data_8YSG
# 
_entry.id   8YSG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YSG         pdb_00008ysg 10.2210/pdb8ysg/pdb 
WWPDB D_1300046293 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YSG 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chyeah6599@nchu.edu.tw 
_pdbx_contact_author.name_first         Yeh 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7740-0446 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, Y.-C.' 1 ? 
'Yang, C.-S.' 2 ? 
'Hou, M.-H.'  3 ? 
'Chen, Y.'    4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            295 
_citation.language                  ? 
_citation.page_first                139534 
_citation.page_last                 139534 
_citation.title                     
'Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.139534 
_citation.pdbx_database_id_PubMed   39761885 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, C.S.'  1 ? 
primary 'Shie, M.Y.'  2 ? 
primary 'Huang, S.W.' 3 ? 
primary 'Wang, Y.C.'  4 ? 
primary 'Hou, M.H.'   5 ? 
primary 'Chen, C.J.'  6 ? 
primary 'Chen, Y.'    7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleotidyltransferase      39217.918 1   ? ? ? ? 
2 non-polymer syn "GUANOSINE-5'-TRIPHOSPHATE" 523.180   2   ? ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'             24.305    2   ? ? ? ? 
4 water       nat water                       18.015    111 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "GUANOSINE-5'-TRIPHOSPHATE" GTP 
3 'MAGNESIUM ION'             MG  
4 water                       HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PRO n 
1 4   VAL n 
1 5   GLN n 
1 6   LYS n 
1 7   GLN n 
1 8   PHE n 
1 9   ARG n 
1 10  GLU n 
1 11  PHE n 
1 12  HIS n 
1 13  ASP n 
1 14  ARG n 
1 15  ILE n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLN n 
1 20  TYR n 
1 21  ASP n 
1 22  GLU n 
1 23  ASN n 
1 24  GLN n 
1 25  THR n 
1 26  LEU n 
1 27  ARG n 
1 28  ASP n 
1 29  GLU n 
1 30  ARG n 
1 31  ASP n 
1 32  ALA n 
1 33  VAL n 
1 34  LEU n 
1 35  THR n 
1 36  ALA n 
1 37  VAL n 
1 38  ARG n 
1 39  GLU n 
1 40  GLY n 
1 41  LEU n 
1 42  LYS n 
1 43  LYS n 
1 44  VAL n 
1 45  PHE n 
1 46  ALA n 
1 47  ASP n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  ALA n 
1 52  ALA n 
1 53  PRO n 
1 54  THR n 
1 55  PHE n 
1 56  THR n 
1 57  PRO n 
1 58  PHE n 
1 59  ASN n 
1 60  GLN n 
1 61  GLY n 
1 62  SER n 
1 63  TYR n 
1 64  ALA n 
1 65  MET n 
1 66  ASN n 
1 67  THR n 
1 68  GLY n 
1 69  VAL n 
1 70  LYS n 
1 71  PRO n 
1 72  LEU n 
1 73  GLU n 
1 74  GLY n 
1 75  GLY n 
1 76  GLU n 
1 77  TYR n 
1 78  ASP n 
1 79  ILE n 
1 80  ASP n 
1 81  VAL n 
1 82  GLY n 
1 83  ILE n 
1 84  ILE n 
1 85  LEU n 
1 86  ASN n 
1 87  ILE n 
1 88  ALA n 
1 89  LYS n 
1 90  ASP n 
1 91  ASP n 
1 92  HIS n 
1 93  ASP n 
1 94  PRO n 
1 95  VAL n 
1 96  GLU n 
1 97  VAL n 
1 98  LYS n 
1 99  LYS n 
1 100 TRP n 
1 101 ILE n 
1 102 ARG n 
1 103 ASP n 
1 104 ALA n 
1 105 LEU n 
1 106 LYS n 
1 107 ASP n 
1 108 TYR n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 ALA n 
1 113 GLU n 
1 114 ILE n 
1 115 ARG n 
1 116 ARG n 
1 117 SER n 
1 118 CYS n 
1 119 VAL n 
1 120 THR n 
1 121 VAL n 
1 122 PHE n 
1 123 LYS n 
1 124 PRO n 
1 125 GLY n 
1 126 TYR n 
1 127 HIS n 
1 128 VAL n 
1 129 ASP n 
1 130 LEU n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 ALA n 
1 135 ASP n 
1 136 PRO n 
1 137 GLU n 
1 138 LEU n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 LEU n 
1 144 CYS n 
1 145 ILE n 
1 146 ALA n 
1 147 LYS n 
1 148 GLY n 
1 149 LYS n 
1 150 GLU n 
1 151 ASN n 
1 152 SER n 
1 153 GLY n 
1 154 ASP n 
1 155 GLU n 
1 156 HIS n 
1 157 ARG n 
1 158 LEU n 
1 159 TRP n 
1 160 GLN n 
1 161 ILE n 
1 162 SER n 
1 163 ASP n 
1 164 PRO n 
1 165 GLN n 
1 166 GLY n 
1 167 PHE n 
1 168 GLN n 
1 169 ASP n 
1 170 ARG n 
1 171 ILE n 
1 172 ALA n 
1 173 SER n 
1 174 LYS n 
1 175 LEU n 
1 176 SER n 
1 177 GLY n 
1 178 ASP n 
1 179 ASP n 
1 180 ALA n 
1 181 ALA n 
1 182 GLN n 
1 183 PHE n 
1 184 ARG n 
1 185 ARG n 
1 186 CYS n 
1 187 ILE n 
1 188 ARG n 
1 189 TYR n 
1 190 LEU n 
1 191 LYS n 
1 192 ARG n 
1 193 TRP n 
1 194 ARG n 
1 195 ASP n 
1 196 PHE n 
1 197 ARG n 
1 198 PHE n 
1 199 SER n 
1 200 SER n 
1 201 ASP n 
1 202 GLY n 
1 203 ASN n 
1 204 ALA n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 LEU n 
1 212 THR n 
1 213 ALA n 
1 214 ALA n 
1 215 ALA n 
1 216 TYR n 
1 217 TRP n 
1 218 TRP n 
1 219 PHE n 
1 220 GLN n 
1 221 VAL n 
1 222 SER n 
1 223 LYS n 
1 224 ARG n 
1 225 THR n 
1 226 ASP n 
1 227 PRO n 
1 228 VAL n 
1 229 SER n 
1 230 GLN n 
1 231 ASN n 
1 232 VAL n 
1 233 THR n 
1 234 TYR n 
1 235 ASP n 
1 236 ASP n 
1 237 ARG n 
1 238 ASP n 
1 239 ALA n 
1 240 LEU n 
1 241 GLU n 
1 242 GLN n 
1 243 PHE n 
1 244 VAL n 
1 245 GLN n 
1 246 THR n 
1 247 MET n 
1 248 LEU n 
1 249 ASP n 
1 250 ASN n 
1 251 PHE n 
1 252 HIS n 
1 253 ASP n 
1 254 THR n 
1 255 TRP n 
1 256 ASP n 
1 257 SER n 
1 258 LYS n 
1 259 ASP n 
1 260 GLN n 
1 261 ARG n 
1 262 SER n 
1 263 TYR n 
1 264 PRO n 
1 265 ARG n 
1 266 LEU n 
1 267 THR n 
1 268 VAL n 
1 269 GLU n 
1 270 LEU n 
1 271 PRO n 
1 272 VAL n 
1 273 GLN n 
1 274 PRO n 
1 275 TYR n 
1 276 ASN n 
1 277 ASP n 
1 278 VAL n 
1 279 PHE n 
1 280 GLU n 
1 281 LYS n 
1 282 MET n 
1 283 THR n 
1 284 GLY n 
1 285 MET n 
1 286 GLN n 
1 287 MET n 
1 288 GLU n 
1 289 SER n 
1 290 PHE n 
1 291 LYS n 
1 292 SER n 
1 293 LYS n 
1 294 LEU n 
1 295 GLN n 
1 296 ALA n 
1 297 LEU n 
1 298 LEU n 
1 299 ASN n 
1 300 ALA n 
1 301 LEU n 
1 302 LYS n 
1 303 THR n 
1 304 ALA n 
1 305 LYS n 
1 306 SER n 
1 307 ARG n 
1 308 LEU n 
1 309 GLU n 
1 310 LEU n 
1 311 HIS n 
1 312 ASP n 
1 313 ALA n 
1 314 CYS n 
1 315 LYS n 
1 316 ALA n 
1 317 LEU n 
1 318 ALA n 
1 319 ASP n 
1 320 HIS n 
1 321 PHE n 
1 322 GLY n 
1 323 SER n 
1 324 GLU n 
1 325 PHE n 
1 326 PRO n 
1 327 VAL n 
1 328 PRO n 
1 329 GLU n 
1 330 LYS n 
1 331 ASP n 
1 332 LYS n 
1 333 SER n 
1 334 ALA n 
1 335 VAL n 
1 336 HIS n 
1 337 THR n 
1 338 ALA n 
1 339 PRO n 
1 340 ALA n 
1 341 ILE n 
1 342 VAL n 
1 343 GLY n 
1 344 SER n 
1 345 GLY n 
1 346 SER n 
1 347 SER n 
1 348 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   348 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 DVJ83_15700 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Deinococcus wulumuqiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     980427 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                     ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                    ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                  ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'             ? 'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                    ? 'C3 H7 N O2 S'      121.158 
GLN 'L-peptide linking' y GLUTAMINE                   ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'             ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                     ? 'C2 H5 N O2'        75.067  
GTP non-polymer         n "GUANOSINE-5'-TRIPHOSPHATE" ? 'C10 H16 N5 O14 P3' 523.180 
HIS 'L-peptide linking' y HISTIDINE                   ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                       ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                  ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                     ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                      ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                  ? 'C5 H11 N O2 S'     149.211 
MG  non-polymer         . 'MAGNESIUM ION'             ? 'Mg 2'              24.305  
PHE 'L-peptide linking' y PHENYLALANINE               ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                     ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                      ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                   ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                  ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                    ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                      ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   PRO 3   3   ?   ?   ?   A . n 
A 1 4   VAL 4   4   4   VAL VAL A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ALA 18  18  18  ALA ALA A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ASN 23  23  23  ASN ASN A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ASP 28  28  28  ASP ASP A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  ARG 30  30  30  ARG ARG A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  VAL 33  33  33  VAL VAL A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  THR 35  35  35  THR THR A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  PRO 53  53  53  PRO PRO A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  TYR 63  63  63  TYR TYR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  MET 65  65  65  MET MET A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  GLY 68  68  68  GLY GLY A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 CYS 118 118 118 CYS CYS A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LYS 123 123 123 LYS LYS A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 HIS 127 127 127 HIS HIS A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 GLY 141 141 141 GLY GLY A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 ASP 154 154 154 ASP ASP A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 HIS 156 156 156 HIS HIS A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 PRO 164 164 164 PRO PRO A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLN 168 168 168 GLN GLN A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ASP 178 178 178 ASP ASP A . n 
A 1 179 ASP 179 179 179 ASP ASP A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 CYS 186 186 186 CYS CYS A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 SER 199 199 ?   ?   ?   A . n 
A 1 200 SER 200 200 ?   ?   ?   A . n 
A 1 201 ASP 201 201 ?   ?   ?   A . n 
A 1 202 GLY 202 202 ?   ?   ?   A . n 
A 1 203 ASN 203 203 ?   ?   ?   A . n 
A 1 204 ALA 204 204 ?   ?   ?   A . n 
A 1 205 ALA 205 205 ?   ?   ?   A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 LEU 211 211 211 LEU LEU A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 VAL 221 221 221 VAL VAL A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 GLN 230 230 230 GLN GLN A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 TYR 234 234 234 TYR TYR A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 ARG 237 237 237 ARG ARG A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 PHE 243 243 243 PHE PHE A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 MET 247 247 247 MET MET A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 ASP 249 249 249 ASP ASP A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 HIS 252 252 252 HIS HIS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 TRP 255 255 255 TRP TRP A . n 
A 1 256 ASP 256 256 256 ASP ASP A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 PRO 264 264 264 PRO PRO A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 GLU 269 269 269 GLU GLU A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 ASP 277 277 277 ASP ASP A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 LYS 281 281 281 LYS LYS A . n 
A 1 282 MET 282 282 282 MET MET A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 SER 289 289 289 SER SER A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 GLN 295 295 295 GLN GLN A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 LEU 297 297 297 LEU LEU A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 SER 306 306 306 SER SER A . n 
A 1 307 ARG 307 307 307 ARG ARG A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 GLU 309 309 309 GLU GLU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 HIS 311 311 311 HIS HIS A . n 
A 1 312 ASP 312 312 312 ASP ASP A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 ALA 318 318 318 ALA ALA A . n 
A 1 319 ASP 319 319 319 ASP ASP A . n 
A 1 320 HIS 320 320 320 HIS HIS A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 GLU 324 324 324 GLU GLU A . n 
A 1 325 PHE 325 325 325 PHE PHE A . n 
A 1 326 PRO 326 326 326 PRO PRO A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 PRO 328 328 328 PRO PRO A . n 
A 1 329 GLU 329 329 329 GLU GLU A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 ASP 331 331 ?   ?   ?   A . n 
A 1 332 LYS 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 ALA 334 334 ?   ?   ?   A . n 
A 1 335 VAL 335 335 ?   ?   ?   A . n 
A 1 336 HIS 336 336 ?   ?   ?   A . n 
A 1 337 THR 337 337 ?   ?   ?   A . n 
A 1 338 ALA 338 338 ?   ?   ?   A . n 
A 1 339 PRO 339 339 ?   ?   ?   A . n 
A 1 340 ALA 340 340 ?   ?   ?   A . n 
A 1 341 ILE 341 341 ?   ?   ?   A . n 
A 1 342 VAL 342 342 ?   ?   ?   A . n 
A 1 343 GLY 343 343 ?   ?   ?   A . n 
A 1 344 SER 344 344 ?   ?   ?   A . n 
A 1 345 GLY 345 345 ?   ?   ?   A . n 
A 1 346 SER 346 346 ?   ?   ?   A . n 
A 1 347 SER 347 347 ?   ?   ?   A . n 
A 1 348 GLY 348 348 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        GTP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   GTP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 GTP 1   401 360 GTP GTP A . 
C 2 GTP 1   402 361 GTP GTP A . 
D 3 MG  1   403 380 MG  MG  A . 
E 3 MG  1   404 381 MG  MG  A . 
F 4 HOH 1   501 441 HOH HOH A . 
F 4 HOH 2   502 449 HOH HOH A . 
F 4 HOH 3   503 500 HOH HOH A . 
F 4 HOH 4   504 403 HOH HOH A . 
F 4 HOH 5   505 506 HOH HOH A . 
F 4 HOH 6   506 413 HOH HOH A . 
F 4 HOH 7   507 482 HOH HOH A . 
F 4 HOH 8   508 425 HOH HOH A . 
F 4 HOH 9   509 444 HOH HOH A . 
F 4 HOH 10  510 400 HOH HOH A . 
F 4 HOH 11  511 499 HOH HOH A . 
F 4 HOH 12  512 467 HOH HOH A . 
F 4 HOH 13  513 428 HOH HOH A . 
F 4 HOH 14  514 510 HOH HOH A . 
F 4 HOH 15  515 420 HOH HOH A . 
F 4 HOH 16  516 501 HOH HOH A . 
F 4 HOH 17  517 445 HOH HOH A . 
F 4 HOH 18  518 494 HOH HOH A . 
F 4 HOH 19  519 419 HOH HOH A . 
F 4 HOH 20  520 405 HOH HOH A . 
F 4 HOH 21  521 414 HOH HOH A . 
F 4 HOH 22  522 447 HOH HOH A . 
F 4 HOH 23  523 440 HOH HOH A . 
F 4 HOH 24  524 463 HOH HOH A . 
F 4 HOH 25  525 442 HOH HOH A . 
F 4 HOH 26  526 483 HOH HOH A . 
F 4 HOH 27  527 408 HOH HOH A . 
F 4 HOH 28  528 429 HOH HOH A . 
F 4 HOH 29  529 422 HOH HOH A . 
F 4 HOH 30  530 416 HOH HOH A . 
F 4 HOH 31  531 439 HOH HOH A . 
F 4 HOH 32  532 460 HOH HOH A . 
F 4 HOH 33  533 410 HOH HOH A . 
F 4 HOH 34  534 404 HOH HOH A . 
F 4 HOH 35  535 437 HOH HOH A . 
F 4 HOH 36  536 451 HOH HOH A . 
F 4 HOH 37  537 435 HOH HOH A . 
F 4 HOH 38  538 450 HOH HOH A . 
F 4 HOH 39  539 479 HOH HOH A . 
F 4 HOH 40  540 457 HOH HOH A . 
F 4 HOH 41  541 433 HOH HOH A . 
F 4 HOH 42  542 423 HOH HOH A . 
F 4 HOH 43  543 407 HOH HOH A . 
F 4 HOH 44  544 491 HOH HOH A . 
F 4 HOH 45  545 459 HOH HOH A . 
F 4 HOH 46  546 503 HOH HOH A . 
F 4 HOH 47  547 432 HOH HOH A . 
F 4 HOH 48  548 495 HOH HOH A . 
F 4 HOH 49  549 402 HOH HOH A . 
F 4 HOH 50  550 421 HOH HOH A . 
F 4 HOH 51  551 412 HOH HOH A . 
F 4 HOH 52  552 417 HOH HOH A . 
F 4 HOH 53  553 446 HOH HOH A . 
F 4 HOH 54  554 448 HOH HOH A . 
F 4 HOH 55  555 431 HOH HOH A . 
F 4 HOH 56  556 456 HOH HOH A . 
F 4 HOH 57  557 474 HOH HOH A . 
F 4 HOH 58  558 438 HOH HOH A . 
F 4 HOH 59  559 461 HOH HOH A . 
F 4 HOH 60  560 462 HOH HOH A . 
F 4 HOH 61  561 458 HOH HOH A . 
F 4 HOH 62  562 443 HOH HOH A . 
F 4 HOH 63  563 415 HOH HOH A . 
F 4 HOH 64  564 426 HOH HOH A . 
F 4 HOH 65  565 454 HOH HOH A . 
F 4 HOH 66  566 427 HOH HOH A . 
F 4 HOH 67  567 453 HOH HOH A . 
F 4 HOH 68  568 473 HOH HOH A . 
F 4 HOH 69  569 434 HOH HOH A . 
F 4 HOH 70  570 418 HOH HOH A . 
F 4 HOH 71  571 411 HOH HOH A . 
F 4 HOH 72  572 406 HOH HOH A . 
F 4 HOH 73  573 493 HOH HOH A . 
F 4 HOH 74  574 401 HOH HOH A . 
F 4 HOH 75  575 504 HOH HOH A . 
F 4 HOH 76  576 455 HOH HOH A . 
F 4 HOH 77  577 488 HOH HOH A . 
F 4 HOH 78  578 464 HOH HOH A . 
F 4 HOH 79  579 409 HOH HOH A . 
F 4 HOH 80  580 452 HOH HOH A . 
F 4 HOH 81  581 485 HOH HOH A . 
F 4 HOH 82  582 487 HOH HOH A . 
F 4 HOH 83  583 436 HOH HOH A . 
F 4 HOH 84  584 424 HOH HOH A . 
F 4 HOH 85  585 492 HOH HOH A . 
F 4 HOH 86  586 465 HOH HOH A . 
F 4 HOH 87  587 509 HOH HOH A . 
F 4 HOH 88  588 475 HOH HOH A . 
F 4 HOH 89  589 430 HOH HOH A . 
F 4 HOH 90  590 472 HOH HOH A . 
F 4 HOH 91  591 470 HOH HOH A . 
F 4 HOH 92  592 490 HOH HOH A . 
F 4 HOH 93  593 478 HOH HOH A . 
F 4 HOH 94  594 486 HOH HOH A . 
F 4 HOH 95  595 505 HOH HOH A . 
F 4 HOH 96  596 466 HOH HOH A . 
F 4 HOH 97  597 480 HOH HOH A . 
F 4 HOH 98  598 468 HOH HOH A . 
F 4 HOH 99  599 481 HOH HOH A . 
F 4 HOH 100 600 498 HOH HOH A . 
F 4 HOH 101 601 476 HOH HOH A . 
F 4 HOH 102 602 502 HOH HOH A . 
F 4 HOH 103 603 477 HOH HOH A . 
F 4 HOH 104 604 496 HOH HOH A . 
F 4 HOH 105 605 469 HOH HOH A . 
F 4 HOH 106 606 471 HOH HOH A . 
F 4 HOH 107 607 489 HOH HOH A . 
F 4 HOH 108 608 507 HOH HOH A . 
F 4 HOH 109 609 484 HOH HOH A . 
F 4 HOH 110 610 497 HOH HOH A . 
F 4 HOH 111 611 508 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0258 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? Blu-Ice  ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.621 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YSG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.033 
_cell.length_a_esd                 ? 
_cell.length_b                     100.404 
_cell.length_b_esd                 ? 
_cell.length_c                     46.398 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YSG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YSG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.04 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.65 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M sodium formate, 20 % w/v PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-05-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.99984 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 05A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.99984 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 05A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YSG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.17 
_reflns.d_resolution_low                               30 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     16522 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          47.211 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.028 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.17 
_reflns_shell.d_res_low                                     2.25 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1572 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.979 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.014 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            -0.022 
_refine.aniso_B[2][2]                            -0.079 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            0.093 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               37.635 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.919 
_refine.correlation_coeff_Fo_to_Fc_free          0.900 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YSG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.171 
_refine.ls_d_res_low                             22.734 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     16498 
_refine.ls_number_reflns_R_free                  824 
_refine.ls_number_reflns_R_work                  15674 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.356 
_refine.ls_percent_reflns_R_free                 4.995 
_refine.ls_R_factor_all                          0.243 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2718 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2417 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.413 
_refine.pdbx_overall_ESU_R_Free                  0.253 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             8.834 
_refine.overall_SU_ML                            0.217 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2585 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         66 
_refine_hist.number_atoms_solvent             111 
_refine_hist.number_atoms_total               2762 
_refine_hist.d_res_high                       2.171 
_refine_hist.d_res_low                        22.734 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.013  2712 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  2424 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.393  1.654  3678 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.244  1.590  5628 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 8.126  5.000  318  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 35.299 22.037 162  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 17.559 15.000 457  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 18.475 15.000 22   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.060  0.200  339  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.008  0.020  3024 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  598  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.220  0.200  649  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.203  0.200  2453 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.170  0.200  1262 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.077  0.200  1242 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.207  0.200  120  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.168  0.200  3    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.223  0.200  18   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.237  0.200  38   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.214  0.200  6    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.349  3.904  1278 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.341  3.903  1277 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.250  5.848  1594 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.249  5.849  1595 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 2.964  4.207  1434 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.960  4.204  1432 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.702  6.227  2084 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.701  6.231  2085 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 8.982  45.061 3134 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.982  45.045 3127 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.171 2.227  . . 49 1108 97.0638  . . . . 0.320 . . . . . . . . . . . 0.351 
'X-RAY DIFFRACTION' 2.227 2.288  . . 62 1132 100.0000 . . . . 0.318 . . . . . . . . . . . 0.350 
'X-RAY DIFFRACTION' 2.288 2.354  . . 71 1107 100.0000 . . . . 0.314 . . . . . . . . . . . 0.463 
'X-RAY DIFFRACTION' 2.354 2.426  . . 42 1058 100.0000 . . . . 0.307 . . . . . . . . . . . 0.337 
'X-RAY DIFFRACTION' 2.426 2.505  . . 59 1039 100.0000 . . . . 0.305 . . . . . . . . . . . 0.343 
'X-RAY DIFFRACTION' 2.505 2.592  . . 53 988  100.0000 . . . . 0.312 . . . . . . . . . . . 0.315 
'X-RAY DIFFRACTION' 2.592 2.689  . . 48 984  100.0000 . . . . 0.292 . . . . . . . . . . . 0.310 
'X-RAY DIFFRACTION' 2.689 2.798  . . 52 916  100.0000 . . . . 0.264 . . . . . . . . . . . 0.282 
'X-RAY DIFFRACTION' 2.798 2.921  . . 39 921  100.0000 . . . . 0.263 . . . . . . . . . . . 0.272 
'X-RAY DIFFRACTION' 2.921 3.063  . . 49 831  99.8865  . . . . 0.255 . . . . . . . . . . . 0.286 
'X-RAY DIFFRACTION' 3.063 3.226  . . 40 824  99.8844  . . . . 0.261 . . . . . . . . . . . 0.371 
'X-RAY DIFFRACTION' 3.226 3.420  . . 41 763  100.0000 . . . . 0.248 . . . . . . . . . . . 0.228 
'X-RAY DIFFRACTION' 3.420 3.652  . . 37 720  100.0000 . . . . 0.235 . . . . . . . . . . . 0.272 
'X-RAY DIFFRACTION' 3.652 3.940  . . 44 682  100.0000 . . . . 0.214 . . . . . . . . . . . 0.228 
'X-RAY DIFFRACTION' 3.940 4.309  . . 29 624  100.0000 . . . . 0.189 . . . . . . . . . . . 0.191 
'X-RAY DIFFRACTION' 4.309 4.805  . . 28 565  100.0000 . . . . 0.166 . . . . . . . . . . . 0.172 
'X-RAY DIFFRACTION' 4.805 5.525  . . 29 492  100.0000 . . . . 0.181 . . . . . . . . . . . 0.253 
'X-RAY DIFFRACTION' 5.525 6.710  . . 21 437  99.7821  . . . . 0.194 . . . . . . . . . . . 0.262 
'X-RAY DIFFRACTION' 6.710 9.260  . . 20 333  98.3287  . . . . 0.176 . . . . . . . . . . . 0.181 
'X-RAY DIFFRACTION' 9.260 22.734 . . 11 150  74.1936  . . . . 0.201 . . . . . . . . . . . 0.225 
# 
_struct.entry_id                     8YSG 
_struct.title                        'Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with GTP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YSG 
_struct_keywords.text            'CD-NTase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A345ILN6_9DEIO 
_struct_ref.pdbx_db_accession          A0A345ILN6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAPVQKQFREFHDRIKLAQYDENQTLRDERDAVLTAVREGLKKVFADRGEAAPTFTPFNQGSYAMNTGVKPLEGGEYDID
VGIILNIAKDDHDPVEVKKWIRDALKDYGNGAEIRRSCVTVFKPGYHVDLAVYADPELSGGTLCIAKGKENSGDEHRLWQ
ISDPQGFQDRIASKLSGDDAAQFRRCIRYLKRWRDFRFSSDGNAAPLGIGLTAAAYWWFQVSKRTDPVSQNVTYDDRDAL
EQFVQTMLDNFHDTWDSKDQRSYPRLTVELPVQPYNDVFEKMTGMQMESFKSKLQALLNALKTAKSRLELHDACKALADH
FGSEFPVPEKDKSAVHTAPAIVGSGSSG
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YSG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 348 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A345ILN6 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  348 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       348 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 4   ? LYS A 16  ? VAL A 4   LYS A 16  1 ? 13 
HELX_P HELX_P2  AA2 GLN A 19  ? GLU A 22  ? GLN A 19  GLU A 22  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 23  ? LYS A 43  ? ASN A 23  LYS A 43  1 ? 21 
HELX_P HELX_P4  AA4 GLN A 60  ? ASN A 66  ? GLN A 60  ASN A 66  1 ? 7  
HELX_P HELX_P5  AA5 ASP A 93  ? LYS A 106 ? ASP A 93  LYS A 106 1 ? 14 
HELX_P HELX_P6  AA6 ASP A 163 ? LYS A 174 ? ASP A 163 LYS A 174 1 ? 12 
HELX_P HELX_P7  AA7 SER A 176 ? PHE A 198 ? SER A 176 PHE A 198 1 ? 23 
HELX_P HELX_P8  AA8 LEU A 207 ? PHE A 219 ? LEU A 207 PHE A 219 1 ? 13 
HELX_P HELX_P9  AA9 ASP A 235 ? ASN A 250 ? ASP A 235 ASN A 250 1 ? 16 
HELX_P HELX_P10 AB1 ASP A 277 ? MET A 282 ? ASP A 277 MET A 282 5 ? 6  
HELX_P HELX_P11 AB2 THR A 283 ? ALA A 304 ? THR A 283 ALA A 304 1 ? 22 
HELX_P HELX_P12 AB3 GLU A 309 ? GLY A 322 ? GLU A 309 GLY A 322 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A ASP 78  OD2   ? ? ? 1_555 D MG  . MG ? ? A ASP 78  A MG  403 1_555 ? ? ? ? ? ? ? 2.320 ? ? 
metalc2  metalc ? ? A ASP 78  OD1   ? ? ? 1_555 E MG  . MG ? ? A ASP 78  A MG  404 1_555 ? ? ? ? ? ? ? 2.330 ? ? 
metalc3  metalc ? ? A ASP 78  OD2   ? ? ? 1_555 E MG  . MG ? ? A ASP 78  A MG  404 1_555 ? ? ? ? ? ? ? 2.583 ? ? 
metalc4  metalc ? ? A ASP 80  OD1   ? ? ? 1_555 D MG  . MG ? ? A ASP 80  A MG  403 1_555 ? ? ? ? ? ? ? 2.007 ? ? 
metalc5  metalc ? ? A ASP 80  OD2   ? ? ? 1_555 E MG  . MG ? ? A ASP 80  A MG  404 1_555 ? ? ? ? ? ? ? 2.634 ? ? 
metalc6  metalc ? ? A ASP 129 OD2   ? ? ? 1_555 E MG  . MG ? ? A ASP 129 A MG  404 1_555 ? ? ? ? ? ? ? 2.089 ? ? 
metalc7  metalc ? ? B GTP .   O2G   ? ? ? 1_555 D MG  . MG ? ? A GTP 401 A MG  403 1_555 ? ? ? ? ? ? ? 2.071 ? ? 
metalc8  metalc ? ? B GTP .   O2B   ? ? ? 1_555 D MG  . MG ? ? A GTP 401 A MG  403 1_555 ? ? ? ? ? ? ? 2.210 ? ? 
metalc9  metalc ? ? B GTP .   O1A   ? ? ? 1_555 D MG  . MG ? ? A GTP 401 A MG  403 1_555 ? ? ? ? ? ? ? 2.287 ? ? 
metalc10 metalc ? ? B GTP .   O1A   ? ? ? 1_555 E MG  . MG ? ? A GTP 401 A MG  404 1_555 ? ? ? ? ? ? ? 2.873 ? ? 
metalc11 metalc ? ? C GTP .   "O3'" ? ? ? 1_555 E MG  . MG ? ? A GTP 402 A MG  404 1_555 ? ? ? ? ? ? ? 2.285 ? ? 
metalc12 metalc ? ? C GTP .   "O2'" ? ? ? 1_555 E MG  . MG ? ? A GTP 402 A MG  404 1_555 ? ? ? ? ? ? ? 2.400 ? ? 
metalc13 metalc ? ? D MG  .   MG    ? ? ? 1_555 F HOH . O  ? ? A MG  403 A HOH 516 1_555 ? ? ? ? ? ? ? 2.128 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 OD1   ? A ASP 80  ? A ASP 80  ? 1_555 84.2  ? 
2  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2G   ? B GTP .   ? A GTP 401 ? 1_555 85.0  ? 
3  OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2G   ? B GTP .   ? A GTP 401 ? 1_555 168.2 ? 
4  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2B   ? B GTP .   ? A GTP 401 ? 1_555 170.6 ? 
5  OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2B   ? B GTP .   ? A GTP 401 ? 1_555 96.0  ? 
6  O2G   ? B GTP .   ? A GTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O2B   ? B GTP .   ? A GTP 401 ? 1_555 93.9  ? 
7  OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 77.1  ? 
8  OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 88.7  ? 
9  O2G   ? B GTP .   ? A GTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 84.4  ? 
10 O2B   ? B GTP .   ? A GTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 93.5  ? 
11 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 89.1  ? 
12 OD1   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 97.6  ? 
13 O2G   ? B GTP .   ? A GTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 86.8  ? 
14 O2B   ? B GTP .   ? A GTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 100.1 ? 
15 O1A   ? B GTP .   ? A GTP 401 ? 1_555 MG ? D MG . ? A MG 403 ? 1_555 O     ? F HOH .   ? A HOH 516 ? 1_555 164.2 ? 
16 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 52.8  ? 
17 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 88.2  ? 
18 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 69.8  ? 
19 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 80.3  ? 
20 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 129.0 ? 
21 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 92.4  ? 
22 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 114.4 ? 
23 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 63.2  ? 
24 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 82.8  ? 
25 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 O1A   ? B GTP .   ? A GTP 401 ? 1_555 164.3 ? 
26 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C GTP .   ? A GTP 402 ? 1_555 124.1 ? 
27 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C GTP .   ? A GTP 402 ? 1_555 129.1 ? 
28 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C GTP .   ? A GTP 402 ? 1_555 147.6 ? 
29 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C GTP .   ? A GTP 402 ? 1_555 91.5  ? 
30 O1A   ? B GTP .   ? A GTP 401 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O3'" ? C GTP .   ? A GTP 402 ? 1_555 84.9  ? 
31 OD1   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C GTP .   ? A GTP 402 ? 1_555 166.4 ? 
32 OD2   ? A ASP 78  ? A ASP 78  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C GTP .   ? A GTP 402 ? 1_555 122.7 ? 
33 OD2   ? A ASP 80  ? A ASP 80  ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C GTP .   ? A GTP 402 ? 1_555 78.4  ? 
34 OD2   ? A ASP 129 ? A ASP 129 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C GTP .   ? A GTP 402 ? 1_555 97.8  ? 
35 O1A   ? B GTP .   ? A GTP 401 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C GTP .   ? A GTP 402 ? 1_555 66.6  ? 
36 "O3'" ? C GTP .   ? A GTP 402 ? 1_555 MG ? E MG . ? A MG 404 ? 1_555 "O2'" ? C GTP .   ? A GTP 402 ? 1_555 69.3  ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           273 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            273 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    274 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     274 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.04 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? ASN A 59  ? PHE A 55  ASN A 59  
AA1 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA1 3 TYR A 126 ? ALA A 134 ? TYR A 126 ALA A 134 
AA1 4 CYS A 118 ? LYS A 123 ? CYS A 118 LYS A 123 
AA1 5 ALA A 112 ? ARG A 115 ? ALA A 112 ARG A 115 
AA2 1 PHE A 55  ? ASN A 59  ? PHE A 55  ASN A 59  
AA2 2 TYR A 77  ? LEU A 85  ? TYR A 77  LEU A 85  
AA2 3 TYR A 126 ? ALA A 134 ? TYR A 126 ALA A 134 
AA2 4 CYS A 144 ? LYS A 147 ? CYS A 144 LYS A 147 
AA2 5 LEU A 158 ? ILE A 161 ? LEU A 158 ILE A 161 
AA3 1 LYS A 223 ? THR A 225 ? LYS A 223 THR A 225 
AA3 2 VAL A 232 ? TYR A 234 ? VAL A 232 TYR A 234 
AA4 1 HIS A 252 ? ASP A 256 ? HIS A 252 ASP A 256 
AA4 2 ARG A 261 ? ARG A 265 ? ARG A 261 ARG A 265 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N THR A 56  ? N THR A 56  O ILE A 84  ? O ILE A 84  
AA1 2 3 N ILE A 83  ? N ILE A 83  O TYR A 133 ? O TYR A 133 
AA1 3 4 O LEU A 130 ? O LEU A 130 N VAL A 119 ? N VAL A 119 
AA1 4 5 O CYS A 118 ? O CYS A 118 N ARG A 115 ? N ARG A 115 
AA2 1 2 N THR A 56  ? N THR A 56  O ILE A 84  ? O ILE A 84  
AA2 2 3 N ILE A 83  ? N ILE A 83  O TYR A 133 ? O TYR A 133 
AA2 3 4 N ALA A 134 ? N ALA A 134 O CYS A 144 ? O CYS A 144 
AA2 4 5 N ILE A 145 ? N ILE A 145 O GLN A 160 ? O GLN A 160 
AA3 1 2 N ARG A 224 ? N ARG A 224 O THR A 233 ? O THR A 233 
AA4 1 2 N ASP A 256 ? N ASP A 256 O ARG A 261 ? O ARG A 261 
# 
_pdbx_entry_details.entry_id                   8YSG 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   NH1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ARG 
_pdbx_validate_close_contact.auth_seq_id_1    194 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O1G 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   GTP 
_pdbx_validate_close_contact.auth_seq_id_2    401 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 VAL A 44  ? ? -122.10 -57.05  
2  1 PHE A 45  ? ? -87.11  41.71   
3  1 PRO A 124 ? ? -59.06  104.96  
4  1 ASP A 163 ? ? -150.02 60.79   
5  1 LEU A 175 ? ? -129.41 -166.69 
6  1 LEU A 207 ? ? -19.89  128.47  
7  1 GLN A 260 ? ? 39.23   46.75   
8  1 SER A 306 ? ? -157.32 -62.19  
9  1 ARG A 307 ? ? -29.50  -64.39  
10 1 ALA A 313 ? ? -41.71  -80.97  
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       611 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.38 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A PRO 3   ? A PRO 3   
4  1 Y 1 A SER 199 ? A SER 199 
5  1 Y 1 A SER 200 ? A SER 200 
6  1 Y 1 A ASP 201 ? A ASP 201 
7  1 Y 1 A GLY 202 ? A GLY 202 
8  1 Y 1 A ASN 203 ? A ASN 203 
9  1 Y 1 A ALA 204 ? A ALA 204 
10 1 Y 1 A ALA 205 ? A ALA 205 
11 1 Y 1 A ASP 331 ? A ASP 331 
12 1 Y 1 A LYS 332 ? A LYS 332 
13 1 Y 1 A SER 333 ? A SER 333 
14 1 Y 1 A ALA 334 ? A ALA 334 
15 1 Y 1 A VAL 335 ? A VAL 335 
16 1 Y 1 A HIS 336 ? A HIS 336 
17 1 Y 1 A THR 337 ? A THR 337 
18 1 Y 1 A ALA 338 ? A ALA 338 
19 1 Y 1 A PRO 339 ? A PRO 339 
20 1 Y 1 A ALA 340 ? A ALA 340 
21 1 Y 1 A ILE 341 ? A ILE 341 
22 1 Y 1 A VAL 342 ? A VAL 342 
23 1 Y 1 A GLY 343 ? A GLY 343 
24 1 Y 1 A SER 344 ? A SER 344 
25 1 Y 1 A GLY 345 ? A GLY 345 
26 1 Y 1 A SER 346 ? A SER 346 
27 1 Y 1 A SER 347 ? A SER 347 
28 1 Y 1 A GLY 348 ? A GLY 348 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CYS N      N  N N 74  
CYS CA     C  N R 75  
CYS C      C  N N 76  
CYS O      O  N N 77  
CYS CB     C  N N 78  
CYS SG     S  N N 79  
CYS OXT    O  N N 80  
CYS H      H  N N 81  
CYS H2     H  N N 82  
CYS HA     H  N N 83  
CYS HB2    H  N N 84  
CYS HB3    H  N N 85  
CYS HG     H  N N 86  
CYS HXT    H  N N 87  
GLN N      N  N N 88  
GLN CA     C  N S 89  
GLN C      C  N N 90  
GLN O      O  N N 91  
GLN CB     C  N N 92  
GLN CG     C  N N 93  
GLN CD     C  N N 94  
GLN OE1    O  N N 95  
GLN NE2    N  N N 96  
GLN OXT    O  N N 97  
GLN H      H  N N 98  
GLN H2     H  N N 99  
GLN HA     H  N N 100 
GLN HB2    H  N N 101 
GLN HB3    H  N N 102 
GLN HG2    H  N N 103 
GLN HG3    H  N N 104 
GLN HE21   H  N N 105 
GLN HE22   H  N N 106 
GLN HXT    H  N N 107 
GLU N      N  N N 108 
GLU CA     C  N S 109 
GLU C      C  N N 110 
GLU O      O  N N 111 
GLU CB     C  N N 112 
GLU CG     C  N N 113 
GLU CD     C  N N 114 
GLU OE1    O  N N 115 
GLU OE2    O  N N 116 
GLU OXT    O  N N 117 
GLU H      H  N N 118 
GLU H2     H  N N 119 
GLU HA     H  N N 120 
GLU HB2    H  N N 121 
GLU HB3    H  N N 122 
GLU HG2    H  N N 123 
GLU HG3    H  N N 124 
GLU HE2    H  N N 125 
GLU HXT    H  N N 126 
GLY N      N  N N 127 
GLY CA     C  N N 128 
GLY C      C  N N 129 
GLY O      O  N N 130 
GLY OXT    O  N N 131 
GLY H      H  N N 132 
GLY H2     H  N N 133 
GLY HA2    H  N N 134 
GLY HA3    H  N N 135 
GLY HXT    H  N N 136 
GTP PG     P  N N 137 
GTP O1G    O  N N 138 
GTP O2G    O  N N 139 
GTP O3G    O  N N 140 
GTP O3B    O  N N 141 
GTP PB     P  N N 142 
GTP O1B    O  N N 143 
GTP O2B    O  N N 144 
GTP O3A    O  N N 145 
GTP PA     P  N N 146 
GTP O1A    O  N N 147 
GTP O2A    O  N N 148 
GTP "O5'"  O  N N 149 
GTP "C5'"  C  N N 150 
GTP "C4'"  C  N R 151 
GTP "O4'"  O  N N 152 
GTP "C3'"  C  N S 153 
GTP "O3'"  O  N N 154 
GTP "C2'"  C  N R 155 
GTP "O2'"  O  N N 156 
GTP "C1'"  C  N R 157 
GTP N9     N  Y N 158 
GTP C8     C  Y N 159 
GTP N7     N  Y N 160 
GTP C5     C  Y N 161 
GTP C6     C  N N 162 
GTP O6     O  N N 163 
GTP N1     N  N N 164 
GTP C2     C  N N 165 
GTP N2     N  N N 166 
GTP N3     N  N N 167 
GTP C4     C  Y N 168 
GTP HOG2   H  N N 169 
GTP HOG3   H  N N 170 
GTP HOB2   H  N N 171 
GTP HOA2   H  N N 172 
GTP "H5'"  H  N N 173 
GTP "H5''" H  N N 174 
GTP "H4'"  H  N N 175 
GTP "H3'"  H  N N 176 
GTP "HO3'" H  N N 177 
GTP "H2'"  H  N N 178 
GTP "HO2'" H  N N 179 
GTP "H1'"  H  N N 180 
GTP H8     H  N N 181 
GTP HN1    H  N N 182 
GTP HN21   H  N N 183 
GTP HN22   H  N N 184 
HIS N      N  N N 185 
HIS CA     C  N S 186 
HIS C      C  N N 187 
HIS O      O  N N 188 
HIS CB     C  N N 189 
HIS CG     C  Y N 190 
HIS ND1    N  Y N 191 
HIS CD2    C  Y N 192 
HIS CE1    C  Y N 193 
HIS NE2    N  Y N 194 
HIS OXT    O  N N 195 
HIS H      H  N N 196 
HIS H2     H  N N 197 
HIS HA     H  N N 198 
HIS HB2    H  N N 199 
HIS HB3    H  N N 200 
HIS HD1    H  N N 201 
HIS HD2    H  N N 202 
HIS HE1    H  N N 203 
HIS HE2    H  N N 204 
HIS HXT    H  N N 205 
HOH O      O  N N 206 
HOH H1     H  N N 207 
HOH H2     H  N N 208 
ILE N      N  N N 209 
ILE CA     C  N S 210 
ILE C      C  N N 211 
ILE O      O  N N 212 
ILE CB     C  N S 213 
ILE CG1    C  N N 214 
ILE CG2    C  N N 215 
ILE CD1    C  N N 216 
ILE OXT    O  N N 217 
ILE H      H  N N 218 
ILE H2     H  N N 219 
ILE HA     H  N N 220 
ILE HB     H  N N 221 
ILE HG12   H  N N 222 
ILE HG13   H  N N 223 
ILE HG21   H  N N 224 
ILE HG22   H  N N 225 
ILE HG23   H  N N 226 
ILE HD11   H  N N 227 
ILE HD12   H  N N 228 
ILE HD13   H  N N 229 
ILE HXT    H  N N 230 
LEU N      N  N N 231 
LEU CA     C  N S 232 
LEU C      C  N N 233 
LEU O      O  N N 234 
LEU CB     C  N N 235 
LEU CG     C  N N 236 
LEU CD1    C  N N 237 
LEU CD2    C  N N 238 
LEU OXT    O  N N 239 
LEU H      H  N N 240 
LEU H2     H  N N 241 
LEU HA     H  N N 242 
LEU HB2    H  N N 243 
LEU HB3    H  N N 244 
LEU HG     H  N N 245 
LEU HD11   H  N N 246 
LEU HD12   H  N N 247 
LEU HD13   H  N N 248 
LEU HD21   H  N N 249 
LEU HD22   H  N N 250 
LEU HD23   H  N N 251 
LEU HXT    H  N N 252 
LYS N      N  N N 253 
LYS CA     C  N S 254 
LYS C      C  N N 255 
LYS O      O  N N 256 
LYS CB     C  N N 257 
LYS CG     C  N N 258 
LYS CD     C  N N 259 
LYS CE     C  N N 260 
LYS NZ     N  N N 261 
LYS OXT    O  N N 262 
LYS H      H  N N 263 
LYS H2     H  N N 264 
LYS HA     H  N N 265 
LYS HB2    H  N N 266 
LYS HB3    H  N N 267 
LYS HG2    H  N N 268 
LYS HG3    H  N N 269 
LYS HD2    H  N N 270 
LYS HD3    H  N N 271 
LYS HE2    H  N N 272 
LYS HE3    H  N N 273 
LYS HZ1    H  N N 274 
LYS HZ2    H  N N 275 
LYS HZ3    H  N N 276 
LYS HXT    H  N N 277 
MET N      N  N N 278 
MET CA     C  N S 279 
MET C      C  N N 280 
MET O      O  N N 281 
MET CB     C  N N 282 
MET CG     C  N N 283 
MET SD     S  N N 284 
MET CE     C  N N 285 
MET OXT    O  N N 286 
MET H      H  N N 287 
MET H2     H  N N 288 
MET HA     H  N N 289 
MET HB2    H  N N 290 
MET HB3    H  N N 291 
MET HG2    H  N N 292 
MET HG3    H  N N 293 
MET HE1    H  N N 294 
MET HE2    H  N N 295 
MET HE3    H  N N 296 
MET HXT    H  N N 297 
MG  MG     MG N N 298 
PHE N      N  N N 299 
PHE CA     C  N S 300 
PHE C      C  N N 301 
PHE O      O  N N 302 
PHE CB     C  N N 303 
PHE CG     C  Y N 304 
PHE CD1    C  Y N 305 
PHE CD2    C  Y N 306 
PHE CE1    C  Y N 307 
PHE CE2    C  Y N 308 
PHE CZ     C  Y N 309 
PHE OXT    O  N N 310 
PHE H      H  N N 311 
PHE H2     H  N N 312 
PHE HA     H  N N 313 
PHE HB2    H  N N 314 
PHE HB3    H  N N 315 
PHE HD1    H  N N 316 
PHE HD2    H  N N 317 
PHE HE1    H  N N 318 
PHE HE2    H  N N 319 
PHE HZ     H  N N 320 
PHE HXT    H  N N 321 
PRO N      N  N N 322 
PRO CA     C  N S 323 
PRO C      C  N N 324 
PRO O      O  N N 325 
PRO CB     C  N N 326 
PRO CG     C  N N 327 
PRO CD     C  N N 328 
PRO OXT    O  N N 329 
PRO H      H  N N 330 
PRO HA     H  N N 331 
PRO HB2    H  N N 332 
PRO HB3    H  N N 333 
PRO HG2    H  N N 334 
PRO HG3    H  N N 335 
PRO HD2    H  N N 336 
PRO HD3    H  N N 337 
PRO HXT    H  N N 338 
SER N      N  N N 339 
SER CA     C  N S 340 
SER C      C  N N 341 
SER O      O  N N 342 
SER CB     C  N N 343 
SER OG     O  N N 344 
SER OXT    O  N N 345 
SER H      H  N N 346 
SER H2     H  N N 347 
SER HA     H  N N 348 
SER HB2    H  N N 349 
SER HB3    H  N N 350 
SER HG     H  N N 351 
SER HXT    H  N N 352 
THR N      N  N N 353 
THR CA     C  N S 354 
THR C      C  N N 355 
THR O      O  N N 356 
THR CB     C  N R 357 
THR OG1    O  N N 358 
THR CG2    C  N N 359 
THR OXT    O  N N 360 
THR H      H  N N 361 
THR H2     H  N N 362 
THR HA     H  N N 363 
THR HB     H  N N 364 
THR HG1    H  N N 365 
THR HG21   H  N N 366 
THR HG22   H  N N 367 
THR HG23   H  N N 368 
THR HXT    H  N N 369 
TRP N      N  N N 370 
TRP CA     C  N S 371 
TRP C      C  N N 372 
TRP O      O  N N 373 
TRP CB     C  N N 374 
TRP CG     C  Y N 375 
TRP CD1    C  Y N 376 
TRP CD2    C  Y N 377 
TRP NE1    N  Y N 378 
TRP CE2    C  Y N 379 
TRP CE3    C  Y N 380 
TRP CZ2    C  Y N 381 
TRP CZ3    C  Y N 382 
TRP CH2    C  Y N 383 
TRP OXT    O  N N 384 
TRP H      H  N N 385 
TRP H2     H  N N 386 
TRP HA     H  N N 387 
TRP HB2    H  N N 388 
TRP HB3    H  N N 389 
TRP HD1    H  N N 390 
TRP HE1    H  N N 391 
TRP HE3    H  N N 392 
TRP HZ2    H  N N 393 
TRP HZ3    H  N N 394 
TRP HH2    H  N N 395 
TRP HXT    H  N N 396 
TYR N      N  N N 397 
TYR CA     C  N S 398 
TYR C      C  N N 399 
TYR O      O  N N 400 
TYR CB     C  N N 401 
TYR CG     C  Y N 402 
TYR CD1    C  Y N 403 
TYR CD2    C  Y N 404 
TYR CE1    C  Y N 405 
TYR CE2    C  Y N 406 
TYR CZ     C  Y N 407 
TYR OH     O  N N 408 
TYR OXT    O  N N 409 
TYR H      H  N N 410 
TYR H2     H  N N 411 
TYR HA     H  N N 412 
TYR HB2    H  N N 413 
TYR HB3    H  N N 414 
TYR HD1    H  N N 415 
TYR HD2    H  N N 416 
TYR HE1    H  N N 417 
TYR HE2    H  N N 418 
TYR HH     H  N N 419 
TYR HXT    H  N N 420 
VAL N      N  N N 421 
VAL CA     C  N S 422 
VAL C      C  N N 423 
VAL O      O  N N 424 
VAL CB     C  N N 425 
VAL CG1    C  N N 426 
VAL CG2    C  N N 427 
VAL OXT    O  N N 428 
VAL H      H  N N 429 
VAL H2     H  N N 430 
VAL HA     H  N N 431 
VAL HB     H  N N 432 
VAL HG11   H  N N 433 
VAL HG12   H  N N 434 
VAL HG13   H  N N 435 
VAL HG21   H  N N 436 
VAL HG22   H  N N 437 
VAL HG23   H  N N 438 
VAL HXT    H  N N 439 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
GLN N     CA     sing N N 83  
GLN N     H      sing N N 84  
GLN N     H2     sing N N 85  
GLN CA    C      sing N N 86  
GLN CA    CB     sing N N 87  
GLN CA    HA     sing N N 88  
GLN C     O      doub N N 89  
GLN C     OXT    sing N N 90  
GLN CB    CG     sing N N 91  
GLN CB    HB2    sing N N 92  
GLN CB    HB3    sing N N 93  
GLN CG    CD     sing N N 94  
GLN CG    HG2    sing N N 95  
GLN CG    HG3    sing N N 96  
GLN CD    OE1    doub N N 97  
GLN CD    NE2    sing N N 98  
GLN NE2   HE21   sing N N 99  
GLN NE2   HE22   sing N N 100 
GLN OXT   HXT    sing N N 101 
GLU N     CA     sing N N 102 
GLU N     H      sing N N 103 
GLU N     H2     sing N N 104 
GLU CA    C      sing N N 105 
GLU CA    CB     sing N N 106 
GLU CA    HA     sing N N 107 
GLU C     O      doub N N 108 
GLU C     OXT    sing N N 109 
GLU CB    CG     sing N N 110 
GLU CB    HB2    sing N N 111 
GLU CB    HB3    sing N N 112 
GLU CG    CD     sing N N 113 
GLU CG    HG2    sing N N 114 
GLU CG    HG3    sing N N 115 
GLU CD    OE1    doub N N 116 
GLU CD    OE2    sing N N 117 
GLU OE2   HE2    sing N N 118 
GLU OXT   HXT    sing N N 119 
GLY N     CA     sing N N 120 
GLY N     H      sing N N 121 
GLY N     H2     sing N N 122 
GLY CA    C      sing N N 123 
GLY CA    HA2    sing N N 124 
GLY CA    HA3    sing N N 125 
GLY C     O      doub N N 126 
GLY C     OXT    sing N N 127 
GLY OXT   HXT    sing N N 128 
GTP PG    O1G    doub N N 129 
GTP PG    O2G    sing N N 130 
GTP PG    O3G    sing N N 131 
GTP PG    O3B    sing N N 132 
GTP O2G   HOG2   sing N N 133 
GTP O3G   HOG3   sing N N 134 
GTP O3B   PB     sing N N 135 
GTP PB    O1B    doub N N 136 
GTP PB    O2B    sing N N 137 
GTP PB    O3A    sing N N 138 
GTP O2B   HOB2   sing N N 139 
GTP O3A   PA     sing N N 140 
GTP PA    O1A    doub N N 141 
GTP PA    O2A    sing N N 142 
GTP PA    "O5'"  sing N N 143 
GTP O2A   HOA2   sing N N 144 
GTP "O5'" "C5'"  sing N N 145 
GTP "C5'" "C4'"  sing N N 146 
GTP "C5'" "H5'"  sing N N 147 
GTP "C5'" "H5''" sing N N 148 
GTP "C4'" "O4'"  sing N N 149 
GTP "C4'" "C3'"  sing N N 150 
GTP "C4'" "H4'"  sing N N 151 
GTP "O4'" "C1'"  sing N N 152 
GTP "C3'" "O3'"  sing N N 153 
GTP "C3'" "C2'"  sing N N 154 
GTP "C3'" "H3'"  sing N N 155 
GTP "O3'" "HO3'" sing N N 156 
GTP "C2'" "O2'"  sing N N 157 
GTP "C2'" "C1'"  sing N N 158 
GTP "C2'" "H2'"  sing N N 159 
GTP "O2'" "HO2'" sing N N 160 
GTP "C1'" N9     sing N N 161 
GTP "C1'" "H1'"  sing N N 162 
GTP N9    C8     sing Y N 163 
GTP N9    C4     sing Y N 164 
GTP C8    N7     doub Y N 165 
GTP C8    H8     sing N N 166 
GTP N7    C5     sing Y N 167 
GTP C5    C6     sing N N 168 
GTP C5    C4     doub Y N 169 
GTP C6    O6     doub N N 170 
GTP C6    N1     sing N N 171 
GTP N1    C2     sing N N 172 
GTP N1    HN1    sing N N 173 
GTP C2    N2     sing N N 174 
GTP C2    N3     doub N N 175 
GTP N2    HN21   sing N N 176 
GTP N2    HN22   sing N N 177 
GTP N3    C4     sing N N 178 
HIS N     CA     sing N N 179 
HIS N     H      sing N N 180 
HIS N     H2     sing N N 181 
HIS CA    C      sing N N 182 
HIS CA    CB     sing N N 183 
HIS CA    HA     sing N N 184 
HIS C     O      doub N N 185 
HIS C     OXT    sing N N 186 
HIS CB    CG     sing N N 187 
HIS CB    HB2    sing N N 188 
HIS CB    HB3    sing N N 189 
HIS CG    ND1    sing Y N 190 
HIS CG    CD2    doub Y N 191 
HIS ND1   CE1    doub Y N 192 
HIS ND1   HD1    sing N N 193 
HIS CD2   NE2    sing Y N 194 
HIS CD2   HD2    sing N N 195 
HIS CE1   NE2    sing Y N 196 
HIS CE1   HE1    sing N N 197 
HIS NE2   HE2    sing N N 198 
HIS OXT   HXT    sing N N 199 
HOH O     H1     sing N N 200 
HOH O     H2     sing N N 201 
ILE N     CA     sing N N 202 
ILE N     H      sing N N 203 
ILE N     H2     sing N N 204 
ILE CA    C      sing N N 205 
ILE CA    CB     sing N N 206 
ILE CA    HA     sing N N 207 
ILE C     O      doub N N 208 
ILE C     OXT    sing N N 209 
ILE CB    CG1    sing N N 210 
ILE CB    CG2    sing N N 211 
ILE CB    HB     sing N N 212 
ILE CG1   CD1    sing N N 213 
ILE CG1   HG12   sing N N 214 
ILE CG1   HG13   sing N N 215 
ILE CG2   HG21   sing N N 216 
ILE CG2   HG22   sing N N 217 
ILE CG2   HG23   sing N N 218 
ILE CD1   HD11   sing N N 219 
ILE CD1   HD12   sing N N 220 
ILE CD1   HD13   sing N N 221 
ILE OXT   HXT    sing N N 222 
LEU N     CA     sing N N 223 
LEU N     H      sing N N 224 
LEU N     H2     sing N N 225 
LEU CA    C      sing N N 226 
LEU CA    CB     sing N N 227 
LEU CA    HA     sing N N 228 
LEU C     O      doub N N 229 
LEU C     OXT    sing N N 230 
LEU CB    CG     sing N N 231 
LEU CB    HB2    sing N N 232 
LEU CB    HB3    sing N N 233 
LEU CG    CD1    sing N N 234 
LEU CG    CD2    sing N N 235 
LEU CG    HG     sing N N 236 
LEU CD1   HD11   sing N N 237 
LEU CD1   HD12   sing N N 238 
LEU CD1   HD13   sing N N 239 
LEU CD2   HD21   sing N N 240 
LEU CD2   HD22   sing N N 241 
LEU CD2   HD23   sing N N 242 
LEU OXT   HXT    sing N N 243 
LYS N     CA     sing N N 244 
LYS N     H      sing N N 245 
LYS N     H2     sing N N 246 
LYS CA    C      sing N N 247 
LYS CA    CB     sing N N 248 
LYS CA    HA     sing N N 249 
LYS C     O      doub N N 250 
LYS C     OXT    sing N N 251 
LYS CB    CG     sing N N 252 
LYS CB    HB2    sing N N 253 
LYS CB    HB3    sing N N 254 
LYS CG    CD     sing N N 255 
LYS CG    HG2    sing N N 256 
LYS CG    HG3    sing N N 257 
LYS CD    CE     sing N N 258 
LYS CD    HD2    sing N N 259 
LYS CD    HD3    sing N N 260 
LYS CE    NZ     sing N N 261 
LYS CE    HE2    sing N N 262 
LYS CE    HE3    sing N N 263 
LYS NZ    HZ1    sing N N 264 
LYS NZ    HZ2    sing N N 265 
LYS NZ    HZ3    sing N N 266 
LYS OXT   HXT    sing N N 267 
MET N     CA     sing N N 268 
MET N     H      sing N N 269 
MET N     H2     sing N N 270 
MET CA    C      sing N N 271 
MET CA    CB     sing N N 272 
MET CA    HA     sing N N 273 
MET C     O      doub N N 274 
MET C     OXT    sing N N 275 
MET CB    CG     sing N N 276 
MET CB    HB2    sing N N 277 
MET CB    HB3    sing N N 278 
MET CG    SD     sing N N 279 
MET CG    HG2    sing N N 280 
MET CG    HG3    sing N N 281 
MET SD    CE     sing N N 282 
MET CE    HE1    sing N N 283 
MET CE    HE2    sing N N 284 
MET CE    HE3    sing N N 285 
MET OXT   HXT    sing N N 286 
PHE N     CA     sing N N 287 
PHE N     H      sing N N 288 
PHE N     H2     sing N N 289 
PHE CA    C      sing N N 290 
PHE CA    CB     sing N N 291 
PHE CA    HA     sing N N 292 
PHE C     O      doub N N 293 
PHE C     OXT    sing N N 294 
PHE CB    CG     sing N N 295 
PHE CB    HB2    sing N N 296 
PHE CB    HB3    sing N N 297 
PHE CG    CD1    doub Y N 298 
PHE CG    CD2    sing Y N 299 
PHE CD1   CE1    sing Y N 300 
PHE CD1   HD1    sing N N 301 
PHE CD2   CE2    doub Y N 302 
PHE CD2   HD2    sing N N 303 
PHE CE1   CZ     doub Y N 304 
PHE CE1   HE1    sing N N 305 
PHE CE2   CZ     sing Y N 306 
PHE CE2   HE2    sing N N 307 
PHE CZ    HZ     sing N N 308 
PHE OXT   HXT    sing N N 309 
PRO N     CA     sing N N 310 
PRO N     CD     sing N N 311 
PRO N     H      sing N N 312 
PRO CA    C      sing N N 313 
PRO CA    CB     sing N N 314 
PRO CA    HA     sing N N 315 
PRO C     O      doub N N 316 
PRO C     OXT    sing N N 317 
PRO CB    CG     sing N N 318 
PRO CB    HB2    sing N N 319 
PRO CB    HB3    sing N N 320 
PRO CG    CD     sing N N 321 
PRO CG    HG2    sing N N 322 
PRO CG    HG3    sing N N 323 
PRO CD    HD2    sing N N 324 
PRO CD    HD3    sing N N 325 
PRO OXT   HXT    sing N N 326 
SER N     CA     sing N N 327 
SER N     H      sing N N 328 
SER N     H2     sing N N 329 
SER CA    C      sing N N 330 
SER CA    CB     sing N N 331 
SER CA    HA     sing N N 332 
SER C     O      doub N N 333 
SER C     OXT    sing N N 334 
SER CB    OG     sing N N 335 
SER CB    HB2    sing N N 336 
SER CB    HB3    sing N N 337 
SER OG    HG     sing N N 338 
SER OXT   HXT    sing N N 339 
THR N     CA     sing N N 340 
THR N     H      sing N N 341 
THR N     H2     sing N N 342 
THR CA    C      sing N N 343 
THR CA    CB     sing N N 344 
THR CA    HA     sing N N 345 
THR C     O      doub N N 346 
THR C     OXT    sing N N 347 
THR CB    OG1    sing N N 348 
THR CB    CG2    sing N N 349 
THR CB    HB     sing N N 350 
THR OG1   HG1    sing N N 351 
THR CG2   HG21   sing N N 352 
THR CG2   HG22   sing N N 353 
THR CG2   HG23   sing N N 354 
THR OXT   HXT    sing N N 355 
TRP N     CA     sing N N 356 
TRP N     H      sing N N 357 
TRP N     H2     sing N N 358 
TRP CA    C      sing N N 359 
TRP CA    CB     sing N N 360 
TRP CA    HA     sing N N 361 
TRP C     O      doub N N 362 
TRP C     OXT    sing N N 363 
TRP CB    CG     sing N N 364 
TRP CB    HB2    sing N N 365 
TRP CB    HB3    sing N N 366 
TRP CG    CD1    doub Y N 367 
TRP CG    CD2    sing Y N 368 
TRP CD1   NE1    sing Y N 369 
TRP CD1   HD1    sing N N 370 
TRP CD2   CE2    doub Y N 371 
TRP CD2   CE3    sing Y N 372 
TRP NE1   CE2    sing Y N 373 
TRP NE1   HE1    sing N N 374 
TRP CE2   CZ2    sing Y N 375 
TRP CE3   CZ3    doub Y N 376 
TRP CE3   HE3    sing N N 377 
TRP CZ2   CH2    doub Y N 378 
TRP CZ2   HZ2    sing N N 379 
TRP CZ3   CH2    sing Y N 380 
TRP CZ3   HZ3    sing N N 381 
TRP CH2   HH2    sing N N 382 
TRP OXT   HXT    sing N N 383 
TYR N     CA     sing N N 384 
TYR N     H      sing N N 385 
TYR N     H2     sing N N 386 
TYR CA    C      sing N N 387 
TYR CA    CB     sing N N 388 
TYR CA    HA     sing N N 389 
TYR C     O      doub N N 390 
TYR C     OXT    sing N N 391 
TYR CB    CG     sing N N 392 
TYR CB    HB2    sing N N 393 
TYR CB    HB3    sing N N 394 
TYR CG    CD1    doub Y N 395 
TYR CG    CD2    sing Y N 396 
TYR CD1   CE1    sing Y N 397 
TYR CD1   HD1    sing N N 398 
TYR CD2   CE2    doub Y N 399 
TYR CD2   HD2    sing N N 400 
TYR CE1   CZ     doub Y N 401 
TYR CE1   HE1    sing N N 402 
TYR CE2   CZ     sing Y N 403 
TYR CE2   HE2    sing N N 404 
TYR CZ    OH     sing N N 405 
TYR OH    HH     sing N N 406 
TYR OXT   HXT    sing N N 407 
VAL N     CA     sing N N 408 
VAL N     H      sing N N 409 
VAL N     H2     sing N N 410 
VAL CA    C      sing N N 411 
VAL CA    CB     sing N N 412 
VAL CA    HA     sing N N 413 
VAL C     O      doub N N 414 
VAL C     OXT    sing N N 415 
VAL CB    CG1    sing N N 416 
VAL CB    CG2    sing N N 417 
VAL CB    HB     sing N N 418 
VAL CG1   HG11   sing N N 419 
VAL CG1   HG12   sing N N 420 
VAL CG1   HG13   sing N N 421 
VAL CG2   HG21   sing N N 422 
VAL CG2   HG22   sing N N 423 
VAL CG2   HG23   sing N N 424 
VAL OXT   HXT    sing N N 425 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           111-2311-B-039-001-MY3 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'apo DwCdnB' 
# 
_atom_sites.entry_id                    8YSG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028545 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.005870 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009960 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022004 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H  1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
MG 12 12 5.427  2.828  2.176 79.261 1.228 0.381  2.310 7.194  0.859   
N  7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O  8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
P  15 15 6.435  1.907  4.179 27.157 1.780 0.526  1.491 68.164 1.115   
S  16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N     . VAL A 1 4   ? 18.862  -22.315 20.714  1.000 41.049  ? 4   VAL A N     1 ? 
ATOM   2    C  CA    . VAL A 1 4   ? 19.187  -20.867 20.993  1.000 39.500  ? 4   VAL A CA    1 ? 
ATOM   3    C  C     . VAL A 1 4   ? 17.919  -19.996 20.948  1.000 34.710  ? 4   VAL A C     1 ? 
ATOM   4    O  O     . VAL A 1 4   ? 18.098  -18.764 20.835  1.000 33.851  ? 4   VAL A O     1 ? 
ATOM   5    C  CB    . VAL A 1 4   ? 20.241  -20.313 20.006  1.000 41.799  ? 4   VAL A CB    1 ? 
ATOM   6    C  CG1   . VAL A 1 4   ? 21.596  -20.979 20.170  1.000 44.142  ? 4   VAL A CG1   1 ? 
ATOM   7    C  CG2   . VAL A 1 4   ? 19.784  -20.406 18.559  1.000 44.455  ? 4   VAL A CG2   1 ? 
ATOM   8    N  N     . GLN A 1 5   ? 16.714  -20.589 21.069  1.000 31.969  ? 5   GLN A N     1 ? 
ATOM   9    C  CA    . GLN A 1 5   ? 15.398  -19.903 20.956  1.000 31.619  ? 5   GLN A CA    1 ? 
ATOM   10   C  C     . GLN A 1 5   ? 15.221  -18.923 22.124  1.000 36.068  ? 5   GLN A C     1 ? 
ATOM   11   O  O     . GLN A 1 5   ? 14.999  -17.719 21.844  1.000 34.724  ? 5   GLN A O     1 ? 
ATOM   12   C  CB    . GLN A 1 5   ? 14.250  -20.917 20.900  1.000 31.479  ? 5   GLN A CB    1 ? 
ATOM   13   C  CG    . GLN A 1 5   ? 12.841  -20.302 20.832  1.000 28.806  ? 5   GLN A CG    1 ? 
ATOM   14   C  CD    . GLN A 1 5   ? 12.497  -19.729 19.475  1.000 27.705  ? 5   GLN A CD    1 ? 
ATOM   15   O  OE1   . GLN A 1 5   ? 13.292  -19.748 18.537  1.000 31.416  ? 5   GLN A OE1   1 ? 
ATOM   16   N  NE2   . GLN A 1 5   ? 11.317  -19.167 19.362  1.000 25.131  ? 5   GLN A NE2   1 ? 
ATOM   17   N  N     . LYS A 1 6   ? 15.329  -19.387 23.377  1.000 37.412  ? 6   LYS A N     1 ? 
ATOM   18   C  CA    . LYS A 1 6   ? 15.034  -18.548 24.573  1.000 41.439  ? 6   LYS A CA    1 ? 
ATOM   19   C  C     . LYS A 1 6   ? 15.921  -17.300 24.539  1.000 39.325  ? 6   LYS A C     1 ? 
ATOM   20   O  O     . LYS A 1 6   ? 15.456  -16.240 25.000  1.000 44.731  ? 6   LYS A O     1 ? 
ATOM   21   C  CB    . LYS A 1 6   ? 15.197  -19.339 25.875  1.000 49.057  ? 6   LYS A CB    1 ? 
ATOM   22   C  CG    . LYS A 1 6   ? 14.071  -20.328 26.161  1.000 55.470  ? 6   LYS A CG    1 ? 
ATOM   23   C  CD    . LYS A 1 6   ? 14.429  -21.353 27.215  1.000 58.678  ? 6   LYS A CD    1 ? 
ATOM   24   C  CE    . LYS A 1 6   ? 13.976  -22.755 26.873  1.000 60.376  ? 6   LYS A CE    1 ? 
ATOM   25   N  NZ    . LYS A 1 6   ? 14.774  -23.768 27.608  1.000 65.760  ? 6   LYS A NZ    1 ? 
ATOM   26   N  N     . GLN A 1 7   ? 17.095  -17.397 23.914  1.000 33.760  ? 7   GLN A N     1 ? 
ATOM   27   C  CA    . GLN A 1 7   ? 18.026  -16.258 23.731  1.000 34.396  ? 7   GLN A CA    1 ? 
ATOM   28   C  C     . GLN A 1 7   ? 17.431  -15.277 22.713  1.000 30.113  ? 7   GLN A C     1 ? 
ATOM   29   O  O     . GLN A 1 7   ? 17.508  -14.056 22.962  1.000 25.256  ? 7   GLN A O     1 ? 
ATOM   30   C  CB    . GLN A 1 7   ? 19.408  -16.761 23.298  1.000 39.295  ? 7   GLN A CB    1 ? 
ATOM   31   C  CG    . GLN A 1 7   ? 19.900  -17.971 24.102  1.000 42.693  ? 7   GLN A CG    1 ? 
ATOM   32   C  CD    . GLN A 1 7   ? 20.167  -17.650 25.552  1.000 41.338  ? 7   GLN A CD    1 ? 
ATOM   33   O  OE1   . GLN A 1 7   ? 20.499  -16.521 25.920  1.000 42.473  ? 7   GLN A OE1   1 ? 
ATOM   34   N  NE2   . GLN A 1 7   ? 20.076  -18.664 26.388  1.000 43.080  ? 7   GLN A NE2   1 ? 
ATOM   35   N  N     . PHE A 1 8   ? 16.852  -15.786 21.616  1.000 27.948  ? 8   PHE A N     1 ? 
ATOM   36   C  CA    . PHE A 1 8   ? 16.211  -14.952 20.552  1.000 25.519  ? 8   PHE A CA    1 ? 
ATOM   37   C  C     . PHE A 1 8   ? 14.981  -14.255 21.143  1.000 22.798  ? 8   PHE A C     1 ? 
ATOM   38   O  O     . PHE A 1 8   ? 14.773  -13.049 20.861  1.000 22.349  ? 8   PHE A O     1 ? 
ATOM   39   C  CB    . PHE A 1 8   ? 15.870  -15.769 19.294  1.000 23.089  ? 8   PHE A CB    1 ? 
ATOM   40   C  CG    . PHE A 1 8   ? 16.968  -15.807 18.252  1.000 22.533  ? 8   PHE A CG    1 ? 
ATOM   41   C  CD1   . PHE A 1 8   ? 17.174  -14.736 17.391  1.000 21.189  ? 8   PHE A CD1   1 ? 
ATOM   42   C  CD2   . PHE A 1 8   ? 17.815  -16.904 18.148  1.000 22.112  ? 8   PHE A CD2   1 ? 
ATOM   43   C  CE1   . PHE A 1 8   ? 18.196  -14.762 16.458  1.000 21.401  ? 8   PHE A CE1   1 ? 
ATOM   44   C  CE2   . PHE A 1 8   ? 18.830  -16.930 17.207  1.000 20.995  ? 8   PHE A CE2   1 ? 
ATOM   45   C  CZ    . PHE A 1 8   ? 19.024  -15.857 16.370  1.000 22.001  ? 8   PHE A CZ    1 ? 
ATOM   46   N  N     . ARG A 1 9   ? 14.235  -14.959 21.989  1.000 20.126  ? 9   ARG A N     1 ? 
ATOM   47   C  CA    . ARG A 1 9   ? 13.062  -14.383 22.685  1.000 22.139  ? 9   ARG A CA    1 ? 
ATOM   48   C  C     . ARG A 1 9   ? 13.523  -13.297 23.663  1.000 20.807  ? 9   ARG A C     1 ? 
ATOM   49   O  O     . ARG A 1 9   ? 12.934  -12.206 23.651  1.000 21.142  ? 9   ARG A O     1 ? 
ATOM   50   C  CB    . ARG A 1 9   ? 12.228  -15.489 23.320  1.000 23.011  ? 9   ARG A CB    1 ? 
ATOM   51   C  CG    . ARG A 1 9   ? 11.542  -16.396 22.302  1.000 23.517  ? 9   ARG A CG    1 ? 
ATOM   52   C  CD    . ARG A 1 9   ? 10.599  -15.693 21.333  1.000 24.625  ? 9   ARG A CD    1 ? 
ATOM   53   N  NE    . ARG A 1 9   ? 9.476   -14.994 21.965  1.000 24.266  ? 9   ARG A NE    1 ? 
ATOM   54   C  CZ    . ARG A 1 9   ? 8.238   -15.478 22.086  1.000 24.323  ? 9   ARG A CZ    1 ? 
ATOM   55   N  NH1   . ARG A 1 9   ? 7.936   -16.672 21.622  1.000 24.923  ? 9   ARG A NH1   1 ? 
ATOM   56   N  NH2   . ARG A 1 9   ? 7.292   -14.755 22.651  1.000 25.207  ? 9   ARG A NH2   1 ? 
ATOM   57   N  N     . GLU A 1 10  ? 14.566  -13.531 24.439  1.000 19.730  ? 10  GLU A N     1 ? 
ATOM   58   C  CA    . GLU A 1 10  ? 15.127  -12.458 25.289  1.000 20.202  ? 10  GLU A CA    1 ? 
ATOM   59   C  C     . GLU A 1 10  ? 15.564  -11.287 24.388  1.000 19.743  ? 10  GLU A C     1 ? 
ATOM   60   O  O     . GLU A 1 10  ? 15.073  -10.161 24.588  1.000 19.165  ? 10  GLU A O     1 ? 
ATOM   61   C  CB    . GLU A 1 10  ? 16.260  -13.005 26.165  1.000 22.010  ? 10  GLU A CB    1 ? 
ATOM   62   C  CG    . GLU A 1 10  ? 16.926  -11.942 27.022  1.000 22.469  ? 10  GLU A CG    1 ? 
ATOM   63   C  CD    . GLU A 1 10  ? 15.995  -11.130 27.906  1.000 22.695  ? 10  GLU A CD    1 ? 
ATOM   64   O  OE1   . GLU A 1 10  ? 14.879  -11.623 28.192  1.000 23.757  ? 10  GLU A OE1   1 ? 
ATOM   65   O  OE2   . GLU A 1 10  ? 16.390  -9.995  28.320  1.000 23.147  ? 10  GLU A OE2   1 ? 
ATOM   66   N  N     . PHE A 1 11  ? 16.431  -11.543 23.400  1.000 19.336  ? 11  PHE A N     1 ? 
ATOM   67   C  CA    . PHE A 1 11  ? 16.864  -10.540 22.389  1.000 16.907  ? 11  PHE A CA    1 ? 
ATOM   68   C  C     . PHE A 1 11  ? 15.661  -9.709  21.917  1.000 15.824  ? 11  PHE A C     1 ? 
ATOM   69   O  O     . PHE A 1 11  ? 15.729  -8.478  21.918  1.000 14.760  ? 11  PHE A O     1 ? 
ATOM   70   C  CB    . PHE A 1 11  ? 17.554  -11.214 21.203  1.000 16.422  ? 11  PHE A CB    1 ? 
ATOM   71   C  CG    . PHE A 1 11  ? 18.170  -10.247 20.221  1.000 15.925  ? 11  PHE A CG    1 ? 
ATOM   72   C  CD1   . PHE A 1 11  ? 19.008  -9.240  20.655  1.000 15.003  ? 11  PHE A CD1   1 ? 
ATOM   73   C  CD2   . PHE A 1 11  ? 17.915  -10.347 18.863  1.000 16.149  ? 11  PHE A CD2   1 ? 
ATOM   74   C  CE1   . PHE A 1 11  ? 19.572  -8.345  19.761  1.000 15.344  ? 11  PHE A CE1   1 ? 
ATOM   75   C  CE2   . PHE A 1 11  ? 18.488  -9.451  17.972  1.000 14.536  ? 11  PHE A CE2   1 ? 
ATOM   76   C  CZ    . PHE A 1 11  ? 19.324  -8.464  18.417  1.000 13.913  ? 11  PHE A CZ    1 ? 
ATOM   77   N  N     . HIS A 1 12  ? 14.597  -10.372 21.491  1.000 16.195  ? 12  HIS A N     1 ? 
ATOM   78   C  CA    . HIS A 1 12  ? 13.364  -9.719  20.996  1.000 17.417  ? 12  HIS A CA    1 ? 
ATOM   79   C  C     . HIS A 1 12  ? 12.846  -8.751  22.060  1.000 18.627  ? 12  HIS A C     1 ? 
ATOM   80   O  O     . HIS A 1 12  ? 12.731  -7.510  21.762  1.000 19.006  ? 12  HIS A O     1 ? 
ATOM   81   C  CB    . HIS A 1 12  ? 12.335  -10.759 20.558  1.000 17.805  ? 12  HIS A CB    1 ? 
ATOM   82   C  CG    . HIS A 1 12  ? 11.090  -10.116 20.082  1.000 18.831  ? 12  HIS A CG    1 ? 
ATOM   83   N  ND1   . HIS A 1 12  ? 9.916   -10.164 20.812  1.000 20.879  ? 12  HIS A ND1   1 ? 
ATOM   84   C  CD2   . HIS A 1 12  ? 10.850  -9.342  19.002  1.000 18.738  ? 12  HIS A CD2   1 ? 
ATOM   85   C  CE1   . HIS A 1 12  ? 8.994   -9.455  20.192  1.000 22.776  ? 12  HIS A CE1   1 ? 
ATOM   86   N  NE2   . HIS A 1 12  ? 9.537   -8.943  19.066  1.000 20.217  ? 12  HIS A NE2   1 ? 
ATOM   87   N  N     . ASP A 1 13  ? 12.698  -9.224  23.302  1.000 20.289  ? 13  ASP A N     1 ? 
ATOM   88   C  CA    . ASP A 1 13  ? 12.176  -8.373  24.406  1.000 20.143  ? 13  ASP A CA    1 ? 
ATOM   89   C  C     . ASP A 1 13  ? 13.058  -7.144  24.534  1.000 18.605  ? 13  ASP A C     1 ? 
ATOM   90   O  O     . ASP A 1 13  ? 12.511  -6.062  24.740  1.000 16.367  ? 13  ASP A O     1 ? 
ATOM   91   C  CB    . ASP A 1 13  ? 12.028  -9.143  25.719  1.000 24.183  ? 13  ASP A CB    1 ? 
ATOM   92   C  CG    . ASP A 1 13  ? 10.955  -10.215 25.644  1.000 24.967  ? 13  ASP A CG    1 ? 
ATOM   93   O  OD1   . ASP A 1 13  ? 10.140  -10.166 24.698  1.000 26.081  ? 13  ASP A OD1   1 ? 
ATOM   94   O  OD2   . ASP A 1 13  ? 10.983  -11.124 26.477  1.000 26.102  ? 13  ASP A OD2   1 ? 
ATOM   95   N  N     . ARG A 1 14  ? 14.375  -7.292  24.367  1.000 19.101  ? 14  ARG A N     1 ? 
ATOM   96   C  CA    . ARG A 1 14  ? 15.317  -6.166  24.550  1.000 19.225  ? 14  ARG A CA    1 ? 
ATOM   97   C  C     . ARG A 1 14  ? 15.201  -5.170  23.408  1.000 19.425  ? 14  ARG A C     1 ? 
ATOM   98   O  O     . ARG A 1 14  ? 15.578  -4.024  23.624  1.000 20.877  ? 14  ARG A O     1 ? 
ATOM   99   C  CB    . ARG A 1 14  ? 16.769  -6.613  24.598  1.000 21.069  ? 14  ARG A CB    1 ? 
ATOM   100  C  CG    . ARG A 1 14  ? 17.087  -7.516  25.770  1.000 22.287  ? 14  ARG A CG    1 ? 
ATOM   101  C  CD    . ARG A 1 14  ? 18.531  -7.945  25.729  1.000 22.269  ? 14  ARG A CD    1 ? 
ATOM   102  N  NE    . ARG A 1 14  ? 18.706  -8.871  26.810  1.000 25.909  ? 14  ARG A NE    1 ? 
ATOM   103  C  CZ    . ARG A 1 14  ? 19.851  -9.399  27.188  1.000 27.769  ? 14  ARG A CZ    1 ? 
ATOM   104  N  NH1   . ARG A 1 14  ? 20.962  -9.110  26.534  1.000 27.838  ? 14  ARG A NH1   1 ? 
ATOM   105  N  NH2   . ARG A 1 14  ? 19.867  -10.251 28.203  1.000 28.052  ? 14  ARG A NH2   1 ? 
ATOM   106  N  N     . ILE A 1 15  ? 14.852  -5.605  22.199  1.000 19.235  ? 15  ILE A N     1 ? 
ATOM   107  C  CA    . ILE A 1 15  ? 15.010  -4.718  21.015  1.000 19.009  ? 15  ILE A CA    1 ? 
ATOM   108  C  C     . ILE A 1 15  ? 13.658  -4.138  20.617  1.000 18.126  ? 15  ILE A C     1 ? 
ATOM   109  O  O     . ILE A 1 15  ? 13.672  -3.076  20.035  1.000 17.286  ? 15  ILE A O     1 ? 
ATOM   110  C  CB    . ILE A 1 15  ? 15.678  -5.455  19.847  1.000 20.974  ? 15  ILE A CB    1 ? 
ATOM   111  C  CG1   . ILE A 1 15  ? 14.730  -6.477  19.205  1.000 20.014  ? 15  ILE A CG1   1 ? 
ATOM   112  C  CG2   . ILE A 1 15  ? 17.005  -6.066  20.297  1.000 21.800  ? 15  ILE A CG2   1 ? 
ATOM   113  C  CD1   . ILE A 1 15  ? 15.322  -7.213  18.019  1.000 22.289  ? 15  ILE A CD1   1 ? 
ATOM   114  N  N     . LYS A 1 16  ? 12.552  -4.843  20.868  1.000 20.717  ? 16  LYS A N     1 ? 
ATOM   115  C  CA    . LYS A 1 16  ? 11.223  -4.424  20.373  1.000 22.931  ? 16  LYS A CA    1 ? 
ATOM   116  C  C     . LYS A 1 16  ? 10.893  -3.064  20.993  1.000 25.280  ? 16  LYS A C     1 ? 
ATOM   117  O  O     . LYS A 1 16  ? 11.220  -2.839  22.189  1.000 23.734  ? 16  LYS A O     1 ? 
ATOM   118  C  CB    . LYS A 1 16  ? 10.157  -5.481  20.650  1.000 25.547  ? 16  LYS A CB    1 ? 
ATOM   119  C  CG    . LYS A 1 16  ? 9.395   -5.322  21.959  1.000 30.098  ? 16  LYS A CG    1 ? 
ATOM   120  C  CD    . LYS A 1 16  ? 8.768   -6.612  22.478  1.000 31.139  ? 16  LYS A CD    1 ? 
ATOM   121  C  CE    . LYS A 1 16  ? 8.553   -6.576  23.983  1.000 38.352  ? 16  LYS A CE    1 ? 
ATOM   122  N  NZ    . LYS A 1 16  ? 8.614   -7.924  24.602  1.000 39.663  ? 16  LYS A NZ    1 ? 
ATOM   123  N  N     . LEU A 1 17  ? 10.331  -2.169  20.189  1.000 27.099  ? 17  LEU A N     1 ? 
ATOM   124  C  CA    . LEU A 1 17  ? 9.827   -0.855  20.644  1.000 27.211  ? 17  LEU A CA    1 ? 
ATOM   125  C  C     . LEU A 1 17  ? 8.332   -0.814  20.390  1.000 28.789  ? 17  LEU A C     1 ? 
ATOM   126  O  O     . LEU A 1 17  ? 7.919   -1.068  19.226  1.000 27.576  ? 17  LEU A O     1 ? 
ATOM   127  C  CB    . LEU A 1 17  ? 10.551  0.249   19.881  1.000 30.491  ? 17  LEU A CB    1 ? 
ATOM   128  C  CG    . LEU A 1 17  ? 10.012  1.661   20.076  1.000 31.436  ? 17  LEU A CG    1 ? 
ATOM   129  C  CD1   . LEU A 1 17  ? 10.154  2.115   21.519  1.000 33.496  ? 17  LEU A CD1   1 ? 
ATOM   130  C  CD2   . LEU A 1 17  ? 10.719  2.617   19.145  1.000 32.728  ? 17  LEU A CD2   1 ? 
ATOM   131  N  N     . ALA A 1 18  ? 7.557   -0.519  21.433  1.000 28.978  ? 18  ALA A N     1 ? 
ATOM   132  C  CA    . ALA A 1 18  ? 6.080   -0.426  21.393  1.000 29.922  ? 18  ALA A CA    1 ? 
ATOM   133  C  C     . ALA A 1 18  ? 5.630   0.512   20.254  1.000 26.434  ? 18  ALA A C     1 ? 
ATOM   134  O  O     . ALA A 1 18  ? 6.158   1.608   20.148  1.000 24.313  ? 18  ALA A O     1 ? 
ATOM   135  C  CB    . ALA A 1 18  ? 5.575   0.015   22.744  1.000 30.440  ? 18  ALA A CB    1 ? 
ATOM   136  N  N     . GLN A 1 19  ? 4.709   0.041   19.409  1.000 30.585  ? 19  GLN A N     1 ? 
ATOM   137  C  CA    . GLN A 1 19  ? 4.076   0.788   18.274  1.000 34.999  ? 19  GLN A CA    1 ? 
ATOM   138  C  C     . GLN A 1 19  ? 3.392   2.080   18.752  1.000 39.677  ? 19  GLN A C     1 ? 
ATOM   139  O  O     . GLN A 1 19  ? 3.119   2.207   19.954  1.000 41.313  ? 19  GLN A O     1 ? 
ATOM   140  C  CB    . GLN A 1 19  ? 3.014   -0.095  17.614  1.000 39.292  ? 19  GLN A CB    1 ? 
ATOM   141  C  CG    . GLN A 1 19  ? 1.968   -0.651  18.582  1.000 38.818  ? 19  GLN A CG    1 ? 
ATOM   142  C  CD    . GLN A 1 19  ? 1.110   -1.709  17.934  1.000 40.018  ? 19  GLN A CD    1 ? 
ATOM   143  O  OE1   . GLN A 1 19  ? 0.516   -1.480  16.885  1.000 37.244  ? 19  GLN A OE1   1 ? 
ATOM   144  N  NE2   . GLN A 1 19  ? 1.047   -2.884  18.552  1.000 39.227  ? 19  GLN A NE2   1 ? 
ATOM   145  N  N     . TYR A 1 20  ? 3.060   2.979   17.826  1.000 46.104  ? 20  TYR A N     1 ? 
ATOM   146  C  CA    . TYR A 1 20  ? 2.346   4.255   18.119  1.000 48.320  ? 20  TYR A CA    1 ? 
ATOM   147  C  C     . TYR A 1 20  ? 1.193   3.999   19.117  1.000 52.440  ? 20  TYR A C     1 ? 
ATOM   148  O  O     . TYR A 1 20  ? 1.085   4.740   20.116  1.000 50.168  ? 20  TYR A O     1 ? 
ATOM   149  C  CB    . TYR A 1 20  ? 1.822   4.900   16.831  1.000 48.130  ? 20  TYR A CB    1 ? 
ATOM   150  C  CG    . TYR A 1 20  ? 2.854   5.542   15.926  1.000 44.383  ? 20  TYR A CG    1 ? 
ATOM   151  C  CD1   . TYR A 1 20  ? 3.782   6.456   16.400  1.000 43.919  ? 20  TYR A CD1   1 ? 
ATOM   152  C  CD2   . TYR A 1 20  ? 2.861   5.268   14.570  1.000 42.738  ? 20  TYR A CD2   1 ? 
ATOM   153  C  CE1   . TYR A 1 20  ? 4.709   7.051   15.552  1.000 45.244  ? 20  TYR A CE1   1 ? 
ATOM   154  C  CE2   . TYR A 1 20  ? 3.776   5.852   13.709  1.000 43.189  ? 20  TYR A CE2   1 ? 
ATOM   155  C  CZ    . TYR A 1 20  ? 4.707   6.747   14.198  1.000 42.685  ? 20  TYR A CZ    1 ? 
ATOM   156  O  OH    . TYR A 1 20  ? 5.593   7.315   13.326  1.000 39.699  ? 20  TYR A OH    1 ? 
ATOM   157  N  N     . ASP A 1 21  ? 0.378   2.965   18.870  1.000 52.978  ? 21  ASP A N     1 ? 
ATOM   158  C  CA    . ASP A 1 21  ? -0.830  2.622   19.674  1.000 53.945  ? 21  ASP A CA    1 ? 
ATOM   159  C  C     . ASP A 1 21  ? -0.467  2.354   21.148  1.000 56.627  ? 21  ASP A C     1 ? 
ATOM   160  O  O     . ASP A 1 21  ? -1.307  2.674   22.014  1.000 61.807  ? 21  ASP A O     1 ? 
ATOM   161  C  CB    . ASP A 1 21  ? -1.553  1.397   19.107  1.000 54.166  ? 21  ASP A CB    1 ? 
ATOM   162  C  CG    . ASP A 1 21  ? -2.164  1.593   17.729  1.000 55.293  ? 21  ASP A CG    1 ? 
ATOM   163  O  OD1   . ASP A 1 21  ? -2.539  0.572   17.116  1.000 54.240  ? 21  ASP A OD1   1 ? 
ATOM   164  O  OD2   . ASP A 1 21  ? -2.271  2.760   17.281  1.000 54.822  ? 21  ASP A OD2   1 ? 
ATOM   165  N  N     . GLU A 1 22  ? 0.698   1.743   21.425  1.000 54.395  ? 22  GLU A N     1 ? 
ATOM   166  C  CA    . GLU A 1 22  ? 1.084   1.223   22.772  1.000 46.548  ? 22  GLU A CA    1 ? 
ATOM   167  C  C     . GLU A 1 22  ? 2.211   2.070   23.375  1.000 43.937  ? 22  GLU A C     1 ? 
ATOM   168  O  O     . GLU A 1 22  ? 2.800   1.618   24.368  1.000 42.498  ? 22  GLU A O     1 ? 
ATOM   169  C  CB    . GLU A 1 22  ? 1.585   -0.217  22.675  1.000 47.718  ? 22  GLU A CB    1 ? 
ATOM   170  C  CG    . GLU A 1 22  ? 0.650   -1.151  21.936  1.000 49.558  ? 22  GLU A CG    1 ? 
ATOM   171  C  CD    . GLU A 1 22  ? 1.121   -2.592  21.944  1.000 50.074  ? 22  GLU A CD    1 ? 
ATOM   172  O  OE1   . GLU A 1 22  ? 1.250   -3.161  23.042  1.000 54.695  ? 22  GLU A OE1   1 ? 
ATOM   173  O  OE2   . GLU A 1 22  ? 1.388   -3.130  20.859  1.000 51.711  ? 22  GLU A OE2   1 ? 
ATOM   174  N  N     . ASN A 1 23  ? 2.524   3.226   22.781  1.000 39.736  ? 23  ASN A N     1 ? 
ATOM   175  C  CA    . ASN A 1 23  ? 3.737   4.020   23.109  1.000 44.259  ? 23  ASN A CA    1 ? 
ATOM   176  C  C     . ASN A 1 23  ? 3.389   5.507   23.249  1.000 51.542  ? 23  ASN A C     1 ? 
ATOM   177  O  O     . ASN A 1 23  ? 3.826   6.312   22.378  1.000 48.784  ? 23  ASN A O     1 ? 
ATOM   178  C  CB    . ASN A 1 23  ? 4.839   3.813   22.069  1.000 44.951  ? 23  ASN A CB    1 ? 
ATOM   179  C  CG    . ASN A 1 23  ? 6.199   4.232   22.584  1.000 44.305  ? 23  ASN A CG    1 ? 
ATOM   180  O  OD1   . ASN A 1 23  ? 6.309   5.231   23.298  1.000 42.055  ? 23  ASN A OD1   1 ? 
ATOM   181  N  ND2   . ASN A 1 23  ? 7.230   3.463   22.256  1.000 41.582  ? 23  ASN A ND2   1 ? 
ATOM   182  N  N     . GLN A 1 24  ? 2.706   5.863   24.347  1.000 57.218  ? 24  GLN A N     1 ? 
ATOM   183  C  CA    . GLN A 1 24  ? 2.310   7.255   24.709  1.000 59.069  ? 24  GLN A CA    1 ? 
ATOM   184  C  C     . GLN A 1 24  ? 3.375   8.250   24.217  1.000 53.522  ? 24  GLN A C     1 ? 
ATOM   185  O  O     . GLN A 1 24  ? 3.021   9.195   23.488  1.000 56.593  ? 24  GLN A O     1 ? 
ATOM   186  C  CB    . GLN A 1 24  ? 2.118   7.364   26.225  1.000 64.285  ? 24  GLN A CB    1 ? 
ATOM   187  C  CG    . GLN A 1 24  ? 1.448   8.660   26.670  1.000 66.973  ? 24  GLN A CG    1 ? 
ATOM   188  C  CD    . GLN A 1 24  ? -0.055  8.551   26.655  1.000 66.487  ? 24  GLN A CD    1 ? 
ATOM   189  O  OE1   . GLN A 1 24  ? -0.716  8.980   25.713  1.000 66.794  ? 24  GLN A OE1   1 ? 
ATOM   190  N  NE2   . GLN A 1 24  ? -0.605  7.946   27.696  1.000 63.856  ? 24  GLN A NE2   1 ? 
ATOM   191  N  N     . THR A 1 25  ? 4.634   8.022   24.578  1.000 51.019  ? 25  THR A N     1 ? 
ATOM   192  C  CA    . THR A 1 25  ? 5.723   9.031   24.503  1.000 53.074  ? 25  THR A CA    1 ? 
ATOM   193  C  C     . THR A 1 25  ? 6.114   9.282   23.029  1.000 50.417  ? 25  THR A C     1 ? 
ATOM   194  O  O     . THR A 1 25  ? 6.559   10.413  22.738  1.000 48.783  ? 25  THR A O     1 ? 
ATOM   195  C  CB    . THR A 1 25  ? 6.858   8.654   25.473  1.000 55.344  ? 25  THR A CB    1 ? 
ATOM   196  O  OG1   . THR A 1 25  ? 7.937   9.577   25.305  1.000 53.265  ? 25  THR A OG1   1 ? 
ATOM   197  C  CG2   . THR A 1 25  ? 7.362   7.237   25.309  1.000 54.996  ? 25  THR A CG2   1 ? 
ATOM   198  N  N     . LEU A 1 26  ? 5.874   8.317   22.126  1.000 50.434  ? 26  LEU A N     1 ? 
ATOM   199  C  CA    . LEU A 1 26  ? 6.154   8.432   20.664  1.000 45.585  ? 26  LEU A CA    1 ? 
ATOM   200  C  C     . LEU A 1 26  ? 5.042   9.223   19.965  1.000 47.036  ? 26  LEU A C     1 ? 
ATOM   201  O  O     . LEU A 1 26  ? 5.371   9.963   19.002  1.000 41.266  ? 26  LEU A O     1 ? 
ATOM   202  C  CB    . LEU A 1 26  ? 6.283   7.038   20.041  1.000 48.612  ? 26  LEU A CB    1 ? 
ATOM   203  C  CG    . LEU A 1 26  ? 7.684   6.418   20.071  1.000 51.815  ? 26  LEU A CG    1 ? 
ATOM   204  C  CD1   . LEU A 1 26  ? 7.665   5.018   19.481  1.000 54.022  ? 26  LEU A CD1   1 ? 
ATOM   205  C  CD2   . LEU A 1 26  ? 8.699   7.282   19.331  1.000 49.756  ? 26  LEU A CD2   1 ? 
ATOM   206  N  N     . ARG A 1 27  ? 3.780   9.043   20.393  1.000 46.740  ? 27  ARG A N     1 ? 
ATOM   207  C  CA    . ARG A 1 27  ? 2.612   9.819   19.885  1.000 46.832  ? 27  ARG A CA    1 ? 
ATOM   208  C  C     . ARG A 1 27  ? 2.856   11.302  20.164  1.000 47.810  ? 27  ARG A C     1 ? 
ATOM   209  O  O     . ARG A 1 27  ? 2.571   12.115  19.277  1.000 48.167  ? 27  ARG A O     1 ? 
ATOM   210  C  CB    . ARG A 1 27  ? 1.290   9.381   20.524  1.000 42.781  ? 27  ARG A CB    1 ? 
ATOM   211  C  CG    . ARG A 1 27  ? 0.904   7.947   20.211  1.000 45.212  ? 27  ARG A CG    1 ? 
ATOM   212  C  CD    . ARG A 1 27  ? -0.552  7.619   20.504  1.000 45.892  ? 27  ARG A CD    1 ? 
ATOM   213  N  NE    . ARG A 1 27  ? -0.853  7.637   21.931  1.000 43.231  ? 27  ARG A NE    1 ? 
ATOM   214  C  CZ    . ARG A 1 27  ? -0.534  6.683   22.801  1.000 39.978  ? 27  ARG A CZ    1 ? 
ATOM   215  N  NH1   . ARG A 1 27  ? 0.118   5.604   22.407  1.000 39.801  ? 27  ARG A NH1   1 ? 
ATOM   216  N  NH2   . ARG A 1 27  ? -0.868  6.819   24.075  1.000 39.616  ? 27  ARG A NH2   1 ? 
ATOM   217  N  N     . ASP A 1 28  ? 3.389   11.614  21.350  1.000 51.380  ? 28  ASP A N     1 ? 
ATOM   218  C  CA    . ASP A 1 28  ? 3.697   12.994  21.813  1.000 53.066  ? 28  ASP A CA    1 ? 
ATOM   219  C  C     . ASP A 1 28  ? 4.762   13.622  20.911  1.000 54.985  ? 28  ASP A C     1 ? 
ATOM   220  O  O     . ASP A 1 28  ? 4.529   14.737  20.433  1.000 60.531  ? 28  ASP A O     1 ? 
ATOM   221  C  CB    . ASP A 1 28  ? 4.139   12.987  23.273  1.000 51.651  ? 28  ASP A CB    1 ? 
ATOM   222  C  CG    . ASP A 1 28  ? 3.035   12.519  24.200  1.000 57.282  ? 28  ASP A CG    1 ? 
ATOM   223  O  OD1   . ASP A 1 28  ? 1.866   12.453  23.735  1.000 55.194  ? 28  ASP A OD1   1 ? 
ATOM   224  O  OD2   . ASP A 1 28  ? 3.343   12.215  25.369  1.000 57.216  ? 28  ASP A OD2   1 ? 
ATOM   225  N  N     . GLU A 1 29  ? 5.877   12.927  20.675  1.000 61.516  ? 29  GLU A N     1 ? 
ATOM   226  C  CA    . GLU A 1 29  ? 6.986   13.432  19.820  1.000 61.930  ? 29  GLU A CA    1 ? 
ATOM   227  C  C     . GLU A 1 29  ? 6.514   13.524  18.367  1.000 58.141  ? 29  GLU A C     1 ? 
ATOM   228  O  O     . GLU A 1 29  ? 7.048   14.385  17.644  1.000 64.131  ? 29  GLU A O     1 ? 
ATOM   229  C  CB    . GLU A 1 29  ? 8.225   12.549  19.948  1.000 63.717  ? 29  GLU A CB    1 ? 
ATOM   230  C  CG    . GLU A 1 29  ? 8.954   12.733  21.261  1.000 65.590  ? 29  GLU A CG    1 ? 
ATOM   231  C  CD    . GLU A 1 29  ? 9.737   11.513  21.714  1.000 66.812  ? 29  GLU A CD    1 ? 
ATOM   232  O  OE1   . GLU A 1 29  ? 10.436  10.897  20.869  1.000 62.674  ? 29  GLU A OE1   1 ? 
ATOM   233  O  OE2   . GLU A 1 29  ? 9.630   11.168  22.906  1.000 69.593  ? 29  GLU A OE2   1 ? 
ATOM   234  N  N     . ARG A 1 30  ? 5.554   12.682  17.957  1.000 55.198  ? 30  ARG A N     1 ? 
ATOM   235  C  CA    . ARG A 1 30  ? 4.876   12.796  16.631  1.000 54.266  ? 30  ARG A CA    1 ? 
ATOM   236  C  C     . ARG A 1 30  ? 3.957   14.026  16.628  1.000 53.360  ? 30  ARG A C     1 ? 
ATOM   237  O  O     . ARG A 1 30  ? 4.012   14.801  15.657  1.000 49.457  ? 30  ARG A O     1 ? 
ATOM   238  C  CB    . ARG A 1 30  ? 4.025   11.567  16.290  1.000 50.927  ? 30  ARG A CB    1 ? 
ATOM   239  C  CG    . ARG A 1 30  ? 3.144   11.776  15.060  1.000 46.937  ? 30  ARG A CG    1 ? 
ATOM   240  C  CD    . ARG A 1 30  ? 2.052   10.740  14.857  1.000 47.687  ? 30  ARG A CD    1 ? 
ATOM   241  N  NE    . ARG A 1 30  ? 0.991   10.843  15.857  1.000 49.428  ? 30  ARG A NE    1 ? 
ATOM   242  C  CZ    . ARG A 1 30  ? 0.550   9.842   16.621  1.000 47.811  ? 30  ARG A CZ    1 ? 
ATOM   243  N  NH1   . ARG A 1 30  ? 1.059   8.623   16.506  1.000 47.353  ? 30  ARG A NH1   1 ? 
ATOM   244  N  NH2   . ARG A 1 30  ? -0.413  10.065  17.495  1.000 49.585  ? 30  ARG A NH2   1 ? 
ATOM   245  N  N     . ASP A 1 31  ? 3.086   14.136  17.638  1.000 56.701  ? 31  ASP A N     1 ? 
ATOM   246  C  CA    . ASP A 1 31  ? 2.129   15.262  17.811  1.000 55.434  ? 31  ASP A CA    1 ? 
ATOM   247  C  C     . ASP A 1 31  ? 2.919   16.570  17.937  1.000 61.015  ? 31  ASP A C     1 ? 
ATOM   248  O  O     . ASP A 1 31  ? 2.545   17.557  17.262  1.000 70.925  ? 31  ASP A O     1 ? 
ATOM   249  C  CB    . ASP A 1 31  ? 1.225   15.035  19.022  1.000 50.784  ? 31  ASP A CB    1 ? 
ATOM   250  C  CG    . ASP A 1 31  ? 0.201   13.943  18.809  1.000 46.745  ? 31  ASP A CG    1 ? 
ATOM   251  O  OD1   . ASP A 1 31  ? -0.161  13.705  17.654  1.000 39.849  ? 31  ASP A OD1   1 ? 
ATOM   252  O  OD2   . ASP A 1 31  ? -0.219  13.339  19.810  1.000 54.682  ? 31  ASP A OD2   1 ? 
ATOM   253  N  N     . ALA A 1 32  ? 4.006   16.555  18.719  1.000 57.730  ? 32  ALA A N     1 ? 
ATOM   254  C  CA    . ALA A 1 32  ? 4.908   17.710  18.938  1.000 56.661  ? 32  ALA A CA    1 ? 
ATOM   255  C  C     . ALA A 1 32  ? 5.363   18.297  17.592  1.000 53.195  ? 32  ALA A C     1 ? 
ATOM   256  O  O     . ALA A 1 32  ? 5.721   19.481  17.569  1.000 53.203  ? 32  ALA A O     1 ? 
ATOM   257  C  CB    . ALA A 1 32  ? 6.086   17.301  19.793  1.000 56.715  ? 32  ALA A CB    1 ? 
ATOM   258  N  N     . VAL A 1 33  ? 5.357   17.506  16.514  1.000 51.546  ? 33  VAL A N     1 ? 
ATOM   259  C  CA    . VAL A 1 33  ? 5.909   17.928  15.192  1.000 53.469  ? 33  VAL A CA    1 ? 
ATOM   260  C  C     . VAL A 1 33  ? 4.756   18.362  14.282  1.000 54.441  ? 33  VAL A C     1 ? 
ATOM   261  O  O     . VAL A 1 33  ? 4.982   19.252  13.458  1.000 53.555  ? 33  VAL A O     1 ? 
ATOM   262  C  CB    . VAL A 1 33  ? 6.768   16.819  14.550  1.000 51.852  ? 33  VAL A CB    1 ? 
ATOM   263  C  CG1   . VAL A 1 33  ? 7.290   17.207  13.176  1.000 48.730  ? 33  VAL A CG1   1 ? 
ATOM   264  C  CG2   . VAL A 1 33  ? 7.924   16.420  15.448  1.000 52.645  ? 33  VAL A CG2   1 ? 
ATOM   265  N  N     . LEU A 1 34  ? 3.578   17.743  14.410  1.000 55.943  ? 34  LEU A N     1 ? 
ATOM   266  C  CA    . LEU A 1 34  ? 2.373   18.096  13.607  1.000 61.259  ? 34  LEU A CA    1 ? 
ATOM   267  C  C     . LEU A 1 34  ? 1.847   19.457  14.081  1.000 63.866  ? 34  LEU A C     1 ? 
ATOM   268  O  O     . LEU A 1 34  ? 1.586   20.323  13.226  1.000 64.281  ? 34  LEU A O     1 ? 
ATOM   269  C  CB    . LEU A 1 34  ? 1.295   17.013  13.767  1.000 61.228  ? 34  LEU A CB    1 ? 
ATOM   270  C  CG    . LEU A 1 34  ? 1.571   15.657  13.112  1.000 57.309  ? 34  LEU A CG    1 ? 
ATOM   271  C  CD1   . LEU A 1 34  ? 0.395   14.710  13.337  1.000 58.491  ? 34  LEU A CD1   1 ? 
ATOM   272  C  CD2   . LEU A 1 34  ? 1.858   15.796  11.624  1.000 54.607  ? 34  LEU A CD2   1 ? 
ATOM   273  N  N     . THR A 1 35  ? 1.681   19.606  15.399  1.000 61.177  ? 35  THR A N     1 ? 
ATOM   274  C  CA    . THR A 1 35  ? 1.338   20.871  16.097  1.000 64.281  ? 35  THR A CA    1 ? 
ATOM   275  C  C     . THR A 1 35  ? 2.313   21.961  15.637  1.000 66.277  ? 35  THR A C     1 ? 
ATOM   276  O  O     . THR A 1 35  ? 1.863   23.081  15.399  1.000 66.315  ? 35  THR A O     1 ? 
ATOM   277  C  CB    . THR A 1 35  ? 1.355   20.657  17.618  1.000 69.570  ? 35  THR A CB    1 ? 
ATOM   278  O  OG1   . THR A 1 35  ? 0.297   19.750  17.931  1.000 72.178  ? 35  THR A OG1   1 ? 
ATOM   279  C  CG2   . THR A 1 35  ? 1.186   21.930  18.420  1.000 71.008  ? 35  THR A CG2   1 ? 
ATOM   280  N  N     . ALA A 1 36  ? 3.592   21.609  15.484  1.000 69.557  ? 36  ALA A N     1 ? 
ATOM   281  C  CA    . ALA A 1 36  ? 4.699   22.515  15.092  1.000 68.149  ? 36  ALA A CA    1 ? 
ATOM   282  C  C     . ALA A 1 36  ? 4.596   22.888  13.608  1.000 64.149  ? 36  ALA A C     1 ? 
ATOM   283  O  O     . ALA A 1 36  ? 4.963   24.024  13.277  1.000 68.347  ? 36  ALA A O     1 ? 
ATOM   284  C  CB    . ALA A 1 36  ? 6.030   21.871  15.402  1.000 65.353  ? 36  ALA A CB    1 ? 
ATOM   285  N  N     . VAL A 1 37  ? 4.149   21.961  12.755  1.000 65.279  ? 37  VAL A N     1 ? 
ATOM   286  C  CA    . VAL A 1 37  ? 3.913   22.199  11.297  1.000 69.417  ? 37  VAL A CA    1 ? 
ATOM   287  C  C     . VAL A 1 37  ? 2.803   23.251  11.158  1.000 76.574  ? 37  VAL A C     1 ? 
ATOM   288  O  O     . VAL A 1 37  ? 3.099   24.347  10.653  1.000 80.207  ? 37  VAL A O     1 ? 
ATOM   289  C  CB    . VAL A 1 37  ? 3.567   20.899  10.536  1.000 64.200  ? 37  VAL A CB    1 ? 
ATOM   290  C  CG1   . VAL A 1 37  ? 2.814   21.166  9.238   1.000 65.779  ? 37  VAL A CG1   1 ? 
ATOM   291  C  CG2   . VAL A 1 37  ? 4.804   20.059  10.253  1.000 62.421  ? 37  VAL A CG2   1 ? 
ATOM   292  N  N     . ARG A 1 38  ? 1.582   22.938  11.610  1.000 83.295  ? 38  ARG A N     1 ? 
ATOM   293  C  CA    . ARG A 1 38  ? 0.397   23.835  11.466  1.000 86.930  ? 38  ARG A CA    1 ? 
ATOM   294  C  C     . ARG A 1 38  ? 0.790   25.246  11.947  1.000 85.725  ? 38  ARG A C     1 ? 
ATOM   295  O  O     . ARG A 1 38  ? 0.618   26.197  11.159  1.000 86.957  ? 38  ARG A O     1 ? 
ATOM   296  C  CB    . ARG A 1 38  ? -0.849  23.252  12.160  1.000 88.336  ? 38  ARG A CB    1 ? 
ATOM   297  C  CG    . ARG A 1 38  ? -0.690  22.890  13.633  1.000 91.570  ? 38  ARG A CG    1 ? 
ATOM   298  C  CD    . ARG A 1 38  ? -2.022  22.581  14.298  1.000 91.505  ? 38  ARG A CD    1 ? 
ATOM   299  N  NE    . ARG A 1 38  ? -2.693  21.401  13.751  1.000 98.166  ? 38  ARG A NE    1 ? 
ATOM   300  C  CZ    . ARG A 1 38  ? -3.970  21.062  13.989  1.000 102.671 ? 38  ARG A CZ    1 ? 
ATOM   301  N  NH1   . ARG A 1 38  ? -4.478  19.968  13.442  1.000 96.997  ? 38  ARG A NH1   1 ? 
ATOM   302  N  NH2   . ARG A 1 38  ? -4.736  21.815  14.765  1.000 99.490  ? 38  ARG A NH2   1 ? 
ATOM   303  N  N     . GLU A 1 39  ? 1.390   25.357  13.140  1.000 78.275  ? 39  GLU A N     1 ? 
ATOM   304  C  CA    . GLU A 1 39  ? 1.896   26.629  13.730  1.000 73.297  ? 39  GLU A CA    1 ? 
ATOM   305  C  C     . GLU A 1 39  ? 2.928   27.262  12.794  1.000 67.207  ? 39  GLU A C     1 ? 
ATOM   306  O  O     . GLU A 1 39  ? 2.891   28.484  12.618  1.000 71.639  ? 39  GLU A O     1 ? 
ATOM   307  C  CB    . GLU A 1 39  ? 2.560   26.380  15.085  1.000 74.405  ? 39  GLU A CB    1 ? 
ATOM   308  C  CG    . GLU A 1 39  ? 1.598   25.921  16.159  1.000 73.598  ? 39  GLU A CG    1 ? 
ATOM   309  C  CD    . GLU A 1 39  ? 0.819   27.023  16.845  1.000 80.425  ? 39  GLU A CD    1 ? 
ATOM   310  O  OE1   . GLU A 1 39  ? 0.586   28.078  16.211  1.000 86.936  ? 39  GLU A OE1   1 ? 
ATOM   311  O  OE2   . GLU A 1 39  ? 0.436   26.818  18.009  1.000 87.320  ? 39  GLU A OE2   1 ? 
ATOM   312  N  N     . GLY A 1 40  ? 3.849   26.454  12.273  1.000 60.158  ? 40  GLY A N     1 ? 
ATOM   313  C  CA    . GLY A 1 40  ? 4.881   26.888  11.316  1.000 56.432  ? 40  GLY A CA    1 ? 
ATOM   314  C  C     . GLY A 1 40  ? 4.289   27.229  9.962   1.000 54.082  ? 40  GLY A C     1 ? 
ATOM   315  O  O     . GLY A 1 40  ? 4.934   27.979  9.236   1.000 54.646  ? 40  GLY A O     1 ? 
ATOM   316  N  N     . LEU A 1 41  ? 3.118   26.680  9.628   1.000 57.438  ? 41  LEU A N     1 ? 
ATOM   317  C  CA    . LEU A 1 41  ? 2.440   26.898  8.321   1.000 64.749  ? 41  LEU A CA    1 ? 
ATOM   318  C  C     . LEU A 1 41  ? 1.731   28.260  8.314   1.000 70.440  ? 41  LEU A C     1 ? 
ATOM   319  O  O     . LEU A 1 41  ? 1.411   28.751  7.192   1.000 67.323  ? 41  LEU A O     1 ? 
ATOM   320  C  CB    . LEU A 1 41  ? 1.437   25.772  8.056   1.000 66.447  ? 41  LEU A CB    1 ? 
ATOM   321  C  CG    . LEU A 1 41  ? 2.021   24.472  7.510   1.000 68.883  ? 41  LEU A CG    1 ? 
ATOM   322  C  CD1   . LEU A 1 41  ? 0.909   23.591  6.960   1.000 71.573  ? 41  LEU A CD1   1 ? 
ATOM   323  C  CD2   . LEU A 1 41  ? 3.073   24.736  6.440   1.000 67.306  ? 41  LEU A CD2   1 ? 
ATOM   324  N  N     . LYS A 1 42  ? 1.451   28.816  9.504   1.000 63.843  ? 42  LYS A N     1 ? 
ATOM   325  C  CA    . LYS A 1 42  ? 0.892   30.188  9.685   1.000 67.551  ? 42  LYS A CA    1 ? 
ATOM   326  C  C     . LYS A 1 42  ? 2.004   31.211  9.434   1.000 69.364  ? 42  LYS A C     1 ? 
ATOM   327  O  O     . LYS A 1 42  ? 1.726   32.270  8.831   1.000 76.150  ? 42  LYS A O     1 ? 
ATOM   328  C  CB    . LYS A 1 42  ? 0.352   30.400  11.106  1.000 61.864  ? 42  LYS A CB    1 ? 
ATOM   329  C  CG    . LYS A 1 42  ? -0.751  29.450  11.552  1.000 58.748  ? 42  LYS A CG    1 ? 
ATOM   330  C  CD    . LYS A 1 42  ? -1.015  29.512  13.038  1.000 58.969  ? 42  LYS A CD    1 ? 
ATOM   331  C  CE    . LYS A 1 42  ? -1.749  28.293  13.558  1.000 63.130  ? 42  LYS A CE    1 ? 
ATOM   332  N  NZ    . LYS A 1 42  ? -2.059  28.402  15.006  1.000 63.088  ? 42  LYS A NZ    1 ? 
ATOM   333  N  N     . LYS A 1 43  ? 3.213   30.880  9.889   1.000 67.695  ? 43  LYS A N     1 ? 
ATOM   334  C  CA    . LYS A 1 43  ? 4.423   31.741  9.862   1.000 63.683  ? 43  LYS A CA    1 ? 
ATOM   335  C  C     . LYS A 1 43  ? 5.020   31.768  8.446   1.000 62.729  ? 43  LYS A C     1 ? 
ATOM   336  O  O     . LYS A 1 43  ? 6.020   32.491  8.253   1.000 60.458  ? 43  LYS A O     1 ? 
ATOM   337  C  CB    . LYS A 1 43  ? 5.437   31.203  10.877  1.000 64.559  ? 43  LYS A CB    1 ? 
ATOM   338  C  CG    . LYS A 1 43  ? 6.101   32.245  11.763  1.000 66.464  ? 43  LYS A CG    1 ? 
ATOM   339  C  CD    . LYS A 1 43  ? 7.014   31.636  12.811  1.000 69.088  ? 43  LYS A CD    1 ? 
ATOM   340  C  CE    . LYS A 1 43  ? 7.207   32.522  14.027  1.000 74.325  ? 43  LYS A CE    1 ? 
ATOM   341  N  NZ    . LYS A 1 43  ? 7.970   33.756  13.709  1.000 73.513  ? 43  LYS A NZ    1 ? 
ATOM   342  N  N     . VAL A 1 44  ? 4.448   31.004  7.506   1.000 57.334  ? 44  VAL A N     1 ? 
ATOM   343  C  CA    . VAL A 1 44  ? 4.950   30.869  6.107   1.000 64.552  ? 44  VAL A CA    1 ? 
ATOM   344  C  C     . VAL A 1 44  ? 3.831   31.289  5.150   1.000 67.133  ? 44  VAL A C     1 ? 
ATOM   345  O  O     . VAL A 1 44  ? 4.072   32.197  4.352   1.000 62.939  ? 44  VAL A O     1 ? 
ATOM   346  C  CB    . VAL A 1 44  ? 5.454   29.438  5.810   1.000 68.589  ? 44  VAL A CB    1 ? 
ATOM   347  C  CG1   . VAL A 1 44  ? 5.680   29.201  4.322   1.000 69.210  ? 44  VAL A CG1   1 ? 
ATOM   348  C  CG2   . VAL A 1 44  ? 6.722   29.111  6.587   1.000 67.138  ? 44  VAL A CG2   1 ? 
ATOM   349  N  N     . PHE A 1 45  ? 2.660   30.642  5.235   1.000 78.649  ? 45  PHE A N     1 ? 
ATOM   350  C  CA    . PHE A 1 45  ? 1.476   30.897  4.365   1.000 84.399  ? 45  PHE A CA    1 ? 
ATOM   351  C  C     . PHE A 1 45  ? 0.622   32.028  4.968   1.000 90.135  ? 45  PHE A C     1 ? 
ATOM   352  O  O     . PHE A 1 45  ? -0.630  31.920  4.989   1.000 91.123  ? 45  PHE A O     1 ? 
ATOM   353  C  CB    . PHE A 1 45  ? 0.671   29.610  4.152   1.000 84.785  ? 45  PHE A CB    1 ? 
ATOM   354  C  CG    . PHE A 1 45  ? 0.730   29.042  2.755   1.000 81.307  ? 45  PHE A CG    1 ? 
ATOM   355  C  CD1   . PHE A 1 45  ? 1.771   28.213  2.365   1.000 79.790  ? 45  PHE A CD1   1 ? 
ATOM   356  C  CD2   . PHE A 1 45  ? -0.279  29.308  1.837   1.000 81.206  ? 45  PHE A CD2   1 ? 
ATOM   357  C  CE1   . PHE A 1 45  ? 1.810   27.675  1.085   1.000 75.108  ? 45  PHE A CE1   1 ? 
ATOM   358  C  CE2   . PHE A 1 45  ? -0.240  28.771  0.557   1.000 76.832  ? 45  PHE A CE2   1 ? 
ATOM   359  C  CZ    . PHE A 1 45  ? 0.808   27.960  0.182   1.000 78.335  ? 45  PHE A CZ    1 ? 
ATOM   360  N  N     . ALA A 1 46  ? 1.295   33.071  5.465   1.000 86.535  ? 46  ALA A N     1 ? 
ATOM   361  C  CA    . ALA A 1 46  ? 0.728   34.399  5.789   1.000 81.611  ? 46  ALA A CA    1 ? 
ATOM   362  C  C     . ALA A 1 46  ? 1.513   35.452  5.009   1.000 79.872  ? 46  ALA A C     1 ? 
ATOM   363  O  O     . ALA A 1 46  ? 0.878   36.339  4.415   1.000 88.336  ? 46  ALA A O     1 ? 
ATOM   364  C  CB    . ALA A 1 46  ? 0.789   34.650  7.276   1.000 83.056  ? 46  ALA A CB    1 ? 
ATOM   365  N  N     . ASP A 1 47  ? 2.844   35.335  5.022   1.000 78.777  ? 47  ASP A N     1 ? 
ATOM   366  C  CA    . ASP A 1 47  ? 3.786   36.103  4.160   1.000 79.034  ? 47  ASP A CA    1 ? 
ATOM   367  C  C     . ASP A 1 47  ? 3.269   36.118  2.719   1.000 72.568  ? 47  ASP A C     1 ? 
ATOM   368  O  O     . ASP A 1 47  ? 3.165   37.211  2.140   1.000 78.791  ? 47  ASP A O     1 ? 
ATOM   369  C  CB    . ASP A 1 47  ? 5.192   35.496  4.183   1.000 81.090  ? 47  ASP A CB    1 ? 
ATOM   370  C  CG    . ASP A 1 47  ? 5.709   35.194  5.579   1.000 79.791  ? 47  ASP A CG    1 ? 
ATOM   371  O  OD1   . ASP A 1 47  ? 4.902   35.289  6.541   1.000 71.243  ? 47  ASP A OD1   1 ? 
ATOM   372  O  OD2   . ASP A 1 47  ? 6.908   34.857  5.694   1.000 77.537  ? 47  ASP A OD2   1 ? 
ATOM   373  N  N     . ARG A 1 48  ? 2.968   34.937  2.178   1.000 69.866  ? 48  ARG A N     1 ? 
ATOM   374  C  CA    . ARG A 1 48  ? 2.544   34.714  0.769   1.000 67.727  ? 48  ARG A CA    1 ? 
ATOM   375  C  C     . ARG A 1 48  ? 1.478   35.724  0.356   1.000 63.876  ? 48  ARG A C     1 ? 
ATOM   376  O  O     . ARG A 1 48  ? 1.644   36.349  -0.703  1.000 75.470  ? 48  ARG A O     1 ? 
ATOM   377  C  CB    . ARG A 1 48  ? 1.952   33.316  0.607   1.000 67.240  ? 48  ARG A CB    1 ? 
ATOM   378  C  CG    . ARG A 1 48  ? 2.957   32.202  0.832   1.000 75.053  ? 48  ARG A CG    1 ? 
ATOM   379  C  CD    . ARG A 1 48  ? 2.309   30.855  0.656   1.000 79.243  ? 48  ARG A CD    1 ? 
ATOM   380  N  NE    . ARG A 1 48  ? 1.855   30.645  -0.715  1.000 82.940  ? 48  ARG A NE    1 ? 
ATOM   381  C  CZ    . ARG A 1 48  ? 2.611   30.189  -1.713  1.000 80.562  ? 48  ARG A CZ    1 ? 
ATOM   382  N  NH1   . ARG A 1 48  ? 2.089   30.053  -2.920  1.000 82.549  ? 48  ARG A NH1   1 ? 
ATOM   383  N  NH2   . ARG A 1 48  ? 3.878   29.872  -1.511  1.000 80.793  ? 48  ARG A NH2   1 ? 
ATOM   384  N  N     . GLY A 1 49  ? 0.415   35.840  1.153   1.000 62.608  ? 49  GLY A N     1 ? 
ATOM   385  C  CA    . GLY A 1 49  ? -0.827  36.545  0.785   1.000 59.561  ? 49  GLY A CA    1 ? 
ATOM   386  C  C     . GLY A 1 49  ? -2.016  35.600  0.717   1.000 58.460  ? 49  GLY A C     1 ? 
ATOM   387  O  O     . GLY A 1 49  ? -3.152  36.085  0.923   1.000 58.300  ? 49  GLY A O     1 ? 
ATOM   388  N  N     . GLU A 1 50  ? -1.768  34.297  0.472   1.000 55.552  ? 50  GLU A N     1 ? 
ATOM   389  C  CA    . GLU A 1 50  ? -2.806  33.220  0.407   1.000 49.802  ? 50  GLU A CA    1 ? 
ATOM   390  C  C     . GLU A 1 50  ? -2.978  32.532  1.770   1.000 45.894  ? 50  GLU A C     1 ? 
ATOM   391  O  O     . GLU A 1 50  ? -2.094  32.650  2.640   1.000 38.572  ? 50  GLU A O     1 ? 
ATOM   392  C  CB    . GLU A 1 50  ? -2.454  32.164  -0.643  1.000 50.264  ? 50  GLU A CB    1 ? 
ATOM   393  C  CG    . GLU A 1 50  ? -2.732  32.598  -2.073  1.000 49.976  ? 50  GLU A CG    1 ? 
ATOM   394  C  CD    . GLU A 1 50  ? -1.655  33.477  -2.675  1.000 45.310  ? 50  GLU A CD    1 ? 
ATOM   395  O  OE1   . GLU A 1 50  ? -1.982  34.295  -3.542  1.000 42.628  ? 50  GLU A OE1   1 ? 
ATOM   396  O  OE2   . GLU A 1 50  ? -0.493  33.334  -2.265  1.000 49.992  ? 50  GLU A OE2   1 ? 
ATOM   397  N  N     . ALA A 1 51  ? -4.084  31.809  1.919   1.000 51.067  ? 51  ALA A N     1 ? 
ATOM   398  C  CA    . ALA A 1 51  ? -4.468  31.086  3.150   1.000 60.650  ? 51  ALA A CA    1 ? 
ATOM   399  C  C     . ALA A 1 51  ? -3.604  29.820  3.295   1.000 67.560  ? 51  ALA A C     1 ? 
ATOM   400  O  O     . ALA A 1 51  ? -3.158  29.261  2.247   1.000 59.340  ? 51  ALA A O     1 ? 
ATOM   401  C  CB    . ALA A 1 51  ? -5.947  30.766  3.104   1.000 64.074  ? 51  ALA A CB    1 ? 
ATOM   402  N  N     . ALA A 1 52  ? -3.370  29.388  4.544   1.000 68.376  ? 52  ALA A N     1 ? 
ATOM   403  C  CA    . ALA A 1 52  ? -2.612  28.165  4.911   1.000 68.536  ? 52  ALA A CA    1 ? 
ATOM   404  C  C     . ALA A 1 52  ? -3.179  26.945  4.183   1.000 71.387  ? 52  ALA A C     1 ? 
ATOM   405  O  O     . ALA A 1 52  ? -4.396  26.804  4.048   1.000 65.056  ? 52  ALA A O     1 ? 
ATOM   406  C  CB    . ALA A 1 52  ? -2.658  27.965  6.402   1.000 65.600  ? 52  ALA A CB    1 ? 
ATOM   407  N  N     . PRO A 1 53  ? -2.318  26.023  3.688   1.000 74.545  ? 53  PRO A N     1 ? 
ATOM   408  C  CA    . PRO A 1 53  ? -2.768  24.699  3.268   1.000 70.815  ? 53  PRO A CA    1 ? 
ATOM   409  C  C     . PRO A 1 53  ? -3.000  23.809  4.497   1.000 66.803  ? 53  PRO A C     1 ? 
ATOM   410  O  O     . PRO A 1 53  ? -2.212  23.869  5.457   1.000 56.104  ? 53  PRO A O     1 ? 
ATOM   411  C  CB    . PRO A 1 53  ? -1.620  24.195  2.392   1.000 74.311  ? 53  PRO A CB    1 ? 
ATOM   412  C  CG    . PRO A 1 53  ? -0.394  24.848  3.003   1.000 74.021  ? 53  PRO A CG    1 ? 
ATOM   413  C  CD    . PRO A 1 53  ? -0.873  26.200  3.497   1.000 76.555  ? 53  PRO A CD    1 ? 
ATOM   414  N  N     . THR A 1 54  ? -4.107  23.064  4.467   1.000 68.028  ? 54  THR A N     1 ? 
ATOM   415  C  CA    . THR A 1 54  ? -4.549  22.125  5.531   1.000 64.804  ? 54  THR A CA    1 ? 
ATOM   416  C  C     . THR A 1 54  ? -4.177  20.699  5.103   1.000 62.433  ? 54  THR A C     1 ? 
ATOM   417  O  O     . THR A 1 54  ? -4.220  20.400  3.869   1.000 63.150  ? 54  THR A O     1 ? 
ATOM   418  C  CB    . THR A 1 54  ? -6.046  22.308  5.820   1.000 61.389  ? 54  THR A CB    1 ? 
ATOM   419  O  OG1   . THR A 1 54  ? -6.765  22.190  4.589   1.000 61.653  ? 54  THR A OG1   1 ? 
ATOM   420  C  CG2   . THR A 1 54  ? -6.350  23.643  6.463   1.000 57.650  ? 54  THR A CG2   1 ? 
ATOM   421  N  N     . PHE A 1 55  ? -3.806  19.857  6.068   1.000 54.678  ? 55  PHE A N     1 ? 
ATOM   422  C  CA    . PHE A 1 55  ? -3.272  18.499  5.816   1.000 47.763  ? 55  PHE A CA    1 ? 
ATOM   423  C  C     . PHE A 1 55  ? -3.868  17.503  6.796   1.000 40.196  ? 55  PHE A C     1 ? 
ATOM   424  O  O     . PHE A 1 55  ? -4.018  17.823  7.995   1.000 34.646  ? 55  PHE A O     1 ? 
ATOM   425  C  CB    . PHE A 1 55  ? -1.756  18.469  5.989   1.000 49.057  ? 55  PHE A CB    1 ? 
ATOM   426  C  CG    . PHE A 1 55  ? -1.315  18.812  7.383   1.000 45.783  ? 55  PHE A CG    1 ? 
ATOM   427  C  CD1   . PHE A 1 55  ? -1.035  17.816  8.306   1.000 42.666  ? 55  PHE A CD1   1 ? 
ATOM   428  C  CD2   . PHE A 1 55  ? -1.213  20.137  7.781   1.000 45.307  ? 55  PHE A CD2   1 ? 
ATOM   429  C  CE1   . PHE A 1 55  ? -0.650  18.147  9.595   1.000 44.960  ? 55  PHE A CE1   1 ? 
ATOM   430  C  CE2   . PHE A 1 55  ? -0.819  20.461  9.070   1.000 42.309  ? 55  PHE A CE2   1 ? 
ATOM   431  C  CZ    . PHE A 1 55  ? -0.549  19.468  9.977   1.000 43.805  ? 55  PHE A CZ    1 ? 
ATOM   432  N  N     . THR A 1 56  ? -4.072  16.291  6.294   1.000 37.198  ? 56  THR A N     1 ? 
ATOM   433  C  CA    . THR A 1 56  ? -4.460  15.089  7.057   1.000 34.784  ? 56  THR A CA    1 ? 
ATOM   434  C  C     . THR A 1 56  ? -3.200  14.288  7.356   1.000 33.889  ? 56  THR A C     1 ? 
ATOM   435  O  O     . THR A 1 56  ? -2.567  13.771  6.431   1.000 35.189  ? 56  THR A O     1 ? 
ATOM   436  C  CB    . THR A 1 56  ? -5.482  14.295  6.245   1.000 36.305  ? 56  THR A CB    1 ? 
ATOM   437  O  OG1   . THR A 1 56  ? -6.538  15.220  5.999   1.000 37.843  ? 56  THR A OG1   1 ? 
ATOM   438  C  CG2   . THR A 1 56  ? -6.000  13.053  6.940   1.000 38.318  ? 56  THR A CG2   1 ? 
ATOM   439  N  N     . PRO A 1 57  ? -2.779  14.181  8.637   1.000 29.168  ? 57  PRO A N     1 ? 
ATOM   440  C  CA    . PRO A 1 57  ? -1.702  13.279  9.014   1.000 31.165  ? 57  PRO A CA    1 ? 
ATOM   441  C  C     . PRO A 1 57  ? -2.179  11.827  9.174   1.000 32.447  ? 57  PRO A C     1 ? 
ATOM   442  O  O     . PRO A 1 57  ? -3.370  11.606  9.425   1.000 32.530  ? 57  PRO A O     1 ? 
ATOM   443  C  CB    . PRO A 1 57  ? -1.278  13.819  10.377  1.000 30.251  ? 57  PRO A CB    1 ? 
ATOM   444  C  CG    . PRO A 1 57  ? -2.572  14.287  10.964  1.000 30.476  ? 57  PRO A CG    1 ? 
ATOM   445  C  CD    . PRO A 1 57  ? -3.344  14.871  9.795   1.000 29.874  ? 57  PRO A CD    1 ? 
ATOM   446  N  N     . PHE A 1 58  ? -1.241  10.889  9.106   1.000 27.637  ? 58  PHE A N     1 ? 
ATOM   447  C  CA    . PHE A 1 58  ? -1.455  9.460   9.433   1.000 27.915  ? 58  PHE A CA    1 ? 
ATOM   448  C  C     . PHE A 1 58  ? -0.113  8.815   9.805   1.000 29.015  ? 58  PHE A C     1 ? 
ATOM   449  O  O     . PHE A 1 58  ? 0.954   9.311   9.350   1.000 27.816  ? 58  PHE A O     1 ? 
ATOM   450  C  CB    . PHE A 1 58  ? -2.154  8.762   8.265   1.000 25.572  ? 58  PHE A CB    1 ? 
ATOM   451  C  CG    . PHE A 1 58  ? -1.370  8.685   6.984   1.000 24.360  ? 58  PHE A CG    1 ? 
ATOM   452  C  CD1   . PHE A 1 58  ? -1.435  9.702   6.060   1.000 25.372  ? 58  PHE A CD1   1 ? 
ATOM   453  C  CD2   . PHE A 1 58  ? -0.611  7.565   6.680   1.000 24.923  ? 58  PHE A CD2   1 ? 
ATOM   454  C  CE1   . PHE A 1 58  ? -0.737  9.624   4.860   1.000 25.979  ? 58  PHE A CE1   1 ? 
ATOM   455  C  CE2   . PHE A 1 58  ? 0.092   7.490   5.486   1.000 26.309  ? 58  PHE A CE2   1 ? 
ATOM   456  C  CZ    . PHE A 1 58  ? 0.032   8.529   4.578   1.000 25.677  ? 58  PHE A CZ    1 ? 
ATOM   457  N  N     . ASN A 1 59  ? -0.165  7.726   10.574  1.000 27.385  ? 59  ASN A N     1 ? 
ATOM   458  C  CA    . ASN A 1 59  ? 1.040   6.960   11.004  1.000 30.982  ? 59  ASN A CA    1 ? 
ATOM   459  C  C     . ASN A 1 59  ? 1.606   6.145   9.836   1.000 26.674  ? 59  ASN A C     1 ? 
ATOM   460  O  O     . ASN A 1 59  ? 0.832   5.616   9.064   1.000 31.753  ? 59  ASN A O     1 ? 
ATOM   461  C  CB    . ASN A 1 59  ? 0.726   6.032   12.169  1.000 31.563  ? 59  ASN A CB    1 ? 
ATOM   462  C  CG    . ASN A 1 59  ? 0.256   6.779   13.392  1.000 31.281  ? 59  ASN A CG    1 ? 
ATOM   463  O  OD1   . ASN A 1 59  ? 0.634   7.924   13.611  1.000 34.878  ? 59  ASN A OD1   1 ? 
ATOM   464  N  ND2   . ASN A 1 59  ? -0.558  6.130   14.195  1.000 31.511  ? 59  ASN A ND2   1 ? 
ATOM   465  N  N     . GLN A 1 60  ? 2.926   6.029   9.744   1.000 26.417  ? 60  GLN A N     1 ? 
ATOM   466  C  CA    . GLN A 1 60  ? 3.616   5.242   8.685   1.000 24.242  ? 60  GLN A CA    1 ? 
ATOM   467  C  C     . GLN A 1 60  ? 4.709   4.361   9.292   1.000 22.706  ? 60  GLN A C     1 ? 
ATOM   468  O  O     . GLN A 1 60  ? 5.030   4.531   10.478  1.000 20.370  ? 60  GLN A O     1 ? 
ATOM   469  C  CB    . GLN A 1 60  ? 4.270   6.176   7.681   1.000 26.385  ? 60  GLN A CB    1 ? 
ATOM   470  C  CG    . GLN A 1 60  ? 3.478   6.348   6.406   1.000 28.763  ? 60  GLN A CG    1 ? 
ATOM   471  C  CD    . GLN A 1 60  ? 4.289   7.106   5.394   1.000 30.786  ? 60  GLN A CD    1 ? 
ATOM   472  O  OE1   . GLN A 1 60  ? 3.901   7.239   4.241   1.000 34.126  ? 60  GLN A OE1   1 ? 
ATOM   473  N  NE2   . GLN A 1 60  ? 5.422   7.637   5.836   1.000 34.377  ? 60  GLN A NE2   1 ? 
ATOM   474  N  N     . GLY A 1 61  ? 5.254   3.444   8.487   1.000 21.886  ? 61  GLY A N     1 ? 
ATOM   475  C  CA    . GLY A 1 61  ? 6.485   2.703   8.806   1.000 21.545  ? 61  GLY A CA    1 ? 
ATOM   476  C  C     . GLY A 1 61  ? 6.344   1.871   10.065  1.000 21.761  ? 61  GLY A C     1 ? 
ATOM   477  O  O     . GLY A 1 61  ? 5.202   1.609   10.485  1.000 20.445  ? 61  GLY A O     1 ? 
ATOM   478  N  N     . SER A 1 62  ? 7.473   1.454   10.634  1.000 22.652  ? 62  SER A N     1 ? 
ATOM   479  C  CA    . SER A 1 62  ? 7.577   0.257   11.514  1.000 22.972  ? 62  SER A CA    1 ? 
ATOM   480  C  C     . SER A 1 62  ? 6.807   0.489   12.807  1.000 22.347  ? 62  SER A C     1 ? 
ATOM   481  O  O     . SER A 1 62  ? 6.204   -0.490  13.312  1.000 18.632  ? 62  SER A O     1 ? 
ATOM   482  C  CB    . SER A 1 62  ? 8.993   -0.084  11.793  1.000 21.351  ? 62  SER A CB    1 ? 
ATOM   483  O  OG    . SER A 1 62  ? 9.661   1.007   12.378  1.000 22.457  ? 62  SER A OG    1 ? 
ATOM   484  N  N     . TYR A 1 63  ? 6.828   1.734   13.291  1.000 21.698  ? 63  TYR A N     1 ? 
ATOM   485  C  CA    . TYR A 1 63  ? 6.105   2.170   14.508  1.000 23.182  ? 63  TYR A CA    1 ? 
ATOM   486  C  C     . TYR A 1 63  ? 4.594   1.991   14.289  1.000 24.024  ? 63  TYR A C     1 ? 
ATOM   487  O  O     . TYR A 1 63  ? 3.912   1.741   15.286  1.000 26.354  ? 63  TYR A O     1 ? 
ATOM   488  C  CB    . TYR A 1 63  ? 6.503   3.611   14.882  1.000 24.180  ? 63  TYR A CB    1 ? 
ATOM   489  C  CG    . TYR A 1 63  ? 7.963   3.810   15.212  1.000 24.605  ? 63  TYR A CG    1 ? 
ATOM   490  C  CD1   . TYR A 1 63  ? 8.819   2.726   15.344  1.000 26.221  ? 63  TYR A CD1   1 ? 
ATOM   491  C  CD2   . TYR A 1 63  ? 8.496   5.076   15.428  1.000 25.416  ? 63  TYR A CD2   1 ? 
ATOM   492  C  CE1   . TYR A 1 63  ? 10.160  2.886   15.663  1.000 26.709  ? 63  TYR A CE1   1 ? 
ATOM   493  C  CE2   . TYR A 1 63  ? 9.840   5.257   15.737  1.000 25.223  ? 63  TYR A CE2   1 ? 
ATOM   494  C  CZ    . TYR A 1 63  ? 10.669  4.153   15.885  1.000 27.145  ? 63  TYR A CZ    1 ? 
ATOM   495  O  OH    . TYR A 1 63  ? 11.986  4.285   16.206  1.000 26.419  ? 63  TYR A OH    1 ? 
ATOM   496  N  N     . ALA A 1 64  ? 4.095   2.087   13.037  1.000 22.497  ? 64  ALA A N     1 ? 
ATOM   497  C  CA    . ALA A 1 64  ? 2.667   1.861   12.679  1.000 22.135  ? 64  ALA A CA    1 ? 
ATOM   498  C  C     . ALA A 1 64  ? 2.379   0.360   12.479  1.000 21.605  ? 64  ALA A C     1 ? 
ATOM   499  O  O     . ALA A 1 64  ? 1.197   -0.078  12.722  1.000 20.541  ? 64  ALA A O     1 ? 
ATOM   500  C  CB    . ALA A 1 64  ? 2.291   2.656   11.441  1.000 22.178  ? 64  ALA A CB    1 ? 
ATOM   501  N  N     . MET A 1 65  ? 3.369   -0.414  12.016  1.000 19.597  ? 65  MET A N     1 ? 
ATOM   502  C  CA    . MET A 1 65  ? 3.161   -1.839  11.647  1.000 19.326  ? 65  MET A CA    1 ? 
ATOM   503  C  C     . MET A 1 65  ? 3.548   -2.781  12.794  1.000 17.546  ? 65  MET A C     1 ? 
ATOM   504  O  O     . MET A 1 65  ? 3.367   -4.011  12.634  1.000 18.198  ? 65  MET A O     1 ? 
ATOM   505  C  CB    . MET A 1 65  ? 3.956   -2.181  10.392  1.000 19.929  ? 65  MET A CB    1 ? 
ATOM   506  C  CG    . MET A 1 65  ? 3.474   -1.419  9.194   1.000 21.646  ? 65  MET A CG    1 ? 
ATOM   507  S  SD    . MET A 1 65  ? 4.438   -1.877  7.767   1.000 21.661  ? 65  MET A SD    1 ? 
ATOM   508  C  CE    . MET A 1 65  ? 5.797   -0.729  7.975   1.000 22.847  ? 65  MET A CE    1 ? 
ATOM   509  N  N     . ASN A 1 66  ? 4.031   -2.259  13.908  1.000 17.518  ? 66  ASN A N     1 ? 
ATOM   510  C  CA    . ASN A 1 66  ? 4.447   -3.096  15.072  1.000 16.874  ? 66  ASN A CA    1 ? 
ATOM   511  C  C     . ASN A 1 66  ? 5.665   -3.971  14.716  1.000 16.775  ? 66  ASN A C     1 ? 
ATOM   512  O  O     . ASN A 1 66  ? 5.714   -5.150  15.156  1.000 16.876  ? 66  ASN A O     1 ? 
ATOM   513  C  CB    . ASN A 1 66  ? 3.306   -3.984  15.538  1.000 17.758  ? 66  ASN A CB    1 ? 
ATOM   514  C  CG    . ASN A 1 66  ? 3.549   -4.484  16.940  1.000 18.427  ? 66  ASN A CG    1 ? 
ATOM   515  O  OD1   . ASN A 1 66  ? 4.287   -3.841  17.690  1.000 19.883  ? 66  ASN A OD1   1 ? 
ATOM   516  N  ND2   . ASN A 1 66  ? 2.937   -5.607  17.296  1.000 15.682  ? 66  ASN A ND2   1 ? 
ATOM   517  N  N     . THR A 1 67  ? 6.622   -3.394  13.985  1.000 16.398  ? 67  THR A N     1 ? 
ATOM   518  C  CA    . THR A 1 67  ? 7.909   -3.991  13.571  1.000 16.534  ? 67  THR A CA    1 ? 
ATOM   519  C  C     . THR A 1 67  ? 9.059   -3.062  13.977  1.000 17.992  ? 67  THR A C     1 ? 
ATOM   520  O  O     . THR A 1 67  ? 10.144  -3.220  13.450  1.000 20.627  ? 67  THR A O     1 ? 
ATOM   521  C  CB    . THR A 1 67  ? 7.933   -4.199  12.055  1.000 15.847  ? 67  THR A CB    1 ? 
ATOM   522  O  OG1   . THR A 1 67  ? 7.775   -2.916  11.433  1.000 15.665  ? 67  THR A OG1   1 ? 
ATOM   523  C  CG2   . THR A 1 67  ? 6.863   -5.152  11.593  1.000 14.420  ? 67  THR A CG2   1 ? 
ATOM   524  N  N     . GLY A 1 68  ? 8.809   -2.151  14.907  1.000 19.387  ? 68  GLY A N     1 ? 
ATOM   525  C  CA    . GLY A 1 68  ? 9.782   -1.151  15.361  1.000 20.919  ? 68  GLY A CA    1 ? 
ATOM   526  C  C     . GLY A 1 68  ? 10.746  -1.742  16.362  1.000 20.362  ? 68  GLY A C     1 ? 
ATOM   527  O  O     . GLY A 1 68  ? 10.323  -2.639  17.140  1.000 21.644  ? 68  GLY A O     1 ? 
ATOM   528  N  N     . VAL A 1 69  ? 11.996  -1.278  16.317  1.000 19.401  ? 69  VAL A N     1 ? 
ATOM   529  C  CA    . VAL A 1 69  ? 13.065  -1.636  17.280  1.000 20.998  ? 69  VAL A CA    1 ? 
ATOM   530  C  C     . VAL A 1 69  ? 13.605  -0.365  17.925  1.000 22.919  ? 69  VAL A C     1 ? 
ATOM   531  O  O     . VAL A 1 69  ? 13.443  0.716   17.341  1.000 24.955  ? 69  VAL A O     1 ? 
ATOM   532  C  CB    . VAL A 1 69  ? 14.190  -2.432  16.618  1.000 20.219  ? 69  VAL A CB    1 ? 
ATOM   533  C  CG1   . VAL A 1 69  ? 13.673  -3.755  16.114  1.000 19.349  ? 69  VAL A CG1   1 ? 
ATOM   534  C  CG2   . VAL A 1 69  ? 14.873  -1.651  15.506  1.000 20.468  ? 69  VAL A CG2   1 ? 
ATOM   535  N  N     . LYS A 1 70  ? 14.194  -0.509  19.112  1.000 20.797  ? 70  LYS A N     1 ? 
ATOM   536  C  CA    . LYS A 1 70  ? 14.836  0.608   19.824  1.000 21.089  ? 70  LYS A CA    1 ? 
ATOM   537  C  C     . LYS A 1 70  ? 16.161  0.869   19.147  1.000 19.468  ? 70  LYS A C     1 ? 
ATOM   538  O  O     . LYS A 1 70  ? 16.872  -0.065  18.794  1.000 17.316  ? 70  LYS A O     1 ? 
ATOM   539  C  CB    . LYS A 1 70  ? 15.008  0.264   21.307  1.000 22.341  ? 70  LYS A CB    1 ? 
ATOM   540  C  CG    . LYS A 1 70  ? 13.717  -0.129  21.997  1.000 23.855  ? 70  LYS A CG    1 ? 
ATOM   541  C  CD    . LYS A 1 70  ? 13.839  -0.331  23.479  1.000 27.593  ? 70  LYS A CD    1 ? 
ATOM   542  C  CE    . LYS A 1 70  ? 12.476  -0.392  24.154  1.000 29.704  ? 70  LYS A CE    1 ? 
ATOM   543  N  NZ    . LYS A 1 70  ? 12.512  -1.268  25.350  1.000 32.229  ? 70  LYS A NZ    1 ? 
ATOM   544  N  N     . PRO A 1 71  ? 16.532  2.149   18.952  1.000 21.031  ? 71  PRO A N     1 ? 
ATOM   545  C  CA    . PRO A 1 71  ? 17.843  2.481   18.416  1.000 22.406  ? 71  PRO A CA    1 ? 
ATOM   546  C  C     . PRO A 1 71  ? 18.955  1.942   19.316  1.000 25.592  ? 71  PRO A C     1 ? 
ATOM   547  O  O     . PRO A 1 71  ? 18.696  1.670   20.499  1.000 25.641  ? 71  PRO A O     1 ? 
ATOM   548  C  CB    . PRO A 1 71  ? 17.850  4.015   18.365  1.000 23.213  ? 71  PRO A CB    1 ? 
ATOM   549  C  CG    . PRO A 1 71  ? 16.733  4.428   19.303  1.000 22.848  ? 71  PRO A CG    1 ? 
ATOM   550  C  CD    . PRO A 1 71  ? 15.708  3.329   19.222  1.000 21.182  ? 71  PRO A CD    1 ? 
ATOM   551  N  N     . LEU A 1 72  ? 20.151  1.795   18.746  1.000 27.677  ? 72  LEU A N     1 ? 
ATOM   552  C  CA    . LEU A 1 72  ? 21.400  1.559   19.513  1.000 31.941  ? 72  LEU A CA    1 ? 
ATOM   553  C  C     . LEU A 1 72  ? 21.777  2.868   20.207  1.000 38.152  ? 72  LEU A C     1 ? 
ATOM   554  O  O     . LEU A 1 72  ? 20.995  3.837   20.089  1.000 38.803  ? 72  LEU A O     1 ? 
ATOM   555  C  CB    . LEU A 1 72  ? 22.482  1.077   18.541  1.000 35.733  ? 72  LEU A CB    1 ? 
ATOM   556  C  CG    . LEU A 1 72  ? 22.329  -0.370  18.058  1.000 36.301  ? 72  LEU A CG    1 ? 
ATOM   557  C  CD1   . LEU A 1 72  ? 23.198  -0.644  16.844  1.000 36.732  ? 72  LEU A CD1   1 ? 
ATOM   558  C  CD2   . LEU A 1 72  ? 22.664  -1.351  19.168  1.000 38.968  ? 72  LEU A CD2   1 ? 
ATOM   559  N  N     . GLU A 1 73  ? 22.909  2.919   20.913  1.000 45.350  ? 73  GLU A N     1 ? 
ATOM   560  C  CA    . GLU A 1 73  ? 23.408  4.188   21.502  1.000 46.666  ? 73  GLU A CA    1 ? 
ATOM   561  C  C     . GLU A 1 73  ? 24.073  5.014   20.401  1.000 43.934  ? 73  GLU A C     1 ? 
ATOM   562  O  O     . GLU A 1 73  ? 24.825  4.434   19.575  1.000 42.207  ? 73  GLU A O     1 ? 
ATOM   563  C  CB    . GLU A 1 73  ? 24.380  3.950   22.652  1.000 55.250  ? 73  GLU A CB    1 ? 
ATOM   564  C  CG    . GLU A 1 73  ? 24.866  5.246   23.268  1.000 58.597  ? 73  GLU A CG    1 ? 
ATOM   565  C  CD    . GLU A 1 73  ? 25.720  5.061   24.501  1.000 63.522  ? 73  GLU A CD    1 ? 
ATOM   566  O  OE1   . GLU A 1 73  ? 26.889  5.508   24.474  1.000 68.423  ? 73  GLU A OE1   1 ? 
ATOM   567  O  OE2   . GLU A 1 73  ? 25.214  4.470   25.482  1.000 63.055  ? 73  GLU A OE2   1 ? 
ATOM   568  N  N     . GLY A 1 74  ? 23.789  6.317   20.384  1.000 46.804  ? 74  GLY A N     1 ? 
ATOM   569  C  CA    . GLY A 1 74  ? 24.210  7.236   19.310  1.000 51.425  ? 74  GLY A CA    1 ? 
ATOM   570  C  C     . GLY A 1 74  ? 23.517  6.935   17.989  1.000 51.360  ? 74  GLY A C     1 ? 
ATOM   571  O  O     . GLY A 1 74  ? 24.031  7.388   16.946  1.000 52.468  ? 74  GLY A O     1 ? 
ATOM   572  N  N     . GLY A 1 75  ? 22.420  6.163   18.026  1.000 54.742  ? 75  GLY A N     1 ? 
ATOM   573  C  CA    . GLY A 1 75  ? 21.435  6.036   16.935  1.000 51.792  ? 75  GLY A CA    1 ? 
ATOM   574  C  C     . GLY A 1 75  ? 20.271  6.979   17.174  1.000 52.803  ? 75  GLY A C     1 ? 
ATOM   575  O  O     . GLY A 1 75  ? 20.361  7.792   18.098  1.000 55.040  ? 75  GLY A O     1 ? 
ATOM   576  N  N     . GLU A 1 76  ? 19.209  6.884   16.380  1.000 49.220  ? 76  GLU A N     1 ? 
ATOM   577  C  CA    . GLU A 1 76  ? 18.052  7.812   16.457  1.000 48.765  ? 76  GLU A CA    1 ? 
ATOM   578  C  C     . GLU A 1 76  ? 16.769  7.017   16.193  1.000 43.398  ? 76  GLU A C     1 ? 
ATOM   579  O  O     . GLU A 1 76  ? 16.767  6.233   15.247  1.000 39.668  ? 76  GLU A O     1 ? 
ATOM   580  C  CB    . GLU A 1 76  ? 18.232  8.955   15.451  1.000 54.775  ? 76  GLU A CB    1 ? 
ATOM   581  C  CG    . GLU A 1 76  ? 19.476  9.806   15.698  1.000 57.528  ? 76  GLU A CG    1 ? 
ATOM   582  C  CD    . GLU A 1 76  ? 19.740  10.898  14.671  1.000 60.112  ? 76  GLU A CD    1 ? 
ATOM   583  O  OE1   . GLU A 1 76  ? 20.551  11.802  14.966  1.000 58.515  ? 76  GLU A OE1   1 ? 
ATOM   584  O  OE2   . GLU A 1 76  ? 19.151  10.834  13.572  1.000 66.273  ? 76  GLU A OE2   1 ? 
ATOM   585  N  N     . TYR A 1 77  ? 15.740  7.195   17.029  1.000 40.977  ? 77  TYR A N     1 ? 
ATOM   586  C  CA    . TYR A 1 77  ? 14.355  6.743   16.746  1.000 41.172  ? 77  TYR A CA    1 ? 
ATOM   587  C  C     . TYR A 1 77  ? 13.957  7.281   15.368  1.000 38.965  ? 77  TYR A C     1 ? 
ATOM   588  O  O     . TYR A 1 77  ? 14.343  8.420   15.041  1.000 38.765  ? 77  TYR A O     1 ? 
ATOM   589  C  CB    . TYR A 1 77  ? 13.375  7.228   17.814  1.000 40.714  ? 77  TYR A CB    1 ? 
ATOM   590  C  CG    . TYR A 1 77  ? 13.494  6.598   19.181  1.000 43.838  ? 77  TYR A CG    1 ? 
ATOM   591  C  CD1   . TYR A 1 77  ? 12.875  5.390   19.472  1.000 48.082  ? 77  TYR A CD1   1 ? 
ATOM   592  C  CD2   . TYR A 1 77  ? 14.133  7.255   20.222  1.000 44.640  ? 77  TYR A CD2   1 ? 
ATOM   593  C  CE1   . TYR A 1 77  ? 12.933  4.826   20.739  1.000 46.516  ? 77  TYR A CE1   1 ? 
ATOM   594  C  CE2   . TYR A 1 77  ? 14.203  6.703   21.493  1.000 43.688  ? 77  TYR A CE2   1 ? 
ATOM   595  C  CZ    . TYR A 1 77  ? 13.597  5.486   21.754  1.000 45.344  ? 77  TYR A CZ    1 ? 
ATOM   596  O  OH    . TYR A 1 77  ? 13.658  4.923   22.996  1.000 45.917  ? 77  TYR A OH    1 ? 
ATOM   597  N  N     . ASP A 1 78  ? 13.253  6.479   14.567  1.000 35.637  ? 78  ASP A N     1 ? 
ATOM   598  C  CA    . ASP A 1 78  ? 12.860  6.857   13.188  1.000 33.968  ? 78  ASP A CA    1 ? 
ATOM   599  C  C     . ASP A 1 78  ? 11.332  6.937   13.116  1.000 37.515  ? 78  ASP A C     1 ? 
ATOM   600  O  O     . ASP A 1 78  ? 10.698  5.936   12.749  1.000 33.874  ? 78  ASP A O     1 ? 
ATOM   601  C  CB    . ASP A 1 78  ? 13.432  5.895   12.156  1.000 35.368  ? 78  ASP A CB    1 ? 
ATOM   602  C  CG    . ASP A 1 78  ? 12.935  6.201   10.762  1.000 37.266  ? 78  ASP A CG    1 ? 
ATOM   603  O  OD1   . ASP A 1 78  ? 13.293  7.272   10.244  1.000 37.971  ? 78  ASP A OD1   1 ? 
ATOM   604  O  OD2   . ASP A 1 78  ? 12.147  5.397   10.233  1.000 37.592  ? 78  ASP A OD2   1 ? 
ATOM   605  N  N     . ILE A 1 79  ? 10.774  8.102   13.455  1.000 37.450  ? 79  ILE A N     1 ? 
ATOM   606  C  CA    . ILE A 1 79  ? 9.307   8.343   13.519  1.000 38.991  ? 79  ILE A CA    1 ? 
ATOM   607  C  C     . ILE A 1 79  ? 8.828   8.758   12.134  1.000 37.856  ? 79  ILE A C     1 ? 
ATOM   608  O  O     . ILE A 1 79  ? 9.288   9.796   11.637  1.000 42.718  ? 79  ILE A O     1 ? 
ATOM   609  C  CB    . ILE A 1 79  ? 8.951   9.395   14.581  1.000 42.104  ? 79  ILE A CB    1 ? 
ATOM   610  C  CG1   . ILE A 1 79  ? 9.642   9.110   15.920  1.000 41.372  ? 79  ILE A CG1   1 ? 
ATOM   611  C  CG2   . ILE A 1 79  ? 7.436   9.493   14.716  1.000 44.628  ? 79  ILE A CG2   1 ? 
ATOM   612  C  CD1   . ILE A 1 79  ? 9.451   10.197  16.965  1.000 41.683  ? 79  ILE A CD1   1 ? 
ATOM   613  N  N     . ASP A 1 80  ? 7.935   7.957   11.556  1.000 36.956  ? 80  ASP A N     1 ? 
ATOM   614  C  CA    . ASP A 1 80  ? 7.443   8.077   10.162  1.000 35.226  ? 80  ASP A CA    1 ? 
ATOM   615  C  C     . ASP A 1 80  ? 5.945   8.410   10.212  1.000 33.387  ? 80  ASP A C     1 ? 
ATOM   616  O  O     . ASP A 1 80  ? 5.156   7.532   10.668  1.000 28.997  ? 80  ASP A O     1 ? 
ATOM   617  C  CB    . ASP A 1 80  ? 7.689   6.782   9.372   1.000 34.544  ? 80  ASP A CB    1 ? 
ATOM   618  C  CG    . ASP A 1 80  ? 9.132   6.313   9.328   1.000 34.420  ? 80  ASP A CG    1 ? 
ATOM   619  O  OD1   . ASP A 1 80  ? 9.343   5.092   9.523   1.000 30.559  ? 80  ASP A OD1   1 ? 
ATOM   620  O  OD2   . ASP A 1 80  ? 10.037  7.164   9.073   1.000 33.548  ? 80  ASP A OD2   1 ? 
ATOM   621  N  N     . VAL A 1 81  ? 5.586   9.625   9.790   1.000 31.034  ? 81  VAL A N     1 ? 
ATOM   622  C  CA    . VAL A 1 81  ? 4.185   10.076  9.553   1.000 32.729  ? 81  VAL A CA    1 ? 
ATOM   623  C  C     . VAL A 1 81  ? 4.040   10.476  8.093   1.000 29.608  ? 81  VAL A C     1 ? 
ATOM   624  O  O     . VAL A 1 81  ? 5.004   10.993  7.518   1.000 32.755  ? 81  VAL A O     1 ? 
ATOM   625  C  CB    . VAL A 1 81  ? 3.768   11.231  10.475  1.000 34.404  ? 81  VAL A CB    1 ? 
ATOM   626  C  CG1   . VAL A 1 81  ? 3.655   10.764  11.896  1.000 35.563  ? 81  VAL A CG1   1 ? 
ATOM   627  C  CG2   . VAL A 1 81  ? 4.707   12.421  10.378  1.000 38.220  ? 81  VAL A CG2   1 ? 
ATOM   628  N  N     . GLY A 1 82  ? 2.885   10.196  7.517   1.000 27.604  ? 82  GLY A N     1 ? 
ATOM   629  C  CA    . GLY A 1 82  ? 2.453   10.784  6.242   1.000 28.575  ? 82  GLY A CA    1 ? 
ATOM   630  C  C     . GLY A 1 82  ? 1.644   12.024  6.545   1.000 32.176  ? 82  GLY A C     1 ? 
ATOM   631  O  O     . GLY A 1 82  ? 1.132   12.117  7.690   1.000 32.040  ? 82  GLY A O     1 ? 
ATOM   632  N  N     . ILE A 1 83  ? 1.583   12.963  5.602   1.000 32.097  ? 83  ILE A N     1 ? 
ATOM   633  C  CA    . ILE A 1 83  ? 0.680   14.156  5.654   1.000 32.211  ? 83  ILE A CA    1 ? 
ATOM   634  C  C     . ILE A 1 83  ? 0.089   14.380  4.252   1.000 32.212  ? 83  ILE A C     1 ? 
ATOM   635  O  O     . ILE A 1 83  ? 0.856   14.419  3.253   1.000 29.789  ? 83  ILE A O     1 ? 
ATOM   636  C  CB    . ILE A 1 83  ? 1.408   15.394  6.216   1.000 33.090  ? 83  ILE A CB    1 ? 
ATOM   637  C  CG1   . ILE A 1 83  ? 2.692   15.721  5.445   1.000 32.075  ? 83  ILE A CG1   1 ? 
ATOM   638  C  CG2   . ILE A 1 83  ? 1.678   15.213  7.707   1.000 31.947  ? 83  ILE A CG2   1 ? 
ATOM   639  C  CD1   . ILE A 1 83  ? 3.147   17.151  5.593   1.000 33.532  ? 83  ILE A CD1   1 ? 
ATOM   640  N  N     . ILE A 1 84  ? -1.242  14.396  4.174   1.000 33.333  ? 84  ILE A N     1 ? 
ATOM   641  C  CA    . ILE A 1 84  ? -1.989  14.624  2.907   1.000 38.699  ? 84  ILE A CA    1 ? 
ATOM   642  C  C     . ILE A 1 84  ? -2.543  16.057  2.946   1.000 43.837  ? 84  ILE A C     1 ? 
ATOM   643  O  O     . ILE A 1 84  ? -3.412  16.340  3.796   1.000 44.287  ? 84  ILE A O     1 ? 
ATOM   644  C  CB    . ILE A 1 84  ? -3.076  13.550  2.695   1.000 35.876  ? 84  ILE A CB    1 ? 
ATOM   645  C  CG1   . ILE A 1 84  ? -2.612  12.159  3.151   1.000 34.335  ? 84  ILE A CG1   1 ? 
ATOM   646  C  CG2   . ILE A 1 84  ? -3.516  13.534  1.243   1.000 36.532  ? 84  ILE A CG2   1 ? 
ATOM   647  C  CD1   . ILE A 1 84  ? -3.685  11.094  3.107   1.000 32.474  ? 84  ILE A CD1   1 ? 
ATOM   648  N  N     . LEU A 1 85  ? -1.956  16.939  2.132   1.000 51.124  ? 85  LEU A N     1 ? 
ATOM   649  C  CA    . LEU A 1 85  ? -2.357  18.366  1.948   1.000 53.084  ? 85  LEU A CA    1 ? 
ATOM   650  C  C     . LEU A 1 85  ? -3.472  18.432  0.899   1.000 51.826  ? 85  LEU A C     1 ? 
ATOM   651  O  O     . LEU A 1 85  ? -3.428  17.621  -0.068  1.000 55.661  ? 85  LEU A O     1 ? 
ATOM   652  C  CB    . LEU A 1 85  ? -1.145  19.177  1.469   1.000 50.515  ? 85  LEU A CB    1 ? 
ATOM   653  C  CG    . LEU A 1 85  ? 0.026   19.297  2.436   1.000 46.918  ? 85  LEU A CG    1 ? 
ATOM   654  C  CD1   . LEU A 1 85  ? 1.293   19.671  1.687   1.000 50.848  ? 85  LEU A CD1   1 ? 
ATOM   655  C  CD2   . LEU A 1 85  ? -0.265  20.317  3.509   1.000 45.877  ? 85  LEU A CD2   1 ? 
ATOM   656  N  N     . ASN A 1 86  ? -4.412  19.370  1.054   1.000 57.539  ? 86  ASN A N     1 ? 
ATOM   657  C  CA    . ASN A 1 86  ? -5.532  19.559  0.092   1.000 58.211  ? 86  ASN A CA    1 ? 
ATOM   658  C  C     . ASN A 1 86  ? -5.025  20.478  -1.030  1.000 55.892  ? 86  ASN A C     1 ? 
ATOM   659  O  O     . ASN A 1 86  ? -5.102  21.714  -0.882  1.000 56.548  ? 86  ASN A O     1 ? 
ATOM   660  C  CB    . ASN A 1 86  ? -6.838  19.948  0.809   1.000 62.767  ? 86  ASN A CB    1 ? 
ATOM   661  C  CG    . ASN A 1 86  ? -7.101  21.434  0.943   1.000 69.069  ? 86  ASN A CG    1 ? 
ATOM   662  O  OD1   . ASN A 1 86  ? -6.297  22.171  1.516   1.000 70.033  ? 86  ASN A OD1   1 ? 
ATOM   663  N  ND2   . ASN A 1 86  ? -8.261  21.870  0.469   1.000 60.281  ? 86  ASN A ND2   1 ? 
ATOM   664  N  N     . ILE A 1 87  ? -4.419  19.868  -2.058  1.000 47.484  ? 87  ILE A N     1 ? 
ATOM   665  C  CA    . ILE A 1 87  ? -3.870  20.538  -3.276  1.000 43.896  ? 87  ILE A CA    1 ? 
ATOM   666  C  C     . ILE A 1 87  ? -4.004  19.567  -4.448  1.000 45.261  ? 87  ILE A C     1 ? 
ATOM   667  O  O     . ILE A 1 87  ? -4.168  18.358  -4.199  1.000 48.693  ? 87  ILE A O     1 ? 
ATOM   668  C  CB    . ILE A 1 87  ? -2.401  20.954  -3.072  1.000 42.710  ? 87  ILE A CB    1 ? 
ATOM   669  C  CG1   . ILE A 1 87  ? -1.471  19.732  -3.116  1.000 42.692  ? 87  ILE A CG1   1 ? 
ATOM   670  C  CG2   . ILE A 1 87  ? -2.236  21.777  -1.799  1.000 40.572  ? 87  ILE A CG2   1 ? 
ATOM   671  C  CD1   . ILE A 1 87  ? -0.213  19.852  -2.268  1.000 41.372  ? 87  ILE A CD1   1 ? 
ATOM   672  N  N     . ALA A 1 88  ? -3.912  20.065  -5.680  1.000 47.929  ? 88  ALA A N     1 ? 
ATOM   673  C  CA    . ALA A 1 88  ? -3.915  19.241  -6.913  1.000 47.424  ? 88  ALA A CA    1 ? 
ATOM   674  C  C     . ALA A 1 88  ? -2.467  18.920  -7.293  1.000 47.936  ? 88  ALA A C     1 ? 
ATOM   675  O  O     . ALA A 1 88  ? -1.617  19.808  -7.184  1.000 49.424  ? 88  ALA A O     1 ? 
ATOM   676  C  CB    . ALA A 1 88  ? -4.644  19.953  -8.029  1.000 46.236  ? 88  ALA A CB    1 ? 
ATOM   677  N  N     . LYS A 1 89  ? -2.195  17.671  -7.662  1.000 51.693  ? 89  LYS A N     1 ? 
ATOM   678  C  CA    . LYS A 1 89  ? -0.827  17.190  -7.984  1.000 49.344  ? 89  LYS A CA    1 ? 
ATOM   679  C  C     . LYS A 1 89  ? -0.343  17.856  -9.282  1.000 55.913  ? 89  LYS A C     1 ? 
ATOM   680  O  O     . LYS A 1 89  ? 0.886   17.966  -9.473  1.000 66.080  ? 89  LYS A O     1 ? 
ATOM   681  C  CB    . LYS A 1 89  ? -0.801  15.662  -8.083  1.000 44.714  ? 89  LYS A CB    1 ? 
ATOM   682  C  CG    . LYS A 1 89  ? -1.596  15.056  -9.232  1.000 44.794  ? 89  LYS A CG    1 ? 
ATOM   683  C  CD    . LYS A 1 89  ? -1.481  13.558  -9.298  1.000 42.344  ? 89  LYS A CD    1 ? 
ATOM   684  C  CE    . LYS A 1 89  ? -2.367  12.932  -10.347 1.000 44.038  ? 89  LYS A CE    1 ? 
ATOM   685  N  NZ    . LYS A 1 89  ? -1.621  12.616  -11.583 1.000 44.320  ? 89  LYS A NZ    1 ? 
ATOM   686  N  N     . ASP A 1 90  ? -1.262  18.303  -10.136 1.000 56.874  ? 90  ASP A N     1 ? 
ATOM   687  C  CA    . ASP A 1 90  ? -0.931  18.831  -11.484 1.000 58.447  ? 90  ASP A CA    1 ? 
ATOM   688  C  C     . ASP A 1 90  ? -0.817  20.371  -11.447 1.000 60.432  ? 90  ASP A C     1 ? 
ATOM   689  O  O     . ASP A 1 90  ? -0.672  20.969  -12.549 1.000 64.077  ? 90  ASP A O     1 ? 
ATOM   690  C  CB    . ASP A 1 90  ? -1.950  18.317  -12.505 1.000 59.242  ? 90  ASP A CB    1 ? 
ATOM   691  C  CG    . ASP A 1 90  ? -1.860  16.822  -12.744 1.000 59.820  ? 90  ASP A CG    1 ? 
ATOM   692  O  OD1   . ASP A 1 90  ? -0.744  16.277  -12.625 1.000 61.792  ? 90  ASP A OD1   1 ? 
ATOM   693  O  OD2   . ASP A 1 90  ? -2.903  16.213  -13.044 1.000 59.065  ? 90  ASP A OD2   1 ? 
ATOM   694  N  N     . ASP A 1 91  ? -0.823  20.982  -10.246 1.000 56.831  ? 91  ASP A N     1 ? 
ATOM   695  C  CA    . ASP A 1 91  ? -0.811  22.459  -10.027 1.000 54.074  ? 91  ASP A CA    1 ? 
ATOM   696  C  C     . ASP A 1 91  ? 0.508   22.892  -9.392  1.000 57.676  ? 91  ASP A C     1 ? 
ATOM   697  O  O     . ASP A 1 91  ? 1.092   23.872  -9.869  1.000 51.016  ? 91  ASP A O     1 ? 
ATOM   698  C  CB    . ASP A 1 91  ? -1.949  22.920  -9.116  1.000 52.538  ? 91  ASP A CB    1 ? 
ATOM   699  C  CG    . ASP A 1 91  ? -3.259  23.073  -9.850  1.000 53.510  ? 91  ASP A CG    1 ? 
ATOM   700  O  OD1   . ASP A 1 91  ? -4.310  23.220  -9.171  1.000 53.558  ? 91  ASP A OD1   1 ? 
ATOM   701  O  OD2   . ASP A 1 91  ? -3.219  23.025  -11.093 1.000 50.174  ? 91  ASP A OD2   1 ? 
ATOM   702  N  N     . HIS A 1 92  ? 0.924   22.212  -8.325  1.000 60.196  ? 92  HIS A N     1 ? 
ATOM   703  C  CA    . HIS A 1 92  ? 2.143   22.536  -7.546  1.000 58.601  ? 92  HIS A CA    1 ? 
ATOM   704  C  C     . HIS A 1 92  ? 3.291   21.599  -7.935  1.000 52.617  ? 92  HIS A C     1 ? 
ATOM   705  O  O     . HIS A 1 92  ? 3.063   20.637  -8.689  1.000 44.998  ? 92  HIS A O     1 ? 
ATOM   706  C  CB    . HIS A 1 92  ? 1.860   22.459  -6.048  1.000 63.266  ? 92  HIS A CB    1 ? 
ATOM   707  C  CG    . HIS A 1 92  ? 0.921   23.502  -5.548  1.000 67.434  ? 92  HIS A CG    1 ? 
ATOM   708  N  ND1   . HIS A 1 92  ? 1.319   24.474  -4.654  1.000 66.543  ? 92  HIS A ND1   1 ? 
ATOM   709  C  CD2   . HIS A 1 92  ? -0.400  23.696  -5.761  1.000 66.734  ? 92  HIS A CD2   1 ? 
ATOM   710  C  CE1   . HIS A 1 92  ? 0.289   25.242  -4.358  1.000 68.038  ? 92  HIS A CE1   1 ? 
ATOM   711  N  NE2   . HIS A 1 92  ? -0.780  24.779  -5.015  1.000 70.016  ? 92  HIS A NE2   1 ? 
ATOM   712  N  N     . ASP A 1 93  ? 4.488   21.919  -7.439  1.000 52.010  ? 93  ASP A N     1 ? 
ATOM   713  C  CA    . ASP A 1 93  ? 5.754   21.190  -7.689  1.000 48.537  ? 93  ASP A CA    1 ? 
ATOM   714  C  C     . ASP A 1 93  ? 6.131   20.396  -6.432  1.000 47.152  ? 93  ASP A C     1 ? 
ATOM   715  O  O     . ASP A 1 93  ? 6.142   20.924  -5.311  1.000 47.307  ? 93  ASP A O     1 ? 
ATOM   716  C  CB    . ASP A 1 93  ? 6.866   22.162  -8.078  1.000 47.445  ? 93  ASP A CB    1 ? 
ATOM   717  C  CG    . ASP A 1 93  ? 8.229   21.550  -7.872  1.000 45.748  ? 93  ASP A CG    1 ? 
ATOM   718  O  OD1   . ASP A 1 93  ? 8.731   20.941  -8.840  1.000 40.783  ? 93  ASP A OD1   1 ? 
ATOM   719  O  OD2   . ASP A 1 93  ? 8.725   21.604  -6.711  1.000 43.807  ? 93  ASP A OD2   1 ? 
ATOM   720  N  N     . PRO A 1 94  ? 6.463   19.099  -6.576  1.000 41.328  ? 94  PRO A N     1 ? 
ATOM   721  C  CA    . PRO A 1 94  ? 6.749   18.243  -5.418  1.000 37.275  ? 94  PRO A CA    1 ? 
ATOM   722  C  C     . PRO A 1 94  ? 7.711   18.819  -4.368  1.000 38.927  ? 94  PRO A C     1 ? 
ATOM   723  O  O     . PRO A 1 94  ? 7.414   18.738  -3.178  1.000 35.994  ? 94  PRO A O     1 ? 
ATOM   724  C  CB    . PRO A 1 94  ? 7.371   17.025  -6.094  1.000 42.222  ? 94  PRO A CB    1 ? 
ATOM   725  C  CG    . PRO A 1 94  ? 6.629   16.930  -7.416  1.000 45.060  ? 94  PRO A CG    1 ? 
ATOM   726  C  CD    . PRO A 1 94  ? 6.485   18.371  -7.853  1.000 41.658  ? 94  PRO A CD    1 ? 
ATOM   727  N  N     . VAL A 1 95  ? 8.827   19.414  -4.810  1.000 42.837  ? 95  VAL A N     1 ? 
ATOM   728  C  CA    . VAL A 1 95  ? 9.909   19.892  -3.897  1.000 40.014  ? 95  VAL A CA    1 ? 
ATOM   729  C  C     . VAL A 1 95  ? 9.418   21.184  -3.247  1.000 39.562  ? 95  VAL A C     1 ? 
ATOM   730  O  O     . VAL A 1 95  ? 9.528   21.327  -2.002  1.000 34.149  ? 95  VAL A O     1 ? 
ATOM   731  C  CB    . VAL A 1 95  ? 11.260  20.094  -4.613  1.000 41.660  ? 95  VAL A CB    1 ? 
ATOM   732  C  CG1   . VAL A 1 95  ? 12.396  20.203  -3.610  1.000 42.318  ? 95  VAL A CG1   1 ? 
ATOM   733  C  CG2   . VAL A 1 95  ? 11.566  18.999  -5.626  1.000 39.405  ? 95  VAL A CG2   1 ? 
ATOM   734  N  N     . GLU A 1 96  ? 8.850   22.073  -4.059  1.000 43.560  ? 96  GLU A N     1 ? 
ATOM   735  C  CA    . GLU A 1 96  ? 8.214   23.320  -3.578  1.000 46.102  ? 96  GLU A CA    1 ? 
ATOM   736  C  C     . GLU A 1 96  ? 7.411   22.970  -2.323  1.000 43.355  ? 96  GLU A C     1 ? 
ATOM   737  O  O     . GLU A 1 96  ? 7.693   23.547  -1.237  1.000 41.458  ? 96  GLU A O     1 ? 
ATOM   738  C  CB    . GLU A 1 96  ? 7.342   23.912  -4.688  1.000 55.984  ? 96  GLU A CB    1 ? 
ATOM   739  C  CG    . GLU A 1 96  ? 6.719   25.253  -4.332  1.000 60.895  ? 96  GLU A CG    1 ? 
ATOM   740  C  CD    . GLU A 1 96  ? 7.698   26.411  -4.210  1.000 64.755  ? 96  GLU A CD    1 ? 
ATOM   741  O  OE1   . GLU A 1 96  ? 8.931   26.175  -4.344  1.000 61.822  ? 96  GLU A OE1   1 ? 
ATOM   742  O  OE2   . GLU A 1 96  ? 7.228   27.552  -3.986  1.000 67.805  ? 96  GLU A OE2   1 ? 
ATOM   743  N  N     . VAL A 1 97  ? 6.517   21.989  -2.460  1.000 40.684  ? 97  VAL A N     1 ? 
ATOM   744  C  CA    . VAL A 1 97  ? 5.542   21.578  -1.409  1.000 37.531  ? 97  VAL A CA    1 ? 
ATOM   745  C  C     . VAL A 1 97  ? 6.339   21.081  -0.197  1.000 35.002  ? 97  VAL A C     1 ? 
ATOM   746  O  O     . VAL A 1 97  ? 6.021   21.486  0.940   1.000 35.117  ? 97  VAL A O     1 ? 
ATOM   747  C  CB    . VAL A 1 97  ? 4.542   20.536  -1.954  1.000 37.267  ? 97  VAL A CB    1 ? 
ATOM   748  C  CG1   . VAL A 1 97  ? 3.502   20.152  -0.916  1.000 35.538  ? 97  VAL A CG1   1 ? 
ATOM   749  C  CG2   . VAL A 1 97  ? 3.852   21.017  -3.229  1.000 34.533  ? 97  VAL A CG2   1 ? 
ATOM   750  N  N     . LYS A 1 98  ? 7.411   20.324  -0.433  1.000 39.462  ? 98  LYS A N     1 ? 
ATOM   751  C  CA    . LYS A 1 98  ? 8.338   19.873  0.641   1.000 40.374  ? 98  LYS A CA    1 ? 
ATOM   752  C  C     . LYS A 1 98  ? 9.034   21.095  1.262   1.000 45.745  ? 98  LYS A C     1 ? 
ATOM   753  O  O     . LYS A 1 98  ? 9.054   21.180  2.521   1.000 42.390  ? 98  LYS A O     1 ? 
ATOM   754  C  CB    . LYS A 1 98  ? 9.301   18.810  0.100   1.000 42.526  ? 98  LYS A CB    1 ? 
ATOM   755  C  CG    . LYS A 1 98  ? 8.720   17.397  0.077   1.000 42.194  ? 98  LYS A CG    1 ? 
ATOM   756  C  CD    . LYS A 1 98  ? 9.687   16.313  -0.371  1.000 39.146  ? 98  LYS A CD    1 ? 
ATOM   757  C  CE    . LYS A 1 98  ? 9.638   16.054  -1.862  1.000 32.849  ? 98  LYS A CE    1 ? 
ATOM   758  N  NZ    . LYS A 1 98  ? 10.586  14.998  -2.263  1.000 29.527  ? 98  LYS A NZ    1 ? 
ATOM   759  N  N     . LYS A 1 99  ? 9.493   22.049  0.427   1.000 52.810  ? 99  LYS A N     1 ? 
ATOM   760  C  CA    . LYS A 1 99  ? 10.086  23.347  0.874   1.000 53.509  ? 99  LYS A CA    1 ? 
ATOM   761  C  C     . LYS A 1 99  ? 9.168   23.979  1.923   1.000 49.105  ? 99  LYS A C     1 ? 
ATOM   762  O  O     . LYS A 1 99  ? 9.682   24.351  2.996   1.000 45.599  ? 99  LYS A O     1 ? 
ATOM   763  C  CB    . LYS A 1 99  ? 10.309  24.327  -0.285  1.000 59.698  ? 99  LYS A CB    1 ? 
ATOM   764  C  CG    . LYS A 1 99  ? 11.348  23.910  -1.324  1.000 63.234  ? 99  LYS A CG    1 ? 
ATOM   765  C  CD    . LYS A 1 99  ? 12.139  25.080  -1.910  1.000 64.137  ? 99  LYS A CD    1 ? 
ATOM   766  C  CE    . LYS A 1 99  ? 13.197  24.654  -2.910  1.000 69.567  ? 99  LYS A CE    1 ? 
ATOM   767  N  NZ    . LYS A 1 99  ? 13.955  25.814  -3.447  1.000 71.796  ? 99  LYS A NZ    1 ? 
ATOM   768  N  N     . TRP A 1 100 ? 7.863   24.053  1.639   1.000 47.197  ? 100 TRP A N     1 ? 
ATOM   769  C  CA    . TRP A 1 100 ? 6.851   24.547  2.604   1.000 51.469  ? 100 TRP A CA    1 ? 
ATOM   770  C  C     . TRP A 1 100 ? 7.185   23.937  3.971   1.000 55.060  ? 100 TRP A C     1 ? 
ATOM   771  O  O     . TRP A 1 100 ? 7.483   24.708  4.918   1.000 59.653  ? 100 TRP A O     1 ? 
ATOM   772  C  CB    . TRP A 1 100 ? 5.403   24.219  2.176   1.000 57.439  ? 100 TRP A CB    1 ? 
ATOM   773  C  CG    . TRP A 1 100 ? 4.979   24.649  0.796   1.000 60.778  ? 100 TRP A CG    1 ? 
ATOM   774  C  CD1   . TRP A 1 100 ? 5.629   25.501  -0.052  1.000 61.874  ? 100 TRP A CD1   1 ? 
ATOM   775  C  CD2   . TRP A 1 100 ? 3.757   24.282  0.119   1.000 60.819  ? 100 TRP A CD2   1 ? 
ATOM   776  N  NE1   . TRP A 1 100 ? 4.926   25.650  -1.220  1.000 60.848  ? 100 TRP A NE1   1 ? 
ATOM   777  C  CE2   . TRP A 1 100 ? 3.769   24.925  -1.142  1.000 60.180  ? 100 TRP A CE2   1 ? 
ATOM   778  C  CE3   . TRP A 1 100 ? 2.669   23.459  0.442   1.000 56.229  ? 100 TRP A CE3   1 ? 
ATOM   779  C  CZ2   . TRP A 1 100 ? 2.747   24.758  -2.076  1.000 58.208  ? 100 TRP A CZ2   1 ? 
ATOM   780  C  CZ3   . TRP A 1 100 ? 1.654   23.304  -0.479  1.000 55.842  ? 100 TRP A CZ3   1 ? 
ATOM   781  C  CH2   . TRP A 1 100 ? 1.693   23.943  -1.720  1.000 54.318  ? 100 TRP A CH2   1 ? 
ATOM   782  N  N     . ILE A 1 101 ? 7.247   22.600  4.040   1.000 60.107  ? 101 ILE A N     1 ? 
ATOM   783  C  CA    . ILE A 1 101 ? 7.306   21.821  5.319   1.000 59.489  ? 101 ILE A CA    1 ? 
ATOM   784  C  C     . ILE A 1 101 ? 8.591   22.180  6.083   1.000 61.863  ? 101 ILE A C     1 ? 
ATOM   785  O  O     . ILE A 1 101 ? 8.521   22.270  7.326   1.000 67.586  ? 101 ILE A O     1 ? 
ATOM   786  C  CB    . ILE A 1 101 ? 7.206   20.291  5.090   1.000 57.508  ? 101 ILE A CB    1 ? 
ATOM   787  C  CG1   . ILE A 1 101 ? 6.257   19.901  3.951   1.000 58.633  ? 101 ILE A CG1   1 ? 
ATOM   788  C  CG2   . ILE A 1 101 ? 6.835   19.588  6.385   1.000 53.502  ? 101 ILE A CG2   1 ? 
ATOM   789  C  CD1   . ILE A 1 101 ? 4.822   20.331  4.154   1.000 59.885  ? 101 ILE A CD1   1 ? 
ATOM   790  N  N     . ARG A 1 102 ? 9.723   22.348  5.382   1.000 65.681  ? 102 ARG A N     1 ? 
ATOM   791  C  CA    . ARG A 1 102 ? 11.062  22.558  6.009   1.000 64.252  ? 102 ARG A CA    1 ? 
ATOM   792  C  C     . ARG A 1 102 ? 11.090  23.897  6.736   1.000 62.016  ? 102 ARG A C     1 ? 
ATOM   793  O  O     . ARG A 1 102 ? 11.488  23.931  7.921   1.000 49.132  ? 102 ARG A O     1 ? 
ATOM   794  C  CB    . ARG A 1 102 ? 12.193  22.571  4.980   1.000 68.277  ? 102 ARG A CB    1 ? 
ATOM   795  C  CG    . ARG A 1 102 ? 13.573  22.690  5.622   1.000 70.213  ? 102 ARG A CG    1 ? 
ATOM   796  C  CD    . ARG A 1 102 ? 14.663  23.214  4.708   1.000 67.982  ? 102 ARG A CD    1 ? 
ATOM   797  N  NE    . ARG A 1 102 ? 14.162  24.280  3.856   1.000 68.300  ? 102 ARG A NE    1 ? 
ATOM   798  C  CZ    . ARG A 1 102 ? 14.227  24.292  2.530   1.000 67.579  ? 102 ARG A CZ    1 ? 
ATOM   799  N  NH1   . ARG A 1 102 ? 13.721  25.313  1.855   1.000 66.012  ? 102 ARG A NH1   1 ? 
ATOM   800  N  NH2   . ARG A 1 102 ? 14.813  23.302  1.883   1.000 63.259  ? 102 ARG A NH2   1 ? 
ATOM   801  N  N     . ASP A 1 103 ? 10.749  24.958  6.011   1.000 67.805  ? 103 ASP A N     1 ? 
ATOM   802  C  CA    . ASP A 1 103 ? 10.756  26.353  6.515   1.000 71.909  ? 103 ASP A CA    1 ? 
ATOM   803  C  C     . ASP A 1 103 ? 9.850   26.417  7.746   1.000 70.690  ? 103 ASP A C     1 ? 
ATOM   804  O  O     . ASP A 1 103 ? 10.290  26.972  8.766   1.000 70.887  ? 103 ASP A O     1 ? 
ATOM   805  C  CB    . ASP A 1 103 ? 10.349  27.314  5.399   1.000 70.343  ? 103 ASP A CB    1 ? 
ATOM   806  C  CG    . ASP A 1 103 ? 11.172  27.095  4.145   1.000 73.860  ? 103 ASP A CG    1 ? 
ATOM   807  O  OD1   . ASP A 1 103 ? 10.577  27.049  3.051   1.000 81.147  ? 103 ASP A OD1   1 ? 
ATOM   808  O  OD2   . ASP A 1 103 ? 12.398  26.929  4.280   1.000 73.516  ? 103 ASP A OD2   1 ? 
ATOM   809  N  N     . ALA A 1 104 ? 8.667   25.800  7.657   1.000 69.381  ? 104 ALA A N     1 ? 
ATOM   810  C  CA    . ALA A 1 104 ? 7.697   25.641  8.763   1.000 72.010  ? 104 ALA A CA    1 ? 
ATOM   811  C  C     . ALA A 1 104 ? 8.406   25.097  10.013  1.000 71.589  ? 104 ALA A C     1 ? 
ATOM   812  O  O     . ALA A 1 104 ? 8.141   25.623  11.124  1.000 68.673  ? 104 ALA A O     1 ? 
ATOM   813  C  CB    . ALA A 1 104 ? 6.570   24.737  8.326   1.000 75.856  ? 104 ALA A CB    1 ? 
ATOM   814  N  N     . LEU A 1 105 ? 9.290   24.107  9.837   1.000 70.747  ? 105 LEU A N     1 ? 
ATOM   815  C  CA    . LEU A 1 105 ? 9.981   23.377  10.940  1.000 71.829  ? 105 LEU A CA    1 ? 
ATOM   816  C  C     . LEU A 1 105 ? 11.433  23.858  11.096  1.000 73.908  ? 105 LEU A C     1 ? 
ATOM   817  O  O     . LEU A 1 105 ? 12.131  23.324  11.979  1.000 72.327  ? 105 LEU A O     1 ? 
ATOM   818  C  CB    . LEU A 1 105 ? 9.938   21.876  10.640  1.000 72.315  ? 105 LEU A CB    1 ? 
ATOM   819  C  CG    . LEU A 1 105 ? 8.545   21.257  10.558  1.000 70.825  ? 105 LEU A CG    1 ? 
ATOM   820  C  CD1   . LEU A 1 105 ? 8.604   19.913  9.851   1.000 70.174  ? 105 LEU A CD1   1 ? 
ATOM   821  C  CD2   . LEU A 1 105 ? 7.927   21.116  11.943  1.000 69.943  ? 105 LEU A CD2   1 ? 
ATOM   822  N  N     . LYS A 1 106 ? 11.875  24.807  10.265  1.000 77.444  ? 106 LYS A N     1 ? 
ATOM   823  C  CA    . LYS A 1 106 ? 13.172  25.527  10.411  1.000 79.293  ? 106 LYS A CA    1 ? 
ATOM   824  C  C     . LYS A 1 106 ? 13.541  25.642  11.903  1.000 77.588  ? 106 LYS A C     1 ? 
ATOM   825  O  O     . LYS A 1 106 ? 14.496  24.953  12.333  1.000 73.135  ? 106 LYS A O     1 ? 
ATOM   826  C  CB    . LYS A 1 106 ? 13.066  26.901  9.739   1.000 78.980  ? 106 LYS A CB    1 ? 
ATOM   827  C  CG    . LYS A 1 106 ? 14.034  27.965  10.245  1.000 81.013  ? 106 LYS A CG    1 ? 
ATOM   828  C  CD    . LYS A 1 106 ? 13.627  29.384  9.887   1.000 78.468  ? 106 LYS A CD    1 ? 
ATOM   829  C  CE    . LYS A 1 106 ? 14.038  30.393  10.938  1.000 77.918  ? 106 LYS A CE    1 ? 
ATOM   830  N  NZ    . LYS A 1 106 ? 13.898  31.782  10.448  1.000 80.463  ? 106 LYS A NZ    1 ? 
ATOM   831  N  N     . ASP A 1 107 ? 12.788  26.448  12.666  1.000 79.017  ? 107 ASP A N     1 ? 
ATOM   832  C  CA    . ASP A 1 107 ? 13.099  26.821  14.077  1.000 84.675  ? 107 ASP A CA    1 ? 
ATOM   833  C  C     . ASP A 1 107 ? 12.883  25.592  14.971  1.000 86.968  ? 107 ASP A C     1 ? 
ATOM   834  O  O     . ASP A 1 107 ? 13.114  25.701  16.192  1.000 88.325  ? 107 ASP A O     1 ? 
ATOM   835  C  CB    . ASP A 1 107 ? 12.264  28.030  14.535  1.000 83.985  ? 107 ASP A CB    1 ? 
ATOM   836  C  CG    . ASP A 1 107 ? 13.006  29.058  15.393  1.000 82.067  ? 107 ASP A CG    1 ? 
ATOM   837  O  OD1   . ASP A 1 107 ? 13.674  28.652  16.370  1.000 75.653  ? 107 ASP A OD1   1 ? 
ATOM   838  O  OD2   . ASP A 1 107 ? 12.873  30.270  15.103  1.000 76.875  ? 107 ASP A OD2   1 ? 
ATOM   839  N  N     . TYR A 1 108 ? 12.463  24.465  14.384  1.000 90.883  ? 108 TYR A N     1 ? 
ATOM   840  C  CA    . TYR A 1 108 ? 12.236  23.178  15.091  1.000 89.980  ? 108 TYR A CA    1 ? 
ATOM   841  C  C     . TYR A 1 108 ? 13.572  22.445  15.268  1.000 88.562  ? 108 TYR A C     1 ? 
ATOM   842  O  O     . TYR A 1 108 ? 14.355  22.355  14.284  1.000 77.859  ? 108 TYR A O     1 ? 
ATOM   843  C  CB    . TYR A 1 108 ? 11.208  22.312  14.354  1.000 87.275  ? 108 TYR A CB    1 ? 
ATOM   844  C  CG    . TYR A 1 108 ? 10.525  21.299  15.235  1.000 84.919  ? 108 TYR A CG    1 ? 
ATOM   845  C  CD1   . TYR A 1 108 ? 9.478   21.667  16.063  1.000 81.611  ? 108 TYR A CD1   1 ? 
ATOM   846  C  CD2   . TYR A 1 108 ? 10.950  19.981  15.275  1.000 82.538  ? 108 TYR A CD2   1 ? 
ATOM   847  C  CE1   . TYR A 1 108 ? 8.857   20.749  16.893  1.000 79.420  ? 108 TYR A CE1   1 ? 
ATOM   848  C  CE2   . TYR A 1 108 ? 10.343  19.051  16.103  1.000 79.206  ? 108 TYR A CE2   1 ? 
ATOM   849  C  CZ    . TYR A 1 108 ? 9.294   19.437  16.916  1.000 78.230  ? 108 TYR A CZ    1 ? 
ATOM   850  O  OH    . TYR A 1 108 ? 8.694   18.525  17.731  1.000 79.175  ? 108 TYR A OH    1 ? 
ATOM   851  N  N     . GLY A 1 109 ? 13.821  21.976  16.501  1.000 89.623  ? 109 GLY A N     1 ? 
ATOM   852  C  CA    . GLY A 1 109 ? 14.933  21.082  16.884  1.000 86.430  ? 109 GLY A CA    1 ? 
ATOM   853  C  C     . GLY A 1 109 ? 16.266  21.564  16.341  1.000 81.407  ? 109 GLY A C     1 ? 
ATOM   854  O  O     . GLY A 1 109 ? 16.647  22.719  16.657  1.000 72.971  ? 109 GLY A O     1 ? 
ATOM   855  N  N     . ASN A 1 110 ? 16.933  20.720  15.540  1.000 73.095  ? 110 ASN A N     1 ? 
ATOM   856  C  CA    . ASN A 1 110 ? 18.236  21.016  14.880  1.000 74.740  ? 110 ASN A CA    1 ? 
ATOM   857  C  C     . ASN A 1 110 ? 18.006  21.275  13.387  1.000 68.615  ? 110 ASN A C     1 ? 
ATOM   858  O  O     . ASN A 1 110 ? 18.983  21.173  12.623  1.000 67.186  ? 110 ASN A O     1 ? 
ATOM   859  C  CB    . ASN A 1 110 ? 19.261  19.887  15.045  1.000 75.931  ? 110 ASN A CB    1 ? 
ATOM   860  C  CG    . ASN A 1 110 ? 19.169  19.162  16.370  1.000 80.298  ? 110 ASN A CG    1 ? 
ATOM   861  O  OD1   . ASN A 1 110 ? 19.291  17.935  16.419  1.000 80.950  ? 110 ASN A OD1   1 ? 
ATOM   862  N  ND2   . ASN A 1 110 ? 18.968  19.909  17.447  1.000 74.291  ? 110 ASN A ND2   1 ? 
ATOM   863  N  N     . GLY A 1 111 ? 16.766  21.592  12.999  1.000 63.841  ? 111 GLY A N     1 ? 
ATOM   864  C  CA    . GLY A 1 111 ? 16.394  21.973  11.626  1.000 60.338  ? 111 GLY A CA    1 ? 
ATOM   865  C  C     . GLY A 1 111 ? 15.915  20.786  10.820  1.000 54.526  ? 111 GLY A C     1 ? 
ATOM   866  O  O     . GLY A 1 111 ? 15.753  19.709  11.403  1.000 58.436  ? 111 GLY A O     1 ? 
ATOM   867  N  N     . ALA A 1 112 ? 15.725  20.982  9.517   1.000 52.285  ? 112 ALA A N     1 ? 
ATOM   868  C  CA    . ALA A 1 112 ? 14.955  20.091  8.623   1.000 55.499  ? 112 ALA A CA    1 ? 
ATOM   869  C  C     . ALA A 1 112 ? 15.594  20.055  7.230   1.000 54.662  ? 112 ALA A C     1 ? 
ATOM   870  O  O     . ALA A 1 112 ? 15.941  21.125  6.708   1.000 58.585  ? 112 ALA A O     1 ? 
ATOM   871  C  CB    . ALA A 1 112 ? 13.527  20.568  8.554   1.000 57.002  ? 112 ALA A CB    1 ? 
ATOM   872  N  N     . GLU A 1 113 ? 15.679  18.861  6.641   1.000 53.638  ? 113 GLU A N     1 ? 
ATOM   873  C  CA    . GLU A 1 113 ? 16.331  18.584  5.338   1.000 50.422  ? 113 GLU A CA    1 ? 
ATOM   874  C  C     . GLU A 1 113 ? 15.280  17.990  4.401   1.000 46.957  ? 113 GLU A C     1 ? 
ATOM   875  O  O     . GLU A 1 113 ? 14.445  17.201  4.893   1.000 44.588  ? 113 GLU A O     1 ? 
ATOM   876  C  CB    . GLU A 1 113 ? 17.509  17.632  5.578   1.000 56.962  ? 113 GLU A CB    1 ? 
ATOM   877  C  CG    . GLU A 1 113 ? 18.199  17.125  4.315   1.000 61.830  ? 113 GLU A CG    1 ? 
ATOM   878  C  CD    . GLU A 1 113 ? 19.116  15.926  4.532   1.000 66.185  ? 113 GLU A CD    1 ? 
ATOM   879  O  OE1   . GLU A 1 113 ? 19.371  15.192  3.548   1.000 68.591  ? 113 GLU A OE1   1 ? 
ATOM   880  O  OE2   . GLU A 1 113 ? 19.563  15.714  5.684   1.000 67.839  ? 113 GLU A OE2   1 ? 
ATOM   881  N  N     . ILE A 1 114 ? 15.314  18.338  3.111   1.000 43.079  ? 114 ILE A N     1 ? 
ATOM   882  C  CA    . ILE A 1 114 ? 14.435  17.712  2.080   1.000 43.538  ? 114 ILE A CA    1 ? 
ATOM   883  C  C     . ILE A 1 114 ? 15.135  16.484  1.508   1.000 45.808  ? 114 ILE A C     1 ? 
ATOM   884  O  O     . ILE A 1 114 ? 16.220  16.648  0.928   1.000 46.360  ? 114 ILE A O     1 ? 
ATOM   885  C  CB    . ILE A 1 114 ? 14.024  18.692  0.967   1.000 45.195  ? 114 ILE A CB    1 ? 
ATOM   886  C  CG1   . ILE A 1 114 ? 13.066  19.765  1.498   1.000 45.473  ? 114 ILE A CG1   1 ? 
ATOM   887  C  CG2   . ILE A 1 114 ? 13.428  17.927  -0.207  1.000 41.913  ? 114 ILE A CG2   1 ? 
ATOM   888  C  CD1   . ILE A 1 114 ? 12.748  20.878  0.525   1.000 44.576  ? 114 ILE A CD1   1 ? 
ATOM   889  N  N     . ARG A 1 115 ? 14.483  15.316  1.637   1.000 48.107  ? 115 ARG A N     1 ? 
ATOM   890  C  CA    . ARG A 1 115 ? 14.914  14.009  1.080   1.000 42.813  ? 115 ARG A CA    1 ? 
ATOM   891  C  C     . ARG A 1 115 ? 13.984  13.627  -0.073  1.000 41.318  ? 115 ARG A C     1 ? 
ATOM   892  O  O     . ARG A 1 115 ? 12.909  14.224  -0.189  1.000 42.306  ? 115 ARG A O     1 ? 
ATOM   893  C  CB    . ARG A 1 115 ? 14.922  12.948  2.181   1.000 43.018  ? 115 ARG A CB    1 ? 
ATOM   894  C  CG    . ARG A 1 115 ? 15.826  13.293  3.353   1.000 46.398  ? 115 ARG A CG    1 ? 
ATOM   895  C  CD    . ARG A 1 115 ? 16.809  12.176  3.636   1.000 54.157  ? 115 ARG A CD    1 ? 
ATOM   896  N  NE    . ARG A 1 115 ? 17.538  12.346  4.894   1.000 60.761  ? 115 ARG A NE    1 ? 
ATOM   897  C  CZ    . ARG A 1 115 ? 17.356  11.624  6.004   1.000 64.972  ? 115 ARG A CZ    1 ? 
ATOM   898  N  NH1   . ARG A 1 115 ? 16.446  10.659  6.047   1.000 65.478  ? 115 ARG A NH1   1 ? 
ATOM   899  N  NH2   . ARG A 1 115 ? 18.097  11.877  7.074   1.000 66.088  ? 115 ARG A NH2   1 ? 
ATOM   900  N  N     . ARG A 1 116 ? 14.406  12.647  -0.871  1.000 40.428  ? 116 ARG A N     1 ? 
ATOM   901  C  CA    . ARG A 1 116 ? 13.776  12.193  -2.143  1.000 41.504  ? 116 ARG A CA    1 ? 
ATOM   902  C  C     . ARG A 1 116 ? 12.296  11.844  -1.929  1.000 35.870  ? 116 ARG A C     1 ? 
ATOM   903  O  O     . ARG A 1 116 ? 11.502  12.012  -2.877  1.000 34.116  ? 116 ARG A O     1 ? 
ATOM   904  C  CB    . ARG A 1 116 ? 14.533  10.968  -2.680  1.000 44.151  ? 116 ARG A CB    1 ? 
ATOM   905  C  CG    . ARG A 1 116 ? 13.818  10.201  -3.788  1.000 53.370  ? 116 ARG A CG    1 ? 
ATOM   906  C  CD    . ARG A 1 116 ? 14.731  9.224   -4.525  1.000 62.460  ? 116 ARG A CD    1 ? 
ATOM   907  N  NE    . ARG A 1 116 ? 15.106  9.707   -5.855  1.000 72.451  ? 116 ARG A NE    1 ? 
ATOM   908  C  CZ    . ARG A 1 116 ? 16.154  10.493  -6.137  1.000 76.275  ? 116 ARG A CZ    1 ? 
ATOM   909  N  NH1   . ARG A 1 116 ? 16.982  10.893  -5.184  1.000 76.097  ? 116 ARG A NH1   1 ? 
ATOM   910  N  NH2   . ARG A 1 116 ? 16.372  10.875  -7.388  1.000 73.428  ? 116 ARG A NH2   1 ? 
ATOM   911  N  N     . SER A 1 117 ? 11.959  11.309  -0.764  1.000 29.084  ? 117 SER A N     1 ? 
ATOM   912  C  CA    . SER A 1 117 ? 10.663  10.653  -0.504  1.000 32.192  ? 117 SER A CA    1 ? 
ATOM   913  C  C     . SER A 1 117 ? 10.025  11.223  0.752   1.000 34.016  ? 117 SER A C     1 ? 
ATOM   914  O  O     . SER A 1 117 ? 8.946   10.736  1.121   1.000 38.971  ? 117 SER A O     1 ? 
ATOM   915  C  CB    . SER A 1 117 ? 10.836  9.183   -0.390  1.000 29.742  ? 117 SER A CB    1 ? 
ATOM   916  O  OG    . SER A 1 117 ? 11.177  8.642   -1.638  1.000 29.415  ? 117 SER A OG    1 ? 
ATOM   917  N  N     . CYS A 1 118 ? 10.668  12.199  1.382   1.000 36.287  ? 118 CYS A N     1 ? 
ATOM   918  C  CA    . CYS A 1 118 ? 10.154  12.850  2.605   1.000 35.383  ? 118 CYS A CA    1 ? 
ATOM   919  C  C     . CYS A 1 118 ? 10.999  14.064  2.969   1.000 32.913  ? 118 CYS A C     1 ? 
ATOM   920  O  O     . CYS A 1 118 ? 12.126  14.149  2.495   1.000 32.641  ? 118 CYS A O     1 ? 
ATOM   921  C  CB    . CYS A 1 118 ? 10.176  11.879  3.776   1.000 34.346  ? 118 CYS A CB    1 ? 
ATOM   922  S  SG    . CYS A 1 118 ? 11.847  11.456  4.312   1.000 33.258  ? 118 CYS A SG    1 ? 
ATOM   923  N  N     . VAL A 1 119 ? 10.432  14.937  3.798   1.000 34.881  ? 119 VAL A N     1 ? 
ATOM   924  C  CA    . VAL A 1 119 ? 11.139  15.936  4.648   1.000 38.122  ? 119 VAL A CA    1 ? 
ATOM   925  C  C     . VAL A 1 119 ? 11.514  15.242  5.949   1.000 39.288  ? 119 VAL A C     1 ? 
ATOM   926  O  O     . VAL A 1 119 ? 10.581  14.831  6.670   1.000 41.086  ? 119 VAL A O     1 ? 
ATOM   927  C  CB    . VAL A 1 119 ? 10.257  17.170  4.934   1.000 38.468  ? 119 VAL A CB    1 ? 
ATOM   928  C  CG1   . VAL A 1 119 ? 10.826  18.045  6.041   1.000 37.735  ? 119 VAL A CG1   1 ? 
ATOM   929  C  CG2   . VAL A 1 119 ? 10.000  17.985  3.683   1.000 39.103  ? 119 VAL A CG2   1 ? 
ATOM   930  N  N     . THR A 1 120 ? 12.816  15.131  6.237   1.000 41.719  ? 120 THR A N     1 ? 
ATOM   931  C  CA    . THR A 1 120 ? 13.349  14.740  7.569   1.000 45.890  ? 120 THR A CA    1 ? 
ATOM   932  C  C     . THR A 1 120 ? 13.553  15.993  8.421   1.000 47.585  ? 120 THR A C     1 ? 
ATOM   933  O  O     . THR A 1 120 ? 13.915  17.031  7.858   1.000 58.208  ? 120 THR A O     1 ? 
ATOM   934  C  CB    . THR A 1 120 ? 14.657  13.944  7.475   1.000 44.050  ? 120 THR A CB    1 ? 
ATOM   935  O  OG1   . THR A 1 120 ? 14.471  12.818  6.613   1.000 45.303  ? 120 THR A OG1   1 ? 
ATOM   936  C  CG2   . THR A 1 120 ? 15.126  13.464  8.830   1.000 40.158  ? 120 THR A CG2   1 ? 
ATOM   937  N  N     . VAL A 1 121 ? 13.297  15.880  9.724   1.000 52.703  ? 121 VAL A N     1 ? 
ATOM   938  C  CA    . VAL A 1 121 ? 13.531  16.939  10.747  1.000 57.555  ? 121 VAL A CA    1 ? 
ATOM   939  C  C     . VAL A 1 121 ? 14.097  16.242  11.988  1.000 63.800  ? 121 VAL A C     1 ? 
ATOM   940  O  O     . VAL A 1 121 ? 13.749  15.054  12.208  1.000 60.579  ? 121 VAL A O     1 ? 
ATOM   941  C  CB    . VAL A 1 121 ? 12.244  17.732  11.050  1.000 58.810  ? 121 VAL A CB    1 ? 
ATOM   942  C  CG1   . VAL A 1 121 ? 11.083  16.818  11.419  1.000 60.789  ? 121 VAL A CG1   1 ? 
ATOM   943  C  CG2   . VAL A 1 121 ? 12.455  18.786  12.130  1.000 59.925  ? 121 VAL A CG2   1 ? 
ATOM   944  N  N     . PHE A 1 122 ? 14.950  16.940  12.747  1.000 65.044  ? 122 PHE A N     1 ? 
ATOM   945  C  CA    . PHE A 1 122 ? 15.839  16.357  13.788  1.000 63.099  ? 122 PHE A CA    1 ? 
ATOM   946  C  C     . PHE A 1 122 ? 15.442  16.873  15.180  1.000 66.579  ? 122 PHE A C     1 ? 
ATOM   947  O  O     . PHE A 1 122 ? 14.598  17.791  15.296  1.000 68.695  ? 122 PHE A O     1 ? 
ATOM   948  C  CB    . PHE A 1 122 ? 17.295  16.638  13.411  1.000 56.420  ? 122 PHE A CB    1 ? 
ATOM   949  C  CG    . PHE A 1 122 ? 17.631  16.237  11.997  1.000 51.644  ? 122 PHE A CG    1 ? 
ATOM   950  C  CD1   . PHE A 1 122 ? 18.208  15.006  11.723  1.000 50.039  ? 122 PHE A CD1   1 ? 
ATOM   951  C  CD2   . PHE A 1 122 ? 17.325  17.069  10.933  1.000 52.899  ? 122 PHE A CD2   1 ? 
ATOM   952  C  CE1   . PHE A 1 122 ? 18.493  14.631  10.418  1.000 47.619  ? 122 PHE A CE1   1 ? 
ATOM   953  C  CE2   . PHE A 1 122 ? 17.606  16.689  9.629   1.000 50.986  ? 122 PHE A CE2   1 ? 
ATOM   954  C  CZ    . PHE A 1 122 ? 18.191  15.473  9.373   1.000 47.755  ? 122 PHE A CZ    1 ? 
ATOM   955  N  N     . LYS A 1 123 ? 16.013  16.258  16.218  1.000 75.352  ? 123 LYS A N     1 ? 
ATOM   956  C  CA    . LYS A 1 123 ? 15.730  16.562  17.648  1.000 80.156  ? 123 LYS A CA    1 ? 
ATOM   957  C  C     . LYS A 1 123 ? 16.604  15.678  18.536  1.000 76.098  ? 123 LYS A C     1 ? 
ATOM   958  O  O     . LYS A 1 123 ? 17.391  14.871  18.042  1.000 69.348  ? 123 LYS A O     1 ? 
ATOM   959  C  CB    . LYS A 1 123 ? 14.237  16.377  17.951  1.000 85.788  ? 123 LYS A CB    1 ? 
ATOM   960  C  CG    . LYS A 1 123 ? 13.473  17.662  18.254  1.000 94.633  ? 123 LYS A CG    1 ? 
ATOM   961  C  CD    . LYS A 1 123 ? 12.306  17.466  19.204  1.000 97.386  ? 123 LYS A CD    1 ? 
ATOM   962  C  CE    . LYS A 1 123 ? 11.655  18.760  19.641  1.000 99.077  ? 123 LYS A CE    1 ? 
ATOM   963  N  NZ    . LYS A 1 123 ? 10.426  18.511  20.432  1.000 101.571 ? 123 LYS A NZ    1 ? 
ATOM   964  N  N     . PRO A 1 124 ? 16.534  15.840  19.876  1.000 78.021  ? 124 PRO A N     1 ? 
ATOM   965  C  CA    . PRO A 1 124 ? 17.341  15.027  20.783  1.000 77.219  ? 124 PRO A CA    1 ? 
ATOM   966  C  C     . PRO A 1 124 ? 17.056  13.522  20.623  1.000 72.584  ? 124 PRO A C     1 ? 
ATOM   967  O  O     . PRO A 1 124 ? 16.000  13.065  21.045  1.000 67.777  ? 124 PRO A O     1 ? 
ATOM   968  C  CB    . PRO A 1 124 ? 16.945  15.544  22.183  1.000 81.376  ? 124 PRO A CB    1 ? 
ATOM   969  C  CG    . PRO A 1 124 ? 16.395  16.943  21.938  1.000 80.269  ? 124 PRO A CG    1 ? 
ATOM   970  C  CD    . PRO A 1 124 ? 15.729  16.853  20.584  1.000 81.393  ? 124 PRO A CD    1 ? 
ATOM   971  N  N     . GLY A 1 125 ? 17.978  12.799  19.980  1.000 66.449  ? 125 GLY A N     1 ? 
ATOM   972  C  CA    . GLY A 1 125 ? 18.001  11.319  19.952  1.000 64.795  ? 125 GLY A CA    1 ? 
ATOM   973  C  C     . GLY A 1 125 ? 16.906  10.707  19.078  1.000 58.216  ? 125 GLY A C     1 ? 
ATOM   974  O  O     . GLY A 1 125 ? 16.624  9.498   19.244  1.000 46.680  ? 125 GLY A O     1 ? 
ATOM   975  N  N     . TYR A 1 126 ? 16.320  11.486  18.162  1.000 52.778  ? 126 TYR A N     1 ? 
ATOM   976  C  CA    . TYR A 1 126 ? 15.402  10.968  17.125  1.000 51.758  ? 126 TYR A CA    1 ? 
ATOM   977  C  C     . TYR A 1 126 ? 15.290  11.949  15.971  1.000 48.817  ? 126 TYR A C     1 ? 
ATOM   978  O  O     . TYR A 1 126 ? 15.864  13.028  16.040  1.000 54.254  ? 126 TYR A O     1 ? 
ATOM   979  C  CB    . TYR A 1 126 ? 14.029  10.673  17.720  1.000 57.887  ? 126 TYR A CB    1 ? 
ATOM   980  C  CG    . TYR A 1 126 ? 13.326  11.826  18.384  1.000 60.586  ? 126 TYR A CG    1 ? 
ATOM   981  C  CD1   . TYR A 1 126 ? 13.374  11.983  19.760  1.000 65.219  ? 126 TYR A CD1   1 ? 
ATOM   982  C  CD2   . TYR A 1 126 ? 12.539  12.705  17.656  1.000 64.580  ? 126 TYR A CD2   1 ? 
ATOM   983  C  CE1   . TYR A 1 126 ? 12.697  13.014  20.394  1.000 65.674  ? 126 TYR A CE1   1 ? 
ATOM   984  C  CE2   . TYR A 1 126 ? 11.849  13.740  18.275  1.000 67.205  ? 126 TYR A CE2   1 ? 
ATOM   985  C  CZ    . TYR A 1 126 ? 11.933  13.896  19.649  1.000 65.099  ? 126 TYR A CZ    1 ? 
ATOM   986  O  OH    . TYR A 1 126 ? 11.260  14.903  20.273  1.000 67.098  ? 126 TYR A OH    1 ? 
ATOM   987  N  N     . HIS A 1 127 ? 14.583  11.532  14.927  1.000 44.893  ? 127 HIS A N     1 ? 
ATOM   988  C  CA    . HIS A 1 127 ? 14.197  12.358  13.758  1.000 41.634  ? 127 HIS A CA    1 ? 
ATOM   989  C  C     . HIS A 1 127 ? 12.776  11.965  13.340  1.000 40.574  ? 127 HIS A C     1 ? 
ATOM   990  O  O     . HIS A 1 127 ? 12.356  10.837  13.666  1.000 35.618  ? 127 HIS A O     1 ? 
ATOM   991  C  CB    . HIS A 1 127 ? 15.231  12.195  12.639  1.000 41.909  ? 127 HIS A CB    1 ? 
ATOM   992  C  CG    . HIS A 1 127 ? 15.353  10.810  12.097  1.000 45.025  ? 127 HIS A CG    1 ? 
ATOM   993  N  ND1   . HIS A 1 127 ? 16.265  9.905   12.586  1.000 45.210  ? 127 HIS A ND1   1 ? 
ATOM   994  C  CD2   . HIS A 1 127 ? 14.711  10.184  11.082  1.000 49.153  ? 127 HIS A CD2   1 ? 
ATOM   995  C  CE1   . HIS A 1 127 ? 16.170  8.775   11.913  1.000 49.935  ? 127 HIS A CE1   1 ? 
ATOM   996  N  NE2   . HIS A 1 127 ? 15.220  8.916   10.984  1.000 44.775  ? 127 HIS A NE2   1 ? 
ATOM   997  N  N     . VAL A 1 128 ? 12.051  12.862  12.672  1.000 41.114  ? 128 VAL A N     1 ? 
ATOM   998  C  CA    . VAL A 1 128 ? 10.742  12.541  12.034  1.000 40.947  ? 128 VAL A CA    1 ? 
ATOM   999  C  C     . VAL A 1 128 ? 10.946  12.627  10.526  1.000 37.980  ? 128 VAL A C     1 ? 
ATOM   1000 O  O     . VAL A 1 128 ? 11.451  13.654  10.079  1.000 37.451  ? 128 VAL A O     1 ? 
ATOM   1001 C  CB    . VAL A 1 128 ? 9.604   13.471  12.517  1.000 39.890  ? 128 VAL A CB    1 ? 
ATOM   1002 C  CG1   . VAL A 1 128 ? 8.313   13.266  11.737  1.000 43.034  ? 128 VAL A CG1   1 ? 
ATOM   1003 C  CG2   . VAL A 1 128 ? 9.335   13.314  13.995  1.000 37.649  ? 128 VAL A CG2   1 ? 
ATOM   1004 N  N     . ASP A 1 129 ? 10.588  11.568  9.793   1.000 36.113  ? 129 ASP A N     1 ? 
ATOM   1005 C  CA    . ASP A 1 129 ? 10.398  11.612  8.322   1.000 34.345  ? 129 ASP A CA    1 ? 
ATOM   1006 C  C     . ASP A 1 129 ? 8.911   11.857  8.043   1.000 32.812  ? 129 ASP A C     1 ? 
ATOM   1007 O  O     . ASP A 1 129 ? 8.100   11.062  8.508   1.000 31.591  ? 129 ASP A O     1 ? 
ATOM   1008 C  CB    . ASP A 1 129 ? 10.907  10.338  7.642   1.000 35.417  ? 129 ASP A CB    1 ? 
ATOM   1009 C  CG    . ASP A 1 129 ? 12.413  10.073  7.768   1.000 37.698  ? 129 ASP A CG    1 ? 
ATOM   1010 O  OD1   . ASP A 1 129 ? 13.217  11.029  7.628   1.000 36.899  ? 129 ASP A OD1   1 ? 
ATOM   1011 O  OD2   . ASP A 1 129 ? 12.778  8.894   7.952   1.000 38.480  ? 129 ASP A OD2   1 ? 
ATOM   1012 N  N     . LEU A 1 130 ? 8.587   12.940  7.319   1.000 32.216  ? 130 LEU A N     1 ? 
ATOM   1013 C  CA    . LEU A 1 130 ? 7.212   13.332  6.905   1.000 30.834  ? 130 LEU A CA    1 ? 
ATOM   1014 C  C     . LEU A 1 130 ? 7.074   13.152  5.403   1.000 28.113  ? 130 LEU A C     1 ? 
ATOM   1015 O  O     . LEU A 1 130 ? 7.547   14.030  4.667   1.000 27.150  ? 130 LEU A O     1 ? 
ATOM   1016 C  CB    . LEU A 1 130 ? 6.938   14.795  7.261   1.000 33.220  ? 130 LEU A CB    1 ? 
ATOM   1017 C  CG    . LEU A 1 130 ? 7.107   15.143  8.729   1.000 32.708  ? 130 LEU A CG    1 ? 
ATOM   1018 C  CD1   . LEU A 1 130 ? 8.528   15.611  8.986   1.000 35.027  ? 130 LEU A CD1   1 ? 
ATOM   1019 C  CD2   . LEU A 1 130 ? 6.102   16.202  9.152   1.000 34.237  ? 130 LEU A CD2   1 ? 
ATOM   1020 N  N     . ALA A 1 131 ? 6.442   12.059  4.983   1.000 26.073  ? 131 ALA A N     1 ? 
ATOM   1021 C  CA    . ALA A 1 131 ? 5.993   11.853  3.602   1.000 24.892  ? 131 ALA A CA    1 ? 
ATOM   1022 C  C     . ALA A 1 131 ? 4.824   12.808  3.358   1.000 27.287  ? 131 ALA A C     1 ? 
ATOM   1023 O  O     . ALA A 1 131 ? 3.990   12.999  4.285   1.000 24.959  ? 131 ALA A O     1 ? 
ATOM   1024 C  CB    . ALA A 1 131 ? 5.624   10.419  3.371   1.000 26.751  ? 131 ALA A CB    1 ? 
ATOM   1025 N  N     . VAL A 1 132 ? 4.850   13.462  2.197   1.000 29.642  ? 132 VAL A N     1 ? 
ATOM   1026 C  CA    . VAL A 1 132 ? 3.964   14.599  1.813   1.000 29.543  ? 132 VAL A CA    1 ? 
ATOM   1027 C  C     . VAL A 1 132 ? 3.193   14.140  0.588   1.000 25.999  ? 132 VAL A C     1 ? 
ATOM   1028 O  O     . VAL A 1 132 ? 3.845   13.822  -0.399  1.000 26.937  ? 132 VAL A O     1 ? 
ATOM   1029 C  CB    . VAL A 1 132 ? 4.785   15.871  1.512   1.000 29.748  ? 132 VAL A CB    1 ? 
ATOM   1030 C  CG1   . VAL A 1 132 ? 3.897   17.060  1.136   1.000 29.389  ? 132 VAL A CG1   1 ? 
ATOM   1031 C  CG2   . VAL A 1 132 ? 5.705   16.225  2.671   1.000 28.561  ? 132 VAL A CG2   1 ? 
ATOM   1032 N  N     . TYR A 1 133 ? 1.865   14.079  0.666   1.000 26.144  ? 133 TYR A N     1 ? 
ATOM   1033 C  CA    . TYR A 1 133 ? 1.025   13.569  -0.449  1.000 27.470  ? 133 TYR A CA    1 ? 
ATOM   1034 C  C     . TYR A 1 133 ? 0.100   14.678  -0.998  1.000 23.891  ? 133 TYR A C     1 ? 
ATOM   1035 O  O     . TYR A 1 133 ? -0.380  15.493  -0.245  1.000 21.598  ? 133 TYR A O     1 ? 
ATOM   1036 C  CB    . TYR A 1 133 ? 0.240   12.332  0.021   1.000 28.466  ? 133 TYR A CB    1 ? 
ATOM   1037 C  CG    . TYR A 1 133 ? 1.079   11.214  0.608   1.000 27.136  ? 133 TYR A CG    1 ? 
ATOM   1038 C  CD1   . TYR A 1 133 ? 1.472   11.230  1.942   1.000 26.935  ? 133 TYR A CD1   1 ? 
ATOM   1039 C  CD2   . TYR A 1 133 ? 1.430   10.116  -0.152  1.000 24.861  ? 133 TYR A CD2   1 ? 
ATOM   1040 C  CE1   . TYR A 1 133 ? 2.237   10.215  2.489   1.000 25.130  ? 133 TYR A CE1   1 ? 
ATOM   1041 C  CE2   . TYR A 1 133 ? 2.204   9.094   0.380   1.000 26.090  ? 133 TYR A CE2   1 ? 
ATOM   1042 C  CZ    . TYR A 1 133 ? 2.608   9.142   1.704   1.000 26.789  ? 133 TYR A CZ    1 ? 
ATOM   1043 O  OH    . TYR A 1 133 ? 3.352   8.112   2.224   1.000 27.731  ? 133 TYR A OH    1 ? 
ATOM   1044 N  N     . ALA A 1 134 ? -0.209  14.608  -2.285  1.000 26.846  ? 134 ALA A N     1 ? 
ATOM   1045 C  CA    . ALA A 1 134 ? -1.306  15.360  -2.939  1.000 34.747  ? 134 ALA A CA    1 ? 
ATOM   1046 C  C     . ALA A 1 134 ? -2.668  14.678  -2.683  1.000 36.495  ? 134 ALA A C     1 ? 
ATOM   1047 O  O     . ALA A 1 134 ? -2.781  13.441  -2.968  1.000 29.500  ? 134 ALA A O     1 ? 
ATOM   1048 C  CB    . ALA A 1 134 ? -1.037  15.445  -4.421  1.000 35.422  ? 134 ALA A CB    1 ? 
ATOM   1049 N  N     . ASP A 1 135 ? -3.670  15.478  -2.272  1.000 40.628  ? 135 ASP A N     1 ? 
ATOM   1050 C  CA    . ASP A 1 135 ? -5.092  15.073  -2.072  1.000 38.776  ? 135 ASP A CA    1 ? 
ATOM   1051 C  C     . ASP A 1 135 ? -5.547  14.187  -3.221  1.000 37.718  ? 135 ASP A C     1 ? 
ATOM   1052 O  O     . ASP A 1 135 ? -5.468  14.584  -4.379  1.000 40.271  ? 135 ASP A O     1 ? 
ATOM   1053 C  CB    . ASP A 1 135 ? -6.020  16.285  -1.985  1.000 41.687  ? 135 ASP A CB    1 ? 
ATOM   1054 C  CG    . ASP A 1 135 ? -7.340  15.991  -1.296  1.000 43.518  ? 135 ASP A CG    1 ? 
ATOM   1055 O  OD1   . ASP A 1 135 ? -7.990  14.962  -1.663  1.000 42.891  ? 135 ASP A OD1   1 ? 
ATOM   1056 O  OD2   . ASP A 1 135 ? -7.689  16.763  -0.371  1.000 39.902  ? 135 ASP A OD2   1 ? 
ATOM   1057 N  N     . PRO A 1 136 ? -6.042  12.960  -2.942  1.000 35.784  ? 136 PRO A N     1 ? 
ATOM   1058 C  CA    . PRO A 1 136 ? -6.587  12.100  -3.992  1.000 40.111  ? 136 PRO A CA    1 ? 
ATOM   1059 C  C     . PRO A 1 136 ? -7.823  12.671  -4.720  1.000 43.343  ? 136 PRO A C     1 ? 
ATOM   1060 O  O     . PRO A 1 136 ? -8.067  12.246  -5.880  1.000 42.623  ? 136 PRO A O     1 ? 
ATOM   1061 C  CB    . PRO A 1 136 ? -6.976  10.805  -3.253  1.000 37.264  ? 136 PRO A CB    1 ? 
ATOM   1062 C  CG    . PRO A 1 136 ? -6.162  10.841  -1.978  1.000 38.232  ? 136 PRO A CG    1 ? 
ATOM   1063 C  CD    . PRO A 1 136 ? -6.025  12.306  -1.629  1.000 35.950  ? 136 PRO A CD    1 ? 
ATOM   1064 N  N     . GLU A 1 137 ? -8.584  13.551  -4.042  1.000 44.584  ? 137 GLU A N     1 ? 
ATOM   1065 C  CA    . GLU A 1 137 ? -9.868  14.124  -4.540  1.000 49.054  ? 137 GLU A CA    1 ? 
ATOM   1066 C  C     . GLU A 1 137 ? -9.541  15.150  -5.624  1.000 48.536  ? 137 GLU A C     1 ? 
ATOM   1067 O  O     . GLU A 1 137 ? -10.102 15.033  -6.741  1.000 54.545  ? 137 GLU A O     1 ? 
ATOM   1068 C  CB    . GLU A 1 137 ? -10.681 14.756  -3.406  1.000 52.195  ? 137 GLU A CB    1 ? 
ATOM   1069 C  CG    . GLU A 1 137 ? -10.959 13.815  -2.244  1.000 58.736  ? 137 GLU A CG    1 ? 
ATOM   1070 C  CD    . GLU A 1 137 ? -11.864 12.633  -2.548  1.000 64.186  ? 137 GLU A CD    1 ? 
ATOM   1071 O  OE1   . GLU A 1 137 ? -11.330 11.524  -2.874  1.000 61.587  ? 137 GLU A OE1   1 ? 
ATOM   1072 O  OE2   . GLU A 1 137 ? -13.099 12.804  -2.411  1.000 72.814  ? 137 GLU A OE2   1 ? 
ATOM   1073 N  N     . LEU A 1 138 ? -8.597  16.050  -5.330  1.000 45.978  ? 138 LEU A N     1 ? 
ATOM   1074 C  CA    . LEU A 1 138 ? -8.123  17.126  -6.248  1.000 45.237  ? 138 LEU A CA    1 ? 
ATOM   1075 C  C     . LEU A 1 138 ? -7.166  16.565  -7.319  1.000 51.888  ? 138 LEU A C     1 ? 
ATOM   1076 O  O     . LEU A 1 138 ? -6.784  17.363  -8.216  1.000 56.433  ? 138 LEU A O     1 ? 
ATOM   1077 C  CB    . LEU A 1 138 ? -7.432  18.216  -5.420  1.000 40.859  ? 138 LEU A CB    1 ? 
ATOM   1078 C  CG    . LEU A 1 138 ? -8.298  18.852  -4.330  1.000 40.021  ? 138 LEU A CG    1 ? 
ATOM   1079 C  CD1   . LEU A 1 138 ? -7.493  19.761  -3.417  1.000 36.262  ? 138 LEU A CD1   1 ? 
ATOM   1080 C  CD2   . LEU A 1 138 ? -9.455  19.623  -4.949  1.000 40.646  ? 138 LEU A CD2   1 ? 
ATOM   1081 N  N     . SER A 1 139 ? -6.795  15.267  -7.249  1.000 47.904  ? 139 SER A N     1 ? 
ATOM   1082 C  CA    . SER A 1 139 ? -5.646  14.674  -8.000  1.000 43.936  ? 139 SER A CA    1 ? 
ATOM   1083 C  C     . SER A 1 139 ? -6.074  13.448  -8.812  1.000 42.925  ? 139 SER A C     1 ? 
ATOM   1084 O  O     . SER A 1 139 ? -5.185  12.765  -9.353  1.000 43.589  ? 139 SER A O     1 ? 
ATOM   1085 C  CB    . SER A 1 139 ? -4.504  14.329  -7.079  1.000 40.741  ? 139 SER A CB    1 ? 
ATOM   1086 O  OG    . SER A 1 139 ? -4.071  15.471  -6.356  1.000 36.000  ? 139 SER A OG    1 ? 
ATOM   1087 N  N     . GLY A 1 140 ? -7.376  13.179  -8.901  1.000 42.201  ? 140 GLY A N     1 ? 
ATOM   1088 C  CA    . GLY A 1 140 ? -7.937  12.221  -9.870  1.000 41.593  ? 140 GLY A CA    1 ? 
ATOM   1089 C  C     . GLY A 1 140 ? -8.162  10.845  -9.274  1.000 40.710  ? 140 GLY A C     1 ? 
ATOM   1090 O  O     . GLY A 1 140 ? -8.364  9.899   -10.070 1.000 41.979  ? 140 GLY A O     1 ? 
ATOM   1091 N  N     . GLY A 1 141 ? -8.127  10.732  -7.939  1.000 44.112  ? 141 GLY A N     1 ? 
ATOM   1092 C  CA    . GLY A 1 141 ? -8.514  9.519   -7.192  1.000 44.026  ? 141 GLY A CA    1 ? 
ATOM   1093 C  C     . GLY A 1 141 ? -7.322  8.695   -6.722  1.000 42.369  ? 141 GLY A C     1 ? 
ATOM   1094 O  O     . GLY A 1 141 ? -7.550  7.725   -5.976  1.000 46.344  ? 141 GLY A O     1 ? 
ATOM   1095 N  N     . THR A 1 142 ? -6.106  9.009   -7.182  1.000 39.248  ? 142 THR A N     1 ? 
ATOM   1096 C  CA    . THR A 1 142 ? -4.849  8.310   -6.784  1.000 36.553  ? 142 THR A CA    1 ? 
ATOM   1097 C  C     . THR A 1 142 ? -4.116  9.159   -5.732  1.000 36.526  ? 142 THR A C     1 ? 
ATOM   1098 O  O     . THR A 1 142 ? -3.927  10.388  -5.963  1.000 37.161  ? 142 THR A O     1 ? 
ATOM   1099 C  CB    . THR A 1 142 ? -3.925  7.993   -7.977  1.000 37.028  ? 142 THR A CB    1 ? 
ATOM   1100 O  OG1   . THR A 1 142 ? -3.126  9.146   -8.254  1.000 37.504  ? 142 THR A OG1   1 ? 
ATOM   1101 C  CG2   . THR A 1 142 ? -4.655  7.568   -9.234  1.000 36.829  ? 142 THR A CG2   1 ? 
ATOM   1102 N  N     . LEU A 1 143 ? -3.764  8.546   -4.601  1.000 34.085  ? 143 LEU A N     1 ? 
ATOM   1103 C  CA    . LEU A 1 143 ? -2.863  9.145   -3.584  1.000 34.535  ? 143 LEU A CA    1 ? 
ATOM   1104 C  C     . LEU A 1 143 ? -1.461  9.209   -4.186  1.000 37.094  ? 143 LEU A C     1 ? 
ATOM   1105 O  O     . LEU A 1 143 ? -1.006  8.177   -4.752  1.000 36.233  ? 143 LEU A O     1 ? 
ATOM   1106 C  CB    . LEU A 1 143 ? -2.863  8.316   -2.299  1.000 30.358  ? 143 LEU A CB    1 ? 
ATOM   1107 C  CG    . LEU A 1 143 ? -1.946  8.850   -1.197  1.000 30.353  ? 143 LEU A CG    1 ? 
ATOM   1108 C  CD1   . LEU A 1 143 ? -2.370  10.239  -0.736  1.000 30.550  ? 143 LEU A CD1   1 ? 
ATOM   1109 C  CD2   . LEU A 1 143 ? -1.903  7.900   -0.019  1.000 30.781  ? 143 LEU A CD2   1 ? 
ATOM   1110 N  N     . CYS A 1 144 ? -0.816  10.372  -4.113  1.000 34.586  ? 144 CYS A N     1 ? 
ATOM   1111 C  CA    . CYS A 1 144 ? 0.445   10.627  -4.850  1.000 32.175  ? 144 CYS A CA    1 ? 
ATOM   1112 C  C     . CYS A 1 144 ? 1.458   11.247  -3.890  1.000 30.165  ? 144 CYS A C     1 ? 
ATOM   1113 O  O     . CYS A 1 144 ? 1.126   12.221  -3.201  1.000 34.118  ? 144 CYS A O     1 ? 
ATOM   1114 C  CB    . CYS A 1 144 ? 0.179   11.441  -6.113  1.000 33.535  ? 144 CYS A CB    1 ? 
ATOM   1115 S  SG    . CYS A 1 144 ? -0.415  10.416  -7.491  1.000 34.600  ? 144 CYS A SG    1 ? 
ATOM   1116 N  N     . ILE A 1 145 ? 2.617   10.608  -3.760  1.000 30.093  ? 145 ILE A N     1 ? 
ATOM   1117 C  CA    . ILE A 1 145 ? 3.723   11.090  -2.881  1.000 29.685  ? 145 ILE A CA    1 ? 
ATOM   1118 C  C     . ILE A 1 145 ? 4.634   12.010  -3.706  1.000 27.343  ? 145 ILE A C     1 ? 
ATOM   1119 O  O     . ILE A 1 145 ? 4.805   11.762  -4.925  1.000 27.435  ? 145 ILE A O     1 ? 
ATOM   1120 C  CB    . ILE A 1 145 ? 4.498   9.902   -2.264  1.000 27.795  ? 145 ILE A CB    1 ? 
ATOM   1121 C  CG1   . ILE A 1 145 ? 5.337   10.338  -1.065  1.000 26.951  ? 145 ILE A CG1   1 ? 
ATOM   1122 C  CG2   . ILE A 1 145 ? 5.320   9.174   -3.318  1.000 25.817  ? 145 ILE A CG2   1 ? 
ATOM   1123 C  CD1   . ILE A 1 145 ? 6.062   9.190   -0.390  1.000 28.228  ? 145 ILE A CD1   1 ? 
ATOM   1124 N  N     . ALA A 1 146 ? 5.180   13.028  -3.055  1.000 27.553  ? 146 ALA A N     1 ? 
ATOM   1125 C  CA    . ALA A 1 146 ? 6.103   14.015  -3.651  1.000 28.882  ? 146 ALA A CA    1 ? 
ATOM   1126 C  C     . ALA A 1 146 ? 7.508   13.414  -3.690  1.000 28.256  ? 146 ALA A C     1 ? 
ATOM   1127 O  O     . ALA A 1 146 ? 8.095   13.231  -2.611  1.000 25.201  ? 146 ALA A O     1 ? 
ATOM   1128 C  CB    . ALA A 1 146 ? 6.059   15.290  -2.843  1.000 28.849  ? 146 ALA A CB    1 ? 
ATOM   1129 N  N     . LYS A 1 147 ? 8.013   13.084  -4.882  1.000 34.388  ? 147 LYS A N     1 ? 
ATOM   1130 C  CA    . LYS A 1 147 ? 9.400   12.569  -5.055  1.000 39.419  ? 147 LYS A CA    1 ? 
ATOM   1131 C  C     . LYS A 1 147 ? 10.280  13.668  -5.657  1.000 43.555  ? 147 LYS A C     1 ? 
ATOM   1132 O  O     . LYS A 1 147 ? 9.782   14.391  -6.531  1.000 38.749  ? 147 LYS A O     1 ? 
ATOM   1133 C  CB    . LYS A 1 147 ? 9.408   11.301  -5.912  1.000 41.613  ? 147 LYS A CB    1 ? 
ATOM   1134 C  CG    . LYS A 1 147 ? 9.137   10.021  -5.132  1.000 45.571  ? 147 LYS A CG    1 ? 
ATOM   1135 C  CD    . LYS A 1 147 ? 9.989   8.827   -5.560  1.000 48.166  ? 147 LYS A CD    1 ? 
ATOM   1136 C  CE    . LYS A 1 147 ? 10.256  7.859   -4.421  1.000 47.421  ? 147 LYS A CE    1 ? 
ATOM   1137 N  NZ    . LYS A 1 147 ? 10.632  6.508   -4.906  1.000 47.950  ? 147 LYS A NZ    1 ? 
ATOM   1138 N  N     . GLY A 1 148 ? 11.528  13.780  -5.170  1.000 50.166  ? 148 GLY A N     1 ? 
ATOM   1139 C  CA    . GLY A 1 148 ? 12.586  14.678  -5.686  1.000 51.728  ? 148 GLY A CA    1 ? 
ATOM   1140 C  C     . GLY A 1 148 ? 13.249  15.461  -4.565  1.000 53.142  ? 148 GLY A C     1 ? 
ATOM   1141 O  O     . GLY A 1 148 ? 12.552  15.800  -3.599  1.000 57.872  ? 148 GLY A O     1 ? 
ATOM   1142 N  N     . LYS A 1 149 ? 14.552  15.736  -4.684  1.000 57.302  ? 149 LYS A N     1 ? 
ATOM   1143 C  CA    . LYS A 1 149 ? 15.335  16.582  -3.735  1.000 56.451  ? 149 LYS A CA    1 ? 
ATOM   1144 C  C     . LYS A 1 149 ? 15.602  17.951  -4.371  1.000 51.906  ? 149 LYS A C     1 ? 
ATOM   1145 O  O     . LYS A 1 149 ? 15.520  18.047  -5.609  1.000 40.453  ? 149 LYS A O     1 ? 
ATOM   1146 C  CB    . LYS A 1 149 ? 16.679  15.928  -3.391  1.000 65.186  ? 149 LYS A CB    1 ? 
ATOM   1147 C  CG    . LYS A 1 149 ? 16.668  14.966  -2.210  1.000 66.495  ? 149 LYS A CG    1 ? 
ATOM   1148 C  CD    . LYS A 1 149 ? 18.059  14.553  -1.737  1.000 62.733  ? 149 LYS A CD    1 ? 
ATOM   1149 C  CE    . LYS A 1 149 ? 18.612  13.346  -2.468  1.000 61.774  ? 149 LYS A CE    1 ? 
ATOM   1150 N  NZ    . LYS A 1 149 ? 19.395  13.724  -3.668  1.000 58.278  ? 149 LYS A NZ    1 ? 
ATOM   1151 N  N     . GLU A 1 150 ? 15.963  18.950  -3.554  1.000 47.779  ? 150 GLU A N     1 ? 
ATOM   1152 C  CA    . GLU A 1 150 ? 16.268  20.336  -4.011  1.000 50.459  ? 150 GLU A CA    1 ? 
ATOM   1153 C  C     . GLU A 1 150 ? 17.322  20.302  -5.119  1.000 51.612  ? 150 GLU A C     1 ? 
ATOM   1154 O  O     . GLU A 1 150 ? 17.218  21.131  -6.049  1.000 49.049  ? 150 GLU A O     1 ? 
ATOM   1155 C  CB    . GLU A 1 150 ? 16.753  21.206  -2.854  1.000 47.075  ? 150 GLU A CB    1 ? 
ATOM   1156 C  CG    . GLU A 1 150 ? 15.616  21.842  -2.101  1.000 45.410  ? 150 GLU A CG    1 ? 
ATOM   1157 C  CD    . GLU A 1 150 ? 16.016  22.608  -0.859  1.000 45.753  ? 150 GLU A CD    1 ? 
ATOM   1158 O  OE1   . GLU A 1 150 ? 15.326  23.581  -0.538  1.000 43.452  ? 150 GLU A OE1   1 ? 
ATOM   1159 O  OE2   . GLU A 1 150 ? 16.995  22.209  -0.200  1.000 50.166  ? 150 GLU A OE2   1 ? 
ATOM   1160 N  N     . ASN A 1 151 ? 18.263  19.352  -5.028  1.000 62.799  ? 151 ASN A N     1 ? 
ATOM   1161 C  CA    . ASN A 1 151 ? 19.482  19.245  -5.879  1.000 70.558  ? 151 ASN A CA    1 ? 
ATOM   1162 C  C     . ASN A 1 151 ? 19.198  18.407  -7.137  1.000 70.491  ? 151 ASN A C     1 ? 
ATOM   1163 O  O     . ASN A 1 151 ? 20.122  18.270  -7.959  1.000 68.219  ? 151 ASN A O     1 ? 
ATOM   1164 C  CB    . ASN A 1 151 ? 20.655  18.632  -5.101  1.000 73.635  ? 151 ASN A CB    1 ? 
ATOM   1165 C  CG    . ASN A 1 151 ? 20.456  17.161  -4.778  1.000 75.667  ? 151 ASN A CG    1 ? 
ATOM   1166 O  OD1   . ASN A 1 151 ? 20.278  16.336  -5.676  1.000 74.025  ? 151 ASN A OD1   1 ? 
ATOM   1167 N  ND2   . ASN A 1 151 ? 20.492  16.819  -3.499  1.000 72.028  ? 151 ASN A ND2   1 ? 
ATOM   1168 N  N     . SER A 1 152 ? 17.990  17.848  -7.272  1.000 69.827  ? 152 SER A N     1 ? 
ATOM   1169 C  CA    . SER A 1 152 ? 17.649  16.826  -8.299  1.000 75.096  ? 152 SER A CA    1 ? 
ATOM   1170 C  C     . SER A 1 152 ? 17.100  17.505  -9.556  1.000 78.634  ? 152 SER A C     1 ? 
ATOM   1171 O  O     . SER A 1 152 ? 16.729  18.699  -9.474  1.000 83.706  ? 152 SER A O     1 ? 
ATOM   1172 C  CB    . SER A 1 152 ? 16.677  15.808  -7.756  1.000 76.079  ? 152 SER A CB    1 ? 
ATOM   1173 O  OG    . SER A 1 152 ? 15.517  16.437  -7.226  1.000 67.965  ? 152 SER A OG    1 ? 
ATOM   1174 N  N     . GLY A 1 153 ? 17.070  16.774  -10.675 1.000 77.915  ? 153 GLY A N     1 ? 
ATOM   1175 C  CA    . GLY A 1 153 ? 16.559  17.267  -11.967 1.000 77.556  ? 153 GLY A CA    1 ? 
ATOM   1176 C  C     . GLY A 1 153 ? 15.051  17.402  -11.937 1.000 76.224  ? 153 GLY A C     1 ? 
ATOM   1177 O  O     . GLY A 1 153 ? 14.507  17.554  -10.834 1.000 81.051  ? 153 GLY A O     1 ? 
ATOM   1178 N  N     . ASP A 1 154 ? 14.397  17.329  -13.101 1.000 73.705  ? 154 ASP A N     1 ? 
ATOM   1179 C  CA    . ASP A 1 154 ? 12.912  17.336  -13.222 1.000 68.967  ? 154 ASP A CA    1 ? 
ATOM   1180 C  C     . ASP A 1 154 ? 12.413  15.934  -13.605 1.000 65.482  ? 154 ASP A C     1 ? 
ATOM   1181 O  O     . ASP A 1 154 ? 11.322  15.565  -13.146 1.000 60.387  ? 154 ASP A O     1 ? 
ATOM   1182 C  CB    . ASP A 1 154 ? 12.432  18.431  -14.178 1.000 66.122  ? 154 ASP A CB    1 ? 
ATOM   1183 C  CG    . ASP A 1 154 ? 11.866  19.636  -13.444 1.000 66.193  ? 154 ASP A CG    1 ? 
ATOM   1184 O  OD1   . ASP A 1 154 ? 10.694  19.972  -13.693 1.000 60.335  ? 154 ASP A OD1   1 ? 
ATOM   1185 O  OD2   . ASP A 1 154 ? 12.595  20.209  -12.604 1.000 69.093  ? 154 ASP A OD2   1 ? 
ATOM   1186 N  N     . GLU A 1 155 ? 13.195  15.171  -14.373 1.000 63.732  ? 155 GLU A N     1 ? 
ATOM   1187 C  CA    . GLU A 1 155 ? 12.928  13.733  -14.656 1.000 65.789  ? 155 GLU A CA    1 ? 
ATOM   1188 C  C     . GLU A 1 155 ? 12.577  13.000  -13.352 1.000 74.069  ? 155 GLU A C     1 ? 
ATOM   1189 O  O     . GLU A 1 155 ? 11.717  12.112  -13.403 1.000 86.768  ? 155 GLU A O     1 ? 
ATOM   1190 C  CB    . GLU A 1 155 ? 14.125  13.017  -15.293 1.000 67.582  ? 155 GLU A CB    1 ? 
ATOM   1191 C  CG    . GLU A 1 155 ? 15.188  13.935  -15.879 1.000 70.406  ? 155 GLU A CG    1 ? 
ATOM   1192 C  CD    . GLU A 1 155 ? 16.142  14.555  -14.869 1.000 70.291  ? 155 GLU A CD    1 ? 
ATOM   1193 O  OE1   . GLU A 1 155 ? 15.947  14.344  -13.656 1.000 70.069  ? 155 GLU A OE1   1 ? 
ATOM   1194 O  OE2   . GLU A 1 155 ? 17.081  15.251  -15.303 1.000 76.181  ? 155 GLU A OE2   1 ? 
ATOM   1195 N  N     . HIS A 1 156 ? 13.256  13.323  -12.244 1.000 75.739  ? 156 HIS A N     1 ? 
ATOM   1196 C  CA    . HIS A 1 156 ? 13.129  12.624  -10.934 1.000 74.628  ? 156 HIS A CA    1 ? 
ATOM   1197 C  C     . HIS A 1 156 ? 12.393  13.517  -9.923  1.000 70.940  ? 156 HIS A C     1 ? 
ATOM   1198 O  O     . HIS A 1 156 ? 12.374  13.160  -8.723  1.000 67.482  ? 156 HIS A O     1 ? 
ATOM   1199 C  CB    . HIS A 1 156 ? 14.514  12.146  -10.456 1.000 82.955  ? 156 HIS A CB    1 ? 
ATOM   1200 C  CG    . HIS A 1 156 ? 14.971  10.881  -11.116 1.000 82.298  ? 156 HIS A CG    1 ? 
ATOM   1201 N  ND1   . HIS A 1 156 ? 16.195  10.773  -11.758 1.000 78.483  ? 156 HIS A ND1   1 ? 
ATOM   1202 C  CD2   . HIS A 1 156 ? 14.366  9.678   -11.254 1.000 78.316  ? 156 HIS A CD2   1 ? 
ATOM   1203 C  CE1   . HIS A 1 156 ? 16.324  9.557   -12.251 1.000 75.828  ? 156 HIS A CE1   1 ? 
ATOM   1204 N  NE2   . HIS A 1 156 ? 15.216  8.867   -11.957 1.000 74.441  ? 156 HIS A NE2   1 ? 
ATOM   1205 N  N     . ARG A 1 157 ? 11.813  14.634  -10.386 1.000 71.470  ? 157 ARG A N     1 ? 
ATOM   1206 C  CA    . ARG A 1 157 ? 10.667  15.323  -9.724  1.000 69.297  ? 157 ARG A CA    1 ? 
ATOM   1207 C  C     . ARG A 1 157 ? 9.369   14.678  -10.227 1.000 64.689  ? 157 ARG A C     1 ? 
ATOM   1208 O  O     . ARG A 1 157 ? 9.059   14.837  -11.422 1.000 62.517  ? 157 ARG A O     1 ? 
ATOM   1209 C  CB    . ARG A 1 157 ? 10.661  16.823  -10.025 1.000 70.515  ? 157 ARG A CB    1 ? 
ATOM   1210 C  CG    . ARG A 1 157 ? 11.689  17.629  -9.247  1.000 69.902  ? 157 ARG A CG    1 ? 
ATOM   1211 C  CD    . ARG A 1 157 ? 11.899  18.977  -9.910  1.000 71.626  ? 157 ARG A CD    1 ? 
ATOM   1212 N  NE    . ARG A 1 157 ? 11.928  20.063  -8.944  1.000 76.041  ? 157 ARG A NE    1 ? 
ATOM   1213 C  CZ    . ARG A 1 157 ? 11.523  21.311  -9.180  1.000 82.973  ? 157 ARG A CZ    1 ? 
ATOM   1214 N  NH1   . ARG A 1 157 ? 11.040  21.650  -10.367 1.000 88.442  ? 157 ARG A NH1   1 ? 
ATOM   1215 N  NH2   . ARG A 1 157 ? 11.587  22.218  -8.217  1.000 78.577  ? 157 ARG A NH2   1 ? 
ATOM   1216 N  N     . LEU A 1 158 ? 8.680   13.929  -9.361  1.000 61.287  ? 158 LEU A N     1 ? 
ATOM   1217 C  CA    . LEU A 1 158 ? 7.494   13.102  -9.710  1.000 54.764  ? 158 LEU A CA    1 ? 
ATOM   1218 C  C     . LEU A 1 158 ? 6.350   13.424  -8.750  1.000 53.029  ? 158 LEU A C     1 ? 
ATOM   1219 O  O     . LEU A 1 158 ? 6.614   13.988  -7.666  1.000 60.735  ? 158 LEU A O     1 ? 
ATOM   1220 C  CB    . LEU A 1 158 ? 7.869   11.621  -9.599  1.000 56.527  ? 158 LEU A CB    1 ? 
ATOM   1221 C  CG    . LEU A 1 158 ? 8.364   10.941  -10.874 1.000 60.615  ? 158 LEU A CG    1 ? 
ATOM   1222 C  CD1   . LEU A 1 158 ? 7.358   11.091  -12.012 1.000 60.784  ? 158 LEU A CD1   1 ? 
ATOM   1223 C  CD2   . LEU A 1 158 ? 9.727   11.470  -11.288 1.000 63.897  ? 158 LEU A CD2   1 ? 
ATOM   1224 N  N     . TRP A 1 159 ? 5.131   13.052  -9.128  1.000 45.012  ? 159 TRP A N     1 ? 
ATOM   1225 C  CA    . TRP A 1 159 ? 4.034   12.731  -8.184  1.000 38.220  ? 159 TRP A CA    1 ? 
ATOM   1226 C  C     . TRP A 1 159 ? 3.706   11.260  -8.374  1.000 37.470  ? 159 TRP A C     1 ? 
ATOM   1227 O  O     . TRP A 1 159 ? 2.951   10.963  -9.311  1.000 44.967  ? 159 TRP A O     1 ? 
ATOM   1228 C  CB    . TRP A 1 159 ? 2.800   13.616  -8.418  1.000 35.832  ? 159 TRP A CB    1 ? 
ATOM   1229 C  CG    . TRP A 1 159 ? 2.898   15.000  -7.854  1.000 32.236  ? 159 TRP A CG    1 ? 
ATOM   1230 C  CD1   . TRP A 1 159 ? 3.066   16.150  -8.571  1.000 30.224  ? 159 TRP A CD1   1 ? 
ATOM   1231 C  CD2   . TRP A 1 159 ? 2.816   15.401  -6.471  1.000 30.395  ? 159 TRP A CD2   1 ? 
ATOM   1232 N  NE1   . TRP A 1 159 ? 3.100   17.232  -7.737  1.000 28.445  ? 159 TRP A NE1   1 ? 
ATOM   1233 C  CE2   . TRP A 1 159 ? 2.937   16.809  -6.445  1.000 29.280  ? 159 TRP A CE2   1 ? 
ATOM   1234 C  CE3   . TRP A 1 159 ? 2.652   14.727  -5.254  1.000 30.424  ? 159 TRP A CE3   1 ? 
ATOM   1235 C  CZ2   . TRP A 1 159 ? 2.906   17.536  -5.257  1.000 28.033  ? 159 TRP A CZ2   1 ? 
ATOM   1236 C  CZ3   . TRP A 1 159 ? 2.631   15.444  -4.077  1.000 26.702  ? 159 TRP A CZ3   1 ? 
ATOM   1237 C  CH2   . TRP A 1 159 ? 2.758   16.831  -4.082  1.000 30.300  ? 159 TRP A CH2   1 ? 
ATOM   1238 N  N     . GLN A 1 160 ? 4.297   10.374  -7.568  1.000 35.845  ? 160 GLN A N     1 ? 
ATOM   1239 C  CA    . GLN A 1 160 ? 4.189   8.900   -7.769  1.000 33.808  ? 160 GLN A CA    1 ? 
ATOM   1240 C  C     . GLN A 1 160 ? 2.982   8.331   -7.006  1.000 29.318  ? 160 GLN A C     1 ? 
ATOM   1241 O  O     . GLN A 1 160 ? 2.813   8.644   -5.818  1.000 27.511  ? 160 GLN A O     1 ? 
ATOM   1242 C  CB    . GLN A 1 160 ? 5.476   8.207   -7.335  1.000 32.830  ? 160 GLN A CB    1 ? 
ATOM   1243 C  CG    . GLN A 1 160 ? 5.657   6.832   -7.964  1.000 30.115  ? 160 GLN A CG    1 ? 
ATOM   1244 C  CD    . GLN A 1 160 ? 7.015   6.236   -7.647  1.000 32.845  ? 160 GLN A CD    1 ? 
ATOM   1245 O  OE1   . GLN A 1 160 ? 7.557   6.413   -6.554  1.000 29.743  ? 160 GLN A OE1   1 ? 
ATOM   1246 N  NE2   . GLN A 1 160 ? 7.570   5.501   -8.602  1.000 32.693  ? 160 GLN A NE2   1 ? 
ATOM   1247 N  N     . ILE A 1 161 ? 2.189   7.513   -7.685  1.000 28.202  ? 161 ILE A N     1 ? 
ATOM   1248 C  CA    . ILE A 1 161 ? 1.099   6.678   -7.102  1.000 31.128  ? 161 ILE A CA    1 ? 
ATOM   1249 C  C     . ILE A 1 161 ? 1.653   5.846   -5.914  1.000 33.006  ? 161 ILE A C     1 ? 
ATOM   1250 O  O     . ILE A 1 161 ? 2.583   5.047   -6.127  1.000 31.118  ? 161 ILE A O     1 ? 
ATOM   1251 C  CB    . ILE A 1 161 ? 0.475   5.817   -8.219  1.000 33.256  ? 161 ILE A CB    1 ? 
ATOM   1252 C  CG1   . ILE A 1 161 ? -0.734  5.018   -7.736  1.000 36.390  ? 161 ILE A CG1   1 ? 
ATOM   1253 C  CG2   . ILE A 1 161 ? 1.507   4.910   -8.882  1.000 37.261  ? 161 ILE A CG2   1 ? 
ATOM   1254 C  CD1   . ILE A 1 161 ? -1.622  4.520   -8.874  1.000 40.816  ? 161 ILE A CD1   1 ? 
ATOM   1255 N  N     . SER A 1 162 ? 1.128   6.082   -4.700  1.000 31.982  ? 162 SER A N     1 ? 
ATOM   1256 C  CA    . SER A 1 162 ? 1.545   5.460   -3.411  1.000 33.292  ? 162 SER A CA    1 ? 
ATOM   1257 C  C     . SER A 1 162 ? 0.384   4.685   -2.747  1.000 31.187  ? 162 SER A C     1 ? 
ATOM   1258 O  O     . SER A 1 162 ? -0.794  5.031   -2.999  1.000 33.986  ? 162 SER A O     1 ? 
ATOM   1259 C  CB    . SER A 1 162 ? 2.059   6.492   -2.471  1.000 31.958  ? 162 SER A CB    1 ? 
ATOM   1260 O  OG    . SER A 1 162 ? 3.350   6.886   -2.845  1.000 39.216  ? 162 SER A OG    1 ? 
ATOM   1261 N  N     . ASP A 1 163 ? 0.722   3.728   -1.871  1.000 26.167  ? 163 ASP A N     1 ? 
ATOM   1262 C  CA    . ASP A 1 163 ? -0.229  2.942   -1.039  1.000 22.682  ? 163 ASP A CA    1 ? 
ATOM   1263 C  C     . ASP A 1 163 ? 0.465   2.554   0.261   1.000 22.540  ? 163 ASP A C     1 ? 
ATOM   1264 O  O     . ASP A 1 163 ? 0.608   1.379   0.595   1.000 21.689  ? 163 ASP A O     1 ? 
ATOM   1265 C  CB    . ASP A 1 163 ? -0.744  1.725   -1.791  1.000 22.135  ? 163 ASP A CB    1 ? 
ATOM   1266 C  CG    . ASP A 1 163 ? -1.975  1.080   -1.156  1.000 21.151  ? 163 ASP A CG    1 ? 
ATOM   1267 O  OD1   . ASP A 1 163 ? -2.555  1.691   -0.229  1.000 21.141  ? 163 ASP A OD1   1 ? 
ATOM   1268 O  OD2   . ASP A 1 163 ? -2.336  -0.028  -1.594  1.000 19.720  ? 163 ASP A OD2   1 ? 
ATOM   1269 N  N     . PRO A 1 164 ? 0.889   3.554   1.054   1.000 23.089  ? 164 PRO A N     1 ? 
ATOM   1270 C  CA    . PRO A 1 164 ? 1.418   3.305   2.392   1.000 22.414  ? 164 PRO A CA    1 ? 
ATOM   1271 C  C     . PRO A 1 164 ? 0.487   2.467   3.295   1.000 23.518  ? 164 PRO A C     1 ? 
ATOM   1272 O  O     . PRO A 1 164 ? 0.977   1.612   3.995   1.000 24.115  ? 164 PRO A O     1 ? 
ATOM   1273 C  CB    . PRO A 1 164 ? 1.617   4.724   2.955   1.000 21.781  ? 164 PRO A CB    1 ? 
ATOM   1274 C  CG    . PRO A 1 164 ? 0.737   5.608   2.100   1.000 22.691  ? 164 PRO A CG    1 ? 
ATOM   1275 C  CD    . PRO A 1 164 ? 0.796   4.985   0.731   1.000 22.736  ? 164 PRO A CD    1 ? 
ATOM   1276 N  N     . GLN A 1 165 ? -0.823  2.715   3.268   1.000 22.761  ? 165 GLN A N     1 ? 
ATOM   1277 C  CA    . GLN A 1 165 ? -1.792  2.016   4.158   1.000 23.167  ? 165 GLN A CA    1 ? 
ATOM   1278 C  C     . GLN A 1 165 ? -1.983  0.585   3.634   1.000 20.672  ? 165 GLN A C     1 ? 
ATOM   1279 O  O     . GLN A 1 165 ? -1.905  -0.332  4.442   1.000 20.842  ? 165 GLN A O     1 ? 
ATOM   1280 C  CB    . GLN A 1 165 ? -3.086  2.825   4.307   1.000 27.036  ? 165 GLN A CB    1 ? 
ATOM   1281 C  CG    . GLN A 1 165 ? -2.821  4.265   4.755   1.000 34.199  ? 165 GLN A CG    1 ? 
ATOM   1282 C  CD    . GLN A 1 165 ? -3.911  4.915   5.589   1.000 38.832  ? 165 GLN A CD    1 ? 
ATOM   1283 O  OE1   . GLN A 1 165 ? -3.875  4.908   6.822   1.000 37.696  ? 165 GLN A OE1   1 ? 
ATOM   1284 N  NE2   . GLN A 1 165 ? -4.832  5.590   4.917   1.000 42.958  ? 165 GLN A NE2   1 ? 
ATOM   1285 N  N     . GLY A 1 166 ? -2.093  0.417   2.314   1.000 18.857  ? 166 GLY A N     1 ? 
ATOM   1286 C  CA    . GLY A 1 166 ? -2.009  -0.871  1.613   1.000 17.030  ? 166 GLY A CA    1 ? 
ATOM   1287 C  C     . GLY A 1 166 ? -0.797  -1.708  2.050   1.000 17.062  ? 166 GLY A C     1 ? 
ATOM   1288 O  O     . GLY A 1 166 ? -0.968  -2.914  2.286   1.000 16.537  ? 166 GLY A O     1 ? 
ATOM   1289 N  N     . PHE A 1 167 ? 0.394   -1.130  2.123   1.000 16.446  ? 167 PHE A N     1 ? 
ATOM   1290 C  CA    . PHE A 1 167 ? 1.628   -1.869  2.486   1.000 16.276  ? 167 PHE A CA    1 ? 
ATOM   1291 C  C     . PHE A 1 167 ? 1.549   -2.276  3.968   1.000 16.392  ? 167 PHE A C     1 ? 
ATOM   1292 O  O     . PHE A 1 167 ? 1.786   -3.461  4.289   1.000 16.167  ? 167 PHE A O     1 ? 
ATOM   1293 C  CB    . PHE A 1 167 ? 2.881   -1.043  2.172   1.000 17.195  ? 167 PHE A CB    1 ? 
ATOM   1294 C  CG    . PHE A 1 167 ? 4.164   -1.715  2.600   1.000 17.846  ? 167 PHE A CG    1 ? 
ATOM   1295 C  CD1   . PHE A 1 167 ? 4.690   -2.779  1.880   1.000 18.865  ? 167 PHE A CD1   1 ? 
ATOM   1296 C  CD2   . PHE A 1 167 ? 4.819   -1.311  3.743   1.000 18.287  ? 167 PHE A CD2   1 ? 
ATOM   1297 C  CE1   . PHE A 1 167 ? 5.853   -3.410  2.299   1.000 20.489  ? 167 PHE A CE1   1 ? 
ATOM   1298 C  CE2   . PHE A 1 167 ? 5.979   -1.938  4.153   1.000 18.620  ? 167 PHE A CE2   1 ? 
ATOM   1299 C  CZ    . PHE A 1 167 ? 6.487   -2.994  3.449   1.000 18.329  ? 167 PHE A CZ    1 ? 
ATOM   1300 N  N     . GLN A 1 168 ? 1.151   -1.359  4.836   1.000 17.246  ? 168 GLN A N     1 ? 
ATOM   1301 C  CA    . GLN A 1 168 ? 1.057   -1.626  6.291   1.000 21.786  ? 168 GLN A CA    1 ? 
ATOM   1302 C  C     . GLN A 1 168 ? 0.109   -2.812  6.481   1.000 23.394  ? 168 GLN A C     1 ? 
ATOM   1303 O  O     . GLN A 1 168 ? 0.373   -3.702  7.299   1.000 21.459  ? 168 GLN A O     1 ? 
ATOM   1304 C  CB    . GLN A 1 168 ? 0.558   -0.382  7.018   1.000 26.350  ? 168 GLN A CB    1 ? 
ATOM   1305 C  CG    . GLN A 1 168 ? 1.487   0.827   6.903   1.000 30.848  ? 168 GLN A CG    1 ? 
ATOM   1306 C  CD    . GLN A 1 168 ? 0.869   2.061   7.513   1.000 31.637  ? 168 GLN A CD    1 ? 
ATOM   1307 O  OE1   . GLN A 1 168 ? -0.067  1.983   8.307   1.000 32.129  ? 168 GLN A OE1   1 ? 
ATOM   1308 N  NE2   . GLN A 1 168 ? 1.417   3.213   7.175   1.000 38.323  ? 168 GLN A NE2   1 ? 
ATOM   1309 N  N     . ASP A 1 169 ? -0.895  -2.838  5.625   1.000 27.633  ? 169 ASP A N     1 ? 
ATOM   1310 C  CA    . ASP A 1 169 ? -1.990  -3.821  5.560   1.000 31.134  ? 169 ASP A CA    1 ? 
ATOM   1311 C  C     . ASP A 1 169 ? -1.499  -5.197  5.156   1.000 29.103  ? 169 ASP A C     1 ? 
ATOM   1312 O  O     . ASP A 1 169 ? -1.988  -6.154  5.720   1.000 36.158  ? 169 ASP A O     1 ? 
ATOM   1313 C  CB    . ASP A 1 169 ? -2.970  -3.394  4.483   1.000 39.010  ? 169 ASP A CB    1 ? 
ATOM   1314 C  CG    . ASP A 1 169 ? -4.364  -3.449  4.995   1.000 43.928  ? 169 ASP A CG    1 ? 
ATOM   1315 O  OD1   . ASP A 1 169 ? -4.872  -2.377  5.406   1.000 53.296  ? 169 ASP A OD1   1 ? 
ATOM   1316 O  OD2   . ASP A 1 169 ? -4.878  -4.564  5.074   1.000 57.824  ? 169 ASP A OD2   1 ? 
ATOM   1317 N  N     . ARG A 1 170 ? -0.705  -5.293  4.089   1.000 27.593  ? 170 ARG A N     1 ? 
ATOM   1318 C  CA    . ARG A 1 170 ? -0.123  -6.586  3.650   1.000 23.915  ? 170 ARG A CA    1 ? 
ATOM   1319 C  C     . ARG A 1 170 ? 0.698   -7.175  4.807   1.000 19.783  ? 170 ARG A C     1 ? 
ATOM   1320 O  O     . ARG A 1 170 ? 0.611   -8.372  5.029   1.000 22.453  ? 170 ARG A O     1 ? 
ATOM   1321 C  CB    . ARG A 1 170 ? 0.729   -6.419  2.392   1.000 25.738  ? 170 ARG A CB    1 ? 
ATOM   1322 C  CG    . ARG A 1 170 ? 0.010   -5.800  1.200   1.000 29.735  ? 170 ARG A CG    1 ? 
ATOM   1323 C  CD    . ARG A 1 170 ? -1.249  -6.520  0.757   1.000 32.742  ? 170 ARG A CD    1 ? 
ATOM   1324 N  NE    . ARG A 1 170 ? -2.143  -5.582  0.088   1.000 35.281  ? 170 ARG A NE    1 ? 
ATOM   1325 C  CZ    . ARG A 1 170 ? -2.374  -5.551  -1.211  1.000 37.345  ? 170 ARG A CZ    1 ? 
ATOM   1326 N  NH1   . ARG A 1 170 ? -1.794  -6.429  -2.013  1.000 47.073  ? 170 ARG A NH1   1 ? 
ATOM   1327 N  NH2   . ARG A 1 170 ? -3.208  -4.657  -1.710  1.000 37.865  ? 170 ARG A NH2   1 ? 
ATOM   1328 N  N     . ILE A 1 171 ? 1.482   -6.364  5.504   1.000 18.176  ? 171 ILE A N     1 ? 
ATOM   1329 C  CA    . ILE A 1 171 ? 2.389   -6.840  6.582   1.000 18.963  ? 171 ILE A CA    1 ? 
ATOM   1330 C  C     . ILE A 1 171 ? 1.518   -7.382  7.734   1.000 19.928  ? 171 ILE A C     1 ? 
ATOM   1331 O  O     . ILE A 1 171 ? 1.717   -8.562  8.111   1.000 18.076  ? 171 ILE A O     1 ? 
ATOM   1332 C  CB    . ILE A 1 171 ? 3.393   -5.748  7.002   1.000 18.955  ? 171 ILE A CB    1 ? 
ATOM   1333 C  CG1   . ILE A 1 171 ? 4.353   -5.378  5.857   1.000 18.828  ? 171 ILE A CG1   1 ? 
ATOM   1334 C  CG2   . ILE A 1 171 ? 4.161   -6.163  8.258   1.000 20.177  ? 171 ILE A CG2   1 ? 
ATOM   1335 C  CD1   . ILE A 1 171 ? 5.039   -6.572  5.155   1.000 17.460  ? 171 ILE A CD1   1 ? 
ATOM   1336 N  N     . ALA A 1 172 ? 0.496   -6.630  8.164   1.000 20.115  ? 172 ALA A N     1 ? 
ATOM   1337 C  CA    . ALA A 1 172 ? -0.468  -7.048  9.220   1.000 19.820  ? 172 ALA A CA    1 ? 
ATOM   1338 C  C     . ALA A 1 172 ? -1.244  -8.309  8.804   1.000 20.722  ? 172 ALA A C     1 ? 
ATOM   1339 O  O     . ALA A 1 172 ? -1.577  -9.101  9.691   1.000 22.098  ? 172 ALA A O     1 ? 
ATOM   1340 C  CB    . ALA A 1 172 ? -1.411  -5.922  9.536   1.000 20.037  ? 172 ALA A CB    1 ? 
ATOM   1341 N  N     . SER A 1 173 ? -1.505  -8.495  7.514   1.000 20.675  ? 173 SER A N     1 ? 
ATOM   1342 C  CA    . SER A 1 173 ? -2.414  -9.550  6.986   1.000 23.739  ? 173 SER A CA    1 ? 
ATOM   1343 C  C     . SER A 1 173 ? -1.670  -10.849 6.728   1.000 22.443  ? 173 SER A C     1 ? 
ATOM   1344 O  O     . SER A 1 173 ? -2.361  -11.833 6.477   1.000 22.684  ? 173 SER A O     1 ? 
ATOM   1345 C  CB    . SER A 1 173 ? -3.088  -9.144  5.684   1.000 24.720  ? 173 SER A CB    1 ? 
ATOM   1346 O  OG    . SER A 1 173 ? -4.229  -8.365  5.927   1.000 28.963  ? 173 SER A OG    1 ? 
ATOM   1347 N  N     . LYS A 1 174 ? -0.338  -10.831 6.658   1.000 24.639  ? 174 LYS A N     1 ? 
ATOM   1348 C  CA    . LYS A 1 174 ? 0.437   -11.964 6.080   1.000 25.954  ? 174 LYS A CA    1 ? 
ATOM   1349 C  C     . LYS A 1 174 ? 0.010   -13.258 6.770   1.000 31.064  ? 174 LYS A C     1 ? 
ATOM   1350 O  O     . LYS A 1 174 ? -0.451  -14.195 6.074   1.000 35.735  ? 174 LYS A O     1 ? 
ATOM   1351 C  CB    . LYS A 1 174 ? 1.947   -11.793 6.220   1.000 23.658  ? 174 LYS A CB    1 ? 
ATOM   1352 C  CG    . LYS A 1 174 ? 2.738   -13.008 5.756   1.000 21.847  ? 174 LYS A CG    1 ? 
ATOM   1353 C  CD    . LYS A 1 174 ? 4.131   -12.684 5.319   1.000 21.993  ? 174 LYS A CD    1 ? 
ATOM   1354 C  CE    . LYS A 1 174 ? 4.906   -13.935 4.967   1.000 22.791  ? 174 LYS A CE    1 ? 
ATOM   1355 N  NZ    . LYS A 1 174 ? 4.581   -14.394 3.599   1.000 22.695  ? 174 LYS A NZ    1 ? 
ATOM   1356 N  N     . LEU A 1 175 ? 0.191   -13.316 8.080   1.000 32.417  ? 175 LEU A N     1 ? 
ATOM   1357 C  CA    . LEU A 1 175 ? -0.217  -14.477 8.898   1.000 36.938  ? 175 LEU A CA    1 ? 
ATOM   1358 C  C     . LEU A 1 175 ? -1.035  -13.936 10.065  1.000 35.442  ? 175 LEU A C     1 ? 
ATOM   1359 O  O     . LEU A 1 175 ? -1.370  -12.719 10.032  1.000 39.237  ? 175 LEU A O     1 ? 
ATOM   1360 C  CB    . LEU A 1 175 ? 1.046   -15.224 9.351   1.000 35.252  ? 175 LEU A CB    1 ? 
ATOM   1361 C  CG    . LEU A 1 175 ? 1.868   -15.823 8.220   1.000 36.971  ? 175 LEU A CG    1 ? 
ATOM   1362 C  CD1   . LEU A 1 175 ? 3.351   -15.681 8.495   1.000 38.059  ? 175 LEU A CD1   1 ? 
ATOM   1363 C  CD2   . LEU A 1 175 ? 1.494   -17.274 7.976   1.000 36.740  ? 175 LEU A CD2   1 ? 
ATOM   1364 N  N     . SER A 1 176 ? -1.271  -14.778 11.071  1.000 36.316  ? 176 SER A N     1 ? 
ATOM   1365 C  CA    . SER A 1 176 ? -2.141  -14.518 12.245  1.000 36.913  ? 176 SER A CA    1 ? 
ATOM   1366 C  C     . SER A 1 176 ? -1.553  -15.203 13.480  1.000 34.714  ? 176 SER A C     1 ? 
ATOM   1367 O  O     . SER A 1 176 ? -0.757  -16.127 13.309  1.000 33.542  ? 176 SER A O     1 ? 
ATOM   1368 C  CB    . SER A 1 176 ? -3.539  -15.017 11.975  1.000 41.811  ? 176 SER A CB    1 ? 
ATOM   1369 O  OG    . SER A 1 176 ? -3.501  -16.261 11.266  1.000 45.053  ? 176 SER A OG    1 ? 
ATOM   1370 N  N     . GLY A 1 177 ? -2.005  -14.794 14.664  1.000 36.532  ? 177 GLY A N     1 ? 
ATOM   1371 C  CA    . GLY A 1 177 ? -1.537  -15.287 15.972  1.000 40.237  ? 177 GLY A CA    1 ? 
ATOM   1372 C  C     . GLY A 1 177 ? -0.023  -15.333 16.056  1.000 38.491  ? 177 GLY A C     1 ? 
ATOM   1373 O  O     . GLY A 1 177 ? 0.611   -14.251 15.967  1.000 38.760  ? 177 GLY A O     1 ? 
ATOM   1374 N  N     . ASP A 1 178 ? 0.530   -16.545 16.173  1.000 34.772  ? 178 ASP A N     1 ? 
ATOM   1375 C  CA    . ASP A 1 178 ? 1.924   -16.807 16.619  1.000 30.538  ? 178 ASP A CA    1 ? 
ATOM   1376 C  C     . ASP A 1 178 ? 2.810   -17.079 15.404  1.000 27.055  ? 178 ASP A C     1 ? 
ATOM   1377 O  O     . ASP A 1 178 ? 4.025   -17.075 15.561  1.000 28.632  ? 178 ASP A O     1 ? 
ATOM   1378 C  CB    . ASP A 1 178 ? 1.967   -17.973 17.616  1.000 29.848  ? 178 ASP A CB    1 ? 
ATOM   1379 C  CG    . ASP A 1 178 ? 1.327   -17.659 18.953  1.000 29.859  ? 178 ASP A CG    1 ? 
ATOM   1380 O  OD1   . ASP A 1 178 ? 1.481   -16.512 19.448  1.000 27.589  ? 178 ASP A OD1   1 ? 
ATOM   1381 O  OD2   . ASP A 1 178 ? 0.700   -18.564 19.500  1.000 35.135  ? 178 ASP A OD2   1 ? 
ATOM   1382 N  N     . ASP A 1 179 ? 2.219   -17.415 14.263  1.000 27.099  ? 179 ASP A N     1 ? 
ATOM   1383 C  CA    . ASP A 1 179 ? 2.937   -17.464 12.958  1.000 28.847  ? 179 ASP A CA    1 ? 
ATOM   1384 C  C     . ASP A 1 179 ? 3.275   -16.011 12.559  1.000 26.560  ? 179 ASP A C     1 ? 
ATOM   1385 O  O     . ASP A 1 179 ? 4.421   -15.753 12.134  1.000 25.778  ? 179 ASP A O     1 ? 
ATOM   1386 C  CB    . ASP A 1 179 ? 2.118   -18.250 11.927  1.000 30.374  ? 179 ASP A CB    1 ? 
ATOM   1387 C  CG    . ASP A 1 179 ? 2.177   -19.763 12.139  1.000 34.601  ? 179 ASP A CG    1 ? 
ATOM   1388 O  OD1   . ASP A 1 179 ? 2.632   -20.188 13.248  1.000 30.950  ? 179 ASP A OD1   1 ? 
ATOM   1389 O  OD2   . ASP A 1 179 ? 1.823   -20.523 11.181  1.000 31.114  ? 179 ASP A OD2   1 ? 
ATOM   1390 N  N     . ALA A 1 180 ? 2.341   -15.081 12.781  1.000 24.428  ? 180 ALA A N     1 ? 
ATOM   1391 C  CA    . ALA A 1 180 ? 2.505   -13.627 12.528  1.000 24.104  ? 180 ALA A CA    1 ? 
ATOM   1392 C  C     . ALA A 1 180 ? 3.533   -13.094 13.512  1.000 24.323  ? 180 ALA A C     1 ? 
ATOM   1393 O  O     . ALA A 1 180 ? 4.494   -12.428 13.079  1.000 28.860  ? 180 ALA A O     1 ? 
ATOM   1394 C  CB    . ALA A 1 180 ? 1.184   -12.898 12.683  1.000 23.140  ? 180 ALA A CB    1 ? 
ATOM   1395 N  N     . ALA A 1 181 ? 3.364   -13.441 14.787  1.000 23.223  ? 181 ALA A N     1 ? 
ATOM   1396 C  CA    . ALA A 1 181 ? 4.266   -13.032 15.875  1.000 23.445  ? 181 ALA A CA    1 ? 
ATOM   1397 C  C     . ALA A 1 181 ? 5.700   -13.445 15.529  1.000 19.652  ? 181 ALA A C     1 ? 
ATOM   1398 O  O     . ALA A 1 181 ? 6.576   -12.679 15.821  1.000 18.664  ? 181 ALA A O     1 ? 
ATOM   1399 C  CB    . ALA A 1 181 ? 3.797   -13.608 17.188  1.000 24.958  ? 181 ALA A CB    1 ? 
ATOM   1400 N  N     . GLN A 1 182 ? 5.912   -14.601 14.898  1.000 21.254  ? 182 GLN A N     1 ? 
ATOM   1401 C  CA    . GLN A 1 182 ? 7.283   -15.063 14.538  1.000 21.788  ? 182 GLN A CA    1 ? 
ATOM   1402 C  C     . GLN A 1 182 ? 7.799   -14.164 13.428  1.000 19.755  ? 182 GLN A C     1 ? 
ATOM   1403 O  O     . GLN A 1 182 ? 8.940   -13.723 13.507  1.000 18.021  ? 182 GLN A O     1 ? 
ATOM   1404 C  CB    . GLN A 1 182 ? 7.349   -16.520 14.073  1.000 24.606  ? 182 GLN A CB    1 ? 
ATOM   1405 C  CG    . GLN A 1 182 ? 8.787   -17.033 14.008  1.000 26.282  ? 182 GLN A CG    1 ? 
ATOM   1406 C  CD    . GLN A 1 182 ? 8.952   -18.506 13.679  1.000 31.193  ? 182 GLN A CD    1 ? 
ATOM   1407 O  OE1   . GLN A 1 182 ? 9.613   -19.258 14.411  1.000 31.410  ? 182 GLN A OE1   1 ? 
ATOM   1408 N  NE2   . GLN A 1 182 ? 8.420   -18.923 12.538  1.000 27.676  ? 182 GLN A NE2   1 ? 
ATOM   1409 N  N     . PHE A 1 183 ? 6.951   -13.912 12.431  1.000 19.092  ? 183 PHE A N     1 ? 
ATOM   1410 C  CA    . PHE A 1 183 ? 7.244   -13.034 11.285  1.000 16.497  ? 183 PHE A CA    1 ? 
ATOM   1411 C  C     . PHE A 1 183 ? 7.699   -11.666 11.818  1.000 15.655  ? 183 PHE A C     1 ? 
ATOM   1412 O  O     . PHE A 1 183 ? 8.736   -11.178 11.386  1.000 14.373  ? 183 PHE A O     1 ? 
ATOM   1413 C  CB    . PHE A 1 183 ? 6.017   -12.995 10.373  1.000 17.267  ? 183 PHE A CB    1 ? 
ATOM   1414 C  CG    . PHE A 1 183 ? 5.973   -11.883 9.359   1.000 15.502  ? 183 PHE A CG    1 ? 
ATOM   1415 C  CD1   . PHE A 1 183 ? 6.801   -11.905 8.258   1.000 16.061  ? 183 PHE A CD1   1 ? 
ATOM   1416 C  CD2   . PHE A 1 183 ? 5.068   -10.843 9.481   1.000 15.520  ? 183 PHE A CD2   1 ? 
ATOM   1417 C  CE1   . PHE A 1 183 ? 6.715   -10.917 7.287   1.000 14.995  ? 183 PHE A CE1   1 ? 
ATOM   1418 C  CE2   . PHE A 1 183 ? 4.970   -9.873  8.499   1.000 14.658  ? 183 PHE A CE2   1 ? 
ATOM   1419 C  CZ    . PHE A 1 183 ? 5.792   -9.922  7.400   1.000 14.420  ? 183 PHE A CZ    1 ? 
ATOM   1420 N  N     . ARG A 1 184 ? 6.964   -11.088 12.767  1.000 15.688  ? 184 ARG A N     1 ? 
ATOM   1421 C  CA    . ARG A 1 184 ? 7.283   -9.750  13.313  1.000 16.263  ? 184 ARG A CA    1 ? 
ATOM   1422 C  C     . ARG A 1 184 ? 8.604   -9.802  14.082  1.000 15.813  ? 184 ARG A C     1 ? 
ATOM   1423 O  O     . ARG A 1 184 ? 9.395   -8.868  13.913  1.000 15.024  ? 184 ARG A O     1 ? 
ATOM   1424 C  CB    . ARG A 1 184 ? 6.153   -9.193  14.188  1.000 17.410  ? 184 ARG A CB    1 ? 
ATOM   1425 C  CG    . ARG A 1 184 ? 4.990   -8.648  13.386  1.000 19.843  ? 184 ARG A CG    1 ? 
ATOM   1426 C  CD    . ARG A 1 184 ? 3.946   -7.954  14.243  1.000 22.735  ? 184 ARG A CD    1 ? 
ATOM   1427 N  NE    . ARG A 1 184 ? 3.380   -8.795  15.283  1.000 24.525  ? 184 ARG A NE    1 ? 
ATOM   1428 C  CZ    . ARG A 1 184 ? 2.327   -9.607  15.124  1.000 28.407  ? 184 ARG A CZ    1 ? 
ATOM   1429 N  NH1   . ARG A 1 184 ? 1.737   -9.729  13.943  1.000 28.828  ? 184 ARG A NH1   1 ? 
ATOM   1430 N  NH2   . ARG A 1 184 ? 1.866   -10.297 16.157  1.000 28.771  ? 184 ARG A NH2   1 ? 
ATOM   1431 N  N     . ARG A 1 185 ? 8.856   -10.851 14.875  1.000 15.168  ? 185 ARG A N     1 ? 
ATOM   1432 C  CA    . ARG A 1 185 ? 10.125  -10.963 15.633  1.000 15.587  ? 185 ARG A CA    1 ? 
ATOM   1433 C  C     . ARG A 1 185 ? 11.288  -10.987 14.644  1.000 14.467  ? 185 ARG A C     1 ? 
ATOM   1434 O  O     . ARG A 1 185 ? 12.285  -10.320 14.907  1.000 15.629  ? 185 ARG A O     1 ? 
ATOM   1435 C  CB    . ARG A 1 185 ? 10.155  -12.172 16.577  1.000 16.079  ? 185 ARG A CB    1 ? 
ATOM   1436 C  CG    . ARG A 1 185 ? 9.182   -12.087 17.737  1.000 16.211  ? 185 ARG A CG    1 ? 
ATOM   1437 C  CD    . ARG A 1 185 ? 9.562   -13.048 18.855  1.000 17.491  ? 185 ARG A CD    1 ? 
ATOM   1438 N  NE    . ARG A 1 185 ? 9.516   -14.436 18.419  1.000 16.565  ? 185 ARG A NE    1 ? 
ATOM   1439 C  CZ    . ARG A 1 185 ? 8.400   -15.144 18.184  1.000 18.219  ? 185 ARG A CZ    1 ? 
ATOM   1440 N  NH1   . ARG A 1 185 ? 7.193   -14.597 18.321  1.000 18.956  ? 185 ARG A NH1   1 ? 
ATOM   1441 N  NH2   . ARG A 1 185 ? 8.503   -16.404 17.789  1.000 17.785  ? 185 ARG A NH2   1 ? 
ATOM   1442 N  N     . CYS A 1 186 ? 11.145  -11.654 13.515  1.000 15.670  ? 186 CYS A N     1 ? 
ATOM   1443 C  CA    . CYS A 1 186 ? 12.258  -11.867 12.556  1.000 16.571  ? 186 CYS A CA    1 ? 
ATOM   1444 C  C     . CYS A 1 186 ? 12.601  -10.562 11.810  1.000 14.839  ? 186 CYS A C     1 ? 
ATOM   1445 O  O     . CYS A 1 186 ? 13.787  -10.318 11.568  1.000 14.723  ? 186 CYS A O     1 ? 
ATOM   1446 C  CB    . CYS A 1 186 ? 11.945  -13.010 11.607  1.000 18.755  ? 186 CYS A CB    1 ? 
ATOM   1447 S  SG    . CYS A 1 186 ? 12.163  -14.627 12.389  1.000 22.824  ? 186 CYS A SG    1 ? 
ATOM   1448 N  N     . ILE A 1 187 ? 11.607  -9.762  11.451  1.000 13.814  ? 187 ILE A N     1 ? 
ATOM   1449 C  CA    . ILE A 1 187 ? 11.795  -8.380  10.915  1.000 13.441  ? 187 ILE A CA    1 ? 
ATOM   1450 C  C     . ILE A 1 187 ? 12.615  -7.557  11.941  1.000 12.059  ? 187 ILE A C     1 ? 
ATOM   1451 O  O     . ILE A 1 187 ? 13.622  -6.958  11.574  1.000 10.417  ? 187 ILE A O     1 ? 
ATOM   1452 C  CB    . ILE A 1 187 ? 10.413  -7.749  10.584  1.000 14.678  ? 187 ILE A CB    1 ? 
ATOM   1453 C  CG1   . ILE A 1 187 ? 9.727   -8.399  9.367   1.000 15.618  ? 187 ILE A CG1   1 ? 
ATOM   1454 C  CG2   . ILE A 1 187 ? 10.539  -6.231  10.400  1.000 15.510  ? 187 ILE A CG2   1 ? 
ATOM   1455 C  CD1   . ILE A 1 187 ? 8.213   -8.049  9.204   1.000 15.240  ? 187 ILE A CD1   1 ? 
ATOM   1456 N  N     . ARG A 1 188 ? 12.246  -7.587  13.231  1.000 12.358  ? 188 ARG A N     1 ? 
ATOM   1457 C  CA    . ARG A 1 188 ? 12.933  -6.780  14.279  1.000 12.050  ? 188 ARG A CA    1 ? 
ATOM   1458 C  C     . ARG A 1 188 ? 14.381  -7.245  14.427  1.000 11.140  ? 188 ARG A C     1 ? 
ATOM   1459 O  O     . ARG A 1 188 ? 15.246  -6.397  14.430  1.000 10.482  ? 188 ARG A O     1 ? 
ATOM   1460 C  CB    . ARG A 1 188 ? 12.226  -6.890  15.626  1.000 14.035  ? 188 ARG A CB    1 ? 
ATOM   1461 C  CG    . ARG A 1 188 ? 10.826  -6.324  15.639  1.000 16.300  ? 188 ARG A CG    1 ? 
ATOM   1462 C  CD    . ARG A 1 188 ? 10.360  -6.223  17.077  1.000 19.179  ? 188 ARG A CD    1 ? 
ATOM   1463 N  NE    . ARG A 1 188 ? 9.376   -5.180  17.177  1.000 20.579  ? 188 ARG A NE    1 ? 
ATOM   1464 C  CZ    . ARG A 1 188 ? 8.085   -5.388  17.373  1.000 23.701  ? 188 ARG A CZ    1 ? 
ATOM   1465 N  NH1   . ARG A 1 188 ? 7.602   -6.617  17.489  1.000 23.033  ? 188 ARG A NH1   1 ? 
ATOM   1466 N  NH2   . ARG A 1 188 ? 7.277   -4.345  17.457  1.000 26.898  ? 188 ARG A NH2   1 ? 
ATOM   1467 N  N     . TYR A 1 189 ? 14.632  -8.556  14.494  1.000 11.095  ? 189 TYR A N     1 ? 
ATOM   1468 C  CA    . TYR A 1 189 ? 15.995  -9.143  14.524  1.000 12.222  ? 189 TYR A CA    1 ? 
ATOM   1469 C  C     . TYR A 1 189 ? 16.861  -8.558  13.402  1.000 12.829  ? 189 TYR A C     1 ? 
ATOM   1470 O  O     . TYR A 1 189 ? 18.021  -8.136  13.663  1.000 14.333  ? 189 TYR A O     1 ? 
ATOM   1471 C  CB    . TYR A 1 189 ? 15.982  -10.668 14.339  1.000 12.522  ? 189 TYR A CB    1 ? 
ATOM   1472 C  CG    . TYR A 1 189 ? 15.250  -11.450 15.392  1.000 11.854  ? 189 TYR A CG    1 ? 
ATOM   1473 C  CD1   . TYR A 1 189 ? 15.270  -11.058 16.719  1.000 12.327  ? 189 TYR A CD1   1 ? 
ATOM   1474 C  CD2   . TYR A 1 189 ? 14.553  -12.606 15.069  1.000 11.125  ? 189 TYR A CD2   1 ? 
ATOM   1475 C  CE1   . TYR A 1 189 ? 14.620  -11.793 17.704  1.000 11.998  ? 189 TYR A CE1   1 ? 
ATOM   1476 C  CE2   . TYR A 1 189 ? 13.887  -13.336 16.029  1.000 11.039  ? 189 TYR A CE2   1 ? 
ATOM   1477 C  CZ    . TYR A 1 189 ? 13.933  -12.937 17.354  1.000 11.819  ? 189 TYR A CZ    1 ? 
ATOM   1478 O  OH    . TYR A 1 189 ? 13.262  -13.622 18.317  1.000 11.648  ? 189 TYR A OH    1 ? 
ATOM   1479 N  N     . LEU A 1 190 ? 16.345  -8.529  12.173  1.000 14.111  ? 190 LEU A N     1 ? 
ATOM   1480 C  CA    . LEU A 1 190 ? 17.128  -8.067  10.999  1.000 14.852  ? 190 LEU A CA    1 ? 
ATOM   1481 C  C     . LEU A 1 190 ? 17.256  -6.532  10.996  1.000 16.140  ? 190 LEU A C     1 ? 
ATOM   1482 O  O     . LEU A 1 190 ? 18.218  -6.041  10.422  1.000 16.594  ? 190 LEU A O     1 ? 
ATOM   1483 C  CB    . LEU A 1 190 ? 16.469  -8.573  9.720   1.000 15.392  ? 190 LEU A CB    1 ? 
ATOM   1484 C  CG    . LEU A 1 190 ? 16.591  -10.074 9.469   1.000 16.843  ? 190 LEU A CG    1 ? 
ATOM   1485 C  CD1   . LEU A 1 190 ? 15.789  -10.469 8.244   1.000 17.157  ? 190 LEU A CD1   1 ? 
ATOM   1486 C  CD2   . LEU A 1 190 ? 18.050  -10.511 9.303   1.000 18.224  ? 190 LEU A CD2   1 ? 
ATOM   1487 N  N     . LYS A 1 191 ? 16.316  -5.806  11.588  1.000 16.688  ? 191 LYS A N     1 ? 
ATOM   1488 C  CA    . LYS A 1 191 ? 16.439  -4.351  11.766  1.000 18.752  ? 191 LYS A CA    1 ? 
ATOM   1489 C  C     . LYS A 1 191 ? 17.589  -4.019  12.717  1.000 19.414  ? 191 LYS A C     1 ? 
ATOM   1490 O  O     . LYS A 1 191 ? 18.359  -3.127  12.385  1.000 17.475  ? 191 LYS A O     1 ? 
ATOM   1491 C  CB    . LYS A 1 191 ? 15.108  -3.776  12.244  1.000 20.767  ? 191 LYS A CB    1 ? 
ATOM   1492 C  CG    . LYS A 1 191 ? 14.124  -3.591  11.100  1.000 20.571  ? 191 LYS A CG    1 ? 
ATOM   1493 C  CD    . LYS A 1 191 ? 12.756  -3.258  11.528  1.000 21.521  ? 191 LYS A CD    1 ? 
ATOM   1494 C  CE    . LYS A 1 191 ? 11.944  -2.846  10.328  1.000 22.226  ? 191 LYS A CE    1 ? 
ATOM   1495 N  NZ    . LYS A 1 191 ? 10.726  -2.167  10.762  1.000 23.454  ? 191 LYS A NZ    1 ? 
ATOM   1496 N  N     . ARG A 1 192 ? 17.680  -4.689  13.865  1.000 21.223  ? 192 ARG A N     1 ? 
ATOM   1497 C  CA    . ARG A 1 192 ? 18.791  -4.461  14.827  1.000 20.773  ? 192 ARG A CA    1 ? 
ATOM   1498 C  C     . ARG A 1 192 ? 20.106  -4.834  14.131  1.000 22.654  ? 192 ARG A C     1 ? 
ATOM   1499 O  O     . ARG A 1 192 ? 21.102  -4.055  14.287  1.000 22.726  ? 192 ARG A O     1 ? 
ATOM   1500 C  CB    . ARG A 1 192 ? 18.597  -5.254  16.119  1.000 20.166  ? 192 ARG A CB    1 ? 
ATOM   1501 C  CG    . ARG A 1 192 ? 19.770  -5.174  17.104  1.000 19.711  ? 192 ARG A CG    1 ? 
ATOM   1502 C  CD    . ARG A 1 192 ? 20.296  -3.778  17.326  1.000 19.226  ? 192 ARG A CD    1 ? 
ATOM   1503 N  NE    . ARG A 1 192 ? 19.275  -2.973  17.975  1.000 19.278  ? 192 ARG A NE    1 ? 
ATOM   1504 C  CZ    . ARG A 1 192 ? 19.052  -2.973  19.297  1.000 19.387  ? 192 ARG A CZ    1 ? 
ATOM   1505 N  NH1   . ARG A 1 192 ? 19.819  -3.708  20.076  1.000 17.745  ? 192 ARG A NH1   1 ? 
ATOM   1506 N  NH2   . ARG A 1 192 ? 18.069  -2.239  19.823  1.000 18.807  ? 192 ARG A NH2   1 ? 
ATOM   1507 N  N     . TRP A 1 193 ? 20.119  -5.944  13.379  1.000 21.108  ? 193 TRP A N     1 ? 
ATOM   1508 C  CA    . TRP A 1 193 ? 21.267  -6.326  12.505  1.000 22.623  ? 193 TRP A CA    1 ? 
ATOM   1509 C  C     . TRP A 1 193 ? 21.625  -5.162  11.566  1.000 22.094  ? 193 TRP A C     1 ? 
ATOM   1510 O  O     . TRP A 1 193 ? 22.795  -4.817  11.494  1.000 21.896  ? 193 TRP A O     1 ? 
ATOM   1511 C  CB    . TRP A 1 193 ? 20.987  -7.612  11.728  1.000 22.080  ? 193 TRP A CB    1 ? 
ATOM   1512 C  CG    . TRP A 1 193 ? 21.966  -7.827  10.617  1.000 24.264  ? 193 TRP A CG    1 ? 
ATOM   1513 C  CD1   . TRP A 1 193 ? 23.290  -8.139  10.733  1.000 24.942  ? 193 TRP A CD1   1 ? 
ATOM   1514 C  CD2   . TRP A 1 193 ? 21.712  -7.679  9.204   1.000 23.843  ? 193 TRP A CD2   1 ? 
ATOM   1515 N  NE1   . TRP A 1 193 ? 23.861  -8.245  9.491   1.000 26.091  ? 193 TRP A NE1   1 ? 
ATOM   1516 C  CE2   . TRP A 1 193 ? 22.926  -7.954  8.534   1.000 24.287  ? 193 TRP A CE2   1 ? 
ATOM   1517 C  CE3   . TRP A 1 193 ? 20.582  -7.357  8.442   1.000 20.621  ? 193 TRP A CE3   1 ? 
ATOM   1518 C  CZ2   . TRP A 1 193 ? 23.046  -7.880  7.145   1.000 23.505  ? 193 TRP A CZ2   1 ? 
ATOM   1519 C  CZ3   . TRP A 1 193 ? 20.696  -7.312  7.071   1.000 23.182  ? 193 TRP A CZ3   1 ? 
ATOM   1520 C  CH2   . TRP A 1 193 ? 21.914  -7.561  6.433   1.000 22.544  ? 193 TRP A CH2   1 ? 
ATOM   1521 N  N     . ARG A 1 194 ? 20.648  -4.569  10.903  1.000 23.388  ? 194 ARG A N     1 ? 
ATOM   1522 C  CA    . ARG A 1 194 ? 20.850  -3.404  9.993   1.000 27.939  ? 194 ARG A CA    1 ? 
ATOM   1523 C  C     . ARG A 1 194 ? 21.474  -2.233  10.786  1.000 31.378  ? 194 ARG A C     1 ? 
ATOM   1524 O  O     . ARG A 1 194 ? 22.396  -1.495  10.220  1.000 26.263  ? 194 ARG A O     1 ? 
ATOM   1525 C  CB    . ARG A 1 194 ? 19.516  -2.966  9.377   1.000 25.415  ? 194 ARG A CB    1 ? 
ATOM   1526 C  CG    . ARG A 1 194 ? 19.610  -1.663  8.593   1.000 26.823  ? 194 ARG A CG    1 ? 
ATOM   1527 C  CD    . ARG A 1 194 ? 18.356  -0.804  8.655   1.000 28.389  ? 194 ARG A CD    1 ? 
ATOM   1528 N  NE    . ARG A 1 194 ? 17.880  -0.584  10.022  1.000 27.027  ? 194 ARG A NE    1 ? 
ATOM   1529 C  CZ    . ARG A 1 194 ? 16.650  -0.186  10.347  1.000 27.415  ? 194 ARG A CZ    1 ? 
ATOM   1530 N  NH1   . ARG A 1 194 ? 15.764  0.044   9.397   1.000 27.693  ? 194 ARG A NH1   1 ? 
ATOM   1531 N  NH2   . ARG A 1 194 ? 16.309  -0.009  11.619  1.000 27.821  ? 194 ARG A NH2   1 ? 
ATOM   1532 N  N     . ASP A 1 195 ? 20.929  -1.988  11.988  1.000 29.596  ? 195 ASP A N     1 ? 
ATOM   1533 C  CA    . ASP A 1 195 ? 21.286  -0.838  12.861  1.000 30.973  ? 195 ASP A CA    1 ? 
ATOM   1534 C  C     . ASP A 1 195 ? 22.704  -1.053  13.369  1.000 28.172  ? 195 ASP A C     1 ? 
ATOM   1535 O  O     . ASP A 1 195 ? 23.457  -0.046  13.515  1.000 32.596  ? 195 ASP A O     1 ? 
ATOM   1536 C  CB    . ASP A 1 195 ? 20.280  -0.657  14.009  1.000 30.681  ? 195 ASP A CB    1 ? 
ATOM   1537 C  CG    . ASP A 1 195 ? 19.015  0.049   13.548  1.000 33.336  ? 195 ASP A CG    1 ? 
ATOM   1538 O  OD1   . ASP A 1 195 ? 19.031  0.557   12.392  1.000 35.667  ? 195 ASP A OD1   1 ? 
ATOM   1539 O  OD2   . ASP A 1 195 ? 18.009  0.076   14.329  1.000 33.793  ? 195 ASP A OD2   1 ? 
ATOM   1540 N  N     . PHE A 1 196 ? 23.075  -2.308  13.575  1.000 25.290  ? 196 PHE A N     1 ? 
ATOM   1541 C  CA    . PHE A 1 196 ? 24.397  -2.668  14.112  1.000 27.038  ? 196 PHE A CA    1 ? 
ATOM   1542 C  C     . PHE A 1 196 ? 25.489  -2.615  13.035  1.000 30.878  ? 196 PHE A C     1 ? 
ATOM   1543 O  O     . PHE A 1 196 ? 26.627  -2.249  13.412  1.000 30.689  ? 196 PHE A O     1 ? 
ATOM   1544 C  CB    . PHE A 1 196 ? 24.373  -4.036  14.779  1.000 25.992  ? 196 PHE A CB    1 ? 
ATOM   1545 C  CG    . PHE A 1 196 ? 25.655  -4.325  15.507  1.000 26.001  ? 196 PHE A CG    1 ? 
ATOM   1546 C  CD1   . PHE A 1 196 ? 26.175  -3.403  16.407  1.000 29.183  ? 196 PHE A CD1   1 ? 
ATOM   1547 C  CD2   . PHE A 1 196 ? 26.366  -5.488  15.272  1.000 28.318  ? 196 PHE A CD2   1 ? 
ATOM   1548 C  CE1   . PHE A 1 196 ? 27.355  -3.664  17.084  1.000 28.629  ? 196 PHE A CE1   1 ? 
ATOM   1549 C  CE2   . PHE A 1 196 ? 27.560  -5.733  15.927  1.000 29.201  ? 196 PHE A CE2   1 ? 
ATOM   1550 C  CZ    . PHE A 1 196 ? 28.044  -4.822  16.842  1.000 30.704  ? 196 PHE A CZ    1 ? 
ATOM   1551 N  N     . ARG A 1 197 ? 25.213  -3.036  11.784  1.000 34.475  ? 197 ARG A N     1 ? 
ATOM   1552 C  CA    . ARG A 1 197 ? 26.297  -3.409  10.820  1.000 32.390  ? 197 ARG A CA    1 ? 
ATOM   1553 C  C     . ARG A 1 197 ? 26.190  -2.595  9.539   1.000 32.038  ? 197 ARG A C     1 ? 
ATOM   1554 O  O     . ARG A 1 197 ? 27.013  -2.804  8.671   1.000 32.381  ? 197 ARG A O     1 ? 
ATOM   1555 C  CB    . ARG A 1 197 ? 26.331  -4.921  10.601  1.000 32.142  ? 197 ARG A CB    1 ? 
ATOM   1556 C  CG    . ARG A 1 197 ? 26.945  -5.653  11.781  1.000 36.135  ? 197 ARG A CG    1 ? 
ATOM   1557 C  CD    . ARG A 1 197 ? 27.409  -7.070  11.485  1.000 41.844  ? 197 ARG A CD    1 ? 
ATOM   1558 N  NE    . ARG A 1 197 ? 28.641  -7.174  10.699  1.000 49.259  ? 197 ARG A NE    1 ? 
ATOM   1559 C  CZ    . ARG A 1 197 ? 29.531  -8.187  10.774  1.000 51.459  ? 197 ARG A CZ    1 ? 
ATOM   1560 N  NH1   . ARG A 1 197 ? 29.378  -9.170  11.644  1.000 46.886  ? 197 ARG A NH1   1 ? 
ATOM   1561 N  NH2   . ARG A 1 197 ? 30.592  -8.200  9.983   1.000 55.396  ? 197 ARG A NH2   1 ? 
ATOM   1562 N  N     . PHE A 1 198 ? 25.254  -1.652  9.497   1.000 32.766  ? 198 PHE A N     1 ? 
ATOM   1563 C  CA    . PHE A 1 198 ? 25.184  -0.519  8.555   1.000 31.838  ? 198 PHE A CA    1 ? 
ATOM   1564 C  C     . PHE A 1 198 ? 24.946  0.752   9.381   1.000 32.859  ? 198 PHE A C     1 ? 
ATOM   1565 O  O     . PHE A 1 198 ? 25.142  1.844   8.818   1.000 38.205  ? 198 PHE A O     1 ? 
ATOM   1566 C  CB    . PHE A 1 198 ? 24.072  -0.728  7.518   1.000 31.436  ? 198 PHE A CB    1 ? 
ATOM   1567 C  CG    . PHE A 1 198 ? 24.014  -2.090  6.873   1.000 28.650  ? 198 PHE A CG    1 ? 
ATOM   1568 C  CD1   . PHE A 1 198 ? 23.773  -3.227  7.621   1.000 27.941  ? 198 PHE A CD1   1 ? 
ATOM   1569 C  CD2   . PHE A 1 198 ? 24.165  -2.232  5.498   1.000 29.985  ? 198 PHE A CD2   1 ? 
ATOM   1570 C  CE1   . PHE A 1 198 ? 23.719  -4.478  7.024   1.000 29.131  ? 198 PHE A CE1   1 ? 
ATOM   1571 C  CE2   . PHE A 1 198 ? 24.130  -3.487  4.906   1.000 30.120  ? 198 PHE A CE2   1 ? 
ATOM   1572 C  CZ    . PHE A 1 198 ? 23.894  -4.610  5.668   1.000 28.072  ? 198 PHE A CZ    1 ? 
ATOM   1573 N  N     . PRO A 1 206 ? 20.260  -1.830  3.476   1.000 65.572  ? 206 PRO A N     1 ? 
ATOM   1574 C  CA    . PRO A 1 206 ? 19.135  -2.749  3.494   1.000 60.665  ? 206 PRO A CA    1 ? 
ATOM   1575 C  C     . PRO A 1 206 ? 17.918  -2.059  4.120   1.000 58.581  ? 206 PRO A C     1 ? 
ATOM   1576 O  O     . PRO A 1 206 ? 17.345  -2.606  5.065   1.000 73.017  ? 206 PRO A O     1 ? 
ATOM   1577 C  CB    . PRO A 1 206 ? 19.639  -3.925  4.354   1.000 62.382  ? 206 PRO A CB    1 ? 
ATOM   1578 C  CG    . PRO A 1 206 ? 21.060  -3.534  4.782   1.000 64.247  ? 206 PRO A CG    1 ? 
ATOM   1579 C  CD    . PRO A 1 206 ? 21.188  -2.036  4.563   1.000 64.490  ? 206 PRO A CD    1 ? 
ATOM   1580 N  N     . LEU A 1 207 ? 17.592  -0.864  3.611   1.000 49.594  ? 207 LEU A N     1 ? 
ATOM   1581 C  CA    . LEU A 1 207 ? 16.409  -0.053  4.009   1.000 46.627  ? 207 LEU A CA    1 ? 
ATOM   1582 C  C     . LEU A 1 207 ? 15.396  -0.985  4.684   1.000 39.815  ? 207 LEU A C     1 ? 
ATOM   1583 O  O     . LEU A 1 207 ? 15.179  -2.085  4.146   1.000 36.325  ? 207 LEU A O     1 ? 
ATOM   1584 C  CB    . LEU A 1 207 ? 15.831  0.615   2.761   1.000 49.985  ? 207 LEU A CB    1 ? 
ATOM   1585 C  CG    . LEU A 1 207 ? 16.863  1.046   1.711   1.000 60.873  ? 207 LEU A CG    1 ? 
ATOM   1586 C  CD1   . LEU A 1 207 ? 16.189  1.740   0.530   1.000 63.016  ? 207 LEU A CD1   1 ? 
ATOM   1587 C  CD2   . LEU A 1 207 ? 17.939  1.952   2.318   1.000 59.066  ? 207 LEU A CD2   1 ? 
ATOM   1588 N  N     . GLY A 1 208 ? 14.918  -0.631  5.880   1.000 34.867  ? 208 GLY A N     1 ? 
ATOM   1589 C  CA    . GLY A 1 208 ? 14.099  -1.526  6.730   1.000 30.507  ? 208 GLY A CA    1 ? 
ATOM   1590 C  C     . GLY A 1 208 ? 12.868  -2.010  5.987   1.000 27.114  ? 208 GLY A C     1 ? 
ATOM   1591 O  O     . GLY A 1 208 ? 12.443  -3.149  6.229   1.000 25.829  ? 208 GLY A O     1 ? 
ATOM   1592 N  N     . ILE A 1 209 ? 12.317  -1.146  5.131   1.000 26.017  ? 209 ILE A N     1 ? 
ATOM   1593 C  CA    . ILE A 1 209 ? 11.267  -1.436  4.099   1.000 27.588  ? 209 ILE A CA    1 ? 
ATOM   1594 C  C     . ILE A 1 209 ? 11.723  -2.599  3.200   1.000 24.135  ? 209 ILE A C     1 ? 
ATOM   1595 O  O     . ILE A 1 209 ? 10.940  -3.561  3.005   1.000 24.377  ? 209 ILE A O     1 ? 
ATOM   1596 C  CB    . ILE A 1 209 ? 10.971  -0.140  3.305   1.000 30.400  ? 209 ILE A CB    1 ? 
ATOM   1597 C  CG1   . ILE A 1 209 ? 9.941   -0.348  2.198   1.000 31.016  ? 209 ILE A CG1   1 ? 
ATOM   1598 C  CG2   . ILE A 1 209 ? 12.262  0.483   2.764   1.000 33.737  ? 209 ILE A CG2   1 ? 
ATOM   1599 C  CD1   . ILE A 1 209 ? 8.536   -0.457  2.681   1.000 33.894  ? 209 ILE A CD1   1 ? 
ATOM   1600 N  N     . GLY A 1 210 ? 12.967  -2.552  2.723   1.000 23.778  ? 210 GLY A N     1 ? 
ATOM   1601 C  CA    . GLY A 1 210 ? 13.616  -3.631  1.951   1.000 21.213  ? 210 GLY A CA    1 ? 
ATOM   1602 C  C     . GLY A 1 210 ? 13.455  -4.981  2.613   1.000 20.460  ? 210 GLY A C     1 ? 
ATOM   1603 O  O     . GLY A 1 210 ? 12.894  -5.912  1.973   1.000 20.359  ? 210 GLY A O     1 ? 
ATOM   1604 N  N     . LEU A 1 211 ? 13.889  -5.098  3.867   1.000 19.096  ? 211 LEU A N     1 ? 
ATOM   1605 C  CA    . LEU A 1 211 ? 13.835  -6.365  4.623   1.000 16.829  ? 211 LEU A CA    1 ? 
ATOM   1606 C  C     . LEU A 1 211 ? 12.375  -6.723  4.893   1.000 14.005  ? 211 LEU A C     1 ? 
ATOM   1607 O  O     . LEU A 1 211 ? 12.047  -7.923  4.852   1.000 14.465  ? 211 LEU A O     1 ? 
ATOM   1608 C  CB    . LEU A 1 211 ? 14.629  -6.229  5.923   1.000 18.331  ? 211 LEU A CB    1 ? 
ATOM   1609 C  CG    . LEU A 1 211 ? 16.105  -5.873  5.770   1.000 20.180  ? 211 LEU A CG    1 ? 
ATOM   1610 C  CD1   . LEU A 1 211 ? 16.787  -5.809  7.127   1.000 21.010  ? 211 LEU A CD1   1 ? 
ATOM   1611 C  CD2   . LEU A 1 211 ? 16.835  -6.873  4.902   1.000 20.098  ? 211 LEU A CD2   1 ? 
ATOM   1612 N  N     . THR A 1 212 ? 11.529  -5.720  5.153   1.000 12.585  ? 212 THR A N     1 ? 
ATOM   1613 C  CA    . THR A 1 212 ? 10.085  -5.906  5.443   1.000 11.469  ? 212 THR A CA    1 ? 
ATOM   1614 C  C     . THR A 1 212 ? 9.398   -6.434  4.191   1.000 11.438  ? 212 THR A C     1 ? 
ATOM   1615 O  O     . THR A 1 212 ? 8.719   -7.483  4.294   1.000 12.919  ? 212 THR A O     1 ? 
ATOM   1616 C  CB    . THR A 1 212 ? 9.420   -4.657  6.035   1.000 10.879  ? 212 THR A CB    1 ? 
ATOM   1617 O  OG1   . THR A 1 212 ? 10.180  -4.289  7.183   1.000 10.369  ? 212 THR A OG1   1 ? 
ATOM   1618 C  CG2   . THR A 1 212 ? 7.981   -4.884  6.469   1.000 10.769  ? 212 THR A CG2   1 ? 
ATOM   1619 N  N     . ALA A 1 213 ? 9.618   -5.815  3.042   1.000 12.079  ? 213 ALA A N     1 ? 
ATOM   1620 C  CA    . ALA A 1 213 ? 9.059   -6.305  1.757   1.000 10.971  ? 213 ALA A CA    1 ? 
ATOM   1621 C  C     . ALA A 1 213 ? 9.627   -7.715  1.508   1.000 11.897  ? 213 ALA A C     1 ? 
ATOM   1622 O  O     . ALA A 1 213 ? 8.850   -8.680  1.277   1.000 10.424  ? 213 ALA A O     1 ? 
ATOM   1623 C  CB    . ALA A 1 213 ? 9.381   -5.340  0.655   1.000 10.755  ? 213 ALA A CB    1 ? 
ATOM   1624 N  N     . ALA A 1 214 ? 10.937  -7.881  1.656   1.000 13.510  ? 214 ALA A N     1 ? 
ATOM   1625 C  CA    . ALA A 1 214 ? 11.596  -9.189  1.437   1.000 14.224  ? 214 ALA A CA    1 ? 
ATOM   1626 C  C     . ALA A 1 214 ? 10.852  -10.264 2.226   1.000 14.295  ? 214 ALA A C     1 ? 
ATOM   1627 O  O     . ALA A 1 214 ? 10.466  -11.283 1.627   1.000 15.234  ? 214 ALA A O     1 ? 
ATOM   1628 C  CB    . ALA A 1 214 ? 13.042  -9.109  1.835   1.000 16.455  ? 214 ALA A CB    1 ? 
ATOM   1629 N  N     . ALA A 1 215 ? 10.582  -10.002 3.512   1.000 14.086  ? 215 ALA A N     1 ? 
ATOM   1630 C  CA    . ALA A 1 215 ? 9.966   -10.972 4.445   1.000 13.823  ? 215 ALA A CA    1 ? 
ATOM   1631 C  C     . ALA A 1 215 ? 8.534   -11.270 4.001   1.000 14.864  ? 215 ALA A C     1 ? 
ATOM   1632 O  O     . ALA A 1 215 ? 8.109   -12.433 4.102   1.000 13.920  ? 215 ALA A O     1 ? 
ATOM   1633 C  CB    . ALA A 1 215 ? 9.994   -10.458 5.873   1.000 13.141  ? 215 ALA A CB    1 ? 
ATOM   1634 N  N     . TYR A 1 216 ? 7.787   -10.243 3.607   1.000 15.395  ? 216 TYR A N     1 ? 
ATOM   1635 C  CA    . TYR A 1 216 ? 6.417   -10.424 3.086   1.000 16.689  ? 216 TYR A CA    1 ? 
ATOM   1636 C  C     . TYR A 1 216 ? 6.444   -11.500 1.991   1.000 15.408  ? 216 TYR A C     1 ? 
ATOM   1637 O  O     . TYR A 1 216 ? 5.614   -12.439 2.046   1.000 13.867  ? 216 TYR A O     1 ? 
ATOM   1638 C  CB    . TYR A 1 216 ? 5.830   -9.114  2.580   1.000 18.465  ? 216 TYR A CB    1 ? 
ATOM   1639 C  CG    . TYR A 1 216 ? 4.588   -9.339  1.769   1.000 19.997  ? 216 TYR A CG    1 ? 
ATOM   1640 C  CD1   . TYR A 1 216 ? 3.346   -9.505  2.368   1.000 21.125  ? 216 TYR A CD1   1 ? 
ATOM   1641 C  CD2   . TYR A 1 216 ? 4.683   -9.497  0.407   1.000 18.332  ? 216 TYR A CD2   1 ? 
ATOM   1642 C  CE1   . TYR A 1 216 ? 2.214   -9.739  1.608   1.000 18.952  ? 216 TYR A CE1   1 ? 
ATOM   1643 C  CE2   . TYR A 1 216 ? 3.569   -9.746  -0.358  1.000 19.636  ? 216 TYR A CE2   1 ? 
ATOM   1644 C  CZ    . TYR A 1 216 ? 2.338   -9.866  0.239   1.000 19.904  ? 216 TYR A CZ    1 ? 
ATOM   1645 O  OH    . TYR A 1 216 ? 1.273   -10.105 -0.574  1.000 24.007  ? 216 TYR A OH    1 ? 
ATOM   1646 N  N     . TRP A 1 217 ? 7.389   -11.403 1.069   1.000 15.052  ? 217 TRP A N     1 ? 
ATOM   1647 C  CA    . TRP A 1 217 ? 7.504   -12.320 -0.090  1.000 16.841  ? 217 TRP A CA    1 ? 
ATOM   1648 C  C     . TRP A 1 217 ? 8.030   -13.683 0.376   1.000 17.658  ? 217 TRP A C     1 ? 
ATOM   1649 O  O     . TRP A 1 217 ? 7.423   -14.706 0.023   1.000 18.624  ? 217 TRP A O     1 ? 
ATOM   1650 C  CB    . TRP A 1 217 ? 8.408   -11.731 -1.181  1.000 18.122  ? 217 TRP A CB    1 ? 
ATOM   1651 C  CG    . TRP A 1 217 ? 7.829   -10.556 -1.890  1.000 18.170  ? 217 TRP A CG    1 ? 
ATOM   1652 C  CD1   . TRP A 1 217 ? 8.348   -9.303  -1.955  1.000 18.832  ? 217 TRP A CD1   1 ? 
ATOM   1653 C  CD2   . TRP A 1 217 ? 6.584   -10.517 -2.613  1.000 20.072  ? 217 TRP A CD2   1 ? 
ATOM   1654 N  NE1   . TRP A 1 217 ? 7.520   -8.483  -2.677  1.000 19.054  ? 217 TRP A NE1   1 ? 
ATOM   1655 C  CE2   . TRP A 1 217 ? 6.429   -9.207  -3.099  1.000 19.752  ? 217 TRP A CE2   1 ? 
ATOM   1656 C  CE3   . TRP A 1 217 ? 5.596   -11.463 -2.916  1.000 21.066  ? 217 TRP A CE3   1 ? 
ATOM   1657 C  CZ2   . TRP A 1 217 ? 5.334   -8.829  -3.879  1.000 20.171  ? 217 TRP A CZ2   1 ? 
ATOM   1658 C  CZ3   . TRP A 1 217 ? 4.509   -11.082 -3.675  1.000 21.813  ? 217 TRP A CZ3   1 ? 
ATOM   1659 C  CH2   . TRP A 1 217 ? 4.378   -9.779  -4.142  1.000 19.922  ? 217 TRP A CH2   1 ? 
ATOM   1660 N  N     . TRP A 1 218 ? 9.117   -13.714 1.140   1.000 18.663  ? 218 TRP A N     1 ? 
ATOM   1661 C  CA    . TRP A 1 218 ? 9.966   -14.930 1.238   1.000 20.449  ? 218 TRP A CA    1 ? 
ATOM   1662 C  C     . TRP A 1 218 ? 9.889   -15.577 2.619   1.000 22.019  ? 218 TRP A C     1 ? 
ATOM   1663 O  O     . TRP A 1 218 ? 10.270  -16.758 2.715   1.000 22.635  ? 218 TRP A O     1 ? 
ATOM   1664 C  CB    . TRP A 1 218 ? 11.404  -14.597 0.820   1.000 18.796  ? 218 TRP A CB    1 ? 
ATOM   1665 C  CG    . TRP A 1 218 ? 11.505  -14.281 -0.639  1.000 18.913  ? 218 TRP A CG    1 ? 
ATOM   1666 C  CD1   . TRP A 1 218 ? 10.854  -14.907 -1.661  1.000 20.018  ? 218 TRP A CD1   1 ? 
ATOM   1667 C  CD2   . TRP A 1 218 ? 12.312  -13.261 -1.249  1.000 21.311  ? 218 TRP A CD2   1 ? 
ATOM   1668 N  NE1   . TRP A 1 218 ? 11.203  -14.353 -2.864  1.000 21.454  ? 218 TRP A NE1   1 ? 
ATOM   1669 C  CE2   . TRP A 1 218 ? 12.098  -13.345 -2.647  1.000 22.132  ? 218 TRP A CE2   1 ? 
ATOM   1670 C  CE3   . TRP A 1 218 ? 13.199  -12.293 -0.761  1.000 20.373  ? 218 TRP A CE3   1 ? 
ATOM   1671 C  CZ2   . TRP A 1 218 ? 12.741  -12.500 -3.548  1.000 22.674  ? 218 TRP A CZ2   1 ? 
ATOM   1672 C  CZ3   . TRP A 1 218 ? 13.824  -11.457 -1.654  1.000 21.505  ? 218 TRP A CZ3   1 ? 
ATOM   1673 C  CH2   . TRP A 1 218 ? 13.592  -11.554 -3.027  1.000 22.262  ? 218 TRP A CH2   1 ? 
ATOM   1674 N  N     . PHE A 1 219 ? 9.505   -14.847 3.664   1.000 21.862  ? 219 PHE A N     1 ? 
ATOM   1675 C  CA    . PHE A 1 219 ? 9.583   -15.385 5.044   1.000 22.637  ? 219 PHE A CA    1 ? 
ATOM   1676 C  C     . PHE A 1 219 ? 8.723   -16.633 5.121   1.000 21.998  ? 219 PHE A C     1 ? 
ATOM   1677 O  O     . PHE A 1 219 ? 7.582   -16.560 4.733   1.000 22.571  ? 219 PHE A O     1 ? 
ATOM   1678 C  CB    . PHE A 1 219 ? 9.115   -14.376 6.090   1.000 22.350  ? 219 PHE A CB    1 ? 
ATOM   1679 C  CG    . PHE A 1 219 ? 8.995   -14.950 7.474   1.000 23.101  ? 219 PHE A CG    1 ? 
ATOM   1680 C  CD1   . PHE A 1 219 ? 10.098  -15.012 8.315   1.000 22.854  ? 219 PHE A CD1   1 ? 
ATOM   1681 C  CD2   . PHE A 1 219 ? 7.781   -15.426 7.941   1.000 24.555  ? 219 PHE A CD2   1 ? 
ATOM   1682 C  CE1   . PHE A 1 219 ? 9.993   -15.559 9.583   1.000 21.945  ? 219 PHE A CE1   1 ? 
ATOM   1683 C  CE2   . PHE A 1 219 ? 7.669   -15.943 9.226   1.000 24.893  ? 219 PHE A CE2   1 ? 
ATOM   1684 C  CZ    . PHE A 1 219 ? 8.777   -16.018 10.039  1.000 24.072  ? 219 PHE A CZ    1 ? 
ATOM   1685 N  N     . GLN A 1 220 ? 9.246   -17.712 5.691   1.000 24.544  ? 220 GLN A N     1 ? 
ATOM   1686 C  CA    . GLN A 1 220 ? 8.451   -18.920 6.046   1.000 28.755  ? 220 GLN A CA    1 ? 
ATOM   1687 C  C     . GLN A 1 220 ? 8.590   -19.199 7.545   1.000 28.434  ? 220 GLN A C     1 ? 
ATOM   1688 O  O     . GLN A 1 220 ? 9.731   -19.182 8.067   1.000 24.889  ? 220 GLN A O     1 ? 
ATOM   1689 C  CB    . GLN A 1 220 ? 8.886   -20.144 5.230   1.000 32.024  ? 220 GLN A CB    1 ? 
ATOM   1690 C  CG    . GLN A 1 220 ? 9.185   -19.851 3.764   1.000 37.699  ? 220 GLN A CG    1 ? 
ATOM   1691 C  CD    . GLN A 1 220 ? 7.963   -19.927 2.884   1.000 48.429  ? 220 GLN A CD    1 ? 
ATOM   1692 O  OE1   . GLN A 1 220 ? 6.900   -20.406 3.301   1.000 55.052  ? 220 GLN A OE1   1 ? 
ATOM   1693 N  NE2   . GLN A 1 220 ? 8.109   -19.455 1.648   1.000 49.537  ? 220 GLN A NE2   1 ? 
ATOM   1694 N  N     . VAL A 1 221 ? 7.463   -19.481 8.189   1.000 27.169  ? 221 VAL A N     1 ? 
ATOM   1695 C  CA    . VAL A 1 221 ? 7.376   -19.861 9.623   1.000 28.748  ? 221 VAL A CA    1 ? 
ATOM   1696 C  C     . VAL A 1 221 ? 8.211   -21.133 9.824   1.000 29.745  ? 221 VAL A C     1 ? 
ATOM   1697 O  O     . VAL A 1 221 ? 8.152   -22.034 8.950   1.000 31.376  ? 221 VAL A O     1 ? 
ATOM   1698 C  CB    . VAL A 1 221 ? 5.912   -20.065 10.057  1.000 26.840  ? 221 VAL A CB    1 ? 
ATOM   1699 C  CG1   . VAL A 1 221 ? 5.789   -20.501 11.498  1.000 29.063  ? 221 VAL A CG1   1 ? 
ATOM   1700 C  CG2   . VAL A 1 221 ? 5.073   -18.831 9.854   1.000 30.205  ? 221 VAL A CG2   1 ? 
ATOM   1701 N  N     . SER A 1 222 ? 8.995   -21.183 10.902  1.000 30.385  ? 222 SER A N     1 ? 
ATOM   1702 C  CA    . SER A 1 222 ? 9.728   -22.388 11.359  1.000 31.893  ? 222 SER A CA    1 ? 
ATOM   1703 C  C     . SER A 1 222 ? 9.211   -22.751 12.746  1.000 32.006  ? 222 SER A C     1 ? 
ATOM   1704 O  O     . SER A 1 222 ? 9.606   -22.078 13.734  1.000 31.136  ? 222 SER A O     1 ? 
ATOM   1705 C  CB    . SER A 1 222 ? 11.242  -22.204 11.323  1.000 34.028  ? 222 SER A CB    1 ? 
ATOM   1706 O  OG    . SER A 1 222 ? 11.922  -23.459 11.431  1.000 31.918  ? 222 SER A OG    1 ? 
ATOM   1707 N  N     . LYS A 1 223 ? 8.323   -23.750 12.793  1.000 34.073  ? 223 LYS A N     1 ? 
ATOM   1708 C  CA    . LYS A 1 223 ? 7.747   -24.323 14.031  1.000 38.555  ? 223 LYS A CA    1 ? 
ATOM   1709 C  C     . LYS A 1 223 ? 7.783   -25.863 13.974  1.000 46.986  ? 223 LYS A C     1 ? 
ATOM   1710 O  O     . LYS A 1 223 ? 7.933   -26.423 12.855  1.000 46.850  ? 223 LYS A O     1 ? 
ATOM   1711 C  CB    . LYS A 1 223 ? 6.325   -23.801 14.222  1.000 38.782  ? 223 LYS A CB    1 ? 
ATOM   1712 C  CG    . LYS A 1 223 ? 5.359   -24.094 13.086  1.000 40.758  ? 223 LYS A CG    1 ? 
ATOM   1713 C  CD    . LYS A 1 223 ? 3.932   -23.688 13.410  1.000 41.425  ? 223 LYS A CD    1 ? 
ATOM   1714 C  CE    . LYS A 1 223 ? 3.035   -23.686 12.189  1.000 39.506  ? 223 LYS A CE    1 ? 
ATOM   1715 N  NZ    . LYS A 1 223 ? 1.690   -23.164 12.520  1.000 39.813  ? 223 LYS A NZ    1 ? 
ATOM   1716 N  N     . ARG A 1 224 ? 7.711   -26.500 15.154  1.000 55.132  ? 224 ARG A N     1 ? 
ATOM   1717 C  CA    . ARG A 1 224 ? 7.423   -27.950 15.378  1.000 61.571  ? 224 ARG A CA    1 ? 
ATOM   1718 C  C     . ARG A 1 224 ? 6.139   -28.070 16.216  1.000 58.807  ? 224 ARG A C     1 ? 
ATOM   1719 O  O     . ARG A 1 224 ? 6.110   -27.530 17.349  1.000 52.293  ? 224 ARG A O     1 ? 
ATOM   1720 C  CB    . ARG A 1 224 ? 8.577   -28.643 16.117  1.000 67.055  ? 224 ARG A CB    1 ? 
ATOM   1721 C  CG    . ARG A 1 224 ? 9.861   -28.814 15.315  1.000 73.988  ? 224 ARG A CG    1 ? 
ATOM   1722 C  CD    . ARG A 1 224 ? 10.960  -29.531 16.111  1.000 81.686  ? 224 ARG A CD    1 ? 
ATOM   1723 N  NE    . ARG A 1 224 ? 11.027  -30.982 15.868  1.000 85.011  ? 224 ARG A NE    1 ? 
ATOM   1724 C  CZ    . ARG A 1 224 ? 11.980  -31.806 16.331  1.000 77.802  ? 224 ARG A CZ    1 ? 
ATOM   1725 N  NH1   . ARG A 1 224 ? 12.966  -31.345 17.084  1.000 73.456  ? 224 ARG A NH1   1 ? 
ATOM   1726 N  NH2   . ARG A 1 224 ? 11.940  -33.094 16.036  1.000 74.759  ? 224 ARG A NH2   1 ? 
ATOM   1727 N  N     . THR A 1 225 ? 5.118   -28.745 15.682  1.000 61.852  ? 225 THR A N     1 ? 
ATOM   1728 C  CA    . THR A 1 225 ? 3.770   -28.880 16.300  1.000 68.902  ? 225 THR A CA    1 ? 
ATOM   1729 C  C     . THR A 1 225 ? 3.644   -30.289 16.886  1.000 71.133  ? 225 THR A C     1 ? 
ATOM   1730 O  O     . THR A 1 225 ? 3.752   -31.246 16.107  1.000 69.574  ? 225 THR A O     1 ? 
ATOM   1731 C  CB    . THR A 1 225 ? 2.671   -28.554 15.275  1.000 69.377  ? 225 THR A CB    1 ? 
ATOM   1732 O  OG1   . THR A 1 225 ? 2.842   -27.189 14.888  1.000 67.321  ? 225 THR A OG1   1 ? 
ATOM   1733 C  CG2   . THR A 1 225 ? 1.265   -28.771 15.798  1.000 69.244  ? 225 THR A CG2   1 ? 
ATOM   1734 N  N     . ASP A 1 226 ? 3.456   -30.401 18.208  1.000 76.493  ? 226 ASP A N     1 ? 
ATOM   1735 C  CA    . ASP A 1 226 ? 3.321   -31.701 18.921  1.000 83.916  ? 226 ASP A CA    1 ? 
ATOM   1736 C  C     . ASP A 1 226 ? 1.919   -32.250 18.664  1.000 90.198  ? 226 ASP A C     1 ? 
ATOM   1737 O  O     . ASP A 1 226 ? 0.953   -31.773 19.259  1.000 87.382  ? 226 ASP A O     1 ? 
ATOM   1738 C  CB    . ASP A 1 226 ? 3.614   -31.567 20.419  1.000 81.847  ? 226 ASP A CB    1 ? 
ATOM   1739 C  CG    . ASP A 1 226 ? 4.044   -32.871 21.075  1.000 83.468  ? 226 ASP A CG    1 ? 
ATOM   1740 O  OD1   . ASP A 1 226 ? 3.455   -33.228 22.118  1.000 79.912  ? 226 ASP A OD1   1 ? 
ATOM   1741 O  OD2   . ASP A 1 226 ? 4.981   -33.514 20.547  1.000 81.903  ? 226 ASP A OD2   1 ? 
ATOM   1742 N  N     . PRO A 1 227 ? 1.766   -33.282 17.791  1.000 96.777  ? 227 PRO A N     1 ? 
ATOM   1743 C  CA    . PRO A 1 227 ? 0.445   -33.748 17.366  1.000 91.571  ? 227 PRO A CA    1 ? 
ATOM   1744 C  C     . PRO A 1 227 ? -0.341  -34.275 18.570  1.000 83.022  ? 227 PRO A C     1 ? 
ATOM   1745 O  O     . PRO A 1 227 ? -1.547  -34.074 18.628  1.000 72.925  ? 227 PRO A O     1 ? 
ATOM   1746 C  CB    . PRO A 1 227 ? 0.710   -34.896 16.374  1.000 92.287  ? 227 PRO A CB    1 ? 
ATOM   1747 C  CG    . PRO A 1 227 ? 2.205   -34.832 16.074  1.000 94.058  ? 227 PRO A CG    1 ? 
ATOM   1748 C  CD    . PRO A 1 227 ? 2.848   -34.117 17.244  1.000 94.128  ? 227 PRO A CD    1 ? 
ATOM   1749 N  N     . VAL A 1 228 ? 0.386   -34.916 19.492  1.000 78.697  ? 228 VAL A N     1 ? 
ATOM   1750 C  CA    . VAL A 1 228 ? -0.141  -35.522 20.749  1.000 82.248  ? 228 VAL A CA    1 ? 
ATOM   1751 C  C     . VAL A 1 228 ? -0.541  -34.395 21.717  1.000 80.947  ? 228 VAL A C     1 ? 
ATOM   1752 O  O     . VAL A 1 228 ? -1.708  -34.392 22.164  1.000 80.273  ? 228 VAL A O     1 ? 
ATOM   1753 C  CB    . VAL A 1 228 ? 0.868   -36.523 21.368  1.000 80.499  ? 228 VAL A CB    1 ? 
ATOM   1754 C  CG1   . VAL A 1 228 ? 1.140   -37.702 20.435  1.000 78.018  ? 228 VAL A CG1   1 ? 
ATOM   1755 C  CG2   . VAL A 1 228 ? 2.183   -35.876 21.794  1.000 71.755  ? 228 VAL A CG2   1 ? 
ATOM   1756 N  N     . SER A 1 229 ? 0.359   -33.446 21.988  1.000 77.944  ? 229 SER A N     1 ? 
ATOM   1757 C  CA    . SER A 1 229 ? 0.166   -32.398 23.024  1.000 83.539  ? 229 SER A CA    1 ? 
ATOM   1758 C  C     . SER A 1 229 ? -0.523  -31.167 22.425  1.000 82.587  ? 229 SER A C     1 ? 
ATOM   1759 O  O     . SER A 1 229 ? -0.995  -30.324 23.217  1.000 77.370  ? 229 SER A O     1 ? 
ATOM   1760 C  CB    . SER A 1 229 ? 1.465   -32.028 23.675  1.000 88.081  ? 229 SER A CB    1 ? 
ATOM   1761 O  OG    . SER A 1 229 ? 1.259   -31.042 24.674  1.000 94.426  ? 229 SER A OG    1 ? 
ATOM   1762 N  N     . GLN A 1 230 ? -0.551  -31.068 21.088  1.000 85.551  ? 230 GLN A N     1 ? 
ATOM   1763 C  CA    . GLN A 1 230 ? -1.113  -29.930 20.303  1.000 87.665  ? 230 GLN A CA    1 ? 
ATOM   1764 C  C     . GLN A 1 230 ? -0.483  -28.610 20.774  1.000 80.019  ? 230 GLN A C     1 ? 
ATOM   1765 O  O     . GLN A 1 230 ? -1.147  -27.562 20.679  1.000 78.810  ? 230 GLN A O     1 ? 
ATOM   1766 C  CB    . GLN A 1 230 ? -2.643  -29.911 20.403  1.000 95.768  ? 230 GLN A CB    1 ? 
ATOM   1767 C  CG    . GLN A 1 230 ? -3.339  -29.339 19.169  1.000 106.037 ? 230 GLN A CG    1 ? 
ATOM   1768 C  CD    . GLN A 1 230 ? -2.677  -29.733 17.866  1.000 112.653 ? 230 GLN A CD    1 ? 
ATOM   1769 O  OE1   . GLN A 1 230 ? -1.730  -29.094 17.407  1.000 117.974 ? 230 GLN A OE1   1 ? 
ATOM   1770 N  NE2   . GLN A 1 230 ? -3.188  -30.786 17.246  1.000 110.993 ? 230 GLN A NE2   1 ? 
ATOM   1771 N  N     . ASN A 1 231 ? 0.762   -28.674 21.246  1.000 71.342  ? 231 ASN A N     1 ? 
ATOM   1772 C  CA    . ASN A 1 231 ? 1.563   -27.520 21.720  1.000 60.410  ? 231 ASN A CA    1 ? 
ATOM   1773 C  C     . ASN A 1 231 ? 2.653   -27.299 20.673  1.000 56.511  ? 231 ASN A C     1 ? 
ATOM   1774 O  O     . ASN A 1 231 ? 3.355   -28.272 20.334  1.000 54.037  ? 231 ASN A O     1 ? 
ATOM   1775 C  CB    . ASN A 1 231 ? 2.068   -27.766 23.150  1.000 60.787  ? 231 ASN A CB    1 ? 
ATOM   1776 C  CG    . ASN A 1 231 ? 3.300   -26.971 23.539  1.000 63.118  ? 231 ASN A CG    1 ? 
ATOM   1777 O  OD1   . ASN A 1 231 ? 3.197   -25.807 23.921  1.000 57.264  ? 231 ASN A OD1   1 ? 
ATOM   1778 N  ND2   . ASN A 1 231 ? 4.458   -27.620 23.532  1.000 57.414  ? 231 ASN A ND2   1 ? 
ATOM   1779 N  N     . VAL A 1 232 ? 2.723   -26.091 20.120  1.000 55.646  ? 232 VAL A N     1 ? 
ATOM   1780 C  CA    . VAL A 1 232 ? 3.631   -25.730 18.994  1.000 52.134  ? 232 VAL A CA    1 ? 
ATOM   1781 C  C     . VAL A 1 232 ? 4.878   -25.076 19.587  1.000 48.997  ? 232 VAL A C     1 ? 
ATOM   1782 O  O     . VAL A 1 232 ? 4.761   -24.494 20.675  1.000 47.907  ? 232 VAL A O     1 ? 
ATOM   1783 C  CB    . VAL A 1 232 ? 2.914   -24.793 18.008  1.000 51.151  ? 232 VAL A CB    1 ? 
ATOM   1784 C  CG1   . VAL A 1 232 ? 3.771   -24.490 16.790  1.000 52.777  ? 232 VAL A CG1   1 ? 
ATOM   1785 C  CG2   . VAL A 1 232 ? 1.564   -25.358 17.601  1.000 50.633  ? 232 VAL A CG2   1 ? 
ATOM   1786 N  N     . THR A 1 233 ? 6.013   -25.161 18.890  1.000 50.611  ? 233 THR A N     1 ? 
ATOM   1787 C  CA    . THR A 1 233 ? 7.317   -24.576 19.314  1.000 48.359  ? 233 THR A CA    1 ? 
ATOM   1788 C  C     . THR A 1 233 ? 8.019   -23.933 18.103  1.000 43.793  ? 233 THR A C     1 ? 
ATOM   1789 O  O     . THR A 1 233 ? 8.245   -24.630 17.092  1.000 41.024  ? 233 THR A O     1 ? 
ATOM   1790 C  CB    . THR A 1 233 ? 8.164   -25.644 20.020  1.000 52.469  ? 233 THR A CB    1 ? 
ATOM   1791 O  OG1   . THR A 1 233 ? 8.188   -26.794 19.170  1.000 52.892  ? 233 THR A OG1   1 ? 
ATOM   1792 C  CG2   . THR A 1 233 ? 7.620   -26.024 21.386  1.000 51.810  ? 233 THR A CG2   1 ? 
ATOM   1793 N  N     . TYR A 1 234 ? 8.381   -22.655 18.220  1.000 41.330  ? 234 TYR A N     1 ? 
ATOM   1794 C  CA    . TYR A 1 234 ? 8.919   -21.825 17.115  1.000 37.242  ? 234 TYR A CA    1 ? 
ATOM   1795 C  C     . TYR A 1 234 ? 10.441  -21.921 17.102  1.000 33.223  ? 234 TYR A C     1 ? 
ATOM   1796 O  O     . TYR A 1 234 ? 11.054  -21.935 18.171  1.000 36.359  ? 234 TYR A O     1 ? 
ATOM   1797 C  CB    . TYR A 1 234 ? 8.389   -20.399 17.238  1.000 37.459  ? 234 TYR A CB    1 ? 
ATOM   1798 C  CG    . TYR A 1 234 ? 6.938   -20.283 16.844  1.000 40.649  ? 234 TYR A CG    1 ? 
ATOM   1799 C  CD1   . TYR A 1 234 ? 5.931   -20.286 17.800  1.000 44.301  ? 234 TYR A CD1   1 ? 
ATOM   1800 C  CD2   . TYR A 1 234 ? 6.562   -20.279 15.509  1.000 42.741  ? 234 TYR A CD2   1 ? 
ATOM   1801 C  CE1   . TYR A 1 234 ? 4.589   -20.238 17.442  1.000 45.985  ? 234 TYR A CE1   1 ? 
ATOM   1802 C  CE2   . TYR A 1 234 ? 5.227   -20.239 15.135  1.000 45.367  ? 234 TYR A CE2   1 ? 
ATOM   1803 C  CZ    . TYR A 1 234 ? 4.236   -20.204 16.102  1.000 45.788  ? 234 TYR A CZ    1 ? 
ATOM   1804 O  OH    . TYR A 1 234 ? 2.925   -20.149 15.732  1.000 44.889  ? 234 TYR A OH    1 ? 
ATOM   1805 N  N     . ASP A 1 235 ? 11.018  -22.054 15.908  1.000 30.754  ? 235 ASP A N     1 ? 
ATOM   1806 C  CA    . ASP A 1 235 ? 12.474  -21.964 15.676  1.000 29.519  ? 235 ASP A CA    1 ? 
ATOM   1807 C  C     . ASP A 1 235 ? 12.753  -20.618 15.012  1.000 27.851  ? 235 ASP A C     1 ? 
ATOM   1808 O  O     . ASP A 1 235 ? 12.659  -20.536 13.774  1.000 30.866  ? 235 ASP A O     1 ? 
ATOM   1809 C  CB    . ASP A 1 235 ? 12.965  -23.145 14.842  1.000 30.934  ? 235 ASP A CB    1 ? 
ATOM   1810 C  CG    . ASP A 1 235 ? 14.463  -23.367 14.875  1.000 33.244  ? 235 ASP A CG    1 ? 
ATOM   1811 O  OD1   . ASP A 1 235 ? 15.205  -22.426 15.228  1.000 37.183  ? 235 ASP A OD1   1 ? 
ATOM   1812 O  OD2   . ASP A 1 235 ? 14.880  -24.469 14.506  1.000 39.615  ? 235 ASP A OD2   1 ? 
ATOM   1813 N  N     . ASP A 1 236 ? 13.072  -19.591 15.799  1.000 25.621  ? 236 ASP A N     1 ? 
ATOM   1814 C  CA    . ASP A 1 236 ? 13.361  -18.233 15.258  1.000 25.701  ? 236 ASP A CA    1 ? 
ATOM   1815 C  C     . ASP A 1 236 ? 14.687  -18.291 14.493  1.000 25.132  ? 236 ASP A C     1 ? 
ATOM   1816 O  O     . ASP A 1 236 ? 14.826  -17.593 13.469  1.000 26.819  ? 236 ASP A O     1 ? 
ATOM   1817 C  CB    . ASP A 1 236 ? 13.371  -17.179 16.368  1.000 23.672  ? 236 ASP A CB    1 ? 
ATOM   1818 C  CG    . ASP A 1 236 ? 11.988  -16.760 16.856  1.000 23.467  ? 236 ASP A CG    1 ? 
ATOM   1819 O  OD1   . ASP A 1 236 ? 11.022  -17.502 16.617  1.000 20.292  ? 236 ASP A OD1   1 ? 
ATOM   1820 O  OD2   . ASP A 1 236 ? 11.892  -15.670 17.471  1.000 23.955  ? 236 ASP A OD2   1 ? 
ATOM   1821 N  N     . ARG A 1 237 ? 15.638  -19.084 14.986  1.000 24.369  ? 237 ARG A N     1 ? 
ATOM   1822 C  CA    . ARG A 1 237 ? 16.975  -19.241 14.375  1.000 22.806  ? 237 ARG A CA    1 ? 
ATOM   1823 C  C     . ARG A 1 237 ? 16.803  -19.786 12.963  1.000 24.000  ? 237 ARG A C     1 ? 
ATOM   1824 O  O     . ARG A 1 237 ? 17.349  -19.188 12.006  1.000 25.035  ? 237 ARG A O     1 ? 
ATOM   1825 C  CB    . ARG A 1 237 ? 17.838  -20.164 15.236  1.000 24.675  ? 237 ARG A CB    1 ? 
ATOM   1826 C  CG    . ARG A 1 237 ? 19.265  -20.340 14.747  1.000 24.765  ? 237 ARG A CG    1 ? 
ATOM   1827 C  CD    . ARG A 1 237 ? 19.741  -21.768 15.035  1.000 27.548  ? 237 ARG A CD    1 ? 
ATOM   1828 N  NE    . ARG A 1 237 ? 18.948  -22.766 14.333  1.000 23.744  ? 237 ARG A NE    1 ? 
ATOM   1829 C  CZ    . ARG A 1 237 ? 19.005  -22.953 13.020  1.000 25.176  ? 237 ARG A CZ    1 ? 
ATOM   1830 N  NH1   . ARG A 1 237 ? 19.814  -22.221 12.268  1.000 26.353  ? 237 ARG A NH1   1 ? 
ATOM   1831 N  NH2   . ARG A 1 237 ? 18.249  -23.869 12.454  1.000 25.887  ? 237 ARG A NH2   1 ? 
ATOM   1832 N  N     . ASP A 1 238 ? 16.057  -20.868 12.833  1.000 23.646  ? 238 ASP A N     1 ? 
ATOM   1833 C  CA    . ASP A 1 238 ? 15.939  -21.610 11.562  1.000 25.288  ? 238 ASP A CA    1 ? 
ATOM   1834 C  C     . ASP A 1 238 ? 15.142  -20.751 10.577  1.000 25.089  ? 238 ASP A C     1 ? 
ATOM   1835 O  O     . ASP A 1 238 ? 15.563  -20.646 9.373   1.000 26.331  ? 238 ASP A O     1 ? 
ATOM   1836 C  CB    . ASP A 1 238 ? 15.267  -22.957 11.791  1.000 26.881  ? 238 ASP A CB    1 ? 
ATOM   1837 C  CG    . ASP A 1 238 ? 14.979  -23.683 10.502  1.000 29.074  ? 238 ASP A CG    1 ? 
ATOM   1838 O  OD1   . ASP A 1 238 ? 15.849  -23.640 9.596   1.000 28.997  ? 238 ASP A OD1   1 ? 
ATOM   1839 O  OD2   . ASP A 1 238 ? 13.887  -24.266 10.405  1.000 30.148  ? 238 ASP A OD2   1 ? 
ATOM   1840 N  N     . ALA A 1 239 ? 14.082  -20.109 11.087  1.000 23.198  ? 239 ALA A N     1 ? 
ATOM   1841 C  CA    . ALA A 1 239 ? 13.194  -19.199 10.331  1.000 21.208  ? 239 ALA A CA    1 ? 
ATOM   1842 C  C     . ALA A 1 239 ? 14.026  -18.103 9.681   1.000 19.333  ? 239 ALA A C     1 ? 
ATOM   1843 O  O     . ALA A 1 239 ? 13.817  -17.876 8.511   1.000 19.049  ? 239 ALA A O     1 ? 
ATOM   1844 C  CB    . ALA A 1 239 ? 12.117  -18.638 11.220  1.000 20.470  ? 239 ALA A CB    1 ? 
ATOM   1845 N  N     . LEU A 1 240 ? 15.001  -17.538 10.393  1.000 19.929  ? 240 LEU A N     1 ? 
ATOM   1846 C  CA    . LEU A 1 240 ? 15.923  -16.495 9.847   1.000 21.216  ? 240 LEU A CA    1 ? 
ATOM   1847 C  C     . LEU A 1 240 ? 16.906  -17.101 8.839   1.000 21.172  ? 240 LEU A C     1 ? 
ATOM   1848 O  O     . LEU A 1 240 ? 17.168  -16.475 7.829   1.000 20.284  ? 240 LEU A O     1 ? 
ATOM   1849 C  CB    . LEU A 1 240 ? 16.681  -15.851 11.001  1.000 20.113  ? 240 LEU A CB    1 ? 
ATOM   1850 C  CG    . LEU A 1 240 ? 15.867  -14.900 11.863  1.000 20.373  ? 240 LEU A CG    1 ? 
ATOM   1851 C  CD1   . LEU A 1 240 ? 16.550  -14.695 13.210  1.000 21.268  ? 240 LEU A CD1   1 ? 
ATOM   1852 C  CD2   . LEU A 1 240 ? 15.656  -13.572 11.139  1.000 19.800  ? 240 LEU A CD2   1 ? 
ATOM   1853 N  N     . GLU A 1 241 ? 17.497  -18.254 9.141   1.000 24.821  ? 241 GLU A N     1 ? 
ATOM   1854 C  CA    . GLU A 1 241 ? 18.452  -18.908 8.219   1.000 25.156  ? 241 GLU A CA    1 ? 
ATOM   1855 C  C     . GLU A 1 241 ? 17.729  -19.139 6.885   1.000 24.915  ? 241 GLU A C     1 ? 
ATOM   1856 O  O     . GLU A 1 241 ? 18.285  -18.732 5.836   1.000 25.791  ? 241 GLU A O     1 ? 
ATOM   1857 C  CB    . GLU A 1 241 ? 19.008  -20.203 8.810   1.000 28.673  ? 241 GLU A CB    1 ? 
ATOM   1858 C  CG    . GLU A 1 241 ? 19.900  -20.970 7.841   1.000 30.262  ? 241 GLU A CG    1 ? 
ATOM   1859 C  CD    . GLU A 1 241 ? 20.030  -22.459 8.130   1.000 32.304  ? 241 GLU A CD    1 ? 
ATOM   1860 O  OE1   . GLU A 1 241 ? 20.215  -22.816 9.319   1.000 31.117  ? 241 GLU A OE1   1 ? 
ATOM   1861 O  OE2   . GLU A 1 241 ? 19.950  -23.259 7.159   1.000 37.206  ? 241 GLU A OE2   1 ? 
ATOM   1862 N  N     . GLN A 1 242 ? 16.537  -19.738 6.909   1.000 25.519  ? 242 GLN A N     1 ? 
ATOM   1863 C  CA    . GLN A 1 242 ? 15.756  -20.033 5.670   1.000 29.403  ? 242 GLN A CA    1 ? 
ATOM   1864 C  C     . GLN A 1 242 ? 15.483  -18.728 4.914   1.000 27.860  ? 242 GLN A C     1 ? 
ATOM   1865 O  O     . GLN A 1 242 ? 15.572  -18.723 3.679   1.000 26.786  ? 242 GLN A O     1 ? 
ATOM   1866 C  CB    . GLN A 1 242 ? 14.415  -20.698 5.962   1.000 33.289  ? 242 GLN A CB    1 ? 
ATOM   1867 C  CG    . GLN A 1 242 ? 14.496  -22.118 6.494   1.000 37.641  ? 242 GLN A CG    1 ? 
ATOM   1868 C  CD    . GLN A 1 242 ? 13.115  -22.615 6.851   1.000 43.230  ? 242 GLN A CD    1 ? 
ATOM   1869 O  OE1   . GLN A 1 242 ? 12.159  -22.430 6.098   1.000 49.782  ? 242 GLN A OE1   1 ? 
ATOM   1870 N  NE2   . GLN A 1 242 ? 12.985  -23.222 8.022   1.000 48.999  ? 242 GLN A NE2   1 ? 
ATOM   1871 N  N     . PHE A 1 243 ? 15.121  -17.664 5.629   1.000 28.370  ? 243 PHE A N     1 ? 
ATOM   1872 C  CA    . PHE A 1 243 ? 14.678  -16.394 5.012   1.000 24.361  ? 243 PHE A CA    1 ? 
ATOM   1873 C  C     . PHE A 1 243 ? 15.906  -15.757 4.390   1.000 24.737  ? 243 PHE A C     1 ? 
ATOM   1874 O  O     . PHE A 1 243 ? 15.874  -15.402 3.183   1.000 21.905  ? 243 PHE A O     1 ? 
ATOM   1875 C  CB    . PHE A 1 243 ? 13.951  -15.503 6.022   1.000 23.670  ? 243 PHE A CB    1 ? 
ATOM   1876 C  CG    . PHE A 1 243 ? 13.751  -14.068 5.589   1.000 23.017  ? 243 PHE A CG    1 ? 
ATOM   1877 C  CD1   . PHE A 1 243 ? 13.296  -13.763 4.318   1.000 23.097  ? 243 PHE A CD1   1 ? 
ATOM   1878 C  CD2   . PHE A 1 243 ? 13.942  -13.020 6.477   1.000 24.702  ? 243 PHE A CD2   1 ? 
ATOM   1879 C  CE1   . PHE A 1 243 ? 13.080  -12.447 3.934   1.000 22.382  ? 243 PHE A CE1   1 ? 
ATOM   1880 C  CE2   . PHE A 1 243 ? 13.755  -11.703 6.074   1.000 24.188  ? 243 PHE A CE2   1 ? 
ATOM   1881 C  CZ    . PHE A 1 243 ? 13.305  -11.425 4.812   1.000 22.918  ? 243 PHE A CZ    1 ? 
ATOM   1882 N  N     . VAL A 1 244 ? 16.998  -15.714 5.152   1.000 24.321  ? 244 VAL A N     1 ? 
ATOM   1883 C  CA    . VAL A 1 244 ? 18.266  -15.047 4.725   1.000 23.780  ? 244 VAL A CA    1 ? 
ATOM   1884 C  C     . VAL A 1 244 ? 18.868  -15.806 3.531   1.000 22.549  ? 244 VAL A C     1 ? 
ATOM   1885 O  O     . VAL A 1 244 ? 19.467  -15.142 2.653   1.000 20.220  ? 244 VAL A O     1 ? 
ATOM   1886 C  CB    . VAL A 1 244 ? 19.264  -14.929 5.892   1.000 23.195  ? 244 VAL A CB    1 ? 
ATOM   1887 C  CG1   . VAL A 1 244 ? 20.632  -14.504 5.412   1.000 23.145  ? 244 VAL A CG1   1 ? 
ATOM   1888 C  CG2   . VAL A 1 244 ? 18.767  -13.975 6.970   1.000 22.786  ? 244 VAL A CG2   1 ? 
ATOM   1889 N  N     . GLN A 1 245 ? 18.754  -17.128 3.524   1.000 21.584  ? 245 GLN A N     1 ? 
ATOM   1890 C  CA    . GLN A 1 245 ? 19.239  -17.983 2.415   1.000 25.984  ? 245 GLN A CA    1 ? 
ATOM   1891 C  C     . GLN A 1 245 ? 18.440  -17.604 1.156   1.000 27.285  ? 245 GLN A C     1 ? 
ATOM   1892 O  O     . GLN A 1 245 ? 19.059  -17.299 0.106   1.000 22.777  ? 245 GLN A O     1 ? 
ATOM   1893 C  CB    . GLN A 1 245 ? 19.083  -19.469 2.778   1.000 26.212  ? 245 GLN A CB    1 ? 
ATOM   1894 C  CG    . GLN A 1 245 ? 19.567  -20.438 1.697   1.000 26.858  ? 245 GLN A CG    1 ? 
ATOM   1895 C  CD    . GLN A 1 245 ? 21.035  -20.279 1.386   1.000 27.007  ? 245 GLN A CD    1 ? 
ATOM   1896 O  OE1   . GLN A 1 245 ? 21.899  -20.719 2.139   1.000 30.618  ? 245 GLN A OE1   1 ? 
ATOM   1897 N  NE2   . GLN A 1 245 ? 21.328  -19.687 0.243   1.000 29.000  ? 245 GLN A NE2   1 ? 
ATOM   1898 N  N     . THR A 1 246 ? 17.111  -17.553 1.279   1.000 29.185  ? 246 THR A N     1 ? 
ATOM   1899 C  CA    . THR A 1 246 ? 16.197  -17.230 0.159   1.000 27.001  ? 246 THR A CA    1 ? 
ATOM   1900 C  C     . THR A 1 246 ? 16.604  -15.876 -0.400  1.000 29.511  ? 246 THR A C     1 ? 
ATOM   1901 O  O     . THR A 1 246 ? 16.762  -15.770 -1.632  1.000 33.939  ? 246 THR A O     1 ? 
ATOM   1902 C  CB    . THR A 1 246 ? 14.742  -17.317 0.603   1.000 28.229  ? 246 THR A CB    1 ? 
ATOM   1903 O  OG1   . THR A 1 246 ? 14.586  -18.629 1.144   1.000 29.669  ? 246 THR A OG1   1 ? 
ATOM   1904 C  CG2   . THR A 1 246 ? 13.757  -17.098 -0.526  1.000 28.908  ? 246 THR A CG2   1 ? 
ATOM   1905 N  N     . MET A 1 247 ? 16.849  -14.899 0.465   1.000 27.058  ? 247 MET A N     1 ? 
ATOM   1906 C  CA    . MET A 1 247 ? 17.289  -13.555 0.023   1.000 28.332  ? 247 MET A CA    1 ? 
ATOM   1907 C  C     . MET A 1 247 ? 18.617  -13.667 -0.735  1.000 28.363  ? 247 MET A C     1 ? 
ATOM   1908 O  O     . MET A 1 247 ? 18.697  -13.109 -1.854  1.000 29.316  ? 247 MET A O     1 ? 
ATOM   1909 C  CB    . MET A 1 247 ? 17.460  -12.580 1.190   1.000 26.329  ? 247 MET A CB    1 ? 
ATOM   1910 C  CG    . MET A 1 247 ? 16.150  -12.046 1.748   1.000 27.844  ? 247 MET A CG    1 ? 
ATOM   1911 S  SD    . MET A 1 247 ? 16.422  -10.510 2.668   1.000 25.137  ? 247 MET A SD    1 ? 
ATOM   1912 C  CE    . MET A 1 247 ? 16.971  -11.212 4.220   1.000 27.110  ? 247 MET A CE    1 ? 
ATOM   1913 N  N     . LEU A 1 248 ? 19.638  -14.283 -0.141  1.000 26.792  ? 248 LEU A N     1 ? 
ATOM   1914 C  CA    . LEU A 1 248 ? 20.966  -14.413 -0.800  1.000 29.940  ? 248 LEU A CA    1 ? 
ATOM   1915 C  C     . LEU A 1 248 ? 20.756  -15.079 -2.171  1.000 29.022  ? 248 LEU A C     1 ? 
ATOM   1916 O  O     . LEU A 1 248 ? 21.226  -14.519 -3.177  1.000 34.317  ? 248 LEU A O     1 ? 
ATOM   1917 C  CB    . LEU A 1 248 ? 21.930  -15.222 0.080   1.000 29.944  ? 248 LEU A CB    1 ? 
ATOM   1918 C  CG    . LEU A 1 248 ? 22.862  -14.394 0.964   1.000 31.346  ? 248 LEU A CG    1 ? 
ATOM   1919 C  CD1   . LEU A 1 248 ? 23.253  -15.159 2.214   1.000 31.130  ? 248 LEU A CD1   1 ? 
ATOM   1920 C  CD2   . LEU A 1 248 ? 24.099  -13.964 0.206   1.000 33.378  ? 248 LEU A CD2   1 ? 
ATOM   1921 N  N     . ASP A 1 249 ? 20.057  -16.216 -2.178  1.000 26.912  ? 249 ASP A N     1 ? 
ATOM   1922 C  CA    . ASP A 1 249 ? 19.719  -17.025 -3.371  1.000 28.527  ? 249 ASP A CA    1 ? 
ATOM   1923 C  C     . ASP A 1 249 ? 19.191  -16.101 -4.466  1.000 29.012  ? 249 ASP A C     1 ? 
ATOM   1924 O  O     . ASP A 1 249 ? 19.611  -16.269 -5.626  1.000 31.785  ? 249 ASP A O     1 ? 
ATOM   1925 C  CB    . ASP A 1 249 ? 18.734  -18.152 -3.013  1.000 28.136  ? 249 ASP A CB    1 ? 
ATOM   1926 C  CG    . ASP A 1 249 ? 19.386  -19.355 -2.333  1.000 29.945  ? 249 ASP A CG    1 ? 
ATOM   1927 O  OD1   . ASP A 1 249 ? 20.646  -19.337 -2.185  1.000 29.946  ? 249 ASP A OD1   1 ? 
ATOM   1928 O  OD2   . ASP A 1 249 ? 18.643  -20.293 -1.923  1.000 27.576  ? 249 ASP A OD2   1 ? 
ATOM   1929 N  N     . ASN A 1 250 ? 18.355  -15.121 -4.113  1.000 28.602  ? 250 ASN A N     1 ? 
ATOM   1930 C  CA    . ASN A 1 250 ? 17.622  -14.276 -5.098  1.000 27.375  ? 250 ASN A CA    1 ? 
ATOM   1931 C  C     . ASN A 1 250 ? 18.504  -13.145 -5.637  1.000 27.907  ? 250 ASN A C     1 ? 
ATOM   1932 O  O     . ASN A 1 250 ? 18.011  -12.393 -6.495  1.000 28.374  ? 250 ASN A O     1 ? 
ATOM   1933 C  CB    . ASN A 1 250 ? 16.344  -13.695 -4.507  1.000 28.036  ? 250 ASN A CB    1 ? 
ATOM   1934 C  CG    . ASN A 1 250 ? 15.160  -14.611 -4.677  1.000 27.615  ? 250 ASN A CG    1 ? 
ATOM   1935 O  OD1   . ASN A 1 250 ? 14.281  -14.335 -5.492  1.000 33.591  ? 250 ASN A OD1   1 ? 
ATOM   1936 N  ND2   . ASN A 1 250 ? 15.111  -15.673 -3.906  1.000 21.368  ? 250 ASN A ND2   1 ? 
ATOM   1937 N  N     . PHE A 1 251 ? 19.754  -13.029 -5.186  1.000 25.929  ? 251 PHE A N     1 ? 
ATOM   1938 C  CA    . PHE A 1 251 ? 20.743  -12.094 -5.778  1.000 27.313  ? 251 PHE A CA    1 ? 
ATOM   1939 C  C     . PHE A 1 251 ? 21.080  -12.603 -7.196  1.000 27.854  ? 251 PHE A C     1 ? 
ATOM   1940 O  O     . PHE A 1 251 ? 21.092  -13.810 -7.413  1.000 31.601  ? 251 PHE A O     1 ? 
ATOM   1941 C  CB    . PHE A 1 251 ? 21.987  -11.949 -4.889  1.000 24.953  ? 251 PHE A CB    1 ? 
ATOM   1942 C  CG    . PHE A 1 251 ? 21.939  -10.873 -3.821  1.000 23.480  ? 251 PHE A CG    1 ? 
ATOM   1943 C  CD1   . PHE A 1 251 ? 21.367  -11.127 -2.582  1.000 22.878  ? 251 PHE A CD1   1 ? 
ATOM   1944 C  CD2   . PHE A 1 251 ? 22.557  -9.637  -4.016  1.000 23.439  ? 251 PHE A CD2   1 ? 
ATOM   1945 C  CE1   . PHE A 1 251 ? 21.365  -10.155 -1.589  1.000 22.303  ? 251 PHE A CE1   1 ? 
ATOM   1946 C  CE2   . PHE A 1 251 ? 22.557  -8.671  -3.021  1.000 23.421  ? 251 PHE A CE2   1 ? 
ATOM   1947 C  CZ    . PHE A 1 251 ? 21.954  -8.929  -1.812  1.000 21.164  ? 251 PHE A CZ    1 ? 
ATOM   1948 N  N     . HIS A 1 252 ? 21.319  -11.691 -8.130  1.000 27.724  ? 252 HIS A N     1 ? 
ATOM   1949 C  CA    . HIS A 1 252 ? 21.689  -11.978 -9.535  1.000 31.722  ? 252 HIS A CA    1 ? 
ATOM   1950 C  C     . HIS A 1 252 ? 22.839  -11.037 -9.896  1.000 29.755  ? 252 HIS A C     1 ? 
ATOM   1951 O  O     . HIS A 1 252 ? 22.755  -9.854  -9.543  1.000 28.976  ? 252 HIS A O     1 ? 
ATOM   1952 C  CB    . HIS A 1 252 ? 20.434  -11.849 -10.423 1.000 37.917  ? 252 HIS A CB    1 ? 
ATOM   1953 C  CG    . HIS A 1 252 ? 20.645  -12.048 -11.897 1.000 43.436  ? 252 HIS A CG    1 ? 
ATOM   1954 N  ND1   . HIS A 1 252 ? 20.288  -13.224 -12.550 1.000 43.571  ? 252 HIS A ND1   1 ? 
ATOM   1955 C  CD2   . HIS A 1 252 ? 21.081  -11.198 -12.859 1.000 42.542  ? 252 HIS A CD2   1 ? 
ATOM   1956 C  CE1   . HIS A 1 252 ? 20.529  -13.093 -13.839 1.000 46.094  ? 252 HIS A CE1   1 ? 
ATOM   1957 N  NE2   . HIS A 1 252 ? 21.019  -11.855 -14.053 1.000 41.447  ? 252 HIS A NE2   1 ? 
ATOM   1958 N  N     . ASP A 1 253 ? 23.900  -11.552 -10.519 1.000 31.675  ? 253 ASP A N     1 ? 
ATOM   1959 C  CA    . ASP A 1 253 ? 25.068  -10.725 -10.911 1.000 28.949  ? 253 ASP A CA    1 ? 
ATOM   1960 C  C     . ASP A 1 253 ? 24.598  -9.733  -11.959 1.000 27.340  ? 253 ASP A C     1 ? 
ATOM   1961 O  O     . ASP A 1 253 ? 23.821  -10.126 -12.781 1.000 29.692  ? 253 ASP A O     1 ? 
ATOM   1962 C  CB    . ASP A 1 253 ? 26.227  -11.601 -11.349 1.000 30.354  ? 253 ASP A CB    1 ? 
ATOM   1963 C  CG    . ASP A 1 253 ? 26.741  -12.389 -10.162 1.000 32.608  ? 253 ASP A CG    1 ? 
ATOM   1964 O  OD1   . ASP A 1 253 ? 26.930  -11.753 -9.108  1.000 30.066  ? 253 ASP A OD1   1 ? 
ATOM   1965 O  OD2   . ASP A 1 253 ? 26.826  -13.643 -10.266 1.000 32.950  ? 253 ASP A OD2   1 ? 
ATOM   1966 N  N     . THR A 1 254 ? 25.028  -8.476  -11.864 1.000 25.531  ? 254 THR A N     1 ? 
ATOM   1967 C  CA    . THR A 1 254 ? 24.449  -7.353  -12.621 1.000 25.282  ? 254 THR A CA    1 ? 
ATOM   1968 C  C     . THR A 1 254 ? 25.575  -6.443  -13.109 1.000 27.793  ? 254 THR A C     1 ? 
ATOM   1969 O  O     . THR A 1 254 ? 26.149  -5.676  -12.289 1.000 25.974  ? 254 THR A O     1 ? 
ATOM   1970 C  CB    . THR A 1 254 ? 23.386  -6.632  -11.798 1.000 27.194  ? 254 THR A CB    1 ? 
ATOM   1971 O  OG1   . THR A 1 254 ? 22.302  -7.545  -11.623 1.000 30.748  ? 254 THR A OG1   1 ? 
ATOM   1972 C  CG2   . THR A 1 254 ? 22.882  -5.361  -12.436 1.000 27.728  ? 254 THR A CG2   1 ? 
ATOM   1973 N  N     . TRP A 1 255 ? 25.848  -6.513  -14.411 1.000 24.247  ? 255 TRP A N     1 ? 
ATOM   1974 C  CA    . TRP A 1 255 ? 26.886  -5.712  -15.077 1.000 27.701  ? 255 TRP A CA    1 ? 
ATOM   1975 C  C     . TRP A 1 255 ? 26.577  -4.238  -14.854 1.000 28.937  ? 255 TRP A C     1 ? 
ATOM   1976 O  O     . TRP A 1 255 ? 25.426  -3.867  -15.075 1.000 27.966  ? 255 TRP A O     1 ? 
ATOM   1977 C  CB    . TRP A 1 255 ? 26.942  -6.052  -16.573 1.000 29.044  ? 255 TRP A CB    1 ? 
ATOM   1978 C  CG    . TRP A 1 255 ? 28.108  -5.415  -17.252 1.000 27.782  ? 255 TRP A CG    1 ? 
ATOM   1979 C  CD1   . TRP A 1 255 ? 28.124  -4.257  -17.972 1.000 27.168  ? 255 TRP A CD1   1 ? 
ATOM   1980 C  CD2   . TRP A 1 255 ? 29.470  -5.841  -17.135 1.000 28.925  ? 255 TRP A CD2   1 ? 
ATOM   1981 N  NE1   . TRP A 1 255 ? 29.405  -3.959  -18.352 1.000 28.597  ? 255 TRP A NE1   1 ? 
ATOM   1982 C  CE2   . TRP A 1 255 ? 30.252  -4.912  -17.851 1.000 30.087  ? 255 TRP A CE2   1 ? 
ATOM   1983 C  CE3   . TRP A 1 255 ? 30.099  -6.913  -16.495 1.000 30.760  ? 255 TRP A CE3   1 ? 
ATOM   1984 C  CZ2   . TRP A 1 255 ? 31.631  -5.054  -17.978 1.000 31.430  ? 255 TRP A CZ2   1 ? 
ATOM   1985 C  CZ3   . TRP A 1 255 ? 31.465  -7.052  -16.615 1.000 32.320  ? 255 TRP A CZ3   1 ? 
ATOM   1986 C  CH2   . TRP A 1 255 ? 32.218  -6.135  -17.348 1.000 31.113  ? 255 TRP A CH2   1 ? 
ATOM   1987 N  N     . ASP A 1 256 ? 27.576  -3.458  -14.425 1.000 31.745  ? 256 ASP A N     1 ? 
ATOM   1988 C  CA    . ASP A 1 256 ? 27.615  -1.976  -14.526 1.000 36.387  ? 256 ASP A CA    1 ? 
ATOM   1989 C  C     . ASP A 1 256 ? 28.632  -1.616  -15.621 1.000 40.645  ? 256 ASP A C     1 ? 
ATOM   1990 O  O     . ASP A 1 256 ? 29.821  -1.990  -15.474 1.000 41.957  ? 256 ASP A O     1 ? 
ATOM   1991 C  CB    . ASP A 1 256 ? 27.982  -1.323  -13.184 1.000 39.255  ? 256 ASP A CB    1 ? 
ATOM   1992 C  CG    . ASP A 1 256 ? 27.868  0.196   -13.189 1.000 40.242  ? 256 ASP A CG    1 ? 
ATOM   1993 O  OD1   . ASP A 1 256 ? 28.649  0.852   -13.900 1.000 46.889  ? 256 ASP A OD1   1 ? 
ATOM   1994 O  OD2   . ASP A 1 256 ? 26.991  0.714   -12.493 1.000 44.206  ? 256 ASP A OD2   1 ? 
ATOM   1995 N  N     . SER A 1 257 ? 28.175  -0.950  -16.688 1.000 40.700  ? 257 SER A N     1 ? 
ATOM   1996 C  CA    . SER A 1 257 ? 28.980  -0.611  -17.891 1.000 41.312  ? 257 SER A CA    1 ? 
ATOM   1997 C  C     . SER A 1 257 ? 29.843  0.616   -17.591 1.000 39.935  ? 257 SER A C     1 ? 
ATOM   1998 O  O     . SER A 1 257 ? 31.011  0.633   -18.012 1.000 36.015  ? 257 SER A O     1 ? 
ATOM   1999 C  CB    . SER A 1 257 ? 28.098  -0.405  -19.110 1.000 43.566  ? 257 SER A CB    1 ? 
ATOM   2000 O  OG    . SER A 1 257 ? 27.534  -1.643  -19.542 1.000 41.584  ? 257 SER A OG    1 ? 
ATOM   2001 N  N     . LYS A 1 258 ? 29.298  1.578   -16.847 1.000 43.893  ? 258 LYS A N     1 ? 
ATOM   2002 C  CA    . LYS A 1 258 ? 30.076  2.707   -16.279 1.000 46.971  ? 258 LYS A CA    1 ? 
ATOM   2003 C  C     . LYS A 1 258 ? 31.324  2.125   -15.612 1.000 45.748  ? 258 LYS A C     1 ? 
ATOM   2004 O  O     . LYS A 1 258 ? 32.435  2.500   -15.994 1.000 46.164  ? 258 LYS A O     1 ? 
ATOM   2005 C  CB    . LYS A 1 258 ? 29.244  3.511   -15.274 1.000 49.709  ? 258 LYS A CB    1 ? 
ATOM   2006 C  CG    . LYS A 1 258 ? 29.451  5.019   -15.341 1.000 56.367  ? 258 LYS A CG    1 ? 
ATOM   2007 C  CD    . LYS A 1 258 ? 28.855  5.660   -16.585 1.000 59.736  ? 258 LYS A CD    1 ? 
ATOM   2008 C  CE    . LYS A 1 258 ? 28.896  7.177   -16.554 1.000 62.398  ? 258 LYS A CE    1 ? 
ATOM   2009 N  NZ    . LYS A 1 258 ? 28.667  7.763   -17.897 1.000 58.914  ? 258 LYS A NZ    1 ? 
ATOM   2010 N  N     . ASP A 1 259 ? 31.138  1.202   -14.677 1.000 44.551  ? 259 ASP A N     1 ? 
ATOM   2011 C  CA    . ASP A 1 259 ? 32.226  0.764   -13.768 1.000 49.794  ? 259 ASP A CA    1 ? 
ATOM   2012 C  C     . ASP A 1 259 ? 32.987  -0.364  -14.461 1.000 46.432  ? 259 ASP A C     1 ? 
ATOM   2013 O  O     . ASP A 1 259 ? 33.982  -0.819  -13.897 1.000 47.263  ? 259 ASP A O     1 ? 
ATOM   2014 C  CB    . ASP A 1 259 ? 31.688  0.379   -12.374 1.000 50.955  ? 259 ASP A CB    1 ? 
ATOM   2015 C  CG    . ASP A 1 259 ? 31.219  1.546   -11.494 1.000 50.818  ? 259 ASP A CG    1 ? 
ATOM   2016 O  OD1   . ASP A 1 259 ? 31.451  2.729   -11.873 1.000 52.124  ? 259 ASP A OD1   1 ? 
ATOM   2017 O  OD2   . ASP A 1 259 ? 30.612  1.271   -10.429 1.000 48.027  ? 259 ASP A OD2   1 ? 
ATOM   2018 N  N     . GLN A 1 260 ? 32.531  -0.781  -15.650 1.000 47.374  ? 260 GLN A N     1 ? 
ATOM   2019 C  CA    . GLN A 1 260 ? 33.021  -1.998  -16.362 1.000 43.892  ? 260 GLN A CA    1 ? 
ATOM   2020 C  C     . GLN A 1 260 ? 33.264  -3.121  -15.334 1.000 38.337  ? 260 GLN A C     1 ? 
ATOM   2021 O  O     . GLN A 1 260 ? 34.295  -3.804  -15.415 1.000 34.788  ? 260 GLN A O     1 ? 
ATOM   2022 C  CB    . GLN A 1 260 ? 34.283  -1.681  -17.182 1.000 43.243  ? 260 GLN A CB    1 ? 
ATOM   2023 C  CG    . GLN A 1 260 ? 33.990  -1.090  -18.560 1.000 40.719  ? 260 GLN A CG    1 ? 
ATOM   2024 C  CD    . GLN A 1 260 ? 33.296  -2.093  -19.452 1.000 37.257  ? 260 GLN A CD    1 ? 
ATOM   2025 O  OE1   . GLN A 1 260 ? 33.803  -3.183  -19.709 1.000 30.732  ? 260 GLN A OE1   1 ? 
ATOM   2026 N  NE2   . GLN A 1 260 ? 32.085  -1.760  -19.865 1.000 34.923  ? 260 GLN A NE2   1 ? 
ATOM   2027 N  N     . ARG A 1 261 ? 32.316  -3.342  -14.432 1.000 36.068  ? 261 ARG A N     1 ? 
ATOM   2028 C  CA    . ARG A 1 261 ? 32.392  -4.457  -13.459 1.000 37.505  ? 261 ARG A CA    1 ? 
ATOM   2029 C  C     . ARG A 1 261 ? 30.974  -4.977  -13.176 1.000 34.236  ? 261 ARG A C     1 ? 
ATOM   2030 O  O     . ARG A 1 261 ? 29.984  -4.192  -13.316 1.000 33.816  ? 261 ARG A O     1 ? 
ATOM   2031 C  CB    . ARG A 1 261 ? 33.189  -3.987  -12.230 1.000 42.264  ? 261 ARG A CB    1 ? 
ATOM   2032 C  CG    . ARG A 1 261 ? 32.966  -4.793  -10.958 1.000 45.360  ? 261 ARG A CG    1 ? 
ATOM   2033 C  CD    . ARG A 1 261 ? 34.180  -4.913  -10.050 1.000 47.246  ? 261 ARG A CD    1 ? 
ATOM   2034 N  NE    . ARG A 1 261 ? 33.780  -5.420  -8.732  1.000 52.723  ? 261 ARG A NE    1 ? 
ATOM   2035 C  CZ    . ARG A 1 261 ? 34.572  -6.072  -7.861  1.000 54.776  ? 261 ARG A CZ    1 ? 
ATOM   2036 N  NH1   . ARG A 1 261 ? 35.835  -6.326  -8.164  1.000 51.534  ? 261 ARG A NH1   1 ? 
ATOM   2037 N  NH2   . ARG A 1 261 ? 34.090  -6.463  -6.683  1.000 53.202  ? 261 ARG A NH2   1 ? 
ATOM   2038 N  N     . SER A 1 262 ? 30.889  -6.258  -12.814 1.000 28.165  ? 262 SER A N     1 ? 
ATOM   2039 C  CA    . SER A 1 262 ? 29.681  -6.939  -12.287 1.000 28.809  ? 262 SER A CA    1 ? 
ATOM   2040 C  C     . SER A 1 262 ? 29.519  -6.685  -10.768 1.000 28.864  ? 262 SER A C     1 ? 
ATOM   2041 O  O     . SER A 1 262 ? 30.483  -6.896  -10.009 1.000 25.068  ? 262 SER A O     1 ? 
ATOM   2042 C  CB    . SER A 1 262 ? 29.777  -8.406  -12.589 1.000 27.535  ? 262 SER A CB    1 ? 
ATOM   2043 O  OG    . SER A 1 262 ? 28.557  -9.046  -12.308 1.000 33.733  ? 262 SER A OG    1 ? 
ATOM   2044 N  N     . TYR A 1 263 ? 28.319  -6.308  -10.333 1.000 27.037  ? 263 TYR A N     1 ? 
ATOM   2045 C  CA    . TYR A 1 263 ? 27.930  -6.205  -8.902  1.000 27.885  ? 263 TYR A CA    1 ? 
ATOM   2046 C  C     . TYR A 1 263 ? 26.756  -7.137  -8.665  1.000 27.700  ? 263 TYR A C     1 ? 
ATOM   2047 O  O     . TYR A 1 263 ? 25.820  -7.112  -9.458  1.000 30.308  ? 263 TYR A O     1 ? 
ATOM   2048 C  CB    . TYR A 1 263 ? 27.533  -4.769  -8.558  1.000 24.936  ? 263 TYR A CB    1 ? 
ATOM   2049 C  CG    . TYR A 1 263 ? 28.608  -3.738  -8.779  1.000 26.846  ? 263 TYR A CG    1 ? 
ATOM   2050 C  CD1   . TYR A 1 263 ? 29.771  -3.736  -8.024  1.000 26.910  ? 263 TYR A CD1   1 ? 
ATOM   2051 C  CD2   . TYR A 1 263 ? 28.451  -2.737  -9.722  1.000 28.601  ? 263 TYR A CD2   1 ? 
ATOM   2052 C  CE1   . TYR A 1 263 ? 30.749  -2.773  -8.205  1.000 27.023  ? 263 TYR A CE1   1 ? 
ATOM   2053 C  CE2   . TYR A 1 263 ? 29.424  -1.769  -9.918  1.000 27.633  ? 263 TYR A CE2   1 ? 
ATOM   2054 C  CZ    . TYR A 1 263 ? 30.574  -1.782  -9.155  1.000 26.259  ? 263 TYR A CZ    1 ? 
ATOM   2055 O  OH    . TYR A 1 263 ? 31.516  -0.810  -9.341  1.000 25.818  ? 263 TYR A OH    1 ? 
ATOM   2056 N  N     . PRO A 1 264 ? 26.728  -7.948  -7.574  1.000 29.404  ? 264 PRO A N     1 ? 
ATOM   2057 C  CA    . PRO A 1 264 ? 25.533  -8.714  -7.232  1.000 29.502  ? 264 PRO A CA    1 ? 
ATOM   2058 C  C     . PRO A 1 264 ? 24.451  -7.700  -6.815  1.000 26.152  ? 264 PRO A C     1 ? 
ATOM   2059 O  O     . PRO A 1 264 ? 24.806  -6.602  -6.488  1.000 28.091  ? 264 PRO A O     1 ? 
ATOM   2060 C  CB    . PRO A 1 264 ? 25.960  -9.653  -6.073  1.000 29.643  ? 264 PRO A CB    1 ? 
ATOM   2061 C  CG    . PRO A 1 264 ? 27.462  -9.461  -5.927  1.000 28.322  ? 264 PRO A CG    1 ? 
ATOM   2062 C  CD    . PRO A 1 264 ? 27.788  -8.125  -6.564  1.000 30.717  ? 264 PRO A CD    1 ? 
ATOM   2063 N  N     . ARG A 1 265 ? 23.178  -8.061  -6.916  1.000 24.647  ? 265 ARG A N     1 ? 
ATOM   2064 C  CA    . ARG A 1 265 ? 22.047  -7.117  -6.728  1.000 24.996  ? 265 ARG A CA    1 ? 
ATOM   2065 C  C     . ARG A 1 265 ? 20.810  -7.936  -6.366  1.000 24.746  ? 265 ARG A C     1 ? 
ATOM   2066 O  O     . ARG A 1 265 ? 20.613  -8.971  -6.964  1.000 26.113  ? 265 ARG A O     1 ? 
ATOM   2067 C  CB    . ARG A 1 265 ? 21.808  -6.280  -7.991  1.000 27.981  ? 265 ARG A CB    1 ? 
ATOM   2068 C  CG    . ARG A 1 265 ? 22.847  -5.192  -8.241  1.000 29.737  ? 265 ARG A CG    1 ? 
ATOM   2069 C  CD    . ARG A 1 265 ? 22.304  -4.048  -9.071  1.000 30.969  ? 265 ARG A CD    1 ? 
ATOM   2070 N  NE    . ARG A 1 265 ? 21.180  -3.391  -8.404  1.000 32.262  ? 265 ARG A NE    1 ? 
ATOM   2071 C  CZ    . ARG A 1 265 ? 21.284  -2.357  -7.563  1.000 30.134  ? 265 ARG A CZ    1 ? 
ATOM   2072 N  NH1   . ARG A 1 265 ? 22.470  -1.849  -7.268  1.000 29.865  ? 265 ARG A NH1   1 ? 
ATOM   2073 N  NH2   . ARG A 1 265 ? 20.198  -1.848  -7.001  1.000 29.375  ? 265 ARG A NH2   1 ? 
ATOM   2074 N  N     . LEU A 1 266 ? 20.066  -7.517  -5.347  1.000 26.197  ? 266 LEU A N     1 ? 
ATOM   2075 C  CA    . LEU A 1 266 ? 18.788  -8.143  -4.944  1.000 22.424  ? 266 LEU A CA    1 ? 
ATOM   2076 C  C     . LEU A 1 266 ? 17.663  -7.197  -5.325  1.000 22.099  ? 266 LEU A C     1 ? 
ATOM   2077 O  O     . LEU A 1 266 ? 17.779  -5.963  -5.030  1.000 25.108  ? 266 LEU A O     1 ? 
ATOM   2078 C  CB    . LEU A 1 266 ? 18.798  -8.408  -3.447  1.000 23.410  ? 266 LEU A CB    1 ? 
ATOM   2079 C  CG    . LEU A 1 266 ? 17.536  -9.078  -2.943  1.000 23.484  ? 266 LEU A CG    1 ? 
ATOM   2080 C  CD1   . LEU A 1 266 ? 17.423  -10.468 -3.507  1.000 23.903  ? 266 LEU A CD1   1 ? 
ATOM   2081 C  CD2   . LEU A 1 266 ? 17.525  -9.111  -1.437  1.000 25.340  ? 266 LEU A CD2   1 ? 
ATOM   2082 N  N     . THR A 1 267 ? 16.671  -7.706  -6.050  1.000 19.558  ? 267 THR A N     1 ? 
ATOM   2083 C  CA    . THR A 1 267 ? 15.484  -6.932  -6.477  1.000 20.010  ? 267 THR A CA    1 ? 
ATOM   2084 C  C     . THR A 1 267 ? 14.292  -7.337  -5.610  1.000 19.569  ? 267 THR A C     1 ? 
ATOM   2085 O  O     . THR A 1 267 ? 13.988  -8.514  -5.563  1.000 18.263  ? 267 THR A O     1 ? 
ATOM   2086 C  CB    . THR A 1 267 ? 15.194  -7.142  -7.966  1.000 19.178  ? 267 THR A CB    1 ? 
ATOM   2087 O  OG1   . THR A 1 267 ? 16.171  -6.392  -8.672  1.000 21.072  ? 267 THR A OG1   1 ? 
ATOM   2088 C  CG2   . THR A 1 267 ? 13.817  -6.667  -8.364  1.000 19.289  ? 267 THR A CG2   1 ? 
ATOM   2089 N  N     . VAL A 1 268 ? 13.639  -6.388  -4.951  1.000 20.983  ? 268 VAL A N     1 ? 
ATOM   2090 C  CA    . VAL A 1 268 ? 12.437  -6.674  -4.112  1.000 20.744  ? 268 VAL A CA    1 ? 
ATOM   2091 C  C     . VAL A 1 268 ? 11.336  -5.667  -4.461  1.000 19.977  ? 268 VAL A C     1 ? 
ATOM   2092 O  O     . VAL A 1 268 ? 11.403  -4.514  -4.024  1.000 21.568  ? 268 VAL A O     1 ? 
ATOM   2093 C  CB    . VAL A 1 268 ? 12.783  -6.654  -2.618  1.000 22.138  ? 268 VAL A CB    1 ? 
ATOM   2094 C  CG1   . VAL A 1 268 ? 11.598  -7.062  -1.762  1.000 23.630  ? 268 VAL A CG1   1 ? 
ATOM   2095 C  CG2   . VAL A 1 268 ? 13.962  -7.557  -2.337  1.000 23.001  ? 268 VAL A CG2   1 ? 
ATOM   2096 N  N     . GLU A 1 269 ? 10.368  -6.107  -5.234  1.000 19.507  ? 269 GLU A N     1 ? 
ATOM   2097 C  CA    . GLU A 1 269 ? 9.207   -5.282  -5.633  1.000 24.084  ? 269 GLU A CA    1 ? 
ATOM   2098 C  C     . GLU A 1 269 ? 8.301   -5.106  -4.421  1.000 19.141  ? 269 GLU A C     1 ? 
ATOM   2099 O  O     . GLU A 1 269 ? 8.138   -6.031  -3.643  1.000 17.978  ? 269 GLU A O     1 ? 
ATOM   2100 C  CB    . GLU A 1 269 ? 8.541   -5.893  -6.861  1.000 28.058  ? 269 GLU A CB    1 ? 
ATOM   2101 C  CG    . GLU A 1 269 ? 9.505   -5.910  -8.039  1.000 33.258  ? 269 GLU A CG    1 ? 
ATOM   2102 C  CD    . GLU A 1 269 ? 8.940   -6.216  -9.414  1.000 39.074  ? 269 GLU A CD    1 ? 
ATOM   2103 O  OE1   . GLU A 1 269 ? 7.799   -6.725  -9.503  1.000 37.936  ? 269 GLU A OE1   1 ? 
ATOM   2104 O  OE2   . GLU A 1 269 ? 9.662   -5.937  -10.404 1.000 46.387  ? 269 GLU A OE2   1 ? 
ATOM   2105 N  N     . LEU A 1 270 ? 7.938   -3.876  -4.167  1.000 17.701  ? 270 LEU A N     1 ? 
ATOM   2106 C  CA    . LEU A 1 270 ? 6.873   -3.524  -3.220  1.000 17.494  ? 270 LEU A CA    1 ? 
ATOM   2107 C  C     . LEU A 1 270 ? 5.612   -4.280  -3.650  1.000 16.693  ? 270 LEU A C     1 ? 
ATOM   2108 O  O     . LEU A 1 270 ? 5.323   -4.352  -4.843  1.000 15.711  ? 270 LEU A O     1 ? 
ATOM   2109 C  CB    . LEU A 1 270 ? 6.735   -2.008  -3.299  1.000 17.238  ? 270 LEU A CB    1 ? 
ATOM   2110 C  CG    . LEU A 1 270 ? 6.130   -1.327  -2.094  1.000 17.309  ? 270 LEU A CG    1 ? 
ATOM   2111 C  CD1   . LEU A 1 270 ? 7.033   -1.431  -0.887  1.000 16.798  ? 270 LEU A CD1   1 ? 
ATOM   2112 C  CD2   . LEU A 1 270 ? 5.850   0.115   -2.423  1.000 17.767  ? 270 LEU A CD2   1 ? 
ATOM   2113 N  N     . PRO A 1 271 ? 4.889   -4.977  -2.736  1.000 16.868  ? 271 PRO A N     1 ? 
ATOM   2114 C  CA    . PRO A 1 271 ? 3.623   -5.631  -3.101  1.000 17.724  ? 271 PRO A CA    1 ? 
ATOM   2115 C  C     . PRO A 1 271 ? 2.403   -4.695  -3.264  1.000 17.580  ? 271 PRO A C     1 ? 
ATOM   2116 O  O     . PRO A 1 271 ? 1.313   -5.172  -3.496  1.000 20.791  ? 271 PRO A O     1 ? 
ATOM   2117 C  CB    . PRO A 1 271 ? 3.432   -6.611  -1.945  1.000 17.023  ? 271 PRO A CB    1 ? 
ATOM   2118 C  CG    . PRO A 1 271 ? 4.024   -5.884  -0.762  1.000 16.588  ? 271 PRO A CG    1 ? 
ATOM   2119 C  CD    . PRO A 1 271 ? 5.257   -5.222  -1.330  1.000 16.389  ? 271 PRO A CD    1 ? 
ATOM   2120 N  N     . VAL A 1 272 ? 2.615   -3.393  -3.213  1.000 16.411  ? 272 VAL A N     1 ? 
ATOM   2121 C  CA    . VAL A 1 272 ? 1.580   -2.352  -3.486  1.000 16.783  ? 272 VAL A CA    1 ? 
ATOM   2122 C  C     . VAL A 1 272 ? 2.208   -1.349  -4.446  1.000 18.291  ? 272 VAL A C     1 ? 
ATOM   2123 O  O     . VAL A 1 272 ? 3.424   -1.430  -4.616  1.000 16.705  ? 272 VAL A O     1 ? 
ATOM   2124 C  CB    . VAL A 1 272 ? 1.148   -1.669  -2.178  1.000 16.825  ? 272 VAL A CB    1 ? 
ATOM   2125 C  CG1   . VAL A 1 272 ? 0.565   -2.658  -1.179  1.000 16.437  ? 272 VAL A CG1   1 ? 
ATOM   2126 C  CG2   . VAL A 1 272 ? 2.294   -0.897  -1.543  1.000 16.694  ? 272 VAL A CG2   1 ? 
ATOM   2127 N  N     . GLN A 1 273 ? 1.433   -0.389  -4.951  1.000 20.150  ? 273 GLN A N     1 ? 
ATOM   2128 C  CA    . GLN A 1 273 ? 1.894   0.677   -5.883  1.000 23.446  ? 273 GLN A CA    1 ? 
ATOM   2129 C  C     . GLN A 1 273 ? 3.001   1.506   -5.241  1.000 24.757  ? 273 GLN A C     1 ? 
ATOM   2130 O  O     . GLN A 1 273 ? 2.899   1.898   -4.065  1.000 23.006  ? 273 GLN A O     1 ? 
ATOM   2131 C  CB    . GLN A 1 273 ? 0.751   1.628   -6.250  1.000 27.245  ? 273 GLN A CB    1 ? 
ATOM   2132 C  CG    . GLN A 1 273 ? -0.283  1.006   -7.176  1.000 30.809  ? 273 GLN A CG    1 ? 
ATOM   2133 C  CD    . GLN A 1 273 ? 0.089   1.085   -8.639  1.000 33.650  ? 273 GLN A CD    1 ? 
ATOM   2134 O  OE1   . GLN A 1 273 ? 1.044   1.758   -9.029  1.000 34.160  ? 273 GLN A OE1   1 ? 
ATOM   2135 N  NE2   . GLN A 1 273 ? -0.711  0.435   -9.474  1.000 32.978  ? 273 GLN A NE2   1 ? 
ATOM   2136 N  N     . PRO A 1 274 ? 4.039   1.919   -6.010  1.000 24.310  ? 274 PRO A N     1 ? 
ATOM   2137 C  CA    . PRO A 1 274 ? 4.158   1.636   -7.440  1.000 24.139  ? 274 PRO A CA    1 ? 
ATOM   2138 C  C     . PRO A 1 274 ? 4.798   0.301   -7.860  1.000 25.061  ? 274 PRO A C     1 ? 
ATOM   2139 O  O     . PRO A 1 274 ? 5.075   0.128   -9.006  1.000 23.376  ? 274 PRO A O     1 ? 
ATOM   2140 C  CB    . PRO A 1 274 ? 5.063   2.750   -7.979  1.000 23.707  ? 274 PRO A CB    1 ? 
ATOM   2141 C  CG    . PRO A 1 274 ? 5.641   3.468   -6.770  1.000 23.739  ? 274 PRO A CG    1 ? 
ATOM   2142 C  CD    . PRO A 1 274 ? 5.106   2.795   -5.529  1.000 25.405  ? 274 PRO A CD    1 ? 
ATOM   2143 N  N     . TYR A 1 275 ? 4.972   -0.635  -6.947  1.000 25.333  ? 275 TYR A N     1 ? 
ATOM   2144 C  CA    . TYR A 1 275 ? 5.654   -1.928  -7.226  1.000 27.679  ? 275 TYR A CA    1 ? 
ATOM   2145 C  C     . TYR A 1 275 ? 7.098   -1.667  -7.689  1.000 24.641  ? 275 TYR A C     1 ? 
ATOM   2146 O  O     . TYR A 1 275 ? 7.641   -2.470  -8.424  1.000 24.683  ? 275 TYR A O     1 ? 
ATOM   2147 C  CB    . TYR A 1 275 ? 4.886   -2.788  -8.243  1.000 29.104  ? 275 TYR A CB    1 ? 
ATOM   2148 C  CG    . TYR A 1 275 ? 3.397   -2.888  -8.009  1.000 31.385  ? 275 TYR A CG    1 ? 
ATOM   2149 C  CD1   . TYR A 1 275 ? 2.858   -3.784  -7.093  1.000 35.228  ? 275 TYR A CD1   1 ? 
ATOM   2150 C  CD2   . TYR A 1 275 ? 2.521   -2.060  -8.687  1.000 30.415  ? 275 TYR A CD2   1 ? 
ATOM   2151 C  CE1   . TYR A 1 275 ? 1.489   -3.842  -6.855  1.000 36.711  ? 275 TYR A CE1   1 ? 
ATOM   2152 C  CE2   . TYR A 1 275 ? 1.154   -2.116  -8.476  1.000 34.399  ? 275 TYR A CE2   1 ? 
ATOM   2153 C  CZ    . TYR A 1 275 ? 0.632   -3.006  -7.559  1.000 36.763  ? 275 TYR A CZ    1 ? 
ATOM   2154 O  OH    . TYR A 1 275 ? -0.713  -3.015  -7.350  1.000 32.962  ? 275 TYR A OH    1 ? 
ATOM   2155 N  N     . ASN A 1 276 ? 7.744   -0.611  -7.200  1.000 25.808  ? 276 ASN A N     1 ? 
ATOM   2156 C  CA    . ASN A 1 276 ? 9.185   -0.398  -7.495  1.000 26.125  ? 276 ASN A CA    1 ? 
ATOM   2157 C  C     . ASN A 1 276 ? 10.023  -1.465  -6.761  1.000 25.713  ? 276 ASN A C     1 ? 
ATOM   2158 O  O     . ASN A 1 276 ? 9.547   -2.060  -5.733  1.000 22.029  ? 276 ASN A O     1 ? 
ATOM   2159 C  CB    . ASN A 1 276 ? 9.659   1.001   -7.118  1.000 25.540  ? 276 ASN A CB    1 ? 
ATOM   2160 C  CG    . ASN A 1 276 ? 9.560   1.270   -5.634  1.000 27.488  ? 276 ASN A CG    1 ? 
ATOM   2161 O  OD1   . ASN A 1 276 ? 8.463   1.430   -5.113  1.000 29.090  ? 276 ASN A OD1   1 ? 
ATOM   2162 N  ND2   . ASN A 1 276 ? 10.687  1.295   -4.934  1.000 22.990  ? 276 ASN A ND2   1 ? 
ATOM   2163 N  N     . ASP A 1 277 ? 11.225  -1.697  -7.270  1.000 25.475  ? 277 ASP A N     1 ? 
ATOM   2164 C  CA    . ASP A 1 277 ? 12.320  -2.385  -6.563  1.000 26.806  ? 277 ASP A CA    1 ? 
ATOM   2165 C  C     . ASP A 1 277 ? 12.725  -1.454  -5.434  1.000 27.519  ? 277 ASP A C     1 ? 
ATOM   2166 O  O     . ASP A 1 277 ? 13.145  -0.336  -5.736  1.000 26.733  ? 277 ASP A O     1 ? 
ATOM   2167 C  CB    . ASP A 1 277 ? 13.478  -2.705  -7.516  1.000 27.294  ? 277 ASP A CB    1 ? 
ATOM   2168 C  CG    . ASP A 1 277 ? 14.713  -3.262  -6.833  1.000 27.726  ? 277 ASP A CG    1 ? 
ATOM   2169 O  OD1   . ASP A 1 277 ? 14.577  -3.815  -5.700  1.000 24.198  ? 277 ASP A OD1   1 ? 
ATOM   2170 O  OD2   . ASP A 1 277 ? 15.799  -3.155  -7.454  1.000 29.586  ? 277 ASP A OD2   1 ? 
ATOM   2171 N  N     . VAL A 1 278 ? 12.476  -1.847  -4.194  1.000 24.613  ? 278 VAL A N     1 ? 
ATOM   2172 C  CA    . VAL A 1 278 ? 12.720  -0.949  -3.036  1.000 28.474  ? 278 VAL A CA    1 ? 
ATOM   2173 C  C     . VAL A 1 278 ? 14.238  -0.685  -2.994  1.000 32.731  ? 278 VAL A C     1 ? 
ATOM   2174 O  O     . VAL A 1 278 ? 14.666  0.427   -2.609  1.000 34.683  ? 278 VAL A O     1 ? 
ATOM   2175 C  CB    . VAL A 1 278 ? 12.146  -1.559  -1.742  1.000 26.731  ? 278 VAL A CB    1 ? 
ATOM   2176 C  CG1   . VAL A 1 278 ? 10.635  -1.782  -1.834  1.000 26.044  ? 278 VAL A CG1   1 ? 
ATOM   2177 C  CG2   . VAL A 1 278 ? 12.825  -2.865  -1.392  1.000 27.094  ? 278 VAL A CG2   1 ? 
ATOM   2178 N  N     . PHE A 1 279 ? 15.023  -1.654  -3.461  1.000 35.820  ? 279 PHE A N     1 ? 
ATOM   2179 C  CA    . PHE A 1 279 ? 16.502  -1.655  -3.343  1.000 36.043  ? 279 PHE A CA    1 ? 
ATOM   2180 C  C     . PHE A 1 279 ? 17.143  -0.907  -4.519  1.000 36.323  ? 279 PHE A C     1 ? 
ATOM   2181 O  O     . PHE A 1 279 ? 18.367  -0.938  -4.629  1.000 40.077  ? 279 PHE A O     1 ? 
ATOM   2182 C  CB    . PHE A 1 279 ? 17.021  -3.089  -3.293  1.000 31.958  ? 279 PHE A CB    1 ? 
ATOM   2183 C  CG    . PHE A 1 279 ? 16.807  -3.803  -1.995  1.000 28.334  ? 279 PHE A CG    1 ? 
ATOM   2184 C  CD1   . PHE A 1 279 ? 17.179  -3.222  -0.802  1.000 30.671  ? 279 PHE A CD1   1 ? 
ATOM   2185 C  CD2   . PHE A 1 279 ? 16.222  -5.052  -1.964  1.000 28.325  ? 279 PHE A CD2   1 ? 
ATOM   2186 C  CE1   . PHE A 1 279 ? 16.996  -3.892  0.394   1.000 30.745  ? 279 PHE A CE1   1 ? 
ATOM   2187 C  CE2   . PHE A 1 279 ? 16.043  -5.725  -0.766  1.000 29.533  ? 279 PHE A CE2   1 ? 
ATOM   2188 C  CZ    . PHE A 1 279 ? 16.431  -5.145  0.408   1.000 31.526  ? 279 PHE A CZ    1 ? 
ATOM   2189 N  N     . GLU A 1 280 ? 16.353  -0.234  -5.350  1.000 39.882  ? 280 GLU A N     1 ? 
ATOM   2190 C  CA    . GLU A 1 280 ? 16.807  0.244   -6.686  1.000 46.329  ? 280 GLU A CA    1 ? 
ATOM   2191 C  C     . GLU A 1 280 ? 17.744  1.454   -6.547  1.000 50.181  ? 280 GLU A C     1 ? 
ATOM   2192 O  O     . GLU A 1 280 ? 18.421  1.763   -7.531  1.000 52.419  ? 280 GLU A O     1 ? 
ATOM   2193 C  CB    . GLU A 1 280 ? 15.615  0.557   -7.600  1.000 47.227  ? 280 GLU A CB    1 ? 
ATOM   2194 C  CG    . GLU A 1 280 ? 14.813  1.790   -7.196  1.000 51.964  ? 280 GLU A CG    1 ? 
ATOM   2195 C  CD    . GLU A 1 280 ? 13.421  1.885   -7.820  1.000 54.733  ? 280 GLU A CD    1 ? 
ATOM   2196 O  OE1   . GLU A 1 280 ? 13.139  1.132   -8.787  1.000 55.256  ? 280 GLU A OE1   1 ? 
ATOM   2197 O  OE2   . GLU A 1 280 ? 12.614  2.706   -7.333  1.000 53.502  ? 280 GLU A OE2   1 ? 
ATOM   2198 N  N     . LYS A 1 281 ? 17.784  2.121   -5.388  1.000 56.860  ? 281 LYS A N     1 ? 
ATOM   2199 C  CA    . LYS A 1 281 ? 18.593  3.361   -5.179  1.000 50.164  ? 281 LYS A CA    1 ? 
ATOM   2200 C  C     . LYS A 1 281 ? 19.864  3.027   -4.391  1.000 44.114  ? 281 LYS A C     1 ? 
ATOM   2201 O  O     . LYS A 1 281 ? 20.641  3.958   -4.113  1.000 42.816  ? 281 LYS A O     1 ? 
ATOM   2202 C  CB    . LYS A 1 281 ? 17.771  4.437   -4.460  1.000 55.621  ? 281 LYS A CB    1 ? 
ATOM   2203 C  CG    . LYS A 1 281 ? 16.754  5.176   -5.327  1.000 57.745  ? 281 LYS A CG    1 ? 
ATOM   2204 C  CD    . LYS A 1 281 ? 17.307  5.634   -6.673  1.000 57.356  ? 281 LYS A CD    1 ? 
ATOM   2205 C  CE    . LYS A 1 281 ? 16.551  6.807   -7.266  1.000 58.713  ? 281 LYS A CE    1 ? 
ATOM   2206 N  NZ    . LYS A 1 281 ? 15.138  6.465   -7.563  1.000 56.841  ? 281 LYS A NZ    1 ? 
ATOM   2207 N  N     . MET A 1 282 ? 20.073  1.751   -4.057  1.000 36.857  ? 282 MET A N     1 ? 
ATOM   2208 C  CA    . MET A 1 282 ? 21.379  1.231   -3.591  1.000 34.256  ? 282 MET A CA    1 ? 
ATOM   2209 C  C     . MET A 1 282 ? 22.306  1.030   -4.807  1.000 37.172  ? 282 MET A C     1 ? 
ATOM   2210 O  O     . MET A 1 282 ? 22.015  0.112   -5.644  1.000 36.985  ? 282 MET A O     1 ? 
ATOM   2211 C  CB    . MET A 1 282 ? 21.217  -0.110  -2.868  1.000 34.949  ? 282 MET A CB    1 ? 
ATOM   2212 C  CG    . MET A 1 282 ? 20.545  -0.014  -1.513  1.000 35.932  ? 282 MET A CG    1 ? 
ATOM   2213 S  SD    . MET A 1 282 ? 20.550  -1.586  -0.602  1.000 41.009  ? 282 MET A SD    1 ? 
ATOM   2214 C  CE    . MET A 1 282 ? 22.230  -2.159  -0.824  1.000 38.845  ? 282 MET A CE    1 ? 
ATOM   2215 N  N     . THR A 1 283 ? 23.390  1.811   -4.899  1.000 32.624  ? 283 THR A N     1 ? 
ATOM   2216 C  CA    . THR A 1 283 ? 24.485  1.607   -5.890  1.000 32.028  ? 283 THR A CA    1 ? 
ATOM   2217 C  C     . THR A 1 283 ? 24.947  0.149   -5.805  1.000 30.431  ? 283 THR A C     1 ? 
ATOM   2218 O  O     . THR A 1 283 ? 24.671  -0.497  -4.760  1.000 26.273  ? 283 THR A O     1 ? 
ATOM   2219 C  CB    . THR A 1 283 ? 25.655  2.572   -5.670  1.000 31.246  ? 283 THR A CB    1 ? 
ATOM   2220 O  OG1   . THR A 1 283 ? 26.064  2.432   -4.313  1.000 31.407  ? 283 THR A OG1   1 ? 
ATOM   2221 C  CG2   . THR A 1 283 ? 25.308  4.015   -5.967  1.000 32.377  ? 283 THR A CG2   1 ? 
ATOM   2222 N  N     . GLY A 1 284 ? 25.543  -0.366  -6.890  1.000 28.354  ? 284 GLY A N     1 ? 
ATOM   2223 C  CA    . GLY A 1 284 ? 26.026  -1.763  -7.005  1.000 26.412  ? 284 GLY A CA    1 ? 
ATOM   2224 C  C     . GLY A 1 284 ? 27.149  -2.025  -6.020  1.000 27.445  ? 284 GLY A C     1 ? 
ATOM   2225 O  O     . GLY A 1 284 ? 27.294  -3.197  -5.561  1.000 26.778  ? 284 GLY A O     1 ? 
ATOM   2226 N  N     . MET A 1 285 ? 27.918  -0.967  -5.709  1.000 26.255  ? 285 MET A N     1 ? 
ATOM   2227 C  CA    . MET A 1 285 ? 28.829  -0.907  -4.542  1.000 30.039  ? 285 MET A CA    1 ? 
ATOM   2228 C  C     . MET A 1 285 ? 27.992  -1.179  -3.281  1.000 29.195  ? 285 MET A C     1 ? 
ATOM   2229 O  O     . MET A 1 285 ? 28.201  -2.238  -2.683  1.000 27.155  ? 285 MET A O     1 ? 
ATOM   2230 C  CB    . MET A 1 285 ? 29.537  0.453   -4.426  1.000 32.495  ? 285 MET A CB    1 ? 
ATOM   2231 C  CG    . MET A 1 285 ? 30.013  1.029   -5.773  1.000 36.731  ? 285 MET A CG    1 ? 
ATOM   2232 S  SD    . MET A 1 285 ? 31.649  1.844   -5.718  1.000 41.717  ? 285 MET A SD    1 ? 
ATOM   2233 C  CE    . MET A 1 285 ? 31.462  2.997   -4.360  1.000 38.952  ? 285 MET A CE    1 ? 
ATOM   2234 N  N     . GLN A 1 286 ? 27.028  -0.303  -2.940  1.000 26.027  ? 286 GLN A N     1 ? 
ATOM   2235 C  CA    . GLN A 1 286 ? 26.197  -0.466  -1.696  1.000 26.409  ? 286 GLN A CA    1 ? 
ATOM   2236 C  C     . GLN A 1 286 ? 25.713  -1.921  -1.647  1.000 25.550  ? 286 GLN A C     1 ? 
ATOM   2237 O  O     . GLN A 1 286 ? 25.814  -2.548  -0.590  1.000 25.103  ? 286 GLN A O     1 ? 
ATOM   2238 C  CB    . GLN A 1 286 ? 25.030  0.526   -1.656  1.000 24.916  ? 286 GLN A CB    1 ? 
ATOM   2239 C  CG    . GLN A 1 286 ? 25.417  1.934   -1.231  1.000 25.432  ? 286 GLN A CG    1 ? 
ATOM   2240 C  CD    . GLN A 1 286 ? 24.287  2.924   -1.440  1.000 28.096  ? 286 GLN A CD    1 ? 
ATOM   2241 O  OE1   . GLN A 1 286 ? 23.851  3.181   -2.556  1.000 28.812  ? 286 GLN A OE1   1 ? 
ATOM   2242 N  NE2   . GLN A 1 286 ? 23.806  3.524   -0.364  1.000 32.084  ? 286 GLN A NE2   1 ? 
ATOM   2243 N  N     . MET A 1 287 ? 25.351  -2.478  -2.809  1.000 27.921  ? 287 MET A N     1 ? 
ATOM   2244 C  CA    . MET A 1 287 ? 24.644  -3.781  -2.948  1.000 26.822  ? 287 MET A CA    1 ? 
ATOM   2245 C  C     . MET A 1 287 ? 25.559  -4.965  -2.593  1.000 24.523  ? 287 MET A C     1 ? 
ATOM   2246 O  O     . MET A 1 287 ? 25.031  -5.972  -2.058  1.000 23.842  ? 287 MET A O     1 ? 
ATOM   2247 C  CB    . MET A 1 287 ? 24.102  -3.939  -4.375  1.000 28.594  ? 287 MET A CB    1 ? 
ATOM   2248 C  CG    . MET A 1 287 ? 22.651  -3.606  -4.487  1.000 29.639  ? 287 MET A CG    1 ? 
ATOM   2249 S  SD    . MET A 1 287 ? 21.608  -4.862  -3.699  1.000 36.744  ? 287 MET A SD    1 ? 
ATOM   2250 C  CE    . MET A 1 287 ? 20.130  -3.884  -3.491  1.000 32.957  ? 287 MET A CE    1 ? 
ATOM   2251 N  N     . GLU A 1 288 ? 26.846  -4.910  -2.955  1.000 25.663  ? 288 GLU A N     1 ? 
ATOM   2252 C  CA    . GLU A 1 288 ? 27.807  -6.033  -2.740  1.000 27.915  ? 288 GLU A CA    1 ? 
ATOM   2253 C  C     . GLU A 1 288 ? 28.180  -6.104  -1.252  1.000 25.760  ? 288 GLU A C     1 ? 
ATOM   2254 O  O     . GLU A 1 288 ? 28.338  -7.229  -0.739  1.000 18.706  ? 288 GLU A O     1 ? 
ATOM   2255 C  CB    . GLU A 1 288 ? 29.082  -5.866  -3.588  1.000 33.822  ? 288 GLU A CB    1 ? 
ATOM   2256 C  CG    . GLU A 1 288 ? 30.083  -7.030  -3.434  1.000 36.073  ? 288 GLU A CG    1 ? 
ATOM   2257 C  CD    . GLU A 1 288 ? 31.141  -7.174  -4.528  1.000 39.649  ? 288 GLU A CD    1 ? 
ATOM   2258 O  OE1   . GLU A 1 288 ? 31.175  -6.318  -5.444  1.000 38.504  ? 288 GLU A OE1   1 ? 
ATOM   2259 O  OE2   . GLU A 1 288 ? 31.894  -8.179  -4.496  1.000 39.269  ? 288 GLU A OE2   1 ? 
ATOM   2260 N  N     . SER A 1 289 ? 28.319  -4.958  -0.575  1.000 27.383  ? 289 SER A N     1 ? 
ATOM   2261 C  CA    . SER A 1 289 ? 28.666  -4.974  0.877   1.000 32.332  ? 289 SER A CA    1 ? 
ATOM   2262 C  C     . SER A 1 289 ? 27.423  -5.355  1.691   1.000 34.918  ? 289 SER A C     1 ? 
ATOM   2263 O  O     . SER A 1 289 ? 27.620  -6.034  2.720   1.000 38.202  ? 289 SER A O     1 ? 
ATOM   2264 C  CB    . SER A 1 289 ? 29.352  -3.707  1.369   1.000 33.459  ? 289 SER A CB    1 ? 
ATOM   2265 O  OG    . SER A 1 289 ? 28.780  -2.522  0.841   1.000 30.702  ? 289 SER A OG    1 ? 
ATOM   2266 N  N     . PHE A 1 290 ? 26.201  -5.079  1.185   1.000 33.645  ? 290 PHE A N     1 ? 
ATOM   2267 C  CA    . PHE A 1 290 ? 24.923  -5.642  1.732   1.000 31.871  ? 290 PHE A CA    1 ? 
ATOM   2268 C  C     . PHE A 1 290 ? 24.923  -7.189  1.641   1.000 27.617  ? 290 PHE A C     1 ? 
ATOM   2269 O  O     . PHE A 1 290 ? 24.544  -7.832  2.606   1.000 27.914  ? 290 PHE A O     1 ? 
ATOM   2270 C  CB    . PHE A 1 290 ? 23.679  -5.002  1.091   1.000 31.645  ? 290 PHE A CB    1 ? 
ATOM   2271 C  CG    . PHE A 1 290 ? 22.365  -5.686  1.409   1.000 33.737  ? 290 PHE A CG    1 ? 
ATOM   2272 C  CD1   . PHE A 1 290 ? 22.129  -6.266  2.650   1.000 33.554  ? 290 PHE A CD1   1 ? 
ATOM   2273 C  CD2   . PHE A 1 290 ? 21.361  -5.773  0.450   1.000 34.890  ? 290 PHE A CD2   1 ? 
ATOM   2274 C  CE1   . PHE A 1 290 ? 20.933  -6.921  2.914   1.000 38.101  ? 290 PHE A CE1   1 ? 
ATOM   2275 C  CE2   . PHE A 1 290 ? 20.163  -6.421  0.718   1.000 34.780  ? 290 PHE A CE2   1 ? 
ATOM   2276 C  CZ    . PHE A 1 290 ? 19.950  -6.996  1.949   1.000 37.649  ? 290 PHE A CZ    1 ? 
ATOM   2277 N  N     . LYS A 1 291 ? 25.340  -7.791  0.531   1.000 30.745  ? 291 LYS A N     1 ? 
ATOM   2278 C  CA    . LYS A 1 291 ? 25.320  -9.279  0.362   1.000 28.919  ? 291 LYS A CA    1 ? 
ATOM   2279 C  C     . LYS A 1 291 ? 26.469  -9.898  1.165   1.000 28.861  ? 291 LYS A C     1 ? 
ATOM   2280 O  O     . LYS A 1 291 ? 26.358  -11.090 1.556   1.000 22.545  ? 291 LYS A O     1 ? 
ATOM   2281 C  CB    . LYS A 1 291 ? 25.496  -9.684  -1.104  1.000 29.899  ? 291 LYS A CB    1 ? 
ATOM   2282 C  CG    . LYS A 1 291 ? 25.614  -11.186 -1.343  1.000 27.393  ? 291 LYS A CG    1 ? 
ATOM   2283 C  CD    . LYS A 1 291 ? 25.723  -11.534 -2.795  1.000 30.566  ? 291 LYS A CD    1 ? 
ATOM   2284 C  CE    . LYS A 1 291 ? 25.460  -12.993 -3.100  1.000 32.475  ? 291 LYS A CE    1 ? 
ATOM   2285 N  NZ    . LYS A 1 291 ? 25.940  -13.327 -4.459  1.000 34.871  ? 291 LYS A NZ    1 ? 
ATOM   2286 N  N     . SER A 1 292 ? 27.561  -9.138  1.327   1.000 28.109  ? 292 SER A N     1 ? 
ATOM   2287 C  CA    . SER A 1 292 ? 28.735  -9.547  2.133   1.000 30.972  ? 292 SER A CA    1 ? 
ATOM   2288 C  C     . SER A 1 292 ? 28.230  -9.774  3.569   1.000 26.522  ? 292 SER A C     1 ? 
ATOM   2289 O  O     . SER A 1 292 ? 28.206  -10.926 4.038   1.000 27.663  ? 292 SER A O     1 ? 
ATOM   2290 C  CB    . SER A 1 292 ? 29.843  -8.513  2.023   1.000 30.194  ? 292 SER A CB    1 ? 
ATOM   2291 O  OG    . SER A 1 292 ? 30.957  -8.849  2.846   1.000 38.331  ? 292 SER A OG    1 ? 
ATOM   2292 N  N     . LYS A 1 293 ? 27.582  -8.769  4.124   1.000 26.564  ? 293 LYS A N     1 ? 
ATOM   2293 C  CA    . LYS A 1 293 ? 27.115  -8.805  5.537   1.000 26.605  ? 293 LYS A CA    1 ? 
ATOM   2294 C  C     . LYS A 1 293 ? 26.033  -9.876  5.682   1.000 26.067  ? 293 LYS A C     1 ? 
ATOM   2295 O  O     . LYS A 1 293 ? 26.062  -10.585 6.706   1.000 26.252  ? 293 LYS A O     1 ? 
ATOM   2296 C  CB    . LYS A 1 293 ? 26.752  -7.385  5.975   1.000 24.035  ? 293 LYS A CB    1 ? 
ATOM   2297 C  CG    . LYS A 1 293 ? 27.987  -6.528  6.189   1.000 23.708  ? 293 LYS A CG    1 ? 
ATOM   2298 C  CD    . LYS A 1 293 ? 27.751  -5.138  6.695   1.000 25.603  ? 293 LYS A CD    1 ? 
ATOM   2299 C  CE    . LYS A 1 293 ? 27.345  -4.151  5.632   1.000 26.171  ? 293 LYS A CE    1 ? 
ATOM   2300 N  NZ    . LYS A 1 293 ? 27.719  -2.759  5.993   1.000 24.046  ? 293 LYS A NZ    1 ? 
ATOM   2301 N  N     . LEU A 1 294 ? 25.185  -10.071 4.652   1.000 29.399  ? 294 LEU A N     1 ? 
ATOM   2302 C  CA    . LEU A 1 294 ? 24.052  -11.051 4.687   1.000 27.388  ? 294 LEU A CA    1 ? 
ATOM   2303 C  C     . LEU A 1 294 ? 24.630  -12.454 4.764   1.000 26.834  ? 294 LEU A C     1 ? 
ATOM   2304 O  O     . LEU A 1 294 ? 24.077  -13.310 5.500   1.000 27.345  ? 294 LEU A O     1 ? 
ATOM   2305 C  CB    . LEU A 1 294 ? 23.182  -10.914 3.432   1.000 28.023  ? 294 LEU A CB    1 ? 
ATOM   2306 C  CG    . LEU A 1 294 ? 21.810  -10.273 3.609   1.000 28.917  ? 294 LEU A CG    1 ? 
ATOM   2307 C  CD1   . LEU A 1 294 ? 21.076  -10.258 2.277   1.000 30.018  ? 294 LEU A CD1   1 ? 
ATOM   2308 C  CD2   . LEU A 1 294 ? 20.976  -11.004 4.647   1.000 28.245  ? 294 LEU A CD2   1 ? 
ATOM   2309 N  N     . GLN A 1 295 ? 25.668  -12.694 3.963   1.000 28.709  ? 295 GLN A N     1 ? 
ATOM   2310 C  CA    . GLN A 1 295 ? 26.387  -13.989 3.932   1.000 30.447  ? 295 GLN A CA    1 ? 
ATOM   2311 C  C     . GLN A 1 295 ? 27.083  -14.191 5.287   1.000 27.635  ? 295 GLN A C     1 ? 
ATOM   2312 O  O     . GLN A 1 295 ? 26.997  -15.316 5.840   1.000 22.844  ? 295 GLN A O     1 ? 
ATOM   2313 C  CB    . GLN A 1 295 ? 27.362  -14.026 2.750   1.000 30.880  ? 295 GLN A CB    1 ? 
ATOM   2314 C  CG    . GLN A 1 295 ? 28.040  -15.377 2.583   1.000 30.648  ? 295 GLN A CG    1 ? 
ATOM   2315 C  CD    . GLN A 1 295 ? 27.121  -16.518 2.215   1.000 29.196  ? 295 GLN A CD    1 ? 
ATOM   2316 O  OE1   . GLN A 1 295 ? 26.805  -16.731 1.040   1.000 30.902  ? 295 GLN A OE1   1 ? 
ATOM   2317 N  NE2   . GLN A 1 295 ? 26.806  -17.343 3.198   1.000 27.977  ? 295 GLN A NE2   1 ? 
ATOM   2318 N  N     . ALA A 1 296 ? 27.745  -13.156 5.816   1.000 24.943  ? 296 ALA A N     1 ? 
ATOM   2319 C  CA    . ALA A 1 296 ? 28.366  -13.241 7.158   1.000 25.923  ? 296 ALA A CA    1 ? 
ATOM   2320 C  C     . ALA A 1 296 ? 27.270  -13.593 8.177   1.000 28.199  ? 296 ALA A C     1 ? 
ATOM   2321 O  O     . ALA A 1 296 ? 27.465  -14.541 8.936   1.000 32.800  ? 296 ALA A O     1 ? 
ATOM   2322 C  CB    . ALA A 1 296 ? 29.064  -11.954 7.504   1.000 28.668  ? 296 ALA A CB    1 ? 
ATOM   2323 N  N     . LEU A 1 297 ? 26.124  -12.892 8.146   1.000 25.713  ? 297 LEU A N     1 ? 
ATOM   2324 C  CA    . LEU A 1 297 ? 25.002  -13.163 9.082   1.000 23.560  ? 297 LEU A CA    1 ? 
ATOM   2325 C  C     . LEU A 1 297 ? 24.571  -14.614 8.926   1.000 21.125  ? 297 LEU A C     1 ? 
ATOM   2326 O  O     . LEU A 1 297 ? 24.279  -15.237 9.936   1.000 23.060  ? 297 LEU A O     1 ? 
ATOM   2327 C  CB    . LEU A 1 297 ? 23.830  -12.198 8.841   1.000 22.562  ? 297 LEU A CB    1 ? 
ATOM   2328 C  CG    . LEU A 1 297 ? 22.506  -12.560 9.516   1.000 22.952  ? 297 LEU A CG    1 ? 
ATOM   2329 C  CD1   . LEU A 1 297 ? 22.660  -12.727 11.029  1.000 23.839  ? 297 LEU A CD1   1 ? 
ATOM   2330 C  CD2   . LEU A 1 297 ? 21.449  -11.503 9.215   1.000 23.171  ? 297 LEU A CD2   1 ? 
ATOM   2331 N  N     . LEU A 1 298 ? 24.517  -15.139 7.707   1.000 22.557  ? 298 LEU A N     1 ? 
ATOM   2332 C  CA    . LEU A 1 298 ? 23.931  -16.488 7.477   1.000 21.967  ? 298 LEU A CA    1 ? 
ATOM   2333 C  C     . LEU A 1 298 ? 24.891  -17.555 8.020   1.000 23.563  ? 298 LEU A C     1 ? 
ATOM   2334 O  O     . LEU A 1 298 ? 24.408  -18.565 8.606   1.000 21.400  ? 298 LEU A O     1 ? 
ATOM   2335 C  CB    . LEU A 1 298 ? 23.640  -16.663 5.980   1.000 24.234  ? 298 LEU A CB    1 ? 
ATOM   2336 C  CG    . LEU A 1 298 ? 23.360  -18.096 5.508   1.000 26.406  ? 298 LEU A CG    1 ? 
ATOM   2337 C  CD1   . LEU A 1 298 ? 22.112  -18.699 6.150   1.000 25.946  ? 298 LEU A CD1   1 ? 
ATOM   2338 C  CD2   . LEU A 1 298 ? 23.259  -18.146 3.985   1.000 30.678  ? 298 LEU A CD2   1 ? 
ATOM   2339 N  N     . ASN A 1 299 ? 26.196  -17.354 7.855   1.000 24.082  ? 299 ASN A N     1 ? 
ATOM   2340 C  CA    . ASN A 1 299 ? 27.212  -18.340 8.333   1.000 27.898  ? 299 ASN A CA    1 ? 
ATOM   2341 C  C     . ASN A 1 299 ? 27.025  -18.507 9.850   1.000 29.279  ? 299 ASN A C     1 ? 
ATOM   2342 O  O     . ASN A 1 299 ? 26.789  -19.652 10.317  1.000 32.209  ? 299 ASN A O     1 ? 
ATOM   2343 C  CB    . ASN A 1 299 ? 28.620  -17.948 7.874   1.000 25.840  ? 299 ASN A CB    1 ? 
ATOM   2344 C  CG    . ASN A 1 299 ? 28.817  -18.088 6.370   1.000 30.901  ? 299 ASN A CG    1 ? 
ATOM   2345 O  OD1   . ASN A 1 299 ? 28.040  -18.758 5.683   1.000 32.505  ? 299 ASN A OD1   1 ? 
ATOM   2346 N  ND2   . ASN A 1 299 ? 29.868  -17.474 5.841   1.000 31.883  ? 299 ASN A ND2   1 ? 
ATOM   2347 N  N     . ALA A 1 300 ? 26.957  -17.389 10.576  1.000 32.186  ? 300 ALA A N     1 ? 
ATOM   2348 C  CA    . ALA A 1 300 ? 26.699  -17.362 12.036  1.000 31.045  ? 300 ALA A CA    1 ? 
ATOM   2349 C  C     . ALA A 1 300 ? 25.430  -18.164 12.374  1.000 30.494  ? 300 ALA A C     1 ? 
ATOM   2350 O  O     . ALA A 1 300 ? 25.452  -18.884 13.362  1.000 29.681  ? 300 ALA A O     1 ? 
ATOM   2351 C  CB    . ALA A 1 300 ? 26.602  -15.930 12.510  1.000 32.270  ? 300 ALA A CB    1 ? 
ATOM   2352 N  N     . LEU A 1 301 ? 24.338  -18.003 11.615  1.000 32.411  ? 301 LEU A N     1 ? 
ATOM   2353 C  CA    . LEU A 1 301 ? 23.036  -18.646 11.943  1.000 31.720  ? 301 LEU A CA    1 ? 
ATOM   2354 C  C     . LEU A 1 301 ? 23.169  -20.171 11.788  1.000 33.481  ? 301 LEU A C     1 ? 
ATOM   2355 O  O     . LEU A 1 301 ? 22.545  -20.906 12.556  1.000 33.212  ? 301 LEU A O     1 ? 
ATOM   2356 C  CB    . LEU A 1 301 ? 21.925  -18.087 11.037  1.000 32.297  ? 301 LEU A CB    1 ? 
ATOM   2357 C  CG    . LEU A 1 301 ? 21.498  -16.631 11.277  1.000 32.185  ? 301 LEU A CG    1 ? 
ATOM   2358 C  CD1   . LEU A 1 301 ? 20.542  -16.163 10.175  1.000 30.526  ? 301 LEU A CD1   1 ? 
ATOM   2359 C  CD2   . LEU A 1 301 ? 20.847  -16.443 12.654  1.000 30.637  ? 301 LEU A CD2   1 ? 
ATOM   2360 N  N     . LYS A 1 302 ? 23.927  -20.637 10.798  1.000 35.391  ? 302 LYS A N     1 ? 
ATOM   2361 C  CA    . LYS A 1 302 ? 24.160  -22.093 10.579  1.000 39.304  ? 302 LYS A CA    1 ? 
ATOM   2362 C  C     . LYS A 1 302 ? 24.949  -22.639 11.774  1.000 37.536  ? 302 LYS A C     1 ? 
ATOM   2363 O  O     . LYS A 1 302 ? 24.427  -23.550 12.481  1.000 33.592  ? 302 LYS A O     1 ? 
ATOM   2364 C  CB    . LYS A 1 302 ? 24.885  -22.309 9.245   1.000 41.871  ? 302 LYS A CB    1 ? 
ATOM   2365 C  CG    . LYS A 1 302 ? 24.099  -21.847 8.022   1.000 41.345  ? 302 LYS A CG    1 ? 
ATOM   2366 C  CD    . LYS A 1 302 ? 24.735  -22.196 6.697   1.000 39.973  ? 302 LYS A CD    1 ? 
ATOM   2367 C  CE    . LYS A 1 302 ? 23.719  -22.236 5.570   1.000 39.980  ? 302 LYS A CE    1 ? 
ATOM   2368 N  NZ    . LYS A 1 302 ? 24.319  -21.851 4.275   1.000 39.027  ? 302 LYS A NZ    1 ? 
ATOM   2369 N  N     . THR A 1 303 ? 26.119  -22.027 12.017  1.000 39.824  ? 303 THR A N     1 ? 
ATOM   2370 C  CA    . THR A 1 303 ? 27.021  -22.251 13.177  1.000 41.935  ? 303 THR A CA    1 ? 
ATOM   2371 C  C     . THR A 1 303 ? 26.220  -22.542 14.450  1.000 42.591  ? 303 THR A C     1 ? 
ATOM   2372 O  O     . THR A 1 303 ? 26.573  -23.502 15.126  1.000 48.028  ? 303 THR A O     1 ? 
ATOM   2373 C  CB    . THR A 1 303 ? 27.915  -21.026 13.389  1.000 43.719  ? 303 THR A CB    1 ? 
ATOM   2374 O  OG1   . THR A 1 303 ? 28.588  -20.765 12.163  1.000 44.445  ? 303 THR A OG1   1 ? 
ATOM   2375 C  CG2   . THR A 1 303 ? 28.939  -21.212 14.479  1.000 47.072  ? 303 THR A CG2   1 ? 
ATOM   2376 N  N     . ALA A 1 304 ? 25.200  -21.724 14.766  1.000 44.738  ? 304 ALA A N     1 ? 
ATOM   2377 C  CA    . ALA A 1 304 ? 24.493  -21.688 16.076  1.000 42.034  ? 304 ALA A CA    1 ? 
ATOM   2378 C  C     . ALA A 1 304 ? 23.562  -22.896 16.240  1.000 43.548  ? 304 ALA A C     1 ? 
ATOM   2379 O  O     . ALA A 1 304 ? 23.139  -23.149 17.393  1.000 39.531  ? 304 ALA A O     1 ? 
ATOM   2380 C  CB    . ALA A 1 304 ? 23.719  -20.398 16.223  1.000 41.685  ? 304 ALA A CB    1 ? 
ATOM   2381 N  N     . LYS A 1 305 ? 23.234  -23.598 15.145  1.000 43.176  ? 305 LYS A N     1 ? 
ATOM   2382 C  CA    . LYS A 1 305 ? 22.225  -24.696 15.133  1.000 44.262  ? 305 LYS A CA    1 ? 
ATOM   2383 C  C     . LYS A 1 305 ? 22.760  -25.902 15.921  1.000 50.416  ? 305 LYS A C     1 ? 
ATOM   2384 O  O     . LYS A 1 305 ? 21.929  -26.639 16.514  1.000 46.159  ? 305 LYS A O     1 ? 
ATOM   2385 C  CB    . LYS A 1 305 ? 21.882  -25.099 13.696  1.000 44.489  ? 305 LYS A CB    1 ? 
ATOM   2386 C  CG    . LYS A 1 305 ? 20.639  -25.973 13.563  1.000 47.996  ? 305 LYS A CG    1 ? 
ATOM   2387 C  CD    . LYS A 1 305 ? 20.587  -26.838 12.294  1.000 48.985  ? 305 LYS A CD    1 ? 
ATOM   2388 C  CE    . LYS A 1 305 ? 19.378  -27.759 12.234  1.000 49.882  ? 305 LYS A CE    1 ? 
ATOM   2389 N  NZ    . LYS A 1 305 ? 18.826  -28.073 13.581  1.000 47.509  ? 305 LYS A NZ    1 ? 
ATOM   2390 N  N     . SER A 1 306 ? 24.083  -26.120 15.898  1.000 55.877  ? 306 SER A N     1 ? 
ATOM   2391 C  CA    . SER A 1 306 ? 24.771  -27.197 16.659  1.000 62.871  ? 306 SER A CA    1 ? 
ATOM   2392 C  C     . SER A 1 306 ? 26.244  -26.863 16.879  1.000 62.117  ? 306 SER A C     1 ? 
ATOM   2393 O  O     . SER A 1 306 ? 26.655  -26.826 18.044  1.000 66.931  ? 306 SER A O     1 ? 
ATOM   2394 C  CB    . SER A 1 306 ? 24.642  -28.520 15.961  1.000 70.566  ? 306 SER A CB    1 ? 
ATOM   2395 O  OG    . SER A 1 306 ? 25.788  -28.781 15.155  1.000 74.791  ? 306 SER A OG    1 ? 
ATOM   2396 N  N     . ARG A 1 307 ? 27.011  -26.733 15.790  1.000 63.741  ? 307 ARG A N     1 ? 
ATOM   2397 C  CA    . ARG A 1 307 ? 28.499  -26.813 15.788  1.000 67.288  ? 307 ARG A CA    1 ? 
ATOM   2398 C  C     . ARG A 1 307 ? 29.007  -26.326 17.156  1.000 61.788  ? 307 ARG A C     1 ? 
ATOM   2399 O  O     . ARG A 1 307 ? 29.526  -27.172 17.928  1.000 61.760  ? 307 ARG A O     1 ? 
ATOM   2400 C  CB    . ARG A 1 307 ? 29.064  -26.091 14.548  1.000 73.617  ? 307 ARG A CB    1 ? 
ATOM   2401 C  CG    . ARG A 1 307 ? 30.185  -25.085 14.801  1.000 86.522  ? 307 ARG A CG    1 ? 
ATOM   2402 C  CD    . ARG A 1 307 ? 31.585  -25.487 14.343  1.000 89.978  ? 307 ARG A CD    1 ? 
ATOM   2403 N  NE    . ARG A 1 307 ? 32.595  -24.567 14.885  1.000 95.622  ? 307 ARG A NE    1 ? 
ATOM   2404 C  CZ    . ARG A 1 307 ? 33.043  -23.448 14.292  1.000 96.501  ? 307 ARG A CZ    1 ? 
ATOM   2405 N  NH1   . ARG A 1 307 ? 32.598  -23.084 13.099  1.000 93.690  ? 307 ARG A NH1   1 ? 
ATOM   2406 N  NH2   . ARG A 1 307 ? 33.944  -22.693 14.904  1.000 92.188  ? 307 ARG A NH2   1 ? 
ATOM   2407 N  N     . LEU A 1 308 ? 28.782  -25.050 17.481  1.000 51.904  ? 308 LEU A N     1 ? 
ATOM   2408 C  CA    . LEU A 1 308 ? 29.352  -24.381 18.682  1.000 54.726  ? 308 LEU A CA    1 ? 
ATOM   2409 C  C     . LEU A 1 308 ? 28.380  -24.547 19.863  1.000 57.798  ? 308 LEU A C     1 ? 
ATOM   2410 O  O     . LEU A 1 308 ? 27.165  -24.662 19.596  1.000 68.620  ? 308 LEU A O     1 ? 
ATOM   2411 C  CB    . LEU A 1 308 ? 29.590  -22.898 18.354  1.000 53.232  ? 308 LEU A CB    1 ? 
ATOM   2412 C  CG    . LEU A 1 308 ? 31.014  -22.472 17.973  1.000 51.869  ? 308 LEU A CG    1 ? 
ATOM   2413 C  CD1   . LEU A 1 308 ? 32.050  -23.569 18.198  1.000 48.565  ? 308 LEU A CD1   1 ? 
ATOM   2414 C  CD2   . LEU A 1 308 ? 31.060  -21.981 16.543  1.000 49.777  ? 308 LEU A CD2   1 ? 
ATOM   2415 N  N     . GLU A 1 309 ? 28.875  -24.540 21.115  1.000 52.986  ? 309 GLU A N     1 ? 
ATOM   2416 C  CA    . GLU A 1 309 ? 28.016  -24.633 22.336  1.000 56.732  ? 309 GLU A CA    1 ? 
ATOM   2417 C  C     . GLU A 1 309 ? 27.590  -23.226 22.804  1.000 51.739  ? 309 GLU A C     1 ? 
ATOM   2418 O  O     . GLU A 1 309 ? 28.233  -22.233 22.394  1.000 42.179  ? 309 GLU A O     1 ? 
ATOM   2419 C  CB    . GLU A 1 309 ? 28.702  -25.437 23.444  1.000 61.270  ? 309 GLU A CB    1 ? 
ATOM   2420 C  CG    . GLU A 1 309 ? 27.740  -26.363 24.192  1.000 63.501  ? 309 GLU A CG    1 ? 
ATOM   2421 C  CD    . GLU A 1 309 ? 26.801  -27.197 23.318  1.000 62.576  ? 309 GLU A CD    1 ? 
ATOM   2422 O  OE1   . GLU A 1 309 ? 27.281  -28.133 22.639  1.000 62.582  ? 309 GLU A OE1   1 ? 
ATOM   2423 O  OE2   . GLU A 1 309 ? 25.590  -26.905 23.305  1.000 61.427  ? 309 GLU A OE2   1 ? 
ATOM   2424 N  N     . LEU A 1 310 ? 26.515  -23.154 23.606  1.000 48.511  ? 310 LEU A N     1 ? 
ATOM   2425 C  CA    . LEU A 1 310 ? 25.605  -21.975 23.660  1.000 46.461  ? 310 LEU A CA    1 ? 
ATOM   2426 C  C     . LEU A 1 310 ? 26.445  -20.692 23.634  1.000 47.722  ? 310 LEU A C     1 ? 
ATOM   2427 O  O     . LEU A 1 310 ? 26.122  -19.789 22.813  1.000 48.739  ? 310 LEU A O     1 ? 
ATOM   2428 C  CB    . LEU A 1 310 ? 24.718  -22.041 24.908  1.000 47.783  ? 310 LEU A CB    1 ? 
ATOM   2429 C  CG    . LEU A 1 310 ? 23.497  -21.113 24.911  1.000 51.087  ? 310 LEU A CG    1 ? 
ATOM   2430 C  CD1   . LEU A 1 310 ? 22.587  -21.402 23.724  1.000 54.115  ? 310 LEU A CD1   1 ? 
ATOM   2431 C  CD2   . LEU A 1 310 ? 22.699  -21.240 26.208  1.000 49.090  ? 310 LEU A CD2   1 ? 
ATOM   2432 N  N     . HIS A 1 311 ? 27.499  -20.620 24.461  1.000 40.523  ? 311 HIS A N     1 ? 
ATOM   2433 C  CA    . HIS A 1 311 ? 28.340  -19.410 24.636  1.000 35.577  ? 311 HIS A CA    1 ? 
ATOM   2434 C  C     . HIS A 1 311 ? 28.915  -18.972 23.276  1.000 35.324  ? 311 HIS A C     1 ? 
ATOM   2435 O  O     . HIS A 1 311 ? 28.692  -17.807 22.876  1.000 34.665  ? 311 HIS A O     1 ? 
ATOM   2436 C  CB    . HIS A 1 311 ? 29.421  -19.643 25.696  1.000 33.701  ? 311 HIS A CB    1 ? 
ATOM   2437 C  CG    . HIS A 1 311 ? 30.362  -18.494 25.824  1.000 32.083  ? 311 HIS A CG    1 ? 
ATOM   2438 N  ND1   . HIS A 1 311 ? 30.017  -17.330 26.481  1.000 33.950  ? 311 HIS A ND1   1 ? 
ATOM   2439 C  CD2   . HIS A 1 311 ? 31.595  -18.289 25.320  1.000 30.862  ? 311 HIS A CD2   1 ? 
ATOM   2440 C  CE1   . HIS A 1 311 ? 31.014  -16.471 26.410  1.000 35.287  ? 311 HIS A CE1   1 ? 
ATOM   2441 N  NE2   . HIS A 1 311 ? 31.998  -17.042 25.711  1.000 32.598  ? 311 HIS A NE2   1 ? 
ATOM   2442 N  N     . ASP A 1 312 ? 29.621  -19.859 22.578  1.000 38.934  ? 312 ASP A N     1 ? 
ATOM   2443 C  CA    . ASP A 1 312 ? 30.278  -19.528 21.282  1.000 41.406  ? 312 ASP A CA    1 ? 
ATOM   2444 C  C     . ASP A 1 312 ? 29.204  -19.347 20.201  1.000 43.171  ? 312 ASP A C     1 ? 
ATOM   2445 O  O     . ASP A 1 312 ? 29.379  -18.428 19.368  1.000 42.954  ? 312 ASP A O     1 ? 
ATOM   2446 C  CB    . ASP A 1 312 ? 31.326  -20.563 20.866  1.000 45.348  ? 312 ASP A CB    1 ? 
ATOM   2447 C  CG    . ASP A 1 312 ? 32.474  -20.724 21.853  1.000 47.473  ? 312 ASP A CG    1 ? 
ATOM   2448 O  OD1   . ASP A 1 312 ? 33.047  -19.693 22.266  1.000 49.622  ? 312 ASP A OD1   1 ? 
ATOM   2449 O  OD2   . ASP A 1 312 ? 32.763  -21.883 22.229  1.000 52.099  ? 312 ASP A OD2   1 ? 
ATOM   2450 N  N     . ALA A 1 313 ? 28.149  -20.179 20.205  1.000 38.260  ? 313 ALA A N     1 ? 
ATOM   2451 C  CA    . ALA A 1 313 ? 26.933  -19.955 19.389  1.000 43.886  ? 313 ALA A CA    1 ? 
ATOM   2452 C  C     . ALA A 1 313 ? 26.615  -18.459 19.481  1.000 44.004  ? 313 ALA A C     1 ? 
ATOM   2453 O  O     . ALA A 1 313 ? 27.103  -17.684 18.588  1.000 39.245  ? 313 ALA A O     1 ? 
ATOM   2454 C  CB    . ALA A 1 313 ? 25.760  -20.821 19.851  1.000 36.832  ? 313 ALA A CB    1 ? 
ATOM   2455 N  N     . CYS A 1 314 ? 25.964  -18.083 20.592  1.000 40.243  ? 314 CYS A N     1 ? 
ATOM   2456 C  CA    . CYS A 1 314 ? 25.477  -16.726 20.935  1.000 37.370  ? 314 CYS A CA    1 ? 
ATOM   2457 C  C     . CYS A 1 314 ? 26.566  -15.695 20.685  1.000 38.199  ? 314 CYS A C     1 ? 
ATOM   2458 O  O     . CYS A 1 314 ? 26.224  -14.580 20.245  1.000 39.410  ? 314 CYS A O     1 ? 
ATOM   2459 C  CB    . CYS A 1 314 ? 25.063  -16.671 22.397  1.000 35.146  ? 314 CYS A CB    1 ? 
ATOM   2460 S  SG    . CYS A 1 314 ? 23.530  -17.564 22.694  1.000 31.291  ? 314 CYS A SG    1 ? 
ATOM   2461 N  N     . LYS A 1 315 ? 27.813  -16.060 20.995  1.000 38.574  ? 315 LYS A N     1 ? 
ATOM   2462 C  CA    . LYS A 1 315 ? 29.007  -15.201 20.808  1.000 41.584  ? 315 LYS A CA    1 ? 
ATOM   2463 C  C     . LYS A 1 315 ? 29.136  -14.811 19.331  1.000 38.194  ? 315 LYS A C     1 ? 
ATOM   2464 O  O     . LYS A 1 315 ? 29.497  -13.642 19.059  1.000 35.219  ? 315 LYS A O     1 ? 
ATOM   2465 C  CB    . LYS A 1 315 ? 30.272  -15.921 21.279  1.000 46.600  ? 315 LYS A CB    1 ? 
ATOM   2466 C  CG    . LYS A 1 315 ? 31.493  -15.034 21.453  1.000 49.354  ? 315 LYS A CG    1 ? 
ATOM   2467 C  CD    . LYS A 1 315 ? 32.692  -15.779 21.993  1.000 55.380  ? 315 LYS A CD    1 ? 
ATOM   2468 C  CE    . LYS A 1 315 ? 33.960  -14.960 21.922  1.000 59.552  ? 315 LYS A CE    1 ? 
ATOM   2469 N  NZ    . LYS A 1 315 ? 33.811  -13.675 22.644  1.000 63.121  ? 315 LYS A NZ    1 ? 
ATOM   2470 N  N     . ALA A 1 316 ? 28.895  -15.761 18.423  1.000 38.001  ? 316 ALA A N     1 ? 
ATOM   2471 C  CA    . ALA A 1 316 ? 28.944  -15.564 16.950  1.000 37.765  ? 316 ALA A CA    1 ? 
ATOM   2472 C  C     . ALA A 1 316 ? 27.862  -14.554 16.524  1.000 33.455  ? 316 ALA A C     1 ? 
ATOM   2473 O  O     . ALA A 1 316 ? 28.212  -13.490 15.940  1.000 33.110  ? 316 ALA A O     1 ? 
ATOM   2474 C  CB    . ALA A 1 316 ? 28.758  -16.894 16.256  1.000 37.914  ? 316 ALA A CB    1 ? 
ATOM   2475 N  N     . LEU A 1 317 ? 26.609  -14.856 16.884  1.000 32.795  ? 317 LEU A N     1 ? 
ATOM   2476 C  CA    . LEU A 1 317 ? 25.383  -14.076 16.575  1.000 27.733  ? 317 LEU A CA    1 ? 
ATOM   2477 C  C     . LEU A 1 317 ? 25.609  -12.613 16.939  1.000 30.782  ? 317 LEU A C     1 ? 
ATOM   2478 O  O     . LEU A 1 317 ? 25.167  -11.745 16.138  1.000 23.797  ? 317 LEU A O     1 ? 
ATOM   2479 C  CB    . LEU A 1 317 ? 24.209  -14.700 17.327  1.000 30.111  ? 317 LEU A CB    1 ? 
ATOM   2480 C  CG    . LEU A 1 317 ? 23.904  -16.160 16.942  1.000 31.547  ? 317 LEU A CG    1 ? 
ATOM   2481 C  CD1   . LEU A 1 317 ? 22.636  -16.675 17.607  1.000 29.171  ? 317 LEU A CD1   1 ? 
ATOM   2482 C  CD2   . LEU A 1 317 ? 23.786  -16.318 15.422  1.000 35.384  ? 317 LEU A CD2   1 ? 
ATOM   2483 N  N     . ALA A 1 318 ? 26.399  -12.359 17.998  1.000 29.282  ? 318 ALA A N     1 ? 
ATOM   2484 C  CA    . ALA A 1 318 ? 26.613  -11.019 18.579  1.000 31.282  ? 318 ALA A CA    1 ? 
ATOM   2485 C  C     . ALA A 1 318 ? 27.556  -10.205 17.681  1.000 33.332  ? 318 ALA A C     1 ? 
ATOM   2486 O  O     . ALA A 1 318 ? 27.458  -8.945  17.671  1.000 27.566  ? 318 ALA A O     1 ? 
ATOM   2487 C  CB    . ALA A 1 318 ? 27.130  -11.141 19.997  1.000 34.572  ? 318 ALA A CB    1 ? 
ATOM   2488 N  N     . ASP A 1 319 ? 28.368  -10.859 16.857  1.000 35.256  ? 319 ASP A N     1 ? 
ATOM   2489 C  CA    . ASP A 1 319 ? 29.108  -10.117 15.801  1.000 34.568  ? 319 ASP A CA    1 ? 
ATOM   2490 C  C     . ASP A 1 319 ? 28.084  -9.469  14.861  1.000 30.303  ? 319 ASP A C     1 ? 
ATOM   2491 O  O     . ASP A 1 319 ? 28.391  -8.394  14.303  1.000 27.557  ? 319 ASP A O     1 ? 
ATOM   2492 C  CB    . ASP A 1 319 ? 30.096  -11.003 15.039  1.000 38.911  ? 319 ASP A CB    1 ? 
ATOM   2493 C  CG    . ASP A 1 319 ? 31.347  -11.345 15.825  1.000 39.130  ? 319 ASP A CG    1 ? 
ATOM   2494 O  OD1   . ASP A 1 319 ? 32.087  -12.235 15.371  1.000 44.980  ? 319 ASP A OD1   1 ? 
ATOM   2495 O  OD2   . ASP A 1 319 ? 31.568  -10.724 16.882  1.000 42.413  ? 319 ASP A OD2   1 ? 
ATOM   2496 N  N     . HIS A 1 320 ? 26.905  -10.081 14.719  1.000 28.857  ? 320 HIS A N     1 ? 
ATOM   2497 C  CA    . HIS A 1 320 ? 25.858  -9.687  13.725  1.000 28.926  ? 320 HIS A CA    1 ? 
ATOM   2498 C  C     . HIS A 1 320 ? 24.733  -8.865  14.392  1.000 26.367  ? 320 HIS A C     1 ? 
ATOM   2499 O  O     . HIS A 1 320 ? 24.368  -7.805  13.843  1.000 25.150  ? 320 HIS A O     1 ? 
ATOM   2500 C  CB    . HIS A 1 320 ? 25.396  -10.943 12.982  1.000 28.722  ? 320 HIS A CB    1 ? 
ATOM   2501 C  CG    . HIS A 1 320 ? 26.539  -11.625 12.312  1.000 27.124  ? 320 HIS A CG    1 ? 
ATOM   2502 N  ND1   . HIS A 1 320 ? 27.239  -11.030 11.295  1.000 27.626  ? 320 HIS A ND1   1 ? 
ATOM   2503 C  CD2   . HIS A 1 320 ? 27.179  -12.779 12.589  1.000 28.099  ? 320 HIS A CD2   1 ? 
ATOM   2504 C  CE1   . HIS A 1 320 ? 28.250  -11.800 10.950  1.000 27.943  ? 320 HIS A CE1   1 ? 
ATOM   2505 N  NE2   . HIS A 1 320 ? 28.216  -12.890 11.711  1.000 28.779  ? 320 HIS A NE2   1 ? 
ATOM   2506 N  N     . PHE A 1 321 ? 24.294  -9.270  15.587  1.000 27.786  ? 321 PHE A N     1 ? 
ATOM   2507 C  CA    . PHE A 1 321 ? 23.083  -8.745  16.290  1.000 25.604  ? 321 PHE A CA    1 ? 
ATOM   2508 C  C     . PHE A 1 321 ? 23.439  -7.699  17.345  1.000 24.596  ? 321 PHE A C     1 ? 
ATOM   2509 O  O     . PHE A 1 321 ? 22.565  -6.901  17.671  1.000 23.363  ? 321 PHE A O     1 ? 
ATOM   2510 C  CB    . PHE A 1 321 ? 22.297  -9.894  16.900  1.000 23.574  ? 321 PHE A CB    1 ? 
ATOM   2511 C  CG    . PHE A 1 321 ? 21.501  -10.667 15.883  1.000 23.929  ? 321 PHE A CG    1 ? 
ATOM   2512 C  CD1   . PHE A 1 321 ? 20.655  -10.015 14.979  1.000 22.303  ? 321 PHE A CD1   1 ? 
ATOM   2513 C  CD2   . PHE A 1 321 ? 21.591  -12.048 15.823  1.000 23.618  ? 321 PHE A CD2   1 ? 
ATOM   2514 C  CE1   . PHE A 1 321 ? 19.926  -10.738 14.046  1.000 21.438  ? 321 PHE A CE1   1 ? 
ATOM   2515 C  CE2   . PHE A 1 321 ? 20.851  -12.763 14.893  1.000 22.926  ? 321 PHE A CE2   1 ? 
ATOM   2516 C  CZ    . PHE A 1 321 ? 20.035  -12.106 13.997  1.000 21.018  ? 321 PHE A CZ    1 ? 
ATOM   2517 N  N     . GLY A 1 322 ? 24.680  -7.703  17.830  1.000 23.545  ? 322 GLY A N     1 ? 
ATOM   2518 C  CA    . GLY A 1 322 ? 25.220  -6.656  18.702  1.000 24.831  ? 322 GLY A CA    1 ? 
ATOM   2519 C  C     . GLY A 1 322 ? 25.267  -7.089  20.152  1.000 21.441  ? 322 GLY A C     1 ? 
ATOM   2520 O  O     . GLY A 1 322 ? 24.906  -8.242  20.477  1.000 19.890  ? 322 GLY A O     1 ? 
ATOM   2521 N  N     . SER A 1 323 ? 25.717  -6.196  21.005  1.000 23.318  ? 323 SER A N     1 ? 
ATOM   2522 C  CA    . SER A 1 323 ? 26.079  -6.529  22.408  1.000 24.770  ? 323 SER A CA    1 ? 
ATOM   2523 C  C     . SER A 1 323 ? 24.823  -6.667  23.263  1.000 23.366  ? 323 SER A C     1 ? 
ATOM   2524 O  O     . SER A 1 323 ? 24.977  -6.977  24.443  1.000 27.248  ? 323 SER A O     1 ? 
ATOM   2525 C  CB    . SER A 1 323 ? 27.037  -5.527  22.953  1.000 25.625  ? 323 SER A CB    1 ? 
ATOM   2526 O  OG    . SER A 1 323 ? 26.509  -4.218  22.778  1.000 28.085  ? 323 SER A OG    1 ? 
ATOM   2527 N  N     . GLU A 1 324 ? 23.617  -6.506  22.684  1.000 26.010  ? 324 GLU A N     1 ? 
ATOM   2528 C  CA    . GLU A 1 324 ? 22.331  -6.815  23.376  1.000 24.904  ? 324 GLU A CA    1 ? 
ATOM   2529 C  C     . GLU A 1 324 ? 21.893  -8.248  23.067  1.000 23.535  ? 324 GLU A C     1 ? 
ATOM   2530 O  O     . GLU A 1 324 ? 20.949  -8.730  23.710  1.000 22.366  ? 324 GLU A O     1 ? 
ATOM   2531 C  CB    . GLU A 1 324 ? 21.231  -5.827  23.019  1.000 26.346  ? 324 GLU A CB    1 ? 
ATOM   2532 C  CG    . GLU A 1 324 ? 21.460  -4.448  23.586  1.000 30.482  ? 324 GLU A CG    1 ? 
ATOM   2533 C  CD    . GLU A 1 324 ? 20.217  -3.572  23.721  1.000 36.351  ? 324 GLU A CD    1 ? 
ATOM   2534 O  OE1   . GLU A 1 324 ? 19.186  -3.848  23.049  1.000 38.401  ? 324 GLU A OE1   1 ? 
ATOM   2535 O  OE2   . GLU A 1 324 ? 20.285  -2.595  24.479  1.000 42.255  ? 324 GLU A OE2   1 ? 
ATOM   2536 N  N     . PHE A 1 325 ? 22.534  -8.933  22.133  1.000 23.971  ? 325 PHE A N     1 ? 
ATOM   2537 C  CA    . PHE A 1 325 ? 22.266  -10.379 21.973  1.000 23.113  ? 325 PHE A CA    1 ? 
ATOM   2538 C  C     . PHE A 1 325 ? 22.802  -11.023 23.234  1.000 24.051  ? 325 PHE A C     1 ? 
ATOM   2539 O  O     . PHE A 1 325 ? 23.980  -10.820 23.564  1.000 21.724  ? 325 PHE A O     1 ? 
ATOM   2540 C  CB    . PHE A 1 325 ? 22.865  -11.003 20.705  1.000 20.755  ? 325 PHE A CB    1 ? 
ATOM   2541 C  CG    . PHE A 1 325 ? 22.246  -12.343 20.420  1.000 20.782  ? 325 PHE A CG    1 ? 
ATOM   2542 C  CD1   . PHE A 1 325 ? 22.788  -13.506 20.946  1.000 21.372  ? 325 PHE A CD1   1 ? 
ATOM   2543 C  CD2   . PHE A 1 325 ? 21.033  -12.433 19.743  1.000 20.396  ? 325 PHE A CD2   1 ? 
ATOM   2544 C  CE1   . PHE A 1 325 ? 22.135  -14.722 20.795  1.000 21.643  ? 325 PHE A CE1   1 ? 
ATOM   2545 C  CE2   . PHE A 1 325 ? 20.403  -13.657 19.557  1.000 18.996  ? 325 PHE A CE2   1 ? 
ATOM   2546 C  CZ    . PHE A 1 325 ? 20.953  -14.801 20.081  1.000 21.136  ? 325 PHE A CZ    1 ? 
ATOM   2547 N  N     . PRO A 1 326 ? 21.944  -11.727 24.009  1.000 26.362  ? 326 PRO A N     1 ? 
ATOM   2548 C  CA    . PRO A 1 326 ? 22.364  -12.335 25.269  1.000 26.249  ? 326 PRO A CA    1 ? 
ATOM   2549 C  C     . PRO A 1 326 ? 23.391  -13.427 24.967  1.000 26.753  ? 326 PRO A C     1 ? 
ATOM   2550 O  O     . PRO A 1 326 ? 23.190  -14.163 24.017  1.000 25.373  ? 326 PRO A O     1 ? 
ATOM   2551 C  CB    . PRO A 1 326 ? 21.091  -12.906 25.908  1.000 26.209  ? 326 PRO A CB    1 ? 
ATOM   2552 C  CG    . PRO A 1 326 ? 20.109  -13.020 24.747  1.000 27.902  ? 326 PRO A CG    1 ? 
ATOM   2553 C  CD    . PRO A 1 326 ? 20.517  -11.956 23.739  1.000 27.003  ? 326 PRO A CD    1 ? 
ATOM   2554 N  N     . VAL A 1 327 ? 24.516  -13.387 25.681  1.000 25.208  ? 327 VAL A N     1 ? 
ATOM   2555 C  CA    . VAL A 1 327 ? 25.575  -14.426 25.641  1.000 28.033  ? 327 VAL A CA    1 ? 
ATOM   2556 C  C     . VAL A 1 327 ? 25.692  -14.988 27.050  1.000 29.936  ? 327 VAL A C     1 ? 
ATOM   2557 O  O     . VAL A 1 327 ? 25.951  -14.247 27.991  1.000 26.548  ? 327 VAL A O     1 ? 
ATOM   2558 C  CB    . VAL A 1 327 ? 26.912  -13.854 25.129  1.000 29.841  ? 327 VAL A CB    1 ? 
ATOM   2559 C  CG1   . VAL A 1 327 ? 28.071  -14.828 25.317  1.000 29.872  ? 327 VAL A CG1   1 ? 
ATOM   2560 C  CG2   . VAL A 1 327 ? 26.815  -13.423 23.668  1.000 30.481  ? 327 VAL A CG2   1 ? 
ATOM   2561 N  N     . PRO A 1 328 ? 25.431  -16.293 27.259  1.000 32.956  ? 328 PRO A N     1 ? 
ATOM   2562 C  CA    . PRO A 1 328 ? 25.731  -16.923 28.539  1.000 34.900  ? 328 PRO A CA    1 ? 
ATOM   2563 C  C     . PRO A 1 328 ? 27.252  -17.001 28.722  1.000 37.164  ? 328 PRO A C     1 ? 
ATOM   2564 O  O     . PRO A 1 328 ? 27.955  -17.115 27.735  1.000 30.712  ? 328 PRO A O     1 ? 
ATOM   2565 C  CB    . PRO A 1 328 ? 25.100  -18.316 28.436  1.000 36.294  ? 328 PRO A CB    1 ? 
ATOM   2566 C  CG    . PRO A 1 328 ? 24.167  -18.222 27.242  1.000 35.270  ? 328 PRO A CG    1 ? 
ATOM   2567 C  CD    . PRO A 1 328 ? 24.813  -17.219 26.308  1.000 31.634  ? 328 PRO A CD    1 ? 
ATOM   2568 N  N     . GLU A 1 329 ? 27.719  -16.899 29.967  1.000 42.749  ? 329 GLU A N     1 ? 
ATOM   2569 C  CA    . GLU A 1 329 ? 29.147  -17.094 30.341  1.000 46.940  ? 329 GLU A CA    1 ? 
ATOM   2570 C  C     . GLU A 1 329 ? 29.540  -18.544 30.048  1.000 45.223  ? 329 GLU A C     1 ? 
ATOM   2571 O  O     . GLU A 1 329 ? 28.655  -19.415 30.167  1.000 42.856  ? 329 GLU A O     1 ? 
ATOM   2572 C  CB    . GLU A 1 329 ? 29.337  -16.765 31.815  1.000 50.223  ? 329 GLU A CB    1 ? 
ATOM   2573 C  CG    . GLU A 1 329 ? 28.871  -15.366 32.181  1.000 54.233  ? 329 GLU A CG    1 ? 
ATOM   2574 C  CD    . GLU A 1 329 ? 29.262  -14.947 33.587  1.000 59.168  ? 329 GLU A CD    1 ? 
ATOM   2575 O  OE1   . GLU A 1 329 ? 30.475  -14.942 33.879  1.000 63.963  ? 329 GLU A OE1   1 ? 
ATOM   2576 O  OE2   . GLU A 1 329 ? 28.354  -14.651 34.394  1.000 59.155  ? 329 GLU A OE2   1 ? 
ATOM   2577 N  N     . LYS A 1 330 ? 30.797  -18.796 29.665  1.000 47.164  ? 330 LYS A N     1 ? 
ATOM   2578 C  CA    . LYS A 1 330 ? 31.314  -20.176 29.454  1.000 56.723  ? 330 LYS A CA    1 ? 
ATOM   2579 C  C     . LYS A 1 330 ? 31.928  -20.683 30.763  1.000 53.806  ? 330 LYS A C     1 ? 
ATOM   2580 O  O     . LYS A 1 330 ? 31.689  -21.837 31.113  1.000 62.053  ? 330 LYS A O     1 ? 
ATOM   2581 C  CB    . LYS A 1 330 ? 32.313  -20.246 28.290  1.000 65.087  ? 330 LYS A CB    1 ? 
ATOM   2582 C  CG    . LYS A 1 330 ? 32.198  -21.514 27.443  1.000 73.229  ? 330 LYS A CG    1 ? 
ATOM   2583 C  CD    . LYS A 1 330 ? 33.203  -21.639 26.298  1.000 79.299  ? 330 LYS A CD    1 ? 
ATOM   2584 C  CE    . LYS A 1 330 ? 33.015  -22.917 25.494  1.000 82.179  ? 330 LYS A CE    1 ? 
ATOM   2585 N  NZ    . LYS A 1 330 ? 34.050  -23.094 24.443  1.000 80.169  ? 330 LYS A NZ    1 ? 
HETATM 2586 P  PG    . GTP B 2 .   ? 12.452  0.904   9.945   1.000 44.853  ? 401 GTP A PG    1 ? 
HETATM 2587 O  O1G   . GTP B 2 .   ? 13.658  0.376   9.233   1.000 44.108  ? 401 GTP A O1G   1 ? 
HETATM 2588 O  O2G   . GTP B 2 .   ? 12.385  2.446   9.968   1.000 31.607  ? 401 GTP A O2G   1 ? 
HETATM 2589 O  O3G   . GTP B 2 .   ? 12.261  0.272   11.317  1.000 44.570  ? 401 GTP A O3G   1 ? 
HETATM 2590 O  O3B   . GTP B 2 .   ? 11.229  0.297   9.076   1.000 44.554  ? 401 GTP A O3B   1 ? 
HETATM 2591 P  PB    . GTP B 2 .   ? 10.117  0.987   8.174   1.000 46.351  ? 401 GTP A PB    1 ? 
HETATM 2592 O  O1B   . GTP B 2 .   ? 9.317   -0.082  7.488   1.000 48.415  ? 401 GTP A O1B   1 ? 
HETATM 2593 O  O2B   . GTP B 2 .   ? 9.437   1.999   9.014   1.000 44.140  ? 401 GTP A O2B   1 ? 
HETATM 2594 O  O3A   . GTP B 2 .   ? 11.070  1.708   7.100   1.000 51.534  ? 401 GTP A O3A   1 ? 
HETATM 2595 P  PA    . GTP B 2 .   ? 11.474  3.186   6.574   1.000 56.114  ? 401 GTP A PA    1 ? 
HETATM 2596 O  O1A   . GTP B 2 .   ? 11.556  4.137   7.722   1.000 50.272  ? 401 GTP A O1A   1 ? 
HETATM 2597 O  O2A   . GTP B 2 .   ? 12.673  3.005   5.703   1.000 58.836  ? 401 GTP A O2A   1 ? 
HETATM 2598 O  "O5'" . GTP B 2 .   ? 10.218  3.601   5.656   1.000 51.455  ? 401 GTP A "O5'" 1 ? 
HETATM 2599 C  "C5'" . GTP B 2 .   ? 9.015   4.079   6.315   1.000 49.173  ? 401 GTP A "C5'" 1 ? 
HETATM 2600 C  "C4'" . GTP B 2 .   ? 7.825   3.840   5.423   1.000 46.073  ? 401 GTP A "C4'" 1 ? 
HETATM 2601 O  "O4'" . GTP B 2 .   ? 7.987   4.599   4.200   1.000 43.683  ? 401 GTP A "O4'" 1 ? 
HETATM 2602 C  "C3'" . GTP B 2 .   ? 7.625   2.399   4.944   1.000 45.342  ? 401 GTP A "C3'" 1 ? 
HETATM 2603 O  "O3'" . GTP B 2 .   ? 6.976   1.603   5.926   1.000 46.656  ? 401 GTP A "O3'" 1 ? 
HETATM 2604 C  "C2'" . GTP B 2 .   ? 6.787   2.626   3.680   1.000 46.515  ? 401 GTP A "C2'" 1 ? 
HETATM 2605 O  "O2'" . GTP B 2 .   ? 5.417   2.816   3.946   1.000 44.963  ? 401 GTP A "O2'" 1 ? 
HETATM 2606 C  "C1'" . GTP B 2 .   ? 7.455   3.882   3.105   1.000 44.438  ? 401 GTP A "C1'" 1 ? 
HETATM 2607 N  N9    . GTP B 2 .   ? 8.532   3.567   2.169   1.000 39.814  ? 401 GTP A N9    1 ? 
HETATM 2608 C  C8    . GTP B 2 .   ? 9.855   3.341   2.479   1.000 40.378  ? 401 GTP A C8    1 ? 
HETATM 2609 N  N7    . GTP B 2 .   ? 10.582  3.016   1.436   1.000 37.875  ? 401 GTP A N7    1 ? 
HETATM 2610 C  C5    . GTP B 2 .   ? 9.679   3.000   0.377   1.000 37.031  ? 401 GTP A C5    1 ? 
HETATM 2611 C  C6    . GTP B 2 .   ? 9.891   2.716   -0.993  1.000 36.527  ? 401 GTP A C6    1 ? 
HETATM 2612 O  O6    . GTP B 2 .   ? 10.948  2.394   -1.548  1.000 32.865  ? 401 GTP A O6    1 ? 
HETATM 2613 N  N1    . GTP B 2 .   ? 8.709   2.817   -1.727  1.000 38.384  ? 401 GTP A N1    1 ? 
HETATM 2614 C  C2    . GTP B 2 .   ? 7.483   3.151   -1.209  1.000 42.231  ? 401 GTP A C2    1 ? 
HETATM 2615 N  N2    . GTP B 2 .   ? 6.460   3.211   -2.081  1.000 42.662  ? 401 GTP A N2    1 ? 
HETATM 2616 N  N3    . GTP B 2 .   ? 7.281   3.423   0.083   1.000 37.202  ? 401 GTP A N3    1 ? 
HETATM 2617 C  C4    . GTP B 2 .   ? 8.415   3.331   0.813   1.000 37.692  ? 401 GTP A C4    1 ? 
HETATM 2618 P  PG    . GTP C 2 .   ? 18.306  8.909   -2.151  1.000 106.725 ? 402 GTP A PG    1 ? 
HETATM 2619 O  O1G   . GTP C 2 .   ? 17.827  7.674   -2.881  1.000 98.967  ? 402 GTP A O1G   1 ? 
HETATM 2620 O  O2G   . GTP C 2 .   ? 18.192  10.153  -2.996  1.000 109.037 ? 402 GTP A O2G   1 ? 
HETATM 2621 O  O3G   . GTP C 2 .   ? 19.687  8.737   -1.560  1.000 107.449 ? 402 GTP A O3G   1 ? 
HETATM 2622 O  O3B   . GTP C 2 .   ? 17.305  9.124   -0.876  1.000 106.327 ? 402 GTP A O3B   1 ? 
HETATM 2623 P  PB    . GTP C 2 .   ? 17.298  10.109  0.396   1.000 101.460 ? 402 GTP A PB    1 ? 
HETATM 2624 O  O1B   . GTP C 2 .   ? 18.679  10.149  0.971   1.000 101.844 ? 402 GTP A O1B   1 ? 
HETATM 2625 O  O2B   . GTP C 2 .   ? 16.652  11.389  -0.019  1.000 101.429 ? 402 GTP A O2B   1 ? 
HETATM 2626 O  O3A   . GTP C 2 .   ? 16.332  9.348   1.438   1.000 94.315  ? 402 GTP A O3A   1 ? 
HETATM 2627 P  PA    . GTP C 2 .   ? 14.984  8.458   1.370   1.000 91.226  ? 402 GTP A PA    1 ? 
HETATM 2628 O  O1A   . GTP C 2 .   ? 13.806  9.360   1.214   1.000 75.925  ? 402 GTP A O1A   1 ? 
HETATM 2629 O  O2A   . GTP C 2 .   ? 15.152  7.375   0.356   1.000 94.935  ? 402 GTP A O2A   1 ? 
HETATM 2630 O  "O5'" . GTP C 2 .   ? 14.956  7.798   2.838   1.000 91.464  ? 402 GTP A "O5'" 1 ? 
HETATM 2631 C  "C5'" . GTP C 2 .   ? 14.666  8.607   4.010   1.000 83.068  ? 402 GTP A "C5'" 1 ? 
HETATM 2632 C  "C4'" . GTP C 2 .   ? 13.369  8.154   4.640   1.000 79.745  ? 402 GTP A "C4'" 1 ? 
HETATM 2633 O  "O4'" . GTP C 2 .   ? 12.280  8.402   3.722   1.000 79.193  ? 402 GTP A "O4'" 1 ? 
HETATM 2634 C  "C3'" . GTP C 2 .   ? 13.262  6.665   4.978   1.000 78.315  ? 402 GTP A "C3'" 1 ? 
HETATM 2635 O  "O3'" . GTP C 2 .   ? 13.781  6.435   6.284   1.000 67.836  ? 402 GTP A "O3'" 1 ? 
HETATM 2636 C  "C2'" . GTP C 2 .   ? 11.752  6.395   4.887   1.000 77.245  ? 402 GTP A "C2'" 1 ? 
HETATM 2637 O  "O2'" . GTP C 2 .   ? 11.123  6.555   6.140   1.000 71.893  ? 402 GTP A "O2'" 1 ? 
HETATM 2638 C  "C1'" . GTP C 2 .   ? 11.251  7.450   3.895   1.000 79.215  ? 402 GTP A "C1'" 1 ? 
HETATM 2639 N  N9    . GTP C 2 .   ? 10.901  6.946   2.568   1.000 79.859  ? 402 GTP A N9    1 ? 
HETATM 2640 C  C8    . GTP C 2 .   ? 11.779  6.549   1.587   1.000 79.753  ? 402 GTP A C8    1 ? 
HETATM 2641 N  N7    . GTP C 2 .   ? 11.194  6.207   0.465   1.000 71.986  ? 402 GTP A N7    1 ? 
HETATM 2642 C  C5    . GTP C 2 .   ? 9.841   6.399   0.716   1.000 72.280  ? 402 GTP A C5    1 ? 
HETATM 2643 C  C6    . GTP C 2 .   ? 8.722   6.195   -0.133  1.000 70.822  ? 402 GTP A C6    1 ? 
HETATM 2644 O  O6    . GTP C 2 .   ? 8.708   5.807   -1.310  1.000 68.247  ? 402 GTP A O6    1 ? 
HETATM 2645 N  N1    . GTP C 2 .   ? 7.528   6.504   0.520   1.000 70.593  ? 402 GTP A N1    1 ? 
HETATM 2646 C  C2    . GTP C 2 .   ? 7.421   6.963   1.812   1.000 67.518  ? 402 GTP A C2    1 ? 
HETATM 2647 N  N2    . GTP C 2 .   ? 6.179   7.198   2.257   1.000 71.688  ? 402 GTP A N2    1 ? 
HETATM 2648 N  N3    . GTP C 2 .   ? 8.470   7.170   2.613   1.000 68.835  ? 402 GTP A N3    1 ? 
HETATM 2649 C  C4    . GTP C 2 .   ? 9.645   6.862   2.004   1.000 74.472  ? 402 GTP A C4    1 ? 
HETATM 2650 MG MG    . MG  D 3 .   ? 10.702  3.639   9.784   1.000 32.393  ? 403 MG  A MG    1 ? 
HETATM 2651 MG MG    . MG  E 3 .   ? 12.466  6.834   8.110   1.000 37.348  ? 404 MG  A MG    1 ? 
HETATM 2652 O  O     . HOH F 4 .   ? 1.304   -20.758 9.050   1.000 22.901  ? 501 HOH A O     1 ? 
HETATM 2653 O  O     . HOH F 4 .   ? 5.464   -21.399 1.919   1.000 38.465  ? 502 HOH A O     1 ? 
HETATM 2654 O  O     . HOH F 4 .   ? 4.174   2.622   5.788   1.000 30.835  ? 503 HOH A O     1 ? 
HETATM 2655 O  O     . HOH F 4 .   ? 27.492  -27.829 20.348  1.000 39.482  ? 504 HOH A O     1 ? 
HETATM 2656 O  O     . HOH F 4 .   ? 29.244  5.637   24.524  1.000 35.754  ? 505 HOH A O     1 ? 
HETATM 2657 O  O     . HOH F 4 .   ? 6.596   -12.634 19.513  1.000 19.856  ? 506 HOH A O     1 ? 
HETATM 2658 O  O     . HOH F 4 .   ? 12.212  -3.672  24.674  1.000 24.197  ? 507 HOH A O     1 ? 
HETATM 2659 O  O     . HOH F 4 .   ? 32.850  -7.668  -12.916 1.000 34.355  ? 508 HOH A O     1 ? 
HETATM 2660 O  O     . HOH F 4 .   ? 16.813  -23.595 20.502  1.000 30.512  ? 509 HOH A O     1 ? 
HETATM 2661 O  O     . HOH F 4 .   ? 18.224  -0.797  16.604  1.000 20.273  ? 510 HOH A O     1 ? 
HETATM 2662 O  O     . HOH F 4 .   ? 1.938   -8.836  11.660  1.000 36.803  ? 511 HOH A O     1 ? 
HETATM 2663 O  O     . HOH F 4 .   ? 19.466  8.480   2.633   1.000 33.715  ? 512 HOH A O     1 ? 
HETATM 2664 O  O     . HOH F 4 .   ? 11.613  -18.082 6.814   1.000 23.273  ? 513 HOH A O     1 ? 
HETATM 2665 O  O     . HOH F 4 .   ? 17.322  -2.147  22.905  1.000 22.461  ? 514 HOH A O     1 ? 
HETATM 2666 O  O     . HOH F 4 .   ? 5.493   -17.283 17.615  1.000 20.951  ? 515 HOH A O     1 ? 
HETATM 2667 O  O     . HOH F 4 .   ? 10.430  3.370   11.877  1.000 20.535  ? 516 HOH A O     1 ? 
HETATM 2668 O  O     . HOH F 4 .   ? 12.577  27.263  0.679   1.000 41.328  ? 517 HOH A O     1 ? 
HETATM 2669 O  O     . HOH F 4 .   ? 31.495  -8.267  -7.065  1.000 37.732  ? 518 HOH A O     1 ? 
HETATM 2670 O  O     . HOH F 4 .   ? 10.358  -18.100 0.539   1.000 45.289  ? 519 HOH A O     1 ? 
HETATM 2671 O  O     . HOH F 4 .   ? 12.513  0.386   13.864  1.000 13.985  ? 520 HOH A O     1 ? 
HETATM 2672 O  O     . HOH F 4 .   ? 3.888   -2.924  20.328  1.000 18.445  ? 521 HOH A O     1 ? 
HETATM 2673 O  O     . HOH F 4 .   ? 15.976  25.883  -1.467  1.000 49.554  ? 522 HOH A O     1 ? 
HETATM 2674 O  O     . HOH F 4 .   ? 20.828  11.574  0.596   1.000 34.364  ? 523 HOH A O     1 ? 
HETATM 2675 O  O     . HOH F 4 .   ? 3.182   30.214  14.560  1.000 43.753  ? 524 HOH A O     1 ? 
HETATM 2676 O  O     . HOH F 4 .   ? 4.999   1.715   25.806  1.000 34.401  ? 525 HOH A O     1 ? 
HETATM 2677 O  O     . HOH F 4 .   ? 12.657  2.742   24.078  1.000 34.915  ? 526 HOH A O     1 ? 
HETATM 2678 O  O     . HOH F 4 .   ? 18.358  -3.730  -6.808  1.000 14.149  ? 527 HOH A O     1 ? 
HETATM 2679 O  O     . HOH F 4 .   ? -2.366  -35.883 24.245  1.000 36.585  ? 528 HOH A O     1 ? 
HETATM 2680 O  O     . HOH F 4 .   ? 1.121   -10.676 9.599   1.000 32.234  ? 529 HOH A O     1 ? 
HETATM 2681 O  O     . HOH F 4 .   ? 3.517   2.665   -1.588  1.000 34.240  ? 530 HOH A O     1 ? 
HETATM 2682 O  O     . HOH F 4 .   ? 17.693  -22.707 18.330  1.000 25.545  ? 531 HOH A O     1 ? 
HETATM 2683 O  O     . HOH F 4 .   ? 17.316  21.129  2.256   1.000 34.432  ? 532 HOH A O     1 ? 
HETATM 2684 O  O     . HOH F 4 .   ? 5.037   2.448   1.263   1.000 30.920  ? 533 HOH A O     1 ? 
HETATM 2685 O  O     . HOH F 4 .   ? 3.679   -7.372  19.234  1.000 29.436  ? 534 HOH A O     1 ? 
HETATM 2686 O  O     . HOH F 4 .   ? 15.905  5.872   -2.181  1.000 37.318  ? 535 HOH A O     1 ? 
HETATM 2687 O  O     . HOH F 4 .   ? 26.808  -6.496  26.406  1.000 33.479  ? 536 HOH A O     1 ? 
HETATM 2688 O  O     . HOH F 4 .   ? 14.862  -7.864  29.116  1.000 23.130  ? 537 HOH A O     1 ? 
HETATM 2689 O  O     . HOH F 4 .   ? -0.299  11.890  22.137  1.000 33.589  ? 538 HOH A O     1 ? 
HETATM 2690 O  O     . HOH F 4 .   ? 20.326  2.665   16.131  1.000 27.858  ? 539 HOH A O     1 ? 
HETATM 2691 O  O     . HOH F 4 .   ? 27.773  -22.111 26.773  1.000 30.211  ? 540 HOH A O     1 ? 
HETATM 2692 O  O     . HOH F 4 .   ? 0.866   -7.802  -4.237  1.000 43.700  ? 541 HOH A O     1 ? 
HETATM 2693 O  O     . HOH F 4 .   ? 11.947  -18.298 4.322   1.000 28.411  ? 542 HOH A O     1 ? 
HETATM 2694 O  O     . HOH F 4 .   ? 10.245  -12.431 22.754  1.000 25.897  ? 543 HOH A O     1 ? 
HETATM 2695 O  O     . HOH F 4 .   ? 17.793  -9.748  30.737  1.000 24.293  ? 544 HOH A O     1 ? 
HETATM 2696 O  O     . HOH F 4 .   ? 22.924  5.760   26.509  1.000 48.740  ? 545 HOH A O     1 ? 
HETATM 2697 O  O     . HOH F 4 .   ? 32.743  -10.822 1.904   1.000 29.084  ? 546 HOH A O     1 ? 
HETATM 2698 O  O     . HOH F 4 .   ? 4.965   -17.269 5.542   1.000 23.831  ? 547 HOH A O     1 ? 
HETATM 2699 O  O     . HOH F 4 .   ? -3.004  -3.569  -4.326  1.000 34.716  ? 548 HOH A O     1 ? 
HETATM 2700 O  O     . HOH F 4 .   ? 15.005  3.509   9.668   1.000 32.353  ? 549 HOH A O     1 ? 
HETATM 2701 O  O     . HOH F 4 .   ? 16.896  19.165  -0.812  1.000 61.099  ? 550 HOH A O     1 ? 
HETATM 2702 O  O     . HOH F 4 .   ? 19.360  -15.408 -9.112  1.000 35.324  ? 551 HOH A O     1 ? 
HETATM 2703 O  O     . HOH F 4 .   ? 22.675  -5.079  19.959  1.000 37.779  ? 552 HOH A O     1 ? 
HETATM 2704 O  O     . HOH F 4 .   ? 27.291  7.439   22.303  1.000 52.085  ? 553 HOH A O     1 ? 
HETATM 2705 O  O     . HOH F 4 .   ? 24.850  -2.715  -18.936 1.000 25.260  ? 554 HOH A O     1 ? 
HETATM 2706 O  O     . HOH F 4 .   ? 9.094   21.062  19.690  1.000 43.726  ? 555 HOH A O     1 ? 
HETATM 2707 O  O     . HOH F 4 .   ? 17.962  0.370   23.073  1.000 30.152  ? 556 HOH A O     1 ? 
HETATM 2708 O  O     . HOH F 4 .   ? 18.453  12.948  -16.609 1.000 46.508  ? 557 HOH A O     1 ? 
HETATM 2709 O  O     . HOH F 4 .   ? 24.696  -1.615  2.028   1.000 20.972  ? 558 HOH A O     1 ? 
HETATM 2710 O  O     . HOH F 4 .   ? -3.776  25.924  15.024  1.000 46.550  ? 559 HOH A O     1 ? 
HETATM 2711 O  O     . HOH F 4 .   ? 2.566   16.625  -11.600 1.000 46.915  ? 560 HOH A O     1 ? 
HETATM 2712 O  O     . HOH F 4 .   ? -1.985  13.965  22.204  1.000 47.085  ? 561 HOH A O     1 ? 
HETATM 2713 O  O     . HOH F 4 .   ? 10.447  -16.092 -5.256  1.000 43.710  ? 562 HOH A O     1 ? 
HETATM 2714 O  O     . HOH F 4 .   ? 5.593   31.528  1.782   1.000 34.695  ? 563 HOH A O     1 ? 
HETATM 2715 O  O     . HOH F 4 .   ? 7.925   -25.202 10.044  1.000 34.611  ? 564 HOH A O     1 ? 
HETATM 2716 O  O     . HOH F 4 .   ? 0.495   -21.298 17.215  1.000 29.914  ? 565 HOH A O     1 ? 
HETATM 2717 O  O     . HOH F 4 .   ? 7.652   4.558   12.126  1.000 35.450  ? 566 HOH A O     1 ? 
HETATM 2718 O  O     . HOH F 4 .   ? 0.592   -6.556  15.466  1.000 27.066  ? 567 HOH A O     1 ? 
HETATM 2719 O  O     . HOH F 4 .   ? 32.152  -17.736 18.088  1.000 30.234  ? 568 HOH A O     1 ? 
HETATM 2720 O  O     . HOH F 4 .   ? 4.924   5.148   26.477  1.000 41.466  ? 569 HOH A O     1 ? 
HETATM 2721 O  O     . HOH F 4 .   ? 27.512  4.989   21.182  1.000 49.625  ? 570 HOH A O     1 ? 
HETATM 2722 O  O     . HOH F 4 .   ? 24.847  -19.214 0.615   1.000 39.311  ? 571 HOH A O     1 ? 
HETATM 2723 O  O     . HOH F 4 .   ? 24.365  -1.447  -9.808  1.000 17.533  ? 572 HOH A O     1 ? 
HETATM 2724 O  O     . HOH F 4 .   ? 3.088   7.190   -10.741 1.000 23.659  ? 573 HOH A O     1 ? 
HETATM 2725 O  O     . HOH F 4 .   ? 19.368  -5.230  -10.313 1.000 36.177  ? 574 HOH A O     1 ? 
HETATM 2726 O  O     . HOH F 4 .   ? 32.303  -16.765 7.816   1.000 28.233  ? 575 HOH A O     1 ? 
HETATM 2727 O  O     . HOH F 4 .   ? 24.489  -14.948 -8.413  1.000 27.152  ? 576 HOH A O     1 ? 
HETATM 2728 O  O     . HOH F 4 .   ? -3.958  -2.354  17.393  1.000 36.733  ? 577 HOH A O     1 ? 
HETATM 2729 O  O     . HOH F 4 .   ? -1.330  -19.168 16.981  1.000 33.462  ? 578 HOH A O     1 ? 
HETATM 2730 O  O     . HOH F 4 .   ? 4.723   -19.798 6.390   1.000 22.734  ? 579 HOH A O     1 ? 
HETATM 2731 O  O     . HOH F 4 .   ? -2.924  8.134   18.405  1.000 43.002  ? 580 HOH A O     1 ? 
HETATM 2732 O  O     . HOH F 4 .   ? 24.836  -3.161  19.975  1.000 32.854  ? 581 HOH A O     1 ? 
HETATM 2733 O  O     . HOH F 4 .   ? 29.738  -3.475  13.451  1.000 32.176  ? 582 HOH A O     1 ? 
HETATM 2734 O  O     . HOH F 4 .   ? 16.646  28.086  14.904  1.000 34.120  ? 583 HOH A O     1 ? 
HETATM 2735 O  O     . HOH F 4 .   ? 7.802   -12.356 25.772  1.000 37.715  ? 584 HOH A O     1 ? 
HETATM 2736 O  O     . HOH F 4 .   ? 10.063  2.907   -9.606  1.000 55.456  ? 585 HOH A O     1 ? 
HETATM 2737 O  O     . HOH F 4 .   ? 33.214  -0.246  -22.785 1.000 36.312  ? 586 HOH A O     1 ? 
HETATM 2738 O  O     . HOH F 4 .   ? 27.907  -11.275 28.132  1.000 33.464  ? 587 HOH A O     1 ? 
HETATM 2739 O  O     . HOH F 4 .   ? -1.778  11.035  13.559  1.000 34.623  ? 588 HOH A O     1 ? 
HETATM 2740 O  O     . HOH F 4 .   ? 21.072  11.655  -6.259  1.000 33.059  ? 589 HOH A O     1 ? 
HETATM 2741 O  O     . HOH F 4 .   ? 5.845   25.343  -8.049  1.000 36.902  ? 590 HOH A O     1 ? 
HETATM 2742 O  O     . HOH F 4 .   ? 20.532  2.202   9.389   1.000 30.174  ? 591 HOH A O     1 ? 
HETATM 2743 O  O     . HOH F 4 .   ? 9.717   -9.879  -5.948  1.000 39.938  ? 592 HOH A O     1 ? 
HETATM 2744 O  O     . HOH F 4 .   ? -5.162  30.096  8.023   1.000 29.664  ? 593 HOH A O     1 ? 
HETATM 2745 O  O     . HOH F 4 .   ? 28.751  1.125   10.427  1.000 24.540  ? 594 HOH A O     1 ? 
HETATM 2746 O  O     . HOH F 4 .   ? 16.463  -22.944 4.438   1.000 23.031  ? 595 HOH A O     1 ? 
HETATM 2747 O  O     . HOH F 4 .   ? -4.890  7.763   22.355  1.000 26.295  ? 596 HOH A O     1 ? 
HETATM 2748 O  O     . HOH F 4 .   ? 19.435  2.689   4.422   1.000 32.926  ? 597 HOH A O     1 ? 
HETATM 2749 O  O     . HOH F 4 .   ? 25.950  0.785   23.713  1.000 51.461  ? 598 HOH A O     1 ? 
HETATM 2750 O  O     . HOH F 4 .   ? 18.992  4.264   23.844  1.000 39.682  ? 599 HOH A O     1 ? 
HETATM 2751 O  O     . HOH F 4 .   ? 7.782   -10.536 29.208  1.000 42.512  ? 600 HOH A O     1 ? 
HETATM 2752 O  O     . HOH F 4 .   ? 18.745  2.829   7.550   1.000 39.296  ? 601 HOH A O     1 ? 
HETATM 2753 O  O     . HOH F 4 .   ? 11.048  -19.987 24.192  1.000 28.352  ? 602 HOH A O     1 ? 
HETATM 2754 O  O     . HOH F 4 .   ? -3.952  15.758  20.310  1.000 51.453  ? 603 HOH A O     1 ? 
HETATM 2755 O  O     . HOH F 4 .   ? 26.118  7.767   12.963  1.000 32.766  ? 604 HOH A O     1 ? 
HETATM 2756 O  O     . HOH F 4 .   ? -4.973  6.945   19.806  1.000 37.445  ? 605 HOH A O     1 ? 
HETATM 2757 O  O     . HOH F 4 .   ? 9.124   -0.647  -12.501 1.000 44.283  ? 606 HOH A O     1 ? 
HETATM 2758 O  O     . HOH F 4 .   ? 12.616  -17.635 -8.533  1.000 42.280  ? 607 HOH A O     1 ? 
HETATM 2759 O  O     . HOH F 4 .   ? -2.861  1.747   27.141  1.000 31.858  ? 608 HOH A O     1 ? 
HETATM 2760 O  O     . HOH F 4 .   ? 18.981  -2.707  -13.483 1.000 33.171  ? 609 HOH A O     1 ? 
HETATM 2761 O  O     . HOH F 4 .   ? 3.593   -9.988  21.609  1.000 26.346  ? 610 HOH A O     1 ? 
HETATM 2762 O  O     . HOH F 4 .   ? 32.633  -10.966 28.295  1.000 32.298  ? 611 HOH A O     1 ? 
# 
