data_8YQB
# 
_entry.id   8YQB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YQB         pdb_00008yqb 10.2210/pdb8yqb/pdb 
WWPDB D_1300046156 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YQB 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              sujy100@nenu.edu.cn 
_pdbx_contact_author.name_first         Jiyong 
_pdbx_contact_author.name_last          Su 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8406-1676 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Su, J.Y.'  1 ? 
'Sun, Y.Q.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Galectin-10 N32A' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Su, J.Y.'  1 ? 
primary 'Sun, Y.Q.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Galectin-10 16428.809 1   ? N32A ? ? 
2 water   nat water       18.015    172 ? ?    ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Gal-10,Charcot-Leyden crystal protein,CLC,Eosinophil lysophospholipase,Lysolecithin acylhydrolase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSLLPVPYTEAASLSTGSTVTIKGRPLACFLAEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKN
MPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSLLPVPYTEAASLSTGSTVTIKGRPLACFLAEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKN
MPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   LEU n 
1 4   LEU n 
1 5   PRO n 
1 6   VAL n 
1 7   PRO n 
1 8   TYR n 
1 9   THR n 
1 10  GLU n 
1 11  ALA n 
1 12  ALA n 
1 13  SER n 
1 14  LEU n 
1 15  SER n 
1 16  THR n 
1 17  GLY n 
1 18  SER n 
1 19  THR n 
1 20  VAL n 
1 21  THR n 
1 22  ILE n 
1 23  LYS n 
1 24  GLY n 
1 25  ARG n 
1 26  PRO n 
1 27  LEU n 
1 28  ALA n 
1 29  CYS n 
1 30  PHE n 
1 31  LEU n 
1 32  ALA n 
1 33  GLU n 
1 34  PRO n 
1 35  TYR n 
1 36  LEU n 
1 37  GLN n 
1 38  VAL n 
1 39  ASP n 
1 40  PHE n 
1 41  HIS n 
1 42  THR n 
1 43  GLU n 
1 44  MET n 
1 45  LYS n 
1 46  GLU n 
1 47  GLU n 
1 48  SER n 
1 49  ASP n 
1 50  ILE n 
1 51  VAL n 
1 52  PHE n 
1 53  HIS n 
1 54  PHE n 
1 55  GLN n 
1 56  VAL n 
1 57  CYS n 
1 58  PHE n 
1 59  GLY n 
1 60  ARG n 
1 61  ARG n 
1 62  VAL n 
1 63  VAL n 
1 64  MET n 
1 65  ASN n 
1 66  SER n 
1 67  ARG n 
1 68  GLU n 
1 69  TYR n 
1 70  GLY n 
1 71  ALA n 
1 72  TRP n 
1 73  LYS n 
1 74  GLN n 
1 75  GLN n 
1 76  VAL n 
1 77  GLU n 
1 78  SER n 
1 79  LYS n 
1 80  ASN n 
1 81  MET n 
1 82  PRO n 
1 83  PHE n 
1 84  GLN n 
1 85  ASP n 
1 86  GLY n 
1 87  GLN n 
1 88  GLU n 
1 89  PHE n 
1 90  GLU n 
1 91  LEU n 
1 92  SER n 
1 93  ILE n 
1 94  SER n 
1 95  VAL n 
1 96  LEU n 
1 97  PRO n 
1 98  ASP n 
1 99  LYS n 
1 100 TYR n 
1 101 GLN n 
1 102 VAL n 
1 103 MET n 
1 104 VAL n 
1 105 ASN n 
1 106 GLY n 
1 107 GLN n 
1 108 SER n 
1 109 SER n 
1 110 TYR n 
1 111 THR n 
1 112 PHE n 
1 113 ASP n 
1 114 HIS n 
1 115 ARG n 
1 116 ILE n 
1 117 LYS n 
1 118 PRO n 
1 119 GLU n 
1 120 ALA n 
1 121 VAL n 
1 122 LYS n 
1 123 MET n 
1 124 VAL n 
1 125 GLN n 
1 126 VAL n 
1 127 TRP n 
1 128 ARG n 
1 129 ASP n 
1 130 ILE n 
1 131 SER n 
1 132 LEU n 
1 133 THR n 
1 134 LYS n 
1 135 PHE n 
1 136 ASN n 
1 137 VAL n 
1 138 SER n 
1 139 TYR n 
1 140 LEU n 
1 141 LYS n 
1 142 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   142 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'CLC, LGALS10, LGALS10A' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   LEU 3   3   ?   ?   ?   A . n 
A 1 4   LEU 4   4   4   LEU LEU A . n 
A 1 5   PRO 5   5   5   PRO PRO A . n 
A 1 6   VAL 6   6   6   VAL VAL A . n 
A 1 7   PRO 7   7   7   PRO PRO A . n 
A 1 8   TYR 8   8   8   TYR TYR A . n 
A 1 9   THR 9   9   9   THR THR A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  ALA 12  12  12  ALA ALA A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  LEU 14  14  14  LEU LEU A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  THR 16  16  16  THR THR A . n 
A 1 17  GLY 17  17  17  GLY GLY A . n 
A 1 18  SER 18  18  18  SER SER A . n 
A 1 19  THR 19  19  19  THR THR A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  ILE 22  22  22  ILE ILE A . n 
A 1 23  LYS 23  23  23  LYS LYS A . n 
A 1 24  GLY 24  24  24  GLY GLY A . n 
A 1 25  ARG 25  25  25  ARG ARG A . n 
A 1 26  PRO 26  26  26  PRO PRO A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ALA 28  28  28  ALA ALA A . n 
A 1 29  CYS 29  29  29  CYS CYS A . n 
A 1 30  PHE 30  30  30  PHE PHE A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  GLU 33  33  33  GLU GLU A . n 
A 1 34  PRO 34  34  34  PRO PRO A . n 
A 1 35  TYR 35  35  35  TYR TYR A . n 
A 1 36  LEU 36  36  36  LEU LEU A . n 
A 1 37  GLN 37  37  37  GLN GLN A . n 
A 1 38  VAL 38  38  38  VAL VAL A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
A 1 40  PHE 40  40  40  PHE PHE A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  THR 42  42  42  THR THR A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  MET 44  44  44  MET MET A . n 
A 1 45  LYS 45  45  45  LYS LYS A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  SER 48  48  48  SER SER A . n 
A 1 49  ASP 49  49  49  ASP ASP A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  HIS 53  53  53  HIS HIS A . n 
A 1 54  PHE 54  54  54  PHE PHE A . n 
A 1 55  GLN 55  55  55  GLN GLN A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  CYS 57  57  57  CYS CYS A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  ARG 61  61  61  ARG ARG A . n 
A 1 62  VAL 62  62  62  VAL VAL A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  MET 64  64  64  MET MET A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  SER 66  66  66  SER SER A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  GLU 68  68  68  GLU GLU A . n 
A 1 69  TYR 69  69  69  TYR TYR A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  ALA 71  71  71  ALA ALA A . n 
A 1 72  TRP 72  72  72  TRP TRP A . n 
A 1 73  LYS 73  73  73  LYS LYS A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  GLN 75  75  75  GLN GLN A . n 
A 1 76  VAL 76  76  76  VAL VAL A . n 
A 1 77  GLU 77  77  77  GLU GLU A . n 
A 1 78  SER 78  78  78  SER SER A . n 
A 1 79  LYS 79  79  79  LYS LYS A . n 
A 1 80  ASN 80  80  80  ASN ASN A . n 
A 1 81  MET 81  81  81  MET MET A . n 
A 1 82  PRO 82  82  82  PRO PRO A . n 
A 1 83  PHE 83  83  83  PHE PHE A . n 
A 1 84  GLN 84  84  84  GLN GLN A . n 
A 1 85  ASP 85  85  85  ASP ASP A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  GLN 87  87  87  GLN GLN A . n 
A 1 88  GLU 88  88  88  GLU GLU A . n 
A 1 89  PHE 89  89  89  PHE PHE A . n 
A 1 90  GLU 90  90  90  GLU GLU A . n 
A 1 91  LEU 91  91  91  LEU LEU A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  ILE 93  93  93  ILE ILE A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  PRO 97  97  97  PRO PRO A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 TYR 100 100 100 TYR TYR A . n 
A 1 101 GLN 101 101 101 GLN GLN A . n 
A 1 102 VAL 102 102 102 VAL VAL A . n 
A 1 103 MET 103 103 103 MET MET A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ASN 105 105 105 ASN ASN A . n 
A 1 106 GLY 106 106 106 GLY GLY A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 SER 108 108 108 SER SER A . n 
A 1 109 SER 109 109 109 SER SER A . n 
A 1 110 TYR 110 110 110 TYR TYR A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 ASP 113 113 113 ASP ASP A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 LYS 117 117 117 LYS LYS A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 ALA 120 120 120 ALA ALA A . n 
A 1 121 VAL 121 121 121 VAL VAL A . n 
A 1 122 LYS 122 122 122 LYS LYS A . n 
A 1 123 MET 123 123 123 MET MET A . n 
A 1 124 VAL 124 124 124 VAL VAL A . n 
A 1 125 GLN 125 125 125 GLN GLN A . n 
A 1 126 VAL 126 126 126 VAL VAL A . n 
A 1 127 TRP 127 127 127 TRP TRP A . n 
A 1 128 ARG 128 128 128 ARG ARG A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 ILE 130 130 130 ILE ILE A . n 
A 1 131 SER 131 131 131 SER SER A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 THR 133 133 133 THR THR A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 ASN 136 136 136 ASN ASN A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 SER 138 138 138 SER SER A . n 
A 1 139 TYR 139 139 139 TYR TYR A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 ARG 142 142 142 ARG ARG A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   201 98  HOH HOH A . 
B 2 HOH 2   202 15  HOH HOH A . 
B 2 HOH 3   203 73  HOH HOH A . 
B 2 HOH 4   204 59  HOH HOH A . 
B 2 HOH 5   205 48  HOH HOH A . 
B 2 HOH 6   206 26  HOH HOH A . 
B 2 HOH 7   207 1   HOH HOH A . 
B 2 HOH 8   208 101 HOH HOH A . 
B 2 HOH 9   209 168 HOH HOH A . 
B 2 HOH 10  210 70  HOH HOH A . 
B 2 HOH 11  211 11  HOH HOH A . 
B 2 HOH 12  212 137 HOH HOH A . 
B 2 HOH 13  213 12  HOH HOH A . 
B 2 HOH 14  214 144 HOH HOH A . 
B 2 HOH 15  215 117 HOH HOH A . 
B 2 HOH 16  216 16  HOH HOH A . 
B 2 HOH 17  217 51  HOH HOH A . 
B 2 HOH 18  218 49  HOH HOH A . 
B 2 HOH 19  219 62  HOH HOH A . 
B 2 HOH 20  220 9   HOH HOH A . 
B 2 HOH 21  221 30  HOH HOH A . 
B 2 HOH 22  222 53  HOH HOH A . 
B 2 HOH 23  223 6   HOH HOH A . 
B 2 HOH 24  224 41  HOH HOH A . 
B 2 HOH 25  225 33  HOH HOH A . 
B 2 HOH 26  226 19  HOH HOH A . 
B 2 HOH 27  227 139 HOH HOH A . 
B 2 HOH 28  228 10  HOH HOH A . 
B 2 HOH 29  229 109 HOH HOH A . 
B 2 HOH 30  230 78  HOH HOH A . 
B 2 HOH 31  231 104 HOH HOH A . 
B 2 HOH 32  232 8   HOH HOH A . 
B 2 HOH 33  233 29  HOH HOH A . 
B 2 HOH 34  234 32  HOH HOH A . 
B 2 HOH 35  235 85  HOH HOH A . 
B 2 HOH 36  236 132 HOH HOH A . 
B 2 HOH 37  237 133 HOH HOH A . 
B 2 HOH 38  238 39  HOH HOH A . 
B 2 HOH 39  239 42  HOH HOH A . 
B 2 HOH 40  240 43  HOH HOH A . 
B 2 HOH 41  241 2   HOH HOH A . 
B 2 HOH 42  242 55  HOH HOH A . 
B 2 HOH 43  243 28  HOH HOH A . 
B 2 HOH 44  244 17  HOH HOH A . 
B 2 HOH 45  245 24  HOH HOH A . 
B 2 HOH 46  246 134 HOH HOH A . 
B 2 HOH 47  247 68  HOH HOH A . 
B 2 HOH 48  248 146 HOH HOH A . 
B 2 HOH 49  249 13  HOH HOH A . 
B 2 HOH 50  250 114 HOH HOH A . 
B 2 HOH 51  251 72  HOH HOH A . 
B 2 HOH 52  252 60  HOH HOH A . 
B 2 HOH 53  253 69  HOH HOH A . 
B 2 HOH 54  254 91  HOH HOH A . 
B 2 HOH 55  255 45  HOH HOH A . 
B 2 HOH 56  256 64  HOH HOH A . 
B 2 HOH 57  257 82  HOH HOH A . 
B 2 HOH 58  258 5   HOH HOH A . 
B 2 HOH 59  259 3   HOH HOH A . 
B 2 HOH 60  260 80  HOH HOH A . 
B 2 HOH 61  261 27  HOH HOH A . 
B 2 HOH 62  262 94  HOH HOH A . 
B 2 HOH 63  263 22  HOH HOH A . 
B 2 HOH 64  264 81  HOH HOH A . 
B 2 HOH 65  265 153 HOH HOH A . 
B 2 HOH 66  266 36  HOH HOH A . 
B 2 HOH 67  267 46  HOH HOH A . 
B 2 HOH 68  268 67  HOH HOH A . 
B 2 HOH 69  269 37  HOH HOH A . 
B 2 HOH 70  270 159 HOH HOH A . 
B 2 HOH 71  271 86  HOH HOH A . 
B 2 HOH 72  272 145 HOH HOH A . 
B 2 HOH 73  273 89  HOH HOH A . 
B 2 HOH 74  274 103 HOH HOH A . 
B 2 HOH 75  275 14  HOH HOH A . 
B 2 HOH 76  276 25  HOH HOH A . 
B 2 HOH 77  277 7   HOH HOH A . 
B 2 HOH 78  278 126 HOH HOH A . 
B 2 HOH 79  279 61  HOH HOH A . 
B 2 HOH 80  280 47  HOH HOH A . 
B 2 HOH 81  281 54  HOH HOH A . 
B 2 HOH 82  282 50  HOH HOH A . 
B 2 HOH 83  283 142 HOH HOH A . 
B 2 HOH 84  284 178 HOH HOH A . 
B 2 HOH 85  285 38  HOH HOH A . 
B 2 HOH 86  286 105 HOH HOH A . 
B 2 HOH 87  287 57  HOH HOH A . 
B 2 HOH 88  288 130 HOH HOH A . 
B 2 HOH 89  289 75  HOH HOH A . 
B 2 HOH 90  290 83  HOH HOH A . 
B 2 HOH 91  291 166 HOH HOH A . 
B 2 HOH 92  292 35  HOH HOH A . 
B 2 HOH 93  293 92  HOH HOH A . 
B 2 HOH 94  294 63  HOH HOH A . 
B 2 HOH 95  295 155 HOH HOH A . 
B 2 HOH 96  296 143 HOH HOH A . 
B 2 HOH 97  297 88  HOH HOH A . 
B 2 HOH 98  298 111 HOH HOH A . 
B 2 HOH 99  299 34  HOH HOH A . 
B 2 HOH 100 300 79  HOH HOH A . 
B 2 HOH 101 301 21  HOH HOH A . 
B 2 HOH 102 302 96  HOH HOH A . 
B 2 HOH 103 303 93  HOH HOH A . 
B 2 HOH 104 304 123 HOH HOH A . 
B 2 HOH 105 305 71  HOH HOH A . 
B 2 HOH 106 306 44  HOH HOH A . 
B 2 HOH 107 307 172 HOH HOH A . 
B 2 HOH 108 308 65  HOH HOH A . 
B 2 HOH 109 309 108 HOH HOH A . 
B 2 HOH 110 310 140 HOH HOH A . 
B 2 HOH 111 311 84  HOH HOH A . 
B 2 HOH 112 312 102 HOH HOH A . 
B 2 HOH 113 313 87  HOH HOH A . 
B 2 HOH 114 314 107 HOH HOH A . 
B 2 HOH 115 315 23  HOH HOH A . 
B 2 HOH 116 316 165 HOH HOH A . 
B 2 HOH 117 317 20  HOH HOH A . 
B 2 HOH 118 318 179 HOH HOH A . 
B 2 HOH 119 319 148 HOH HOH A . 
B 2 HOH 120 320 171 HOH HOH A . 
B 2 HOH 121 321 4   HOH HOH A . 
B 2 HOH 122 322 174 HOH HOH A . 
B 2 HOH 123 323 56  HOH HOH A . 
B 2 HOH 124 324 120 HOH HOH A . 
B 2 HOH 125 325 121 HOH HOH A . 
B 2 HOH 126 326 118 HOH HOH A . 
B 2 HOH 127 327 147 HOH HOH A . 
B 2 HOH 128 328 52  HOH HOH A . 
B 2 HOH 129 329 158 HOH HOH A . 
B 2 HOH 130 330 76  HOH HOH A . 
B 2 HOH 131 331 175 HOH HOH A . 
B 2 HOH 132 332 156 HOH HOH A . 
B 2 HOH 133 333 116 HOH HOH A . 
B 2 HOH 134 334 58  HOH HOH A . 
B 2 HOH 135 335 160 HOH HOH A . 
B 2 HOH 136 336 151 HOH HOH A . 
B 2 HOH 137 337 110 HOH HOH A . 
B 2 HOH 138 338 152 HOH HOH A . 
B 2 HOH 139 339 90  HOH HOH A . 
B 2 HOH 140 340 154 HOH HOH A . 
B 2 HOH 141 341 131 HOH HOH A . 
B 2 HOH 142 342 141 HOH HOH A . 
B 2 HOH 143 343 164 HOH HOH A . 
B 2 HOH 144 344 40  HOH HOH A . 
B 2 HOH 145 345 100 HOH HOH A . 
B 2 HOH 146 346 136 HOH HOH A . 
B 2 HOH 147 347 176 HOH HOH A . 
B 2 HOH 148 348 169 HOH HOH A . 
B 2 HOH 149 349 119 HOH HOH A . 
B 2 HOH 150 350 122 HOH HOH A . 
B 2 HOH 151 351 112 HOH HOH A . 
B 2 HOH 152 352 173 HOH HOH A . 
B 2 HOH 153 353 66  HOH HOH A . 
B 2 HOH 154 354 170 HOH HOH A . 
B 2 HOH 155 355 113 HOH HOH A . 
B 2 HOH 156 356 124 HOH HOH A . 
B 2 HOH 157 357 135 HOH HOH A . 
B 2 HOH 158 358 74  HOH HOH A . 
B 2 HOH 159 359 127 HOH HOH A . 
B 2 HOH 160 360 157 HOH HOH A . 
B 2 HOH 161 361 97  HOH HOH A . 
B 2 HOH 162 362 18  HOH HOH A . 
B 2 HOH 163 363 149 HOH HOH A . 
B 2 HOH 164 364 95  HOH HOH A . 
B 2 HOH 165 365 177 HOH HOH A . 
B 2 HOH 166 366 163 HOH HOH A . 
B 2 HOH 167 367 115 HOH HOH A . 
B 2 HOH 168 368 161 HOH HOH A . 
B 2 HOH 169 369 150 HOH HOH A . 
B 2 HOH 170 370 167 HOH HOH A . 
B 2 HOH 171 371 99  HOH HOH A . 
B 2 HOH 172 372 106 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 45 ? CG  ? A LYS 45 CG  
2  1 Y 1 A LYS 45 ? CD  ? A LYS 45 CD  
3  1 Y 1 A LYS 45 ? CE  ? A LYS 45 CE  
4  1 Y 1 A LYS 45 ? NZ  ? A LYS 45 NZ  
5  1 Y 1 A ARG 60 ? CG  ? A ARG 60 CG  
6  1 Y 1 A ARG 60 ? CD  ? A ARG 60 CD  
7  1 Y 1 A ARG 60 ? NE  ? A ARG 60 NE  
8  1 Y 1 A ARG 60 ? CZ  ? A ARG 60 CZ  
9  1 Y 1 A ARG 60 ? NH1 ? A ARG 60 NH1 
10 1 Y 1 A ARG 60 ? NH2 ? A ARG 60 NH2 
# 
_software.citation_id            ? 
_software.classification         refinement 
_software.compiler_name          ? 
_software.compiler_version       ? 
_software.contact_author         ? 
_software.contact_author_email   ? 
_software.date                   ? 
_software.description            ? 
_software.dependencies           ? 
_software.hardware               ? 
_software.language               ? 
_software.location               ? 
_software.mods                   ? 
_software.name                   PHENIX 
_software.os                     ? 
_software.os_version             ? 
_software.type                   ? 
_software.version                '(1.18.2_3874: ???)' 
_software.pdbx_ordinal           1 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YQB 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     48.981 
_cell.length_a_esd                 ? 
_cell.length_b                     48.981 
_cell.length_b_esd                 ? 
_cell.length_c                     263.283 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YQB 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                179 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 65 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YQB 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.77 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.67 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    PEG 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97853 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL18U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97853 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL18U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YQB 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.95 
_reflns.d_resolution_low                               19.67 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     14787 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.142 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.95 
_reflns_shell.d_res_low                                     2.00 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             987 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.6 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YQB 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.95 
_refine.ls_d_res_low                             19.67 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     14681 
_refine.ls_number_reflns_R_free                  1468 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.95 
_refine.ls_percent_reflns_R_free                 10.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1942 
_refine.ls_R_factor_R_free                       0.2187 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1915 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.35 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.18 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.95 
_refine_hist.d_res_low                        19.67 
_refine_hist.number_atoms_solvent             172 
_refine_hist.number_atoms_total               1293 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1121 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  ? 1163 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.179  ? 1575 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 21.696 ? 152  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.072  ? 172  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.006  ? 202  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.95 2.02  . . 142 1276 100.00 . . . . 0.2148 . . . . . . . . . . . 0.2753 
'X-RAY DIFFRACTION' 2.02 2.10  . . 140 1263 100.00 . . . . 0.1918 . . . . . . . . . . . 0.2442 
'X-RAY DIFFRACTION' 2.10 2.20  . . 142 1281 100.00 . . . . 0.2009 . . . . . . . . . . . 0.2228 
'X-RAY DIFFRACTION' 2.20 2.31  . . 144 1297 100.00 . . . . 0.1921 . . . . . . . . . . . 0.2231 
'X-RAY DIFFRACTION' 2.31 2.46  . . 146 1300 100.00 . . . . 0.1941 . . . . . . . . . . . 0.2268 
'X-RAY DIFFRACTION' 2.46 2.65  . . 142 1285 100.00 . . . . 0.2055 . . . . . . . . . . . 0.2513 
'X-RAY DIFFRACTION' 2.65 2.91  . . 145 1320 100.00 . . . . 0.1943 . . . . . . . . . . . 0.2239 
'X-RAY DIFFRACTION' 2.91 3.33  . . 149 1333 100.00 . . . . 0.1891 . . . . . . . . . . . 0.2360 
'X-RAY DIFFRACTION' 3.33 4.19  . . 152 1370 100.00 . . . . 0.1829 . . . . . . . . . . . 0.1971 
'X-RAY DIFFRACTION' 4.19 19.67 . . 166 1488 100.00 . . . . 0.1856 . . . . . . . . . . . 0.1891 
# 
_struct.entry_id                     8YQB 
_struct.title                        'Galectin-10 N32A' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YQB 
_struct_keywords.text            'Galectin-10 N32A, SUGAR BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'SUGAR BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    LEG10_HUMAN 
_struct_ref.pdbx_db_accession          Q05315 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKN
MPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YQB 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 142 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q05315 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  142 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       142 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8YQB 
_struct_ref_seq_dif.mon_id                       ALA 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      32 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q05315 
_struct_ref_seq_dif.db_mon_id                    ASN 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          32 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            32 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555  x,y,z        1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 10_555 -y,-x,-z+1/6 0.5000000000 -0.8660254038 0.0000000000 0.0000000000 -0.8660254038 
-0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 43.8805000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 CYS A 29  ? GLU A 33  ? CYS A 29  GLU A 33  5 ? 5 
HELX_P HELX_P2 AA2 LYS A 117 ? VAL A 121 ? LYS A 117 VAL A 121 5 ? 5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          VAL 
_struct_mon_prot_cis.label_seq_id           6 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           VAL 
_struct_mon_prot_cis.auth_seq_id            6 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    7 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     7 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       2.43 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 6 ? 
AA3 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 8   ? ALA A 11  ? TYR A 8   ALA A 11  
AA1 2 MET A 123 ? ARG A 128 ? MET A 123 ARG A 128 
AA1 3 TYR A 35  ? HIS A 41  ? TYR A 35  HIS A 41  
AA1 4 ILE A 50  ? CYS A 57  ? ILE A 50  CYS A 57  
AA1 5 ARG A 61  ? GLU A 68  ? ARG A 61  GLU A 68  
AA1 6 ALA A 71  ? TRP A 72  ? ALA A 71  TRP A 72  
AA2 1 TYR A 8   ? ALA A 11  ? TYR A 8   ALA A 11  
AA2 2 MET A 123 ? ARG A 128 ? MET A 123 ARG A 128 
AA2 3 TYR A 35  ? HIS A 41  ? TYR A 35  HIS A 41  
AA2 4 ILE A 50  ? CYS A 57  ? ILE A 50  CYS A 57  
AA2 5 ARG A 61  ? GLU A 68  ? ARG A 61  GLU A 68  
AA2 6 VAL A 76  ? SER A 78  ? VAL A 76  SER A 78  
AA3 1 GLN A 107 ? ASP A 113 ? GLN A 107 ASP A 113 
AA3 2 LYS A 99  ? VAL A 104 ? LYS A 99  VAL A 104 
AA3 3 PHE A 89  ? VAL A 95  ? PHE A 89  VAL A 95  
AA3 4 THR A 19  ? PRO A 26  ? THR A 19  PRO A 26  
AA3 5 ILE A 130 ? VAL A 137 ? ILE A 130 VAL A 137 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 8   ? N TYR A 8   O VAL A 126 ? O VAL A 126 
AA1 2 3 O MET A 123 ? O MET A 123 N HIS A 41  ? N HIS A 41  
AA1 3 4 N LEU A 36  ? N LEU A 36  O VAL A 56  ? O VAL A 56  
AA1 4 5 N CYS A 57  ? N CYS A 57  O ARG A 61  ? O ARG A 61  
AA1 5 6 N GLU A 68  ? N GLU A 68  O ALA A 71  ? O ALA A 71  
AA2 1 2 N TYR A 8   ? N TYR A 8   O VAL A 126 ? O VAL A 126 
AA2 2 3 O MET A 123 ? O MET A 123 N HIS A 41  ? N HIS A 41  
AA2 3 4 N LEU A 36  ? N LEU A 36  O VAL A 56  ? O VAL A 56  
AA2 4 5 N CYS A 57  ? N CYS A 57  O ARG A 61  ? O ARG A 61  
AA2 5 6 N VAL A 62  ? N VAL A 62  O SER A 78  ? O SER A 78  
AA3 1 2 O TYR A 110 ? O TYR A 110 N VAL A 102 ? N VAL A 102 
AA3 2 3 O MET A 103 ? O MET A 103 N SER A 92  ? N SER A 92  
AA3 3 4 O LEU A 91  ? O LEU A 91  N ILE A 22  ? N ILE A 22  
AA3 4 5 N THR A 21  ? N THR A 21  O ASN A 136 ? O ASN A 136 
# 
_pdbx_entry_details.entry_id                   8YQB 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 25  ? ? -172.05 119.02  
2 1 ARG A 60  ? ? -124.09 -68.71  
3 1 LYS A 73  ? ? -101.74 -150.74 
4 1 SER A 109 ? ? -131.59 -30.41  
5 1 ARG A 128 ? ? 80.01   -148.42 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 279 ? B HOH . 
2 1 A HOH 292 ? B HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 371 ? 6.21 . 
2 1 O ? A HOH 372 ? 6.64 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1 ? A MET 1 
2 1 Y 1 A SER 2 ? A SER 2 
3 1 Y 1 A LEU 3 ? A LEU 3 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32171255 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5XRG 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YQB 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020416 
_atom_sites.fract_transf_matrix[1][2]   0.011787 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.023574 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003798 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LEU A 1 4   ? 37.404 -26.502 14.650  1.00 37.27 ? 4   LEU A N   1 
ATOM   2    C CA  . LEU A 1 4   ? 37.543 -25.225 13.953  1.00 31.25 ? 4   LEU A CA  1 
ATOM   3    C C   . LEU A 1 4   ? 37.400 -24.080 14.956  1.00 30.19 ? 4   LEU A C   1 
ATOM   4    O O   . LEU A 1 4   ? 36.579 -24.160 15.869  1.00 29.27 ? 4   LEU A O   1 
ATOM   5    C CB  . LEU A 1 4   ? 36.484 -25.104 12.858  1.00 27.03 ? 4   LEU A CB  1 
ATOM   6    C CG  . LEU A 1 4   ? 36.772 -25.901 11.574  1.00 31.47 ? 4   LEU A CG  1 
ATOM   7    C CD1 . LEU A 1 4   ? 36.621 -27.397 11.809  1.00 35.10 ? 4   LEU A CD1 1 
ATOM   8    C CD2 . LEU A 1 4   ? 35.813 -25.500 10.461  1.00 28.55 ? 4   LEU A CD2 1 
ATOM   9    N N   . PRO A 1 5   ? 38.204 -23.025 14.855  1.00 28.21 ? 5   PRO A N   1 
ATOM   10   C CA  . PRO A 1 5   ? 38.115 -21.945 15.851  1.00 23.00 ? 5   PRO A CA  1 
ATOM   11   C C   . PRO A 1 5   ? 36.847 -21.141 15.643  1.00 23.05 ? 5   PRO A C   1 
ATOM   12   O O   . PRO A 1 5   ? 36.440 -20.875 14.510  1.00 24.27 ? 5   PRO A O   1 
ATOM   13   C CB  . PRO A 1 5   ? 39.352 -21.083 15.590  1.00 29.48 ? 5   PRO A CB  1 
ATOM   14   C CG  . PRO A 1 5   ? 39.937 -21.563 14.301  1.00 32.01 ? 5   PRO A CG  1 
ATOM   15   C CD  . PRO A 1 5   ? 39.256 -22.806 13.850  1.00 30.91 ? 5   PRO A CD  1 
ATOM   16   N N   . VAL A 1 6   ? 36.208 -20.775 16.745  1.00 17.21 ? 6   VAL A N   1 
ATOM   17   C CA  . VAL A 1 6   ? 35.037 -19.903 16.693  1.00 20.26 ? 6   VAL A CA  1 
ATOM   18   C C   . VAL A 1 6   ? 35.319 -18.686 17.571  1.00 20.25 ? 6   VAL A C   1 
ATOM   19   O O   . VAL A 1 6   ? 35.699 -18.858 18.740  1.00 15.61 ? 6   VAL A O   1 
ATOM   20   C CB  . VAL A 1 6   ? 33.766 -20.643 17.138  1.00 17.99 ? 6   VAL A CB  1 
ATOM   21   C CG1 . VAL A 1 6   ? 32.562 -19.689 17.134  1.00 16.29 ? 6   VAL A CG1 1 
ATOM   22   C CG2 . VAL A 1 6   ? 33.503 -21.843 16.225  1.00 18.21 ? 6   VAL A CG2 1 
ATOM   23   N N   . PRO A 1 7   ? 35.137 -17.442 17.076  1.00 18.74 ? 7   PRO A N   1 
ATOM   24   C CA  . PRO A 1 7   ? 34.635 -17.022 15.755  1.00 15.71 ? 7   PRO A CA  1 
ATOM   25   C C   . PRO A 1 7   ? 35.492 -17.535 14.608  1.00 19.87 ? 7   PRO A C   1 
ATOM   26   O O   . PRO A 1 7   ? 36.720 -17.556 14.695  1.00 18.87 ? 7   PRO A O   1 
ATOM   27   C CB  . PRO A 1 7   ? 34.702 -15.493 15.816  1.00 18.33 ? 7   PRO A CB  1 
ATOM   28   C CG  . PRO A 1 7   ? 34.591 -15.177 17.290  1.00 20.01 ? 7   PRO A CG  1 
ATOM   29   C CD  . PRO A 1 7   ? 35.366 -16.282 17.962  1.00 19.97 ? 7   PRO A CD  1 
ATOM   30   N N   . TYR A 1 8   ? 34.834 -17.979 13.555  1.00 13.37 ? 8   TYR A N   1 
ATOM   31   C CA  . TYR A 1 8   ? 35.500 -18.543 12.395  1.00 14.38 ? 8   TYR A CA  1 
ATOM   32   C C   . TYR A 1 8   ? 35.382 -17.573 11.229  1.00 17.07 ? 8   TYR A C   1 
ATOM   33   O O   . TYR A 1 8   ? 34.276 -17.135 10.900  1.00 12.73 ? 8   TYR A O   1 
ATOM   34   C CB  . TYR A 1 8   ? 34.872 -19.876 12.008  1.00 15.62 ? 8   TYR A CB  1 
ATOM   35   C CG  . TYR A 1 8   ? 35.571 -20.492 10.828  1.00 19.85 ? 8   TYR A CG  1 
ATOM   36   C CD1 . TYR A 1 8   ? 36.797 -21.136 10.978  1.00 26.43 ? 8   TYR A CD1 1 
ATOM   37   C CD2 . TYR A 1 8   ? 35.056 -20.352 9.554   1.00 17.40 ? 8   TYR A CD2 1 
ATOM   38   C CE1 . TYR A 1 8   ? 37.455 -21.689 9.889   1.00 24.05 ? 8   TYR A CE1 1 
ATOM   39   C CE2 . TYR A 1 8   ? 35.706 -20.887 8.458   1.00 17.00 ? 8   TYR A CE2 1 
ATOM   40   C CZ  . TYR A 1 8   ? 36.907 -21.554 8.624   1.00 25.76 ? 8   TYR A CZ  1 
ATOM   41   O OH  . TYR A 1 8   ? 37.561 -22.084 7.523   1.00 26.91 ? 8   TYR A OH  1 
ATOM   42   N N   . THR A 1 9   ? 36.510 -17.263 10.585  1.00 15.49 ? 9   THR A N   1 
ATOM   43   C CA  . THR A 1 9   ? 36.530 -16.332 9.463   1.00 17.49 ? 9   THR A CA  1 
ATOM   44   C C   . THR A 1 9   ? 37.230 -16.968 8.266   1.00 20.08 ? 9   THR A C   1 
ATOM   45   O O   . THR A 1 9   ? 38.305 -17.560 8.414   1.00 19.12 ? 9   THR A O   1 
ATOM   46   C CB  . THR A 1 9   ? 37.245 -15.030 9.848   1.00 22.18 ? 9   THR A CB  1 
ATOM   47   O OG1 . THR A 1 9   ? 36.535 -14.379 10.911  1.00 23.25 ? 9   THR A OG1 1 
ATOM   48   C CG2 . THR A 1 9   ? 37.310 -14.101 8.657   1.00 23.07 ? 9   THR A CG2 1 
ATOM   49   N N   . GLU A 1 10  ? 36.628 -16.837 7.078   1.00 13.95 ? 10  GLU A N   1 
ATOM   50   C CA  . GLU A 1 10  ? 37.248 -17.309 5.843   1.00 13.40 ? 10  GLU A CA  1 
ATOM   51   C C   . GLU A 1 10  ? 36.982 -16.315 4.717   1.00 15.22 ? 10  GLU A C   1 
ATOM   52   O O   . GLU A 1 10  ? 35.839 -15.894 4.509   1.00 12.19 ? 10  GLU A O   1 
ATOM   53   C CB  . GLU A 1 10  ? 36.738 -18.710 5.461   1.00 14.86 ? 10  GLU A CB  1 
ATOM   54   C CG  . GLU A 1 10  ? 37.523 -19.355 4.299   1.00 18.14 ? 10  GLU A CG  1 
ATOM   55   C CD  . GLU A 1 10  ? 37.136 -20.813 4.028   1.00 20.62 ? 10  GLU A CD  1 
ATOM   56   O OE1 . GLU A 1 10  ? 37.168 -21.633 4.979   1.00 20.19 ? 10  GLU A OE1 1 
ATOM   57   O OE2 . GLU A 1 10  ? 36.810 -21.139 2.856   1.00 20.90 ? 10  GLU A OE2 1 
ATOM   58   N N   . ALA A 1 11  ? 38.036 -15.913 4.010   1.00 13.28 ? 11  ALA A N   1 
ATOM   59   C CA  . ALA A 1 11  ? 37.840 -15.148 2.786   1.00 15.44 ? 11  ALA A CA  1 
ATOM   60   C C   . ALA A 1 11  ? 37.004 -15.976 1.815   1.00 11.48 ? 11  ALA A C   1 
ATOM   61   O O   . ALA A 1 11  ? 37.130 -17.200 1.761   1.00 12.65 ? 11  ALA A O   1 
ATOM   62   C CB  . ALA A 1 11  ? 39.185 -14.778 2.151   1.00 14.68 ? 11  ALA A CB  1 
ATOM   63   N N   . ALA A 1 12  ? 36.127 -15.317 1.064   1.00 12.01 ? 12  ALA A N   1 
ATOM   64   C CA  . ALA A 1 12  ? 35.217 -16.088 0.223   1.00 11.02 ? 12  ALA A CA  1 
ATOM   65   C C   . ALA A 1 12  ? 34.710 -15.237 -0.923  1.00 13.05 ? 12  ALA A C   1 
ATOM   66   O O   . ALA A 1 12  ? 34.675 -14.007 -0.843  1.00 15.44 ? 12  ALA A O   1 
ATOM   67   C CB  . ALA A 1 12  ? 34.021 -16.634 1.019   1.00 13.92 ? 12  ALA A CB  1 
ATOM   68   N N   . SER A 1 13  ? 34.289 -15.923 -1.981  1.00 10.83 ? 13  SER A N   1 
ATOM   69   C CA  . SER A 1 13  ? 33.600 -15.324 -3.110  1.00 14.83 ? 13  SER A CA  1 
ATOM   70   C C   . SER A 1 13  ? 32.354 -16.151 -3.380  1.00 16.53 ? 13  SER A C   1 
ATOM   71   O O   . SER A 1 13  ? 32.378 -17.379 -3.240  1.00 15.19 ? 13  SER A O   1 
ATOM   72   C CB  . SER A 1 13  ? 34.480 -15.306 -4.367  1.00 18.64 ? 13  SER A CB  1 
ATOM   73   O OG  . SER A 1 13  ? 35.510 -14.354 -4.235  1.00 22.07 ? 13  SER A OG  1 
ATOM   74   N N   . LEU A 1 14  ? 31.276 -15.481 -3.770  1.00 12.43 ? 14  LEU A N   1 
ATOM   75   C CA  . LEU A 1 14  ? 30.004 -16.144 -4.003  1.00 13.48 ? 14  LEU A CA  1 
ATOM   76   C C   . LEU A 1 14  ? 29.415 -15.691 -5.329  1.00 15.21 ? 14  LEU A C   1 
ATOM   77   O O   . LEU A 1 14  ? 29.547 -14.530 -5.720  1.00 15.48 ? 14  LEU A O   1 
ATOM   78   C CB  . LEU A 1 14  ? 28.986 -15.843 -2.884  1.00 15.51 ? 14  LEU A CB  1 
ATOM   79   C CG  . LEU A 1 14  ? 29.365 -16.210 -1.448  1.00 12.22 ? 14  LEU A CG  1 
ATOM   80   C CD1 . LEU A 1 14  ? 28.231 -15.807 -0.514  1.00 16.17 ? 14  LEU A CD1 1 
ATOM   81   C CD2 . LEU A 1 14  ? 29.669 -17.690 -1.332  1.00 10.85 ? 14  LEU A CD2 1 
ATOM   82   N N   . SER A 1 15  ? 28.736 -16.612 -6.000  1.00 15.68 ? 15  SER A N   1 
ATOM   83   C CA  . SER A 1 15  ? 27.907 -16.256 -7.143  1.00 19.13 ? 15  SER A CA  1 
ATOM   84   C C   . SER A 1 15  ? 26.816 -17.309 -7.274  1.00 19.60 ? 15  SER A C   1 
ATOM   85   O O   . SER A 1 15  ? 26.755 -18.261 -6.494  1.00 13.84 ? 15  SER A O   1 
ATOM   86   C CB  . SER A 1 15  ? 28.751 -16.140 -8.412  1.00 19.96 ? 15  SER A CB  1 
ATOM   87   O OG  . SER A 1 15  ? 29.371 -17.382 -8.685  1.00 24.70 ? 15  SER A OG  1 
ATOM   88   N N   . THR A 1 16  ? 25.943 -17.139 -8.265  1.00 21.16 ? 16  THR A N   1 
ATOM   89   C CA  . THR A 1 16  ? 24.875 -18.112 -8.460  1.00 18.96 ? 16  THR A CA  1 
ATOM   90   C C   . THR A 1 16  ? 25.454 -19.516 -8.557  1.00 19.12 ? 16  THR A C   1 
ATOM   91   O O   . THR A 1 16  ? 26.386 -19.762 -9.317  1.00 20.91 ? 16  THR A O   1 
ATOM   92   C CB  . THR A 1 16  ? 24.090 -17.775 -9.726  1.00 20.35 ? 16  THR A CB  1 
ATOM   93   O OG1 . THR A 1 16  ? 23.529 -16.467 -9.588  1.00 21.14 ? 16  THR A OG1 1 
ATOM   94   C CG2 . THR A 1 16  ? 22.981 -18.794 -9.932  1.00 22.65 ? 16  THR A CG2 1 
ATOM   95   N N   . GLY A 1 17  ? 24.917 -20.436 -7.763  1.00 16.95 ? 17  GLY A N   1 
ATOM   96   C CA  . GLY A 1 17  ? 25.419 -21.789 -7.716  1.00 19.21 ? 17  GLY A CA  1 
ATOM   97   C C   . GLY A 1 17  ? 26.363 -22.070 -6.557  1.00 19.51 ? 17  GLY A C   1 
ATOM   98   O O   . GLY A 1 17  ? 26.615 -23.240 -6.253  1.00 17.53 ? 17  GLY A O   1 
ATOM   99   N N   . SER A 1 18  ? 26.873 -21.035 -5.892  1.00 13.69 ? 18  SER A N   1 
ATOM   100  C CA  . SER A 1 18  ? 27.735 -21.252 -4.732  1.00 15.58 ? 18  SER A CA  1 
ATOM   101  C C   . SER A 1 18  ? 26.929 -21.820 -3.569  1.00 18.03 ? 18  SER A C   1 
ATOM   102  O O   . SER A 1 18  ? 25.776 -21.431 -3.349  1.00 15.13 ? 18  SER A O   1 
ATOM   103  C CB  . SER A 1 18  ? 28.379 -19.935 -4.305  1.00 12.26 ? 18  SER A CB  1 
ATOM   104  O OG  . SER A 1 18  ? 29.220 -19.437 -5.312  1.00 13.98 ? 18  SER A OG  1 
ATOM   105  N N   . THR A 1 19  ? 27.547 -22.733 -2.815  1.00 14.50 ? 19  THR A N   1 
ATOM   106  C CA  . THR A 1 19  ? 26.976 -23.283 -1.591  1.00 14.24 ? 19  THR A CA  1 
ATOM   107  C C   . THR A 1 19  ? 27.950 -23.107 -0.428  1.00 14.01 ? 19  THR A C   1 
ATOM   108  O O   . THR A 1 19  ? 29.134 -23.431 -0.556  1.00 14.36 ? 19  THR A O   1 
ATOM   109  C CB  . THR A 1 19  ? 26.652 -24.769 -1.761  1.00 18.85 ? 19  THR A CB  1 
ATOM   110  O OG1 . THR A 1 19  ? 25.683 -24.921 -2.806  1.00 19.50 ? 19  THR A OG1 1 
ATOM   111  C CG2 . THR A 1 19  ? 26.091 -25.351 -0.483  1.00 18.55 ? 19  THR A CG2 1 
ATOM   112  N N   . VAL A 1 20  ? 27.445 -22.642 0.711   1.00 11.61 ? 20  VAL A N   1 
ATOM   113  C CA  . VAL A 1 20  ? 28.219 -22.557 1.949   1.00 10.78 ? 20  VAL A CA  1 
ATOM   114  C C   . VAL A 1 20  ? 27.682 -23.611 2.905   1.00 16.36 ? 20  VAL A C   1 
ATOM   115  O O   . VAL A 1 20  ? 26.496 -23.577 3.272   1.00 13.42 ? 20  VAL A O   1 
ATOM   116  C CB  . VAL A 1 20  ? 28.132 -21.162 2.580   1.00 11.59 ? 20  VAL A CB  1 
ATOM   117  C CG1 . VAL A 1 20  ? 29.000 -21.098 3.870   1.00 11.29 ? 20  VAL A CG1 1 
ATOM   118  C CG2 . VAL A 1 20  ? 28.537 -20.096 1.583   1.00 12.62 ? 20  VAL A CG2 1 
ATOM   119  N N   . THR A 1 21  ? 28.553 -24.538 3.317   1.00 10.47 ? 21  THR A N   1 
ATOM   120  C CA  . THR A 1 21  ? 28.159 -25.678 4.135   1.00 13.74 ? 21  THR A CA  1 
ATOM   121  C C   . THR A 1 21  ? 28.845 -25.560 5.481   1.00 18.12 ? 21  THR A C   1 
ATOM   122  O O   . THR A 1 21  ? 30.075 -25.446 5.551   1.00 17.15 ? 21  THR A O   1 
ATOM   123  C CB  . THR A 1 21  ? 28.538 -27.011 3.496   1.00 16.73 ? 21  THR A CB  1 
ATOM   124  O OG1 . THR A 1 21  ? 27.959 -27.090 2.193   1.00 19.17 ? 21  THR A OG1 1 
ATOM   125  C CG2 . THR A 1 21  ? 28.020 -28.167 4.348   1.00 18.12 ? 21  THR A CG2 1 
ATOM   126  N N   . ILE A 1 22  ? 28.048 -25.580 6.537   1.00 14.20 ? 22  ILE A N   1 
ATOM   127  C CA  . ILE A 1 22  ? 28.533 -25.366 7.893   1.00 13.50 ? 22  ILE A CA  1 
ATOM   128  C C   . ILE A 1 22  ? 28.011 -26.522 8.722   1.00 18.58 ? 22  ILE A C   1 
ATOM   129  O O   . ILE A 1 22  ? 26.812 -26.780 8.714   1.00 21.67 ? 22  ILE A O   1 
ATOM   130  C CB  . ILE A 1 22  ? 28.028 -24.029 8.470   1.00 15.49 ? 22  ILE A CB  1 
ATOM   131  C CG1 . ILE A 1 22  ? 28.458 -22.865 7.567   1.00 15.70 ? 22  ILE A CG1 1 
ATOM   132  C CG2 . ILE A 1 22  ? 28.529 -23.827 9.924   1.00 20.23 ? 22  ILE A CG2 1 
ATOM   133  C CD1 . ILE A 1 22  ? 27.659 -21.588 7.871   1.00 18.43 ? 22  ILE A CD1 1 
ATOM   134  N N   . LYS A 1 23  ? 28.906 -27.192 9.451   1.00 14.55 ? 23  LYS A N   1 
ATOM   135  C CA  . LYS A 1 23  ? 28.508 -28.276 10.337  1.00 18.49 ? 23  LYS A CA  1 
ATOM   136  C C   . LYS A 1 23  ? 29.004 -27.972 11.751  1.00 19.45 ? 23  LYS A C   1 
ATOM   137  O O   . LYS A 1 23  ? 30.201 -27.719 11.989  1.00 14.81 ? 23  LYS A O   1 
ATOM   138  C CB  . LYS A 1 23  ? 29.064 -29.554 9.810   1.00 22.80 ? 23  LYS A CB  1 
ATOM   139  C CG  . LYS A 1 23  ? 28.697 -30.814 10.409  1.00 29.12 ? 23  LYS A CG  1 
ATOM   140  C CD  . LYS A 1 23  ? 29.519 -31.740 9.539   1.00 38.89 ? 23  LYS A CD  1 
ATOM   141  C CE  . LYS A 1 23  ? 28.821 -31.752 8.095   1.00 43.88 ? 23  LYS A CE  1 
ATOM   142  N NZ  . LYS A 1 23  ? 29.506 -32.718 7.221   1.00 44.83 ? 23  LYS A NZ  1 
ATOM   143  N N   . GLY A 1 24  ? 28.095 -28.083 12.710  1.00 20.37 ? 24  GLY A N   1 
ATOM   144  C CA  . GLY A 1 24  ? 28.411 -27.586 14.019  1.00 18.61 ? 24  GLY A CA  1 
ATOM   145  C C   . GLY A 1 24  ? 27.387 -27.975 15.045  1.00 19.27 ? 24  GLY A C   1 
ATOM   146  O O   . GLY A 1 24  ? 26.617 -28.916 14.854  1.00 17.45 ? 24  GLY A O   1 
ATOM   147  N N   . ARG A 1 25  ? 27.312 -27.188 16.098  1.00 19.38 ? 25  ARG A N   1 
ATOM   148  C CA  . ARG A 1 25  ? 26.873 -27.795 17.335  1.00 19.19 ? 25  ARG A CA  1 
ATOM   149  C C   . ARG A 1 25  ? 26.651 -26.728 18.400  1.00 15.99 ? 25  ARG A C   1 
ATOM   150  O O   . ARG A 1 25  ? 27.635 -26.067 18.753  1.00 16.33 ? 25  ARG A O   1 
ATOM   151  C CB  . ARG A 1 25  ? 28.007 -28.665 17.809  1.00 29.39 ? 25  ARG A CB  1 
ATOM   152  C CG  . ARG A 1 25  ? 27.745 -29.365 19.013  1.00 31.07 ? 25  ARG A CG  1 
ATOM   153  C CD  . ARG A 1 25  ? 26.678 -30.349 18.537  1.00 35.59 ? 25  ARG A CD  1 
ATOM   154  N NE  . ARG A 1 25  ? 26.260 -31.222 19.605  1.00 40.50 ? 25  ARG A NE  1 
ATOM   155  C CZ  . ARG A 1 25  ? 26.905 -32.369 19.814  1.00 45.06 ? 25  ARG A CZ  1 
ATOM   156  N NH1 . ARG A 1 25  ? 26.569 -33.173 20.795  1.00 53.71 ? 25  ARG A NH1 1 
ATOM   157  N NH2 . ARG A 1 25  ? 27.918 -32.701 19.024  1.00 52.51 ? 25  ARG A NH2 1 
ATOM   158  N N   . PRO A 1 26  ? 25.450 -26.527 18.968  1.00 15.07 ? 26  PRO A N   1 
ATOM   159  C CA  . PRO A 1 26  ? 25.319 -25.465 19.976  1.00 14.40 ? 26  PRO A CA  1 
ATOM   160  C C   . PRO A 1 26  ? 26.140 -25.799 21.216  1.00 17.11 ? 26  PRO A C   1 
ATOM   161  O O   . PRO A 1 26  ? 26.329 -26.965 21.554  1.00 18.19 ? 26  PRO A O   1 
ATOM   162  C CB  . PRO A 1 26  ? 23.819 -25.434 20.293  1.00 15.54 ? 26  PRO A CB  1 
ATOM   163  C CG  . PRO A 1 26  ? 23.154 -26.137 19.122  1.00 16.71 ? 26  PRO A CG  1 
ATOM   164  C CD  . PRO A 1 26  ? 24.153 -27.172 18.681  1.00 16.74 ? 26  PRO A CD  1 
ATOM   165  N N   . LEU A 1 27  ? 26.610 -24.760 21.909  1.00 15.86 ? 27  LEU A N   1 
ATOM   166  C CA  . LEU A 1 27  ? 27.433 -24.951 23.103  1.00 18.67 ? 27  LEU A CA  1 
ATOM   167  C C   . LEU A 1 27  ? 26.603 -25.105 24.372  1.00 18.96 ? 27  LEU A C   1 
ATOM   168  O O   . LEU A 1 27  ? 27.172 -25.307 25.454  1.00 20.40 ? 27  LEU A O   1 
ATOM   169  C CB  . LEU A 1 27  ? 28.402 -23.780 23.270  1.00 16.83 ? 27  LEU A CB  1 
ATOM   170  C CG  . LEU A 1 27  ? 29.468 -23.639 22.179  1.00 15.15 ? 27  LEU A CG  1 
ATOM   171  C CD1 . LEU A 1 27  ? 30.255 -22.349 22.389  1.00 20.03 ? 27  LEU A CD1 1 
ATOM   172  C CD2 . LEU A 1 27  ? 30.389 -24.857 22.141  1.00 20.24 ? 27  LEU A CD2 1 
ATOM   173  N N   . ALA A 1 28  ? 25.282 -25.007 24.264  1.00 17.23 ? 28  ALA A N   1 
ATOM   174  C CA  . ALA A 1 28  ? 24.398 -25.152 25.412  1.00 19.13 ? 28  ALA A CA  1 
ATOM   175  C C   . ALA A 1 28  ? 23.069 -25.728 24.936  1.00 20.99 ? 28  ALA A C   1 
ATOM   176  O O   . ALA A 1 28  ? 22.756 -25.703 23.743  1.00 15.70 ? 28  ALA A O   1 
ATOM   177  C CB  . ALA A 1 28  ? 24.209 -23.805 26.123  1.00 19.18 ? 28  ALA A CB  1 
ATOM   178  N N   . CYS A 1 29  ? 22.296 -26.280 25.872  1.00 18.81 ? 29  CYS A N   1 
ATOM   179  C CA  . CYS A 1 29  ? 20.954 -26.738 25.526  1.00 19.23 ? 29  CYS A CA  1 
ATOM   180  C C   . CYS A 1 29  ? 20.040 -25.552 25.215  1.00 21.17 ? 29  CYS A C   1 
ATOM   181  O O   . CYS A 1 29  ? 20.310 -24.406 25.594  1.00 17.54 ? 29  CYS A O   1 
ATOM   182  C CB  . CYS A 1 29  ? 20.358 -27.594 26.648  1.00 27.88 ? 29  CYS A CB  1 
ATOM   183  S SG  . CYS A 1 29  ? 21.418 -28.991 27.152  1.00 34.24 ? 29  CYS A SG  1 
ATOM   184  N N   . PHE A 1 30  ? 18.930 -25.845 24.520  1.00 19.28 ? 30  PHE A N   1 
ATOM   185  C CA  . PHE A 1 30  ? 18.081 -24.767 24.016  1.00 16.58 ? 30  PHE A CA  1 
ATOM   186  C C   . PHE A 1 30  ? 17.512 -23.924 25.146  1.00 20.12 ? 30  PHE A C   1 
ATOM   187  O O   . PHE A 1 30  ? 17.231 -22.740 24.950  1.00 16.63 ? 30  PHE A O   1 
ATOM   188  C CB  . PHE A 1 30  ? 16.930 -25.320 23.165  1.00 18.75 ? 30  PHE A CB  1 
ATOM   189  C CG  . PHE A 1 30  ? 17.332 -25.747 21.783  1.00 21.86 ? 30  PHE A CG  1 
ATOM   190  C CD1 . PHE A 1 30  ? 18.665 -25.784 21.405  1.00 18.67 ? 30  PHE A CD1 1 
ATOM   191  C CD2 . PHE A 1 30  ? 16.361 -26.067 20.836  1.00 22.63 ? 30  PHE A CD2 1 
ATOM   192  C CE1 . PHE A 1 30  ? 19.024 -26.170 20.131  1.00 22.00 ? 30  PHE A CE1 1 
ATOM   193  C CE2 . PHE A 1 30  ? 16.716 -26.449 19.566  1.00 21.91 ? 30  PHE A CE2 1 
ATOM   194  C CZ  . PHE A 1 30  ? 18.053 -26.501 19.210  1.00 19.44 ? 30  PHE A CZ  1 
ATOM   195  N N   . LEU A 1 31  ? 17.337 -24.514 26.334  1.00 18.49 ? 31  LEU A N   1 
ATOM   196  C CA  . LEU A 1 31  ? 16.825 -23.765 27.475  1.00 20.41 ? 31  LEU A CA  1 
ATOM   197  C C   . LEU A 1 31  ? 17.695 -22.552 27.799  1.00 19.60 ? 31  LEU A C   1 
ATOM   198  O O   . LEU A 1 31  ? 17.183 -21.529 28.260  1.00 17.66 ? 31  LEU A O   1 
ATOM   199  C CB  . LEU A 1 31  ? 16.722 -24.702 28.680  1.00 24.83 ? 31  LEU A CB  1 
ATOM   200  C CG  . LEU A 1 31  ? 16.240 -24.136 30.009  1.00 28.04 ? 31  LEU A CG  1 
ATOM   201  C CD1 . LEU A 1 31  ? 14.715 -24.047 30.016  1.00 29.89 ? 31  LEU A CD1 1 
ATOM   202  C CD2 . LEU A 1 31  ? 16.738 -25.036 31.137  1.00 28.95 ? 31  LEU A CD2 1 
ATOM   203  N N   . ALA A 1 32  ? 19.001 -22.634 27.534  1.00 20.51 ? 32  ALA A N   1 
ATOM   204  C CA  . ALA A 1 32  ? 19.916 -21.517 27.755  1.00 17.01 ? 32  ALA A CA  1 
ATOM   205  C C   . ALA A 1 32  ? 19.898 -20.486 26.625  1.00 17.75 ? 32  ALA A C   1 
ATOM   206  O O   . ALA A 1 32  ? 20.584 -19.459 26.743  1.00 15.99 ? 32  ALA A O   1 
ATOM   207  C CB  . ALA A 1 32  ? 21.346 -22.056 27.943  1.00 15.66 ? 32  ALA A CB  1 
ATOM   208  N N   . GLU A 1 33  ? 19.129 -20.728 25.555  1.00 14.37 ? 33  GLU A N   1 
ATOM   209  C CA  . GLU A 1 33  ? 19.098 -19.891 24.370  1.00 16.99 ? 33  GLU A CA  1 
ATOM   210  C C   . GLU A 1 33  ? 20.469 -19.514 23.826  1.00 11.99 ? 33  GLU A C   1 
ATOM   211  O O   . GLU A 1 33  ? 20.832 -18.340 23.758  1.00 12.95 ? 33  GLU A O   1 
ATOM   212  C CB  . GLU A 1 33  ? 18.269 -18.614 24.628  1.00 19.01 ? 33  GLU A CB  1 
ATOM   213  C CG  . GLU A 1 33  ? 16.944 -18.856 25.364  1.00 25.37 ? 33  GLU A CG  1 
ATOM   214  C CD  . GLU A 1 33  ? 15.874 -17.811 25.030  1.00 35.48 ? 33  GLU A CD  1 
ATOM   215  O OE1 . GLU A 1 33  ? 16.169 -16.841 24.295  1.00 34.13 ? 33  GLU A OE1 1 
ATOM   216  O OE2 . GLU A 1 33  ? 14.722 -17.981 25.477  1.00 44.68 ? 33  GLU A OE2 1 
ATOM   217  N N   . PRO A 1 34  ? 21.267 -20.505 23.406  1.00 13.13 ? 34  PRO A N   1 
ATOM   218  C CA  . PRO A 1 34  ? 22.503 -20.184 22.691  1.00 13.78 ? 34  PRO A CA  1 
ATOM   219  C C   . PRO A 1 34  ? 22.157 -19.566 21.348  1.00 12.00 ? 34  PRO A C   1 
ATOM   220  O O   . PRO A 1 34  ? 21.054 -19.742 20.824  1.00 12.63 ? 34  PRO A O   1 
ATOM   221  C CB  . PRO A 1 34  ? 23.184 -21.545 22.518  1.00 11.31 ? 34  PRO A CB  1 
ATOM   222  C CG  . PRO A 1 34  ? 22.043 -22.506 22.455  1.00 14.55 ? 34  PRO A CG  1 
ATOM   223  C CD  . PRO A 1 34  ? 21.000 -21.958 23.410  1.00 12.24 ? 34  PRO A CD  1 
ATOM   224  N N   . TYR A 1 35  ? 23.108 -18.819 20.795  1.00 14.10 ? 35  TYR A N   1 
ATOM   225  C CA  . TYR A 1 35  ? 22.941 -18.225 19.476  1.00 13.71 ? 35  TYR A CA  1 
ATOM   226  C C   . TYR A 1 35  ? 23.907 -18.836 18.467  1.00 14.49 ? 35  TYR A C   1 
ATOM   227  O O   . TYR A 1 35  ? 24.940 -19.419 18.822  1.00 11.93 ? 35  TYR A O   1 
ATOM   228  C CB  . TYR A 1 35  ? 23.173 -16.703 19.488  1.00 14.68 ? 35  TYR A CB  1 
ATOM   229  C CG  . TYR A 1 35  ? 22.037 -15.876 20.035  1.00 22.35 ? 35  TYR A CG  1 
ATOM   230  C CD1 . TYR A 1 35  ? 21.559 -16.078 21.323  1.00 21.77 ? 35  TYR A CD1 1 
ATOM   231  C CD2 . TYR A 1 35  ? 21.400 -14.912 19.236  1.00 30.79 ? 35  TYR A CD2 1 
ATOM   232  C CE1 . TYR A 1 35  ? 20.500 -15.316 21.831  1.00 29.91 ? 35  TYR A CE1 1 
ATOM   233  C CE2 . TYR A 1 35  ? 20.339 -14.143 19.740  1.00 28.84 ? 35  TYR A CE2 1 
ATOM   234  C CZ  . TYR A 1 35  ? 19.898 -14.357 21.034  1.00 30.95 ? 35  TYR A CZ  1 
ATOM   235  O OH  . TYR A 1 35  ? 18.852 -13.616 21.540  1.00 41.97 ? 35  TYR A OH  1 
ATOM   236  N N   . LEU A 1 36  ? 23.563 -18.652 17.188  1.00 13.46 ? 36  LEU A N   1 
ATOM   237  C CA  . LEU A 1 36  ? 24.455 -18.903 16.059  1.00 12.61 ? 36  LEU A CA  1 
ATOM   238  C C   . LEU A 1 36  ? 24.314 -17.724 15.109  1.00 12.60 ? 36  LEU A C   1 
ATOM   239  O O   . LEU A 1 36  ? 23.185 -17.312 14.814  1.00 13.72 ? 36  LEU A O   1 
ATOM   240  C CB  . LEU A 1 36  ? 24.103 -20.207 15.330  1.00 12.65 ? 36  LEU A CB  1 
ATOM   241  C CG  . LEU A 1 36  ? 24.592 -20.338 13.871  1.00 14.98 ? 36  LEU A CG  1 
ATOM   242  C CD1 . LEU A 1 36  ? 26.112 -20.435 13.815  1.00 13.52 ? 36  LEU A CD1 1 
ATOM   243  C CD2 . LEU A 1 36  ? 23.951 -21.520 13.161  1.00 14.93 ? 36  LEU A CD2 1 
ATOM   244  N N   . GLN A 1 37  ? 25.437 -17.179 14.631  1.00 10.81 ? 37  GLN A N   1 
ATOM   245  C CA  . GLN A 1 37  ? 25.389 -16.087 13.666  1.00 9.99  ? 37  GLN A CA  1 
ATOM   246  C C   . GLN A 1 37  ? 26.310 -16.388 12.491  1.00 13.54 ? 37  GLN A C   1 
ATOM   247  O O   . GLN A 1 37  ? 27.471 -16.771 12.684  1.00 9.84  ? 37  GLN A O   1 
ATOM   248  C CB  . GLN A 1 37  ? 25.763 -14.742 14.301  1.00 8.80  ? 37  GLN A CB  1 
ATOM   249  C CG  . GLN A 1 37  ? 25.540 -13.517 13.386  1.00 10.64 ? 37  GLN A CG  1 
ATOM   250  C CD  . GLN A 1 37  ? 25.376 -12.221 14.185  1.00 13.41 ? 37  GLN A CD  1 
ATOM   251  O OE1 . GLN A 1 37  ? 24.783 -12.218 15.274  1.00 13.52 ? 37  GLN A OE1 1 
ATOM   252  N NE2 . GLN A 1 37  ? 25.892 -11.118 13.649  1.00 10.59 ? 37  GLN A NE2 1 
ATOM   253  N N   . VAL A 1 38  ? 25.786 -16.212 11.278  1.00 10.98 ? 38  VAL A N   1 
ATOM   254  C CA  . VAL A 1 38  ? 26.546 -16.348 10.034  1.00 9.78  ? 38  VAL A CA  1 
ATOM   255  C C   . VAL A 1 38  ? 26.385 -15.027 9.288   1.00 11.29 ? 38  VAL A C   1 
ATOM   256  O O   . VAL A 1 38  ? 25.253 -14.597 9.030   1.00 13.15 ? 38  VAL A O   1 
ATOM   257  C CB  . VAL A 1 38  ? 26.042 -17.523 9.177   1.00 8.49  ? 38  VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 38  ? 26.811 -17.604 7.843   1.00 7.67  ? 38  VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 38  ? 26.121 -18.834 9.955   1.00 12.31 ? 38  VAL A CG2 1 
ATOM   260  N N   . ASP A 1 39  ? 27.502 -14.374 8.962   1.00 9.20  ? 39  ASP A N   1 
ATOM   261  C CA  . ASP A 1 39  ? 27.479 -13.078 8.295   1.00 8.13  ? 39  ASP A CA  1 
ATOM   262  C C   . ASP A 1 39  ? 28.316 -13.159 7.027   1.00 10.19 ? 39  ASP A C   1 
ATOM   263  O O   . ASP A 1 39  ? 29.476 -13.568 7.084   1.00 10.69 ? 39  ASP A O   1 
ATOM   264  C CB  . ASP A 1 39  ? 28.035 -11.975 9.196   1.00 10.94 ? 39  ASP A CB  1 
ATOM   265  C CG  . ASP A 1 39  ? 27.189 -11.750 10.446  1.00 13.01 ? 39  ASP A CG  1 
ATOM   266  O OD1 . ASP A 1 39  ? 25.958 -11.666 10.336  1.00 12.91 ? 39  ASP A OD1 1 
ATOM   267  O OD2 . ASP A 1 39  ? 27.763 -11.660 11.551  1.00 13.52 ? 39  ASP A OD2 1 
ATOM   268  N N   . PHE A 1 40  ? 27.736 -12.776 5.890   1.00 10.74 ? 40  PHE A N   1 
ATOM   269  C CA  . PHE A 1 40  ? 28.473 -12.629 4.629   1.00 12.16 ? 40  PHE A CA  1 
ATOM   270  C C   . PHE A 1 40  ? 28.862 -11.162 4.470   1.00 11.83 ? 40  PHE A C   1 
ATOM   271  O O   . PHE A 1 40  ? 27.994 -10.319 4.228   1.00 13.41 ? 40  PHE A O   1 
ATOM   272  C CB  . PHE A 1 40  ? 27.649 -13.077 3.418   1.00 11.02 ? 40  PHE A CB  1 
ATOM   273  C CG  . PHE A 1 40  ? 27.238 -14.538 3.422   1.00 10.63 ? 40  PHE A CG  1 
ATOM   274  C CD1 . PHE A 1 40  ? 27.751 -15.438 4.334   1.00 11.79 ? 40  PHE A CD1 1 
ATOM   275  C CD2 . PHE A 1 40  ? 26.390 -15.015 2.429   1.00 12.97 ? 40  PHE A CD2 1 
ATOM   276  C CE1 . PHE A 1 40  ? 27.372 -16.784 4.303   1.00 11.83 ? 40  PHE A CE1 1 
ATOM   277  C CE2 . PHE A 1 40  ? 26.015 -16.347 2.381   1.00 13.27 ? 40  PHE A CE2 1 
ATOM   278  C CZ  . PHE A 1 40  ? 26.510 -17.236 3.313   1.00 13.73 ? 40  PHE A CZ  1 
ATOM   279  N N   . HIS A 1 41  ? 30.168 -10.862 4.579   1.00 10.58 ? 41  HIS A N   1 
ATOM   280  C CA  . HIS A 1 41  ? 30.703 -9.503  4.617   1.00 10.41 ? 41  HIS A CA  1 
ATOM   281  C C   . HIS A 1 41  ? 31.245 -9.063  3.264   1.00 11.85 ? 41  HIS A C   1 
ATOM   282  O O   . HIS A 1 41  ? 31.707 -9.884  2.477   1.00 11.70 ? 41  HIS A O   1 
ATOM   283  C CB  . HIS A 1 41  ? 31.851 -9.410  5.623   1.00 10.00 ? 41  HIS A CB  1 
ATOM   284  C CG  . HIS A 1 41  ? 31.409 -9.272  7.041   1.00 12.42 ? 41  HIS A CG  1 
ATOM   285  N ND1 . HIS A 1 41  ? 31.234 -8.046  7.650   1.00 15.18 ? 41  HIS A ND1 1 
ATOM   286  C CD2 . HIS A 1 41  ? 31.124 -10.206 7.977   1.00 10.51 ? 41  HIS A CD2 1 
ATOM   287  C CE1 . HIS A 1 41  ? 30.863 -8.235  8.905   1.00 15.68 ? 41  HIS A CE1 1 
ATOM   288  N NE2 . HIS A 1 41  ? 30.790 -9.536  9.128   1.00 13.06 ? 41  HIS A NE2 1 
ATOM   289  N N   . THR A 1 42  ? 31.250 -7.749  3.030   1.00 13.03 ? 42  THR A N   1 
ATOM   290  C CA  . THR A 1 42  ? 31.795 -7.197  1.792   1.00 12.70 ? 42  THR A CA  1 
ATOM   291  C C   . THR A 1 42  ? 33.299 -6.970  1.843   1.00 15.79 ? 42  THR A C   1 
ATOM   292  O O   . THR A 1 42  ? 33.902 -6.723  0.796   1.00 15.42 ? 42  THR A O   1 
ATOM   293  C CB  . THR A 1 42  ? 31.132 -5.864  1.442   1.00 14.81 ? 42  THR A CB  1 
ATOM   294  O OG1 . THR A 1 42  ? 31.293 -4.952  2.534   1.00 16.32 ? 42  THR A OG1 1 
ATOM   295  C CG2 . THR A 1 42  ? 29.663 -6.049  1.142   1.00 14.89 ? 42  THR A CG2 1 
ATOM   296  N N   . GLU A 1 43  ? 33.916 -7.008  3.022   1.00 11.69 ? 43  GLU A N   1 
ATOM   297  C CA  . GLU A 1 43  ? 35.360 -6.857  3.151   1.00 15.72 ? 43  GLU A CA  1 
ATOM   298  C C   . GLU A 1 43  ? 35.828 -7.807  4.239   1.00 16.47 ? 43  GLU A C   1 
ATOM   299  O O   . GLU A 1 43  ? 35.023 -8.362  4.989   1.00 16.26 ? 43  GLU A O   1 
ATOM   300  C CB  . GLU A 1 43  ? 35.762 -5.405  3.479   1.00 17.34 ? 43  GLU A CB  1 
ATOM   301  C CG  . GLU A 1 43  ? 35.289 -4.364  2.473   1.00 21.87 ? 43  GLU A CG  1 
ATOM   302  C CD  . GLU A 1 43  ? 36.037 -4.440  1.139   1.00 25.98 ? 43  GLU A CD  1 
ATOM   303  O OE1 . GLU A 1 43  ? 37.062 -5.159  1.050   1.00 23.88 ? 43  GLU A OE1 1 
ATOM   304  O OE2 . GLU A 1 43  ? 35.555 -3.836  0.157   1.00 25.55 ? 43  GLU A OE2 1 
ATOM   305  N N   . MET A 1 44  ? 37.147 -8.007  4.321   1.00 15.78 ? 44  MET A N   1 
ATOM   306  C CA  . MET A 1 44  ? 37.681 -8.829  5.402   1.00 20.56 ? 44  MET A CA  1 
ATOM   307  C C   . MET A 1 44  ? 37.518 -8.184  6.775   1.00 21.82 ? 44  MET A C   1 
ATOM   308  O O   . MET A 1 44  ? 37.527 -8.900  7.777   1.00 26.91 ? 44  MET A O   1 
ATOM   309  C CB  . MET A 1 44  ? 39.152 -9.162  5.148   1.00 20.63 ? 44  MET A CB  1 
ATOM   310  C CG  . MET A 1 44  ? 39.376 -9.981  3.901   1.00 19.57 ? 44  MET A CG  1 
ATOM   311  S SD  . MET A 1 44  ? 38.705 -11.642 4.148   1.00 24.20 ? 44  MET A SD  1 
ATOM   312  C CE  . MET A 1 44  ? 39.521 -12.203 5.655   1.00 23.42 ? 44  MET A CE  1 
ATOM   313  N N   . LYS A 1 45  ? 37.337 -6.872  6.851   1.00 20.25 ? 45  LYS A N   1 
ATOM   314  C CA  . LYS A 1 45  ? 37.178 -6.213  8.143   1.00 24.36 ? 45  LYS A CA  1 
ATOM   315  C C   . LYS A 1 45  ? 35.789 -6.482  8.721   1.00 22.35 ? 45  LYS A C   1 
ATOM   316  O O   . LYS A 1 45  ? 34.791 -6.493  7.993   1.00 20.77 ? 45  LYS A O   1 
ATOM   317  C CB  . LYS A 1 45  ? 37.415 -4.708  7.998   1.00 26.05 ? 45  LYS A CB  1 
ATOM   318  N N   . GLU A 1 46  ? 35.720 -6.694  10.045  1.00 22.96 ? 46  GLU A N   1 
ATOM   319  C CA  . GLU A 1 46  ? 34.441 -7.043  10.660  1.00 23.48 ? 46  GLU A CA  1 
ATOM   320  C C   . GLU A 1 46  ? 33.461 -5.874  10.677  1.00 21.43 ? 46  GLU A C   1 
ATOM   321  O O   . GLU A 1 46  ? 32.251 -6.104  10.758  1.00 17.90 ? 46  GLU A O   1 
ATOM   322  C CB  . GLU A 1 46  ? 34.646 -7.608  12.083  1.00 30.39 ? 46  GLU A CB  1 
ATOM   323  C CG  . GLU A 1 46  ? 35.361 -6.701  13.093  1.00 35.00 ? 46  GLU A CG  1 
ATOM   324  C CD  . GLU A 1 46  ? 35.148 -7.113  14.578  1.00 41.24 ? 46  GLU A CD  1 
ATOM   325  O OE1 . GLU A 1 46  ? 36.158 -7.487  15.219  1.00 39.47 ? 46  GLU A OE1 1 
ATOM   326  O OE2 . GLU A 1 46  ? 34.009 -7.054  15.111  1.00 27.69 ? 46  GLU A OE2 1 
ATOM   327  N N   . GLU A 1 47  ? 33.925 -4.632  10.562  1.00 18.75 ? 47  GLU A N   1 
ATOM   328  C CA  . GLU A 1 47  ? 32.950 -3.547  10.494  1.00 21.40 ? 47  GLU A CA  1 
ATOM   329  C C   . GLU A 1 47  ? 32.390 -3.340  9.090   1.00 21.72 ? 47  GLU A C   1 
ATOM   330  O O   . GLU A 1 47  ? 31.525 -2.473  8.905   1.00 20.07 ? 47  GLU A O   1 
ATOM   331  C CB  . GLU A 1 47  ? 33.556 -2.235  10.997  1.00 27.29 ? 47  GLU A CB  1 
ATOM   332  C CG  . GLU A 1 47  ? 34.489 -1.538  10.033  1.00 23.92 ? 47  GLU A CG  1 
ATOM   333  C CD  . GLU A 1 47  ? 35.914 -2.047  10.115  1.00 37.24 ? 47  GLU A CD  1 
ATOM   334  O OE1 . GLU A 1 47  ? 36.208 -2.906  10.986  1.00 38.00 ? 47  GLU A OE1 1 
ATOM   335  O OE2 . GLU A 1 47  ? 36.747 -1.539  9.330   1.00 45.95 ? 47  GLU A OE2 1 
ATOM   336  N N   . SER A 1 48  ? 32.842 -4.106  8.100   1.00 14.49 ? 48  SER A N   1 
ATOM   337  C CA  . SER A 1 48  ? 32.320 -3.936  6.750   1.00 15.04 ? 48  SER A CA  1 
ATOM   338  C C   . SER A 1 48  ? 30.841 -4.328  6.683   1.00 16.29 ? 48  SER A C   1 
ATOM   339  O O   . SER A 1 48  ? 30.297 -4.990  7.575   1.00 15.19 ? 48  SER A O   1 
ATOM   340  C CB  . SER A 1 48  ? 33.120 -4.769  5.749   1.00 14.88 ? 48  SER A CB  1 
ATOM   341  O OG  . SER A 1 48  ? 32.941 -6.156  5.979   1.00 13.46 ? 48  SER A OG  1 
ATOM   342  N N   . ASP A 1 49  ? 30.196 -3.911  5.594   1.00 13.99 ? 49  ASP A N   1 
ATOM   343  C CA  . ASP A 1 49  ? 28.785 -4.194  5.356   1.00 14.73 ? 49  ASP A CA  1 
ATOM   344  C C   . ASP A 1 49  ? 28.524 -5.696  5.295   1.00 14.94 ? 49  ASP A C   1 
ATOM   345  O O   . ASP A 1 49  ? 29.412 -6.504  5.022   1.00 12.13 ? 49  ASP A O   1 
ATOM   346  C CB  . ASP A 1 49  ? 28.329 -3.556  4.045   1.00 15.13 ? 49  ASP A CB  1 
ATOM   347  C CG  . ASP A 1 49  ? 28.077 -2.066  4.180   1.00 19.55 ? 49  ASP A CG  1 
ATOM   348  O OD1 . ASP A 1 49  ? 28.157 -1.558  5.312   1.00 19.51 ? 49  ASP A OD1 1 
ATOM   349  O OD2 . ASP A 1 49  ? 27.777 -1.410  3.161   1.00 20.72 ? 49  ASP A OD2 1 
ATOM   350  N N   . ILE A 1 50  ? 27.271 -6.062  5.532   1.00 12.58 ? 50  ILE A N   1 
ATOM   351  C CA  . ILE A 1 50  ? 26.857 -7.453  5.598   1.00 13.20 ? 50  ILE A CA  1 
ATOM   352  C C   . ILE A 1 50  ? 25.741 -7.644  4.595   1.00 12.11 ? 50  ILE A C   1 
ATOM   353  O O   . ILE A 1 50  ? 24.645 -7.084  4.746   1.00 12.23 ? 50  ILE A O   1 
ATOM   354  C CB  . ILE A 1 50  ? 26.417 -7.870  7.006   1.00 12.90 ? 50  ILE A CB  1 
ATOM   355  C CG1 . ILE A 1 50  ? 27.597 -7.742  7.984   1.00 12.13 ? 50  ILE A CG1 1 
ATOM   356  C CG2 . ILE A 1 50  ? 25.891 -9.308  6.979   1.00 12.95 ? 50  ILE A CG2 1 
ATOM   357  C CD1 . ILE A 1 50  ? 27.235 -8.062  9.463   1.00 12.02 ? 50  ILE A CD1 1 
ATOM   358  N N   . VAL A 1 51  ? 26.034 -8.441  3.572   1.00 9.96  ? 51  VAL A N   1 
ATOM   359  C CA  . VAL A 1 51  ? 25.101 -8.721  2.492   1.00 12.12 ? 51  VAL A CA  1 
ATOM   360  C C   . VAL A 1 51  ? 23.988 -9.648  2.963   1.00 11.90 ? 51  VAL A C   1 
ATOM   361  O O   . VAL A 1 51  ? 22.834 -9.537  2.526   1.00 12.59 ? 51  VAL A O   1 
ATOM   362  C CB  . VAL A 1 51  ? 25.902 -9.324  1.325   1.00 15.61 ? 51  VAL A CB  1 
ATOM   363  C CG1 . VAL A 1 51  ? 25.016 -9.952  0.339   1.00 17.59 ? 51  VAL A CG1 1 
ATOM   364  C CG2 . VAL A 1 51  ? 26.746 -8.231  0.668   1.00 15.55 ? 51  VAL A CG2 1 
ATOM   365  N N   . PHE A 1 52  ? 24.319 -10.572 3.862   1.00 12.03 ? 52  PHE A N   1 
ATOM   366  C CA  . PHE A 1 52  ? 23.383 -11.558 4.395   1.00 11.45 ? 52  PHE A CA  1 
ATOM   367  C C   . PHE A 1 52  ? 23.791 -11.838 5.830   1.00 12.82 ? 52  PHE A C   1 
ATOM   368  O O   . PHE A 1 52  ? 24.909 -12.299 6.067   1.00 11.91 ? 52  PHE A O   1 
ATOM   369  C CB  . PHE A 1 52  ? 23.400 -12.854 3.567   1.00 10.26 ? 52  PHE A CB  1 
ATOM   370  C CG  . PHE A 1 52  ? 22.441 -13.911 4.062   1.00 13.79 ? 52  PHE A CG  1 
ATOM   371  C CD1 . PHE A 1 52  ? 21.137 -13.591 4.402   1.00 15.97 ? 52  PHE A CD1 1 
ATOM   372  C CD2 . PHE A 1 52  ? 22.858 -15.220 4.221   1.00 12.68 ? 52  PHE A CD2 1 
ATOM   373  C CE1 . PHE A 1 52  ? 20.261 -14.578 4.865   1.00 14.97 ? 52  PHE A CE1 1 
ATOM   374  C CE2 . PHE A 1 52  ? 21.986 -16.201 4.666   1.00 16.60 ? 52  PHE A CE2 1 
ATOM   375  C CZ  . PHE A 1 52  ? 20.695 -15.882 4.991   1.00 15.00 ? 52  PHE A CZ  1 
ATOM   376  N N   . HIS A 1 53  ? 22.905 -11.525 6.774   1.00 10.78 ? 53  HIS A N   1 
ATOM   377  C CA  . HIS A 1 53  ? 23.084 -11.791 8.197   1.00 10.06 ? 53  HIS A CA  1 
ATOM   378  C C   . HIS A 1 53  ? 22.047 -12.836 8.593   1.00 13.07 ? 53  HIS A C   1 
ATOM   379  O O   . HIS A 1 53  ? 20.864 -12.678 8.271   1.00 14.00 ? 53  HIS A O   1 
ATOM   380  C CB  . HIS A 1 53  ? 22.927 -10.474 8.970   1.00 11.26 ? 53  HIS A CB  1 
ATOM   381  C CG  . HIS A 1 53  ? 22.572 -10.607 10.424  1.00 15.67 ? 53  HIS A CG  1 
ATOM   382  N ND1 . HIS A 1 53  ? 23.509 -10.850 11.407  1.00 12.17 ? 53  HIS A ND1 1 
ATOM   383  C CD2 . HIS A 1 53  ? 21.395 -10.412 11.069  1.00 14.55 ? 53  HIS A CD2 1 
ATOM   384  C CE1 . HIS A 1 53  ? 22.919 -10.843 12.590  1.00 15.03 ? 53  HIS A CE1 1 
ATOM   385  N NE2 . HIS A 1 53  ? 21.635 -10.579 12.412  1.00 17.57 ? 53  HIS A NE2 1 
ATOM   386  N N   . PHE A 1 54  ? 22.501 -13.938 9.208   1.00 10.54 ? 54  PHE A N   1 
ATOM   387  C CA  . PHE A 1 54  ? 21.642 -15.065 9.583   1.00 11.77 ? 54  PHE A CA  1 
ATOM   388  C C   . PHE A 1 54  ? 21.915 -15.373 11.052  1.00 12.59 ? 54  PHE A C   1 
ATOM   389  O O   . PHE A 1 54  ? 23.015 -15.812 11.404  1.00 12.28 ? 54  PHE A O   1 
ATOM   390  C CB  . PHE A 1 54  ? 21.909 -16.290 8.688   1.00 10.05 ? 54  PHE A CB  1 
ATOM   391  C CG  . PHE A 1 54  ? 21.123 -17.540 9.055   1.00 10.90 ? 54  PHE A CG  1 
ATOM   392  C CD1 . PHE A 1 54  ? 19.804 -17.701 8.651   1.00 16.79 ? 54  PHE A CD1 1 
ATOM   393  C CD2 . PHE A 1 54  ? 21.724 -18.581 9.753   1.00 13.15 ? 54  PHE A CD2 1 
ATOM   394  C CE1 . PHE A 1 54  ? 19.086 -18.861 8.975   1.00 12.97 ? 54  PHE A CE1 1 
ATOM   395  C CE2 . PHE A 1 54  ? 21.016 -19.747 10.074  1.00 12.77 ? 54  PHE A CE2 1 
ATOM   396  C CZ  . PHE A 1 54  ? 19.695 -19.884 9.689   1.00 11.56 ? 54  PHE A CZ  1 
ATOM   397  N N   . GLN A 1 55  ? 20.928 -15.131 11.913  1.00 11.56 ? 55  GLN A N   1 
ATOM   398  C CA  . GLN A 1 55  ? 21.127 -15.211 13.354  1.00 10.45 ? 55  GLN A CA  1 
ATOM   399  C C   . GLN A 1 55  ? 20.069 -16.114 13.956  1.00 13.08 ? 55  GLN A C   1 
ATOM   400  O O   . GLN A 1 55  ? 18.876 -15.797 13.887  1.00 15.88 ? 55  GLN A O   1 
ATOM   401  C CB  . GLN A 1 55  ? 21.036 -13.835 13.999  1.00 12.64 ? 55  GLN A CB  1 
ATOM   402  C CG  . GLN A 1 55  ? 21.458 -13.826 15.446  1.00 14.87 ? 55  GLN A CG  1 
ATOM   403  C CD  . GLN A 1 55  ? 21.256 -12.476 16.041  1.00 19.44 ? 55  GLN A CD  1 
ATOM   404  O OE1 . GLN A 1 55  ? 20.141 -12.146 16.450  1.00 23.54 ? 55  GLN A OE1 1 
ATOM   405  N NE2 . GLN A 1 55  ? 22.300 -11.672 16.080  1.00 21.82 ? 55  GLN A NE2 1 
ATOM   406  N N   . VAL A 1 56  ? 20.503 -17.205 14.576  1.00 12.64 ? 56  VAL A N   1 
ATOM   407  C CA  . VAL A 1 56  ? 19.597 -18.171 15.179  1.00 12.74 ? 56  VAL A CA  1 
ATOM   408  C C   . VAL A 1 56  ? 19.643 -17.966 16.685  1.00 15.10 ? 56  VAL A C   1 
ATOM   409  O O   . VAL A 1 56  ? 20.726 -17.959 17.280  1.00 16.43 ? 56  VAL A O   1 
ATOM   410  C CB  . VAL A 1 56  ? 19.997 -19.616 14.834  1.00 15.62 ? 56  VAL A CB  1 
ATOM   411  C CG1 . VAL A 1 56  ? 19.036 -20.598 15.488  1.00 15.17 ? 56  VAL A CG1 1 
ATOM   412  C CG2 . VAL A 1 56  ? 20.121 -19.835 13.329  1.00 13.90 ? 56  VAL A CG2 1 
ATOM   413  N N   . CYS A 1 57  ? 18.484 -17.782 17.300  1.00 15.13 ? 57  CYS A N   1 
ATOM   414  C CA  . CYS A 1 57  ? 18.339 -17.926 18.747  1.00 17.04 ? 57  CYS A CA  1 
ATOM   415  C C   . CYS A 1 57  ? 17.710 -19.298 18.956  1.00 15.70 ? 57  CYS A C   1 
ATOM   416  O O   . CYS A 1 57  ? 16.495 -19.450 18.831  1.00 18.74 ? 57  CYS A O   1 
ATOM   417  C CB  . CYS A 1 57  ? 17.490 -16.810 19.342  1.00 22.26 ? 57  CYS A CB  1 
ATOM   418  S SG  . CYS A 1 57  ? 17.308 -16.965 21.142  1.00 33.13 ? 57  CYS A SG  1 
ATOM   419  N N   . PHE A 1 58  ? 18.548 -20.301 19.218  1.00 15.42 ? 58  PHE A N   1 
ATOM   420  C CA  . PHE A 1 58  ? 18.128 -21.702 19.194  1.00 16.54 ? 58  PHE A CA  1 
ATOM   421  C C   . PHE A 1 58  ? 16.900 -21.931 20.066  1.00 19.27 ? 58  PHE A C   1 
ATOM   422  O O   . PHE A 1 58  ? 16.856 -21.505 21.222  1.00 17.88 ? 58  PHE A O   1 
ATOM   423  C CB  . PHE A 1 58  ? 19.282 -22.585 19.660  1.00 15.87 ? 58  PHE A CB  1 
ATOM   424  C CG  . PHE A 1 58  ? 20.334 -22.834 18.598  1.00 14.59 ? 58  PHE A CG  1 
ATOM   425  C CD1 . PHE A 1 58  ? 20.057 -23.609 17.478  1.00 16.46 ? 58  PHE A CD1 1 
ATOM   426  C CD2 . PHE A 1 58  ? 21.580 -22.227 18.692  1.00 13.44 ? 58  PHE A CD2 1 
ATOM   427  C CE1 . PHE A 1 58  ? 21.026 -23.827 16.510  1.00 15.66 ? 58  PHE A CE1 1 
ATOM   428  C CE2 . PHE A 1 58  ? 22.547 -22.424 17.713  1.00 13.79 ? 58  PHE A CE2 1 
ATOM   429  C CZ  . PHE A 1 58  ? 22.271 -23.225 16.626  1.00 14.86 ? 58  PHE A CZ  1 
ATOM   430  N N   . GLY A 1 59  ? 15.888 -22.570 19.479  1.00 21.54 ? 59  GLY A N   1 
ATOM   431  C CA  . GLY A 1 59  ? 14.636 -22.832 20.152  1.00 22.26 ? 59  GLY A CA  1 
ATOM   432  C C   . GLY A 1 59  ? 13.638 -21.693 20.168  1.00 24.46 ? 59  GLY A C   1 
ATOM   433  O O   . GLY A 1 59  ? 12.517 -21.889 20.656  1.00 23.07 ? 59  GLY A O   1 
ATOM   434  N N   . ARG A 1 60  ? 13.994 -20.507 19.667  1.00 19.71 ? 60  ARG A N   1 
ATOM   435  C CA  . ARG A 1 60  ? 13.096 -19.351 19.736  1.00 19.77 ? 60  ARG A CA  1 
ATOM   436  C C   . ARG A 1 60  ? 12.825 -18.755 18.365  1.00 23.45 ? 60  ARG A C   1 
ATOM   437  O O   . ARG A 1 60  ? 11.690 -18.825 17.885  1.00 20.31 ? 60  ARG A O   1 
ATOM   438  C CB  . ARG A 1 60  ? 13.650 -18.300 20.696  1.00 21.34 ? 60  ARG A CB  1 
ATOM   439  N N   . ARG A 1 61  ? 13.810 -18.135 17.716  1.00 19.16 ? 61  ARG A N   1 
ATOM   440  C CA  . ARG A 1 61  ? 13.544 -17.486 16.443  1.00 19.44 ? 61  ARG A CA  1 
ATOM   441  C C   . ARG A 1 61  ? 14.817 -17.438 15.613  1.00 18.96 ? 61  ARG A C   1 
ATOM   442  O O   . ARG A 1 61  ? 15.914 -17.731 16.096  1.00 14.78 ? 61  ARG A O   1 
ATOM   443  C CB  . ARG A 1 61  ? 13.031 -16.056 16.615  1.00 21.85 ? 61  ARG A CB  1 
ATOM   444  C CG  . ARG A 1 61  ? 13.987 -15.180 17.410  1.00 27.92 ? 61  ARG A CG  1 
ATOM   445  C CD  . ARG A 1 61  ? 13.604 -13.712 17.332  1.00 32.61 ? 61  ARG A CD  1 
ATOM   446  N NE  . ARG A 1 61  ? 14.739 -12.857 17.681  1.00 41.66 ? 61  ARG A NE  1 
ATOM   447  C CZ  . ARG A 1 61  ? 14.701 -11.528 17.702  1.00 37.18 ? 61  ARG A CZ  1 
ATOM   448  N NH1 . ARG A 1 61  ? 13.589 -10.888 17.356  1.00 38.56 ? 61  ARG A NH1 1 
ATOM   449  N NH2 . ARG A 1 61  ? 15.786 -10.835 18.032  1.00 38.87 ? 61  ARG A NH2 1 
ATOM   450  N N   . VAL A 1 62  ? 14.645 -17.031 14.357  1.00 14.99 ? 62  VAL A N   1 
ATOM   451  C CA  . VAL A 1 62  ? 15.730 -16.677 13.452  1.00 14.75 ? 62  VAL A CA  1 
ATOM   452  C C   . VAL A 1 62  ? 15.445 -15.291 12.898  1.00 18.88 ? 62  VAL A C   1 
ATOM   453  O O   . VAL A 1 62  ? 14.300 -14.982 12.549  1.00 18.23 ? 62  VAL A O   1 
ATOM   454  C CB  . VAL A 1 62  ? 15.859 -17.699 12.305  1.00 14.83 ? 62  VAL A CB  1 
ATOM   455  C CG1 . VAL A 1 62  ? 16.814 -17.178 11.222  1.00 16.19 ? 62  VAL A CG1 1 
ATOM   456  C CG2 . VAL A 1 62  ? 16.342 -19.020 12.842  1.00 19.63 ? 62  VAL A CG2 1 
ATOM   457  N N   . VAL A 1 63  ? 16.473 -14.446 12.830  1.00 15.12 ? 63  VAL A N   1 
ATOM   458  C CA  . VAL A 1 63  ? 16.356 -13.160 12.158  1.00 17.64 ? 63  VAL A CA  1 
ATOM   459  C C   . VAL A 1 63  ? 17.381 -13.092 11.037  1.00 18.06 ? 63  VAL A C   1 
ATOM   460  O O   . VAL A 1 63  ? 18.511 -13.584 11.172  1.00 14.07 ? 63  VAL A O   1 
ATOM   461  C CB  . VAL A 1 63  ? 16.502 -11.957 13.114  1.00 21.52 ? 63  VAL A CB  1 
ATOM   462  C CG1 . VAL A 1 63  ? 15.418 -11.999 14.186  1.00 24.60 ? 63  VAL A CG1 1 
ATOM   463  C CG2 . VAL A 1 63  ? 17.870 -11.933 13.749  1.00 20.23 ? 63  VAL A CG2 1 
ATOM   464  N N   . MET A 1 64  ? 16.966 -12.499 9.920   1.00 13.32 ? 64  MET A N   1 
ATOM   465  C CA  . MET A 1 64  ? 17.855 -12.241 8.801   1.00 11.71 ? 64  MET A CA  1 
ATOM   466  C C   . MET A 1 64  ? 17.763 -10.769 8.425   1.00 14.90 ? 64  MET A C   1 
ATOM   467  O O   . MET A 1 64  ? 16.707 -10.135 8.568   1.00 15.40 ? 64  MET A O   1 
ATOM   468  C CB  . MET A 1 64  ? 17.548 -13.115 7.569   1.00 14.60 ? 64  MET A CB  1 
ATOM   469  C CG  . MET A 1 64  ? 17.810 -14.619 7.782   1.00 12.59 ? 64  MET A CG  1 
ATOM   470  S SD  . MET A 1 64  ? 16.894 -15.664 6.645   1.00 14.97 ? 64  MET A SD  1 
ATOM   471  C CE  . MET A 1 64  ? 15.278 -15.696 7.441   1.00 17.11 ? 64  MET A CE  1 
ATOM   472  N N   . ASN A 1 65  ? 18.876 -10.222 7.960   1.00 11.25 ? 65  ASN A N   1 
ATOM   473  C CA  . ASN A 1 65  ? 18.924 -8.798  7.653   1.00 13.64 ? 65  ASN A CA  1 
ATOM   474  C C   . ASN A 1 65  ? 20.163 -8.537  6.802   1.00 12.70 ? 65  ASN A C   1 
ATOM   475  O O   . ASN A 1 65  ? 20.914 -9.453  6.454   1.00 12.18 ? 65  ASN A O   1 
ATOM   476  C CB  . ASN A 1 65  ? 18.935 -7.973  8.942   1.00 13.86 ? 65  ASN A CB  1 
ATOM   477  C CG  . ASN A 1 65  ? 18.345 -6.594  8.761   1.00 18.76 ? 65  ASN A CG  1 
ATOM   478  O OD1 . ASN A 1 65  ? 18.174 -6.109  7.637   1.00 15.56 ? 65  ASN A OD1 1 
ATOM   479  N ND2 . ASN A 1 65  ? 17.999 -5.960  9.877   1.00 18.15 ? 65  ASN A ND2 1 
ATOM   480  N N   . SER A 1 66  ? 20.357 -7.273  6.455   1.00 13.22 ? 66  SER A N   1 
ATOM   481  C CA  . SER A 1 66  ? 21.584 -6.814  5.835   1.00 14.03 ? 66  SER A CA  1 
ATOM   482  C C   . SER A 1 66  ? 22.021 -5.564  6.571   1.00 13.41 ? 66  SER A C   1 
ATOM   483  O O   . SER A 1 66  ? 21.200 -4.854  7.145   1.00 15.17 ? 66  SER A O   1 
ATOM   484  C CB  . SER A 1 66  ? 21.407 -6.528  4.331   1.00 13.66 ? 66  SER A CB  1 
ATOM   485  O OG  . SER A 1 66  ? 20.389 -5.572  4.118   1.00 14.72 ? 66  SER A OG  1 
ATOM   486  N N   . ARG A 1 67  ? 23.321 -5.306  6.559   1.00 13.08 ? 67  ARG A N   1 
ATOM   487  C CA  . ARG A 1 67  ? 23.880 -4.085  7.125   1.00 14.28 ? 67  ARG A CA  1 
ATOM   488  C C   . ARG A 1 67  ? 24.539 -3.330  5.984   1.00 14.44 ? 67  ARG A C   1 
ATOM   489  O O   . ARG A 1 67  ? 25.552 -3.785  5.436   1.00 14.18 ? 67  ARG A O   1 
ATOM   490  C CB  . ARG A 1 67  ? 24.886 -4.365  8.242   1.00 12.11 ? 67  ARG A CB  1 
ATOM   491  C CG  . ARG A 1 67  ? 25.280 -3.077  8.972   1.00 16.14 ? 67  ARG A CG  1 
ATOM   492  C CD  . ARG A 1 67  ? 26.118 -3.327  10.217  1.00 18.27 ? 67  ARG A CD  1 
ATOM   493  N NE  . ARG A 1 67  ? 27.456 -3.813  9.866   1.00 15.90 ? 67  ARG A NE  1 
ATOM   494  C CZ  . ARG A 1 67  ? 28.200 -4.581  10.651  1.00 18.11 ? 67  ARG A CZ  1 
ATOM   495  N NH1 . ARG A 1 67  ? 27.754 -4.943  11.851  1.00 18.79 ? 67  ARG A NH1 1 
ATOM   496  N NH2 . ARG A 1 67  ? 29.399 -4.975  10.248  1.00 17.17 ? 67  ARG A NH2 1 
ATOM   497  N N   . GLU A 1 68  ? 23.965 -2.186  5.633   1.00 16.75 ? 68  GLU A N   1 
ATOM   498  C CA  . GLU A 1 68  ? 24.325 -1.451  4.424   1.00 17.42 ? 68  GLU A CA  1 
ATOM   499  C C   . GLU A 1 68  ? 24.771 -0.054  4.817   1.00 21.24 ? 68  GLU A C   1 
ATOM   500  O O   . GLU A 1 68  ? 24.077 0.634   5.574   1.00 20.40 ? 68  GLU A O   1 
ATOM   501  C CB  . GLU A 1 68  ? 23.152 -1.408  3.437   1.00 21.80 ? 68  GLU A CB  1 
ATOM   502  C CG  . GLU A 1 68  ? 22.546 -2.785  3.182   1.00 18.66 ? 68  GLU A CG  1 
ATOM   503  C CD  . GLU A 1 68  ? 21.398 -2.772  2.187   1.00 25.99 ? 68  GLU A CD  1 
ATOM   504  O OE1 . GLU A 1 68  ? 21.330 -1.831  1.367   1.00 24.54 ? 68  GLU A OE1 1 
ATOM   505  O OE2 . GLU A 1 68  ? 20.584 -3.728  2.200   1.00 21.47 ? 68  GLU A OE2 1 
ATOM   506  N N   . TYR A 1 69  ? 25.938 0.339   4.319   1.00 19.73 ? 69  TYR A N   1 
ATOM   507  C CA  . TYR A 1 69  ? 26.629 1.557   4.741   1.00 21.25 ? 69  TYR A CA  1 
ATOM   508  C C   . TYR A 1 69  ? 26.548 1.763   6.249   1.00 23.73 ? 69  TYR A C   1 
ATOM   509  O O   . TYR A 1 69  ? 26.308 2.863   6.754   1.00 27.54 ? 69  TYR A O   1 
ATOM   510  C CB  . TYR A 1 69  ? 26.117 2.757   3.958   1.00 21.52 ? 69  TYR A CB  1 
ATOM   511  C CG  . TYR A 1 69  ? 26.719 2.692   2.580   1.00 22.97 ? 69  TYR A CG  1 
ATOM   512  C CD1 . TYR A 1 69  ? 27.991 3.202   2.363   1.00 24.86 ? 69  TYR A CD1 1 
ATOM   513  C CD2 . TYR A 1 69  ? 26.060 2.074   1.525   1.00 22.33 ? 69  TYR A CD2 1 
ATOM   514  C CE1 . TYR A 1 69  ? 28.587 3.125   1.139   1.00 28.23 ? 69  TYR A CE1 1 
ATOM   515  C CE2 . TYR A 1 69  ? 26.651 1.994   0.270   1.00 22.68 ? 69  TYR A CE2 1 
ATOM   516  C CZ  . TYR A 1 69  ? 27.919 2.523   0.094   1.00 24.33 ? 69  TYR A CZ  1 
ATOM   517  O OH  . TYR A 1 69  ? 28.561 2.474   -1.116  1.00 30.23 ? 69  TYR A OH  1 
ATOM   518  N N   . GLY A 1 70  ? 26.781 0.672   6.978   1.00 20.97 ? 70  GLY A N   1 
ATOM   519  C CA  . GLY A 1 70  ? 26.912 0.718   8.413   1.00 20.18 ? 70  GLY A CA  1 
ATOM   520  C C   . GLY A 1 70  ? 25.625 0.597   9.202   1.00 21.29 ? 70  GLY A C   1 
ATOM   521  O O   . GLY A 1 70  ? 25.685 0.539   10.436  1.00 24.69 ? 70  GLY A O   1 
ATOM   522  N N   . ALA A 1 71  ? 24.468 0.543   8.548   1.00 19.98 ? 71  ALA A N   1 
ATOM   523  C CA  . ALA A 1 71  ? 23.181 0.554   9.240   1.00 21.26 ? 71  ALA A CA  1 
ATOM   524  C C   . ALA A 1 71  ? 22.372 -0.686  8.893   1.00 19.73 ? 71  ALA A C   1 
ATOM   525  O O   . ALA A 1 71  ? 22.339 -1.115  7.732   1.00 18.38 ? 71  ALA A O   1 
ATOM   526  C CB  . ALA A 1 71  ? 22.367 1.807   8.890   1.00 25.98 ? 71  ALA A CB  1 
ATOM   527  N N   . TRP A 1 72  ? 21.713 -1.256  9.905   1.00 17.38 ? 72  TRP A N   1 
ATOM   528  C CA  . TRP A 1 72  ? 20.876 -2.424  9.679   1.00 19.21 ? 72  TRP A CA  1 
ATOM   529  C C   . TRP A 1 72  ? 19.608 -2.042  8.924   1.00 21.19 ? 72  TRP A C   1 
ATOM   530  O O   . TRP A 1 72  ? 19.037 -0.967  9.119   1.00 20.77 ? 72  TRP A O   1 
ATOM   531  C CB  . TRP A 1 72  ? 20.523 -3.101  11.000  1.00 18.70 ? 72  TRP A CB  1 
ATOM   532  C CG  . TRP A 1 72  ? 21.687 -3.824  11.607  1.00 18.92 ? 72  TRP A CG  1 
ATOM   533  C CD1 . TRP A 1 72  ? 22.437 -3.437  12.676  1.00 19.76 ? 72  TRP A CD1 1 
ATOM   534  C CD2 . TRP A 1 72  ? 22.242 -5.060  11.151  1.00 17.47 ? 72  TRP A CD2 1 
ATOM   535  N NE1 . TRP A 1 72  ? 23.422 -4.366  12.921  1.00 20.89 ? 72  TRP A NE1 1 
ATOM   536  C CE2 . TRP A 1 72  ? 23.322 -5.369  11.991  1.00 20.60 ? 72  TRP A CE2 1 
ATOM   537  C CE3 . TRP A 1 72  ? 21.932 -5.929  10.100  1.00 17.89 ? 72  TRP A CE3 1 
ATOM   538  C CZ2 . TRP A 1 72  ? 24.082 -6.516  11.827  1.00 18.13 ? 72  TRP A CZ2 1 
ATOM   539  C CZ3 . TRP A 1 72  ? 22.690 -7.057  9.933   1.00 16.59 ? 72  TRP A CZ3 1 
ATOM   540  C CH2 . TRP A 1 72  ? 23.753 -7.346  10.790  1.00 17.89 ? 72  TRP A CH2 1 
ATOM   541  N N   . LYS A 1 73  ? 19.163 -2.940  8.055   1.00 18.95 ? 73  LYS A N   1 
ATOM   542  C CA  . LYS A 1 73  ? 17.981 -2.641  7.260   1.00 20.11 ? 73  LYS A CA  1 
ATOM   543  C C   . LYS A 1 73  ? 16.753 -3.349  7.828   1.00 20.22 ? 73  LYS A C   1 
ATOM   544  O O   . LYS A 1 73  ? 16.669 -3.569  9.039   1.00 21.60 ? 73  LYS A O   1 
ATOM   545  C CB  . LYS A 1 73  ? 18.240 -3.010  5.800   1.00 22.49 ? 73  LYS A CB  1 
ATOM   546  C CG  . LYS A 1 73  ? 19.211 -2.059  5.108   1.00 23.52 ? 73  LYS A CG  1 
ATOM   547  C CD  . LYS A 1 73  ? 18.537 -0.706  4.814   1.00 31.08 ? 73  LYS A CD  1 
ATOM   548  C CE  . LYS A 1 73  ? 19.473 0.261   4.081   1.00 34.25 ? 73  LYS A CE  1 
ATOM   549  N NZ  . LYS A 1 73  ? 20.134 1.210   5.037   1.00 38.53 ? 73  LYS A NZ  1 
ATOM   550  N N   . GLN A 1 74  ? 15.792 -3.681  6.970   1.00 22.75 ? 74  GLN A N   1 
ATOM   551  C CA  . GLN A 1 74  ? 14.545 -4.335  7.373   1.00 26.72 ? 74  GLN A CA  1 
ATOM   552  C C   . GLN A 1 74  ? 14.800 -5.772  7.804   1.00 21.33 ? 74  GLN A C   1 
ATOM   553  O O   . GLN A 1 74  ? 15.208 -6.587  6.976   1.00 21.05 ? 74  GLN A O   1 
ATOM   554  C CB  . GLN A 1 74  ? 13.593 -4.327  6.178   1.00 30.17 ? 74  GLN A CB  1 
ATOM   555  C CG  . GLN A 1 74  ? 12.261 -5.032  6.349   1.00 34.54 ? 74  GLN A CG  1 
ATOM   556  C CD  . GLN A 1 74  ? 11.208 -4.170  7.001   1.00 39.44 ? 74  GLN A CD  1 
ATOM   557  O OE1 . GLN A 1 74  ? 11.496 -3.372  7.895   1.00 43.11 ? 74  GLN A OE1 1 
ATOM   558  N NE2 . GLN A 1 74  ? 9.978  -4.278  6.501   1.00 47.79 ? 74  GLN A NE2 1 
ATOM   559  N N   . GLN A 1 75  ? 14.530 -6.128  9.063   1.00 22.43 ? 75  GLN A N   1 
ATOM   560  C CA  . GLN A 1 75  ? 14.811 -7.519  9.388   1.00 19.77 ? 75  GLN A CA  1 
ATOM   561  C C   . GLN A 1 75  ? 13.643 -8.398  8.979   1.00 22.17 ? 75  GLN A C   1 
ATOM   562  O O   . GLN A 1 75  ? 12.490 -7.960  8.902   1.00 20.04 ? 75  GLN A O   1 
ATOM   563  C CB  . GLN A 1 75  ? 15.116 -7.798  10.865  1.00 25.69 ? 75  GLN A CB  1 
ATOM   564  C CG  . GLN A 1 75  ? 14.004 -7.629  11.847  1.00 24.44 ? 75  GLN A CG  1 
ATOM   565  C CD  . GLN A 1 75  ? 14.401 -8.072  13.264  1.00 31.15 ? 75  GLN A CD  1 
ATOM   566  O OE1 . GLN A 1 75  ? 15.586 -8.168  13.609  1.00 27.86 ? 75  GLN A OE1 1 
ATOM   567  N NE2 . GLN A 1 75  ? 13.398 -8.367  14.080  1.00 27.19 ? 75  GLN A NE2 1 
ATOM   568  N N   . VAL A 1 76  ? 13.973 -9.647  8.679   1.00 16.38 ? 76  VAL A N   1 
ATOM   569  C CA  . VAL A 1 76  ? 13.007 -10.706 8.434   1.00 18.50 ? 76  VAL A CA  1 
ATOM   570  C C   . VAL A 1 76  ? 13.116 -11.638 9.627   1.00 23.32 ? 76  VAL A C   1 
ATOM   571  O O   . VAL A 1 76  ? 14.201 -12.159 9.910   1.00 19.56 ? 76  VAL A O   1 
ATOM   572  C CB  . VAL A 1 76  ? 13.299 -11.445 7.119   1.00 18.26 ? 76  VAL A CB  1 
ATOM   573  C CG1 . VAL A 1 76  ? 12.326 -12.593 6.911   1.00 19.59 ? 76  VAL A CG1 1 
ATOM   574  C CG2 . VAL A 1 76  ? 13.266 -10.481 5.959   1.00 22.32 ? 76  VAL A CG2 1 
ATOM   575  N N   . GLU A 1 77  ? 12.020 -11.806 10.361  1.00 20.80 ? 77  GLU A N   1 
ATOM   576  C CA  . GLU A 1 77  ? 11.996 -12.665 11.542  1.00 20.66 ? 77  GLU A CA  1 
ATOM   577  C C   . GLU A 1 77  ? 11.194 -13.917 11.247  1.00 22.38 ? 77  GLU A C   1 
ATOM   578  O O   . GLU A 1 77  ? 10.070 -13.830 10.749  1.00 25.63 ? 77  GLU A O   1 
ATOM   579  C CB  . GLU A 1 77  ? 11.379 -11.960 12.747  1.00 24.97 ? 77  GLU A CB  1 
ATOM   580  C CG  . GLU A 1 77  ? 11.379 -12.864 13.973  1.00 29.85 ? 77  GLU A CG  1 
ATOM   581  C CD  . GLU A 1 77  ? 10.669 -12.251 15.158  1.00 38.27 ? 77  GLU A CD  1 
ATOM   582  O OE1 . GLU A 1 77  ? 11.346 -11.728 16.064  1.00 39.80 ? 77  GLU A OE1 1 
ATOM   583  O OE2 . GLU A 1 77  ? 9.418  -12.279 15.162  1.00 46.91 ? 77  GLU A OE2 1 
ATOM   584  N N   . SER A 1 78  ? 11.755 -15.070 11.576  1.00 18.31 ? 78  SER A N   1 
ATOM   585  C CA  . SER A 1 78  ? 11.090 -16.345 11.378  1.00 18.80 ? 78  SER A CA  1 
ATOM   586  C C   . SER A 1 78  ? 11.027 -17.090 12.709  1.00 25.51 ? 78  SER A C   1 
ATOM   587  O O   . SER A 1 78  ? 11.973 -17.043 13.507  1.00 21.54 ? 78  SER A O   1 
ATOM   588  C CB  . SER A 1 78  ? 11.827 -17.168 10.328  1.00 16.61 ? 78  SER A CB  1 
ATOM   589  O OG  . SER A 1 78  ? 11.358 -18.492 10.287  1.00 19.35 ? 78  SER A OG  1 
ATOM   590  N N   . LYS A 1 79  ? 9.895  -17.741 12.958  1.00 22.08 ? 79  LYS A N   1 
ATOM   591  C CA  . LYS A 1 79  ? 9.723  -18.649 14.087  1.00 21.95 ? 79  LYS A CA  1 
ATOM   592  C C   . LYS A 1 79  ? 9.969  -20.102 13.708  1.00 21.15 ? 79  LYS A C   1 
ATOM   593  O O   . LYS A 1 79  ? 9.894  -20.981 14.572  1.00 20.31 ? 79  LYS A O   1 
ATOM   594  C CB  . LYS A 1 79  ? 8.316  -18.506 14.670  1.00 24.19 ? 79  LYS A CB  1 
ATOM   595  C CG  . LYS A 1 79  ? 8.036  -17.173 15.323  1.00 27.54 ? 79  LYS A CG  1 
ATOM   596  C CD  . LYS A 1 79  ? 9.130  -16.824 16.309  1.00 28.89 ? 79  LYS A CD  1 
ATOM   597  C CE  . LYS A 1 79  ? 8.631  -15.792 17.303  1.00 38.67 ? 79  LYS A CE  1 
ATOM   598  N NZ  . LYS A 1 79  ? 8.358  -14.481 16.659  1.00 34.93 ? 79  LYS A NZ  1 
ATOM   599  N N   . ASN A 1 80  ? 10.253 -20.371 12.444  1.00 17.94 ? 80  ASN A N   1 
ATOM   600  C CA  . ASN A 1 80  ? 10.596 -21.720 12.024  1.00 17.09 ? 80  ASN A CA  1 
ATOM   601  C C   . ASN A 1 80  ? 11.860 -22.185 12.739  1.00 19.71 ? 80  ASN A C   1 
ATOM   602  O O   . ASN A 1 80  ? 12.838 -21.443 12.827  1.00 16.46 ? 80  ASN A O   1 
ATOM   603  C CB  . ASN A 1 80  ? 10.795 -21.734 10.516  1.00 18.64 ? 80  ASN A CB  1 
ATOM   604  C CG  . ASN A 1 80  ? 10.918 -23.118 9.972   1.00 20.54 ? 80  ASN A CG  1 
ATOM   605  O OD1 . ASN A 1 80  ? 10.422 -24.063 10.564  1.00 22.94 ? 80  ASN A OD1 1 
ATOM   606  N ND2 . ASN A 1 80  ? 11.575 -23.253 8.831   1.00 19.99 ? 80  ASN A ND2 1 
ATOM   607  N N   . MET A 1 81  ? 11.855 -23.410 13.271  1.00 18.29 ? 81  MET A N   1 
ATOM   608  C CA  . MET A 1 81  ? 12.958 -23.862 14.118  1.00 21.37 ? 81  MET A CA  1 
ATOM   609  C C   . MET A 1 81  ? 13.202 -25.361 13.898  1.00 18.71 ? 81  MET A C   1 
ATOM   610  O O   . MET A 1 81  ? 12.888 -26.193 14.746  1.00 23.15 ? 81  MET A O   1 
ATOM   611  C CB  . MET A 1 81  ? 12.670 -23.518 15.581  1.00 22.47 ? 81  MET A CB  1 
ATOM   612  C CG  . MET A 1 81  ? 13.753 -23.855 16.617  1.00 23.89 ? 81  MET A CG  1 
ATOM   613  S SD  . MET A 1 81  ? 15.331 -23.067 16.178  1.00 19.05 ? 81  MET A SD  1 
ATOM   614  C CE  . MET A 1 81  ? 14.981 -21.337 16.393  1.00 19.24 ? 81  MET A CE  1 
ATOM   615  N N   . PRO A 1 82  ? 13.795 -25.709 12.755  1.00 19.27 ? 82  PRO A N   1 
ATOM   616  C CA  . PRO A 1 82  ? 14.124 -27.125 12.516  1.00 20.06 ? 82  PRO A CA  1 
ATOM   617  C C   . PRO A 1 82  ? 15.278 -27.635 13.359  1.00 23.98 ? 82  PRO A C   1 
ATOM   618  O O   . PRO A 1 82  ? 15.452 -28.858 13.440  1.00 21.03 ? 82  PRO A O   1 
ATOM   619  C CB  . PRO A 1 82  ? 14.487 -27.153 11.027  1.00 20.07 ? 82  PRO A CB  1 
ATOM   620  C CG  . PRO A 1 82  ? 14.997 -25.767 10.753  1.00 17.94 ? 82  PRO A CG  1 
ATOM   621  C CD  . PRO A 1 82  ? 14.208 -24.844 11.640  1.00 18.73 ? 82  PRO A CD  1 
ATOM   622  N N   . PHE A 1 83  ? 16.090 -26.762 13.957  1.00 16.05 ? 83  PHE A N   1 
ATOM   623  C CA  . PHE A 1 83  ? 17.218 -27.249 14.748  1.00 19.95 ? 83  PHE A CA  1 
ATOM   624  C C   . PHE A 1 83  ? 16.709 -28.047 15.942  1.00 18.66 ? 83  PHE A C   1 
ATOM   625  O O   . PHE A 1 83  ? 15.682 -27.710 16.532  1.00 18.11 ? 83  PHE A O   1 
ATOM   626  C CB  . PHE A 1 83  ? 18.099 -26.090 15.231  1.00 18.96 ? 83  PHE A CB  1 
ATOM   627  C CG  . PHE A 1 83  ? 18.669 -25.249 14.116  1.00 17.55 ? 83  PHE A CG  1 
ATOM   628  C CD1 . PHE A 1 83  ? 19.888 -25.584 13.536  1.00 16.66 ? 83  PHE A CD1 1 
ATOM   629  C CD2 . PHE A 1 83  ? 17.999 -24.122 13.664  1.00 18.18 ? 83  PHE A CD2 1 
ATOM   630  C CE1 . PHE A 1 83  ? 20.428 -24.817 12.507  1.00 14.69 ? 83  PHE A CE1 1 
ATOM   631  C CE2 . PHE A 1 83  ? 18.538 -23.341 12.639  1.00 14.45 ? 83  PHE A CE2 1 
ATOM   632  C CZ  . PHE A 1 83  ? 19.748 -23.700 12.064  1.00 15.79 ? 83  PHE A CZ  1 
ATOM   633  N N   . GLN A 1 84  ? 17.449 -29.091 16.311  1.00 20.45 ? 84  GLN A N   1 
ATOM   634  C CA  . GLN A 1 84  ? 17.065 -30.001 17.388  1.00 23.28 ? 84  GLN A CA  1 
ATOM   635  C C   . GLN A 1 84  ? 17.947 -29.811 18.621  1.00 22.44 ? 84  GLN A C   1 
ATOM   636  O O   . GLN A 1 84  ? 19.179 -29.774 18.512  1.00 20.07 ? 84  GLN A O   1 
ATOM   637  C CB  . GLN A 1 84  ? 17.131 -31.458 16.909  1.00 23.89 ? 84  GLN A CB  1 
ATOM   638  C CG  . GLN A 1 84  ? 16.262 -31.712 15.695  1.00 25.70 ? 84  GLN A CG  1 
ATOM   639  C CD  . GLN A 1 84  ? 14.795 -31.605 16.051  1.00 30.70 ? 84  GLN A CD  1 
ATOM   640  O OE1 . GLN A 1 84  ? 14.129 -30.630 15.698  1.00 35.64 ? 84  GLN A OE1 1 
ATOM   641  N NE2 . GLN A 1 84  ? 14.287 -32.593 16.774  1.00 32.65 ? 84  GLN A NE2 1 
ATOM   642  N N   . ASP A 1 85  ? 17.306 -29.724 19.788  1.00 23.01 ? 85  ASP A N   1 
ATOM   643  C CA  . ASP A 1 85  ? 18.004 -29.530 21.061  1.00 24.19 ? 85  ASP A CA  1 
ATOM   644  C C   . ASP A 1 85  ? 19.132 -30.539 21.256  1.00 25.03 ? 85  ASP A C   1 
ATOM   645  O O   . ASP A 1 85  ? 18.925 -31.751 21.162  1.00 26.58 ? 85  ASP A O   1 
ATOM   646  C CB  . ASP A 1 85  ? 16.996 -29.631 22.209  1.00 21.96 ? 85  ASP A CB  1 
ATOM   647  C CG  . ASP A 1 85  ? 17.474 -28.949 23.489  1.00 23.24 ? 85  ASP A CG  1 
ATOM   648  O OD1 . ASP A 1 85  ? 18.640 -28.506 23.553  1.00 23.37 ? 85  ASP A OD1 1 
ATOM   649  O OD2 . ASP A 1 85  ? 16.676 -28.862 24.444  1.00 24.44 ? 85  ASP A OD2 1 
ATOM   650  N N   . GLY A 1 86  ? 20.335 -30.022 21.518  1.00 24.60 ? 86  GLY A N   1 
ATOM   651  C CA  . GLY A 1 86  ? 21.485 -30.835 21.856  1.00 21.63 ? 86  GLY A CA  1 
ATOM   652  C C   . GLY A 1 86  ? 22.155 -31.537 20.699  1.00 28.69 ? 86  GLY A C   1 
ATOM   653  O O   . GLY A 1 86  ? 23.109 -32.287 20.930  1.00 26.50 ? 86  GLY A O   1 
ATOM   654  N N   . GLN A 1 87  ? 21.711 -31.307 19.465  1.00 22.97 ? 87  GLN A N   1 
ATOM   655  C CA  . GLN A 1 87  ? 22.161 -32.083 18.318  1.00 24.18 ? 87  GLN A CA  1 
ATOM   656  C C   . GLN A 1 87  ? 23.108 -31.280 17.441  1.00 23.84 ? 87  GLN A C   1 
ATOM   657  O O   . GLN A 1 87  ? 23.023 -30.052 17.351  1.00 21.26 ? 87  GLN A O   1 
ATOM   658  C CB  . GLN A 1 87  ? 20.980 -32.555 17.458  1.00 22.06 ? 87  GLN A CB  1 
ATOM   659  C CG  . GLN A 1 87  ? 19.928 -33.325 18.228  1.00 25.99 ? 87  GLN A CG  1 
ATOM   660  C CD  . GLN A 1 87  ? 20.550 -34.428 19.057  1.00 28.66 ? 87  GLN A CD  1 
ATOM   661  O OE1 . GLN A 1 87  ? 21.164 -35.347 18.518  1.00 31.74 ? 87  GLN A OE1 1 
ATOM   662  N NE2 . GLN A 1 87  ? 20.377 -34.353 20.379  1.00 31.74 ? 87  GLN A NE2 1 
ATOM   663  N N   . GLU A 1 88  ? 24.012 -32.001 16.795  1.00 21.11 ? 88  GLU A N   1 
ATOM   664  C CA  . GLU A 1 88  ? 24.756 -31.453 15.677  1.00 26.59 ? 88  GLU A CA  1 
ATOM   665  C C   . GLU A 1 88  ? 23.783 -31.032 14.577  1.00 23.59 ? 88  GLU A C   1 
ATOM   666  O O   . GLU A 1 88  ? 22.720 -31.631 14.398  1.00 23.79 ? 88  GLU A O   1 
ATOM   667  C CB  . GLU A 1 88  ? 25.742 -32.502 15.161  1.00 26.43 ? 88  GLU A CB  1 
ATOM   668  C CG  . GLU A 1 88  ? 26.617 -32.064 14.002  1.00 32.80 ? 88  GLU A CG  1 
ATOM   669  C CD  . GLU A 1 88  ? 27.985 -32.734 14.023  1.00 44.84 ? 88  GLU A CD  1 
ATOM   670  O OE1 . GLU A 1 88  ? 28.918 -32.206 13.372  1.00 42.86 ? 88  GLU A OE1 1 
ATOM   671  O OE2 . GLU A 1 88  ? 28.131 -33.774 14.706  1.00 48.68 ? 88  GLU A OE2 1 
ATOM   672  N N   . PHE A 1 89  ? 24.131 -29.969 13.861  1.00 16.27 ? 89  PHE A N   1 
ATOM   673  C CA  . PHE A 1 89  ? 23.337 -29.515 12.729  1.00 18.67 ? 89  PHE A CA  1 
ATOM   674  C C   . PHE A 1 89  ? 24.226 -29.403 11.497  1.00 18.39 ? 89  PHE A C   1 
ATOM   675  O O   . PHE A 1 89  ? 25.442 -29.246 11.601  1.00 16.92 ? 89  PHE A O   1 
ATOM   676  C CB  . PHE A 1 89  ? 22.652 -28.171 13.016  1.00 16.65 ? 89  PHE A CB  1 
ATOM   677  C CG  . PHE A 1 89  ? 23.611 -27.067 13.359  1.00 18.87 ? 89  PHE A CG  1 
ATOM   678  C CD1 . PHE A 1 89  ? 24.322 -26.403 12.365  1.00 14.21 ? 89  PHE A CD1 1 
ATOM   679  C CD2 . PHE A 1 89  ? 23.801 -26.692 14.678  1.00 16.83 ? 89  PHE A CD2 1 
ATOM   680  C CE1 . PHE A 1 89  ? 25.208 -25.399 12.680  1.00 19.01 ? 89  PHE A CE1 1 
ATOM   681  C CE2 . PHE A 1 89  ? 24.693 -25.680 15.002  1.00 16.83 ? 89  PHE A CE2 1 
ATOM   682  C CZ  . PHE A 1 89  ? 25.398 -25.037 14.007  1.00 16.29 ? 89  PHE A CZ  1 
ATOM   683  N N   . GLU A 1 90  ? 23.612 -29.513 10.324  1.00 17.60 ? 90  GLU A N   1 
ATOM   684  C CA  . GLU A 1 90  ? 24.299 -29.262 9.066   1.00 18.02 ? 90  GLU A CA  1 
ATOM   685  C C   . GLU A 1 90  ? 23.531 -28.178 8.338   1.00 18.79 ? 90  GLU A C   1 
ATOM   686  O O   . GLU A 1 90  ? 22.357 -28.362 8.005   1.00 21.28 ? 90  GLU A O   1 
ATOM   687  C CB  . GLU A 1 90  ? 24.411 -30.520 8.203   1.00 20.14 ? 90  GLU A CB  1 
ATOM   688  C CG  . GLU A 1 90  ? 25.220 -30.247 6.933   1.00 28.20 ? 90  GLU A CG  1 
ATOM   689  C CD  . GLU A 1 90  ? 25.465 -31.489 6.087   1.00 38.75 ? 90  GLU A CD  1 
ATOM   690  O OE1 . GLU A 1 90  ? 24.939 -32.574 6.431   1.00 38.64 ? 90  GLU A OE1 1 
ATOM   691  O OE2 . GLU A 1 90  ? 26.175 -31.366 5.065   1.00 37.38 ? 90  GLU A OE2 1 
ATOM   692  N N   . LEU A 1 91  ? 24.188 -27.054 8.107   1.00 14.61 ? 91  LEU A N   1 
ATOM   693  C CA  . LEU A 1 91  ? 23.558 -25.867 7.559   1.00 15.68 ? 91  LEU A CA  1 
ATOM   694  C C   . LEU A 1 91  ? 24.128 -25.661 6.165   1.00 19.30 ? 91  LEU A C   1 
ATOM   695  O O   . LEU A 1 91  ? 25.351 -25.618 6.000   1.00 20.35 ? 91  LEU A O   1 
ATOM   696  C CB  . LEU A 1 91  ? 23.857 -24.665 8.465   1.00 19.23 ? 91  LEU A CB  1 
ATOM   697  C CG  . LEU A 1 91  ? 23.216 -23.296 8.292   1.00 24.34 ? 91  LEU A CG  1 
ATOM   698  C CD1 . LEU A 1 91  ? 21.727 -23.375 8.584   1.00 21.28 ? 91  LEU A CD1 1 
ATOM   699  C CD2 . LEU A 1 91  ? 23.890 -22.308 9.220   1.00 19.15 ? 91  LEU A CD2 1 
ATOM   700  N N   . SER A 1 92  ? 23.257 -25.543 5.165   1.00 17.57 ? 92  SER A N   1 
ATOM   701  C CA  . SER A 1 92  ? 23.690 -25.379 3.781   1.00 16.27 ? 92  SER A CA  1 
ATOM   702  C C   . SER A 1 92  ? 22.995 -24.154 3.203   1.00 21.62 ? 92  SER A C   1 
ATOM   703  O O   . SER A 1 92  ? 21.761 -24.128 3.114   1.00 19.54 ? 92  SER A O   1 
ATOM   704  C CB  . SER A 1 92  ? 23.363 -26.642 2.975   1.00 18.57 ? 92  SER A CB  1 
ATOM   705  O OG  . SER A 1 92  ? 23.761 -26.532 1.628   1.00 27.58 ? 92  SER A OG  1 
ATOM   706  N N   . ILE A 1 93  ? 23.777 -23.129 2.855   1.00 13.20 ? 93  ILE A N   1 
ATOM   707  C CA  . ILE A 1 93  ? 23.264 -21.879 2.304   1.00 12.52 ? 93  ILE A CA  1 
ATOM   708  C C   . ILE A 1 93  ? 23.643 -21.853 0.828   1.00 17.58 ? 93  ILE A C   1 
ATOM   709  O O   . ILE A 1 93  ? 24.832 -21.758 0.492   1.00 14.80 ? 93  ILE A O   1 
ATOM   710  C CB  . ILE A 1 93  ? 23.824 -20.651 3.037   1.00 13.95 ? 93  ILE A CB  1 
ATOM   711  C CG1 . ILE A 1 93  ? 23.513 -20.707 4.533   1.00 14.03 ? 93  ILE A CG1 1 
ATOM   712  C CG2 . ILE A 1 93  ? 23.227 -19.361 2.460   1.00 12.95 ? 93  ILE A CG2 1 
ATOM   713  C CD1 . ILE A 1 93  ? 24.383 -19.767 5.355   1.00 14.71 ? 93  ILE A CD1 1 
ATOM   714  N N   . SER A 1 94  ? 22.642 -21.938 -0.054  1.00 15.88 ? 94  SER A N   1 
ATOM   715  C CA  . SER A 1 94  ? 22.850 -21.911 -1.498  1.00 18.01 ? 94  SER A CA  1 
ATOM   716  C C   . SER A 1 94  ? 22.540 -20.535 -2.072  1.00 15.69 ? 94  SER A C   1 
ATOM   717  O O   . SER A 1 94  ? 21.559 -19.893 -1.683  1.00 13.65 ? 94  SER A O   1 
ATOM   718  C CB  . SER A 1 94  ? 21.977 -22.952 -2.213  1.00 17.95 ? 94  SER A CB  1 
ATOM   719  O OG  . SER A 1 94  ? 22.328 -24.263 -1.819  1.00 32.80 ? 94  SER A OG  1 
ATOM   720  N N   . VAL A 1 95  ? 23.359 -20.101 -3.025  1.00 10.78 ? 95  VAL A N   1 
ATOM   721  C CA  . VAL A 1 95  ? 23.142 -18.830 -3.706  1.00 12.42 ? 95  VAL A CA  1 
ATOM   722  C C   . VAL A 1 95  ? 22.345 -19.125 -4.976  1.00 15.11 ? 95  VAL A C   1 
ATOM   723  O O   . VAL A 1 95  ? 22.875 -19.674 -5.942  1.00 14.83 ? 95  VAL A O   1 
ATOM   724  C CB  . VAL A 1 95  ? 24.468 -18.127 -4.017  1.00 15.03 ? 95  VAL A CB  1 
ATOM   725  C CG1 . VAL A 1 95  ? 24.227 -16.753 -4.646  1.00 15.98 ? 95  VAL A CG1 1 
ATOM   726  C CG2 . VAL A 1 95  ? 25.318 -18.024 -2.734  1.00 13.14 ? 95  VAL A CG2 1 
ATOM   727  N N   . LEU A 1 96  ? 21.066 -18.802 -4.960  1.00 15.83 ? 96  LEU A N   1 
ATOM   728  C CA  . LEU A 1 96  ? 20.229 -18.882 -6.152  1.00 16.45 ? 96  LEU A CA  1 
ATOM   729  C C   . LEU A 1 96  ? 20.213 -17.532 -6.847  1.00 17.97 ? 96  LEU A C   1 
ATOM   730  O O   . LEU A 1 96  ? 20.677 -16.522 -6.290  1.00 17.25 ? 96  LEU A O   1 
ATOM   731  C CB  . LEU A 1 96  ? 18.819 -19.343 -5.760  1.00 14.69 ? 96  LEU A CB  1 
ATOM   732  C CG  . LEU A 1 96  ? 18.688 -20.591 -4.898  1.00 16.99 ? 96  LEU A CG  1 
ATOM   733  C CD1 . LEU A 1 96  ? 17.214 -20.920 -4.670  1.00 18.13 ? 96  LEU A CD1 1 
ATOM   734  C CD2 . LEU A 1 96  ? 19.396 -21.765 -5.550  1.00 27.00 ? 96  LEU A CD2 1 
ATOM   735  N N   . PRO A 1 97  ? 19.714 -17.466 -8.093  1.00 19.56 ? 97  PRO A N   1 
ATOM   736  C CA  . PRO A 1 97  ? 19.736 -16.172 -8.793  1.00 17.61 ? 97  PRO A CA  1 
ATOM   737  C C   . PRO A 1 97  ? 19.021 -15.073 -8.037  1.00 20.16 ? 97  PRO A C   1 
ATOM   738  O O   . PRO A 1 97  ? 19.442 -13.912 -8.090  1.00 15.95 ? 97  PRO A O   1 
ATOM   739  C CB  . PRO A 1 97  ? 19.031 -16.478 -10.126 1.00 25.64 ? 97  PRO A CB  1 
ATOM   740  C CG  . PRO A 1 97  ? 19.222 -17.928 -10.336 1.00 25.77 ? 97  PRO A CG  1 
ATOM   741  C CD  . PRO A 1 97  ? 19.240 -18.556 -8.969  1.00 17.78 ? 97  PRO A CD  1 
ATOM   742  N N   . ASP A 1 98  ? 17.942 -15.397 -7.324  1.00 17.05 ? 98  ASP A N   1 
ATOM   743  C CA  . ASP A 1 98  ? 17.133 -14.352 -6.724  1.00 17.03 ? 98  ASP A CA  1 
ATOM   744  C C   . ASP A 1 98  ? 17.244 -14.288 -5.209  1.00 14.76 ? 98  ASP A C   1 
ATOM   745  O O   . ASP A 1 98  ? 16.779 -13.307 -4.617  1.00 13.30 ? 98  ASP A O   1 
ATOM   746  C CB  . ASP A 1 98  ? 15.666 -14.534 -7.135  1.00 20.79 ? 98  ASP A CB  1 
ATOM   747  C CG  . ASP A 1 98  ? 15.520 -14.884 -8.620  1.00 36.39 ? 98  ASP A CG  1 
ATOM   748  O OD1 . ASP A 1 98  ? 15.775 -14.010 -9.491  1.00 33.77 ? 98  ASP A OD1 1 
ATOM   749  O OD2 . ASP A 1 98  ? 15.170 -16.050 -8.921  1.00 37.12 ? 98  ASP A OD2 1 
ATOM   750  N N   . LYS A 1 99  ? 17.862 -15.277 -4.570  1.00 13.50 ? 99  LYS A N   1 
ATOM   751  C CA  . LYS A 1 99  ? 17.793 -15.370 -3.116  1.00 13.15 ? 99  LYS A CA  1 
ATOM   752  C C   . LYS A 1 99  ? 18.839 -16.362 -2.621  1.00 11.89 ? 99  LYS A C   1 
ATOM   753  O O   . LYS A 1 99  ? 19.349 -17.188 -3.383  1.00 13.32 ? 99  LYS A O   1 
ATOM   754  C CB  . LYS A 1 99  ? 16.402 -15.839 -2.660  1.00 12.88 ? 99  LYS A CB  1 
ATOM   755  C CG  . LYS A 1 99  ? 16.183 -17.315 -2.970  1.00 16.32 ? 99  LYS A CG  1 
ATOM   756  C CD  . LYS A 1 99  ? 14.713 -17.776 -2.933  1.00 18.03 ? 99  LYS A CD  1 
ATOM   757  C CE  . LYS A 1 99  ? 14.009 -17.357 -4.205  1.00 22.63 ? 99  LYS A CE  1 
ATOM   758  N NZ  . LYS A 1 99  ? 12.782 -18.146 -4.522  1.00 18.55 ? 99  LYS A NZ  1 
ATOM   759  N N   . TYR A 1 100 ? 19.120 -16.290 -1.316  1.00 12.34 ? 100 TYR A N   1 
ATOM   760  C CA  . TYR A 1 100 ? 19.775 -17.371 -0.597  1.00 12.65 ? 100 TYR A CA  1 
ATOM   761  C C   . TYR A 1 100 ? 18.715 -18.365 -0.159  1.00 14.51 ? 100 TYR A C   1 
ATOM   762  O O   . TYR A 1 100 ? 17.628 -17.967 0.263   1.00 12.75 ? 100 TYR A O   1 
ATOM   763  C CB  . TYR A 1 100 ? 20.518 -16.852 0.639   1.00 10.92 ? 100 TYR A CB  1 
ATOM   764  C CG  . TYR A 1 100 ? 21.621 -15.874 0.318   1.00 10.29 ? 100 TYR A CG  1 
ATOM   765  C CD1 . TYR A 1 100 ? 22.860 -16.320 -0.117  1.00 11.97 ? 100 TYR A CD1 1 
ATOM   766  C CD2 . TYR A 1 100 ? 21.421 -14.512 0.454   1.00 11.02 ? 100 TYR A CD2 1 
ATOM   767  C CE1 . TYR A 1 100 ? 23.871 -15.416 -0.426  1.00 12.85 ? 100 TYR A CE1 1 
ATOM   768  C CE2 . TYR A 1 100 ? 22.412 -13.604 0.162   1.00 11.95 ? 100 TYR A CE2 1 
ATOM   769  C CZ  . TYR A 1 100 ? 23.645 -14.070 -0.275  1.00 12.67 ? 100 TYR A CZ  1 
ATOM   770  O OH  . TYR A 1 100 ? 24.640 -13.183 -0.585  1.00 13.70 ? 100 TYR A OH  1 
ATOM   771  N N   . GLN A 1 101 ? 19.035 -19.651 -0.252  1.00 12.07 ? 101 GLN A N   1 
ATOM   772  C CA  . GLN A 1 101 ? 18.207 -20.708 0.315   1.00 11.86 ? 101 GLN A CA  1 
ATOM   773  C C   . GLN A 1 101 ? 18.979 -21.425 1.410   1.00 13.99 ? 101 GLN A C   1 
ATOM   774  O O   . GLN A 1 101 ? 20.111 -21.869 1.189   1.00 15.22 ? 101 GLN A O   1 
ATOM   775  C CB  . GLN A 1 101 ? 17.774 -21.716 -0.736  1.00 15.16 ? 101 GLN A CB  1 
ATOM   776  C CG  . GLN A 1 101 ? 17.001 -22.883 -0.139  1.00 18.74 ? 101 GLN A CG  1 
ATOM   777  C CD  . GLN A 1 101 ? 16.223 -23.641 -1.191  1.00 18.49 ? 101 GLN A CD  1 
ATOM   778  O OE1 . GLN A 1 101 ? 15.049 -23.943 -1.012  1.00 21.88 ? 101 GLN A OE1 1 
ATOM   779  N NE2 . GLN A 1 101 ? 16.863 -23.911 -2.309  1.00 20.21 ? 101 GLN A NE2 1 
ATOM   780  N N   . VAL A 1 102 ? 18.360 -21.553 2.577   1.00 13.16 ? 102 VAL A N   1 
ATOM   781  C CA  . VAL A 1 102 ? 19.001 -22.105 3.763   1.00 11.72 ? 102 VAL A CA  1 
ATOM   782  C C   . VAL A 1 102 ? 18.377 -23.458 4.058   1.00 15.85 ? 102 VAL A C   1 
ATOM   783  O O   . VAL A 1 102 ? 17.186 -23.540 4.392   1.00 15.39 ? 102 VAL A O   1 
ATOM   784  C CB  . VAL A 1 102 ? 18.865 -21.171 4.975   1.00 12.83 ? 102 VAL A CB  1 
ATOM   785  C CG1 . VAL A 1 102 ? 19.629 -21.743 6.158   1.00 12.92 ? 102 VAL A CG1 1 
ATOM   786  C CG2 . VAL A 1 102 ? 19.378 -19.788 4.648   1.00 14.38 ? 102 VAL A CG2 1 
ATOM   787  N N   . MET A 1 103 ? 19.179 -24.509 3.949   1.00 11.76 ? 103 MET A N   1 
ATOM   788  C CA  . MET A 1 103 ? 18.769 -25.853 4.328   1.00 16.14 ? 103 MET A CA  1 
ATOM   789  C C   . MET A 1 103 ? 19.311 -26.167 5.713   1.00 16.03 ? 103 MET A C   1 
ATOM   790  O O   . MET A 1 103 ? 20.462 -25.841 6.024   1.00 16.09 ? 103 MET A O   1 
ATOM   791  C CB  . MET A 1 103 ? 19.294 -26.886 3.330   1.00 16.13 ? 103 MET A CB  1 
ATOM   792  C CG  . MET A 1 103 ? 19.235 -26.444 1.890   1.00 23.02 ? 103 MET A CG  1 
ATOM   793  S SD  . MET A 1 103 ? 17.610 -26.657 1.161   1.00 39.66 ? 103 MET A SD  1 
ATOM   794  C CE  . MET A 1 103 ? 17.703 -28.426 0.860   1.00 26.37 ? 103 MET A CE  1 
ATOM   795  N N   . VAL A 1 104 ? 18.483 -26.786 6.550   1.00 14.83 ? 104 VAL A N   1 
ATOM   796  C CA  . VAL A 1 104 ? 18.914 -27.271 7.862   1.00 19.11 ? 104 VAL A CA  1 
ATOM   797  C C   . VAL A 1 104 ? 18.705 -28.779 7.908   1.00 18.75 ? 104 VAL A C   1 
ATOM   798  O O   . VAL A 1 104 ? 17.566 -29.257 7.816   1.00 18.34 ? 104 VAL A O   1 
ATOM   799  C CB  . VAL A 1 104 ? 18.169 -26.573 9.007   1.00 16.59 ? 104 VAL A CB  1 
ATOM   800  C CG1 . VAL A 1 104 ? 18.705 -27.061 10.345  1.00 20.53 ? 104 VAL A CG1 1 
ATOM   801  C CG2 . VAL A 1 104 ? 18.348 -25.069 8.898   1.00 16.18 ? 104 VAL A CG2 1 
ATOM   802  N N   . ASN A 1 105 ? 19.804 -29.524 8.041   1.00 18.73 ? 105 ASN A N   1 
ATOM   803  C CA  . ASN A 1 105 ? 19.759 -30.985 8.017   1.00 19.26 ? 105 ASN A CA  1 
ATOM   804  C C   . ASN A 1 105 ? 19.000 -31.505 6.797   1.00 20.86 ? 105 ASN A C   1 
ATOM   805  O O   . ASN A 1 105 ? 18.220 -32.451 6.885   1.00 23.86 ? 105 ASN A O   1 
ATOM   806  C CB  . ASN A 1 105 ? 19.146 -31.520 9.314   1.00 21.16 ? 105 ASN A CB  1 
ATOM   807  C CG  . ASN A 1 105 ? 19.905 -31.048 10.543  1.00 22.31 ? 105 ASN A CG  1 
ATOM   808  O OD1 . ASN A 1 105 ? 21.132 -30.955 10.519  1.00 20.47 ? 105 ASN A OD1 1 
ATOM   809  N ND2 . ASN A 1 105 ? 19.180 -30.717 11.603  1.00 18.78 ? 105 ASN A ND2 1 
ATOM   810  N N   . GLY A 1 106 ? 19.224 -30.876 5.644   1.00 21.64 ? 106 GLY A N   1 
ATOM   811  C CA  . GLY A 1 106 ? 18.630 -31.323 4.398   1.00 21.57 ? 106 GLY A CA  1 
ATOM   812  C C   . GLY A 1 106 ? 17.256 -30.764 4.072   1.00 23.57 ? 106 GLY A C   1 
ATOM   813  O O   . GLY A 1 106 ? 16.738 -31.042 2.984   1.00 23.04 ? 106 GLY A O   1 
ATOM   814  N N   . GLN A 1 107 ? 16.652 -29.991 4.969   1.00 21.62 ? 107 GLN A N   1 
ATOM   815  C CA  . GLN A 1 107 ? 15.288 -29.494 4.836   1.00 21.42 ? 107 GLN A CA  1 
ATOM   816  C C   . GLN A 1 107 ? 15.336 -28.005 4.521   1.00 19.66 ? 107 GLN A C   1 
ATOM   817  O O   . GLN A 1 107 ? 15.970 -27.249 5.257   1.00 15.12 ? 107 GLN A O   1 
ATOM   818  C CB  . GLN A 1 107 ? 14.536 -29.741 6.148   1.00 24.17 ? 107 GLN A CB  1 
ATOM   819  C CG  . GLN A 1 107 ? 13.408 -28.784 6.480   1.00 26.55 ? 107 GLN A CG  1 
ATOM   820  C CD  . GLN A 1 107 ? 12.684 -29.183 7.762   1.00 35.15 ? 107 GLN A CD  1 
ATOM   821  O OE1 . GLN A 1 107 ? 12.862 -30.292 8.268   1.00 33.12 ? 107 GLN A OE1 1 
ATOM   822  N NE2 . GLN A 1 107 ? 11.897 -28.262 8.313   1.00 36.78 ? 107 GLN A NE2 1 
ATOM   823  N N   . SER A 1 108 ? 14.680 -27.580 3.434   1.00 15.31 ? 108 SER A N   1 
ATOM   824  C CA  . SER A 1 108 ? 14.588 -26.145 3.145   1.00 14.80 ? 108 SER A CA  1 
ATOM   825  C C   . SER A 1 108 ? 13.890 -25.428 4.296   1.00 18.95 ? 108 SER A C   1 
ATOM   826  O O   . SER A 1 108 ? 12.803 -25.827 4.731   1.00 16.80 ? 108 SER A O   1 
ATOM   827  C CB  . SER A 1 108 ? 13.841 -25.894 1.829   1.00 19.30 ? 108 SER A CB  1 
ATOM   828  O OG  . SER A 1 108 ? 13.742 -24.503 1.567   1.00 17.54 ? 108 SER A OG  1 
ATOM   829  N N   . SER A 1 109 ? 14.522 -24.378 4.814   1.00 14.29 ? 109 SER A N   1 
ATOM   830  C CA  . SER A 1 109 ? 14.021 -23.807 6.059   1.00 13.45 ? 109 SER A CA  1 
ATOM   831  C C   . SER A 1 109 ? 13.856 -22.297 6.047   1.00 15.11 ? 109 SER A C   1 
ATOM   832  O O   . SER A 1 109 ? 13.028 -21.771 6.797   1.00 14.18 ? 109 SER A O   1 
ATOM   833  C CB  . SER A 1 109 ? 14.938 -24.195 7.222   1.00 14.37 ? 109 SER A CB  1 
ATOM   834  O OG  . SER A 1 109 ? 14.972 -25.599 7.385   1.00 17.78 ? 109 SER A OG  1 
ATOM   835  N N   . TYR A 1 110 ? 14.684 -21.586 5.277   1.00 12.49 ? 110 TYR A N   1 
ATOM   836  C CA  . TYR A 1 110 ? 14.606 -20.135 5.182   1.00 13.82 ? 110 TYR A CA  1 
ATOM   837  C C   . TYR A 1 110 ? 15.059 -19.730 3.785   1.00 12.74 ? 110 TYR A C   1 
ATOM   838  O O   . TYR A 1 110 ? 15.848 -20.438 3.154   1.00 12.35 ? 110 TYR A O   1 
ATOM   839  C CB  . TYR A 1 110 ? 15.497 -19.427 6.232   1.00 13.45 ? 110 TYR A CB  1 
ATOM   840  C CG  . TYR A 1 110 ? 15.417 -20.029 7.629   1.00 13.58 ? 110 TYR A CG  1 
ATOM   841  C CD1 . TYR A 1 110 ? 16.236 -21.090 7.992   1.00 12.12 ? 110 TYR A CD1 1 
ATOM   842  C CD2 . TYR A 1 110 ? 14.494 -19.565 8.560   1.00 12.85 ? 110 TYR A CD2 1 
ATOM   843  C CE1 . TYR A 1 110 ? 16.157 -21.655 9.259   1.00 14.61 ? 110 TYR A CE1 1 
ATOM   844  C CE2 . TYR A 1 110 ? 14.410 -20.116 9.827   1.00 12.45 ? 110 TYR A CE2 1 
ATOM   845  C CZ  . TYR A 1 110 ? 15.236 -21.163 10.165  1.00 13.63 ? 110 TYR A CZ  1 
ATOM   846  O OH  . TYR A 1 110 ? 15.150 -21.729 11.404  1.00 13.09 ? 110 TYR A OH  1 
ATOM   847  N N   . THR A 1 111 ? 14.555 -18.589 3.299   1.00 13.92 ? 111 THR A N   1 
ATOM   848  C CA  . THR A 1 111 ? 15.149 -17.935 2.134   1.00 12.68 ? 111 THR A CA  1 
ATOM   849  C C   . THR A 1 111 ? 15.184 -16.429 2.373   1.00 14.47 ? 111 THR A C   1 
ATOM   850  O O   . THR A 1 111 ? 14.477 -15.898 3.230   1.00 14.91 ? 111 THR A O   1 
ATOM   851  C CB  . THR A 1 111 ? 14.409 -18.228 0.805   1.00 16.97 ? 111 THR A CB  1 
ATOM   852  O OG1 . THR A 1 111 ? 13.117 -17.612 0.809   1.00 17.59 ? 111 THR A OG1 1 
ATOM   853  C CG2 . THR A 1 111 ? 14.245 -19.732 0.560   1.00 15.61 ? 111 THR A CG2 1 
ATOM   854  N N   . PHE A 1 112 ? 16.016 -15.744 1.591   1.00 11.39 ? 112 PHE A N   1 
ATOM   855  C CA  . PHE A 1 112 ? 16.289 -14.323 1.792   1.00 12.77 ? 112 PHE A CA  1 
ATOM   856  C C   . PHE A 1 112 ? 16.661 -13.756 0.426   1.00 12.01 ? 112 PHE A C   1 
ATOM   857  O O   . PHE A 1 112 ? 17.707 -14.115 -0.121  1.00 12.46 ? 112 PHE A O   1 
ATOM   858  C CB  . PHE A 1 112 ? 17.417 -14.138 2.814   1.00 11.64 ? 112 PHE A CB  1 
ATOM   859  C CG  . PHE A 1 112 ? 17.712 -12.707 3.177   1.00 11.65 ? 112 PHE A CG  1 
ATOM   860  C CD1 . PHE A 1 112 ? 17.024 -12.077 4.200   1.00 12.93 ? 112 PHE A CD1 1 
ATOM   861  C CD2 . PHE A 1 112 ? 18.721 -12.002 2.527   1.00 11.93 ? 112 PHE A CD2 1 
ATOM   862  C CE1 . PHE A 1 112 ? 17.318 -10.765 4.551   1.00 13.73 ? 112 PHE A CE1 1 
ATOM   863  C CE2 . PHE A 1 112 ? 19.019 -10.690 2.879   1.00 12.58 ? 112 PHE A CE2 1 
ATOM   864  C CZ  . PHE A 1 112 ? 18.321 -10.071 3.887   1.00 12.28 ? 112 PHE A CZ  1 
ATOM   865  N N   . ASP A 1 113 ? 15.806 -12.907 -0.140  1.00 11.90 ? 113 ASP A N   1 
ATOM   866  C CA  . ASP A 1 113 ? 16.079 -12.384 -1.475  1.00 12.21 ? 113 ASP A CA  1 
ATOM   867  C C   . ASP A 1 113 ? 17.296 -11.460 -1.453  1.00 12.66 ? 113 ASP A C   1 
ATOM   868  O O   . ASP A 1 113 ? 17.500 -10.699 -0.508  1.00 12.27 ? 113 ASP A O   1 
ATOM   869  C CB  . ASP A 1 113 ? 14.878 -11.616 -2.023  1.00 15.85 ? 113 ASP A CB  1 
ATOM   870  C CG  . ASP A 1 113 ? 13.708 -12.525 -2.400  1.00 18.50 ? 113 ASP A CG  1 
ATOM   871  O OD1 . ASP A 1 113 ? 13.778 -13.745 -2.192  1.00 16.59 ? 113 ASP A OD1 1 
ATOM   872  O OD2 . ASP A 1 113 ? 12.733 -12.021 -2.973  1.00 23.68 ? 113 ASP A OD2 1 
ATOM   873  N N   . HIS A 1 114 ? 18.083 -11.499 -2.525  1.00 13.25 ? 114 HIS A N   1 
ATOM   874  C CA  . HIS A 1 114 ? 19.277 -10.670 -2.591  1.00 15.62 ? 114 HIS A CA  1 
ATOM   875  C C   . HIS A 1 114 ? 18.922 -9.195  -2.516  1.00 19.62 ? 114 HIS A C   1 
ATOM   876  O O   . HIS A 1 114 ? 18.094 -8.703  -3.289  1.00 17.44 ? 114 HIS A O   1 
ATOM   877  C CB  . HIS A 1 114 ? 20.050 -10.956 -3.875  1.00 15.24 ? 114 HIS A CB  1 
ATOM   878  C CG  . HIS A 1 114 ? 20.549 -12.360 -3.970  1.00 16.26 ? 114 HIS A CG  1 
ATOM   879  N ND1 . HIS A 1 114 ? 21.340 -12.930 -2.996  1.00 13.89 ? 114 HIS A ND1 1 
ATOM   880  C CD2 . HIS A 1 114 ? 20.370 -13.311 -4.917  1.00 14.97 ? 114 HIS A CD2 1 
ATOM   881  C CE1 . HIS A 1 114 ? 21.614 -14.177 -3.331  1.00 13.88 ? 114 HIS A CE1 1 
ATOM   882  N NE2 . HIS A 1 114 ? 21.050 -14.430 -4.499  1.00 14.33 ? 114 HIS A NE2 1 
ATOM   883  N N   . ARG A 1 115 ? 19.556 -8.491  -1.577  1.00 14.08 ? 115 ARG A N   1 
ATOM   884  C CA  . ARG A 1 115 ? 19.494 -7.035  -1.520  1.00 16.06 ? 115 ARG A CA  1 
ATOM   885  C C   . ARG A 1 115 ? 20.726 -6.372  -2.116  1.00 21.48 ? 115 ARG A C   1 
ATOM   886  O O   . ARG A 1 115 ? 20.618 -5.288  -2.696  1.00 16.97 ? 115 ARG A O   1 
ATOM   887  C CB  . ARG A 1 115 ? 19.318 -6.569  -0.072  1.00 15.74 ? 115 ARG A CB  1 
ATOM   888  C CG  . ARG A 1 115 ? 18.185 -7.277  0.634   1.00 16.80 ? 115 ARG A CG  1 
ATOM   889  C CD  . ARG A 1 115 ? 18.130 -6.891  2.082   1.00 17.96 ? 115 ARG A CD  1 
ATOM   890  N NE  . ARG A 1 115 ? 16.912 -7.373  2.716   1.00 15.94 ? 115 ARG A NE  1 
ATOM   891  C CZ  . ARG A 1 115 ? 16.604 -7.148  3.990   1.00 17.23 ? 115 ARG A CZ  1 
ATOM   892  N NH1 . ARG A 1 115 ? 17.423 -6.442  4.755   1.00 16.62 ? 115 ARG A NH1 1 
ATOM   893  N NH2 . ARG A 1 115 ? 15.484 -7.630  4.499   1.00 15.94 ? 115 ARG A NH2 1 
ATOM   894  N N   . ILE A 1 116 ? 21.880 -7.016  -1.982  1.00 17.13 ? 116 ILE A N   1 
ATOM   895  C CA  . ILE A 1 116 ? 23.135 -6.640  -2.611  1.00 17.76 ? 116 ILE A CA  1 
ATOM   896  C C   . ILE A 1 116 ? 23.580 -7.850  -3.414  1.00 18.08 ? 116 ILE A C   1 
ATOM   897  O O   . ILE A 1 116 ? 23.319 -8.994  -3.012  1.00 18.84 ? 116 ILE A O   1 
ATOM   898  C CB  . ILE A 1 116 ? 24.178 -6.255  -1.539  1.00 14.46 ? 116 ILE A CB  1 
ATOM   899  C CG1 . ILE A 1 116 ? 23.707 -5.034  -0.731  1.00 18.74 ? 116 ILE A CG1 1 
ATOM   900  C CG2 . ILE A 1 116 ? 25.557 -6.031  -2.142  1.00 16.05 ? 116 ILE A CG2 1 
ATOM   901  C CD1 . ILE A 1 116 ? 24.446 -4.881  0.604   1.00 21.40 ? 116 ILE A CD1 1 
ATOM   902  N N   . LYS A 1 117 ? 24.209 -7.608  -4.561  1.00 16.54 ? 117 LYS A N   1 
ATOM   903  C CA  . LYS A 1 117 ? 24.630 -8.731  -5.381  1.00 18.03 ? 117 LYS A CA  1 
ATOM   904  C C   . LYS A 1 117 ? 25.587 -9.605  -4.585  1.00 16.05 ? 117 LYS A C   1 
ATOM   905  O O   . LYS A 1 117 ? 26.435 -9.089  -3.839  1.00 15.05 ? 117 LYS A O   1 
ATOM   906  C CB  . LYS A 1 117 ? 25.302 -8.268  -6.677  1.00 22.48 ? 117 LYS A CB  1 
ATOM   907  C CG  . LYS A 1 117 ? 26.628 -7.543  -6.480  1.00 20.78 ? 117 LYS A CG  1 
ATOM   908  C CD  . LYS A 1 117 ? 27.160 -7.103  -7.833  1.00 30.29 ? 117 LYS A CD  1 
ATOM   909  C CE  . LYS A 1 117 ? 28.502 -6.387  -7.746  1.00 33.22 ? 117 LYS A CE  1 
ATOM   910  N NZ  . LYS A 1 117 ? 28.977 -5.991  -9.107  1.00 40.25 ? 117 LYS A NZ  1 
ATOM   911  N N   . PRO A 1 118 ? 25.455 -10.926 -4.661  1.00 15.15 ? 118 PRO A N   1 
ATOM   912  C CA  . PRO A 1 118 ? 26.354 -11.799 -3.892  1.00 14.52 ? 118 PRO A CA  1 
ATOM   913  C C   . PRO A 1 118 ? 27.812 -11.642 -4.286  1.00 19.35 ? 118 PRO A C   1 
ATOM   914  O O   . PRO A 1 118 ? 28.695 -11.961 -3.475  1.00 14.79 ? 118 PRO A O   1 
ATOM   915  C CB  . PRO A 1 118 ? 25.839 -13.210 -4.197  1.00 17.00 ? 118 PRO A CB  1 
ATOM   916  C CG  . PRO A 1 118 ? 25.000 -13.050 -5.461  1.00 17.80 ? 118 PRO A CG  1 
ATOM   917  C CD  . PRO A 1 118 ? 24.445 -11.671 -5.429  1.00 16.81 ? 118 PRO A CD  1 
ATOM   918  N N   . GLU A 1 119 ? 28.095 -11.152 -5.501  1.00 17.41 ? 119 GLU A N   1 
ATOM   919  C CA  . GLU A 1 119 ? 29.475 -10.922 -5.924  1.00 16.28 ? 119 GLU A CA  1 
ATOM   920  C C   . GLU A 1 119 ? 30.183 -9.879  -5.073  1.00 17.43 ? 119 GLU A C   1 
ATOM   921  O O   . GLU A 1 119 ? 31.412 -9.740  -5.172  1.00 16.98 ? 119 GLU A O   1 
ATOM   922  C CB  . GLU A 1 119 ? 29.515 -10.487 -7.398  1.00 18.95 ? 119 GLU A CB  1 
ATOM   923  C CG  . GLU A 1 119 ? 29.250 -11.613 -8.361  1.00 19.44 ? 119 GLU A CG  1 
ATOM   924  C CD  . GLU A 1 119 ? 27.776 -11.897 -8.554  1.00 23.98 ? 119 GLU A CD  1 
ATOM   925  O OE1 . GLU A 1 119 ? 27.455 -12.902 -9.228  1.00 32.38 ? 119 GLU A OE1 1 
ATOM   926  O OE2 . GLU A 1 119 ? 26.933 -11.141 -8.020  1.00 20.26 ? 119 GLU A OE2 1 
ATOM   927  N N   . ALA A 1 120 ? 29.443 -9.131  -4.262  1.00 13.15 ? 120 ALA A N   1 
ATOM   928  C CA  . ALA A 1 120 ? 30.049 -8.178  -3.341  1.00 15.54 ? 120 ALA A CA  1 
ATOM   929  C C   . ALA A 1 120 ? 30.663 -8.845  -2.112  1.00 16.23 ? 120 ALA A C   1 
ATOM   930  O O   . ALA A 1 120 ? 31.429 -8.196  -1.390  1.00 14.62 ? 120 ALA A O   1 
ATOM   931  C CB  . ALA A 1 120 ? 29.010 -7.151  -2.897  1.00 13.67 ? 120 ALA A CB  1 
ATOM   932  N N   . VAL A 1 121 ? 30.367 -10.119 -1.865  1.00 13.60 ? 121 VAL A N   1 
ATOM   933  C CA  . VAL A 1 121 ? 30.874 -10.780 -0.665  1.00 13.67 ? 121 VAL A CA  1 
ATOM   934  C C   . VAL A 1 121 ? 32.367 -11.051 -0.811  1.00 14.29 ? 121 VAL A C   1 
ATOM   935  O O   . VAL A 1 121 ? 32.825 -11.546 -1.847  1.00 12.71 ? 121 VAL A O   1 
ATOM   936  C CB  . VAL A 1 121 ? 30.098 -12.077 -0.404  1.00 12.79 ? 121 VAL A CB  1 
ATOM   937  C CG1 . VAL A 1 121 ? 30.772 -12.884 0.703   1.00 9.93  ? 121 VAL A CG1 1 
ATOM   938  C CG2 . VAL A 1 121 ? 28.640 -11.743 -0.028  1.00 10.65 ? 121 VAL A CG2 1 
ATOM   939  N N   . LYS A 1 122 ? 33.134 -10.732 0.240   1.00 11.20 ? 122 LYS A N   1 
ATOM   940  C CA  . LYS A 1 122 ? 34.554 -11.062 0.289   1.00 12.23 ? 122 LYS A CA  1 
ATOM   941  C C   . LYS A 1 122 ? 34.941 -11.919 1.482   1.00 13.75 ? 122 LYS A C   1 
ATOM   942  O O   . LYS A 1 122 ? 36.095 -12.367 1.543   1.00 13.60 ? 122 LYS A O   1 
ATOM   943  C CB  . LYS A 1 122 ? 35.416 -9.784  0.317   1.00 15.01 ? 122 LYS A CB  1 
ATOM   944  C CG  . LYS A 1 122 ? 35.317 -8.913  -0.944  1.00 19.62 ? 122 LYS A CG  1 
ATOM   945  C CD  . LYS A 1 122 ? 36.396 -7.812  -0.898  1.00 21.10 ? 122 LYS A CD  1 
ATOM   946  C CE  . LYS A 1 122 ? 36.446 -6.999  -2.163  1.00 29.17 ? 122 LYS A CE  1 
ATOM   947  N NZ  . LYS A 1 122 ? 35.162 -6.280  -2.325  1.00 30.76 ? 122 LYS A NZ  1 
ATOM   948  N N   . MET A 1 123 ? 34.034 -12.148 2.436   1.00 11.48 ? 123 MET A N   1 
ATOM   949  C CA  . MET A 1 123 ? 34.384 -12.856 3.659   1.00 11.31 ? 123 MET A CA  1 
ATOM   950  C C   . MET A 1 123 ? 33.118 -13.420 4.294   1.00 11.52 ? 123 MET A C   1 
ATOM   951  O O   . MET A 1 123 ? 32.037 -12.845 4.156   1.00 11.34 ? 123 MET A O   1 
ATOM   952  C CB  . MET A 1 123 ? 35.095 -11.921 4.649   1.00 12.96 ? 123 MET A CB  1 
ATOM   953  C CG  . MET A 1 123 ? 35.416 -12.585 5.980   1.00 16.32 ? 123 MET A CG  1 
ATOM   954  S SD  . MET A 1 123 ? 34.142 -12.169 7.200   1.00 20.02 ? 123 MET A SD  1 
ATOM   955  C CE  . MET A 1 123 ? 34.753 -10.574 7.779   1.00 18.17 ? 123 MET A CE  1 
ATOM   956  N N   . VAL A 1 124 ? 33.263 -14.557 4.978   1.00 10.06 ? 124 VAL A N   1 
ATOM   957  C CA  . VAL A 1 124 ? 32.190 -15.181 5.751   1.00 10.16 ? 124 VAL A CA  1 
ATOM   958  C C   . VAL A 1 124 ? 32.668 -15.339 7.186   1.00 12.63 ? 124 VAL A C   1 
ATOM   959  O O   . VAL A 1 124 ? 33.789 -15.800 7.419   1.00 11.59 ? 124 VAL A O   1 
ATOM   960  C CB  . VAL A 1 124 ? 31.797 -16.552 5.175   1.00 9.71  ? 124 VAL A CB  1 
ATOM   961  C CG1 . VAL A 1 124 ? 30.751 -17.216 6.053   1.00 9.09  ? 124 VAL A CG1 1 
ATOM   962  C CG2 . VAL A 1 124 ? 31.284 -16.386 3.741   1.00 12.77 ? 124 VAL A CG2 1 
ATOM   963  N N   . GLN A 1 125 ? 31.821 -14.981 8.147   1.00 11.07 ? 125 GLN A N   1 
ATOM   964  C CA  . GLN A 1 125 ? 32.144 -15.186 9.553   1.00 12.16 ? 125 GLN A CA  1 
ATOM   965  C C   . GLN A 1 125 ? 31.047 -16.021 10.201  1.00 10.49 ? 125 GLN A C   1 
ATOM   966  O O   . GLN A 1 125 ? 29.862 -15.762 9.974   1.00 13.08 ? 125 GLN A O   1 
ATOM   967  C CB  . GLN A 1 125 ? 32.289 -13.846 10.284  1.00 12.31 ? 125 GLN A CB  1 
ATOM   968  C CG  . GLN A 1 125 ? 32.845 -14.013 11.689  1.00 17.05 ? 125 GLN A CG  1 
ATOM   969  C CD  . GLN A 1 125 ? 33.194 -12.690 12.338  1.00 27.33 ? 125 GLN A CD  1 
ATOM   970  O OE1 . GLN A 1 125 ? 32.360 -11.780 12.430  1.00 24.42 ? 125 GLN A OE1 1 
ATOM   971  N NE2 . GLN A 1 125 ? 34.458 -12.548 12.730  1.00 34.22 ? 125 GLN A NE2 1 
ATOM   972  N N   . VAL A 1 126 ? 31.437 -17.019 10.996  1.00 9.62  ? 126 VAL A N   1 
ATOM   973  C CA  . VAL A 1 126 ? 30.510 -17.844 11.772  1.00 10.61 ? 126 VAL A CA  1 
ATOM   974  C C   . VAL A 1 126 ? 30.894 -17.717 13.240  1.00 12.72 ? 126 VAL A C   1 
ATOM   975  O O   . VAL A 1 126 ? 32.045 -17.995 13.603  1.00 12.44 ? 126 VAL A O   1 
ATOM   976  C CB  . VAL A 1 126 ? 30.547 -19.323 11.345  1.00 12.46 ? 126 VAL A CB  1 
ATOM   977  C CG1 . VAL A 1 126 ? 29.482 -20.105 12.083  1.00 10.25 ? 126 VAL A CG1 1 
ATOM   978  C CG2 . VAL A 1 126 ? 30.364 -19.468 9.824   1.00 10.02 ? 126 VAL A CG2 1 
ATOM   979  N N   . TRP A 1 127 ? 29.944 -17.315 14.084  1.00 10.73 ? 127 TRP A N   1 
ATOM   980  C CA  . TRP A 1 127 ? 30.322 -17.065 15.473  1.00 10.69 ? 127 TRP A CA  1 
ATOM   981  C C   . TRP A 1 127 ? 29.104 -17.217 16.382  1.00 12.18 ? 127 TRP A C   1 
ATOM   982  O O   . TRP A 1 127 ? 28.030 -17.650 15.947  1.00 11.05 ? 127 TRP A O   1 
ATOM   983  C CB  . TRP A 1 127 ? 30.997 -15.692 15.605  1.00 10.66 ? 127 TRP A CB  1 
ATOM   984  C CG  . TRP A 1 127 ? 30.173 -14.467 15.219  1.00 10.06 ? 127 TRP A CG  1 
ATOM   985  C CD1 . TRP A 1 127 ? 29.591 -14.183 13.997  1.00 12.12 ? 127 TRP A CD1 1 
ATOM   986  C CD2 . TRP A 1 127 ? 29.855 -13.370 16.074  1.00 11.86 ? 127 TRP A CD2 1 
ATOM   987  N NE1 . TRP A 1 127 ? 28.936 -12.965 14.060  1.00 10.25 ? 127 TRP A NE1 1 
ATOM   988  C CE2 . TRP A 1 127 ? 29.091 -12.448 15.321  1.00 13.33 ? 127 TRP A CE2 1 
ATOM   989  C CE3 . TRP A 1 127 ? 30.151 -13.071 17.412  1.00 14.52 ? 127 TRP A CE3 1 
ATOM   990  C CZ2 . TRP A 1 127 ? 28.608 -11.257 15.867  1.00 13.43 ? 127 TRP A CZ2 1 
ATOM   991  C CZ3 . TRP A 1 127 ? 29.671 -11.890 17.953  1.00 13.19 ? 127 TRP A CZ3 1 
ATOM   992  C CH2 . TRP A 1 127 ? 28.907 -10.998 17.182  1.00 14.86 ? 127 TRP A CH2 1 
ATOM   993  N N   . ARG A 1 128 ? 29.297 -16.848 17.654  1.00 11.31 ? 128 ARG A N   1 
ATOM   994  C CA  . ARG A 1 128 ? 28.403 -17.038 18.796  1.00 11.16 ? 128 ARG A CA  1 
ATOM   995  C C   . ARG A 1 128 ? 28.520 -18.466 19.334  1.00 12.85 ? 128 ARG A C   1 
ATOM   996  O O   . ARG A 1 128 ? 29.610 -19.052 19.288  1.00 12.92 ? 128 ARG A O   1 
ATOM   997  C CB  . ARG A 1 128 ? 26.968 -16.613 18.448  1.00 11.22 ? 128 ARG A CB  1 
ATOM   998  C CG  . ARG A 1 128 ? 26.980 -15.143 17.960  1.00 13.06 ? 128 ARG A CG  1 
ATOM   999  C CD  . ARG A 1 128 ? 25.853 -14.314 18.486  1.00 16.01 ? 128 ARG A CD  1 
ATOM   1000 N NE  . ARG A 1 128 ? 25.680 -13.011 17.822  1.00 13.48 ? 128 ARG A NE  1 
ATOM   1001 C CZ  . ARG A 1 128 ? 25.875 -11.831 18.416  1.00 13.69 ? 128 ARG A CZ  1 
ATOM   1002 N NH1 . ARG A 1 128 ? 26.293 -11.766 19.681  1.00 12.99 ? 128 ARG A NH1 1 
ATOM   1003 N NH2 . ARG A 1 128 ? 25.639 -10.702 17.751  1.00 11.89 ? 128 ARG A NH2 1 
ATOM   1004 N N   . ASP A 1 129 ? 27.435 -19.019 19.876  1.00 10.82 ? 129 ASP A N   1 
ATOM   1005 C CA  . ASP A 1 129 ? 27.501 -20.125 20.841  1.00 12.57 ? 129 ASP A CA  1 
ATOM   1006 C C   . ASP A 1 129 ? 27.480 -21.506 20.186  1.00 13.38 ? 129 ASP A C   1 
ATOM   1007 O O   . ASP A 1 129 ? 26.642 -22.353 20.499  1.00 13.00 ? 129 ASP A O   1 
ATOM   1008 C CB  . ASP A 1 129 ? 26.352 -19.968 21.829  1.00 10.71 ? 129 ASP A CB  1 
ATOM   1009 C CG  . ASP A 1 129 ? 26.333 -18.587 22.463  1.00 14.69 ? 129 ASP A CG  1 
ATOM   1010 O OD1 . ASP A 1 129 ? 27.378 -18.191 23.043  1.00 14.68 ? 129 ASP A OD1 1 
ATOM   1011 O OD2 . ASP A 1 129 ? 25.325 -17.864 22.307  1.00 14.24 ? 129 ASP A OD2 1 
ATOM   1012 N N   . ILE A 1 130 ? 28.414 -21.754 19.273  1.00 12.27 ? 130 ILE A N   1 
ATOM   1013 C CA  . ILE A 1 130 ? 28.510 -23.047 18.614  1.00 14.04 ? 130 ILE A CA  1 
ATOM   1014 C C   . ILE A 1 130 ? 29.963 -23.495 18.601  1.00 16.02 ? 130 ILE A C   1 
ATOM   1015 O O   . ILE A 1 130 ? 30.895 -22.694 18.703  1.00 13.88 ? 130 ILE A O   1 
ATOM   1016 C CB  . ILE A 1 130 ? 27.979 -23.031 17.165  1.00 13.11 ? 130 ILE A CB  1 
ATOM   1017 C CG1 . ILE A 1 130 ? 28.841 -22.081 16.336  1.00 14.88 ? 130 ILE A CG1 1 
ATOM   1018 C CG2 . ILE A 1 130 ? 26.493 -22.633 17.126  1.00 12.72 ? 130 ILE A CG2 1 
ATOM   1019 C CD1 . ILE A 1 130 ? 28.859 -22.407 14.884  1.00 24.06 ? 130 ILE A CD1 1 
ATOM   1020 N N   . SER A 1 131 ? 30.138 -24.798 18.473  1.00 13.42 ? 131 SER A N   1 
ATOM   1021 C CA  . SER A 1 131 ? 31.389 -25.365 18.007  1.00 19.14 ? 131 SER A CA  1 
ATOM   1022 C C   . SER A 1 131 ? 31.198 -25.767 16.555  1.00 17.98 ? 131 SER A C   1 
ATOM   1023 O O   . SER A 1 131 ? 30.074 -25.940 16.083  1.00 15.47 ? 131 SER A O   1 
ATOM   1024 C CB  . SER A 1 131 ? 31.800 -26.571 18.858  1.00 20.94 ? 131 SER A CB  1 
ATOM   1025 O OG  . SER A 1 131 ? 30.771 -27.535 18.867  1.00 17.94 ? 131 SER A OG  1 
ATOM   1026 N N   . LEU A 1 132 ? 32.308 -25.906 15.843  1.00 15.33 ? 132 LEU A N   1 
ATOM   1027 C CA  . LEU A 1 132 ? 32.276 -26.070 14.402  1.00 18.25 ? 132 LEU A CA  1 
ATOM   1028 C C   . LEU A 1 132 ? 33.200 -27.225 14.027  1.00 20.29 ? 132 LEU A C   1 
ATOM   1029 O O   . LEU A 1 132 ? 34.351 -27.256 14.470  1.00 19.78 ? 132 LEU A O   1 
ATOM   1030 C CB  . LEU A 1 132 ? 32.716 -24.742 13.790  1.00 20.00 ? 132 LEU A CB  1 
ATOM   1031 C CG  . LEU A 1 132 ? 32.200 -24.248 12.467  1.00 29.30 ? 132 LEU A CG  1 
ATOM   1032 C CD1 . LEU A 1 132 ? 30.694 -24.259 12.598  1.00 22.68 ? 132 LEU A CD1 1 
ATOM   1033 C CD2 . LEU A 1 132 ? 32.719 -22.823 12.285  1.00 20.71 ? 132 LEU A CD2 1 
ATOM   1034 N N   . THR A 1 133 ? 32.696 -28.194 13.252  1.00 19.12 ? 133 THR A N   1 
ATOM   1035 C CA  . THR A 1 133 ? 33.562 -29.236 12.702  1.00 21.09 ? 133 THR A CA  1 
ATOM   1036 C C   . THR A 1 133 ? 33.781 -29.145 11.195  1.00 23.60 ? 133 THR A C   1 
ATOM   1037 O O   . THR A 1 133 ? 34.715 -29.776 10.690  1.00 20.67 ? 133 THR A O   1 
ATOM   1038 C CB  . THR A 1 133 ? 33.015 -30.637 13.014  1.00 22.17 ? 133 THR A CB  1 
ATOM   1039 O OG1 . THR A 1 133 ? 31.660 -30.736 12.571  1.00 23.67 ? 133 THR A OG1 1 
ATOM   1040 C CG2 . THR A 1 133 ? 33.072 -30.911 14.520  1.00 22.96 ? 133 THR A CG2 1 
ATOM   1041 N N   . LYS A 1 134 ? 32.961 -28.399 10.459  1.00 18.21 ? 134 LYS A N   1 
ATOM   1042 C CA  . LYS A 1 134 ? 33.164 -28.323 9.020   1.00 17.33 ? 134 LYS A CA  1 
ATOM   1043 C C   . LYS A 1 134 ? 32.694 -26.982 8.485   1.00 17.72 ? 134 LYS A C   1 
ATOM   1044 O O   . LYS A 1 134 ? 31.626 -26.498 8.871   1.00 14.32 ? 134 LYS A O   1 
ATOM   1045 C CB  . LYS A 1 134 ? 32.432 -29.442 8.265   1.00 19.90 ? 134 LYS A CB  1 
ATOM   1046 C CG  . LYS A 1 134 ? 32.734 -29.369 6.765   1.00 28.06 ? 134 LYS A CG  1 
ATOM   1047 C CD  . LYS A 1 134 ? 32.694 -30.707 6.041   1.00 36.70 ? 134 LYS A CD  1 
ATOM   1048 C CE  . LYS A 1 134 ? 32.377 -30.504 4.550   1.00 40.69 ? 134 LYS A CE  1 
ATOM   1049 N NZ  . LYS A 1 134 ? 31.391 -31.504 4.042   1.00 49.79 ? 134 LYS A NZ  1 
ATOM   1050 N N   . PHE A 1 135 ? 33.501 -26.391 7.599   1.00 14.16 ? 135 PHE A N   1 
ATOM   1051 C CA  . PHE A 1 135 ? 33.117 -25.198 6.850   1.00 13.92 ? 135 PHE A CA  1 
ATOM   1052 C C   . PHE A 1 135 ? 33.634 -25.344 5.426   1.00 16.06 ? 135 PHE A C   1 
ATOM   1053 O O   . PHE A 1 135 ? 34.810 -25.659 5.223   1.00 15.59 ? 135 PHE A O   1 
ATOM   1054 C CB  . PHE A 1 135 ? 33.676 -23.918 7.499   1.00 13.49 ? 135 PHE A CB  1 
ATOM   1055 C CG  . PHE A 1 135 ? 33.271 -22.649 6.788   1.00 15.48 ? 135 PHE A CG  1 
ATOM   1056 C CD1 . PHE A 1 135 ? 33.955 -22.208 5.661   1.00 13.51 ? 135 PHE A CD1 1 
ATOM   1057 C CD2 . PHE A 1 135 ? 32.165 -21.923 7.225   1.00 14.04 ? 135 PHE A CD2 1 
ATOM   1058 C CE1 . PHE A 1 135 ? 33.569 -21.054 4.996   1.00 11.85 ? 135 PHE A CE1 1 
ATOM   1059 C CE2 . PHE A 1 135 ? 31.763 -20.768 6.555   1.00 13.56 ? 135 PHE A CE2 1 
ATOM   1060 C CZ  . PHE A 1 135 ? 32.471 -20.334 5.441   1.00 12.62 ? 135 PHE A CZ  1 
ATOM   1061 N N   . ASN A 1 136 ? 32.767 -25.105 4.444   1.00 14.69 ? 136 ASN A N   1 
ATOM   1062 C CA  . ASN A 1 136 ? 33.172 -25.196 3.048   1.00 14.62 ? 136 ASN A CA  1 
ATOM   1063 C C   . ASN A 1 136 ? 32.387 -24.198 2.210   1.00 17.14 ? 136 ASN A C   1 
ATOM   1064 O O   . ASN A 1 136 ? 31.177 -24.047 2.393   1.00 14.53 ? 136 ASN A O   1 
ATOM   1065 C CB  . ASN A 1 136 ? 32.939 -26.596 2.476   1.00 15.28 ? 136 ASN A CB  1 
ATOM   1066 C CG  . ASN A 1 136 ? 33.303 -26.674 1.000   1.00 20.42 ? 136 ASN A CG  1 
ATOM   1067 O OD1 . ASN A 1 136 ? 32.424 -26.660 0.133   1.00 20.67 ? 136 ASN A OD1 1 
ATOM   1068 N ND2 . ASN A 1 136 ? 34.600 -26.769 0.707   1.00 21.71 ? 136 ASN A ND2 1 
ATOM   1069 N N   . VAL A 1 137 ? 33.070 -23.541 1.271   1.00 13.11 ? 137 VAL A N   1 
ATOM   1070 C CA  . VAL A 1 137 ? 32.419 -22.750 0.234   1.00 14.56 ? 137 VAL A CA  1 
ATOM   1071 C C   . VAL A 1 137 ? 32.707 -23.433 -1.088  1.00 17.33 ? 137 VAL A C   1 
ATOM   1072 O O   . VAL A 1 137 ? 33.871 -23.720 -1.387  1.00 16.96 ? 137 VAL A O   1 
ATOM   1073 C CB  . VAL A 1 137 ? 32.927 -21.298 0.210   1.00 17.96 ? 137 VAL A CB  1 
ATOM   1074 C CG1 . VAL A 1 137 ? 32.373 -20.562 -1.023  1.00 14.40 ? 137 VAL A CG1 1 
ATOM   1075 C CG2 . VAL A 1 137 ? 32.564 -20.576 1.497   1.00 13.33 ? 137 VAL A CG2 1 
ATOM   1076 N N   . SER A 1 138 ? 31.664 -23.717 -1.871  1.00 12.91 ? 138 SER A N   1 
ATOM   1077 C CA  . SER A 1 138 ? 31.898 -24.407 -3.128  1.00 16.79 ? 138 SER A CA  1 
ATOM   1078 C C   . SER A 1 138 ? 32.317 -23.386 -4.178  1.00 24.84 ? 138 SER A C   1 
ATOM   1079 O O   . SER A 1 138 ? 31.889 -22.226 -4.149  1.00 21.27 ? 138 SER A O   1 
ATOM   1080 C CB  . SER A 1 138 ? 30.653 -25.138 -3.636  1.00 21.61 ? 138 SER A CB  1 
ATOM   1081 O OG  . SER A 1 138 ? 29.620 -24.204 -3.914  1.00 20.24 ? 138 SER A OG  1 
ATOM   1082 N N   . TYR A 1 139 ? 33.145 -23.832 -5.123  1.00 21.10 ? 139 TYR A N   1 
ATOM   1083 C CA  . TYR A 1 139 ? 33.693 -22.967 -6.165  1.00 24.01 ? 139 TYR A CA  1 
ATOM   1084 C C   . TYR A 1 139 ? 33.656 -23.672 -7.514  1.00 22.79 ? 139 TYR A C   1 
ATOM   1085 O O   . TYR A 1 139 ? 34.600 -23.568 -8.302  1.00 23.82 ? 139 TYR A O   1 
ATOM   1086 C CB  . TYR A 1 139 ? 35.131 -22.553 -5.836  1.00 18.56 ? 139 TYR A CB  1 
ATOM   1087 C CG  . TYR A 1 139 ? 35.257 -21.551 -4.713  1.00 20.72 ? 139 TYR A CG  1 
ATOM   1088 C CD1 . TYR A 1 139 ? 34.997 -20.199 -4.931  1.00 18.51 ? 139 TYR A CD1 1 
ATOM   1089 C CD2 . TYR A 1 139 ? 35.611 -21.962 -3.423  1.00 18.41 ? 139 TYR A CD2 1 
ATOM   1090 C CE1 . TYR A 1 139 ? 35.115 -19.270 -3.905  1.00 16.62 ? 139 TYR A CE1 1 
ATOM   1091 C CE2 . TYR A 1 139 ? 35.725 -21.041 -2.383  1.00 18.61 ? 139 TYR A CE2 1 
ATOM   1092 C CZ  . TYR A 1 139 ? 35.475 -19.698 -2.633  1.00 19.45 ? 139 TYR A CZ  1 
ATOM   1093 O OH  . TYR A 1 139 ? 35.582 -18.777 -1.615  1.00 18.37 ? 139 TYR A OH  1 
ATOM   1094 N N   . LEU A 1 140 ? 32.571 -24.404 -7.804  1.00 21.36 ? 140 LEU A N   1 
ATOM   1095 C CA  . LEU A 1 140 ? 32.556 -25.292 -8.965  1.00 26.38 ? 140 LEU A CA  1 
ATOM   1096 C C   . LEU A 1 140 ? 31.950 -24.677 -10.222 1.00 27.66 ? 140 LEU A C   1 
ATOM   1097 O O   . LEU A 1 140 ? 32.162 -25.210 -11.321 1.00 19.95 ? 140 LEU A O   1 
ATOM   1098 C CB  . LEU A 1 140 ? 31.825 -26.600 -8.630  1.00 25.53 ? 140 LEU A CB  1 
ATOM   1099 C CG  . LEU A 1 140 ? 32.312 -27.357 -7.393  1.00 25.77 ? 140 LEU A CG  1 
ATOM   1100 C CD1 . LEU A 1 140 ? 31.703 -28.764 -7.350  1.00 30.50 ? 140 LEU A CD1 1 
ATOM   1101 C CD2 . LEU A 1 140 ? 33.839 -27.459 -7.426  1.00 23.22 ? 140 LEU A CD2 1 
ATOM   1102 N N   . LYS A 1 141 ? 31.232 -23.571 -10.107 1.00 25.46 ? 141 LYS A N   1 
ATOM   1103 C CA  . LYS A 1 141 ? 30.532 -23.031 -11.256 1.00 30.96 ? 141 LYS A CA  1 
ATOM   1104 C C   . LYS A 1 141 ? 31.114 -21.692 -11.685 1.00 31.18 ? 141 LYS A C   1 
ATOM   1105 O O   . LYS A 1 141 ? 31.760 -20.977 -10.912 1.00 26.47 ? 141 LYS A O   1 
ATOM   1106 C CB  . LYS A 1 141 ? 29.030 -22.914 -10.971 1.00 35.78 ? 141 LYS A CB  1 
ATOM   1107 C CG  . LYS A 1 141 ? 28.353 -24.277 -10.777 1.00 32.24 ? 141 LYS A CG  1 
ATOM   1108 C CD  . LYS A 1 141 ? 27.014 -24.118 -10.107 1.00 37.90 ? 141 LYS A CD  1 
ATOM   1109 C CE  . LYS A 1 141 ? 26.379 -25.461 -9.775  1.00 45.29 ? 141 LYS A CE  1 
ATOM   1110 N NZ  . LYS A 1 141 ? 24.884 -25.444 -9.933  1.00 48.27 ? 141 LYS A NZ  1 
ATOM   1111 N N   . ARG A 1 142 ? 30.887 -21.381 -12.956 1.00 31.77 ? 142 ARG A N   1 
ATOM   1112 C CA  . ARG A 1 142 ? 31.344 -20.137 -13.562 1.00 37.19 ? 142 ARG A CA  1 
ATOM   1113 C C   . ARG A 1 142 ? 30.771 -18.904 -12.852 1.00 42.94 ? 142 ARG A C   1 
ATOM   1114 O O   . ARG A 1 142 ? 31.502 -17.962 -12.513 1.00 43.70 ? 142 ARG A O   1 
ATOM   1115 C CB  . ARG A 1 142 ? 30.949 -20.117 -15.034 1.00 36.26 ? 142 ARG A CB  1 
ATOM   1116 C CG  . ARG A 1 142 ? 31.896 -19.348 -15.895 1.00 38.00 ? 142 ARG A CG  1 
ATOM   1117 C CD  . ARG A 1 142 ? 31.692 -19.672 -17.367 1.00 44.37 ? 142 ARG A CD  1 
ATOM   1118 N NE  . ARG A 1 142 ? 32.796 -19.138 -18.157 1.00 49.90 ? 142 ARG A NE  1 
ATOM   1119 C CZ  . ARG A 1 142 ? 34.035 -19.628 -18.144 1.00 46.22 ? 142 ARG A CZ  1 
ATOM   1120 N NH1 . ARG A 1 142 ? 34.971 -19.046 -18.878 1.00 37.18 ? 142 ARG A NH1 1 
ATOM   1121 N NH2 . ARG A 1 142 ? 34.337 -20.715 -17.425 1.00 39.16 ? 142 ARG A NH2 1 
HETATM 1122 O O   . HOH B 2 .   ? 29.738 -30.412 14.498  1.00 33.32 ? 201 HOH A O   1 
HETATM 1123 O O   . HOH B 2 .   ? 34.830 -25.149 16.991  1.00 25.75 ? 202 HOH A O   1 
HETATM 1124 O O   . HOH B 2 .   ? 25.795 -14.450 -9.615  1.00 31.01 ? 203 HOH A O   1 
HETATM 1125 O O   . HOH B 2 .   ? 32.112 -21.143 -8.629  1.00 27.19 ? 204 HOH A O   1 
HETATM 1126 O O   . HOH B 2 .   ? 18.042 -31.698 1.124   1.00 26.67 ? 205 HOH A O   1 
HETATM 1127 O O   . HOH B 2 .   ? 16.880 -27.555 26.545  1.00 24.85 ? 206 HOH A O   1 
HETATM 1128 O O   . HOH B 2 .   ? 23.060 -11.124 -1.660  1.00 13.39 ? 207 HOH A O   1 
HETATM 1129 O O   . HOH B 2 .   ? 11.224 -13.046 -4.763  1.00 29.37 ? 208 HOH A O   1 
HETATM 1130 O O   . HOH B 2 .   ? 31.229 -33.711 5.612   1.00 54.48 ? 209 HOH A O   1 
HETATM 1131 O O   . HOH B 2 .   ? 25.196 -30.768 2.753   1.00 32.91 ? 210 HOH A O   1 
HETATM 1132 O O   . HOH B 2 .   ? 30.159 -10.663 11.451  1.00 17.95 ? 211 HOH A O   1 
HETATM 1133 O O   . HOH B 2 .   ? 19.274 0.539   11.229  1.00 31.47 ? 212 HOH A O   1 
HETATM 1134 O O   . HOH B 2 .   ? 35.095 -11.881 -3.534  1.00 22.85 ? 213 HOH A O   1 
HETATM 1135 O O   . HOH B 2 .   ? 38.691 -10.312 9.630   1.00 32.58 ? 214 HOH A O   1 
HETATM 1136 O O   . HOH B 2 .   ? 30.815 -28.984 21.034  1.00 34.01 ? 215 HOH A O   1 
HETATM 1137 O O   . HOH B 2 .   ? 38.684 -6.824  2.245   1.00 21.31 ? 216 HOH A O   1 
HETATM 1138 O O   . HOH B 2 .   ? 32.562 -27.693 -2.267  1.00 23.81 ? 217 HOH A O   1 
HETATM 1139 O O   . HOH B 2 .   ? 15.989 -17.504 -6.900  1.00 28.40 ? 218 HOH A O   1 
HETATM 1140 O O   . HOH B 2 .   ? 15.496 -11.302 -5.717  1.00 23.88 ? 219 HOH A O   1 
HETATM 1141 O O   . HOH B 2 .   ? 31.803 -19.510 -4.659  1.00 16.06 ? 220 HOH A O   1 
HETATM 1142 O O   . HOH B 2 .   ? 30.200 -24.168 -6.697  1.00 26.94 ? 221 HOH A O   1 
HETATM 1143 O O   . HOH B 2 .   ? 21.061 -28.367 16.882  1.00 23.32 ? 222 HOH A O   1 
HETATM 1144 O O   . HOH B 2 .   ? 16.011 -25.029 -4.531  1.00 16.18 ? 223 HOH A O   1 
HETATM 1145 O O   . HOH B 2 .   ? 13.233 -29.155 1.900   1.00 22.19 ? 224 HOH A O   1 
HETATM 1146 O O   . HOH B 2 .   ? 15.333 -21.681 23.460  1.00 23.64 ? 225 HOH A O   1 
HETATM 1147 O O   . HOH B 2 .   ? 20.321 -17.866 28.837  1.00 19.14 ? 226 HOH A O   1 
HETATM 1148 O O   . HOH B 2 .   ? 15.462 -21.220 30.249  1.00 35.79 ? 227 HOH A O   1 
HETATM 1149 O O   . HOH B 2 .   ? 36.056 -19.499 0.915   1.00 17.86 ? 228 HOH A O   1 
HETATM 1150 O O   . HOH B 2 .   ? 10.476 -7.906  7.175   1.00 32.66 ? 229 HOH A O   1 
HETATM 1151 O O   . HOH B 2 .   ? 13.386 -27.618 17.869  1.00 32.65 ? 230 HOH A O   1 
HETATM 1152 O O   . HOH B 2 .   ? 32.491 -11.110 15.002  1.00 33.31 ? 231 HOH A O   1 
HETATM 1153 O O   . HOH B 2 .   ? 29.805 -26.207 0.272   1.00 11.71 ? 232 HOH A O   1 
HETATM 1154 O O   . HOH B 2 .   ? 35.344 -25.811 -2.134  1.00 20.92 ? 233 HOH A O   1 
HETATM 1155 O O   . HOH B 2 .   ? 25.955 -28.621 1.325   1.00 23.89 ? 234 HOH A O   1 
HETATM 1156 O O   . HOH B 2 .   ? 33.205 -11.484 -6.099  1.00 27.92 ? 235 HOH A O   1 
HETATM 1157 O O   . HOH B 2 .   ? 20.982 -24.533 0.473   1.00 41.97 ? 236 HOH A O   1 
HETATM 1158 O O   . HOH B 2 .   ? 32.345 -16.487 -10.451 1.00 37.52 ? 237 HOH A O   1 
HETATM 1159 O O   . HOH B 2 .   ? 32.377 -5.788  -2.058  1.00 23.57 ? 238 HOH A O   1 
HETATM 1160 O O   . HOH B 2 .   ? 34.135 -19.992 20.600  1.00 24.04 ? 239 HOH A O   1 
HETATM 1161 O O   . HOH B 2 .   ? 17.988 -3.225  1.739   1.00 28.62 ? 240 HOH A O   1 
HETATM 1162 O O   . HOH B 2 .   ? 13.084 -14.984 0.098   1.00 14.34 ? 241 HOH A O   1 
HETATM 1163 O O   . HOH B 2 .   ? 16.357 -30.935 11.962  1.00 27.13 ? 242 HOH A O   1 
HETATM 1164 O O   . HOH B 2 .   ? 33.216 -22.618 20.100  1.00 22.28 ? 243 HOH A O   1 
HETATM 1165 O O   . HOH B 2 .   ? 40.138 -18.992 7.022   1.00 17.63 ? 244 HOH A O   1 
HETATM 1166 O O   . HOH B 2 .   ? 11.733 -15.298 -3.081  1.00 22.07 ? 245 HOH A O   1 
HETATM 1167 O O   . HOH B 2 .   ? 22.212 -15.423 -11.724 1.00 31.38 ? 246 HOH A O   1 
HETATM 1168 O O   . HOH B 2 .   ? 31.725 -2.506  1.415   1.00 27.13 ? 247 HOH A O   1 
HETATM 1169 O O   . HOH B 2 .   ? 30.890 -27.364 -12.401 1.00 32.33 ? 248 HOH A O   1 
HETATM 1170 O O   . HOH B 2 .   ? 15.746 -9.531  1.226   1.00 14.94 ? 249 HOH A O   1 
HETATM 1171 O O   . HOH B 2 .   ? 40.151 -22.768 8.046   1.00 31.84 ? 250 HOH A O   1 
HETATM 1172 O O   . HOH B 2 .   ? 19.360 -24.934 -2.733  1.00 33.55 ? 251 HOH A O   1 
HETATM 1173 O O   . HOH B 2 .   ? 24.977 -25.822 -7.224  1.00 42.67 ? 252 HOH A O   1 
HETATM 1174 O O   . HOH B 2 .   ? 38.434 -11.872 0.202   1.00 23.89 ? 253 HOH A O   1 
HETATM 1175 O O   . HOH B 2 .   ? 37.241 -17.850 20.770  1.00 32.37 ? 254 HOH A O   1 
HETATM 1176 O O   . HOH B 2 .   ? 21.902 0.156   12.259  1.00 23.76 ? 255 HOH A O   1 
HETATM 1177 O O   . HOH B 2 .   ? 15.592 -30.365 9.384   1.00 26.98 ? 256 HOH A O   1 
HETATM 1178 O O   . HOH B 2 .   ? 28.231 -28.736 22.498  1.00 29.94 ? 257 HOH A O   1 
HETATM 1179 O O   . HOH B 2 .   ? 21.696 -9.456  0.005   1.00 13.87 ? 258 HOH A O   1 
HETATM 1180 O O   . HOH B 2 .   ? 31.381 -12.611 -3.954  1.00 15.07 ? 259 HOH A O   1 
HETATM 1181 O O   . HOH B 2 .   ? 14.542 -29.749 19.621  1.00 30.69 ? 260 HOH A O   1 
HETATM 1182 O O   . HOH B 2 .   ? 20.137 -8.792  13.906  1.00 25.59 ? 261 HOH A O   1 
HETATM 1183 O O   . HOH B 2 .   ? 15.569 -7.640  -2.845  1.00 27.52 ? 262 HOH A O   1 
HETATM 1184 O O   . HOH B 2 .   ? 31.981 -18.269 20.504  1.00 18.01 ? 263 HOH A O   1 
HETATM 1185 O O   . HOH B 2 .   ? 18.299 -3.866  -2.134  1.00 30.41 ? 264 HOH A O   1 
HETATM 1186 O O   . HOH B 2 .   ? 38.656 -17.332 16.677  1.00 29.56 ? 265 HOH A O   1 
HETATM 1187 O O   . HOH B 2 .   ? 24.404 -10.782 -9.117  1.00 25.62 ? 266 HOH A O   1 
HETATM 1188 O O   . HOH B 2 .   ? 13.070 -7.864  3.135   1.00 24.96 ? 267 HOH A O   1 
HETATM 1189 O O   . HOH B 2 .   ? 16.424 -8.524  16.615  1.00 34.24 ? 268 HOH A O   1 
HETATM 1190 O O   . HOH B 2 .   ? 21.826 -27.707 21.951  1.00 22.21 ? 269 HOH A O   1 
HETATM 1191 O O   . HOH B 2 .   ? 22.018 -26.755 -0.538  1.00 34.97 ? 270 HOH A O   1 
HETATM 1192 O O   . HOH B 2 .   ? 27.977 -18.210 -11.005 1.00 32.65 ? 271 HOH A O   1 
HETATM 1193 O O   . HOH B 2 .   ? 30.171 -8.310  -10.105 1.00 42.06 ? 272 HOH A O   1 
HETATM 1194 O O   . HOH B 2 .   ? 32.311 -4.931  14.451  1.00 34.54 ? 273 HOH A O   1 
HETATM 1195 O O   . HOH B 2 .   ? 16.505 -33.102 20.767  1.00 30.43 ? 274 HOH A O   1 
HETATM 1196 O O   . HOH B 2 .   ? 28.763 -2.050  8.125   1.00 20.87 ? 275 HOH A O   1 
HETATM 1197 O O   . HOH B 2 .   ? 9.569  -24.979 13.713  1.00 26.37 ? 276 HOH A O   1 
HETATM 1198 O O   . HOH B 2 .   ? 29.376 -19.346 24.650  1.00 13.01 ? 277 HOH A O   1 
HETATM 1199 O O   . HOH B 2 .   ? 30.983 -29.465 16.816  1.00 28.80 ? 278 HOH A O   1 
HETATM 1200 O O   . HOH B 2 .   ? 29.780 -17.193 21.940  0.50 17.76 ? 279 HOH A O   1 
HETATM 1201 O O   . HOH B 2 .   ? 31.975 -13.826 -6.982  1.00 23.05 ? 280 HOH A O   1 
HETATM 1202 O O   . HOH B 2 .   ? 21.350 -29.014 5.442   1.00 21.93 ? 281 HOH A O   1 
HETATM 1203 O O   . HOH B 2 .   ? 12.912 -16.894 -7.058  1.00 28.38 ? 282 HOH A O   1 
HETATM 1204 O O   . HOH B 2 .   ? 9.543  -10.685 9.566   1.00 32.71 ? 283 HOH A O   1 
HETATM 1205 O O   . HOH B 2 .   ? 10.805 -8.220  12.923  1.00 37.76 ? 284 HOH A O   1 
HETATM 1206 O O   . HOH B 2 .   ? 34.634 -26.243 -4.803  1.00 24.40 ? 285 HOH A O   1 
HETATM 1207 O O   . HOH B 2 .   ? 20.786 -13.257 -10.520 1.00 35.49 ? 286 HOH A O   1 
HETATM 1208 O O   . HOH B 2 .   ? 21.677 2.567   3.047   1.00 31.90 ? 287 HOH A O   1 
HETATM 1209 O O   . HOH B 2 .   ? 13.835 -4.115  10.975  1.00 30.20 ? 288 HOH A O   1 
HETATM 1210 O O   . HOH B 2 .   ? 30.235 -5.862  12.962  1.00 27.78 ? 289 HOH A O   1 
HETATM 1211 O O   . HOH B 2 .   ? 18.124 -7.623  12.381  1.00 28.63 ? 290 HOH A O   1 
HETATM 1212 O O   . HOH B 2 .   ? 16.591 -2.554  11.726  1.00 40.06 ? 291 HOH A O   1 
HETATM 1213 O O   . HOH B 2 .   ? 26.307 -15.188 21.940  0.50 18.05 ? 292 HOH A O   1 
HETATM 1214 O O   . HOH B 2 .   ? 24.846 -0.313  13.050  1.00 29.87 ? 293 HOH A O   1 
HETATM 1215 O O   . HOH B 2 .   ? 33.772 -16.865 -16.658 1.00 35.15 ? 294 HOH A O   1 
HETATM 1216 O O   . HOH B 2 .   ? 32.257 -32.880 1.647   1.00 49.16 ? 295 HOH A O   1 
HETATM 1217 O O   . HOH B 2 .   ? 22.714 -14.663 -7.468  1.00 34.93 ? 296 HOH A O   1 
HETATM 1218 O O   . HOH B 2 .   ? 19.650 -29.825 14.565  1.00 25.71 ? 297 HOH A O   1 
HETATM 1219 O O   . HOH B 2 .   ? 27.364 -24.933 28.343  1.00 35.61 ? 298 HOH A O   1 
HETATM 1220 O O   . HOH B 2 .   ? 31.699 -1.913  4.074   1.00 22.52 ? 299 HOH A O   1 
HETATM 1221 O O   . HOH B 2 .   ? 23.844 -34.916 17.054  1.00 37.06 ? 300 HOH A O   1 
HETATM 1222 O O   . HOH B 2 .   ? 35.976 -23.763 1.597   1.00 17.83 ? 301 HOH A O   1 
HETATM 1223 O O   . HOH B 2 .   ? 19.142 -9.399  16.177  1.00 28.80 ? 302 HOH A O   1 
HETATM 1224 O O   . HOH B 2 .   ? 39.066 -18.594 11.151  1.00 31.76 ? 303 HOH A O   1 
HETATM 1225 O O   . HOH B 2 .   ? 12.472 -13.755 2.918   1.00 33.79 ? 304 HOH A O   1 
HETATM 1226 O O   . HOH B 2 .   ? 38.342 -6.308  11.350  1.00 32.98 ? 305 HOH A O   1 
HETATM 1227 O O   . HOH B 2 .   ? 23.911 -4.969  -5.871  1.00 22.12 ? 306 HOH A O   1 
HETATM 1228 O O   . HOH B 2 .   ? 30.196 0.604   5.231   1.00 36.09 ? 307 HOH A O   1 
HETATM 1229 O O   . HOH B 2 .   ? 18.129 -14.317 16.791  1.00 24.56 ? 308 HOH A O   1 
HETATM 1230 O O   . HOH B 2 .   ? 29.205 -23.232 -14.594 1.00 32.68 ? 309 HOH A O   1 
HETATM 1231 O O   . HOH B 2 .   ? 37.470 -21.918 19.204  1.00 34.18 ? 310 HOH A O   1 
HETATM 1232 O O   . HOH B 2 .   ? 24.258 -29.089 21.951  1.00 25.04 ? 311 HOH A O   1 
HETATM 1233 O O   . HOH B 2 .   ? 37.074 -17.062 -19.655 1.00 32.35 ? 312 HOH A O   1 
HETATM 1234 O O   . HOH B 2 .   ? 33.832 -8.126  -4.331  1.00 29.18 ? 313 HOH A O   1 
HETATM 1235 O O   . HOH B 2 .   ? 37.159 -29.665 8.902   1.00 37.84 ? 314 HOH A O   1 
HETATM 1236 O O   . HOH B 2 .   ? 12.820 -17.238 5.389   1.00 20.69 ? 315 HOH A O   1 
HETATM 1237 O O   . HOH B 2 .   ? 25.445 -21.363 -11.717 1.00 36.21 ? 316 HOH A O   1 
HETATM 1238 O O   . HOH B 2 .   ? 36.183 -27.757 7.147   1.00 21.05 ? 317 HOH A O   1 
HETATM 1239 O O   . HOH B 2 .   ? 7.661  -11.988 11.071  1.00 35.04 ? 318 HOH A O   1 
HETATM 1240 O O   . HOH B 2 .   ? 29.809 -13.786 -10.980 1.00 34.88 ? 319 HOH A O   1 
HETATM 1241 O O   . HOH B 2 .   ? 28.386 1.624   11.440  1.00 39.96 ? 320 HOH A O   1 
HETATM 1242 O O   . HOH B 2 .   ? 13.688 -11.609 1.689   1.00 13.53 ? 321 HOH A O   1 
HETATM 1243 O O   . HOH B 2 .   ? 25.337 4.029   9.462   1.00 38.44 ? 322 HOH A O   1 
HETATM 1244 O O   . HOH B 2 .   ? 29.736 -21.572 -7.515  1.00 26.89 ? 323 HOH A O   1 
HETATM 1245 O O   . HOH B 2 .   ? 11.087 -28.084 16.440  1.00 39.03 ? 324 HOH A O   1 
HETATM 1246 O O   . HOH B 2 .   ? 15.901 -18.291 -11.041 1.00 29.85 ? 325 HOH A O   1 
HETATM 1247 O O   . HOH B 2 .   ? 21.893 -21.990 -7.877  1.00 28.69 ? 326 HOH A O   1 
HETATM 1248 O O   . HOH B 2 .   ? 36.872 -10.514 13.144  1.00 39.73 ? 327 HOH A O   1 
HETATM 1249 O O   . HOH B 2 .   ? 15.690 -3.629  3.752   1.00 31.12 ? 328 HOH A O   1 
HETATM 1250 O O   . HOH B 2 .   ? 23.350 -22.619 -10.161 1.00 39.11 ? 329 HOH A O   1 
HETATM 1251 O O   . HOH B 2 .   ? 32.091 -18.559 -7.072  1.00 27.23 ? 330 HOH A O   1 
HETATM 1252 O O   . HOH B 2 .   ? 37.710 -20.402 20.974  1.00 40.04 ? 331 HOH A O   1 
HETATM 1253 O O   . HOH B 2 .   ? 22.821 -8.306  15.991  1.00 35.21 ? 332 HOH A O   1 
HETATM 1254 O O   . HOH B 2 .   ? 21.218 -6.498  14.427  1.00 34.09 ? 333 HOH A O   1 
HETATM 1255 O O   . HOH B 2 .   ? 39.475 -5.241  4.537   1.00 27.30 ? 334 HOH A O   1 
HETATM 1256 O O   . HOH B 2 .   ? 35.460 -23.938 19.247  1.00 35.86 ? 335 HOH A O   1 
HETATM 1257 O O   . HOH B 2 .   ? 28.193 -26.159 -7.607  1.00 44.86 ? 336 HOH A O   1 
HETATM 1258 O O   . HOH B 2 .   ? 8.982  -26.264 7.373   1.00 29.15 ? 337 HOH A O   1 
HETATM 1259 O O   . HOH B 2 .   ? 14.639 -1.156  4.494   1.00 35.90 ? 338 HOH A O   1 
HETATM 1260 O O   . HOH B 2 .   ? 13.700 -5.049  2.390   1.00 35.72 ? 339 HOH A O   1 
HETATM 1261 O O   . HOH B 2 .   ? 37.634 -12.742 14.834  1.00 46.47 ? 340 HOH A O   1 
HETATM 1262 O O   . HOH B 2 .   ? 28.557 -28.018 -1.473  1.00 30.12 ? 341 HOH A O   1 
HETATM 1263 O O   . HOH B 2 .   ? 16.650 -33.612 12.557  1.00 38.18 ? 342 HOH A O   1 
HETATM 1264 O O   . HOH B 2 .   ? 14.046 -26.698 26.641  1.00 38.28 ? 343 HOH A O   1 
HETATM 1265 O O   . HOH B 2 .   ? 14.451 -7.733  -0.380  1.00 25.04 ? 344 HOH A O   1 
HETATM 1266 O O   . HOH B 2 .   ? 32.038 -14.453 -9.635  1.00 38.02 ? 345 HOH A O   1 
HETATM 1267 O O   . HOH B 2 .   ? 41.867 -15.195 5.491   1.00 41.61 ? 346 HOH A O   1 
HETATM 1268 O O   . HOH B 2 .   ? 28.350 -27.830 -9.640  1.00 41.18 ? 347 HOH A O   1 
HETATM 1269 O O   . HOH B 2 .   ? 20.530 -30.340 1.211   1.00 40.95 ? 348 HOH A O   1 
HETATM 1270 O O   . HOH B 2 .   ? 12.699 -32.187 3.905   1.00 54.24 ? 349 HOH A O   1 
HETATM 1271 O O   . HOH B 2 .   ? 20.568 -8.637  -6.837  1.00 32.46 ? 350 HOH A O   1 
HETATM 1272 O O   . HOH B 2 .   ? 34.521 -1.379  5.170   1.00 33.17 ? 351 HOH A O   1 
HETATM 1273 O O   . HOH B 2 .   ? 11.258 -3.517  2.395   1.00 41.95 ? 352 HOH A O   1 
HETATM 1274 O O   . HOH B 2 .   ? 41.378 -25.795 12.927  1.00 31.66 ? 353 HOH A O   1 
HETATM 1275 O O   . HOH B 2 .   ? 40.758 -21.313 10.437  1.00 40.85 ? 354 HOH A O   1 
HETATM 1276 O O   . HOH B 2 .   ? 26.529 -29.601 -1.138  1.00 31.43 ? 355 HOH A O   1 
HETATM 1277 O O   . HOH B 2 .   ? 16.487 -30.926 -1.433  1.00 32.41 ? 356 HOH A O   1 
HETATM 1278 O O   . HOH B 2 .   ? 30.219 -28.648 -3.524  1.00 28.84 ? 357 HOH A O   1 
HETATM 1279 O O   . HOH B 2 .   ? 9.000  -9.972  6.778   1.00 30.63 ? 358 HOH A O   1 
HETATM 1280 O O   . HOH B 2 .   ? 23.257 5.697   8.608   1.00 30.43 ? 359 HOH A O   1 
HETATM 1281 O O   . HOH B 2 .   ? 38.755 -15.103 18.673  1.00 40.87 ? 360 HOH A O   1 
HETATM 1282 O O   . HOH B 2 .   ? 17.423 -28.576 29.010  1.00 32.88 ? 361 HOH A O   1 
HETATM 1283 O O   . HOH B 2 .   ? 10.236 -13.762 4.026   1.00 21.21 ? 362 HOH A O   1 
HETATM 1284 O O   . HOH B 2 .   ? 34.248 -25.074 21.238  1.00 41.04 ? 363 HOH A O   1 
HETATM 1285 O O   . HOH B 2 .   ? 29.425 -22.673 -17.379 1.00 40.89 ? 364 HOH A O   1 
HETATM 1286 O O   . HOH B 2 .   ? 28.381 -26.017 -14.228 1.00 43.78 ? 365 HOH A O   1 
HETATM 1287 O O   . HOH B 2 .   ? 11.689 -9.679  1.226   1.00 38.86 ? 366 HOH A O   1 
HETATM 1288 O O   . HOH B 2 .   ? 16.415 -3.713  -0.581  1.00 35.57 ? 367 HOH A O   1 
HETATM 1289 O O   . HOH B 2 .   ? 23.361 -8.146  -9.817  1.00 35.02 ? 368 HOH A O   1 
HETATM 1290 O O   . HOH B 2 .   ? 32.466 0.915   12.886  1.00 39.63 ? 369 HOH A O   1 
HETATM 1291 O O   . HOH B 2 .   ? 43.474 -24.629 13.829  1.00 40.78 ? 370 HOH A O   1 
HETATM 1292 O O   . HOH B 2 .   ? 30.788 -30.985 -4.006  1.00 36.25 ? 371 HOH A O   1 
HETATM 1293 O O   . HOH B 2 .   ? 33.595 -31.243 -4.534  1.00 30.24 ? 372 HOH A O   1 
# 
