -19.172 1.000 24.477 0 85  LEU A CA    1 ? 
ATOM   670  C C     . LEU A 1 85  ? -15.092 -7.557  -19.242 1.000 22.952 0 85  LEU A C     1 ? 
ATOM   671  O O     . LEU A 1 85  ? -15.306 -8.430  -18.388 1.000 21.564 0 85  LEU A O     1 ? 
ATOM   672  C CB    . LEU A 1 85  ? -12.641 -7.473  -19.880 1.000 26.502 0 85  LEU A CB    1 ? 
ATOM   673  C CG    . LEU A 1 85  ? -11.461 -6.578  -20.245 1.000 33.529 0 85  LEU A CG    1 ? 
ATOM   674  C CD1   . LEU A 1 85  ? -10.210 -7.405  -20.509 1.000 35.683 0 85  LEU A CD1   1 ? 
ATOM   675  C CD2   . LEU A 1 85  ? -11.793 -5.727  -21.454 1.000 34.481 0 85  LEU A CD2   1 ? 
ATOM   676  N N     . ASN A 1 86  ? -15.929 -7.268  -20.228 1.000 25.065 0 86  ASN A N     1 ? 
ATOM   677  C CA    . ASN A 1 86  ? -17.222 -7.958  -20.423 1.000 25.597 0 86  ASN A CA    1 ? 
ATOM   678  C C     . ASN A 1 86  ? -16.921 -9.277  -21.158 1.000 28.807 0 86  ASN A C     1 ? 
ATOM   679  O O     . ASN A 1 86  ? -17.293 -9.400  -22.363 1.000 26.932 0 86  ASN A O     1 ? 
ATOM   680  C CB    . ASN A 1 86  ? -18.203 -7.014  -21.135 1.000 29.591 0 86  ASN A CB    1 ? 
ATOM   681  C CG    . ASN A 1 86  ? -19.593 -7.588  -21.296 1.000 33.051 0 86  ASN A CG    1 ? 
ATOM   682  O OD1   . ASN A 1 86  ? -20.149 -8.183  -20.371 1.000 34.548 0 86  ASN A OD1   1 ? 
ATOM   683  N ND2   . ASN A 1 86  ? -20.179 -7.377  -22.457 1.000 35.441 0 86  ASN A ND2   1 ? 
ATOM   684  N N     . ILE A 1 87  ? -16.242 -10.211 -20.479 1.000 25.217 0 87  ILE A N     1 ? 
ATOM   685  C CA    . ILE A 1 87  ? -15.789 -11.520 -21.041 1.000 25.884 0 87  ILE A CA    1 ? 
ATOM   686  C C     . ILE A 1 87  ? -16.015 -12.610 -20.010 1.000 27.007 0 87  ILE A C     1 ? 
ATOM   687  O O     . ILE A 1 87  ? -16.018 -12.300 -18.803 1.000 24.021 0 87  ILE A O     1 ? 
ATOM   688  C CB    . ILE A 1 87  ? -14.318 -11.484 -21.455 1.000 25.628 0 87  ILE A CB    1 ? 
ATOM   689  C CG1   . ILE A 1 87  ? -13.409 -11.171 -20.264 1.000 26.313 0 87  ILE A CG1   1 ? 
ATOM   690  C CG2   . ILE A 1 87  ? -14.123 -10.503 -22.586 1.000 26.247 0 87  ILE A CG2   1 ? 
ATOM   691  C CD1   . ILE A 1 87  ? -11.934 -11.169 -20.586 1.000 25.923 0 87  ILE A CD1   1 ? 
ATOM   692  N N     . ALA A 1 88  ? -16.110 -13.846 -20.491 1.000 26.937 0 88  ALA A N     1 ? 
ATOM   693  C CA    . ALA A 1 88  ? -16.159 -15.076 -19.683 1.000 26.534 0 88  ALA A CA    1 ? 
ATOM   694  C C     . ALA A 1 88  ? -14.726 -15.547 -19.493 1.000 26.469 0 88  ALA A C     1 ? 
ATOM   695  O O     . ALA A 1 88  ? -14.029 -15.701 -20.522 1.000 25.400 0 88  ALA A O     1 ? 
ATOM   696  C CB    . ALA A 1 88  ? -16.995 -16.106 -20.394 1.000 28.599 0 88  ALA A CB    1 ? 
ATOM   697  N N     . LYS A 1 89  ? -14.286 -15.727 -18.249 1.000 24.243 0 89  LYS A N     1 ? 
ATOM   698  C CA    . LYS A 1 89  ? -12.865 -16.060 -17.935 1.000 27.600 0 89  LYS A CA    1 ? 
ATOM   699  C C     . LYS A 1 89  ? -12.518 -17.417 -18.573 1.000 26.423 0 89  LYS A C     1 ? 
ATOM   700  O O     . LYS A 1 89  ? -11.373 -17.569 -19.066 1.000 27.665 0 89  LYS A O     1 ? 
ATOM   701  C CB    . LYS A 1 89  ? -12.609 -16.070 -16.420 1.000 27.579 0 89  LYS A CB    1 ? 
ATOM   702  C CG    . LYS A 1 89  ? -13.119 -17.296 -15.685 1.000 28.683 0 89  LYS A CG    1 ? 
ATOM   703  C CD    . LYS A 1 89  ? -12.922 -17.311 -14.187 1.000 29.487 0 89  LYS A CD    1 ? 
ATOM   704  C CE    . LYS A 1 89  ? -13.416 -18.615 -13.588 1.000 34.848 0 89  LYS A CE    1 ? 
ATOM   705  N NZ    . LYS A 1 89  ? -13.455 -18.568 -12.112 1.000 40.121 0 89  LYS A NZ    1 ? 
ATOM   706  N N     . ASP A 1 90  ? -13.490 -18.327 -18.649 1.000 26.541 0 90  ASP A N     1 ? 
ATOM   707  C CA    . ASP A 1 90  ? -13.294 -19.695 -19.217 1.000 30.555 0 90  ASP A CA    1 ? 
ATOM   708  C C     . ASP A 1 90  ? -13.098 -19.630 -20.735 1.000 28.892 0 90  ASP A C     1 ? 
ATOM   709  O O     . ASP A 1 90  ? -12.658 -20.649 -21.285 1.000 30.570 0 90  ASP A O     1 ? 
ATOM   710  C CB    . ASP A 1 90  ? -14.451 -20.630 -18.830 1.000 32.351 0 90  ASP A CB    1 ? 
ATOM   711  C CG    . ASP A 1 90  ? -14.381 -21.074 -17.378 1.000 36.786 0 90  ASP A CG    1 ? 
ATOM   712  O OD1   . ASP A 1 90  ? -15.388 -21.628 -16.881 1.000 41.095 0 90  ASP A OD1   1 ? 
ATOM   713  O OD2   . ASP A 1 90  ? -13.309 -20.872 -16.759 1.000 36.061 0 90  ASP A OD2   1 ? 
ATOM   714  N N     . ASP A 1 91  ? -13.361 -18.485 -21.389 1.000 27.790 0 91  ASP A N     1 ? 
ATOM   715  C CA    . ASP A 1 91  ? -13.270 -18.353 -22.873 1.000 29.439 0 91  ASP A CA    1 ? 
ATOM   716  C C     . ASP A 1 91  ? -11.884 -17.866 -23.296 1.000 28.829 0 91  ASP A C     1 ? 
ATOM   717  O O     . ASP A 1 91  ? -11.643 -17.852 -24.501 1.000 28.940 0 91  ASP A O     1 ? 
ATOM   718  C CB    . ASP A 1 91  ? -14.318 -17.393 -23.458 1.000 30.519 0 91  ASP A CB    1 ? 
ATOM   719  C CG    . ASP A 1 91  ? -15.722 -17.963 -23.457 1.000 33.197 0 91  ASP A CG    1 ? 
ATOM   720  O OD1   . ASP A 1 91  ? -15.845 -19.168 -23.207 1.000 31.890 0 91  ASP A OD1   1 ? 
ATOM   721  O OD2   . ASP A 1 91  ? -16.686 -17.191 -23.719 1.000 36.930 0 91  ASP A OD2   1 ? 
ATOM   722  N N     . HIS A 1 92  ? -11.031 -17.434 -22.359 1.000 26.170 0 92  HIS A N     1 ? 
ATOM   723  C CA    . HIS A 1 92  ? -9.769  -16.709 -22.658 1.000 25.260 0 92  HIS A CA    1 ? 
ATOM   724  C C     . HIS A 1 92  ? -8.680  -17.096 -21.664 1.000 30.207 0 92  HIS A C     1 ? 
ATOM   725  O O     . HIS A 1 92  ? -8.990  -17.426 -20.490 1.000 29.089 0 92  HIS A O     1 ? 
ATOM   726  C CB    . HIS A 1 92  ? -9.965  -15.187 -22.690 1.000 26.709 0 92  HIS A CB    1 ? 
ATOM   727  C CG    . HIS A 1 92  ? -11.123 -14.733 -23.515 1.000 27.722 0 92  HIS A CG    1 ? 
ATOM   728  N ND1   . HIS A 1 92  ? -11.019 -14.494 -24.868 1.000 28.743 0 92  HIS A ND1   1 ? 
ATOM   729  C CD2   . HIS A 1 92  ? -12.408 -14.474 -23.179 1.000 27.267 0 92  HIS A CD2   1 ? 
ATOM   730  C CE1   . HIS A 1 92  ? -12.198 -14.117 -25.334 1.000 30.173 0 92  HIS A CE1   1 ? 
ATOM   731  N NE2   . HIS A 1 92  ? -13.069 -14.096 -24.310 1.000 27.521 0 92  HIS A NE2   1 ? 
ATOM   732  N N     . ASP A 1 93  ? -7.436  -17.059 -22.124 1.000 28.257 0 93  ASP A N     1 ? 
ATOM   733  C CA    . ASP A 1 93  ? -6.262  -17.252 -21.254 1.000 28.864 0 93  ASP A CA    1 ? 
ATOM   734  C C     . ASP A 1 93  ? -5.974  -15.900 -20.601 1.000 24.053 0 93  ASP A C     1 ? 
ATOM   735  O O     . ASP A 1 93  ? -6.172  -14.854 -21.216 1.000 22.534 0 93  ASP A O     1 ? 
ATOM   736  C CB    . ASP A 1 93  ? -5.130  -17.869 -22.067 1.000 34.250 0 93  ASP A CB    1 ? 
ATOM   737  C CG    . ASP A 1 93  ? -3.775  -17.746 -21.426 1.000 35.830 0 93  ASP A CG    1 ? 
ATOM   738  O OD1   . ASP A 1 93  ? -3.376  -18.715 -20.738 1.000 39.616 0 93  ASP A OD1   1 ? 
ATOM   739  O OD2   . ASP A 1 93  ? -3.120  -16.700 -21.653 1.000 34.325 0 93  ASP A OD2   1 ? 
ATOM   740  N N     . PRO A 1 94  ? -5.576  -15.863 -19.312 1.000 23.323 0 94  PRO A N     1 ? 
ATOM   741  C CA    . PRO A 1 94  ? -5.412  -14.586 -18.618 1.000 26.811 0 94  PRO A CA    1 ? 
ATOM   742  C C     . PRO A 1 94  ? -4.283  -13.746 -19.225 1.000 28.619 0 94  PRO A C     1 ? 
ATOM   743  O O     . PRO A 1 94  ? -4.425  -12.513 -19.312 1.000 25.198 0 94  PRO A O     1 ? 
ATOM   744  C CB    . PRO A 1 94  ? -5.136  -14.994 -17.163 1.000 26.814 0 94  PRO A CB    1 ? 
ATOM   745  C CG    . PRO A 1 94  ? -4.613  -16.405 -17.265 1.000 27.838 0 94  PRO A CG    1 ? 
ATOM   746  C CD    . PRO A 1 94  ? -5.346  -17.021 -18.440 1.000 25.805 0 94  PRO A CD    1 ? 
ATOM   747  N N     . VAL A 1 95  ? -3.208  -14.406 -19.691 1.000 25.854 0 95  VAL A N     1 ? 
ATOM   748  C CA    . VAL A 1 95  ? -2.076  -13.698 -20.362 1.000 28.410 0 95  VAL A CA    1 ? 
ATOM   749  C C     . VAL A 1 95  ? -2.575  -13.129 -21.701 1.000 28.276 0 95  VAL A C     1 ? 
ATOM   750  O O     . VAL A 1 95  ? -2.147  -12.052 -22.055 1.000 28.816 0 95  VAL A O     1 ? 
ATOM   751  C CB    . VAL A 1 95  ? -0.868  -14.628 -20.558 1.000 29.925 0 95  VAL A CB    1 ? 
ATOM   752  C CG1   . VAL A 1 95  ? 0.220   -13.966 -21.386 1.000 33.003 0 95  VAL A CG1   1 ? 
ATOM   753  C CG2   . VAL A 1 95  ? -0.330  -15.094 -19.211 1.000 30.137 0 95  VAL A CG2   1 ? 
ATOM   754  N N     . GLU A 1 96  ? -3.371  -13.908 -22.440 1.000 31.069 0 96  GLU A N     1 ? 
ATOM   755  C CA    . GLU A 1 96  ? -4.052  -13.511 -23.712 1.000 29.595 0 96  GLU A CA    1 ? 
ATOM   756  C C     . GLU A 1 96  ? -4.792  -12.187 -23.480 1.000 29.176 0 96  GLU A C     1 ? 
ATOM   757  O O     . GLU A 1 96  ? -4.628  -11.239 -24.283 1.000 27.687 0 96  GLU A O     1 ? 
ATOM   758  C CB    . GLU A 1 96  ? -4.979  -14.664 -24.139 1.000 32.434 0 96  GLU A CB    1 ? 
ATOM   759  C CG    . GLU A 1 96  ? -5.797  -14.419 -25.403 1.000 33.962 0 96  GLU A CG    1 ? 
ATOM   760  C CD    . GLU A 1 96  ? -6.713  -15.582 -25.806 1.000 37.041 0 96  GLU A CD    1 ? 
ATOM   761  O OE1   . GLU A 1 96  ? -7.111  -15.631 -26.990 1.000 44.018 0 96  GLU A OE1   1 ? 
ATOM   762  O OE2   . GLU A 1 96  ? -7.015  -16.465 -24.949 1.000 37.855 0 96  GLU A OE2   1 ? 
ATOM   763  N N     . VAL A 1 97  ? -5.571  -12.108 -22.398 1.000 29.004 0 97  VAL A N     1 ? 
ATOM   764  C CA    . VAL A 1 97  ? -6.415  -10.920 -22.107 1.000 28.858 0 97  VAL A CA    1 ? 
ATOM   765  C C     . VAL A 1 97  ? -5.502  -9.754  -21.710 1.000 27.247 0 97  VAL A C     1 ? 
ATOM   766  O O     . VAL A 1 97  ? -5.739  -8.620  -22.161 1.000 24.940 0 97  VAL A O     1 ? 
ATOM   767  C CB    . VAL A 1 97  ? -7.461  -11.226 -21.025 1.000 31.025 0 97  VAL A CB    1 ? 
ATOM   768  C CG1   . VAL A 1 97  ? -8.271  -9.984  -20.681 1.000 32.200 0 97  VAL A CG1   1 ? 
ATOM   769  C CG2   . VAL A 1 97  ? -8.389  -12.349 -21.468 1.000 32.600 0 97  VAL A CG2   1 ? 
ATOM   770  N N     . LYS A 1 98  ? -4.478  -10.011 -20.905 1.000 27.456 0 98  LYS A N     1 ? 
ATOM   771  C CA    . LYS A 1 98  ? -3.531  -8.939  -20.525 1.000 27.522 0 98  LYS A CA    1 ? 
ATOM   772  C C     . LYS A 1 98  ? -2.841  -8.435  -21.805 1.000 29.685 0 98  LYS A C     1 ? 
ATOM   773  O O     . LYS A 1 98  ? -2.627  -7.211  -21.924 1.000 27.746 0 98  LYS A O     1 ? 
ATOM   774  C CB    . LYS A 1 98  ? -2.577  -9.428  -19.435 1.000 27.389 0 98  LYS A CB    1 ? 
ATOM   775  C CG    . LYS A 1 98  ? -3.162  -9.378  -18.023 1.000 28.238 0 98  LYS A CG    1 ? 
ATOM   776  C CD    . LYS A 1 98  ? -2.110  -9.517  -16.897 1.000 28.892 0 98  LYS A CD    1 ? 
ATOM   777  C CE    . LYS A 1 98  ? -1.607  -10.929 -16.721 1.000 31.578 0 98  LYS A CE    1 ? 
ATOM   778  N NZ    . LYS A 1 98  ? -0.742  -11.063 -15.522 1.000 30.501 0 98  LYS A NZ    1 ? 
ATOM   779  N N     . LYS A 1 99  ? -2.536  -9.330  -22.754 1.000 27.376 0 99  LYS A N     1 ? 
ATOM   780  C CA    . LYS A 1 99  ? -1.908  -8.922  -24.045 1.000 29.668 0 99  LYS A CA    1 ? 
ATOM   781  C C     . LYS A 1 99  ? -2.778  -7.862  -24.740 1.000 26.288 0 99  LYS A C     1 ? 
ATOM   782  O O     . LYS A 1 99  ? -2.248  -6.835  -25.109 1.000 28.766 0 99  LYS A O     1 ? 
ATOM   783  C CB    . LYS A 1 99  ? -1.666  -10.123 -24.958 1.000 32.869 0 99  LYS A CB    1 ? 
ATOM   784  C CG    . LYS A 1 99  ? -0.898  -9.765  -26.220 1.000 35.371 0 99  LYS A CG    1 ? 
ATOM   785  C CD    . LYS A 1 99  ? 0.088   -10.804 -26.656 1.000 38.130 0 99  LYS A CD    1 ? 
ATOM   786  C CE    . LYS A 1 99  ? 0.488   -10.638 -28.108 1.000 43.097 0 99  LYS A CE    1 ? 
ATOM   787  N NZ    . LYS A 1 99  ? 1.257   -9.392  -28.334 1.000 43.989 0 99  LYS A NZ    1 ? 
ATOM   788  N N     . TRP A 1 100 ? -4.080  -8.081  -24.879 1.000 29.564 0 100 TRP A N     1 ? 
ATOM   789  C CA    . TRP A 1 100 ? -5.006  -7.069  -25.466 1.000 27.214 0 100 TRP A CA    1 ? 
ATOM   790  C C     . TRP A 1 100 ? -4.715  -5.695  -24.882 1.000 30.644 0 100 TRP A C     1 ? 
ATOM   791  O O     . TRP A 1 100 ? -4.722  -4.725  -25.656 1.000 27.430 0 100 TRP A O     1 ? 
ATOM   792  C CB    . TRP A 1 100 ? -6.470  -7.390  -25.217 1.000 28.869 0 100 TRP A CB    1 ? 
ATOM   793  C CG    . TRP A 1 100 ? -6.941  -8.733  -25.686 1.000 30.573 0 100 TRP A CG    1 ? 
ATOM   794  C CD1   . TRP A 1 100 ? -6.334  -9.592  -26.563 1.000 30.155 0 100 TRP A CD1   1 ? 
ATOM   795  C CD2   . TRP A 1 100 ? -8.174  -9.354  -25.302 1.000 30.671 0 100 TRP A CD2   1 ? 
ATOM   796  N NE1   . TRP A 1 100 ? -7.097  -10.720 -26.716 1.000 31.975 0 100 TRP A NE1   1 ? 
ATOM   797  C CE2   . TRP A 1 100 ? -8.233  -10.602 -25.959 1.000 32.405 0 100 TRP A CE2   1 ? 
ATOM   798  C CE3   . TRP A 1 100 ? -9.224  -8.986  -24.453 1.000 30.367 0 100 TRP A CE3   1 ? 
ATOM   799  C CZ2   . TRP A 1 100 ? -9.313  -11.471 -25.804 1.000 29.833 0 100 TRP A CZ2   1 ? 
ATOM   800  C CZ3   . TRP A 1 100 ? -10.284 -9.848  -24.299 1.000 33.052 0 100 TRP A CZ3   1 ? 
ATOM   801  C CH2   . TRP A 1 100 ? -10.322 -11.079 -24.961 1.000 31.136 0 100 TRP A CH2   1 ? 
ATOM   802  N N     . ILE A 1 101 ? -4.598  -5.605  -23.546 1.000 25.796 0 101 ILE A N     1 ? 
ATOM   803  C CA    . ILE A 1 101 ? -4.480  -4.294  -22.842 1.000 27.002 0 101 ILE A CA    1 ? 
ATOM   804  C C     . ILE A 1 101 ? -3.073  -3.736  -23.081 1.000 27.630 0 101 ILE A C     1 ? 
ATOM   805  O O     . ILE A 1 101 ? -2.970  -2.545  -23.412 1.000 26.600 0 101 ILE A O     1 ? 
ATOM   806  C CB    . ILE A 1 101 ? -4.818  -4.430  -21.339 1.000 24.017 0 101 ILE A CB    1 ? 
ATOM   807  C CG1   . ILE A 1 101 ? -6.225  -4.996  -21.132 1.000 23.767 0 101 ILE A CG1   1 ? 
ATOM   808  C CG2   . ILE A 1 101 ? -4.623  -3.109  -20.609 1.000 23.443 0 101 ILE A CG2   1 ? 
ATOM   809  C CD1   . ILE A 1 101 ? -7.338  -4.154  -21.697 1.000 24.316 0 101 ILE A CD1   1 ? 
ATOM   810  N N     . ARG A 1 102 ? -2.037  -4.566  -22.963 1.000 30.872 0 102 ARG A N     1 ? 
ATOM   811  C CA    . ARG A 1 102 ? -0.638  -4.117  -23.219 1.000 36.337 0 102 ARG A CA    1 ? 
ATOM   812  C C     . ARG A 1 102 ? -0.567  -3.550  -24.633 1.000 37.827 0 102 ARG A C     1 ? 
ATOM   813  O O     . ARG A 1 102 ? -0.089  -2.413  -24.774 1.000 34.765 0 102 ARG A O     1 ? 
ATOM   814  C CB    . ARG A 1 102 ? 0.412   -5.226  -23.065 1.000 42.790 0 102 ARG A CB    1 ? 
ATOM   815  C CG    . ARG A 1 102 ? 1.714   -4.883  -23.789 1.000 51.289 0 102 ARG A CG    1 ? 
ATOM   816  C CD    . ARG A 1 102 ? 2.948   -5.643  -23.355 1.000 56.531 0 102 ARG A CD    1 ? 
ATOM   817  N NE    . ARG A 1 102 ? 2.936   -7.051  -23.735 1.000 65.480 0 102 ARG A NE    1 ? 
ATOM   818  C CZ    . ARG A 1 102 ? 3.084   -7.520  -24.973 1.000 66.374 0 102 ARG A CZ    1 ? 
ATOM   819  N NH1   . ARG A 1 102 ? 3.059   -8.825  -25.186 1.000 69.411 0 102 ARG A NH1   1 ? 
ATOM   820  N NH2   . ARG A 1 102 ? 3.232   -6.695  -25.994 1.000 74.158 0 102 ARG A NH2   1 ? 
ATOM   821  N N     . ASP A 1 103 ? -1.027  -4.328  -25.626 1.000 40.028 0 103 ASP A N     1 ? 
ATOM   822  C CA    . ASP A 1 103 ? -0.991  -3.945  -27.067 1.000 40.856 0 103 ASP A CA    1 ? 
ATOM   823  C C     . ASP A 1 103 ? -1.837  -2.684  -27.239 1.000 35.293 0 103 ASP A C     1 ? 
ATOM   824  O O     . ASP A 1 103 ? -1.379  -1.788  -27.942 1.000 36.909 0 103 ASP A O     1 ? 
ATOM   825  C CB    . ASP A 1 103 ? -1.421  -5.092  -27.996 1.000 39.045 0 103 ASP A CB    1 ? 
ATOM   826  C CG    . ASP A 1 103 ? -0.470  -6.288  -27.966 1.000 40.756 0 103 ASP A CG    1 ? 
ATOM   827  O OD1   . ASP A 1 103 ? -0.852  -7.346  -28.477 1.000 35.664 0 103 ASP A OD1   1 ? 
ATOM   828  O OD2   . ASP A 1 103 ? 0.639   -6.158  -27.401 1.000 40.052 0 103 ASP A OD2   1 ? 
ATOM   829  N N     . ALA A 1 104 ? -2.977  -2.594  -26.549 1.000 33.822 0 104 ALA A N     1 ? 
ATOM   830  C CA    . ALA A 1 104 ? -3.832  -1.389  -26.520 1.000 36.186 0 104 ALA A CA    1 ? 
ATOM   831  C C     . ALA A 1 104 ? -2.968  -0.167  -26.196 1.000 37.127 0 104 ALA A C     1 ? 
ATOM   832  O O     . ALA A 1 104 ? -3.138  0.892   -26.865 1.000 37.690 0 104 ALA A O     1 ? 
ATOM   833  C CB    . ALA A 1 104 ? -4.939  -1.565  -25.522 1.000 37.479 0 104 ALA A CB    1 ? 
ATOM   834  N N     . LEU A 1 105 ? -2.068  -0.302  -25.215 1.000 40.232 0 105 LEU A N     1 ? 
ATOM   835  C CA    . LEU A 1 105 ? -1.303  0.839   -24.624 1.000 42.093 0 105 LEU A CA    1 ? 
ATOM   836  C C     . LEU A 1 105 ? 0.142   0.861   -25.149 1.000 44.197 0 105 LEU A C     1 ? 
ATOM   837  O O     . LEU A 1 105 ? 0.965   1.585   -24.564 1.000 41.203 0 105 LEU A O     1 ? 
ATOM   838  C CB    . LEU A 1 105 ? -1.328  0.716   -23.099 1.000 39.306 0 105 LEU A CB    1 ? 
ATOM   839  C CG    . LEU A 1 105 ? -2.703  0.879   -22.453 1.000 41.257 0 105 LEU A CG    1 ? 
ATOM   840  C CD1   . LEU A 1 105 ? -2.632  0.605   -20.963 1.000 40.923 0 105 LEU A CD1   1 ? 
ATOM   841  C CD2   . LEU A 1 105 ? -3.271  2.266   -22.708 1.000 38.331 0 105 LEU A CD2   1 ? 
ATOM   842  N N     . LYS A 1 106 ? 0.431   0.141   -26.234 1.000 48.230 0 106 LYS A N     1 ? 
ATOM   843  C CA    . LYS A 1 106 ? 1.805   0.035   -26.802 1.000 59.300 0 106 LYS A CA    1 ? 
ATOM   844  C C     . LYS A 1 106 ? 2.359   1.452   -27.045 1.000 59.960 0 106 LYS A C     1 ? 
ATOM   845  O O     . LYS A 1 106 ? 3.553   1.664   -26.785 1.000 57.681 0 106 LYS A O     1 ? 
ATOM   846  C CB    . LYS A 1 106 ? 1.802   -0.810  -28.085 1.000 66.294 0 106 LYS A CB    1 ? 
ATOM   847  C CG    . LYS A 1 106 ? 2.987   -1.760  -28.251 1.000 74.574 0 106 LYS A CG    1 ? 
ATOM   848  C CD    . LYS A 1 106 ? 4.167   -1.161  -29.008 1.000 78.018 0 106 LYS A CD    1 ? 
ATOM   849  C CE    . LYS A 1 106 ? 5.229   -2.183  -29.362 1.000 80.024 0 106 LYS A CE    1 ? 
ATOM   850  N NZ    . LYS A 1 106 ? 6.080   -1.726  -30.486 1.000 79.044 0 106 LYS A NZ    1 ? 
ATOM   851  N N     . ASP A 1 107 ? 1.507   2.391   -27.481 1.000 64.663 0 107 ASP A N     1 ? 
ATOM   852  C CA    . ASP A 1 107 ? 1.913   3.727   -28.001 1.000 69.220 0 107 ASP A CA    1 ? 
ATOM   853  C C     . ASP A 1 107 ? 1.675   4.820   -26.947 1.000 66.380 0 107 ASP A C     1 ? 
ATOM   854  O O     . ASP A 1 107 ? 1.890   6.001   -27.281 1.000 57.498 0 107 ASP A O     1 ? 
ATOM   855  C CB    . ASP A 1 107 ? 1.162   4.061   -29.294 1.000 75.045 0 107 ASP A CB    1 ? 
ATOM   856  C CG    . ASP A 1 107 ? 1.255   2.979   -30.359 1.000 78.960 0 107 ASP A CG    1 ? 
ATOM   857  O OD1   . ASP A 1 107 ? 1.965   3.203   -31.360 1.000 76.150 0 107 ASP A OD1   1 ? 
ATOM   858  O OD2   . ASP A 1 107 ? 0.603   1.925   -30.185 1.000 86.662 0 107 ASP A OD2   1 ? 
ATOM   859  N N     . TYR A 1 108 ? 1.240   4.450   -25.737 1.000 64.138 0 108 TYR A N     1 ? 
ATOM   860  C CA    . TYR A 1 108 ? 0.971   5.386   -24.611 1.000 57.716 0 108 TYR A CA    1 ? 
ATOM   861  C C     . TYR A 1 108 ? 2.258   5.558   -23.795 1.000 54.534 0 108 TYR A C     1 ? 
ATOM   862  O O     . TYR A 1 108 ? 2.901   4.533   -23.463 1.000 49.170 0 108 TYR A O     1 ? 
ATOM   863  C CB    . TYR A 1 108 ? -0.189  4.884   -23.745 1.000 56.118 0 108 TYR A CB    1 ? 
ATOM   864  C CG    . TYR A 1 108 ? -0.815  5.942   -22.871 1.000 54.023 0 108 TYR A CG    1 ? 
ATOM   865  C CD1   . TYR A 1 108 ? -1.693  6.872   -23.398 1.000 53.086 0 108 TYR A CD1   1 ? 
ATOM   866  C CD2   . TYR A 1 108 ? -0.512  6.032   -21.521 1.000 55.351 0 108 TYR A CD2   1 ? 
ATOM   867  C CE1   . TYR A 1 108 ? -2.273  7.847   -22.605 1.000 55.016 0 108 TYR A CE1   1 ? 
ATOM   868  C CE2   . TYR A 1 108 ? -1.073  7.009   -20.714 1.000 52.733 0 108 TYR A CE2   1 ? 
ATOM   869  C CZ    . TYR A 1 108 ? -1.962  7.918   -21.256 1.000 56.027 0 108 TYR A CZ    1 ? 
ATOM   870  O OH    . TYR A 1 108 ? -2.528  8.885   -20.472 1.000 50.812 0 108 TYR A OH    1 ? 
ATOM   871  N N     . GLY A 1 109 ? 2.631   6.812   -23.512 1.000 50.219 0 109 GLY A N     1 ? 
ATOM   872  C CA    . GLY A 1 109 ? 3.795   7.164   -22.674 1.000 50.657 0 109 GLY A CA    1 ? 
ATOM   873  C C     . GLY A 1 109 ? 5.042   6.422   -23.112 1.000 54.530 0 109 GLY A C     1 ? 
ATOM   874  O O     . GLY A 1 109 ? 5.284   6.364   -24.321 1.000 49.233 0 109 GLY A O     1 ? 
ATOM   875  N N     . ASN A 1 110 ? 5.788   5.840   -22.167 1.000 58.234 0 110 ASN A N     1 ? 
ATOM   876  C CA    . ASN A 1 110 ? 7.136   5.260   -22.421 1.000 63.205 0 110 ASN A CA    1 ? 
ATOM   877  C C     . ASN A 1 110 ? 7.010   3.798   -22.850 1.000 65.565 0 110 ASN A C     1 ? 
ATOM   878  O O     . ASN A 1 110 ? 7.880   3.346   -23.629 1.000 74.144 0 110 ASN A O     1 ? 
ATOM   879  C CB    . ASN A 1 110 ? 8.063   5.423   -21.217 1.000 63.951 0 110 ASN A CB    1 ? 
ATOM   880  C CG    . ASN A 1 110 ? 8.695   6.798   -21.163 1.000 70.552 0 110 ASN A CG    1 ? 
ATOM   881  O OD1   . ASN A 1 110 ? 8.732   7.430   -20.108 1.000 68.618 0 110 ASN A OD1   1 ? 
ATOM   882  N ND2   . ASN A 1 110 ? 9.186   7.275   -22.298 1.000 75.385 0 110 ASN A ND2   1 ? 
ATOM   883  N N     . GLY A 1 111 ? 5.970   3.098   -22.385 1.000 62.578 0 111 GLY A N     1 ? 
ATOM   884  C CA    . GLY A 1 111 ? 5.688   1.698   -22.761 1.000 58.590 0 111 GLY A CA    1 ? 
ATOM   885  C C     . GLY A 1 111 ? 4.620   1.059   -21.887 1.000 56.420 0 111 GLY A C     1 ? 
ATOM   886  O O     . GLY A 1 111 ? 4.128   1.723   -20.955 1.000 58.684 0 111 GLY A O     1 ? 
ATOM   887  N N     . ALA A 1 112 ? 4.260   -0.185  -22.205 1.000 50.700 0 112 ALA A N     1 ? 
ATOM   888  C CA    . ALA A 1 112 ? 3.289   -1.025  -21.469 1.000 47.438 0 112 ALA A CA    1 ? 
ATOM   889  C C     . ALA A 1 112 ? 3.864   -2.442  -21.326 1.000 46.193 0 112 ALA A C     1 ? 
ATOM   890  O O     . ALA A 1 112 ? 4.625   -2.896  -22.206 1.000 46.662 0 112 ALA A O     1 ? 
ATOM   891  C CB    . ALA A 1 112 ? 1.957   -1.019  -22.174 1.000 45.478 0 112 ALA A CB    1 ? 
ATOM   892  N N     . GLU A 1 113 ? 3.501   -3.129  -20.257 1.000 43.538 0 113 GLU A N     1 ? 
ATOM   893  C CA    . GLU A 1 113 ? 4.240   -4.304  -19.745 1.000 43.022 0 113 GLU A CA    1 ? 
ATOM   894  C C     . GLU A 1 113 ? 3.249   -5.238  -19.055 1.000 36.041 0 113 GLU A C     1 ? 
ATOM   895  O O     . GLU A 1 113 ? 2.491   -4.737  -18.224 1.000 37.566 0 113 GLU A O     1 ? 
ATOM   896  C CB    . GLU A 1 113 ? 5.301   -3.794  -18.771 1.000 47.417 0 113 GLU A CB    1 ? 
ATOM   897  C CG    . GLU A 1 113 ? 6.478   -4.717  -18.585 1.000 53.990 0 113 GLU A CG    1 ? 
ATOM   898  C CD    . GLU A 1 113 ? 7.620   -4.048  -17.838 1.000 62.176 0 113 GLU A CD    1 ? 
ATOM   899  O OE1   . GLU A 1 113 ? 7.968   -2.892  -18.190 1.000 62.295 0 113 GLU A OE1   1 ? 
ATOM   900  O OE2   . GLU A 1 113 ? 8.135   -4.662  -16.881 1.000 73.402 0 113 GLU A OE2   1 ? 
ATOM   901  N N     . ILE A 1 114 ? 3.270   -6.524  -19.396 1.000 33.040 0 114 ILE A N     1 ? 
ATOM   902  C CA    . ILE A 1 114 ? 2.466   -7.582  -18.728 1.000 35.808 0 114 ILE A CA    1 ? 
ATOM   903  C C     . ILE A 1 114 ? 3.237   -8.032  -17.488 1.000 38.091 0 114 ILE A C     1 ? 
ATOM   904  O O     . ILE A 1 114 ? 4.304   -8.674  -17.655 1.000 36.328 0 114 ILE A O     1 ? 
ATOM   905  C CB    . ILE A 1 114 ? 2.169   -8.769  -19.659 1.000 39.891 0 114 ILE A CB    1 ? 
ATOM   906  C CG1   . ILE A 1 114 ? 1.161   -8.396  -20.747 1.000 40.149 0 114 ILE A CG1   1 ? 
ATOM   907  C CG2   . ILE A 1 114 ? 1.703   -9.983  -18.858 1.000 42.490 0 114 ILE A CG2   1 ? 
ATOM   908  C CD1   . ILE A 1 114 ? 1.106   -9.384  -21.879 1.000 41.828 0 114 ILE A CD1   1 ? 
ATOM   909  N N     . ARG A 1 115 ? 2.700   -7.740  -16.298 1.000 31.537 0 115 ARG A N     1 ? 
ATOM   910  C CA    . ARG A 1 115 ? 3.276   -8.201  -15.012 1.000 31.164 0 115 ARG A CA    1 ? 
ATOM   911  C C     . ARG A 1 115 ? 2.431   -9.336  -14.437 1.000 29.628 0 115 ARG A C     1 ? 
ATOM   912  O O     . ARG A 1 115 ? 1.353   -9.596  -14.964 1.000 28.256 0 115 ARG A O     1 ? 
ATOM   913  C CB    . ARG A 1 115 ? 3.324   -7.047  -14.021 1.000 38.042 0 115 ARG A CB    1 ? 
ATOM   914  C CG    . ARG A 1 115 ? 4.014   -5.799  -14.547 1.000 42.866 0 115 ARG A CG    1 ? 
ATOM   915  C CD    . ARG A 1 115 ? 4.183   -4.855  -13.380 1.000 52.637 0 115 ARG A CD    1 ? 
ATOM   916  N NE    . ARG A 1 115 ? 5.490   -4.237  -13.337 1.000 60.576 0 115 ARG A NE    1 ? 
ATOM   917  C CZ    . ARG A 1 115 ? 6.134   -3.931  -12.218 1.000 70.370 0 115 ARG A CZ    1 ? 
ATOM   918  N NH1   . ARG A 1 115 ? 5.591   -4.201  -11.037 1.000 69.754 0 115 ARG A NH1   1 ? 
ATOM   919  N NH2   . ARG A 1 115 ? 7.334   -3.378  -12.285 1.000 74.721 0 115 ARG A NH2   1 ? 
ATOM   920  N N     . ARG A 1 116 ? 2.890   -9.946  -13.353 1.000 27.261 0 116 ARG A N     1 ? 
ATOM   921  C CA    . ARG A 1 116 ? 2.253   -11.146 -12.778 1.000 29.402 0 116 ARG A CA    1 ? 
ATOM   922  C C     . ARG A 1 116 ? 0.779   -10.822 -12.500 1.000 29.347 0 116 ARG A C     1 ? 
ATOM   923  O O     . ARG A 1 116 ? -0.062  -11.679 -12.813 1.000 25.801 0 116 ARG A O     1 ? 
ATOM   924  C CB    . ARG A 1 116 ? 3.040   -11.632 -11.563 1.000 34.975 0 116 ARG A CB    1 ? 
ATOM   925  C CG    . ARG A 1 116 ? 4.243   -12.482 -11.948 1.000 43.782 0 116 ARG A CG    1 ? 
ATOM   926  C CD    . ARG A 1 116 ? 5.197   -12.832 -10.810 1.000 54.166 0 116 ARG A CD    1 ? 
ATOM   927  N NE    . ARG A 1 116 ? 5.554   -14.255 -10.837 1.000 62.971 0 116 ARG A NE    1 ? 
ATOM   928  C CZ    . ARG A 1 116 ? 6.537   -14.824 -10.130 1.000 69.104 0 116 ARG A CZ    1 ? 
ATOM   929  N NH1   . ARG A 1 116 ? 7.310   -14.098 -9.337  1.000 67.795 0 116 ARG A NH1   1 ? 
ATOM   930  N NH2   . ARG A 1 116 ? 6.745   -16.128 -10.230 1.000 67.510 0 116 ARG A NH2   1 ? 
ATOM   931  N N     . SER A 1 117 ? 0.467   -9.602  -12.031 1.000 30.111 0 117 SER A N     1 ? 
ATOM   932  C CA    . SER A 1 117 ? -0.887  -9.240  -11.515 1.000 30.036 0 117 SER A CA    1 ? 
ATOM   933  C C     . SER A 1 117 ? -1.519  -8.042  -12.238 1.000 27.843 0 117 SER A C     1 ? 
ATOM   934  O O     . SER A 1 117 ? -2.658  -7.662  -11.890 1.000 29.575 0 117 SER A O     1 ? 
ATOM   935  C CB    . SER A 1 117 ? -0.803  -9.005  -10.034 1.000 31.977 0 117 SER A CB    1 ? 
ATOM   936  O OG    . SER A 1 117 ? -0.281  -10.163 -9.403  1.000 34.554 0 117 SER A OG    1 ? 
ATOM   937  N N     . CYS A 1 118 ? -0.850  -7.436  -13.206 1.000 26.342 0 118 CYS A N     1 ? 
ATOM   938  C CA    . CYS A 1 118 ? -1.399  -6.246  -13.893 1.000 24.902 0 118 CYS A CA    1 ? 
ATOM   939  C C     . CYS A 1 118 ? -0.695  -6.031  -15.232 1.000 27.023 0 118 CYS A C     1 ? 
ATOM   940  O O     . CYS A 1 118 ? 0.282   -6.752  -15.537 1.000 28.316 0 118 CYS A O     1 ? 
ATOM   941  C CB    . CYS A 1 118 ? -1.307  -4.987  -13.030 1.000 27.424 0 118 CYS A CB    1 ? 
ATOM   942  S SG    . CYS A 1 118 ? 0.386   -4.439  -12.679 1.000 31.040 0 118 CYS A SG    1 ? 
ATOM   943  N N     . VAL A 1 119 ? -1.249  -5.128  -16.014 1.000 26.787 0 119 VAL A N     1 ? 
ATOM   944  C CA    . VAL A 1 119 ? -0.520  -4.403  -17.077 1.000 32.623 0 119 VAL A CA    1 ? 
ATOM   945  C C     . VAL A 1 119 ? -0.123  -3.046  -16.494 1.000 31.014 0 119 VAL A C     1 ? 
ATOM   946  O O     . VAL A 1 119 ? -1.025  -2.320  -16.029 1.000 32.627 0 119 VAL A O     1 ? 
ATOM   947  C CB    . VAL A 1 119 ? -1.382  -4.275  -18.347 1.000 32.305 0 119 VAL A CB    1 ? 
ATOM   948  C CG1   . VAL A 1 119 ? -0.720  -3.387  -19.388 1.000 36.022 0 119 VAL A CG1   1 ? 
ATOM   949  C CG2   . VAL A 1 119 ? -1.692  -5.659  -18.925 1.000 31.192 0 119 VAL A CG2   1 ? 
ATOM   950  N N     . THR A 1 120 ? 1.171   -2.737  -16.509 1.000 30.923 0 120 THR A N     1 ? 
ATOM   951  C CA    . THR A 1 120 ? 1.722   -1.429  -16.065 1.000 34.810 0 120 THR A CA    1 ? 
ATOM   952  C C     . THR A 1 120 ? 2.127   -0.610  -17.292 1.000 38.685 0 120 THR A C     1 ? 
ATOM   953  O O     . THR A 1 120 ? 2.941   -1.125  -18.108 1.000 33.575 0 120 THR A O     1 ? 
ATOM   954  C CB    . THR A 1 120 ? 2.935   -1.597  -15.142 1.000 41.922 0 120 THR A CB    1 ? 
ATOM   955  O OG1   . THR A 1 120 ? 2.608   -2.515  -14.100 1.000 42.553 0 120 THR A OG1   1 ? 
ATOM   956  C CG2   . THR A 1 120 ? 3.377   -0.289  -14.530 1.000 39.272 0 120 THR A CG2   1 ? 
ATOM   957  N N     . VAL A 1 121 ? 1.607   0.613   -17.393 1.000 41.398 0 121 VAL A N     1 ? 
ATOM   958  C CA    . VAL A 1 121 ? 2.035   1.627   -18.397 1.000 46.264 0 121 VAL A CA    1 ? 
ATOM   959  C C     . VAL A 1 121 ? 2.806   2.747   -17.675 1.000 47.974 0 121 VAL A C     1 ? 
ATOM   960  O O     . VAL A 1 121 ? 2.419   3.121   -16.538 1.000 41.219 0 121 VAL A O     1 ? 
ATOM   961  C CB    . VAL A 1 121 ? 0.833   2.157   -19.199 1.000 50.674 0 121 VAL A CB    1 ? 
ATOM   962  C CG1   . VAL A 1 121 ? -0.210  2.811   -18.316 1.000 49.619 0 121 VAL A CG1   1 ? 
ATOM   963  C CG2   . VAL A 1 121 ? 1.268   3.103   -20.307 1.000 57.128 0 121 VAL A CG2   1 ? 
ATOM   964  N N     . PHE A 1 122 ? 3.895   3.219   -18.290 1.000 49.524 0 122 PHE A N     1 ? 
ATOM   965  C CA    . PHE A 1 122 ? 4.836   4.225   -17.729 1.000 49.654 0 122 PHE A CA    1 ? 
ATOM   966  C C     . PHE A 1 122 ? 4.622   5.579   -18.406 1.000 52.242 0 122 PHE A C     1 ? 
ATOM   967  O O     . PHE A 1 122 ? 4.530   5.623   -19.651 1.000 52.000 0 122 PHE A O     1 ? 
ATOM   968  C CB    . PHE A 1 122 ? 6.276   3.774   -17.931 1.000 48.285 0 122 PHE A CB    1 ? 
ATOM   969  C CG    . PHE A 1 122 ? 6.638   2.540   -17.156 1.000 53.876 0 122 PHE A CG    1 ? 
ATOM   970  C CD1   . PHE A 1 122 ? 7.179   2.640   -15.882 1.000 56.436 0 122 PHE A CD1   1 ? 
ATOM   971  C CD2   . PHE A 1 122 ? 6.413   1.282   -17.687 1.000 51.837 0 122 PHE A CD2   1 ? 
ATOM   972  C CE1   . PHE A 1 122 ? 7.521   1.501   -15.171 1.000 57.869 0 122 PHE A CE1   1 ? 
ATOM   973  C CE2   . PHE A 1 122 ? 6.746   0.144   -16.972 1.000 57.645 0 122 PHE A CE2   1 ? 
ATOM   974  C CZ    . PHE A 1 122 ? 7.300   0.255   -15.716 1.000 59.513 0 122 PHE A CZ    1 ? 
ATOM   975  N N     . LYS A 1 123 ? 4.559   6.644   -17.604 1.000 51.797 0 123 LYS A N     1 ? 
ATOM   976  C CA    . LYS A 1 123 ? 4.523   8.053   -18.073 1.000 53.727 0 123 LYS A CA    1 ? 
ATOM   977  C C     . LYS A 1 123 ? 5.432   8.901   -17.188 1.000 56.416 0 123 LYS A C     1 ? 
ATOM   978  O O     . LYS A 1 123 ? 5.886   8.438   -16.135 1.000 44.891 0 123 LYS A O     1 ? 
ATOM   979  C CB    . LYS A 1 123 ? 3.089   8.597   -18.074 1.000 55.385 0 123 LYS A CB    1 ? 
ATOM   980  C CG    . LYS A 1 123 ? 2.430   8.666   -19.447 1.000 57.465 0 123 LYS A CG    1 ? 
ATOM   981  C CD    . LYS A 1 123 ? 1.132   9.437   -19.467 1.000 59.081 0 123 LYS A CD    1 ? 
ATOM   982  C CE    . LYS A 1 123 ? 1.317   10.936  -19.358 1.000 62.561 0 123 LYS A CE    1 ? 
ATOM   983  N NZ    . LYS A 1 123 ? 1.794   11.526  -20.633 1.000 62.992 0 123 LYS A NZ    1 ? 
ATOM   984  N N     . PRO A 1 124 ? 5.755   10.144  -17.635 1.000 56.058 0 124 PRO A N     1 ? 
ATOM   985  C CA    . PRO A 1 124 ? 6.504   11.113  -16.832 1.000 52.099 0 124 PRO A CA    1 ? 
ATOM   986  C C     . PRO A 1 124 ? 6.024   11.269  -15.383 1.000 43.921 0 124 PRO A C     1 ? 
ATOM   987  O O     . PRO A 1 124 ? 4.994   11.889  -15.178 1.000 46.876 0 124 PRO A O     1 ? 
ATOM   988  C CB    . PRO A 1 124 ? 6.247   12.432  -17.585 1.000 57.826 0 124 PRO A CB    1 ? 
ATOM   989  C CG    . PRO A 1 124 ? 6.123   12.011  -19.031 1.000 59.716 0 124 PRO A CG    1 ? 
ATOM   990  C CD    . PRO A 1 124 ? 5.454   10.653  -18.982 1.000 55.679 0 124 PRO A CD    1 ? 
ATOM   991  N N     . GLY A 1 125 ? 6.773   10.702  -14.435 1.000 42.070 0 125 GLY A N     1 ? 
ATOM   992  C CA    . GLY A 1 125 ? 6.586   10.902  -12.980 1.000 43.047 0 125 GLY A CA    1 ? 
ATOM   993  C C     . GLY A 1 125 ? 5.612   9.902   -12.350 1.000 45.725 0 125 GLY A C     1 ? 
ATOM   994  O O     . GLY A 1 125 ? 5.382   9.998   -11.136 1.000 40.724 0 125 GLY A O     1 ? 
ATOM   995  N N     . TYR A 1 126 ? 5.051   8.955   -13.113 1.000 49.232 0 126 TYR A N     1 ? 
ATOM   996  C CA    . TYR A 1 126 ? 4.104   7.956   -12.548 1.000 47.836 0 126 TYR A CA    1 ? 
ATOM   997  C C     . TYR A 1 126 ? 3.901   6.768   -13.484 1.000 47.237 0 126 TYR A C     1 ? 
ATOM   998  O O     . TYR A 1 126 ? 4.221   6.828   -14.698 1.000 35.046 0 126 TYR A O     1 ? 
ATOM   999  C CB    . TYR A 1 126 ? 2.762   8.608   -12.209 1.000 54.076 0 126 TYR A CB    1 ? 
ATOM   1000 C CG    . TYR A 1 126 ? 1.960   9.124   -13.380 1.000 56.255 0 126 TYR A CG    1 ? 
ATOM   1001 C CD1   . TYR A 1 126 ? 2.128   10.420  -13.849 1.000 61.524 0 126 TYR A CD1   1 ? 
ATOM   1002 C CD2   . TYR A 1 126 ? 0.996   8.335   -13.989 1.000 58.840 0 126 TYR A CD2   1 ? 
ATOM   1003 C CE1   . TYR A 1 126 ? 1.381   10.909  -14.911 1.000 60.736 0 126 TYR A CE1   1 ? 
ATOM   1004 C CE2   . TYR A 1 126 ? 0.237   8.810   -15.049 1.000 58.836 0 126 TYR A CE2   1 ? 
ATOM   1005 C CZ    . TYR A 1 126 ? 0.430   10.101  -15.513 1.000 61.472 0 126 TYR A CZ    1 ? 
ATOM   1006 O OH    . TYR A 1 126 ? -0.324  10.577  -16.550 1.000 56.369 0 126 TYR A OH    1 ? 
ATOM   1007 N N     . HIS A 1 127 ? 3.360   5.695   -12.908 1.000 44.254 0 127 HIS A N     1 ? 
ATOM   1008 C CA    . HIS A 1 127 ? 2.840   4.529   -13.659 1.000 44.662 0 127 HIS A CA    1 ? 
ATOM   1009 C C     . HIS A 1 127 ? 1.372   4.312   -13.291 1.000 45.710 0 127 HIS A C     1 ? 
ATOM   1010 O O     . HIS A 1 127 ? 0.941   4.749   -12.173 1.000 36.872 0 127 HIS A O     1 ? 
ATOM   1011 C CB    . HIS A 1 127 ? 3.709   3.297   -13.405 1.000 50.285 0 127 HIS A CB    1 ? 
ATOM   1012 C CG    . HIS A 1 127 ? 3.999   3.058   -11.969 1.000 52.115 0 127 HIS A CG    1 ? 
ATOM   1013 N ND1   . HIS A 1 127 ? 5.196   3.417   -11.396 1.000 54.604 0 127 HIS A ND1   1 ? 
ATOM   1014 C CD2   . HIS A 1 127 ? 3.253   2.508   -10.988 1.000 58.660 0 127 HIS A CD2   1 ? 
ATOM   1015 C CE1   . HIS A 1 127 ? 5.185   3.094   -10.119 1.000 58.616 0 127 HIS A CE1   1 ? 
ATOM   1016 N NE2   . HIS A 1 127 ? 3.999   2.539   -9.839  1.000 55.284 0 127 HIS A NE2   1 ? 
ATOM   1017 N N     . VAL A 1 128 ? 0.622   3.719   -14.215 1.000 40.473 0 128 VAL A N     1 ? 
ATOM   1018 C CA    . VAL A 1 128 ? -0.747  3.203   -13.955 1.000 40.066 0 128 VAL A CA    1 ? 
ATOM   1019 C C     . VAL A 1 128 ? -0.683  1.681   -14.011 1.000 37.483 0 128 VAL A C     1 ? 
ATOM   1020 O O     . VAL A 1 128 ? -0.198  1.142   -15.017 1.000 36.741 0 128 VAL A O     1 ? 
ATOM   1021 C CB    . VAL A 1 128 ? -1.774  3.799   -14.927 1.000 41.507 0 128 VAL A CB    1 ? 
ATOM   1022 C CG1   . VAL A 1 128 ? -3.188  3.343   -14.599 1.000 43.137 0 128 VAL A CG1   1 ? 
ATOM   1023 C CG2   . VAL A 1 128 ? -1.692  5.317   -14.935 1.000 44.130 0 128 VAL A CG2   1 ? 
ATOM   1024 N N     . ASP A 1 129 ? -1.043  1.041   -12.902 1.000 31.290 0 129 ASP A N     1 ? 
ATOM   1025 C CA    . ASP A 1 129 ? -1.128  -0.425  -12.761 1.000 30.697 0 129 ASP A CA    1 ? 
ATOM   1026 C C     . ASP A 1 129 ? -2.581  -0.813  -13.010 1.000 31.486 0 129 ASP A C     1 ? 
ATOM   1027 O O     . ASP A 1 129 ? -3.433  -0.423  -12.183 1.000 23.669 0 129 ASP A O     1 ? 
ATOM   1028 C CB    . ASP A 1 129 ? -0.659  -0.874  -11.377 1.000 32.136 0 129 ASP A CB    1 ? 
ATOM   1029 C CG    . ASP A 1 129 ? 0.838   -0.761  -11.182 1.000 36.967 0 129 ASP A CG    1 ? 
ATOM   1030 O OD1   . ASP A 1 129 ? 1.551   -0.647  -12.206 1.000 37.000 0 129 ASP A OD1   1 ? 
ATOM   1031 O OD2   . ASP A 1 129 ? 1.284   -0.829  -10.009 1.000 36.539 0 129 ASP A OD2   1 ? 
ATOM   1032 N N     . LEU A 1 130 ? -2.853  -1.455  -14.154 1.000 31.028 0 130 LEU A N     1 ? 
ATOM   1033 C CA    . LEU A 1 130 ? -4.212  -1.911  -14.524 1.000 30.284 0 130 LEU A CA    1 ? 
ATOM   1034 C C     . LEU A 1 130 ? -4.348  -3.370  -14.137 1.000 27.405 0 130 LEU A C     1 ? 
ATOM   1035 O O     . LEU A 1 130 ? -3.740  -4.220  -14.784 1.000 24.947 0 130 LEU A O     1 ? 
ATOM   1036 C CB    . LEU A 1 130 ? -4.469  -1.735  -16.018 1.000 32.916 0 130 LEU A CB    1 ? 
ATOM   1037 C CG    . LEU A 1 130 ? -4.388  -0.296  -16.512 1.000 36.039 0 130 LEU A CG    1 ? 
ATOM   1038 C CD1   . LEU A 1 130 ? -3.064  -0.060  -17.218 1.000 40.989 0 130 LEU A CD1   1 ? 
ATOM   1039 C CD2   . LEU A 1 130 ? -5.553  0.032   -17.420 1.000 41.159 0 130 LEU A CD2   1 ? 
ATOM   1040 N N     . ALA A 1 131 ? -5.140  -3.620  -13.116 1.000 23.098 0 131 ALA A N     1 ? 
ATOM   1041 C CA    . ALA A 1 131 ? -5.642  -4.946  -12.772 1.000 20.962 0 131 ALA A CA    1 ? 
ATOM   1042 C C     . ALA A 1 131 ? -6.744  -5.282  -13.772 1.000 19.787 0 131 ALA A C     1 ? 
ATOM   1043 O O     . ALA A 1 131 ? -7.652  -4.447  -13.993 1.000 19.531 0 131 ALA A O     1 ? 
ATOM   1044 C CB    . ALA A 1 131 ? -6.122  -4.962  -11.357 1.000 21.699 0 131 ALA A CB    1 ? 
ATOM   1045 N N     . VAL A 1 132 ? -6.630  -6.449  -14.370 1.000 20.565 0 132 VAL A N     1 ? 
ATOM   1046 C CA    . VAL A 1 132 ? -7.538  -6.919  -15.444 1.000 19.415 0 132 VAL A CA    1 ? 
ATOM   1047 C C     . VAL A 1 132 ? -8.388  -8.087  -14.925 1.000 17.052 0 132 VAL A C     1 ? 
ATOM   1048 O O     . VAL A 1 132 ? -7.830  -9.099  -14.543 1.000 18.585 0 132 VAL A O     1 ? 
ATOM   1049 C CB    . VAL A 1 132 ? -6.721  -7.289  -16.692 1.000 20.719 0 132 VAL A CB    1 ? 
ATOM   1050 C CG1   . VAL A 1 132 ? -7.600  -7.838  -17.785 1.000 23.557 0 132 VAL A CG1   1 ? 
ATOM   1051 C CG2   . VAL A 1 132 ? -5.954  -6.079  -17.186 1.000 23.728 0 132 VAL A CG2   1 ? 
ATOM   1052 N N     . TYR A 1 133 ? -9.704  -7.915  -14.931 1.000 15.109 0 133 TYR A N     1 ? 
ATOM   1053 C CA    . TYR A 1 133 ? -10.665 -8.907  -14.411 1.000 17.702 0 133 TYR A CA    1 ? 
ATOM   1054 C C     . TYR A 1 133 ? -11.627 -9.348  -15.507 1.000 19.608 0 133 TYR A C     1 ? 
ATOM   1055 O O     . TYR A 1 133 ? -11.927 -8.566  -16.397 1.000 22.894 0 133 TYR A O     1 ? 
ATOM   1056 C CB    . TYR A 1 133 ? -11.456 -8.330  -13.235 1.000 17.095 0 133 TYR A CB    1 ? 
ATOM   1057 C CG    . TYR A 1 133 ? -10.598 -7.773  -12.124 1.000 16.212 0 133 TYR A CG    1 ? 
ATOM   1058 C CD1   . TYR A 1 133 ? -10.139 -6.467  -12.176 1.000 17.520 0 133 TYR A CD1   1 ? 
ATOM   1059 C CD2   . TYR A 1 133 ? -10.273 -8.521  -11.014 1.000 16.522 0 133 TYR A CD2   1 ? 
ATOM   1060 C CE1   . TYR A 1 133 ? -9.383  -5.910  -11.149 1.000 16.483 0 133 TYR A CE1   1 ? 
ATOM   1061 C CE2   . TYR A 1 133 ? -9.482  -8.000  -9.999  1.000 15.933 0 133 TYR A CE2   1 ? 
ATOM   1062 C CZ    . TYR A 1 133 ? -9.036  -6.683  -10.063 1.000 16.346 0 133 TYR A CZ    1 ? 
ATOM   1063 O OH    . TYR A 1 133 ? -8.261  -6.138  -9.056  1.000 17.132 0 133 TYR A OH    1 ? 
ATOM   1064 N N     . ALA A 1 134 ? -12.161 -10.552 -15.355 1.000 22.677 0 134 ALA A N     1 ? 
ATOM   1065 C CA    . ALA A 1 134 ? -13.264 -11.094 -16.182 1.000 22.162 0 134 ALA A CA    1 ? 
ATOM   1066 C C     . ALA A 1 134 ? -14.584 -10.740 -15.512 1.000 23.120 0 134 ALA A C     1 ? 
ATOM   1067 O O     . ALA A 1 134 ? -14.577 -10.419 -14.315 1.000 19.786 0 134 ALA A O     1 ? 
ATOM   1068 C CB    . ALA A 1 134 ? -13.093 -12.578 -16.340 1.000 22.187 0 134 ALA A CB    1 ? 
ATOM   1069 N N     . ASP A 1 135 ? -15.671 -10.762 -16.270 1.000 23.472 0 135 ASP A N     1 ? 
ATOM   1070 C CA    . ASP A 1 135 ? -17.009 -10.356 -15.786 1.000 23.175 0 135 ASP A CA    1 ? 
ATOM   1071 C C     . ASP A 1 135 ? -17.536 -11.451 -14.878 1.000 23.708 0 135 ASP A C     1 ? 
ATOM   1072 O O     . ASP A 1 135 ? -17.699 -12.598 -15.304 1.000 24.814 0 135 ASP A O     1 ? 
ATOM   1073 C CB    . ASP A 1 135 ? -17.921 -10.077 -16.970 1.000 26.661 0 135 ASP A CB    1 ? 
ATOM   1074 C CG    . ASP A 1 135 ? -19.238 -9.401  -16.649 1.000 27.886 0 135 ASP A CG    1 ? 
ATOM   1075 O OD1   . ASP A 1 135 ? -19.684 -9.485  -15.493 1.000 31.421 0 135 ASP A OD1   1 ? 
ATOM   1076 O OD2   . ASP A 1 135 ? -19.834 -8.835  -17.601 1.000 35.230 0 135 ASP A OD2   1 ? 
ATOM   1077 N N     . PRO A 1 136 ? -17.819 -11.146 -13.598 1.000 21.148 0 136 PRO A N     1 ? 
ATOM   1078 C CA    . PRO A 1 136 ? -18.414 -12.137 -12.719 1.000 23.829 0 136 PRO A CA    1 ? 
ATOM   1079 C C     . PRO A 1 136 ? -19.680 -12.768 -13.341 1.000 26.717 0 136 PRO A C     1 ? 
ATOM   1080 O O     . PRO A 1 136 ? -19.839 -13.967 -13.207 1.000 28.402 0 136 PRO A O     1 ? 
ATOM   1081 C CB    . PRO A 1 136 ? -18.728 -11.357 -11.430 1.000 23.079 0 136 PRO A CB    1 ? 
ATOM   1082 C CG    . PRO A 1 136 ? -17.763 -10.153 -11.462 1.000 22.301 0 136 PRO A CG    1 ? 
ATOM   1083 C CD    . PRO A 1 136 ? -17.565 -9.854  -12.935 1.000 23.045 0 136 PRO A CD    1 ? 
ATOM   1084 N N     . GLU A 1 137 ? -20.517 -11.960 -14.006 1.000 29.460 0 137 GLU A N     1 ? 
ATOM   1085 C CA    . GLU A 1 137 ? -21.860 -12.359 -14.534 1.000 34.898 0 137 GLU A CA    1 ? 
ATOM   1086 C C     . GLU A 1 137 ? -21.686 -13.410 -15.629 1.000 33.109 0 137 GLU A C     1 ? 
ATOM   1087 O O     . GLU A 1 137 ? -22.650 -14.105 -15.922 1.000 35.023 0 137 GLU A O     1 ? 
ATOM   1088 C CB    . GLU A 1 137 ? -22.616 -11.162 -15.119 1.000 40.516 0 137 GLU A CB    1 ? 
ATOM   1089 C CG    . GLU A 1 137 ? -23.335 -10.323 -14.073 1.000 48.821 0 137 GLU A CG    1 ? 
ATOM   1090 C CD    . GLU A 1 137 ? -22.453 -9.802  -12.950 1.000 58.859 0 137 GLU A CD    1 ? 
ATOM   1091 O OE1   . GLU A 1 137 ? -21.312 -9.346  -13.242 1.000 60.954 0 137 GLU A OE1   1 ? 
ATOM   1092 O OE2   . GLU A 1 137 ? -22.894 -9.865  -11.780 1.000 70.875 0 137 GLU A OE2   1 ? 
ATOM   1093 N N     . LEU A 1 138 ? -20.502 -13.455 -16.237 1.000 31.156 0 138 LEU A N     1 ? 
ATOM   1094 C CA    . LEU A 1 138 ? -20.157 -14.348 -17.366 1.000 28.948 0 138 LEU A CA    1 ? 
ATOM   1095 C C     . LEU A 1 138 ? -19.194 -15.420 -16.897 1.000 29.617 0 138 LEU A C     1 ? 
ATOM   1096 O O     . LEU A 1 138 ? -18.866 -16.262 -17.738 1.000 27.817 0 138 LEU A O     1 ? 
ATOM   1097 C CB    . LEU A 1 138 ? -19.489 -13.537 -18.471 1.000 28.483 0 138 LEU A CB    1 ? 
ATOM   1098 C CG    . LEU A 1 138 ? -20.359 -12.485 -19.141 1.000 31.248 0 138 LEU A CG    1 ? 
ATOM   1099 C CD1   . LEU A 1 138 ? -19.581 -11.750 -20.210 1.000 30.184 0 138 LEU A CD1   1 ? 
ATOM   1100 C CD2   . LEU A 1 138 ? -21.617 -13.118 -19.723 1.000 34.452 0 138 LEU A CD2   1 ? 
ATOM   1101 N N     . SER A 1 139 ? -18.731 -15.364 -15.635 1.000 24.706 0 139 SER A N     1 ? 
ATOM   1102 C CA    . SER A 1 139 ? -17.604 -16.206 -15.138 1.000 27.649 0 139 SER A CA    1 ? 
ATOM   1103 C C     . SER A 1 139 ? -18.023 -17.018 -13.913 1.000 29.283 0 139 SER A C     1 ? 
ATOM   1104 O O     . SER A 1 139 ? -17.129 -17.477 -13.186 1.000 34.122 0 139 SER A O     1 ? 
ATOM   1105 C CB    . SER A 1 139 ? -16.363 -15.380 -14.865 1.000 25.545 0 139 SER A CB    1 ? 
ATOM   1106 O OG    . SER A 1 139 ? -16.008 -14.625 -16.015 1.000 23.046 0 139 SER A OG    1 ? 
ATOM   1107 N N     . GLY A 1 140 ? -19.325 -17.249 -13.734 1.000 31.950 0 140 GLY A N     1 ? 
ATOM   1108 C CA    . GLY A 1 140 ? -19.854 -18.110 -12.654 1.000 32.419 0 140 GLY A CA    1 ? 
ATOM   1109 C C     . GLY A 1 140 ? -19.936 -17.385 -11.316 1.000 33.247 0 140 GLY A C     1 ? 
ATOM   1110 O O     . GLY A 1 140 ? -19.977 -18.071 -10.269 1.000 31.101 0 140 GLY A O     1 ? 
ATOM   1111 N N     . GLY A 1 141 ? -20.017 -16.049 -11.340 1.000 34.155 0 141 GLY A N     1 ? 
ATOM   1112 C CA    . GLY A 1 141 ? -20.257 -15.215 -10.143 1.000 32.952 0 141 GLY A CA    1 ? 
ATOM   1113 C C     . GLY A 1 141 ? -18.995 -14.940 -9.325  1.000 30.918 0 141 GLY A C     1 ? 
ATOM   1114 O O     . GLY A 1 141 ? -19.134 -14.383 -8.248  1.000 29.517 0 141 GLY A O     1 ? 
ATOM   1115 N N     . THR A 1 142 ? -17.797 -15.292 -9.810  1.000 29.790 0 142 THR A N     1 ? 
ATOM   1116 C CA    . THR A 1 142 ? -16.508 -14.961 -9.131  1.000 30.782 0 142 THR A CA    1 ? 
ATOM   1117 C C     . THR A 1 142 ? -15.832 -13.804 -9.894  1.000 26.719 0 142 THR A C     1 ? 
ATOM   1118 O O     . THR A 1 142 ? -15.904 -13.784 -11.140 1.000 24.629 0 142 THR A O     1 ? 
ATOM   1119 C CB    . THR A 1 142 ? -15.648 -16.218 -8.922  1.000 33.988 0 142 THR A CB    1 ? 
ATOM   1120 O OG1   . THR A 1 142 ? -14.784 -16.425 -10.040 1.000 39.879 0 142 THR A OG1   1 ? 
ATOM   1121 C CG2   . THR A 1 142 ? -16.496 -17.459 -8.696  1.000 35.110 0 142 THR A CG2   1 ? 
ATOM   1122 N N     . LEU A 1 143 ? -15.286 -12.826 -9.170  1.000 22.941 0 143 LEU A N     1 ? 
ATOM   1123 C CA    . LEU A 1 143 ? -14.382 -11.795 -9.742  1.000 20.888 0 143 LEU A CA    1 ? 
ATOM   1124 C C     . LEU A 1 143 ? -12.956 -12.344 -9.749  1.000 21.139 0 143 LEU A C     1 ? 
ATOM   1125 O O     . LEU A 1 143 ? -12.369 -12.542 -8.667  1.000 21.419 0 143 LEU A O     1 ? 
ATOM   1126 C CB    . LEU A 1 143 ? -14.475 -10.503 -8.933  1.000 22.844 0 143 LEU A CB    1 ? 
ATOM   1127 C CG    . LEU A 1 143 ? -13.695 -9.308  -9.492  1.000 22.178 0 143 LEU A CG    1 ? 
ATOM   1128 C CD1   . LEU A 1 143 ? -14.272 -8.847  -10.811 1.000 21.335 0 143 LEU A CD1   1 ? 
ATOM   1129 C CD2   . LEU A 1 143 ? -13.672 -8.143  -8.481  1.000 22.727 0 143 LEU A CD2   1 ? 
ATOM   1130 N N     . CYS A 1 144 ? -12.398 -12.537 -10.933 1.000 18.838 0 144 CYS A N     1 ? 
ATOM   1131 C CA    . CYS A 1 144 ? -11.063 -13.139 -11.109 1.000 20.194 0 144 CYS A CA    1 ? 
ATOM   1132 C C     . CYS A 1 144 ? -10.152 -12.175 -11.852 1.000 18.352 0 144 CYS A C     1 ? 
ATOM   1133 O O     . CYS A 1 144 ? -10.550 -11.650 -12.920 1.000 17.780 0 144 CYS A O     1 ? 
ATOM   1134 C CB    . CYS A 1 144 ? -11.158 -14.466 -11.849 1.000 21.135 0 144 CYS A CB    1 ? 
ATOM   1135 S SG    . CYS A 1 144 ? -12.049 -15.718 -10.910 1.000 24.962 0 144 CYS A SG    1 ? 
ATOM   1136 N N     . ILE A 1 145 ? -8.950  -12.027 -11.308 1.000 17.486 0 145 ILE A N     1 ? 
ATOM   1137 C CA    . ILE A 1 145 ? -7.834  -11.216 -11.830 1.000 16.755 0 145 ILE A CA    1 ? 
ATOM   1138 C C     . ILE A 1 145 ? -6.981  -12.132 -12.736 1.000 17.703 0 145 ILE A C     1 ? 
ATOM   1139 O O     . ILE A 1 145 ? -6.819  -13.350 -12.412 1.000 19.424 0 145 ILE A O     1 ? 
ATOM   1140 C CB    . ILE A 1 145 ? -7.038  -10.564 -10.669 1.000 16.780 0 145 ILE A CB    1 ? 
ATOM   1141 C CG1   . ILE A 1 145 ? -6.095  -9.460  -11.155 1.000 18.107 0 145 ILE A CG1   1 ? 
ATOM   1142 C CG2   . ILE A 1 145 ? -6.303  -11.593 -9.823  1.000 18.184 0 145 ILE A CG2   1 ? 
ATOM   1143 C CD1   . ILE A 1 145 ? -5.578  -8.544  -10.068 1.000 18.751 0 145 ILE A CD1   1 ? 
ATOM   1144 N N     . ALA A 1 146 ? -6.471  -11.571 -13.811 1.000 18.408 0 146 ALA A N     1 ? 
ATOM   1145 C CA    . ALA A 1 146 ? -5.625  -12.256 -14.820 1.000 22.993 0 146 ALA A CA    1 ? 
ATOM   1146 C C     . ALA A 1 146 ? -4.179  -12.330 -14.310 1.000 24.119 0 146 ALA A C     1 ? 
ATOM   1147 O O     . ALA A 1 146 ? -3.504  -11.304 -14.372 1.000 23.985 0 146 ALA A O     1 ? 
ATOM   1148 C CB    . ALA A 1 146 ? -5.717  -11.499 -16.125 1.000 24.286 0 146 ALA A CB    1 ? 
ATOM   1149 N N     . LYS A 1 147 ? -3.749  -13.498 -13.807 1.000 26.032 0 147 LYS A N     1 ? 
ATOM   1150 C CA    . LYS A 1 147 ? -2.398  -13.738 -13.221 1.000 28.850 0 147 LYS A CA    1 ? 
ATOM   1151 C C     . LYS A 1 147 ? -1.539  -14.571 -14.184 1.000 31.013 0 147 LYS A C     1 ? 
ATOM   1152 O O     . LYS A 1 147 ? -2.078  -15.483 -14.818 1.000 26.327 0 147 LYS A O     1 ? 
ATOM   1153 C CB    . LYS A 1 147 ? -2.467  -14.496 -11.891 1.000 32.443 0 147 LYS A CB    1 ? 
ATOM   1154 C CG    . LYS A 1 147 ? -3.068  -13.728 -10.724 1.000 36.098 0 147 LYS A CG    1 ? 
ATOM   1155 C CD    . LYS A 1 147 ? -2.210  -12.574 -10.218 1.000 42.575 0 147 LYS A CD    1 ? 
ATOM   1156 C CE    . LYS A 1 147 ? -1.709  -12.767 -8.797  1.000 49.169 0 147 LYS A CE    1 ? 
ATOM   1157 N NZ    . LYS A 1 147 ? -0.745  -13.890 -8.709  1.000 52.871 0 147 LYS A NZ    1 ? 
ATOM   1158 N N     . GLY A 1 148 ? -0.237  -14.269 -14.240 1.000 32.688 0 148 GLY A N     1 ? 
ATOM   1159 C CA    . GLY A 1 148 ? 0.753   -14.942 -15.104 1.000 34.638 0 148 GLY A CA    1 ? 
ATOM   1160 C C     . GLY A 1 148 ? 1.351   -13.988 -16.132 1.000 35.322 0 148 GLY A C     1 ? 
ATOM   1161 O O     . GLY A 1 148 ? 0.703   -12.975 -16.459 1.000 24.644 0 148 GLY A O     1 ? 
ATOM   1162 N N     . LYS A 1 149 ? 2.566   -14.309 -16.592 1.000 38.169 0 149 LYS A N     1 ? 
ATOM   1163 C CA    . LYS A 1 149 ? 3.299   -13.625 -17.684 1.000 41.064 0 149 LYS A CA    1 ? 
ATOM   1164 C C     . LYS A 1 149 ? 3.492   -14.639 -18.798 1.000 38.634 0 149 LYS A C     1 ? 
ATOM   1165 O O     . LYS A 1 149 ? 3.149   -15.810 -18.571 1.000 36.169 0 149 LYS A O     1 ? 
ATOM   1166 C CB    . LYS A 1 149 ? 4.680   -13.142 -17.224 1.000 43.156 0 149 LYS A CB    1 ? 
ATOM   1167 C CG    . LYS A 1 149 ? 4.695   -12.170 -16.053 1.000 45.818 0 149 LYS A CG    1 ? 
ATOM   1168 C CD    . LYS A 1 149 ? 5.923   -11.253 -16.042 1.000 46.339 0 149 LYS A CD    1 ? 
ATOM   1169 C CE    . LYS A 1 149 ? 6.534   -11.060 -14.665 1.000 47.021 0 149 LYS A CE    1 ? 
ATOM   1170 N NZ    . LYS A 1 149 ? 7.032   -12.339 -14.107 1.000 45.711 0 149 LYS A NZ    1 ? 
ATOM   1171 N N     . GLU A 1 150 ? 4.122   -14.233 -19.898 1.000 45.500 0 150 GLU A N     1 ? 
ATOM   1172 C CA    . GLU A 1 150 ? 4.560   -15.165 -20.970 1.000 52.766 0 150 GLU A CA    1 ? 
ATOM   1173 C C     . GLU A 1 150 ? 5.499   -16.208 -20.351 1.000 54.615 0 150 GLU A C     1 ? 
ATOM   1174 O O     . GLU A 1 150 ? 5.416   -17.370 -20.761 1.000 60.998 0 150 GLU A O     1 ? 
ATOM   1175 C CB    . GLU A 1 150 ? 5.218   -14.405 -22.120 1.000 54.696 0 150 GLU A CB    1 ? 
ATOM   1176 C CG    . GLU A 1 150 ? 4.295   -13.394 -22.784 1.000 57.444 0 150 GLU A CG    1 ? 
ATOM   1177 C CD    . GLU A 1 150 ? 4.276   -12.025 -22.117 1.000 61.624 0 150 GLU A CD    1 ? 
ATOM   1178 O OE1   . GLU A 1 150 ? 4.248   -11.014 -22.854 1.000 61.822 0 150 GLU A OE1   1 ? 
ATOM   1179 O OE2   . GLU A 1 150 ? 4.299   -11.973 -20.855 1.000 52.202 0 150 GLU A OE2   1 ? 
ATOM   1180 N N     . ASN A 1 151 ? 6.294   -15.806 -19.353 1.000 60.672 0 151 ASN A N     1 ? 
ATOM   1181 C CA    . ASN A 1 151 ? 7.234   -16.671 -18.581 1.000 66.013 0 151 ASN A CA    1 ? 
ATOM   1182 C C     . ASN A 1 151 ? 6.523   -17.344 -17.400 1.000 65.589 0 151 ASN A C     1 ? 
ATOM   1183 O O     . ASN A 1 151 ? 6.890   -17.029 -16.253 1.000 76.246 0 151 ASN A O     1 ? 
ATOM   1184 C CB    . ASN A 1 151 ? 8.398   -15.864 -17.996 1.000 67.399 0 151 ASN A CB    1 ? 
ATOM   1185 C CG    . ASN A 1 151 ? 9.413   -15.436 -19.028 1.000 72.332 0 151 ASN A CG    1 ? 
ATOM   1186 O OD1   . ASN A 1 151 ? 9.173   -15.558 -20.229 1.000 77.957 0 151 ASN A OD1   1 ? 
ATOM   1187 N ND2   . ASN A 1 151 ? 10.553  -14.940 -18.568 1.000 66.268 0 151 ASN A ND2   1 ? 
ATOM   1188 N N     . SER A 1 152 ? 5.571   -18.245 -17.654 1.000 62.143 0 152 SER A N     1 ? 
ATOM   1189 C CA    . SER A 1 152 ? 4.838   -19.005 -16.602 1.000 60.886 0 152 SER A CA    1 ? 
ATOM   1190 C C     . SER A 1 152 ? 4.487   -20.399 -17.128 1.000 56.701 0 152 SER A C     1 ? 
ATOM   1191 O O     . SER A 1 152 ? 3.621   -20.454 -18.018 1.000 57.794 0 152 SER A O     1 ? 
ATOM   1192 C CB    . SER A 1 152 ? 3.581   -18.269 -16.140 1.000 60.359 0 152 SER A CB    1 ? 
ATOM   1193 O OG    . SER A 1 152 ? 3.871   -16.957 -15.669 1.000 52.112 0 152 SER A OG    1 ? 
ATOM   1194 N N     . ARG A 1 157 ? -0.206  -19.487 -14.657 1.000 51.156 0 157 ARG A N     1 ? 
ATOM   1195 C CA    . ARG A 1 157 ? -0.974  -18.355 -15.244 1.000 51.101 0 157 ARG A CA    1 ? 
ATOM   1196 C C     . ARG A 1 157 ? -2.474  -18.679 -15.210 1.000 46.061 0 157 ARG A C     1 ? 
ATOM   1197 O O     . ARG A 1 157 ? -2.940  -19.405 -16.101 1.000 50.847 0 157 ARG A O     1 ? 
ATOM   1198 C CB    . ARG A 1 157 ? -0.511  -18.065 -16.677 1.000 56.202 0 157 ARG A CB    1 ? 
ATOM   1199 C CG    . ARG A 1 157 ? -0.529  -19.265 -17.616 1.000 58.901 0 157 ARG A CG    1 ? 
ATOM   1200 C CD    . ARG A 1 157 ? -0.783  -18.878 -19.069 1.000 58.497 0 157 ARG A CD    1 ? 
ATOM   1201 N NE    . ARG A 1 157 ? 0.412   -18.352 -19.717 1.000 58.797 0 157 ARG A NE    1 ? 
ATOM   1202 C CZ    . ARG A 1 157 ? 0.501   -17.980 -20.997 1.000 58.613 0 157 ARG A CZ    1 ? 
ATOM   1203 N NH1   . ARG A 1 157 ? -0.546  -18.059 -21.805 1.000 55.173 0 157 ARG A NH1   1 ? 
ATOM   1204 N NH2   . ARG A 1 157 ? 1.649   -17.517 -21.460 1.000 63.465 0 157 ARG A NH2   1 ? 
ATOM   1205 N N     . LEU A 1 158 ? -3.212  -18.159 -14.227 1.000 35.485 0 158 LEU A N     1 ? 
ATOM   1206 C CA    . LEU A 1 158 ? -4.647  -18.490 -14.068 1.000 37.173 0 158 LEU A CA    1 ? 
ATOM   1207 C C     . LEU A 1 158 ? -5.485  -17.226 -13.821 1.000 31.136 0 158 LEU A C     1 ? 
ATOM   1208 O O     . LEU A 1 158 ? -4.935  -16.091 -13.797 1.000 30.302 0 158 LEU A O     1 ? 
ATOM   1209 C CB    . LEU A 1 158 ? -4.823  -19.534 -12.953 1.000 42.940 0 158 LEU A CB    1 ? 
ATOM   1210 C CG    . LEU A 1 158 ? -4.193  -20.909 -13.220 1.000 53.093 0 158 LEU A CG    1 ? 
ATOM   1211 C CD1   . LEU A 1 158 ? -4.191  -21.778 -11.966 1.000 54.005 0 158 LEU A CD1   1 ? 
ATOM   1212 C CD2   . LEU A 1 158 ? -4.906  -21.645 -14.361 1.000 57.241 0 158 LEU A CD2   1 ? 
ATOM   1213 N N     . TRP A 1 159 ? -6.790  -17.428 -13.834 1.000 25.698 0 159 TRP A N     1 ? 
ATOM   1214 C CA    . TRP A 1 159 ? -7.817  -16.487 -13.335 1.000 25.475 0 159 TRP A CA    1 ? 
ATOM   1215 C C     . TRP A 1 159 ? -7.962  -16.698 -11.827 1.000 25.144 0 159 TRP A C     1 ? 
ATOM   1216 O O     . TRP A 1 159 ? -8.492  -17.741 -11.426 1.000 29.596 0 159 TRP A O     1 ? 
ATOM   1217 C CB    . TRP A 1 159 ? -9.122  -16.696 -14.088 1.000 21.989 0 159 TRP A CB    1 ? 
ATOM   1218 C CG    . TRP A 1 159 ? -9.047  -16.253 -15.508 1.000 24.439 0 159 TRP A CG    1 ? 
ATOM   1219 C CD1   . TRP A 1 159 ? -8.931  -17.048 -16.612 1.000 25.758 0 159 TRP A CD1   1 ? 
ATOM   1220 C CD2   . TRP A 1 159 ? -9.101  -14.897 -15.995 1.000 24.142 0 159 TRP A CD2   1 ? 
ATOM   1221 N NE1   . TRP A 1 159 ? -8.889  -16.284 -17.746 1.000 23.760 0 159 TRP A NE1   1 ? 
ATOM   1222 C CE2   . TRP A 1 159 ? -9.008  -14.964 -17.404 1.000 24.385 0 159 TRP A CE2   1 ? 
ATOM   1223 C CE3   . TRP A 1 159 ? -9.216  -13.640 -15.383 1.000 23.614 0 159 TRP A CE3   1 ? 
ATOM   1224 C CZ2   . TRP A 1 159 ? -9.038  -13.826 -18.206 1.000 25.212 0 159 TRP A CZ2   1 ? 
ATOM   1225 C CZ3   . TRP A 1 159 ? -9.247  -12.520 -16.169 1.000 21.981 0 159 TRP A CZ3   1 ? 
ATOM   1226 C CH2   . TRP A 1 159 ? -9.166  -12.615 -17.568 1.000 26.288 0 159 TRP A CH2   1 ? 
ATOM   1227 N N     . GLN A 1 160 ? -7.412  -15.796 -11.027 1.000 24.727 0 160 GLN A N     1 ? 
ATOM   1228 C CA    . GLN A 1 160 ? -7.417  -15.970 -9.554  1.000 22.732 0 160 GLN A CA    1 ? 
ATOM   1229 C C     . GLN A 1 160 ? -8.564  -15.185 -8.953  1.000 20.685 0 160 GLN A C     1 ? 
ATOM   1230 O O     . GLN A 1 160 ? -8.639  -13.968 -9.224  1.000 20.371 0 160 GLN A O     1 ? 
ATOM   1231 C CB    . GLN A 1 160 ? -6.098  -15.527 -8.943  1.000 26.052 0 160 GLN A CB    1 ? 
ATOM   1232 C CG    . GLN A 1 160 ? -5.953  -15.943 -7.484  1.000 27.532 0 160 GLN A CG    1 ? 
ATOM   1233 C CD    . GLN A 1 160 ? -4.684  -15.450 -6.842  1.000 29.038 0 160 GLN A CD    1 ? 
ATOM   1234 O OE1   . GLN A 1 160 ? -4.283  -14.294 -6.987  1.000 29.801 0 160 GLN A OE1   1 ? 
ATOM   1235 N NE2   . GLN A 1 160 ? -4.067  -16.324 -6.066  1.000 34.598 0 160 GLN A NE2   1 ? 
ATOM   1236 N N     . ILE A 1 161 ? -9.301  -15.813 -8.040  1.000 21.836 0 161 ILE A N     1 ? 
ATOM   1237 C CA    . ILE A 1 161 ? -10.360 -15.143 -7.237  1.000 22.749 0 161 ILE A CA    1 ? 
ATOM   1238 C C     . ILE A 1 161 ? -9.696  -13.923 -6.604  1.000 20.859 0 161 ILE A C     1 ? 
ATOM   1239 O O     . ILE A 1 161 ? -8.596  -14.065 -6.052  1.000 17.055 0 161 ILE A O     1 ? 
ATOM   1240 C CB    . ILE A 1 161 ? -10.981 -16.051 -6.151  1.000 28.052 0 161 ILE A CB    1 ? 
ATOM   1241 C CG1   . ILE A 1 161 ? -11.311 -17.455 -6.670  1.000 37.799 0 161 ILE A CG1   1 ? 
ATOM   1242 C CG2   . ILE A 1 161 ? -12.213 -15.378 -5.547  1.000 27.201 0 161 ILE A CG2   1 ? 
ATOM   1243 C CD1   . ILE A 1 161 ? -12.218 -18.267 -5.753  1.000 41.259 0 161 ILE A CD1   1 ? 
ATOM   1244 N N     . SER A 1 162 ? -10.401 -12.803 -6.601  1.000 20.820 0 162 SER A N     1 ? 
ATOM   1245 C CA    . SER A 1 162 ? -9.882  -11.488 -6.158  1.000 19.016 0 162 SER A CA    1 ? 
ATOM   1246 C C     . SER A 1 162 ? -11.022 -10.708 -5.516  1.000 18.805 0 162 SER A C     1 ? 
ATOM   1247 O O     . SER A 1 162 ? -12.210 -10.962 -5.903  1.000 15.285 0 162 SER A O     1 ? 
ATOM   1248 C CB    . SER A 1 162 ? -9.312  -10.743 -7.349  1.000 21.200 0 162 SER A CB    1 ? 
ATOM   1249 O OG    . SER A 1 162 ? -8.418  -9.729  -6.933  1.000 25.882 0 162 SER A OG    1 ? 
ATOM   1250 N N     . ASP A 1 163 ? -10.693 -9.769  -4.619  1.000 16.139 0 163 ASP A N     1 ? 
ATOM   1251 C CA    . ASP A 1 163 ? -11.725 -9.019  -3.878  1.000 15.652 0 163 ASP A CA    1 ? 
ATOM   1252 C C     . ASP A 1 163 ? -11.157 -7.668  -3.484  1.000 14.627 0 163 ASP A C     1 ? 
ATOM   1253 O O     . ASP A 1 163 ? -11.126 -7.330  -2.294  1.000 13.953 0 163 ASP A O     1 ? 
ATOM   1254 C CB    . ASP A 1 163 ? -12.228 -9.789  -2.658  1.000 16.434 0 163 ASP A CB    1 ? 
ATOM   1255 C CG    . ASP A 1 163 ? -13.489 -9.178  -2.078  1.000 16.580 0 163 ASP A CG    1 ? 
ATOM   1256 O OD1   . ASP A 1 163 ? -14.101 -8.320  -2.774  1.000 15.254 0 163 ASP A OD1   1 ? 
ATOM   1257 O OD2   . ASP A 1 163 ? -13.869 -9.587  -0.964  1.000 16.970 0 163 ASP A OD2   1 ? 
ATOM   1258 N N     . PRO A 1 164 ? -10.710 -6.870  -4.466  1.000 14.631 0 164 PRO A N     1 ? 
ATOM   1259 C CA    . PRO A 1 164 ? -10.153 -5.550  -4.184  1.000 15.606 0 164 PRO A CA    1 ? 
ATOM   1260 C C     . PRO A 1 164 ? -11.149 -4.622  -3.474  1.000 14.599 0 164 PRO A C     1 ? 
ATOM   1261 O O     . PRO A 1 164 ? -10.744 -3.889  -2.579  1.000 12.778 0 164 PRO A O     1 ? 
ATOM   1262 C CB    . PRO A 1 164 ? -9.810  -4.971  -5.552  1.000 15.390 0 164 PRO A CB    1 ? 
ATOM   1263 C CG    . PRO A 1 164 ? -10.716 -5.732  -6.518  1.000 16.157 0 164 PRO A CG    1 ? 
ATOM   1264 C CD    . PRO A 1 164 ? -10.870 -7.108  -5.912  1.000 16.549 0 164 PRO A CD    1 ? 
ATOM   1265 N N     . GLN A 1 165 ? -12.411 -4.645  -3.881  1.000 14.386 0 165 GLN A N     1 ? 
ATOM   1266 C CA    . GLN A 1 165 ? -13.445 -3.746  -3.293  1.000 14.781 0 165 GLN A CA    1 ? 
ATOM   1267 C C     . GLN A 1 165 ? -13.761 -4.206  -1.864  1.000 12.640 0 165 GLN A C     1 ? 
ATOM   1268 O O     . GLN A 1 165 ? -13.957 -3.323  -1.048  1.000 12.120 0 165 GLN A O     1 ? 
ATOM   1269 C CB    . GLN A 1 165 ? -14.656 -3.604  -4.233  1.000 18.271 0 165 GLN A CB    1 ? 
ATOM   1270 C CG    . GLN A 1 165 ? -14.293 -2.822  -5.503  1.000 20.739 0 165 GLN A CG    1 ? 
ATOM   1271 C CD    . GLN A 1 165 ? -15.470 -2.262  -6.271  1.000 25.837 0 165 GLN A CD    1 ? 
ATOM   1272 O OE1   . GLN A 1 165 ? -15.542 -1.060  -6.569  1.000 29.936 0 165 GLN A OE1   1 ? 
ATOM   1273 N NE2   . GLN A 1 165 ? -16.408 -3.120  -6.591  1.000 27.822 0 165 GLN A NE2   1 ? 
ATOM   1274 N N     . GLY A 1 166 ? -13.750 -5.520  -1.568  1.000 11.734 0 166 GLY A N     1 ? 
ATOM   1275 C CA    . GLY A 1 166 ? -13.873 -6.066  -0.200  1.000 11.336 0 166 GLY A CA    1 ? 
ATOM   1276 C C     . GLY A 1 166 ? -12.699 -5.629  0.667   1.000 10.885 0 166 GLY A C     1 ? 
ATOM   1277 O O     . GLY A 1 166 ? -12.894 -5.274  1.846   1.000 10.926 0 166 GLY A O     1 ? 
ATOM   1278 N N     . PHE A 1 167 ? -11.478 -5.684  0.133   1.000 11.206 0 167 PHE A N     1 ? 
ATOM   1279 C CA    . PHE A 1 167 ? -10.292 -5.208  0.884   1.000 12.126 0 167 PHE A CA    1 ? 
ATOM   1280 C C     . PHE A 1 167 ? -10.464 -3.710  1.189   1.000 11.871 0 167 PHE A C     1 ? 
ATOM   1281 O O     . PHE A 1 167 ? -10.287 -3.297  2.336   1.000 11.231 0 167 PHE A O     1 ? 
ATOM   1282 C CB    . PHE A 1 167 ? -9.001  -5.498  0.136   1.000 13.775 0 167 PHE A CB    1 ? 
ATOM   1283 C CG    . PHE A 1 167 ? -7.791  -5.069  0.908   1.000 14.761 0 167 PHE A CG    1 ? 
ATOM   1284 C CD1   . PHE A 1 167 ? -7.503  -5.638  2.142   1.000 15.566 0 167 PHE A CD1   1 ? 
ATOM   1285 C CD2   . PHE A 1 167 ? -6.945  -4.100  0.412   1.000 17.150 0 167 PHE A CD2   1 ? 
ATOM   1286 C CE1   . PHE A 1 167 ? -6.397  -5.240  2.862   1.000 16.741 0 167 PHE A CE1   1 ? 
ATOM   1287 C CE2   . PHE A 1 167 ? -5.815  -3.723  1.127   1.000 17.519 0 167 PHE A CE2   1 ? 
ATOM   1288 C CZ    . PHE A 1 167 ? -5.557  -4.278  2.351   1.000 18.602 0 167 PHE A CZ    1 ? 
ATOM   1289 N N     . GLN A 1 168 ? -10.797 -2.925  0.177   1.000 11.364 0 168 GLN A N     1 ? 
ATOM   1290 C CA    . GLN A 1 168 ? -11.062 -1.474  0.307   1.000 13.636 0 168 GLN A CA    1 ? 
ATOM   1291 C C     . GLN A 1 168 ? -12.141 -1.223  1.379   1.000 12.443 0 168 GLN A C     1 ? 
ATOM   1292 O O     . GLN A 1 168 ? -11.924 -0.346  2.257   1.000 10.401 0 168 GLN A O     1 ? 
ATOM   1293 C CB    . GLN A 1 168 ? -11.464 -0.878  -1.041  1.000 15.215 0 168 GLN A CB    1 ? 
ATOM   1294 C CG    . GLN A 1 168 ? -11.824 0.603   -0.942  1.000 20.389 0 168 GLN A CG    1 ? 
ATOM   1295 C CD    . GLN A 1 168 ? -12.415 1.205   -2.197  1.000 21.609 0 168 GLN A CD    1 ? 
ATOM   1296 O OE1   . GLN A 1 168 ? -12.845 2.369   -2.201  1.000 27.850 0 168 GLN A OE1   1 ? 
ATOM   1297 N NE2   . GLN A 1 168 ? -12.431 0.426   -3.264  1.000 20.359 0 168 GLN A NE2   1 ? 
ATOM   1298 N N     . ASP A 1 169 ? -13.252 -1.973  1.336   1.000 12.544 0 169 ASP A N     1 ? 
ATOM   1299 C CA    . ASP A 1 169 ? -14.317 -1.876  2.364   1.000 13.913 0 169 ASP A CA    1 ? 
ATOM   1300 C C     . ASP A 1 169 ? -13.735 -2.178  3.758   1.000 12.853 0 169 ASP A C     1 ? 
ATOM   1301 O O     . ASP A 1 169 ? -14.103 -1.473  4.722   1.000 12.130 0 169 ASP A O     1 ? 
ATOM   1302 C CB    . ASP A 1 169 ? -15.485 -2.782  2.003   1.000 15.652 0 169 ASP A CB    1 ? 
ATOM   1303 C CG    . ASP A 1 169 ? -16.667 -2.642  2.956   1.000 18.940 0 169 ASP A CG    1 ? 
ATOM   1304 O OD1   . ASP A 1 169 ? -17.220 -3.682  3.307   1.000 25.003 0 169 ASP A OD1   1 ? 
ATOM   1305 O OD2   . ASP A 1 169 ? -16.991 -1.506  3.377   1.000 16.130 0 169 ASP A OD2   1 ? 
ATOM   1306 N N     . ARG A 1 170 ? -12.903 -3.200  3.877   1.000 12.271 0 170 ARG A N     1 ? 
ATOM   1307 C CA    . ARG A 1 170 ? -12.332 -3.647  5.190   1.000 14.472 0 170 ARG A CA    1 ? 
ATOM   1308 C C     . ARG A 1 170 ? -11.501 -2.517  5.811   1.000 12.349 0 170 ARG A C     1 ? 
ATOM   1309 O O     . ARG A 1 170 ? -11.639 -2.233  7.032   1.000 12.196 0 170 ARG A O     1 ? 
ATOM   1310 C CB    . ARG A 1 170 ? -11.544 -4.941  5.026   1.000 14.346 0 170 ARG A CB    1 ? 
ATOM   1311 C CG    . ARG A 1 170 ? -12.413 -6.164  4.732   1.000 19.464 0 170 ARG A CG    1 ? 
ATOM   1312 C CD    . ARG A 1 170 ? -12.729 -7.022  5.910   1.000 21.687 0 170 ARG A CD    1 ? 
ATOM   1313 N NE    . ARG A 1 170 ? -13.906 -7.877  5.761   1.000 24.024 0 170 ARG A NE    1 ? 
ATOM   1314 C CZ    . ARG A 1 170 ? -14.367 -8.673  6.739   1.000 24.738 0 170 ARG A CZ    1 ? 
ATOM   1315 N NH1   . ARG A 1 170 ? -13.709 -8.756  7.887   1.000 26.347 0 170 ARG A NH1   1 ? 
ATOM   1316 N NH2   . ARG A 1 170 ? -15.488 -9.366  6.580   1.000 20.977 0 170 ARG A NH2   1 ? 
ATOM   1317 N N     . ILE A 1 171 ? -10.713 -1.844  5.000   1.000 11.865 0 171 ILE A N     1 ? 
ATOM   1318 C CA    . ILE A 1 171 ? -9.841  -0.734  5.449   1.000 12.591 0 171 ILE A CA    1 ? 
ATOM   1319 C C     . ILE A 1 171 ? -10.706 0.485   5.812   1.000 13.759 0 171 ILE A C     1 ? 
ATOM   1320 O O     . ILE A 1 171 ? -10.513 1.073   6.913   1.000 12.934 0 171 ILE A O     1 ? 
ATOM   1321 C CB    . ILE A 1 171 ? -8.774  -0.442  4.380   1.000 11.529 0 171 ILE A CB    1 ? 
ATOM   1322 C CG1   . ILE A 1 171 ? -7.941  -1.684  4.084   1.000 11.153 0 171 ILE A CG1   1 ? 
ATOM   1323 C CG2   . ILE A 1 171 ? -7.899  0.734   4.797   1.000 12.466 0 171 ILE A CG2   1 ? 
ATOM   1324 C CD1   . ILE A 1 171 ? -7.220  -2.239  5.288   1.000 10.324 0 171 ILE A CD1   1 ? 
ATOM   1325 N N     . ALA A 1 172 ? -11.699 0.803   4.996   1.000 13.025 0 172 ALA A N     1 ? 
ATOM   1326 C CA    . ALA A 1 172 ? -12.652 1.909   5.260   1.000 12.957 0 172 ALA A CA    1 ? 
ATOM   1327 C C     . ALA A 1 172 ? -13.456 1.671   6.548   1.000 12.623 0 172 ALA A C     1 ? 
ATOM   1328 O O     . ALA A 1 172 ? -13.822 2.657   7.205   1.000 15.419 0 172 ALA A O     1 ? 
ATOM   1329 C CB    . ALA A 1 172 ? -13.566 2.086   4.070   1.000 13.176 0 172 ALA A CB    1 ? 
ATOM   1330 N N     . SER A 1 173 ? -13.787 0.433   6.869   1.000 12.920 0 173 SER A N     1 ? 
ATOM   1331 C CA    . SER A 1 173 ? -14.860 0.089   7.841   1.000 14.168 0 173 SER A CA    1 ? 
ATOM   1332 C C     . SER A 1 173 ? -14.288 -0.274  9.216   1.000 13.916 0 173 SER A C     1 ? 
ATOM   1333 O O     . SER A 1 173 ? -15.109 -0.463  10.146  1.000 13.070 0 173 SER A O     1 ? 
ATOM   1334 C CB    . SER A 1 173 ? -15.727 -1.027  7.332   1.000 13.915 0 173 SER A CB    1 ? 
ATOM   1335 O OG    . SER A 1 173 ? -16.336 -0.654  6.098   1.000 17.169 0 173 SER A OG    1 ? 
ATOM   1336 N N     . LYS A 1 174 ? -12.974 -0.478  9.326   1.000 12.260 0 174 LYS A N     1 ? 
ATOM   1337 C CA    . LYS A 1 174 ? -12.374 -1.022  10.576  1.000 14.102 0 174 LYS A CA    1 ? 
ATOM   1338 C C     . LYS A 1 174 ? -12.736 -0.084  11.731  1.000 13.518 0 174 LYS A C     1 ? 
ATOM   1339 O O     . LYS A 1 174 ? -13.103 -0.567  12.806  1.000 14.105 0 174 LYS A O     1 ? 
ATOM   1340 C CB    . LYS A 1 174 ? -10.860 -1.163  10.454  1.000 14.031 0 174 LYS A CB    1 ? 
ATOM   1341 C CG    . LYS A 1 174 ? -10.196 -1.739  11.710  1.000 15.452 0 174 LYS A CG    1 ? 
ATOM   1342 C CD    . LYS A 1 174 ? -8.696  -1.704  11.639  1.000 15.464 0 174 LYS A CD    1 ? 
ATOM   1343 C CE    . LYS A 1 174 ? -7.997  -2.094  12.935  1.000 14.746 0 174 LYS A CE    1 ? 
ATOM   1344 N NZ    . LYS A 1 174 ? -8.402  -3.436  13.403  1.000 14.277 0 174 LYS A NZ    1 ? 
ATOM   1345 N N     . LEU A 1 175 ? -12.663 1.221   11.485  1.000 12.473 0 175 LEU A N     1 ? 
ATOM   1346 C CA    . LEU A 1 175 ? -12.957 2.283   12.467  1.000 12.631 0 175 LEU A CA    1 ? 
ATOM   1347 C C     . LEU A 1 175 ? -13.759 3.360   11.738  1.000 12.607 0 175 LEU A C     1 ? 
ATOM   1348 O O     . LEU A 1 175 ? -13.883 3.268   10.501  1.000 12.292 0 175 LEU A O     1 ? 
ATOM   1349 C CB    . LEU A 1 175 ? -11.627 2.860   12.993  1.000 13.247 0 175 LEU A CB    1 ? 
ATOM   1350 C CG    . LEU A 1 175 ? -10.689 1.859   13.699  1.000 13.816 0 175 LEU A CG    1 ? 
ATOM   1351 C CD1   . LEU A 1 175 ? -9.267  2.396   13.742  1.000 13.537 0 175 LEU A CD1   1 ? 
ATOM   1352 C CD2   . LEU A 1 175 ? -11.177 1.562   15.107  1.000 13.847 0 175 LEU A CD2   1 ? 
ATOM   1353 N N     . SER A 1 176 ? -14.150 4.401   12.451  1.000 11.836 0 176 SER A N     1 ? 
ATOM   1354 C CA    . SER A 1 176 ? -14.850 5.575   11.868  1.000 12.235 0 176 SER A CA    1 ? 
ATOM   1355 C C     . SER A 1 176 ? -14.222 6.893   12.364  1.000 12.356 0 176 SER A C     1 ? 
ATOM   1356 O O     . SER A 1 176 ? -13.427 6.896   13.321  1.000 12.513 0 176 SER A O     1 ? 
ATOM   1357 C CB    . SER A 1 176 ? -16.318 5.479   12.204  1.000 12.532 0 176 SER A CB    1 ? 
ATOM   1358 O OG    . SER A 1 176 ? -16.513 5.784   13.564  1.000 14.844 0 176 SER A OG    1 ? 
ATOM   1359 N N     . GLY A 1 177 ? -14.539 7.997   11.699  1.000 11.498 0 177 GLY A N     1 ? 
ATOM   1360 C CA    . GLY A 1 177 ? -14.267 9.356   12.188  1.000 11.967 0 177 GLY A CA    1 ? 
ATOM   1361 C C     . GLY A 1 177 ? -12.785 9.543   12.485  1.000 11.888 0 177 GLY A C     1 ? 
ATOM   1362 O O     . GLY A 1 177 ? -11.981 9.092   11.688  1.000 10.878 0 177 GLY A O     1 ? 
ATOM   1363 N N     . ASP A 1 178 ? -12.471 10.165  13.608  1.000 11.289 0 178 ASP A N     1 ? 
ATOM   1364 C CA    . ASP A 1 178 ? -11.081 10.567  13.962  1.000 12.515 0 178 ASP A CA    1 ? 
ATOM   1365 C C     . ASP A 1 178 ? -10.284 9.322   14.383  1.000 11.619 0 178 ASP A C     1 ? 
ATOM   1366 O O     . ASP A 1 178 ? -9.071  9.332   14.238  1.000 10.803 0 178 ASP A O     1 ? 
ATOM   1367 C CB    . ASP A 1 178 ? -11.084 11.628  15.055  1.000 12.225 0 178 ASP A CB    1 ? 
ATOM   1368 C CG    . ASP A 1 178 ? -11.564 12.990  14.584  1.000 14.850 0 178 ASP A CG    1 ? 
ATOM   1369 O OD1   . ASP A 1 178 ? -11.682 13.180  13.339  1.000 15.777 0 178 ASP A OD1   1 ? 
ATOM   1370 O OD2   . ASP A 1 178 ? -11.812 13.827  15.454  1.000 14.528 0 178 ASP A OD2   1 ? 
ATOM   1371 N N     . ASP A 1 179 ? -10.935 8.264   14.836  1.000 10.979 0 179 ASP A N     1 ? 
ATOM   1372 C CA    . ASP A 1 179 ? -10.234 6.982   15.073  1.000 11.346 0 179 ASP A CA    1 ? 
ATOM   1373 C C     . ASP A 1 179 ? -9.692  6.439   13.735  1.000 11.244 0 179 ASP A C     1 ? 
ATOM   1374 O O     . ASP A 1 179 ? -8.496  6.036   13.646  1.000 11.220 0 179 ASP A O     1 ? 
ATOM   1375 C CB    . ASP A 1 179 ? -11.153 5.952   15.680  1.000 12.700 0 179 ASP A CB    1 ? 
ATOM   1376 C CG    . ASP A 1 179 ? -11.461 6.145   17.155  1.000 15.565 0 179 ASP A CG    1 ? 
ATOM   1377 O OD1   . ASP A 1 179 ? -10.924 7.102   17.791  1.000 14.763 0 179 ASP A OD1   1 ? 
ATOM   1378 O OD2   . ASP A 1 179 ? -12.264 5.340   17.629  1.000 19.922 0 179 ASP A OD2   1 ? 
ATOM   1379 N N     . ALA A 1 180 ? -10.526 6.396   12.719  1.000 10.371 0 180 ALA A N     1 ? 
ATOM   1380 C CA    . ALA A 1 180 ? -10.121 5.947   11.372  1.000 10.399 0 180 ALA A CA    1 ? 
ATOM   1381 C C     . ALA A 1 180 ? -9.034  6.898   10.832  1.000 10.558 0 180 ALA A C     1 ? 
ATOM   1382 O O     . ALA A 1 180 ? -8.128  6.414   10.156  1.000 10.602 0 180 ALA A O     1 ? 
ATOM   1383 C CB    . ALA A 1 180 ? -11.307 5.864   10.431  1.000 10.755 0 180 ALA A CB    1 ? 
ATOM   1384 N N     . ALA A 1 181 ? -9.097  8.199   11.118  1.000 10.017 0 181 ALA A N     1 ? 
ATOM   1385 C CA    . ALA A 1 181 ? -8.060  9.162   10.665  1.000 9.688  0 181 ALA A CA    1 ? 
ATOM   1386 C C     . ALA A 1 181 ? -6.713  8.790   11.254  1.000 9.458  0 181 ALA A C     1 ? 
ATOM   1387 O O     . ALA A 1 181 ? -5.731  8.819   10.516  1.000 9.077  0 181 ALA A O     1 ? 
ATOM   1388 C CB    . ALA A 1 181 ? -8.409  10.595  11.000  1.000 10.187 0 181 ALA A CB    1 ? 
ATOM   1389 N N     . GLN A 1 182 ? -6.654  8.446   12.536  1.000 9.062  0 182 GLN A N     1 ? 
ATOM   1390 C CA    . GLN A 1 182 ? -5.366  8.051   13.145  1.000 9.108  0 182 GLN A CA    1 ? 
ATOM   1391 C C     . GLN A 1 182 ? -4.835  6.790   12.466  1.000 8.821  0 182 GLN A C     1 ? 
ATOM   1392 O O     . GLN A 1 182 ? -3.650  6.724   12.227  1.000 8.162  0 182 GLN A O     1 ? 
ATOM   1393 C CB    . GLN A 1 182 ? -5.471  7.825   14.652  1.000 9.646  0 182 GLN A CB    1 ? 
ATOM   1394 C CG    . GLN A 1 182 ? -4.099  7.566   15.254  1.000 9.172  0 182 GLN A CG    1 ? 
ATOM   1395 C CD    . GLN A 1 182 ? -4.146  7.435   16.754  1.000 9.974  0 182 GLN A CD    1 ? 
ATOM   1396 O OE1   . GLN A 1 182 ? -3.449  8.147   17.490  1.000 12.067 0 182 GLN A OE1   1 ? 
ATOM   1397 N NE2   . GLN A 1 182 ? -4.874  6.455   17.208  1.000 9.226  0 182 GLN A NE2   1 ? 
ATOM   1398 N N     . PHE A 1 183 ? -5.700  5.813   12.214  1.000 9.100  0 183 PHE A N     1 ? 
ATOM   1399 C CA    . PHE A 1 183 ? -5.375  4.530   11.543  1.000 9.247  0 183 PHE A CA    1 ? 
ATOM   1400 C C     . PHE A 1 183 ? -4.726  4.836   10.188  1.000 9.156  0 183 PHE A C     1 ? 
ATOM   1401 O O     . PHE A 1 183 ? -3.601  4.343   9.930   1.000 8.295  0 183 PHE A O     1 ? 
ATOM   1402 C CB    . PHE A 1 183 ? -6.646  3.680   11.465  1.000 9.135  0 183 PHE A CB    1 ? 
ATOM   1403 C CG    . PHE A 1 183 ? -6.639  2.529   10.518  1.000 9.355  0 183 PHE A CG    1 ? 
ATOM   1404 C CD1   . PHE A 1 183 ? -5.953  1.354   10.805  1.000 10.459 0 183 PHE A CD1   1 ? 
ATOM   1405 C CD2   . PHE A 1 183 ? -7.441  2.569   9.396   1.000 9.849  0 183 PHE A CD2   1 ? 
ATOM   1406 C CE1   . PHE A 1 183 ? -5.997  0.295   9.928   1.000 9.053  0 183 PHE A CE1   1 ? 
ATOM   1407 C CE2   . PHE A 1 183 ? -7.518  1.493   8.539   1.000 9.947  0 183 PHE A CE2   1 ? 
ATOM   1408 C CZ    . PHE A 1 183 ? -6.818  0.353   8.814   1.000 10.092 0 183 PHE A CZ    1 ? 
ATOM   1409 N N     . ARG A 1 184 ? -5.339  5.740   9.426   1.000 9.730  0 184 ARG A N     1 ? 
ATOM   1410 C CA    . ARG A 1 184 ? -4.836  6.167   8.096   1.000 10.238 0 184 ARG A CA    1 ? 
ATOM   1411 C C     . ARG A 1 184 ? -3.509  6.927   8.261   1.000 9.949  0 184 ARG A C     1 ? 
ATOM   1412 O O     . ARG A 1 184 ? -2.589  6.638   7.483   1.000 9.008  0 184 ARG A O     1 ? 
ATOM   1413 C CB    . ARG A 1 184 ? -5.916  6.944   7.334   1.000 10.382 0 184 ARG A CB    1 ? 
ATOM   1414 C CG    . ARG A 1 184 ? -7.067  6.068   6.842   1.000 12.058 0 184 ARG A CG    1 ? 
ATOM   1415 C CD    . ARG A 1 184 ? -8.001  6.723   5.850   1.000 13.280 0 184 ARG A CD    1 ? 
ATOM   1416 N NE    . ARG A 1 184 ? -8.446  8.025   6.341   1.000 14.552 0 184 ARG A NE    1 ? 
ATOM   1417 C CZ    . ARG A 1 184 ? -9.533  8.209   7.102   1.000 17.184 0 184 ARG A CZ    1 ? 
ATOM   1418 N NH1   . ARG A 1 184 ? -10.287 7.181   7.437   1.000 17.467 0 184 ARG A NH1   1 ? 
ATOM   1419 N NH2   . ARG A 1 184 ? -9.866  9.417   7.512   1.000 18.012 0 184 ARG A NH2   1 ? 
ATOM   1420 N N     . ARG A 1 185 ? -3.354  7.758   9.309   1.000 10.389 0 185 ARG A N     1 ? 
ATOM   1421 C CA    . ARG A 1 185 ? -2.106  8.534   9.492   1.000 9.679  0 185 ARG A CA    1 ? 
ATOM   1422 C C     . ARG A 1 185 ? -0.977  7.532   9.711   1.000 9.956  0 185 ARG A C     1 ? 
ATOM   1423 O O     . ARG A 1 185 ? 0.138   7.728   9.145   1.000 9.271  0 185 ARG A O     1 ? 
ATOM   1424 C CB    . ARG A 1 185 ? -2.204  9.522   10.650  1.000 10.022 0 185 ARG A CB    1 ? 
ATOM   1425 C CG    . ARG A 1 185 ? -3.124  10.714  10.394  1.000 9.503  0 185 ARG A CG    1 ? 
ATOM   1426 C CD    . ARG A 1 185 ? -2.784  11.846  11.346  1.000 9.432  0 185 ARG A CD    1 ? 
ATOM   1427 N NE    . ARG A 1 185 ? -3.081  11.547  12.757  1.000 10.000 0 185 ARG A NE    1 ? 
ATOM   1428 C CZ    . ARG A 1 185 ? -4.309  11.594  13.316  1.000 9.458  0 185 ARG A CZ    1 ? 
ATOM   1429 N NH1   . ARG A 1 185 ? -5.368  11.847  12.575  1.000 9.498  0 185 ARG A NH1   1 ? 
ATOM   1430 N NH2   . ARG A 1 185 ? -4.484  11.273  14.582  1.000 8.943  0 185 ARG A NH2   1 ? 
ATOM   1431 N N     . CYS A 1 186 ? -1.246  6.494   10.488  1.000 10.387 0 186 CYS A N     1 ? 
ATOM   1432 C CA    . CYS A 1 186 ? -0.217  5.531   10.927  1.000 10.844 0 186 CYS A CA    1 ? 
ATOM   1433 C C     . CYS A 1 186 ? 0.159   4.636   9.745   1.000 10.062 0 186 CYS A C     1 ? 
ATOM   1434 O O     . CYS A 1 186 ? 1.362   4.367   9.578   1.000 11.531 0 186 CYS A O     1 ? 
ATOM   1435 C CB    . CYS A 1 186 ? -0.661  4.759   12.154  1.000 12.691 0 186 CYS A CB    1 ? 
ATOM   1436 S SG    . CYS A 1 186 ? -0.569  5.769   13.669  1.000 14.629 0 186 CYS A SG    1 ? 
ATOM   1437 N N     . ILE A 1 187 ? -0.770  4.323   8.852   1.000 9.303  0 187 ILE A N     1 ? 
ATOM   1438 C CA    . ILE A 1 187 ? -0.361  3.683   7.572   1.000 8.985  0 187 ILE A CA    1 ? 
ATOM   1439 C C     . ILE A 1 187 ? 0.590   4.620   6.806   1.000 9.211  0 187 ILE A C     1 ? 
ATOM   1440 O O     . ILE A 1 187 ? 1.624   4.151   6.291   1.000 9.194  0 187 ILE A O     1 ? 
ATOM   1441 C CB    . ILE A 1 187 ? -1.602  3.255   6.779   1.000 9.121  0 187 ILE A CB    1 ? 
ATOM   1442 C CG1   . ILE A 1 187 ? -2.348  2.160   7.563   1.000 9.296  0 187 ILE A CG1   1 ? 
ATOM   1443 C CG2   . ILE A 1 187 ? -1.214  2.837   5.364   1.000 8.203  0 187 ILE A CG2   1 ? 
ATOM   1444 C CD1   . ILE A 1 187 ? -3.776  1.919   7.092   1.000 9.356  0 187 ILE A CD1   1 ? 
ATOM   1445 N N     . ARG A 1 188 ? 0.227   5.884   6.641   1.000 9.834  0 188 ARG A N     1 ? 
ATOM   1446 C CA    . ARG A 1 188 ? 1.057   6.829   5.857   1.000 10.001 0 188 ARG A CA    1 ? 
ATOM   1447 C C     . ARG A 1 188 ? 2.435   6.959   6.508   1.000 9.586  0 188 ARG A C     1 ? 
ATOM   1448 O O     . ARG A 1 188 ? 3.417   6.931   5.783   1.000 9.510  0 188 ARG A O     1 ? 
ATOM   1449 C CB    . ARG A 1 188 ? 0.342   8.158   5.738   1.000 10.830 0 188 ARG A CB    1 ? 
ATOM   1450 C CG    . ARG A 1 188 ? -0.838  8.105   4.770   1.000 12.251 0 188 ARG A CG    1 ? 
ATOM   1451 C CD    . ARG A 1 188 ? -1.290  9.526   4.599   1.000 14.280 0 188 ARG A CD    1 ? 
ATOM   1452 N NE    . ARG A 1 188 ? -2.268  9.715   3.556   1.000 14.203 0 188 ARG A NE    1 ? 
ATOM   1453 C CZ    . ARG A 1 188 ? -3.532  9.944   3.774   1.000 18.158 0 188 ARG A CZ    1 ? 
ATOM   1454 N NH1   . ARG A 1 188 ? -3.978  10.049  5.012   1.000 20.437 0 188 ARG A NH1   1 ? 
ATOM   1455 N NH2   . ARG A 1 188 ? -4.346  10.167  2.757   1.000 21.003 0 188 ARG A NH2   1 ? 
ATOM   1456 N N     . TYR A 1 189 ? 2.511   7.013   7.841   1.000 9.382  0 189 TYR A N     1 ? 
ATOM   1457 C CA    . TYR A 1 189 ? 3.803   7.179   8.532   1.000 9.763  0 189 TYR A CA    1 ? 
ATOM   1458 C C     . TYR A 1 189 ? 4.707   6.029   8.124   1.000 10.244 0 189 TYR A C     1 ? 
ATOM   1459 O O     . TYR A 1 189 ? 5.930   6.240   7.868   1.000 10.011 0 189 TYR A O     1 ? 
ATOM   1460 C CB    . TYR A 1 189 ? 3.652   7.250   10.056  1.000 9.643  0 189 TYR A CB    1 ? 
ATOM   1461 C CG    . TYR A 1 189 ? 2.859   8.413   10.609  1.000 9.592  0 189 TYR A CG    1 ? 
ATOM   1462 C CD1   . TYR A 1 189 ? 2.858   9.669   10.014  1.000 10.032 0 189 TYR A CD1   1 ? 
ATOM   1463 C CD2   . TYR A 1 189 ? 2.065   8.245   11.735  1.000 9.196  0 189 TYR A CD2   1 ? 
ATOM   1464 C CE1   . TYR A 1 189 ? 2.114   10.714  10.523  1.000 9.899  0 189 TYR A CE1   1 ? 
ATOM   1465 C CE2   . TYR A 1 189 ? 1.333   9.289   12.273  1.000 9.695  0 189 TYR A CE2   1 ? 
ATOM   1466 C CZ    . TYR A 1 189 ? 1.368   10.538  11.682  1.000 9.798  0 189 TYR A CZ    1 ? 
ATOM   1467 O OH    . TYR A 1 189 ? 0.610   11.549  12.229  1.000 11.131 0 189 TYR A OH    1 ? 
ATOM   1468 N N     . LEU A 1 190 ? 4.190   4.813   8.177   1.000 9.690  0 190 LEU A N     1 ? 
ATOM   1469 C CA    . LEU A 1 190 ? 5.011   3.629   7.866   1.000 10.958 0 190 LEU A CA    1 ? 
ATOM   1470 C C     . LEU A 1 190 ? 5.359   3.587   6.381   1.000 9.543  0 190 LEU A C     1 ? 
ATOM   1471 O O     . LEU A 1 190 ? 6.405   3.060   6.075   1.000 9.899  0 190 LEU A O     1 ? 
ATOM   1472 C CB    . LEU A 1 190 ? 4.267   2.364   8.318   1.000 12.063 0 190 LEU A CB    1 ? 
ATOM   1473 C CG    . LEU A 1 190 ? 4.267   2.169   9.831   1.000 13.962 0 190 LEU A CG    1 ? 
ATOM   1474 C CD1   . LEU A 1 190 ? 3.703   0.814   10.191  1.000 17.839 0 190 LEU A CD1   1 ? 
ATOM   1475 C CD2   . LEU A 1 190 ? 5.668   2.329   10.403  1.000 16.500 0 190 LEU A CD2   1 ? 
ATOM   1476 N N     . LYS A 1 191 ? 4.519   4.116   5.502   1.000 9.469  0 191 LYS A N     1 ? 
ATOM   1477 C CA    . LYS A 1 191 ? 4.860   4.176   4.061   1.000 10.473 0 191 LYS A CA    1 ? 
ATOM   1478 C C     . LYS A 1 191 ? 6.039   5.137   3.849   1.000 10.494 0 191 LYS A C     1 ? 
ATOM   1479 O O     . LYS A 1 191 ? 6.933   4.783   3.088   1.000 9.691  0 191 LYS A O     1 ? 
ATOM   1480 C CB    . LYS A 1 191 ? 3.637   4.537   3.225   1.000 10.846 0 191 LYS A CB    1 ? 
ATOM   1481 C CG    . LYS A 1 191 ? 2.645   3.402   3.067   1.000 13.044 0 191 LYS A CG    1 ? 
ATOM   1482 C CD    . LYS A 1 191 ? 1.531   3.798   2.177   1.000 14.698 0 191 LYS A CD    1 ? 
ATOM   1483 C CE    . LYS A 1 191 ? 0.477   2.755   1.957   1.000 17.521 0 191 LYS A CE    1 ? 
ATOM   1484 N NZ    . LYS A 1 191 ? -0.543  3.295   1.017   1.000 19.362 0 191 LYS A NZ    1 ? 
ATOM   1485 N N     . ARG A 1 192 ? 6.070   6.280   4.549   1.000 10.409 0 192 ARG A N     1 ? 
ATOM   1486 C CA    . ARG A 1 192 ? 7.193   7.229   4.409   1.000 10.379 0 192 ARG A CA    1 ? 
ATOM   1487 C C     . ARG A 1 192 ? 8.457   6.608   5.001   1.000 10.434 0 192 ARG A C     1 ? 
ATOM   1488 O O     . ARG A 1 192 ? 9.513   6.721   4.366   1.000 9.830  0 192 ARG A O     1 ? 
ATOM   1489 C CB    . ARG A 1 192 ? 6.853   8.589   5.027   1.000 11.352 0 192 ARG A CB    1 ? 
ATOM   1490 C CG    . ARG A 1 192 ? 8.003   9.587   4.962   1.000 12.227 0 192 ARG A CG    1 ? 
ATOM   1491 C CD    . ARG A 1 192 ? 8.697   9.716   3.609   1.000 12.942 0 192 ARG A CD    1 ? 
ATOM   1492 N NE    . ARG A 1 192 ? 7.825   10.273  2.576   1.000 13.344 0 192 ARG A NE    1 ? 
ATOM   1493 C CZ    . ARG A 1 192 ? 7.664   11.564  2.280   1.000 16.038 0 192 ARG A CZ    1 ? 
ATOM   1494 N NH1   . ARG A 1 192 ? 8.334   12.523  2.923   1.000 15.416 0 192 ARG A NH1   1 ? 
ATOM   1495 N NH2   . ARG A 1 192 ? 6.861   11.889  1.273   1.000 16.106 0 192 ARG A NH2   1 ? 
ATOM   1496 N N     . TRP A 1 193 ? 8.348   5.934   6.157   1.000 10.579 0 193 TRP A N     1 ? 
ATOM   1497 C CA    . TRP A 1 193 ? 9.472   5.182   6.769   1.000 9.839  0 193 TRP A CA    1 ? 
ATOM   1498 C C     . TRP A 1 193 ? 10.006  4.166   5.764   1.000 10.798 0 193 TRP A C     1 ? 
ATOM   1499 O O     . TRP A 1 193 ? 11.272  4.121   5.554   1.000 11.267 0 193 TRP A O     1 ? 
ATOM   1500 C CB    . TRP A 1 193 ? 9.025   4.504   8.052   1.000 9.192  0 193 TRP A CB    1 ? 
ATOM   1501 C CG    . TRP A 1 193 ? 9.969   3.458   8.538   1.000 8.667  0 193 TRP A CG    1 ? 
ATOM   1502 C CD1   . TRP A 1 193 ? 11.148  3.659   9.197   1.000 8.926  0 193 TRP A CD1   1 ? 
ATOM   1503 C CD2   . TRP A 1 193 ? 9.752   2.023   8.540   1.000 9.088  0 193 TRP A CD2   1 ? 
ATOM   1504 N NE1   . TRP A 1 193 ? 11.713  2.439   9.537   1.000 9.431  0 193 TRP A NE1   1 ? 
ATOM   1505 C CE2   . TRP A 1 193 ? 10.845  1.432   9.220   1.000 8.566  0 193 TRP A CE2   1 ? 
ATOM   1506 C CE3   . TRP A 1 193 ? 8.727   1.181   8.081   1.000 9.023  0 193 TRP A CE3   1 ? 
ATOM   1507 C CZ2   . TRP A 1 193 ? 10.984  0.042   9.326   1.000 8.956  0 193 TRP A CZ2   1 ? 
ATOM   1508 C CZ3   . TRP A 1 193 ? 8.849   -0.190  8.222   1.000 8.175  0 193 TRP A CZ3   1 ? 
ATOM   1509 C CH2   . TRP A 1 193 ? 9.959   -0.744  8.839   1.000 8.501  0 193 TRP A CH2   1 ? 
ATOM   1510 N N     . ARG A 1 194 ? 9.101   3.439   5.127   1.000 11.429 0 194 ARG A N     1 ? 
ATOM   1511 C CA    . ARG A 1 194 ? 9.419   2.425   4.082   1.000 13.691 0 194 ARG A CA    1 ? 
ATOM   1512 C C     . ARG A 1 194 ? 10.231  3.127   2.985   1.000 13.199 0 194 ARG A C     1 ? 
ATOM   1513 O O     . ARG A 1 194 ? 11.318  2.596   2.547   1.000 12.288 0 194 ARG A O     1 ? 
ATOM   1514 C CB    . ARG A 1 194 ? 8.152   1.764   3.534   1.000 16.089 0 194 ARG A CB    1 ? 
ATOM   1515 C CG    . ARG A 1 194 ? 8.402   0.864   2.319   1.000 21.041 0 194 ARG A CG    1 ? 
ATOM   1516 C CD    . ARG A 1 194 ? 7.268   0.844   1.295   1.000 24.643 0 194 ARG A CD    1 ? 
ATOM   1517 N NE    . ARG A 1 194 ? 6.897   2.171   0.865   1.000 25.246 0 194 ARG A NE    1 ? 
ATOM   1518 C CZ    . ARG A 1 194 ? 5.681   2.531   0.429   1.000 27.208 0 194 ARG A CZ    1 ? 
ATOM   1519 N NH1   . ARG A 1 194 ? 4.696   1.646   0.330   1.000 36.202 0 194 ARG A NH1   1 ? 
ATOM   1520 N NH2   . ARG A 1 194 ? 5.456   3.781   0.066   1.000 30.125 0 194 ARG A NH2   1 ? 
ATOM   1521 N N     . ASP A 1 195 ? 9.739   4.265   2.510   1.000 11.968 0 195 ASP A N     1 ? 
ATOM   1522 C CA    . ASP A 1 195 ? 10.381  4.972   1.377   1.000 13.685 0 195 ASP A CA    1 ? 
ATOM   1523 C C     . ASP A 1 195 ? 11.754  5.496   1.806   1.000 13.081 0 195 ASP A C     1 ? 
ATOM   1524 O O     . ASP A 1 195 ? 12.705  5.388   0.988   1.000 13.143 0 195 ASP A O     1 ? 
ATOM   1525 C CB    . ASP A 1 195 ? 9.472   6.076   0.831   1.000 14.519 0 195 ASP A CB    1 ? 
ATOM   1526 C CG    . ASP A 1 195 ? 8.307   5.548   0.032   1.000 15.807 0 195 ASP A CG    1 ? 
ATOM   1527 O OD1   . ASP A 1 195 ? 8.263   4.345   -0.227  1.000 17.642 0 195 ASP A OD1   1 ? 
ATOM   1528 O OD2   . ASP A 1 195 ? 7.402   6.319   -0.223  1.000 21.321 0 195 ASP A OD2   1 ? 
ATOM   1529 N N     . PHE A 1 196 ? 11.898  5.967   3.051   1.000 11.489 0 196 PHE A N     1 ? 
ATOM   1530 C CA    . PHE A 1 196 ? 13.126  6.618   3.514   1.000 12.347 0 196 PHE A CA    1 ? 
ATOM   1531 C C     . PHE A 1 196 ? 14.204  5.551   3.791   1.000 13.039 0 196 PHE A C     1 ? 
ATOM   1532 O O     . PHE A 1 196 ? 15.387  5.817   3.502   1.000 11.998 0 196 PHE A O     1 ? 
ATOM   1533 C CB    . PHE A 1 196 ? 12.825  7.524   4.710   1.000 13.248 0 196 PHE A CB    1 ? 
ATOM   1534 C CG    . PHE A 1 196 ? 14.013  8.281   5.227   1.000 12.864 0 196 PHE A CG    1 ? 
ATOM   1535 C CD1   . PHE A 1 196 ? 14.761  9.099   4.369   1.000 13.649 0 196 PHE A CD1   1 ? 
ATOM   1536 C CD2   . PHE A 1 196 ? 14.484  8.059   6.522   1.000 13.932 0 196 PHE A CD2   1 ? 
ATOM   1537 C CE1   . PHE A 1 196 ? 15.895  9.744   4.840   1.000 14.057 0 196 PHE A CE1   1 ? 
ATOM   1538 C CE2   . PHE A 1 196 ? 15.638  8.694   6.973   1.000 14.436 0 196 PHE A CE2   1 ? 
ATOM   1539 C CZ    . PHE A 1 196 ? 16.318  9.560   6.143   1.000 14.506 0 196 PHE A CZ    1 ? 
ATOM   1540 N N     . ARG A 1 197 ? 13.851  4.436   4.421   1.000 11.871 0 197 ARG A N     1 ? 
ATOM   1541 C CA    . ARG A 1 197 ? 14.864  3.492   4.961   1.000 13.587 0 197 ARG A CA    1 ? 
ATOM   1542 C C     . ARG A 1 197 ? 14.987  2.231   4.118   1.000 12.859 0 197 ARG A C     1 ? 
ATOM   1543 O O     . ARG A 1 197 ? 15.778  1.368   4.487   1.000 12.746 0 197 ARG A O     1 ? 
ATOM   1544 C CB    . ARG A 1 197 ? 14.514  3.115   6.388   1.000 15.605 0 197 ARG A CB    1 ? 
ATOM   1545 C CG    . ARG A 1 197 ? 14.490  4.311   7.316   1.000 16.590 0 197 ARG A CG    1 ? 
ATOM   1546 C CD    . ARG A 1 197 ? 15.281  3.977   8.526   1.000 19.353 0 197 ARG A CD    1 ? 
ATOM   1547 N NE    . ARG A 1 197 ? 16.735  3.978   8.370   1.000 18.025 0 197 ARG A NE    1 ? 
ATOM   1548 C CZ    . ARG A 1 197 ? 17.549  3.276   9.142   1.000 23.453 0 197 ARG A CZ    1 ? 
ATOM   1549 N NH1   . ARG A 1 197 ? 17.042  2.466   10.066  1.000 27.709 0 197 ARG A NH1   1 ? 
ATOM   1550 N NH2   . ARG A 1 197 ? 18.862  3.366   9.001   1.000 18.670 0 197 ARG A NH2   1 ? 
ATOM   1551 N N     . PHE A 1 198 ? 14.216  2.073   3.053   1.000 11.789 0 198 PHE A N     1 ? 
ATOM   1552 C CA    . PHE A 1 198 ? 14.355  0.907   2.169   1.000 13.877 0 198 PHE A CA    1 ? 
ATOM   1553 C C     . PHE A 1 198 ? 14.606  1.400   0.754   1.000 17.528 0 198 PHE A C     1 ? 
ATOM   1554 O O     . PHE A 1 198 ? 14.148  0.729   -0.164  1.000 23.401 0 198 PHE A O     1 ? 
ATOM   1555 C CB    . PHE A 1 198 ? 13.118  -0.015  2.269   1.000 12.927 0 198 PHE A CB    1 ? 
ATOM   1556 C CG    . PHE A 1 198 ? 12.864  -0.628  3.621   1.000 13.495 0 198 PHE A CG    1 ? 
ATOM   1557 C CD1   . PHE A 1 198 ? 12.397  0.145   4.670   1.000 13.432 0 198 PHE A CD1   1 ? 
ATOM   1558 C CD2   . PHE A 1 198 ? 13.070  -1.983  3.841   1.000 13.824 0 198 PHE A CD2   1 ? 
ATOM   1559 C CE1   . PHE A 1 198 ? 12.147  -0.416  5.914   1.000 14.378 0 198 PHE A CE1   1 ? 
ATOM   1560 C CE2   . PHE A 1 198 ? 12.820  -2.545  5.080   1.000 13.635 0 198 PHE A CE2   1 ? 
ATOM   1561 C CZ    . PHE A 1 198 ? 12.388  -1.764  6.125   1.000 14.171 0 198 PHE A CZ    1 ? 
ATOM   1562 N N     . SER A 1 199 ? 15.332  2.513   0.592   1.000 22.119 0 199 SER A N     1 ? 
ATOM   1563 C CA    . SER A 1 199 ? 15.662  3.113   -0.733  1.000 26.936 0 199 SER A CA    1 ? 
ATOM   1564 C C     . SER A 1 199 ? 16.845  2.389   -1.400  1.000 28.300 0 199 SER A C     1 ? 
ATOM   1565 O O     . SER A 1 199 ? 16.949  2.481   -2.646  1.000 26.088 0 199 SER A O     1 ? 
ATOM   1566 C CB    . SER A 1 199 ? 15.927  4.598   -0.624  1.000 26.350 0 199 SER A CB    1 ? 
ATOM   1567 O OG    . SER A 1 199 ? 17.106  4.871   0.117   1.000 29.674 0 199 SER A OG    1 ? 
ATOM   1568 N N     . SER A 1 200 ? 17.709  1.697   -0.641  1.000 28.213 0 200 SER A N     1 ? 
ATOM   1569 C CA    . SER A 1 200 ? 18.938  1.059   -1.206  1.000 31.252 0 200 SER A CA    1 ? 
ATOM   1570 C C     . SER A 1 200 ? 18.560  -0.113  -2.105  1.000 34.044 0 200 SER A C     1 ? 
ATOM   1571 O O     . SER A 1 200 ? 19.267  -0.330  -3.125  1.000 34.971 0 200 SER A O     1 ? 
ATOM   1572 C CB    . SER A 1 200 ? 19.900  0.621   -0.141  1.000 31.915 0 200 SER A CB    1 ? 
ATOM   1573 O OG    . SER A 1 200 ? 20.361  1.734   0.603   1.000 31.156 0 200 SER A OG    1 ? 
ATOM   1574 N N     . ASP A 1 201 ? 17.531  -0.871  -1.697  1.000 32.051 0 201 ASP A N     1 ? 
ATOM   1575 C CA    . ASP A 1 201 ? 17.082  -2.132  -2.336  1.000 32.410 0 201 ASP A CA    1 ? 
ATOM   1576 C C     . ASP A 1 201 ? 15.546  -2.137  -2.341  1.000 31.998 0 201 ASP A C     1 ? 
ATOM   1577 O O     . ASP A 1 201 ? 14.961  -2.735  -1.423  1.000 28.172 0 201 ASP A O     1 ? 
ATOM   1578 C CB    . ASP A 1 201 ? 17.670  -3.344  -1.601  1.000 32.740 0 201 ASP A CB    1 ? 
ATOM   1579 C CG    . ASP A 1 201 ? 17.477  -4.657  -2.331  1.000 38.207 0 201 ASP A CG    1 ? 
ATOM   1580 O OD1   . ASP A 1 201 ? 16.824  -4.664  -3.410  1.000 40.833 0 201 ASP A OD1   1 ? 
ATOM   1581 O OD2   . ASP A 1 201 ? 17.985  -5.666  -1.826  1.000 45.486 0 201 ASP A OD2   1 ? 
ATOM   1582 N N     . GLY A 1 202 ? 14.935  -1.470  -3.324  1.000 32.436 0 202 GLY A N     1 ? 
ATOM   1583 C CA    . GLY A 1 202 ? 13.477  -1.469  -3.571  1.000 36.549 0 202 GLY A CA    1 ? 
ATOM   1584 C C     . GLY A 1 202 ? 12.846  -2.839  -3.367  1.000 37.319 0 202 GLY A C     1 ? 
ATOM   1585 O O     . GLY A 1 202 ? 11.725  -2.880  -2.835  1.000 39.115 0 202 GLY A O     1 ? 
ATOM   1586 N N     . ASN A 1 203 ? 13.525  -3.917  -3.789  1.000 38.790 0 203 ASN A N     1 ? 
ATOM   1587 C CA    . ASN A 1 203 ? 13.004  -5.319  -3.775  1.000 40.209 0 203 ASN A CA    1 ? 
ATOM   1588 C C     . ASN A 1 203 ? 12.778  -5.801  -2.341  1.000 33.891 0 203 ASN A C     1 ? 
ATOM   1589 O O     . ASN A 1 203 ? 11.843  -6.575  -2.122  1.000 37.783 0 203 ASN A O     1 ? 
ATOM   1590 C CB    . ASN A 1 203 ? 13.953  -6.310  -4.460  1.000 46.812 0 203 ASN A CB    1 ? 
ATOM   1591 C CG    . ASN A 1 203 ? 14.308  -5.893  -5.870  1.000 49.454 0 203 ASN A CG    1 ? 
ATOM   1592 O OD1   . ASN A 1 203 ? 13.564  -5.151  -6.509  1.000 51.137 0 203 ASN A OD1   1 ? 
ATOM   1593 N ND2   . ASN A 1 203 ? 15.466  -6.325  -6.345  1.000 59.145 0 203 ASN A ND2   1 ? 
ATOM   1594 N N     . ALA A 1 204 ? 13.658  -5.403  -1.425  1.000 30.608 0 204 ALA A N     1 ? 
ATOM   1595 C CA    . ALA A 1 204 ? 13.625  -5.761  0.005   1.000 26.099 0 204 ALA A CA    1 ? 
ATOM   1596 C C     . ALA A 1 204 ? 12.534  -4.971  0.733   1.000 26.670 0 204 ALA A C     1 ? 
ATOM   1597 O O     . ALA A 1 204 ? 12.393  -5.216  1.926   1.000 26.151 0 204 ALA A O     1 ? 
ATOM   1598 C CB    . ALA A 1 204 ? 14.978  -5.503  0.627   1.000 25.959 0 204 ALA A CB    1 ? 
ATOM   1599 N N     . ALA A 1 205 ? 11.903  -3.959  0.097   1.000 25.002 0 205 ALA A N     1 ? 
ATOM   1600 C CA    . ALA A 1 205 ? 11.027  -3.013  0.824   1.000 24.062 0 205 ALA A CA    1 ? 
ATOM   1601 C C     . ALA A 1 205 ? 9.689   -3.701  1.092   1.000 24.196 0 205 ALA A C     1 ? 
ATOM   1602 O O     . ALA A 1 205 ? 9.113   -4.336  0.203   1.000 22.123 0 205 ALA A O     1 ? 
ATOM   1603 C CB    . ALA A 1 205 ? 10.865  -1.697  0.090   1.000 25.906 0 205 ALA A CB    1 ? 
ATOM   1604 N N     . PRO A 1 206 ? 9.148   -3.604  2.325   1.000 22.403 0 206 PRO A N     1 ? 
ATOM   1605 C CA    . PRO A 1 206 ? 7.781   -4.063  2.584   1.000 23.504 0 206 PRO A CA    1 ? 
ATOM   1606 C C     . PRO A 1 206 ? 6.743   -3.330  1.700   1.000 24.422 0 206 PRO A C     1 ? 
ATOM   1607 O O     . PRO A 1 206 ? 6.745   -2.129  1.690   1.000 26.981 0 206 PRO A O     1 ? 
ATOM   1608 C CB    . PRO A 1 206 ? 7.579   -3.754  4.075   1.000 22.683 0 206 PRO A CB    1 ? 
ATOM   1609 C CG    . PRO A 1 206 ? 8.602   -2.689  4.405   1.000 25.826 0 206 PRO A CG    1 ? 
ATOM   1610 C CD    . PRO A 1 206 ? 9.785   -2.987  3.501   1.000 23.857 0 206 PRO A CD    1 ? 
ATOM   1611 N N     . LEU A 1 207 ? 5.902   -4.059  0.974   1.000 22.871 0 207 LEU A N     1 ? 
ATOM   1612 C CA    . LEU A 1 207 ? 4.846   -3.463  0.105   1.000 23.814 0 207 LEU A CA    1 ? 
ATOM   1613 C C     . LEU A 1 207 ? 3.885   -2.615  0.955   1.000 22.582 0 207 LEU A C     1 ? 
ATOM   1614 O O     . LEU A 1 207 ? 3.584   -3.015  2.086   1.000 22.300 0 207 LEU A O     1 ? 
ATOM   1615 C CB    . LEU A 1 207 ? 4.110   -4.591  -0.613  1.000 27.659 0 207 LEU A CB    1 ? 
ATOM   1616 C CG    . LEU A 1 207 ? 4.954   -5.390  -1.608  1.000 30.336 0 207 LEU A CG    1 ? 
ATOM   1617 C CD1   . LEU A 1 207 ? 4.274   -6.711  -1.964  1.000 34.470 0 207 LEU A CD1   1 ? 
ATOM   1618 C CD2   . LEU A 1 207 ? 5.215   -4.565  -2.865  1.000 32.688 0 207 LEU A CD2   1 ? 
ATOM   1619 N N     . GLY A 1 208 ? 3.448   -1.475  0.428   1.000 20.246 0 208 GLY A N     1 ? 
ATOM   1620 C CA    . GLY A 1 208 ? 2.391   -0.639  1.023   1.000 19.160 0 208 GLY A CA    1 ? 
ATOM   1621 C C     . GLY A 1 208 ? 1.192   -1.492  1.388   1.000 16.787 0 208 GLY A C     1 ? 
ATOM   1622 O O     . GLY A 1 208 ? 0.655   -1.306  2.482   1.000 16.926 0 208 GLY A O     1 ? 
ATOM   1623 N N     . ILE A 1 209 ? 0.797   -2.422  0.517   1.000 17.923 0 209 ILE A N     1 ? 
ATOM   1624 C CA    . ILE A 1 209 ? -0.376  -3.330  0.757   1.000 17.080 0 209 ILE A CA    1 ? 
ATOM   1625 C C     . ILE A 1 209 ? -0.150  -4.155  2.040   1.000 15.384 0 209 ILE A C     1 ? 
ATOM   1626 O O     . ILE A 1 209 ? -1.136  -4.419  2.785   1.000 14.965 0 209 ILE A O     1 ? 
ATOM   1627 C CB    . ILE A 1 209 ? -0.631  -4.235  -0.464  1.000 20.951 0 209 ILE A CB    1 ? 
ATOM   1628 C CG1   . ILE A 1 209 ? -1.857  -5.112  -0.253  1.000 25.739 0 209 ILE A CG1   1 ? 
ATOM   1629 C CG2   . ILE A 1 209 ? 0.578   -5.101  -0.764  1.000 21.197 0 209 ILE A CG2   1 ? 
ATOM   1630 C CD1   . ILE A 1 209 ? -3.060  -4.364  0.164   1.000 28.339 0 209 ILE A CD1   1 ? 
ATOM   1631 N N     . GLY A 1 210 ? 1.091   -4.556  2.292   1.000 14.360 0 210 GLY A N     1 ? 
ATOM   1632 C CA    . GLY A 1 210 ? 1.491   -5.362  3.454   1.000 13.393 0 210 GLY A CA    1 ? 
ATOM   1633 C C     . GLY A 1 210 ? 1.436   -4.547  4.726   1.000 13.105 0 210 GLY A C     1 ? 
ATOM   1634 O O     . GLY A 1 210 ? 0.892   -5.040  5.718   1.000 13.593 0 210 GLY A O     1 ? 
ATOM   1635 N N     . LEU A 1 211 ? 1.869   -3.283  4.685   1.000 12.278 0 211 LEU A N     1 ? 
ATOM   1636 C CA    . LEU A 1 211 ? 1.767   -2.399  5.872   1.000 12.930 0 211 LEU A CA    1 ? 
ATOM   1637 C C     . LEU A 1 211 ? 0.279   -2.137  6.136   1.000 11.052 0 211 LEU A C     1 ? 
ATOM   1638 O O     . LEU A 1 211 ? -0.094  -2.085  7.298   1.000 9.685  0 211 LEU A O     1 ? 
ATOM   1639 C CB    . LEU A 1 211 ? 2.546   -1.105  5.626   1.000 14.564 0 211 LEU A CB    1 ? 
ATOM   1640 C CG    . LEU A 1 211 ? 4.013   -1.316  5.241   1.000 16.013 0 211 LEU A CG    1 ? 
ATOM   1641 C CD1   . LEU A 1 211 ? 4.609   -0.032  4.697   1.000 19.022 0 211 LEU A CD1   1 ? 
ATOM   1642 C CD2   . LEU A 1 211 ? 4.796   -1.824  6.412   1.000 16.134 0 211 LEU A CD2   1 ? 
ATOM   1643 N N     . THR A 1 212 ? -0.534  -1.982  5.095   1.000 10.105 0 212 THR A N     1 ? 
ATOM   1644 C CA    . THR A 1 212 ? -1.970  -1.674  5.231   1.000 10.403 0 212 THR A CA    1 ? 
ATOM   1645 C C     . THR A 1 212 ? -2.704  -2.875  5.880   1.000 10.714 0 212 THR A C     1 ? 
ATOM   1646 O O     . THR A 1 212 ? -3.495  -2.654  6.765   1.000 10.598 0 212 THR A O     1 ? 
ATOM   1647 C CB    . THR A 1 212 ? -2.570  -1.297  3.864   1.000 10.869 0 212 THR A CB    1 ? 
ATOM   1648 O OG1   . THR A 1 212 ? -1.886  -0.133  3.385   1.000 11.059 0 212 THR A OG1   1 ? 
ATOM   1649 C CG2   . THR A 1 212 ? -4.040  -1.023  3.912   1.000 12.153 0 212 THR A CG2   1 ? 
ATOM   1650 N N     . ALA A 1 213 ? -2.501  -4.075  5.361   1.000 10.284 0 213 ALA A N     1 ? 
ATOM   1651 C CA    . ALA A 1 213 ? -3.080  -5.324  5.897   1.000 9.864  0 213 ALA A CA    1 ? 
ATOM   1652 C C     . ALA A 1 213 ? -2.584  -5.499  7.341   1.000 9.887  0 213 ALA A C     1 ? 
ATOM   1653 O O     . ALA A 1 213 ? -3.410  -5.814  8.194   1.000 8.987  0 213 ALA A O     1 ? 
ATOM   1654 C CB    . ALA A 1 213 ? -2.698  -6.471  5.022   1.000 10.358 0 213 ALA A CB    1 ? 
ATOM   1655 N N     . ALA A 1 214 ? -1.298  -5.218  7.629   1.000 9.196  0 214 ALA A N     1 ? 
ATOM   1656 C CA    . ALA A 1 214 ? -0.751  -5.340  9.007   1.000 9.744  0 214 ALA A CA    1 ? 
ATOM   1657 C C     . ALA A 1 214 ? -1.560  -4.417  9.938   1.000 9.413  0 214 ALA A C     1 ? 
ATOM   1658 O O     . ALA A 1 214 ? -1.985  -4.858  11.051  1.000 11.068 0 214 ALA A O     1 ? 
ATOM   1659 C CB    . ALA A 1 214 ? 0.736   -5.030  9.047   1.000 10.023 0 214 ALA A CB    1 ? 
ATOM   1660 N N     . ALA A 1 215 ? -1.791  -3.164  9.513   1.000 9.925  0 215 ALA A N     1 ? 
ATOM   1661 C CA    . ALA A 1 215 ? -2.591  -2.177  10.254  1.000 9.537  0 215 ALA A CA    1 ? 
ATOM   1662 C C     . ALA A 1 215 ? -4.014  -2.715  10.453  1.000 9.971  0 215 ALA A C     1 ? 
ATOM   1663 O O     . ALA A 1 215 ? -4.530  -2.630  11.585  1.000 9.367  0 215 ALA A O     1 ? 
ATOM   1664 C CB    . ALA A 1 215 ? -2.551  -0.827  9.557   1.000 9.365  0 215 ALA A CB    1 ? 
ATOM   1665 N N     . TYR A 1 216 ? -4.633  -3.261  9.414   1.000 10.649 0 216 TYR A N     1 ? 
ATOM   1666 C CA    . TYR A 1 216 ? -5.981  -3.869  9.540   1.000 11.291 0 216 TYR A CA    1 ? 
ATOM   1667 C C     . TYR A 1 216 ? -5.986  -4.898  10.682  1.000 11.918 0 216 TYR A C     1 ? 
ATOM   1668 O O     . TYR A 1 216 ? -6.943  -4.929  11.521  1.000 10.774 0 216 TYR A O     1 ? 
ATOM   1669 C CB    . TYR A 1 216 ? -6.408  -4.524  8.238   1.000 12.541 0 216 TYR A CB    1 ? 
ATOM   1670 C CG    . TYR A 1 216 ? -7.631  -5.377  8.409   1.000 12.912 0 216 TYR A CG    1 ? 
ATOM   1671 C CD1   . TYR A 1 216 ? -8.882  -4.816  8.293   1.000 13.762 0 216 TYR A CD1   1 ? 
ATOM   1672 C CD2   . TYR A 1 216 ? -7.544  -6.734  8.716   1.000 14.432 0 216 TYR A CD2   1 ? 
ATOM   1673 C CE1   . TYR A 1 216 ? -10.023 -5.581  8.448   1.000 14.774 0 216 TYR A CE1   1 ? 
ATOM   1674 C CE2   . TYR A 1 216 ? -8.687  -7.494  8.935   1.000 16.326 0 216 TYR A CE2   1 ? 
ATOM   1675 C CZ    . TYR A 1 216 ? -9.934  -6.905  8.801   1.000 16.413 0 216 TYR A CZ    1 ? 
ATOM   1676 O OH    . TYR A 1 216 ? -11.086 -7.651  8.948   1.000 20.535 0 216 TYR A OH    1 ? 
ATOM   1677 N N     . TRP A 1 217 ? -4.980  -5.765  10.735  1.000 11.452 0 217 TRP A N     1 ? 
ATOM   1678 C CA    . TRP A 1 217 ? -4.957  -6.832  11.777  1.000 11.871 0 217 TRP A CA    1 ? 
ATOM   1679 C C     . TRP A 1 217 ? -4.656  -6.243  13.168  1.000 12.224 0 217 TRP A C     1 ? 
ATOM   1680 O O     . TRP A 1 217 ? -5.284  -6.694  14.130  1.000 12.874 0 217 TRP A O     1 ? 
ATOM   1681 C CB    . TRP A 1 217 ? -3.988  -7.962  11.421  1.000 12.570 0 217 TRP A CB    1 ? 
ATOM   1682 C CG    . TRP A 1 217 ? -4.388  -8.758  10.224  1.000 13.251 0 217 TRP A CG    1 ? 
ATOM   1683 C CD1   . TRP A 1 217 ? -3.729  -8.845  9.042   1.000 12.830 0 217 TRP A CD1   1 ? 
ATOM   1684 C CD2   . TRP A 1 217 ? -5.539  -9.610  10.109  1.000 14.846 0 217 TRP A CD2   1 ? 
ATOM   1685 N NE1   . TRP A 1 217 ? -4.394  -9.674  8.193   1.000 13.211 0 217 TRP A NE1   1 ? 
ATOM   1686 C CE2   . TRP A 1 217 ? -5.527  -10.136 8.808   1.000 14.800 0 217 TRP A CE2   1 ? 
ATOM   1687 C CE3   . TRP A 1 217 ? -6.576  -9.973  10.980  1.000 16.857 0 217 TRP A CE3   1 ? 
ATOM   1688 C CZ2   . TRP A 1 217 ? -6.484  -11.045 8.368   1.000 16.483 0 217 TRP A CZ2   1 ? 
ATOM   1689 C CZ3   . TRP A 1 217 ? -7.535  -10.863 10.530  1.000 18.632 0 217 TRP A CZ3   1 ? 
ATOM   1690 C CH2   . TRP A 1 217 ? -7.483  -11.393 9.247   1.000 17.107 0 217 TRP A CH2   1 ? 
ATOM   1691 N N     . TRP A 1 218 ? -3.723  -5.296  13.299  1.000 11.599 0 218 TRP A N     1 ? 
ATOM   1692 C CA    . TRP A 1 218 ? -3.003  -5.053  14.563  1.000 11.188 0 218 TRP A CA    1 ? 
ATOM   1693 C C     . TRP A 1 218 ? -3.080  -3.599  15.045  1.000 11.655 0 218 TRP A C     1 ? 
ATOM   1694 O O     . TRP A 1 218 ? -2.724  -3.370  16.206  1.000 12.573 0 218 TRP A O     1 ? 
ATOM   1695 C CB    . TRP A 1 218 ? -1.551  -5.544  14.427  1.000 10.926 0 218 TRP A CB    1 ? 
ATOM   1696 C CG    . TRP A 1 218 ? -1.422  -7.026  14.202  1.000 10.878 0 218 TRP A CG    1 ? 
ATOM   1697 C CD1   . TRP A 1 218 ? -2.087  -8.023  14.852  1.000 12.607 0 218 TRP A CD1   1 ? 
ATOM   1698 C CD2   . TRP A 1 218 ? -0.546  -7.685  13.284  1.000 11.997 0 218 TRP A CD2   1 ? 
ATOM   1699 N NE1   . TRP A 1 218 ? -1.715  -9.250  14.374  1.000 11.649 0 218 TRP A NE1   1 ? 
ATOM   1700 C CE2   . TRP A 1 218 ? -0.781  -9.083  13.411  1.000 12.183 0 218 TRP A CE2   1 ? 
ATOM   1701 C CE3   . TRP A 1 218 ? 0.355   -7.241  12.314  1.000 12.082 0 218 TRP A CE3   1 ? 
ATOM   1702 C CZ2   . TRP A 1 218 ? -0.126  -10.017 12.634  1.000 12.126 0 218 TRP A CZ2   1 ? 
ATOM   1703 C CZ3   . TRP A 1 218 ? 1.006   -8.171  11.542  1.000 13.204 0 218 TRP A CZ3   1 ? 
ATOM   1704 C CH2   . TRP A 1 218 ? 0.792   -9.541  11.727  1.000 13.385 0 218 TRP A CH2   1 ? 
ATOM   1705 N N     . PHE A 1 219 ? -3.466  -2.628  14.226  1.000 11.850 0 219 PHE A N     1 ? 
ATOM   1706 C CA    . PHE A 1 219 ? -3.516  -1.212  14.684  1.000 11.229 0 219 PHE A CA    1 ? 
ATOM   1707 C C     . PHE A 1 219 ? -4.538  -1.036  15.812  1.000 11.261 0 219 PHE A C     1 ? 
ATOM   1708 O O     . PHE A 1 219 ? -5.680  -1.563  15.714  1.000 13.636 0 219 PHE A O     1 ? 
ATOM   1709 C CB    . PHE A 1 219 ? -3.949  -0.267  13.575  1.000 12.118 0 219 PHE A CB    1 ? 
ATOM   1710 C CG    . PHE A 1 219 ? -4.120  1.147   14.050  1.000 11.533 0 219 PHE A CG    1 ? 
ATOM   1711 C CD1   . PHE A 1 219 ? -3.016  1.956   14.254  1.000 12.010 0 219 PHE A CD1   1 ? 
ATOM   1712 C CD2   . PHE A 1 219 ? -5.371  1.655   14.329  1.000 12.597 0 219 PHE A CD2   1 ? 
ATOM   1713 C CE1   . PHE A 1 219 ? -3.180  3.272   14.652  1.000 12.741 0 219 PHE A CE1   1 ? 
ATOM   1714 C CE2   . PHE A 1 219 ? -5.526  2.953   14.784  1.000 12.539 0 219 PHE A CE2   1 ? 
ATOM   1715 C CZ    . PHE A 1 219 ? -4.430  3.749   14.971  1.000 12.509 0 219 PHE A CZ    1 ? 
ATOM   1716 N N     . GLN A 1 220 ? -4.165  -0.304  16.850  1.000 11.340 0 220 GLN A N     1 ? 
ATOM   1717 C CA    . GLN A 1 220 ? -5.087  0.144   17.941  1.000 12.098 0 220 GLN A CA    1 ? 
ATOM   1718 C C     . GLN A 1 220 ? -5.032  1.664   18.103  1.000 10.912 0 220 GLN A C     1 ? 
ATOM   1719 O O     . GLN A 1 220 ? -3.941  2.224   18.174  1.000 11.292 0 220 GLN A O     1 ? 
ATOM   1720 C CB    . GLN A 1 220 ? -4.709  -0.532  19.247  1.000 14.681 0 220 GLN A CB    1 ? 
ATOM   1721 C CG    . GLN A 1 220 ? -4.799  -2.041  19.173  1.000 17.369 0 220 GLN A CG    1 ? 
ATOM   1722 C CD    . GLN A 1 220 ? -6.217  -2.529  19.046  1.000 21.377 0 220 GLN A CD    1 ? 
ATOM   1723 O OE1   . GLN A 1 220 ? -7.172  -1.827  19.356  1.000 23.827 0 220 GLN A OE1   1 ? 
ATOM   1724 N NE2   . GLN A 1 220 ? -6.362  -3.759  18.578  1.000 26.510 0 220 GLN A NE2   1 ? 
ATOM   1725 N N     . VAL A 1 221 ? -6.183  2.284   18.258  1.000 11.358 0 221 VAL A N     1 ? 
ATOM   1726 C CA    . VAL A 1 221 ? -6.319  3.737   18.495  1.000 12.079 0 221 VAL A CA    1 ? 
ATOM   1727 C C     . VAL A 1 221 ? -5.604  4.049   19.801  1.000 11.929 0 221 VAL A C     1 ? 
ATOM   1728 O O     . VAL A 1 221 ? -5.626  3.203   20.702  1.000 11.946 0 221 VAL A O     1 ? 
ATOM   1729 C CB    . VAL A 1 221 ? -7.798  4.183   18.513  1.000 14.012 0 221 VAL A CB    1 ? 
ATOM   1730 C CG1   . VAL A 1 221 ? -7.957  5.595   19.022  1.000 15.111 0 221 VAL A CG1   1 ? 
ATOM   1731 C CG2   . VAL A 1 221 ? -8.437  4.049   17.148  1.000 14.617 0 221 VAL A CG2   1 ? 
ATOM   1732 N N     . SER A 1 222 ? -4.917  5.176   19.860  1.000 11.428 0 222 SER A N     1 ? 
ATOM   1733 C CA    . SER A 1 222 ? -4.401  5.766   21.130  1.000 13.035 0 222 SER A CA    1 ? 
ATOM   1734 C C     . SER A 1 222 ? -4.932  7.181   21.235  1.000 14.025 0 222 SER A C     1 ? 
ATOM   1735 O O     . SER A 1 222 ? -4.583  8.055   20.398  1.000 12.887 0 222 SER A O     1 ? 
ATOM   1736 C CB    . SER A 1 222 ? -2.901  5.724   21.229  1.000 11.773 0 222 SER A CB    1 ? 
ATOM   1737 O OG    . SER A 1 222 ? -2.447  6.298   22.463  1.000 11.083 0 222 SER A OG    1 ? 
ATOM   1738 N N     . LYS A 1 223 ? -5.782  7.391   22.219  1.000 14.736 0 223 LYS A N     1 ? 
ATOM   1739 C CA    . LYS A 1 223 ? -6.347  8.716   22.475  1.000 15.270 0 223 LYS A CA    1 ? 
ATOM   1740 C C     . LYS A 1 223 ? -6.609  8.852   23.981  1.000 17.890 0 223 LYS A C     1 ? 
ATOM   1741 O O     . LYS A 1 223 ? -6.710  7.842   24.668  1.000 18.143 0 223 LYS A O     1 ? 
ATOM   1742 C CB    . LYS A 1 223 ? -7.611  8.921   21.642  1.000 15.900 0 223 LYS A CB    1 ? 
ATOM   1743 C CG    . LYS A 1 223 ? -8.758  7.974   21.945  1.000 16.238 0 223 LYS A CG    1 ? 
ATOM   1744 C CD    . LYS A 1 223 ? -9.954  8.198   21.091  1.000 16.731 0 223 LYS A CD    1 ? 
ATOM   1745 C CE    . LYS A 1 223 ? -10.965 7.083   21.264  1.000 17.290 0 223 LYS A CE    1 ? 
ATOM   1746 N NZ    . LYS A 1 223 ? -12.132 7.294   20.387  1.000 18.181 0 223 LYS A NZ    1 ? 
ATOM   1747 N N     . ARG A 1 224 ? -6.841  10.069  24.415  1.000 23.325 0 224 ARG A N     1 ? 
ATOM   1748 C CA    . ARG A 1 224 ? -7.255  10.352  25.811  1.000 27.065 0 224 ARG A CA    1 ? 
ATOM   1749 C C     . ARG A 1 224 ? -8.375  11.376  25.805  1.000 28.803 0 224 ARG A C     1 ? 
ATOM   1750 O O     . ARG A 1 224 ? -8.325  12.296  24.955  1.000 27.307 0 224 ARG A O     1 ? 
ATOM   1751 C CB    . ARG A 1 224 ? -6.064  10.881  26.585  1.000 29.017 0 224 ARG A CB    1 ? 
ATOM   1752 C CG    . ARG A 1 224 ? -4.961  9.851   26.727  1.000 36.431 0 224 ARG A CG    1 ? 
ATOM   1753 C CD    . ARG A 1 224 ? -3.930  10.328  27.710  1.000 39.500 0 224 ARG A CD    1 ? 
ATOM   1754 N NE    . ARG A 1 224 ? -4.509  10.576  29.023  1.000 41.782 0 224 ARG A NE    1 ? 
ATOM   1755 C CZ    . ARG A 1 224 ? -3.826  11.066  30.040  1.000 46.774 0 224 ARG A CZ    1 ? 
ATOM   1756 N NH1   . ARG A 1 224 ? -2.550  11.383  29.881  1.000 45.987 0 224 ARG A NH1   1 ? 
ATOM   1757 N NH2   . ARG A 1 224 ? -4.419  11.257  31.201  1.000 51.102 0 224 ARG A NH2   1 ? 
ATOM   1758 N N     . THR A 1 225 ? -9.313  11.191  26.741  1.000 33.446 0 225 THR A N     1 ? 
ATOM   1759 C CA    . THR A 1 225 ? -10.567 11.959  26.909  1.000 34.297 0 225 THR A CA    1 ? 
ATOM   1760 C C     . THR A 1 225 ? -10.468 12.641  28.269  1.000 34.503 0 225 THR A C     1 ? 
ATOM   1761 O O     . THR A 1 225 ? -10.378 11.910  29.264  1.000 31.626 0 225 THR A O     1 ? 
ATOM   1762 C CB    . THR A 1 225 ? -11.772 11.019  26.765  1.000 37.575 0 225 THR A CB    1 ? 
ATOM   1763 O OG1   . THR A 1 225 ? -11.541 10.228  25.595  1.000 40.733 0 225 THR A OG1   1 ? 
ATOM   1764 C CG2   . THR A 1 225 ? -13.103 11.736  26.678  1.000 39.192 0 225 THR A CG2   1 ? 
ATOM   1765 N N     . ASP A 1 226 ? -10.289 13.961  28.273  1.000 35.445 0 226 ASP A N     1 ? 
ATOM   1766 C CA    . ASP A 1 226 ? -10.078 14.781  29.494  1.000 38.489 0 226 ASP A CA    1 ? 
ATOM   1767 C C     . ASP A 1 226 ? -11.205 14.477  30.479  1.000 40.797 0 226 ASP A C     1 ? 
ATOM   1768 O O     . ASP A 1 226 ? -12.370 14.407  30.085  1.000 37.661 0 226 ASP A O     1 ? 
ATOM   1769 C CB    . ASP A 1 226 ? -10.029 16.269  29.151  1.000 36.122 0 226 ASP A CB    1 ? 
ATOM   1770 C CG    . ASP A 1 226 ? -9.380  17.120  30.217  1.000 41.104 0 226 ASP A CG    1 ? 
ATOM   1771 O OD1   . ASP A 1 226 ? -9.764  18.301  30.334  1.000 52.777 0 226 ASP A OD1   1 ? 
ATOM   1772 O OD2   . ASP A 1 226 ? -8.493  16.603  30.917  1.000 44.381 0 226 ASP A OD2   1 ? 
ATOM   1773 N N     . PRO A 1 227 ? -10.926 14.273  31.785  1.000 42.445 0 227 PRO A N     1 ? 
ATOM   1774 C CA    . PRO A 1 227 ? -11.988 13.892  32.714  1.000 42.852 0 227 PRO A CA    1 ? 
ATOM   1775 C C     . PRO A 1 227 ? -12.924 15.081  33.014  1.000 44.617 0 227 PRO A C     1 ? 
ATOM   1776 O O     . PRO A 1 227 ? -13.983 14.841  33.609  1.000 47.989 0 227 PRO A O     1 ? 
ATOM   1777 C CB    . PRO A 1 227 ? -11.251 13.403  33.979  1.000 42.339 0 227 PRO A CB    1 ? 
ATOM   1778 C CG    . PRO A 1 227 ? -9.750  13.492  33.647  1.000 44.033 0 227 PRO A CG    1 ? 
ATOM   1779 C CD    . PRO A 1 227 ? -9.625  14.418  32.452  1.000 44.706 0 227 PRO A CD    1 ? 
ATOM   1780 N N     . VAL A 1 228 ? -12.535 16.306  32.606  1.000 40.324 0 228 VAL A N     1 ? 
ATOM   1781 C CA    . VAL A 1 228 ? -13.281 17.568  32.893  1.000 41.264 0 228 VAL A CA    1 ? 
ATOM   1782 C C     . VAL A 1 228 ? -14.123 17.948  31.670  1.000 39.482 0 228 VAL A C     1 ? 
ATOM   1783 O O     . VAL A 1 228 ? -15.365 18.054  31.812  1.000 41.434 0 228 VAL A O     1 ? 
ATOM   1784 C CB    . VAL A 1 228 ? -12.352 18.734  33.291  1.000 43.535 0 228 VAL A CB    1 ? 
ATOM   1785 C CG1   . VAL A 1 228 ? -13.153 19.896  33.876  1.000 42.052 0 228 VAL A CG1   1 ? 
ATOM   1786 C CG2   . VAL A 1 228 ? -11.240 18.305  34.238  1.000 45.876 0 228 VAL A CG2   1 ? 
ATOM   1787 N N     . SER A 1 229 ? -13.463 18.212  30.543  1.000 34.279 0 229 SER A N     1 ? 
ATOM   1788 C CA    . SER A 1 229 ? -14.055 18.749  29.289  1.000 33.982 0 229 SER A CA    1 ? 
ATOM   1789 C C     . SER A 1 229 ? -14.559 17.614  28.390  1.000 31.505 0 229 SER A C     1 ? 
ATOM   1790 O O     . SER A 1 229 ? -15.334 17.906  27.466  1.000 28.888 0 229 SER A O     1 ? 
ATOM   1791 C CB    . SER A 1 229 ? -13.028 19.533  28.541  1.000 32.811 0 229 SER A CB    1 ? 
ATOM   1792 O OG    . SER A 1 229 ? -11.985 18.648  28.179  1.000 26.495 0 229 SER A OG    1 ? 
ATOM   1793 N N     . GLN A 1 230 ? -14.051 16.400  28.588  1.000 30.633 0 230 GLN A N     1 ? 
ATOM   1794 C CA    . GLN A 1 230 ? -14.180 15.252  27.638  1.000 37.243 0 230 GLN A CA    1 ? 
ATOM   1795 C C     . GLN A 1 230 ? -13.566 15.623  26.269  1.000 33.019 0 230 GLN A C     1 ? 
ATOM   1796 O O     . GLN A 1 230 ? -13.907 14.936  25.275  1.000 41.612 0 230 GLN A O     1 ? 
ATOM   1797 C CB    . GLN A 1 230 ? -15.645 14.810  27.492  1.000 38.417 0 230 GLN A CB    1 ? 
ATOM   1798 C CG    . GLN A 1 230 ? -16.256 14.254  28.773  1.000 40.982 0 230 GLN A CG    1 ? 
ATOM   1799 C CD    . GLN A 1 230 ? -17.545 13.494  28.533  1.000 47.529 0 230 GLN A CD    1 ? 
ATOM   1800 O OE1   . GLN A 1 230 ? -17.876 12.557  29.259  1.000 49.441 0 230 GLN A OE1   1 ? 
ATOM   1801 N NE2   . GLN A 1 230 ? -18.271 13.861  27.483  1.000 41.989 0 230 GLN A NE2   1 ? 
ATOM   1802 N N     . ASN A 1 231 ? -12.689 16.636  26.219  1.000 29.808 0 231 ASN A N     1 ? 
ATOM   1803 C CA    . ASN A 1 231 ? -11.896 17.017  25.012  1.000 29.854 0 231 ASN A CA    1 ? 
ATOM   1804 C C     . ASN A 1 231 ? -10.955 15.854  24.644  1.000 25.544 0 231 ASN A C     1 ? 
ATOM   1805 O O     . ASN A 1 231 ? -10.372 15.271  25.562  1.000 22.499 0 231 ASN A O     1 ? 
ATOM   1806 C CB    . ASN A 1 231 ? -11.114 18.300  25.263  1.000 33.846 0 231 ASN A CB    1 ? 
ATOM   1807 C CG    . ASN A 1 231 ? -11.218 19.278  24.117  1.000 42.228 0 231 ASN A CG    1 ? 
ATOM   1808 O OD1   . ASN A 1 231 ? -11.945 20.271  24.196  1.000 39.175 0 231 ASN A OD1   1 ? 
ATOM   1809 N ND2   . ASN A 1 231 ? -10.512 18.993  23.036  1.000 48.091 0 231 ASN A ND2   1 ? 
ATOM   1810 N N     . VAL A 1 232 ? -10.838 15.505  23.354  1.000 19.839 0 232 VAL A N     1 ? 
ATOM   1811 C CA    . VAL A 1 232 ? -10.133 14.263  22.920  1.000 19.116 0 232 VAL A CA    1 ? 
ATOM   1812 C C     . VAL A 1 232 ? -8.877  14.696  22.183  1.000 17.381 0 232 VAL A C     1 ? 
ATOM   1813 O O     . VAL A 1 232 ? -8.980  15.544  21.318  1.000 16.829 0 232 VAL A O     1 ? 
ATOM   1814 C CB    . VAL A 1 232 ? -11.013 13.357  22.034  1.000 22.710 0 232 VAL A CB    1 ? 
ATOM   1815 C CG1   . VAL A 1 232 ? -10.249 12.154  21.504  1.000 22.865 0 232 VAL A CG1   1 ? 
ATOM   1816 C CG2   . VAL A 1 232 ? -12.261 12.903  22.770  1.000 23.956 0 232 VAL A CG2   1 ? 
ATOM   1817 N N     . THR A 1 233 ? -7.749  14.090  22.523  1.000 17.465 0 233 THR A N     1 ? 
ATOM   1818 C CA    . THR A 1 233 ? -6.437  14.299  21.882  1.000 15.871 0 233 THR A CA    1 ? 
ATOM   1819 C C     . THR A 1 233 ? -5.925  12.916  21.494  1.000 15.197 0 233 THR A C     1 ? 
ATOM   1820 O O     . THR A 1 233 ? -6.099  11.982  22.277  1.000 15.662 0 233 THR A O     1 ? 
ATOM   1821 C CB    . THR A 1 233 ? -5.444  15.008  22.826  1.000 16.452 0 233 THR A CB    1 ? 
ATOM   1822 O OG1   . THR A 1 233 ? -5.496  14.278  24.052  1.000 21.457 0 233 THR A OG1   1 ? 
ATOM   1823 C CG2   . THR A 1 233 ? -5.775  16.454  23.077  1.000 19.466 0 233 THR A CG2   1 ? 
ATOM   1824 N N     . TYR A 1 234 ? -5.337  12.793  20.313  1.000 14.151 0 234 TYR A N     1 ? 
ATOM   1825 C CA    . TYR A 1 234 ? -4.750  11.535  19.820  1.000 12.292 0 234 TYR A CA    1 ? 
ATOM   1826 C C     . TYR A 1 234 ? -3.270  11.522  20.161  1.000 11.156 0 234 TYR A C     1 ? 
ATOM   1827 O O     . TYR A 1 234 ? -2.659  12.569  20.299  1.000 10.538 0 234 TYR A O     1 ? 
ATOM   1828 C CB    . TYR A 1 234 ? -5.054  11.358  18.325  1.000 12.789 0 234 TYR A CB    1 ? 
ATOM   1829 C CG    . TYR A 1 234 ? -6.484  10.939  18.100  1.000 12.524 0 234 TYR A CG    1 ? 
ATOM   1830 C CD1   . TYR A 1 234 ? -7.521  11.851  18.168  1.000 12.646 0 234 TYR A CD1   1 ? 
ATOM   1831 C CD2   . TYR A 1 234 ? -6.820  9.602   17.949  1.000 13.200 0 234 TYR A CD2   1 ? 
ATOM   1832 C CE1   . TYR A 1 234 ? -8.844  11.449  18.017  1.000 12.677 0 234 TYR A CE1   1 ? 
ATOM   1833 C CE2   . TYR A 1 234 ? -8.143  9.184   17.827  1.000 12.627 0 234 TYR A CE2   1 ? 
ATOM   1834 C CZ    . TYR A 1 234 ? -9.163  10.115  17.871  1.000 12.937 0 234 TYR A CZ    1 ? 
ATOM   1835 O OH    . TYR A 1 234 ? -10.479 9.718   17.700  1.000 14.114 0 234 TYR A OH    1 ? 
ATOM   1836 N N     . ASP A 1 235 ? -2.712  10.321  20.266  1.000 11.378 0 235 ASP A N     1 ? 
ATOM   1837 C CA    . ASP A 1 235 ? -1.275  10.107  20.536  1.000 11.623 0 235 ASP A CA    1 ? 
ATOM   1838 C C     . ASP A 1 235 ? -0.745  9.155   19.484  1.000 10.125 0 235 ASP A C     1 ? 
ATOM   1839 O O     . ASP A 1 235 ? -0.717  7.947   19.734  1.000 9.285  0 235 ASP A O     1 ? 
ATOM   1840 C CB    . ASP A 1 235 ? -1.054  9.600   21.952  1.000 13.912 0 235 ASP A CB    1 ? 
ATOM   1841 C CG    . ASP A 1 235 ? 0.408   9.544   22.364  1.000 14.655 0 235 ASP A CG    1 ? 
ATOM   1842 O OD1   . ASP A 1 235 ? 1.258   9.675   21.527  1.000 15.431 0 235 ASP A OD1   1 ? 
ATOM   1843 O OD2   . ASP A 1 235 ? 0.653   9.376   23.553  1.000 18.167 0 235 ASP A OD2   1 ? 
ATOM   1844 N N     . ASP A 1 236 ? -0.410  9.716   18.338  1.000 10.248 0 236 ASP A N     1 ? 
ATOM   1845 C CA    . ASP A 1 236 ? 0.119   8.974   17.185  1.000 10.499 0 236 ASP A CA    1 ? 
ATOM   1846 C C     . ASP A 1 236 ? 1.413   8.265   17.562  1.000 9.761  0 236 ASP A C     1 ? 
ATOM   1847 O O     . ASP A 1 236 ? 1.638   7.147   17.015  1.000 8.913  0 236 ASP A O     1 ? 
ATOM   1848 C CB    . ASP A 1 236 ? 0.307   9.902   15.997  1.000 10.416 0 236 ASP A CB    1 ? 
ATOM   1849 C CG    . ASP A 1 236 ? -0.975  10.414  15.385  1.000 10.309 0 236 ASP A CG    1 ? 
ATOM   1850 O OD1   . ASP A 1 236 ? -2.059  10.277  16.032  1.000 10.399 0 236 ASP A OD1   1 ? 
ATOM   1851 O OD2   . ASP A 1 236 ? -0.863  11.031  14.296  1.000 12.476 0 236 ASP A OD2   1 ? 
ATOM   1852 N N     . ARG A 1 237 ? 2.282   8.890   18.384  1.000 10.508 0 237 ARG A N     1 ? 
ATOM   1853 C CA    . ARG A 1 237 ? 3.575   8.262   18.755  1.000 10.499 0 237 ARG A CA    1 ? 
ATOM   1854 C C     . ARG A 1 237 ? 3.261   6.941   19.462  1.000 10.507 0 237 ARG A C     1 ? 
ATOM   1855 O O     . ARG A 1 237 ? 3.858   5.922   19.145  1.000 9.886  0 237 ARG A O     1 ? 
ATOM   1856 C CB    . ARG A 1 237 ? 4.435   9.183   19.617  1.000 10.981 0 237 ARG A CB    1 ? 
ATOM   1857 C CG    . ARG A 1 237 ? 5.847   8.686   19.875  1.000 10.983 0 237 ARG A CG    1 ? 
ATOM   1858 C CD    . ARG A 1 237 ? 6.420   9.213   21.185  1.000 11.899 0 237 ARG A CD    1 ? 
ATOM   1859 N NE    . ARG A 1 237 ? 5.570   8.846   22.273  1.000 12.965 0 237 ARG A NE    1 ? 
ATOM   1860 C CZ    . ARG A 1 237 ? 5.388   7.619   22.684  1.000 12.851 0 237 ARG A CZ    1 ? 
ATOM   1861 N NH1   . ARG A 1 237 ? 6.158   6.631   22.244  1.000 12.836 0 237 ARG A NH1   1 ? 
ATOM   1862 N NH2   . ARG A 1 237 ? 4.485   7.385   23.596  1.000 13.364 0 237 ARG A NH2   1 ? 
ATOM   1863 N N     . ASP A 1 238 ? 2.347   6.982   20.411  1.000 11.579 0 238 ASP A N     1 ? 
ATOM   1864 C CA    . ASP A 1 238 ? 1.949   5.812   21.218  1.000 12.435 0 238 ASP A CA    1 ? 
ATOM   1865 C C     . ASP A 1 238 ? 1.238   4.793   20.331  1.000 11.351 0 238 ASP A C     1 ? 
ATOM   1866 O O     . ASP A 1 238 ? 1.606   3.613   20.403  1.000 10.840 0 238 ASP A O     1 ? 
ATOM   1867 C CB    . ASP A 1 238 ? 1.154   6.258   22.441  1.000 13.332 0 238 ASP A CB    1 ? 
ATOM   1868 C CG    . ASP A 1 238 ? 0.748   5.079   23.293  1.000 15.004 0 238 ASP A CG    1 ? 
ATOM   1869 O OD1   . ASP A 1 238 ? 1.652   4.379   23.770  1.000 16.236 0 238 ASP A OD1   1 ? 
ATOM   1870 O OD2   . ASP A 1 238 ? -0.467  4.795   23.350  1.000 14.664 0 238 ASP A OD2   1 ? 
ATOM   1871 N N     . ALA A 1 239 ? 0.278   5.203   19.496  1.000 11.417 0 239 ALA A N     1 ? 
ATOM   1872 C CA    . ALA A 1 239 ? -0.406  4.250   18.585  1.000 11.196 0 239 ALA A CA    1 ? 
ATOM   1873 C C     . ALA A 1 239 ? 0.659   3.528   17.736  1.000 9.751  0 239 ALA A C     1 ? 
ATOM   1874 O O     . ALA A 1 239 ? 0.556   2.334   17.513  1.000 8.325  0 239 ALA A O     1 ? 
ATOM   1875 C CB    . ALA A 1 239 ? -1.407  4.958   17.718  1.000 10.905 0 239 ALA A CB    1 ? 
ATOM   1876 N N     . LEU A 1 240 ? 1.652   4.259   17.255  1.000 10.320 0 240 LEU A N     1 ? 
ATOM   1877 C CA    . LEU A 1 240 ? 2.718   3.688   16.381  1.000 11.764 0 240 LEU A CA    1 ? 
ATOM   1878 C C     . LEU A 1 240 ? 3.568   2.719   17.199  1.000 10.312 0 240 LEU A C     1 ? 
ATOM   1879 O O     . LEU A 1 240 ? 3.906   1.652   16.697  1.000 9.932  0 240 LEU A O     1 ? 
ATOM   1880 C CB    . LEU A 1 240 ? 3.603   4.797   15.821  1.000 13.919 0 240 LEU A CB    1 ? 
ATOM   1881 C CG    . LEU A 1 240 ? 3.301   5.304   14.420  1.000 18.474 0 240 LEU A CG    1 ? 
ATOM   1882 C CD1   . LEU A 1 240 ? 4.412   6.272   14.005  1.000 20.167 0 240 LEU A CD1   1 ? 
ATOM   1883 C CD2   . LEU A 1 240 ? 3.159   4.179   13.375  1.000 18.851 0 240 LEU A CD2   1 ? 
ATOM   1884 N N     . GLU A 1 241 ? 3.935   3.083   18.408  1.000 11.152 0 241 GLU A N     1 ? 
ATOM   1885 C CA    . GLU A 1 241 ? 4.760   2.223   19.277  1.000 11.397 0 241 GLU A CA    1 ? 
ATOM   1886 C C     . GLU A 1 241 ? 4.015   0.878   19.492  1.000 11.928 0 241 GLU A C     1 ? 
ATOM   1887 O O     . GLU A 1 241 ? 4.620   -0.195  19.315  1.000 10.420 0 241 GLU A O     1 ? 
ATOM   1888 C CB    . GLU A 1 241 ? 5.082   2.989   20.560  1.000 13.303 0 241 GLU A CB    1 ? 
ATOM   1889 C CG    . GLU A 1 241 ? 5.909   2.171   21.551  1.000 15.270 0 241 GLU A CG    1 ? 
ATOM   1890 C CD    . GLU A 1 241 ? 5.979   2.681   22.980  1.000 16.823 0 241 GLU A CD    1 ? 
ATOM   1891 O OE1   . GLU A 1 241 ? 5.903   3.885   23.200  1.000 16.268 0 241 GLU A OE1   1 ? 
ATOM   1892 O OE2   . GLU A 1 241 ? 6.075   1.854   23.865  1.000 19.878 0 241 GLU A OE2   1 ? 
ATOM   1893 N N     . GLN A 1 242 ? 2.733   0.922   19.867  1.000 12.815 0 242 GLN A N     1 ? 
ATOM   1894 C CA    . GLN A 1 242 ? 1.926   -0.309  20.117  1.000 13.322 0 242 GLN A CA    1 ? 
ATOM   1895 C C     . GLN A 1 242 ? 1.843   -1.131  18.815  1.000 12.605 0 242 GLN A C     1 ? 
ATOM   1896 O O     . GLN A 1 242 ? 2.022   -2.374  18.872  1.000 11.392 0 242 GLN A O     1 ? 
ATOM   1897 C CB    . GLN A 1 242 ? 0.525   0.056   20.590  1.000 15.978 0 242 GLN A CB    1 ? 
ATOM   1898 C CG    . GLN A 1 242 ? 0.461   0.727   21.959  1.000 19.269 0 242 GLN A CG    1 ? 
ATOM   1899 C CD    . GLN A 1 242 ? -0.984  0.775   22.425  1.000 25.089 0 242 GLN A CD    1 ? 
ATOM   1900 O OE1   . GLN A 1 242 ? -1.726  -0.228  22.369  1.000 29.212 0 242 GLN A OE1   1 ? 
ATOM   1901 N NE2   . GLN A 1 242 ? -1.447  1.970   22.771  1.000 27.971 0 242 GLN A NE2   1 ? 
ATOM   1902 N N     . PHE A 1 243 ? 1.557   -0.471  17.679  1.000 11.829 0 243 PHE A N     1 ? 
ATOM   1903 C CA    . PHE A 1 243 ? 1.416   -1.139  16.360  1.000 11.088 0 243 PHE A CA    1 ? 
ATOM   1904 C C     . PHE A 1 243 ? 2.752   -1.796  15.969  1.000 10.744 0 243 PHE A C     1 ? 
ATOM   1905 O O     . PHE A 1 243 ? 2.752   -3.025  15.589  1.000 9.617  0 243 PHE A O     1 ? 
ATOM   1906 C CB    . PHE A 1 243 ? 0.887   -0.149  15.321  1.000 11.035 0 243 PHE A CB    1 ? 
ATOM   1907 C CG    . PHE A 1 243 ? 0.823   -0.634  13.905  1.000 11.529 0 243 PHE A CG    1 ? 
ATOM   1908 C CD1   . PHE A 1 243 ? 0.496   -1.932  13.609  1.000 11.761 0 243 PHE A CD1   1 ? 
ATOM   1909 C CD2   . PHE A 1 243 ? 0.961   0.260   12.862  1.000 12.471 0 243 PHE A CD2   1 ? 
ATOM   1910 C CE1   . PHE A 1 243 ? 0.411   -2.375  12.294  1.000 13.169 0 243 PHE A CE1   1 ? 
ATOM   1911 C CE2   . PHE A 1 243 ? 0.841   -0.168  11.545  1.000 12.671 0 243 PHE A CE2   1 ? 
ATOM   1912 C CZ    . PHE A 1 243 ? 0.602   -1.494  11.263  1.000 13.133 0 243 PHE A CZ    1 ? 
ATOM   1913 N N     . VAL A 1 244 ? 3.865   -1.047  16.034  1.000 9.604  0 244 VAL A N     1 ? 
ATOM   1914 C CA    . VAL A 1 244 ? 5.195   -1.598  15.626  1.000 10.253 0 244 VAL A CA    1 ? 
ATOM   1915 C C     . VAL A 1 244 ? 5.548   -2.776  16.556  1.000 10.536 0 244 VAL A C     1 ? 
ATOM   1916 O O     . VAL A 1 244 ? 6.038   -3.802  16.073  1.000 10.245 0 244 VAL A O     1 ? 
ATOM   1917 C CB    . VAL A 1 244 ? 6.267   -0.496  15.590  1.000 10.326 0 244 VAL A CB    1 ? 
ATOM   1918 C CG1   . VAL A 1 244 ? 7.679   -1.050  15.448  1.000 11.318 0 244 VAL A CG1   1 ? 
ATOM   1919 C CG2   . VAL A 1 244 ? 5.966   0.495   14.482  1.000 10.754 0 244 VAL A CG2   1 ? 
ATOM   1920 N N     . GLN A 1 245 ? 5.353   -2.632  17.865  1.000 11.258 0 245 GLN A N     1 ? 
ATOM   1921 C CA    . GLN A 1 245 ? 5.679   -3.712  18.814  1.000 12.312 0 245 GLN A CA    1 ? 
ATOM   1922 C C     . GLN A 1 245 ? 4.827   -4.941  18.464  1.000 12.707 0 245 GLN A C     1 ? 
ATOM   1923 O O     . GLN A 1 245 ? 5.361   -6.042  18.496  1.000 10.362 0 245 GLN A O     1 ? 
ATOM   1924 C CB    . GLN A 1 245 ? 5.480   -3.274  20.269  1.000 13.419 0 245 GLN A CB    1 ? 
ATOM   1925 C CG    . GLN A 1 245 ? 5.759   -4.393  21.275  1.000 16.187 0 245 GLN A CG    1 ? 
ATOM   1926 C CD    . GLN A 1 245 ? 7.218   -4.754  21.254  1.000 17.525 0 245 GLN A CD    1 ? 
ATOM   1927 O OE1   . GLN A 1 245 ? 8.045   -3.969  21.680  1.000 23.044 0 245 GLN A OE1   1 ? 
ATOM   1928 N NE2   . GLN A 1 245 ? 7.558   -5.866  20.639  1.000 16.214 0 245 GLN A NE2   1 ? 
ATOM   1929 N N     . THR A 1 246 ? 3.552   -4.769  18.085  1.000 12.483 0 246 THR A N     1 ? 
ATOM   1930 C CA    . THR A 1 246 ? 2.659   -5.917  17.796  1.000 13.164 0 246 THR A CA    1 ? 
ATOM   1931 C C     . THR A 1 246 ? 3.148   -6.618  16.523  1.000 12.397 0 246 THR A C     1 ? 
ATOM   1932 O O     . THR A 1 246 ? 3.185   -7.859  16.479  1.000 9.443  0 246 THR A O     1 ? 
ATOM   1933 C CB    . THR A 1 246 ? 1.180   -5.505  17.749  1.000 14.395 0 246 THR A CB    1 ? 
ATOM   1934 O OG1   . THR A 1 246 ? 0.832   -4.964  19.017  1.000 14.263 0 246 THR A OG1   1 ? 
ATOM   1935 C CG2   . THR A 1 246 ? 0.268   -6.660  17.416  1.000 14.725 0 246 THR A CG2   1 ? 
ATOM   1936 N N     . MET A 1 247 ? 3.561   -5.850  15.524  1.000 11.019 0 247 MET A N     1 ? 
ATOM   1937 C CA    . MET A 1 247 ? 4.162   -6.406  14.299  1.000 11.750 0 247 MET A CA    1 ? 
ATOM   1938 C C     . MET A 1 247 ? 5.432   -7.197  14.649  1.000 10.976 0 247 MET A C     1 ? 
ATOM   1939 O O     . MET A 1 247 ? 5.532   -8.344  14.213  1.000 11.107 0 247 MET A O     1 ? 
ATOM   1940 C CB    . MET A 1 247 ? 4.500   -5.285  13.315  1.000 13.138 0 247 MET A CB    1 ? 
ATOM   1941 C CG    . MET A 1 247 ? 3.320   -4.900  12.435  1.000 15.275 0 247 MET A CG    1 ? 
ATOM   1942 S SD    . MET A 1 247 ? 3.851   -3.612  11.261  1.000 17.931 0 247 MET A SD    1 ? 
ATOM   1943 C CE    . MET A 1 247 ? 4.796   -4.555  10.096  1.000 20.728 0 247 MET A CE    1 ? 
ATOM   1944 N N     . LEU A 1 248 ? 6.331   -6.643  15.452  1.000 11.286 0 248 LEU A N     1 ? 
ATOM   1945 C CA    . LEU A 1 248 ? 7.567   -7.345  15.892  1.000 12.344 0 248 LEU A CA    1 ? 
ATOM   1946 C C     . LEU A 1 248 ? 7.207   -8.665  16.593  1.000 13.093 0 248 LEU A C     1 ? 
ATOM   1947 O O     . LEU A 1 248 ? 7.858   -9.690  16.282  1.000 12.967 0 248 LEU A O     1 ? 
ATOM   1948 C CB    . LEU A 1 248 ? 8.376   -6.423  16.793  1.000 11.977 0 248 LEU A CB    1 ? 
ATOM   1949 C CG    . LEU A 1 248 ? 9.161   -5.343  16.034  1.000 12.132 0 248 LEU A CG    1 ? 
ATOM   1950 C CD1   . LEU A 1 248 ? 9.654   -4.273  16.973  1.000 13.841 0 248 LEU A CD1   1 ? 
ATOM   1951 C CD2   . LEU A 1 248 ? 10.324  -5.976  15.284  1.000 12.861 0 248 LEU A CD2   1 ? 
ATOM   1952 N N     . ASP A 1 249 ? 6.179   -8.651  17.432  1.000 14.821 0 249 ASP A N     1 ? 
ATOM   1953 C CA    . ASP A 1 249 ? 5.732   -9.843  18.202  1.000 17.999 0 249 ASP A CA    1 ? 
ATOM   1954 C C     . ASP A 1 249 ? 5.240   -10.941 17.265  1.000 17.318 0 249 ASP A C     1 ? 
ATOM   1955 O O     . ASP A 1 249 ? 5.123   -12.101 17.718  1.000 18.357 0 249 ASP A O     1 ? 
ATOM   1956 C CB    . ASP A 1 249 ? 4.614   -9.483  19.182  1.000 18.917 0 249 ASP A CB    1 ? 
ATOM   1957 C CG    . ASP A 1 249 ? 5.057   -8.617  20.340  1.000 19.969 0 249 ASP A CG    1 ? 
ATOM   1958 O OD1   . ASP A 1 249 ? 6.268   -8.410  20.514  1.000 19.553 0 249 ASP A OD1   1 ? 
ATOM   1959 O OD2   . ASP A 1 249 ? 4.174   -8.096  20.996  1.000 21.782 0 249 ASP A OD2   1 ? 
ATOM   1960 N N     . ASN A 1 250 ? 4.898   -10.618 16.022  1.000 14.755 0 250 ASN A N     1 ? 
ATOM   1961 C CA    . ASN A 1 250 ? 4.309   -11.611 15.108  1.000 14.447 0 250 ASN A CA    1 ? 
ATOM   1962 C C     . ASN A 1 250 ? 5.344   -12.141 14.118  1.000 13.576 0 250 ASN A C     1 ? 
ATOM   1963 O O     . ASN A 1 250 ? 4.960   -12.903 13.258  1.000 15.040 0 250 ASN A O     1 ? 
ATOM   1964 C CB    . ASN A 1 250 ? 3.085   -11.049 14.419  1.000 14.486 0 250 ASN A CB    1 ? 
ATOM   1965 C CG    . ASN A 1 250 ? 1.868   -11.120 15.306  1.000 16.309 0 250 ASN A CG    1 ? 
ATOM   1966 O OD1   . ASN A 1 250 ? 1.186   -12.160 15.349  1.000 16.839 0 250 ASN A OD1   1 ? 
ATOM   1967 N ND2   . ASN A 1 250 ? 1.594   -10.036 16.023  1.000 16.401 0 250 ASN A ND2   1 ? 
ATOM   1968 N N     . PHE A 1 251 ? 6.608   -11.730 14.217  1.000 13.727 0 251 PHE A N     1 ? 
ATOM   1969 C CA    . PHE A 1 251 ? 7.689   -12.371 13.456  1.000 12.970 0 251 PHE A CA    1 ? 
ATOM   1970 C C     . PHE A 1 251 ? 7.897   -13.753 14.106  1.000 15.175 0 251 PHE A C     1 ? 
ATOM   1971 O O     . PHE A 1 251 ? 7.840   -13.836 15.362  1.000 15.544 0 251 PHE A O     1 ? 
ATOM   1972 C CB    . PHE A 1 251 ? 8.966   -11.551 13.455  1.000 12.959 0 251 PHE A CB    1 ? 
ATOM   1973 C CG    . PHE A 1 251 ? 9.009   -10.412 12.461  1.000 13.476 0 251 PHE A CG    1 ? 
ATOM   1974 C CD1   . PHE A 1 251 ? 8.370   -9.213  12.726  1.000 13.389 0 251 PHE A CD1   1 ? 
ATOM   1975 C CD2   . PHE A 1 251 ? 9.739   -10.530 11.281  1.000 12.991 0 251 PHE A CD2   1 ? 
ATOM   1976 C CE1   . PHE A 1 251 ? 8.484   -8.142  11.832  1.000 13.092 0 251 PHE A CE1   1 ? 
ATOM   1977 C CE2   . PHE A 1 251 ? 9.864   -9.466  10.406  1.000 13.457 0 251 PHE A CE2   1 ? 
ATOM   1978 C CZ    . PHE A 1 251 ? 9.195   -8.284  10.661  1.000 14.206 0 251 PHE A CZ    1 ? 
ATOM   1979 N N     . HIS A 1 252 ? 8.110   -14.775 13.293  1.000 15.310 0 252 HIS A N     1 ? 
ATOM   1980 C CA    . HIS A 1 252 ? 8.480   -16.140 13.741  1.000 16.271 0 252 HIS A CA    1 ? 
ATOM   1981 C C     . HIS A 1 252 ? 9.753   -16.579 13.029  1.000 15.161 0 252 HIS A C     1 ? 
ATOM   1982 O O     . HIS A 1 252 ? 9.823   -16.458 11.815  1.000 12.395 0 252 HIS A O     1 ? 
ATOM   1983 C CB    . HIS A 1 252 ? 7.334   -17.117 13.482  1.000 17.938 0 252 HIS A CB    1 ? 
ATOM   1984 C CG    . HIS A 1 252 ? 6.046   -16.628 14.039  1.000 22.148 0 252 HIS A CG    1 ? 
ATOM   1985 N ND1   . HIS A 1 252 ? 5.848   -16.452 15.403  1.000 25.351 0 252 HIS A ND1   1 ? 
ATOM   1986 C CD2   . HIS A 1 252 ? 4.920   -16.186 13.435  1.000 22.964 0 252 HIS A CD2   1 ? 
ATOM   1987 C CE1   . HIS A 1 252 ? 4.640   -15.948 15.605  1.000 24.355 0 252 HIS A CE1   1 ? 
ATOM   1988 N NE2   . HIS A 1 252 ? 4.054   -15.783 14.426  1.000 22.097 0 252 HIS A NE2   1 ? 
ATOM   1989 N N     . ASP A 1 253 ? 10.689  -17.119 13.779  1.000 16.147 0 253 ASP A N     1 ? 
ATOM   1990 C CA    . ASP A 1 253 ? 11.926  -17.748 13.253  1.000 18.178 0 253 ASP A CA    1 ? 
ATOM   1991 C C     . ASP A 1 253 ? 11.501  -18.919 12.390  1.000 17.159 0 253 ASP A C     1 ? 
ATOM   1992 O O     . ASP A 1 253 ? 10.678  -19.733 12.859  1.000 17.112 0 253 ASP A O     1 ? 
ATOM   1993 C CB    . ASP A 1 253 ? 12.888  -18.153 14.384  1.000 20.657 0 253 ASP A CB    1 ? 
ATOM   1994 C CG    . ASP A 1 253 ? 13.508  -16.966 15.103  1.000 25.952 0 253 ASP A CG    1 ? 
ATOM   1995 O OD1   . ASP A 1 253 ? 13.444  -15.835 14.540  1.000 24.547 0 253 ASP A OD1   1 ? 
ATOM   1996 O OD2   . ASP A 1 253 ? 14.080  -17.179 16.212  1.000 32.497 0 253 ASP A OD2   1 ? 
ATOM   1997 N N     . THR A 1 254 ? 11.975  -18.957 11.150  1.000 15.404 0 254 THR A N     1 ? 
ATOM   1998 C CA    . THR A 1 254 ? 11.503  -19.903 10.113  1.000 16.119 0 254 THR A CA    1 ? 
ATOM   1999 C C     . THR A 1 254 ? 12.714  -20.613 9.552   1.000 14.930 0 254 THR A C     1 ? 
ATOM   2000 O O     . THR A 1 254 ? 13.545  -19.964 8.921   1.000 12.685 0 254 THR A O     1 ? 
ATOM   2001 C CB    . THR A 1 254 ? 10.727  -19.217 8.986   1.000 16.098 0 254 THR A CB    1 ? 
ATOM   2002 O OG1   . THR A 1 254 ? 9.679   -18.461 9.601   1.000 18.099 0 254 THR A OG1   1 ? 
ATOM   2003 C CG2   . THR A 1 254 ? 10.172  -20.192 7.979   1.000 15.810 0 254 THR A CG2   1 ? 
ATOM   2004 N N     . TRP A 1 255 ? 12.743  -21.927 9.701   1.000 12.721 0 255 TRP A N     1 ? 
ATOM   2005 C CA    . TRP A 1 255 ? 13.875  -22.747 9.231   1.000 14.186 0 255 TRP A CA    1 ? 
ATOM   2006 C C     . TRP A 1 255 ? 13.953  -22.690 7.708   1.000 14.040 0 255 TRP A C     1 ? 
ATOM   2007 O O     . TRP A 1 255 ? 12.913  -22.808 7.042   1.000 15.518 0 255 TRP A O     1 ? 
ATOM   2008 C CB    . TRP A 1 255 ? 13.730  -24.185 9.730   1.000 14.268 0 255 TRP A CB    1 ? 
ATOM   2009 C CG    . TRP A 1 255 ? 14.858  -25.084 9.321   1.000 14.487 0 255 TRP A CG    1 ? 
ATOM   2010 C CD1   . TRP A 1 255 ? 14.805  -26.151 8.483   1.000 16.227 0 255 TRP A CD1   1 ? 
ATOM   2011 C CD2   . TRP A 1 255 ? 16.176  -25.092 9.878   1.000 15.581 0 255 TRP A CD2   1 ? 
ATOM   2012 N NE1   . TRP A 1 255 ? 16.028  -26.781 8.422   1.000 15.926 0 255 TRP A NE1   1 ? 
ATOM   2013 C CE2   . TRP A 1 255 ? 16.880  -26.172 9.287   1.000 16.564 0 255 TRP A CE2   1 ? 
ATOM   2014 C CE3   . TRP A 1 255 ? 16.839  -24.286 10.807  1.000 16.817 0 255 TRP A CE3   1 ? 
ATOM   2015 C CZ2   . TRP A 1 255 ? 18.222  -26.432 9.564   1.000 16.386 0 255 TRP A CZ2   1 ? 
ATOM   2016 C CZ3   . TRP A 1 255 ? 18.147  -24.579 11.125  1.000 18.342 0 255 TRP A CZ3   1 ? 
ATOM   2017 C CH2   . TRP A 1 255 ? 18.831  -25.638 10.508  1.000 18.297 0 255 TRP A CH2   1 ? 
ATOM   2018 N N     . ASP A 1 256 ? 15.167  -22.568 7.195   1.000 15.333 0 256 ASP A N     1 ? 
ATOM   2019 C CA    . ASP A 1 256 ? 15.495  -22.641 5.763   1.000 16.724 0 256 ASP A CA    1 ? 
ATOM   2020 C C     . ASP A 1 256 ? 16.475  -23.788 5.568   1.000 15.886 0 256 ASP A C     1 ? 
ATOM   2021 O O     . ASP A 1 256 ? 17.635  -23.671 6.039   1.000 14.408 0 256 ASP A O     1 ? 
ATOM   2022 C CB    . ASP A 1 256 ? 16.104  -21.346 5.232   1.000 18.681 0 256 ASP A CB    1 ? 
ATOM   2023 C CG    . ASP A 1 256 ? 16.302  -21.435 3.740   1.000 22.364 0 256 ASP A CG    1 ? 
ATOM   2024 O OD1   . ASP A 1 256 ? 17.449  -21.758 3.308   1.000 22.932 0 256 ASP A OD1   1 ? 
ATOM   2025 O OD2   . ASP A 1 256 ? 15.272  -21.392 3.035   1.000 27.756 0 256 ASP A OD2   1 ? 
ATOM   2026 N N     . SER A 1 257 ? 16.037  -24.839 4.896   1.000 17.705 0 257 SER A N     1 ? 
ATOM   2027 C CA    . SER A 1 257 ? 16.808  -26.104 4.752   1.000 19.697 0 257 SER A CA    1 ? 
ATOM   2028 C C     . SER A 1 257 ? 18.062  -25.857 3.885   1.000 21.476 0 257 SER A C     1 ? 
ATOM   2029 O O     . SER A 1 257 ? 19.109  -26.388 4.213   1.000 21.305 0 257 SER A O     1 ? 
ATOM   2030 C CB    . SER A 1 257 ? 15.951  -27.164 4.180   1.000 18.270 0 257 SER A CB    1 ? 
ATOM   2031 O OG    . SER A 1 257 ? 15.531  -26.809 2.883   1.000 20.391 0 257 SER A OG    1 ? 
ATOM   2032 N N     . LYS A 1 258 ? 17.979  -25.006 2.857   1.000 25.506 0 258 LYS A N     1 ? 
ATOM   2033 C CA    . LYS A 1 258 ? 19.155  -24.660 1.998   1.000 28.502 0 258 LYS A CA    1 ? 
ATOM   2034 C C     . LYS A 1 258 ? 20.267  -23.988 2.827   1.000 29.962 0 258 LYS A C     1 ? 
ATOM   2035 O O     . LYS A 1 258 ? 21.439  -24.395 2.705   1.000 27.058 0 258 LYS A O     1 ? 
ATOM   2036 C CB    . LYS A 1 258 ? 18.742  -23.753 0.834   1.000 34.777 0 258 LYS A CB    1 ? 
ATOM   2037 C CG    . LYS A 1 258 ? 19.819  -23.574 -0.240  1.000 43.906 0 258 LYS A CG    1 ? 
ATOM   2038 C CD    . LYS A 1 258 ? 20.113  -24.839 -1.030  1.000 47.791 0 258 LYS A CD    1 ? 
ATOM   2039 C CE    . LYS A 1 258 ? 18.927  -25.296 -1.856  1.000 52.895 0 258 LYS A CE    1 ? 
ATOM   2040 N NZ    . LYS A 1 258 ? 19.110  -26.676 -2.357  1.000 56.646 0 258 LYS A NZ    1 ? 
ATOM   2041 N N     . ASP A 1 259 ? 19.928  -22.987 3.638   1.000 25.625 0 259 ASP A N     1 ? 
ATOM   2042 C CA    . ASP A 1 259 ? 20.912  -22.130 4.331   1.000 25.930 0 259 ASP A CA    1 ? 
ATOM   2043 C C     . ASP A 1 259 ? 21.299  -22.741 5.672   1.000 22.429 0 259 ASP A C     1 ? 
ATOM   2044 O O     . ASP A 1 259 ? 22.255  -22.244 6.274   1.000 19.739 0 259 ASP A O     1 ? 
ATOM   2045 C CB    . ASP A 1 259 ? 20.380  -20.701 4.479   1.000 26.144 0 259 ASP A CB    1 ? 
ATOM   2046 C CG    . ASP A 1 259 ? 20.273  -19.984 3.143   1.000 29.072 0 259 ASP A CG    1 ? 
ATOM   2047 O OD1   . ASP A 1 259 ? 20.600  -20.617 2.116   1.000 28.942 0 259 ASP A OD1   1 ? 
ATOM   2048 O OD2   . ASP A 1 259 ? 19.836  -18.800 3.133   1.000 29.721 0 259 ASP A OD2   1 ? 
ATOM   2049 N N     . GLN A 1 260 ? 20.541  -23.741 6.145   1.000 21.884 0 260 GLN A N     1 ? 
ATOM   2050 C CA    . GLN A 1 260 ? 20.774  -24.425 7.437   1.000 21.038 0 260 GLN A CA    1 ? 
ATOM   2051 C C     . GLN A 1 260 ? 20.753  -23.409 8.559   1.000 18.487 0 260 GLN A C     1 ? 
ATOM   2052 O O     . GLN A 1 260 ? 21.579  -23.514 9.485   1.000 18.256 0 260 GLN A O     1 ? 
ATOM   2053 C CB    . GLN A 1 260 ? 22.097  -25.208 7.420   1.000 24.161 0 260 GLN A CB    1 ? 
ATOM   2054 C CG    . GLN A 1 260 ? 22.011  -26.441 6.542   1.000 25.321 0 260 GLN A CG    1 ? 
ATOM   2055 C CD    . GLN A 1 260 ? 21.106  -27.473 7.171   1.000 23.579 0 260 GLN A CD    1 ? 
ATOM   2056 O OE1   . GLN A 1 260 ? 21.423  -28.045 8.214   1.000 22.705 0 260 GLN A OE1   1 ? 
ATOM   2057 N NE2   . GLN A 1 260 ? 19.967  -27.708 6.538   1.000 24.739 0 260 GLN A NE2   1 ? 
ATOM   2058 N N     . ARG A 1 261 ? 19.796  -22.479 8.521   1.000 16.310 0 261 ARG A N     1 ? 
ATOM   2059 C CA    . ARG A 1 261 ? 19.558  -21.559 9.641   1.000 15.214 0 261 ARG A CA    1 ? 
ATOM   2060 C C     . ARG A 1 261 ? 18.117  -21.078 9.586   1.000 14.424 0 261 ARG A C     1 ? 
ATOM   2061 O O     . ARG A 1 261 ? 17.442  -21.370 8.621   1.000 12.676 0 261 ARG A O     1 ? 
ATOM   2062 C CB    . ARG A 1 261 ? 20.512  -20.358 9.523   1.000 16.017 0 261 ARG A CB    1 ? 
ATOM   2063 C CG    . ARG A 1 261 ? 20.382  -19.630 8.190   1.000 15.862 0 261 ARG A CG    1 ? 
ATOM   2064 C CD    . ARG A 1 261 ? 21.000  -18.226 8.253   1.000 17.358 0 261 ARG A CD    1 ? 
ATOM   2065 N NE    . ARG A 1 261 ? 20.216  -17.345 9.085   1.000 18.181 0 261 ARG A NE    1 ? 
ATOM   2066 C CZ    . ARG A 1 261 ? 20.484  -16.051 9.303   1.000 20.861 0 261 ARG A CZ    1 ? 
ATOM   2067 N NH1   . ARG A 1 261 ? 21.539  -15.483 8.739   1.000 20.717 0 261 ARG A NH1   1 ? 
ATOM   2068 N NH2   . ARG A 1 261 ? 19.672  -15.329 10.047  1.000 19.471 0 261 ARG A NH2   1 ? 
ATOM   2069 N N     . SER A 1 262 ? 17.698  -20.293 10.562  1.000 14.450 0 262 SER A N     1 ? 
ATOM   2070 C CA    . SER A 1 262 ? 16.335  -19.727 10.588  1.000 15.414 0 262 SER A CA    1 ? 
ATOM   2071 C C     . SER A 1 262 ? 16.424  -18.261 10.156  1.000 16.062 0 262 SER A C     1 ? 
ATOM   2072 O O     . SER A 1 262 ? 17.523  -17.664 10.293  1.000 14.208 0 262 SER A O     1 ? 
ATOM   2073 C CB    . SER A 1 262 ? 15.703  -19.898 11.911  1.000 15.713 0 262 SER A CB    1 ? 
ATOM   2074 O OG    . SER A 1 262 ? 15.512  -21.300 12.170  1.000 18.058 0 262 SER A OG    1 ? 
ATOM   2075 N N     . TYR A 1 263 ? 15.343  -17.750 9.566   1.000 14.256 0 263 TYR A N     1 ? 
ATOM   2076 C CA    . TYR A 1 263 ? 15.137  -16.294 9.346   1.000 14.252 0 263 TYR A CA    1 ? 
ATOM   2077 C C     . TYR A 1 263 ? 13.832  -15.912 9.992   1.000 14.728 0 263 TYR A C     1 ? 
ATOM   2078 O O     . TYR A 1 263 ? 12.889  -16.692 9.961   1.000 13.974 0 263 TYR A O     1 ? 
ATOM   2079 C CB    . TYR A 1 263 ? 15.109  -15.938 7.860   1.000 14.272 0 263 TYR A CB    1 ? 
ATOM   2080 C CG    . TYR A 1 263 ? 16.381  -16.284 7.129   1.000 15.317 0 263 TYR A CG    1 ? 
ATOM   2081 C CD1   . TYR A 1 263 ? 17.446  -15.416 7.110   1.000 16.717 0 263 TYR A CD1   1 ? 
ATOM   2082 C CD2   . TYR A 1 263 ? 16.505  -17.483 6.435   1.000 16.661 0 263 TYR A CD2   1 ? 
ATOM   2083 C CE1   . TYR A 1 263 ? 18.598  -15.698 6.395   1.000 17.873 0 263 TYR A CE1   1 ? 
ATOM   2084 C CE2   . TYR A 1 263 ? 17.657  -17.797 5.731   1.000 17.908 0 263 TYR A CE2   1 ? 
ATOM   2085 C CZ    . TYR A 1 263 ? 18.716  -16.903 5.727   1.000 19.441 0 263 TYR A CZ    1 ? 
ATOM   2086 O OH    . TYR A 1 263 ? 19.873  -17.207 5.076   1.000 21.484 0 263 TYR A OH    1 ? 
ATOM   2087 N N     . PRO A 1 264 ? 13.748  -14.692 10.557  1.000 15.642 0 264 PRO A N     1 ? 
ATOM   2088 C CA    . PRO A 1 264 ? 12.507  -14.199 11.133  1.000 15.735 0 264 PRO A CA    1 ? 
ATOM   2089 C C     . PRO A 1 264 ? 11.553  -13.841 9.993   1.000 16.761 0 264 PRO A C     1 ? 
ATOM   2090 O O     . PRO A 1 264 ? 11.988  -13.169 9.092   1.000 24.530 0 264 PRO A O     1 ? 
ATOM   2091 C CB    . PRO A 1 264 ? 12.951  -12.980 11.930  1.000 16.087 0 264 PRO A CB    1 ? 
ATOM   2092 C CG    . PRO A 1 264 ? 14.203  -12.501 11.269  1.000 16.458 0 264 PRO A CG    1 ? 
ATOM   2093 C CD    . PRO A 1 264 ? 14.825  -13.691 10.560  1.000 16.334 0 264 PRO A CD    1 ? 
ATOM   2094 N N     . ARG A 1 265 ? 10.318  -14.321 10.012  1.000 14.535 0 265 ARG A N     1 ? 
ATOM   2095 C CA    . ARG A 1 265 ? 9.331   -14.006 8.957   1.000 14.053 0 265 ARG A CA    1 ? 
ATOM   2096 C C     . ARG A 1 265 ? 8.073   -13.447 9.609   1.000 14.105 0 265 ARG A C     1 ? 
ATOM   2097 O O     . ARG A 1 265 ? 7.580   -14.070 10.580  1.000 12.327 0 265 ARG A O     1 ? 
ATOM   2098 C CB    . ARG A 1 265 ? 8.985   -15.244 8.123   1.000 16.326 0 265 ARG A CB    1 ? 
ATOM   2099 C CG    . ARG A 1 265 ? 10.120  -15.743 7.248   1.000 17.805 0 265 ARG A CG    1 ? 
ATOM   2100 C CD    . ARG A 1 265 ? 9.649   -16.586 6.078   1.000 18.238 0 265 ARG A CD    1 ? 
ATOM   2101 N NE    . ARG A 1 265 ? 8.900   -15.759 5.186   1.000 16.844 0 265 ARG A NE    1 ? 
ATOM   2102 C CZ    . ARG A 1 265 ? 9.387   -15.068 4.182   1.000 16.963 0 265 ARG A CZ    1 ? 
ATOM   2103 N NH1   . ARG A 1 265 ? 10.669  -15.158 3.852   1.000 15.660 0 265 ARG A NH1   1 ? 
ATOM   2104 N NH2   . ARG A 1 265 ? 8.574   -14.255 3.509   1.000 16.148 0 265 ARG A NH2   1 ? 
ATOM   2105 N N     . LEU A 1 266 ? 7.570   -12.336 9.049   1.000 11.956 0 266 LEU A N     1 ? 
ATOM   2106 C CA    . LEU A 1 266 ? 6.227   -11.797 9.322   1.000 12.307 0 266 LEU A CA    1 ? 
ATOM   2107 C C     . LEU A 1 266 ? 5.300   -12.229 8.196   1.000 12.046 0 266 LEU A C     1 ? 
ATOM   2108 O O     . LEU A 1 266 ? 5.603   -11.913 7.022   1.000 13.558 0 266 LEU A O     1 ? 
ATOM   2109 C CB    . LEU A 1 266 ? 6.310   -10.270 9.417   1.000 11.775 0 266 LEU A CB    1 ? 
ATOM   2110 C CG    . LEU A 1 266 ? 5.009   -9.585  9.791   1.000 11.982 0 266 LEU A CG    1 ? 
ATOM   2111 C CD1   . LEU A 1 266 ? 4.558   -9.965  11.191  1.000 12.401 0 266 LEU A CD1   1 ? 
ATOM   2112 C CD2   . LEU A 1 266 ? 5.181   -8.061  9.669   1.000 13.125 0 266 LEU A CD2   1 ? 
ATOM   2113 N N     . THR A 1 267 ? 4.294   -13.039 8.541   1.000 11.868 0 267 THR A N     1 ? 
ATOM   2114 C CA    . THR A 1 267 ? 3.198   -13.484 7.666   1.000 13.261 0 267 THR A CA    1 ? 
ATOM   2115 C C     . THR A 1 267 ? 2.009   -12.544 7.876   1.000 14.191 0 267 THR A C     1 ? 
ATOM   2116 O O     . THR A 1 267 ? 1.554   -12.375 9.043   1.000 14.007 0 267 THR A O     1 ? 
ATOM   2117 C CB    . THR A 1 267 ? 2.799   -14.946 7.953   1.000 14.042 0 267 THR A CB    1 ? 
ATOM   2118 O OG1   . THR A 1 267 ? 3.952   -15.719 7.659   1.000 15.461 0 267 THR A OG1   1 ? 
ATOM   2119 C CG2   . THR A 1 267 ? 1.684   -15.435 7.068   1.000 15.540 0 267 THR A CG2   1 ? 
ATOM   2120 N N     . VAL A 1 268 ? 1.573   -11.895 6.813   1.000 13.696 0 268 VAL A N     1 ? 
ATOM   2121 C CA    . VAL A 1 268 ? 0.381   -11.004 6.872   1.000 15.330 0 268 VAL A CA    1 ? 
ATOM   2122 C C     . VAL A 1 268 ? -0.579  -11.438 5.772   1.000 14.935 0 268 VAL A C     1 ? 
ATOM   2123 O O     . VAL A 1 268 ? -0.351  -11.041 4.609   1.000 15.437 0 268 VAL A O     1 ? 
ATOM   2124 C CB    . VAL A 1 268 ? 0.748   -9.521  6.760   1.000 16.414 0 268 VAL A CB    1 ? 
ATOM   2125 C CG1   . VAL A 1 268 ? -0.498  -8.654  6.919   1.000 18.007 0 268 VAL A CG1   1 ? 
ATOM   2126 C CG2   . VAL A 1 268 ? 1.797   -9.101  7.766   1.000 18.697 0 268 VAL A CG2   1 ? 
ATOM   2127 N N     . GLU A 1 269 ? -1.624  -12.165 6.163   1.000 16.144 0 269 GLU A N     1 ? 
ATOM   2128 C CA    . GLU A 1 269 ? -2.703  -12.639 5.255   1.000 18.550 0 269 GLU A CA    1 ? 
ATOM   2129 C C     . GLU A 1 269 ? -3.558  -11.451 4.840   1.000 15.416 0 269 GLU A C     1 ? 
ATOM   2130 O O     . GLU A 1 269 ? -3.895  -10.647 5.681   1.000 12.934 0 269 GLU A O     1 ? 
ATOM   2131 C CB    . GLU A 1 269 ? -3.566  -13.691 5.948   1.000 23.337 0 269 GLU A CB    1 ? 
ATOM   2132 C CG    . GLU A 1 269 ? -2.782  -14.925 6.310   1.000 29.215 0 269 GLU A CG    1 ? 
ATOM   2133 C CD    . GLU A 1 269 ? -3.619  -16.164 6.586   1.000 34.834 0 269 GLU A CD    1 ? 
ATOM   2134 O OE1   . GLU A 1 269 ? -4.856  -16.035 6.706   1.000 35.966 0 269 GLU A OE1   1 ? 
ATOM   2135 O OE2   . GLU A 1 269 ? -3.023  -17.250 6.676   1.000 43.819 0 269 GLU A OE2   1 ? 
ATOM   2136 N N     . LEU A 1 270 ? -3.882  -11.356 3.567   1.000 14.193 0 270 LEU A N     1 ? 
ATOM   2137 C CA    . LEU A 1 270 ? -4.955  -10.464 3.114   1.000 15.219 0 270 LEU A CA    1 ? 
ATOM   2138 C C     . LEU A 1 270 ? -6.219  -10.922 3.840   1.000 13.512 0 270 LEU A C     1 ? 
ATOM   2139 O O     . LEU A 1 270 ? -6.413  -12.120 4.013   1.000 11.581 0 270 LEU A O     1 ? 
ATOM   2140 C CB    . LEU A 1 270 ? -5.053  -10.597 1.584   1.000 16.482 0 270 LEU A CB    1 ? 
ATOM   2141 C CG    . LEU A 1 270 ? -5.661  -9.403  0.872   1.000 20.000 0 270 LEU A CG    1 ? 
ATOM   2142 C CD1   . LEU A 1 270 ? -4.784  -8.155  1.021   1.000 18.920 0 270 LEU A CD1   1 ? 
ATOM   2143 C CD2   . LEU A 1 270 ? -5.896  -9.731  -0.607  1.000 21.035 0 270 LEU A CD2   1 ? 
ATOM   2144 N N     . PRO A 1 271 ? -7.084  -10.019 4.357   1.000 14.093 0 271 PRO A N     1 ? 
ATOM   2145 C CA    . PRO A 1 271 ? -8.304  -10.473 5.044   1.000 14.243 0 271 PRO A CA    1 ? 
ATOM   2146 C C     . PRO A 1 271 ? -9.479  -10.825 4.125   1.000 16.000 0 271 PRO A C     1 ? 
ATOM   2147 O O     . PRO A 1 271 ? -10.593 -11.062 4.640   1.000 16.802 0 271 PRO A O     1 ? 
ATOM   2148 C CB    . PRO A 1 271 ? -8.662  -9.260  5.902   1.000 14.200 0 271 PRO A CB    1 ? 
ATOM   2149 C CG    . PRO A 1 271 ? -8.196  -8.080  5.043   1.000 14.038 0 271 PRO A CG    1 ? 
ATOM   2150 C CD    . PRO A 1 271 ? -6.892  -8.548  4.421   1.000 13.980 0 271 PRO A CD    1 ? 
ATOM   2151 N N     . VAL A 1 272 ? -9.258  -10.798 2.814   1.000 15.201 0 272 VAL A N     1 ? 
ATOM   2152 C CA    . VAL A 1 272 ? -10.253 -11.191 1.785   1.000 15.157 0 272 VAL A CA    1 ? 
ATOM   2153 C C     . VAL A 1 272 ? -9.559  -12.114 0.784   1.000 16.709 0 272 VAL A C     1 ? 
ATOM   2154 O O     . VAL A 1 272 ? -8.287  -12.258 0.816   1.000 15.029 0 272 VAL A O     1 ? 
ATOM   2155 C CB    . VAL A 1 272 ? -10.869 -9.947  1.096   1.000 15.947 0 272 VAL A CB    1 ? 
ATOM   2156 C CG1   . VAL A 1 272 ? -11.603 -9.051  2.104   1.000 16.813 0 272 VAL A CG1   1 ? 
ATOM   2157 C CG2   . VAL A 1 272 ? -9.823  -9.157  0.327   1.000 15.652 0 272 VAL A CG2   1 ? 
ATOM   2158 N N     . GLN A 1 273 ? -10.339 -12.709 -0.118  1.000 16.557 0 273 GLN A N     1 ? 
ATOM   2159 C CA    . GLN A 1 273 ? -9.787  -13.608 -1.156  1.000 16.661 0 273 GLN A CA    1 ? 
ATOM   2160 C C     . GLN A 1 273 ? -8.699  -12.834 -1.863  1.000 14.595 0 273 GLN A C     1 ? 
ATOM   2161 O O     . GLN A 1 273 ? -8.868  -11.646 -2.131  1.000 14.310 0 273 GLN A O     1 ? 
ATOM   2162 C CB    . GLN A 1 273 ? -10.898 -14.060 -2.107  1.000 19.710 0 273 GLN A CB    1 ? 
ATOM   2163 C CG    . GLN A 1 273 ? -11.883 -14.988 -1.449  1.000 21.463 0 273 GLN A CG    1 ? 
ATOM   2164 C CD    . GLN A 1 273 ? -11.409 -16.411 -1.563  1.000 26.217 0 273 GLN A CD    1 ? 
ATOM   2165 O OE1   . GLN A 1 273 ? -10.236 -16.673 -1.762  1.000 24.574 0 273 GLN A OE1   1 ? 
ATOM   2166 N NE2   . GLN A 1 273 ? -12.327 -17.343 -1.422  1.000 30.122 0 273 GLN A NE2   1 ? 
ATOM   2167 N N     . PRO A 1 274 ? -7.566  -13.471 -2.213  1.000 15.938 0 274 PRO A N     1 ? 
ATOM   2168 C CA    . PRO A 1 274 ? -7.349  -14.899 -1.978  1.000 17.032 0 274 PRO A CA    1 ? 
ATOM   2169 C C     . PRO A 1 274 ? -6.603  -15.308 -0.705  1.000 17.774 0 274 PRO A C     1 ? 
ATOM   2170 O O     . PRO A 1 274 ? -6.107  -16.443 -0.664  1.000 19.243 0 274 PRO A O     1 ? 
ATOM   2171 C CB    . PRO A 1 274 ? -6.512  -15.268 -3.197  1.000 16.740 0 274 PRO A CB    1 ? 
ATOM   2172 C CG    . PRO A 1 274 ? -5.662  -14.073 -3.439  1.000 16.923 0 274 PRO A CG    1 ? 
ATOM   2173 C CD    . PRO A 1 274 ? -6.506  -12.881 -3.035  1.000 16.485 0 274 PRO A CD    1 ? 
ATOM   2174 N N     . TYR A 1 275 ? -6.576  -14.434 0.300   1.000 15.325 0 275 TYR A N     1 ? 
ATOM   2175 C CA    . TYR A 1 275 ? -6.102  -14.704 1.685   1.000 15.829 0 275 TYR A CA    1 ? 
ATOM   2176 C C     . TYR A 1 275 ? -4.618  -15.075 1.665   1.000 15.145 0 275 TYR A C     1 ? 
ATOM   2177 O O     . TYR A 1 275 ? -4.173  -15.833 2.533   1.000 17.084 0 275 TYR A O     1 ? 
ATOM   2178 C CB    . TYR A 1 275 ? -6.914  -15.814 2.371   1.000 17.875 0 275 TYR A CB    1 ? 
ATOM   2179 C CG    . TYR A 1 275 ? -8.401  -15.587 2.420   1.000 18.205 0 275 TYR A CG    1 ? 
ATOM   2180 C CD1   . TYR A 1 275 ? -8.956  -14.607 3.226   1.000 17.874 0 275 TYR A CD1   1 ? 
ATOM   2181 C CD2   . TYR A 1 275 ? -9.270  -16.387 1.694   1.000 20.585 0 275 TYR A CD2   1 ? 
ATOM   2182 C CE1   . TYR A 1 275 ? -10.327 -14.412 3.290   1.000 18.892 0 275 TYR A CE1   1 ? 
ATOM   2183 C CE2   . TYR A 1 275 ? -10.647 -16.206 1.761   1.000 21.694 0 275 TYR A CE2   1 ? 
ATOM   2184 C CZ    . TYR A 1 275 ? -11.174 -15.218 2.563   1.000 20.256 0 275 TYR A CZ    1 ? 
ATOM   2185 O OH    . TYR A 1 275 ? -12.527 -14.999 2.607   1.000 24.018 0 275 TYR A OH    1 ? 
ATOM   2186 N N     . ASN A 1 276 ? -3.871  -14.522 0.724   1.000 14.297 0 276 ASN A N     1 ? 
ATOM   2187 C CA    . ASN A 1 276 ? -2.432  -14.836 0.532   1.000 15.713 0 276 ASN A CA    1 ? 
ATOM   2188 C C     . ASN A 1 276 ? -1.612  -14.006 1.525   1.000 15.715 0 276 ASN A C     1 ? 
ATOM   2189 O O     . ASN A 1 276 ? -2.063  -12.928 1.943   1.000 13.196 0 276 ASN A O     1 ? 
ATOM   2190 C CB    . ASN A 1 276 ? -2.008  -14.612 -0.917  1.000 16.373 0 276 ASN A CB    1 ? 
ATOM   2191 C CG    . ASN A 1 276 ? -2.085  -13.162 -1.329  1.000 17.817 0 276 ASN A CG    1 ? 
ATOM   2192 O OD1   . ASN A 1 276 ? -3.164  -12.563 -1.383  1.000 16.912 0 276 ASN A OD1   1 ? 
ATOM   2193 N ND2   . ASN A 1 276 ? -0.935  -12.570 -1.591  1.000 21.948 0 276 ASN A ND2   1 ? 
ATOM   2194 N N     . ASP A 1 277 ? -0.434  -14.500 1.867   1.000 15.267 0 277 ASP A N     1 ? 
ATOM   2195 C CA    . ASP A 1 277 ? 0.563   -13.750 2.658   1.000 14.173 0 277 ASP A CA    1 ? 
ATOM   2196 C C     . ASP A 1 277 ? 1.152   -12.688 1.737   1.000 15.273 0 277 ASP A C     1 ? 
ATOM   2197 O O     . ASP A 1 277 ? 1.908   -13.030 0.807   1.000 16.406 0 277 ASP A O     1 ? 
ATOM   2198 C CB    . ASP A 1 277 ? 1.603   -14.694 3.234   1.000 15.759 0 277 ASP A CB    1 ? 
ATOM   2199 C CG    . ASP A 1 277 ? 2.787   -13.992 3.849   1.000 15.879 0 277 ASP A CG    1 ? 
ATOM   2200 O OD1   . ASP A 1 277 ? 2.668   -12.776 4.182   1.000 13.804 0 277 ASP A OD1   1 ? 
ATOM   2201 O OD2   . ASP A 1 277 ? 3.790   -14.634 3.970   1.000 14.120 0 277 ASP A OD2   1 ? 
ATOM   2202 N N     . VAL A 1 278 ? 0.841   -11.434 2.013   1.000 14.433 0 278 VAL A N     1 ? 
ATOM   2203 C CA    . VAL A 1 278 ? 1.236   -10.320 1.134   1.000 15.986 0 278 VAL A CA    1 ? 
ATOM   2204 C C     . VAL A 1 278 ? 2.759   -10.113 1.209   1.000 17.502 0 278 VAL A C     1 ? 
ATOM   2205 O O     . VAL A 1 278 ? 3.275   -9.487  0.316   1.000 17.517 0 278 VAL A O     1 ? 
ATOM   2206 C CB    . VAL A 1 278 ? 0.421   -9.061  1.453   1.000 18.700 0 278 VAL A CB    1 ? 
ATOM   2207 C CG1   . VAL A 1 278 ? -1.071  -9.280  1.143   1.000 21.925 0 278 VAL A CG1   1 ? 
ATOM   2208 C CG2   . VAL A 1 278 ? 0.600   -8.625  2.862   1.000 19.904 0 278 VAL A CG2   1 ? 
ATOM   2209 N N     . PHE A 1 279 ? 3.455   -10.666 2.212   1.000 17.307 0 279 PHE A N     1 ? 
ATOM   2210 C CA    . PHE A 1 279 ? 4.934   -10.568 2.345   1.000 17.882 0 279 PHE A CA    1 ? 
ATOM   2211 C C     . PHE A 1 279 ? 5.658   -11.824 1.867   1.000 18.288 0 279 PHE A C     1 ? 
ATOM   2212 O O     . PHE A 1 279 ? 6.878   -11.854 2.023   1.000 17.215 0 279 PHE A O     1 ? 
ATOM   2213 C CB    . PHE A 1 279 ? 5.323   -10.309 3.802   1.000 19.221 0 279 PHE A CB    1 ? 
ATOM   2214 C CG    . PHE A 1 279 ? 5.009   -8.912  4.253   1.000 19.900 0 279 PHE A CG    1 ? 
ATOM   2215 C CD1   . PHE A 1 279 ? 5.273   -7.831  3.429   1.000 22.665 0 279 PHE A CD1   1 ? 
ATOM   2216 C CD2   . PHE A 1 279 ? 4.473   -8.670  5.501   1.000 22.713 0 279 PHE A CD2   1 ? 
ATOM   2217 C CE1   . PHE A 1 279 ? 4.964   -6.543  3.836   1.000 23.329 0 279 PHE A CE1   1 ? 
ATOM   2218 C CE2   . PHE A 1 279 ? 4.178   -7.371  5.909   1.000 25.092 0 279 PHE A CE2   1 ? 
ATOM   2219 C CZ    . PHE A 1 279 ? 4.459   -6.313  5.089   1.000 23.271 0 279 PHE A CZ    1 ? 
ATOM   2220 N N     . GLU A 1 280 ? 4.987   -12.742 1.184   1.000 18.449 0 280 GLU A N     1 ? 
ATOM   2221 C CA    . GLU A 1 280 ? 5.582   -14.074 0.853   1.000 20.426 0 280 GLU A CA    1 ? 
ATOM   2222 C C     . GLU A 1 280 ? 6.783   -13.903 -0.096  1.000 20.185 0 280 GLU A C     1 ? 
ATOM   2223 O O     . GLU A 1 280 ? 7.637   -14.777 -0.054  1.000 20.729 0 280 GLU A O     1 ? 
ATOM   2224 C CB    . GLU A 1 280 ? 4.554   -15.037 0.250   1.000 21.370 0 280 GLU A CB    1 ? 
ATOM   2225 C CG    . GLU A 1 280 ? 3.959   -14.610 -1.083  1.000 22.830 0 280 GLU A CG    1 ? 
ATOM   2226 C CD    . GLU A 1 280 ? 2.619   -15.293 -1.351  1.000 26.803 0 280 GLU A CD    1 ? 
ATOM   2227 O OE1   . GLU A 1 280 ? 2.436   -16.428 -0.853  1.000 30.238 0 280 GLU A OE1   1 ? 
ATOM   2228 O OE2   . GLU A 1 280 ? 1.737   -14.662 -1.943  1.000 28.939 0 280 GLU A OE2   1 ? 
ATOM   2229 N N     . LYS A 1 281 ? 6.850   -12.832 -0.897  1.000 19.882 0 281 LYS A N     1 ? 
ATOM   2230 C CA    . LYS A 1 281 ? 7.925   -12.653 -1.915  1.000 22.757 0 281 LYS A CA    1 ? 
ATOM   2231 C C     . LYS A 1 281 ? 9.221   -12.173 -1.237  1.000 21.634 0 281 LYS A C     1 ? 
ATOM   2232 O O     . LYS A 1 281 ? 10.289  -12.382 -1.805  1.000 16.652 0 281 LYS A O     1 ? 
ATOM   2233 C CB    . LYS A 1 281 ? 7.490   -11.711 -3.043  1.000 29.070 0 281 LYS A CB    1 ? 
ATOM   2234 C CG    . LYS A 1 281 ? 6.444   -12.277 -4.001  1.000 34.011 0 281 LYS A CG    1 ? 
ATOM   2235 C CD    . LYS A 1 281 ? 6.711   -13.702 -4.465  1.000 38.629 0 281 LYS A CD    1 ? 
ATOM   2236 C CE    . LYS A 1 281 ? 5.736   -14.176 -5.528  1.000 46.875 0 281 LYS A CE    1 ? 
ATOM   2237 N NZ    . LYS A 1 281 ? 5.317   -15.584 -5.306  1.000 49.021 0 281 LYS A NZ    1 ? 
ATOM   2238 N N     . MET A 1 282 ? 9.144   -11.653 -0.012  1.000 17.470 0 282 MET A N     1 ? 
ATOM   2239 C CA    . MET A 1 282 ? 10.330  -11.150 0.715   1.000 17.039 0 282 MET A CA    1 ? 
ATOM   2240 C C     . MET A 1 282 ? 11.188  -12.339 1.118   1.000 15.078 0 282 MET A C     1 ? 
ATOM   2241 O O     . MET A 1 282 ? 10.632  -13.324 1.619   1.000 14.538 0 282 MET A O     1 ? 
ATOM   2242 C CB    . MET A 1 282 ? 9.919   -10.357 1.950   1.000 19.028 0 282 MET A CB    1 ? 
ATOM   2243 C CG    . MET A 1 282 ? 9.233   -9.080  1.577   1.000 24.532 0 282 MET A CG    1 ? 
ATOM   2244 S SD    . MET A 1 282 ? 9.025   -7.908  2.919   1.000 29.709 0 282 MET A SD    1 ? 
ATOM   2245 C CE    . MET A 1 282 ? 10.584  -8.131  3.814   1.000 16.457 0 282 MET A CE    1 ? 
ATOM   2246 N N     . THR A 1 283 ? 12.502  -12.261 0.910   1.000 13.134 0 283 THR A N     1 ? 
ATOM   2247 C CA    . THR A 1 283 ? 13.407  -13.393 1.211   1.000 13.695 0 283 THR A CA    1 ? 
ATOM   2248 C C     . THR A 1 283 ? 13.600  -13.436 2.726   1.000 13.018 0 283 THR A C     1 ? 
ATOM   2249 O O     . THR A 1 283 ? 13.240  -12.453 3.361   1.000 10.559 0 283 THR A O     1 ? 
ATOM   2250 C CB    . THR A 1 283 ? 14.743  -13.267 0.469   1.000 14.431 0 283 THR A CB    1 ? 
ATOM   2251 O OG1   . THR A 1 283 ? 15.410  -12.127 0.997   1.000 13.771 0 283 THR A OG1   1 ? 
ATOM   2252 C CG2   . THR A 1 283 ? 14.589  -13.188 -1.028  1.000 16.428 0 283 THR A CG2   1 ? 
ATOM   2253 N N     . GLY A 1 284 ? 14.196  -14.493 3.272   1.000 11.797 0 284 GLY A N     1 ? 
ATOM   2254 C CA    . GLY A 1 284 ? 14.521  -14.537 4.708   1.000 11.685 0 284 GLY A CA    1 ? 
ATOM   2255 C C     . GLY A 1 284 ? 15.495  -13.425 5.089   1.000 12.382 0 284 GLY A C     1 ? 
ATOM   2256 O O     . GLY A 1 284 ? 15.324  -12.808 6.178   1.000 12.737 0 284 GLY A O     1 ? 
ATOM   2257 N N     . MET A 1 285 ? 16.487  -13.134 4.256   1.000 12.938 0 285 MET A N     1 ? 
ATOM   2258 C CA    . MET A 1 285 ? 17.496  -12.077 4.573   1.000 13.728 0 285 MET A CA    1 ? 
ATOM   2259 C C     . MET A 1 285 ? 16.811  -10.691 4.569   1.000 11.838 0 285 MET A C     1 ? 
ATOM   2260 O O     . MET A 1 285 ? 17.129  -9.868  5.441   1.000 10.749 0 285 MET A O     1 ? 
ATOM   2261 C CB    . MET A 1 285 ? 18.644  -12.076 3.550   1.000 16.521 0 285 MET A CB    1 ? 
ATOM   2262 C CG    . MET A 1 285 ? 19.718  -13.113 3.821   1.000 18.997 0 285 MET A CG    1 ? 
ATOM   2263 S SD    . MET A 1 285 ? 20.506  -12.968 5.422   1.000 23.549 0 285 MET A SD    1 ? 
ATOM   2264 C CE    . MET A 1 285 ? 21.881  -11.878 5.045   1.000 27.894 0 285 MET A CE    1 ? 
ATOM   2265 N N     . GLN A 1 286 ? 15.890  -10.464 3.636   1.000 12.550 0 286 GLN A N     1 ? 
ATOM   2266 C CA    . GLN A 1 286 ? 15.105  -9.213  3.546   1.000 12.296 0 286 GLN A CA    1 ? 
ATOM   2267 C C     . GLN A 1 286 ? 14.239  -9.083  4.794   1.000 12.493 0 286 GLN A C     1 ? 
ATOM   2268 O O     . GLN A 1 286 ? 14.155  -7.956  5.354   1.000 10.197 0 286 GLN A O     1 ? 
ATOM   2269 C CB    . GLN A 1 286 ? 14.300  -9.172  2.263   1.000 14.118 0 286 GLN A CB    1 ? 
ATOM   2270 C CG    . GLN A 1 286 ? 15.204  -9.020  1.054   1.000 16.336 0 286 GLN A CG    1 ? 
ATOM   2271 C CD    . GLN A 1 286 ? 14.500  -9.248  -0.262  1.000 17.726 0 286 GLN A CD    1 ? 
ATOM   2272 O OE1   . GLN A 1 286 ? 13.426  -9.854  -0.341  1.000 16.879 0 286 GLN A OE1   1 ? 
ATOM   2273 N NE2   . GLN A 1 286 ? 15.146  -8.804  -1.334  1.000 19.144 0 286 GLN A NE2   1 ? 
ATOM   2274 N N     . MET A 1 287 ? 13.668  -10.209 5.275   1.000 11.742 0 287 MET A N     1 ? 
ATOM   2275 C CA    . MET A 1 287 ? 12.806  -10.194 6.476   1.000 13.035 0 287 MET A CA    1 ? 
ATOM   2276 C C     . MET A 1 287 ? 13.627  -9.852  7.705   1.000 11.322 0 287 MET A C     1 ? 
ATOM   2277 O O     . MET A 1 287 ? 13.091  -9.147  8.540   1.000 12.664 0 287 MET A O     1 ? 
ATOM   2278 C CB    . MET A 1 287 ? 12.085  -11.532 6.722   1.000 11.965 0 287 MET A CB    1 ? 
ATOM   2279 C CG    . MET A 1 287 ? 10.809  -11.622 5.951   1.000 13.599 0 287 MET A CG    1 ? 
ATOM   2280 S SD    . MET A 1 287 ? 9.518   -10.724 6.763   1.000 13.083 0 287 MET A SD    1 ? 
ATOM   2281 C CE    . MET A 1 287 ? 8.233   -10.893 5.538   1.000 15.134 0 287 MET A CE    1 ? 
ATOM   2282 N N     . GLU A 1 288 ? 14.836  -10.403 7.850   1.000 11.640 0 288 GLU A N     1 ? 
ATOM   2283 C CA    . GLU A 1 288 ? 15.753  -10.114 8.975   1.000 11.520 0 288 GLU A CA    1 ? 
ATOM   2284 C C     . GLU A 1 288 ? 16.043  -8.599  8.971   1.000 10.503 0 288 GLU A C     1 ? 
ATOM   2285 O O     . GLU A 1 288 ? 16.000  -7.992  10.050  1.000 8.894  0 288 GLU A O     1 ? 
ATOM   2286 C CB    . GLU A 1 288 ? 17.033  -10.953 8.818   1.000 14.252 0 288 GLU A CB    1 ? 
ATOM   2287 C CG    . GLU A 1 288 ? 18.014  -10.813 9.928   1.000 16.944 0 288 GLU A CG    1 ? 
ATOM   2288 C CD    . GLU A 1 288 ? 19.266  -11.664 9.707   1.000 21.778 0 288 GLU A CD    1 ? 
ATOM   2289 O OE1   . GLU A 1 288 ? 20.073  -11.327 8.788   1.000 21.341 0 288 GLU A OE1   1 ? 
ATOM   2290 O OE2   . GLU A 1 288 ? 19.346  -12.724 10.325  1.000 23.981 0 288 GLU A OE2   1 ? 
ATOM   2291 N N     . SER A 1 289 ? 16.279  -8.007  7.798   1.000 10.870 0 289 SER A N     1 ? 
ATOM   2292 C CA    . SER A 1 289 ? 16.623  -6.565  7.669   1.000 12.123 0 289 SER A CA    1 ? 
ATOM   2293 C C     . SER A 1 289 ? 15.370  -5.725  7.998   1.000 11.905 0 289 SER A C     1 ? 
ATOM   2294 O O     . SER A 1 289 ? 15.491  -4.783  8.790   1.000 12.473 0 289 SER A O     1 ? 
ATOM   2295 C CB    . SER A 1 289 ? 17.209  -6.214  6.331   1.000 15.075 0 289 SER A CB    1 ? 
ATOM   2296 O OG    . SER A 1 289 ? 17.602  -4.851  6.334   1.000 19.151 0 289 SER A OG    1 ? 
ATOM   2297 N N     . PHE A 1 290 ? 14.200  -6.150  7.535   1.000 11.513 0 290 PHE A N     1 ? 
ATOM   2298 C CA    . PHE A 1 290 ? 12.887  -5.554  7.872   1.000 12.177 0 290 PHE A CA    1 ? 
ATOM   2299 C C     . PHE A 1 290 ? 12.710  -5.551  9.396   1.000 10.682 0 290 PHE A C     1 ? 
ATOM   2300 O O     . PHE A 1 290 ? 12.432  -4.500  9.975   1.000 9.439  0 290 PHE A O     1 ? 
ATOM   2301 C CB    . PHE A 1 290 ? 11.807  -6.247  7.040   1.000 11.946 0 290 PHE A CB    1 ? 
ATOM   2302 C CG    . PHE A 1 290 ? 10.371  -5.862  7.303   1.000 11.932 0 290 PHE A CG    1 ? 
ATOM   2303 C CD1   . PHE A 1 290 ? 10.014  -4.603  7.757   1.000 11.581 0 290 PHE A CD1   1 ? 
ATOM   2304 C CD2   . PHE A 1 290 ? 9.370   -6.765  7.019   1.000 12.964 0 290 PHE A CD2   1 ? 
ATOM   2305 C CE1   . PHE A 1 290 ? 8.682   -4.278  7.963   1.000 12.652 0 290 PHE A CE1   1 ? 
ATOM   2306 C CE2   . PHE A 1 290 ? 8.035   -6.459  7.233   1.000 12.895 0 290 PHE A CE2   1 ? 
ATOM   2307 C CZ    . PHE A 1 290 ? 7.691   -5.199  7.702   1.000 12.130 0 290 PHE A CZ    1 ? 
ATOM   2308 N N     . LYS A 1 291 ? 12.889  -6.689  10.046  1.000 11.176 0 291 LYS A N     1 ? 
ATOM   2309 C CA    . LYS A 1 291 ? 12.715  -6.818  11.505  1.000 11.810 0 291 LYS A CA    1 ? 
ATOM   2310 C C     . LYS A 1 291 ? 13.662  -5.871  12.225  1.000 11.142 0 291 LYS A C     1 ? 
ATOM   2311 O O     . LYS A 1 291 ? 13.225  -5.202  13.155  1.000 11.019 0 291 LYS A O     1 ? 
ATOM   2312 C CB    . LYS A 1 291 ? 12.943  -8.260  11.991  1.000 12.926 0 291 LYS A CB    1 ? 
ATOM   2313 C CG    . LYS A 1 291 ? 12.494  -8.467  13.428  1.000 14.721 0 291 LYS A CG    1 ? 
ATOM   2314 C CD    . LYS A 1 291 ? 12.632  -9.871  13.970  1.000 16.661 0 291 LYS A CD    1 ? 
ATOM   2315 C CE    . LYS A 1 291 ? 12.109  -9.973  15.402  1.000 20.175 0 291 LYS A CE    1 ? 
ATOM   2316 N NZ    . LYS A 1 291 ? 12.295  -11.349 15.901  1.000 22.660 0 291 LYS A NZ    1 ? 
ATOM   2317 N N     . SER A 1 292 ? 14.942  -5.858  11.859  1.000 13.114 0 292 SER A N     1 ? 
ATOM   2318 C CA    . SER A 1 292 ? 15.970  -5.009  12.498  1.000 13.463 0 292 SER A CA    1 ? 
ATOM   2319 C C     . SER A 1 292 ? 15.605  -3.521  12.382  1.000 11.550 0 292 SER A C     1 ? 
ATOM   2320 O O     . SER A 1 292 ? 15.714  -2.829  13.358  1.000 10.108 0 292 SER A O     1 ? 
ATOM   2321 C CB    . SER A 1 292 ? 17.357  -5.294  11.954  1.000 15.726 0 292 SER A CB    1 ? 
ATOM   2322 O OG    . SER A 1 292 ? 17.726  -6.619  12.338  1.000 23.749 0 292 SER A OG    1 ? 
ATOM   2323 N N     . LYS A 1 293 ? 15.134  -3.082  11.236  1.000 11.927 0 293 LYS A N     1 ? 
ATOM   2324 C CA    . LYS A 1 293 ? 14.740  -1.671  11.047  1.000 11.455 0 293 LYS A CA    1 ? 
ATOM   2325 C C     . LYS A 1 293 ? 13.436  -1.340  11.787  1.000 10.959 0 293 LYS A C     1 ? 
ATOM   2326 O O     . LYS A 1 293 ? 13.328  -0.224  12.331  1.000 9.714  0 293 LYS A O     1 ? 
ATOM   2327 C CB    . LYS A 1 293 ? 14.681  -1.366  9.558   1.000 12.082 0 293 LYS A CB    1 ? 
ATOM   2328 C CG    . LYS A 1 293 ? 16.061  -1.221  8.954   1.000 14.067 0 293 LYS A CG    1 ? 
ATOM   2329 C CD    . LYS A 1 293 ? 16.009  -0.653  7.502   1.000 15.251 0 293 LYS A CD    1 ? 
ATOM   2330 C CE    . LYS A 1 293 ? 16.094  -1.740  6.502   1.000 15.161 0 293 LYS A CE    1 ? 
ATOM   2331 N NZ    . LYS A 1 293 ? 16.330  -1.197  5.144   1.000 15.426 0 293 LYS A NZ    1 ? 
ATOM   2332 N N     . LEU A 1 294 ? 12.501  -2.262  11.840  1.000 9.898  0 294 LEU A N     1 ? 
ATOM   2333 C CA    . LEU A 1 294 ? 11.298  -2.104  12.667  1.000 11.090 0 294 LEU A CA    1 ? 
ATOM   2334 C C     . LEU A 1 294 ? 11.679  -1.954  14.148  1.000 10.221 0 294 LEU A C     1 ? 
ATOM   2335 O O     . LEU A 1 294 ? 11.131  -1.086  14.819  1.000 8.438  0 294 LEU A O     1 ? 
ATOM   2336 C CB    . LEU A 1 294 ? 10.421  -3.328  12.400  1.000 12.354 0 294 LEU A CB    1 ? 
ATOM   2337 C CG    . LEU A 1 294 ? 8.927   -3.173  12.573  1.000 15.530 0 294 LEU A CG    1 ? 
ATOM   2338 C CD1   . LEU A 1 294 ? 8.384   -1.923  11.865  1.000 15.735 0 294 LEU A CD1   1 ? 
ATOM   2339 C CD2   . LEU A 1 294 ? 8.227   -4.426  12.019  1.000 15.825 0 294 LEU A CD2   1 ? 
ATOM   2340 N N     . GLN A 1 295 ? 12.592  -2.783  14.646  1.000 10.229 0 295 GLN A N     1 ? 
ATOM   2341 C CA    . GLN A 1 295 ? 13.068  -2.698  16.038  1.000 11.026 0 295 GLN A CA    1 ? 
ATOM   2342 C C     . GLN A 1 295 ? 13.740  -1.341  16.276  1.000 10.937 0 295 GLN A C     1 ? 
ATOM   2343 O O     . GLN A 1 295 ? 13.515  -0.740  17.387  1.000 10.362 0 295 GLN A O     1 ? 
ATOM   2344 C CB    . GLN A 1 295 ? 14.040  -3.838  16.341  1.000 11.687 0 295 GLN A CB    1 ? 
ATOM   2345 C CG    . GLN A 1 295 ? 14.478  -3.871  17.798  1.000 14.432 0 295 GLN A CG    1 ? 
ATOM   2346 C CD    . GLN A 1 295 ? 13.305  -4.246  18.677  1.000 14.670 0 295 GLN A CD    1 ? 
ATOM   2347 O OE1   . GLN A 1 295 ? 12.627  -5.267  18.466  1.000 16.732 0 295 GLN A OE1   1 ? 
ATOM   2348 N NE2   . GLN A 1 295 ? 13.003  -3.385  19.625  1.000 14.596 0 295 GLN A NE2   1 ? 
ATOM   2349 N N     . ALA A 1 296 ? 14.545  -0.873  15.318  1.000 11.440 0 296 ALA A N     1 ? 
ATOM   2350 C CA    . ALA A 1 296 ? 15.212  0.448   15.406  1.000 10.738 0 296 ALA A CA    1 ? 
ATOM   2351 C C     . ALA A 1 296 ? 14.137  1.540   15.429  1.000 10.785 0 296 ALA A C     1 ? 
ATOM   2352 O O     . ALA A 1 296 ? 14.286  2.493   16.266  1.000 10.756 0 296 ALA A O     1 ? 
ATOM   2353 C CB    . ALA A 1 296 ? 16.194  0.650   14.277  1.000 11.567 0 296 ALA A CB    1 ? 
ATOM   2354 N N     . LEU A 1 297 ? 13.073  1.417   14.617  1.000 9.747  0 297 LEU A N     1 ? 
ATOM   2355 C CA    . LEU A 1 297 ? 11.955  2.387   14.671  1.000 10.277 0 297 LEU A CA    1 ? 
ATOM   2356 C C     . LEU A 1 297 ? 11.285  2.313   16.054  1.000 9.772  0 297 LEU A C     1 ? 
ATOM   2357 O O     . LEU A 1 297 ? 10.999  3.372   16.604  1.000 9.164  0 297 LEU A O     1 ? 
ATOM   2358 C CB    . LEU A 1 297 ? 10.945  2.143   13.550  1.000 10.370 0 297 LEU A CB    1 ? 
ATOM   2359 C CG    . LEU A 1 297 ? 9.676   2.992   13.608  1.000 10.797 0 297 LEU A CG    1 ? 
ATOM   2360 C CD1   . LEU A 1 297 ? 9.986   4.507   13.589  1.000 11.510 0 297 LEU A CD1   1 ? 
ATOM   2361 C CD2   . LEU A 1 297 ? 8.793   2.603   12.433  1.000 11.927 0 297 LEU A CD2   1 ? 
ATOM   2362 N N     . LEU A 1 298 ? 10.998  1.119   16.564  1.000 10.671 0 298 LEU A N     1 ? 
ATOM   2363 C CA    . LEU A 1 298 ? 10.338  0.975   17.892  1.000 11.134 0 298 LEU A CA    1 ? 
ATOM   2364 C C     . LEU A 1 298 ? 11.190  1.684   18.955  1.000 10.929 0 298 LEU A C     1 ? 
ATOM   2365 O O     . LEU A 1 298 ? 10.650  2.446   19.780  1.000 10.180 0 298 LEU A O     1 ? 
ATOM   2366 C CB    . LEU A 1 298 ? 10.141  -0.509  18.252  1.000 12.255 0 298 LEU A CB    1 ? 
ATOM   2367 C CG    . LEU A 1 298 ? 9.520   -0.700  19.630  1.000 15.493 0 298 LEU A CG    1 ? 
ATOM   2368 C CD1   . LEU A 1 298 ? 8.121   -0.119  19.656  1.000 17.036 0 298 LEU A CD1   1 ? 
ATOM   2369 C CD2   . LEU A 1 298 ? 9.496   -2.147  20.044  1.000 21.385 0 298 LEU A CD2   1 ? 
ATOM   2370 N N     . ASN A 1 299 ? 12.495  1.447   18.952  1.000 11.363 0 299 ASN A N     1 ? 
ATOM   2371 C CA    . ASN A 1 299 ? 13.436  2.037   19.940  1.000 11.843 0 299 ASN A CA    1 ? 
ATOM   2372 C C     . ASN A 1 299 ? 13.397  3.581   19.871  1.000 11.942 0 299 ASN A C     1 ? 
ATOM   2373 O O     . ASN A 1 299 ? 13.386  4.210   20.916  1.000 10.851 0 299 ASN A O     1 ? 
ATOM   2374 C CB    . ASN A 1 299 ? 14.843  1.453   19.747  1.000 13.777 0 299 ASN A CB    1 ? 
ATOM   2375 C CG    . ASN A 1 299 ? 14.948  -0.032  20.047  1.000 15.456 0 299 ASN A CG    1 ? 
ATOM   2376 O OD1   . ASN A 1 299 ? 14.027  -0.662  20.542  1.000 18.428 0 299 ASN A OD1   1 ? 
ATOM   2377 N ND2   . ASN A 1 299 ? 16.079  -0.629  19.719  1.000 18.903 0 299 ASN A ND2   1 ? 
ATOM   2378 N N     . ALA A 1 300 ? 13.284  4.171   18.687  1.000 10.263 0 300 ALA A N     1 ? 
ATOM   2379 C CA    . ALA A 1 300 ? 13.185  5.626   18.492  1.000 10.225 0 300 ALA A CA    1 ? 
ATOM   2380 C C     . ALA A 1 300 ? 11.838  6.131   19.042  1.000 10.321 0 300 ALA A C     1 ? 
ATOM   2381 O O     . ALA A 1 300 ? 11.838  7.192   19.696  1.000 9.642  0 300 ALA A O     1 ? 
ATOM   2382 C CB    . ALA A 1 300 ? 13.343  5.970   17.027  1.000 10.351 0 300 ALA A CB    1 ? 
ATOM   2383 N N     . LEU A 1 301 ? 10.735  5.401   18.799  1.000 10.598 0 301 LEU A N     1 ? 
ATOM   2384 C CA    . LEU A 1 301 ? 9.408   5.811   19.294  1.000 10.811 0 301 LEU A CA    1 ? 
ATOM   2385 C C     . LEU A 1 301 ? 9.484   5.874   20.834  1.000 11.930 0 301 LEU A C     1 ? 
ATOM   2386 O O     . LEU A 1 301 ? 8.926   6.822   21.435  1.000 11.609 0 301 LEU A O     1 ? 
ATOM   2387 C CB    . LEU A 1 301 ? 8.324   4.868   18.777  1.000 10.205 0 301 LEU A CB    1 ? 
ATOM   2388 C CG    . LEU A 1 301 ? 8.011   5.003   17.274  1.000 10.573 0 301 LEU A CG    1 ? 
ATOM   2389 C CD1   . LEU A 1 301 ? 7.252   3.775   16.760  1.000 9.964  0 301 LEU A CD1   1 ? 
ATOM   2390 C CD2   . LEU A 1 301 ? 7.238   6.279   16.994  1.000 10.164 0 301 LEU A CD2   1 ? 
ATOM   2391 N N     . LYS A 1 302 ? 10.191  4.930   21.446  1.000 12.779 0 302 LYS A N     1 ? 
ATOM   2392 C CA    . LYS A 1 302 ? 10.325  4.839   22.924  1.000 15.006 0 302 LYS A CA    1 ? 
ATOM   2393 C C     . LYS A 1 302 ? 11.252  5.942   23.440  1.000 16.059 0 302 LYS A C     1 ? 
ATOM   2394 O O     . LYS A 1 302 ? 10.903  6.594   24.434  1.000 16.168 0 302 LYS A O     1 ? 
ATOM   2395 C CB    . LYS A 1 302 ? 10.782  3.431   23.317  1.000 16.511 0 302 LYS A CB    1 ? 
ATOM   2396 C CG    . LYS A 1 302 ? 9.643   2.446   23.478  1.000 18.887 0 302 LYS A CG    1 ? 
ATOM   2397 C CD    . LYS A 1 302 ? 10.109  1.062   23.820  1.000 24.114 0 302 LYS A CD    1 ? 
ATOM   2398 C CE    . LYS A 1 302 ? 8.965   0.105   24.075  1.000 26.986 0 302 LYS A CE    1 ? 
ATOM   2399 N NZ    . LYS A 1 302 ? 9.477   -1.142  24.700  1.000 34.826 0 302 LYS A NZ    1 ? 
ATOM   2400 N N     . THR A 1 303 ? 12.372  6.190   22.764  1.000 17.176 0 303 THR A N     1 ? 
ATOM   2401 C CA    . THR A 1 303 ? 13.318  7.284   23.118  1.000 19.541 0 303 THR A CA    1 ? 
ATOM   2402 C C     . THR A 1 303 ? 12.612  8.630   23.029  1.000 19.312 0 303 THR A C     1 ? 
ATOM   2403 O O     . THR A 1 303 ? 12.790  9.452   23.956  1.000 17.608 0 303 THR A O     1 ? 
ATOM   2404 C CB    . THR A 1 303 ? 14.553  7.246   22.219  1.000 19.816 0 303 THR A CB    1 ? 
ATOM   2405 O OG1   . THR A 1 303 ? 15.055  5.918   22.370  1.000 23.061 0 303 THR A OG1   1 ? 
ATOM   2406 C CG2   . THR A 1 303 ? 15.578  8.283   22.587  1.000 23.233 0 303 THR A CG2   1 ? 
ATOM   2407 N N     . ALA A 1 304 ? 11.803  8.841   21.977  1.000 18.757 0 304 ALA A N     1 ? 
ATOM   2408 C CA    . ALA A 1 304 ? 11.057  10.099  21.766  1.000 18.499 0 304 ALA A CA    1 ? 
ATOM   2409 C C     . ALA A 1 304 ? 10.224  10.409  23.008  1.000 20.873 0 304 ALA A C     1 ? 
ATOM   2410 O O     . ALA A 1 304 ? 10.194  11.617  23.411  1.000 26.040 0 304 ALA A O     1 ? 
ATOM   2411 C CB    . ALA A 1 304 ? 10.185  10.028  20.568  1.000 16.913 0 304 ALA A CB    1 ? 
ATOM   2412 N N     . LYS A 1 305 ? 9.588   9.389   23.592  1.000 17.636 0 305 LYS A N     1 ? 
ATOM   2413 C CA    . LYS A 1 305 ? 8.671   9.556   24.741  1.000 17.731 0 305 LYS A CA    1 ? 
ATOM   2414 C C     . LYS A 1 305 ? 9.447   10.133  25.933  1.000 20.371 0 305 LYS A C     1 ? 
ATOM   2415 O O     . LYS A 1 305 ? 8.838   10.879  26.717  1.000 26.984 0 305 LYS A O     1 ? 
ATOM   2416 C CB    . LYS A 1 305 ? 8.064   8.221   25.155  1.000 19.487 0 305 LYS A CB    1 ? 
ATOM   2417 C CG    . LYS A 1 305 ? 6.909   8.291   26.137  1.000 20.040 0 305 LYS A CG    1 ? 
ATOM   2418 C CD    . LYS A 1 305 ? 6.415   6.930   26.542  1.000 22.751 0 305 LYS A CD    1 ? 
ATOM   2419 C CE    . LYS A 1 305 ? 5.226   6.969   27.484  1.000 24.626 0 305 LYS A CE    1 ? 
ATOM   2420 N NZ    . LYS A 1 305 ? 4.760   5.591   27.752  1.000 25.093 0 305 LYS A NZ    1 ? 
ATOM   2421 N N     . SER A 1 306 ? 10.713  9.767   26.112  1.000 23.049 0 306 SER A N     1 ? 
ATOM   2422 C CA    . SER A 1 306 ? 11.437  10.008  27.397  1.000 24.030 0 306 SER A CA    1 ? 
ATOM   2423 C C     . SER A 1 306 ? 12.377  11.212  27.299  1.000 26.580 0 306 SER A C     1 ? 
ATOM   2424 O O     . SER A 1 306 ? 12.869  11.630  28.340  1.000 27.183 0 306 SER A O     1 ? 
ATOM   2425 C CB    . SER A 1 306 ? 12.156  8.791   27.850  1.000 26.294 0 306 SER A CB    1 ? 
ATOM   2426 O OG    . SER A 1 306 ? 13.105  8.368   26.891  1.000 27.338 0 306 SER A OG    1 ? 
ATOM   2427 N N     . ARG A 1 307 ? 12.632  11.762  26.109  1.000 24.048 0 307 ARG A N     1 ? 
ATOM   2428 C CA    . ARG A 1 307 ? 13.602  12.882  25.963  1.000 26.752 0 307 ARG A CA    1 ? 
ATOM   2429 C C     . ARG A 1 307 ? 13.150  14.116  26.769  1.000 26.804 0 307 ARG A C     1 ? 
ATOM   2430 O O     . ARG A 1 307 ? 11.970  14.528  26.654  1.000 27.962 0 307 ARG A O     1 ? 
ATOM   2431 C CB    . ARG A 1 307 ? 13.800  13.261  24.497  1.000 27.083 0 307 ARG A CB    1 ? 
ATOM   2432 C CG    . ARG A 1 307 ? 14.578  12.246  23.684  1.000 27.709 0 307 ARG A CG    1 ? 
ATOM   2433 C CD    . ARG A 1 307 ? 15.844  11.757  24.347  1.000 30.956 0 307 ARG A CD    1 ? 
ATOM   2434 N NE    . ARG A 1 307 ? 15.556  10.642  25.233  1.000 32.615 0 307 ARG A NE    1 ? 
ATOM   2435 C CZ    . ARG A 1 307 ? 16.476  9.944   25.892  1.000 35.052 0 307 ARG A CZ    1 ? 
ATOM   2436 N NH1   . ARG A 1 307 ? 17.753  10.248  25.766  1.000 40.431 0 307 ARG A NH1   1 ? 
ATOM   2437 N NH2   . ARG A 1 307 ? 16.114  8.940   26.673  1.000 36.243 0 307 ARG A NH2   1 ? 
ATOM   2438 N N     . LEU A 1 308 ? 14.105  14.751  27.443  1.000 29.036 0 308 LEU A N     1 ? 
ATOM   2439 C CA    . LEU A 1 308 ? 13.942  16.053  28.152  1.000 31.916 0 308 LEU A CA    1 ? 
ATOM   2440 C C     . LEU A 1 308 ? 13.498  17.112  27.136  1.000 31.491 0 308 LEU A C     1 ? 
ATOM   2441 O O     . LEU A 1 308 ? 12.554  17.857  27.425  1.000 33.801 0 308 LEU A O     1 ? 
ATOM   2442 C CB    . LEU A 1 308 ? 15.275  16.433  28.812  1.000 32.540 0 308 LEU A CB    1 ? 
ATOM   2443 C CG    . LEU A 1 308 ? 15.329  17.822  29.451  1.000 35.811 0 308 LEU A CG    1 ? 
ATOM   2444 C CD1   . LEU A 1 308 ? 14.393  17.902  30.654  1.000 37.634 0 308 LEU A CD1   1 ? 
ATOM   2445 C CD2   . LEU A 1 308 ? 16.755  18.185  29.837  1.000 35.634 0 308 LEU A CD2   1 ? 
ATOM   2446 N N     . GLU A 1 309 ? 14.133  17.122  25.968  1.000 25.455 0 309 GLU A N     1 ? 
ATOM   2447 C CA    . GLU A 1 309 ? 14.060  18.226  24.995  1.000 23.706 0 309 GLU A CA    1 ? 
ATOM   2448 C C     . GLU A 1 309 ? 13.184  17.767  23.819  1.000 19.338 0 309 GLU A C     1 ? 
ATOM   2449 O O     . GLU A 1 309 ? 13.466  16.669  23.267  1.000 16.139 0 309 GLU A O     1 ? 
ATOM   2450 C CB    . GLU A 1 309 ? 15.489  18.551  24.567  1.000 27.493 0 309 GLU A CB    1 ? 
ATOM   2451 C CG    . GLU A 1 309 ? 15.773  20.008  24.301  1.000 36.599 0 309 GLU A CG    1 ? 
ATOM   2452 C CD    . GLU A 1 309 ? 15.469  20.971  25.432  1.000 35.192 0 309 GLU A CD    1 ? 
ATOM   2453 O OE1   . GLU A 1 309 ? 14.500  21.712  25.295  1.000 45.225 0 309 GLU A OE1   1 ? 
ATOM   2454 O OE2   . GLU A 1 309 ? 16.219  20.984  26.444  1.000 39.579 0 309 GLU A OE2   1 ? 
ATOM   2455 N N     . LEU A 1 310 ? 12.187  18.555  23.436  1.000 17.301 0 310 LEU A N     1 ? 
ATOM   2456 C CA    . LEU A 1 310 ? 11.345  18.248  22.250  1.000 18.675 0 310 LEU A CA    1 ? 
ATOM   2457 C C     . LEU A 1 310 ? 12.258  18.110  21.030  1.000 16.895 0 310 LEU A C     1 ? 
ATOM   2458 O O     . LEU A 1 310 ? 12.047  17.185  20.224  1.000 16.407 0 310 LEU A O     1 ? 
ATOM   2459 C CB    . LEU A 1 310 ? 10.314  19.350  22.027  1.000 21.116 0 310 LEU A CB    1 ? 
ATOM   2460 C CG    . LEU A 1 310 ? 9.343   19.097  20.873  1.000 20.349 0 310 LEU A CG    1 ? 
ATOM   2461 C CD1   . LEU A 1 310 ? 8.464   17.884  21.165  1.000 22.044 0 310 LEU A CD1   1 ? 
ATOM   2462 C CD2   . LEU A 1 310 ? 8.487   20.337  20.623  1.000 22.655 0 310 LEU A CD2   1 ? 
ATOM   2463 N N     . HIS A 1 311 ? 13.259  18.986  20.902  1.000 15.252 0 311 HIS A N     1 ? 
ATOM   2464 C CA    . HIS A 1 311 ? 14.267  18.907  19.817  1.000 15.388 0 311 HIS A CA    1 ? 
ATOM   2465 C C     . HIS A 1 311 ? 14.812  17.476  19.695  1.000 14.221 0 311 HIS A C     1 ? 
ATOM   2466 O O     . HIS A 1 311 ? 14.845  16.930  18.546  1.000 13.614 0 311 HIS A O     1 ? 
ATOM   2467 C CB    . HIS A 1 311 ? 15.428  19.864  20.046  1.000 15.657 0 311 HIS A CB    1 ? 
ATOM   2468 C CG    . HIS A 1 311 ? 16.530  19.663  19.060  1.000 16.390 0 311 HIS A CG    1 ? 
ATOM   2469 N ND1   . HIS A 1 311 ? 16.526  20.271  17.822  1.000 18.578 0 311 HIS A ND1   1 ? 
ATOM   2470 C CD2   . HIS A 1 311 ? 17.628  18.903  19.088  1.000 17.474 0 311 HIS A CD2   1 ? 
ATOM   2471 C CE1   . HIS A 1 311 ? 17.602  19.913  17.148  1.000 16.587 0 311 HIS A CE1   1 ? 
ATOM   2472 N NE2   . HIS A 1 311 ? 18.278  19.077  17.889  1.000 17.675 0 311 HIS A NE2   1 ? 
ATOM   2473 N N     . ASP A 1 312 ? 15.262  16.899  20.803  1.000 13.699 0 312 ASP A N     1 ? 
ATOM   2474 C CA    . ASP A 1 312 ? 15.954  15.579  20.790  1.000 14.190 0 312 ASP A CA    1 ? 
ATOM   2475 C C     . ASP A 1 312 ? 14.946  14.464  20.460  1.000 13.364 0 312 ASP A C     1 ? 
ATOM   2476 O O     . ASP A 1 312 ? 15.294  13.539  19.683  1.000 13.419 0 312 ASP A O     1 ? 
ATOM   2477 C CB    . ASP A 1 312 ? 16.683  15.299  22.102  1.000 15.942 0 312 ASP A CB    1 ? 
ATOM   2478 C CG    . ASP A 1 312 ? 17.815  16.265  22.463  1.000 18.046 0 312 ASP A CG    1 ? 
ATOM   2479 O OD1   . ASP A 1 312 ? 18.294  16.983  21.591  1.000 18.784 0 312 ASP A OD1   1 ? 
ATOM   2480 O OD2   . ASP A 1 312 ? 18.120  16.346  23.655  1.000 23.003 0 312 ASP A OD2   1 ? 
ATOM   2481 N N     . ALA A 1 313 ? 13.733  14.522  21.013  1.000 15.050 0 313 ALA A N     1 ? 
ATOM   2482 C CA    . ALA A 1 313 ? 12.640  13.582  20.689  1.000 13.662 0 313 ALA A CA    1 ? 
ATOM   2483 C C     . ALA A 1 313 ? 12.383  13.571  19.161  1.000 13.939 0 313 ALA A C     1 ? 
ATOM   2484 O O     . ALA A 1 313 ? 12.263  12.490  18.585  1.000 13.259 0 313 ALA A O     1 ? 
ATOM   2485 C CB    . ALA A 1 313 ? 11.396  13.957  21.454  1.000 14.803 0 313 ALA A CB    1 ? 
ATOM   2486 N N     . CYS A 1 314 ? 12.210  14.743  18.542  1.000 12.841 0 314 CYS A N     1 ? 
ATOM   2487 C CA    . CYS A 1 314 ? 11.849  14.884  17.112  1.000 12.371 0 314 CYS A CA    1 ? 
ATOM   2488 C C     . CYS A 1 314 ? 13.030  14.483  16.226  1.000 12.479 0 314 CYS A C     1 ? 
ATOM   2489 O O     . CYS A 1 314 ? 12.815  13.803  15.200  1.000 13.235 0 314 CYS A O     1 ? 
ATOM   2490 C CB    . CYS A 1 314 ? 11.400  16.299  16.815  1.000 12.533 0 314 CYS A CB    1 ? 
ATOM   2491 S SG    . CYS A 1 314 ? 9.822   16.700  17.602  1.000 14.133 0 314 CYS A SG    1 ? 
ATOM   2492 N N     . LYS A 1 315 ? 14.257  14.821  16.626  1.000 13.011 0 315 LYS A N     1 ? 
ATOM   2493 C CA    . LYS A 1 315 ? 15.479  14.392  15.909  1.000 13.592 0 315 LYS A CA    1 ? 
ATOM   2494 C C     . LYS A 1 315 ? 15.504  12.866  15.868  1.000 12.808 0 315 LYS A C     1 ? 
ATOM   2495 O O     . LYS A 1 315 ? 15.760  12.333  14.788  1.000 12.780 0 315 LYS A O     1 ? 
ATOM   2496 C CB    . LYS A 1 315 ? 16.751  14.956  16.563  1.000 16.059 0 315 LYS A CB    1 ? 
ATOM   2497 C CG    . LYS A 1 315 ? 18.060  14.545  15.895  1.000 18.543 0 315 LYS A CG    1 ? 
ATOM   2498 C CD    . LYS A 1 315 ? 19.270  15.277  16.472  1.000 23.539 0 315 LYS A CD    1 ? 
ATOM   2499 C CE    . LYS A 1 315 ? 20.596  14.845  15.867  1.000 26.148 0 315 LYS A CE    1 ? 
ATOM   2500 N NZ    . LYS A 1 315 ? 20.958  15.702  14.715  1.000 35.374 0 315 LYS A NZ    1 ? 
ATOM   2501 N N     . ALA A 1 316 ? 15.193  12.191  16.971  1.000 12.648 0 316 ALA A N     1 ? 
ATOM   2502 C CA    . ALA A 1 316 ? 15.247  10.702  17.057  1.000 12.666 0 316 ALA A CA    1 ? 
ATOM   2503 C C     . ALA A 1 316 ? 14.263  10.099  16.055  1.000 13.077 0 316 ALA A C     1 ? 
ATOM   2504 O O     . ALA A 1 316 ? 14.570  9.065   15.462  1.000 14.212 0 316 ALA A O     1 ? 
ATOM   2505 C CB    . ALA A 1 316 ? 14.970  10.231  18.456  1.000 12.926 0 316 ALA A CB    1 ? 
ATOM   2506 N N     . LEU A 1 317 ? 13.102  10.729  15.861  1.000 12.372 0 317 LEU A N     1 ? 
ATOM   2507 C CA    . LEU A 1 317 ? 12.090  10.258  14.899  1.000 11.332 0 317 LEU A CA    1 ? 
ATOM   2508 C C     . LEU A 1 317 ? 12.507  10.615  13.468  1.000 10.599 0 317 LEU A C     1 ? 
ATOM   2509 O O     . LEU A 1 317 ? 12.255  9.811   12.570  1.000 9.192  0 317 LEU A O     1 ? 
ATOM   2510 C CB    . LEU A 1 317 ? 10.729  10.853  15.300  1.000 12.100 0 317 LEU A CB    1 ? 
ATOM   2511 C CG    . LEU A 1 317 ? 10.243  10.452  16.692  1.000 13.847 0 317 LEU A CG    1 ? 
ATOM   2512 C CD1   . LEU A 1 317 ? 8.897   11.087  17.000  1.000 16.916 0 317 LEU A CD1   1 ? 
ATOM   2513 C CD2   . LEU A 1 317 ? 10.152  8.924   16.791  1.000 15.428 0 317 LEU A CD2   1 ? 
ATOM   2514 N N     . ALA A 1 318 ? 13.001  11.834  13.235  1.000 10.667 0 318 ALA A N     1 ? 
ATOM   2515 C CA    . ALA A 1 318 ? 13.484  12.302  11.905  1.000 11.024 0 318 ALA A CA    1 ? 
ATOM   2516 C C     . ALA A 1 318 ? 14.478  11.277  11.318  1.000 10.502 0 318 ALA A C     1 ? 
ATOM   2517 O O     . ALA A 1 318 ? 14.493  11.065  10.103  1.000 10.120 0 318 ALA A O     1 ? 
ATOM   2518 C CB    . ALA A 1 318 ? 14.101  13.658  11.997  1.000 11.404 0 318 ALA A CB    1 ? 
ATOM   2519 N N     . ASP A 1 319 ? 15.290  10.665  12.165  1.000 11.319 0 319 ASP A N     1 ? 
ATOM   2520 C CA    . ASP A 1 319 ? 16.296  9.647   11.740  1.000 12.235 0 319 ASP A CA    1 ? 
ATOM   2521 C C     . ASP A 1 319 ? 15.628  8.432   11.065  1.000 11.726 0 319 ASP A C     1 ? 
ATOM   2522 O O     . ASP A 1 319 ? 16.313  7.744   10.295  1.000 10.460 0 319 ASP A O     1 ? 
ATOM   2523 C CB    . ASP A 1 319 ? 17.150  9.249   12.933  1.000 14.681 0 319 ASP A CB    1 ? 
ATOM   2524 C CG    . ASP A 1 319 ? 18.067  10.374  13.397  1.000 15.378 0 319 ASP A CG    1 ? 
ATOM   2525 O OD1   . ASP A 1 319 ? 18.536  10.280  14.507  1.000 17.046 0 319 ASP A OD1   1 ? 
ATOM   2526 O OD2   . ASP A 1 319 ? 18.295  11.324  12.617  1.000 17.181 0 319 ASP A OD2   1 ? 
ATOM   2527 N N     . HIS A 1 320 ? 14.335  8.168   11.320  1.000 10.992 0 320 HIS A N     1 ? 
ATOM   2528 C CA    . HIS A 1 320 ? 13.575  7.023   10.740  1.000 10.746 0 320 HIS A CA    1 ? 
ATOM   2529 C C     . HIS A 1 320 ? 12.522  7.493   9.733   1.000 10.662 0 320 HIS A C     1 ? 
ATOM   2530 O O     . HIS A 1 320 ? 12.220  6.735   8.843   1.000 10.739 0 320 HIS A O     1 ? 
ATOM   2531 C CB    . HIS A 1 320 ? 12.927  6.182   11.857  1.000 10.741 0 320 HIS A CB    1 ? 
ATOM   2532 C CG    . HIS A 1 320 ? 13.957  5.664   12.793  1.000 10.733 0 320 HIS A CG    1 ? 
ATOM   2533 N ND1   . HIS A 1 320 ? 14.568  4.462   12.592  1.000 10.738 0 320 HIS A ND1   1 ? 
ATOM   2534 C CD2   . HIS A 1 320 ? 14.598  6.260   13.823  1.000 10.809 0 320 HIS A CD2   1 ? 
ATOM   2535 C CE1   . HIS A 1 320 ? 15.509  4.310   13.516  1.000 12.527 0 320 HIS A CE1   1 ? 
ATOM   2536 N NE2   . HIS A 1 320 ? 15.542  5.400   14.282  1.000 10.569 0 320 HIS A NE2   1 ? 
ATOM   2537 N N     . PHE A 1 321 ? 12.018  8.727   9.844   1.000 11.394 0 321 PHE A N     1 ? 
ATOM   2538 C CA    . PHE A 1 321 ? 10.939  9.241   8.959   1.000 11.228 0 321 PHE A CA    1 ? 
ATOM   2539 C C     . PHE A 1 321 ? 11.445  10.187  7.862   1.000 12.085 0 321 PHE A C     1 ? 
ATOM   2540 O O     . PHE A 1 321 ? 10.646  10.417  6.911   1.000 13.384 0 321 PHE A O     1 ? 
ATOM   2541 C CB    . PHE A 1 321 ? 9.863   9.917   9.798   1.000 12.079 0 321 PHE A CB    1 ? 
ATOM   2542 C CG    . PHE A 1 321 ? 9.028   8.942   10.597  1.000 11.519 0 321 PHE A CG    1 ? 
ATOM   2543 C CD1   . PHE A 1 321 ? 8.330   7.897   9.974   1.000 11.341 0 321 PHE A CD1   1 ? 
ATOM   2544 C CD2   . PHE A 1 321 ? 8.957   9.049   11.962  1.000 11.667 0 321 PHE A CD2   1 ? 
ATOM   2545 C CE1   . PHE A 1 321 ? 7.574   7.005   10.716  1.000 11.939 0 321 PHE A CE1   1 ? 
ATOM   2546 C CE2   . PHE A 1 321 ? 8.209   8.151   12.707  1.000 12.170 0 321 PHE A CE2   1 ? 
ATOM   2547 C CZ    . PHE A 1 321 ? 7.511   7.138   12.089  1.000 12.421 0 321 PHE A CZ    1 ? 
ATOM   2548 N N     . GLY A 1 322 ? 12.655  10.746  7.983   1.000 12.370 0 322 GLY A N     1 ? 
ATOM   2549 C CA    . GLY A 1 322 ? 13.299  11.532  6.915   1.000 11.952 0 322 GLY A CA    1 ? 
ATOM   2550 C C     . GLY A 1 322 ? 13.013  13.018  7.068   1.000 11.499 0 322 GLY A C     1 ? 
ATOM   2551 O O     . GLY A 1 322 ? 12.612  13.444  8.146   1.000 10.362 0 322 GLY A O     1 ? 
ATOM   2552 N N     . SER A 1 323 ? 13.198  13.770  5.999   1.000 12.196 0 323 SER A N     1 ? 
ATOM   2553 C CA    . SER A 1 323 ? 13.415  15.231  6.036   1.000 13.837 0 323 SER A CA    1 ? 
ATOM   2554 C C     . SER A 1 323 ? 12.112  15.990  6.295   1.000 13.890 0 323 SER A C     1 ? 
ATOM   2555 O O     . SER A 1 323 ? 12.205  17.160  6.715   1.000 13.784 0 323 SER A O     1 ? 
ATOM   2556 C CB    . SER A 1 323 ? 14.083  15.647  4.759   1.000 15.805 0 323 SER A CB    1 ? 
ATOM   2557 O OG    . SER A 1 323 ? 13.192  15.455  3.694   1.000 18.770 0 323 SER A OG    1 ? 
ATOM   2558 N N     . GLU A 1 324 ? 10.931  15.361  6.135   1.000 13.537 0 324 GLU A N     1 ? 
ATOM   2559 C CA    . GLU A 1 324 ? 9.619   16.048  6.363   1.000 14.270 0 324 GLU A CA    1 ? 
ATOM   2560 C C     . GLU A 1 324 ? 9.219   15.986  7.826   1.000 12.848 0 324 GLU A C     1 ? 
ATOM   2561 O O     . GLU A 1 324 ? 8.254   16.636  8.158   1.000 13.499 0 324 GLU A O     1 ? 
ATOM   2562 C CB    . GLU A 1 324 ? 8.482   15.448  5.560   1.000 15.952 0 324 GLU A CB    1 ? 
ATOM   2563 C CG    . GLU A 1 324 ? 8.689   15.578  4.083   1.000 18.961 0 324 GLU A CG    1 ? 
ATOM   2564 C CD    . GLU A 1 324 ? 8.615   16.994  3.572   1.000 23.041 0 324 GLU A CD    1 ? 
ATOM   2565 O OE1   . GLU A 1 324 ? 8.919   17.175  2.385   1.000 26.422 0 324 GLU A OE1   1 ? 
ATOM   2566 O OE2   . GLU A 1 324 ? 8.212   17.921  4.371   1.000 24.820 0 324 GLU A OE2   1 ? 
ATOM   2567 N N     . PHE A 1 325 ? 9.912   15.207  8.664   1.000 11.002 0 325 PHE A N     1 ? 
ATOM   2568 C CA    . PHE A 1 325 ? 9.587   15.166  10.095  1.000 10.841 0 325 PHE A CA    1 ? 
ATOM   2569 C C     . PHE A 1 325 ? 10.128  16.429  10.754  1.000 10.554 0 325 PHE A C     1 ? 
ATOM   2570 O O     . PHE A 1 325 ? 11.330  16.667  10.755  1.000 10.596 0 325 PHE A O     1 ? 
ATOM   2571 C CB    . PHE A 1 325 ? 10.067  13.916  10.815  1.000 10.621 0 325 PHE A CB    1 ? 
ATOM   2572 C CG    . PHE A 1 325 ? 9.306   13.693  12.093  1.000 10.715 0 325 PHE A CG    1 ? 
ATOM   2573 C CD1   . PHE A 1 325 ? 9.629   14.390  13.245  1.000 11.133 0 325 PHE A CD1   1 ? 
ATOM   2574 C CD2   . PHE A 1 325 ? 8.200   12.856  12.119  1.000 11.388 0 325 PHE A CD2   1 ? 
ATOM   2575 C CE1   . PHE A 1 325 ? 8.881   14.234  14.408  1.000 11.286 0 325 PHE A CE1   1 ? 
ATOM   2576 C CE2   . PHE A 1 325 ? 7.461   12.691  13.279  1.000 10.756 0 325 PHE A CE2   1 ? 
ATOM   2577 C CZ    . PHE A 1 325 ? 7.813   13.345  14.427  1.000 11.082 0 325 PHE A CZ    1 ? 
ATOM   2578 N N     . PRO A 1 326 ? 9.249   17.310  11.278  1.000 11.806 0 326 PRO A N     1 ? 
ATOM   2579 C CA    . PRO A 1 326 ? 9.689   18.577  11.850  1.000 11.490 0 326 PRO A CA    1 ? 
ATOM   2580 C C     . PRO A 1 326 ? 10.592  18.372  13.066  1.000 11.423 0 326 PRO A C     1 ? 
ATOM   2581 O O     . PRO A 1 326 ? 10.250  17.611  13.945  1.000 11.855 0 326 PRO A O     1 ? 
ATOM   2582 C CB    . PRO A 1 326 ? 8.408   19.292  12.273  1.000 11.900 0 326 PRO A CB    1 ? 
ATOM   2583 C CG    . PRO A 1 326 ? 7.335   18.659  11.426  1.000 12.448 0 326 PRO A CG    1 ? 
ATOM   2584 C CD    . PRO A 1 326 ? 7.775   17.211  11.257  1.000 12.480 0 326 PRO A CD    1 ? 
ATOM   2585 N N     . VAL A 1 327 ? 11.696  19.106  13.127  1.000 12.426 0 327 VAL A N     1 ? 
ATOM   2586 C CA    . VAL A 1 327 ? 12.586  19.084  14.317  1.000 13.788 0 327 VAL A CA    1 ? 
ATOM   2587 C C     . VAL A 1 327 ? 12.652  20.499  14.898  1.000 14.913 0 327 VAL A C     1 ? 
ATOM   2588 O O     . VAL A 1 327 ? 13.405  21.359  14.419  1.000 13.305 0 327 VAL A O     1 ? 
ATOM   2589 C CB    . VAL A 1 327 ? 13.962  18.507  13.967  1.000 14.622 0 327 VAL A CB    1 ? 
ATOM   2590 C CG1   . VAL A 1 327 ? 14.870  18.437  15.186  1.000 15.316 0 327 VAL A CG1   1 ? 
ATOM   2591 C CG2   . VAL A 1 327 ? 13.827  17.136  13.324  1.000 16.955 0 327 VAL A CG2   1 ? 
ATOM   2592 N N     . PRO A 1 328 ? 11.861  20.801  15.944  1.000 16.182 0 328 PRO A N     1 ? 
ATOM   2593 C CA    . PRO A 1 328 ? 11.943  22.126  16.572  1.000 18.901 0 328 PRO A CA    1 ? 
ATOM   2594 C C     . PRO A 1 328 ? 13.354  22.410  17.128  1.000 20.637 0 328 PRO A C     1 ? 
ATOM   2595 O O     . PRO A 1 328 ? 14.007  21.489  17.587  1.000 16.064 0 328 PRO A O     1 ? 
ATOM   2596 C CB    . PRO A 1 328 ? 10.884  22.046  17.667  1.000 19.141 0 328 PRO A CB    1 ? 
ATOM   2597 C CG    . PRO A 1 328 ? 9.912   21.004  17.146  1.000 19.400 0 328 PRO A CG    1 ? 
ATOM   2598 C CD    . PRO A 1 328 ? 10.819  19.950  16.536  1.000 17.195 0 328 PRO A CD    1 ? 
ATOM   2599 N N     . GLU A 1 329 ? 13.804  23.669  17.025  1.000 25.227 0 329 GLU A N     1 ? 
ATOM   2600 C CA    . GLU A 1 329 ? 15.127  24.114  17.531  1.000 28.940 0 329 GLU A CA    1 ? 
ATOM   2601 C C     . GLU A 1 329 ? 15.129  24.002  19.051  1.000 29.182 0 329 GLU A C     1 ? 
ATOM   2602 O O     . GLU A 1 329 ? 14.124  24.372  19.649  1.000 34.395 0 329 GLU A O     1 ? 
ATOM   2603 C CB    . GLU A 1 329 ? 15.399  25.565  17.137  1.000 34.000 0 329 GLU A CB    1 ? 
ATOM   2604 C CG    . GLU A 1 329 ? 15.546  25.776  15.650  1.000 37.578 0 329 GLU A CG    1 ? 
ATOM   2605 C CD    . GLU A 1 329 ? 16.187  27.102  15.250  1.000 46.172 0 329 GLU A CD    1 ? 
ATOM   2606 O OE1   . GLU A 1 329 ? 16.468  27.944  16.153  1.000 54.512 0 329 GLU A OE1   1 ? 
ATOM   2607 O OE2   . GLU A 1 329 ? 16.423  27.295  14.037  1.000 56.469 0 329 GLU A OE2   1 ? 
ATOM   2608 N N     . LYS A 1 330 ? 16.229  23.549  19.640  1.000 33.294 0 330 LYS A N     1 ? 
ATOM   2609 C CA    . LYS A 1 330 ? 16.398  23.421  21.112  1.000 40.122 0 330 LYS A CA    1 ? 
ATOM   2610 C C     . LYS A 1 330 ? 16.327  24.813  21.754  1.000 41.634 0 330 LYS A C     1 ? 
ATOM   2611 O O     . LYS A 1 330 ? 17.063  25.723  21.343  1.000 42.113 0 330 LYS A O     1 ? 
ATOM   2612 C CB    . LYS A 1 330 ? 17.717  22.720  21.455  1.000 43.724 0 330 LYS A CB    1 ? 
ATOM   2613 C CG    . LYS A 1 330 ? 17.921  22.488  22.946  1.000 53.731 0 330 LYS A CG    1 ? 
ATOM   2614 C CD    . LYS A 1 330 ? 19.187  21.738  23.327  1.000 57.812 0 330 LYS A CD    1 ? 
ATOM   2615 C CE    . LYS A 1 330 ? 19.697  22.164  24.691  1.000 62.894 0 330 LYS A CE    1 ? 
ATOM   2616 N NZ    . LYS A 1 330 ? 20.649  21.187  25.272  1.000 65.955 0 330 LYS A NZ    1 ? 
HETATM 2617 P PA    . UTP B 2 .   ? 2.616   -7.723  -9.687  0.840 43.172 0 401 UTP A PA    1 ? 
HETATM 2618 O O1A   . UTP B 2 .   ? 2.304   -8.934  -8.883  0.840 45.720 0 401 UTP A O1A   1 ? 
HETATM 2619 O O2A   . UTP B 2 .   ? 2.303   -7.745  -11.146 0.840 39.164 0 401 UTP A O2A   1 ? 
HETATM 2620 O O3A   . UTP B 2 .   ? 4.183   -7.403  -9.535  0.840 56.528 0 401 UTP A O3A   1 ? 
HETATM 2621 O "O5'" . UTP B 2 .   ? 1.940   -6.440  -8.985  0.840 39.800 0 401 UTP A "O5'" 1 ? 
HETATM 2622 P PB    . UTP B 2 .   ? 5.346   -8.395  -10.006 0.840 67.527 0 401 UTP A PB    1 ? 
HETATM 2623 O O1B   . UTP B 2 .   ? 5.268   -8.580  -11.489 0.840 59.030 0 401 UTP A O1B   1 ? 
HETATM 2624 O O2B   . UTP B 2 .   ? 5.294   -9.593  -9.114  0.840 71.987 0 401 UTP A O2B   1 ? 
HETATM 2625 O O3B   . UTP B 2 .   ? 6.686   -7.581  -9.701  0.840 76.845 0 401 UTP A O3B   1 ? 
HETATM 2626 P PG    . UTP B 2 .   ? 8.129   -7.764  -10.421 0.840 92.112 0 401 UTP A PG    1 ? 
HETATM 2627 O O1G   . UTP B 2 .   ? 8.316   -6.535  -11.277 0.840 90.147 0 401 UTP A O1G   1 ? 
HETATM 2628 O O2G   . UTP B 2 .   ? 9.147   -7.861  -9.301  0.840 94.202 0 401 UTP A O2G   1 ? 
HETATM 2629 O O3G   . UTP B 2 .   ? 8.038   -9.039  -11.241 0.840 88.211 0 401 UTP A O3G   1 ? 
HETATM 2630 C "C5'" . UTP B 2 .   ? 2.007   -5.136  -9.611  0.840 40.715 0 401 UTP A "C5'" 1 ? 
HETATM 2631 C "C4'" . UTP B 2 .   ? 0.743   -4.375  -9.295  0.840 39.887 0 401 UTP A "C4'" 1 ? 
HETATM 2632 O "O4'" . UTP B 2 .   ? -0.411  -5.193  -9.603  0.840 37.708 0 401 UTP A "O4'" 1 ? 
HETATM 2633 C "C1'" . UTP B 2 .   ? -1.533  -4.710  -8.881  0.840 37.197 0 401 UTP A "C1'" 1 ? 
HETATM 2634 C "C2'" . UTP B 2 .   ? -1.007  -3.696  -7.848  0.840 37.003 0 401 UTP A "C2'" 1 ? 
HETATM 2635 O "O2'" . UTP B 2 .   ? -1.259  -2.379  -8.296  0.840 34.691 0 401 UTP A "O2'" 1 ? 
HETATM 2636 C "C3'" . UTP B 2 .   ? 0.499   -4.006  -7.824  0.840 38.313 0 401 UTP A "C3'" 1 ? 
HETATM 2637 O "O3'" . UTP B 2 .   ? 1.267   -2.882  -7.409  0.840 37.484 0 401 UTP A "O3'" 1 ? 
HETATM 2638 N N1    . UTP B 2 .   ? -2.234  -5.860  -8.247  0.840 31.462 0 401 UTP A N1    1 ? 
HETATM 2639 C C6    . UTP B 2 .   ? -1.524  -6.899  -7.691  0.840 27.571 0 401 UTP A C6    1 ? 
HETATM 2640 C C2    . UTP B 2 .   ? -3.615  -5.782  -8.110  0.840 27.931 0 401 UTP A C2    1 ? 
HETATM 2641 O O2    . UTP B 2 .   ? -4.286  -4.850  -8.526  0.840 27.003 0 401 UTP A O2    1 ? 
HETATM 2642 N N3    . UTP B 2 .   ? -4.186  -6.835  -7.455  0.840 25.421 0 401 UTP A N3    1 ? 
HETATM 2643 C C4    . UTP B 2 .   ? -3.546  -7.941  -6.935  0.840 25.714 0 401 UTP A C4    1 ? 
HETATM 2644 O O4    . UTP B 2 .   ? -4.211  -8.810  -6.377  0.840 26.367 0 401 UTP A O4    1 ? 
HETATM 2645 C C5    . UTP B 2 .   ? -2.120  -7.937  -7.084  0.840 26.924 0 401 UTP A C5    1 ? 
HETATM 2646 P PA    . UTP C 2 .   ? -0.518  -1.742  -4.396  0.840 33.303 0 402 UTP A PA    1 ? 
HETATM 2647 O O1A   . UTP C 2 .   ? 0.642   -2.671  -4.271  0.840 34.974 0 402 UTP A O1A   1 ? 
HETATM 2648 O O2A   . UTP C 2 .   ? -0.499  -0.626  -5.390  0.840 32.532 0 402 UTP A O2A   1 ? 
HETATM 2649 O O3A   . UTP C 2 .   ? -0.846  -1.179  -2.938  0.840 34.740 0 402 UTP A O3A   1 ? 
HETATM 2650 O "O5'" . UTP C 2 .   ? -1.824  -2.619  -4.609  0.840 34.496 0 402 UTP A "O5'" 1 ? 
HETATM 2651 P PB    . UTP C 2 .   ? -1.443  0.160   -2.341  0.840 33.167 0 402 UTP A PB    1 ? 
HETATM 2652 O O1B   . UTP C 2 .   ? -2.508  -0.225  -1.329  0.840 32.429 0 402 UTP A O1B   1 ? 
HETATM 2653 O O2B   . UTP C 2 .   ? -1.814  1.070   -3.477  0.840 33.158 0 402 UTP A O2B   1 ? 
HETATM 2654 O O3B   . UTP C 2 .   ? -0.143  0.733   -1.574  0.840 42.543 0 402 UTP A O3B   1 ? 
HETATM 2655 P PG    . UTP C 2 .   ? 0.869   1.991   -1.953  0.840 43.915 0 402 UTP A PG    1 ? 
HETATM 2656 O O1G   . UTP C 2 .   ? 2.253   1.773   -1.341  0.840 42.959 0 402 UTP A O1G   1 ? 
HETATM 2657 O O2G   . UTP C 2 .   ? 0.881   1.961   -3.478  0.840 40.295 0 402 UTP A O2G   1 ? 
HETATM 2658 O O3G   . UTP C 2 .   ? 0.218   3.250   -1.411  0.840 46.152 0 402 UTP A O3G   1 ? 
HETATM 2659 C "C5'" . UTP C 2 .   ? -2.997  -2.115  -5.264  0.840 35.155 0 402 UTP A "C5'" 1 ? 
HETATM 2660 C "C4'" . UTP C 2 .   ? -4.132  -3.008  -4.844  0.840 33.591 0 402 UTP A "C4'" 1 ? 
HETATM 2661 O "O4'" . UTP C 2 .   ? -4.005  -4.312  -5.483  0.840 33.288 0 402 UTP A "O4'" 1 ? 
HETATM 2662 C "C1'" . UTP C 2 .   ? -4.401  -5.327  -4.568  0.840 33.709 0 402 UTP A "C1'" 1 ? 
HETATM 2663 C "C2'" . UTP C 2 .   ? -5.003  -4.608  -3.356  0.840 33.565 0 402 UTP A "C2'" 1 ? 
HETATM 2664 O "O2'" . UTP C 2 .   ? -6.372  -4.342  -3.564  0.840 29.616 0 402 UTP A "O2'" 1 ? 
HETATM 2665 C "C3'" . UTP C 2 .   ? -4.142  -3.336  -3.345  0.840 34.078 0 402 UTP A "C3'" 1 ? 
HETATM 2666 O "O3'" . UTP C 2 .   ? -4.620  -2.210  -2.617  0.840 33.028 0 402 UTP A "O3'" 1 ? 
HETATM 2667 N N1    . UTP C 2 .   ? -3.225  -6.153  -4.187  0.840 34.893 0 402 UTP A N1    1 ? 
HETATM 2668 C C6    . UTP C 2 .   ? -1.932  -5.696  -4.347  0.840 36.368 0 402 UTP A C6    1 ? 
HETATM 2669 C C2    . UTP C 2 .   ? -3.472  -7.391  -3.610  0.840 33.320 0 402 UTP A C2    1 ? 
HETATM 2670 O O2    . UTP C 2 .   ? -4.594  -7.843  -3.459  0.840 32.187 0 402 UTP A O2    1 ? 
HETATM 2671 N N3    . UTP C 2 .   ? -2.357  -8.105  -3.253  0.840 34.000 0 402 UTP A N3    1 ? 
HETATM 2672 C C4    . UTP C 2 .   ? -1.039  -7.710  -3.378  0.840 39.303 0 402 UTP A C4    1 ? 
HETATM 2673 O O4    . UTP C 2 .   ? -0.143  -8.462  -2.985  0.840 44.505 0 402 UTP A O4    1 ? 
HETATM 2674 C C5    . UTP C 2 .   ? -0.857  -6.415  -3.972  0.840 37.075 0 402 UTP A C5    1 ? 
HETATM 2675 O O     . HOH D 3 .   ? -19.398 -3.774  3.982   1.000 20.811 0 501 HOH A O     1 ? 
HETATM 2676 O O     . HOH D 3 .   ? 0.424   -0.511  -7.813  1.000 13.484 0 502 HOH A O     1 ? 
HETATM 2677 O O     . HOH D 3 .   ? 6.845   8.440   0.619   1.000 25.681 0 503 HOH A O     1 ? 
HETATM 2678 O O     . HOH D 3 .   ? -10.165 8.307   25.850  1.000 42.592 0 504 HOH A O     1 ? 
HETATM 2679 O O     . HOH D 3 .   ? -16.404 -7.847  -3.146  1.000 37.567 0 505 HOH A O     1 ? 
HETATM 2680 O O     . HOH D 3 .   ? 2.605   8.857   24.884  1.000 28.135 0 506 HOH A O     1 ? 
HETATM 2681 O O     . HOH D 3 .   ? -12.691 -2.323  14.420  1.000 32.752 0 507 HOH A O     1 ? 
HETATM 2682 O O     . HOH D 3 .   ? -0.836  -17.492 7.697   1.000 40.986 0 508 HOH A O     1 ? 
HETATM 2683 O O     . HOH D 3 .   ? -10.173 20.183  27.675  1.000 35.026 0 509 HOH A O     1 ? 
HETATM 2684 O O     . HOH D 3 .   ? -17.886 -11.870 -32.507 1.000 38.147 0 510 HOH A O     1 ? 
HETATM 2685 O O     . HOH D 3 .   ? -16.759 3.758   14.929  1.000 23.660 0 511 HOH A O     1 ? 
HETATM 2686 O O     . HOH D 3 .   ? -6.137  -10.243 -5.833  1.000 33.709 0 512 HOH A O     1 ? 
HETATM 2687 O O     . HOH D 3 .   ? 23.786  -27.753 8.896   1.000 37.560 0 513 HOH A O     1 ? 
HETATM 2688 O O     . HOH D 3 .   ? -10.865 20.451  30.889  1.000 44.117 0 514 HOH A O     1 ? 
HETATM 2689 O O     . HOH D 3 .   ? 12.684  4.718   -1.406  1.000 22.152 0 515 HOH A O     1 ? 
HETATM 2690 O O     . HOH D 3 .   ? 16.606  15.605  25.489  1.000 29.916 0 516 HOH A O     1 ? 
HETATM 2691 O O     . HOH D 3 .   ? -5.398  18.124  -8.184  1.000 35.988 0 517 HOH A O     1 ? 
HETATM 2692 O O     . HOH D 3 .   ? -3.984  -17.628 -1.255  1.000 27.209 0 518 HOH A O     1 ? 
HETATM 2693 O O     . HOH D 3 .   ? -13.202 -1.391  -24.590 1.000 34.040 0 519 HOH A O     1 ? 
HETATM 2694 O O     . HOH D 3 .   ? 22.181  -12.668 8.976   1.000 16.271 0 520 HOH A O     1 ? 
HETATM 2695 O O     . HOH D 3 .   ? -14.530 -11.574 -5.167  1.000 32.436 0 521 HOH A O     1 ? 
HETATM 2696 O O     . HOH D 3 .   ? 2.713   -13.100 -3.667  1.000 42.921 0 522 HOH A O     1 ? 
HETATM 2697 O O     . HOH D 3 .   ? -16.309 7.801   15.072  1.000 20.801 0 523 HOH A O     1 ? 
HETATM 2698 O O     . HOH D 3 .   ? -7.084  -8.434  14.489  1.000 29.359 0 524 HOH A O     1 ? 
HETATM 2699 O O     . HOH D 3 .   ? 7.390   19.169  2.065   1.000 39.040 0 525 HOH A O     1 ? 
HETATM 2700 O O     . HOH D 3 .   ? -6.170  -12.647 -6.502  1.000 33.475 0 526 HOH A O     1 ? 
HETATM 2701 O O     . HOH D 3 .   ? 3.973   -17.166 3.709   1.000 33.985 0 527 HOH A O     1 ? 
HETATM 2702 O O     . HOH D 3 .   ? -7.918  18.363  -7.153  1.000 37.650 0 528 HOH A O     1 ? 
HETATM 2703 O O     . HOH D 3 .   ? -12.458 9.052   9.174   1.000 15.829 0 529 HOH A O     1 ? 
HETATM 2704 O O     . HOH D 3 .   ? 18.484  26.440  23.353  1.000 41.141 0 530 HOH A O     1 ? 
HETATM 2705 O O     . HOH D 3 .   ? 20.703  11.584  14.931  1.000 16.120 0 531 HOH A O     1 ? 
HETATM 2706 O O     . HOH D 3 .   ? -3.366  -10.858 -3.291  1.000 28.359 0 532 HOH A O     1 ? 
HETATM 2707 O O     . HOH D 3 .   ? 9.096   -4.157  -2.358  1.000 35.809 0 533 HOH A O     1 ? 
HETATM 2708 O O     . HOH D 3 .   ? -1.584  3.834   -5.098  1.000 22.352 0 534 HOH A O     1 ? 
HETATM 2709 O O     . HOH D 3 .   ? 18.686  1.135   11.528  1.000 32.438 0 535 HOH A O     1 ? 
HETATM 2710 O O     . HOH D 3 .   ? -2.471  13.500  22.689  1.000 30.631 0 536 HOH A O     1 ? 
HETATM 2711 O O     . HOH D 3 .   ? -11.534 13.956  18.015  1.000 20.768 0 537 HOH A O     1 ? 
HETATM 2712 O O     . HOH D 3 .   ? -7.399  12.533  0.824   1.000 18.958 0 538 HOH A O     1 ? 
HETATM 2713 O O     . HOH D 3 .   ? 0.999   16.812  1.610   1.000 19.743 0 539 HOH A O     1 ? 
HETATM 2714 O O     . HOH D 3 .   ? -6.817  -6.761  -7.002  1.000 23.109 0 540 HOH A O     1 ? 
HETATM 2715 O O     . HOH D 3 .   ? -15.903 -9.258  0.603   1.000 26.925 0 541 HOH A O     1 ? 
HETATM 2716 O O     . HOH D 3 .   ? -16.110 -19.821 -15.167 1.000 47.584 0 542 HOH A O     1 ? 
HETATM 2717 O O     . HOH D 3 .   ? -1.573  0.868   17.750  1.000 9.335  0 543 HOH A O     1 ? 
HETATM 2718 O O     . HOH D 3 .   ? 16.564  7.381   1.790   1.000 28.385 0 544 HOH A O     1 ? 
HETATM 2719 O O     . HOH D 3 .   ? -10.804 -10.206 9.373   1.000 24.404 0 545 HOH A O     1 ? 
HETATM 2720 O O     . HOH D 3 .   ? 4.015   4.803   24.795  1.000 18.331 0 546 HOH A O     1 ? 
HETATM 2721 O O     . HOH D 3 .   ? -5.346  9.053   -23.532 1.000 31.602 0 547 HOH A O     1 ? 
HETATM 2722 O O     . HOH D 3 .   ? 13.484  15.994  9.440   1.000 13.346 0 548 HOH A O     1 ? 
HETATM 2723 O O     . HOH D 3 .   ? 20.518  -29.778 9.947   1.000 25.311 0 549 HOH A O     1 ? 
HETATM 2724 O O     . HOH D 3 .   ? -2.601  1.546   1.510   1.000 23.518 0 550 HOH A O     1 ? 
HETATM 2725 O O     . HOH D 3 .   ? 6.640   12.111  26.007  1.000 36.363 0 551 HOH A O     1 ? 
HETATM 2726 O O     . HOH D 3 .   ? 17.781  -11.759 -0.050  1.000 21.191 0 552 HOH A O     1 ? 
HETATM 2727 O O     . HOH D 3 .   ? 3.759   -14.043 11.224  1.000 19.026 0 553 HOH A O     1 ? 
HETATM 2728 O O     . HOH D 3 .   ? 7.047   -18.297 9.608   1.000 22.875 0 554 HOH A O     1 ? 
HETATM 2729 O O     . HOH D 3 .   ? 1.690   -14.605 14.376  1.000 27.053 0 555 HOH A O     1 ? 
HETATM 2730 O O     . HOH D 3 .   ? 4.552   18.194  1.256   1.000 27.530 0 556 HOH A O     1 ? 
HETATM 2731 O O     . HOH D 3 .   ? -9.705  -19.620 -19.090 1.000 34.807 0 557 HOH A O     1 ? 
HETATM 2732 O O     . HOH D 3 .   ? 13.908  -5.640  4.095   1.000 15.673 0 558 HOH A O     1 ? 
HETATM 2733 O O     . HOH D 3 .   ? -15.736 -9.906  -39.093 1.000 31.150 0 559 HOH A O     1 ? 
HETATM 2734 O O     . HOH D 3 .   ? 17.584  -22.100 13.617  1.000 24.602 0 560 HOH A O     1 ? 
HETATM 2735 O O     . HOH D 3 .   ? -3.421  -18.044 -11.585 1.000 42.231 0 561 HOH A O     1 ? 
HETATM 2736 O O     . HOH D 3 .   ? -11.566 3.814   19.684  1.000 37.434 0 562 HOH A O     1 ? 
HETATM 2737 O O     . HOH D 3 .   ? 16.460  -8.917  12.752  1.000 22.137 0 563 HOH A O     1 ? 
HETATM 2738 O O     . HOH D 3 .   ? 15.313  -23.669 1.666   1.000 33.966 0 564 HOH A O     1 ? 
HETATM 2739 O O     . HOH D 3 .   ? -13.477 5.266   6.816   1.000 26.895 0 565 HOH A O     1 ? 
HETATM 2740 O O     . HOH D 3 .   ? 6.747   21.813  15.083  1.000 18.511 0 566 HOH A O     1 ? 
HETATM 2741 O O     . HOH D 3 .   ? -9.951  3.916   4.029   1.000 13.002 0 567 HOH A O     1 ? 
HETATM 2742 O O     . HOH D 3 .   ? -4.789  9.247   -0.169  1.000 23.255 0 568 HOH A O     1 ? 
HETATM 2743 O O     . HOH D 3 .   ? 5.337   -10.317 -1.164  1.000 29.483 0 569 HOH A O     1 ? 
HETATM 2744 O O     . HOH D 3 .   ? -7.246  1.254   21.552  1.000 28.698 0 570 HOH A O     1 ? 
HETATM 2745 O O     . HOH D 3 .   ? -15.688 13.893  23.571  1.000 30.780 0 571 HOH A O     1 ? 
HETATM 2746 O O     . HOH D 3 .   ? -10.883 -11.844 7.185   1.000 19.987 0 572 HOH A O     1 ? 
HETATM 2747 O O     . HOH D 3 .   ? -3.651  18.051  27.564  1.000 34.861 0 573 HOH A O     1 ? 
HETATM 2748 O O     . HOH D 3 .   ? 18.875  8.166   9.622   1.000 16.026 0 574 HOH A O     1 ? 
HETATM 2749 O O     . HOH D 3 .   ? 6.453   2.477   -25.733 1.000 48.467 0 575 HOH A O     1 ? 
HETATM 2750 O O     . HOH D 3 .   ? -10.499 -1.037  -4.426  1.000 27.053 0 576 HOH A O     1 ? 
HETATM 2751 O O     . HOH D 3 .   ? -12.254 11.489  18.671  1.000 40.084 0 577 HOH A O     1 ? 
HETATM 2752 O O     . HOH D 3 .   ? -11.391 6.402   0.510   1.000 31.768 0 578 HOH A O     1 ? 
HETATM 2753 O O     . HOH D 3 .   ? -14.257 -12.841 -13.050 1.000 22.704 0 579 HOH A O     1 ? 
HETATM 2754 O O     . HOH D 3 .   ? 11.193  -22.965 11.643  1.000 25.744 0 580 HOH A O     1 ? 
HETATM 2755 O O     . HOH D 3 .   ? -11.177 8.571   -3.446  1.000 24.401 0 581 HOH A O     1 ? 
HETATM 2756 O O     . HOH D 3 .   ? -6.535  -9.292  -32.610 1.000 36.109 0 582 HOH A O     1 ? 
HETATM 2757 O O     . HOH D 3 .   ? -8.300  -0.950  15.909  1.000 17.787 0 583 HOH A O     1 ? 
HETATM 2758 O O     . HOH D 3 .   ? 16.673  3.482   17.048  1.000 13.653 0 584 HOH A O     1 ? 
HETATM 2759 O O     . HOH D 3 .   ? -11.348 2.553   9.015   1.000 12.941 0 585 HOH A O     1 ? 
HETATM 2760 O O     . HOH D 3 .   ? 11.587  -2.462  23.644  1.000 38.036 0 586 HOH A O     1 ? 
HETATM 2761 O O     . HOH D 3 .   ? -16.296 -2.758  10.972  1.000 25.051 0 587 HOH A O     1 ? 
HETATM 2762 O O     . HOH D 3 .   ? 20.664  18.218  22.066  1.000 34.774 0 588 HOH A O     1 ? 
HETATM 2763 O O     . HOH D 3 .   ? 4.917   18.578  20.743  1.000 18.501 0 589 HOH A O     1 ? 
HETATM 2764 O O     . HOH D 3 .   ? -9.146  15.453  18.610  1.000 21.358 0 590 HOH A O     1 ? 
HETATM 2765 O O     . HOH D 3 .   ? -13.120 -12.122 -0.341  1.000 19.448 0 591 HOH A O     1 ? 
HETATM 2766 O O     . HOH D 3 .   ? 6.123   -13.687 4.989   1.000 17.905 0 592 HOH A O     1 ? 
HETATM 2767 O O     . HOH D 3 .   ? 10.351  12.429  5.110   1.000 10.412 0 593 HOH A O     1 ? 
HETATM 2768 O O     . HOH D 3 .   ? 13.731  -7.463  17.307  1.000 23.108 0 594 HOH A O     1 ? 
HETATM 2769 O O     . HOH D 3 .   ? -1.272  19.957  11.535  1.000 22.526 0 595 HOH A O     1 ? 
HETATM 2770 O O     . HOH D 3 .   ? -7.968  -9.519  -3.572  1.000 20.309 0 596 HOH A O     1 ? 
HETATM 2771 O O     . HOH D 3 .   ? 18.780  5.761   7.706   1.000 29.333 0 597 HOH A O     1 ? 
HETATM 2772 O O     . HOH D 3 .   ? -1.294  -1.926  18.026  1.000 13.071 0 598 HOH A O     1 ? 
HETATM 2773 O O     . HOH D 3 .   ? 1.334   -13.459 11.541  1.000 39.345 0 599 HOH A O     1 ? 
HETATM 2774 O O     . HOH D 3 .   ? 6.349   14.762  1.109   1.000 17.855 0 600 HOH A O     1 ? 
HETATM 2775 O O     . HOH D 3 .   ? 16.107  21.713  14.211  1.000 24.521 0 601 HOH A O     1 ? 
HETATM 2776 O O     . HOH D 3 .   ? 17.649  -2.924  15.286  1.000 21.566 0 602 HOH A O     1 ? 
HETATM 2777 O O     . HOH D 3 .   ? -3.504  -5.602  -39.131 1.000 39.146 0 603 HOH A O     1 ? 
HETATM 2778 O O     . HOH D 3 .   ? 9.741   5.398   26.601  1.000 25.038 0 604 HOH A O     1 ? 
HETATM 2779 O O     . HOH D 3 .   ? 12.185  -17.063 -19.129 1.000 39.639 0 605 HOH A O     1 ? 
HETATM 2780 O O     . HOH D 3 .   ? 14.069  2.121   11.120  1.000 10.886 0 606 HOH A O     1 ? 
HETATM 2781 O O     . HOH D 3 .   ? -13.400 0.946   -5.916  1.000 23.519 0 607 HOH A O     1 ? 
HETATM 2782 O O     . HOH D 3 .   ? -7.216  -7.088  -3.163  1.000 36.964 0 608 HOH A O     1 ? 
HETATM 2783 O O     . HOH D 3 .   ? 8.474   20.647  4.556   1.000 26.781 0 609 HOH A O     1 ? 
HETATM 2784 O O     . HOH D 3 .   ? -13.106 -3.867  8.679   1.000 17.443 0 610 HOH A O     1 ? 
HETATM 2785 O O     . HOH D 3 .   ? 9.126   13.803  24.687  1.000 34.441 0 611 HOH A O     1 ? 
HETATM 2786 O O     . HOH D 3 .   ? 3.613   10.700  22.811  1.000 30.073 0 612 HOH A O     1 ? 
HETATM 2787 O O     . HOH D 3 .   ? -2.551  16.008  -2.067  1.000 32.872 0 613 HOH A O     1 ? 
HETATM 2788 O O     . HOH D 3 .   ? 5.562   -16.175 9.850   1.000 25.447 0 614 HOH A O     1 ? 
HETATM 2789 O O     . HOH D 3 .   ? 16.560  7.325   16.251  1.000 15.920 0 615 HOH A O     1 ? 
HETATM 2790 O O     . HOH D 3 .   ? 17.895  12.642  19.461  1.000 17.690 0 616 HOH A O     1 ? 
HETATM 2791 O O     . HOH D 3 .   ? 2.163   11.711  19.417  1.000 12.199 0 617 HOH A O     1 ? 
HETATM 2792 O O     . HOH D 3 .   ? -7.297  11.664  14.556  1.000 12.334 0 618 HOH A O     1 ? 
HETATM 2793 O O     . HOH D 3 .   ? 14.885  -16.858 2.001   1.000 24.099 0 619 HOH A O     1 ? 
HETATM 2794 O O     . HOH D 3 .   ? 18.323  1.175   2.400   1.000 28.634 0 620 HOH A O     1 ? 
HETATM 2795 O O     . HOH D 3 .   ? 10.817  -4.041  21.795  1.000 25.515 0 621 HOH A O     1 ? 
HETATM 2796 O O     . HOH D 3 .   ? -12.509 16.888  21.621  1.000 25.344 0 622 HOH A O     1 ? 
HETATM 2797 O O     . HOH D 3 .   ? 0.243   -17.053 0.998   1.000 18.726 0 623 HOH A O     1 ? 
HETATM 2798 O O     . HOH D 3 .   ? 9.923   -17.595 16.410  1.000 31.879 0 624 HOH A O     1 ? 
HETATM 2799 O O     . HOH D 3 .   ? -12.879 13.951  -12.566 1.000 40.095 0 625 HOH A O     1 ? 
HETATM 2800 O O     . HOH D 3 .   ? -8.901  -18.563 -7.772  1.000 32.236 0 626 HOH A O     1 ? 
HETATM 2801 O O     . HOH D 3 .   ? -10.745 2.167   1.922   1.000 15.236 0 627 HOH A O     1 ? 
HETATM 2802 O O     . HOH D 3 .   ? -6.614  -4.308  15.369  1.000 21.278 0 628 HOH A O     1 ? 
HETATM 2803 O O     . HOH D 3 .   ? -15.779 -14.057 -23.616 1.000 33.345 0 629 HOH A O     1 ? 
HETATM 2804 O O     . HOH D 3 .   ? 12.030  -10.139 -2.751  1.000 39.109 0 630 HOH A O     1 ? 
HETATM 2805 O O     . HOH D 3 .   ? 18.093  -13.082 12.806  1.000 34.163 0 631 HOH A O     1 ? 
HETATM 2806 O O     . HOH D 3 .   ? -2.246  15.940  10.230  1.000 10.832 0 632 HOH A O     1 ? 
HETATM 2807 O O     . HOH D 3 .   ? 6.997   3.490   25.948  1.000 41.437 0 633 HOH A O     1 ? 
HETATM 2808 O O     . HOH D 3 .   ? 18.331  2.102   5.393   1.000 27.821 0 634 HOH A O     1 ? 
HETATM 2809 O O     . HOH D 3 .   ? -20.636 -16.829 -19.842 1.000 30.960 0 635 HOH A O     1 ? 
HETATM 2810 O O     . HOH D 3 .   ? 10.614  -6.560  19.935  1.000 18.988 0 636 HOH A O     1 ? 
HETATM 2811 O O     . HOH D 3 .   ? 9.183   7.526   -2.956  1.000 34.140 0 637 HOH A O     1 ? 
HETATM 2812 O O     . HOH D 3 .   ? -3.428  -5.334  18.090  1.000 25.582 0 638 HOH A O     1 ? 
HETATM 2813 O O     . HOH D 3 .   ? -12.321 12.334  10.735  1.000 37.676 0 639 HOH A O     1 ? 
HETATM 2814 O O     . HOH D 3 .   ? -14.225 -16.920 1.450   1.000 33.016 0 640 HOH A O     1 ? 
HETATM 2815 O O     . HOH D 3 .   ? 0.090   19.954  14.143  1.000 23.789 0 641 HOH A O     1 ? 
HETATM 2816 O O     . HOH D 3 .   ? -9.989  4.418   6.976   1.000 19.008 0 642 HOH A O     1 ? 
HETATM 2817 O O     . HOH D 3 .   ? -4.262  3.982   -6.036  1.000 23.300 0 643 HOH A O     1 ? 
HETATM 2818 O O     . HOH D 3 .   ? -15.537 0.137   14.039  1.000 29.530 0 644 HOH A O     1 ? 
HETATM 2819 O O     . HOH D 3 .   ? 12.407  12.779  3.290   1.000 27.290 0 645 HOH A O     1 ? 
HETATM 2820 O O     . HOH D 3 .   ? -3.418  8.136   24.367  1.000 31.139 0 646 HOH A O     1 ? 
HETATM 2821 O O     . HOH D 3 .   ? -7.888  -1.847  -4.205  1.000 27.364 0 647 HOH A O     1 ? 
HETATM 2822 O O     . HOH D 3 .   ? 17.188  -15.032 2.279   1.000 20.537 0 648 HOH A O     1 ? 
HETATM 2823 O O     . HOH D 3 .   ? 13.638  21.295  22.627  1.000 22.519 0 649 HOH A O     1 ? 
HETATM 2824 O O     . HOH D 3 .   ? -1.427  9.346   25.485  1.000 23.514 0 650 HOH A O     1 ? 
HETATM 2825 O O     . HOH D 3 .   ? 11.426  -13.802 14.762  1.000 20.195 0 651 HOH A O     1 ? 
HETATM 2826 O O     . HOH D 3 .   ? -4.422  -8.528  -13.950 1.000 23.960 0 652 HOH A O     1 ? 
HETATM 2827 O O     . HOH D 3 .   ? 19.626  -4.481  8.306   1.000 29.957 0 653 HOH A O     1 ? 
HETATM 2828 O O     . HOH D 3 .   ? 0.907   6.006   -1.645  1.000 14.897 0 654 HOH A O     1 ? 
HETATM 2829 O O     . HOH D 3 .   ? -8.639  0.834   18.273  1.000 15.104 0 655 HOH A O     1 ? 
HETATM 2830 O O     . HOH D 3 .   ? -1.661  -12.292 15.240  1.000 38.994 0 656 HOH A O     1 ? 
HETATM 2831 O O     . HOH D 3 .   ? -10.868 -13.775 -35.585 1.000 12.052 0 657 HOH A O     1 ? 
HETATM 2832 O O     . HOH D 3 .   ? -7.595  14.896  26.105  1.000 29.489 0 658 HOH A O     1 ? 
HETATM 2833 O O     . HOH D 3 .   ? 6.095   -16.487 5.932   1.000 33.763 0 659 HOH A O     1 ? 
HETATM 2834 O O     . HOH D 3 .   ? -12.724 8.967   -8.404  1.000 31.872 0 660 HOH A O     1 ? 
HETATM 2835 O O     . HOH D 3 .   ? 13.071  -18.929 6.292   1.000 21.519 0 661 HOH A O     1 ? 
HETATM 2836 O O     . HOH D 3 .   ? 17.111  -3.277  20.088  1.000 32.676 0 662 HOH A O     1 ? 
HETATM 2837 O O     . HOH D 3 .   ? 11.557  20.739  25.185  1.000 27.831 0 663 HOH A O     1 ? 
HETATM 2838 O O     . HOH D 3 .   ? -13.370 9.800   21.038  1.000 26.578 0 664 HOH A O     1 ? 
HETATM 2839 O O     . HOH D 3 .   ? -6.740  10.346  5.734   1.000 20.553 0 665 HOH A O     1 ? 
HETATM 2840 O O     . HOH D 3 .   ? -14.259 3.215   -8.128  1.000 31.347 0 666 HOH A O     1 ? 
HETATM 2841 O O     . HOH D 3 .   ? 1.979   -3.418  21.551  1.000 33.113 0 667 HOH A O     1 ? 
HETATM 2842 O O     . HOH D 3 .   ? 15.910  -1.648  1.066   1.000 27.068 0 668 HOH A O     1 ? 
HETATM 2843 O O     . HOH D 3 .   ? -7.033  -13.885 6.206   1.000 22.197 0 669 HOH A O     1 ? 
HETATM 2844 O O     . HOH D 3 .   ? 15.615  -16.451 12.736  1.000 29.234 0 670 HOH A O     1 ? 
HETATM 2845 O O     . HOH D 3 .   ? -5.898  10.622  8.255   1.000 12.284 0 671 HOH A O     1 ? 
HETATM 2846 O O     . HOH D 3 .   ? -18.391 -6.353  -24.495 1.000 33.217 0 672 HOH A O     1 ? 
HETATM 2847 O O     . HOH D 3 .   ? -16.392 2.667   -31.282 1.000 44.889 0 673 HOH A O     1 ? 
HETATM 2848 O O     . HOH D 3 .   ? 12.642  -17.192 4.505   1.000 23.497 0 674 HOH A O     1 ? 
HETATM 2849 O O     . HOH D 3 .   ? -13.573 8.308   16.093  1.000 20.525 0 675 HOH A O     1 ? 
HETATM 2850 O O     . HOH D 3 .   ? -13.964 -6.715  -5.253  1.000 18.705 0 676 HOH A O     1 ? 
HETATM 2851 O O     . HOH D 3 .   ? -12.543 3.423   0.520   1.000 28.493 0 677 HOH A O     1 ? 
HETATM 2852 O O     . HOH D 3 .   ? -11.006 16.947  -6.342  1.000 43.877 0 678 HOH A O     1 ? 
HETATM 2853 O O     . HOH D 3 .   ? 4.550   -0.367  -2.070  1.000 27.449 0 679 HOH A O     1 ? 
HETATM 2854 O O     . HOH D 3 .   ? 16.655  12.407  8.614   1.000 21.117 0 680 HOH A O     1 ? 
HETATM 2855 O O     . HOH D 3 .   ? -0.531  -10.162 18.077  1.000 26.443 0 681 HOH A O     1 ? 
HETATM 2856 O O     . HOH D 3 .   ? -14.627 6.929   18.433  1.000 37.329 0 682 HOH A O     1 ? 
HETATM 2857 O O     . HOH D 3 .   ? 21.869  -30.122 6.151   1.000 43.541 0 683 HOH A O     1 ? 
HETATM 2858 O O     . HOH D 3 .   ? -20.414 -10.166 -23.437 1.000 47.186 0 684 HOH A O     1 ? 
HETATM 2859 O O     . HOH D 3 .   ? 23.949  -16.146 7.133   1.000 32.384 0 685 HOH A O     1 ? 
HETATM 2860 O O     . HOH D 3 .   ? 3.551   23.295  9.634   1.000 21.670 0 686 HOH A O     1 ? 
HETATM 2861 O O     . HOH D 3 .   ? 1.621   21.534  8.902   1.000 29.636 0 687 HOH A O     1 ? 
HETATM 2862 O O     . HOH D 3 .   ? -9.847  -5.631  11.982  1.000 22.623 0 688 HOH A O     1 ? 
HETATM 2863 O O     . HOH D 3 .   ? -6.687  4.887   23.581  1.000 23.749 0 689 HOH A O     1 ? 
HETATM 2864 O O     . HOH D 3 .   ? 21.005  17.906  18.280  1.000 38.708 0 690 HOH A O     1 ? 
HETATM 2865 O O     . HOH D 3 .   ? -13.736 9.723   23.616  1.000 35.750 0 691 HOH A O     1 ? 
HETATM 2866 O O     . HOH D 3 .   ? 13.108  -22.485 13.525  1.000 45.702 0 692 HOH A O     1 ? 
HETATM 2867 O O     . HOH D 3 .   ? 12.448  -21.237 4.125   1.000 35.656 0 693 HOH A O     1 ? 
HETATM 2868 O O     . HOH D 3 .   ? -14.034 3.903   15.441  1.000 17.060 0 694 HOH A O     1 ? 
HETATM 2869 O O     . HOH D 3 .   ? -3.722  -11.739 -27.141 1.000 32.892 0 695 HOH A O     1 ? 
HETATM 2870 O O     . HOH D 3 .   ? -16.222 -6.154  -6.636  1.000 29.055 0 696 HOH A O     1 ? 
HETATM 2871 O O     . HOH D 3 .   ? -5.790  12.940  9.755   1.000 14.735 0 697 HOH A O     1 ? 
HETATM 2872 O O     . HOH D 3 .   ? -11.412 8.347   4.307   1.000 17.018 0 698 HOH A O     1 ? 
HETATM 2873 O O     . HOH D 3 .   ? 19.507  -7.050  9.885   1.000 21.283 0 699 HOH A O     1 ? 
HETATM 2874 O O     . HOH D 3 .   ? -16.355 -18.345 -17.563 1.000 30.168 0 700 HOH A O     1 ? 
HETATM 2875 O O     . HOH D 3 .   ? -0.306  -2.939  22.575  1.000 36.592 0 701 HOH A O     1 ? 
HETATM 2876 O O     . HOH D 3 .   ? -8.905  8.898   28.740  1.000 41.847 0 702 HOH A O     1 ? 
HETATM 2877 O O     . HOH D 3 .   ? 18.543  10.939  17.526  1.000 31.313 0 703 HOH A O     1 ? 
HETATM 2878 O O     . HOH D 3 .   ? 11.570  25.645  16.213  1.000 34.634 0 704 HOH A O     1 ? 
HETATM 2879 O O     . HOH D 3 .   ? -1.694  15.126  -7.061  1.000 42.069 0 705 HOH A O     1 ? 
HETATM 2880 O O     . HOH D 3 .   ? -8.228  16.047  13.103  1.000 41.007 0 706 HOH A O     1 ? 
HETATM 2881 O O     . HOH D 3 .   ? -1.650  -2.863  20.670  1.000 29.064 0 707 HOH A O     1 ? 
HETATM 2882 O O     . HOH D 3 .   ? 18.063  1.015   17.870  1.000 16.648 0 708 HOH A O     1 ? 
HETATM 2883 O O     . HOH D 3 .   ? -19.214 -18.384 -22.158 1.000 45.276 0 709 HOH A O     1 ? 
HETATM 2884 O O     . HOH D 3 .   ? -4.989  15.060  8.844   1.000 19.345 0 710 HOH A O     1 ? 
HETATM 2885 O O     . HOH D 3 .   ? 7.696   -16.413 -3.257  1.000 52.054 0 711 HOH A O     1 ? 
HETATM 2886 O O     . HOH D 3 .   ? 10.441  -14.918 17.066  1.000 31.745 0 712 HOH A O     1 ? 
HETATM 2887 O O     . HOH D 3 .   ? -14.429 6.706   8.619   1.000 32.947 0 713 HOH A O     1 ? 
HETATM 2888 O O     . HOH D 3 .   ? -8.014  14.183  15.369  1.000 18.286 0 714 HOH A O     1 ? 
HETATM 2889 O O     . HOH D 3 .   ? -13.758 -7.821  11.153  1.000 39.230 0 715 HOH A O     1 ? 
HETATM 2890 O O     . HOH D 3 .   ? 7.469   14.232  -5.376  1.000 45.924 0 716 HOH A O     1 ? 
HETATM 2891 O O     . HOH D 3 .   ? -12.841 5.176   -4.221  1.000 45.066 0 717 HOH A O     1 ? 
HETATM 2892 O O     . HOH D 3 .   ? 16.647  4.596   19.505  1.000 24.967 0 718 HOH A O     1 ? 
HETATM 2893 O O     . HOH D 3 .   ? 10.738  1.554   -0.734  1.000 34.310 0 719 HOH A O     1 ? 
HETATM 2894 O O     . HOH D 3 .   ? -5.359  13.474  2.274   1.000 36.011 0 720 HOH A O     1 ? 
HETATM 2895 O O     . HOH D 3 .   ? -2.665  16.847  0.358   1.000 46.826 0 721 HOH A O     1 ? 
HETATM 2896 O O     . HOH D 3 .   ? 9.671   15.977  24.391  1.000 30.892 0 722 HOH A O     1 ? 
HETATM 2897 O O     . HOH D 3 .   ? -12.395 -5.109  11.088  1.000 21.495 0 723 HOH A O     1 ? 
HETATM 2898 O O     . HOH D 3 .   ? 20.948  10.982  17.093  1.000 34.787 0 724 HOH A O     1 ? 
HETATM 2899 O O     . HOH D 3 .   ? 19.805  13.955  20.330  1.000 27.694 0 725 HOH A O     1 ? 
HETATM 2900 O O     . HOH D 3 .   ? 1.931   21.698  5.805   1.000 30.693 0 726 HOH A O     1 ? 
HETATM 2901 O O     . HOH D 3 .   ? -5.077  15.603  17.990  1.000 16.126 0 727 HOH A O     1 ? 
HETATM 2902 O O     . HOH D 3 .   ? 3.359   -10.168 -3.280  1.000 39.318 0 728 HOH A O     1 ? 
HETATM 2903 O O     . HOH D 3 .   ? -7.452  -12.005 -33.091 1.000 31.347 0 729 HOH A O     1 ? 
HETATM 2904 O O     . HOH D 3 .   ? 23.627  -19.001 3.588   1.000 36.692 0 730 HOH A O     1 ? 
HETATM 2905 O O     . HOH D 3 .   ? 19.191  1.184   20.796  1.000 46.125 0 731 HOH A O     1 ? 
HETATM 2906 O O     . HOH D 3 .   ? 16.446  6.879   18.946  1.000 23.306 0 732 HOH A O     1 ? 
HETATM 2907 O O     . HOH D 3 .   ? -1.649  11.940  26.206  1.000 37.488 0 733 HOH A O     1 ? 
HETATM 2908 O O     . HOH D 3 .   ? -11.763 5.707   4.214   1.000 29.733 0 734 HOH A O     1 ? 
HETATM 2909 O O     . HOH D 3 .   ? 17.608  -11.358 -2.861  1.000 34.828 0 735 HOH A O     1 ? 
HETATM 2910 O O     . HOH D 3 .   ? -0.104  -17.615 4.163   1.000 38.567 0 736 HOH A O     1 ? 
HETATM 2911 O O     . HOH D 3 .   ? -3.082  -9.416  18.059  1.000 35.935 0 737 HOH A O     1 ? 
HETATM 2912 O O     . HOH D 3 .   ? -14.282 -11.093 -26.582 1.000 37.515 0 738 HOH A O     1 ? 
HETATM 2913 O O     . HOH D 3 .   ? 1.605   -22.921 -15.427 1.000 52.362 0 739 HOH A O     1 ? 
HETATM 2914 O O     . HOH D 3 .   ? -6.244  13.332  4.283   1.000 38.063 0 740 HOH A O     1 ? 
HETATM 2915 O O     . HOH D 3 .   ? -13.630 5.315   -11.945 1.000 42.576 0 741 HOH A O     1 ? 
HETATM 2916 O O     . HOH D 3 .   ? -2.638  -12.047 11.010  1.000 31.969 0 742 HOH A O     1 ? 
HETATM 2917 O O     . HOH D 3 .   ? -10.983 1.616   18.800  1.000 28.146 0 743 HOH A O     1 ? 
HETATM 2918 O O     . HOH D 3 .   ? 19.100  -13.722 0.019   1.000 39.812 0 744 HOH A O     1 ? 
HETATM 2919 O O     . HOH D 3 .   ? 21.524  5.380   2.344   1.000 30.967 0 745 HOH A O     1 ? 
HETATM 2920 O O     . HOH D 3 .   ? -19.427 -11.405 -37.225 1.000 40.289 0 746 HOH A O     1 ? 
HETATM 2921 O O     . HOH D 3 .   ? 19.334  6.409   22.780  1.000 37.786 0 747 HOH A O     1 ? 
HETATM 2922 O O     . HOH D 3 .   ? -11.962 16.192  10.211  1.000 36.127 0 748 HOH A O     1 ? 
HETATM 2923 O O     . HOH D 3 .   ? -9.486  -14.332 7.355   1.000 28.461 0 749 HOH A O     1 ? 
HETATM 2924 O O     . HOH D 3 .   ? -3.844  -19.875 -25.021 1.000 43.409 0 750 HOH A O     1 ? 
HETATM 2925 O O     . HOH D 3 .   ? 9.353   6.337   28.842  1.000 28.511 0 751 HOH A O     1 ? 
HETATM 2926 O O     . HOH D 3 .   ? 16.550  -11.359 13.738  1.000 23.105 0 752 HOH A O     1 ? 
HETATM 2927 O O     . HOH D 3 .   ? -1.978  19.503  15.889  1.000 25.679 0 753 HOH A O     1 ? 
HETATM 2928 O O     . HOH D 3 .   ? -2.407  21.377  -7.842  1.000 52.479 0 754 HOH A O     1 ? 
# 
