data_8YQO
# 
_entry.id   8YQO 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YQO         pdb_00008yqo 10.2210/pdb8yqo/pdb 
WWPDB D_1300045920 ?            ?                   
EMDB  EMD-39501    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-26 ? 
2 'EM metadata'     1 0 2025-03-26 ? 
3 'Half map'        1 0 2025-03-26 1 
4 'Half map'        1 0 2025-03-26 2 
5 Image             1 0 2025-03-26 ? 
6 'Primary map'     1 0 2025-03-26 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YQO 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ' 
_pdbx_database_related.db_id          EMD-39501 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chaibing@imm.ac.cn 
_pdbx_contact_author.name_first         Linchao 
_pdbx_contact_author.name_last          Zhou 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5840-0734 
# 
_audit_author.name               'Zhou, L.C.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   0000-0001-5840-0734 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Zhou, L.C.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   0000-0001-5840-0734 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Lanosterol 14-alpha demethylase'                                                                              
52470.188 1 1.14.14.154 ? ? ? 
2 non-polymer syn 'PROTOPORPHYRIN IX CONTAINING FE'                                                                              
616.487   1 ?           ? ? ? 
3 non-polymer syn '(~{E})-2-(2,5-dimethoxyphenyl)-~{N}-[2-(4-hydroxyphenyl)ethyl]-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide' 
449.496   1 ?           ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'LDM,CYPLI,Cytochrome P450 51A1,CYP51A1,Cytochrome P450-14DM,Cytochrome P45014DM,Cytochrome P450LI,Sterol 14-alpha demethylase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAKKTSSKGKLPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAED
VYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHC
LHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDAT
YKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE
TLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRC
IGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSKHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAKKTSSKGKLPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAED
VYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHC
LHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDAT
YKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE
TLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRC
IGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSKHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PROTOPORPHYRIN IX CONTAINING FE'                                                                              HEM   
3 '(~{E})-2-(2,5-dimethoxyphenyl)-~{N}-[2-(4-hydroxyphenyl)ethyl]-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide' A1D61 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   LYS n 
1 4   LYS n 
1 5   THR n 
1 6   SER n 
1 7   SER n 
1 8   LYS n 
1 9   GLY n 
1 10  LYS n 
1 11  LEU n 
1 12  PRO n 
1 13  PRO n 
1 14  TYR n 
1 15  ILE n 
1 16  PHE n 
1 17  SER n 
1 18  PRO n 
1 19  ILE n 
1 20  PRO n 
1 21  PHE n 
1 22  LEU n 
1 23  GLY n 
1 24  HIS n 
1 25  ALA n 
1 26  ILE n 
1 27  ALA n 
1 28  PHE n 
1 29  GLY n 
1 30  LYS n 
1 31  SER n 
1 32  PRO n 
1 33  ILE n 
1 34  GLU n 
1 35  PHE n 
1 36  LEU n 
1 37  GLU n 
1 38  ASN n 
1 39  ALA n 
1 40  TYR n 
1 41  GLU n 
1 42  LYS n 
1 43  TYR n 
1 44  GLY n 
1 45  PRO n 
1 46  VAL n 
1 47  PHE n 
1 48  SER n 
1 49  PHE n 
1 50  THR n 
1 51  MET n 
1 52  VAL n 
1 53  GLY n 
1 54  LYS n 
1 55  THR n 
1 56  PHE n 
1 57  THR n 
1 58  TYR n 
1 59  LEU n 
1 60  LEU n 
1 61  GLY n 
1 62  SER n 
1 63  ASP n 
1 64  ALA n 
1 65  ALA n 
1 66  ALA n 
1 67  LEU n 
1 68  LEU n 
1 69  PHE n 
1 70  ASN n 
1 71  SER n 
1 72  LYS n 
1 73  ASN n 
1 74  GLU n 
1 75  ASP n 
1 76  LEU n 
1 77  ASN n 
1 78  ALA n 
1 79  GLU n 
1 80  ASP n 
1 81  VAL n 
1 82  TYR n 
1 83  SER n 
1 84  ARG n 
1 85  LEU n 
1 86  THR n 
1 87  THR n 
1 88  PRO n 
1 89  VAL n 
1 90  PHE n 
1 91  GLY n 
1 92  LYS n 
1 93  GLY n 
1 94  VAL n 
1 95  ALA n 
1 96  TYR n 
1 97  ASP n 
1 98  VAL n 
1 99  PRO n 
1 100 ASN n 
1 101 PRO n 
1 102 VAL n 
1 103 PHE n 
1 104 LEU n 
1 105 GLU n 
1 106 GLN n 
1 107 LYS n 
1 108 LYS n 
1 109 MET n 
1 110 LEU n 
1 111 LYS n 
1 112 SER n 
1 113 GLY n 
1 114 LEU n 
1 115 ASN n 
1 116 ILE n 
1 117 ALA n 
1 118 HIS n 
1 119 PHE n 
1 120 LYS n 
1 121 GLN n 
1 122 HIS n 
1 123 VAL n 
1 124 SER n 
1 125 ILE n 
1 126 ILE n 
1 127 GLU n 
1 128 LYS n 
1 129 GLU n 
1 130 THR n 
1 131 LYS n 
1 132 GLU n 
1 133 TYR n 
1 134 PHE n 
1 135 GLU n 
1 136 SER n 
1 137 TRP n 
1 138 GLY n 
1 139 GLU n 
1 140 SER n 
1 141 GLY n 
1 142 GLU n 
1 143 LYS n 
1 144 ASN n 
1 145 VAL n 
1 146 PHE n 
1 147 GLU n 
1 148 ALA n 
1 149 LEU n 
1 150 SER n 
1 151 GLU n 
1 152 LEU n 
1 153 ILE n 
1 154 ILE n 
1 155 LEU n 
1 156 THR n 
1 157 ALA n 
1 158 SER n 
1 159 HIS n 
1 160 CYS n 
1 161 LEU n 
1 162 HIS n 
1 163 GLY n 
1 164 LYS n 
1 165 GLU n 
1 166 ILE n 
1 167 ARG n 
1 168 SER n 
1 169 GLN n 
1 170 LEU n 
1 171 ASN n 
1 172 GLU n 
1 173 LYS n 
1 174 VAL n 
1 175 ALA n 
1 176 GLN n 
1 177 LEU n 
1 178 TYR n 
1 179 ALA n 
1 180 ASP n 
1 181 LEU n 
1 182 ASP n 
1 183 GLY n 
1 184 GLY n 
1 185 PHE n 
1 186 SER n 
1 187 HIS n 
1 188 ALA n 
1 189 ALA n 
1 190 TRP n 
1 191 LEU n 
1 192 LEU n 
1 193 PRO n 
1 194 GLY n 
1 195 TRP n 
1 196 LEU n 
1 197 PRO n 
1 198 LEU n 
1 199 PRO n 
1 200 SER n 
1 201 PHE n 
1 202 ARG n 
1 203 ARG n 
1 204 ARG n 
1 205 ASP n 
1 206 ARG n 
1 207 ALA n 
1 208 HIS n 
1 209 ARG n 
1 210 GLU n 
1 211 ILE n 
1 212 LYS n 
1 213 ASP n 
1 214 ILE n 
1 215 PHE n 
1 216 TYR n 
1 217 LYS n 
1 218 ALA n 
1 219 ILE n 
1 220 GLN n 
1 221 LYS n 
1 222 ARG n 
1 223 ARG n 
1 224 GLN n 
1 225 SER n 
1 226 GLN n 
1 227 GLU n 
1 228 LYS n 
1 229 ILE n 
1 230 ASP n 
1 231 ASP n 
1 232 ILE n 
1 233 LEU n 
1 234 GLN n 
1 235 THR n 
1 236 LEU n 
1 237 LEU n 
1 238 ASP n 
1 239 ALA n 
1 240 THR n 
1 241 TYR n 
1 242 LYS n 
1 243 ASP n 
1 244 GLY n 
1 245 ARG n 
1 246 PRO n 
1 247 LEU n 
1 248 THR n 
1 249 ASP n 
1 250 ASP n 
1 251 GLU n 
1 252 VAL n 
1 253 ALA n 
1 254 GLY n 
1 255 MET n 
1 256 LEU n 
1 257 ILE n 
1 258 GLY n 
1 259 LEU n 
1 260 LEU n 
1 261 LEU n 
1 262 ALA n 
1 263 GLY n 
1 264 GLN n 
1 265 HIS n 
1 266 THR n 
1 267 SER n 
1 268 SER n 
1 269 THR n 
1 270 THR n 
1 271 SER n 
1 272 ALA n 
1 273 TRP n 
1 274 MET n 
1 275 GLY n 
1 276 PHE n 
1 277 PHE n 
1 278 LEU n 
1 279 ALA n 
1 280 ARG n 
1 281 ASP n 
1 282 LYS n 
1 283 THR n 
1 284 LEU n 
1 285 GLN n 
1 286 LYS n 
1 287 LYS n 
1 288 CYS n 
1 289 TYR n 
1 290 LEU n 
1 291 GLU n 
1 292 GLN n 
1 293 LYS n 
1 294 THR n 
1 295 VAL n 
1 296 CYS n 
1 297 GLY n 
1 298 GLU n 
1 299 ASN n 
1 300 LEU n 
1 301 PRO n 
1 302 PRO n 
1 303 LEU n 
1 304 THR n 
1 305 TYR n 
1 306 ASP n 
1 307 GLN n 
1 308 LEU n 
1 309 LYS n 
1 310 ASP n 
1 311 LEU n 
1 312 ASN n 
1 313 LEU n 
1 314 LEU n 
1 315 ASP n 
1 316 ARG n 
1 317 CYS n 
1 318 ILE n 
1 319 LYS n 
1 320 GLU n 
1 321 THR n 
1 322 LEU n 
1 323 ARG n 
1 324 LEU n 
1 325 ARG n 
1 326 PRO n 
1 327 PRO n 
1 328 ILE n 
1 329 MET n 
1 330 ILE n 
1 331 MET n 
1 332 MET n 
1 333 ARG n 
1 334 MET n 
1 335 ALA n 
1 336 ARG n 
1 337 THR n 
1 338 PRO n 
1 339 GLN n 
1 340 THR n 
1 341 VAL n 
1 342 ALA n 
1 343 GLY n 
1 344 TYR n 
1 345 THR n 
1 346 ILE n 
1 347 PRO n 
1 348 PRO n 
1 349 GLY n 
1 350 HIS n 
1 351 GLN n 
1 352 VAL n 
1 353 CYS n 
1 354 VAL n 
1 355 SER n 
1 356 PRO n 
1 357 THR n 
1 358 VAL n 
1 359 ASN n 
1 360 GLN n 
1 361 ARG n 
1 362 LEU n 
1 363 LYS n 
1 364 ASP n 
1 365 SER n 
1 366 TRP n 
1 367 VAL n 
1 368 GLU n 
1 369 ARG n 
1 370 LEU n 
1 371 ASP n 
1 372 PHE n 
1 373 ASN n 
1 374 PRO n 
1 375 ASP n 
1 376 ARG n 
1 377 TYR n 
1 378 LEU n 
1 379 GLN n 
1 380 ASP n 
1 381 ASN n 
1 382 PRO n 
1 383 ALA n 
1 384 SER n 
1 385 GLY n 
1 386 GLU n 
1 387 LYS n 
1 388 PHE n 
1 389 ALA n 
1 390 TYR n 
1 391 VAL n 
1 392 PRO n 
1 393 PHE n 
1 394 GLY n 
1 395 ALA n 
1 396 GLY n 
1 397 ARG n 
1 398 HIS n 
1 399 ARG n 
1 400 CYS n 
1 401 ILE n 
1 402 GLY n 
1 403 GLU n 
1 404 ASN n 
1 405 PHE n 
1 406 ALA n 
1 407 TYR n 
1 408 VAL n 
1 409 GLN n 
1 410 ILE n 
1 411 LYS n 
1 412 THR n 
1 413 ILE n 
1 414 TRP n 
1 415 SER n 
1 416 THR n 
1 417 MET n 
1 418 LEU n 
1 419 ARG n 
1 420 LEU n 
1 421 TYR n 
1 422 GLU n 
1 423 PHE n 
1 424 ASP n 
1 425 LEU n 
1 426 ILE n 
1 427 ASP n 
1 428 GLY n 
1 429 TYR n 
1 430 PHE n 
1 431 PRO n 
1 432 THR n 
1 433 VAL n 
1 434 ASN n 
1 435 TYR n 
1 436 THR n 
1 437 THR n 
1 438 MET n 
1 439 ILE n 
1 440 HIS n 
1 441 THR n 
1 442 PRO n 
1 443 GLU n 
1 444 ASN n 
1 445 PRO n 
1 446 VAL n 
1 447 ILE n 
1 448 ARG n 
1 449 TYR n 
1 450 LYS n 
1 451 ARG n 
1 452 ARG n 
1 453 SER n 
1 454 LYS n 
1 455 HIS n 
1 456 HIS n 
1 457 HIS n 
1 458 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   458 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'CYP51A1, CYP51' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D61 non-polymer         . 
'(~{E})-2-(2,5-dimethoxyphenyl)-~{N}-[2-(4-hydroxyphenyl)ethyl]-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide' ?    'C26 H27 N O6' 
449.496 
ALA   'L-peptide linking' y ALANINE ?    'C3 H7 N O2'       89.093  
ARG   'L-peptide linking' y ARGININE ?    'C6 H15 N4 O2 1'   175.209 
ASN   'L-peptide linking' y ASPARAGINE ?    'C4 H8 N2 O3'      132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?    'C4 H7 N O4'       133.103 
CYS   'L-peptide linking' y CYSTEINE ?    'C3 H7 N O2 S'     121.158 
GLN   'L-peptide linking' y GLUTAMINE ?    'C5 H10 N2 O3'     146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?    'C5 H9 N O4'       147.129 
GLY   'peptide linking'   y GLYCINE ?    'C2 H5 N O2'       75.067  
HEM   non-polymer         . 'PROTOPORPHYRIN IX CONTAINING FE' HEME 'C34 H32 Fe N4 O4' 616.487 
HIS   'L-peptide linking' y HISTIDINE ?    'C6 H10 N3 O2 1'   156.162 
ILE   'L-peptide linking' y ISOLEUCINE ?    'C6 H13 N O2'      131.173 
LEU   'L-peptide linking' y LEUCINE ?    'C6 H13 N O2'      131.173 
LYS   'L-peptide linking' y LYSINE ?    'C6 H15 N2 O2 1'   147.195 
MET   'L-peptide linking' y METHIONINE ?    'C5 H11 N O2 S'    149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?    'C9 H11 N O2'      165.189 
PRO   'L-peptide linking' y PROLINE ?    'C5 H9 N O2'       115.130 
SER   'L-peptide linking' y SERINE ?    'C3 H7 N O3'       105.093 
THR   'L-peptide linking' y THREONINE ?    'C4 H9 N O3'       119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?    'C11 H12 N2 O2'    204.225 
TYR   'L-peptide linking' y TYROSINE ?    'C9 H11 N O3'      181.189 
VAL   'L-peptide linking' y VALINE ?    'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   50  ?   ?   ?   A . n 
A 1 2   ALA 2   51  ?   ?   ?   A . n 
A 1 3   LYS 3   52  ?   ?   ?   A . n 
A 1 4   LYS 4   53  ?   ?   ?   A . n 
A 1 5   THR 5   54  ?   ?   ?   A . n 
A 1 6   SER 6   55  ?   ?   ?   A . n 
A 1 7   SER 7   56  ?   ?   ?   A . n 
A 1 8   LYS 8   57  ?   ?   ?   A . n 
A 1 9   GLY 9   58  58  GLY GLY A . n 
A 1 10  LYS 10  59  59  LYS LYS A . n 
A 1 11  LEU 11  60  60  LEU LEU A . n 
A 1 12  PRO 12  61  61  PRO PRO A . n 
A 1 13  PRO 13  62  62  PRO PRO A . n 
A 1 14  TYR 14  63  63  TYR TYR A . n 
A 1 15  ILE 15  64  64  ILE ILE A . n 
A 1 16  PHE 16  65  65  PHE PHE A . n 
A 1 17  SER 17  66  66  SER SER A . n 
A 1 18  PRO 18  67  67  PRO PRO A . n 
A 1 19  ILE 19  68  68  ILE ILE A . n 
A 1 20  PRO 20  69  69  PRO PRO A . n 
A 1 21  PHE 21  70  70  PHE PHE A . n 
A 1 22  LEU 22  71  71  LEU LEU A . n 
A 1 23  GLY 23  72  72  GLY GLY A . n 
A 1 24  HIS 24  73  73  HIS HIS A . n 
A 1 25  ALA 25  74  74  ALA ALA A . n 
A 1 26  ILE 26  75  75  ILE ILE A . n 
A 1 27  ALA 27  76  76  ALA ALA A . n 
A 1 28  PHE 28  77  77  PHE PHE A . n 
A 1 29  GLY 29  78  78  GLY GLY A . n 
A 1 30  LYS 30  79  79  LYS LYS A . n 
A 1 31  SER 31  80  80  SER SER A . n 
A 1 32  PRO 32  81  81  PRO PRO A . n 
A 1 33  ILE 33  82  82  ILE ILE A . n 
A 1 34  GLU 34  83  83  GLU GLU A . n 
A 1 35  PHE 35  84  84  PHE PHE A . n 
A 1 36  LEU 36  85  85  LEU LEU A . n 
A 1 37  GLU 37  86  86  GLU GLU A . n 
A 1 38  ASN 38  87  87  ASN ASN A . n 
A 1 39  ALA 39  88  88  ALA ALA A . n 
A 1 40  TYR 40  89  89  TYR TYR A . n 
A 1 41  GLU 41  90  90  GLU GLU A . n 
A 1 42  LYS 42  91  91  LYS LYS A . n 
A 1 43  TYR 43  92  92  TYR TYR A . n 
A 1 44  GLY 44  93  93  GLY GLY A . n 
A 1 45  PRO 45  94  94  PRO PRO A . n 
A 1 46  VAL 46  95  95  VAL VAL A . n 
A 1 47  PHE 47  96  96  PHE PHE A . n 
A 1 48  SER 48  97  97  SER SER A . n 
A 1 49  PHE 49  98  98  PHE PHE A . n 
A 1 50  THR 50  99  99  THR THR A . n 
A 1 51  MET 51  100 100 MET MET A . n 
A 1 52  VAL 52  101 101 VAL VAL A . n 
A 1 53  GLY 53  102 102 GLY GLY A . n 
A 1 54  LYS 54  103 103 LYS LYS A . n 
A 1 55  THR 55  104 104 THR THR A . n 
A 1 56  PHE 56  105 105 PHE PHE A . n 
A 1 57  THR 57  106 106 THR THR A . n 
A 1 58  TYR 58  107 107 TYR TYR A . n 
A 1 59  LEU 59  108 108 LEU LEU A . n 
A 1 60  LEU 60  109 109 LEU LEU A . n 
A 1 61  GLY 61  110 110 GLY GLY A . n 
A 1 62  SER 62  111 111 SER SER A . n 
A 1 63  ASP 63  112 112 ASP ASP A . n 
A 1 64  ALA 64  113 113 ALA ALA A . n 
A 1 65  ALA 65  114 114 ALA ALA A . n 
A 1 66  ALA 66  115 115 ALA ALA A . n 
A 1 67  LEU 67  116 116 LEU LEU A . n 
A 1 68  LEU 68  117 117 LEU LEU A . n 
A 1 69  PHE 69  118 118 PHE PHE A . n 
A 1 70  ASN 70  119 119 ASN ASN A . n 
A 1 71  SER 71  120 120 SER SER A . n 
A 1 72  LYS 72  121 121 LYS LYS A . n 
A 1 73  ASN 73  122 122 ASN ASN A . n 
A 1 74  GLU 74  123 123 GLU GLU A . n 
A 1 75  ASP 75  124 124 ASP ASP A . n 
A 1 76  LEU 76  125 125 LEU LEU A . n 
A 1 77  ASN 77  126 126 ASN ASN A . n 
A 1 78  ALA 78  127 127 ALA ALA A . n 
A 1 79  GLU 79  128 128 GLU GLU A . n 
A 1 80  ASP 80  129 129 ASP ASP A . n 
A 1 81  VAL 81  130 130 VAL VAL A . n 
A 1 82  TYR 82  131 131 TYR TYR A . n 
A 1 83  SER 83  132 132 SER SER A . n 
A 1 84  ARG 84  133 133 ARG ARG A . n 
A 1 85  LEU 85  134 134 LEU LEU A . n 
A 1 86  THR 86  135 135 THR THR A . n 
A 1 87  THR 87  136 136 THR THR A . n 
A 1 88  PRO 88  137 137 PRO PRO A . n 
A 1 89  VAL 89  138 138 VAL VAL A . n 
A 1 90  PHE 90  139 139 PHE PHE A . n 
A 1 91  GLY 91  140 140 GLY GLY A . n 
A 1 92  LYS 92  141 141 LYS LYS A . n 
A 1 93  GLY 93  142 142 GLY GLY A . n 
A 1 94  VAL 94  143 143 VAL VAL A . n 
A 1 95  ALA 95  144 144 ALA ALA A . n 
A 1 96  TYR 96  145 145 TYR TYR A . n 
A 1 97  ASP 97  146 146 ASP ASP A . n 
A 1 98  VAL 98  147 147 VAL VAL A . n 
A 1 99  PRO 99  148 148 PRO PRO A . n 
A 1 100 ASN 100 149 149 ASN ASN A . n 
A 1 101 PRO 101 150 150 PRO PRO A . n 
A 1 102 VAL 102 151 151 VAL VAL A . n 
A 1 103 PHE 103 152 152 PHE PHE A . n 
A 1 104 LEU 104 153 153 LEU LEU A . n 
A 1 105 GLU 105 154 154 GLU GLU A . n 
A 1 106 GLN 106 155 155 GLN GLN A . n 
A 1 107 LYS 107 156 156 LYS LYS A . n 
A 1 108 LYS 108 157 157 LYS LYS A . n 
A 1 109 MET 109 158 158 MET MET A . n 
A 1 110 LEU 110 159 159 LEU LEU A . n 
A 1 111 LYS 111 160 160 LYS LYS A . n 
A 1 112 SER 112 161 161 SER SER A . n 
A 1 113 GLY 113 162 162 GLY GLY A . n 
A 1 114 LEU 114 163 163 LEU LEU A . n 
A 1 115 ASN 115 164 164 ASN ASN A . n 
A 1 116 ILE 116 165 165 ILE ILE A . n 
A 1 117 ALA 117 166 166 ALA ALA A . n 
A 1 118 HIS 118 167 167 HIS HIS A . n 
A 1 119 PHE 119 168 168 PHE PHE A . n 
A 1 120 LYS 120 169 169 LYS LYS A . n 
A 1 121 GLN 121 170 170 GLN GLN A . n 
A 1 122 HIS 122 171 171 HIS HIS A . n 
A 1 123 VAL 123 172 172 VAL VAL A . n 
A 1 124 SER 124 173 173 SER SER A . n 
A 1 125 ILE 125 174 174 ILE ILE A . n 
A 1 126 ILE 126 175 175 ILE ILE A . n 
A 1 127 GLU 127 176 176 GLU GLU A . n 
A 1 128 LYS 128 177 177 LYS LYS A . n 
A 1 129 GLU 129 178 178 GLU GLU A . n 
A 1 130 THR 130 179 179 THR THR A . n 
A 1 131 LYS 131 180 180 LYS LYS A . n 
A 1 132 GLU 132 181 181 GLU GLU A . n 
A 1 133 TYR 133 182 182 TYR TYR A . n 
A 1 134 PHE 134 183 183 PHE PHE A . n 
A 1 135 GLU 135 184 184 GLU GLU A . n 
A 1 136 SER 136 185 185 SER SER A . n 
A 1 137 TRP 137 186 186 TRP TRP A . n 
A 1 138 GLY 138 187 187 GLY GLY A . n 
A 1 139 GLU 139 188 188 GLU GLU A . n 
A 1 140 SER 140 189 189 SER SER A . n 
A 1 141 GLY 141 190 190 GLY GLY A . n 
A 1 142 GLU 142 191 191 GLU GLU A . n 
A 1 143 LYS 143 192 192 LYS LYS A . n 
A 1 144 ASN 144 193 193 ASN ASN A . n 
A 1 145 VAL 145 194 194 VAL VAL A . n 
A 1 146 PHE 146 195 195 PHE PHE A . n 
A 1 147 GLU 147 196 196 GLU GLU A . n 
A 1 148 ALA 148 197 197 ALA ALA A . n 
A 1 149 LEU 149 198 198 LEU LEU A . n 
A 1 150 SER 150 199 199 SER SER A . n 
A 1 151 GLU 151 200 200 GLU GLU A . n 
A 1 152 LEU 152 201 201 LEU LEU A . n 
A 1 153 ILE 153 202 202 ILE ILE A . n 
A 1 154 ILE 154 203 203 ILE ILE A . n 
A 1 155 LEU 155 204 204 LEU LEU A . n 
A 1 156 THR 156 205 205 THR THR A . n 
A 1 157 ALA 157 206 206 ALA ALA A . n 
A 1 158 SER 158 207 207 SER SER A . n 
A 1 159 HIS 159 208 208 HIS HIS A . n 
A 1 160 CYS 160 209 209 CYS CYS A . n 
A 1 161 LEU 161 210 210 LEU LEU A . n 
A 1 162 HIS 162 211 211 HIS HIS A . n 
A 1 163 GLY 163 212 212 GLY GLY A . n 
A 1 164 LYS 164 213 213 LYS LYS A . n 
A 1 165 GLU 165 214 214 GLU GLU A . n 
A 1 166 ILE 166 215 215 ILE ILE A . n 
A 1 167 ARG 167 216 216 ARG ARG A . n 
A 1 168 SER 168 217 217 SER SER A . n 
A 1 169 GLN 169 218 218 GLN GLN A . n 
A 1 170 LEU 170 219 219 LEU LEU A . n 
A 1 171 ASN 171 220 220 ASN ASN A . n 
A 1 172 GLU 172 221 221 GLU GLU A . n 
A 1 173 LYS 173 222 222 LYS LYS A . n 
A 1 174 VAL 174 223 223 VAL VAL A . n 
A 1 175 ALA 175 224 224 ALA ALA A . n 
A 1 176 GLN 176 225 225 GLN GLN A . n 
A 1 177 LEU 177 226 226 LEU LEU A . n 
A 1 178 TYR 178 227 227 TYR TYR A . n 
A 1 179 ALA 179 228 228 ALA ALA A . n 
A 1 180 ASP 180 229 229 ASP ASP A . n 
A 1 181 LEU 181 230 230 LEU LEU A . n 
A 1 182 ASP 182 231 231 ASP ASP A . n 
A 1 183 GLY 183 232 232 GLY GLY A . n 
A 1 184 GLY 184 233 233 GLY GLY A . n 
A 1 185 PHE 185 234 234 PHE PHE A . n 
A 1 186 SER 186 235 235 SER SER A . n 
A 1 187 HIS 187 236 236 HIS HIS A . n 
A 1 188 ALA 188 237 237 ALA ALA A . n 
A 1 189 ALA 189 238 238 ALA ALA A . n 
A 1 190 TRP 190 239 239 TRP TRP A . n 
A 1 191 LEU 191 240 240 LEU LEU A . n 
A 1 192 LEU 192 241 241 LEU LEU A . n 
A 1 193 PRO 193 242 242 PRO PRO A . n 
A 1 194 GLY 194 243 243 GLY GLY A . n 
A 1 195 TRP 195 244 244 TRP TRP A . n 
A 1 196 LEU 196 245 245 LEU LEU A . n 
A 1 197 PRO 197 246 246 PRO PRO A . n 
A 1 198 LEU 198 247 247 LEU LEU A . n 
A 1 199 PRO 199 248 248 PRO PRO A . n 
A 1 200 SER 200 249 249 SER SER A . n 
A 1 201 PHE 201 250 250 PHE PHE A . n 
A 1 202 ARG 202 251 251 ARG ARG A . n 
A 1 203 ARG 203 252 252 ARG ARG A . n 
A 1 204 ARG 204 253 253 ARG ARG A . n 
A 1 205 ASP 205 254 254 ASP ASP A . n 
A 1 206 ARG 206 255 255 ARG ARG A . n 
A 1 207 ALA 207 256 256 ALA ALA A . n 
A 1 208 HIS 208 257 257 HIS HIS A . n 
A 1 209 ARG 209 258 258 ARG ARG A . n 
A 1 210 GLU 210 259 259 GLU GLU A . n 
A 1 211 ILE 211 260 260 ILE ILE A . n 
A 1 212 LYS 212 261 261 LYS LYS A . n 
A 1 213 ASP 213 262 262 ASP ASP A . n 
A 1 214 ILE 214 263 263 ILE ILE A . n 
A 1 215 PHE 215 264 264 PHE PHE A . n 
A 1 216 TYR 216 265 265 TYR TYR A . n 
A 1 217 LYS 217 266 266 LYS LYS A . n 
A 1 218 ALA 218 267 267 ALA ALA A . n 
A 1 219 ILE 219 268 268 ILE ILE A . n 
A 1 220 GLN 220 269 269 GLN GLN A . n 
A 1 221 LYS 221 270 270 LYS LYS A . n 
A 1 222 ARG 222 271 271 ARG ARG A . n 
A 1 223 ARG 223 272 272 ARG ARG A . n 
A 1 224 GLN 224 273 273 GLN GLN A . n 
A 1 225 SER 225 274 274 SER SER A . n 
A 1 226 GLN 226 275 275 GLN GLN A . n 
A 1 227 GLU 227 276 276 GLU GLU A . n 
A 1 228 LYS 228 277 277 LYS LYS A . n 
A 1 229 ILE 229 278 278 ILE ILE A . n 
A 1 230 ASP 230 279 279 ASP ASP A . n 
A 1 231 ASP 231 280 280 ASP ASP A . n 
A 1 232 ILE 232 281 281 ILE ILE A . n 
A 1 233 LEU 233 282 282 LEU LEU A . n 
A 1 234 GLN 234 283 283 GLN GLN A . n 
A 1 235 THR 235 284 284 THR THR A . n 
A 1 236 LEU 236 285 285 LEU LEU A . n 
A 1 237 LEU 237 286 286 LEU LEU A . n 
A 1 238 ASP 238 287 287 ASP ASP A . n 
A 1 239 ALA 239 288 288 ALA ALA A . n 
A 1 240 THR 240 289 289 THR THR A . n 
A 1 241 TYR 241 290 290 TYR TYR A . n 
A 1 242 LYS 242 291 291 LYS LYS A . n 
A 1 243 ASP 243 292 292 ASP ASP A . n 
A 1 244 GLY 244 293 293 GLY GLY A . n 
A 1 245 ARG 245 294 294 ARG ARG A . n 
A 1 246 PRO 246 295 295 PRO PRO A . n 
A 1 247 LEU 247 296 296 LEU LEU A . n 
A 1 248 THR 248 297 297 THR THR A . n 
A 1 249 ASP 249 298 298 ASP ASP A . n 
A 1 250 ASP 250 299 299 ASP ASP A . n 
A 1 251 GLU 251 300 300 GLU GLU A . n 
A 1 252 VAL 252 301 301 VAL VAL A . n 
A 1 253 ALA 253 302 302 ALA ALA A . n 
A 1 254 GLY 254 303 303 GLY GLY A . n 
A 1 255 MET 255 304 304 MET MET A . n 
A 1 256 LEU 256 305 305 LEU LEU A . n 
A 1 257 ILE 257 306 306 ILE ILE A . n 
A 1 258 GLY 258 307 307 GLY GLY A . n 
A 1 259 LEU 259 308 308 LEU LEU A . n 
A 1 260 LEU 260 309 309 LEU LEU A . n 
A 1 261 LEU 261 310 310 LEU LEU A . n 
A 1 262 ALA 262 311 311 ALA ALA A . n 
A 1 263 GLY 263 312 312 GLY GLY A . n 
A 1 264 GLN 264 313 313 GLN GLN A . n 
A 1 265 HIS 265 314 314 HIS HIS A . n 
A 1 266 THR 266 315 315 THR THR A . n 
A 1 267 SER 267 316 316 SER SER A . n 
A 1 268 SER 268 317 317 SER SER A . n 
A 1 269 THR 269 318 318 THR THR A . n 
A 1 270 THR 270 319 319 THR THR A . n 
A 1 271 SER 271 320 320 SER SER A . n 
A 1 272 ALA 272 321 321 ALA ALA A . n 
A 1 273 TRP 273 322 322 TRP TRP A . n 
A 1 274 MET 274 323 323 MET MET A . n 
A 1 275 GLY 275 324 324 GLY GLY A . n 
A 1 276 PHE 276 325 325 PHE PHE A . n 
A 1 277 PHE 277 326 326 PHE PHE A . n 
A 1 278 LEU 278 327 327 LEU LEU A . n 
A 1 279 ALA 279 328 328 ALA ALA A . n 
A 1 280 ARG 280 329 329 ARG ARG A . n 
A 1 281 ASP 281 330 330 ASP ASP A . n 
A 1 282 LYS 282 331 331 LYS LYS A . n 
A 1 283 THR 283 332 332 THR THR A . n 
A 1 284 LEU 284 333 333 LEU LEU A . n 
A 1 285 GLN 285 334 334 GLN GLN A . n 
A 1 286 LYS 286 335 335 LYS LYS A . n 
A 1 287 LYS 287 336 336 LYS LYS A . n 
A 1 288 CYS 288 337 337 CYS CYS A . n 
A 1 289 TYR 289 338 338 TYR TYR A . n 
A 1 290 LEU 290 339 339 LEU LEU A . n 
A 1 291 GLU 291 340 340 GLU GLU A . n 
A 1 292 GLN 292 341 341 GLN GLN A . n 
A 1 293 LYS 293 342 342 LYS LYS A . n 
A 1 294 THR 294 343 343 THR THR A . n 
A 1 295 VAL 295 344 344 VAL VAL A . n 
A 1 296 CYS 296 345 345 CYS CYS A . n 
A 1 297 GLY 297 346 346 GLY GLY A . n 
A 1 298 GLU 298 347 347 GLU GLU A . n 
A 1 299 ASN 299 348 348 ASN ASN A . n 
A 1 300 LEU 300 349 349 LEU LEU A . n 
A 1 301 PRO 301 350 350 PRO PRO A . n 
A 1 302 PRO 302 351 351 PRO PRO A . n 
A 1 303 LEU 303 352 352 LEU LEU A . n 
A 1 304 THR 304 353 353 THR THR A . n 
A 1 305 TYR 305 354 354 TYR TYR A . n 
A 1 306 ASP 306 355 355 ASP ASP A . n 
A 1 307 GLN 307 356 356 GLN GLN A . n 
A 1 308 LEU 308 357 357 LEU LEU A . n 
A 1 309 LYS 309 358 358 LYS LYS A . n 
A 1 310 ASP 310 359 359 ASP ASP A . n 
A 1 311 LEU 311 360 360 LEU LEU A . n 
A 1 312 ASN 312 361 361 ASN ASN A . n 
A 1 313 LEU 313 362 362 LEU LEU A . n 
A 1 314 LEU 314 363 363 LEU LEU A . n 
A 1 315 ASP 315 364 364 ASP ASP A . n 
A 1 316 ARG 316 365 365 ARG ARG A . n 
A 1 317 CYS 317 366 366 CYS CYS A . n 
A 1 318 ILE 318 367 367 ILE ILE A . n 
A 1 319 LYS 319 368 368 LYS LYS A . n 
A 1 320 GLU 320 369 369 GLU GLU A . n 
A 1 321 THR 321 370 370 THR THR A . n 
A 1 322 LEU 322 371 371 LEU LEU A . n 
A 1 323 ARG 323 372 372 ARG ARG A . n 
A 1 324 LEU 324 373 373 LEU LEU A . n 
A 1 325 ARG 325 374 374 ARG ARG A . n 
A 1 326 PRO 326 375 375 PRO PRO A . n 
A 1 327 PRO 327 376 376 PRO PRO A . n 
A 1 328 ILE 328 377 377 ILE ILE A . n 
A 1 329 MET 329 378 378 MET MET A . n 
A 1 330 ILE 330 379 379 ILE ILE A . n 
A 1 331 MET 331 380 380 MET MET A . n 
A 1 332 MET 332 381 381 MET MET A . n 
A 1 333 ARG 333 382 382 ARG ARG A . n 
A 1 334 MET 334 383 383 MET MET A . n 
A 1 335 ALA 335 384 384 ALA ALA A . n 
A 1 336 ARG 336 385 385 ARG ARG A . n 
A 1 337 THR 337 386 386 THR THR A . n 
A 1 338 PRO 338 387 387 PRO PRO A . n 
A 1 339 GLN 339 388 388 GLN GLN A . n 
A 1 340 THR 340 389 389 THR THR A . n 
A 1 341 VAL 341 390 390 VAL VAL A . n 
A 1 342 ALA 342 391 391 ALA ALA A . n 
A 1 343 GLY 343 392 392 GLY GLY A . n 
A 1 344 TYR 344 393 393 TYR TYR A . n 
A 1 345 THR 345 394 394 THR THR A . n 
A 1 346 ILE 346 395 395 ILE ILE A . n 
A 1 347 PRO 347 396 396 PRO PRO A . n 
A 1 348 PRO 348 397 397 PRO PRO A . n 
A 1 349 GLY 349 398 398 GLY GLY A . n 
A 1 350 HIS 350 399 399 HIS HIS A . n 
A 1 351 GLN 351 400 400 GLN GLN A . n 
A 1 352 VAL 352 401 401 VAL VAL A . n 
A 1 353 CYS 353 402 402 CYS CYS A . n 
A 1 354 VAL 354 403 403 VAL VAL A . n 
A 1 355 SER 355 404 404 SER SER A . n 
A 1 356 PRO 356 405 405 PRO PRO A . n 
A 1 357 THR 357 406 406 THR THR A . n 
A 1 358 VAL 358 407 407 VAL VAL A . n 
A 1 359 ASN 359 408 408 ASN ASN A . n 
A 1 360 GLN 360 409 409 GLN GLN A . n 
A 1 361 ARG 361 410 410 ARG ARG A . n 
A 1 362 LEU 362 411 411 LEU LEU A . n 
A 1 363 LYS 363 412 412 LYS LYS A . n 
A 1 364 ASP 364 413 413 ASP ASP A . n 
A 1 365 SER 365 414 414 SER SER A . n 
A 1 366 TRP 366 415 415 TRP TRP A . n 
A 1 367 VAL 367 416 416 VAL VAL A . n 
A 1 368 GLU 368 417 417 GLU GLU A . n 
A 1 369 ARG 369 418 418 ARG ARG A . n 
A 1 370 LEU 370 419 419 LEU LEU A . n 
A 1 371 ASP 371 420 420 ASP ASP A . n 
A 1 372 PHE 372 421 421 PHE PHE A . n 
A 1 373 ASN 373 422 422 ASN ASN A . n 
A 1 374 PRO 374 423 423 PRO PRO A . n 
A 1 375 ASP 375 424 424 ASP ASP A . n 
A 1 376 ARG 376 425 425 ARG ARG A . n 
A 1 377 TYR 377 426 426 TYR TYR A . n 
A 1 378 LEU 378 427 427 LEU LEU A . n 
A 1 379 GLN 379 428 428 GLN GLN A . n 
A 1 380 ASP 380 429 429 ASP ASP A . n 
A 1 381 ASN 381 430 430 ASN ASN A . n 
A 1 382 PRO 382 431 431 PRO PRO A . n 
A 1 383 ALA 383 432 432 ALA ALA A . n 
A 1 384 SER 384 433 433 SER SER A . n 
A 1 385 GLY 385 434 434 GLY GLY A . n 
A 1 386 GLU 386 435 435 GLU GLU A . n 
A 1 387 LYS 387 436 436 LYS LYS A . n 
A 1 388 PHE 388 437 437 PHE PHE A . n 
A 1 389 ALA 389 438 438 ALA ALA A . n 
A 1 390 TYR 390 439 439 TYR TYR A . n 
A 1 391 VAL 391 440 440 VAL VAL A . n 
A 1 392 PRO 392 441 441 PRO PRO A . n 
A 1 393 PHE 393 442 442 PHE PHE A . n 
A 1 394 GLY 394 443 443 GLY GLY A . n 
A 1 395 ALA 395 444 444 ALA ALA A . n 
A 1 396 GLY 396 445 445 GLY GLY A . n 
A 1 397 ARG 397 446 446 ARG ARG A . n 
A 1 398 HIS 398 447 447 HIS HIS A . n 
A 1 399 ARG 399 448 448 ARG ARG A . n 
A 1 400 CYS 400 449 449 CYS CYS A . n 
A 1 401 ILE 401 450 450 ILE ILE A . n 
A 1 402 GLY 402 451 451 GLY GLY A . n 
A 1 403 GLU 403 452 452 GLU GLU A . n 
A 1 404 ASN 404 453 453 ASN ASN A . n 
A 1 405 PHE 405 454 454 PHE PHE A . n 
A 1 406 ALA 406 455 455 ALA ALA A . n 
A 1 407 TYR 407 456 456 TYR TYR A . n 
A 1 408 VAL 408 457 457 VAL VAL A . n 
A 1 409 GLN 409 458 458 GLN GLN A . n 
A 1 410 ILE 410 459 459 ILE ILE A . n 
A 1 411 LYS 411 460 460 LYS LYS A . n 
A 1 412 THR 412 461 461 THR THR A . n 
A 1 413 ILE 413 462 462 ILE ILE A . n 
A 1 414 TRP 414 463 463 TRP TRP A . n 
A 1 415 SER 415 464 464 SER SER A . n 
A 1 416 THR 416 465 465 THR THR A . n 
A 1 417 MET 417 466 466 MET MET A . n 
A 1 418 LEU 418 467 467 LEU LEU A . n 
A 1 419 ARG 419 468 468 ARG ARG A . n 
A 1 420 LEU 420 469 469 LEU LEU A . n 
A 1 421 TYR 421 470 470 TYR TYR A . n 
A 1 422 GLU 422 471 471 GLU GLU A . n 
A 1 423 PHE 423 472 472 PHE PHE A . n 
A 1 424 ASP 424 473 473 ASP ASP A . n 
A 1 425 LEU 425 474 474 LEU LEU A . n 
A 1 426 ILE 426 475 475 ILE ILE A . n 
A 1 427 ASP 427 476 476 ASP ASP A . n 
A 1 428 GLY 428 477 477 GLY GLY A . n 
A 1 429 TYR 429 478 478 TYR TYR A . n 
A 1 430 PHE 430 479 479 PHE PHE A . n 
A 1 431 PRO 431 480 480 PRO PRO A . n 
A 1 432 THR 432 481 481 THR THR A . n 
A 1 433 VAL 433 482 482 VAL VAL A . n 
A 1 434 ASN 434 483 483 ASN ASN A . n 
A 1 435 TYR 435 484 484 TYR TYR A . n 
A 1 436 THR 436 485 485 THR THR A . n 
A 1 437 THR 437 486 486 THR THR A . n 
A 1 438 MET 438 487 487 MET MET A . n 
A 1 439 ILE 439 488 488 ILE ILE A . n 
A 1 440 HIS 440 489 489 HIS HIS A . n 
A 1 441 THR 441 490 490 THR THR A . n 
A 1 442 PRO 442 491 491 PRO PRO A . n 
A 1 443 GLU 443 492 492 GLU GLU A . n 
A 1 444 ASN 444 493 493 ASN ASN A . n 
A 1 445 PRO 445 494 494 PRO PRO A . n 
A 1 446 VAL 446 495 495 VAL VAL A . n 
A 1 447 ILE 447 496 496 ILE ILE A . n 
A 1 448 ARG 448 497 497 ARG ARG A . n 
A 1 449 TYR 449 498 498 TYR TYR A . n 
A 1 450 LYS 450 499 499 LYS LYS A . n 
A 1 451 ARG 451 500 500 ARG ARG A . n 
A 1 452 ARG 452 501 501 ARG ARG A . n 
A 1 453 SER 453 502 502 SER SER A . n 
A 1 454 LYS 454 503 ?   ?   ?   A . n 
A 1 455 HIS 455 504 ?   ?   ?   A . n 
A 1 456 HIS 456 505 ?   ?   ?   A . n 
A 1 457 HIS 457 506 ?   ?   ?   A . n 
A 1 458 HIS 458 507 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 A1D61 ? ? A1D61 ? ? 'SUBJECT OF INVESTIGATION' ? 
2 HEM   ? ? HEM   ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HEM   1 601 601 HEM   HEM A . 
C 3 A1D61 1 602 602 A1D61 P51 A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YQO 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YQO 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YQO 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8YQO 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 3766 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.808 ? 5115 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 7.618 ? 504  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.040 ? 539  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 652  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8YQO 
_struct.title                        'Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YQO 
_struct_keywords.text            
;CYP51A1;FLZ;cryo-EM;Parkinson's disease;Alzheimer's disease, PROTEIN BINDING
;
_struct_keywords.pdbx_keywords   'PROTEIN BINDING' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CP51A_HUMAN 
_struct_ref.pdbx_db_accession          Q16850 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG
KGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLN
EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE
VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM
MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK
TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
;
_struct_ref.pdbx_align_begin           67 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YQO 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 12 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 454 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q16850 
_struct_ref_seq.db_align_beg                  67 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  509 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       61 
_struct_ref_seq.pdbx_auth_seq_align_end       503 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YQO MET A 1   ? UNP Q16850 ? ? 'initiating methionine' 50  1  
1 8YQO ALA A 2   ? UNP Q16850 ? ? 'expression tag'        51  2  
1 8YQO LYS A 3   ? UNP Q16850 ? ? 'expression tag'        52  3  
1 8YQO LYS A 4   ? UNP Q16850 ? ? 'expression tag'        53  4  
1 8YQO THR A 5   ? UNP Q16850 ? ? 'expression tag'        54  5  
1 8YQO SER A 6   ? UNP Q16850 ? ? 'expression tag'        55  6  
1 8YQO SER A 7   ? UNP Q16850 ? ? 'expression tag'        56  7  
1 8YQO LYS A 8   ? UNP Q16850 ? ? 'expression tag'        57  8  
1 8YQO GLY A 9   ? UNP Q16850 ? ? 'expression tag'        58  9  
1 8YQO LYS A 10  ? UNP Q16850 ? ? 'expression tag'        59  10 
1 8YQO LEU A 11  ? UNP Q16850 ? ? 'expression tag'        60  11 
1 8YQO HIS A 455 ? UNP Q16850 ? ? 'expression tag'        504 12 
1 8YQO HIS A 456 ? UNP Q16850 ? ? 'expression tag'        505 13 
1 8YQO HIS A 457 ? UNP Q16850 ? ? 'expression tag'        506 14 
1 8YQO HIS A 458 ? UNP Q16850 ? ? 'expression tag'        507 15 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 HIS A 24  ? SER A 31  ? HIS A 73  SER A 80  1 ? 8  
HELX_P HELX_P2  AA2 SER A 31  ? GLY A 44  ? SER A 80  GLY A 93  1 ? 14 
HELX_P HELX_P3  AA3 GLY A 61  ? SER A 71  ? GLY A 110 SER A 120 1 ? 11 
HELX_P HELX_P4  AA4 ALA A 78  ? GLY A 91  ? ALA A 127 GLY A 140 1 ? 14 
HELX_P HELX_P5  AA5 PRO A 99  ? LEU A 114 ? PRO A 148 LEU A 163 1 ? 16 
HELX_P HELX_P6  AA6 ASN A 115 ? PHE A 134 ? ASN A 164 PHE A 183 1 ? 20 
HELX_P HELX_P7  AA7 VAL A 145 ? HIS A 162 ? VAL A 194 HIS A 211 1 ? 18 
HELX_P HELX_P8  AA8 GLY A 163 ? LEU A 170 ? GLY A 212 LEU A 219 1 ? 8  
HELX_P HELX_P9  AA9 ASN A 171 ? GLY A 183 ? ASN A 220 GLY A 232 1 ? 13 
HELX_P HELX_P10 AB1 SER A 186 ? LEU A 192 ? SER A 235 LEU A 241 1 ? 7  
HELX_P HELX_P11 AB2 LEU A 198 ? SER A 225 ? LEU A 247 SER A 274 1 ? 28 
HELX_P HELX_P12 AB3 ASP A 231 ? ALA A 239 ? ASP A 280 ALA A 288 1 ? 9  
HELX_P HELX_P13 AB4 THR A 248 ? ASP A 281 ? THR A 297 ASP A 330 1 ? 34 
HELX_P HELX_P14 AB5 ASP A 281 ? VAL A 295 ? ASP A 330 VAL A 344 1 ? 15 
HELX_P HELX_P15 AB6 THR A 304 ? LYS A 309 ? THR A 353 LYS A 358 1 ? 6  
HELX_P HELX_P16 AB7 LEU A 311 ? ARG A 325 ? LEU A 360 ARG A 374 1 ? 15 
HELX_P HELX_P17 AB8 THR A 357 ? ARG A 361 ? THR A 406 ARG A 410 5 ? 5  
HELX_P HELX_P18 AB9 ASP A 375 ? GLN A 379 ? ASP A 424 GLN A 428 5 ? 5  
HELX_P HELX_P19 AC1 ASN A 381 ? GLU A 386 ? ASN A 430 GLU A 435 1 ? 6  
HELX_P HELX_P20 AC2 GLY A 402 ? LEU A 420 ? GLY A 451 LEU A 469 1 ? 19 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            metalc1 
_struct_conn.conn_type_id                  metalc 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            400 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           HEM 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           FE 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             449 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            HEM 
_struct_conn.ptnr2_auth_seq_id             601 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.280 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG ? A CYS 400 ? A CYS 449 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NA ? B HEM . ? A HEM 601 ? 1_555 89.1  ? 
2  SG ? A CYS 400 ? A CYS 449 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NB ? B HEM . ? A HEM 601 ? 1_555 103.6 ? 
3  NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NB ? B HEM . ? A HEM 601 ? 1_555 88.9  ? 
4  SG ? A CYS 400 ? A CYS 449 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NC ? B HEM . ? A HEM 601 ? 1_555 91.1  ? 
5  NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NC ? B HEM . ? A HEM 601 ? 1_555 179.5 ? 
6  NB ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NC ? B HEM . ? A HEM 601 ? 1_555 90.7  ? 
7  SG ? A CYS 400 ? A CYS 449 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND ? B HEM . ? A HEM 601 ? 1_555 71.1  ? 
8  NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND ? B HEM . ? A HEM 601 ? 1_555 90.4  ? 
9  NB ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND ? B HEM . ? A HEM 601 ? 1_555 174.6 ? 
10 NC ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND ? B HEM . ? A HEM 601 ? 1_555 90.1  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 76  ? ASN A 77  ? LEU A 125 ASN A 126 
AA1 2 MET A 334 ? ALA A 335 ? MET A 383 ALA A 384 
AA2 1 SER A 140 ? ASN A 144 ? SER A 189 ASN A 193 
AA2 2 VAL A 446 ? ARG A 451 ? VAL A 495 ARG A 500 
AA2 3 TYR A 421 ? LEU A 425 ? TYR A 470 LEU A 474 
AA3 1 GLN A 339 ? VAL A 341 ? GLN A 388 VAL A 390 
AA3 2 TYR A 344 ? ILE A 346 ? TYR A 393 ILE A 395 
AA4 1 GLY A 394 ? ALA A 395 ? GLY A 443 ALA A 444 
AA4 2 HIS A 398 ? ARG A 399 ? HIS A 447 ARG A 448 
AA5 1 VAL A 433 ? ASN A 434 ? VAL A 482 ASN A 483 
AA5 2 THR A 441 ? PRO A 442 ? THR A 490 PRO A 491 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASN A 77  ? N ASN A 126 O MET A 334 ? O MET A 383 
AA2 1 2 N GLY A 141 ? N GLY A 190 O TYR A 449 ? O TYR A 498 
AA2 2 3 O LYS A 450 ? O LYS A 499 N GLU A 422 ? N GLU A 471 
AA3 1 2 N GLN A 339 ? N GLN A 388 O ILE A 346 ? O ILE A 395 
AA4 1 2 N ALA A 395 ? N ALA A 444 O HIS A 398 ? O HIS A 447 
AA5 1 2 N ASN A 434 ? N ASN A 483 O THR A 441 ? O THR A 490 
# 
_pdbx_entry_details.entry_id                   8YQO 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 80  ? ? -154.98 82.31   
2 1 ALA A 144 ? ? 63.59   -121.16 
3 1 PRO A 148 ? ? -59.41  170.98  
4 1 PRO A 405 ? ? -66.06  3.19    
5 1 GLU A 417 ? ? 39.23   63.53   
6 1 PRO A 423 ? ? -77.14  44.32   
7 1 ASP A 476 ? ? 57.40   18.43   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8YQO 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8YQO 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.52 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               287217 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.2 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Lanosterol 14-alpha demethylase' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8YQO 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      0.01 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          1000 
_em_imaging.calibrated_defocus_max          2000 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           64000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8YQO 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   281.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8YQO 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 50  ? A MET 1   
2  1 Y 1 A ALA 51  ? A ALA 2   
3  1 Y 1 A LYS 52  ? A LYS 3   
4  1 Y 1 A LYS 53  ? A LYS 4   
5  1 Y 1 A THR 54  ? A THR 5   
6  1 Y 1 A SER 55  ? A SER 6   
7  1 Y 1 A SER 56  ? A SER 7   
8  1 Y 1 A LYS 57  ? A LYS 8   
9  1 Y 1 A LYS 503 ? A LYS 454 
10 1 Y 1 A HIS 504 ? A HIS 455 
11 1 Y 1 A HIS 505 ? A HIS 456 
12 1 Y 1 A HIS 506 ? A HIS 457 
13 1 Y 1 A HIS 507 ? A HIS 458 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D61 C01  C  Y N 1   
A1D61 C04  C  Y N 2   
A1D61 C06  C  Y N 3   
A1D61 C02  C  Y N 4   
A1D61 C03  C  Y N 5   
A1D61 C10  C  Y N 6   
A1D61 C11  C  N N 7   
A1D61 C13  C  N N 8   
A1D61 C15  C  N N 9   
A1D61 C16  C  N N 10  
A1D61 C08  C  N N 11  
A1D61 C09  C  N N 12  
A1D61 C17  C  Y N 13  
A1D61 C18  C  Y N 14  
A1D61 C19  C  Y N 15  
A1D61 C20  C  Y N 16  
A1D61 C21  C  Y N 17  
A1D61 C22  C  Y N 18  
A1D61 C24  C  N N 19  
A1D61 C25  C  Y N 20  
A1D61 C26  C  Y N 21  
A1D61 C27  C  Y N 22  
A1D61 C28  C  Y N 23  
A1D61 C29  C  Y N 24  
A1D61 C31  C  Y N 25  
A1D61 C33  C  N N 26  
A1D61 N14  N  N N 27  
A1D61 O05  O  N N 28  
A1D61 O07  O  N N 29  
A1D61 O12  O  N N 30  
A1D61 O23  O  N N 31  
A1D61 O30  O  N N 32  
A1D61 O32  O  N N 33  
A1D61 H1   H  N N 34  
A1D61 H2   H  N N 35  
A1D61 H3   H  N N 36  
A1D61 H5   H  N N 37  
A1D61 H6   H  N N 38  
A1D61 H7   H  N N 39  
A1D61 H8   H  N N 40  
A1D61 H9   H  N N 41  
A1D61 H10  H  N N 42  
A1D61 H11  H  N N 43  
A1D61 H12  H  N N 44  
A1D61 H13  H  N N 45  
A1D61 H14  H  N N 46  
A1D61 H15  H  N N 47  
A1D61 H16  H  N N 48  
A1D61 H17  H  N N 49  
A1D61 H18  H  N N 50  
A1D61 H19  H  N N 51  
A1D61 H21  H  N N 52  
A1D61 H22  H  N N 53  
A1D61 H23  H  N N 54  
A1D61 H24  H  N N 55  
A1D61 H25  H  N N 56  
A1D61 H26  H  N N 57  
A1D61 H27  H  N N 58  
A1D61 H28  H  N N 59  
A1D61 H29  H  N N 60  
ALA   N    N  N N 61  
ALA   CA   C  N S 62  
ALA   C    C  N N 63  
ALA   O    O  N N 64  
ALA   CB   C  N N 65  
ALA   OXT  O  N N 66  
ALA   H    H  N N 67  
ALA   H2   H  N N 68  
ALA   HA   H  N N 69  
ALA   HB1  H  N N 70  
ALA   HB2  H  N N 71  
ALA   HB3  H  N N 72  
ALA   HXT  H  N N 73  
ARG   N    N  N N 74  
ARG   CA   C  N S 75  
ARG   C    C  N N 76  
ARG   O    O  N N 77  
ARG   CB   C  N N 78  
ARG   CG   C  N N 79  
ARG   CD   C  N N 80  
ARG   NE   N  N N 81  
ARG   CZ   C  N N 82  
ARG   NH1  N  N N 83  
ARG   NH2  N  N N 84  
ARG   OXT  O  N N 85  
ARG   H    H  N N 86  
ARG   H2   H  N N 87  
ARG   HA   H  N N 88  
ARG   HB2  H  N N 89  
ARG   HB3  H  N N 90  
ARG   HG2  H  N N 91  
ARG   HG3  H  N N 92  
ARG   HD2  H  N N 93  
ARG   HD3  H  N N 94  
ARG   HE   H  N N 95  
ARG   HH11 H  N N 96  
ARG   HH12 H  N N 97  
ARG   HH21 H  N N 98  
ARG   HH22 H  N N 99  
ARG   HXT  H  N N 100 
ASN   N    N  N N 101 
ASN   CA   C  N S 102 
ASN   C    C  N N 103 
ASN   O    O  N N 104 
ASN   CB   C  N N 105 
ASN   CG   C  N N 106 
ASN   OD1  O  N N 107 
ASN   ND2  N  N N 108 
ASN   OXT  O  N N 109 
ASN   H    H  N N 110 
ASN   H2   H  N N 111 
ASN   HA   H  N N 112 
ASN   HB2  H  N N 113 
ASN   HB3  H  N N 114 
ASN   HD21 H  N N 115 
ASN   HD22 H  N N 116 
ASN   HXT  H  N N 117 
ASP   N    N  N N 118 
ASP   CA   C  N S 119 
ASP   C    C  N N 120 
ASP   O    O  N N 121 
ASP   CB   C  N N 122 
ASP   CG   C  N N 123 
ASP   OD1  O  N N 124 
ASP   OD2  O  N N 125 
ASP   OXT  O  N N 126 
ASP   H    H  N N 127 
ASP   H2   H  N N 128 
ASP   HA   H  N N 129 
ASP   HB2  H  N N 130 
ASP   HB3  H  N N 131 
ASP   HD2  H  N N 132 
ASP   HXT  H  N N 133 
CYS   N    N  N N 134 
CYS   CA   C  N R 135 
CYS   C    C  N N 136 
CYS   O    O  N N 137 
CYS   CB   C  N N 138 
CYS   SG   S  N N 139 
CYS   OXT  O  N N 140 
CYS   H    H  N N 141 
CYS   H2   H  N N 142 
CYS   HA   H  N N 143 
CYS   HB2  H  N N 144 
CYS   HB3  H  N N 145 
CYS   HG   H  N N 146 
CYS   HXT  H  N N 147 
GLN   N    N  N N 148 
GLN   CA   C  N S 149 
GLN   C    C  N N 150 
GLN   O    O  N N 151 
GLN   CB   C  N N 152 
GLN   CG   C  N N 153 
GLN   CD   C  N N 154 
GLN   OE1  O  N N 155 
GLN   NE2  N  N N 156 
GLN   OXT  O  N N 157 
GLN   H    H  N N 158 
GLN   H2   H  N N 159 
GLN   HA   H  N N 160 
GLN   HB2  H  N N 161 
GLN   HB3  H  N N 162 
GLN   HG2  H  N N 163 
GLN   HG3  H  N N 164 
GLN   HE21 H  N N 165 
GLN   HE22 H  N N 166 
GLN   HXT  H  N N 167 
GLU   N    N  N N 168 
GLU   CA   C  N S 169 
GLU   C    C  N N 170 
GLU   O    O  N N 171 
GLU   CB   C  N N 172 
GLU   CG   C  N N 173 
GLU   CD   C  N N 174 
GLU   OE1  O  N N 175 
GLU   OE2  O  N N 176 
GLU   OXT  O  N N 177 
GLU   H    H  N N 178 
GLU   H2   H  N N 179 
GLU   HA   H  N N 180 
GLU   HB2  H  N N 181 
GLU   HB3  H  N N 182 
GLU   HG2  H  N N 183 
GLU   HG3  H  N N 184 
GLU   HE2  H  N N 185 
GLU   HXT  H  N N 186 
GLY   N    N  N N 187 
GLY   CA   C  N N 188 
GLY   C    C  N N 189 
GLY   O    O  N N 190 
GLY   OXT  O  N N 191 
GLY   H    H  N N 192 
GLY   H2   H  N N 193 
GLY   HA2  H  N N 194 
GLY   HA3  H  N N 195 
GLY   HXT  H  N N 196 
HEM   CHA  C  N N 197 
HEM   CHB  C  N N 198 
HEM   CHC  C  N N 199 
HEM   CHD  C  N N 200 
HEM   C1A  C  Y N 201 
HEM   C2A  C  Y N 202 
HEM   C3A  C  Y N 203 
HEM   C4A  C  Y N 204 
HEM   CMA  C  N N 205 
HEM   CAA  C  N N 206 
HEM   CBA  C  N N 207 
HEM   CGA  C  N N 208 
HEM   O1A  O  N N 209 
HEM   O2A  O  N N 210 
HEM   C1B  C  N N 211 
HEM   C2B  C  N N 212 
HEM   C3B  C  N N 213 
HEM   C4B  C  N N 214 
HEM   CMB  C  N N 215 
HEM   CAB  C  N N 216 
HEM   CBB  C  N N 217 
HEM   C1C  C  Y N 218 
HEM   C2C  C  Y N 219 
HEM   C3C  C  Y N 220 
HEM   C4C  C  Y N 221 
HEM   CMC  C  N N 222 
HEM   CAC  C  N N 223 
HEM   CBC  C  N N 224 
HEM   C1D  C  N N 225 
HEM   C2D  C  N N 226 
HEM   C3D  C  N N 227 
HEM   C4D  C  N N 228 
HEM   CMD  C  N N 229 
HEM   CAD  C  N N 230 
HEM   CBD  C  N N 231 
HEM   CGD  C  N N 232 
HEM   O1D  O  N N 233 
HEM   O2D  O  N N 234 
HEM   NA   N  Y N 235 
HEM   NB   N  N N 236 
HEM   NC   N  Y N 237 
HEM   ND   N  N N 238 
HEM   FE   FE N N 239 
HEM   HHB  H  N N 240 
HEM   HHC  H  N N 241 
HEM   HHD  H  N N 242 
HEM   HMA  H  N N 243 
HEM   HMAA H  N N 244 
HEM   HMAB H  N N 245 
HEM   HAA  H  N N 246 
HEM   HAAA H  N N 247 
HEM   HBA  H  N N 248 
HEM   HBAA H  N N 249 
HEM   HMB  H  N N 250 
HEM   HMBA H  N N 251 
HEM   HMBB H  N N 252 
HEM   HAB  H  N N 253 
HEM   HBB  H  N N 254 
HEM   HBBA H  N N 255 
HEM   HMC  H  N N 256 
HEM   HMCA H  N N 257 
HEM   HMCB H  N N 258 
HEM   HAC  H  N N 259 
HEM   HBC  H  N N 260 
HEM   HBCA H  N N 261 
HEM   HMD  H  N N 262 
HEM   HMDA H  N N 263 
HEM   HMDB H  N N 264 
HEM   HAD  H  N N 265 
HEM   HADA H  N N 266 
HEM   HBD  H  N N 267 
HEM   HBDA H  N N 268 
HEM   H2A  H  N N 269 
HEM   H2D  H  N N 270 
HEM   HHA  H  N N 271 
HIS   N    N  N N 272 
HIS   CA   C  N S 273 
HIS   C    C  N N 274 
HIS   O    O  N N 275 
HIS   CB   C  N N 276 
HIS   CG   C  Y N 277 
HIS   ND1  N  Y N 278 
HIS   CD2  C  Y N 279 
HIS   CE1  C  Y N 280 
HIS   NE2  N  Y N 281 
HIS   OXT  O  N N 282 
HIS   H    H  N N 283 
HIS   H2   H  N N 284 
HIS   HA   H  N N 285 
HIS   HB2  H  N N 286 
HIS   HB3  H  N N 287 
HIS   HD1  H  N N 288 
HIS   HD2  H  N N 289 
HIS   HE1  H  N N 290 
HIS   HE2  H  N N 291 
HIS   HXT  H  N N 292 
ILE   N    N  N N 293 
ILE   CA   C  N S 294 
ILE   C    C  N N 295 
ILE   O    O  N N 296 
ILE   CB   C  N S 297 
ILE   CG1  C  N N 298 
ILE   CG2  C  N N 299 
ILE   CD1  C  N N 300 
ILE   OXT  O  N N 301 
ILE   H    H  N N 302 
ILE   H2   H  N N 303 
ILE   HA   H  N N 304 
ILE   HB   H  N N 305 
ILE   HG12 H  N N 306 
ILE   HG13 H  N N 307 
ILE   HG21 H  N N 308 
ILE   HG22 H  N N 309 
ILE   HG23 H  N N 310 
ILE   HD11 H  N N 311 
ILE   HD12 H  N N 312 
ILE   HD13 H  N N 313 
ILE   HXT  H  N N 314 
LEU   N    N  N N 315 
LEU   CA   C  N S 316 
LEU   C    C  N N 317 
LEU   O    O  N N 318 
LEU   CB   C  N N 319 
LEU   CG   C  N N 320 
LEU   CD1  C  N N 321 
LEU   CD2  C  N N 322 
LEU   OXT  O  N N 323 
LEU   H    H  N N 324 
LEU   H2   H  N N 325 
LEU   HA   H  N N 326 
LEU   HB2  H  N N 327 
LEU   HB3  H  N N 328 
LEU   HG   H  N N 329 
LEU   HD11 H  N N 330 
LEU   HD12 H  N N 331 
LEU   HD13 H  N N 332 
LEU   HD21 H  N N 333 
LEU   HD22 H  N N 334 
LEU   HD23 H  N N 335 
LEU   HXT  H  N N 336 
LYS   N    N  N N 337 
LYS   CA   C  N S 338 
LYS   C    C  N N 339 
LYS   O    O  N N 340 
LYS   CB   C  N N 341 
LYS   CG   C  N N 342 
LYS   CD   C  N N 343 
LYS   CE   C  N N 344 
LYS   NZ   N  N N 345 
LYS   OXT  O  N N 346 
LYS   H    H  N N 347 
LYS   H2   H  N N 348 
LYS   HA   H  N N 349 
LYS   HB2  H  N N 350 
LYS   HB3  H  N N 351 
LYS   HG2  H  N N 352 
LYS   HG3  H  N N 353 
LYS   HD2  H  N N 354 
LYS   HD3  H  N N 355 
LYS   HE2  H  N N 356 
LYS   HE3  H  N N 357 
LYS   HZ1  H  N N 358 
LYS   HZ2  H  N N 359 
LYS   HZ3  H  N N 360 
LYS   HXT  H  N N 361 
MET   N    N  N N 362 
MET   CA   C  N S 363 
MET   C    C  N N 364 
MET   O    O  N N 365 
MET   CB   C  N N 366 
MET   CG   C  N N 367 
MET   SD   S  N N 368 
MET   CE   C  N N 369 
MET   OXT  O  N N 370 
MET   H    H  N N 371 
MET   H2   H  N N 372 
MET   HA   H  N N 373 
MET   HB2  H  N N 374 
MET   HB3  H  N N 375 
MET   HG2  H  N N 376 
MET   HG3  H  N N 377 
MET   HE1  H  N N 378 
MET   HE2  H  N N 379 
MET   HE3  H  N N 380 
MET   HXT  H  N N 381 
PHE   N    N  N N 382 
PHE   CA   C  N S 383 
PHE   C    C  N N 384 
PHE   O    O  N N 385 
PHE   CB   C  N N 386 
PHE   CG   C  Y N 387 
PHE   CD1  C  Y N 388 
PHE   CD2  C  Y N 389 
PHE   CE1  C  Y N 390 
PHE   CE2  C  Y N 391 
PHE   CZ   C  Y N 392 
PHE   OXT  O  N N 393 
PHE   H    H  N N 394 
PHE   H2   H  N N 395 
PHE   HA   H  N N 396 
PHE   HB2  H  N N 397 
PHE   HB3  H  N N 398 
PHE   HD1  H  N N 399 
PHE   HD2  H  N N 400 
PHE   HE1  H  N N 401 
PHE   HE2  H  N N 402 
PHE   HZ   H  N N 403 
PHE   HXT  H  N N 404 
PRO   N    N  N N 405 
PRO   CA   C  N S 406 
PRO   C    C  N N 407 
PRO   O    O  N N 408 
PRO   CB   C  N N 409 
PRO   CG   C  N N 410 
PRO   CD   C  N N 411 
PRO   OXT  O  N N 412 
PRO   H    H  N N 413 
PRO   HA   H  N N 414 
PRO   HB2  H  N N 415 
PRO   HB3  H  N N 416 
PRO   HG2  H  N N 417 
PRO   HG3  H  N N 418 
PRO   HD2  H  N N 419 
PRO   HD3  H  N N 420 
PRO   HXT  H  N N 421 
SER   N    N  N N 422 
SER   CA   C  N S 423 
SER   C    C  N N 424 
SER   O    O  N N 425 
SER   CB   C  N N 426 
SER   OG   O  N N 427 
SER   OXT  O  N N 428 
SER   H    H  N N 429 
SER   H2   H  N N 430 
SER   HA   H  N N 431 
SER   HB2  H  N N 432 
SER   HB3  H  N N 433 
SER   HG   H  N N 434 
SER   HXT  H  N N 435 
THR   N    N  N N 436 
THR   CA   C  N S 437 
THR   C    C  N N 438 
THR   O    O  N N 439 
THR   CB   C  N R 440 
THR   OG1  O  N N 441 
THR   CG2  C  N N 442 
THR   OXT  O  N N 443 
THR   H    H  N N 444 
THR   H2   H  N N 445 
THR   HA   H  N N 446 
THR   HB   H  N N 447 
THR   HG1  H  N N 448 
THR   HG21 H  N N 449 
THR   HG22 H  N N 450 
THR   HG23 H  N N 451 
THR   HXT  H  N N 452 
TRP   N    N  N N 453 
TRP   CA   C  N S 454 
TRP   C    C  N N 455 
TRP   O    O  N N 456 
TRP   CB   C  N N 457 
TRP   CG   C  Y N 458 
TRP   CD1  C  Y N 459 
TRP   CD2  C  Y N 460 
TRP   NE1  N  Y N 461 
TRP   CE2  C  Y N 462 
TRP   CE3  C  Y N 463 
TRP   CZ2  C  Y N 464 
TRP   CZ3  C  Y N 465 
TRP   CH2  C  Y N 466 
TRP   OXT  O  N N 467 
TRP   H    H  N N 468 
TRP   H2   H  N N 469 
TRP   HA   H  N N 470 
TRP   HB2  H  N N 471 
TRP   HB3  H  N N 472 
TRP   HD1  H  N N 473 
TRP   HE1  H  N N 474 
TRP   HE3  H  N N 475 
TRP   HZ2  H  N N 476 
TRP   HZ3  H  N N 477 
TRP   HH2  H  N N 478 
TRP   HXT  H  N N 479 
TYR   N    N  N N 480 
TYR   CA   C  N S 481 
TYR   C    C  N N 482 
TYR   O    O  N N 483 
TYR   CB   C  N N 484 
TYR   CG   C  Y N 485 
TYR   CD1  C  Y N 486 
TYR   CD2  C  Y N 487 
TYR   CE1  C  Y N 488 
TYR   CE2  C  Y N 489 
TYR   CZ   C  Y N 490 
TYR   OH   O  N N 491 
TYR   OXT  O  N N 492 
TYR   H    H  N N 493 
TYR   H2   H  N N 494 
TYR   HA   H  N N 495 
TYR   HB2  H  N N 496 
TYR   HB3  H  N N 497 
TYR   HD1  H  N N 498 
TYR   HD2  H  N N 499 
TYR   HE1  H  N N 500 
TYR   HE2  H  N N 501 
TYR   HH   H  N N 502 
TYR   HXT  H  N N 503 
VAL   N    N  N N 504 
VAL   CA   C  N S 505 
VAL   C    C  N N 506 
VAL   O    O  N N 507 
VAL   CB   C  N N 508 
VAL   CG1  C  N N 509 
VAL   CG2  C  N N 510 
VAL   OXT  O  N N 511 
VAL   H    H  N N 512 
VAL   H2   H  N N 513 
VAL   HA   H  N N 514 
VAL   HB   H  N N 515 
VAL   HG11 H  N N 516 
VAL   HG12 H  N N 517 
VAL   HG13 H  N N 518 
VAL   HG21 H  N N 519 
VAL   HG22 H  N N 520 
VAL   HG23 H  N N 521 
VAL   HXT  H  N N 522 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D61 C27 C28  doub Y N 1   
A1D61 C27 C29  sing Y N 2   
A1D61 C28 C25  sing Y N 3   
A1D61 O30 C29  sing N N 4   
A1D61 C29 C31  doub Y N 5   
A1D61 C25 C24  sing N N 6   
A1D61 C25 C26  doub Y N 7   
A1D61 C24 C11  doub N E 8   
A1D61 C31 C26  sing Y N 9   
A1D61 C31 O32  sing N N 10  
A1D61 O32 C33  sing N N 11  
A1D61 C11 C13  sing N N 12  
A1D61 C11 C10  sing N N 13  
A1D61 C03 C10  doub Y N 14  
A1D61 C03 C04  sing Y N 15  
A1D61 O05 C08  sing N N 16  
A1D61 O05 C04  sing N N 17  
A1D61 C13 N14  sing N N 18  
A1D61 C13 O12  doub N N 19  
A1D61 C16 C17  sing N N 20  
A1D61 C16 C15  sing N N 21  
A1D61 C10 C06  sing Y N 22  
A1D61 N14 C15  sing N N 23  
A1D61 C04 C01  doub Y N 24  
A1D61 C21 C17  doub Y N 25  
A1D61 C21 C20  sing Y N 26  
A1D61 C17 C18  sing Y N 27  
A1D61 C20 C22  doub Y N 28  
A1D61 C18 C19  doub Y N 29  
A1D61 C06 O07  sing N N 30  
A1D61 C06 C02  doub Y N 31  
A1D61 C22 C19  sing Y N 32  
A1D61 C22 O23  sing N N 33  
A1D61 C01 C02  sing Y N 34  
A1D61 O07 C09  sing N N 35  
A1D61 C01 H1   sing N N 36  
A1D61 C02 H2   sing N N 37  
A1D61 C03 H3   sing N N 38  
A1D61 C15 H5   sing N N 39  
A1D61 C15 H6   sing N N 40  
A1D61 C16 H7   sing N N 41  
A1D61 C16 H8   sing N N 42  
A1D61 C08 H9   sing N N 43  
A1D61 C08 H10  sing N N 44  
A1D61 C08 H11  sing N N 45  
A1D61 C09 H12  sing N N 46  
A1D61 C09 H13  sing N N 47  
A1D61 C09 H14  sing N N 48  
A1D61 C18 H15  sing N N 49  
A1D61 C19 H16  sing N N 50  
A1D61 C20 H17  sing N N 51  
A1D61 C21 H18  sing N N 52  
A1D61 C24 H19  sing N N 53  
A1D61 C26 H21  sing N N 54  
A1D61 C27 H22  sing N N 55  
A1D61 C28 H23  sing N N 56  
A1D61 C33 H24  sing N N 57  
A1D61 C33 H25  sing N N 58  
A1D61 C33 H26  sing N N 59  
A1D61 N14 H27  sing N N 60  
A1D61 O23 H28  sing N N 61  
A1D61 O30 H29  sing N N 62  
ALA   N   CA   sing N N 63  
ALA   N   H    sing N N 64  
ALA   N   H2   sing N N 65  
ALA   CA  C    sing N N 66  
ALA   CA  CB   sing N N 67  
ALA   CA  HA   sing N N 68  
ALA   C   O    doub N N 69  
ALA   C   OXT  sing N N 70  
ALA   CB  HB1  sing N N 71  
ALA   CB  HB2  sing N N 72  
ALA   CB  HB3  sing N N 73  
ALA   OXT HXT  sing N N 74  
ARG   N   CA   sing N N 75  
ARG   N   H    sing N N 76  
ARG   N   H2   sing N N 77  
ARG   CA  C    sing N N 78  
ARG   CA  CB   sing N N 79  
ARG   CA  HA   sing N N 80  
ARG   C   O    doub N N 81  
ARG   C   OXT  sing N N 82  
ARG   CB  CG   sing N N 83  
ARG   CB  HB2  sing N N 84  
ARG   CB  HB3  sing N N 85  
ARG   CG  CD   sing N N 86  
ARG   CG  HG2  sing N N 87  
ARG   CG  HG3  sing N N 88  
ARG   CD  NE   sing N N 89  
ARG   CD  HD2  sing N N 90  
ARG   CD  HD3  sing N N 91  
ARG   NE  CZ   sing N N 92  
ARG   NE  HE   sing N N 93  
ARG   CZ  NH1  sing N N 94  
ARG   CZ  NH2  doub N N 95  
ARG   NH1 HH11 sing N N 96  
ARG   NH1 HH12 sing N N 97  
ARG   NH2 HH21 sing N N 98  
ARG   NH2 HH22 sing N N 99  
ARG   OXT HXT  sing N N 100 
ASN   N   CA   sing N N 101 
ASN   N   H    sing N N 102 
ASN   N   H2   sing N N 103 
ASN   CA  C    sing N N 104 
ASN   CA  CB   sing N N 105 
ASN   CA  HA   sing N N 106 
ASN   C   O    doub N N 107 
ASN   C   OXT  sing N N 108 
ASN   CB  CG   sing N N 109 
ASN   CB  HB2  sing N N 110 
ASN   CB  HB3  sing N N 111 
ASN   CG  OD1  doub N N 112 
ASN   CG  ND2  sing N N 113 
ASN   ND2 HD21 sing N N 114 
ASN   ND2 HD22 sing N N 115 
ASN   OXT HXT  sing N N 116 
ASP   N   CA   sing N N 117 
ASP   N   H    sing N N 118 
ASP   N   H2   sing N N 119 
ASP   CA  C    sing N N 120 
ASP   CA  CB   sing N N 121 
ASP   CA  HA   sing N N 122 
ASP   C   O    doub N N 123 
ASP   C   OXT  sing N N 124 
ASP   CB  CG   sing N N 125 
ASP   CB  HB2  sing N N 126 
ASP   CB  HB3  sing N N 127 
ASP   CG  OD1  doub N N 128 
ASP   CG  OD2  sing N N 129 
ASP   OD2 HD2  sing N N 130 
ASP   OXT HXT  sing N N 131 
CYS   N   CA   sing N N 132 
CYS   N   H    sing N N 133 
CYS   N   H2   sing N N 134 
CYS   CA  C    sing N N 135 
CYS   CA  CB   sing N N 136 
CYS   CA  HA   sing N N 137 
CYS   C   O    doub N N 138 
CYS   C   OXT  sing N N 139 
CYS   CB  SG   sing N N 140 
CYS   CB  HB2  sing N N 141 
CYS   CB  HB3  sing N N 142 
CYS   SG  HG   sing N N 143 
CYS   OXT HXT  sing N N 144 
GLN   N   CA   sing N N 145 
GLN   N   H    sing N N 146 
GLN   N   H2   sing N N 147 
GLN   CA  C    sing N N 148 
GLN   CA  CB   sing N N 149 
GLN   CA  HA   sing N N 150 
GLN   C   O    doub N N 151 
GLN   C   OXT  sing N N 152 
GLN   CB  CG   sing N N 153 
GLN   CB  HB2  sing N N 154 
GLN   CB  HB3  sing N N 155 
GLN   CG  CD   sing N N 156 
GLN   CG  HG2  sing N N 157 
GLN   CG  HG3  sing N N 158 
GLN   CD  OE1  doub N N 159 
GLN   CD  NE2  sing N N 160 
GLN   NE2 HE21 sing N N 161 
GLN   NE2 HE22 sing N N 162 
GLN   OXT HXT  sing N N 163 
GLU   N   CA   sing N N 164 
GLU   N   H    sing N N 165 
GLU   N   H2   sing N N 166 
GLU   CA  C    sing N N 167 
GLU   CA  CB   sing N N 168 
GLU   CA  HA   sing N N 169 
GLU   C   O    doub N N 170 
GLU   C   OXT  sing N N 171 
GLU   CB  CG   sing N N 172 
GLU   CB  HB2  sing N N 173 
GLU   CB  HB3  sing N N 174 
GLU   CG  CD   sing N N 175 
GLU   CG  HG2  sing N N 176 
GLU   CG  HG3  sing N N 177 
GLU   CD  OE1  doub N N 178 
GLU   CD  OE2  sing N N 179 
GLU   OE2 HE2  sing N N 180 
GLU   OXT HXT  sing N N 181 
GLY   N   CA   sing N N 182 
GLY   N   H    sing N N 183 
GLY   N   H2   sing N N 184 
GLY   CA  C    sing N N 185 
GLY   CA  HA2  sing N N 186 
GLY   CA  HA3  sing N N 187 
GLY   C   O    doub N N 188 
GLY   C   OXT  sing N N 189 
GLY   OXT HXT  sing N N 190 
HEM   CHA C1A  sing N N 191 
HEM   CHA C4D  doub N N 192 
HEM   CHA HHA  sing N N 193 
HEM   CHB C4A  sing N N 194 
HEM   CHB C1B  doub N N 195 
HEM   CHB HHB  sing N N 196 
HEM   CHC C4B  sing N N 197 
HEM   CHC C1C  doub N N 198 
HEM   CHC HHC  sing N N 199 
HEM   CHD C4C  doub N N 200 
HEM   CHD C1D  sing N N 201 
HEM   CHD HHD  sing N N 202 
HEM   C1A C2A  doub Y N 203 
HEM   C1A NA   sing Y N 204 
HEM   C2A C3A  sing Y N 205 
HEM   C2A CAA  sing N N 206 
HEM   C3A C4A  doub Y N 207 
HEM   C3A CMA  sing N N 208 
HEM   C4A NA   sing Y N 209 
HEM   CMA HMA  sing N N 210 
HEM   CMA HMAA sing N N 211 
HEM   CMA HMAB sing N N 212 
HEM   CAA CBA  sing N N 213 
HEM   CAA HAA  sing N N 214 
HEM   CAA HAAA sing N N 215 
HEM   CBA CGA  sing N N 216 
HEM   CBA HBA  sing N N 217 
HEM   CBA HBAA sing N N 218 
HEM   CGA O1A  doub N N 219 
HEM   CGA O2A  sing N N 220 
HEM   C1B C2B  sing N N 221 
HEM   C1B NB   sing N N 222 
HEM   C2B C3B  doub N N 223 
HEM   C2B CMB  sing N N 224 
HEM   C3B C4B  sing N N 225 
HEM   C3B CAB  sing N N 226 
HEM   C4B NB   doub N N 227 
HEM   CMB HMB  sing N N 228 
HEM   CMB HMBA sing N N 229 
HEM   CMB HMBB sing N N 230 
HEM   CAB CBB  doub N N 231 
HEM   CAB HAB  sing N N 232 
HEM   CBB HBB  sing N N 233 
HEM   CBB HBBA sing N N 234 
HEM   C1C C2C  sing Y N 235 
HEM   C1C NC   sing Y N 236 
HEM   C2C C3C  doub Y N 237 
HEM   C2C CMC  sing N N 238 
HEM   C3C C4C  sing Y N 239 
HEM   C3C CAC  sing N N 240 
HEM   C4C NC   sing Y N 241 
HEM   CMC HMC  sing N N 242 
HEM   CMC HMCA sing N N 243 
HEM   CMC HMCB sing N N 244 
HEM   CAC CBC  doub N N 245 
HEM   CAC HAC  sing N N 246 
HEM   CBC HBC  sing N N 247 
HEM   CBC HBCA sing N N 248 
HEM   C1D C2D  sing N N 249 
HEM   C1D ND   doub N N 250 
HEM   C2D C3D  doub N N 251 
HEM   C2D CMD  sing N N 252 
HEM   C3D C4D  sing N N 253 
HEM   C3D CAD  sing N N 254 
HEM   C4D ND   sing N N 255 
HEM   CMD HMD  sing N N 256 
HEM   CMD HMDA sing N N 257 
HEM   CMD HMDB sing N N 258 
HEM   CAD CBD  sing N N 259 
HEM   CAD HAD  sing N N 260 
HEM   CAD HADA sing N N 261 
HEM   CBD CGD  sing N N 262 
HEM   CBD HBD  sing N N 263 
HEM   CBD HBDA sing N N 264 
HEM   CGD O1D  doub N N 265 
HEM   CGD O2D  sing N N 266 
HEM   O2A H2A  sing N N 267 
HEM   O2D H2D  sing N N 268 
HEM   FE  NA   sing N N 269 
HEM   FE  NB   sing N N 270 
HEM   FE  NC   sing N N 271 
HEM   FE  ND   sing N N 272 
HIS   N   CA   sing N N 273 
HIS   N   H    sing N N 274 
HIS   N   H2   sing N N 275 
HIS   CA  C    sing N N 276 
HIS   CA  CB   sing N N 277 
HIS   CA  HA   sing N N 278 
HIS   C   O    doub N N 279 
HIS   C   OXT  sing N N 280 
HIS   CB  CG   sing N N 281 
HIS   CB  HB2  sing N N 282 
HIS   CB  HB3  sing N N 283 
HIS   CG  ND1  sing Y N 284 
HIS   CG  CD2  doub Y N 285 
HIS   ND1 CE1  doub Y N 286 
HIS   ND1 HD1  sing N N 287 
HIS   CD2 NE2  sing Y N 288 
HIS   CD2 HD2  sing N N 289 
HIS   CE1 NE2  sing Y N 290 
HIS   CE1 HE1  sing N N 291 
HIS   NE2 HE2  sing N N 292 
HIS   OXT HXT  sing N N 293 
ILE   N   CA   sing N N 294 
ILE   N   H    sing N N 295 
ILE   N   H2   sing N N 296 
ILE   CA  C    sing N N 297 
ILE   CA  CB   sing N N 298 
ILE   CA  HA   sing N N 299 
ILE   C   O    doub N N 300 
ILE   C   OXT  sing N N 301 
ILE   CB  CG1  sing N N 302 
ILE   CB  CG2  sing N N 303 
ILE   CB  HB   sing N N 304 
ILE   CG1 CD1  sing N N 305 
ILE   CG1 HG12 sing N N 306 
ILE   CG1 HG13 sing N N 307 
ILE   CG2 HG21 sing N N 308 
ILE   CG2 HG22 sing N N 309 
ILE   CG2 HG23 sing N N 310 
ILE   CD1 HD11 sing N N 311 
ILE   CD1 HD12 sing N N 312 
ILE   CD1 HD13 sing N N 313 
ILE   OXT HXT  sing N N 314 
LEU   N   CA   sing N N 315 
LEU   N   H    sing N N 316 
LEU   N   H2   sing N N 317 
LEU   CA  C    sing N N 318 
LEU   CA  CB   sing N N 319 
LEU   CA  HA   sing N N 320 
LEU   C   O    doub N N 321 
LEU   C   OXT  sing N N 322 
LEU   CB  CG   sing N N 323 
LEU   CB  HB2  sing N N 324 
LEU   CB  HB3  sing N N 325 
LEU   CG  CD1  sing N N 326 
LEU   CG  CD2  sing N N 327 
LEU   CG  HG   sing N N 328 
LEU   CD1 HD11 sing N N 329 
LEU   CD1 HD12 sing N N 330 
LEU   CD1 HD13 sing N N 331 
LEU   CD2 HD21 sing N N 332 
LEU   CD2 HD22 sing N N 333 
LEU   CD2 HD23 sing N N 334 
LEU   OXT HXT  sing N N 335 
LYS   N   CA   sing N N 336 
LYS   N   H    sing N N 337 
LYS   N   H2   sing N N 338 
LYS   CA  C    sing N N 339 
LYS   CA  CB   sing N N 340 
LYS   CA  HA   sing N N 341 
LYS   C   O    doub N N 342 
LYS   C   OXT  sing N N 343 
LYS   CB  CG   sing N N 344 
LYS   CB  HB2  sing N N 345 
LYS   CB  HB3  sing N N 346 
LYS   CG  CD   sing N N 347 
LYS   CG  HG2  sing N N 348 
LYS   CG  HG3  sing N N 349 
LYS   CD  CE   sing N N 350 
LYS   CD  HD2  sing N N 351 
LYS   CD  HD3  sing N N 352 
LYS   CE  NZ   sing N N 353 
LYS   CE  HE2  sing N N 354 
LYS   CE  HE3  sing N N 355 
LYS   NZ  HZ1  sing N N 356 
LYS   NZ  HZ2  sing N N 357 
LYS   NZ  HZ3  sing N N 358 
LYS   OXT HXT  sing N N 359 
MET   N   CA   sing N N 360 
MET   N   H    sing N N 361 
MET   N   H2   sing N N 362 
MET   CA  C    sing N N 363 
MET   CA  CB   sing N N 364 
MET   CA  HA   sing N N 365 
MET   C   O    doub N N 366 
MET   C   OXT  sing N N 367 
MET   CB  CG   sing N N 368 
MET   CB  HB2  sing N N 369 
MET   CB  HB3  sing N N 370 
MET   CG  SD   sing N N 371 
MET   CG  HG2  sing N N 372 
MET   CG  HG3  sing N N 373 
MET   SD  CE   sing N N 374 
MET   CE  HE1  sing N N 375 
MET   CE  HE2  sing N N 376 
MET   CE  HE3  sing N N 377 
MET   OXT HXT  sing N N 378 
PHE   N   CA   sing N N 379 
PHE   N   H    sing N N 380 
PHE   N   H2   sing N N 381 
PHE   CA  C    sing N N 382 
PHE   CA  CB   sing N N 383 
PHE   CA  HA   sing N N 384 
PHE   C   O    doub N N 385 
PHE   C   OXT  sing N N 386 
PHE   CB  CG   sing N N 387 
PHE   CB  HB2  sing N N 388 
PHE   CB  HB3  sing N N 389 
PHE   CG  CD1  doub Y N 390 
PHE   CG  CD2  sing Y N 391 
PHE   CD1 CE1  sing Y N 392 
PHE   CD1 HD1  sing N N 393 
PHE   CD2 CE2  doub Y N 394 
PHE   CD2 HD2  sing N N 395 
PHE   CE1 CZ   doub Y N 396 
PHE   CE1 HE1  sing N N 397 
PHE   CE2 CZ   sing Y N 398 
PHE   CE2 HE2  sing N N 399 
PHE   CZ  HZ   sing N N 400 
PHE   OXT HXT  sing N N 401 
PRO   N   CA   sing N N 402 
PRO   N   CD   sing N N 403 
PRO   N   H    sing N N 404 
PRO   CA  C    sing N N 405 
PRO   CA  CB   sing N N 406 
PRO   CA  HA   sing N N 407 
PRO   C   O    doub N N 408 
PRO   C   OXT  sing N N 409 
PRO   CB  CG   sing N N 410 
PRO   CB  HB2  sing N N 411 
PRO   CB  HB3  sing N N 412 
PRO   CG  CD   sing N N 413 
PRO   CG  HG2  sing N N 414 
PRO   CG  HG3  sing N N 415 
PRO   CD  HD2  sing N N 416 
PRO   CD  HD3  sing N N 417 
PRO   OXT HXT  sing N N 418 
SER   N   CA   sing N N 419 
SER   N   H    sing N N 420 
SER   N   H2   sing N N 421 
SER   CA  C    sing N N 422 
SER   CA  CB   sing N N 423 
SER   CA  HA   sing N N 424 
SER   C   O    doub N N 425 
SER   C   OXT  sing N N 426 
SER   CB  OG   sing N N 427 
SER   CB  HB2  sing N N 428 
SER   CB  HB3  sing N N 429 
SER   OG  HG   sing N N 430 
SER   OXT HXT  sing N N 431 
THR   N   CA   sing N N 432 
THR   N   H    sing N N 433 
THR   N   H2   sing N N 434 
THR   CA  C    sing N N 435 
THR   CA  CB   sing N N 436 
THR   CA  HA   sing N N 437 
THR   C   O    doub N N 438 
THR   C   OXT  sing N N 439 
THR   CB  OG1  sing N N 440 
THR   CB  CG2  sing N N 441 
THR   CB  HB   sing N N 442 
THR   OG1 HG1  sing N N 443 
THR   CG2 HG21 sing N N 444 
THR   CG2 HG22 sing N N 445 
THR   CG2 HG23 sing N N 446 
THR   OXT HXT  sing N N 447 
TRP   N   CA   sing N N 448 
TRP   N   H    sing N N 449 
TRP   N   H2   sing N N 450 
TRP   CA  C    sing N N 451 
TRP   CA  CB   sing N N 452 
TRP   CA  HA   sing N N 453 
TRP   C   O    doub N N 454 
TRP   C   OXT  sing N N 455 
TRP   CB  CG   sing N N 456 
TRP   CB  HB2  sing N N 457 
TRP   CB  HB3  sing N N 458 
TRP   CG  CD1  doub Y N 459 
TRP   CG  CD2  sing Y N 460 
TRP   CD1 NE1  sing Y N 461 
TRP   CD1 HD1  sing N N 462 
TRP   CD2 CE2  doub Y N 463 
TRP   CD2 CE3  sing Y N 464 
TRP   NE1 CE2  sing Y N 465 
TRP   NE1 HE1  sing N N 466 
TRP   CE2 CZ2  sing Y N 467 
TRP   CE3 CZ3  doub Y N 468 
TRP   CE3 HE3  sing N N 469 
TRP   CZ2 CH2  doub Y N 470 
TRP   CZ2 HZ2  sing N N 471 
TRP   CZ3 CH2  sing Y N 472 
TRP   CZ3 HZ3  sing N N 473 
TRP   CH2 HH2  sing N N 474 
TRP   OXT HXT  sing N N 475 
TYR   N   CA   sing N N 476 
TYR   N   H    sing N N 477 
TYR   N   H2   sing N N 478 
TYR   CA  C    sing N N 479 
TYR   CA  CB   sing N N 480 
TYR   CA  HA   sing N N 481 
TYR   C   O    doub N N 482 
TYR   C   OXT  sing N N 483 
TYR   CB  CG   sing N N 484 
TYR   CB  HB2  sing N N 485 
TYR   CB  HB3  sing N N 486 
TYR   CG  CD1  doub Y N 487 
TYR   CG  CD2  sing Y N 488 
TYR   CD1 CE1  sing Y N 489 
TYR   CD1 HD1  sing N N 490 
TYR   CD2 CE2  doub Y N 491 
TYR   CD2 HD2  sing N N 492 
TYR   CE1 CZ   doub Y N 493 
TYR   CE1 HE1  sing N N 494 
TYR   CE2 CZ   sing Y N 495 
TYR   CE2 HE2  sing N N 496 
TYR   CZ  OH   sing N N 497 
TYR   OH  HH   sing N N 498 
TYR   OXT HXT  sing N N 499 
VAL   N   CA   sing N N 500 
VAL   N   H    sing N N 501 
VAL   N   H2   sing N N 502 
VAL   CA  C    sing N N 503 
VAL   CA  CB   sing N N 504 
VAL   CA  HA   sing N N 505 
VAL   C   O    doub N N 506 
VAL   C   OXT  sing N N 507 
VAL   CB  CG1  sing N N 508 
VAL   CB  CG2  sing N N 509 
VAL   CB  HB   sing N N 510 
VAL   CG1 HG11 sing N N 511 
VAL   CG1 HG12 sing N N 512 
VAL   CG1 HG13 sing N N 513 
VAL   CG2 HG21 sing N N 514 
VAL   CG2 HG22 sing N N 515 
VAL   CG2 HG23 sing N N 516 
VAL   OXT HXT  sing N N 517 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-03-19 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8YQO 
_em_admin.last_update        2025-03-26 
_em_admin.map_release_date   2025-03-26 
_em_admin.title              'Cryo-EM structure of human lanosterol 14alpha-demethylase (CYP51) in complex with FLZ' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               2.56 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8YQO 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
FE 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLY   A 1 9   ? 112.766 141.328 170.640 1.00 141.28 ? 58  GLY   A N   1 
ATOM   2    C  CA  . GLY   A 1 9   ? 114.011 141.595 171.335 1.00 145.54 ? 58  GLY   A CA  1 
ATOM   3    C  C   . GLY   A 1 9   ? 114.591 142.959 171.021 1.00 147.65 ? 58  GLY   A C   1 
ATOM   4    O  O   . GLY   A 1 9   ? 114.286 143.550 169.985 1.00 148.24 ? 58  GLY   A O   1 
ATOM   5    N  N   . LYS   A 1 10  ? 115.431 143.462 171.920 1.00 138.55 ? 59  LYS   A N   1 
ATOM   6    C  CA  . LYS   A 1 10  ? 116.072 144.761 171.767 1.00 135.26 ? 59  LYS   A CA  1 
ATOM   7    C  C   . LYS   A 1 10  ? 117.580 144.590 171.858 1.00 135.70 ? 59  LYS   A C   1 
ATOM   8    O  O   . LYS   A 1 10  ? 118.084 143.976 172.805 1.00 139.47 ? 59  LYS   A O   1 
ATOM   9    C  CB  . LYS   A 1 10  ? 115.579 145.745 172.832 1.00 130.90 ? 59  LYS   A CB  1 
ATOM   10   C  CG  . LYS   A 1 10  ? 116.494 146.938 173.055 1.00 134.97 ? 59  LYS   A CG  1 
ATOM   11   C  CD  . LYS   A 1 10  ? 116.084 148.126 172.201 1.00 136.83 ? 59  LYS   A CD  1 
ATOM   12   C  CE  . LYS   A 1 10  ? 117.229 149.115 172.047 1.00 137.72 ? 59  LYS   A CE  1 
ATOM   13   N  NZ  . LYS   A 1 10  ? 116.746 150.485 171.720 1.00 134.09 ? 59  LYS   A NZ  1 
ATOM   14   N  N   . LEU   A 1 11  ? 118.295 145.127 170.874 1.00 124.16 ? 60  LEU   A N   1 
ATOM   15   C  CA  . LEU   A 1 11  ? 119.744 145.060 170.886 1.00 124.71 ? 60  LEU   A CA  1 
ATOM   16   C  C   . LEU   A 1 11  ? 120.304 145.940 172.003 1.00 130.94 ? 60  LEU   A C   1 
ATOM   17   O  O   . LEU   A 1 11  ? 119.717 146.970 172.345 1.00 131.84 ? 60  LEU   A O   1 
ATOM   18   C  CB  . LEU   A 1 11  ? 120.307 145.493 169.533 1.00 130.32 ? 60  LEU   A CB  1 
ATOM   19   C  CG  . LEU   A 1 11  ? 119.992 146.908 169.041 1.00 135.57 ? 60  LEU   A CG  1 
ATOM   20   C  CD1 . LEU   A 1 11  ? 121.200 147.819 169.187 1.00 130.42 ? 60  LEU   A CD1 1 
ATOM   21   C  CD2 . LEU   A 1 11  ? 119.502 146.889 167.601 1.00 132.28 ? 60  LEU   A CD2 1 
ATOM   22   N  N   . PRO   A 1 12  ? 121.433 145.548 172.598 1.00 116.65 ? 61  PRO   A N   1 
ATOM   23   C  CA  . PRO   A 1 12  ? 121.994 146.344 173.687 1.00 115.91 ? 61  PRO   A CA  1 
ATOM   24   C  C   . PRO   A 1 12  ? 122.452 147.699 173.182 1.00 119.55 ? 61  PRO   A C   1 
ATOM   25   O  O   . PRO   A 1 12  ? 122.769 147.857 171.991 1.00 120.20 ? 61  PRO   A O   1 
ATOM   26   C  CB  . PRO   A 1 12  ? 123.183 145.493 174.169 1.00 110.63 ? 61  PRO   A CB  1 
ATOM   27   C  CG  . PRO   A 1 12  ? 123.548 144.671 172.990 1.00 110.29 ? 61  PRO   A CG  1 
ATOM   28   C  CD  . PRO   A 1 12  ? 122.256 144.366 172.298 1.00 115.75 ? 61  PRO   A CD  1 
ATOM   29   N  N   . PRO   A 1 13  ? 122.479 148.725 174.054 1.00 124.07 ? 62  PRO   A N   1 
ATOM   30   C  CA  . PRO   A 1 13  ? 122.914 150.062 173.623 1.00 120.20 ? 62  PRO   A CA  1 
ATOM   31   C  C   . PRO   A 1 13  ? 124.233 150.025 172.872 1.00 116.78 ? 62  PRO   A C   1 
ATOM   32   O  O   . PRO   A 1 13  ? 125.283 149.726 173.447 1.00 122.47 ? 62  PRO   A O   1 
ATOM   33   C  CB  . PRO   A 1 13  ? 123.047 150.842 174.939 1.00 116.87 ? 62  PRO   A CB  1 
ATOM   34   C  CG  . PRO   A 1 13  ? 122.496 149.959 176.022 1.00 120.42 ? 62  PRO   A CG  1 
ATOM   35   C  CD  . PRO   A 1 13  ? 121.915 148.729 175.411 1.00 117.15 ? 62  PRO   A CD  1 
ATOM   36   N  N   . TYR   A 1 14  ? 124.181 150.341 171.584 1.00 115.36 ? 63  TYR   A N   1 
ATOM   37   C  CA  . TYR   A 1 14  ? 125.307 150.129 170.688 1.00 114.34 ? 63  TYR   A CA  1 
ATOM   38   C  C   . TYR   A 1 14  ? 126.116 151.411 170.550 1.00 117.98 ? 63  TYR   A C   1 
ATOM   39   O  O   . TYR   A 1 14  ? 125.579 152.455 170.170 1.00 123.85 ? 63  TYR   A O   1 
ATOM   40   C  CB  . TYR   A 1 14  ? 124.805 149.662 169.321 1.00 120.52 ? 63  TYR   A CB  1 
ATOM   41   C  CG  . TYR   A 1 14  ? 125.891 149.424 168.301 1.00 125.23 ? 63  TYR   A CG  1 
ATOM   42   C  CD1 . TYR   A 1 14  ? 127.131 148.935 168.680 1.00 122.99 ? 63  TYR   A CD1 1 
ATOM   43   C  CD2 . TYR   A 1 14  ? 125.673 149.685 166.955 1.00 129.68 ? 63  TYR   A CD2 1 
ATOM   44   C  CE1 . TYR   A 1 14  ? 128.121 148.716 167.752 1.00 126.58 ? 63  TYR   A CE1 1 
ATOM   45   C  CE2 . TYR   A 1 14  ? 126.661 149.469 166.018 1.00 125.33 ? 63  TYR   A CE2 1 
ATOM   46   C  CZ  . TYR   A 1 14  ? 127.884 148.985 166.423 1.00 125.72 ? 63  TYR   A CZ  1 
ATOM   47   O  OH  . TYR   A 1 14  ? 128.876 148.766 165.494 1.00 124.82 ? 63  TYR   A OH  1 
ATOM   48   N  N   . ILE   A 1 15  ? 127.410 151.325 170.862 1.00 123.62 ? 64  ILE   A N   1 
ATOM   49   C  CA  . ILE   A 1 15  ? 128.286 152.472 170.679 1.00 127.82 ? 64  ILE   A CA  1 
ATOM   50   C  C   . ILE   A 1 15  ? 128.516 152.712 169.190 1.00 134.19 ? 64  ILE   A C   1 
ATOM   51   O  O   . ILE   A 1 15  ? 128.357 151.818 168.349 1.00 128.53 ? 64  ILE   A O   1 
ATOM   52   C  CB  . ILE   A 1 15  ? 129.613 152.270 171.430 1.00 125.51 ? 64  ILE   A CB  1 
ATOM   53   C  CG1 . ILE   A 1 15  ? 130.086 153.585 172.047 1.00 123.14 ? 64  ILE   A CG1 1 
ATOM   54   C  CG2 . ILE   A 1 15  ? 130.678 151.696 170.511 1.00 129.03 ? 64  ILE   A CG2 1 
ATOM   55   C  CD1 . ILE   A 1 15  ? 131.148 153.406 173.106 1.00 125.85 ? 64  ILE   A CD1 1 
ATOM   56   N  N   . PHE   A 1 16  ? 128.881 153.946 168.858 1.00 154.37 ? 65  PHE   A N   1 
ATOM   57   C  CA  . PHE   A 1 16  ? 129.056 154.364 167.474 1.00 150.97 ? 65  PHE   A CA  1 
ATOM   58   C  C   . PHE   A 1 16  ? 130.530 154.628 167.198 1.00 148.53 ? 65  PHE   A C   1 
ATOM   59   O  O   . PHE   A 1 16  ? 131.170 155.408 167.910 1.00 149.00 ? 65  PHE   A O   1 
ATOM   60   C  CB  . PHE   A 1 16  ? 128.219 155.607 167.170 1.00 149.74 ? 65  PHE   A CB  1 
ATOM   61   C  CG  . PHE   A 1 16  ? 126.774 155.304 166.893 1.00 153.91 ? 65  PHE   A CG  1 
ATOM   62   C  CD1 . PHE   A 1 16  ? 126.420 154.410 165.897 1.00 152.93 ? 65  PHE   A CD1 1 
ATOM   63   C  CD2 . PHE   A 1 16  ? 125.770 155.904 167.635 1.00 151.47 ? 65  PHE   A CD2 1 
ATOM   64   C  CE1 . PHE   A 1 16  ? 125.093 154.124 165.641 1.00 150.22 ? 65  PHE   A CE1 1 
ATOM   65   C  CE2 . PHE   A 1 16  ? 124.441 155.623 167.383 1.00 149.92 ? 65  PHE   A CE2 1 
ATOM   66   C  CZ  . PHE   A 1 16  ? 124.102 154.731 166.385 1.00 151.66 ? 65  PHE   A CZ  1 
ATOM   67   N  N   . SER   A 1 17  ? 131.059 153.973 166.161 1.00 159.78 ? 66  SER   A N   1 
ATOM   68   C  CA  . SER   A 1 17  ? 132.466 154.014 165.784 1.00 162.51 ? 66  SER   A CA  1 
ATOM   69   C  C   . SER   A 1 17  ? 132.664 154.859 164.538 1.00 163.63 ? 66  SER   A C   1 
ATOM   70   O  O   . SER   A 1 17  ? 132.004 154.608 163.519 1.00 164.78 ? 66  SER   A O   1 
ATOM   71   C  CB  . SER   A 1 17  ? 132.990 152.605 165.532 1.00 160.01 ? 66  SER   A CB  1 
ATOM   72   O  OG  . SER   A 1 17  ? 134.180 152.647 164.767 1.00 158.85 ? 66  SER   A OG  1 
ATOM   73   N  N   . PRO   A 1 18  ? 133.543 155.863 164.577 1.00 160.75 ? 67  PRO   A N   1 
ATOM   74   C  CA  . PRO   A 1 18  ? 133.865 156.597 163.343 1.00 158.91 ? 67  PRO   A CA  1 
ATOM   75   C  C   . PRO   A 1 18  ? 134.445 155.715 162.251 1.00 156.85 ? 67  PRO   A C   1 
ATOM   76   O  O   . PRO   A 1 18  ? 134.155 155.935 161.069 1.00 157.67 ? 67  PRO   A O   1 
ATOM   77   C  CB  . PRO   A 1 18  ? 134.879 157.649 163.816 1.00 158.93 ? 67  PRO   A CB  1 
ATOM   78   C  CG  . PRO   A 1 18  ? 134.643 157.776 165.289 1.00 158.41 ? 67  PRO   A CG  1 
ATOM   79   C  CD  . PRO   A 1 18  ? 134.252 156.406 165.747 1.00 157.83 ? 67  PRO   A CD  1 
ATOM   80   N  N   . ILE   A 1 19  ? 135.253 154.723 162.611 1.00 159.80 ? 68  ILE   A N   1 
ATOM   81   C  CA  . ILE   A 1 19  ? 135.883 153.826 161.644 1.00 162.45 ? 68  ILE   A CA  1 
ATOM   82   C  C   . ILE   A 1 19  ? 134.945 152.657 161.366 1.00 161.96 ? 68  ILE   A C   1 
ATOM   83   O  O   . ILE   A 1 19  ? 134.407 152.058 162.308 1.00 164.03 ? 68  ILE   A O   1 
ATOM   84   C  CB  . ILE   A 1 19  ? 137.253 153.340 162.144 1.00 163.17 ? 68  ILE   A CB  1 
ATOM   85   C  CG1 . ILE   A 1 19  ? 138.130 154.530 162.539 1.00 160.87 ? 68  ILE   A CG1 1 
ATOM   86   C  CG2 . ILE   A 1 19  ? 137.945 152.500 161.082 1.00 162.29 ? 68  ILE   A CG2 1 
ATOM   87   C  CD1 . ILE   A 1 19  ? 138.214 154.767 164.031 1.00 161.35 ? 68  ILE   A CD1 1 
ATOM   88   N  N   . PRO   A 1 20  ? 134.710 152.309 160.097 1.00 165.67 ? 69  PRO   A N   1 
ATOM   89   C  CA  . PRO   A 1 20  ? 133.742 151.234 159.807 1.00 169.87 ? 69  PRO   A CA  1 
ATOM   90   C  C   . PRO   A 1 20  ? 134.162 149.865 160.319 1.00 170.38 ? 69  PRO   A C   1 
ATOM   91   O  O   . PRO   A 1 20  ? 133.357 149.173 160.957 1.00 168.57 ? 69  PRO   A O   1 
ATOM   92   C  CB  . PRO   A 1 20  ? 133.646 151.268 158.274 1.00 167.62 ? 69  PRO   A CB  1 
ATOM   93   C  CG  . PRO   A 1 20  ? 134.069 152.648 157.897 1.00 166.03 ? 69  PRO   A CG  1 
ATOM   94   C  CD  . PRO   A 1 20  ? 135.146 153.000 158.874 1.00 167.06 ? 69  PRO   A CD  1 
ATOM   95   N  N   . PHE   A 1 21  ? 135.399 149.447 160.055 1.00 170.36 ? 70  PHE   A N   1 
ATOM   96   C  CA  . PHE   A 1 21  ? 135.840 148.094 160.378 1.00 170.43 ? 70  PHE   A CA  1 
ATOM   97   C  C   . PHE   A 1 21  ? 136.675 148.022 161.650 1.00 168.81 ? 70  PHE   A C   1 
ATOM   98   O  O   . PHE   A 1 21  ? 136.349 147.255 162.560 1.00 170.22 ? 70  PHE   A O   1 
ATOM   99   C  CB  . PHE   A 1 21  ? 136.638 147.508 159.209 1.00 170.74 ? 70  PHE   A CB  1 
ATOM   100  C  CG  . PHE   A 1 21  ? 137.002 146.065 159.391 1.00 168.73 ? 70  PHE   A CG  1 
ATOM   101  C  CD1 . PHE   A 1 21  ? 136.025 145.084 159.377 1.00 168.78 ? 70  PHE   A CD1 1 
ATOM   102  C  CD2 . PHE   A 1 21  ? 138.319 145.689 159.583 1.00 168.02 ? 70  PHE   A CD2 1 
ATOM   103  C  CE1 . PHE   A 1 21  ? 136.357 143.754 159.545 1.00 169.23 ? 70  PHE   A CE1 1 
ATOM   104  C  CE2 . PHE   A 1 21  ? 138.658 144.361 159.751 1.00 169.86 ? 70  PHE   A CE2 1 
ATOM   105  C  CZ  . PHE   A 1 21  ? 137.676 143.393 159.732 1.00 170.62 ? 70  PHE   A CZ  1 
ATOM   106  N  N   . LEU   A 1 22  ? 137.758 148.800 161.725 1.00 162.08 ? 71  LEU   A N   1 
ATOM   107  C  CA  . LEU   A 1 22  ? 138.662 148.703 162.867 1.00 161.95 ? 71  LEU   A CA  1 
ATOM   108  C  C   . LEU   A 1 22  ? 137.960 149.097 164.162 1.00 160.50 ? 71  LEU   A C   1 
ATOM   109  O  O   . LEU   A 1 22  ? 138.153 148.455 165.201 1.00 160.40 ? 71  LEU   A O   1 
ATOM   110  C  CB  . LEU   A 1 22  ? 139.906 149.559 162.614 1.00 161.90 ? 71  LEU   A CB  1 
ATOM   111  C  CG  . LEU   A 1 22  ? 140.862 149.969 163.739 1.00 163.36 ? 71  LEU   A CG  1 
ATOM   112  C  CD1 . LEU   A 1 22  ? 142.237 150.238 163.159 1.00 164.54 ? 71  LEU   A CD1 1 
ATOM   113  C  CD2 . LEU   A 1 22  ? 140.375 151.212 164.457 1.00 161.02 ? 71  LEU   A CD2 1 
ATOM   114  N  N   . GLY   A 1 23  ? 137.150 150.147 164.122 1.00 163.88 ? 72  GLY   A N   1 
ATOM   115  C  CA  . GLY   A 1 23  ? 136.355 150.491 165.290 1.00 165.28 ? 72  GLY   A CA  1 
ATOM   116  C  C   . GLY   A 1 23  ? 137.167 151.228 166.337 1.00 168.56 ? 72  GLY   A C   1 
ATOM   117  O  O   . GLY   A 1 23  ? 137.867 152.203 166.043 1.00 171.63 ? 72  GLY   A O   1 
ATOM   118  N  N   . HIS   A 1 24  ? 137.063 150.770 167.585 1.00 160.69 ? 73  HIS   A N   1 
ATOM   119  C  CA  . HIS   A 1 24  ? 137.749 151.387 168.713 1.00 157.68 ? 73  HIS   A CA  1 
ATOM   120  C  C   . HIS   A 1 24  ? 138.990 150.607 169.130 1.00 159.24 ? 73  HIS   A C   1 
ATOM   121  O  O   . HIS   A 1 24  ? 139.334 150.577 170.317 1.00 161.68 ? 73  HIS   A O   1 
ATOM   122  C  CB  . HIS   A 1 24  ? 136.792 151.532 169.896 1.00 156.70 ? 73  HIS   A CB  1 
ATOM   123  C  CG  . HIS   A 1 24  ? 135.473 152.137 169.534 1.00 158.07 ? 73  HIS   A CG  1 
ATOM   124  N  ND1 . HIS   A 1 24  ? 135.196 153.476 169.704 1.00 159.28 ? 73  HIS   A ND1 1 
ATOM   125  C  CD2 . HIS   A 1 24  ? 134.353 151.585 169.010 1.00 159.34 ? 73  HIS   A CD2 1 
ATOM   126  C  CE1 . HIS   A 1 24  ? 133.962 153.723 169.301 1.00 160.01 ? 73  HIS   A CE1 1 
ATOM   127  N  NE2 . HIS   A 1 24  ? 133.429 152.593 168.874 1.00 160.80 ? 73  HIS   A NE2 1 
ATOM   128  N  N   . ALA   A 1 25  ? 139.667 149.971 168.172 1.00 160.25 ? 74  ALA   A N   1 
ATOM   129  C  CA  . ALA   A 1 25  ? 140.835 149.160 168.501 1.00 163.31 ? 74  ALA   A CA  1 
ATOM   130  C  C   . ALA   A 1 25  ? 141.948 150.010 169.100 1.00 163.57 ? 74  ALA   A C   1 
ATOM   131  O  O   . ALA   A 1 25  ? 142.561 149.632 170.105 1.00 163.81 ? 74  ALA   A O   1 
ATOM   132  C  CB  . ALA   A 1 25  ? 141.326 148.424 167.255 1.00 164.45 ? 74  ALA   A CB  1 
ATOM   133  N  N   . ILE   A 1 26  ? 142.220 151.171 168.498 1.00 166.49 ? 75  ILE   A N   1 
ATOM   134  C  CA  . ILE   A 1 26  ? 143.287 152.031 168.999 1.00 168.29 ? 75  ILE   A CA  1 
ATOM   135  C  C   . ILE   A 1 26  ? 142.954 152.546 170.393 1.00 166.72 ? 75  ILE   A C   1 
ATOM   136  O  O   . ILE   A 1 26  ? 143.814 152.572 171.280 1.00 168.81 ? 75  ILE   A O   1 
ATOM   137  C  CB  . ILE   A 1 26  ? 143.557 153.188 168.020 1.00 166.97 ? 75  ILE   A CB  1 
ATOM   138  C  CG1 . ILE   A 1 26  ? 143.961 152.650 166.648 1.00 166.58 ? 75  ILE   A CG1 1 
ATOM   139  C  CG2 . ILE   A 1 26  ? 144.637 154.108 168.565 1.00 164.75 ? 75  ILE   A CG2 1 
ATOM   140  C  CD1 . ILE   A 1 26  ? 143.128 153.194 165.515 1.00 164.14 ? 75  ILE   A CD1 1 
ATOM   141  N  N   . ALA   A 1 27  ? 141.706 152.968 170.610 1.00 166.51 ? 76  ALA   A N   1 
ATOM   142  C  CA  . ALA   A 1 27  ? 141.319 153.474 171.923 1.00 168.71 ? 76  ALA   A CA  1 
ATOM   143  C  C   . ALA   A 1 27  ? 141.403 152.384 172.984 1.00 168.96 ? 76  ALA   A C   1 
ATOM   144  O  O   . ALA   A 1 27  ? 141.860 152.633 174.109 1.00 169.87 ? 76  ALA   A O   1 
ATOM   145  C  CB  . ALA   A 1 27  ? 139.909 154.060 171.864 1.00 167.95 ? 76  ALA   A CB  1 
ATOM   146  N  N   . PHE   A 1 28  ? 140.961 151.170 172.648 1.00 163.13 ? 77  PHE   A N   1 
ATOM   147  C  CA  . PHE   A 1 28  ? 141.021 150.073 173.607 1.00 164.13 ? 77  PHE   A CA  1 
ATOM   148  C  C   . PHE   A 1 28  ? 142.461 149.682 173.910 1.00 165.04 ? 77  PHE   A C   1 
ATOM   149  O  O   . PHE   A 1 28  ? 142.785 149.330 175.048 1.00 164.38 ? 77  PHE   A O   1 
ATOM   150  C  CB  . PHE   A 1 28  ? 140.232 148.873 173.089 1.00 163.24 ? 77  PHE   A CB  1 
ATOM   151  C  CG  . PHE   A 1 28  ? 139.613 148.048 174.178 1.00 162.20 ? 77  PHE   A CG  1 
ATOM   152  C  CD1 . PHE   A 1 28  ? 138.675 148.601 175.031 1.00 163.28 ? 77  PHE   A CD1 1 
ATOM   153  C  CD2 . PHE   A 1 28  ? 139.973 146.725 174.356 1.00 161.47 ? 77  PHE   A CD2 1 
ATOM   154  C  CE1 . PHE   A 1 28  ? 138.107 147.850 176.038 1.00 162.22 ? 77  PHE   A CE1 1 
ATOM   155  C  CE2 . PHE   A 1 28  ? 139.406 145.969 175.361 1.00 159.37 ? 77  PHE   A CE2 1 
ATOM   156  C  CZ  . PHE   A 1 28  ? 138.472 146.534 176.203 1.00 158.41 ? 77  PHE   A CZ  1 
ATOM   157  N  N   . GLY   A 1 29  ? 143.336 149.720 172.904 1.00 169.00 ? 78  GLY   A N   1 
ATOM   158  C  CA  . GLY   A 1 29  ? 144.743 149.472 173.163 1.00 167.85 ? 78  GLY   A CA  1 
ATOM   159  C  C   . GLY   A 1 29  ? 145.377 150.559 174.010 1.00 166.11 ? 78  GLY   A C   1 
ATOM   160  O  O   . GLY   A 1 29  ? 146.245 150.284 174.843 1.00 164.24 ? 78  GLY   A O   1 
ATOM   161  N  N   . LYS   A 1 30  ? 144.954 151.808 173.808 1.00 174.56 ? 79  LYS   A N   1 
ATOM   162  C  CA  . LYS   A 1 30  ? 145.547 152.922 174.540 1.00 175.46 ? 79  LYS   A CA  1 
ATOM   163  C  C   . LYS   A 1 30  ? 145.137 152.905 176.006 1.00 174.29 ? 79  LYS   A C   1 
ATOM   164  O  O   . LYS   A 1 30  ? 145.980 153.061 176.897 1.00 175.88 ? 79  LYS   A O   1 
ATOM   165  C  CB  . LYS   A 1 30  ? 145.151 154.246 173.885 1.00 175.70 ? 79  LYS   A CB  1 
ATOM   166  C  CG  . LYS   A 1 30  ? 146.305 154.972 173.216 1.00 175.49 ? 79  LYS   A CG  1 
ATOM   167  C  CD  . LYS   A 1 30  ? 146.424 154.581 171.752 1.00 176.40 ? 79  LYS   A CD  1 
ATOM   168  C  CE  . LYS   A 1 30  ? 147.361 155.513 171.001 1.00 176.17 ? 79  LYS   A CE  1 
ATOM   169  N  NZ  . LYS   A 1 30  ? 147.942 154.861 169.795 1.00 175.97 ? 79  LYS   A NZ  1 
ATOM   170  N  N   . SER   A 1 31  ? 143.847 152.719 176.281 1.00 167.79 ? 80  SER   A N   1 
ATOM   171  C  CA  . SER   A 1 31  ? 143.336 152.743 177.653 1.00 168.73 ? 80  SER   A CA  1 
ATOM   172  C  C   . SER   A 1 31  ? 142.056 151.929 177.735 1.00 170.14 ? 80  SER   A C   1 
ATOM   173  O  O   . SER   A 1 31  ? 140.945 152.472 177.707 1.00 170.94 ? 80  SER   A O   1 
ATOM   174  C  CB  . SER   A 1 31  ? 143.098 154.176 178.128 1.00 169.87 ? 80  SER   A CB  1 
ATOM   175  O  OG  . SER   A 1 31  ? 143.080 154.243 179.543 1.00 170.58 ? 80  SER   A OG  1 
ATOM   176  N  N   . PRO   A 1 32  ? 142.175 150.604 177.864 1.00 163.40 ? 81  PRO   A N   1 
ATOM   177  C  CA  . PRO   A 1 32  ? 140.961 149.774 177.903 1.00 162.66 ? 81  PRO   A CA  1 
ATOM   178  C  C   . PRO   A 1 32  ? 140.115 150.003 179.140 1.00 164.74 ? 81  PRO   A C   1 
ATOM   179  O  O   . PRO   A 1 32  ? 138.887 150.095 179.027 1.00 167.17 ? 81  PRO   A O   1 
ATOM   180  C  CB  . PRO   A 1 32  ? 141.515 148.344 177.845 1.00 161.74 ? 81  PRO   A CB  1 
ATOM   181  C  CG  . PRO   A 1 32  ? 142.885 148.450 178.411 1.00 161.08 ? 81  PRO   A CG  1 
ATOM   182  C  CD  . PRO   A 1 32  ? 143.402 149.813 178.047 1.00 160.90 ? 81  PRO   A CD  1 
ATOM   183  N  N   . ILE   A 1 33  ? 140.731 150.098 180.320 1.00 158.22 ? 82  ILE   A N   1 
ATOM   184  C  CA  . ILE   A 1 33  ? 139.961 150.259 181.550 1.00 158.29 ? 82  ILE   A CA  1 
ATOM   185  C  C   . ILE   A 1 33  ? 139.216 151.587 181.544 1.00 157.86 ? 82  ILE   A C   1 
ATOM   186  O  O   . ILE   A 1 33  ? 138.019 151.646 181.844 1.00 157.65 ? 82  ILE   A O   1 
ATOM   187  C  CB  . ILE   A 1 33  ? 140.878 150.136 182.780 1.00 154.94 ? 82  ILE   A CB  1 
ATOM   188  C  CG1 . ILE   A 1 33  ? 141.647 148.815 182.744 1.00 155.53 ? 82  ILE   A CG1 1 
ATOM   189  C  CG2 . ILE   A 1 33  ? 140.066 150.245 184.061 1.00 153.33 ? 82  ILE   A CG2 1 
ATOM   190  C  CD1 . ILE   A 1 33  ? 143.016 148.883 183.389 1.00 155.45 ? 82  ILE   A CD1 1 
ATOM   191  N  N   . GLU   A 1 34  ? 139.911 152.672 181.193 1.00 152.91 ? 83  GLU   A N   1 
ATOM   192  C  CA  . GLU   A 1 34  ? 139.265 153.981 181.142 1.00 153.86 ? 83  GLU   A CA  1 
ATOM   193  C  C   . GLU   A 1 34  ? 138.192 154.027 180.062 1.00 155.91 ? 83  GLU   A C   1 
ATOM   194  O  O   . GLU   A 1 34  ? 137.127 154.631 180.258 1.00 160.41 ? 83  GLU   A O   1 
ATOM   195  C  CB  . GLU   A 1 34  ? 140.309 155.076 180.905 1.00 153.88 ? 83  GLU   A CB  1 
ATOM   196  C  CG  . GLU   A 1 34  ? 139.783 156.504 180.618 1.00 155.79 ? 83  GLU   A CG  1 
ATOM   197  C  CD  . GLU   A 1 34  ? 138.665 157.010 181.543 1.00 156.09 ? 83  GLU   A CD  1 
ATOM   198  O  OE1 . GLU   A 1 34  ? 138.229 158.162 181.330 1.00 156.02 ? 83  GLU   A OE1 1 
ATOM   199  O  OE2 . GLU   A 1 34  ? 138.242 156.319 182.495 1.00 156.53 ? 83  GLU   A OE2 1 
ATOM   200  N  N   . PHE   A 1 35  ? 138.460 153.407 178.910 1.00 146.96 ? 84  PHE   A N   1 
ATOM   201  C  CA  . PHE   A 1 35  ? 137.478 153.410 177.833 1.00 149.25 ? 84  PHE   A CA  1 
ATOM   202  C  C   . PHE   A 1 35  ? 136.216 152.679 178.270 1.00 148.58 ? 84  PHE   A C   1 
ATOM   203  O  O   . PHE   A 1 35  ? 135.099 153.166 178.064 1.00 152.90 ? 84  PHE   A O   1 
ATOM   204  C  CB  . PHE   A 1 35  ? 138.089 152.784 176.573 1.00 149.08 ? 84  PHE   A CB  1 
ATOM   205  C  CG  . PHE   A 1 35  ? 137.135 152.668 175.407 1.00 149.68 ? 84  PHE   A CG  1 
ATOM   206  C  CD1 . PHE   A 1 35  ? 137.230 153.556 174.348 1.00 150.94 ? 84  PHE   A CD1 1 
ATOM   207  C  CD2 . PHE   A 1 35  ? 136.184 151.664 175.340 1.00 146.79 ? 84  PHE   A CD2 1 
ATOM   208  C  CE1 . PHE   A 1 35  ? 136.376 153.469 173.266 1.00 151.52 ? 84  PHE   A CE1 1 
ATOM   209  C  CE2 . PHE   A 1 35  ? 135.326 151.578 174.258 1.00 148.05 ? 84  PHE   A CE2 1 
ATOM   210  C  CZ  . PHE   A 1 35  ? 135.425 152.476 173.221 1.00 152.73 ? 84  PHE   A CZ  1 
ATOM   211  N  N   . LEU   A 1 36  ? 136.380 151.520 178.914 1.00 139.07 ? 85  LEU   A N   1 
ATOM   212  C  CA  . LEU   A 1 36  ? 135.232 150.779 179.426 1.00 140.44 ? 85  LEU   A CA  1 
ATOM   213  C  C   . LEU   A 1 36  ? 134.496 151.571 180.496 1.00 143.07 ? 85  LEU   A C   1 
ATOM   214  O  O   . LEU   A 1 36  ? 133.262 151.566 180.542 1.00 145.58 ? 85  LEU   A O   1 
ATOM   215  C  CB  . LEU   A 1 36  ? 135.681 149.428 179.982 1.00 137.10 ? 85  LEU   A CB  1 
ATOM   216  C  CG  . LEU   A 1 36  ? 136.163 148.390 178.971 1.00 137.77 ? 85  LEU   A CG  1 
ATOM   217  C  CD1 . LEU   A 1 36  ? 137.076 147.376 179.639 1.00 139.04 ? 85  LEU   A CD1 1 
ATOM   218  C  CD2 . LEU   A 1 36  ? 134.979 147.704 178.329 1.00 137.18 ? 85  LEU   A CD2 1 
ATOM   219  N  N   . GLU   A 1 37  ? 135.236 152.253 181.372 1.00 152.48 ? 86  GLU   A N   1 
ATOM   220  C  CA  . GLU   A 1 37  ? 134.603 153.013 182.443 1.00 153.71 ? 86  GLU   A CA  1 
ATOM   221  C  C   . GLU   A 1 37  ? 133.731 154.131 181.884 1.00 152.15 ? 86  GLU   A C   1 
ATOM   222  O  O   . GLU   A 1 37  ? 132.557 154.265 182.254 1.00 151.34 ? 86  GLU   A O   1 
ATOM   223  C  CB  . GLU   A 1 37  ? 135.671 153.577 183.379 1.00 155.75 ? 86  GLU   A CB  1 
ATOM   224  C  CG  . GLU   A 1 37  ? 135.385 153.357 184.852 1.00 157.30 ? 86  GLU   A CG  1 
ATOM   225  C  CD  . GLU   A 1 37  ? 136.644 153.383 185.695 1.00 156.92 ? 86  GLU   A CD  1 
ATOM   226  O  OE1 . GLU   A 1 37  ? 137.549 154.188 185.389 1.00 157.87 ? 86  GLU   A OE1 1 
ATOM   227  O  OE2 . GLU   A 1 37  ? 136.731 152.598 186.662 1.00 153.58 ? 86  GLU   A OE2 1 
ATOM   228  N  N   . ASN   A 1 38  ? 134.287 154.943 180.980 1.00 145.32 ? 87  ASN   A N   1 
ATOM   229  C  CA  . ASN   A 1 38  ? 133.497 156.035 180.420 1.00 147.18 ? 87  ASN   A CA  1 
ATOM   230  C  C   . ASN   A 1 38  ? 132.357 155.513 179.553 1.00 148.71 ? 87  ASN   A C   1 
ATOM   231  O  O   . ASN   A 1 38  ? 131.268 156.101 179.550 1.00 150.11 ? 87  ASN   A O   1 
ATOM   232  C  CB  . ASN   A 1 38  ? 134.384 157.006 179.637 1.00 146.73 ? 87  ASN   A CB  1 
ATOM   233  C  CG  . ASN   A 1 38  ? 135.113 156.347 178.488 1.00 148.78 ? 87  ASN   A CG  1 
ATOM   234  O  OD1 . ASN   A 1 38  ? 134.498 155.844 177.548 1.00 148.63 ? 87  ASN   A OD1 1 
ATOM   235  N  ND2 . ASN   A 1 38  ? 136.438 156.367 178.546 1.00 151.13 ? 87  ASN   A ND2 1 
ATOM   236  N  N   . ALA   A 1 39  ? 132.572 154.410 178.829 1.00 144.82 ? 88  ALA   A N   1 
ATOM   237  C  CA  . ALA   A 1 39  ? 131.479 153.817 178.068 1.00 147.27 ? 88  ALA   A CA  1 
ATOM   238  C  C   . ALA   A 1 39  ? 130.362 153.350 178.991 1.00 146.17 ? 88  ALA   A C   1 
ATOM   239  O  O   . ALA   A 1 39  ? 129.181 153.467 178.652 1.00 146.45 ? 88  ALA   A O   1 
ATOM   240  C  CB  . ALA   A 1 39  ? 131.997 152.660 177.216 1.00 144.12 ? 88  ALA   A CB  1 
ATOM   241  N  N   . TYR   A 1 40  ? 130.716 152.814 180.160 1.00 138.65 ? 89  TYR   A N   1 
ATOM   242  C  CA  . TYR   A 1 40  ? 129.704 152.436 181.139 1.00 137.98 ? 89  TYR   A CA  1 
ATOM   243  C  C   . TYR   A 1 40  ? 128.928 153.656 181.613 1.00 136.46 ? 89  TYR   A C   1 
ATOM   244  O  O   . TYR   A 1 40  ? 127.691 153.659 181.608 1.00 139.90 ? 89  TYR   A O   1 
ATOM   245  C  CB  . TYR   A 1 40  ? 130.358 151.718 182.319 1.00 140.72 ? 89  TYR   A CB  1 
ATOM   246  C  CG  . TYR   A 1 40  ? 129.437 151.505 183.498 1.00 138.44 ? 89  TYR   A CG  1 
ATOM   247  C  CD1 . TYR   A 1 40  ? 128.320 150.691 183.394 1.00 133.87 ? 89  TYR   A CD1 1 
ATOM   248  C  CD2 . TYR   A 1 40  ? 129.688 152.116 184.717 1.00 140.53 ? 89  TYR   A CD2 1 
ATOM   249  C  CE1 . TYR   A 1 40  ? 127.477 150.496 184.469 1.00 136.31 ? 89  TYR   A CE1 1 
ATOM   250  C  CE2 . TYR   A 1 40  ? 128.852 151.927 185.796 1.00 137.75 ? 89  TYR   A CE2 1 
ATOM   251  C  CZ  . TYR   A 1 40  ? 127.748 151.116 185.668 1.00 137.08 ? 89  TYR   A CZ  1 
ATOM   252  O  OH  . TYR   A 1 40  ? 126.913 150.924 186.743 1.00 137.87 ? 89  TYR   A OH  1 
ATOM   253  N  N   . GLU   A 1 41  ? 129.644 154.717 182.000 1.00 146.35 ? 90  GLU   A N   1 
ATOM   254  C  CA  . GLU   A 1 41  ? 128.967 155.931 182.452 1.00 148.57 ? 90  GLU   A CA  1 
ATOM   255  C  C   . GLU   A 1 41  ? 128.045 156.499 181.381 1.00 152.45 ? 90  GLU   A C   1 
ATOM   256  O  O   . GLU   A 1 41  ? 127.000 157.075 181.706 1.00 152.49 ? 90  GLU   A O   1 
ATOM   257  C  CB  . GLU   A 1 41  ? 129.974 157.005 182.875 1.00 148.79 ? 90  GLU   A CB  1 
ATOM   258  C  CG  . GLU   A 1 41  ? 131.162 156.529 183.689 1.00 151.58 ? 90  GLU   A CG  1 
ATOM   259  C  CD  . GLU   A 1 41  ? 130.764 155.674 184.875 1.00 155.04 ? 90  GLU   A CD  1 
ATOM   260  O  OE1 . GLU   A 1 41  ? 129.833 156.067 185.609 1.00 155.24 ? 90  GLU   A OE1 1 
ATOM   261  O  OE2 . GLU   A 1 41  ? 131.396 154.617 185.082 1.00 153.89 ? 90  GLU   A OE2 1 
ATOM   262  N  N   . LYS   A 1 42  ? 128.404 156.346 180.107 1.00 146.12 ? 91  LYS   A N   1 
ATOM   263  C  CA  . LYS   A 1 42  ? 127.637 156.982 179.043 1.00 144.18 ? 91  LYS   A CA  1 
ATOM   264  C  C   . LYS   A 1 42  ? 126.504 156.120 178.497 1.00 142.92 ? 91  LYS   A C   1 
ATOM   265  O  O   . LYS   A 1 42  ? 125.485 156.668 178.062 1.00 142.47 ? 91  LYS   A O   1 
ATOM   266  C  CB  . LYS   A 1 42  ? 128.570 157.384 177.898 1.00 140.32 ? 91  LYS   A CB  1 
ATOM   267  C  CG  . LYS   A 1 42  ? 129.368 158.645 178.177 1.00 140.36 ? 91  LYS   A CG  1 
ATOM   268  C  CD  . LYS   A 1 42  ? 130.635 158.700 177.342 1.00 142.80 ? 91  LYS   A CD  1 
ATOM   269  C  CE  . LYS   A 1 42  ? 131.610 159.726 177.895 1.00 141.93 ? 91  LYS   A CE  1 
ATOM   270  N  NZ  . LYS   A 1 42  ? 132.718 160.016 176.944 1.00 144.20 ? 91  LYS   A NZ  1 
ATOM   271  N  N   . TYR   A 1 43  ? 126.639 154.789 178.505 1.00 135.77 ? 92  TYR   A N   1 
ATOM   272  C  CA  . TYR   A 1 43  ? 125.654 153.926 177.860 1.00 134.93 ? 92  TYR   A CA  1 
ATOM   273  C  C   . TYR   A 1 43  ? 125.167 152.799 178.766 1.00 135.80 ? 92  TYR   A C   1 
ATOM   274  O  O   . TYR   A 1 43  ? 124.646 151.799 178.264 1.00 133.42 ? 92  TYR   A O   1 
ATOM   275  C  CB  . TYR   A 1 43  ? 126.218 153.333 176.567 1.00 132.99 ? 92  TYR   A CB  1 
ATOM   276  C  CG  . TYR   A 1 43  ? 126.806 154.349 175.617 1.00 137.06 ? 92  TYR   A CG  1 
ATOM   277  C  CD1 . TYR   A 1 43  ? 126.013 154.983 174.670 1.00 140.46 ? 92  TYR   A CD1 1 
ATOM   278  C  CD2 . TYR   A 1 43  ? 128.157 154.664 175.657 1.00 137.69 ? 92  TYR   A CD2 1 
ATOM   279  C  CE1 . TYR   A 1 43  ? 126.548 155.909 173.796 1.00 142.27 ? 92  TYR   A CE1 1 
ATOM   280  C  CE2 . TYR   A 1 43  ? 128.700 155.589 174.787 1.00 139.69 ? 92  TYR   A CE2 1 
ATOM   281  C  CZ  . TYR   A 1 43  ? 127.892 156.208 173.859 1.00 143.44 ? 92  TYR   A CZ  1 
ATOM   282  O  OH  . TYR   A 1 43  ? 128.429 157.130 172.990 1.00 141.52 ? 92  TYR   A OH  1 
ATOM   283  N  N   . GLY   A 1 44  ? 125.316 152.928 180.081 1.00 130.98 ? 93  GLY   A N   1 
ATOM   284  C  CA  . GLY   A 1 44  ? 124.823 151.918 180.985 1.00 126.61 ? 93  GLY   A CA  1 
ATOM   285  C  C   . GLY   A 1 44  ? 125.726 150.703 181.051 1.00 130.50 ? 93  GLY   A C   1 
ATOM   286  O  O   . GLY   A 1 44  ? 126.887 150.738 180.634 1.00 129.37 ? 93  GLY   A O   1 
ATOM   287  N  N   . PRO   A 1 45  ? 125.201 149.595 181.581 1.00 114.38 ? 94  PRO   A N   1 
ATOM   288  C  CA  . PRO   A 1 45  ? 126.033 148.410 181.824 1.00 105.92 ? 94  PRO   A CA  1 
ATOM   289  C  C   . PRO   A 1 45  ? 126.198 147.452 180.654 1.00 108.86 ? 94  PRO   A C   1 
ATOM   290  O  O   . PRO   A 1 45  ? 127.047 146.555 180.747 1.00 111.82 ? 94  PRO   A O   1 
ATOM   291  C  CB  . PRO   A 1 45  ? 125.286 147.702 182.976 1.00 101.13 ? 94  PRO   A CB  1 
ATOM   292  C  CG  . PRO   A 1 45  ? 124.198 148.655 183.416 1.00 107.59 ? 94  PRO   A CG  1 
ATOM   293  C  CD  . PRO   A 1 45  ? 123.882 149.467 182.214 1.00 113.86 ? 94  PRO   A CD  1 
ATOM   294  N  N   . VAL   A 1 46  ? 125.432 147.594 179.573 1.00 102.13 ? 95  VAL   A N   1 
ATOM   295  C  CA  . VAL   A 1 46  ? 125.429 146.585 178.518 1.00 90.88  ? 95  VAL   A CA  1 
ATOM   296  C  C   . VAL   A 1 46  ? 125.892 147.209 177.204 1.00 85.46  ? 95  VAL   A C   1 
ATOM   297  O  O   . VAL   A 1 46  ? 125.426 146.833 176.123 1.00 91.21  ? 95  VAL   A O   1 
ATOM   298  C  CB  . VAL   A 1 46  ? 124.035 145.944 178.375 1.00 93.14  ? 95  VAL   A CB  1 
ATOM   299  C  CG1 . VAL   A 1 46  ? 124.120 144.602 177.653 1.00 96.33  ? 95  VAL   A CG1 1 
ATOM   300  C  CG2 . VAL   A 1 46  ? 123.380 145.781 179.735 1.00 95.90  ? 95  VAL   A CG2 1 
ATOM   301  N  N   . PHE   A 1 47  ? 126.802 148.175 177.286 1.00 93.90  ? 96  PHE   A N   1 
ATOM   302  C  CA  . PHE   A 1 47  ? 127.293 148.833 176.082 1.00 103.28 ? 96  PHE   A CA  1 
ATOM   303  C  C   . PHE   A 1 47  ? 128.077 147.856 175.216 1.00 100.68 ? 96  PHE   A C   1 
ATOM   304  O  O   . PHE   A 1 47  ? 128.840 147.028 175.718 1.00 114.94 ? 96  PHE   A O   1 
ATOM   305  C  CB  . PHE   A 1 47  ? 128.172 150.027 176.449 1.00 115.60 ? 96  PHE   A CB  1 
ATOM   306  C  CG  . PHE   A 1 47  ? 129.336 149.678 177.330 1.00 109.51 ? 96  PHE   A CG  1 
ATOM   307  C  CD1 . PHE   A 1 47  ? 129.186 149.604 178.703 1.00 110.41 ? 96  PHE   A CD1 1 
ATOM   308  C  CD2 . PHE   A 1 47  ? 130.582 149.432 176.786 1.00 107.61 ? 96  PHE   A CD2 1 
ATOM   309  C  CE1 . PHE   A 1 47  ? 130.255 149.287 179.513 1.00 114.96 ? 96  PHE   A CE1 1 
ATOM   310  C  CE2 . PHE   A 1 47  ? 131.654 149.115 177.593 1.00 114.94 ? 96  PHE   A CE2 1 
ATOM   311  C  CZ  . PHE   A 1 47  ? 131.491 149.043 178.957 1.00 114.82 ? 96  PHE   A CZ  1 
ATOM   312  N  N   . SER   A 1 48  ? 127.888 147.959 173.904 1.00 106.71 ? 97  SER   A N   1 
ATOM   313  C  CA  . SER   A 1 48  ? 128.538 147.090 172.935 1.00 110.02 ? 97  SER   A CA  1 
ATOM   314  C  C   . SER   A 1 48  ? 129.670 147.828 172.233 1.00 111.82 ? 97  SER   A C   1 
ATOM   315  O  O   . SER   A 1 48  ? 129.826 149.045 172.356 1.00 117.27 ? 97  SER   A O   1 
ATOM   316  C  CB  . SER   A 1 48  ? 127.526 146.567 171.911 1.00 111.71 ? 97  SER   A CB  1 
ATOM   317  O  OG  . SER   A 1 48  ? 126.533 145.781 172.543 1.00 114.96 ? 97  SER   A OG  1 
ATOM   318  N  N   . PHE   A 1 49  ? 130.466 147.068 171.491 1.00 133.38 ? 98  PHE   A N   1 
ATOM   319  C  CA  . PHE   A 1 49  ? 131.653 147.564 170.806 1.00 131.85 ? 98  PHE   A CA  1 
ATOM   320  C  C   . PHE   A 1 49  ? 131.540 147.305 169.306 1.00 136.35 ? 98  PHE   A C   1 
ATOM   321  O  O   . PHE   A 1 49  ? 130.521 146.823 168.805 1.00 142.07 ? 98  PHE   A O   1 
ATOM   322  C  CB  . PHE   A 1 49  ? 132.918 146.889 171.341 1.00 138.69 ? 98  PHE   A CB  1 
ATOM   323  C  CG  . PHE   A 1 49  ? 133.462 147.491 172.600 1.00 137.00 ? 98  PHE   A CG  1 
ATOM   324  C  CD1 . PHE   A 1 49  ? 132.653 148.206 173.459 1.00 135.19 ? 98  PHE   A CD1 1 
ATOM   325  C  CD2 . PHE   A 1 49  ? 134.792 147.310 172.936 1.00 136.29 ? 98  PHE   A CD2 1 
ATOM   326  C  CE1 . PHE   A 1 49  ? 133.162 148.744 174.617 1.00 137.22 ? 98  PHE   A CE1 1 
ATOM   327  C  CE2 . PHE   A 1 49  ? 135.304 147.845 174.092 1.00 137.33 ? 98  PHE   A CE2 1 
ATOM   328  C  CZ  . PHE   A 1 49  ? 134.488 148.557 174.937 1.00 138.24 ? 98  PHE   A CZ  1 
ATOM   329  N  N   . THR   A 1 50  ? 132.615 147.637 168.593 1.00 144.07 ? 99  THR   A N   1 
ATOM   330  C  CA  . THR   A 1 50  ? 132.855 147.134 167.241 1.00 147.62 ? 99  THR   A CA  1 
ATOM   331  C  C   . THR   A 1 50  ? 134.369 147.127 167.062 1.00 149.24 ? 99  THR   A C   1 
ATOM   332  O  O   . THR   A 1 50  ? 134.964 148.169 166.776 1.00 151.65 ? 99  THR   A O   1 
ATOM   333  C  CB  . THR   A 1 50  ? 132.174 147.987 166.180 1.00 149.29 ? 99  THR   A CB  1 
ATOM   334  O  OG1 . THR   A 1 50  ? 130.858 148.341 166.614 1.00 152.01 ? 99  THR   A OG1 1 
ATOM   335  C  CG2 . THR   A 1 50  ? 132.074 147.221 164.870 1.00 147.15 ? 99  THR   A CG2 1 
ATOM   336  N  N   . MET   A 1 51  ? 134.986 145.962 167.244 1.00 143.96 ? 100 MET   A N   1 
ATOM   337  C  CA  . MET   A 1 51  ? 136.439 145.841 167.204 1.00 144.10 ? 100 MET   A CA  1 
ATOM   338  C  C   . MET   A 1 51  ? 136.821 144.749 166.216 1.00 145.04 ? 100 MET   A C   1 
ATOM   339  O  O   . MET   A 1 51  ? 136.591 143.563 166.479 1.00 148.34 ? 100 MET   A O   1 
ATOM   340  C  CB  . MET   A 1 51  ? 137.005 145.545 168.593 1.00 144.23 ? 100 MET   A CB  1 
ATOM   341  C  CG  . MET   A 1 51  ? 137.126 146.775 169.478 1.00 148.48 ? 100 MET   A CG  1 
ATOM   342  S  SD  . MET   A 1 51  ? 138.487 146.689 170.657 1.00 145.82 ? 100 MET   A SD  1 
ATOM   343  C  CE  . MET   A 1 51  ? 138.831 144.933 170.663 1.00 147.25 ? 100 MET   A CE  1 
ATOM   344  N  N   . VAL   A 1 52  ? 137.404 145.156 165.088 1.00 144.89 ? 101 VAL   A N   1 
ATOM   345  C  CA  . VAL   A 1 52  ? 137.962 144.251 164.088 1.00 145.00 ? 101 VAL   A CA  1 
ATOM   346  C  C   . VAL   A 1 52  ? 136.873 143.274 163.649 1.00 145.45 ? 101 VAL   A C   1 
ATOM   347  O  O   . VAL   A 1 52  ? 137.041 142.051 163.717 1.00 146.83 ? 101 VAL   A O   1 
ATOM   348  C  CB  . VAL   A 1 52  ? 139.212 143.534 164.639 1.00 143.49 ? 101 VAL   A CB  1 
ATOM   349  C  CG1 . VAL   A 1 52  ? 139.895 142.680 163.568 1.00 145.13 ? 101 VAL   A CG1 1 
ATOM   350  C  CG2 . VAL   A 1 52  ? 140.186 144.547 165.226 1.00 137.45 ? 101 VAL   A CG2 1 
ATOM   351  N  N   . GLY   A 1 53  ? 135.726 143.810 163.240 1.00 145.02 ? 102 GLY   A N   1 
ATOM   352  C  CA  . GLY   A 1 53  ? 134.668 142.978 162.703 1.00 146.74 ? 102 GLY   A CA  1 
ATOM   353  C  C   . GLY   A 1 53  ? 133.900 142.159 163.714 1.00 151.98 ? 102 GLY   A C   1 
ATOM   354  O  O   . GLY   A 1 53  ? 133.106 141.302 163.315 1.00 152.42 ? 102 GLY   A O   1 
ATOM   355  N  N   . LYS   A 1 54  ? 134.108 142.388 165.010 1.00 147.21 ? 103 LYS   A N   1 
ATOM   356  C  CA  . LYS   A 1 54  ? 133.415 141.650 166.056 1.00 142.01 ? 103 LYS   A CA  1 
ATOM   357  C  C   . LYS   A 1 54  ? 132.736 142.624 167.007 1.00 142.10 ? 103 LYS   A C   1 
ATOM   358  O  O   . LYS   A 1 54  ? 133.255 143.712 167.270 1.00 143.40 ? 103 LYS   A O   1 
ATOM   359  C  CB  . LYS   A 1 54  ? 134.376 140.744 166.834 1.00 136.39 ? 103 LYS   A CB  1 
ATOM   360  C  CG  . LYS   A 1 54  ? 135.319 139.939 165.958 1.00 140.21 ? 103 LYS   A CG  1 
ATOM   361  C  CD  . LYS   A 1 54  ? 136.655 139.714 166.645 1.00 142.70 ? 103 LYS   A CD  1 
ATOM   362  C  CE  . LYS   A 1 54  ? 137.736 139.348 165.641 1.00 145.04 ? 103 LYS   A CE  1 
ATOM   363  N  NZ  . LYS   A 1 54  ? 137.272 138.305 164.684 1.00 143.84 ? 103 LYS   A NZ  1 
ATOM   364  N  N   . THR   A 1 55  ? 131.574 142.225 167.518 1.00 126.37 ? 104 THR   A N   1 
ATOM   365  C  CA  . THR   A 1 55  ? 130.798 143.033 168.453 1.00 128.51 ? 104 THR   A CA  1 
ATOM   366  C  C   . THR   A 1 55  ? 131.102 142.556 169.869 1.00 130.10 ? 104 THR   A C   1 
ATOM   367  O  O   . THR   A 1 55  ? 130.690 141.460 170.263 1.00 137.94 ? 104 THR   A O   1 
ATOM   368  C  CB  . THR   A 1 55  ? 129.306 142.929 168.148 1.00 131.18 ? 104 THR   A CB  1 
ATOM   369  O  OG1 . THR   A 1 55  ? 129.110 142.885 166.729 1.00 127.60 ? 104 THR   A OG1 1 
ATOM   370  C  CG2 . THR   A 1 55  ? 128.561 144.127 168.715 1.00 129.62 ? 104 THR   A CG2 1 
ATOM   371  N  N   . PHE   A 1 56  ? 131.819 143.378 170.633 1.00 113.96 ? 105 PHE   A N   1 
ATOM   372  C  CA  . PHE   A 1 56  ? 132.250 143.013 171.982 1.00 114.51 ? 105 PHE   A CA  1 
ATOM   373  C  C   . PHE   A 1 56  ? 131.213 143.526 172.973 1.00 125.75 ? 105 PHE   A C   1 
ATOM   374  O  O   . PHE   A 1 56  ? 131.331 144.625 173.514 1.00 137.62 ? 105 PHE   A O   1 
ATOM   375  C  CB  . PHE   A 1 56  ? 133.630 143.585 172.278 1.00 114.78 ? 105 PHE   A CB  1 
ATOM   376  C  CG  . PHE   A 1 56  ? 134.764 142.746 171.764 1.00 128.60 ? 105 PHE   A CG  1 
ATOM   377  C  CD1 . PHE   A 1 56  ? 134.622 141.985 170.617 1.00 134.35 ? 105 PHE   A CD1 1 
ATOM   378  C  CD2 . PHE   A 1 56  ? 135.980 142.730 172.425 1.00 129.61 ? 105 PHE   A CD2 1 
ATOM   379  C  CE1 . PHE   A 1 56  ? 135.669 141.219 170.144 1.00 130.95 ? 105 PHE   A CE1 1 
ATOM   380  C  CE2 . PHE   A 1 56  ? 137.029 141.967 171.957 1.00 127.19 ? 105 PHE   A CE2 1 
ATOM   381  C  CZ  . PHE   A 1 56  ? 136.873 141.210 170.815 1.00 129.27 ? 105 PHE   A CZ  1 
ATOM   382  N  N   . THR   A 1 57  ? 130.189 142.714 173.226 1.00 106.48 ? 106 THR   A N   1 
ATOM   383  C  CA  . THR   A 1 57  ? 129.087 143.101 174.108 1.00 97.32  ? 106 THR   A CA  1 
ATOM   384  C  C   . THR   A 1 57  ? 129.538 142.949 175.554 1.00 92.90  ? 106 THR   A C   1 
ATOM   385  O  O   . THR   A 1 57  ? 129.331 141.914 176.186 1.00 113.13 ? 106 THR   A O   1 
ATOM   386  C  CB  . THR   A 1 57  ? 127.849 142.262 173.823 1.00 98.53  ? 106 THR   A CB  1 
ATOM   387  O  OG1 . THR   A 1 57  ? 127.637 142.186 172.409 1.00 109.70 ? 106 THR   A OG1 1 
ATOM   388  C  CG2 . THR   A 1 57  ? 126.630 142.878 174.481 1.00 98.07  ? 106 THR   A CG2 1 
ATOM   389  N  N   . TYR   A 1 58  ? 130.153 143.998 176.089 1.00 85.80  ? 107 TYR   A N   1 
ATOM   390  C  CA  . TYR   A 1 58  ? 130.639 143.962 177.461 1.00 88.30  ? 107 TYR   A CA  1 
ATOM   391  C  C   . TYR   A 1 58  ? 129.489 144.045 178.456 1.00 97.61  ? 107 TYR   A C   1 
ATOM   392  O  O   . TYR   A 1 58  ? 128.478 144.710 178.222 1.00 118.34 ? 107 TYR   A O   1 
ATOM   393  C  CB  . TYR   A 1 58  ? 131.620 145.103 177.710 1.00 97.17  ? 107 TYR   A CB  1 
ATOM   394  C  CG  . TYR   A 1 58  ? 133.021 144.786 177.262 1.00 106.59 ? 107 TYR   A CG  1 
ATOM   395  C  CD1 . TYR   A 1 58  ? 133.374 144.870 175.925 1.00 108.02 ? 107 TYR   A CD1 1 
ATOM   396  C  CD2 . TYR   A 1 58  ? 133.988 144.387 178.173 1.00 110.34 ? 107 TYR   A CD2 1 
ATOM   397  C  CE1 . TYR   A 1 58  ? 134.652 144.575 175.506 1.00 110.80 ? 107 TYR   A CE1 1 
ATOM   398  C  CE2 . TYR   A 1 58  ? 135.270 144.089 177.763 1.00 111.96 ? 107 TYR   A CE2 1 
ATOM   399  C  CZ  . TYR   A 1 58  ? 135.595 144.184 176.428 1.00 113.14 ? 107 TYR   A CZ  1 
ATOM   400  O  OH  . TYR   A 1 58  ? 136.869 143.889 176.006 1.00 117.21 ? 107 TYR   A OH  1 
ATOM   401  N  N   . LEU   A 1 59  ? 129.656 143.356 179.582 1.00 85.52  ? 108 LEU   A N   1 
ATOM   402  C  CA  . LEU   A 1 59  ? 128.694 143.366 180.681 1.00 86.25  ? 108 LEU   A CA  1 
ATOM   403  C  C   . LEU   A 1 59  ? 129.418 143.854 181.931 1.00 101.67 ? 108 LEU   A C   1 
ATOM   404  O  O   . LEU   A 1 59  ? 130.194 143.108 182.535 1.00 109.70 ? 108 LEU   A O   1 
ATOM   405  C  CB  . LEU   A 1 59  ? 128.088 141.984 180.900 1.00 74.09  ? 108 LEU   A CB  1 
ATOM   406  C  CG  . LEU   A 1 59  ? 127.555 141.249 179.673 1.00 93.12  ? 108 LEU   A CG  1 
ATOM   407  C  CD1 . LEU   A 1 59  ? 127.240 139.807 180.023 1.00 102.58 ? 108 LEU   A CD1 1 
ATOM   408  C  CD2 . LEU   A 1 59  ? 126.326 141.951 179.131 1.00 98.58  ? 108 LEU   A CD2 1 
ATOM   409  N  N   . LEU   A 1 60  ? 129.166 145.099 182.318 1.00 101.06 ? 109 LEU   A N   1 
ATOM   410  C  CA  . LEU   A 1 60  ? 129.770 145.682 183.505 1.00 93.22  ? 109 LEU   A CA  1 
ATOM   411  C  C   . LEU   A 1 60  ? 128.757 145.734 184.641 1.00 102.41 ? 109 LEU   A C   1 
ATOM   412  O  O   . LEU   A 1 60  ? 127.564 145.958 184.426 1.00 105.58 ? 109 LEU   A O   1 
ATOM   413  C  CB  . LEU   A 1 60  ? 130.304 147.083 183.213 1.00 99.40  ? 109 LEU   A CB  1 
ATOM   414  C  CG  . LEU   A 1 60  ? 131.492 147.139 182.253 1.00 98.82  ? 109 LEU   A CG  1 
ATOM   415  C  CD1 . LEU   A 1 60  ? 132.207 148.469 182.375 1.00 105.61 ? 109 LEU   A CD1 1 
ATOM   416  C  CD2 . LEU   A 1 60  ? 132.449 145.991 182.516 1.00 95.64  ? 109 LEU   A CD2 1 
ATOM   417  N  N   . GLY   A 1 61  ? 129.246 145.523 185.855 1.00 111.42 ? 110 GLY   A N   1 
ATOM   418  C  CA  . GLY   A 1 61  ? 128.391 145.460 187.018 1.00 111.40 ? 110 GLY   A CA  1 
ATOM   419  C  C   . GLY   A 1 61  ? 128.000 144.031 187.362 1.00 113.42 ? 110 GLY   A C   1 
ATOM   420  O  O   . GLY   A 1 61  ? 128.062 143.117 186.537 1.00 115.27 ? 110 GLY   A O   1 
ATOM   421  N  N   . SER   A 1 62  ? 127.593 143.843 188.619 1.00 121.38 ? 111 SER   A N   1 
ATOM   422  C  CA  . SER   A 1 62  ? 127.241 142.508 189.090 1.00 120.90 ? 111 SER   A CA  1 
ATOM   423  C  C   . SER   A 1 62  ? 126.037 141.949 188.342 1.00 129.60 ? 111 SER   A C   1 
ATOM   424  O  O   . SER   A 1 62  ? 126.042 140.785 187.921 1.00 130.67 ? 111 SER   A O   1 
ATOM   425  C  CB  . SER   A 1 62  ? 126.967 142.544 190.593 1.00 118.78 ? 111 SER   A CB  1 
ATOM   426  O  OG  . SER   A 1 62  ? 126.156 141.452 190.988 1.00 127.41 ? 111 SER   A OG  1 
ATOM   427  N  N   . ASP   A 1 63  ? 124.997 142.766 188.160 1.00 140.91 ? 112 ASP   A N   1 
ATOM   428  C  CA  . ASP   A 1 63  ? 123.780 142.284 187.515 1.00 137.24 ? 112 ASP   A CA  1 
ATOM   429  C  C   . ASP   A 1 63  ? 124.046 141.856 186.078 1.00 136.33 ? 112 ASP   A C   1 
ATOM   430  O  O   . ASP   A 1 63  ? 123.524 140.834 185.619 1.00 136.74 ? 112 ASP   A O   1 
ATOM   431  C  CB  . ASP   A 1 63  ? 122.698 143.363 187.564 1.00 137.35 ? 112 ASP   A CB  1 
ATOM   432  C  CG  . ASP   A 1 63  ? 122.469 143.896 188.965 1.00 139.72 ? 112 ASP   A CG  1 
ATOM   433  O  OD1 . ASP   A 1 63  ? 123.237 144.780 189.400 1.00 135.62 ? 112 ASP   A OD1 1 
ATOM   434  O  OD2 . ASP   A 1 63  ? 121.521 143.433 189.631 1.00 144.95 ? 112 ASP   A OD2 1 
ATOM   435  N  N   . ALA   A 1 64  ? 124.853 142.628 185.349 1.00 116.18 ? 113 ALA   A N   1 
ATOM   436  C  CA  . ALA   A 1 64  ? 125.157 142.274 183.968 1.00 107.87 ? 113 ALA   A CA  1 
ATOM   437  C  C   . ALA   A 1 64  ? 126.099 141.079 183.894 1.00 121.12 ? 113 ALA   A C   1 
ATOM   438  O  O   . ALA   A 1 64  ? 125.924 140.197 183.045 1.00 133.16 ? 113 ALA   A O   1 
ATOM   439  C  CB  . ALA   A 1 64  ? 125.753 143.476 183.238 1.00 112.81 ? 113 ALA   A CB  1 
ATOM   440  N  N   . ALA   A 1 65  ? 127.101 141.028 184.774 1.00 116.14 ? 114 ALA   A N   1 
ATOM   441  C  CA  . ALA   A 1 65  ? 128.081 139.949 184.730 1.00 107.49 ? 114 ALA   A CA  1 
ATOM   442  C  C   . ALA   A 1 65  ? 127.523 138.631 185.244 1.00 104.10 ? 114 ALA   A C   1 
ATOM   443  O  O   . ALA   A 1 65  ? 128.152 137.585 185.035 1.00 112.97 ? 114 ALA   A O   1 
ATOM   444  C  CB  . ALA   A 1 65  ? 129.320 140.334 185.537 1.00 104.45 ? 114 ALA   A CB  1 
ATOM   445  N  N   . ALA   A 1 66  ? 126.379 138.660 185.933 1.00 108.54 ? 115 ALA   A N   1 
ATOM   446  C  CA  . ALA   A 1 66  ? 125.772 137.419 186.399 1.00 116.24 ? 115 ALA   A CA  1 
ATOM   447  C  C   . ALA   A 1 66  ? 125.454 136.480 185.245 1.00 115.68 ? 115 ALA   A C   1 
ATOM   448  O  O   . ALA   A 1 66  ? 125.571 135.259 185.392 1.00 117.25 ? 115 ALA   A O   1 
ATOM   449  C  CB  . ALA   A 1 66  ? 124.509 137.723 187.204 1.00 121.39 ? 115 ALA   A CB  1 
ATOM   450  N  N   . LEU   A 1 67  ? 125.060 137.024 184.092 1.00 107.99 ? 116 LEU   A N   1 
ATOM   451  C  CA  . LEU   A 1 67  ? 124.780 136.180 182.936 1.00 111.20 ? 116 LEU   A CA  1 
ATOM   452  C  C   . LEU   A 1 67  ? 126.011 135.379 182.534 1.00 117.87 ? 116 LEU   A C   1 
ATOM   453  O  O   . LEU   A 1 67  ? 125.936 134.162 182.331 1.00 123.67 ? 116 LEU   A O   1 
ATOM   454  C  CB  . LEU   A 1 67  ? 124.294 137.034 181.767 1.00 111.82 ? 116 LEU   A CB  1 
ATOM   455  C  CG  . LEU   A 1 67  ? 124.134 136.293 180.438 1.00 115.01 ? 116 LEU   A CG  1 
ATOM   456  C  CD1 . LEU   A 1 67  ? 123.172 135.125 180.587 1.00 117.41 ? 116 LEU   A CD1 1 
ATOM   457  C  CD2 . LEU   A 1 67  ? 123.672 137.238 179.342 1.00 119.09 ? 116 LEU   A CD2 1 
ATOM   458  N  N   . LEU   A 1 68  ? 127.161 136.046 182.424 1.00 102.66 ? 117 LEU   A N   1 
ATOM   459  C  CA  . LEU   A 1 68  ? 128.375 135.349 182.014 1.00 106.96 ? 117 LEU   A CA  1 
ATOM   460  C  C   . LEU   A 1 68  ? 128.859 134.393 183.095 1.00 100.16 ? 117 LEU   A C   1 
ATOM   461  O  O   . LEU   A 1 68  ? 129.362 133.307 182.788 1.00 95.64  ? 117 LEU   A O   1 
ATOM   462  C  CB  . LEU   A 1 68  ? 129.466 136.357 181.660 1.00 110.07 ? 117 LEU   A CB  1 
ATOM   463  C  CG  . LEU   A 1 68  ? 130.603 135.846 180.774 1.00 101.70 ? 117 LEU   A CG  1 
ATOM   464  C  CD1 . LEU   A 1 68  ? 131.058 136.938 179.826 1.00 106.03 ? 117 LEU   A CD1 1 
ATOM   465  C  CD2 . LEU   A 1 68  ? 131.766 135.349 181.613 1.00 102.22 ? 117 LEU   A CD2 1 
ATOM   466  N  N   . PHE   A 1 69  ? 128.721 134.774 184.365 1.00 109.48 ? 118 PHE   A N   1 
ATOM   467  C  CA  . PHE   A 1 69  ? 129.233 133.931 185.439 1.00 103.13 ? 118 PHE   A CA  1 
ATOM   468  C  C   . PHE   A 1 69  ? 128.307 132.775 185.793 1.00 110.94 ? 118 PHE   A C   1 
ATOM   469  O  O   . PHE   A 1 69  ? 128.729 131.874 186.526 1.00 109.13 ? 118 PHE   A O   1 
ATOM   470  C  CB  . PHE   A 1 69  ? 129.507 134.771 186.687 1.00 101.17 ? 118 PHE   A CB  1 
ATOM   471  C  CG  . PHE   A 1 69  ? 130.657 135.720 186.534 1.00 107.04 ? 118 PHE   A CG  1 
ATOM   472  C  CD1 . PHE   A 1 69  ? 131.819 135.319 185.903 1.00 106.04 ? 118 PHE   A CD1 1 
ATOM   473  C  CD2 . PHE   A 1 69  ? 130.579 137.011 187.023 1.00 114.78 ? 118 PHE   A CD2 1 
ATOM   474  C  CE1 . PHE   A 1 69  ? 132.880 136.188 185.760 1.00 104.89 ? 118 PHE   A CE1 1 
ATOM   475  C  CE2 . PHE   A 1 69  ? 131.637 137.883 186.882 1.00 110.20 ? 118 PHE   A CE2 1 
ATOM   476  C  CZ  . PHE   A 1 69  ? 132.789 137.471 186.250 1.00 104.68 ? 118 PHE   A CZ  1 
ATOM   477  N  N   . ASN   A 1 70  ? 127.067 132.776 185.305 1.00 126.75 ? 119 ASN   A N   1 
ATOM   478  C  CA  . ASN   A 1 70  ? 126.162 131.652 185.503 1.00 126.86 ? 119 ASN   A CA  1 
ATOM   479  C  C   . ASN   A 1 70  ? 125.792 130.948 184.207 1.00 126.57 ? 119 ASN   A C   1 
ATOM   480  O  O   . ASN   A 1 70  ? 125.007 129.994 184.243 1.00 128.03 ? 119 ASN   A O   1 
ATOM   481  C  CB  . ASN   A 1 70  ? 124.881 132.115 186.210 1.00 122.51 ? 119 ASN   A CB  1 
ATOM   482  C  CG  . ASN   A 1 70  ? 125.158 132.778 187.541 1.00 127.35 ? 119 ASN   A CG  1 
ATOM   483  O  OD1 . ASN   A 1 70  ? 126.086 132.400 188.254 1.00 130.78 ? 119 ASN   A OD1 1 
ATOM   484  N  ND2 . ASN   A 1 70  ? 124.352 133.776 187.883 1.00 128.95 ? 119 ASN   A ND2 1 
ATOM   485  N  N   . SER   A 1 71  ? 126.325 131.386 183.072 1.00 122.64 ? 120 SER   A N   1 
ATOM   486  C  CA  . SER   A 1 71  ? 125.957 130.800 181.795 1.00 124.41 ? 120 SER   A CA  1 
ATOM   487  C  C   . SER   A 1 71  ? 126.554 129.406 181.637 1.00 126.28 ? 120 SER   A C   1 
ATOM   488  O  O   . SER   A 1 71  ? 127.513 129.024 182.313 1.00 125.12 ? 120 SER   A O   1 
ATOM   489  C  CB  . SER   A 1 71  ? 126.421 131.695 180.648 1.00 127.70 ? 120 SER   A CB  1 
ATOM   490  O  OG  . SER   A 1 71  ? 127.789 132.029 180.799 1.00 132.47 ? 120 SER   A OG  1 
ATOM   491  N  N   . LYS   A 1 72  ? 125.968 128.645 180.720 1.00 140.04 ? 121 LYS   A N   1 
ATOM   492  C  CA  . LYS   A 1 72  ? 126.420 127.306 180.381 1.00 141.61 ? 121 LYS   A CA  1 
ATOM   493  C  C   . LYS   A 1 72  ? 127.220 127.339 179.085 1.00 143.28 ? 121 LYS   A C   1 
ATOM   494  O  O   . LYS   A 1 72  ? 127.062 128.235 178.253 1.00 142.27 ? 121 LYS   A O   1 
ATOM   495  C  CB  . LYS   A 1 72  ? 125.231 126.349 180.239 1.00 140.47 ? 121 LYS   A CB  1 
ATOM   496  C  CG  . LYS   A 1 72  ? 124.823 125.633 181.522 1.00 138.59 ? 121 LYS   A CG  1 
ATOM   497  C  CD  . LYS   A 1 72  ? 124.449 126.610 182.627 1.00 143.68 ? 121 LYS   A CD  1 
ATOM   498  C  CE  . LYS   A 1 72  ? 123.870 125.892 183.835 1.00 143.00 ? 121 LYS   A CE  1 
ATOM   499  N  NZ  . LYS   A 1 72  ? 123.010 126.791 184.654 1.00 136.40 ? 121 LYS   A NZ  1 
ATOM   500  N  N   . ASN   A 1 73  ? 128.094 126.343 178.923 1.00 148.74 ? 122 ASN   A N   1 
ATOM   501  C  CA  . ASN   A 1 73  ? 128.907 126.270 177.716 1.00 147.42 ? 122 ASN   A CA  1 
ATOM   502  C  C   . ASN   A 1 73  ? 128.067 126.056 176.466 1.00 147.21 ? 122 ASN   A C   1 
ATOM   503  O  O   . ASN   A 1 73  ? 128.519 126.393 175.367 1.00 151.57 ? 122 ASN   A O   1 
ATOM   504  C  CB  . ASN   A 1 73  ? 129.945 125.157 177.837 1.00 147.38 ? 122 ASN   A CB  1 
ATOM   505  C  CG  . ASN   A 1 73  ? 131.251 125.508 177.155 1.00 146.41 ? 122 ASN   A CG  1 
ATOM   506  O  OD1 . ASN   A 1 73  ? 131.683 124.826 176.227 1.00 144.85 ? 122 ASN   A OD1 1 
ATOM   507  N  ND2 . ASN   A 1 73  ? 131.885 126.580 177.612 1.00 144.46 ? 122 ASN   A ND2 1 
ATOM   508  N  N   . GLU   A 1 74  ? 126.862 125.502 176.605 1.00 152.63 ? 123 GLU   A N   1 
ATOM   509  C  CA  . GLU   A 1 74  ? 125.956 125.407 175.468 1.00 152.80 ? 123 GLU   A CA  1 
ATOM   510  C  C   . GLU   A 1 74  ? 125.439 126.772 175.034 1.00 157.94 ? 123 GLU   A C   1 
ATOM   511  O  O   . GLU   A 1 74  ? 124.990 126.916 173.892 1.00 158.74 ? 123 GLU   A O   1 
ATOM   512  C  CB  . GLU   A 1 74  ? 124.782 124.488 175.805 1.00 152.10 ? 123 GLU   A CB  1 
ATOM   513  C  CG  . GLU   A 1 74  ? 124.918 123.081 175.253 1.00 158.37 ? 123 GLU   A CG  1 
ATOM   514  C  CD  . GLU   A 1 74  ? 125.690 122.164 176.180 1.00 163.94 ? 123 GLU   A CD  1 
ATOM   515  O  OE1 . GLU   A 1 74  ? 126.062 122.611 177.285 1.00 164.46 ? 123 GLU   A OE1 1 
ATOM   516  O  OE2 . GLU   A 1 74  ? 125.923 120.996 175.805 1.00 163.75 ? 123 GLU   A OE2 1 
ATOM   517  N  N   . ASP   A 1 75  ? 125.492 127.770 175.915 1.00 150.75 ? 124 ASP   A N   1 
ATOM   518  C  CA  . ASP   A 1 75  ? 125.043 129.124 175.611 1.00 149.37 ? 124 ASP   A CA  1 
ATOM   519  C  C   . ASP   A 1 75  ? 126.202 130.079 175.354 1.00 145.26 ? 124 ASP   A C   1 
ATOM   520  O  O   . ASP   A 1 75  ? 126.247 130.732 174.309 1.00 144.10 ? 124 ASP   A O   1 
ATOM   521  C  CB  . ASP   A 1 75  ? 124.172 129.659 176.753 1.00 149.09 ? 124 ASP   A CB  1 
ATOM   522  C  CG  . ASP   A 1 75  ? 123.277 128.593 177.351 1.00 151.43 ? 124 ASP   A CG  1 
ATOM   523  O  OD1 . ASP   A 1 75  ? 122.741 127.766 176.584 1.00 154.42 ? 124 ASP   A OD1 1 
ATOM   524  O  OD2 . ASP   A 1 75  ? 123.107 128.582 178.588 1.00 148.43 ? 124 ASP   A OD2 1 
ATOM   525  N  N   . LEU   A 1 76  ? 127.141 130.175 176.291 1.00 132.41 ? 125 LEU   A N   1 
ATOM   526  C  CA  . LEU   A 1 76  ? 128.326 131.019 176.152 1.00 134.93 ? 125 LEU   A CA  1 
ATOM   527  C  C   . LEU   A 1 76  ? 129.527 130.099 175.964 1.00 129.35 ? 125 LEU   A C   1 
ATOM   528  O  O   . LEU   A 1 76  ? 130.058 129.550 176.933 1.00 128.14 ? 125 LEU   A O   1 
ATOM   529  C  CB  . LEU   A 1 76  ? 128.496 131.931 177.362 1.00 129.80 ? 125 LEU   A CB  1 
ATOM   530  C  CG  . LEU   A 1 76  ? 127.644 133.202 177.362 1.00 124.33 ? 125 LEU   A CG  1 
ATOM   531  C  CD1 . LEU   A 1 76  ? 128.127 134.174 178.421 1.00 125.74 ? 125 LEU   A CD1 1 
ATOM   532  C  CD2 . LEU   A 1 76  ? 127.660 133.858 175.994 1.00 124.21 ? 125 LEU   A CD2 1 
ATOM   533  N  N   . ASN   A 1 77  ? 129.953 129.939 174.715 1.00 132.33 ? 126 ASN   A N   1 
ATOM   534  C  CA  . ASN   A 1 77  ? 131.005 128.992 174.359 1.00 134.68 ? 126 ASN   A CA  1 
ATOM   535  C  C   . ASN   A 1 77  ? 132.359 129.684 174.461 1.00 138.55 ? 126 ASN   A C   1 
ATOM   536  O  O   . ASN   A 1 77  ? 132.647 130.615 173.704 1.00 145.58 ? 126 ASN   A O   1 
ATOM   537  C  CB  . ASN   A 1 77  ? 130.772 128.446 172.953 1.00 132.63 ? 126 ASN   A CB  1 
ATOM   538  C  CG  . ASN   A 1 77  ? 131.571 127.192 172.677 1.00 138.11 ? 126 ASN   A CG  1 
ATOM   539  O  OD1 . ASN   A 1 77  ? 132.401 126.780 173.485 1.00 139.64 ? 126 ASN   A OD1 1 
ATOM   540  N  ND2 . ASN   A 1 77  ? 131.323 126.576 171.528 1.00 139.39 ? 126 ASN   A ND2 1 
ATOM   541  N  N   . ALA   A 1 78  ? 133.190 129.230 175.399 1.00 119.24 ? 127 ALA   A N   1 
ATOM   542  C  CA  . ALA   A 1 78  ? 134.541 129.764 175.520 1.00 112.25 ? 127 ALA   A CA  1 
ATOM   543  C  C   . ALA   A 1 78  ? 135.470 129.208 174.451 1.00 116.63 ? 127 ALA   A C   1 
ATOM   544  O  O   . ALA   A 1 78  ? 136.440 129.877 174.067 1.00 123.17 ? 127 ALA   A O   1 
ATOM   545  C  CB  . ALA   A 1 78  ? 135.104 129.463 176.908 1.00 112.04 ? 127 ALA   A CB  1 
ATOM   546  N  N   . GLU   A 1 79  ? 135.194 127.994 173.970 1.00 137.47 ? 128 GLU   A N   1 
ATOM   547  C  CA  . GLU   A 1 79  ? 136.072 127.366 172.990 1.00 142.06 ? 128 GLU   A CA  1 
ATOM   548  C  C   . GLU   A 1 79  ? 136.125 128.169 171.698 1.00 144.55 ? 128 GLU   A C   1 
ATOM   549  O  O   . GLU   A 1 79  ? 137.207 128.394 171.150 1.00 142.66 ? 128 GLU   A O   1 
ATOM   550  C  CB  . GLU   A 1 79  ? 135.616 125.934 172.717 1.00 139.25 ? 128 GLU   A CB  1 
ATOM   551  C  CG  . GLU   A 1 79  ? 135.819 124.990 173.889 1.00 140.95 ? 128 GLU   A CG  1 
ATOM   552  C  CD  . GLU   A 1 79  ? 134.571 124.202 174.224 1.00 145.56 ? 128 GLU   A CD  1 
ATOM   553  O  OE1 . GLU   A 1 79  ? 133.705 124.054 173.337 1.00 143.44 ? 128 GLU   A OE1 1 
ATOM   554  O  OE2 . GLU   A 1 79  ? 134.454 123.733 175.376 1.00 143.63 ? 128 GLU   A OE2 1 
ATOM   555  N  N   . ASP   A 1 80  ? 134.975 128.647 171.220 1.00 134.53 ? 129 ASP   A N   1 
ATOM   556  C  CA  . ASP   A 1 80  ? 134.953 129.384 169.961 1.00 132.93 ? 129 ASP   A CA  1 
ATOM   557  C  C   . ASP   A 1 80  ? 135.754 130.676 170.031 1.00 130.55 ? 129 ASP   A C   1 
ATOM   558  O  O   . ASP   A 1 80  ? 136.062 131.257 168.986 1.00 131.76 ? 129 ASP   A O   1 
ATOM   559  C  CB  . ASP   A 1 80  ? 133.513 129.681 169.547 1.00 131.28 ? 129 ASP   A CB  1 
ATOM   560  C  CG  . ASP   A 1 80  ? 132.903 128.560 168.732 1.00 140.00 ? 129 ASP   A CG  1 
ATOM   561  O  OD1 . ASP   A 1 80  ? 133.192 127.383 169.030 1.00 141.53 ? 129 ASP   A OD1 1 
ATOM   562  O  OD2 . ASP   A 1 80  ? 132.138 128.856 167.790 1.00 143.94 ? 129 ASP   A OD2 1 
ATOM   563  N  N   . VAL   A 1 81  ? 136.094 131.140 171.229 1.00 111.76 ? 130 VAL   A N   1 
ATOM   564  C  CA  . VAL   A 1 81  ? 136.947 132.307 171.395 1.00 112.81 ? 130 VAL   A CA  1 
ATOM   565  C  C   . VAL   A 1 81  ? 138.404 131.916 171.604 1.00 115.37 ? 130 VAL   A C   1 
ATOM   566  O  O   . VAL   A 1 81  ? 139.301 132.539 171.035 1.00 120.28 ? 130 VAL   A O   1 
ATOM   567  C  CB  . VAL   A 1 81  ? 136.444 133.185 172.560 1.00 115.94 ? 130 VAL   A CB  1 
ATOM   568  C  CG1 . VAL   A 1 81  ? 137.186 134.509 172.577 1.00 111.68 ? 130 VAL   A CG1 1 
ATOM   569  C  CG2 . VAL   A 1 81  ? 134.956 133.414 172.448 1.00 117.71 ? 130 VAL   A CG2 1 
ATOM   570  N  N   . TYR   A 1 82  ? 138.663 130.889 172.414 1.00 111.05 ? 131 TYR   A N   1 
ATOM   571  C  CA  . TYR   A 1 82  ? 140.014 130.623 172.891 1.00 110.25 ? 131 TYR   A CA  1 
ATOM   572  C  C   . TYR   A 1 82  ? 140.708 129.447 172.214 1.00 114.71 ? 131 TYR   A C   1 
ATOM   573  O  O   . TYR   A 1 82  ? 141.880 129.197 172.513 1.00 121.82 ? 131 TYR   A O   1 
ATOM   574  C  CB  . TYR   A 1 82  ? 139.994 130.385 174.404 1.00 109.12 ? 131 TYR   A CB  1 
ATOM   575  C  CG  . TYR   A 1 82  ? 139.755 131.631 175.221 1.00 109.29 ? 131 TYR   A CG  1 
ATOM   576  C  CD1 . TYR   A 1 82  ? 140.623 132.709 175.146 1.00 108.05 ? 131 TYR   A CD1 1 
ATOM   577  C  CD2 . TYR   A 1 82  ? 138.666 131.726 176.074 1.00 113.56 ? 131 TYR   A CD2 1 
ATOM   578  C  CE1 . TYR   A 1 82  ? 140.410 133.849 175.893 1.00 111.07 ? 131 TYR   A CE1 1 
ATOM   579  C  CE2 . TYR   A 1 82  ? 138.445 132.860 176.826 1.00 105.53 ? 131 TYR   A CE2 1 
ATOM   580  C  CZ  . TYR   A 1 82  ? 139.320 133.918 176.731 1.00 109.13 ? 131 TYR   A CZ  1 
ATOM   581  O  OH  . TYR   A 1 82  ? 139.105 135.052 177.478 1.00 122.44 ? 131 TYR   A OH  1 
ATOM   582  N  N   . SER   A 1 83  ? 140.036 128.717 171.321 1.00 112.10 ? 132 SER   A N   1 
ATOM   583  C  CA  . SER   A 1 83  ? 140.631 127.502 170.773 1.00 112.88 ? 132 SER   A CA  1 
ATOM   584  C  C   . SER   A 1 83  ? 141.804 127.824 169.859 1.00 115.22 ? 132 SER   A C   1 
ATOM   585  O  O   . SER   A 1 83  ? 142.891 127.254 170.005 1.00 115.08 ? 132 SER   A O   1 
ATOM   586  C  CB  . SER   A 1 83  ? 139.572 126.691 170.028 1.00 114.06 ? 132 SER   A CB  1 
ATOM   587  O  OG  . SER   A 1 83  ? 139.003 127.445 168.973 1.00 119.09 ? 132 SER   A OG  1 
ATOM   588  N  N   . ARG   A 1 84  ? 141.610 128.759 168.926 1.00 132.28 ? 133 ARG   A N   1 
ATOM   589  C  CA  . ARG   A 1 84  ? 142.654 129.083 167.962 1.00 128.79 ? 133 ARG   A CA  1 
ATOM   590  C  C   . ARG   A 1 84  ? 143.913 129.617 168.629 1.00 132.66 ? 133 ARG   A C   1 
ATOM   591  O  O   . ARG   A 1 84  ? 144.983 129.601 168.012 1.00 136.66 ? 133 ARG   A O   1 
ATOM   592  C  CB  . ARG   A 1 84  ? 142.130 130.097 166.945 1.00 128.47 ? 133 ARG   A CB  1 
ATOM   593  C  CG  . ARG   A 1 84  ? 141.237 131.168 167.544 1.00 128.50 ? 133 ARG   A CG  1 
ATOM   594  C  CD  . ARG   A 1 84  ? 140.614 132.035 166.465 1.00 134.54 ? 133 ARG   A CD  1 
ATOM   595  N  NE  . ARG   A 1 84  ? 141.624 132.714 165.662 1.00 139.86 ? 133 ARG   A NE  1 
ATOM   596  C  CZ  . ARG   A 1 84  ? 142.292 133.790 166.053 1.00 139.47 ? 133 ARG   A CZ  1 
ATOM   597  N  NH1 . ARG   A 1 84  ? 142.078 134.346 167.234 1.00 137.80 ? 133 ARG   A NH1 1 
ATOM   598  N  NH2 . ARG   A 1 84  ? 143.198 134.323 165.239 1.00 136.56 ? 133 ARG   A NH2 1 
ATOM   599  N  N   . LEU   A 1 85  ? 143.813 130.088 169.870 1.00 124.20 ? 134 LEU   A N   1 
ATOM   600  C  CA  . LEU   A 1 85  ? 144.989 130.546 170.595 1.00 120.81 ? 134 LEU   A CA  1 
ATOM   601  C  C   . LEU   A 1 85  ? 145.572 129.472 171.502 1.00 120.50 ? 134 LEU   A C   1 
ATOM   602  O  O   . LEU   A 1 85  ? 146.797 129.338 171.583 1.00 124.22 ? 134 LEU   A O   1 
ATOM   603  C  CB  . LEU   A 1 85  ? 144.661 131.788 171.425 1.00 122.53 ? 134 LEU   A CB  1 
ATOM   604  C  CG  . LEU   A 1 85  ? 144.230 133.062 170.699 1.00 128.43 ? 134 LEU   A CG  1 
ATOM   605  C  CD1 . LEU   A 1 85  ? 142.744 133.061 170.370 1.00 124.86 ? 134 LEU   A CD1 1 
ATOM   606  C  CD2 . LEU   A 1 85  ? 144.596 134.265 171.539 1.00 129.32 ? 134 LEU   A CD2 1 
ATOM   607  N  N   . THR   A 1 86  ? 144.729 128.698 172.187 1.00 121.17 ? 135 THR   A N   1 
ATOM   608  C  CA  . THR   A 1 86  ? 145.229 127.763 173.186 1.00 121.91 ? 135 THR   A CA  1 
ATOM   609  C  C   . THR   A 1 86  ? 145.629 126.412 172.611 1.00 121.39 ? 135 THR   A C   1 
ATOM   610  O  O   . THR   A 1 86  ? 146.543 125.776 173.147 1.00 126.29 ? 135 THR   A O   1 
ATOM   611  C  CB  . THR   A 1 86  ? 144.184 127.549 174.285 1.00 124.01 ? 135 THR   A CB  1 
ATOM   612  O  OG1 . THR   A 1 86  ? 142.981 127.025 173.710 1.00 132.38 ? 135 THR   A OG1 1 
ATOM   613  C  CG2 . THR   A 1 86  ? 143.883 128.858 174.999 1.00 121.04 ? 135 THR   A CG2 1 
ATOM   614  N  N   . THR   A 1 87  ? 144.971 125.943 171.550 1.00 114.38 ? 136 THR   A N   1 
ATOM   615  C  CA  . THR   A 1 87  ? 145.324 124.639 170.991 1.00 113.49 ? 136 THR   A CA  1 
ATOM   616  C  C   . THR   A 1 87  ? 146.761 124.577 170.483 1.00 114.44 ? 136 THR   A C   1 
ATOM   617  O  O   . THR   A 1 87  ? 147.490 123.657 170.892 1.00 120.14 ? 136 THR   A O   1 
ATOM   618  C  CB  . THR   A 1 87  ? 144.321 124.259 169.896 1.00 114.15 ? 136 THR   A CB  1 
ATOM   619  O  OG1 . THR   A 1 87  ? 143.100 123.815 170.500 1.00 113.09 ? 136 THR   A OG1 1 
ATOM   620  C  CG2 . THR   A 1 87  ? 144.879 123.150 169.022 1.00 111.71 ? 136 THR   A CG2 1 
ATOM   621  N  N   . PRO   A 1 88  ? 147.243 125.497 169.635 1.00 116.41 ? 137 PRO   A N   1 
ATOM   622  C  CA  . PRO   A 1 88  ? 148.624 125.356 169.140 1.00 121.89 ? 137 PRO   A CA  1 
ATOM   623  C  C   . PRO   A 1 88  ? 149.676 125.424 170.231 1.00 124.55 ? 137 PRO   A C   1 
ATOM   624  O  O   . PRO   A 1 88  ? 150.732 124.792 170.098 1.00 121.62 ? 137 PRO   A O   1 
ATOM   625  C  CB  . PRO   A 1 88  ? 148.779 126.518 168.148 1.00 123.90 ? 137 PRO   A CB  1 
ATOM   626  C  CG  . PRO   A 1 88  ? 147.670 127.435 168.406 1.00 116.75 ? 137 PRO   A CG  1 
ATOM   627  C  CD  . PRO   A 1 88  ? 146.577 126.691 169.084 1.00 121.43 ? 137 PRO   A CD  1 
ATOM   628  N  N   . VAL   A 1 89  ? 149.429 126.170 171.303 1.00 115.94 ? 138 VAL   A N   1 
ATOM   629  C  CA  . VAL   A 1 89  ? 150.441 126.353 172.339 1.00 111.76 ? 138 VAL   A CA  1 
ATOM   630  C  C   . VAL   A 1 89  ? 150.367 125.256 173.395 1.00 116.34 ? 138 VAL   A C   1 
ATOM   631  O  O   . VAL   A 1 89  ? 151.398 124.785 173.879 1.00 120.60 ? 138 VAL   A O   1 
ATOM   632  C  CB  . VAL   A 1 89  ? 150.306 127.757 172.962 1.00 110.20 ? 138 VAL   A CB  1 
ATOM   633  C  CG1 . VAL   A 1 89  ? 148.902 127.982 173.475 1.00 109.16 ? 138 VAL   A CG1 1 
ATOM   634  C  CG2 . VAL   A 1 89  ? 151.319 127.950 174.074 1.00 113.60 ? 138 VAL   A CG2 1 
ATOM   635  N  N   . PHE   A 1 90  ? 149.163 124.822 173.766 1.00 117.55 ? 139 PHE   A N   1 
ATOM   636  C  CA  . PHE   A 1 90  ? 149.021 123.791 174.786 1.00 110.20 ? 139 PHE   A CA  1 
ATOM   637  C  C   . PHE   A 1 90  ? 149.132 122.389 174.198 1.00 111.47 ? 139 PHE   A C   1 
ATOM   638  O  O   . PHE   A 1 90  ? 149.944 121.583 174.660 1.00 117.82 ? 139 PHE   A O   1 
ATOM   639  C  CB  . PHE   A 1 90  ? 147.685 123.955 175.517 1.00 109.10 ? 139 PHE   A CB  1 
ATOM   640  C  CG  . PHE   A 1 90  ? 147.629 125.159 176.411 1.00 115.24 ? 139 PHE   A CG  1 
ATOM   641  C  CD1 . PHE   A 1 90  ? 148.757 125.590 177.086 1.00 109.53 ? 139 PHE   A CD1 1 
ATOM   642  C  CD2 . PHE   A 1 90  ? 146.449 125.860 176.575 1.00 119.99 ? 139 PHE   A CD2 1 
ATOM   643  C  CE1 . PHE   A 1 90  ? 148.710 126.701 177.906 1.00 109.92 ? 139 PHE   A CE1 1 
ATOM   644  C  CE2 . PHE   A 1 90  ? 146.395 126.970 177.395 1.00 117.53 ? 139 PHE   A CE2 1 
ATOM   645  C  CZ  . PHE   A 1 90  ? 147.527 127.389 178.062 1.00 114.94 ? 139 PHE   A CZ  1 
ATOM   646  N  N   . GLY   A 1 91  ? 148.335 122.085 173.189 1.00 114.73 ? 140 GLY   A N   1 
ATOM   647  C  CA  . GLY   A 1 91  ? 148.352 120.769 172.582 1.00 115.55 ? 140 GLY   A CA  1 
ATOM   648  C  C   . GLY   A 1 91  ? 146.997 120.427 172.004 1.00 121.97 ? 140 GLY   A C   1 
ATOM   649  O  O   . GLY   A 1 91  ? 146.034 121.182 172.112 1.00 126.23 ? 140 GLY   A O   1 
ATOM   650  N  N   . LYS   A 1 92  ? 146.939 119.258 171.378 1.00 132.81 ? 141 LYS   A N   1 
ATOM   651  C  CA  . LYS   A 1 92  ? 145.711 118.746 170.789 1.00 132.88 ? 141 LYS   A CA  1 
ATOM   652  C  C   . LYS   A 1 92  ? 145.099 117.699 171.708 1.00 134.22 ? 141 LYS   A C   1 
ATOM   653  O  O   . LYS   A 1 92  ? 145.806 116.846 172.253 1.00 138.30 ? 141 LYS   A O   1 
ATOM   654  C  CB  . LYS   A 1 92  ? 145.974 118.148 169.406 1.00 135.23 ? 141 LYS   A CB  1 
ATOM   655  C  CG  . LYS   A 1 92  ? 144.728 117.631 168.707 1.00 136.05 ? 141 LYS   A CG  1 
ATOM   656  C  CD  . LYS   A 1 92  ? 144.780 117.898 167.212 1.00 138.44 ? 141 LYS   A CD  1 
ATOM   657  C  CE  . LYS   A 1 92  ? 144.929 119.383 166.922 1.00 139.24 ? 141 LYS   A CE  1 
ATOM   658  N  NZ  . LYS   A 1 92  ? 143.724 120.152 167.336 1.00 139.06 ? 141 LYS   A NZ  1 
ATOM   659  N  N   . GLY   A 1 93  ? 143.782 117.769 171.878 1.00 135.04 ? 142 GLY   A N   1 
ATOM   660  C  CA  . GLY   A 1 93  ? 143.097 116.884 172.795 1.00 136.62 ? 142 GLY   A CA  1 
ATOM   661  C  C   . GLY   A 1 93  ? 143.134 117.320 174.240 1.00 135.36 ? 142 GLY   A C   1 
ATOM   662  O  O   . GLY   A 1 93  ? 142.756 116.537 175.118 1.00 137.34 ? 142 GLY   A O   1 
ATOM   663  N  N   . VAL   A 1 94  ? 143.588 118.542 174.518 1.00 132.41 ? 143 VAL   A N   1 
ATOM   664  C  CA  . VAL   A 1 94  ? 143.683 119.062 175.874 1.00 129.93 ? 143 VAL   A CA  1 
ATOM   665  C  C   . VAL   A 1 94  ? 143.224 120.513 175.860 1.00 131.10 ? 143 VAL   A C   1 
ATOM   666  O  O   . VAL   A 1 94  ? 143.107 121.140 174.805 1.00 139.66 ? 143 VAL   A O   1 
ATOM   667  C  CB  . VAL   A 1 94  ? 145.121 118.949 176.426 1.00 133.30 ? 143 VAL   A CB  1 
ATOM   668  C  CG1 . VAL   A 1 94  ? 146.010 120.010 175.800 1.00 135.18 ? 143 VAL   A CG1 1 
ATOM   669  C  CG2 . VAL   A 1 94  ? 145.138 119.022 177.943 1.00 132.15 ? 143 VAL   A CG2 1 
ATOM   670  N  N   . ALA   A 1 95  ? 142.948 121.040 177.054 1.00 122.85 ? 144 ALA   A N   1 
ATOM   671  C  CA  . ALA   A 1 95  ? 142.583 122.444 177.260 1.00 125.23 ? 144 ALA   A CA  1 
ATOM   672  C  C   . ALA   A 1 95  ? 141.266 122.707 176.539 1.00 126.57 ? 144 ALA   A C   1 
ATOM   673  O  O   . ALA   A 1 95  ? 140.268 122.039 176.858 1.00 132.29 ? 144 ALA   A O   1 
ATOM   674  C  CB  . ALA   A 1 95  ? 143.758 123.332 176.845 1.00 125.77 ? 144 ALA   A CB  1 
ATOM   675  N  N   . TYR   A 1 96  ? 141.202 123.637 175.592 1.00 109.97 ? 145 TYR   A N   1 
ATOM   676  C  CA  . TYR   A 1 96  ? 139.950 123.998 174.943 1.00 114.61 ? 145 TYR   A CA  1 
ATOM   677  C  C   . TYR   A 1 96  ? 139.687 123.208 173.670 1.00 120.42 ? 145 TYR   A C   1 
ATOM   678  O  O   . TYR   A 1 96  ? 138.669 123.445 173.012 1.00 124.05 ? 145 TYR   A O   1 
ATOM   679  C  CB  . TYR   A 1 96  ? 139.938 125.496 174.627 1.00 112.68 ? 145 TYR   A CB  1 
ATOM   680  C  CG  . TYR   A 1 96  ? 139.759 126.375 175.841 1.00 113.42 ? 145 TYR   A CG  1 
ATOM   681  C  CD1 . TYR   A 1 96  ? 138.551 126.416 176.521 1.00 111.20 ? 145 TYR   A CD1 1 
ATOM   682  C  CD2 . TYR   A 1 96  ? 140.800 127.160 176.310 1.00 117.48 ? 145 TYR   A CD2 1 
ATOM   683  C  CE1 . TYR   A 1 96  ? 138.386 127.218 177.632 1.00 112.65 ? 145 TYR   A CE1 1 
ATOM   684  C  CE2 . TYR   A 1 96  ? 140.644 127.964 177.418 1.00 112.56 ? 145 TYR   A CE2 1 
ATOM   685  C  CZ  . TYR   A 1 96  ? 139.436 127.989 178.075 1.00 109.54 ? 145 TYR   A CZ  1 
ATOM   686  O  OH  . TYR   A 1 96  ? 139.281 128.790 179.181 1.00 118.12 ? 145 TYR   A OH  1 
ATOM   687  N  N   . ASP   A 1 97  ? 140.575 122.284 173.303 1.00 119.24 ? 146 ASP   A N   1 
ATOM   688  C  CA  . ASP   A 1 97  ? 140.383 121.531 172.069 1.00 116.24 ? 146 ASP   A CA  1 
ATOM   689  C  C   . ASP   A 1 97  ? 139.222 120.552 172.186 1.00 120.87 ? 146 ASP   A C   1 
ATOM   690  O  O   . ASP   A 1 97  ? 138.448 120.382 171.237 1.00 128.27 ? 146 ASP   A O   1 
ATOM   691  C  CB  . ASP   A 1 97  ? 141.669 120.794 171.702 1.00 121.00 ? 146 ASP   A CB  1 
ATOM   692  C  CG  . ASP   A 1 97  ? 142.020 120.935 170.237 1.00 124.72 ? 146 ASP   A CG  1 
ATOM   693  O  OD1 . ASP   A 1 97  ? 141.310 121.675 169.525 1.00 126.80 ? 146 ASP   A OD1 1 
ATOM   694  O  OD2 . ASP   A 1 97  ? 143.005 120.307 169.796 1.00 127.75 ? 146 ASP   A OD2 1 
ATOM   695  N  N   . VAL   A 1 98  ? 139.083 119.903 173.337 1.00 124.14 ? 147 VAL   A N   1 
ATOM   696  C  CA  . VAL   A 1 98  ? 138.078 118.863 173.540 1.00 127.38 ? 147 VAL   A CA  1 
ATOM   697  C  C   . VAL   A 1 98  ? 136.695 119.487 173.691 1.00 132.79 ? 147 VAL   A C   1 
ATOM   698  O  O   . VAL   A 1 98  ? 136.587 120.683 173.996 1.00 133.78 ? 147 VAL   A O   1 
ATOM   699  C  CB  . VAL   A 1 98  ? 138.419 118.000 174.764 1.00 128.58 ? 147 VAL   A CB  1 
ATOM   700  C  CG1 . VAL   A 1 98  ? 139.707 117.240 174.527 1.00 130.07 ? 147 VAL   A CG1 1 
ATOM   701  C  CG2 . VAL   A 1 98  ? 138.524 118.868 176.006 1.00 131.52 ? 147 VAL   A CG2 1 
ATOM   702  N  N   . PRO   A 1 99  ? 135.620 118.728 173.476 1.00 145.50 ? 148 PRO   A N   1 
ATOM   703  C  CA  . PRO   A 1 99  ? 134.277 119.235 173.788 1.00 144.63 ? 148 PRO   A CA  1 
ATOM   704  C  C   . PRO   A 1 99  ? 134.155 119.596 175.261 1.00 146.15 ? 148 PRO   A C   1 
ATOM   705  O  O   . PRO   A 1 99  ? 135.032 119.310 176.078 1.00 147.37 ? 148 PRO   A O   1 
ATOM   706  C  CB  . PRO   A 1 99  ? 133.346 118.075 173.422 1.00 144.34 ? 148 PRO   A CB  1 
ATOM   707  C  CG  . PRO   A 1 99  ? 134.140 117.163 172.564 1.00 144.78 ? 148 PRO   A CG  1 
ATOM   708  C  CD  . PRO   A 1 99  ? 135.595 117.458 172.729 1.00 142.58 ? 148 PRO   A CD  1 
ATOM   709  N  N   . ASN   A 1 100 ? 133.037 120.238 175.598 1.00 156.96 ? 149 ASN   A N   1 
ATOM   710  C  CA  . ASN   A 1 100 ? 132.835 120.765 176.944 1.00 155.54 ? 149 ASN   A CA  1 
ATOM   711  C  C   . ASN   A 1 100 ? 132.736 119.685 178.026 1.00 157.71 ? 149 ASN   A C   1 
ATOM   712  O  O   . ASN   A 1 100 ? 133.232 119.914 179.136 1.00 160.20 ? 149 ASN   A O   1 
ATOM   713  C  CB  . ASN   A 1 100 ? 131.613 121.697 176.967 1.00 156.62 ? 149 ASN   A CB  1 
ATOM   714  C  CG  . ASN   A 1 100 ? 130.284 120.961 176.966 1.00 160.00 ? 149 ASN   A CG  1 
ATOM   715  O  OD1 . ASN   A 1 100 ? 129.916 120.305 177.941 1.00 158.53 ? 149 ASN   A OD1 1 
ATOM   716  N  ND2 . ASN   A 1 100 ? 129.557 121.066 175.859 1.00 161.04 ? 149 ASN   A ND2 1 
ATOM   717  N  N   . PRO   A 1 101 ? 132.135 118.508 177.786 1.00 155.06 ? 150 PRO   A N   1 
ATOM   718  C  CA  . PRO   A 1 101 ? 132.141 117.505 178.865 1.00 156.85 ? 150 PRO   A CA  1 
ATOM   719  C  C   . PRO   A 1 101 ? 133.529 116.961 179.139 1.00 157.35 ? 150 PRO   A C   1 
ATOM   720  O  O   . PRO   A 1 101 ? 133.908 116.784 180.305 1.00 157.89 ? 150 PRO   A O   1 
ATOM   721  C  CB  . PRO   A 1 101 ? 131.189 116.415 178.345 1.00 156.55 ? 150 PRO   A CB  1 
ATOM   722  C  CG  . PRO   A 1 101 ? 130.455 117.044 177.203 1.00 155.36 ? 150 PRO   A CG  1 
ATOM   723  C  CD  . PRO   A 1 101 ? 131.448 117.970 176.598 1.00 154.43 ? 150 PRO   A CD  1 
ATOM   724  N  N   . VAL   A 1 102 ? 134.307 116.702 178.087 1.00 152.23 ? 151 VAL   A N   1 
ATOM   725  C  CA  . VAL   A 1 102 ? 135.690 116.275 178.270 1.00 151.25 ? 151 VAL   A CA  1 
ATOM   726  C  C   . VAL   A 1 102 ? 136.493 117.372 178.955 1.00 154.41 ? 151 VAL   A C   1 
ATOM   727  O  O   . VAL   A 1 102 ? 137.367 117.095 179.784 1.00 156.59 ? 151 VAL   A O   1 
ATOM   728  C  CB  . VAL   A 1 102 ? 136.309 115.876 176.919 1.00 152.98 ? 151 VAL   A CB  1 
ATOM   729  C  CG1 . VAL   A 1 102 ? 137.668 115.235 177.128 1.00 151.76 ? 151 VAL   A CG1 1 
ATOM   730  C  CG2 . VAL   A 1 102 ? 135.380 114.935 176.170 1.00 155.55 ? 151 VAL   A CG2 1 
ATOM   731  N  N   . PHE   A 1 103 ? 136.212 118.633 178.620 1.00 150.33 ? 152 PHE   A N   1 
ATOM   732  C  CA  . PHE   A 1 103 ? 136.894 119.745 179.274 1.00 147.10 ? 152 PHE   A CA  1 
ATOM   733  C  C   . PHE   A 1 103 ? 136.579 119.783 180.763 1.00 145.59 ? 152 PHE   A C   1 
ATOM   734  O  O   . PHE   A 1 103 ? 137.471 120.011 181.587 1.00 150.60 ? 152 PHE   A O   1 
ATOM   735  C  CB  . PHE   A 1 103 ? 136.502 121.062 178.605 1.00 144.63 ? 152 PHE   A CB  1 
ATOM   736  C  CG  . PHE   A 1 103 ? 137.097 122.275 179.257 1.00 144.79 ? 152 PHE   A CG  1 
ATOM   737  C  CD1 . PHE   A 1 103 ? 138.414 122.278 179.681 1.00 144.19 ? 152 PHE   A CD1 1 
ATOM   738  C  CD2 . PHE   A 1 103 ? 136.335 123.414 179.450 1.00 148.80 ? 152 PHE   A CD2 1 
ATOM   739  C  CE1 . PHE   A 1 103 ? 138.958 123.393 180.283 1.00 147.07 ? 152 PHE   A CE1 1 
ATOM   740  C  CE2 . PHE   A 1 103 ? 136.876 124.533 180.052 1.00 146.80 ? 152 PHE   A CE2 1 
ATOM   741  C  CZ  . PHE   A 1 103 ? 138.189 124.521 180.469 1.00 145.73 ? 152 PHE   A CZ  1 
ATOM   742  N  N   . LEU   A 1 104 ? 135.314 119.567 181.127 1.00 137.30 ? 153 LEU   A N   1 
ATOM   743  C  CA  . LEU   A 1 104 ? 134.952 119.519 182.540 1.00 138.59 ? 153 LEU   A CA  1 
ATOM   744  C  C   . LEU   A 1 104 ? 135.635 118.354 183.246 1.00 144.95 ? 153 LEU   A C   1 
ATOM   745  O  O   . LEU   A 1 104 ? 136.086 118.488 184.391 1.00 147.17 ? 153 LEU   A O   1 
ATOM   746  C  CB  . LEU   A 1 104 ? 133.435 119.426 182.692 1.00 142.57 ? 153 LEU   A CB  1 
ATOM   747  C  CG  . LEU   A 1 104 ? 132.644 120.657 182.251 1.00 145.52 ? 153 LEU   A CG  1 
ATOM   748  C  CD1 . LEU   A 1 104 ? 131.156 120.450 182.481 1.00 145.90 ? 153 LEU   A CD1 1 
ATOM   749  C  CD2 . LEU   A 1 104 ? 133.138 121.893 182.983 1.00 143.85 ? 153 LEU   A CD2 1 
ATOM   750  N  N   . GLU   A 1 105 ? 135.707 117.196 182.583 1.00 153.43 ? 154 GLU   A N   1 
ATOM   751  C  CA  . GLU   A 1 105 ? 136.400 116.054 183.173 1.00 152.32 ? 154 GLU   A CA  1 
ATOM   752  C  C   . GLU   A 1 105 ? 137.875 116.363 183.402 1.00 154.49 ? 154 GLU   A C   1 
ATOM   753  O  O   . GLU   A 1 105 ? 138.431 116.038 184.458 1.00 154.09 ? 154 GLU   A O   1 
ATOM   754  C  CB  . GLU   A 1 105 ? 136.240 114.822 182.283 1.00 152.20 ? 154 GLU   A CB  1 
ATOM   755  C  CG  . GLU   A 1 105 ? 134.804 114.352 182.129 1.00 155.97 ? 154 GLU   A CG  1 
ATOM   756  C  CD  . GLU   A 1 105 ? 134.639 113.325 181.027 1.00 158.52 ? 154 GLU   A CD  1 
ATOM   757  O  OE1 . GLU   A 1 105 ? 135.231 112.231 181.138 1.00 159.52 ? 154 GLU   A OE1 1 
ATOM   758  O  OE2 . GLU   A 1 105 ? 133.916 113.611 180.050 1.00 157.33 ? 154 GLU   A OE2 1 
ATOM   759  N  N   . GLN   A 1 106 ? 138.522 116.998 182.425 1.00 144.60 ? 155 GLN   A N   1 
ATOM   760  C  CA  . GLN   A 1 106 ? 139.919 117.385 182.590 1.00 140.49 ? 155 GLN   A CA  1 
ATOM   761  C  C   . GLN   A 1 106 ? 140.079 118.387 183.725 1.00 142.49 ? 155 GLN   A C   1 
ATOM   762  O  O   . GLN   A 1 106 ? 141.029 118.301 184.512 1.00 144.93 ? 155 GLN   A O   1 
ATOM   763  C  CB  . GLN   A 1 106 ? 140.458 117.965 181.283 1.00 136.08 ? 155 GLN   A CB  1 
ATOM   764  C  CG  . GLN   A 1 106 ? 140.436 116.996 180.114 1.00 138.70 ? 155 GLN   A CG  1 
ATOM   765  C  CD  . GLN   A 1 106 ? 141.485 117.321 179.074 1.00 140.79 ? 155 GLN   A CD  1 
ATOM   766  O  OE1 . GLN   A 1 106 ? 142.460 118.013 179.359 1.00 138.12 ? 155 GLN   A OE1 1 
ATOM   767  N  NE2 . GLN   A 1 106 ? 141.292 116.820 177.861 1.00 143.07 ? 155 GLN   A NE2 1 
ATOM   768  N  N   . LYS   A 1 107 ? 139.157 119.346 183.823 1.00 144.15 ? 156 LYS   A N   1 
ATOM   769  C  CA  . LYS   A 1 107 ? 139.239 120.353 184.874 1.00 143.39 ? 156 LYS   A CA  1 
ATOM   770  C  C   . LYS   A 1 107 ? 139.113 119.724 186.255 1.00 146.66 ? 156 LYS   A C   1 
ATOM   771  O  O   . LYS   A 1 107 ? 139.871 120.066 187.170 1.00 150.98 ? 156 LYS   A O   1 
ATOM   772  C  CB  . LYS   A 1 107 ? 138.161 121.417 184.661 1.00 140.59 ? 156 LYS   A CB  1 
ATOM   773  C  CG  . LYS   A 1 107 ? 137.589 121.998 185.941 1.00 143.98 ? 156 LYS   A CG  1 
ATOM   774  C  CD  . LYS   A 1 107 ? 136.828 123.286 185.671 1.00 147.37 ? 156 LYS   A CD  1 
ATOM   775  C  CE  . LYS   A 1 107 ? 136.142 123.793 186.929 1.00 149.69 ? 156 LYS   A CE  1 
ATOM   776  N  NZ  . LYS   A 1 107 ? 135.780 125.233 186.826 1.00 145.10 ? 156 LYS   A NZ  1 
ATOM   777  N  N   . LYS   A 1 108 ? 138.171 118.793 186.428 1.00 147.79 ? 157 LYS   A N   1 
ATOM   778  C  CA  . LYS   A 1 108 ? 138.033 118.160 187.737 1.00 149.01 ? 157 LYS   A CA  1 
ATOM   779  C  C   . LYS   A 1 108 ? 139.207 117.235 188.036 1.00 150.74 ? 157 LYS   A C   1 
ATOM   780  O  O   . LYS   A 1 108 ? 139.644 117.147 189.190 1.00 153.87 ? 157 LYS   A O   1 
ATOM   781  C  CB  . LYS   A 1 108 ? 136.706 117.405 187.847 1.00 149.35 ? 157 LYS   A CB  1 
ATOM   782  C  CG  . LYS   A 1 108 ? 136.445 116.384 186.762 1.00 153.84 ? 157 LYS   A CG  1 
ATOM   783  C  CD  . LYS   A 1 108 ? 135.605 115.228 187.281 1.00 153.36 ? 157 LYS   A CD  1 
ATOM   784  C  CE  . LYS   A 1 108 ? 135.349 114.197 186.194 1.00 152.43 ? 157 LYS   A CE  1 
ATOM   785  N  NZ  . LYS   A 1 108 ? 136.611 113.597 185.682 1.00 149.21 ? 157 LYS   A NZ  1 
ATOM   786  N  N   . MET   A 1 109 ? 139.750 116.563 187.015 1.00 145.01 ? 158 MET   A N   1 
ATOM   787  C  CA  . MET   A 1 109 ? 140.941 115.747 187.227 1.00 143.07 ? 158 MET   A CA  1 
ATOM   788  C  C   . MET   A 1 109 ? 142.115 116.603 187.683 1.00 145.39 ? 158 MET   A C   1 
ATOM   789  O  O   . MET   A 1 109 ? 142.882 116.200 188.566 1.00 147.20 ? 158 MET   A O   1 
ATOM   790  C  CB  . MET   A 1 109 ? 141.299 114.993 185.948 1.00 139.81 ? 158 MET   A CB  1 
ATOM   791  C  CG  . MET   A 1 109 ? 141.428 113.493 186.129 1.00 144.54 ? 158 MET   A CG  1 
ATOM   792  S  SD  . MET   A 1 109 ? 141.572 112.621 184.559 1.00 156.78 ? 158 MET   A SD  1 
ATOM   793  C  CE  . MET   A 1 109 ? 140.236 113.369 183.634 1.00 148.31 ? 158 MET   A CE  1 
ATOM   794  N  N   . LEU   A 1 110 ? 142.276 117.784 187.085 1.00 131.23 ? 159 LEU   A N   1 
ATOM   795  C  CA  . LEU   A 1 110 ? 143.340 118.690 187.506 1.00 132.40 ? 159 LEU   A CA  1 
ATOM   796  C  C   . LEU   A 1 110 ? 143.098 119.214 188.915 1.00 132.68 ? 159 LEU   A C   1 
ATOM   797  O  O   . LEU   A 1 110 ? 144.031 119.290 189.724 1.00 130.10 ? 159 LEU   A O   1 
ATOM   798  C  CB  . LEU   A 1 110 ? 143.459 119.848 186.518 1.00 127.86 ? 159 LEU   A CB  1 
ATOM   799  C  CG  . LEU   A 1 110 ? 144.366 119.592 185.318 1.00 128.10 ? 159 LEU   A CG  1 
ATOM   800  C  CD1 . LEU   A 1 110 ? 144.321 120.768 184.370 1.00 131.78 ? 159 LEU   A CD1 1 
ATOM   801  C  CD2 . LEU   A 1 110 ? 145.785 119.327 185.778 1.00 131.75 ? 159 LEU   A CD2 1 
ATOM   802  N  N   . LYS   A 1 111 ? 141.854 119.584 189.228 1.00 132.33 ? 160 LYS   A N   1 
ATOM   803  C  CA  . LYS   A 1 111 ? 141.545 120.100 190.556 1.00 129.87 ? 160 LYS   A CA  1 
ATOM   804  C  C   . LYS   A 1 111 ? 141.729 119.038 191.631 1.00 132.30 ? 160 LYS   A C   1 
ATOM   805  O  O   . LYS   A 1 111 ? 141.972 119.374 192.795 1.00 135.27 ? 160 LYS   A O   1 
ATOM   806  C  CB  . LYS   A 1 111 ? 140.118 120.646 190.590 1.00 129.08 ? 160 LYS   A CB  1 
ATOM   807  C  CG  . LYS   A 1 111 ? 139.828 121.547 191.778 1.00 131.61 ? 160 LYS   A CG  1 
ATOM   808  C  CD  . LYS   A 1 111 ? 139.084 122.800 191.353 1.00 132.90 ? 160 LYS   A CD  1 
ATOM   809  C  CE  . LYS   A 1 111 ? 137.718 122.462 190.782 1.00 135.19 ? 160 LYS   A CE  1 
ATOM   810  N  NZ  . LYS   A 1 111 ? 137.083 123.641 190.134 1.00 132.79 ? 160 LYS   A NZ  1 
ATOM   811  N  N   . SER   A 1 112 ? 141.611 117.760 191.266 1.00 133.23 ? 161 SER   A N   1 
ATOM   812  C  CA  . SER   A 1 112 ? 141.827 116.696 192.241 1.00 131.41 ? 161 SER   A CA  1 
ATOM   813  C  C   . SER   A 1 112 ? 143.256 116.710 192.770 1.00 133.08 ? 161 SER   A C   1 
ATOM   814  O  O   . SER   A 1 112 ? 143.487 116.474 193.961 1.00 136.73 ? 161 SER   A O   1 
ATOM   815  C  CB  . SER   A 1 112 ? 141.501 115.339 191.619 1.00 133.64 ? 161 SER   A CB  1 
ATOM   816  O  OG  . SER   A 1 112 ? 142.038 114.282 192.394 1.00 133.80 ? 161 SER   A OG  1 
ATOM   817  N  N   . GLY   A 1 113 ? 144.229 116.978 191.898 1.00 125.94 ? 162 GLY   A N   1 
ATOM   818  C  CA  . GLY   A 1 113 ? 145.618 116.974 192.331 1.00 128.12 ? 162 GLY   A CA  1 
ATOM   819  C  C   . GLY   A 1 113 ? 145.944 118.086 193.311 1.00 129.62 ? 162 GLY   A C   1 
ATOM   820  O  O   . GLY   A 1 113 ? 146.637 117.862 194.307 1.00 129.50 ? 162 GLY   A O   1 
ATOM   821  N  N   . LEU   A 1 114 ? 145.457 119.295 193.045 1.00 125.82 ? 163 LEU   A N   1 
ATOM   822  C  CA  . LEU   A 1 114 ? 145.746 120.456 193.886 1.00 122.30 ? 163 LEU   A CA  1 
ATOM   823  C  C   . LEU   A 1 114 ? 144.897 120.361 195.147 1.00 119.14 ? 163 LEU   A C   1 
ATOM   824  O  O   . LEU   A 1 114 ? 143.775 120.863 195.209 1.00 121.55 ? 163 LEU   A O   1 
ATOM   825  C  CB  . LEU   A 1 114 ? 145.477 121.751 193.130 1.00 121.30 ? 163 LEU   A CB  1 
ATOM   826  C  CG  . LEU   A 1 114 ? 146.428 122.080 191.979 1.00 115.39 ? 163 LEU   A CG  1 
ATOM   827  C  CD1 . LEU   A 1 114 ? 145.789 123.074 191.025 1.00 110.00 ? 163 LEU   A CD1 1 
ATOM   828  C  CD2 . LEU   A 1 114 ? 147.744 122.616 192.510 1.00 113.90 ? 163 LEU   A CD2 1 
ATOM   829  N  N   . ASN   A 1 115 ? 145.443 119.707 196.169 1.00 128.13 ? 164 ASN   A N   1 
ATOM   830  C  CA  . ASN   A 1 115 ? 144.740 119.497 197.425 1.00 133.48 ? 164 ASN   A CA  1 
ATOM   831  C  C   . ASN   A 1 115 ? 145.616 119.955 198.586 1.00 138.90 ? 164 ASN   A C   1 
ATOM   832  O  O   . ASN   A 1 115 ? 146.751 120.409 198.403 1.00 139.08 ? 164 ASN   A O   1 
ATOM   833  C  CB  . ASN   A 1 115 ? 144.332 118.027 197.590 1.00 132.32 ? 164 ASN   A CB  1 
ATOM   834  C  CG  . ASN   A 1 115 ? 145.523 117.096 197.680 1.00 136.06 ? 164 ASN   A CG  1 
ATOM   835  O  OD1 . ASN   A 1 115 ? 146.635 117.451 197.292 1.00 132.27 ? 164 ASN   A OD1 1 
ATOM   836  N  ND2 . ASN   A 1 115 ? 145.295 115.894 198.194 1.00 138.98 ? 164 ASN   A ND2 1 
ATOM   837  N  N   . ILE   A 1 116 ? 145.067 119.828 199.796 1.00 135.63 ? 165 ILE   A N   1 
ATOM   838  C  CA  . ILE   A 1 116 ? 145.764 120.282 200.995 1.00 133.28 ? 165 ILE   A CA  1 
ATOM   839  C  C   . ILE   A 1 116 ? 147.029 119.463 201.224 1.00 133.16 ? 165 ILE   A C   1 
ATOM   840  O  O   . ILE   A 1 116 ? 148.060 119.994 201.657 1.00 134.61 ? 165 ILE   A O   1 
ATOM   841  C  CB  . ILE   A 1 116 ? 144.812 120.223 202.206 1.00 132.71 ? 165 ILE   A CB  1 
ATOM   842  C  CG1 . ILE   A 1 116 ? 144.093 121.561 202.393 1.00 131.85 ? 165 ILE   A CG1 1 
ATOM   843  C  CG2 . ILE   A 1 116 ? 145.555 119.839 203.478 1.00 133.08 ? 165 ILE   A CG2 1 
ATOM   844  C  CD1 . ILE   A 1 116 ? 143.070 121.872 201.323 1.00 131.22 ? 165 ILE   A CD1 1 
ATOM   845  N  N   . ALA   A 1 117 ? 146.973 118.161 200.936 1.00 134.60 ? 166 ALA   A N   1 
ATOM   846  C  CA  . ALA   A 1 117 ? 148.143 117.311 201.127 1.00 139.54 ? 166 ALA   A CA  1 
ATOM   847  C  C   . ALA   A 1 117 ? 149.303 117.764 200.251 1.00 139.92 ? 166 ALA   A C   1 
ATOM   848  O  O   . ALA   A 1 117 ? 150.452 117.814 200.705 1.00 140.28 ? 166 ALA   A O   1 
ATOM   849  C  CB  . ALA   A 1 117 ? 147.786 115.854 200.838 1.00 138.27 ? 166 ALA   A CB  1 
ATOM   850  N  N   . HIS   A 1 118 ? 149.023 118.099 198.990 1.00 134.53 ? 167 HIS   A N   1 
ATOM   851  C  CA  . HIS   A 1 118 ? 150.078 118.595 198.113 1.00 134.20 ? 167 HIS   A CA  1 
ATOM   852  C  C   . HIS   A 1 118 ? 150.519 119.996 198.516 1.00 136.76 ? 167 HIS   A C   1 
ATOM   853  O  O   . HIS   A 1 118 ? 151.704 120.331 198.413 1.00 135.56 ? 167 HIS   A O   1 
ATOM   854  C  CB  . HIS   A 1 118 ? 149.607 118.576 196.660 1.00 130.89 ? 167 HIS   A CB  1 
ATOM   855  C  CG  . HIS   A 1 118 ? 149.527 117.203 196.071 1.00 136.80 ? 167 HIS   A CG  1 
ATOM   856  N  ND1 . HIS   A 1 118 ? 148.897 116.942 194.874 1.00 140.83 ? 167 HIS   A ND1 1 
ATOM   857  C  CD2 . HIS   A 1 118 ? 149.999 116.015 196.514 1.00 138.87 ? 167 HIS   A CD2 1 
ATOM   858  C  CE1 . HIS   A 1 118 ? 148.984 115.652 194.605 1.00 136.22 ? 167 HIS   A CE1 1 
ATOM   859  N  NE2 . HIS   A 1 118 ? 149.649 115.066 195.584 1.00 136.61 ? 167 HIS   A NE2 1 
ATOM   860  N  N   . PHE   A 1 119 ? 149.583 120.827 198.981 1.00 126.54 ? 168 PHE   A N   1 
ATOM   861  C  CA  . PHE   A 1 119 ? 149.940 122.184 199.385 1.00 122.86 ? 168 PHE   A CA  1 
ATOM   862  C  C   . PHE   A 1 119 ? 150.862 122.188 200.597 1.00 126.38 ? 168 PHE   A C   1 
ATOM   863  O  O   . PHE   A 1 119 ? 151.711 123.080 200.727 1.00 126.13 ? 168 PHE   A O   1 
ATOM   864  C  CB  . PHE   A 1 119 ? 148.678 122.993 199.680 1.00 116.81 ? 168 PHE   A CB  1 
ATOM   865  C  CG  . PHE   A 1 119 ? 147.872 123.327 198.459 1.00 111.51 ? 168 PHE   A CG  1 
ATOM   866  C  CD1 . PHE   A 1 119 ? 148.385 123.122 197.193 1.00 116.74 ? 168 PHE   A CD1 1 
ATOM   867  C  CD2 . PHE   A 1 119 ? 146.598 123.848 198.581 1.00 116.87 ? 168 PHE   A CD2 1 
ATOM   868  C  CE1 . PHE   A 1 119 ? 147.644 123.430 196.073 1.00 116.29 ? 168 PHE   A CE1 1 
ATOM   869  C  CE2 . PHE   A 1 119 ? 145.854 124.158 197.464 1.00 118.83 ? 168 PHE   A CE2 1 
ATOM   870  C  CZ  . PHE   A 1 119 ? 146.378 123.948 196.209 1.00 115.38 ? 168 PHE   A CZ  1 
ATOM   871  N  N   . LYS   A 1 120 ? 150.705 121.211 201.493 1.00 136.67 ? 169 LYS   A N   1 
ATOM   872  C  CA  . LYS   A 1 120 ? 151.548 121.155 202.684 1.00 134.25 ? 169 LYS   A CA  1 
ATOM   873  C  C   . LYS   A 1 120 ? 153.020 121.013 202.323 1.00 134.63 ? 169 LYS   A C   1 
ATOM   874  O  O   . LYS   A 1 120 ? 153.888 121.488 203.064 1.00 135.27 ? 169 LYS   A O   1 
ATOM   875  C  CB  . LYS   A 1 120 ? 151.108 120.002 203.586 1.00 131.14 ? 169 LYS   A CB  1 
ATOM   876  C  CG  . LYS   A 1 120 ? 150.059 120.388 204.613 1.00 134.65 ? 169 LYS   A CG  1 
ATOM   877  C  CD  . LYS   A 1 120 ? 149.003 119.306 204.757 1.00 137.71 ? 169 LYS   A CD  1 
ATOM   878  C  CE  . LYS   A 1 120 ? 148.322 119.373 206.115 1.00 136.08 ? 169 LYS   A CE  1 
ATOM   879  N  NZ  . LYS   A 1 120 ? 148.372 120.743 206.698 1.00 135.30 ? 169 LYS   A NZ  1 
ATOM   880  N  N   . GLN   A 1 121 ? 153.321 120.367 201.198 1.00 125.00 ? 170 GLN   A N   1 
ATOM   881  C  CA  . GLN   A 1 121 ? 154.690 120.294 200.705 1.00 125.25 ? 170 GLN   A CA  1 
ATOM   882  C  C   . GLN   A 1 121 ? 155.025 121.437 199.761 1.00 125.79 ? 170 GLN   A C   1 
ATOM   883  O  O   . GLN   A 1 121 ? 156.189 121.855 199.692 1.00 126.94 ? 170 GLN   A O   1 
ATOM   884  C  CB  . GLN   A 1 121 ? 154.926 118.960 199.993 1.00 128.01 ? 170 GLN   A CB  1 
ATOM   885  C  CG  . GLN   A 1 121 ? 154.414 117.750 200.755 1.00 130.51 ? 170 GLN   A CG  1 
ATOM   886  C  CD  . GLN   A 1 121 ? 153.752 116.731 199.850 1.00 131.43 ? 170 GLN   A CD  1 
ATOM   887  O  OE1 . GLN   A 1 121 ? 153.788 116.854 198.626 1.00 131.99 ? 170 GLN   A OE1 1 
ATOM   888  N  NE2 . GLN   A 1 121 ? 153.142 115.716 200.449 1.00 126.14 ? 170 GLN   A NE2 1 
ATOM   889  N  N   . HIS   A 1 122 ? 154.028 121.945 199.031 1.00 119.90 ? 171 HIS   A N   1 
ATOM   890  C  CA  . HIS   A 1 122 ? 154.263 123.071 198.135 1.00 125.63 ? 171 HIS   A CA  1 
ATOM   891  C  C   . HIS   A 1 122 ? 154.735 124.294 198.905 1.00 127.02 ? 171 HIS   A C   1 
ATOM   892  O  O   . HIS   A 1 122 ? 155.573 125.057 198.415 1.00 127.84 ? 171 HIS   A O   1 
ATOM   893  C  CB  . HIS   A 1 122 ? 152.995 123.397 197.346 1.00 123.19 ? 171 HIS   A CB  1 
ATOM   894  C  CG  . HIS   A 1 122 ? 152.600 122.339 196.364 1.00 126.03 ? 171 HIS   A CG  1 
ATOM   895  N  ND1 . HIS   A 1 122 ? 153.417 121.276 196.046 1.00 132.88 ? 171 HIS   A ND1 1 
ATOM   896  C  CD2 . HIS   A 1 122 ? 151.475 122.182 195.628 1.00 122.98 ? 171 HIS   A CD2 1 
ATOM   897  C  CE1 . HIS   A 1 122 ? 152.811 120.508 195.158 1.00 127.25 ? 171 HIS   A CE1 1 
ATOM   898  N  NE2 . HIS   A 1 122 ? 151.631 121.035 194.887 1.00 121.07 ? 171 HIS   A NE2 1 
ATOM   899  N  N   . VAL   A 1 123 ? 154.203 124.502 200.111 1.00 122.23 ? 172 VAL   A N   1 
ATOM   900  C  CA  . VAL   A 1 123 ? 154.623 125.647 200.917 1.00 118.21 ? 172 VAL   A CA  1 
ATOM   901  C  C   . VAL   A 1 123 ? 156.121 125.583 201.186 1.00 113.40 ? 172 VAL   A C   1 
ATOM   902  O  O   . VAL   A 1 123 ? 156.854 126.554 200.960 1.00 120.08 ? 172 VAL   A O   1 
ATOM   903  C  CB  . VAL   A 1 123 ? 153.823 125.709 202.230 1.00 119.84 ? 172 VAL   A CB  1 
ATOM   904  C  CG1 . VAL   A 1 123 ? 154.598 126.483 203.281 1.00 113.10 ? 172 VAL   A CG1 1 
ATOM   905  C  CG2 . VAL   A 1 123 ? 152.477 126.350 201.998 1.00 119.97 ? 172 VAL   A CG2 1 
ATOM   906  N  N   . SER   A 1 124 ? 156.599 124.431 201.661 1.00 108.83 ? 173 SER   A N   1 
ATOM   907  C  CA  . SER   A 1 124 ? 158.018 124.289 201.967 1.00 110.67 ? 173 SER   A CA  1 
ATOM   908  C  C   . SER   A 1 124 ? 158.868 124.384 200.707 1.00 120.62 ? 173 SER   A C   1 
ATOM   909  O  O   . SER   A 1 124 ? 159.945 124.992 200.725 1.00 121.16 ? 173 SER   A O   1 
ATOM   910  C  CB  . SER   A 1 124 ? 158.269 122.966 202.687 1.00 114.62 ? 173 SER   A CB  1 
ATOM   911  O  OG  . SER   A 1 124 ? 159.656 122.704 202.798 1.00 117.71 ? 173 SER   A OG  1 
ATOM   912  N  N   . ILE   A 1 125 ? 158.401 123.795 199.603 1.00 123.97 ? 174 ILE   A N   1 
ATOM   913  C  CA  . ILE   A 1 125 ? 159.164 123.844 198.358 1.00 120.01 ? 174 ILE   A CA  1 
ATOM   914  C  C   . ILE   A 1 125 ? 159.325 125.285 197.890 1.00 119.60 ? 174 ILE   A C   1 
ATOM   915  O  O   . ILE   A 1 125 ? 160.426 125.724 197.534 1.00 119.35 ? 174 ILE   A O   1 
ATOM   916  C  CB  . ILE   A 1 125 ? 158.493 122.973 197.281 1.00 118.33 ? 174 ILE   A CB  1 
ATOM   917  C  CG1 . ILE   A 1 125 ? 158.552 121.495 197.671 1.00 123.19 ? 174 ILE   A CG1 1 
ATOM   918  C  CG2 . ILE   A 1 125 ? 159.147 123.199 195.934 1.00 120.01 ? 174 ILE   A CG2 1 
ATOM   919  C  CD1 . ILE   A 1 125 ? 159.948 120.991 197.951 1.00 125.12 ? 174 ILE   A CD1 1 
ATOM   920  N  N   . ILE   A 1 126 ? 158.229 126.047 197.898 1.00 111.51 ? 175 ILE   A N   1 
ATOM   921  C  CA  . ILE   A 1 126 ? 158.277 127.432 197.447 1.00 106.38 ? 175 ILE   A CA  1 
ATOM   922  C  C   . ILE   A 1 126 ? 159.132 128.274 198.383 1.00 107.20 ? 175 ILE   A C   1 
ATOM   923  O  O   . ILE   A 1 126 ? 159.890 129.141 197.935 1.00 114.19 ? 175 ILE   A O   1 
ATOM   924  C  CB  . ILE   A 1 126 ? 156.853 128.001 197.317 1.00 107.05 ? 175 ILE   A CB  1 
ATOM   925  C  CG1 . ILE   A 1 126 ? 156.074 127.250 196.240 1.00 110.93 ? 175 ILE   A CG1 1 
ATOM   926  C  CG2 . ILE   A 1 126 ? 156.902 129.469 196.986 1.00 110.06 ? 175 ILE   A CG2 1 
ATOM   927  C  CD1 . ILE   A 1 126 ? 154.577 127.365 196.386 1.00 110.73 ? 175 ILE   A CD1 1 
ATOM   928  N  N   . GLU   A 1 127 ? 159.025 128.042 199.693 1.00 117.66 ? 176 GLU   A N   1 
ATOM   929  C  CA  . GLU   A 1 127 ? 159.847 128.789 200.639 1.00 116.03 ? 176 GLU   A CA  1 
ATOM   930  C  C   . GLU   A 1 127 ? 161.329 128.533 200.398 1.00 121.17 ? 176 GLU   A C   1 
ATOM   931  O  O   . GLU   A 1 127 ? 162.136 129.470 200.359 1.00 126.45 ? 176 GLU   A O   1 
ATOM   932  C  CB  . GLU   A 1 127 ? 159.464 128.419 202.070 1.00 121.34 ? 176 GLU   A CB  1 
ATOM   933  C  CG  . GLU   A 1 127 ? 159.768 129.498 203.087 1.00 117.65 ? 176 GLU   A CG  1 
ATOM   934  C  CD  . GLU   A 1 127 ? 159.792 128.964 204.501 1.00 125.44 ? 176 GLU   A CD  1 
ATOM   935  O  OE1 . GLU   A 1 127 ? 160.750 128.244 204.848 1.00 124.54 ? 176 GLU   A OE1 1 
ATOM   936  O  OE2 . GLU   A 1 127 ? 158.851 129.261 205.263 1.00 126.56 ? 176 GLU   A OE2 1 
ATOM   937  N  N   . LYS   A 1 128 ? 161.704 127.265 200.218 1.00 133.60 ? 177 LYS   A N   1 
ATOM   938  C  CA  . LYS   A 1 128 ? 163.103 126.942 199.960 1.00 137.41 ? 177 LYS   A CA  1 
ATOM   939  C  C   . LYS   A 1 128 ? 163.578 127.577 198.660 1.00 133.20 ? 177 LYS   A C   1 
ATOM   940  O  O   . LYS   A 1 128 ? 164.670 128.156 198.599 1.00 133.19 ? 177 LYS   A O   1 
ATOM   941  C  CB  . LYS   A 1 128 ? 163.290 125.426 199.917 1.00 134.40 ? 177 LYS   A CB  1 
ATOM   942  C  CG  . LYS   A 1 128 ? 164.741 124.983 199.976 1.00 134.65 ? 177 LYS   A CG  1 
ATOM   943  C  CD  . LYS   A 1 128 ? 164.896 123.551 199.499 1.00 136.37 ? 177 LYS   A CD  1 
ATOM   944  C  CE  . LYS   A 1 128 ? 164.471 123.408 198.048 1.00 137.56 ? 177 LYS   A CE  1 
ATOM   945  N  NZ  . LYS   A 1 128 ? 165.553 123.814 197.111 1.00 134.48 ? 177 LYS   A NZ  1 
ATOM   946  N  N   . GLU   A 1 129 ? 162.759 127.490 197.609 1.00 123.16 ? 178 GLU   A N   1 
ATOM   947  C  CA  . GLU   A 1 129 ? 163.172 128.024 196.317 1.00 120.45 ? 178 GLU   A CA  1 
ATOM   948  C  C   . GLU   A 1 129 ? 163.327 129.539 196.357 1.00 122.62 ? 178 GLU   A C   1 
ATOM   949  O  O   . GLU   A 1 129 ? 164.287 130.076 195.798 1.00 129.71 ? 178 GLU   A O   1 
ATOM   950  C  CB  . GLU   A 1 129 ? 162.184 127.606 195.231 1.00 125.38 ? 178 GLU   A CB  1 
ATOM   951  C  CG  . GLU   A 1 129 ? 162.245 126.125 194.914 1.00 130.52 ? 178 GLU   A CG  1 
ATOM   952  C  CD  . GLU   A 1 129 ? 162.030 125.834 193.447 1.00 129.18 ? 178 GLU   A CD  1 
ATOM   953  O  OE1 . GLU   A 1 129 ? 161.488 126.709 192.741 1.00 127.58 ? 178 GLU   A OE1 1 
ATOM   954  O  OE2 . GLU   A 1 129 ? 162.417 124.737 192.996 1.00 128.03 ? 178 GLU   A OE2 1 
ATOM   955  N  N   . THR   A 1 130 ? 162.408 130.249 197.016 1.00 112.45 ? 179 THR   A N   1 
ATOM   956  C  CA  . THR   A 1 130 ? 162.536 131.703 197.080 1.00 108.71 ? 179 THR   A CA  1 
ATOM   957  C  C   . THR   A 1 130 ? 163.703 132.119 197.969 1.00 113.24 ? 179 THR   A C   1 
ATOM   958  O  O   . THR   A 1 130 ? 164.413 133.083 197.653 1.00 118.90 ? 179 THR   A O   1 
ATOM   959  C  CB  . THR   A 1 130 ? 161.229 132.346 197.549 1.00 112.56 ? 179 THR   A CB  1 
ATOM   960  O  OG1 . THR   A 1 130 ? 161.350 133.771 197.486 1.00 118.57 ? 179 THR   A OG1 1 
ATOM   961  C  CG2 . THR   A 1 130 ? 160.885 131.944 198.963 1.00 121.43 ? 179 THR   A CG2 1 
ATOM   962  N  N   . LYS   A 1 131 ? 163.938 131.395 199.069 1.00 123.69 ? 180 LYS   A N   1 
ATOM   963  C  CA  . LYS   A 1 131 ? 165.073 131.718 199.924 1.00 127.39 ? 180 LYS   A CA  1 
ATOM   964  C  C   . LYS   A 1 131 ? 166.389 131.505 199.190 1.00 131.40 ? 180 LYS   A C   1 
ATOM   965  O  O   . LYS   A 1 131 ? 167.341 132.272 199.373 1.00 128.20 ? 180 LYS   A O   1 
ATOM   966  C  CB  . LYS   A 1 131 ? 165.023 130.879 201.200 1.00 121.62 ? 180 LYS   A CB  1 
ATOM   967  C  CG  . LYS   A 1 131 ? 164.694 131.677 202.449 1.00 128.73 ? 180 LYS   A CG  1 
ATOM   968  C  CD  . LYS   A 1 131 ? 164.387 130.765 203.624 1.00 130.10 ? 180 LYS   A CD  1 
ATOM   969  C  CE  . LYS   A 1 131 ? 164.400 131.533 204.935 1.00 131.12 ? 180 LYS   A CE  1 
ATOM   970  N  NZ  . LYS   A 1 131 ? 164.120 130.650 206.100 1.00 128.10 ? 180 LYS   A NZ  1 
ATOM   971  N  N   . GLU   A 1 132 ? 166.463 130.468 198.353 1.00 136.61 ? 181 GLU   A N   1 
ATOM   972  C  CA  . GLU   A 1 132 ? 167.680 130.236 197.584 1.00 130.79 ? 181 GLU   A CA  1 
ATOM   973  C  C   . GLU   A 1 132 ? 167.823 131.229 196.436 1.00 129.93 ? 181 GLU   A C   1 
ATOM   974  O  O   . GLU   A 1 132 ? 168.937 131.669 196.131 1.00 133.89 ? 181 GLU   A O   1 
ATOM   975  C  CB  . GLU   A 1 132 ? 167.698 128.803 197.053 1.00 130.92 ? 181 GLU   A CB  1 
ATOM   976  C  CG  . GLU   A 1 132 ? 168.283 127.794 198.027 1.00 134.86 ? 181 GLU   A CG  1 
ATOM   977  C  CD  . GLU   A 1 132 ? 168.212 126.373 197.506 1.00 138.67 ? 181 GLU   A CD  1 
ATOM   978  O  OE1 . GLU   A 1 132 ? 167.877 126.191 196.316 1.00 139.71 ? 181 GLU   A OE1 1 
ATOM   979  O  OE2 . GLU   A 1 132 ? 168.490 125.439 198.286 1.00 138.80 ? 181 GLU   A OE2 1 
ATOM   980  N  N   . TYR   A 1 133 ? 166.715 131.596 195.790 1.00 109.51 ? 182 TYR   A N   1 
ATOM   981  C  CA  . TYR   A 1 133 ? 166.789 132.445 194.608 1.00 110.37 ? 182 TYR   A CA  1 
ATOM   982  C  C   . TYR   A 1 133 ? 167.079 133.896 194.965 1.00 112.91 ? 182 TYR   A C   1 
ATOM   983  O  O   . TYR   A 1 133 ? 167.814 134.577 194.241 1.00 116.39 ? 182 TYR   A O   1 
ATOM   984  C  CB  . TYR   A 1 133 ? 165.491 132.349 193.807 1.00 109.60 ? 182 TYR   A CB  1 
ATOM   985  C  CG  . TYR   A 1 133 ? 165.399 133.355 192.685 1.00 108.26 ? 182 TYR   A CG  1 
ATOM   986  C  CD1 . TYR   A 1 133 ? 166.354 133.391 191.681 1.00 110.82 ? 182 TYR   A CD1 1 
ATOM   987  C  CD2 . TYR   A 1 133 ? 164.360 134.270 192.630 1.00 112.70 ? 182 TYR   A CD2 1 
ATOM   988  C  CE1 . TYR   A 1 133 ? 166.276 134.309 190.654 1.00 113.89 ? 182 TYR   A CE1 1 
ATOM   989  C  CE2 . TYR   A 1 133 ? 164.273 135.191 191.607 1.00 112.35 ? 182 TYR   A CE2 1 
ATOM   990  C  CZ  . TYR   A 1 133 ? 165.234 135.206 190.622 1.00 112.87 ? 182 TYR   A CZ  1 
ATOM   991  O  OH  . TYR   A 1 133 ? 165.152 136.121 189.599 1.00 111.93 ? 182 TYR   A OH  1 
ATOM   992  N  N   . PHE   A 1 134 ? 166.520 134.394 196.067 1.00 123.29 ? 183 PHE   A N   1 
ATOM   993  C  CA  . PHE   A 1 134 ? 166.731 135.789 196.426 1.00 123.03 ? 183 PHE   A CA  1 
ATOM   994  C  C   . PHE   A 1 134 ? 168.043 136.024 197.163 1.00 125.37 ? 183 PHE   A C   1 
ATOM   995  O  O   . PHE   A 1 134 ? 168.201 137.065 197.812 1.00 128.39 ? 183 PHE   A O   1 
ATOM   996  C  CB  . PHE   A 1 134 ? 165.553 136.308 197.252 1.00 121.95 ? 183 PHE   A CB  1 
ATOM   997  C  CG  . PHE   A 1 134 ? 164.523 137.026 196.433 1.00 118.20 ? 183 PHE   A CG  1 
ATOM   998  C  CD1 . PHE   A 1 134 ? 164.091 136.498 195.231 1.00 120.62 ? 183 PHE   A CD1 1 
ATOM   999  C  CD2 . PHE   A 1 134 ? 164.003 138.234 196.853 1.00 122.15 ? 183 PHE   A CD2 1 
ATOM   1000 C  CE1 . PHE   A 1 134 ? 163.151 137.157 194.468 1.00 124.41 ? 183 PHE   A CE1 1 
ATOM   1001 C  CE2 . PHE   A 1 134 ? 163.063 138.897 196.093 1.00 124.04 ? 183 PHE   A CE2 1 
ATOM   1002 C  CZ  . PHE   A 1 134 ? 162.637 138.357 194.899 1.00 124.23 ? 183 PHE   A CZ  1 
ATOM   1003 N  N   . GLU   A 1 135 ? 168.984 135.082 197.079 1.00 144.17 ? 184 GLU   A N   1 
ATOM   1004 C  CA  . GLU   A 1 135 ? 170.318 135.321 197.615 1.00 144.82 ? 184 GLU   A CA  1 
ATOM   1005 C  C   . GLU   A 1 135 ? 171.122 136.249 196.713 1.00 145.17 ? 184 GLU   A C   1 
ATOM   1006 O  O   . GLU   A 1 135 ? 172.028 136.944 197.188 1.00 141.56 ? 184 GLU   A O   1 
ATOM   1007 C  CB  . GLU   A 1 135 ? 171.050 133.992 197.801 1.00 139.55 ? 184 GLU   A CB  1 
ATOM   1008 C  CG  . GLU   A 1 135 ? 172.357 134.101 198.561 1.00 143.34 ? 184 GLU   A CG  1 
ATOM   1009 C  CD  . GLU   A 1 135 ? 172.178 133.906 200.051 1.00 147.49 ? 184 GLU   A CD  1 
ATOM   1010 O  OE1 . GLU   A 1 135 ? 172.048 132.744 200.487 1.00 148.32 ? 184 GLU   A OE1 1 
ATOM   1011 O  OE2 . GLU   A 1 135 ? 172.163 134.916 200.786 1.00 145.43 ? 184 GLU   A OE2 1 
ATOM   1012 N  N   . SER   A 1 136 ? 170.803 136.280 195.418 1.00 149.83 ? 185 SER   A N   1 
ATOM   1013 C  CA  . SER   A 1 136 ? 171.566 137.074 194.463 1.00 147.74 ? 185 SER   A CA  1 
ATOM   1014 C  C   . SER   A 1 136 ? 171.235 138.558 194.517 1.00 147.08 ? 185 SER   A C   1 
ATOM   1015 O  O   . SER   A 1 136 ? 171.970 139.361 193.932 1.00 148.23 ? 185 SER   A O   1 
ATOM   1016 C  CB  . SER   A 1 136 ? 171.332 136.555 193.043 1.00 147.25 ? 185 SER   A CB  1 
ATOM   1017 O  OG  . SER   A 1 136 ? 171.751 137.507 192.081 1.00 144.29 ? 185 SER   A OG  1 
ATOM   1018 N  N   . TRP   A 1 137 ? 170.152 138.945 195.193 1.00 140.32 ? 186 TRP   A N   1 
ATOM   1019 C  CA  . TRP   A 1 137 ? 169.789 140.356 195.252 1.00 140.65 ? 186 TRP   A CA  1 
ATOM   1020 C  C   . TRP   A 1 137 ? 170.688 141.150 196.190 1.00 142.27 ? 186 TRP   A C   1 
ATOM   1021 O  O   . TRP   A 1 137 ? 170.654 142.384 196.160 1.00 141.84 ? 186 TRP   A O   1 
ATOM   1022 C  CB  . TRP   A 1 137 ? 168.327 140.510 195.672 1.00 135.94 ? 186 TRP   A CB  1 
ATOM   1023 C  CG  . TRP   A 1 137 ? 167.379 140.525 194.515 1.00 135.45 ? 186 TRP   A CG  1 
ATOM   1024 C  CD1 . TRP   A 1 137 ? 167.555 139.921 193.307 1.00 137.95 ? 186 TRP   A CD1 1 
ATOM   1025 C  CD2 . TRP   A 1 137 ? 166.110 141.184 194.453 1.00 139.37 ? 186 TRP   A CD2 1 
ATOM   1026 N  NE1 . TRP   A 1 137 ? 166.472 140.159 192.496 1.00 141.84 ? 186 TRP   A NE1 1 
ATOM   1027 C  CE2 . TRP   A 1 137 ? 165.571 140.933 193.178 1.00 140.07 ? 186 TRP   A CE2 1 
ATOM   1028 C  CE3 . TRP   A 1 137 ? 165.376 141.961 195.354 1.00 143.71 ? 186 TRP   A CE3 1 
ATOM   1029 C  CZ2 . TRP   A 1 137 ? 164.332 141.430 192.780 1.00 137.49 ? 186 TRP   A CZ2 1 
ATOM   1030 C  CZ3 . TRP   A 1 137 ? 164.147 142.454 194.957 1.00 142.33 ? 186 TRP   A CZ3 1 
ATOM   1031 C  CH2 . TRP   A 1 137 ? 163.638 142.187 193.681 1.00 139.01 ? 186 TRP   A CH2 1 
ATOM   1032 N  N   . GLY   A 1 138 ? 171.485 140.480 197.014 1.00 150.26 ? 187 GLY   A N   1 
ATOM   1033 C  CA  . GLY   A 1 138 ? 172.410 141.168 197.885 1.00 146.82 ? 187 GLY   A CA  1 
ATOM   1034 C  C   . GLY   A 1 138 ? 171.722 141.857 199.048 1.00 147.97 ? 187 GLY   A C   1 
ATOM   1035 O  O   . GLY   A 1 138 ? 170.539 141.655 199.332 1.00 153.17 ? 187 GLY   A O   1 
ATOM   1036 N  N   . GLU   A 1 139 ? 172.502 142.694 199.735 1.00 154.33 ? 188 GLU   A N   1 
ATOM   1037 C  CA  . GLU   A 1 139 ? 171.976 143.406 200.895 1.00 156.60 ? 188 GLU   A CA  1 
ATOM   1038 C  C   . GLU   A 1 139 ? 171.050 144.543 200.482 1.00 156.41 ? 188 GLU   A C   1 
ATOM   1039 O  O   . GLU   A 1 139 ? 170.020 144.774 201.125 1.00 158.82 ? 188 GLU   A O   1 
ATOM   1040 C  CB  . GLU   A 1 139 ? 173.127 143.935 201.750 1.00 155.70 ? 188 GLU   A CB  1 
ATOM   1041 C  CG  . GLU   A 1 139 ? 172.912 143.776 203.244 1.00 157.19 ? 188 GLU   A CG  1 
ATOM   1042 C  CD  . GLU   A 1 139 ? 173.019 142.333 203.695 1.00 160.94 ? 188 GLU   A CD  1 
ATOM   1043 O  OE1 . GLU   A 1 139 ? 173.900 141.612 203.182 1.00 160.40 ? 188 GLU   A OE1 1 
ATOM   1044 O  OE2 . GLU   A 1 139 ? 172.223 141.919 204.564 1.00 161.51 ? 188 GLU   A OE2 1 
ATOM   1045 N  N   . SER   A 1 140 ? 171.397 145.264 199.419 1.00 143.36 ? 189 SER   A N   1 
ATOM   1046 C  CA  . SER   A 1 140 ? 170.599 146.403 198.987 1.00 142.82 ? 189 SER   A CA  1 
ATOM   1047 C  C   . SER   A 1 140 ? 170.871 146.670 197.515 1.00 145.06 ? 189 SER   A C   1 
ATOM   1048 O  O   . SER   A 1 140 ? 171.841 146.168 196.943 1.00 152.36 ? 189 SER   A O   1 
ATOM   1049 C  CB  . SER   A 1 140 ? 170.902 147.649 199.823 1.00 147.86 ? 189 SER   A CB  1 
ATOM   1050 O  OG  . SER   A 1 140 ? 172.282 147.729 200.131 1.00 152.14 ? 189 SER   A OG  1 
ATOM   1051 N  N   . GLY   A 1 141 ? 170.000 147.468 196.914 1.00 148.79 ? 190 GLY   A N   1 
ATOM   1052 C  CA  . GLY   A 1 141 ? 170.126 147.859 195.529 1.00 150.85 ? 190 GLY   A CA  1 
ATOM   1053 C  C   . GLY   A 1 141 ? 168.765 147.950 194.879 1.00 151.05 ? 190 GLY   A C   1 
ATOM   1054 O  O   . GLY   A 1 141 ? 167.734 147.992 195.547 1.00 154.75 ? 190 GLY   A O   1 
ATOM   1055 N  N   . GLU   A 1 142 ? 168.768 147.988 193.549 1.00 156.62 ? 191 GLU   A N   1 
ATOM   1056 C  CA  . GLU   A 1 142 ? 167.547 148.043 192.761 1.00 156.17 ? 191 GLU   A CA  1 
ATOM   1057 C  C   . GLU   A 1 142 ? 167.554 146.924 191.731 1.00 157.33 ? 191 GLU   A C   1 
ATOM   1058 O  O   . GLU   A 1 142 ? 168.599 146.581 191.172 1.00 162.76 ? 191 GLU   A O   1 
ATOM   1059 C  CB  . GLU   A 1 142 ? 167.387 149.397 192.059 1.00 158.05 ? 191 GLU   A CB  1 
ATOM   1060 C  CG  . GLU   A 1 142 ? 167.243 150.575 193.006 1.00 157.85 ? 191 GLU   A CG  1 
ATOM   1061 C  CD  . GLU   A 1 142 ? 168.565 151.255 193.300 1.00 161.86 ? 191 GLU   A CD  1 
ATOM   1062 O  OE1 . GLU   A 1 142 ? 169.580 150.544 193.456 1.00 160.74 ? 191 GLU   A OE1 1 
ATOM   1063 O  OE2 . GLU   A 1 142 ? 168.590 152.502 193.375 1.00 163.77 ? 191 GLU   A OE2 1 
ATOM   1064 N  N   . LYS   A 1 143 ? 166.374 146.362 191.481 1.00 135.24 ? 192 LYS   A N   1 
ATOM   1065 C  CA  . LYS   A 1 143 ? 166.241 145.242 190.562 1.00 138.09 ? 192 LYS   A CA  1 
ATOM   1066 C  C   . LYS   A 1 143 ? 164.904 145.339 189.843 1.00 139.13 ? 192 LYS   A C   1 
ATOM   1067 O  O   . LYS   A 1 143 ? 163.997 146.057 190.269 1.00 141.92 ? 192 LYS   A O   1 
ATOM   1068 C  CB  . LYS   A 1 143 ? 166.349 143.894 191.287 1.00 139.77 ? 192 LYS   A CB  1 
ATOM   1069 C  CG  . LYS   A 1 143 ? 167.751 143.524 191.745 1.00 140.76 ? 192 LYS   A CG  1 
ATOM   1070 C  CD  . LYS   A 1 143 ? 168.704 143.385 190.572 1.00 140.86 ? 192 LYS   A CD  1 
ATOM   1071 C  CE  . LYS   A 1 143 ? 170.132 143.194 191.053 1.00 139.91 ? 192 LYS   A CE  1 
ATOM   1072 N  NZ  . LYS   A 1 143 ? 170.755 144.481 191.465 1.00 140.12 ? 192 LYS   A NZ  1 
ATOM   1073 N  N   . ASN   A 1 144 ? 164.796 144.605 188.737 1.00 143.47 ? 193 ASN   A N   1 
ATOM   1074 C  CA  . ASN   A 1 144 ? 163.544 144.506 187.996 1.00 143.28 ? 193 ASN   A CA  1 
ATOM   1075 C  C   . ASN   A 1 144 ? 162.639 143.515 188.713 1.00 147.44 ? 193 ASN   A C   1 
ATOM   1076 O  O   . ASN   A 1 144 ? 162.861 142.302 188.648 1.00 151.00 ? 193 ASN   A O   1 
ATOM   1077 C  CB  . ASN   A 1 144 ? 163.802 144.074 186.556 1.00 142.85 ? 193 ASN   A CB  1 
ATOM   1078 C  CG  . ASN   A 1 144 ? 162.917 144.799 185.564 1.00 144.39 ? 193 ASN   A CG  1 
ATOM   1079 O  OD1 . ASN   A 1 144 ? 162.645 145.989 185.712 1.00 146.76 ? 193 ASN   A OD1 1 
ATOM   1080 N  ND2 . ASN   A 1 144 ? 162.460 144.084 184.545 1.00 146.83 ? 193 ASN   A ND2 1 
ATOM   1081 N  N   . VAL   A 1 145 ? 161.618 144.030 189.402 1.00 143.59 ? 194 VAL   A N   1 
ATOM   1082 C  CA  . VAL   A 1 145 ? 160.780 143.178 190.239 1.00 140.07 ? 194 VAL   A CA  1 
ATOM   1083 C  C   . VAL   A 1 145 ? 160.019 142.170 189.393 1.00 144.13 ? 194 VAL   A C   1 
ATOM   1084 O  O   . VAL   A 1 145 ? 159.933 140.988 189.741 1.00 148.25 ? 194 VAL   A O   1 
ATOM   1085 C  CB  . VAL   A 1 145 ? 159.816 144.034 191.076 1.00 137.37 ? 194 VAL   A CB  1 
ATOM   1086 C  CG1 . VAL   A 1 145 ? 159.049 143.163 192.055 1.00 136.48 ? 194 VAL   A CG1 1 
ATOM   1087 C  CG2 . VAL   A 1 145 ? 160.564 145.125 191.785 1.00 141.13 ? 194 VAL   A CG2 1 
ATOM   1088 N  N   . PHE   A 1 146 ? 159.446 142.620 188.276 1.00 136.96 ? 195 PHE   A N   1 
ATOM   1089 C  CA  . PHE   A 1 146 ? 158.576 141.755 187.488 1.00 129.11 ? 195 PHE   A CA  1 
ATOM   1090 C  C   . PHE   A 1 146 ? 159.340 140.559 186.932 1.00 137.09 ? 195 PHE   A C   1 
ATOM   1091 O  O   . PHE   A 1 146 ? 158.872 139.420 187.018 1.00 142.32 ? 195 PHE   A O   1 
ATOM   1092 C  CB  . PHE   A 1 146 ? 157.925 142.557 186.363 1.00 127.17 ? 195 PHE   A CB  1 
ATOM   1093 C  CG  . PHE   A 1 146 ? 157.287 141.709 185.308 1.00 131.61 ? 195 PHE   A CG  1 
ATOM   1094 C  CD1 . PHE   A 1 146 ? 156.258 140.844 185.627 1.00 134.28 ? 195 PHE   A CD1 1 
ATOM   1095 C  CD2 . PHE   A 1 146 ? 157.715 141.776 183.995 1.00 138.96 ? 195 PHE   A CD2 1 
ATOM   1096 C  CE1 . PHE   A 1 146 ? 155.668 140.060 184.657 1.00 140.78 ? 195 PHE   A CE1 1 
ATOM   1097 C  CE2 . PHE   A 1 146 ? 157.129 140.995 183.020 1.00 139.60 ? 195 PHE   A CE2 1 
ATOM   1098 C  CZ  . PHE   A 1 146 ? 156.105 140.135 183.352 1.00 139.57 ? 195 PHE   A CZ  1 
ATOM   1099 N  N   . GLU   A 1 147 ? 160.532 140.794 186.380 1.00 140.99 ? 196 GLU   A N   1 
ATOM   1100 C  CA  . GLU   A 1 147 ? 161.286 139.697 185.779 1.00 141.63 ? 196 GLU   A CA  1 
ATOM   1101 C  C   . GLU   A 1 147 ? 161.813 138.735 186.837 1.00 142.64 ? 196 GLU   A C   1 
ATOM   1102 O  O   . GLU   A 1 147 ? 161.764 137.512 186.651 1.00 145.57 ? 196 GLU   A O   1 
ATOM   1103 C  CB  . GLU   A 1 147 ? 162.432 140.245 184.931 1.00 139.81 ? 196 GLU   A CB  1 
ATOM   1104 C  CG  . GLU   A 1 147 ? 161.979 141.000 183.692 1.00 143.68 ? 196 GLU   A CG  1 
ATOM   1105 C  CD  . GLU   A 1 147 ? 161.349 140.098 182.648 1.00 146.96 ? 196 GLU   A CD  1 
ATOM   1106 O  OE1 . GLU   A 1 147 ? 161.541 138.866 182.721 1.00 145.82 ? 196 GLU   A OE1 1 
ATOM   1107 O  OE2 . GLU   A 1 147 ? 160.657 140.624 181.750 1.00 145.32 ? 196 GLU   A OE2 1 
ATOM   1108 N  N   . ALA   A 1 148 ? 162.324 139.265 187.951 1.00 125.73 ? 197 ALA   A N   1 
ATOM   1109 C  CA  . ALA   A 1 148 ? 162.814 138.398 189.017 1.00 128.02 ? 197 ALA   A CA  1 
ATOM   1110 C  C   . ALA   A 1 148 ? 161.689 137.552 189.595 1.00 127.02 ? 197 ALA   A C   1 
ATOM   1111 O  O   . ALA   A 1 148 ? 161.864 136.352 189.842 1.00 128.67 ? 197 ALA   A O   1 
ATOM   1112 C  CB  . ALA   A 1 148 ? 163.477 139.232 190.111 1.00 122.86 ? 197 ALA   A CB  1 
ATOM   1113 N  N   . LEU   A 1 149 ? 160.520 138.158 189.807 1.00 119.49 ? 198 LEU   A N   1 
ATOM   1114 C  CA  . LEU   A 1 149 ? 159.383 137.405 190.318 1.00 116.46 ? 198 LEU   A CA  1 
ATOM   1115 C  C   . LEU   A 1 149 ? 158.878 136.392 189.303 1.00 125.87 ? 198 LEU   A C   1 
ATOM   1116 O  O   . LEU   A 1 149 ? 158.451 135.303 189.689 1.00 137.08 ? 198 LEU   A O   1 
ATOM   1117 C  CB  . LEU   A 1 149 ? 158.262 138.355 190.731 1.00 110.00 ? 198 LEU   A CB  1 
ATOM   1118 C  CG  . LEU   A 1 149 ? 158.383 138.874 192.162 1.00 120.65 ? 198 LEU   A CG  1 
ATOM   1119 C  CD1 . LEU   A 1 149 ? 157.340 139.938 192.435 1.00 124.23 ? 198 LEU   A CD1 1 
ATOM   1120 C  CD2 . LEU   A 1 149 ? 158.255 137.727 193.146 1.00 117.20 ? 198 LEU   A CD2 1 
ATOM   1121 N  N   . SER   A 1 150 ? 158.922 136.719 188.009 1.00 121.45 ? 199 SER   A N   1 
ATOM   1122 C  CA  . SER   A 1 150 ? 158.542 135.743 186.993 1.00 121.70 ? 199 SER   A CA  1 
ATOM   1123 C  C   . SER   A 1 150 ? 159.484 134.547 186.999 1.00 119.04 ? 199 SER   A C   1 
ATOM   1124 O  O   . SER   A 1 150 ? 159.044 133.399 186.881 1.00 118.37 ? 199 SER   A O   1 
ATOM   1125 C  CB  . SER   A 1 150 ? 158.521 136.400 185.614 1.00 118.25 ? 199 SER   A CB  1 
ATOM   1126 O  OG  . SER   A 1 150 ? 157.744 135.644 184.703 1.00 119.00 ? 199 SER   A OG  1 
ATOM   1127 N  N   . GLU   A 1 151 ? 160.787 134.798 187.134 1.00 114.34 ? 200 GLU   A N   1 
ATOM   1128 C  CA  . GLU   A 1 151 ? 161.757 133.707 187.156 1.00 116.06 ? 200 GLU   A CA  1 
ATOM   1129 C  C   . GLU   A 1 151 ? 161.562 132.840 188.400 1.00 119.11 ? 200 GLU   A C   1 
ATOM   1130 O  O   . GLU   A 1 151 ? 161.553 131.601 188.323 1.00 117.71 ? 200 GLU   A O   1 
ATOM   1131 C  CB  . GLU   A 1 151 ? 163.167 134.303 187.097 1.00 111.64 ? 200 GLU   A CB  1 
ATOM   1132 C  CG  . GLU   A 1 151 ? 164.319 133.432 187.554 1.00 115.76 ? 200 GLU   A CG  1 
ATOM   1133 C  CD  . GLU   A 1 151 ? 164.357 132.093 186.847 1.00 124.56 ? 200 GLU   A CD  1 
ATOM   1134 O  OE1 . GLU   A 1 151 ? 164.729 131.092 187.483 1.00 120.50 ? 200 GLU   A OE1 1 
ATOM   1135 O  OE2 . GLU   A 1 151 ? 164.023 132.042 185.644 1.00 132.62 ? 200 GLU   A OE2 1 
ATOM   1136 N  N   . LEU   A 1 152 ? 161.359 133.481 189.553 1.00 110.69 ? 201 LEU   A N   1 
ATOM   1137 C  CA  . LEU   A 1 152 ? 161.081 132.741 190.779 1.00 102.23 ? 201 LEU   A CA  1 
ATOM   1138 C  C   . LEU   A 1 152 ? 159.806 131.919 190.653 1.00 108.65 ? 201 LEU   A C   1 
ATOM   1139 O  O   . LEU   A 1 152 ? 159.756 130.762 191.089 1.00 117.51 ? 201 LEU   A O   1 
ATOM   1140 C  CB  . LEU   A 1 152 ? 160.967 133.709 191.952 1.00 101.18 ? 201 LEU   A CB  1 
ATOM   1141 C  CG  . LEU   A 1 152 ? 160.813 133.098 193.341 1.00 108.45 ? 201 LEU   A CG  1 
ATOM   1142 C  CD1 . LEU   A 1 152 ? 161.755 131.922 193.526 1.00 107.49 ? 201 LEU   A CD1 1 
ATOM   1143 C  CD2 . LEU   A 1 152 ? 161.054 134.161 194.390 1.00 112.73 ? 201 LEU   A CD2 1 
ATOM   1144 N  N   . ILE   A 1 153 ? 158.761 132.505 190.071 1.00 101.42 ? 202 ILE   A N   1 
ATOM   1145 C  CA  . ILE   A 1 153 ? 157.477 131.824 189.987 1.00 97.41  ? 202 ILE   A CA  1 
ATOM   1146 C  C   . ILE   A 1 153 ? 157.541 130.668 189.001 1.00 111.04 ? 202 ILE   A C   1 
ATOM   1147 O  O   . ILE   A 1 153 ? 156.925 129.624 189.225 1.00 116.46 ? 202 ILE   A O   1 
ATOM   1148 C  CB  . ILE   A 1 153 ? 156.362 132.829 189.645 1.00 92.02  ? 202 ILE   A CB  1 
ATOM   1149 C  CG1 . ILE   A 1 153 ? 155.857 133.478 190.933 1.00 97.50  ? 202 ILE   A CG1 1 
ATOM   1150 C  CG2 . ILE   A 1 153 ? 155.224 132.159 188.899 1.00 105.23 ? 202 ILE   A CG2 1 
ATOM   1151 C  CD1 . ILE   A 1 153 ? 154.828 134.542 190.722 1.00 101.57 ? 202 ILE   A CD1 1 
ATOM   1152 N  N   . ILE   A 1 154 ? 158.291 130.814 187.907 1.00 116.20 ? 203 ILE   A N   1 
ATOM   1153 C  CA  . ILE   A 1 154 ? 158.415 129.684 186.991 1.00 115.47 ? 203 ILE   A CA  1 
ATOM   1154 C  C   . ILE   A 1 154 ? 159.174 128.544 187.663 1.00 112.53 ? 203 ILE   A C   1 
ATOM   1155 O  O   . ILE   A 1 154 ? 158.780 127.376 187.548 1.00 111.51 ? 203 ILE   A O   1 
ATOM   1156 C  CB  . ILE   A 1 154 ? 159.046 130.107 185.647 1.00 113.03 ? 203 ILE   A CB  1 
ATOM   1157 C  CG1 . ILE   A 1 154 ? 158.992 128.952 184.653 1.00 112.75 ? 203 ILE   A CG1 1 
ATOM   1158 C  CG2 . ILE   A 1 154 ? 160.478 130.539 185.791 1.00 111.22 ? 203 ILE   A CG2 1 
ATOM   1159 C  CD1 . ILE   A 1 154 ? 157.634 128.339 184.528 1.00 108.50 ? 203 ILE   A CD1 1 
ATOM   1160 N  N   . LEU   A 1 155 ? 160.230 128.859 188.427 1.00 105.93 ? 204 LEU   A N   1 
ATOM   1161 C  CA  . LEU   A 1 155 ? 160.914 127.803 189.174 1.00 101.98 ? 204 LEU   A CA  1 
ATOM   1162 C  C   . LEU   A 1 155 ? 159.970 127.111 190.150 1.00 110.21 ? 204 LEU   A C   1 
ATOM   1163 O  O   . LEU   A 1 155 ? 159.896 125.876 190.192 1.00 116.29 ? 204 LEU   A O   1 
ATOM   1164 C  CB  . LEU   A 1 155 ? 162.113 128.359 189.936 1.00 105.64 ? 204 LEU   A CB  1 
ATOM   1165 C  CG  . LEU   A 1 155 ? 163.268 129.018 189.201 1.00 110.08 ? 204 LEU   A CG  1 
ATOM   1166 C  CD1 . LEU   A 1 155 ? 164.137 129.756 190.207 1.00 117.58 ? 204 LEU   A CD1 1 
ATOM   1167 C  CD2 . LEU   A 1 155 ? 164.075 127.985 188.440 1.00 109.56 ? 204 LEU   A CD2 1 
ATOM   1168 N  N   . THR   A 1 156 ? 159.254 127.894 190.962 1.00 109.42 ? 205 THR   A N   1 
ATOM   1169 C  CA  . THR   A 1 156 ? 158.404 127.309 191.994 1.00 106.12 ? 205 THR   A CA  1 
ATOM   1170 C  C   . THR   A 1 156 ? 157.258 126.512 191.386 1.00 115.52 ? 205 THR   A C   1 
ATOM   1171 O  O   . THR   A 1 156 ? 156.933 125.420 191.865 1.00 122.33 ? 205 THR   A O   1 
ATOM   1172 C  CB  . THR   A 1 156 ? 157.863 128.400 192.915 1.00 102.62 ? 205 THR   A CB  1 
ATOM   1173 O  OG1 . THR   A 1 156 ? 157.320 129.464 192.127 1.00 114.07 ? 205 THR   A OG1 1 
ATOM   1174 C  CG2 . THR   A 1 156 ? 158.971 128.945 193.793 1.00 106.55 ? 205 THR   A CG2 1 
ATOM   1175 N  N   . ALA   A 1 157 ? 156.629 127.043 190.335 1.00 114.10 ? 206 ALA   A N   1 
ATOM   1176 C  CA  . ALA   A 1 157 ? 155.540 126.332 189.681 1.00 113.93 ? 206 ALA   A CA  1 
ATOM   1177 C  C   . ALA   A 1 157 ? 156.025 125.026 189.077 1.00 116.57 ? 206 ALA   A C   1 
ATOM   1178 O  O   . ALA   A 1 157 ? 155.361 123.993 189.214 1.00 117.51 ? 206 ALA   A O   1 
ATOM   1179 C  CB  . ALA   A 1 157 ? 154.904 127.218 188.611 1.00 114.73 ? 206 ALA   A CB  1 
ATOM   1180 N  N   . SER   A 1 158 ? 157.185 125.041 188.413 1.00 109.93 ? 207 SER   A N   1 
ATOM   1181 C  CA  . SER   A 1 158 ? 157.731 123.796 187.887 1.00 104.16 ? 207 SER   A CA  1 
ATOM   1182 C  C   . SER   A 1 158 ? 157.961 122.793 189.006 1.00 107.25 ? 207 SER   A C   1 
ATOM   1183 O  O   . SER   A 1 158 ? 157.437 121.674 188.965 1.00 123.16 ? 207 SER   A O   1 
ATOM   1184 C  CB  . SER   A 1 158 ? 159.031 124.070 187.133 1.00 111.28 ? 207 SER   A CB  1 
ATOM   1185 O  OG  . SER   A 1 158 ? 158.771 124.648 185.868 1.00 118.19 ? 207 SER   A OG  1 
ATOM   1186 N  N   . HIS   A 1 159 ? 158.682 123.209 190.051 1.00 107.32 ? 208 HIS   A N   1 
ATOM   1187 C  CA  . HIS   A 1 159 ? 159.040 122.296 191.132 1.00 113.28 ? 208 HIS   A CA  1 
ATOM   1188 C  C   . HIS   A 1 159 ? 157.805 121.709 191.802 1.00 118.57 ? 208 HIS   A C   1 
ATOM   1189 O  O   . HIS   A 1 159 ? 157.780 120.520 192.140 1.00 117.30 ? 208 HIS   A O   1 
ATOM   1190 C  CB  . HIS   A 1 159 ? 159.905 123.028 192.157 1.00 114.99 ? 208 HIS   A CB  1 
ATOM   1191 C  CG  . HIS   A 1 159 ? 160.677 122.121 193.063 1.00 122.58 ? 208 HIS   A CG  1 
ATOM   1192 N  ND1 . HIS   A 1 159 ? 161.798 122.536 193.749 1.00 119.54 ? 208 HIS   A ND1 1 
ATOM   1193 C  CD2 . HIS   A 1 159 ? 160.491 120.823 193.399 1.00 125.13 ? 208 HIS   A CD2 1 
ATOM   1194 C  CE1 . HIS   A 1 159 ? 162.269 121.533 194.468 1.00 124.97 ? 208 HIS   A CE1 1 
ATOM   1195 N  NE2 . HIS   A 1 159 ? 161.494 120.482 194.274 1.00 127.66 ? 208 HIS   A NE2 1 
ATOM   1196 N  N   . CYS   A 1 160 ? 156.769 122.523 192.002 1.00 121.25 ? 209 CYS   A N   1 
ATOM   1197 C  CA  . CYS   A 1 160 ? 155.578 122.045 192.694 1.00 119.25 ? 209 CYS   A CA  1 
ATOM   1198 C  C   . CYS   A 1 160 ? 154.721 121.162 191.794 1.00 118.43 ? 209 CYS   A C   1 
ATOM   1199 O  O   . CYS   A 1 160 ? 154.359 120.042 192.170 1.00 122.22 ? 209 CYS   A O   1 
ATOM   1200 C  CB  . CYS   A 1 160 ? 154.767 123.232 193.218 1.00 119.58 ? 209 CYS   A CB  1 
ATOM   1201 S  SG  . CYS   A 1 160 ? 155.614 124.200 194.480 1.00 126.42 ? 209 CYS   A SG  1 
ATOM   1202 N  N   . LEU   A 1 161 ? 154.386 121.646 190.598 1.00 115.28 ? 210 LEU   A N   1 
ATOM   1203 C  CA  . LEU   A 1 161 ? 153.449 120.926 189.746 1.00 119.56 ? 210 LEU   A CA  1 
ATOM   1204 C  C   . LEU   A 1 161 ? 154.125 119.756 189.039 1.00 118.45 ? 210 LEU   A C   1 
ATOM   1205 O  O   . LEU   A 1 161 ? 153.751 118.595 189.238 1.00 124.47 ? 210 LEU   A O   1 
ATOM   1206 C  CB  . LEU   A 1 161 ? 152.830 121.887 188.731 1.00 119.58 ? 210 LEU   A CB  1 
ATOM   1207 C  CG  . LEU   A 1 161 ? 152.017 123.039 189.322 1.00 122.10 ? 210 LEU   A CG  1 
ATOM   1208 C  CD1 . LEU   A 1 161 ? 151.516 123.959 188.223 1.00 121.08 ? 210 LEU   A CD1 1 
ATOM   1209 C  CD2 . LEU   A 1 161 ? 150.859 122.505 190.145 1.00 125.29 ? 210 LEU   A CD2 1 
ATOM   1210 N  N   . HIS   A 1 162 ? 155.128 120.041 188.205 1.00 103.44 ? 211 HIS   A N   1 
ATOM   1211 C  CA  . HIS   A 1 162 ? 155.643 119.005 187.320 1.00 100.67 ? 211 HIS   A CA  1 
ATOM   1212 C  C   . HIS   A 1 162 ? 156.468 117.973 188.075 1.00 109.45 ? 211 HIS   A C   1 
ATOM   1213 O  O   . HIS   A 1 162 ? 156.490 116.800 187.691 1.00 124.37 ? 211 HIS   A O   1 
ATOM   1214 C  CB  . HIS   A 1 162 ? 156.472 119.637 186.206 1.00 109.85 ? 211 HIS   A CB  1 
ATOM   1215 C  CG  . HIS   A 1 162 ? 155.703 120.593 185.350 1.00 110.71 ? 211 HIS   A CG  1 
ATOM   1216 N  ND1 . HIS   A 1 162 ? 156.287 121.311 184.329 1.00 110.61 ? 211 HIS   A ND1 1 
ATOM   1217 C  CD2 . HIS   A 1 162 ? 154.399 120.954 185.365 1.00 108.41 ? 211 HIS   A CD2 1 
ATOM   1218 C  CE1 . HIS   A 1 162 ? 155.374 122.067 183.748 1.00 108.47 ? 211 HIS   A CE1 1 
ATOM   1219 N  NE2 . HIS   A 1 162 ? 154.220 121.872 184.360 1.00 113.27 ? 211 HIS   A NE2 1 
ATOM   1220 N  N   . GLY   A 1 163 ? 157.144 118.381 189.137 1.00 123.34 ? 212 GLY   A N   1 
ATOM   1221 C  CA  . GLY   A 1 163 ? 157.923 117.473 189.952 1.00 126.64 ? 212 GLY   A CA  1 
ATOM   1222 C  C   . GLY   A 1 163 ? 159.413 117.760 189.868 1.00 133.79 ? 212 GLY   A C   1 
ATOM   1223 O  O   . GLY   A 1 163 ? 159.889 118.560 189.059 1.00 140.78 ? 212 GLY   A O   1 
ATOM   1224 N  N   . LYS   A 1 164 ? 160.145 117.069 190.745 1.00 143.71 ? 213 LYS   A N   1 
ATOM   1225 C  CA  . LYS   A 1 164 ? 161.589 117.255 190.831 1.00 141.79 ? 213 LYS   A CA  1 
ATOM   1226 C  C   . LYS   A 1 164 ? 162.288 116.852 189.541 1.00 143.05 ? 213 LYS   A C   1 
ATOM   1227 O  O   . LYS   A 1 164 ? 163.305 117.452 189.177 1.00 143.40 ? 213 LYS   A O   1 
ATOM   1228 C  CB  . LYS   A 1 164 ? 162.147 116.455 192.007 1.00 141.09 ? 213 LYS   A CB  1 
ATOM   1229 C  CG  . LYS   A 1 164 ? 163.365 117.078 192.663 1.00 144.99 ? 213 LYS   A CG  1 
ATOM   1230 C  CD  . LYS   A 1 164 ? 163.911 116.183 193.764 1.00 148.33 ? 213 LYS   A CD  1 
ATOM   1231 C  CE  . LYS   A 1 164 ? 164.127 114.763 193.263 1.00 144.62 ? 213 LYS   A CE  1 
ATOM   1232 N  NZ  . LYS   A 1 164 ? 164.565 113.848 194.351 1.00 144.97 ? 213 LYS   A NZ  1 
ATOM   1233 N  N   . GLU   A 1 165 ? 161.767 115.840 188.842 1.00 143.25 ? 214 GLU   A N   1 
ATOM   1234 C  CA  . GLU   A 1 165 ? 162.398 115.401 187.602 1.00 144.41 ? 214 GLU   A CA  1 
ATOM   1235 C  C   . GLU   A 1 165 ? 162.397 116.510 186.559 1.00 143.42 ? 214 GLU   A C   1 
ATOM   1236 O  O   . GLU   A 1 165 ? 163.413 116.752 185.898 1.00 143.26 ? 214 GLU   A O   1 
ATOM   1237 C  CB  . GLU   A 1 165 ? 161.688 114.160 187.063 1.00 147.59 ? 214 GLU   A CB  1 
ATOM   1238 C  CG  . GLU   A 1 165 ? 161.521 113.047 188.081 1.00 149.41 ? 214 GLU   A CG  1 
ATOM   1239 C  CD  . GLU   A 1 165 ? 160.066 112.772 188.405 1.00 150.89 ? 214 GLU   A CD  1 
ATOM   1240 O  OE1 . GLU   A 1 165 ? 159.188 113.279 187.676 1.00 148.17 ? 214 GLU   A OE1 1 
ATOM   1241 O  OE2 . GLU   A 1 165 ? 159.799 112.052 189.390 1.00 149.92 ? 214 GLU   A OE2 1 
ATOM   1242 N  N   . ILE   A 1 166 ? 161.263 117.193 186.393 1.00 121.89 ? 215 ILE   A N   1 
ATOM   1243 C  CA  . ILE   A 1 166 ? 161.203 118.299 185.445 1.00 119.37 ? 215 ILE   A CA  1 
ATOM   1244 C  C   . ILE   A 1 166 ? 161.982 119.499 185.970 1.00 126.41 ? 215 ILE   A C   1 
ATOM   1245 O  O   . ILE   A 1 166 ? 162.695 120.169 185.213 1.00 129.12 ? 215 ILE   A O   1 
ATOM   1246 C  CB  . ILE   A 1 166 ? 159.741 118.664 185.133 1.00 115.19 ? 215 ILE   A CB  1 
ATOM   1247 C  CG1 . ILE   A 1 166 ? 159.114 117.620 184.208 1.00 125.35 ? 215 ILE   A CG1 1 
ATOM   1248 C  CG2 . ILE   A 1 166 ? 159.658 120.040 184.496 1.00 117.63 ? 215 ILE   A CG2 1 
ATOM   1249 C  CD1 . ILE   A 1 166 ? 158.450 116.472 184.935 1.00 127.73 ? 215 ILE   A CD1 1 
ATOM   1250 N  N   . ARG   A 1 167 ? 161.867 119.788 187.270 1.00 139.02 ? 216 ARG   A N   1 
ATOM   1251 C  CA  . ARG   A 1 167 ? 162.517 120.977 187.815 1.00 136.57 ? 216 ARG   A CA  1 
ATOM   1252 C  C   . ARG   A 1 167 ? 164.032 120.894 187.682 1.00 140.31 ? 216 ARG   A C   1 
ATOM   1253 O  O   . ARG   A 1 167 ? 164.687 121.885 187.337 1.00 143.52 ? 216 ARG   A O   1 
ATOM   1254 C  CB  . ARG   A 1 167 ? 162.117 121.176 189.277 1.00 132.61 ? 216 ARG   A CB  1 
ATOM   1255 C  CG  . ARG   A 1 167 ? 163.086 122.039 190.068 1.00 129.75 ? 216 ARG   A CG  1 
ATOM   1256 C  CD  . ARG   A 1 167 ? 163.020 123.488 189.613 1.00 129.82 ? 216 ARG   A CD  1 
ATOM   1257 N  NE  . ARG   A 1 167 ? 163.629 124.393 190.579 1.00 137.26 ? 216 ARG   A NE  1 
ATOM   1258 C  CZ  . ARG   A 1 167 ? 164.894 124.790 190.540 1.00 137.38 ? 216 ARG   A CZ  1 
ATOM   1259 N  NH1 . ARG   A 1 167 ? 165.716 124.381 189.588 1.00 135.21 ? 216 ARG   A NH1 1 
ATOM   1260 N  NH2 . ARG   A 1 167 ? 165.344 125.617 191.479 1.00 139.41 ? 216 ARG   A NH2 1 
ATOM   1261 N  N   . SER   A 1 168 ? 164.610 119.721 187.951 1.00 142.54 ? 217 SER   A N   1 
ATOM   1262 C  CA  . SER   A 1 168 ? 166.056 119.567 187.829 1.00 142.90 ? 217 SER   A CA  1 
ATOM   1263 C  C   . SER   A 1 168 ? 166.516 119.810 186.399 1.00 139.53 ? 217 SER   A C   1 
ATOM   1264 O  O   . SER   A 1 168 ? 167.586 120.385 186.171 1.00 140.11 ? 217 SER   A O   1 
ATOM   1265 C  CB  . SER   A 1 168 ? 166.475 118.176 188.302 1.00 141.99 ? 217 SER   A CB  1 
ATOM   1266 O  OG  . SER   A 1 168 ? 166.455 118.092 189.716 1.00 144.58 ? 217 SER   A OG  1 
ATOM   1267 N  N   . GLN   A 1 169 ? 165.718 119.382 185.420 1.00 133.00 ? 218 GLN   A N   1 
ATOM   1268 C  CA  . GLN   A 1 169 ? 166.055 119.603 184.021 1.00 137.86 ? 218 GLN   A CA  1 
ATOM   1269 C  C   . GLN   A 1 169 ? 165.868 121.050 183.588 1.00 132.57 ? 218 GLN   A C   1 
ATOM   1270 O  O   . GLN   A 1 169 ? 166.260 121.396 182.469 1.00 135.01 ? 218 GLN   A O   1 
ATOM   1271 C  CB  . GLN   A 1 169 ? 165.215 118.687 183.130 1.00 136.26 ? 218 GLN   A CB  1 
ATOM   1272 C  CG  . GLN   A 1 169 ? 165.413 117.208 183.405 1.00 134.57 ? 218 GLN   A CG  1 
ATOM   1273 C  CD  . GLN   A 1 169 ? 164.831 116.331 182.317 1.00 135.76 ? 218 GLN   A CD  1 
ATOM   1274 O  OE1 . GLN   A 1 169 ? 164.167 116.817 181.403 1.00 133.07 ? 218 GLN   A OE1 1 
ATOM   1275 N  NE2 . GLN   A 1 169 ? 165.078 115.030 182.409 1.00 138.01 ? 218 GLN   A NE2 1 
ATOM   1276 N  N   . LEU   A 1 170 ? 165.283 121.895 184.432 1.00 131.49 ? 219 LEU   A N   1 
ATOM   1277 C  CA  . LEU   A 1 170 ? 165.023 123.277 184.050 1.00 140.80 ? 219 LEU   A CA  1 
ATOM   1278 C  C   . LEU   A 1 170 ? 166.324 124.068 184.005 1.00 143.43 ? 219 LEU   A C   1 
ATOM   1279 O  O   . LEU   A 1 170 ? 167.112 124.042 184.956 1.00 145.72 ? 219 LEU   A O   1 
ATOM   1280 C  CB  . LEU   A 1 170 ? 164.036 123.922 185.019 1.00 140.57 ? 219 LEU   A CB  1 
ATOM   1281 C  CG  . LEU   A 1 170 ? 163.228 125.098 184.467 1.00 139.85 ? 219 LEU   A CG  1 
ATOM   1282 C  CD1 . LEU   A 1 170 ? 161.857 125.145 185.105 1.00 139.51 ? 219 LEU   A CD1 1 
ATOM   1283 C  CD2 . LEU   A 1 170 ? 163.958 126.413 184.683 1.00 139.62 ? 219 LEU   A CD2 1 
ATOM   1284 N  N   . ASN   A 1 171 ? 166.544 124.769 182.894 1.00 155.48 ? 220 ASN   A N   1 
ATOM   1285 C  CA  . ASN   A 1 171 ? 167.687 125.657 182.735 1.00 153.41 ? 220 ASN   A CA  1 
ATOM   1286 C  C   . ASN   A 1 171 ? 167.261 126.933 182.020 1.00 154.22 ? 220 ASN   A C   1 
ATOM   1287 O  O   . ASN   A 1 171 ? 166.067 127.152 181.787 1.00 156.73 ? 220 ASN   A O   1 
ATOM   1288 C  CB  . ASN   A 1 171 ? 168.810 124.960 181.966 1.00 150.87 ? 220 ASN   A CB  1 
ATOM   1289 C  CG  . ASN   A 1 171 ? 168.472 124.754 180.504 1.00 152.28 ? 220 ASN   A CG  1 
ATOM   1290 O  OD1 . ASN   A 1 171 ? 167.312 124.552 180.145 1.00 153.63 ? 220 ASN   A OD1 1 
ATOM   1291 N  ND2 . ASN   A 1 171 ? 169.486 124.807 179.650 1.00 154.15 ? 220 ASN   A ND2 1 
ATOM   1292 N  N   . GLU   A 1 172 ? 168.232 127.778 181.664 1.00 169.14 ? 221 GLU   A N   1 
ATOM   1293 C  CA  . GLU   A 1 172 ? 167.909 129.022 180.973 1.00 171.23 ? 221 GLU   A CA  1 
ATOM   1294 C  C   . GLU   A 1 172 ? 167.302 128.764 179.600 1.00 173.11 ? 221 GLU   A C   1 
ATOM   1295 O  O   . GLU   A 1 172 ? 166.418 129.509 179.165 1.00 174.39 ? 221 GLU   A O   1 
ATOM   1296 C  CB  . GLU   A 1 172 ? 169.159 129.893 180.847 1.00 171.22 ? 221 GLU   A CB  1 
ATOM   1297 C  CG  . GLU   A 1 172 ? 169.644 130.484 182.163 1.00 172.02 ? 221 GLU   A CG  1 
ATOM   1298 C  CD  . GLU   A 1 172 ? 170.600 129.569 182.905 1.00 173.53 ? 221 GLU   A CD  1 
ATOM   1299 O  OE1 . GLU   A 1 172 ? 170.360 128.344 182.931 1.00 174.28 ? 221 GLU   A OE1 1 
ATOM   1300 O  OE2 . GLU   A 1 172 ? 171.593 130.078 183.465 1.00 170.30 ? 221 GLU   A OE2 1 
ATOM   1301 N  N   . LYS   A 1 173 ? 167.758 127.718 178.907 1.00 159.37 ? 222 LYS   A N   1 
ATOM   1302 C  CA  . LYS   A 1 173 ? 167.218 127.415 177.585 1.00 157.12 ? 222 LYS   A CA  1 
ATOM   1303 C  C   . LYS   A 1 173 ? 165.734 127.074 177.661 1.00 155.57 ? 222 LYS   A C   1 
ATOM   1304 O  O   . LYS   A 1 173 ? 164.922 127.601 176.893 1.00 154.94 ? 222 LYS   A O   1 
ATOM   1305 C  CB  . LYS   A 1 173 ? 168.008 126.270 176.950 1.00 156.36 ? 222 LYS   A CB  1 
ATOM   1306 C  CG  . LYS   A 1 173 ? 167.239 125.490 175.896 1.00 157.94 ? 222 LYS   A CG  1 
ATOM   1307 C  CD  . LYS   A 1 173 ? 168.158 124.568 175.109 1.00 158.34 ? 222 LYS   A CD  1 
ATOM   1308 C  CE  . LYS   A 1 173 ? 168.976 123.676 176.030 1.00 158.70 ? 222 LYS   A CE  1 
ATOM   1309 N  NZ  . LYS   A 1 173 ? 168.117 122.906 176.970 1.00 158.28 ? 222 LYS   A NZ  1 
ATOM   1310 N  N   . VAL   A 1 174 ? 165.352 126.212 178.603 1.00 144.02 ? 223 VAL   A N   1 
ATOM   1311 C  CA  . VAL   A 1 174 ? 163.944 125.843 178.696 1.00 141.67 ? 223 VAL   A CA  1 
ATOM   1312 C  C   . VAL   A 1 174 ? 163.124 126.970 179.322 1.00 142.94 ? 223 VAL   A C   1 
ATOM   1313 O  O   . VAL   A 1 174 ? 161.927 127.092 179.045 1.00 144.88 ? 223 VAL   A O   1 
ATOM   1314 C  CB  . VAL   A 1 174 ? 163.781 124.521 179.466 1.00 144.57 ? 223 VAL   A CB  1 
ATOM   1315 C  CG1 . VAL   A 1 174 ? 164.076 124.719 180.927 1.00 145.28 ? 223 VAL   A CG1 1 
ATOM   1316 C  CG2 . VAL   A 1 174 ? 162.385 123.957 179.274 1.00 145.81 ? 223 VAL   A CG2 1 
ATOM   1317 N  N   . ALA   A 1 175 ? 163.735 127.813 180.158 1.00 153.17 ? 224 ALA   A N   1 
ATOM   1318 C  CA  . ALA   A 1 175 ? 163.026 128.996 180.640 1.00 153.56 ? 224 ALA   A CA  1 
ATOM   1319 C  C   . ALA   A 1 175 ? 162.697 129.939 179.489 1.00 153.55 ? 224 ALA   A C   1 
ATOM   1320 O  O   . ALA   A 1 175 ? 161.583 130.472 179.405 1.00 151.59 ? 224 ALA   A O   1 
ATOM   1321 C  CB  . ALA   A 1 175 ? 163.854 129.710 181.706 1.00 154.04 ? 224 ALA   A CB  1 
ATOM   1322 N  N   . GLN   A 1 176 ? 163.656 130.148 178.584 1.00 155.33 ? 225 GLN   A N   1 
ATOM   1323 C  CA  . GLN   A 1 176 ? 163.382 130.924 177.382 1.00 155.57 ? 225 GLN   A CA  1 
ATOM   1324 C  C   . GLN   A 1 176 ? 162.357 130.227 176.499 1.00 156.83 ? 225 GLN   A C   1 
ATOM   1325 O  O   . GLN   A 1 176 ? 161.554 130.892 175.838 1.00 156.85 ? 225 GLN   A O   1 
ATOM   1326 C  CB  . GLN   A 1 176 ? 164.681 131.173 176.613 1.00 154.98 ? 225 GLN   A CB  1 
ATOM   1327 C  CG  . GLN   A 1 176 ? 164.486 131.741 175.218 1.00 157.98 ? 225 GLN   A CG  1 
ATOM   1328 C  CD  . GLN   A 1 176 ? 165.290 133.003 174.988 1.00 158.53 ? 225 GLN   A CD  1 
ATOM   1329 O  OE1 . GLN   A 1 176 ? 165.729 133.654 175.936 1.00 156.80 ? 225 GLN   A OE1 1 
ATOM   1330 N  NE2 . GLN   A 1 176 ? 165.486 133.358 173.724 1.00 159.46 ? 225 GLN   A NE2 1 
ATOM   1331 N  N   . LEU   A 1 177 ? 162.362 128.892 176.482 1.00 145.34 ? 226 LEU   A N   1 
ATOM   1332 C  CA  . LEU   A 1 177 ? 161.338 128.158 175.744 1.00 144.36 ? 226 LEU   A CA  1 
ATOM   1333 C  C   . LEU   A 1 177 ? 159.949 128.431 176.308 1.00 144.25 ? 226 LEU   A C   1 
ATOM   1334 O  O   . LEU   A 1 177 ? 158.989 128.617 175.552 1.00 146.34 ? 226 LEU   A O   1 
ATOM   1335 C  CB  . LEU   A 1 177 ? 161.641 126.661 175.776 1.00 141.91 ? 226 LEU   A CB  1 
ATOM   1336 C  CG  . LEU   A 1 177 ? 161.401 125.894 174.476 1.00 143.86 ? 226 LEU   A CG  1 
ATOM   1337 C  CD1 . LEU   A 1 177 ? 161.988 126.648 173.294 1.00 144.89 ? 226 LEU   A CD1 1 
ATOM   1338 C  CD2 . LEU   A 1 177 ? 161.981 124.492 174.566 1.00 141.75 ? 226 LEU   A CD2 1 
ATOM   1339 N  N   . TYR   A 1 178 ? 159.821 128.444 177.635 1.00 131.26 ? 227 TYR   A N   1 
ATOM   1340 C  CA  . TYR   A 1 178 ? 158.539 128.762 178.260 1.00 125.19 ? 227 TYR   A CA  1 
ATOM   1341 C  C   . TYR   A 1 178 ? 158.126 130.199 177.970 1.00 124.25 ? 227 TYR   A C   1 
ATOM   1342 O  O   . TYR   A 1 178 ? 156.946 130.477 177.721 1.00 125.90 ? 227 TYR   A O   1 
ATOM   1343 C  CB  . TYR   A 1 178 ? 158.610 128.521 179.766 1.00 124.41 ? 227 TYR   A CB  1 
ATOM   1344 C  CG  . TYR   A 1 178 ? 158.173 127.139 180.187 1.00 122.89 ? 227 TYR   A CG  1 
ATOM   1345 C  CD1 . TYR   A 1 178 ? 157.025 126.565 179.663 1.00 123.01 ? 227 TYR   A CD1 1 
ATOM   1346 C  CD2 . TYR   A 1 178 ? 158.905 126.410 181.112 1.00 124.87 ? 227 TYR   A CD2 1 
ATOM   1347 C  CE1 . TYR   A 1 178 ? 156.621 125.303 180.043 1.00 129.25 ? 227 TYR   A CE1 1 
ATOM   1348 C  CE2 . TYR   A 1 178 ? 158.509 125.148 181.500 1.00 122.54 ? 227 TYR   A CE2 1 
ATOM   1349 C  CZ  . TYR   A 1 178 ? 157.366 124.599 180.963 1.00 130.11 ? 227 TYR   A CZ  1 
ATOM   1350 O  OH  . TYR   A 1 178 ? 156.966 123.340 181.348 1.00 137.72 ? 227 TYR   A OH  1 
ATOM   1351 N  N   . ALA   A 1 179 ? 159.084 131.127 178.007 1.00 138.77 ? 228 ALA   A N   1 
ATOM   1352 C  CA  . ALA   A 1 179 ? 158.781 132.512 177.660 1.00 143.32 ? 228 ALA   A CA  1 
ATOM   1353 C  C   . ALA   A 1 179 ? 158.295 132.621 176.220 1.00 144.78 ? 228 ALA   A C   1 
ATOM   1354 O  O   . ALA   A 1 179 ? 157.354 133.366 175.926 1.00 147.00 ? 228 ALA   A O   1 
ATOM   1355 C  CB  . ALA   A 1 179 ? 160.010 133.392 177.882 1.00 141.60 ? 228 ALA   A CB  1 
ATOM   1356 N  N   . ASP   A 1 180 ? 158.928 131.882 175.308 1.00 146.01 ? 229 ASP   A N   1 
ATOM   1357 C  CA  . ASP   A 1 180 ? 158.502 131.869 173.913 1.00 145.77 ? 229 ASP   A CA  1 
ATOM   1358 C  C   . ASP   A 1 180 ? 157.110 131.266 173.765 1.00 142.37 ? 229 ASP   A C   1 
ATOM   1359 O  O   . ASP   A 1 180 ? 156.295 131.761 172.978 1.00 146.72 ? 229 ASP   A O   1 
ATOM   1360 C  CB  . ASP   A 1 180 ? 159.520 131.099 173.074 1.00 146.14 ? 229 ASP   A CB  1 
ATOM   1361 C  CG  . ASP   A 1 180 ? 159.154 131.046 171.607 1.00 149.60 ? 229 ASP   A CG  1 
ATOM   1362 O  OD1 . ASP   A 1 180 ? 158.396 131.922 171.139 1.00 148.96 ? 229 ASP   A OD1 1 
ATOM   1363 O  OD2 . ASP   A 1 180 ? 159.636 130.125 170.918 1.00 151.97 ? 229 ASP   A OD2 1 
ATOM   1364 N  N   . LEU   A 1 181 ? 156.825 130.193 174.506 1.00 123.15 ? 230 LEU   A N   1 
ATOM   1365 C  CA  . LEU   A 1 181 ? 155.487 129.613 174.484 1.00 124.31 ? 230 LEU   A CA  1 
ATOM   1366 C  C   . LEU   A 1 181 ? 154.450 130.630 174.933 1.00 129.83 ? 230 LEU   A C   1 
ATOM   1367 O  O   . LEU   A 1 181 ? 153.383 130.757 174.320 1.00 134.95 ? 230 LEU   A O   1 
ATOM   1368 C  CB  . LEU   A 1 181 ? 155.430 128.374 175.375 1.00 127.72 ? 230 LEU   A CB  1 
ATOM   1369 C  CG  . LEU   A 1 181 ? 155.774 127.026 174.745 1.00 130.11 ? 230 LEU   A CG  1 
ATOM   1370 C  CD1 . LEU   A 1 181 ? 156.040 126.000 175.828 1.00 132.34 ? 230 LEU   A CD1 1 
ATOM   1371 C  CD2 . LEU   A 1 181 ? 154.659 126.562 173.829 1.00 129.58 ? 230 LEU   A CD2 1 
ATOM   1372 N  N   . ASP   A 1 182 ? 154.746 131.366 176.006 1.00 147.57 ? 231 ASP   A N   1 
ATOM   1373 C  CA  . ASP   A 1 182 ? 153.861 132.446 176.423 1.00 148.95 ? 231 ASP   A CA  1 
ATOM   1374 C  C   . ASP   A 1 182 ? 153.807 133.565 175.392 1.00 145.68 ? 231 ASP   A C   1 
ATOM   1375 O  O   . ASP   A 1 182 ? 152.826 134.316 175.357 1.00 143.26 ? 231 ASP   A O   1 
ATOM   1376 C  CB  . ASP   A 1 182 ? 154.302 132.996 177.779 1.00 147.13 ? 231 ASP   A CB  1 
ATOM   1377 C  CG  . ASP   A 1 182 ? 153.134 133.455 178.626 1.00 148.22 ? 231 ASP   A CG  1 
ATOM   1378 O  OD1 . ASP   A 1 182 ? 152.140 133.946 178.051 1.00 148.32 ? 231 ASP   A OD1 1 
ATOM   1379 O  OD2 . ASP   A 1 182 ? 153.202 133.316 179.864 1.00 150.24 ? 231 ASP   A OD2 1 
ATOM   1380 N  N   . GLY   A 1 183 ? 154.833 133.687 174.549 1.00 145.22 ? 232 GLY   A N   1 
ATOM   1381 C  CA  . GLY   A 1 183 ? 154.804 134.663 173.475 1.00 143.97 ? 232 GLY   A CA  1 
ATOM   1382 C  C   . GLY   A 1 183 ? 153.770 134.367 172.411 1.00 145.69 ? 232 GLY   A C   1 
ATOM   1383 O  O   . GLY   A 1 183 ? 153.441 135.256 171.619 1.00 149.52 ? 232 GLY   A O   1 
ATOM   1384 N  N   . GLY   A 1 184 ? 153.257 133.136 172.370 1.00 148.61 ? 233 GLY   A N   1 
ATOM   1385 C  CA  . GLY   A 1 184 ? 152.179 132.823 171.449 1.00 148.26 ? 233 GLY   A CA  1 
ATOM   1386 C  C   . GLY   A 1 184 ? 150.917 133.610 171.734 1.00 152.27 ? 233 GLY   A C   1 
ATOM   1387 O  O   . GLY   A 1 184 ? 150.147 133.912 170.818 1.00 155.39 ? 233 GLY   A O   1 
ATOM   1388 N  N   . PHE   A 1 185 ? 150.684 133.949 172.999 1.00 147.87 ? 234 PHE   A N   1 
ATOM   1389 C  CA  . PHE   A 1 185 ? 149.553 134.789 173.384 1.00 147.13 ? 234 PHE   A CA  1 
ATOM   1390 C  C   . PHE   A 1 185 ? 149.941 136.242 173.150 1.00 147.03 ? 234 PHE   A C   1 
ATOM   1391 O  O   . PHE   A 1 185 ? 150.595 136.868 173.987 1.00 148.63 ? 234 PHE   A O   1 
ATOM   1392 C  CB  . PHE   A 1 185 ? 149.170 134.548 174.839 1.00 152.50 ? 234 PHE   A CB  1 
ATOM   1393 C  CG  . PHE   A 1 185 ? 148.786 133.131 175.140 1.00 149.14 ? 234 PHE   A CG  1 
ATOM   1394 C  CD1 . PHE   A 1 185 ? 147.692 132.551 174.525 1.00 147.27 ? 234 PHE   A CD1 1 
ATOM   1395 C  CD2 . PHE   A 1 185 ? 149.514 132.381 176.047 1.00 147.27 ? 234 PHE   A CD2 1 
ATOM   1396 C  CE1 . PHE   A 1 185 ? 147.334 131.250 174.805 1.00 150.72 ? 234 PHE   A CE1 1 
ATOM   1397 C  CE2 . PHE   A 1 185 ? 149.161 131.078 176.329 1.00 147.62 ? 234 PHE   A CE2 1 
ATOM   1398 C  CZ  . PHE   A 1 185 ? 148.069 130.513 175.709 1.00 151.20 ? 234 PHE   A CZ  1 
ATOM   1399 N  N   . SER   A 1 186 ? 149.537 136.782 172.005 1.00 155.09 ? 235 SER   A N   1 
ATOM   1400 C  CA  . SER   A 1 186 ? 149.825 138.165 171.650 1.00 158.27 ? 235 SER   A CA  1 
ATOM   1401 C  C   . SER   A 1 186 ? 148.772 138.621 170.648 1.00 159.83 ? 235 SER   A C   1 
ATOM   1402 O  O   . SER   A 1 186 ? 147.813 137.901 170.358 1.00 158.95 ? 235 SER   A O   1 
ATOM   1403 C  CB  . SER   A 1 186 ? 151.243 138.313 171.093 1.00 153.84 ? 235 SER   A CB  1 
ATOM   1404 O  OG  . SER   A 1 186 ? 151.257 138.162 169.685 1.00 155.60 ? 235 SER   A OG  1 
ATOM   1405 N  N   . HIS   A 1 187 ? 148.961 139.832 170.117 1.00 157.02 ? 236 HIS   A N   1 
ATOM   1406 C  CA  . HIS   A 1 187 ? 147.995 140.383 169.171 1.00 155.80 ? 236 HIS   A CA  1 
ATOM   1407 C  C   . HIS   A 1 187 ? 147.881 139.511 167.928 1.00 156.04 ? 236 HIS   A C   1 
ATOM   1408 O  O   . HIS   A 1 187 ? 146.770 139.212 167.472 1.00 155.74 ? 236 HIS   A O   1 
ATOM   1409 C  CB  . HIS   A 1 187 ? 148.388 141.808 168.789 1.00 158.62 ? 236 HIS   A CB  1 
ATOM   1410 C  CG  . HIS   A 1 187 ? 148.242 142.796 169.904 1.00 158.79 ? 236 HIS   A CG  1 
ATOM   1411 N  ND1 . HIS   A 1 187 ? 147.821 142.438 171.166 1.00 158.25 ? 236 HIS   A ND1 1 
ATOM   1412 C  CD2 . HIS   A 1 187 ? 148.461 144.132 169.945 1.00 158.48 ? 236 HIS   A CD2 1 
ATOM   1413 C  CE1 . HIS   A 1 187 ? 147.787 143.510 171.937 1.00 159.06 ? 236 HIS   A CE1 1 
ATOM   1414 N  NE2 . HIS   A 1 187 ? 148.170 144.551 171.220 1.00 161.08 ? 236 HIS   A NE2 1 
ATOM   1415 N  N   . ALA   A 1 188 ? 149.020 139.058 167.398 1.00 154.52 ? 237 ALA   A N   1 
ATOM   1416 C  CA  . ALA   A 1 188 ? 149.016 138.251 166.183 1.00 155.93 ? 237 ALA   A CA  1 
ATOM   1417 C  C   . ALA   A 1 188 ? 148.136 137.017 166.330 1.00 157.69 ? 237 ALA   A C   1 
ATOM   1418 O  O   . ALA   A 1 188 ? 147.519 136.572 165.357 1.00 158.38 ? 237 ALA   A O   1 
ATOM   1419 C  CB  . ALA   A 1 188 ? 150.445 137.848 165.818 1.00 156.69 ? 237 ALA   A CB  1 
ATOM   1420 N  N   . ALA   A 1 189 ? 148.042 136.469 167.543 1.00 154.42 ? 238 ALA   A N   1 
ATOM   1421 C  CA  . ALA   A 1 189 ? 147.196 135.299 167.759 1.00 152.58 ? 238 ALA   A CA  1 
ATOM   1422 C  C   . ALA   A 1 189 ? 145.740 135.602 167.428 1.00 154.48 ? 238 ALA   A C   1 
ATOM   1423 O  O   . ALA   A 1 189 ? 145.060 134.792 166.787 1.00 154.22 ? 238 ALA   A O   1 
ATOM   1424 C  CB  . ALA   A 1 189 ? 147.331 134.812 169.200 1.00 150.58 ? 238 ALA   A CB  1 
ATOM   1425 N  N   . TRP   A 1 190 ? 145.243 136.765 167.851 1.00 155.49 ? 239 TRP   A N   1 
ATOM   1426 C  CA  . TRP   A 1 190 ? 143.876 137.153 167.514 1.00 155.57 ? 239 TRP   A CA  1 
ATOM   1427 C  C   . TRP   A 1 190 ? 143.765 137.625 166.069 1.00 157.66 ? 239 TRP   A C   1 
ATOM   1428 O  O   . TRP   A 1 190 ? 143.057 137.017 165.259 1.00 156.06 ? 239 TRP   A O   1 
ATOM   1429 C  CB  . TRP   A 1 190 ? 143.379 138.235 168.474 1.00 158.56 ? 239 TRP   A CB  1 
ATOM   1430 C  CG  . TRP   A 1 190 ? 142.881 137.711 169.784 1.00 159.70 ? 239 TRP   A CG  1 
ATOM   1431 C  CD1 . TRP   A 1 190 ? 141.638 137.211 170.038 1.00 157.04 ? 239 TRP   A CD1 1 
ATOM   1432 C  CD2 . TRP   A 1 190 ? 143.603 137.634 171.018 1.00 160.73 ? 239 TRP   A CD2 1 
ATOM   1433 N  NE1 . TRP   A 1 190 ? 141.538 136.831 171.353 1.00 156.05 ? 239 TRP   A NE1 1 
ATOM   1434 C  CE2 . TRP   A 1 190 ? 142.731 137.080 171.977 1.00 158.87 ? 239 TRP   A CE2 1 
ATOM   1435 C  CE3 . TRP   A 1 190 ? 144.899 137.980 171.406 1.00 157.37 ? 239 TRP   A CE3 1 
ATOM   1436 C  CZ2 . TRP   A 1 190 ? 143.115 136.863 173.296 1.00 155.53 ? 239 TRP   A CZ2 1 
ATOM   1437 C  CZ3 . TRP   A 1 190 ? 145.277 137.760 172.716 1.00 155.53 ? 239 TRP   A CZ3 1 
ATOM   1438 C  CH2 . TRP   A 1 190 ? 144.388 137.209 173.644 1.00 156.64 ? 239 TRP   A CH2 1 
ATOM   1439 N  N   . LEU   A 1 191 ? 144.456 138.715 165.724 1.00 154.46 ? 240 LEU   A N   1 
ATOM   1440 C  CA  . LEU   A 1 191 ? 144.243 139.314 164.407 1.00 152.81 ? 240 LEU   A CA  1 
ATOM   1441 C  C   . LEU   A 1 191 ? 144.739 138.413 163.280 1.00 153.86 ? 240 LEU   A C   1 
ATOM   1442 O  O   . LEU   A 1 191 ? 143.997 138.129 162.333 1.00 153.97 ? 240 LEU   A O   1 
ATOM   1443 C  CB  . LEU   A 1 191 ? 144.884 140.703 164.313 1.00 150.11 ? 240 LEU   A CB  1 
ATOM   1444 C  CG  . LEU   A 1 191 ? 144.585 141.829 165.315 1.00 152.13 ? 240 LEU   A CG  1 
ATOM   1445 C  CD1 . LEU   A 1 191 ? 145.186 141.640 166.693 1.00 151.76 ? 240 LEU   A CD1 1 
ATOM   1446 C  CD2 . LEU   A 1 191 ? 145.016 143.169 164.726 1.00 155.18 ? 240 LEU   A CD2 1 
ATOM   1447 N  N   . LEU   A 1 192 ? 145.963 137.951 163.362 1.00 153.35 ? 241 LEU   A N   1 
ATOM   1448 C  CA  . LEU   A 1 192 ? 146.389 137.221 162.178 1.00 152.03 ? 241 LEU   A CA  1 
ATOM   1449 C  C   . LEU   A 1 192 ? 146.057 135.738 162.304 1.00 150.50 ? 241 LEU   A C   1 
ATOM   1450 O  O   . LEU   A 1 192 ? 146.060 135.184 163.407 1.00 151.48 ? 241 LEU   A O   1 
ATOM   1451 C  CB  . LEU   A 1 192 ? 147.888 137.405 161.951 1.00 152.33 ? 241 LEU   A CB  1 
ATOM   1452 C  CG  . LEU   A 1 192 ? 148.501 138.730 162.410 1.00 153.82 ? 241 LEU   A CG  1 
ATOM   1453 C  CD1 . LEU   A 1 192 ? 149.984 138.754 162.108 1.00 153.92 ? 241 LEU   A CD1 1 
ATOM   1454 C  CD2 . LEU   A 1 192 ? 147.818 139.912 161.730 1.00 153.78 ? 241 LEU   A CD2 1 
ATOM   1455 N  N   . PRO   A 1 193 ? 145.768 135.073 161.191 1.00 145.80 ? 242 PRO   A N   1 
ATOM   1456 C  CA  . PRO   A 1 193 ? 145.320 133.680 161.249 1.00 148.34 ? 242 PRO   A CA  1 
ATOM   1457 C  C   . PRO   A 1 193 ? 146.485 132.713 161.408 1.00 146.69 ? 242 PRO   A C   1 
ATOM   1458 O  O   . PRO   A 1 193 ? 147.659 133.078 161.330 1.00 147.81 ? 242 PRO   A O   1 
ATOM   1459 C  CB  . PRO   A 1 193 ? 144.622 133.486 159.901 1.00 144.86 ? 242 PRO   A CB  1 
ATOM   1460 C  CG  . PRO   A 1 193 ? 145.356 134.400 158.988 1.00 144.80 ? 242 PRO   A CG  1 
ATOM   1461 C  CD  . PRO   A 1 193 ? 145.755 135.597 159.814 1.00 145.22 ? 242 PRO   A CD  1 
ATOM   1462 N  N   . GLY   A 1 194 ? 146.129 131.450 161.632 1.00 158.22 ? 243 GLY   A N   1 
ATOM   1463 C  CA  . GLY   A 1 194 ? 147.101 130.380 161.728 1.00 158.65 ? 243 GLY   A CA  1 
ATOM   1464 C  C   . GLY   A 1 194 ? 147.518 129.849 160.372 1.00 161.32 ? 243 GLY   A C   1 
ATOM   1465 O  O   . GLY   A 1 194 ? 147.665 128.638 160.183 1.00 160.68 ? 243 GLY   A O   1 
ATOM   1466 N  N   . TRP   A 1 195 ? 147.708 130.756 159.419 1.00 172.80 ? 244 TRP   A N   1 
ATOM   1467 C  CA  . TRP   A 1 195 ? 148.140 130.429 158.066 1.00 173.28 ? 244 TRP   A CA  1 
ATOM   1468 C  C   . TRP   A 1 195 ? 149.517 130.977 157.732 1.00 172.46 ? 244 TRP   A C   1 
ATOM   1469 O  O   . TRP   A 1 195 ? 150.304 130.298 157.070 1.00 172.16 ? 244 TRP   A O   1 
ATOM   1470 C  CB  . TRP   A 1 195 ? 147.123 130.963 157.050 1.00 170.31 ? 244 TRP   A CB  1 
ATOM   1471 C  CG  . TRP   A 1 195 ? 147.484 130.690 155.626 1.00 170.75 ? 244 TRP   A CG  1 
ATOM   1472 C  CD1 . TRP   A 1 195 ? 147.820 131.610 154.677 1.00 170.33 ? 244 TRP   A CD1 1 
ATOM   1473 C  CD2 . TRP   A 1 195 ? 147.537 129.411 154.982 1.00 172.74 ? 244 TRP   A CD2 1 
ATOM   1474 N  NE1 . TRP   A 1 195 ? 148.084 130.984 153.483 1.00 174.15 ? 244 TRP   A NE1 1 
ATOM   1475 C  CE2 . TRP   A 1 195 ? 147.918 129.633 153.644 1.00 174.34 ? 244 TRP   A CE2 1 
ATOM   1476 C  CE3 . TRP   A 1 195 ? 147.303 128.100 155.407 1.00 170.57 ? 244 TRP   A CE3 1 
ATOM   1477 C  CZ2 . TRP   A 1 195 ? 148.069 128.594 152.728 1.00 171.15 ? 244 TRP   A CZ2 1 
ATOM   1478 C  CZ3 . TRP   A 1 195 ? 147.454 127.070 154.496 1.00 170.39 ? 244 TRP   A CZ3 1 
ATOM   1479 C  CH2 . TRP   A 1 195 ? 147.833 127.323 153.172 1.00 168.89 ? 244 TRP   A CH2 1 
ATOM   1480 N  N   . LEU   A 1 196 ? 149.825 132.184 158.179 1.00 160.32 ? 245 LEU   A N   1 
ATOM   1481 C  CA  . LEU   A 1 196 ? 151.108 132.805 157.882 1.00 161.14 ? 245 LEU   A CA  1 
ATOM   1482 C  C   . LEU   A 1 196 ? 152.208 132.168 158.724 1.00 161.31 ? 245 LEU   A C   1 
ATOM   1483 O  O   . LEU   A 1 196 ? 152.045 132.026 159.939 1.00 161.00 ? 245 LEU   A O   1 
ATOM   1484 C  CB  . LEU   A 1 196 ? 151.045 134.305 158.153 1.00 160.39 ? 245 LEU   A CB  1 
ATOM   1485 C  CG  . LEU   A 1 196 ? 152.377 135.002 158.427 1.00 159.68 ? 245 LEU   A CG  1 
ATOM   1486 C  CD1 . LEU   A 1 196 ? 153.073 135.348 157.121 1.00 161.20 ? 245 LEU   A CD1 1 
ATOM   1487 C  CD2 . LEU   A 1 196 ? 152.165 136.243 159.279 1.00 159.10 ? 245 LEU   A CD2 1 
ATOM   1488 N  N   . PRO   A 1 197 ? 153.333 131.768 158.120 1.00 161.95 ? 246 PRO   A N   1 
ATOM   1489 C  CA  . PRO   A 1 197 ? 154.480 131.265 158.908 1.00 158.19 ? 246 PRO   A CA  1 
ATOM   1490 C  C   . PRO   A 1 197 ? 155.283 132.407 159.522 1.00 155.44 ? 246 PRO   A C   1 
ATOM   1491 O  O   . PRO   A 1 197 ? 156.459 132.636 159.223 1.00 154.94 ? 246 PRO   A O   1 
ATOM   1492 C  CB  . PRO   A 1 197 ? 155.278 130.464 157.868 1.00 159.61 ? 246 PRO   A CB  1 
ATOM   1493 C  CG  . PRO   A 1 197 ? 154.518 130.560 156.556 1.00 159.14 ? 246 PRO   A CG  1 
ATOM   1494 C  CD  . PRO   A 1 197 ? 153.582 131.708 156.674 1.00 161.16 ? 246 PRO   A CD  1 
ATOM   1495 N  N   . LEU   A 1 198 ? 154.596 133.167 160.362 1.00 153.16 ? 247 LEU   A N   1 
ATOM   1496 C  CA  . LEU   A 1 198 ? 155.264 134.292 161.037 1.00 152.09 ? 247 LEU   A CA  1 
ATOM   1497 C  C   . LEU   A 1 198 ? 156.373 133.655 161.867 1.00 154.74 ? 247 LEU   A C   1 
ATOM   1498 O  O   . LEU   A 1 198 ? 156.156 132.533 162.314 1.00 159.07 ? 247 LEU   A O   1 
ATOM   1499 C  CB  . LEU   A 1 198 ? 154.238 134.993 161.928 1.00 154.04 ? 247 LEU   A CB  1 
ATOM   1500 C  CG  . LEU   A 1 198 ? 154.632 136.332 162.551 1.00 154.36 ? 247 LEU   A CG  1 
ATOM   1501 C  CD1 . LEU   A 1 198 ? 154.624 137.444 161.519 1.00 153.22 ? 247 LEU   A CD1 1 
ATOM   1502 C  CD2 . LEU   A 1 198 ? 153.714 136.689 163.706 1.00 157.85 ? 247 LEU   A CD2 1 
ATOM   1503 N  N   . PRO   A 1 199 ? 157.518 134.310 162.139 1.00 161.23 ? 248 PRO   A N   1 
ATOM   1504 C  CA  . PRO   A 1 199 ? 158.577 133.745 162.990 1.00 162.66 ? 248 PRO   A CA  1 
ATOM   1505 C  C   . PRO   A 1 199 ? 158.144 133.566 164.435 1.00 164.15 ? 248 PRO   A C   1 
ATOM   1506 O  O   . PRO   A 1 199 ? 158.581 132.613 165.086 1.00 159.72 ? 248 PRO   A O   1 
ATOM   1507 C  CB  . PRO   A 1 199 ? 159.736 134.745 162.817 1.00 161.49 ? 248 PRO   A CB  1 
ATOM   1508 C  CG  . PRO   A 1 199 ? 159.225 135.806 161.864 1.00 162.53 ? 248 PRO   A CG  1 
ATOM   1509 C  CD  . PRO   A 1 199 ? 157.754 135.744 161.941 1.00 160.61 ? 248 PRO   A CD  1 
ATOM   1510 N  N   . SER   A 1 200 ? 157.268 134.433 164.945 1.00 161.19 ? 249 SER   A N   1 
ATOM   1511 C  CA  . SER   A 1 200 ? 156.695 134.205 166.270 1.00 157.39 ? 249 SER   A CA  1 
ATOM   1512 C  C   . SER   A 1 200 ? 155.864 132.927 166.301 1.00 156.31 ? 249 SER   A C   1 
ATOM   1513 O  O   . SER   A 1 200 ? 155.957 132.139 167.251 1.00 158.56 ? 249 SER   A O   1 
ATOM   1514 C  CB  . SER   A 1 200 ? 155.845 135.404 166.688 1.00 156.01 ? 249 SER   A CB  1 
ATOM   1515 O  OG  . SER   A 1 200 ? 154.858 135.022 167.629 1.00 156.96 ? 249 SER   A OG  1 
ATOM   1516 N  N   . PHE   A 1 201 ? 155.050 132.702 165.265 1.00 146.28 ? 250 PHE   A N   1 
ATOM   1517 C  CA  . PHE   A 1 201 ? 154.248 131.486 165.194 1.00 146.30 ? 250 PHE   A CA  1 
ATOM   1518 C  C   . PHE   A 1 201 ? 155.122 130.240 165.162 1.00 152.12 ? 250 PHE   A C   1 
ATOM   1519 O  O   . PHE   A 1 201 ? 154.859 129.274 165.891 1.00 155.38 ? 250 PHE   A O   1 
ATOM   1520 C  CB  . PHE   A 1 201 ? 153.350 131.523 163.957 1.00 148.49 ? 250 PHE   A CB  1 
ATOM   1521 C  CG  . PHE   A 1 201 ? 152.035 132.214 164.177 1.00 149.51 ? 250 PHE   A CG  1 
ATOM   1522 C  CD1 . PHE   A 1 201 ? 151.977 133.434 164.826 1.00 148.90 ? 250 PHE   A CD1 1 
ATOM   1523 C  CD2 . PHE   A 1 201 ? 150.859 131.648 163.718 1.00 150.55 ? 250 PHE   A CD2 1 
ATOM   1524 C  CE1 . PHE   A 1 201 ? 150.769 134.072 165.023 1.00 148.94 ? 250 PHE   A CE1 1 
ATOM   1525 C  CE2 . PHE   A 1 201 ? 149.649 132.281 163.912 1.00 151.42 ? 250 PHE   A CE2 1 
ATOM   1526 C  CZ  . PHE   A 1 201 ? 149.604 133.494 164.565 1.00 151.82 ? 250 PHE   A CZ  1 
ATOM   1527 N  N   . ARG   A 1 202 ? 156.164 130.241 164.331 1.00 159.99 ? 251 ARG   A N   1 
ATOM   1528 C  CA  . ARG   A 1 202 ? 157.052 129.089 164.250 1.00 157.00 ? 251 ARG   A CA  1 
ATOM   1529 C  C   . ARG   A 1 202 ? 157.888 128.909 165.509 1.00 156.38 ? 251 ARG   A C   1 
ATOM   1530 O  O   . ARG   A 1 202 ? 158.171 127.768 165.892 1.00 157.52 ? 251 ARG   A O   1 
ATOM   1531 C  CB  . ARG   A 1 202 ? 157.950 129.192 163.011 1.00 156.81 ? 251 ARG   A CB  1 
ATOM   1532 C  CG  . ARG   A 1 202 ? 159.283 129.894 163.208 1.00 156.11 ? 251 ARG   A CG  1 
ATOM   1533 C  CD  . ARG   A 1 202 ? 160.036 129.991 161.889 1.00 158.44 ? 251 ARG   A CD  1 
ATOM   1534 N  NE  . ARG   A 1 202 ? 159.854 131.282 161.237 1.00 161.31 ? 251 ARG   A NE  1 
ATOM   1535 C  CZ  . ARG   A 1 202 ? 159.839 131.463 159.923 1.00 160.15 ? 251 ARG   A CZ  1 
ATOM   1536 N  NH1 . ARG   A 1 202 ? 159.990 130.451 159.085 1.00 158.97 ? 251 ARG   A NH1 1 
ATOM   1537 N  NH2 . ARG   A 1 202 ? 159.668 132.689 159.438 1.00 156.96 ? 251 ARG   A NH2 1 
ATOM   1538 N  N   . ARG   A 1 203 ? 158.263 130.002 166.179 1.00 151.75 ? 252 ARG   A N   1 
ATOM   1539 C  CA  . ARG   A 1 203 ? 158.925 129.894 167.473 1.00 153.16 ? 252 ARG   A CA  1 
ATOM   1540 C  C   . ARG   A 1 203 ? 158.021 129.205 168.483 1.00 154.59 ? 252 ARG   A C   1 
ATOM   1541 O  O   . ARG   A 1 203 ? 158.450 128.295 169.201 1.00 151.37 ? 252 ARG   A O   1 
ATOM   1542 C  CB  . ARG   A 1 203 ? 159.319 131.284 167.973 1.00 149.40 ? 252 ARG   A CB  1 
ATOM   1543 C  CG  . ARG   A 1 203 ? 160.731 131.715 167.628 1.00 152.82 ? 252 ARG   A CG  1 
ATOM   1544 C  CD  . ARG   A 1 203 ? 160.772 133.198 167.294 1.00 156.42 ? 252 ARG   A CD  1 
ATOM   1545 N  NE  . ARG   A 1 203 ? 160.055 133.997 168.281 1.00 157.84 ? 252 ARG   A NE  1 
ATOM   1546 C  CZ  . ARG   A 1 203 ? 160.126 135.318 168.372 1.00 157.21 ? 252 ARG   A CZ  1 
ATOM   1547 N  NH1 . ARG   A 1 203 ? 160.875 136.030 167.546 1.00 153.00 ? 252 ARG   A NH1 1 
ATOM   1548 N  NH2 . ARG   A 1 203 ? 159.424 135.942 169.315 1.00 157.52 ? 252 ARG   A NH2 1 
ATOM   1549 N  N   . ARG   A 1 204 ? 156.756 129.626 168.545 1.00 154.50 ? 253 ARG   A N   1 
ATOM   1550 C  CA  . ARG   A 1 204 ? 155.818 129.004 169.472 1.00 149.88 ? 253 ARG   A CA  1 
ATOM   1551 C  C   . ARG   A 1 204 ? 155.624 127.530 169.148 1.00 148.75 ? 253 ARG   A C   1 
ATOM   1552 O  O   . ARG   A 1 204 ? 155.591 126.687 170.052 1.00 155.38 ? 253 ARG   A O   1 
ATOM   1553 C  CB  . ARG   A 1 204 ? 154.481 129.739 169.438 1.00 148.48 ? 253 ARG   A CB  1 
ATOM   1554 C  CG  . ARG   A 1 204 ? 153.471 129.220 170.436 1.00 150.37 ? 253 ARG   A CG  1 
ATOM   1555 C  CD  . ARG   A 1 204 ? 152.059 129.491 169.962 1.00 154.33 ? 253 ARG   A CD  1 
ATOM   1556 N  NE  . ARG   A 1 204 ? 151.895 129.178 168.549 1.00 152.73 ? 253 ARG   A NE  1 
ATOM   1557 C  CZ  . ARG   A 1 204 ? 150.988 129.737 167.761 1.00 152.41 ? 253 ARG   A CZ  1 
ATOM   1558 N  NH1 . ARG   A 1 204 ? 150.149 130.653 168.215 1.00 150.14 ? 253 ARG   A NH1 1 
ATOM   1559 N  NH2 . ARG   A 1 204 ? 150.921 129.367 166.485 1.00 154.52 ? 253 ARG   A NH2 1 
ATOM   1560 N  N   . ASP   A 1 205 ? 155.497 127.198 167.861 1.00 155.41 ? 254 ASP   A N   1 
ATOM   1561 C  CA  . ASP   A 1 205 ? 155.300 125.805 167.472 1.00 158.41 ? 254 ASP   A CA  1 
ATOM   1562 C  C   . ASP   A 1 205 ? 156.505 124.949 167.847 1.00 157.25 ? 254 ASP   A C   1 
ATOM   1563 O  O   . ASP   A 1 205 ? 156.356 123.855 168.408 1.00 158.33 ? 254 ASP   A O   1 
ATOM   1564 C  CB  . ASP   A 1 205 ? 155.021 125.719 165.972 1.00 157.88 ? 254 ASP   A CB  1 
ATOM   1565 C  CG  . ASP   A 1 205 ? 153.678 126.314 165.595 1.00 159.42 ? 254 ASP   A CG  1 
ATOM   1566 O  OD1 . ASP   A 1 205 ? 152.773 126.340 166.456 1.00 157.31 ? 254 ASP   A OD1 1 
ATOM   1567 O  OD2 . ASP   A 1 205 ? 153.527 126.760 164.439 1.00 160.38 ? 254 ASP   A OD2 1 
ATOM   1568 N  N   . ARG   A 1 206 ? 157.714 125.436 167.552 1.00 150.24 ? 255 ARG   A N   1 
ATOM   1569 C  CA  . ARG   A 1 206 ? 158.919 124.689 167.894 1.00 150.77 ? 255 ARG   A CA  1 
ATOM   1570 C  C   . ARG   A 1 206 ? 159.050 124.527 169.401 1.00 149.98 ? 255 ARG   A C   1 
ATOM   1571 O  O   . ARG   A 1 206 ? 159.437 123.457 169.889 1.00 150.61 ? 255 ARG   A O   1 
ATOM   1572 C  CB  . ARG   A 1 206 ? 160.147 125.391 167.311 1.00 151.24 ? 255 ARG   A CB  1 
ATOM   1573 C  CG  . ARG   A 1 206 ? 161.476 124.685 167.555 1.00 147.75 ? 255 ARG   A CG  1 
ATOM   1574 C  CD  . ARG   A 1 206 ? 162.192 125.217 168.791 1.00 146.47 ? 255 ARG   A CD  1 
ATOM   1575 N  NE  . ARG   A 1 206 ? 161.892 126.620 169.052 1.00 150.31 ? 255 ARG   A NE  1 
ATOM   1576 C  CZ  . ARG   A 1 206 ? 162.435 127.639 168.400 1.00 153.42 ? 255 ARG   A CZ  1 
ATOM   1577 N  NH1 . ARG   A 1 206 ? 163.313 127.450 167.429 1.00 152.91 ? 255 ARG   A NH1 1 
ATOM   1578 N  NH2 . ARG   A 1 206 ? 162.089 128.879 168.733 1.00 151.27 ? 255 ARG   A NH2 1 
ATOM   1579 N  N   . ALA   A 1 207 ? 158.739 125.584 170.154 1.00 142.91 ? 256 ALA   A N   1 
ATOM   1580 C  CA  . ALA   A 1 207 ? 158.789 125.495 171.607 1.00 147.25 ? 256 ALA   A CA  1 
ATOM   1581 C  C   . ALA   A 1 207 ? 157.811 124.452 172.120 1.00 144.11 ? 256 ALA   A C   1 
ATOM   1582 O  O   . ALA   A 1 207 ? 158.143 123.670 173.016 1.00 148.98 ? 256 ALA   A O   1 
ATOM   1583 C  CB  . ALA   A 1 207 ? 158.495 126.860 172.227 1.00 145.87 ? 256 ALA   A CB  1 
ATOM   1584 N  N   . HIS   A 1 208 ? 156.601 124.420 171.560 1.00 133.64 ? 257 HIS   A N   1 
ATOM   1585 C  CA  . HIS   A 1 208 ? 155.622 123.436 172.003 1.00 133.69 ? 257 HIS   A CA  1 
ATOM   1586 C  C   . HIS   A 1 208 ? 156.091 122.018 171.708 1.00 138.60 ? 257 HIS   A C   1 
ATOM   1587 O  O   . HIS   A 1 208 ? 155.962 121.129 172.557 1.00 145.21 ? 257 HIS   A O   1 
ATOM   1588 C  CB  . HIS   A 1 208 ? 154.269 123.700 171.349 1.00 135.03 ? 257 HIS   A CB  1 
ATOM   1589 C  CG  . HIS   A 1 208 ? 153.279 122.601 171.559 1.00 132.04 ? 257 HIS   A CG  1 
ATOM   1590 N  ND1 . HIS   A 1 208 ? 152.701 121.908 170.518 1.00 137.25 ? 257 HIS   A ND1 1 
ATOM   1591 C  CD2 . HIS   A 1 208 ? 152.766 122.070 172.694 1.00 134.02 ? 257 HIS   A CD2 1 
ATOM   1592 C  CE1 . HIS   A 1 208 ? 151.874 121.000 171.001 1.00 140.52 ? 257 HIS   A CE1 1 
ATOM   1593 N  NE2 . HIS   A 1 208 ? 151.894 121.077 172.320 1.00 139.84 ? 257 HIS   A NE2 1 
ATOM   1594 N  N   . ARG   A 1 209 ? 156.646 121.784 170.513 1.00 147.34 ? 258 ARG   A N   1 
ATOM   1595 C  CA  . ARG   A 1 209 ? 157.132 120.440 170.199 1.00 149.18 ? 258 ARG   A CA  1 
ATOM   1596 C  C   . ARG   A 1 209 ? 158.274 120.027 171.121 1.00 152.82 ? 258 ARG   A C   1 
ATOM   1597 O  O   . ARG   A 1 209 ? 158.290 118.899 171.632 1.00 156.30 ? 258 ARG   A O   1 
ATOM   1598 C  CB  . ARG   A 1 209 ? 157.569 120.339 168.736 1.00 152.36 ? 258 ARG   A CB  1 
ATOM   1599 C  CG  . ARG   A 1 209 ? 156.600 120.933 167.735 1.00 152.05 ? 258 ARG   A CG  1 
ATOM   1600 C  CD  . ARG   A 1 209 ? 157.184 120.998 166.325 1.00 153.67 ? 258 ARG   A CD  1 
ATOM   1601 N  NE  . ARG   A 1 209 ? 158.514 121.597 166.276 1.00 157.65 ? 258 ARG   A NE  1 
ATOM   1602 C  CZ  . ARG   A 1 209 ? 159.646 120.910 166.187 1.00 153.59 ? 258 ARG   A CZ  1 
ATOM   1603 N  NH1 . ARG   A 1 209 ? 159.650 119.588 166.142 1.00 151.66 ? 258 ARG   A NH1 1 
ATOM   1604 N  NH2 . ARG   A 1 209 ? 160.801 121.566 166.143 1.00 151.70 ? 258 ARG   A NH2 1 
ATOM   1605 N  N   . GLU   A 1 210 ? 159.235 120.924 171.356 1.00 148.01 ? 259 GLU   A N   1 
ATOM   1606 C  CA  . GLU   A 1 210 ? 160.360 120.578 172.221 1.00 146.32 ? 259 GLU   A CA  1 
ATOM   1607 C  C   . GLU   A 1 210 ? 159.904 120.327 173.654 1.00 148.65 ? 259 GLU   A C   1 
ATOM   1608 O  O   . GLU   A 1 210 ? 160.371 119.382 174.308 1.00 151.52 ? 259 GLU   A O   1 
ATOM   1609 C  CB  . GLU   A 1 210 ? 161.416 121.682 172.174 1.00 149.34 ? 259 GLU   A CB  1 
ATOM   1610 C  CG  . GLU   A 1 210 ? 162.246 121.681 170.900 1.00 154.51 ? 259 GLU   A CG  1 
ATOM   1611 C  CD  . GLU   A 1 210 ? 163.386 122.680 170.939 1.00 154.53 ? 259 GLU   A CD  1 
ATOM   1612 O  OE1 . GLU   A 1 210 ? 163.633 123.263 172.015 1.00 153.47 ? 259 GLU   A OE1 1 
ATOM   1613 O  OE2 . GLU   A 1 210 ? 164.046 122.871 169.896 1.00 153.20 ? 259 GLU   A OE2 1 
ATOM   1614 N  N   . ILE   A 1 211 ? 158.990 121.162 174.157 1.00 132.90 ? 260 ILE   A N   1 
ATOM   1615 C  CA  . ILE   A 1 211 ? 158.489 120.997 175.517 1.00 132.65 ? 260 ILE   A CA  1 
ATOM   1616 C  C   . ILE   A 1 211 ? 157.728 119.688 175.649 1.00 129.23 ? 260 ILE   A C   1 
ATOM   1617 O  O   . ILE   A 1 211 ? 157.890 118.958 176.632 1.00 132.94 ? 260 ILE   A O   1 
ATOM   1618 C  CB  . ILE   A 1 211 ? 157.623 122.204 175.921 1.00 130.49 ? 260 ILE   A CB  1 
ATOM   1619 C  CG1 . ILE   A 1 211 ? 158.506 123.421 176.176 1.00 133.52 ? 260 ILE   A CG1 1 
ATOM   1620 C  CG2 . ILE   A 1 211 ? 156.822 121.892 177.167 1.00 126.92 ? 260 ILE   A CG2 1 
ATOM   1621 C  CD1 . ILE   A 1 211 ? 159.591 123.167 177.183 1.00 134.58 ? 260 ILE   A CD1 1 
ATOM   1622 N  N   . LYS   A 1 212 ? 156.895 119.359 174.661 1.00 125.62 ? 261 LYS   A N   1 
ATOM   1623 C  CA  . LYS   A 1 212 ? 156.179 118.094 174.730 1.00 130.20 ? 261 LYS   A CA  1 
ATOM   1624 C  C   . LYS   A 1 212 ? 157.125 116.906 174.631 1.00 137.39 ? 261 LYS   A C   1 
ATOM   1625 O  O   . LYS   A 1 212 ? 156.878 115.877 175.261 1.00 137.67 ? 261 LYS   A O   1 
ATOM   1626 C  CB  . LYS   A 1 212 ? 155.108 118.024 173.644 1.00 134.22 ? 261 LYS   A CB  1 
ATOM   1627 C  CG  . LYS   A 1 212 ? 153.812 117.401 174.130 1.00 134.59 ? 261 LYS   A CG  1 
ATOM   1628 C  CD  . LYS   A 1 212 ? 152.603 118.201 173.690 1.00 135.73 ? 261 LYS   A CD  1 
ATOM   1629 C  CE  . LYS   A 1 212 ? 151.318 117.566 174.192 1.00 138.34 ? 261 LYS   A CE  1 
ATOM   1630 N  NZ  . LYS   A 1 212 ? 150.191 117.748 173.236 1.00 138.84 ? 261 LYS   A NZ  1 
ATOM   1631 N  N   . ASP   A 1 213 ? 158.219 117.027 173.877 1.00 160.04 ? 262 ASP   A N   1 
ATOM   1632 C  CA  . ASP   A 1 213 ? 159.172 115.922 173.794 1.00 160.71 ? 262 ASP   A CA  1 
ATOM   1633 C  C   . ASP   A 1 213 ? 159.880 115.694 175.127 1.00 159.51 ? 262 ASP   A C   1 
ATOM   1634 O  O   . ASP   A 1 213 ? 159.957 114.556 175.619 1.00 159.66 ? 262 ASP   A O   1 
ATOM   1635 C  CB  . ASP   A 1 213 ? 160.185 116.186 172.681 1.00 160.01 ? 262 ASP   A CB  1 
ATOM   1636 C  CG  . ASP   A 1 213 ? 159.837 115.465 171.393 1.00 162.12 ? 262 ASP   A CG  1 
ATOM   1637 O  OD1 . ASP   A 1 213 ? 159.864 114.216 171.384 1.00 162.40 ? 262 ASP   A OD1 1 
ATOM   1638 O  OD2 . ASP   A 1 213 ? 159.534 116.145 170.391 1.00 163.26 ? 262 ASP   A OD2 1 
ATOM   1639 N  N   . ILE   A 1 214 ? 160.408 116.764 175.731 1.00 142.18 ? 263 ILE   A N   1 
ATOM   1640 C  CA  . ILE   A 1 214 ? 161.081 116.603 177.020 1.00 142.54 ? 263 ILE   A CA  1 
ATOM   1641 C  C   . ILE   A 1 214 ? 160.086 116.130 178.072 1.00 141.05 ? 263 ILE   A C   1 
ATOM   1642 O  O   . ILE   A 1 214 ? 160.423 115.334 178.961 1.00 139.70 ? 263 ILE   A O   1 
ATOM   1643 C  CB  . ILE   A 1 214 ? 161.792 117.904 177.444 1.00 140.82 ? 263 ILE   A CB  1 
ATOM   1644 C  CG1 . ILE   A 1 214 ? 162.310 117.790 178.878 1.00 140.95 ? 263 ILE   A CG1 1 
ATOM   1645 C  CG2 . ILE   A 1 214 ? 160.867 119.086 177.366 1.00 139.18 ? 263 ILE   A CG2 1 
ATOM   1646 C  CD1 . ILE   A 1 214 ? 162.966 119.053 179.389 1.00 141.03 ? 263 ILE   A CD1 1 
ATOM   1647 N  N   . PHE   A 1 215 ? 158.836 116.585 177.972 1.00 134.99 ? 264 PHE   A N   1 
ATOM   1648 C  CA  . PHE   A 1 215 ? 157.825 116.160 178.925 1.00 135.03 ? 264 PHE   A CA  1 
ATOM   1649 C  C   . PHE   A 1 215 ? 157.455 114.698 178.726 1.00 136.01 ? 264 PHE   A C   1 
ATOM   1650 O  O   . PHE   A 1 215 ? 157.164 114.001 179.700 1.00 141.14 ? 264 PHE   A O   1 
ATOM   1651 C  CB  . PHE   A 1 215 ? 156.593 117.051 178.802 1.00 134.71 ? 264 PHE   A CB  1 
ATOM   1652 C  CG  . PHE   A 1 215 ? 155.928 117.327 180.107 1.00 133.38 ? 264 PHE   A CG  1 
ATOM   1653 C  CD1 . PHE   A 1 215 ? 156.426 118.309 180.943 1.00 134.76 ? 264 PHE   A CD1 1 
ATOM   1654 C  CD2 . PHE   A 1 215 ? 154.830 116.600 180.515 1.00 134.90 ? 264 PHE   A CD2 1 
ATOM   1655 C  CE1 . PHE   A 1 215 ? 155.834 118.571 182.151 1.00 138.72 ? 264 PHE   A CE1 1 
ATOM   1656 C  CE2 . PHE   A 1 215 ? 154.233 116.857 181.726 1.00 137.50 ? 264 PHE   A CE2 1 
ATOM   1657 C  CZ  . PHE   A 1 215 ? 154.740 117.844 182.545 1.00 137.39 ? 264 PHE   A CZ  1 
ATOM   1658 N  N   . TYR   A 1 216 ? 157.460 114.217 177.480 1.00 144.36 ? 265 TYR   A N   1 
ATOM   1659 C  CA  . TYR   A 1 216 ? 157.254 112.796 177.228 1.00 147.18 ? 265 TYR   A CA  1 
ATOM   1660 C  C   . TYR   A 1 216 ? 158.364 111.973 177.862 1.00 146.96 ? 265 TYR   A C   1 
ATOM   1661 O  O   . TYR   A 1 216 ? 158.109 110.934 178.481 1.00 146.18 ? 265 TYR   A O   1 
ATOM   1662 C  CB  . TYR   A 1 216 ? 157.196 112.527 175.723 1.00 145.76 ? 265 TYR   A CB  1 
ATOM   1663 C  CG  . TYR   A 1 216 ? 155.932 112.992 175.043 1.00 147.56 ? 265 TYR   A CG  1 
ATOM   1664 C  CD1 . TYR   A 1 216 ? 154.735 113.082 175.738 1.00 148.28 ? 265 TYR   A CD1 1 
ATOM   1665 C  CD2 . TYR   A 1 216 ? 155.937 113.339 173.699 1.00 148.18 ? 265 TYR   A CD2 1 
ATOM   1666 C  CE1 . TYR   A 1 216 ? 153.580 113.508 175.114 1.00 147.09 ? 265 TYR   A CE1 1 
ATOM   1667 C  CE2 . TYR   A 1 216 ? 154.789 113.765 173.067 1.00 150.27 ? 265 TYR   A CE2 1 
ATOM   1668 C  CZ  . TYR   A 1 216 ? 153.614 113.847 173.777 1.00 149.37 ? 265 TYR   A CZ  1 
ATOM   1669 O  OH  . TYR   A 1 216 ? 152.471 114.272 173.145 1.00 148.36 ? 265 TYR   A OH  1 
ATOM   1670 N  N   . LYS   A 1 217 ? 159.611 112.425 177.708 1.00 149.16 ? 266 LYS   A N   1 
ATOM   1671 C  CA  . LYS   A 1 217 ? 160.723 111.712 178.332 1.00 148.88 ? 266 LYS   A CA  1 
ATOM   1672 C  C   . LYS   A 1 217 ? 160.571 111.679 179.849 1.00 150.12 ? 266 LYS   A C   1 
ATOM   1673 O  O   . LYS   A 1 217 ? 160.760 110.630 180.482 1.00 151.57 ? 266 LYS   A O   1 
ATOM   1674 C  CB  . LYS   A 1 217 ? 162.053 112.354 177.941 1.00 147.66 ? 266 LYS   A CB  1 
ATOM   1675 C  CG  . LYS   A 1 217 ? 162.337 112.350 176.449 1.00 149.35 ? 266 LYS   A CG  1 
ATOM   1676 C  CD  . LYS   A 1 217 ? 163.756 112.818 176.163 1.00 151.65 ? 266 LYS   A CD  1 
ATOM   1677 C  CE  . LYS   A 1 217 ? 163.826 114.331 176.035 1.00 150.72 ? 266 LYS   A CE  1 
ATOM   1678 N  NZ  . LYS   A 1 217 ? 165.231 114.822 176.008 1.00 147.84 ? 266 LYS   A NZ  1 
ATOM   1679 N  N   . ALA   A 1 218 ? 160.212 112.817 180.448 1.00 152.97 ? 267 ALA   A N   1 
ATOM   1680 C  CA  . ALA   A 1 218 ? 160.034 112.871 181.896 1.00 154.05 ? 267 ALA   A CA  1 
ATOM   1681 C  C   . ALA   A 1 218 ? 158.880 111.985 182.351 1.00 154.56 ? 267 ALA   A C   1 
ATOM   1682 O  O   . ALA   A 1 218 ? 158.974 111.315 183.387 1.00 156.04 ? 267 ALA   A O   1 
ATOM   1683 C  CB  . ALA   A 1 218 ? 159.812 114.316 182.340 1.00 149.59 ? 267 ALA   A CB  1 
ATOM   1684 N  N   . ILE   A 1 219 ? 157.779 111.975 181.596 1.00 144.53 ? 268 ILE   A N   1 
ATOM   1685 C  CA  . ILE   A 1 219 ? 156.631 111.146 181.948 1.00 141.00 ? 268 ILE   A CA  1 
ATOM   1686 C  C   . ILE   A 1 219 ? 157.000 109.673 181.884 1.00 147.36 ? 268 ILE   A C   1 
ATOM   1687 O  O   . ILE   A 1 219 ? 156.627 108.887 182.762 1.00 151.37 ? 268 ILE   A O   1 
ATOM   1688 C  CB  . ILE   A 1 219 ? 155.436 111.470 181.032 1.00 140.81 ? 268 ILE   A CB  1 
ATOM   1689 C  CG1 . ILE   A 1 219 ? 154.753 112.763 181.475 1.00 144.37 ? 268 ILE   A CG1 1 
ATOM   1690 C  CG2 . ILE   A 1 219 ? 154.435 110.327 181.023 1.00 142.62 ? 268 ILE   A CG2 1 
ATOM   1691 C  CD1 . ILE   A 1 219 ? 153.729 113.269 180.488 1.00 145.58 ? 268 ILE   A CD1 1 
ATOM   1692 N  N   . GLN   A 1 220 ? 157.732 109.272 180.842 1.00 157.06 ? 269 GLN   A N   1 
ATOM   1693 C  CA  . GLN   A 1 220 ? 158.166 107.883 180.744 1.00 154.85 ? 269 GLN   A CA  1 
ATOM   1694 C  C   . GLN   A 1 220 ? 159.074 107.511 181.908 1.00 153.73 ? 269 GLN   A C   1 
ATOM   1695 O  O   . GLN   A 1 220 ? 158.939 106.426 182.487 1.00 152.27 ? 269 GLN   A O   1 
ATOM   1696 C  CB  . GLN   A 1 220 ? 158.874 107.641 179.411 1.00 156.01 ? 269 GLN   A CB  1 
ATOM   1697 C  CG  . GLN   A 1 220 ? 157.976 107.783 178.193 1.00 157.77 ? 269 GLN   A CG  1 
ATOM   1698 C  CD  . GLN   A 1 220 ? 156.890 106.727 178.140 1.00 159.10 ? 269 GLN   A CD  1 
ATOM   1699 O  OE1 . GLN   A 1 220 ? 157.099 105.584 178.545 1.00 161.33 ? 269 GLN   A OE1 1 
ATOM   1700 N  NE2 . GLN   A 1 220 ? 155.721 107.106 177.636 1.00 155.58 ? 269 GLN   A NE2 1 
ATOM   1701 N  N   . LYS   A 1 221 ? 160.001 108.402 182.271 1.00 158.21 ? 270 LYS   A N   1 
ATOM   1702 C  CA  . LYS   A 1 221 ? 160.885 108.114 183.396 1.00 159.24 ? 270 LYS   A CA  1 
ATOM   1703 C  C   . LYS   A 1 221 ? 160.099 107.963 184.693 1.00 161.36 ? 270 LYS   A C   1 
ATOM   1704 O  O   . LYS   A 1 221 ? 160.341 107.032 185.469 1.00 164.98 ? 270 LYS   A O   1 
ATOM   1705 C  CB  . LYS   A 1 221 ? 161.939 109.211 183.533 1.00 158.55 ? 270 LYS   A CB  1 
ATOM   1706 C  CG  . LYS   A 1 221 ? 163.117 108.823 184.411 1.00 159.68 ? 270 LYS   A CG  1 
ATOM   1707 C  CD  . LYS   A 1 221 ? 164.224 109.859 184.343 1.00 160.50 ? 270 LYS   A CD  1 
ATOM   1708 C  CE  . LYS   A 1 221 ? 163.864 111.101 185.141 1.00 161.06 ? 270 LYS   A CE  1 
ATOM   1709 N  NZ  . LYS   A 1 221 ? 163.527 110.771 186.554 1.00 158.73 ? 270 LYS   A NZ  1 
ATOM   1710 N  N   . ARG   A 1 222 ? 159.147 108.866 184.942 1.00 162.33 ? 271 ARG   A N   1 
ATOM   1711 C  CA  . ARG   A 1 222 ? 158.351 108.784 186.164 1.00 160.11 ? 271 ARG   A CA  1 
ATOM   1712 C  C   . ARG   A 1 222 ? 157.501 107.520 186.185 1.00 161.00 ? 271 ARG   A C   1 
ATOM   1713 O  O   . ARG   A 1 222 ? 157.372 106.867 187.227 1.00 161.68 ? 271 ARG   A O   1 
ATOM   1714 C  CB  . ARG   A 1 222 ? 157.475 110.030 186.302 1.00 160.15 ? 271 ARG   A CB  1 
ATOM   1715 C  CG  . ARG   A 1 222 ? 156.230 109.834 187.152 1.00 158.61 ? 271 ARG   A CG  1 
ATOM   1716 C  CD  . ARG   A 1 222 ? 156.574 109.743 188.632 1.00 159.26 ? 271 ARG   A CD  1 
ATOM   1717 N  NE  . ARG   A 1 222 ? 157.226 110.949 189.127 1.00 163.67 ? 271 ARG   A NE  1 
ATOM   1718 C  CZ  . ARG   A 1 222 ? 156.609 112.102 189.346 1.00 165.19 ? 271 ARG   A CZ  1 
ATOM   1719 N  NH1 . ARG   A 1 222 ? 155.312 112.246 189.126 1.00 166.20 ? 271 ARG   A NH1 1 
ATOM   1720 N  NH2 . ARG   A 1 222 ? 157.309 113.137 189.801 1.00 160.75 ? 271 ARG   A NH2 1 
ATOM   1721 N  N   . ARG   A 1 223 ? 156.912 107.160 185.042 1.00 165.63 ? 272 ARG   A N   1 
ATOM   1722 C  CA  . ARG   A 1 223 ? 156.107 105.946 184.968 1.00 165.65 ? 272 ARG   A CA  1 
ATOM   1723 C  C   . ARG   A 1 223 ? 156.955 104.709 185.233 1.00 168.78 ? 272 ARG   A C   1 
ATOM   1724 O  O   . ARG   A 1 223 ? 156.518 103.783 185.927 1.00 168.50 ? 272 ARG   A O   1 
ATOM   1725 C  CB  . ARG   A 1 223 ? 155.428 105.856 183.601 1.00 165.35 ? 272 ARG   A CB  1 
ATOM   1726 C  CG  . ARG   A 1 223 ? 154.685 104.557 183.351 1.00 166.39 ? 272 ARG   A CG  1 
ATOM   1727 C  CD  . ARG   A 1 223 ? 153.386 104.811 182.603 1.00 165.44 ? 272 ARG   A CD  1 
ATOM   1728 N  NE  . ARG   A 1 223 ? 152.457 105.623 183.380 1.00 165.81 ? 272 ARG   A NE  1 
ATOM   1729 C  CZ  . ARG   A 1 223 ? 151.741 105.174 184.402 1.00 167.78 ? 272 ARG   A CZ  1 
ATOM   1730 N  NH1 . ARG   A 1 223 ? 151.810 103.913 184.794 1.00 167.47 ? 272 ARG   A NH1 1 
ATOM   1731 N  NH2 . ARG   A 1 223 ? 150.932 106.012 185.044 1.00 167.72 ? 272 ARG   A NH2 1 
ATOM   1732 N  N   . GLN   A 1 224 ? 158.173 104.676 184.692 1.00 175.42 ? 273 GLN   A N   1 
ATOM   1733 C  CA  . GLN   A 1 224 ? 159.077 103.562 184.939 1.00 173.98 ? 273 GLN   A CA  1 
ATOM   1734 C  C   . GLN   A 1 224 ? 159.692 103.593 186.332 1.00 174.64 ? 273 GLN   A C   1 
ATOM   1735 O  O   . GLN   A 1 224 ? 160.276 102.588 186.752 1.00 173.36 ? 273 GLN   A O   1 
ATOM   1736 C  CB  . GLN   A 1 224 ? 160.190 103.548 183.889 1.00 172.94 ? 273 GLN   A CB  1 
ATOM   1737 C  CG  . GLN   A 1 224 ? 159.727 103.137 182.501 1.00 175.03 ? 273 GLN   A CG  1 
ATOM   1738 C  CD  . GLN   A 1 224 ? 160.857 103.118 181.492 1.00 175.83 ? 273 GLN   A CD  1 
ATOM   1739 O  OE1 . GLN   A 1 224 ? 161.878 102.461 181.698 1.00 175.14 ? 273 GLN   A OE1 1 
ATOM   1740 N  NE2 . GLN   A 1 224 ? 160.681 103.842 180.393 1.00 174.84 ? 273 GLN   A NE2 1 
ATOM   1741 N  N   . SER   A 1 225 ? 159.582 104.711 187.047 1.00 189.61 ? 274 SER   A N   1 
ATOM   1742 C  CA  . SER   A 1 225 ? 160.155 104.805 188.385 1.00 189.63 ? 274 SER   A CA  1 
ATOM   1743 C  C   . SER   A 1 225 ? 159.458 103.845 189.340 1.00 190.19 ? 274 SER   A C   1 
ATOM   1744 O  O   . SER   A 1 225 ? 158.226 103.792 189.403 1.00 188.65 ? 274 SER   A O   1 
ATOM   1745 C  CB  . SER   A 1 225 ? 160.046 106.238 188.905 1.00 188.17 ? 274 SER   A CB  1 
ATOM   1746 O  OG  . SER   A 1 225 ? 160.086 106.270 190.321 1.00 187.81 ? 274 SER   A OG  1 
ATOM   1747 N  N   . GLN   A 1 226 ? 160.257 103.081 190.088 1.00 207.20 ? 275 GLN   A N   1 
ATOM   1748 C  CA  . GLN   A 1 226 ? 159.705 102.131 191.047 1.00 206.73 ? 275 GLN   A CA  1 
ATOM   1749 C  C   . GLN   A 1 226 ? 159.165 102.830 192.288 1.00 207.00 ? 275 GLN   A C   1 
ATOM   1750 O  O   . GLN   A 1 226 ? 158.093 102.471 192.789 1.00 206.88 ? 275 GLN   A O   1 
ATOM   1751 C  CB  . GLN   A 1 226 ? 160.766 101.100 191.437 1.00 205.48 ? 275 GLN   A CB  1 
ATOM   1752 C  CG  . GLN   A 1 226 ? 161.103 100.095 190.344 1.00 206.28 ? 275 GLN   A CG  1 
ATOM   1753 C  CD  . GLN   A 1 226 ? 161.960 100.688 189.243 1.00 207.13 ? 275 GLN   A CD  1 
ATOM   1754 O  OE1 . GLN   A 1 226 ? 162.741 101.610 189.477 1.00 207.18 ? 275 GLN   A OE1 1 
ATOM   1755 N  NE2 . GLN   A 1 226 ? 161.817 100.161 188.032 1.00 205.83 ? 275 GLN   A NE2 1 
ATOM   1756 N  N   . GLU   A 1 227 ? 159.890 103.823 192.797 1.00 206.13 ? 276 GLU   A N   1 
ATOM   1757 C  CA  . GLU   A 1 227 ? 159.476 104.511 194.012 1.00 205.88 ? 276 GLU   A CA  1 
ATOM   1758 C  C   . GLU   A 1 227 ? 158.213 105.326 193.764 1.00 206.37 ? 276 GLU   A C   1 
ATOM   1759 O  O   . GLU   A 1 227 ? 158.033 105.916 192.695 1.00 205.65 ? 276 GLU   A O   1 
ATOM   1760 C  CB  . GLU   A 1 227 ? 160.601 105.417 194.516 1.00 205.70 ? 276 GLU   A CB  1 
ATOM   1761 C  CG  . GLU   A 1 227 ? 160.297 106.135 195.824 1.00 206.49 ? 276 GLU   A CG  1 
ATOM   1762 C  CD  . GLU   A 1 227 ? 160.445 105.238 197.039 1.00 206.50 ? 276 GLU   A CD  1 
ATOM   1763 O  OE1 . GLU   A 1 227 ? 160.831 104.061 196.873 1.00 206.14 ? 276 GLU   A OE1 1 
ATOM   1764 O  OE2 . GLU   A 1 227 ? 160.176 105.710 198.163 1.00 207.48 ? 276 GLU   A OE2 1 
ATOM   1765 N  N   . LYS   A 1 228 ? 157.333 105.354 194.761 1.00 203.68 ? 277 LYS   A N   1 
ATOM   1766 C  CA  . LYS   A 1 228 ? 156.062 106.060 194.672 1.00 204.04 ? 277 LYS   A CA  1 
ATOM   1767 C  C   . LYS   A 1 228 ? 156.191 107.416 195.355 1.00 203.82 ? 277 LYS   A C   1 
ATOM   1768 O  O   . LYS   A 1 228 ? 156.543 107.490 196.537 1.00 202.23 ? 277 LYS   A O   1 
ATOM   1769 C  CB  . LYS   A 1 228 ? 154.938 105.242 195.310 1.00 203.36 ? 277 LYS   A CB  1 
ATOM   1770 C  CG  . LYS   A 1 228 ? 154.880 103.786 194.864 1.00 201.86 ? 277 LYS   A CG  1 
ATOM   1771 C  CD  . LYS   A 1 228 ? 154.980 103.653 193.351 1.00 203.03 ? 277 LYS   A CD  1 
ATOM   1772 C  CE  . LYS   A 1 228 ? 153.700 104.113 192.669 1.00 202.95 ? 277 LYS   A CE  1 
ATOM   1773 N  NZ  . LYS   A 1 228 ? 153.856 104.188 191.190 1.00 203.59 ? 277 LYS   A NZ  1 
ATOM   1774 N  N   . ILE   A 1 229 ? 155.905 108.481 194.610 1.00 188.23 ? 278 ILE   A N   1 
ATOM   1775 C  CA  . ILE   A 1 229 ? 155.958 109.845 195.120 1.00 186.89 ? 278 ILE   A CA  1 
ATOM   1776 C  C   . ILE   A 1 229 ? 154.677 110.560 194.717 1.00 184.39 ? 278 ILE   A C   1 
ATOM   1777 O  O   . ILE   A 1 229 ? 154.253 110.487 193.559 1.00 183.24 ? 278 ILE   A O   1 
ATOM   1778 C  CB  . ILE   A 1 229 ? 157.194 110.604 194.596 1.00 186.92 ? 278 ILE   A CB  1 
ATOM   1779 C  CG1 . ILE   A 1 229 ? 157.506 110.189 193.156 1.00 188.05 ? 278 ILE   A CG1 1 
ATOM   1780 C  CG2 . ILE   A 1 229 ? 158.393 110.354 195.496 1.00 184.78 ? 278 ILE   A CG2 1 
ATOM   1781 C  CD1 . ILE   A 1 229 ? 158.390 111.168 192.416 1.00 186.02 ? 278 ILE   A CD1 1 
ATOM   1782 N  N   . ASP   A 1 230 ? 154.063 111.252 195.673 1.00 170.14 ? 279 ASP   A N   1 
ATOM   1783 C  CA  . ASP   A 1 230 ? 152.808 111.955 195.437 1.00 170.73 ? 279 ASP   A CA  1 
ATOM   1784 C  C   . ASP   A 1 230 ? 153.100 113.336 194.865 1.00 170.18 ? 279 ASP   A C   1 
ATOM   1785 O  O   . ASP   A 1 230 ? 153.827 114.127 195.475 1.00 169.14 ? 279 ASP   A O   1 
ATOM   1786 C  CB  . ASP   A 1 230 ? 151.997 112.065 196.727 1.00 170.39 ? 279 ASP   A CB  1 
ATOM   1787 C  CG  . ASP   A 1 230 ? 152.863 112.346 197.937 1.00 171.40 ? 279 ASP   A CG  1 
ATOM   1788 O  OD1 . ASP   A 1 230 ? 154.102 112.388 197.786 1.00 170.91 ? 279 ASP   A OD1 1 
ATOM   1789 O  OD2 . ASP   A 1 230 ? 152.306 112.524 199.040 1.00 171.98 ? 279 ASP   A OD2 1 
ATOM   1790 N  N   . ASP   A 1 231 ? 152.533 113.621 193.696 1.00 160.65 ? 280 ASP   A N   1 
ATOM   1791 C  CA  . ASP   A 1 231 ? 152.729 114.892 193.017 1.00 157.76 ? 280 ASP   A CA  1 
ATOM   1792 C  C   . ASP   A 1 231 ? 151.548 115.124 192.085 1.00 155.21 ? 280 ASP   A C   1 
ATOM   1793 O  O   . ASP   A 1 231 ? 150.673 114.267 191.936 1.00 157.18 ? 280 ASP   A O   1 
ATOM   1794 C  CB  . ASP   A 1 231 ? 154.054 114.910 192.249 1.00 156.89 ? 280 ASP   A CB  1 
ATOM   1795 C  CG  . ASP   A 1 231 ? 155.147 115.646 192.991 1.00 158.97 ? 280 ASP   A CG  1 
ATOM   1796 O  OD1 . ASP   A 1 231 ? 154.829 116.360 193.965 1.00 157.60 ? 280 ASP   A OD1 1 
ATOM   1797 O  OD2 . ASP   A 1 231 ? 156.325 115.510 192.601 1.00 161.41 ? 280 ASP   A OD2 1 
ATOM   1798 N  N   . ILE   A 1 232 ? 151.527 116.299 191.452 1.00 131.35 ? 281 ILE   A N   1 
ATOM   1799 C  CA  . ILE   A 1 232 ? 150.494 116.580 190.460 1.00 132.49 ? 281 ILE   A CA  1 
ATOM   1800 C  C   . ILE   A 1 232 ? 150.613 115.617 189.287 1.00 136.51 ? 281 ILE   A C   1 
ATOM   1801 O  O   . ILE   A 1 232 ? 149.610 115.082 188.799 1.00 137.60 ? 281 ILE   A O   1 
ATOM   1802 C  CB  . ILE   A 1 232 ? 150.575 118.046 189.999 1.00 130.16 ? 281 ILE   A CB  1 
ATOM   1803 C  CG1 . ILE   A 1 232 ? 150.306 118.989 191.171 1.00 133.11 ? 281 ILE   A CG1 1 
ATOM   1804 C  CG2 . ILE   A 1 232 ? 149.586 118.306 188.878 1.00 127.07 ? 281 ILE   A CG2 1 
ATOM   1805 C  CD1 . ILE   A 1 232 ? 149.080 118.628 191.971 1.00 134.82 ? 281 ILE   A CD1 1 
ATOM   1806 N  N   . LEU   A 1 233 ? 151.841 115.378 188.819 1.00 141.28 ? 282 LEU   A N   1 
ATOM   1807 C  CA  . LEU   A 1 233 ? 152.045 114.460 187.704 1.00 138.54 ? 282 LEU   A CA  1 
ATOM   1808 C  C   . LEU   A 1 233 ? 151.607 113.046 188.065 1.00 141.41 ? 282 LEU   A C   1 
ATOM   1809 O  O   . LEU   A 1 233 ? 150.927 112.377 187.277 1.00 145.86 ? 282 LEU   A O   1 
ATOM   1810 C  CB  . LEU   A 1 233 ? 153.514 114.475 187.279 1.00 136.59 ? 282 LEU   A CB  1 
ATOM   1811 C  CG  . LEU   A 1 233 ? 153.849 114.263 185.801 1.00 137.58 ? 282 LEU   A CG  1 
ATOM   1812 C  CD1 . LEU   A 1 233 ? 155.309 114.589 185.543 1.00 139.92 ? 282 LEU   A CD1 1 
ATOM   1813 C  CD2 . LEU   A 1 233 ? 153.536 112.849 185.346 1.00 136.61 ? 282 LEU   A CD2 1 
ATOM   1814 N  N   . GLN   A 1 234 ? 151.988 112.574 189.254 1.00 151.90 ? 283 GLN   A N   1 
ATOM   1815 C  CA  . GLN   A 1 234 ? 151.608 111.228 189.667 1.00 153.57 ? 283 GLN   A CA  1 
ATOM   1816 C  C   . GLN   A 1 234 ? 150.099 111.109 189.833 1.00 152.74 ? 283 GLN   A C   1 
ATOM   1817 O  O   . GLN   A 1 234 ? 149.504 110.093 189.455 1.00 152.50 ? 283 GLN   A O   1 
ATOM   1818 C  CB  . GLN   A 1 234 ? 152.324 110.852 190.963 1.00 152.62 ? 283 GLN   A CB  1 
ATOM   1819 C  CG  . GLN   A 1 234 ? 152.124 109.404 191.382 1.00 154.51 ? 283 GLN   A CG  1 
ATOM   1820 C  CD  . GLN   A 1 234 ? 152.869 108.430 190.489 1.00 156.12 ? 283 GLN   A CD  1 
ATOM   1821 O  OE1 . GLN   A 1 234 ? 154.028 108.102 190.740 1.00 156.69 ? 283 GLN   A OE1 1 
ATOM   1822 N  NE2 . GLN   A 1 234 ? 152.203 107.958 189.441 1.00 156.31 ? 283 GLN   A NE2 1 
ATOM   1823 N  N   . THR   A 1 235 ? 149.464 112.135 190.404 1.00 146.66 ? 284 THR   A N   1 
ATOM   1824 C  CA  . THR   A 1 235 ? 148.014 112.117 190.553 1.00 148.05 ? 284 THR   A CA  1 
ATOM   1825 C  C   . THR   A 1 235 ? 147.326 112.083 189.195 1.00 147.78 ? 284 THR   A C   1 
ATOM   1826 O  O   . THR   A 1 235 ? 146.358 111.339 189.000 1.00 150.03 ? 284 THR   A O   1 
ATOM   1827 C  CB  . THR   A 1 235 ? 147.552 113.329 191.361 1.00 150.11 ? 284 THR   A CB  1 
ATOM   1828 O  OG1 . THR   A 1 235 ? 147.904 113.148 192.738 1.00 151.38 ? 284 THR   A OG1 1 
ATOM   1829 C  CG2 . THR   A 1 235 ? 146.047 113.505 191.252 1.00 148.75 ? 284 THR   A CG2 1 
ATOM   1830 N  N   . LEU   A 1 236 ? 147.818 112.875 188.240 1.00 140.27 ? 285 LEU   A N   1 
ATOM   1831 C  CA  . LEU   A 1 236 ? 147.239 112.862 186.901 1.00 140.57 ? 285 LEU   A CA  1 
ATOM   1832 C  C   . LEU   A 1 236 ? 147.411 111.503 186.239 1.00 144.13 ? 285 LEU   A C   1 
ATOM   1833 O  O   . LEU   A 1 236 ? 146.490 111.004 185.581 1.00 146.63 ? 285 LEU   A O   1 
ATOM   1834 C  CB  . LEU   A 1 236 ? 147.871 113.956 186.044 1.00 137.96 ? 285 LEU   A CB  1 
ATOM   1835 C  CG  . LEU   A 1 236 ? 147.418 115.393 186.303 1.00 140.80 ? 285 LEU   A CG  1 
ATOM   1836 C  CD1 . LEU   A 1 236 ? 147.521 116.202 185.026 1.00 142.20 ? 285 LEU   A CD1 1 
ATOM   1837 C  CD2 . LEU   A 1 236 ? 146.001 115.433 186.852 1.00 142.59 ? 285 LEU   A CD2 1 
ATOM   1838 N  N   . LEU   A 1 237 ? 148.586 110.890 186.395 1.00 152.82 ? 286 LEU   A N   1 
ATOM   1839 C  CA  . LEU   A 1 237 ? 148.825 109.592 185.773 1.00 151.83 ? 286 LEU   A CA  1 
ATOM   1840 C  C   . LEU   A 1 237 ? 147.943 108.510 186.384 1.00 154.34 ? 286 LEU   A C   1 
ATOM   1841 O  O   . LEU   A 1 237 ? 147.363 107.693 185.659 1.00 153.74 ? 286 LEU   A O   1 
ATOM   1842 C  CB  . LEU   A 1 237 ? 150.300 109.215 185.892 1.00 147.36 ? 286 LEU   A CB  1 
ATOM   1843 C  CG  . LEU   A 1 237 ? 151.177 109.617 184.706 1.00 147.81 ? 286 LEU   A CG  1 
ATOM   1844 C  CD1 . LEU   A 1 237 ? 152.638 109.319 184.995 1.00 151.40 ? 286 LEU   A CD1 1 
ATOM   1845 C  CD2 . LEU   A 1 237 ? 150.720 108.918 183.438 1.00 150.79 ? 286 LEU   A CD2 1 
ATOM   1846 N  N   . ASP   A 1 238 ? 147.830 108.485 187.714 1.00 163.00 ? 287 ASP   A N   1 
ATOM   1847 C  CA  . ASP   A 1 238 ? 146.995 107.479 188.363 1.00 162.15 ? 287 ASP   A CA  1 
ATOM   1848 C  C   . ASP   A 1 238 ? 145.520 107.689 188.043 1.00 161.12 ? 287 ASP   A C   1 
ATOM   1849 O  O   . ASP   A 1 238 ? 144.790 106.723 187.794 1.00 163.99 ? 287 ASP   A O   1 
ATOM   1850 C  CB  . ASP   A 1 238 ? 147.222 107.500 189.874 1.00 162.84 ? 287 ASP   A CB  1 
ATOM   1851 C  CG  . ASP   A 1 238 ? 148.674 107.285 190.248 1.00 164.86 ? 287 ASP   A CG  1 
ATOM   1852 O  OD1 . ASP   A 1 238 ? 149.378 106.564 189.510 1.00 163.96 ? 287 ASP   A OD1 1 
ATOM   1853 O  OD2 . ASP   A 1 238 ? 149.112 107.837 191.279 1.00 165.55 ? 287 ASP   A OD2 1 
ATOM   1854 N  N   . ALA   A 1 239 ? 145.064 108.938 188.046 1.00 153.87 ? 288 ALA   A N   1 
ATOM   1855 C  CA  . ALA   A 1 239 ? 143.666 109.226 187.769 1.00 154.94 ? 288 ALA   A CA  1 
ATOM   1856 C  C   . ALA   A 1 239 ? 143.340 108.947 186.309 1.00 157.18 ? 288 ALA   A C   1 
ATOM   1857 O  O   . ALA   A 1 239 ? 144.138 109.228 185.410 1.00 154.73 ? 288 ALA   A O   1 
ATOM   1858 C  CB  . ALA   A 1 239 ? 143.345 110.680 188.112 1.00 152.45 ? 288 ALA   A CB  1 
ATOM   1859 N  N   . THR   A 1 240 ? 142.157 108.390 186.077 1.00 173.49 ? 289 THR   A N   1 
ATOM   1860 C  CA  . THR   A 1 240 ? 141.679 108.068 184.743 1.00 172.52 ? 289 THR   A CA  1 
ATOM   1861 C  C   . THR   A 1 240 ? 140.468 108.931 184.415 1.00 171.04 ? 289 THR   A C   1 
ATOM   1862 O  O   . THR   A 1 240 ? 140.001 109.728 185.233 1.00 168.53 ? 289 THR   A O   1 
ATOM   1863 C  CB  . THR   A 1 240 ? 141.312 106.583 184.625 1.00 171.64 ? 289 THR   A CB  1 
ATOM   1864 O  OG1 . THR   A 1 240 ? 140.478 106.208 185.728 1.00 173.20 ? 289 THR   A OG1 1 
ATOM   1865 C  CG2 . THR   A 1 240 ? 142.566 105.724 184.636 1.00 169.33 ? 289 THR   A CG2 1 
ATOM   1866 N  N   . TYR   A 1 241 ? 139.962 108.764 183.198 1.00 170.74 ? 290 TYR   A N   1 
ATOM   1867 C  CA  . TYR   A 1 241 ? 138.760 109.471 182.793 1.00 171.09 ? 290 TYR   A CA  1 
ATOM   1868 C  C   . TYR   A 1 241 ? 137.546 108.922 183.536 1.00 172.66 ? 290 TYR   A C   1 
ATOM   1869 O  O   . TYR   A 1 241 ? 137.598 107.870 184.179 1.00 172.23 ? 290 TYR   A O   1 
ATOM   1870 C  CB  . TYR   A 1 241 ? 138.550 109.353 181.285 1.00 169.55 ? 290 TYR   A CB  1 
ATOM   1871 C  CG  . TYR   A 1 241 ? 139.032 110.551 180.505 1.00 167.43 ? 290 TYR   A CG  1 
ATOM   1872 C  CD1 . TYR   A 1 241 ? 140.372 110.701 180.187 1.00 168.06 ? 290 TYR   A CD1 1 
ATOM   1873 C  CD2 . TYR   A 1 241 ? 138.146 111.532 180.088 1.00 168.71 ? 290 TYR   A CD2 1 
ATOM   1874 C  CE1 . TYR   A 1 241 ? 140.818 111.794 179.474 1.00 167.46 ? 290 TYR   A CE1 1 
ATOM   1875 C  CE2 . TYR   A 1 241 ? 138.582 112.629 179.376 1.00 170.97 ? 290 TYR   A CE2 1 
ATOM   1876 C  CZ  . TYR   A 1 241 ? 139.919 112.755 179.072 1.00 169.40 ? 290 TYR   A CZ  1 
ATOM   1877 O  OH  . TYR   A 1 241 ? 140.361 113.846 178.361 1.00 169.86 ? 290 TYR   A OH  1 
ATOM   1878 N  N   . LYS   A 1 242 ? 136.439 109.662 183.448 1.00 184.09 ? 291 LYS   A N   1 
ATOM   1879 C  CA  . LYS   A 1 242 ? 135.199 109.203 184.066 1.00 185.38 ? 291 LYS   A CA  1 
ATOM   1880 C  C   . LYS   A 1 242 ? 134.724 107.901 183.434 1.00 187.33 ? 291 LYS   A C   1 
ATOM   1881 O  O   . LYS   A 1 242 ? 134.259 106.994 184.136 1.00 187.30 ? 291 LYS   A O   1 
ATOM   1882 C  CB  . LYS   A 1 242 ? 134.124 110.284 183.953 1.00 186.00 ? 291 LYS   A CB  1 
ATOM   1883 C  CG  . LYS   A 1 242 ? 132.706 109.783 184.170 1.00 185.78 ? 291 LYS   A CG  1 
ATOM   1884 C  CD  . LYS   A 1 242 ? 131.747 110.935 184.415 1.00 185.94 ? 291 LYS   A CD  1 
ATOM   1885 C  CE  . LYS   A 1 242 ? 131.764 111.365 185.873 1.00 185.57 ? 291 LYS   A CE  1 
ATOM   1886 N  NZ  . LYS   A 1 242 ? 131.444 112.810 186.028 1.00 183.68 ? 291 LYS   A NZ  1 
ATOM   1887 N  N   . ASP   A 1 243 ? 134.833 107.790 182.108 1.00 185.89 ? 292 ASP   A N   1 
ATOM   1888 C  CA  . ASP   A 1 243 ? 134.469 106.546 181.438 1.00 183.98 ? 292 ASP   A CA  1 
ATOM   1889 C  C   . ASP   A 1 243 ? 135.375 105.400 181.872 1.00 185.08 ? 292 ASP   A C   1 
ATOM   1890 O  O   . ASP   A 1 243 ? 134.905 104.278 182.096 1.00 184.05 ? 292 ASP   A O   1 
ATOM   1891 C  CB  . ASP   A 1 243 ? 134.524 106.733 179.923 1.00 183.42 ? 292 ASP   A CB  1 
ATOM   1892 C  CG  . ASP   A 1 243 ? 135.778 107.452 179.472 1.00 184.54 ? 292 ASP   A CG  1 
ATOM   1893 O  OD1 . ASP   A 1 243 ? 135.789 108.700 179.495 1.00 183.35 ? 292 ASP   A OD1 1 
ATOM   1894 O  OD2 . ASP   A 1 243 ? 136.752 106.769 179.094 1.00 184.88 ? 292 ASP   A OD2 1 
ATOM   1895 N  N   . GLY   A 1 244 ? 136.674 105.661 181.998 1.00 184.52 ? 293 GLY   A N   1 
ATOM   1896 C  CA  . GLY   A 1 244 ? 137.605 104.646 182.449 1.00 183.85 ? 293 GLY   A CA  1 
ATOM   1897 C  C   . GLY   A 1 244 ? 138.874 104.566 181.626 1.00 182.13 ? 293 GLY   A C   1 
ATOM   1898 O  O   . GLY   A 1 244 ? 139.761 103.760 181.923 1.00 181.95 ? 293 GLY   A O   1 
ATOM   1899 N  N   . ARG   A 1 245 ? 138.972 105.390 180.592 1.00 174.59 ? 294 ARG   A N   1 
ATOM   1900 C  CA  . ARG   A 1 245 ? 140.156 105.378 179.741 1.00 174.64 ? 294 ARG   A CA  1 
ATOM   1901 C  C   . ARG   A 1 245 ? 141.346 105.967 180.490 1.00 175.36 ? 294 ARG   A C   1 
ATOM   1902 O  O   . ARG   A 1 245 ? 141.244 107.075 181.029 1.00 175.67 ? 294 ARG   A O   1 
ATOM   1903 C  CB  . ARG   A 1 245 ? 139.903 106.167 178.459 1.00 175.64 ? 294 ARG   A CB  1 
ATOM   1904 C  CG  . ARG   A 1 245 ? 141.166 106.494 177.682 1.00 175.23 ? 294 ARG   A CG  1 
ATOM   1905 C  CD  . ARG   A 1 245 ? 141.351 107.994 177.530 1.00 175.38 ? 294 ARG   A CD  1 
ATOM   1906 N  NE  . ARG   A 1 245 ? 140.546 108.541 176.445 1.00 175.36 ? 294 ARG   A NE  1 
ATOM   1907 C  CZ  . ARG   A 1 245 ? 140.901 108.526 175.168 1.00 175.80 ? 294 ARG   A CZ  1 
ATOM   1908 N  NH1 . ARG   A 1 245 ? 142.045 107.990 174.775 1.00 176.31 ? 294 ARG   A NH1 1 
ATOM   1909 N  NH2 . ARG   A 1 245 ? 140.088 109.062 174.262 1.00 175.11 ? 294 ARG   A NH2 1 
ATOM   1910 N  N   . PRO   A 1 246 ? 142.472 105.259 180.565 1.00 172.33 ? 295 PRO   A N   1 
ATOM   1911 C  CA  . PRO   A 1 246 ? 143.668 105.846 181.185 1.00 173.42 ? 295 PRO   A CA  1 
ATOM   1912 C  C   . PRO   A 1 246 ? 144.109 107.099 180.443 1.00 172.17 ? 295 PRO   A C   1 
ATOM   1913 O  O   . PRO   A 1 246 ? 143.997 107.192 179.219 1.00 171.20 ? 295 PRO   A O   1 
ATOM   1914 C  CB  . PRO   A 1 246 ? 144.721 104.735 181.080 1.00 171.94 ? 295 PRO   A CB  1 
ATOM   1915 C  CG  . PRO   A 1 246 ? 144.057 103.559 180.455 1.00 170.71 ? 295 PRO   A CG  1 
ATOM   1916 C  CD  . PRO   A 1 246 ? 142.599 103.814 180.320 1.00 169.81 ? 295 PRO   A CD  1 
ATOM   1917 N  N   . LEU   A 1 247 ? 144.615 108.068 181.201 1.00 150.74 ? 296 LEU   A N   1 
ATOM   1918 C  CA  . LEU   A 1 247 ? 145.075 109.320 180.614 1.00 147.05 ? 296 LEU   A CA  1 
ATOM   1919 C  C   . LEU   A 1 247 ? 146.317 109.070 179.768 1.00 153.41 ? 296 LEU   A C   1 
ATOM   1920 O  O   . LEU   A 1 247 ? 147.290 108.474 180.242 1.00 155.17 ? 296 LEU   A O   1 
ATOM   1921 C  CB  . LEU   A 1 247 ? 145.369 110.339 181.711 1.00 148.53 ? 296 LEU   A CB  1 
ATOM   1922 C  CG  . LEU   A 1 247 ? 144.389 111.505 181.841 1.00 149.96 ? 296 LEU   A CG  1 
ATOM   1923 C  CD1 . LEU   A 1 247 ? 144.863 112.482 182.903 1.00 149.27 ? 296 LEU   A CD1 1 
ATOM   1924 C  CD2 . LEU   A 1 247 ? 144.210 112.206 180.509 1.00 148.32 ? 296 LEU   A CD2 1 
ATOM   1925 N  N   . THR   A 1 248 ? 146.284 109.521 178.517 1.00 156.54 ? 297 THR   A N   1 
ATOM   1926 C  CA  . THR   A 1 248 ? 147.432 109.364 177.639 1.00 155.11 ? 297 THR   A CA  1 
ATOM   1927 C  C   . THR   A 1 248 ? 148.536 110.348 178.019 1.00 150.50 ? 297 THR   A C   1 
ATOM   1928 O  O   . THR   A 1 248 ? 148.299 111.381 178.653 1.00 150.90 ? 297 THR   A O   1 
ATOM   1929 C  CB  . THR   A 1 248 ? 147.032 109.568 176.177 1.00 154.77 ? 297 THR   A CB  1 
ATOM   1930 O  OG1 . THR   A 1 248 ? 147.102 110.960 175.850 1.00 154.41 ? 297 THR   A OG1 1 
ATOM   1931 C  CG2 . THR   A 1 248 ? 145.619 109.064 175.936 1.00 151.68 ? 297 THR   A CG2 1 
ATOM   1932 N  N   . ASP   A 1 249 ? 149.763 110.007 177.621 1.00 149.92 ? 298 ASP   A N   1 
ATOM   1933 C  CA  . ASP   A 1 249 ? 150.905 110.862 177.930 1.00 154.80 ? 298 ASP   A CA  1 
ATOM   1934 C  C   . ASP   A 1 249 ? 150.785 112.215 177.240 1.00 155.38 ? 298 ASP   A C   1 
ATOM   1935 O  O   . ASP   A 1 249 ? 151.158 113.246 177.813 1.00 160.30 ? 298 ASP   A O   1 
ATOM   1936 C  CB  . ASP   A 1 249 ? 152.204 110.164 177.534 1.00 155.17 ? 298 ASP   A CB  1 
ATOM   1937 C  CG  . ASP   A 1 249 ? 152.449 108.899 178.331 1.00 157.50 ? 298 ASP   A CG  1 
ATOM   1938 O  OD1 . ASP   A 1 249 ? 151.482 108.368 178.916 1.00 155.90 ? 298 ASP   A OD1 1 
ATOM   1939 O  OD2 . ASP   A 1 249 ? 153.608 108.436 178.374 1.00 158.25 ? 298 ASP   A OD2 1 
ATOM   1940 N  N   . ASP   A 1 250 ? 150.270 112.233 176.009 1.00 152.99 ? 299 ASP   A N   1 
ATOM   1941 C  CA  . ASP   A 1 250 ? 150.051 113.499 175.317 1.00 154.54 ? 299 ASP   A CA  1 
ATOM   1942 C  C   . ASP   A 1 250 ? 149.061 114.372 176.078 1.00 155.65 ? 299 ASP   A C   1 
ATOM   1943 O  O   . ASP   A 1 250 ? 149.281 115.577 176.258 1.00 159.61 ? 299 ASP   A O   1 
ATOM   1944 C  CB  . ASP   A 1 250 ? 149.557 113.238 173.895 1.00 156.65 ? 299 ASP   A CB  1 
ATOM   1945 C  CG  . ASP   A 1 250 ? 149.027 114.489 173.224 1.00 157.24 ? 299 ASP   A CG  1 
ATOM   1946 O  OD1 . ASP   A 1 250 ? 147.816 114.767 173.350 1.00 155.90 ? 299 ASP   A OD1 1 
ATOM   1947 O  OD2 . ASP   A 1 250 ? 149.821 115.194 172.568 1.00 157.81 ? 299 ASP   A OD2 1 
ATOM   1948 N  N   . GLU   A 1 251 ? 147.961 113.774 176.539 1.00 135.58 ? 300 GLU   A N   1 
ATOM   1949 C  CA  . GLU   A 1 251 ? 146.975 114.533 177.298 1.00 131.43 ? 300 GLU   A CA  1 
ATOM   1950 C  C   . GLU   A 1 251 ? 147.561 115.048 178.605 1.00 135.77 ? 300 GLU   A C   1 
ATOM   1951 O  O   . GLU   A 1 251 ? 147.308 116.191 178.992 1.00 139.10 ? 300 GLU   A O   1 
ATOM   1952 C  CB  . GLU   A 1 251 ? 145.737 113.677 177.562 1.00 136.28 ? 300 GLU   A CB  1 
ATOM   1953 C  CG  . GLU   A 1 251 ? 144.942 113.334 176.313 1.00 139.96 ? 300 GLU   A CG  1 
ATOM   1954 C  CD  . GLU   A 1 251 ? 143.621 112.663 176.631 1.00 140.36 ? 300 GLU   A CD  1 
ATOM   1955 O  OE1 . GLU   A 1 251 ? 143.620 111.444 176.895 1.00 138.08 ? 300 GLU   A OE1 1 
ATOM   1956 O  OE2 . GLU   A 1 251 ? 142.583 113.357 176.617 1.00 143.02 ? 300 GLU   A OE2 1 
ATOM   1957 N  N   . VAL   A 1 252 ? 148.346 114.220 179.299 1.00 123.01 ? 301 VAL   A N   1 
ATOM   1958 C  CA  . VAL   A 1 252 ? 148.947 114.646 180.562 1.00 118.41 ? 301 VAL   A CA  1 
ATOM   1959 C  C   . VAL   A 1 252 ? 149.907 115.807 180.333 1.00 117.33 ? 301 VAL   A C   1 
ATOM   1960 O  O   . VAL   A 1 252 ? 149.923 116.786 181.096 1.00 124.89 ? 301 VAL   A O   1 
ATOM   1961 C  CB  . VAL   A 1 252 ? 149.646 113.458 181.248 1.00 109.84 ? 301 VAL   A CB  1 
ATOM   1962 C  CG1 . VAL   A 1 252 ? 150.492 113.938 182.411 1.00 118.38 ? 301 VAL   A CG1 1 
ATOM   1963 C  CG2 . VAL   A 1 252 ? 148.620 112.446 181.720 1.00 117.60 ? 301 VAL   A CG2 1 
ATOM   1964 N  N   . ALA   A 1 253 ? 150.726 115.714 179.283 1.00 111.22 ? 302 ALA   A N   1 
ATOM   1965 C  CA  . ALA   A 1 253 ? 151.624 116.812 178.954 1.00 109.27 ? 302 ALA   A CA  1 
ATOM   1966 C  C   . ALA   A 1 253 ? 150.844 118.083 178.661 1.00 110.39 ? 302 ALA   A C   1 
ATOM   1967 O  O   . ALA   A 1 253 ? 151.210 119.166 179.131 1.00 122.93 ? 302 ALA   A O   1 
ATOM   1968 C  CB  . ALA   A 1 253 ? 152.502 116.434 177.762 1.00 114.24 ? 302 ALA   A CB  1 
ATOM   1969 N  N   . GLY   A 1 254 ? 149.763 117.973 177.890 1.00 110.85 ? 303 GLY   A N   1 
ATOM   1970 C  CA  . GLY   A 1 254 ? 148.936 119.140 177.639 1.00 113.90 ? 303 GLY   A CA  1 
ATOM   1971 C  C   . GLY   A 1 254 ? 148.382 119.740 178.916 1.00 112.94 ? 303 GLY   A C   1 
ATOM   1972 O  O   . GLY   A 1 254 ? 148.423 120.957 179.110 1.00 117.30 ? 303 GLY   A O   1 
ATOM   1973 N  N   . MET   A 1 255 ? 147.886 118.888 179.817 1.00 130.22 ? 304 MET   A N   1 
ATOM   1974 C  CA  . MET   A 1 255 ? 147.366 119.360 181.097 1.00 129.70 ? 304 MET   A CA  1 
ATOM   1975 C  C   . MET   A 1 255 ? 148.413 120.167 181.846 1.00 131.79 ? 304 MET   A C   1 
ATOM   1976 O  O   . MET   A 1 255 ? 148.137 121.268 182.332 1.00 136.51 ? 304 MET   A O   1 
ATOM   1977 C  CB  . MET   A 1 255 ? 146.922 118.180 181.962 1.00 132.21 ? 304 MET   A CB  1 
ATOM   1978 C  CG  . MET   A 1 255 ? 145.857 117.280 181.383 1.00 134.44 ? 304 MET   A CG  1 
ATOM   1979 S  SD  . MET   A 1 255 ? 144.750 116.660 182.658 1.00 146.51 ? 304 MET   A SD  1 
ATOM   1980 C  CE  . MET   A 1 255 ? 143.444 115.969 181.656 1.00 137.26 ? 304 MET   A CE  1 
ATOM   1981 N  N   . LEU   A 1 256 ? 149.628 119.631 181.950 1.00 114.98 ? 305 LEU   A N   1 
ATOM   1982 C  CA  . LEU   A 1 256 ? 150.615 120.264 182.819 1.00 111.00 ? 305 LEU   A CA  1 
ATOM   1983 C  C   . LEU   A 1 256 ? 151.223 121.517 182.192 1.00 114.66 ? 305 LEU   A C   1 
ATOM   1984 O  O   . LEU   A 1 256 ? 151.451 122.512 182.895 1.00 120.19 ? 305 LEU   A O   1 
ATOM   1985 C  CB  . LEU   A 1 256 ? 151.686 119.249 183.205 1.00 107.64 ? 305 LEU   A CB  1 
ATOM   1986 C  CG  . LEU   A 1 256 ? 151.066 118.109 184.018 1.00 112.25 ? 305 LEU   A CG  1 
ATOM   1987 C  CD1 . LEU   A 1 256 ? 152.107 117.151 184.555 1.00 111.71 ? 305 LEU   A CD1 1 
ATOM   1988 C  CD2 . LEU   A 1 256 ? 150.230 118.671 185.155 1.00 118.06 ? 305 LEU   A CD2 1 
ATOM   1989 N  N   . ILE   A 1 257 ? 151.488 121.506 180.882 1.00 105.80 ? 306 ILE   A N   1 
ATOM   1990 C  CA  . ILE   A 1 257 ? 151.942 122.728 180.225 1.00 101.69 ? 306 ILE   A CA  1 
ATOM   1991 C  C   . ILE   A 1 257 ? 150.826 123.750 180.075 1.00 110.90 ? 306 ILE   A C   1 
ATOM   1992 O  O   . ILE   A 1 257 ? 151.100 124.913 179.765 1.00 118.51 ? 306 ILE   A O   1 
ATOM   1993 C  CB  . ILE   A 1 257 ? 152.583 122.444 178.849 1.00 102.12 ? 306 ILE   A CB  1 
ATOM   1994 C  CG1 . ILE   A 1 257 ? 153.438 121.181 178.892 1.00 114.78 ? 306 ILE   A CG1 1 
ATOM   1995 C  CG2 . ILE   A 1 257 ? 153.462 123.600 178.406 1.00 107.68 ? 306 ILE   A CG2 1 
ATOM   1996 C  CD1 . ILE   A 1 257 ? 153.523 120.467 177.561 1.00 120.53 ? 306 ILE   A CD1 1 
ATOM   1997 N  N   . GLY   A 1 258 ? 149.573 123.359 180.292 1.00 117.97 ? 307 GLY   A N   1 
ATOM   1998 C  CA  . GLY   A 1 258 ? 148.526 124.349 180.421 1.00 116.30 ? 307 GLY   A CA  1 
ATOM   1999 C  C   . GLY   A 1 258 ? 148.511 124.941 181.813 1.00 111.79 ? 307 GLY   A C   1 
ATOM   2000 O  O   . GLY   A 1 258 ? 148.431 126.161 181.983 1.00 111.86 ? 307 GLY   A O   1 
ATOM   2001 N  N   . LEU   A 1 259 ? 148.617 124.068 182.816 1.00 103.98 ? 308 LEU   A N   1 
ATOM   2002 C  CA  . LEU   A 1 259 ? 148.600 124.504 184.207 1.00 103.92 ? 308 LEU   A CA  1 
ATOM   2003 C  C   . LEU   A 1 259 ? 149.706 125.511 184.486 1.00 108.30 ? 308 LEU   A C   1 
ATOM   2004 O  O   . LEU   A 1 259 ? 149.450 126.614 184.986 1.00 123.05 ? 308 LEU   A O   1 
ATOM   2005 C  CB  . LEU   A 1 259 ? 148.748 123.291 185.125 1.00 109.66 ? 308 LEU   A CB  1 
ATOM   2006 C  CG  . LEU   A 1 259 ? 147.827 123.179 186.335 1.00 110.03 ? 308 LEU   A CG  1 
ATOM   2007 C  CD1 . LEU   A 1 259 ? 146.379 123.287 185.910 1.00 116.30 ? 308 LEU   A CD1 1 
ATOM   2008 C  CD2 . LEU   A 1 259 ? 148.079 121.880 187.078 1.00 109.75 ? 308 LEU   A CD2 1 
ATOM   2009 N  N   . LEU   A 1 260 ? 150.947 125.153 184.155 1.00 99.44  ? 309 LEU   A N   1 
ATOM   2010 C  CA  . LEU   A 1 260 ? 152.068 126.024 184.495 1.00 98.08  ? 309 LEU   A CA  1 
ATOM   2011 C  C   . LEU   A 1 260 ? 152.049 127.307 183.673 1.00 101.84 ? 309 LEU   A C   1 
ATOM   2012 O  O   . LEU   A 1 260 ? 152.307 128.397 184.203 1.00 116.83 ? 309 LEU   A O   1 
ATOM   2013 C  CB  . LEU   A 1 260 ? 153.383 125.267 184.317 1.00 102.49 ? 309 LEU   A CB  1 
ATOM   2014 C  CG  . LEU   A 1 260 ? 154.692 126.051 184.361 1.00 113.76 ? 309 LEU   A CG  1 
ATOM   2015 C  CD1 . LEU   A 1 260 ? 155.785 125.175 184.916 1.00 119.43 ? 309 LEU   A CD1 1 
ATOM   2016 C  CD2 . LEU   A 1 260 ? 155.076 126.496 182.960 1.00 113.46 ? 309 LEU   A CD2 1 
ATOM   2017 N  N   . LEU   A 1 261 ? 151.764 127.199 182.374 1.00 103.96 ? 310 LEU   A N   1 
ATOM   2018 C  CA  . LEU   A 1 261 ? 151.748 128.384 181.528 1.00 103.48 ? 310 LEU   A CA  1 
ATOM   2019 C  C   . LEU   A 1 261 ? 150.602 129.316 181.892 1.00 112.73 ? 310 LEU   A C   1 
ATOM   2020 O  O   . LEU   A 1 261 ? 150.673 130.518 181.611 1.00 118.42 ? 310 LEU   A O   1 
ATOM   2021 C  CB  . LEU   A 1 261 ? 151.660 127.980 180.059 1.00 105.48 ? 310 LEU   A CB  1 
ATOM   2022 C  CG  . LEU   A 1 261 ? 152.101 129.028 179.041 1.00 109.22 ? 310 LEU   A CG  1 
ATOM   2023 C  CD1 . LEU   A 1 261 ? 153.463 129.586 179.412 1.00 111.24 ? 310 LEU   A CD1 1 
ATOM   2024 C  CD2 . LEU   A 1 261 ? 152.123 128.429 177.646 1.00 114.81 ? 310 LEU   A CD2 1 
ATOM   2025 N  N   . ALA   A 1 262 ? 149.636 128.815 182.660 1.00 103.40 ? 311 ALA   A N   1 
ATOM   2026 C  CA  . ALA   A 1 262 ? 148.465 129.662 182.965 1.00 100.45 ? 311 ALA   A CA  1 
ATOM   2027 C  C   . ALA   A 1 262 ? 148.660 130.370 184.294 1.00 100.30 ? 311 ALA   A C   1 
ATOM   2028 O  O   . ALA   A 1 262 ? 147.880 131.266 184.600 1.00 102.10 ? 311 ALA   A O   1 
ATOM   2029 C  CB  . ALA   A 1 262 ? 147.217 128.850 182.967 1.00 100.54 ? 311 ALA   A CB  1 
ATOM   2030 N  N   . GLY   A 1 263 ? 149.677 129.976 185.040 1.00 102.57 ? 312 GLY   A N   1 
ATOM   2031 C  CA  . GLY   A 1 263 ? 149.916 130.582 186.358 1.00 99.14  ? 312 GLY   A CA  1 
ATOM   2032 C  C   . GLY   A 1 263 ? 151.248 131.294 186.419 1.00 107.10 ? 312 GLY   A C   1 
ATOM   2033 O  O   . GLY   A 1 263 ? 151.506 131.933 187.430 1.00 115.49 ? 312 GLY   A O   1 
ATOM   2034 N  N   . GLN   A 1 264 ? 152.065 131.197 185.376 1.00 109.80 ? 313 GLN   A N   1 
ATOM   2035 C  CA  . GLN   A 1 264 ? 153.417 131.798 185.419 1.00 101.28 ? 313 GLN   A CA  1 
ATOM   2036 C  C   . GLN   A 1 264 ? 153.246 133.293 185.293 1.00 108.45 ? 313 GLN   A C   1 
ATOM   2037 O  O   . GLN   A 1 264 ? 153.866 134.016 186.070 1.00 124.11 ? 313 GLN   A O   1 
ATOM   2038 C  CB  . GLN   A 1 264 ? 154.275 131.409 184.226 1.00 101.82 ? 313 GLN   A CB  1 
ATOM   2039 C  CG  . GLN   A 1 264 ? 155.656 132.039 184.250 1.00 108.50 ? 313 GLN   A CG  1 
ATOM   2040 C  CD  . GLN   A 1 264 ? 156.421 131.722 182.991 1.00 117.20 ? 313 GLN   A CD  1 
ATOM   2041 O  OE1 . GLN   A 1 264 ? 156.006 130.894 182.185 1.00 119.07 ? 313 GLN   A OE1 1 
ATOM   2042 N  NE2 . GLN   A 1 264 ? 157.553 132.383 182.816 1.00 112.12 ? 313 GLN   A NE2 1 
ATOM   2043 N  N   . HIS   A 1 265 ? 152.429 133.765 184.350 1.00 112.17 ? 314 HIS   A N   1 
ATOM   2044 C  CA  . HIS   A 1 265 ? 152.356 135.238 184.116 1.00 120.16 ? 314 HIS   A CA  1 
ATOM   2045 C  C   . HIS   A 1 265 ? 151.149 135.893 184.780 1.00 114.05 ? 314 HIS   A C   1 
ATOM   2046 O  O   . HIS   A 1 265 ? 151.122 137.119 184.829 1.00 108.13 ? 314 HIS   A O   1 
ATOM   2047 C  CB  . HIS   A 1 265 ? 152.380 135.577 182.627 1.00 115.45 ? 314 HIS   A CB  1 
ATOM   2048 C  CG  . HIS   A 1 265 ? 153.706 136.058 182.150 1.00 119.13 ? 314 HIS   A CG  1 
ATOM   2049 N  ND1 . HIS   A 1 265 ? 154.647 135.211 181.602 1.00 125.46 ? 314 HIS   A ND1 1 
ATOM   2050 C  CD2 . HIS   A 1 265 ? 154.256 137.290 182.145 1.00 115.16 ? 314 HIS   A CD2 1 
ATOM   2051 C  CE1 . HIS   A 1 265 ? 155.719 135.899 181.275 1.00 123.30 ? 314 HIS   A CE1 1 
ATOM   2052 N  NE2 . HIS   A 1 265 ? 155.504 137.178 181.599 1.00 125.02 ? 314 HIS   A NE2 1 
ATOM   2053 N  N   . THR   A 1 266 ? 150.183 135.107 185.243 1.00 112.68 ? 315 THR   A N   1 
ATOM   2054 C  CA  . THR   A 1 266 ? 149.020 135.675 185.958 1.00 103.68 ? 315 THR   A CA  1 
ATOM   2055 C  C   . THR   A 1 266 ? 149.356 135.742 187.437 1.00 102.42 ? 315 THR   A C   1 
ATOM   2056 O  O   . THR   A 1 266 ? 148.535 136.230 188.195 1.00 106.13 ? 315 THR   A O   1 
ATOM   2057 C  CB  . THR   A 1 266 ? 147.778 134.808 185.768 1.00 106.07 ? 315 THR   A CB  1 
ATOM   2058 O  OG1 . THR   A 1 266 ? 148.129 133.493 186.188 1.00 116.22 ? 315 THR   A OG1 1 
ATOM   2059 C  CG2 . THR   A 1 266 ? 147.286 134.772 184.340 1.00 103.72 ? 315 THR   A CG2 1 
ATOM   2060 N  N   . SER   A 1 267 ? 150.517 135.226 187.818 1.00 97.92  ? 316 SER   A N   1 
ATOM   2061 C  CA  . SER   A 1 267 ? 150.927 135.243 189.239 1.00 100.95 ? 316 SER   A CA  1 
ATOM   2062 C  C   . SER   A 1 267 ? 152.166 136.123 189.413 1.00 106.53 ? 316 SER   A C   1 
ATOM   2063 O  O   . SER   A 1 267 ? 152.345 136.651 190.513 1.00 110.66 ? 316 SER   A O   1 
ATOM   2064 C  CB  . SER   A 1 267 ? 151.161 133.868 189.754 1.00 95.15  ? 316 SER   A CB  1 
ATOM   2065 O  OG  . SER   A 1 267 ? 151.303 133.873 191.161 1.00 112.19 ? 316 SER   A OG  1 
ATOM   2066 N  N   . SER   A 1 268 ? 152.986 136.286 188.374 1.00 105.25 ? 317 SER   A N   1 
ATOM   2067 C  CA  . SER   A 1 268 ? 154.141 137.174 188.487 1.00 100.49 ? 317 SER   A CA  1 
ATOM   2068 C  C   . SER   A 1 268 ? 153.713 138.634 188.566 1.00 104.81 ? 317 SER   A C   1 
ATOM   2069 O  O   . SER   A 1 268 ? 154.224 139.397 189.398 1.00 117.66 ? 317 SER   A O   1 
ATOM   2070 C  CB  . SER   A 1 268 ? 155.087 136.958 187.308 1.00 98.70  ? 317 SER   A CB  1 
ATOM   2071 O  OG  . SER   A 1 268 ? 154.418 137.160 186.077 1.00 104.59 ? 317 SER   A OG  1 
ATOM   2072 N  N   . THR   A 1 269 ? 152.772 139.041 187.712 1.00 104.56 ? 318 THR   A N   1 
ATOM   2073 C  CA  . THR   A 1 269 ? 152.326 140.429 187.714 1.00 107.82 ? 318 THR   A CA  1 
ATOM   2074 C  C   . THR   A 1 269 ? 151.587 140.775 189.000 1.00 112.66 ? 318 THR   A C   1 
ATOM   2075 O  O   . THR   A 1 269 ? 151.744 141.880 189.527 1.00 119.19 ? 318 THR   A O   1 
ATOM   2076 C  CB  . THR   A 1 269 ? 151.446 140.702 186.499 1.00 112.53 ? 318 THR   A CB  1 
ATOM   2077 O  OG1 . THR   A 1 269 ? 150.149 140.132 186.710 1.00 117.23 ? 318 THR   A OG1 1 
ATOM   2078 C  CG2 . THR   A 1 269 ? 152.071 140.094 185.261 1.00 118.57 ? 318 THR   A CG2 1 
ATOM   2079 N  N   . THR   A 1 270 ? 150.773 139.852 189.516 1.00 110.12 ? 319 THR   A N   1 
ATOM   2080 C  CA  . THR   A 1 270 ? 150.099 140.100 190.786 1.00 109.46 ? 319 THR   A CA  1 
ATOM   2081 C  C   . THR   A 1 270 ? 151.103 140.259 191.920 1.00 118.13 ? 319 THR   A C   1 
ATOM   2082 O  O   . THR   A 1 270 ? 150.964 141.155 192.763 1.00 125.11 ? 319 THR   A O   1 
ATOM   2083 C  CB  . THR   A 1 270 ? 149.116 138.970 191.092 1.00 103.47 ? 319 THR   A CB  1 
ATOM   2084 O  OG1 . THR   A 1 270 ? 147.918 139.165 190.334 1.00 107.96 ? 319 THR   A OG1 1 
ATOM   2085 C  CG2 . THR   A 1 270 ? 148.769 138.937 192.570 1.00 104.57 ? 319 THR   A CG2 1 
ATOM   2086 N  N   . SER   A 1 271 ? 152.130 139.405 191.953 1.00 111.63 ? 320 SER   A N   1 
ATOM   2087 C  CA  . SER   A 1 271 ? 153.149 139.527 192.989 1.00 102.84 ? 320 SER   A CA  1 
ATOM   2088 C  C   . SER   A 1 271 ? 153.885 140.858 192.885 1.00 114.39 ? 320 SER   A C   1 
ATOM   2089 O  O   . SER   A 1 271 ? 154.114 141.530 193.898 1.00 122.21 ? 320 SER   A O   1 
ATOM   2090 C  CB  . SER   A 1 271 ? 154.129 138.359 192.898 1.00 107.88 ? 320 SER   A CB  1 
ATOM   2091 O  OG  . SER   A 1 271 ? 153.456 137.121 193.032 1.00 115.04 ? 320 SER   A OG  1 
ATOM   2092 N  N   . ALA   A 1 272 ? 154.244 141.266 191.665 1.00 114.09 ? 321 ALA   A N   1 
ATOM   2093 C  CA  . ALA   A 1 272 ? 154.930 142.544 191.488 1.00 116.04 ? 321 ALA   A CA  1 
ATOM   2094 C  C   . ALA   A 1 272 ? 154.041 143.714 191.896 1.00 114.66 ? 321 ALA   A C   1 
ATOM   2095 O  O   . ALA   A 1 272 ? 154.508 144.674 192.525 1.00 116.08 ? 321 ALA   A O   1 
ATOM   2096 C  CB  . ALA   A 1 272 ? 155.387 142.698 190.039 1.00 114.03 ? 321 ALA   A CB  1 
ATOM   2097 N  N   . TRP   A 1 273 ? 152.756 143.657 191.537 1.00 113.97 ? 322 TRP   A N   1 
ATOM   2098 C  CA  . TRP   A 1 273 ? 151.838 144.729 191.899 1.00 114.60 ? 322 TRP   A CA  1 
ATOM   2099 C  C   . TRP   A 1 273 ? 151.686 144.835 193.408 1.00 120.61 ? 322 TRP   A C   1 
ATOM   2100 O  O   . TRP   A 1 273 ? 151.683 145.940 193.961 1.00 133.81 ? 322 TRP   A O   1 
ATOM   2101 C  CB  . TRP   A 1 273 ? 150.480 144.507 191.238 1.00 117.79 ? 322 TRP   A CB  1 
ATOM   2102 C  CG  . TRP   A 1 273 ? 150.403 145.014 189.833 1.00 125.69 ? 322 TRP   A CG  1 
ATOM   2103 C  CD1 . TRP   A 1 273 ? 149.998 144.316 188.734 1.00 127.99 ? 322 TRP   A CD1 1 
ATOM   2104 C  CD2 . TRP   A 1 273 ? 150.732 146.331 189.373 1.00 124.27 ? 322 TRP   A CD2 1 
ATOM   2105 N  NE1 . TRP   A 1 273 ? 150.058 145.112 187.618 1.00 124.16 ? 322 TRP   A NE1 1 
ATOM   2106 C  CE2 . TRP   A 1 273 ? 150.505 146.355 187.984 1.00 125.00 ? 322 TRP   A CE2 1 
ATOM   2107 C  CE3 . TRP   A 1 273 ? 151.196 147.491 189.999 1.00 122.45 ? 322 TRP   A CE3 1 
ATOM   2108 C  CZ2 . TRP   A 1 273 ? 150.727 147.490 187.212 1.00 125.52 ? 322 TRP   A CZ2 1 
ATOM   2109 C  CZ3 . TRP   A 1 273 ? 151.415 148.616 189.232 1.00 124.83 ? 322 TRP   A CZ3 1 
ATOM   2110 C  CH2 . TRP   A 1 273 ? 151.181 148.608 187.853 1.00 127.35 ? 322 TRP   A CH2 1 
ATOM   2111 N  N   . MET   A 1 274 ? 151.556 143.697 194.094 1.00 114.17 ? 323 MET   A N   1 
ATOM   2112 C  CA  . MET   A 1 274 ? 151.469 143.742 195.549 1.00 118.44 ? 323 MET   A CA  1 
ATOM   2113 C  C   . MET   A 1 274 ? 152.760 144.268 196.155 1.00 121.96 ? 323 MET   A C   1 
ATOM   2114 O  O   . MET   A 1 274 ? 152.733 144.994 197.154 1.00 125.85 ? 323 MET   A O   1 
ATOM   2115 C  CB  . MET   A 1 274 ? 151.137 142.365 196.116 1.00 109.32 ? 323 MET   A CB  1 
ATOM   2116 C  CG  . MET   A 1 274 ? 151.173 142.320 197.637 1.00 112.62 ? 323 MET   A CG  1 
ATOM   2117 S  SD  . MET   A 1 274 ? 151.108 140.649 198.298 1.00 139.34 ? 323 MET   A SD  1 
ATOM   2118 C  CE  . MET   A 1 274 ? 151.002 139.718 196.780 1.00 126.28 ? 323 MET   A CE  1 
ATOM   2119 N  N   . GLY   A 1 275 ? 153.902 143.922 195.559 1.00 120.29 ? 324 GLY   A N   1 
ATOM   2120 C  CA  . GLY   A 1 275 ? 155.161 144.449 196.055 1.00 123.54 ? 324 GLY   A CA  1 
ATOM   2121 C  C   . GLY   A 1 275 ? 155.235 145.958 195.956 1.00 126.93 ? 324 GLY   A C   1 
ATOM   2122 O  O   . GLY   A 1 275 ? 155.654 146.636 196.896 1.00 122.42 ? 324 GLY   A O   1 
ATOM   2123 N  N   . PHE   A 1 276 ? 154.811 146.506 194.818 1.00 136.78 ? 325 PHE   A N   1 
ATOM   2124 C  CA  . PHE   A 1 276 ? 154.841 147.958 194.659 1.00 132.31 ? 325 PHE   A CA  1 
ATOM   2125 C  C   . PHE   A 1 276 ? 153.818 148.642 195.558 1.00 129.90 ? 325 PHE   A C   1 
ATOM   2126 O  O   . PHE   A 1 276 ? 154.091 149.715 196.111 1.00 132.84 ? 325 PHE   A O   1 
ATOM   2127 C  CB  . PHE   A 1 276 ? 154.626 148.330 193.196 1.00 129.27 ? 325 PHE   A CB  1 
ATOM   2128 C  CG  . PHE   A 1 276 ? 155.847 148.142 192.353 1.00 131.01 ? 325 PHE   A CG  1 
ATOM   2129 C  CD1 . PHE   A 1 276 ? 157.028 148.780 192.686 1.00 130.55 ? 325 PHE   A CD1 1 
ATOM   2130 C  CD2 . PHE   A 1 276 ? 155.824 147.319 191.243 1.00 131.80 ? 325 PHE   A CD2 1 
ATOM   2131 C  CE1 . PHE   A 1 276 ? 158.159 148.609 191.925 1.00 134.41 ? 325 PHE   A CE1 1 
ATOM   2132 C  CE2 . PHE   A 1 276 ? 156.955 147.144 190.478 1.00 130.09 ? 325 PHE   A CE2 1 
ATOM   2133 C  CZ  . PHE   A 1 276 ? 158.124 147.789 190.822 1.00 134.31 ? 325 PHE   A CZ  1 
ATOM   2134 N  N   . PHE   A 1 277 ? 152.639 148.039 195.725 1.00 123.82 ? 326 PHE   A N   1 
ATOM   2135 C  CA  . PHE   A 1 277 ? 151.649 148.610 196.632 1.00 123.01 ? 326 PHE   A CA  1 
ATOM   2136 C  C   . PHE   A 1 277 ? 152.163 148.626 198.066 1.00 127.90 ? 326 PHE   A C   1 
ATOM   2137 O  O   . PHE   A 1 277 ? 151.994 149.619 198.783 1.00 132.21 ? 326 PHE   A O   1 
ATOM   2138 C  CB  . PHE   A 1 277 ? 150.336 147.834 196.536 1.00 115.85 ? 326 PHE   A CB  1 
ATOM   2139 C  CG  . PHE   A 1 277 ? 149.464 148.258 195.390 1.00 118.42 ? 326 PHE   A CG  1 
ATOM   2140 C  CD1 . PHE   A 1 277 ? 149.049 149.571 195.269 1.00 128.10 ? 326 PHE   A CD1 1 
ATOM   2141 C  CD2 . PHE   A 1 277 ? 149.053 147.345 194.438 1.00 119.84 ? 326 PHE   A CD2 1 
ATOM   2142 C  CE1 . PHE   A 1 277 ? 148.247 149.965 194.217 1.00 127.94 ? 326 PHE   A CE1 1 
ATOM   2143 C  CE2 . PHE   A 1 277 ? 148.252 147.733 193.383 1.00 124.12 ? 326 PHE   A CE2 1 
ATOM   2144 C  CZ  . PHE   A 1 277 ? 147.849 149.044 193.274 1.00 123.77 ? 326 PHE   A CZ  1 
ATOM   2145 N  N   . LEU   A 1 278 ? 152.808 147.540 198.497 1.00 132.43 ? 327 LEU   A N   1 
ATOM   2146 C  CA  . LEU   A 1 278 ? 153.361 147.493 199.845 1.00 137.71 ? 327 LEU   A CA  1 
ATOM   2147 C  C   . LEU   A 1 278 ? 154.544 148.439 200.002 1.00 143.22 ? 327 LEU   A C   1 
ATOM   2148 O  O   . LEU   A 1 278 ? 154.769 148.970 201.095 1.00 143.86 ? 327 LEU   A O   1 
ATOM   2149 C  CB  . LEU   A 1 278 ? 153.771 146.063 200.190 1.00 133.65 ? 327 LEU   A CB  1 
ATOM   2150 C  CG  . LEU   A 1 278 ? 152.675 145.201 200.816 1.00 132.99 ? 327 LEU   A CG  1 
ATOM   2151 C  CD1 . LEU   A 1 278 ? 153.158 143.775 201.013 1.00 135.28 ? 327 LEU   A CD1 1 
ATOM   2152 C  CD2 . LEU   A 1 278 ? 152.211 145.802 202.130 1.00 132.38 ? 327 LEU   A CD2 1 
ATOM   2153 N  N   . ALA   A 1 279 ? 155.320 148.650 198.937 1.00 140.69 ? 328 ALA   A N   1 
ATOM   2154 C  CA  . ALA   A 1 279 ? 156.388 149.641 198.992 1.00 135.03 ? 328 ALA   A CA  1 
ATOM   2155 C  C   . ALA   A 1 279 ? 155.825 151.044 199.163 1.00 135.80 ? 328 ALA   A C   1 
ATOM   2156 O  O   . ALA   A 1 279 ? 156.354 151.841 199.947 1.00 140.38 ? 328 ALA   A O   1 
ATOM   2157 C  CB  . ALA   A 1 279 ? 157.245 149.561 197.733 1.00 136.57 ? 328 ALA   A CB  1 
ATOM   2158 N  N   . ARG   A 1 280 ? 154.757 151.366 198.430 1.00 134.85 ? 329 ARG   A N   1 
ATOM   2159 C  CA  . ARG   A 1 280 ? 154.130 152.675 198.584 1.00 136.12 ? 329 ARG   A CA  1 
ATOM   2160 C  C   . ARG   A 1 280 ? 153.527 152.834 199.974 1.00 138.32 ? 329 ARG   A C   1 
ATOM   2161 O  O   . ARG   A 1 280 ? 153.603 153.914 200.572 1.00 137.35 ? 329 ARG   A O   1 
ATOM   2162 C  CB  . ARG   A 1 280 ? 153.067 152.883 197.508 1.00 135.88 ? 329 ARG   A CB  1 
ATOM   2163 C  CG  . ARG   A 1 280 ? 152.858 154.340 197.135 1.00 133.10 ? 329 ARG   A CG  1 
ATOM   2164 C  CD  . ARG   A 1 280 ? 151.655 154.515 196.228 1.00 135.47 ? 329 ARG   A CD  1 
ATOM   2165 N  NE  . ARG   A 1 280 ? 150.493 153.783 196.713 1.00 134.54 ? 329 ARG   A NE  1 
ATOM   2166 C  CZ  . ARG   A 1 280 ? 149.594 153.203 195.930 1.00 136.85 ? 329 ARG   A CZ  1 
ATOM   2167 N  NH1 . ARG   A 1 280 ? 149.694 153.249 194.612 1.00 136.55 ? 329 ARG   A NH1 1 
ATOM   2168 N  NH2 . ARG   A 1 280 ? 148.569 152.562 196.484 1.00 137.28 ? 329 ARG   A NH2 1 
ATOM   2169 N  N   . ASP   A 1 281 ? 152.922 151.771 200.504 1.00 149.42 ? 330 ASP   A N   1 
ATOM   2170 C  CA  . ASP   A 1 281 ? 152.355 151.786 201.851 1.00 149.52 ? 330 ASP   A CA  1 
ATOM   2171 C  C   . ASP   A 1 281 ? 153.376 151.174 202.806 1.00 146.82 ? 330 ASP   A C   1 
ATOM   2172 O  O   . ASP   A 1 281 ? 153.328 149.991 203.149 1.00 146.82 ? 330 ASP   A O   1 
ATOM   2173 C  CB  . ASP   A 1 281 ? 151.025 151.042 201.882 1.00 148.54 ? 330 ASP   A CB  1 
ATOM   2174 C  CG  . ASP   A 1 281 ? 149.984 151.669 200.977 1.00 148.63 ? 330 ASP   A CG  1 
ATOM   2175 O  OD1 . ASP   A 1 281 ? 150.228 151.754 199.755 1.00 148.14 ? 330 ASP   A OD1 1 
ATOM   2176 O  OD2 . ASP   A 1 281 ? 148.919 152.076 201.487 1.00 146.04 ? 330 ASP   A OD2 1 
ATOM   2177 N  N   . LYS   A 1 282 ? 154.325 152.010 203.236 1.00 148.27 ? 331 LYS   A N   1 
ATOM   2178 C  CA  . LYS   A 1 282 ? 155.379 151.538 204.127 1.00 149.08 ? 331 LYS   A CA  1 
ATOM   2179 C  C   . LYS   A 1 282 ? 154.818 151.119 205.479 1.00 151.42 ? 331 LYS   A C   1 
ATOM   2180 O  O   . LYS   A 1 282 ? 155.297 150.152 206.082 1.00 150.76 ? 331 LYS   A O   1 
ATOM   2181 C  CB  . LYS   A 1 282 ? 156.448 152.616 204.296 1.00 149.63 ? 331 LYS   A CB  1 
ATOM   2182 C  CG  . LYS   A 1 282 ? 157.647 152.441 203.378 1.00 148.27 ? 331 LYS   A CG  1 
ATOM   2183 C  CD  . LYS   A 1 282 ? 158.498 151.251 203.794 1.00 148.84 ? 331 LYS   A CD  1 
ATOM   2184 C  CE  . LYS   A 1 282 ? 158.828 151.293 205.278 1.00 151.83 ? 331 LYS   A CE  1 
ATOM   2185 N  NZ  . LYS   A 1 282 ? 159.646 150.123 205.698 1.00 152.94 ? 331 LYS   A NZ  1 
ATOM   2186 N  N   . THR   A 1 283 ? 153.809 151.836 205.978 1.00 152.03 ? 332 THR   A N   1 
ATOM   2187 C  CA  . THR   A 1 283 ? 153.173 151.435 207.229 1.00 150.20 ? 332 THR   A CA  1 
ATOM   2188 C  C   . THR   A 1 283 ? 152.507 150.072 207.092 1.00 149.77 ? 332 THR   A C   1 
ATOM   2189 O  O   . THR   A 1 283 ? 152.587 149.238 208.002 1.00 150.23 ? 332 THR   A O   1 
ATOM   2190 C  CB  . THR   A 1 283 ? 152.153 152.487 207.664 1.00 149.45 ? 332 THR   A CB  1 
ATOM   2191 O  OG1 . THR   A 1 283 ? 150.881 152.195 207.071 1.00 153.30 ? 332 THR   A OG1 1 
ATOM   2192 C  CG2 . THR   A 1 283 ? 152.602 153.874 207.230 1.00 150.20 ? 332 THR   A CG2 1 
ATOM   2193 N  N   . LEU   A 1 284 ? 151.845 149.826 205.960 1.00 138.97 ? 333 LEU   A N   1 
ATOM   2194 C  CA  . LEU   A 1 284 ? 151.229 148.524 205.730 1.00 140.56 ? 333 LEU   A CA  1 
ATOM   2195 C  C   . LEU   A 1 284 ? 152.281 147.428 205.630 1.00 140.76 ? 333 LEU   A C   1 
ATOM   2196 O  O   . LEU   A 1 284 ? 152.077 146.313 206.122 1.00 138.98 ? 333 LEU   A O   1 
ATOM   2197 C  CB  . LEU   A 1 284 ? 150.376 148.567 204.465 1.00 140.94 ? 333 LEU   A CB  1 
ATOM   2198 C  CG  . LEU   A 1 284 ? 148.940 149.043 204.675 1.00 140.59 ? 333 LEU   A CG  1 
ATOM   2199 C  CD1 . LEU   A 1 284 ? 148.267 149.271 203.340 1.00 140.61 ? 333 LEU   A CD1 1 
ATOM   2200 C  CD2 . LEU   A 1 284 ? 148.162 148.038 205.508 1.00 138.73 ? 333 LEU   A CD2 1 
ATOM   2201 N  N   . GLN   A 1 285 ? 153.410 147.722 204.983 1.00 143.67 ? 334 GLN   A N   1 
ATOM   2202 C  CA  . GLN   A 1 285 ? 154.494 146.746 204.918 1.00 144.46 ? 334 GLN   A CA  1 
ATOM   2203 C  C   . GLN   A 1 285 ? 155.041 146.439 206.307 1.00 142.09 ? 334 GLN   A C   1 
ATOM   2204 O  O   . GLN   A 1 285 ? 155.338 145.281 206.628 1.00 144.19 ? 334 GLN   A O   1 
ATOM   2205 C  CB  . GLN   A 1 285 ? 155.607 147.253 204.003 1.00 143.37 ? 334 GLN   A CB  1 
ATOM   2206 C  CG  . GLN   A 1 285 ? 156.703 146.236 203.750 1.00 133.57 ? 334 GLN   A CG  1 
ATOM   2207 C  CD  . GLN   A 1 285 ? 157.602 146.630 202.601 1.00 137.99 ? 334 GLN   A CD  1 
ATOM   2208 O  OE1 . GLN   A 1 285 ? 158.627 145.995 202.356 1.00 144.67 ? 334 GLN   A OE1 1 
ATOM   2209 N  NE2 . GLN   A 1 285 ? 157.223 147.681 201.885 1.00 136.85 ? 334 GLN   A NE2 1 
ATOM   2210 N  N   . LYS   A 1 286 ? 155.186 147.469 207.142 1.00 154.19 ? 335 LYS   A N   1 
ATOM   2211 C  CA  . LYS   A 1 286 ? 155.635 147.256 208.514 1.00 155.83 ? 335 LYS   A CA  1 
ATOM   2212 C  C   . LYS   A 1 286 ? 154.638 146.409 209.291 1.00 159.22 ? 335 LYS   A C   1 
ATOM   2213 O  O   . LYS   A 1 286 ? 155.031 145.531 210.067 1.00 160.41 ? 335 LYS   A O   1 
ATOM   2214 C  CB  . LYS   A 1 286 ? 155.854 148.599 209.208 1.00 151.63 ? 335 LYS   A CB  1 
ATOM   2215 C  CG  . LYS   A 1 286 ? 156.636 148.505 210.506 1.00 153.02 ? 335 LYS   A CG  1 
ATOM   2216 C  CD  . LYS   A 1 286 ? 158.054 149.022 210.336 1.00 157.14 ? 335 LYS   A CD  1 
ATOM   2217 C  CE  . LYS   A 1 286 ? 158.792 149.054 211.664 1.00 158.58 ? 335 LYS   A CE  1 
ATOM   2218 N  NZ  . LYS   A 1 286 ? 159.849 150.102 211.686 1.00 158.42 ? 335 LYS   A NZ  1 
ATOM   2219 N  N   . LYS   A 1 287 ? 153.341 146.660 209.099 1.00 149.06 ? 336 LYS   A N   1 
ATOM   2220 C  CA  . LYS   A 1 287 ? 152.323 145.848 209.759 1.00 145.80 ? 336 LYS   A CA  1 
ATOM   2221 C  C   . LYS   A 1 287 ? 152.390 144.398 209.295 1.00 142.50 ? 336 LYS   A C   1 
ATOM   2222 O  O   . LYS   A 1 287 ? 152.252 143.471 210.103 1.00 145.85 ? 336 LYS   A O   1 
ATOM   2223 C  CB  . LYS   A 1 287 ? 150.934 146.429 209.496 1.00 146.36 ? 336 LYS   A CB  1 
ATOM   2224 C  CG  . LYS   A 1 287 ? 150.673 147.759 210.182 1.00 146.84 ? 336 LYS   A CG  1 
ATOM   2225 C  CD  . LYS   A 1 287 ? 149.250 147.837 210.709 1.00 145.22 ? 336 LYS   A CD  1 
ATOM   2226 C  CE  . LYS   A 1 287 ? 148.249 147.983 209.574 1.00 146.73 ? 336 LYS   A CE  1 
ATOM   2227 N  NZ  . LYS   A 1 287 ? 148.533 149.177 208.734 1.00 145.52 ? 336 LYS   A NZ  1 
ATOM   2228 N  N   . CYS   A 1 288 ? 152.595 144.183 207.994 1.00 140.19 ? 337 CYS   A N   1 
ATOM   2229 C  CA  . CYS   A 1 288 ? 152.708 142.824 207.476 1.00 146.50 ? 337 CYS   A CA  1 
ATOM   2230 C  C   . CYS   A 1 288 ? 153.919 142.109 208.060 1.00 148.27 ? 337 CYS   A C   1 
ATOM   2231 O  O   . CYS   A 1 288 ? 153.835 140.934 208.438 1.00 147.09 ? 337 CYS   A O   1 
ATOM   2232 C  CB  . CYS   A 1 288 ? 152.781 142.848 205.950 1.00 147.34 ? 337 CYS   A CB  1 
ATOM   2233 S  SG  . CYS   A 1 288 ? 151.240 143.320 205.136 1.00 149.71 ? 337 CYS   A SG  1 
ATOM   2234 N  N   . TYR   A 1 289 ? 155.059 142.799 208.144 1.00 147.16 ? 338 TYR   A N   1 
ATOM   2235 C  CA  . TYR   A 1 289 ? 156.236 142.178 208.743 1.00 143.04 ? 338 TYR   A CA  1 
ATOM   2236 C  C   . TYR   A 1 289 ? 156.019 141.901 210.225 1.00 148.75 ? 338 TYR   A C   1 
ATOM   2237 O  O   . TYR   A 1 289 ? 156.486 140.881 210.745 1.00 153.66 ? 338 TYR   A O   1 
ATOM   2238 C  CB  . TYR   A 1 289 ? 157.473 143.049 208.542 1.00 142.16 ? 338 TYR   A CB  1 
ATOM   2239 C  CG  . TYR   A 1 289 ? 158.728 142.395 209.071 1.00 144.23 ? 338 TYR   A CG  1 
ATOM   2240 C  CD1 . TYR   A 1 289 ? 159.409 141.452 208.318 1.00 143.95 ? 338 TYR   A CD1 1 
ATOM   2241 C  CD2 . TYR   A 1 289 ? 159.222 142.706 210.331 1.00 148.48 ? 338 TYR   A CD2 1 
ATOM   2242 C  CE1 . TYR   A 1 289 ? 160.551 140.843 208.796 1.00 146.18 ? 338 TYR   A CE1 1 
ATOM   2243 C  CE2 . TYR   A 1 289 ? 160.364 142.101 210.819 1.00 150.26 ? 338 TYR   A CE2 1 
ATOM   2244 C  CZ  . TYR   A 1 289 ? 161.024 141.170 210.047 1.00 150.41 ? 338 TYR   A CZ  1 
ATOM   2245 O  OH  . TYR   A 1 289 ? 162.163 140.565 210.525 1.00 152.92 ? 338 TYR   A OH  1 
ATOM   2246 N  N   . LEU   A 1 290 ? 155.324 142.799 210.924 1.00 146.98 ? 339 LEU   A N   1 
ATOM   2247 C  CA  . LEU   A 1 290 ? 155.001 142.548 212.323 1.00 145.85 ? 339 LEU   A CA  1 
ATOM   2248 C  C   . LEU   A 1 290 ? 154.131 141.308 212.464 1.00 145.79 ? 339 LEU   A C   1 
ATOM   2249 O  O   . LEU   A 1 290 ? 154.314 140.515 213.394 1.00 143.88 ? 339 LEU   A O   1 
ATOM   2250 C  CB  . LEU   A 1 290 ? 154.308 143.764 212.934 1.00 143.19 ? 339 LEU   A CB  1 
ATOM   2251 C  CG  . LEU   A 1 290 ? 154.370 143.856 214.459 1.00 146.84 ? 339 LEU   A CG  1 
ATOM   2252 C  CD1 . LEU   A 1 290 ? 155.760 143.504 214.964 1.00 145.85 ? 339 LEU   A CD1 1 
ATOM   2253 C  CD2 . LEU   A 1 290 ? 153.962 145.244 214.928 1.00 150.42 ? 339 LEU   A CD2 1 
ATOM   2254 N  N   . GLU   A 1 291 ? 153.175 141.129 211.551 1.00 148.96 ? 340 GLU   A N   1 
ATOM   2255 C  CA  . GLU   A 1 291 ? 152.378 139.907 211.544 1.00 148.51 ? 340 GLU   A CA  1 
ATOM   2256 C  C   . GLU   A 1 291 ? 153.255 138.682 211.327 1.00 146.27 ? 340 GLU   A C   1 
ATOM   2257 O  O   . GLU   A 1 291 ? 153.116 137.671 212.023 1.00 145.01 ? 340 GLU   A O   1 
ATOM   2258 C  CB  . GLU   A 1 291 ? 151.301 139.983 210.465 1.00 148.65 ? 340 GLU   A CB  1 
ATOM   2259 C  CG  . GLU   A 1 291 ? 150.169 139.001 210.679 1.00 148.76 ? 340 GLU   A CG  1 
ATOM   2260 C  CD  . GLU   A 1 291 ? 149.131 139.070 209.587 1.00 148.09 ? 340 GLU   A CD  1 
ATOM   2261 O  OE1 . GLU   A 1 291 ? 149.512 139.007 208.399 1.00 145.41 ? 340 GLU   A OE1 1 
ATOM   2262 O  OE2 . GLU   A 1 291 ? 147.933 139.184 209.917 1.00 147.97 ? 340 GLU   A OE2 1 
ATOM   2263 N  N   . GLN   A 1 292 ? 154.170 138.757 210.357 1.00 146.18 ? 341 GLN   A N   1 
ATOM   2264 C  CA  . GLN   A 1 292 ? 155.085 137.642 210.125 1.00 148.60 ? 341 GLN   A CA  1 
ATOM   2265 C  C   . GLN   A 1 292 ? 155.910 137.337 211.366 1.00 151.31 ? 341 GLN   A C   1 
ATOM   2266 O  O   . GLN   A 1 292 ? 156.258 136.178 211.616 1.00 152.75 ? 341 GLN   A O   1 
ATOM   2267 C  CB  . GLN   A 1 292 ? 156.009 137.945 208.943 1.00 148.29 ? 341 GLN   A CB  1 
ATOM   2268 C  CG  . GLN   A 1 292 ? 155.301 138.310 207.648 1.00 150.85 ? 341 GLN   A CG  1 
ATOM   2269 C  CD  . GLN   A 1 292 ? 154.623 137.132 206.978 1.00 150.66 ? 341 GLN   A CD  1 
ATOM   2270 O  OE1 . GLN   A 1 292 ? 154.504 136.051 207.553 1.00 151.81 ? 341 GLN   A OE1 1 
ATOM   2271 N  NE2 . GLN   A 1 292 ? 154.166 137.341 205.751 1.00 149.55 ? 341 GLN   A NE2 1 
ATOM   2272 N  N   . LYS   A 1 293 ? 156.231 138.365 212.149 1.00 157.65 ? 342 LYS   A N   1 
ATOM   2273 C  CA  . LYS   A 1 293 ? 157.019 138.162 213.359 1.00 156.19 ? 342 LYS   A CA  1 
ATOM   2274 C  C   . LYS   A 1 293 ? 156.183 137.558 214.481 1.00 159.75 ? 342 LYS   A C   1 
ATOM   2275 O  O   . LYS   A 1 293 ? 156.689 136.753 215.271 1.00 160.03 ? 342 LYS   A O   1 
ATOM   2276 C  CB  . LYS   A 1 293 ? 157.634 139.487 213.807 1.00 157.32 ? 342 LYS   A CB  1 
ATOM   2277 C  CG  . LYS   A 1 293 ? 158.928 139.346 214.587 1.00 160.32 ? 342 LYS   A CG  1 
ATOM   2278 C  CD  . LYS   A 1 293 ? 159.680 140.667 214.635 1.00 158.56 ? 342 LYS   A CD  1 
ATOM   2279 C  CE  . LYS   A 1 293 ? 161.172 140.466 214.428 1.00 157.65 ? 342 LYS   A CE  1 
ATOM   2280 N  NZ  . LYS   A 1 293 ? 161.808 141.662 213.813 1.00 157.52 ? 342 LYS   A NZ  1 
ATOM   2281 N  N   . THR   A 1 294 ? 154.907 137.934 214.577 1.00 165.61 ? 343 THR   A N   1 
ATOM   2282 C  CA  . THR   A 1 294 ? 154.112 137.591 215.754 1.00 165.47 ? 343 THR   A CA  1 
ATOM   2283 C  C   . THR   A 1 294 ? 153.269 136.329 215.585 1.00 164.00 ? 343 THR   A C   1 
ATOM   2284 O  O   . THR   A 1 294 ? 153.175 135.532 216.522 1.00 163.29 ? 343 THR   A O   1 
ATOM   2285 C  CB  . THR   A 1 294 ? 153.212 138.771 216.161 1.00 166.47 ? 343 THR   A CB  1 
ATOM   2286 O  OG1 . THR   A 1 294 ? 152.561 138.468 217.401 1.00 168.55 ? 343 THR   A OG1 1 
ATOM   2287 C  CG2 . THR   A 1 294 ? 152.154 139.067 215.105 1.00 164.95 ? 343 THR   A CG2 1 
ATOM   2288 N  N   . VAL   A 1 295 ? 152.652 136.116 214.424 1.00 160.00 ? 344 VAL   A N   1 
ATOM   2289 C  CA  . VAL   A 1 295 ? 151.715 135.005 214.301 1.00 164.02 ? 344 VAL   A CA  1 
ATOM   2290 C  C   . VAL   A 1 295 ? 152.393 133.737 213.785 1.00 162.51 ? 344 VAL   A C   1 
ATOM   2291 O  O   . VAL   A 1 295 ? 151.998 132.630 214.163 1.00 162.27 ? 344 VAL   A O   1 
ATOM   2292 C  CB  . VAL   A 1 295 ? 150.514 135.397 213.418 1.00 165.39 ? 344 VAL   A CB  1 
ATOM   2293 C  CG1 . VAL   A 1 295 ? 150.906 135.495 211.950 1.00 162.87 ? 344 VAL   A CG1 1 
ATOM   2294 C  CG2 . VAL   A 1 295 ? 149.366 134.420 213.615 1.00 164.26 ? 344 VAL   A CG2 1 
ATOM   2295 N  N   . CYS   A 1 296 ? 153.409 133.868 212.931 1.00 156.29 ? 345 CYS   A N   1 
ATOM   2296 C  CA  . CYS   A 1 296 ? 154.147 132.693 212.486 1.00 158.47 ? 345 CYS   A CA  1 
ATOM   2297 C  C   . CYS   A 1 296 ? 155.111 132.207 213.560 1.00 161.45 ? 345 CYS   A C   1 
ATOM   2298 O  O   . CYS   A 1 296 ? 155.326 130.998 213.706 1.00 164.02 ? 345 CYS   A O   1 
ATOM   2299 C  CB  . CYS   A 1 296 ? 154.904 133.006 211.197 1.00 158.60 ? 345 CYS   A CB  1 
ATOM   2300 S  SG  . CYS   A 1 296 ? 153.992 134.031 210.027 1.00 160.64 ? 345 CYS   A SG  1 
ATOM   2301 N  N   . GLY   A 1 297 ? 155.694 133.132 214.317 1.00 166.01 ? 346 GLY   A N   1 
ATOM   2302 C  CA  . GLY   A 1 297 ? 156.672 132.796 215.331 1.00 165.15 ? 346 GLY   A CA  1 
ATOM   2303 C  C   . GLY   A 1 297 ? 157.732 133.868 215.464 1.00 165.65 ? 346 GLY   A C   1 
ATOM   2304 O  O   . GLY   A 1 297 ? 158.163 134.448 214.462 1.00 167.84 ? 346 GLY   A O   1 
ATOM   2305 N  N   . GLU   A 1 298 ? 158.158 134.147 216.698 1.00 177.42 ? 347 GLU   A N   1 
ATOM   2306 C  CA  . GLU   A 1 298 ? 159.159 135.187 216.916 1.00 180.32 ? 347 GLU   A CA  1 
ATOM   2307 C  C   . GLU   A 1 298 ? 160.493 134.817 216.281 1.00 181.51 ? 347 GLU   A C   1 
ATOM   2308 O  O   . GLU   A 1 298 ? 161.202 135.686 215.761 1.00 179.75 ? 347 GLU   A O   1 
ATOM   2309 C  CB  . GLU   A 1 298 ? 159.326 135.449 218.413 1.00 180.03 ? 347 GLU   A CB  1 
ATOM   2310 C  CG  . GLU   A 1 298 ? 158.267 136.369 218.997 1.00 179.46 ? 347 GLU   A CG  1 
ATOM   2311 C  CD  . GLU   A 1 298 ? 158.149 137.678 218.240 1.00 180.40 ? 347 GLU   A CD  1 
ATOM   2312 O  OE1 . GLU   A 1 298 ? 159.196 138.277 217.916 1.00 179.03 ? 347 GLU   A OE1 1 
ATOM   2313 O  OE2 . GLU   A 1 298 ? 157.009 138.108 217.967 1.00 179.23 ? 347 GLU   A OE2 1 
ATOM   2314 N  N   . ASN   A 1 299 ? 160.851 133.535 216.311 1.00 174.39 ? 348 ASN   A N   1 
ATOM   2315 C  CA  . ASN   A 1 299 ? 162.077 133.059 215.684 1.00 171.30 ? 348 ASN   A CA  1 
ATOM   2316 C  C   . ASN   A 1 299 ? 161.957 132.936 214.171 1.00 170.01 ? 348 ASN   A C   1 
ATOM   2317 O  O   . ASN   A 1 299 ? 162.951 132.605 213.515 1.00 167.68 ? 348 ASN   A O   1 
ATOM   2318 C  CB  . ASN   A 1 299 ? 162.478 131.706 216.276 1.00 169.57 ? 348 ASN   A CB  1 
ATOM   2319 C  CG  . ASN   A 1 299 ? 161.335 130.712 216.283 1.00 170.96 ? 348 ASN   A CG  1 
ATOM   2320 O  OD1 . ASN   A 1 299 ? 160.311 130.930 216.930 1.00 169.61 ? 348 ASN   A OD1 1 
ATOM   2321 N  ND2 . ASN   A 1 299 ? 161.502 129.613 215.556 1.00 172.12 ? 348 ASN   A ND2 1 
ATOM   2322 N  N   . LEU   A 1 300 ? 160.771 133.186 213.611 1.00 162.85 ? 349 LEU   A N   1 
ATOM   2323 C  CA  . LEU   A 1 300 ? 160.494 133.090 212.182 1.00 162.03 ? 349 LEU   A CA  1 
ATOM   2324 C  C   . LEU   A 1 300 ? 160.807 131.690 211.666 1.00 161.77 ? 349 LEU   A C   1 
ATOM   2325 O  O   . LEU   A 1 300 ? 161.771 131.506 210.913 1.00 162.31 ? 349 LEU   A O   1 
ATOM   2326 C  CB  . LEU   A 1 300 ? 161.289 134.141 211.404 1.00 161.03 ? 349 LEU   A CB  1 
ATOM   2327 C  CG  . LEU   A 1 300 ? 161.104 135.587 211.870 1.00 159.20 ? 349 LEU   A CG  1 
ATOM   2328 C  CD1 . LEU   A 1 300 ? 162.051 136.521 211.131 1.00 158.74 ? 349 LEU   A CD1 1 
ATOM   2329 C  CD2 . LEU   A 1 300 ? 159.660 136.027 211.688 1.00 157.72 ? 349 LEU   A CD2 1 
ATOM   2330 N  N   . PRO   A 1 301 ? 160.026 130.685 212.048 1.00 162.44 ? 350 PRO   A N   1 
ATOM   2331 C  CA  . PRO   A 1 301 ? 160.265 129.329 211.556 1.00 164.22 ? 350 PRO   A CA  1 
ATOM   2332 C  C   . PRO   A 1 301 ? 159.771 129.180 210.129 1.00 163.17 ? 350 PRO   A C   1 
ATOM   2333 O  O   . PRO   A 1 301 ? 159.020 130.034 209.634 1.00 158.17 ? 350 PRO   A O   1 
ATOM   2334 C  CB  . PRO   A 1 301 ? 159.450 128.461 212.524 1.00 164.63 ? 350 PRO   A CB  1 
ATOM   2335 C  CG  . PRO   A 1 301 ? 158.312 129.336 212.918 1.00 161.37 ? 350 PRO   A CG  1 
ATOM   2336 C  CD  . PRO   A 1 301 ? 158.826 130.758 212.903 1.00 160.33 ? 350 PRO   A CD  1 
ATOM   2337 N  N   . PRO   A 1 302 ? 160.180 128.121 209.429 1.00 155.42 ? 351 PRO   A N   1 
ATOM   2338 C  CA  . PRO   A 1 302 ? 159.671 127.900 208.070 1.00 152.36 ? 351 PRO   A CA  1 
ATOM   2339 C  C   . PRO   A 1 302 ? 158.155 127.762 208.061 1.00 151.84 ? 351 PRO   A C   1 
ATOM   2340 O  O   . PRO   A 1 302 ? 157.559 127.184 208.972 1.00 148.98 ? 351 PRO   A O   1 
ATOM   2341 C  CB  . PRO   A 1 302 ? 160.360 126.601 207.640 1.00 149.15 ? 351 PRO   A CB  1 
ATOM   2342 C  CG  . PRO   A 1 302 ? 161.590 126.533 208.478 1.00 150.36 ? 351 PRO   A CG  1 
ATOM   2343 C  CD  . PRO   A 1 302 ? 161.216 127.141 209.796 1.00 151.63 ? 351 PRO   A CD  1 
ATOM   2344 N  N   . LEU   A 1 303 ? 157.536 128.303 207.016 1.00 131.77 ? 352 LEU   A N   1 
ATOM   2345 C  CA  . LEU   A 1 303 ? 156.085 128.318 206.929 1.00 131.74 ? 352 LEU   A CA  1 
ATOM   2346 C  C   . LEU   A 1 303 ? 155.535 126.921 206.661 1.00 130.94 ? 352 LEU   A C   1 
ATOM   2347 O  O   . LEU   A 1 303 ? 156.241 126.013 206.217 1.00 132.16 ? 352 LEU   A O   1 
ATOM   2348 C  CB  . LEU   A 1 303 ? 155.614 129.270 205.829 1.00 130.14 ? 352 LEU   A CB  1 
ATOM   2349 C  CG  . LEU   A 1 303 ? 155.405 130.738 206.202 1.00 129.86 ? 352 LEU   A CG  1 
ATOM   2350 C  CD1 . LEU   A 1 303 ? 156.728 131.471 206.305 1.00 126.77 ? 352 LEU   A CD1 1 
ATOM   2351 C  CD2 . LEU   A 1 303 ? 154.491 131.416 205.200 1.00 129.45 ? 352 LEU   A CD2 1 
ATOM   2352 N  N   . THR   A 1 304 ? 154.245 126.763 206.947 1.00 141.77 ? 353 THR   A N   1 
ATOM   2353 C  CA  . THR   A 1 304 ? 153.500 125.561 206.613 1.00 140.56 ? 353 THR   A CA  1 
ATOM   2354 C  C   . THR   A 1 304 ? 152.068 125.966 206.298 1.00 137.88 ? 353 THR   A C   1 
ATOM   2355 O  O   . THR   A 1 304 ? 151.633 127.079 206.607 1.00 144.49 ? 353 THR   A O   1 
ATOM   2356 C  CB  . THR   A 1 304 ? 153.542 124.525 207.744 1.00 141.14 ? 353 THR   A CB  1 
ATOM   2357 O  OG1 . THR   A 1 304 ? 153.099 123.256 207.247 1.00 139.72 ? 353 THR   A OG1 1 
ATOM   2358 C  CG2 . THR   A 1 304 ? 152.639 124.948 208.887 1.00 141.65 ? 353 THR   A CG2 1 
ATOM   2359 N  N   . TYR   A 1 305 ? 151.332 125.048 205.667 1.00 132.83 ? 354 TYR   A N   1 
ATOM   2360 C  CA  . TYR   A 1 305 ? 149.960 125.353 205.278 1.00 137.12 ? 354 TYR   A CA  1 
ATOM   2361 C  C   . TYR   A 1 305 ? 149.106 125.731 206.479 1.00 141.14 ? 354 TYR   A C   1 
ATOM   2362 O  O   . TYR   A 1 305 ? 148.188 126.550 206.354 1.00 142.93 ? 354 TYR   A O   1 
ATOM   2363 C  CB  . TYR   A 1 305 ? 149.341 124.167 204.543 1.00 136.20 ? 354 TYR   A CB  1 
ATOM   2364 C  CG  . TYR   A 1 305 ? 148.133 124.546 203.723 1.00 137.79 ? 354 TYR   A CG  1 
ATOM   2365 C  CD1 . TYR   A 1 305 ? 148.258 125.362 202.609 1.00 136.70 ? 354 TYR   A CD1 1 
ATOM   2366 C  CD2 . TYR   A 1 305 ? 146.867 124.102 204.071 1.00 136.88 ? 354 TYR   A CD2 1 
ATOM   2367 C  CE1 . TYR   A 1 305 ? 147.158 125.717 201.859 1.00 138.21 ? 354 TYR   A CE1 1 
ATOM   2368 C  CE2 . TYR   A 1 305 ? 145.760 124.454 203.328 1.00 139.89 ? 354 TYR   A CE2 1 
ATOM   2369 C  CZ  . TYR   A 1 305 ? 145.911 125.261 202.222 1.00 141.84 ? 354 TYR   A CZ  1 
ATOM   2370 O  OH  . TYR   A 1 305 ? 144.811 125.614 201.475 1.00 143.33 ? 354 TYR   A OH  1 
ATOM   2371 N  N   . ASP   A 1 306 ? 149.388 125.150 207.647 1.00 143.57 ? 355 ASP   A N   1 
ATOM   2372 C  CA  . ASP   A 1 306 ? 148.654 125.523 208.851 1.00 146.03 ? 355 ASP   A CA  1 
ATOM   2373 C  C   . ASP   A 1 306 ? 148.887 126.986 209.206 1.00 147.35 ? 355 ASP   A C   1 
ATOM   2374 O  O   . ASP   A 1 306 ? 147.947 127.701 209.571 1.00 148.89 ? 355 ASP   A O   1 
ATOM   2375 C  CB  . ASP   A 1 306 ? 149.057 124.616 210.011 1.00 145.64 ? 355 ASP   A CB  1 
ATOM   2376 C  CG  . ASP   A 1 306 ? 148.910 123.146 209.677 1.00 149.69 ? 355 ASP   A CG  1 
ATOM   2377 O  OD1 . ASP   A 1 306 ? 148.484 122.834 208.545 1.00 148.76 ? 355 ASP   A OD1 1 
ATOM   2378 O  OD2 . ASP   A 1 306 ? 149.218 122.303 210.545 1.00 151.75 ? 355 ASP   A OD2 1 
ATOM   2379 N  N   . GLN   A 1 307 ? 150.134 127.450 209.103 1.00 143.96 ? 356 GLN   A N   1 
ATOM   2380 C  CA  . GLN   A 1 307 ? 150.428 128.849 209.389 1.00 143.15 ? 356 GLN   A CA  1 
ATOM   2381 C  C   . GLN   A 1 307 ? 149.973 129.779 208.274 1.00 141.38 ? 356 GLN   A C   1 
ATOM   2382 O  O   . GLN   A 1 307 ? 149.848 130.985 208.508 1.00 146.04 ? 356 GLN   A O   1 
ATOM   2383 C  CB  . GLN   A 1 307 ? 151.925 129.040 209.639 1.00 138.41 ? 356 GLN   A CB  1 
ATOM   2384 C  CG  . GLN   A 1 307 ? 152.374 128.640 211.033 1.00 140.11 ? 356 GLN   A CG  1 
ATOM   2385 C  CD  . GLN   A 1 307 ? 153.422 127.550 211.015 1.00 146.00 ? 356 GLN   A CD  1 
ATOM   2386 O  OE1 . GLN   A 1 307 ? 154.262 127.496 210.118 1.00 145.74 ? 356 GLN   A OE1 1 
ATOM   2387 N  NE2 . GLN   A 1 307 ? 153.377 126.669 212.008 1.00 147.97 ? 356 GLN   A NE2 1 
ATOM   2388 N  N   . LEU   A 1 308 ? 149.730 129.252 207.072 1.00 130.37 ? 357 LEU   A N   1 
ATOM   2389 C  CA  . LEU   A 1 308 ? 149.263 130.103 205.981 1.00 130.35 ? 357 LEU   A CA  1 
ATOM   2390 C  C   . LEU   A 1 308 ? 147.924 130.748 206.313 1.00 137.87 ? 357 LEU   A C   1 
ATOM   2391 O  O   . LEU   A 1 308 ? 147.719 131.938 206.049 1.00 144.36 ? 357 LEU   A O   1 
ATOM   2392 C  CB  . LEU   A 1 308 ? 149.161 129.304 204.684 1.00 130.76 ? 357 LEU   A CB  1 
ATOM   2393 C  CG  . LEU   A 1 308 ? 150.317 129.448 203.693 1.00 134.63 ? 357 LEU   A CG  1 
ATOM   2394 C  CD1 . LEU   A 1 308 ? 150.225 130.785 202.988 1.00 130.15 ? 357 LEU   A CD1 1 
ATOM   2395 C  CD2 . LEU   A 1 308 ? 151.659 129.304 204.375 1.00 137.17 ? 357 LEU   A CD2 1 
ATOM   2396 N  N   . LYS   A 1 309 ? 147.001 129.983 206.900 1.00 152.21 ? 358 LYS   A N   1 
ATOM   2397 C  CA  . LYS   A 1 309 ? 145.694 130.530 207.247 1.00 154.27 ? 358 LYS   A CA  1 
ATOM   2398 C  C   . LYS   A 1 309 ? 145.784 131.625 208.301 1.00 152.33 ? 358 LYS   A C   1 
ATOM   2399 O  O   . LYS   A 1 309 ? 144.830 132.394 208.463 1.00 152.14 ? 358 LYS   A O   1 
ATOM   2400 C  CB  . LYS   A 1 309 ? 144.770 129.413 207.735 1.00 153.90 ? 358 LYS   A CB  1 
ATOM   2401 C  CG  . LYS   A 1 309 ? 144.256 128.507 206.628 1.00 155.99 ? 358 LYS   A CG  1 
ATOM   2402 C  CD  . LYS   A 1 309 ? 143.637 129.315 205.499 1.00 155.15 ? 358 LYS   A CD  1 
ATOM   2403 C  CE  . LYS   A 1 309 ? 143.483 128.476 204.242 1.00 154.56 ? 358 LYS   A CE  1 
ATOM   2404 N  NZ  . LYS   A 1 309 ? 144.733 127.734 203.920 1.00 153.81 ? 358 LYS   A NZ  1 
ATOM   2405 N  N   . ASP   A 1 310 ? 146.903 131.716 209.018 1.00 145.92 ? 359 ASP   A N   1 
ATOM   2406 C  CA  . ASP   A 1 310 ? 147.075 132.721 210.058 1.00 143.14 ? 359 ASP   A CA  1 
ATOM   2407 C  C   . ASP   A 1 310 ? 147.490 134.082 209.514 1.00 142.71 ? 359 ASP   A C   1 
ATOM   2408 O  O   . ASP   A 1 310 ? 147.551 135.044 210.287 1.00 145.55 ? 359 ASP   A O   1 
ATOM   2409 C  CB  . ASP   A 1 310 ? 148.112 132.244 211.076 1.00 144.45 ? 359 ASP   A CB  1 
ATOM   2410 C  CG  . ASP   A 1 310 ? 147.687 130.977 211.789 1.00 149.56 ? 359 ASP   A CG  1 
ATOM   2411 O  OD1 . ASP   A 1 310 ? 146.695 130.353 211.356 1.00 150.71 ? 359 ASP   A OD1 1 
ATOM   2412 O  OD2 . ASP   A 1 310 ? 148.346 130.603 212.782 1.00 148.17 ? 359 ASP   A OD2 1 
ATOM   2413 N  N   . LEU   A 1 311 ? 147.778 134.188 208.220 1.00 125.83 ? 360 LEU   A N   1 
ATOM   2414 C  CA  . LEU   A 1 311 ? 148.240 135.443 207.629 1.00 131.88 ? 360 LEU   A CA  1 
ATOM   2415 C  C   . LEU   A 1 311 ? 147.063 136.175 206.986 1.00 135.30 ? 360 LEU   A C   1 
ATOM   2416 O  O   . LEU   A 1 311 ? 146.993 136.375 205.771 1.00 135.28 ? 360 LEU   A O   1 
ATOM   2417 C  CB  . LEU   A 1 311 ? 149.354 135.173 206.622 1.00 128.45 ? 360 LEU   A CB  1 
ATOM   2418 C  CG  . LEU   A 1 311 ? 150.781 135.167 207.172 1.00 129.57 ? 360 LEU   A CG  1 
ATOM   2419 C  CD1 . LEU   A 1 311 ? 150.978 134.038 208.165 1.00 132.03 ? 360 LEU   A CD1 1 
ATOM   2420 C  CD2 . LEU   A 1 311 ? 151.775 135.054 206.040 1.00 129.46 ? 360 LEU   A CD2 1 
ATOM   2421 N  N   . ASN   A 1 312 ? 146.124 136.581 207.843 1.00 141.05 ? 361 ASN   A N   1 
ATOM   2422 C  CA  . ASN   A 1 312 ? 144.921 137.245 207.354 1.00 139.52 ? 361 ASN   A CA  1 
ATOM   2423 C  C   . ASN   A 1 312 ? 145.244 138.594 206.722 1.00 140.57 ? 361 ASN   A C   1 
ATOM   2424 O  O   . ASN   A 1 312 ? 144.648 138.963 205.705 1.00 146.18 ? 361 ASN   A O   1 
ATOM   2425 C  CB  . ASN   A 1 312 ? 143.906 137.400 208.488 1.00 139.89 ? 361 ASN   A CB  1 
ATOM   2426 C  CG  . ASN   A 1 312 ? 144.501 138.034 209.728 1.00 145.71 ? 361 ASN   A CG  1 
ATOM   2427 O  OD1 . ASN   A 1 312 ? 145.186 139.053 209.654 1.00 146.09 ? 361 ASN   A OD1 1 
ATOM   2428 N  ND2 . ASN   A 1 312 ? 144.241 137.430 210.882 1.00 146.20 ? 361 ASN   A ND2 1 
ATOM   2429 N  N   . LEU   A 1 313 ? 146.177 139.349 207.309 1.00 132.46 ? 362 LEU   A N   1 
ATOM   2430 C  CA  . LEU   A 1 313 ? 146.533 140.644 206.735 1.00 137.29 ? 362 LEU   A CA  1 
ATOM   2431 C  C   . LEU   A 1 313 ? 147.185 140.484 205.366 1.00 137.02 ? 362 LEU   A C   1 
ATOM   2432 O  O   . LEU   A 1 313 ? 146.889 141.247 204.439 1.00 138.08 ? 362 LEU   A O   1 
ATOM   2433 C  CB  . LEU   A 1 313 ? 147.453 141.411 207.683 1.00 137.93 ? 362 LEU   A CB  1 
ATOM   2434 C  CG  . LEU   A 1 313 ? 147.972 142.763 207.189 1.00 137.39 ? 362 LEU   A CG  1 
ATOM   2435 C  CD1 . LEU   A 1 313 ? 146.831 143.645 206.709 1.00 133.58 ? 362 LEU   A CD1 1 
ATOM   2436 C  CD2 . LEU   A 1 313 ? 148.764 143.462 208.282 1.00 139.60 ? 362 LEU   A CD2 1 
ATOM   2437 N  N   . LEU   A 1 314 ? 148.075 139.501 205.217 1.00 124.18 ? 363 LEU   A N   1 
ATOM   2438 C  CA  . LEU   A 1 314 ? 148.672 139.256 203.908 1.00 123.64 ? 363 LEU   A CA  1 
ATOM   2439 C  C   . LEU   A 1 314 ? 147.624 138.786 202.909 1.00 125.33 ? 363 LEU   A C   1 
ATOM   2440 O  O   . LEU   A 1 314 ? 147.678 139.145 201.728 1.00 129.86 ? 363 LEU   A O   1 
ATOM   2441 C  CB  . LEU   A 1 314 ? 149.804 138.236 204.025 1.00 119.12 ? 363 LEU   A CB  1 
ATOM   2442 C  CG  . LEU   A 1 314 ? 150.674 138.020 202.783 1.00 114.19 ? 363 LEU   A CG  1 
ATOM   2443 C  CD1 . LEU   A 1 314 ? 150.914 139.321 202.035 1.00 113.92 ? 363 LEU   A CD1 1 
ATOM   2444 C  CD2 . LEU   A 1 314 ? 151.993 137.381 203.169 1.00 121.23 ? 363 LEU   A CD2 1 
ATOM   2445 N  N   . ASP   A 1 315 ? 146.662 137.979 203.365 1.00 128.19 ? 364 ASP   A N   1 
ATOM   2446 C  CA  . ASP   A 1 315 ? 145.571 137.568 202.488 1.00 130.14 ? 364 ASP   A CA  1 
ATOM   2447 C  C   . ASP   A 1 315 ? 144.769 138.772 202.014 1.00 133.52 ? 364 ASP   A C   1 
ATOM   2448 O  O   . ASP   A 1 315 ? 144.403 138.861 200.837 1.00 135.95 ? 364 ASP   A O   1 
ATOM   2449 C  CB  . ASP   A 1 315 ? 144.668 136.570 203.212 1.00 130.82 ? 364 ASP   A CB  1 
ATOM   2450 C  CG  . ASP   A 1 315 ? 143.480 136.148 202.376 1.00 135.20 ? 364 ASP   A CG  1 
ATOM   2451 O  OD1 . ASP   A 1 315 ? 143.623 136.065 201.139 1.00 136.15 ? 364 ASP   A OD1 1 
ATOM   2452 O  OD2 . ASP   A 1 315 ? 142.403 135.901 202.956 1.00 136.65 ? 364 ASP   A OD2 1 
ATOM   2453 N  N   . ARG   A 1 316 ? 144.491 139.711 202.919 1.00 133.22 ? 365 ARG   A N   1 
ATOM   2454 C  CA  . ARG   A 1 316 ? 143.780 140.927 202.537 1.00 132.40 ? 365 ARG   A CA  1 
ATOM   2455 C  C   . ARG   A 1 316 ? 144.597 141.760 201.560 1.00 137.23 ? 365 ARG   A C   1 
ATOM   2456 O  O   . ARG   A 1 316 ? 144.045 142.353 200.626 1.00 141.75 ? 365 ARG   A O   1 
ATOM   2457 C  CB  . ARG   A 1 316 ? 143.435 141.746 203.780 1.00 128.78 ? 365 ARG   A CB  1 
ATOM   2458 C  CG  . ARG   A 1 316 ? 142.478 141.055 204.730 1.00 130.81 ? 365 ARG   A CG  1 
ATOM   2459 C  CD  . ARG   A 1 316 ? 141.682 142.065 205.530 1.00 133.09 ? 365 ARG   A CD  1 
ATOM   2460 N  NE  . ARG   A 1 316 ? 142.545 142.895 206.361 1.00 136.99 ? 365 ARG   A NE  1 
ATOM   2461 C  CZ  . ARG   A 1 316 ? 142.842 142.631 207.625 1.00 138.67 ? 365 ARG   A CZ  1 
ATOM   2462 N  NH1 . ARG   A 1 316 ? 142.365 141.561 208.238 1.00 133.93 ? 365 ARG   A NH1 1 
ATOM   2463 N  NH2 . ARG   A 1 316 ? 143.638 143.462 208.291 1.00 140.09 ? 365 ARG   A NH2 1 
ATOM   2464 N  N   . CYS   A 1 317 ? 145.913 141.832 201.768 1.00 126.67 ? 366 CYS   A N   1 
ATOM   2465 C  CA  . CYS   A 1 317 ? 146.768 142.574 200.845 1.00 122.53 ? 366 CYS   A CA  1 
ATOM   2466 C  C   . CYS   A 1 317 ? 146.742 141.956 199.453 1.00 123.06 ? 366 CYS   A C   1 
ATOM   2467 O  O   . CYS   A 1 317 ? 146.655 142.672 198.449 1.00 125.82 ? 366 CYS   A O   1 
ATOM   2468 C  CB  . CYS   A 1 317 ? 148.197 142.631 201.380 1.00 121.83 ? 366 CYS   A CB  1 
ATOM   2469 S  SG  . CYS   A 1 317 ? 148.398 143.645 202.861 1.00 142.77 ? 366 CYS   A SG  1 
ATOM   2470 N  N   . ILE   A 1 318 ? 146.810 140.625 199.375 1.00 123.51 ? 367 ILE   A N   1 
ATOM   2471 C  CA  . ILE   A 1 318 ? 146.727 139.952 198.081 1.00 121.56 ? 367 ILE   A CA  1 
ATOM   2472 C  C   . ILE   A 1 318 ? 145.365 140.190 197.443 1.00 120.62 ? 367 ILE   A C   1 
ATOM   2473 O  O   . ILE   A 1 318 ? 145.258 140.407 196.229 1.00 126.19 ? 367 ILE   A O   1 
ATOM   2474 C  CB  . ILE   A 1 318 ? 147.022 138.449 198.233 1.00 110.96 ? 367 ILE   A CB  1 
ATOM   2475 C  CG1 . ILE   A 1 318 ? 148.425 138.235 198.792 1.00 113.34 ? 367 ILE   A CG1 1 
ATOM   2476 C  CG2 . ILE   A 1 318 ? 146.889 137.740 196.900 1.00 112.16 ? 367 ILE   A CG2 1 
ATOM   2477 C  CD1 . ILE   A 1 318 ? 148.591 136.924 199.503 1.00 120.40 ? 367 ILE   A CD1 1 
ATOM   2478 N  N   . LYS   A 1 319 ? 144.301 140.146 198.248 1.00 116.36 ? 368 LYS   A N   1 
ATOM   2479 C  CA  . LYS   A 1 319 ? 142.963 140.379 197.718 1.00 115.06 ? 368 LYS   A CA  1 
ATOM   2480 C  C   . LYS   A 1 319 ? 142.834 141.784 197.147 1.00 123.49 ? 368 LYS   A C   1 
ATOM   2481 O  O   . LYS   A 1 319 ? 142.263 141.973 196.068 1.00 130.01 ? 368 LYS   A O   1 
ATOM   2482 C  CB  . LYS   A 1 319 ? 141.920 140.143 198.810 1.00 118.94 ? 368 LYS   A CB  1 
ATOM   2483 C  CG  . LYS   A 1 319 ? 141.546 138.683 199.000 1.00 123.21 ? 368 LYS   A CG  1 
ATOM   2484 C  CD  . LYS   A 1 319 ? 140.673 138.482 200.229 1.00 126.99 ? 368 LYS   A CD  1 
ATOM   2485 C  CE  . LYS   A 1 319 ? 139.568 139.523 200.307 1.00 127.23 ? 368 LYS   A CE  1 
ATOM   2486 N  NZ  . LYS   A 1 319 ? 138.380 139.143 199.495 1.00 123.61 ? 368 LYS   A NZ  1 
ATOM   2487 N  N   . GLU   A 1 320 ? 143.370 142.783 197.850 1.00 130.61 ? 369 GLU   A N   1 
ATOM   2488 C  CA  . GLU   A 1 320 ? 143.302 144.153 197.351 1.00 128.36 ? 369 GLU   A CA  1 
ATOM   2489 C  C   . GLU   A 1 320 ? 144.164 144.335 196.109 1.00 126.18 ? 369 GLU   A C   1 
ATOM   2490 O  O   . GLU   A 1 320 ? 143.790 145.075 195.191 1.00 132.86 ? 369 GLU   A O   1 
ATOM   2491 C  CB  . GLU   A 1 320 ? 143.717 145.134 198.444 1.00 127.27 ? 369 GLU   A CB  1 
ATOM   2492 C  CG  . GLU   A 1 320 ? 143.481 146.585 198.074 1.00 133.12 ? 369 GLU   A CG  1 
ATOM   2493 C  CD  . GLU   A 1 320 ? 142.084 147.055 198.420 1.00 140.05 ? 369 GLU   A CD  1 
ATOM   2494 O  OE1 . GLU   A 1 320 ? 141.299 146.245 198.954 1.00 139.16 ? 369 GLU   A OE1 1 
ATOM   2495 O  OE2 . GLU   A 1 320 ? 141.767 148.232 198.152 1.00 137.96 ? 369 GLU   A OE2 1 
ATOM   2496 N  N   . THR   A 1 321 ? 145.325 143.676 196.063 1.00 99.52  ? 370 THR   A N   1 
ATOM   2497 C  CA  . THR   A 1 321 ? 146.155 143.733 194.865 1.00 95.54  ? 370 THR   A CA  1 
ATOM   2498 C  C   . THR   A 1 321 ? 145.424 143.150 193.666 1.00 104.65 ? 370 THR   A C   1 
ATOM   2499 O  O   . THR   A 1 321 ? 145.457 143.720 192.570 1.00 104.46 ? 370 THR   A O   1 
ATOM   2500 C  CB  . THR   A 1 321 ? 147.466 142.989 195.099 1.00 102.93 ? 370 THR   A CB  1 
ATOM   2501 O  OG1 . THR   A 1 321 ? 148.199 143.633 196.147 1.00 117.26 ? 370 THR   A OG1 1 
ATOM   2502 C  CG2 . THR   A 1 321 ? 148.300 142.978 193.832 1.00 109.06 ? 370 THR   A CG2 1 
ATOM   2503 N  N   . LEU   A 1 322 ? 144.752 142.014 193.858 1.00 114.43 ? 371 LEU   A N   1 
ATOM   2504 C  CA  . LEU   A 1 322 ? 143.989 141.415 192.769 1.00 109.83 ? 371 LEU   A CA  1 
ATOM   2505 C  C   . LEU   A 1 322 ? 142.804 142.289 192.381 1.00 112.35 ? 371 LEU   A C   1 
ATOM   2506 O  O   . LEU   A 1 322 ? 142.437 142.358 191.203 1.00 116.14 ? 371 LEU   A O   1 
ATOM   2507 C  CB  . LEU   A 1 322 ? 143.521 140.017 193.166 1.00 103.38 ? 371 LEU   A CB  1 
ATOM   2508 C  CG  . LEU   A 1 322 ? 144.642 138.994 193.325 1.00 96.43  ? 371 LEU   A CG  1 
ATOM   2509 C  CD1 . LEU   A 1 322 ? 144.227 137.880 194.265 1.00 91.94  ? 371 LEU   A CD1 1 
ATOM   2510 C  CD2 . LEU   A 1 322 ? 145.026 138.442 191.970 1.00 103.02 ? 371 LEU   A CD2 1 
ATOM   2511 N  N   . ARG   A 1 323 ? 142.189 142.956 193.358 1.00 110.49 ? 372 ARG   A N   1 
ATOM   2512 C  CA  . ARG   A 1 323 ? 141.070 143.842 193.061 1.00 103.57 ? 372 ARG   A CA  1 
ATOM   2513 C  C   . ARG   A 1 323 ? 141.515 145.017 192.204 1.00 105.99 ? 372 ARG   A C   1 
ATOM   2514 O  O   . ARG   A 1 323 ? 140.885 145.338 191.190 1.00 113.63 ? 372 ARG   A O   1 
ATOM   2515 C  CB  . ARG   A 1 323 ? 140.436 144.337 194.359 1.00 105.11 ? 372 ARG   A CB  1 
ATOM   2516 C  CG  . ARG   A 1 323 ? 139.383 145.407 194.157 1.00 110.88 ? 372 ARG   A CG  1 
ATOM   2517 C  CD  . ARG   A 1 323 ? 138.936 145.996 195.479 1.00 114.04 ? 372 ARG   A CD  1 
ATOM   2518 N  NE  . ARG   A 1 323 ? 138.661 147.423 195.374 1.00 110.83 ? 372 ARG   A NE  1 
ATOM   2519 C  CZ  . ARG   A 1 323 ? 139.579 148.373 195.482 1.00 115.35 ? 372 ARG   A CZ  1 
ATOM   2520 N  NH1 . ARG   A 1 323 ? 140.850 148.083 195.707 1.00 115.21 ? 372 ARG   A NH1 1 
ATOM   2521 N  NH2 . ARG   A 1 323 ? 139.213 149.645 195.366 1.00 123.24 ? 372 ARG   A NH2 1 
ATOM   2522 N  N   . LEU   A 1 324 ? 142.608 145.672 192.595 1.00 119.90 ? 373 LEU   A N   1 
ATOM   2523 C  CA  . LEU   A 1 324 ? 143.050 146.861 191.875 1.00 118.40 ? 373 LEU   A CA  1 
ATOM   2524 C  C   . LEU   A 1 324 ? 143.645 146.502 190.519 1.00 126.01 ? 373 LEU   A C   1 
ATOM   2525 O  O   . LEU   A 1 324 ? 143.320 147.129 189.504 1.00 130.67 ? 373 LEU   A O   1 
ATOM   2526 C  CB  . LEU   A 1 324 ? 144.059 147.639 192.718 1.00 116.75 ? 373 LEU   A CB  1 
ATOM   2527 C  CG  . LEU   A 1 324 ? 143.456 148.656 193.686 1.00 120.93 ? 373 LEU   A CG  1 
ATOM   2528 C  CD1 . LEU   A 1 324 ? 144.506 149.154 194.659 1.00 124.87 ? 373 LEU   A CD1 1 
ATOM   2529 C  CD2 . LEU   A 1 324 ? 142.836 149.812 192.925 1.00 124.57 ? 373 LEU   A CD2 1 
ATOM   2530 N  N   . ARG   A 1 325 ? 144.510 145.488 190.477 1.00 121.87 ? 374 ARG   A N   1 
ATOM   2531 C  CA  . ARG   A 1 325 ? 145.260 145.131 189.273 1.00 115.56 ? 374 ARG   A CA  1 
ATOM   2532 C  C   . ARG   A 1 325 ? 145.090 143.645 188.991 1.00 115.52 ? 374 ARG   A C   1 
ATOM   2533 O  O   . ARG   A 1 325 ? 145.992 142.842 189.264 1.00 122.38 ? 374 ARG   A O   1 
ATOM   2534 C  CB  . ARG   A 1 325 ? 146.739 145.489 189.425 1.00 114.00 ? 374 ARG   A CB  1 
ATOM   2535 C  CG  . ARG   A 1 325 ? 146.996 146.954 189.721 1.00 119.79 ? 374 ARG   A CG  1 
ATOM   2536 C  CD  . ARG   A 1 325 ? 146.385 147.848 188.658 1.00 117.31 ? 374 ARG   A CD  1 
ATOM   2537 N  NE  . ARG   A 1 325 ? 147.225 149.005 188.377 1.00 118.08 ? 374 ARG   A NE  1 
ATOM   2538 C  CZ  . ARG   A 1 325 ? 147.127 150.171 189.000 1.00 124.10 ? 374 ARG   A CZ  1 
ATOM   2539 N  NH1 . ARG   A 1 325 ? 146.227 150.374 189.948 1.00 124.47 ? 374 ARG   A NH1 1 
ATOM   2540 N  NH2 . ARG   A 1 325 ? 147.952 151.158 188.664 1.00 124.18 ? 374 ARG   A NH2 1 
ATOM   2541 N  N   . PRO   A 1 326 ? 143.947 143.242 188.446 1.00 109.09 ? 375 PRO   A N   1 
ATOM   2542 C  CA  . PRO   A 1 326 ? 143.742 141.833 188.110 1.00 112.64 ? 375 PRO   A CA  1 
ATOM   2543 C  C   . PRO   A 1 326 ? 144.590 141.435 186.918 1.00 109.94 ? 375 PRO   A C   1 
ATOM   2544 O  O   . PRO   A 1 326 ? 144.751 142.219 185.971 1.00 113.89 ? 375 PRO   A O   1 
ATOM   2545 C  CB  . PRO   A 1 326 ? 142.243 141.759 187.773 1.00 108.63 ? 375 PRO   A CB  1 
ATOM   2546 C  CG  . PRO   A 1 326 ? 141.666 143.072 188.207 1.00 110.79 ? 375 PRO   A CG  1 
ATOM   2547 C  CD  . PRO   A 1 326 ? 142.775 144.057 188.100 1.00 108.07 ? 375 PRO   A CD  1 
ATOM   2548 N  N   . PRO   A 1 327 ? 145.157 140.230 186.928 1.00 95.75  ? 376 PRO   A N   1 
ATOM   2549 C  CA  . PRO   A 1 327 ? 145.910 139.759 185.759 1.00 96.62  ? 376 PRO   A CA  1 
ATOM   2550 C  C   . PRO   A 1 327 ? 145.020 139.607 184.539 1.00 108.80 ? 376 PRO   A C   1 
ATOM   2551 O  O   . PRO   A 1 327 ? 145.300 140.174 183.478 1.00 111.58 ? 376 PRO   A O   1 
ATOM   2552 C  CB  . PRO   A 1 327 ? 146.464 138.404 186.217 1.00 108.90 ? 376 PRO   A CB  1 
ATOM   2553 C  CG  . PRO   A 1 327 ? 146.394 138.444 187.700 1.00 101.65 ? 376 PRO   A CG  1 
ATOM   2554 C  CD  . PRO   A 1 327 ? 145.195 139.261 188.032 1.00 103.10 ? 376 PRO   A CD  1 
ATOM   2555 N  N   . ILE   A 1 328 ? 143.940 138.844 184.685 1.00 108.83 ? 377 ILE   A N   1 
ATOM   2556 C  CA  . ILE   A 1 328 ? 142.991 138.613 183.603 1.00 104.41 ? 377 ILE   A CA  1 
ATOM   2557 C  C   . ILE   A 1 328 ? 141.949 139.723 183.681 1.00 109.03 ? 377 ILE   A C   1 
ATOM   2558 O  O   . ILE   A 1 328 ? 141.032 139.677 184.501 1.00 111.53 ? 377 ILE   A O   1 
ATOM   2559 C  CB  . ILE   A 1 328 ? 142.351 137.228 183.696 1.00 99.55  ? 377 ILE   A CB  1 
ATOM   2560 C  CG1 . ILE   A 1 328 ? 143.430 136.149 183.691 1.00 100.48 ? 377 ILE   A CG1 1 
ATOM   2561 C  CG2 . ILE   A 1 328 ? 141.390 137.014 182.545 1.00 110.09 ? 377 ILE   A CG2 1 
ATOM   2562 C  CD1 . ILE   A 1 328 ? 144.260 136.139 182.438 1.00 102.07 ? 377 ILE   A CD1 1 
ATOM   2563 N  N   . MET   A 1 329 ? 142.094 140.730 182.822 1.00 119.05 ? 378 MET   A N   1 
ATOM   2564 C  CA  . MET   A 1 329 ? 141.179 141.862 182.829 1.00 121.06 ? 378 MET   A CA  1 
ATOM   2565 C  C   . MET   A 1 329 ? 139.919 141.617 182.013 1.00 122.03 ? 378 MET   A C   1 
ATOM   2566 O  O   . MET   A 1 329 ? 138.975 142.408 182.117 1.00 124.56 ? 378 MET   A O   1 
ATOM   2567 C  CB  . MET   A 1 329 ? 141.891 143.115 182.313 1.00 122.93 ? 378 MET   A CB  1 
ATOM   2568 C  CG  . MET   A 1 329 ? 141.710 143.370 180.826 1.00 130.42 ? 378 MET   A CG  1 
ATOM   2569 S  SD  . MET   A 1 329 ? 142.677 144.774 180.240 1.00 146.21 ? 378 MET   A SD  1 
ATOM   2570 C  CE  . MET   A 1 329 ? 142.746 144.431 178.484 1.00 121.73 ? 378 MET   A CE  1 
ATOM   2571 N  N   . ILE   A 1 330 ? 139.872 140.551 181.219 1.00 110.92 ? 379 ILE   A N   1 
ATOM   2572 C  CA  . ILE   A 1 330 ? 138.729 140.272 180.356 1.00 109.67 ? 379 ILE   A CA  1 
ATOM   2573 C  C   . ILE   A 1 330 ? 138.570 138.764 180.234 1.00 111.11 ? 379 ILE   A C   1 
ATOM   2574 O  O   . ILE   A 1 330 ? 139.527 138.057 179.904 1.00 121.13 ? 379 ILE   A O   1 
ATOM   2575 C  CB  . ILE   A 1 330 ? 138.896 140.915 178.964 1.00 109.22 ? 379 ILE   A CB  1 
ATOM   2576 C  CG1 . ILE   A 1 330 ? 138.504 142.391 178.999 1.00 104.87 ? 379 ILE   A CG1 1 
ATOM   2577 C  CG2 . ILE   A 1 330 ? 138.064 140.181 177.928 1.00 114.40 ? 379 ILE   A CG2 1 
ATOM   2578 C  CD1 . ILE   A 1 330 ? 139.257 143.238 178.004 1.00 113.94 ? 379 ILE   A CD1 1 
ATOM   2579 N  N   . MET   A 1 331 ? 137.366 138.270 180.504 1.00 100.56 ? 380 MET   A N   1 
ATOM   2580 C  CA  . MET   A 1 331 ? 137.018 136.871 180.284 1.00 110.50 ? 380 MET   A CA  1 
ATOM   2581 C  C   . MET   A 1 331 ? 135.977 136.820 179.173 1.00 117.35 ? 380 MET   A C   1 
ATOM   2582 O  O   . MET   A 1 331 ? 134.799 137.109 179.405 1.00 128.80 ? 380 MET   A O   1 
ATOM   2583 C  CB  . MET   A 1 331 ? 136.499 136.217 181.562 1.00 113.76 ? 380 MET   A CB  1 
ATOM   2584 C  CG  . MET   A 1 331 ? 137.237 136.637 182.818 1.00 114.67 ? 380 MET   A CG  1 
ATOM   2585 S  SD  . MET   A 1 331 ? 136.435 136.063 184.327 1.00 130.08 ? 380 MET   A SD  1 
ATOM   2586 C  CE  . MET   A 1 331 ? 135.387 134.761 183.684 1.00 110.64 ? 380 MET   A CE  1 
ATOM   2587 N  N   . MET   A 1 332 ? 136.412 136.451 177.975 1.00 115.72 ? 381 MET   A N   1 
ATOM   2588 C  CA  . MET   A 1 332 ? 135.558 136.465 176.799 1.00 113.34 ? 381 MET   A CA  1 
ATOM   2589 C  C   . MET   A 1 332 ? 134.704 135.208 176.722 1.00 107.79 ? 381 MET   A C   1 
ATOM   2590 O  O   . MET   A 1 332 ? 135.052 134.159 177.269 1.00 111.32 ? 381 MET   A O   1 
ATOM   2591 C  CB  . MET   A 1 332 ? 136.401 136.589 175.530 1.00 113.16 ? 381 MET   A CB  1 
ATOM   2592 C  CG  . MET   A 1 332 ? 136.326 137.942 174.862 1.00 109.53 ? 381 MET   A CG  1 
ATOM   2593 S  SD  . MET   A 1 332 ? 137.701 138.240 173.739 1.00 141.31 ? 381 MET   A SD  1 
ATOM   2594 C  CE  . MET   A 1 332 ? 139.077 138.239 174.884 1.00 119.11 ? 381 MET   A CE  1 
ATOM   2595 N  N   . ARG   A 1 333 ? 133.575 135.330 176.028 1.00 96.19  ? 382 ARG   A N   1 
ATOM   2596 C  CA  . ARG   A 1 333 ? 132.704 134.206 175.718 1.00 90.25  ? 382 ARG   A CA  1 
ATOM   2597 C  C   . ARG   A 1 333 ? 132.087 134.459 174.351 1.00 97.73  ? 382 ARG   A C   1 
ATOM   2598 O  O   . ARG   A 1 333 ? 131.988 135.602 173.901 1.00 115.73 ? 382 ARG   A O   1 
ATOM   2599 C  CB  . ARG   A 1 333 ? 131.603 134.024 176.769 1.00 101.71 ? 382 ARG   A CB  1 
ATOM   2600 C  CG  . ARG   A 1 333 ? 132.069 133.514 178.125 1.00 104.60 ? 382 ARG   A CG  1 
ATOM   2601 C  CD  . ARG   A 1 333 ? 132.753 132.164 178.024 1.00 113.61 ? 382 ARG   A CD  1 
ATOM   2602 N  NE  . ARG   A 1 333 ? 133.390 131.788 179.280 1.00 104.65 ? 382 ARG   A NE  1 
ATOM   2603 C  CZ  . ARG   A 1 333 ? 134.693 131.858 179.511 1.00 103.70 ? 382 ARG   A CZ  1 
ATOM   2604 N  NH1 . ARG   A 1 333 ? 135.535 132.300 178.592 1.00 105.38 ? 382 ARG   A NH1 1 
ATOM   2605 N  NH2 . ARG   A 1 333 ? 135.164 131.479 180.695 1.00 108.05 ? 382 ARG   A NH2 1 
ATOM   2606 N  N   . MET   A 1 334 ? 131.667 133.385 173.691 1.00 113.02 ? 383 MET   A N   1 
ATOM   2607 C  CA  . MET   A 1 334 ? 131.031 133.478 172.382 1.00 119.11 ? 383 MET   A CA  1 
ATOM   2608 C  C   . MET   A 1 334 ? 129.562 133.107 172.509 1.00 123.41 ? 383 MET   A C   1 
ATOM   2609 O  O   . MET   A 1 334 ? 129.234 131.961 172.835 1.00 125.88 ? 383 MET   A O   1 
ATOM   2610 C  CB  . MET   A 1 334 ? 131.718 132.575 171.360 1.00 124.96 ? 383 MET   A CB  1 
ATOM   2611 C  CG  . MET   A 1 334 ? 131.275 132.826 169.931 1.00 125.86 ? 383 MET   A CG  1 
ATOM   2612 S  SD  . MET   A 1 334 ? 132.397 133.920 169.042 1.00 139.68 ? 383 MET   A SD  1 
ATOM   2613 C  CE  . MET   A 1 334 ? 131.658 133.911 167.411 1.00 127.73 ? 383 MET   A CE  1 
ATOM   2614 N  N   . ALA   A 1 335 ? 128.686 134.072 172.249 1.00 127.48 ? 384 ALA   A N   1 
ATOM   2615 C  CA  . ALA   A 1 335 ? 127.257 133.803 172.258 1.00 125.75 ? 384 ALA   A CA  1 
ATOM   2616 C  C   . ALA   A 1 335 ? 126.874 132.929 171.072 1.00 130.30 ? 384 ALA   A C   1 
ATOM   2617 O  O   . ALA   A 1 335 ? 127.337 133.138 169.949 1.00 134.45 ? 384 ALA   A O   1 
ATOM   2618 C  CB  . ALA   A 1 335 ? 126.469 135.110 172.220 1.00 120.43 ? 384 ALA   A CB  1 
ATOM   2619 N  N   . ARG   A 1 336 ? 126.019 131.941 171.329 1.00 138.83 ? 385 ARG   A N   1 
ATOM   2620 C  CA  . ARG   A 1 336 ? 125.515 131.069 170.280 1.00 140.39 ? 385 ARG   A CA  1 
ATOM   2621 C  C   . ARG   A 1 336 ? 124.007 130.883 170.321 1.00 141.25 ? 385 ARG   A C   1 
ATOM   2622 O  O   . ARG   A 1 336 ? 123.441 130.369 169.350 1.00 140.54 ? 385 ARG   A O   1 
ATOM   2623 C  CB  . ARG   A 1 336 ? 126.201 129.696 170.347 1.00 139.28 ? 385 ARG   A CB  1 
ATOM   2624 C  CG  . ARG   A 1 336 ? 127.600 129.692 169.747 1.00 139.20 ? 385 ARG   A CG  1 
ATOM   2625 C  CD  . ARG   A 1 336 ? 128.239 128.317 169.815 1.00 137.74 ? 385 ARG   A CD  1 
ATOM   2626 N  NE  . ARG   A 1 336 ? 127.989 127.666 171.094 1.00 138.68 ? 385 ARG   A NE  1 
ATOM   2627 C  CZ  . ARG   A 1 336 ? 128.109 126.363 171.305 1.00 144.81 ? 385 ARG   A CZ  1 
ATOM   2628 N  NH1 . ARG   A 1 336 ? 128.484 125.538 170.341 1.00 144.16 ? 385 ARG   A NH1 1 
ATOM   2629 N  NH2 . ARG   A 1 336 ? 127.846 125.875 172.514 1.00 147.83 ? 385 ARG   A NH2 1 
ATOM   2630 N  N   . THR   A 1 337 ? 123.344 131.282 171.401 1.00 139.56 ? 386 THR   A N   1 
ATOM   2631 C  CA  . THR   A 1 337 ? 121.898 131.315 171.525 1.00 137.15 ? 386 THR   A CA  1 
ATOM   2632 C  C   . THR   A 1 337 ? 121.490 132.676 172.068 1.00 135.81 ? 386 THR   A C   1 
ATOM   2633 O  O   . THR   A 1 337 ? 122.262 133.308 172.795 1.00 135.60 ? 386 THR   A O   1 
ATOM   2634 C  CB  . THR   A 1 337 ? 121.394 130.200 172.455 1.00 135.56 ? 386 THR   A CB  1 
ATOM   2635 O  OG1 . THR   A 1 337 ? 119.980 130.324 172.650 1.00 135.31 ? 386 THR   A OG1 1 
ATOM   2636 C  CG2 . THR   A 1 337 ? 122.092 130.269 173.800 1.00 136.92 ? 386 THR   A CG2 1 
ATOM   2637 N  N   . PRO   A 1 338 ? 120.306 133.169 171.710 1.00 131.42 ? 387 PRO   A N   1 
ATOM   2638 C  CA  . PRO   A 1 338 ? 119.880 134.481 172.215 1.00 130.09 ? 387 PRO   A CA  1 
ATOM   2639 C  C   . PRO   A 1 338 ? 119.736 134.474 173.730 1.00 135.40 ? 387 PRO   A C   1 
ATOM   2640 O  O   . PRO   A 1 338 ? 119.081 133.603 174.306 1.00 140.28 ? 387 PRO   A O   1 
ATOM   2641 C  CB  . PRO   A 1 338 ? 118.536 134.713 171.518 1.00 133.45 ? 387 PRO   A CB  1 
ATOM   2642 C  CG  . PRO   A 1 338 ? 118.556 133.823 170.329 1.00 138.29 ? 387 PRO   A CG  1 
ATOM   2643 C  CD  . PRO   A 1 338 ? 119.375 132.633 170.703 1.00 135.64 ? 387 PRO   A CD  1 
ATOM   2644 N  N   . GLN   A 1 339 ? 120.356 135.462 174.374 1.00 137.47 ? 388 GLN   A N   1 
ATOM   2645 C  CA  . GLN   A 1 339 ? 120.306 135.620 175.819 1.00 135.55 ? 388 GLN   A CA  1 
ATOM   2646 C  C   . GLN   A 1 339 ? 119.864 137.035 176.157 1.00 140.89 ? 388 GLN   A C   1 
ATOM   2647 O  O   . GLN   A 1 339 ? 120.094 137.973 175.390 1.00 143.53 ? 388 GLN   A O   1 
ATOM   2648 C  CB  . GLN   A 1 339 ? 121.665 135.335 176.469 1.00 128.90 ? 388 GLN   A CB  1 
ATOM   2649 C  CG  . GLN   A 1 339 ? 122.479 134.281 175.755 1.00 131.38 ? 388 GLN   A CG  1 
ATOM   2650 C  CD  . GLN   A 1 339 ? 123.342 133.474 176.696 1.00 139.31 ? 388 GLN   A CD  1 
ATOM   2651 O  OE1 . GLN   A 1 339 ? 122.998 133.282 177.861 1.00 143.04 ? 388 GLN   A OE1 1 
ATOM   2652 N  NE2 . GLN   A 1 339 ? 124.468 132.986 176.193 1.00 139.84 ? 388 GLN   A NE2 1 
ATOM   2653 N  N   . THR   A 1 340 ? 119.231 137.183 177.318 1.00 145.15 ? 389 THR   A N   1 
ATOM   2654 C  CA  . THR   A 1 340 ? 118.708 138.464 177.770 1.00 145.01 ? 389 THR   A CA  1 
ATOM   2655 C  C   . THR   A 1 340 ? 119.332 138.832 179.108 1.00 142.31 ? 389 THR   A C   1 
ATOM   2656 O  O   . THR   A 1 340 ? 119.264 138.053 180.064 1.00 142.89 ? 389 THR   A O   1 
ATOM   2657 C  CB  . THR   A 1 340 ? 117.184 138.424 177.902 1.00 142.64 ? 389 THR   A CB  1 
ATOM   2658 O  OG1 . THR   A 1 340 ? 116.608 137.965 176.672 1.00 141.38 ? 389 THR   A OG1 1 
ATOM   2659 C  CG2 . THR   A 1 340 ? 116.642 139.806 178.228 1.00 138.41 ? 389 THR   A CG2 1 
ATOM   2660 N  N   . VAL   A 1 341 ? 119.938 140.014 179.169 1.00 139.35 ? 390 VAL   A N   1 
ATOM   2661 C  CA  . VAL   A 1 341 ? 120.455 140.572 180.413 1.00 141.90 ? 390 VAL   A CA  1 
ATOM   2662 C  C   . VAL   A 1 341 ? 120.123 142.058 180.448 1.00 144.27 ? 390 VAL   A C   1 
ATOM   2663 O  O   . VAL   A 1 341 ? 120.290 142.768 179.450 1.00 142.35 ? 390 VAL   A O   1 
ATOM   2664 C  CB  . VAL   A 1 341 ? 121.972 140.322 180.569 1.00 141.23 ? 390 VAL   A CB  1 
ATOM   2665 C  CG1 . VAL   A 1 341 ? 122.762 141.014 179.466 1.00 139.56 ? 390 VAL   A CG1 1 
ATOM   2666 C  CG2 . VAL   A 1 341 ? 122.446 140.774 181.941 1.00 135.45 ? 390 VAL   A CG2 1 
ATOM   2667 N  N   . ALA   A 1 342 ? 119.619 142.518 181.596 1.00 152.31 ? 391 ALA   A N   1 
ATOM   2668 C  CA  . ALA   A 1 342 ? 119.206 143.911 181.783 1.00 149.97 ? 391 ALA   A CA  1 
ATOM   2669 C  C   . ALA   A 1 342 ? 118.168 144.336 180.745 1.00 152.48 ? 391 ALA   A C   1 
ATOM   2670 O  O   . ALA   A 1 342 ? 118.062 145.513 180.396 1.00 151.49 ? 391 ALA   A O   1 
ATOM   2671 C  CB  . ALA   A 1 342 ? 120.411 144.856 181.761 1.00 145.51 ? 391 ALA   A CB  1 
ATOM   2672 N  N   . GLY   A 1 343 ? 117.394 143.375 180.245 1.00 147.31 ? 392 GLY   A N   1 
ATOM   2673 C  CA  . GLY   A 1 343 ? 116.375 143.647 179.255 1.00 142.81 ? 392 GLY   A CA  1 
ATOM   2674 C  C   . GLY   A 1 343 ? 116.866 143.754 177.828 1.00 143.29 ? 392 GLY   A C   1 
ATOM   2675 O  O   . GLY   A 1 343 ? 116.049 143.976 176.926 1.00 144.02 ? 392 GLY   A O   1 
ATOM   2676 N  N   . TYR   A 1 344 ? 118.166 143.604 177.589 1.00 140.53 ? 393 TYR   A N   1 
ATOM   2677 C  CA  . TYR   A 1 344 ? 118.747 143.719 176.258 1.00 139.03 ? 393 TYR   A CA  1 
ATOM   2678 C  C   . TYR   A 1 344 ? 119.152 142.334 175.772 1.00 147.42 ? 393 TYR   A C   1 
ATOM   2679 O  O   . TYR   A 1 344 ? 119.931 141.643 176.437 1.00 148.24 ? 393 TYR   A O   1 
ATOM   2680 C  CB  . TYR   A 1 344 ? 119.951 144.659 176.271 1.00 137.53 ? 393 TYR   A CB  1 
ATOM   2681 C  CG  . TYR   A 1 344 ? 119.598 146.088 176.606 1.00 140.75 ? 393 TYR   A CG  1 
ATOM   2682 C  CD1 . TYR   A 1 344 ? 118.819 146.848 175.746 1.00 142.47 ? 393 TYR   A CD1 1 
ATOM   2683 C  CD2 . TYR   A 1 344 ? 120.038 146.676 177.783 1.00 141.38 ? 393 TYR   A CD2 1 
ATOM   2684 C  CE1 . TYR   A 1 344 ? 118.490 148.153 176.045 1.00 141.60 ? 393 TYR   A CE1 1 
ATOM   2685 C  CE2 . TYR   A 1 344 ? 119.714 147.982 178.092 1.00 142.59 ? 393 TYR   A CE2 1 
ATOM   2686 C  CZ  . TYR   A 1 344 ? 118.939 148.716 177.218 1.00 142.77 ? 393 TYR   A CZ  1 
ATOM   2687 O  OH  . TYR   A 1 344 ? 118.611 150.018 177.517 1.00 144.93 ? 393 TYR   A OH  1 
ATOM   2688 N  N   . THR   A 1 345 ? 118.628 141.935 174.616 1.00 147.22 ? 394 THR   A N   1 
ATOM   2689 C  CA  . THR   A 1 345 ? 118.907 140.623 174.049 1.00 139.05 ? 394 THR   A CA  1 
ATOM   2690 C  C   . THR   A 1 345 ? 120.196 140.669 173.240 1.00 135.71 ? 394 THR   A C   1 
ATOM   2691 O  O   . THR   A 1 345 ? 120.364 141.535 172.377 1.00 139.45 ? 394 THR   A O   1 
ATOM   2692 C  CB  . THR   A 1 345 ? 117.751 140.157 173.163 1.00 131.62 ? 394 THR   A CB  1 
ATOM   2693 O  OG1 . THR   A 1 345 ? 117.465 141.161 172.182 1.00 135.64 ? 394 THR   A OG1 1 
ATOM   2694 C  CG2 . THR   A 1 345 ? 116.507 139.906 173.998 1.00 132.13 ? 394 THR   A CG2 1 
ATOM   2695 N  N   . ILE   A 1 346 ? 121.101 139.736 173.521 1.00 118.48 ? 395 ILE   A N   1 
ATOM   2696 C  CA  . ILE   A 1 346 ? 122.366 139.622 172.802 1.00 117.10 ? 395 ILE   A CA  1 
ATOM   2697 C  C   . ILE   A 1 346 ? 122.199 138.536 171.742 1.00 129.47 ? 395 ILE   A C   1 
ATOM   2698 O  O   . ILE   A 1 346 ? 122.081 137.352 172.099 1.00 135.76 ? 395 ILE   A O   1 
ATOM   2699 C  CB  . ILE   A 1 346 ? 123.527 139.294 173.747 1.00 115.47 ? 395 ILE   A CB  1 
ATOM   2700 C  CG1 . ILE   A 1 346 ? 123.460 140.170 174.998 1.00 124.24 ? 395 ILE   A CG1 1 
ATOM   2701 C  CG2 . ILE   A 1 346 ? 124.856 139.474 173.033 1.00 114.09 ? 395 ILE   A CG2 1 
ATOM   2702 C  CD1 . ILE   A 1 346 ? 124.696 140.090 175.867 1.00 121.82 ? 395 ILE   A CD1 1 
ATOM   2703 N  N   . PRO   A 1 347 ? 122.182 138.877 170.452 1.00 143.33 ? 396 PRO   A N   1 
ATOM   2704 C  CA  . PRO   A 1 347 ? 122.040 137.844 169.432 1.00 138.71 ? 396 PRO   A CA  1 
ATOM   2705 C  C   . PRO   A 1 347 ? 123.300 137.005 169.339 1.00 134.33 ? 396 PRO   A C   1 
ATOM   2706 O  O   . PRO   A 1 347 ? 124.396 137.464 169.702 1.00 140.68 ? 396 PRO   A O   1 
ATOM   2707 C  CB  . PRO   A 1 347 ? 121.803 138.650 168.143 1.00 140.31 ? 396 PRO   A CB  1 
ATOM   2708 C  CG  . PRO   A 1 347 ? 122.469 139.952 168.396 1.00 139.18 ? 396 PRO   A CG  1 
ATOM   2709 C  CD  . PRO   A 1 347 ? 122.341 140.222 169.872 1.00 136.97 ? 396 PRO   A CD  1 
ATOM   2710 N  N   . PRO   A 1 348 ? 123.193 135.763 168.871 1.00 134.79 ? 397 PRO   A N   1 
ATOM   2711 C  CA  . PRO   A 1 348 ? 124.390 134.931 168.710 1.00 138.15 ? 397 PRO   A CA  1 
ATOM   2712 C  C   . PRO   A 1 348 ? 125.385 135.564 167.750 1.00 139.51 ? 397 PRO   A C   1 
ATOM   2713 O  O   . PRO   A 1 348 ? 125.015 136.236 166.786 1.00 138.65 ? 397 PRO   A O   1 
ATOM   2714 C  CB  . PRO   A 1 348 ? 123.837 133.615 168.153 1.00 140.51 ? 397 PRO   A CB  1 
ATOM   2715 C  CG  . PRO   A 1 348 ? 122.412 133.589 168.582 1.00 145.16 ? 397 PRO   A CG  1 
ATOM   2716 C  CD  . PRO   A 1 348 ? 121.953 135.017 168.604 1.00 140.92 ? 397 PRO   A CD  1 
ATOM   2717 N  N   . GLY   A 1 349 ? 126.666 135.340 168.030 1.00 144.01 ? 398 GLY   A N   1 
ATOM   2718 C  CA  . GLY   A 1 349 ? 127.753 135.889 167.249 1.00 142.74 ? 398 GLY   A CA  1 
ATOM   2719 C  C   . GLY   A 1 349 ? 128.489 137.026 167.923 1.00 139.93 ? 398 GLY   A C   1 
ATOM   2720 O  O   . GLY   A 1 349 ? 129.618 137.337 167.525 1.00 141.88 ? 398 GLY   A O   1 
ATOM   2721 N  N   . HIS   A 1 350 ? 127.887 137.653 168.930 1.00 125.22 ? 399 HIS   A N   1 
ATOM   2722 C  CA  . HIS   A 1 350 ? 128.556 138.714 169.668 1.00 121.61 ? 399 HIS   A CA  1 
ATOM   2723 C  C   . HIS   A 1 350 ? 129.502 138.109 170.695 1.00 124.89 ? 399 HIS   A C   1 
ATOM   2724 O  O   . HIS   A 1 350 ? 129.136 137.174 171.413 1.00 127.57 ? 399 HIS   A O   1 
ATOM   2725 C  CB  . HIS   A 1 350 ? 127.537 139.618 170.361 1.00 121.27 ? 399 HIS   A CB  1 
ATOM   2726 C  CG  . HIS   A 1 350 ? 126.658 140.380 169.418 1.00 127.38 ? 399 HIS   A CG  1 
ATOM   2727 N  ND1 . HIS   A 1 350 ? 125.977 141.516 169.795 1.00 125.58 ? 399 HIS   A ND1 1 
ATOM   2728 C  CD2 . HIS   A 1 350 ? 126.347 140.168 168.118 1.00 130.99 ? 399 HIS   A CD2 1 
ATOM   2729 C  CE1 . HIS   A 1 350 ? 125.285 141.974 168.766 1.00 126.63 ? 399 HIS   A CE1 1 
ATOM   2730 N  NE2 . HIS   A 1 350 ? 125.492 141.173 167.736 1.00 131.54 ? 399 HIS   A NE2 1 
ATOM   2731 N  N   . GLN   A 1 351 ? 130.717 138.644 170.764 1.00 106.63 ? 400 GLN   A N   1 
ATOM   2732 C  CA  . GLN   A 1 351 ? 131.703 138.193 171.742 1.00 98.72  ? 400 GLN   A CA  1 
ATOM   2733 C  C   . GLN   A 1 351 ? 131.328 138.780 173.094 1.00 105.32 ? 400 GLN   A C   1 
ATOM   2734 O  O   . GLN   A 1 351 ? 131.795 139.851 173.482 1.00 106.51 ? 400 GLN   A O   1 
ATOM   2735 C  CB  . GLN   A 1 351 ? 133.108 138.609 171.327 1.00 98.49  ? 400 GLN   A CB  1 
ATOM   2736 C  CG  . GLN   A 1 351 ? 133.476 138.218 169.913 1.00 111.25 ? 400 GLN   A CG  1 
ATOM   2737 C  CD  . GLN   A 1 351 ? 134.289 136.945 169.861 1.00 115.99 ? 400 GLN   A CD  1 
ATOM   2738 O  OE1 . GLN   A 1 351 ? 135.170 136.724 170.691 1.00 117.27 ? 400 GLN   A OE1 1 
ATOM   2739 N  NE2 . GLN   A 1 351 ? 133.999 136.097 168.882 1.00 108.15 ? 400 GLN   A NE2 1 
ATOM   2740 N  N   . VAL   A 1 352 ? 130.462 138.070 173.820 1.00 98.13  ? 401 VAL   A N   1 
ATOM   2741 C  CA  . VAL   A 1 352 ? 130.071 138.521 175.148 1.00 86.19  ? 401 VAL   A CA  1 
ATOM   2742 C  C   . VAL   A 1 352 ? 131.299 138.579 176.039 1.00 74.79  ? 401 VAL   A C   1 
ATOM   2743 O  O   . VAL   A 1 352 ? 132.093 137.633 176.105 1.00 109.98 ? 401 VAL   A O   1 
ATOM   2744 C  CB  . VAL   A 1 352 ? 128.996 137.598 175.742 1.00 92.79  ? 401 VAL   A CB  1 
ATOM   2745 C  CG1 . VAL   A 1 352 ? 128.372 138.240 176.963 1.00 89.23  ? 401 VAL   A CG1 1 
ATOM   2746 C  CG2 . VAL   A 1 352 ? 127.935 137.295 174.706 1.00 102.46 ? 401 VAL   A CG2 1 
ATOM   2747 N  N   . CYS   A 1 353 ? 131.462 139.699 176.732 1.00 78.78  ? 402 CYS   A N   1 
ATOM   2748 C  CA  . CYS   A 1 353 ? 132.666 139.971 177.494 1.00 86.51  ? 402 CYS   A CA  1 
ATOM   2749 C  C   . CYS   A 1 353 ? 132.311 140.209 178.953 1.00 99.22  ? 402 CYS   A C   1 
ATOM   2750 O  O   . CYS   A 1 353 ? 131.141 140.224 179.343 1.00 112.69 ? 402 CYS   A O   1 
ATOM   2751 C  CB  . CYS   A 1 353 ? 133.411 141.189 176.937 1.00 101.17 ? 402 CYS   A CB  1 
ATOM   2752 S  SG  . CYS   A 1 353 ? 134.688 140.821 175.725 1.00 121.52 ? 402 CYS   A SG  1 
ATOM   2753 N  N   . VAL   A 1 354 ? 133.356 140.390 179.758 1.00 90.41  ? 403 VAL   A N   1 
ATOM   2754 C  CA  . VAL   A 1 354 ? 133.219 140.808 181.146 1.00 90.67  ? 403 VAL   A CA  1 
ATOM   2755 C  C   . VAL   A 1 354 ? 134.583 141.307 181.589 1.00 98.97  ? 403 VAL   A C   1 
ATOM   2756 O  O   . VAL   A 1 354 ? 135.616 140.816 181.128 1.00 116.06 ? 403 VAL   A O   1 
ATOM   2757 C  CB  . VAL   A 1 354 ? 132.694 139.658 182.044 1.00 94.70  ? 403 VAL   A CB  1 
ATOM   2758 C  CG1 . VAL   A 1 354 ? 133.766 138.609 182.263 1.00 98.68  ? 403 VAL   A CG1 1 
ATOM   2759 C  CG2 . VAL   A 1 354 ? 132.201 140.207 183.366 1.00 99.23  ? 403 VAL   A CG2 1 
ATOM   2760 N  N   . SER   A 1 355 ? 134.588 142.307 182.463 1.00 98.25  ? 404 SER   A N   1 
ATOM   2761 C  CA  . SER   A 1 355 ? 135.834 142.944 182.885 1.00 110.45 ? 404 SER   A CA  1 
ATOM   2762 C  C   . SER   A 1 355 ? 136.038 142.757 184.380 1.00 104.28 ? 404 SER   A C   1 
ATOM   2763 O  O   . SER   A 1 355 ? 135.491 143.530 185.188 1.00 117.29 ? 404 SER   A O   1 
ATOM   2764 C  CB  . SER   A 1 355 ? 135.835 144.428 182.526 1.00 108.78 ? 404 SER   A CB  1 
ATOM   2765 O  OG  . SER   A 1 355 ? 137.155 144.941 182.521 1.00 107.41 ? 404 SER   A OG  1 
ATOM   2766 N  N   . PRO   A 1 356 ? 136.808 141.749 184.798 1.00 98.89  ? 405 PRO   A N   1 
ATOM   2767 C  CA  . PRO   A 1 356 ? 137.157 141.616 186.218 1.00 100.43 ? 405 PRO   A CA  1 
ATOM   2768 C  C   . PRO   A 1 356 ? 138.039 142.734 186.747 1.00 112.15 ? 405 PRO   A C   1 
ATOM   2769 O  O   . PRO   A 1 356 ? 138.457 142.663 187.906 1.00 120.78 ? 405 PRO   A O   1 
ATOM   2770 C  CB  . PRO   A 1 356 ? 137.892 140.270 186.267 1.00 108.34 ? 405 PRO   A CB  1 
ATOM   2771 C  CG  . PRO   A 1 356 ? 137.359 139.519 185.105 1.00 109.96 ? 405 PRO   A CG  1 
ATOM   2772 C  CD  . PRO   A 1 356 ? 137.184 140.551 184.033 1.00 114.07 ? 405 PRO   A CD  1 
ATOM   2773 N  N   . THR   A 1 357 ? 138.364 143.744 185.943 1.00 116.47 ? 406 THR   A N   1 
ATOM   2774 C  CA  . THR   A 1 357 ? 139.069 144.924 186.425 1.00 118.01 ? 406 THR   A CA  1 
ATOM   2775 C  C   . THR   A 1 357 ? 138.122 146.090 186.679 1.00 119.02 ? 406 THR   A C   1 
ATOM   2776 O  O   . THR   A 1 357 ? 138.173 146.711 187.743 1.00 125.95 ? 406 THR   A O   1 
ATOM   2777 C  CB  . THR   A 1 357 ? 140.154 145.345 185.429 1.00 120.60 ? 406 THR   A CB  1 
ATOM   2778 O  OG1 . THR   A 1 357 ? 141.056 144.253 185.214 1.00 122.06 ? 406 THR   A OG1 1 
ATOM   2779 C  CG2 . THR   A 1 357 ? 140.931 146.533 185.965 1.00 117.81 ? 406 THR   A CG2 1 
ATOM   2780 N  N   . VAL   A 1 358 ? 137.253 146.397 185.713 1.00 107.27 ? 407 VAL   A N   1 
ATOM   2781 C  CA  . VAL   A 1 358 ? 136.269 147.453 185.915 1.00 104.05 ? 407 VAL   A CA  1 
ATOM   2782 C  C   . VAL   A 1 358 ? 135.221 147.032 186.936 1.00 108.57 ? 407 VAL   A C   1 
ATOM   2783 O  O   . VAL   A 1 358 ? 134.676 147.876 187.656 1.00 116.18 ? 407 VAL   A O   1 
ATOM   2784 C  CB  . VAL   A 1 358 ? 135.621 147.850 184.578 1.00 103.54 ? 407 VAL   A CB  1 
ATOM   2785 C  CG1 . VAL   A 1 358 ? 134.882 149.165 184.724 1.00 112.22 ? 407 VAL   A CG1 1 
ATOM   2786 C  CG2 . VAL   A 1 358 ? 136.676 147.956 183.495 1.00 113.46 ? 407 VAL   A CG2 1 
ATOM   2787 N  N   . ASN   A 1 359 ? 134.918 145.734 187.023 1.00 105.53 ? 408 ASN   A N   1 
ATOM   2788 C  CA  . ASN   A 1 359 ? 133.907 145.274 187.967 1.00 96.21  ? 408 ASN   A CA  1 
ATOM   2789 C  C   . ASN   A 1 359 ? 134.304 145.520 189.416 1.00 98.69  ? 408 ASN   A C   1 
ATOM   2790 O  O   . ASN   A 1 359 ? 133.436 145.502 190.294 1.00 99.39  ? 408 ASN   A O   1 
ATOM   2791 C  CB  . ASN   A 1 359 ? 133.629 143.786 187.760 1.00 95.68  ? 408 ASN   A CB  1 
ATOM   2792 C  CG  . ASN   A 1 359 ? 132.632 143.529 186.652 1.00 102.21 ? 408 ASN   A CG  1 
ATOM   2793 O  OD1 . ASN   A 1 359 ? 132.719 144.117 185.576 1.00 110.09 ? 408 ASN   A OD1 1 
ATOM   2794 N  ND2 . ASN   A 1 359 ? 131.677 142.646 186.910 1.00 101.20 ? 408 ASN   A ND2 1 
ATOM   2795 N  N   . GLN   A 1 360 ? 135.588 145.752 189.688 1.00 104.39 ? 409 GLN   A N   1 
ATOM   2796 C  CA  . GLN   A 1 360 ? 136.072 145.912 191.050 1.00 108.24 ? 409 GLN   A CA  1 
ATOM   2797 C  C   . GLN   A 1 360 ? 136.517 147.327 191.386 1.00 109.88 ? 409 GLN   A C   1 
ATOM   2798 O  O   . GLN   A 1 360 ? 136.844 147.591 192.548 1.00 109.70 ? 409 GLN   A O   1 
ATOM   2799 C  CB  . GLN   A 1 360 ? 137.231 144.943 191.314 1.00 107.70 ? 409 GLN   A CB  1 
ATOM   2800 C  CG  . GLN   A 1 360 ? 137.142 143.666 190.514 1.00 101.55 ? 409 GLN   A CG  1 
ATOM   2801 C  CD  . GLN   A 1 360 ? 138.253 142.697 190.843 1.00 108.29 ? 409 GLN   A CD  1 
ATOM   2802 O  OE1 . GLN   A 1 360 ? 139.412 142.931 190.511 1.00 111.19 ? 409 GLN   A OE1 1 
ATOM   2803 N  NE2 . GLN   A 1 360 ? 137.903 141.594 191.487 1.00 109.05 ? 409 GLN   A NE2 1 
ATOM   2804 N  N   . ARG   A 1 361 ? 136.552 148.237 190.414 1.00 114.70 ? 410 ARG   A N   1 
ATOM   2805 C  CA  . ARG   A 1 361 ? 136.875 149.633 190.678 1.00 115.89 ? 410 ARG   A CA  1 
ATOM   2806 C  C   . ARG   A 1 361 ? 135.718 150.562 190.325 1.00 120.12 ? 410 ARG   A C   1 
ATOM   2807 O  O   . ARG   A 1 361 ? 135.926 151.764 190.135 1.00 120.39 ? 410 ARG   A O   1 
ATOM   2808 C  CB  . ARG   A 1 361 ? 138.144 150.044 189.930 1.00 115.80 ? 410 ARG   A CB  1 
ATOM   2809 C  CG  . ARG   A 1 361 ? 138.010 150.065 188.421 1.00 117.07 ? 410 ARG   A CG  1 
ATOM   2810 C  CD  . ARG   A 1 361 ? 139.356 150.312 187.771 1.00 121.85 ? 410 ARG   A CD  1 
ATOM   2811 N  NE  . ARG   A 1 361 ? 140.446 149.776 188.577 1.00 120.76 ? 410 ARG   A NE  1 
ATOM   2812 C  CZ  . ARG   A 1 361 ? 141.732 149.929 188.294 1.00 123.87 ? 410 ARG   A CZ  1 
ATOM   2813 N  NH1 . ARG   A 1 361 ? 142.129 150.600 187.225 1.00 123.96 ? 410 ARG   A NH1 1 
ATOM   2814 N  NH2 . ARG   A 1 361 ? 142.642 149.396 189.103 1.00 124.40 ? 410 ARG   A NH2 1 
ATOM   2815 N  N   . LEU   A 1 362 ? 134.504 150.029 190.229 1.00 126.70 ? 411 LEU   A N   1 
ATOM   2816 C  CA  . LEU   A 1 362 ? 133.337 150.863 189.980 1.00 127.02 ? 411 LEU   A CA  1 
ATOM   2817 C  C   . LEU   A 1 362 ? 133.012 151.684 191.221 1.00 133.23 ? 411 LEU   A C   1 
ATOM   2818 O  O   . LEU   A 1 362 ? 132.959 151.152 192.334 1.00 133.10 ? 411 LEU   A O   1 
ATOM   2819 C  CB  . LEU   A 1 362 ? 132.140 150.000 189.589 1.00 127.20 ? 411 LEU   A CB  1 
ATOM   2820 C  CG  . LEU   A 1 362 ? 131.987 149.656 188.107 1.00 128.17 ? 411 LEU   A CG  1 
ATOM   2821 C  CD1 . LEU   A 1 362 ? 130.570 149.197 187.813 1.00 128.16 ? 411 LEU   A CD1 1 
ATOM   2822 C  CD2 . LEU   A 1 362 ? 132.362 150.842 187.236 1.00 127.40 ? 411 LEU   A CD2 1 
ATOM   2823 N  N   . LYS   A 1 363 ? 132.787 152.984 191.028 1.00 140.66 ? 412 LYS   A N   1 
ATOM   2824 C  CA  . LYS   A 1 363 ? 132.488 153.875 192.141 1.00 136.90 ? 412 LYS   A CA  1 
ATOM   2825 C  C   . LYS   A 1 363 ? 131.088 153.678 192.704 1.00 135.24 ? 412 LYS   A C   1 
ATOM   2826 O  O   . LYS   A 1 363 ? 130.773 154.258 193.749 1.00 136.59 ? 412 LYS   A O   1 
ATOM   2827 C  CB  . LYS   A 1 363 ? 132.668 155.333 191.712 1.00 135.39 ? 412 LYS   A CB  1 
ATOM   2828 C  CG  . LYS   A 1 363 ? 131.489 155.908 190.945 1.00 139.74 ? 412 LYS   A CG  1 
ATOM   2829 C  CD  . LYS   A 1 363 ? 131.622 157.414 190.783 1.00 140.23 ? 412 LYS   A CD  1 
ATOM   2830 C  CE  . LYS   A 1 363 ? 132.915 157.782 190.073 1.00 140.02 ? 412 LYS   A CE  1 
ATOM   2831 N  NZ  . LYS   A 1 363 ? 132.791 157.679 188.593 1.00 140.04 ? 412 LYS   A NZ  1 
ATOM   2832 N  N   . ASP   A 1 364 ? 130.244 152.885 192.040 1.00 143.52 ? 413 ASP   A N   1 
ATOM   2833 C  CA  . ASP   A 1 364 ? 128.893 152.655 192.541 1.00 145.89 ? 413 ASP   A CA  1 
ATOM   2834 C  C   . ASP   A 1 364 ? 128.914 151.924 193.877 1.00 145.11 ? 413 ASP   A C   1 
ATOM   2835 O  O   . ASP   A 1 364 ? 128.118 152.228 194.773 1.00 146.46 ? 413 ASP   A O   1 
ATOM   2836 C  CB  . ASP   A 1 364 ? 128.080 151.870 191.514 1.00 147.36 ? 413 ASP   A CB  1 
ATOM   2837 C  CG  . ASP   A 1 364 ? 128.034 152.555 190.164 1.00 150.08 ? 413 ASP   A CG  1 
ATOM   2838 O  OD1 . ASP   A 1 364 ? 128.594 153.664 190.040 1.00 149.02 ? 413 ASP   A OD1 1 
ATOM   2839 O  OD2 . ASP   A 1 364 ? 127.439 151.984 189.226 1.00 151.64 ? 413 ASP   A OD2 1 
ATOM   2840 N  N   . SER   A 1 365 ? 129.813 150.954 194.030 1.00 142.62 ? 414 SER   A N   1 
ATOM   2841 C  CA  . SER   A 1 365 ? 129.901 150.165 195.250 1.00 144.16 ? 414 SER   A CA  1 
ATOM   2842 C  C   . SER   A 1 365 ? 131.278 150.172 195.894 1.00 146.07 ? 414 SER   A C   1 
ATOM   2843 O  O   . SER   A 1 365 ? 131.366 150.067 197.119 1.00 146.79 ? 414 SER   A O   1 
ATOM   2844 C  CB  . SER   A 1 365 ? 129.494 148.710 194.975 1.00 143.54 ? 414 SER   A CB  1 
ATOM   2845 O  OG  . SER   A 1 365 ? 130.094 148.231 193.784 1.00 145.13 ? 414 SER   A OG  1 
ATOM   2846 N  N   . TRP   A 1 366 ? 132.348 150.294 195.114 1.00 135.33 ? 415 TRP   A N   1 
ATOM   2847 C  CA  . TRP   A 1 366 ? 133.708 150.277 195.650 1.00 131.89 ? 415 TRP   A CA  1 
ATOM   2848 C  C   . TRP   A 1 366 ? 134.109 151.705 195.995 1.00 133.74 ? 415 TRP   A C   1 
ATOM   2849 O  O   . TRP   A 1 366 ? 134.591 152.453 195.141 1.00 137.21 ? 415 TRP   A O   1 
ATOM   2850 C  CB  . TRP   A 1 366 ? 134.675 149.654 194.650 1.00 131.40 ? 415 TRP   A CB  1 
ATOM   2851 C  CG  . TRP   A 1 366 ? 134.502 148.177 194.487 1.00 131.49 ? 415 TRP   A CG  1 
ATOM   2852 C  CD1 . TRP   A 1 366 ? 133.876 147.533 193.461 1.00 133.25 ? 415 TRP   A CD1 1 
ATOM   2853 C  CD2 . TRP   A 1 366 ? 134.954 147.156 195.384 1.00 133.48 ? 415 TRP   A CD2 1 
ATOM   2854 N  NE1 . TRP   A 1 366 ? 133.915 146.175 193.660 1.00 134.64 ? 415 TRP   A NE1 1 
ATOM   2855 C  CE2 . TRP   A 1 366 ? 134.571 145.918 194.835 1.00 133.54 ? 415 TRP   A CE2 1 
ATOM   2856 C  CE3 . TRP   A 1 366 ? 135.647 147.169 196.598 1.00 133.38 ? 415 TRP   A CE3 1 
ATOM   2857 C  CZ2 . TRP   A 1 366 ? 134.857 144.707 195.456 1.00 133.45 ? 415 TRP   A CZ2 1 
ATOM   2858 C  CZ3 . TRP   A 1 366 ? 135.929 145.966 197.213 1.00 134.72 ? 415 TRP   A CZ3 1 
ATOM   2859 C  CH2 . TRP   A 1 366 ? 135.536 144.751 196.641 1.00 133.91 ? 415 TRP   A CH2 1 
ATOM   2860 N  N   . VAL   A 1 367 ? 133.913 152.086 197.258 1.00 137.61 ? 416 VAL   A N   1 
ATOM   2861 C  CA  . VAL   A 1 367 ? 134.297 153.418 197.705 1.00 141.63 ? 416 VAL   A CA  1 
ATOM   2862 C  C   . VAL   A 1 367 ? 135.820 153.507 197.782 1.00 143.24 ? 416 VAL   A C   1 
ATOM   2863 O  O   . VAL   A 1 367 ? 136.511 152.507 198.021 1.00 143.45 ? 416 VAL   A O   1 
ATOM   2864 C  CB  . VAL   A 1 367 ? 133.619 153.733 199.053 1.00 140.29 ? 416 VAL   A CB  1 
ATOM   2865 C  CG1 . VAL   A 1 367 ? 134.257 152.941 200.192 1.00 138.86 ? 416 VAL   A CG1 1 
ATOM   2866 C  CG2 . VAL   A 1 367 ? 133.609 155.231 199.326 1.00 140.17 ? 416 VAL   A CG2 1 
ATOM   2867 N  N   . GLU   A 1 368 ? 136.349 154.714 197.567 1.00 147.94 ? 417 GLU   A N   1 
ATOM   2868 C  CA  . GLU   A 1 368 ? 137.763 154.948 197.239 1.00 148.91 ? 417 GLU   A CA  1 
ATOM   2869 C  C   . GLU   A 1 368 ? 138.275 153.867 196.285 1.00 148.50 ? 417 GLU   A C   1 
ATOM   2870 O  O   . GLU   A 1 368 ? 139.164 153.076 196.602 1.00 149.21 ? 417 GLU   A O   1 
ATOM   2871 C  CB  . GLU   A 1 368 ? 138.675 155.084 198.471 1.00 150.02 ? 417 GLU   A CB  1 
ATOM   2872 C  CG  . GLU   A 1 368 ? 138.599 154.037 199.575 1.00 150.94 ? 417 GLU   A CG  1 
ATOM   2873 C  CD  . GLU   A 1 368 ? 137.431 154.251 200.510 1.00 151.13 ? 417 GLU   A CD  1 
ATOM   2874 O  OE1 . GLU   A 1 368 ? 137.443 153.677 201.619 1.00 151.07 ? 417 GLU   A OE1 1 
ATOM   2875 O  OE2 . GLU   A 1 368 ? 136.542 155.055 200.174 1.00 148.23 ? 417 GLU   A OE2 1 
ATOM   2876 N  N   . ARG   A 1 369 ? 137.671 153.854 195.093 1.00 131.18 ? 418 ARG   A N   1 
ATOM   2877 C  CA  . ARG   A 1 369 ? 137.877 152.769 194.137 1.00 129.61 ? 418 ARG   A CA  1 
ATOM   2878 C  C   . ARG   A 1 369 ? 139.351 152.536 193.829 1.00 132.86 ? 418 ARG   A C   1 
ATOM   2879 O  O   . ARG   A 1 369 ? 139.812 151.390 193.798 1.00 137.12 ? 418 ARG   A O   1 
ATOM   2880 C  CB  . ARG   A 1 369 ? 137.108 153.071 192.851 1.00 132.48 ? 418 ARG   A CB  1 
ATOM   2881 C  CG  . ARG   A 1 369 ? 137.106 154.544 192.476 1.00 131.29 ? 418 ARG   A CG  1 
ATOM   2882 C  CD  . ARG   A 1 369 ? 136.247 154.810 191.253 1.00 132.67 ? 418 ARG   A CD  1 
ATOM   2883 N  NE  . ARG   A 1 369 ? 136.929 154.451 190.015 1.00 132.69 ? 418 ARG   A NE  1 
ATOM   2884 C  CZ  . ARG   A 1 369 ? 137.813 155.222 189.398 1.00 131.38 ? 418 ARG   A CZ  1 
ATOM   2885 N  NH1 . ARG   A 1 369 ? 138.155 156.405 189.880 1.00 131.22 ? 418 ARG   A NH1 1 
ATOM   2886 N  NH2 . ARG   A 1 369 ? 138.370 154.793 188.268 1.00 133.55 ? 418 ARG   A NH2 1 
ATOM   2887 N  N   . LEU   A 1 370 ? 140.109 153.605 193.603 1.00 138.82 ? 419 LEU   A N   1 
ATOM   2888 C  CA  . LEU   A 1 370 ? 141.504 153.489 193.200 1.00 139.55 ? 419 LEU   A CA  1 
ATOM   2889 C  C   . LEU   A 1 370 ? 142.471 153.556 194.375 1.00 140.16 ? 419 LEU   A C   1 
ATOM   2890 O  O   . LEU   A 1 370 ? 143.685 153.620 194.161 1.00 140.26 ? 419 LEU   A O   1 
ATOM   2891 C  CB  . LEU   A 1 370 ? 141.851 154.574 192.179 1.00 141.51 ? 419 LEU   A CB  1 
ATOM   2892 C  CG  . LEU   A 1 370 ? 141.313 154.379 190.760 1.00 140.91 ? 419 LEU   A CG  1 
ATOM   2893 C  CD1 . LEU   A 1 370 ? 142.184 155.114 189.754 1.00 141.24 ? 419 LEU   A CD1 1 
ATOM   2894 C  CD2 . LEU   A 1 370 ? 141.223 152.903 190.414 1.00 135.39 ? 419 LEU   A CD2 1 
ATOM   2895 N  N   . ASP   A 1 371 ? 141.969 153.541 195.605 1.00 146.26 ? 420 ASP   A N   1 
ATOM   2896 C  CA  . ASP   A 1 371 ? 142.808 153.637 196.791 1.00 148.72 ? 420 ASP   A CA  1 
ATOM   2897 C  C   . ASP   A 1 371 ? 143.117 152.241 197.313 1.00 148.85 ? 420 ASP   A C   1 
ATOM   2898 O  O   . ASP   A 1 371 ? 142.207 151.428 197.505 1.00 144.61 ? 420 ASP   A O   1 
ATOM   2899 C  CB  . ASP   A 1 371 ? 142.121 154.470 197.874 1.00 148.06 ? 420 ASP   A CB  1 
ATOM   2900 C  CG  . ASP   A 1 371 ? 142.876 154.461 199.189 1.00 151.29 ? 420 ASP   A CG  1 
ATOM   2901 O  OD1 . ASP   A 1 371 ? 144.114 154.297 199.172 1.00 152.57 ? 420 ASP   A OD1 1 
ATOM   2902 O  OD2 . ASP   A 1 371 ? 142.227 154.620 200.245 1.00 149.98 ? 420 ASP   A OD2 1 
ATOM   2903 N  N   . PHE   A 1 372 ? 144.400 151.970 197.545 1.00 133.80 ? 421 PHE   A N   1 
ATOM   2904 C  CA  . PHE   A 1 372 ? 144.837 150.680 198.067 1.00 131.68 ? 421 PHE   A CA  1 
ATOM   2905 C  C   . PHE   A 1 372 ? 144.667 150.677 199.580 1.00 133.95 ? 421 PHE   A C   1 
ATOM   2906 O  O   . PHE   A 1 372 ? 145.370 151.399 200.293 1.00 134.78 ? 421 PHE   A O   1 
ATOM   2907 C  CB  . PHE   A 1 372 ? 146.287 150.411 197.673 1.00 130.40 ? 421 PHE   A CB  1 
ATOM   2908 C  CG  . PHE   A 1 372 ? 146.825 149.106 198.188 1.00 136.40 ? 421 PHE   A CG  1 
ATOM   2909 C  CD1 . PHE   A 1 372 ? 146.664 147.942 197.460 1.00 132.20 ? 421 PHE   A CD1 1 
ATOM   2910 C  CD2 . PHE   A 1 372 ? 147.503 149.047 199.394 1.00 137.38 ? 421 PHE   A CD2 1 
ATOM   2911 C  CE1 . PHE   A 1 372 ? 147.158 146.743 197.929 1.00 131.01 ? 421 PHE   A CE1 1 
ATOM   2912 C  CE2 . PHE   A 1 372 ? 148.000 147.851 199.867 1.00 131.15 ? 421 PHE   A CE2 1 
ATOM   2913 C  CZ  . PHE   A 1 372 ? 147.827 146.698 199.133 1.00 129.64 ? 421 PHE   A CZ  1 
ATOM   2914 N  N   . ASN   A 1 373 ? 143.736 149.863 200.073 1.00 138.34 ? 422 ASN   A N   1 
ATOM   2915 C  CA  . ASN   A 1 373 ? 143.472 149.771 201.508 1.00 138.12 ? 422 ASN   A CA  1 
ATOM   2916 C  C   . ASN   A 1 373 ? 142.992 148.366 201.825 1.00 140.33 ? 422 ASN   A C   1 
ATOM   2917 O  O   . ASN   A 1 373 ? 141.799 148.058 201.709 1.00 141.46 ? 422 ASN   A O   1 
ATOM   2918 C  CB  . ASN   A 1 373 ? 142.445 150.808 201.959 1.00 140.91 ? 422 ASN   A CB  1 
ATOM   2919 C  CG  . ASN   A 1 373 ? 142.288 150.854 203.465 1.00 142.65 ? 422 ASN   A CG  1 
ATOM   2920 O  OD1 . ASN   A 1 373 ? 143.267 150.773 204.206 1.00 141.96 ? 422 ASN   A OD1 1 
ATOM   2921 N  ND2 . ASN   A 1 373 ? 141.049 150.985 203.926 1.00 142.23 ? 422 ASN   A ND2 1 
ATOM   2922 N  N   . PRO   A 1 374 ? 143.902 147.475 202.237 1.00 144.29 ? 423 PRO   A N   1 
ATOM   2923 C  CA  . PRO   A 1 374 ? 143.529 146.107 202.620 1.00 144.75 ? 423 PRO   A CA  1 
ATOM   2924 C  C   . PRO   A 1 374 ? 142.895 146.022 204.006 1.00 146.72 ? 423 PRO   A C   1 
ATOM   2925 O  O   . PRO   A 1 374 ? 143.219 145.142 204.806 1.00 148.65 ? 423 PRO   A O   1 
ATOM   2926 C  CB  . PRO   A 1 374 ? 144.867 145.364 202.561 1.00 147.82 ? 423 PRO   A CB  1 
ATOM   2927 C  CG  . PRO   A 1 374 ? 145.876 146.407 202.860 1.00 146.95 ? 423 PRO   A CG  1 
ATOM   2928 C  CD  . PRO   A 1 374 ? 145.360 147.666 202.227 1.00 145.60 ? 423 PRO   A CD  1 
ATOM   2929 N  N   . ASP   A 1 375 ? 141.981 146.947 204.288 1.00 151.49 ? 424 ASP   A N   1 
ATOM   2930 C  CA  . ASP   A 1 375 ? 141.146 146.897 205.476 1.00 152.22 ? 424 ASP   A CA  1 
ATOM   2931 C  C   . ASP   A 1 375 ? 139.671 147.014 205.130 1.00 152.42 ? 424 ASP   A C   1 
ATOM   2932 O  O   . ASP   A 1 375 ? 138.831 146.975 206.035 1.00 155.14 ? 424 ASP   A O   1 
ATOM   2933 C  CB  . ASP   A 1 375 ? 141.533 148.009 206.462 1.00 153.66 ? 424 ASP   A CB  1 
ATOM   2934 C  CG  . ASP   A 1 375 ? 142.845 147.730 207.171 1.00 154.89 ? 424 ASP   A CG  1 
ATOM   2935 O  OD1 . ASP   A 1 375 ? 143.250 146.551 207.237 1.00 155.66 ? 424 ASP   A OD1 1 
ATOM   2936 O  OD2 . ASP   A 1 375 ? 143.473 148.692 207.662 1.00 152.76 ? 424 ASP   A OD2 1 
ATOM   2937 N  N   . ARG   A 1 376 ? 139.338 147.160 203.846 1.00 144.63 ? 425 ARG   A N   1 
ATOM   2938 C  CA  . ARG   A 1 376 ? 137.943 147.263 203.435 1.00 148.33 ? 425 ARG   A CA  1 
ATOM   2939 C  C   . ARG   A 1 376 ? 137.186 145.976 203.733 1.00 149.14 ? 425 ARG   A C   1 
ATOM   2940 O  O   . ARG   A 1 376 ? 136.023 146.012 204.153 1.00 145.00 ? 425 ARG   A O   1 
ATOM   2941 C  CB  . ARG   A 1 376 ? 137.876 147.598 201.946 1.00 143.98 ? 425 ARG   A CB  1 
ATOM   2942 C  CG  . ARG   A 1 376 ? 136.507 148.001 201.444 1.00 147.71 ? 425 ARG   A CG  1 
ATOM   2943 C  CD  . ARG   A 1 376 ? 136.626 148.765 200.137 1.00 149.55 ? 425 ARG   A CD  1 
ATOM   2944 N  NE  . ARG   A 1 376 ? 137.974 148.688 199.588 1.00 146.15 ? 425 ARG   A NE  1 
ATOM   2945 C  CZ  . ARG   A 1 376 ? 138.578 149.675 198.941 1.00 144.03 ? 425 ARG   A CZ  1 
ATOM   2946 N  NH1 . ARG   A 1 376 ? 137.983 150.839 198.744 1.00 144.64 ? 425 ARG   A NH1 1 
ATOM   2947 N  NH2 . ARG   A 1 376 ? 139.812 149.489 198.480 1.00 140.24 ? 425 ARG   A NH2 1 
ATOM   2948 N  N   . TYR   A 1 377 ? 137.830 144.827 203.523 1.00 149.80 ? 426 TYR   A N   1 
ATOM   2949 C  CA  . TYR   A 1 377 ? 137.185 143.545 203.779 1.00 149.12 ? 426 TYR   A CA  1 
ATOM   2950 C  C   . TYR   A 1 377 ? 137.025 143.254 205.263 1.00 149.62 ? 426 TYR   A C   1 
ATOM   2951 O  O   . TYR   A 1 377 ? 136.285 142.331 205.621 1.00 149.01 ? 426 TYR   A O   1 
ATOM   2952 C  CB  . TYR   A 1 377 ? 137.967 142.426 203.094 1.00 146.66 ? 426 TYR   A CB  1 
ATOM   2953 C  CG  . TYR   A 1 377 ? 138.587 142.863 201.791 1.00 146.00 ? 426 TYR   A CG  1 
ATOM   2954 C  CD1 . TYR   A 1 377 ? 137.817 142.962 200.641 1.00 148.41 ? 426 TYR   A CD1 1 
ATOM   2955 C  CD2 . TYR   A 1 377 ? 139.932 143.191 201.709 1.00 145.89 ? 426 TYR   A CD2 1 
ATOM   2956 C  CE1 . TYR   A 1 377 ? 138.367 143.366 199.448 1.00 149.23 ? 426 TYR   A CE1 1 
ATOM   2957 C  CE2 . TYR   A 1 377 ? 140.492 143.597 200.516 1.00 147.73 ? 426 TYR   A CE2 1 
ATOM   2958 C  CZ  . TYR   A 1 377 ? 139.703 143.682 199.389 1.00 150.69 ? 426 TYR   A CZ  1 
ATOM   2959 O  OH  . TYR   A 1 377 ? 140.249 144.086 198.196 1.00 151.10 ? 426 TYR   A OH  1 
ATOM   2960 N  N   . LEU   A 1 378 ? 137.699 144.007 206.133 1.00 152.95 ? 427 LEU   A N   1 
ATOM   2961 C  CA  . LEU   A 1 378 ? 137.423 143.892 207.560 1.00 153.35 ? 427 LEU   A CA  1 
ATOM   2962 C  C   . LEU   A 1 378 ? 135.998 144.333 207.871 1.00 152.80 ? 427 LEU   A C   1 
ATOM   2963 O  O   . LEU   A 1 378 ? 135.314 143.717 208.696 1.00 151.44 ? 427 LEU   A O   1 
ATOM   2964 C  CB  . LEU   A 1 378 ? 138.432 144.711 208.362 1.00 151.21 ? 427 LEU   A CB  1 
ATOM   2965 C  CG  . LEU   A 1 378 ? 139.601 143.927 208.958 1.00 152.69 ? 427 LEU   A CG  1 
ATOM   2966 C  CD1 . LEU   A 1 378 ? 140.489 144.837 209.791 1.00 149.41 ? 427 LEU   A CD1 1 
ATOM   2967 C  CD2 . LEU   A 1 378 ? 139.092 142.760 209.788 1.00 153.29 ? 427 LEU   A CD2 1 
ATOM   2968 N  N   . GLN   A 1 379 ? 135.535 145.396 207.218 1.00 160.52 ? 428 GLN   A N   1 
ATOM   2969 C  CA  . GLN   A 1 379 ? 134.158 145.842 207.335 1.00 163.28 ? 428 GLN   A CA  1 
ATOM   2970 C  C   . GLN   A 1 379 ? 133.340 145.308 206.160 1.00 166.02 ? 428 GLN   A C   1 
ATOM   2971 O  O   . GLN   A 1 379 ? 133.825 144.533 205.332 1.00 163.92 ? 428 GLN   A O   1 
ATOM   2972 C  CB  . GLN   A 1 379 ? 134.093 147.368 207.400 1.00 162.38 ? 428 GLN   A CB  1 
ATOM   2973 C  CG  . GLN   A 1 379 ? 134.615 147.961 208.697 1.00 163.63 ? 428 GLN   A CG  1 
ATOM   2974 C  CD  . GLN   A 1 379 ? 136.100 148.260 208.644 1.00 164.74 ? 428 GLN   A CD  1 
ATOM   2975 O  OE1 . GLN   A 1 379 ? 136.877 147.500 208.068 1.00 163.98 ? 428 GLN   A OE1 1 
ATOM   2976 N  NE2 . GLN   A 1 379 ? 136.502 149.373 209.246 1.00 164.97 ? 428 GLN   A NE2 1 
ATOM   2977 N  N   . ASP   A 1 380 ? 132.079 145.726 206.088 1.00 173.45 ? 429 ASP   A N   1 
ATOM   2978 C  CA  . ASP   A 1 380 ? 131.226 145.333 204.975 1.00 172.15 ? 429 ASP   A CA  1 
ATOM   2979 C  C   . ASP   A 1 380 ? 131.709 145.989 203.688 1.00 172.42 ? 429 ASP   A C   1 
ATOM   2980 O  O   . ASP   A 1 380 ? 132.064 147.171 203.669 1.00 173.15 ? 429 ASP   A O   1 
ATOM   2981 C  CB  . ASP   A 1 380 ? 129.775 145.721 205.255 1.00 169.99 ? 429 ASP   A CB  1 
ATOM   2982 C  CG  . ASP   A 1 380 ? 128.833 145.297 204.145 1.00 171.87 ? 429 ASP   A CG  1 
ATOM   2983 O  OD1 . ASP   A 1 380 ? 129.206 144.410 203.348 1.00 169.69 ? 429 ASP   A OD1 1 
ATOM   2984 O  OD2 . ASP   A 1 380 ? 127.717 145.853 204.069 1.00 173.13 ? 429 ASP   A OD2 1 
ATOM   2985 N  N   . ASN   A 1 381 ? 131.721 145.216 202.606 1.00 157.25 ? 430 ASN   A N   1 
ATOM   2986 C  CA  . ASN   A 1 381 ? 132.282 145.678 201.346 1.00 156.85 ? 430 ASN   A CA  1 
ATOM   2987 C  C   . ASN   A 1 381 ? 131.693 144.834 200.222 1.00 155.45 ? 430 ASN   A C   1 
ATOM   2988 O  O   . ASN   A 1 381 ? 131.123 143.767 200.480 1.00 154.65 ? 430 ASN   A O   1 
ATOM   2989 C  CB  . ASN   A 1 381 ? 133.817 145.586 201.360 1.00 158.80 ? 430 ASN   A CB  1 
ATOM   2990 C  CG  . ASN   A 1 381 ? 134.323 144.220 200.965 1.00 159.29 ? 430 ASN   A CG  1 
ATOM   2991 O  OD1 . ASN   A 1 381 ? 134.519 143.946 199.784 1.00 155.48 ? 430 ASN   A OD1 1 
ATOM   2992 N  ND2 . ASN   A 1 381 ? 134.521 143.349 201.946 1.00 158.30 ? 430 ASN   A ND2 1 
ATOM   2993 N  N   . PRO   A 1 382 ? 131.801 145.290 198.969 1.00 136.83 ? 431 PRO   A N   1 
ATOM   2994 C  CA  . PRO   A 1 382 ? 131.153 144.558 197.868 1.00 134.76 ? 431 PRO   A CA  1 
ATOM   2995 C  C   . PRO   A 1 382 ? 131.615 143.119 197.701 1.00 142.87 ? 431 PRO   A C   1 
ATOM   2996 O  O   . PRO   A 1 382 ? 130.818 142.290 197.246 1.00 145.42 ? 431 PRO   A O   1 
ATOM   2997 C  CB  . PRO   A 1 382 ? 131.506 145.404 196.638 1.00 135.81 ? 431 PRO   A CB  1 
ATOM   2998 C  CG  . PRO   A 1 382 ? 131.684 146.769 197.176 1.00 139.30 ? 431 PRO   A CG  1 
ATOM   2999 C  CD  . PRO   A 1 382 ? 132.329 146.589 198.517 1.00 138.19 ? 431 PRO   A CD  1 
ATOM   3000 N  N   . ALA   A 1 383 ? 132.863 142.790 198.056 1.00 148.99 ? 432 ALA   A N   1 
ATOM   3001 C  CA  . ALA   A 1 383 ? 133.358 141.432 197.838 1.00 147.12 ? 432 ALA   A CA  1 
ATOM   3002 C  C   . ALA   A 1 383 ? 132.492 140.393 198.535 1.00 143.19 ? 432 ALA   A C   1 
ATOM   3003 O  O   . ALA   A 1 383 ? 132.407 139.248 198.076 1.00 140.87 ? 432 ALA   A O   1 
ATOM   3004 C  CB  . ALA   A 1 383 ? 134.807 141.305 198.309 1.00 145.55 ? 432 ALA   A CB  1 
ATOM   3005 N  N   . SER   A 1 384 ? 131.848 140.766 199.638 1.00 149.71 ? 433 SER   A N   1 
ATOM   3006 C  CA  . SER   A 1 384 ? 130.884 139.902 200.302 1.00 150.19 ? 433 SER   A CA  1 
ATOM   3007 C  C   . SER   A 1 384 ? 129.443 140.342 200.106 1.00 151.64 ? 433 SER   A C   1 
ATOM   3008 O  O   . SER   A 1 384 ? 128.551 139.492 200.083 1.00 149.16 ? 433 SER   A O   1 
ATOM   3009 C  CB  . SER   A 1 384 ? 131.182 139.829 201.805 1.00 149.74 ? 433 SER   A CB  1 
ATOM   3010 O  OG  . SER   A 1 384 ? 131.467 141.114 202.328 1.00 154.64 ? 433 SER   A OG  1 
ATOM   3011 N  N   . GLY   A 1 385 ? 129.196 141.646 199.968 1.00 163.51 ? 434 GLY   A N   1 
ATOM   3012 C  CA  . GLY   A 1 385 ? 127.832 142.115 199.789 1.00 163.06 ? 434 GLY   A CA  1 
ATOM   3013 C  C   . GLY   A 1 385 ? 127.216 141.688 198.470 1.00 165.66 ? 434 GLY   A C   1 
ATOM   3014 O  O   . GLY   A 1 385 ? 126.064 141.248 198.428 1.00 167.90 ? 434 GLY   A O   1 
ATOM   3015 N  N   . GLU   A 1 386 ? 127.967 141.807 197.379 1.00 151.69 ? 435 GLU   A N   1 
ATOM   3016 C  CA  . GLU   A 1 386 ? 127.455 141.546 196.043 1.00 148.43 ? 435 GLU   A CA  1 
ATOM   3017 C  C   . GLU   A 1 386 ? 128.020 140.238 195.505 1.00 145.71 ? 435 GLU   A C   1 
ATOM   3018 O  O   . GLU   A 1 386 ? 129.126 139.824 195.861 1.00 145.61 ? 435 GLU   A O   1 
ATOM   3019 C  CB  . GLU   A 1 386 ? 127.794 142.697 195.092 1.00 145.97 ? 435 GLU   A CB  1 
ATOM   3020 C  CG  . GLU   A 1 386 ? 126.867 143.894 195.230 1.00 147.08 ? 435 GLU   A CG  1 
ATOM   3021 C  CD  . GLU   A 1 386 ? 127.305 145.077 194.390 1.00 153.85 ? 435 GLU   A CD  1 
ATOM   3022 O  OE1 . GLU   A 1 386 ? 128.232 144.917 193.570 1.00 154.26 ? 435 GLU   A OE1 1 
ATOM   3023 O  OE2 . GLU   A 1 386 ? 126.723 146.170 194.552 1.00 154.22 ? 435 GLU   A OE2 1 
ATOM   3024 N  N   . LYS   A 1 387 ? 127.237 139.590 194.640 1.00 132.69 ? 436 LYS   A N   1 
ATOM   3025 C  CA  . LYS   A 1 387 ? 127.600 138.262 194.157 1.00 137.42 ? 436 LYS   A CA  1 
ATOM   3026 C  C   . LYS   A 1 387 ? 128.851 138.302 193.287 1.00 134.02 ? 436 LYS   A C   1 
ATOM   3027 O  O   . LYS   A 1 387 ? 129.799 137.542 193.514 1.00 132.59 ? 436 LYS   A O   1 
ATOM   3028 C  CB  . LYS   A 1 387 ? 126.428 137.653 193.385 1.00 136.99 ? 436 LYS   A CB  1 
ATOM   3029 C  CG  . LYS   A 1 387 ? 126.206 136.175 193.654 1.00 137.03 ? 436 LYS   A CG  1 
ATOM   3030 C  CD  . LYS   A 1 387 ? 124.740 135.807 193.507 1.00 136.72 ? 436 LYS   A CD  1 
ATOM   3031 C  CE  . LYS   A 1 387 ? 124.556 134.305 193.380 1.00 136.95 ? 436 LYS   A CE  1 
ATOM   3032 N  NZ  . LYS   A 1 387 ? 123.127 133.909 193.511 1.00 135.58 ? 436 LYS   A NZ  1 
ATOM   3033 N  N   . PHE   A 1 388 ? 128.878 139.185 192.292 1.00 118.34 ? 437 PHE   A N   1 
ATOM   3034 C  CA  . PHE   A 1 388 ? 129.945 139.203 191.299 1.00 114.26 ? 437 PHE   A CA  1 
ATOM   3035 C  C   . PHE   A 1 388 ? 130.553 140.590 191.174 1.00 119.25 ? 437 PHE   A C   1 
ATOM   3036 O  O   . PHE   A 1 388 ? 130.778 141.093 190.069 1.00 118.26 ? 437 PHE   A O   1 
ATOM   3037 C  CB  . PHE   A 1 388 ? 129.437 138.717 189.945 1.00 112.25 ? 437 PHE   A CB  1 
ATOM   3038 C  CG  . PHE   A 1 388 ? 128.725 137.398 190.005 1.00 112.57 ? 437 PHE   A CG  1 
ATOM   3039 C  CD1 . PHE   A 1 388 ? 129.306 136.312 190.631 1.00 119.60 ? 437 PHE   A CD1 1 
ATOM   3040 C  CD2 . PHE   A 1 388 ? 127.473 137.246 189.440 1.00 114.83 ? 437 PHE   A CD2 1 
ATOM   3041 C  CE1 . PHE   A 1 388 ? 128.652 135.097 190.690 1.00 125.95 ? 437 PHE   A CE1 1 
ATOM   3042 C  CE2 . PHE   A 1 388 ? 126.815 136.035 189.494 1.00 117.38 ? 437 PHE   A CE2 1 
ATOM   3043 C  CZ  . PHE   A 1 388 ? 127.406 134.959 190.120 1.00 124.90 ? 437 PHE   A CZ  1 
ATOM   3044 N  N   . ALA   A 1 389 ? 130.829 141.234 192.305 1.00 118.63 ? 438 ALA   A N   1 
ATOM   3045 C  CA  . ALA   A 1 389 ? 131.518 142.517 192.293 1.00 115.46 ? 438 ALA   A CA  1 
ATOM   3046 C  C   . ALA   A 1 389 ? 133.030 142.350 192.337 1.00 114.87 ? 438 ALA   A C   1 
ATOM   3047 O  O   . ALA   A 1 389 ? 133.753 143.047 191.618 1.00 123.41 ? 438 ALA   A O   1 
ATOM   3048 C  CB  . ALA   A 1 389 ? 131.056 143.377 193.469 1.00 119.27 ? 438 ALA   A CB  1 
ATOM   3049 N  N   . TYR   A 1 390 ? 133.518 141.437 193.169 1.00 109.70 ? 439 TYR   A N   1 
ATOM   3050 C  CA  . TYR   A 1 390 ? 134.941 141.136 193.296 1.00 112.12 ? 439 TYR   A CA  1 
ATOM   3051 C  C   . TYR   A 1 390 ? 135.175 139.759 192.683 1.00 115.81 ? 439 TYR   A C   1 
ATOM   3052 O  O   . TYR   A 1 390 ? 134.957 138.734 193.335 1.00 121.11 ? 439 TYR   A O   1 
ATOM   3053 C  CB  . TYR   A 1 390 ? 135.370 141.183 194.758 1.00 112.42 ? 439 TYR   A CB  1 
ATOM   3054 C  CG  . TYR   A 1 390 ? 136.785 140.722 195.007 1.00 109.75 ? 439 TYR   A CG  1 
ATOM   3055 C  CD1 . TYR   A 1 390 ? 137.867 141.493 194.615 1.00 107.00 ? 439 TYR   A CD1 1 
ATOM   3056 C  CD2 . TYR   A 1 390 ? 137.037 139.513 195.638 1.00 117.34 ? 439 TYR   A CD2 1 
ATOM   3057 C  CE1 . TYR   A 1 390 ? 139.160 141.072 194.841 1.00 111.54 ? 439 TYR   A CE1 1 
ATOM   3058 C  CE2 . TYR   A 1 390 ? 138.326 139.085 195.869 1.00 114.12 ? 439 TYR   A CE2 1 
ATOM   3059 C  CZ  . TYR   A 1 390 ? 139.382 139.869 195.470 1.00 113.86 ? 439 TYR   A CZ  1 
ATOM   3060 O  OH  . TYR   A 1 390 ? 140.669 139.446 195.696 1.00 120.56 ? 439 TYR   A OH  1 
ATOM   3061 N  N   . VAL   A 1 391 ? 135.618 139.737 191.430 1.00 102.04 ? 440 VAL   A N   1 
ATOM   3062 C  CA  . VAL   A 1 391 ? 135.795 138.485 190.699 1.00 102.05 ? 440 VAL   A CA  1 
ATOM   3063 C  C   . VAL   A 1 391 ? 137.175 138.440 190.051 1.00 109.59 ? 440 VAL   A C   1 
ATOM   3064 O  O   . VAL   A 1 391 ? 137.277 138.468 188.817 1.00 119.25 ? 440 VAL   A O   1 
ATOM   3065 C  CB  . VAL   A 1 391 ? 134.689 138.305 189.648 1.00 101.87 ? 440 VAL   A CB  1 
ATOM   3066 C  CG1 . VAL   A 1 391 ? 133.419 137.826 190.310 1.00 104.99 ? 440 VAL   A CG1 1 
ATOM   3067 C  CG2 . VAL   A 1 391 ? 134.429 139.613 188.919 1.00 97.50  ? 440 VAL   A CG2 1 
ATOM   3068 N  N   . PRO   A 1 392 ? 138.257 138.351 190.822 1.00 111.29 ? 441 PRO   A N   1 
ATOM   3069 C  CA  . PRO   A 1 392 ? 139.585 138.291 190.200 1.00 104.63 ? 441 PRO   A CA  1 
ATOM   3070 C  C   . PRO   A 1 392 ? 139.882 136.916 189.629 1.00 111.01 ? 441 PRO   A C   1 
ATOM   3071 O  O   . PRO   A 1 392 ? 140.554 136.796 188.601 1.00 119.63 ? 441 PRO   A O   1 
ATOM   3072 C  CB  . PRO   A 1 392 ? 140.528 138.642 191.354 1.00 102.90 ? 441 PRO   A CB  1 
ATOM   3073 C  CG  . PRO   A 1 392 ? 139.804 138.208 192.576 1.00 108.62 ? 441 PRO   A CG  1 
ATOM   3074 C  CD  . PRO   A 1 392 ? 138.325 138.239 192.289 1.00 109.77 ? 441 PRO   A CD  1 
ATOM   3075 N  N   . PHE   A 1 393 ? 139.383 135.873 190.289 1.00 97.79  ? 442 PHE   A N   1 
ATOM   3076 C  CA  . PHE   A 1 393 ? 139.538 134.500 189.832 1.00 99.77  ? 442 PHE   A CA  1 
ATOM   3077 C  C   . PHE   A 1 393 ? 138.304 133.987 189.106 1.00 101.41 ? 442 PHE   A C   1 
ATOM   3078 O  O   . PHE   A 1 393 ? 138.235 132.797 188.788 1.00 108.85 ? 442 PHE   A O   1 
ATOM   3079 C  CB  . PHE   A 1 393 ? 139.854 133.581 191.013 1.00 93.55  ? 442 PHE   A CB  1 
ATOM   3080 C  CG  . PHE   A 1 393 ? 141.144 133.901 191.708 1.00 95.74  ? 442 PHE   A CG  1 
ATOM   3081 C  CD1 . PHE   A 1 393 ? 142.348 133.443 191.209 1.00 96.96  ? 442 PHE   A CD1 1 
ATOM   3082 C  CD2 . PHE   A 1 393 ? 141.150 134.653 192.867 1.00 105.30 ? 442 PHE   A CD2 1 
ATOM   3083 C  CE1 . PHE   A 1 393 ? 143.533 133.734 191.853 1.00 102.44 ? 442 PHE   A CE1 1 
ATOM   3084 C  CE2 . PHE   A 1 393 ? 142.333 134.948 193.513 1.00 104.81 ? 442 PHE   A CE2 1 
ATOM   3085 C  CZ  . PHE   A 1 393 ? 143.525 134.488 193.004 1.00 104.31 ? 442 PHE   A CZ  1 
ATOM   3086 N  N   . GLY   A 1 394 ? 137.332 134.853 188.840 1.00 107.12 ? 443 GLY   A N   1 
ATOM   3087 C  CA  . GLY   A 1 394 ? 136.049 134.422 188.332 1.00 110.55 ? 443 GLY   A CA  1 
ATOM   3088 C  C   . GLY   A 1 394 ? 135.146 133.938 189.451 1.00 119.38 ? 443 GLY   A C   1 
ATOM   3089 O  O   . GLY   A 1 394 ? 135.564 133.719 190.589 1.00 124.79 ? 443 GLY   A O   1 
ATOM   3090 N  N   . ALA   A 1 395 ? 133.871 133.769 189.116 1.00 116.86 ? 444 ALA   A N   1 
ATOM   3091 C  CA  . ALA   A 1 395 ? 132.894 133.308 190.089 1.00 118.17 ? 444 ALA   A CA  1 
ATOM   3092 C  C   . ALA   A 1 395 ? 131.785 132.563 189.365 1.00 123.43 ? 444 ALA   A C   1 
ATOM   3093 O  O   . ALA   A 1 395 ? 131.640 132.651 188.144 1.00 123.75 ? 444 ALA   A O   1 
ATOM   3094 C  CB  . ALA   A 1 395 ? 132.326 134.467 190.912 1.00 114.81 ? 444 ALA   A CB  1 
ATOM   3095 N  N   . GLY   A 1 396 ? 131.000 131.826 190.138 1.00 126.07 ? 445 GLY   A N   1 
ATOM   3096 C  CA  . GLY   A 1 396 ? 129.943 131.020 189.552 1.00 121.84 ? 445 GLY   A CA  1 
ATOM   3097 C  C   . GLY   A 1 396 ? 130.510 129.742 188.986 1.00 123.48 ? 445 GLY   A C   1 
ATOM   3098 O  O   . GLY   A 1 396 ? 131.336 129.082 189.620 1.00 123.89 ? 445 GLY   A O   1 
ATOM   3099 N  N   . ARG   A 1 397 ? 130.066 129.383 187.782 1.00 118.13 ? 446 ARG   A N   1 
ATOM   3100 C  CA  . ARG   A 1 397 ? 130.551 128.160 187.156 1.00 118.15 ? 446 ARG   A CA  1 
ATOM   3101 C  C   . ARG   A 1 397 ? 131.972 128.320 186.630 1.00 120.39 ? 446 ARG   A C   1 
ATOM   3102 O  O   . ARG   A 1 397 ? 132.772 127.382 186.704 1.00 123.97 ? 446 ARG   A O   1 
ATOM   3103 C  CB  . ARG   A 1 397 ? 129.615 127.742 186.025 1.00 118.54 ? 446 ARG   A CB  1 
ATOM   3104 C  CG  . ARG   A 1 397 ? 128.213 127.376 186.474 1.00 115.40 ? 446 ARG   A CG  1 
ATOM   3105 C  CD  . ARG   A 1 397 ? 127.655 126.266 185.605 1.00 119.71 ? 446 ARG   A CD  1 
ATOM   3106 N  NE  . ARG   A 1 397 ? 128.724 125.503 184.970 1.00 124.15 ? 446 ARG   A NE  1 
ATOM   3107 C  CZ  . ARG   A 1 397 ? 128.707 125.089 183.711 1.00 123.94 ? 446 ARG   A CZ  1 
ATOM   3108 N  NH1 . ARG   A 1 397 ? 127.691 125.357 182.910 1.00 119.53 ? 446 ARG   A NH1 1 
ATOM   3109 N  NH2 . ARG   A 1 397 ? 129.739 124.392 183.244 1.00 120.58 ? 446 ARG   A NH2 1 
ATOM   3110 N  N   . HIS   A 1 398 ? 132.304 129.495 186.100 1.00 110.24 ? 447 HIS   A N   1 
ATOM   3111 C  CA  . HIS   A 1 398 ? 133.596 129.722 185.455 1.00 110.60 ? 447 HIS   A CA  1 
ATOM   3112 C  C   . HIS   A 1 398 ? 134.546 130.347 186.469 1.00 111.48 ? 447 HIS   A C   1 
ATOM   3113 O  O   . HIS   A 1 398 ? 134.544 131.563 186.675 1.00 109.32 ? 447 HIS   A O   1 
ATOM   3114 C  CB  . HIS   A 1 398 ? 133.433 130.605 184.224 1.00 108.27 ? 447 HIS   A CB  1 
ATOM   3115 C  CG  . HIS   A 1 398 ? 132.418 130.098 183.247 1.00 108.90 ? 447 HIS   A CG  1 
ATOM   3116 N  ND1 . HIS   A 1 398 ? 131.972 130.849 182.182 1.00 113.69 ? 447 HIS   A ND1 1 
ATOM   3117 C  CD2 . HIS   A 1 398 ? 131.766 128.914 183.171 1.00 109.57 ? 447 HIS   A CD2 1 
ATOM   3118 C  CE1 . HIS   A 1 398 ? 131.086 130.152 181.494 1.00 114.26 ? 447 HIS   A CE1 1 
ATOM   3119 N  NE2 . HIS   A 1 398 ? 130.943 128.974 182.073 1.00 114.55 ? 447 HIS   A NE2 1 
ATOM   3120 N  N   . ARG   A 1 399 ? 135.366 129.512 187.101 1.00 113.01 ? 448 ARG   A N   1 
ATOM   3121 C  CA  . ARG   A 1 399 ? 136.353 129.958 188.071 1.00 109.55 ? 448 ARG   A CA  1 
ATOM   3122 C  C   . ARG   A 1 399 ? 137.700 129.328 187.756 1.00 110.39 ? 448 ARG   A C   1 
ATOM   3123 O  O   . ARG   A 1 399 ? 137.792 128.336 187.029 1.00 111.22 ? 448 ARG   A O   1 
ATOM   3124 C  CB  . ARG   A 1 399 ? 135.952 129.600 189.508 1.00 109.24 ? 448 ARG   A CB  1 
ATOM   3125 C  CG  . ARG   A 1 399 ? 134.511 129.899 189.864 1.00 115.22 ? 448 ARG   A CG  1 
ATOM   3126 C  CD  . ARG   A 1 399 ? 134.257 129.664 191.343 1.00 113.63 ? 448 ARG   A CD  1 
ATOM   3127 N  NE  . ARG   A 1 399 ? 134.591 130.835 192.144 1.00 117.59 ? 448 ARG   A NE  1 
ATOM   3128 C  CZ  . ARG   A 1 399 ? 135.769 131.042 192.716 1.00 117.21 ? 448 ARG   A CZ  1 
ATOM   3129 N  NH1 . ARG   A 1 399 ? 136.753 130.166 192.608 1.00 114.94 ? 448 ARG   A NH1 1 
ATOM   3130 N  NH2 . ARG   A 1 399 ? 135.964 132.157 193.414 1.00 108.89 ? 448 ARG   A NH2 1 
ATOM   3131 N  N   . CYS   A 1 400 ? 138.749 129.920 188.314 1.00 107.66 ? 449 CYS   A N   1 
ATOM   3132 C  CA  . CYS   A 1 400 ? 140.077 129.338 188.197 1.00 106.16 ? 449 CYS   A CA  1 
ATOM   3133 C  C   . CYS   A 1 400 ? 140.157 128.050 189.003 1.00 111.46 ? 449 CYS   A C   1 
ATOM   3134 O  O   . CYS   A 1 400 ? 139.684 127.979 190.140 1.00 120.74 ? 449 CYS   A O   1 
ATOM   3135 C  CB  . CYS   A 1 400 ? 141.135 130.325 188.682 1.00 108.20 ? 449 CYS   A CB  1 
ATOM   3136 S  SG  . CYS   A 1 400 ? 142.813 129.926 188.158 1.00 122.53 ? 449 CYS   A SG  1 
ATOM   3137 N  N   . ILE   A 1 401 ? 140.763 127.019 188.404 1.00 107.14 ? 450 ILE   A N   1 
ATOM   3138 C  CA  . ILE   A 1 401 ? 140.952 125.750 189.104 1.00 103.03 ? 450 ILE   A CA  1 
ATOM   3139 C  C   . ILE   A 1 401 ? 142.181 125.756 189.992 1.00 101.35 ? 450 ILE   A C   1 
ATOM   3140 O  O   . ILE   A 1 401 ? 142.475 124.739 190.633 1.00 108.29 ? 450 ILE   A O   1 
ATOM   3141 C  CB  . ILE   A 1 401 ? 141.064 124.570 188.119 1.00 99.53  ? 450 ILE   A CB  1 
ATOM   3142 C  CG1 . ILE   A 1 401 ? 142.323 124.703 187.265 1.00 101.85 ? 450 ILE   A CG1 1 
ATOM   3143 C  CG2 . ILE   A 1 401 ? 139.839 124.506 187.238 1.00 97.48  ? 450 ILE   A CG2 1 
ATOM   3144 C  CD1 . ILE   A 1 401 ? 142.614 123.480 186.434 1.00 103.88 ? 450 ILE   A CD1 1 
ATOM   3145 N  N   . GLY   A 1 402 ? 142.907 126.865 190.050 1.00 84.71  ? 451 GLY   A N   1 
ATOM   3146 C  CA  . GLY   A 1 402 ? 144.100 126.935 190.862 1.00 85.58  ? 451 GLY   A CA  1 
ATOM   3147 C  C   . GLY   A 1 402 ? 144.180 128.204 191.679 1.00 86.63  ? 451 GLY   A C   1 
ATOM   3148 O  O   . GLY   A 1 402 ? 145.276 128.707 191.941 1.00 89.02  ? 451 GLY   A O   1 
ATOM   3149 N  N   . GLU   A 1 403 ? 143.029 128.742 192.084 1.00 109.18 ? 452 GLU   A N   1 
ATOM   3150 C  CA  . GLU   A 1 403 ? 143.049 129.911 192.956 1.00 114.64 ? 452 GLU   A CA  1 
ATOM   3151 C  C   . GLU   A 1 403 ? 143.655 129.567 194.310 1.00 114.81 ? 452 GLU   A C   1 
ATOM   3152 O  O   . GLU   A 1 403 ? 144.354 130.391 194.909 1.00 121.45 ? 452 GLU   A O   1 
ATOM   3153 C  CB  . GLU   A 1 403 ? 141.641 130.491 193.109 1.00 117.18 ? 452 GLU   A CB  1 
ATOM   3154 C  CG  . GLU   A 1 403 ? 140.794 129.862 194.202 1.00 115.40 ? 452 GLU   A CG  1 
ATOM   3155 C  CD  . GLU   A 1 403 ? 139.556 130.674 194.519 1.00 119.18 ? 452 GLU   A CD  1 
ATOM   3156 O  OE1 . GLU   A 1 403 ? 139.696 131.778 195.085 1.00 123.94 ? 452 GLU   A OE1 1 
ATOM   3157 O  OE2 . GLU   A 1 403 ? 138.442 130.207 194.205 1.00 120.58 ? 452 GLU   A OE2 1 
ATOM   3158 N  N   . ASN   A 1 404 ? 143.416 128.348 194.802 1.00 107.02 ? 453 ASN   A N   1 
ATOM   3159 C  CA  . ASN   A 1 404 ? 144.052 127.919 196.043 1.00 103.18 ? 453 ASN   A CA  1 
ATOM   3160 C  C   . ASN   A 1 404 ? 145.562 127.828 195.877 1.00 97.91  ? 453 ASN   A C   1 
ATOM   3161 O  O   . ASN   A 1 404 ? 146.319 128.240 196.764 1.00 109.63 ? 453 ASN   A O   1 
ATOM   3162 C  CB  . ASN   A 1 404 ? 143.480 126.577 196.494 1.00 104.82 ? 453 ASN   A CB  1 
ATOM   3163 C  CG  . ASN   A 1 404 ? 141.994 126.461 196.233 1.00 110.25 ? 453 ASN   A CG  1 
ATOM   3164 O  OD1 . ASN   A 1 404 ? 141.196 127.215 196.787 1.00 115.05 ? 453 ASN   A OD1 1 
ATOM   3165 N  ND2 . ASN   A 1 404 ? 141.615 125.512 195.386 1.00 102.80 ? 453 ASN   A ND2 1 
ATOM   3166 N  N   . PHE   A 1 405 ? 146.020 127.300 194.741 1.00 91.26  ? 454 PHE   A N   1 
ATOM   3167 C  CA  . PHE   A 1 405 ? 147.456 127.232 194.504 1.00 96.25  ? 454 PHE   A CA  1 
ATOM   3168 C  C   . PHE   A 1 405 ? 148.061 128.622 194.381 1.00 97.55  ? 454 PHE   A C   1 
ATOM   3169 O  O   . PHE   A 1 405 ? 149.184 128.853 194.834 1.00 108.81 ? 454 PHE   A O   1 
ATOM   3170 C  CB  . PHE   A 1 405 ? 147.761 126.411 193.256 1.00 102.16 ? 454 PHE   A CB  1 
ATOM   3171 C  CG  . PHE   A 1 405 ? 149.226 126.190 193.032 1.00 94.73  ? 454 PHE   A CG  1 
ATOM   3172 C  CD1 . PHE   A 1 405 ? 150.009 125.623 194.021 1.00 99.58  ? 454 PHE   A CD1 1 
ATOM   3173 C  CD2 . PHE   A 1 405 ? 149.825 126.559 191.842 1.00 95.21  ? 454 PHE   A CD2 1 
ATOM   3174 C  CE1 . PHE   A 1 405 ? 151.357 125.420 193.826 1.00 104.79 ? 454 PHE   A CE1 1 
ATOM   3175 C  CE2 . PHE   A 1 405 ? 151.174 126.360 191.641 1.00 101.87 ? 454 PHE   A CE2 1 
ATOM   3176 C  CZ  . PHE   A 1 405 ? 151.941 125.789 192.634 1.00 107.50 ? 454 PHE   A CZ  1 
ATOM   3177 N  N   . ALA   A 1 406 ? 147.342 129.561 193.765 1.00 89.42  ? 455 ALA   A N   1 
ATOM   3178 C  CA  . ALA   A 1 406 ? 147.840 130.931 193.697 1.00 88.21  ? 455 ALA   A CA  1 
ATOM   3179 C  C   . ALA   A 1 406 ? 147.921 131.555 195.084 1.00 87.19  ? 455 ALA   A C   1 
ATOM   3180 O  O   . ALA   A 1 406 ? 148.908 132.218 195.420 1.00 88.39  ? 455 ALA   A O   1 
ATOM   3181 C  CB  . ALA   A 1 406 ? 146.950 131.770 192.783 1.00 94.95  ? 455 ALA   A CB  1 
ATOM   3182 N  N   . TYR   A 1 407 ? 146.890 131.350 195.906 1.00 105.96 ? 456 TYR   A N   1 
ATOM   3183 C  CA  . TYR   A 1 407 ? 146.882 131.911 197.251 1.00 101.66 ? 456 TYR   A CA  1 
ATOM   3184 C  C   . TYR   A 1 407 ? 147.883 131.230 198.170 1.00 100.12 ? 456 TYR   A C   1 
ATOM   3185 O  O   . TYR   A 1 407 ? 148.200 131.780 199.227 1.00 109.40 ? 456 TYR   A O   1 
ATOM   3186 C  CB  . TYR   A 1 407 ? 145.484 131.811 197.860 1.00 105.13 ? 456 TYR   A CB  1 
ATOM   3187 C  CG  . TYR   A 1 407 ? 144.592 132.987 197.551 1.00 99.94  ? 456 TYR   A CG  1 
ATOM   3188 C  CD1 . TYR   A 1 407 ? 145.100 134.130 196.953 1.00 97.77  ? 456 TYR   A CD1 1 
ATOM   3189 C  CD2 . TYR   A 1 407 ? 143.241 132.955 197.860 1.00 105.13 ? 456 TYR   A CD2 1 
ATOM   3190 C  CE1 . TYR   A 1 407 ? 144.287 135.206 196.669 1.00 111.49 ? 456 TYR   A CE1 1 
ATOM   3191 C  CE2 . TYR   A 1 407 ? 142.421 134.026 197.581 1.00 101.25 ? 456 TYR   A CE2 1 
ATOM   3192 C  CZ  . TYR   A 1 407 ? 142.948 135.149 196.985 1.00 109.49 ? 456 TYR   A CZ  1 
ATOM   3193 O  OH  . TYR   A 1 407 ? 142.131 136.218 196.706 1.00 112.96 ? 456 TYR   A OH  1 
ATOM   3194 N  N   . VAL   A 1 408 ? 148.360 130.039 197.815 1.00 78.26  ? 457 VAL   A N   1 
ATOM   3195 C  CA  . VAL   A 1 408 ? 149.407 129.393 198.597 1.00 74.42  ? 457 VAL   A CA  1 
ATOM   3196 C  C   . VAL   A 1 408 ? 150.795 129.648 198.019 1.00 90.40  ? 457 VAL   A C   1 
ATOM   3197 O  O   . VAL   A 1 408 ? 151.793 129.472 198.734 1.00 101.35 ? 457 VAL   A O   1 
ATOM   3198 C  CB  . VAL   A 1 408 ? 149.152 127.877 198.720 1.00 88.30  ? 457 VAL   A CB  1 
ATOM   3199 C  CG1 . VAL   A 1 408 ? 149.708 127.138 197.516 1.00 95.47  ? 457 VAL   A CG1 1 
ATOM   3200 C  CG2 . VAL   A 1 408 ? 149.746 127.346 200.002 1.00 90.27  ? 457 VAL   A CG2 1 
ATOM   3201 N  N   . GLN   A 1 409 ? 150.889 130.057 196.754 1.00 101.25 ? 458 GLN   A N   1 
ATOM   3202 C  CA  . GLN   A 1 409 ? 152.171 130.381 196.145 1.00 90.89  ? 458 GLN   A CA  1 
ATOM   3203 C  C   . GLN   A 1 409 ? 152.572 131.816 196.442 1.00 93.61  ? 458 GLN   A C   1 
ATOM   3204 O  O   . GLN   A 1 409 ? 153.682 132.070 196.919 1.00 102.96 ? 458 GLN   A O   1 
ATOM   3205 C  CB  . GLN   A 1 409 ? 152.099 130.159 194.634 1.00 90.96  ? 458 GLN   A CB  1 
ATOM   3206 C  CG  . GLN   A 1 409 ? 153.402 129.747 193.991 1.00 88.21  ? 458 GLN   A CG  1 
ATOM   3207 C  CD  . GLN   A 1 409 ? 153.390 129.959 192.493 1.00 98.06  ? 458 GLN   A CD  1 
ATOM   3208 O  OE1 . GLN   A 1 409 ? 152.397 130.414 191.928 1.00 92.53  ? 458 GLN   A OE1 1 
ATOM   3209 N  NE2 . GLN   A 1 409 ? 154.497 129.631 191.841 1.00 107.57 ? 458 GLN   A NE2 1 
ATOM   3210 N  N   . ILE   A 1 410 ? 151.685 132.768 196.150 1.00 97.31  ? 459 ILE   A N   1 
ATOM   3211 C  CA  . ILE   A 1 410 ? 152.011 134.172 196.371 1.00 88.27  ? 459 ILE   A CA  1 
ATOM   3212 C  C   . ILE   A 1 410 ? 152.138 134.466 197.858 1.00 87.41  ? 459 ILE   A C   1 
ATOM   3213 O  O   . ILE   A 1 410 ? 153.037 135.198 198.282 1.00 96.53  ? 459 ILE   A O   1 
ATOM   3214 C  CB  . ILE   A 1 410 ? 150.965 135.079 195.703 1.00 79.69  ? 459 ILE   A CB  1 
ATOM   3215 C  CG1 . ILE   A 1 410 ? 150.628 134.573 194.305 1.00 91.41  ? 459 ILE   A CG1 1 
ATOM   3216 C  CG2 . ILE   A 1 410 ? 151.493 136.479 195.601 1.00 86.54  ? 459 ILE   A CG2 1 
ATOM   3217 C  CD1 . ILE   A 1 410 ? 149.461 135.289 193.669 1.00 85.27  ? 459 ILE   A CD1 1 
ATOM   3218 N  N   . LYS   A 1 411 ? 151.297 133.861 198.677 1.00 88.91  ? 460 LYS   A N   1 
ATOM   3219 C  CA  . LYS   A 1 411 ? 151.357 134.100 200.139 1.00 92.27  ? 460 LYS   A CA  1 
ATOM   3220 C  C   . LYS   A 1 411 ? 152.524 133.338 200.780 1.00 99.05  ? 460 LYS   A C   1 
ATOM   3221 O  O   . LYS   A 1 411 ? 152.719 133.520 201.979 1.00 110.09 ? 460 LYS   A O   1 
ATOM   3222 C  CB  . LYS   A 1 411 ? 150.003 133.802 200.786 1.00 88.65  ? 460 LYS   A CB  1 
ATOM   3223 C  CG  . LYS   A 1 411 ? 149.790 134.301 202.206 1.00 97.72  ? 460 LYS   A CG  1 
ATOM   3224 C  CD  . LYS   A 1 411 ? 148.344 134.613 202.509 1.00 105.67 ? 460 LYS   A CD  1 
ATOM   3225 C  CE  . LYS   A 1 411 ? 147.398 133.500 202.120 1.00 103.49 ? 460 LYS   A CE  1 
ATOM   3226 N  NZ  . LYS   A 1 411 ? 147.419 132.397 203.108 1.00 110.33 ? 460 LYS   A NZ  1 
ATOM   3227 N  N   . THR   A 1 412 ? 153.280 132.521 200.036 1.00 87.72  ? 461 THR   A N   1 
ATOM   3228 C  CA  . THR   A 1 412 ? 154.485 131.851 200.608 1.00 83.42  ? 461 THR   A CA  1 
ATOM   3229 C  C   . THR   A 1 412 ? 155.725 132.518 200.027 1.00 98.61  ? 461 THR   A C   1 
ATOM   3230 O  O   . THR   A 1 412 ? 156.755 132.535 200.703 1.00 111.56 ? 461 THR   A O   1 
ATOM   3231 C  CB  . THR   A 1 412 ? 154.464 130.347 200.368 1.00 85.63  ? 461 THR   A CB  1 
ATOM   3232 O  OG1 . THR   A 1 412 ? 153.276 129.856 200.983 1.00 94.96  ? 461 THR   A OG1 1 
ATOM   3233 C  CG2 . THR   A 1 412 ? 155.652 129.638 200.973 1.00 93.50  ? 461 THR   A CG2 1 
ATOM   3234 N  N   . ILE   A 1 413 ? 155.627 133.052 198.821 1.00 97.16  ? 462 ILE   A N   1 
ATOM   3235 C  CA  . ILE   A 1 413 ? 156.698 133.831 198.209 1.00 88.49  ? 462 ILE   A CA  1 
ATOM   3236 C  C   . ILE   A 1 413 ? 156.840 135.164 198.921 1.00 98.21  ? 462 ILE   A C   1 
ATOM   3237 O  O   . ILE   A 1 413 ? 157.938 135.561 199.326 1.00 102.89 ? 462 ILE   A O   1 
ATOM   3238 C  CB  . ILE   A 1 413 ? 156.422 134.032 196.708 1.00 85.94  ? 462 ILE   A CB  1 
ATOM   3239 C  CG1 . ILE   A 1 413 ? 156.837 132.806 195.906 1.00 96.43  ? 462 ILE   A CG1 1 
ATOM   3240 C  CG2 . ILE   A 1 413 ? 157.143 135.253 196.185 1.00 91.33  ? 462 ILE   A CG2 1 
ATOM   3241 C  CD1 . ILE   A 1 413 ? 156.314 132.821 194.497 1.00 103.70 ? 462 ILE   A CD1 1 
ATOM   3242 N  N   . TRP   A 1 414 ? 155.721 135.861 199.119 1.00 107.06 ? 463 TRP   A N   1 
ATOM   3243 C  CA  . TRP   A 1 414 ? 155.788 137.185 199.712 1.00 101.41 ? 463 TRP   A CA  1 
ATOM   3244 C  C   . TRP   A 1 414 ? 156.012 137.128 201.211 1.00 102.95 ? 463 TRP   A C   1 
ATOM   3245 O  O   . TRP   A 1 414 ? 156.628 138.039 201.766 1.00 124.47 ? 463 TRP   A O   1 
ATOM   3246 C  CB  . TRP   A 1 414 ? 154.528 137.977 199.378 1.00 94.60  ? 463 TRP   A CB  1 
ATOM   3247 C  CG  . TRP   A 1 414 ? 154.744 138.756 198.146 1.00 97.50  ? 463 TRP   A CG  1 
ATOM   3248 C  CD1 . TRP   A 1 414 ? 154.190 138.529 196.925 1.00 104.20 ? 463 TRP   A CD1 1 
ATOM   3249 C  CD2 . TRP   A 1 414 ? 155.662 139.836 197.978 1.00 106.42 ? 463 TRP   A CD2 1 
ATOM   3250 N  NE1 . TRP   A 1 414 ? 154.669 139.437 196.014 1.00 102.38 ? 463 TRP   A NE1 1 
ATOM   3251 C  CE2 . TRP   A 1 414 ? 155.579 140.249 196.638 1.00 110.07 ? 463 TRP   A CE2 1 
ATOM   3252 C  CE3 . TRP   A 1 414 ? 156.531 140.510 198.839 1.00 114.29 ? 463 TRP   A CE3 1 
ATOM   3253 C  CZ2 . TRP   A 1 414 ? 156.334 141.300 196.137 1.00 110.18 ? 463 TRP   A CZ2 1 
ATOM   3254 C  CZ3 . TRP   A 1 414 ? 157.275 141.554 198.342 1.00 115.19 ? 463 TRP   A CZ3 1 
ATOM   3255 C  CH2 . TRP   A 1 414 ? 157.175 141.939 197.004 1.00 109.85 ? 463 TRP   A CH2 1 
ATOM   3256 N  N   . SER   A 1 415 ? 155.605 136.038 201.842 1.00 87.12  ? 464 SER   A N   1 
ATOM   3257 C  CA  . SER   A 1 415 ? 155.901 135.910 203.285 1.00 92.94  ? 464 SER   A CA  1 
ATOM   3258 C  C   . SER   A 1 415 ? 157.400 135.799 203.477 1.00 103.80 ? 464 SER   A C   1 
ATOM   3259 O  O   . SER   A 1 415 ? 157.922 136.445 204.384 1.00 117.97 ? 464 SER   A O   1 
ATOM   3260 C  CB  . SER   A 1 415 ? 155.268 134.724 203.874 1.00 105.72 ? 464 SER   A CB  1 
ATOM   3261 O  OG  . SER   A 1 415 ? 153.876 134.912 203.963 1.00 116.02 ? 464 SER   A OG  1 
ATOM   3262 N  N   . THR   A 1 416 ? 158.047 134.951 202.693 1.00 102.99 ? 465 THR   A N   1 
ATOM   3263 C  CA  . THR   A 1 416 ? 159.498 134.848 202.784 1.00 109.28 ? 465 THR   A CA  1 
ATOM   3264 C  C   . THR   A 1 416 ? 160.185 136.132 202.335 1.00 115.53 ? 465 THR   A C   1 
ATOM   3265 O  O   . THR   A 1 416 ? 161.183 136.546 202.938 1.00 127.37 ? 465 THR   A O   1 
ATOM   3266 C  CB  . THR   A 1 416 ? 159.995 133.669 201.957 1.00 109.34 ? 465 THR   A CB  1 
ATOM   3267 O  OG1 . THR   A 1 416 ? 159.157 132.533 202.200 1.00 116.71 ? 465 THR   A OG1 1 
ATOM   3268 C  CG2 . THR   A 1 416 ? 161.422 133.326 202.341 1.00 113.52 ? 465 THR   A CG2 1 
ATOM   3269 N  N   . MET   A 1 417 ? 159.663 136.778 201.292 1.00 108.14 ? 466 MET   A N   1 
ATOM   3270 C  CA  . MET   A 1 417 ? 160.295 137.981 200.767 1.00 103.92 ? 466 MET   A CA  1 
ATOM   3271 C  C   . MET   A 1 417 ? 160.235 139.125 201.772 1.00 108.46 ? 466 MET   A C   1 
ATOM   3272 O  O   . MET   A 1 417 ? 161.211 139.867 201.933 1.00 114.94 ? 466 MET   A O   1 
ATOM   3273 C  CB  . MET   A 1 417 ? 159.621 138.372 199.455 1.00 99.82  ? 466 MET   A CB  1 
ATOM   3274 C  CG  . MET   A 1 417 ? 160.350 139.431 198.678 1.00 109.52 ? 466 MET   A CG  1 
ATOM   3275 S  SD  . MET   A 1 417 ? 159.767 139.556 196.981 1.00 117.84 ? 466 MET   A SD  1 
ATOM   3276 C  CE  . MET   A 1 417 ? 159.610 137.829 196.561 1.00 103.49 ? 466 MET   A CE  1 
ATOM   3277 N  N   . LEU   A 1 418 ? 159.106 139.278 202.465 1.00 96.09  ? 467 LEU   A N   1 
ATOM   3278 C  CA  . LEU   A 1 418 ? 159.004 140.277 203.519 1.00 90.69  ? 467 LEU   A CA  1 
ATOM   3279 C  C   . LEU   A 1 418 ? 159.815 139.881 204.741 1.00 100.89 ? 467 LEU   A C   1 
ATOM   3280 O  O   . LEU   A 1 418 ? 160.303 140.755 205.464 1.00 115.72 ? 467 LEU   A O   1 
ATOM   3281 C  CB  . LEU   A 1 418 ? 157.540 140.492 203.905 1.00 101.24 ? 467 LEU   A CB  1 
ATOM   3282 C  CG  . LEU   A 1 418 ? 156.646 141.092 202.819 1.00 102.60 ? 467 LEU   A CG  1 
ATOM   3283 C  CD1 . LEU   A 1 418 ? 155.281 141.445 203.381 1.00 102.06 ? 467 LEU   A CD1 1 
ATOM   3284 C  CD2 . LEU   A 1 418 ? 157.304 142.311 202.204 1.00 104.77 ? 467 LEU   A CD2 1 
ATOM   3285 N  N   . ARG   A 1 419 ? 159.968 138.578 204.991 1.00 106.44 ? 468 ARG   A N   1 
ATOM   3286 C  CA  . ARG   A 1 419 ? 160.867 138.135 206.048 1.00 112.01 ? 468 ARG   A CA  1 
ATOM   3287 C  C   . ARG   A 1 419 ? 162.313 138.485 205.731 1.00 114.53 ? 468 ARG   A C   1 
ATOM   3288 O  O   . ARG   A 1 419 ? 163.122 138.671 206.646 1.00 114.03 ? 468 ARG   A O   1 
ATOM   3289 C  CB  . ARG   A 1 419 ? 160.729 136.629 206.253 1.00 114.93 ? 468 ARG   A CB  1 
ATOM   3290 C  CG  . ARG   A 1 419 ? 159.879 136.224 207.436 1.00 119.95 ? 468 ARG   A CG  1 
ATOM   3291 C  CD  . ARG   A 1 419 ? 159.967 134.727 207.657 1.00 114.79 ? 468 ARG   A CD  1 
ATOM   3292 N  NE  . ARG   A 1 419 ? 158.815 134.215 208.386 1.00 118.03 ? 468 ARG   A NE  1 
ATOM   3293 C  CZ  . ARG   A 1 419 ? 158.644 132.942 208.713 1.00 120.09 ? 468 ARG   A CZ  1 
ATOM   3294 N  NH1 . ARG   A 1 419 ? 159.533 132.019 208.387 1.00 119.86 ? 468 ARG   A NH1 1 
ATOM   3295 N  NH2 . ARG   A 1 419 ? 157.550 132.585 209.377 1.00 119.33 ? 468 ARG   A NH2 1 
ATOM   3296 N  N   . LEU   A 1 420 ? 162.658 138.575 204.447 1.00 114.61 ? 469 LEU   A N   1 
ATOM   3297 C  CA  . LEU   A 1 420 ? 164.041 138.815 204.049 1.00 113.57 ? 469 LEU   A CA  1 
ATOM   3298 C  C   . LEU   A 1 420 ? 164.372 140.304 203.967 1.00 115.69 ? 469 LEU   A C   1 
ATOM   3299 O  O   . LEU   A 1 420 ? 165.258 140.787 204.677 1.00 123.69 ? 469 LEU   A O   1 
ATOM   3300 C  CB  . LEU   A 1 420 ? 164.324 138.131 202.707 1.00 116.91 ? 469 LEU   A CB  1 
ATOM   3301 C  CG  . LEU   A 1 420 ? 164.487 136.611 202.733 1.00 117.94 ? 469 LEU   A CG  1 
ATOM   3302 C  CD1 . LEU   A 1 420 ? 165.186 136.127 201.475 1.00 116.37 ? 469 LEU   A CD1 1 
ATOM   3303 C  CD2 . LEU   A 1 420 ? 165.246 136.168 203.972 1.00 113.27 ? 469 LEU   A CD2 1 
ATOM   3304 N  N   . TYR   A 1 421 ? 163.670 141.039 203.113 1.00 120.61 ? 470 TYR   A N   1 
ATOM   3305 C  CA  . TYR   A 1 421 ? 164.022 142.415 202.794 1.00 124.97 ? 470 TYR   A CA  1 
ATOM   3306 C  C   . TYR   A 1 421 ? 163.010 143.389 203.392 1.00 125.51 ? 470 TYR   A C   1 
ATOM   3307 O  O   . TYR   A 1 421 ? 162.055 143.003 204.070 1.00 130.51 ? 470 TYR   A O   1 
ATOM   3308 C  CB  . TYR   A 1 421 ? 164.124 142.599 201.279 1.00 123.27 ? 470 TYR   A CB  1 
ATOM   3309 C  CG  . TYR   A 1 421 ? 165.259 141.830 200.648 1.00 130.15 ? 470 TYR   A CG  1 
ATOM   3310 C  CD1 . TYR   A 1 421 ? 166.477 141.697 201.298 1.00 130.56 ? 470 TYR   A CD1 1 
ATOM   3311 C  CD2 . TYR   A 1 421 ? 165.113 141.236 199.403 1.00 128.52 ? 470 TYR   A CD2 1 
ATOM   3312 C  CE1 . TYR   A 1 421 ? 167.518 140.994 200.726 1.00 124.77 ? 470 TYR   A CE1 1 
ATOM   3313 C  CE2 . TYR   A 1 421 ? 166.149 140.531 198.823 1.00 128.44 ? 470 TYR   A CE2 1 
ATOM   3314 C  CZ  . TYR   A 1 421 ? 167.348 140.414 199.490 1.00 125.72 ? 470 TYR   A CZ  1 
ATOM   3315 O  OH  . TYR   A 1 421 ? 168.384 139.713 198.918 1.00 129.10 ? 470 TYR   A OH  1 
ATOM   3316 N  N   . GLU   A 1 422 ? 163.243 144.675 203.131 1.00 131.17 ? 471 GLU   A N   1 
ATOM   3317 C  CA  . GLU   A 1 422 ? 162.353 145.766 203.529 1.00 129.57 ? 471 GLU   A CA  1 
ATOM   3318 C  C   . GLU   A 1 422 ? 162.176 146.646 202.296 1.00 130.65 ? 471 GLU   A C   1 
ATOM   3319 O  O   . GLU   A 1 422 ? 162.942 147.587 202.078 1.00 133.67 ? 471 GLU   A O   1 
ATOM   3320 C  CB  . GLU   A 1 422 ? 162.917 146.548 204.709 1.00 134.27 ? 471 GLU   A CB  1 
ATOM   3321 C  CG  . GLU   A 1 422 ? 161.997 147.647 205.216 1.00 137.01 ? 471 GLU   A CG  1 
ATOM   3322 C  CD  . GLU   A 1 422 ? 162.753 148.876 205.679 1.00 139.31 ? 471 GLU   A CD  1 
ATOM   3323 O  OE1 . GLU   A 1 422 ? 163.818 149.175 205.100 1.00 137.65 ? 471 GLU   A OE1 1 
ATOM   3324 O  OE2 . GLU   A 1 422 ? 162.281 149.545 206.622 1.00 139.03 ? 471 GLU   A OE2 1 
ATOM   3325 N  N   . PHE   A 1 423 ? 161.162 146.337 201.495 1.00 130.07 ? 472 PHE   A N   1 
ATOM   3326 C  CA  . PHE   A 1 423 ? 160.982 146.986 200.205 1.00 134.42 ? 472 PHE   A CA  1 
ATOM   3327 C  C   . PHE   A 1 423 ? 160.582 148.446 200.361 1.00 137.79 ? 472 PHE   A C   1 
ATOM   3328 O  O   . PHE   A 1 423 ? 159.811 148.806 201.255 1.00 140.90 ? 472 PHE   A O   1 
ATOM   3329 C  CB  . PHE   A 1 423 ? 159.939 146.235 199.380 1.00 132.83 ? 472 PHE   A CB  1 
ATOM   3330 C  CG  . PHE   A 1 423 ? 160.436 144.933 198.836 1.00 129.43 ? 472 PHE   A CG  1 
ATOM   3331 C  CD1 . PHE   A 1 423 ? 160.703 143.871 199.677 1.00 131.24 ? 472 PHE   A CD1 1 
ATOM   3332 C  CD2 . PHE   A 1 423 ? 160.647 144.776 197.480 1.00 133.97 ? 472 PHE   A CD2 1 
ATOM   3333 C  CE1 . PHE   A 1 423 ? 161.171 142.683 199.175 1.00 133.60 ? 472 PHE   A CE1 1 
ATOM   3334 C  CE2 . PHE   A 1 423 ? 161.110 143.588 196.971 1.00 138.96 ? 472 PHE   A CE2 1 
ATOM   3335 C  CZ  . PHE   A 1 423 ? 161.374 142.541 197.818 1.00 136.79 ? 472 PHE   A CZ  1 
ATOM   3336 N  N   . ASP   A 1 424 ? 161.118 149.285 199.478 1.00 149.70 ? 473 ASP   A N   1 
ATOM   3337 C  CA  . ASP   A 1 424 ? 160.848 150.716 199.490 1.00 152.99 ? 473 ASP   A CA  1 
ATOM   3338 C  C   . ASP   A 1 424 ? 160.914 151.237 198.064 1.00 154.64 ? 473 ASP   A C   1 
ATOM   3339 O  O   . ASP   A 1 424 ? 161.870 150.943 197.341 1.00 159.83 ? 473 ASP   A O   1 
ATOM   3340 C  CB  . ASP   A 1 424 ? 161.853 151.457 200.378 1.00 158.18 ? 473 ASP   A CB  1 
ATOM   3341 C  CG  . ASP   A 1 424 ? 161.452 152.894 200.637 1.00 160.56 ? 473 ASP   A CG  1 
ATOM   3342 O  OD1 . ASP   A 1 424 ? 160.699 153.137 201.603 1.00 161.40 ? 473 ASP   A OD1 1 
ATOM   3343 O  OD2 . ASP   A 1 424 ? 161.893 153.781 199.876 1.00 156.80 ? 473 ASP   A OD2 1 
ATOM   3344 N  N   . LEU   A 1 425 ? 159.908 152.012 197.669 1.00 148.63 ? 474 LEU   A N   1 
ATOM   3345 C  CA  . LEU   A 1 425 ? 159.857 152.541 196.315 1.00 149.84 ? 474 LEU   A CA  1 
ATOM   3346 C  C   . LEU   A 1 425 ? 161.008 153.514 196.076 1.00 150.07 ? 474 LEU   A C   1 
ATOM   3347 O  O   . LEU   A 1 425 ? 161.569 154.099 197.006 1.00 149.32 ? 474 LEU   A O   1 
ATOM   3348 C  CB  . LEU   A 1 425 ? 158.519 153.236 196.062 1.00 149.26 ? 474 LEU   A CB  1 
ATOM   3349 C  CG  . LEU   A 1 425 ? 157.632 152.633 194.971 1.00 149.10 ? 474 LEU   A CG  1 
ATOM   3350 C  CD1 . LEU   A 1 425 ? 156.459 153.547 194.668 1.00 145.64 ? 474 LEU   A CD1 1 
ATOM   3351 C  CD2 . LEU   A 1 425 ? 158.439 152.360 193.713 1.00 150.39 ? 474 LEU   A CD2 1 
ATOM   3352 N  N   . ILE   A 1 426 ? 161.362 153.680 194.804 1.00 163.91 ? 475 ILE   A N   1 
ATOM   3353 C  CA  . ILE   A 1 426 ? 162.466 154.540 194.394 1.00 166.15 ? 475 ILE   A CA  1 
ATOM   3354 C  C   . ILE   A 1 426 ? 161.895 155.803 193.761 1.00 168.00 ? 475 ILE   A C   1 
ATOM   3355 O  O   . ILE   A 1 426 ? 161.041 155.731 192.868 1.00 167.95 ? 475 ILE   A O   1 
ATOM   3356 C  CB  . ILE   A 1 426 ? 163.429 153.811 193.437 1.00 164.06 ? 475 ILE   A CB  1 
ATOM   3357 C  CG1 . ILE   A 1 426 ? 164.617 154.707 193.083 1.00 165.85 ? 475 ILE   A CG1 1 
ATOM   3358 C  CG2 . ILE   A 1 426 ? 162.708 153.308 192.190 1.00 161.36 ? 475 ILE   A CG2 1 
ATOM   3359 C  CD1 . ILE   A 1 426 ? 165.626 154.047 192.171 1.00 166.15 ? 475 ILE   A CD1 1 
ATOM   3360 N  N   . ASP   A 1 427 ? 162.341 156.960 194.256 1.00 177.50 ? 476 ASP   A N   1 
ATOM   3361 C  CA  . ASP   A 1 427 ? 161.944 158.273 193.741 1.00 177.21 ? 476 ASP   A CA  1 
ATOM   3362 C  C   . ASP   A 1 427 ? 160.432 158.483 193.782 1.00 176.08 ? 476 ASP   A C   1 
ATOM   3363 O  O   . ASP   A 1 427 ? 159.905 159.364 193.096 1.00 174.92 ? 476 ASP   A O   1 
ATOM   3364 C  CB  . ASP   A 1 427 ? 162.471 158.492 192.319 1.00 177.52 ? 476 ASP   A CB  1 
ATOM   3365 C  CG  . ASP   A 1 427 ? 163.822 159.174 192.299 1.00 177.42 ? 476 ASP   A CG  1 
ATOM   3366 O  OD1 . ASP   A 1 427 ? 164.232 159.712 193.349 1.00 176.08 ? 476 ASP   A OD1 1 
ATOM   3367 O  OD2 . ASP   A 1 427 ? 164.476 159.169 191.235 1.00 176.57 ? 476 ASP   A OD2 1 
ATOM   3368 N  N   . GLY   A 1 428 ? 159.721 157.689 194.580 1.00 172.31 ? 477 GLY   A N   1 
ATOM   3369 C  CA  . GLY   A 1 428 ? 158.276 157.819 194.667 1.00 172.39 ? 477 GLY   A CA  1 
ATOM   3370 C  C   . GLY   A 1 428 ? 157.552 157.560 193.366 1.00 172.50 ? 477 GLY   A C   1 
ATOM   3371 O  O   . GLY   A 1 428 ? 156.438 158.058 193.174 1.00 172.39 ? 477 GLY   A O   1 
ATOM   3372 N  N   . TYR   A 1 429 ? 158.155 156.792 192.463 1.00 175.40 ? 478 TYR   A N   1 
ATOM   3373 C  CA  . TYR   A 1 429 ? 157.569 156.494 191.159 1.00 176.61 ? 478 TYR   A CA  1 
ATOM   3374 C  C   . TYR   A 1 429 ? 156.867 155.143 191.240 1.00 176.37 ? 478 TYR   A C   1 
ATOM   3375 O  O   . TYR   A 1 429 ? 157.503 154.093 191.123 1.00 176.60 ? 478 TYR   A O   1 
ATOM   3376 C  CB  . TYR   A 1 429 ? 158.636 156.498 190.070 1.00 175.77 ? 478 TYR   A CB  1 
ATOM   3377 C  CG  . TYR   A 1 429 ? 158.180 155.874 188.769 1.00 177.10 ? 478 TYR   A CG  1 
ATOM   3378 C  CD1 . TYR   A 1 429 ? 157.024 156.309 188.134 1.00 177.18 ? 478 TYR   A CD1 1 
ATOM   3379 C  CD2 . TYR   A 1 429 ? 158.901 154.844 188.181 1.00 173.95 ? 478 TYR   A CD2 1 
ATOM   3380 C  CE1 . TYR   A 1 429 ? 156.603 155.738 186.949 1.00 177.02 ? 478 TYR   A CE1 1 
ATOM   3381 C  CE2 . TYR   A 1 429 ? 158.487 154.268 186.996 1.00 173.34 ? 478 TYR   A CE2 1 
ATOM   3382 C  CZ  . TYR   A 1 429 ? 157.338 154.719 186.384 1.00 175.41 ? 478 TYR   A CZ  1 
ATOM   3383 O  OH  . TYR   A 1 429 ? 156.921 154.149 185.204 1.00 175.24 ? 478 TYR   A OH  1 
ATOM   3384 N  N   . PHE   A 1 430 ? 155.559 155.171 191.439 1.00 157.23 ? 479 PHE   A N   1 
ATOM   3385 C  CA  . PHE   A 1 430 ? 154.776 153.946 191.381 1.00 155.86 ? 479 PHE   A CA  1 
ATOM   3386 C  C   . PHE   A 1 430 ? 154.641 153.516 189.928 1.00 157.74 ? 479 PHE   A C   1 
ATOM   3387 O  O   . PHE   A 1 430 ? 154.168 154.307 189.101 1.00 158.84 ? 479 PHE   A O   1 
ATOM   3388 C  CB  . PHE   A 1 430 ? 153.403 154.151 192.012 1.00 153.41 ? 479 PHE   A CB  1 
ATOM   3389 C  CG  . PHE   A 1 430 ? 152.602 152.889 192.137 1.00 154.92 ? 479 PHE   A CG  1 
ATOM   3390 C  CD1 . PHE   A 1 430 ? 152.805 152.028 193.201 1.00 157.23 ? 479 PHE   A CD1 1 
ATOM   3391 C  CD2 . PHE   A 1 430 ? 151.648 152.561 191.190 1.00 156.48 ? 479 PHE   A CD2 1 
ATOM   3392 C  CE1 . PHE   A 1 430 ? 152.072 150.865 193.318 1.00 158.97 ? 479 PHE   A CE1 1 
ATOM   3393 C  CE2 . PHE   A 1 430 ? 150.911 151.399 191.302 1.00 156.27 ? 479 PHE   A CE2 1 
ATOM   3394 C  CZ  . PHE   A 1 430 ? 151.124 150.550 192.367 1.00 158.99 ? 479 PHE   A CZ  1 
ATOM   3395 N  N   . PRO   A 1 431 ? 155.051 152.301 189.566 1.00 158.18 ? 480 PRO   A N   1 
ATOM   3396 C  CA  . PRO   A 1 431 ? 154.979 151.886 188.162 1.00 156.24 ? 480 PRO   A CA  1 
ATOM   3397 C  C   . PRO   A 1 431 ? 153.552 151.911 187.637 1.00 156.09 ? 480 PRO   A C   1 
ATOM   3398 O  O   . PRO   A 1 431 ? 152.603 151.558 188.339 1.00 157.61 ? 480 PRO   A O   1 
ATOM   3399 C  CB  . PRO   A 1 431 ? 155.542 150.462 188.199 1.00 156.28 ? 480 PRO   A CB  1 
ATOM   3400 C  CG  . PRO   A 1 431 ? 156.504 150.519 189.346 1.00 157.89 ? 480 PRO   A CG  1 
ATOM   3401 C  CD  . PRO   A 1 431 ? 155.716 151.273 190.383 1.00 157.35 ? 480 PRO   A CD  1 
ATOM   3402 N  N   . THR   A 1 432 ? 153.411 152.336 186.385 1.00 159.51 ? 481 THR   A N   1 
ATOM   3403 C  CA  . THR   A 1 432 ? 152.117 152.388 185.731 1.00 160.54 ? 481 THR   A CA  1 
ATOM   3404 C  C   . THR   A 1 432 ? 151.804 151.036 185.094 1.00 161.10 ? 481 THR   A C   1 
ATOM   3405 O  O   . THR   A 1 432 ? 152.525 150.052 185.272 1.00 161.92 ? 481 THR   A O   1 
ATOM   3406 C  CB  . THR   A 1 432 ? 152.087 153.511 184.696 1.00 161.20 ? 481 THR   A CB  1 
ATOM   3407 O  OG1 . THR   A 1 432 ? 153.132 153.307 183.737 1.00 163.57 ? 481 THR   A OG1 1 
ATOM   3408 C  CG2 . THR   A 1 432 ? 152.285 154.859 185.371 1.00 159.57 ? 481 THR   A CG2 1 
ATOM   3409 N  N   . VAL   A 1 433 ? 150.714 150.985 184.339 1.00 141.00 ? 482 VAL   A N   1 
ATOM   3410 C  CA  . VAL   A 1 433 ? 150.258 149.748 183.719 1.00 140.10 ? 482 VAL   A CA  1 
ATOM   3411 C  C   . VAL   A 1 433 ? 150.692 149.735 182.261 1.00 140.46 ? 482 VAL   A C   1 
ATOM   3412 O  O   . VAL   A 1 433 ? 150.411 150.676 181.509 1.00 143.37 ? 482 VAL   A O   1 
ATOM   3413 C  CB  . VAL   A 1 433 ? 148.733 149.604 183.840 1.00 139.81 ? 482 VAL   A CB  1 
ATOM   3414 C  CG1 . VAL   A 1 433 ? 148.212 148.641 182.797 1.00 142.29 ? 482 VAL   A CG1 1 
ATOM   3415 C  CG2 . VAL   A 1 433 ? 148.353 149.140 185.233 1.00 138.42 ? 482 VAL   A CG2 1 
ATOM   3416 N  N   . ASN   A 1 434 ? 151.379 148.669 181.859 1.00 154.50 ? 483 ASN   A N   1 
ATOM   3417 C  CA  . ASN   A 1 434 ? 151.799 148.484 180.472 1.00 156.72 ? 483 ASN   A CA  1 
ATOM   3418 C  C   . ASN   A 1 434 ? 150.685 147.752 179.737 1.00 158.89 ? 483 ASN   A C   1 
ATOM   3419 O  O   . ASN   A 1 434 ? 150.587 146.524 179.795 1.00 161.52 ? 483 ASN   A O   1 
ATOM   3420 C  CB  . ASN   A 1 434 ? 153.114 147.716 180.402 1.00 157.46 ? 483 ASN   A CB  1 
ATOM   3421 C  CG  . ASN   A 1 434 ? 153.745 147.768 179.027 1.00 157.33 ? 483 ASN   A CG  1 
ATOM   3422 O  OD1 . ASN   A 1 434 ? 153.554 148.727 178.280 1.00 160.10 ? 483 ASN   A OD1 1 
ATOM   3423 N  ND2 . ASN   A 1 434 ? 154.504 146.734 178.685 1.00 155.69 ? 483 ASN   A ND2 1 
ATOM   3424 N  N   . TYR   A 1 435 ? 149.840 148.509 179.037 1.00 156.16 ? 484 TYR   A N   1 
ATOM   3425 C  CA  . TYR   A 1 435 ? 148.700 147.922 178.344 1.00 154.80 ? 484 TYR   A CA  1 
ATOM   3426 C  C   . TYR   A 1 435 ? 149.098 147.116 177.115 1.00 155.43 ? 484 TYR   A C   1 
ATOM   3427 O  O   . TYR   A 1 435 ? 148.249 146.406 176.566 1.00 153.74 ? 484 TYR   A O   1 
ATOM   3428 C  CB  . TYR   A 1 435 ? 147.715 149.018 177.938 1.00 155.74 ? 484 TYR   A CB  1 
ATOM   3429 C  CG  . TYR   A 1 435 ? 147.066 149.722 179.106 1.00 155.21 ? 484 TYR   A CG  1 
ATOM   3430 C  CD1 . TYR   A 1 435 ? 146.123 149.077 179.893 1.00 154.01 ? 484 TYR   A CD1 1 
ATOM   3431 C  CD2 . TYR   A 1 435 ? 147.396 151.032 179.422 1.00 156.24 ? 484 TYR   A CD2 1 
ATOM   3432 C  CE1 . TYR   A 1 435 ? 145.521 149.719 180.956 1.00 157.12 ? 484 TYR   A CE1 1 
ATOM   3433 C  CE2 . TYR   A 1 435 ? 146.804 151.681 180.487 1.00 156.14 ? 484 TYR   A CE2 1 
ATOM   3434 C  CZ  . TYR   A 1 435 ? 145.868 151.019 181.251 1.00 156.79 ? 484 TYR   A CZ  1 
ATOM   3435 O  OH  . TYR   A 1 435 ? 145.276 151.662 182.313 1.00 153.22 ? 484 TYR   A OH  1 
ATOM   3436 N  N   . THR   A 1 436 ? 150.352 147.211 176.668 1.00 162.15 ? 485 THR   A N   1 
ATOM   3437 C  CA  . THR   A 1 436 ? 150.771 146.473 175.480 1.00 162.84 ? 485 THR   A CA  1 
ATOM   3438 C  C   . THR   A 1 436 ? 150.679 144.967 175.700 1.00 164.79 ? 485 THR   A C   1 
ATOM   3439 O  O   . THR   A 1 436 ? 150.204 144.233 174.826 1.00 163.06 ? 485 THR   A O   1 
ATOM   3440 C  CB  . THR   A 1 436 ? 152.192 146.873 175.087 1.00 165.24 ? 485 THR   A CB  1 
ATOM   3441 O  OG1 . THR   A 1 436 ? 153.114 146.412 176.083 1.00 165.88 ? 485 THR   A OG1 1 
ATOM   3442 C  CG2 . THR   A 1 436 ? 152.303 148.385 174.959 1.00 163.75 ? 485 THR   A CG2 1 
ATOM   3443 N  N   . THR   A 1 437 ? 151.126 144.490 176.858 1.00 167.46 ? 486 THR   A N   1 
ATOM   3444 C  CA  . THR   A 1 437 ? 151.035 143.072 177.168 1.00 165.40 ? 486 THR   A CA  1 
ATOM   3445 C  C   . THR   A 1 437 ? 149.589 142.674 177.446 1.00 162.79 ? 486 THR   A C   1 
ATOM   3446 O  O   . THR   A 1 437 ? 148.784 143.473 177.931 1.00 163.34 ? 486 THR   A O   1 
ATOM   3447 C  CB  . THR   A 1 437 ? 151.908 142.730 178.374 1.00 162.45 ? 486 THR   A CB  1 
ATOM   3448 O  OG1 . THR   A 1 437 ? 151.481 143.498 179.507 1.00 161.88 ? 486 THR   A OG1 1 
ATOM   3449 C  CG2 . THR   A 1 437 ? 153.364 143.045 178.080 1.00 162.11 ? 486 THR   A CG2 1 
ATOM   3450 N  N   . MET   A 1 438 ? 149.262 141.419 177.128 1.00 157.51 ? 487 MET   A N   1 
ATOM   3451 C  CA  . MET   A 1 438 ? 147.906 140.934 177.364 1.00 161.44 ? 487 MET   A CA  1 
ATOM   3452 C  C   . MET   A 1 438 ? 147.593 140.866 178.853 1.00 161.53 ? 487 MET   A C   1 
ATOM   3453 O  O   . MET   A 1 438 ? 146.472 141.178 179.271 1.00 158.64 ? 487 MET   A O   1 
ATOM   3454 C  CB  . MET   A 1 438 ? 147.703 139.575 176.696 1.00 160.08 ? 487 MET   A CB  1 
ATOM   3455 C  CG  . MET   A 1 438 ? 148.165 139.543 175.252 1.00 158.51 ? 487 MET   A CG  1 
ATOM   3456 S  SD  . MET   A 1 438 ? 147.876 141.129 174.440 1.00 163.76 ? 487 MET   A SD  1 
ATOM   3457 C  CE  . MET   A 1 438 ? 146.254 140.878 173.727 1.00 161.22 ? 487 MET   A CE  1 
ATOM   3458 N  N   . ILE   A 1 439 ? 148.561 140.460 179.667 1.00 148.22 ? 488 ILE   A N   1 
ATOM   3459 C  CA  . ILE   A 1 439 ? 148.474 140.604 181.114 1.00 146.40 ? 488 ILE   A CA  1 
ATOM   3460 C  C   . ILE   A 1 439 ? 149.209 141.883 181.483 1.00 149.12 ? 488 ILE   A C   1 
ATOM   3461 O  O   . ILE   A 1 439 ? 150.412 142.012 181.231 1.00 145.96 ? 488 ILE   A O   1 
ATOM   3462 C  CB  . ILE   A 1 439 ? 149.065 139.391 181.847 1.00 140.77 ? 488 ILE   A CB  1 
ATOM   3463 C  CG1 . ILE   A 1 439 ? 148.204 138.156 181.606 1.00 140.46 ? 488 ILE   A CG1 1 
ATOM   3464 C  CG2 . ILE   A 1 439 ? 149.134 139.664 183.330 1.00 141.95 ? 488 ILE   A CG2 1 
ATOM   3465 C  CD1 . ILE   A 1 439 ? 148.954 136.856 181.739 1.00 143.99 ? 488 ILE   A CD1 1 
ATOM   3466 N  N   . HIS   A 1 440 ? 148.487 142.829 182.074 1.00 153.80 ? 489 HIS   A N   1 
ATOM   3467 C  CA  . HIS   A 1 440 ? 149.029 144.159 182.327 1.00 147.10 ? 489 HIS   A CA  1 
ATOM   3468 C  C   . HIS   A 1 440 ? 150.126 144.081 183.380 1.00 147.09 ? 489 HIS   A C   1 
ATOM   3469 O  O   . HIS   A 1 440 ? 149.845 143.922 184.572 1.00 148.56 ? 489 HIS   A O   1 
ATOM   3470 C  CB  . HIS   A 1 440 ? 147.911 145.097 182.764 1.00 149.11 ? 489 HIS   A CB  1 
ATOM   3471 C  CG  . HIS   A 1 440 ? 146.888 145.348 181.701 1.00 150.85 ? 489 HIS   A CG  1 
ATOM   3472 N  ND1 . HIS   A 1 440 ? 147.053 144.928 180.399 1.00 151.68 ? 489 HIS   A ND1 1 
ATOM   3473 C  CD2 . HIS   A 1 440 ? 145.689 145.974 181.746 1.00 149.68 ? 489 HIS   A CD2 1 
ATOM   3474 C  CE1 . HIS   A 1 440 ? 146.000 145.285 179.687 1.00 151.38 ? 489 HIS   A CE1 1 
ATOM   3475 N  NE2 . HIS   A 1 440 ? 145.157 145.921 180.480 1.00 153.14 ? 489 HIS   A NE2 1 
ATOM   3476 N  N   . THR   A 1 441 ? 151.380 144.197 182.939 1.00 146.02 ? 490 THR   A N   1 
ATOM   3477 C  CA  . THR   A 1 441 ? 152.561 144.194 183.783 1.00 146.67 ? 490 THR   A CA  1 
ATOM   3478 C  C   . THR   A 1 441 ? 152.943 145.617 184.171 1.00 144.92 ? 490 THR   A C   1 
ATOM   3479 O  O   . THR   A 1 441 ? 152.681 146.562 183.421 1.00 150.79 ? 490 THR   A O   1 
ATOM   3480 C  CB  . THR   A 1 441 ? 153.742 143.537 183.064 1.00 146.29 ? 490 THR   A CB  1 
ATOM   3481 O  OG1 . THR   A 1 441 ? 154.169 144.374 181.982 1.00 150.87 ? 490 THR   A OG1 1 
ATOM   3482 C  CG2 . THR   A 1 441 ? 153.343 142.178 182.516 1.00 146.14 ? 490 THR   A CG2 1 
ATOM   3483 N  N   . PRO   A 1 442 ? 153.555 145.805 185.338 1.00 141.58 ? 491 PRO   A N   1 
ATOM   3484 C  CA  . PRO   A 1 442 ? 153.992 147.150 185.728 1.00 144.97 ? 491 PRO   A CA  1 
ATOM   3485 C  C   . PRO   A 1 442 ? 155.024 147.702 184.755 1.00 150.64 ? 491 PRO   A C   1 
ATOM   3486 O  O   . PRO   A 1 442 ? 155.849 146.965 184.210 1.00 150.76 ? 491 PRO   A O   1 
ATOM   3487 C  CB  . PRO   A 1 442 ? 154.585 146.942 187.126 1.00 146.18 ? 491 PRO   A CB  1 
ATOM   3488 C  CG  . PRO   A 1 442 ? 154.880 145.482 187.211 1.00 148.64 ? 491 PRO   A CG  1 
ATOM   3489 C  CD  . PRO   A 1 442 ? 153.830 144.811 186.388 1.00 148.16 ? 491 PRO   A CD  1 
ATOM   3490 N  N   . GLU   A 1 443 ? 154.968 149.013 184.540 1.00 169.08 ? 492 GLU   A N   1 
ATOM   3491 C  CA  . GLU   A 1 443 ? 155.882 149.689 183.630 1.00 168.52 ? 492 GLU   A CA  1 
ATOM   3492 C  C   . GLU   A 1 443 ? 157.133 150.127 184.380 1.00 168.55 ? 492 GLU   A C   1 
ATOM   3493 O  O   . GLU   A 1 443 ? 157.043 150.841 185.384 1.00 168.59 ? 492 GLU   A O   1 
ATOM   3494 C  CB  . GLU   A 1 443 ? 155.203 150.897 182.983 1.00 167.76 ? 492 GLU   A CB  1 
ATOM   3495 C  CG  . GLU   A 1 443 ? 155.984 151.499 181.828 1.00 169.36 ? 492 GLU   A CG  1 
ATOM   3496 C  CD  . GLU   A 1 443 ? 156.570 150.446 180.909 1.00 171.84 ? 492 GLU   A CD  1 
ATOM   3497 O  OE1 . GLU   A 1 443 ? 155.789 149.681 180.306 1.00 171.61 ? 492 GLU   A OE1 1 
ATOM   3498 O  OE2 . GLU   A 1 443 ? 157.811 150.383 180.791 1.00 171.95 ? 492 GLU   A OE2 1 
ATOM   3499 N  N   . ASN   A 1 444 ? 158.294 149.702 183.880 1.00 172.92 ? 493 ASN   A N   1 
ATOM   3500 C  CA  . ASN   A 1 444 ? 159.593 149.991 184.478 1.00 173.90 ? 493 ASN   A CA  1 
ATOM   3501 C  C   . ASN   A 1 444 ? 159.608 149.598 185.951 1.00 172.36 ? 493 ASN   A C   1 
ATOM   3502 O  O   . ASN   A 1 444 ? 159.684 150.471 186.825 1.00 170.53 ? 493 ASN   A O   1 
ATOM   3503 C  CB  . ASN   A 1 444 ? 159.943 151.472 184.317 1.00 172.15 ? 493 ASN   A CB  1 
ATOM   3504 C  CG  . ASN   A 1 444 ? 161.377 151.778 184.699 1.00 173.24 ? 493 ASN   A CG  1 
ATOM   3505 O  OD1 . ASN   A 1 444 ? 162.315 151.340 184.034 1.00 174.35 ? 493 ASN   A OD1 1 
ATOM   3506 N  ND2 . ASN   A 1 444 ? 161.554 152.532 185.777 1.00 173.58 ? 493 ASN   A ND2 1 
ATOM   3507 N  N   . PRO   A 1 445 ? 159.532 148.305 186.270 1.00 156.46 ? 494 PRO   A N   1 
ATOM   3508 C  CA  . PRO   A 1 445 ? 159.509 147.903 187.681 1.00 151.35 ? 494 PRO   A CA  1 
ATOM   3509 C  C   . PRO   A 1 445 ? 160.887 147.947 188.318 1.00 149.08 ? 494 PRO   A C   1 
ATOM   3510 O  O   . PRO   A 1 445 ? 161.719 147.075 188.062 1.00 151.07 ? 494 PRO   A O   1 
ATOM   3511 C  CB  . PRO   A 1 445 ? 158.964 146.467 187.632 1.00 153.56 ? 494 PRO   A CB  1 
ATOM   3512 C  CG  . PRO   A 1 445 ? 158.562 146.223 186.191 1.00 155.24 ? 494 PRO   A CG  1 
ATOM   3513 C  CD  . PRO   A 1 445 ? 159.400 147.145 185.379 1.00 154.14 ? 494 PRO   A CD  1 
ATOM   3514 N  N   . VAL   A 1 446 ? 161.139 148.950 189.153 1.00 150.47 ? 495 VAL   A N   1 
ATOM   3515 C  CA  . VAL   A 1 446 ? 162.405 149.077 189.866 1.00 152.69 ? 495 VAL   A CA  1 
ATOM   3516 C  C   . VAL   A 1 446 ? 162.099 149.487 191.299 1.00 154.79 ? 495 VAL   A C   1 
ATOM   3517 O  O   . VAL   A 1 446 ? 161.332 150.428 191.527 1.00 159.78 ? 495 VAL   A O   1 
ATOM   3518 C  CB  . VAL   A 1 446 ? 163.345 150.096 189.192 1.00 152.81 ? 495 VAL   A CB  1 
ATOM   3519 C  CG1 . VAL   A 1 446 ? 164.366 150.628 190.185 1.00 154.05 ? 495 VAL   A CG1 1 
ATOM   3520 C  CG2 . VAL   A 1 446 ? 164.040 149.463 187.998 1.00 150.53 ? 495 VAL   A CG2 1 
ATOM   3521 N  N   . ILE   A 1 447 ? 162.690 148.785 192.262 1.00 142.13 ? 496 ILE   A N   1 
ATOM   3522 C  CA  . ILE   A 1 447 ? 162.442 149.050 193.673 1.00 141.93 ? 496 ILE   A CA  1 
ATOM   3523 C  C   . ILE   A 1 447 ? 163.780 149.122 194.395 1.00 147.30 ? 496 ILE   A C   1 
ATOM   3524 O  O   . ILE   A 1 447 ? 164.708 148.370 194.081 1.00 152.55 ? 496 ILE   A O   1 
ATOM   3525 C  CB  . ILE   A 1 447 ? 161.531 147.974 194.298 1.00 137.34 ? 496 ILE   A CB  1 
ATOM   3526 C  CG1 . ILE   A 1 447 ? 161.157 148.352 195.722 1.00 144.55 ? 496 ILE   A CG1 1 
ATOM   3527 C  CG2 . ILE   A 1 447 ? 162.241 146.639 194.352 1.00 143.37 ? 496 ILE   A CG2 1 
ATOM   3528 C  CD1 . ILE   A 1 447 ? 159.830 147.798 196.137 1.00 146.91 ? 496 ILE   A CD1 1 
ATOM   3529 N  N   . ARG   A 1 448 ? 163.892 150.050 195.342 1.00 154.23 ? 497 ARG   A N   1 
ATOM   3530 C  CA  . ARG   A 1 448 ? 165.086 150.147 196.173 1.00 153.57 ? 497 ARG   A CA  1 
ATOM   3531 C  C   . ARG   A 1 448 ? 164.864 149.313 197.429 1.00 153.82 ? 497 ARG   A C   1 
ATOM   3532 O  O   . ARG   A 1 448 ? 164.199 149.757 198.371 1.00 156.71 ? 497 ARG   A O   1 
ATOM   3533 C  CB  . ARG   A 1 448 ? 165.386 151.603 196.516 1.00 150.47 ? 497 ARG   A CB  1 
ATOM   3534 C  CG  . ARG   A 1 448 ? 166.485 151.783 197.550 1.00 151.12 ? 497 ARG   A CG  1 
ATOM   3535 C  CD  . ARG   A 1 448 ? 166.368 153.119 198.264 1.00 155.66 ? 497 ARG   A CD  1 
ATOM   3536 N  NE  . ARG   A 1 448 ? 165.643 154.106 197.473 1.00 159.49 ? 497 ARG   A NE  1 
ATOM   3537 C  CZ  . ARG   A 1 448 ? 164.624 154.825 197.923 1.00 157.81 ? 497 ARG   A CZ  1 
ATOM   3538 N  NH1 . ARG   A 1 448 ? 164.176 154.690 199.161 1.00 154.76 ? 497 ARG   A NH1 1 
ATOM   3539 N  NH2 . ARG   A 1 448 ? 164.041 155.703 197.113 1.00 154.91 ? 497 ARG   A NH2 1 
ATOM   3540 N  N   . TYR   A 1 449 ? 165.414 148.106 197.446 1.00 144.33 ? 498 TYR   A N   1 
ATOM   3541 C  CA  . TYR   A 1 449 ? 165.219 147.177 198.547 1.00 143.72 ? 498 TYR   A CA  1 
ATOM   3542 C  C   . TYR   A 1 449 ? 166.383 147.251 199.525 1.00 143.39 ? 498 TYR   A C   1 
ATOM   3543 O  O   . TYR   A 1 449 ? 167.514 147.573 199.154 1.00 148.52 ? 498 TYR   A O   1 
ATOM   3544 C  CB  . TYR   A 1 449 ? 165.066 145.746 198.030 1.00 143.07 ? 498 TYR   A CB  1 
ATOM   3545 C  CG  . TYR   A 1 449 ? 166.188 145.297 197.124 1.00 142.12 ? 498 TYR   A CG  1 
ATOM   3546 C  CD1 . TYR   A 1 449 ? 167.376 144.805 197.647 1.00 145.81 ? 498 TYR   A CD1 1 
ATOM   3547 C  CD2 . TYR   A 1 449 ? 166.059 145.365 195.746 1.00 141.70 ? 498 TYR   A CD2 1 
ATOM   3548 C  CE1 . TYR   A 1 449 ? 168.403 144.396 196.825 1.00 145.01 ? 498 TYR   A CE1 1 
ATOM   3549 C  CE2 . TYR   A 1 449 ? 167.083 144.958 194.913 1.00 147.10 ? 498 TYR   A CE2 1 
ATOM   3550 C  CZ  . TYR   A 1 449 ? 168.252 144.474 195.459 1.00 147.74 ? 498 TYR   A CZ  1 
ATOM   3551 O  OH  . TYR   A 1 449 ? 169.275 144.065 194.635 1.00 147.12 ? 498 TYR   A OH  1 
ATOM   3552 N  N   . LYS   A 1 450 ? 166.091 146.953 200.787 1.00 139.75 ? 499 LYS   A N   1 
ATOM   3553 C  CA  . LYS   A 1 450 ? 167.099 146.876 201.830 1.00 141.56 ? 499 LYS   A CA  1 
ATOM   3554 C  C   . LYS   A 1 450 ? 166.822 145.656 202.694 1.00 141.55 ? 499 LYS   A C   1 
ATOM   3555 O  O   . LYS   A 1 450 ? 165.672 145.242 202.858 1.00 146.00 ? 499 LYS   A O   1 
ATOM   3556 C  CB  . LYS   A 1 450 ? 167.116 148.146 202.691 1.00 142.49 ? 499 LYS   A CB  1 
ATOM   3557 C  CG  . LYS   A 1 450 ? 168.375 148.319 203.524 1.00 142.33 ? 499 LYS   A CG  1 
ATOM   3558 C  CD  . LYS   A 1 450 ? 169.350 149.274 202.858 1.00 143.19 ? 499 LYS   A CD  1 
ATOM   3559 C  CE  . LYS   A 1 450 ? 170.520 149.593 203.772 1.00 145.24 ? 499 LYS   A CE  1 
ATOM   3560 N  NZ  . LYS   A 1 450 ? 171.145 148.358 204.321 1.00 144.77 ? 499 LYS   A NZ  1 
ATOM   3561 N  N   . ARG   A 1 451 ? 167.887 145.080 203.245 1.00 133.46 ? 500 ARG   A N   1 
ATOM   3562 C  CA  . ARG   A 1 451 ? 167.742 143.892 204.074 1.00 135.33 ? 500 ARG   A CA  1 
ATOM   3563 C  C   . ARG   A 1 451 ? 167.075 144.246 205.396 1.00 138.56 ? 500 ARG   A C   1 
ATOM   3564 O  O   . ARG   A 1 451 ? 167.445 145.227 206.048 1.00 139.33 ? 500 ARG   A O   1 
ATOM   3565 C  CB  . ARG   A 1 451 ? 169.104 143.248 204.322 1.00 136.97 ? 500 ARG   A CB  1 
ATOM   3566 C  CG  . ARG   A 1 451 ? 169.100 142.199 205.418 1.00 135.29 ? 500 ARG   A CG  1 
ATOM   3567 C  CD  . ARG   A 1 451 ? 168.773 140.826 204.862 1.00 134.60 ? 500 ARG   A CD  1 
ATOM   3568 N  NE  . ARG   A 1 451 ? 169.767 140.377 203.895 1.00 137.98 ? 500 ARG   A NE  1 
ATOM   3569 C  CZ  . ARG   A 1 451 ? 169.560 139.422 202.999 1.00 140.65 ? 500 ARG   A CZ  1 
ATOM   3570 N  NH1 . ARG   A 1 451 ? 168.403 138.787 202.921 1.00 139.14 ? 500 ARG   A NH1 1 
ATOM   3571 N  NH2 . ARG   A 1 451 ? 170.540 139.095 202.162 1.00 141.27 ? 500 ARG   A NH2 1 
ATOM   3572 N  N   . ARG   A 1 452 ? 166.084 143.448 205.785 1.00 136.30 ? 501 ARG   A N   1 
ATOM   3573 C  CA  . ARG   A 1 452 ? 165.404 143.661 207.054 1.00 137.89 ? 501 ARG   A CA  1 
ATOM   3574 C  C   . ARG   A 1 452 ? 166.357 143.423 208.218 1.00 139.43 ? 501 ARG   A C   1 
ATOM   3575 O  O   . ARG   A 1 452 ? 167.185 142.509 208.189 1.00 139.50 ? 501 ARG   A O   1 
ATOM   3576 C  CB  . ARG   A 1 452 ? 164.194 142.736 207.170 1.00 136.59 ? 501 ARG   A CB  1 
ATOM   3577 C  CG  . ARG   A 1 452 ? 163.229 143.120 208.276 1.00 133.98 ? 501 ARG   A CG  1 
ATOM   3578 C  CD  . ARG   A 1 452 ? 162.269 144.207 207.826 1.00 133.88 ? 501 ARG   A CD  1 
ATOM   3579 N  NE  . ARG   A 1 452 ? 161.516 143.817 206.641 1.00 132.26 ? 501 ARG   A NE  1 
ATOM   3580 C  CZ  . ARG   A 1 452 ? 160.423 144.434 206.214 1.00 132.48 ? 501 ARG   A CZ  1 
ATOM   3581 N  NH1 . ARG   A 1 452 ? 159.922 145.476 206.855 1.00 135.90 ? 501 ARG   A NH1 1 
ATOM   3582 N  NH2 . ARG   A 1 452 ? 159.818 143.994 205.115 1.00 132.25 ? 501 ARG   A NH2 1 
ATOM   3583 N  N   . SER   A 1 453 ? 166.236 144.256 209.247 1.00 147.89 ? 502 SER   A N   1 
ATOM   3584 C  CA  . SER   A 1 453 ? 167.088 144.151 210.425 1.00 146.12 ? 502 SER   A CA  1 
ATOM   3585 C  C   . SER   A 1 453 ? 166.816 142.860 211.190 1.00 146.07 ? 502 SER   A C   1 
ATOM   3586 O  O   . SER   A 1 453 ? 167.539 141.875 211.040 1.00 144.54 ? 502 SER   A O   1 
ATOM   3587 C  CB  . SER   A 1 453 ? 166.881 145.358 211.341 1.00 146.20 ? 502 SER   A CB  1 
ATOM   3588 O  OG  . SER   A 1 453 ? 167.004 146.571 210.620 1.00 144.64 ? 502 SER   A OG  1 
HETATM 3589 C  CHA . HEM   B 2 .   ? 141.583 130.145 184.646 1.00 99.04  ? 601 HEM   A CHA 1 
HETATM 3590 C  CHB . HEM   B 2 .   ? 142.883 134.139 187.061 1.00 103.73 ? 601 HEM   A CHB 1 
HETATM 3591 C  CHC . HEM   B 2 .   ? 146.765 131.808 188.748 1.00 102.73 ? 601 HEM   A CHC 1 
HETATM 3592 C  CHD . HEM   B 2 .   ? 145.336 127.749 186.546 1.00 97.94  ? 601 HEM   A CHD 1 
HETATM 3593 C  C1A . HEM   B 2 .   ? 141.553 131.398 185.212 1.00 94.25  ? 601 HEM   A C1A 1 
HETATM 3594 C  C2A . HEM   B 2 .   ? 140.451 132.337 185.157 1.00 97.66  ? 601 HEM   A C2A 1 
HETATM 3595 C  C3A . HEM   B 2 .   ? 140.810 133.434 185.821 1.00 93.17  ? 601 HEM   A C3A 1 
HETATM 3596 C  C4A . HEM   B 2 .   ? 142.152 133.238 186.322 1.00 95.98  ? 601 HEM   A C4A 1 
HETATM 3597 C  CMA . HEM   B 2 .   ? 139.947 134.696 186.022 1.00 98.48  ? 601 HEM   A CMA 1 
HETATM 3598 C  CAA . HEM   B 2 .   ? 139.092 132.117 184.459 1.00 107.49 ? 601 HEM   A CAA 1 
HETATM 3599 C  CBA . HEM   B 2 .   ? 139.271 131.980 182.953 1.00 104.33 ? 601 HEM   A CBA 1 
HETATM 3600 C  CGA . HEM   B 2 .   ? 137.945 131.611 182.346 1.00 109.88 ? 601 HEM   A CGA 1 
HETATM 3601 O  O1A . HEM   B 2 .   ? 137.837 131.609 181.093 1.00 116.89 ? 601 HEM   A O1A 1 
HETATM 3602 O  O2A . HEM   B 2 .   ? 136.994 131.322 183.115 1.00 111.08 ? 601 HEM   A O2A 1 
HETATM 3603 C  C1B . HEM   B 2 .   ? 144.011 133.834 187.786 1.00 100.14 ? 601 HEM   A C1B 1 
HETATM 3604 C  C2B . HEM   B 2 .   ? 144.620 134.663 188.805 1.00 93.70  ? 601 HEM   A C2B 1 
HETATM 3605 C  C3B . HEM   B 2 .   ? 145.699 134.013 189.273 1.00 90.56  ? 601 HEM   A C3B 1 
HETATM 3606 C  C4B . HEM   B 2 .   ? 145.794 132.761 188.559 1.00 92.60  ? 601 HEM   A C4B 1 
HETATM 3607 C  CMB . HEM   B 2 .   ? 144.059 136.040 189.219 1.00 95.86  ? 601 HEM   A CMB 1 
HETATM 3608 C  CAB . HEM   B 2 .   ? 146.725 134.413 190.362 1.00 104.73 ? 601 HEM   A CAB 1 
HETATM 3609 C  CBB . HEM   B 2 .   ? 146.700 135.553 191.056 1.00 114.46 ? 601 HEM   A CBB 1 
HETATM 3610 C  C1C . HEM   B 2 .   ? 146.639 130.483 188.415 1.00 103.11 ? 601 HEM   A C1C 1 
HETATM 3611 C  C2C . HEM   B 2 .   ? 147.329 129.383 189.042 1.00 98.06  ? 601 HEM   A C2C 1 
HETATM 3612 C  C3C . HEM   B 2 .   ? 146.943 128.255 188.454 1.00 95.06  ? 601 HEM   A C3C 1 
HETATM 3613 C  C4C . HEM   B 2 .   ? 145.988 128.599 187.411 1.00 96.29  ? 601 HEM   A C4C 1 
HETATM 3614 C  CMC . HEM   B 2 .   ? 148.334 129.497 190.206 1.00 106.17 ? 601 HEM   A CMC 1 
HETATM 3615 C  CAC . HEM   B 2 .   ? 147.472 126.862 188.856 1.00 104.75 ? 601 HEM   A CAC 1 
HETATM 3616 C  CBC . HEM   B 2 .   ? 146.946 125.734 188.378 1.00 103.94 ? 601 HEM   A CBC 1 
HETATM 3617 C  C1D . HEM   B 2 .   ? 144.261 128.075 185.751 1.00 97.28  ? 601 HEM   A C1D 1 
HETATM 3618 C  C2D . HEM   B 2 .   ? 143.725 127.267 184.681 1.00 95.71  ? 601 HEM   A C2D 1 
HETATM 3619 C  C3D . HEM   B 2 .   ? 142.683 127.899 184.142 1.00 100.65 ? 601 HEM   A C3D 1 
HETATM 3620 C  C4D . HEM   B 2 .   ? 142.526 129.161 184.856 1.00 98.95  ? 601 HEM   A C4D 1 
HETATM 3621 C  CMD . HEM   B 2 .   ? 144.264 125.892 184.241 1.00 98.74  ? 601 HEM   A CMD 1 
HETATM 3622 C  CAD . HEM   B 2 .   ? 141.878 127.308 182.953 1.00 99.63  ? 601 HEM   A CAD 1 
HETATM 3623 C  CBD . HEM   B 2 .   ? 140.435 127.783 182.797 1.00 109.22 ? 601 HEM   A CBD 1 
HETATM 3624 C  CGD . HEM   B 2 .   ? 139.575 127.300 183.934 1.00 117.53 ? 601 HEM   A CGD 1 
HETATM 3625 O  O1D . HEM   B 2 .   ? 138.351 127.586 183.917 1.00 122.21 ? 601 HEM   A O1D 1 
HETATM 3626 O  O2D . HEM   B 2 .   ? 140.105 126.626 184.852 1.00 115.26 ? 601 HEM   A O2D 1 
HETATM 3627 N  NA  . HEM   B 2 .   ? 142.575 131.982 185.932 1.00 95.53  ? 601 HEM   A NA  1 
HETATM 3628 N  NB  . HEM   B 2 .   ? 144.753 132.680 187.661 1.00 100.28 ? 601 HEM   A NB  1 
HETATM 3629 N  NC  . HEM   B 2 .   ? 145.828 129.971 187.424 1.00 101.43 ? 601 HEM   A NC  1 
HETATM 3630 N  ND  . HEM   B 2 .   ? 143.505 129.226 185.830 1.00 93.95  ? 601 HEM   A ND  1 
HETATM 3631 FE FE  . HEM   B 2 .   ? 144.191 130.973 186.674 1.00 114.59 ? 601 HEM   A FE  1 
HETATM 3632 C  C01 . A1D61 C 3 .   ? 147.318 132.366 181.170 1.00 142.94 ? 602 A1D61 A C01 1 
HETATM 3633 C  C04 . A1D61 C 3 .   ? 147.499 132.028 179.829 1.00 146.04 ? 602 A1D61 A C04 1 
HETATM 3634 C  C06 . A1D61 C 3 .   ? 144.950 131.953 180.957 1.00 140.95 ? 602 A1D61 A C06 1 
HETATM 3635 C  C02 . A1D61 C 3 .   ? 146.046 132.326 181.734 1.00 139.35 ? 602 A1D61 A C02 1 
HETATM 3636 C  C03 . A1D61 C 3 .   ? 146.404 131.652 179.048 1.00 143.12 ? 602 A1D61 A C03 1 
HETATM 3637 C  C10 . A1D61 C 3 .   ? 145.128 131.606 179.611 1.00 142.51 ? 602 A1D61 A C10 1 
HETATM 3638 C  C11 . A1D61 C 3 .   ? 143.903 131.200 178.737 1.00 144.41 ? 602 A1D61 A C11 1 
HETATM 3639 C  C13 . A1D61 C 3 .   ? 143.601 129.873 179.494 1.00 145.26 ? 602 A1D61 A C13 1 
HETATM 3640 C  C15 . A1D61 C 3 .   ? 144.425 127.607 180.413 1.00 142.91 ? 602 A1D61 A C15 1 
HETATM 3641 C  C16 . A1D61 C 3 .   ? 143.508 126.690 179.559 1.00 140.67 ? 602 A1D61 A C16 1 
HETATM 3642 C  C08 . A1D61 C 3 .   ? 149.553 133.172 179.726 1.00 140.62 ? 602 A1D61 A C08 1 
HETATM 3643 C  C09 . A1D61 C 3 .   ? 143.589 132.577 182.790 1.00 146.12 ? 602 A1D61 A C09 1 
HETATM 3644 C  C17 . A1D61 C 3 .   ? 143.476 125.231 180.063 1.00 140.77 ? 602 A1D61 A C17 1 
HETATM 3645 C  C18 . A1D61 C 3 .   ? 142.276 124.688 180.518 1.00 142.22 ? 602 A1D61 A C18 1 
HETATM 3646 C  C19 . A1D61 C 3 .   ? 142.236 123.373 180.973 1.00 140.89 ? 602 A1D61 A C19 1 
HETATM 3647 C  C20 . A1D61 C 3 .   ? 144.593 123.140 180.512 1.00 140.66 ? 602 A1D61 A C20 1 
HETATM 3648 C  C21 . A1D61 C 3 .   ? 144.635 124.457 180.059 1.00 140.05 ? 602 A1D61 A C21 1 
HETATM 3649 C  C22 . A1D61 C 3 .   ? 143.392 122.599 180.970 1.00 143.91 ? 602 A1D61 A C22 1 
HETATM 3650 C  C24 . A1D61 C 3 .   ? 143.299 131.796 177.692 1.00 143.33 ? 602 A1D61 A C24 1 
HETATM 3651 C  C25 . A1D61 C 3 .   ? 143.991 133.129 177.299 1.00 142.82 ? 602 A1D61 A C25 1 
HETATM 3652 C  C26 . A1D61 C 3 .   ? 144.075 134.191 178.200 1.00 144.20 ? 602 A1D61 A C26 1 
HETATM 3653 C  C27 . A1D61 C 3 .   ? 145.175 134.448 175.648 1.00 144.20 ? 602 A1D61 A C27 1 
HETATM 3654 C  C28 . A1D61 C 3 .   ? 144.544 133.261 176.022 1.00 141.54 ? 602 A1D61 A C28 1 
HETATM 3655 C  C29 . A1D61 C 3 .   ? 145.261 135.507 176.550 1.00 145.53 ? 602 A1D61 A C29 1 
HETATM 3656 C  C31 . A1D61 C 3 .   ? 144.709 135.376 177.825 1.00 145.11 ? 602 A1D61 A C31 1 
HETATM 3657 C  C33 . A1D61 C 3 .   ? 146.071 136.532 179.340 1.00 141.84 ? 602 A1D61 A C33 1 
HETATM 3658 N  N14 . A1D61 C 3 .   ? 144.688 128.879 179.696 1.00 143.76 ? 602 A1D61 A N14 1 
HETATM 3659 O  O05 . A1D61 C 3 .   ? 148.793 132.073 179.274 1.00 147.68 ? 602 A1D61 A O05 1 
HETATM 3660 O  O07 . A1D61 C 3 .   ? 143.664 131.921 181.540 1.00 144.46 ? 602 A1D61 A O07 1 
HETATM 3661 O  O12 . A1D61 C 3 .   ? 142.506 129.665 179.911 1.00 141.49 ? 602 A1D61 A O12 1 
HETATM 3662 O  O23 . A1D61 C 3 .   ? 143.340 121.272 181.428 1.00 150.88 ? 602 A1D61 A O23 1 
HETATM 3663 O  O30 . A1D61 C 3 .   ? 145.900 136.705 176.177 1.00 143.02 ? 602 A1D61 A O30 1 
HETATM 3664 O  O32 . A1D61 C 3 .   ? 144.799 136.445 178.735 1.00 145.56 ? 602 A1D61 A O32 1 
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