data_8YQH
# 
_entry.id   8YQH 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YQH         pdb_00008yqh 10.2210/pdb8yqh/pdb 
WWPDB D_1300045386 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YQH 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              michaelkchan88@cuhk.edu.hk 
_pdbx_contact_author.name_first         Michael 
_pdbx_contact_author.name_last          CHAN 
_pdbx_contact_author.name_mi            Kenneth 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9758-3243 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, J.'     1 0000-0001-8477-959X 
'Chan, M.K.' 2 0000-0002-9758-3243 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Am.Chem.Soc. 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            146 
_citation.language                  ? 
_citation.page_first                18817 
_citation.page_last                 18822 
_citation.title                     'Mechanoresponsive Protein Crystals for NADH Recycling in Multicycle Enzyme Reactions.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.4c04725 
_citation.pdbx_database_id_PubMed   38968608 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yekta, R.'    1 ?                   
primary 'Xiong, X.'    2 ?                   
primary 'Li, J.'       3 ?                   
primary 'Heater, B.S.' 4 ?                   
primary 'Lee, M.M.'    5 0000-0002-8627-1236 
primary 'Chan, M.K.'   6 0000-0002-9758-3243 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Cry3Aa protein' 73177.164 1 ? ? ? ? 
2 water   nat water            18.015    4 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Pesticidal protein' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNPNNRSEHDTIKTTENNEVPTNHVQYPLAETPNPTLEDLNYKEFLRMTADNNTEALDSSTTKDVIQKGISVVGDLLGVV
GFPFGGALVSFYTNFLNTIWPSEDPWKAFMEQVEALMDQKIADYAKNKALAELQGLQNNVEDYVSALSSWQKNPVSSRNP
HSQGRIRELFSQAESHFRNSMPSFAISGYEVLFLTTYAQAANTHLFLLKDAQIYGEEWGYEKEDIAEFYKRQLKLTQEYT
DHCVKWYNVGLDKLRGSSYESWVNFNRYRREMTLTVLDLIALFPLYDVRLYPKEVKTELTRDVLTDPIVGVNNLRGYGTT
FSNIENYIRKPHLFDYLHRIQFHTRFQPGYYGNDSFNYWSGNYVSTRPSIGSNDIITSPFYGNKSSEPVQNLEFNGEKVY
RAVANTNLAVWPSAVYSGVTKVEFSQYNDQTDEASTQTYDSKRNVGAVSWDSIDQLPPETTDEPLEKGYSHQLNYVMCFL
MQGSRGTIPVLTWTHKSVDFFNMIDSKKITQLPLVKAYKLQSGASVVAGPRFTGGDIIQCTENGSAATIYVTPDVSYSQK
YRARIHYASTSQITFTLSLDGAPFNQYYFDKTINKGDTLTYNSFNLASFSTPFELSGNNLQIGVTGLSAGDKVYIDKIEF
IPVN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNPNNRSEHDTIKTTENNEVPTNHVQYPLAETPNPTLEDLNYKEFLRMTADNNTEALDSSTTKDVIQKGISVVGDLLGVV
GFPFGGALVSFYTNFLNTIWPSEDPWKAFMEQVEALMDQKIADYAKNKALAELQGLQNNVEDYVSALSSWQKNPVSSRNP
HSQGRIRELFSQAESHFRNSMPSFAISGYEVLFLTTYAQAANTHLFLLKDAQIYGEEWGYEKEDIAEFYKRQLKLTQEYT
DHCVKWYNVGLDKLRGSSYESWVNFNRYRREMTLTVLDLIALFPLYDVRLYPKEVKTELTRDVLTDPIVGVNNLRGYGTT
FSNIENYIRKPHLFDYLHRIQFHTRFQPGYYGNDSFNYWSGNYVSTRPSIGSNDIITSPFYGNKSSEPVQNLEFNGEKVY
RAVANTNLAVWPSAVYSGVTKVEFSQYNDQTDEASTQTYDSKRNVGAVSWDSIDQLPPETTDEPLEKGYSHQLNYVMCFL
MQGSRGTIPVLTWTHKSVDFFNMIDSKKITQLPLVKAYKLQSGASVVAGPRFTGGDIIQCTENGSAATIYVTPDVSYSQK
YRARIHYASTSQITFTLSLDGAPFNQYYFDKTINKGDTLTYNSFNLASFSTPFELSGNNLQIGVTGLSAGDKVYIDKIEF
IPVN
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   PRO n 
1 4   ASN n 
1 5   ASN n 
1 6   ARG n 
1 7   SER n 
1 8   GLU n 
1 9   HIS n 
1 10  ASP n 
1 11  THR n 
1 12  ILE n 
1 13  LYS n 
1 14  THR n 
1 15  THR n 
1 16  GLU n 
1 17  ASN n 
1 18  ASN n 
1 19  GLU n 
1 20  VAL n 
1 21  PRO n 
1 22  THR n 
1 23  ASN n 
1 24  HIS n 
1 25  VAL n 
1 26  GLN n 
1 27  TYR n 
1 28  PRO n 
1 29  LEU n 
1 30  ALA n 
1 31  GLU n 
1 32  THR n 
1 33  PRO n 
1 34  ASN n 
1 35  PRO n 
1 36  THR n 
1 37  LEU n 
1 38  GLU n 
1 39  ASP n 
1 40  LEU n 
1 41  ASN n 
1 42  TYR n 
1 43  LYS n 
1 44  GLU n 
1 45  PHE n 
1 46  LEU n 
1 47  ARG n 
1 48  MET n 
1 49  THR n 
1 50  ALA n 
1 51  ASP n 
1 52  ASN n 
1 53  ASN n 
1 54  THR n 
1 55  GLU n 
1 56  ALA n 
1 57  LEU n 
1 58  ASP n 
1 59  SER n 
1 60  SER n 
1 61  THR n 
1 62  THR n 
1 63  LYS n 
1 64  ASP n 
1 65  VAL n 
1 66  ILE n 
1 67  GLN n 
1 68  LYS n 
1 69  GLY n 
1 70  ILE n 
1 71  SER n 
1 72  VAL n 
1 73  VAL n 
1 74  GLY n 
1 75  ASP n 
1 76  LEU n 
1 77  LEU n 
1 78  GLY n 
1 79  VAL n 
1 80  VAL n 
1 81  GLY n 
1 82  PHE n 
1 83  PRO n 
1 84  PHE n 
1 85  GLY n 
1 86  GLY n 
1 87  ALA n 
1 88  LEU n 
1 89  VAL n 
1 90  SER n 
1 91  PHE n 
1 92  TYR n 
1 93  THR n 
1 94  ASN n 
1 95  PHE n 
1 96  LEU n 
1 97  ASN n 
1 98  THR n 
1 99  ILE n 
1 100 TRP n 
1 101 PRO n 
1 102 SER n 
1 103 GLU n 
1 104 ASP n 
1 105 PRO n 
1 106 TRP n 
1 107 LYS n 
1 108 ALA n 
1 109 PHE n 
1 110 MET n 
1 111 GLU n 
1 112 GLN n 
1 113 VAL n 
1 114 GLU n 
1 115 ALA n 
1 116 LEU n 
1 117 MET n 
1 118 ASP n 
1 119 GLN n 
1 120 LYS n 
1 121 ILE n 
1 122 ALA n 
1 123 ASP n 
1 124 TYR n 
1 125 ALA n 
1 126 LYS n 
1 127 ASN n 
1 128 LYS n 
1 129 ALA n 
1 130 LEU n 
1 131 ALA n 
1 132 GLU n 
1 133 LEU n 
1 134 GLN n 
1 135 GLY n 
1 136 LEU n 
1 137 GLN n 
1 138 ASN n 
1 139 ASN n 
1 140 VAL n 
1 141 GLU n 
1 142 ASP n 
1 143 TYR n 
1 144 VAL n 
1 145 SER n 
1 146 ALA n 
1 147 LEU n 
1 148 SER n 
1 149 SER n 
1 150 TRP n 
1 151 GLN n 
1 152 LYS n 
1 153 ASN n 
1 154 PRO n 
1 155 VAL n 
1 156 SER n 
1 157 SER n 
1 158 ARG n 
1 159 ASN n 
1 160 PRO n 
1 161 HIS n 
1 162 SER n 
1 163 GLN n 
1 164 GLY n 
1 165 ARG n 
1 166 ILE n 
1 167 ARG n 
1 168 GLU n 
1 169 LEU n 
1 170 PHE n 
1 171 SER n 
1 172 GLN n 
1 173 ALA n 
1 174 GLU n 
1 175 SER n 
1 176 HIS n 
1 177 PHE n 
1 178 ARG n 
1 179 ASN n 
1 180 SER n 
1 181 MET n 
1 182 PRO n 
1 183 SER n 
1 184 PHE n 
1 185 ALA n 
1 186 ILE n 
1 187 SER n 
1 188 GLY n 
1 189 TYR n 
1 190 GLU n 
1 191 VAL n 
1 192 LEU n 
1 193 PHE n 
1 194 LEU n 
1 195 THR n 
1 196 THR n 
1 197 TYR n 
1 198 ALA n 
1 199 GLN n 
1 200 ALA n 
1 201 ALA n 
1 202 ASN n 
1 203 THR n 
1 204 HIS n 
1 205 LEU n 
1 206 PHE n 
1 207 LEU n 
1 208 LEU n 
1 209 LYS n 
1 210 ASP n 
1 211 ALA n 
1 212 GLN n 
1 213 ILE n 
1 214 TYR n 
1 215 GLY n 
1 216 GLU n 
1 217 GLU n 
1 218 TRP n 
1 219 GLY n 
1 220 TYR n 
1 221 GLU n 
1 222 LYS n 
1 223 GLU n 
1 224 ASP n 
1 225 ILE n 
1 226 ALA n 
1 227 GLU n 
1 228 PHE n 
1 229 TYR n 
1 230 LYS n 
1 231 ARG n 
1 232 GLN n 
1 233 LEU n 
1 234 LYS n 
1 235 LEU n 
1 236 THR n 
1 237 GLN n 
1 238 GLU n 
1 239 TYR n 
1 240 THR n 
1 241 ASP n 
1 242 HIS n 
1 243 CYS n 
1 244 VAL n 
1 245 LYS n 
1 246 TRP n 
1 247 TYR n 
1 248 ASN n 
1 249 VAL n 
1 250 GLY n 
1 251 LEU n 
1 252 ASP n 
1 253 LYS n 
1 254 LEU n 
1 255 ARG n 
1 256 GLY n 
1 257 SER n 
1 258 SER n 
1 259 TYR n 
1 260 GLU n 
1 261 SER n 
1 262 TRP n 
1 263 VAL n 
1 264 ASN n 
1 265 PHE n 
1 266 ASN n 
1 267 ARG n 
1 268 TYR n 
1 269 ARG n 
1 270 ARG n 
1 271 GLU n 
1 272 MET n 
1 273 THR n 
1 274 LEU n 
1 275 THR n 
1 276 VAL n 
1 277 LEU n 
1 278 ASP n 
1 279 LEU n 
1 280 ILE n 
1 281 ALA n 
1 282 LEU n 
1 283 PHE n 
1 284 PRO n 
1 285 LEU n 
1 286 TYR n 
1 287 ASP n 
1 288 VAL n 
1 289 ARG n 
1 290 LEU n 
1 291 TYR n 
1 292 PRO n 
1 293 LYS n 
1 294 GLU n 
1 295 VAL n 
1 296 LYS n 
1 297 THR n 
1 298 GLU n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 ASP n 
1 303 VAL n 
1 304 LEU n 
1 305 THR n 
1 306 ASP n 
1 307 PRO n 
1 308 ILE n 
1 309 VAL n 
1 310 GLY n 
1 311 VAL n 
1 312 ASN n 
1 313 ASN n 
1 314 LEU n 
1 315 ARG n 
1 316 GLY n 
1 317 TYR n 
1 318 GLY n 
1 319 THR n 
1 320 THR n 
1 321 PHE n 
1 322 SER n 
1 323 ASN n 
1 324 ILE n 
1 325 GLU n 
1 326 ASN n 
1 327 TYR n 
1 328 ILE n 
1 329 ARG n 
1 330 LYS n 
1 331 PRO n 
1 332 HIS n 
1 333 LEU n 
1 334 PHE n 
1 335 ASP n 
1 336 TYR n 
1 337 LEU n 
1 338 HIS n 
1 339 ARG n 
1 340 ILE n 
1 341 GLN n 
1 342 PHE n 
1 343 HIS n 
1 344 THR n 
1 345 ARG n 
1 346 PHE n 
1 347 GLN n 
1 348 PRO n 
1 349 GLY n 
1 350 TYR n 
1 351 TYR n 
1 352 GLY n 
1 353 ASN n 
1 354 ASP n 
1 355 SER n 
1 356 PHE n 
1 357 ASN n 
1 358 TYR n 
1 359 TRP n 
1 360 SER n 
1 361 GLY n 
1 362 ASN n 
1 363 TYR n 
1 364 VAL n 
1 365 SER n 
1 366 THR n 
1 367 ARG n 
1 368 PRO n 
1 369 SER n 
1 370 ILE n 
1 371 GLY n 
1 372 SER n 
1 373 ASN n 
1 374 ASP n 
1 375 ILE n 
1 376 ILE n 
1 377 THR n 
1 378 SER n 
1 379 PRO n 
1 380 PHE n 
1 381 TYR n 
1 382 GLY n 
1 383 ASN n 
1 384 LYS n 
1 385 SER n 
1 386 SER n 
1 387 GLU n 
1 388 PRO n 
1 389 VAL n 
1 390 GLN n 
1 391 ASN n 
1 392 LEU n 
1 393 GLU n 
1 394 PHE n 
1 395 ASN n 
1 396 GLY n 
1 397 GLU n 
1 398 LYS n 
1 399 VAL n 
1 400 TYR n 
1 401 ARG n 
1 402 ALA n 
1 403 VAL n 
1 404 ALA n 
1 405 ASN n 
1 406 THR n 
1 407 ASN n 
1 408 LEU n 
1 409 ALA n 
1 410 VAL n 
1 411 TRP n 
1 412 PRO n 
1 413 SER n 
1 414 ALA n 
1 415 VAL n 
1 416 TYR n 
1 417 SER n 
1 418 GLY n 
1 419 VAL n 
1 420 THR n 
1 421 LYS n 
1 422 VAL n 
1 423 GLU n 
1 424 PHE n 
1 425 SER n 
1 426 GLN n 
1 427 TYR n 
1 428 ASN n 
1 429 ASP n 
1 430 GLN n 
1 431 THR n 
1 432 ASP n 
1 433 GLU n 
1 434 ALA n 
1 435 SER n 
1 436 THR n 
1 437 GLN n 
1 438 THR n 
1 439 TYR n 
1 440 ASP n 
1 441 SER n 
1 442 LYS n 
1 443 ARG n 
1 444 ASN n 
1 445 VAL n 
1 446 GLY n 
1 447 ALA n 
1 448 VAL n 
1 449 SER n 
1 450 TRP n 
1 451 ASP n 
1 452 SER n 
1 453 ILE n 
1 454 ASP n 
1 455 GLN n 
1 456 LEU n 
1 457 PRO n 
1 458 PRO n 
1 459 GLU n 
1 460 THR n 
1 461 THR n 
1 462 ASP n 
1 463 GLU n 
1 464 PRO n 
1 465 LEU n 
1 466 GLU n 
1 467 LYS n 
1 468 GLY n 
1 469 TYR n 
1 470 SER n 
1 471 HIS n 
1 472 GLN n 
1 473 LEU n 
1 474 ASN n 
1 475 TYR n 
1 476 VAL n 
1 477 MET n 
1 478 CYS n 
1 479 PHE n 
1 480 LEU n 
1 481 MET n 
1 482 GLN n 
1 483 GLY n 
1 484 SER n 
1 485 ARG n 
1 486 GLY n 
1 487 THR n 
1 488 ILE n 
1 489 PRO n 
1 490 VAL n 
1 491 LEU n 
1 492 THR n 
1 493 TRP n 
1 494 THR n 
1 495 HIS n 
1 496 LYS n 
1 497 SER n 
1 498 VAL n 
1 499 ASP n 
1 500 PHE n 
1 501 PHE n 
1 502 ASN n 
1 503 MET n 
1 504 ILE n 
1 505 ASP n 
1 506 SER n 
1 507 LYS n 
1 508 LYS n 
1 509 ILE n 
1 510 THR n 
1 511 GLN n 
1 512 LEU n 
1 513 PRO n 
1 514 LEU n 
1 515 VAL n 
1 516 LYS n 
1 517 ALA n 
1 518 TYR n 
1 519 LYS n 
1 520 LEU n 
1 521 GLN n 
1 522 SER n 
1 523 GLY n 
1 524 ALA n 
1 525 SER n 
1 526 VAL n 
1 527 VAL n 
1 528 ALA n 
1 529 GLY n 
1 530 PRO n 
1 531 ARG n 
1 532 PHE n 
1 533 THR n 
1 534 GLY n 
1 535 GLY n 
1 536 ASP n 
1 537 ILE n 
1 538 ILE n 
1 539 GLN n 
1 540 CYS n 
1 541 THR n 
1 542 GLU n 
1 543 ASN n 
1 544 GLY n 
1 545 SER n 
1 546 ALA n 
1 547 ALA n 
1 548 THR n 
1 549 ILE n 
1 550 TYR n 
1 551 VAL n 
1 552 THR n 
1 553 PRO n 
1 554 ASP n 
1 555 VAL n 
1 556 SER n 
1 557 TYR n 
1 558 SER n 
1 559 GLN n 
1 560 LYS n 
1 561 TYR n 
1 562 ARG n 
1 563 ALA n 
1 564 ARG n 
1 565 ILE n 
1 566 HIS n 
1 567 TYR n 
1 568 ALA n 
1 569 SER n 
1 570 THR n 
1 571 SER n 
1 572 GLN n 
1 573 ILE n 
1 574 THR n 
1 575 PHE n 
1 576 THR n 
1 577 LEU n 
1 578 SER n 
1 579 LEU n 
1 580 ASP n 
1 581 GLY n 
1 582 ALA n 
1 583 PRO n 
1 584 PHE n 
1 585 ASN n 
1 586 GLN n 
1 587 TYR n 
1 588 TYR n 
1 589 PHE n 
1 590 ASP n 
1 591 LYS n 
1 592 THR n 
1 593 ILE n 
1 594 ASN n 
1 595 LYS n 
1 596 GLY n 
1 597 ASP n 
1 598 THR n 
1 599 LEU n 
1 600 THR n 
1 601 TYR n 
1 602 ASN n 
1 603 SER n 
1 604 PHE n 
1 605 ASN n 
1 606 LEU n 
1 607 ALA n 
1 608 SER n 
1 609 PHE n 
1 610 SER n 
1 611 THR n 
1 612 PRO n 
1 613 PHE n 
1 614 GLU n 
1 615 LEU n 
1 616 SER n 
1 617 GLY n 
1 618 ASN n 
1 619 ASN n 
1 620 LEU n 
1 621 GLN n 
1 622 ILE n 
1 623 GLY n 
1 624 VAL n 
1 625 THR n 
1 626 GLY n 
1 627 LEU n 
1 628 SER n 
1 629 ALA n 
1 630 GLY n 
1 631 ASP n 
1 632 LYS n 
1 633 VAL n 
1 634 TYR n 
1 635 ILE n 
1 636 ASP n 
1 637 LYS n 
1 638 ILE n 
1 639 GLU n 
1 640 PHE n 
1 641 ILE n 
1 642 PRO n 
1 643 VAL n 
1 644 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   644 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'cry3Aa, EEL55_22485' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Bacillus thuringiensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1428 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Bacillus thuringiensis' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     1428 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   PRO 3   3   ?   ?   ?   A . n 
A 1 4   ASN 4   4   ?   ?   ?   A . n 
A 1 5   ASN 5   5   ?   ?   ?   A . n 
A 1 6   ARG 6   6   ?   ?   ?   A . n 
A 1 7   SER 7   7   ?   ?   ?   A . n 
A 1 8   GLU 8   8   ?   ?   ?   A . n 
A 1 9   HIS 9   9   ?   ?   ?   A . n 
A 1 10  ASP 10  10  ?   ?   ?   A . n 
A 1 11  THR 11  11  ?   ?   ?   A . n 
A 1 12  ILE 12  12  ?   ?   ?   A . n 
A 1 13  LYS 13  13  ?   ?   ?   A . n 
A 1 14  THR 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  GLU 16  16  ?   ?   ?   A . n 
A 1 17  ASN 17  17  ?   ?   ?   A . n 
A 1 18  ASN 18  18  ?   ?   ?   A . n 
A 1 19  GLU 19  19  ?   ?   ?   A . n 
A 1 20  VAL 20  20  ?   ?   ?   A . n 
A 1 21  PRO 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  ASN 23  23  ?   ?   ?   A . n 
A 1 24  HIS 24  24  ?   ?   ?   A . n 
A 1 25  VAL 25  25  ?   ?   ?   A . n 
A 1 26  GLN 26  26  ?   ?   ?   A . n 
A 1 27  TYR 27  27  ?   ?   ?   A . n 
A 1 28  PRO 28  28  ?   ?   ?   A . n 
A 1 29  LEU 29  29  ?   ?   ?   A . n 
A 1 30  ALA 30  30  ?   ?   ?   A . n 
A 1 31  GLU 31  31  ?   ?   ?   A . n 
A 1 32  THR 32  32  ?   ?   ?   A . n 
A 1 33  PRO 33  33  ?   ?   ?   A . n 
A 1 34  ASN 34  34  ?   ?   ?   A . n 
A 1 35  PRO 35  35  ?   ?   ?   A . n 
A 1 36  THR 36  36  ?   ?   ?   A . n 
A 1 37  LEU 37  37  ?   ?   ?   A . n 
A 1 38  GLU 38  38  ?   ?   ?   A . n 
A 1 39  ASP 39  39  ?   ?   ?   A . n 
A 1 40  LEU 40  40  ?   ?   ?   A . n 
A 1 41  ASN 41  41  ?   ?   ?   A . n 
A 1 42  TYR 42  42  ?   ?   ?   A . n 
A 1 43  LYS 43  43  ?   ?   ?   A . n 
A 1 44  GLU 44  44  ?   ?   ?   A . n 
A 1 45  PHE 45  45  ?   ?   ?   A . n 
A 1 46  LEU 46  46  ?   ?   ?   A . n 
A 1 47  ARG 47  47  ?   ?   ?   A . n 
A 1 48  MET 48  48  ?   ?   ?   A . n 
A 1 49  THR 49  49  ?   ?   ?   A . n 
A 1 50  ALA 50  50  ?   ?   ?   A . n 
A 1 51  ASP 51  51  ?   ?   ?   A . n 
A 1 52  ASN 52  52  ?   ?   ?   A . n 
A 1 53  ASN 53  53  ?   ?   ?   A . n 
A 1 54  THR 54  54  ?   ?   ?   A . n 
A 1 55  GLU 55  55  ?   ?   ?   A . n 
A 1 56  ALA 56  56  ?   ?   ?   A . n 
A 1 57  LEU 57  57  ?   ?   ?   A . n 
A 1 58  ASP 58  58  ?   ?   ?   A . n 
A 1 59  SER 59  59  ?   ?   ?   A . n 
A 1 60  SER 60  60  ?   ?   ?   A . n 
A 1 61  THR 61  61  61  THR THR A . n 
A 1 62  THR 62  62  62  THR THR A . n 
A 1 63  LYS 63  63  63  LYS LYS A . n 
A 1 64  ASP 64  64  64  ASP ASP A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  ILE 66  66  66  ILE ILE A . n 
A 1 67  GLN 67  67  67  GLN GLN A . n 
A 1 68  LYS 68  68  68  LYS LYS A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLY 74  74  74  GLY GLY A . n 
A 1 75  ASP 75  75  75  ASP ASP A . n 
A 1 76  LEU 76  76  76  LEU LEU A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  GLY 78  78  78  GLY GLY A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  VAL 80  80  80  VAL VAL A . n 
A 1 81  GLY 81  81  81  GLY GLY A . n 
A 1 82  PHE 82  82  82  PHE PHE A . n 
A 1 83  PRO 83  83  83  PRO PRO A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  LEU 88  88  88  LEU LEU A . n 
A 1 89  VAL 89  89  89  VAL VAL A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  PHE 91  91  91  PHE PHE A . n 
A 1 92  TYR 92  92  92  TYR TYR A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  PHE 95  95  95  PHE PHE A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  ASN 97  97  97  ASN ASN A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  ILE 99  99  99  ILE ILE A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 PRO 101 101 101 PRO PRO A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 ASP 104 104 104 ASP ASP A . n 
A 1 105 PRO 105 105 105 PRO PRO A . n 
A 1 106 TRP 106 106 106 TRP TRP A . n 
A 1 107 LYS 107 107 107 LYS LYS A . n 
A 1 108 ALA 108 108 108 ALA ALA A . n 
A 1 109 PHE 109 109 109 PHE PHE A . n 
A 1 110 MET 110 110 110 MET MET A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 GLN 112 112 112 GLN GLN A . n 
A 1 113 VAL 113 113 113 VAL VAL A . n 
A 1 114 GLU 114 114 114 GLU GLU A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 MET 117 117 117 MET MET A . n 
A 1 118 ASP 118 118 118 ASP ASP A . n 
A 1 119 GLN 119 119 119 GLN GLN A . n 
A 1 120 LYS 120 120 120 LYS LYS A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 ALA 122 122 122 ALA ALA A . n 
A 1 123 ASP 123 123 123 ASP ASP A . n 
A 1 124 TYR 124 124 124 TYR TYR A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 LYS 126 126 126 LYS LYS A . n 
A 1 127 ASN 127 127 127 ASN ASN A . n 
A 1 128 LYS 128 128 128 LYS LYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 GLU 132 132 132 GLU GLU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 GLN 134 134 134 GLN GLN A . n 
A 1 135 GLY 135 135 135 GLY GLY A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 GLN 137 137 137 GLN GLN A . n 
A 1 138 ASN 138 138 138 ASN ASN A . n 
A 1 139 ASN 139 139 139 ASN ASN A . n 
A 1 140 VAL 140 140 140 VAL VAL A . n 
A 1 141 GLU 141 141 141 GLU GLU A . n 
A 1 142 ASP 142 142 142 ASP ASP A . n 
A 1 143 TYR 143 143 143 TYR TYR A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 SER 148 148 148 SER SER A . n 
A 1 149 SER 149 149 149 SER SER A . n 
A 1 150 TRP 150 150 150 TRP TRP A . n 
A 1 151 GLN 151 151 151 GLN GLN A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 ASN 153 153 153 ASN ASN A . n 
A 1 154 PRO 154 154 154 PRO PRO A . n 
A 1 155 VAL 155 155 155 VAL VAL A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 SER 157 157 157 SER SER A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 ASN 159 159 159 ASN ASN A . n 
A 1 160 PRO 160 160 160 PRO PRO A . n 
A 1 161 HIS 161 161 161 HIS HIS A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 GLN 163 163 163 GLN GLN A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 ARG 165 165 165 ARG ARG A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 ARG 167 167 167 ARG ARG A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 LEU 169 169 169 LEU LEU A . n 
A 1 170 PHE 170 170 170 PHE PHE A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLU 174 174 174 GLU GLU A . n 
A 1 175 SER 175 175 175 SER SER A . n 
A 1 176 HIS 176 176 176 HIS HIS A . n 
A 1 177 PHE 177 177 177 PHE PHE A . n 
A 1 178 ARG 178 178 178 ARG ARG A . n 
A 1 179 ASN 179 179 179 ASN ASN A . n 
A 1 180 SER 180 180 180 SER SER A . n 
A 1 181 MET 181 181 181 MET MET A . n 
A 1 182 PRO 182 182 182 PRO PRO A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 ALA 185 185 185 ALA ALA A . n 
A 1 186 ILE 186 186 186 ILE ILE A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 TYR 189 189 189 TYR TYR A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 PHE 193 193 193 PHE PHE A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 TYR 197 197 197 TYR TYR A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 GLN 199 199 199 GLN GLN A . n 
A 1 200 ALA 200 200 200 ALA ALA A . n 
A 1 201 ALA 201 201 201 ALA ALA A . n 
A 1 202 ASN 202 202 202 ASN ASN A . n 
A 1 203 THR 203 203 203 THR THR A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 PHE 206 206 206 PHE PHE A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 LYS 209 209 209 LYS LYS A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 GLN 212 212 212 GLN GLN A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 TYR 214 214 214 TYR TYR A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 GLU 216 216 216 GLU GLU A . n 
A 1 217 GLU 217 217 217 GLU GLU A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 TYR 220 220 220 TYR TYR A . n 
A 1 221 GLU 221 221 221 GLU GLU A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 ASP 224 224 224 ASP ASP A . n 
A 1 225 ILE 225 225 225 ILE ILE A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 PHE 228 228 228 PHE PHE A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 LYS 230 230 230 LYS LYS A . n 
A 1 231 ARG 231 231 231 ARG ARG A . n 
A 1 232 GLN 232 232 232 GLN GLN A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 LYS 234 234 234 LYS LYS A . n 
A 1 235 LEU 235 235 235 LEU LEU A . n 
A 1 236 THR 236 236 236 THR THR A . n 
A 1 237 GLN 237 237 237 GLN GLN A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 THR 240 240 240 THR THR A . n 
A 1 241 ASP 241 241 241 ASP ASP A . n 
A 1 242 HIS 242 242 242 HIS HIS A . n 
A 1 243 CYS 243 243 243 CYS CYS A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 LYS 245 245 245 LYS LYS A . n 
A 1 246 TRP 246 246 246 TRP TRP A . n 
A 1 247 TYR 247 247 247 TYR TYR A . n 
A 1 248 ASN 248 248 248 ASN ASN A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 GLY 250 250 250 GLY GLY A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 ASP 252 252 252 ASP ASP A . n 
A 1 253 LYS 253 253 253 LYS LYS A . n 
A 1 254 LEU 254 254 254 LEU LEU A . n 
A 1 255 ARG 255 255 255 ARG ARG A . n 
A 1 256 GLY 256 256 256 GLY GLY A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 SER 258 258 258 SER SER A . n 
A 1 259 TYR 259 259 259 TYR TYR A . n 
A 1 260 GLU 260 260 260 GLU GLU A . n 
A 1 261 SER 261 261 261 SER SER A . n 
A 1 262 TRP 262 262 262 TRP TRP A . n 
A 1 263 VAL 263 263 263 VAL VAL A . n 
A 1 264 ASN 264 264 264 ASN ASN A . n 
A 1 265 PHE 265 265 265 PHE PHE A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 TYR 268 268 268 TYR TYR A . n 
A 1 269 ARG 269 269 269 ARG ARG A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 GLU 271 271 271 GLU GLU A . n 
A 1 272 MET 272 272 272 MET MET A . n 
A 1 273 THR 273 273 273 THR THR A . n 
A 1 274 LEU 274 274 274 LEU LEU A . n 
A 1 275 THR 275 275 275 THR THR A . n 
A 1 276 VAL 276 276 276 VAL VAL A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 ASP 278 278 278 ASP ASP A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 ILE 280 280 280 ILE ILE A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 PHE 283 283 283 PHE PHE A . n 
A 1 284 PRO 284 284 284 PRO PRO A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 TYR 286 286 286 TYR TYR A . n 
A 1 287 ASP 287 287 287 ASP ASP A . n 
A 1 288 VAL 288 288 288 VAL VAL A . n 
A 1 289 ARG 289 289 289 ARG ARG A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 TYR 291 291 291 TYR TYR A . n 
A 1 292 PRO 292 292 292 PRO PRO A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 GLU 294 294 294 GLU GLU A . n 
A 1 295 VAL 295 295 295 VAL VAL A . n 
A 1 296 LYS 296 296 296 LYS LYS A . n 
A 1 297 THR 297 297 297 THR THR A . n 
A 1 298 GLU 298 298 298 GLU GLU A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 THR 300 300 300 THR THR A . n 
A 1 301 ARG 301 301 301 ARG ARG A . n 
A 1 302 ASP 302 302 302 ASP ASP A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 THR 305 305 305 THR THR A . n 
A 1 306 ASP 306 306 306 ASP ASP A . n 
A 1 307 PRO 307 307 307 PRO PRO A . n 
A 1 308 ILE 308 308 308 ILE ILE A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 GLY 310 310 310 GLY GLY A . n 
A 1 311 VAL 311 311 311 VAL VAL A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 ASN 313 313 313 ASN ASN A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 ARG 315 315 315 ARG ARG A . n 
A 1 316 GLY 316 316 316 GLY GLY A . n 
A 1 317 TYR 317 317 317 TYR TYR A . n 
A 1 318 GLY 318 318 318 GLY GLY A . n 
A 1 319 THR 319 319 319 THR THR A . n 
A 1 320 THR 320 320 320 THR THR A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 SER 322 322 322 SER SER A . n 
A 1 323 ASN 323 323 323 ASN ASN A . n 
A 1 324 ILE 324 324 324 ILE ILE A . n 
A 1 325 GLU 325 325 325 GLU GLU A . n 
A 1 326 ASN 326 326 326 ASN ASN A . n 
A 1 327 TYR 327 327 327 TYR TYR A . n 
A 1 328 ILE 328 328 328 ILE ILE A . n 
A 1 329 ARG 329 329 329 ARG ARG A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 PRO 331 331 331 PRO PRO A . n 
A 1 332 HIS 332 332 332 HIS HIS A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 PHE 334 334 334 PHE PHE A . n 
A 1 335 ASP 335 335 335 ASP ASP A . n 
A 1 336 TYR 336 336 336 TYR TYR A . n 
A 1 337 LEU 337 337 337 LEU LEU A . n 
A 1 338 HIS 338 338 338 HIS HIS A . n 
A 1 339 ARG 339 339 339 ARG ARG A . n 
A 1 340 ILE 340 340 340 ILE ILE A . n 
A 1 341 GLN 341 341 341 GLN GLN A . n 
A 1 342 PHE 342 342 342 PHE PHE A . n 
A 1 343 HIS 343 343 343 HIS HIS A . n 
A 1 344 THR 344 344 344 THR THR A . n 
A 1 345 ARG 345 345 345 ARG ARG A . n 
A 1 346 PHE 346 346 346 PHE PHE A . n 
A 1 347 GLN 347 347 347 GLN GLN A . n 
A 1 348 PRO 348 348 348 PRO PRO A . n 
A 1 349 GLY 349 349 349 GLY GLY A . n 
A 1 350 TYR 350 350 350 TYR TYR A . n 
A 1 351 TYR 351 351 351 TYR TYR A . n 
A 1 352 GLY 352 352 352 GLY GLY A . n 
A 1 353 ASN 353 353 353 ASN ASN A . n 
A 1 354 ASP 354 354 354 ASP ASP A . n 
A 1 355 SER 355 355 355 SER SER A . n 
A 1 356 PHE 356 356 356 PHE PHE A . n 
A 1 357 ASN 357 357 357 ASN ASN A . n 
A 1 358 TYR 358 358 358 TYR TYR A . n 
A 1 359 TRP 359 359 359 TRP TRP A . n 
A 1 360 SER 360 360 360 SER SER A . n 
A 1 361 GLY 361 361 361 GLY GLY A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 TYR 363 363 363 TYR TYR A . n 
A 1 364 VAL 364 364 364 VAL VAL A . n 
A 1 365 SER 365 365 365 SER SER A . n 
A 1 366 THR 366 366 366 THR THR A . n 
A 1 367 ARG 367 367 367 ARG ARG A . n 
A 1 368 PRO 368 368 368 PRO PRO A . n 
A 1 369 SER 369 369 369 SER SER A . n 
A 1 370 ILE 370 370 370 ILE ILE A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 SER 372 372 372 SER SER A . n 
A 1 373 ASN 373 373 373 ASN ASN A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 THR 377 377 377 THR THR A . n 
A 1 378 SER 378 378 378 SER SER A . n 
A 1 379 PRO 379 379 379 PRO PRO A . n 
A 1 380 PHE 380 380 380 PHE PHE A . n 
A 1 381 TYR 381 381 381 TYR TYR A . n 
A 1 382 GLY 382 382 382 GLY GLY A . n 
A 1 383 ASN 383 383 383 ASN ASN A . n 
A 1 384 LYS 384 384 384 LYS LYS A . n 
A 1 385 SER 385 385 385 SER SER A . n 
A 1 386 SER 386 386 386 SER SER A . n 
A 1 387 GLU 387 387 387 GLU GLU A . n 
A 1 388 PRO 388 388 388 PRO PRO A . n 
A 1 389 VAL 389 389 389 VAL VAL A . n 
A 1 390 GLN 390 390 390 GLN GLN A . n 
A 1 391 ASN 391 391 391 ASN ASN A . n 
A 1 392 LEU 392 392 392 LEU LEU A . n 
A 1 393 GLU 393 393 393 GLU GLU A . n 
A 1 394 PHE 394 394 394 PHE PHE A . n 
A 1 395 ASN 395 395 395 ASN ASN A . n 
A 1 396 GLY 396 396 396 GLY GLY A . n 
A 1 397 GLU 397 397 397 GLU GLU A . n 
A 1 398 LYS 398 398 398 LYS LYS A . n 
A 1 399 VAL 399 399 399 VAL VAL A . n 
A 1 400 TYR 400 400 400 TYR TYR A . n 
A 1 401 ARG 401 401 401 ARG ARG A . n 
A 1 402 ALA 402 402 402 ALA ALA A . n 
A 1 403 VAL 403 403 403 VAL VAL A . n 
A 1 404 ALA 404 404 404 ALA ALA A . n 
A 1 405 ASN 405 405 405 ASN ASN A . n 
A 1 406 THR 406 406 406 THR THR A . n 
A 1 407 ASN 407 407 407 ASN ASN A . n 
A 1 408 LEU 408 408 408 LEU LEU A . n 
A 1 409 ALA 409 409 409 ALA ALA A . n 
A 1 410 VAL 410 410 410 VAL VAL A . n 
A 1 411 TRP 411 411 411 TRP TRP A . n 
A 1 412 PRO 412 412 412 PRO PRO A . n 
A 1 413 SER 413 413 413 SER SER A . n 
A 1 414 ALA 414 414 414 ALA ALA A . n 
A 1 415 VAL 415 415 415 VAL VAL A . n 
A 1 416 TYR 416 416 416 TYR TYR A . n 
A 1 417 SER 417 417 417 SER SER A . n 
A 1 418 GLY 418 418 418 GLY GLY A . n 
A 1 419 VAL 419 419 419 VAL VAL A . n 
A 1 420 THR 420 420 420 THR THR A . n 
A 1 421 LYS 421 421 421 LYS LYS A . n 
A 1 422 VAL 422 422 422 VAL VAL A . n 
A 1 423 GLU 423 423 423 GLU GLU A . n 
A 1 424 PHE 424 424 424 PHE PHE A . n 
A 1 425 SER 425 425 425 SER SER A . n 
A 1 426 GLN 426 426 426 GLN GLN A . n 
A 1 427 TYR 427 427 427 TYR TYR A . n 
A 1 428 ASN 428 428 428 ASN ASN A . n 
A 1 429 ASP 429 429 429 ASP ASP A . n 
A 1 430 GLN 430 430 430 GLN GLN A . n 
A 1 431 THR 431 431 431 THR THR A . n 
A 1 432 ASP 432 432 432 ASP ASP A . n 
A 1 433 GLU 433 433 433 GLU GLU A . n 
A 1 434 ALA 434 434 434 ALA ALA A . n 
A 1 435 SER 435 435 435 SER SER A . n 
A 1 436 THR 436 436 436 THR THR A . n 
A 1 437 GLN 437 437 437 GLN GLN A . n 
A 1 438 THR 438 438 438 THR THR A . n 
A 1 439 TYR 439 439 439 TYR TYR A . n 
A 1 440 ASP 440 440 440 ASP ASP A . n 
A 1 441 SER 441 441 441 SER SER A . n 
A 1 442 LYS 442 442 442 LYS LYS A . n 
A 1 443 ARG 443 443 443 ARG ARG A . n 
A 1 444 ASN 444 444 444 ASN ASN A . n 
A 1 445 VAL 445 445 445 VAL VAL A . n 
A 1 446 GLY 446 446 446 GLY GLY A . n 
A 1 447 ALA 447 447 447 ALA ALA A . n 
A 1 448 VAL 448 448 448 VAL VAL A . n 
A 1 449 SER 449 449 449 SER SER A . n 
A 1 450 TRP 450 450 450 TRP TRP A . n 
A 1 451 ASP 451 451 451 ASP ASP A . n 
A 1 452 SER 452 452 452 SER SER A . n 
A 1 453 ILE 453 453 453 ILE ILE A . n 
A 1 454 ASP 454 454 454 ASP ASP A . n 
A 1 455 GLN 455 455 455 GLN GLN A . n 
A 1 456 LEU 456 456 456 LEU LEU A . n 
A 1 457 PRO 457 457 457 PRO PRO A . n 
A 1 458 PRO 458 458 458 PRO PRO A . n 
A 1 459 GLU 459 459 459 GLU GLU A . n 
A 1 460 THR 460 460 460 THR THR A . n 
A 1 461 THR 461 461 461 THR THR A . n 
A 1 462 ASP 462 462 462 ASP ASP A . n 
A 1 463 GLU 463 463 463 GLU GLU A . n 
A 1 464 PRO 464 464 464 PRO PRO A . n 
A 1 465 LEU 465 465 465 LEU LEU A . n 
A 1 466 GLU 466 466 466 GLU GLU A . n 
A 1 467 LYS 467 467 467 LYS LYS A . n 
A 1 468 GLY 468 468 468 GLY GLY A . n 
A 1 469 TYR 469 469 469 TYR TYR A . n 
A 1 470 SER 470 470 470 SER SER A . n 
A 1 471 HIS 471 471 471 HIS HIS A . n 
A 1 472 GLN 472 472 472 GLN GLN A . n 
A 1 473 LEU 473 473 473 LEU LEU A . n 
A 1 474 ASN 474 474 474 ASN ASN A . n 
A 1 475 TYR 475 475 475 TYR TYR A . n 
A 1 476 VAL 476 476 476 VAL VAL A . n 
A 1 477 MET 477 477 477 MET MET A . n 
A 1 478 CYS 478 478 478 CYS CYS A . n 
A 1 479 PHE 479 479 479 PHE PHE A . n 
A 1 480 LEU 480 480 480 LEU LEU A . n 
A 1 481 MET 481 481 481 MET MET A . n 
A 1 482 GLN 482 482 482 GLN GLN A . n 
A 1 483 GLY 483 483 483 GLY GLY A . n 
A 1 484 SER 484 484 484 SER SER A . n 
A 1 485 ARG 485 485 485 ARG ARG A . n 
A 1 486 GLY 486 486 486 GLY GLY A . n 
A 1 487 THR 487 487 487 THR THR A . n 
A 1 488 ILE 488 488 488 ILE ILE A . n 
A 1 489 PRO 489 489 489 PRO PRO A . n 
A 1 490 VAL 490 490 490 VAL VAL A . n 
A 1 491 LEU 491 491 491 LEU LEU A . n 
A 1 492 THR 492 492 492 THR THR A . n 
A 1 493 TRP 493 493 493 TRP TRP A . n 
A 1 494 THR 494 494 494 THR THR A . n 
A 1 495 HIS 495 495 495 HIS HIS A . n 
A 1 496 LYS 496 496 496 LYS LYS A . n 
A 1 497 SER 497 497 497 SER SER A . n 
A 1 498 VAL 498 498 498 VAL VAL A . n 
A 1 499 ASP 499 499 499 ASP ASP A . n 
A 1 500 PHE 500 500 500 PHE PHE A . n 
A 1 501 PHE 501 501 501 PHE PHE A . n 
A 1 502 ASN 502 502 502 ASN ASN A . n 
A 1 503 MET 503 503 503 MET MET A . n 
A 1 504 ILE 504 504 504 ILE ILE A . n 
A 1 505 ASP 505 505 505 ASP ASP A . n 
A 1 506 SER 506 506 506 SER SER A . n 
A 1 507 LYS 507 507 507 LYS LYS A . n 
A 1 508 LYS 508 508 508 LYS LYS A . n 
A 1 509 ILE 509 509 509 ILE ILE A . n 
A 1 510 THR 510 510 510 THR THR A . n 
A 1 511 GLN 511 511 511 GLN GLN A . n 
A 1 512 LEU 512 512 512 LEU LEU A . n 
A 1 513 PRO 513 513 513 PRO PRO A . n 
A 1 514 LEU 514 514 514 LEU LEU A . n 
A 1 515 VAL 515 515 515 VAL VAL A . n 
A 1 516 LYS 516 516 516 LYS LYS A . n 
A 1 517 ALA 517 517 517 ALA ALA A . n 
A 1 518 TYR 518 518 518 TYR TYR A . n 
A 1 519 LYS 519 519 519 LYS LYS A . n 
A 1 520 LEU 520 520 520 LEU LEU A . n 
A 1 521 GLN 521 521 521 GLN GLN A . n 
A 1 522 SER 522 522 522 SER SER A . n 
A 1 523 GLY 523 523 523 GLY GLY A . n 
A 1 524 ALA 524 524 524 ALA ALA A . n 
A 1 525 SER 525 525 525 SER SER A . n 
A 1 526 VAL 526 526 526 VAL VAL A . n 
A 1 527 VAL 527 527 527 VAL VAL A . n 
A 1 528 ALA 528 528 528 ALA ALA A . n 
A 1 529 GLY 529 529 529 GLY GLY A . n 
A 1 530 PRO 530 530 530 PRO PRO A . n 
A 1 531 ARG 531 531 531 ARG ARG A . n 
A 1 532 PHE 532 532 532 PHE PHE A . n 
A 1 533 THR 533 533 533 THR THR A . n 
A 1 534 GLY 534 534 534 GLY GLY A . n 
A 1 535 GLY 535 535 535 GLY GLY A . n 
A 1 536 ASP 536 536 536 ASP ASP A . n 
A 1 537 ILE 537 537 537 ILE ILE A . n 
A 1 538 ILE 538 538 538 ILE ILE A . n 
A 1 539 GLN 539 539 539 GLN GLN A . n 
A 1 540 CYS 540 540 540 CYS CYS A . n 
A 1 541 THR 541 541 541 THR THR A . n 
A 1 542 GLU 542 542 542 GLU GLU A . n 
A 1 543 ASN 543 543 543 ASN ASN A . n 
A 1 544 GLY 544 544 544 GLY GLY A . n 
A 1 545 SER 545 545 545 SER SER A . n 
A 1 546 ALA 546 546 546 ALA ALA A . n 
A 1 547 ALA 547 547 547 ALA ALA A . n 
A 1 548 THR 548 548 548 THR THR A . n 
A 1 549 ILE 549 549 549 ILE ILE A . n 
A 1 550 TYR 550 550 550 TYR TYR A . n 
A 1 551 VAL 551 551 551 VAL VAL A . n 
A 1 552 THR 552 552 552 THR THR A . n 
A 1 553 PRO 553 553 553 PRO PRO A . n 
A 1 554 ASP 554 554 554 ASP ASP A . n 
A 1 555 VAL 555 555 555 VAL VAL A . n 
A 1 556 SER 556 556 556 SER SER A . n 
A 1 557 TYR 557 557 557 TYR TYR A . n 
A 1 558 SER 558 558 558 SER SER A . n 
A 1 559 GLN 559 559 559 GLN GLN A . n 
A 1 560 LYS 560 560 560 LYS LYS A . n 
A 1 561 TYR 561 561 561 TYR TYR A . n 
A 1 562 ARG 562 562 562 ARG ARG A . n 
A 1 563 ALA 563 563 563 ALA ALA A . n 
A 1 564 ARG 564 564 564 ARG ARG A . n 
A 1 565 ILE 565 565 565 ILE ILE A . n 
A 1 566 HIS 566 566 566 HIS HIS A . n 
A 1 567 TYR 567 567 567 TYR TYR A . n 
A 1 568 ALA 568 568 568 ALA ALA A . n 
A 1 569 SER 569 569 569 SER SER A . n 
A 1 570 THR 570 570 570 THR THR A . n 
A 1 571 SER 571 571 571 SER SER A . n 
A 1 572 GLN 572 572 572 GLN GLN A . n 
A 1 573 ILE 573 573 573 ILE ILE A . n 
A 1 574 THR 574 574 574 THR THR A . n 
A 1 575 PHE 575 575 575 PHE PHE A . n 
A 1 576 THR 576 576 576 THR THR A . n 
A 1 577 LEU 577 577 577 LEU LEU A . n 
A 1 578 SER 578 578 578 SER SER A . n 
A 1 579 LEU 579 579 579 LEU LEU A . n 
A 1 580 ASP 580 580 580 ASP ASP A . n 
A 1 581 GLY 581 581 581 GLY GLY A . n 
A 1 582 ALA 582 582 582 ALA ALA A . n 
A 1 583 PRO 583 583 583 PRO PRO A . n 
A 1 584 PHE 584 584 584 PHE PHE A . n 
A 1 585 ASN 585 585 585 ASN ASN A . n 
A 1 586 GLN 586 586 586 GLN GLN A . n 
A 1 587 TYR 587 587 587 TYR TYR A . n 
A 1 588 TYR 588 588 588 TYR TYR A . n 
A 1 589 PHE 589 589 589 PHE PHE A . n 
A 1 590 ASP 590 590 590 ASP ASP A . n 
A 1 591 LYS 591 591 591 LYS LYS A . n 
A 1 592 THR 592 592 592 THR THR A . n 
A 1 593 ILE 593 593 593 ILE ILE A . n 
A 1 594 ASN 594 594 594 ASN ASN A . n 
A 1 595 LYS 595 595 595 LYS LYS A . n 
A 1 596 GLY 596 596 596 GLY GLY A . n 
A 1 597 ASP 597 597 597 ASP ASP A . n 
A 1 598 THR 598 598 598 THR THR A . n 
A 1 599 LEU 599 599 599 LEU LEU A . n 
A 1 600 THR 600 600 600 THR THR A . n 
A 1 601 TYR 601 601 601 TYR TYR A . n 
A 1 602 ASN 602 602 602 ASN ASN A . n 
A 1 603 SER 603 603 603 SER SER A . n 
A 1 604 PHE 604 604 604 PHE PHE A . n 
A 1 605 ASN 605 605 605 ASN ASN A . n 
A 1 606 LEU 606 606 606 LEU LEU A . n 
A 1 607 ALA 607 607 607 ALA ALA A . n 
A 1 608 SER 608 608 608 SER SER A . n 
A 1 609 PHE 609 609 609 PHE PHE A . n 
A 1 610 SER 610 610 610 SER SER A . n 
A 1 611 THR 611 611 611 THR THR A . n 
A 1 612 PRO 612 612 612 PRO PRO A . n 
A 1 613 PHE 613 613 613 PHE PHE A . n 
A 1 614 GLU 614 614 614 GLU GLU A . n 
A 1 615 LEU 615 615 615 LEU LEU A . n 
A 1 616 SER 616 616 616 SER SER A . n 
A 1 617 GLY 617 617 617 GLY GLY A . n 
A 1 618 ASN 618 618 618 ASN ASN A . n 
A 1 619 ASN 619 619 619 ASN ASN A . n 
A 1 620 LEU 620 620 620 LEU LEU A . n 
A 1 621 GLN 621 621 621 GLN GLN A . n 
A 1 622 ILE 622 622 622 ILE ILE A . n 
A 1 623 GLY 623 623 623 GLY GLY A . n 
A 1 624 VAL 624 624 624 VAL VAL A . n 
A 1 625 THR 625 625 625 THR THR A . n 
A 1 626 GLY 626 626 626 GLY GLY A . n 
A 1 627 LEU 627 627 627 LEU LEU A . n 
A 1 628 SER 628 628 628 SER SER A . n 
A 1 629 ALA 629 629 629 ALA ALA A . n 
A 1 630 GLY 630 630 630 GLY GLY A . n 
A 1 631 ASP 631 631 631 ASP ASP A . n 
A 1 632 LYS 632 632 632 LYS LYS A . n 
A 1 633 VAL 633 633 633 VAL VAL A . n 
A 1 634 TYR 634 634 634 TYR TYR A . n 
A 1 635 ILE 635 635 635 ILE ILE A . n 
A 1 636 ASP 636 636 636 ASP ASP A . n 
A 1 637 LYS 637 637 637 LYS LYS A . n 
A 1 638 ILE 638 638 638 ILE ILE A . n 
A 1 639 GLU 639 639 639 GLU GLU A . n 
A 1 640 PHE 640 640 640 PHE PHE A . n 
A 1 641 ILE 641 641 641 ILE ILE A . n 
A 1 642 PRO 642 642 642 PRO PRO A . n 
A 1 643 VAL 643 643 643 VAL VAL A . n 
A 1 644 ASN 644 644 644 ASN ASN A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1 701 4 HOH HOH A . 
B 2 HOH 2 702 3 HOH HOH A . 
B 2 HOH 3 703 1 HOH HOH A . 
B 2 HOH 4 704 2 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? '(1.18_3861)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .             2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .             3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .             4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YQH 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     115.846 
_cell.length_a_esd                 ? 
_cell.length_b                     133.368 
_cell.length_b_esd                 ? 
_cell.length_c                     105.798 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YQH 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YQH 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.79 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.86 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;Cry3Aa crystals obatined in conditon: 100 mM HEPES/NaOH pH7.5, 20% v/v 1,4-butanediol, 200 mM NaCl.
Then the Cry3Aa crystals soaked with 50ug/ml PEI, 5mM EDC and 10 mM NHS at 291K overnight.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RAYONIX MX300-HS' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE TPS 05A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'TPS 05A' 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YQH 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.10 
_reflns.d_resolution_low                               20.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     15017 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          3.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.740 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.202 
_reflns.pdbx_Rpim_I_all                                0.056 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       194996 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.980 
_reflns.pdbx_CC_star                                   0.995 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.194 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
3.10 3.15  ? ? ? ? ? ? 752 ? ? ? ? ? ? ? ? ? ? ? 13.3 0.428 ? ? 0.869 0.236 ? 1  1 0.837 0.955 ? 100.0 ? 0.836 ? ? ? ? ? ? ? ? ? 
3.15 3.21  ? ? ? ? ? ? 739 ? ? ? ? ? ? ? ? ? ? ? 12.8 0.435 ? ? 0.788 0.219 ? 2  1 0.860 0.962 ? 99.6  ? 0.756 ? ? ? ? ? ? ? ? ? 
3.21 3.27  ? ? ? ? ? ? 744 ? ? ? ? ? ? ? ? ? ? ? 12.3 0.443 ? ? 0.647 0.184 ? 3  1 0.894 0.972 ? 99.9  ? 0.620 ? ? ? ? ? ? ? ? ? 
3.27 3.34  ? ? ? ? ? ? 722 ? ? ? ? ? ? ? ? ? ? ? 12.8 0.476 ? ? 0.544 0.151 ? 4  1 0.938 0.984 ? 99.6  ? 0.522 ? ? ? ? ? ? ? ? ? 
3.34 3.41  ? ? ? ? ? ? 752 ? ? ? ? ? ? ? ? ? ? ? 13.2 0.639 ? ? 0.679 0.187 ? 5  1 0.917 0.978 ? 99.9  ? 0.652 ? ? ? ? ? ? ? ? ? 
3.41 3.49  ? ? ? ? ? ? 722 ? ? ? ? ? ? ? ? ? ? ? 12.5 1.247 ? ? 0.634 0.186 ? 6  1 0.979 0.995 ? 99.7  ? 0.605 ? ? ? ? ? ? ? ? ? 
3.49 3.58  ? ? ? ? ? ? 735 ? ? ? ? ? ? ? ? ? ? ? 14.1 0.586 ? ? 0.377 0.099 ? 7  1 0.969 0.992 ? 100.0 ? 0.364 ? ? ? ? ? ? ? ? ? 
3.58 3.67  ? ? ? ? ? ? 759 ? ? ? ? ? ? ? ? ? ? ? 12.9 1.229 ? ? 0.467 0.129 ? 8  1 0.939 0.984 ? 99.9  ? 0.448 ? ? ? ? ? ? ? ? ? 
3.67 3.78  ? ? ? ? ? ? 733 ? ? ? ? ? ? ? ? ? ? ? 13.6 0.652 ? ? 0.339 0.091 ? 9  1 0.982 0.995 ? 100.0 ? 0.326 ? ? ? ? ? ? ? ? ? 
3.78 3.90  ? ? ? ? ? ? 744 ? ? ? ? ? ? ? ? ? ? ? 12.4 1.444 ? ? 0.372 0.108 ? 10 1 0.972 0.993 ? 99.6  ? 0.356 ? ? ? ? ? ? ? ? ? 
3.90 4.04  ? ? ? ? ? ? 748 ? ? ? ? ? ? ? ? ? ? ? 13.1 0.665 ? ? 0.236 0.065 ? 11 1 0.989 0.997 ? 100.0 ? 0.227 ? ? ? ? ? ? ? ? ? 
4.04 4.20  ? ? ? ? ? ? 742 ? ? ? ? ? ? ? ? ? ? ? 13.7 0.646 ? ? 0.170 0.045 ? 12 1 0.992 0.998 ? 100.0 ? 0.163 ? ? ? ? ? ? ? ? ? 
4.20 4.39  ? ? ? ? ? ? 749 ? ? ? ? ? ? ? ? ? ? ? 13.5 0.702 ? ? 0.138 0.037 ? 13 1 0.995 0.999 ? 100.0 ? 0.133 ? ? ? ? ? ? ? ? ? 
4.39 4.62  ? ? ? ? ? ? 766 ? ? ? ? ? ? ? ? ? ? ? 13.1 0.757 ? ? 0.120 0.033 ? 14 1 0.996 0.999 ? 100.0 ? 0.116 ? ? ? ? ? ? ? ? ? 
4.62 4.90  ? ? ? ? ? ? 745 ? ? ? ? ? ? ? ? ? ? ? 12.9 0.731 ? ? 0.111 0.031 ? 15 1 0.996 0.999 ? 100.0 ? 0.106 ? ? ? ? ? ? ? ? ? 
4.90 5.27  ? ? ? ? ? ? 754 ? ? ? ? ? ? ? ? ? ? ? 11.6 0.700 ? ? 0.111 0.032 ? 16 1 0.996 0.999 ? 100.0 ? 0.106 ? ? ? ? ? ? ? ? ? 
5.27 5.79  ? ? ? ? ? ? 762 ? ? ? ? ? ? ? ? ? ? ? 12.8 0.645 ? ? 0.110 0.031 ? 17 1 0.997 0.999 ? 99.7  ? 0.106 ? ? ? ? ? ? ? ? ? 
5.79 6.61  ? ? ? ? ? ? 761 ? ? ? ? ? ? ? ? ? ? ? 12.7 0.671 ? ? 0.106 0.029 ? 18 1 0.996 0.999 ? 100.0 ? 0.102 ? ? ? ? ? ? ? ? ? 
6.61 8.23  ? ? ? ? ? ? 779 ? ? ? ? ? ? ? ? ? ? ? 13.1 0.761 ? ? 0.079 0.022 ? 19 1 0.998 0.999 ? 100.0 ? 0.076 ? ? ? ? ? ? ? ? ? 
8.23 20.00 ? ? ? ? ? ? 809 ? ? ? ? ? ? ? ? ? ? ? 13.3 0.968 ? ? 0.057 0.016 ? 20 1 0.998 1.000 ? 100.0 ? 0.054 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YQH 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.11 
_refine.ls_d_res_low                             19.87 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     14992 
_refine.ls_number_reflns_R_free                  814 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.48 
_refine.ls_percent_reflns_R_free                 5.43 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1970 
_refine.ls_R_factor_R_free                       0.2754 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1926 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      1DLC 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.23 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.36 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.11 
_refine_hist.d_res_low                        19.87 
_refine_hist.number_atoms_solvent             4 
_refine_hist.number_atoms_total               4694 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4690 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  ? 4820 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.274  ? 6555 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 10.138 ? 644  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.063  ? 707  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007  ? 848  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.11 3.30  . . 118 2298 98.00  . . . . 0.2181 . . . . . . . . . . . 0.2976 
'X-RAY DIFFRACTION' 3.30 3.55  . . 148 2325 100.00 . . . . 0.2341 . . . . . . . . . . . 0.3015 
'X-RAY DIFFRACTION' 3.55 3.91  . . 125 2343 100.00 . . . . 0.2319 . . . . . . . . . . . 0.3717 
'X-RAY DIFFRACTION' 3.91 4.47  . . 134 2377 100.00 . . . . 0.1827 . . . . . . . . . . . 0.2340 
'X-RAY DIFFRACTION' 4.47 5.61  . . 142 2372 100.00 . . . . 0.1641 . . . . . . . . . . . 0.2507 
'X-RAY DIFFRACTION' 5.61 19.87 . . 147 2463 100.00 . . . . 0.1736 . . . . . . . . . . . 0.2548 
# 
_struct.entry_id                     8YQH 
_struct.title                        'Crystal structure of Cry3Aa-PEI at 3.1 A' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YQH 
_struct_keywords.text            'Bacillus thuringiensis, crystal protein, insecticidal protein, TOXIN' 
_struct_keywords.pdbx_keywords   TOXIN 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q9S6N9_BACTU 
_struct_ref.pdbx_db_accession          Q9S6N9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MNPNNRSEHDTIKTTENNEVPTNHVQYPLAETPNPTLEDLNYKEFLRMTADNNTEALDSSTTKDVIQKGISVVGDLLGVV
GFPFGGALVSFYTNFLNTIWPSEDPWKAFMEQVEALMDQKIADYAKNKALAELQGLQNNVEDYVSALSSWQKNPVSSRNP
HSQGRIRELFSQAESHFRNSMPSFAISGYEVLFLTTYAQAANTHLFLLKDAQIYGEEWGYEKEDIAEFYKRQLKLTQEYT
DHCVKWYNVGLDKLRGSSYESWVNFNRYRREMTLTVLDLIALFPLYDVRLYPKEVKTELTRDVLTDPIVGVNNLRGYGTT
FSNIENYIRKPHLFDYLHRIQFHTRFQPGYYGNDSFNYWSGNYVSTRPSIGSNDIITSPFYGNKSSEPVQNLEFNGEKVY
RAVANTNLAVWPSAVYSGVTKVEFSQYNDQTDEASTQTYDSKRNVGAVSWDSIDQLPPETTDEPLEKGYSHQLNYVMCFL
MQGSRGTIPVLTWTHKSVDFFNMIDSKKITQLPLVKAYKLQSGASVVAGPRFTGGDIIQCTENGSAATIYVTPDVSYSQK
YRARIHYASTSQITFTLSLDGAPFNQYYFDKTINKGDTLTYNSFNLASFSTPFELSGNNLQIGVTGLSAGDKVYIDKIEF
IPVN
;
_struct_ref.pdbx_align_begin           9 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YQH 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 644 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9S6N9 
_struct_ref_seq.db_align_beg                  9 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  652 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       644 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 64  ? LEU A 77  ? ASP A 64  LEU A 77  1 ? 14 
HELX_P HELX_P2  AA2 PHE A 84  ? ILE A 99  ? PHE A 84  ILE A 99  1 ? 16 
HELX_P HELX_P3  AA3 PRO A 105 ? ASP A 118 ? PRO A 105 ASP A 118 1 ? 14 
HELX_P HELX_P4  AA4 ALA A 122 ? ASN A 127 ? ALA A 122 ASN A 127 1 ? 6  
HELX_P HELX_P5  AA5 ALA A 129 ? ASN A 153 ? ALA A 129 ASN A 153 1 ? 25 
HELX_P HELX_P6  AA6 ASN A 159 ? MET A 181 ? ASN A 159 MET A 181 1 ? 23 
HELX_P HELX_P7  AA7 PRO A 182 ? ALA A 185 ? PRO A 182 ALA A 185 5 ? 4  
HELX_P HELX_P8  AA8 PHE A 193 ? GLY A 219 ? PHE A 193 GLY A 219 1 ? 27 
HELX_P HELX_P9  AA9 GLU A 221 ? LYS A 253 ? GLU A 221 LYS A 253 1 ? 33 
HELX_P HELX_P10 AB1 SER A 258 ? VAL A 276 ? SER A 258 VAL A 276 1 ? 19 
HELX_P HELX_P11 AB2 VAL A 276 ? ALA A 281 ? VAL A 276 ALA A 281 1 ? 6  
HELX_P HELX_P12 AB3 LEU A 282 ? ASP A 287 ? LEU A 282 ASP A 287 5 ? 6  
HELX_P HELX_P13 AB4 THR A 320 ? ASN A 326 ? THR A 320 ASN A 326 1 ? 7  
HELX_P HELX_P14 AB5 ILE A 453 ? GLN A 455 ? ILE A 453 GLN A 455 5 ? 3  
HELX_P HELX_P15 AB6 PRO A 464 ? TYR A 469 ? PRO A 464 TYR A 469 1 ? 6  
HELX_P HELX_P16 AB7 VAL A 515 ? ALA A 517 ? VAL A 515 ALA A 517 5 ? 3  
HELX_P HELX_P17 AB8 THR A 600 ? PHE A 604 ? THR A 600 PHE A 604 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 3 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 2 ? 
AA8 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? parallel      
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 295 ? LYS A 296 ? VAL A 295 LYS A 296 
AA1 2 ILE A 509 ? PRO A 513 ? ILE A 509 PRO A 513 
AA1 3 VAL A 633 ? PRO A 642 ? VAL A 633 PRO A 642 
AA1 4 LYS A 560 ? SER A 569 ? LYS A 560 SER A 569 
AA1 5 ASN A 605 ? SER A 608 ? ASN A 605 SER A 608 
AA2 1 ALA A 524 ? VAL A 527 ? ALA A 524 VAL A 527 
AA2 2 ILE A 537 ? CYS A 540 ? ILE A 537 CYS A 540 
AA2 3 VAL A 633 ? PRO A 642 ? VAL A 633 PRO A 642 
AA2 4 LYS A 560 ? SER A 569 ? LYS A 560 SER A 569 
AA2 5 PHE A 613 ? GLU A 614 ? PHE A 613 GLU A 614 
AA3 1 VAL A 303 ? LEU A 304 ? VAL A 303 LEU A 304 
AA3 2 THR A 487 ? HIS A 495 ? THR A 487 HIS A 495 
AA3 3 HIS A 471 ? LEU A 480 ? HIS A 471 LEU A 480 
AA4 1 ILE A 376 ? THR A 377 ? ILE A 376 THR A 377 
AA4 2 PHE A 356 ? PRO A 368 ? PHE A 356 PRO A 368 
AA4 3 TYR A 381 ? GLY A 382 ? TYR A 381 GLY A 382 
AA5 1 ILE A 376 ? THR A 377 ? ILE A 376 THR A 377 
AA5 2 PHE A 356 ? PRO A 368 ? PHE A 356 PRO A 368 
AA5 3 ASP A 335 ? GLN A 347 ? ASP A 335 GLN A 347 
AA5 4 GLN A 390 ? GLU A 393 ? GLN A 390 GLU A 393 
AA6 1 SER A 435 ? ASP A 440 ? SER A 435 ASP A 440 
AA6 2 VAL A 415 ? ASN A 428 ? VAL A 415 ASN A 428 
AA6 3 GLU A 397 ? VAL A 410 ? GLU A 397 VAL A 410 
AA6 4 ALA A 447 ? ASP A 451 ? ALA A 447 ASP A 451 
AA7 1 MET A 503 ? ILE A 504 ? MET A 503 ILE A 504 
AA7 2 THR A 552 ? PRO A 553 ? THR A 552 PRO A 553 
AA8 1 LYS A 519 ? LEU A 520 ? LYS A 519 LEU A 520 
AA8 2 GLY A 544 ? TYR A 550 ? GLY A 544 TYR A 550 
AA8 3 ASN A 619 ? THR A 625 ? ASN A 619 THR A 625 
AA8 4 ILE A 573 ? LEU A 579 ? ILE A 573 LEU A 579 
AA8 5 ALA A 582 ? PHE A 589 ? ALA A 582 PHE A 589 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 296 ? N LYS A 296 O ILE A 509 ? O ILE A 509 
AA1 2 3 N LEU A 512 ? N LEU A 512 O ILE A 638 ? O ILE A 638 
AA1 3 4 O GLU A 639 ? O GLU A 639 N ARG A 564 ? N ARG A 564 
AA1 4 5 N ILE A 565 ? N ILE A 565 O ALA A 607 ? O ALA A 607 
AA2 1 2 N SER A 525 ? N SER A 525 O GLN A 539 ? O GLN A 539 
AA2 2 3 N ILE A 538 ? N ILE A 538 O ILE A 635 ? O ILE A 635 
AA2 3 4 O GLU A 639 ? O GLU A 639 N ARG A 564 ? N ARG A 564 
AA2 4 5 N TYR A 561 ? N TYR A 561 O PHE A 613 ? O PHE A 613 
AA3 1 2 N VAL A 303 ? N VAL A 303 O TRP A 493 ? O TRP A 493 
AA3 2 3 O THR A 492 ? O THR A 492 N ASN A 474 ? N ASN A 474 
AA4 1 2 O ILE A 376 ? O ILE A 376 N THR A 366 ? N THR A 366 
AA4 2 3 N ASN A 362 ? N ASN A 362 O TYR A 381 ? O TYR A 381 
AA5 1 2 O ILE A 376 ? O ILE A 376 N THR A 366 ? N THR A 366 
AA5 2 3 O PHE A 356 ? O PHE A 356 N GLN A 347 ? N GLN A 347 
AA5 3 4 N PHE A 342 ? N PHE A 342 O GLN A 390 ? O GLN A 390 
AA6 1 2 O GLN A 437 ? O GLN A 437 N PHE A 424 ? N PHE A 424 
AA6 2 3 O THR A 420 ? O THR A 420 N ASN A 405 ? N ASN A 405 
AA6 3 4 N ALA A 404 ? N ALA A 404 O SER A 449 ? O SER A 449 
AA7 1 2 N ILE A 504 ? N ILE A 504 O THR A 552 ? O THR A 552 
AA8 1 2 N LYS A 519 ? N LYS A 519 O THR A 548 ? O THR A 548 
AA8 2 3 N ALA A 546 ? N ALA A 546 O ILE A 622 ? O ILE A 622 
AA8 3 4 O THR A 625 ? O THR A 625 N THR A 574 ? N THR A 574 
AA8 4 5 N LEU A 577 ? N LEU A 577 O ASN A 585 ? O ASN A 585 
# 
_pdbx_entry_details.entry_id                   8YQH 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OG1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   THR 
_pdbx_validate_close_contact.auth_seq_id_1    62 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   OE2 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   GLU 
_pdbx_validate_close_contact.auth_seq_id_2    271 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.06 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OH 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    TYR 
_pdbx_validate_symm_contact.auth_seq_id_1     317 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OG 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    SER 
_pdbx_validate_symm_contact.auth_seq_id_2     558 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   8_445 
_pdbx_validate_symm_contact.dist              2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 THR A 62  ? ? 58.52   101.05  
2  1 VAL A 79  ? ? -95.09  41.28   
3  1 SER A 102 ? ? -153.11 -150.76 
4  1 LYS A 128 ? ? -55.40  -9.46   
5  1 ASN A 138 ? ? -60.46  -71.55  
6  1 ASN A 139 ? ? -20.05  -62.36  
7  1 ASN A 153 ? ? -36.29  114.80  
8  1 LYS A 253 ? ? -66.78  1.26    
9  1 VAL A 276 ? ? -137.13 -69.00  
10 1 ASP A 306 ? ? -46.08  150.93  
11 1 PRO A 331 ? ? -38.55  116.99  
12 1 ASN A 353 ? ? -139.87 -57.57  
13 1 PRO A 379 ? ? -62.38  -176.99 
14 1 THR A 431 ? ? -153.78 34.27   
15 1 ASP A 432 ? ? 25.53   65.20   
16 1 LYS A 442 ? ? 81.20   15.15   
17 1 ARG A 443 ? ? -171.25 100.58  
18 1 ASN A 444 ? ? 68.91   63.25   
19 1 GLN A 455 ? ? -130.68 -35.84  
20 1 LEU A 456 ? ? -119.36 73.00   
21 1 PRO A 457 ? ? -57.86  178.54  
22 1 TYR A 475 ? ? -171.87 143.62  
23 1 SER A 484 ? ? -20.66  74.44   
24 1 LYS A 519 ? ? -172.51 133.21  
25 1 ARG A 531 ? ? 91.75   -12.89  
26 1 SER A 558 ? ? -49.26  84.65   
27 1 ASP A 636 ? ? -104.53 -60.43  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1  ? A MET 1  
2  1 Y 1 A ASN 2  ? A ASN 2  
3  1 Y 1 A PRO 3  ? A PRO 3  
4  1 Y 1 A ASN 4  ? A ASN 4  
5  1 Y 1 A ASN 5  ? A ASN 5  
6  1 Y 1 A ARG 6  ? A ARG 6  
7  1 Y 1 A SER 7  ? A SER 7  
8  1 Y 1 A GLU 8  ? A GLU 8  
9  1 Y 1 A HIS 9  ? A HIS 9  
10 1 Y 1 A ASP 10 ? A ASP 10 
11 1 Y 1 A THR 11 ? A THR 11 
12 1 Y 1 A ILE 12 ? A ILE 12 
13 1 Y 1 A LYS 13 ? A LYS 13 
14 1 Y 1 A THR 14 ? A THR 14 
15 1 Y 1 A THR 15 ? A THR 15 
16 1 Y 1 A GLU 16 ? A GLU 16 
17 1 Y 1 A ASN 17 ? A ASN 17 
18 1 Y 1 A ASN 18 ? A ASN 18 
19 1 Y 1 A GLU 19 ? A GLU 19 
20 1 Y 1 A VAL 20 ? A VAL 20 
21 1 Y 1 A PRO 21 ? A PRO 21 
22 1 Y 1 A THR 22 ? A THR 22 
23 1 Y 1 A ASN 23 ? A ASN 23 
24 1 Y 1 A HIS 24 ? A HIS 24 
25 1 Y 1 A VAL 25 ? A VAL 25 
26 1 Y 1 A GLN 26 ? A GLN 26 
27 1 Y 1 A TYR 27 ? A TYR 27 
28 1 Y 1 A PRO 28 ? A PRO 28 
29 1 Y 1 A LEU 29 ? A LEU 29 
30 1 Y 1 A ALA 30 ? A ALA 30 
31 1 Y 1 A GLU 31 ? A GLU 31 
32 1 Y 1 A THR 32 ? A THR 32 
33 1 Y 1 A PRO 33 ? A PRO 33 
34 1 Y 1 A ASN 34 ? A ASN 34 
35 1 Y 1 A PRO 35 ? A PRO 35 
36 1 Y 1 A THR 36 ? A THR 36 
37 1 Y 1 A LEU 37 ? A LEU 37 
38 1 Y 1 A GLU 38 ? A GLU 38 
39 1 Y 1 A ASP 39 ? A ASP 39 
40 1 Y 1 A LEU 40 ? A LEU 40 
41 1 Y 1 A ASN 41 ? A ASN 41 
42 1 Y 1 A TYR 42 ? A TYR 42 
43 1 Y 1 A LYS 43 ? A LYS 43 
44 1 Y 1 A GLU 44 ? A GLU 44 
45 1 Y 1 A PHE 45 ? A PHE 45 
46 1 Y 1 A LEU 46 ? A LEU 46 
47 1 Y 1 A ARG 47 ? A ARG 47 
48 1 Y 1 A MET 48 ? A MET 48 
49 1 Y 1 A THR 49 ? A THR 49 
50 1 Y 1 A ALA 50 ? A ALA 50 
51 1 Y 1 A ASP 51 ? A ASP 51 
52 1 Y 1 A ASN 52 ? A ASN 52 
53 1 Y 1 A ASN 53 ? A ASN 53 
54 1 Y 1 A THR 54 ? A THR 54 
55 1 Y 1 A GLU 55 ? A GLU 55 
56 1 Y 1 A ALA 56 ? A ALA 56 
57 1 Y 1 A LEU 57 ? A LEU 57 
58 1 Y 1 A ASP 58 ? A ASP 58 
59 1 Y 1 A SER 59 ? A SER 59 
60 1 Y 1 A SER 60 ? A SER 60 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Other government' 'Hong Kong' 'CUHK Idea Booster Fund IDBF23SCI18'             1 
'Other government' 'Hong Kong' 'Hong Kong Research Grants Council GRF 14323216' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1DLC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YQH 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008632 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007498 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009452 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . THR A 1 61  ? -29.080 -33.285 -23.016 1.00 98.55  ? 61  THR A N   1 
ATOM   2    C CA  . THR A 1 61  ? -29.542 -31.931 -23.336 1.00 112.14 ? 61  THR A CA  1 
ATOM   3    C C   . THR A 1 61  ? -28.654 -30.820 -22.696 1.00 114.04 ? 61  THR A C   1 
ATOM   4    O O   . THR A 1 61  ? -28.518 -30.715 -21.462 1.00 105.87 ? 61  THR A O   1 
ATOM   5    C CB  . THR A 1 61  ? -31.051 -31.760 -22.942 1.00 100.40 ? 61  THR A CB  1 
ATOM   6    O OG1 . THR A 1 61  ? -31.549 -30.504 -23.424 1.00 99.44  ? 61  THR A OG1 1 
ATOM   7    C CG2 . THR A 1 61  ? -31.288 -31.899 -21.430 1.00 85.81  ? 61  THR A CG2 1 
ATOM   8    N N   . THR A 1 62  ? -28.042 -30.012 -23.582 1.00 112.61 ? 62  THR A N   1 
ATOM   9    C CA  . THR A 1 62  ? -27.059 -28.961 -23.283 1.00 107.66 ? 62  THR A CA  1 
ATOM   10   C C   . THR A 1 62  ? -25.801 -29.474 -22.553 1.00 102.81 ? 62  THR A C   1 
ATOM   11   O O   . THR A 1 62  ? -25.830 -29.735 -21.339 1.00 97.38  ? 62  THR A O   1 
ATOM   12   C CB  . THR A 1 62  ? -27.723 -27.789 -22.512 1.00 101.31 ? 62  THR A CB  1 
ATOM   13   O OG1 . THR A 1 62  ? -28.274 -28.239 -21.265 1.00 100.19 ? 62  THR A OG1 1 
ATOM   14   C CG2 . THR A 1 62  ? -28.820 -27.100 -23.348 1.00 86.20  ? 62  THR A CG2 1 
ATOM   15   N N   . LYS A 1 63  ? -24.696 -29.654 -23.314 1.00 97.20  ? 63  LYS A N   1 
ATOM   16   C CA  . LYS A 1 63  ? -23.336 -29.809 -22.782 1.00 95.82  ? 63  LYS A CA  1 
ATOM   17   C C   . LYS A 1 63  ? -22.396 -28.740 -23.323 1.00 93.18  ? 63  LYS A C   1 
ATOM   18   O O   . LYS A 1 63  ? -21.186 -28.821 -23.084 1.00 88.67  ? 63  LYS A O   1 
ATOM   19   C CB  . LYS A 1 63  ? -22.692 -31.171 -23.132 1.00 94.77  ? 63  LYS A CB  1 
ATOM   20   C CG  . LYS A 1 63  ? -23.508 -32.449 -22.974 1.00 84.78  ? 63  LYS A CG  1 
ATOM   21   C CD  . LYS A 1 63  ? -24.158 -32.754 -24.328 1.00 86.81  ? 63  LYS A CD  1 
ATOM   22   C CE  . LYS A 1 63  ? -24.804 -34.110 -24.417 1.00 79.52  ? 63  LYS A CE  1 
ATOM   23   N NZ  . LYS A 1 63  ? -25.556 -34.253 -25.693 1.00 77.58  ? 63  LYS A NZ  1 
ATOM   24   N N   . ASP A 1 64  ? -22.908 -27.776 -24.090 1.00 96.91  ? 64  ASP A N   1 
ATOM   25   C CA  . ASP A 1 64  ? -22.059 -26.782 -24.742 1.00 99.81  ? 64  ASP A CA  1 
ATOM   26   C C   . ASP A 1 64  ? -21.760 -25.618 -23.799 1.00 89.10  ? 64  ASP A C   1 
ATOM   27   O O   . ASP A 1 64  ? -20.593 -25.277 -23.571 1.00 87.44  ? 64  ASP A O   1 
ATOM   28   C CB  . ASP A 1 64  ? -22.742 -26.314 -26.042 1.00 101.57 ? 64  ASP A CB  1 
ATOM   29   C CG  . ASP A 1 64  ? -21.855 -25.420 -26.909 1.00 103.14 ? 64  ASP A CG  1 
ATOM   30   O OD1 . ASP A 1 64  ? -20.609 -25.485 -26.787 1.00 106.05 ? 64  ASP A OD1 1 
ATOM   31   O OD2 . ASP A 1 64  ? -22.417 -24.679 -27.749 1.00 101.55 ? 64  ASP A OD2 1 
ATOM   32   N N   . VAL A 1 65  ? -22.805 -25.016 -23.226 1.00 87.07  ? 65  VAL A N   1 
ATOM   33   C CA  . VAL A 1 65  ? -22.627 -23.998 -22.196 1.00 83.19  ? 65  VAL A CA  1 
ATOM   34   C C   . VAL A 1 65  ? -22.390 -24.636 -20.829 1.00 82.66  ? 65  VAL A C   1 
ATOM   35   O O   . VAL A 1 65  ? -21.616 -24.111 -20.017 1.00 81.59  ? 65  VAL A O   1 
ATOM   36   C CB  . VAL A 1 65  ? -23.842 -23.049 -22.173 1.00 84.07  ? 65  VAL A CB  1 
ATOM   37   C CG1 . VAL A 1 65  ? -23.866 -22.201 -23.432 1.00 79.67  ? 65  VAL A CG1 1 
ATOM   38   C CG2 . VAL A 1 65  ? -25.152 -23.832 -22.031 1.00 75.13  ? 65  VAL A CG2 1 
ATOM   39   N N   . ILE A 1 66  ? -23.036 -25.775 -20.558 1.00 86.23  ? 66  ILE A N   1 
ATOM   40   C CA  . ILE A 1 66  ? -22.911 -26.455 -19.274 1.00 78.41  ? 66  ILE A CA  1 
ATOM   41   C C   . ILE A 1 66  ? -21.529 -27.057 -19.075 1.00 78.28  ? 66  ILE A C   1 
ATOM   42   O O   . ILE A 1 66  ? -21.200 -27.461 -17.958 1.00 81.48  ? 66  ILE A O   1 
ATOM   43   C CB  . ILE A 1 66  ? -24.027 -27.514 -19.163 1.00 72.11  ? 66  ILE A CB  1 
ATOM   44   C CG1 . ILE A 1 66  ? -25.359 -26.887 -19.567 1.00 72.76  ? 66  ILE A CG1 1 
ATOM   45   C CG2 . ILE A 1 66  ? -24.156 -28.039 -17.753 1.00 59.46  ? 66  ILE A CG2 1 
ATOM   46   C CD1 . ILE A 1 66  ? -25.773 -25.744 -18.690 1.00 66.43  ? 66  ILE A CD1 1 
ATOM   47   N N   . GLN A 1 67  ? -20.710 -27.127 -20.130 1.00 78.79  ? 67  GLN A N   1 
ATOM   48   C CA  . GLN A 1 67  ? -19.292 -27.481 -20.019 1.00 80.42  ? 67  GLN A CA  1 
ATOM   49   C C   . GLN A 1 67  ? -18.438 -26.243 -19.760 1.00 80.40  ? 67  GLN A C   1 
ATOM   50   O O   . GLN A 1 67  ? -17.653 -26.207 -18.806 1.00 81.38  ? 67  GLN A O   1 
ATOM   51   C CB  . GLN A 1 67  ? -18.825 -28.203 -21.294 1.00 82.87  ? 67  GLN A CB  1 
ATOM   52   C CG  . GLN A 1 67  ? -17.345 -28.626 -21.368 1.00 75.87  ? 67  GLN A CG  1 
ATOM   53   C CD  . GLN A 1 67  ? -16.929 -29.627 -20.307 1.00 82.82  ? 67  GLN A CD  1 
ATOM   54   O OE1 . GLN A 1 67  ? -16.884 -30.840 -20.567 1.00 81.76  ? 67  GLN A OE1 1 
ATOM   55   N NE2 . GLN A 1 67  ? -16.551 -29.124 -19.128 1.00 81.00  ? 67  GLN A NE2 1 
ATOM   56   N N   . LYS A 1 68  ? -18.577 -25.230 -20.618 1.00 77.49  ? 68  LYS A N   1 
ATOM   57   C CA  . LYS A 1 68  ? -17.949 -23.946 -20.365 1.00 75.89  ? 68  LYS A CA  1 
ATOM   58   C C   . LYS A 1 68  ? -18.379 -23.389 -19.012 1.00 78.50  ? 68  LYS A C   1 
ATOM   59   O O   . LYS A 1 68  ? -17.595 -22.702 -18.348 1.00 76.74  ? 68  LYS A O   1 
ATOM   60   C CB  . LYS A 1 68  ? -18.295 -22.995 -21.515 1.00 77.41  ? 68  LYS A CB  1 
ATOM   61   C CG  . LYS A 1 68  ? -17.710 -23.463 -22.844 1.00 76.00  ? 68  LYS A CG  1 
ATOM   62   C CD  . LYS A 1 68  ? -18.158 -22.591 -23.991 1.00 82.06  ? 68  LYS A CD  1 
ATOM   63   C CE  . LYS A 1 68  ? -18.057 -23.317 -25.334 1.00 76.67  ? 68  LYS A CE  1 
ATOM   64   N NZ  . LYS A 1 68  ? -16.677 -23.702 -25.701 1.00 67.55  ? 68  LYS A NZ  1 
ATOM   65   N N   . GLY A 1 69  ? -19.600 -23.720 -18.568 1.00 78.85  ? 69  GLY A N   1 
ATOM   66   C CA  . GLY A 1 69  ? -20.068 -23.293 -17.258 1.00 73.66  ? 69  GLY A CA  1 
ATOM   67   C C   . GLY A 1 69  ? -19.362 -23.955 -16.084 1.00 71.14  ? 69  GLY A C   1 
ATOM   68   O O   . GLY A 1 69  ? -19.270 -23.362 -15.005 1.00 64.65  ? 69  GLY A O   1 
ATOM   69   N N   . ILE A 1 70  ? -18.849 -25.175 -16.265 1.00 68.58  ? 70  ILE A N   1 
ATOM   70   C CA  . ILE A 1 70  ? -18.184 -25.861 -15.160 1.00 73.25  ? 70  ILE A CA  1 
ATOM   71   C C   . ILE A 1 70  ? -16.663 -25.734 -15.272 1.00 78.59  ? 70  ILE A C   1 
ATOM   72   O O   . ILE A 1 70  ? -15.955 -25.772 -14.257 1.00 76.33  ? 70  ILE A O   1 
ATOM   73   C CB  . ILE A 1 70  ? -18.588 -27.343 -15.075 1.00 70.55  ? 70  ILE A CB  1 
ATOM   74   C CG1 . ILE A 1 70  ? -20.101 -27.500 -15.072 1.00 61.28  ? 70  ILE A CG1 1 
ATOM   75   C CG2 . ILE A 1 70  ? -18.080 -27.943 -13.762 1.00 68.09  ? 70  ILE A CG2 1 
ATOM   76   C CD1 . ILE A 1 70  ? -20.535 -28.879 -15.451 1.00 54.01  ? 70  ILE A CD1 1 
ATOM   77   N N   . SER A 1 71  ? -16.135 -25.612 -16.497 1.00 81.61  ? 71  SER A N   1 
ATOM   78   C CA  . SER A 1 71  ? -14.716 -25.281 -16.635 1.00 79.48  ? 71  SER A CA  1 
ATOM   79   C C   . SER A 1 71  ? -14.397 -23.956 -15.954 1.00 79.51  ? 71  SER A C   1 
ATOM   80   O O   . SER A 1 71  ? -13.346 -23.823 -15.319 1.00 79.04  ? 71  SER A O   1 
ATOM   81   C CB  . SER A 1 71  ? -14.289 -25.235 -18.109 1.00 76.33  ? 71  SER A CB  1 
ATOM   82   O OG  . SER A 1 71  ? -14.144 -26.531 -18.675 1.00 78.73  ? 71  SER A OG  1 
ATOM   83   N N   . VAL A 1 72  ? -15.293 -22.966 -16.061 1.00 77.09  ? 72  VAL A N   1 
ATOM   84   C CA  . VAL A 1 72  ? -14.963 -21.636 -15.558 1.00 74.01  ? 72  VAL A CA  1 
ATOM   85   C C   . VAL A 1 72  ? -14.965 -21.629 -14.037 1.00 75.66  ? 72  VAL A C   1 
ATOM   86   O O   . VAL A 1 72  ? -14.080 -21.037 -13.409 1.00 73.05  ? 72  VAL A O   1 
ATOM   87   C CB  . VAL A 1 72  ? -15.913 -20.568 -16.136 1.00 74.49  ? 72  VAL A CB  1 
ATOM   88   C CG1 . VAL A 1 72  ? -15.682 -19.217 -15.463 1.00 73.37  ? 72  VAL A CG1 1 
ATOM   89   C CG2 . VAL A 1 72  ? -15.690 -20.408 -17.604 1.00 76.12  ? 72  VAL A CG2 1 
ATOM   90   N N   . VAL A 1 73  ? -15.944 -22.297 -13.414 1.00 78.14  ? 73  VAL A N   1 
ATOM   91   C CA  . VAL A 1 73  ? -15.955 -22.375 -11.951 1.00 73.32  ? 73  VAL A CA  1 
ATOM   92   C C   . VAL A 1 73  ? -14.850 -23.316 -11.454 1.00 76.47  ? 73  VAL A C   1 
ATOM   93   O O   . VAL A 1 73  ? -14.254 -23.083 -10.393 1.00 73.28  ? 73  VAL A O   1 
ATOM   94   C CB  . VAL A 1 73  ? -17.349 -22.794 -11.437 1.00 56.71  ? 73  VAL A CB  1 
ATOM   95   C CG1 . VAL A 1 73  ? -17.316 -23.024 -9.954  1.00 51.61  ? 73  VAL A CG1 1 
ATOM   96   C CG2 . VAL A 1 73  ? -18.369 -21.733 -11.766 1.00 51.29  ? 73  VAL A CG2 1 
ATOM   97   N N   . GLY A 1 74  ? -14.537 -24.368 -12.220 1.00 76.54  ? 74  GLY A N   1 
ATOM   98   C CA  . GLY A 1 74  ? -13.431 -25.240 -11.863 1.00 69.65  ? 74  GLY A CA  1 
ATOM   99   C C   . GLY A 1 74  ? -12.070 -24.602 -12.066 1.00 73.61  ? 74  GLY A C   1 
ATOM   100  O O   . GLY A 1 74  ? -11.128 -24.900 -11.326 1.00 79.72  ? 74  GLY A O   1 
ATOM   101  N N   . ASP A 1 75  ? -11.938 -23.728 -13.070 1.00 75.93  ? 75  ASP A N   1 
ATOM   102  C CA  . ASP A 1 75  ? -10.683 -23.005 -13.290 1.00 82.60  ? 75  ASP A CA  1 
ATOM   103  C C   . ASP A 1 75  ? -10.512 -21.834 -12.313 1.00 80.47  ? 75  ASP A C   1 
ATOM   104  O O   . ASP A 1 75  ? -9.378  -21.538 -11.897 1.00 73.96  ? 75  ASP A O   1 
ATOM   105  C CB  . ASP A 1 75  ? -10.601 -22.475 -14.735 1.00 83.83  ? 75  ASP A CB  1 
ATOM   106  C CG  . ASP A 1 75  ? -10.177 -23.534 -15.757 1.00 78.55  ? 75  ASP A CG  1 
ATOM   107  O OD1 . ASP A 1 75  ? -10.593 -24.712 -15.651 1.00 80.78  ? 75  ASP A OD1 1 
ATOM   108  O OD2 . ASP A 1 75  ? -9.431  -23.156 -16.689 1.00 78.88  ? 75  ASP A OD2 1 
ATOM   109  N N   . LEU A 1 76  ? -11.620 -21.162 -11.946 1.00 76.70  ? 76  LEU A N   1 
ATOM   110  C CA  . LEU A 1 76  ? -11.597 -19.968 -11.102 1.00 73.27  ? 76  LEU A CA  1 
ATOM   111  C C   . LEU A 1 76  ? -11.364 -20.258 -9.627  1.00 73.45  ? 76  LEU A C   1 
ATOM   112  O O   . LEU A 1 76  ? -11.036 -19.317 -8.893  1.00 71.75  ? 76  LEU A O   1 
ATOM   113  C CB  . LEU A 1 76  ? -12.902 -19.176 -11.232 1.00 67.03  ? 76  LEU A CB  1 
ATOM   114  C CG  . LEU A 1 76  ? -12.945 -18.089 -12.300 1.00 63.13  ? 76  LEU A CG  1 
ATOM   115  C CD1 . LEU A 1 76  ? -14.363 -17.602 -12.529 1.00 56.77  ? 76  LEU A CD1 1 
ATOM   116  C CD2 . LEU A 1 76  ? -12.048 -16.941 -11.896 1.00 59.08  ? 76  LEU A CD2 1 
ATOM   117  N N   . LEU A 1 77  ? -11.522 -21.511 -9.175  1.00 68.13  ? 77  LEU A N   1 
ATOM   118  C CA  . LEU A 1 77  ? -11.308 -21.850 -7.770  1.00 70.39  ? 77  LEU A CA  1 
ATOM   119  C C   . LEU A 1 77  ? -9.830  -21.952 -7.395  1.00 71.99  ? 77  LEU A C   1 
ATOM   120  O O   . LEU A 1 77  ? -9.534  -22.183 -6.214  1.00 73.80  ? 77  LEU A O   1 
ATOM   121  C CB  . LEU A 1 77  ? -12.015 -23.170 -7.411  1.00 74.16  ? 77  LEU A CB  1 
ATOM   122  C CG  . LEU A 1 77  ? -13.527 -23.220 -7.077  1.00 67.41  ? 77  LEU A CG  1 
ATOM   123  C CD1 . LEU A 1 77  ? -14.132 -24.576 -7.461  1.00 54.50  ? 77  LEU A CD1 1 
ATOM   124  C CD2 . LEU A 1 77  ? -13.853 -22.897 -5.620  1.00 57.12  ? 77  LEU A CD2 1 
ATOM   125  N N   . GLY A 1 78  ? -8.906  -21.791 -8.354  1.00 63.82  ? 78  GLY A N   1 
ATOM   126  C CA  . GLY A 1 78  ? -7.482  -21.758 -8.061  1.00 62.59  ? 78  GLY A CA  1 
ATOM   127  C C   . GLY A 1 78  ? -6.980  -20.344 -7.832  1.00 76.56  ? 78  GLY A C   1 
ATOM   128  O O   . GLY A 1 78  ? -6.284  -20.051 -6.848  1.00 83.87  ? 78  GLY A O   1 
ATOM   129  N N   . VAL A 1 79  ? -7.367  -19.449 -8.740  1.00 76.27  ? 79  VAL A N   1 
ATOM   130  C CA  . VAL A 1 79  ? -6.932  -18.055 -8.763  1.00 71.57  ? 79  VAL A CA  1 
ATOM   131  C C   . VAL A 1 79  ? -7.961  -17.188 -8.047  1.00 76.68  ? 79  VAL A C   1 
ATOM   132  O O   . VAL A 1 79  ? -8.295  -16.083 -8.497  1.00 76.92  ? 79  VAL A O   1 
ATOM   133  C CB  . VAL A 1 79  ? -6.734  -17.587 -10.213 1.00 68.05  ? 79  VAL A CB  1 
ATOM   134  C CG1 . VAL A 1 79  ? -5.535  -18.284 -10.805 1.00 76.66  ? 79  VAL A CG1 1 
ATOM   135  C CG2 . VAL A 1 79  ? -7.990  -17.887 -11.034 1.00 65.20  ? 79  VAL A CG2 1 
ATOM   136  N N   . VAL A 1 80  ? -8.474  -17.686 -6.929  1.00 75.31  ? 80  VAL A N   1 
ATOM   137  C CA  . VAL A 1 80  ? -9.591  -17.067 -6.230  1.00 60.65  ? 80  VAL A CA  1 
ATOM   138  C C   . VAL A 1 80  ? -9.044  -16.586 -4.885  1.00 56.45  ? 80  VAL A C   1 
ATOM   139  O O   . VAL A 1 80  ? -8.515  -17.382 -4.092  1.00 56.49  ? 80  VAL A O   1 
ATOM   140  C CB  . VAL A 1 80  ? -10.782 -18.049 -6.117  1.00 58.37  ? 80  VAL A CB  1 
ATOM   141  C CG1 . VAL A 1 80  ? -10.627 -19.124 -5.033  1.00 55.84  ? 80  VAL A CG1 1 
ATOM   142  C CG2 . VAL A 1 80  ? -12.105 -17.343 -6.059  1.00 52.15  ? 80  VAL A CG2 1 
ATOM   143  N N   . GLY A 1 81  ? -9.096  -15.270 -4.666  1.00 49.75  ? 81  GLY A N   1 
ATOM   144  C CA  . GLY A 1 81  ? -8.346  -14.636 -3.594  1.00 42.50  ? 81  GLY A CA  1 
ATOM   145  C C   . GLY A 1 81  ? -7.212  -13.859 -4.229  1.00 55.67  ? 81  GLY A C   1 
ATOM   146  O O   . GLY A 1 81  ? -7.407  -13.291 -5.310  1.00 62.36  ? 81  GLY A O   1 
ATOM   147  N N   . PHE A 1 82  ? -6.021  -13.834 -3.600  1.00 56.08  ? 82  PHE A N   1 
ATOM   148  C CA  . PHE A 1 82  ? -4.815  -13.259 -4.205  1.00 55.59  ? 82  PHE A CA  1 
ATOM   149  C C   . PHE A 1 82  ? -4.058  -14.362 -4.955  1.00 62.62  ? 82  PHE A C   1 
ATOM   150  O O   . PHE A 1 82  ? -3.344  -15.157 -4.325  1.00 62.03  ? 82  PHE A O   1 
ATOM   151  C CB  . PHE A 1 82  ? -3.925  -12.628 -3.123  1.00 51.54  ? 82  PHE A CB  1 
ATOM   152  C CG  . PHE A 1 82  ? -2.982  -11.544 -3.627  1.00 58.75  ? 82  PHE A CG  1 
ATOM   153  C CD1 . PHE A 1 82  ? -2.034  -11.811 -4.610  1.00 60.88  ? 82  PHE A CD1 1 
ATOM   154  C CD2 . PHE A 1 82  ? -3.017  -10.271 -3.070  1.00 56.15  ? 82  PHE A CD2 1 
ATOM   155  C CE1 . PHE A 1 82  ? -1.167  -10.835 -5.054  1.00 45.82  ? 82  PHE A CE1 1 
ATOM   156  C CE2 . PHE A 1 82  ? -2.155  -9.293  -3.510  1.00 62.49  ? 82  PHE A CE2 1 
ATOM   157  C CZ  . PHE A 1 82  ? -1.227  -9.584  -4.514  1.00 53.61  ? 82  PHE A CZ  1 
ATOM   158  N N   . PRO A 1 83  ? -4.183  -14.460 -6.283  1.00 69.21  ? 83  PRO A N   1 
ATOM   159  C CA  . PRO A 1 83  ? -3.483  -15.541 -7.005  1.00 79.04  ? 83  PRO A CA  1 
ATOM   160  C C   . PRO A 1 83  ? -1.989  -15.262 -7.127  1.00 83.34  ? 83  PRO A C   1 
ATOM   161  O O   . PRO A 1 83  ? -1.582  -14.159 -7.512  1.00 78.19  ? 83  PRO A O   1 
ATOM   162  C CB  . PRO A 1 83  ? -4.167  -15.552 -8.379  1.00 79.61  ? 83  PRO A CB  1 
ATOM   163  C CG  . PRO A 1 83  ? -4.689  -14.146 -8.546  1.00 72.55  ? 83  PRO A CG  1 
ATOM   164  C CD  . PRO A 1 83  ? -5.081  -13.689 -7.169  1.00 63.37  ? 83  PRO A CD  1 
ATOM   165  N N   . PHE A 1 84  ? -1.168  -16.267 -6.782  1.00 88.40  ? 84  PHE A N   1 
ATOM   166  C CA  . PHE A 1 84  ? 0.263   -16.148 -7.048  1.00 93.00  ? 84  PHE A CA  1 
ATOM   167  C C   . PHE A 1 84  ? 0.398   -15.837 -8.538  1.00 98.23  ? 84  PHE A C   1 
ATOM   168  O O   . PHE A 1 84  ? 0.045   -16.662 -9.389  1.00 100.86 ? 84  PHE A O   1 
ATOM   169  C CB  . PHE A 1 84  ? 1.045   -17.399 -6.568  1.00 87.91  ? 84  PHE A CB  1 
ATOM   170  C CG  . PHE A 1 84  ? 1.317   -18.451 -7.637  1.00 104.57 ? 84  PHE A CG  1 
ATOM   171  C CD1 . PHE A 1 84  ? 2.433   -18.349 -8.478  1.00 103.83 ? 84  PHE A CD1 1 
ATOM   172  C CD2 . PHE A 1 84  ? 0.504   -19.586 -7.747  1.00 99.00  ? 84  PHE A CD2 1 
ATOM   173  C CE1 . PHE A 1 84  ? 2.690   -19.322 -9.453  1.00 97.35  ? 84  PHE A CE1 1 
ATOM   174  C CE2 . PHE A 1 84  ? 0.769   -20.569 -8.711  1.00 94.96  ? 84  PHE A CE2 1 
ATOM   175  C CZ  . PHE A 1 84  ? 1.864   -20.433 -9.561  1.00 91.39  ? 84  PHE A CZ  1 
ATOM   176  N N   . GLY A 1 85  ? 0.819   -14.603 -8.848  1.00 95.42  ? 85  GLY A N   1 
ATOM   177  C CA  . GLY A 1 85  ? 0.754   -14.014 -10.181 1.00 90.95  ? 85  GLY A CA  1 
ATOM   178  C C   . GLY A 1 85  ? 0.960   -14.923 -11.384 1.00 93.49  ? 85  GLY A C   1 
ATOM   179  O O   . GLY A 1 85  ? 0.422   -14.654 -12.465 1.00 82.41  ? 85  GLY A O   1 
ATOM   180  N N   . GLY A 1 86  ? 1.743   -15.998 -11.206 1.00 105.51 ? 86  GLY A N   1 
ATOM   181  C CA  . GLY A 1 86  ? 1.962   -16.956 -12.280 1.00 99.35  ? 86  GLY A CA  1 
ATOM   182  C C   . GLY A 1 86  ? 0.726   -17.758 -12.650 1.00 95.79  ? 86  GLY A C   1 
ATOM   183  O O   . GLY A 1 86  ? 0.554   -18.130 -13.815 1.00 87.96  ? 86  GLY A O   1 
ATOM   184  N N   . ALA A 1 87  ? -0.150  -18.037 -11.675 1.00 90.93  ? 87  ALA A N   1 
ATOM   185  C CA  . ALA A 1 87  ? -1.396  -18.745 -11.950 1.00 84.62  ? 87  ALA A CA  1 
ATOM   186  C C   . ALA A 1 87  ? -2.488  -17.846 -12.531 1.00 83.71  ? 87  ALA A C   1 
ATOM   187  O O   . ALA A 1 87  ? -3.453  -18.370 -13.103 1.00 80.59  ? 87  ALA A O   1 
ATOM   188  C CB  . ALA A 1 87  ? -1.912  -19.414 -10.673 1.00 89.23  ? 87  ALA A CB  1 
ATOM   189  N N   . LEU A 1 88  ? -2.362  -16.514 -12.399 1.00 84.15  ? 88  LEU A N   1 
ATOM   190  C CA  . LEU A 1 88  ? -3.380  -15.582 -12.891 1.00 78.08  ? 88  LEU A CA  1 
ATOM   191  C C   . LEU A 1 88  ? -3.345  -15.446 -14.413 1.00 73.57  ? 88  LEU A C   1 
ATOM   192  O O   . LEU A 1 88  ? -4.337  -15.018 -15.008 1.00 72.09  ? 88  LEU A O   1 
ATOM   193  C CB  . LEU A 1 88  ? -3.210  -14.205 -12.197 1.00 79.23  ? 88  LEU A CB  1 
ATOM   194  C CG  . LEU A 1 88  ? -4.304  -13.111 -12.006 1.00 57.48  ? 88  LEU A CG  1 
ATOM   195  C CD1 . LEU A 1 88  ? -3.815  -11.989 -11.132 1.00 50.33  ? 88  LEU A CD1 1 
ATOM   196  C CD2 . LEU A 1 88  ? -4.754  -12.487 -13.283 1.00 58.12  ? 88  LEU A CD2 1 
ATOM   197  N N   . VAL A 1 89  ? -2.237  -15.815 -15.058 1.00 79.78  ? 89  VAL A N   1 
ATOM   198  C CA  . VAL A 1 89  ? -2.147  -15.821 -16.515 1.00 74.60  ? 89  VAL A CA  1 
ATOM   199  C C   . VAL A 1 89  ? -2.306  -17.258 -17.008 1.00 78.02  ? 89  VAL A C   1 
ATOM   200  O O   . VAL A 1 89  ? -2.836  -17.488 -18.102 1.00 80.36  ? 89  VAL A O   1 
ATOM   201  C CB  . VAL A 1 89  ? -0.828  -15.188 -17.008 1.00 72.18  ? 89  VAL A CB  1 
ATOM   202  C CG1 . VAL A 1 89  ? -0.888  -14.942 -18.494 1.00 68.57  ? 89  VAL A CG1 1 
ATOM   203  C CG2 . VAL A 1 89  ? -0.544  -13.871 -16.275 1.00 71.81  ? 89  VAL A CG2 1 
ATOM   204  N N   . SER A 1 90  ? -1.857  -18.236 -16.201 1.00 86.07  ? 90  SER A N   1 
ATOM   205  C CA  . SER A 1 90  ? -2.217  -19.645 -16.421 1.00 87.84  ? 90  SER A CA  1 
ATOM   206  C C   . SER A 1 90  ? -3.723  -19.869 -16.364 1.00 87.37  ? 90  SER A C   1 
ATOM   207  O O   . SER A 1 90  ? -4.211  -20.880 -16.887 1.00 91.60  ? 90  SER A O   1 
ATOM   208  C CB  . SER A 1 90  ? -1.552  -20.573 -15.387 1.00 86.39  ? 90  SER A CB  1 
ATOM   209  O OG  . SER A 1 90  ? -0.156  -20.700 -15.580 1.00 86.76  ? 90  SER A OG  1 
ATOM   210  N N   . PHE A 1 91  ? -4.457  -18.971 -15.703 1.00 84.34  ? 91  PHE A N   1 
ATOM   211  C CA  . PHE A 1 91  ? -5.911  -18.977 -15.761 1.00 79.30  ? 91  PHE A CA  1 
ATOM   212  C C   . PHE A 1 91  ? -6.406  -18.292 -17.031 1.00 79.64  ? 91  PHE A C   1 
ATOM   213  O O   . PHE A 1 91  ? -7.031  -18.924 -17.891 1.00 81.06  ? 91  PHE A O   1 
ATOM   214  C CB  . PHE A 1 91  ? -6.482  -18.269 -14.534 1.00 75.75  ? 91  PHE A CB  1 
ATOM   215  C CG  . PHE A 1 91  ? -7.954  -18.023 -14.626 1.00 77.70  ? 91  PHE A CG  1 
ATOM   216  C CD1 . PHE A 1 91  ? -8.857  -19.058 -14.466 1.00 79.48  ? 91  PHE A CD1 1 
ATOM   217  C CD2 . PHE A 1 91  ? -8.436  -16.765 -14.952 1.00 75.17  ? 91  PHE A CD2 1 
ATOM   218  C CE1 . PHE A 1 91  ? -10.214 -18.831 -14.575 1.00 75.23  ? 91  PHE A CE1 1 
ATOM   219  C CE2 . PHE A 1 91  ? -9.798  -16.533 -15.065 1.00 73.41  ? 91  PHE A CE2 1 
ATOM   220  C CZ  . PHE A 1 91  ? -10.682 -17.565 -14.883 1.00 75.13  ? 91  PHE A CZ  1 
ATOM   221  N N   . TYR A 1 92  ? -6.078  -16.998 -17.172 1.00 80.87  ? 92  TYR A N   1 
ATOM   222  C CA  . TYR A 1 92  ? -6.718  -16.095 -18.135 1.00 83.02  ? 92  TYR A CA  1 
ATOM   223  C C   . TYR A 1 92  ? -6.638  -16.609 -19.575 1.00 89.53  ? 92  TYR A C   1 
ATOM   224  O O   . TYR A 1 92  ? -7.493  -16.253 -20.403 1.00 89.29  ? 92  TYR A O   1 
ATOM   225  C CB  . TYR A 1 92  ? -6.068  -14.703 -18.054 1.00 79.63  ? 92  TYR A CB  1 
ATOM   226  C CG  . TYR A 1 92  ? -6.818  -13.543 -17.357 1.00 75.43  ? 92  TYR A CG  1 
ATOM   227  C CD1 . TYR A 1 92  ? -8.090  -13.119 -17.777 1.00 65.78  ? 92  TYR A CD1 1 
ATOM   228  C CD2 . TYR A 1 92  ? -6.191  -12.811 -16.325 1.00 65.15  ? 92  TYR A CD2 1 
ATOM   229  C CE1 . TYR A 1 92  ? -8.729  -12.016 -17.151 1.00 61.41  ? 92  TYR A CE1 1 
ATOM   230  C CE2 . TYR A 1 92  ? -6.818  -11.726 -15.701 1.00 52.00  ? 92  TYR A CE2 1 
ATOM   231  C CZ  . TYR A 1 92  ? -8.072  -11.335 -16.117 1.00 56.66  ? 92  TYR A CZ  1 
ATOM   232  O OH  . TYR A 1 92  ? -8.651  -10.260 -15.488 1.00 54.47  ? 92  TYR A OH  1 
ATOM   233  N N   . THR A 1 93  ? -5.616  -17.419 -19.910 1.00 91.57  ? 93  THR A N   1 
ATOM   234  C CA  . THR A 1 93  ? -5.559  -18.002 -21.254 1.00 92.51  ? 93  THR A CA  1 
ATOM   235  C C   . THR A 1 93  ? -6.441  -19.244 -21.389 1.00 88.27  ? 93  THR A C   1 
ATOM   236  O O   . THR A 1 93  ? -6.743  -19.642 -22.521 1.00 89.90  ? 93  THR A O   1 
ATOM   237  C CB  . THR A 1 93  ? -4.112  -18.333 -21.676 1.00 80.57  ? 93  THR A CB  1 
ATOM   238  O OG1 . THR A 1 93  ? -3.563  -19.342 -20.824 1.00 80.95  ? 93  THR A OG1 1 
ATOM   239  C CG2 . THR A 1 93  ? -3.220  -17.081 -21.620 1.00 75.97  ? 93  THR A CG2 1 
ATOM   240  N N   . ASN A 1 94  ? -6.870  -19.860 -20.273 1.00 82.21  ? 94  ASN A N   1 
ATOM   241  C CA  . ASN A 1 94  ? -7.970  -20.818 -20.368 1.00 84.74  ? 94  ASN A CA  1 
ATOM   242  C C   . ASN A 1 94  ? -9.305  -20.097 -20.546 1.00 84.54  ? 94  ASN A C   1 
ATOM   243  O O   . ASN A 1 94  ? -10.152 -20.545 -21.327 1.00 83.45  ? 94  ASN A O   1 
ATOM   244  C CB  . ASN A 1 94  ? -8.026  -21.742 -19.137 1.00 83.51  ? 94  ASN A CB  1 
ATOM   245  C CG  . ASN A 1 94  ? -6.787  -22.636 -18.991 1.00 83.30  ? 94  ASN A CG  1 
ATOM   246  O OD1 . ASN A 1 94  ? -5.694  -22.287 -19.429 1.00 81.51  ? 94  ASN A OD1 1 
ATOM   247  N ND2 . ASN A 1 94  ? -6.977  -23.819 -18.410 1.00 77.23  ? 94  ASN A ND2 1 
ATOM   248  N N   . PHE A 1 95  ? -9.494  -18.970 -19.846 1.00 84.15  ? 95  PHE A N   1 
ATOM   249  C CA  . PHE A 1 95  ? -10.755 -18.230 -19.858 1.00 82.65  ? 95  PHE A CA  1 
ATOM   250  C C   . PHE A 1 95  ? -10.996 -17.512 -21.185 1.00 90.75  ? 95  PHE A C   1 
ATOM   251  O O   . PHE A 1 95  ? -12.156 -17.267 -21.540 1.00 88.79  ? 95  PHE A O   1 
ATOM   252  C CB  . PHE A 1 95  ? -10.762 -17.252 -18.671 1.00 78.60  ? 95  PHE A CB  1 
ATOM   253  C CG  . PHE A 1 95  ? -12.110 -16.601 -18.377 1.00 83.05  ? 95  PHE A CG  1 
ATOM   254  C CD1 . PHE A 1 95  ? -13.281 -17.341 -18.357 1.00 84.52  ? 95  PHE A CD1 1 
ATOM   255  C CD2 . PHE A 1 95  ? -12.179 -15.257 -18.027 1.00 72.43  ? 95  PHE A CD2 1 
ATOM   256  C CE1 . PHE A 1 95  ? -14.499 -16.731 -18.056 1.00 79.11  ? 95  PHE A CE1 1 
ATOM   257  C CE2 . PHE A 1 95  ? -13.381 -14.658 -17.725 1.00 62.10  ? 95  PHE A CE2 1 
ATOM   258  C CZ  . PHE A 1 95  ? -14.542 -15.391 -17.740 1.00 65.19  ? 95  PHE A CZ  1 
ATOM   259  N N   . LEU A 1 96  ? -9.930  -17.188 -21.929 1.00 91.09  ? 96  LEU A N   1 
ATOM   260  C CA  . LEU A 1 96  ? -10.071 -16.654 -23.281 1.00 91.62  ? 96  LEU A CA  1 
ATOM   261  C C   . LEU A 1 96  ? -10.487 -17.702 -24.307 1.00 94.10  ? 96  LEU A C   1 
ATOM   262  O O   . LEU A 1 96  ? -11.048 -17.338 -25.345 1.00 97.66  ? 96  LEU A O   1 
ATOM   263  C CB  . LEU A 1 96  ? -8.768  -15.995 -23.741 1.00 93.86  ? 96  LEU A CB  1 
ATOM   264  C CG  . LEU A 1 96  ? -8.733  -14.472 -23.669 1.00 88.09  ? 96  LEU A CG  1 
ATOM   265  C CD1 . LEU A 1 96  ? -9.328  -14.005 -22.349 1.00 82.41  ? 96  LEU A CD1 1 
ATOM   266  C CD2 . LEU A 1 96  ? -7.302  -13.963 -23.858 1.00 81.50  ? 96  LEU A CD2 1 
ATOM   267  N N   . ASN A 1 97  ? -10.212 -18.983 -24.067 1.00 93.22  ? 97  ASN A N   1 
ATOM   268  C CA  . ASN A 1 97  ? -10.705 -20.006 -24.983 1.00 97.53  ? 97  ASN A CA  1 
ATOM   269  C C   . ASN A 1 97  ? -12.047 -20.586 -24.541 1.00 100.37 ? 97  ASN A C   1 
ATOM   270  O O   . ASN A 1 97  ? -12.868 -20.945 -25.398 1.00 102.27 ? 97  ASN A O   1 
ATOM   271  C CB  . ASN A 1 97  ? -9.672  -21.132 -25.149 1.00 100.34 ? 97  ASN A CB  1 
ATOM   272  C CG  . ASN A 1 97  ? -8.457  -20.705 -25.979 1.00 103.58 ? 97  ASN A CG  1 
ATOM   273  O OD1 . ASN A 1 97  ? -7.358  -20.523 -25.447 1.00 99.31  ? 97  ASN A OD1 1 
ATOM   274  N ND2 . ASN A 1 97  ? -8.656  -20.543 -27.288 1.00 102.38 ? 97  ASN A ND2 1 
ATOM   275  N N   . THR A 1 98  ? -12.296 -20.667 -23.228 1.00 97.68  ? 98  THR A N   1 
ATOM   276  C CA  . THR A 1 98  ? -13.584 -21.147 -22.731 1.00 87.56  ? 98  THR A CA  1 
ATOM   277  C C   . THR A 1 98  ? -14.710 -20.169 -23.072 1.00 94.03  ? 98  THR A C   1 
ATOM   278  O O   . THR A 1 98  ? -15.661 -20.522 -23.783 1.00 96.90  ? 98  THR A O   1 
ATOM   279  C CB  . THR A 1 98  ? -13.516 -21.384 -21.218 1.00 87.53  ? 98  THR A CB  1 
ATOM   280  O OG1 . THR A 1 98  ? -12.560 -22.413 -20.917 1.00 85.51  ? 98  THR A OG1 1 
ATOM   281  C CG2 . THR A 1 98  ? -14.867 -21.803 -20.702 1.00 86.11  ? 98  THR A CG2 1 
ATOM   282  N N   . ILE A 1 99  ? -14.616 -18.927 -22.592 1.00 93.35  ? 99  ILE A N   1 
ATOM   283  C CA  . ILE A 1 99  ? -15.727 -17.987 -22.692 1.00 90.25  ? 99  ILE A CA  1 
ATOM   284  C C   . ILE A 1 99  ? -15.514 -16.887 -23.748 1.00 94.24  ? 99  ILE A C   1 
ATOM   285  O O   . ILE A 1 99  ? -16.511 -16.348 -24.258 1.00 97.70  ? 99  ILE A O   1 
ATOM   286  C CB  . ILE A 1 99  ? -16.046 -17.379 -21.303 1.00 81.74  ? 99  ILE A CB  1 
ATOM   287  C CG1 . ILE A 1 99  ? -16.400 -18.492 -20.320 1.00 82.56  ? 99  ILE A CG1 1 
ATOM   288  C CG2 . ILE A 1 99  ? -17.240 -16.463 -21.320 1.00 74.60  ? 99  ILE A CG2 1 
ATOM   289  C CD1 . ILE A 1 99  ? -17.577 -19.356 -20.738 1.00 79.30  ? 99  ILE A CD1 1 
ATOM   290  N N   . TRP A 1 100 ? -14.254 -16.567 -24.140 1.00 90.57  ? 100 TRP A N   1 
ATOM   291  C CA  . TRP A 1 100 ? -14.032 -15.459 -25.083 1.00 89.92  ? 100 TRP A CA  1 
ATOM   292  C C   . TRP A 1 100 ? -13.271 -15.764 -26.383 1.00 97.82  ? 100 TRP A C   1 
ATOM   293  O O   . TRP A 1 100 ? -12.518 -14.894 -26.844 1.00 96.66  ? 100 TRP A O   1 
ATOM   294  C CB  . TRP A 1 100 ? -13.284 -14.325 -24.364 1.00 89.14  ? 100 TRP A CB  1 
ATOM   295  C CG  . TRP A 1 100 ? -14.044 -13.740 -23.207 1.00 84.48  ? 100 TRP A CG  1 
ATOM   296  C CD1 . TRP A 1 100 ? -13.931 -14.082 -21.888 1.00 79.68  ? 100 TRP A CD1 1 
ATOM   297  C CD2 . TRP A 1 100 ? -15.033 -12.716 -23.269 1.00 79.99  ? 100 TRP A CD2 1 
ATOM   298  N NE1 . TRP A 1 100 ? -14.799 -13.342 -21.134 1.00 69.50  ? 100 TRP A NE1 1 
ATOM   299  C CE2 . TRP A 1 100 ? -15.488 -12.495 -21.957 1.00 70.07  ? 100 TRP A CE2 1 
ATOM   300  C CE3 . TRP A 1 100 ? -15.587 -11.967 -24.313 1.00 83.66  ? 100 TRP A CE3 1 
ATOM   301  C CZ2 . TRP A 1 100 ? -16.456 -11.550 -21.656 1.00 71.79  ? 100 TRP A CZ2 1 
ATOM   302  C CZ3 . TRP A 1 100 ? -16.557 -11.040 -24.017 1.00 78.03  ? 100 TRP A CZ3 1 
ATOM   303  C CH2 . TRP A 1 100 ? -16.980 -10.834 -22.698 1.00 74.92  ? 100 TRP A CH2 1 
ATOM   304  N N   . PRO A 1 101 ? -13.427 -16.954 -27.039 1.00 104.01 ? 101 PRO A N   1 
ATOM   305  C CA  . PRO A 1 101 ? -12.675 -17.181 -28.288 1.00 102.00 ? 101 PRO A CA  1 
ATOM   306  C C   . PRO A 1 101 ? -13.313 -16.542 -29.516 1.00 101.54 ? 101 PRO A C   1 
ATOM   307  O O   . PRO A 1 101 ? -12.603 -16.093 -30.423 1.00 98.83  ? 101 PRO A O   1 
ATOM   308  C CB  . PRO A 1 101 ? -12.655 -18.710 -28.408 1.00 103.92 ? 101 PRO A CB  1 
ATOM   309  C CG  . PRO A 1 101 ? -13.929 -19.132 -27.775 1.00 99.31  ? 101 PRO A CG  1 
ATOM   310  C CD  . PRO A 1 101 ? -14.151 -18.177 -26.629 1.00 100.15 ? 101 PRO A CD  1 
ATOM   311  N N   . SER A 1 102 ? -14.652 -16.512 -29.549 1.00 107.37 ? 102 SER A N   1 
ATOM   312  C CA  . SER A 1 102 ? -15.447 -15.957 -30.647 1.00 111.10 ? 102 SER A CA  1 
ATOM   313  C C   . SER A 1 102 ? -16.802 -15.478 -30.123 1.00 110.40 ? 102 SER A C   1 
ATOM   314  O O   . SER A 1 102 ? -16.895 -15.075 -28.957 1.00 105.76 ? 102 SER A O   1 
ATOM   315  C CB  . SER A 1 102 ? -15.628 -16.996 -31.754 1.00 109.36 ? 102 SER A CB  1 
ATOM   316  O OG  . SER A 1 102 ? -16.511 -18.025 -31.346 1.00 107.02 ? 102 SER A OG  1 
ATOM   317  N N   . GLU A 1 103 ? -17.857 -15.500 -30.953 1.00 108.04 ? 103 GLU A N   1 
ATOM   318  C CA  . GLU A 1 103 ? -19.210 -15.282 -30.439 1.00 110.46 ? 103 GLU A CA  1 
ATOM   319  C C   . GLU A 1 103 ? -20.049 -16.562 -30.479 1.00 112.41 ? 103 GLU A C   1 
ATOM   320  O O   . GLU A 1 103 ? -21.271 -16.507 -30.278 1.00 106.75 ? 103 GLU A O   1 
ATOM   321  C CB  . GLU A 1 103 ? -19.918 -14.101 -31.150 1.00 107.24 ? 103 GLU A CB  1 
ATOM   322  C CG  . GLU A 1 103 ? -21.025 -14.296 -32.241 1.00 107.49 ? 103 GLU A CG  1 
ATOM   323  C CD  . GLU A 1 103 ? -20.670 -15.140 -33.452 1.00 117.68 ? 103 GLU A CD  1 
ATOM   324  O OE1 . GLU A 1 103 ? -19.475 -15.447 -33.664 1.00 122.20 ? 103 GLU A OE1 1 
ATOM   325  O OE2 . GLU A 1 103 ? -21.608 -15.469 -34.219 1.00 113.60 ? 103 GLU A OE2 1 
ATOM   326  N N   . ASP A 1 104 ? -19.398 -17.728 -30.683 1.00 113.73 ? 104 ASP A N   1 
ATOM   327  C CA  . ASP A 1 104 ? -20.002 -19.057 -30.578 1.00 114.66 ? 104 ASP A CA  1 
ATOM   328  C C   . ASP A 1 104 ? -20.286 -19.449 -29.121 1.00 112.53 ? 104 ASP A C   1 
ATOM   329  O O   . ASP A 1 104 ? -21.281 -20.149 -28.873 1.00 112.04 ? 104 ASP A O   1 
ATOM   330  C CB  . ASP A 1 104 ? -19.121 -20.135 -31.243 1.00 114.43 ? 104 ASP A CB  1 
ATOM   331  C CG  . ASP A 1 104 ? -19.421 -20.332 -32.750 1.00 115.42 ? 104 ASP A CG  1 
ATOM   332  O OD1 . ASP A 1 104 ? -20.505 -19.921 -33.233 1.00 109.25 ? 104 ASP A OD1 1 
ATOM   333  O OD2 . ASP A 1 104 ? -18.573 -20.940 -33.447 1.00 106.71 ? 104 ASP A OD2 1 
ATOM   334  N N   . PRO A 1 105 ? -19.454 -19.066 -28.133 1.00 106.55 ? 105 PRO A N   1 
ATOM   335  C CA  . PRO A 1 105 ? -19.839 -19.323 -26.731 1.00 103.75 ? 105 PRO A CA  1 
ATOM   336  C C   . PRO A 1 105 ? -20.936 -18.402 -26.199 1.00 102.70 ? 105 PRO A C   1 
ATOM   337  O O   . PRO A 1 105 ? -21.566 -18.745 -25.188 1.00 95.75  ? 105 PRO A O   1 
ATOM   338  C CB  . PRO A 1 105 ? -18.523 -19.124 -25.963 1.00 101.87 ? 105 PRO A CB  1 
ATOM   339  C CG  . PRO A 1 105 ? -17.467 -19.376 -26.971 1.00 100.30 ? 105 PRO A CG  1 
ATOM   340  C CD  . PRO A 1 105 ? -18.015 -18.751 -28.217 1.00 104.14 ? 105 PRO A CD  1 
ATOM   341  N N   . TRP A 1 106 ? -21.192 -17.258 -26.842 1.00 105.35 ? 106 TRP A N   1 
ATOM   342  C CA  . TRP A 1 106 ? -22.171 -16.278 -26.370 1.00 99.92  ? 106 TRP A CA  1 
ATOM   343  C C   . TRP A 1 106 ? -23.546 -16.419 -27.013 1.00 98.17  ? 106 TRP A C   1 
ATOM   344  O O   . TRP A 1 106 ? -24.539 -16.028 -26.390 1.00 88.91  ? 106 TRP A O   1 
ATOM   345  C CB  . TRP A 1 106 ? -21.645 -14.854 -26.602 1.00 95.89  ? 106 TRP A CB  1 
ATOM   346  C CG  . TRP A 1 106 ? -20.424 -14.520 -25.761 1.00 96.05  ? 106 TRP A CG  1 
ATOM   347  C CD1 . TRP A 1 106 ? -19.147 -14.307 -26.210 1.00 93.87  ? 106 TRP A CD1 1 
ATOM   348  C CD2 . TRP A 1 106 ? -20.381 -14.328 -24.332 1.00 93.37  ? 106 TRP A CD2 1 
ATOM   349  N NE1 . TRP A 1 106 ? -18.314 -14.020 -25.151 1.00 91.58  ? 106 TRP A NE1 1 
ATOM   350  C CE2 . TRP A 1 106 ? -19.046 -14.024 -23.991 1.00 91.10  ? 106 TRP A CE2 1 
ATOM   351  C CE3 . TRP A 1 106 ? -21.341 -14.389 -23.312 1.00 81.96  ? 106 TRP A CE3 1 
ATOM   352  C CZ2 . TRP A 1 106 ? -18.651 -13.777 -22.675 1.00 85.04  ? 106 TRP A CZ2 1 
ATOM   353  C CZ3 . TRP A 1 106 ? -20.944 -14.142 -22.011 1.00 73.83  ? 106 TRP A CZ3 1 
ATOM   354  C CH2 . TRP A 1 106 ? -19.612 -13.840 -21.703 1.00 74.20  ? 106 TRP A CH2 1 
ATOM   355  N N   . LYS A 1 107 ? -23.631 -16.951 -28.246 1.00 104.59 ? 107 LYS A N   1 
ATOM   356  C CA  . LYS A 1 107 ? -24.914 -17.295 -28.858 1.00 102.82 ? 107 LYS A CA  1 
ATOM   357  C C   . LYS A 1 107 ? -25.445 -18.649 -28.385 1.00 101.10 ? 107 LYS A C   1 
ATOM   358  O O   . LYS A 1 107 ? -26.593 -18.994 -28.695 1.00 99.58  ? 107 LYS A O   1 
ATOM   359  C CB  . LYS A 1 107 ? -24.814 -17.267 -30.400 1.00 105.30 ? 107 LYS A CB  1 
ATOM   360  C CG  . LYS A 1 107 ? -26.194 -17.231 -31.119 1.00 109.20 ? 107 LYS A CG  1 
ATOM   361  C CD  . LYS A 1 107 ? -26.296 -16.274 -32.311 1.00 102.32 ? 107 LYS A CD  1 
ATOM   362  C CE  . LYS A 1 107 ? -25.395 -16.679 -33.463 1.00 105.18 ? 107 LYS A CE  1 
ATOM   363  N NZ  . LYS A 1 107 ? -25.288 -15.592 -34.479 1.00 104.35 ? 107 LYS A NZ  1 
ATOM   364  N N   . ALA A 1 108 ? -24.650 -19.415 -27.634 1.00 95.19  ? 108 ALA A N   1 
ATOM   365  C CA  . ALA A 1 108 ? -25.132 -20.627 -26.984 1.00 89.91  ? 108 ALA A CA  1 
ATOM   366  C C   . ALA A 1 108 ? -25.694 -20.347 -25.595 1.00 86.03  ? 108 ALA A C   1 
ATOM   367  O O   . ALA A 1 108 ? -26.711 -20.936 -25.215 1.00 79.91  ? 108 ALA A O   1 
ATOM   368  C CB  . ALA A 1 108 ? -24.010 -21.666 -26.901 1.00 90.56  ? 108 ALA A CB  1 
ATOM   369  N N   . PHE A 1 109 ? -25.050 -19.453 -24.831 1.00 92.12  ? 109 PHE A N   1 
ATOM   370  C CA  . PHE A 1 109 ? -25.573 -19.055 -23.523 1.00 83.73  ? 109 PHE A CA  1 
ATOM   371  C C   . PHE A 1 109 ? -26.988 -18.497 -23.630 1.00 84.60  ? 109 PHE A C   1 
ATOM   372  O O   . PHE A 1 109 ? -27.782 -18.621 -22.687 1.00 77.72  ? 109 PHE A O   1 
ATOM   373  C CB  . PHE A 1 109 ? -24.658 -18.014 -22.868 1.00 72.69  ? 109 PHE A CB  1 
ATOM   374  C CG  . PHE A 1 109 ? -23.493 -18.599 -22.126 1.00 70.49  ? 109 PHE A CG  1 
ATOM   375  C CD1 . PHE A 1 109 ? -23.684 -19.585 -21.171 1.00 68.57  ? 109 PHE A CD1 1 
ATOM   376  C CD2 . PHE A 1 109 ? -22.213 -18.110 -22.326 1.00 77.37  ? 109 PHE A CD2 1 
ATOM   377  C CE1 . PHE A 1 109 ? -22.615 -20.115 -20.468 1.00 65.90  ? 109 PHE A CE1 1 
ATOM   378  C CE2 . PHE A 1 109 ? -21.134 -18.635 -21.623 1.00 74.30  ? 109 PHE A CE2 1 
ATOM   379  C CZ  . PHE A 1 109 ? -21.340 -19.639 -20.690 1.00 69.41  ? 109 PHE A CZ  1 
ATOM   380  N N   . MET A 1 110 ? -27.317 -17.865 -24.760 1.00 89.25  ? 110 MET A N   1 
ATOM   381  C CA  . MET A 1 110 ? -28.671 -17.365 -24.972 1.00 86.18  ? 110 MET A CA  1 
ATOM   382  C C   . MET A 1 110 ? -29.641 -18.514 -25.217 1.00 89.89  ? 110 MET A C   1 
ATOM   383  O O   . MET A 1 110 ? -30.600 -18.704 -24.458 1.00 90.08  ? 110 MET A O   1 
ATOM   384  C CB  . MET A 1 110 ? -28.689 -16.388 -26.147 1.00 80.56  ? 110 MET A CB  1 
ATOM   385  C CG  . MET A 1 110 ? -27.910 -15.119 -25.913 1.00 80.83  ? 110 MET A CG  1 
ATOM   386  S SD  . MET A 1 110 ? -28.070 -13.960 -27.293 1.00 104.35 ? 110 MET A SD  1 
ATOM   387  C CE  . MET A 1 110 ? -26.584 -13.005 -27.055 1.00 86.51  ? 110 MET A CE  1 
ATOM   388  N N   . GLU A 1 111 ? -29.389 -19.311 -26.265 1.00 90.42  ? 111 GLU A N   1 
ATOM   389  C CA  . GLU A 1 111 ? -30.283 -20.374 -26.726 1.00 91.06  ? 111 GLU A CA  1 
ATOM   390  C C   . GLU A 1 111 ? -30.444 -21.511 -25.730 1.00 86.71  ? 111 GLU A C   1 
ATOM   391  O O   . GLU A 1 111 ? -31.240 -22.421 -25.993 1.00 88.28  ? 111 GLU A O   1 
ATOM   392  C CB  . GLU A 1 111 ? -29.789 -20.937 -28.061 1.00 102.05 ? 111 GLU A CB  1 
ATOM   393  C CG  . GLU A 1 111 ? -30.056 -20.025 -29.239 1.00 103.87 ? 111 GLU A CG  1 
ATOM   394  C CD  . GLU A 1 111 ? -29.246 -20.395 -30.455 1.00 108.91 ? 111 GLU A CD  1 
ATOM   395  O OE1 . GLU A 1 111 ? -28.933 -21.599 -30.624 1.00 105.69 ? 111 GLU A OE1 1 
ATOM   396  O OE2 . GLU A 1 111 ? -28.918 -19.471 -31.233 1.00 111.53 ? 111 GLU A OE2 1 
ATOM   397  N N   . GLN A 1 112 ? -29.691 -21.493 -24.630 1.00 84.82  ? 112 GLN A N   1 
ATOM   398  C CA  . GLN A 1 112 ? -29.903 -22.344 -23.462 1.00 78.37  ? 112 GLN A CA  1 
ATOM   399  C C   . GLN A 1 112 ? -30.976 -21.798 -22.517 1.00 84.96  ? 112 GLN A C   1 
ATOM   400  O O   . GLN A 1 112 ? -31.909 -22.527 -22.162 1.00 90.93  ? 112 GLN A O   1 
ATOM   401  C CB  . GLN A 1 112 ? -28.579 -22.541 -22.728 1.00 76.99  ? 112 GLN A CB  1 
ATOM   402  C CG  . GLN A 1 112 ? -28.709 -23.115 -21.350 1.00 75.29  ? 112 GLN A CG  1 
ATOM   403  C CD  . GLN A 1 112 ? -27.943 -22.256 -20.353 1.00 71.90  ? 112 GLN A CD  1 
ATOM   404  O OE1 . GLN A 1 112 ? -27.700 -21.076 -20.611 1.00 68.07  ? 112 GLN A OE1 1 
ATOM   405  N NE2 . GLN A 1 112 ? -27.599 -22.823 -19.201 1.00 63.19  ? 112 GLN A NE2 1 
ATOM   406  N N   . VAL A 1 113 ? -30.876 -20.530 -22.096 1.00 81.54  ? 113 VAL A N   1 
ATOM   407  C CA  . VAL A 1 113 ? -31.945 -19.956 -21.276 1.00 77.32  ? 113 VAL A CA  1 
ATOM   408  C C   . VAL A 1 113 ? -33.250 -19.924 -22.064 1.00 81.69  ? 113 VAL A C   1 
ATOM   409  O O   . VAL A 1 113 ? -34.331 -20.150 -21.505 1.00 80.90  ? 113 VAL A O   1 
ATOM   410  C CB  . VAL A 1 113 ? -31.562 -18.551 -20.757 1.00 80.96  ? 113 VAL A CB  1 
ATOM   411  C CG1 . VAL A 1 113 ? -32.561 -18.078 -19.706 1.00 72.95  ? 113 VAL A CG1 1 
ATOM   412  C CG2 . VAL A 1 113 ? -30.164 -18.541 -20.163 1.00 72.50  ? 113 VAL A CG2 1 
ATOM   413  N N   . GLU A 1 114 ? -33.163 -19.650 -23.378 1.00 90.28  ? 114 GLU A N   1 
ATOM   414  C CA  . GLU A 1 114 ? -34.329 -19.691 -24.271 1.00 91.45  ? 114 GLU A CA  1 
ATOM   415  C C   . GLU A 1 114 ? -35.017 -21.055 -24.249 1.00 93.05  ? 114 GLU A C   1 
ATOM   416  O O   . GLU A 1 114 ? -36.252 -21.134 -24.323 1.00 91.01  ? 114 GLU A O   1 
ATOM   417  C CB  . GLU A 1 114 ? -33.907 -19.365 -25.708 1.00 83.25  ? 114 GLU A CB  1 
ATOM   418  C CG  . GLU A 1 114 ? -33.570 -17.910 -26.005 1.00 91.46  ? 114 GLU A CG  1 
ATOM   419  C CD  . GLU A 1 114 ? -33.258 -17.665 -27.491 1.00 93.81  ? 114 GLU A CD  1 
ATOM   420  O OE1 . GLU A 1 114 ? -32.573 -18.509 -28.111 1.00 86.52  ? 114 GLU A OE1 1 
ATOM   421  O OE2 . GLU A 1 114 ? -33.681 -16.620 -28.034 1.00 95.94  ? 114 GLU A OE2 1 
ATOM   422  N N   . ALA A 1 115 ? -34.233 -22.142 -24.173 1.00 87.46  ? 115 ALA A N   1 
ATOM   423  C CA  . ALA A 1 115 ? -34.798 -23.486 -24.251 1.00 88.72  ? 115 ALA A CA  1 
ATOM   424  C C   . ALA A 1 115 ? -35.556 -23.861 -22.979 1.00 92.32  ? 115 ALA A C   1 
ATOM   425  O O   . ALA A 1 115 ? -36.574 -24.568 -23.044 1.00 90.10  ? 115 ALA A O   1 
ATOM   426  C CB  . ALA A 1 115 ? -33.689 -24.500 -24.530 1.00 81.79  ? 115 ALA A CB  1 
ATOM   427  N N   . LEU A 1 116 ? -35.074 -23.397 -21.822 1.00 89.26  ? 116 LEU A N   1 
ATOM   428  C CA  . LEU A 1 116 ? -35.689 -23.688 -20.533 1.00 81.25  ? 116 LEU A CA  1 
ATOM   429  C C   . LEU A 1 116 ? -36.959 -22.885 -20.297 1.00 82.73  ? 116 LEU A C   1 
ATOM   430  O O   . LEU A 1 116 ? -37.745 -23.248 -19.413 1.00 80.52  ? 116 LEU A O   1 
ATOM   431  C CB  . LEU A 1 116 ? -34.688 -23.386 -19.423 1.00 67.15  ? 116 LEU A CB  1 
ATOM   432  C CG  . LEU A 1 116 ? -33.409 -24.188 -19.566 1.00 63.99  ? 116 LEU A CG  1 
ATOM   433  C CD1 . LEU A 1 116 ? -32.236 -23.556 -18.815 1.00 56.27  ? 116 LEU A CD1 1 
ATOM   434  C CD2 . LEU A 1 116 ? -33.736 -25.548 -19.046 1.00 62.39  ? 116 LEU A CD2 1 
ATOM   435  N N   . MET A 1 117 ? -37.163 -21.807 -21.061 1.00 82.85  ? 117 MET A N   1 
ATOM   436  C CA  . MET A 1 117 ? -38.262 -20.863 -20.872 1.00 84.45  ? 117 MET A CA  1 
ATOM   437  C C   . MET A 1 117 ? -39.403 -21.014 -21.871 1.00 91.06  ? 117 MET A C   1 
ATOM   438  O O   . MET A 1 117 ? -40.535 -20.627 -21.550 1.00 86.12  ? 117 MET A O   1 
ATOM   439  C CB  . MET A 1 117 ? -37.745 -19.416 -20.956 1.00 85.35  ? 117 MET A CB  1 
ATOM   440  C CG  . MET A 1 117 ? -36.866 -18.939 -19.800 1.00 78.83  ? 117 MET A CG  1 
ATOM   441  S SD  . MET A 1 117 ? -37.359 -19.611 -18.202 1.00 68.88  ? 117 MET A SD  1 
ATOM   442  C CE  . MET A 1 117 ? -38.523 -18.355 -17.646 1.00 53.88  ? 117 MET A CE  1 
ATOM   443  N N   . ASP A 1 118 ? -39.135 -21.538 -23.074 1.00 92.66  ? 118 ASP A N   1 
ATOM   444  C CA  . ASP A 1 118 ? -40.076 -21.591 -24.195 1.00 93.10  ? 118 ASP A CA  1 
ATOM   445  C C   . ASP A 1 118 ? -40.432 -20.206 -24.729 1.00 96.04  ? 118 ASP A C   1 
ATOM   446  O O   . ASP A 1 118 ? -41.377 -20.079 -25.520 1.00 96.73  ? 118 ASP A O   1 
ATOM   447  C CB  . ASP A 1 118 ? -41.367 -22.343 -23.833 1.00 101.88 ? 118 ASP A CB  1 
ATOM   448  C CG  . ASP A 1 118 ? -42.056 -22.943 -25.041 1.00 102.70 ? 118 ASP A CG  1 
ATOM   449  O OD1 . ASP A 1 118 ? -41.375 -23.162 -26.067 1.00 99.89  ? 118 ASP A OD1 1 
ATOM   450  O OD2 . ASP A 1 118 ? -43.286 -23.168 -24.965 1.00 103.43 ? 118 ASP A OD2 1 
ATOM   451  N N   . GLN A 1 119 ? -39.713 -19.160 -24.317 1.00 94.28  ? 119 GLN A N   1 
ATOM   452  C CA  . GLN A 1 119 ? -39.857 -17.823 -24.878 1.00 93.91  ? 119 GLN A CA  1 
ATOM   453  C C   . GLN A 1 119 ? -38.626 -17.474 -25.708 1.00 97.55  ? 119 GLN A C   1 
ATOM   454  O O   . GLN A 1 119 ? -37.564 -18.095 -25.578 1.00 92.73  ? 119 GLN A O   1 
ATOM   455  C CB  . GLN A 1 119 ? -40.044 -16.754 -23.788 1.00 87.63  ? 119 GLN A CB  1 
ATOM   456  C CG  . GLN A 1 119 ? -40.883 -17.144 -22.601 1.00 81.82  ? 119 GLN A CG  1 
ATOM   457  C CD  . GLN A 1 119 ? -40.967 -16.019 -21.584 1.00 84.37  ? 119 GLN A CD  1 
ATOM   458  O OE1 . GLN A 1 119 ? -40.658 -16.203 -20.403 1.00 82.55  ? 119 GLN A OE1 1 
ATOM   459  N NE2 . GLN A 1 119 ? -41.373 -14.838 -22.044 1.00 84.74  ? 119 GLN A NE2 1 
ATOM   460  N N   . LYS A 1 120 ? -38.777 -16.445 -26.545 1.00 101.21 ? 120 LYS A N   1 
ATOM   461  C CA  . LYS A 1 120 ? -37.728 -15.958 -27.431 1.00 102.17 ? 120 LYS A CA  1 
ATOM   462  C C   . LYS A 1 120 ? -37.160 -14.621 -26.962 1.00 97.84  ? 120 LYS A C   1 
ATOM   463  O O   . LYS A 1 120 ? -37.879 -13.776 -26.416 1.00 92.01  ? 120 LYS A O   1 
ATOM   464  C CB  . LYS A 1 120 ? -38.242 -15.779 -28.872 1.00 102.16 ? 120 LYS A CB  1 
ATOM   465  C CG  . LYS A 1 120 ? -38.854 -16.986 -29.558 1.00 88.60  ? 120 LYS A CG  1 
ATOM   466  C CD  . LYS A 1 120 ? -38.839 -16.732 -31.058 1.00 88.59  ? 120 LYS A CD  1 
ATOM   467  C CE  . LYS A 1 120 ? -38.753 -18.016 -31.849 1.00 99.66  ? 120 LYS A CE  1 
ATOM   468  N NZ  . LYS A 1 120 ? -38.754 -17.733 -33.306 1.00 99.70  ? 120 LYS A NZ  1 
ATOM   469  N N   . ILE A 1 121 ? -35.855 -14.441 -27.192 1.00 95.02  ? 121 ILE A N   1 
ATOM   470  C CA  . ILE A 1 121 ? -35.286 -13.102 -27.332 1.00 99.61  ? 121 ILE A CA  1 
ATOM   471  C C   . ILE A 1 121 ? -35.520 -12.655 -28.769 1.00 104.82 ? 121 ILE A C   1 
ATOM   472  O O   . ILE A 1 121 ? -35.242 -13.404 -29.718 1.00 98.44  ? 121 ILE A O   1 
ATOM   473  C CB  . ILE A 1 121 ? -33.780 -13.076 -26.988 1.00 101.51 ? 121 ILE A CB  1 
ATOM   474  C CG1 . ILE A 1 121 ? -33.485 -13.658 -25.605 1.00 83.79  ? 121 ILE A CG1 1 
ATOM   475  C CG2 . ILE A 1 121 ? -33.224 -11.648 -27.075 1.00 93.68  ? 121 ILE A CG2 1 
ATOM   476  C CD1 . ILE A 1 121 ? -32.015 -13.957 -25.346 1.00 65.61  ? 121 ILE A CD1 1 
ATOM   477  N N   . ALA A 1 122 ? -36.032 -11.434 -28.935 1.00 103.61 ? 122 ALA A N   1 
ATOM   478  C CA  . ALA A 1 122 ? -36.260 -10.887 -30.265 1.00 102.42 ? 122 ALA A CA  1 
ATOM   479  C C   . ALA A 1 122 ? -34.940 -10.767 -31.019 1.00 111.70 ? 122 ALA A C   1 
ATOM   480  O O   . ALA A 1 122 ? -33.873 -11.081 -30.479 1.00 110.26 ? 122 ALA A O   1 
ATOM   481  C CB  . ALA A 1 122 ? -36.962 -9.530  -30.174 1.00 103.53 ? 122 ALA A CB  1 
ATOM   482  N N   . ASP A 1 123 ? -34.994 -10.321 -32.271 1.00 118.38 ? 123 ASP A N   1 
ATOM   483  C CA  . ASP A 1 123 ? -33.787 -10.206 -33.076 1.00 113.97 ? 123 ASP A CA  1 
ATOM   484  C C   . ASP A 1 123 ? -33.172 -8.809  -33.049 1.00 111.35 ? 123 ASP A C   1 
ATOM   485  O O   . ASP A 1 123 ? -31.974 -8.677  -33.323 1.00 111.97 ? 123 ASP A O   1 
ATOM   486  C CB  . ASP A 1 123 ? -34.075 -10.641 -34.525 1.00 117.82 ? 123 ASP A CB  1 
ATOM   487  C CG  . ASP A 1 123 ? -34.605 -12.088 -34.620 1.00 118.84 ? 123 ASP A CG  1 
ATOM   488  O OD1 . ASP A 1 123 ? -34.172 -12.936 -33.798 1.00 113.37 ? 123 ASP A OD1 1 
ATOM   489  O OD2 . ASP A 1 123 ? -35.442 -12.373 -35.518 1.00 105.65 ? 123 ASP A OD2 1 
ATOM   490  N N   . TYR A 1 124 ? -33.938 -7.769  -32.704 1.00 113.87 ? 124 TYR A N   1 
ATOM   491  C CA  . TYR A 1 124 ? -33.363 -6.437  -32.517 1.00 119.20 ? 124 TYR A CA  1 
ATOM   492  C C   . TYR A 1 124 ? -32.617 -6.300  -31.196 1.00 114.01 ? 124 TYR A C   1 
ATOM   493  O O   . TYR A 1 124 ? -32.107 -5.212  -30.903 1.00 107.21 ? 124 TYR A O   1 
ATOM   494  C CB  . TYR A 1 124 ? -34.454 -5.357  -32.634 1.00 121.67 ? 124 TYR A CB  1 
ATOM   495  C CG  . TYR A 1 124 ? -35.417 -5.252  -31.456 1.00 122.36 ? 124 TYR A CG  1 
ATOM   496  C CD1 . TYR A 1 124 ? -35.152 -4.421  -30.365 1.00 117.06 ? 124 TYR A CD1 1 
ATOM   497  C CD2 . TYR A 1 124 ? -36.603 -5.982  -31.448 1.00 119.28 ? 124 TYR A CD2 1 
ATOM   498  C CE1 . TYR A 1 124 ? -36.045 -4.334  -29.298 1.00 117.26 ? 124 TYR A CE1 1 
ATOM   499  C CE2 . TYR A 1 124 ? -37.495 -5.902  -30.390 1.00 116.48 ? 124 TYR A CE2 1 
ATOM   500  C CZ  . TYR A 1 124 ? -37.217 -5.082  -29.320 1.00 116.16 ? 124 TYR A CZ  1 
ATOM   501  O OH  . TYR A 1 124 ? -38.124 -5.019  -28.281 1.00 109.41 ? 124 TYR A OH  1 
ATOM   502  N N   . ALA A 1 125 ? -32.538 -7.379  -30.412 1.00 108.72 ? 125 ALA A N   1 
ATOM   503  C CA  . ALA A 1 125 ? -31.878 -7.422  -29.113 1.00 101.48 ? 125 ALA A CA  1 
ATOM   504  C C   . ALA A 1 125 ? -30.855 -8.540  -28.994 1.00 98.40  ? 125 ALA A C   1 
ATOM   505  O O   . ALA A 1 125 ? -29.782 -8.322  -28.435 1.00 96.22  ? 125 ALA A O   1 
ATOM   506  C CB  . ALA A 1 125 ? -32.922 -7.573  -28.002 1.00 99.02  ? 125 ALA A CB  1 
ATOM   507  N N   . LYS A 1 126 ? -31.165 -9.734  -29.508 1.00 101.97 ? 126 LYS A N   1 
ATOM   508  C CA  . LYS A 1 126 ? -30.208 -10.840 -29.576 1.00 99.13  ? 126 LYS A CA  1 
ATOM   509  C C   . LYS A 1 126 ? -28.930 -10.493 -30.351 1.00 98.28  ? 126 LYS A C   1 
ATOM   510  O O   . LYS A 1 126 ? -27.942 -11.232 -30.248 1.00 94.68  ? 126 LYS A O   1 
ATOM   511  C CB  . LYS A 1 126 ? -30.917 -12.053 -30.197 1.00 108.27 ? 126 LYS A CB  1 
ATOM   512  C CG  . LYS A 1 126 ? -30.205 -13.397 -30.145 1.00 108.12 ? 126 LYS A CG  1 
ATOM   513  C CD  . LYS A 1 126 ? -31.200 -14.498 -30.525 1.00 105.33 ? 126 LYS A CD  1 
ATOM   514  C CE  . LYS A 1 126 ? -30.527 -15.666 -31.249 1.00 108.29 ? 126 LYS A CE  1 
ATOM   515  N NZ  . LYS A 1 126 ? -29.294 -16.177 -30.593 1.00 114.41 ? 126 LYS A NZ  1 
ATOM   516  N N   . ASN A 1 127 ? -28.919 -9.396  -31.120 1.00 102.68 ? 127 ASN A N   1 
ATOM   517  C CA  . ASN A 1 127 ? -27.712 -8.970  -31.834 1.00 99.64  ? 127 ASN A CA  1 
ATOM   518  C C   . ASN A 1 127 ? -26.825 -8.084  -30.963 1.00 93.60  ? 127 ASN A C   1 
ATOM   519  O O   . ASN A 1 127 ? -25.704 -8.471  -30.622 1.00 94.40  ? 127 ASN A O   1 
ATOM   520  C CB  . ASN A 1 127 ? -28.063 -8.229  -33.133 1.00 96.98  ? 127 ASN A CB  1 
ATOM   521  C CG  . ASN A 1 127 ? -28.894 -9.064  -34.086 1.00 97.43  ? 127 ASN A CG  1 
ATOM   522  O OD1 . ASN A 1 127 ? -29.740 -8.530  -34.805 1.00 100.01 ? 127 ASN A OD1 1 
ATOM   523  N ND2 . ASN A 1 127 ? -28.668 -10.374 -34.094 1.00 94.00  ? 127 ASN A ND2 1 
ATOM   524  N N   . LYS A 1 128 ? -27.318 -6.897  -30.587 1.00 91.21  ? 128 LYS A N   1 
ATOM   525  C CA  . LYS A 1 128 ? -26.533 -5.976  -29.765 1.00 89.71  ? 128 LYS A CA  1 
ATOM   526  C C   . LYS A 1 128 ? -26.041 -6.610  -28.455 1.00 93.00  ? 128 LYS A C   1 
ATOM   527  O O   . LYS A 1 128 ? -25.204 -6.014  -27.768 1.00 89.92  ? 128 LYS A O   1 
ATOM   528  C CB  . LYS A 1 128 ? -27.348 -4.696  -29.500 1.00 81.50  ? 128 LYS A CB  1 
ATOM   529  C CG  . LYS A 1 128 ? -26.546 -3.572  -28.819 1.00 84.37  ? 128 LYS A CG  1 
ATOM   530  C CD  . LYS A 1 128 ? -27.124 -2.182  -29.029 1.00 79.02  ? 128 LYS A CD  1 
ATOM   531  C CE  . LYS A 1 128 ? -26.482 -1.173  -28.074 1.00 73.73  ? 128 LYS A CE  1 
ATOM   532  N NZ  . LYS A 1 128 ? -24.996 -1.110  -28.150 1.00 70.92  ? 128 LYS A NZ  1 
ATOM   533  N N   . ALA A 1 129 ? -26.509 -7.809  -28.101 1.00 88.66  ? 129 ALA A N   1 
ATOM   534  C CA  . ALA A 1 129 ? -25.863 -8.570  -27.041 1.00 83.90  ? 129 ALA A CA  1 
ATOM   535  C C   . ALA A 1 129 ? -24.645 -9.339  -27.527 1.00 86.07  ? 129 ALA A C   1 
ATOM   536  O O   . ALA A 1 129 ? -23.786 -9.690  -26.714 1.00 83.05  ? 129 ALA A O   1 
ATOM   537  C CB  . ALA A 1 129 ? -26.848 -9.547  -26.409 1.00 84.69  ? 129 ALA A CB  1 
ATOM   538  N N   . LEU A 1 130 ? -24.550 -9.612  -28.826 1.00 89.38  ? 130 LEU A N   1 
ATOM   539  C CA  . LEU A 1 130 ? -23.377 -10.272 -29.390 1.00 90.12  ? 130 LEU A CA  1 
ATOM   540  C C   . LEU A 1 130 ? -22.355 -9.272  -29.908 1.00 84.58  ? 130 LEU A C   1 
ATOM   541  O O   . LEU A 1 130 ? -21.145 -9.521  -29.821 1.00 77.09  ? 130 LEU A O   1 
ATOM   542  C CB  . LEU A 1 130 ? -23.798 -11.211 -30.522 1.00 94.25  ? 130 LEU A CB  1 
ATOM   543  C CG  . LEU A 1 130 ? -24.721 -12.349 -30.108 1.00 98.18  ? 130 LEU A CG  1 
ATOM   544  C CD1 . LEU A 1 130 ? -25.367 -12.975 -31.329 1.00 92.87  ? 130 LEU A CD1 1 
ATOM   545  C CD2 . LEU A 1 130 ? -23.904 -13.367 -29.312 1.00 100.88 ? 130 LEU A CD2 1 
ATOM   546  N N   . ALA A 1 131 ? -22.841 -8.149  -30.459 1.00 85.67  ? 131 ALA A N   1 
ATOM   547  C CA  . ALA A 1 131 ? -21.985 -7.048  -30.892 1.00 85.74  ? 131 ALA A CA  1 
ATOM   548  C C   . ALA A 1 131 ? -21.188 -6.471  -29.742 1.00 87.08  ? 131 ALA A C   1 
ATOM   549  O O   . ALA A 1 131 ? -20.119 -5.885  -29.964 1.00 83.68  ? 131 ALA A O   1 
ATOM   550  C CB  . ALA A 1 131 ? -22.822 -5.937  -31.523 1.00 76.24  ? 131 ALA A CB  1 
ATOM   551  N N   . GLU A 1 132 ? -21.691 -6.621  -28.520 1.00 84.48  ? 132 GLU A N   1 
ATOM   552  C CA  . GLU A 1 132 ? -20.955 -6.160  -27.361 1.00 77.31  ? 132 GLU A CA  1 
ATOM   553  C C   . GLU A 1 132 ? -20.016 -7.238  -26.841 1.00 72.44  ? 132 GLU A C   1 
ATOM   554  O O   . GLU A 1 132 ? -18.880 -6.939  -26.470 1.00 73.86  ? 132 GLU A O   1 
ATOM   555  C CB  . GLU A 1 132 ? -21.933 -5.710  -26.277 1.00 75.18  ? 132 GLU A CB  1 
ATOM   556  C CG  . GLU A 1 132 ? -22.828 -4.547  -26.703 1.00 74.90  ? 132 GLU A CG  1 
ATOM   557  C CD  . GLU A 1 132 ? -22.215 -3.181  -26.437 1.00 76.76  ? 132 GLU A CD  1 
ATOM   558  O OE1 . GLU A 1 132 ? -20.991 -3.119  -26.212 1.00 74.19  ? 132 GLU A OE1 1 
ATOM   559  O OE2 . GLU A 1 132 ? -22.958 -2.166  -26.449 1.00 82.27  ? 132 GLU A OE2 1 
ATOM   560  N N   . LEU A 1 133 ? -20.442 -8.499  -26.851 1.00 64.99  ? 133 LEU A N   1 
ATOM   561  C CA  . LEU A 1 133 ? -19.540 -9.554  -26.405 1.00 74.16  ? 133 LEU A CA  1 
ATOM   562  C C   . LEU A 1 133 ? -18.404 -9.827  -27.385 1.00 86.02  ? 133 LEU A C   1 
ATOM   563  O O   . LEU A 1 133 ? -17.435 -10.505 -27.016 1.00 83.77  ? 133 LEU A O   1 
ATOM   564  C CB  . LEU A 1 133 ? -20.304 -10.832 -26.167 1.00 76.80  ? 133 LEU A CB  1 
ATOM   565  C CG  . LEU A 1 133 ? -21.095 -10.667 -24.897 1.00 77.19  ? 133 LEU A CG  1 
ATOM   566  C CD1 . LEU A 1 133 ? -22.284 -11.547 -25.032 1.00 84.23  ? 133 LEU A CD1 1 
ATOM   567  C CD2 . LEU A 1 133 ? -20.258 -11.014 -23.704 1.00 71.69  ? 133 LEU A CD2 1 
ATOM   568  N N   . GLN A 1 134 ? -18.524 -9.381  -28.639 1.00 86.69  ? 134 GLN A N   1 
ATOM   569  C CA  . GLN A 1 134 ? -17.328 -9.174  -29.449 1.00 88.11  ? 134 GLN A CA  1 
ATOM   570  C C   . GLN A 1 134 ? -16.492 -8.026  -28.906 1.00 84.57  ? 134 GLN A C   1 
ATOM   571  O O   . GLN A 1 134 ? -15.281 -8.188  -28.673 1.00 83.65  ? 134 GLN A O   1 
ATOM   572  C CB  . GLN A 1 134 ? -17.688 -8.931  -30.918 1.00 93.19  ? 134 GLN A CB  1 
ATOM   573  C CG  . GLN A 1 134 ? -18.050 -10.188 -31.699 1.00 104.59 ? 134 GLN A CG  1 
ATOM   574  C CD  . GLN A 1 134 ? -16.828 -11.093 -31.871 1.00 105.49 ? 134 GLN A CD  1 
ATOM   575  O OE1 . GLN A 1 134 ? -16.529 -11.938 -31.019 1.00 105.37 ? 134 GLN A OE1 1 
ATOM   576  N NE2 . GLN A 1 134 ? -16.084 -10.876 -32.958 1.00 97.74  ? 134 GLN A NE2 1 
ATOM   577  N N   . GLY A 1 135 ? -17.123 -6.857  -28.703 1.00 84.29  ? 135 GLY A N   1 
ATOM   578  C CA  . GLY A 1 135 ? -16.393 -5.718  -28.170 1.00 84.64  ? 135 GLY A CA  1 
ATOM   579  C C   . GLY A 1 135 ? -15.559 -6.085  -26.962 1.00 79.44  ? 135 GLY A C   1 
ATOM   580  O O   . GLY A 1 135 ? -14.416 -5.642  -26.821 1.00 78.31  ? 135 GLY A O   1 
ATOM   581  N N   . LEU A 1 136 ? -16.082 -6.981  -26.137 1.00 76.09  ? 136 LEU A N   1 
ATOM   582  C CA  . LEU A 1 136 ? -15.433 -7.342  -24.898 1.00 72.98  ? 136 LEU A CA  1 
ATOM   583  C C   . LEU A 1 136 ? -14.405 -8.452  -25.093 1.00 75.36  ? 136 LEU A C   1 
ATOM   584  O O   . LEU A 1 136 ? -13.484 -8.583  -24.275 1.00 72.31  ? 136 LEU A O   1 
ATOM   585  C CB  . LEU A 1 136 ? -16.502 -7.740  -23.892 1.00 62.84  ? 136 LEU A CB  1 
ATOM   586  C CG  . LEU A 1 136 ? -17.485 -6.597  -23.653 1.00 59.83  ? 136 LEU A CG  1 
ATOM   587  C CD1 . LEU A 1 136 ? -18.749 -7.086  -22.986 1.00 56.87  ? 136 LEU A CD1 1 
ATOM   588  C CD2 . LEU A 1 136 ? -16.845 -5.501  -22.825 1.00 57.07  ? 136 LEU A CD2 1 
ATOM   589  N N   . GLN A 1 137 ? -14.524 -9.238  -26.165 1.00 77.74  ? 137 GLN A N   1 
ATOM   590  C CA  . GLN A 1 137 ? -13.489 -10.218 -26.478 1.00 82.92  ? 137 GLN A CA  1 
ATOM   591  C C   . GLN A 1 137 ? -12.121 -9.557  -26.598 1.00 77.86  ? 137 GLN A C   1 
ATOM   592  O O   . GLN A 1 137 ? -11.160 -9.935  -25.919 1.00 70.55  ? 137 GLN A O   1 
ATOM   593  C CB  . GLN A 1 137 ? -13.815 -10.948 -27.778 1.00 85.16  ? 137 GLN A CB  1 
ATOM   594  C CG  . GLN A 1 137 ? -12.636 -11.800 -28.216 1.00 92.62  ? 137 GLN A CG  1 
ATOM   595  C CD  . GLN A 1 137 ? -12.928 -12.685 -29.404 1.00 104.11 ? 137 GLN A CD  1 
ATOM   596  O OE1 . GLN A 1 137 ? -13.983 -13.315 -29.488 1.00 105.38 ? 137 GLN A OE1 1 
ATOM   597  N NE2 . GLN A 1 137 ? -11.981 -12.727 -30.350 1.00 101.32 ? 137 GLN A NE2 1 
ATOM   598  N N   . ASN A 1 138 ? -12.021 -8.574  -27.485 1.00 80.24  ? 138 ASN A N   1 
ATOM   599  C CA  . ASN A 1 138 ? -10.735 -8.021  -27.877 1.00 81.20  ? 138 ASN A CA  1 
ATOM   600  C C   . ASN A 1 138 ? -10.042 -7.440  -26.657 1.00 74.69  ? 138 ASN A C   1 
ATOM   601  O O   . ASN A 1 138 ? -9.046  -7.988  -26.166 1.00 67.93  ? 138 ASN A O   1 
ATOM   602  C CB  . ASN A 1 138 ? -10.934 -6.959  -28.963 1.00 81.88  ? 138 ASN A CB  1 
ATOM   603  C CG  . ASN A 1 138 ? -11.470 -7.550  -30.254 1.00 86.25  ? 138 ASN A CG  1 
ATOM   604  O OD1 . ASN A 1 138 ? -11.561 -8.778  -30.396 1.00 90.51  ? 138 ASN A OD1 1 
ATOM   605  N ND2 . ASN A 1 138 ? -11.862 -6.686  -31.186 1.00 84.93  ? 138 ASN A ND2 1 
ATOM   606  N N   . ASN A 1 139 ? -10.579 -6.319  -26.192 1.00 70.24  ? 139 ASN A N   1 
ATOM   607  C CA  . ASN A 1 139 ? -10.319 -5.735  -24.890 1.00 61.37  ? 139 ASN A CA  1 
ATOM   608  C C   . ASN A 1 139 ? -9.751  -6.729  -23.880 1.00 58.23  ? 139 ASN A C   1 
ATOM   609  O O   . ASN A 1 139 ? -8.611  -6.572  -23.438 1.00 59.01  ? 139 ASN A O   1 
ATOM   610  C CB  . ASN A 1 139 ? -11.634 -5.131  -24.426 1.00 63.94  ? 139 ASN A CB  1 
ATOM   611  C CG  . ASN A 1 139 ? -12.033 -3.941  -25.281 1.00 69.01  ? 139 ASN A CG  1 
ATOM   612  O OD1 . ASN A 1 139 ? -11.181 -3.142  -25.662 1.00 76.51  ? 139 ASN A OD1 1 
ATOM   613  N ND2 . ASN A 1 139 ? -13.309 -3.846  -25.632 1.00 70.24  ? 139 ASN A ND2 1 
ATOM   614  N N   . VAL A 1 140 ? -10.510 -7.775  -23.544 1.00 55.60  ? 140 VAL A N   1 
ATOM   615  C CA  . VAL A 1 140 ? -10.049 -8.750  -22.558 1.00 53.90  ? 140 VAL A CA  1 
ATOM   616  C C   . VAL A 1 140 ? -8.850  -9.544  -23.063 1.00 63.25  ? 140 VAL A C   1 
ATOM   617  O O   . VAL A 1 140 ? -7.914  -9.822  -22.308 1.00 59.39  ? 140 VAL A O   1 
ATOM   618  C CB  . VAL A 1 140 ? -11.193 -9.687  -22.176 1.00 56.58  ? 140 VAL A CB  1 
ATOM   619  C CG1 . VAL A 1 140 ? -10.629 -10.879 -21.434 1.00 57.46  ? 140 VAL A CG1 1 
ATOM   620  C CG2 . VAL A 1 140 ? -12.184 -8.947  -21.326 1.00 54.63  ? 140 VAL A CG2 1 
ATOM   621  N N   . GLU A 1 141 ? -8.883  -9.975  -24.327 1.00 69.65  ? 141 GLU A N   1 
ATOM   622  C CA  . GLU A 1 141 ? -7.725  -10.625 -24.939 1.00 65.72  ? 141 GLU A CA  1 
ATOM   623  C C   . GLU A 1 141 ? -6.500  -9.712  -24.898 1.00 59.35  ? 141 GLU A C   1 
ATOM   624  O O   . GLU A 1 141 ? -5.468  -10.058 -24.312 1.00 58.09  ? 141 GLU A O   1 
ATOM   625  C CB  . GLU A 1 141 ? -8.061  -11.023 -26.386 1.00 74.31  ? 141 GLU A CB  1 
ATOM   626  C CG  . GLU A 1 141 ? -9.021  -12.218 -26.525 1.00 86.98  ? 141 GLU A CG  1 
ATOM   627  C CD  . GLU A 1 141 ? -8.945  -12.931 -27.884 1.00 86.29  ? 141 GLU A CD  1 
ATOM   628  O OE1 . GLU A 1 141 ? -8.253  -12.438 -28.802 1.00 86.05  ? 141 GLU A OE1 1 
ATOM   629  O OE2 . GLU A 1 141 ? -9.595  -13.988 -28.030 1.00 82.09  ? 141 GLU A OE2 1 
ATOM   630  N N   . ASP A 1 142 ? -6.609  -8.531  -25.518 1.00 57.25  ? 142 ASP A N   1 
ATOM   631  C CA  . ASP A 1 142 ? -5.520  -7.554  -25.509 1.00 58.59  ? 142 ASP A CA  1 
ATOM   632  C C   . ASP A 1 142 ? -4.988  -7.263  -24.104 1.00 57.00  ? 142 ASP A C   1 
ATOM   633  O O   . ASP A 1 142 ? -3.774  -7.112  -23.921 1.00 58.53  ? 142 ASP A O   1 
ATOM   634  C CB  . ASP A 1 142 ? -5.966  -6.239  -26.166 1.00 65.55  ? 142 ASP A CB  1 
ATOM   635  C CG  . ASP A 1 142 ? -6.219  -6.368  -27.651 1.00 62.16  ? 142 ASP A CG  1 
ATOM   636  O OD1 . ASP A 1 142 ? -5.399  -7.014  -28.324 1.00 68.94  ? 142 ASP A OD1 1 
ATOM   637  O OD2 . ASP A 1 142 ? -7.224  -5.819  -28.146 1.00 60.55  ? 142 ASP A OD2 1 
ATOM   638  N N   . TYR A 1 143 ? -5.866  -7.124  -23.104 1.00 54.95  ? 143 TYR A N   1 
ATOM   639  C CA  . TYR A 1 143 ? -5.341  -6.862  -21.768 1.00 52.23  ? 143 TYR A CA  1 
ATOM   640  C C   . TYR A 1 143 ? -4.500  -8.041  -21.276 1.00 49.70  ? 143 TYR A C   1 
ATOM   641  O O   . TYR A 1 143 ? -3.415  -7.846  -20.716 1.00 41.74  ? 143 TYR A O   1 
ATOM   642  C CB  . TYR A 1 143 ? -6.461  -6.541  -20.769 1.00 50.32  ? 143 TYR A CB  1 
ATOM   643  C CG  . TYR A 1 143 ? -5.952  -6.604  -19.335 1.00 42.82  ? 143 TYR A CG  1 
ATOM   644  C CD1 . TYR A 1 143 ? -5.092  -5.633  -18.832 1.00 39.92  ? 143 TYR A CD1 1 
ATOM   645  C CD2 . TYR A 1 143 ? -6.269  -7.665  -18.520 1.00 42.81  ? 143 TYR A CD2 1 
ATOM   646  C CE1 . TYR A 1 143 ? -4.591  -5.714  -17.553 1.00 38.30  ? 143 TYR A CE1 1 
ATOM   647  C CE2 . TYR A 1 143 ? -5.779  -7.754  -17.247 1.00 43.23  ? 143 TYR A CE2 1 
ATOM   648  C CZ  . TYR A 1 143 ? -4.939  -6.786  -16.761 1.00 43.23  ? 143 TYR A CZ  1 
ATOM   649  O OH  . TYR A 1 143 ? -4.465  -6.906  -15.468 1.00 45.32  ? 143 TYR A OH  1 
ATOM   650  N N   . VAL A 1 144 ? -4.967  -9.273  -21.519 1.00 52.50  ? 144 VAL A N   1 
ATOM   651  C CA  . VAL A 1 144 ? -4.292  -10.460 -20.995 1.00 55.09  ? 144 VAL A CA  1 
ATOM   652  C C   . VAL A 1 144 ? -2.934  -10.666 -21.660 1.00 58.90  ? 144 VAL A C   1 
ATOM   653  O O   . VAL A 1 144 ? -1.948  -11.029 -20.992 1.00 53.44  ? 144 VAL A O   1 
ATOM   654  C CB  . VAL A 1 144 ? -5.189  -11.698 -21.154 1.00 56.27  ? 144 VAL A CB  1 
ATOM   655  C CG1 . VAL A 1 144 ? -4.432  -12.943 -20.746 1.00 65.55  ? 144 VAL A CG1 1 
ATOM   656  C CG2 . VAL A 1 144 ? -6.383  -11.545 -20.291 1.00 58.54  ? 144 VAL A CG2 1 
ATOM   657  N N   . SER A 1 145 ? -2.863  -10.478 -22.985 1.00 56.79  ? 145 SER A N   1 
ATOM   658  C CA  . SER A 1 145 ? -1.567  -10.485 -23.653 1.00 54.92  ? 145 SER A CA  1 
ATOM   659  C C   . SER A 1 145 ? -0.615  -9.517  -22.959 1.00 54.51  ? 145 SER A C   1 
ATOM   660  O O   . SER A 1 145 ? 0.437   -9.921  -22.449 1.00 55.45  ? 145 SER A O   1 
ATOM   661  C CB  . SER A 1 145 ? -1.736  -10.134 -25.129 1.00 59.26  ? 145 SER A CB  1 
ATOM   662  O OG  . SER A 1 145 ? -1.739  -8.728  -25.316 1.00 65.57  ? 145 SER A OG  1 
ATOM   663  N N   . ALA A 1 146 ? -1.019  -8.245  -22.861 1.00 51.31  ? 146 ALA A N   1 
ATOM   664  C CA  . ALA A 1 146 ? -0.225  -7.231  -22.169 1.00 53.14  ? 146 ALA A CA  1 
ATOM   665  C C   . ALA A 1 146 ? 0.152   -7.655  -20.752 1.00 51.42  ? 146 ALA A C   1 
ATOM   666  O O   . ALA A 1 146 ? 1.316   -7.549  -20.355 1.00 49.59  ? 146 ALA A O   1 
ATOM   667  C CB  . ALA A 1 146 ? -0.995  -5.917  -22.131 1.00 52.00  ? 146 ALA A CB  1 
ATOM   668  N N   . LEU A 1 147 ? -0.824  -8.113  -19.965 1.00 52.20  ? 147 LEU A N   1 
ATOM   669  C CA  . LEU A 1 147 ? -0.533  -8.509  -18.592 1.00 46.41  ? 147 LEU A CA  1 
ATOM   670  C C   . LEU A 1 147 ? 0.447   -9.668  -18.553 1.00 52.91  ? 147 LEU A C   1 
ATOM   671  O O   . LEU A 1 147 ? 1.352   -9.698  -17.711 1.00 54.46  ? 147 LEU A O   1 
ATOM   672  C CB  . LEU A 1 147 ? -1.823  -8.869  -17.861 1.00 45.20  ? 147 LEU A CB  1 
ATOM   673  C CG  . LEU A 1 147 ? -1.703  -9.448  -16.449 1.00 48.50  ? 147 LEU A CG  1 
ATOM   674  C CD1 . LEU A 1 147 ? -1.028  -8.442  -15.552 1.00 53.57  ? 147 LEU A CD1 1 
ATOM   675  C CD2 . LEU A 1 147 ? -3.064  -9.795  -15.882 1.00 45.53  ? 147 LEU A CD2 1 
ATOM   676  N N   . SER A 1 148 ? 0.298   -10.626 -19.469 1.00 58.82  ? 148 SER A N   1 
ATOM   677  C CA  . SER A 1 148 ? 1.243   -11.740 -19.524 1.00 61.47  ? 148 SER A CA  1 
ATOM   678  C C   . SER A 1 148 ? 2.668   -11.251 -19.752 1.00 61.25  ? 148 SER A C   1 
ATOM   679  O O   . SER A 1 148 ? 3.606   -11.707 -19.087 1.00 59.11  ? 148 SER A O   1 
ATOM   680  C CB  . SER A 1 148 ? 0.833   -12.715 -20.621 1.00 58.91  ? 148 SER A CB  1 
ATOM   681  O OG  . SER A 1 148 ? 1.392   -13.993 -20.371 1.00 66.84  ? 148 SER A OG  1 
ATOM   682  N N   . SER A 1 149 ? 2.846   -10.327 -20.701 1.00 59.32  ? 149 SER A N   1 
ATOM   683  C CA  . SER A 1 149 ? 4.147   -9.716  -20.931 1.00 57.20  ? 149 SER A CA  1 
ATOM   684  C C   . SER A 1 149 ? 4.670   -9.054  -19.669 1.00 64.74  ? 149 SER A C   1 
ATOM   685  O O   . SER A 1 149 ? 5.833   -9.239  -19.292 1.00 67.31  ? 149 SER A O   1 
ATOM   686  C CB  . SER A 1 149 ? 4.037   -8.689  -22.051 1.00 58.84  ? 149 SER A CB  1 
ATOM   687  O OG  . SER A 1 149 ? 3.452   -9.264  -23.201 1.00 71.58  ? 149 SER A OG  1 
ATOM   688  N N   . TRP A 1 150 ? 3.818   -8.260  -19.017 1.00 62.46  ? 150 TRP A N   1 
ATOM   689  C CA  . TRP A 1 150 ? 4.178   -7.594  -17.772 1.00 61.64  ? 150 TRP A CA  1 
ATOM   690  C C   . TRP A 1 150 ? 4.743   -8.572  -16.753 1.00 65.83  ? 150 TRP A C   1 
ATOM   691  O O   . TRP A 1 150 ? 5.756   -8.292  -16.094 1.00 63.64  ? 150 TRP A O   1 
ATOM   692  C CB  . TRP A 1 150 ? 2.944   -6.910  -17.198 1.00 58.92  ? 150 TRP A CB  1 
ATOM   693  C CG  . TRP A 1 150 ? 3.269   -5.967  -16.120 1.00 60.64  ? 150 TRP A CG  1 
ATOM   694  C CD1 . TRP A 1 150 ? 3.125   -6.170  -14.772 1.00 57.25  ? 150 TRP A CD1 1 
ATOM   695  C CD2 . TRP A 1 150 ? 3.787   -4.649  -16.280 1.00 57.28  ? 150 TRP A CD2 1 
ATOM   696  N NE1 . TRP A 1 150 ? 3.536   -5.055  -14.084 1.00 59.06  ? 150 TRP A NE1 1 
ATOM   697  C CE2 . TRP A 1 150 ? 3.947   -4.105  -14.985 1.00 59.89  ? 150 TRP A CE2 1 
ATOM   698  C CE3 . TRP A 1 150 ? 4.139   -3.876  -17.390 1.00 54.96  ? 150 TRP A CE3 1 
ATOM   699  C CZ2 . TRP A 1 150 ? 4.439   -2.822  -14.771 1.00 54.85  ? 150 TRP A CZ2 1 
ATOM   700  C CZ3 . TRP A 1 150 ? 4.633   -2.597  -17.180 1.00 64.65  ? 150 TRP A CZ3 1 
ATOM   701  C CH2 . TRP A 1 150 ? 4.781   -2.084  -15.878 1.00 64.51  ? 150 TRP A CH2 1 
ATOM   702  N N   . GLN A 1 151 ? 4.088   -9.729  -16.620 1.00 67.29  ? 151 GLN A N   1 
ATOM   703  C CA  . GLN A 1 151 ? 4.490   -10.754 -15.663 1.00 64.36  ? 151 GLN A CA  1 
ATOM   704  C C   . GLN A 1 151 ? 5.863   -11.326 -16.015 1.00 69.84  ? 151 GLN A C   1 
ATOM   705  O O   . GLN A 1 151 ? 6.751   -11.418 -15.156 1.00 68.91  ? 151 GLN A O   1 
ATOM   706  C CB  . GLN A 1 151 ? 3.428   -11.851 -15.646 1.00 63.29  ? 151 GLN A CB  1 
ATOM   707  C CG  . GLN A 1 151 ? 2.363   -11.650 -14.598 1.00 64.77  ? 151 GLN A CG  1 
ATOM   708  C CD  . GLN A 1 151 ? 2.860   -11.889 -13.189 1.00 81.04  ? 151 GLN A CD  1 
ATOM   709  O OE1 . GLN A 1 151 ? 3.456   -12.937 -12.895 1.00 88.55  ? 151 GLN A OE1 1 
ATOM   710  N NE2 . GLN A 1 151 ? 2.661   -10.898 -12.312 1.00 73.06  ? 151 GLN A NE2 1 
ATOM   711  N N   . LYS A 1 152 ? 6.055   -11.701 -17.285 1.00 73.54  ? 152 LYS A N   1 
ATOM   712  C CA  . LYS A 1 152 ? 7.333   -12.245 -17.740 1.00 77.38  ? 152 LYS A CA  1 
ATOM   713  C C   . LYS A 1 152 ? 8.430   -11.179 -17.716 1.00 77.26  ? 152 LYS A C   1 
ATOM   714  O O   . LYS A 1 152 ? 9.412   -11.305 -16.971 1.00 70.16  ? 152 LYS A O   1 
ATOM   715  C CB  . LYS A 1 152 ? 7.160   -12.853 -19.141 1.00 80.00  ? 152 LYS A CB  1 
ATOM   716  C CG  . LYS A 1 152 ? 8.325   -13.724 -19.658 1.00 86.22  ? 152 LYS A CG  1 
ATOM   717  C CD  . LYS A 1 152 ? 7.954   -14.351 -21.016 1.00 89.91  ? 152 LYS A CD  1 
ATOM   718  C CE  . LYS A 1 152 ? 8.997   -15.336 -21.529 1.00 86.50  ? 152 LYS A CE  1 
ATOM   719  N NZ  . LYS A 1 152 ? 8.399   -16.207 -22.592 1.00 87.25  ? 152 LYS A NZ  1 
ATOM   720  N N   . ASN A 1 153 ? 8.271   -10.104 -18.529 1.00 76.77  ? 153 ASN A N   1 
ATOM   721  C CA  . ASN A 1 153 ? 9.239   -9.011  -18.674 1.00 81.34  ? 153 ASN A CA  1 
ATOM   722  C C   . ASN A 1 153 ? 9.942   -8.659  -17.368 1.00 88.03  ? 153 ASN A C   1 
ATOM   723  O O   . ASN A 1 153 ? 9.300   -8.197  -16.409 1.00 85.14  ? 153 ASN A O   1 
ATOM   724  C CB  . ASN A 1 153 ? 8.580   -7.743  -19.229 1.00 80.54  ? 153 ASN A CB  1 
ATOM   725  C CG  . ASN A 1 153 ? 8.338   -7.814  -20.723 1.00 82.99  ? 153 ASN A CG  1 
ATOM   726  O OD1 . ASN A 1 153 ? 8.692   -8.802  -21.373 1.00 83.42  ? 153 ASN A OD1 1 
ATOM   727  N ND2 . ASN A 1 153 ? 7.755   -6.752  -21.284 1.00 78.53  ? 153 ASN A ND2 1 
ATOM   728  N N   . PRO A 1 154 ? 11.256  -8.878  -17.301 1.00 86.99  ? 154 PRO A N   1 
ATOM   729  C CA  . PRO A 1 154 ? 12.004  -8.530  -16.088 1.00 84.90  ? 154 PRO A CA  1 
ATOM   730  C C   . PRO A 1 154 ? 11.916  -7.042  -15.796 1.00 89.59  ? 154 PRO A C   1 
ATOM   731  O O   . PRO A 1 154 ? 11.775  -6.219  -16.700 1.00 93.18  ? 154 PRO A O   1 
ATOM   732  C CB  . PRO A 1 154 ? 13.436  -8.962  -16.420 1.00 93.17  ? 154 PRO A CB  1 
ATOM   733  C CG  . PRO A 1 154 ? 13.254  -10.076 -17.455 1.00 87.79  ? 154 PRO A CG  1 
ATOM   734  C CD  . PRO A 1 154 ? 12.066  -9.645  -18.268 1.00 79.37  ? 154 PRO A CD  1 
ATOM   735  N N   . VAL A 1 155 ? 12.013  -6.703  -14.510 1.00 98.37  ? 155 VAL A N   1 
ATOM   736  C CA  . VAL A 1 155 ? 11.714  -5.359  -14.007 1.00 96.40  ? 155 VAL A CA  1 
ATOM   737  C C   . VAL A 1 155 ? 12.712  -4.342  -14.557 1.00 96.48  ? 155 VAL A C   1 
ATOM   738  O O   . VAL A 1 155 ? 12.614  -3.142  -14.272 1.00 97.94  ? 155 VAL A O   1 
ATOM   739  C CB  . VAL A 1 155 ? 11.695  -5.349  -12.464 1.00 93.59  ? 155 VAL A CB  1 
ATOM   740  C CG1 . VAL A 1 155 ? 11.063  -4.069  -11.919 1.00 98.28  ? 155 VAL A CG1 1 
ATOM   741  C CG2 . VAL A 1 155 ? 10.926  -6.544  -11.948 1.00 90.98  ? 155 VAL A CG2 1 
ATOM   742  N N   . SER A 1 156 ? 13.690  -4.811  -15.337 1.00 97.98  ? 156 SER A N   1 
ATOM   743  C CA  . SER A 1 156 ? 14.459  -3.937  -16.212 1.00 102.97 ? 156 SER A CA  1 
ATOM   744  C C   . SER A 1 156 ? 13.721  -3.630  -17.541 1.00 105.64 ? 156 SER A C   1 
ATOM   745  O O   . SER A 1 156 ? 14.357  -3.189  -18.512 1.00 107.72 ? 156 SER A O   1 
ATOM   746  C CB  . SER A 1 156 ? 15.838  -4.541  -16.483 1.00 100.94 ? 156 SER A CB  1 
ATOM   747  O OG  . SER A 1 156 ? 15.751  -5.911  -16.830 1.00 104.38 ? 156 SER A OG  1 
ATOM   748  N N   . SER A 1 157 ? 12.391  -3.838  -17.576 1.00 98.69  ? 157 SER A N   1 
ATOM   749  C CA  . SER A 1 157 ? 11.535  -3.508  -18.710 1.00 94.89  ? 157 SER A CA  1 
ATOM   750  C C   . SER A 1 157 ? 10.531  -2.403  -18.408 1.00 93.20  ? 157 SER A C   1 
ATOM   751  O O   . SER A 1 157 ? 9.956   -1.841  -19.347 1.00 93.94  ? 157 SER A O   1 
ATOM   752  C CB  . SER A 1 157 ? 10.768  -4.764  -19.179 1.00 91.73  ? 157 SER A CB  1 
ATOM   753  O OG  . SER A 1 157 ? 9.819   -4.477  -20.204 1.00 88.85  ? 157 SER A OG  1 
ATOM   754  N N   . ARG A 1 158 ? 10.323  -2.059  -17.138 1.00 87.93  ? 158 ARG A N   1 
ATOM   755  C CA  . ARG A 1 158 ? 9.107   -1.360  -16.719 1.00 86.10  ? 158 ARG A CA  1 
ATOM   756  C C   . ARG A 1 158 ? 9.278   0.164   -16.818 1.00 87.08  ? 158 ARG A C   1 
ATOM   757  O O   . ARG A 1 158 ? 9.160   0.928   -15.851 1.00 84.52  ? 158 ARG A O   1 
ATOM   758  C CB  . ARG A 1 158 ? 8.722   -1.820  -15.319 1.00 86.02  ? 158 ARG A CB  1 
ATOM   759  C CG  . ARG A 1 158 ? 8.626   -3.338  -15.268 1.00 84.16  ? 158 ARG A CG  1 
ATOM   760  C CD  . ARG A 1 158 ? 8.126   -3.880  -13.958 1.00 76.80  ? 158 ARG A CD  1 
ATOM   761  N NE  . ARG A 1 158 ? 7.635   -5.238  -14.147 1.00 79.65  ? 158 ARG A NE  1 
ATOM   762  C CZ  . ARG A 1 158 ? 6.958   -5.932  -13.236 1.00 82.77  ? 158 ARG A CZ  1 
ATOM   763  N NH1 . ARG A 1 158 ? 6.657   -5.386  -12.063 1.00 76.91  ? 158 ARG A NH1 1 
ATOM   764  N NH2 . ARG A 1 158 ? 6.564   -7.171  -13.509 1.00 80.41  ? 158 ARG A NH2 1 
ATOM   765  N N   . ASN A 1 159 ? 9.539   0.593   -18.052 1.00 78.54  ? 159 ASN A N   1 
ATOM   766  C CA  . ASN A 1 159 ? 9.665   1.992   -18.407 1.00 76.95  ? 159 ASN A CA  1 
ATOM   767  C C   . ASN A 1 159 ? 8.300   2.679   -18.433 1.00 73.89  ? 159 ASN A C   1 
ATOM   768  O O   . ASN A 1 159 ? 7.260   2.023   -18.449 1.00 68.90  ? 159 ASN A O   1 
ATOM   769  C CB  . ASN A 1 159 ? 10.339  2.100   -19.771 1.00 77.69  ? 159 ASN A CB  1 
ATOM   770  C CG  . ASN A 1 159 ? 9.605   1.312   -20.837 1.00 72.97  ? 159 ASN A CG  1 
ATOM   771  O OD1 . ASN A 1 159 ? 8.512   1.674   -21.237 1.00 70.04  ? 159 ASN A OD1 1 
ATOM   772  N ND2 . ASN A 1 159 ? 10.212  0.230   -21.305 1.00 75.02  ? 159 ASN A ND2 1 
ATOM   773  N N   . PRO A 1 160 ? 8.270   4.016   -18.444 1.00 75.25  ? 160 PRO A N   1 
ATOM   774  C CA  . PRO A 1 160 ? 6.981   4.716   -18.588 1.00 69.55  ? 160 PRO A CA  1 
ATOM   775  C C   . PRO A 1 160 ? 6.192   4.343   -19.840 1.00 67.16  ? 160 PRO A C   1 
ATOM   776  O O   . PRO A 1 160 ? 4.970   4.539   -19.857 1.00 61.26  ? 160 PRO A O   1 
ATOM   777  C CB  . PRO A 1 160 ? 7.388   6.196   -18.601 1.00 62.13  ? 160 PRO A CB  1 
ATOM   778  C CG  . PRO A 1 160 ? 8.634   6.235   -17.816 1.00 69.51  ? 160 PRO A CG  1 
ATOM   779  C CD  . PRO A 1 160 ? 9.359   4.946   -18.100 1.00 75.71  ? 160 PRO A CD  1 
ATOM   780  N N   . HIS A 1 161 ? 6.828   3.807   -20.883 1.00 72.35  ? 161 HIS A N   1 
ATOM   781  C CA  . HIS A 1 161 ? 6.099   3.555   -22.127 1.00 75.27  ? 161 HIS A CA  1 
ATOM   782  C C   . HIS A 1 161 ? 5.087   2.428   -21.925 1.00 70.80  ? 161 HIS A C   1 
ATOM   783  O O   . HIS A 1 161 ? 3.877   2.622   -22.082 1.00 68.91  ? 161 HIS A O   1 
ATOM   784  C CB  . HIS A 1 161 ? 7.080   3.219   -23.266 1.00 76.03  ? 161 HIS A CB  1 
ATOM   785  C CG  . HIS A 1 161 ? 7.537   4.407   -24.069 1.00 98.15  ? 161 HIS A CG  1 
ATOM   786  N ND1 . HIS A 1 161 ? 6.669   5.278   -24.695 1.00 107.34 ? 161 HIS A ND1 1 
ATOM   787  C CD2 . HIS A 1 161 ? 8.785   4.851   -24.361 1.00 106.72 ? 161 HIS A CD2 1 
ATOM   788  C CE1 . HIS A 1 161 ? 7.363   6.214   -25.322 1.00 112.17 ? 161 HIS A CE1 1 
ATOM   789  N NE2 . HIS A 1 161 ? 8.648   5.976   -25.137 1.00 110.26 ? 161 HIS A NE2 1 
ATOM   790  N N   . SER A 1 162 ? 5.572   1.242   -21.532 1.00 72.40  ? 162 SER A N   1 
ATOM   791  C CA  . SER A 1 162 ? 4.705   0.081   -21.334 1.00 62.49  ? 162 SER A CA  1 
ATOM   792  C C   . SER A 1 162 ? 3.761   0.253   -20.139 1.00 60.07  ? 162 SER A C   1 
ATOM   793  O O   . SER A 1 162 ? 2.682   -0.345  -20.124 1.00 55.98  ? 162 SER A O   1 
ATOM   794  C CB  . SER A 1 162 ? 5.570   -1.177  -21.188 1.00 55.47  ? 162 SER A CB  1 
ATOM   795  O OG  . SER A 1 162 ? 6.592   -1.038  -20.215 1.00 51.88  ? 162 SER A OG  1 
ATOM   796  N N   . GLN A 1 163 ? 4.136   1.059   -19.138 1.00 62.67  ? 163 GLN A N   1 
ATOM   797  C CA  . GLN A 1 163 ? 3.251   1.293   -18.001 1.00 52.65  ? 163 GLN A CA  1 
ATOM   798  C C   . GLN A 1 163 ? 1.920   1.845   -18.470 1.00 56.60  ? 163 GLN A C   1 
ATOM   799  O O   . GLN A 1 163 ? 0.871   1.227   -18.277 1.00 64.08  ? 163 GLN A O   1 
ATOM   800  C CB  . GLN A 1 163 ? 3.854   2.281   -17.004 1.00 55.50  ? 163 GLN A CB  1 
ATOM   801  C CG  . GLN A 1 163 ? 4.623   1.705   -15.836 1.00 58.41  ? 163 GLN A CG  1 
ATOM   802  C CD  . GLN A 1 163 ? 5.118   2.793   -14.901 1.00 62.37  ? 163 GLN A CD  1 
ATOM   803  O OE1 . GLN A 1 163 ? 5.451   3.905   -15.335 1.00 61.64  ? 163 GLN A OE1 1 
ATOM   804  N NE2 . GLN A 1 163 ? 5.186   2.474   -13.602 1.00 61.34  ? 163 GLN A NE2 1 
ATOM   805  N N   . GLY A 1 164 ? 1.942   3.035   -19.060 1.00 52.00  ? 164 GLY A N   1 
ATOM   806  C CA  . GLY A 1 164 ? 0.707   3.626   -19.521 1.00 49.84  ? 164 GLY A CA  1 
ATOM   807  C C   . GLY A 1 164 ? 0.059   2.908   -20.676 1.00 50.09  ? 164 GLY A C   1 
ATOM   808  O O   . GLY A 1 164 ? -1.033  3.300   -21.111 1.00 44.85  ? 164 GLY A O   1 
ATOM   809  N N   . ARG A 1 165 ? 0.723   1.884   -21.203 1.00 49.12  ? 165 ARG A N   1 
ATOM   810  C CA  . ARG A 1 165 ? 0.121   1.077   -22.240 1.00 51.36  ? 165 ARG A CA  1 
ATOM   811  C C   . ARG A 1 165 ? -0.767  -0.010  -21.625 1.00 55.61  ? 165 ARG A C   1 
ATOM   812  O O   . ARG A 1 165 ? -1.957  -0.090  -21.942 1.00 58.21  ? 165 ARG A O   1 
ATOM   813  C CB  . ARG A 1 165 ? 1.222   0.510   -23.137 1.00 53.70  ? 165 ARG A CB  1 
ATOM   814  C CG  . ARG A 1 165 ? 0.717   -0.323  -24.294 1.00 64.16  ? 165 ARG A CG  1 
ATOM   815  C CD  . ARG A 1 165 ? 1.743   -1.415  -24.568 1.00 71.93  ? 165 ARG A CD  1 
ATOM   816  N NE  . ARG A 1 165 ? 1.200   -2.549  -25.317 1.00 70.88  ? 165 ARG A NE  1 
ATOM   817  C CZ  . ARG A 1 165 ? 1.751   -3.760  -25.291 1.00 66.45  ? 165 ARG A CZ  1 
ATOM   818  N NH1 . ARG A 1 165 ? 2.841   -3.972  -24.564 1.00 69.77  ? 165 ARG A NH1 1 
ATOM   819  N NH2 . ARG A 1 165 ? 1.222   -4.760  -25.976 1.00 63.88  ? 165 ARG A NH2 1 
ATOM   820  N N   . ILE A 1 166 ? -0.241  -0.826  -20.705 1.00 51.02  ? 166 ILE A N   1 
ATOM   821  C CA  . ILE A 1 166 ? -1.130  -1.712  -19.956 1.00 43.68  ? 166 ILE A CA  1 
ATOM   822  C C   . ILE A 1 166 ? -2.174  -0.902  -19.200 1.00 46.96  ? 166 ILE A C   1 
ATOM   823  O O   . ILE A 1 166 ? -3.347  -1.279  -19.138 1.00 48.98  ? 166 ILE A O   1 
ATOM   824  C CB  . ILE A 1 166 ? -0.338  -2.638  -19.018 1.00 36.70  ? 166 ILE A CB  1 
ATOM   825  C CG1 . ILE A 1 166 ? -1.249  -3.746  -18.509 1.00 40.41  ? 166 ILE A CG1 1 
ATOM   826  C CG2 . ILE A 1 166 ? 0.269   -1.903  -17.874 1.00 40.58  ? 166 ILE A CG2 1 
ATOM   827  C CD1 . ILE A 1 166 ? -0.509  -4.896  -17.889 1.00 49.35  ? 166 ILE A CD1 1 
ATOM   828  N N   . ARG A 1 167 ? -1.780  0.235   -18.636 1.00 46.91  ? 167 ARG A N   1 
ATOM   829  C CA  . ARG A 1 167 ? -2.765  1.104   -18.010 1.00 45.38  ? 167 ARG A CA  1 
ATOM   830  C C   . ARG A 1 167 ? -3.923  1.384   -18.955 1.00 46.30  ? 167 ARG A C   1 
ATOM   831  O O   . ARG A 1 167 ? -5.085  1.289   -18.558 1.00 46.28  ? 167 ARG A O   1 
ATOM   832  C CB  . ARG A 1 167 ? -2.131  2.417   -17.566 1.00 45.16  ? 167 ARG A CB  1 
ATOM   833  C CG  . ARG A 1 167 ? -1.613  2.460   -16.168 1.00 45.07  ? 167 ARG A CG  1 
ATOM   834  C CD  . ARG A 1 167 ? -1.865  3.881   -15.657 1.00 46.55  ? 167 ARG A CD  1 
ATOM   835  N NE  . ARG A 1 167 ? -1.258  4.888   -16.523 1.00 51.70  ? 167 ARG A NE  1 
ATOM   836  C CZ  . ARG A 1 167 ? -0.003  5.293   -16.394 1.00 49.59  ? 167 ARG A CZ  1 
ATOM   837  N NH1 . ARG A 1 167 ? 0.729   4.806   -15.402 1.00 44.19  ? 167 ARG A NH1 1 
ATOM   838  N NH2 . ARG A 1 167 ? 0.509   6.194   -17.230 1.00 49.32  ? 167 ARG A NH2 1 
ATOM   839  N N   . GLU A 1 168 ? -3.629  1.724   -20.220 1.00 51.85  ? 168 GLU A N   1 
ATOM   840  C CA  . GLU A 1 168 ? -4.729  2.052   -21.120 1.00 56.14  ? 168 GLU A CA  1 
ATOM   841  C C   . GLU A 1 168 ? -5.494  0.796   -21.486 1.00 56.78  ? 168 GLU A C   1 
ATOM   842  O O   . GLU A 1 168 ? -6.723  0.835   -21.620 1.00 56.70  ? 168 GLU A O   1 
ATOM   843  C CB  . GLU A 1 168 ? -4.269  2.751   -22.412 1.00 58.49  ? 168 GLU A CB  1 
ATOM   844  C CG  . GLU A 1 168 ? -3.407  1.887   -23.319 1.00 60.45  ? 168 GLU A CG  1 
ATOM   845  C CD  . GLU A 1 168 ? -3.359  2.324   -24.785 1.00 69.37  ? 168 GLU A CD  1 
ATOM   846  O OE1 . GLU A 1 168 ? -3.695  3.500   -25.081 1.00 70.19  ? 168 GLU A OE1 1 
ATOM   847  O OE2 . GLU A 1 168 ? -2.999  1.461   -25.637 1.00 63.71  ? 168 GLU A OE2 1 
ATOM   848  N N   . LEU A 1 169 ? -4.793  -0.328  -21.622 1.00 48.61  ? 169 LEU A N   1 
ATOM   849  C CA  . LEU A 1 169 ? -5.479  -1.569  -21.937 1.00 48.00  ? 169 LEU A CA  1 
ATOM   850  C C   . LEU A 1 169 ? -6.474  -1.918  -20.841 1.00 46.08  ? 169 LEU A C   1 
ATOM   851  O O   . LEU A 1 169 ? -7.673  -2.037  -21.096 1.00 45.64  ? 169 LEU A O   1 
ATOM   852  C CB  . LEU A 1 169 ? -4.462  -2.687  -22.164 1.00 50.44  ? 169 LEU A CB  1 
ATOM   853  C CG  . LEU A 1 169 ? -3.745  -2.548  -23.519 1.00 52.27  ? 169 LEU A CG  1 
ATOM   854  C CD1 . LEU A 1 169 ? -3.068  -3.835  -23.940 1.00 47.31  ? 169 LEU A CD1 1 
ATOM   855  C CD2 . LEU A 1 169 ? -4.707  -2.062  -24.615 1.00 53.60  ? 169 LEU A CD2 1 
ATOM   856  N N   . PHE A 1 170 ? -6.001  -2.027  -19.599 1.00 48.05  ? 170 PHE A N   1 
ATOM   857  C CA  . PHE A 1 170 ? -6.909  -2.261  -18.478 1.00 43.31  ? 170 PHE A CA  1 
ATOM   858  C C   . PHE A 1 170 ? -8.037  -1.236  -18.441 1.00 45.64  ? 170 PHE A C   1 
ATOM   859  O O   . PHE A 1 170 ? -9.197  -1.586  -18.202 1.00 45.65  ? 170 PHE A O   1 
ATOM   860  C CB  . PHE A 1 170 ? -6.146  -2.230  -17.161 1.00 36.73  ? 170 PHE A CB  1 
ATOM   861  C CG  . PHE A 1 170 ? -7.005  -2.495  -15.960 1.00 34.47  ? 170 PHE A CG  1 
ATOM   862  C CD1 . PHE A 1 170 ? -7.772  -1.491  -15.398 1.00 35.44  ? 170 PHE A CD1 1 
ATOM   863  C CD2 . PHE A 1 170 ? -7.011  -3.735  -15.367 1.00 36.38  ? 170 PHE A CD2 1 
ATOM   864  C CE1 . PHE A 1 170 ? -8.565  -1.732  -14.302 1.00 33.15  ? 170 PHE A CE1 1 
ATOM   865  C CE2 . PHE A 1 170 ? -7.794  -3.986  -14.253 1.00 36.05  ? 170 PHE A CE2 1 
ATOM   866  C CZ  . PHE A 1 170 ? -8.580  -2.985  -13.721 1.00 31.91  ? 170 PHE A CZ  1 
ATOM   867  N N   . SER A 1 171 ? -7.721  0.040   -18.648 1.00 43.44  ? 171 SER A N   1 
ATOM   868  C CA  . SER A 1 171 ? -8.780  1.037   -18.610 1.00 45.35  ? 171 SER A CA  1 
ATOM   869  C C   . SER A 1 171 ? -9.773  0.833   -19.736 1.00 52.33  ? 171 SER A C   1 
ATOM   870  O O   . SER A 1 171 ? -10.964 1.119   -19.564 1.00 49.48  ? 171 SER A O   1 
ATOM   871  C CB  . SER A 1 171 ? -8.194  2.442   -18.684 1.00 51.81  ? 171 SER A CB  1 
ATOM   872  O OG  . SER A 1 171 ? -7.927  2.936   -17.380 1.00 59.43  ? 171 SER A OG  1 
ATOM   873  N N   . GLN A 1 172 ? -9.301  0.351   -20.892 1.00 55.89  ? 172 GLN A N   1 
ATOM   874  C CA  . GLN A 1 172 ? -10.163 0.172   -22.059 1.00 56.44  ? 172 GLN A CA  1 
ATOM   875  C C   . GLN A 1 172 ? -11.229 -0.833  -21.677 1.00 50.63  ? 172 GLN A C   1 
ATOM   876  O O   . GLN A 1 172 ? -12.417 -0.509  -21.586 1.00 50.19  ? 172 GLN A O   1 
ATOM   877  C CB  . GLN A 1 172 ? -9.414  -0.393  -23.275 1.00 60.88  ? 172 GLN A CB  1 
ATOM   878  C CG  . GLN A 1 172 ? -8.444  0.520   -24.002 1.00 71.35  ? 172 GLN A CG  1 
ATOM   879  C CD  . GLN A 1 172 ? -9.115  1.701   -24.674 1.00 94.64  ? 172 GLN A CD  1 
ATOM   880  O OE1 . GLN A 1 172 ? -9.335  2.741   -24.040 1.00 91.41  ? 172 GLN A OE1 1 
ATOM   881  N NE2 . GLN A 1 172 ? -9.454  1.549   -25.951 1.00 99.15  ? 172 GLN A NE2 1 
ATOM   882  N N   . ALA A 1 173 ? -10.763 -2.071  -21.474 1.00 48.20  ? 173 ALA A N   1 
ATOM   883  C CA  . ALA A 1 173 ? -11.565 -3.214  -21.074 1.00 43.34  ? 173 ALA A CA  1 
ATOM   884  C C   . ALA A 1 173 ? -12.548 -2.857  -19.974 1.00 42.92  ? 173 ALA A C   1 
ATOM   885  O O   . ALA A 1 173 ? -13.766 -2.961  -20.146 1.00 43.83  ? 173 ALA A O   1 
ATOM   886  C CB  . ALA A 1 173 ? -10.620 -4.326  -20.618 1.00 42.51  ? 173 ALA A CB  1 
ATOM   887  N N   . GLU A 1 174 ? -12.026 -2.436  -18.827 1.00 39.25  ? 174 GLU A N   1 
ATOM   888  C CA  . GLU A 1 174 ? -12.903 -2.103  -17.724 1.00 39.33  ? 174 GLU A CA  1 
ATOM   889  C C   . GLU A 1 174 ? -13.941 -1.068  -18.156 1.00 42.19  ? 174 GLU A C   1 
ATOM   890  O O   . GLU A 1 174 ? -15.133 -1.216  -17.870 1.00 42.21  ? 174 GLU A O   1 
ATOM   891  C CB  . GLU A 1 174 ? -12.071 -1.605  -16.547 1.00 39.86  ? 174 GLU A CB  1 
ATOM   892  C CG  . GLU A 1 174 ? -12.774 -1.698  -15.212 1.00 31.85  ? 174 GLU A CG  1 
ATOM   893  C CD  . GLU A 1 174 ? -13.768 -0.588  -14.987 1.00 39.57  ? 174 GLU A CD  1 
ATOM   894  O OE1 . GLU A 1 174 ? -13.537 0.562   -15.448 1.00 45.03  ? 174 GLU A OE1 1 
ATOM   895  O OE2 . GLU A 1 174 ? -14.797 -0.875  -14.343 1.00 41.03  ? 174 GLU A OE2 1 
ATOM   896  N N   . SER A 1 175 ? -13.508 -0.018  -18.868 1.00 46.51  ? 175 SER A N   1 
ATOM   897  C CA  . SER A 1 175 ? -14.459 0.965   -19.385 1.00 47.39  ? 175 SER A CA  1 
ATOM   898  C C   . SER A 1 175 ? -15.551 0.297   -20.202 1.00 43.84  ? 175 SER A C   1 
ATOM   899  O O   . SER A 1 175 ? -16.741 0.587   -20.032 1.00 45.45  ? 175 SER A O   1 
ATOM   900  C CB  . SER A 1 175 ? -13.741 2.009   -20.238 1.00 57.28  ? 175 SER A CB  1 
ATOM   901  O OG  . SER A 1 175 ? -14.618 3.057   -20.631 1.00 65.20  ? 175 SER A OG  1 
ATOM   902  N N   . HIS A 1 176 ? -15.163 -0.629  -21.066 1.00 45.66  ? 176 HIS A N   1 
ATOM   903  C CA  . HIS A 1 176 ? -16.114 -1.208  -22.002 1.00 53.12  ? 176 HIS A CA  1 
ATOM   904  C C   . HIS A 1 176 ? -17.152 -2.068  -21.295 1.00 49.62  ? 176 HIS A C   1 
ATOM   905  O O   . HIS A 1 176 ? -18.339 -2.021  -21.642 1.00 53.62  ? 176 HIS A O   1 
ATOM   906  C CB  . HIS A 1 176 ? -15.366 -2.004  -23.069 1.00 55.69  ? 176 HIS A CB  1 
ATOM   907  C CG  . HIS A 1 176 ? -16.105 -2.098  -24.364 1.00 67.19  ? 176 HIS A CG  1 
ATOM   908  N ND1 . HIS A 1 176 ? -17.238 -2.869  -24.520 1.00 66.39  ? 176 HIS A ND1 1 
ATOM   909  C CD2 . HIS A 1 176 ? -15.920 -1.458  -25.543 1.00 74.99  ? 176 HIS A CD2 1 
ATOM   910  C CE1 . HIS A 1 176 ? -17.684 -2.746  -25.758 1.00 69.30  ? 176 HIS A CE1 1 
ATOM   911  N NE2 . HIS A 1 176 ? -16.909 -1.888  -26.397 1.00 77.24  ? 176 HIS A NE2 1 
ATOM   912  N N   . PHE A 1 177 ? -16.733 -2.851  -20.301 1.00 48.22  ? 177 PHE A N   1 
ATOM   913  C CA  . PHE A 1 177 ? -17.701 -3.604  -19.511 1.00 43.63  ? 177 PHE A CA  1 
ATOM   914  C C   . PHE A 1 177 ? -18.741 -2.680  -18.928 1.00 38.85  ? 177 PHE A C   1 
ATOM   915  O O   . PHE A 1 177 ? -19.930 -2.983  -18.943 1.00 43.61  ? 177 PHE A O   1 
ATOM   916  C CB  . PHE A 1 177 ? -16.996 -4.363  -18.396 1.00 37.48  ? 177 PHE A CB  1 
ATOM   917  C CG  . PHE A 1 177 ? -16.495 -5.688  -18.822 1.00 36.09  ? 177 PHE A CG  1 
ATOM   918  C CD1 . PHE A 1 177 ? -17.329 -6.793  -18.823 1.00 42.30  ? 177 PHE A CD1 1 
ATOM   919  C CD2 . PHE A 1 177 ? -15.211 -5.822  -19.290 1.00 33.30  ? 177 PHE A CD2 1 
ATOM   920  C CE1 . PHE A 1 177 ? -16.866 -8.028  -19.238 1.00 42.98  ? 177 PHE A CE1 1 
ATOM   921  C CE2 . PHE A 1 177 ? -14.741 -7.041  -19.715 1.00 39.04  ? 177 PHE A CE2 1 
ATOM   922  C CZ  . PHE A 1 177 ? -15.566 -8.151  -19.687 1.00 44.63  ? 177 PHE A CZ  1 
ATOM   923  N N   . ARG A 1 178 ? -18.312 -1.530  -18.438 1.00 42.87  ? 178 ARG A N   1 
ATOM   924  C CA  . ARG A 1 178 ? -19.254 -0.657  -17.778 1.00 44.47  ? 178 ARG A CA  1 
ATOM   925  C C   . ARG A 1 178 ? -20.270 -0.115  -18.755 1.00 48.26  ? 178 ARG A C   1 
ATOM   926  O O   . ARG A 1 178 ? -21.432 0.075   -18.379 1.00 48.61  ? 178 ARG A O   1 
ATOM   927  C CB  . ARG A 1 178 ? -18.516 0.465   -17.080 1.00 48.33  ? 178 ARG A CB  1 
ATOM   928  C CG  . ARG A 1 178 ? -17.670 -0.061  -15.954 1.00 42.02  ? 178 ARG A CG  1 
ATOM   929  C CD  . ARG A 1 178 ? -17.315 1.035   -14.982 1.00 46.17  ? 178 ARG A CD  1 
ATOM   930  N NE  . ARG A 1 178 ? -16.530 2.125   -15.543 1.00 47.48  ? 178 ARG A NE  1 
ATOM   931  C CZ  . ARG A 1 178 ? -17.009 3.355   -15.678 1.00 45.48  ? 178 ARG A CZ  1 
ATOM   932  N NH1 . ARG A 1 178 ? -18.265 3.613   -15.319 1.00 34.07  ? 178 ARG A NH1 1 
ATOM   933  N NH2 . ARG A 1 178 ? -16.241 4.311   -16.187 1.00 50.37  ? 178 ARG A NH2 1 
ATOM   934  N N   . ASN A 1 179 ? -19.857 0.114   -20.012 1.00 53.08  ? 179 ASN A N   1 
ATOM   935  C CA  . ASN A 1 179 ? -20.802 0.533   -21.051 1.00 54.42  ? 179 ASN A CA  1 
ATOM   936  C C   . ASN A 1 179 ? -21.693 -0.608  -21.522 1.00 55.55  ? 179 ASN A C   1 
ATOM   937  O O   . ASN A 1 179 ? -22.874 -0.392  -21.814 1.00 57.63  ? 179 ASN A O   1 
ATOM   938  C CB  . ASN A 1 179 ? -20.075 1.113   -22.250 1.00 56.35  ? 179 ASN A CB  1 
ATOM   939  C CG  . ASN A 1 179 ? -20.041 2.606   -22.217 1.00 82.89  ? 179 ASN A CG  1 
ATOM   940  O OD1 . ASN A 1 179 ? -20.933 3.258   -22.772 1.00 93.07  ? 179 ASN A OD1 1 
ATOM   941  N ND2 . ASN A 1 179 ? -19.004 3.175   -21.598 1.00 87.27  ? 179 ASN A ND2 1 
ATOM   942  N N   . SER A 1 180 ? -21.139 -1.820  -21.630 1.00 49.51  ? 180 SER A N   1 
ATOM   943  C CA  . SER A 1 180 ? -21.891 -2.945  -22.171 1.00 47.43  ? 180 SER A CA  1 
ATOM   944  C C   . SER A 1 180 ? -23.038 -3.343  -21.261 1.00 45.77  ? 180 SER A C   1 
ATOM   945  O O   . SER A 1 180 ? -24.159 -3.540  -21.731 1.00 51.59  ? 180 SER A O   1 
ATOM   946  C CB  . SER A 1 180 ? -20.979 -4.150  -22.380 1.00 50.29  ? 180 SER A CB  1 
ATOM   947  O OG  . SER A 1 180 ? -19.929 -3.853  -23.268 1.00 58.30  ? 180 SER A OG  1 
ATOM   948  N N   . MET A 1 181 ? -22.776 -3.472  -19.960 1.00 43.27  ? 181 MET A N   1 
ATOM   949  C CA  . MET A 1 181 ? -23.615 -4.299  -19.090 1.00 41.24  ? 181 MET A CA  1 
ATOM   950  C C   . MET A 1 181 ? -25.114 -4.094  -19.269 1.00 44.05  ? 181 MET A C   1 
ATOM   951  O O   . MET A 1 181 ? -25.816 -5.096  -19.475 1.00 45.04  ? 181 MET A O   1 
ATOM   952  C CB  . MET A 1 181 ? -23.219 -4.111  -17.620 1.00 37.71  ? 181 MET A CB  1 
ATOM   953  C CG  . MET A 1 181 ? -21.975 -4.882  -17.172 1.00 31.59  ? 181 MET A CG  1 
ATOM   954  S SD  . MET A 1 181 ? -21.914 -6.629  -17.658 1.00 41.66  ? 181 MET A SD  1 
ATOM   955  C CE  . MET A 1 181 ? -23.303 -7.339  -16.804 1.00 36.09  ? 181 MET A CE  1 
ATOM   956  N N   . PRO A 1 182 ? -25.678 -2.862  -19.242 1.00 44.92  ? 182 PRO A N   1 
ATOM   957  C CA  . PRO A 1 182 ? -27.141 -2.755  -19.375 1.00 44.17  ? 182 PRO A CA  1 
ATOM   958  C C   . PRO A 1 182 ? -27.682 -3.406  -20.642 1.00 48.14  ? 182 PRO A C   1 
ATOM   959  O O   . PRO A 1 182 ? -28.870 -3.716  -20.703 1.00 54.60  ? 182 PRO A O   1 
ATOM   960  C CB  . PRO A 1 182 ? -27.400 -1.245  -19.363 1.00 40.01  ? 182 PRO A CB  1 
ATOM   961  C CG  . PRO A 1 182 ? -26.119 -0.609  -18.949 1.00 47.06  ? 182 PRO A CG  1 
ATOM   962  C CD  . PRO A 1 182 ? -25.029 -1.541  -19.312 1.00 47.20  ? 182 PRO A CD  1 
ATOM   963  N N   . SER A 1 183 ? -26.831 -3.639  -21.648 1.00 45.11  ? 183 SER A N   1 
ATOM   964  C CA  . SER A 1 183 ? -27.255 -4.404  -22.817 1.00 47.60  ? 183 SER A CA  1 
ATOM   965  C C   . SER A 1 183 ? -27.678 -5.814  -22.447 1.00 52.93  ? 183 SER A C   1 
ATOM   966  O O   . SER A 1 183 ? -28.463 -6.438  -23.171 1.00 56.72  ? 183 SER A O   1 
ATOM   967  C CB  . SER A 1 183 ? -26.135 -4.483  -23.857 1.00 54.36  ? 183 SER A CB  1 
ATOM   968  O OG  . SER A 1 183 ? -25.894 -3.222  -24.452 1.00 71.75  ? 183 SER A OG  1 
ATOM   969  N N   . PHE A 1 184 ? -27.146 -6.354  -21.359 1.00 50.91  ? 184 PHE A N   1 
ATOM   970  C CA  . PHE A 1 184 ? -27.543 -7.677  -20.919 1.00 43.71  ? 184 PHE A CA  1 
ATOM   971  C C   . PHE A 1 184 ? -28.624 -7.633  -19.856 1.00 44.09  ? 184 PHE A C   1 
ATOM   972  O O   . PHE A 1 184 ? -28.894 -8.662  -19.231 1.00 43.32  ? 184 PHE A O   1 
ATOM   973  C CB  . PHE A 1 184 ? -26.342 -8.447  -20.406 1.00 41.27  ? 184 PHE A CB  1 
ATOM   974  C CG  . PHE A 1 184 ? -25.119 -8.328  -21.276 1.00 49.67  ? 184 PHE A CG  1 
ATOM   975  C CD1 . PHE A 1 184 ? -25.200 -8.489  -22.649 1.00 55.39  ? 184 PHE A CD1 1 
ATOM   976  C CD2 . PHE A 1 184 ? -23.869 -8.095  -20.711 1.00 49.51  ? 184 PHE A CD2 1 
ATOM   977  C CE1 . PHE A 1 184 ? -24.053 -8.412  -23.436 1.00 60.36  ? 184 PHE A CE1 1 
ATOM   978  C CE2 . PHE A 1 184 ? -22.727 -8.015  -21.491 1.00 47.70  ? 184 PHE A CE2 1 
ATOM   979  C CZ  . PHE A 1 184 ? -22.816 -8.172  -22.847 1.00 54.60  ? 184 PHE A CZ  1 
ATOM   980  N N   . ALA A 1 185 ? -29.252 -6.465  -19.641 1.00 44.00  ? 185 ALA A N   1 
ATOM   981  C CA  . ALA A 1 185 ? -30.326 -6.312  -18.667 1.00 43.65  ? 185 ALA A CA  1 
ATOM   982  C C   . ALA A 1 185 ? -31.540 -5.602  -19.240 1.00 54.06  ? 185 ALA A C   1 
ATOM   983  O O   . ALA A 1 185 ? -32.399 -5.165  -18.464 1.00 60.86  ? 185 ALA A O   1 
ATOM   984  C CB  . ALA A 1 185 ? -29.851 -5.540  -17.433 1.00 35.91  ? 185 ALA A CB  1 
ATOM   985  N N   . ILE A 1 186 ? -31.625 -5.464  -20.566 1.00 54.06  ? 186 ILE A N   1 
ATOM   986  C CA  . ILE A 1 186 ? -32.704 -4.698  -21.181 1.00 59.80  ? 186 ILE A CA  1 
ATOM   987  C C   . ILE A 1 186 ? -34.061 -5.230  -20.722 1.00 59.30  ? 186 ILE A C   1 
ATOM   988  O O   . ILE A 1 186 ? -34.277 -6.445  -20.624 1.00 55.55  ? 186 ILE A O   1 
ATOM   989  C CB  . ILE A 1 186 ? -32.566 -4.730  -22.716 1.00 59.66  ? 186 ILE A CB  1 
ATOM   990  C CG1 . ILE A 1 186 ? -32.973 -6.093  -23.252 1.00 61.87  ? 186 ILE A CG1 1 
ATOM   991  C CG2 . ILE A 1 186 ? -31.148 -4.400  -23.177 1.00 50.82  ? 186 ILE A CG2 1 
ATOM   992  C CD1 . ILE A 1 186 ? -33.177 -6.088  -24.708 1.00 72.68  ? 186 ILE A CD1 1 
ATOM   993  N N   . SER A 1 187 ? -34.976 -4.302  -20.425 1.00 59.88  ? 187 SER A N   1 
ATOM   994  C CA  . SER A 1 187 ? -36.258 -4.658  -19.823 1.00 55.50  ? 187 SER A CA  1 
ATOM   995  C C   . SER A 1 187 ? -37.056 -5.543  -20.762 1.00 55.69  ? 187 SER A C   1 
ATOM   996  O O   . SER A 1 187 ? -37.172 -5.256  -21.955 1.00 56.62  ? 187 SER A O   1 
ATOM   997  C CB  . SER A 1 187 ? -37.056 -3.400  -19.472 1.00 50.40  ? 187 SER A CB  1 
ATOM   998  O OG  . SER A 1 187 ? -38.150 -3.717  -18.626 1.00 47.95  ? 187 SER A OG  1 
ATOM   999  N N   . GLY A 1 188 ? -37.591 -6.638  -20.217 1.00 57.65  ? 188 GLY A N   1 
ATOM   1000 C CA  . GLY A 1 188 ? -38.345 -7.619  -20.966 1.00 60.52  ? 188 GLY A CA  1 
ATOM   1001 C C   . GLY A 1 188 ? -37.596 -8.914  -21.229 1.00 61.91  ? 188 GLY A C   1 
ATOM   1002 O O   . GLY A 1 188 ? -38.232 -9.962  -21.394 1.00 68.04  ? 188 GLY A O   1 
ATOM   1003 N N   . TYR A 1 189 ? -36.267 -8.872  -21.276 1.00 61.59  ? 189 TYR A N   1 
ATOM   1004 C CA  . TYR A 1 189 ? -35.501 -10.070 -21.607 1.00 62.97  ? 189 TYR A CA  1 
ATOM   1005 C C   . TYR A 1 189 ? -34.430 -10.379 -20.557 1.00 60.89  ? 189 TYR A C   1 
ATOM   1006 O O   . TYR A 1 189 ? -33.470 -11.111 -20.844 1.00 55.51  ? 189 TYR A O   1 
ATOM   1007 C CB  . TYR A 1 189 ? -34.904 -9.918  -23.012 1.00 64.20  ? 189 TYR A CB  1 
ATOM   1008 C CG  . TYR A 1 189 ? -35.967 -9.523  -24.028 1.00 74.07  ? 189 TYR A CG  1 
ATOM   1009 C CD1 . TYR A 1 189 ? -37.128 -10.285 -24.175 1.00 76.86  ? 189 TYR A CD1 1 
ATOM   1010 C CD2 . TYR A 1 189 ? -35.834 -8.368  -24.813 1.00 75.60  ? 189 TYR A CD2 1 
ATOM   1011 C CE1 . TYR A 1 189 ? -38.131 -9.919  -25.078 1.00 84.54  ? 189 TYR A CE1 1 
ATOM   1012 C CE2 . TYR A 1 189 ? -36.829 -7.992  -25.733 1.00 81.91  ? 189 TYR A CE2 1 
ATOM   1013 C CZ  . TYR A 1 189 ? -37.980 -8.773  -25.855 1.00 88.29  ? 189 TYR A CZ  1 
ATOM   1014 O OH  . TYR A 1 189 ? -38.980 -8.428  -26.749 1.00 79.67  ? 189 TYR A OH  1 
ATOM   1015 N N   . GLU A 1 190 ? -34.598 -9.867  -19.329 1.00 54.37  ? 190 GLU A N   1 
ATOM   1016 C CA  . GLU A 1 190 ? -33.553 -10.006 -18.321 1.00 49.83  ? 190 GLU A CA  1 
ATOM   1017 C C   . GLU A 1 190 ? -33.240 -11.460 -18.001 1.00 48.47  ? 190 GLU A C   1 
ATOM   1018 O O   . GLU A 1 190 ? -32.081 -11.792 -17.738 1.00 49.85  ? 190 GLU A O   1 
ATOM   1019 C CB  . GLU A 1 190 ? -33.941 -9.252  -17.057 1.00 52.17  ? 190 GLU A CB  1 
ATOM   1020 C CG  . GLU A 1 190 ? -33.995 -7.741  -17.253 1.00 54.53  ? 190 GLU A CG  1 
ATOM   1021 C CD  . GLU A 1 190 ? -35.395 -7.215  -17.457 1.00 56.97  ? 190 GLU A CD  1 
ATOM   1022 O OE1 . GLU A 1 190 ? -36.187 -7.915  -18.136 1.00 57.74  ? 190 GLU A OE1 1 
ATOM   1023 O OE2 . GLU A 1 190 ? -35.687 -6.102  -16.938 1.00 52.65  ? 190 GLU A OE2 1 
ATOM   1024 N N   . VAL A 1 191 ? -34.249 -12.332 -18.027 1.00 52.23  ? 191 VAL A N   1 
ATOM   1025 C CA  . VAL A 1 191 ? -34.043 -13.742 -17.709 1.00 43.83  ? 191 VAL A CA  1 
ATOM   1026 C C   . VAL A 1 191 ? -33.272 -14.432 -18.820 1.00 51.49  ? 191 VAL A C   1 
ATOM   1027 O O   . VAL A 1 191 ? -32.323 -15.184 -18.573 1.00 54.69  ? 191 VAL A O   1 
ATOM   1028 C CB  . VAL A 1 191 ? -35.395 -14.439 -17.467 1.00 45.65  ? 191 VAL A CB  1 
ATOM   1029 C CG1 . VAL A 1 191 ? -35.202 -15.936 -17.332 1.00 43.31  ? 191 VAL A CG1 1 
ATOM   1030 C CG2 . VAL A 1 191 ? -36.111 -13.845 -16.247 1.00 44.78  ? 191 VAL A CG2 1 
ATOM   1031 N N   . LEU A 1 192 ? -33.681 -14.202 -20.062 1.00 52.71  ? 192 LEU A N   1 
ATOM   1032 C CA  . LEU A 1 192 ? -33.076 -14.916 -21.178 1.00 54.45  ? 192 LEU A CA  1 
ATOM   1033 C C   . LEU A 1 192 ? -31.593 -14.579 -21.287 1.00 57.81  ? 192 LEU A C   1 
ATOM   1034 O O   . LEU A 1 192 ? -30.755 -15.448 -21.578 1.00 56.93  ? 192 LEU A O   1 
ATOM   1035 C CB  . LEU A 1 192 ? -33.844 -14.556 -22.447 1.00 62.30  ? 192 LEU A CB  1 
ATOM   1036 C CG  . LEU A 1 192 ? -35.379 -14.682 -22.300 1.00 67.18  ? 192 LEU A CG  1 
ATOM   1037 C CD1 . LEU A 1 192 ? -36.151 -14.318 -23.559 1.00 66.60  ? 192 LEU A CD1 1 
ATOM   1038 C CD2 . LEU A 1 192 ? -35.791 -16.077 -21.826 1.00 68.27  ? 192 LEU A CD2 1 
ATOM   1039 N N   . PHE A 1 193 ? -31.247 -13.330 -20.988 1.00 55.60  ? 193 PHE A N   1 
ATOM   1040 C CA  . PHE A 1 193 ? -29.874 -12.856 -20.951 1.00 48.23  ? 193 PHE A CA  1 
ATOM   1041 C C   . PHE A 1 193 ? -29.088 -13.305 -19.724 1.00 44.51  ? 193 PHE A C   1 
ATOM   1042 O O   . PHE A 1 193 ? -27.888 -13.027 -19.656 1.00 44.53  ? 193 PHE A O   1 
ATOM   1043 C CB  . PHE A 1 193 ? -29.872 -11.338 -21.000 1.00 44.41  ? 193 PHE A CB  1 
ATOM   1044 C CG  . PHE A 1 193 ? -30.136 -10.786 -22.343 1.00 49.03  ? 193 PHE A CG  1 
ATOM   1045 C CD1 . PHE A 1 193 ? -29.398 -11.207 -23.425 1.00 57.27  ? 193 PHE A CD1 1 
ATOM   1046 C CD2 . PHE A 1 193 ? -31.098 -9.813  -22.534 1.00 61.63  ? 193 PHE A CD2 1 
ATOM   1047 C CE1 . PHE A 1 193 ? -29.626 -10.680 -24.682 1.00 66.81  ? 193 PHE A CE1 1 
ATOM   1048 C CE2 . PHE A 1 193 ? -31.334 -9.273  -23.799 1.00 63.25  ? 193 PHE A CE2 1 
ATOM   1049 C CZ  . PHE A 1 193 ? -30.601 -9.707  -24.867 1.00 65.52  ? 193 PHE A CZ  1 
ATOM   1050 N N   . LEU A 1 194 ? -29.713 -13.985 -18.763 1.00 41.39  ? 194 LEU A N   1 
ATOM   1051 C CA  . LEU A 1 194 ? -29.105 -14.120 -17.445 1.00 39.85  ? 194 LEU A CA  1 
ATOM   1052 C C   . LEU A 1 194 ? -27.684 -14.684 -17.507 1.00 41.15  ? 194 LEU A C   1 
ATOM   1053 O O   . LEU A 1 194 ? -26.756 -14.124 -16.912 1.00 39.17  ? 194 LEU A O   1 
ATOM   1054 C CB  . LEU A 1 194 ? -29.984 -14.980 -16.553 1.00 35.88  ? 194 LEU A CB  1 
ATOM   1055 C CG  . LEU A 1 194 ? -29.692 -14.644 -15.106 1.00 34.98  ? 194 LEU A CG  1 
ATOM   1056 C CD1 . LEU A 1 194 ? -30.195 -13.247 -14.867 1.00 41.72  ? 194 LEU A CD1 1 
ATOM   1057 C CD2 . LEU A 1 194 ? -30.341 -15.608 -14.157 1.00 36.93  ? 194 LEU A CD2 1 
ATOM   1058 N N   . THR A 1 195 ? -27.491 -15.791 -18.222 1.00 41.69  ? 195 THR A N   1 
ATOM   1059 C CA  . THR A 1 195 ? -26.158 -16.383 -18.288 1.00 45.78  ? 195 THR A CA  1 
ATOM   1060 C C   . THR A 1 195 ? -25.164 -15.437 -18.950 1.00 46.42  ? 195 THR A C   1 
ATOM   1061 O O   . THR A 1 195 ? -24.005 -15.331 -18.526 1.00 45.42  ? 195 THR A O   1 
ATOM   1062 C CB  . THR A 1 195 ? -26.219 -17.690 -19.056 1.00 46.39  ? 195 THR A CB  1 
ATOM   1063 O OG1 . THR A 1 195 ? -27.085 -17.488 -20.177 1.00 60.44  ? 195 THR A OG1 1 
ATOM   1064 C CG2 . THR A 1 195 ? -26.764 -18.794 -18.193 1.00 42.98  ? 195 THR A CG2 1 
ATOM   1065 N N   . THR A 1 196 ? -25.586 -14.769 -20.014 1.00 44.18  ? 196 THR A N   1 
ATOM   1066 C CA  . THR A 1 196 ? -24.718 -13.786 -20.635 1.00 45.96  ? 196 THR A CA  1 
ATOM   1067 C C   . THR A 1 196 ? -24.341 -12.707 -19.636 1.00 45.87  ? 196 THR A C   1 
ATOM   1068 O O   . THR A 1 196 ? -23.156 -12.403 -19.451 1.00 45.99  ? 196 THR A O   1 
ATOM   1069 C CB  . THR A 1 196 ? -25.411 -13.205 -21.865 1.00 53.40  ? 196 THR A CB  1 
ATOM   1070 O OG1 . THR A 1 196 ? -25.910 -14.280 -22.671 1.00 64.59  ? 196 THR A OG1 1 
ATOM   1071 C CG2 . THR A 1 196 ? -24.470 -12.400 -22.668 1.00 51.99  ? 196 THR A CG2 1 
ATOM   1072 N N   . TYR A 1 197 ? -25.343 -12.143 -18.952 1.00 45.60  ? 197 TYR A N   1 
ATOM   1073 C CA  . TYR A 1 197 ? -25.085 -11.194 -17.869 1.00 39.66  ? 197 TYR A CA  1 
ATOM   1074 C C   . TYR A 1 197 ? -24.125 -11.763 -16.830 1.00 41.46  ? 197 TYR A C   1 
ATOM   1075 O O   . TYR A 1 197 ? -23.221 -11.060 -16.369 1.00 47.08  ? 197 TYR A O   1 
ATOM   1076 C CB  . TYR A 1 197 ? -26.391 -10.800 -17.187 1.00 43.51  ? 197 TYR A CB  1 
ATOM   1077 C CG  . TYR A 1 197 ? -26.253 -9.692  -16.159 1.00 41.62  ? 197 TYR A CG  1 
ATOM   1078 C CD1 . TYR A 1 197 ? -25.705 -9.949  -14.901 1.00 39.17  ? 197 TYR A CD1 1 
ATOM   1079 C CD2 . TYR A 1 197 ? -26.739 -8.418  -16.416 1.00 34.46  ? 197 TYR A CD2 1 
ATOM   1080 C CE1 . TYR A 1 197 ? -25.583 -8.952  -13.956 1.00 38.72  ? 197 TYR A CE1 1 
ATOM   1081 C CE2 . TYR A 1 197 ? -26.644 -7.413  -15.482 1.00 36.00  ? 197 TYR A CE2 1 
ATOM   1082 C CZ  . TYR A 1 197 ? -26.068 -7.668  -14.240 1.00 42.33  ? 197 TYR A CZ  1 
ATOM   1083 O OH  . TYR A 1 197 ? -25.962 -6.641  -13.289 1.00 32.27  ? 197 TYR A OH  1 
ATOM   1084 N N   . ALA A 1 198 ? -24.316 -13.019 -16.422 1.00 39.23  ? 198 ALA A N   1 
ATOM   1085 C CA  . ALA A 1 198 ? -23.438 -13.582 -15.402 1.00 34.51  ? 198 ALA A CA  1 
ATOM   1086 C C   . ALA A 1 198 ? -22.002 -13.660 -15.894 1.00 32.16  ? 198 ALA A C   1 
ATOM   1087 O O   . ALA A 1 198 ? -21.106 -13.057 -15.309 1.00 38.72  ? 198 ALA A O   1 
ATOM   1088 C CB  . ALA A 1 198 ? -23.931 -14.959 -14.976 1.00 39.28  ? 198 ALA A CB  1 
ATOM   1089 N N   . GLN A 1 199 ? -21.765 -14.391 -16.982 1.00 39.15  ? 199 GLN A N   1 
ATOM   1090 C CA  . GLN A 1 199 ? -20.398 -14.605 -17.452 1.00 41.24  ? 199 GLN A CA  1 
ATOM   1091 C C   . GLN A 1 199 ? -19.675 -13.283 -17.691 1.00 41.07  ? 199 GLN A C   1 
ATOM   1092 O O   . GLN A 1 199 ? -18.473 -13.175 -17.431 1.00 37.63  ? 199 GLN A O   1 
ATOM   1093 C CB  . GLN A 1 199 ? -20.420 -15.434 -18.728 1.00 40.20  ? 199 GLN A CB  1 
ATOM   1094 C CG  . GLN A 1 199 ? -20.964 -16.836 -18.548 1.00 47.23  ? 199 GLN A CG  1 
ATOM   1095 C CD  . GLN A 1 199 ? -20.045 -17.732 -17.734 1.00 56.97  ? 199 GLN A CD  1 
ATOM   1096 O OE1 . GLN A 1 199 ? -18.820 -17.533 -17.703 1.00 63.53  ? 199 GLN A OE1 1 
ATOM   1097 N NE2 . GLN A 1 199 ? -20.629 -18.738 -17.079 1.00 48.81  ? 199 GLN A NE2 1 
ATOM   1098 N N   . ALA A 1 200 ? -20.394 -12.271 -18.178 1.00 36.54  ? 200 ALA A N   1 
ATOM   1099 C CA  . ALA A 1 200 ? -19.818 -10.946 -18.355 1.00 38.20  ? 200 ALA A CA  1 
ATOM   1100 C C   . ALA A 1 200 ? -19.440 -10.316 -17.012 1.00 39.23  ? 200 ALA A C   1 
ATOM   1101 O O   . ALA A 1 200 ? -18.272 -9.978  -16.770 1.00 36.88  ? 200 ALA A O   1 
ATOM   1102 C CB  . ALA A 1 200 ? -20.812 -10.064 -19.100 1.00 38.96  ? 200 ALA A CB  1 
ATOM   1103 N N   . ALA A 1 201 ? -20.429 -10.120 -16.139 1.00 37.63  ? 201 ALA A N   1 
ATOM   1104 C CA  . ALA A 1 201 ? -20.216 -9.618  -14.786 1.00 32.21  ? 201 ALA A CA  1 
ATOM   1105 C C   . ALA A 1 201 ? -19.004 -10.267 -14.143 1.00 31.32  ? 201 ALA A C   1 
ATOM   1106 O O   . ALA A 1 201 ? -18.189 -9.598  -13.504 1.00 29.27  ? 201 ALA A O   1 
ATOM   1107 C CB  . ALA A 1 201 ? -21.447 -9.873  -13.927 1.00 27.49  ? 201 ALA A CB  1 
ATOM   1108 N N   . ASN A 1 202 ? -18.863 -11.570 -14.338 1.00 31.74  ? 202 ASN A N   1 
ATOM   1109 C CA  . ASN A 1 202 ? -17.753 -12.276 -13.726 1.00 33.38  ? 202 ASN A CA  1 
ATOM   1110 C C   . ASN A 1 202 ? -16.420 -11.891 -14.366 1.00 33.51  ? 202 ASN A C   1 
ATOM   1111 O O   . ASN A 1 202 ? -15.400 -11.782 -13.680 1.00 31.16  ? 202 ASN A O   1 
ATOM   1112 C CB  . ASN A 1 202 ? -17.986 -13.773 -13.813 1.00 31.81  ? 202 ASN A CB  1 
ATOM   1113 C CG  . ASN A 1 202 ? -16.798 -14.550 -13.339 1.00 35.02  ? 202 ASN A CG  1 
ATOM   1114 O OD1 . ASN A 1 202 ? -16.409 -14.462 -12.170 1.00 34.91  ? 202 ASN A OD1 1 
ATOM   1115 N ND2 . ASN A 1 202 ? -16.190 -15.305 -14.246 1.00 35.57  ? 202 ASN A ND2 1 
ATOM   1116 N N   . THR A 1 203 ? -16.399 -11.686 -15.677 1.00 37.37  ? 203 THR A N   1 
ATOM   1117 C CA  . THR A 1 203 ? -15.174 -11.182 -16.278 1.00 35.31  ? 203 THR A CA  1 
ATOM   1118 C C   . THR A 1 203 ? -14.899 -9.758  -15.814 1.00 31.22  ? 203 THR A C   1 
ATOM   1119 O O   . THR A 1 203 ? -13.744 -9.397  -15.587 1.00 29.34  ? 203 THR A O   1 
ATOM   1120 C CB  . THR A 1 203 ? -15.251 -11.266 -17.809 1.00 37.22  ? 203 THR A CB  1 
ATOM   1121 O OG1 . THR A 1 203 ? -15.820 -12.520 -18.179 1.00 38.61  ? 203 THR A OG1 1 
ATOM   1122 C CG2 . THR A 1 203 ? -13.879 -11.196 -18.430 1.00 38.74  ? 203 THR A CG2 1 
ATOM   1123 N N   . HIS A 1 204 ? -15.940 -8.951  -15.612 1.00 32.83  ? 204 HIS A N   1 
ATOM   1124 C CA  . HIS A 1 204 ? -15.710 -7.564  -15.208 1.00 32.05  ? 204 HIS A CA  1 
ATOM   1125 C C   . HIS A 1 204 ? -15.098 -7.477  -13.805 1.00 30.75  ? 204 HIS A C   1 
ATOM   1126 O O   . HIS A 1 204 ? -14.069 -6.816  -13.604 1.00 31.30  ? 204 HIS A O   1 
ATOM   1127 C CB  . HIS A 1 204 ? -17.005 -6.771  -15.290 1.00 30.73  ? 204 HIS A CB  1 
ATOM   1128 C CG  . HIS A 1 204 ? -16.815 -5.311  -15.072 1.00 30.66  ? 204 HIS A CG  1 
ATOM   1129 N ND1 . HIS A 1 204 ? -17.866 -4.449  -14.844 1.00 31.65  ? 204 HIS A ND1 1 
ATOM   1130 C CD2 . HIS A 1 204 ? -15.689 -4.561  -15.019 1.00 28.72  ? 204 HIS A CD2 1 
ATOM   1131 C CE1 . HIS A 1 204 ? -17.395 -3.224  -14.693 1.00 31.00  ? 204 HIS A CE1 1 
ATOM   1132 N NE2 . HIS A 1 204 ? -16.076 -3.266  -14.785 1.00 28.80  ? 204 HIS A NE2 1 
ATOM   1133 N N   . LEU A 1 205 ? -15.695 -8.149  -12.823 1.00 28.59  ? 205 LEU A N   1 
ATOM   1134 C CA  . LEU A 1 205 ? -15.083 -8.173  -11.501 1.00 24.50  ? 205 LEU A CA  1 
ATOM   1135 C C   . LEU A 1 205 ? -13.660 -8.715  -11.563 1.00 26.44  ? 205 LEU A C   1 
ATOM   1136 O O   . LEU A 1 205 ? -12.707 -8.025  -11.194 1.00 26.42  ? 205 LEU A O   1 
ATOM   1137 C CB  . LEU A 1 205 ? -15.939 -8.991  -10.552 1.00 21.58  ? 205 LEU A CB  1 
ATOM   1138 C CG  . LEU A 1 205 ? -17.328 -8.383  -10.485 1.00 21.63  ? 205 LEU A CG  1 
ATOM   1139 C CD1 . LEU A 1 205 ? -18.220 -9.165  -9.573  1.00 24.41  ? 205 LEU A CD1 1 
ATOM   1140 C CD2 . LEU A 1 205 ? -17.225 -7.006  -9.995  1.00 21.28  ? 205 LEU A CD2 1 
ATOM   1141 N N   . PHE A 1 206 ? -13.496 -9.953  -12.044 1.00 33.88  ? 206 PHE A N   1 
ATOM   1142 C CA  . PHE A 1 206 ? -12.167 -10.559 -12.125 1.00 32.89  ? 206 PHE A CA  1 
ATOM   1143 C C   . PHE A 1 206 ? -11.168 -9.647  -12.814 1.00 32.03  ? 206 PHE A C   1 
ATOM   1144 O O   . PHE A 1 206 ? -9.963  -9.716  -12.542 1.00 32.77  ? 206 PHE A O   1 
ATOM   1145 C CB  . PHE A 1 206 ? -12.230 -11.877 -12.872 1.00 32.36  ? 206 PHE A CB  1 
ATOM   1146 C CG  . PHE A 1 206 ? -11.085 -12.765 -12.582 1.00 40.82  ? 206 PHE A CG  1 
ATOM   1147 C CD1 . PHE A 1 206 ? -11.017 -13.457 -11.384 1.00 44.95  ? 206 PHE A CD1 1 
ATOM   1148 C CD2 . PHE A 1 206 ? -10.048 -12.891 -13.490 1.00 41.51  ? 206 PHE A CD2 1 
ATOM   1149 C CE1 . PHE A 1 206 ? -9.939  -14.281 -11.103 1.00 44.16  ? 206 PHE A CE1 1 
ATOM   1150 C CE2 . PHE A 1 206 ? -8.966  -13.702 -13.216 1.00 44.68  ? 206 PHE A CE2 1 
ATOM   1151 C CZ  . PHE A 1 206 ? -8.914  -14.398 -12.021 1.00 47.39  ? 206 PHE A CZ  1 
ATOM   1152 N N   . LEU A 1 207 ? -11.649 -8.805  -13.721 1.00 30.24  ? 207 LEU A N   1 
ATOM   1153 C CA  . LEU A 1 207 ? -10.803 -7.797  -14.329 1.00 28.53  ? 207 LEU A CA  1 
ATOM   1154 C C   . LEU A 1 207 ? -10.465 -6.713  -13.317 1.00 32.60  ? 207 LEU A C   1 
ATOM   1155 O O   . LEU A 1 207 ? -9.285  -6.400  -13.096 1.00 34.77  ? 207 LEU A O   1 
ATOM   1156 C CB  . LEU A 1 207 ? -11.531 -7.215  -15.526 1.00 28.37  ? 207 LEU A CB  1 
ATOM   1157 C CG  . LEU A 1 207 ? -10.740 -6.542  -16.617 1.00 32.59  ? 207 LEU A CG  1 
ATOM   1158 C CD1 . LEU A 1 207 ? -11.707 -6.246  -17.713 1.00 37.89  ? 207 LEU A CD1 1 
ATOM   1159 C CD2 . LEU A 1 207 ? -10.167 -5.278  -16.132 1.00 37.09  ? 207 LEU A CD2 1 
ATOM   1160 N N   . LEU A 1 208 ? -11.501 -6.150  -12.674 1.00 27.99  ? 208 LEU A N   1 
ATOM   1161 C CA  . LEU A 1 208 ? -11.328 -5.043  -11.734 1.00 22.65  ? 208 LEU A CA  1 
ATOM   1162 C C   . LEU A 1 208 ? -10.328 -5.348  -10.631 1.00 27.72  ? 208 LEU A C   1 
ATOM   1163 O O   . LEU A 1 208 ? -9.574  -4.467  -10.217 1.00 33.64  ? 208 LEU A O   1 
ATOM   1164 C CB  . LEU A 1 208 ? -12.661 -4.676  -11.103 1.00 19.41  ? 208 LEU A CB  1 
ATOM   1165 C CG  . LEU A 1 208 ? -13.376 -3.502  -11.741 1.00 19.02  ? 208 LEU A CG  1 
ATOM   1166 C CD1 . LEU A 1 208 ? -14.727 -3.354  -11.147 1.00 20.05  ? 208 LEU A CD1 1 
ATOM   1167 C CD2 . LEU A 1 208 ? -12.568 -2.216  -11.620 1.00 17.71  ? 208 LEU A CD2 1 
ATOM   1168 N N   . LYS A 1 209 ? -10.320 -6.565  -10.097 1.00 26.78  ? 209 LYS A N   1 
ATOM   1169 C CA  . LYS A 1 209 ? -9.381  -6.791  -9.015  1.00 25.88  ? 209 LYS A CA  1 
ATOM   1170 C C   . LYS A 1 209 ? -7.953  -6.549  -9.464  1.00 31.42  ? 209 LYS A C   1 
ATOM   1171 O O   . LYS A 1 209 ? -7.114  -6.199  -8.631  1.00 37.08  ? 209 LYS A O   1 
ATOM   1172 C CB  . LYS A 1 209 ? -9.503  -8.192  -8.431  1.00 25.98  ? 209 LYS A CB  1 
ATOM   1173 C CG  . LYS A 1 209 ? -9.143  -9.294  -9.398  1.00 31.58  ? 209 LYS A CG  1 
ATOM   1174 C CD  . LYS A 1 209 ? -8.547  -10.517 -8.703  1.00 31.13  ? 209 LYS A CD  1 
ATOM   1175 C CE  . LYS A 1 209 ? -8.216  -11.561 -9.721  1.00 34.21  ? 209 LYS A CE  1 
ATOM   1176 N NZ  . LYS A 1 209 ? -7.604  -10.966 -10.935 1.00 34.29  ? 209 LYS A NZ  1 
ATOM   1177 N N   . ASP A 1 210 ? -7.645  -6.695  -10.763 1.00 29.99  ? 210 ASP A N   1 
ATOM   1178 C CA  . ASP A 1 210 ? -6.244  -6.550  -11.157 1.00 30.64  ? 210 ASP A CA  1 
ATOM   1179 C C   . ASP A 1 210 ? -5.719  -5.158  -10.841 1.00 28.57  ? 210 ASP A C   1 
ATOM   1180 O O   . ASP A 1 210 ? -4.544  -5.008  -10.486 1.00 27.01  ? 210 ASP A O   1 
ATOM   1181 C CB  . ASP A 1 210 ? -6.047  -6.909  -12.630 1.00 31.22  ? 210 ASP A CB  1 
ATOM   1182 C CG  . ASP A 1 210 ? -6.027  -8.413  -12.853 1.00 39.58  ? 210 ASP A CG  1 
ATOM   1183 O OD1 . ASP A 1 210 ? -6.279  -9.132  -11.861 1.00 37.59  ? 210 ASP A OD1 1 
ATOM   1184 O OD2 . ASP A 1 210 ? -5.748  -8.885  -13.987 1.00 42.42  ? 210 ASP A OD2 1 
ATOM   1185 N N   . ALA A 1 211 ? -6.591  -4.150  -10.905 1.00 23.98  ? 211 ALA A N   1 
ATOM   1186 C CA  . ALA A 1 211 ? -6.217  -2.808  -10.498 1.00 22.33  ? 211 ALA A CA  1 
ATOM   1187 C C   . ALA A 1 211 ? -5.656  -2.784  -9.080  1.00 31.12  ? 211 ALA A C   1 
ATOM   1188 O O   . ALA A 1 211 ? -4.660  -2.095  -8.824  1.00 31.27  ? 211 ALA A O   1 
ATOM   1189 C CB  . ALA A 1 211 ? -7.414  -1.869  -10.612 1.00 23.13  ? 211 ALA A CB  1 
ATOM   1190 N N   . GLN A 1 212 ? -6.269  -3.522  -8.134  1.00 29.69  ? 212 GLN A N   1 
ATOM   1191 C CA  . GLN A 1 212 ? -5.682  -3.584  -6.789  1.00 29.51  ? 212 GLN A CA  1 
ATOM   1192 C C   . GLN A 1 212 ? -4.288  -4.214  -6.810  1.00 30.31  ? 212 GLN A C   1 
ATOM   1193 O O   . GLN A 1 212 ? -3.339  -3.669  -6.232  1.00 32.94  ? 212 GLN A O   1 
ATOM   1194 C CB  . GLN A 1 212 ? -6.587  -4.332  -5.803  1.00 25.60  ? 212 GLN A CB  1 
ATOM   1195 C CG  . GLN A 1 212 ? -8.000  -3.768  -5.631  1.00 27.51  ? 212 GLN A CG  1 
ATOM   1196 C CD  . GLN A 1 212 ? -8.063  -2.242  -5.653  1.00 24.00  ? 212 GLN A CD  1 
ATOM   1197 O OE1 . GLN A 1 212 ? -7.581  -1.575  -4.755  1.00 24.50  ? 212 GLN A OE1 1 
ATOM   1198 N NE2 . GLN A 1 212 ? -8.667  -1.698  -6.684  1.00 27.23  ? 212 GLN A NE2 1 
ATOM   1199 N N   . ILE A 1 213 ? -4.131  -5.331  -7.508  1.00 29.12  ? 213 ILE A N   1 
ATOM   1200 C CA  . ILE A 1 213 ? -2.853  -6.035  -7.502  1.00 35.38  ? 213 ILE A CA  1 
ATOM   1201 C C   . ILE A 1 213 ? -1.748  -5.168  -8.100  1.00 38.71  ? 213 ILE A C   1 
ATOM   1202 O O   . ILE A 1 213 ? -0.745  -4.861  -7.448  1.00 40.65  ? 213 ILE A O   1 
ATOM   1203 C CB  . ILE A 1 213 ? -2.993  -7.365  -8.251  1.00 36.08  ? 213 ILE A CB  1 
ATOM   1204 C CG1 . ILE A 1 213 ? -3.932  -8.279  -7.463  1.00 38.36  ? 213 ILE A CG1 1 
ATOM   1205 C CG2 . ILE A 1 213 ? -1.654  -7.998  -8.416  1.00 34.42  ? 213 ILE A CG2 1 
ATOM   1206 C CD1 . ILE A 1 213 ? -4.600  -9.300  -8.299  1.00 38.07  ? 213 ILE A CD1 1 
ATOM   1207 N N   . TYR A 1 214 ? -1.916  -4.755  -9.349  1.00 36.54  ? 214 TYR A N   1 
ATOM   1208 C CA  . TYR A 1 214 ? -0.824  -4.130  -10.085 1.00 39.26  ? 214 TYR A CA  1 
ATOM   1209 C C   . TYR A 1 214 ? -0.917  -2.600  -10.189 1.00 35.61  ? 214 TYR A C   1 
ATOM   1210 O O   . TYR A 1 214 ? 0.024   -1.971  -10.669 1.00 35.14  ? 214 TYR A O   1 
ATOM   1211 C CB  . TYR A 1 214 ? -0.751  -4.743  -11.490 1.00 39.33  ? 214 TYR A CB  1 
ATOM   1212 C CG  . TYR A 1 214 ? -0.690  -6.258  -11.565 1.00 40.31  ? 214 TYR A CG  1 
ATOM   1213 C CD1 . TYR A 1 214 ? 0.507   -6.935  -11.476 1.00 42.93  ? 214 TYR A CD1 1 
ATOM   1214 C CD2 . TYR A 1 214 ? -1.837  -7.008  -11.757 1.00 40.93  ? 214 TYR A CD2 1 
ATOM   1215 C CE1 . TYR A 1 214 ? 0.553   -8.318  -11.570 1.00 39.82  ? 214 TYR A CE1 1 
ATOM   1216 C CE2 . TYR A 1 214 ? -1.792  -8.385  -11.847 1.00 34.67  ? 214 TYR A CE2 1 
ATOM   1217 C CZ  . TYR A 1 214 ? -0.603  -9.029  -11.749 1.00 35.82  ? 214 TYR A CZ  1 
ATOM   1218 O OH  . TYR A 1 214 ? -0.559  -10.397 -11.828 1.00 47.97  ? 214 TYR A OH  1 
ATOM   1219 N N   . GLY A 1 215 ? -2.022  -1.991  -9.782  1.00 34.72  ? 215 GLY A N   1 
ATOM   1220 C CA  . GLY A 1 215 ? -2.152  -0.541  -9.718  1.00 35.10  ? 215 GLY A CA  1 
ATOM   1221 C C   . GLY A 1 215 ? -0.912  0.309   -9.481  1.00 35.93  ? 215 GLY A C   1 
ATOM   1222 O O   . GLY A 1 215 ? -0.609  1.154   -10.317 1.00 39.13  ? 215 GLY A O   1 
ATOM   1223 N N   . GLU A 1 216 ? -0.189  0.113   -8.371  1.00 42.63  ? 216 GLU A N   1 
ATOM   1224 C CA  . GLU A 1 216 ? 1.078   0.818   -8.154  1.00 43.47  ? 216 GLU A CA  1 
ATOM   1225 C C   . GLU A 1 216 ? 2.072   0.584   -9.287  1.00 39.31  ? 216 GLU A C   1 
ATOM   1226 O O   . GLU A 1 216 ? 2.635   1.538   -9.839  1.00 34.35  ? 216 GLU A O   1 
ATOM   1227 C CB  . GLU A 1 216 ? 1.712   0.385   -6.837  1.00 39.08  ? 216 GLU A CB  1 
ATOM   1228 C CG  . GLU A 1 216 ? 1.120   1.042   -5.648  1.00 49.57  ? 216 GLU A CG  1 
ATOM   1229 C CD  . GLU A 1 216 ? 2.038   0.921   -4.465  1.00 62.47  ? 216 GLU A CD  1 
ATOM   1230 O OE1 . GLU A 1 216 ? 2.867   -0.011  -4.494  1.00 69.38  ? 216 GLU A OE1 1 
ATOM   1231 O OE2 . GLU A 1 216 ? 1.935   1.739   -3.514  1.00 71.32  ? 216 GLU A OE2 1 
ATOM   1232 N N   . GLU A 1 217 ? 2.362   -0.688  -9.580  1.00 36.50  ? 217 GLU A N   1 
ATOM   1233 C CA  . GLU A 1 217 ? 3.331   -1.027  -10.616 1.00 35.68  ? 217 GLU A CA  1 
ATOM   1234 C C   . GLU A 1 217 ? 3.029   -0.282  -11.919 1.00 41.67  ? 217 GLU A C   1 
ATOM   1235 O O   . GLU A 1 217 ? 3.928   0.287   -12.552 1.00 40.62  ? 217 GLU A O   1 
ATOM   1236 C CB  . GLU A 1 217 ? 3.315   -2.539  -10.855 1.00 38.34  ? 217 GLU A CB  1 
ATOM   1237 C CG  . GLU A 1 217 ? 3.760   -3.431  -9.695  1.00 40.69  ? 217 GLU A CG  1 
ATOM   1238 C CD  . GLU A 1 217 ? 3.620   -4.938  -10.022 1.00 51.36  ? 217 GLU A CD  1 
ATOM   1239 O OE1 . GLU A 1 217 ? 3.511   -5.282  -11.219 1.00 56.97  ? 217 GLU A OE1 1 
ATOM   1240 O OE2 . GLU A 1 217 ? 3.583   -5.780  -9.090  1.00 48.15  ? 217 GLU A OE2 1 
ATOM   1241 N N   . TRP A 1 218 ? 1.758   -0.265  -12.331 1.00 39.89  ? 218 TRP A N   1 
ATOM   1242 C CA  . TRP A 1 218 ? 1.362   0.466   -13.530 1.00 40.96  ? 218 TRP A CA  1 
ATOM   1243 C C   . TRP A 1 218 ? 1.369   1.980   -13.346 1.00 41.13  ? 218 TRP A C   1 
ATOM   1244 O O   . TRP A 1 218 ? 1.212   2.702   -14.331 1.00 48.03  ? 218 TRP A O   1 
ATOM   1245 C CB  . TRP A 1 218 ? -0.031  0.044   -13.992 1.00 41.65  ? 218 TRP A CB  1 
ATOM   1246 C CG  . TRP A 1 218 ? -0.238  -1.440  -14.136 1.00 40.62  ? 218 TRP A CG  1 
ATOM   1247 C CD1 . TRP A 1 218 ? 0.720   -2.391  -14.291 1.00 41.53  ? 218 TRP A CD1 1 
ATOM   1248 C CD2 . TRP A 1 218 ? -1.495  -2.122  -14.198 1.00 33.95  ? 218 TRP A CD2 1 
ATOM   1249 N NE1 . TRP A 1 218 ? 0.138   -3.627  -14.415 1.00 41.18  ? 218 TRP A NE1 1 
ATOM   1250 C CE2 . TRP A 1 218 ? -1.221  -3.485  -14.366 1.00 35.26  ? 218 TRP A CE2 1 
ATOM   1251 C CE3 . TRP A 1 218 ? -2.825  -1.709  -14.116 1.00 35.83  ? 218 TRP A CE3 1 
ATOM   1252 C CZ2 . TRP A 1 218 ? -2.227  -4.447  -14.440 1.00 41.66  ? 218 TRP A CZ2 1 
ATOM   1253 C CZ3 . TRP A 1 218 ? -3.832  -2.671  -14.199 1.00 35.74  ? 218 TRP A CZ3 1 
ATOM   1254 C CH2 . TRP A 1 218 ? -3.526  -4.019  -14.357 1.00 39.29  ? 218 TRP A CH2 1 
ATOM   1255 N N   . GLY A 1 219 ? 1.510   2.478   -12.126 1.00 38.62  ? 219 GLY A N   1 
ATOM   1256 C CA  . GLY A 1 219 ? 1.642   3.898   -11.912 1.00 35.37  ? 219 GLY A CA  1 
ATOM   1257 C C   . GLY A 1 219 ? 0.363   4.646   -11.645 1.00 40.75  ? 219 GLY A C   1 
ATOM   1258 O O   . GLY A 1 219 ? 0.400   5.880   -11.558 1.00 49.77  ? 219 GLY A O   1 
ATOM   1259 N N   . TYR A 1 220 ? -0.769  3.954   -11.546 1.00 40.76  ? 220 TYR A N   1 
ATOM   1260 C CA  . TYR A 1 220 ? -2.001  4.577   -11.074 1.00 39.19  ? 220 TYR A CA  1 
ATOM   1261 C C   . TYR A 1 220 ? -1.787  5.192   -9.694  1.00 40.17  ? 220 TYR A C   1 
ATOM   1262 O O   . TYR A 1 220 ? -1.074  4.638   -8.851  1.00 36.42  ? 220 TYR A O   1 
ATOM   1263 C CB  . TYR A 1 220 ? -3.104  3.535   -10.980 1.00 38.24  ? 220 TYR A CB  1 
ATOM   1264 C CG  . TYR A 1 220 ? -3.871  3.237   -12.237 1.00 35.53  ? 220 TYR A CG  1 
ATOM   1265 C CD1 . TYR A 1 220 ? -4.600  4.208   -12.863 1.00 31.92  ? 220 TYR A CD1 1 
ATOM   1266 C CD2 . TYR A 1 220 ? -3.906  1.943   -12.760 1.00 37.39  ? 220 TYR A CD2 1 
ATOM   1267 C CE1 . TYR A 1 220 ? -5.335  3.919   -13.997 1.00 39.24  ? 220 TYR A CE1 1 
ATOM   1268 C CE2 . TYR A 1 220 ? -4.633  1.640   -13.902 1.00 36.81  ? 220 TYR A CE2 1 
ATOM   1269 C CZ  . TYR A 1 220 ? -5.348  2.641   -14.522 1.00 39.17  ? 220 TYR A CZ  1 
ATOM   1270 O OH  . TYR A 1 220 ? -6.090  2.379   -15.663 1.00 35.85  ? 220 TYR A OH  1 
ATOM   1271 N N   . GLU A 1 221 ? -2.429  6.326   -9.443  1.00 42.75  ? 221 GLU A N   1 
ATOM   1272 C CA  . GLU A 1 221 ? -2.238  6.956   -8.150  1.00 39.13  ? 221 GLU A CA  1 
ATOM   1273 C C   . GLU A 1 221 ? -3.144  6.294   -7.114  1.00 39.86  ? 221 GLU A C   1 
ATOM   1274 O O   . GLU A 1 221 ? -4.092  5.582   -7.456  1.00 40.25  ? 221 GLU A O   1 
ATOM   1275 C CB  . GLU A 1 221 ? -2.520  8.454   -8.239  1.00 41.98  ? 221 GLU A CB  1 
ATOM   1276 C CG  . GLU A 1 221 ? -2.010  9.140   -9.511  1.00 51.86  ? 221 GLU A CG  1 
ATOM   1277 C CD  . GLU A 1 221 ? -0.585  9.743   -9.392  1.00 57.28  ? 221 GLU A CD  1 
ATOM   1278 O OE1 . GLU A 1 221 ? 0.351   9.061   -8.870  1.00 42.63  ? 221 GLU A OE1 1 
ATOM   1279 O OE2 . GLU A 1 221 ? -0.424  10.920  -9.822  1.00 57.05  ? 221 GLU A OE2 1 
ATOM   1280 N N   . LYS A 1 222 ? -2.819  6.524   -5.836  1.00 36.01  ? 222 LYS A N   1 
ATOM   1281 C CA  . LYS A 1 222 ? -3.628  6.090   -4.701  1.00 30.36  ? 222 LYS A CA  1 
ATOM   1282 C C   . LYS A 1 222 ? -5.133  6.211   -4.988  1.00 32.34  ? 222 LYS A C   1 
ATOM   1283 O O   . LYS A 1 222 ? -5.874  5.232   -4.874  1.00 33.14  ? 222 LYS A O   1 
ATOM   1284 C CB  . LYS A 1 222 ? -3.251  6.939   -3.476  1.00 42.72  ? 222 LYS A CB  1 
ATOM   1285 C CG  . LYS A 1 222 ? -1.841  6.768   -2.870  1.00 44.62  ? 222 LYS A CG  1 
ATOM   1286 C CD  . LYS A 1 222 ? -1.671  5.595   -1.926  1.00 58.75  ? 222 LYS A CD  1 
ATOM   1287 C CE  . LYS A 1 222 ? -0.235  5.589   -1.298  1.00 72.15  ? 222 LYS A CE  1 
ATOM   1288 N NZ  . LYS A 1 222 ? 0.136   6.681   -0.337  1.00 63.72  ? 222 LYS A NZ  1 
ATOM   1289 N N   . GLU A 1 223 ? -5.594  7.419   -5.353  1.00 32.68  ? 223 GLU A N   1 
ATOM   1290 C CA  . GLU A 1 223 ? -7.003  7.678   -5.683  1.00 30.95  ? 223 GLU A CA  1 
ATOM   1291 C C   . GLU A 1 223 ? -7.523  6.748   -6.773  1.00 34.52  ? 223 GLU A C   1 
ATOM   1292 O O   . GLU A 1 223 ? -8.587  6.133   -6.629  1.00 37.43  ? 223 GLU A O   1 
ATOM   1293 C CB  . GLU A 1 223 ? -7.188  9.109   -6.198  1.00 38.28  ? 223 GLU A CB  1 
ATOM   1294 C CG  . GLU A 1 223 ? -6.509  10.238  -5.504  1.00 34.74  ? 223 GLU A CG  1 
ATOM   1295 C CD  . GLU A 1 223 ? -5.166  10.491  -6.086  1.00 43.93  ? 223 GLU A CD  1 
ATOM   1296 O OE1 . GLU A 1 223 ? -4.340  9.559   -6.086  1.00 44.95  ? 223 GLU A OE1 1 
ATOM   1297 O OE2 . GLU A 1 223 ? -4.959  11.582  -6.651  1.00 62.28  ? 223 GLU A OE2 1 
ATOM   1298 N N   . ASP A 1 224 ? -6.846  6.742   -7.928  1.00 33.14  ? 224 ASP A N   1 
ATOM   1299 C CA  . ASP A 1 224 ? -7.242  5.929   -9.067  1.00 29.36  ? 224 ASP A CA  1 
ATOM   1300 C C   . ASP A 1 224 ? -7.605  4.512   -8.618  1.00 32.47  ? 224 ASP A C   1 
ATOM   1301 O O   . ASP A 1 224 ? -8.727  4.027   -8.833  1.00 28.04  ? 224 ASP A O   1 
ATOM   1302 C CB  . ASP A 1 224 ? -6.089  5.908   -10.066 1.00 31.55  ? 224 ASP A CB  1 
ATOM   1303 C CG  . ASP A 1 224 ? -5.900  7.232   -10.780 1.00 47.41  ? 224 ASP A CG  1 
ATOM   1304 O OD1 . ASP A 1 224 ? -6.662  7.523   -11.744 1.00 50.37  ? 224 ASP A OD1 1 
ATOM   1305 O OD2 . ASP A 1 224 ? -4.961  7.974   -10.381 1.00 55.33  ? 224 ASP A OD2 1 
ATOM   1306 N N   . ILE A 1 225 ? -6.654  3.859   -7.951  1.00 28.39  ? 225 ILE A N   1 
ATOM   1307 C CA  . ILE A 1 225 ? -6.901  2.553   -7.371  1.00 24.43  ? 225 ILE A CA  1 
ATOM   1308 C C   . ILE A 1 225 ? -8.129  2.582   -6.470  1.00 29.69  ? 225 ILE A C   1 
ATOM   1309 O O   . ILE A 1 225 ? -9.058  1.775   -6.621  1.00 33.29  ? 225 ILE A O   1 
ATOM   1310 C CB  . ILE A 1 225 ? -5.666  2.090   -6.598  1.00 25.93  ? 225 ILE A CB  1 
ATOM   1311 C CG1 . ILE A 1 225 ? -4.489  1.963   -7.549  1.00 29.81  ? 225 ILE A CG1 1 
ATOM   1312 C CG2 . ILE A 1 225 ? -5.976  0.809   -5.881  1.00 27.17  ? 225 ILE A CG2 1 
ATOM   1313 C CD1 . ILE A 1 225 ? -3.169  1.794   -6.863  1.00 35.33  ? 225 ILE A CD1 1 
ATOM   1314 N N   . ALA A 1 226 ? -8.153  3.497   -5.508  1.00 26.48  ? 226 ALA A N   1 
ATOM   1315 C CA  . ALA A 1 226 ? -9.236  3.462   -4.536  1.00 26.79  ? 226 ALA A CA  1 
ATOM   1316 C C   . ALA A 1 226 ? -10.585 3.721   -5.179  1.00 28.39  ? 226 ALA A C   1 
ATOM   1317 O O   . ALA A 1 226 ? -11.601 3.221   -4.686  1.00 30.84  ? 226 ALA A O   1 
ATOM   1318 C CB  . ALA A 1 226 ? -8.988  4.464   -3.420  1.00 33.64  ? 226 ALA A CB  1 
ATOM   1319 N N   . GLU A 1 227 ? -10.622 4.472   -6.284  1.00 30.07  ? 227 GLU A N   1 
ATOM   1320 C CA  . GLU A 1 227 ? -11.872 4.621   -7.031  1.00 30.99  ? 227 GLU A CA  1 
ATOM   1321 C C   . GLU A 1 227 ? -12.279 3.316   -7.722  1.00 27.92  ? 227 GLU A C   1 
ATOM   1322 O O   . GLU A 1 227 ? -13.472 2.999   -7.805  1.00 24.63  ? 227 GLU A O   1 
ATOM   1323 C CB  . GLU A 1 227 ? -11.749 5.731   -8.066  1.00 32.50  ? 227 GLU A CB  1 
ATOM   1324 C CG  . GLU A 1 227 ? -13.089 6.079   -8.672  1.00 38.86  ? 227 GLU A CG  1 
ATOM   1325 C CD  . GLU A 1 227 ? -13.057 7.316   -9.529  1.00 42.18  ? 227 GLU A CD  1 
ATOM   1326 O OE1 . GLU A 1 227 ? -12.197 8.187   -9.264  1.00 44.44  ? 227 GLU A OE1 1 
ATOM   1327 O OE2 . GLU A 1 227 ? -13.926 7.415   -10.437 1.00 40.57  ? 227 GLU A OE2 1 
ATOM   1328 N N   . PHE A 1 228 ? -11.307 2.555   -8.246  1.00 25.20  ? 228 PHE A N   1 
ATOM   1329 C CA  . PHE A 1 228 ? -11.629 1.220   -8.728  1.00 24.03  ? 228 PHE A CA  1 
ATOM   1330 C C   . PHE A 1 228 ? -12.145 0.336   -7.597  1.00 29.92  ? 228 PHE A C   1 
ATOM   1331 O O   . PHE A 1 228 ? -13.122 -0.412  -7.779  1.00 27.38  ? 228 PHE A O   1 
ATOM   1332 C CB  . PHE A 1 228 ? -10.421 0.569   -9.382  1.00 24.22  ? 228 PHE A CB  1 
ATOM   1333 C CG  . PHE A 1 228 ? -10.092 1.119   -10.736 1.00 28.91  ? 228 PHE A CG  1 
ATOM   1334 C CD1 . PHE A 1 228 ? -11.023 1.090   -11.750 1.00 28.47  ? 228 PHE A CD1 1 
ATOM   1335 C CD2 . PHE A 1 228 ? -8.822  1.591   -11.021 1.00 30.37  ? 228 PHE A CD2 1 
ATOM   1336 C CE1 . PHE A 1 228 ? -10.714 1.581   -12.987 1.00 30.01  ? 228 PHE A CE1 1 
ATOM   1337 C CE2 . PHE A 1 228 ? -8.512  2.071   -12.259 1.00 27.83  ? 228 PHE A CE2 1 
ATOM   1338 C CZ  . PHE A 1 228 ? -9.456  2.064   -13.240 1.00 30.79  ? 228 PHE A CZ  1 
ATOM   1339 N N   . TYR A 1 229 ? -11.516 0.414   -6.413  1.00 25.53  ? 229 TYR A N   1 
ATOM   1340 C CA  . TYR A 1 229 ? -11.938 -0.450  -5.314  1.00 24.00  ? 229 TYR A CA  1 
ATOM   1341 C C   . TYR A 1 229 ? -13.403 -0.236  -4.968  1.00 23.34  ? 229 TYR A C   1 
ATOM   1342 O O   . TYR A 1 229 ? -14.154 -1.198  -4.805  1.00 22.46  ? 229 TYR A O   1 
ATOM   1343 C CB  . TYR A 1 229 ? -11.099 -0.218  -4.077  1.00 24.24  ? 229 TYR A CB  1 
ATOM   1344 C CG  . TYR A 1 229 ? -11.372 -1.250  -3.016  1.00 21.81  ? 229 TYR A CG  1 
ATOM   1345 C CD1 . TYR A 1 229 ? -11.127 -2.599  -3.251  1.00 30.64  ? 229 TYR A CD1 1 
ATOM   1346 C CD2 . TYR A 1 229 ? -11.899 -0.898  -1.816  1.00 19.78  ? 229 TYR A CD2 1 
ATOM   1347 C CE1 . TYR A 1 229 ? -11.370 -3.566  -2.286  1.00 26.56  ? 229 TYR A CE1 1 
ATOM   1348 C CE2 . TYR A 1 229 ? -12.159 -1.847  -0.849  1.00 27.81  ? 229 TYR A CE2 1 
ATOM   1349 C CZ  . TYR A 1 229 ? -11.889 -3.181  -1.087  1.00 29.66  ? 229 TYR A CZ  1 
ATOM   1350 O OH  . TYR A 1 229 ? -12.156 -4.107  -0.104  1.00 32.58  ? 229 TYR A OH  1 
ATOM   1351 N N   . LYS A 1 230 ? -13.830 1.026   -4.849  1.00 27.26  ? 230 LYS A N   1 
ATOM   1352 C CA  . LYS A 1 230 ? -15.224 1.285   -4.514  1.00 23.54  ? 230 LYS A CA  1 
ATOM   1353 C C   . LYS A 1 230 ? -16.138 0.803   -5.609  1.00 25.01  ? 230 LYS A C   1 
ATOM   1354 O O   . LYS A 1 230 ? -17.281 0.402   -5.339  1.00 27.50  ? 230 LYS A O   1 
ATOM   1355 C CB  . LYS A 1 230 ? -15.469 2.765   -4.249  1.00 22.69  ? 230 LYS A CB  1 
ATOM   1356 C CG  . LYS A 1 230 ? -15.164 3.175   -2.815  1.00 26.59  ? 230 LYS A CG  1 
ATOM   1357 C CD  . LYS A 1 230 ? -15.540 4.620   -2.513  1.00 32.08  ? 230 LYS A CD  1 
ATOM   1358 C CE  . LYS A 1 230 ? -17.046 4.852   -2.318  1.00 38.13  ? 230 LYS A CE  1 
ATOM   1359 N NZ  . LYS A 1 230 ? -17.265 6.195   -1.645  1.00 50.64  ? 230 LYS A NZ  1 
ATOM   1360 N N   . ARG A 1 231 ? -15.651 0.795   -6.848  1.00 27.92  ? 231 ARG A N   1 
ATOM   1361 C CA  . ARG A 1 231 ? -16.512 0.329   -7.921  1.00 29.68  ? 231 ARG A CA  1 
ATOM   1362 C C   . ARG A 1 231 ? -16.668 -1.185  -7.843  1.00 24.66  ? 231 ARG A C   1 
ATOM   1363 O O   . ARG A 1 231 ? -17.790 -1.695  -7.925  1.00 21.74  ? 231 ARG A O   1 
ATOM   1364 C CB  . ARG A 1 231 ? -15.964 0.773   -9.276  1.00 30.92  ? 231 ARG A CB  1 
ATOM   1365 C CG  . ARG A 1 231 ? -17.044 0.740   -10.352 1.00 36.50  ? 231 ARG A CG  1 
ATOM   1366 C CD  . ARG A 1 231 ? -16.571 1.143   -11.736 1.00 32.62  ? 231 ARG A CD  1 
ATOM   1367 N NE  . ARG A 1 231 ? -16.101 2.517   -11.749 1.00 31.94  ? 231 ARG A NE  1 
ATOM   1368 C CZ  . ARG A 1 231 ? -14.956 2.851   -12.332 1.00 41.88  ? 231 ARG A CZ  1 
ATOM   1369 N NH1 . ARG A 1 231 ? -14.269 1.915   -12.981 1.00 34.82  ? 231 ARG A NH1 1 
ATOM   1370 N NH2 . ARG A 1 231 ? -14.507 4.108   -12.305 1.00 46.05  ? 231 ARG A NH2 1 
ATOM   1371 N N   . GLN A 1 232 ? -15.558 -1.907  -7.620  1.00 20.42  ? 232 GLN A N   1 
ATOM   1372 C CA  . GLN A 1 232 ? -15.625 -3.358  -7.442  1.00 21.57  ? 232 GLN A CA  1 
ATOM   1373 C C   . GLN A 1 232 ? -16.630 -3.718  -6.347  1.00 24.20  ? 232 GLN A C   1 
ATOM   1374 O O   . GLN A 1 232 ? -17.502 -4.577  -6.537  1.00 23.51  ? 232 GLN A O   1 
ATOM   1375 C CB  . GLN A 1 232 ? -14.230 -3.921  -7.113  1.00 22.11  ? 232 GLN A CB  1 
ATOM   1376 C CG  . GLN A 1 232 ? -14.037 -5.454  -7.314  1.00 20.15  ? 232 GLN A CG  1 
ATOM   1377 C CD  . GLN A 1 232 ? -12.686 -5.996  -6.754  1.00 31.39  ? 232 GLN A CD  1 
ATOM   1378 O OE1 . GLN A 1 232 ? -11.726 -5.247  -6.570  1.00 36.33  ? 232 GLN A OE1 1 
ATOM   1379 N NE2 . GLN A 1 232 ? -12.643 -7.298  -6.438  1.00 26.75  ? 232 GLN A NE2 1 
ATOM   1380 N N   . LEU A 1 233 ? -16.543 -3.038  -5.197  1.00 22.55  ? 233 LEU A N   1 
ATOM   1381 C CA  . LEU A 1 233 ? -17.502 -3.271  -4.122  1.00 21.16  ? 233 LEU A CA  1 
ATOM   1382 C C   . LEU A 1 233 ? -18.939 -3.071  -4.587  1.00 22.45  ? 233 LEU A C   1 
ATOM   1383 O O   . LEU A 1 233 ? -19.778 -3.955  -4.406  1.00 24.53  ? 233 LEU A O   1 
ATOM   1384 C CB  . LEU A 1 233 ? -17.225 -2.365  -2.927  1.00 19.75  ? 233 LEU A CB  1 
ATOM   1385 C CG  . LEU A 1 233 ? -15.974 -2.589  -2.103  1.00 20.85  ? 233 LEU A CG  1 
ATOM   1386 C CD1 . LEU A 1 233 ? -16.107 -1.817  -0.849  1.00 18.52  ? 233 LEU A CD1 1 
ATOM   1387 C CD2 . LEU A 1 233 ? -15.763 -4.039  -1.796  1.00 27.21  ? 233 LEU A CD2 1 
ATOM   1388 N N   . LYS A 1 234 ? -19.263 -1.904  -5.153  1.00 23.15  ? 234 LYS A N   1 
ATOM   1389 C CA  . LYS A 1 234 ? -20.667 -1.661  -5.476  1.00 27.65  ? 234 LYS A CA  1 
ATOM   1390 C C   . LYS A 1 234 ? -21.154 -2.632  -6.555  1.00 28.19  ? 234 LYS A C   1 
ATOM   1391 O O   . LYS A 1 234 ? -22.276 -3.144  -6.490  1.00 29.49  ? 234 LYS A O   1 
ATOM   1392 C CB  . LYS A 1 234 ? -20.870 -0.215  -5.922  1.00 29.75  ? 234 LYS A CB  1 
ATOM   1393 C CG  . LYS A 1 234 ? -22.335 0.172   -6.071  1.00 34.09  ? 234 LYS A CG  1 
ATOM   1394 C CD  . LYS A 1 234 ? -22.607 1.165   -7.225  1.00 47.87  ? 234 LYS A CD  1 
ATOM   1395 C CE  . LYS A 1 234 ? -22.414 0.537   -8.629  1.00 50.51  ? 234 LYS A CE  1 
ATOM   1396 N NZ  . LYS A 1 234 ? -22.600 1.511   -9.771  1.00 57.20  ? 234 LYS A NZ  1 
ATOM   1397 N N   . LEU A 1 235 ? -20.303 -2.937  -7.529  1.00 28.24  ? 235 LEU A N   1 
ATOM   1398 C CA  . LEU A 1 235 ? -20.707 -3.838  -8.596  1.00 25.48  ? 235 LEU A CA  1 
ATOM   1399 C C   . LEU A 1 235 ? -20.800 -5.282  -8.120  1.00 24.10  ? 235 LEU A C   1 
ATOM   1400 O O   . LEU A 1 235 ? -21.655 -6.026  -8.602  1.00 24.81  ? 235 LEU A O   1 
ATOM   1401 C CB  . LEU A 1 235 ? -19.754 -3.722  -9.792  1.00 27.04  ? 235 LEU A CB  1 
ATOM   1402 C CG  . LEU A 1 235 ? -19.789 -2.381  -10.524 1.00 24.30  ? 235 LEU A CG  1 
ATOM   1403 C CD1 . LEU A 1 235 ? -18.943 -2.414  -11.738 1.00 23.24  ? 235 LEU A CD1 1 
ATOM   1404 C CD2 . LEU A 1 235 ? -21.213 -2.030  -10.877 1.00 30.21  ? 235 LEU A CD2 1 
ATOM   1405 N N   . THR A 1 236 ? -19.927 -5.719  -7.205  1.00 21.46  ? 236 THR A N   1 
ATOM   1406 C CA  . THR A 1 236 ? -20.136 -7.036  -6.617  1.00 17.66  ? 236 THR A CA  1 
ATOM   1407 C C   . THR A 1 236 ? -21.503 -7.165  -5.982  1.00 24.29  ? 236 THR A C   1 
ATOM   1408 O O   . THR A 1 236 ? -22.178 -8.184  -6.159  1.00 26.08  ? 236 THR A O   1 
ATOM   1409 C CB  . THR A 1 236 ? -19.081 -7.347  -5.592  1.00 20.90  ? 236 THR A CB  1 
ATOM   1410 O OG1 . THR A 1 236 ? -17.818 -7.576  -6.246  1.00 31.12  ? 236 THR A OG1 1 
ATOM   1411 C CG2 . THR A 1 236 ? -19.499 -8.529  -4.802  1.00 22.52  ? 236 THR A CG2 1 
ATOM   1412 N N   . GLN A 1 237 ? -21.963 -6.130  -5.270  1.00 27.60  ? 237 GLN A N   1 
ATOM   1413 C CA  . GLN A 1 237 ? -23.317 -6.177  -4.727  1.00 23.14  ? 237 GLN A CA  1 
ATOM   1414 C C   . GLN A 1 237 ? -24.348 -6.115  -5.843  1.00 27.52  ? 237 GLN A C   1 
ATOM   1415 O O   . GLN A 1 237 ? -25.259 -6.944  -5.895  1.00 28.31  ? 237 GLN A O   1 
ATOM   1416 C CB  . GLN A 1 237 ? -23.543 -5.050  -3.739  1.00 24.35  ? 237 GLN A CB  1 
ATOM   1417 C CG  . GLN A 1 237 ? -24.987 -4.913  -3.293  1.00 31.35  ? 237 GLN A CG  1 
ATOM   1418 C CD  . GLN A 1 237 ? -25.819 -3.982  -4.172  1.00 31.69  ? 237 GLN A CD  1 
ATOM   1419 O OE1 . GLN A 1 237 ? -25.463 -2.822  -4.394  1.00 31.08  ? 237 GLN A OE1 1 
ATOM   1420 N NE2 . GLN A 1 237 ? -26.957 -4.485  -4.648  1.00 33.05  ? 237 GLN A NE2 1 
ATOM   1421 N N   . GLU A 1 238 ? -24.222 -5.150  -6.761  1.00 28.70  ? 238 GLU A N   1 
ATOM   1422 C CA  . GLU A 1 238 ? -25.271 -4.977  -7.768  1.00 29.83  ? 238 GLU A CA  1 
ATOM   1423 C C   . GLU A 1 238 ? -25.343 -6.163  -8.713  1.00 25.83  ? 238 GLU A C   1 
ATOM   1424 O O   . GLU A 1 238 ? -26.435 -6.640  -9.016  1.00 28.26  ? 238 GLU A O   1 
ATOM   1425 C CB  . GLU A 1 238 ? -25.088 -3.688  -8.568  1.00 32.21  ? 238 GLU A CB  1 
ATOM   1426 C CG  . GLU A 1 238 ? -25.670 -2.431  -7.911  1.00 40.04  ? 238 GLU A CG  1 
ATOM   1427 C CD  . GLU A 1 238 ? -25.481 -1.184  -8.787  1.00 59.34  ? 238 GLU A CD  1 
ATOM   1428 O OE1 . GLU A 1 238 ? -25.326 -1.368  -10.034 1.00 66.92  ? 238 GLU A OE1 1 
ATOM   1429 O OE2 . GLU A 1 238 ? -25.515 -0.039  -8.242  1.00 50.83  ? 238 GLU A OE2 1 
ATOM   1430 N N   . TYR A 1 239 ? -24.199 -6.635  -9.208  1.00 23.54  ? 239 TYR A N   1 
ATOM   1431 C CA  . TYR A 1 239 ? -24.195 -7.839  -10.038 1.00 24.93  ? 239 TYR A CA  1 
ATOM   1432 C C   . TYR A 1 239 ? -24.813 -9.043  -9.325  1.00 27.59  ? 239 TYR A C   1 
ATOM   1433 O O   . TYR A 1 239 ? -25.655 -9.741  -9.904  1.00 29.24  ? 239 TYR A O   1 
ATOM   1434 C CB  . TYR A 1 239 ? -22.782 -8.177  -10.481 1.00 22.05  ? 239 TYR A CB  1 
ATOM   1435 C CG  . TYR A 1 239 ? -22.190 -7.200  -11.472 1.00 30.47  ? 239 TYR A CG  1 
ATOM   1436 C CD1 . TYR A 1 239 ? -23.002 -6.334  -12.220 1.00 29.47  ? 239 TYR A CD1 1 
ATOM   1437 C CD2 . TYR A 1 239 ? -20.812 -7.142  -11.666 1.00 27.11  ? 239 TYR A CD2 1 
ATOM   1438 C CE1 . TYR A 1 239 ? -22.445 -5.447  -13.132 1.00 27.12  ? 239 TYR A CE1 1 
ATOM   1439 C CE2 . TYR A 1 239 ? -20.255 -6.265  -12.567 1.00 29.21  ? 239 TYR A CE2 1 
ATOM   1440 C CZ  . TYR A 1 239 ? -21.063 -5.415  -13.303 1.00 31.77  ? 239 TYR A CZ  1 
ATOM   1441 O OH  . TYR A 1 239 ? -20.461 -4.549  -14.209 1.00 35.87  ? 239 TYR A OH  1 
ATOM   1442 N N   . THR A 1 240 ? -24.394 -9.335  -8.085  1.00 22.75  ? 240 THR A N   1 
ATOM   1443 C CA  . THR A 1 240 ? -24.976 -10.490 -7.403  1.00 22.20  ? 240 THR A CA  1 
ATOM   1444 C C   . THR A 1 240 ? -26.496 -10.362 -7.289  1.00 26.89  ? 240 THR A C   1 
ATOM   1445 O O   . THR A 1 240 ? -27.240 -11.230 -7.739  1.00 26.51  ? 240 THR A O   1 
ATOM   1446 C CB  . THR A 1 240 ? -24.370 -10.674 -6.019  1.00 23.23  ? 240 THR A CB  1 
ATOM   1447 O OG1 . THR A 1 240 ? -22.975 -10.950 -6.108  1.00 25.89  ? 240 THR A OG1 1 
ATOM   1448 C CG2 . THR A 1 240 ? -25.037 -11.816 -5.341  1.00 25.68  ? 240 THR A CG2 1 
ATOM   1449 N N   . ASP A 1 241 ? -26.975 -9.269  -6.691  1.00 31.56  ? 241 ASP A N   1 
ATOM   1450 C CA  . ASP A 1 241 ? -28.394 -9.123  -6.420  1.00 25.61  ? 241 ASP A CA  1 
ATOM   1451 C C   . ASP A 1 241 ? -29.211 -9.205  -7.701  1.00 32.85  ? 241 ASP A C   1 
ATOM   1452 O O   . ASP A 1 241 ? -30.330 -9.741  -7.699  1.00 40.46  ? 241 ASP A O   1 
ATOM   1453 C CB  . ASP A 1 241 ? -28.640 -7.806  -5.678  1.00 26.11  ? 241 ASP A CB  1 
ATOM   1454 C CG  . ASP A 1 241 ? -28.251 -7.874  -4.182  1.00 35.18  ? 241 ASP A CG  1 
ATOM   1455 O OD1 . ASP A 1 241 ? -28.299 -8.981  -3.600  1.00 36.25  ? 241 ASP A OD1 1 
ATOM   1456 O OD2 . ASP A 1 241 ? -27.891 -6.827  -3.577  1.00 35.53  ? 241 ASP A OD2 1 
ATOM   1457 N N   . HIS A 1 242 ? -28.671 -8.701  -8.807  1.00 32.87  ? 242 HIS A N   1 
ATOM   1458 C CA  . HIS A 1 242 ? -29.388 -8.789  -10.071 1.00 29.04  ? 242 HIS A CA  1 
ATOM   1459 C C   . HIS A 1 242 ? -29.605 -10.238 -10.441 1.00 35.58  ? 242 HIS A C   1 
ATOM   1460 O O   . HIS A 1 242 ? -30.714 -10.634 -10.806 1.00 39.41  ? 242 HIS A O   1 
ATOM   1461 C CB  . HIS A 1 242 ? -28.605 -8.040  -11.151 1.00 31.02  ? 242 HIS A CB  1 
ATOM   1462 C CG  . HIS A 1 242 ? -29.222 -8.081  -12.516 1.00 35.54  ? 242 HIS A CG  1 
ATOM   1463 N ND1 . HIS A 1 242 ? -28.980 -9.096  -13.415 1.00 39.38  ? 242 HIS A ND1 1 
ATOM   1464 C CD2 . HIS A 1 242 ? -30.053 -7.216  -13.145 1.00 36.61  ? 242 HIS A CD2 1 
ATOM   1465 C CE1 . HIS A 1 242 ? -29.633 -8.856  -14.539 1.00 40.12  ? 242 HIS A CE1 1 
ATOM   1466 N NE2 . HIS A 1 242 ? -30.302 -7.727  -14.396 1.00 38.41  ? 242 HIS A NE2 1 
ATOM   1467 N N   . CYS A 1 243 ? -28.565 -11.058 -10.275 1.00 38.57  ? 243 CYS A N   1 
ATOM   1468 C CA  . CYS A 1 243 ? -28.610 -12.441 -10.729 1.00 30.79  ? 243 CYS A CA  1 
ATOM   1469 C C   . CYS A 1 243 ? -29.589 -13.250 -9.907  1.00 32.05  ? 243 CYS A C   1 
ATOM   1470 O O   . CYS A 1 243 ? -30.349 -14.040 -10.466 1.00 38.15  ? 243 CYS A O   1 
ATOM   1471 C CB  . CYS A 1 243 ? -27.220 -13.060 -10.663 1.00 30.56  ? 243 CYS A CB  1 
ATOM   1472 S SG  . CYS A 1 243 ? -26.164 -12.484 -11.989 1.00 33.71  ? 243 CYS A SG  1 
ATOM   1473 N N   . VAL A 1 244 ? -29.606 -13.063 -8.586  1.00 27.41  ? 244 VAL A N   1 
ATOM   1474 C CA  . VAL A 1 244 ? -30.581 -13.788 -7.782  1.00 25.69  ? 244 VAL A CA  1 
ATOM   1475 C C   . VAL A 1 244 ? -31.987 -13.327 -8.139  1.00 30.63  ? 244 VAL A C   1 
ATOM   1476 O O   . VAL A 1 244 ? -32.898 -14.144 -8.305  1.00 30.87  ? 244 VAL A O   1 
ATOM   1477 C CB  . VAL A 1 244 ? -30.297 -13.613 -6.281  1.00 21.93  ? 244 VAL A CB  1 
ATOM   1478 C CG1 . VAL A 1 244 ? -31.376 -14.306 -5.453  1.00 18.18  ? 244 VAL A CG1 1 
ATOM   1479 C CG2 . VAL A 1 244 ? -28.867 -14.039 -5.914  1.00 20.65  ? 244 VAL A CG2 1 
ATOM   1480 N N   . LYS A 1 245 ? -32.187 -12.012 -8.295  1.00 33.91  ? 245 LYS A N   1 
ATOM   1481 C CA  . LYS A 1 245 ? -33.539 -11.523 -8.565  1.00 34.21  ? 245 LYS A CA  1 
ATOM   1482 C C   . LYS A 1 245 ? -34.104 -12.202 -9.790  1.00 36.11  ? 245 LYS A C   1 
ATOM   1483 O O   . LYS A 1 245 ? -35.183 -12.791 -9.748  1.00 42.65  ? 245 LYS A O   1 
ATOM   1484 C CB  . LYS A 1 245 ? -33.570 -10.005 -8.755  1.00 33.16  ? 245 LYS A CB  1 
ATOM   1485 C CG  . LYS A 1 245 ? -34.992 -9.473  -8.976  1.00 39.49  ? 245 LYS A CG  1 
ATOM   1486 C CD  . LYS A 1 245 ? -35.063 -7.950  -9.135  1.00 40.02  ? 245 LYS A CD  1 
ATOM   1487 C CE  . LYS A 1 245 ? -36.497 -7.459  -9.386  1.00 39.65  ? 245 LYS A CE  1 
ATOM   1488 N NZ  . LYS A 1 245 ? -36.548 -5.971  -9.545  1.00 46.64  ? 245 LYS A NZ  1 
ATOM   1489 N N   . TRP A 1 246 ? -33.343 -12.194 -10.870 1.00 39.28  ? 246 TRP A N   1 
ATOM   1490 C CA  . TRP A 1 246 ? -33.847 -12.658 -12.144 1.00 37.46  ? 246 TRP A CA  1 
ATOM   1491 C C   . TRP A 1 246 ? -33.796 -14.164 -12.272 1.00 39.75  ? 246 TRP A C   1 
ATOM   1492 O O   . TRP A 1 246 ? -34.638 -14.746 -12.963 1.00 40.69  ? 246 TRP A O   1 
ATOM   1493 C CB  . TRP A 1 246 ? -33.073 -11.965 -13.243 1.00 36.26  ? 246 TRP A CB  1 
ATOM   1494 C CG  . TRP A 1 246 ? -33.525 -10.553 -13.281 1.00 44.20  ? 246 TRP A CG  1 
ATOM   1495 C CD1 . TRP A 1 246 ? -32.813 -9.453  -12.922 1.00 40.84  ? 246 TRP A CD1 1 
ATOM   1496 C CD2 . TRP A 1 246 ? -34.830 -10.081 -13.669 1.00 46.89  ? 246 TRP A CD2 1 
ATOM   1497 N NE1 . TRP A 1 246 ? -33.583 -8.329  -13.074 1.00 43.85  ? 246 TRP A NE1 1 
ATOM   1498 C CE2 . TRP A 1 246 ? -34.822 -8.687  -13.534 1.00 40.37  ? 246 TRP A CE2 1 
ATOM   1499 C CE3 . TRP A 1 246 ? -35.993 -10.708 -14.133 1.00 44.47  ? 246 TRP A CE3 1 
ATOM   1500 C CZ2 . TRP A 1 246 ? -35.926 -7.905  -13.830 1.00 42.97  ? 246 TRP A CZ2 1 
ATOM   1501 C CZ3 . TRP A 1 246 ? -37.086 -9.933  -14.415 1.00 47.71  ? 246 TRP A CZ3 1 
ATOM   1502 C CH2 . TRP A 1 246 ? -37.045 -8.540  -14.271 1.00 47.28  ? 246 TRP A CH2 1 
ATOM   1503 N N   . TYR A 1 247 ? -32.845 -14.816 -11.607 1.00 38.37  ? 247 TYR A N   1 
ATOM   1504 C CA  . TYR A 1 247 ? -32.903 -16.270 -11.527 1.00 41.83  ? 247 TYR A CA  1 
ATOM   1505 C C   . TYR A 1 247 ? -34.220 -16.720 -10.906 1.00 44.39  ? 247 TYR A C   1 
ATOM   1506 O O   . TYR A 1 247 ? -34.902 -17.606 -11.442 1.00 45.56  ? 247 TYR A O   1 
ATOM   1507 C CB  . TYR A 1 247 ? -31.728 -16.816 -10.726 1.00 37.65  ? 247 TYR A CB  1 
ATOM   1508 C CG  . TYR A 1 247 ? -32.003 -18.172 -10.161 1.00 33.27  ? 247 TYR A CG  1 
ATOM   1509 C CD1 . TYR A 1 247 ? -31.917 -19.305 -10.943 1.00 38.38  ? 247 TYR A CD1 1 
ATOM   1510 C CD2 . TYR A 1 247 ? -32.398 -18.310 -8.856  1.00 30.84  ? 247 TYR A CD2 1 
ATOM   1511 C CE1 . TYR A 1 247 ? -32.185 -20.566 -10.406 1.00 41.81  ? 247 TYR A CE1 1 
ATOM   1512 C CE2 . TYR A 1 247 ? -32.668 -19.538 -8.322  1.00 40.41  ? 247 TYR A CE2 1 
ATOM   1513 C CZ  . TYR A 1 247 ? -32.567 -20.671 -9.090  1.00 39.26  ? 247 TYR A CZ  1 
ATOM   1514 O OH  . TYR A 1 247 ? -32.851 -21.897 -8.510  1.00 42.59  ? 247 TYR A OH  1 
ATOM   1515 N N   . ASN A 1 248 ? -34.597 -16.117 -9.772  1.00 38.09  ? 248 ASN A N   1 
ATOM   1516 C CA  . ASN A 1 248 ? -35.822 -16.540 -9.100  1.00 41.13  ? 248 ASN A CA  1 
ATOM   1517 C C   . ASN A 1 248 ? -37.033 -16.251 -9.967  1.00 40.17  ? 248 ASN A C   1 
ATOM   1518 O O   . ASN A 1 248 ? -37.968 -17.061 -10.026 1.00 39.28  ? 248 ASN A O   1 
ATOM   1519 C CB  . ASN A 1 248 ? -35.967 -15.855 -7.739  1.00 34.03  ? 248 ASN A CB  1 
ATOM   1520 C CG  . ASN A 1 248 ? -35.148 -16.519 -6.673  1.00 32.04  ? 248 ASN A CG  1 
ATOM   1521 O OD1 . ASN A 1 248 ? -35.110 -17.744 -6.558  1.00 43.40  ? 248 ASN A OD1 1 
ATOM   1522 N ND2 . ASN A 1 248 ? -34.478 -15.719 -5.884  1.00 32.65  ? 248 ASN A ND2 1 
ATOM   1523 N N   . VAL A 1 249 ? -37.016 -15.111 -10.663 1.00 36.12  ? 249 VAL A N   1 
ATOM   1524 C CA  . VAL A 1 249 ? -38.143 -14.735 -11.507 1.00 39.84  ? 249 VAL A CA  1 
ATOM   1525 C C   . VAL A 1 249 ? -38.361 -15.774 -12.587 1.00 41.46  ? 249 VAL A C   1 
ATOM   1526 O O   . VAL A 1 249 ? -39.487 -16.220 -12.825 1.00 39.27  ? 249 VAL A O   1 
ATOM   1527 C CB  . VAL A 1 249 ? -37.911 -13.349 -12.117 1.00 39.13  ? 249 VAL A CB  1 
ATOM   1528 C CG1 . VAL A 1 249 ? -38.829 -13.158 -13.322 1.00 36.12  ? 249 VAL A CG1 1 
ATOM   1529 C CG2 . VAL A 1 249 ? -38.125 -12.298 -11.060 1.00 35.36  ? 249 VAL A CG2 1 
ATOM   1530 N N   . GLY A 1 250 ? -37.281 -16.168 -13.260 1.00 46.05  ? 250 GLY A N   1 
ATOM   1531 C CA  . GLY A 1 250 ? -37.385 -17.221 -14.252 1.00 45.03  ? 250 GLY A CA  1 
ATOM   1532 C C   . GLY A 1 250 ? -37.816 -18.538 -13.645 1.00 42.38  ? 250 GLY A C   1 
ATOM   1533 O O   . GLY A 1 250 ? -38.701 -19.214 -14.169 1.00 40.21  ? 250 GLY A O   1 
ATOM   1534 N N   . LEU A 1 251 ? -37.193 -18.915 -12.525 1.00 39.46  ? 251 LEU A N   1 
ATOM   1535 C CA  . LEU A 1 251 ? -37.535 -20.167 -11.861 1.00 37.37  ? 251 LEU A CA  1 
ATOM   1536 C C   . LEU A 1 251 ? -39.023 -20.239 -11.566 1.00 40.97  ? 251 LEU A C   1 
ATOM   1537 O O   . LEU A 1 251 ? -39.669 -21.254 -11.841 1.00 42.36  ? 251 LEU A O   1 
ATOM   1538 C CB  . LEU A 1 251 ? -36.747 -20.302 -10.563 1.00 44.43  ? 251 LEU A CB  1 
ATOM   1539 C CG  . LEU A 1 251 ? -36.866 -21.605 -9.775  1.00 42.60  ? 251 LEU A CG  1 
ATOM   1540 C CD1 . LEU A 1 251 ? -36.100 -22.746 -10.473 1.00 36.17  ? 251 LEU A CD1 1 
ATOM   1541 C CD2 . LEU A 1 251 ? -36.410 -21.380 -8.333  1.00 40.20  ? 251 LEU A CD2 1 
ATOM   1542 N N   . ASP A 1 252 ? -39.580 -19.160 -10.991 1.00 46.83  ? 252 ASP A N   1 
ATOM   1543 C CA  . ASP A 1 252 ? -41.015 -19.098 -10.700 1.00 41.52  ? 252 ASP A CA  1 
ATOM   1544 C C   . ASP A 1 252 ? -41.847 -19.202 -11.973 1.00 42.56  ? 252 ASP A C   1 
ATOM   1545 O O   . ASP A 1 252 ? -42.911 -19.834 -11.981 1.00 41.17  ? 252 ASP A O   1 
ATOM   1546 C CB  . ASP A 1 252 ? -41.357 -17.798 -9.970  1.00 36.82  ? 252 ASP A CB  1 
ATOM   1547 C CG  . ASP A 1 252 ? -40.864 -17.776 -8.537  1.00 37.19  ? 252 ASP A CG  1 
ATOM   1548 O OD1 . ASP A 1 252 ? -40.725 -18.864 -7.933  1.00 44.27  ? 252 ASP A OD1 1 
ATOM   1549 O OD2 . ASP A 1 252 ? -40.660 -16.672 -7.991  1.00 36.95  ? 252 ASP A OD2 1 
ATOM   1550 N N   . LYS A 1 253 ? -41.364 -18.610 -13.068 1.00 40.37  ? 253 LYS A N   1 
ATOM   1551 C CA  . LYS A 1 253 ? -42.096 -18.594 -14.326 1.00 38.44  ? 253 LYS A CA  1 
ATOM   1552 C C   . LYS A 1 253 ? -42.211 -20.001 -14.913 1.00 43.32  ? 253 LYS A C   1 
ATOM   1553 O O   . LYS A 1 253 ? -42.773 -20.175 -15.995 1.00 47.83  ? 253 LYS A O   1 
ATOM   1554 C CB  . LYS A 1 253 ? -41.410 -17.659 -15.328 1.00 39.92  ? 253 LYS A CB  1 
ATOM   1555 C CG  . LYS A 1 253 ? -42.359 -16.739 -16.082 1.00 45.40  ? 253 LYS A CG  1 
ATOM   1556 C CD  . LYS A 1 253 ? -41.643 -15.820 -17.091 1.00 56.89  ? 253 LYS A CD  1 
ATOM   1557 C CE  . LYS A 1 253 ? -41.120 -14.521 -16.521 1.00 52.68  ? 253 LYS A CE  1 
ATOM   1558 N NZ  . LYS A 1 253 ? -40.224 -13.898 -17.548 1.00 64.54  ? 253 LYS A NZ  1 
ATOM   1559 N N   . LEU A 1 254 ? -41.675 -21.010 -14.215 1.00 44.17  ? 254 LEU A N   1 
ATOM   1560 C CA  . LEU A 1 254 ? -41.645 -22.388 -14.694 1.00 45.35  ? 254 LEU A CA  1 
ATOM   1561 C C   . LEU A 1 254 ? -42.340 -23.404 -13.787 1.00 51.09  ? 254 LEU A C   1 
ATOM   1562 O O   . LEU A 1 254 ? -42.553 -24.548 -14.230 1.00 52.83  ? 254 LEU A O   1 
ATOM   1563 C CB  . LEU A 1 254 ? -40.196 -22.850 -14.912 1.00 48.00  ? 254 LEU A CB  1 
ATOM   1564 C CG  . LEU A 1 254 ? -39.528 -22.533 -16.240 1.00 50.10  ? 254 LEU A CG  1 
ATOM   1565 C CD1 . LEU A 1 254 ? -38.016 -22.635 -16.094 1.00 45.54  ? 254 LEU A CD1 1 
ATOM   1566 C CD2 . LEU A 1 254 ? -40.034 -23.533 -17.232 1.00 54.44  ? 254 LEU A CD2 1 
ATOM   1567 N N   . ARG A 1 255 ? -42.687 -23.043 -12.545 1.00 46.75  ? 255 ARG A N   1 
ATOM   1568 C CA  . ARG A 1 255 ? -43.499 -23.931 -11.717 1.00 47.07  ? 255 ARG A CA  1 
ATOM   1569 C C   . ARG A 1 255 ? -44.814 -24.242 -12.433 1.00 49.38  ? 255 ARG A C   1 
ATOM   1570 O O   . ARG A 1 255 ? -45.471 -23.356 -12.991 1.00 43.84  ? 255 ARG A O   1 
ATOM   1571 C CB  . ARG A 1 255 ? -43.782 -23.311 -10.344 1.00 35.86  ? 255 ARG A CB  1 
ATOM   1572 C CG  . ARG A 1 255 ? -42.670 -22.436 -9.804  1.00 41.00  ? 255 ARG A CG  1 
ATOM   1573 C CD  . ARG A 1 255 ? -42.931 -21.965 -8.361  1.00 43.50  ? 255 ARG A CD  1 
ATOM   1574 N NE  . ARG A 1 255 ? -42.258 -22.843 -7.413  1.00 43.39  ? 255 ARG A NE  1 
ATOM   1575 C CZ  . ARG A 1 255 ? -41.016 -22.652 -6.987  1.00 45.94  ? 255 ARG A CZ  1 
ATOM   1576 N NH1 . ARG A 1 255 ? -40.324 -21.592 -7.401  1.00 40.75  ? 255 ARG A NH1 1 
ATOM   1577 N NH2 . ARG A 1 255 ? -40.468 -23.521 -6.141  1.00 46.87  ? 255 ARG A NH2 1 
ATOM   1578 N N   . GLY A 1 256 ? -45.174 -25.514 -12.445 1.00 48.66  ? 256 GLY A N   1 
ATOM   1579 C CA  . GLY A 1 256 ? -46.445 -25.919 -12.985 1.00 43.07  ? 256 GLY A CA  1 
ATOM   1580 C C   . GLY A 1 256 ? -46.958 -27.112 -12.217 1.00 45.61  ? 256 GLY A C   1 
ATOM   1581 O O   . GLY A 1 256 ? -46.732 -27.251 -11.008 1.00 41.25  ? 256 GLY A O   1 
ATOM   1582 N N   . SER A 1 257 ? -47.637 -27.999 -12.918 1.00 44.41  ? 257 SER A N   1 
ATOM   1583 C CA  . SER A 1 257 ? -48.263 -29.114 -12.254 1.00 44.61  ? 257 SER A CA  1 
ATOM   1584 C C   . SER A 1 257 ? -47.836 -30.473 -12.781 1.00 51.41  ? 257 SER A C   1 
ATOM   1585 O O   . SER A 1 257 ? -47.935 -31.451 -12.027 1.00 55.59  ? 257 SER A O   1 
ATOM   1586 C CB  . SER A 1 257 ? -49.785 -28.983 -12.346 1.00 47.66  ? 257 SER A CB  1 
ATOM   1587 O OG  . SER A 1 257 ? -50.217 -29.120 -13.687 1.00 56.90  ? 257 SER A OG  1 
ATOM   1588 N N   . SER A 1 258 ? -47.328 -30.566 -14.013 1.00 42.57  ? 258 SER A N   1 
ATOM   1589 C CA  . SER A 1 258 ? -47.020 -31.857 -14.614 1.00 42.02  ? 258 SER A CA  1 
ATOM   1590 C C   . SER A 1 258 ? -45.540 -32.194 -14.483 1.00 49.12  ? 258 SER A C   1 
ATOM   1591 O O   . SER A 1 258 ? -44.680 -31.307 -14.388 1.00 47.79  ? 258 SER A O   1 
ATOM   1592 C CB  . SER A 1 258 ? -47.389 -31.882 -16.091 1.00 41.54  ? 258 SER A CB  1 
ATOM   1593 O OG  . SER A 1 258 ? -46.576 -30.976 -16.812 1.00 43.27  ? 258 SER A OG  1 
ATOM   1594 N N   . TYR A 1 259 ? -45.256 -33.506 -14.493 1.00 49.04  ? 259 TYR A N   1 
ATOM   1595 C CA  . TYR A 1 259 ? -43.882 -33.981 -14.628 1.00 42.45  ? 259 TYR A CA  1 
ATOM   1596 C C   . TYR A 1 259 ? -43.155 -33.178 -15.702 1.00 38.90  ? 259 TYR A C   1 
ATOM   1597 O O   . TYR A 1 259 ? -42.065 -32.660 -15.462 1.00 38.08  ? 259 TYR A O   1 
ATOM   1598 C CB  . TYR A 1 259 ? -43.884 -35.493 -14.913 1.00 41.35  ? 259 TYR A CB  1 
ATOM   1599 C CG  . TYR A 1 259 ? -42.553 -36.094 -15.357 1.00 42.24  ? 259 TYR A CG  1 
ATOM   1600 C CD1 . TYR A 1 259 ? -42.203 -36.084 -16.701 1.00 40.14  ? 259 TYR A CD1 1 
ATOM   1601 C CD2 . TYR A 1 259 ? -41.654 -36.686 -14.444 1.00 42.06  ? 259 TYR A CD2 1 
ATOM   1602 C CE1 . TYR A 1 259 ? -41.010 -36.603 -17.138 1.00 35.67  ? 259 TYR A CE1 1 
ATOM   1603 C CE2 . TYR A 1 259 ? -40.427 -37.219 -14.879 1.00 36.95  ? 259 TYR A CE2 1 
ATOM   1604 C CZ  . TYR A 1 259 ? -40.124 -37.161 -16.248 1.00 41.42  ? 259 TYR A CZ  1 
ATOM   1605 O OH  . TYR A 1 259 ? -38.953 -37.665 -16.785 1.00 44.96  ? 259 TYR A OH  1 
ATOM   1606 N N   . GLU A 1 260 ? -43.789 -32.997 -16.863 1.00 39.64  ? 260 GLU A N   1 
ATOM   1607 C CA  . GLU A 1 260 ? -43.263 -32.135 -17.927 1.00 52.25  ? 260 GLU A CA  1 
ATOM   1608 C C   . GLU A 1 260 ? -42.831 -30.738 -17.429 1.00 51.14  ? 260 GLU A C   1 
ATOM   1609 O O   . GLU A 1 260 ? -41.685 -30.319 -17.654 1.00 51.98  ? 260 GLU A O   1 
ATOM   1610 C CB  . GLU A 1 260 ? -44.302 -32.019 -19.059 1.00 49.55  ? 260 GLU A CB  1 
ATOM   1611 C CG  . GLU A 1 260 ? -44.409 -33.236 -19.988 1.00 52.06  ? 260 GLU A CG  1 
ATOM   1612 C CD  . GLU A 1 260 ? -45.314 -34.391 -19.487 1.00 66.07  ? 260 GLU A CD  1 
ATOM   1613 O OE1 . GLU A 1 260 ? -46.326 -34.129 -18.792 1.00 67.85  ? 260 GLU A OE1 1 
ATOM   1614 O OE2 . GLU A 1 260 ? -45.030 -35.572 -19.829 1.00 66.61  ? 260 GLU A OE2 1 
ATOM   1615 N N   . SER A 1 261 ? -43.737 -29.975 -16.797 1.00 39.47  ? 261 SER A N   1 
ATOM   1616 C CA  . SER A 1 261 ? -43.333 -28.669 -16.268 1.00 39.34  ? 261 SER A CA  1 
ATOM   1617 C C   . SER A 1 261 ? -42.130 -28.808 -15.349 1.00 46.20  ? 261 SER A C   1 
ATOM   1618 O O   . SER A 1 261 ? -41.235 -27.955 -15.356 1.00 46.15  ? 261 SER A O   1 
ATOM   1619 C CB  . SER A 1 261 ? -44.472 -27.973 -15.488 1.00 47.58  ? 261 SER A CB  1 
ATOM   1620 O OG  . SER A 1 261 ? -45.710 -27.778 -16.180 1.00 49.59  ? 261 SER A OG  1 
ATOM   1621 N N   . TRP A 1 262 ? -42.099 -29.889 -14.549 1.00 47.18  ? 262 TRP A N   1 
ATOM   1622 C CA  . TRP A 1 262 ? -41.061 -30.084 -13.532 1.00 42.85  ? 262 TRP A CA  1 
ATOM   1623 C C   . TRP A 1 262 ? -39.674 -30.309 -14.142 1.00 42.71  ? 262 TRP A C   1 
ATOM   1624 O O   . TRP A 1 262 ? -38.681 -29.765 -13.653 1.00 38.69  ? 262 TRP A O   1 
ATOM   1625 C CB  . TRP A 1 262 ? -41.422 -31.259 -12.614 1.00 39.90  ? 262 TRP A CB  1 
ATOM   1626 C CG  . TRP A 1 262 ? -40.506 -31.295 -11.454 1.00 36.67  ? 262 TRP A CG  1 
ATOM   1627 C CD1 . TRP A 1 262 ? -40.652 -30.616 -10.302 1.00 37.39  ? 262 TRP A CD1 1 
ATOM   1628 C CD2 . TRP A 1 262 ? -39.256 -31.999 -11.354 1.00 36.89  ? 262 TRP A CD2 1 
ATOM   1629 N NE1 . TRP A 1 262 ? -39.582 -30.845 -9.473  1.00 38.22  ? 262 TRP A NE1 1 
ATOM   1630 C CE2 . TRP A 1 262 ? -38.708 -31.693 -10.092 1.00 36.94  ? 262 TRP A CE2 1 
ATOM   1631 C CE3 . TRP A 1 262 ? -38.547 -32.854 -12.208 1.00 40.24  ? 262 TRP A CE3 1 
ATOM   1632 C CZ2 . TRP A 1 262 ? -37.477 -32.207 -9.648  1.00 38.99  ? 262 TRP A CZ2 1 
ATOM   1633 C CZ3 . TRP A 1 262 ? -37.317 -33.387 -11.760 1.00 39.12  ? 262 TRP A CZ3 1 
ATOM   1634 C CH2 . TRP A 1 262 ? -36.799 -33.050 -10.488 1.00 36.67  ? 262 TRP A CH2 1 
ATOM   1635 N N   . VAL A 1 263 ? -39.573 -31.138 -15.182 1.00 43.00  ? 263 VAL A N   1 
ATOM   1636 C CA  . VAL A 1 263 ? -38.265 -31.393 -15.770 1.00 39.31  ? 263 VAL A CA  1 
ATOM   1637 C C   . VAL A 1 263 ? -37.693 -30.116 -16.376 1.00 45.71  ? 263 VAL A C   1 
ATOM   1638 O O   . VAL A 1 263 ? -36.492 -29.843 -16.255 1.00 47.31  ? 263 VAL A O   1 
ATOM   1639 C CB  . VAL A 1 263 ? -38.348 -32.536 -16.796 1.00 43.20  ? 263 VAL A CB  1 
ATOM   1640 C CG1 . VAL A 1 263 ? -37.041 -32.663 -17.564 1.00 41.55  ? 263 VAL A CG1 1 
ATOM   1641 C CG2 . VAL A 1 263 ? -38.669 -33.855 -16.098 1.00 42.79  ? 263 VAL A CG2 1 
ATOM   1642 N N   . ASN A 1 264 ? -38.534 -29.297 -17.014 1.00 44.43  ? 264 ASN A N   1 
ATOM   1643 C CA  . ASN A 1 264 ? -38.050 -27.986 -17.450 1.00 46.73  ? 264 ASN A CA  1 
ATOM   1644 C C   . ASN A 1 264 ? -37.600 -27.149 -16.265 1.00 42.73  ? 264 ASN A C   1 
ATOM   1645 O O   . ASN A 1 264 ? -36.566 -26.474 -16.322 1.00 49.30  ? 264 ASN A O   1 
ATOM   1646 C CB  . ASN A 1 264 ? -39.133 -27.230 -18.218 1.00 49.09  ? 264 ASN A CB  1 
ATOM   1647 C CG  . ASN A 1 264 ? -39.589 -27.971 -19.423 1.00 49.12  ? 264 ASN A CG  1 
ATOM   1648 O OD1 . ASN A 1 264 ? -38.919 -28.899 -19.873 1.00 48.82  ? 264 ASN A OD1 1 
ATOM   1649 N ND2 . ASN A 1 264 ? -40.751 -27.601 -19.942 1.00 49.44  ? 264 ASN A ND2 1 
ATOM   1650 N N   . PHE A 1 265 ? -38.390 -27.157 -15.197 1.00 43.74  ? 265 PHE A N   1 
ATOM   1651 C CA  . PHE A 1 265 ? -38.079 -26.390 -13.996 1.00 44.62  ? 265 PHE A CA  1 
ATOM   1652 C C   . PHE A 1 265 ? -36.718 -26.797 -13.451 1.00 44.43  ? 265 PHE A C   1 
ATOM   1653 O O   . PHE A 1 265 ? -35.792 -25.978 -13.348 1.00 42.58  ? 265 PHE A O   1 
ATOM   1654 C CB  . PHE A 1 265 ? -39.221 -26.643 -13.014 1.00 40.69  ? 265 PHE A CB  1 
ATOM   1655 C CG  . PHE A 1 265 ? -39.008 -26.188 -11.605 1.00 36.21  ? 265 PHE A CG  1 
ATOM   1656 C CD1 . PHE A 1 265 ? -39.212 -24.878 -11.245 1.00 39.60  ? 265 PHE A CD1 1 
ATOM   1657 C CD2 . PHE A 1 265 ? -38.794 -27.107 -10.606 1.00 34.25  ? 265 PHE A CD2 1 
ATOM   1658 C CE1 . PHE A 1 265 ? -39.119 -24.482 -9.906  1.00 35.34  ? 265 PHE A CE1 1 
ATOM   1659 C CE2 . PHE A 1 265 ? -38.707 -26.709 -9.292  1.00 35.91  ? 265 PHE A CE2 1 
ATOM   1660 C CZ  . PHE A 1 265 ? -38.872 -25.397 -8.945  1.00 30.83  ? 265 PHE A CZ  1 
ATOM   1661 N N   . ASN A 1 266 ? -36.558 -28.093 -13.192 1.00 41.66  ? 266 ASN A N   1 
ATOM   1662 C CA  . ASN A 1 266 ? -35.314 -28.611 -12.654 1.00 33.35  ? 266 ASN A CA  1 
ATOM   1663 C C   . ASN A 1 266 ? -34.159 -28.407 -13.619 1.00 36.87  ? 266 ASN A C   1 
ATOM   1664 O O   . ASN A 1 266 ? -33.036 -28.134 -13.191 1.00 38.25  ? 266 ASN A O   1 
ATOM   1665 C CB  . ASN A 1 266 ? -35.492 -30.081 -12.346 1.00 36.33  ? 266 ASN A CB  1 
ATOM   1666 C CG  . ASN A 1 266 ? -34.339 -30.640 -11.631 1.00 38.42  ? 266 ASN A CG  1 
ATOM   1667 O OD1 . ASN A 1 266 ? -33.978 -30.157 -10.566 1.00 41.06  ? 266 ASN A OD1 1 
ATOM   1668 N ND2 . ASN A 1 266 ? -33.714 -31.650 -12.214 1.00 42.61  ? 266 ASN A ND2 1 
ATOM   1669 N N   . ARG A 1 267 ? -34.402 -28.554 -14.929 1.00 45.35  ? 267 ARG A N   1 
ATOM   1670 C CA  . ARG A 1 267 ? -33.332 -28.321 -15.902 1.00 43.29  ? 267 ARG A CA  1 
ATOM   1671 C C   . ARG A 1 267 ? -32.908 -26.862 -15.905 1.00 41.16  ? 267 ARG A C   1 
ATOM   1672 O O   . ARG A 1 267 ? -31.726 -26.552 -16.091 1.00 41.69  ? 267 ARG A O   1 
ATOM   1673 C CB  . ARG A 1 267 ? -33.755 -28.731 -17.310 1.00 40.83  ? 267 ARG A CB  1 
ATOM   1674 C CG  . ARG A 1 267 ? -32.599 -28.688 -18.288 1.00 45.13  ? 267 ARG A CG  1 
ATOM   1675 C CD  . ARG A 1 267 ? -33.007 -28.804 -19.745 1.00 49.57  ? 267 ARG A CD  1 
ATOM   1676 N NE  . ARG A 1 267 ? -33.560 -30.125 -20.018 1.00 57.16  ? 267 ARG A NE  1 
ATOM   1677 C CZ  . ARG A 1 267 ? -34.864 -30.376 -20.164 1.00 60.41  ? 267 ARG A CZ  1 
ATOM   1678 N NH1 . ARG A 1 267 ? -35.759 -29.373 -20.117 1.00 46.13  ? 267 ARG A NH1 1 
ATOM   1679 N NH2 . ARG A 1 267 ? -35.274 -31.630 -20.389 1.00 56.29  ? 267 ARG A NH2 1 
ATOM   1680 N N   . TYR A 1 268 ? -33.862 -25.950 -15.716 1.00 38.68  ? 268 TYR A N   1 
ATOM   1681 C CA  . TYR A 1 268 ? -33.515 -24.553 -15.499 1.00 40.81  ? 268 TYR A CA  1 
ATOM   1682 C C   . TYR A 1 268 ? -32.727 -24.378 -14.210 1.00 42.83  ? 268 TYR A C   1 
ATOM   1683 O O   . TYR A 1 268 ? -31.705 -23.680 -14.183 1.00 43.55  ? 268 TYR A O   1 
ATOM   1684 C CB  . TYR A 1 268 ? -34.772 -23.717 -15.441 1.00 44.73  ? 268 TYR A CB  1 
ATOM   1685 C CG  . TYR A 1 268 ? -34.559 -22.256 -15.122 1.00 40.66  ? 268 TYR A CG  1 
ATOM   1686 C CD1 . TYR A 1 268 ? -34.349 -21.344 -16.139 1.00 40.93  ? 268 TYR A CD1 1 
ATOM   1687 C CD2 . TYR A 1 268 ? -34.608 -21.788 -13.816 1.00 38.22  ? 268 TYR A CD2 1 
ATOM   1688 C CE1 . TYR A 1 268 ? -34.188 -20.008 -15.887 1.00 46.52  ? 268 TYR A CE1 1 
ATOM   1689 C CE2 . TYR A 1 268 ? -34.453 -20.440 -13.543 1.00 43.80  ? 268 TYR A CE2 1 
ATOM   1690 C CZ  . TYR A 1 268 ? -34.241 -19.544 -14.594 1.00 46.92  ? 268 TYR A CZ  1 
ATOM   1691 O OH  . TYR A 1 268 ? -34.085 -18.182 -14.380 1.00 38.26  ? 268 TYR A OH  1 
ATOM   1692 N N   . ARG A 1 269 ? -33.190 -25.000 -13.125 1.00 35.00  ? 269 ARG A N   1 
ATOM   1693 C CA  . ARG A 1 269 ? -32.522 -24.806 -11.845 1.00 33.44  ? 269 ARG A CA  1 
ATOM   1694 C C   . ARG A 1 269 ? -31.142 -25.443 -11.810 1.00 27.67  ? 269 ARG A C   1 
ATOM   1695 O O   . ARG A 1 269 ? -30.251 -24.903 -11.154 1.00 32.98  ? 269 ARG A O   1 
ATOM   1696 C CB  . ARG A 1 269 ? -33.394 -25.336 -10.708 1.00 40.63  ? 269 ARG A CB  1 
ATOM   1697 C CG  . ARG A 1 269 ? -32.842 -25.160 -9.303  1.00 29.36  ? 269 ARG A CG  1 
ATOM   1698 C CD  . ARG A 1 269 ? -33.083 -26.449 -8.573  1.00 34.99  ? 269 ARG A CD  1 
ATOM   1699 N NE  . ARG A 1 269 ? -34.439 -26.522 -8.031  1.00 39.44  ? 269 ARG A NE  1 
ATOM   1700 C CZ  . ARG A 1 269 ? -35.177 -27.631 -7.971  1.00 36.19  ? 269 ARG A CZ  1 
ATOM   1701 N NH1 . ARG A 1 269 ? -34.719 -28.786 -8.433  1.00 38.30  ? 269 ARG A NH1 1 
ATOM   1702 N NH2 . ARG A 1 269 ? -36.380 -27.585 -7.440  1.00 29.41  ? 269 ARG A NH2 1 
ATOM   1703 N N   . ARG A 1 270 ? -30.944 -26.597 -12.468 1.00 30.46  ? 270 ARG A N   1 
ATOM   1704 C CA  . ARG A 1 270 ? -29.605 -27.189 -12.566 1.00 28.72  ? 270 ARG A CA  1 
ATOM   1705 C C   . ARG A 1 270 ? -28.683 -26.305 -13.390 1.00 31.94  ? 270 ARG A C   1 
ATOM   1706 O O   . ARG A 1 270 ? -27.577 -25.943 -12.967 1.00 27.68  ? 270 ARG A O   1 
ATOM   1707 C CB  . ARG A 1 270 ? -29.669 -28.577 -13.208 1.00 29.31  ? 270 ARG A CB  1 
ATOM   1708 C CG  . ARG A 1 270 ? -28.279 -29.316 -13.313 1.00 34.67  ? 270 ARG A CG  1 
ATOM   1709 C CD  . ARG A 1 270 ? -28.296 -30.700 -14.083 1.00 33.04  ? 270 ARG A CD  1 
ATOM   1710 N NE  . ARG A 1 270 ? -29.664 -31.119 -14.375 1.00 34.67  ? 270 ARG A NE  1 
ATOM   1711 C CZ  . ARG A 1 270 ? -30.258 -31.029 -15.566 1.00 41.87  ? 270 ARG A CZ  1 
ATOM   1712 N NH1 . ARG A 1 270 ? -29.601 -30.614 -16.651 1.00 42.01  ? 270 ARG A NH1 1 
ATOM   1713 N NH2 . ARG A 1 270 ? -31.524 -31.383 -15.680 1.00 44.77  ? 270 ARG A NH2 1 
ATOM   1714 N N   . GLU A 1 271 ? -29.125 -25.957 -14.589 1.00 37.20  ? 271 GLU A N   1 
ATOM   1715 C CA  . GLU A 1 271 ? -28.243 -25.266 -15.507 1.00 36.73  ? 271 GLU A CA  1 
ATOM   1716 C C   . GLU A 1 271 ? -27.949 -23.855 -15.021 1.00 34.87  ? 271 GLU A C   1 
ATOM   1717 O O   . GLU A 1 271 ? -26.839 -23.359 -15.220 1.00 37.48  ? 271 GLU A O   1 
ATOM   1718 C CB  . GLU A 1 271 ? -28.875 -25.282 -16.893 1.00 43.72  ? 271 GLU A CB  1 
ATOM   1719 C CG  . GLU A 1 271 ? -28.897 -26.660 -17.497 1.00 42.62  ? 271 GLU A CG  1 
ATOM   1720 C CD  . GLU A 1 271 ? -29.409 -26.666 -18.916 1.00 55.57  ? 271 GLU A CD  1 
ATOM   1721 O OE1 . GLU A 1 271 ? -29.920 -25.624 -19.371 1.00 57.55  ? 271 GLU A OE1 1 
ATOM   1722 O OE2 . GLU A 1 271 ? -29.330 -27.723 -19.570 1.00 63.87  ? 271 GLU A OE2 1 
ATOM   1723 N N   . MET A 1 272 ? -28.913 -23.201 -14.362 1.00 33.76  ? 272 MET A N   1 
ATOM   1724 C CA  . MET A 1 272 ? -28.641 -21.881 -13.797 1.00 33.32  ? 272 MET A CA  1 
ATOM   1725 C C   . MET A 1 272 ? -27.700 -21.973 -12.604 1.00 31.38  ? 272 MET A C   1 
ATOM   1726 O O   . MET A 1 272 ? -26.850 -21.097 -12.420 1.00 31.88  ? 272 MET A O   1 
ATOM   1727 C CB  . MET A 1 272 ? -29.942 -21.177 -13.411 1.00 28.56  ? 272 MET A CB  1 
ATOM   1728 C CG  . MET A 1 272 ? -30.709 -20.803 -14.617 1.00 36.36  ? 272 MET A CG  1 
ATOM   1729 S SD  . MET A 1 272 ? -29.551 -20.271 -15.917 1.00 46.65  ? 272 MET A SD  1 
ATOM   1730 C CE  . MET A 1 272 ? -29.921 -18.529 -15.895 1.00 35.69  ? 272 MET A CE  1 
ATOM   1731 N N   . THR A 1 273 ? -27.835 -23.014 -11.780 1.00 26.82  ? 273 THR A N   1 
ATOM   1732 C CA  . THR A 1 273 ? -26.860 -23.218 -10.730 1.00 25.49  ? 273 THR A CA  1 
ATOM   1733 C C   . THR A 1 273 ? -25.458 -23.386 -11.299 1.00 34.44  ? 273 THR A C   1 
ATOM   1734 O O   . THR A 1 273 ? -24.504 -22.807 -10.773 1.00 36.47  ? 273 THR A O   1 
ATOM   1735 C CB  . THR A 1 273 ? -27.207 -24.429 -9.897  1.00 27.10  ? 273 THR A CB  1 
ATOM   1736 O OG1 . THR A 1 273 ? -28.389 -24.175 -9.142  1.00 25.10  ? 273 THR A OG1 1 
ATOM   1737 C CG2 . THR A 1 273 ? -26.072 -24.705 -8.955  1.00 29.30  ? 273 THR A CG2 1 
ATOM   1738 N N   . LEU A 1 274 ? -25.295 -24.152 -12.385 1.00 36.39  ? 274 LEU A N   1 
ATOM   1739 C CA  . LEU A 1 274 ? -23.928 -24.343 -12.878 1.00 37.50  ? 274 LEU A CA  1 
ATOM   1740 C C   . LEU A 1 274 ? -23.392 -23.110 -13.598 1.00 38.43  ? 274 LEU A C   1 
ATOM   1741 O O   . LEU A 1 274 ? -22.192 -22.833 -13.535 1.00 47.68  ? 274 LEU A O   1 
ATOM   1742 C CB  . LEU A 1 274 ? -23.807 -25.558 -13.792 1.00 32.70  ? 274 LEU A CB  1 
ATOM   1743 C CG  . LEU A 1 274 ? -24.272 -26.876 -13.191 1.00 32.42  ? 274 LEU A CG  1 
ATOM   1744 C CD1 . LEU A 1 274 ? -24.190 -27.926 -14.257 1.00 34.36  ? 274 LEU A CD1 1 
ATOM   1745 C CD2 . LEU A 1 274 ? -23.487 -27.271 -11.941 1.00 37.75  ? 274 LEU A CD2 1 
ATOM   1746 N N   . THR A 1 275 ? -24.229 -22.367 -14.308 1.00 31.34  ? 275 THR A N   1 
ATOM   1747 C CA  . THR A 1 275 ? -23.686 -21.306 -15.139 1.00 36.95  ? 275 THR A CA  1 
ATOM   1748 C C   . THR A 1 275 ? -24.075 -19.912 -14.657 1.00 39.53  ? 275 THR A C   1 
ATOM   1749 O O   . THR A 1 275 ? -23.829 -18.928 -15.372 1.00 39.50  ? 275 THR A O   1 
ATOM   1750 C CB  . THR A 1 275 ? -24.090 -21.527 -16.598 1.00 44.20  ? 275 THR A CB  1 
ATOM   1751 O OG1 . THR A 1 275 ? -25.501 -21.360 -16.754 1.00 47.52  ? 275 THR A OG1 1 
ATOM   1752 C CG2 . THR A 1 275 ? -23.705 -22.944 -17.029 1.00 51.14  ? 275 THR A CG2 1 
ATOM   1753 N N   . VAL A 1 276 ? -24.658 -19.800 -13.456 1.00 36.18  ? 276 VAL A N   1 
ATOM   1754 C CA  . VAL A 1 276 ? -24.900 -18.505 -12.823 1.00 30.49  ? 276 VAL A CA  1 
ATOM   1755 C C   . VAL A 1 276 ? -24.552 -18.541 -11.340 1.00 32.89  ? 276 VAL A C   1 
ATOM   1756 O O   . VAL A 1 276 ? -23.586 -17.898 -10.892 1.00 29.97  ? 276 VAL A O   1 
ATOM   1757 C CB  . VAL A 1 276 ? -26.351 -18.053 -12.997 1.00 26.36  ? 276 VAL A CB  1 
ATOM   1758 C CG1 . VAL A 1 276 ? -26.544 -16.754 -12.305 1.00 31.62  ? 276 VAL A CG1 1 
ATOM   1759 C CG2 . VAL A 1 276 ? -26.641 -17.846 -14.434 1.00 35.61  ? 276 VAL A CG2 1 
ATOM   1760 N N   . LEU A 1 277 ? -25.354 -19.281 -10.570 1.00 29.50  ? 277 LEU A N   1 
ATOM   1761 C CA  . LEU A 1 277 ? -25.276 -19.183 -9.117  1.00 30.21  ? 277 LEU A CA  1 
ATOM   1762 C C   . LEU A 1 277 ? -23.937 -19.659 -8.575  1.00 27.44  ? 277 LEU A C   1 
ATOM   1763 O O   . LEU A 1 277 ? -23.473 -19.150 -7.548  1.00 27.69  ? 277 LEU A O   1 
ATOM   1764 C CB  . LEU A 1 277 ? -26.411 -19.968 -8.466  1.00 30.53  ? 277 LEU A CB  1 
ATOM   1765 C CG  . LEU A 1 277 ? -27.803 -19.565 -8.908  1.00 27.26  ? 277 LEU A CG  1 
ATOM   1766 C CD1 . LEU A 1 277 ? -28.835 -20.274 -8.049  1.00 25.63  ? 277 LEU A CD1 1 
ATOM   1767 C CD2 . LEU A 1 277 ? -27.934 -18.060 -8.866  1.00 26.19  ? 277 LEU A CD2 1 
ATOM   1768 N N   . ASP A 1 278 ? -23.323 -20.647 -9.223  1.00 27.87  ? 278 ASP A N   1 
ATOM   1769 C CA  . ASP A 1 278 ? -21.980 -21.072 -8.836  1.00 28.16  ? 278 ASP A CA  1 
ATOM   1770 C C   . ASP A 1 278 ? -20.956 -20.002 -9.172  1.00 31.28  ? 278 ASP A C   1 
ATOM   1771 O O   . ASP A 1 278 ? -19.955 -19.850 -8.470  1.00 31.60  ? 278 ASP A O   1 
ATOM   1772 C CB  . ASP A 1 278 ? -21.640 -22.393 -9.534  1.00 35.69  ? 278 ASP A CB  1 
ATOM   1773 C CG  . ASP A 1 278 ? -22.419 -23.599 -8.953  1.00 39.72  ? 278 ASP A CG  1 
ATOM   1774 O OD1 . ASP A 1 278 ? -22.977 -23.485 -7.813  1.00 33.39  ? 278 ASP A OD1 1 
ATOM   1775 O OD2 . ASP A 1 278 ? -22.550 -24.617 -9.702  1.00 37.36  ? 278 ASP A OD2 1 
ATOM   1776 N N   . LEU A 1 279 ? -21.218 -19.218 -10.215 1.00 36.01  ? 279 LEU A N   1 
ATOM   1777 C CA  . LEU A 1 279 ? -20.279 -18.188 -10.619 1.00 27.21  ? 279 LEU A CA  1 
ATOM   1778 C C   . LEU A 1 279 ? -20.342 -17.005 -9.657  1.00 30.66  ? 279 LEU A C   1 
ATOM   1779 O O   . LEU A 1 279 ? -19.313 -16.603 -9.098  1.00 29.57  ? 279 LEU A O   1 
ATOM   1780 C CB  . LEU A 1 279 ? -20.576 -17.801 -12.064 1.00 27.34  ? 279 LEU A CB  1 
ATOM   1781 C CG  . LEU A 1 279 ? -19.564 -17.051 -12.925 1.00 33.99  ? 279 LEU A CG  1 
ATOM   1782 C CD1 . LEU A 1 279 ? -18.274 -17.848 -13.060 1.00 31.36  ? 279 LEU A CD1 1 
ATOM   1783 C CD2 . LEU A 1 279 ? -20.189 -16.741 -14.304 1.00 32.23  ? 279 LEU A CD2 1 
ATOM   1784 N N   . ILE A 1 280 ? -21.551 -16.479 -9.386  1.00 29.36  ? 280 ILE A N   1 
ATOM   1785 C CA  . ILE A 1 280 ? -21.660 -15.361 -8.438  1.00 29.36  ? 280 ILE A CA  1 
ATOM   1786 C C   . ILE A 1 280 ? -21.110 -15.731 -7.072  1.00 25.61  ? 280 ILE A C   1 
ATOM   1787 O O   . ILE A 1 280 ? -20.645 -14.863 -6.337  1.00 23.96  ? 280 ILE A O   1 
ATOM   1788 C CB  . ILE A 1 280 ? -23.108 -14.866 -8.275  1.00 28.39  ? 280 ILE A CB  1 
ATOM   1789 C CG1 . ILE A 1 280 ? -23.947 -15.887 -7.529  1.00 24.44  ? 280 ILE A CG1 1 
ATOM   1790 C CG2 . ILE A 1 280 ? -23.729 -14.542 -9.597  1.00 30.70  ? 280 ILE A CG2 1 
ATOM   1791 C CD1 . ILE A 1 280 ? -25.372 -15.471 -7.449  1.00 26.46  ? 280 ILE A CD1 1 
ATOM   1792 N N   . ALA A 1 281 ? -21.171 -17.010 -6.698  1.00 28.51  ? 281 ALA A N   1 
ATOM   1793 C CA  . ALA A 1 281 ? -20.722 -17.404 -5.369  1.00 26.89  ? 281 ALA A CA  1 
ATOM   1794 C C   . ALA A 1 281 ? -19.278 -17.028 -5.140  1.00 27.13  ? 281 ALA A C   1 
ATOM   1795 O O   . ALA A 1 281 ? -18.874 -16.859 -3.988  1.00 27.81  ? 281 ALA A O   1 
ATOM   1796 C CB  . ALA A 1 281 ? -20.893 -18.908 -5.149  1.00 21.21  ? 281 ALA A CB  1 
ATOM   1797 N N   . LEU A 1 282 ? -18.500 -16.878 -6.206  1.00 24.78  ? 282 LEU A N   1 
ATOM   1798 C CA  . LEU A 1 282 ? -17.086 -16.579 -6.072  1.00 25.39  ? 282 LEU A CA  1 
ATOM   1799 C C   . LEU A 1 282 ? -16.775 -15.088 -6.161  1.00 28.04  ? 282 LEU A C   1 
ATOM   1800 O O   . LEU A 1 282 ? -15.639 -14.694 -5.877  1.00 26.36  ? 282 LEU A O   1 
ATOM   1801 C CB  . LEU A 1 282 ? -16.293 -17.316 -7.155  1.00 31.21  ? 282 LEU A CB  1 
ATOM   1802 C CG  . LEU A 1 282 ? -16.498 -18.806 -7.438  1.00 33.54  ? 282 LEU A CG  1 
ATOM   1803 C CD1 . LEU A 1 282 ? -15.764 -19.173 -8.726  1.00 37.56  ? 282 LEU A CD1 1 
ATOM   1804 C CD2 . LEU A 1 282 ? -16.065 -19.701 -6.265  1.00 33.97  ? 282 LEU A CD2 1 
ATOM   1805 N N   . PHE A 1 283 ? -17.746 -14.261 -6.554  1.00 28.28  ? 283 PHE A N   1 
ATOM   1806 C CA  . PHE A 1 283 ? -17.516 -12.824 -6.703  1.00 25.30  ? 283 PHE A CA  1 
ATOM   1807 C C   . PHE A 1 283 ? -16.872 -12.143 -5.503  1.00 28.79  ? 283 PHE A C   1 
ATOM   1808 O O   . PHE A 1 283 ? -16.045 -11.242 -5.724  1.00 30.56  ? 283 PHE A O   1 
ATOM   1809 C CB  . PHE A 1 283 ? -18.830 -12.107 -7.033  1.00 25.64  ? 283 PHE A CB  1 
ATOM   1810 C CG  . PHE A 1 283 ? -19.319 -12.364 -8.420  1.00 27.96  ? 283 PHE A CG  1 
ATOM   1811 C CD1 . PHE A 1 283 ? -18.534 -13.054 -9.322  1.00 30.74  ? 283 PHE A CD1 1 
ATOM   1812 C CD2 . PHE A 1 283 ? -20.558 -11.924 -8.826  1.00 25.42  ? 283 PHE A CD2 1 
ATOM   1813 C CE1 . PHE A 1 283 ? -18.983 -13.298 -10.605 1.00 31.14  ? 283 PHE A CE1 1 
ATOM   1814 C CE2 . PHE A 1 283 ? -21.014 -12.175 -10.099 1.00 24.49  ? 283 PHE A CE2 1 
ATOM   1815 C CZ  . PHE A 1 283 ? -20.219 -12.853 -10.991 1.00 28.67  ? 283 PHE A CZ  1 
ATOM   1816 N N   . PRO A 1 284 ? -17.181 -12.478 -4.240  1.00 27.74  ? 284 PRO A N   1 
ATOM   1817 C CA  . PRO A 1 284 ? -16.532 -11.740 -3.146  1.00 23.26  ? 284 PRO A CA  1 
ATOM   1818 C C   . PRO A 1 284 ? -15.090 -12.130 -2.911  1.00 21.45  ? 284 PRO A C   1 
ATOM   1819 O O   . PRO A 1 284 ? -14.401 -11.394 -2.209  1.00 23.06  ? 284 PRO A O   1 
ATOM   1820 C CB  . PRO A 1 284 ? -17.414 -12.043 -1.930  1.00 21.56  ? 284 PRO A CB  1 
ATOM   1821 C CG  . PRO A 1 284 ? -18.612 -12.767 -2.474  1.00 21.66  ? 284 PRO A CG  1 
ATOM   1822 C CD  . PRO A 1 284 ? -18.176 -13.421 -3.706  1.00 23.61  ? 284 PRO A CD  1 
ATOM   1823 N N   . LEU A 1 285 ? -14.608 -13.243 -3.476  1.00 28.15  ? 285 LEU A N   1 
ATOM   1824 C CA  . LEU A 1 285 ? -13.202 -13.650 -3.372  1.00 29.70  ? 285 LEU A CA  1 
ATOM   1825 C C   . LEU A 1 285 ? -12.275 -12.915 -4.341  1.00 32.04  ? 285 LEU A C   1 
ATOM   1826 O O   . LEU A 1 285 ? -11.050 -13.039 -4.206  1.00 25.19  ? 285 LEU A O   1 
ATOM   1827 C CB  . LEU A 1 285 ? -13.061 -15.150 -3.611  1.00 26.51  ? 285 LEU A CB  1 
ATOM   1828 C CG  . LEU A 1 285 ? -13.843 -16.057 -2.683  1.00 29.60  ? 285 LEU A CG  1 
ATOM   1829 C CD1 . LEU A 1 285 ? -13.596 -17.531 -3.002  1.00 24.26  ? 285 LEU A CD1 1 
ATOM   1830 C CD2 . LEU A 1 285 ? -13.446 -15.715 -1.248  1.00 28.63  ? 285 LEU A CD2 1 
ATOM   1831 N N   . TYR A 1 286 ? -12.826 -12.182 -5.321  1.00 29.54  ? 286 TYR A N   1 
ATOM   1832 C CA  . TYR A 1 286 ? -12.036 -11.278 -6.139  1.00 25.26  ? 286 TYR A CA  1 
ATOM   1833 C C   . TYR A 1 286 ? -11.597 -10.027 -5.382  1.00 31.70  ? 286 TYR A C   1 
ATOM   1834 O O   . TYR A 1 286 ? -10.744 -9.285  -5.894  1.00 28.57  ? 286 TYR A O   1 
ATOM   1835 C CB  . TYR A 1 286 ? -12.818 -10.860 -7.374  1.00 25.24  ? 286 TYR A CB  1 
ATOM   1836 C CG  . TYR A 1 286 ? -13.286 -11.986 -8.242  1.00 31.50  ? 286 TYR A CG  1 
ATOM   1837 C CD1 . TYR A 1 286 ? -12.720 -13.260 -8.151  1.00 36.96  ? 286 TYR A CD1 1 
ATOM   1838 C CD2 . TYR A 1 286 ? -14.280 -11.778 -9.189  1.00 33.32  ? 286 TYR A CD2 1 
ATOM   1839 C CE1 . TYR A 1 286 ? -13.165 -14.313 -8.968  1.00 38.86  ? 286 TYR A CE1 1 
ATOM   1840 C CE2 . TYR A 1 286 ? -14.731 -12.812 -10.018 1.00 37.40  ? 286 TYR A CE2 1 
ATOM   1841 C CZ  . TYR A 1 286 ? -14.170 -14.077 -9.904  1.00 42.21  ? 286 TYR A CZ  1 
ATOM   1842 O OH  . TYR A 1 286 ? -14.626 -15.092 -10.717 1.00 40.32  ? 286 TYR A OH  1 
ATOM   1843 N N   . ASP A 1 287 ? -12.182 -9.750  -4.205  1.00 28.92  ? 287 ASP A N   1 
ATOM   1844 C CA  . ASP A 1 287 ? -11.694 -8.694  -3.314  1.00 26.11  ? 287 ASP A CA  1 
ATOM   1845 C C   . ASP A 1 287 ? -10.389 -9.138  -2.672  1.00 25.52  ? 287 ASP A C   1 
ATOM   1846 O O   . ASP A 1 287 ? -10.366 -9.721  -1.590  1.00 26.72  ? 287 ASP A O   1 
ATOM   1847 C CB  . ASP A 1 287 ? -12.733 -8.326  -2.262  1.00 26.57  ? 287 ASP A CB  1 
ATOM   1848 C CG  . ASP A 1 287 ? -12.314 -7.106  -1.428  1.00 32.01  ? 287 ASP A CG  1 
ATOM   1849 O OD1 . ASP A 1 287 ? -11.098 -6.783  -1.407  1.00 28.64  ? 287 ASP A OD1 1 
ATOM   1850 O OD2 . ASP A 1 287 ? -13.193 -6.471  -0.786  1.00 33.01  ? 287 ASP A OD2 1 
ATOM   1851 N N   . VAL A 1 288 ? -9.283  -8.805  -3.342  1.00 28.80  ? 288 VAL A N   1 
ATOM   1852 C CA  . VAL A 1 288 ? -7.957  -9.237  -2.921  1.00 31.78  ? 288 VAL A CA  1 
ATOM   1853 C C   . VAL A 1 288 ? -7.441  -8.438  -1.745  1.00 34.26  ? 288 VAL A C   1 
ATOM   1854 O O   . VAL A 1 288 ? -6.404  -8.799  -1.169  1.00 35.93  ? 288 VAL A O   1 
ATOM   1855 C CB  . VAL A 1 288 ? -6.948  -9.137  -4.075  1.00 32.79  ? 288 VAL A CB  1 
ATOM   1856 C CG1 . VAL A 1 288 ? -7.351  -10.080 -5.162  1.00 31.16  ? 288 VAL A CG1 1 
ATOM   1857 C CG2 . VAL A 1 288 ? -6.869  -7.719  -4.580  1.00 27.74  ? 288 VAL A CG2 1 
ATOM   1858 N N   . ARG A 1 289 ? -8.129  -7.360  -1.371  1.00 31.90  ? 289 ARG A N   1 
ATOM   1859 C CA  . ARG A 1 289 ? -7.777  -6.679  -0.129  1.00 32.78  ? 289 ARG A CA  1 
ATOM   1860 C C   . ARG A 1 289 ? -8.298  -7.444  1.076   1.00 29.08  ? 289 ARG A C   1 
ATOM   1861 O O   . ARG A 1 289 ? -7.595  -7.590  2.077   1.00 32.23  ? 289 ARG A O   1 
ATOM   1862 C CB  . ARG A 1 289 ? -8.337  -5.258  -0.116  1.00 35.85  ? 289 ARG A CB  1 
ATOM   1863 C CG  . ARG A 1 289 ? -8.018  -4.494  -1.329  1.00 26.11  ? 289 ARG A CG  1 
ATOM   1864 C CD  . ARG A 1 289 ? -7.824  -3.044  -1.070  1.00 28.52  ? 289 ARG A CD  1 
ATOM   1865 N NE  . ARG A 1 289 ? -6.880  -2.618  -2.087  1.00 33.54  ? 289 ARG A NE  1 
ATOM   1866 C CZ  . ARG A 1 289 ? -5.587  -2.463  -1.869  1.00 27.61  ? 289 ARG A CZ  1 
ATOM   1867 N NH1 . ARG A 1 289 ? -5.111  -2.613  -0.630  1.00 25.44  ? 289 ARG A NH1 1 
ATOM   1868 N NH2 . ARG A 1 289 ? -4.799  -2.126  -2.889  1.00 22.82  ? 289 ARG A NH2 1 
ATOM   1869 N N   . LEU A 1 290 ? -9.540  -7.916  1.012   1.00 26.64  ? 290 LEU A N   1 
ATOM   1870 C CA  . LEU A 1 290 ? -10.026 -8.776  2.086   1.00 31.15  ? 290 LEU A CA  1 
ATOM   1871 C C   . LEU A 1 290 ? -9.465  -10.192 1.999   1.00 31.39  ? 290 LEU A C   1 
ATOM   1872 O O   . LEU A 1 290 ? -9.366  -10.871 3.022   1.00 28.36  ? 290 LEU A O   1 
ATOM   1873 C CB  . LEU A 1 290 ? -11.557 -8.826  2.074   1.00 30.95  ? 290 LEU A CB  1 
ATOM   1874 C CG  . LEU A 1 290 ? -12.347 -7.783  2.841   1.00 24.36  ? 290 LEU A CG  1 
ATOM   1875 C CD1 . LEU A 1 290 ? -13.759 -7.695  2.320   1.00 30.49  ? 290 LEU A CD1 1 
ATOM   1876 C CD2 . LEU A 1 290 ? -12.354 -8.281  4.195   1.00 25.79  ? 290 LEU A CD2 1 
ATOM   1877 N N   . TYR A 1 291 ? -9.119  -10.668 0.800   1.00 31.72  ? 291 TYR A N   1 
ATOM   1878 C CA  . TYR A 1 291 ? -8.540  -11.994 0.619   1.00 31.65  ? 291 TYR A CA  1 
ATOM   1879 C C   . TYR A 1 291 ? -7.160  -11.852 -0.011  1.00 34.43  ? 291 TYR A C   1 
ATOM   1880 O O   . TYR A 1 291 ? -6.999  -12.030 -1.225  1.00 36.64  ? 291 TYR A O   1 
ATOM   1881 C CB  . TYR A 1 291 ? -9.457  -12.860 -0.228  1.00 30.74  ? 291 TYR A CB  1 
ATOM   1882 C CG  . TYR A 1 291 ? -10.791 -13.060 0.427   1.00 34.28  ? 291 TYR A CG  1 
ATOM   1883 C CD1 . TYR A 1 291 ? -10.962 -13.992 1.468   1.00 35.09  ? 291 TYR A CD1 1 
ATOM   1884 C CD2 . TYR A 1 291 ? -11.884 -12.309 0.038   1.00 30.47  ? 291 TYR A CD2 1 
ATOM   1885 C CE1 . TYR A 1 291 ? -12.208 -14.180 2.091   1.00 26.07  ? 291 TYR A CE1 1 
ATOM   1886 C CE2 . TYR A 1 291 ? -13.128 -12.490 0.653   1.00 32.95  ? 291 TYR A CE2 1 
ATOM   1887 C CZ  . TYR A 1 291 ? -13.276 -13.424 1.679   1.00 28.08  ? 291 TYR A CZ  1 
ATOM   1888 O OH  . TYR A 1 291 ? -14.508 -13.566 2.269   1.00 25.52  ? 291 TYR A OH  1 
ATOM   1889 N N   . PRO A 1 292 ? -6.138  -11.543 0.785   1.00 35.22  ? 292 PRO A N   1 
ATOM   1890 C CA  . PRO A 1 292 ? -4.793  -11.297 0.247   1.00 34.90  ? 292 PRO A CA  1 
ATOM   1891 C C   . PRO A 1 292 ? -3.913  -12.533 0.179   1.00 42.07  ? 292 PRO A C   1 
ATOM   1892 O O   . PRO A 1 292 ? -2.694  -12.384 0.090   1.00 45.93  ? 292 PRO A O   1 
ATOM   1893 C CB  . PRO A 1 292 ? -4.202  -10.304 1.256   1.00 32.55  ? 292 PRO A CB  1 
ATOM   1894 C CG  . PRO A 1 292 ? -5.273  -10.095 2.305   1.00 36.96  ? 292 PRO A CG  1 
ATOM   1895 C CD  . PRO A 1 292 ? -6.176  -11.287 2.222   1.00 34.89  ? 292 PRO A CD  1 
ATOM   1896 N N   . LYS A 1 293 ? -4.494  -13.721 0.291   1.00 43.96  ? 293 LYS A N   1 
ATOM   1897 C CA  . LYS A 1 293 ? -3.862  -14.994 -0.012  1.00 41.04  ? 293 LYS A CA  1 
ATOM   1898 C C   . LYS A 1 293 ? -4.770  -15.756 -0.974  1.00 44.98  ? 293 LYS A C   1 
ATOM   1899 O O   . LYS A 1 293 ? -5.813  -15.253 -1.403  1.00 44.49  ? 293 LYS A O   1 
ATOM   1900 C CB  . LYS A 1 293 ? -3.581  -15.812 1.257   1.00 38.06  ? 293 LYS A CB  1 
ATOM   1901 C CG  . LYS A 1 293 ? -3.257  -15.024 2.552   1.00 36.54  ? 293 LYS A CG  1 
ATOM   1902 C CD  . LYS A 1 293 ? -2.198  -15.821 3.369   1.00 45.96  ? 293 LYS A CD  1 
ATOM   1903 C CE  . LYS A 1 293 ? -2.370  -15.785 4.896   1.00 43.40  ? 293 LYS A CE  1 
ATOM   1904 N NZ  . LYS A 1 293 ? -2.466  -14.431 5.507   1.00 46.18  ? 293 LYS A NZ  1 
ATOM   1905 N N   . GLU A 1 294 ? -4.351  -16.966 -1.344  1.00 47.99  ? 294 GLU A N   1 
ATOM   1906 C CA  . GLU A 1 294 ? -5.240  -17.869 -2.062  1.00 46.57  ? 294 GLU A CA  1 
ATOM   1907 C C   . GLU A 1 294 ? -6.284  -18.408 -1.093  1.00 41.30  ? 294 GLU A C   1 
ATOM   1908 O O   . GLU A 1 294 ? -6.017  -18.579 0.100   1.00 41.63  ? 294 GLU A O   1 
ATOM   1909 C CB  . GLU A 1 294 ? -4.437  -19.009 -2.692  1.00 53.05  ? 294 GLU A CB  1 
ATOM   1910 C CG  . GLU A 1 294 ? -4.041  -18.784 -4.146  1.00 68.39  ? 294 GLU A CG  1 
ATOM   1911 C CD  . GLU A 1 294 ? -2.906  -19.699 -4.604  1.00 77.43  ? 294 GLU A CD  1 
ATOM   1912 O OE1 . GLU A 1 294 ? -2.033  -20.024 -3.761  1.00 62.63  ? 294 GLU A OE1 1 
ATOM   1913 O OE2 . GLU A 1 294 ? -2.891  -20.087 -5.802  1.00 81.87  ? 294 GLU A OE2 1 
ATOM   1914 N N   . VAL A 1 295 ? -7.494  -18.649 -1.593  1.00 40.33  ? 295 VAL A N   1 
ATOM   1915 C CA  . VAL A 1 295 ? -8.582  -19.135 -0.752  1.00 35.94  ? 295 VAL A CA  1 
ATOM   1916 C C   . VAL A 1 295 ? -8.905  -20.589 -1.078  1.00 37.25  ? 295 VAL A C   1 
ATOM   1917 O O   . VAL A 1 295 ? -8.962  -20.989 -2.250  1.00 34.82  ? 295 VAL A O   1 
ATOM   1918 C CB  . VAL A 1 295 ? -9.845  -18.267 -0.863  1.00 34.85  ? 295 VAL A CB  1 
ATOM   1919 C CG1 . VAL A 1 295 ? -10.946 -18.890 -0.047  1.00 33.91  ? 295 VAL A CG1 1 
ATOM   1920 C CG2 . VAL A 1 295 ? -9.583  -16.851 -0.355  1.00 34.46  ? 295 VAL A CG2 1 
ATOM   1921 N N   . LYS A 1 296 ? -9.088  -21.380 -0.015  1.00 37.95  ? 296 LYS A N   1 
ATOM   1922 C CA  . LYS A 1 296 ? -9.619  -22.739 -0.077  1.00 35.15  ? 296 LYS A CA  1 
ATOM   1923 C C   . LYS A 1 296 ? -11.105 -22.697 0.253   1.00 27.74  ? 296 LYS A C   1 
ATOM   1924 O O   . LYS A 1 296 ? -11.478 -22.407 1.387   1.00 30.72  ? 296 LYS A O   1 
ATOM   1925 C CB  . LYS A 1 296 ? -8.869  -23.646 0.900   1.00 34.29  ? 296 LYS A CB  1 
ATOM   1926 C CG  . LYS A 1 296 ? -9.297  -25.107 0.865   1.00 24.29  ? 296 LYS A CG  1 
ATOM   1927 C CD  . LYS A 1 296 ? -8.723  -25.863 2.027   1.00 30.02  ? 296 LYS A CD  1 
ATOM   1928 C CE  . LYS A 1 296 ? -9.189  -27.307 2.036   1.00 38.03  ? 296 LYS A CE  1 
ATOM   1929 N NZ  . LYS A 1 296 ? -10.613 -27.421 2.488   1.00 46.88  ? 296 LYS A NZ  1 
ATOM   1930 N N   . THR A 1 297 ? -11.956 -22.997 -0.722  1.00 31.88  ? 297 THR A N   1 
ATOM   1931 C CA  . THR A 1 297 ? -13.391 -22.952 -0.483  1.00 30.41  ? 297 THR A CA  1 
ATOM   1932 C C   . THR A 1 297 ? -14.086 -24.085 -1.242  1.00 31.60  ? 297 THR A C   1 
ATOM   1933 O O   . THR A 1 297 ? -13.446 -24.897 -1.920  1.00 31.94  ? 297 THR A O   1 
ATOM   1934 C CB  . THR A 1 297 ? -13.953 -21.599 -0.893  1.00 32.02  ? 297 THR A CB  1 
ATOM   1935 O OG1 . THR A 1 297 ? -15.346 -21.564 -0.591  1.00 43.56  ? 297 THR A OG1 1 
ATOM   1936 C CG2 . THR A 1 297 ? -13.803 -21.423 -2.374  1.00 31.17  ? 297 THR A CG2 1 
ATOM   1937 N N   . GLU A 1 298 ? -15.413 -24.140 -1.115  1.00 34.73  ? 298 GLU A N   1 
ATOM   1938 C CA  . GLU A 1 298 ? -16.192 -25.178 -1.782  1.00 37.33  ? 298 GLU A CA  1 
ATOM   1939 C C   . GLU A 1 298 ? -17.661 -24.781 -1.934  1.00 33.29  ? 298 GLU A C   1 
ATOM   1940 O O   . GLU A 1 298 ? -18.222 -24.027 -1.136  1.00 26.22  ? 298 GLU A O   1 
ATOM   1941 C CB  . GLU A 1 298 ? -16.132 -26.493 -1.022  1.00 37.20  ? 298 GLU A CB  1 
ATOM   1942 C CG  . GLU A 1 298 ? -16.532 -26.371 0.427   1.00 37.50  ? 298 GLU A CG  1 
ATOM   1943 C CD  . GLU A 1 298 ? -16.061 -27.564 1.214   1.00 46.73  ? 298 GLU A CD  1 
ATOM   1944 O OE1 . GLU A 1 298 ? -14.850 -27.897 1.115   1.00 50.15  ? 298 GLU A OE1 1 
ATOM   1945 O OE2 . GLU A 1 298 ? -16.900 -28.188 1.901   1.00 48.33  ? 298 GLU A OE2 1 
ATOM   1946 N N   . LEU A 1 299 ? -18.278 -25.335 -2.958  1.00 31.79  ? 299 LEU A N   1 
ATOM   1947 C CA  . LEU A 1 299 ? -19.709 -25.225 -3.142  1.00 29.97  ? 299 LEU A CA  1 
ATOM   1948 C C   . LEU A 1 299 ? -20.382 -26.429 -2.480  1.00 33.49  ? 299 LEU A C   1 
ATOM   1949 O O   . LEU A 1 299 ? -20.031 -27.576 -2.775  1.00 39.04  ? 299 LEU A O   1 
ATOM   1950 C CB  . LEU A 1 299 ? -19.986 -25.121 -4.641  1.00 28.76  ? 299 LEU A CB  1 
ATOM   1951 C CG  . LEU A 1 299 ? -19.262 -23.957 -5.361  1.00 29.14  ? 299 LEU A CG  1 
ATOM   1952 C CD1 . LEU A 1 299 ? -19.369 -24.072 -6.860  1.00 34.28  ? 299 LEU A CD1 1 
ATOM   1953 C CD2 . LEU A 1 299 ? -19.829 -22.573 -4.992  1.00 22.76  ? 299 LEU A CD2 1 
ATOM   1954 N N   . THR A 1 300 ? -21.326 -26.175 -1.568  1.00 30.06  ? 300 THR A N   1 
ATOM   1955 C CA  . THR A 1 300 ? -22.010 -27.224 -0.815  1.00 32.00  ? 300 THR A CA  1 
ATOM   1956 C C   . THR A 1 300 ? -23.414 -27.526 -1.331  1.00 36.49  ? 300 THR A C   1 
ATOM   1957 O O   . THR A 1 300 ? -24.104 -28.382 -0.760  1.00 37.63  ? 300 THR A O   1 
ATOM   1958 C CB  . THR A 1 300 ? -22.120 -26.844 0.663   1.00 32.85  ? 300 THR A CB  1 
ATOM   1959 O OG1 . THR A 1 300 ? -22.482 -25.463 0.787   1.00 38.25  ? 300 THR A OG1 1 
ATOM   1960 C CG2 . THR A 1 300 ? -20.799 -27.046 1.340   1.00 35.32  ? 300 THR A CG2 1 
ATOM   1961 N N   . ARG A 1 301 ? -23.874 -26.833 -2.362  1.00 31.50  ? 301 ARG A N   1 
ATOM   1962 C CA  . ARG A 1 301 ? -25.246 -27.036 -2.786  1.00 32.68  ? 301 ARG A CA  1 
ATOM   1963 C C   . ARG A 1 301 ? -25.397 -28.338 -3.578  1.00 37.99  ? 301 ARG A C   1 
ATOM   1964 O O   . ARG A 1 301 ? -24.413 -28.907 -4.063  1.00 33.64  ? 301 ARG A O   1 
ATOM   1965 C CB  . ARG A 1 301 ? -25.726 -25.840 -3.601  1.00 31.65  ? 301 ARG A CB  1 
ATOM   1966 C CG  . ARG A 1 301 ? -25.380 -25.889 -5.075  1.00 28.65  ? 301 ARG A CG  1 
ATOM   1967 C CD  . ARG A 1 301 ? -23.898 -25.887 -5.253  1.00 30.95  ? 301 ARG A CD  1 
ATOM   1968 N NE  . ARG A 1 301 ? -23.498 -26.006 -6.646  1.00 31.72  ? 301 ARG A NE  1 
ATOM   1969 C CZ  . ARG A 1 301 ? -23.252 -27.164 -7.246  1.00 32.10  ? 301 ARG A CZ  1 
ATOM   1970 N NH1 . ARG A 1 301 ? -23.424 -28.292 -6.576  1.00 36.54  ? 301 ARG A NH1 1 
ATOM   1971 N NH2 . ARG A 1 301 ? -22.872 -27.199 -8.516  1.00 32.29  ? 301 ARG A NH2 1 
ATOM   1972 N N   . ASP A 1 302 ? -26.664 -28.812 -3.653  1.00 41.01  ? 302 ASP A N   1 
ATOM   1973 C CA  . ASP A 1 302 ? -27.165 -29.945 -4.431  1.00 29.33  ? 302 ASP A CA  1 
ATOM   1974 C C   . ASP A 1 302 ? -27.557 -29.523 -5.833  1.00 38.69  ? 302 ASP A C   1 
ATOM   1975 O O   . ASP A 1 302 ? -28.061 -28.416 -6.042  1.00 41.39  ? 302 ASP A O   1 
ATOM   1976 C CB  . ASP A 1 302 ? -28.439 -30.525 -3.837  1.00 30.87  ? 302 ASP A CB  1 
ATOM   1977 C CG  . ASP A 1 302 ? -28.276 -31.000 -2.426  1.00 55.65  ? 302 ASP A CG  1 
ATOM   1978 O OD1 . ASP A 1 302 ? -27.112 -31.225 -2.003  1.00 59.80  ? 302 ASP A OD1 1 
ATOM   1979 O OD2 . ASP A 1 302 ? -29.329 -31.148 -1.741  1.00 58.10  ? 302 ASP A OD2 1 
ATOM   1980 N N   . VAL A 1 303 ? -27.415 -30.453 -6.782  1.00 40.01  ? 303 VAL A N   1 
ATOM   1981 C CA  . VAL A 1 303 ? -28.074 -30.377 -8.084  1.00 39.69  ? 303 VAL A CA  1 
ATOM   1982 C C   . VAL A 1 303 ? -28.705 -31.727 -8.380  1.00 38.31  ? 303 VAL A C   1 
ATOM   1983 O O   . VAL A 1 303 ? -28.132 -32.765 -8.032  1.00 39.12  ? 303 VAL A O   1 
ATOM   1984 C CB  . VAL A 1 303 ? -27.106 -29.970 -9.214  1.00 32.34  ? 303 VAL A CB  1 
ATOM   1985 C CG1 . VAL A 1 303 ? -26.771 -28.497 -9.121  1.00 32.25  ? 303 VAL A CG1 1 
ATOM   1986 C CG2 . VAL A 1 303 ? -25.875 -30.763 -9.121  1.00 34.20  ? 303 VAL A CG2 1 
ATOM   1987 N N   . LEU A 1 304 ? -29.891 -31.716 -9.013  1.00 39.78  ? 304 LEU A N   1 
ATOM   1988 C CA  . LEU A 1 304 ? -30.552 -32.939 -9.473  1.00 41.98  ? 304 LEU A CA  1 
ATOM   1989 C C   . LEU A 1 304 ? -30.513 -33.001 -10.997 1.00 40.49  ? 304 LEU A C   1 
ATOM   1990 O O   . LEU A 1 304 ? -31.055 -32.118 -11.670 1.00 40.88  ? 304 LEU A O   1 
ATOM   1991 C CB  . LEU A 1 304 ? -32.006 -33.033 -9.009  1.00 35.87  ? 304 LEU A CB  1 
ATOM   1992 C CG  . LEU A 1 304 ? -32.428 -32.561 -7.629  1.00 37.50  ? 304 LEU A CG  1 
ATOM   1993 C CD1 . LEU A 1 304 ? -33.899 -32.860 -7.386  1.00 35.39  ? 304 LEU A CD1 1 
ATOM   1994 C CD2 . LEU A 1 304 ? -31.591 -33.212 -6.590  1.00 43.27  ? 304 LEU A CD2 1 
ATOM   1995 N N   . THR A 1 305 ? -29.877 -34.047 -11.525 1.00 41.15  ? 305 THR A N   1 
ATOM   1996 C CA  . THR A 1 305 ? -29.987 -34.409 -12.935 1.00 42.10  ? 305 THR A CA  1 
ATOM   1997 C C   . THR A 1 305 ? -31.435 -34.712 -13.326 1.00 43.13  ? 305 THR A C   1 
ATOM   1998 O O   . THR A 1 305 ? -32.240 -35.162 -12.502 1.00 36.01  ? 305 THR A O   1 
ATOM   1999 C CB  . THR A 1 305 ? -29.100 -35.628 -13.202 1.00 37.72  ? 305 THR A CB  1 
ATOM   2000 O OG1 . THR A 1 305 ? -29.319 -36.599 -12.162 1.00 36.24  ? 305 THR A OG1 1 
ATOM   2001 C CG2 . THR A 1 305 ? -27.646 -35.252 -13.271 1.00 37.32  ? 305 THR A CG2 1 
ATOM   2002 N N   . ASP A 1 306 ? -31.761 -34.462 -14.624 1.00 44.02  ? 306 ASP A N   1 
ATOM   2003 C CA  . ASP A 1 306 ? -33.009 -34.876 -15.267 1.00 38.21  ? 306 ASP A CA  1 
ATOM   2004 C C   . ASP A 1 306 ? -33.279 -36.326 -14.908 1.00 44.54  ? 306 ASP A C   1 
ATOM   2005 O O   . ASP A 1 306 ? -32.324 -37.078 -14.647 1.00 46.37  ? 306 ASP A O   1 
ATOM   2006 C CB  . ASP A 1 306 ? -32.963 -34.717 -16.794 1.00 37.90  ? 306 ASP A CB  1 
ATOM   2007 C CG  . ASP A 1 306 ? -33.019 -33.245 -17.250 1.00 50.33  ? 306 ASP A CG  1 
ATOM   2008 O OD1 . ASP A 1 306 ? -33.746 -32.438 -16.598 1.00 49.49  ? 306 ASP A OD1 1 
ATOM   2009 O OD2 . ASP A 1 306 ? -32.350 -32.888 -18.259 1.00 50.23  ? 306 ASP A OD2 1 
ATOM   2010 N N   . PRO A 1 307 ? -34.547 -36.753 -14.852 1.00 43.60  ? 307 PRO A N   1 
ATOM   2011 C CA  . PRO A 1 307 ? -34.855 -38.129 -14.417 1.00 38.05  ? 307 PRO A CA  1 
ATOM   2012 C C   . PRO A 1 307 ? -34.569 -39.141 -15.514 1.00 40.95  ? 307 PRO A C   1 
ATOM   2013 O O   . PRO A 1 307 ? -34.459 -38.803 -16.696 1.00 49.04  ? 307 PRO A O   1 
ATOM   2014 C CB  . PRO A 1 307 ? -36.343 -38.075 -14.086 1.00 34.82  ? 307 PRO A CB  1 
ATOM   2015 C CG  . PRO A 1 307 ? -36.672 -36.594 -14.027 1.00 39.62  ? 307 PRO A CG  1 
ATOM   2016 C CD  . PRO A 1 307 ? -35.766 -35.945 -15.003 1.00 36.63  ? 307 PRO A CD  1 
ATOM   2017 N N   . ILE A 1 308 ? -34.424 -40.400 -15.116 1.00 37.66  ? 308 ILE A N   1 
ATOM   2018 C CA  . ILE A 1 308 ? -34.088 -41.462 -16.063 1.00 42.50  ? 308 ILE A CA  1 
ATOM   2019 C C   . ILE A 1 308 ? -35.364 -42.110 -16.595 1.00 45.43  ? 308 ILE A C   1 
ATOM   2020 O O   . ILE A 1 308 ? -36.102 -42.753 -15.846 1.00 49.27  ? 308 ILE A O   1 
ATOM   2021 C CB  . ILE A 1 308 ? -33.156 -42.499 -15.437 1.00 46.80  ? 308 ILE A CB  1 
ATOM   2022 C CG1 . ILE A 1 308 ? -32.035 -41.792 -14.656 1.00 47.70  ? 308 ILE A CG1 1 
ATOM   2023 C CG2 . ILE A 1 308 ? -32.636 -43.416 -16.536 1.00 54.02  ? 308 ILE A CG2 1 
ATOM   2024 C CD1 . ILE A 1 308 ? -30.926 -42.699 -14.114 1.00 36.05  ? 308 ILE A CD1 1 
ATOM   2025 N N   . VAL A 1 309 ? -35.631 -41.940 -17.895 1.00 43.71  ? 309 VAL A N   1 
ATOM   2026 C CA  . VAL A 1 309 ? -36.875 -42.415 -18.494 1.00 51.17  ? 309 VAL A CA  1 
ATOM   2027 C C   . VAL A 1 309 ? -36.584 -43.183 -19.778 1.00 52.17  ? 309 VAL A C   1 
ATOM   2028 O O   . VAL A 1 309 ? -35.601 -42.924 -20.483 1.00 43.51  ? 309 VAL A O   1 
ATOM   2029 C CB  . VAL A 1 309 ? -37.888 -41.279 -18.780 1.00 46.96  ? 309 VAL A CB  1 
ATOM   2030 C CG1 . VAL A 1 309 ? -38.427 -40.712 -17.488 1.00 40.22  ? 309 VAL A CG1 1 
ATOM   2031 C CG2 . VAL A 1 309 ? -37.259 -40.193 -19.640 1.00 50.89  ? 309 VAL A CG2 1 
ATOM   2032 N N   . GLY A 1 310 ? -37.459 -44.156 -20.063 1.00 52.92  ? 310 GLY A N   1 
ATOM   2033 C CA  . GLY A 1 310 ? -37.367 -44.986 -21.242 1.00 51.89  ? 310 GLY A CA  1 
ATOM   2034 C C   . GLY A 1 310 ? -38.095 -44.445 -22.440 1.00 54.76  ? 310 GLY A C   1 
ATOM   2035 O O   . GLY A 1 310 ? -37.983 -45.029 -23.521 1.00 40.41  ? 310 GLY A O   1 
ATOM   2036 N N   . VAL A 1 311 ? -38.834 -43.337 -22.272 1.00 53.35  ? 311 VAL A N   1 
ATOM   2037 C CA  . VAL A 1 311 ? -39.642 -42.743 -23.330 1.00 50.84  ? 311 VAL A CA  1 
ATOM   2038 C C   . VAL A 1 311 ? -39.478 -41.234 -23.263 1.00 47.95  ? 311 VAL A C   1 
ATOM   2039 O O   . VAL A 1 311 ? -39.273 -40.672 -22.183 1.00 52.13  ? 311 VAL A O   1 
ATOM   2040 C CB  . VAL A 1 311 ? -41.153 -43.092 -23.201 1.00 51.32  ? 311 VAL A CB  1 
ATOM   2041 C CG1 . VAL A 1 311 ? -41.389 -44.594 -23.088 1.00 41.87  ? 311 VAL A CG1 1 
ATOM   2042 C CG2 . VAL A 1 311 ? -41.798 -42.326 -22.062 1.00 53.10  ? 311 VAL A CG2 1 
ATOM   2043 N N   . ASN A 1 312 ? -39.600 -40.573 -24.426 1.00 49.40  ? 312 ASN A N   1 
ATOM   2044 C CA  . ASN A 1 312 ? -39.681 -39.107 -24.456 1.00 50.92  ? 312 ASN A CA  1 
ATOM   2045 C C   . ASN A 1 312 ? -40.978 -38.616 -23.827 1.00 53.36  ? 312 ASN A C   1 
ATOM   2046 O O   . ASN A 1 312 ? -40.957 -37.809 -22.889 1.00 62.68  ? 312 ASN A O   1 
ATOM   2047 C CB  . ASN A 1 312 ? -39.582 -38.576 -25.889 1.00 49.23  ? 312 ASN A CB  1 
ATOM   2048 C CG  . ASN A 1 312 ? -38.215 -38.793 -26.517 1.00 49.59  ? 312 ASN A CG  1 
ATOM   2049 O OD1 . ASN A 1 312 ? -37.189 -38.840 -25.828 1.00 41.54  ? 312 ASN A OD1 1 
ATOM   2050 N ND2 . ASN A 1 312 ? -38.203 -38.950 -27.846 1.00 46.15  ? 312 ASN A ND2 1 
ATOM   2051 N N   . ASN A 1 313 ? -42.118 -39.107 -24.333 1.00 52.70  ? 313 ASN A N   1 
ATOM   2052 C CA  . ASN A 1 313 ? -43.470 -38.675 -23.960 1.00 54.89  ? 313 ASN A CA  1 
ATOM   2053 C C   . ASN A 1 313 ? -44.195 -39.725 -23.117 1.00 57.91  ? 313 ASN A C   1 
ATOM   2054 O O   . ASN A 1 313 ? -44.677 -40.733 -23.647 1.00 57.58  ? 313 ASN A O   1 
ATOM   2055 C CB  . ASN A 1 313 ? -44.278 -38.352 -25.211 1.00 50.32  ? 313 ASN A CB  1 
ATOM   2056 C CG  . ASN A 1 313 ? -45.661 -37.878 -24.896 1.00 53.97  ? 313 ASN A CG  1 
ATOM   2057 O OD1 . ASN A 1 313 ? -46.048 -37.800 -23.725 1.00 61.32  ? 313 ASN A OD1 1 
ATOM   2058 N ND2 . ASN A 1 313 ? -46.432 -37.553 -25.942 1.00 47.61  ? 313 ASN A ND2 1 
ATOM   2059 N N   . LEU A 1 314 ? -44.325 -39.444 -21.818 1.00 63.12  ? 314 LEU A N   1 
ATOM   2060 C CA  . LEU A 1 314 ? -45.009 -40.305 -20.863 1.00 59.67  ? 314 LEU A CA  1 
ATOM   2061 C C   . LEU A 1 314 ? -46.520 -40.152 -20.892 1.00 61.04  ? 314 LEU A C   1 
ATOM   2062 O O   . LEU A 1 314 ? -47.205 -40.774 -20.065 1.00 61.16  ? 314 LEU A O   1 
ATOM   2063 C CB  . LEU A 1 314 ? -44.515 -39.999 -19.461 1.00 55.15  ? 314 LEU A CB  1 
ATOM   2064 C CG  . LEU A 1 314 ? -43.096 -40.428 -19.180 1.00 54.71  ? 314 LEU A CG  1 
ATOM   2065 C CD1 . LEU A 1 314 ? -42.621 -39.541 -18.084 1.00 56.90  ? 314 LEU A CD1 1 
ATOM   2066 C CD2 . LEU A 1 314 ? -43.066 -41.869 -18.725 1.00 50.86  ? 314 LEU A CD2 1 
ATOM   2067 N N   . ARG A 1 315 ? -47.047 -39.335 -21.797 1.00 54.53  ? 315 ARG A N   1 
ATOM   2068 C CA  . ARG A 1 315 ? -48.482 -39.101 -21.894 1.00 61.52  ? 315 ARG A CA  1 
ATOM   2069 C C   . ARG A 1 315 ? -49.100 -38.891 -20.509 1.00 59.40  ? 315 ARG A C   1 
ATOM   2070 O O   . ARG A 1 315 ? -49.961 -39.644 -20.067 1.00 66.04  ? 315 ARG A O   1 
ATOM   2071 C CB  . ARG A 1 315 ? -49.167 -40.258 -22.639 1.00 63.22  ? 315 ARG A CB  1 
ATOM   2072 C CG  . ARG A 1 315 ? -48.929 -40.258 -24.137 1.00 61.00  ? 315 ARG A CG  1 
ATOM   2073 C CD  . ARG A 1 315 ? -49.645 -41.387 -24.821 1.00 61.24  ? 315 ARG A CD  1 
ATOM   2074 N NE  . ARG A 1 315 ? -51.090 -41.230 -24.731 1.00 85.09  ? 315 ARG A NE  1 
ATOM   2075 C CZ  . ARG A 1 315 ? -51.905 -42.087 -24.113 1.00 95.96  ? 315 ARG A CZ  1 
ATOM   2076 N NH1 . ARG A 1 315 ? -51.416 -43.178 -23.524 1.00 87.14  ? 315 ARG A NH1 1 
ATOM   2077 N NH2 . ARG A 1 315 ? -53.217 -41.854 -24.084 1.00 87.01  ? 315 ARG A NH2 1 
ATOM   2078 N N   . GLY A 1 316 ? -48.616 -37.873 -19.806 1.00 62.27  ? 316 GLY A N   1 
ATOM   2079 C CA  . GLY A 1 316 ? -49.205 -37.514 -18.522 1.00 69.60  ? 316 GLY A CA  1 
ATOM   2080 C C   . GLY A 1 316 ? -49.200 -38.552 -17.407 1.00 58.67  ? 316 GLY A C   1 
ATOM   2081 O O   . GLY A 1 316 ? -49.906 -38.392 -16.407 1.00 49.77  ? 316 GLY A O   1 
ATOM   2082 N N   . TYR A 1 317 ? -48.412 -39.613 -17.552 1.00 58.59  ? 317 TYR A N   1 
ATOM   2083 C CA  . TYR A 1 317 ? -48.264 -40.594 -16.489 1.00 56.60  ? 317 TYR A CA  1 
ATOM   2084 C C   . TYR A 1 317 ? -47.071 -40.325 -15.584 1.00 58.57  ? 317 TYR A C   1 
ATOM   2085 O O   . TYR A 1 317 ? -46.864 -41.065 -14.613 1.00 55.93  ? 317 TYR A O   1 
ATOM   2086 C CB  . TYR A 1 317 ? -48.157 -41.999 -17.074 1.00 55.87  ? 317 TYR A CB  1 
ATOM   2087 C CG  . TYR A 1 317 ? -49.469 -42.505 -17.600 1.00 60.99  ? 317 TYR A CG  1 
ATOM   2088 C CD1 . TYR A 1 317 ? -49.868 -42.250 -18.901 1.00 65.61  ? 317 TYR A CD1 1 
ATOM   2089 C CD2 . TYR A 1 317 ? -50.346 -43.177 -16.767 1.00 58.75  ? 317 TYR A CD2 1 
ATOM   2090 C CE1 . TYR A 1 317 ? -51.105 -42.700 -19.375 1.00 73.99  ? 317 TYR A CE1 1 
ATOM   2091 C CE2 . TYR A 1 317 ? -51.575 -43.629 -17.222 1.00 66.22  ? 317 TYR A CE2 1 
ATOM   2092 C CZ  . TYR A 1 317 ? -51.954 -43.395 -18.528 1.00 70.61  ? 317 TYR A CZ  1 
ATOM   2093 O OH  . TYR A 1 317 ? -53.179 -43.848 -18.983 1.00 70.04  ? 317 TYR A OH  1 
ATOM   2094 N N   . GLY A 1 318 ? -46.280 -39.298 -15.877 1.00 59.32  ? 318 GLY A N   1 
ATOM   2095 C CA  . GLY A 1 318 ? -45.215 -38.923 -14.979 1.00 51.04  ? 318 GLY A CA  1 
ATOM   2096 C C   . GLY A 1 318 ? -45.750 -38.387 -13.667 1.00 51.81  ? 318 GLY A C   1 
ATOM   2097 O O   . GLY A 1 318 ? -46.871 -37.881 -13.575 1.00 57.45  ? 318 GLY A O   1 
ATOM   2098 N N   . THR A 1 319 ? -44.928 -38.533 -12.631 1.00 48.32  ? 319 THR A N   1 
ATOM   2099 C CA  . THR A 1 319 ? -45.260 -38.044 -11.301 1.00 49.09  ? 319 THR A CA  1 
ATOM   2100 C C   . THR A 1 319 ? -45.537 -36.551 -11.350 1.00 54.86  ? 319 THR A C   1 
ATOM   2101 O O   . THR A 1 319 ? -44.764 -35.795 -11.949 1.00 57.92  ? 319 THR A O   1 
ATOM   2102 C CB  . THR A 1 319 ? -44.096 -38.314 -10.363 1.00 48.14  ? 319 THR A CB  1 
ATOM   2103 O OG1 . THR A 1 319 ? -43.687 -39.676 -10.518 1.00 52.70  ? 319 THR A OG1 1 
ATOM   2104 C CG2 . THR A 1 319 ? -44.535 -38.115 -8.950  1.00 49.63  ? 319 THR A CG2 1 
ATOM   2105 N N   . THR A 1 320 ? -46.636 -36.118 -10.724 1.00 53.93  ? 320 THR A N   1 
ATOM   2106 C CA  . THR A 1 320 ? -46.998 -34.700 -10.783 1.00 57.55  ? 320 THR A CA  1 
ATOM   2107 C C   . THR A 1 320 ? -45.928 -33.815 -10.133 1.00 56.03  ? 320 THR A C   1 
ATOM   2108 O O   . THR A 1 320 ? -45.148 -34.258 -9.286  1.00 63.50  ? 320 THR A O   1 
ATOM   2109 C CB  . THR A 1 320 ? -48.355 -34.451 -10.117 1.00 61.26  ? 320 THR A CB  1 
ATOM   2110 O OG1 . THR A 1 320 ? -48.254 -34.647 -8.694  1.00 60.93  ? 320 THR A OG1 1 
ATOM   2111 C CG2 . THR A 1 320 ? -49.446 -35.329 -10.734 1.00 62.00  ? 320 THR A CG2 1 
ATOM   2112 N N   . PHE A 1 321 ? -45.908 -32.539 -10.542 1.00 46.90  ? 321 PHE A N   1 
ATOM   2113 C CA  . PHE A 1 321 ? -44.946 -31.570 -10.004 1.00 53.07  ? 321 PHE A CA  1 
ATOM   2114 C C   . PHE A 1 321 ? -44.924 -31.553 -8.473  1.00 58.46  ? 321 PHE A C   1 
ATOM   2115 O O   . PHE A 1 321 ? -43.856 -31.665 -7.850  1.00 53.11  ? 321 PHE A O   1 
ATOM   2116 C CB  . PHE A 1 321 ? -45.286 -30.176 -10.515 1.00 54.85  ? 321 PHE A CB  1 
ATOM   2117 C CG  . PHE A 1 321 ? -44.190 -29.173 -10.337 1.00 49.56  ? 321 PHE A CG  1 
ATOM   2118 C CD1 . PHE A 1 321 ? -43.948 -28.603 -9.099  1.00 47.98  ? 321 PHE A CD1 1 
ATOM   2119 C CD2 . PHE A 1 321 ? -43.466 -28.734 -11.433 1.00 47.54  ? 321 PHE A CD2 1 
ATOM   2120 C CE1 . PHE A 1 321 ? -42.966 -27.663 -8.942  1.00 41.83  ? 321 PHE A CE1 1 
ATOM   2121 C CE2 . PHE A 1 321 ? -42.494 -27.791 -11.286 1.00 44.51  ? 321 PHE A CE2 1 
ATOM   2122 C CZ  . PHE A 1 321 ? -42.244 -27.253 -10.030 1.00 41.74  ? 321 PHE A CZ  1 
ATOM   2123 N N   . SER A 1 322 ? -46.098 -31.364 -7.851  1.00 58.32  ? 322 SER A N   1 
ATOM   2124 C CA  . SER A 1 322 ? -46.186 -31.382 -6.392  1.00 53.86  ? 322 SER A CA  1 
ATOM   2125 C C   . SER A 1 322 ? -45.581 -32.644 -5.806  1.00 50.76  ? 322 SER A C   1 
ATOM   2126 O O   . SER A 1 322 ? -45.024 -32.614 -4.704  1.00 51.87  ? 322 SER A O   1 
ATOM   2127 C CB  . SER A 1 322 ? -47.641 -31.267 -5.945  1.00 55.36  ? 322 SER A CB  1 
ATOM   2128 O OG  . SER A 1 322 ? -48.204 -30.060 -6.417  1.00 72.85  ? 322 SER A OG  1 
ATOM   2129 N N   . ASN A 1 323 ? -45.678 -33.758 -6.521  1.00 49.67  ? 323 ASN A N   1 
ATOM   2130 C CA  . ASN A 1 323 ? -45.289 -35.032 -5.939  1.00 54.15  ? 323 ASN A CA  1 
ATOM   2131 C C   . ASN A 1 323 ? -43.804 -35.291 -6.010  1.00 51.23  ? 323 ASN A C   1 
ATOM   2132 O O   . ASN A 1 323 ? -43.340 -36.233 -5.363  1.00 48.45  ? 323 ASN A O   1 
ATOM   2133 C CB  . ASN A 1 323 ? -46.033 -36.172 -6.619  1.00 55.29  ? 323 ASN A CB  1 
ATOM   2134 C CG  . ASN A 1 323 ? -47.459 -36.250 -6.191  1.00 57.19  ? 323 ASN A CG  1 
ATOM   2135 O OD1 . ASN A 1 323 ? -48.361 -36.254 -7.028  1.00 58.03  ? 323 ASN A OD1 1 
ATOM   2136 N ND2 . ASN A 1 323 ? -47.683 -36.343 -4.873  1.00 56.93  ? 323 ASN A ND2 1 
ATOM   2137 N N   . ILE A 1 324 ? -43.058 -34.492 -6.773  1.00 50.39  ? 324 ILE A N   1 
ATOM   2138 C CA  . ILE A 1 324 ? -41.607 -34.617 -6.828  1.00 46.58  ? 324 ILE A CA  1 
ATOM   2139 C C   . ILE A 1 324 ? -40.984 -33.563 -5.924  1.00 50.20  ? 324 ILE A C   1 
ATOM   2140 O O   . ILE A 1 324 ? -40.271 -33.893 -4.962  1.00 44.28  ? 324 ILE A O   1 
ATOM   2141 C CB  . ILE A 1 324 ? -41.096 -34.462 -8.263  1.00 44.11  ? 324 ILE A CB  1 
ATOM   2142 C CG1 . ILE A 1 324 ? -41.682 -35.562 -9.145  1.00 48.77  ? 324 ILE A CG1 1 
ATOM   2143 C CG2 . ILE A 1 324 ? -39.585 -34.482 -8.262  1.00 44.19  ? 324 ILE A CG2 1 
ATOM   2144 C CD1 . ILE A 1 324 ? -41.407 -35.387 -10.622 1.00 42.90  ? 324 ILE A CD1 1 
ATOM   2145 N N   . GLU A 1 325 ? -41.293 -32.289 -6.210  1.00 44.23  ? 325 GLU A N   1 
ATOM   2146 C CA  . GLU A 1 325 ? -40.618 -31.178 -5.545  1.00 42.63  ? 325 GLU A CA  1 
ATOM   2147 C C   . GLU A 1 325 ? -40.923 -31.134 -4.049  1.00 45.77  ? 325 GLU A C   1 
ATOM   2148 O O   . GLU A 1 325 ? -40.041 -30.818 -3.237  1.00 44.07  ? 325 GLU A O   1 
ATOM   2149 C CB  . GLU A 1 325 ? -41.012 -29.869 -6.215  1.00 40.73  ? 325 GLU A CB  1 
ATOM   2150 C CG  . GLU A 1 325 ? -40.288 -28.633 -5.711  1.00 42.75  ? 325 GLU A CG  1 
ATOM   2151 C CD  . GLU A 1 325 ? -38.860 -28.504 -6.219  1.00 43.51  ? 325 GLU A CD  1 
ATOM   2152 O OE1 . GLU A 1 325 ? -38.306 -29.476 -6.792  1.00 42.49  ? 325 GLU A OE1 1 
ATOM   2153 O OE2 . GLU A 1 325 ? -38.296 -27.391 -6.080  1.00 43.81  ? 325 GLU A OE2 1 
ATOM   2154 N N   . ASN A 1 326 ? -42.158 -31.448 -3.655  1.00 42.98  ? 326 ASN A N   1 
ATOM   2155 C CA  . ASN A 1 326 ? -42.397 -31.394 -2.223  1.00 44.23  ? 326 ASN A CA  1 
ATOM   2156 C C   . ASN A 1 326 ? -41.752 -32.539 -1.492  1.00 46.76  ? 326 ASN A C   1 
ATOM   2157 O O   . ASN A 1 326 ? -41.875 -32.604 -0.263  1.00 46.78  ? 326 ASN A O   1 
ATOM   2158 C CB  . ASN A 1 326 ? -43.890 -31.369 -1.905  1.00 44.11  ? 326 ASN A CB  1 
ATOM   2159 C CG  . ASN A 1 326 ? -44.567 -30.116 -2.415  1.00 46.56  ? 326 ASN A CG  1 
ATOM   2160 O OD1 . ASN A 1 326 ? -45.537 -30.185 -3.158  1.00 51.09  ? 326 ASN A OD1 1 
ATOM   2161 N ND2 . ASN A 1 326 ? -44.013 -28.959 -2.071  1.00 47.55  ? 326 ASN A ND2 1 
ATOM   2162 N N   . TYR A 1 327 ? -41.073 -33.434 -2.215  1.00 42.21  ? 327 TYR A N   1 
ATOM   2163 C CA  . TYR A 1 327 ? -40.549 -34.657 -1.629  1.00 43.63  ? 327 TYR A CA  1 
ATOM   2164 C C   . TYR A 1 327 ? -39.072 -34.892 -1.938  1.00 44.86  ? 327 TYR A C   1 
ATOM   2165 O O   . TYR A 1 327 ? -38.541 -35.958 -1.616  1.00 41.48  ? 327 TYR A O   1 
ATOM   2166 C CB  . TYR A 1 327 ? -41.399 -35.857 -2.070  1.00 46.84  ? 327 TYR A CB  1 
ATOM   2167 C CG  . TYR A 1 327 ? -42.842 -35.870 -1.561  1.00 47.35  ? 327 TYR A CG  1 
ATOM   2168 C CD1 . TYR A 1 327 ? -43.832 -35.073 -2.135  1.00 55.11  ? 327 TYR A CD1 1 
ATOM   2169 C CD2 . TYR A 1 327 ? -43.220 -36.728 -0.545  1.00 51.96  ? 327 TYR A CD2 1 
ATOM   2170 C CE1 . TYR A 1 327 ? -45.164 -35.104 -1.662  1.00 64.96  ? 327 TYR A CE1 1 
ATOM   2171 C CE2 . TYR A 1 327 ? -44.540 -36.780 -0.072  1.00 68.70  ? 327 TYR A CE2 1 
ATOM   2172 C CZ  . TYR A 1 327 ? -45.515 -35.969 -0.623  1.00 75.45  ? 327 TYR A CZ  1 
ATOM   2173 O OH  . TYR A 1 327 ? -46.824 -36.038 -0.137  1.00 68.95  ? 327 TYR A OH  1 
ATOM   2174 N N   . ILE A 1 328 ? -38.378 -33.924 -2.518  1.00 48.36  ? 328 ILE A N   1 
ATOM   2175 C CA  . ILE A 1 328 ? -36.936 -34.045 -2.681  1.00 41.07  ? 328 ILE A CA  1 
ATOM   2176 C C   . ILE A 1 328 ? -36.241 -33.467 -1.462  1.00 41.02  ? 328 ILE A C   1 
ATOM   2177 O O   . ILE A 1 328 ? -36.872 -32.830 -0.617  1.00 49.56  ? 328 ILE A O   1 
ATOM   2178 C CB  . ILE A 1 328 ? -36.470 -33.363 -3.973  1.00 42.37  ? 328 ILE A CB  1 
ATOM   2179 C CG1 . ILE A 1 328 ? -36.668 -31.859 -3.865  1.00 43.10  ? 328 ILE A CG1 1 
ATOM   2180 C CG2 . ILE A 1 328 ? -37.196 -33.932 -5.173  1.00 43.12  ? 328 ILE A CG2 1 
ATOM   2181 C CD1 . ILE A 1 328 ? -36.074 -31.124 -5.034  1.00 44.69  ? 328 ILE A CD1 1 
ATOM   2182 N N   . ARG A 1 329 ? -34.939 -33.697 -1.372  1.00 42.21  ? 329 ARG A N   1 
ATOM   2183 C CA  . ARG A 1 329 ? -34.160 -33.451 -0.167  1.00 42.44  ? 329 ARG A CA  1 
ATOM   2184 C C   . ARG A 1 329 ? -34.313 -32.027 0.319   1.00 49.85  ? 329 ARG A C   1 
ATOM   2185 O O   . ARG A 1 329 ? -33.954 -31.074 -0.386  1.00 55.38  ? 329 ARG A O   1 
ATOM   2186 C CB  . ARG A 1 329 ? -32.696 -33.741 -0.467  1.00 47.83  ? 329 ARG A CB  1 
ATOM   2187 C CG  . ARG A 1 329 ? -32.379 -35.193 -0.593  1.00 39.48  ? 329 ARG A CG  1 
ATOM   2188 C CD  . ARG A 1 329 ? -31.834 -35.653 0.722   1.00 44.29  ? 329 ARG A CD  1 
ATOM   2189 N NE  . ARG A 1 329 ? -30.379 -35.613 0.718   1.00 44.00  ? 329 ARG A NE  1 
ATOM   2190 C CZ  . ARG A 1 329 ? -29.628 -35.888 1.776   1.00 41.65  ? 329 ARG A CZ  1 
ATOM   2191 N NH1 . ARG A 1 329 ? -30.202 -36.216 2.928   1.00 44.47  ? 329 ARG A NH1 1 
ATOM   2192 N NH2 . ARG A 1 329 ? -28.308 -35.863 1.671   1.00 37.60  ? 329 ARG A NH2 1 
ATOM   2193 N N   . LYS A 1 330 ? -34.812 -31.879 1.535   1.00 45.41  ? 330 LYS A N   1 
ATOM   2194 C CA  . LYS A 1 330 ? -34.978 -30.531 2.042   1.00 44.88  ? 330 LYS A CA  1 
ATOM   2195 C C   . LYS A 1 330 ? -33.653 -30.065 2.637   1.00 45.67  ? 330 LYS A C   1 
ATOM   2196 O O   . LYS A 1 330 ? -32.789 -30.893 2.945   1.00 49.58  ? 330 LYS A O   1 
ATOM   2197 C CB  . LYS A 1 330 ? -36.122 -30.527 3.052   1.00 55.28  ? 330 LYS A CB  1 
ATOM   2198 C CG  . LYS A 1 330 ? -37.485 -30.510 2.339   1.00 54.87  ? 330 LYS A CG  1 
ATOM   2199 C CD  . LYS A 1 330 ? -38.694 -30.761 3.228   1.00 53.19  ? 330 LYS A CD  1 
ATOM   2200 C CE  . LYS A 1 330 ? -39.913 -30.212 2.518   1.00 62.55  ? 330 LYS A CE  1 
ATOM   2201 N NZ  . LYS A 1 330 ? -39.959 -30.734 1.098   1.00 55.62  ? 330 LYS A NZ  1 
ATOM   2202 N N   . PRO A 1 331 ? -33.443 -28.737 2.757   1.00 42.92  ? 331 PRO A N   1 
ATOM   2203 C CA  . PRO A 1 331 ? -32.171 -28.216 3.292   1.00 40.68  ? 331 PRO A CA  1 
ATOM   2204 C C   . PRO A 1 331 ? -31.616 -29.045 4.439   1.00 41.53  ? 331 PRO A C   1 
ATOM   2205 O O   . PRO A 1 331 ? -32.240 -29.152 5.498   1.00 38.87  ? 331 PRO A O   1 
ATOM   2206 C CB  . PRO A 1 331 ? -32.547 -26.812 3.775   1.00 36.40  ? 331 PRO A CB  1 
ATOM   2207 C CG  . PRO A 1 331 ? -33.667 -26.400 2.902   1.00 39.40  ? 331 PRO A CG  1 
ATOM   2208 C CD  . PRO A 1 331 ? -34.400 -27.658 2.461   1.00 45.05  ? 331 PRO A CD  1 
ATOM   2209 N N   . HIS A 1 332 ? -30.440 -29.631 4.228   1.00 43.58  ? 332 HIS A N   1 
ATOM   2210 C CA  . HIS A 1 332 ? -29.873 -30.637 5.117   1.00 41.30  ? 332 HIS A CA  1 
ATOM   2211 C C   . HIS A 1 332 ? -28.383 -30.368 5.347   1.00 38.31  ? 332 HIS A C   1 
ATOM   2212 O O   . HIS A 1 332 ? -27.713 -29.748 4.513   1.00 38.56  ? 332 HIS A O   1 
ATOM   2213 C CB  . HIS A 1 332 ? -30.083 -32.026 4.512   1.00 39.56  ? 332 HIS A CB  1 
ATOM   2214 C CG  . HIS A 1 332 ? -29.513 -32.177 3.132   1.00 40.89  ? 332 HIS A CG  1 
ATOM   2215 N ND1 . HIS A 1 332 ? -28.275 -32.737 2.892   1.00 38.84  ? 332 HIS A ND1 1 
ATOM   2216 C CD2 . HIS A 1 332 ? -30.027 -31.874 1.915   1.00 44.64  ? 332 HIS A CD2 1 
ATOM   2217 C CE1 . HIS A 1 332 ? -28.035 -32.748 1.592   1.00 40.62  ? 332 HIS A CE1 1 
ATOM   2218 N NE2 . HIS A 1 332 ? -29.088 -32.240 0.975   1.00 51.12  ? 332 HIS A NE2 1 
ATOM   2219 N N   . LEU A 1 333 ? -27.861 -30.838 6.490   1.00 33.33  ? 333 LEU A N   1 
ATOM   2220 C CA  . LEU A 1 333 ? -26.410 -30.878 6.685   1.00 35.31  ? 333 LEU A CA  1 
ATOM   2221 C C   . LEU A 1 333 ? -25.754 -31.618 5.533   1.00 37.89  ? 333 LEU A C   1 
ATOM   2222 O O   . LEU A 1 333 ? -26.420 -32.419 4.877   1.00 40.98  ? 333 LEU A O   1 
ATOM   2223 C CB  . LEU A 1 333 ? -26.032 -31.552 7.994   1.00 32.66  ? 333 LEU A CB  1 
ATOM   2224 C CG  . LEU A 1 333 ? -25.647 -30.615 9.124   1.00 38.86  ? 333 LEU A CG  1 
ATOM   2225 C CD1 . LEU A 1 333 ? -26.680 -29.600 9.283   1.00 35.55  ? 333 LEU A CD1 1 
ATOM   2226 C CD2 . LEU A 1 333 ? -25.578 -31.394 10.424  1.00 40.97  ? 333 LEU A CD2 1 
ATOM   2227 N N   . PHE A 1 334 ? -24.472 -31.370 5.266   1.00 34.98  ? 334 PHE A N   1 
ATOM   2228 C CA  . PHE A 1 334 ? -23.824 -32.058 4.160   1.00 28.37  ? 334 PHE A CA  1 
ATOM   2229 C C   . PHE A 1 334 ? -23.586 -33.513 4.541   1.00 33.70  ? 334 PHE A C   1 
ATOM   2230 O O   . PHE A 1 334 ? -23.154 -33.807 5.664   1.00 37.43  ? 334 PHE A O   1 
ATOM   2231 C CB  . PHE A 1 334 ? -22.513 -31.373 3.792   1.00 29.23  ? 334 PHE A CB  1 
ATOM   2232 C CG  . PHE A 1 334 ? -22.093 -31.622 2.386   1.00 34.88  ? 334 PHE A CG  1 
ATOM   2233 C CD1 . PHE A 1 334 ? -21.397 -32.769 2.045   1.00 41.41  ? 334 PHE A CD1 1 
ATOM   2234 C CD2 . PHE A 1 334 ? -22.422 -30.722 1.381   1.00 35.25  ? 334 PHE A CD2 1 
ATOM   2235 C CE1 . PHE A 1 334 ? -21.026 -33.014 0.713   1.00 37.67  ? 334 PHE A CE1 1 
ATOM   2236 C CE2 . PHE A 1 334 ? -22.055 -30.950 0.065   1.00 32.87  ? 334 PHE A CE2 1 
ATOM   2237 C CZ  . PHE A 1 334 ? -21.359 -32.100 -0.267  1.00 36.37  ? 334 PHE A CZ  1 
ATOM   2238 N N   . ASP A 1 335 ? -23.907 -34.431 3.624   1.00 37.39  ? 335 ASP A N   1 
ATOM   2239 C CA  . ASP A 1 335 ? -23.537 -35.834 3.779   1.00 38.99  ? 335 ASP A CA  1 
ATOM   2240 C C   . ASP A 1 335 ? -23.044 -36.403 2.441   1.00 36.67  ? 335 ASP A C   1 
ATOM   2241 O O   . ASP A 1 335 ? -23.113 -35.751 1.394   1.00 34.75  ? 335 ASP A O   1 
ATOM   2242 C CB  . ASP A 1 335 ? -24.698 -36.628 4.391   1.00 37.25  ? 335 ASP A CB  1 
ATOM   2243 C CG  . ASP A 1 335 ? -25.966 -36.542 3.577   1.00 41.55  ? 335 ASP A CG  1 
ATOM   2244 O OD1 . ASP A 1 335 ? -25.895 -36.526 2.320   1.00 44.15  ? 335 ASP A OD1 1 
ATOM   2245 O OD2 . ASP A 1 335 ? -27.049 -36.460 4.208   1.00 39.71  ? 335 ASP A OD2 1 
ATOM   2246 N N   . TYR A 1 336 ? -22.501 -37.620 2.500   1.00 37.29  ? 336 TYR A N   1 
ATOM   2247 C CA  . TYR A 1 336 ? -21.951 -38.333 1.353   1.00 39.32  ? 336 TYR A CA  1 
ATOM   2248 C C   . TYR A 1 336 ? -22.708 -39.643 1.152   1.00 45.92  ? 336 TYR A C   1 
ATOM   2249 O O   . TYR A 1 336 ? -23.180 -40.248 2.122   1.00 48.43  ? 336 TYR A O   1 
ATOM   2250 C CB  . TYR A 1 336 ? -20.466 -38.626 1.564   1.00 40.50  ? 336 TYR A CB  1 
ATOM   2251 C CG  . TYR A 1 336 ? -19.670 -37.409 1.944   1.00 39.88  ? 336 TYR A CG  1 
ATOM   2252 C CD1 . TYR A 1 336 ? -19.680 -36.938 3.247   1.00 39.33  ? 336 TYR A CD1 1 
ATOM   2253 C CD2 . TYR A 1 336 ? -18.897 -36.731 1.003   1.00 42.51  ? 336 TYR A CD2 1 
ATOM   2254 C CE1 . TYR A 1 336 ? -18.971 -35.815 3.601   1.00 41.81  ? 336 TYR A CE1 1 
ATOM   2255 C CE2 . TYR A 1 336 ? -18.177 -35.589 1.353   1.00 40.09  ? 336 TYR A CE2 1 
ATOM   2256 C CZ  . TYR A 1 336 ? -18.224 -35.145 2.655   1.00 39.73  ? 336 TYR A CZ  1 
ATOM   2257 O OH  . TYR A 1 336 ? -17.529 -34.036 3.046   1.00 44.49  ? 336 TYR A OH  1 
ATOM   2258 N N   . LEU A 1 337 ? -22.826 -40.086 -0.111  1.00 47.13  ? 337 LEU A N   1 
ATOM   2259 C CA  . LEU A 1 337 ? -23.545 -41.332 -0.407  1.00 47.56  ? 337 LEU A CA  1 
ATOM   2260 C C   . LEU A 1 337 ? -22.883 -42.504 0.303   1.00 49.50  ? 337 LEU A C   1 
ATOM   2261 O O   . LEU A 1 337 ? -21.674 -42.716 0.154   1.00 50.89  ? 337 LEU A O   1 
ATOM   2262 C CB  . LEU A 1 337 ? -23.535 -41.640 -1.900  1.00 44.45  ? 337 LEU A CB  1 
ATOM   2263 C CG  . LEU A 1 337 ? -24.652 -42.483 -2.524  1.00 39.30  ? 337 LEU A CG  1 
ATOM   2264 C CD1 . LEU A 1 337 ? -24.389 -42.600 -4.020  1.00 37.94  ? 337 LEU A CD1 1 
ATOM   2265 C CD2 . LEU A 1 337 ? -24.953 -43.812 -1.903  1.00 44.92  ? 337 LEU A CD2 1 
ATOM   2266 N N   . HIS A 1 338 ? -23.670 -43.287 1.045   1.00 45.60  ? 338 HIS A N   1 
ATOM   2267 C CA  . HIS A 1 338 ? -23.138 -44.497 1.663   1.00 50.64  ? 338 HIS A CA  1 
ATOM   2268 C C   . HIS A 1 338 ? -23.638 -45.781 1.011   1.00 52.48  ? 338 HIS A C   1 
ATOM   2269 O O   . HIS A 1 338 ? -22.820 -46.632 0.654   1.00 51.27  ? 338 HIS A O   1 
ATOM   2270 C CB  . HIS A 1 338 ? -23.424 -44.519 3.184   1.00 53.10  ? 338 HIS A CB  1 
ATOM   2271 C CG  . HIS A 1 338 ? -22.405 -45.298 3.973   1.00 61.15  ? 338 HIS A CG  1 
ATOM   2272 N ND1 . HIS A 1 338 ? -22.719 -46.430 4.700   1.00 57.77  ? 338 HIS A ND1 1 
ATOM   2273 C CD2 . HIS A 1 338 ? -21.061 -45.137 4.096   1.00 57.73  ? 338 HIS A CD2 1 
ATOM   2274 C CE1 . HIS A 1 338 ? -21.620 -46.912 5.260   1.00 54.95  ? 338 HIS A CE1 1 
ATOM   2275 N NE2 . HIS A 1 338 ? -20.600 -46.153 4.901   1.00 51.66  ? 338 HIS A NE2 1 
ATOM   2276 N N   . ARG A 1 339 ? -24.953 -45.945 0.815   1.00 57.75  ? 339 ARG A N   1 
ATOM   2277 C CA  . ARG A 1 339 ? -25.510 -47.207 0.340   1.00 54.12  ? 339 ARG A CA  1 
ATOM   2278 C C   . ARG A 1 339 ? -26.712 -46.976 -0.577  1.00 49.12  ? 339 ARG A C   1 
ATOM   2279 O O   . ARG A 1 339 ? -27.430 -45.981 -0.460  1.00 51.69  ? 339 ARG A O   1 
ATOM   2280 C CB  . ARG A 1 339 ? -25.897 -48.086 1.546   1.00 56.98  ? 339 ARG A CB  1 
ATOM   2281 C CG  . ARG A 1 339 ? -26.175 -49.544 1.220   1.00 61.65  ? 339 ARG A CG  1 
ATOM   2282 C CD  . ARG A 1 339 ? -25.863 -50.497 2.404   1.00 70.60  ? 339 ARG A CD  1 
ATOM   2283 N NE  . ARG A 1 339 ? -25.876 -49.886 3.751   1.00 75.80  ? 339 ARG A NE  1 
ATOM   2284 C CZ  . ARG A 1 339 ? -24.798 -49.618 4.497   1.00 66.41  ? 339 ARG A CZ  1 
ATOM   2285 N NH1 . ARG A 1 339 ? -23.580 -49.893 4.051   1.00 64.40  ? 339 ARG A NH1 1 
ATOM   2286 N NH2 . ARG A 1 339 ? -24.936 -49.081 5.708   1.00 55.67  ? 339 ARG A NH2 1 
ATOM   2287 N N   . ILE A 1 340 ? -26.906 -47.904 -1.513  1.00 47.16  ? 340 ILE A N   1 
ATOM   2288 C CA  . ILE A 1 340 ? -28.105 -47.995 -2.348  1.00 46.69  ? 340 ILE A CA  1 
ATOM   2289 C C   . ILE A 1 340 ? -28.593 -49.443 -2.322  1.00 51.75  ? 340 ILE A C   1 
ATOM   2290 O O   . ILE A 1 340 ? -27.854 -50.365 -2.693  1.00 51.33  ? 340 ILE A O   1 
ATOM   2291 C CB  . ILE A 1 340 ? -27.861 -47.562 -3.811  1.00 49.59  ? 340 ILE A CB  1 
ATOM   2292 C CG1 . ILE A 1 340 ? -27.143 -46.216 -3.905  1.00 46.66  ? 340 ILE A CG1 1 
ATOM   2293 C CG2 . ILE A 1 340 ? -29.172 -47.507 -4.590  1.00 47.38  ? 340 ILE A CG2 1 
ATOM   2294 C CD1 . ILE A 1 340 ? -26.740 -45.845 -5.287  1.00 38.10  ? 340 ILE A CD1 1 
ATOM   2295 N N   . GLN A 1 341 ? -29.825 -49.645 -1.900  1.00 49.08  ? 341 GLN A N   1 
ATOM   2296 C CA  . GLN A 1 341 ? -30.452 -50.958 -1.946  1.00 51.32  ? 341 GLN A CA  1 
ATOM   2297 C C   . GLN A 1 341 ? -31.415 -50.964 -3.116  1.00 59.10  ? 341 GLN A C   1 
ATOM   2298 O O   . GLN A 1 341 ? -32.526 -50.433 -3.014  1.00 59.97  ? 341 GLN A O   1 
ATOM   2299 C CB  . GLN A 1 341 ? -31.182 -51.261 -0.648  1.00 58.96  ? 341 GLN A CB  1 
ATOM   2300 C CG  . GLN A 1 341 ? -31.794 -52.649 -0.633  1.00 60.88  ? 341 GLN A CG  1 
ATOM   2301 C CD  . GLN A 1 341 ? -32.277 -53.066 0.743   1.00 61.72  ? 341 GLN A CD  1 
ATOM   2302 O OE1 . GLN A 1 341 ? -31.482 -53.236 1.685   1.00 60.63  ? 341 GLN A OE1 1 
ATOM   2303 N NE2 . GLN A 1 341 ? -33.602 -53.180 0.881   1.00 55.27  ? 341 GLN A NE2 1 
ATOM   2304 N N   . PHE A 1 342 ? -30.999 -51.580 -4.222  1.00 57.73  ? 342 PHE A N   1 
ATOM   2305 C CA  . PHE A 1 342 ? -31.851 -51.647 -5.402  1.00 56.61  ? 342 PHE A CA  1 
ATOM   2306 C C   . PHE A 1 342 ? -32.996 -52.652 -5.231  1.00 59.62  ? 342 PHE A C   1 
ATOM   2307 O O   . PHE A 1 342 ? -32.843 -53.704 -4.605  1.00 57.43  ? 342 PHE A O   1 
ATOM   2308 C CB  . PHE A 1 342 ? -31.011 -51.983 -6.627  1.00 47.95  ? 342 PHE A CB  1 
ATOM   2309 C CG  . PHE A 1 342 ? -30.082 -50.890 -7.009  1.00 48.19  ? 342 PHE A CG  1 
ATOM   2310 C CD1 . PHE A 1 342 ? -30.505 -49.865 -7.835  1.00 52.55  ? 342 PHE A CD1 1 
ATOM   2311 C CD2 . PHE A 1 342 ? -28.790 -50.868 -6.530  1.00 49.52  ? 342 PHE A CD2 1 
ATOM   2312 C CE1 . PHE A 1 342 ? -29.642 -48.833 -8.183  1.00 53.74  ? 342 PHE A CE1 1 
ATOM   2313 C CE2 . PHE A 1 342 ? -27.913 -49.848 -6.878  1.00 48.56  ? 342 PHE A CE2 1 
ATOM   2314 C CZ  . PHE A 1 342 ? -28.341 -48.829 -7.699  1.00 50.38  ? 342 PHE A CZ  1 
ATOM   2315 N N   . HIS A 1 343 ? -34.158 -52.295 -5.777  1.00 58.20  ? 343 HIS A N   1 
ATOM   2316 C CA  . HIS A 1 343 ? -35.347 -53.141 -5.806  1.00 55.56  ? 343 HIS A CA  1 
ATOM   2317 C C   . HIS A 1 343 ? -35.833 -53.265 -7.254  1.00 62.18  ? 343 HIS A C   1 
ATOM   2318 O O   . HIS A 1 343 ? -36.274 -52.278 -7.860  1.00 58.54  ? 343 HIS A O   1 
ATOM   2319 C CB  . HIS A 1 343 ? -36.424 -52.563 -4.887  1.00 55.27  ? 343 HIS A CB  1 
ATOM   2320 C CG  . HIS A 1 343 ? -36.150 -52.763 -3.430  1.00 55.96  ? 343 HIS A CG  1 
ATOM   2321 N ND1 . HIS A 1 343 ? -37.049 -53.381 -2.587  1.00 54.05  ? 343 HIS A ND1 1 
ATOM   2322 C CD2 . HIS A 1 343 ? -35.055 -52.496 -2.680  1.00 56.90  ? 343 HIS A CD2 1 
ATOM   2323 C CE1 . HIS A 1 343 ? -36.542 -53.433 -1.369  1.00 53.43  ? 343 HIS A CE1 1 
ATOM   2324 N NE2 . HIS A 1 343 ? -35.330 -52.910 -1.399  1.00 55.19  ? 343 HIS A NE2 1 
ATOM   2325 N N   . THR A 1 344 ? -35.749 -54.483 -7.798  1.00 63.51  ? 344 THR A N   1 
ATOM   2326 C CA  . THR A 1 344 ? -36.163 -54.830 -9.153  1.00 58.16  ? 344 THR A CA  1 
ATOM   2327 C C   . THR A 1 344 ? -37.537 -55.489 -9.184  1.00 60.91  ? 344 THR A C   1 
ATOM   2328 O O   . THR A 1 344 ? -37.841 -56.346 -8.351  1.00 63.93  ? 344 THR A O   1 
ATOM   2329 C CB  . THR A 1 344 ? -35.136 -55.781 -9.772  1.00 56.35  ? 344 THR A CB  1 
ATOM   2330 O OG1 . THR A 1 344 ? -33.938 -55.067 -10.105 1.00 53.48  ? 344 THR A OG1 1 
ATOM   2331 C CG2 . THR A 1 344 ? -35.708 -56.535 -10.963 1.00 63.35  ? 344 THR A CG2 1 
ATOM   2332 N N   . ARG A 1 345 ? -38.360 -55.103 -10.158 1.00 59.22  ? 345 ARG A N   1 
ATOM   2333 C CA  . ARG A 1 345 ? -39.602 -55.807 -10.464 1.00 61.19  ? 345 ARG A CA  1 
ATOM   2334 C C   . ARG A 1 345 ? -39.544 -56.427 -11.860 1.00 63.87  ? 345 ARG A C   1 
ATOM   2335 O O   . ARG A 1 345 ? -38.564 -56.285 -12.601 1.00 60.92  ? 345 ARG A O   1 
ATOM   2336 C CB  . ARG A 1 345 ? -40.819 -54.882 -10.318 1.00 59.94  ? 345 ARG A CB  1 
ATOM   2337 C CG  . ARG A 1 345 ? -41.261 -54.729 -8.886  1.00 60.07  ? 345 ARG A CG  1 
ATOM   2338 C CD  . ARG A 1 345 ? -42.720 -54.364 -8.774  1.00 57.54  ? 345 ARG A CD  1 
ATOM   2339 N NE  . ARG A 1 345 ? -43.102 -54.316 -7.363  1.00 60.00  ? 345 ARG A NE  1 
ATOM   2340 C CZ  . ARG A 1 345 ? -44.330 -54.049 -6.923  1.00 59.61  ? 345 ARG A CZ  1 
ATOM   2341 N NH1 . ARG A 1 345 ? -45.298 -53.781 -7.785  1.00 65.84  ? 345 ARG A NH1 1 
ATOM   2342 N NH2 . ARG A 1 345 ? -44.589 -54.023 -5.621  1.00 57.64  ? 345 ARG A NH2 1 
ATOM   2343 N N   . PHE A 1 346 ? -40.615 -57.144 -12.204 1.00 65.87  ? 346 PHE A N   1 
ATOM   2344 C CA  . PHE A 1 346 ? -40.744 -57.812 -13.492 1.00 64.02  ? 346 PHE A CA  1 
ATOM   2345 C C   . PHE A 1 346 ? -41.834 -57.137 -14.305 1.00 65.16  ? 346 PHE A C   1 
ATOM   2346 O O   . PHE A 1 346 ? -42.946 -56.912 -13.813 1.00 62.90  ? 346 PHE A O   1 
ATOM   2347 C CB  . PHE A 1 346 ? -41.073 -59.294 -13.336 1.00 72.51  ? 346 PHE A CB  1 
ATOM   2348 C CG  . PHE A 1 346 ? -41.352 -59.989 -14.635 1.00 66.25  ? 346 PHE A CG  1 
ATOM   2349 C CD1 . PHE A 1 346 ? -40.410 -60.001 -15.644 1.00 70.41  ? 346 PHE A CD1 1 
ATOM   2350 C CD2 . PHE A 1 346 ? -42.560 -60.624 -14.847 1.00 63.29  ? 346 PHE A CD2 1 
ATOM   2351 C CE1 . PHE A 1 346 ? -40.667 -60.640 -16.849 1.00 72.75  ? 346 PHE A CE1 1 
ATOM   2352 C CE2 . PHE A 1 346 ? -42.826 -61.254 -16.042 1.00 61.80  ? 346 PHE A CE2 1 
ATOM   2353 C CZ  . PHE A 1 346 ? -41.880 -61.266 -17.045 1.00 68.87  ? 346 PHE A CZ  1 
ATOM   2354 N N   . GLN A 1 347 ? -41.504 -56.823 -15.550 1.00 69.35  ? 347 GLN A N   1 
ATOM   2355 C CA  . GLN A 1 347 ? -42.392 -56.158 -16.492 1.00 65.11  ? 347 GLN A CA  1 
ATOM   2356 C C   . GLN A 1 347 ? -42.759 -57.160 -17.575 1.00 67.73  ? 347 GLN A C   1 
ATOM   2357 O O   . GLN A 1 347 ? -41.953 -57.414 -18.483 1.00 66.99  ? 347 GLN A O   1 
ATOM   2358 C CB  . GLN A 1 347 ? -41.700 -54.928 -17.087 1.00 64.00  ? 347 GLN A CB  1 
ATOM   2359 C CG  . GLN A 1 347 ? -42.546 -54.099 -18.042 1.00 60.65  ? 347 GLN A CG  1 
ATOM   2360 C CD  . GLN A 1 347 ? -43.992 -54.083 -17.660 1.00 61.38  ? 347 GLN A CD  1 
ATOM   2361 O OE1 . GLN A 1 347 ? -44.357 -53.661 -16.564 1.00 65.52  ? 347 GLN A OE1 1 
ATOM   2362 N NE2 . GLN A 1 347 ? -44.837 -54.540 -18.567 1.00 64.97  ? 347 GLN A NE2 1 
ATOM   2363 N N   . PRO A 1 348 ? -43.931 -57.792 -17.502 1.00 70.49  ? 348 PRO A N   1 
ATOM   2364 C CA  . PRO A 1 348 ? -44.329 -58.732 -18.555 1.00 70.59  ? 348 PRO A CA  1 
ATOM   2365 C C   . PRO A 1 348 ? -44.550 -57.970 -19.846 1.00 81.51  ? 348 PRO A C   1 
ATOM   2366 O O   . PRO A 1 348 ? -45.402 -57.080 -19.906 1.00 83.86  ? 348 PRO A O   1 
ATOM   2367 C CB  . PRO A 1 348 ? -45.636 -59.320 -18.027 1.00 68.01  ? 348 PRO A CB  1 
ATOM   2368 C CG  . PRO A 1 348 ? -46.187 -58.266 -17.174 1.00 69.04  ? 348 PRO A CG  1 
ATOM   2369 C CD  . PRO A 1 348 ? -45.014 -57.577 -16.525 1.00 72.43  ? 348 PRO A CD  1 
ATOM   2370 N N   . GLY A 1 349 ? -43.776 -58.318 -20.876 1.00 86.43  ? 349 GLY A N   1 
ATOM   2371 C CA  . GLY A 1 349 ? -43.844 -57.634 -22.148 1.00 97.58  ? 349 GLY A CA  1 
ATOM   2372 C C   . GLY A 1 349 ? -44.932 -58.181 -23.056 1.00 104.57 ? 349 GLY A C   1 
ATOM   2373 O O   . GLY A 1 349 ? -45.706 -59.066 -22.696 1.00 105.51 ? 349 GLY A O   1 
ATOM   2374 N N   . TYR A 1 350 ? -44.991 -57.628 -24.266 1.00 110.44 ? 350 TYR A N   1 
ATOM   2375 C CA  . TYR A 1 350 ? -46.026 -58.043 -25.197 1.00 122.83 ? 350 TYR A CA  1 
ATOM   2376 C C   . TYR A 1 350 ? -45.740 -59.408 -25.802 1.00 133.00 ? 350 TYR A C   1 
ATOM   2377 O O   . TYR A 1 350 ? -46.653 -60.023 -26.363 1.00 138.11 ? 350 TYR A O   1 
ATOM   2378 C CB  . TYR A 1 350 ? -46.176 -56.993 -26.293 1.00 135.65 ? 350 TYR A CB  1 
ATOM   2379 C CG  . TYR A 1 350 ? -47.479 -57.086 -27.028 1.00 157.04 ? 350 TYR A CG  1 
ATOM   2380 C CD1 . TYR A 1 350 ? -48.597 -57.608 -26.408 1.00 159.13 ? 350 TYR A CD1 1 
ATOM   2381 C CD2 . TYR A 1 350 ? -47.601 -56.629 -28.329 1.00 161.10 ? 350 TYR A CD2 1 
ATOM   2382 C CE1 . TYR A 1 350 ? -49.792 -57.689 -27.061 1.00 154.63 ? 350 TYR A CE1 1 
ATOM   2383 C CE2 . TYR A 1 350 ? -48.798 -56.706 -28.993 1.00 158.89 ? 350 TYR A CE2 1 
ATOM   2384 C CZ  . TYR A 1 350 ? -49.892 -57.239 -28.350 1.00 154.34 ? 350 TYR A CZ  1 
ATOM   2385 O OH  . TYR A 1 350 ? -51.096 -57.322 -29.003 1.00 148.52 ? 350 TYR A OH  1 
ATOM   2386 N N   . TYR A 1 351 ? -44.508 -59.895 -25.655 1.00 129.38 ? 351 TYR A N   1 
ATOM   2387 C CA  . TYR A 1 351 ? -44.020 -61.136 -26.242 1.00 131.37 ? 351 TYR A CA  1 
ATOM   2388 C C   . TYR A 1 351 ? -42.873 -61.691 -25.413 1.00 122.63 ? 351 TYR A C   1 
ATOM   2389 O O   . TYR A 1 351 ? -42.266 -60.991 -24.598 1.00 132.09 ? 351 TYR A O   1 
ATOM   2390 C CB  . TYR A 1 351 ? -43.588 -60.923 -27.691 1.00 124.13 ? 351 TYR A CB  1 
ATOM   2391 C CG  . TYR A 1 351 ? -44.729 -61.074 -28.639 1.00 132.26 ? 351 TYR A CG  1 
ATOM   2392 C CD1 . TYR A 1 351 ? -45.212 -62.341 -28.956 1.00 132.76 ? 351 TYR A CD1 1 
ATOM   2393 C CD2 . TYR A 1 351 ? -45.401 -59.966 -29.149 1.00 140.85 ? 351 TYR A CD2 1 
ATOM   2394 C CE1 . TYR A 1 351 ? -46.270 -62.513 -29.821 1.00 131.53 ? 351 TYR A CE1 1 
ATOM   2395 C CE2 . TYR A 1 351 ? -46.487 -60.127 -30.006 1.00 142.15 ? 351 TYR A CE2 1 
ATOM   2396 C CZ  . TYR A 1 351 ? -46.919 -61.408 -30.331 1.00 130.08 ? 351 TYR A CZ  1 
ATOM   2397 O OH  . TYR A 1 351 ? -47.984 -61.586 -31.172 1.00 109.37 ? 351 TYR A OH  1 
ATOM   2398 N N   . GLY A 1 352 ? -42.572 -62.962 -25.645 1.00 124.68 ? 352 GLY A N   1 
ATOM   2399 C CA  . GLY A 1 352 ? -41.541 -63.639 -24.881 1.00 130.59 ? 352 GLY A CA  1 
ATOM   2400 C C   . GLY A 1 352 ? -40.157 -63.083 -25.140 1.00 128.44 ? 352 GLY A C   1 
ATOM   2401 O O   . GLY A 1 352 ? -39.179 -63.839 -25.180 1.00 128.33 ? 352 GLY A O   1 
ATOM   2402 N N   . ASN A 1 353 ? -40.072 -61.761 -25.327 1.00 117.73 ? 353 ASN A N   1 
ATOM   2403 C CA  . ASN A 1 353 ? -38.825 -61.069 -25.625 1.00 110.72 ? 353 ASN A CA  1 
ATOM   2404 C C   . ASN A 1 353 ? -38.745 -59.747 -24.874 1.00 102.84 ? 353 ASN A C   1 
ATOM   2405 O O   . ASN A 1 353 ? -37.799 -59.535 -24.109 1.00 106.02 ? 353 ASN A O   1 
ATOM   2406 C CB  . ASN A 1 353 ? -38.683 -60.823 -27.127 1.00 109.52 ? 353 ASN A CB  1 
ATOM   2407 C CG  . ASN A 1 353 ? -39.162 -61.992 -27.952 1.00 114.93 ? 353 ASN A CG  1 
ATOM   2408 O OD1 . ASN A 1 353 ? -38.581 -63.074 -27.906 1.00 116.82 ? 353 ASN A OD1 1 
ATOM   2409 N ND2 . ASN A 1 353 ? -40.239 -61.785 -28.712 1.00 116.89 ? 353 ASN A ND2 1 
ATOM   2410 N N   . ASP A 1 354 ? -39.724 -58.850 -25.075 1.00 95.68  ? 354 ASP A N   1 
ATOM   2411 C CA  . ASP A 1 354 ? -39.625 -57.527 -24.460 1.00 95.34  ? 354 ASP A CA  1 
ATOM   2412 C C   . ASP A 1 354 ? -39.816 -57.577 -22.944 1.00 91.42  ? 354 ASP A C   1 
ATOM   2413 O O   . ASP A 1 354 ? -39.360 -56.669 -22.246 1.00 87.56  ? 354 ASP A O   1 
ATOM   2414 C CB  . ASP A 1 354 ? -40.623 -56.538 -25.077 1.00 87.65  ? 354 ASP A CB  1 
ATOM   2415 C CG  . ASP A 1 354 ? -41.987 -57.141 -25.309 1.00 92.17  ? 354 ASP A CG  1 
ATOM   2416 O OD1 . ASP A 1 354 ? -42.899 -56.422 -25.761 1.00 87.45  ? 354 ASP A OD1 1 
ATOM   2417 O OD2 . ASP A 1 354 ? -42.141 -58.346 -25.074 1.00 105.97 ? 354 ASP A OD2 1 
ATOM   2418 N N   . SER A 1 355 ? -40.477 -58.609 -22.415 1.00 92.88  ? 355 SER A N   1 
ATOM   2419 C CA  . SER A 1 355 ? -40.609 -58.767 -20.969 1.00 84.79  ? 355 SER A CA  1 
ATOM   2420 C C   . SER A 1 355 ? -39.251 -58.678 -20.292 1.00 84.11  ? 355 SER A C   1 
ATOM   2421 O O   . SER A 1 355 ? -38.329 -59.430 -20.624 1.00 87.17  ? 355 SER A O   1 
ATOM   2422 C CB  . SER A 1 355 ? -41.271 -60.107 -20.639 1.00 90.64  ? 355 SER A CB  1 
ATOM   2423 O OG  . SER A 1 355 ? -42.404 -60.347 -21.457 1.00 98.33  ? 355 SER A OG  1 
ATOM   2424 N N   . PHE A 1 356 ? -39.127 -57.758 -19.335 1.00 77.72  ? 356 PHE A N   1 
ATOM   2425 C CA  . PHE A 1 356 ? -37.831 -57.500 -18.710 1.00 74.10  ? 356 PHE A CA  1 
ATOM   2426 C C   . PHE A 1 356 ? -38.025 -57.209 -17.230 1.00 74.21  ? 356 PHE A C   1 
ATOM   2427 O O   . PHE A 1 356 ? -39.143 -57.217 -16.708 1.00 77.27  ? 356 PHE A O   1 
ATOM   2428 C CB  . PHE A 1 356 ? -37.090 -56.322 -19.352 1.00 68.79  ? 356 PHE A CB  1 
ATOM   2429 C CG  . PHE A 1 356 ? -37.859 -55.005 -19.356 1.00 66.60  ? 356 PHE A CG  1 
ATOM   2430 C CD1 . PHE A 1 356 ? -39.072 -54.842 -19.991 1.00 67.37  ? 356 PHE A CD1 1 
ATOM   2431 C CD2 . PHE A 1 356 ? -37.301 -53.896 -18.741 1.00 69.30  ? 356 PHE A CD2 1 
ATOM   2432 C CE1 . PHE A 1 356 ? -39.741 -53.600 -19.992 1.00 57.36  ? 356 PHE A CE1 1 
ATOM   2433 C CE2 . PHE A 1 356 ? -37.967 -52.662 -18.737 1.00 63.72  ? 356 PHE A CE2 1 
ATOM   2434 C CZ  . PHE A 1 356 ? -39.195 -52.525 -19.362 1.00 52.78  ? 356 PHE A CZ  1 
ATOM   2435 N N   . ASN A 1 357 ? -36.911 -56.915 -16.570 1.00 74.05  ? 357 ASN A N   1 
ATOM   2436 C CA  . ASN A 1 357 ? -36.869 -56.528 -15.170 1.00 67.76  ? 357 ASN A CA  1 
ATOM   2437 C C   . ASN A 1 357 ? -36.565 -55.039 -15.100 1.00 63.31  ? 357 ASN A C   1 
ATOM   2438 O O   . ASN A 1 357 ? -35.822 -54.506 -15.934 1.00 60.96  ? 357 ASN A O   1 
ATOM   2439 C CB  . ASN A 1 357 ? -35.786 -57.308 -14.417 1.00 68.30  ? 357 ASN A CB  1 
ATOM   2440 C CG  . ASN A 1 357 ? -36.182 -58.726 -14.097 1.00 65.52  ? 357 ASN A CG  1 
ATOM   2441 O OD1 . ASN A 1 357 ? -37.333 -59.112 -14.260 1.00 68.34  ? 357 ASN A OD1 1 
ATOM   2442 N ND2 . ASN A 1 357 ? -35.219 -59.514 -13.641 1.00 64.45  ? 357 ASN A ND2 1 
ATOM   2443 N N   . TYR A 1 358 ? -37.128 -54.357 -14.117 1.00 62.94  ? 358 TYR A N   1 
ATOM   2444 C CA  . TYR A 1 358 ? -36.871 -52.929 -14.016 1.00 63.04  ? 358 TYR A CA  1 
ATOM   2445 C C   . TYR A 1 358 ? -36.616 -52.521 -12.570 1.00 61.49  ? 358 TYR A C   1 
ATOM   2446 O O   . TYR A 1 358 ? -37.208 -53.074 -11.638 1.00 59.90  ? 358 TYR A O   1 
ATOM   2447 C CB  . TYR A 1 358 ? -38.013 -52.104 -14.669 1.00 59.39  ? 358 TYR A CB  1 
ATOM   2448 C CG  . TYR A 1 358 ? -39.348 -52.113 -13.964 1.00 54.34  ? 358 TYR A CG  1 
ATOM   2449 C CD1 . TYR A 1 358 ? -40.173 -53.227 -14.016 1.00 56.91  ? 358 TYR A CD1 1 
ATOM   2450 C CD2 . TYR A 1 358 ? -39.782 -51.015 -13.244 1.00 60.69  ? 358 TYR A CD2 1 
ATOM   2451 C CE1 . TYR A 1 358 ? -41.404 -53.243 -13.375 1.00 59.26  ? 358 TYR A CE1 1 
ATOM   2452 C CE2 . TYR A 1 358 ? -41.013 -51.027 -12.589 1.00 66.41  ? 358 TYR A CE2 1 
ATOM   2453 C CZ  . TYR A 1 358 ? -41.814 -52.141 -12.663 1.00 58.27  ? 358 TYR A CZ  1 
ATOM   2454 O OH  . TYR A 1 358 ? -43.021 -52.148 -12.016 1.00 63.79  ? 358 TYR A OH  1 
ATOM   2455 N N   . TRP A 1 359 ? -35.673 -51.589 -12.402 1.00 61.17  ? 359 TRP A N   1 
ATOM   2456 C CA  . TRP A 1 359 ? -35.472 -50.911 -11.131 1.00 56.13  ? 359 TRP A CA  1 
ATOM   2457 C C   . TRP A 1 359 ? -36.751 -50.166 -10.740 1.00 54.65  ? 359 TRP A C   1 
ATOM   2458 O O   . TRP A 1 359 ? -37.217 -49.277 -11.466 1.00 49.89  ? 359 TRP A O   1 
ATOM   2459 C CB  . TRP A 1 359 ? -34.282 -49.964 -11.251 1.00 52.59  ? 359 TRP A CB  1 
ATOM   2460 C CG  . TRP A 1 359 ? -33.935 -49.234 -9.993  1.00 57.64  ? 359 TRP A CG  1 
ATOM   2461 C CD1 . TRP A 1 359 ? -34.383 -49.500 -8.730  1.00 57.80  ? 359 TRP A CD1 1 
ATOM   2462 C CD2 . TRP A 1 359 ? -33.081 -48.091 -9.882  1.00 58.04  ? 359 TRP A CD2 1 
ATOM   2463 N NE1 . TRP A 1 359 ? -33.845 -48.595 -7.835  1.00 58.38  ? 359 TRP A NE1 1 
ATOM   2464 C CE2 . TRP A 1 359 ? -33.045 -47.721 -8.519  1.00 52.23  ? 359 TRP A CE2 1 
ATOM   2465 C CE3 . TRP A 1 359 ? -32.339 -47.348 -10.804 1.00 54.40  ? 359 TRP A CE3 1 
ATOM   2466 C CZ2 . TRP A 1 359 ? -32.301 -46.649 -8.059  1.00 49.65  ? 359 TRP A CZ2 1 
ATOM   2467 C CZ3 . TRP A 1 359 ? -31.598 -46.287 -10.345 1.00 55.90  ? 359 TRP A CZ3 1 
ATOM   2468 C CH2 . TRP A 1 359 ? -31.583 -45.945 -8.986  1.00 54.48  ? 359 TRP A CH2 1 
ATOM   2469 N N   . SER A 1 360 ? -37.328 -50.554 -9.600  1.00 55.97  ? 360 SER A N   1 
ATOM   2470 C CA  . SER A 1 360 ? -38.646 -50.098 -9.177  1.00 56.39  ? 360 SER A CA  1 
ATOM   2471 C C   . SER A 1 360 ? -38.631 -49.290 -7.898  1.00 55.04  ? 360 SER A C   1 
ATOM   2472 O O   . SER A 1 360 ? -39.441 -48.364 -7.768  1.00 52.97  ? 360 SER A O   1 
ATOM   2473 C CB  . SER A 1 360 ? -39.588 -51.291 -8.971  1.00 57.52  ? 360 SER A CB  1 
ATOM   2474 O OG  . SER A 1 360 ? -38.948 -52.285 -8.190  1.00 57.14  ? 360 SER A OG  1 
ATOM   2475 N N   . GLY A 1 361 ? -37.750 -49.621 -6.949  1.00 53.30  ? 361 GLY A N   1 
ATOM   2476 C CA  . GLY A 1 361 ? -37.621 -48.882 -5.711  1.00 53.11  ? 361 GLY A CA  1 
ATOM   2477 C C   . GLY A 1 361 ? -36.198 -48.952 -5.193  1.00 52.10  ? 361 GLY A C   1 
ATOM   2478 O O   . GLY A 1 361 ? -35.326 -49.586 -5.793  1.00 47.36  ? 361 GLY A O   1 
ATOM   2479 N N   . ASN A 1 362 ? -35.974 -48.310 -4.044  1.00 56.12  ? 362 ASN A N   1 
ATOM   2480 C CA  . ASN A 1 362 ? -34.651 -48.313 -3.429  1.00 53.10  ? 362 ASN A CA  1 
ATOM   2481 C C   . ASN A 1 362 ? -34.772 -47.795 -2.003  1.00 49.25  ? 362 ASN A C   1 
ATOM   2482 O O   . ASN A 1 362 ? -35.779 -47.188 -1.634  1.00 45.29  ? 362 ASN A O   1 
ATOM   2483 C CB  . ASN A 1 362 ? -33.701 -47.424 -4.217  1.00 51.65  ? 362 ASN A CB  1 
ATOM   2484 C CG  . ASN A 1 362 ? -33.955 -45.968 -3.933  1.00 52.94  ? 362 ASN A CG  1 
ATOM   2485 O OD1 . ASN A 1 362 ? -34.889 -45.349 -4.464  1.00 51.10  ? 362 ASN A OD1 1 
ATOM   2486 N ND2 . ASN A 1 362 ? -33.099 -45.394 -3.114  1.00 52.57  ? 362 ASN A ND2 1 
ATOM   2487 N N   . TYR A 1 363 ? -33.732 -48.051 -1.209  1.00 51.01  ? 363 TYR A N   1 
ATOM   2488 C CA  . TYR A 1 363 ? -33.405 -47.272 -0.020  1.00 52.20  ? 363 TYR A CA  1 
ATOM   2489 C C   . TYR A 1 363 ? -32.146 -46.463 -0.297  1.00 51.87  ? 363 TYR A C   1 
ATOM   2490 O O   . TYR A 1 363 ? -31.364 -46.791 -1.192  1.00 50.94  ? 363 TYR A O   1 
ATOM   2491 C CB  . TYR A 1 363 ? -33.150 -48.151 1.207   1.00 48.81  ? 363 TYR A CB  1 
ATOM   2492 C CG  . TYR A 1 363 ? -34.363 -48.749 1.841   1.00 48.13  ? 363 TYR A CG  1 
ATOM   2493 C CD1 . TYR A 1 363 ? -35.244 -47.967 2.567   1.00 46.38  ? 363 TYR A CD1 1 
ATOM   2494 C CD2 . TYR A 1 363 ? -34.604 -50.118 1.761   1.00 52.91  ? 363 TYR A CD2 1 
ATOM   2495 C CE1 . TYR A 1 363 ? -36.364 -48.530 3.168   1.00 54.38  ? 363 TYR A CE1 1 
ATOM   2496 C CE2 . TYR A 1 363 ? -35.722 -50.700 2.358   1.00 53.05  ? 363 TYR A CE2 1 
ATOM   2497 C CZ  . TYR A 1 363 ? -36.604 -49.901 3.068   1.00 57.02  ? 363 TYR A CZ  1 
ATOM   2498 O OH  . TYR A 1 363 ? -37.714 -50.470 3.688   1.00 56.78  ? 363 TYR A OH  1 
ATOM   2499 N N   . VAL A 1 364 ? -31.928 -45.411 0.492   1.00 55.58  ? 364 VAL A N   1 
ATOM   2500 C CA  . VAL A 1 364 ? -30.684 -44.651 0.401   1.00 57.63  ? 364 VAL A CA  1 
ATOM   2501 C C   . VAL A 1 364 ? -30.107 -44.521 1.799   1.00 55.92  ? 364 VAL A C   1 
ATOM   2502 O O   . VAL A 1 364 ? -30.832 -44.221 2.753   1.00 54.23  ? 364 VAL A O   1 
ATOM   2503 C CB  . VAL A 1 364 ? -30.854 -43.238 -0.193  1.00 50.61  ? 364 VAL A CB  1 
ATOM   2504 C CG1 . VAL A 1 364 ? -29.503 -42.657 -0.479  1.00 51.98  ? 364 VAL A CG1 1 
ATOM   2505 C CG2 . VAL A 1 364 ? -31.665 -43.237 -1.400  1.00 53.61  ? 364 VAL A CG2 1 
ATOM   2506 N N   . SER A 1 365 ? -28.798 -44.720 1.909   1.00 54.18  ? 365 SER A N   1 
ATOM   2507 C CA  . SER A 1 365 ? -28.043 -44.412 3.111   1.00 54.81  ? 365 SER A CA  1 
ATOM   2508 C C   . SER A 1 365 ? -26.987 -43.384 2.740   1.00 52.28  ? 365 SER A C   1 
ATOM   2509 O O   . SER A 1 365 ? -26.433 -43.439 1.641   1.00 51.36  ? 365 SER A O   1 
ATOM   2510 C CB  . SER A 1 365 ? -27.361 -45.656 3.705   1.00 61.72  ? 365 SER A CB  1 
ATOM   2511 O OG  . SER A 1 365 ? -28.261 -46.731 3.902   1.00 63.49  ? 365 SER A OG  1 
ATOM   2512 N N   . THR A 1 366 ? -26.694 -42.455 3.658   1.00 58.53  ? 366 THR A N   1 
ATOM   2513 C CA  . THR A 1 366 ? -25.652 -41.450 3.442   1.00 55.81  ? 366 THR A CA  1 
ATOM   2514 C C   . THR A 1 366 ? -24.838 -41.236 4.718   1.00 52.37  ? 366 THR A C   1 
ATOM   2515 O O   . THR A 1 366 ? -25.393 -41.211 5.825   1.00 47.19  ? 366 THR A O   1 
ATOM   2516 C CB  . THR A 1 366 ? -26.245 -40.107 2.974   1.00 44.49  ? 366 THR A CB  1 
ATOM   2517 O OG1 . THR A 1 366 ? -27.418 -39.798 3.736   1.00 35.69  ? 366 THR A OG1 1 
ATOM   2518 C CG2 . THR A 1 366 ? -26.607 -40.181 1.499   1.00 44.88  ? 366 THR A CG2 1 
ATOM   2519 N N   . ARG A 1 367 ? -23.515 -41.070 4.556   1.00 44.75  ? 367 ARG A N   1 
ATOM   2520 C CA  . ARG A 1 367 ? -22.806 -40.861 5.816   1.00 46.00  ? 367 ARG A CA  1 
ATOM   2521 C C   . ARG A 1 367 ? -22.531 -39.382 6.046   1.00 47.02  ? 367 ARG A C   1 
ATOM   2522 O O   . ARG A 1 367 ? -22.153 -38.666 5.111   1.00 46.12  ? 367 ARG A O   1 
ATOM   2523 C CB  . ARG A 1 367 ? -21.501 -41.666 5.840   1.00 50.42  ? 367 ARG A CB  1 
ATOM   2524 C CG  . ARG A 1 367 ? -20.414 -41.227 4.904   1.00 49.86  ? 367 ARG A CG  1 
ATOM   2525 C CD  . ARG A 1 367 ? -19.014 -41.650 5.380   1.00 54.43  ? 367 ARG A CD  1 
ATOM   2526 N NE  . ARG A 1 367 ? -18.650 -41.108 6.689   1.00 61.41  ? 367 ARG A NE  1 
ATOM   2527 C CZ  . ARG A 1 367 ? -17.524 -41.410 7.339   1.00 61.15  ? 367 ARG A CZ  1 
ATOM   2528 N NH1 . ARG A 1 367 ? -16.627 -42.232 6.780   1.00 40.17  ? 367 ARG A NH1 1 
ATOM   2529 N NH2 . ARG A 1 367 ? -17.292 -40.862 8.539   1.00 60.73  ? 367 ARG A NH2 1 
ATOM   2530 N N   . PRO A 1 368 ? -22.753 -38.904 7.272   1.00 50.12  ? 368 PRO A N   1 
ATOM   2531 C CA  . PRO A 1 368 ? -22.759 -37.458 7.515   1.00 42.58  ? 368 PRO A CA  1 
ATOM   2532 C C   . PRO A 1 368 ? -21.357 -36.877 7.407   1.00 42.07  ? 368 PRO A C   1 
ATOM   2533 O O   . PRO A 1 368 ? -20.364 -37.602 7.365   1.00 46.73  ? 368 PRO A O   1 
ATOM   2534 C CB  . PRO A 1 368 ? -23.312 -37.371 8.937   1.00 40.31  ? 368 PRO A CB  1 
ATOM   2535 C CG  . PRO A 1 368 ? -22.814 -38.592 9.590   1.00 38.66  ? 368 PRO A CG  1 
ATOM   2536 C CD  . PRO A 1 368 ? -22.860 -39.663 8.534   1.00 46.84  ? 368 PRO A CD  1 
ATOM   2537 N N   . SER A 1 369 ? -21.270 -35.547 7.356   1.00 41.00  ? 369 SER A N   1 
ATOM   2538 C CA  . SER A 1 369 ? -19.941 -34.949 7.306   1.00 40.22  ? 369 SER A CA  1 
ATOM   2539 C C   . SER A 1 369 ? -19.128 -35.328 8.545   1.00 43.42  ? 369 SER A C   1 
ATOM   2540 O O   . SER A 1 369 ? -19.666 -35.789 9.569   1.00 40.70  ? 369 SER A O   1 
ATOM   2541 C CB  . SER A 1 369 ? -20.004 -33.434 7.179   1.00 35.36  ? 369 SER A CB  1 
ATOM   2542 O OG  . SER A 1 369 ? -18.794 -32.987 6.592   1.00 38.82  ? 369 SER A OG  1 
ATOM   2543 N N   . ILE A 1 370 ? -17.809 -35.121 8.434   1.00 39.05  ? 370 ILE A N   1 
ATOM   2544 C CA  . ILE A 1 370 ? -16.866 -35.705 9.378   1.00 38.03  ? 370 ILE A CA  1 
ATOM   2545 C C   . ILE A 1 370 ? -17.181 -35.275 10.813  1.00 43.57  ? 370 ILE A C   1 
ATOM   2546 O O   . ILE A 1 370 ? -17.730 -34.193 11.061  1.00 44.77  ? 370 ILE A O   1 
ATOM   2547 C CB  . ILE A 1 370 ? -15.437 -35.314 8.981   1.00 39.32  ? 370 ILE A CB  1 
ATOM   2548 C CG1 . ILE A 1 370 ? -14.420 -36.149 9.749   1.00 34.97  ? 370 ILE A CG1 1 
ATOM   2549 C CG2 . ILE A 1 370 ? -15.232 -33.813 9.191   1.00 40.91  ? 370 ILE A CG2 1 
ATOM   2550 C CD1 . ILE A 1 370 ? -12.983 -35.974 9.264   1.00 34.43  ? 370 ILE A CD1 1 
ATOM   2551 N N   . GLY A 1 371 ? -16.860 -36.153 11.761  1.00 43.29  ? 371 GLY A N   1 
ATOM   2552 C CA  . GLY A 1 371 ? -17.140 -35.927 13.167  1.00 46.61  ? 371 GLY A CA  1 
ATOM   2553 C C   . GLY A 1 371 ? -18.165 -36.882 13.751  1.00 49.85  ? 371 GLY A C   1 
ATOM   2554 O O   . GLY A 1 371 ? -18.064 -37.289 14.914  1.00 50.40  ? 371 GLY A O   1 
ATOM   2555 N N   . SER A 1 372 ? -19.188 -37.182 12.952  1.00 50.09  ? 372 SER A N   1 
ATOM   2556 C CA  . SER A 1 372 ? -20.145 -38.253 13.168  1.00 43.49  ? 372 SER A CA  1 
ATOM   2557 C C   . SER A 1 372 ? -19.914 -39.350 12.140  1.00 53.92  ? 372 SER A C   1 
ATOM   2558 O O   . SER A 1 372 ? -19.386 -39.098 11.049  1.00 57.92  ? 372 SER A O   1 
ATOM   2559 C CB  . SER A 1 372 ? -21.577 -37.748 13.038  1.00 44.62  ? 372 SER A CB  1 
ATOM   2560 O OG  . SER A 1 372 ? -22.509 -38.814 13.053  1.00 50.10  ? 372 SER A OG  1 
ATOM   2561 N N   . ASN A 1 373 ? -20.290 -40.582 12.507  1.00 60.03  ? 373 ASN A N   1 
ATOM   2562 C CA  . ASN A 1 373 ? -20.421 -41.672 11.541  1.00 52.80  ? 373 ASN A CA  1 
ATOM   2563 C C   . ASN A 1 373 ? -21.746 -42.411 11.637  1.00 50.22  ? 373 ASN A C   1 
ATOM   2564 O O   . ASN A 1 373 ? -22.020 -43.228 10.757  1.00 50.32  ? 373 ASN A O   1 
ATOM   2565 C CB  . ASN A 1 373 ? -19.291 -42.714 11.682  1.00 42.72  ? 373 ASN A CB  1 
ATOM   2566 C CG  . ASN A 1 373 ? -17.927 -42.093 11.797  1.00 54.25  ? 373 ASN A CG  1 
ATOM   2567 O OD1 . ASN A 1 373 ? -17.233 -41.906 10.798  1.00 58.67  ? 373 ASN A OD1 1 
ATOM   2568 N ND2 . ASN A 1 373 ? -17.514 -41.786 13.031  1.00 58.00  ? 373 ASN A ND2 1 
ATOM   2569 N N   . ASP A 1 374 ? -22.567 -42.182 12.667  1.00 51.41  ? 374 ASP A N   1 
ATOM   2570 C CA  . ASP A 1 374 ? -23.825 -42.921 12.757  1.00 56.30  ? 374 ASP A CA  1 
ATOM   2571 C C   . ASP A 1 374 ? -24.753 -42.478 11.613  1.00 53.16  ? 374 ASP A C   1 
ATOM   2572 O O   . ASP A 1 374 ? -25.241 -41.341 11.572  1.00 61.60  ? 374 ASP A O   1 
ATOM   2573 C CB  . ASP A 1 374 ? -24.439 -42.829 14.167  1.00 59.61  ? 374 ASP A CB  1 
ATOM   2574 C CG  . ASP A 1 374 ? -24.502 -41.414 14.759  1.00 62.95  ? 374 ASP A CG  1 
ATOM   2575 O OD1 . ASP A 1 374 ? -23.488 -40.966 15.354  1.00 57.67  ? 374 ASP A OD1 1 
ATOM   2576 O OD2 . ASP A 1 374 ? -25.587 -40.793 14.736  1.00 69.20  ? 374 ASP A OD2 1 
ATOM   2577 N N   . ILE A 1 375 ? -24.961 -43.402 10.666  1.00 49.80  ? 375 ILE A N   1 
ATOM   2578 C CA  . ILE A 1 375 ? -25.369 -43.138 9.287   1.00 49.87  ? 375 ILE A CA  1 
ATOM   2579 C C   . ILE A 1 375 ? -26.811 -42.638 9.277   1.00 55.05  ? 375 ILE A C   1 
ATOM   2580 O O   . ILE A 1 375 ? -27.457 -42.551 10.327  1.00 62.54  ? 375 ILE A O   1 
ATOM   2581 C CB  . ILE A 1 375 ? -25.204 -44.407 8.411   1.00 44.36  ? 375 ILE A CB  1 
ATOM   2582 C CG1 . ILE A 1 375 ? -23.809 -45.046 8.533   1.00 46.13  ? 375 ILE A CG1 1 
ATOM   2583 C CG2 . ILE A 1 375 ? -25.381 -44.118 6.929   1.00 54.81  ? 375 ILE A CG2 1 
ATOM   2584 C CD1 . ILE A 1 375 ? -22.649 -44.352 7.864   1.00 31.67  ? 375 ILE A CD1 1 
ATOM   2585 N N   . ILE A 1 376 ? -27.308 -42.260 8.102   1.00 57.82  ? 376 ILE A N   1 
ATOM   2586 C CA  . ILE A 1 376 ? -28.713 -41.957 7.879   1.00 55.95  ? 376 ILE A CA  1 
ATOM   2587 C C   . ILE A 1 376 ? -29.208 -42.935 6.824   1.00 60.90  ? 376 ILE A C   1 
ATOM   2588 O O   . ILE A 1 376 ? -28.459 -43.315 5.914   1.00 54.95  ? 376 ILE A O   1 
ATOM   2589 C CB  . ILE A 1 376 ? -28.931 -40.501 7.414   1.00 56.91  ? 376 ILE A CB  1 
ATOM   2590 C CG1 . ILE A 1 376 ? -28.256 -39.510 8.359   1.00 60.60  ? 376 ILE A CG1 1 
ATOM   2591 C CG2 . ILE A 1 376 ? -30.407 -40.173 7.362   1.00 56.72  ? 376 ILE A CG2 1 
ATOM   2592 C CD1 . ILE A 1 376 ? -27.327 -38.529 7.637   1.00 50.15  ? 376 ILE A CD1 1 
ATOM   2593 N N   . THR A 1 377 ? -30.460 -43.365 6.963   1.00 65.02  ? 377 THR A N   1 
ATOM   2594 C CA  . THR A 1 377 ? -31.093 -44.195 5.952   1.00 58.50  ? 377 THR A CA  1 
ATOM   2595 C C   . THR A 1 377 ? -32.506 -43.691 5.725   1.00 51.15  ? 377 THR A C   1 
ATOM   2596 O O   . THR A 1 377 ? -33.209 -43.295 6.663   1.00 52.68  ? 377 THR A O   1 
ATOM   2597 C CB  . THR A 1 377 ? -31.057 -45.686 6.333   1.00 63.90  ? 377 THR A CB  1 
ATOM   2598 O OG1 . THR A 1 377 ? -29.697 -46.057 6.624   1.00 65.66  ? 377 THR A OG1 1 
ATOM   2599 C CG2 . THR A 1 377 ? -31.624 -46.585 5.200   1.00 53.55  ? 377 THR A CG2 1 
ATOM   2600 N N   . SER A 1 378 ? -32.890 -43.692 4.460   1.00 51.17  ? 378 SER A N   1 
ATOM   2601 C CA  . SER A 1 378 ? -34.067 -42.999 3.978   1.00 55.19  ? 378 SER A CA  1 
ATOM   2602 C C   . SER A 1 378 ? -35.321 -43.801 4.285   1.00 54.03  ? 378 SER A C   1 
ATOM   2603 O O   . SER A 1 378 ? -35.255 -44.968 4.684   1.00 55.21  ? 378 SER A O   1 
ATOM   2604 C CB  . SER A 1 378 ? -33.928 -42.779 2.474   1.00 57.40  ? 378 SER A CB  1 
ATOM   2605 O OG  . SER A 1 378 ? -34.116 -44.004 1.779   1.00 59.66  ? 378 SER A OG  1 
ATOM   2606 N N   . PRO A 1 379 ? -36.503 -43.219 4.063   1.00 51.99  ? 379 PRO A N   1 
ATOM   2607 C CA  . PRO A 1 379 ? -37.696 -44.065 3.972   1.00 50.76  ? 379 PRO A CA  1 
ATOM   2608 C C   . PRO A 1 379 ? -37.541 -45.003 2.792   1.00 57.33  ? 379 PRO A C   1 
ATOM   2609 O O   . PRO A 1 379 ? -36.499 -44.989 2.120   1.00 58.13  ? 379 PRO A O   1 
ATOM   2610 C CB  . PRO A 1 379 ? -38.838 -43.066 3.752   1.00 53.71  ? 379 PRO A CB  1 
ATOM   2611 C CG  . PRO A 1 379 ? -38.241 -41.706 3.971   1.00 56.35  ? 379 PRO A CG  1 
ATOM   2612 C CD  . PRO A 1 379 ? -36.794 -41.822 3.694   1.00 50.52  ? 379 PRO A CD  1 
ATOM   2613 N N   . PHE A 1 380 ? -38.541 -45.816 2.495   1.00 52.61  ? 380 PHE A N   1 
ATOM   2614 C CA  . PHE A 1 380 ? -38.494 -46.533 1.236   1.00 51.37  ? 380 PHE A CA  1 
ATOM   2615 C C   . PHE A 1 380 ? -39.064 -45.618 0.165   1.00 46.49  ? 380 PHE A C   1 
ATOM   2616 O O   . PHE A 1 380 ? -40.064 -44.935 0.396   1.00 50.99  ? 380 PHE A O   1 
ATOM   2617 C CB  . PHE A 1 380 ? -39.249 -47.863 1.291   1.00 55.07  ? 380 PHE A CB  1 
ATOM   2618 C CG  . PHE A 1 380 ? -39.055 -48.705 0.059   1.00 54.71  ? 380 PHE A CG  1 
ATOM   2619 C CD1 . PHE A 1 380 ? -37.780 -49.096 -0.333  1.00 51.72  ? 380 PHE A CD1 1 
ATOM   2620 C CD2 . PHE A 1 380 ? -40.136 -49.059 -0.739  1.00 55.21  ? 380 PHE A CD2 1 
ATOM   2621 C CE1 . PHE A 1 380 ? -37.571 -49.840 -1.491  1.00 45.31  ? 380 PHE A CE1 1 
ATOM   2622 C CE2 . PHE A 1 380 ? -39.934 -49.809 -1.898  1.00 55.64  ? 380 PHE A CE2 1 
ATOM   2623 C CZ  . PHE A 1 380 ? -38.640 -50.199 -2.274  1.00 50.35  ? 380 PHE A CZ  1 
ATOM   2624 N N   . TYR A 1 381 ? -38.383 -45.548 -0.972  1.00 44.62  ? 381 TYR A N   1 
ATOM   2625 C CA  . TYR A 1 381 ? -38.901 -44.881 -2.159  1.00 54.63  ? 381 TYR A CA  1 
ATOM   2626 C C   . TYR A 1 381 ? -39.221 -45.924 -3.221  1.00 55.15  ? 381 TYR A C   1 
ATOM   2627 O O   . TYR A 1 381 ? -38.381 -46.777 -3.537  1.00 52.57  ? 381 TYR A O   1 
ATOM   2628 C CB  . TYR A 1 381 ? -37.908 -43.854 -2.722  1.00 52.57  ? 381 TYR A CB  1 
ATOM   2629 C CG  . TYR A 1 381 ? -37.302 -42.904 -1.715  1.00 51.43  ? 381 TYR A CG  1 
ATOM   2630 C CD1 . TYR A 1 381 ? -38.111 -42.151 -0.876  1.00 52.66  ? 381 TYR A CD1 1 
ATOM   2631 C CD2 . TYR A 1 381 ? -35.925 -42.728 -1.636  1.00 47.84  ? 381 TYR A CD2 1 
ATOM   2632 C CE1 . TYR A 1 381 ? -37.568 -41.260 0.035   1.00 56.59  ? 381 TYR A CE1 1 
ATOM   2633 C CE2 . TYR A 1 381 ? -35.373 -41.846 -0.736  1.00 53.99  ? 381 TYR A CE2 1 
ATOM   2634 C CZ  . TYR A 1 381 ? -36.196 -41.104 0.107   1.00 59.87  ? 381 TYR A CZ  1 
ATOM   2635 O OH  . TYR A 1 381 ? -35.652 -40.205 1.023   1.00 56.09  ? 381 TYR A OH  1 
ATOM   2636 N N   . GLY A 1 382 ? -40.432 -45.854 -3.767  1.00 54.19  ? 382 GLY A N   1 
ATOM   2637 C CA  . GLY A 1 382 ? -40.799 -46.726 -4.864  1.00 54.09  ? 382 GLY A CA  1 
ATOM   2638 C C   . GLY A 1 382 ? -41.507 -47.987 -4.420  1.00 54.93  ? 382 GLY A C   1 
ATOM   2639 O O   . GLY A 1 382 ? -42.125 -48.020 -3.347  1.00 57.70  ? 382 GLY A O   1 
ATOM   2640 N N   . ASN A 1 383 ? -41.395 -49.030 -5.244  1.00 56.13  ? 383 ASN A N   1 
ATOM   2641 C CA  . ASN A 1 383 ? -42.067 -50.313 -5.071  1.00 52.80  ? 383 ASN A CA  1 
ATOM   2642 C C   . ASN A 1 383 ? -41.059 -51.368 -4.615  1.00 56.25  ? 383 ASN A C   1 
ATOM   2643 O O   . ASN A 1 383 ? -39.889 -51.345 -5.032  1.00 53.02  ? 383 ASN A O   1 
ATOM   2644 C CB  . ASN A 1 383 ? -42.712 -50.766 -6.392  1.00 51.89  ? 383 ASN A CB  1 
ATOM   2645 C CG  . ASN A 1 383 ? -44.055 -50.091 -6.673  1.00 51.53  ? 383 ASN A CG  1 
ATOM   2646 O OD1 . ASN A 1 383 ? -44.821 -49.787 -5.758  1.00 54.72  ? 383 ASN A OD1 1 
ATOM   2647 N ND2 . ASN A 1 383 ? -44.350 -49.873 -7.957  1.00 54.21  ? 383 ASN A ND2 1 
ATOM   2648 N N   . LYS A 1 384 ? -41.516 -52.303 -3.767  1.00 58.95  ? 384 LYS A N   1 
ATOM   2649 C CA  . LYS A 1 384 ? -40.650 -53.361 -3.241  1.00 56.10  ? 384 LYS A CA  1 
ATOM   2650 C C   . LYS A 1 384 ? -40.472 -54.484 -4.267  1.00 59.80  ? 384 LYS A C   1 
ATOM   2651 O O   . LYS A 1 384 ? -41.274 -54.674 -5.195  1.00 54.06  ? 384 LYS A O   1 
ATOM   2652 C CB  . LYS A 1 384 ? -41.192 -53.943 -1.940  1.00 48.60  ? 384 LYS A CB  1 
ATOM   2653 C CG  . LYS A 1 384 ? -41.472 -52.920 -0.827  1.00 58.30  ? 384 LYS A CG  1 
ATOM   2654 C CD  . LYS A 1 384 ? -40.391 -52.817 0.244   1.00 52.18  ? 384 LYS A CD  1 
ATOM   2655 C CE  . LYS A 1 384 ? -40.971 -52.027 1.430   1.00 51.63  ? 384 LYS A CE  1 
ATOM   2656 N NZ  . LYS A 1 384 ? -40.380 -52.427 2.751   1.00 52.45  ? 384 LYS A NZ  1 
ATOM   2657 N N   . SER A 1 385 ? -39.409 -55.255 -4.051  1.00 62.66  ? 385 SER A N   1 
ATOM   2658 C CA  . SER A 1 385 ? -38.758 -56.037 -5.094  1.00 60.99  ? 385 SER A CA  1 
ATOM   2659 C C   . SER A 1 385 ? -39.454 -57.388 -5.306  1.00 68.63  ? 385 SER A C   1 
ATOM   2660 O O   . SER A 1 385 ? -39.923 -58.020 -4.349  1.00 64.71  ? 385 SER A O   1 
ATOM   2661 C CB  . SER A 1 385 ? -37.285 -56.227 -4.702  1.00 56.29  ? 385 SER A CB  1 
ATOM   2662 O OG  . SER A 1 385 ? -36.466 -56.625 -5.788  1.00 59.32  ? 385 SER A OG  1 
ATOM   2663 N N   . SER A 1 386 ? -39.542 -57.822 -6.579  1.00 64.82  ? 386 SER A N   1 
ATOM   2664 C CA  . SER A 1 386 ? -40.061 -59.149 -6.915  1.00 62.12  ? 386 SER A CA  1 
ATOM   2665 C C   . SER A 1 386 ? -38.981 -60.118 -7.378  1.00 62.00  ? 386 SER A C   1 
ATOM   2666 O O   . SER A 1 386 ? -39.278 -61.299 -7.584  1.00 65.28  ? 386 SER A O   1 
ATOM   2667 C CB  . SER A 1 386 ? -41.164 -59.069 -7.994  1.00 61.35  ? 386 SER A CB  1 
ATOM   2668 O OG  . SER A 1 386 ? -40.670 -58.842 -9.306  1.00 62.32  ? 386 SER A OG  1 
ATOM   2669 N N   . GLU A 1 387 ? -37.757 -59.651 -7.572  1.00 59.82  ? 387 GLU A N   1 
ATOM   2670 C CA  . GLU A 1 387 ? -36.592 -60.488 -7.808  1.00 58.40  ? 387 GLU A CA  1 
ATOM   2671 C C   . GLU A 1 387 ? -35.744 -60.256 -6.566  1.00 64.78  ? 387 GLU A C   1 
ATOM   2672 O O   . GLU A 1 387 ? -36.197 -59.528 -5.674  1.00 68.25  ? 387 GLU A O   1 
ATOM   2673 C CB  . GLU A 1 387 ? -35.863 -60.117 -9.109  1.00 59.09  ? 387 GLU A CB  1 
ATOM   2674 C CG  . GLU A 1 387 ? -36.730 -60.120 -10.368 1.00 64.48  ? 387 GLU A CG  1 
ATOM   2675 C CD  . GLU A 1 387 ? -37.438 -61.456 -10.627 1.00 72.71  ? 387 GLU A CD  1 
ATOM   2676 O OE1 . GLU A 1 387 ? -36.760 -62.509 -10.690 1.00 68.98  ? 387 GLU A OE1 1 
ATOM   2677 O OE2 . GLU A 1 387 ? -38.684 -61.443 -10.793 1.00 73.19  ? 387 GLU A OE2 1 
ATOM   2678 N N   . PRO A 1 388 ? -34.558 -60.851 -6.427  1.00 65.19  ? 388 PRO A N   1 
ATOM   2679 C CA  . PRO A 1 388 ? -33.742 -60.550 -5.247  1.00 64.80  ? 388 PRO A CA  1 
ATOM   2680 C C   . PRO A 1 388 ? -33.106 -59.166 -5.311  1.00 67.37  ? 388 PRO A C   1 
ATOM   2681 O O   . PRO A 1 388 ? -32.771 -58.646 -6.381  1.00 68.84  ? 388 PRO A O   1 
ATOM   2682 C CB  . PRO A 1 388 ? -32.681 -61.654 -5.255  1.00 66.63  ? 388 PRO A CB  1 
ATOM   2683 C CG  . PRO A 1 388 ? -33.281 -62.752 -6.048  1.00 70.67  ? 388 PRO A CG  1 
ATOM   2684 C CD  . PRO A 1 388 ? -34.073 -62.065 -7.110  1.00 69.78  ? 388 PRO A CD  1 
ATOM   2685 N N   . VAL A 1 389 ? -32.928 -58.593 -4.117  1.00 61.26  ? 389 VAL A N   1 
ATOM   2686 C CA  . VAL A 1 389 ? -32.346 -57.275 -3.868  1.00 59.03  ? 389 VAL A CA  1 
ATOM   2687 C C   . VAL A 1 389 ? -30.838 -57.243 -4.148  1.00 55.56  ? 389 VAL A C   1 
ATOM   2688 O O   . VAL A 1 389 ? -30.113 -58.222 -3.916  1.00 57.21  ? 389 VAL A O   1 
ATOM   2689 C CB  . VAL A 1 389 ? -32.685 -56.896 -2.406  1.00 51.83  ? 389 VAL A CB  1 
ATOM   2690 C CG1 . VAL A 1 389 ? -31.705 -55.921 -1.825  1.00 56.30  ? 389 VAL A CG1 1 
ATOM   2691 C CG2 . VAL A 1 389 ? -34.069 -56.314 -2.352  1.00 52.25  ? 389 VAL A CG2 1 
ATOM   2692 N N   . GLN A 1 390 ? -30.354 -56.100 -4.655  1.00 48.74  ? 390 GLN A N   1 
ATOM   2693 C CA  . GLN A 1 390 ? -28.930 -55.840 -4.861  1.00 48.37  ? 390 GLN A CA  1 
ATOM   2694 C C   . GLN A 1 390 ? -28.446 -54.687 -3.985  1.00 57.25  ? 390 GLN A C   1 
ATOM   2695 O O   . GLN A 1 390 ? -29.057 -53.607 -3.984  1.00 55.58  ? 390 GLN A O   1 
ATOM   2696 C CB  . GLN A 1 390 ? -28.629 -55.497 -6.315  1.00 40.35  ? 390 GLN A CB  1 
ATOM   2697 C CG  . GLN A 1 390 ? -29.206 -56.411 -7.328  1.00 37.43  ? 390 GLN A CG  1 
ATOM   2698 C CD  . GLN A 1 390 ? -28.688 -56.088 -8.698  1.00 37.78  ? 390 GLN A CD  1 
ATOM   2699 O OE1 . GLN A 1 390 ? -27.546 -55.659 -8.846  1.00 42.48  ? 390 GLN A OE1 1 
ATOM   2700 N NE2 . GLN A 1 390 ? -29.498 -56.332 -9.713  1.00 39.68  ? 390 GLN A NE2 1 
ATOM   2701 N N   . ASN A 1 391 ? -27.315 -54.896 -3.286  1.00 62.03  ? 391 ASN A N   1 
ATOM   2702 C CA  . ASN A 1 391 ? -26.678 -53.874 -2.449  1.00 54.92  ? 391 ASN A CA  1 
ATOM   2703 C C   . ASN A 1 391 ? -25.309 -53.507 -2.998  1.00 51.60  ? 391 ASN A C   1 
ATOM   2704 O O   . ASN A 1 391 ? -24.466 -54.386 -3.192  1.00 53.35  ? 391 ASN A O   1 
ATOM   2705 C CB  . ASN A 1 391 ? -26.537 -54.335 -0.994  1.00 44.56  ? 391 ASN A CB  1 
ATOM   2706 C CG  . ASN A 1 391 ? -27.779 -54.071 -0.184  1.00 52.04  ? 391 ASN A CG  1 
ATOM   2707 O OD1 . ASN A 1 391 ? -28.887 -54.388 -0.607  1.00 47.82  ? 391 ASN A OD1 1 
ATOM   2708 N ND2 . ASN A 1 391 ? -27.609 -53.432 0.970   1.00 63.27  ? 391 ASN A ND2 1 
ATOM   2709 N N   . LEU A 1 392 ? -25.081 -52.213 -3.222  1.00 53.68  ? 392 LEU A N   1 
ATOM   2710 C CA  . LEU A 1 392 ? -23.743 -51.686 -3.453  1.00 52.32  ? 392 LEU A CA  1 
ATOM   2711 C C   . LEU A 1 392 ? -23.338 -50.803 -2.275  1.00 56.66  ? 392 LEU A C   1 
ATOM   2712 O O   . LEU A 1 392 ? -24.164 -50.055 -1.733  1.00 50.52  ? 392 LEU A O   1 
ATOM   2713 C CB  . LEU A 1 392 ? -23.664 -50.891 -4.752  1.00 49.71  ? 392 LEU A CB  1 
ATOM   2714 C CG  . LEU A 1 392 ? -23.974 -51.597 -6.080  1.00 50.24  ? 392 LEU A CG  1 
ATOM   2715 C CD1 . LEU A 1 392 ? -24.109 -50.560 -7.194  1.00 51.41  ? 392 LEU A CD1 1 
ATOM   2716 C CD2 . LEU A 1 392 ? -22.953 -52.663 -6.463  1.00 49.41  ? 392 LEU A CD2 1 
ATOM   2717 N N   . GLU A 1 393 ? -22.074 -50.934 -1.852  1.00 60.00  ? 393 GLU A N   1 
ATOM   2718 C CA  . GLU A 1 393 ? -21.504 -50.129 -0.774  1.00 55.73  ? 393 GLU A CA  1 
ATOM   2719 C C   . GLU A 1 393 ? -20.593 -49.075 -1.372  1.00 53.53  ? 393 GLU A C   1 
ATOM   2720 O O   . GLU A 1 393 ? -19.732 -49.391 -2.197  1.00 53.92  ? 393 GLU A O   1 
ATOM   2721 C CB  . GLU A 1 393 ? -20.707 -50.954 0.244   1.00 51.12  ? 393 GLU A CB  1 
ATOM   2722 C CG  . GLU A 1 393 ? -21.406 -52.160 0.792   1.00 57.51  ? 393 GLU A CG  1 
ATOM   2723 C CD  . GLU A 1 393 ? -22.112 -51.831 2.086   1.00 74.51  ? 393 GLU A CD  1 
ATOM   2724 O OE1 . GLU A 1 393 ? -22.281 -52.731 2.946   1.00 83.40  ? 393 GLU A OE1 1 
ATOM   2725 O OE2 . GLU A 1 393 ? -22.506 -50.651 2.239   1.00 75.65  ? 393 GLU A OE2 1 
ATOM   2726 N N   . PHE A 1 394 ? -20.772 -47.830 -0.936  1.00 56.21  ? 394 PHE A N   1 
ATOM   2727 C CA  . PHE A 1 394 ? -19.995 -46.726 -1.472  1.00 51.82  ? 394 PHE A CA  1 
ATOM   2728 C C   . PHE A 1 394 ? -19.151 -46.023 -0.417  1.00 59.66  ? 394 PHE A C   1 
ATOM   2729 O O   . PHE A 1 394 ? -18.739 -44.885 -0.650  1.00 66.41  ? 394 PHE A O   1 
ATOM   2730 C CB  . PHE A 1 394 ? -20.907 -45.715 -2.151  1.00 48.05  ? 394 PHE A CB  1 
ATOM   2731 C CG  . PHE A 1 394 ? -21.590 -46.238 -3.369  1.00 51.52  ? 394 PHE A CG  1 
ATOM   2732 C CD1 . PHE A 1 394 ? -20.886 -46.391 -4.562  1.00 49.33  ? 394 PHE A CD1 1 
ATOM   2733 C CD2 . PHE A 1 394 ? -22.953 -46.533 -3.337  1.00 47.71  ? 394 PHE A CD2 1 
ATOM   2734 C CE1 . PHE A 1 394 ? -21.523 -46.857 -5.698  1.00 51.79  ? 394 PHE A CE1 1 
ATOM   2735 C CE2 . PHE A 1 394 ? -23.606 -46.992 -4.472  1.00 46.64  ? 394 PHE A CE2 1 
ATOM   2736 C CZ  . PHE A 1 394 ? -22.896 -47.152 -5.657  1.00 51.60  ? 394 PHE A CZ  1 
ATOM   2737 N N   . ASN A 1 395 ? -18.866 -46.660 0.724   1.00 55.90  ? 395 ASN A N   1 
ATOM   2738 C CA  . ASN A 1 395 ? -17.953 -46.060 1.693   1.00 57.63  ? 395 ASN A CA  1 
ATOM   2739 C C   . ASN A 1 395 ? -16.589 -45.744 1.063   1.00 56.15  ? 395 ASN A C   1 
ATOM   2740 O O   . ASN A 1 395 ? -15.941 -46.620 0.484   1.00 54.82  ? 395 ASN A O   1 
ATOM   2741 C CB  . ASN A 1 395 ? -17.763 -46.990 2.888   1.00 62.28  ? 395 ASN A CB  1 
ATOM   2742 C CG  . ASN A 1 395 ? -17.065 -46.298 4.052   1.00 61.68  ? 395 ASN A CG  1 
ATOM   2743 O OD1 . ASN A 1 395 ? -17.224 -45.097 4.258   1.00 66.37  ? 395 ASN A OD1 1 
ATOM   2744 N ND2 . ASN A 1 395 ? -16.212 -47.031 4.752   1.00 58.46  ? 395 ASN A ND2 1 
ATOM   2745 N N   . GLY A 1 396 ? -16.149 -44.483 1.190   1.00 53.39  ? 396 GLY A N   1 
ATOM   2746 C CA  . GLY A 1 396 ? -14.842 -44.051 0.729   1.00 53.51  ? 396 GLY A CA  1 
ATOM   2747 C C   . GLY A 1 396 ? -14.732 -43.799 -0.759  1.00 60.52  ? 396 GLY A C   1 
ATOM   2748 O O   . GLY A 1 396 ? -13.663 -43.360 -1.231  1.00 60.79  ? 396 GLY A O   1 
ATOM   2749 N N   . GLU A 1 397 ? -15.801 -44.047 -1.511  1.00 58.26  ? 397 GLU A N   1 
ATOM   2750 C CA  . GLU A 1 397 ? -15.813 -43.889 -2.955  1.00 61.84  ? 397 GLU A CA  1 
ATOM   2751 C C   . GLU A 1 397 ? -16.569 -42.627 -3.365  1.00 54.66  ? 397 GLU A C   1 
ATOM   2752 O O   . GLU A 1 397 ? -17.487 -42.163 -2.681  1.00 50.80  ? 397 GLU A O   1 
ATOM   2753 C CB  . GLU A 1 397 ? -16.423 -45.122 -3.640  1.00 57.59  ? 397 GLU A CB  1 
ATOM   2754 C CG  . GLU A 1 397 ? -15.781 -46.471 -3.258  1.00 63.76  ? 397 GLU A CG  1 
ATOM   2755 C CD  . GLU A 1 397 ? -14.457 -46.735 -3.969  1.00 68.74  ? 397 GLU A CD  1 
ATOM   2756 O OE1 . GLU A 1 397 ? -14.378 -46.443 -5.187  1.00 66.30  ? 397 GLU A OE1 1 
ATOM   2757 O OE2 . GLU A 1 397 ? -13.510 -47.250 -3.319  1.00 68.27  ? 397 GLU A OE2 1 
ATOM   2758 N N   . LYS A 1 398 ? -16.169 -42.082 -4.504  1.00 49.75  ? 398 LYS A N   1 
ATOM   2759 C CA  . LYS A 1 398 ? -16.750 -40.870 -5.050  1.00 52.48  ? 398 LYS A CA  1 
ATOM   2760 C C   . LYS A 1 398 ? -17.262 -41.225 -6.434  1.00 51.80  ? 398 LYS A C   1 
ATOM   2761 O O   . LYS A 1 398 ? -16.465 -41.520 -7.331  1.00 49.76  ? 398 LYS A O   1 
ATOM   2762 C CB  . LYS A 1 398 ? -15.706 -39.755 -5.074  1.00 60.25  ? 398 LYS A CB  1 
ATOM   2763 C CG  . LYS A 1 398 ? -15.401 -39.243 -3.668  1.00 55.92  ? 398 LYS A CG  1 
ATOM   2764 C CD  . LYS A 1 398 ? -14.142 -38.429 -3.580  1.00 47.58  ? 398 LYS A CD  1 
ATOM   2765 C CE  . LYS A 1 398 ? -13.841 -38.202 -2.118  1.00 58.73  ? 398 LYS A CE  1 
ATOM   2766 N NZ  . LYS A 1 398 ? -12.459 -37.725 -1.921  1.00 67.76  ? 398 LYS A NZ  1 
ATOM   2767 N N   . VAL A 1 399 ? -18.592 -41.223 -6.594  1.00 49.48  ? 399 VAL A N   1 
ATOM   2768 C CA  . VAL A 1 399 ? -19.233 -41.740 -7.803  1.00 46.76  ? 399 VAL A CA  1 
ATOM   2769 C C   . VAL A 1 399 ? -19.234 -40.685 -8.890  1.00 41.40  ? 399 VAL A C   1 
ATOM   2770 O O   . VAL A 1 399 ? -20.205 -39.942 -9.034  1.00 47.49  ? 399 VAL A O   1 
ATOM   2771 C CB  . VAL A 1 399 ? -20.671 -42.196 -7.520  1.00 44.48  ? 399 VAL A CB  1 
ATOM   2772 C CG1 . VAL A 1 399 ? -21.313 -42.708 -8.797  1.00 46.46  ? 399 VAL A CG1 1 
ATOM   2773 C CG2 . VAL A 1 399 ? -20.692 -43.266 -6.448  1.00 45.05  ? 399 VAL A CG2 1 
ATOM   2774 N N   . TYR A 1 400 ? -18.170 -40.614 -9.671  1.00 43.48  ? 400 TYR A N   1 
ATOM   2775 C CA  . TYR A 1 400 ? -18.011 -39.488 -10.581 1.00 47.30  ? 400 TYR A CA  1 
ATOM   2776 C C   . TYR A 1 400 ? -18.804 -39.621 -11.869 1.00 48.84  ? 400 TYR A C   1 
ATOM   2777 O O   . TYR A 1 400 ? -18.738 -38.708 -12.702 1.00 46.54  ? 400 TYR A O   1 
ATOM   2778 C CB  . TYR A 1 400 ? -16.537 -39.287 -10.899 1.00 53.56  ? 400 TYR A CB  1 
ATOM   2779 C CG  . TYR A 1 400 ? -15.883 -40.427 -11.615 1.00 53.44  ? 400 TYR A CG  1 
ATOM   2780 C CD1 . TYR A 1 400 ? -15.887 -40.503 -13.001 1.00 51.96  ? 400 TYR A CD1 1 
ATOM   2781 C CD2 . TYR A 1 400 ? -15.268 -41.441 -10.901 1.00 58.92  ? 400 TYR A CD2 1 
ATOM   2782 C CE1 . TYR A 1 400 ? -15.281 -41.554 -13.664 1.00 57.36  ? 400 TYR A CE1 1 
ATOM   2783 C CE2 . TYR A 1 400 ? -14.672 -42.507 -11.550 1.00 67.18  ? 400 TYR A CE2 1 
ATOM   2784 C CZ  . TYR A 1 400 ? -14.682 -42.568 -12.931 1.00 66.53  ? 400 TYR A CZ  1 
ATOM   2785 O OH  . TYR A 1 400 ? -14.079 -43.644 -13.559 1.00 59.37  ? 400 TYR A OH  1 
ATOM   2786 N N   . ARG A 1 401 ? -19.562 -40.706 -12.039 1.00 53.11  ? 401 ARG A N   1 
ATOM   2787 C CA  . ARG A 1 401 ? -20.348 -40.921 -13.249 1.00 51.79  ? 401 ARG A CA  1 
ATOM   2788 C C   . ARG A 1 401 ? -21.480 -41.914 -13.000 1.00 53.70  ? 401 ARG A C   1 
ATOM   2789 O O   . ARG A 1 401 ? -21.401 -42.762 -12.101 1.00 53.81  ? 401 ARG A O   1 
ATOM   2790 C CB  . ARG A 1 401 ? -19.463 -41.416 -14.389 1.00 46.53  ? 401 ARG A CB  1 
ATOM   2791 C CG  . ARG A 1 401 ? -19.895 -40.930 -15.715 1.00 46.75  ? 401 ARG A CG  1 
ATOM   2792 C CD  . ARG A 1 401 ? -19.416 -41.853 -16.782 1.00 45.16  ? 401 ARG A CD  1 
ATOM   2793 N NE  . ARG A 1 401 ? -19.907 -41.392 -18.066 1.00 54.70  ? 401 ARG A NE  1 
ATOM   2794 C CZ  . ARG A 1 401 ? -19.415 -41.783 -19.233 1.00 59.38  ? 401 ARG A CZ  1 
ATOM   2795 N NH1 . ARG A 1 401 ? -18.371 -42.595 -19.251 1.00 60.75  ? 401 ARG A NH1 1 
ATOM   2796 N NH2 . ARG A 1 401 ? -19.925 -41.321 -20.373 1.00 56.43  ? 401 ARG A NH2 1 
ATOM   2797 N N   . ALA A 1 402 ? -22.537 -41.789 -13.814 1.00 53.67  ? 402 ALA A N   1 
ATOM   2798 C CA  . ALA A 1 402 ? -23.621 -42.767 -13.875 1.00 54.89  ? 402 ALA A CA  1 
ATOM   2799 C C   . ALA A 1 402 ? -24.192 -42.848 -15.293 1.00 58.39  ? 402 ALA A C   1 
ATOM   2800 O O   . ALA A 1 402 ? -24.585 -41.826 -15.876 1.00 50.85  ? 402 ALA A O   1 
ATOM   2801 C CB  . ALA A 1 402 ? -24.726 -42.426 -12.871 1.00 47.10  ? 402 ALA A CB  1 
ATOM   2802 N N   . VAL A 1 403 ? -24.237 -44.080 -15.827 1.00 60.99  ? 403 VAL A N   1 
ATOM   2803 C CA  . VAL A 1 403 ? -24.755 -44.409 -17.155 1.00 51.47  ? 403 VAL A CA  1 
ATOM   2804 C C   . VAL A 1 403 ? -25.824 -45.481 -17.013 1.00 45.31  ? 403 VAL A C   1 
ATOM   2805 O O   . VAL A 1 403 ? -25.627 -46.445 -16.272 1.00 52.60  ? 403 VAL A O   1 
ATOM   2806 C CB  . VAL A 1 403 ? -23.626 -44.910 -18.069 1.00 53.15  ? 403 VAL A CB  1 
ATOM   2807 C CG1 . VAL A 1 403 ? -24.145 -45.138 -19.474 1.00 56.26  ? 403 VAL A CG1 1 
ATOM   2808 C CG2 . VAL A 1 403 ? -22.472 -43.913 -18.058 1.00 59.38  ? 403 VAL A CG2 1 
ATOM   2809 N N   . ALA A 1 404 ? -26.937 -45.342 -17.740 1.00 44.54  ? 404 ALA A N   1 
ATOM   2810 C CA  . ALA A 1 404 ? -28.092 -46.206 -17.496 1.00 52.00  ? 404 ALA A CA  1 
ATOM   2811 C C   . ALA A 1 404 ? -28.768 -46.713 -18.776 1.00 51.00  ? 404 ALA A C   1 
ATOM   2812 O O   . ALA A 1 404 ? -28.892 -45.993 -19.772 1.00 49.72  ? 404 ALA A O   1 
ATOM   2813 C CB  . ALA A 1 404 ? -29.135 -45.475 -16.650 1.00 53.59  ? 404 ALA A CB  1 
ATOM   2814 N N   . ASN A 1 405 ? -29.266 -47.949 -18.709 1.00 50.86  ? 405 ASN A N   1 
ATOM   2815 C CA  . ASN A 1 405 ? -30.130 -48.532 -19.735 1.00 56.05  ? 405 ASN A CA  1 
ATOM   2816 C C   . ASN A 1 405 ? -31.612 -48.468 -19.353 1.00 58.25  ? 405 ASN A C   1 
ATOM   2817 O O   . ASN A 1 405 ? -31.992 -48.670 -18.190 1.00 57.42  ? 405 ASN A O   1 
ATOM   2818 C CB  . ASN A 1 405 ? -29.783 -50.001 -19.996 1.00 55.44  ? 405 ASN A CB  1 
ATOM   2819 C CG  . ASN A 1 405 ? -28.310 -50.231 -20.189 1.00 61.36  ? 405 ASN A CG  1 
ATOM   2820 O OD1 . ASN A 1 405 ? -27.482 -49.779 -19.388 1.00 65.09  ? 405 ASN A OD1 1 
ATOM   2821 N ND2 . ASN A 1 405 ? -27.964 -50.943 -21.262 1.00 57.04  ? 405 ASN A ND2 1 
ATOM   2822 N N   . THR A 1 406 ? -32.455 -48.257 -20.355 1.00 55.24  ? 406 THR A N   1 
ATOM   2823 C CA  . THR A 1 406 ? -33.894 -48.296 -20.165 1.00 55.81  ? 406 THR A CA  1 
ATOM   2824 C C   . THR A 1 406 ? -34.510 -49.245 -21.185 1.00 53.73  ? 406 THR A C   1 
ATOM   2825 O O   . THR A 1 406 ? -33.839 -49.717 -22.110 1.00 54.09  ? 406 THR A O   1 
ATOM   2826 C CB  . THR A 1 406 ? -34.499 -46.902 -20.293 1.00 57.53  ? 406 THR A CB  1 
ATOM   2827 O OG1 . THR A 1 406 ? -34.289 -46.397 -21.619 1.00 53.39  ? 406 THR A OG1 1 
ATOM   2828 C CG2 . THR A 1 406 ? -33.808 -45.990 -19.305 1.00 56.40  ? 406 THR A CG2 1 
ATOM   2829 N N   . ASN A 1 407 ? -35.803 -49.514 -21.019 1.00 47.28  ? 407 ASN A N   1 
ATOM   2830 C CA  . ASN A 1 407 ? -36.467 -50.462 -21.904 1.00 49.01  ? 407 ASN A CA  1 
ATOM   2831 C C   . ASN A 1 407 ? -37.977 -50.370 -21.713 1.00 46.80  ? 407 ASN A C   1 
ATOM   2832 O O   . ASN A 1 407 ? -38.458 -50.021 -20.637 1.00 53.94  ? 407 ASN A O   1 
ATOM   2833 C CB  . ASN A 1 407 ? -35.969 -51.888 -21.637 1.00 58.82  ? 407 ASN A CB  1 
ATOM   2834 C CG  . ASN A 1 407 ? -36.112 -52.798 -22.839 1.00 54.03  ? 407 ASN A CG  1 
ATOM   2835 O OD1 . ASN A 1 407 ? -36.561 -52.377 -23.907 1.00 48.61  ? 407 ASN A OD1 1 
ATOM   2836 N ND2 . ASN A 1 407 ? -35.713 -54.053 -22.674 1.00 56.95  ? 407 ASN A ND2 1 
ATOM   2837 N N   . LEU A 1 408 ? -38.716 -50.693 -22.766 1.00 48.00  ? 408 LEU A N   1 
ATOM   2838 C CA  . LEU A 1 408 ? -40.157 -50.512 -22.759 1.00 51.35  ? 408 LEU A CA  1 
ATOM   2839 C C   . LEU A 1 408 ? -40.836 -51.704 -23.428 1.00 47.82  ? 408 LEU A C   1 
ATOM   2840 O O   . LEU A 1 408 ? -40.234 -52.428 -24.226 1.00 48.24  ? 408 LEU A O   1 
ATOM   2841 C CB  . LEU A 1 408 ? -40.545 -49.189 -23.453 1.00 46.53  ? 408 LEU A CB  1 
ATOM   2842 C CG  . LEU A 1 408 ? -40.083 -48.883 -24.887 1.00 37.73  ? 408 LEU A CG  1 
ATOM   2843 C CD1 . LEU A 1 408 ? -40.872 -49.656 -25.926 1.00 45.39  ? 408 LEU A CD1 1 
ATOM   2844 C CD2 . LEU A 1 408 ? -40.194 -47.436 -25.203 1.00 40.13  ? 408 LEU A CD2 1 
ATOM   2845 N N   . ALA A 1 409 ? -42.113 -51.892 -23.094 1.00 50.88  ? 409 ALA A N   1 
ATOM   2846 C CA  . ALA A 1 409 ? -42.969 -52.895 -23.717 1.00 61.86  ? 409 ALA A CA  1 
ATOM   2847 C C   . ALA A 1 409 ? -44.241 -52.214 -24.198 1.00 58.15  ? 409 ALA A C   1 
ATOM   2848 O O   . ALA A 1 409 ? -44.937 -51.579 -23.404 1.00 57.02  ? 409 ALA A O   1 
ATOM   2849 C CB  . ALA A 1 409 ? -43.311 -54.017 -22.737 1.00 66.68  ? 409 ALA A CB  1 
ATOM   2850 N N   . VAL A 1 410 ? -44.537 -52.330 -25.488 1.00 55.58  ? 410 VAL A N   1 
ATOM   2851 C CA  . VAL A 1 410 ? -45.724 -51.707 -26.063 1.00 59.60  ? 410 VAL A CA  1 
ATOM   2852 C C   . VAL A 1 410 ? -46.891 -52.670 -25.948 1.00 74.06  ? 410 VAL A C   1 
ATOM   2853 O O   . VAL A 1 410 ? -46.837 -53.798 -26.450 1.00 95.29  ? 410 VAL A O   1 
ATOM   2854 C CB  . VAL A 1 410 ? -45.494 -51.291 -27.522 1.00 62.84  ? 410 VAL A CB  1 
ATOM   2855 C CG1 . VAL A 1 410 ? -46.676 -50.481 -28.035 1.00 59.39  ? 410 VAL A CG1 1 
ATOM   2856 C CG2 . VAL A 1 410 ? -44.236 -50.464 -27.635 1.00 49.28  ? 410 VAL A CG2 1 
ATOM   2857 N N   . TRP A 1 411 ? -47.943 -52.221 -25.292 1.00 68.66  ? 411 TRP A N   1 
ATOM   2858 C CA  . TRP A 1 411 ? -49.146 -52.956 -25.007 1.00 76.71  ? 411 TRP A CA  1 
ATOM   2859 C C   . TRP A 1 411 ? -50.289 -52.270 -25.717 1.00 80.70  ? 411 TRP A C   1 
ATOM   2860 O O   . TRP A 1 411 ? -50.236 -51.058 -25.948 1.00 79.29  ? 411 TRP A O   1 
ATOM   2861 C CB  . TRP A 1 411 ? -49.413 -52.961 -23.506 1.00 74.70  ? 411 TRP A CB  1 
ATOM   2862 C CG  . TRP A 1 411 ? -48.708 -54.007 -22.756 1.00 82.39  ? 411 TRP A CG  1 
ATOM   2863 C CD1 . TRP A 1 411 ? -47.780 -53.798 -21.795 1.00 87.29  ? 411 TRP A CD1 1 
ATOM   2864 C CD2 . TRP A 1 411 ? -48.972 -55.412 -22.756 1.00 91.74  ? 411 TRP A CD2 1 
ATOM   2865 N NE1 . TRP A 1 411 ? -47.378 -54.984 -21.258 1.00 93.62  ? 411 TRP A NE1 1 
ATOM   2866 C CE2 . TRP A 1 411 ? -48.105 -55.993 -21.825 1.00 95.61  ? 411 TRP A CE2 1 
ATOM   2867 C CE3 . TRP A 1 411 ? -49.830 -56.238 -23.477 1.00 98.42  ? 411 TRP A CE3 1 
ATOM   2868 C CZ2 . TRP A 1 411 ? -48.067 -57.363 -21.591 1.00 99.66  ? 411 TRP A CZ2 1 
ATOM   2869 C CZ3 . TRP A 1 411 ? -49.787 -57.604 -23.242 1.00 104.63 ? 411 TRP A CZ3 1 
ATOM   2870 C CH2 . TRP A 1 411 ? -48.912 -58.150 -22.306 1.00 97.94  ? 411 TRP A CH2 1 
ATOM   2871 N N   . PRO A 1 412 ? -51.314 -52.994 -26.084 1.00 86.44  ? 412 PRO A N   1 
ATOM   2872 C CA  . PRO A 1 412 ? -52.413 -52.352 -26.802 1.00 84.17  ? 412 PRO A CA  1 
ATOM   2873 C C   . PRO A 1 412 ? -52.993 -51.215 -25.973 1.00 75.33  ? 412 PRO A C   1 
ATOM   2874 O O   . PRO A 1 412 ? -53.396 -50.185 -26.521 1.00 73.93  ? 412 PRO A O   1 
ATOM   2875 C CB  . PRO A 1 412 ? -53.389 -53.511 -27.027 1.00 90.62  ? 412 PRO A CB  1 
ATOM   2876 C CG  . PRO A 1 412 ? -52.446 -54.706 -27.170 1.00 102.33 ? 412 PRO A CG  1 
ATOM   2877 C CD  . PRO A 1 412 ? -51.460 -54.459 -26.055 1.00 101.52 ? 412 PRO A CD  1 
ATOM   2878 N N   . SER A 1 413 ? -52.955 -51.347 -24.643 1.00 65.05  ? 413 SER A N   1 
ATOM   2879 C CA  . SER A 1 413 ? -53.557 -50.336 -23.784 1.00 71.66  ? 413 SER A CA  1 
ATOM   2880 C C   . SER A 1 413 ? -52.587 -49.286 -23.227 1.00 71.40  ? 413 SER A C   1 
ATOM   2881 O O   . SER A 1 413 ? -53.036 -48.181 -22.899 1.00 59.75  ? 413 SER A O   1 
ATOM   2882 C CB  . SER A 1 413 ? -54.302 -51.013 -22.614 1.00 62.56  ? 413 SER A CB  1 
ATOM   2883 O OG  . SER A 1 413 ? -53.466 -51.890 -21.877 1.00 55.27  ? 413 SER A OG  1 
ATOM   2884 N N   . ALA A 1 414 ? -51.286 -49.578 -23.139 1.00 66.94  ? 414 ALA A N   1 
ATOM   2885 C CA  . ALA A 1 414 ? -50.369 -48.787 -22.323 1.00 59.63  ? 414 ALA A CA  1 
ATOM   2886 C C   . ALA A 1 414 ? -48.935 -49.110 -22.716 1.00 64.58  ? 414 ALA A C   1 
ATOM   2887 O O   . ALA A 1 414 ? -48.678 -50.089 -23.416 1.00 66.97  ? 414 ALA A O   1 
ATOM   2888 C CB  . ALA A 1 414 ? -50.573 -49.074 -20.839 1.00 62.52  ? 414 ALA A CB  1 
ATOM   2889 N N   . VAL A 1 415 ? -47.997 -48.283 -22.237 1.00 61.69  ? 415 VAL A N   1 
ATOM   2890 C CA  . VAL A 1 415 ? -46.562 -48.520 -22.387 1.00 56.33  ? 415 VAL A CA  1 
ATOM   2891 C C   . VAL A 1 415 ? -45.968 -48.675 -20.990 1.00 53.84  ? 415 VAL A C   1 
ATOM   2892 O O   . VAL A 1 415 ? -46.477 -48.110 -20.021 1.00 60.23  ? 415 VAL A O   1 
ATOM   2893 C CB  . VAL A 1 415 ? -45.877 -47.381 -23.198 1.00 54.18  ? 415 VAL A CB  1 
ATOM   2894 C CG1 . VAL A 1 415 ? -44.350 -47.436 -23.138 1.00 46.69  ? 415 VAL A CG1 1 
ATOM   2895 C CG2 . VAL A 1 415 ? -46.304 -47.447 -24.653 1.00 51.98  ? 415 VAL A CG2 1 
ATOM   2896 N N   . TYR A 1 416 ? -44.923 -49.487 -20.864 1.00 55.72  ? 416 TYR A N   1 
ATOM   2897 C CA  . TYR A 1 416 ? -44.285 -49.673 -19.561 1.00 60.70  ? 416 TYR A CA  1 
ATOM   2898 C C   . TYR A 1 416 ? -42.770 -49.512 -19.690 1.00 59.22  ? 416 TYR A C   1 
ATOM   2899 O O   . TYR A 1 416 ? -42.073 -50.412 -20.171 1.00 56.50  ? 416 TYR A O   1 
ATOM   2900 C CB  . TYR A 1 416 ? -44.666 -51.017 -18.940 1.00 61.59  ? 416 TYR A CB  1 
ATOM   2901 C CG  . TYR A 1 416 ? -46.144 -51.137 -18.594 1.00 63.78  ? 416 TYR A CG  1 
ATOM   2902 C CD1 . TYR A 1 416 ? -47.078 -51.588 -19.534 1.00 62.24  ? 416 TYR A CD1 1 
ATOM   2903 C CD2 . TYR A 1 416 ? -46.611 -50.772 -17.342 1.00 65.65  ? 416 TYR A CD2 1 
ATOM   2904 C CE1 . TYR A 1 416 ? -48.434 -51.699 -19.228 1.00 54.22  ? 416 TYR A CE1 1 
ATOM   2905 C CE2 . TYR A 1 416 ? -47.971 -50.875 -17.026 1.00 76.35  ? 416 TYR A CE2 1 
ATOM   2906 C CZ  . TYR A 1 416 ? -48.876 -51.335 -17.976 1.00 64.41  ? 416 TYR A CZ  1 
ATOM   2907 O OH  . TYR A 1 416 ? -50.216 -51.426 -17.646 1.00 56.88  ? 416 TYR A OH  1 
ATOM   2908 N N   . SER A 1 417 ? -42.270 -48.365 -19.231 1.00 58.60  ? 417 SER A N   1 
ATOM   2909 C CA  . SER A 1 417 ? -40.851 -48.050 -19.256 1.00 54.43  ? 417 SER A CA  1 
ATOM   2910 C C   . SER A 1 417 ? -40.224 -48.273 -17.884 1.00 49.04  ? 417 SER A C   1 
ATOM   2911 O O   . SER A 1 417 ? -40.896 -48.195 -16.852 1.00 52.67  ? 417 SER A O   1 
ATOM   2912 C CB  . SER A 1 417 ? -40.634 -46.606 -19.711 1.00 55.83  ? 417 SER A CB  1 
ATOM   2913 O OG  . SER A 1 417 ? -40.590 -45.726 -18.610 1.00 58.99  ? 417 SER A OG  1 
ATOM   2914 N N   . GLY A 1 418 ? -38.924 -48.561 -17.890 1.00 43.65  ? 418 GLY A N   1 
ATOM   2915 C CA  . GLY A 1 418 ? -38.164 -48.742 -16.666 1.00 52.86  ? 418 GLY A CA  1 
ATOM   2916 C C   . GLY A 1 418 ? -36.676 -48.537 -16.873 1.00 51.93  ? 418 GLY A C   1 
ATOM   2917 O O   . GLY A 1 418 ? -36.174 -48.476 -17.997 1.00 50.35  ? 418 GLY A O   1 
ATOM   2918 N N   . VAL A 1 419 ? -35.965 -48.434 -15.756 1.00 50.81  ? 419 VAL A N   1 
ATOM   2919 C CA  . VAL A 1 419 ? -34.507 -48.384 -15.758 1.00 55.97  ? 419 VAL A CA  1 
ATOM   2920 C C   . VAL A 1 419 ? -33.995 -49.779 -15.487 1.00 53.62  ? 419 VAL A C   1 
ATOM   2921 O O   . VAL A 1 419 ? -34.262 -50.339 -14.420 1.00 52.89  ? 419 VAL A O   1 
ATOM   2922 C CB  . VAL A 1 419 ? -33.963 -47.416 -14.700 1.00 58.22  ? 419 VAL A CB  1 
ATOM   2923 C CG1 . VAL A 1 419 ? -32.435 -47.521 -14.649 1.00 54.47  ? 419 VAL A CG1 1 
ATOM   2924 C CG2 . VAL A 1 419 ? -34.407 -46.006 -14.999 1.00 54.84  ? 419 VAL A CG2 1 
ATOM   2925 N N   . THR A 1 420 ? -33.234 -50.333 -16.422 1.00 52.01  ? 420 THR A N   1 
ATOM   2926 C CA  . THR A 1 420 ? -32.837 -51.719 -16.249 1.00 56.53  ? 420 THR A CA  1 
ATOM   2927 C C   . THR A 1 420 ? -31.422 -51.854 -15.729 1.00 53.14  ? 420 THR A C   1 
ATOM   2928 O O   . THR A 1 420 ? -31.101 -52.846 -15.076 1.00 52.26  ? 420 THR A O   1 
ATOM   2929 C CB  . THR A 1 420 ? -32.972 -52.486 -17.569 1.00 53.78  ? 420 THR A CB  1 
ATOM   2930 O OG1 . THR A 1 420 ? -31.950 -52.045 -18.459 1.00 55.90  ? 420 THR A OG1 1 
ATOM   2931 C CG2 . THR A 1 420 ? -34.350 -52.228 -18.220 1.00 49.59  ? 420 THR A CG2 1 
ATOM   2932 N N   . LYS A 1 421 ? -30.574 -50.872 -15.973 1.00 51.80  ? 421 LYS A N   1 
ATOM   2933 C CA  . LYS A 1 421 ? -29.177 -51.028 -15.626 1.00 53.55  ? 421 LYS A CA  1 
ATOM   2934 C C   . LYS A 1 421 ? -28.679 -49.652 -15.231 1.00 55.22  ? 421 LYS A C   1 
ATOM   2935 O O   . LYS A 1 421 ? -29.074 -48.651 -15.838 1.00 50.83  ? 421 LYS A O   1 
ATOM   2936 C CB  . LYS A 1 421 ? -28.391 -51.613 -16.816 1.00 51.09  ? 421 LYS A CB  1 
ATOM   2937 C CG  . LYS A 1 421 ? -26.931 -51.964 -16.586 1.00 49.24  ? 421 LYS A CG  1 
ATOM   2938 C CD  . LYS A 1 421 ? -26.311 -52.475 -17.898 1.00 46.34  ? 421 LYS A CD  1 
ATOM   2939 C CE  . LYS A 1 421 ? -24.911 -53.123 -17.747 1.00 45.16  ? 421 LYS A CE  1 
ATOM   2940 N NZ  . LYS A 1 421 ? -24.823 -54.365 -16.912 1.00 41.89  ? 421 LYS A NZ  1 
ATOM   2941 N N   . VAL A 1 422 ? -27.869 -49.590 -14.176 1.00 50.97  ? 422 VAL A N   1 
ATOM   2942 C CA  . VAL A 1 422 ? -27.117 -48.374 -13.887 1.00 50.48  ? 422 VAL A CA  1 
ATOM   2943 C C   . VAL A 1 422 ? -25.725 -48.813 -13.474 1.00 50.43  ? 422 VAL A C   1 
ATOM   2944 O O   . VAL A 1 422 ? -25.551 -49.457 -12.434 1.00 54.54  ? 422 VAL A O   1 
ATOM   2945 C CB  . VAL A 1 422 ? -27.737 -47.470 -12.802 1.00 49.98  ? 422 VAL A CB  1 
ATOM   2946 C CG1 . VAL A 1 422 ? -26.910 -46.194 -12.707 1.00 43.21  ? 422 VAL A CG1 1 
ATOM   2947 C CG2 . VAL A 1 422 ? -29.189 -47.101 -13.098 1.00 45.49  ? 422 VAL A CG2 1 
ATOM   2948 N N   . GLU A 1 423 ? -24.746 -48.467 -14.282 1.00 50.97  ? 423 GLU A N   1 
ATOM   2949 C CA  . GLU A 1 423 ? -23.340 -48.620 -13.974 1.00 48.22  ? 423 GLU A CA  1 
ATOM   2950 C C   . GLU A 1 423 ? -22.801 -47.330 -13.358 1.00 55.83  ? 423 GLU A C   1 
ATOM   2951 O O   . GLU A 1 423 ? -22.933 -46.249 -13.950 1.00 52.81  ? 423 GLU A O   1 
ATOM   2952 C CB  . GLU A 1 423 ? -22.605 -48.941 -15.265 1.00 51.78  ? 423 GLU A CB  1 
ATOM   2953 C CG  . GLU A 1 423 ? -21.144 -48.722 -15.203 1.00 55.28  ? 423 GLU A CG  1 
ATOM   2954 C CD  . GLU A 1 423 ? -20.478 -49.287 -16.404 1.00 59.97  ? 423 GLU A CD  1 
ATOM   2955 O OE1 . GLU A 1 423 ? -20.552 -50.519 -16.606 1.00 72.92  ? 423 GLU A OE1 1 
ATOM   2956 O OE2 . GLU A 1 423 ? -19.951 -48.460 -17.180 1.00 53.12  ? 423 GLU A OE2 1 
ATOM   2957 N N   . PHE A 1 424 ? -22.172 -47.457 -12.175 1.00 56.18  ? 424 PHE A N   1 
ATOM   2958 C CA  . PHE A 1 424 ? -21.640 -46.343 -11.380 1.00 49.74  ? 424 PHE A CA  1 
ATOM   2959 C C   . PHE A 1 424 ? -20.111 -46.297 -11.466 1.00 47.93  ? 424 PHE A C   1 
ATOM   2960 O O   . PHE A 1 424 ? -19.433 -47.032 -10.747 1.00 48.01  ? 424 PHE A O   1 
ATOM   2961 C CB  . PHE A 1 424 ? -22.058 -46.511 -9.923  1.00 43.95  ? 424 PHE A CB  1 
ATOM   2962 C CG  . PHE A 1 424 ? -23.529 -46.582 -9.713  1.00 49.40  ? 424 PHE A CG  1 
ATOM   2963 C CD1 . PHE A 1 424 ? -24.298 -45.426 -9.651  1.00 53.67  ? 424 PHE A CD1 1 
ATOM   2964 C CD2 . PHE A 1 424 ? -24.163 -47.813 -9.621  1.00 52.44  ? 424 PHE A CD2 1 
ATOM   2965 C CE1 . PHE A 1 424 ? -25.681 -45.495 -9.450  1.00 46.02  ? 424 PHE A CE1 1 
ATOM   2966 C CE2 . PHE A 1 424 ? -25.542 -47.899 -9.437  1.00 51.45  ? 424 PHE A CE2 1 
ATOM   2967 C CZ  . PHE A 1 424 ? -26.302 -46.737 -9.349  1.00 46.22  ? 424 PHE A CZ  1 
ATOM   2968 N N   . SER A 1 425 ? -19.560 -45.415 -12.305 1.00 49.47  ? 425 SER A N   1 
ATOM   2969 C CA  . SER A 1 425 ? -18.119 -45.144 -12.259 1.00 55.57  ? 425 SER A CA  1 
ATOM   2970 C C   . SER A 1 425 ? -17.751 -44.450 -10.944 1.00 57.33  ? 425 SER A C   1 
ATOM   2971 O O   . SER A 1 425 ? -18.515 -43.617 -10.439 1.00 60.66  ? 425 SER A O   1 
ATOM   2972 C CB  . SER A 1 425 ? -17.696 -44.257 -13.430 1.00 55.03  ? 425 SER A CB  1 
ATOM   2973 O OG  . SER A 1 425 ? -18.108 -44.778 -14.683 1.00 54.28  ? 425 SER A OG  1 
ATOM   2974 N N   . GLN A 1 426 ? -16.576 -44.771 -10.388 1.00 54.48  ? 426 GLN A N   1 
ATOM   2975 C CA  . GLN A 1 426 ? -16.252 -44.302 -9.039  1.00 56.35  ? 426 GLN A CA  1 
ATOM   2976 C C   . GLN A 1 426 ? -14.730 -44.206 -8.854  1.00 61.26  ? 426 GLN A C   1 
ATOM   2977 O O   . GLN A 1 426 ? -13.963 -44.758 -9.641  1.00 64.79  ? 426 GLN A O   1 
ATOM   2978 C CB  . GLN A 1 426 ? -16.941 -45.206 -7.995  1.00 48.89  ? 426 GLN A CB  1 
ATOM   2979 C CG  . GLN A 1 426 ? -16.373 -46.607 -7.833  1.00 53.67  ? 426 GLN A CG  1 
ATOM   2980 C CD  . GLN A 1 426 ? -17.116 -47.444 -6.762  1.00 60.40  ? 426 GLN A CD  1 
ATOM   2981 O OE1 . GLN A 1 426 ? -18.160 -47.032 -6.242  1.00 62.15  ? 426 GLN A OE1 1 
ATOM   2982 N NE2 . GLN A 1 426 ? -16.571 -48.620 -6.435  1.00 53.17  ? 426 GLN A NE2 1 
ATOM   2983 N N   . TYR A 1 427 ? -14.291 -43.448 -7.835  1.00 67.22  ? 427 TYR A N   1 
ATOM   2984 C CA  . TYR A 1 427 ? -12.867 -43.222 -7.547  1.00 65.76  ? 427 TYR A CA  1 
ATOM   2985 C C   . TYR A 1 427 ? -12.628 -43.281 -6.041  1.00 62.52  ? 427 TYR A C   1 
ATOM   2986 O O   . TYR A 1 427 ? -13.565 -43.250 -5.246  1.00 66.75  ? 427 TYR A O   1 
ATOM   2987 C CB  . TYR A 1 427 ? -12.373 -41.864 -8.089  1.00 73.24  ? 427 TYR A CB  1 
ATOM   2988 C CG  . TYR A 1 427 ? -10.884 -41.554 -7.896  1.00 76.20  ? 427 TYR A CG  1 
ATOM   2989 C CD1 . TYR A 1 427 ? -9.911  -42.303 -8.536  1.00 73.98  ? 427 TYR A CD1 1 
ATOM   2990 C CD2 . TYR A 1 427 ? -10.462 -40.505 -7.074  1.00 82.69  ? 427 TYR A CD2 1 
ATOM   2991 C CE1 . TYR A 1 427 ? -8.565  -42.025 -8.370  1.00 77.70  ? 427 TYR A CE1 1 
ATOM   2992 C CE2 . TYR A 1 427 ? -9.112  -40.220 -6.901  1.00 79.27  ? 427 TYR A CE2 1 
ATOM   2993 C CZ  . TYR A 1 427 ? -8.169  -40.988 -7.555  1.00 81.73  ? 427 TYR A CZ  1 
ATOM   2994 O OH  . TYR A 1 427 ? -6.820  -40.731 -7.412  1.00 89.10  ? 427 TYR A OH  1 
ATOM   2995 N N   . ASN A 1 428 ? -11.361 -43.352 -5.644  1.00 63.57  ? 428 ASN A N   1 
ATOM   2996 C CA  . ASN A 1 428 ? -11.017 -43.590 -4.245  1.00 75.91  ? 428 ASN A CA  1 
ATOM   2997 C C   . ASN A 1 428 ? -9.790  -42.761 -3.891  1.00 82.08  ? 428 ASN A C   1 
ATOM   2998 O O   . ASN A 1 428 ? -8.723  -42.954 -4.482  1.00 79.66  ? 428 ASN A O   1 
ATOM   2999 C CB  . ASN A 1 428 ? -10.775 -45.086 -4.008  1.00 70.98  ? 428 ASN A CB  1 
ATOM   3000 C CG  . ASN A 1 428 ? -10.822 -45.465 -2.547  1.00 74.21  ? 428 ASN A CG  1 
ATOM   3001 O OD1 . ASN A 1 428 ? -10.149 -44.867 -1.702  1.00 79.35  ? 428 ASN A OD1 1 
ATOM   3002 N ND2 . ASN A 1 428 ? -11.677 -46.429 -2.230  1.00 69.68  ? 428 ASN A ND2 1 
ATOM   3003 N N   . ASP A 1 429 ? -9.933  -41.829 -2.936  1.00 82.06  ? 429 ASP A N   1 
ATOM   3004 C CA  . ASP A 1 429 ? -8.814  -40.939 -2.631  1.00 83.94  ? 429 ASP A CA  1 
ATOM   3005 C C   . ASP A 1 429 ? -7.897  -41.508 -1.554  1.00 91.23  ? 429 ASP A C   1 
ATOM   3006 O O   . ASP A 1 429 ? -6.714  -41.144 -1.511  1.00 90.86  ? 429 ASP A O   1 
ATOM   3007 C CB  . ASP A 1 429 ? -9.304  -39.538 -2.203  1.00 84.86  ? 429 ASP A CB  1 
ATOM   3008 C CG  . ASP A 1 429 ? -9.836  -39.486 -0.753  1.00 94.22  ? 429 ASP A CG  1 
ATOM   3009 O OD1 . ASP A 1 429 ? -8.994  -39.399 0.178   1.00 88.45  ? 429 ASP A OD1 1 
ATOM   3010 O OD2 . ASP A 1 429 ? -11.076 -39.516 -0.534  1.00 92.38  ? 429 ASP A OD2 1 
ATOM   3011 N N   . GLN A 1 430 ? -8.410  -42.386 -0.675  1.00 91.09  ? 430 GLN A N   1 
ATOM   3012 C CA  . GLN A 1 430 ? -7.547  -42.994 0.333   1.00 82.66  ? 430 GLN A CA  1 
ATOM   3013 C C   . GLN A 1 430 ? -6.495  -43.892 -0.298  1.00 84.68  ? 430 GLN A C   1 
ATOM   3014 O O   . GLN A 1 430 ? -5.502  -44.201 0.370   1.00 89.55  ? 430 GLN A O   1 
ATOM   3015 C CB  . GLN A 1 430 ? -8.324  -43.843 1.356   1.00 85.06  ? 430 GLN A CB  1 
ATOM   3016 C CG  . GLN A 1 430 ? -9.048  -43.144 2.524   1.00 96.01  ? 430 GLN A CG  1 
ATOM   3017 C CD  . GLN A 1 430 ? -10.528 -42.820 2.250   1.00 100.92 ? 430 GLN A CD  1 
ATOM   3018 O OE1 . GLN A 1 430 ? -10.957 -41.658 2.281   1.00 95.28  ? 430 GLN A OE1 1 
ATOM   3019 N NE2 . GLN A 1 430 ? -11.317 -43.864 2.003   1.00 88.81  ? 430 GLN A NE2 1 
ATOM   3020 N N   . THR A 1 431 ? -6.705  -44.348 -1.552  1.00 80.37  ? 431 THR A N   1 
ATOM   3021 C CA  . THR A 1 431 ? -5.849  -45.373 -2.165  1.00 74.08  ? 431 THR A CA  1 
ATOM   3022 C C   . THR A 1 431 ? -5.837  -45.277 -3.694  1.00 70.02  ? 431 THR A C   1 
ATOM   3023 O O   . THR A 1 431 ? -5.747  -46.298 -4.379  1.00 56.69  ? 431 THR A O   1 
ATOM   3024 C CB  . THR A 1 431 ? -6.283  -46.796 -1.780  1.00 70.41  ? 431 THR A CB  1 
ATOM   3025 O OG1 . THR A 1 431 ? -7.563  -47.078 -2.362  1.00 72.89  ? 431 THR A OG1 1 
ATOM   3026 C CG2 . THR A 1 431 ? -6.324  -47.041 -0.249  1.00 73.26  ? 431 THR A CG2 1 
ATOM   3027 N N   . ASP A 1 432 ? -5.924  -44.065 -4.245  1.00 78.86  ? 432 ASP A N   1 
ATOM   3028 C CA  . ASP A 1 432 ? -5.711  -43.799 -5.673  1.00 74.01  ? 432 ASP A CA  1 
ATOM   3029 C C   . ASP A 1 432 ? -5.954  -44.927 -6.676  1.00 73.56  ? 432 ASP A C   1 
ATOM   3030 O O   . ASP A 1 432 ? -4.993  -45.353 -7.318  1.00 83.23  ? 432 ASP A O   1 
ATOM   3031 C CB  . ASP A 1 432 ? -4.267  -43.317 -5.902  1.00 76.55  ? 432 ASP A CB  1 
ATOM   3032 C CG  . ASP A 1 432 ? -4.115  -41.794 -5.818  1.00 96.63  ? 432 ASP A CG  1 
ATOM   3033 O OD1 . ASP A 1 432 ? -4.721  -41.108 -6.678  1.00 97.84  ? 432 ASP A OD1 1 
ATOM   3034 O OD2 . ASP A 1 432 ? -3.395  -41.284 -4.916  1.00 94.99  ? 432 ASP A OD2 1 
ATOM   3035 N N   . GLU A 1 433 ? -7.187  -45.425 -6.851  1.00 76.66  ? 433 GLU A N   1 
ATOM   3036 C CA  . GLU A 1 433 ? -7.463  -46.266 -8.021  1.00 70.96  ? 433 GLU A CA  1 
ATOM   3037 C C   . GLU A 1 433 ? -8.974  -46.341 -8.289  1.00 66.63  ? 433 GLU A C   1 
ATOM   3038 O O   . GLU A 1 433 ? -9.790  -46.444 -7.362  1.00 55.38  ? 433 GLU A O   1 
ATOM   3039 C CB  . GLU A 1 433 ? -6.848  -47.692 -7.902  1.00 68.36  ? 433 GLU A CB  1 
ATOM   3040 C CG  . GLU A 1 433 ? -7.705  -48.883 -7.379  1.00 69.69  ? 433 GLU A CG  1 
ATOM   3041 C CD  . GLU A 1 433 ? -7.798  -49.034 -5.854  1.00 76.76  ? 433 GLU A CD  1 
ATOM   3042 O OE1 . GLU A 1 433 ? -7.907  -50.193 -5.367  1.00 61.50  ? 433 GLU A OE1 1 
ATOM   3043 O OE2 . GLU A 1 433 ? -7.832  -48.002 -5.147  1.00 82.09  ? 433 GLU A OE2 1 
ATOM   3044 N N   . ALA A 1 434 ? -9.325  -46.314 -9.578  1.00 67.59  ? 434 ALA A N   1 
ATOM   3045 C CA  . ALA A 1 434 ? -10.699 -46.237 -10.058 1.00 54.93  ? 434 ALA A CA  1 
ATOM   3046 C C   . ALA A 1 434 ? -11.262 -47.615 -10.404 1.00 61.70  ? 434 ALA A C   1 
ATOM   3047 O O   . ALA A 1 434 ? -10.529 -48.537 -10.778 1.00 63.16  ? 434 ALA A O   1 
ATOM   3048 C CB  . ALA A 1 434 ? -10.784 -45.330 -11.287 1.00 58.37  ? 434 ALA A CB  1 
ATOM   3049 N N   . SER A 1 435 ? -12.591 -47.724 -10.310 1.00 56.47  ? 435 SER A N   1 
ATOM   3050 C CA  . SER A 1 435 ? -13.314 -48.985 -10.392 1.00 48.91  ? 435 SER A CA  1 
ATOM   3051 C C   . SER A 1 435 ? -14.699 -48.708 -10.962 1.00 55.36  ? 435 SER A C   1 
ATOM   3052 O O   . SER A 1 435 ? -15.037 -47.563 -11.274 1.00 56.84  ? 435 SER A O   1 
ATOM   3053 C CB  . SER A 1 435 ? -13.420 -49.636 -9.012  1.00 50.27  ? 435 SER A CB  1 
ATOM   3054 O OG  . SER A 1 435 ? -14.246 -48.866 -8.156  1.00 44.56  ? 435 SER A OG  1 
ATOM   3055 N N   . THR A 1 436 ? -15.509 -49.774 -11.109 1.00 55.85  ? 436 THR A N   1 
ATOM   3056 C CA  . THR A 1 436 ? -16.931 -49.637 -11.407 1.00 43.18  ? 436 THR A CA  1 
ATOM   3057 C C   . THR A 1 436 ? -17.731 -50.572 -10.512 1.00 40.67  ? 436 THR A C   1 
ATOM   3058 O O   . THR A 1 436 ? -17.246 -51.613 -10.081 1.00 42.62  ? 436 THR A O   1 
ATOM   3059 C CB  . THR A 1 436 ? -17.289 -49.941 -12.878 1.00 49.00  ? 436 THR A CB  1 
ATOM   3060 O OG1 . THR A 1 436 ? -17.478 -51.345 -13.032 1.00 62.27  ? 436 THR A OG1 1 
ATOM   3061 C CG2 . THR A 1 436 ? -16.204 -49.466 -13.868 1.00 49.76  ? 436 THR A CG2 1 
ATOM   3062 N N   . GLN A 1 437 ? -18.952 -50.162 -10.209 1.00 43.57  ? 437 GLN A N   1 
ATOM   3063 C CA  . GLN A 1 437 ? -19.936 -50.964 -9.497  1.00 46.39  ? 437 GLN A CA  1 
ATOM   3064 C C   . GLN A 1 437 ? -21.228 -50.792 -10.277 1.00 50.30  ? 437 GLN A C   1 
ATOM   3065 O O   . GLN A 1 437 ? -21.587 -49.667 -10.642 1.00 50.59  ? 437 GLN A O   1 
ATOM   3066 C CB  . GLN A 1 437 ? -20.092 -50.533 -8.029  1.00 39.77  ? 437 GLN A CB  1 
ATOM   3067 C CG  . GLN A 1 437 ? -19.219 -51.321 -7.054  1.00 40.54  ? 437 GLN A CG  1 
ATOM   3068 C CD  . GLN A 1 437 ? -19.540 -51.027 -5.596  1.00 49.57  ? 437 GLN A CD  1 
ATOM   3069 O OE1 . GLN A 1 437 ? -19.288 -49.926 -5.125  1.00 62.53  ? 437 GLN A OE1 1 
ATOM   3070 N NE2 . GLN A 1 437 ? -20.053 -52.004 -4.873  1.00 52.90  ? 437 GLN A NE2 1 
ATOM   3071 N N   . THR A 1 438 ? -21.885 -51.902 -10.611 1.00 52.04  ? 438 THR A N   1 
ATOM   3072 C CA  . THR A 1 438 ? -23.009 -51.833 -11.528 1.00 51.81  ? 438 THR A CA  1 
ATOM   3073 C C   . THR A 1 438 ? -24.215 -52.530 -10.914 1.00 45.01  ? 438 THR A C   1 
ATOM   3074 O O   . THR A 1 438 ? -24.108 -53.316 -9.972  1.00 43.85  ? 438 THR A O   1 
ATOM   3075 C CB  . THR A 1 438 ? -22.679 -52.449 -12.905 1.00 48.62  ? 438 THR A CB  1 
ATOM   3076 O OG1 . THR A 1 438 ? -22.859 -53.853 -12.832 1.00 52.10  ? 438 THR A OG1 1 
ATOM   3077 C CG2 . THR A 1 438 ? -21.217 -52.180 -13.326 1.00 43.91  ? 438 THR A CG2 1 
ATOM   3078 N N   . TYR A 1 439 ? -25.373 -52.171 -11.431 1.00 48.52  ? 439 TYR A N   1 
ATOM   3079 C CA  . TYR A 1 439 ? -26.640 -52.809 -11.122 1.00 50.17  ? 439 TYR A CA  1 
ATOM   3080 C C   . TYR A 1 439 ? -27.252 -53.316 -12.422 1.00 55.12  ? 439 TYR A C   1 
ATOM   3081 O O   . TYR A 1 439 ? -27.259 -52.605 -13.440 1.00 55.43  ? 439 TYR A O   1 
ATOM   3082 C CB  . TYR A 1 439 ? -27.602 -51.836 -10.435 1.00 48.70  ? 439 TYR A CB  1 
ATOM   3083 C CG  . TYR A 1 439 ? -29.058 -52.121 -10.726 1.00 45.61  ? 439 TYR A CG  1 
ATOM   3084 C CD1 . TYR A 1 439 ? -29.668 -51.592 -11.844 1.00 45.12  ? 439 TYR A CD1 1 
ATOM   3085 C CD2 . TYR A 1 439 ? -29.824 -52.885 -9.869  1.00 46.29  ? 439 TYR A CD2 1 
ATOM   3086 C CE1 . TYR A 1 439 ? -30.981 -51.838 -12.120 1.00 51.27  ? 439 TYR A CE1 1 
ATOM   3087 C CE2 . TYR A 1 439 ? -31.152 -53.134 -10.133 1.00 48.55  ? 439 TYR A CE2 1 
ATOM   3088 C CZ  . TYR A 1 439 ? -31.733 -52.604 -11.268 1.00 50.46  ? 439 TYR A CZ  1 
ATOM   3089 O OH  . TYR A 1 439 ? -33.067 -52.843 -11.566 1.00 48.56  ? 439 TYR A OH  1 
ATOM   3090 N N   . ASP A 1 440 ? -27.789 -54.535 -12.378 1.00 56.85  ? 440 ASP A N   1 
ATOM   3091 C CA  . ASP A 1 440 ? -28.343 -55.190 -13.555 1.00 55.92  ? 440 ASP A CA  1 
ATOM   3092 C C   . ASP A 1 440 ? -29.713 -55.747 -13.217 1.00 52.03  ? 440 ASP A C   1 
ATOM   3093 O O   . ASP A 1 440 ? -29.851 -56.519 -12.267 1.00 55.64  ? 440 ASP A O   1 
ATOM   3094 C CB  . ASP A 1 440 ? -27.427 -56.311 -14.046 1.00 57.13  ? 440 ASP A CB  1 
ATOM   3095 C CG  . ASP A 1 440 ? -27.583 -56.565 -15.520 1.00 62.60  ? 440 ASP A CG  1 
ATOM   3096 O OD1 . ASP A 1 440 ? -28.550 -57.264 -15.896 1.00 69.98  ? 440 ASP A OD1 1 
ATOM   3097 O OD2 . ASP A 1 440 ? -26.744 -56.060 -16.301 1.00 59.39  ? 440 ASP A OD2 1 
ATOM   3098 N N   . SER A 1 441 ? -30.724 -55.351 -13.991 1.00 56.36  ? 441 SER A N   1 
ATOM   3099 C CA  . SER A 1 441 ? -32.080 -55.828 -13.745 1.00 60.79  ? 441 SER A CA  1 
ATOM   3100 C C   . SER A 1 441 ? -32.159 -57.352 -13.796 1.00 71.74  ? 441 SER A C   1 
ATOM   3101 O O   . SER A 1 441 ? -33.083 -57.935 -13.204 1.00 72.20  ? 441 SER A O   1 
ATOM   3102 C CB  . SER A 1 441 ? -33.051 -55.204 -14.756 1.00 62.57  ? 441 SER A CB  1 
ATOM   3103 O OG  . SER A 1 441 ? -32.784 -55.614 -16.093 1.00 65.38  ? 441 SER A OG  1 
ATOM   3104 N N   . LYS A 1 442 ? -31.193 -57.995 -14.478 1.00 73.59  ? 442 LYS A N   1 
ATOM   3105 C CA  . LYS A 1 442 ? -31.000 -59.441 -14.589 1.00 71.73  ? 442 LYS A CA  1 
ATOM   3106 C C   . LYS A 1 442 ? -31.911 -60.082 -15.644 1.00 75.17  ? 442 LYS A C   1 
ATOM   3107 O O   . LYS A 1 442 ? -32.043 -61.317 -15.663 1.00 80.28  ? 442 LYS A O   1 
ATOM   3108 C CB  . LYS A 1 442 ? -31.180 -60.141 -13.235 1.00 67.76  ? 442 LYS A CB  1 
ATOM   3109 C CG  . LYS A 1 442 ? -30.049 -59.917 -12.220 1.00 71.62  ? 442 LYS A CG  1 
ATOM   3110 C CD  . LYS A 1 442 ? -28.764 -60.709 -12.482 1.00 79.43  ? 442 LYS A CD  1 
ATOM   3111 C CE  . LYS A 1 442 ? -27.636 -60.268 -11.526 1.00 76.17  ? 442 LYS A CE  1 
ATOM   3112 N NZ  . LYS A 1 442 ? -26.535 -61.266 -11.371 1.00 88.21  ? 442 LYS A NZ  1 
ATOM   3113 N N   . ARG A 1 443 ? -32.528 -59.287 -16.542 1.00 71.50  ? 443 ARG A N   1 
ATOM   3114 C CA  . ARG A 1 443 ? -33.466 -59.774 -17.560 1.00 71.73  ? 443 ARG A CA  1 
ATOM   3115 C C   . ARG A 1 443 ? -33.813 -58.651 -18.547 1.00 71.02  ? 443 ARG A C   1 
ATOM   3116 O O   . ARG A 1 443 ? -34.586 -57.735 -18.221 1.00 65.04  ? 443 ARG A O   1 
ATOM   3117 C CB  A ARG A 1 443 ? -34.712 -60.354 -16.872 0.59 74.97  ? 443 ARG A CB  1 
ATOM   3118 C CB  B ARG A 1 443 ? -34.713 -60.357 -16.877 0.41 74.99  ? 443 ARG A CB  1 
ATOM   3119 C CG  A ARG A 1 443 ? -35.784 -61.078 -17.722 0.59 73.24  ? 443 ARG A CG  1 
ATOM   3120 C CG  B ARG A 1 443 ? -35.410 -61.528 -17.607 0.41 74.23  ? 443 ARG A CG  1 
ATOM   3121 C CD  A ARG A 1 443 ? -36.557 -61.958 -16.710 0.59 75.24  ? 443 ARG A CD  1 
ATOM   3122 C CD  B ARG A 1 443 ? -36.358 -62.312 -16.668 0.41 74.86  ? 443 ARG A CD  1 
ATOM   3123 N NE  A ARG A 1 443 ? -37.742 -62.680 -17.165 0.59 74.92  ? 443 ARG A NE  1 
ATOM   3124 N NE  B ARG A 1 443 ? -36.763 -61.557 -15.479 0.41 73.82  ? 443 ARG A NE  1 
ATOM   3125 C CZ  A ARG A 1 443 ? -38.656 -63.165 -16.324 0.59 75.49  ? 443 ARG A CZ  1 
ATOM   3126 C CZ  B ARG A 1 443 ? -37.648 -61.984 -14.583 0.41 70.32  ? 443 ARG A CZ  1 
ATOM   3127 N NH1 A ARG A 1 443 ? -38.504 -62.992 -15.011 0.59 72.43  ? 443 ARG A NH1 1 
ATOM   3128 N NH1 B ARG A 1 443 ? -37.956 -61.231 -13.543 0.41 68.59  ? 443 ARG A NH1 1 
ATOM   3129 N NH2 A ARG A 1 443 ? -39.722 -63.814 -16.779 0.59 72.10  ? 443 ARG A NH2 1 
ATOM   3130 N NH2 B ARG A 1 443 ? -38.215 -63.172 -14.720 0.41 72.08  ? 443 ARG A NH2 1 
ATOM   3131 N N   . ASN A 1 444 ? -33.153 -58.695 -19.727 1.00 66.64  ? 444 ASN A N   1 
ATOM   3132 C CA  . ASN A 1 444 ? -33.351 -57.843 -20.908 1.00 60.07  ? 444 ASN A CA  1 
ATOM   3133 C C   . ASN A 1 444 ? -32.929 -56.386 -20.738 1.00 60.71  ? 444 ASN A C   1 
ATOM   3134 O O   . ASN A 1 444 ? -33.742 -55.476 -20.913 1.00 61.33  ? 444 ASN A O   1 
ATOM   3135 C CB  . ASN A 1 444 ? -34.813 -57.883 -21.366 1.00 67.80  ? 444 ASN A CB  1 
ATOM   3136 C CG  . ASN A 1 444 ? -35.010 -57.280 -22.761 1.00 67.08  ? 444 ASN A CG  1 
ATOM   3137 O OD1 . ASN A 1 444 ? -34.044 -56.882 -23.423 1.00 63.82  ? 444 ASN A OD1 1 
ATOM   3138 N ND2 . ASN A 1 444 ? -36.264 -57.205 -23.205 1.00 65.32  ? 444 ASN A ND2 1 
ATOM   3139 N N   . VAL A 1 445 ? -31.642 -56.151 -20.507 1.00 58.28  ? 445 VAL A N   1 
ATOM   3140 C CA  . VAL A 1 445 ? -31.189 -54.844 -20.046 1.00 51.26  ? 445 VAL A CA  1 
ATOM   3141 C C   . VAL A 1 445 ? -31.497 -53.748 -21.060 1.00 56.01  ? 445 VAL A C   1 
ATOM   3142 O O   . VAL A 1 445 ? -31.860 -52.625 -20.690 1.00 60.73  ? 445 VAL A O   1 
ATOM   3143 C CB  . VAL A 1 445 ? -29.695 -54.910 -19.713 1.00 52.45  ? 445 VAL A CB  1 
ATOM   3144 C CG1 . VAL A 1 445 ? -29.104 -53.544 -19.754 1.00 63.91  ? 445 VAL A CG1 1 
ATOM   3145 C CG2 . VAL A 1 445 ? -29.529 -55.515 -18.333 1.00 56.59  ? 445 VAL A CG2 1 
ATOM   3146 N N   . GLY A 1 446 ? -31.364 -54.032 -22.335 1.00 54.73  ? 446 GLY A N   1 
ATOM   3147 C CA  . GLY A 1 446 ? -31.578 -52.986 -23.311 1.00 53.90  ? 446 GLY A CA  1 
ATOM   3148 C C   . GLY A 1 446 ? -30.302 -52.222 -23.591 1.00 51.85  ? 446 GLY A C   1 
ATOM   3149 O O   . GLY A 1 446 ? -29.187 -52.713 -23.386 1.00 50.70  ? 446 GLY A O   1 
ATOM   3150 N N   . ALA A 1 447 ? -30.476 -50.995 -24.071 1.00 55.46  ? 447 ALA A N   1 
ATOM   3151 C CA  . ALA A 1 447 ? -29.358 -50.125 -24.408 1.00 58.08  ? 447 ALA A CA  1 
ATOM   3152 C C   . ALA A 1 447 ? -29.261 -48.943 -23.447 1.00 54.15  ? 447 ALA A C   1 
ATOM   3153 O O   . ALA A 1 447 ? -30.252 -48.513 -22.842 1.00 50.03  ? 447 ALA A O   1 
ATOM   3154 C CB  . ALA A 1 447 ? -29.480 -49.605 -25.842 1.00 52.22  ? 447 ALA A CB  1 
ATOM   3155 N N   . VAL A 1 448 ? -28.040 -48.409 -23.334 1.00 54.67  ? 448 VAL A N   1 
ATOM   3156 C CA  . VAL A 1 448 ? -27.815 -47.206 -22.536 1.00 57.23  ? 448 VAL A CA  1 
ATOM   3157 C C   . VAL A 1 448 ? -28.514 -46.030 -23.205 1.00 53.91  ? 448 VAL A C   1 
ATOM   3158 O O   . VAL A 1 448 ? -28.346 -45.795 -24.413 1.00 44.77  ? 448 VAL A O   1 
ATOM   3159 C CB  . VAL A 1 448 ? -26.311 -46.922 -22.348 1.00 44.89  ? 448 VAL A CB  1 
ATOM   3160 C CG1 . VAL A 1 448 ? -25.674 -47.938 -21.413 1.00 45.86  ? 448 VAL A CG1 1 
ATOM   3161 C CG2 . VAL A 1 448 ? -25.596 -46.881 -23.662 1.00 48.06  ? 448 VAL A CG2 1 
ATOM   3162 N N   . SER A 1 449 ? -29.308 -45.280 -22.411 1.00 50.11  ? 449 SER A N   1 
ATOM   3163 C CA  . SER A 1 449 ? -30.025 -44.110 -22.901 1.00 50.74  ? 449 SER A CA  1 
ATOM   3164 C C   . SER A 1 449 ? -29.793 -42.846 -22.086 1.00 49.49  ? 449 SER A C   1 
ATOM   3165 O O   . SER A 1 449 ? -30.369 -41.809 -22.422 1.00 55.31  ? 449 SER A O   1 
ATOM   3166 C CB  . SER A 1 449 ? -31.535 -44.377 -22.940 1.00 52.90  ? 449 SER A CB  1 
ATOM   3167 O OG  . SER A 1 449 ? -32.044 -44.551 -21.632 1.00 57.54  ? 449 SER A OG  1 
ATOM   3168 N N   . TRP A 1 450 ? -28.962 -42.891 -21.051 1.00 48.59  ? 450 TRP A N   1 
ATOM   3169 C CA  . TRP A 1 450 ? -28.869 -41.799 -20.085 1.00 48.77  ? 450 TRP A CA  1 
ATOM   3170 C C   . TRP A 1 450 ? -27.431 -41.705 -19.588 1.00 48.07  ? 450 TRP A C   1 
ATOM   3171 O O   . TRP A 1 450 ? -26.911 -42.676 -19.032 1.00 54.06  ? 450 TRP A O   1 
ATOM   3172 C CB  . TRP A 1 450 ? -29.844 -42.070 -18.938 1.00 50.02  ? 450 TRP A CB  1 
ATOM   3173 C CG  . TRP A 1 450 ? -30.153 -40.922 -18.035 1.00 52.08  ? 450 TRP A CG  1 
ATOM   3174 C CD1 . TRP A 1 450 ? -31.179 -40.027 -18.161 1.00 49.57  ? 450 TRP A CD1 1 
ATOM   3175 C CD2 . TRP A 1 450 ? -29.467 -40.573 -16.827 1.00 50.12  ? 450 TRP A CD2 1 
ATOM   3176 N NE1 . TRP A 1 450 ? -31.163 -39.139 -17.114 1.00 44.62  ? 450 TRP A NE1 1 
ATOM   3177 C CE2 . TRP A 1 450 ? -30.119 -39.452 -16.285 1.00 48.48  ? 450 TRP A CE2 1 
ATOM   3178 C CE3 . TRP A 1 450 ? -28.359 -41.094 -16.158 1.00 51.58  ? 450 TRP A CE3 1 
ATOM   3179 C CZ2 . TRP A 1 450 ? -29.699 -38.848 -15.115 1.00 49.51  ? 450 TRP A CZ2 1 
ATOM   3180 C CZ3 . TRP A 1 450 ? -27.944 -40.492 -14.997 1.00 50.41  ? 450 TRP A CZ3 1 
ATOM   3181 C CH2 . TRP A 1 450 ? -28.609 -39.384 -14.487 1.00 50.06  ? 450 TRP A CH2 1 
ATOM   3182 N N   . ASP A 1 451 ? -26.774 -40.563 -19.800 1.00 46.91  ? 451 ASP A N   1 
ATOM   3183 C CA  . ASP A 1 451 ? -25.358 -40.404 -19.462 1.00 51.94  ? 451 ASP A CA  1 
ATOM   3184 C C   . ASP A 1 451 ? -25.198 -39.131 -18.642 1.00 55.16  ? 451 ASP A C   1 
ATOM   3185 O O   . ASP A 1 451 ? -25.414 -38.030 -19.158 1.00 51.46  ? 451 ASP A O   1 
ATOM   3186 C CB  . ASP A 1 451 ? -24.487 -40.362 -20.724 1.00 55.55  ? 451 ASP A CB  1 
ATOM   3187 C CG  . ASP A 1 451 ? -23.005 -40.637 -20.443 1.00 60.61  ? 451 ASP A CG  1 
ATOM   3188 O OD1 . ASP A 1 451 ? -22.610 -40.638 -19.256 1.00 62.65  ? 451 ASP A OD1 1 
ATOM   3189 O OD2 . ASP A 1 451 ? -22.228 -40.853 -21.410 1.00 59.61  ? 451 ASP A OD2 1 
ATOM   3190 N N   . SER A 1 452 ? -24.812 -39.280 -17.365 1.00 57.18  ? 452 SER A N   1 
ATOM   3191 C CA  . SER A 1 452 ? -24.762 -38.129 -16.468 1.00 52.06  ? 452 SER A CA  1 
ATOM   3192 C C   . SER A 1 452 ? -23.724 -37.101 -16.912 1.00 49.55  ? 452 SER A C   1 
ATOM   3193 O O   . SER A 1 452 ? -23.850 -35.925 -16.553 1.00 47.01  ? 452 SER A O   1 
ATOM   3194 C CB  . SER A 1 452 ? -24.529 -38.600 -15.021 1.00 44.69  ? 452 SER A CB  1 
ATOM   3195 O OG  . SER A 1 452 ? -23.171 -38.863 -14.739 1.00 46.00  ? 452 SER A OG  1 
ATOM   3196 N N   . ILE A 1 453 ? -22.746 -37.515 -17.730 1.00 52.90  ? 453 ILE A N   1 
ATOM   3197 C CA  . ILE A 1 453 ? -21.771 -36.607 -18.343 1.00 51.68  ? 453 ILE A CA  1 
ATOM   3198 C C   . ILE A 1 453 ? -22.443 -35.574 -19.242 1.00 51.54  ? 453 ILE A C   1 
ATOM   3199 O O   . ILE A 1 453 ? -21.951 -34.448 -19.389 1.00 53.48  ? 453 ILE A O   1 
ATOM   3200 C CB  . ILE A 1 453 ? -20.724 -37.447 -19.105 1.00 50.75  ? 453 ILE A CB  1 
ATOM   3201 C CG1 . ILE A 1 453 ? -19.891 -38.208 -18.097 1.00 55.03  ? 453 ILE A CG1 1 
ATOM   3202 C CG2 . ILE A 1 453 ? -19.831 -36.607 -19.984 1.00 49.50  ? 453 ILE A CG2 1 
ATOM   3203 C CD1 . ILE A 1 453 ? -19.438 -37.326 -16.948 1.00 58.55  ? 453 ILE A CD1 1 
ATOM   3204 N N   . ASP A 1 454 ? -23.572 -35.929 -19.852 1.00 52.87  ? 454 ASP A N   1 
ATOM   3205 C CA  . ASP A 1 454 ? -24.312 -35.014 -20.711 1.00 56.25  ? 454 ASP A CA  1 
ATOM   3206 C C   . ASP A 1 454 ? -24.966 -33.885 -19.929 1.00 57.17  ? 454 ASP A C   1 
ATOM   3207 O O   . ASP A 1 454 ? -25.543 -32.977 -20.535 1.00 66.42  ? 454 ASP A O   1 
ATOM   3208 C CB  . ASP A 1 454 ? -25.376 -35.793 -21.500 1.00 58.51  ? 454 ASP A CB  1 
ATOM   3209 C CG  . ASP A 1 454 ? -24.765 -36.911 -22.384 1.00 67.25  ? 454 ASP A CG  1 
ATOM   3210 O OD1 . ASP A 1 454 ? -23.668 -36.702 -22.964 1.00 63.52  ? 454 ASP A OD1 1 
ATOM   3211 O OD2 . ASP A 1 454 ? -25.390 -37.999 -22.504 1.00 67.66  ? 454 ASP A OD2 1 
ATOM   3212 N N   . GLN A 1 455 ? -24.893 -33.924 -18.601 1.00 52.37  ? 455 GLN A N   1 
ATOM   3213 C CA  . GLN A 1 455 ? -25.578 -32.950 -17.767 1.00 46.28  ? 455 GLN A CA  1 
ATOM   3214 C C   . GLN A 1 455 ? -24.655 -32.359 -16.726 1.00 47.60  ? 455 GLN A C   1 
ATOM   3215 O O   . GLN A 1 455 ? -24.781 -31.177 -16.394 1.00 51.62  ? 455 GLN A O   1 
ATOM   3216 C CB  . GLN A 1 455 ? -26.765 -33.588 -17.081 1.00 41.84  ? 455 GLN A CB  1 
ATOM   3217 C CG  . GLN A 1 455 ? -27.737 -34.130 -18.047 1.00 44.57  ? 455 GLN A CG  1 
ATOM   3218 C CD  . GLN A 1 455 ? -28.856 -34.795 -17.351 1.00 46.28  ? 455 GLN A CD  1 
ATOM   3219 O OE1 . GLN A 1 455 ? -29.855 -34.157 -17.024 1.00 47.17  ? 455 GLN A OE1 1 
ATOM   3220 N NE2 . GLN A 1 455 ? -28.702 -36.090 -17.090 1.00 49.72  ? 455 GLN A NE2 1 
ATOM   3221 N N   . LEU A 1 456 ? -23.741 -33.175 -16.197 1.00 46.97  ? 456 LEU A N   1 
ATOM   3222 C CA  . LEU A 1 456 ? -22.697 -32.728 -15.277 1.00 44.67  ? 456 LEU A CA  1 
ATOM   3223 C C   . LEU A 1 456 ? -21.342 -33.022 -15.912 1.00 47.89  ? 456 LEU A C   1 
ATOM   3224 O O   . LEU A 1 456 ? -20.632 -33.945 -15.484 1.00 52.04  ? 456 LEU A O   1 
ATOM   3225 C CB  . LEU A 1 456 ? -22.823 -33.417 -13.921 1.00 38.86  ? 456 LEU A CB  1 
ATOM   3226 C CG  . LEU A 1 456 ? -24.180 -33.331 -13.224 1.00 35.94  ? 456 LEU A CG  1 
ATOM   3227 C CD1 . LEU A 1 456 ? -24.071 -33.897 -11.841 1.00 35.45  ? 456 LEU A CD1 1 
ATOM   3228 C CD2 . LEU A 1 456 ? -24.695 -31.906 -13.168 1.00 36.46  ? 456 LEU A CD2 1 
ATOM   3229 N N   . PRO A 1 457 ? -20.950 -32.261 -16.933 1.00 49.89  ? 457 PRO A N   1 
ATOM   3230 C CA  . PRO A 1 457 ? -19.720 -32.575 -17.659 1.00 58.44  ? 457 PRO A CA  1 
ATOM   3231 C C   . PRO A 1 457 ? -18.519 -32.594 -16.726 1.00 66.48  ? 457 PRO A C   1 
ATOM   3232 O O   . PRO A 1 457 ? -18.642 -32.360 -15.513 1.00 62.85  ? 457 PRO A O   1 
ATOM   3233 C CB  . PRO A 1 457 ? -19.616 -31.433 -18.681 1.00 55.40  ? 457 PRO A CB  1 
ATOM   3234 C CG  . PRO A 1 457 ? -20.960 -30.943 -18.857 1.00 57.76  ? 457 PRO A CG  1 
ATOM   3235 C CD  . PRO A 1 457 ? -21.708 -31.182 -17.592 1.00 52.13  ? 457 PRO A CD  1 
ATOM   3236 N N   . PRO A 1 458 ? -17.334 -32.894 -17.237 1.00 68.54  ? 458 PRO A N   1 
ATOM   3237 C CA  . PRO A 1 458 ? -16.128 -32.672 -16.441 1.00 70.63  ? 458 PRO A CA  1 
ATOM   3238 C C   . PRO A 1 458 ? -15.713 -31.198 -16.435 1.00 75.25  ? 458 PRO A C   1 
ATOM   3239 O O   . PRO A 1 458 ? -16.129 -30.393 -17.272 1.00 67.26  ? 458 PRO A O   1 
ATOM   3240 C CB  . PRO A 1 458 ? -15.082 -33.563 -17.133 1.00 75.01  ? 458 PRO A CB  1 
ATOM   3241 C CG  . PRO A 1 458 ? -15.846 -34.403 -18.140 1.00 66.36  ? 458 PRO A CG  1 
ATOM   3242 C CD  . PRO A 1 458 ? -17.039 -33.610 -18.493 1.00 66.75  ? 458 PRO A CD  1 
ATOM   3243 N N   . GLU A 1 459 ? -14.892 -30.853 -15.430 1.00 80.29  ? 459 GLU A N   1 
ATOM   3244 C CA  . GLU A 1 459 ? -14.257 -29.535 -15.358 1.00 74.37  ? 459 GLU A CA  1 
ATOM   3245 C C   . GLU A 1 459 ? -13.400 -29.274 -16.590 1.00 79.07  ? 459 GLU A C   1 
ATOM   3246 O O   . GLU A 1 459 ? -13.629 -28.314 -17.335 1.00 86.63  ? 459 GLU A O   1 
ATOM   3247 C CB  . GLU A 1 459 ? -13.386 -29.449 -14.108 1.00 74.16  ? 459 GLU A CB  1 
ATOM   3248 C CG  . GLU A 1 459 ? -14.121 -29.473 -12.791 1.00 67.87  ? 459 GLU A CG  1 
ATOM   3249 C CD  . GLU A 1 459 ? -13.165 -29.348 -11.617 1.00 75.54  ? 459 GLU A CD  1 
ATOM   3250 O OE1 . GLU A 1 459 ? -12.056 -28.793 -11.809 1.00 78.02  ? 459 GLU A OE1 1 
ATOM   3251 O OE2 . GLU A 1 459 ? -13.517 -29.810 -10.508 1.00 73.14  ? 459 GLU A OE2 1 
ATOM   3252 N N   . THR A 1 460 ? -12.372 -30.104 -16.793 1.00 81.33  ? 460 THR A N   1 
ATOM   3253 C CA  . THR A 1 460 ? -11.606 -30.158 -18.034 1.00 88.60  ? 460 THR A CA  1 
ATOM   3254 C C   . THR A 1 460 ? -11.625 -31.582 -18.577 1.00 85.19  ? 460 THR A C   1 
ATOM   3255 O O   . THR A 1 460 ? -11.667 -32.555 -17.817 1.00 82.59  ? 460 THR A O   1 
ATOM   3256 C CB  . THR A 1 460 ? -10.148 -29.705 -17.836 1.00 87.07  ? 460 THR A CB  1 
ATOM   3257 O OG1 . THR A 1 460 ? -9.477  -30.610 -16.940 1.00 78.56  ? 460 THR A OG1 1 
ATOM   3258 C CG2 . THR A 1 460 ? -10.091 -28.260 -17.301 1.00 86.01  ? 460 THR A CG2 1 
ATOM   3259 N N   . THR A 1 461 ? -11.611 -31.703 -19.903 1.00 81.91  ? 461 THR A N   1 
ATOM   3260 C CA  . THR A 1 461 ? -11.477 -33.007 -20.537 1.00 86.79  ? 461 THR A CA  1 
ATOM   3261 C C   . THR A 1 461 ? -10.027 -33.338 -20.887 1.00 89.13  ? 461 THR A C   1 
ATOM   3262 O O   . THR A 1 461 ? -9.783  -34.178 -21.761 1.00 91.25  ? 461 THR A O   1 
ATOM   3263 C CB  . THR A 1 461 ? -12.377 -33.097 -21.774 1.00 87.91  ? 461 THR A CB  1 
ATOM   3264 O OG1 . THR A 1 461 ? -12.306 -31.870 -22.514 1.00 84.47  ? 461 THR A OG1 1 
ATOM   3265 C CG2 . THR A 1 461 ? -13.825 -33.390 -21.376 1.00 89.59  ? 461 THR A CG2 1 
ATOM   3266 N N   . ASP A 1 462 ? -9.068  -32.697 -20.210 1.00 92.26  ? 462 ASP A N   1 
ATOM   3267 C CA  . ASP A 1 462 ? -7.646  -33.025 -20.295 1.00 87.48  ? 462 ASP A CA  1 
ATOM   3268 C C   . ASP A 1 462 ? -7.351  -34.371 -19.643 1.00 88.43  ? 462 ASP A C   1 
ATOM   3269 O O   . ASP A 1 462 ? -6.996  -35.342 -20.324 1.00 91.26  ? 462 ASP A O   1 
ATOM   3270 C CB  . ASP A 1 462 ? -6.804  -31.932 -19.625 1.00 81.04  ? 462 ASP A CB  1 
ATOM   3271 C CG  . ASP A 1 462 ? -6.065  -31.074 -20.625 1.00 84.13  ? 462 ASP A CG  1 
ATOM   3272 O OD1 . ASP A 1 462 ? -5.785  -31.576 -21.730 1.00 82.85  ? 462 ASP A OD1 1 
ATOM   3273 O OD2 . ASP A 1 462 ? -5.777  -29.897 -20.316 1.00 91.80  ? 462 ASP A OD2 1 
ATOM   3274 N N   . GLU A 1 463 ? -7.498  -34.427 -18.322 1.00 81.94  ? 463 GLU A N   1 
ATOM   3275 C CA  . GLU A 1 463 ? -7.167  -35.607 -17.555 1.00 82.12  ? 463 GLU A CA  1 
ATOM   3276 C C   . GLU A 1 463 ? -8.164  -36.724 -17.844 1.00 80.91  ? 463 GLU A C   1 
ATOM   3277 O O   . GLU A 1 463 ? -9.184  -36.504 -18.498 1.00 74.56  ? 463 GLU A O   1 
ATOM   3278 C CB  . GLU A 1 463 ? -7.197  -35.280 -16.068 1.00 90.04  ? 463 GLU A CB  1 
ATOM   3279 C CG  . GLU A 1 463 ? -6.277  -34.179 -15.612 1.00 91.41  ? 463 GLU A CG  1 
ATOM   3280 C CD  . GLU A 1 463 ? -6.771  -33.576 -14.308 1.00 91.30  ? 463 GLU A CD  1 
ATOM   3281 O OE1 . GLU A 1 463 ? -7.731  -32.759 -14.345 1.00 86.78  ? 463 GLU A OE1 1 
ATOM   3282 O OE2 . GLU A 1 463 ? -6.215  -33.947 -13.247 1.00 85.46  ? 463 GLU A OE2 1 
ATOM   3283 N N   . PRO A 1 464 ? -7.895  -37.944 -17.362 1.00 88.91  ? 464 PRO A N   1 
ATOM   3284 C CA  . PRO A 1 464 ? -8.959  -38.957 -17.298 1.00 90.33  ? 464 PRO A CA  1 
ATOM   3285 C C   . PRO A 1 464 ? -10.090 -38.517 -16.374 1.00 85.17  ? 464 PRO A C   1 
ATOM   3286 O O   . PRO A 1 464 ? -9.894  -37.731 -15.440 1.00 81.81  ? 464 PRO A O   1 
ATOM   3287 C CB  . PRO A 1 464 ? -8.242  -40.204 -16.757 1.00 87.13  ? 464 PRO A CB  1 
ATOM   3288 C CG  . PRO A 1 464 ? -6.957  -39.705 -16.155 1.00 87.68  ? 464 PRO A CG  1 
ATOM   3289 C CD  . PRO A 1 464 ? -6.586  -38.500 -16.972 1.00 90.11  ? 464 PRO A CD  1 
ATOM   3290 N N   . LEU A 1 465 ? -11.288 -39.051 -16.637 1.00 77.45  ? 465 LEU A N   1 
ATOM   3291 C CA  . LEU A 1 465 ? -12.494 -38.486 -16.044 1.00 72.60  ? 465 LEU A CA  1 
ATOM   3292 C C   . LEU A 1 465 ? -12.552 -38.683 -14.526 1.00 74.06  ? 465 LEU A C   1 
ATOM   3293 O O   . LEU A 1 465 ? -13.248 -37.918 -13.853 1.00 74.11  ? 465 LEU A O   1 
ATOM   3294 C CB  . LEU A 1 465 ? -13.738 -39.076 -16.740 1.00 69.20  ? 465 LEU A CB  1 
ATOM   3295 C CG  . LEU A 1 465 ? -15.112 -38.373 -16.823 1.00 61.52  ? 465 LEU A CG  1 
ATOM   3296 C CD1 . LEU A 1 465 ? -16.053 -39.156 -17.695 1.00 54.87  ? 465 LEU A CD1 1 
ATOM   3297 C CD2 . LEU A 1 465 ? -15.793 -38.138 -15.497 1.00 62.48  ? 465 LEU A CD2 1 
ATOM   3298 N N   . GLU A 1 466 ? -11.818 -39.651 -13.950 1.00 77.10  ? 466 GLU A N   1 
ATOM   3299 C CA  . GLU A 1 466 ? -11.872 -39.809 -12.494 1.00 74.90  ? 466 GLU A CA  1 
ATOM   3300 C C   . GLU A 1 466 ? -11.018 -38.777 -11.756 1.00 79.94  ? 466 GLU A C   1 
ATOM   3301 O O   . GLU A 1 466 ? -11.161 -38.641 -10.533 1.00 81.09  ? 466 GLU A O   1 
ATOM   3302 C CB  . GLU A 1 466 ? -11.431 -41.209 -12.040 1.00 76.94  ? 466 GLU A CB  1 
ATOM   3303 C CG  . GLU A 1 466 ? -9.915  -41.439 -11.956 1.00 83.53  ? 466 GLU A CG  1 
ATOM   3304 C CD  . GLU A 1 466 ? -9.282  -41.973 -13.232 1.00 87.18  ? 466 GLU A CD  1 
ATOM   3305 O OE1 . GLU A 1 466 ? -9.944  -41.946 -14.302 1.00 80.47  ? 466 GLU A OE1 1 
ATOM   3306 O OE2 . GLU A 1 466 ? -8.099  -42.392 -13.152 1.00 89.57  ? 466 GLU A OE2 1 
ATOM   3307 N N   . LYS A 1 467 ? -10.113 -38.075 -12.453 1.00 80.71  ? 467 LYS A N   1 
ATOM   3308 C CA  . LYS A 1 467 ? -9.465  -36.901 -11.872 1.00 82.71  ? 467 LYS A CA  1 
ATOM   3309 C C   . LYS A 1 467 ? -10.154 -35.591 -12.264 1.00 81.68  ? 467 LYS A C   1 
ATOM   3310 O O   . LYS A 1 467 ? -10.324 -34.712 -11.408 1.00 81.34  ? 467 LYS A O   1 
ATOM   3311 C CB  . LYS A 1 467 ? -7.971  -36.842 -12.243 1.00 86.39  ? 467 LYS A CB  1 
ATOM   3312 C CG  . LYS A 1 467 ? -7.071  -37.878 -11.534 1.00 95.88  ? 467 LYS A CG  1 
ATOM   3313 C CD  . LYS A 1 467 ? -5.654  -37.943 -12.136 1.00 98.91  ? 467 LYS A CD  1 
ATOM   3314 C CE  . LYS A 1 467 ? -4.909  -39.216 -11.721 1.00 88.15  ? 467 LYS A CE  1 
ATOM   3315 N NZ  . LYS A 1 467 ? -3.680  -39.409 -12.533 1.00 75.01  ? 467 LYS A NZ  1 
ATOM   3316 N N   . GLY A 1 468 ? -10.581 -35.446 -13.525 1.00 72.25  ? 468 GLY A N   1 
ATOM   3317 C CA  . GLY A 1 468 ? -11.169 -34.199 -13.989 1.00 72.35  ? 468 GLY A CA  1 
ATOM   3318 C C   . GLY A 1 468 ? -12.690 -34.111 -14.034 1.00 73.40  ? 468 GLY A C   1 
ATOM   3319 O O   . GLY A 1 468 ? -13.237 -33.284 -14.766 1.00 70.87  ? 468 GLY A O   1 
ATOM   3320 N N   . TYR A 1 469 ? -13.387 -34.936 -13.256 1.00 71.07  ? 469 TYR A N   1 
ATOM   3321 C CA  . TYR A 1 469 ? -14.839 -34.873 -13.196 1.00 61.93  ? 469 TYR A CA  1 
ATOM   3322 C C   . TYR A 1 469 ? -15.271 -33.629 -12.438 1.00 60.62  ? 469 TYR A C   1 
ATOM   3323 O O   . TYR A 1 469 ? -14.462 -32.962 -11.791 1.00 67.11  ? 469 TYR A O   1 
ATOM   3324 C CB  . TYR A 1 469 ? -15.400 -36.122 -12.517 1.00 56.87  ? 469 TYR A CB  1 
ATOM   3325 C CG  . TYR A 1 469 ? -15.129 -36.253 -11.017 1.00 58.36  ? 469 TYR A CG  1 
ATOM   3326 C CD1 . TYR A 1 469 ? -15.917 -35.591 -10.070 1.00 55.06  ? 469 TYR A CD1 1 
ATOM   3327 C CD2 . TYR A 1 469 ? -14.105 -37.066 -10.548 1.00 62.03  ? 469 TYR A CD2 1 
ATOM   3328 C CE1 . TYR A 1 469 ? -15.684 -35.738 -8.704  1.00 53.45  ? 469 TYR A CE1 1 
ATOM   3329 C CE2 . TYR A 1 469 ? -13.869 -37.222 -9.183  1.00 61.82  ? 469 TYR A CE2 1 
ATOM   3330 C CZ  . TYR A 1 469 ? -14.655 -36.553 -8.264  1.00 57.54  ? 469 TYR A CZ  1 
ATOM   3331 O OH  . TYR A 1 469 ? -14.402 -36.707 -6.913  1.00 54.29  ? 469 TYR A OH  1 
ATOM   3332 N N   . SER A 1 470 ? -16.577 -33.337 -12.466 1.00 58.45  ? 470 SER A N   1 
ATOM   3333 C CA  . SER A 1 470 ? -17.067 -32.185 -11.719 1.00 55.89  ? 470 SER A CA  1 
ATOM   3334 C C   . SER A 1 470 ? -18.017 -32.508 -10.569 1.00 48.74  ? 470 SER A C   1 
ATOM   3335 O O   . SER A 1 470 ? -18.179 -31.660 -9.690  1.00 47.31  ? 470 SER A O   1 
ATOM   3336 C CB  . SER A 1 470 ? -17.755 -31.181 -12.651 1.00 53.11  ? 470 SER A CB  1 
ATOM   3337 O OG  . SER A 1 470 ? -19.131 -31.460 -12.788 1.00 48.54  ? 470 SER A OG  1 
ATOM   3338 N N   . HIS A 1 471 ? -18.654 -33.677 -10.535 1.00 43.39  ? 471 HIS A N   1 
ATOM   3339 C CA  . HIS A 1 471 ? -19.606 -33.949 -9.463  1.00 43.76  ? 471 HIS A CA  1 
ATOM   3340 C C   . HIS A 1 471 ? -19.540 -35.405 -9.041  1.00 45.33  ? 471 HIS A C   1 
ATOM   3341 O O   . HIS A 1 471 ? -19.182 -36.287 -9.824  1.00 45.43  ? 471 HIS A O   1 
ATOM   3342 C CB  . HIS A 1 471 ? -21.056 -33.655 -9.865  1.00 41.51  ? 471 HIS A CB  1 
ATOM   3343 C CG  . HIS A 1 471 ? -21.387 -32.201 -9.977  1.00 39.64  ? 471 HIS A CG  1 
ATOM   3344 N ND1 . HIS A 1 471 ? -20.751 -31.353 -10.859 1.00 44.53  ? 471 HIS A ND1 1 
ATOM   3345 C CD2 . HIS A 1 471 ? -22.357 -31.467 -9.387  1.00 38.58  ? 471 HIS A CD2 1 
ATOM   3346 C CE1 . HIS A 1 471 ? -21.284 -30.147 -10.771 1.00 44.45  ? 471 HIS A CE1 1 
ATOM   3347 N NE2 . HIS A 1 471 ? -22.265 -30.191 -9.887  1.00 38.67  ? 471 HIS A NE2 1 
ATOM   3348 N N   . GLN A 1 472 ? -19.951 -35.645 -7.797  1.00 44.00  ? 472 GLN A N   1 
ATOM   3349 C CA  . GLN A 1 472 ? -20.080 -36.981 -7.240  1.00 41.14  ? 472 GLN A CA  1 
ATOM   3350 C C   . GLN A 1 472 ? -21.497 -37.212 -6.738  1.00 37.77  ? 472 GLN A C   1 
ATOM   3351 O O   . GLN A 1 472 ? -22.101 -36.320 -6.142  1.00 39.86  ? 472 GLN A O   1 
ATOM   3352 C CB  . GLN A 1 472 ? -19.066 -37.203 -6.109  1.00 46.59  ? 472 GLN A CB  1 
ATOM   3353 C CG  . GLN A 1 472 ? -19.267 -36.414 -4.844  1.00 39.99  ? 472 GLN A CG  1 
ATOM   3354 C CD  . GLN A 1 472 ? -18.010 -36.409 -3.998  1.00 52.29  ? 472 GLN A CD  1 
ATOM   3355 O OE1 . GLN A 1 472 ? -18.005 -36.915 -2.879  1.00 58.71  ? 472 GLN A OE1 1 
ATOM   3356 N NE2 . GLN A 1 472 ? -16.923 -35.868 -4.543  1.00 58.81  ? 472 GLN A NE2 1 
ATOM   3357 N N   . LEU A 1 473 ? -22.016 -38.417 -6.970  1.00 36.55  ? 473 LEU A N   1 
ATOM   3358 C CA  . LEU A 1 473 ? -23.412 -38.716 -6.666  1.00 38.29  ? 473 LEU A CA  1 
ATOM   3359 C C   . LEU A 1 473 ? -23.661 -38.706 -5.159  1.00 40.28  ? 473 LEU A C   1 
ATOM   3360 O O   . LEU A 1 473 ? -22.873 -39.239 -4.372  1.00 40.44  ? 473 LEU A O   1 
ATOM   3361 C CB  . LEU A 1 473 ? -23.790 -40.073 -7.251  1.00 37.98  ? 473 LEU A CB  1 
ATOM   3362 C CG  . LEU A 1 473 ? -25.240 -40.399 -7.631  1.00 39.48  ? 473 LEU A CG  1 
ATOM   3363 C CD1 . LEU A 1 473 ? -25.303 -41.774 -8.271  1.00 45.82  ? 473 LEU A CD1 1 
ATOM   3364 C CD2 . LEU A 1 473 ? -26.184 -40.354 -6.482  1.00 41.03  ? 473 LEU A CD2 1 
ATOM   3365 N N   . ASN A 1 474 ? -24.781 -38.111 -4.757  1.00 39.51  ? 474 ASN A N   1 
ATOM   3366 C CA  . ASN A 1 474 ? -25.088 -37.888 -3.350  1.00 41.39  ? 474 ASN A CA  1 
ATOM   3367 C C   . ASN A 1 474 ? -26.288 -38.670 -2.845  1.00 43.21  ? 474 ASN A C   1 
ATOM   3368 O O   . ASN A 1 474 ? -26.347 -38.998 -1.656  1.00 49.38  ? 474 ASN A O   1 
ATOM   3369 C CB  . ASN A 1 474 ? -25.354 -36.394 -3.113  1.00 40.49  ? 474 ASN A CB  1 
ATOM   3370 C CG  . ASN A 1 474 ? -25.494 -36.037 -1.642  1.00 42.66  ? 474 ASN A CG  1 
ATOM   3371 O OD1 . ASN A 1 474 ? -24.811 -36.590 -0.787  1.00 46.68  ? 474 ASN A OD1 1 
ATOM   3372 N ND2 . ASN A 1 474 ? -26.413 -35.128 -1.342  1.00 48.49  ? 474 ASN A ND2 1 
ATOM   3373 N N   . TYR A 1 475 ? -27.240 -38.976 -3.714  1.00 38.51  ? 475 TYR A N   1 
ATOM   3374 C CA  . TYR A 1 475 ? -28.563 -39.397 -3.290  1.00 42.51  ? 475 TYR A CA  1 
ATOM   3375 C C   . TYR A 1 475 ? -29.347 -39.865 -4.514  1.00 46.20  ? 475 TYR A C   1 
ATOM   3376 O O   . TYR A 1 475 ? -29.211 -39.299 -5.606  1.00 44.88  ? 475 TYR A O   1 
ATOM   3377 C CB  . TYR A 1 475 ? -29.278 -38.242 -2.582  1.00 40.98  ? 475 TYR A CB  1 
ATOM   3378 C CG  . TYR A 1 475 ? -30.264 -38.648 -1.519  1.00 45.69  ? 475 TYR A CG  1 
ATOM   3379 C CD1 . TYR A 1 475 ? -29.851 -38.935 -0.226  1.00 41.18  ? 475 TYR A CD1 1 
ATOM   3380 C CD2 . TYR A 1 475 ? -31.626 -38.708 -1.806  1.00 45.71  ? 475 TYR A CD2 1 
ATOM   3381 C CE1 . TYR A 1 475 ? -30.775 -39.275 0.748   1.00 42.69  ? 475 TYR A CE1 1 
ATOM   3382 C CE2 . TYR A 1 475 ? -32.548 -39.058 -0.846  1.00 44.45  ? 475 TYR A CE2 1 
ATOM   3383 C CZ  . TYR A 1 475 ? -32.126 -39.343 0.429   1.00 43.86  ? 475 TYR A CZ  1 
ATOM   3384 O OH  . TYR A 1 475 ? -33.062 -39.700 1.380   1.00 43.45  ? 475 TYR A OH  1 
ATOM   3385 N N   . VAL A 1 476 ? -30.166 -40.901 -4.323  1.00 47.46  ? 476 VAL A N   1 
ATOM   3386 C CA  . VAL A 1 476 ? -30.921 -41.540 -5.402  1.00 44.57  ? 476 VAL A CA  1 
ATOM   3387 C C   . VAL A 1 476 ? -32.362 -41.709 -4.931  1.00 49.99  ? 476 VAL A C   1 
ATOM   3388 O O   . VAL A 1 476 ? -32.626 -42.492 -4.014  1.00 50.81  ? 476 VAL A O   1 
ATOM   3389 C CB  . VAL A 1 476 ? -30.333 -42.900 -5.793  1.00 39.85  ? 476 VAL A CB  1 
ATOM   3390 C CG1 . VAL A 1 476 ? -31.220 -43.548 -6.796  1.00 45.12  ? 476 VAL A CG1 1 
ATOM   3391 C CG2 . VAL A 1 476 ? -28.937 -42.759 -6.350  1.00 40.12  ? 476 VAL A CG2 1 
ATOM   3392 N N   . MET A 1 477 ? -33.302 -41.019 -5.567  1.00 42.94  ? 477 MET A N   1 
ATOM   3393 C CA  . MET A 1 477 ? -34.694 -41.244 -5.229  1.00 43.12  ? 477 MET A CA  1 
ATOM   3394 C C   . MET A 1 477 ? -35.415 -41.985 -6.348  1.00 48.62  ? 477 MET A C   1 
ATOM   3395 O O   . MET A 1 477 ? -34.997 -41.961 -7.509  1.00 46.52  ? 477 MET A O   1 
ATOM   3396 C CB  . MET A 1 477 ? -35.420 -39.941 -4.928  1.00 48.84  ? 477 MET A CB  1 
ATOM   3397 C CG  . MET A 1 477 ? -36.456 -40.115 -3.840  1.00 54.31  ? 477 MET A CG  1 
ATOM   3398 S SD  . MET A 1 477 ? -37.004 -38.589 -3.076  1.00 52.21  ? 477 MET A SD  1 
ATOM   3399 C CE  . MET A 1 477 ? -35.442 -37.950 -2.472  1.00 51.94  ? 477 MET A CE  1 
ATOM   3400 N N   . CYS A 1 478 ? -36.502 -42.656 -5.977  1.00 52.78  ? 478 CYS A N   1 
ATOM   3401 C CA  . CYS A 1 478 ? -37.348 -43.381 -6.914  1.00 51.29  ? 478 CYS A CA  1 
ATOM   3402 C C   . CYS A 1 478 ? -38.778 -42.869 -6.804  1.00 54.31  ? 478 CYS A C   1 
ATOM   3403 O O   . CYS A 1 478 ? -39.406 -42.946 -5.735  1.00 54.11  ? 478 CYS A O   1 
ATOM   3404 C CB  . CYS A 1 478 ? -37.281 -44.876 -6.650  1.00 44.42  ? 478 CYS A CB  1 
ATOM   3405 S SG  . CYS A 1 478 ? -35.812 -45.531 -7.337  1.00 41.77  ? 478 CYS A SG  1 
ATOM   3406 N N   . PHE A 1 479 ? -39.286 -42.342 -7.901  1.00 46.37  ? 479 PHE A N   1 
ATOM   3407 C CA  . PHE A 1 479 ? -40.640 -41.836 -7.928  1.00 51.40  ? 479 PHE A CA  1 
ATOM   3408 C C   . PHE A 1 479 ? -41.508 -42.792 -8.723  1.00 54.54  ? 479 PHE A C   1 
ATOM   3409 O O   . PHE A 1 479 ? -41.065 -43.357 -9.728  1.00 54.35  ? 479 PHE A O   1 
ATOM   3410 C CB  . PHE A 1 479 ? -40.680 -40.412 -8.489  1.00 48.86  ? 479 PHE A CB  1 
ATOM   3411 C CG  . PHE A 1 479 ? -40.019 -39.418 -7.589  1.00 53.56  ? 479 PHE A CG  1 
ATOM   3412 C CD1 . PHE A 1 479 ? -38.638 -39.238 -7.618  1.00 53.76  ? 479 PHE A CD1 1 
ATOM   3413 C CD2 . PHE A 1 479 ? -40.770 -38.692 -6.670  1.00 55.29  ? 479 PHE A CD2 1 
ATOM   3414 C CE1 . PHE A 1 479 ? -38.020 -38.331 -6.755  1.00 54.52  ? 479 PHE A CE1 1 
ATOM   3415 C CE2 . PHE A 1 479 ? -40.164 -37.777 -5.797  1.00 49.56  ? 479 PHE A CE2 1 
ATOM   3416 C CZ  . PHE A 1 479 ? -38.786 -37.598 -5.842  1.00 51.81  ? 479 PHE A CZ  1 
ATOM   3417 N N   . LEU A 1 480 ? -42.722 -43.007 -8.219  1.00 52.22  ? 480 LEU A N   1 
ATOM   3418 C CA  . LEU A 1 480 ? -43.704 -43.865 -8.848  1.00 46.11  ? 480 LEU A CA  1 
ATOM   3419 C C   . LEU A 1 480 ? -44.500 -43.070 -9.868  1.00 47.60  ? 480 LEU A C   1 
ATOM   3420 O O   . LEU A 1 480 ? -44.883 -41.923 -9.621  1.00 47.64  ? 480 LEU A O   1 
ATOM   3421 C CB  . LEU A 1 480 ? -44.631 -44.467 -7.794  1.00 43.47  ? 480 LEU A CB  1 
ATOM   3422 C CG  . LEU A 1 480 ? -43.853 -45.440 -6.907  1.00 48.08  ? 480 LEU A CG  1 
ATOM   3423 C CD1 . LEU A 1 480 ? -44.570 -45.785 -5.603  1.00 45.20  ? 480 LEU A CD1 1 
ATOM   3424 C CD2 . LEU A 1 480 ? -43.475 -46.692 -7.697  1.00 50.56  ? 480 LEU A CD2 1 
ATOM   3425 N N   . MET A 1 481 ? -44.723 -43.676 -11.029 1.00 53.17  ? 481 MET A N   1 
ATOM   3426 C CA  . MET A 1 481 ? -45.502 -43.037 -12.077 1.00 54.84  ? 481 MET A CA  1 
ATOM   3427 C C   . MET A 1 481 ? -46.972 -43.019 -11.683 1.00 56.29  ? 481 MET A C   1 
ATOM   3428 O O   . MET A 1 481 ? -47.386 -43.698 -10.740 1.00 62.09  ? 481 MET A O   1 
ATOM   3429 C CB  . MET A 1 481 ? -45.321 -43.781 -13.391 1.00 55.60  ? 481 MET A CB  1 
ATOM   3430 C CG  . MET A 1 481 ? -43.912 -43.749 -13.937 1.00 59.20  ? 481 MET A CG  1 
ATOM   3431 S SD  . MET A 1 481 ? -43.852 -43.944 -15.733 1.00 54.90  ? 481 MET A SD  1 
ATOM   3432 C CE  . MET A 1 481 ? -42.221 -44.678 -15.915 1.00 52.95  ? 481 MET A CE  1 
ATOM   3433 N N   . GLN A 1 482 ? -47.770 -42.247 -12.415 1.00 47.24  ? 482 GLN A N   1 
ATOM   3434 C CA  . GLN A 1 482 ? -49.212 -42.247 -12.185 1.00 59.14  ? 482 GLN A CA  1 
ATOM   3435 C C   . GLN A 1 482 ? -49.853 -43.514 -12.759 1.00 68.94  ? 482 GLN A C   1 
ATOM   3436 O O   . GLN A 1 482 ? -49.766 -43.776 -13.964 1.00 68.55  ? 482 GLN A O   1 
ATOM   3437 C CB  . GLN A 1 482 ? -49.848 -40.994 -12.773 1.00 59.57  ? 482 GLN A CB  1 
ATOM   3438 C CG  . GLN A 1 482 ? -49.762 -39.796 -11.859 1.00 62.98  ? 482 GLN A CG  1 
ATOM   3439 C CD  . GLN A 1 482 ? -50.530 -38.619 -12.389 1.00 65.05  ? 482 GLN A CD  1 
ATOM   3440 O OE1 . GLN A 1 482 ? -50.423 -38.289 -13.565 1.00 68.04  ? 482 GLN A OE1 1 
ATOM   3441 N NE2 . GLN A 1 482 ? -51.337 -37.990 -11.531 1.00 65.27  ? 482 GLN A NE2 1 
ATOM   3442 N N   . GLY A 1 483 ? -50.499 -44.302 -11.895 1.00 73.32  ? 483 GLY A N   1 
ATOM   3443 C CA  . GLY A 1 483 ? -51.012 -45.612 -12.276 1.00 79.83  ? 483 GLY A CA  1 
ATOM   3444 C C   . GLY A 1 483 ? -49.927 -46.657 -12.490 1.00 79.23  ? 483 GLY A C   1 
ATOM   3445 O O   . GLY A 1 483 ? -49.750 -47.135 -13.624 1.00 70.16  ? 483 GLY A O   1 
ATOM   3446 N N   . SER A 1 484 ? -49.255 -47.053 -11.385 1.00 80.77  ? 484 SER A N   1 
ATOM   3447 C CA  . SER A 1 484 ? -47.904 -47.636 -11.338 1.00 79.12  ? 484 SER A CA  1 
ATOM   3448 C C   . SER A 1 484 ? -47.476 -48.233 -12.683 1.00 73.27  ? 484 SER A C   1 
ATOM   3449 O O   . SER A 1 484 ? -47.456 -49.451 -12.896 1.00 71.14  ? 484 SER A O   1 
ATOM   3450 C CB  . SER A 1 484 ? -47.789 -48.657 -10.192 1.00 79.37  ? 484 SER A CB  1 
ATOM   3451 O OG  . SER A 1 484 ? -47.701 -48.019 -8.912  1.00 62.93  ? 484 SER A OG  1 
ATOM   3452 N N   . ARG A 1 485 ? -47.155 -47.328 -13.600 1.00 72.34  ? 485 ARG A N   1 
ATOM   3453 C CA  . ARG A 1 485 ? -46.764 -47.608 -14.967 1.00 70.09  ? 485 ARG A CA  1 
ATOM   3454 C C   . ARG A 1 485 ? -45.248 -47.570 -15.109 1.00 64.49  ? 485 ARG A C   1 
ATOM   3455 O O   . ARG A 1 485 ? -44.723 -47.675 -16.223 1.00 58.33  ? 485 ARG A O   1 
ATOM   3456 C CB  . ARG A 1 485 ? -47.452 -46.582 -15.874 1.00 67.41  ? 485 ARG A CB  1 
ATOM   3457 C CG  . ARG A 1 485 ? -47.907 -47.064 -17.236 1.00 69.88  ? 485 ARG A CG  1 
ATOM   3458 C CD  . ARG A 1 485 ? -48.594 -45.896 -17.907 1.00 64.83  ? 485 ARG A CD  1 
ATOM   3459 N NE  . ARG A 1 485 ? -49.692 -46.248 -18.814 1.00 64.56  ? 485 ARG A NE  1 
ATOM   3460 C CZ  . ARG A 1 485 ? -50.914 -46.601 -18.412 1.00 63.08  ? 485 ARG A CZ  1 
ATOM   3461 N NH1 . ARG A 1 485 ? -51.191 -46.740 -17.121 1.00 72.29  ? 485 ARG A NH1 1 
ATOM   3462 N NH2 . ARG A 1 485 ? -51.863 -46.841 -19.297 1.00 62.93  ? 485 ARG A NH2 1 
ATOM   3463 N N   . GLY A 1 486 ? -44.550 -47.417 -13.993 1.00 66.20  ? 486 GLY A N   1 
ATOM   3464 C CA  . GLY A 1 486 ? -43.101 -47.450 -13.944 1.00 61.78  ? 486 GLY A CA  1 
ATOM   3465 C C   . GLY A 1 486 ? -42.601 -46.719 -12.712 1.00 58.50  ? 486 GLY A C   1 
ATOM   3466 O O   . GLY A 1 486 ? -43.370 -46.192 -11.913 1.00 56.40  ? 486 GLY A O   1 
ATOM   3467 N N   . THR A 1 487 ? -41.275 -46.711 -12.573 1.00 65.76  ? 487 THR A N   1 
ATOM   3468 C CA  . THR A 1 487 ? -40.572 -45.904 -11.579 1.00 58.25  ? 487 THR A CA  1 
ATOM   3469 C C   . THR A 1 487 ? -39.543 -45.022 -12.276 1.00 51.75  ? 487 THR A C   1 
ATOM   3470 O O   . THR A 1 487 ? -38.725 -45.508 -13.073 1.00 51.02  ? 487 THR A O   1 
ATOM   3471 C CB  . THR A 1 487 ? -39.893 -46.781 -10.512 1.00 56.43  ? 487 THR A CB  1 
ATOM   3472 O OG1 . THR A 1 487 ? -40.882 -47.362 -9.638  1.00 54.46  ? 487 THR A OG1 1 
ATOM   3473 C CG2 . THR A 1 487 ? -38.879 -45.968 -9.719  1.00 50.48  ? 487 THR A CG2 1 
ATOM   3474 N N   . ILE A 1 488 ? -39.591 -43.729 -11.990 1.00 53.78  ? 488 ILE A N   1 
ATOM   3475 C CA  . ILE A 1 488 ? -38.620 -42.776 -12.518 1.00 52.18  ? 488 ILE A CA  1 
ATOM   3476 C C   . ILE A 1 488 ? -37.660 -42.435 -11.389 1.00 50.26  ? 488 ILE A C   1 
ATOM   3477 O O   . ILE A 1 488 ? -38.105 -41.894 -10.364 1.00 52.19  ? 488 ILE A O   1 
ATOM   3478 C CB  . ILE A 1 488 ? -39.282 -41.506 -13.061 1.00 44.87  ? 488 ILE A CB  1 
ATOM   3479 C CG1 . ILE A 1 488 ? -40.576 -41.847 -13.792 1.00 50.61  ? 488 ILE A CG1 1 
ATOM   3480 C CG2 . ILE A 1 488 ? -38.373 -40.899 -14.060 1.00 43.03  ? 488 ILE A CG2 1 
ATOM   3481 C CD1 . ILE A 1 488 ? -41.529 -40.688 -13.903 1.00 43.80  ? 488 ILE A CD1 1 
ATOM   3482 N N   . PRO A 1 489 ? -36.369 -42.749 -11.515 1.00 48.50  ? 489 PRO A N   1 
ATOM   3483 C CA  . PRO A 1 489 ? -35.406 -42.390 -10.480 1.00 43.17  ? 489 PRO A CA  1 
ATOM   3484 C C   . PRO A 1 489 ? -34.736 -41.061 -10.770 1.00 39.33  ? 489 PRO A C   1 
ATOM   3485 O O   . PRO A 1 489 ? -34.590 -40.622 -11.913 1.00 37.74  ? 489 PRO A O   1 
ATOM   3486 C CB  . PRO A 1 489 ? -34.398 -43.548 -10.526 1.00 46.72  ? 489 PRO A CB  1 
ATOM   3487 C CG  . PRO A 1 489 ? -34.587 -44.206 -11.868 1.00 44.66  ? 489 PRO A CG  1 
ATOM   3488 C CD  . PRO A 1 489 ? -35.732 -43.524 -12.588 1.00 47.16  ? 489 PRO A CD  1 
ATOM   3489 N N   . VAL A 1 490 ? -34.331 -40.419 -9.686  1.00 42.50  ? 490 VAL A N   1 
ATOM   3490 C CA  . VAL A 1 490 ? -33.822 -39.059 -9.717  1.00 44.88  ? 490 VAL A CA  1 
ATOM   3491 C C   . VAL A 1 490 ? -32.537 -39.015 -8.901  1.00 40.62  ? 490 VAL A C   1 
ATOM   3492 O O   . VAL A 1 490 ? -32.507 -39.479 -7.755  1.00 38.85  ? 490 VAL A O   1 
ATOM   3493 C CB  . VAL A 1 490 ? -34.868 -38.066 -9.185  1.00 36.56  ? 490 VAL A CB  1 
ATOM   3494 C CG1 . VAL A 1 490 ? -34.229 -36.757 -8.917  1.00 33.41  ? 490 VAL A CG1 1 
ATOM   3495 C CG2 . VAL A 1 490 ? -35.952 -37.889 -10.207 1.00 36.91  ? 490 VAL A CG2 1 
ATOM   3496 N N   . LEU A 1 491 ? -31.476 -38.477 -9.503  1.00 39.34  ? 491 LEU A N   1 
ATOM   3497 C CA  . LEU A 1 491 ? -30.140 -38.500 -8.925  1.00 42.15  ? 491 LEU A CA  1 
ATOM   3498 C C   . LEU A 1 491 ? -29.710 -37.098 -8.490  1.00 44.84  ? 491 LEU A C   1 
ATOM   3499 O O   . LEU A 1 491 ? -29.851 -36.125 -9.248  1.00 40.78  ? 491 LEU A O   1 
ATOM   3500 C CB  . LEU A 1 491 ? -29.125 -39.093 -9.908  1.00 39.24  ? 491 LEU A CB  1 
ATOM   3501 C CG  . LEU A 1 491 ? -29.524 -40.435 -10.541 1.00 39.76  ? 491 LEU A CG  1 
ATOM   3502 C CD1 . LEU A 1 491 ? -28.418 -41.061 -11.377 1.00 31.38  ? 491 LEU A CD1 1 
ATOM   3503 C CD2 . LEU A 1 491 ? -30.027 -41.407 -9.496  1.00 41.26  ? 491 LEU A CD2 1 
ATOM   3504 N N   . THR A 1 492 ? -29.173 -37.019 -7.268  1.00 39.94  ? 492 THR A N   1 
ATOM   3505 C CA  . THR A 1 492 ? -28.675 -35.801 -6.646  1.00 40.25  ? 492 THR A CA  1 
ATOM   3506 C C   . THR A 1 492 ? -27.149 -35.824 -6.545  1.00 44.91  ? 492 THR A C   1 
ATOM   3507 O O   . THR A 1 492 ? -26.553 -36.836 -6.160  1.00 45.52  ? 492 THR A O   1 
ATOM   3508 C CB  . THR A 1 492 ? -29.287 -35.664 -5.267  1.00 38.58  ? 492 THR A CB  1 
ATOM   3509 O OG1 . THR A 1 492 ? -30.687 -35.937 -5.367  1.00 40.21  ? 492 THR A OG1 1 
ATOM   3510 C CG2 . THR A 1 492 ? -29.036 -34.294 -4.683  1.00 39.10  ? 492 THR A CG2 1 
ATOM   3511 N N   . TRP A 1 493 ? -26.508 -34.709 -6.890  1.00 40.34  ? 493 TRP A N   1 
ATOM   3512 C CA  . TRP A 1 493 ? -25.055 -34.689 -6.929  1.00 39.85  ? 493 TRP A CA  1 
ATOM   3513 C C   . TRP A 1 493 ? -24.523 -33.439 -6.239  1.00 35.07  ? 493 TRP A C   1 
ATOM   3514 O O   . TRP A 1 493 ? -25.171 -32.396 -6.208  1.00 34.56  ? 493 TRP A O   1 
ATOM   3515 C CB  . TRP A 1 493 ? -24.502 -34.730 -8.360  1.00 40.25  ? 493 TRP A CB  1 
ATOM   3516 C CG  . TRP A 1 493 ? -25.143 -35.692 -9.310  1.00 38.87  ? 493 TRP A CG  1 
ATOM   3517 C CD1 . TRP A 1 493 ? -26.413 -35.641 -9.785  1.00 41.25  ? 493 TRP A CD1 1 
ATOM   3518 C CD2 . TRP A 1 493 ? -24.515 -36.811 -9.961  1.00 39.05  ? 493 TRP A CD2 1 
ATOM   3519 N NE1 . TRP A 1 493 ? -26.626 -36.669 -10.668 1.00 46.67  ? 493 TRP A NE1 1 
ATOM   3520 C CE2 . TRP A 1 493 ? -25.471 -37.395 -10.797 1.00 39.79  ? 493 TRP A CE2 1 
ATOM   3521 C CE3 . TRP A 1 493 ? -23.236 -37.376 -9.909  1.00 43.54  ? 493 TRP A CE3 1 
ATOM   3522 C CZ2 . TRP A 1 493 ? -25.191 -38.510 -11.586 1.00 39.95  ? 493 TRP A CZ2 1 
ATOM   3523 C CZ3 . TRP A 1 493 ? -22.965 -38.494 -10.683 1.00 41.32  ? 493 TRP A CZ3 1 
ATOM   3524 C CH2 . TRP A 1 493 ? -23.937 -39.045 -11.510 1.00 42.61  ? 493 TRP A CH2 1 
ATOM   3525 N N   . THR A 1 494 ? -23.323 -33.543 -5.709  1.00 34.34  ? 494 THR A N   1 
ATOM   3526 C CA  . THR A 1 494 ? -22.694 -32.401 -5.089  1.00 38.90  ? 494 THR A CA  1 
ATOM   3527 C C   . THR A 1 494 ? -21.458 -32.034 -5.903  1.00 39.47  ? 494 THR A C   1 
ATOM   3528 O O   . THR A 1 494 ? -21.108 -32.703 -6.879  1.00 37.92  ? 494 THR A O   1 
ATOM   3529 C CB  . THR A 1 494 ? -22.358 -32.696 -3.620  1.00 34.23  ? 494 THR A CB  1 
ATOM   3530 O OG1 . THR A 1 494 ? -21.269 -33.628 -3.557  1.00 34.47  ? 494 THR A OG1 1 
ATOM   3531 C CG2 . THR A 1 494 ? -23.578 -33.243 -2.888  1.00 23.73  ? 494 THR A CG2 1 
ATOM   3532 N N   . HIS A 1 495 ? -20.794 -30.955 -5.503  1.00 38.28  ? 495 HIS A N   1 
ATOM   3533 C CA  . HIS A 1 495 ? -19.598 -30.534 -6.206  1.00 39.64  ? 495 HIS A CA  1 
ATOM   3534 C C   . HIS A 1 495 ? -18.356 -31.258 -5.711  1.00 42.08  ? 495 HIS A C   1 
ATOM   3535 O O   . HIS A 1 495 ? -18.184 -31.486 -4.505  1.00 35.62  ? 495 HIS A O   1 
ATOM   3536 C CB  . HIS A 1 495 ? -19.360 -29.038 -6.074  1.00 38.71  ? 495 HIS A CB  1 
ATOM   3537 C CG  . HIS A 1 495 ? -18.583 -28.464 -7.215  1.00 36.12  ? 495 HIS A CG  1 
ATOM   3538 N ND1 . HIS A 1 495 ? -17.281 -28.034 -7.083  1.00 35.56  ? 495 HIS A ND1 1 
ATOM   3539 C CD2 . HIS A 1 495 ? -18.930 -28.228 -8.501  1.00 35.03  ? 495 HIS A CD2 1 
ATOM   3540 C CE1 . HIS A 1 495 ? -16.858 -27.560 -8.242  1.00 39.20  ? 495 HIS A CE1 1 
ATOM   3541 N NE2 . HIS A 1 495 ? -17.838 -27.670 -9.121  1.00 35.83  ? 495 HIS A NE2 1 
ATOM   3542 N N   . LYS A 1 496 ? -17.484 -31.586 -6.676  1.00 44.29  ? 496 LYS A N   1 
ATOM   3543 C CA  . LYS A 1 496 ? -16.160 -32.139 -6.423  1.00 42.64  ? 496 LYS A CA  1 
ATOM   3544 C C   . LYS A 1 496 ? -15.340 -31.277 -5.479  1.00 43.93  ? 496 LYS A C   1 
ATOM   3545 O O   . LYS A 1 496 ? -14.422 -31.789 -4.826  1.00 48.46  ? 496 LYS A O   1 
ATOM   3546 C CB  . LYS A 1 496 ? -15.420 -32.287 -7.751  1.00 50.88  ? 496 LYS A CB  1 
ATOM   3547 C CG  . LYS A 1 496 ? -14.000 -32.828 -7.643  1.00 60.82  ? 496 LYS A CG  1 
ATOM   3548 C CD  . LYS A 1 496 ? -13.156 -32.297 -8.781  1.00 69.08  ? 496 LYS A CD  1 
ATOM   3549 C CE  . LYS A 1 496 ? -12.031 -33.242 -9.168  1.00 72.84  ? 496 LYS A CE  1 
ATOM   3550 N NZ  . LYS A 1 496 ? -11.373 -32.736 -10.415 1.00 71.99  ? 496 LYS A NZ  1 
ATOM   3551 N N   . SER A 1 497 ? -15.641 -29.983 -5.386  1.00 40.65  ? 497 SER A N   1 
ATOM   3552 C CA  . SER A 1 497 ? -14.784 -29.132 -4.581  1.00 35.54  ? 497 SER A CA  1 
ATOM   3553 C C   . SER A 1 497 ? -14.952 -29.389 -3.108  1.00 36.04  ? 497 SER A C   1 
ATOM   3554 O O   . SER A 1 497 ? -14.131 -28.907 -2.327  1.00 41.93  ? 497 SER A O   1 
ATOM   3555 C CB  . SER A 1 497 ? -15.064 -27.660 -4.852  1.00 42.52  ? 497 SER A CB  1 
ATOM   3556 O OG  . SER A 1 497 ? -16.428 -27.357 -4.641  1.00 43.37  ? 497 SER A OG  1 
ATOM   3557 N N   . VAL A 1 498 ? -15.998 -30.116 -2.712  1.00 40.07  ? 498 VAL A N   1 
ATOM   3558 C CA  . VAL A 1 498 ? -16.219 -30.372 -1.297  1.00 38.34  ? 498 VAL A CA  1 
ATOM   3559 C C   . VAL A 1 498 ? -15.067 -31.210 -0.765  1.00 39.98  ? 498 VAL A C   1 
ATOM   3560 O O   . VAL A 1 498 ? -14.542 -32.091 -1.454  1.00 43.34  ? 498 VAL A O   1 
ATOM   3561 C CB  . VAL A 1 498 ? -17.570 -31.073 -1.083  1.00 37.67  ? 498 VAL A CB  1 
ATOM   3562 C CG1 . VAL A 1 498 ? -17.848 -31.246 0.396   1.00 41.59  ? 498 VAL A CG1 1 
ATOM   3563 C CG2 . VAL A 1 498 ? -18.696 -30.305 -1.756  1.00 39.15  ? 498 VAL A CG2 1 
ATOM   3564 N N   . ASP A 1 499 ? -14.640 -30.912 0.455   1.00 45.94  ? 499 ASP A N   1 
ATOM   3565 C CA  . ASP A 1 499 ? -13.584 -31.657 1.130   1.00 48.17  ? 499 ASP A CA  1 
ATOM   3566 C C   . ASP A 1 499 ? -14.224 -32.489 2.227   1.00 42.86  ? 499 ASP A C   1 
ATOM   3567 O O   . ASP A 1 499 ? -14.885 -31.926 3.102   1.00 43.12  ? 499 ASP A O   1 
ATOM   3568 C CB  . ASP A 1 499 ? -12.546 -30.703 1.720   1.00 46.80  ? 499 ASP A CB  1 
ATOM   3569 C CG  . ASP A 1 499 ? -11.485 -31.420 2.528   1.00 53.10  ? 499 ASP A CG  1 
ATOM   3570 O OD1 . ASP A 1 499 ? -11.393 -32.668 2.424   1.00 56.07  ? 499 ASP A OD1 1 
ATOM   3571 O OD2 . ASP A 1 499 ? -10.731 -30.734 3.254   1.00 54.29  ? 499 ASP A OD2 1 
ATOM   3572 N N   . PHE A 1 500 ? -14.030 -33.816 2.186   1.00 43.77  ? 500 PHE A N   1 
ATOM   3573 C CA  . PHE A 1 500 ? -14.609 -34.668 3.233   1.00 46.29  ? 500 PHE A CA  1 
ATOM   3574 C C   . PHE A 1 500 ? -14.109 -34.269 4.614   1.00 47.32  ? 500 PHE A C   1 
ATOM   3575 O O   . PHE A 1 500 ? -14.896 -34.174 5.576   1.00 42.66  ? 500 PHE A O   1 
ATOM   3576 C CB  . PHE A 1 500 ? -14.280 -36.146 3.015   1.00 40.59  ? 500 PHE A CB  1 
ATOM   3577 C CG  . PHE A 1 500 ? -14.757 -37.023 4.141   1.00 42.35  ? 500 PHE A CG  1 
ATOM   3578 C CD1 . PHE A 1 500 ? -16.074 -37.440 4.209   1.00 45.04  ? 500 PHE A CD1 1 
ATOM   3579 C CD2 . PHE A 1 500 ? -13.909 -37.331 5.208   1.00 44.91  ? 500 PHE A CD2 1 
ATOM   3580 C CE1 . PHE A 1 500 ? -16.522 -38.227 5.268   1.00 42.98  ? 500 PHE A CE1 1 
ATOM   3581 C CE2 . PHE A 1 500 ? -14.357 -38.084 6.281   1.00 35.10  ? 500 PHE A CE2 1 
ATOM   3582 C CZ  . PHE A 1 500 ? -15.660 -38.540 6.302   1.00 38.26  ? 500 PHE A CZ  1 
ATOM   3583 N N   . PHE A 1 501 ? -12.793 -34.030 4.713   1.00 42.43  ? 501 PHE A N   1 
ATOM   3584 C CA  . PHE A 1 501 ? -12.034 -33.905 5.944   1.00 41.65  ? 501 PHE A CA  1 
ATOM   3585 C C   . PHE A 1 501 ? -12.149 -32.549 6.629   1.00 46.04  ? 501 PHE A C   1 
ATOM   3586 O O   . PHE A 1 501 ? -11.715 -32.450 7.777   1.00 52.30  ? 501 PHE A O   1 
ATOM   3587 C CB  . PHE A 1 501 ? -10.548 -34.135 5.661   1.00 49.20  ? 501 PHE A CB  1 
ATOM   3588 C CG  . PHE A 1 501 ? -10.210 -35.500 5.121   1.00 48.01  ? 501 PHE A CG  1 
ATOM   3589 C CD1 . PHE A 1 501 ? -10.155 -36.604 5.965   1.00 46.91  ? 501 PHE A CD1 1 
ATOM   3590 C CD2 . PHE A 1 501 ? -9.896  -35.669 3.783   1.00 43.49  ? 501 PHE A CD2 1 
ATOM   3591 C CE1 . PHE A 1 501 ? -9.830  -37.846 5.484   1.00 34.93  ? 501 PHE A CE1 1 
ATOM   3592 C CE2 . PHE A 1 501 ? -9.565  -36.909 3.294   1.00 44.10  ? 501 PHE A CE2 1 
ATOM   3593 C CZ  . PHE A 1 501 ? -9.533  -38.002 4.153   1.00 43.39  ? 501 PHE A CZ  1 
ATOM   3594 N N   . ASN A 1 502 ? -12.648 -31.498 5.965   1.00 44.45  ? 502 ASN A N   1 
ATOM   3595 C CA  . ASN A 1 502 ? -12.736 -30.153 6.562   1.00 46.58  ? 502 ASN A CA  1 
ATOM   3596 C C   . ASN A 1 502 ? -11.355 -29.636 6.972   1.00 50.05  ? 502 ASN A C   1 
ATOM   3597 O O   . ASN A 1 502 ? -11.109 -29.271 8.132   1.00 47.31  ? 502 ASN A O   1 
ATOM   3598 C CB  . ASN A 1 502 ? -13.675 -30.123 7.775   1.00 42.85  ? 502 ASN A CB  1 
ATOM   3599 C CG  . ASN A 1 502 ? -15.124 -30.126 7.402   1.00 39.29  ? 502 ASN A CG  1 
ATOM   3600 O OD1 . ASN A 1 502 ? -15.494 -29.720 6.310   1.00 43.52  ? 502 ASN A OD1 1 
ATOM   3601 N ND2 . ASN A 1 502 ? -15.969 -30.550 8.332   1.00 41.89  ? 502 ASN A ND2 1 
ATOM   3602 N N   . MET A 1 503 ? -10.450 -29.610 6.002   1.00 52.80  ? 503 MET A N   1 
ATOM   3603 C CA  . MET A 1 503 ? -9.064  -29.264 6.295   1.00 58.15  ? 503 MET A CA  1 
ATOM   3604 C C   . MET A 1 503 ? -8.880  -27.764 6.404   1.00 49.39  ? 503 MET A C   1 
ATOM   3605 O O   . MET A 1 503 ? -9.432  -27.001 5.610   1.00 47.77  ? 503 MET A O   1 
ATOM   3606 C CB  . MET A 1 503 ? -8.116  -29.779 5.218   1.00 63.14  ? 503 MET A CB  1 
ATOM   3607 C CG  . MET A 1 503 ? -6.671  -29.783 5.676   1.00 60.72  ? 503 MET A CG  1 
ATOM   3608 S SD  . MET A 1 503 ? -5.732  -30.765 4.517   1.00 108.72 ? 503 MET A SD  1 
ATOM   3609 C CE  . MET A 1 503 ? -6.550  -32.364 4.730   1.00 67.34  ? 503 MET A CE  1 
ATOM   3610 N N   . ILE A 1 504 ? -8.066  -27.353 7.367   1.00 47.15  ? 504 ILE A N   1 
ATOM   3611 C CA  . ILE A 1 504 ? -7.654  -25.968 7.513   1.00 40.29  ? 504 ILE A CA  1 
ATOM   3612 C C   . ILE A 1 504 ? -6.271  -25.827 6.910   1.00 43.24  ? 504 ILE A C   1 
ATOM   3613 O O   . ILE A 1 504 ? -5.292  -26.281 7.504   1.00 52.80  ? 504 ILE A O   1 
ATOM   3614 C CB  . ILE A 1 504 ? -7.641  -25.543 8.975   1.00 34.68  ? 504 ILE A CB  1 
ATOM   3615 C CG1 . ILE A 1 504 ? -8.970  -25.864 9.622   1.00 32.53  ? 504 ILE A CG1 1 
ATOM   3616 C CG2 . ILE A 1 504 ? -7.307  -24.089 9.041   1.00 41.21  ? 504 ILE A CG2 1 
ATOM   3617 C CD1 . ILE A 1 504 ? -10.120 -25.465 8.807   1.00 41.02  ? 504 ILE A CD1 1 
ATOM   3618 N N   . ASP A 1 505 ? -6.179  -25.191 5.747   1.00 39.08  ? 505 ASP A N   1 
ATOM   3619 C CA  . ASP A 1 505 ? -4.903  -25.010 5.072   1.00 37.82  ? 505 ASP A CA  1 
ATOM   3620 C C   . ASP A 1 505 ? -3.960  -24.197 5.954   1.00 46.66  ? 505 ASP A C   1 
ATOM   3621 O O   . ASP A 1 505 ? -4.386  -23.464 6.851   1.00 51.10  ? 505 ASP A O   1 
ATOM   3622 C CB  . ASP A 1 505 ? -5.119  -24.314 3.729   1.00 41.30  ? 505 ASP A CB  1 
ATOM   3623 C CG  . ASP A 1 505 ? -3.996  -24.558 2.743   1.00 48.57  ? 505 ASP A CG  1 
ATOM   3624 O OD1 . ASP A 1 505 ? -2.892  -24.010 2.931   1.00 52.96  ? 505 ASP A OD1 1 
ATOM   3625 O OD2 . ASP A 1 505 ? -4.222  -25.300 1.763   1.00 51.50  ? 505 ASP A OD2 1 
ATOM   3626 N N   . SER A 1 506 ? -2.654  -24.345 5.705   1.00 50.27  ? 506 SER A N   1 
ATOM   3627 C CA  . SER A 1 506 ? -1.648  -23.628 6.484   1.00 48.76  ? 506 SER A CA  1 
ATOM   3628 C C   . SER A 1 506 ? -1.094  -22.396 5.782   1.00 45.88  ? 506 SER A C   1 
ATOM   3629 O O   . SER A 1 506 ? -0.610  -21.493 6.466   1.00 46.72  ? 506 SER A O   1 
ATOM   3630 C CB  . SER A 1 506 ? -0.482  -24.557 6.875   1.00 56.90  ? 506 SER A CB  1 
ATOM   3631 O OG  . SER A 1 506 ? 0.068   -25.284 5.780   1.00 60.97  ? 506 SER A OG  1 
ATOM   3632 N N   . LYS A 1 507 ? -1.163  -22.333 4.449   1.00 44.45  ? 507 LYS A N   1 
ATOM   3633 C CA  . LYS A 1 507 ? -0.765  -21.153 3.688   1.00 43.16  ? 507 LYS A CA  1 
ATOM   3634 C C   . LYS A 1 507 ? -1.943  -20.318 3.183   1.00 48.37  ? 507 LYS A C   1 
ATOM   3635 O O   . LYS A 1 507 ? -1.783  -19.109 2.980   1.00 49.47  ? 507 LYS A O   1 
ATOM   3636 C CB  . LYS A 1 507 ? 0.098   -21.557 2.485   1.00 44.48  ? 507 LYS A CB  1 
ATOM   3637 C CG  . LYS A 1 507 ? 1.594   -21.824 2.765   1.00 54.04  ? 507 LYS A CG  1 
ATOM   3638 C CD  . LYS A 1 507 ? 1.845   -23.045 3.658   1.00 59.02  ? 507 LYS A CD  1 
ATOM   3639 C CE  . LYS A 1 507 ? 3.330   -23.414 3.743   1.00 64.47  ? 507 LYS A CE  1 
ATOM   3640 N NZ  . LYS A 1 507 ? 3.805   -24.259 2.618   1.00 65.11  ? 507 LYS A NZ  1 
ATOM   3641 N N   . LYS A 1 508 ? -3.115  -20.927 2.976   1.00 46.10  ? 508 LYS A N   1 
ATOM   3642 C CA  . LYS A 1 508 ? -4.254  -20.294 2.322   1.00 36.45  ? 508 LYS A CA  1 
ATOM   3643 C C   . LYS A 1 508 ? -5.304  -19.837 3.329   1.00 37.71  ? 508 LYS A C   1 
ATOM   3644 O O   . LYS A 1 508 ? -5.269  -20.183 4.506   1.00 42.04  ? 508 LYS A O   1 
ATOM   3645 C CB  . LYS A 1 508 ? -4.921  -21.254 1.335   1.00 43.64  ? 508 LYS A CB  1 
ATOM   3646 C CG  . LYS A 1 508 ? -4.182  -21.543 0.039   1.00 50.69  ? 508 LYS A CG  1 
ATOM   3647 C CD  . LYS A 1 508 ? -5.010  -22.532 -0.808  1.00 44.71  ? 508 LYS A CD  1 
ATOM   3648 C CE  . LYS A 1 508 ? -4.356  -22.835 -2.136  1.00 48.41  ? 508 LYS A CE  1 
ATOM   3649 N NZ  . LYS A 1 508 ? -5.366  -23.429 -3.051  1.00 61.59  ? 508 LYS A NZ  1 
ATOM   3650 N N   . ILE A 1 509 ? -6.270  -19.064 2.836   1.00 35.13  ? 509 ILE A N   1 
ATOM   3651 C CA  . ILE A 1 509 ? -7.435  -18.680 3.621   1.00 35.92  ? 509 ILE A CA  1 
ATOM   3652 C C   . ILE A 1 509 ? -8.513  -19.730 3.422   1.00 36.13  ? 509 ILE A C   1 
ATOM   3653 O O   . ILE A 1 509 ? -8.846  -20.072 2.283   1.00 38.46  ? 509 ILE A O   1 
ATOM   3654 C CB  . ILE A 1 509 ? -7.949  -17.286 3.221   1.00 35.22  ? 509 ILE A CB  1 
ATOM   3655 C CG1 . ILE A 1 509 ? -6.888  -16.210 3.457   1.00 33.94  ? 509 ILE A CG1 1 
ATOM   3656 C CG2 . ILE A 1 509 ? -9.270  -16.954 3.946   1.00 29.99  ? 509 ILE A CG2 1 
ATOM   3657 C CD1 . ILE A 1 509 ? -7.371  -14.833 3.136   1.00 33.85  ? 509 ILE A CD1 1 
ATOM   3658 N N   . THR A 1 510 ? -9.075  -20.228 4.518   1.00 33.55  ? 510 THR A N   1 
ATOM   3659 C CA  . THR A 1 510 ? -9.947  -21.394 4.472   1.00 33.52  ? 510 THR A CA  1 
ATOM   3660 C C   . THR A 1 510 ? -11.366 -21.024 4.882   1.00 30.61  ? 510 THR A C   1 
ATOM   3661 O O   . THR A 1 510 ? -11.589 -20.445 5.951   1.00 32.15  ? 510 THR A O   1 
ATOM   3662 C CB  . THR A 1 510 ? -9.413  -22.496 5.382   1.00 41.16  ? 510 THR A CB  1 
ATOM   3663 O OG1 . THR A 1 510 ? -8.012  -22.656 5.140   1.00 43.61  ? 510 THR A OG1 1 
ATOM   3664 C CG2 . THR A 1 510 ? -10.104 -23.804 5.082   1.00 33.52  ? 510 THR A CG2 1 
ATOM   3665 N N   . GLN A 1 511 ? -12.321 -21.386 4.043   1.00 31.81  ? 511 GLN A N   1 
ATOM   3666 C CA  . GLN A 1 511 ? -13.728 -21.099 4.264   1.00 32.05  ? 511 GLN A CA  1 
ATOM   3667 C C   . GLN A 1 511 ? -14.415 -22.383 4.675   1.00 29.19  ? 511 GLN A C   1 
ATOM   3668 O O   . GLN A 1 511 ? -14.393 -23.356 3.924   1.00 31.45  ? 511 GLN A O   1 
ATOM   3669 C CB  . GLN A 1 511 ? -14.351 -20.543 2.993   1.00 31.54  ? 511 GLN A CB  1 
ATOM   3670 C CG  . GLN A 1 511 ? -14.040 -19.110 2.742   1.00 30.09  ? 511 GLN A CG  1 
ATOM   3671 C CD  . GLN A 1 511 ? -14.897 -18.573 1.628   1.00 35.60  ? 511 GLN A CD  1 
ATOM   3672 O OE1 . GLN A 1 511 ? -15.282 -19.319 0.726   1.00 30.26  ? 511 GLN A OE1 1 
ATOM   3673 N NE2 . GLN A 1 511 ? -15.276 -17.297 1.722   1.00 34.48  ? 511 GLN A NE2 1 
ATOM   3674 N N   . LEU A 1 512 ? -15.004 -22.397 5.854   1.00 27.64  ? 512 LEU A N   1 
ATOM   3675 C CA  . LEU A 1 512 ? -15.664 -23.602 6.330   1.00 31.65  ? 512 LEU A CA  1 
ATOM   3676 C C   . LEU A 1 512 ? -17.155 -23.332 6.373   1.00 35.91  ? 512 LEU A C   1 
ATOM   3677 O O   . LEU A 1 512 ? -17.613 -22.551 7.225   1.00 36.38  ? 512 LEU A O   1 
ATOM   3678 C CB  . LEU A 1 512 ? -15.158 -23.996 7.715   1.00 39.29  ? 512 LEU A CB  1 
ATOM   3679 C CG  . LEU A 1 512 ? -13.961 -24.919 7.956   1.00 43.48  ? 512 LEU A CG  1 
ATOM   3680 C CD1 . LEU A 1 512 ? -13.830 -25.191 9.458   1.00 47.08  ? 512 LEU A CD1 1 
ATOM   3681 C CD2 . LEU A 1 512 ? -14.094 -26.216 7.190   1.00 40.64  ? 512 LEU A CD2 1 
ATOM   3682 N N   . PRO A 1 513 ? -17.950 -23.903 5.478   1.00 32.40  ? 513 PRO A N   1 
ATOM   3683 C CA  . PRO A 1 513 ? -19.384 -23.641 5.531   1.00 31.16  ? 513 PRO A CA  1 
ATOM   3684 C C   . PRO A 1 513 ? -19.967 -24.348 6.734   1.00 35.26  ? 513 PRO A C   1 
ATOM   3685 O O   . PRO A 1 513 ? -19.587 -25.474 7.051   1.00 40.21  ? 513 PRO A O   1 
ATOM   3686 C CB  . PRO A 1 513 ? -19.908 -24.231 4.216   1.00 31.97  ? 513 PRO A CB  1 
ATOM   3687 C CG  . PRO A 1 513 ? -18.716 -24.357 3.351   1.00 34.11  ? 513 PRO A CG  1 
ATOM   3688 C CD  . PRO A 1 513 ? -17.584 -24.678 4.288   1.00 32.49  ? 513 PRO A CD  1 
ATOM   3689 N N   . LEU A 1 514 ? -20.885 -23.679 7.420   1.00 34.28  ? 514 LEU A N   1 
ATOM   3690 C CA  . LEU A 1 514 ? -21.542 -24.302 8.562   1.00 34.85  ? 514 LEU A CA  1 
ATOM   3691 C C   . LEU A 1 514 ? -22.397 -25.516 8.191   1.00 30.91  ? 514 LEU A C   1 
ATOM   3692 O O   . LEU A 1 514 ? -22.773 -26.274 9.082   1.00 34.60  ? 514 LEU A O   1 
ATOM   3693 C CB  . LEU A 1 514 ? -22.366 -23.238 9.298   1.00 40.04  ? 514 LEU A CB  1 
ATOM   3694 C CG  . LEU A 1 514 ? -21.620 -22.546 10.444  1.00 42.91  ? 514 LEU A CG  1 
ATOM   3695 C CD1 . LEU A 1 514 ? -21.653 -23.411 11.663  1.00 35.56  ? 514 LEU A CD1 1 
ATOM   3696 C CD2 . LEU A 1 514 ? -20.146 -22.366 10.053  1.00 38.78  ? 514 LEU A CD2 1 
ATOM   3697 N N   . VAL A 1 515 ? -22.685 -25.761 6.915   1.00 29.12  ? 515 VAL A N   1 
ATOM   3698 C CA  . VAL A 1 515 ? -23.383 -26.995 6.579   1.00 31.65  ? 515 VAL A CA  1 
ATOM   3699 C C   . VAL A 1 515 ? -22.489 -28.239 6.654   1.00 37.17  ? 515 VAL A C   1 
ATOM   3700 O O   . VAL A 1 515 ? -23.000 -29.362 6.525   1.00 31.55  ? 515 VAL A O   1 
ATOM   3701 C CB  . VAL A 1 515 ? -24.014 -26.888 5.180   1.00 29.26  ? 515 VAL A CB  1 
ATOM   3702 C CG1 . VAL A 1 515 ? -25.030 -25.754 5.130   1.00 30.97  ? 515 VAL A CG1 1 
ATOM   3703 C CG2 . VAL A 1 515 ? -22.941 -26.698 4.148   1.00 33.13  ? 515 VAL A CG2 1 
ATOM   3704 N N   . LYS A 1 516 ? -21.169 -28.084 6.853   1.00 33.40  ? 516 LYS A N   1 
ATOM   3705 C CA  . LYS A 1 516 ? -20.286 -29.225 7.046   1.00 32.89  ? 516 LYS A CA  1 
ATOM   3706 C C   . LYS A 1 516 ? -20.172 -29.616 8.511   1.00 41.37  ? 516 LYS A C   1 
ATOM   3707 O O   . LYS A 1 516 ? -19.551 -30.648 8.831   1.00 41.79  ? 516 LYS A O   1 
ATOM   3708 C CB  . LYS A 1 516 ? -18.892 -28.937 6.489   1.00 31.84  ? 516 LYS A CB  1 
ATOM   3709 C CG  . LYS A 1 516 ? -18.850 -28.507 5.038   1.00 33.39  ? 516 LYS A CG  1 
ATOM   3710 C CD  . LYS A 1 516 ? -19.282 -29.589 4.076   1.00 37.50  ? 516 LYS A CD  1 
ATOM   3711 C CE  . LYS A 1 516 ? -18.278 -30.690 4.103   1.00 39.47  ? 516 LYS A CE  1 
ATOM   3712 N NZ  . LYS A 1 516 ? -16.970 -30.055 3.862   1.00 42.42  ? 516 LYS A NZ  1 
ATOM   3713 N N   . ALA A 1 517 ? -20.739 -28.812 9.405   1.00 35.12  ? 517 ALA A N   1 
ATOM   3714 C CA  . ALA A 1 517 ? -20.967 -29.270 10.763  1.00 43.64  ? 517 ALA A CA  1 
ATOM   3715 C C   . ALA A 1 517 ? -21.628 -30.640 10.745  1.00 41.93  ? 517 ALA A C   1 
ATOM   3716 O O   . ALA A 1 517 ? -22.447 -30.931 9.875   1.00 45.05  ? 517 ALA A O   1 
ATOM   3717 C CB  . ALA A 1 517 ? -21.848 -28.263 11.510  1.00 46.36  ? 517 ALA A CB  1 
ATOM   3718 N N   . TYR A 1 518 ? -21.272 -31.492 11.698  1.00 42.15  ? 518 TYR A N   1 
ATOM   3719 C CA  . TYR A 1 518 ? -21.885 -32.811 11.783  1.00 40.95  ? 518 TYR A CA  1 
ATOM   3720 C C   . TYR A 1 518 ? -23.061 -32.897 12.761  1.00 50.78  ? 518 TYR A C   1 
ATOM   3721 O O   . TYR A 1 518 ? -23.546 -34.006 13.010  1.00 51.86  ? 518 TYR A O   1 
ATOM   3722 C CB  . TYR A 1 518 ? -20.835 -33.850 12.163  1.00 44.21  ? 518 TYR A CB  1 
ATOM   3723 C CG  . TYR A 1 518 ? -20.212 -33.603 13.521  1.00 48.22  ? 518 TYR A CG  1 
ATOM   3724 C CD1 . TYR A 1 518 ? -20.905 -33.886 14.697  1.00 43.08  ? 518 TYR A CD1 1 
ATOM   3725 C CD2 . TYR A 1 518 ? -18.895 -33.164 13.625  1.00 48.28  ? 518 TYR A CD2 1 
ATOM   3726 C CE1 . TYR A 1 518 ? -20.355 -33.667 15.918  1.00 39.32  ? 518 TYR A CE1 1 
ATOM   3727 C CE2 . TYR A 1 518 ? -18.314 -32.975 14.857  1.00 47.68  ? 518 TYR A CE2 1 
ATOM   3728 C CZ  . TYR A 1 518 ? -19.056 -33.225 15.998  1.00 46.81  ? 518 TYR A CZ  1 
ATOM   3729 O OH  . TYR A 1 518 ? -18.498 -33.015 17.229  1.00 51.56  ? 518 TYR A OH  1 
ATOM   3730 N N   . LYS A 1 519 ? -23.553 -31.763 13.288  1.00 55.00  ? 519 LYS A N   1 
ATOM   3731 C CA  . LYS A 1 519 ? -24.391 -31.733 14.488  1.00 47.34  ? 519 LYS A CA  1 
ATOM   3732 C C   . LYS A 1 519 ? -24.939 -30.331 14.726  1.00 45.60  ? 519 LYS A C   1 
ATOM   3733 O O   . LYS A 1 519 ? -24.181 -29.361 14.664  1.00 48.14  ? 519 LYS A O   1 
ATOM   3734 C CB  . LYS A 1 519 ? -23.551 -32.203 15.685  1.00 50.01  ? 519 LYS A CB  1 
ATOM   3735 C CG  . LYS A 1 519 ? -24.090 -31.992 17.103  1.00 51.39  ? 519 LYS A CG  1 
ATOM   3736 C CD  . LYS A 1 519 ? -22.882 -32.072 18.056  1.00 52.39  ? 519 LYS A CD  1 
ATOM   3737 C CE  . LYS A 1 519 ? -23.197 -32.351 19.514  1.00 48.30  ? 519 LYS A CE  1 
ATOM   3738 N NZ  . LYS A 1 519 ? -21.921 -32.219 20.292  1.00 33.36  ? 519 LYS A NZ  1 
ATOM   3739 N N   . LEU A 1 520 ? -26.236 -30.196 15.007  1.00 48.08  ? 520 LEU A N   1 
ATOM   3740 C CA  . LEU A 1 520 ? -26.823 -28.894 15.315  1.00 49.87  ? 520 LEU A CA  1 
ATOM   3741 C C   . LEU A 1 520 ? -27.597 -28.968 16.620  1.00 51.67  ? 520 LEU A C   1 
ATOM   3742 O O   . LEU A 1 520 ? -28.275 -29.959 16.904  1.00 55.75  ? 520 LEU A O   1 
ATOM   3743 C CB  . LEU A 1 520 ? -27.777 -28.411 14.234  1.00 48.39  ? 520 LEU A CB  1 
ATOM   3744 C CG  . LEU A 1 520 ? -27.268 -28.276 12.815  1.00 44.93  ? 520 LEU A CG  1 
ATOM   3745 C CD1 . LEU A 1 520 ? -28.454 -28.017 11.924  1.00 39.22  ? 520 LEU A CD1 1 
ATOM   3746 C CD2 . LEU A 1 520 ? -26.278 -27.133 12.768  1.00 43.91  ? 520 LEU A CD2 1 
ATOM   3747 N N   . GLN A 1 521 ? -27.534 -27.886 17.385  1.00 51.67  ? 521 GLN A N   1 
ATOM   3748 C CA  . GLN A 1 521 ? -28.136 -27.857 18.705  1.00 56.00  ? 521 GLN A CA  1 
ATOM   3749 C C   . GLN A 1 521 ? -28.882 -26.544 18.931  1.00 59.72  ? 521 GLN A C   1 
ATOM   3750 O O   . GLN A 1 521 ? -28.837 -25.616 18.112  1.00 58.00  ? 521 GLN A O   1 
ATOM   3751 C CB  . GLN A 1 521 ? -27.082 -28.076 19.801  1.00 54.10  ? 521 GLN A CB  1 
ATOM   3752 C CG  . GLN A 1 521 ? -25.874 -27.167 19.696  1.00 54.61  ? 521 GLN A CG  1 
ATOM   3753 C CD  . GLN A 1 521 ? -24.600 -27.888 19.259  1.00 61.44  ? 521 GLN A CD  1 
ATOM   3754 O OE1 . GLN A 1 521 ? -24.535 -28.505 18.190  1.00 56.68  ? 521 GLN A OE1 1 
ATOM   3755 N NE2 . GLN A 1 521 ? -23.551 -27.763 20.080  1.00 66.00  ? 521 GLN A NE2 1 
ATOM   3756 N N   . SER A 1 522 ? -29.580 -26.498 20.075  1.00 56.73  ? 522 SER A N   1 
ATOM   3757 C CA  . SER A 1 522 ? -30.360 -25.345 20.530  1.00 48.88  ? 522 SER A CA  1 
ATOM   3758 C C   . SER A 1 522 ? -31.408 -24.925 19.509  1.00 49.63  ? 522 SER A C   1 
ATOM   3759 O O   . SER A 1 522 ? -31.796 -23.757 19.440  1.00 52.05  ? 522 SER A O   1 
ATOM   3760 C CB  . SER A 1 522 ? -29.461 -24.163 20.894  1.00 50.65  ? 522 SER A CB  1 
ATOM   3761 O OG  . SER A 1 522 ? -28.625 -24.470 21.995  1.00 54.07  ? 522 SER A OG  1 
ATOM   3762 N N   . GLY A 1 523 ? -31.888 -25.869 18.713  1.00 48.76  ? 523 GLY A N   1 
ATOM   3763 C CA  . GLY A 1 523 ? -32.937 -25.535 17.773  1.00 57.65  ? 523 GLY A CA  1 
ATOM   3764 C C   . GLY A 1 523 ? -32.415 -24.732 16.604  1.00 58.81  ? 523 GLY A C   1 
ATOM   3765 O O   . GLY A 1 523 ? -33.013 -23.723 16.203  1.00 60.16  ? 523 GLY A O   1 
ATOM   3766 N N   . ALA A 1 524 ? -31.284 -25.186 16.064  1.00 54.38  ? 524 ALA A N   1 
ATOM   3767 C CA  . ALA A 1 524 ? -30.615 -24.551 14.939  1.00 47.19  ? 524 ALA A CA  1 
ATOM   3768 C C   . ALA A 1 524 ? -30.885 -25.390 13.701  1.00 43.81  ? 524 ALA A C   1 
ATOM   3769 O O   . ALA A 1 524 ? -30.520 -26.564 13.662  1.00 46.97  ? 524 ALA A O   1 
ATOM   3770 C CB  . ALA A 1 524 ? -29.117 -24.446 15.210  1.00 45.52  ? 524 ALA A CB  1 
ATOM   3771 N N   . SER A 1 525 ? -31.532 -24.811 12.703  1.00 40.54  ? 525 SER A N   1 
ATOM   3772 C CA  . SER A 1 525 ? -31.891 -25.605 11.539  1.00 37.16  ? 525 SER A CA  1 
ATOM   3773 C C   . SER A 1 525 ? -31.095 -25.183 10.314  1.00 37.48  ? 525 SER A C   1 
ATOM   3774 O O   . SER A 1 525 ? -30.370 -24.184 10.303  1.00 37.53  ? 525 SER A O   1 
ATOM   3775 C CB  . SER A 1 525 ? -33.384 -25.508 11.232  1.00 40.74  ? 525 SER A CB  1 
ATOM   3776 O OG  . SER A 1 525 ? -33.727 -24.217 10.773  1.00 46.17  ? 525 SER A OG  1 
ATOM   3777 N N   . VAL A 1 526 ? -31.233 -25.984 9.269   1.00 41.41  ? 526 VAL A N   1 
ATOM   3778 C CA  . VAL A 1 526 ? -30.588 -25.732 7.987   1.00 39.51  ? 526 VAL A CA  1 
ATOM   3779 C C   . VAL A 1 526 ? -31.592 -25.077 7.066   1.00 37.95  ? 526 VAL A C   1 
ATOM   3780 O O   . VAL A 1 526 ? -32.709 -25.576 6.901   1.00 47.04  ? 526 VAL A O   1 
ATOM   3781 C CB  . VAL A 1 526 ? -30.028 -27.023 7.377   1.00 36.33  ? 526 VAL A CB  1 
ATOM   3782 C CG1 . VAL A 1 526 ? -29.514 -26.751 6.003   1.00 37.12  ? 526 VAL A CG1 1 
ATOM   3783 C CG2 . VAL A 1 526 ? -28.876 -27.440 8.205   1.00 32.56  ? 526 VAL A CG2 1 
ATOM   3784 N N   . VAL A 1 527 ? -31.196 -23.966 6.461   1.00 36.29  ? 527 VAL A N   1 
ATOM   3785 C CA  . VAL A 1 527 ? -32.121 -23.105 5.750   1.00 31.95  ? 527 VAL A CA  1 
ATOM   3786 C C   . VAL A 1 527 ? -31.595 -22.852 4.343   1.00 33.91  ? 527 VAL A C   1 
ATOM   3787 O O   . VAL A 1 527 ? -30.379 -22.808 4.102   1.00 27.93  ? 527 VAL A O   1 
ATOM   3788 C CB  . VAL A 1 527 ? -32.324 -21.806 6.542   1.00 32.64  ? 527 VAL A CB  1 
ATOM   3789 C CG1 . VAL A 1 527 ? -32.743 -20.647 5.645   1.00 38.37  ? 527 VAL A CG1 1 
ATOM   3790 C CG2 . VAL A 1 527 ? -33.309 -22.058 7.626   1.00 30.94  ? 527 VAL A CG2 1 
ATOM   3791 N N   . ALA A 1 528 ? -32.534 -22.744 3.400   1.00 33.61  ? 528 ALA A N   1 
ATOM   3792 C CA  . ALA A 1 528 ? -32.207 -22.390 2.023   1.00 33.12  ? 528 ALA A CA  1 
ATOM   3793 C C   . ALA A 1 528 ? -31.335 -21.146 1.985   1.00 30.35  ? 528 ALA A C   1 
ATOM   3794 O O   . ALA A 1 528 ? -31.738 -20.071 2.439   1.00 38.88  ? 528 ALA A O   1 
ATOM   3795 C CB  . ALA A 1 528 ? -33.491 -22.159 1.223   1.00 28.75  ? 528 ALA A CB  1 
ATOM   3796 N N   . GLY A 1 529 ? -30.137 -21.291 1.470   1.00 26.57  ? 529 GLY A N   1 
ATOM   3797 C CA  . GLY A 1 529 ? -29.281 -20.155 1.300   1.00 28.65  ? 529 GLY A CA  1 
ATOM   3798 C C   . GLY A 1 529 ? -29.868 -19.148 0.345   1.00 25.53  ? 529 GLY A C   1 
ATOM   3799 O O   . GLY A 1 529 ? -30.754 -19.441 -0.458  1.00 29.64  ? 529 GLY A O   1 
ATOM   3800 N N   . PRO A 1 530 ? -29.376 -17.951 0.408   1.00 27.76  ? 530 PRO A N   1 
ATOM   3801 C CA  . PRO A 1 530 ? -29.949 -16.876 -0.398  1.00 23.80  ? 530 PRO A CA  1 
ATOM   3802 C C   . PRO A 1 530 ? -29.480 -16.852 -1.842  1.00 24.84  ? 530 PRO A C   1 
ATOM   3803 O O   . PRO A 1 530 ? -29.654 -15.839 -2.518  1.00 30.20  ? 530 PRO A O   1 
ATOM   3804 C CB  . PRO A 1 530 ? -29.492 -15.627 0.358   1.00 26.37  ? 530 PRO A CB  1 
ATOM   3805 C CG  . PRO A 1 530 ? -28.167 -16.017 0.905   1.00 27.67  ? 530 PRO A CG  1 
ATOM   3806 C CD  . PRO A 1 530 ? -28.270 -17.475 1.255   1.00 29.32  ? 530 PRO A CD  1 
ATOM   3807 N N   . ARG A 1 531 ? -28.881 -17.932 -2.330  1.00 32.59  ? 531 ARG A N   1 
ATOM   3808 C CA  . ARG A 1 531 ? -28.554 -18.209 -3.734  1.00 32.55  ? 531 ARG A CA  1 
ATOM   3809 C C   . ARG A 1 531 ? -27.159 -17.743 -4.118  1.00 30.90  ? 531 ARG A C   1 
ATOM   3810 O O   . ARG A 1 531 ? -26.681 -18.118 -5.193  1.00 29.06  ? 531 ARG A O   1 
ATOM   3811 C CB  . ARG A 1 531 ? -29.557 -17.605 -4.726  1.00 24.71  ? 531 ARG A CB  1 
ATOM   3812 C CG  . ARG A 1 531 ? -30.960 -18.086 -4.569  1.00 32.82  ? 531 ARG A CG  1 
ATOM   3813 C CD  . ARG A 1 531 ? -31.128 -19.511 -5.050  1.00 44.94  ? 531 ARG A CD  1 
ATOM   3814 N NE  . ARG A 1 531 ? -32.525 -19.935 -4.925  1.00 58.07  ? 531 ARG A NE  1 
ATOM   3815 C CZ  . ARG A 1 531 ? -33.013 -20.564 -3.860  1.00 65.41  ? 531 ARG A CZ  1 
ATOM   3816 N NH1 . ARG A 1 531 ? -32.192 -20.897 -2.841  1.00 41.71  ? 531 ARG A NH1 1 
ATOM   3817 N NH2 . ARG A 1 531 ? -34.310 -20.884 -3.841  1.00 56.44  ? 531 ARG A NH2 1 
ATOM   3818 N N   . PHE A 1 532 ? -26.493 -16.929 -3.287  1.00 31.06  ? 532 PHE A N   1 
ATOM   3819 C CA  . PHE A 1 532 ? -25.171 -16.411 -3.617  1.00 30.02  ? 532 PHE A CA  1 
ATOM   3820 C C   . PHE A 1 532 ? -24.065 -16.924 -2.709  1.00 29.55  ? 532 PHE A C   1 
ATOM   3821 O O   . PHE A 1 532 ? -22.903 -16.569 -2.930  1.00 30.53  ? 532 PHE A O   1 
ATOM   3822 C CB  . PHE A 1 532 ? -25.170 -14.869 -3.635  1.00 27.88  ? 532 PHE A CB  1 
ATOM   3823 C CG  . PHE A 1 532 ? -25.510 -14.214 -2.309  1.00 31.81  ? 532 PHE A CG  1 
ATOM   3824 C CD1 . PHE A 1 532 ? -24.547 -14.076 -1.297  1.00 29.87  ? 532 PHE A CD1 1 
ATOM   3825 C CD2 . PHE A 1 532 ? -26.797 -13.709 -2.079  1.00 26.47  ? 532 PHE A CD2 1 
ATOM   3826 C CE1 . PHE A 1 532 ? -24.872 -13.461 -0.080  1.00 24.55  ? 532 PHE A CE1 1 
ATOM   3827 C CE2 . PHE A 1 532 ? -27.118 -13.099 -0.875  1.00 23.88  ? 532 PHE A CE2 1 
ATOM   3828 C CZ  . PHE A 1 532 ? -26.151 -12.976 0.130   1.00 23.74  ? 532 PHE A CZ  1 
ATOM   3829 N N   . THR A 1 533 ? -24.380 -17.763 -1.716  1.00 33.42  ? 533 THR A N   1 
ATOM   3830 C CA  . THR A 1 533 ? -23.371 -18.300 -0.807  1.00 30.17  ? 533 THR A CA  1 
ATOM   3831 C C   . THR A 1 533 ? -22.763 -19.600 -1.288  1.00 30.42  ? 533 THR A C   1 
ATOM   3832 O O   . THR A 1 533 ? -21.825 -20.090 -0.652  1.00 33.65  ? 533 THR A O   1 
ATOM   3833 C CB  . THR A 1 533 ? -23.949 -18.567 0.586   1.00 35.71  ? 533 THR A CB  1 
ATOM   3834 O OG1 . THR A 1 533 ? -24.995 -19.549 0.476   1.00 41.11  ? 533 THR A OG1 1 
ATOM   3835 C CG2 . THR A 1 533 ? -24.464 -17.280 1.248   1.00 32.19  ? 533 THR A CG2 1 
ATOM   3836 N N   . GLY A 1 534 ? -23.273 -20.186 -2.363  1.00 29.00  ? 534 GLY A N   1 
ATOM   3837 C CA  . GLY A 1 534 ? -22.765 -21.467 -2.798  1.00 25.65  ? 534 GLY A CA  1 
ATOM   3838 C C   . GLY A 1 534 ? -23.451 -22.627 -2.145  1.00 27.09  ? 534 GLY A C   1 
ATOM   3839 O O   . GLY A 1 534 ? -22.991 -23.765 -2.277  1.00 31.89  ? 534 GLY A O   1 
ATOM   3840 N N   . GLY A 1 535 ? -24.536 -22.375 -1.446  1.00 32.00  ? 535 GLY A N   1 
ATOM   3841 C CA  . GLY A 1 535 ? -25.269 -23.409 -0.751  1.00 32.31  ? 535 GLY A CA  1 
ATOM   3842 C C   . GLY A 1 535 ? -26.167 -22.788 0.306   1.00 30.65  ? 535 GLY A C   1 
ATOM   3843 O O   . GLY A 1 535 ? -26.643 -21.657 0.156   1.00 29.46  ? 535 GLY A O   1 
ATOM   3844 N N   . ASP A 1 536 ? -26.360 -23.546 1.368   1.00 31.84  ? 536 ASP A N   1 
ATOM   3845 C CA  . ASP A 1 536 ? -27.280 -23.170 2.413   1.00 31.12  ? 536 ASP A CA  1 
ATOM   3846 C C   . ASP A 1 536 ? -26.510 -22.610 3.602   1.00 32.62  ? 536 ASP A C   1 
ATOM   3847 O O   . ASP A 1 536 ? -25.282 -22.469 3.590   1.00 32.97  ? 536 ASP A O   1 
ATOM   3848 C CB  . ASP A 1 536 ? -28.137 -24.368 2.809   1.00 33.16  ? 536 ASP A CB  1 
ATOM   3849 C CG  . ASP A 1 536 ? -28.909 -24.941 1.639   1.00 38.14  ? 536 ASP A CG  1 
ATOM   3850 O OD1 . ASP A 1 536 ? -28.989 -24.258 0.589   1.00 37.32  ? 536 ASP A OD1 1 
ATOM   3851 O OD2 . ASP A 1 536 ? -29.437 -26.078 1.765   1.00 44.55  ? 536 ASP A OD2 1 
ATOM   3852 N N   . ILE A 1 537 ? -27.266 -22.286 4.651   1.00 33.86  ? 537 ILE A N   1 
ATOM   3853 C CA  . ILE A 1 537 ? -26.763 -21.572 5.812   1.00 30.19  ? 537 ILE A CA  1 
ATOM   3854 C C   . ILE A 1 537 ? -27.473 -22.149 7.019   1.00 29.12  ? 537 ILE A C   1 
ATOM   3855 O O   . ILE A 1 537 ? -28.555 -22.728 6.904   1.00 29.76  ? 537 ILE A O   1 
ATOM   3856 C CB  . ILE A 1 537 ? -27.030 -20.052 5.731   1.00 30.70  ? 537 ILE A CB  1 
ATOM   3857 C CG1 . ILE A 1 537 ? -28.480 -19.791 5.348   1.00 31.49  ? 537 ILE A CG1 1 
ATOM   3858 C CG2 . ILE A 1 537 ? -26.172 -19.426 4.651   1.00 33.15  ? 537 ILE A CG2 1 
ATOM   3859 C CD1 . ILE A 1 537 ? -28.812 -18.353 5.256   1.00 30.87  ? 537 ILE A CD1 1 
ATOM   3860 N N   . ILE A 1 538 ? -26.875 -21.956 8.189   1.00 33.23  ? 538 ILE A N   1 
ATOM   3861 C CA  . ILE A 1 538 ? -27.464 -22.433 9.433   1.00 33.34  ? 538 ILE A CA  1 
ATOM   3862 C C   . ILE A 1 538 ? -28.305 -21.311 10.010  1.00 34.70  ? 538 ILE A C   1 
ATOM   3863 O O   . ILE A 1 538 ? -27.862 -20.155 10.056  1.00 34.10  ? 538 ILE A O   1 
ATOM   3864 C CB  . ILE A 1 538 ? -26.383 -22.870 10.429  1.00 34.04  ? 538 ILE A CB  1 
ATOM   3865 C CG1 . ILE A 1 538 ? -26.025 -24.333 10.228  1.00 34.77  ? 538 ILE A CG1 1 
ATOM   3866 C CG2 . ILE A 1 538 ? -26.871 -22.670 11.850  1.00 34.35  ? 538 ILE A CG2 1 
ATOM   3867 C CD1 . ILE A 1 538 ? -25.660 -24.674 8.806   1.00 31.64  ? 538 ILE A CD1 1 
ATOM   3868 N N   . GLN A 1 539 ? -29.513 -21.648 10.449  1.00 37.18  ? 539 GLN A N   1 
ATOM   3869 C CA  . GLN A 1 539 ? -30.427 -20.694 11.065  1.00 41.37  ? 539 GLN A CA  1 
ATOM   3870 C C   . GLN A 1 539 ? -30.505 -20.937 12.573  1.00 45.46  ? 539 GLN A C   1 
ATOM   3871 O O   . GLN A 1 539 ? -31.026 -21.976 13.008  1.00 44.52  ? 539 GLN A O   1 
ATOM   3872 C CB  . GLN A 1 539 ? -31.823 -20.797 10.452  1.00 38.20  ? 539 GLN A CB  1 
ATOM   3873 C CG  . GLN A 1 539 ? -32.713 -19.618 10.836  1.00 48.02  ? 539 GLN A CG  1 
ATOM   3874 C CD  . GLN A 1 539 ? -34.188 -19.905 10.669  1.00 48.44  ? 539 GLN A CD  1 
ATOM   3875 O OE1 . GLN A 1 539 ? -34.623 -21.035 10.886  1.00 53.40  ? 539 GLN A OE1 1 
ATOM   3876 N NE2 . GLN A 1 539 ? -34.968 -18.885 10.281  1.00 43.20  ? 539 GLN A NE2 1 
ATOM   3877 N N   . CYS A 1 540 ? -30.028 -19.959 13.357  1.00 36.69  ? 540 CYS A N   1 
ATOM   3878 C CA  . CYS A 1 540 ? -30.146 -19.941 14.810  1.00 35.23  ? 540 CYS A CA  1 
ATOM   3879 C C   . CYS A 1 540 ? -31.343 -19.105 15.231  1.00 41.38  ? 540 CYS A C   1 
ATOM   3880 O O   . CYS A 1 540 ? -31.480 -17.962 14.797  1.00 45.29  ? 540 CYS A O   1 
ATOM   3881 C CB  . CYS A 1 540 ? -28.896 -19.349 15.427  1.00 39.12  ? 540 CYS A CB  1 
ATOM   3882 S SG  . CYS A 1 540 ? -27.415 -20.078 14.780  1.00 49.38  ? 540 CYS A SG  1 
ATOM   3883 N N   . THR A 1 541 ? -32.199 -19.659 16.092  1.00 50.08  ? 541 THR A N   1 
ATOM   3884 C CA  . THR A 1 541 ? -33.353 -18.925 16.620  1.00 50.88  ? 541 THR A CA  1 
ATOM   3885 C C   . THR A 1 541 ? -33.329 -18.816 18.136  1.00 49.65  ? 541 THR A C   1 
ATOM   3886 O O   . THR A 1 541 ? -34.304 -18.364 18.737  1.00 47.05  ? 541 THR A O   1 
ATOM   3887 C CB  . THR A 1 541 ? -34.658 -19.593 16.196  1.00 47.46  ? 541 THR A CB  1 
ATOM   3888 O OG1 . THR A 1 541 ? -34.690 -20.920 16.740  1.00 42.99  ? 541 THR A OG1 1 
ATOM   3889 C CG2 . THR A 1 541 ? -34.752 -19.644 14.688  1.00 49.33  ? 541 THR A CG2 1 
ATOM   3890 N N   . GLU A 1 542 ? -32.240 -19.225 18.764  1.00 49.25  ? 542 GLU A N   1 
ATOM   3891 C CA  . GLU A 1 542 ? -32.207 -19.429 20.190  1.00 45.66  ? 542 GLU A CA  1 
ATOM   3892 C C   . GLU A 1 542 ? -30.799 -19.158 20.656  1.00 44.19  ? 542 GLU A C   1 
ATOM   3893 O O   . GLU A 1 542 ? -29.827 -19.417 19.941  1.00 44.81  ? 542 GLU A O   1 
ATOM   3894 C CB  . GLU A 1 542 ? -32.608 -20.862 20.571  1.00 52.34  ? 542 GLU A CB  1 
ATOM   3895 C CG  . GLU A 1 542 ? -34.109 -21.161 20.550  1.00 57.43  ? 542 GLU A CG  1 
ATOM   3896 C CD  . GLU A 1 542 ? -34.482 -22.326 21.485  1.00 75.04  ? 542 GLU A CD  1 
ATOM   3897 O OE1 . GLU A 1 542 ? -34.253 -22.179 22.708  1.00 85.77  ? 542 GLU A OE1 1 
ATOM   3898 O OE2 . GLU A 1 542 ? -35.019 -23.373 21.013  1.00 68.91  ? 542 GLU A OE2 1 
ATOM   3899 N N   . ASN A 1 543 ? -30.706 -18.650 21.874  1.00 45.40  ? 543 ASN A N   1 
ATOM   3900 C CA  . ASN A 1 543 ? -29.422 -18.485 22.523  1.00 44.64  ? 543 ASN A CA  1 
ATOM   3901 C C   . ASN A 1 543 ? -28.725 -19.823 22.747  1.00 48.23  ? 543 ASN A C   1 
ATOM   3902 O O   . ASN A 1 543 ? -29.352 -20.860 23.003  1.00 46.85  ? 543 ASN A O   1 
ATOM   3903 C CB  . ASN A 1 543 ? -29.639 -17.760 23.831  1.00 47.24  ? 543 ASN A CB  1 
ATOM   3904 C CG  . ASN A 1 543 ? -29.909 -16.317 23.614  1.00 49.92  ? 543 ASN A CG  1 
ATOM   3905 O OD1 . ASN A 1 543 ? -29.640 -15.799 22.535  1.00 50.35  ? 543 ASN A OD1 1 
ATOM   3906 N ND2 . ASN A 1 543 ? -30.499 -15.660 24.600  1.00 52.47  ? 543 ASN A ND2 1 
ATOM   3907 N N   . GLY A 1 544 ? -27.412 -19.794 22.632  1.00 45.28  ? 544 GLY A N   1 
ATOM   3908 C CA  . GLY A 1 544 ? -26.604 -20.937 22.983  1.00 45.14  ? 544 GLY A CA  1 
ATOM   3909 C C   . GLY A 1 544 ? -26.034 -21.627 21.762  1.00 53.37  ? 544 GLY A C   1 
ATOM   3910 O O   . GLY A 1 544 ? -26.279 -21.252 20.611  1.00 53.46  ? 544 GLY A O   1 
ATOM   3911 N N   . SER A 1 545 ? -25.272 -22.677 22.072  1.00 59.83  ? 545 SER A N   1 
ATOM   3912 C CA  . SER A 1 545 ? -24.488 -23.394 21.080  1.00 58.91  ? 545 SER A CA  1 
ATOM   3913 C C   . SER A 1 545 ? -25.367 -23.778 19.905  1.00 61.92  ? 545 SER A C   1 
ATOM   3914 O O   . SER A 1 545 ? -26.496 -24.242 20.084  1.00 63.70  ? 545 SER A O   1 
ATOM   3915 C CB  . SER A 1 545 ? -23.864 -24.634 21.714  1.00 63.98  ? 545 SER A CB  1 
ATOM   3916 O OG  . SER A 1 545 ? -23.093 -24.281 22.863  1.00 68.03  ? 545 SER A OG  1 
ATOM   3917 N N   . ALA A 1 546 ? -24.862 -23.543 18.701  1.00 58.25  ? 546 ALA A N   1 
ATOM   3918 C CA  . ALA A 1 546 ? -25.686 -23.714 17.514  1.00 56.03  ? 546 ALA A CA  1 
ATOM   3919 C C   . ALA A 1 546 ? -25.167 -24.769 16.554  1.00 54.90  ? 546 ALA A C   1 
ATOM   3920 O O   . ALA A 1 546 ? -25.968 -25.518 15.984  1.00 59.68  ? 546 ALA A O   1 
ATOM   3921 C CB  . ALA A 1 546 ? -25.826 -22.375 16.787  1.00 56.45  ? 546 ALA A CB  1 
ATOM   3922 N N   . ALA A 1 547 ? -23.857 -24.868 16.355  1.00 47.48  ? 547 ALA A N   1 
ATOM   3923 C CA  . ALA A 1 547 ? -23.365 -25.847 15.404  1.00 45.38  ? 547 ALA A CA  1 
ATOM   3924 C C   . ALA A 1 547 ? -21.980 -26.325 15.796  1.00 48.62  ? 547 ALA A C   1 
ATOM   3925 O O   . ALA A 1 547 ? -21.210 -25.608 16.440  1.00 51.44  ? 547 ALA A O   1 
ATOM   3926 C CB  . ALA A 1 547 ? -23.326 -25.288 13.987  1.00 47.09  ? 547 ALA A CB  1 
ATOM   3927 N N   . THR A 1 548 ? -21.675 -27.548 15.387  1.00 45.80  ? 548 THR A N   1 
ATOM   3928 C CA  . THR A 1 548 ? -20.423 -28.190 15.730  1.00 42.54  ? 548 THR A CA  1 
ATOM   3929 C C   . THR A 1 548 ? -19.914 -28.856 14.477  1.00 47.96  ? 548 THR A C   1 
ATOM   3930 O O   . THR A 1 548 ? -20.588 -29.733 13.922  1.00 45.16  ? 548 THR A O   1 
ATOM   3931 C CB  . THR A 1 548 ? -20.599 -29.228 16.823  1.00 46.44  ? 548 THR A CB  1 
ATOM   3932 O OG1 . THR A 1 548 ? -21.169 -28.605 17.972  1.00 54.79  ? 548 THR A OG1 1 
ATOM   3933 C CG2 . THR A 1 548 ? -19.256 -29.830 17.185  1.00 40.57  ? 548 THR A CG2 1 
ATOM   3934 N N   . ILE A 1 549 ? -18.728 -28.444 14.058  1.00 44.14  ? 549 ILE A N   1 
ATOM   3935 C CA  . ILE A 1 549 ? -18.084 -28.927 12.851  1.00 42.42  ? 549 ILE A CA  1 
ATOM   3936 C C   . ILE A 1 549 ? -16.737 -29.504 13.243  1.00 38.69  ? 549 ILE A C   1 
ATOM   3937 O O   . ILE A 1 549 ? -16.049 -28.964 14.113  1.00 37.40  ? 549 ILE A O   1 
ATOM   3938 C CB  . ILE A 1 549 ? -17.947 -27.791 11.814  1.00 40.99  ? 549 ILE A CB  1 
ATOM   3939 C CG1 . ILE A 1 549 ? -17.083 -28.222 10.630  1.00 45.28  ? 549 ILE A CG1 1 
ATOM   3940 C CG2 . ILE A 1 549 ? -17.463 -26.509 12.480  1.00 47.93  ? 549 ILE A CG2 1 
ATOM   3941 C CD1 . ILE A 1 549 ? -17.016 -27.197 9.491   1.00 40.66  ? 549 ILE A CD1 1 
ATOM   3942 N N   . TYR A 1 550 ? -16.392 -30.629 12.642  1.00 43.24  ? 550 TYR A N   1 
ATOM   3943 C CA  . TYR A 1 550 ? -15.105 -31.271 12.854  1.00 45.11  ? 550 TYR A CA  1 
ATOM   3944 C C   . TYR A 1 550 ? -14.096 -30.713 11.851  1.00 44.56  ? 550 TYR A C   1 
ATOM   3945 O O   . TYR A 1 550 ? -14.467 -30.262 10.765  1.00 43.53  ? 550 TYR A O   1 
ATOM   3946 C CB  . TYR A 1 550 ? -15.273 -32.793 12.740  1.00 43.90  ? 550 TYR A CB  1 
ATOM   3947 C CG  . TYR A 1 550 ? -14.050 -33.599 13.088  1.00 42.33  ? 550 TYR A CG  1 
ATOM   3948 C CD1 . TYR A 1 550 ? -13.128 -33.921 12.125  1.00 43.30  ? 550 TYR A CD1 1 
ATOM   3949 C CD2 . TYR A 1 550 ? -13.792 -33.996 14.395  1.00 46.59  ? 550 TYR A CD2 1 
ATOM   3950 C CE1 . TYR A 1 550 ? -11.998 -34.633 12.428  1.00 42.09  ? 550 TYR A CE1 1 
ATOM   3951 C CE2 . TYR A 1 550 ? -12.650 -34.731 14.705  1.00 43.52  ? 550 TYR A CE2 1 
ATOM   3952 C CZ  . TYR A 1 550 ? -11.758 -35.032 13.707  1.00 37.94  ? 550 TYR A CZ  1 
ATOM   3953 O OH  . TYR A 1 550 ? -10.613 -35.737 13.947  1.00 41.78  ? 550 TYR A OH  1 
ATOM   3954 N N   . VAL A 1 551 ? -12.818 -30.715 12.232  1.00 43.71  ? 551 VAL A N   1 
ATOM   3955 C CA  . VAL A 1 551 ? -11.838 -29.814 11.616  1.00 48.46  ? 551 VAL A CA  1 
ATOM   3956 C C   . VAL A 1 551 ? -10.452 -30.461 11.582  1.00 50.64  ? 551 VAL A C   1 
ATOM   3957 O O   . VAL A 1 551 ? -9.922  -30.871 12.619  1.00 52.60  ? 551 VAL A O   1 
ATOM   3958 C CB  . VAL A 1 551 ? -11.812 -28.458 12.366  1.00 42.82  ? 551 VAL A CB  1 
ATOM   3959 C CG1 . VAL A 1 551 ? -10.552 -27.724 12.089  1.00 44.87  ? 551 VAL A CG1 1 
ATOM   3960 C CG2 . VAL A 1 551 ? -12.982 -27.581 11.930  1.00 40.04  ? 551 VAL A CG2 1 
ATOM   3961 N N   . THR A 1 552 ? -9.835  -30.494 10.396  1.00 44.66  ? 552 THR A N   1 
ATOM   3962 C CA  . THR A 1 552 ? -8.547  -31.161 10.225  1.00 45.32  ? 552 THR A CA  1 
ATOM   3963 C C   . THR A 1 552 ? -7.385  -30.189 10.023  1.00 51.71  ? 552 THR A C   1 
ATOM   3964 O O   . THR A 1 552 ? -7.199  -29.654 8.916   1.00 52.01  ? 552 THR A O   1 
ATOM   3965 C CB  . THR A 1 552 ? -8.632  -32.136 9.051   1.00 49.37  ? 552 THR A CB  1 
ATOM   3966 O OG1 . THR A 1 552 ? -9.530  -33.193 9.387   1.00 42.97  ? 552 THR A OG1 1 
ATOM   3967 C CG2 . THR A 1 552 ? -7.263  -32.724 8.723   1.00 56.68  ? 552 THR A CG2 1 
ATOM   3968 N N   . PRO A 1 553 ? -6.563  -29.951 11.042  1.00 48.58  ? 553 PRO A N   1 
ATOM   3969 C CA  . PRO A 1 553 ? -5.355  -29.143 10.844  1.00 51.19  ? 553 PRO A CA  1 
ATOM   3970 C C   . PRO A 1 553 ? -4.307  -29.907 10.062  1.00 59.82  ? 553 PRO A C   1 
ATOM   3971 O O   . PRO A 1 553 ? -4.183  -31.126 10.181  1.00 62.40  ? 553 PRO A O   1 
ATOM   3972 C CB  . PRO A 1 553 ? -4.874  -28.861 12.270  1.00 48.03  ? 553 PRO A CB  1 
ATOM   3973 C CG  . PRO A 1 553 ? -6.036  -29.159 13.138  1.00 54.72  ? 553 PRO A CG  1 
ATOM   3974 C CD  . PRO A 1 553 ? -6.816  -30.238 12.456  1.00 48.52  ? 553 PRO A CD  1 
ATOM   3975 N N   . ASP A 1 554 ? -3.526  -29.176 9.267   1.00 61.07  ? 554 ASP A N   1 
ATOM   3976 C CA  . ASP A 1 554 ? -2.598  -29.837 8.358   1.00 70.48  ? 554 ASP A CA  1 
ATOM   3977 C C   . ASP A 1 554 ? -1.156  -29.923 8.858   1.00 77.30  ? 554 ASP A C   1 
ATOM   3978 O O   . ASP A 1 554 ? -0.346  -30.630 8.244   1.00 78.65  ? 554 ASP A O   1 
ATOM   3979 C CB  . ASP A 1 554 ? -2.647  -29.177 6.972   1.00 69.20  ? 554 ASP A CB  1 
ATOM   3980 C CG  . ASP A 1 554 ? -1.972  -27.835 6.924   1.00 63.63  ? 554 ASP A CG  1 
ATOM   3981 O OD1 . ASP A 1 554 ? -1.584  -27.318 7.993   1.00 66.11  ? 554 ASP A OD1 1 
ATOM   3982 O OD2 . ASP A 1 554 ? -1.804  -27.326 5.788   1.00 57.81  ? 554 ASP A OD2 1 
ATOM   3983 N N   . VAL A 1 555 ? -0.806  -29.233 9.943   1.00 81.20  ? 555 VAL A N   1 
ATOM   3984 C CA  . VAL A 1 555 ? 0.495   -29.390 10.589  1.00 90.67  ? 555 VAL A CA  1 
ATOM   3985 C C   . VAL A 1 555 ? 0.279   -29.308 12.095  1.00 96.81  ? 555 VAL A C   1 
ATOM   3986 O O   . VAL A 1 555 ? -0.806  -28.957 12.576  1.00 88.21  ? 555 VAL A O   1 
ATOM   3987 C CB  . VAL A 1 555 ? 1.546   -28.340 10.134  1.00 85.19  ? 555 VAL A CB  1 
ATOM   3988 C CG1 . VAL A 1 555 ? 2.032   -28.606 8.693   1.00 65.19  ? 555 VAL A CG1 1 
ATOM   3989 C CG2 . VAL A 1 555 ? 0.994   -26.913 10.304  1.00 82.02  ? 555 VAL A CG2 1 
ATOM   3990 N N   . SER A 1 556 ? 1.333   -29.655 12.843  1.00 99.99  ? 556 SER A N   1 
ATOM   3991 C CA  . SER A 1 556 ? 1.318   -29.590 14.302  1.00 104.43 ? 556 SER A CA  1 
ATOM   3992 C C   . SER A 1 556 ? 2.469   -28.745 14.858  1.00 104.65 ? 556 SER A C   1 
ATOM   3993 O O   . SER A 1 556 ? 2.845   -28.901 16.030  1.00 102.39 ? 556 SER A O   1 
ATOM   3994 C CB  . SER A 1 556 ? 1.319   -31.000 14.910  1.00 105.96 ? 556 SER A CB  1 
ATOM   3995 O OG  . SER A 1 556 ? 2.540   -31.690 14.689  1.00 107.44 ? 556 SER A OG  1 
ATOM   3996 N N   . TYR A 1 557 ? 3.047   -27.860 14.039  1.00 98.62  ? 557 TYR A N   1 
ATOM   3997 C CA  . TYR A 1 557 ? 3.749   -26.699 14.572  1.00 88.29  ? 557 TYR A CA  1 
ATOM   3998 C C   . TYR A 1 557 ? 2.690   -25.647 14.857  1.00 87.80  ? 557 TYR A C   1 
ATOM   3999 O O   . TYR A 1 557 ? 1.964   -25.249 13.939  1.00 91.40  ? 557 TYR A O   1 
ATOM   4000 C CB  . TYR A 1 557 ? 4.827   -26.186 13.608  1.00 83.52  ? 557 TYR A CB  1 
ATOM   4001 C CG  . TYR A 1 557 ? 4.407   -25.594 12.250  1.00 86.61  ? 557 TYR A CG  1 
ATOM   4002 C CD1 . TYR A 1 557 ? 4.052   -24.246 12.125  1.00 83.28  ? 557 TYR A CD1 1 
ATOM   4003 C CD2 . TYR A 1 557 ? 4.432   -26.370 11.085  1.00 84.27  ? 557 TYR A CD2 1 
ATOM   4004 C CE1 . TYR A 1 557 ? 3.695   -23.699 10.890  1.00 82.28  ? 557 TYR A CE1 1 
ATOM   4005 C CE2 . TYR A 1 557 ? 4.087   -25.831 9.842   1.00 79.89  ? 557 TYR A CE2 1 
ATOM   4006 C CZ  . TYR A 1 557 ? 3.709   -24.495 9.749   1.00 90.19  ? 557 TYR A CZ  1 
ATOM   4007 O OH  . TYR A 1 557 ? 3.355   -23.946 8.519   1.00 89.99  ? 557 TYR A OH  1 
ATOM   4008 N N   . SER A 1 558 ? 2.550   -25.250 16.130  1.00 86.25  ? 558 SER A N   1 
ATOM   4009 C CA  . SER A 1 558 ? 1.416   -24.424 16.549  1.00 89.48  ? 558 SER A CA  1 
ATOM   4010 C C   . SER A 1 558 ? 1.252   -23.231 15.607  1.00 88.36  ? 558 SER A C   1 
ATOM   4011 O O   . SER A 1 558 ? 1.779   -22.138 15.845  1.00 86.54  ? 558 SER A O   1 
ATOM   4012 C CB  . SER A 1 558 ? 1.536   -23.958 18.014  1.00 84.77  ? 558 SER A CB  1 
ATOM   4013 O OG  . SER A 1 558 ? 2.863   -23.690 18.437  1.00 76.04  ? 558 SER A OG  1 
ATOM   4014 N N   . GLN A 1 559 ? 0.547   -23.484 14.504  1.00 84.01  ? 559 GLN A N   1 
ATOM   4015 C CA  . GLN A 1 559 ? 0.220   -22.505 13.476  1.00 71.34  ? 559 GLN A CA  1 
ATOM   4016 C C   . GLN A 1 559 ? -0.917  -21.644 13.998  1.00 63.95  ? 559 GLN A C   1 
ATOM   4017 O O   . GLN A 1 559 ? -2.033  -22.138 14.169  1.00 64.45  ? 559 GLN A O   1 
ATOM   4018 C CB  . GLN A 1 559 ? -0.190  -23.247 12.204  1.00 75.36  ? 559 GLN A CB  1 
ATOM   4019 C CG  . GLN A 1 559 ? -0.874  -22.413 11.147  1.00 61.05  ? 559 GLN A CG  1 
ATOM   4020 C CD  . GLN A 1 559 ? 0.022   -21.364 10.571  1.00 58.28  ? 559 GLN A CD  1 
ATOM   4021 O OE1 . GLN A 1 559 ? 0.091   -20.251 11.085  1.00 61.12  ? 559 GLN A OE1 1 
ATOM   4022 N NE2 . GLN A 1 559 ? 0.675   -21.688 9.456   1.00 50.14  ? 559 GLN A NE2 1 
ATOM   4023 N N   . LYS A 1 560 ? -0.647  -20.372 14.276  1.00 62.87  ? 560 LYS A N   1 
ATOM   4024 C CA  . LYS A 1 560 ? -1.701  -19.509 14.789  1.00 57.41  ? 560 LYS A CA  1 
ATOM   4025 C C   . LYS A 1 560 ? -2.623  -19.035 13.658  1.00 56.72  ? 560 LYS A C   1 
ATOM   4026 O O   . LYS A 1 560 ? -2.216  -18.907 12.497  1.00 58.15  ? 560 LYS A O   1 
ATOM   4027 C CB  . LYS A 1 560 ? -1.120  -18.314 15.563  1.00 59.95  ? 560 LYS A CB  1 
ATOM   4028 C CG  . LYS A 1 560 ? -1.114  -18.496 17.102  1.00 58.03  ? 560 LYS A CG  1 
ATOM   4029 C CD  . LYS A 1 560 ? -0.009  -17.709 17.808  1.00 60.50  ? 560 LYS A CD  1 
ATOM   4030 C CE  . LYS A 1 560 ? -0.472  -16.295 18.188  1.00 63.68  ? 560 LYS A CE  1 
ATOM   4031 N NZ  . LYS A 1 560 ? -0.985  -16.192 19.592  1.00 58.30  ? 560 LYS A NZ  1 
ATOM   4032 N N   . TYR A 1 561 ? -3.885  -18.784 14.015  1.00 44.54  ? 561 TYR A N   1 
ATOM   4033 C CA  . TYR A 1 561 ? -4.933  -18.425 13.078  1.00 39.71  ? 561 TYR A CA  1 
ATOM   4034 C C   . TYR A 1 561 ? -5.733  -17.258 13.642  1.00 43.27  ? 561 TYR A C   1 
ATOM   4035 O O   . TYR A 1 561 ? -5.802  -17.073 14.863  1.00 42.13  ? 561 TYR A O   1 
ATOM   4036 C CB  . TYR A 1 561 ? -5.873  -19.600 12.855  1.00 42.86  ? 561 TYR A CB  1 
ATOM   4037 C CG  . TYR A 1 561 ? -5.303  -20.763 12.095  1.00 44.76  ? 561 TYR A CG  1 
ATOM   4038 C CD1 . TYR A 1 561 ? -5.219  -20.742 10.721  1.00 44.56  ? 561 TYR A CD1 1 
ATOM   4039 C CD2 . TYR A 1 561 ? -4.841  -21.890 12.763  1.00 48.66  ? 561 TYR A CD2 1 
ATOM   4040 C CE1 . TYR A 1 561 ? -4.708  -21.821 10.021  1.00 51.02  ? 561 TYR A CE1 1 
ATOM   4041 C CE2 . TYR A 1 561 ? -4.319  -22.967 12.077  1.00 49.47  ? 561 TYR A CE2 1 
ATOM   4042 C CZ  . TYR A 1 561 ? -4.254  -22.931 10.703  1.00 50.62  ? 561 TYR A CZ  1 
ATOM   4043 O OH  . TYR A 1 561 ? -3.732  -23.995 9.992   1.00 49.64  ? 561 TYR A OH  1 
ATOM   4044 N N   . ARG A 1 562 ? -6.336  -16.467 12.740  1.00 38.70  ? 562 ARG A N   1 
ATOM   4045 C CA  . ARG A 1 562 ? -7.392  -15.520 13.076  1.00 38.02  ? 562 ARG A CA  1 
ATOM   4046 C C   . ARG A 1 562 ? -8.671  -15.977 12.378  1.00 38.45  ? 562 ARG A C   1 
ATOM   4047 O O   . ARG A 1 562 ? -8.628  -16.550 11.280  1.00 32.23  ? 562 ARG A O   1 
ATOM   4048 C CB  . ARG A 1 562 ? -7.042  -14.072 12.650  1.00 39.40  ? 562 ARG A CB  1 
ATOM   4049 C CG  . ARG A 1 562 ? -5.884  -13.483 13.405  1.00 54.01  ? 562 ARG A CG  1 
ATOM   4050 C CD  . ARG A 1 562 ? -6.316  -12.747 14.671  1.00 68.57  ? 562 ARG A CD  1 
ATOM   4051 N NE  . ARG A 1 562 ? -7.239  -11.625 14.477  1.00 76.87  ? 562 ARG A NE  1 
ATOM   4052 C CZ  . ARG A 1 562 ? -6.852  -10.397 14.125  1.00 87.22  ? 562 ARG A CZ  1 
ATOM   4053 N NH1 . ARG A 1 562 ? -5.557  -10.140 13.959  1.00 90.79  ? 562 ARG A NH1 1 
ATOM   4054 N NH2 . ARG A 1 562 ? -7.750  -9.412  13.980  1.00 83.97  ? 562 ARG A NH2 1 
ATOM   4055 N N   . ALA A 1 563 ? -9.817  -15.725 13.001  1.00 33.01  ? 563 ALA A N   1 
ATOM   4056 C CA  . ALA A 1 563 ? -11.083 -16.154 12.429  1.00 30.87  ? 563 ALA A CA  1 
ATOM   4057 C C   . ALA A 1 563 ? -11.940 -14.970 11.999  1.00 35.21  ? 563 ALA A C   1 
ATOM   4058 O O   . ALA A 1 563 ? -11.967 -13.926 12.662  1.00 35.73  ? 563 ALA A O   1 
ATOM   4059 C CB  . ALA A 1 563 ? -11.863 -17.010 13.425  1.00 33.07  ? 563 ALA A CB  1 
ATOM   4060 N N   . ARG A 1 564 ? -12.644 -15.135 10.887  1.00 34.17  ? 564 ARG A N   1 
ATOM   4061 C CA  . ARG A 1 564 ? -13.734 -14.241 10.547  1.00 34.87  ? 564 ARG A CA  1 
ATOM   4062 C C   . ARG A 1 564 ? -14.973 -15.095 10.346  1.00 35.27  ? 564 ARG A C   1 
ATOM   4063 O O   . ARG A 1 564 ? -14.884 -16.309 10.159  1.00 36.55  ? 564 ARG A O   1 
ATOM   4064 C CB  . ARG A 1 564 ? -13.498 -13.461 9.273   1.00 33.05  ? 564 ARG A CB  1 
ATOM   4065 C CG  . ARG A 1 564 ? -12.145 -12.932 9.069   1.00 27.82  ? 564 ARG A CG  1 
ATOM   4066 C CD  . ARG A 1 564 ? -11.987 -13.049 7.585   1.00 31.42  ? 564 ARG A CD  1 
ATOM   4067 N NE  . ARG A 1 564 ? -11.295 -11.947 6.945   1.00 31.93  ? 564 ARG A NE  1 
ATOM   4068 C CZ  . ARG A 1 564 ? -11.052 -11.919 5.641   1.00 31.93  ? 564 ARG A CZ  1 
ATOM   4069 N NH1 . ARG A 1 564 ? -11.466 -12.898 4.848   1.00 28.19  ? 564 ARG A NH1 1 
ATOM   4070 N NH2 . ARG A 1 564 ? -10.408 -10.901 5.123   1.00 39.47  ? 564 ARG A NH2 1 
ATOM   4071 N N   . ILE A 1 565 ? -16.131 -14.455 10.353  1.00 29.52  ? 565 ILE A N   1 
ATOM   4072 C CA  . ILE A 1 565 ? -17.381 -15.176 10.215  1.00 29.07  ? 565 ILE A CA  1 
ATOM   4073 C C   . ILE A 1 565 ? -18.309 -14.325 9.375   1.00 29.38  ? 565 ILE A C   1 
ATOM   4074 O O   . ILE A 1 565 ? -18.288 -13.094 9.464   1.00 30.46  ? 565 ILE A O   1 
ATOM   4075 C CB  . ILE A 1 565 ? -17.987 -15.526 11.590  1.00 32.72  ? 565 ILE A CB  1 
ATOM   4076 C CG1 . ILE A 1 565 ? -19.298 -16.280 11.408  1.00 34.58  ? 565 ILE A CG1 1 
ATOM   4077 C CG2 . ILE A 1 565 ? -18.176 -14.291 12.459  1.00 29.57  ? 565 ILE A CG2 1 
ATOM   4078 C CD1 . ILE A 1 565 ? -19.821 -16.885 12.691  1.00 38.66  ? 565 ILE A CD1 1 
ATOM   4079 N N   . HIS A 1 566 ? -19.089 -14.988 8.530   1.00 29.25  ? 566 HIS A N   1 
ATOM   4080 C CA  . HIS A 1 566 ? -19.942 -14.380 7.513   1.00 27.52  ? 566 HIS A CA  1 
ATOM   4081 C C   . HIS A 1 566 ? -21.353 -14.737 7.968   1.00 29.21  ? 566 HIS A C   1 
ATOM   4082 O O   . HIS A 1 566 ? -21.758 -15.903 7.912   1.00 33.42  ? 566 HIS A O   1 
ATOM   4083 C CB  . HIS A 1 566 ? -19.561 -14.924 6.128   1.00 24.81  ? 566 HIS A CB  1 
ATOM   4084 C CG  . HIS A 1 566 ? -20.188 -14.215 4.963   1.00 34.85  ? 566 HIS A CG  1 
ATOM   4085 N ND1 . HIS A 1 566 ? -20.792 -14.890 3.920   1.00 36.36  ? 566 HIS A ND1 1 
ATOM   4086 C CD2 . HIS A 1 566 ? -20.268 -12.897 4.647   1.00 40.29  ? 566 HIS A CD2 1 
ATOM   4087 C CE1 . HIS A 1 566 ? -21.234 -14.020 3.026   1.00 35.72  ? 566 HIS A CE1 1 
ATOM   4088 N NE2 . HIS A 1 566 ? -20.931 -12.802 3.442   1.00 37.06  ? 566 HIS A NE2 1 
ATOM   4089 N N   . TYR A 1 567 ? -22.074 -13.749 8.496   1.00 29.49  ? 567 TYR A N   1 
ATOM   4090 C CA  . TYR A 1 567 ? -23.368 -13.958 9.143   1.00 28.92  ? 567 TYR A CA  1 
ATOM   4091 C C   . TYR A 1 567 ? -24.337 -12.867 8.724   1.00 28.63  ? 567 TYR A C   1 
ATOM   4092 O O   . TYR A 1 567 ? -23.988 -11.930 8.005   1.00 34.74  ? 567 TYR A O   1 
ATOM   4093 C CB  . TYR A 1 567 ? -23.257 -13.938 10.668  1.00 30.93  ? 567 TYR A CB  1 
ATOM   4094 C CG  . TYR A 1 567 ? -23.022 -12.551 11.191  1.00 24.69  ? 567 TYR A CG  1 
ATOM   4095 C CD1 . TYR A 1 567 ? -21.782 -11.968 11.085  1.00 27.34  ? 567 TYR A CD1 1 
ATOM   4096 C CD2 . TYR A 1 567 ? -24.045 -11.816 11.739  1.00 29.81  ? 567 TYR A CD2 1 
ATOM   4097 C CE1 . TYR A 1 567 ? -21.544 -10.703 11.525  1.00 32.55  ? 567 TYR A CE1 1 
ATOM   4098 C CE2 . TYR A 1 567 ? -23.834 -10.535 12.180  1.00 35.45  ? 567 TYR A CE2 1 
ATOM   4099 C CZ  . TYR A 1 567 ? -22.571 -9.976  12.074  1.00 38.22  ? 567 TYR A CZ  1 
ATOM   4100 O OH  . TYR A 1 567 ? -22.338 -8.687  12.517  1.00 39.29  ? 567 TYR A OH  1 
ATOM   4101 N N   . ALA A 1 568 ? -25.564 -12.978 9.203   1.00 29.29  ? 568 ALA A N   1 
ATOM   4102 C CA  . ALA A 1 568 ? -26.527 -11.893 9.080   1.00 30.95  ? 568 ALA A CA  1 
ATOM   4103 C C   . ALA A 1 568 ? -27.430 -11.977 10.293  1.00 33.75  ? 568 ALA A C   1 
ATOM   4104 O O   . ALA A 1 568 ? -27.995 -13.039 10.567  1.00 38.52  ? 568 ALA A O   1 
ATOM   4105 C CB  . ALA A 1 568 ? -27.321 -11.999 7.789   1.00 33.84  ? 568 ALA A CB  1 
ATOM   4106 N N   . SER A 1 569 ? -27.523 -10.898 11.050  1.00 32.87  ? 569 SER A N   1 
ATOM   4107 C CA  . SER A 1 569 ? -28.240 -10.923 12.311  1.00 39.07  ? 569 SER A CA  1 
ATOM   4108 C C   . SER A 1 569 ? -29.338 -9.878  12.310  1.00 39.04  ? 569 SER A C   1 
ATOM   4109 O O   . SER A 1 569 ? -29.180 -8.798  11.743  1.00 43.52  ? 569 SER A O   1 
ATOM   4110 C CB  . SER A 1 569 ? -27.298 -10.671 13.488  1.00 42.38  ? 569 SER A CB  1 
ATOM   4111 O OG  . SER A 1 569 ? -27.989 -10.821 14.722  1.00 41.92  ? 569 SER A OG  1 
ATOM   4112 N N   . THR A 1 570 ? -30.445 -10.187 12.978  1.00 41.33  ? 570 THR A N   1 
ATOM   4113 C CA  . THR A 1 570 ? -31.457 -9.157  13.180  1.00 45.05  ? 570 THR A CA  1 
ATOM   4114 C C   . THR A 1 570 ? -31.164 -8.275  14.385  1.00 48.80  ? 570 THR A C   1 
ATOM   4115 O O   . THR A 1 570 ? -31.708 -7.171  14.472  1.00 50.79  ? 570 THR A O   1 
ATOM   4116 C CB  . THR A 1 570 ? -32.833 -9.779  13.345  1.00 44.71  ? 570 THR A CB  1 
ATOM   4117 O OG1 . THR A 1 570 ? -32.792 -10.686 14.444  1.00 48.50  ? 570 THR A OG1 1 
ATOM   4118 C CG2 . THR A 1 570 ? -33.233 -10.529 12.098  1.00 43.06  ? 570 THR A CG2 1 
ATOM   4119 N N   . SER A 1 571 ? -30.315 -8.718  15.306  1.00 46.13  ? 571 SER A N   1 
ATOM   4120 C CA  . SER A 1 571 ? -29.946 -7.888  16.439  1.00 47.45  ? 571 SER A CA  1 
ATOM   4121 C C   . SER A 1 571 ? -28.460 -8.058  16.704  1.00 50.56  ? 571 SER A C   1 
ATOM   4122 O O   . SER A 1 571 ? -27.812 -8.954  16.151  1.00 49.04  ? 571 SER A O   1 
ATOM   4123 C CB  . SER A 1 571 ? -30.782 -8.240  17.674  1.00 53.66  ? 571 SER A CB  1 
ATOM   4124 O OG  . SER A 1 571 ? -30.430 -9.518  18.185  1.00 48.62  ? 571 SER A OG  1 
ATOM   4125 N N   . GLN A 1 572 ? -27.911 -7.183  17.557  1.00 53.86  ? 572 GLN A N   1 
ATOM   4126 C CA  . GLN A 1 572 ? -26.509 -7.324  17.939  1.00 51.14  ? 572 GLN A CA  1 
ATOM   4127 C C   . GLN A 1 572 ? -26.356 -8.603  18.745  1.00 47.41  ? 572 GLN A C   1 
ATOM   4128 O O   . GLN A 1 572 ? -27.253 -8.982  19.500  1.00 49.06  ? 572 GLN A O   1 
ATOM   4129 C CB  . GLN A 1 572 ? -26.034 -6.123  18.751  1.00 57.42  ? 572 GLN A CB  1 
ATOM   4130 C CG  . GLN A 1 572 ? -26.455 -4.776  18.185  1.00 65.16  ? 572 GLN A CG  1 
ATOM   4131 C CD  . GLN A 1 572 ? -25.406 -3.676  18.379  1.00 77.84  ? 572 GLN A CD  1 
ATOM   4132 O OE1 . GLN A 1 572 ? -24.554 -3.465  17.507  1.00 76.24  ? 572 GLN A OE1 1 
ATOM   4133 N NE2 . GLN A 1 572 ? -25.431 -3.010  19.538  1.00 74.87  ? 572 GLN A NE2 1 
ATOM   4134 N N   . ILE A 1 573 ? -25.234 -9.292  18.568  1.00 47.62  ? 573 ILE A N   1 
ATOM   4135 C CA  . ILE A 1 573 ? -25.079 -10.647 19.087  1.00 40.87  ? 573 ILE A CA  1 
ATOM   4136 C C   . ILE A 1 573 ? -23.618 -10.928 19.421  1.00 40.91  ? 573 ILE A C   1 
ATOM   4137 O O   . ILE A 1 573 ? -22.710 -10.186 19.035  1.00 40.47  ? 573 ILE A O   1 
ATOM   4138 C CB  . ILE A 1 573 ? -25.610 -11.705 18.097  1.00 48.93  ? 573 ILE A CB  1 
ATOM   4139 C CG1 . ILE A 1 573 ? -25.103 -11.430 16.681  1.00 46.58  ? 573 ILE A CG1 1 
ATOM   4140 C CG2 . ILE A 1 573 ? -27.133 -11.807 18.148  1.00 42.27  ? 573 ILE A CG2 1 
ATOM   4141 C CD1 . ILE A 1 573 ? -25.177 -12.646 15.801  1.00 44.47  ? 573 ILE A CD1 1 
ATOM   4142 N N   . THR A 1 574 ? -23.406 -12.003 20.181  1.00 35.26  ? 574 THR A N   1 
ATOM   4143 C CA  . THR A 1 574 ? -22.087 -12.468 20.592  1.00 41.45  ? 574 THR A CA  1 
ATOM   4144 C C   . THR A 1 574 ? -21.864 -13.883 20.076  1.00 51.53  ? 574 THR A C   1 
ATOM   4145 O O   . THR A 1 574 ? -22.606 -14.812 20.432  1.00 55.12  ? 574 THR A O   1 
ATOM   4146 C CB  . THR A 1 574 ? -21.912 -12.446 22.111  1.00 40.80  ? 574 THR A CB  1 
ATOM   4147 O OG1 . THR A 1 574 ? -21.830 -11.095 22.574  1.00 51.38  ? 574 THR A OG1 1 
ATOM   4148 C CG2 . THR A 1 574 ? -20.652 -13.204 22.515  1.00 38.59  ? 574 THR A CG2 1 
ATOM   4149 N N   . PHE A 1 575 ? -20.834 -14.041 19.252  1.00 43.97  ? 575 PHE A N   1 
ATOM   4150 C CA  . PHE A 1 575 ? -20.407 -15.342 18.782  1.00 37.28  ? 575 PHE A CA  1 
ATOM   4151 C C   . PHE A 1 575 ? -19.303 -15.887 19.673  1.00 43.31  ? 575 PHE A C   1 
ATOM   4152 O O   . PHE A 1 575 ? -18.366 -15.157 20.020  1.00 46.61  ? 575 PHE A O   1 
ATOM   4153 C CB  . PHE A 1 575 ? -19.938 -15.236 17.335  1.00 37.26  ? 575 PHE A CB  1 
ATOM   4154 C CG  . PHE A 1 575 ? -21.054 -15.144 16.356  1.00 37.06  ? 575 PHE A CG  1 
ATOM   4155 C CD1 . PHE A 1 575 ? -22.098 -16.062 16.411  1.00 45.15  ? 575 PHE A CD1 1 
ATOM   4156 C CD2 . PHE A 1 575 ? -21.059 -14.194 15.374  1.00 32.83  ? 575 PHE A CD2 1 
ATOM   4157 C CE1 . PHE A 1 575 ? -23.146 -16.019 15.515  1.00 41.62  ? 575 PHE A CE1 1 
ATOM   4158 C CE2 . PHE A 1 575 ? -22.090 -14.141 14.471  1.00 37.74  ? 575 PHE A CE2 1 
ATOM   4159 C CZ  . PHE A 1 575 ? -23.141 -15.058 14.538  1.00 40.79  ? 575 PHE A CZ  1 
ATOM   4160 N N   . THR A 1 576 ? -19.419 -17.163 20.059  1.00 45.51  ? 576 THR A N   1 
ATOM   4161 C CA  . THR A 1 576 ? -18.358 -17.858 20.784  1.00 42.46  ? 576 THR A CA  1 
ATOM   4162 C C   . THR A 1 576 ? -17.834 -19.017 19.951  1.00 46.72  ? 576 THR A C   1 
ATOM   4163 O O   . THR A 1 576 ? -18.606 -19.906 19.563  1.00 48.99  ? 576 THR A O   1 
ATOM   4164 C CB  . THR A 1 576 ? -18.836 -18.371 22.144  1.00 36.71  ? 576 THR A CB  1 
ATOM   4165 O OG1 . THR A 1 576 ? -19.008 -17.271 23.044  1.00 35.65  ? 576 THR A OG1 1 
ATOM   4166 C CG2 . THR A 1 576 ? -17.805 -19.324 22.728  1.00 38.76  ? 576 THR A CG2 1 
ATOM   4167 N N   . LEU A 1 577 ? -16.527 -19.017 19.695  1.00 42.62  ? 577 LEU A N   1 
ATOM   4168 C CA  . LEU A 1 577 ? -15.861 -20.172 19.109  1.00 42.60  ? 577 LEU A CA  1 
ATOM   4169 C C   . LEU A 1 577 ? -15.229 -21.004 20.215  1.00 43.80  ? 577 LEU A C   1 
ATOM   4170 O O   . LEU A 1 577 ? -14.653 -20.448 21.162  1.00 43.03  ? 577 LEU A O   1 
ATOM   4171 C CB  . LEU A 1 577 ? -14.788 -19.749 18.101  1.00 43.26  ? 577 LEU A CB  1 
ATOM   4172 C CG  . LEU A 1 577 ? -15.282 -18.921 16.905  1.00 41.03  ? 577 LEU A CG  1 
ATOM   4173 C CD1 . LEU A 1 577 ? -14.130 -18.550 16.034  1.00 35.17  ? 577 LEU A CD1 1 
ATOM   4174 C CD2 . LEU A 1 577 ? -16.366 -19.625 16.101  1.00 42.95  ? 577 LEU A CD2 1 
ATOM   4175 N N   . SER A 1 578 ? -15.356 -22.337 20.094  1.00 43.99  ? 578 SER A N   1 
ATOM   4176 C CA  . SER A 1 578 ? -14.721 -23.303 20.995  1.00 42.08  ? 578 SER A CA  1 
ATOM   4177 C C   . SER A 1 578 ? -14.096 -24.456 20.210  1.00 44.36  ? 578 SER A C   1 
ATOM   4178 O O   . SER A 1 578 ? -14.442 -24.719 19.058  1.00 45.90  ? 578 SER A O   1 
ATOM   4179 C CB  . SER A 1 578 ? -15.713 -23.890 21.992  1.00 40.34  ? 578 SER A CB  1 
ATOM   4180 O OG  . SER A 1 578 ? -16.381 -22.870 22.682  1.00 43.93  ? 578 SER A OG  1 
ATOM   4181 N N   . LEU A 1 579 ? -13.179 -25.157 20.872  1.00 46.31  ? 579 LEU A N   1 
ATOM   4182 C CA  . LEU A 1 579 ? -12.508 -26.338 20.340  1.00 41.85  ? 579 LEU A CA  1 
ATOM   4183 C C   . LEU A 1 579 ? -12.486 -27.392 21.435  1.00 47.47  ? 579 LEU A C   1 
ATOM   4184 O O   . LEU A 1 579 ? -11.908 -27.157 22.503  1.00 49.58  ? 579 LEU A O   1 
ATOM   4185 C CB  . LEU A 1 579 ? -11.076 -26.030 19.915  1.00 42.71  ? 579 LEU A CB  1 
ATOM   4186 C CG  . LEU A 1 579 ? -10.729 -25.856 18.443  1.00 44.59  ? 579 LEU A CG  1 
ATOM   4187 C CD1 . LEU A 1 579 ? -9.215  -25.834 18.273  1.00 46.26  ? 579 LEU A CD1 1 
ATOM   4188 C CD2 . LEU A 1 579 ? -11.338 -26.944 17.609  1.00 46.94  ? 579 LEU A CD2 1 
ATOM   4189 N N   . ASP A 1 580 ? -13.102 -28.554 21.167  1.00 52.51  ? 580 ASP A N   1 
ATOM   4190 C CA  . ASP A 1 580 ? -13.252 -29.637 22.159  1.00 49.81  ? 580 ASP A CA  1 
ATOM   4191 C C   . ASP A 1 580 ? -13.921 -29.143 23.443  1.00 51.66  ? 580 ASP A C   1 
ATOM   4192 O O   . ASP A 1 580 ? -13.718 -29.708 24.520  1.00 49.29  ? 580 ASP A O   1 
ATOM   4193 C CB  . ASP A 1 580 ? -11.908 -30.298 22.460  1.00 44.92  ? 580 ASP A CB  1 
ATOM   4194 C CG  . ASP A 1 580 ? -11.224 -30.803 21.202  1.00 52.77  ? 580 ASP A CG  1 
ATOM   4195 O OD1 . ASP A 1 580 ? -11.921 -30.876 20.162  1.00 49.98  ? 580 ASP A OD1 1 
ATOM   4196 O OD2 . ASP A 1 580 ? -10.005 -31.114 21.248  1.00 49.99  ? 580 ASP A OD2 1 
ATOM   4197 N N   . GLY A 1 581 ? -14.729 -28.077 23.327  1.00 45.22  ? 581 GLY A N   1 
ATOM   4198 C CA  . GLY A 1 581 ? -15.494 -27.536 24.422  1.00 43.09  ? 581 GLY A CA  1 
ATOM   4199 C C   . GLY A 1 581 ? -14.825 -26.379 25.122  1.00 46.65  ? 581 GLY A C   1 
ATOM   4200 O O   . GLY A 1 581 ? -15.514 -25.597 25.804  1.00 43.09  ? 581 GLY A O   1 
ATOM   4201 N N   . ALA A 1 582 ? -13.505 -26.265 24.982  1.00 42.30  ? 582 ALA A N   1 
ATOM   4202 C CA  . ALA A 1 582 ? -12.758 -25.127 25.495  1.00 41.00  ? 582 ALA A CA  1 
ATOM   4203 C C   . ALA A 1 582 ? -13.068 -23.886 24.660  1.00 45.37  ? 582 ALA A C   1 
ATOM   4204 O O   . ALA A 1 582 ? -12.834 -23.900 23.447  1.00 48.91  ? 582 ALA A O   1 
ATOM   4205 C CB  . ALA A 1 582 ? -11.271 -25.456 25.455  1.00 36.51  ? 582 ALA A CB  1 
ATOM   4206 N N   . PRO A 1 583 ? -13.611 -22.810 25.233  1.00 40.30  ? 583 PRO A N   1 
ATOM   4207 C CA  . PRO A 1 583 ? -13.885 -21.613 24.427  1.00 39.75  ? 583 PRO A CA  1 
ATOM   4208 C C   . PRO A 1 583 ? -12.603 -20.823 24.231  1.00 44.20  ? 583 PRO A C   1 
ATOM   4209 O O   . PRO A 1 583 ? -11.864 -20.603 25.192  1.00 49.46  ? 583 PRO A O   1 
ATOM   4210 C CB  . PRO A 1 583 ? -14.888 -20.828 25.280  1.00 43.15  ? 583 PRO A CB  1 
ATOM   4211 C CG  . PRO A 1 583 ? -15.357 -21.768 26.331  1.00 43.00  ? 583 PRO A CG  1 
ATOM   4212 C CD  . PRO A 1 583 ? -14.173 -22.670 26.578  1.00 49.58  ? 583 PRO A CD  1 
ATOM   4213 N N   . PHE A 1 584 ? -12.349 -20.379 22.985  1.00 44.49  ? 584 PHE A N   1 
ATOM   4214 C CA  . PHE A 1 584 ? -11.082 -19.745 22.623  1.00 36.32  ? 584 PHE A CA  1 
ATOM   4215 C C   . PHE A 1 584 ? -11.199 -18.440 21.850  1.00 37.36  ? 584 PHE A C   1 
ATOM   4216 O O   . PHE A 1 584 ? -10.175 -17.909 21.437  1.00 38.68  ? 584 PHE A O   1 
ATOM   4217 C CB  . PHE A 1 584 ? -10.233 -20.711 21.795  1.00 36.40  ? 584 PHE A CB  1 
ATOM   4218 C CG  . PHE A 1 584 ? -10.704 -20.876 20.377  1.00 41.02  ? 584 PHE A CG  1 
ATOM   4219 C CD1 . PHE A 1 584 ? -11.676 -21.818 20.077  1.00 40.28  ? 584 PHE A CD1 1 
ATOM   4220 C CD2 . PHE A 1 584 ? -10.168 -20.109 19.332  1.00 43.54  ? 584 PHE A CD2 1 
ATOM   4221 C CE1 . PHE A 1 584 ? -12.119 -21.997 18.767  1.00 43.53  ? 584 PHE A CE1 1 
ATOM   4222 C CE2 . PHE A 1 584 ? -10.612 -20.282 18.013  1.00 39.74  ? 584 PHE A CE2 1 
ATOM   4223 C CZ  . PHE A 1 584 ? -11.586 -21.227 17.735  1.00 42.10  ? 584 PHE A CZ  1 
ATOM   4224 N N   . ASN A 1 585 ? -12.405 -17.934 21.613  1.00 43.76  ? 585 ASN A N   1 
ATOM   4225 C CA  . ASN A 1 585 ? -12.634 -16.690 20.889  1.00 39.35  ? 585 ASN A CA  1 
ATOM   4226 C C   . ASN A 1 585 ? -14.057 -16.222 21.138  1.00 40.07  ? 585 ASN A C   1 
ATOM   4227 O O   . ASN A 1 585 ? -15.009 -16.999 20.991  1.00 38.82  ? 585 ASN A O   1 
ATOM   4228 C CB  . ASN A 1 585 ? -12.410 -16.849 19.384  1.00 37.22  ? 585 ASN A CB  1 
ATOM   4229 C CG  . ASN A 1 585 ? -11.245 -16.042 18.892  1.00 46.00  ? 585 ASN A CG  1 
ATOM   4230 O OD1 . ASN A 1 585 ? -10.789 -15.118 19.576  1.00 53.91  ? 585 ASN A OD1 1 
ATOM   4231 N ND2 . ASN A 1 585 ? -10.786 -16.333 17.682  1.00 45.20  ? 585 ASN A ND2 1 
ATOM   4232 N N   . GLN A 1 586 ? -14.199 -14.953 21.488  1.00 39.24  ? 586 GLN A N   1 
ATOM   4233 C CA  . GLN A 1 586 ? -15.510 -14.347 21.621  1.00 39.19  ? 586 GLN A CA  1 
ATOM   4234 C C   . GLN A 1 586 ? -15.409 -12.893 21.170  1.00 46.77  ? 586 GLN A C   1 
ATOM   4235 O O   . GLN A 1 586 ? -14.309 -12.334 21.076  1.00 54.29  ? 586 GLN A O   1 
ATOM   4236 C CB  . GLN A 1 586 ? -16.007 -14.504 23.059  1.00 41.66  ? 586 GLN A CB  1 
ATOM   4237 C CG  . GLN A 1 586 ? -17.412 -14.024 23.325  1.00 43.40  ? 586 GLN A CG  1 
ATOM   4238 C CD  . GLN A 1 586 ? -17.850 -14.269 24.762  1.00 41.79  ? 586 GLN A CD  1 
ATOM   4239 O OE1 . GLN A 1 586 ? -17.304 -13.687 25.711  1.00 45.40  ? 586 GLN A OE1 1 
ATOM   4240 N NE2 . GLN A 1 586 ? -18.860 -15.104 24.924  1.00 39.08  ? 586 GLN A NE2 1 
ATOM   4241 N N   . TYR A 1 587 ? -16.559 -12.309 20.823  1.00 43.24  ? 587 TYR A N   1 
ATOM   4242 C CA  . TYR A 1 587 ? -16.656 -10.907 20.414  1.00 44.82  ? 587 TYR A CA  1 
ATOM   4243 C C   . TYR A 1 587 ? -18.111 -10.540 20.095  1.00 47.46  ? 587 TYR A C   1 
ATOM   4244 O O   . TYR A 1 587 ? -18.959 -11.410 19.837  1.00 38.79  ? 587 TYR A O   1 
ATOM   4245 C CB  . TYR A 1 587 ? -15.780 -10.618 19.206  1.00 46.49  ? 587 TYR A CB  1 
ATOM   4246 C CG  . TYR A 1 587 ? -15.265 -9.203  19.105  1.00 50.96  ? 587 TYR A CG  1 
ATOM   4247 C CD1 . TYR A 1 587 ? -14.456 -8.659  20.091  1.00 49.03  ? 587 TYR A CD1 1 
ATOM   4248 C CD2 . TYR A 1 587 ? -15.586 -8.413  18.002  1.00 53.61  ? 587 TYR A CD2 1 
ATOM   4249 C CE1 . TYR A 1 587 ? -13.975 -7.363  19.981  1.00 60.49  ? 587 TYR A CE1 1 
ATOM   4250 C CE2 . TYR A 1 587 ? -15.115 -7.122  17.879  1.00 58.19  ? 587 TYR A CE2 1 
ATOM   4251 C CZ  . TYR A 1 587 ? -14.309 -6.596  18.868  1.00 63.16  ? 587 TYR A CZ  1 
ATOM   4252 O OH  . TYR A 1 587 ? -13.853 -5.298  18.726  1.00 65.47  ? 587 TYR A OH  1 
ATOM   4253 N N   . TYR A 1 588 ? -18.378 -9.226  20.118  1.00 46.88  ? 588 TYR A N   1 
ATOM   4254 C CA  . TYR A 1 588 ? -19.667 -8.641  19.776  1.00 48.96  ? 588 TYR A CA  1 
ATOM   4255 C C   . TYR A 1 588 ? -19.733 -8.362  18.280  1.00 49.78  ? 588 TYR A C   1 
ATOM   4256 O O   . TYR A 1 588 ? -18.719 -8.066  17.643  1.00 50.75  ? 588 TYR A O   1 
ATOM   4257 C CB  . TYR A 1 588 ? -19.877 -7.358  20.576  1.00 60.88  ? 588 TYR A CB  1 
ATOM   4258 C CG  . TYR A 1 588 ? -21.318 -7.053  20.975  1.00 83.59  ? 588 TYR A CG  1 
ATOM   4259 C CD1 . TYR A 1 588 ? -21.916 -7.684  22.064  1.00 98.14  ? 588 TYR A CD1 1 
ATOM   4260 C CD2 . TYR A 1 588 ? -22.053 -6.067  20.315  1.00 87.84  ? 588 TYR A CD2 1 
ATOM   4261 C CE1 . TYR A 1 588 ? -23.223 -7.387  22.444  1.00 97.39  ? 588 TYR A CE1 1 
ATOM   4262 C CE2 . TYR A 1 588 ? -23.359 -5.760  20.698  1.00 91.71  ? 588 TYR A CE2 1 
ATOM   4263 C CZ  . TYR A 1 588 ? -23.937 -6.425  21.760  1.00 100.02 ? 588 TYR A CZ  1 
ATOM   4264 O OH  . TYR A 1 588 ? -25.226 -6.131  22.144  1.00 96.54  ? 588 TYR A OH  1 
ATOM   4265 N N   . PHE A 1 589 ? -20.931 -8.480  17.711  1.00 44.39  ? 589 PHE A N   1 
ATOM   4266 C CA  . PHE A 1 589 ? -21.093 -8.352  16.267  1.00 45.01  ? 589 PHE A CA  1 
ATOM   4267 C C   . PHE A 1 589 ? -22.328 -7.505  15.962  1.00 51.71  ? 589 PHE A C   1 
ATOM   4268 O O   . PHE A 1 589 ? -23.302 -7.494  16.720  1.00 56.32  ? 589 PHE A O   1 
ATOM   4269 C CB  . PHE A 1 589 ? -21.153 -9.747  15.604  1.00 38.92  ? 589 PHE A CB  1 
ATOM   4270 C CG  . PHE A 1 589 ? -19.806 -10.468 15.569  1.00 38.60  ? 589 PHE A CG  1 
ATOM   4271 C CD1 . PHE A 1 589 ? -19.357 -11.205 16.653  1.00 35.01  ? 589 PHE A CD1 1 
ATOM   4272 C CD2 . PHE A 1 589 ? -19.019 -10.454 14.433  1.00 40.08  ? 589 PHE A CD2 1 
ATOM   4273 C CE1 . PHE A 1 589 ? -18.146 -11.848 16.620  1.00 33.54  ? 589 PHE A CE1 1 
ATOM   4274 C CE2 . PHE A 1 589 ? -17.792 -11.122 14.404  1.00 36.09  ? 589 PHE A CE2 1 
ATOM   4275 C CZ  . PHE A 1 589 ? -17.366 -11.807 15.501  1.00 31.55  ? 589 PHE A CZ  1 
ATOM   4276 N N   . ASP A 1 590 ? -22.270 -6.776  14.850  1.00 48.81  ? 590 ASP A N   1 
ATOM   4277 C CA  . ASP A 1 590 ? -23.225 -5.715  14.577  1.00 46.94  ? 590 ASP A CA  1 
ATOM   4278 C C   . ASP A 1 590 ? -24.504 -6.274  13.971  1.00 45.02  ? 590 ASP A C   1 
ATOM   4279 O O   . ASP A 1 590 ? -24.491 -7.271  13.247  1.00 40.69  ? 590 ASP A O   1 
ATOM   4280 C CB  . ASP A 1 590 ? -22.625 -4.706  13.603  1.00 50.48  ? 590 ASP A CB  1 
ATOM   4281 C CG  . ASP A 1 590 ? -21.558 -3.842  14.235  1.00 62.85  ? 590 ASP A CG  1 
ATOM   4282 O OD1 . ASP A 1 590 ? -21.886 -3.043  15.142  1.00 68.97  ? 590 ASP A OD1 1 
ATOM   4283 O OD2 . ASP A 1 590 ? -20.380 -3.977  13.821  1.00 66.03  ? 590 ASP A OD2 1 
ATOM   4284 N N   . LYS A 1 591 ? -25.612 -5.599  14.261  1.00 46.96  ? 591 LYS A N   1 
ATOM   4285 C CA  . LYS A 1 591 ? -26.872 -5.855  13.575  1.00 43.48  ? 591 LYS A CA  1 
ATOM   4286 C C   . LYS A 1 591 ? -26.680 -5.711  12.066  1.00 43.52  ? 591 LYS A C   1 
ATOM   4287 O O   . LYS A 1 591 ? -25.826 -4.950  11.596  1.00 42.06  ? 591 LYS A O   1 
ATOM   4288 C CB  . LYS A 1 591 ? -27.902 -4.864  14.106  1.00 44.78  ? 591 LYS A CB  1 
ATOM   4289 C CG  . LYS A 1 591 ? -29.293 -4.829  13.527  1.00 43.36  ? 591 LYS A CG  1 
ATOM   4290 C CD  . LYS A 1 591 ? -30.035 -3.773  14.390  1.00 45.48  ? 591 LYS A CD  1 
ATOM   4291 C CE  . LYS A 1 591 ? -31.172 -3.037  13.698  1.00 46.07  ? 591 LYS A CE  1 
ATOM   4292 N NZ  . LYS A 1 591 ? -32.473 -3.783  13.696  1.00 47.39  ? 591 LYS A NZ  1 
ATOM   4293 N N   . THR A 1 592 ? -27.433 -6.489  11.290  1.00 37.48  ? 592 THR A N   1 
ATOM   4294 C CA  . THR A 1 592 ? -27.281 -6.386  9.842   1.00 34.29  ? 592 THR A CA  1 
ATOM   4295 C C   . THR A 1 592 ? -28.588 -6.446  9.060   1.00 38.58  ? 592 THR A C   1 
ATOM   4296 O O   . THR A 1 592 ? -28.552 -6.222  7.845   1.00 39.05  ? 592 THR A O   1 
ATOM   4297 C CB  . THR A 1 592 ? -26.333 -7.470  9.282   1.00 31.64  ? 592 THR A CB  1 
ATOM   4298 O OG1 . THR A 1 592 ? -26.898 -8.779  9.446   1.00 37.26  ? 592 THR A OG1 1 
ATOM   4299 C CG2 . THR A 1 592 ? -24.977 -7.433  9.943   1.00 39.37  ? 592 THR A CG2 1 
ATOM   4300 N N   . ILE A 1 593 ? -29.728 -6.728  9.675   1.00 32.35  ? 593 ILE A N   1 
ATOM   4301 C CA  . ILE A 1 593 ? -31.002 -6.679  8.976   1.00 39.11  ? 593 ILE A CA  1 
ATOM   4302 C C   . ILE A 1 593 ? -32.067 -6.236  9.974   1.00 46.37  ? 593 ILE A C   1 
ATOM   4303 O O   . ILE A 1 593 ? -31.806 -6.093  11.168  1.00 49.37  ? 593 ILE A O   1 
ATOM   4304 C CB  . ILE A 1 593 ? -31.377 -8.031  8.296   1.00 41.81  ? 593 ILE A CB  1 
ATOM   4305 C CG1 . ILE A 1 593 ? -31.401 -9.204  9.248   1.00 39.40  ? 593 ILE A CG1 1 
ATOM   4306 C CG2 . ILE A 1 593 ? -30.382 -8.455  7.232   1.00 39.19  ? 593 ILE A CG2 1 
ATOM   4307 C CD1 . ILE A 1 593 ? -31.728 -10.471 8.510   1.00 31.70  ? 593 ILE A CD1 1 
ATOM   4308 N N   . ASN A 1 594 ? -33.262 -5.955  9.465   1.00 50.49  ? 594 ASN A N   1 
ATOM   4309 C CA  . ASN A 1 594 ? -34.466 -5.786  10.267  1.00 56.04  ? 594 ASN A CA  1 
ATOM   4310 C C   . ASN A 1 594 ? -35.327 -7.035  10.125  1.00 60.25  ? 594 ASN A C   1 
ATOM   4311 O O   . ASN A 1 594 ? -35.233 -7.766  9.136   1.00 62.78  ? 594 ASN A O   1 
ATOM   4312 C CB  . ASN A 1 594 ? -35.271 -4.550  9.832   1.00 53.86  ? 594 ASN A CB  1 
ATOM   4313 C CG  . ASN A 1 594 ? -34.562 -3.250  10.130  1.00 54.93  ? 594 ASN A CG  1 
ATOM   4314 O OD1 . ASN A 1 594 ? -33.981 -3.073  11.202  1.00 51.44  ? 594 ASN A OD1 1 
ATOM   4315 N ND2 . ASN A 1 594 ? -34.628 -2.319  9.188   1.00 54.71  ? 594 ASN A ND2 1 
ATOM   4316 N N   . LYS A 1 595 ? -36.171 -7.277  11.123  1.00 56.43  ? 595 LYS A N   1 
ATOM   4317 C CA  . LYS A 1 595 ? -37.060 -8.423  11.048  1.00 55.19  ? 595 LYS A CA  1 
ATOM   4318 C C   . LYS A 1 595 ? -37.922 -8.340  9.789   1.00 66.33  ? 595 LYS A C   1 
ATOM   4319 O O   . LYS A 1 595 ? -38.248 -7.251  9.299   1.00 59.65  ? 595 LYS A O   1 
ATOM   4320 C CB  . LYS A 1 595 ? -37.934 -8.496  12.300  1.00 65.43  ? 595 LYS A CB  1 
ATOM   4321 C CG  . LYS A 1 595 ? -37.220 -9.031  13.550  1.00 65.60  ? 595 LYS A CG  1 
ATOM   4322 C CD  . LYS A 1 595 ? -38.215 -9.340  14.673  1.00 73.77  ? 595 LYS A CD  1 
ATOM   4323 C CE  . LYS A 1 595 ? -38.187 -8.305  15.801  1.00 74.35  ? 595 LYS A CE  1 
ATOM   4324 N NZ  . LYS A 1 595 ? -37.132 -8.602  16.816  1.00 63.57  ? 595 LYS A NZ  1 
ATOM   4325 N N   . GLY A 1 596 ? -38.262 -9.519  9.243   1.00 72.15  ? 596 GLY A N   1 
ATOM   4326 C CA  . GLY A 1 596 ? -39.047 -9.638  8.025   1.00 59.94  ? 596 GLY A CA  1 
ATOM   4327 C C   . GLY A 1 596 ? -38.265 -9.490  6.738   1.00 64.04  ? 596 GLY A C   1 
ATOM   4328 O O   . GLY A 1 596 ? -38.746 -9.932  5.682   1.00 60.59  ? 596 GLY A O   1 
ATOM   4329 N N   . ASP A 1 597 ? -37.064 -8.906  6.799   1.00 62.42  ? 597 ASP A N   1 
ATOM   4330 C CA  . ASP A 1 597 ? -36.304 -8.565  5.603   1.00 55.99  ? 597 ASP A CA  1 
ATOM   4331 C C   . ASP A 1 597 ? -35.920 -9.803  4.808   1.00 53.82  ? 597 ASP A C   1 
ATOM   4332 O O   . ASP A 1 597 ? -35.609 -10.859 5.364   1.00 55.29  ? 597 ASP A O   1 
ATOM   4333 C CB  . ASP A 1 597 ? -35.040 -7.796  5.975   1.00 57.20  ? 597 ASP A CB  1 
ATOM   4334 C CG  . ASP A 1 597 ? -35.296 -6.322  6.216   1.00 63.88  ? 597 ASP A CG  1 
ATOM   4335 O OD1 . ASP A 1 597 ? -36.479 -5.929  6.358   1.00 72.64  ? 597 ASP A OD1 1 
ATOM   4336 O OD2 . ASP A 1 597 ? -34.305 -5.557  6.265   1.00 57.98  ? 597 ASP A OD2 1 
ATOM   4337 N N   . THR A 1 598 ? -35.959 -9.658  3.487   1.00 54.66  ? 598 THR A N   1 
ATOM   4338 C CA  . THR A 1 598 ? -35.474 -10.677 2.576   1.00 46.89  ? 598 THR A CA  1 
ATOM   4339 C C   . THR A 1 598 ? -33.992 -10.422 2.346   1.00 43.84  ? 598 THR A C   1 
ATOM   4340 O O   . THR A 1 598 ? -33.551 -9.267  2.262   1.00 43.50  ? 598 THR A O   1 
ATOM   4341 C CB  . THR A 1 598 ? -36.267 -10.662 1.261   1.00 47.93  ? 598 THR A CB  1 
ATOM   4342 O OG1 . THR A 1 598 ? -35.672 -9.759  0.330   1.00 45.16  ? 598 THR A OG1 1 
ATOM   4343 C CG2 . THR A 1 598 ? -37.716 -10.213 1.507   1.00 53.17  ? 598 THR A CG2 1 
ATOM   4344 N N   . LEU A 1 599 ? -33.227 -11.514 2.286   1.00 40.47  ? 599 LEU A N   1 
ATOM   4345 C CA  . LEU A 1 599 ? -31.769 -11.494 2.415   1.00 34.40  ? 599 LEU A CA  1 
ATOM   4346 C C   . LEU A 1 599 ? -31.116 -11.270 1.068   1.00 33.41  ? 599 LEU A C   1 
ATOM   4347 O O   . LEU A 1 599 ? -31.051 -12.178 0.247   1.00 38.43  ? 599 LEU A O   1 
ATOM   4348 C CB  . LEU A 1 599 ? -31.291 -12.793 3.039   1.00 27.00  ? 599 LEU A CB  1 
ATOM   4349 C CG  . LEU A 1 599 ? -31.141 -12.893 4.552   1.00 29.90  ? 599 LEU A CG  1 
ATOM   4350 C CD1 . LEU A 1 599 ? -32.226 -12.221 5.318   1.00 34.32  ? 599 LEU A CD1 1 
ATOM   4351 C CD2 . LEU A 1 599 ? -31.196 -14.377 4.870   1.00 29.72  ? 599 LEU A CD2 1 
ATOM   4352 N N   . THR A 1 600 ? -30.623 -10.058 0.841   1.00 33.29  ? 600 THR A N   1 
ATOM   4353 C CA  . THR A 1 600 ? -29.840 -9.739  -0.341  1.00 32.75  ? 600 THR A CA  1 
ATOM   4354 C C   . THR A 1 600 ? -28.360 -9.722  0.045   1.00 25.51  ? 600 THR A C   1 
ATOM   4355 O O   . THR A 1 600 ? -27.991 -10.069 1.165   1.00 24.44  ? 600 THR A O   1 
ATOM   4356 C CB  . THR A 1 600 ? -30.319 -8.421  -0.960  1.00 34.02  ? 600 THR A CB  1 
ATOM   4357 O OG1 . THR A 1 600 ? -29.660 -7.303  -0.342  1.00 39.59  ? 600 THR A OG1 1 
ATOM   4358 C CG2 . THR A 1 600 ? -31.809 -8.280  -0.749  1.00 30.35  ? 600 THR A CG2 1 
ATOM   4359 N N   . TYR A 1 601 ? -27.509 -9.327  -0.905  1.00 25.22  ? 601 TYR A N   1 
ATOM   4360 C CA  . TYR A 1 601 ? -26.059 -9.344  -0.702  1.00 29.76  ? 601 TYR A CA  1 
ATOM   4361 C C   . TYR A 1 601 ? -25.646 -8.638  0.579   1.00 30.82  ? 601 TYR A C   1 
ATOM   4362 O O   . TYR A 1 601 ? -24.907 -9.197  1.399   1.00 32.32  ? 601 TYR A O   1 
ATOM   4363 C CB  . TYR A 1 601 ? -25.363 -8.667  -1.873  1.00 33.08  ? 601 TYR A CB  1 
ATOM   4364 C CG  . TYR A 1 601 ? -23.845 -8.709  -1.821  1.00 30.40  ? 601 TYR A CG  1 
ATOM   4365 C CD1 . TYR A 1 601 ? -23.143 -9.848  -2.183  1.00 24.43  ? 601 TYR A CD1 1 
ATOM   4366 C CD2 . TYR A 1 601 ? -23.111 -7.595  -1.389  1.00 29.84  ? 601 TYR A CD2 1 
ATOM   4367 C CE1 . TYR A 1 601 ? -21.763 -9.874  -2.152  1.00 22.19  ? 601 TYR A CE1 1 
ATOM   4368 C CE2 . TYR A 1 601 ? -21.718 -7.629  -1.352  1.00 27.27  ? 601 TYR A CE2 1 
ATOM   4369 C CZ  . TYR A 1 601 ? -21.068 -8.779  -1.730  1.00 22.54  ? 601 TYR A CZ  1 
ATOM   4370 O OH  . TYR A 1 601 ? -19.715 -8.829  -1.691  1.00 26.35  ? 601 TYR A OH  1 
ATOM   4371 N N   . ASN A 1 602 ? -26.081 -7.380  0.736   1.00 31.43  ? 602 ASN A N   1 
ATOM   4372 C CA  . ASN A 1 602 ? -25.680 -6.562  1.875   1.00 31.12  ? 602 ASN A CA  1 
ATOM   4373 C C   . ASN A 1 602 ? -26.197 -7.096  3.212   1.00 36.52  ? 602 ASN A C   1 
ATOM   4374 O O   . ASN A 1 602 ? -25.633 -6.735  4.254   1.00 39.97  ? 602 ASN A O   1 
ATOM   4375 C CB  . ASN A 1 602 ? -26.172 -5.130  1.698   1.00 34.04  ? 602 ASN A CB  1 
ATOM   4376 C CG  . ASN A 1 602 ? -25.320 -4.316  0.734   1.00 42.48  ? 602 ASN A CG  1 
ATOM   4377 O OD1 . ASN A 1 602 ? -24.126 -4.601  0.515   1.00 41.98  ? 602 ASN A OD1 1 
ATOM   4378 N ND2 . ASN A 1 602 ? -25.933 -3.278  0.156   1.00 40.06  ? 602 ASN A ND2 1 
ATOM   4379 N N   . SER A 1 603 ? -27.263 -7.915  3.215   1.00 30.58  ? 603 SER A N   1 
ATOM   4380 C CA  . SER A 1 603 ? -27.713 -8.556  4.448   1.00 27.93  ? 603 SER A CA  1 
ATOM   4381 C C   . SER A 1 603 ? -26.553 -9.166  5.237   1.00 36.90  ? 603 SER A C   1 
ATOM   4382 O O   . SER A 1 603 ? -26.525 -9.091  6.471   1.00 42.36  ? 603 SER A O   1 
ATOM   4383 C CB  . SER A 1 603 ? -28.739 -9.647  4.147   1.00 29.19  ? 603 SER A CB  1 
ATOM   4384 O OG  . SER A 1 603 ? -29.888 -9.145  3.514   1.00 31.97  ? 603 SER A OG  1 
ATOM   4385 N N   . PHE A 1 604 ? -25.597 -9.798  4.558   1.00 35.86  ? 604 PHE A N   1 
ATOM   4386 C CA  . PHE A 1 604 ? -24.519 -10.507 5.238   1.00 33.87  ? 604 PHE A CA  1 
ATOM   4387 C C   . PHE A 1 604 ? -23.305 -9.615  5.378   1.00 36.31  ? 604 PHE A C   1 
ATOM   4388 O O   . PHE A 1 604 ? -22.802 -9.083  4.379   1.00 40.78  ? 604 PHE A O   1 
ATOM   4389 C CB  . PHE A 1 604 ? -24.107 -11.779 4.500   1.00 33.62  ? 604 PHE A CB  1 
ATOM   4390 C CG  . PHE A 1 604 ? -25.101 -12.868 4.594   1.00 31.51  ? 604 PHE A CG  1 
ATOM   4391 C CD1 . PHE A 1 604 ? -26.207 -12.891 3.758   1.00 29.61  ? 604 PHE A CD1 1 
ATOM   4392 C CD2 . PHE A 1 604 ? -24.920 -13.895 5.503   1.00 34.48  ? 604 PHE A CD2 1 
ATOM   4393 C CE1 . PHE A 1 604 ? -27.129 -13.912 3.849   1.00 31.78  ? 604 PHE A CE1 1 
ATOM   4394 C CE2 . PHE A 1 604 ? -25.840 -14.932 5.599   1.00 29.92  ? 604 PHE A CE2 1 
ATOM   4395 C CZ  . PHE A 1 604 ? -26.951 -14.934 4.770   1.00 30.34  ? 604 PHE A CZ  1 
ATOM   4396 N N   . ASN A 1 605 ? -22.820 -9.506  6.608   1.00 31.73  ? 605 ASN A N   1 
ATOM   4397 C CA  . ASN A 1 605 ? -21.581 -8.842  6.955   1.00 29.69  ? 605 ASN A CA  1 
ATOM   4398 C C   . ASN A 1 605 ? -20.529 -9.912  7.236   1.00 30.45  ? 605 ASN A C   1 
ATOM   4399 O O   . ASN A 1 605 ? -20.860 -11.057 7.545   1.00 28.66  ? 605 ASN A O   1 
ATOM   4400 C CB  . ASN A 1 605 ? -21.846 -7.917  8.157   1.00 35.96  ? 605 ASN A CB  1 
ATOM   4401 C CG  . ASN A 1 605 ? -20.581 -7.392  8.808   1.00 42.29  ? 605 ASN A CG  1 
ATOM   4402 O OD1 . ASN A 1 605 ? -19.560 -7.205  8.141   1.00 45.06  ? 605 ASN A OD1 1 
ATOM   4403 N ND2 . ASN A 1 605 ? -20.649 -7.122  10.120  1.00 34.83  ? 605 ASN A ND2 1 
ATOM   4404 N N   . LEU A 1 606 ? -19.255 -9.546  7.082   1.00 31.54  ? 606 LEU A N   1 
ATOM   4405 C CA  . LEU A 1 606 ? -18.114 -10.428 7.345   1.00 29.90  ? 606 LEU A CA  1 
ATOM   4406 C C   . LEU A 1 606 ? -17.182 -9.738  8.327   1.00 37.69  ? 606 LEU A C   1 
ATOM   4407 O O   . LEU A 1 606 ? -16.593 -8.711  7.985   1.00 47.21  ? 606 LEU A O   1 
ATOM   4408 C CB  . LEU A 1 606 ? -17.347 -10.734 6.064   1.00 23.46  ? 606 LEU A CB  1 
ATOM   4409 C CG  . LEU A 1 606 ? -16.033 -11.511 6.135   1.00 29.76  ? 606 LEU A CG  1 
ATOM   4410 C CD1 . LEU A 1 606 ? -16.202 -13.032 6.350   1.00 31.05  ? 606 LEU A CD1 1 
ATOM   4411 C CD2 . LEU A 1 606 ? -15.163 -11.210 4.912   1.00 30.20  ? 606 LEU A CD2 1 
ATOM   4412 N N   . ALA A 1 607 ? -17.013 -10.308 9.527   1.00 37.29  ? 607 ALA A N   1 
ATOM   4413 C CA  . ALA A 1 607 ? -16.373 -9.596  10.631  1.00 37.34  ? 607 ALA A CA  1 
ATOM   4414 C C   . ALA A 1 607 ? -15.292 -10.422 11.329  1.00 39.89  ? 607 ALA A C   1 
ATOM   4415 O O   . ALA A 1 607 ? -15.474 -11.619 11.572  1.00 40.33  ? 607 ALA A O   1 
ATOM   4416 C CB  . ALA A 1 607 ? -17.438 -9.178  11.638  1.00 38.42  ? 607 ALA A CB  1 
ATOM   4417 N N   . SER A 1 608 ? -14.181 -9.769  11.679  1.00 36.61  ? 608 SER A N   1 
ATOM   4418 C CA  . SER A 1 608 ? -13.066 -10.436 12.345  1.00 38.61  ? 608 SER A CA  1 
ATOM   4419 C C   . SER A 1 608 ? -13.330 -10.637 13.830  1.00 38.85  ? 608 SER A C   1 
ATOM   4420 O O   . SER A 1 608 ? -14.053 -9.866  14.460  1.00 41.89  ? 608 SER A O   1 
ATOM   4421 C CB  . SER A 1 608 ? -11.763 -9.638  12.207  1.00 39.88  ? 608 SER A CB  1 
ATOM   4422 O OG  . SER A 1 608 ? -11.208 -9.687  10.905  1.00 39.73  ? 608 SER A OG  1 
ATOM   4423 N N   . PHE A 1 609 ? -12.730 -11.697 14.383  1.00 42.38  ? 609 PHE A N   1 
ATOM   4424 C CA  . PHE A 1 609 ? -12.525 -11.870 15.820  1.00 43.00  ? 609 PHE A CA  1 
ATOM   4425 C C   . PHE A 1 609 ? -11.216 -11.212 16.244  1.00 49.57  ? 609 PHE A C   1 
ATOM   4426 O O   . PHE A 1 609 ? -10.290 -11.038 15.449  1.00 55.43  ? 609 PHE A O   1 
ATOM   4427 C CB  . PHE A 1 609 ? -12.522 -13.361 16.216  1.00 41.50  ? 609 PHE A CB  1 
ATOM   4428 C CG  . PHE A 1 609 ? -13.902 -13.995 16.224  1.00 38.68  ? 609 PHE A CG  1 
ATOM   4429 C CD1 . PHE A 1 609 ? -14.500 -14.440 15.057  1.00 37.60  ? 609 PHE A CD1 1 
ATOM   4430 C CD2 . PHE A 1 609 ? -14.609 -14.122 17.406  1.00 38.81  ? 609 PHE A CD2 1 
ATOM   4431 C CE1 . PHE A 1 609 ? -15.783 -14.994 15.076  1.00 37.30  ? 609 PHE A CE1 1 
ATOM   4432 C CE2 . PHE A 1 609 ? -15.887 -14.673 17.429  1.00 35.02  ? 609 PHE A CE2 1 
ATOM   4433 C CZ  . PHE A 1 609 ? -16.469 -15.108 16.266  1.00 34.91  ? 609 PHE A CZ  1 
ATOM   4434 N N   . SER A 1 610 ? -11.147 -10.842 17.520  1.00 54.02  ? 610 SER A N   1 
ATOM   4435 C CA  . SER A 1 610 ? -9.984  -10.115 18.022  1.00 56.23  ? 610 SER A CA  1 
ATOM   4436 C C   . SER A 1 610 ? -8.738  -10.995 18.040  1.00 60.02  ? 610 SER A C   1 
ATOM   4437 O O   . SER A 1 610 ? -7.693  -10.620 17.490  1.00 64.12  ? 610 SER A O   1 
ATOM   4438 C CB  . SER A 1 610 ? -10.270 -9.563  19.427  1.00 61.17  ? 610 SER A CB  1 
ATOM   4439 O OG  . SER A 1 610 ? -10.959 -10.507 20.253  1.00 62.76  ? 610 SER A OG  1 
ATOM   4440 N N   . THR A 1 611 ? -8.838  -12.218 18.671  1.00 54.19  ? 611 THR A N   1 
ATOM   4441 C CA  . THR A 1 611 ? -7.651  -12.910 19.164  1.00 55.41  ? 611 THR A CA  1 
ATOM   4442 C C   . THR A 1 611 ? -7.179  -14.016 18.230  1.00 53.25  ? 611 THR A C   1 
ATOM   4443 O O   . THR A 1 611 ? -7.979  -14.865 17.810  1.00 51.27  ? 611 THR A O   1 
ATOM   4444 C CB  . THR A 1 611 ? -7.911  -13.493 20.554  1.00 57.14  ? 611 THR A CB  1 
ATOM   4445 O OG1 . THR A 1 611 ? -8.523  -12.503 21.385  1.00 61.10  ? 611 THR A OG1 1 
ATOM   4446 C CG2 . THR A 1 611 ? -6.600  -13.964 21.203  1.00 55.70  ? 611 THR A CG2 1 
ATOM   4447 N N   . PRO A 1 612 ? -5.881  -14.026 17.931  1.00 48.54  ? 612 PRO A N   1 
ATOM   4448 C CA  . PRO A 1 612 ? -5.244  -15.200 17.322  1.00 51.07  ? 612 PRO A CA  1 
ATOM   4449 C C   . PRO A 1 612 ? -5.372  -16.435 18.204  1.00 52.16  ? 612 PRO A C   1 
ATOM   4450 O O   . PRO A 1 612 ? -5.571  -16.338 19.419  1.00 50.60  ? 612 PRO A O   1 
ATOM   4451 C CB  . PRO A 1 612 ? -3.771  -14.790 17.207  1.00 55.60  ? 612 PRO A CB  1 
ATOM   4452 C CG  . PRO A 1 612 ? -3.711  -13.355 17.509  1.00 55.64  ? 612 PRO A CG  1 
ATOM   4453 C CD  . PRO A 1 612 ? -4.934  -12.940 18.219  1.00 49.88  ? 612 PRO A CD  1 
ATOM   4454 N N   . PHE A 1 613 ? -5.186  -17.608 17.584  1.00 47.61  ? 613 PHE A N   1 
ATOM   4455 C CA  . PHE A 1 613 ? -5.356  -18.894 18.264  1.00 44.20  ? 613 PHE A CA  1 
ATOM   4456 C C   . PHE A 1 613 ? -4.675  -20.002 17.480  1.00 49.95  ? 613 PHE A C   1 
ATOM   4457 O O   . PHE A 1 613 ? -4.366  -19.846 16.301  1.00 57.46  ? 613 PHE A O   1 
ATOM   4458 C CB  . PHE A 1 613 ? -6.824  -19.256 18.438  1.00 42.71  ? 613 PHE A CB  1 
ATOM   4459 C CG  . PHE A 1 613 ? -7.575  -19.365 17.154  1.00 41.45  ? 613 PHE A CG  1 
ATOM   4460 C CD1 . PHE A 1 613 ? -7.605  -20.545 16.444  1.00 42.72  ? 613 PHE A CD1 1 
ATOM   4461 C CD2 . PHE A 1 613 ? -8.329  -18.305 16.696  1.00 44.19  ? 613 PHE A CD2 1 
ATOM   4462 C CE1 . PHE A 1 613 ? -8.318  -20.644 15.258  1.00 38.81  ? 613 PHE A CE1 1 
ATOM   4463 C CE2 . PHE A 1 613 ? -9.048  -18.408 15.520  1.00 40.50  ? 613 PHE A CE2 1 
ATOM   4464 C CZ  . PHE A 1 613 ? -9.035  -19.582 14.806  1.00 36.89  ? 613 PHE A CZ  1 
ATOM   4465 N N   . GLU A 1 614 ? -4.492  -21.149 18.139  1.00 54.18  ? 614 GLU A N   1 
ATOM   4466 C CA  . GLU A 1 614 ? -3.979  -22.361 17.508  1.00 54.01  ? 614 GLU A CA  1 
ATOM   4467 C C   . GLU A 1 614 ? -5.098  -23.381 17.332  1.00 52.62  ? 614 GLU A C   1 
ATOM   4468 O O   . GLU A 1 614 ? -6.116  -23.348 18.028  1.00 53.93  ? 614 GLU A O   1 
ATOM   4469 C CB  . GLU A 1 614 ? -2.868  -23.011 18.338  1.00 61.38  ? 614 GLU A CB  1 
ATOM   4470 C CG  . GLU A 1 614 ? -1.721  -22.110 18.768  1.00 71.83  ? 614 GLU A CG  1 
ATOM   4471 C CD  . GLU A 1 614 ? -0.951  -22.699 19.957  1.00 86.01  ? 614 GLU A CD  1 
ATOM   4472 O OE1 . GLU A 1 614 ? -0.889  -23.950 20.062  1.00 79.32  ? 614 GLU A OE1 1 
ATOM   4473 O OE2 . GLU A 1 614 ? -0.420  -21.919 20.787  1.00 83.87  ? 614 GLU A OE2 1 
ATOM   4474 N N   . LEU A 1 615 ? -4.891  -24.321 16.418  1.00 49.90  ? 615 LEU A N   1 
ATOM   4475 C CA  . LEU A 1 615 ? -5.871  -25.390 16.215  1.00 52.00  ? 615 LEU A CA  1 
ATOM   4476 C C   . LEU A 1 615 ? -5.431  -26.655 16.948  1.00 55.81  ? 615 LEU A C   1 
ATOM   4477 O O   . LEU A 1 615 ? -5.055  -27.671 16.347  1.00 51.33  ? 615 LEU A O   1 
ATOM   4478 C CB  . LEU A 1 615 ? -6.085  -25.663 14.730  1.00 52.60  ? 615 LEU A CB  1 
ATOM   4479 C CG  . LEU A 1 615 ? -7.002  -24.708 13.986  1.00 40.89  ? 615 LEU A CG  1 
ATOM   4480 C CD1 . LEU A 1 615 ? -6.966  -25.074 12.551  1.00 43.91  ? 615 LEU A CD1 1 
ATOM   4481 C CD2 . LEU A 1 615 ? -8.391  -24.834 14.522  1.00 35.92  ? 615 LEU A CD2 1 
ATOM   4482 N N   . SER A 1 616 ? -5.511  -26.569 18.277  1.00 56.52  ? 616 SER A N   1 
ATOM   4483 C CA  . SER A 1 616 ? -5.241  -27.697 19.169  1.00 56.12  ? 616 SER A CA  1 
ATOM   4484 C C   . SER A 1 616 ? -6.566  -28.340 19.576  1.00 58.93  ? 616 SER A C   1 
ATOM   4485 O O   . SER A 1 616 ? -7.043  -28.222 20.713  1.00 64.79  ? 616 SER A O   1 
ATOM   4486 C CB  . SER A 1 616 ? -4.463  -27.221 20.378  1.00 61.35  ? 616 SER A CB  1 
ATOM   4487 O OG  . SER A 1 616 ? -5.109  -26.066 20.886  1.00 65.73  ? 616 SER A OG  1 
ATOM   4488 N N   . GLY A 1 617 ? -7.163  -29.007 18.596  1.00 51.74  ? 617 GLY A N   1 
ATOM   4489 C CA  . GLY A 1 617 ? -8.470  -29.612 18.744  1.00 48.63  ? 617 GLY A CA  1 
ATOM   4490 C C   . GLY A 1 617 ? -8.967  -30.028 17.381  1.00 50.19  ? 617 GLY A C   1 
ATOM   4491 O O   . GLY A 1 617 ? -8.232  -29.974 16.390  1.00 55.43  ? 617 GLY A O   1 
ATOM   4492 N N   . ASN A 1 618 ? -10.227 -30.466 17.344  1.00 43.47  ? 618 ASN A N   1 
ATOM   4493 C CA  . ASN A 1 618 ? -10.908 -30.693 16.071  1.00 43.58  ? 618 ASN A CA  1 
ATOM   4494 C C   . ASN A 1 618 ? -12.338 -30.209 16.031  1.00 42.25  ? 618 ASN A C   1 
ATOM   4495 O O   . ASN A 1 618 ? -12.875 -30.031 14.928  1.00 37.91  ? 618 ASN A O   1 
ATOM   4496 C CB  . ASN A 1 618 ? -10.941 -32.181 15.698  1.00 44.15  ? 618 ASN A CB  1 
ATOM   4497 C CG  . ASN A 1 618 ? -9.609  -32.810 15.703  1.00 38.98  ? 618 ASN A CG  1 
ATOM   4498 O OD1 . ASN A 1 618 ? -9.002  -32.972 16.754  1.00 49.10  ? 618 ASN A OD1 1 
ATOM   4499 N ND2 . ASN A 1 618 ? -9.114  -33.142 14.529  1.00 37.92  ? 618 ASN A ND2 1 
ATOM   4500 N N   . ASN A 1 619 ? -12.986 -30.040 17.176  1.00 45.04  ? 619 ASN A N   1 
ATOM   4501 C CA  . ASN A 1 619 ? -14.431 -29.871 17.236  1.00 44.95  ? 619 ASN A CA  1 
ATOM   4502 C C   . ASN A 1 619 ? -14.711 -28.398 17.455  1.00 42.21  ? 619 ASN A C   1 
ATOM   4503 O O   . ASN A 1 619 ? -14.750 -27.906 18.581  1.00 49.09  ? 619 ASN A O   1 
ATOM   4504 C CB  . ASN A 1 619 ? -15.042 -30.756 18.315  1.00 43.57  ? 619 ASN A CB  1 
ATOM   4505 C CG  . ASN A 1 619 ? -15.014 -32.227 17.934  1.00 47.28  ? 619 ASN A CG  1 
ATOM   4506 O OD1 . ASN A 1 619 ? -16.060 -32.826 17.671  1.00 52.55  ? 619 ASN A OD1 1 
ATOM   4507 N ND2 . ASN A 1 619 ? -13.816 -32.811 17.869  1.00 48.05  ? 619 ASN A ND2 1 
ATOM   4508 N N   . LEU A 1 620 ? -14.892 -27.692 16.354  1.00 38.01  ? 620 LEU A N   1 
ATOM   4509 C CA  . LEU A 1 620 ? -15.305 -26.310 16.422  1.00 40.77  ? 620 LEU A CA  1 
ATOM   4510 C C   . LEU A 1 620 ? -16.783 -26.263 16.753  1.00 44.05  ? 620 LEU A C   1 
ATOM   4511 O O   . LEU A 1 620 ? -17.596 -26.885 16.062  1.00 49.74  ? 620 LEU A O   1 
ATOM   4512 C CB  . LEU A 1 620 ? -15.009 -25.615 15.105  1.00 37.25  ? 620 LEU A CB  1 
ATOM   4513 C CG  . LEU A 1 620 ? -15.162 -24.110 15.107  1.00 44.11  ? 620 LEU A CG  1 
ATOM   4514 C CD1 . LEU A 1 620 ? -14.180 -23.437 16.065  1.00 41.28  ? 620 LEU A CD1 1 
ATOM   4515 C CD2 . LEU A 1 620 ? -14.861 -23.685 13.714  1.00 47.18  ? 620 LEU A CD2 1 
ATOM   4516 N N   . GLN A 1 621 ? -17.123 -25.578 17.840  1.00 37.27  ? 621 GLN A N   1 
ATOM   4517 C CA  . GLN A 1 621 ? -18.508 -25.342 18.214  1.00 44.26  ? 621 GLN A CA  1 
ATOM   4518 C C   . GLN A 1 621 ? -18.797 -23.846 18.241  1.00 48.66  ? 621 GLN A C   1 
ATOM   4519 O O   . GLN A 1 621 ? -18.082 -23.074 18.897  1.00 56.11  ? 621 GLN A O   1 
ATOM   4520 C CB  . GLN A 1 621 ? -18.836 -25.965 19.566  1.00 50.50  ? 621 GLN A CB  1 
ATOM   4521 C CG  . GLN A 1 621 ? -20.274 -25.720 19.944  1.00 54.66  ? 621 GLN A CG  1 
ATOM   4522 C CD  . GLN A 1 621 ? -20.435 -25.578 21.429  1.00 65.41  ? 621 GLN A CD  1 
ATOM   4523 O OE1 . GLN A 1 621 ? -20.657 -24.475 21.953  1.00 63.76  ? 621 GLN A OE1 1 
ATOM   4524 N NE2 . GLN A 1 621 ? -20.379 -26.708 22.126  1.00 74.92  ? 621 GLN A NE2 1 
ATOM   4525 N N   . ILE A 1 622 ? -19.852 -23.441 17.544  1.00 41.31  ? 622 ILE A N   1 
ATOM   4526 C CA  . ILE A 1 622 ? -20.184 -22.038 17.359  1.00 43.22  ? 622 ILE A CA  1 
ATOM   4527 C C   . ILE A 1 622 ? -21.420 -21.747 18.186  1.00 44.44  ? 622 ILE A C   1 
ATOM   4528 O O   . ILE A 1 622 ? -22.383 -22.522 18.160  1.00 50.03  ? 622 ILE A O   1 
ATOM   4529 C CB  . ILE A 1 622 ? -20.402 -21.711 15.870  1.00 43.51  ? 622 ILE A CB  1 
ATOM   4530 C CG1 . ILE A 1 622 ? -19.080 -21.769 15.107  1.00 51.28  ? 622 ILE A CG1 1 
ATOM   4531 C CG2 . ILE A 1 622 ? -21.001 -20.353 15.678  1.00 38.27  ? 622 ILE A CG2 1 
ATOM   4532 C CD1 . ILE A 1 622 ? -18.676 -23.166 14.627  1.00 48.51  ? 622 ILE A CD1 1 
ATOM   4533 N N   . GLY A 1 623 ? -21.392 -20.646 18.932  1.00 38.50  ? 623 GLY A N   1 
ATOM   4534 C CA  . GLY A 1 623 ? -22.514 -20.281 19.760  1.00 44.90  ? 623 GLY A CA  1 
ATOM   4535 C C   . GLY A 1 623 ? -22.880 -18.824 19.574  1.00 47.21  ? 623 GLY A C   1 
ATOM   4536 O O   . GLY A 1 623 ? -22.053 -17.999 19.191  1.00 48.70  ? 623 GLY A O   1 
ATOM   4537 N N   . VAL A 1 624 ? -24.147 -18.527 19.879  1.00 45.64  ? 624 VAL A N   1 
ATOM   4538 C CA  . VAL A 1 624 ? -24.769 -17.224 19.685  1.00 40.67  ? 624 VAL A CA  1 
ATOM   4539 C C   . VAL A 1 624 ? -25.387 -16.810 21.005  1.00 46.03  ? 624 VAL A C   1 
ATOM   4540 O O   . VAL A 1 624 ? -26.065 -17.618 21.647  1.00 56.36  ? 624 VAL A O   1 
ATOM   4541 C CB  . VAL A 1 624 ? -25.883 -17.288 18.618  1.00 47.21  ? 624 VAL A CB  1 
ATOM   4542 C CG1 . VAL A 1 624 ? -26.414 -15.912 18.335  1.00 54.73  ? 624 VAL A CG1 1 
ATOM   4543 C CG2 . VAL A 1 624 ? -25.426 -17.978 17.355  1.00 47.33  ? 624 VAL A CG2 1 
ATOM   4544 N N   . THR A 1 625 ? -25.195 -15.558 21.411  1.00 45.79  ? 625 THR A N   1 
ATOM   4545 C CA  . THR A 1 625 ? -26.040 -15.005 22.471  1.00 47.29  ? 625 THR A CA  1 
ATOM   4546 C C   . THR A 1 625 ? -26.440 -13.585 22.104  1.00 47.15  ? 625 THR A C   1 
ATOM   4547 O O   . THR A 1 625 ? -25.808 -12.931 21.276  1.00 50.68  ? 625 THR A O   1 
ATOM   4548 C CB  . THR A 1 625 ? -25.370 -14.975 23.856  1.00 46.55  ? 625 THR A CB  1 
ATOM   4549 O OG1 . THR A 1 625 ? -24.356 -13.962 23.887  1.00 49.60  ? 625 THR A OG1 1 
ATOM   4550 C CG2 . THR A 1 625 ? -24.741 -16.309 24.195  1.00 38.13  ? 625 THR A CG2 1 
ATOM   4551 N N   . GLY A 1 626 ? -27.478 -13.096 22.754  1.00 47.97  ? 626 GLY A N   1 
ATOM   4552 C CA  . GLY A 1 626 ? -27.994 -11.773 22.476  1.00 45.86  ? 626 GLY A CA  1 
ATOM   4553 C C   . GLY A 1 626 ? -29.385 -11.781 21.901  1.00 42.16  ? 626 GLY A C   1 
ATOM   4554 O O   . GLY A 1 626 ? -30.003 -10.713 21.782  1.00 46.29  ? 626 GLY A O   1 
ATOM   4555 N N   . LEU A 1 627 ? -29.904 -12.949 21.552  1.00 37.49  ? 627 LEU A N   1 
ATOM   4556 C CA  . LEU A 1 627 ? -31.196 -13.008 20.893  1.00 47.59  ? 627 LEU A CA  1 
ATOM   4557 C C   . LEU A 1 627 ? -32.305 -12.723 21.890  1.00 49.29  ? 627 LEU A C   1 
ATOM   4558 O O   . LEU A 1 627 ? -32.453 -13.444 22.879  1.00 55.69  ? 627 LEU A O   1 
ATOM   4559 C CB  . LEU A 1 627 ? -31.423 -14.374 20.244  1.00 45.11  ? 627 LEU A CB  1 
ATOM   4560 C CG  . LEU A 1 627 ? -30.365 -15.024 19.365  1.00 42.00  ? 627 LEU A CG  1 
ATOM   4561 C CD1 . LEU A 1 627 ? -30.980 -16.173 18.609  1.00 48.71  ? 627 LEU A CD1 1 
ATOM   4562 C CD2 . LEU A 1 627 ? -29.794 -14.035 18.428  1.00 44.38  ? 627 LEU A CD2 1 
ATOM   4563 N N   . SER A 1 628 ? -33.089 -11.683 21.627  1.00 48.90  ? 628 SER A N   1 
ATOM   4564 C CA  . SER A 1 628 ? -34.423 -11.593 22.197  1.00 47.70  ? 628 SER A CA  1 
ATOM   4565 C C   . SER A 1 628 ? -35.371 -12.489 21.387  1.00 55.46  ? 628 SER A C   1 
ATOM   4566 O O   . SER A 1 628 ? -34.961 -13.201 20.461  1.00 49.51  ? 628 SER A O   1 
ATOM   4567 C CB  . SER A 1 628 ? -34.872 -10.137 22.233  1.00 51.11  ? 628 SER A CB  1 
ATOM   4568 O OG  . SER A 1 628 ? -33.917 -9.339  22.925  1.00 51.17  ? 628 SER A OG  1 
ATOM   4569 N N   . ALA A 1 629 ? -36.655 -12.491 21.737  1.00 61.24  ? 629 ALA A N   1 
ATOM   4570 C CA  . ALA A 1 629 ? -37.594 -13.351 21.028  1.00 51.29  ? 629 ALA A CA  1 
ATOM   4571 C C   . ALA A 1 629 ? -37.962 -12.729 19.691  1.00 55.43  ? 629 ALA A C   1 
ATOM   4572 O O   . ALA A 1 629 ? -38.191 -11.522 19.590  1.00 56.42  ? 629 ALA A O   1 
ATOM   4573 C CB  . ALA A 1 629 ? -38.850 -13.600 21.855  1.00 44.69  ? 629 ALA A CB  1 
ATOM   4574 N N   . GLY A 1 630 ? -38.028 -13.570 18.663  1.00 64.29  ? 630 GLY A N   1 
ATOM   4575 C CA  . GLY A 1 630 ? -38.234 -13.099 17.314  1.00 59.16  ? 630 GLY A CA  1 
ATOM   4576 C C   . GLY A 1 630 ? -36.969 -12.671 16.616  1.00 63.04  ? 630 GLY A C   1 
ATOM   4577 O O   . GLY A 1 630 ? -37.044 -12.056 15.543  1.00 66.46  ? 630 GLY A O   1 
ATOM   4578 N N   . ASP A 1 631 ? -35.808 -12.955 17.196  1.00 56.92  ? 631 ASP A N   1 
ATOM   4579 C CA  . ASP A 1 631 ? -34.557 -12.675 16.518  1.00 50.84  ? 631 ASP A CA  1 
ATOM   4580 C C   . ASP A 1 631 ? -34.149 -13.861 15.662  1.00 47.53  ? 631 ASP A C   1 
ATOM   4581 O O   . ASP A 1 631 ? -34.525 -15.009 15.922  1.00 51.94  ? 631 ASP A O   1 
ATOM   4582 C CB  . ASP A 1 631 ? -33.426 -12.344 17.497  1.00 48.38  ? 631 ASP A CB  1 
ATOM   4583 C CG  . ASP A 1 631 ? -33.491 -10.905 18.022  1.00 53.13  ? 631 ASP A CG  1 
ATOM   4584 O OD1 . ASP A 1 631 ? -33.875 -9.969  17.263  1.00 50.57  ? 631 ASP A OD1 1 
ATOM   4585 O OD2 . ASP A 1 631 ? -33.083 -10.702 19.192  1.00 56.06  ? 631 ASP A OD2 1 
ATOM   4586 N N   . LYS A 1 632 ? -33.382 -13.567 14.630  1.00 41.45  ? 632 LYS A N   1 
ATOM   4587 C CA  . LYS A 1 632 ? -32.766 -14.586 13.809  1.00 40.70  ? 632 LYS A CA  1 
ATOM   4588 C C   . LYS A 1 632 ? -31.307 -14.244 13.568  1.00 40.93  ? 632 LYS A C   1 
ATOM   4589 O O   . LYS A 1 632 ? -30.969 -13.095 13.289  1.00 44.92  ? 632 LYS A O   1 
ATOM   4590 C CB  . LYS A 1 632 ? -33.475 -14.747 12.466  1.00 39.91  ? 632 LYS A CB  1 
ATOM   4591 C CG  . LYS A 1 632 ? -34.467 -15.903 12.347  1.00 43.22  ? 632 LYS A CG  1 
ATOM   4592 C CD  . LYS A 1 632 ? -35.912 -15.607 12.620  1.00 41.04  ? 632 LYS A CD  1 
ATOM   4593 C CE  . LYS A 1 632 ? -36.675 -16.918 12.680  1.00 43.36  ? 632 LYS A CE  1 
ATOM   4594 N NZ  . LYS A 1 632 ? -38.124 -16.687 12.846  1.00 50.20  ? 632 LYS A NZ  1 
ATOM   4595 N N   . VAL A 1 633 ? -30.450 -15.238 13.700  1.00 36.58  ? 633 VAL A N   1 
ATOM   4596 C CA  . VAL A 1 633 ? -29.108 -15.200 13.153  1.00 34.59  ? 633 VAL A CA  1 
ATOM   4597 C C   . VAL A 1 633 ? -29.032 -16.211 12.023  1.00 40.55  ? 633 VAL A C   1 
ATOM   4598 O O   . VAL A 1 633 ? -29.580 -17.314 12.124  1.00 46.00  ? 633 VAL A O   1 
ATOM   4599 C CB  . VAL A 1 633 ? -28.067 -15.518 14.229  1.00 38.35  ? 633 VAL A CB  1 
ATOM   4600 C CG1 . VAL A 1 633 ? -26.690 -15.202 13.719  1.00 42.71  ? 633 VAL A CG1 1 
ATOM   4601 C CG2 . VAL A 1 633 ? -28.360 -14.727 15.442  1.00 41.73  ? 633 VAL A CG2 1 
ATOM   4602 N N   . TYR A 1 634 ? -28.359 -15.846 10.943  1.00 33.99  ? 634 TYR A N   1 
ATOM   4603 C CA  . TYR A 1 634 ? -28.061 -16.793 9.887   1.00 27.53  ? 634 TYR A CA  1 
ATOM   4604 C C   . TYR A 1 634 ? -26.552 -16.838 9.785   1.00 29.31  ? 634 TYR A C   1 
ATOM   4605 O O   . TYR A 1 634 ? -25.919 -15.785 9.670   1.00 30.22  ? 634 TYR A O   1 
ATOM   4606 C CB  . TYR A 1 634 ? -28.698 -16.378 8.554   1.00 32.82  ? 634 TYR A CB  1 
ATOM   4607 C CG  . TYR A 1 634 ? -30.223 -16.216 8.581   1.00 39.95  ? 634 TYR A CG  1 
ATOM   4608 C CD1 . TYR A 1 634 ? -30.819 -15.023 8.984   1.00 37.05  ? 634 TYR A CD1 1 
ATOM   4609 C CD2 . TYR A 1 634 ? -31.066 -17.251 8.184   1.00 40.86  ? 634 TYR A CD2 1 
ATOM   4610 C CE1 . TYR A 1 634 ? -32.211 -14.881 9.001   1.00 38.08  ? 634 TYR A CE1 1 
ATOM   4611 C CE2 . TYR A 1 634 ? -32.462 -17.111 8.209   1.00 36.21  ? 634 TYR A CE2 1 
ATOM   4612 C CZ  . TYR A 1 634 ? -33.024 -15.933 8.613   1.00 35.51  ? 634 TYR A CZ  1 
ATOM   4613 O OH  . TYR A 1 634 ? -34.402 -15.808 8.637   1.00 38.55  ? 634 TYR A OH  1 
ATOM   4614 N N   . ILE A 1 635 ? -25.972 -18.038 9.880   1.00 31.37  ? 635 ILE A N   1 
ATOM   4615 C CA  . ILE A 1 635 ? -24.523 -18.225 9.796   1.00 29.67  ? 635 ILE A CA  1 
ATOM   4616 C C   . ILE A 1 635 ? -24.232 -18.979 8.517   1.00 29.11  ? 635 ILE A C   1 
ATOM   4617 O O   . ILE A 1 635 ? -24.829 -20.034 8.269   1.00 29.03  ? 635 ILE A O   1 
ATOM   4618 C CB  . ILE A 1 635 ? -23.961 -18.986 11.009  1.00 29.96  ? 635 ILE A CB  1 
ATOM   4619 C CG1 . ILE A 1 635 ? -24.358 -18.298 12.294  1.00 29.80  ? 635 ILE A CG1 1 
ATOM   4620 C CG2 . ILE A 1 635 ? -22.459 -19.016 10.967  1.00 28.41  ? 635 ILE A CG2 1 
ATOM   4621 C CD1 . ILE A 1 635 ? -24.265 -19.196 13.425  1.00 31.64  ? 635 ILE A CD1 1 
ATOM   4622 N N   . ASP A 1 636 ? -23.320 -18.439 7.707   1.00 27.30  ? 636 ASP A N   1 
ATOM   4623 C CA  . ASP A 1 636 ? -22.982 -19.041 6.426   1.00 26.32  ? 636 ASP A CA  1 
ATOM   4624 C C   . ASP A 1 636 ? -21.645 -19.762 6.448   1.00 31.11  ? 636 ASP A C   1 
ATOM   4625 O O   . ASP A 1 636 ? -21.578 -20.965 6.174   1.00 29.05  ? 636 ASP A O   1 
ATOM   4626 C CB  . ASP A 1 636 ? -22.946 -17.977 5.342   1.00 31.60  ? 636 ASP A CB  1 
ATOM   4627 C CG  . ASP A 1 636 ? -22.240 -18.461 4.094   1.00 39.89  ? 636 ASP A CG  1 
ATOM   4628 O OD1 . ASP A 1 636 ? -22.660 -19.532 3.545   1.00 40.10  ? 636 ASP A OD1 1 
ATOM   4629 O OD2 . ASP A 1 636 ? -21.275 -17.765 3.670   1.00 37.00  ? 636 ASP A OD2 1 
ATOM   4630 N N   . LYS A 1 637 ? -20.570 -19.028 6.736   1.00 31.52  ? 637 LYS A N   1 
ATOM   4631 C CA  . LYS A 1 637 ? -19.228 -19.579 6.714   1.00 30.56  ? 637 LYS A CA  1 
ATOM   4632 C C   . LYS A 1 637 ? -18.430 -19.040 7.868   1.00 28.41  ? 637 LYS A C   1 
ATOM   4633 O O   . LYS A 1 637 ? -18.725 -17.981 8.416   1.00 31.88  ? 637 LYS A O   1 
ATOM   4634 C CB  . LYS A 1 637 ? -18.478 -19.257 5.430   1.00 31.24  ? 637 LYS A CB  1 
ATOM   4635 C CG  . LYS A 1 637 ? -18.757 -20.261 4.363   1.00 33.75  ? 637 LYS A CG  1 
ATOM   4636 C CD  . LYS A 1 637 ? -18.020 -19.935 3.124   1.00 33.29  ? 637 LYS A CD  1 
ATOM   4637 C CE  . LYS A 1 637 ? -18.809 -20.444 1.984   1.00 30.47  ? 637 LYS A CE  1 
ATOM   4638 N NZ  . LYS A 1 637 ? -20.030 -19.593 1.984   1.00 29.00  ? 637 LYS A NZ  1 
ATOM   4639 N N   . ILE A 1 638 ? -17.419 -19.808 8.227   1.00 28.35  ? 638 ILE A N   1 
ATOM   4640 C CA  . ILE A 1 638 ? -16.408 -19.422 9.191   1.00 29.45  ? 638 ILE A CA  1 
ATOM   4641 C C   . ILE A 1 638 ? -15.111 -19.486 8.419   1.00 30.79  ? 638 ILE A C   1 
ATOM   4642 O O   . ILE A 1 638 ? -14.940 -20.364 7.570   1.00 35.53  ? 638 ILE A O   1 
ATOM   4643 C CB  . ILE A 1 638 ? -16.403 -20.361 10.422  1.00 33.70  ? 638 ILE A CB  1 
ATOM   4644 C CG1 . ILE A 1 638 ? -15.607 -19.806 11.573  1.00 26.05  ? 638 ILE A CG1 1 
ATOM   4645 C CG2 . ILE A 1 638 ? -15.801 -21.695 10.097  1.00 43.26  ? 638 ILE A CG2 1 
ATOM   4646 C CD1 . ILE A 1 638 ? -16.424 -18.884 12.365  1.00 41.39  ? 638 ILE A CD1 1 
ATOM   4647 N N   . GLU A 1 639 ? -14.230 -18.536 8.650   1.00 31.44  ? 639 GLU A N   1 
ATOM   4648 C CA  . GLU A 1 639 ? -13.036 -18.404 7.838   1.00 32.53  ? 639 GLU A CA  1 
ATOM   4649 C C   . GLU A 1 639 ? -11.801 -18.505 8.710   1.00 34.78  ? 639 GLU A C   1 
ATOM   4650 O O   . GLU A 1 639 ? -11.807 -18.035 9.849   1.00 39.42  ? 639 GLU A O   1 
ATOM   4651 C CB  . GLU A 1 639 ? -13.040 -17.077 7.117   1.00 35.74  ? 639 GLU A CB  1 
ATOM   4652 C CG  . GLU A 1 639 ? -14.144 -16.975 6.105   1.00 34.77  ? 639 GLU A CG  1 
ATOM   4653 C CD  . GLU A 1 639 ? -13.891 -15.873 5.114   1.00 34.68  ? 639 GLU A CD  1 
ATOM   4654 O OE1 . GLU A 1 639 ? -13.011 -15.014 5.389   1.00 29.07  ? 639 GLU A OE1 1 
ATOM   4655 O OE2 . GLU A 1 639 ? -14.572 -15.884 4.063   1.00 36.41  ? 639 GLU A OE2 1 
ATOM   4656 N N   . PHE A 1 640 ? -10.725 -19.086 8.166   1.00 34.37  ? 640 PHE A N   1 
ATOM   4657 C CA  . PHE A 1 640 ? -9.472  -19.237 8.909   1.00 36.60  ? 640 PHE A CA  1 
ATOM   4658 C C   . PHE A 1 640 ? -8.330  -18.580 8.158   1.00 38.81  ? 640 PHE A C   1 
ATOM   4659 O O   . PHE A 1 640 ? -7.929  -19.065 7.092   1.00 41.84  ? 640 PHE A O   1 
ATOM   4660 C CB  . PHE A 1 640 ? -9.152  -20.702 9.168   1.00 37.47  ? 640 PHE A CB  1 
ATOM   4661 C CG  . PHE A 1 640 ? -10.070 -21.337 10.144  1.00 42.50  ? 640 PHE A CG  1 
ATOM   4662 C CD1 . PHE A 1 640 ? -11.236 -21.965 9.721   1.00 41.34  ? 640 PHE A CD1 1 
ATOM   4663 C CD2 . PHE A 1 640 ? -9.791  -21.269 11.506  1.00 42.90  ? 640 PHE A CD2 1 
ATOM   4664 C CE1 . PHE A 1 640 ? -12.100 -22.542 10.641  1.00 41.34  ? 640 PHE A CE1 1 
ATOM   4665 C CE2 . PHE A 1 640 ? -10.648 -21.839 12.439  1.00 42.53  ? 640 PHE A CE2 1 
ATOM   4666 C CZ  . PHE A 1 640 ? -11.804 -22.475 12.011  1.00 43.76  ? 640 PHE A CZ  1 
ATOM   4667 N N   . ILE A 1 641 ? -7.778  -17.521 8.749   1.00 36.30  ? 641 ILE A N   1 
ATOM   4668 C CA  . ILE A 1 641 ? -6.702  -16.741 8.146   1.00 38.80  ? 641 ILE A CA  1 
ATOM   4669 C C   . ILE A 1 641 ? -5.400  -17.149 8.837   1.00 40.62  ? 641 ILE A C   1 
ATOM   4670 O O   . ILE A 1 641 ? -5.235  -16.858 10.032  1.00 38.31  ? 641 ILE A O   1 
ATOM   4671 C CB  . ILE A 1 641 ? -6.928  -15.237 8.320   1.00 39.13  ? 641 ILE A CB  1 
ATOM   4672 C CG1 . ILE A 1 641 ? -8.152  -14.760 7.590   1.00 31.16  ? 641 ILE A CG1 1 
ATOM   4673 C CG2 . ILE A 1 641 ? -5.791  -14.472 7.696   1.00 40.09  ? 641 ILE A CG2 1 
ATOM   4674 C CD1 . ILE A 1 641 ? -8.665  -13.561 8.248   1.00 30.13  ? 641 ILE A CD1 1 
ATOM   4675 N N   . PRO A 1 642 ? -4.473  -17.800 8.148   1.00 42.91  ? 642 PRO A N   1 
ATOM   4676 C CA  . PRO A 1 642 ? -3.228  -18.194 8.814   1.00 46.59  ? 642 PRO A CA  1 
ATOM   4677 C C   . PRO A 1 642 ? -2.347  -16.978 9.064   1.00 48.15  ? 642 PRO A C   1 
ATOM   4678 O O   . PRO A 1 642 ? -2.217  -16.094 8.213   1.00 47.60  ? 642 PRO A O   1 
ATOM   4679 C CB  . PRO A 1 642 ? -2.596  -19.186 7.832   1.00 45.35  ? 642 PRO A CB  1 
ATOM   4680 C CG  . PRO A 1 642 ? -3.220  -18.894 6.504   1.00 42.97  ? 642 PRO A CG  1 
ATOM   4681 C CD  . PRO A 1 642 ? -4.559  -18.265 6.753   1.00 40.04  ? 642 PRO A CD  1 
ATOM   4682 N N   . VAL A 1 643 ? -1.746  -16.948 10.251  1.00 49.81  ? 643 VAL A N   1 
ATOM   4683 C CA  . VAL A 1 643 ? -1.171  -15.755 10.864  1.00 59.05  ? 643 VAL A CA  1 
ATOM   4684 C C   . VAL A 1 643 ? 0.248   -16.109 11.309  1.00 64.64  ? 643 VAL A C   1 
ATOM   4685 O O   . VAL A 1 643 ? 0.696   -17.238 11.114  1.00 68.54  ? 643 VAL A O   1 
ATOM   4686 C CB  . VAL A 1 643 ? -2.075  -15.237 12.019  1.00 57.78  ? 643 VAL A CB  1 
ATOM   4687 C CG1 . VAL A 1 643 ? -1.415  -14.288 12.988  1.00 68.99  ? 643 VAL A CG1 1 
ATOM   4688 C CG2 . VAL A 1 643 ? -3.274  -14.519 11.427  1.00 52.49  ? 643 VAL A CG2 1 
ATOM   4689 N N   . ASN A 1 644 ? 0.990   -15.126 11.827  1.00 68.32  ? 644 ASN A N   1 
ATOM   4690 C CA  . ASN A 1 644 ? 2.278   -15.404 12.490  1.00 89.87  ? 644 ASN A CA  1 
ATOM   4691 C C   . ASN A 1 644 ? 2.251   -15.117 14.032  1.00 99.24  ? 644 ASN A C   1 
ATOM   4692 O O   . ASN A 1 644 ? 1.230   -14.718 14.625  1.00 93.30  ? 644 ASN A O   1 
ATOM   4693 C CB  . ASN A 1 644 ? 3.422   -14.621 11.798  1.00 82.81  ? 644 ASN A CB  1 
ATOM   4694 C CG  . ASN A 1 644 ? 3.515   -14.909 10.286  1.00 82.28  ? 644 ASN A CG  1 
ATOM   4695 O OD1 . ASN A 1 644 ? 3.276   -16.033 9.836   1.00 84.36  ? 644 ASN A OD1 1 
ATOM   4696 N ND2 . ASN A 1 644 ? 3.875   -13.891 9.505   1.00 72.65  ? 644 ASN A ND2 1 
ATOM   4697 O OXT . ASN A 1 644 ? 3.250   -15.319 14.756  1.00 98.08  ? 644 ASN A OXT 1 
HETATM 4698 O O   . HOH B 2 .   ? -52.855 -51.967 -19.511 1.00 47.75  ? 701 HOH A O   1 
HETATM 4699 O O   . HOH B 2 .   ? -48.818 -29.690 -8.907  1.00 46.89  ? 702 HOH A O   1 
HETATM 4700 O O   . HOH B 2 .   ? -20.364 -10.249 2.047   1.00 31.20  ? 703 HOH A O   1 
HETATM 4701 O O   . HOH B 2 .   ? -37.397 -12.713 -7.476  1.00 33.93  ? 704 HOH A O   1 
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