data_8YPF
# 
_entry.id   8YPF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YPF         pdb_00008ypf 10.2210/pdb8ypf/pdb 
WWPDB D_1300045005 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-19 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YPF 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 jiaweiwu@suda.edu.cn            Jia-Wei Wu   ? 'principal investigator/group leader' 0000-0003-0273-1686 
3 zhixinwang@mail.tsinghua.edu.cn Zhi-Xin Wang ? 'principal investigator/group leader' 0000-0003-4656-2941 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, Y.Y.' 1 ? 
'Pei, C.J.'   2 ? 
'He, Q.Q.'    3 ? 
'Luo, Z.P.'   4 ? 
'Wu, J.W.'    5 ? 
'Wang, Z.X.'  6 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural and mechanistic insights into the allosteric activation of p38alpha MAP kinase via specific docking interactions' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, Y.Y.' 1 ? 
primary 'Pei, C.J.'   2 ? 
primary 'He, Q.Q.'    3 ? 
primary 'Luo, Z.P.'   4 ? 
primary 'Wu, J.W.'    5 ? 
primary 'Wang, Z.X.'  6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Mitogen-activated protein kinase 14'             41338.160 1   2.7.11.24 ? ? ? 
2 polymer man 'Cyclic AMP-dependent transcription factor ATF-2' 5078.776  1   ?         ? ? ? 
3 water   nat water                                             18.015    230 ?         ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'MAP kinase 14,MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha' 
2 
;cAMP-dependent transcription factor ATF-2,Activating transcription factor 2,Cyclic AMP-responsive element-binding protein 2,CREB-2,cAMP-responsive element-binding protein 2,HB16,cAMP response element-binding protein CRE-BP1
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH
ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA
DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
;MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH
ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA
DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
A ? 
2 'polypeptide(L)' no no KHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS KHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS B ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   GLN n 
1 4   GLU n 
1 5   ARG n 
1 6   PRO n 
1 7   THR n 
1 8   PHE n 
1 9   TYR n 
1 10  ARG n 
1 11  GLN n 
1 12  GLU n 
1 13  LEU n 
1 14  ASN n 
1 15  LYS n 
1 16  THR n 
1 17  ILE n 
1 18  TRP n 
1 19  GLU n 
1 20  VAL n 
1 21  PRO n 
1 22  GLU n 
1 23  ARG n 
1 24  TYR n 
1 25  GLN n 
1 26  ASN n 
1 27  LEU n 
1 28  SER n 
1 29  PRO n 
1 30  VAL n 
1 31  GLY n 
1 32  SER n 
1 33  GLY n 
1 34  ALA n 
1 35  TYR n 
1 36  GLY n 
1 37  SER n 
1 38  VAL n 
1 39  CYS n 
1 40  ALA n 
1 41  ALA n 
1 42  PHE n 
1 43  ASP n 
1 44  THR n 
1 45  LYS n 
1 46  THR n 
1 47  GLY n 
1 48  HIS n 
1 49  ARG n 
1 50  VAL n 
1 51  ALA n 
1 52  VAL n 
1 53  LYS n 
1 54  LYS n 
1 55  LEU n 
1 56  SER n 
1 57  ARG n 
1 58  PRO n 
1 59  PHE n 
1 60  GLN n 
1 61  SER n 
1 62  ILE n 
1 63  ILE n 
1 64  HIS n 
1 65  ALA n 
1 66  LYS n 
1 67  ARG n 
1 68  THR n 
1 69  TYR n 
1 70  ARG n 
1 71  GLU n 
1 72  LEU n 
1 73  ARG n 
1 74  LEU n 
1 75  LEU n 
1 76  LYS n 
1 77  HIS n 
1 78  MET n 
1 79  LYS n 
1 80  HIS n 
1 81  GLU n 
1 82  ASN n 
1 83  VAL n 
1 84  ILE n 
1 85  GLY n 
1 86  LEU n 
1 87  LEU n 
1 88  ASP n 
1 89  VAL n 
1 90  PHE n 
1 91  THR n 
1 92  PRO n 
1 93  ALA n 
1 94  ARG n 
1 95  SER n 
1 96  LEU n 
1 97  GLU n 
1 98  GLU n 
1 99  PHE n 
1 100 ASN n 
1 101 ASP n 
1 102 VAL n 
1 103 TYR n 
1 104 LEU n 
1 105 VAL n 
1 106 THR n 
1 107 HIS n 
1 108 LEU n 
1 109 MET n 
1 110 GLY n 
1 111 ALA n 
1 112 ASP n 
1 113 LEU n 
1 114 ASN n 
1 115 ASN n 
1 116 ILE n 
1 117 VAL n 
1 118 LYS n 
1 119 CYS n 
1 120 GLN n 
1 121 LYS n 
1 122 LEU n 
1 123 THR n 
1 124 ASP n 
1 125 ASP n 
1 126 HIS n 
1 127 VAL n 
1 128 GLN n 
1 129 PHE n 
1 130 LEU n 
1 131 ILE n 
1 132 TYR n 
1 133 GLN n 
1 134 ILE n 
1 135 LEU n 
1 136 ARG n 
1 137 GLY n 
1 138 LEU n 
1 139 LYS n 
1 140 TYR n 
1 141 ILE n 
1 142 HIS n 
1 143 SER n 
1 144 ALA n 
1 145 ASP n 
1 146 ILE n 
1 147 ILE n 
1 148 HIS n 
1 149 ARG n 
1 150 ASP n 
1 151 LEU n 
1 152 LYS n 
1 153 PRO n 
1 154 SER n 
1 155 ASN n 
1 156 LEU n 
1 157 ALA n 
1 158 VAL n 
1 159 ASN n 
1 160 GLU n 
1 161 ASP n 
1 162 CYS n 
1 163 GLU n 
1 164 LEU n 
1 165 LYS n 
1 166 ILE n 
1 167 LEU n 
1 168 ASP n 
1 169 PHE n 
1 170 GLY n 
1 171 LEU n 
1 172 ALA n 
1 173 ARG n 
1 174 HIS n 
1 175 THR n 
1 176 ASP n 
1 177 ASP n 
1 178 GLU n 
1 179 MET n 
1 180 THR n 
1 181 GLY n 
1 182 TYR n 
1 183 VAL n 
1 184 ALA n 
1 185 THR n 
1 186 ARG n 
1 187 TRP n 
1 188 TYR n 
1 189 ARG n 
1 190 ALA n 
1 191 PRO n 
1 192 GLU n 
1 193 ILE n 
1 194 MET n 
1 195 LEU n 
1 196 ASN n 
1 197 TRP n 
1 198 MET n 
1 199 HIS n 
1 200 TYR n 
1 201 ASN n 
1 202 GLN n 
1 203 THR n 
1 204 VAL n 
1 205 ASP n 
1 206 ILE n 
1 207 TRP n 
1 208 SER n 
1 209 VAL n 
1 210 GLY n 
1 211 CYS n 
1 212 ILE n 
1 213 MET n 
1 214 ALA n 
1 215 GLU n 
1 216 LEU n 
1 217 LEU n 
1 218 THR n 
1 219 GLY n 
1 220 ARG n 
1 221 THR n 
1 222 LEU n 
1 223 PHE n 
1 224 PRO n 
1 225 GLY n 
1 226 THR n 
1 227 ASP n 
1 228 HIS n 
1 229 ILE n 
1 230 ASP n 
1 231 GLN n 
1 232 LEU n 
1 233 LYS n 
1 234 LEU n 
1 235 ILE n 
1 236 LEU n 
1 237 ARG n 
1 238 LEU n 
1 239 VAL n 
1 240 GLY n 
1 241 THR n 
1 242 PRO n 
1 243 GLY n 
1 244 ALA n 
1 245 GLU n 
1 246 LEU n 
1 247 LEU n 
1 248 LYS n 
1 249 LYS n 
1 250 ILE n 
1 251 SER n 
1 252 SER n 
1 253 GLU n 
1 254 SER n 
1 255 ALA n 
1 256 ARG n 
1 257 ASN n 
1 258 TYR n 
1 259 ILE n 
1 260 GLN n 
1 261 SER n 
1 262 LEU n 
1 263 ALA n 
1 264 GLN n 
1 265 MET n 
1 266 PRO n 
1 267 LYS n 
1 268 MET n 
1 269 ASN n 
1 270 PHE n 
1 271 ALA n 
1 272 ASN n 
1 273 VAL n 
1 274 PHE n 
1 275 ILE n 
1 276 GLY n 
1 277 ALA n 
1 278 ASN n 
1 279 PRO n 
1 280 LEU n 
1 281 ALA n 
1 282 VAL n 
1 283 ASP n 
1 284 LEU n 
1 285 LEU n 
1 286 GLU n 
1 287 LYS n 
1 288 MET n 
1 289 LEU n 
1 290 VAL n 
1 291 LEU n 
1 292 ASP n 
1 293 SER n 
1 294 ASP n 
1 295 LYS n 
1 296 ARG n 
1 297 ILE n 
1 298 THR n 
1 299 ALA n 
1 300 ALA n 
1 301 GLN n 
1 302 ALA n 
1 303 LEU n 
1 304 ALA n 
1 305 HIS n 
1 306 ALA n 
1 307 TYR n 
1 308 PHE n 
1 309 ALA n 
1 310 GLN n 
1 311 TYR n 
1 312 HIS n 
1 313 ASP n 
1 314 PRO n 
1 315 ASP n 
1 316 ASP n 
1 317 GLU n 
1 318 PRO n 
1 319 VAL n 
1 320 ALA n 
1 321 ASP n 
1 322 PRO n 
1 323 TYR n 
1 324 ASP n 
1 325 GLN n 
1 326 SER n 
1 327 PHE n 
1 328 GLU n 
1 329 SER n 
1 330 ARG n 
1 331 ASP n 
1 332 LEU n 
1 333 LEU n 
1 334 ILE n 
1 335 ASP n 
1 336 GLU n 
1 337 TRP n 
1 338 LYS n 
1 339 SER n 
1 340 LEU n 
1 341 THR n 
1 342 TYR n 
1 343 ASP n 
1 344 GLU n 
1 345 VAL n 
1 346 ILE n 
1 347 SER n 
1 348 PHE n 
1 349 VAL n 
1 350 PRO n 
1 351 PRO n 
1 352 PRO n 
1 353 LEU n 
1 354 ASP n 
1 355 GLN n 
1 356 GLU n 
1 357 GLU n 
1 358 MET n 
1 359 GLU n 
1 360 SER n 
2 1   LYS n 
2 2   HIS n 
2 3   LYS n 
2 4   HIS n 
2 5   GLU n 
2 6   MET n 
2 7   THR n 
2 8   LEU n 
2 9   LYS n 
2 10  PHE n 
2 11  GLY n 
2 12  PRO n 
2 13  ALA n 
2 14  ARG n 
2 15  ASN n 
2 16  ASP n 
2 17  SER n 
2 18  VAL n 
2 19  ILE n 
2 20  VAL n 
2 21  ALA n 
2 22  ASP n 
2 23  GLN n 
2 24  THR n 
2 25  PRO n 
2 26  THR n 
2 27  PRO n 
2 28  THR n 
2 29  ARG n 
2 30  PHE n 
2 31  LEU n 
2 32  LYS n 
2 33  ASN n 
2 34  CYS n 
2 35  GLU n 
2 36  GLU n 
2 37  VAL n 
2 38  GLY n 
2 39  LEU n 
2 40  PHE n 
2 41  ASN n 
2 42  GLU n 
2 43  LEU n 
2 44  ALA n 
2 45  SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 360 'house mouse' ? 'Mapk14, Crk1, Csbp1, Csbp2' ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? 
? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 45  human         ? 'ATF2, CREB2, CREBP1'        ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? 
? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   GLN 3   3   ?   ?   ?   A . n 
A 1 4   GLU 4   4   ?   ?   ?   A . n 
A 1 5   ARG 5   5   5   ARG ARG A . n 
A 1 6   PRO 6   6   6   PRO PRO A . n 
A 1 7   THR 7   7   7   THR THR A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   TYR 9   9   9   TYR TYR A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  GLN 11  11  11  GLN GLN A . n 
A 1 12  GLU 12  12  12  GLU GLU A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  ASN 14  14  14  ASN ASN A . n 
A 1 15  LYS 15  15  15  LYS LYS A . n 
A 1 16  THR 16  16  16  THR THR A . n 
A 1 17  ILE 17  17  17  ILE ILE A . n 
A 1 18  TRP 18  18  18  TRP TRP A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  PRO 21  21  21  PRO PRO A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  ARG 23  23  23  ARG ARG A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  GLN 25  25  25  GLN GLN A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  PRO 29  29  29  PRO PRO A . n 
A 1 30  VAL 30  30  30  VAL VAL A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  GLY 33  33  33  GLY GLY A . n 
A 1 34  ALA 34  34  34  ALA ALA A . n 
A 1 35  TYR 35  35  35  TYR TYR A . n 
A 1 36  GLY 36  36  36  GLY GLY A . n 
A 1 37  SER 37  37  37  SER SER A . n 
A 1 38  VAL 38  38  38  VAL VAL A . n 
A 1 39  CYS 39  39  39  CYS CYS A . n 
A 1 40  ALA 40  40  40  ALA ALA A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  PHE 42  42  42  PHE PHE A . n 
A 1 43  ASP 43  43  43  ASP ASP A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  LYS 45  45  45  LYS LYS A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  GLY 47  47  47  GLY GLY A . n 
A 1 48  HIS 48  48  48  HIS HIS A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  VAL 50  50  50  VAL VAL A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  VAL 52  52  52  VAL VAL A . n 
A 1 53  LYS 53  53  53  LYS LYS A . n 
A 1 54  LYS 54  54  54  LYS LYS A . n 
A 1 55  LEU 55  55  55  LEU LEU A . n 
A 1 56  SER 56  56  56  SER SER A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  PRO 58  58  58  PRO PRO A . n 
A 1 59  PHE 59  59  59  PHE PHE A . n 
A 1 60  GLN 60  60  60  GLN GLN A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  ILE 62  62  62  ILE ILE A . n 
A 1 63  ILE 63  63  63  ILE ILE A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ALA 65  65  65  ALA ALA A . n 
A 1 66  LYS 66  66  66  LYS LYS A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  TYR 69  69  69  TYR TYR A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  LEU 74  74  74  LEU LEU A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  HIS 77  77  77  HIS HIS A . n 
A 1 78  MET 78  78  78  MET MET A . n 
A 1 79  LYS 79  79  79  LYS LYS A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  GLU 81  81  81  GLU GLU A . n 
A 1 82  ASN 82  82  82  ASN ASN A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  ASP 88  88  88  ASP ASP A . n 
A 1 89  VAL 89  89  89  VAL VAL A . n 
A 1 90  PHE 90  90  90  PHE PHE A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  PRO 92  92  92  PRO PRO A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  ARG 94  94  94  ARG ARG A . n 
A 1 95  SER 95  95  95  SER SER A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLU 97  97  97  GLU GLU A . n 
A 1 98  GLU 98  98  98  GLU GLU A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 VAL 102 102 102 VAL VAL A . n 
A 1 103 TYR 103 103 103 TYR TYR A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 VAL 105 105 105 VAL VAL A . n 
A 1 106 THR 106 106 106 THR THR A . n 
A 1 107 HIS 107 107 107 HIS HIS A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 MET 109 109 109 MET MET A . n 
A 1 110 GLY 110 110 110 GLY GLY A . n 
A 1 111 ALA 111 111 111 ALA ALA A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 ASN 114 114 114 ASN ASN A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 LYS 118 118 118 LYS LYS A . n 
A 1 119 CYS 119 119 119 CYS CYS A . n 
A 1 120 GLN 120 120 120 GLN GLN A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 THR 123 123 123 THR THR A . n 
A 1 124 ASP 124 124 124 ASP ASP A . n 
A 1 125 ASP 125 125 125 ASP ASP A . n 
A 1 126 HIS 126 126 126 HIS HIS A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 GLN 128 128 128 GLN GLN A . n 
A 1 129 PHE 129 129 129 PHE PHE A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ILE 131 131 131 ILE ILE A . n 
A 1 132 TYR 132 132 132 TYR TYR A . n 
A 1 133 GLN 133 133 133 GLN GLN A . n 
A 1 134 ILE 134 134 134 ILE ILE A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 ARG 136 136 136 ARG ARG A . n 
A 1 137 GLY 137 137 137 GLY GLY A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 LYS 139 139 139 LYS LYS A . n 
A 1 140 TYR 140 140 140 TYR TYR A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 HIS 142 142 142 HIS HIS A . n 
A 1 143 SER 143 143 143 SER SER A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 ILE 147 147 147 ILE ILE A . n 
A 1 148 HIS 148 148 148 HIS HIS A . n 
A 1 149 ARG 149 149 149 ARG ARG A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 ASN 155 155 155 ASN ASN A . n 
A 1 156 LEU 156 156 156 LEU LEU A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 VAL 158 158 158 VAL VAL A . n 
A 1 159 ASN 159 159 159 ASN ASN A . n 
A 1 160 GLU 160 160 160 GLU GLU A . n 
A 1 161 ASP 161 161 161 ASP ASP A . n 
A 1 162 CYS 162 162 162 CYS CYS A . n 
A 1 163 GLU 163 163 163 GLU GLU A . n 
A 1 164 LEU 164 164 164 LEU LEU A . n 
A 1 165 LYS 165 165 165 LYS LYS A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 PHE 169 169 169 PHE PHE A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 LEU 171 171 ?   ?   ?   A . n 
A 1 172 ALA 172 172 ?   ?   ?   A . n 
A 1 173 ARG 173 173 ?   ?   ?   A . n 
A 1 174 HIS 174 174 ?   ?   ?   A . n 
A 1 175 THR 175 175 ?   ?   ?   A . n 
A 1 176 ASP 176 176 ?   ?   ?   A . n 
A 1 177 ASP 177 177 ?   ?   ?   A . n 
A 1 178 GLU 178 178 ?   ?   ?   A . n 
A 1 179 MET 179 179 ?   ?   ?   A . n 
A 1 180 THR 180 180 ?   ?   ?   A . n 
A 1 181 GLY 181 181 ?   ?   ?   A . n 
A 1 182 TYR 182 182 ?   ?   ?   A . n 
A 1 183 VAL 183 183 ?   ?   ?   A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 THR 185 185 185 THR THR A . n 
A 1 186 ARG 186 186 186 ARG ARG A . n 
A 1 187 TRP 187 187 187 TRP TRP A . n 
A 1 188 TYR 188 188 188 TYR TYR A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 GLU 192 192 192 GLU GLU A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 MET 194 194 194 MET MET A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 ASN 196 196 196 ASN ASN A . n 
A 1 197 TRP 197 197 197 TRP TRP A . n 
A 1 198 MET 198 198 198 MET MET A . n 
A 1 199 HIS 199 199 199 HIS HIS A . n 
A 1 200 TYR 200 200 200 TYR TYR A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 GLN 202 202 202 GLN GLN A . n 
A 1 203 THR 203 203 203 THR THR A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ASP 205 205 205 ASP ASP A . n 
A 1 206 ILE 206 206 206 ILE ILE A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 VAL 209 209 209 VAL VAL A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 CYS 211 211 211 CYS CYS A . n 
A 1 212 ILE 212 212 212 ILE ILE A . n 
A 1 213 MET 213 213 213 MET MET A . n 
A 1 214 ALA 214 214 214 ALA ALA A . n 
A 1 215 GLU 215 215 215 GLU GLU A . n 
A 1 216 LEU 216 216 216 LEU LEU A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 THR 218 218 218 THR THR A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 ARG 220 220 220 ARG ARG A . n 
A 1 221 THR 221 221 221 THR THR A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 PRO 224 224 224 PRO PRO A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 ASP 227 227 227 ASP ASP A . n 
A 1 228 HIS 228 228 228 HIS HIS A . n 
A 1 229 ILE 229 229 229 ILE ILE A . n 
A 1 230 ASP 230 230 230 ASP ASP A . n 
A 1 231 GLN 231 231 231 GLN GLN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 LYS 233 233 233 LYS LYS A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ILE 235 235 235 ILE ILE A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 ARG 237 237 237 ARG ARG A . n 
A 1 238 LEU 238 238 238 LEU LEU A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 GLY 240 240 240 GLY GLY A . n 
A 1 241 THR 241 241 241 THR THR A . n 
A 1 242 PRO 242 242 242 PRO PRO A . n 
A 1 243 GLY 243 243 243 GLY GLY A . n 
A 1 244 ALA 244 244 244 ALA ALA A . n 
A 1 245 GLU 245 245 245 GLU GLU A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 LYS 248 248 248 LYS LYS A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 ILE 250 250 250 ILE ILE A . n 
A 1 251 SER 251 251 251 SER SER A . n 
A 1 252 SER 252 252 252 SER SER A . n 
A 1 253 GLU 253 253 253 GLU GLU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 ARG 256 256 256 ARG ARG A . n 
A 1 257 ASN 257 257 257 ASN ASN A . n 
A 1 258 TYR 258 258 258 TYR TYR A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 SER 261 261 261 SER SER A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ALA 263 263 263 ALA ALA A . n 
A 1 264 GLN 264 264 264 GLN GLN A . n 
A 1 265 MET 265 265 265 MET MET A . n 
A 1 266 PRO 266 266 266 PRO PRO A . n 
A 1 267 LYS 267 267 267 LYS LYS A . n 
A 1 268 MET 268 268 268 MET MET A . n 
A 1 269 ASN 269 269 269 ASN ASN A . n 
A 1 270 PHE 270 270 270 PHE PHE A . n 
A 1 271 ALA 271 271 271 ALA ALA A . n 
A 1 272 ASN 272 272 272 ASN ASN A . n 
A 1 273 VAL 273 273 273 VAL VAL A . n 
A 1 274 PHE 274 274 274 PHE PHE A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 GLY 276 276 276 GLY GLY A . n 
A 1 277 ALA 277 277 277 ALA ALA A . n 
A 1 278 ASN 278 278 278 ASN ASN A . n 
A 1 279 PRO 279 279 279 PRO PRO A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 VAL 282 282 282 VAL VAL A . n 
A 1 283 ASP 283 283 283 ASP ASP A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 GLU 286 286 286 GLU GLU A . n 
A 1 287 LYS 287 287 287 LYS LYS A . n 
A 1 288 MET 288 288 288 MET MET A . n 
A 1 289 LEU 289 289 289 LEU LEU A . n 
A 1 290 VAL 290 290 290 VAL VAL A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 ASP 292 292 292 ASP ASP A . n 
A 1 293 SER 293 293 293 SER SER A . n 
A 1 294 ASP 294 294 294 ASP ASP A . n 
A 1 295 LYS 295 295 295 LYS LYS A . n 
A 1 296 ARG 296 296 296 ARG ARG A . n 
A 1 297 ILE 297 297 297 ILE ILE A . n 
A 1 298 THR 298 298 298 THR THR A . n 
A 1 299 ALA 299 299 299 ALA ALA A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 GLN 301 301 301 GLN GLN A . n 
A 1 302 ALA 302 302 302 ALA ALA A . n 
A 1 303 LEU 303 303 303 LEU LEU A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 HIS 305 305 305 HIS HIS A . n 
A 1 306 ALA 306 306 306 ALA ALA A . n 
A 1 307 TYR 307 307 307 TYR TYR A . n 
A 1 308 PHE 308 308 308 PHE PHE A . n 
A 1 309 ALA 309 309 309 ALA ALA A . n 
A 1 310 GLN 310 310 310 GLN GLN A . n 
A 1 311 TYR 311 311 311 TYR TYR A . n 
A 1 312 HIS 312 312 312 HIS HIS A . n 
A 1 313 ASP 313 313 313 ASP ASP A . n 
A 1 314 PRO 314 314 314 PRO PRO A . n 
A 1 315 ASP 315 315 315 ASP ASP A . n 
A 1 316 ASP 316 316 316 ASP ASP A . n 
A 1 317 GLU 317 317 317 GLU GLU A . n 
A 1 318 PRO 318 318 318 PRO PRO A . n 
A 1 319 VAL 319 319 319 VAL VAL A . n 
A 1 320 ALA 320 320 320 ALA ALA A . n 
A 1 321 ASP 321 321 321 ASP ASP A . n 
A 1 322 PRO 322 322 322 PRO PRO A . n 
A 1 323 TYR 323 323 323 TYR TYR A . n 
A 1 324 ASP 324 324 324 ASP ASP A . n 
A 1 325 GLN 325 325 325 GLN GLN A . n 
A 1 326 SER 326 326 326 SER SER A . n 
A 1 327 PHE 327 327 327 PHE PHE A . n 
A 1 328 GLU 328 328 328 GLU GLU A . n 
A 1 329 SER 329 329 329 SER SER A . n 
A 1 330 ARG 330 330 330 ARG ARG A . n 
A 1 331 ASP 331 331 331 ASP ASP A . n 
A 1 332 LEU 332 332 332 LEU LEU A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 ILE 334 334 334 ILE ILE A . n 
A 1 335 ASP 335 335 335 ASP ASP A . n 
A 1 336 GLU 336 336 336 GLU GLU A . n 
A 1 337 TRP 337 337 337 TRP TRP A . n 
A 1 338 LYS 338 338 338 LYS LYS A . n 
A 1 339 SER 339 339 339 SER SER A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 THR 341 341 341 THR THR A . n 
A 1 342 TYR 342 342 342 TYR TYR A . n 
A 1 343 ASP 343 343 343 ASP ASP A . n 
A 1 344 GLU 344 344 344 GLU GLU A . n 
A 1 345 VAL 345 345 345 VAL VAL A . n 
A 1 346 ILE 346 346 346 ILE ILE A . n 
A 1 347 SER 347 347 347 SER SER A . n 
A 1 348 PHE 348 348 348 PHE PHE A . n 
A 1 349 VAL 349 349 349 VAL VAL A . n 
A 1 350 PRO 350 350 350 PRO PRO A . n 
A 1 351 PRO 351 351 351 PRO PRO A . n 
A 1 352 PRO 352 352 352 PRO PRO A . n 
A 1 353 LEU 353 353 353 LEU LEU A . n 
A 1 354 ASP 354 354 ?   ?   ?   A . n 
A 1 355 GLN 355 355 ?   ?   ?   A . n 
A 1 356 GLU 356 356 ?   ?   ?   A . n 
A 1 357 GLU 357 357 ?   ?   ?   A . n 
A 1 358 MET 358 358 ?   ?   ?   A . n 
A 1 359 GLU 359 359 ?   ?   ?   A . n 
A 1 360 SER 360 360 ?   ?   ?   A . n 
B 2 1   LYS 1   46  ?   ?   ?   B . n 
B 2 2   HIS 2   47  ?   ?   ?   B . n 
B 2 3   LYS 3   48  ?   ?   ?   B . n 
B 2 4   HIS 4   49  ?   ?   ?   B . n 
B 2 5   GLU 5   50  50  GLU GLU B . n 
B 2 6   MET 6   51  51  MET MET B . n 
B 2 7   THR 7   52  52  THR THR B . n 
B 2 8   LEU 8   53  53  LEU LEU B . n 
B 2 9   LYS 9   54  54  LYS LYS B . n 
B 2 10  PHE 10  55  55  PHE PHE B . n 
B 2 11  GLY 11  56  56  GLY GLY B . n 
B 2 12  PRO 12  57  ?   ?   ?   B . n 
B 2 13  ALA 13  58  ?   ?   ?   B . n 
B 2 14  ARG 14  59  ?   ?   ?   B . n 
B 2 15  ASN 15  60  ?   ?   ?   B . n 
B 2 16  ASP 16  61  ?   ?   ?   B . n 
B 2 17  SER 17  62  ?   ?   ?   B . n 
B 2 18  VAL 18  63  ?   ?   ?   B . n 
B 2 19  ILE 19  64  ?   ?   ?   B . n 
B 2 20  VAL 20  65  ?   ?   ?   B . n 
B 2 21  ALA 21  66  ?   ?   ?   B . n 
B 2 22  ASP 22  67  ?   ?   ?   B . n 
B 2 23  GLN 23  68  ?   ?   ?   B . n 
B 2 24  THR 24  69  ?   ?   ?   B . n 
B 2 25  PRO 25  70  ?   ?   ?   B . n 
B 2 26  THR 26  71  ?   ?   ?   B . n 
B 2 27  PRO 27  72  ?   ?   ?   B . n 
B 2 28  THR 28  73  ?   ?   ?   B . n 
B 2 29  ARG 29  74  ?   ?   ?   B . n 
B 2 30  PHE 30  75  ?   ?   ?   B . n 
B 2 31  LEU 31  76  ?   ?   ?   B . n 
B 2 32  LYS 32  77  ?   ?   ?   B . n 
B 2 33  ASN 33  78  ?   ?   ?   B . n 
B 2 34  CYS 34  79  ?   ?   ?   B . n 
B 2 35  GLU 35  80  ?   ?   ?   B . n 
B 2 36  GLU 36  81  ?   ?   ?   B . n 
B 2 37  VAL 37  82  ?   ?   ?   B . n 
B 2 38  GLY 38  83  ?   ?   ?   B . n 
B 2 39  LEU 39  84  ?   ?   ?   B . n 
B 2 40  PHE 40  85  ?   ?   ?   B . n 
B 2 41  ASN 41  86  ?   ?   ?   B . n 
B 2 42  GLU 42  87  ?   ?   ?   B . n 
B 2 43  LEU 43  88  ?   ?   ?   B . n 
B 2 44  ALA 44  89  ?   ?   ?   B . n 
B 2 45  SER 45  90  ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   401 173 HOH HOH A . 
C 3 HOH 2   402 208 HOH HOH A . 
C 3 HOH 3   403 178 HOH HOH A . 
C 3 HOH 4   404 20  HOH HOH A . 
C 3 HOH 5   405 65  HOH HOH A . 
C 3 HOH 6   406 103 HOH HOH A . 
C 3 HOH 7   407 64  HOH HOH A . 
C 3 HOH 8   408 19  HOH HOH A . 
C 3 HOH 9   409 137 HOH HOH A . 
C 3 HOH 10  410 76  HOH HOH A . 
C 3 HOH 11  411 100 HOH HOH A . 
C 3 HOH 12  412 58  HOH HOH A . 
C 3 HOH 13  413 174 HOH HOH A . 
C 3 HOH 14  414 209 HOH HOH A . 
C 3 HOH 15  415 138 HOH HOH A . 
C 3 HOH 16  416 118 HOH HOH A . 
C 3 HOH 17  417 53  HOH HOH A . 
C 3 HOH 18  418 201 HOH HOH A . 
C 3 HOH 19  419 144 HOH HOH A . 
C 3 HOH 20  420 37  HOH HOH A . 
C 3 HOH 21  421 41  HOH HOH A . 
C 3 HOH 22  422 193 HOH HOH A . 
C 3 HOH 23  423 67  HOH HOH A . 
C 3 HOH 24  424 128 HOH HOH A . 
C 3 HOH 25  425 54  HOH HOH A . 
C 3 HOH 26  426 159 HOH HOH A . 
C 3 HOH 27  427 94  HOH HOH A . 
C 3 HOH 28  428 26  HOH HOH A . 
C 3 HOH 29  429 16  HOH HOH A . 
C 3 HOH 30  430 93  HOH HOH A . 
C 3 HOH 31  431 112 HOH HOH A . 
C 3 HOH 32  432 27  HOH HOH A . 
C 3 HOH 33  433 82  HOH HOH A . 
C 3 HOH 34  434 104 HOH HOH A . 
C 3 HOH 35  435 36  HOH HOH A . 
C 3 HOH 36  436 40  HOH HOH A . 
C 3 HOH 37  437 42  HOH HOH A . 
C 3 HOH 38  438 73  HOH HOH A . 
C 3 HOH 39  439 199 HOH HOH A . 
C 3 HOH 40  440 110 HOH HOH A . 
C 3 HOH 41  441 197 HOH HOH A . 
C 3 HOH 42  442 156 HOH HOH A . 
C 3 HOH 43  443 87  HOH HOH A . 
C 3 HOH 44  444 34  HOH HOH A . 
C 3 HOH 45  445 90  HOH HOH A . 
C 3 HOH 46  446 114 HOH HOH A . 
C 3 HOH 47  447 81  HOH HOH A . 
C 3 HOH 48  448 136 HOH HOH A . 
C 3 HOH 49  449 7   HOH HOH A . 
C 3 HOH 50  450 63  HOH HOH A . 
C 3 HOH 51  451 132 HOH HOH A . 
C 3 HOH 52  452 8   HOH HOH A . 
C 3 HOH 53  453 135 HOH HOH A . 
C 3 HOH 54  454 196 HOH HOH A . 
C 3 HOH 55  455 106 HOH HOH A . 
C 3 HOH 56  456 51  HOH HOH A . 
C 3 HOH 57  457 74  HOH HOH A . 
C 3 HOH 58  458 85  HOH HOH A . 
C 3 HOH 59  459 157 HOH HOH A . 
C 3 HOH 60  460 117 HOH HOH A . 
C 3 HOH 61  461 189 HOH HOH A . 
C 3 HOH 62  462 131 HOH HOH A . 
C 3 HOH 63  463 109 HOH HOH A . 
C 3 HOH 64  464 29  HOH HOH A . 
C 3 HOH 65  465 24  HOH HOH A . 
C 3 HOH 66  466 211 HOH HOH A . 
C 3 HOH 67  467 202 HOH HOH A . 
C 3 HOH 68  468 167 HOH HOH A . 
C 3 HOH 69  469 52  HOH HOH A . 
C 3 HOH 70  470 57  HOH HOH A . 
C 3 HOH 71  471 83  HOH HOH A . 
C 3 HOH 72  472 6   HOH HOH A . 
C 3 HOH 73  473 12  HOH HOH A . 
C 3 HOH 74  474 221 HOH HOH A . 
C 3 HOH 75  475 14  HOH HOH A . 
C 3 HOH 76  476 55  HOH HOH A . 
C 3 HOH 77  477 127 HOH HOH A . 
C 3 HOH 78  478 78  HOH HOH A . 
C 3 HOH 79  479 139 HOH HOH A . 
C 3 HOH 80  480 28  HOH HOH A . 
C 3 HOH 81  481 133 HOH HOH A . 
C 3 HOH 82  482 45  HOH HOH A . 
C 3 HOH 83  483 4   HOH HOH A . 
C 3 HOH 84  484 15  HOH HOH A . 
C 3 HOH 85  485 98  HOH HOH A . 
C 3 HOH 86  486 10  HOH HOH A . 
C 3 HOH 87  487 1   HOH HOH A . 
C 3 HOH 88  488 25  HOH HOH A . 
C 3 HOH 89  489 99  HOH HOH A . 
C 3 HOH 90  490 38  HOH HOH A . 
C 3 HOH 91  491 96  HOH HOH A . 
C 3 HOH 92  492 2   HOH HOH A . 
C 3 HOH 93  493 122 HOH HOH A . 
C 3 HOH 94  494 184 HOH HOH A . 
C 3 HOH 95  495 105 HOH HOH A . 
C 3 HOH 96  496 46  HOH HOH A . 
C 3 HOH 97  497 39  HOH HOH A . 
C 3 HOH 98  498 5   HOH HOH A . 
C 3 HOH 99  499 220 HOH HOH A . 
C 3 HOH 100 500 68  HOH HOH A . 
C 3 HOH 101 501 11  HOH HOH A . 
C 3 HOH 102 502 61  HOH HOH A . 
C 3 HOH 103 503 49  HOH HOH A . 
C 3 HOH 104 504 91  HOH HOH A . 
C 3 HOH 105 505 33  HOH HOH A . 
C 3 HOH 106 506 183 HOH HOH A . 
C 3 HOH 107 507 80  HOH HOH A . 
C 3 HOH 108 508 181 HOH HOH A . 
C 3 HOH 109 509 97  HOH HOH A . 
C 3 HOH 110 510 62  HOH HOH A . 
C 3 HOH 111 511 151 HOH HOH A . 
C 3 HOH 112 512 227 HOH HOH A . 
C 3 HOH 113 513 35  HOH HOH A . 
C 3 HOH 114 514 23  HOH HOH A . 
C 3 HOH 115 515 207 HOH HOH A . 
C 3 HOH 116 516 166 HOH HOH A . 
C 3 HOH 117 517 66  HOH HOH A . 
C 3 HOH 118 518 30  HOH HOH A . 
C 3 HOH 119 519 75  HOH HOH A . 
C 3 HOH 120 520 72  HOH HOH A . 
C 3 HOH 121 521 92  HOH HOH A . 
C 3 HOH 122 522 187 HOH HOH A . 
C 3 HOH 123 523 9   HOH HOH A . 
C 3 HOH 124 524 168 HOH HOH A . 
C 3 HOH 125 525 229 HOH HOH A . 
C 3 HOH 126 526 145 HOH HOH A . 
C 3 HOH 127 527 77  HOH HOH A . 
C 3 HOH 128 528 44  HOH HOH A . 
C 3 HOH 129 529 43  HOH HOH A . 
C 3 HOH 130 530 175 HOH HOH A . 
C 3 HOH 131 531 172 HOH HOH A . 
C 3 HOH 132 532 70  HOH HOH A . 
C 3 HOH 133 533 111 HOH HOH A . 
C 3 HOH 134 534 206 HOH HOH A . 
C 3 HOH 135 535 210 HOH HOH A . 
C 3 HOH 136 536 124 HOH HOH A . 
C 3 HOH 137 537 194 HOH HOH A . 
C 3 HOH 138 538 13  HOH HOH A . 
C 3 HOH 139 539 204 HOH HOH A . 
C 3 HOH 140 540 95  HOH HOH A . 
C 3 HOH 141 541 121 HOH HOH A . 
C 3 HOH 142 542 60  HOH HOH A . 
C 3 HOH 143 543 195 HOH HOH A . 
C 3 HOH 144 544 214 HOH HOH A . 
C 3 HOH 145 545 192 HOH HOH A . 
C 3 HOH 146 546 230 HOH HOH A . 
C 3 HOH 147 547 71  HOH HOH A . 
C 3 HOH 148 548 56  HOH HOH A . 
C 3 HOH 149 549 32  HOH HOH A . 
C 3 HOH 150 550 163 HOH HOH A . 
C 3 HOH 151 551 3   HOH HOH A . 
C 3 HOH 152 552 84  HOH HOH A . 
C 3 HOH 153 553 21  HOH HOH A . 
C 3 HOH 154 554 198 HOH HOH A . 
C 3 HOH 155 555 22  HOH HOH A . 
C 3 HOH 156 556 228 HOH HOH A . 
C 3 HOH 157 557 152 HOH HOH A . 
C 3 HOH 158 558 102 HOH HOH A . 
C 3 HOH 159 559 148 HOH HOH A . 
C 3 HOH 160 560 205 HOH HOH A . 
C 3 HOH 161 561 18  HOH HOH A . 
C 3 HOH 162 562 177 HOH HOH A . 
C 3 HOH 163 563 218 HOH HOH A . 
C 3 HOH 164 564 17  HOH HOH A . 
C 3 HOH 165 565 125 HOH HOH A . 
C 3 HOH 166 566 107 HOH HOH A . 
C 3 HOH 167 567 170 HOH HOH A . 
C 3 HOH 168 568 155 HOH HOH A . 
C 3 HOH 169 569 50  HOH HOH A . 
C 3 HOH 170 570 143 HOH HOH A . 
C 3 HOH 171 571 200 HOH HOH A . 
C 3 HOH 172 572 141 HOH HOH A . 
C 3 HOH 173 573 48  HOH HOH A . 
C 3 HOH 174 574 154 HOH HOH A . 
C 3 HOH 175 575 116 HOH HOH A . 
C 3 HOH 176 576 69  HOH HOH A . 
C 3 HOH 177 577 129 HOH HOH A . 
C 3 HOH 178 578 149 HOH HOH A . 
C 3 HOH 179 579 101 HOH HOH A . 
C 3 HOH 180 580 108 HOH HOH A . 
C 3 HOH 181 581 169 HOH HOH A . 
C 3 HOH 182 582 140 HOH HOH A . 
C 3 HOH 183 583 213 HOH HOH A . 
C 3 HOH 184 584 226 HOH HOH A . 
C 3 HOH 185 585 188 HOH HOH A . 
C 3 HOH 186 586 115 HOH HOH A . 
C 3 HOH 187 587 212 HOH HOH A . 
C 3 HOH 188 588 89  HOH HOH A . 
C 3 HOH 189 589 191 HOH HOH A . 
C 3 HOH 190 590 180 HOH HOH A . 
C 3 HOH 191 591 219 HOH HOH A . 
C 3 HOH 192 592 130 HOH HOH A . 
C 3 HOH 193 593 225 HOH HOH A . 
C 3 HOH 194 594 223 HOH HOH A . 
C 3 HOH 195 595 164 HOH HOH A . 
C 3 HOH 196 596 120 HOH HOH A . 
C 3 HOH 197 597 171 HOH HOH A . 
C 3 HOH 198 598 126 HOH HOH A . 
C 3 HOH 199 599 113 HOH HOH A . 
C 3 HOH 200 600 224 HOH HOH A . 
C 3 HOH 201 601 186 HOH HOH A . 
C 3 HOH 202 602 161 HOH HOH A . 
C 3 HOH 203 603 162 HOH HOH A . 
C 3 HOH 204 604 158 HOH HOH A . 
C 3 HOH 205 605 153 HOH HOH A . 
C 3 HOH 206 606 134 HOH HOH A . 
C 3 HOH 207 607 86  HOH HOH A . 
C 3 HOH 208 608 190 HOH HOH A . 
C 3 HOH 209 609 59  HOH HOH A . 
C 3 HOH 210 610 165 HOH HOH A . 
C 3 HOH 211 611 179 HOH HOH A . 
C 3 HOH 212 612 182 HOH HOH A . 
C 3 HOH 213 613 31  HOH HOH A . 
C 3 HOH 214 614 176 HOH HOH A . 
C 3 HOH 215 615 185 HOH HOH A . 
C 3 HOH 216 616 123 HOH HOH A . 
C 3 HOH 217 617 79  HOH HOH A . 
C 3 HOH 218 618 119 HOH HOH A . 
C 3 HOH 219 619 142 HOH HOH A . 
C 3 HOH 220 620 88  HOH HOH A . 
C 3 HOH 221 621 216 HOH HOH A . 
C 3 HOH 222 622 222 HOH HOH A . 
C 3 HOH 223 623 217 HOH HOH A . 
C 3 HOH 224 624 146 HOH HOH A . 
C 3 HOH 225 625 147 HOH HOH A . 
C 3 HOH 226 626 215 HOH HOH A . 
D 3 HOH 1   101 47  HOH HOH B . 
D 3 HOH 2   102 203 HOH HOH B . 
D 3 HOH 3   103 150 HOH HOH B . 
D 3 HOH 4   104 160 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A TYR 35 ? CG  ? A TYR 35 CG  
2 1 Y 1 A TYR 35 ? CD1 ? A TYR 35 CD1 
3 1 Y 1 A TYR 35 ? CD2 ? A TYR 35 CD2 
4 1 Y 1 A TYR 35 ? CE1 ? A TYR 35 CE1 
5 1 Y 1 A TYR 35 ? CE2 ? A TYR 35 CE2 
6 1 Y 1 A TYR 35 ? CZ  ? A TYR 35 CZ  
7 1 Y 1 A TYR 35 ? OH  ? A TYR 35 OH  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YPF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     81.873 
_cell.length_a_esd                 ? 
_cell.length_b                     81.873 
_cell.length_b_esd                 ? 
_cell.length_c                     122.585 
_cell.length_c_esd                 ? 
_cell.volume                       711622.023 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YPF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YPF 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.81 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.27 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;25% PEG1500, 
0.1 M MMT buffer (DL-malic acid, MES monohydrate and Tris base, molar ratios 1:2:2) pH 7.0
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-05-05 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.975 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL17U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.975 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL17U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          23.88 
_reflns.entry_id                                       8YPF 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     32662 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          34.24 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.00 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.04 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.07 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.36 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3201 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.70 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.87 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.77 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YPF 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             40.94 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     31847 
_refine.ls_number_reflns_R_free                  1535 
_refine.ls_number_reflns_R_work                  30312 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.33 
_refine.ls_percent_reflns_R_free                 4.82 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1921 
_refine.ls_R_factor_R_free                       0.2181 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1907 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.9915 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2293 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        40.94 
_refine_hist.number_atoms_solvent             230 
_refine_hist.number_atoms_total               2991 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2761 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0078  ? 2824 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8931  ? 3829 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0553  ? 430  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0079  ? 489  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.1079 ? 1049 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.07  . . 94  2110 75.25  . . . . 0.2471 . . . . . . . . . . . 0.3272 
'X-RAY DIFFRACTION' 2.07 2.14  . . 143 2701 97.50  . . . . 0.2376 . . . . . . . . . . . 0.2448 
'X-RAY DIFFRACTION' 2.14 2.22  . . 181 2746 99.56  . . . . 0.2175 . . . . . . . . . . . 0.2639 
'X-RAY DIFFRACTION' 2.22 2.33  . . 150 2804 99.86  . . . . 0.2145 . . . . . . . . . . . 0.2579 
'X-RAY DIFFRACTION' 2.33 2.45  . . 138 2772 99.93  . . . . 0.2131 . . . . . . . . . . . 0.2545 
'X-RAY DIFFRACTION' 2.45 2.60  . . 93  2850 99.97  . . . . 0.2184 . . . . . . . . . . . 0.2361 
'X-RAY DIFFRACTION' 2.60 2.80  . . 149 2832 100.00 . . . . 0.1949 . . . . . . . . . . . 0.2196 
'X-RAY DIFFRACTION' 2.80 3.08  . . 125 2835 99.73  . . . . 0.2086 . . . . . . . . . . . 0.2352 
'X-RAY DIFFRACTION' 3.08 3.53  . . 149 2843 99.97  . . . . 0.1911 . . . . . . . . . . . 0.2121 
'X-RAY DIFFRACTION' 3.53 4.45  . . 177 2836 99.77  . . . . 0.1572 . . . . . . . . . . . 0.1935 
'X-RAY DIFFRACTION' 4.45 40.94 . . 136 2983 98.83  . . . . 0.1635 . . . . . . . . . . . 0.1793 
# 
_struct.entry_id                     8YPF 
_struct.title                        'The crystal structure of inactive p38 complexed with a ATF2 from 46 to 90' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YPF 
_struct_keywords.text            'MAP KINASE P38 ALPHA, docking interactions, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP MK14_MOUSE P47811 ? 1 
;MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH
ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA
DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
1  
2 UNP ATF2_HUMAN P15336 ? 2 KHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS 46 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YPF A 1 ? 360 ? P47811 1  ? 360 ? 1  360 
2 2 8YPF B 1 ? 45  ? P15336 46 ? 90  ? 46 90  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 900   ? 
1 MORE         -6    ? 
1 'SSA (A^2)'  17190 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 61  ? MET A 78  ? SER A 61  MET A 78  1 ? 18 
HELX_P HELX_P2  AA2 LEU A 113 ? CYS A 119 ? LEU A 113 CYS A 119 1 ? 7  
HELX_P HELX_P3  AA3 THR A 123 ? ALA A 144 ? THR A 123 ALA A 144 1 ? 22 
HELX_P HELX_P4  AA4 LYS A 152 ? SER A 154 ? LYS A 152 SER A 154 5 ? 3  
HELX_P HELX_P5  AA5 THR A 185 ? ARG A 189 ? THR A 185 ARG A 189 5 ? 5  
HELX_P HELX_P6  AA6 ALA A 190 ? LEU A 195 ? ALA A 190 LEU A 195 1 ? 6  
HELX_P HELX_P7  AA7 THR A 203 ? GLY A 219 ? THR A 203 GLY A 219 1 ? 17 
HELX_P HELX_P8  AA8 ASP A 227 ? GLY A 240 ? ASP A 227 GLY A 240 1 ? 14 
HELX_P HELX_P9  AA9 GLY A 243 ? LYS A 248 ? GLY A 243 LYS A 248 1 ? 6  
HELX_P HELX_P10 AB1 SER A 252 ? LEU A 262 ? SER A 252 LEU A 262 1 ? 11 
HELX_P HELX_P11 AB2 ASN A 269 ? VAL A 273 ? ASN A 269 VAL A 273 5 ? 5  
HELX_P HELX_P12 AB3 ASN A 278 ? LEU A 289 ? ASN A 278 LEU A 289 1 ? 12 
HELX_P HELX_P13 AB4 ASP A 292 ? ARG A 296 ? ASP A 292 ARG A 296 5 ? 5  
HELX_P HELX_P14 AB5 THR A 298 ? ALA A 304 ? THR A 298 ALA A 304 1 ? 7  
HELX_P HELX_P15 AB6 HIS A 305 ? ALA A 309 ? HIS A 305 ALA A 309 5 ? 5  
HELX_P HELX_P16 AB7 GLN A 325 ? ARG A 330 ? GLN A 325 ARG A 330 5 ? 6  
HELX_P HELX_P17 AB8 LEU A 333 ? SER A 347 ? LEU A 333 SER A 347 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 8   ? LEU A 13  ? PHE A 8   LEU A 13  
AA1 2 THR A 16  ? PRO A 21  ? THR A 16  PRO A 21  
AA2 1 TYR A 24  ? GLY A 31  ? TYR A 24  GLY A 31  
AA2 2 GLY A 36  ? ASP A 43  ? GLY A 36  ASP A 43  
AA2 3 HIS A 48  ? LEU A 55  ? HIS A 48  LEU A 55  
AA2 4 TYR A 103 ? HIS A 107 ? TYR A 103 HIS A 107 
AA2 5 ASP A 88  ? PHE A 90  ? ASP A 88  PHE A 90  
AA3 1 ALA A 111 ? ASP A 112 ? ALA A 111 ASP A 112 
AA3 2 LEU A 156 ? VAL A 158 ? LEU A 156 VAL A 158 
AA3 3 LEU A 164 ? ILE A 166 ? LEU A 164 ILE A 166 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 11  ? N GLN A 11  O TRP A 18  ? O TRP A 18  
AA2 1 2 N GLN A 25  ? N GLN A 25  O PHE A 42  ? O PHE A 42  
AA2 2 3 N CYS A 39  ? N CYS A 39  O VAL A 52  ? O VAL A 52  
AA2 3 4 N LYS A 53  ? N LYS A 53  O LEU A 104 ? O LEU A 104 
AA2 4 5 O VAL A 105 ? O VAL A 105 N ASP A 88  ? N ASP A 88  
AA3 1 2 N ALA A 111 ? N ALA A 111 O VAL A 158 ? O VAL A 158 
AA3 2 3 N ALA A 157 ? N ALA A 157 O LYS A 165 ? O LYS A 165 
# 
_pdbx_entry_details.entry_id                   8YPF 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 149 ? ? 76.29   -10.55 
2 1 ASP A 150 ? ? -140.80 41.83  
3 1 ASP A 168 ? ? 61.80   65.14  
4 1 LEU A 289 ? ? -97.81  51.38  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 625 ? 5.84 . 
2 1 O ? A HOH 626 ? 6.00 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A SER 2   ? A SER 2   
3  1 Y 1 A GLN 3   ? A GLN 3   
4  1 Y 1 A GLU 4   ? A GLU 4   
5  1 Y 1 A LEU 171 ? A LEU 171 
6  1 Y 1 A ALA 172 ? A ALA 172 
7  1 Y 1 A ARG 173 ? A ARG 173 
8  1 Y 1 A HIS 174 ? A HIS 174 
9  1 Y 1 A THR 175 ? A THR 175 
10 1 Y 1 A ASP 176 ? A ASP 176 
11 1 Y 1 A ASP 177 ? A ASP 177 
12 1 Y 1 A GLU 178 ? A GLU 178 
13 1 Y 1 A MET 179 ? A MET 179 
14 1 Y 1 A THR 180 ? A THR 180 
15 1 Y 1 A GLY 181 ? A GLY 181 
16 1 Y 1 A TYR 182 ? A TYR 182 
17 1 Y 1 A VAL 183 ? A VAL 183 
18 1 Y 1 A ASP 354 ? A ASP 354 
19 1 Y 1 A GLN 355 ? A GLN 355 
20 1 Y 1 A GLU 356 ? A GLU 356 
21 1 Y 1 A GLU 357 ? A GLU 357 
22 1 Y 1 A MET 358 ? A MET 358 
23 1 Y 1 A GLU 359 ? A GLU 359 
24 1 Y 1 A SER 360 ? A SER 360 
25 1 Y 1 B LYS 46  ? B LYS 1   
26 1 Y 1 B HIS 47  ? B HIS 2   
27 1 Y 1 B LYS 48  ? B LYS 3   
28 1 Y 1 B HIS 49  ? B HIS 4   
29 1 Y 1 B PRO 57  ? B PRO 12  
30 1 Y 1 B ALA 58  ? B ALA 13  
31 1 Y 1 B ARG 59  ? B ARG 14  
32 1 Y 1 B ASN 60  ? B ASN 15  
33 1 Y 1 B ASP 61  ? B ASP 16  
34 1 Y 1 B SER 62  ? B SER 17  
35 1 Y 1 B VAL 63  ? B VAL 18  
36 1 Y 1 B ILE 64  ? B ILE 19  
37 1 Y 1 B VAL 65  ? B VAL 20  
38 1 Y 1 B ALA 66  ? B ALA 21  
39 1 Y 1 B ASP 67  ? B ASP 22  
40 1 Y 1 B GLN 68  ? B GLN 23  
41 1 Y 1 B THR 69  ? B THR 24  
42 1 Y 1 B PRO 70  ? B PRO 25  
43 1 Y 1 B THR 71  ? B THR 26  
44 1 Y 1 B PRO 72  ? B PRO 27  
45 1 Y 1 B THR 73  ? B THR 28  
46 1 Y 1 B ARG 74  ? B ARG 29  
47 1 Y 1 B PHE 75  ? B PHE 30  
48 1 Y 1 B LEU 76  ? B LEU 31  
49 1 Y 1 B LYS 77  ? B LYS 32  
50 1 Y 1 B ASN 78  ? B ASN 33  
51 1 Y 1 B CYS 79  ? B CYS 34  
52 1 Y 1 B GLU 80  ? B GLU 35  
53 1 Y 1 B GLU 81  ? B GLU 36  
54 1 Y 1 B VAL 82  ? B VAL 37  
55 1 Y 1 B GLY 83  ? B GLY 38  
56 1 Y 1 B LEU 84  ? B LEU 39  
57 1 Y 1 B PHE 85  ? B PHE 40  
58 1 Y 1 B ASN 86  ? B ASN 41  
59 1 Y 1 B GLU 87  ? B GLU 42  
60 1 Y 1 B LEU 88  ? B LEU 43  
61 1 Y 1 B ALA 89  ? B ALA 44  
62 1 Y 1 B SER 90  ? B SER 45  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministry of Science and Technology (MoST, China)' China 2019YFA0802500 1 
'Ministry of Science and Technology (MoST, China)' China 2022YFA0806504 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1P38 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YPF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012214 
_atom_sites.fract_transf_matrix[1][2]   0.007052 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014104 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008158 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ARG A 1 5   ? -22.20178 52.77834 0.29727   1.000 33.54879  ? 5   ARG A N   1 
ATOM   2    C CA  . ARG A 1 5   ? -22.89567 53.11689 -0.94680  1.000 35.56879  ? 5   ARG A CA  1 
ATOM   3    C C   . ARG A 1 5   ? -21.93258 53.60670 -2.02987  1.000 37.48879  ? 5   ARG A C   1 
ATOM   4    O O   . ARG A 1 5   ? -21.23350 54.60542 -1.85065  1.000 41.31879  ? 5   ARG A O   1 
ATOM   5    C CB  . ARG A 1 5   ? -23.97054 54.18123 -0.71659  1.000 33.99879  ? 5   ARG A CB  1 
ATOM   6    C CG  . ARG A 1 5   ? -24.82346 54.44086 -1.96102  1.000 37.36879  ? 5   ARG A CG  1 
ATOM   7    C CD  . ARG A 1 5   ? -25.83889 55.55608 -1.75657  1.000 33.11879  ? 5   ARG A CD  1 
ATOM   8    N NE  . ARG A 1 5   ? -26.73052 55.75116 -2.89654  1.000 30.34879  ? 5   ARG A NE  1 
ATOM   9    C CZ  . ARG A 1 5   ? -26.49486 56.56886 -3.91612  1.000 31.71879  ? 5   ARG A CZ  1 
ATOM   10   N NH1 . ARG A 1 5   ? -25.35009 57.22320 -4.03213  1.000 38.09879  ? 5   ARG A NH1 1 
ATOM   11   N NH2 . ARG A 1 5   ? -27.43318 56.73446 -4.84453  1.000 35.02879  ? 5   ARG A NH2 1 
ATOM   12   N N   . PRO A 1 6   ? -21.90900 52.91369 -3.16376  1.000 36.64617  ? 6   PRO A N   1 
ATOM   13   C CA  . PRO A 1 6   ? -21.04497 53.33592 -4.26964  1.000 31.30617  ? 6   PRO A CA  1 
ATOM   14   C C   . PRO A 1 6   ? -21.52994 54.63602 -4.89124  1.000 25.62617  ? 6   PRO A C   1 
ATOM   15   O O   . PRO A 1 6   ? -22.63397 55.12099 -4.63253  1.000 21.22617  ? 6   PRO A O   1 
ATOM   16   C CB  . PRO A 1 6   ? -21.15682 52.17723 -5.26121  1.000 35.50617  ? 6   PRO A CB  1 
ATOM   17   C CG  . PRO A 1 6   ? -22.50789 51.62520 -5.01381  1.000 36.72617  ? 6   PRO A CG  1 
ATOM   18   C CD  . PRO A 1 6   ? -22.71224 51.72937 -3.51745  1.000 36.53617  ? 6   PRO A CD  1 
ATOM   19   N N   . THR A 1 7   ? -20.66959 55.20369 -5.73166  1.000 23.26961  ? 7   THR A N   1 
ATOM   20   C CA  . THR A 1 7   ? -21.05214 56.33020 -6.56889  1.000 24.98961  ? 7   THR A CA  1 
ATOM   21   C C   . THR A 1 7   ? -21.80153 55.82276 -7.78714  1.000 22.50961  ? 7   THR A C   1 
ATOM   22   O O   . THR A 1 7   ? -21.32335 54.92348 -8.48871  1.000 24.44961  ? 7   THR A O   1 
ATOM   23   C CB  . THR A 1 7   ? -19.81870 57.12414 -7.00479  1.000 26.87961  ? 7   THR A CB  1 
ATOM   24   O OG1 . THR A 1 7   ? -19.22423 57.73205 -5.85845  1.000 30.02961  ? 7   THR A OG1 1 
ATOM   25   C CG2 . THR A 1 7   ? -20.19263 58.20386 -8.00215  1.000 28.62961  ? 7   THR A CG2 1 
ATOM   26   N N   . PHE A 1 8   ? -22.97826 56.38997 -8.03253  1.000 20.02422  ? 8   PHE A N   1 
ATOM   27   C CA  . PHE A 1 8   ? -23.78723 56.05492 -9.19126  1.000 21.52422  ? 8   PHE A CA  1 
ATOM   28   C C   . PHE A 1 8   ? -23.57070 57.07367 -10.30174 1.000 24.20422  ? 8   PHE A C   1 
ATOM   29   O O   . PHE A 1 8   ? -23.24535 58.23656 -10.05168 1.000 27.78422  ? 8   PHE A O   1 
ATOM   30   C CB  . PHE A 1 8   ? -25.27370 56.01832 -8.82323  1.000 21.95422  ? 8   PHE A CB  1 
ATOM   31   C CG  . PHE A 1 8   ? -25.68681 54.79093 -8.04963  1.000 20.64422  ? 8   PHE A CG  1 
ATOM   32   C CD1 . PHE A 1 8   ? -25.28628 54.60977 -6.73254  1.000 20.66422  ? 8   PHE A CD1 1 
ATOM   33   C CD2 . PHE A 1 8   ? -26.49795 53.82704 -8.63537  1.000 20.00422  ? 8   PHE A CD2 1 
ATOM   34   C CE1 . PHE A 1 8   ? -25.66787 53.47479 -6.01811  1.000 20.21422  ? 8   PHE A CE1 1 
ATOM   35   C CE2 . PHE A 1 8   ? -26.89548 52.69571 -7.91525  1.000 17.86422  ? 8   PHE A CE2 1 
ATOM   36   C CZ  . PHE A 1 8   ? -26.47110 52.51373 -6.62528  1.000 19.43422  ? 8   PHE A CZ  1 
ATOM   37   N N   . TYR A 1 9   ? -23.76735 56.63669 -11.53193 1.000 22.97330  ? 9   TYR A N   1 
ATOM   38   C CA  . TYR A 1 9   ? -23.84539 57.55729 -12.64702 1.000 24.64330  ? 9   TYR A CA  1 
ATOM   39   C C   . TYR A 1 9   ? -25.07344 57.21080 -13.46384 1.000 26.29330  ? 9   TYR A C   1 
ATOM   40   O O   . TYR A 1 9   ? -25.53546 56.06811 -13.47662 1.000 29.39330  ? 9   TYR A O   1 
ATOM   41   C CB  . TYR A 1 9   ? -22.57126 57.55567 -13.52786 1.000 22.96330  ? 9   TYR A CB  1 
ATOM   42   C CG  . TYR A 1 9   ? -22.28290 56.29093 -14.32274 1.000 20.65330  ? 9   TYR A CG  1 
ATOM   43   C CD1 . TYR A 1 9   ? -21.82326 55.12479 -13.69783 1.000 20.44330  ? 9   TYR A CD1 1 
ATOM   44   C CD2 . TYR A 1 9   ? -22.41885 56.28106 -15.70097 1.000 22.65330  ? 9   TYR A CD2 1 
ATOM   45   C CE1 . TYR A 1 9   ? -21.54145 53.97215 -14.44414 1.000 19.38330  ? 9   TYR A CE1 1 
ATOM   46   C CE2 . TYR A 1 9   ? -22.14747 55.15655 -16.44134 1.000 19.86330  ? 9   TYR A CE2 1 
ATOM   47   C CZ  . TYR A 1 9   ? -21.70226 54.00711 -15.81775 1.000 19.90330  ? 9   TYR A CZ  1 
ATOM   48   O OH  . TYR A 1 9   ? -21.43056 52.89599 -16.60115 1.000 22.99330  ? 9   TYR A OH  1 
ATOM   49   N N   . ARG A 1 10  ? -25.59588 58.22230 -14.13566 1.000 25.59279  ? 10  ARG A N   1 
ATOM   50   C CA  . ARG A 1 10  ? -26.89998 58.18283 -14.77141 1.000 30.91279  ? 10  ARG A CA  1 
ATOM   51   C C   . ARG A 1 10  ? -26.72130 58.35605 -16.26736 1.000 33.93279  ? 10  ARG A C   1 
ATOM   52   O O   . ARG A 1 10  ? -25.94658 59.20952 -16.70740 1.000 38.23279  ? 10  ARG A O   1 
ATOM   53   C CB  . ARG A 1 10  ? -27.78779 59.29520 -14.19790 1.000 35.32279  ? 10  ARG A CB  1 
ATOM   54   C CG  . ARG A 1 10  ? -29.25275 59.18476 -14.51529 1.000 42.48279  ? 10  ARG A CG  1 
ATOM   55   C CD  . ARG A 1 10  ? -30.00756 60.33059 -13.88396 1.000 47.45279  ? 10  ARG A CD  1 
ATOM   56   N NE  . ARG A 1 10  ? -31.42649 60.26898 -14.20232 1.000 58.06279  ? 10  ARG A NE  1 
ATOM   57   C CZ  . ARG A 1 10  ? -32.26394 61.28735 -14.07733 1.000 67.25279  ? 10  ARG A CZ  1 
ATOM   58   N NH1 . ARG A 1 10  ? -31.85336 62.47042 -13.64854 1.000 73.35279  ? 10  ARG A NH1 1 
ATOM   59   N NH2 . ARG A 1 10  ? -33.54420 61.11557 -14.39479 1.000 70.29279  ? 10  ARG A NH2 1 
ATOM   60   N N   . GLN A 1 11  ? -27.42201 57.54270 -17.05001 1.000 30.13249  ? 11  GLN A N   1 
ATOM   61   C CA  . GLN A 1 11  ? -27.35676 57.68060 -18.49657 1.000 36.65249  ? 11  GLN A CA  1 
ATOM   62   C C   . GLN A 1 11  ? -28.66004 57.19604 -19.10833 1.000 39.45249  ? 11  GLN A C   1 
ATOM   63   O O   . GLN A 1 11  ? -29.42643 56.45478 -18.48349 1.000 36.60249  ? 11  GLN A O   1 
ATOM   64   C CB  . GLN A 1 11  ? -26.18706 56.89654 -19.08108 1.000 36.89249  ? 11  GLN A CB  1 
ATOM   65   C CG  . GLN A 1 11  ? -26.30418 55.41828 -18.86944 1.000 36.39249  ? 11  GLN A CG  1 
ATOM   66   C CD  . GLN A 1 11  ? -25.06332 54.69662 -19.32054 1.000 42.73249  ? 11  GLN A CD  1 
ATOM   67   O OE1 . GLN A 1 11  ? -24.60038 54.89865 -20.44183 1.000 52.11249  ? 11  GLN A OE1 1 
ATOM   68   N NE2 . GLN A 1 11  ? -24.50086 53.86325 -18.44661 1.000 38.84249  ? 11  GLN A NE2 1 
ATOM   69   N N   . GLU A 1 12  ? -28.90584 57.62093 -20.34413 1.000 41.23861  ? 12  GLU A N   1 
ATOM   70   C CA  . GLU A 1 12  ? -30.05975 57.16121 -21.10525 1.000 42.59861  ? 12  GLU A CA  1 
ATOM   71   C C   . GLU A 1 12  ? -29.56588 56.30548 -22.26116 1.000 40.82861  ? 12  GLU A C   1 
ATOM   72   O O   . GLU A 1 12  ? -28.78071 56.77533 -23.08947 1.000 42.86861  ? 12  GLU A O   1 
ATOM   73   C CB  . GLU A 1 12  ? -30.89918 58.33241 -21.61641 1.000 47.67861  ? 12  GLU A CB  1 
ATOM   74   C CG  . GLU A 1 12  ? -32.27415 57.90878 -22.11391 1.000 51.03861  ? 12  GLU A CG  1 
ATOM   75   C CD  . GLU A 1 12  ? -33.05412 59.03914 -22.76601 1.000 61.33861  ? 12  GLU A CD  1 
ATOM   76   O OE1 . GLU A 1 12  ? -32.59990 59.56050 -23.80761 1.000 68.34861  ? 12  GLU A OE1 1 
ATOM   77   O OE2 . GLU A 1 12  ? -34.12632 59.40555 -22.23669 1.000 63.86861  ? 12  GLU A OE2 1 
ATOM   78   N N   . LEU A 1 13  ? -30.01745 55.05361 -22.30560 1.000 38.71484  ? 13  LEU A N   1 
ATOM   79   C CA  . LEU A 1 13  ? -29.68909 54.12200 -23.37639 1.000 39.99484  ? 13  LEU A CA  1 
ATOM   80   C C   . LEU A 1 13  ? -30.98431 53.50230 -23.87218 1.000 48.16484  ? 13  LEU A C   1 
ATOM   81   O O   . LEU A 1 13  ? -31.70916 52.88720 -23.08226 1.000 49.28484  ? 13  LEU A O   1 
ATOM   82   C CB  . LEU A 1 13  ? -28.73561 53.02713 -22.89140 1.000 47.72484  ? 13  LEU A CB  1 
ATOM   83   C CG  . LEU A 1 13  ? -27.40799 53.44199 -22.26024 1.000 49.20484  ? 13  LEU A CG  1 
ATOM   84   C CD1 . LEU A 1 13  ? -26.70806 52.21779 -21.66717 1.000 47.45484  ? 13  LEU A CD1 1 
ATOM   85   C CD2 . LEU A 1 13  ? -26.51907 54.14967 -23.28531 1.000 47.89484  ? 13  LEU A CD2 1 
ATOM   86   N N   . ASN A 1 14  ? -31.26039 53.65309 -25.17748 1.000 55.03814  ? 14  ASN A N   1 
ATOM   87   C CA  . ASN A 1 14  ? -32.50996 53.19675 -25.81056 1.000 51.54814  ? 14  ASN A CA  1 
ATOM   88   C C   . ASN A 1 14  ? -33.73655 53.79220 -25.12317 1.000 44.07814  ? 14  ASN A C   1 
ATOM   89   O O   . ASN A 1 14  ? -34.73223 53.10203 -24.89796 1.000 47.08814  ? 14  ASN A O   1 
ATOM   90   C CB  . ASN A 1 14  ? -32.60985 51.66619 -25.84472 1.000 57.25814  ? 14  ASN A CB  1 
ATOM   91   C CG  . ASN A 1 14  ? -31.68679 51.03776 -26.86534 1.000 70.49814  ? 14  ASN A CG  1 
ATOM   92   O OD1 . ASN A 1 14  ? -30.81457 51.70231 -27.42795 1.000 84.40814  ? 14  ASN A OD1 1 
ATOM   93   N ND2 . ASN A 1 14  ? -31.87232 49.74251 -27.10865 1.000 75.91814  ? 14  ASN A ND2 1 
ATOM   94   N N   . LYS A 1 15  ? -33.64325 55.07738 -24.76807 1.000 43.89179  ? 15  LYS A N   1 
ATOM   95   C CA  . LYS A 1 15  ? -34.67727 55.81538 -24.03191 1.000 53.93179  ? 15  LYS A CA  1 
ATOM   96   C C   . LYS A 1 15  ? -35.07947 55.12469 -22.72348 1.000 56.03179  ? 15  LYS A C   1 
ATOM   97   O O   . LYS A 1 15  ? -36.22051 55.24797 -22.26853 1.000 56.34179  ? 15  LYS A O   1 
ATOM   98   C CB  . LYS A 1 15  ? -35.90478 56.08440 -24.90977 1.000 65.82179  ? 15  LYS A CB  1 
ATOM   99   C CG  . LYS A 1 15  ? -35.68011 57.19488 -25.93896 1.000 68.14179  ? 15  LYS A CG  1 
ATOM   100  C CD  . LYS A 1 15  ? -36.87083 57.35979 -26.87259 1.000 73.12179  ? 15  LYS A CD  1 
ATOM   101  C CE  . LYS A 1 15  ? -38.08176 57.94198 -26.15471 1.000 73.53179  ? 15  LYS A CE  1 
ATOM   102  N NZ  . LYS A 1 15  ? -39.25176 58.05710 -27.07471 1.000 73.82179  ? 15  LYS A NZ  1 
ATOM   103  N N   . THR A 1 16  ? -34.14379 54.39757 -22.11334 1.000 53.56956  ? 16  THR A N   1 
ATOM   104  C CA  . THR A 1 16  ? -34.28095 53.85407 -20.76803 1.000 46.66956  ? 16  THR A CA  1 
ATOM   105  C C   . THR A 1 16  ? -33.21780 54.50565 -19.89451 1.000 36.88956  ? 16  THR A C   1 
ATOM   106  O O   . THR A 1 16  ? -32.04715 54.56596 -20.28659 1.000 38.40956  ? 16  THR A O   1 
ATOM   107  C CB  . THR A 1 16  ? -34.10522 52.32919 -20.76250 1.000 53.55956  ? 16  THR A CB  1 
ATOM   108  O OG1 . THR A 1 16  ? -34.99683 51.72732 -21.70955 1.000 58.10956  ? 16  THR A OG1 1 
ATOM   109  C CG2 . THR A 1 16  ? -34.38323 51.75270 -19.37877 1.000 55.04956  ? 16  THR A CG2 1 
ATOM   110  N N   . ILE A 1 17  ? -33.61369 55.00634 -18.72875 1.000 35.78244  ? 17  ILE A N   1 
ATOM   111  C CA  . ILE A 1 17  ? -32.64038 55.55463 -17.78900 1.000 37.12244  ? 17  ILE A CA  1 
ATOM   112  C C   . ILE A 1 17  ? -31.98228 54.40875 -17.03001 1.000 32.35244  ? 17  ILE A C   1 
ATOM   113  O O   . ILE A 1 17  ? -32.66322 53.53340 -16.47977 1.000 39.58244  ? 17  ILE A O   1 
ATOM   114  C CB  . ILE A 1 17  ? -33.30279 56.54882 -16.82534 1.000 38.90244  ? 17  ILE A CB  1 
ATOM   115  C CG1 . ILE A 1 17  ? -33.98977 57.66938 -17.60781 1.000 41.98244  ? 17  ILE A CG1 1 
ATOM   116  C CG2 . ILE A 1 17  ? -32.27009 57.13241 -15.88380 1.000 36.96244  ? 17  ILE A CG2 1 
ATOM   117  C CD1 . ILE A 1 17  ? -33.02961 58.59348 -18.32152 1.000 46.23244  ? 17  ILE A CD1 1 
ATOM   118  N N   . TRP A 1 18  ? -30.65533 54.39826 -17.01521 1.000 31.06520  ? 18  TRP A N   1 
ATOM   119  C CA  . TRP A 1 18  ? -29.88092 53.44305 -16.23606 1.000 27.14520  ? 18  TRP A CA  1 
ATOM   120  C C   . TRP A 1 18  ? -29.04591 54.23099 -15.24316 1.000 25.07520  ? 18  TRP A C   1 
ATOM   121  O O   . TRP A 1 18  ? -28.25046 55.08737 -15.64382 1.000 25.17520  ? 18  TRP A O   1 
ATOM   122  C CB  . TRP A 1 18  ? -28.98673 52.58396 -17.13526 1.000 29.47520  ? 18  TRP A CB  1 
ATOM   123  C CG  . TRP A 1 18  ? -29.74620 51.59966 -17.97215 1.000 31.31520  ? 18  TRP A CG  1 
ATOM   124  C CD1 . TRP A 1 18  ? -30.50190 51.87444 -19.07724 1.000 36.17520  ? 18  TRP A CD1 1 
ATOM   125  C CD2 . TRP A 1 18  ? -29.82369 50.17945 -17.77849 1.000 27.63520  ? 18  TRP A CD2 1 
ATOM   126  N NE1 . TRP A 1 18  ? -31.04616 50.71533 -19.57997 1.000 35.62520  ? 18  TRP A NE1 1 
ATOM   127  C CE2 . TRP A 1 18  ? -30.64369 49.66133 -18.80212 1.000 35.52520  ? 18  TRP A CE2 1 
ATOM   128  C CE3 . TRP A 1 18  ? -29.28162 49.29788 -16.83852 1.000 27.43520  ? 18  TRP A CE3 1 
ATOM   129  C CZ2 . TRP A 1 18  ? -30.93766 48.30032 -18.90740 1.000 35.12520  ? 18  TRP A CZ2 1 
ATOM   130  C CZ3 . TRP A 1 18  ? -29.56003 47.95527 -16.94900 1.000 25.46520  ? 18  TRP A CZ3 1 
ATOM   131  C CH2 . TRP A 1 18  ? -30.38643 47.46455 -17.97460 1.000 32.28520  ? 18  TRP A CH2 1 
ATOM   132  N N   . GLU A 1 19  ? -29.24304 53.96908 -13.95739 1.000 21.73252  ? 19  GLU A N   1 
ATOM   133  C CA  . GLU A 1 19  ? -28.45522 54.60115 -12.90532 1.000 21.42252  ? 19  GLU A CA  1 
ATOM   134  C C   . GLU A 1 19  ? -27.81071 53.46867 -12.10967 1.000 19.84252  ? 19  GLU A C   1 
ATOM   135  O O   . GLU A 1 19  ? -28.48258 52.78907 -11.32500 1.000 18.96252  ? 19  GLU A O   1 
ATOM   136  C CB  . GLU A 1 19  ? -29.31170 55.53587 -12.03666 1.000 24.08252  ? 19  GLU A CB  1 
ATOM   137  C CG  . GLU A 1 19  ? -28.50245 56.34240 -11.00702 1.000 32.27252  ? 19  GLU A CG  1 
ATOM   138  C CD  . GLU A 1 19  ? -29.24428 57.56664 -10.43895 1.000 41.39252  ? 19  GLU A CD  1 
ATOM   139  O OE1 . GLU A 1 19  ? -30.40670 57.82136 -10.84081 1.000 44.64252  ? 19  GLU A OE1 1 
ATOM   140  O OE2 . GLU A 1 19  ? -28.65436 58.27963 -9.58673  1.000 41.27252  ? 19  GLU A OE2 1 
ATOM   141  N N   . VAL A 1 20  ? -26.51538 53.24503 -12.34493 1.000 20.48178  ? 20  VAL A N   1 
ATOM   142  C CA  . VAL A 1 20  ? -25.79346 52.08616 -11.82054 1.000 17.62178  ? 20  VAL A CA  1 
ATOM   143  C C   . VAL A 1 20  ? -24.51052 52.57015 -11.15082 1.000 17.20178  ? 20  VAL A C   1 
ATOM   144  O O   . VAL A 1 20  ? -24.02107 53.68030 -11.43926 1.000 17.80178  ? 20  VAL A O   1 
ATOM   145  C CB  . VAL A 1 20  ? -25.49070 51.04614 -12.93450 1.000 16.19178  ? 20  VAL A CB  1 
ATOM   146  C CG1 . VAL A 1 20  ? -26.76086 50.66232 -13.68508 1.000 17.39178  ? 20  VAL A CG1 1 
ATOM   147  C CG2 . VAL A 1 20  ? -24.40431 51.55417 -13.90281 1.000 16.01178  ? 20  VAL A CG2 1 
ATOM   148  N N   . PRO A 1 21  ? -23.94492 51.76833 -10.23425 1.000 16.85943  ? 21  PRO A N   1 
ATOM   149  C CA  . PRO A 1 21  ? -22.63255 52.10606 -9.66221  1.000 17.56943  ? 21  PRO A CA  1 
ATOM   150  C C   . PRO A 1 21  ? -21.53223 52.21538 -10.71372 1.000 19.41943  ? 21  PRO A C   1 
ATOM   151  O O   . PRO A 1 21  ? -21.58512 51.59594 -11.78239 1.000 17.94943  ? 21  PRO A O   1 
ATOM   152  C CB  . PRO A 1 21  ? -22.35068 50.94230 -8.70734  1.000 16.46943  ? 21  PRO A CB  1 
ATOM   153  C CG  . PRO A 1 21  ? -23.70111 50.44380 -8.30973  1.000 15.62943  ? 21  PRO A CG  1 
ATOM   154  C CD  . PRO A 1 21  ? -24.54817 50.60711 -9.54085  1.000 16.58943  ? 21  PRO A CD  1 
ATOM   155  N N   . GLU A 1 22  ? -20.49538 52.99330 -10.35641 1.000 17.55142  ? 22  GLU A N   1 
ATOM   156  C CA  . GLU A 1 22  ? -19.33217 53.20343 -11.22811 1.000 21.53142  ? 22  GLU A CA  1 
ATOM   157  C C   . GLU A 1 22  ? -18.64989 51.89939 -11.63062 1.000 16.77142  ? 22  GLU A C   1 
ATOM   158  O O   . GLU A 1 22  ? -18.02787 51.83399 -12.69939 1.000 18.44142  ? 22  GLU A O   1 
ATOM   159  C CB  . GLU A 1 22  ? -18.28711 54.07355 -10.52603 1.000 21.72142  ? 22  GLU A CB  1 
ATOM   160  C CG  . GLU A 1 22  ? -18.58660 55.52912 -10.41366 1.000 30.36142  ? 22  GLU A CG  1 
ATOM   161  C CD  . GLU A 1 22  ? -17.39564 56.29493 -9.82889  1.000 25.91142  ? 22  GLU A CD  1 
ATOM   162  O OE1 . GLU A 1 22  ? -16.93242 55.93886 -8.71897  1.000 26.69142  ? 22  GLU A OE1 1 
ATOM   163  O OE2 . GLU A 1 22  ? -16.93370 57.23819 -10.49665 1.000 36.26142  ? 22  GLU A OE2 1 
ATOM   164  N N   . ARG A 1 23  ? -18.71235 50.87173 -10.77478 1.000 17.28933  ? 23  ARG A N   1 
ATOM   165  C CA  . ARG A 1 23  ? -18.02843 49.61667 -11.06843 1.000 20.38933  ? 23  ARG A CA  1 
ATOM   166  C C   . ARG A 1 23  ? -18.53723 48.95031 -12.34147 1.000 18.36933  ? 23  ARG A C   1 
ATOM   167  O O   . ARG A 1 23  ? -17.78528 48.18296 -12.95422 1.000 21.25933  ? 23  ARG A O   1 
ATOM   168  C CB  . ARG A 1 23  ? -18.13489 48.65556 -9.87161  1.000 25.73933  ? 23  ARG A CB  1 
ATOM   169  C CG  . ARG A 1 23  ? -19.35247 47.76240 -9.84641  1.000 26.90933  ? 23  ARG A CG  1 
ATOM   170  C CD  . ARG A 1 23  ? -19.38971 46.90151 -8.58383  1.000 27.46933  ? 23  ARG A CD  1 
ATOM   171  N NE  . ARG A 1 23  ? -19.20898 45.47413 -8.83290  1.000 23.36933  ? 23  ARG A NE  1 
ATOM   172  C CZ  . ARG A 1 23  ? -19.55765 44.52044 -7.97450  1.000 27.40933  ? 23  ARG A CZ  1 
ATOM   173  N NH1 . ARG A 1 23  ? -20.12310 44.80925 -6.81305  1.000 25.07933  ? 23  ARG A NH1 1 
ATOM   174  N NH2 . ARG A 1 23  ? -19.34625 43.24503 -8.29328  1.000 26.59933  ? 23  ARG A NH2 1 
ATOM   175  N N   . TYR A 1 24  ? -19.76395 49.25376 -12.78193 1.000 16.89205  ? 24  TYR A N   1 
ATOM   176  C CA  . TYR A 1 24  ? -20.32034 48.67916 -14.00288 1.000 20.06205  ? 24  TYR A CA  1 
ATOM   177  C C   . TYR A 1 24  ? -20.10081 49.65365 -15.15082 1.000 21.35205  ? 24  TYR A C   1 
ATOM   178  O O   . TYR A 1 24  ? -20.59326 50.78676 -15.11144 1.000 20.98205  ? 24  TYR A O   1 
ATOM   179  C CB  . TYR A 1 24  ? -21.80499 48.33902 -13.83782 1.000 19.95205  ? 24  TYR A CB  1 
ATOM   180  C CG  . TYR A 1 24  ? -22.00812 47.39575 -12.68563 1.000 19.28205  ? 24  TYR A CG  1 
ATOM   181  C CD1 . TYR A 1 24  ? -21.51533 46.09240 -12.74851 1.000 15.96205  ? 24  TYR A CD1 1 
ATOM   182  C CD2 . TYR A 1 24  ? -22.63848 47.80988 -11.52418 1.000 18.55205  ? 24  TYR A CD2 1 
ATOM   183  C CE1 . TYR A 1 24  ? -21.64837 45.22876 -11.70169 1.000 18.31205  ? 24  TYR A CE1 1 
ATOM   184  C CE2 . TYR A 1 24  ? -22.78858 46.93549 -10.45541 1.000 18.04205  ? 24  TYR A CE2 1 
ATOM   185  C CZ  . TYR A 1 24  ? -22.29192 45.64958 -10.55057 1.000 16.71205  ? 24  TYR A CZ  1 
ATOM   186  O OH  . TYR A 1 24  ? -22.41580 44.75896 -9.51513  1.000 14.95205  ? 24  TYR A OH  1 
ATOM   187  N N   . GLN A 1 25  ? -19.36045 49.20485 -16.16733 1.000 20.32267  ? 25  GLN A N   1 
ATOM   188  C CA  . GLN A 1 25  ? -18.87704 50.05529 -17.24596 1.000 21.17267  ? 25  GLN A CA  1 
ATOM   189  C C   . GLN A 1 25  ? -19.24603 49.46608 -18.60586 1.000 22.17267  ? 25  GLN A C   1 
ATOM   190  O O   . GLN A 1 25  ? -19.46364 48.25779 -18.74741 1.000 25.02267  ? 25  GLN A O   1 
ATOM   191  C CB  . GLN A 1 25  ? -17.35437 50.24264 -17.15752 1.000 21.83267  ? 25  GLN A CB  1 
ATOM   192  C CG  . GLN A 1 25  ? -16.89519 51.12648 -16.00714 1.000 20.61267  ? 25  GLN A CG  1 
ATOM   193  C CD  . GLN A 1 25  ? -17.31083 52.57673 -16.19639 1.000 20.90267  ? 25  GLN A CD  1 
ATOM   194  O OE1 . GLN A 1 25  ? -17.28486 53.10669 -17.31272 1.000 22.39267  ? 25  GLN A OE1 1 
ATOM   195  N NE2 . GLN A 1 25  ? -17.71289 53.22127 -15.10731 1.000 20.61267  ? 25  GLN A NE2 1 
ATOM   196  N N   . ASN A 1 26  ? -19.31756 50.35402 -19.60027 1.000 24.00983  ? 26  ASN A N   1 
ATOM   197  C CA  . ASN A 1 26  ? -19.57870 50.00406 -21.00174 1.000 27.96983  ? 26  ASN A CA  1 
ATOM   198  C C   . ASN A 1 26  ? -20.88163 49.21649 -21.15658 1.000 27.03983  ? 26  ASN A C   1 
ATOM   199  O O   . ASN A 1 26  ? -20.90751 48.11659 -21.71595 1.000 23.26983  ? 26  ASN A O   1 
ATOM   200  C CB  . ASN A 1 26  ? -18.40589 49.22596 -21.61250 1.000 32.27983  ? 26  ASN A CB  1 
ATOM   201  C CG  . ASN A 1 26  ? -17.07323 49.97581 -21.52369 1.000 35.30983  ? 26  ASN A CG  1 
ATOM   202  O OD1 . ASN A 1 26  ? -17.02295 51.20832 -21.46449 1.000 34.01983  ? 26  ASN A OD1 1 
ATOM   203  N ND2 . ASN A 1 26  ? -15.98796 49.22067 -21.51970 1.000 36.49983  ? 26  ASN A ND2 1 
ATOM   204  N N   . LEU A 1 27  ? -21.97039 49.78213 -20.63603 1.000 24.13087  ? 27  LEU A N   1 
ATOM   205  C CA  . LEU A 1 27  ? -23.27364 49.13302 -20.74314 1.000 26.41087  ? 27  LEU A CA  1 
ATOM   206  C C   . LEU A 1 27  ? -23.75304 49.14808 -22.19118 1.000 30.16087  ? 27  LEU A C   1 
ATOM   207  O O   . LEU A 1 27  ? -23.78898 50.20456 -22.82865 1.000 27.74087  ? 27  LEU A O   1 
ATOM   208  C CB  . LEU A 1 27  ? -24.30112 49.83806 -19.85207 1.000 25.21087  ? 27  LEU A CB  1 
ATOM   209  C CG  . LEU A 1 27  ? -24.44280 49.45937 -18.37288 1.000 26.32087  ? 27  LEU A CG  1 
ATOM   210  C CD1 . LEU A 1 27  ? -23.16646 49.70325 -17.58046 1.000 23.59087  ? 27  LEU A CD1 1 
ATOM   211  C CD2 . LEU A 1 27  ? -25.59214 50.25186 -17.76792 1.000 31.70087  ? 27  LEU A CD2 1 
ATOM   212  N N   . SER A 1 28  ? -24.15097 47.98291 -22.70061 1.000 31.78621  ? 28  SER A N   1 
ATOM   213  C CA  . SER A 1 28  ? -24.67853 47.86440 -24.05778 1.000 34.74621  ? 28  SER A CA  1 
ATOM   214  C C   . SER A 1 28  ? -26.01134 47.13137 -24.00814 1.000 31.12621  ? 28  SER A C   1 
ATOM   215  O O   . SER A 1 28  ? -26.04973 45.96122 -23.57130 1.000 29.40621  ? 28  SER A O   1 
ATOM   216  C CB  . SER A 1 28  ? -23.70111 47.12183 -24.97194 1.000 39.95621  ? 28  SER A CB  1 
ATOM   217  O OG  . SER A 1 28  ? -22.36556 47.50093 -24.69639 1.000 48.98621  ? 28  SER A OG  1 
ATOM   218  N N   . PRO A 1 29  ? -27.10629 47.75639 -24.45298 1.000 35.12879  ? 29  PRO A N   1 
ATOM   219  C CA  . PRO A 1 29  ? -28.42618 47.09777 -24.45173 1.000 41.17879  ? 29  PRO A CA  1 
ATOM   220  C C   . PRO A 1 29  ? -28.45705 45.82544 -25.28552 1.000 40.90879  ? 29  PRO A C   1 
ATOM   221  O O   . PRO A 1 29  ? -28.00520 45.80521 -26.43068 1.000 54.41879  ? 29  PRO A O   1 
ATOM   222  C CB  . PRO A 1 29  ? -29.34567 48.16702 -25.05023 1.000 39.84879  ? 29  PRO A CB  1 
ATOM   223  C CG  . PRO A 1 29  ? -28.67076 49.45363 -24.73387 1.000 39.70879  ? 29  PRO A CG  1 
ATOM   224  C CD  . PRO A 1 29  ? -27.20054 49.18366 -24.80166 1.000 37.71879  ? 29  PRO A CD  1 
ATOM   225  N N   . VAL A 1 30  ? -28.98824 44.75003 -24.69622 1.000 35.10264  ? 30  VAL A N   1 
ATOM   226  C CA  . VAL A 1 30  ? -29.01673 43.44922 -25.36270 1.000 44.70264  ? 30  VAL A CA  1 
ATOM   227  C C   . VAL A 1 30  ? -30.38421 42.78516 -25.23294 1.000 46.14264  ? 30  VAL A C   1 
ATOM   228  O O   . VAL A 1 30  ? -30.51535 41.58009 -25.47965 1.000 48.97264  ? 30  VAL A O   1 
ATOM   229  C CB  . VAL A 1 30  ? -27.92347 42.49978 -24.82337 1.000 49.30264  ? 30  VAL A CB  1 
ATOM   230  C CG1 . VAL A 1 30  ? -26.51638 43.03470 -25.10357 1.000 54.74264  ? 30  VAL A CG1 1 
ATOM   231  C CG2 . VAL A 1 30  ? -28.12124 42.21490 -23.34146 1.000 50.74264  ? 30  VAL A CG2 1 
ATOM   232  N N   . GLY A 1 31  ? -31.40617 43.53772 -24.85229 1.000 44.68382  ? 31  GLY A N   1 
ATOM   233  C CA  . GLY A 1 31  ? -32.71170 42.92759 -24.68838 1.000 52.37382  ? 31  GLY A CA  1 
ATOM   234  C C   . GLY A 1 31  ? -33.66376 43.80052 -23.90612 1.000 58.26382  ? 31  GLY A C   1 
ATOM   235  O O   . GLY A 1 31  ? -33.26785 44.67978 -23.13445 1.000 54.49382  ? 31  GLY A O   1 
ATOM   236  N N   . SER A 1 32  ? -34.95475 43.52512 -24.09773 1.000 61.79169  ? 32  SER A N   1 
ATOM   237  C CA  . SER A 1 32  ? -36.02165 44.36611 -23.56955 1.000 65.16169  ? 32  SER A CA  1 
ATOM   238  C C   . SER A 1 32  ? -37.31697 43.55981 -23.56213 1.000 66.08169  ? 32  SER A C   1 
ATOM   239  O O   . SER A 1 32  ? -37.39748 42.47763 -24.14950 1.000 63.28169  ? 32  SER A O   1 
ATOM   240  C CB  . SER A 1 32  ? -36.16104 45.64890 -24.39983 1.000 64.81169  ? 32  SER A CB  1 
ATOM   241  O OG  . SER A 1 32  ? -36.89429 46.63893 -23.70572 1.000 64.44169  ? 32  SER A OG  1 
ATOM   242  N N   . GLY A 1 33  ? -38.33063 44.09617 -22.88650 1.000 66.49781  ? 33  GLY A N   1 
ATOM   243  C CA  . GLY A 1 33  ? -39.62641 43.44701 -22.81934 1.000 71.07781  ? 33  GLY A CA  1 
ATOM   244  C C   . GLY A 1 33  ? -40.37732 43.80692 -21.54767 1.000 75.67781  ? 33  GLY A C   1 
ATOM   245  O O   . GLY A 1 33  ? -40.01537 44.73490 -20.82707 1.000 80.87781  ? 33  GLY A O   1 
ATOM   246  N N   . ALA A 1 34  ? -41.44181 43.03355 -21.28907 1.000 74.04446  ? 34  ALA A N   1 
ATOM   247  C CA  . ALA A 1 34  ? -42.32761 43.29427 -20.15779 1.000 73.29446  ? 34  ALA A CA  1 
ATOM   248  C C   . ALA A 1 34  ? -41.72174 42.87862 -18.82073 1.000 79.19446  ? 34  ALA A C   1 
ATOM   249  O O   . ALA A 1 34  ? -42.19723 43.33586 -17.77360 1.000 89.69446  ? 34  ALA A O   1 
ATOM   250  C CB  . ALA A 1 34  ? -43.66653 42.57993 -20.36296 1.000 70.55446  ? 34  ALA A CB  1 
ATOM   251  N N   . TYR A 1 35  ? -40.69622 42.02173 -18.82729 1.000 82.21056  ? 35  TYR A N   1 
ATOM   252  C CA  . TYR A 1 35  ? -39.99686 41.64700 -17.60244 1.000 72.16056  ? 35  TYR A CA  1 
ATOM   253  C C   . TYR A 1 35  ? -38.92274 42.65218 -17.19837 1.000 68.67056  ? 35  TYR A C   1 
ATOM   254  O O   . TYR A 1 35  ? -38.52409 42.67848 -16.02651 1.000 61.02056  ? 35  TYR A O   1 
ATOM   255  C CB  . TYR A 1 35  ? -39.35651 40.26071 -17.75757 1.000 61.01056  ? 35  TYR A CB  1 
ATOM   256  N N   . GLY A 1 36  ? -38.46083 43.48397 -18.13047 1.000 66.40386  ? 36  GLY A N   1 
ATOM   257  C CA  . GLY A 1 36  ? -37.37319 44.40793 -17.87640 1.000 57.97386  ? 36  GLY A CA  1 
ATOM   258  C C   . GLY A 1 36  ? -36.37638 44.42463 -19.01780 1.000 54.11386  ? 36  GLY A C   1 
ATOM   259  O O   . GLY A 1 36  ? -36.46783 43.60155 -19.93651 1.000 58.92386  ? 36  GLY A O   1 
ATOM   260  N N   . SER A 1 37  ? -35.42772 45.35786 -18.98393 1.000 50.40939  ? 37  SER A N   1 
ATOM   261  C CA  . SER A 1 37  ? -34.39131 45.45018 -19.99977 1.000 39.12939  ? 37  SER A CA  1 
ATOM   262  C C   . SER A 1 37  ? -33.04700 45.03082 -19.42197 1.000 36.19939  ? 37  SER A C   1 
ATOM   263  O O   . SER A 1 37  ? -32.80639 45.13738 -18.21418 1.000 27.94939  ? 37  SER A O   1 
ATOM   264  C CB  . SER A 1 37  ? -34.29954 46.86026 -20.56564 1.000 41.42939  ? 37  SER A CB  1 
ATOM   265  O OG  . SER A 1 37  ? -34.12710 47.78482 -19.51260 1.000 54.81939  ? 37  SER A OG  1 
ATOM   266  N N   . VAL A 1 38  ? -32.17785 44.53720 -20.30276 1.000 31.87932  ? 38  VAL A N   1 
ATOM   267  C CA  . VAL A 1 38  ? -30.90260 43.94201 -19.93408 1.000 28.24932  ? 38  VAL A CA  1 
ATOM   268  C C   . VAL A 1 38  ? -29.79866 44.64337 -20.71476 1.000 37.58932  ? 38  VAL A C   1 
ATOM   269  O O   . VAL A 1 38  ? -29.92980 44.86421 -21.92659 1.000 29.83932  ? 38  VAL A O   1 
ATOM   270  C CB  . VAL A 1 38  ? -30.87879 42.42636 -20.21194 1.000 30.60932  ? 38  VAL A CB  1 
ATOM   271  C CG1 . VAL A 1 38  ? -29.57887 41.81656 -19.73870 1.000 34.07932  ? 38  VAL A CG1 1 
ATOM   272  C CG2 . VAL A 1 38  ? -32.04534 41.72985 -19.52804 1.000 35.18932  ? 38  VAL A CG2 1 
ATOM   273  N N   . CYS A 1 39  ? -28.72188 45.00232 -20.01778 1.000 24.97943  ? 39  CYS A N   1 
ATOM   274  C CA  . CYS A 1 39  ? -27.49111 45.45403 -20.63743 1.000 26.84943  ? 39  CYS A CA  1 
ATOM   275  C C   . CYS A 1 39  ? -26.38238 44.47114 -20.31922 1.000 28.02943  ? 39  CYS A C   1 
ATOM   276  O O   . CYS A 1 39  ? -26.28190 43.98562 -19.18988 1.000 30.32943  ? 39  CYS A O   1 
ATOM   277  C CB  . CYS A 1 39  ? -27.08515 46.84082 -20.13931 1.000 27.76943  ? 39  CYS A CB  1 
ATOM   278  S SG  . CYS A 1 39  ? -28.02109 48.20013 -20.87605 1.000 36.91943  ? 39  CYS A SG  1 
ATOM   279  N N   . ALA A 1 40  ? -25.54956 44.17343 -21.31242 1.000 30.98935  ? 40  ALA A N   1 
ATOM   280  C CA  . ALA A 1 40  ? -24.24458 43.60802 -21.01789 1.000 31.26935  ? 40  ALA A CA  1 
ATOM   281  C C   . ALA A 1 40  ? -23.34662 44.71968 -20.49148 1.000 27.82935  ? 40  ALA A C   1 
ATOM   282  O O   . ALA A 1 40  ? -23.46817 45.87534 -20.89783 1.000 28.42935  ? 40  ALA A O   1 
ATOM   283  C CB  . ALA A 1 40  ? -23.62157 42.97865 -22.26625 1.000 36.07935  ? 40  ALA A CB  1 
ATOM   284  N N   . ALA A 1 41  ? -22.44348 44.36797 -19.58211 1.000 25.72218  ? 41  ALA A N   1 
ATOM   285  C CA  . ALA A 1 41  ? -21.56511 45.37278 -18.99697 1.000 26.69218  ? 41  ALA A CA  1 
ATOM   286  C C   . ALA A 1 41  ? -20.29528 44.70136 -18.50110 1.000 24.53218  ? 41  ALA A C   1 
ATOM   287  O O   . ALA A 1 41  ? -20.22708 43.47952 -18.34907 1.000 25.58218  ? 41  ALA A O   1 
ATOM   288  C CB  . ALA A 1 41  ? -22.24913 46.11877 -17.84312 1.000 27.22218  ? 41  ALA A CB  1 
ATOM   289  N N   . PHE A 1 42  ? -19.29990 45.52799 -18.20641 1.000 24.00691  ? 42  PHE A N   1 
ATOM   290  C CA  . PHE A 1 42  ? -18.04337 45.05844 -17.64829 1.000 20.88691  ? 42  PHE A CA  1 
ATOM   291  C C   . PHE A 1 42  ? -18.01202 45.40912 -16.16759 1.000 20.48691  ? 42  PHE A C   1 
ATOM   292  O O   . PHE A 1 42  ? -18.09294 46.58631 -15.80448 1.000 22.76691  ? 42  PHE A O   1 
ATOM   293  C CB  . PHE A 1 42  ? -16.84773 45.67454 -18.37931 1.000 22.70691  ? 42  PHE A CB  1 
ATOM   294  C CG  . PHE A 1 42  ? -15.52708 45.19633 -17.85104 1.000 28.89691  ? 42  PHE A CG  1 
ATOM   295  C CD1 . PHE A 1 42  ? -15.14293 43.86805 -18.02061 1.000 30.58691  ? 42  PHE A CD1 1 
ATOM   296  C CD2 . PHE A 1 42  ? -14.68023 46.06076 -17.16365 1.000 29.66691  ? 42  PHE A CD2 1 
ATOM   297  C CE1 . PHE A 1 42  ? -13.93680 43.41303 -17.51022 1.000 31.95691  ? 42  PHE A CE1 1 
ATOM   298  C CE2 . PHE A 1 42  ? -13.48000 45.61883 -16.65739 1.000 30.36691  ? 42  PHE A CE2 1 
ATOM   299  C CZ  . PHE A 1 42  ? -13.10382 44.29383 -16.82853 1.000 33.62691  ? 42  PHE A CZ  1 
ATOM   300  N N   . ASP A 1 43  ? -17.88808 44.39509 -15.31738 1.000 21.44923  ? 43  ASP A N   1 
ATOM   301  C CA  . ASP A 1 43  ? -17.77482 44.60847 -13.88177 1.000 23.90923  ? 43  ASP A CA  1 
ATOM   302  C C   . ASP A 1 43  ? -16.30420 44.79039 -13.53923 1.000 26.54923  ? 43  ASP A C   1 
ATOM   303  O O   . ASP A 1 43  ? -15.54727 43.81534 -13.47155 1.000 22.47923  ? 43  ASP A O   1 
ATOM   304  C CB  . ASP A 1 43  ? -18.38555 43.44744 -13.10126 1.000 24.79923  ? 43  ASP A CB  1 
ATOM   305  C CG  . ASP A 1 43  ? -18.21648 43.59674 -11.58724 1.000 25.42923  ? 43  ASP A CG  1 
ATOM   306  O OD1 . ASP A 1 43  ? -17.84355 44.68825 -11.10106 1.000 26.57923  ? 43  ASP A OD1 1 
ATOM   307  O OD2 . ASP A 1 43  ? -18.46797 42.61089 -10.86466 1.000 26.40923  ? 43  ASP A OD2 1 
ATOM   308  N N   . THR A 1 44  ? -15.92742 46.02711 -13.21908 1.000 22.55704  ? 44  THR A N   1 
ATOM   309  C CA  . THR A 1 44  ? -14.53058 46.31632 -12.92715 1.000 24.26704  ? 44  THR A CA  1 
ATOM   310  C C   . THR A 1 44  ? -14.07949 45.76343 -11.58242 1.000 24.08704  ? 44  THR A C   1 
ATOM   311  O O   . THR A 1 44  ? -12.87318 45.68494 -11.34168 1.000 29.86704  ? 44  THR A O   1 
ATOM   312  C CB  . THR A 1 44  ? -14.28361 47.82921 -12.98123 1.000 22.66704  ? 44  THR A CB  1 
ATOM   313  O OG1 . THR A 1 44  ? -15.02440 48.47039 -11.94018 1.000 25.22704  ? 44  THR A OG1 1 
ATOM   314  C CG2 . THR A 1 44  ? -14.71138 48.38813 -14.33158 1.000 24.57704  ? 44  THR A CG2 1 
ATOM   315  N N   . LYS A 1 45  ? -15.00112 45.37926 -10.69516 1.000 22.10769  ? 45  LYS A N   1 
ATOM   316  C CA  . LYS A 1 45  ? -14.56845 44.80122 -9.42628  1.000 27.93769  ? 45  LYS A CA  1 
ATOM   317  C C   . LYS A 1 45  ? -14.14466 43.34054 -9.59030  1.000 29.74769  ? 45  LYS A C   1 
ATOM   318  O O   . LYS A 1 45  ? -13.13650 42.91823 -9.01740  1.000 32.47769  ? 45  LYS A O   1 
ATOM   319  C CB  . LYS A 1 45  ? -15.67736 44.93281 -8.37928  1.000 34.49769  ? 45  LYS A CB  1 
ATOM   320  C CG  . LYS A 1 45  ? -15.29165 44.41506 -6.99628  1.000 42.92769  ? 45  LYS A CG  1 
ATOM   321  C CD  . LYS A 1 45  ? -16.51693 44.19772 -6.12263  1.000 51.79769  ? 45  LYS A CD  1 
ATOM   322  C CE  . LYS A 1 45  ? -16.17096 43.46345 -4.83222  1.000 61.97769  ? 45  LYS A CE  1 
ATOM   323  N NZ  . LYS A 1 45  ? -15.37405 44.29739 -3.88493  1.000 71.41769  ? 45  LYS A NZ  1 
ATOM   324  N N   . THR A 1 46  ? -14.88142 42.56181 -10.38030 1.000 28.79673  ? 46  THR A N   1 
ATOM   325  C CA  . THR A 1 46  ? -14.53445 41.16499 -10.61890 1.000 34.66673  ? 46  THR A CA  1 
ATOM   326  C C   . THR A 1 46  ? -13.71863 40.96921 -11.88765 1.000 41.27673  ? 46  THR A C   1 
ATOM   327  O O   . THR A 1 46  ? -13.04902 39.93941 -12.02759 1.000 45.50673  ? 46  THR A O   1 
ATOM   328  C CB  . THR A 1 46  ? -15.79891 40.29306 -10.69876 1.000 31.41673  ? 46  THR A CB  1 
ATOM   329  O OG1 . THR A 1 46  ? -16.66030 40.76854 -11.74249 1.000 34.11673  ? 46  THR A OG1 1 
ATOM   330  C CG2 . THR A 1 46  ? -16.55782 40.32683 -9.38721  1.000 36.67673  ? 46  THR A CG2 1 
ATOM   331  N N   . GLY A 1 47  ? -13.74077 41.93296 -12.80208 1.000 36.52755  ? 47  GLY A N   1 
ATOM   332  C CA  . GLY A 1 47  ? -13.06822 41.75753 -14.06842 1.000 33.95755  ? 47  GLY A CA  1 
ATOM   333  C C   . GLY A 1 47  ? -13.81585 40.87529 -15.03496 1.000 34.77755  ? 47  GLY A C   1 
ATOM   334  O O   . GLY A 1 47  ? -13.23951 40.43221 -16.03360 1.000 39.48755  ? 47  GLY A O   1 
ATOM   335  N N   . HIS A 1 48  ? -15.08995 40.61370 -14.77573 1.000 33.04413  ? 48  HIS A N   1 
ATOM   336  C CA  . HIS A 1 48  ? -15.89272 39.74370 -15.61561 1.000 33.14413  ? 48  HIS A CA  1 
ATOM   337  C C   . HIS A 1 48  ? -16.94610 40.55566 -16.34377 1.000 29.32413  ? 48  HIS A C   1 
ATOM   338  O O   . HIS A 1 48  ? -17.32484 41.64204 -15.90906 1.000 26.37413  ? 48  HIS A O   1 
ATOM   339  C CB  . HIS A 1 48  ? -16.55893 38.64309 -14.78100 1.000 37.63413  ? 48  HIS A CB  1 
ATOM   340  C CG  . HIS A 1 48  ? -15.58454 37.69138 -14.15617 1.000 52.08413  ? 48  HIS A CG  1 
ATOM   341  N ND1 . HIS A 1 48  ? -14.62830 37.01916 -14.88841 1.000 60.26413  ? 48  HIS A ND1 1 
ATOM   342  C CD2 . HIS A 1 48  ? -15.41633 37.29897 -12.87056 1.000 62.12413  ? 48  HIS A CD2 1 
ATOM   343  C CE1 . HIS A 1 48  ? -13.91047 36.25817 -14.08133 1.000 69.08413  ? 48  HIS A CE1 1 
ATOM   344  N NE2 . HIS A 1 48  ? -14.36837 36.40886 -12.85135 1.000 69.20413  ? 48  HIS A NE2 1 
ATOM   345  N N   . ARG A 1 49  ? -17.39645 40.02389 -17.47612 1.000 26.09991  ? 49  ARG A N   1 
ATOM   346  C CA  . ARG A 1 49  ? -18.58520 40.53790 -18.13468 1.000 27.08991  ? 49  ARG A CA  1 
ATOM   347  C C   . ARG A 1 49  ? -19.81284 40.06755 -17.36129 1.000 25.66991  ? 49  ARG A C   1 
ATOM   348  O O   . ARG A 1 49  ? -19.84351 38.94704 -16.84713 1.000 22.22991  ? 49  ARG A O   1 
ATOM   349  C CB  . ARG A 1 49  ? -18.66052 40.05654 -19.58828 1.000 36.99991  ? 49  ARG A CB  1 
ATOM   350  C CG  . ARG A 1 49  ? -17.54627 40.56379 -20.50724 1.000 51.91991  ? 49  ARG A CG  1 
ATOM   351  C CD  . ARG A 1 49  ? -17.77832 42.01128 -20.95766 1.000 65.55991  ? 49  ARG A CD  1 
ATOM   352  N NE  . ARG A 1 49  ? -18.77362 42.12454 -22.02058 1.000 76.58991  ? 49  ARG A NE  1 
ATOM   353  C CZ  . ARG A 1 49  ? -19.24181 43.27269 -22.49679 1.000 76.15991  ? 49  ARG A CZ  1 
ATOM   354  N NH1 . ARG A 1 49  ? -18.82796 44.43919 -22.02669 1.000 70.50991  ? 49  ARG A NH1 1 
ATOM   355  N NH2 . ARG A 1 49  ? -20.15220 43.25013 -23.46702 1.000 74.47991  ? 49  ARG A NH2 1 
ATOM   356  N N   . VAL A 1 50  ? -20.81265 40.94601 -17.24940 1.000 28.40900  ? 50  VAL A N   1 
ATOM   357  C CA  . VAL A 1 50  ? -22.01203 40.68715 -16.46413 1.000 26.56900  ? 50  VAL A CA  1 
ATOM   358  C C   . VAL A 1 50  ? -23.22973 41.12159 -17.26683 1.000 26.11900  ? 50  VAL A C   1 
ATOM   359  O O   . VAL A 1 50  ? -23.13971 41.91762 -18.20515 1.000 28.81900  ? 50  VAL A O   1 
ATOM   360  C CB  . VAL A 1 50  ? -22.00194 41.41088 -15.09012 1.000 23.55900  ? 50  VAL A CB  1 
ATOM   361  C CG1 . VAL A 1 50  ? -20.88611 40.88605 -14.19796 1.000 23.06900  ? 50  VAL A CG1 1 
ATOM   362  C CG2 . VAL A 1 50  ? -21.91096 42.93177 -15.29073 1.000 22.39900  ? 50  VAL A CG2 1 
ATOM   363  N N   . ALA A 1 51  ? -24.37680 40.55552 -16.90065 1.000 28.40333  ? 51  ALA A N   1 
ATOM   364  C CA  . ALA A 1 51  ? -25.66714 41.03243 -17.36981 1.000 26.19333  ? 51  ALA A CA  1 
ATOM   365  C C   . ALA A 1 51  ? -26.30018 41.85086 -16.25338 1.000 21.65333  ? 51  ALA A C   1 
ATOM   366  O O   . ALA A 1 51  ? -26.38885 41.38316 -15.11713 1.000 18.95333  ? 51  ALA A O   1 
ATOM   367  C CB  . ALA A 1 51  ? -26.58423 39.87328 -17.76390 1.000 24.60333  ? 51  ALA A CB  1 
ATOM   368  N N   . VAL A 1 52  ? -26.71212 43.07082 -16.57378 1.000 21.44868  ? 52  VAL A N   1 
ATOM   369  C CA  . VAL A 1 52  ? -27.39786 43.95462 -15.63846 1.000 22.65868  ? 52  VAL A CA  1 
ATOM   370  C C   . VAL A 1 52  ? -28.83891 44.06712 -16.10533 1.000 22.92868  ? 52  VAL A C   1 
ATOM   371  O O   . VAL A 1 52  ? -29.09515 44.55269 -17.21441 1.000 25.29868  ? 52  VAL A O   1 
ATOM   372  C CB  . VAL A 1 52  ? -26.73279 45.33846 -15.56966 1.000 22.80868  ? 52  VAL A CB  1 
ATOM   373  C CG1 . VAL A 1 52  ? -27.45298 46.22422 -14.54304 1.000 22.72868  ? 52  VAL A CG1 1 
ATOM   374  C CG2 . VAL A 1 52  ? -25.24459 45.20232 -15.21792 1.000 22.90868  ? 52  VAL A CG2 1 
ATOM   375  N N   . LYS A 1 53  ? -29.77559 43.60980 -15.27379 1.000 21.58639  ? 53  LYS A N   1 
ATOM   376  C CA  . LYS A 1 53  ? -31.20130 43.64604 -15.59350 1.000 20.06639  ? 53  LYS A CA  1 
ATOM   377  C C   . LYS A 1 53  ? -31.88749 44.72825 -14.76931 1.000 19.25639  ? 53  LYS A C   1 
ATOM   378  O O   . LYS A 1 53  ? -31.86041 44.67834 -13.53517 1.000 16.75639  ? 53  LYS A O   1 
ATOM   379  C CB  . LYS A 1 53  ? -31.86197 42.29673 -15.31759 1.000 23.53639  ? 53  LYS A CB  1 
ATOM   380  C CG  . LYS A 1 53  ? -33.36224 42.30520 -15.66682 1.000 31.40639  ? 53  LYS A CG  1 
ATOM   381  C CD  . LYS A 1 53  ? -33.93788 40.90317 -15.87709 1.000 39.93639  ? 53  LYS A CD  1 
ATOM   382  C CE  . LYS A 1 53  ? -34.14629 40.17557 -14.55197 1.000 51.37639  ? 53  LYS A CE  1 
ATOM   383  N NZ  . LYS A 1 53  ? -34.96828 38.93301 -14.69495 1.000 58.88639  ? 53  LYS A NZ  1 
ATOM   384  N N   . LYS A 1 54  ? -32.51147 45.68645 -15.43768 1.000 19.27044  ? 54  LYS A N   1 
ATOM   385  C CA  . LYS A 1 54  ? -33.31668 46.69173 -14.76127 1.000 21.42044  ? 54  LYS A CA  1 
ATOM   386  C C   . LYS A 1 54  ? -34.76914 46.23807 -14.79639 1.000 25.16044  ? 54  LYS A C   1 
ATOM   387  O O   . LYS A 1 54  ? -35.33550 46.06715 -15.88014 1.000 23.99044  ? 54  LYS A O   1 
ATOM   388  C CB  . LYS A 1 54  ? -33.17401 48.06098 -15.41284 1.000 22.54044  ? 54  LYS A CB  1 
ATOM   389  C CG  . LYS A 1 54  ? -34.01822 49.11606 -14.72464 1.000 24.26044  ? 54  LYS A CG  1 
ATOM   390  C CD  . LYS A 1 54  ? -33.89390 50.47183 -15.38535 1.000 26.63044  ? 54  LYS A CD  1 
ATOM   391  C CE  . LYS A 1 54  ? -34.59195 51.54174 -14.54873 1.000 30.68044  ? 54  LYS A CE  1 
ATOM   392  N NZ  . LYS A 1 54  ? -34.99921 52.72380 -15.35125 1.000 31.50044  ? 54  LYS A NZ  1 
ATOM   393  N N   . LEU A 1 55  ? -35.36490 46.02977 -13.62336 1.000 22.86720  ? 55  LEU A N   1 
ATOM   394  C CA  . LEU A 1 55  ? -36.72945 45.52274 -13.59986 1.000 26.98720  ? 55  LEU A CA  1 
ATOM   395  C C   . LEU A 1 55  ? -37.69783 46.59086 -14.09198 1.000 26.53720  ? 55  LEU A C   1 
ATOM   396  O O   . LEU A 1 55  ? -37.55702 47.78257 -13.79387 1.000 25.45720  ? 55  LEU A O   1 
ATOM   397  C CB  . LEU A 1 55  ? -37.11193 45.04418 -12.20692 1.000 25.14720  ? 55  LEU A CB  1 
ATOM   398  C CG  . LEU A 1 55  ? -36.40268 43.75777 -11.78449 1.000 26.82720  ? 55  LEU A CG  1 
ATOM   399  C CD1 . LEU A 1 55  ? -36.91666 43.31755 -10.42243 1.000 26.20720  ? 55  LEU A CD1 1 
ATOM   400  C CD2 . LEU A 1 55  ? -36.58506 42.64046 -12.80021 1.000 27.95720  ? 55  LEU A CD2 1 
ATOM   401  N N   . SER A 1 56  ? -38.65730 46.16443 -14.90229 1.000 33.62296  ? 56  SER A N   1 
ATOM   402  C CA  . SER A 1 56  ? -39.63510 47.08582 -15.45405 1.000 40.12296  ? 56  SER A CA  1 
ATOM   403  C C   . SER A 1 56  ? -40.88883 47.09246 -14.59491 1.000 35.24296  ? 56  SER A C   1 
ATOM   404  O O   . SER A 1 56  ? -41.48858 46.03191 -14.36089 1.000 35.50296  ? 56  SER A O   1 
ATOM   405  C CB  . SER A 1 56  ? -39.98472 46.72497 -16.89750 1.000 47.66296  ? 56  SER A CB  1 
ATOM   406  O OG  . SER A 1 56  ? -40.86253 47.70671 -17.43851 1.000 54.52296  ? 56  SER A OG  1 
ATOM   407  N N   . ARG A 1 57  ? -41.28066 48.29513 -14.15091 1.000 31.08454  ? 57  ARG A N   1 
ATOM   408  C CA  . ARG A 1 57  ? -42.49520 48.50948 -13.36820 1.000 40.27454  ? 57  ARG A CA  1 
ATOM   409  C C   . ARG A 1 57  ? -42.57782 47.59268 -12.14260 1.000 31.01454  ? 57  ARG A C   1 
ATOM   410  O O   . ARG A 1 57  ? -43.58646 46.90491 -11.95343 1.000 33.89454  ? 57  ARG A O   1 
ATOM   411  C CB  . ARG A 1 57  ? -43.73752 48.31579 -14.22929 1.000 46.14454  ? 57  ARG A CB  1 
ATOM   412  C CG  . ARG A 1 57  ? -43.75347 49.03129 -15.57940 1.000 59.43454  ? 57  ARG A CG  1 
ATOM   413  C CD  . ARG A 1 57  ? -43.93714 50.52436 -15.41135 1.000 68.29454  ? 57  ARG A CD  1 
ATOM   414  N NE  . ARG A 1 57  ? -44.11347 51.18872 -16.69625 1.000 80.98454  ? 57  ARG A NE  1 
ATOM   415  C CZ  . ARG A 1 57  ? -44.00549 52.49640 -16.88223 1.000 96.72454  ? 57  ARG A CZ  1 
ATOM   416  N NH1 . ARG A 1 57  ? -43.70870 53.31306 -15.88487 1.000 102.58454 ? 57  ARG A NH1 1 
ATOM   417  N NH2 . ARG A 1 57  ? -44.19567 52.99664 -18.09992 1.000 105.68454 ? 57  ARG A NH2 1 
ATOM   418  N N   . PRO A 1 58  ? -41.51940 47.52408 -11.31938 1.000 28.48014  ? 58  PRO A N   1 
ATOM   419  C CA  . PRO A 1 58  ? -41.44729 46.40595 -10.36472 1.000 25.92014  ? 58  PRO A CA  1 
ATOM   420  C C   . PRO A 1 58  ? -42.52471 46.46912 -9.29315  1.000 20.82014  ? 58  PRO A C   1 
ATOM   421  O O   . PRO A 1 58  ? -42.91302 45.42009 -8.77429  1.000 25.57014  ? 58  PRO A O   1 
ATOM   422  C CB  . PRO A 1 58  ? -40.03290 46.52790 -9.77395  1.000 24.68014  ? 58  PRO A CB  1 
ATOM   423  C CG  . PRO A 1 58  ? -39.72110 47.97776 -9.85369  1.000 26.62014  ? 58  PRO A CG  1 
ATOM   424  C CD  . PRO A 1 58  ? -40.45409 48.52224 -11.07105 1.000 28.07014  ? 58  PRO A CD  1 
ATOM   425  N N   . PHE A 1 59  ? -43.04961 47.65422 -8.99578  1.000 21.50701  ? 59  PHE A N   1 
ATOM   426  C CA  . PHE A 1 59  ? -44.02105 47.86515 -7.92485  1.000 25.50701  ? 59  PHE A CA  1 
ATOM   427  C C   . PHE A 1 59  ? -45.25571 48.60370 -8.44067  1.000 31.43701  ? 59  PHE A C   1 
ATOM   428  O O   . PHE A 1 59  ? -45.85619 49.42518 -7.73557  1.000 33.30701  ? 59  PHE A O   1 
ATOM   429  C CB  . PHE A 1 59  ? -43.37453 48.61601 -6.76714  1.000 25.70701  ? 59  PHE A CB  1 
ATOM   430  C CG  . PHE A 1 59  ? -42.06073 48.03017 -6.33972  1.000 23.00701  ? 59  PHE A CG  1 
ATOM   431  C CD1 . PHE A 1 59  ? -42.00835 46.76211 -5.78719  1.000 20.17701  ? 59  PHE A CD1 1 
ATOM   432  C CD2 . PHE A 1 59  ? -40.88364 48.74445 -6.49121  1.000 21.51701  ? 59  PHE A CD2 1 
ATOM   433  C CE1 . PHE A 1 59  ? -40.79808 46.21246 -5.37326  1.000 18.06701  ? 59  PHE A CE1 1 
ATOM   434  C CE2 . PHE A 1 59  ? -39.66020 48.20337 -6.09200  1.000 20.29701  ? 59  PHE A CE2 1 
ATOM   435  C CZ  . PHE A 1 59  ? -39.61956 46.93568 -5.53159  1.000 18.40701  ? 59  PHE A CZ  1 
ATOM   436  N N   . GLN A 1 60  ? -45.65458 48.30665 -9.68238  1.000 30.88437  ? 60  GLN A N   1 
ATOM   437  C CA  . GLN A 1 60  ? -46.80610 48.96046 -10.29927 1.000 36.98437  ? 60  GLN A CA  1 
ATOM   438  C C   . GLN A 1 60  ? -48.12424 48.41176 -9.76089  1.000 34.13437  ? 60  GLN A C   1 
ATOM   439  O O   . GLN A 1 60  ? -49.11189 49.14744 -9.67656  1.000 33.05437  ? 60  GLN A O   1 
ATOM   440  C CB  . GLN A 1 60  ? -46.74456 48.80246 -11.82440 1.000 39.31437  ? 60  GLN A CB  1 
ATOM   441  C CG  . GLN A 1 60  ? -47.87931 49.51798 -12.56888 1.000 57.18437  ? 60  GLN A CG  1 
ATOM   442  C CD  . GLN A 1 60  ? -47.86269 49.30391 -14.07465 1.000 70.12437  ? 60  GLN A CD  1 
ATOM   443  O OE1 . GLN A 1 60  ? -46.93916 48.70379 -14.62601 1.000 74.16437  ? 60  GLN A OE1 1 
ATOM   444  N NE2 . GLN A 1 60  ? -48.89642 49.80079 -14.74822 1.000 79.74437  ? 60  GLN A NE2 1 
ATOM   445  N N   . SER A 1 61  ? -48.15318 47.14171 -9.37000  1.000 31.74760  ? 61  SER A N   1 
ATOM   446  C CA  . SER A 1 61  ? -49.33302 46.52530 -8.78651  1.000 30.39760  ? 61  SER A CA  1 
ATOM   447  C C   . SER A 1 61  ? -48.90316 45.59549 -7.65919  1.000 28.53760  ? 61  SER A C   1 
ATOM   448  O O   . SER A 1 61  ? -47.70748 45.37460 -7.43872  1.000 23.32760  ? 61  SER A O   1 
ATOM   449  C CB  . SER A 1 61  ? -50.10753 45.73663 -9.83129  1.000 29.47760  ? 61  SER A CB  1 
ATOM   450  O OG  . SER A 1 61  ? -49.25354 44.75726 -10.38296 1.000 31.13760  ? 61  SER A OG  1 
ATOM   451  N N   . ILE A 1 62  ? -49.89842 45.04449 -6.95215  1.000 22.42912  ? 62  ILE A N   1 
ATOM   452  C CA  . ILE A 1 62  ? -49.64554 43.96926 -5.99038  1.000 24.57912  ? 62  ILE A CA  1 
ATOM   453  C C   . ILE A 1 62  ? -48.99469 42.78254 -6.68773  1.000 25.70912  ? 62  ILE A C   1 
ATOM   454  O O   . ILE A 1 62  ? -48.01616 42.20815 -6.19401  1.000 17.68912  ? 62  ILE A O   1 
ATOM   455  C CB  . ILE A 1 62  ? -50.95351 43.53702 -5.30288  1.000 23.93912  ? 62  ILE A CB  1 
ATOM   456  C CG1 . ILE A 1 62  ? -51.47777 44.60896 -4.35647  1.000 27.96912  ? 62  ILE A CG1 1 
ATOM   457  C CG2 . ILE A 1 62  ? -50.76050 42.24703 -4.53151  1.000 26.25912  ? 62  ILE A CG2 1 
ATOM   458  C CD1 . ILE A 1 62  ? -52.85243 44.29894 -3.84261  1.000 29.22912  ? 62  ILE A CD1 1 
ATOM   459  N N   . ILE A 1 63  ? -49.54680 42.39452 -7.84444  1.000 21.99885  ? 63  ILE A N   1 
ATOM   460  C CA  . ILE A 1 63  ? -49.03954 41.24507 -8.60079  1.000 27.67885  ? 63  ILE A CA  1 
ATOM   461  C C   . ILE A 1 63  ? -47.57587 41.44771 -8.98145  1.000 25.99885  ? 63  ILE A C   1 
ATOM   462  O O   . ILE A 1 63  ? -46.74110 40.55359 -8.79315  1.000 25.09885  ? 63  ILE A O   1 
ATOM   463  C CB  . ILE A 1 63  ? -49.91489 41.00046 -9.84544  1.000 37.42885  ? 63  ILE A CB  1 
ATOM   464  C CG1 . ILE A 1 63  ? -51.33284 40.57476 -9.44632  1.000 40.78885  ? 63  ILE A CG1 1 
ATOM   465  C CG2 . ILE A 1 63  ? -49.27280 39.97525 -10.76937 1.000 41.45885  ? 63  ILE A CG2 1 
ATOM   466  C CD1 . ILE A 1 63  ? -51.40967 39.22433 -8.77119  1.000 46.25885  ? 63  ILE A CD1 1 
ATOM   467  N N   . HIS A 1 64  ? -47.23837 42.63691 -9.49117  1.000 24.15350  ? 64  HIS A N   1 
ATOM   468  C CA  . HIS A 1 64  ? -45.85351 42.93316 -9.85961  1.000 29.43350  ? 64  HIS A CA  1 
ATOM   469  C C   . HIS A 1 64  ? -44.93769 43.00486 -8.63898  1.000 21.40350  ? 64  HIS A C   1 
ATOM   470  O O   . HIS A 1 64  ? -43.80132 42.50690 -8.67665  1.000 18.66350  ? 64  HIS A O   1 
ATOM   471  C CB  . HIS A 1 64  ? -45.78063 44.25510 -10.62185 1.000 33.48350  ? 64  HIS A CB  1 
ATOM   472  C CG  . HIS A 1 64  ? -46.15822 44.14604 -12.06493 1.000 46.23350  ? 64  HIS A CG  1 
ATOM   473  N ND1 . HIS A 1 64  ? -47.33148 43.55840 -12.48773 1.000 55.07350  ? 64  HIS A ND1 1 
ATOM   474  C CD2 . HIS A 1 64  ? -45.52132 44.56426 -13.18324 1.000 50.79350  ? 64  HIS A CD2 1 
ATOM   475  C CE1 . HIS A 1 64  ? -47.39681 43.61249 -13.80604 1.000 54.68350  ? 64  HIS A CE1 1 
ATOM   476  N NE2 . HIS A 1 64  ? -46.31181 44.21977 -14.25216 1.000 55.59350  ? 64  HIS A NE2 1 
ATOM   477  N N   . ALA A 1 65  ? -45.38809 43.68393 -7.57892  1.000 16.89771  ? 65  ALA A N   1 
ATOM   478  C CA  . ALA A 1 65  ? -44.56446 43.84547 -6.38253  1.000 15.80771  ? 65  ALA A CA  1 
ATOM   479  C C   . ALA A 1 65  ? -44.24752 42.49753 -5.74245  1.000 14.92771  ? 65  ALA A C   1 
ATOM   480  O O   . ALA A 1 65  ? -43.10984 42.24381 -5.33186  1.000 17.50771  ? 65  ALA A O   1 
ATOM   481  C CB  . ALA A 1 65  ? -45.26919 44.77188 -5.38957  1.000 17.45771  ? 65  ALA A CB  1 
ATOM   482  N N   . LYS A 1 66  ? -45.22787 41.60402 -5.68945  1.000 13.89083  ? 66  LYS A N   1 
ATOM   483  C CA  . LYS A 1 66  ? -44.98390 40.28007 -5.13418  1.000 16.19083  ? 66  LYS A CA  1 
ATOM   484  C C   . LYS A 1 66  ? -44.08124 39.45253 -6.03981  1.000 17.73083  ? 66  LYS A C   1 
ATOM   485  O O   . LYS A 1 66  ? -43.30420 38.61732 -5.55592  1.000 15.02083  ? 66  LYS A O   1 
ATOM   486  C CB  . LYS A 1 66  ? -46.31687 39.57502 -4.91274  1.000 16.62083  ? 66  LYS A CB  1 
ATOM   487  C CG  . LYS A 1 66  ? -46.20271 38.21714 -4.28562  1.000 15.35083  ? 66  LYS A CG  1 
ATOM   488  C CD  . LYS A 1 66  ? -47.57809 37.63091 -4.01265  1.000 18.58083  ? 66  LYS A CD  1 
ATOM   489  C CE  . LYS A 1 66  ? -47.45086 36.29130 -3.28276  1.000 22.98083  ? 66  LYS A CE  1 
ATOM   490  N NZ  . LYS A 1 66  ? -48.76404 35.61484 -3.00756  1.000 29.51083  ? 66  LYS A NZ  1 
ATOM   491  N N   . ARG A 1 67  ? -44.19039 39.65032 -7.35620  1.000 17.33800  ? 67  ARG A N   1 
ATOM   492  C CA  . ARG A 1 67  ? -43.35483 38.90715 -8.29824  1.000 17.95800  ? 67  ARG A CA  1 
ATOM   493  C C   . ARG A 1 67  ? -41.90727 39.35985 -8.20344  1.000 14.32800  ? 67  ARG A C   1 
ATOM   494  O O   . ARG A 1 67  ? -40.98562 38.54803 -8.32467  1.000 12.93800  ? 67  ARG A O   1 
ATOM   495  C CB  . ARG A 1 67  ? -43.88695 39.09035 -9.72665  1.000 23.63800  ? 67  ARG A CB  1 
ATOM   496  C CG  . ARG A 1 67  ? -42.94398 38.62549 -10.83935 1.000 36.48800  ? 67  ARG A CG  1 
ATOM   497  C CD  . ARG A 1 67  ? -43.49931 38.98133 -12.20548 1.000 44.14800  ? 67  ARG A CD  1 
ATOM   498  N NE  . ARG A 1 67  ? -44.79597 38.35030 -12.42512 1.000 63.26800  ? 67  ARG A NE  1 
ATOM   499  C CZ  . ARG A 1 67  ? -45.74521 38.83653 -13.21464 1.000 64.65800  ? 67  ARG A CZ  1 
ATOM   500  N NH1 . ARG A 1 67  ? -45.59779 39.99337 -13.84311 1.000 60.59800  ? 67  ARG A NH1 1 
ATOM   501  N NH2 . ARG A 1 67  ? -46.87181 38.14668 -13.37469 1.000 61.41800  ? 67  ARG A NH2 1 
ATOM   502  N N   . THR A 1 68  ? -41.69702 40.65540 -7.97835  1.000 13.63212  ? 68  THR A N   1 
ATOM   503  C CA  . THR A 1 68  ? -40.35443 41.17973 -7.76483  1.000 14.30212  ? 68  THR A CA  1 
ATOM   504  C C   . THR A 1 68  ? -39.73087 40.57993 -6.51488  1.000 14.31212  ? 68  THR A C   1 
ATOM   505  O O   . THR A 1 68  ? -38.55803 40.18475 -6.52388  1.000 12.87212  ? 68  THR A O   1 
ATOM   506  C CB  . THR A 1 68  ? -40.42091 42.70108 -7.65032  1.000 15.18212  ? 68  THR A CB  1 
ATOM   507  O OG1 . THR A 1 68  ? -40.93190 43.23472 -8.88466  1.000 15.64212  ? 68  THR A OG1 1 
ATOM   508  C CG2 . THR A 1 68  ? -39.06722 43.29350 -7.35255  1.000 15.08212  ? 68  THR A CG2 1 
ATOM   509  N N   . TYR A 1 69  ? -40.51870 40.48166 -5.43981  1.000 14.47400  ? 69  TYR A N   1 
ATOM   510  C CA  . TYR A 1 69  ? -40.03334 39.91647 -4.18403  1.000 14.07400  ? 69  TYR A CA  1 
ATOM   511  C C   . TYR A 1 69  ? -39.70395 38.43827 -4.34549  1.000 13.17400  ? 69  TYR A C   1 
ATOM   512  O O   . TYR A 1 69  ? -38.64399 37.97449 -3.91260  1.000 12.62400  ? 69  TYR A O   1 
ATOM   513  C CB  . TYR A 1 69  ? -41.09340 40.12562 -3.09824  1.000 12.92400  ? 69  TYR A CB  1 
ATOM   514  C CG  . TYR A 1 69  ? -40.74517 39.49096 -1.78007  1.000 11.93400  ? 69  TYR A CG  1 
ATOM   515  C CD1 . TYR A 1 69  ? -39.80191 40.07054 -0.93389  1.000 13.43400  ? 69  TYR A CD1 1 
ATOM   516  C CD2 . TYR A 1 69  ? -41.35413 38.31046 -1.37611  1.000 13.26400  ? 69  TYR A CD2 1 
ATOM   517  C CE1 . TYR A 1 69  ? -39.47797 39.48129 0.27537   1.000 13.21400  ? 69  TYR A CE1 1 
ATOM   518  C CE2 . TYR A 1 69  ? -41.03978 37.71966 -0.15800  1.000 14.86400  ? 69  TYR A CE2 1 
ATOM   519  C CZ  . TYR A 1 69  ? -40.10420 38.30619 0.65509   1.000 14.02400  ? 69  TYR A CZ  1 
ATOM   520  O OH  . TYR A 1 69  ? -39.79948 37.71130 1.86811   1.000 14.63400  ? 69  TYR A OH  1 
ATOM   521  N N   . ARG A 1 70  ? -40.60552 37.68754 -4.98529  1.000 11.96341  ? 70  ARG A N   1 
ATOM   522  C CA  . ARG A 1 70  ? -40.37446 36.26995 -5.25048  1.000 13.85341  ? 70  ARG A CA  1 
ATOM   523  C C   . ARG A 1 70  ? -39.10311 36.03593 -6.06096  1.000 14.85341  ? 70  ARG A C   1 
ATOM   524  O O   . ARG A 1 70  ? -38.33121 35.12480 -5.74581  1.000 15.26341  ? 70  ARG A O   1 
ATOM   525  C CB  . ARG A 1 70  ? -41.57824 35.68062 -5.98685  1.000 15.54341  ? 70  ARG A CB  1 
ATOM   526  C CG  . ARG A 1 70  ? -41.40234 34.25897 -6.48489  1.000 18.06341  ? 70  ARG A CG  1 
ATOM   527  C CD  . ARG A 1 70  ? -42.52483 33.89815 -7.47339  1.000 23.17341  ? 70  ARG A CD  1 
ATOM   528  N NE  . ARG A 1 70  ? -43.83907 33.90237 -6.83952  1.000 21.83341  ? 70  ARG A NE  1 
ATOM   529  C CZ  . ARG A 1 70  ? -44.82332 34.74280 -7.14257  1.000 23.33341  ? 70  ARG A CZ  1 
ATOM   530  N NH1 . ARG A 1 70  ? -44.71784 35.59915 -8.14109  1.000 25.78341  ? 70  ARG A NH1 1 
ATOM   531  N NH2 . ARG A 1 70  ? -45.93588 34.73234 -6.41277  1.000 24.23341  ? 70  ARG A NH2 1 
ATOM   532  N N   . GLU A 1 71  ? -38.87313 36.83788 -7.10961  1.000 14.78560  ? 71  GLU A N   1 
ATOM   533  C CA  . GLU A 1 71  ? -37.67356 36.65758 -7.93084  1.000 16.82560  ? 71  GLU A CA  1 
ATOM   534  C C   . GLU A 1 71  ? -36.41310 36.94627 -7.13113  1.000 14.87560  ? 71  GLU A C   1 
ATOM   535  O O   . GLU A 1 71  ? -35.43811 36.19058 -7.20412  1.000 13.95560  ? 71  GLU A O   1 
ATOM   536  C CB  . GLU A 1 71  ? -37.71926 37.55269 -9.17695  1.000 21.80560  ? 71  GLU A CB  1 
ATOM   537  C CG  . GLU A 1 71  ? -36.38117 37.56219 -9.95403  1.000 26.49560  ? 71  GLU A CG  1 
ATOM   538  C CD  . GLU A 1 71  ? -36.43408 38.24141 -11.32240 1.000 32.93560  ? 71  GLU A CD  1 
ATOM   539  O OE1 . GLU A 1 71  ? -37.38293 39.01230 -11.58750 1.000 37.67560  ? 71  GLU A OE1 1 
ATOM   540  O OE2 . GLU A 1 71  ? -35.50479 38.00311 -12.13707 1.000 37.38560  ? 71  GLU A OE2 1 
ATOM   541  N N   . LEU A 1 72  ? -36.43279 38.00379 -6.31619  1.000 12.54281  ? 72  LEU A N   1 
ATOM   542  C CA  . LEU A 1 72  ? -35.24739 38.34150 -5.53794  1.000 12.93281  ? 72  LEU A CA  1 
ATOM   543  C C   . LEU A 1 72  ? -34.98881 37.31606 -4.44148  1.000 11.90281  ? 72  LEU A C   1 
ATOM   544  O O   . LEU A 1 72  ? -33.83807 36.93174 -4.21567  1.000 11.75281  ? 72  LEU A O   1 
ATOM   545  C CB  . LEU A 1 72  ? -35.37960 39.75239 -4.96953  1.000 13.86281  ? 72  LEU A CB  1 
ATOM   546  C CG  . LEU A 1 72  ? -34.20498 40.32874 -4.18065  1.000 17.30281  ? 72  LEU A CG  1 
ATOM   547  C CD1 . LEU A 1 72  ? -32.86498 40.28600 -4.96133  1.000 18.92281  ? 72  LEU A CD1 1 
ATOM   548  C CD2 . LEU A 1 72  ? -34.53797 41.73542 -3.76863  1.000 16.75281  ? 72  LEU A CD2 1 
ATOM   549  N N   . ARG A 1 73  ? -36.04077 36.85913 -3.75208  1.000 11.48870  ? 73  ARG A N   1 
ATOM   550  C CA  . ARG A 1 73  ? -35.88183 35.78577 -2.77519  1.000 12.03870  ? 73  ARG A CA  1 
ATOM   551  C C   . ARG A 1 73  ? -35.26692 34.54217 -3.42094  1.000 13.40870  ? 73  ARG A C   1 
ATOM   552  O O   . ARG A 1 73  ? -34.31006 33.96245 -2.89129  1.000 11.74870  ? 73  ARG A O   1 
ATOM   553  C CB  . ARG A 1 73  ? -37.23648 35.45571 -2.14419  1.000 12.62870  ? 73  ARG A CB  1 
ATOM   554  C CG  . ARG A 1 73  ? -37.65671 36.40653 -1.00025  1.000 12.87870  ? 73  ARG A CG  1 
ATOM   555  C CD  . ARG A 1 73  ? -36.81475 36.21985 0.28702   1.000 12.03870  ? 73  ARG A CD  1 
ATOM   556  N NE  . ARG A 1 73  ? -36.78848 34.84301 0.77783   1.000 12.27870  ? 73  ARG A NE  1 
ATOM   557  C CZ  . ARG A 1 73  ? -37.78621 34.22017 1.40872   1.000 16.10870  ? 73  ARG A CZ  1 
ATOM   558  N NH1 . ARG A 1 73  ? -38.91690 34.83980 1.71746   1.000 14.88870  ? 73  ARG A NH1 1 
ATOM   559  N NH2 . ARG A 1 73  ? -37.65146 32.93243 1.73113   1.000 16.29870  ? 73  ARG A NH2 1 
ATOM   560  N N   . LEU A 1 74  ? -35.78676 34.14666 -4.58733  1.000 12.88916  ? 74  LEU A N   1 
ATOM   561  C CA  . LEU A 1 74  ? -35.27540 32.96310 -5.28441  1.000 13.55916  ? 74  LEU A CA  1 
ATOM   562  C C   . LEU A 1 74  ? -33.81315 33.14549 -5.69097  1.000 12.57916  ? 74  LEU A C   1 
ATOM   563  O O   . LEU A 1 74  ? -32.95908 32.30991 -5.37173  1.000 12.31916  ? 74  LEU A O   1 
ATOM   564  C CB  . LEU A 1 74  ? -36.14625 32.67653 -6.50544  1.000 17.55916  ? 74  LEU A CB  1 
ATOM   565  C CG  . LEU A 1 74  ? -35.90104 31.32520 -7.16683  1.000 25.62916  ? 74  LEU A CG  1 
ATOM   566  C CD1 . LEU A 1 74  ? -36.36480 30.26263 -6.22050  1.000 29.72916  ? 74  LEU A CD1 1 
ATOM   567  C CD2 . LEU A 1 74  ? -36.66046 31.23056 -8.47006  1.000 33.12916  ? 74  LEU A CD2 1 
ATOM   568  N N   . LEU A 1 75  ? -33.49548 34.25308 -6.36207  1.000 13.02292  ? 75  LEU A N   1 
ATOM   569  C CA  . LEU A 1 75  ? -32.11831 34.46662 -6.81846  1.000 13.95292  ? 75  LEU A CA  1 
ATOM   570  C C   . LEU A 1 75  ? -31.13102 34.60060 -5.66505  1.000 14.76292  ? 75  LEU A C   1 
ATOM   571  O O   . LEU A 1 75  ? -29.97872 34.17066 -5.79535  1.000 13.81292  ? 75  LEU A O   1 
ATOM   572  C CB  . LEU A 1 75  ? -32.04306 35.70508 -7.70136  1.000 16.89292  ? 75  LEU A CB  1 
ATOM   573  C CG  . LEU A 1 75  ? -32.69990 35.55020 -9.07368  1.000 22.36292  ? 75  LEU A CG  1 
ATOM   574  C CD1 . LEU A 1 75  ? -32.74739 36.90172 -9.77259  1.000 24.11292  ? 75  LEU A CD1 1 
ATOM   575  C CD2 . LEU A 1 75  ? -31.93832 34.52007 -9.91050  1.000 26.47292  ? 75  LEU A CD2 1 
ATOM   576  N N   . LYS A 1 76  ? -31.55516 35.17903 -4.53019  1.000 14.20772  ? 76  LYS A N   1 
ATOM   577  C CA  . LYS A 1 76  ? -30.66329 35.26335 -3.37450  1.000 15.35772  ? 76  LYS A CA  1 
ATOM   578  C C   . LYS A 1 76  ? -30.37882 33.89471 -2.76433  1.000 14.42772  ? 76  LYS A C   1 
ATOM   579  O O   . LYS A 1 76  ? -29.33756 33.70736 -2.13258  1.000 14.35772  ? 76  LYS A O   1 
ATOM   580  C CB  . LYS A 1 76  ? -31.26114 36.19059 -2.30345  1.000 15.99772  ? 76  LYS A CB  1 
ATOM   581  C CG  . LYS A 1 76  ? -31.09553 37.67740 -2.63691  1.000 17.56772  ? 76  LYS A CG  1 
ATOM   582  C CD  . LYS A 1 76  ? -31.64327 38.58553 -1.54957  1.000 17.13772  ? 76  LYS A CD  1 
ATOM   583  C CE  . LYS A 1 76  ? -30.89908 38.40301 -0.23853  1.000 16.18772  ? 76  LYS A CE  1 
ATOM   584  N NZ  . LYS A 1 76  ? -31.24227 39.47612 0.74295   1.000 15.53772  ? 76  LYS A NZ  1 
ATOM   585  N N   . HIS A 1 77  ? -31.27825 32.93090 -2.93875  1.000 13.04480  ? 77  HIS A N   1 
ATOM   586  C CA  . HIS A 1 77  ? -31.09711 31.63291 -2.30777  1.000 14.93480  ? 77  HIS A CA  1 
ATOM   587  C C   . HIS A 1 77  ? -30.13361 30.72030 -3.07054  1.000 15.38480  ? 77  HIS A C   1 
ATOM   588  O O   . HIS A 1 77  ? -29.47784 29.88778 -2.44196  1.000 14.75480  ? 77  HIS A O   1 
ATOM   589  C CB  . HIS A 1 77  ? -32.44861 30.94276 -2.15827  1.000 15.47480  ? 77  HIS A CB  1 
ATOM   590  C CG  . HIS A 1 77  ? -32.41258 29.72890 -1.28339  1.000 17.21480  ? 77  HIS A CG  1 
ATOM   591  N ND1 . HIS A 1 77  ? -32.47130 29.80231 0.09125   1.000 18.59480  ? 77  HIS A ND1 1 
ATOM   592  C CD2 . HIS A 1 77  ? -32.32001 28.41086 -1.58545  1.000 17.85480  ? 77  HIS A CD2 1 
ATOM   593  C CE1 . HIS A 1 77  ? -32.41541 28.58589 0.60194   1.000 20.77480  ? 77  HIS A CE1 1 
ATOM   594  N NE2 . HIS A 1 77  ? -32.32807 27.72161 -0.39413  1.000 20.08480  ? 77  HIS A NE2 1 
ATOM   595  N N   . MET A 1 78  ? -30.04802 30.84957 -4.39779  1.000 15.47290  ? 78  MET A N   1 
ATOM   596  C CA  . MET A 1 78  ? -29.33425 29.90112 -5.26552  1.000 17.89290  ? 78  MET A CA  1 
ATOM   597  C C   . MET A 1 78  ? -27.83692 30.08672 -5.14407  1.000 15.59290  ? 78  MET A C   1 
ATOM   598  O O   . MET A 1 78  ? -27.30319 31.08061 -5.63509  1.000 15.93290  ? 78  MET A O   1 
ATOM   599  C CB  . MET A 1 78  ? -29.67641 30.12486 -6.73410  1.000 21.01290  ? 78  MET A CB  1 
ATOM   600  C CG  . MET A 1 78  ? -31.09852 30.07068 -7.04472  1.000 23.99290  ? 78  MET A CG  1 
ATOM   601  S SD  . MET A 1 78  ? -31.66666 28.43379 -6.70887  1.000 30.82290  ? 78  MET A SD  1 
ATOM   602  C CE  . MET A 1 78  ? -33.24904 28.62208 -7.48758  1.000 30.40290  ? 78  MET A CE  1 
ATOM   603  N N   . LYS A 1 79  ? -27.13190 29.10882 -4.58069  1.000 13.49580  ? 79  LYS A N   1 
ATOM   604  C CA  . LYS A 1 79  ? -25.67465 29.19461 -4.47406  1.000 15.99580  ? 79  LYS A CA  1 
ATOM   605  C C   . LYS A 1 79  ? -25.08799 27.85787 -4.91206  1.000 11.76580  ? 79  LYS A C   1 
ATOM   606  O O   . LYS A 1 79  ? -24.80008 26.99386 -4.08272  1.000 11.30580  ? 79  LYS A O   1 
ATOM   607  C CB  . LYS A 1 79  ? -25.25721 29.57793 -3.04787  1.000 19.73580  ? 79  LYS A CB  1 
ATOM   608  C CG  . LYS A 1 79  ? -25.74007 30.97734 -2.62630  1.000 24.49580  ? 79  LYS A CG  1 
ATOM   609  C CD  . LYS A 1 79  ? -25.59985 31.17990 -1.13079  1.000 30.21580  ? 79  LYS A CD  1 
ATOM   610  C CE  . LYS A 1 79  ? -26.05726 32.57521 -0.71475  1.000 39.42580  ? 79  LYS A CE  1 
ATOM   611  N NZ  . LYS A 1 79  ? -25.88416 32.80033 0.75771   1.000 45.71580  ? 79  LYS A NZ  1 
ATOM   612  N N   . HIS A 1 80  ? -24.90775 27.69663 -6.22444  1.000 12.79277  ? 80  HIS A N   1 
ATOM   613  C CA  . HIS A 1 80  ? -24.50657 26.41340 -6.79074  1.000 14.77277  ? 80  HIS A CA  1 
ATOM   614  C C   . HIS A 1 80  ? -23.81716 26.65650 -8.13056  1.000 13.15277  ? 80  HIS A C   1 
ATOM   615  O O   . HIS A 1 80  ? -24.21130 27.55096 -8.87704  1.000 12.99277  ? 80  HIS A O   1 
ATOM   616  C CB  . HIS A 1 80  ? -25.72088 25.48658 -6.97110  1.000 15.11277  ? 80  HIS A CB  1 
ATOM   617  C CG  . HIS A 1 80  ? -25.36817 24.09919 -7.41999  1.000 13.28277  ? 80  HIS A CG  1 
ATOM   618  N ND1 . HIS A 1 80  ? -25.11346 23.78628 -8.73794  1.000 14.33277  ? 80  HIS A ND1 1 
ATOM   619  C CD2 . HIS A 1 80  ? -25.22844 22.94277 -6.72583  1.000 15.19277  ? 80  HIS A CD2 1 
ATOM   620  C CE1 . HIS A 1 80  ? -24.84029 22.49639 -8.83877  1.000 14.39277  ? 80  HIS A CE1 1 
ATOM   621  N NE2 . HIS A 1 80  ? -24.90272 21.96135 -7.63181  1.000 13.32277  ? 80  HIS A NE2 1 
ATOM   622  N N   . GLU A 1 81  ? -22.79194 25.84751 -8.42276  1.000 15.01311  ? 81  GLU A N   1 
ATOM   623  C CA  . GLU A 1 81  ? -21.95002 26.04632 -9.61122  1.000 17.55311  ? 81  GLU A CA  1 
ATOM   624  C C   . GLU A 1 81  ? -22.71924 25.90209 -10.92551 1.000 13.41311  ? 81  GLU A C   1 
ATOM   625  O O   . GLU A 1 81  ? -22.32318 26.48561 -11.93964 1.000 13.20311  ? 81  GLU A O   1 
ATOM   626  C CB  . GLU A 1 81  ? -20.79049 25.04111 -9.62189  1.000 25.31311  ? 81  GLU A CB  1 
ATOM   627  C CG  . GLU A 1 81  ? -19.84606 25.11557 -8.42267  1.000 35.74311  ? 81  GLU A CG  1 
ATOM   628  C CD  . GLU A 1 81  ? -18.93339 23.88649 -8.30579  1.000 50.08311  ? 81  GLU A CD  1 
ATOM   629  O OE1 . GLU A 1 81  ? -18.94965 23.01658 -9.21513  1.000 48.89311  ? 81  GLU A OE1 1 
ATOM   630  O OE2 . GLU A 1 81  ? -18.19928 23.79460 -7.29619  1.000 67.00311  ? 81  GLU A OE2 1 
ATOM   631  N N   . ASN A 1 82  ? -23.78880 25.11329 -10.94780 1.000 11.68798  ? 82  ASN A N   1 
ATOM   632  C CA  . ASN A 1 82  ? -24.54873 24.87785 -12.17206 1.000 11.81798  ? 82  ASN A CA  1 
ATOM   633  C C   . ASN A 1 82  ? -25.86785 25.63876 -12.19825 1.000 12.49798  ? 82  ASN A C   1 
ATOM   634  O O   . ASN A 1 82  ? -26.75583 25.31501 -13.00284 1.000 11.59798  ? 82  ASN A O   1 
ATOM   635  C CB  . ASN A 1 82  ? -24.78271 23.37975 -12.34219 1.000 10.56798  ? 82  ASN A CB  1 
ATOM   636  C CG  . ASN A 1 82  ? -23.48485 22.61576 -12.39893 1.000 11.06798  ? 82  ASN A CG  1 
ATOM   637  O OD1 . ASN A 1 82  ? -23.22689 21.75176 -11.56810 1.000 13.34798  ? 82  ASN A OD1 1 
ATOM   638  N ND2 . ASN A 1 82  ? -22.64962 22.93312 -13.38881 1.000 12.95798  ? 82  ASN A ND2 1 
ATOM   639  N N   . VAL A 1 83  ? -26.02420 26.64101 -11.32419 1.000 10.59944  ? 83  VAL A N   1 
ATOM   640  C CA  . VAL A 1 83  ? -27.23761 27.44994 -11.26932 1.000 11.39944  ? 83  VAL A CA  1 
ATOM   641  C C   . VAL A 1 83  ? -26.83732 28.92115 -11.29355 1.000 13.41944  ? 83  VAL A C   1 
ATOM   642  O O   . VAL A 1 83  ? -25.84526 29.30811 -10.65917 1.000 14.31944  ? 83  VAL A O   1 
ATOM   643  C CB  . VAL A 1 83  ? -28.07352 27.13570 -10.00465 1.000 11.78944  ? 83  VAL A CB  1 
ATOM   644  C CG1 . VAL A 1 83  ? -29.37297 27.95065 -9.98512  1.000 13.09944  ? 83  VAL A CG1 1 
ATOM   645  C CG2 . VAL A 1 83  ? -28.37477 25.63869 -9.91052  1.000 12.45944  ? 83  VAL A CG2 1 
ATOM   646  N N   . ILE A 1 84  ? -27.59197 29.73030 -12.04859 1.000 11.96806  ? 84  ILE A N   1 
ATOM   647  C CA  . ILE A 1 84  ? -27.34629 31.16537 -12.08144 1.000 19.06806  ? 84  ILE A CA  1 
ATOM   648  C C   . ILE A 1 84  ? -27.44490 31.72916 -10.66860 1.000 16.12806  ? 84  ILE A C   1 
ATOM   649  O O   . ILE A 1 84  ? -28.25471 31.27848 -9.84732  1.000 16.60806  ? 84  ILE A O   1 
ATOM   650  C CB  . ILE A 1 84  ? -28.32453 31.84975 -13.05587 1.000 26.77806  ? 84  ILE A CB  1 
ATOM   651  C CG1 . ILE A 1 84  ? -27.83513 33.25233 -13.41040 1.000 33.59806  ? 84  ILE A CG1 1 
ATOM   652  C CG2 . ILE A 1 84  ? -29.78001 31.85379 -12.52251 1.000 28.43806  ? 84  ILE A CG2 1 
ATOM   653  C CD1 . ILE A 1 84  ? -26.53914 33.24875 -14.23142 1.000 36.14806  ? 84  ILE A CD1 1 
ATOM   654  N N   . GLY A 1 85  ? -26.53098 32.63751 -10.34687 1.000 19.05016  ? 85  GLY A N   1 
ATOM   655  C CA  . GLY A 1 85  ? -26.46883 33.21512 -9.02607  1.000 22.44016  ? 85  GLY A CA  1 
ATOM   656  C C   . GLY A 1 85  ? -26.47455 34.73119 -9.10205  1.000 19.97016  ? 85  GLY A C   1 
ATOM   657  O O   . GLY A 1 85  ? -26.15079 35.33073 -10.12155 1.000 20.94016  ? 85  GLY A O   1 
ATOM   658  N N   . LEU A 1 86  ? -26.88209 35.33812 -8.00491  1.000 17.51712  ? 86  LEU A N   1 
ATOM   659  C CA  . LEU A 1 86  ? -27.00112 36.78806 -7.94440  1.000 16.60712  ? 86  LEU A CA  1 
ATOM   660  C C   . LEU A 1 86  ? -25.62367 37.33155 -7.59272  1.000 13.92712  ? 86  LEU A C   1 
ATOM   661  O O   . LEU A 1 86  ? -25.13282 37.10824 -6.47993  1.000 17.89712  ? 86  LEU A O   1 
ATOM   662  C CB  . LEU A 1 86  ? -28.04560 37.18251 -6.90771  1.000 17.09712  ? 86  LEU A CB  1 
ATOM   663  C CG  . LEU A 1 86  ? -28.59888 38.59733 -6.91626  1.000 19.50712  ? 86  LEU A CG  1 
ATOM   664  C CD1 . LEU A 1 86  ? -29.29064 38.91979 -8.22364  1.000 19.28712  ? 86  LEU A CD1 1 
ATOM   665  C CD2 . LEU A 1 86  ? -29.54352 38.76344 -5.75940  1.000 20.37712  ? 86  LEU A CD2 1 
ATOM   666  N N   . LEU A 1 87  ? -24.98456 38.01409 -8.53889  1.000 17.88045  ? 87  LEU A N   1 
ATOM   667  C CA  . LEU A 1 87  ? -23.71866 38.67290 -8.22868  1.000 18.78045  ? 87  LEU A CA  1 
ATOM   668  C C   . LEU A 1 87  ? -23.91333 39.94843 -7.41714  1.000 18.25045  ? 87  LEU A C   1 
ATOM   669  O O   . LEU A 1 87  ? -23.05598 40.29693 -6.59021  1.000 16.59045  ? 87  LEU A O   1 
ATOM   670  C CB  . LEU A 1 87  ? -22.97079 39.00866 -9.52318  1.000 23.46045  ? 87  LEU A CB  1 
ATOM   671  C CG  . LEU A 1 87  ? -22.55400 37.80089 -10.36622 1.000 32.81045  ? 87  LEU A CG  1 
ATOM   672  C CD1 . LEU A 1 87  ? -21.64869 38.25811 -11.50292 1.000 35.86045  ? 87  LEU A CD1 1 
ATOM   673  C CD2 . LEU A 1 87  ? -21.86149 36.76209 -9.50629  1.000 36.17045  ? 87  LEU A CD2 1 
ATOM   674  N N   . ASP A 1 88  ? -25.00382 40.66550 -7.65950  1.000 17.43371  ? 88  ASP A N   1 
ATOM   675  C CA  . ASP A 1 88  ? -25.25100 41.95115 -7.02426  1.000 16.47371  ? 88  ASP A CA  1 
ATOM   676  C C   . ASP A 1 88  ? -26.71371 42.29152 -7.26498  1.000 14.27371  ? 88  ASP A C   1 
ATOM   677  O O   . ASP A 1 88  ? -27.29892 41.88082 -8.26769  1.000 12.76371  ? 88  ASP A O   1 
ATOM   678  C CB  . ASP A 1 88  ? -24.33302 43.04074 -7.61354  1.000 16.41371  ? 88  ASP A CB  1 
ATOM   679  C CG  . ASP A 1 88  ? -24.23597 44.30633 -6.74987  1.000 21.08371  ? 88  ASP A CG  1 
ATOM   680  O OD1 . ASP A 1 88  ? -24.66753 44.30262 -5.56966  1.000 19.78371  ? 88  ASP A OD1 1 
ATOM   681  O OD2 . ASP A 1 88  ? -23.72083 45.32568 -7.28277  1.000 21.71371  ? 88  ASP A OD2 1 
ATOM   682  N N   . VAL A 1 89  ? -27.29315 43.04710 -6.33775  1.000 14.97221  ? 89  VAL A N   1 
ATOM   683  C CA  . VAL A 1 89  ? -28.58530 43.68223 -6.53974  1.000 13.38221  ? 89  VAL A CA  1 
ATOM   684  C C   . VAL A 1 89  ? -28.46481 45.06812 -5.92772  1.000 14.20221  ? 89  VAL A C   1 
ATOM   685  O O   . VAL A 1 89  ? -27.85272 45.22544 -4.86674  1.000 13.19221  ? 89  VAL A O   1 
ATOM   686  C CB  . VAL A 1 89  ? -29.74138 42.86012 -5.92036  1.000 16.18221  ? 89  VAL A CB  1 
ATOM   687  C CG1 . VAL A 1 89  ? -29.43245 42.46629 -4.48674  1.000 19.07221  ? 89  VAL A CG1 1 
ATOM   688  C CG2 . VAL A 1 89  ? -31.07907 43.62349 -6.01153  1.000 16.94221  ? 89  VAL A CG2 1 
ATOM   689  N N   . PHE A 1 90  ? -28.97227 46.08267 -6.62887  1.000 12.50610  ? 90  PHE A N   1 
ATOM   690  C CA  . PHE A 1 90  ? -28.78959 47.44008 -6.13810  1.000 14.88610  ? 90  PHE A CA  1 
ATOM   691  C C   . PHE A 1 90  ? -29.96095 48.31490 -6.55892  1.000 13.89610  ? 90  PHE A C   1 
ATOM   692  O O   . PHE A 1 90  ? -30.69468 48.01305 -7.51420  1.000 15.54610  ? 90  PHE A O   1 
ATOM   693  C CB  . PHE A 1 90  ? -27.43895 48.04674 -6.62056  1.000 14.02610  ? 90  PHE A CB  1 
ATOM   694  C CG  . PHE A 1 90  ? -27.30492 48.16917 -8.12501  1.000 14.84610  ? 90  PHE A CG  1 
ATOM   695  C CD1 . PHE A 1 90  ? -27.85651 49.24407 -8.81695  1.000 15.59610  ? 90  PHE A CD1 1 
ATOM   696  C CD2 . PHE A 1 90  ? -26.58376 47.22747 -8.84747  1.000 16.81610  ? 90  PHE A CD2 1 
ATOM   697  C CE1 . PHE A 1 90  ? -27.73049 49.35595 -10.19445 1.000 17.02610  ? 90  PHE A CE1 1 
ATOM   698  C CE2 . PHE A 1 90  ? -26.44322 47.34774 -10.21851 1.000 15.28610  ? 90  PHE A CE2 1 
ATOM   699  C CZ  . PHE A 1 90  ? -27.00998 48.40521 -10.89644 1.000 15.82610  ? 90  PHE A CZ  1 
ATOM   700  N N   . THR A 1 91  ? -30.10110 49.42731 -5.84320  1.000 14.67632  ? 91  THR A N   1 
ATOM   701  C CA  . THR A 1 91  ? -30.98817 50.52014 -6.20774  1.000 17.53632  ? 91  THR A CA  1 
ATOM   702  C C   . THR A 1 91  ? -30.25743 51.83876 -6.00457  1.000 15.19632  ? 91  THR A C   1 
ATOM   703  O O   . THR A 1 91  ? -29.45662 51.96315 -5.07277  1.000 15.77632  ? 91  THR A O   1 
ATOM   704  C CB  . THR A 1 91  ? -32.28307 50.51286 -5.36873  1.000 20.39632  ? 91  THR A CB  1 
ATOM   705  O OG1 . THR A 1 91  ? -33.06689 51.67249 -5.68198  1.000 20.15632  ? 91  THR A OG1 1 
ATOM   706  C CG2 . THR A 1 91  ? -31.99093 50.47275 -3.86875  1.000 20.28632  ? 91  THR A CG2 1 
ATOM   707  N N   . PRO A 1 92  ? -30.51396 52.84315 -6.85112  1.000 16.42903  ? 92  PRO A N   1 
ATOM   708  C CA  . PRO A 1 92  ? -29.96851 54.18393 -6.56973  1.000 21.83903  ? 92  PRO A CA  1 
ATOM   709  C C   . PRO A 1 92  ? -30.63515 54.86949 -5.38178  1.000 22.75903  ? 92  PRO A C   1 
ATOM   710  O O   . PRO A 1 92  ? -30.09709 55.86648 -4.88756  1.000 24.26903  ? 92  PRO A O   1 
ATOM   711  C CB  . PRO A 1 92  ? -30.22055 54.95317 -7.87925  1.000 22.12903  ? 92  PRO A CB  1 
ATOM   712  C CG  . PRO A 1 92  ? -31.35118 54.25131 -8.53189  1.000 21.81903  ? 92  PRO A CG  1 
ATOM   713  C CD  . PRO A 1 92  ? -31.22742 52.79504 -8.14354  1.000 21.23903  ? 92  PRO A CD  1 
ATOM   714  N N   . ALA A 1 93  ? -31.74284 54.32797 -4.88009  1.000 21.94653  ? 93  ALA A N   1 
ATOM   715  C CA  . ALA A 1 93  ? -32.48298 54.95417 -3.79367  1.000 24.33653  ? 93  ALA A CA  1 
ATOM   716  C C   . ALA A 1 93  ? -31.69032 54.96791 -2.49860  1.000 25.88653  ? 93  ALA A C   1 
ATOM   717  O O   . ALA A 1 93  ? -31.06827 53.96984 -2.10951  1.000 22.77653  ? 93  ALA A O   1 
ATOM   718  C CB  . ALA A 1 93  ? -33.79957 54.21717 -3.56875  1.000 24.26653  ? 93  ALA A CB  1 
ATOM   719  N N   . ARG A 1 94  ? -31.73752 56.10681 -1.81104  1.000 26.41567  ? 94  ARG A N   1 
ATOM   720  C CA  . ARG A 1 94  ? -31.10041 56.21168 -0.51180  1.000 29.10567  ? 94  ARG A CA  1 
ATOM   721  C C   . ARG A 1 94  ? -32.02300 55.79440 0.62556   1.000 28.24567  ? 94  ARG A C   1 
ATOM   722  O O   . ARG A 1 94  ? -31.54981 55.63415 1.75522   1.000 35.60567  ? 94  ARG A O   1 
ATOM   723  C CB  . ARG A 1 94  ? -30.59267 57.64261 -0.29259  1.000 37.45567  ? 94  ARG A CB  1 
ATOM   724  C CG  . ARG A 1 94  ? -29.68971 58.14871 -1.41840  1.000 43.44567  ? 94  ARG A CG  1 
ATOM   725  C CD  . ARG A 1 94  ? -29.27681 59.59535 -1.19800  1.000 43.24567  ? 94  ARG A CD  1 
ATOM   726  N NE  . ARG A 1 94  ? -28.35918 60.08260 -2.22466  1.000 51.79567  ? 94  ARG A NE  1 
ATOM   727  C CZ  . ARG A 1 94  ? -27.03339 60.03950 -2.13861  1.000 57.11567  ? 94  ARG A CZ  1 
ATOM   728  N NH1 . ARG A 1 94  ? -26.42185 59.51095 -1.08662  1.000 51.10567  ? 94  ARG A NH1 1 
ATOM   729  N NH2 . ARG A 1 94  ? -26.30227 60.53854 -3.13408  1.000 56.11567  ? 94  ARG A NH2 1 
ATOM   730  N N   . SER A 1 95  ? -33.31095 55.58980 0.35152   1.000 30.37792  ? 95  SER A N   1 
ATOM   731  C CA  . SER A 1 95  ? -34.26326 55.20105 1.38437   1.000 29.85792  ? 95  SER A CA  1 
ATOM   732  C C   . SER A 1 95  ? -35.46569 54.53218 0.73338   1.000 25.08792  ? 95  SER A C   1 
ATOM   733  O O   . SER A 1 95  ? -35.63955 54.56989 -0.48634  1.000 26.62792  ? 95  SER A O   1 
ATOM   734  C CB  . SER A 1 95  ? -34.72591 56.41112 2.20243   1.000 32.09792  ? 95  SER A CB  1 
ATOM   735  O OG  . SER A 1 95  ? -35.59068 57.21477 1.41262   1.000 28.19792  ? 95  SER A OG  1 
ATOM   736  N N   . LEU A 1 96  ? -36.32172 53.95147 1.58679   1.000 24.14690  ? 96  LEU A N   1 
ATOM   737  C CA  . LEU A 1 96  ? -37.53817 53.29032 1.12267   1.000 24.68690  ? 96  LEU A CA  1 
ATOM   738  C C   . LEU A 1 96  ? -38.46011 54.25730 0.39225   1.000 27.68690  ? 96  LEU A C   1 
ATOM   739  O O   . LEU A 1 96  ? -39.12251 53.87230 -0.58189  1.000 23.11690  ? 96  LEU A O   1 
ATOM   740  C CB  . LEU A 1 96  ? -38.26324 52.64686 2.31534   1.000 24.88690  ? 96  LEU A CB  1 
ATOM   741  C CG  . LEU A 1 96  ? -39.59367 51.93755 2.03472   1.000 25.55690  ? 96  LEU A CG  1 
ATOM   742  C CD1 . LEU A 1 96  ? -39.39792 50.80107 1.04579   1.000 25.56690  ? 96  LEU A CD1 1 
ATOM   743  C CD2 . LEU A 1 96  ? -40.25586 51.42999 3.31163   1.000 25.44690  ? 96  LEU A CD2 1 
ATOM   744  N N   . GLU A 1 97  ? -38.47507 55.52579 0.81950   1.000 29.25018  ? 97  GLU A N   1 
ATOM   745  C CA  . GLU A 1 97  ? -39.40588 56.50964 0.26518   1.000 33.60018  ? 97  GLU A CA  1 
ATOM   746  C C   . GLU A 1 97  ? -39.14469 56.76498 -1.21258  1.000 30.32018  ? 97  GLU A C   1 
ATOM   747  O O   . GLU A 1 97  ? -40.08876 56.90383 -2.00017  1.000 35.91018  ? 97  GLU A O   1 
ATOM   748  C CB  . GLU A 1 97  ? -39.32053 57.81647 1.05771   1.000 38.30018  ? 97  GLU A CB  1 
ATOM   749  C CG  . GLU A 1 97  ? -39.94070 57.75624 2.46021   1.000 49.38018  ? 97  GLU A CG  1 
ATOM   750  C CD  . GLU A 1 97  ? -39.14830 56.89738 3.44119   1.000 56.35018  ? 97  GLU A CD  1 
ATOM   751  O OE1 . GLU A 1 97  ? -37.89984 56.91865 3.37510   1.000 64.17018  ? 97  GLU A OE1 1 
ATOM   752  O OE2 . GLU A 1 97  ? -39.77451 56.18231 4.25706   1.000 58.13018  ? 97  GLU A OE2 1 
ATOM   753  N N   . GLU A 1 98  ? -37.88017 56.80138 -1.62222  1.000 32.40646  ? 98  GLU A N   1 
ATOM   754  C CA  . GLU A 1 98  ? -37.57349 57.00274 -3.03158  1.000 35.24646  ? 98  GLU A CA  1 
ATOM   755  C C   . GLU A 1 98  ? -37.26425 55.70192 -3.76275  1.000 27.66646  ? 98  GLU A C   1 
ATOM   756  O O   . GLU A 1 98  ? -36.90307 55.74324 -4.94140  1.000 29.85646  ? 98  GLU A O   1 
ATOM   757  C CB  . GLU A 1 98  ? -36.42456 58.00286 -3.19601  1.000 40.24646  ? 98  GLU A CB  1 
ATOM   758  C CG  . GLU A 1 98  ? -35.10957 57.61087 -2.56162  1.000 50.03646  ? 98  GLU A CG  1 
ATOM   759  C CD  . GLU A 1 98  ? -34.09596 58.74330 -2.60779  1.000 56.52646  ? 98  GLU A CD  1 
ATOM   760  O OE1 . GLU A 1 98  ? -34.50585 59.90768 -2.40446  1.000 61.88646  ? 98  GLU A OE1 1 
ATOM   761  O OE2 . GLU A 1 98  ? -32.89810 58.47333 -2.85522  1.000 49.11646  ? 98  GLU A OE2 1 
ATOM   762  N N   . PHE A 1 99  ? -37.42794 54.55424 -3.10668  1.000 32.71599  ? 99  PHE A N   1 
ATOM   763  C CA  . PHE A 1 99  ? -37.20211 53.24866 -3.72805  1.000 26.33599  ? 99  PHE A CA  1 
ATOM   764  C C   . PHE A 1 99  ? -38.23595 52.99819 -4.81392  1.000 28.41599  ? 99  PHE A C   1 
ATOM   765  O O   . PHE A 1 99  ? -39.42168 52.81585 -4.51511  1.000 29.93599  ? 99  PHE A O   1 
ATOM   766  C CB  . PHE A 1 99  ? -37.24998 52.17235 -2.64487  1.000 22.75599  ? 99  PHE A CB  1 
ATOM   767  C CG  . PHE A 1 99  ? -36.98735 50.76908 -3.13472  1.000 21.13599  ? 99  PHE A CG  1 
ATOM   768  C CD1 . PHE A 1 99  ? -35.88292 50.47939 -3.92989  1.000 19.43599  ? 99  PHE A CD1 1 
ATOM   769  C CD2 . PHE A 1 99  ? -37.82145 49.72354 -2.73729  1.000 18.99599  ? 99  PHE A CD2 1 
ATOM   770  C CE1 . PHE A 1 99  ? -35.63366 49.17405 -4.34121  1.000 19.27599  ? 99  PHE A CE1 1 
ATOM   771  C CE2 . PHE A 1 99  ? -37.58383 48.42108 -3.13710  1.000 19.14599  ? 99  PHE A CE2 1 
ATOM   772  C CZ  . PHE A 1 99  ? -36.48633 48.13760 -3.93919  1.000 20.33599  ? 99  PHE A CZ  1 
ATOM   773  N N   . ASN A 1 100 ? -37.78644 53.02081 -6.08568  1.000 24.72406  ? 100 ASN A N   1 
ATOM   774  C CA  . ASN A 1 100 ? -38.62188 52.62660 -7.21867  1.000 27.19406  ? 100 ASN A CA  1 
ATOM   775  C C   . ASN A 1 100 ? -37.94988 51.68044 -8.20366  1.000 29.95406  ? 100 ASN A C   1 
ATOM   776  O O   . ASN A 1 100 ? -38.66583 50.97340 -8.91961  1.000 35.93406  ? 100 ASN A O   1 
ATOM   777  C CB  . ASN A 1 100 ? -39.12064 53.84701 -8.01404  1.000 30.80406  ? 100 ASN A CB  1 
ATOM   778  C CG  . ASN A 1 100 ? -40.04889 54.72995 -7.22420  1.000 41.04406  ? 100 ASN A CG  1 
ATOM   779  O OD1 . ASN A 1 100 ? -41.17841 54.34207 -6.90901  1.000 49.60406  ? 100 ASN A OD1 1 
ATOM   780  N ND2 . ASN A 1 100 ? -39.59283 55.94422 -6.92460  1.000 47.68406  ? 100 ASN A ND2 1 
ATOM   781  N N   . ASP A 1 101 ? -36.62901 51.64991 -8.30770  1.000 28.82011  ? 101 ASP A N   1 
ATOM   782  C CA  . ASP A 1 101 ? -35.98289 50.81736 -9.30920  1.000 25.04011  ? 101 ASP A CA  1 
ATOM   783  C C   . ASP A 1 101 ? -35.13671 49.74389 -8.64532  1.000 20.48011  ? 101 ASP A C   1 
ATOM   784  O O   . ASP A 1 101 ? -34.50417 49.98798 -7.61723  1.000 20.65011  ? 101 ASP A O   1 
ATOM   785  C CB  . ASP A 1 101 ? -35.12631 51.65648 -10.24820 1.000 31.06011  ? 101 ASP A CB  1 
ATOM   786  C CG  . ASP A 1 101 ? -35.97018 52.46767 -11.22661 1.000 45.04011  ? 101 ASP A CG  1 
ATOM   787  O OD1 . ASP A 1 101 ? -37.11183 52.03332 -11.53167 1.000 53.12011  ? 101 ASP A OD1 1 
ATOM   788  O OD2 . ASP A 1 101 ? -35.49830 53.52476 -11.69689 1.000 61.87011  ? 101 ASP A OD2 1 
ATOM   789  N N   . VAL A 1 102 ? -35.13460 48.55616 -9.24170  1.000 16.99477  ? 102 VAL A N   1 
ATOM   790  C CA  . VAL A 1 102 ? -34.35526 47.41827 -8.77635  1.000 18.64477  ? 102 VAL A CA  1 
ATOM   791  C C   . VAL A 1 102 ? -33.52412 46.91411 -9.95291  1.000 15.07477  ? 102 VAL A C   1 
ATOM   792  O O   . VAL A 1 102 ? -34.05131 46.72701 -11.05999 1.000 17.26477  ? 102 VAL A O   1 
ATOM   793  C CB  . VAL A 1 102 ? -35.24767 46.27357 -8.24610  1.000 21.28477  ? 102 VAL A CB  1 
ATOM   794  C CG1 . VAL A 1 102 ? -34.39203 45.08267 -7.80848  1.000 25.83477  ? 102 VAL A CG1 1 
ATOM   795  C CG2 . VAL A 1 102 ? -36.10341 46.73276 -7.11366  1.000 25.33477  ? 102 VAL A CG2 1 
ATOM   796  N N   . TYR A 1 103 ? -32.24879 46.65851 -9.70471  1.000 15.19575  ? 103 TYR A N   1 
ATOM   797  C CA  . TYR A 1 103 ? -31.33777 46.14804 -10.71511 1.000 15.33575  ? 103 TYR A CA  1 
ATOM   798  C C   . TYR A 1 103 ? -30.69258 44.86414 -10.20992 1.000 16.30575  ? 103 TYR A C   1 
ATOM   799  O O   . TYR A 1 103 ? -30.27975 44.78744 -9.05152  1.000 16.44575  ? 103 TYR A O   1 
ATOM   800  C CB  . TYR A 1 103 ? -30.24567 47.16452 -11.03940 1.000 15.77575  ? 103 TYR A CB  1 
ATOM   801  C CG  . TYR A 1 103 ? -30.65710 48.51078 -11.63340 1.000 14.44575  ? 103 TYR A CG  1 
ATOM   802  C CD1 . TYR A 1 103 ? -31.20970 49.51944 -10.84344 1.000 16.92575  ? 103 TYR A CD1 1 
ATOM   803  C CD2 . TYR A 1 103 ? -30.39937 48.80145 -12.97193 1.000 16.67575  ? 103 TYR A CD2 1 
ATOM   804  C CE1 . TYR A 1 103 ? -31.54410 50.77596 -11.39494 1.000 15.77575  ? 103 TYR A CE1 1 
ATOM   805  C CE2 . TYR A 1 103 ? -30.71813 50.02753 -13.52103 1.000 15.85575  ? 103 TYR A CE2 1 
ATOM   806  C CZ  . TYR A 1 103 ? -31.29035 51.01198 -12.73847 1.000 17.26575  ? 103 TYR A CZ  1 
ATOM   807  O OH  . TYR A 1 103 ? -31.59117 52.23535 -13.30374 1.000 17.39575  ? 103 TYR A OH  1 
ATOM   808  N N   . LEU A 1 104 ? -30.60284 43.86185 -11.07692 1.000 16.55714  ? 104 LEU A N   1 
ATOM   809  C CA  . LEU A 1 104 ? -30.03189 42.55877 -10.74310 1.000 14.51714  ? 104 LEU A CA  1 
ATOM   810  C C   . LEU A 1 104 ? -28.82719 42.29928 -11.63302 1.000 15.39714  ? 104 LEU A C   1 
ATOM   811  O O   . LEU A 1 104 ? -28.88310 42.53997 -12.84060 1.000 17.34714  ? 104 LEU A O   1 
ATOM   812  C CB  . LEU A 1 104 ? -31.04925 41.42672 -10.94876 1.000 17.20714  ? 104 LEU A CB  1 
ATOM   813  C CG  . LEU A 1 104 ? -32.40939 41.53063 -10.25459 1.000 20.43714  ? 104 LEU A CG  1 
ATOM   814  C CD1 . LEU A 1 104 ? -33.35976 40.47142 -10.82488 1.000 26.27714  ? 104 LEU A CD1 1 
ATOM   815  C CD2 . LEU A 1 104 ? -32.26851 41.36147 -8.73773  1.000 18.30714  ? 104 LEU A CD2 1 
ATOM   816  N N   . VAL A 1 105 ? -27.73821 41.80487 -11.04761 1.000 16.21205  ? 105 VAL A N   1 
ATOM   817  C CA  . VAL A 1 105 ? -26.50405 41.55739 -11.78860 1.000 16.94205  ? 105 VAL A CA  1 
ATOM   818  C C   . VAL A 1 105 ? -26.19297 40.06999 -11.70234 1.000 16.71205  ? 105 VAL A C   1 
ATOM   819  O O   . VAL A 1 105 ? -26.18135 39.49911 -10.60550 1.000 15.07205  ? 105 VAL A O   1 
ATOM   820  C CB  . VAL A 1 105 ? -25.32101 42.38898 -11.25129 1.000 18.23205  ? 105 VAL A CB  1 
ATOM   821  C CG1 . VAL A 1 105 ? -24.10203 42.20847 -12.14126 1.000 18.99205  ? 105 VAL A CG1 1 
ATOM   822  C CG2 . VAL A 1 105 ? -25.67953 43.85272 -11.15647 1.000 18.34205  ? 105 VAL A CG2 1 
ATOM   823  N N   . THR A 1 106 ? -25.96465 39.44341 -12.86151 1.000 18.67111  ? 106 THR A N   1 
ATOM   824  C CA  . THR A 1 106 ? -25.57059 38.04290 -12.94320 1.000 24.22111  ? 106 THR A CA  1 
ATOM   825  C C   . THR A 1 106 ? -24.42828 37.91470 -13.94446 1.000 27.43111  ? 106 THR A C   1 
ATOM   826  O O   . THR A 1 106 ? -24.11653 38.85097 -14.68568 1.000 25.23111  ? 106 THR A O   1 
ATOM   827  C CB  . THR A 1 106 ? -26.74447 37.14530 -13.36400 1.000 26.91111  ? 106 THR A CB  1 
ATOM   828  O OG1 . THR A 1 106 ? -27.33623 37.66854 -14.55944 1.000 29.98111  ? 106 THR A OG1 1 
ATOM   829  C CG2 . THR A 1 106 ? -27.81373 37.09873 -12.28071 1.000 25.84111  ? 106 THR A CG2 1 
ATOM   830  N N   . HIS A 1 107 ? -23.78544 36.74789 -13.94378 1.000 36.82156  ? 107 HIS A N   1 
ATOM   831  C CA  . HIS A 1 107 ? -22.75213 36.45742 -14.93496 1.000 42.29156  ? 107 HIS A CA  1 
ATOM   832  C C   . HIS A 1 107 ? -23.32741 36.56933 -16.33801 1.000 41.87156  ? 107 HIS A C   1 
ATOM   833  O O   . HIS A 1 107 ? -24.42884 36.07612 -16.60602 1.000 27.21156  ? 107 HIS A O   1 
ATOM   834  C CB  . HIS A 1 107 ? -22.18809 35.05236 -14.72625 1.000 51.29156  ? 107 HIS A CB  1 
ATOM   835  C CG  . HIS A 1 107 ? -21.18837 34.95155 -13.61820 1.000 62.17156  ? 107 HIS A CG  1 
ATOM   836  N ND1 . HIS A 1 107 ? -20.03950 35.71357 -13.58000 1.000 69.76156  ? 107 HIS A ND1 1 
ATOM   837  C CD2 . HIS A 1 107 ? -21.15363 34.15982 -12.51872 1.000 69.90156  ? 107 HIS A CD2 1 
ATOM   838  C CE1 . HIS A 1 107 ? -19.34628 35.40416 -12.49761 1.000 76.19156  ? 107 HIS A CE1 1 
ATOM   839  N NE2 . HIS A 1 107 ? -19.99963 34.46361 -11.83695 1.000 76.14156  ? 107 HIS A NE2 1 
ATOM   840  N N   . LEU A 1 108 ? -22.59904 37.26235 -17.21373 1.000 40.18093  ? 108 LEU A N   1 
ATOM   841  C CA  . LEU A 1 108 ? -22.98122 37.32457 -18.61621 1.000 41.68093  ? 108 LEU A CA  1 
ATOM   842  C C   . LEU A 1 108 ? -22.62883 36.01655 -19.29309 1.000 46.92093  ? 108 LEU A C   1 
ATOM   843  O O   . LEU A 1 108 ? -21.48210 35.54845 -19.23870 1.000 40.51093  ? 108 LEU A O   1 
ATOM   844  C CB  . LEU A 1 108 ? -22.29229 38.47494 -19.34110 1.000 43.35093  ? 108 LEU A CB  1 
ATOM   845  C CG  . LEU A 1 108 ? -22.78118 38.65451 -20.77996 1.000 42.76093  ? 108 LEU A CG  1 
ATOM   846  C CD1 . LEU A 1 108 ? -24.24763 39.06416 -20.78905 1.000 37.20093  ? 108 LEU A CD1 1 
ATOM   847  C CD2 . LEU A 1 108 ? -21.91908 39.66131 -21.54336 1.000 44.94093  ? 108 LEU A CD2 1 
ATOM   848  N N   . MET A 1 109 ? -23.61956 35.43278 -19.93768 1.000 41.98517  ? 109 MET A N   1 
ATOM   849  C CA  . MET A 1 109 ? -23.49904 34.09479 -20.47593 1.000 54.11517  ? 109 MET A CA  1 
ATOM   850  C C   . MET A 1 109 ? -23.39941 34.18539 -21.98963 1.000 42.22517  ? 109 MET A C   1 
ATOM   851  O O   . MET A 1 109 ? -24.28933 34.74300 -22.65026 1.000 42.27517  ? 109 MET A O   1 
ATOM   852  C CB  . MET A 1 109 ? -24.67346 33.25734 -19.98460 1.000 60.70517  ? 109 MET A CB  1 
ATOM   853  C CG  . MET A 1 109 ? -24.71304 33.19679 -18.42876 1.000 59.38517  ? 109 MET A CG  1 
ATOM   854  S SD  . MET A 1 109 ? -23.62239 31.98023 -17.61872 1.000 54.87517  ? 109 MET A SD  1 
ATOM   855  C CE  . MET A 1 109 ? -21.98818 32.72170 -17.56456 1.000 59.14517  ? 109 MET A CE  1 
ATOM   856  N N   . GLY A 1 110 ? -22.28898 33.66625 -22.51607 1.000 46.87955  ? 110 GLY A N   1 
ATOM   857  C CA  . GLY A 1 110 ? -21.95144 33.89999 -23.90649 1.000 48.61955  ? 110 GLY A CA  1 
ATOM   858  C C   . GLY A 1 110 ? -22.79846 33.08701 -24.87351 1.000 42.95955  ? 110 GLY A C   1 
ATOM   859  O O   . GLY A 1 110 ? -23.18699 33.58321 -25.93528 1.000 61.67955  ? 110 GLY A O   1 
ATOM   860  N N   . ALA A 1 111 ? -23.10801 31.83460 -24.52940 1.000 38.84697  ? 111 ALA A N   1 
ATOM   861  C CA  . ALA A 1 111 ? -23.81071 30.95548 -25.45749 1.000 30.73697  ? 111 ALA A CA  1 
ATOM   862  C C   . ALA A 1 111 ? -24.79283 30.08929 -24.69714 1.000 22.56697  ? 111 ALA A C   1 
ATOM   863  O O   . ALA A 1 111 ? -24.50338 29.64960 -23.58208 1.000 25.73697  ? 111 ALA A O   1 
ATOM   864  C CB  . ALA A 1 111 ? -22.84500 30.05386 -26.22642 1.000 26.33697  ? 111 ALA A CB  1 
ATOM   865  N N   . ASP A 1 112 ? -25.93719 29.82670 -25.31936 1.000 21.97129  ? 112 ASP A N   1 
ATOM   866  C CA  . ASP A 1 112 ? -26.87106 28.85128 -24.79071 1.000 18.95129  ? 112 ASP A CA  1 
ATOM   867  C C   . ASP A 1 112 ? -26.69414 27.51924 -25.52665 1.000 18.72129  ? 112 ASP A C   1 
ATOM   868  O O   . ASP A 1 112 ? -25.85728 27.37680 -26.42485 1.000 17.31129  ? 112 ASP A O   1 
ATOM   869  C CB  . ASP A 1 112 ? -28.32716 29.36350 -24.82303 1.000 18.44129  ? 112 ASP A CB  1 
ATOM   870  C CG  . ASP A 1 112 ? -28.88725 29.63356 -26.23324 1.000 27.99129  ? 112 ASP A CG  1 
ATOM   871  O OD1 . ASP A 1 112 ? -28.69794 28.84350 -27.18748 1.000 28.80129  ? 112 ASP A OD1 1 
ATOM   872  O OD2 . ASP A 1 112 ? -29.62218 30.63434 -26.36729 1.000 43.95129  ? 112 ASP A OD2 1 
ATOM   873  N N   . LEU A 1 113 ? -27.50558 26.53416 -25.13858 1.000 17.43507  ? 113 LEU A N   1 
ATOM   874  C CA  . LEU A 1 113 ? -27.36770 25.19511 -25.70524 1.000 20.43507  ? 113 LEU A CA  1 
ATOM   875  C C   . LEU A 1 113 ? -27.74450 25.14939 -27.18582 1.000 19.92507  ? 113 LEU A C   1 
ATOM   876  O O   . LEU A 1 113 ? -27.13910 24.37536 -27.94374 1.000 21.97507  ? 113 LEU A O   1 
ATOM   877  C CB  . LEU A 1 113 ? -28.20529 24.21648 -24.89846 1.000 23.08507  ? 113 LEU A CB  1 
ATOM   878  C CG  . LEU A 1 113 ? -27.93087 22.72964 -25.11038 1.000 27.09507  ? 113 LEU A CG  1 
ATOM   879  C CD1 . LEU A 1 113 ? -26.46560 22.39702 -24.94395 1.000 29.45507  ? 113 LEU A CD1 1 
ATOM   880  C CD2 . LEU A 1 113 ? -28.73692 21.96879 -24.10522 1.000 31.43507  ? 113 LEU A CD2 1 
ATOM   881  N N   . ASN A 1 114 ? -28.71880 25.95992 -27.62174 1.000 17.42179  ? 114 ASN A N   1 
ATOM   882  C CA  . ASN A 1 114 ? -29.01368 26.06016 -29.05817 1.000 20.10179  ? 114 ASN A CA  1 
ATOM   883  C C   . ASN A 1 114 ? -27.82670 26.61231 -29.83561 1.000 22.86179  ? 114 ASN A C   1 
ATOM   884  O O   . ASN A 1 114 ? -27.54079 26.16045 -30.95046 1.000 23.87179  ? 114 ASN A O   1 
ATOM   885  C CB  . ASN A 1 114 ? -30.23169 26.94409 -29.30924 1.000 24.89179  ? 114 ASN A CB  1 
ATOM   886  C CG  . ASN A 1 114 ? -31.51386 26.30297 -28.86608 1.000 28.94179  ? 114 ASN A CG  1 
ATOM   887  O OD1 . ASN A 1 114 ? -31.72778 25.09816 -29.06044 1.000 31.95179  ? 114 ASN A OD1 1 
ATOM   888  N ND2 . ASN A 1 114 ? -32.38341 27.09865 -28.25829 1.000 32.34179  ? 114 ASN A ND2 1 
ATOM   889  N N   . ASN A 1 115 ? -27.10814 27.57278 -29.25437 1.000 19.43318  ? 115 ASN A N   1 
ATOM   890  C CA  . ASN A 1 115 ? -25.97905 28.17910 -29.94929 1.000 21.33318  ? 115 ASN A CA  1 
ATOM   891  C C   . ASN A 1 115 ? -24.82675 27.20503 -30.10835 1.000 20.18318  ? 115 ASN A C   1 
ATOM   892  O O   . ASN A 1 115 ? -24.17020 27.19859 -31.15432 1.000 20.32318  ? 115 ASN A O   1 
ATOM   893  C CB  . ASN A 1 115 ? -25.49076 29.42844 -29.20933 1.000 28.64318  ? 115 ASN A CB  1 
ATOM   894  C CG  . ASN A 1 115 ? -26.48927 30.55893 -29.24959 1.000 38.58318  ? 115 ASN A CG  1 
ATOM   895  O OD1 . ASN A 1 115 ? -27.18054 30.75882 -30.25101 1.000 49.78318  ? 115 ASN A OD1 1 
ATOM   896  N ND2 . ASN A 1 115 ? -26.57862 31.31064 -28.14993 1.000 46.53318  ? 115 ASN A ND2 1 
ATOM   897  N N   . ILE A 1 116 ? -24.55147 26.37180 -29.09295 1.000 17.71359  ? 116 ILE A N   1 
ATOM   898  C CA  . ILE A 1 116 ? -23.34654 25.55757 -29.20144 1.000 19.28359  ? 116 ILE A CA  1 
ATOM   899  C C   . ILE A 1 116 ? -23.51533 24.45829 -30.25695 1.000 19.08359  ? 116 ILE A C   1 
ATOM   900  O O   . ILE A 1 116 ? -22.53342 24.06280 -30.89841 1.000 16.23359  ? 116 ILE A O   1 
ATOM   901  C CB  . ILE A 1 116 ? -22.90016 24.96397 -27.84948 1.000 22.88359  ? 116 ILE A CB  1 
ATOM   902  C CG1 . ILE A 1 116 ? -23.83372 23.87755 -27.35966 1.000 33.77359  ? 116 ILE A CG1 1 
ATOM   903  C CG2 . ILE A 1 116 ? -22.71366 26.05175 -26.78567 1.000 27.43359  ? 116 ILE A CG2 1 
ATOM   904  C CD1 . ILE A 1 116 ? -23.17066 23.01881 -26.31646 1.000 43.34359  ? 116 ILE A CD1 1 
ATOM   905  N N   . VAL A 1 117 ? -24.74063 23.97526 -30.48744 1.000 17.69594  ? 117 VAL A N   1 
ATOM   906  C CA  . VAL A 1 117 ? -24.91318 22.95559 -31.51918 1.000 19.87594  ? 117 VAL A CA  1 
ATOM   907  C C   . VAL A 1 117 ? -24.87802 23.55660 -32.91630 1.000 20.88594  ? 117 VAL A C   1 
ATOM   908  O O   . VAL A 1 117 ? -24.68530 22.81984 -33.89356 1.000 17.66594  ? 117 VAL A O   1 
ATOM   909  C CB  . VAL A 1 117 ? -26.20744 22.15464 -31.30404 1.000 24.68594  ? 117 VAL A CB  1 
ATOM   910  C CG1 . VAL A 1 117 ? -26.29041 21.64990 -29.85309 1.000 25.87594  ? 117 VAL A CG1 1 
ATOM   911  C CG2 . VAL A 1 117 ? -27.40171 22.98505 -31.63307 1.000 28.10594  ? 117 VAL A CG2 1 
ATOM   912  N N   . LYS A 1 118 ? -25.02002 24.87874 -33.04378 1.000 19.00117  ? 118 LYS A N   1 
ATOM   913  C CA  . LYS A 1 118 ? -24.99798 25.50573 -34.36249 1.000 20.80117  ? 118 LYS A CA  1 
ATOM   914  C C   . LYS A 1 118 ? -23.61442 25.46264 -34.99716 1.000 22.25117  ? 118 LYS A C   1 
ATOM   915  O O   . LYS A 1 118 ? -23.50114 25.52811 -36.22682 1.000 24.75117  ? 118 LYS A O   1 
ATOM   916  C CB  . LYS A 1 118 ? -25.47162 26.96146 -34.28803 1.000 21.67117  ? 118 LYS A CB  1 
ATOM   917  C CG  . LYS A 1 118 ? -26.93987 27.17210 -33.93043 1.000 28.56117  ? 118 LYS A CG  1 
ATOM   918  C CD  . LYS A 1 118 ? -27.84477 26.39420 -34.85114 1.000 35.44117  ? 118 LYS A CD  1 
ATOM   919  C CE  . LYS A 1 118 ? -29.33247 26.65975 -34.60775 1.000 41.06117  ? 118 LYS A CE  1 
ATOM   920  N NZ  . LYS A 1 118 ? -30.15330 25.74722 -35.49138 1.000 37.03117  ? 118 LYS A NZ  1 
ATOM   921  N N   . CYS A 1 119 ? -22.54782 25.37743 -34.20282 1.000 22.21770  ? 119 CYS A N   1 
ATOM   922  C CA  . CYS A 1 119 ? -21.21040 25.42589 -34.78454 1.000 24.85770  ? 119 CYS A CA  1 
ATOM   923  C C   . CYS A 1 119 ? -20.36449 24.18720 -34.50244 1.000 21.50770  ? 119 CYS A C   1 
ATOM   924  O O   . CYS A 1 119 ? -19.16833 24.21003 -34.81027 1.000 22.33770  ? 119 CYS A O   1 
ATOM   925  C CB  . CYS A 1 119 ? -20.45982 26.68512 -34.30932 1.000 37.01770  ? 119 CYS A CB  1 
ATOM   926  S SG  . CYS A 1 119 ? -20.90693 27.27327 -32.66464 1.000 48.78770  ? 119 CYS A SG  1 
ATOM   927  N N   . GLN A 1 120 ? -20.92704 23.12022 -33.92594 1.000 19.57461  ? 120 GLN A N   1 
ATOM   928  C CA  . GLN A 1 120 ? -20.16717 21.88277 -33.74195 1.000 19.78461  ? 120 GLN A CA  1 
ATOM   929  C C   . GLN A 1 120 ? -21.11233 20.72361 -33.48635 1.000 17.98461  ? 120 GLN A C   1 
ATOM   930  O O   . GLN A 1 120 ? -22.25868 20.90432 -33.08232 1.000 22.11461  ? 120 GLN A O   1 
ATOM   931  C CB  . GLN A 1 120 ? -19.15238 21.97117 -32.59444 1.000 20.70461  ? 120 GLN A CB  1 
ATOM   932  C CG  . GLN A 1 120 ? -19.78120 22.27131 -31.24842 1.000 22.06461  ? 120 GLN A CG  1 
ATOM   933  C CD  . GLN A 1 120 ? -19.05534 23.40952 -30.56401 1.000 26.70461  ? 120 GLN A CD  1 
ATOM   934  O OE1 . GLN A 1 120 ? -17.84993 23.32570 -30.32253 1.000 25.72461  ? 120 GLN A OE1 1 
ATOM   935  N NE2 . GLN A 1 120 ? -19.76801 24.49812 -30.29948 1.000 27.31461  ? 120 GLN A NE2 1 
ATOM   936  N N   . LYS A 1 121 ? -20.61121 19.52415 -33.74177 1.000 17.32012  ? 121 LYS A N   1 
ATOM   937  C CA  . LYS A 1 121 ? -21.31955 18.29732 -33.41219 1.000 20.20012  ? 121 LYS A CA  1 
ATOM   938  C C   . LYS A 1 121 ? -20.80899 17.83317 -32.05653 1.000 19.96012  ? 121 LYS A C   1 
ATOM   939  O O   . LYS A 1 121 ? -19.61355 17.56735 -31.90333 1.000 19.09012  ? 121 LYS A O   1 
ATOM   940  C CB  . LYS A 1 121 ? -21.09148 17.21605 -34.47111 1.000 19.76012  ? 121 LYS A CB  1 
ATOM   941  C CG  . LYS A 1 121 ? -21.90781 15.93861 -34.26128 1.000 21.23012  ? 121 LYS A CG  1 
ATOM   942  C CD  . LYS A 1 121 ? -21.47829 14.86404 -35.26851 1.000 24.60012  ? 121 LYS A CD  1 
ATOM   943  C CE  . LYS A 1 121 ? -22.28265 13.57536 -35.13951 1.000 26.77012  ? 121 LYS A CE  1 
ATOM   944  N NZ  . LYS A 1 121 ? -22.12326 12.94798 -33.81268 1.000 31.51012  ? 121 LYS A NZ  1 
ATOM   945  N N   . LEU A 1 122 ? -21.70724 17.74082 -31.08056 1.000 19.97383  ? 122 LEU A N   1 
ATOM   946  C CA  . LEU A 1 122 ? -21.30774 17.30187 -29.75020 1.000 21.55383  ? 122 LEU A CA  1 
ATOM   947  C C   . LEU A 1 122 ? -20.97002 15.81489 -29.76240 1.000 22.46383  ? 122 LEU A C   1 
ATOM   948  O O   . LEU A 1 122 ? -21.69486 15.00599 -30.34996 1.000 24.23383  ? 122 LEU A O   1 
ATOM   949  C CB  . LEU A 1 122 ? -22.42832 17.58655 -28.74671 1.000 20.68383  ? 122 LEU A CB  1 
ATOM   950  C CG  . LEU A 1 122 ? -22.77050 19.06833 -28.58219 1.000 26.10383  ? 122 LEU A CG  1 
ATOM   951  C CD1 . LEU A 1 122 ? -23.95637 19.26506 -27.62392 1.000 25.65383  ? 122 LEU A CD1 1 
ATOM   952  C CD2 . LEU A 1 122 ? -21.54042 19.84216 -28.09974 1.000 30.82383  ? 122 LEU A CD2 1 
ATOM   953  N N   . THR A 1 123 ? -19.85828 15.45623 -29.11937 1.000 21.68214  ? 123 THR A N   1 
ATOM   954  C CA  . THR A 1 123 ? -19.51374 14.05689 -28.91228 1.000 25.31214  ? 123 THR A CA  1 
ATOM   955  C C   . THR A 1 123 ? -20.36522 13.47754 -27.78583 1.000 25.36214  ? 123 THR A C   1 
ATOM   956  O O   . THR A 1 123 ? -21.03139 14.20665 -27.04692 1.000 18.19214  ? 123 THR A O   1 
ATOM   957  C CB  . THR A 1 123 ? -18.02659 13.90380 -28.58458 1.000 32.81214  ? 123 THR A CB  1 
ATOM   958  O OG1 . THR A 1 123 ? -17.74433 14.50780 -27.31340 1.000 31.35214  ? 123 THR A OG1 1 
ATOM   959  C CG2 . THR A 1 123 ? -17.17862 14.58563 -29.66009 1.000 33.74214  ? 123 THR A CG2 1 
ATOM   960  N N   . ASP A 1 124 ? -20.33847 12.14392 -27.65015 1.000 21.61631  ? 124 ASP A N   1 
ATOM   961  C CA  . ASP A 1 124 ? -21.06806 11.52825 -26.54682 1.000 24.73631  ? 124 ASP A CA  1 
ATOM   962  C C   . ASP A 1 124 ? -20.46842 11.93297 -25.20103 1.000 22.50631  ? 124 ASP A C   1 
ATOM   963  O O   . ASP A 1 124 ? -21.20205 12.02867 -24.21441 1.000 18.41631  ? 124 ASP A O   1 
ATOM   964  C CB  . ASP A 1 124 ? -21.11487 10.00335 -26.69964 1.000 25.72631  ? 124 ASP A CB  1 
ATOM   965  C CG  . ASP A 1 124 ? -22.00957 9.32574  -25.64655 1.000 28.64631  ? 124 ASP A CG  1 
ATOM   966  O OD1 . ASP A 1 124 ? -23.22801 9.62352  -25.56456 1.000 29.94631  ? 124 ASP A OD1 1 
ATOM   967  O OD2 . ASP A 1 124 ? -21.50112 8.46807  -24.89439 1.000 27.93631  ? 124 ASP A OD2 1 
ATOM   968  N N   . ASP A 1 125 ? -19.15879 12.22955 -25.15744 1.000 22.32783  ? 125 ASP A N   1 
ATOM   969  C CA  . ASP A 1 125 ? -18.55022 12.79033 -23.94869 1.000 24.17783  ? 125 ASP A CA  1 
ATOM   970  C C   . ASP A 1 125 ? -19.13780 14.15781 -23.61393 1.000 21.88783  ? 125 ASP A C   1 
ATOM   971  O O   . ASP A 1 125 ? -19.38696 14.46224 -22.44089 1.000 17.16783  ? 125 ASP A O   1 
ATOM   972  C CB  . ASP A 1 125 ? -17.03259 12.92477 -24.11087 1.000 31.00783  ? 125 ASP A CB  1 
ATOM   973  C CG  . ASP A 1 125 ? -16.32205 11.58686 -24.17852 1.000 44.47783  ? 125 ASP A CG  1 
ATOM   974  O OD1 . ASP A 1 125 ? -16.82907 10.59191 -23.60410 1.000 48.78783  ? 125 ASP A OD1 1 
ATOM   975  O OD2 . ASP A 1 125 ? -15.24017 11.53817 -24.80415 1.000 61.02783  ? 125 ASP A OD2 1 
ATOM   976  N N   . HIS A 1 126 ? -19.32360 15.00769 -24.63220 1.000 20.30589  ? 126 HIS A N   1 
ATOM   977  C CA  . HIS A 1 126 ? -19.92463 16.32380 -24.42185 1.000 19.92589  ? 126 HIS A CA  1 
ATOM   978  C C   . HIS A 1 126 ? -21.32723 16.20497 -23.84264 1.000 16.52589  ? 126 HIS A C   1 
ATOM   979  O O   . HIS A 1 126 ? -21.70108 16.97182 -22.94349 1.000 15.09589  ? 126 HIS A O   1 
ATOM   980  C CB  . HIS A 1 126 ? -19.98118 17.10143 -25.73646 1.000 24.44589  ? 126 HIS A CB  1 
ATOM   981  C CG  . HIS A 1 126 ? -18.65027 17.59515 -26.21328 1.000 30.76589  ? 126 HIS A CG  1 
ATOM   982  N ND1 . HIS A 1 126 ? -18.22577 17.44455 -27.51755 1.000 36.57589  ? 126 HIS A ND1 1 
ATOM   983  C CD2 . HIS A 1 126 ? -17.66166 18.25832 -25.57186 1.000 36.89589  ? 126 HIS A CD2 1 
ATOM   984  C CE1 . HIS A 1 126 ? -17.02614 17.97820 -27.65290 1.000 30.60589  ? 126 HIS A CE1 1 
ATOM   985  N NE2 . HIS A 1 126 ? -16.66347 18.48500 -26.48868 1.000 33.65589  ? 126 HIS A NE2 1 
ATOM   986  N N   . VAL A 1 127 ? -22.11958 15.25346 -24.35362 1.000 17.04197  ? 127 VAL A N   1 
ATOM   987  C CA  . VAL A 1 127 ? -23.50025 15.10675 -23.90238 1.000 16.47197  ? 127 VAL A CA  1 
ATOM   988  C C   . VAL A 1 127 ? -23.54071 14.57819 -22.47056 1.000 15.45197  ? 127 VAL A C   1 
ATOM   989  O O   . VAL A 1 127 ? -24.33952 15.04921 -21.64756 1.000 13.74197  ? 127 VAL A O   1 
ATOM   990  C CB  . VAL A 1 127 ? -24.28663 14.21194 -24.88222 1.000 15.82197  ? 127 VAL A CB  1 
ATOM   991  C CG1 . VAL A 1 127 ? -25.75440 14.02506 -24.42665 1.000 16.05197  ? 127 VAL A CG1 1 
ATOM   992  C CG2 . VAL A 1 127 ? -24.24455 14.79711 -26.28864 1.000 17.77197  ? 127 VAL A CG2 1 
ATOM   993  N N   . GLN A 1 128 ? -22.68290 13.60008 -22.14525 1.000 13.77114  ? 128 GLN A N   1 
ATOM   994  C CA  . GLN A 1 128 ? -22.57343 13.12773 -20.75629 1.000 16.75114  ? 128 GLN A CA  1 
ATOM   995  C C   . GLN A 1 128 ? -22.29718 14.28295 -19.79843 1.000 14.27114  ? 128 GLN A C   1 
ATOM   996  O O   . GLN A 1 128 ? -22.98782 14.43540 -18.79151 1.000 12.55114  ? 128 GLN A O   1 
ATOM   997  C CB  . GLN A 1 128 ? -21.45517 12.08769 -20.59788 1.000 16.93114  ? 128 GLN A CB  1 
ATOM   998  C CG  . GLN A 1 128 ? -21.69274 10.75471 -21.25050 1.000 19.99114  ? 128 GLN A CG  1 
ATOM   999  C CD  . GLN A 1 128 ? -20.43784 9.88756  -21.28483 1.000 24.83114  ? 128 GLN A CD  1 
ATOM   1000 O OE1 . GLN A 1 128 ? -19.55637 9.99612  -20.42123 1.000 25.19114  ? 128 GLN A OE1 1 
ATOM   1001 N NE2 . GLN A 1 128 ? -20.34602 9.03530  -22.30152 1.000 28.24114  ? 128 GLN A NE2 1 
ATOM   1002 N N   . PHE A 1 129 ? -21.32550 15.13488 -20.13518 1.000 14.70077  ? 129 PHE A N   1 
ATOM   1003 C CA  . PHE A 1 129 ? -20.93430 16.22226 -19.23831 1.000 14.81077  ? 129 PHE A CA  1 
ATOM   1004 C C   . PHE A 1 129 ? -22.03264 17.27309 -19.11791 1.000 14.94077  ? 129 PHE A C   1 
ATOM   1005 O O   . PHE A 1 129 ? -22.33266 17.73896 -18.00826 1.000 14.13077  ? 129 PHE A O   1 
ATOM   1006 C CB  . PHE A 1 129 ? -19.63300 16.86100 -19.72781 1.000 16.96077  ? 129 PHE A CB  1 
ATOM   1007 C CG  . PHE A 1 129 ? -19.03563 17.86160 -18.76432 1.000 16.60077  ? 129 PHE A CG  1 
ATOM   1008 C CD1 . PHE A 1 129 ? -18.99581 17.59532 -17.39598 1.000 21.07077  ? 129 PHE A CD1 1 
ATOM   1009 C CD2 . PHE A 1 129 ? -18.49727 19.05043 -19.22693 1.000 18.73077  ? 129 PHE A CD2 1 
ATOM   1010 C CE1 . PHE A 1 129 ? -18.43765 18.51513 -16.49731 1.000 20.46077  ? 129 PHE A CE1 1 
ATOM   1011 C CE2 . PHE A 1 129 ? -17.92720 19.97645 -18.33271 1.000 21.00077  ? 129 PHE A CE2 1 
ATOM   1012 C CZ  . PHE A 1 129 ? -17.90219 19.70450 -16.97053 1.000 21.41077  ? 129 PHE A CZ  1 
ATOM   1013 N N   . LEU A 1 130 ? -22.64456 17.65649 -20.24395 1.000 10.99730  ? 130 LEU A N   1 
ATOM   1014 C CA  . LEU A 1 130 ? -23.70849 18.65303 -20.20807 1.000 12.64730  ? 130 LEU A CA  1 
ATOM   1015 C C   . LEU A 1 130 ? -24.90195 18.16224 -19.40259 1.000 11.53730  ? 130 LEU A C   1 
ATOM   1016 O O   . LEU A 1 130 ? -25.40522 18.88174 -18.53528 1.000 10.08730  ? 130 LEU A O   1 
ATOM   1017 C CB  . LEU A 1 130 ? -24.13848 19.02391 -21.62713 1.000 13.50730  ? 130 LEU A CB  1 
ATOM   1018 C CG  . LEU A 1 130 ? -23.08892 19.82109 -22.40873 1.000 15.45730  ? 130 LEU A CG  1 
ATOM   1019 C CD1 . LEU A 1 130 ? -23.41832 19.83687 -23.90785 1.000 16.94730  ? 130 LEU A CD1 1 
ATOM   1020 C CD2 . LEU A 1 130 ? -23.00810 21.22617 -21.86209 1.000 17.00730  ? 130 LEU A CD2 1 
ATOM   1021 N N   . ILE A 1 131 ? -25.36778 16.93838 -19.66889 1.000 8.20793   ? 131 ILE A N   1 
ATOM   1022 C CA  . ILE A 1 131 ? -26.54568 16.45254 -18.95700 1.000 9.75793   ? 131 ILE A CA  1 
ATOM   1023 C C   . ILE A 1 131 ? -26.22139 16.25477 -17.47545 1.000 9.54793   ? 131 ILE A C   1 
ATOM   1024 O O   . ILE A 1 131 ? -27.05486 16.54259 -16.60724 1.000 9.29793   ? 131 ILE A O   1 
ATOM   1025 C CB  . ILE A 1 131 ? -27.08585 15.15808 -19.59539 1.000 9.00793   ? 131 ILE A CB  1 
ATOM   1026 C CG1 . ILE A 1 131 ? -27.49038 15.37757 -21.06923 1.000 11.20793  ? 131 ILE A CG1 1 
ATOM   1027 C CG2 . ILE A 1 131 ? -28.30630 14.66393 -18.83136 1.000 10.27793  ? 131 ILE A CG2 1 
ATOM   1028 C CD1 . ILE A 1 131 ? -28.56459 16.46598 -21.28739 1.000 12.20793  ? 131 ILE A CD1 1 
ATOM   1029 N N   . TYR A 1 132 ? -25.00876 15.76957 -17.17326 1.000 8.87065   ? 132 TYR A N   1 
ATOM   1030 C CA  . TYR A 1 132 ? -24.57825 15.59370 -15.78097 1.000 11.53065  ? 132 TYR A CA  1 
ATOM   1031 C C   . TYR A 1 132 ? -24.68522 16.90319 -15.00774 1.000 10.11065  ? 132 TYR A C   1 
ATOM   1032 O O   . TYR A 1 132 ? -25.22526 16.94435 -13.89503 1.000 8.49065   ? 132 TYR A O   1 
ATOM   1033 C CB  . TYR A 1 132 ? -23.13781 15.07573 -15.71479 1.000 11.85065  ? 132 TYR A CB  1 
ATOM   1034 C CG  . TYR A 1 132 ? -22.60692 15.03276 -14.28874 1.000 12.18065  ? 132 TYR A CG  1 
ATOM   1035 C CD1 . TYR A 1 132 ? -23.04098 14.05211 -13.40452 1.000 14.79065  ? 132 TYR A CD1 1 
ATOM   1036 C CD2 . TYR A 1 132 ? -21.71018 16.00178 -13.81737 1.000 14.83065  ? 132 TYR A CD2 1 
ATOM   1037 C CE1 . TYR A 1 132 ? -22.58866 14.02510 -12.08103 1.000 15.96065  ? 132 TYR A CE1 1 
ATOM   1038 C CE2 . TYR A 1 132 ? -21.24121 15.97519 -12.49027 1.000 16.24065  ? 132 TYR A CE2 1 
ATOM   1039 C CZ  . TYR A 1 132 ? -21.69258 14.99119 -11.63494 1.000 17.07065  ? 132 TYR A CZ  1 
ATOM   1040 O OH  . TYR A 1 132 ? -21.24984 14.94901 -10.32334 1.000 21.94065  ? 132 TYR A OH  1 
ATOM   1041 N N   . GLN A 1 133 ? -24.19981 17.98571 -15.60159 1.000 9.95194   ? 133 GLN A N   1 
ATOM   1042 C CA  . GLN A 1 133 ? -24.25472 19.28876 -14.94062 1.000 11.85194  ? 133 GLN A CA  1 
ATOM   1043 C C   . GLN A 1 133 ? -25.68316 19.78150 -14.76879 1.000 10.80194  ? 133 GLN A C   1 
ATOM   1044 O O   . GLN A 1 133 ? -26.00665 20.40247 -13.74396 1.000 10.37194  ? 133 GLN A O   1 
ATOM   1045 C CB  . GLN A 1 133 ? -23.45021 20.30176 -15.72989 1.000 11.87194  ? 133 GLN A CB  1 
ATOM   1046 C CG  . GLN A 1 133 ? -21.98906 20.04761 -15.69896 1.000 12.93194  ? 133 GLN A CG  1 
ATOM   1047 C CD  . GLN A 1 133 ? -21.27953 21.03931 -16.56252 1.000 13.63194  ? 133 GLN A CD  1 
ATOM   1048 O OE1 . GLN A 1 133 ? -20.87929 22.09457 -16.09088 1.000 16.12194  ? 133 GLN A OE1 1 
ATOM   1049 N NE2 . GLN A 1 133 ? -21.14297 20.72435 -17.85544 1.000 14.09194  ? 133 GLN A NE2 1 
ATOM   1050 N N   . ILE A 1 134 ? -26.54668 19.53917 -15.75978 1.000 10.39471  ? 134 ILE A N   1 
ATOM   1051 C CA  . ILE A 1 134 ? -27.95226 19.89976 -15.59866 1.000 9.49471   ? 134 ILE A CA  1 
ATOM   1052 C C   . ILE A 1 134 ? -28.55096 19.17324 -14.40606 1.000 8.86471   ? 134 ILE A C   1 
ATOM   1053 O O   . ILE A 1 134 ? -29.19276 19.78552 -13.54876 1.000 8.73471   ? 134 ILE A O   1 
ATOM   1054 C CB  . ILE A 1 134 ? -28.75544 19.60317 -16.87383 1.000 9.27471   ? 134 ILE A CB  1 
ATOM   1055 C CG1 . ILE A 1 134 ? -28.25599 20.44067 -18.04767 1.000 9.55471   ? 134 ILE A CG1 1 
ATOM   1056 C CG2 . ILE A 1 134 ? -30.23784 19.88229 -16.61299 1.000 10.34471  ? 134 ILE A CG2 1 
ATOM   1057 C CD1 . ILE A 1 134 ? -28.91197 20.06864 -19.37580 1.000 9.75471   ? 134 ILE A CD1 1 
ATOM   1058 N N   . LEU A 1 135 ? -28.32012 17.85825 -14.31547 1.000 8.43618   ? 135 LEU A N   1 
ATOM   1059 C CA  . LEU A 1 135 ? -28.88874 17.08837 -13.21581 1.000 9.41618   ? 135 LEU A CA  1 
ATOM   1060 C C   . LEU A 1 135 ? -28.26419 17.47148 -11.87972 1.000 10.42618  ? 135 LEU A C   1 
ATOM   1061 O O   . LEU A 1 135 ? -28.93164 17.40621 -10.83841 1.000 8.74618   ? 135 LEU A O   1 
ATOM   1062 C CB  . LEU A 1 135 ? -28.69995 15.59136 -13.46449 1.000 10.10618  ? 135 LEU A CB  1 
ATOM   1063 C CG  . LEU A 1 135 ? -29.42503 15.06489 -14.70192 1.000 10.77618  ? 135 LEU A CG  1 
ATOM   1064 C CD1 . LEU A 1 135 ? -28.86639 13.72817 -15.05638 1.000 12.11618  ? 135 LEU A CD1 1 
ATOM   1065 C CD2 . LEU A 1 135 ? -30.92041 14.97174 -14.42072 1.000 10.81618  ? 135 LEU A CD2 1 
ATOM   1066 N N   . ARG A 1 136 ? -26.99422 17.85645 -11.89546 1.000 9.47869   ? 136 ARG A N   1 
ATOM   1067 C CA  . ARG A 1 136 ? -26.35057 18.30312 -10.66795 1.000 10.79869  ? 136 ARG A CA  1 
ATOM   1068 C C   . ARG A 1 136 ? -26.97811 19.60301 -10.16381 1.000 10.96869  ? 136 ARG A C   1 
ATOM   1069 O O   . ARG A 1 136 ? -27.26957 19.73037 -8.96640  1.000 10.54869  ? 136 ARG A O   1 
ATOM   1070 C CB  . ARG A 1 136 ? -24.85144 18.45390 -10.92254 1.000 12.55869  ? 136 ARG A CB  1 
ATOM   1071 C CG  . ARG A 1 136 ? -24.00126 18.81334 -9.68762  1.000 14.60869  ? 136 ARG A CG  1 
ATOM   1072 C CD  . ARG A 1 136 ? -22.51374 18.70530 -10.03095 1.000 16.66869  ? 136 ARG A CD  1 
ATOM   1073 N NE  . ARG A 1 136 ? -21.67287 19.02950 -8.88473  1.000 21.19869  ? 136 ARG A NE  1 
ATOM   1074 C CZ  . ARG A 1 136 ? -21.08869 20.20540 -8.70130  1.000 24.38869  ? 136 ARG A CZ  1 
ATOM   1075 N NH1 . ARG A 1 136 ? -21.22495 21.18510 -9.57432  1.000 25.00869  ? 136 ARG A NH1 1 
ATOM   1076 N NH2 . ARG A 1 136 ? -20.34643 20.40064 -7.61740  1.000 28.44869  ? 136 ARG A NH2 1 
ATOM   1077 N N   . GLY A 1 137 ? -27.21588 20.56353 -11.06658 1.000 10.23964  ? 137 GLY A N   1 
ATOM   1078 C CA  . GLY A 1 137 ? -27.96531 21.76191 -10.69637 1.000 10.08964  ? 137 GLY A CA  1 
ATOM   1079 C C   . GLY A 1 137 ? -29.38662 21.46749 -10.24058 1.000 11.62964  ? 137 GLY A C   1 
ATOM   1080 O O   . GLY A 1 137 ? -29.87147 22.05024 -9.26291  1.000 11.33964  ? 137 GLY A O   1 
ATOM   1081 N N   . LEU A 1 138 ? -30.06700 20.53605 -10.91876 1.000 10.88970  ? 138 LEU A N   1 
ATOM   1082 C CA  . LEU A 1 138 ? -31.44828 20.22149 -10.54409 1.000 11.29970  ? 138 LEU A CA  1 
ATOM   1083 C C   . LEU A 1 138 ? -31.53464 19.53364 -9.19119  1.000 10.17970  ? 138 LEU A C   1 
ATOM   1084 O O   . LEU A 1 138 ? -32.50776 19.74531 -8.45404  1.000 11.18970  ? 138 LEU A O   1 
ATOM   1085 C CB  . LEU A 1 138 ? -32.10934 19.32729 -11.59095 1.000 11.16970  ? 138 LEU A CB  1 
ATOM   1086 C CG  . LEU A 1 138 ? -32.53054 19.96112 -12.90502 1.000 13.65970  ? 138 LEU A CG  1 
ATOM   1087 C CD1 . LEU A 1 138 ? -33.22017 18.87680 -13.72321 1.000 16.00970  ? 138 LEU A CD1 1 
ATOM   1088 C CD2 . LEU A 1 138 ? -33.47201 21.11423 -12.63582 1.000 14.95970  ? 138 LEU A CD2 1 
ATOM   1089 N N   . LYS A 1 139 ? -30.58553 18.64750 -8.88018  1.000 10.82337  ? 139 LYS A N   1 
ATOM   1090 C CA  . LYS A 1 139 ? -30.55845 18.04030 -7.54498  1.000 11.43337  ? 139 LYS A CA  1 
ATOM   1091 C C   . LYS A 1 139 ? -30.52644 19.11582 -6.46501  1.000 11.78337  ? 139 LYS A C   1 
ATOM   1092 O O   . LYS A 1 139 ? -31.25983 19.03615 -5.46532  1.000 12.41337  ? 139 LYS A O   1 
ATOM   1093 C CB  . LYS A 1 139 ? -29.35138 17.11100 -7.39965  1.000 12.18337  ? 139 LYS A CB  1 
ATOM   1094 C CG  . LYS A 1 139 ? -29.27252 16.46718 -6.01900  1.000 13.34337  ? 139 LYS A CG  1 
ATOM   1095 C CD  . LYS A 1 139 ? -27.92104 15.81030 -5.72380  1.000 14.45337  ? 139 LYS A CD  1 
ATOM   1096 C CE  . LYS A 1 139 ? -27.93217 15.23548 -4.30136  1.000 14.96337  ? 139 LYS A CE  1 
ATOM   1097 N NZ  . LYS A 1 139 ? -26.64932 14.57413 -3.93106  1.000 16.26337  ? 139 LYS A NZ  1 
ATOM   1098 N N   . TYR A 1 140 ? -29.72649 20.15520 -6.69355  1.000 12.43830  ? 140 TYR A N   1 
ATOM   1099 C CA  . TYR A 1 140 ? -29.64516 21.27784 -5.76179  1.000 12.20830  ? 140 TYR A CA  1 
ATOM   1100 C C   . TYR A 1 140 ? -30.97378 22.01584 -5.67544  1.000 12.00830  ? 140 TYR A C   1 
ATOM   1101 O O   . TYR A 1 140 ? -31.50810 22.21644 -4.58043  1.000 13.03830  ? 140 TYR A O   1 
ATOM   1102 C CB  . TYR A 1 140 ? -28.52618 22.21804 -6.20144  1.000 12.27830  ? 140 TYR A CB  1 
ATOM   1103 C CG  . TYR A 1 140 ? -28.40076 23.48796 -5.37757  1.000 12.57830  ? 140 TYR A CG  1 
ATOM   1104 C CD1 . TYR A 1 140 ? -27.64907 23.50063 -4.19633  1.000 13.00830  ? 140 TYR A CD1 1 
ATOM   1105 C CD2 . TYR A 1 140 ? -29.02981 24.67335 -5.77751  1.000 11.25830  ? 140 TYR A CD2 1 
ATOM   1106 C CE1 . TYR A 1 140 ? -27.50305 24.67224 -3.45595  1.000 12.64830  ? 140 TYR A CE1 1 
ATOM   1107 C CE2 . TYR A 1 140 ? -28.93161 25.84322 -5.01656  1.000 12.31830  ? 140 TYR A CE2 1 
ATOM   1108 C CZ  . TYR A 1 140 ? -28.17463 25.83061 -3.84923  1.000 13.47830  ? 140 TYR A CZ  1 
ATOM   1109 O OH  . TYR A 1 140 ? -28.04035 26.99044 -3.09851  1.000 16.20830  ? 140 TYR A OH  1 
ATOM   1110 N N   . ILE A 1 141 ? -31.51327 22.41861 -6.83016  1.000 11.01873  ? 141 ILE A N   1 
ATOM   1111 C CA  . ILE A 1 141 ? -32.79544 23.12449 -6.91879  1.000 14.46873  ? 141 ILE A CA  1 
ATOM   1112 C C   . ILE A 1 141 ? -33.89829 22.32929 -6.23026  1.000 13.43873  ? 141 ILE A C   1 
ATOM   1113 O O   . ILE A 1 141 ? -34.63886 22.84496 -5.37571  1.000 13.06873  ? 141 ILE A O   1 
ATOM   1114 C CB  . ILE A 1 141 ? -33.15738 23.36573 -8.40169  1.000 20.32873  ? 141 ILE A CB  1 
ATOM   1115 C CG1 . ILE A 1 141 ? -32.12207 24.21434 -9.12741  1.000 28.41873  ? 141 ILE A CG1 1 
ATOM   1116 C CG2 . ILE A 1 141 ? -34.45916 24.04269 -8.54241  1.000 23.88873  ? 141 ILE A CG2 1 
ATOM   1117 C CD1 . ILE A 1 141 ? -31.79968 25.40469 -8.41967  1.000 35.27873  ? 141 ILE A CD1 1 
ATOM   1118 N N   . HIS A 1 142 ? -34.04248 21.06616 -6.62269  1.000 13.72905  ? 142 HIS A N   1 
ATOM   1119 C CA  . HIS A 1 142 ? -35.15423 20.25756 -6.12919  1.000 14.26905  ? 142 HIS A CA  1 
ATOM   1120 C C   . HIS A 1 142 ? -35.03476 19.98740 -4.63562  1.000 15.15905  ? 142 HIS A C   1 
ATOM   1121 O O   . HIS A 1 142 ? -36.05491 19.81784 -3.96167  1.000 15.37905  ? 142 HIS A O   1 
ATOM   1122 C CB  . HIS A 1 142 ? -35.22871 18.94354 -6.90202  1.000 13.37905  ? 142 HIS A CB  1 
ATOM   1123 C CG  . HIS A 1 142 ? -35.62974 19.10747 -8.33757  1.000 14.61905  ? 142 HIS A CG  1 
ATOM   1124 N ND1 . HIS A 1 142 ? -35.65082 18.05265 -9.22947  1.000 15.43905  ? 142 HIS A ND1 1 
ATOM   1125 C CD2 . HIS A 1 142 ? -36.03902 20.19918 -9.03143  1.000 14.28905  ? 142 HIS A CD2 1 
ATOM   1126 C CE1 . HIS A 1 142 ? -36.04237 18.49020 -10.41109 1.000 13.87905  ? 142 HIS A CE1 1 
ATOM   1127 N NE2 . HIS A 1 142 ? -36.29565 19.78533 -10.31426 1.000 15.63905  ? 142 HIS A NE2 1 
ATOM   1128 N N   . SER A 1 143 ? -33.80722 19.96360 -4.10676  1.000 15.82559  ? 143 SER A N   1 
ATOM   1129 C CA  . SER A 1 143 ? -33.60360 19.75152 -2.67964  1.000 16.88559  ? 143 SER A CA  1 
ATOM   1130 C C   . SER A 1 143 ? -34.12042 20.91657 -1.85087  1.000 20.17559  ? 143 SER A C   1 
ATOM   1131 O O   . SER A 1 143 ? -34.39771 20.73355 -0.66305  1.000 20.03559  ? 143 SER A O   1 
ATOM   1132 C CB  . SER A 1 143 ? -32.12392 19.52601 -2.37068  1.000 16.30559  ? 143 SER A CB  1 
ATOM   1133 O OG  . SER A 1 143 ? -31.38024 20.71496 -2.57603  1.000 14.65559  ? 143 SER A OG  1 
ATOM   1134 N N   . ALA A 1 144 ? -34.27333 22.09717 -2.44559  1.000 18.16562  ? 144 ALA A N   1 
ATOM   1135 C CA  . ALA A 1 144 ? -34.88899 23.22902 -1.76337  1.000 20.51562  ? 144 ALA A CA  1 
ATOM   1136 C C   . ALA A 1 144 ? -36.38595 23.34263 -2.04160  1.000 21.38562  ? 144 ALA A C   1 
ATOM   1137 O O   . ALA A 1 144 ? -36.98011 24.37544 -1.70881  1.000 26.56562  ? 144 ALA A O   1 
ATOM   1138 C CB  . ALA A 1 144 ? -34.19074 24.53060 -2.16234  1.000 19.00562  ? 144 ALA A CB  1 
ATOM   1139 N N   . ASP A 1 145 ? -36.99757 22.30542 -2.63180  1.000 20.43439  ? 145 ASP A N   1 
ATOM   1140 C CA  . ASP A 1 145 ? -38.40211 22.30759 -3.07272  1.000 24.12439  ? 145 ASP A CA  1 
ATOM   1141 C C   . ASP A 1 145 ? -38.67358 23.42720 -4.06554  1.000 23.55439  ? 145 ASP A C   1 
ATOM   1142 O O   . ASP A 1 145 ? -39.75297 24.02235 -4.07101  1.000 23.55439  ? 145 ASP A O   1 
ATOM   1143 C CB  . ASP A 1 145 ? -39.39345 22.39875 -1.90424  1.000 30.04439  ? 145 ASP A CB  1 
ATOM   1144 C CG  . ASP A 1 145 ? -39.14575 21.34882 -0.83501  1.000 40.68439  ? 145 ASP A CG  1 
ATOM   1145 O OD1 . ASP A 1 145 ? -38.85961 20.18376 -1.18691  1.000 44.43439  ? 145 ASP A OD1 1 
ATOM   1146 O OD2 . ASP A 1 145 ? -39.24236 21.69507 0.36360   1.000 61.83439  ? 145 ASP A OD2 1 
ATOM   1147 N N   . ILE A 1 146 ? -37.68971 23.73240 -4.89655  1.000 17.51675  ? 146 ILE A N   1 
ATOM   1148 C CA  . ILE A 1 146 ? -37.86708 24.63309 -6.02011  1.000 18.86675  ? 146 ILE A CA  1 
ATOM   1149 C C   . ILE A 1 146 ? -38.01210 23.78023 -7.27510  1.000 23.73675  ? 146 ILE A C   1 
ATOM   1150 O O   . ILE A 1 146 ? -37.35386 22.74493 -7.41684  1.000 22.95675  ? 146 ILE A O   1 
ATOM   1151 C CB  . ILE A 1 146 ? -36.69111 25.62468 -6.10850  1.000 17.46675  ? 146 ILE A CB  1 
ATOM   1152 C CG1 . ILE A 1 146 ? -36.65943 26.49350 -4.84097  1.000 20.96675  ? 146 ILE A CG1 1 
ATOM   1153 C CG2 . ILE A 1 146 ? -36.79106 26.49914 -7.37648  1.000 21.34675  ? 146 ILE A CG2 1 
ATOM   1154 C CD1 . ILE A 1 146 ? -35.32746 27.16643 -4.57348  1.000 24.28675  ? 146 ILE A CD1 1 
ATOM   1155 N N   . ILE A 1 147 ? -38.93821 24.16537 -8.14502  1.000 22.21717  ? 147 ILE A N   1 
ATOM   1156 C CA  . ILE A 1 147 ? -39.10230 23.56496 -9.45854  1.000 24.89717  ? 147 ILE A CA  1 
ATOM   1157 C C   . ILE A 1 147 ? -38.77132 24.63730 -10.48318 1.000 23.94717  ? 147 ILE A C   1 
ATOM   1158 O O   . ILE A 1 147 ? -39.18871 25.79083 -10.33459 1.000 25.07717  ? 147 ILE A O   1 
ATOM   1159 C CB  . ILE A 1 147 ? -40.53772 23.02743 -9.64913  1.000 27.49717  ? 147 ILE A CB  1 
ATOM   1160 C CG1 . ILE A 1 147 ? -40.94761 22.16040 -8.45200  1.000 32.50717  ? 147 ILE A CG1 1 
ATOM   1161 C CG2 . ILE A 1 147 ? -40.65097 22.24811 -10.93429 1.000 28.12717  ? 147 ILE A CG2 1 
ATOM   1162 C CD1 . ILE A 1 147 ? -42.40961 21.68405 -8.48531  1.000 32.97717  ? 147 ILE A CD1 1 
ATOM   1163 N N   . HIS A 1 148 ? -38.01538 24.27487 -11.51684 1.000 22.86066  ? 148 HIS A N   1 
ATOM   1164 C CA  . HIS A 1 148 ? -37.70411 25.27281 -12.52955 1.000 22.33066  ? 148 HIS A CA  1 
ATOM   1165 C C   . HIS A 1 148 ? -38.93001 25.59741 -13.37646 1.000 21.67066  ? 148 HIS A C   1 
ATOM   1166 O O   . HIS A 1 148 ? -39.24467 26.77351 -13.59573 1.000 20.53066  ? 148 HIS A O   1 
ATOM   1167 C CB  . HIS A 1 148 ? -36.55610 24.80647 -13.41158 1.000 21.83066  ? 148 HIS A CB  1 
ATOM   1168 C CG  . HIS A 1 148 ? -36.06644 25.85759 -14.35618 1.000 20.82066  ? 148 HIS A CG  1 
ATOM   1169 N ND1 . HIS A 1 148 ? -36.74664 26.20941 -15.50226 1.000 19.79066  ? 148 HIS A ND1 1 
ATOM   1170 C CD2 . HIS A 1 148 ? -34.95565 26.63076 -14.32658 1.000 21.87066  ? 148 HIS A CD2 1 
ATOM   1171 C CE1 . HIS A 1 148 ? -36.07773 27.15503 -16.13781 1.000 24.19066  ? 148 HIS A CE1 1 
ATOM   1172 N NE2 . HIS A 1 148 ? -34.98082 27.42040 -15.44956 1.000 22.61066  ? 148 HIS A NE2 1 
ATOM   1173 N N   . ARG A 1 149 ? -39.60054 24.56331 -13.89032 1.000 17.23884  ? 149 ARG A N   1 
ATOM   1174 C CA  . ARG A 1 149 ? -40.83155 24.52492 -14.68336 1.000 22.64884  ? 149 ARG A CA  1 
ATOM   1175 C C   . ARG A 1 149 ? -40.65034 24.93022 -16.14866 1.000 21.83884  ? 149 ARG A C   1 
ATOM   1176 O O   . ARG A 1 149 ? -41.58193 24.73314 -16.93425 1.000 20.41884  ? 149 ARG A O   1 
ATOM   1177 C CB  . ARG A 1 149 ? -41.97615 25.37726 -14.09914 1.000 28.33884  ? 149 ARG A CB  1 
ATOM   1178 C CG  . ARG A 1 149 ? -42.53476 24.88956 -12.78474 1.000 39.26884  ? 149 ARG A CG  1 
ATOM   1179 C CD  . ARG A 1 149 ? -43.50686 25.91257 -12.19045 1.000 55.09884  ? 149 ARG A CD  1 
ATOM   1180 N NE  . ARG A 1 149 ? -42.86764 27.20250 -11.94270 1.000 70.91884  ? 149 ARG A NE  1 
ATOM   1181 C CZ  . ARG A 1 149 ? -42.29833 27.55650 -10.79686 1.000 78.60884  ? 149 ARG A CZ  1 
ATOM   1182 N NH1 . ARG A 1 149 ? -42.28424 26.74523 -9.75122  1.000 74.02884  ? 149 ARG A NH1 1 
ATOM   1183 N NH2 . ARG A 1 149 ? -41.72574 28.75420 -10.69892 1.000 85.66884  ? 149 ARG A NH2 1 
ATOM   1184 N N   . ASP A 1 150 ? -39.50629 25.47663 -16.55809 1.000 20.80002  ? 150 ASP A N   1 
ATOM   1185 C CA  . ASP A 1 150 ? -39.36555 25.92902 -17.94218 1.000 23.73002  ? 150 ASP A CA  1 
ATOM   1186 C C   . ASP A 1 150 ? -37.97750 25.61121 -18.48469 1.000 21.19002  ? 150 ASP A C   1 
ATOM   1187 O O   . ASP A 1 150 ? -37.35982 26.43274 -19.17141 1.000 20.07002  ? 150 ASP A O   1 
ATOM   1188 C CB  . ASP A 1 150 ? -39.65660 27.42647 -18.06334 1.000 29.36002  ? 150 ASP A CB  1 
ATOM   1189 C CG  . ASP A 1 150 ? -39.96086 27.85568 -19.50076 1.000 37.61002  ? 150 ASP A CG  1 
ATOM   1190 O OD1 . ASP A 1 150 ? -40.42537 27.00950 -20.30593 1.000 37.59002  ? 150 ASP A OD1 1 
ATOM   1191 O OD2 . ASP A 1 150 ? -39.69630 29.03575 -19.82845 1.000 45.61002  ? 150 ASP A OD2 1 
ATOM   1192 N N   . LEU A 1 151 ? -37.46417 24.41678 -18.18163 1.000 17.25722  ? 151 LEU A N   1 
ATOM   1193 C CA  . LEU A 1 151 ? -36.18127 24.00067 -18.73148 1.000 16.26722  ? 151 LEU A CA  1 
ATOM   1194 C C   . LEU A 1 151 ? -36.29735 23.79764 -20.22487 1.000 15.04722  ? 151 LEU A C   1 
ATOM   1195 O O   . LEU A 1 151 ? -37.19895 23.09943 -20.70199 1.000 18.92722  ? 151 LEU A O   1 
ATOM   1196 C CB  . LEU A 1 151 ? -35.70348 22.70047 -18.09814 1.000 17.30722  ? 151 LEU A CB  1 
ATOM   1197 C CG  . LEU A 1 151 ? -35.05553 22.70595 -16.73880 1.000 23.15722  ? 151 LEU A CG  1 
ATOM   1198 C CD1 . LEU A 1 151 ? -34.61852 21.28167 -16.44166 1.000 25.95722  ? 151 LEU A CD1 1 
ATOM   1199 C CD2 . LEU A 1 151 ? -33.85537 23.67237 -16.72558 1.000 26.25722  ? 151 LEU A CD2 1 
ATOM   1200 N N   . LYS A 1 152 ? -35.36757 24.38603 -20.95722 1.000 15.74492  ? 152 LYS A N   1 
ATOM   1201 C CA  . LYS A 1 152 ? -35.27241 24.24026 -22.39871 1.000 16.65492  ? 152 LYS A CA  1 
ATOM   1202 C C   . LYS A 1 152 ? -33.88066 24.68989 -22.78761 1.000 13.39492  ? 152 LYS A C   1 
ATOM   1203 O O   . LYS A 1 152 ? -33.17244 25.25302 -21.94115 1.000 15.12492  ? 152 LYS A O   1 
ATOM   1204 C CB  . LYS A 1 152 ? -36.37636 25.05305 -23.11185 1.000 19.51492  ? 152 LYS A CB  1 
ATOM   1205 C CG  . LYS A 1 152 ? -36.45832 26.49614 -22.75191 1.000 22.87492  ? 152 LYS A CG  1 
ATOM   1206 C CD  . LYS A 1 152 ? -37.72239 27.06914 -23.34509 1.000 28.01492  ? 152 LYS A CD  1 
ATOM   1207 C CE  . LYS A 1 152 ? -37.68747 28.56950 -23.35391 1.000 32.10492  ? 152 LYS A CE  1 
ATOM   1208 N NZ  . LYS A 1 152 ? -38.00910 29.08639 -22.00725 1.000 44.08492  ? 152 LYS A NZ  1 
ATOM   1209 N N   . PRO A 1 153 ? -33.41766 24.39550 -24.01707 1.000 14.20484  ? 153 PRO A N   1 
ATOM   1210 C CA  . PRO A 1 153 ? -32.01911 24.72052 -24.34626 1.000 17.12484  ? 153 PRO A CA  1 
ATOM   1211 C C   . PRO A 1 153 ? -31.66473 26.19287 -24.23160 1.000 17.94484  ? 153 PRO A C   1 
ATOM   1212 O O   . PRO A 1 153 ? -30.51582 26.49475 -23.88975 1.000 16.62484  ? 153 PRO A O   1 
ATOM   1213 C CB  . PRO A 1 153 ? -31.87154 24.21444 -25.78710 1.000 18.20484  ? 153 PRO A CB  1 
ATOM   1214 C CG  . PRO A 1 153 ? -32.78980 23.04417 -25.83249 1.000 18.28484  ? 153 PRO A CG  1 
ATOM   1215 C CD  . PRO A 1 153 ? -33.98956 23.49229 -25.03651 1.000 18.98484  ? 153 PRO A CD  1 
ATOM   1216 N N   . SER A 1 154 ? -32.61120 27.11083 -24.46361 1.000 15.72112  ? 154 SER A N   1 
ATOM   1217 C CA  . SER A 1 154 ? -32.29511 28.53303 -24.33939 1.000 19.25112  ? 154 SER A CA  1 
ATOM   1218 C C   . SER A 1 154 ? -32.16537 29.00247 -22.88893 1.000 20.12112  ? 154 SER A C   1 
ATOM   1219 O O   . SER A 1 154 ? -31.73104 30.13951 -22.66417 1.000 22.25112  ? 154 SER A O   1 
ATOM   1220 C CB  . SER A 1 154 ? -33.36326 29.36947 -25.05275 1.000 18.05112  ? 154 SER A CB  1 
ATOM   1221 O OG  . SER A 1 154 ? -34.64083 29.09523 -24.49791 1.000 22.19112  ? 154 SER A OG  1 
ATOM   1222 N N   . ASN A 1 155 ? -32.53827 28.17997 -21.90338 1.000 15.48149  ? 155 ASN A N   1 
ATOM   1223 C CA  . ASN A 1 155 ? -32.35630 28.50668 -20.49437 1.000 16.80149  ? 155 ASN A CA  1 
ATOM   1224 C C   . ASN A 1 155 ? -31.13171 27.83395 -19.90252 1.000 15.67149  ? 155 ASN A C   1 
ATOM   1225 O O   . ASN A 1 155 ? -31.01980 27.73603 -18.67724 1.000 17.98149  ? 155 ASN A O   1 
ATOM   1226 C CB  . ASN A 1 155 ? -33.58797 28.12119 -19.68384 1.000 19.85149  ? 155 ASN A CB  1 
ATOM   1227 C CG  . ASN A 1 155 ? -34.68144 29.15071 -19.78690 1.000 29.58149  ? 155 ASN A CG  1 
ATOM   1228 O OD1 . ASN A 1 155 ? -34.42731 30.29980 -20.16875 1.000 32.71149  ? 155 ASN A OD1 1 
ATOM   1229 N ND2 . ASN A 1 155 ? -35.91209 28.75443 -19.46153 1.000 28.27149  ? 155 ASN A ND2 1 
ATOM   1230 N N   . LEU A 1 156 ? -30.24181 27.32200 -20.74501 1.000 12.77982  ? 156 LEU A N   1 
ATOM   1231 C CA  . LEU A 1 156 ? -29.03942 26.63476 -20.29870 1.000 13.59982  ? 156 LEU A CA  1 
ATOM   1232 C C   . LEU A 1 156 ? -27.84897 27.31294 -20.95144 1.000 17.18982  ? 156 LEU A C   1 
ATOM   1233 O O   . LEU A 1 156 ? -27.72194 27.29420 -22.17781 1.000 20.14982  ? 156 LEU A O   1 
ATOM   1234 C CB  . LEU A 1 156 ? -29.09059 25.14941 -20.66458 1.000 15.68982  ? 156 LEU A CB  1 
ATOM   1235 C CG  . LEU A 1 156 ? -30.29363 24.39597 -20.07685 1.000 16.10982  ? 156 LEU A CG  1 
ATOM   1236 C CD1 . LEU A 1 156 ? -30.47227 23.04079 -20.76243 1.000 20.88982  ? 156 LEU A CD1 1 
ATOM   1237 C CD2 . LEU A 1 156 ? -30.18442 24.23697 -18.56434 1.000 15.06982  ? 156 LEU A CD2 1 
ATOM   1238 N N   . ALA A 1 157 ? -26.98941 27.91092 -20.14094 1.000 15.55749  ? 157 ALA A N   1 
ATOM   1239 C CA  . ALA A 1 157 ? -25.82780 28.64394 -20.61803 1.000 18.08749  ? 157 ALA A CA  1 
ATOM   1240 C C   . ALA A 1 157 ? -24.58731 27.77042 -20.54105 1.000 17.72749  ? 157 ALA A C   1 
ATOM   1241 O O   . ALA A 1 157 ? -24.38754 27.06561 -19.55940 1.000 18.21749  ? 157 ALA A O   1 
ATOM   1242 C CB  . ALA A 1 157 ? -25.62346 29.88062 -19.76738 1.000 22.07749  ? 157 ALA A CB  1 
ATOM   1243 N N   . VAL A 1 158 ? -23.75259 27.81900 -21.57730 1.000 15.58752  ? 158 VAL A N   1 
ATOM   1244 C CA  . VAL A 1 158 ? -22.57434 26.96371 -21.69246 1.000 19.93752  ? 158 VAL A CA  1 
ATOM   1245 C C   . VAL A 1 158 ? -21.40001 27.83252 -22.12098 1.000 21.92752  ? 158 VAL A C   1 
ATOM   1246 O O   . VAL A 1 158 ? -21.56632 28.70300 -22.98325 1.000 22.01752  ? 158 VAL A O   1 
ATOM   1247 C CB  . VAL A 1 158 ? -22.79830 25.81858 -22.71502 1.000 20.65752  ? 158 VAL A CB  1 
ATOM   1248 C CG1 . VAL A 1 158 ? -21.57878 24.92726 -22.80037 1.000 23.61752  ? 158 VAL A CG1 1 
ATOM   1249 C CG2 . VAL A 1 158 ? -24.03721 24.97552 -22.34823 1.000 21.62752  ? 158 VAL A CG2 1 
ATOM   1250 N N   . ASN A 1 159 ? -20.21587 27.60577 -21.52550 1.000 23.68324  ? 159 ASN A N   1 
ATOM   1251 C CA  . ASN A 1 159 ? -19.01602 28.33600 -21.92445 1.000 26.53324  ? 159 ASN A CA  1 
ATOM   1252 C C   . ASN A 1 159 ? -18.11575 27.44958 -22.78795 1.000 28.02324  ? 159 ASN A C   1 
ATOM   1253 O O   . ASN A 1 159 ? -18.45022 26.30729 -23.11994 1.000 24.91324  ? 159 ASN A O   1 
ATOM   1254 C CB  . ASN A 1 159 ? -18.26608 28.92631 -20.70510 1.000 25.57324  ? 159 ASN A CB  1 
ATOM   1255 C CG  . ASN A 1 159 ? -17.71159 27.86780 -19.71496 1.000 30.83324  ? 159 ASN A CG  1 
ATOM   1256 O OD1 . ASN A 1 159 ? -17.39386 26.72868 -20.06680 1.000 31.04324  ? 159 ASN A OD1 1 
ATOM   1257 N ND2 . ASN A 1 159 ? -17.56870 28.28146 -18.45665 1.000 30.53324  ? 159 ASN A ND2 1 
ATOM   1258 N N   . GLU A 1 160 ? -16.94044 27.98690 -23.14053 1.000 29.19609  ? 160 GLU A N   1 
ATOM   1259 C CA  . GLU A 1 160 ? -16.01064 27.27757 -24.01560 1.000 34.56609  ? 160 GLU A CA  1 
ATOM   1260 C C   . GLU A 1 160 ? -15.39808 26.05711 -23.34701 1.000 29.11609  ? 160 GLU A C   1 
ATOM   1261 O O   . GLU A 1 160 ? -14.85261 25.19798 -24.04559 1.000 30.60609  ? 160 GLU A O   1 
ATOM   1262 C CB  . GLU A 1 160 ? -14.89806 28.21860 -24.49647 1.000 42.54609  ? 160 GLU A CB  1 
ATOM   1263 C CG  . GLU A 1 160 ? -15.39086 29.35450 -25.40166 1.000 53.35609  ? 160 GLU A CG  1 
ATOM   1264 C CD  . GLU A 1 160 ? -14.26983 30.05700 -26.16905 1.000 68.83609  ? 160 GLU A CD  1 
ATOM   1265 O OE1 . GLU A 1 160 ? -13.07976 29.74180 -25.93299 1.000 68.47609  ? 160 GLU A OE1 1 
ATOM   1266 O OE2 . GLU A 1 160 ? -14.58717 30.92323 -27.01799 1.000 78.29609  ? 160 GLU A OE2 1 
ATOM   1267 N N   . ASP A 1 161 ? -15.48287 25.94939 -22.02181 1.000 25.86825  ? 161 ASP A N   1 
ATOM   1268 C CA  . ASP A 1 161 ? -15.02700 24.76668 -21.30624 1.000 26.44825  ? 161 ASP A CA  1 
ATOM   1269 C C   . ASP A 1 161 ? -16.12182 23.72283 -21.13112 1.000 23.53825  ? 161 ASP A C   1 
ATOM   1270 O O   . ASP A 1 161 ? -15.92748 22.77751 -20.36055 1.000 23.41825  ? 161 ASP A O   1 
ATOM   1271 C CB  . ASP A 1 161 ? -14.47510 25.15488 -19.93077 1.000 32.78825  ? 161 ASP A CB  1 
ATOM   1272 C CG  . ASP A 1 161 ? -13.17729 25.95341 -20.01940 1.000 40.52825  ? 161 ASP A CG  1 
ATOM   1273 O OD1 . ASP A 1 161 ? -12.26155 25.53246 -20.75792 1.000 45.66825  ? 161 ASP A OD1 1 
ATOM   1274 O OD2 . ASP A 1 161 ? -13.08259 27.00872 -19.35458 1.000 52.95825  ? 161 ASP A OD2 1 
ATOM   1275 N N   . CYS A 1 162 ? -17.26424 23.88873 -21.81165 1.000 23.87246  ? 162 CYS A N   1 
ATOM   1276 C CA  . CYS A 1 162 ? -18.43204 23.00924 -21.70796 1.000 23.46246  ? 162 CYS A CA  1 
ATOM   1277 C C   . CYS A 1 162 ? -19.03410 23.01408 -20.29593 1.000 23.74246  ? 162 CYS A C   1 
ATOM   1278 O O   . CYS A 1 162 ? -19.70780 22.05499 -19.89883 1.000 19.92246  ? 162 CYS A O   1 
ATOM   1279 C CB  . CYS A 1 162 ? -18.09078 21.57410 -22.16486 1.000 26.46246  ? 162 CYS A CB  1 
ATOM   1280 S SG  . CYS A 1 162 ? -19.46896 20.51517 -22.66733 1.000 26.66246  ? 162 CYS A SG  1 
ATOM   1281 N N   . GLU A 1 163 ? -18.80715 24.08512 -19.52895 1.000 21.25364  ? 163 GLU A N   1 
ATOM   1282 C CA  . GLU A 1 163 ? -19.39127 24.23793 -18.20014 1.000 23.73364  ? 163 GLU A CA  1 
ATOM   1283 C C   . GLU A 1 163 ? -20.75334 24.90620 -18.32358 1.000 19.06364  ? 163 GLU A C   1 
ATOM   1284 O O   . GLU A 1 163 ? -20.92746 25.83251 -19.11700 1.000 21.37364  ? 163 GLU A O   1 
ATOM   1285 C CB  . GLU A 1 163 ? -18.46866 25.06392 -17.29886 1.000 25.30364  ? 163 GLU A CB  1 
ATOM   1286 C CG  . GLU A 1 163 ? -17.12427 24.38305 -17.04985 1.000 32.71364  ? 163 GLU A CG  1 
ATOM   1287 C CD  . GLU A 1 163 ? -16.11411 25.27176 -16.32191 1.000 40.54364  ? 163 GLU A CD  1 
ATOM   1288 O OE1 . GLU A 1 163 ? -16.15158 26.50966 -16.50304 1.000 42.90364  ? 163 GLU A OE1 1 
ATOM   1289 O OE2 . GLU A 1 163 ? -15.27846 24.71942 -15.57145 1.000 44.52364  ? 163 GLU A OE2 1 
ATOM   1290 N N   . LEU A 1 164 ? -21.72300 24.42755 -17.54721 1.000 16.03164  ? 164 LEU A N   1 
ATOM   1291 C CA  . LEU A 1 164 ? -23.11593 24.78880 -17.76359 1.000 13.42164  ? 164 LEU A CA  1 
ATOM   1292 C C   . LEU A 1 164 ? -23.74212 25.40866 -16.51772 1.000 12.20164  ? 164 LEU A C   1 
ATOM   1293 O O   . LEU A 1 164 ? -23.47378 24.98332 -15.39184 1.000 12.13164  ? 164 LEU A O   1 
ATOM   1294 C CB  . LEU A 1 164 ? -23.93192 23.55060 -18.18590 1.000 14.03164  ? 164 LEU A CB  1 
ATOM   1295 C CG  . LEU A 1 164 ? -25.44629 23.66359 -18.40301 1.000 9.87164   ? 164 LEU A CG  1 
ATOM   1296 C CD1 . LEU A 1 164 ? -25.84596 22.72347 -19.51302 1.000 11.35164  ? 164 LEU A CD1 1 
ATOM   1297 C CD2 . LEU A 1 164 ? -26.21138 23.30272 -17.13390 1.000 10.61164  ? 164 LEU A CD2 1 
ATOM   1298 N N   . LYS A 1 165 ? -24.65911 26.34841 -16.74657 1.000 12.26381  ? 165 LYS A N   1 
ATOM   1299 C CA  . LYS A 1 165 ? -25.49533 26.93769 -15.70481 1.000 13.64381  ? 165 LYS A CA  1 
ATOM   1300 C C   . LYS A 1 165 ? -26.94915 26.96497 -16.14979 1.000 11.16381  ? 165 LYS A C   1 
ATOM   1301 O O   . LYS A 1 165 ? -27.24873 27.33714 -17.28825 1.000 12.07381  ? 165 LYS A O   1 
ATOM   1302 C CB  . LYS A 1 165 ? -25.07073 28.37727 -15.38736 1.000 16.89381  ? 165 LYS A CB  1 
ATOM   1303 C CG  . LYS A 1 165 ? -23.83368 28.49801 -14.52598 1.000 23.03381  ? 165 LYS A CG  1 
ATOM   1304 C CD  . LYS A 1 165 ? -23.66328 29.95515 -14.06486 1.000 24.69381  ? 165 LYS A CD  1 
ATOM   1305 C CE  . LYS A 1 165 ? -22.23750 30.21274 -13.60771 1.000 26.98381  ? 165 LYS A CE  1 
ATOM   1306 N NZ  . LYS A 1 165 ? -21.87550 29.28071 -12.52568 1.000 29.51381  ? 165 LYS A NZ  1 
ATOM   1307 N N   . ILE A 1 166 ? -27.84433 26.61038 -15.22985 1.000 12.59792  ? 166 ILE A N   1 
ATOM   1308 C CA  . ILE A 1 166 ? -29.28437 26.74089 -15.43020 1.000 12.03792  ? 166 ILE A CA  1 
ATOM   1309 C C   . ILE A 1 166 ? -29.69572 28.18238 -15.15895 1.000 14.97792  ? 166 ILE A C   1 
ATOM   1310 O O   . ILE A 1 166 ? -29.44247 28.71482 -14.07003 1.000 12.28792  ? 166 ILE A O   1 
ATOM   1311 C CB  . ILE A 1 166 ? -30.04002 25.79159 -14.48937 1.000 12.86792  ? 166 ILE A CB  1 
ATOM   1312 C CG1 . ILE A 1 166 ? -29.61802 24.33134 -14.73113 1.000 12.26792  ? 166 ILE A CG1 1 
ATOM   1313 C CG2 . ILE A 1 166 ? -31.56117 26.00119 -14.60235 1.000 14.14792  ? 166 ILE A CG2 1 
ATOM   1314 C CD1 . ILE A 1 166 ? -30.19621 23.36590 -13.67896 1.000 12.53792  ? 166 ILE A CD1 1 
ATOM   1315 N N   . LEU A 1 167 ? -30.36478 28.80715 -16.12666 1.000 16.52913  ? 167 LEU A N   1 
ATOM   1316 C CA  . LEU A 1 167 ? -30.83357 30.18786 -16.01107 1.000 19.93913  ? 167 LEU A CA  1 
ATOM   1317 C C   . LEU A 1 167 ? -32.35406 30.26858 -15.93059 1.000 25.79913  ? 167 LEU A C   1 
ATOM   1318 O O   . LEU A 1 167 ? -33.07559 29.30221 -16.20121 1.000 19.96913  ? 167 LEU A O   1 
ATOM   1319 C CB  . LEU A 1 167 ? -30.39332 31.02136 -17.21948 1.000 22.24913  ? 167 LEU A CB  1 
ATOM   1320 C CG  . LEU A 1 167 ? -29.08477 30.71900 -17.93233 1.000 27.03913  ? 167 LEU A CG  1 
ATOM   1321 C CD1 . LEU A 1 167 ? -29.12784 31.20769 -19.38039 1.000 33.32913  ? 167 LEU A CD1 1 
ATOM   1322 C CD2 . LEU A 1 167 ? -27.95769 31.36202 -17.17309 1.000 29.02913  ? 167 LEU A CD2 1 
ATOM   1323 N N   . ASP A 1 168 ? -32.81924 31.47435 -15.57741 1.000 24.69764  ? 168 ASP A N   1 
ATOM   1324 C CA  . ASP A 1 168 ? -34.12671 32.02474 -15.96572 1.000 34.66764  ? 168 ASP A CA  1 
ATOM   1325 C C   . ASP A 1 168 ? -35.28230 31.17791 -15.43192 1.000 39.39764  ? 168 ASP A C   1 
ATOM   1326 O O   . ASP A 1 168 ? -36.06132 30.59134 -16.18944 1.000 43.40764  ? 168 ASP A O   1 
ATOM   1327 C CB  . ASP A 1 168 ? -34.25033 32.16005 -17.49334 1.000 40.52764  ? 168 ASP A CB  1 
ATOM   1328 C CG  . ASP A 1 168 ? -33.52846 33.37867 -18.04733 1.000 58.96764  ? 168 ASP A CG  1 
ATOM   1329 O OD1 . ASP A 1 168 ? -33.03826 34.20506 -17.24386 1.000 85.76764  ? 168 ASP A OD1 1 
ATOM   1330 O OD2 . ASP A 1 168 ? -33.45419 33.50766 -19.29411 1.000 52.53764  ? 168 ASP A OD2 1 
ATOM   1331 N N   . PHE A 1 169 ? -35.38698 31.15563 -14.10771 1.000 32.77654  ? 169 PHE A N   1 
ATOM   1332 C CA  . PHE A 1 169 ? -36.40143 30.33615 -13.45433 1.000 38.73654  ? 169 PHE A CA  1 
ATOM   1333 C C   . PHE A 1 169 ? -37.80169 30.87576 -13.72453 1.000 44.94654  ? 169 PHE A C   1 
ATOM   1334 O O   . PHE A 1 169 ? -37.99942 32.07909 -13.91554 1.000 42.90654  ? 169 PHE A O   1 
ATOM   1335 C CB  . PHE A 1 169 ? -36.14371 30.27371 -11.95701 1.000 37.05654  ? 169 PHE A CB  1 
ATOM   1336 C CG  . PHE A 1 169 ? -35.03403 29.34579 -11.58816 1.000 37.15654  ? 169 PHE A CG  1 
ATOM   1337 C CD1 . PHE A 1 169 ? -33.72875 29.59571 -12.01083 1.000 39.76654  ? 169 PHE A CD1 1 
ATOM   1338 C CD2 . PHE A 1 169 ? -35.28773 28.22405 -10.82927 1.000 30.92654  ? 169 PHE A CD2 1 
ATOM   1339 C CE1 . PHE A 1 169 ? -32.70636 28.74623 -11.69450 1.000 38.51654  ? 169 PHE A CE1 1 
ATOM   1340 C CE2 . PHE A 1 169 ? -34.26688 27.36090 -10.51444 1.000 43.47654  ? 169 PHE A CE2 1 
ATOM   1341 C CZ  . PHE A 1 169 ? -32.96672 27.63373 -10.93704 1.000 42.45654  ? 169 PHE A CZ  1 
ATOM   1342 N N   . GLY A 1 170 ? -38.77261 29.96183 -13.74527 1.000 49.05355  ? 170 GLY A N   1 
ATOM   1343 C CA  . GLY A 1 170 ? -40.13598 30.25649 -14.16856 1.000 50.57355  ? 170 GLY A CA  1 
ATOM   1344 C C   . GLY A 1 170 ? -40.87278 31.36413 -13.43321 1.000 51.06355  ? 170 GLY A C   1 
ATOM   1345 O O   . GLY A 1 170 ? -41.35765 31.17503 -12.31923 1.000 51.59355  ? 170 GLY A O   1 
ATOM   1346 N N   . ALA A 1 184 ? -42.02068 26.91298 -28.50468 1.000 40.16346  ? 184 ALA A N   1 
ATOM   1347 C CA  . ALA A 1 184 ? -40.88611 26.01913 -28.36178 1.000 38.00346  ? 184 ALA A CA  1 
ATOM   1348 C C   . ALA A 1 184 ? -40.67609 25.68372 -26.89914 1.000 38.66346  ? 184 ALA A C   1 
ATOM   1349 O O   . ALA A 1 184 ? -40.03583 24.68702 -26.59429 1.000 44.22346  ? 184 ALA A O   1 
ATOM   1350 C CB  . ALA A 1 184 ? -39.63181 26.63296 -28.95722 1.000 43.22346  ? 184 ALA A CB  1 
ATOM   1351 N N   . THR A 1 185 ? -41.20416 26.52168 -25.99574 1.000 45.11238  ? 185 THR A N   1 
ATOM   1352 C CA  . THR A 1 185 ? -41.26878 26.13541 -24.58555 1.000 41.33238  ? 185 THR A CA  1 
ATOM   1353 C C   . THR A 1 185 ? -42.05180 24.84098 -24.42857 1.000 43.48238  ? 185 THR A C   1 
ATOM   1354 O O   . THR A 1 185 ? -41.63769 23.93580 -23.68193 1.000 27.31238  ? 185 THR A O   1 
ATOM   1355 C CB  . THR A 1 185 ? -41.90158 27.25677 -23.74231 1.000 46.20238  ? 185 THR A CB  1 
ATOM   1356 O OG1 . THR A 1 185 ? -40.88173 28.12539 -23.23809 1.000 48.36238  ? 185 THR A OG1 1 
ATOM   1357 C CG2 . THR A 1 185 ? -42.72378 26.71249 -22.55025 1.000 44.44238  ? 185 THR A CG2 1 
ATOM   1358 N N   . ARG A 1 186 ? -43.14419 24.71385 -25.19633 1.000 39.10796  ? 186 ARG A N   1 
ATOM   1359 C CA  . ARG A 1 186 ? -44.04965 23.57867 -25.07667 1.000 35.76796  ? 186 ARG A CA  1 
ATOM   1360 C C   . ARG A 1 186 ? -43.36327 22.26863 -25.42506 1.000 24.37796  ? 186 ARG A C   1 
ATOM   1361 O O   . ARG A 1 186 ? -43.68990 21.22938 -24.83712 1.000 24.80796  ? 186 ARG A O   1 
ATOM   1362 C CB  . ARG A 1 186 ? -45.26492 23.79216 -25.98003 1.000 37.28796  ? 186 ARG A CB  1 
ATOM   1363 C CG  . ARG A 1 186 ? -46.60979 23.63939 -25.26964 1.000 41.65796  ? 186 ARG A CG  1 
ATOM   1364 C CD  . ARG A 1 186 ? -47.71608 23.20499 -26.23166 1.000 39.04796  ? 186 ARG A CD  1 
ATOM   1365 N NE  . ARG A 1 186 ? -47.89586 24.12962 -27.34231 1.000 39.41796  ? 186 ARG A NE  1 
ATOM   1366 C CZ  . ARG A 1 186 ? -47.55145 23.87129 -28.59566 1.000 40.18796  ? 186 ARG A CZ  1 
ATOM   1367 N NH1 . ARG A 1 186 ? -47.01308 22.70578 -28.94170 1.000 28.39796  ? 186 ARG A NH1 1 
ATOM   1368 N NH2 . ARG A 1 186 ? -47.74363 24.80599 -29.52276 1.000 41.29796  ? 186 ARG A NH2 1 
ATOM   1369 N N   . TRP A 1 187 ? -42.39059 22.30618 -26.34646 1.000 19.09589  ? 187 TRP A N   1 
ATOM   1370 C CA  . TRP A 1 187 ? -41.72784 21.09565 -26.80984 1.000 19.94589  ? 187 TRP A CA  1 
ATOM   1371 C C   . TRP A 1 187 ? -40.97385 20.36021 -25.70433 1.000 20.53589  ? 187 TRP A C   1 
ATOM   1372 O O   . TRP A 1 187 ? -40.70443 19.16158 -25.85212 1.000 17.41589  ? 187 TRP A O   1 
ATOM   1373 C CB  . TRP A 1 187 ? -40.75006 21.43084 -27.92656 1.000 18.90589  ? 187 TRP A CB  1 
ATOM   1374 C CG  . TRP A 1 187 ? -41.38893 21.94390 -29.18514 1.000 22.72589  ? 187 TRP A CG  1 
ATOM   1375 C CD1 . TRP A 1 187 ? -42.72132 21.94214 -29.50343 1.000 26.46589  ? 187 TRP A CD1 1 
ATOM   1376 C CD2 . TRP A 1 187 ? -40.70823 22.53485 -30.29549 1.000 20.80589  ? 187 TRP A CD2 1 
ATOM   1377 N NE1 . TRP A 1 187 ? -42.90813 22.49065 -30.76035 1.000 27.31589  ? 187 TRP A NE1 1 
ATOM   1378 C CE2 . TRP A 1 187 ? -41.68622 22.86393 -31.26234 1.000 25.95589  ? 187 TRP A CE2 1 
ATOM   1379 C CE3 . TRP A 1 187 ? -39.36645 22.82626 -30.56411 1.000 24.03589  ? 187 TRP A CE3 1 
ATOM   1380 C CZ2 . TRP A 1 187 ? -41.35879 23.46558 -32.47507 1.000 28.22589  ? 187 TRP A CZ2 1 
ATOM   1381 C CZ3 . TRP A 1 187 ? -39.04334 23.41594 -31.78073 1.000 27.58589  ? 187 TRP A CZ3 1 
ATOM   1382 C CH2 . TRP A 1 187 ? -40.03281 23.72655 -32.71587 1.000 25.89589  ? 187 TRP A CH2 1 
ATOM   1383 N N   . TYR A 1 188 ? -40.61055 21.05083 -24.62295 1.000 17.21323  ? 188 TYR A N   1 
ATOM   1384 C CA  . TYR A 1 188 ? -39.84621 20.45855 -23.53059 1.000 19.29323  ? 188 TYR A CA  1 
ATOM   1385 C C   . TYR A 1 188 ? -40.69544 20.27069 -22.28352 1.000 19.01323  ? 188 TYR A C   1 
ATOM   1386 O O   . TYR A 1 188 ? -40.17638 19.79612 -21.26172 1.000 17.32323  ? 188 TYR A O   1 
ATOM   1387 C CB  . TYR A 1 188 ? -38.59581 21.32506 -23.23894 1.000 16.39323  ? 188 TYR A CB  1 
ATOM   1388 C CG  . TYR A 1 188 ? -37.75422 21.51887 -24.49959 1.000 16.91323  ? 188 TYR A CG  1 
ATOM   1389 C CD1 . TYR A 1 188 ? -36.77613 20.59870 -24.86264 1.000 17.64323  ? 188 TYR A CD1 1 
ATOM   1390 C CD2 . TYR A 1 188 ? -37.97436 22.59734 -25.35203 1.000 16.58323  ? 188 TYR A CD2 1 
ATOM   1391 C CE1 . TYR A 1 188 ? -36.03634 20.75791 -26.02937 1.000 17.96323  ? 188 TYR A CE1 1 
ATOM   1392 C CE2 . TYR A 1 188 ? -37.25302 22.75147 -26.52050 1.000 16.43323  ? 188 TYR A CE2 1 
ATOM   1393 C CZ  . TYR A 1 188 ? -36.29134 21.84453 -26.85678 1.000 19.27323  ? 188 TYR A CZ  1 
ATOM   1394 O OH  . TYR A 1 188 ? -35.56961 22.02124 -28.02623 1.000 19.14323  ? 188 TYR A OH  1 
ATOM   1395 N N   . ARG A 1 189 ? -42.00145 20.58006 -22.36606 1.000 15.72415  ? 189 ARG A N   1 
ATOM   1396 C CA  . ARG A 1 189 ? -42.91296 20.54597 -21.22793 1.000 20.08415  ? 189 ARG A CA  1 
ATOM   1397 C C   . ARG A 1 189 ? -43.49130 19.15501 -20.99192 1.000 17.81415  ? 189 ARG A C   1 
ATOM   1398 O O   . ARG A 1 189 ? -43.92977 18.48047 -21.93293 1.000 18.14415  ? 189 ARG A O   1 
ATOM   1399 C CB  . ARG A 1 189 ? -44.08667 21.50182 -21.45095 1.000 28.79415  ? 189 ARG A CB  1 
ATOM   1400 C CG  . ARG A 1 189 ? -43.76680 22.95666 -21.36637 1.000 38.64415  ? 189 ARG A CG  1 
ATOM   1401 C CD  . ARG A 1 189 ? -44.37599 23.50996 -20.11803 1.000 44.20415  ? 189 ARG A CD  1 
ATOM   1402 N NE  . ARG A 1 189 ? -44.93159 24.83657 -20.32669 1.000 48.18415  ? 189 ARG A NE  1 
ATOM   1403 C CZ  . ARG A 1 189 ? -44.71182 25.86149 -19.52162 1.000 57.73415  ? 189 ARG A CZ  1 
ATOM   1404 N NH1 . ARG A 1 189 ? -43.91218 25.75180 -18.47259 1.000 55.34415  ? 189 ARG A NH1 1 
ATOM   1405 N NH2 . ARG A 1 189 ? -45.32084 27.01986 -19.76499 1.000 72.05415  ? 189 ARG A NH2 1 
ATOM   1406 N N   . ALA A 1 190 ? -43.54381 18.76095 -19.72295 1.000 18.96694  ? 190 ALA A N   1 
ATOM   1407 C CA  . ALA A 1 190 ? -44.18587 17.50393 -19.35821 1.000 22.20694  ? 190 ALA A CA  1 
ATOM   1408 C C   . ALA A 1 190 ? -45.68094 17.57541 -19.67694 1.000 21.46694  ? 190 ALA A C   1 
ATOM   1409 O O   . ALA A 1 190 ? -46.30239 18.62512 -19.48881 1.000 19.01694  ? 190 ALA A O   1 
ATOM   1410 C CB  . ALA A 1 190 ? -43.97057 17.20670 -17.87079 1.000 21.74694  ? 190 ALA A CB  1 
ATOM   1411 N N   . PRO A 1 191 ? -46.27783 16.49272 -20.17526 1.000 20.65029  ? 191 PRO A N   1 
ATOM   1412 C CA  . PRO A 1 191 ? -47.69332 16.55370 -20.59842 1.000 25.57029  ? 191 PRO A CA  1 
ATOM   1413 C C   . PRO A 1 191 ? -48.66989 16.88551 -19.48707 1.000 27.65029  ? 191 PRO A C   1 
ATOM   1414 O O   . PRO A 1 191 ? -49.68341 17.55252 -19.75648 1.000 27.89029  ? 191 PRO A O   1 
ATOM   1415 C CB  . PRO A 1 191 ? -47.95401 15.15120 -21.16573 1.000 26.79029  ? 191 PRO A CB  1 
ATOM   1416 C CG  . PRO A 1 191 ? -46.79789 14.30612 -20.68847 1.000 25.99029  ? 191 PRO A CG  1 
ATOM   1417 C CD  . PRO A 1 191 ? -45.63829 15.22355 -20.54458 1.000 20.83029  ? 191 PRO A CD  1 
ATOM   1418 N N   . GLU A 1 192 ? -48.37939 16.48985 -18.23774 1.000 24.09423  ? 192 GLU A N   1 
ATOM   1419 C CA  . GLU A 1 192 ? -49.28922 16.80265 -17.14195 1.000 25.74423  ? 192 GLU A CA  1 
ATOM   1420 C C   . GLU A 1 192 ? -49.32918 18.29102 -16.81777 1.000 29.65423  ? 192 GLU A C   1 
ATOM   1421 O O   . GLU A 1 192 ? -50.29670 18.75613 -16.20626 1.000 28.90423  ? 192 GLU A O   1 
ATOM   1422 C CB  . GLU A 1 192 ? -48.91649 16.00977 -15.88742 1.000 30.39423  ? 192 GLU A CB  1 
ATOM   1423 C CG  . GLU A 1 192 ? -47.62391 16.43829 -15.20124 1.000 28.35423  ? 192 GLU A CG  1 
ATOM   1424 C CD  . GLU A 1 192 ? -46.41818 15.64178 -15.65865 1.000 27.32423  ? 192 GLU A CD  1 
ATOM   1425 O OE1 . GLU A 1 192 ? -46.49699 14.98668 -16.72313 1.000 23.72423  ? 192 GLU A OE1 1 
ATOM   1426 O OE2 . GLU A 1 192 ? -45.38172 15.67678 -14.95501 1.000 27.80423  ? 192 GLU A OE2 1 
ATOM   1427 N N   . ILE A 1 193 ? -48.31865 19.06229 -17.20386 1.000 23.78207  ? 193 ILE A N   1 
ATOM   1428 C CA  . ILE A 1 193 ? -48.42364 20.49956 -17.00637 1.000 30.73207  ? 193 ILE A CA  1 
ATOM   1429 C C   . ILE A 1 193 ? -48.77675 21.23258 -18.29449 1.000 22.59207  ? 193 ILE A C   1 
ATOM   1430 O O   . ILE A 1 193 ? -49.39732 22.30387 -18.22729 1.000 25.03207  ? 193 ILE A O   1 
ATOM   1431 C CB  . ILE A 1 193 ? -47.14462 21.05740 -16.34933 1.000 39.92207  ? 193 ILE A CB  1 
ATOM   1432 C CG1 . ILE A 1 193 ? -45.97809 21.13291 -17.31318 1.000 44.97207  ? 193 ILE A CG1 1 
ATOM   1433 C CG2 . ILE A 1 193 ? -46.73849 20.13460 -15.27425 1.000 48.20207  ? 193 ILE A CG2 1 
ATOM   1434 C CD1 . ILE A 1 193 ? -44.75585 21.74169 -16.65813 1.000 49.43207  ? 193 ILE A CD1 1 
ATOM   1435 N N   . MET A 1 194 ? -48.46119 20.65882 -19.45802 1.000 24.68020  ? 194 MET A N   1 
ATOM   1436 C CA  . MET A 1 194 ? -48.89399 21.24146 -20.72485 1.000 29.42020  ? 194 MET A CA  1 
ATOM   1437 C C   . MET A 1 194 ? -50.41613 21.33329 -20.81486 1.000 28.65020  ? 194 MET A C   1 
ATOM   1438 O O   . MET A 1 194 ? -50.95615 22.29876 -21.36607 1.000 24.81020  ? 194 MET A O   1 
ATOM   1439 C CB  . MET A 1 194 ? -48.34754 20.42038 -21.89091 1.000 30.76020  ? 194 MET A CB  1 
ATOM   1440 C CG  . MET A 1 194 ? -48.79828 20.95186 -23.23374 1.000 33.67020  ? 194 MET A CG  1 
ATOM   1441 S SD  . MET A 1 194 ? -48.17078 20.03237 -24.61441 1.000 35.01020  ? 194 MET A SD  1 
ATOM   1442 C CE  . MET A 1 194 ? -48.92938 18.42490 -24.35428 1.000 34.78020  ? 194 MET A CE  1 
ATOM   1443 N N   . LEU A 1 195 ? -51.12501 20.35263 -20.26159 1.000 25.49952  ? 195 LEU A N   1 
ATOM   1444 C CA  . LEU A 1 195 ? -52.58293 20.33510 -20.29751 1.000 28.37952  ? 195 LEU A CA  1 
ATOM   1445 C C   . LEU A 1 195 ? -53.19860 20.42245 -18.90954 1.000 28.24952  ? 195 LEU A C   1 
ATOM   1446 O O   . LEU A 1 195 ? -54.39424 20.13430 -18.75757 1.000 28.53952  ? 195 LEU A O   1 
ATOM   1447 C CB  . LEU A 1 195 ? -53.08636 19.08147 -21.02766 1.000 31.08952  ? 195 LEU A CB  1 
ATOM   1448 C CG  . LEU A 1 195 ? -52.75289 19.05309 -22.52817 1.000 33.81952  ? 195 LEU A CG  1 
ATOM   1449 C CD1 . LEU A 1 195 ? -52.73987 17.62868 -23.07116 1.000 34.89952  ? 195 LEU A CD1 1 
ATOM   1450 C CD2 . LEU A 1 195 ? -53.72400 19.92357 -23.32238 1.000 35.77952  ? 195 LEU A CD2 1 
ATOM   1451 N N   . ASN A 1 196 ? -52.40699 20.79189 -17.89754 1.000 27.90065  ? 196 ASN A N   1 
ATOM   1452 C CA  . ASN A 1 196 ? -52.89608 21.07632 -16.54862 1.000 30.02065  ? 196 ASN A CA  1 
ATOM   1453 C C   . ASN A 1 196 ? -53.63294 19.87793 -15.95276 1.000 28.45065  ? 196 ASN A C   1 
ATOM   1454 O O   . ASN A 1 196 ? -54.72862 20.01121 -15.41009 1.000 30.32065  ? 196 ASN A O   1 
ATOM   1455 C CB  . ASN A 1 196 ? -53.79025 22.32071 -16.55661 1.000 39.58065  ? 196 ASN A CB  1 
ATOM   1456 C CG  . ASN A 1 196 ? -53.61220 23.17244 -15.32924 1.000 48.28065  ? 196 ASN A CG  1 
ATOM   1457 O OD1 . ASN A 1 196 ? -52.71451 24.01608 -15.27197 1.000 66.56065  ? 196 ASN A OD1 1 
ATOM   1458 N ND2 . ASN A 1 196 ? -54.47491 22.97122 -14.33831 1.000 51.17065  ? 196 ASN A ND2 1 
ATOM   1459 N N   . TRP A 1 197 ? -53.03199 18.69040 -16.07813 1.000 24.85096  ? 197 TRP A N   1 
ATOM   1460 C CA  . TRP A 1 197 ? -53.70580 17.47351 -15.62018 1.000 27.61096  ? 197 TRP A CA  1 
ATOM   1461 C C   . TRP A 1 197 ? -53.75508 17.36979 -14.10061 1.000 27.70096  ? 197 TRP A C   1 
ATOM   1462 O O   . TRP A 1 197 ? -54.69213 16.78239 -13.54997 1.000 30.04096  ? 197 TRP A O   1 
ATOM   1463 C CB  . TRP A 1 197 ? -53.00686 16.23732 -16.17418 1.000 25.65096  ? 197 TRP A CB  1 
ATOM   1464 C CG  . TRP A 1 197 ? -53.32324 15.95140 -17.59131 1.000 26.61096  ? 197 TRP A CG  1 
ATOM   1465 C CD1 . TRP A 1 197 ? -54.25786 16.56832 -18.36298 1.000 30.06096  ? 197 TRP A CD1 1 
ATOM   1466 C CD2 . TRP A 1 197 ? -52.69771 14.96669 -18.42077 1.000 28.31096  ? 197 TRP A CD2 1 
ATOM   1467 N NE1 . TRP A 1 197 ? -54.25575 16.02619 -19.63252 1.000 32.58096  ? 197 TRP A NE1 1 
ATOM   1468 C CE2 . TRP A 1 197 ? -53.30599 15.03963 -19.68895 1.000 32.72096  ? 197 TRP A CE2 1 
ATOM   1469 C CE3 . TRP A 1 197 ? -51.68026 14.03066 -18.21225 1.000 33.91096  ? 197 TRP A CE3 1 
ATOM   1470 C CZ2 . TRP A 1 197 ? -52.93099 14.21208 -20.74613 1.000 32.86096  ? 197 TRP A CZ2 1 
ATOM   1471 C CZ3 . TRP A 1 197 ? -51.31385 13.20505 -19.26038 1.000 34.77096  ? 197 TRP A CZ3 1 
ATOM   1472 C CH2 . TRP A 1 197 ? -51.93756 13.30165 -20.51079 1.000 34.95096  ? 197 TRP A CH2 1 
ATOM   1473 N N   . MET A 1 198 ? -52.75552 17.90538 -13.41360 1.000 32.56683  ? 198 MET A N   1 
ATOM   1474 C CA  . MET A 1 198 ? -52.58448 17.65026 -11.99233 1.000 34.96683  ? 198 MET A CA  1 
ATOM   1475 C C   . MET A 1 198 ? -51.54583 18.61808 -11.45768 1.000 35.79683  ? 198 MET A C   1 
ATOM   1476 O O   . MET A 1 198 ? -50.91326 19.36623 -12.20977 1.000 36.26683  ? 198 MET A O   1 
ATOM   1477 C CB  . MET A 1 198 ? -52.14888 16.20984 -11.72567 1.000 35.33683  ? 198 MET A CB  1 
ATOM   1478 C CG  . MET A 1 198 ? -50.75828 15.90119 -12.23091 1.000 37.69683  ? 198 MET A CG  1 
ATOM   1479 S SD  . MET A 1 198 ? -50.38876 14.15229 -12.02913 1.000 46.95683  ? 198 MET A SD  1 
ATOM   1480 C CE  . MET A 1 198 ? -51.39542 13.46204 -13.33533 1.000 45.17683  ? 198 MET A CE  1 
ATOM   1481 N N   . HIS A 1 199 ? -51.37270 18.58389 -10.14107 1.000 38.43693  ? 199 HIS A N   1 
ATOM   1482 C CA  . HIS A 1 199 ? -50.36142 19.41189 -9.50248  1.000 46.40693  ? 199 HIS A CA  1 
ATOM   1483 C C   . HIS A 1 199 ? -48.96251 18.92535 -9.87377  1.000 41.28693  ? 199 HIS A C   1 
ATOM   1484 O O   . HIS A 1 199 ? -48.70244 17.71981 -9.94599  1.000 47.61693  ? 199 HIS A O   1 
ATOM   1485 C CB  . HIS A 1 199 ? -50.56726 19.40681 -7.98794  1.000 50.67693  ? 199 HIS A CB  1 
ATOM   1486 C CG  . HIS A 1 199 ? -51.89902 19.95147 -7.56460  1.000 63.81693  ? 199 HIS A CG  1 
ATOM   1487 N ND1 . HIS A 1 199 ? -52.16803 21.30316 -7.50987  1.000 74.11693  ? 199 HIS A ND1 1 
ATOM   1488 C CD2 . HIS A 1 199 ? -53.04147 19.32677 -7.19094  1.000 76.21693  ? 199 HIS A CD2 1 
ATOM   1489 C CE1 . HIS A 1 199 ? -53.41404 21.48764 -7.11117  1.000 75.21693  ? 199 HIS A CE1 1 
ATOM   1490 N NE2 . HIS A 1 199 ? -53.96633 20.30454 -6.91131  1.000 80.40693  ? 199 HIS A NE2 1 
ATOM   1491 N N   . TYR A 1 200 ? -48.06551 19.88132 -10.11363 1.000 38.15569  ? 200 TYR A N   1 
ATOM   1492 C CA  . TYR A 1 200 ? -46.74423 19.58635 -10.65890 1.000 44.76569  ? 200 TYR A CA  1 
ATOM   1493 C C   . TYR A 1 200 ? -45.89039 18.83488 -9.64499  1.000 40.47569  ? 200 TYR A C   1 
ATOM   1494 O O   . TYR A 1 200 ? -45.85893 19.17948 -8.46352  1.000 34.55569  ? 200 TYR A O   1 
ATOM   1495 C CB  . TYR A 1 200 ? -45.97449 20.86124 -11.03760 1.000 44.30569  ? 200 TYR A CB  1 
ATOM   1496 C CG  . TYR A 1 200 ? -46.65414 21.96673 -11.82237 1.000 56.59569  ? 200 TYR A CG  1 
ATOM   1497 C CD1 . TYR A 1 200 ? -47.86598 21.78048 -12.48565 1.000 65.82569  ? 200 TYR A CD1 1 
ATOM   1498 C CD2 . TYR A 1 200 ? -46.04891 23.21492 -11.91069 1.000 61.20569  ? 200 TYR A CD2 1 
ATOM   1499 C CE1 . TYR A 1 200 ? -48.45167 22.80175 -13.20607 1.000 82.32569  ? 200 TYR A CE1 1 
ATOM   1500 C CE2 . TYR A 1 200 ? -46.62712 24.24266 -12.62355 1.000 72.80569  ? 200 TYR A CE2 1 
ATOM   1501 C CZ  . TYR A 1 200 ? -47.82730 24.03290 -13.27042 1.000 90.45569  ? 200 TYR A CZ  1 
ATOM   1502 O OH  . TYR A 1 200 ? -48.40684 25.06008 -13.98278 1.000 115.28569 ? 200 TYR A OH  1 
ATOM   1503 N N   . ASN A 1 201 ? -45.17919 17.82392 -10.12893 1.000 39.58635  ? 201 ASN A N   1 
ATOM   1504 C CA  . ASN A 1 201 ? -44.07194 17.16742 -9.45164  1.000 31.30635  ? 201 ASN A CA  1 
ATOM   1505 C C   . ASN A 1 201 ? -42.76712 17.86338 -9.84371  1.000 25.34635  ? 201 ASN A C   1 
ATOM   1506 O O   . ASN A 1 201 ? -42.67422 18.47742 -10.90361 1.000 24.06635  ? 201 ASN A O   1 
ATOM   1507 C CB  . ASN A 1 201 ? -44.04681 15.69393 -9.86600  1.000 38.93635  ? 201 ASN A CB  1 
ATOM   1508 C CG  . ASN A 1 201 ? -43.20277 14.83401 -8.97348  1.000 42.12635  ? 201 ASN A CG  1 
ATOM   1509 O OD1 . ASN A 1 201 ? -42.00697 15.06099 -8.81065  1.000 41.38635  ? 201 ASN A OD1 1 
ATOM   1510 N ND2 . ASN A 1 201 ? -43.82299 13.80811 -8.40139  1.000 47.22635  ? 201 ASN A ND2 1 
ATOM   1511 N N   . GLN A 1 202 ? -41.74659 17.75517 -8.97841  1.000 24.32105  ? 202 GLN A N   1 
ATOM   1512 C CA  . GLN A 1 202 ? -40.39589 18.18630 -9.35619  1.000 22.92105  ? 202 GLN A CA  1 
ATOM   1513 C C   . GLN A 1 202 ? -39.90747 17.48025 -10.61877 1.000 19.39105  ? 202 GLN A C   1 
ATOM   1514 O O   . GLN A 1 202 ? -39.06807 18.01932 -11.34634 1.000 14.94105  ? 202 GLN A O   1 
ATOM   1515 C CB  . GLN A 1 202 ? -39.40458 17.91055 -8.22377  1.000 22.76105  ? 202 GLN A CB  1 
ATOM   1516 C CG  . GLN A 1 202 ? -39.49442 18.84019 -7.04505  1.000 28.40105  ? 202 GLN A CG  1 
ATOM   1517 C CD  . GLN A 1 202 ? -38.77609 18.30465 -5.81851  1.000 30.09105  ? 202 GLN A CD  1 
ATOM   1518 O OE1 . GLN A 1 202 ? -38.18863 17.21733 -5.83748  1.000 29.87105  ? 202 GLN A OE1 1 
ATOM   1519 N NE2 . GLN A 1 202 ? -38.82004 19.07178 -4.74148  1.000 41.80105  ? 202 GLN A NE2 1 
ATOM   1520 N N   . THR A 1 203 ? -40.40526 16.26858 -10.89594 1.000 19.32606  ? 203 THR A N   1 
ATOM   1521 C CA  . THR A 1 203 ? -39.95653 15.55896 -12.08445 1.000 18.65606  ? 203 THR A CA  1 
ATOM   1522 C C   . THR A 1 203 ? -40.56246 16.09576 -13.37869 1.000 14.74606  ? 203 THR A C   1 
ATOM   1523 O O   . THR A 1 203 ? -40.32750 15.48256 -14.42680 1.000 14.19606  ? 203 THR A O   1 
ATOM   1524 C CB  . THR A 1 203 ? -40.25387 14.05770 -11.98123 1.000 22.03606  ? 203 THR A CB  1 
ATOM   1525 O OG1 . THR A 1 203 ? -41.66276 13.85808 -11.87462 1.000 26.56606  ? 203 THR A OG1 1 
ATOM   1526 C CG2 . THR A 1 203 ? -39.54146 13.43293 -10.76587 1.000 25.38606  ? 203 THR A CG2 1 
ATOM   1527 N N   . VAL A 1 204 ? -41.31486 17.20699 -13.36437 1.000 14.88016  ? 204 VAL A N   1 
ATOM   1528 C CA  . VAL A 1 204 ? -41.56666 17.87450 -14.64526 1.000 17.30016  ? 204 VAL A CA  1 
ATOM   1529 C C   . VAL A 1 204 ? -40.25716 18.36742 -15.24787 1.000 14.26016  ? 204 VAL A C   1 
ATOM   1530 O O   . VAL A 1 204 ? -40.09547 18.36417 -16.47381 1.000 15.93016  ? 204 VAL A O   1 
ATOM   1531 C CB  . VAL A 1 204 ? -42.60113 19.02082 -14.52365 1.000 18.27016  ? 204 VAL A CB  1 
ATOM   1532 C CG1 . VAL A 1 204 ? -43.88432 18.51174 -13.93644 1.000 20.77016  ? 204 VAL A CG1 1 
ATOM   1533 C CG2 . VAL A 1 204 ? -42.07132 20.20021 -13.72505 1.000 20.07016  ? 204 VAL A CG2 1 
ATOM   1534 N N   . ASP A 1 205 ? -39.29115 18.76077 -14.40396 1.000 14.61554  ? 205 ASP A N   1 
ATOM   1535 C CA  . ASP A 1 205 ? -37.98055 19.16998 -14.90168 1.000 13.42554  ? 205 ASP A CA  1 
ATOM   1536 C C   . ASP A 1 205 ? -37.20419 17.98486 -15.46075 1.000 12.42554  ? 205 ASP A C   1 
ATOM   1537 O O   . ASP A 1 205 ? -36.36295 18.16309 -16.34472 1.000 12.63554  ? 205 ASP A O   1 
ATOM   1538 C CB  . ASP A 1 205 ? -37.16190 19.84936 -13.79030 1.000 12.65554  ? 205 ASP A CB  1 
ATOM   1539 C CG  . ASP A 1 205 ? -37.74088 21.19909 -13.35922 1.000 15.61554  ? 205 ASP A CG  1 
ATOM   1540 O OD1 . ASP A 1 205 ? -38.36887 21.89966 -14.19511 1.000 18.08554  ? 205 ASP A OD1 1 
ATOM   1541 O OD2 . ASP A 1 205 ? -37.56172 21.56744 -12.17698 1.000 16.22554  ? 205 ASP A OD2 1 
ATOM   1542 N N   . ILE A 1 206 ? -37.44176 16.77841 -14.93244 1.000 13.80501  ? 206 ILE A N   1 
ATOM   1543 C CA  . ILE A 1 206 ? -36.74817 15.59568 -15.44393 1.000 11.64501  ? 206 ILE A CA  1 
ATOM   1544 C C   . ILE A 1 206 ? -37.25299 15.24419 -16.84252 1.000 10.49501  ? 206 ILE A C   1 
ATOM   1545 O O   . ILE A 1 206 ? -36.46994 14.84149 -17.72046 1.000 10.27501  ? 206 ILE A O   1 
ATOM   1546 C CB  . ILE A 1 206 ? -36.92145 14.42539 -14.45888 1.000 12.95501  ? 206 ILE A CB  1 
ATOM   1547 C CG1 . ILE A 1 206 ? -36.19738 14.72163 -13.14401 1.000 13.97501  ? 206 ILE A CG1 1 
ATOM   1548 C CG2 . ILE A 1 206 ? -36.39152 13.10291 -15.05940 1.000 13.99501  ? 206 ILE A CG2 1 
ATOM   1549 C CD1 . ILE A 1 206 ? -34.69850 14.90492 -13.31137 1.000 13.65501  ? 206 ILE A CD1 1 
ATOM   1550 N N   . TRP A 1 207 ? -38.56272 15.39681 -17.07793 1.000 10.94279  ? 207 TRP A N   1 
ATOM   1551 C CA  . TRP A 1 207 ? -39.09928 15.24568 -18.43418 1.000 11.71279  ? 207 TRP A CA  1 
ATOM   1552 C C   . TRP A 1 207 ? -38.37604 16.16478 -19.41774 1.000 10.75279  ? 207 TRP A C   1 
ATOM   1553 O O   . TRP A 1 207 ? -37.95747 15.73580 -20.50024 1.000 10.69279  ? 207 TRP A O   1 
ATOM   1554 C CB  . TRP A 1 207 ? -40.59765 15.54544 -18.43807 1.000 13.09279  ? 207 TRP A CB  1 
ATOM   1555 C CG  . TRP A 1 207 ? -41.21450 15.37815 -19.81085 1.000 14.45279  ? 207 TRP A CG  1 
ATOM   1556 C CD1 . TRP A 1 207 ? -41.26949 16.31140 -20.81943 1.000 14.98279  ? 207 TRP A CD1 1 
ATOM   1557 C CD2 . TRP A 1 207 ? -41.82513 14.19033 -20.33324 1.000 15.06279  ? 207 TRP A CD2 1 
ATOM   1558 N NE1 . TRP A 1 207 ? -41.89453 15.77689 -21.92347 1.000 15.49279  ? 207 TRP A NE1 1 
ATOM   1559 C CE2 . TRP A 1 207 ? -42.24954 14.48077 -21.64926 1.000 17.61279  ? 207 TRP A CE2 1 
ATOM   1560 C CE3 . TRP A 1 207 ? -42.08190 12.91609 -19.80299 1.000 17.81279  ? 207 TRP A CE3 1 
ATOM   1561 C CZ2 . TRP A 1 207 ? -42.89407 13.53864 -22.45032 1.000 17.30279  ? 207 TRP A CZ2 1 
ATOM   1562 C CZ3 . TRP A 1 207 ? -42.71889 11.97793 -20.60162 1.000 17.19279  ? 207 TRP A CZ3 1 
ATOM   1563 C CH2 . TRP A 1 207 ? -43.12273 12.29714 -21.90875 1.000 19.95279  ? 207 TRP A CH2 1 
ATOM   1564 N N   . SER A 1 208 ? -38.18794 17.43211 -19.03082 1.000 11.48285  ? 208 SER A N   1 
ATOM   1565 C CA  . SER A 1 208 ? -37.50369 18.38486 -19.90496 1.000 11.07285  ? 208 SER A CA  1 
ATOM   1566 C C   . SER A 1 208 ? -36.06955 17.96110 -20.18439 1.000 9.96285   ? 208 SER A C   1 
ATOM   1567 O O   . SER A 1 208 ? -35.60709 18.03788 -21.32938 1.000 13.07285  ? 208 SER A O   1 
ATOM   1568 C CB  . SER A 1 208 ? -37.54150 19.77458 -19.28172 1.000 10.34285  ? 208 SER A CB  1 
ATOM   1569 O OG  . SER A 1 208 ? -38.85239 20.16098 -18.92711 1.000 12.46285  ? 208 SER A OG  1 
ATOM   1570 N N   . VAL A 1 209 ? -35.35302 17.47083 -19.15895 1.000 9.21193   ? 209 VAL A N   1 
ATOM   1571 C CA  . VAL A 1 209 ? -33.98270 16.99930 -19.37797 1.000 9.79193   ? 209 VAL A CA  1 
ATOM   1572 C C   . VAL A 1 209 ? -33.95613 15.85835 -20.38475 1.000 9.81193   ? 209 VAL A C   1 
ATOM   1573 O O   . VAL A 1 209 ? -33.07515 15.79904 -21.25113 1.000 9.61193   ? 209 VAL A O   1 
ATOM   1574 C CB  . VAL A 1 209 ? -33.33119 16.57060 -18.04683 1.000 11.34193  ? 209 VAL A CB  1 
ATOM   1575 C CG1 . VAL A 1 209 ? -31.95714 15.95074 -18.28644 1.000 12.21193  ? 209 VAL A CG1 1 
ATOM   1576 C CG2 . VAL A 1 209 ? -33.20878 17.77389 -17.11951 1.000 12.93193  ? 209 VAL A CG2 1 
ATOM   1577 N N   . GLY A 1 210 ? -34.91860 14.93651 -20.28368 1.000 12.31509  ? 210 GLY A N   1 
ATOM   1578 C CA  . GLY A 1 210 ? -34.99733 13.86128 -21.26001 1.000 11.88509  ? 210 GLY A CA  1 
ATOM   1579 C C   . GLY A 1 210 ? -35.19350 14.37950 -22.67421 1.000 10.76509  ? 210 GLY A C   1 
ATOM   1580 O O   . GLY A 1 210 ? -34.53495 13.91674 -23.60809 1.000 10.94509  ? 210 GLY A O   1 
ATOM   1581 N N   . CYS A 1 211 ? -36.05713 15.39094 -22.83611 1.000 10.27570  ? 211 CYS A N   1 
ATOM   1582 C CA  . CYS A 1 211 ? -36.27606 15.96901 -24.16492 1.000 12.66570  ? 211 CYS A CA  1 
ATOM   1583 C C   . CYS A 1 211 ? -35.01316 16.63115 -24.68700 1.000 11.34570  ? 211 CYS A C   1 
ATOM   1584 O O   . CYS A 1 211 ? -34.66511 16.47441 -25.86219 1.000 11.79570  ? 211 CYS A O   1 
ATOM   1585 C CB  . CYS A 1 211 ? -37.41295 16.98034 -24.12451 1.000 13.73570  ? 211 CYS A CB  1 
ATOM   1586 S SG  . CYS A 1 211 ? -39.02652 16.25735 -23.76604 1.000 16.78570  ? 211 CYS A SG  1 
ATOM   1587 N N   . ILE A 1 212 ? -34.29562 17.34301 -23.81031 1.000 12.34316  ? 212 ILE A N   1 
ATOM   1588 C CA  . ILE A 1 212 ? -33.05939 18.01775 -24.20046 1.000 11.30316  ? 212 ILE A CA  1 
ATOM   1589 C C   . ILE A 1 212 ? -31.98839 17.00270 -24.57607 1.000 10.58316  ? 212 ILE A C   1 
ATOM   1590 O O   . ILE A 1 212 ? -31.30647 17.14103 -25.59962 1.000 10.89316  ? 212 ILE A O   1 
ATOM   1591 C CB  . ILE A 1 212 ? -32.58983 18.93577 -23.05769 1.000 12.13316  ? 212 ILE A CB  1 
ATOM   1592 C CG1 . ILE A 1 212 ? -33.59356 20.07547 -22.85302 1.000 13.45316  ? 212 ILE A CG1 1 
ATOM   1593 C CG2 . ILE A 1 212 ? -31.19046 19.44908 -23.33011 1.000 13.93316  ? 212 ILE A CG2 1 
ATOM   1594 C CD1 . ILE A 1 212 ? -33.41142 20.78782 -21.54668 1.000 14.30316  ? 212 ILE A CD1 1 
ATOM   1595 N N   . MET A 1 213 ? -31.83735 15.95818 -23.75461 1.000 10.75362  ? 213 MET A N   1 
ATOM   1596 C CA  . MET A 1 213 ? -30.83131 14.93937 -24.01267 1.000 11.51362  ? 213 MET A CA  1 
ATOM   1597 C C   . MET A 1 213 ? -31.08322 14.21356 -25.33049 1.000 10.57362  ? 213 MET A C   1 
ATOM   1598 O O   . MET A 1 213 ? -30.14021 13.97028 -26.09650 1.000 11.87362  ? 213 MET A O   1 
ATOM   1599 C CB  . MET A 1 213 ? -30.81090 13.93999 -22.85262 1.000 12.56362  ? 213 MET A CB  1 
ATOM   1600 C CG  . MET A 1 213 ? -29.85616 12.81035 -23.06612 1.000 16.50362  ? 213 MET A CG  1 
ATOM   1601 S SD  . MET A 1 213 ? -29.66199 11.84725 -21.55162 1.000 17.05362  ? 213 MET A SD  1 
ATOM   1602 C CE  . MET A 1 213 ? -28.81205 10.46065 -22.22849 1.000 22.27362  ? 213 MET A CE  1 
ATOM   1603 N N   . ALA A 1 214 ? -32.34375 13.83243 -25.58838 1.000 11.74847  ? 214 ALA A N   1 
ATOM   1604 C CA  . ALA A 1 214 ? -32.69220 13.19120 -26.85652 1.000 13.93847  ? 214 ALA A CA  1 
ATOM   1605 C C   . ALA A 1 214 ? -32.27586 14.05842 -28.03880 1.000 14.68847  ? 214 ALA A C   1 
ATOM   1606 O O   . ALA A 1 214 ? -31.64814 13.57582 -28.98823 1.000 14.79847  ? 214 ALA A O   1 
ATOM   1607 C CB  . ALA A 1 214 ? -34.19862 12.91885 -26.90528 1.000 14.87847  ? 214 ALA A CB  1 
ATOM   1608 N N   . GLU A 1 215 ? -32.56718 15.35468 -27.95001 1.000 16.41269  ? 215 GLU A N   1 
ATOM   1609 C CA  . GLU A 1 215 ? -32.23432 16.31101 -28.99873 1.000 16.57269  ? 215 GLU A CA  1 
ATOM   1610 C C   . GLU A 1 215 ? -30.72558 16.45828 -29.17936 1.000 16.34269  ? 215 GLU A C   1 
ATOM   1611 O O   . GLU A 1 215 ? -30.23908 16.50689 -30.31472 1.000 18.42269  ? 215 GLU A O   1 
ATOM   1612 C CB  . GLU A 1 215 ? -32.88789 17.65500 -28.66286 1.000 19.45269  ? 215 GLU A CB  1 
ATOM   1613 C CG  . GLU A 1 215 ? -32.53383 18.79109 -29.59547 1.000 22.69269  ? 215 GLU A CG  1 
ATOM   1614 C CD  . GLU A 1 215 ? -33.45808 19.97804 -29.42835 1.000 26.96269  ? 215 GLU A CD  1 
ATOM   1615 O OE1 . GLU A 1 215 ? -34.48080 19.86636 -28.71072 1.000 27.59269  ? 215 GLU A OE1 1 
ATOM   1616 O OE2 . GLU A 1 215 ? -33.16800 21.02431 -30.03743 1.000 40.04269  ? 215 GLU A OE2 1 
ATOM   1617 N N   . LEU A 1 216 ? -29.95959 16.50597 -28.07921 1.000 16.97836  ? 216 LEU A N   1 
ATOM   1618 C CA  . LEU A 1 216 ? -28.50041 16.57119 -28.20935 1.000 15.11836  ? 216 LEU A CA  1 
ATOM   1619 C C   . LEU A 1 216 ? -27.90845 15.30370 -28.81666 1.000 17.18836  ? 216 LEU A C   1 
ATOM   1620 O O   . LEU A 1 216 ? -26.87435 15.37222 -29.48508 1.000 18.70836  ? 216 LEU A O   1 
ATOM   1621 C CB  . LEU A 1 216 ? -27.84224 16.81177 -26.85303 1.000 15.54836  ? 216 LEU A CB  1 
ATOM   1622 C CG  . LEU A 1 216 ? -28.18869 18.07916 -26.08737 1.000 15.25836  ? 216 LEU A CG  1 
ATOM   1623 C CD1 . LEU A 1 216 ? -27.35826 18.14439 -24.79516 1.000 16.04836  ? 216 LEU A CD1 1 
ATOM   1624 C CD2 . LEU A 1 216 ? -27.90679 19.25571 -26.99052 1.000 19.53836  ? 216 LEU A CD2 1 
ATOM   1625 N N   . LEU A 1 217 ? -28.51998 14.14175 -28.56716 1.000 17.76342  ? 217 LEU A N   1 
ATOM   1626 C CA  . LEU A 1 217 ? -27.99298 12.88259 -29.09242 1.000 16.82342  ? 217 LEU A CA  1 
ATOM   1627 C C   . LEU A 1 217 ? -28.26972 12.71723 -30.58477 1.000 20.14342  ? 217 LEU A C   1 
ATOM   1628 O O   . LEU A 1 217 ? -27.45611 12.12949 -31.30373 1.000 24.25342  ? 217 LEU A O   1 
ATOM   1629 C CB  . LEU A 1 217 ? -28.60243 11.70682 -28.33422 1.000 19.80342  ? 217 LEU A CB  1 
ATOM   1630 C CG  . LEU A 1 217 ? -28.14097 11.50234 -26.88650 1.000 21.66342  ? 217 LEU A CG  1 
ATOM   1631 C CD1 . LEU A 1 217 ? -28.97503 10.42403 -26.21270 1.000 22.56342  ? 217 LEU A CD1 1 
ATOM   1632 C CD2 . LEU A 1 217 ? -26.66242 11.19578 -26.84482 1.000 22.54342  ? 217 LEU A CD2 1 
ATOM   1633 N N   . THR A 1 218 ? -29.42723 13.17428 -31.05638 1.000 21.29338  ? 218 THR A N   1 
ATOM   1634 C CA  . THR A 1 218 ? -29.86524 12.89843 -32.42233 1.000 24.05338  ? 218 THR A CA  1 
ATOM   1635 C C   . THR A 1 218 ? -29.72742 14.08401 -33.36889 1.000 27.33338  ? 218 THR A C   1 
ATOM   1636 O O   . THR A 1 218 ? -29.60060 13.87485 -34.58125 1.000 27.17338  ? 218 THR A O   1 
ATOM   1637 C CB  . THR A 1 218 ? -31.32959 12.45058 -32.42691 1.000 20.14338  ? 218 THR A CB  1 
ATOM   1638 O OG1 . THR A 1 218 ? -32.15910 13.51739 -31.94205 1.000 22.54338  ? 218 THR A OG1 1 
ATOM   1639 C CG2 . THR A 1 218 ? -31.51560 11.24144 -31.53415 1.000 23.59338  ? 218 THR A CG2 1 
ATOM   1640 N N   . GLY A 1 219 ? -29.74857 15.31258 -32.85514 1.000 22.82720  ? 219 GLY A N   1 
ATOM   1641 C CA  . GLY A 1 219 ? -29.81931 16.49031 -33.69976 1.000 25.09720  ? 219 GLY A CA  1 
ATOM   1642 C C   . GLY A 1 219 ? -31.22151 16.86601 -34.11894 1.000 25.57720  ? 219 GLY A C   1 
ATOM   1643 O O   . GLY A 1 219 ? -31.38062 17.72695 -34.99383 1.000 23.88720  ? 219 GLY A O   1 
ATOM   1644 N N   . ARG A 1 220 ? -32.24397 16.24191 -33.52692 1.000 21.95531  ? 220 ARG A N   1 
ATOM   1645 C CA  . ARG A 1 220 ? -33.64215 16.47694 -33.86383 1.000 23.30531  ? 220 ARG A CA  1 
ATOM   1646 C C   . ARG A 1 220 ? -34.42804 16.75822 -32.58934 1.000 24.25531  ? 220 ARG A C   1 
ATOM   1647 O O   . ARG A 1 220 ? -34.22209 16.09239 -31.57214 1.000 19.62531  ? 220 ARG A O   1 
ATOM   1648 C CB  . ARG A 1 220 ? -34.25514 15.25294 -34.60747 1.000 26.89531  ? 220 ARG A CB  1 
ATOM   1649 C CG  . ARG A 1 220 ? -33.33105 14.58280 -35.64023 1.000 29.09531  ? 220 ARG A CG  1 
ATOM   1650 C CD  . ARG A 1 220 ? -33.99336 13.38032 -36.32038 1.000 33.73531  ? 220 ARG A CD  1 
ATOM   1651 N NE  . ARG A 1 220 ? -33.04319 12.29865 -36.52661 1.000 37.13531  ? 220 ARG A NE  1 
ATOM   1652 C CZ  . ARG A 1 220 ? -33.00103 11.17849 -35.80939 1.000 44.95531  ? 220 ARG A CZ  1 
ATOM   1653 N NH1 . ARG A 1 220 ? -33.90168 10.91497 -34.86798 1.000 31.14531  ? 220 ARG A NH1 1 
ATOM   1654 N NH2 . ARG A 1 220 ? -32.03018 10.29742 -36.04026 1.000 41.75531  ? 220 ARG A NH2 1 
ATOM   1655 N N   . THR A 1 221 ? -35.31691 17.74973 -32.63520 1.000 18.59155  ? 221 THR A N   1 
ATOM   1656 C CA  . THR A 1 221 ? -36.27605 17.92915 -31.55385 1.000 23.13155  ? 221 THR A CA  1 
ATOM   1657 C C   . THR A 1 221 ? -37.16065 16.68874 -31.40566 1.000 25.04155  ? 221 THR A C   1 
ATOM   1658 O O   . THR A 1 221 ? -37.62730 16.11539 -32.39614 1.000 17.59155  ? 221 THR A O   1 
ATOM   1659 C CB  . THR A 1 221 ? -37.13706 19.16046 -31.82337 1.000 23.31155  ? 221 THR A CB  1 
ATOM   1660 O OG1 . THR A 1 221 ? -36.27676 20.29214 -31.96908 1.000 31.84155  ? 221 THR A OG1 1 
ATOM   1661 C CG2 . THR A 1 221 ? -38.08717 19.41451 -30.67780 1.000 21.03155  ? 221 THR A CG2 1 
ATOM   1662 N N   . LEU A 1 222 ? -37.39295 16.27258 -30.15391 1.000 21.18457  ? 222 LEU A N   1 
ATOM   1663 C CA  . LEU A 1 222 ? -38.02031 14.97463 -29.92803 1.000 19.15457  ? 222 LEU A CA  1 
ATOM   1664 C C   . LEU A 1 222 ? -39.52966 15.02534 -30.14319 1.000 17.11457  ? 222 LEU A C   1 
ATOM   1665 O O   . LEU A 1 222 ? -40.08537 14.15799 -30.82349 1.000 16.08457  ? 222 LEU A O   1 
ATOM   1666 C CB  . LEU A 1 222 ? -37.68836 14.47108 -28.52089 1.000 17.58457  ? 222 LEU A CB  1 
ATOM   1667 C CG  . LEU A 1 222 ? -38.34646 13.15393 -28.10319 1.000 15.45457  ? 222 LEU A CG  1 
ATOM   1668 C CD1 . LEU A 1 222 ? -37.96751 12.01148 -29.01788 1.000 14.73457  ? 222 LEU A CD1 1 
ATOM   1669 C CD2 . LEU A 1 222 ? -37.94574 12.86347 -26.65711 1.000 19.52457  ? 222 LEU A CD2 1 
ATOM   1670 N N   . PHE A 1 223 ? -40.20851 16.03128 -29.58610 1.000 15.07357  ? 223 PHE A N   1 
ATOM   1671 C CA  . PHE A 1 223 ? -41.65904 16.18649 -29.70561 1.000 16.83357  ? 223 PHE A CA  1 
ATOM   1672 C C   . PHE A 1 223 ? -42.03018 17.55896 -30.26848 1.000 18.90357  ? 223 PHE A C   1 
ATOM   1673 O O   . PHE A 1 223 ? -42.66648 18.35883 -29.57309 1.000 21.62357  ? 223 PHE A O   1 
ATOM   1674 C CB  . PHE A 1 223 ? -42.35279 16.02031 -28.35611 1.000 15.58357  ? 223 PHE A CB  1 
ATOM   1675 C CG  . PHE A 1 223 ? -42.03234 14.73113 -27.63551 1.000 18.29357  ? 223 PHE A CG  1 
ATOM   1676 C CD1 . PHE A 1 223 ? -42.27524 13.49281 -28.23474 1.000 19.45357  ? 223 PHE A CD1 1 
ATOM   1677 C CD2 . PHE A 1 223 ? -41.53569 14.76007 -26.33410 1.000 17.42357  ? 223 PHE A CD2 1 
ATOM   1678 C CE1 . PHE A 1 223 ? -42.00229 12.30310 -27.54039 1.000 18.68357  ? 223 PHE A CE1 1 
ATOM   1679 C CE2 . PHE A 1 223 ? -41.26684 13.56965 -25.64506 1.000 18.02357  ? 223 PHE A CE2 1 
ATOM   1680 C CZ  . PHE A 1 223 ? -41.50080 12.35419 -26.25540 1.000 18.06357  ? 223 PHE A CZ  1 
ATOM   1681 N N   . PRO A 1 224 ? -41.73012 17.84014 -31.53925 1.000 19.68286  ? 224 PRO A N   1 
ATOM   1682 C CA  . PRO A 1 224 ? -42.00051 19.20006 -32.06840 1.000 24.04286  ? 224 PRO A CA  1 
ATOM   1683 C C   . PRO A 1 224 ? -43.42586 19.39709 -32.59379 1.000 25.59286  ? 224 PRO A C   1 
ATOM   1684 O O   . PRO A 1 224 ? -43.64430 19.72282 -33.76228 1.000 24.72286  ? 224 PRO A O   1 
ATOM   1685 C CB  . PRO A 1 224 ? -40.95468 19.32411 -33.17757 1.000 21.02286  ? 224 PRO A CB  1 
ATOM   1686 C CG  . PRO A 1 224 ? -40.81565 17.94287 -33.70070 1.000 21.13286  ? 224 PRO A CG  1 
ATOM   1687 C CD  . PRO A 1 224 ? -41.01614 17.00663 -32.52587 1.000 17.61286  ? 224 PRO A CD  1 
ATOM   1688 N N   . GLY A 1 225 ? -44.41176 19.24452 -31.71342 1.000 23.51632  ? 225 GLY A N   1 
ATOM   1689 C CA  . GLY A 1 225 ? -45.79227 19.41793 -32.12224 1.000 25.62632  ? 225 GLY A CA  1 
ATOM   1690 C C   . GLY A 1 225 ? -46.15691 20.88092 -32.33790 1.000 30.07632  ? 225 GLY A C   1 
ATOM   1691 O O   . GLY A 1 225 ? -45.52618 21.79711 -31.81038 1.000 28.38632  ? 225 GLY A O   1 
ATOM   1692 N N   . THR A 1 226 ? -47.19418 21.10597 -33.15097 1.000 27.39483  ? 226 THR A N   1 
ATOM   1693 C CA  . THR A 1 226 ? -47.59297 22.47143 -33.47958 1.000 29.85483  ? 226 THR A CA  1 
ATOM   1694 C C   . THR A 1 226 ? -48.55886 23.05972 -32.46303 1.000 28.92483  ? 226 THR A C   1 
ATOM   1695 O O   . THR A 1 226 ? -48.46093 24.24579 -32.14918 1.000 37.42483  ? 226 THR A O   1 
ATOM   1696 C CB  . THR A 1 226 ? -48.22156 22.53841 -34.87294 1.000 29.20483  ? 226 THR A CB  1 
ATOM   1697 O OG1 . THR A 1 226 ? -49.28792 21.58960 -34.96222 1.000 36.43483  ? 226 THR A OG1 1 
ATOM   1698 C CG2 . THR A 1 226 ? -47.18786 22.24802 -35.94111 1.000 32.68483  ? 226 THR A CG2 1 
ATOM   1699 N N   . ASP A 1 227 ? -49.50397 22.27609 -31.94859 1.000 30.72222  ? 227 ASP A N   1 
ATOM   1700 C CA  . ASP A 1 227 ? -50.32017 22.70640 -30.81875 1.000 26.58222  ? 227 ASP A CA  1 
ATOM   1701 C C   . ASP A 1 227 ? -50.28758 21.62201 -29.75133 1.000 20.16222  ? 227 ASP A C   1 
ATOM   1702 O O   . ASP A 1 227 ? -49.61490 20.59647 -29.90154 1.000 24.99222  ? 227 ASP A O   1 
ATOM   1703 C CB  . ASP A 1 227 ? -51.76158 23.04939 -31.23272 1.000 32.12222  ? 227 ASP A CB  1 
ATOM   1704 C CG  . ASP A 1 227 ? -52.48889 21.89349 -31.92863 1.000 38.80222  ? 227 ASP A CG  1 
ATOM   1705 O OD1 . ASP A 1 227 ? -52.57700 20.76920 -31.38058 1.000 36.48222  ? 227 ASP A OD1 1 
ATOM   1706 O OD2 . ASP A 1 227 ? -53.02188 22.12981 -33.03147 1.000 43.63222  ? 227 ASP A OD2 1 
ATOM   1707 N N   . HIS A 1 228 ? -51.05682 21.85657 -28.68457 1.000 22.81887  ? 228 HIS A N   1 
ATOM   1708 C CA  . HIS A 1 228 ? -51.03869 20.98388 -27.51610 1.000 23.10887  ? 228 HIS A CA  1 
ATOM   1709 C C   . HIS A 1 228 ? -51.48177 19.57199 -27.86239 1.000 23.88887  ? 228 HIS A C   1 
ATOM   1710 O O   . HIS A 1 228 ? -50.92596 18.59895 -27.34037 1.000 21.90887  ? 228 HIS A O   1 
ATOM   1711 C CB  . HIS A 1 228 ? -51.94463 21.54392 -26.42120 1.000 26.64887  ? 228 HIS A CB  1 
ATOM   1712 C CG  . HIS A 1 228 ? -51.55816 22.90686 -25.93887 1.000 28.98887  ? 228 HIS A CG  1 
ATOM   1713 N ND1 . HIS A 1 228 ? -51.62539 24.03079 -26.73593 1.000 30.29887  ? 228 HIS A ND1 1 
ATOM   1714 C CD2 . HIS A 1 228 ? -51.12991 23.32953 -24.72612 1.000 27.32887  ? 228 HIS A CD2 1 
ATOM   1715 C CE1 . HIS A 1 228 ? -51.23178 25.08242 -26.04029 1.000 33.25887  ? 228 HIS A CE1 1 
ATOM   1716 N NE2 . HIS A 1 228 ? -50.92910 24.68365 -24.81736 1.000 28.36887  ? 228 HIS A NE2 1 
ATOM   1717 N N   . ILE A 1 229 ? -52.48201 19.44354 -28.74078 1.000 22.27282  ? 229 ILE A N   1 
ATOM   1718 C CA  . ILE A 1 229 ? -53.01736 18.12988 -29.09264 1.000 21.32282  ? 229 ILE A CA  1 
ATOM   1719 C C   . ILE A 1 229 ? -52.03697 17.37339 -29.97899 1.000 19.22282  ? 229 ILE A C   1 
ATOM   1720 O O   . ILE A 1 229 ? -51.78293 16.17843 -29.77249 1.000 19.27282  ? 229 ILE A O   1 
ATOM   1721 C CB  . ILE A 1 229 ? -54.39641 18.28661 -29.76752 1.000 22.68282  ? 229 ILE A CB  1 
ATOM   1722 C CG1 . ILE A 1 229 ? -55.33563 19.06588 -28.84509 1.000 21.35282  ? 229 ILE A CG1 1 
ATOM   1723 C CG2 . ILE A 1 229 ? -54.98703 16.92137 -30.14123 1.000 25.95282  ? 229 ILE A CG2 1 
ATOM   1724 C CD1 . ILE A 1 229 ? -55.56502 18.40353 -27.51058 1.000 23.22282  ? 229 ILE A CD1 1 
ATOM   1725 N N   . ASP A 1 230 ? -51.48928 18.05658 -30.99175 1.000 17.66667  ? 230 ASP A N   1 
ATOM   1726 C CA  . ASP A 1 230 ? -50.46992 17.46886 -31.85508 1.000 21.75667  ? 230 ASP A CA  1 
ATOM   1727 C C   . ASP A 1 230 ? -49.28136 16.96731 -31.03713 1.000 19.52667  ? 230 ASP A C   1 
ATOM   1728 O O   . ASP A 1 230 ? -48.77951 15.86062 -31.26272 1.000 18.65667  ? 230 ASP A O   1 
ATOM   1729 C CB  . ASP A 1 230 ? -50.02210 18.51627 -32.87778 1.000 32.55667  ? 230 ASP A CB  1 
ATOM   1730 C CG  . ASP A 1 230 ? -49.06280 17.97109 -33.90487 1.000 46.73667  ? 230 ASP A CG  1 
ATOM   1731 O OD1 . ASP A 1 230 ? -49.15552 16.76760 -34.22454 1.000 61.45667  ? 230 ASP A OD1 1 
ATOM   1732 O OD2 . ASP A 1 230 ? -48.20494 18.74940 -34.39803 1.000 53.18667  ? 230 ASP A OD2 1 
ATOM   1733 N N   . GLN A 1 231 ? -48.84621 17.75909 -30.06178 1.000 19.99125  ? 231 GLN A N   1 
ATOM   1734 C CA  . GLN A 1 231 ? -47.70323 17.37069 -29.24423 1.000 20.95125  ? 231 GLN A CA  1 
ATOM   1735 C C   . GLN A 1 231 ? -48.04237 16.19874 -28.33714 1.000 18.78125  ? 231 GLN A C   1 
ATOM   1736 O O   . GLN A 1 231 ? -47.23670 15.27198 -28.19642 1.000 19.65125  ? 231 GLN A O   1 
ATOM   1737 C CB  . GLN A 1 231 ? -47.22183 18.54336 -28.40121 1.000 22.29125  ? 231 GLN A CB  1 
ATOM   1738 C CG  . GLN A 1 231 ? -45.91732 18.20884 -27.67708 1.000 25.91125  ? 231 GLN A CG  1 
ATOM   1739 C CD  . GLN A 1 231 ? -45.37803 19.35923 -26.89290 1.000 32.04125  ? 231 GLN A CD  1 
ATOM   1740 O OE1 . GLN A 1 231 ? -45.54162 20.51318 -27.28940 1.000 33.84125  ? 231 GLN A OE1 1 
ATOM   1741 N NE2 . GLN A 1 231 ? -44.73592 19.06539 -25.75577 1.000 34.81125  ? 231 GLN A NE2 1 
ATOM   1742 N N   . LEU A 1 232 ? -49.22651 16.23290 -27.71157 1.000 17.71163  ? 232 LEU A N   1 
ATOM   1743 C CA  . LEU A 1 232 ? -49.65223 15.13370 -26.85609 1.000 18.49163  ? 232 LEU A CA  1 
ATOM   1744 C C   . LEU A 1 232 ? -49.70953 13.82580 -27.62866 1.000 19.91163  ? 232 LEU A C   1 
ATOM   1745 O O   . LEU A 1 232 ? -49.27471 12.78381 -27.12064 1.000 19.87163  ? 232 LEU A O   1 
ATOM   1746 C CB  . LEU A 1 232 ? -51.00893 15.44156 -26.23862 1.000 19.69163  ? 232 LEU A CB  1 
ATOM   1747 C CG  . LEU A 1 232 ? -51.59135 14.31785 -25.38756 1.000 23.28163  ? 232 LEU A CG  1 
ATOM   1748 C CD1 . LEU A 1 232 ? -50.82227 14.18308 -24.10004 1.000 24.62163  ? 232 LEU A CD1 1 
ATOM   1749 C CD2 . LEU A 1 232 ? -53.06563 14.57231 -25.11252 1.000 25.54163  ? 232 LEU A CD2 1 
ATOM   1750 N N   . LYS A 1 233 ? -50.20924 13.86382 -28.87055 1.000 16.35588  ? 233 LYS A N   1 
ATOM   1751 C CA  . LYS A 1 233 ? -50.24962 12.64654 -29.67063 1.000 18.54588  ? 233 LYS A CA  1 
ATOM   1752 C C   . LYS A 1 233 ? -48.84736 12.13704 -29.98627 1.000 17.81588  ? 233 LYS A C   1 
ATOM   1753 O O   . LYS A 1 233 ? -48.61133 10.92382 -29.99148 1.000 15.68588  ? 233 LYS A O   1 
ATOM   1754 C CB  . LYS A 1 233 ? -51.04684 12.88053 -30.95098 1.000 20.99588  ? 233 LYS A CB  1 
ATOM   1755 C CG  . LYS A 1 233 ? -52.53513 13.07388 -30.70506 1.000 24.25588  ? 233 LYS A CG  1 
ATOM   1756 C CD  . LYS A 1 233 ? -53.23191 13.51938 -31.98774 1.000 26.74588  ? 233 LYS A CD  1 
ATOM   1757 C CE  . LYS A 1 233 ? -54.74721 13.58858 -31.83012 1.000 31.16588  ? 233 LYS A CE  1 
ATOM   1758 N NZ  . LYS A 1 233 ? -55.38766 13.94643 -33.14197 1.000 35.20588  ? 233 LYS A NZ  1 
ATOM   1759 N N   . LEU A 1 234 ? -47.89488 13.04243 -30.23085 1.000 16.23144  ? 234 LEU A N   1 
ATOM   1760 C CA  . LEU A 1 234 ? -46.52514 12.60278 -30.48810 1.000 17.48144  ? 234 LEU A CA  1 
ATOM   1761 C C   . LEU A 1 234 ? -45.91466 11.96013 -29.25074 1.000 16.69144  ? 234 LEU A C   1 
ATOM   1762 O O   . LEU A 1 234 ? -45.24385 10.92809 -29.35036 1.000 20.46144  ? 234 LEU A O   1 
ATOM   1763 C CB  . LEU A 1 234 ? -45.65723 13.78057 -30.93690 1.000 18.53144  ? 234 LEU A CB  1 
ATOM   1764 C CG  . LEU A 1 234 ? -45.87960 14.37971 -32.31624 1.000 21.87144  ? 234 LEU A CG  1 
ATOM   1765 C CD1 . LEU A 1 234 ? -44.92250 15.54871 -32.49181 1.000 25.66144  ? 234 LEU A CD1 1 
ATOM   1766 C CD2 . LEU A 1 234 ? -45.63577 13.32951 -33.36703 1.000 25.49144  ? 234 LEU A CD2 1 
ATOM   1767 N N   . ILE A 1 235 ? -46.14005 12.56476 -28.08640 1.000 16.33463  ? 235 ILE A N   1 
ATOM   1768 C CA  . ILE A 1 235 ? -45.65005 12.00913 -26.82652 1.000 19.55463  ? 235 ILE A CA  1 
ATOM   1769 C C   . ILE A 1 235 ? -46.24454 10.62930 -26.58104 1.000 20.48463  ? 235 ILE A C   1 
ATOM   1770 O O   . ILE A 1 235 ? -45.52255 9.66952  -26.28929 1.000 20.92463  ? 235 ILE A O   1 
ATOM   1771 C CB  . ILE A 1 235 ? -45.97672 12.96517 -25.66919 1.000 17.72463  ? 235 ILE A CB  1 
ATOM   1772 C CG1 . ILE A 1 235 ? -45.18540 14.27332 -25.80401 1.000 18.91463  ? 235 ILE A CG1 1 
ATOM   1773 C CG2 . ILE A 1 235 ? -45.72231 12.28595 -24.31615 1.000 19.86463  ? 235 ILE A CG2 1 
ATOM   1774 C CD1 . ILE A 1 235 ? -45.61552 15.31847 -24.78540 1.000 16.71463  ? 235 ILE A CD1 1 
ATOM   1775 N N   . LEU A 1 236 ? -47.57309 10.50584 -26.70389 1.000 20.94131  ? 236 LEU A N   1 
ATOM   1776 C CA  . LEU A 1 236 ? -48.22617 9.24172  -26.36332 1.000 20.92131  ? 236 LEU A CA  1 
ATOM   1777 C C   . LEU A 1 236 ? -47.84002 8.12404  -27.31544 1.000 21.29131  ? 236 LEU A C   1 
ATOM   1778 O O   . LEU A 1 236 ? -47.86082 6.95486  -26.92244 1.000 23.51131  ? 236 LEU A O   1 
ATOM   1779 C CB  . LEU A 1 236 ? -49.74373 9.41397  -26.33601 1.000 21.44131  ? 236 LEU A CB  1 
ATOM   1780 C CG  . LEU A 1 236 ? -50.28078 10.39980 -25.28493 1.000 23.18131  ? 236 LEU A CG  1 
ATOM   1781 C CD1 . LEU A 1 236 ? -51.79846 10.42069 -25.28303 1.000 24.44131  ? 236 LEU A CD1 1 
ATOM   1782 C CD2 . LEU A 1 236 ? -49.73178 10.12735 -23.87674 1.000 24.84131  ? 236 LEU A CD2 1 
ATOM   1783 N N   . ARG A 1 237 ? -47.43570 8.45639  -28.53840 1.000 18.52489  ? 237 ARG A N   1 
ATOM   1784 C CA  . ARG A 1 237 ? -47.01449 7.42912  -29.47405 1.000 23.15489  ? 237 ARG A CA  1 
ATOM   1785 C C   . ARG A 1 237 ? -45.70251 6.79548  -29.04488 1.000 24.66489  ? 237 ARG A C   1 
ATOM   1786 O O   . ARG A 1 237 ? -45.45709 5.61893  -29.33808 1.000 22.89489  ? 237 ARG A O   1 
ATOM   1787 C CB  . ARG A 1 237 ? -46.87582 8.02451  -30.86908 1.000 28.49489  ? 237 ARG A CB  1 
ATOM   1788 C CG  . ARG A 1 237 ? -47.00509 7.01131  -31.96291 1.000 40.23489  ? 237 ARG A CG  1 
ATOM   1789 C CD  . ARG A 1 237 ? -47.07675 7.72344  -33.28854 1.000 48.64489  ? 237 ARG A CD  1 
ATOM   1790 N NE  . ARG A 1 237 ? -45.83566 8.43860  -33.54238 1.000 51.40489  ? 237 ARG A NE  1 
ATOM   1791 C CZ  . ARG A 1 237 ? -45.72927 9.47615  -34.35714 1.000 45.75489  ? 237 ARG A CZ  1 
ATOM   1792 N NH1 . ARG A 1 237 ? -46.78577 9.96045  -34.99897 1.000 45.89489  ? 237 ARG A NH1 1 
ATOM   1793 N NH2 . ARG A 1 237 ? -44.53810 10.04956 -34.52094 1.000 36.27489  ? 237 ARG A NH2 1 
ATOM   1794 N N   . LEU A 1 238 ? -44.85996 7.54961  -28.33641 1.000 19.70173  ? 238 LEU A N   1 
ATOM   1795 C CA  . LEU A 1 238 ? -43.60163 7.00473  -27.85042 1.000 21.11173  ? 238 LEU A CA  1 
ATOM   1796 C C   . LEU A 1 238 ? -43.77338 6.32789  -26.50312 1.000 18.75173  ? 238 LEU A C   1 
ATOM   1797 O O   . LEU A 1 238 ? -43.26225 5.22714  -26.29091 1.000 19.76173  ? 238 LEU A O   1 
ATOM   1798 C CB  . LEU A 1 238 ? -42.54611 8.10915  -27.73168 1.000 20.96173  ? 238 LEU A CB  1 
ATOM   1799 C CG  . LEU A 1 238 ? -41.19542 7.57532  -27.27236 1.000 22.44173  ? 238 LEU A CG  1 
ATOM   1800 C CD1 . LEU A 1 238 ? -40.49988 6.79368  -28.39865 1.000 23.21173  ? 238 LEU A CD1 1 
ATOM   1801 C CD2 . LEU A 1 238 ? -40.33041 8.71661  -26.74133 1.000 27.52173  ? 238 LEU A CD2 1 
ATOM   1802 N N   . VAL A 1 239 ? -44.50619 6.96033  -25.59078 1.000 19.26613  ? 239 VAL A N   1 
ATOM   1803 C CA  . VAL A 1 239 ? -44.53485 6.49580  -24.21627 1.000 23.13613  ? 239 VAL A CA  1 
ATOM   1804 C C   . VAL A 1 239 ? -45.80501 5.73029  -23.88502 1.000 24.94613  ? 239 VAL A C   1 
ATOM   1805 O O   . VAL A 1 239 ? -45.90448 5.17724  -22.78452 1.000 27.23613  ? 239 VAL A O   1 
ATOM   1806 C CB  . VAL A 1 239 ? -44.32206 7.66913  -23.23451 1.000 22.50613  ? 239 VAL A CB  1 
ATOM   1807 C CG1 . VAL A 1 239 ? -43.06741 8.45378  -23.62022 1.000 24.07613  ? 239 VAL A CG1 1 
ATOM   1808 C CG2 . VAL A 1 239 ? -45.55970 8.58422  -23.14577 1.000 21.81613  ? 239 VAL A CG2 1 
ATOM   1809 N N   . GLY A 1 240 ? -46.76282 5.65169  -24.80290 1.000 25.53383  ? 240 GLY A N   1 
ATOM   1810 C CA  . GLY A 1 240 ? -47.97998 4.92296  -24.46681 1.000 25.86383  ? 240 GLY A CA  1 
ATOM   1811 C C   . GLY A 1 240 ? -49.03947 5.81062  -23.84809 1.000 25.49383  ? 240 GLY A C   1 
ATOM   1812 O O   . GLY A 1 240 ? -48.75467 6.82981  -23.22270 1.000 27.77383  ? 240 GLY A O   1 
ATOM   1813 N N   . THR A 1 241 ? -50.29666 5.42109  -24.04951 1.000 27.54900  ? 241 THR A N   1 
ATOM   1814 C CA  . THR A 1 241 ? -51.41224 6.14088  -23.44703 1.000 30.41900  ? 241 THR A CA  1 
ATOM   1815 C C   . THR A 1 241 ? -51.47310 5.85345  -21.94231 1.000 27.46900  ? 241 THR A C   1 
ATOM   1816 O O   . THR A 1 241 ? -50.97286 4.82478  -21.47824 1.000 24.68900  ? 241 THR A O   1 
ATOM   1817 C CB  . THR A 1 241 ? -52.73188 5.74389  -24.11844 1.000 32.84900  ? 241 THR A CB  1 
ATOM   1818 O OG1 . THR A 1 241 ? -52.76886 4.32547  -24.28326 1.000 30.85900  ? 241 THR A OG1 1 
ATOM   1819 C CG2 . THR A 1 241 ? -52.88338 6.41742  -25.49345 1.000 33.91900  ? 241 THR A CG2 1 
ATOM   1820 N N   . PRO A 1 242 ? -52.05757 6.76102  -21.15447 1.000 25.87833  ? 242 PRO A N   1 
ATOM   1821 C CA  . PRO A 1 242 ? -52.12665 6.54418  -19.69983 1.000 30.62833  ? 242 PRO A CA  1 
ATOM   1822 C C   . PRO A 1 242 ? -52.92027 5.30228  -19.31181 1.000 33.22833  ? 242 PRO A C   1 
ATOM   1823 O O   . PRO A 1 242 ? -54.00039 5.03238  -19.84455 1.000 31.95833  ? 242 PRO A O   1 
ATOM   1824 C CB  . PRO A 1 242 ? -52.82225 7.80901  -19.18854 1.000 30.01833  ? 242 PRO A CB  1 
ATOM   1825 C CG  . PRO A 1 242 ? -52.51634 8.84448  -20.19730 1.000 30.57833  ? 242 PRO A CG  1 
ATOM   1826 C CD  . PRO A 1 242 ? -52.43328 8.13995  -21.51878 1.000 27.08833  ? 242 PRO A CD  1 
ATOM   1827 N N   . GLY A 1 243 ? -52.36906 4.54936  -18.36034 1.000 33.44758  ? 243 GLY A N   1 
ATOM   1828 C CA  . GLY A 1 243 ? -53.07680 3.44571  -17.75287 1.000 32.54758  ? 243 GLY A CA  1 
ATOM   1829 C C   . GLY A 1 243 ? -53.95527 3.90930  -16.60605 1.000 34.50758  ? 243 GLY A C   1 
ATOM   1830 O O   . GLY A 1 243 ? -53.96519 5.08077  -16.22509 1.000 30.06758  ? 243 GLY A O   1 
ATOM   1831 N N   . ALA A 1 244 ? -54.68194 2.94443  -16.03357 1.000 33.21652  ? 244 ALA A N   1 
ATOM   1832 C CA  . ALA A 1 244 ? -55.68106 3.24535  -15.01340 1.000 33.32652  ? 244 ALA A CA  1 
ATOM   1833 C C   . ALA A 1 244 ? -55.07266 3.89119  -13.77304 1.000 37.22652  ? 244 ALA A C   1 
ATOM   1834 O O   . ALA A 1 244 ? -55.71096 4.74410  -13.14207 1.000 33.80652  ? 244 ALA A O   1 
ATOM   1835 C CB  . ALA A 1 244 ? -56.42449 1.96368  -14.63231 1.000 38.67652  ? 244 ALA A CB  1 
ATOM   1836 N N   . GLU A 1 245 ? -53.84069 3.51718  -13.41778 1.000 35.05626  ? 245 GLU A N   1 
ATOM   1837 C CA  . GLU A 1 245 ? -53.20926 4.09722  -12.23738 1.000 33.86626  ? 245 GLU A CA  1 
ATOM   1838 C C   . GLU A 1 245 ? -52.91782 5.58177  -12.43563 1.000 30.25626  ? 245 GLU A C   1 
ATOM   1839 O O   . GLU A 1 245 ? -53.09122 6.38133  -11.50582 1.000 27.40626  ? 245 GLU A O   1 
ATOM   1840 C CB  . GLU A 1 245 ? -51.92291 3.34148  -11.90075 1.000 41.63626  ? 245 GLU A CB  1 
ATOM   1841 C CG  . GLU A 1 245 ? -51.21931 3.86829  -10.66003 1.000 45.47626  ? 245 GLU A CG  1 
ATOM   1842 C CD  . GLU A 1 245 ? -49.88723 3.19442  -10.40293 1.000 53.03626  ? 245 GLU A CD  1 
ATOM   1843 O OE1 . GLU A 1 245 ? -49.02010 3.21993  -11.30338 1.000 59.87626  ? 245 GLU A OE1 1 
ATOM   1844 O OE2 . GLU A 1 245 ? -49.70858 2.64178  -9.29637  1.000 50.40626  ? 245 GLU A OE2 1 
ATOM   1845 N N   . LEU A 1 246 ? -52.47858 5.97002  -13.63997 1.000 27.53485  ? 246 LEU A N   1 
ATOM   1846 C CA  . LEU A 1 246 ? -52.22306 7.38397  -13.90692 1.000 30.90485  ? 246 LEU A CA  1 
ATOM   1847 C C   . LEU A 1 246 ? -53.52509 8.15924  -14.07347 1.000 27.62485  ? 246 LEU A C   1 
ATOM   1848 O O   . LEU A 1 246 ? -53.63918 9.29202  -13.59089 1.000 26.07485  ? 246 LEU A O   1 
ATOM   1849 C CB  . LEU A 1 246 ? -51.34502 7.53890  -15.14966 1.000 29.25485  ? 246 LEU A CB  1 
ATOM   1850 C CG  . LEU A 1 246 ? -51.09386 8.98091  -15.62316 1.000 33.98485  ? 246 LEU A CG  1 
ATOM   1851 C CD1 . LEU A 1 246 ? -50.48210 9.85391  -14.53109 1.000 34.54485  ? 246 LEU A CD1 1 
ATOM   1852 C CD2 . LEU A 1 246 ? -50.19937 8.97566  -16.83123 1.000 35.15485  ? 246 LEU A CD2 1 
ATOM   1853 N N   . LEU A 1 247 ? -54.51664 7.55342  -14.74266 1.000 26.27802  ? 247 LEU A N   1 
ATOM   1854 C CA  . LEU A 1 247 ? -55.81563 8.19409  -14.95081 1.000 29.42802  ? 247 LEU A CA  1 
ATOM   1855 C C   . LEU A 1 247 ? -56.46941 8.59860  -13.63831 1.000 30.16802  ? 247 LEU A C   1 
ATOM   1856 O O   . LEU A 1 247 ? -57.12348 9.64357  -13.56286 1.000 31.33802  ? 247 LEU A O   1 
ATOM   1857 C CB  . LEU A 1 247 ? -56.73451 7.25622  -15.72349 1.000 35.49802  ? 247 LEU A CB  1 
ATOM   1858 C CG  . LEU A 1 247 ? -56.73309 7.43078  -17.23474 1.000 42.24802  ? 247 LEU A CG  1 
ATOM   1859 C CD1 . LEU A 1 247 ? -57.46702 6.27620  -17.89577 1.000 44.50802  ? 247 LEU A CD1 1 
ATOM   1860 C CD2 . LEU A 1 247 ? -57.38364 8.76840  -17.58535 1.000 45.76802  ? 247 LEU A CD2 1 
ATOM   1861 N N   . LYS A 1 248 ? -56.27974 7.79773  -12.58753 1.000 28.15552  ? 248 LYS A N   1 
ATOM   1862 C CA  . LYS A 1 248 ? -56.84058 8.09771  -11.27479 1.000 32.29552  ? 248 LYS A CA  1 
ATOM   1863 C C   . LYS A 1 248 ? -56.23089 9.34685  -10.65436 1.000 33.09552  ? 248 LYS A C   1 
ATOM   1864 O O   . LYS A 1 248 ? -56.84641 9.94903  -9.76812  1.000 36.68552  ? 248 LYS A O   1 
ATOM   1865 C CB  . LYS A 1 248 ? -56.62989 6.90306  -10.34654 1.000 44.98552  ? 248 LYS A CB  1 
ATOM   1866 C CG  . LYS A 1 248 ? -57.79279 6.58661  -9.41659  1.000 54.01552  ? 248 LYS A CG  1 
ATOM   1867 C CD  . LYS A 1 248 ? -57.62577 5.18836  -8.81197  1.000 59.40552  ? 248 LYS A CD  1 
ATOM   1868 C CE  . LYS A 1 248 ? -58.71601 4.86341  -7.79602  1.000 63.90552  ? 248 LYS A CE  1 
ATOM   1869 N NZ  . LYS A 1 248 ? -58.64464 5.73054  -6.58381  1.000 70.28552  ? 248 LYS A NZ  1 
ATOM   1870 N N   . LYS A 1 249 ? -55.04361 9.75327  -11.09879 1.000 30.69224  ? 249 LYS A N   1 
ATOM   1871 C CA  . LYS A 1 249 ? -54.37517 10.92042 -10.54154 1.000 30.43224  ? 249 LYS A CA  1 
ATOM   1872 C C   . LYS A 1 249 ? -54.72553 12.20648 -11.27515 1.000 30.30224  ? 249 LYS A C   1 
ATOM   1873 O O   . LYS A 1 249 ? -54.38713 13.29341 -10.79848 1.000 30.61224  ? 249 LYS A O   1 
ATOM   1874 C CB  . LYS A 1 249 ? -52.85459 10.71375 -10.56248 1.000 35.81224  ? 249 LYS A CB  1 
ATOM   1875 C CG  . LYS A 1 249 ? -52.35560 9.49100  -9.79570  1.000 37.14224  ? 249 LYS A CG  1 
ATOM   1876 C CD  . LYS A 1 249 ? -50.85679 9.26634  -10.03997 1.000 39.50224  ? 249 LYS A CD  1 
ATOM   1877 C CE  . LYS A 1 249 ? -50.31507 8.09502  -9.22683  1.000 39.39224  ? 249 LYS A CE  1 
ATOM   1878 N NZ  . LYS A 1 249 ? -48.98754 7.61468  -9.73404  1.000 38.03224  ? 249 LYS A NZ  1 
ATOM   1879 N N   . ILE A 1 250 ? -55.39142 12.11771 -12.41610 1.000 33.71890  ? 250 ILE A N   1 
ATOM   1880 C CA  . ILE A 1 250 ? -55.77355 13.31065 -13.16045 1.000 33.02890  ? 250 ILE A CA  1 
ATOM   1881 C C   . ILE A 1 250 ? -57.07539 13.85036 -12.58609 1.000 32.09890  ? 250 ILE A C   1 
ATOM   1882 O O   . ILE A 1 250 ? -58.11334 13.18650 -12.64410 1.000 39.31890  ? 250 ILE A O   1 
ATOM   1883 C CB  . ILE A 1 250 ? -55.88975 12.99346 -14.65237 1.000 30.14890  ? 250 ILE A CB  1 
ATOM   1884 C CG1 . ILE A 1 250 ? -54.49174 12.61977 -15.14255 1.000 26.18890  ? 250 ILE A CG1 1 
ATOM   1885 C CG2 . ILE A 1 250 ? -56.49259 14.16764 -15.42100 1.000 31.40890  ? 250 ILE A CG2 1 
ATOM   1886 C CD1 . ILE A 1 250 ? -54.42897 11.99570 -16.47806 1.000 26.85890  ? 250 ILE A CD1 1 
ATOM   1887 N N   . SER A 1 251 ? -57.02080 15.05825 -12.02057 1.000 31.91594  ? 251 SER A N   1 
ATOM   1888 C CA  . SER A 1 251 ? -58.16296 15.58867 -11.28097 1.000 39.91594  ? 251 SER A CA  1 
ATOM   1889 C C   . SER A 1 251 ? -59.22958 16.19984 -12.18379 1.000 39.86594  ? 251 SER A C   1 
ATOM   1890 O O   . SER A 1 251 ? -60.40929 16.19402 -11.81875 1.000 44.00594  ? 251 SER A O   1 
ATOM   1891 C CB  . SER A 1 251 ? -57.69067 16.62558 -10.26326 1.000 43.29594  ? 251 SER A CB  1 
ATOM   1892 O OG  . SER A 1 251 ? -56.76076 17.51165 -10.85677 1.000 47.55594  ? 251 SER A OG  1 
ATOM   1893 N N   . SER A 1 252 ? -58.85713 16.74157 -13.34056 1.000 41.43533  ? 252 SER A N   1 
ATOM   1894 C CA  . SER A 1 252 ? -59.85658 17.30382 -14.24378 1.000 38.55533  ? 252 SER A CA  1 
ATOM   1895 C C   . SER A 1 252 ? -60.67874 16.17807 -14.85816 1.000 36.88533  ? 252 SER A C   1 
ATOM   1896 O O   . SER A 1 252 ? -60.12119 15.28076 -15.49798 1.000 34.84533  ? 252 SER A O   1 
ATOM   1897 C CB  . SER A 1 252 ? -59.18434 18.12948 -15.33831 1.000 43.29533  ? 252 SER A CB  1 
ATOM   1898 O OG  . SER A 1 252 ? -60.06986 18.31639 -16.43361 1.000 45.44533  ? 252 SER A OG  1 
ATOM   1899 N N   . GLU A 1 253 ? -62.00087 16.21645 -14.66213 1.000 35.52903  ? 253 GLU A N   1 
ATOM   1900 C CA  . GLU A 1 253 ? -62.84655 15.15367 -15.19819 1.000 36.94903  ? 253 GLU A CA  1 
ATOM   1901 C C   . GLU A 1 253 ? -62.83424 15.15286 -16.72360 1.000 34.09903  ? 253 GLU A C   1 
ATOM   1902 O O   . GLU A 1 253 ? -62.82762 14.08507 -17.34874 1.000 36.18903  ? 253 GLU A O   1 
ATOM   1903 C CB  . GLU A 1 253 ? -64.27512 15.29050 -14.67053 1.000 42.27903  ? 253 GLU A CB  1 
ATOM   1904 C CG  . GLU A 1 253 ? -65.19867 14.14343 -15.10895 1.000 45.03903  ? 253 GLU A CG  1 
ATOM   1905 C CD  . GLU A 1 253 ? -66.60891 14.24554 -14.53991 1.000 52.58903  ? 253 GLU A CD  1 
ATOM   1906 O OE1 . GLU A 1 253 ? -66.82754 15.04858 -13.60626 1.000 52.33903  ? 253 GLU A OE1 1 
ATOM   1907 O OE2 . GLU A 1 253 ? -67.50301 13.51778 -15.02906 1.000 56.01903  ? 253 GLU A OE2 1 
ATOM   1908 N N   . SER A 1 254 ? -62.80126 16.34093 -17.33815 1.000 35.49054  ? 254 SER A N   1 
ATOM   1909 C CA  . SER A 1 254 ? -62.77775 16.43127 -18.79753 1.000 31.90054  ? 254 SER A CA  1 
ATOM   1910 C C   . SER A 1 254 ? -61.48475 15.87063 -19.36707 1.000 29.11054  ? 254 SER A C   1 
ATOM   1911 O O   . SER A 1 254 ? -61.49690 15.20396 -20.40944 1.000 36.67054  ? 254 SER A O   1 
ATOM   1912 C CB  . SER A 1 254 ? -62.96327 17.88303 -19.24325 1.000 32.21054  ? 254 SER A CB  1 
ATOM   1913 O OG  . SER A 1 254 ? -62.90414 18.01106 -20.66603 1.000 28.24054  ? 254 SER A OG  1 
ATOM   1914 N N   . ALA A 1 255 ? -60.36151 16.14350 -18.70256 1.000 30.00361  ? 255 ALA A N   1 
ATOM   1915 C CA  . ALA A 1 255 ? -59.08386 15.58656 -19.13683 1.000 32.11361  ? 255 ALA A CA  1 
ATOM   1916 C C   . ALA A 1 255 ? -59.10522 14.06406 -19.09947 1.000 30.63361  ? 255 ALA A C   1 
ATOM   1917 O O   . ALA A 1 255 ? -58.64912 13.41059 -20.04599 1.000 31.71361  ? 255 ALA A O   1 
ATOM   1918 C CB  . ALA A 1 255 ? -57.95208 16.13164 -18.26576 1.000 37.85361  ? 255 ALA A CB  1 
ATOM   1919 N N   . ARG A 1 256 ? -59.66014 13.48543 -18.02724 1.000 31.39880  ? 256 ARG A N   1 
ATOM   1920 C CA  . ARG A 1 256 ? -59.79781 12.03114 -17.94265 1.000 35.32880  ? 256 ARG A CA  1 
ATOM   1921 C C   . ARG A 1 256 ? -60.68060 11.49468 -19.05997 1.000 32.34880  ? 256 ARG A C   1 
ATOM   1922 O O   . ARG A 1 256 ? -60.35262 10.48199 -19.69057 1.000 37.70880  ? 256 ARG A O   1 
ATOM   1923 C CB  . ARG A 1 256 ? -60.37627 11.62120 -16.58906 1.000 32.97880  ? 256 ARG A CB  1 
ATOM   1924 C CG  . ARG A 1 256 ? -59.42641 11.73987 -15.42941 1.000 35.27880  ? 256 ARG A CG  1 
ATOM   1925 C CD  . ARG A 1 256 ? -59.94514 10.94133 -14.23263 1.000 33.78880  ? 256 ARG A CD  1 
ATOM   1926 N NE  . ARG A 1 256 ? -61.31359 11.27327 -13.85076 1.000 33.35880  ? 256 ARG A NE  1 
ATOM   1927 C CZ  . ARG A 1 256 ? -61.64911 12.18936 -12.95252 1.000 34.34880  ? 256 ARG A CZ  1 
ATOM   1928 N NH1 . ARG A 1 256 ? -60.73761 12.94501 -12.36131 1.000 35.53880  ? 256 ARG A NH1 1 
ATOM   1929 N NH2 . ARG A 1 256 ? -62.93335 12.35037 -12.63797 1.000 40.47880  ? 256 ARG A NH2 1 
ATOM   1930 N N   . ASN A 1 257 ? -61.81245 12.16248 -19.31298 1.000 30.63333  ? 257 ASN A N   1 
ATOM   1931 C CA  . ASN A 1 257 ? -62.70179 11.72610 -20.38390 1.000 32.52333  ? 257 ASN A CA  1 
ATOM   1932 C C   . ASN A 1 257 ? -62.03170 11.84539 -21.74320 1.000 27.15333  ? 257 ASN A C   1 
ATOM   1933 O O   . ASN A 1 257 ? -62.26675 11.01543 -22.62273 1.000 30.24333  ? 257 ASN A O   1 
ATOM   1934 C CB  . ASN A 1 257 ? -64.00134 12.53061 -20.36174 1.000 36.80333  ? 257 ASN A CB  1 
ATOM   1935 C CG  . ASN A 1 257 ? -64.89716 12.15018 -19.20679 1.000 40.87333  ? 257 ASN A CG  1 
ATOM   1936 O OD1 . ASN A 1 257 ? -65.25639 12.98765 -18.38024 1.000 48.60333  ? 257 ASN A OD1 1 
ATOM   1937 N ND2 . ASN A 1 257 ? -65.26161 10.87899 -19.14080 1.000 45.30333  ? 257 ASN A ND2 1 
ATOM   1938 N N   . TYR A 1 258 ? -61.18451 12.86360 -21.93572 1.000 27.38213  ? 258 TYR A N   1 
ATOM   1939 C CA  . TYR A 1 258 ? -60.51123 13.00394 -23.22541 1.000 26.43213  ? 258 TYR A CA  1 
ATOM   1940 C C   . TYR A 1 258 ? -59.49944 11.88675 -23.43524 1.000 26.35213  ? 258 TYR A C   1 
ATOM   1941 O O   . TYR A 1 258 ? -59.46150 11.26335 -24.50523 1.000 26.30213  ? 258 TYR A O   1 
ATOM   1942 C CB  . TYR A 1 258 ? -59.82458 14.36995 -23.34745 1.000 25.08213  ? 258 TYR A CB  1 
ATOM   1943 C CG  . TYR A 1 258 ? -58.98202 14.44750 -24.60087 1.000 23.49213  ? 258 TYR A CG  1 
ATOM   1944 C CD1 . TYR A 1 258 ? -59.56060 14.26466 -25.85794 1.000 24.44213  ? 258 TYR A CD1 1 
ATOM   1945 C CD2 . TYR A 1 258 ? -57.60971 14.66759 -24.53777 1.000 25.30213  ? 258 TYR A CD2 1 
ATOM   1946 C CE1 . TYR A 1 258 ? -58.79875 14.31181 -27.02221 1.000 24.18213  ? 258 TYR A CE1 1 
ATOM   1947 C CE2 . TYR A 1 258 ? -56.83312 14.70915 -25.70263 1.000 23.47213  ? 258 TYR A CE2 1 
ATOM   1948 C CZ  . TYR A 1 258 ? -57.44131 14.53686 -26.93874 1.000 24.77213  ? 258 TYR A CZ  1 
ATOM   1949 O OH  . TYR A 1 258 ? -56.70499 14.57673 -28.09849 1.000 24.01213  ? 258 TYR A OH  1 
ATOM   1950 N N   . ILE A 1 259 ? -58.67687 11.61802 -22.41495 1.000 29.82927  ? 259 ILE A N   1 
ATOM   1951 C CA  . ILE A 1 259 ? -57.67447 10.55348 -22.49161 1.000 31.84927  ? 259 ILE A CA  1 
ATOM   1952 C C   . ILE A 1 259 ? -58.33113 9.20153  -22.74851 1.000 31.64927  ? 259 ILE A C   1 
ATOM   1953 O O   . ILE A 1 259 ? -57.84620 8.40292  -23.55933 1.000 29.66927  ? 259 ILE A O   1 
ATOM   1954 C CB  . ILE A 1 259 ? -56.83085 10.53727 -21.20315 1.000 35.50927  ? 259 ILE A CB  1 
ATOM   1955 C CG1 . ILE A 1 259 ? -55.90764 11.74650 -21.17803 1.000 35.62927  ? 259 ILE A CG1 1 
ATOM   1956 C CG2 . ILE A 1 259 ? -56.00895 9.26576  -21.10166 1.000 36.19927  ? 259 ILE A CG2 1 
ATOM   1957 C CD1 . ILE A 1 259 ? -55.65179 12.22442 -19.80686 1.000 36.51927  ? 259 ILE A CD1 1 
ATOM   1958 N N   . GLN A 1 260 ? -59.46573 8.93992  -22.09533 1.000 32.99668  ? 260 GLN A N   1 
ATOM   1959 C CA  . GLN A 1 260 ? -60.18375 7.68962  -22.32076 1.000 36.53668  ? 260 GLN A CA  1 
ATOM   1960 C C   . GLN A 1 260 ? -60.77262 7.59348  -23.72478 1.000 34.23668  ? 260 GLN A C   1 
ATOM   1961 O O   . GLN A 1 260 ? -61.03964 6.48264  -24.19595 1.000 38.02668  ? 260 GLN A O   1 
ATOM   1962 C CB  . GLN A 1 260 ? -61.28932 7.53074  -21.27690 1.000 45.43668  ? 260 GLN A CB  1 
ATOM   1963 C CG  . GLN A 1 260 ? -60.79080 7.27168  -19.85531 1.000 50.81668  ? 260 GLN A CG  1 
ATOM   1964 C CD  . GLN A 1 260 ? -61.92036 7.31823  -18.84822 1.000 58.32668  ? 260 GLN A CD  1 
ATOM   1965 O OE1 . GLN A 1 260 ? -62.34335 8.39657  -18.42371 1.000 64.18668  ? 260 GLN A OE1 1 
ATOM   1966 N NE2 . GLN A 1 260 ? -62.43454 6.14768  -18.47747 1.000 56.51668  ? 260 GLN A NE2 1 
ATOM   1967 N N   . SER A 1 261 ? -60.96549 8.72123  -24.41342 1.000 39.27939  ? 261 SER A N   1 
ATOM   1968 C CA  . SER A 1 261 ? -61.44789 8.69375  -25.78976 1.000 31.91939  ? 261 SER A CA  1 
ATOM   1969 C C   . SER A 1 261 ? -60.36405 8.31902  -26.79122 1.000 30.52939  ? 261 SER A C   1 
ATOM   1970 O O   . SER A 1 261 ? -60.68639 8.00045  -27.93780 1.000 32.44939  ? 261 SER A O   1 
ATOM   1971 C CB  . SER A 1 261 ? -62.04089 10.05439 -26.16749 1.000 30.87939  ? 261 SER A CB  1 
ATOM   1972 O OG  . SER A 1 261 ? -61.02808 11.01663 -26.41390 1.000 32.06939  ? 261 SER A OG  1 
ATOM   1973 N N   . LEU A 1 262 ? -59.09821 8.35197  -26.39246 1.000 27.86680  ? 262 LEU A N   1 
ATOM   1974 C CA  . LEU A 1 262 ? -58.00041 8.10826  -27.31152 1.000 32.23680  ? 262 LEU A CA  1 
ATOM   1975 C C   . LEU A 1 262 ? -57.84571 6.61846  -27.58310 1.000 37.07680  ? 262 LEU A C   1 
ATOM   1976 O O   . LEU A 1 262 ? -58.04313 5.79014  -26.68886 1.000 37.73680  ? 262 LEU A O   1 
ATOM   1977 C CB  . LEU A 1 262 ? -56.70446 8.67628  -26.73188 1.000 33.85680  ? 262 LEU A CB  1 
ATOM   1978 C CG  . LEU A 1 262 ? -56.65858 10.20352 -26.67828 1.000 40.35680  ? 262 LEU A CG  1 
ATOM   1979 C CD1 . LEU A 1 262 ? -55.37358 10.69385 -26.05381 1.000 43.02680  ? 262 LEU A CD1 1 
ATOM   1980 C CD2 . LEU A 1 262 ? -56.82958 10.78039 -28.08283 1.000 38.81680  ? 262 LEU A CD2 1 
ATOM   1981 N N   . ALA A 1 263 ? -57.49161 6.28287  -28.82479 1.000 42.74957  ? 263 ALA A N   1 
ATOM   1982 C CA  . ALA A 1 263 ? -57.11542 4.91081  -29.14532 1.000 57.73957  ? 263 ALA A CA  1 
ATOM   1983 C C   . ALA A 1 263 ? -55.89244 4.52590  -28.33178 1.000 45.47957  ? 263 ALA A C   1 
ATOM   1984 O O   . ALA A 1 263 ? -54.90289 5.26302  -28.29705 1.000 40.44957  ? 263 ALA A O   1 
ATOM   1985 C CB  . ALA A 1 263 ? -56.82275 4.75299  -30.63903 1.000 26.58957  ? 263 ALA A CB  1 
ATOM   1986 N N   . GLN A 1 264 ? -55.98635 3.39254  -27.64133 1.000 35.50085  ? 264 GLN A N   1 
ATOM   1987 C CA  . GLN A 1 264 ? -54.90253 2.95082  -26.78139 1.000 36.35085  ? 264 GLN A CA  1 
ATOM   1988 C C   . GLN A 1 264 ? -53.64446 2.69961  -27.59758 1.000 40.94085  ? 264 GLN A C   1 
ATOM   1989 O O   . GLN A 1 264 ? -53.70471 2.25209  -28.74508 1.000 41.48085  ? 264 GLN A O   1 
ATOM   1990 C CB  . GLN A 1 264 ? -55.30181 1.68805  -26.03144 1.000 41.11085  ? 264 GLN A CB  1 
ATOM   1991 C CG  . GLN A 1 264 ? -56.24492 1.93928  -24.87907 1.000 49.45085  ? 264 GLN A CG  1 
ATOM   1992 C CD  . GLN A 1 264 ? -56.18693 0.83091  -23.84878 1.000 56.58085  ? 264 GLN A CD  1 
ATOM   1993 O OE1 . GLN A 1 264 ? -57.21445 0.26900  -23.46453 1.000 71.17085  ? 264 GLN A OE1 1 
ATOM   1994 N NE2 . GLN A 1 264 ? -54.97679 0.50958  -23.39253 1.000 56.61085  ? 264 GLN A NE2 1 
ATOM   1995 N N   . MET A 1 265 ? -52.50265 3.04826  -27.01838 1.000 38.43218  ? 265 MET A N   1 
ATOM   1996 C CA  . MET A 1 265 ? -51.24087 2.84966  -27.70115 1.000 37.42218  ? 265 MET A CA  1 
ATOM   1997 C C   . MET A 1 265 ? -50.22990 2.26407  -26.72708 1.000 27.51218  ? 265 MET A C   1 
ATOM   1998 O O   . MET A 1 265 ? -50.14342 2.70399  -25.57131 1.000 22.75218  ? 265 MET A O   1 
ATOM   1999 C CB  . MET A 1 265 ? -50.70998 4.16385  -28.28980 1.000 41.29218  ? 265 MET A CB  1 
ATOM   2000 C CG  . MET A 1 265 ? -51.44428 4.59742  -29.54497 1.000 51.39218  ? 265 MET A CG  1 
ATOM   2001 S SD  . MET A 1 265 ? -50.79367 6.10808  -30.26692 1.000 51.71218  ? 265 MET A SD  1 
ATOM   2002 C CE  . MET A 1 265 ? -51.40412 7.33182  -29.10811 1.000 35.99218  ? 265 MET A CE  1 
ATOM   2003 N N   . PRO A 1 266 ? -49.47857 1.25517  -27.14859 1.000 33.05199  ? 266 PRO A N   1 
ATOM   2004 C CA  . PRO A 1 266 ? -48.44818 0.70131  -26.27369 1.000 33.52199  ? 266 PRO A CA  1 
ATOM   2005 C C   . PRO A 1 266 ? -47.24633 1.62966  -26.23660 1.000 30.14199  ? 266 PRO A C   1 
ATOM   2006 O O   . PRO A 1 266 ? -47.00788 2.40790  -27.16537 1.000 29.03199  ? 266 PRO A O   1 
ATOM   2007 C CB  . PRO A 1 266 ? -48.10258 -0.62841 -26.95087 1.000 31.37199  ? 266 PRO A CB  1 
ATOM   2008 C CG  . PRO A 1 266 ? -48.27117 -0.31944 -28.40804 1.000 33.44199  ? 266 PRO A CG  1 
ATOM   2009 C CD  . PRO A 1 266 ? -49.43608 0.65646  -28.49775 1.000 36.48199  ? 266 PRO A CD  1 
ATOM   2010 N N   . LYS A 1 267 ? -46.49702 1.54685  -25.13560 1.000 27.38223  ? 267 LYS A N   1 
ATOM   2011 C CA  . LYS A 1 267 ? -45.18811 2.18532  -25.07901 1.000 32.29223  ? 267 LYS A CA  1 
ATOM   2012 C C   . LYS A 1 267 ? -44.29137 1.59299  -26.15786 1.000 30.90223  ? 267 LYS A C   1 
ATOM   2013 O O   . LYS A 1 267 ? -44.39859 0.41056  -26.48974 1.000 33.40223  ? 267 LYS A O   1 
ATOM   2014 C CB  . LYS A 1 267 ? -44.55726 1.98909  -23.69838 1.000 36.48223  ? 267 LYS A CB  1 
ATOM   2015 C CG  . LYS A 1 267 ? -43.30771 2.81684  -23.46559 1.000 39.16223  ? 267 LYS A CG  1 
ATOM   2016 C CD  . LYS A 1 267 ? -42.55742 2.36532  -22.23479 1.000 40.37223  ? 267 LYS A CD  1 
ATOM   2017 C CE  . LYS A 1 267 ? -41.69101 1.16225  -22.53450 1.000 44.70223  ? 267 LYS A CE  1 
ATOM   2018 N NZ  . LYS A 1 267 ? -40.49253 1.54023  -23.33833 1.000 42.41223  ? 267 LYS A NZ  1 
ATOM   2019 N N   . MET A 1 268 ? -43.43410 2.42061  -26.74323 1.000 27.85269  ? 268 MET A N   1 
ATOM   2020 C CA  . MET A 1 268 ? -42.48554 1.89239  -27.70809 1.000 27.16269  ? 268 MET A CA  1 
ATOM   2021 C C   . MET A 1 268 ? -41.18676 1.48774  -27.02422 1.000 25.87269  ? 268 MET A C   1 
ATOM   2022 O O   . MET A 1 268 ? -40.84673 1.96289  -25.93683 1.000 22.75269  ? 268 MET A O   1 
ATOM   2023 C CB  . MET A 1 268 ? -42.17817 2.91061  -28.80364 1.000 30.16269  ? 268 MET A CB  1 
ATOM   2024 C CG  . MET A 1 268 ? -43.29454 3.10626  -29.79744 1.000 37.03269  ? 268 MET A CG  1 
ATOM   2025 S SD  . MET A 1 268 ? -42.88327 4.44214  -30.92911 1.000 48.91269  ? 268 MET A SD  1 
ATOM   2026 C CE  . MET A 1 268 ? -41.68831 3.64436  -31.99155 1.000 53.14269  ? 268 MET A CE  1 
ATOM   2027 N N   . ASN A 1 269 ? -40.47058 0.59127  -27.69071 1.000 27.16024  ? 269 ASN A N   1 
ATOM   2028 C CA  . ASN A 1 269 ? -39.09834 0.23882  -27.35810 1.000 27.17024  ? 269 ASN A CA  1 
ATOM   2029 C C   . ASN A 1 269 ? -38.21052 1.39638  -27.79381 1.000 20.40024  ? 269 ASN A C   1 
ATOM   2030 O O   . ASN A 1 269 ? -38.10501 1.66161  -28.99043 1.000 20.29024  ? 269 ASN A O   1 
ATOM   2031 C CB  . ASN A 1 269 ? -38.74301 -1.05973 -28.09515 1.000 30.45024  ? 269 ASN A CB  1 
ATOM   2032 C CG  . ASN A 1 269 ? -37.34456 -1.61120 -27.76605 1.000 35.15024  ? 269 ASN A CG  1 
ATOM   2033 O OD1 . ASN A 1 269 ? -36.42323 -0.89256 -27.38255 1.000 31.40024  ? 269 ASN A OD1 1 
ATOM   2034 N ND2 . ASN A 1 269 ? -37.18938 -2.91639 -27.95582 1.000 39.42024  ? 269 ASN A ND2 1 
ATOM   2035 N N   . PHE A 1 270 ? -37.56329 2.08089  -26.83574 1.000 21.62122  ? 270 PHE A N   1 
ATOM   2036 C CA  . PHE A 1 270 ? -36.74439 3.24212  -27.19349 1.000 21.78122  ? 270 PHE A CA  1 
ATOM   2037 C C   . PHE A 1 270 ? -35.50568 2.84713  -27.98256 1.000 21.33122  ? 270 PHE A C   1 
ATOM   2038 O O   . PHE A 1 270 ? -35.02511 3.64234  -28.79853 1.000 21.63122  ? 270 PHE A O   1 
ATOM   2039 C CB  . PHE A 1 270 ? -36.27658 4.01751  -25.96264 1.000 20.97122  ? 270 PHE A CB  1 
ATOM   2040 C CG  . PHE A 1 270 ? -37.31072 4.90172  -25.33758 1.000 19.69122  ? 270 PHE A CG  1 
ATOM   2041 C CD1 . PHE A 1 270 ? -38.66517 4.59296  -25.38234 1.000 20.30122  ? 270 PHE A CD1 1 
ATOM   2042 C CD2 . PHE A 1 270 ? -36.90901 6.03537  -24.63843 1.000 20.79122  ? 270 PHE A CD2 1 
ATOM   2043 C CE1 . PHE A 1 270 ? -39.58793 5.40083  -24.76354 1.000 23.55122  ? 270 PHE A CE1 1 
ATOM   2044 C CE2 . PHE A 1 270 ? -37.82564 6.84398  -24.02717 1.000 21.12122  ? 270 PHE A CE2 1 
ATOM   2045 C CZ  . PHE A 1 270 ? -39.16345 6.53476  -24.07785 1.000 21.78122  ? 270 PHE A CZ  1 
ATOM   2046 N N   . ALA A 1 271 ? -34.95046 1.65308  -27.72273 1.000 18.71257  ? 271 ALA A N   1 
ATOM   2047 C CA  . ALA A 1 271 ? -33.73639 1.22300  -28.41409 1.000 23.82257  ? 271 ALA A CA  1 
ATOM   2048 C C   . ALA A 1 271 ? -33.92768 1.17690  -29.92271 1.000 26.46257  ? 271 ALA A C   1 
ATOM   2049 O O   . ALA A 1 271 ? -32.97806 1.43374  -30.67308 1.000 26.53257  ? 271 ALA A O   1 
ATOM   2050 C CB  . ALA A 1 271 ? -33.28629 -0.15010 -27.90874 1.000 26.73257  ? 271 ALA A CB  1 
ATOM   2051 N N   . ASN A 1 272 ? -35.14667 0.87598  -30.37780 1.000 24.68820  ? 272 ASN A N   1 
ATOM   2052 C CA  . ASN A 1 272 ? -35.47395 0.87441  -31.79641 1.000 32.12820  ? 272 ASN A CA  1 
ATOM   2053 C C   . ASN A 1 272 ? -35.70013 2.27529  -32.35762 1.000 31.20820  ? 272 ASN A C   1 
ATOM   2054 O O   . ASN A 1 272 ? -35.86207 2.40910  -33.57113 1.000 41.67820  ? 272 ASN A O   1 
ATOM   2055 C CB  . ASN A 1 272 ? -36.72767 0.02518  -32.05687 1.000 32.75820  ? 272 ASN A CB  1 
ATOM   2056 C CG  . ASN A 1 272 ? -36.55031 -1.43729 -31.66253 1.000 36.32820  ? 272 ASN A CG  1 
ATOM   2057 O OD1 . ASN A 1 272 ? -35.44125 -1.97400 -31.67789 1.000 39.33820  ? 272 ASN A OD1 1 
ATOM   2058 N ND2 . ASN A 1 272 ? -37.65276 -2.08470 -31.30319 1.000 40.98820  ? 272 ASN A ND2 1 
ATOM   2059 N N   . VAL A 1 273 ? -35.73327 3.30907  -31.51935 1.000 27.93780  ? 273 VAL A N   1 
ATOM   2060 C CA  . VAL A 1 273 ? -35.96789 4.68394  -31.96237 1.000 29.13780  ? 273 VAL A CA  1 
ATOM   2061 C C   . VAL A 1 273 ? -34.62870 5.41160  -31.99912 1.000 30.23780  ? 273 VAL A C   1 
ATOM   2062 O O   . VAL A 1 273 ? -34.43334 6.34834  -32.78285 1.000 27.95780  ? 273 VAL A O   1 
ATOM   2063 C CB  . VAL A 1 273 ? -36.97194 5.39150  -31.02777 1.000 30.37780  ? 273 VAL A CB  1 
ATOM   2064 C CG1 . VAL A 1 273 ? -37.26883 6.81583  -31.47964 1.000 40.15780  ? 273 VAL A CG1 1 
ATOM   2065 C CG2 . VAL A 1 273 ? -38.25703 4.60098  -30.94002 1.000 40.13780  ? 273 VAL A CG2 1 
ATOM   2066 N N   . PHE A 1 274 ? -33.68891 4.97107  -31.15537 1.000 33.75575  ? 274 PHE A N   1 
ATOM   2067 C CA  . PHE A 1 274 ? -32.40592 5.64294  -30.96942 1.000 24.52575  ? 274 PHE A CA  1 
ATOM   2068 C C   . PHE A 1 274 ? -31.22807 4.73172  -31.31553 1.000 25.06575  ? 274 PHE A C   1 
ATOM   2069 O O   . PHE A 1 274 ? -30.27969 4.61565  -30.53640 1.000 27.39575  ? 274 PHE A O   1 
ATOM   2070 C CB  . PHE A 1 274 ? -32.25623 6.11999  -29.52047 1.000 22.44575  ? 274 PHE A CB  1 
ATOM   2071 C CG  . PHE A 1 274 ? -33.23033 7.17923  -29.10951 1.000 20.85575  ? 274 PHE A CG  1 
ATOM   2072 C CD1 . PHE A 1 274 ? -32.92943 8.51415  -29.30648 1.000 23.07575  ? 274 PHE A CD1 1 
ATOM   2073 C CD2 . PHE A 1 274 ? -34.42794 6.84901  -28.49035 1.000 20.41575  ? 274 PHE A CD2 1 
ATOM   2074 C CE1 . PHE A 1 274 ? -33.81820 9.50343  -28.92101 1.000 20.75575  ? 274 PHE A CE1 1 
ATOM   2075 C CE2 . PHE A 1 274 ? -35.31762 7.82287  -28.10425 1.000 21.74575  ? 274 PHE A CE2 1 
ATOM   2076 C CZ  . PHE A 1 274 ? -35.00922 9.16201  -28.32734 1.000 23.26575  ? 274 PHE A CZ  1 
ATOM   2077 N N   . ILE A 1 275 ? -31.27091 4.08936  -32.48312 1.000 24.44515  ? 275 ILE A N   1 
ATOM   2078 C CA  . ILE A 1 275 ? -30.24926 3.12641  -32.89682 1.000 24.35515  ? 275 ILE A CA  1 
ATOM   2079 C C   . ILE A 1 275 ? -28.92616 3.83967  -33.10771 1.000 27.24515  ? 275 ILE A C   1 
ATOM   2080 O O   . ILE A 1 275 ? -28.87663 4.89555  -33.75376 1.000 23.19515  ? 275 ILE A O   1 
ATOM   2081 C CB  . ILE A 1 275 ? -30.67176 2.41472  -34.19378 1.000 32.59515  ? 275 ILE A CB  1 
ATOM   2082 C CG1 . ILE A 1 275 ? -32.16016 2.05852  -34.17818 1.000 39.08515  ? 275 ILE A CG1 1 
ATOM   2083 C CG2 . ILE A 1 275 ? -29.77150 1.21579  -34.46148 1.000 33.69515  ? 275 ILE A CG2 1 
ATOM   2084 C CD1 . ILE A 1 275 ? -33.07349 3.12496  -34.87266 1.000 32.58515  ? 275 ILE A CD1 1 
ATOM   2085 N N   . GLY A 1 276 ? -27.83817 3.25214  -32.59830 1.000 25.37533  ? 276 GLY A N   1 
ATOM   2086 C CA  . GLY A 1 276 ? -26.52747 3.85703  -32.70434 1.000 22.26533  ? 276 GLY A CA  1 
ATOM   2087 C C   . GLY A 1 276 ? -26.12987 4.73541  -31.53413 1.000 24.12533  ? 276 GLY A C   1 
ATOM   2088 O O   . GLY A 1 276 ? -24.93924 5.05274  -31.38836 1.000 24.13533  ? 276 GLY A O   1 
ATOM   2089 N N   . ALA A 1 277 ? -27.08445 5.14797  -30.70122 1.000 28.12266  ? 277 ALA A N   1 
ATOM   2090 C CA  . ALA A 1 277 ? -26.75995 5.89344  -29.49020 1.000 25.14266  ? 277 ALA A CA  1 
ATOM   2091 C C   . ALA A 1 277 ? -26.19291 4.95609  -28.41944 1.000 28.00266  ? 277 ALA A C   1 
ATOM   2092 O O   . ALA A 1 277 ? -26.49417 3.75586  -28.40400 1.000 22.54266  ? 277 ALA A O   1 
ATOM   2093 C CB  . ALA A 1 277 ? -27.99870 6.60633  -28.95494 1.000 25.03266  ? 277 ALA A CB  1 
ATOM   2094 N N   . ASN A 1 278 ? -25.33928 5.52209  -27.52997 1.000 23.26912  ? 278 ASN A N   1 
ATOM   2095 C CA  . ASN A 1 278 ? -24.83403 4.85968  -26.32145 1.000 23.38912  ? 278 ASN A CA  1 
ATOM   2096 C C   . ASN A 1 278 ? -26.00693 4.16577  -25.63480 1.000 18.45912  ? 278 ASN A C   1 
ATOM   2097 O O   . ASN A 1 278 ? -27.01725 4.81135  -25.33520 1.000 17.61912  ? 278 ASN A O   1 
ATOM   2098 C CB  . ASN A 1 278 ? -24.14732 5.88649  -25.40511 1.000 22.44912  ? 278 ASN A CB  1 
ATOM   2099 C CG  . ASN A 1 278 ? -23.40585 5.26121  -24.21425 1.000 22.96912  ? 278 ASN A CG  1 
ATOM   2100 O OD1 . ASN A 1 278 ? -23.78315 4.21439  -23.68973 1.000 20.87912  ? 278 ASN A OD1 1 
ATOM   2101 N ND2 . ASN A 1 278 ? -22.35265 5.94636  -23.76136 1.000 21.81912  ? 278 ASN A ND2 1 
ATOM   2102 N N   . PRO A 1 279 ? -25.94165 2.84264  -25.45132 1.000 18.93869  ? 279 PRO A N   1 
ATOM   2103 C CA  . PRO A 1 279 ? -27.06635 2.13036  -24.82420 1.000 18.16869  ? 279 PRO A CA  1 
ATOM   2104 C C   . PRO A 1 279 ? -27.38741 2.61837  -23.41583 1.000 14.82869  ? 279 PRO A C   1 
ATOM   2105 O O   . PRO A 1 279 ? -28.54001 2.51376  -22.98098 1.000 14.18869  ? 279 PRO A O   1 
ATOM   2106 C CB  . PRO A 1 279 ? -26.59521 0.66376  -24.79964 1.000 21.98869  ? 279 PRO A CB  1 
ATOM   2107 C CG  . PRO A 1 279 ? -25.37681 0.59814  -25.62700 1.000 23.35869  ? 279 PRO A CG  1 
ATOM   2108 C CD  . PRO A 1 279 ? -24.78452 1.96277  -25.70441 1.000 24.48869  ? 279 PRO A CD  1 
ATOM   2109 N N   . LEU A 1 280 ? -26.40005 3.12565  -22.67990 1.000 14.29690  ? 280 LEU A N   1 
ATOM   2110 C CA  . LEU A 1 280 ? -26.70993 3.65767  -21.35587 1.000 15.65690  ? 280 LEU A CA  1 
ATOM   2111 C C   . LEU A 1 280 ? -27.42772 4.99635  -21.46211 1.000 14.89690  ? 280 LEU A C   1 
ATOM   2112 O O   . LEU A 1 280 ? -28.23188 5.33776  -20.58280 1.000 14.01690  ? 280 LEU A O   1 
ATOM   2113 C CB  . LEU A 1 280 ? -25.43356 3.78994  -20.53379 1.000 18.34690  ? 280 LEU A CB  1 
ATOM   2114 C CG  . LEU A 1 280 ? -24.68245 2.47971  -20.23555 1.000 20.21690  ? 280 LEU A CG  1 
ATOM   2115 C CD1 . LEU A 1 280 ? -23.33207 2.79098  -19.58884 1.000 20.31690  ? 280 LEU A CD1 1 
ATOM   2116 C CD2 . LEU A 1 280 ? -25.51108 1.59266  -19.34855 1.000 18.65690  ? 280 LEU A CD2 1 
ATOM   2117 N N   . ALA A 1 281 ? -27.14758 5.76055  -22.53009 1.000 15.38403  ? 281 ALA A N   1 
ATOM   2118 C CA  . ALA A 1 281 ? -27.92017 6.97145  -22.80815 1.000 16.71403  ? 281 ALA A CA  1 
ATOM   2119 C C   . ALA A 1 281 ? -29.38856 6.64533  -23.03325 1.000 14.09403  ? 281 ALA A C   1 
ATOM   2120 O O   . ALA A 1 281 ? -30.27272 7.28649  -22.45666 1.000 12.84403  ? 281 ALA A O   1 
ATOM   2121 C CB  . ALA A 1 281 ? -27.34300 7.70722  -24.02391 1.000 18.30403  ? 281 ALA A CB  1 
ATOM   2122 N N   . VAL A 1 282 ? -29.67014 5.63860  -23.86915 1.000 13.59007  ? 282 VAL A N   1 
ATOM   2123 C CA  . VAL A 1 282 ? -31.05343 5.26697  -24.15447 1.000 14.27007  ? 282 VAL A CA  1 
ATOM   2124 C C   . VAL A 1 282 ? -31.74191 4.75996  -22.89103 1.000 14.64007  ? 282 VAL A C   1 
ATOM   2125 O O   . VAL A 1 282 ? -32.92983 5.03163  -22.66156 1.000 15.86007  ? 282 VAL A O   1 
ATOM   2126 C CB  . VAL A 1 282 ? -31.10970 4.22484  -25.29495 1.000 16.28007  ? 282 VAL A CB  1 
ATOM   2127 C CG1 . VAL A 1 282 ? -32.55450 3.85639  -25.62909 1.000 20.00007  ? 282 VAL A CG1 1 
ATOM   2128 C CG2 . VAL A 1 282 ? -30.42538 4.76772  -26.52520 1.000 19.66007  ? 282 VAL A CG2 1 
ATOM   2129 N N   . ASP A 1 283 ? -31.00762 4.02144  -22.05185 1.000 16.27526  ? 283 ASP A N   1 
ATOM   2130 C CA  . ASP A 1 283 ? -31.58785 3.51353  -20.81046 1.000 18.45526  ? 283 ASP A CA  1 
ATOM   2131 C C   . ASP A 1 283 ? -32.01414 4.66362  -19.90000 1.000 15.42526  ? 283 ASP A C   1 
ATOM   2132 O O   . ASP A 1 283 ? -33.12579 4.67079  -19.36340 1.000 18.02526  ? 283 ASP A O   1 
ATOM   2133 C CB  . ASP A 1 283 ? -30.57419 2.60500  -20.10750 1.000 20.79526  ? 283 ASP A CB  1 
ATOM   2134 C CG  . ASP A 1 283 ? -31.13337 1.98690  -18.83263 1.000 27.74526  ? 283 ASP A CG  1 
ATOM   2135 O OD1 . ASP A 1 283 ? -31.82274 0.94682  -18.92468 1.000 34.09526  ? 283 ASP A OD1 1 
ATOM   2136 O OD2 . ASP A 1 283 ? -30.91175 2.56586  -17.74445 1.000 25.58526  ? 283 ASP A OD2 1 
ATOM   2137 N N   . LEU A 1 284 ? -31.15325 5.67090  -19.75868 1.000 15.74200  ? 284 LEU A N   1 
ATOM   2138 C CA  . LEU A 1 284 ? -31.49797 6.84236  -18.94812 1.000 14.19200  ? 284 LEU A CA  1 
ATOM   2139 C C   . LEU A 1 284 ? -32.69286 7.59563  -19.53324 1.000 13.56200  ? 284 LEU A C   1 
ATOM   2140 O O   . LEU A 1 284 ? -33.59495 8.01665  -18.79643 1.000 13.55200  ? 284 LEU A O   1 
ATOM   2141 C CB  . LEU A 1 284 ? -30.26938 7.74689  -18.83965 1.000 13.84200  ? 284 LEU A CB  1 
ATOM   2142 C CG  . LEU A 1 284 ? -30.43500 9.02417  -18.00718 1.000 13.94200  ? 284 LEU A CG  1 
ATOM   2143 C CD1 . LEU A 1 284 ? -30.72888 8.69142  -16.55058 1.000 14.23200  ? 284 LEU A CD1 1 
ATOM   2144 C CD2 . LEU A 1 284 ? -29.16504 9.80926  -18.12409 1.000 15.84200  ? 284 LEU A CD2 1 
ATOM   2145 N N   . LEU A 1 285 ? -32.73063 7.74702  -20.86597 1.000 13.71431  ? 285 LEU A N   1 
ATOM   2146 C CA  . LEU A 1 285 ? -33.88136 8.35838  -21.53469 1.000 14.73431  ? 285 LEU A CA  1 
ATOM   2147 C C   . LEU A 1 285 ? -35.18537 7.64782  -21.19216 1.000 13.26431  ? 285 LEU A C   1 
ATOM   2148 O O   . LEU A 1 285 ? -36.20724 8.30464  -20.93537 1.000 13.13431  ? 285 LEU A O   1 
ATOM   2149 C CB  . LEU A 1 285 ? -33.67246 8.34702  -23.05470 1.000 17.39431  ? 285 LEU A CB  1 
ATOM   2150 C CG  . LEU A 1 285 ? -32.97716 9.53745  -23.68129 1.000 22.67431  ? 285 LEU A CG  1 
ATOM   2151 C CD1 . LEU A 1 285 ? -32.85654 9.34101  -25.20263 1.000 21.78431  ? 285 LEU A CD1 1 
ATOM   2152 C CD2 . LEU A 1 285 ? -33.77285 10.79454 -23.34746 1.000 22.70431  ? 285 LEU A CD2 1 
ATOM   2153 N N   . GLU A 1 286 ? -35.17297 6.30278  -21.17727 1.000 12.75090  ? 286 GLU A N   1 
ATOM   2154 C CA  . GLU A 1 286 ? -36.37706 5.56106  -20.78602 1.000 17.33090  ? 286 GLU A CA  1 
ATOM   2155 C C   . GLU A 1 286 ? -36.80600 5.90291  -19.36205 1.000 15.30090  ? 286 GLU A C   1 
ATOM   2156 O O   . GLU A 1 286 ? -37.99937 5.90638  -19.05369 1.000 18.94090  ? 286 GLU A O   1 
ATOM   2157 C CB  . GLU A 1 286 ? -36.15014 4.04355  -20.89047 1.000 22.17090  ? 286 GLU A CB  1 
ATOM   2158 C CG  . GLU A 1 286 ? -36.05412 3.43304  -22.28963 1.000 29.39090  ? 286 GLU A CG  1 
ATOM   2159 C CD  . GLU A 1 286 ? -37.28919 2.60566  -22.68068 1.000 34.96090  ? 286 GLU A CD  1 
ATOM   2160 O OE1 . GLU A 1 286 ? -38.35090 2.76679  -22.02983 1.000 34.27090  ? 286 GLU A OE1 1 
ATOM   2161 O OE2 . GLU A 1 286 ? -37.20413 1.80068  -23.64903 1.000 38.17090  ? 286 GLU A OE2 1 
ATOM   2162 N N   . LYS A 1 287 ? -35.85256 6.20907  -18.48321 1.000 15.23372  ? 287 LYS A N   1 
ATOM   2163 C CA  . LYS A 1 287 ? -36.21112 6.47992  -17.09511 1.000 15.19372  ? 287 LYS A CA  1 
ATOM   2164 C C   . LYS A 1 287 ? -36.69586 7.90440  -16.87447 1.000 14.98372  ? 287 LYS A C   1 
ATOM   2165 O O   . LYS A 1 287 ? -37.40783 8.16050  -15.89328 1.000 12.69372  ? 287 LYS A O   1 
ATOM   2166 C CB  . LYS A 1 287 ? -35.01802 6.18128  -16.19679 1.000 16.37372  ? 287 LYS A CB  1 
ATOM   2167 C CG  . LYS A 1 287 ? -34.77484 4.67149  -16.02527 1.000 20.88372  ? 287 LYS A CG  1 
ATOM   2168 C CD  . LYS A 1 287 ? -33.34758 4.39649  -15.65171 1.000 25.87372  ? 287 LYS A CD  1 
ATOM   2169 C CE  . LYS A 1 287 ? -33.14522 2.93496  -15.27403 1.000 36.46372  ? 287 LYS A CE  1 
ATOM   2170 N NZ  . LYS A 1 287 ? -33.84917 2.00276  -16.21167 1.000 40.64372  ? 287 LYS A NZ  1 
ATOM   2171 N N   . MET A 1 288 ? -36.33020 8.83203  -17.75441 1.000 13.58003  ? 288 MET A N   1 
ATOM   2172 C CA  . MET A 1 288 ? -36.77106 10.21584 -17.61860 1.000 14.62003  ? 288 MET A CA  1 
ATOM   2173 C C   . MET A 1 288 ? -38.11818 10.46752 -18.28656 1.000 13.42003  ? 288 MET A C   1 
ATOM   2174 O O   . MET A 1 288 ? -38.90621 11.28544 -17.80657 1.000 14.06003  ? 288 MET A O   1 
ATOM   2175 C CB  . MET A 1 288 ? -35.72153 11.14723 -18.22562 1.000 14.19003  ? 288 MET A CB  1 
ATOM   2176 C CG  . MET A 1 288 ? -34.38955 11.13820 -17.49151 1.000 17.73003  ? 288 MET A CG  1 
ATOM   2177 S SD  . MET A 1 288 ? -33.19036 12.14869 -18.39782 1.000 23.22003  ? 288 MET A SD  1 
ATOM   2178 C CE  . MET A 1 288 ? -31.94129 12.40754 -17.16002 1.000 22.29003  ? 288 MET A CE  1 
ATOM   2179 N N   . LEU A 1 289 ? -38.37304 9.81166  -19.41124 1.000 16.00781  ? 289 LEU A N   1 
ATOM   2180 C CA  . LEU A 1 289 ? -39.58387 10.04113 -20.20083 1.000 14.85781  ? 289 LEU A CA  1 
ATOM   2181 C C   . LEU A 1 289 ? -40.64757 8.99860  -19.89301 1.000 17.06781  ? 289 LEU A C   1 
ATOM   2182 O O   . LEU A 1 289 ? -41.19453 8.34409  -20.77458 1.000 20.67781  ? 289 LEU A O   1 
ATOM   2183 C CB  . LEU A 1 289 ? -39.24867 10.06342 -21.67853 1.000 15.04781  ? 289 LEU A CB  1 
ATOM   2184 C CG  . LEU A 1 289 ? -38.24338 11.15570 -22.07518 1.000 16.11781  ? 289 LEU A CG  1 
ATOM   2185 C CD1 . LEU A 1 289 ? -37.87541 10.98886 -23.52822 1.000 15.54781  ? 289 LEU A CD1 1 
ATOM   2186 C CD2 . LEU A 1 289 ? -38.82934 12.55075 -21.81210 1.000 16.49781  ? 289 LEU A CD2 1 
ATOM   2187 N N   . VAL A 1 290 ? -40.92231 8.83144  -18.62259 1.000 21.34309  ? 290 VAL A N   1 
ATOM   2188 C CA  . VAL A 1 290 ? -42.02738 8.01292  -18.14957 1.000 21.74309  ? 290 VAL A CA  1 
ATOM   2189 C C   . VAL A 1 290 ? -43.22481 8.93202  -17.99997 1.000 20.43309  ? 290 VAL A C   1 
ATOM   2190 O O   . VAL A 1 290 ? -43.08871 10.05965 -17.50969 1.000 18.06309  ? 290 VAL A O   1 
ATOM   2191 C CB  . VAL A 1 290 ? -41.67029 7.32934  -16.81451 1.000 26.23309  ? 290 VAL A CB  1 
ATOM   2192 C CG1 . VAL A 1 290 ? -42.77691 6.39021  -16.38328 1.000 31.24309  ? 290 VAL A CG1 1 
ATOM   2193 C CG2 . VAL A 1 290 ? -40.36866 6.58257  -16.93886 1.000 26.99309  ? 290 VAL A CG2 1 
ATOM   2194 N N   . LEU A 1 291 ? -44.40197 8.46230  -18.42652 1.000 20.84867  ? 291 LEU A N   1 
ATOM   2195 C CA  . LEU A 1 291 ? -45.57890 9.32610  -18.45466 1.000 20.84867  ? 291 LEU A CA  1 
ATOM   2196 C C   . LEU A 1 291 ? -46.04453 9.69653  -17.05391 1.000 23.59867  ? 291 LEU A C   1 
ATOM   2197 O O   . LEU A 1 291 ? -46.40372 10.85274 -16.80042 1.000 20.12867  ? 291 LEU A O   1 
ATOM   2198 C CB  . LEU A 1 291 ? -46.70608 8.64065  -19.23149 1.000 25.02867  ? 291 LEU A CB  1 
ATOM   2199 C CG  . LEU A 1 291 ? -47.88555 9.53941  -19.58084 1.000 28.69867  ? 291 LEU A CG  1 
ATOM   2200 C CD1 . LEU A 1 291 ? -47.43387 10.73400 -20.38876 1.000 28.95867  ? 291 LEU A CD1 1 
ATOM   2201 C CD2 . LEU A 1 291 ? -48.89386 8.73439  -20.35034 1.000 34.43867  ? 291 LEU A CD2 1 
ATOM   2202 N N   . ASP A 1 292 ? -46.07238 8.72850  -16.13868 1.000 22.99321  ? 292 ASP A N   1 
ATOM   2203 C CA  . ASP A 1 292 ? -46.45899 8.97457  -14.75257 1.000 27.45321  ? 292 ASP A CA  1 
ATOM   2204 C C   . ASP A 1 292 ? -45.29194 9.67024  -14.05783 1.000 24.17321  ? 292 ASP A C   1 
ATOM   2205 O O   . ASP A 1 292 ? -44.22455 9.07221  -13.87888 1.000 21.81321  ? 292 ASP A O   1 
ATOM   2206 C CB  . ASP A 1 292 ? -46.82486 7.65419  -14.06759 1.000 29.54321  ? 292 ASP A CB  1 
ATOM   2207 C CG  . ASP A 1 292 ? -47.49070 7.83844  -12.68659 1.000 32.56321  ? 292 ASP A CG  1 
ATOM   2208 O OD1 . ASP A 1 292 ? -47.19747 8.81732  -11.95784 1.000 28.75321  ? 292 ASP A OD1 1 
ATOM   2209 O OD2 . ASP A 1 292 ? -48.30265 6.96045  -12.31291 1.000 35.73321  ? 292 ASP A OD2 1 
ATOM   2210 N N   . SER A 1 293 ? -45.49565 10.92494 -13.64971 1.000 22.81067  ? 293 SER A N   1 
ATOM   2211 C CA  . SER A 1 293 ? -44.40615 11.68005 -13.03856 1.000 26.12067  ? 293 SER A CA  1 
ATOM   2212 C C   . SER A 1 293 ? -43.92972 11.07329 -11.71591 1.000 25.53067  ? 293 SER A C   1 
ATOM   2213 O O   . SER A 1 293 ? -42.76123 11.26124 -11.35020 1.000 24.69067  ? 293 SER A O   1 
ATOM   2214 C CB  . SER A 1 293 ? -44.82344 13.14204 -12.83516 1.000 24.34067  ? 293 SER A CB  1 
ATOM   2215 O OG  . SER A 1 293 ? -45.83685 13.25911 -11.86515 1.000 27.30067  ? 293 SER A OG  1 
ATOM   2216 N N   . ASP A 1 294 ? -44.77664 10.31114 -11.01326 1.000 24.35533  ? 294 ASP A N   1 
ATOM   2217 C CA  . ASP A 1 294 ? -44.30629 9.62397  -9.81141  1.000 24.80533  ? 294 ASP A CA  1 
ATOM   2218 C C   . ASP A 1 294 ? -43.32011 8.49685  -10.12417 1.000 23.14533  ? 294 ASP A C   1 
ATOM   2219 O O   . ASP A 1 294 ? -42.59832 8.05396  -9.22672  1.000 22.39533  ? 294 ASP A O   1 
ATOM   2220 C CB  . ASP A 1 294 ? -45.48359 9.05646  -9.01828  1.000 30.11533  ? 294 ASP A CB  1 
ATOM   2221 C CG  . ASP A 1 294 ? -46.40660 10.14061 -8.46735  1.000 35.94533  ? 294 ASP A CG  1 
ATOM   2222 O OD1 . ASP A 1 294 ? -45.92657 11.25414 -8.15972  1.000 38.56533  ? 294 ASP A OD1 1 
ATOM   2223 O OD2 . ASP A 1 294 ? -47.62053 9.87090  -8.34632  1.000 41.83533  ? 294 ASP A OD2 1 
ATOM   2224 N N   . LYS A 1 295 ? -43.26183 8.03342  -11.36604 1.000 18.67342  ? 295 LYS A N   1 
ATOM   2225 C CA  . LYS A 1 295 ? -42.37760 6.93747  -11.74336 1.000 23.50342  ? 295 LYS A CA  1 
ATOM   2226 C C   . LYS A 1 295 ? -41.11250 7.40592  -12.45607 1.000 20.15342  ? 295 LYS A C   1 
ATOM   2227 O O   . LYS A 1 295 ? -40.25680 6.57152  -12.77794 1.000 18.72342  ? 295 LYS A O   1 
ATOM   2228 C CB  . LYS A 1 295 ? -43.13237 5.93708  -12.62982 1.000 26.20342  ? 295 LYS A CB  1 
ATOM   2229 C CG  . LYS A 1 295 ? -43.79292 4.77150  -11.87674 1.000 32.91342  ? 295 LYS A CG  1 
ATOM   2230 C CD  . LYS A 1 295 ? -44.80992 5.22520  -10.86008 1.000 40.37342  ? 295 LYS A CD  1 
ATOM   2231 C CE  . LYS A 1 295 ? -45.30568 4.07488  -10.00159 1.000 45.68342  ? 295 LYS A CE  1 
ATOM   2232 N NZ  . LYS A 1 295 ? -46.17045 3.15103  -10.78315 1.000 48.87342  ? 295 LYS A NZ  1 
ATOM   2233 N N   . ARG A 1 296 ? -40.98441 8.70553  -12.74505 1.000 18.61310  ? 296 ARG A N   1 
ATOM   2234 C CA  . ARG A 1 296 ? -39.77269 9.20128  -13.38248 1.000 17.71310  ? 296 ARG A CA  1 
ATOM   2235 C C   . ARG A 1 296 ? -38.62215 9.19670  -12.38988 1.000 15.95310  ? 296 ARG A C   1 
ATOM   2236 O O   . ARG A 1 296 ? -38.80718 9.40101  -11.18410 1.000 17.01310  ? 296 ARG A O   1 
ATOM   2237 C CB  . ARG A 1 296 ? -39.96552 10.62602 -13.92193 1.000 18.84310  ? 296 ARG A CB  1 
ATOM   2238 C CG  . ARG A 1 296 ? -40.88618 10.73924 -15.10337 1.000 23.81310  ? 296 ARG A CG  1 
ATOM   2239 C CD  . ARG A 1 296 ? -41.19288 12.20341 -15.44916 1.000 20.04310  ? 296 ARG A CD  1 
ATOM   2240 N NE  . ARG A 1 296 ? -42.46427 12.27944 -16.15443 1.000 19.53310  ? 296 ARG A NE  1 
ATOM   2241 C CZ  . ARG A 1 296 ? -43.26790 13.33147 -16.13424 1.000 22.06310  ? 296 ARG A CZ  1 
ATOM   2242 N NH1 . ARG A 1 296 ? -42.93831 14.44436 -15.48749 1.000 24.12310  ? 296 ARG A NH1 1 
ATOM   2243 N NH2 . ARG A 1 296 ? -44.43338 13.26698 -16.77430 1.000 22.99310  ? 296 ARG A NH2 1 
ATOM   2244 N N   . ILE A 1 297 ? -37.41753 9.00118  -12.92058 1.000 14.91070  ? 297 ILE A N   1 
ATOM   2245 C CA  . ILE A 1 297 ? -36.20838 9.07441  -12.10941 1.000 15.47070  ? 297 ILE A CA  1 
ATOM   2246 C C   . ILE A 1 297 ? -36.02801 10.49645 -11.56250 1.000 15.99070  ? 297 ILE A C   1 
ATOM   2247 O O   . ILE A 1 297 ? -36.36189 11.48240 -12.22740 1.000 15.43070  ? 297 ILE A O   1 
ATOM   2248 C CB  . ILE A 1 297 ? -35.02507 8.60025  -12.97368 1.000 13.81070  ? 297 ILE A CB  1 
ATOM   2249 C CG1 . ILE A 1 297 ? -33.80311 8.28083  -12.14860 1.000 15.35070  ? 297 ILE A CG1 1 
ATOM   2250 C CG2 . ILE A 1 297 ? -34.63192 9.61529  -14.08411 1.000 15.34070  ? 297 ILE A CG2 1 
ATOM   2251 C CD1 . ILE A 1 297 ? -32.76590 7.50308  -12.93441 1.000 16.00070  ? 297 ILE A CD1 1 
ATOM   2252 N N   . THR A 1 298 ? -35.52625 10.61040 -10.32967 1.000 15.07613  ? 298 THR A N   1 
ATOM   2253 C CA  . THR A 1 298 ? -35.23433 11.92013 -9.75113  1.000 16.10613  ? 298 THR A CA  1 
ATOM   2254 C C   . THR A 1 298 ? -33.84404 12.38070 -10.19201 1.000 14.68613  ? 298 THR A C   1 
ATOM   2255 O O   . THR A 1 298 ? -33.04650 11.59637 -10.71168 1.000 14.80613  ? 298 THR A O   1 
ATOM   2256 C CB  . THR A 1 298 ? -35.29004 11.86993 -8.21855  1.000 16.27613  ? 298 THR A CB  1 
ATOM   2257 O OG1 . THR A 1 298 ? -34.17235 11.11678 -7.74402  1.000 14.79613  ? 298 THR A OG1 1 
ATOM   2258 C CG2 . THR A 1 298 ? -36.56445 11.23044 -7.72073  1.000 18.37613  ? 298 THR A CG2 1 
ATOM   2259 N N   . ALA A 1 299 ? -33.53263 13.66221 -9.94973  1.000 12.43826  ? 299 ALA A N   1 
ATOM   2260 C CA  . ALA A 1 299 ? -32.20156 14.16168 -10.30631 1.000 13.13826  ? 299 ALA A CA  1 
ATOM   2261 C C   . ALA A 1 299 ? -31.10992 13.44739 -9.51075  1.000 12.93826  ? 299 ALA A C   1 
ATOM   2262 O O   . ALA A 1 299 ? -30.07197 13.06800 -10.07192 1.000 11.60826  ? 299 ALA A O   1 
ATOM   2263 C CB  . ALA A 1 299 ? -32.11588 15.68310 -10.09240 1.000 13.86826  ? 299 ALA A CB  1 
ATOM   2264 N N   . ALA A 1 300 ? -31.33008 13.25551 -8.20213  1.000 12.59032  ? 300 ALA A N   1 
ATOM   2265 C CA  . ALA A 1 300 ? -30.35328 12.54332 -7.37512  1.000 14.97032  ? 300 ALA A CA  1 
ATOM   2266 C C   . ALA A 1 300 ? -30.11250 11.12497 -7.88300  1.000 14.74032  ? 300 ALA A C   1 
ATOM   2267 O O   . ALA A 1 300 ? -28.96517 10.67978 -7.96347  1.000 14.93032  ? 300 ALA A O   1 
ATOM   2268 C CB  . ALA A 1 300 ? -30.81122 12.50085 -5.91683  1.000 15.76032  ? 300 ALA A CB  1 
ATOM   2269 N N   . GLN A 1 301 ? -31.18291 10.40838 -8.24078  1.000 15.49976  ? 301 GLN A N   1 
ATOM   2270 C CA  . GLN A 1 301 ? -31.04295 9.04290  -8.74822  1.000 15.60976  ? 301 GLN A CA  1 
ATOM   2271 C C   . GLN A 1 301 ? -30.34826 9.01658  -10.10615 1.000 14.34976  ? 301 GLN A C   1 
ATOM   2272 O O   . GLN A 1 301 ? -29.50984 8.14250  -10.35648 1.000 13.22976  ? 301 GLN A O   1 
ATOM   2273 C CB  . GLN A 1 301 ? -32.42190 8.36801  -8.85218  1.000 21.15976  ? 301 GLN A CB  1 
ATOM   2274 C CG  . GLN A 1 301 ? -33.12013 8.06037  -7.53095  1.000 24.16976  ? 301 GLN A CG  1 
ATOM   2275 C CD  . GLN A 1 301 ? -34.59530 7.70642  -7.70271  1.000 27.20976  ? 301 GLN A CD  1 
ATOM   2276 O OE1 . GLN A 1 301 ? -35.22678 8.06622  -8.69268  1.000 22.23976  ? 301 GLN A OE1 1 
ATOM   2277 N NE2 . GLN A 1 301 ? -35.14913 6.99538  -6.72617  1.000 33.35976  ? 301 GLN A NE2 1 
ATOM   2278 N N   . ALA A 1 302 ? -30.67738 9.96781  -10.99579 1.000 13.14859  ? 302 ALA A N   1 
ATOM   2279 C CA  . ALA A 1 302 ? -30.06372 9.98966  -12.32174 1.000 13.84859  ? 302 ALA A CA  1 
ATOM   2280 C C   . ALA A 1 302 ? -28.55979 10.24610 -12.25521 1.000 13.24859  ? 302 ALA A C   1 
ATOM   2281 O O   . ALA A 1 302 ? -27.80423 9.70996  -13.06858 1.000 11.17859  ? 302 ALA A O   1 
ATOM   2282 C CB  . ALA A 1 302 ? -30.76519 11.03843 -13.19478 1.000 12.76859  ? 302 ALA A CB  1 
ATOM   2283 N N   . LEU A 1 303 ? -28.09570 11.03328 -11.28162 1.000 12.22608  ? 303 LEU A N   1 
ATOM   2284 C CA  . LEU A 1 303 ? -26.65862 11.26582 -11.14259 1.000 12.78608  ? 303 LEU A CA  1 
ATOM   2285 C C   . LEU A 1 303 ? -25.89089 9.97631  -10.86392 1.000 12.01608  ? 303 LEU A C   1 
ATOM   2286 O O   . LEU A 1 303 ? -24.71122 9.87086  -11.21509 1.000 12.39608  ? 303 LEU A O   1 
ATOM   2287 C CB  . LEU A 1 303 ? -26.40813 12.26453 -10.01451 1.000 13.55608  ? 303 LEU A CB  1 
ATOM   2288 C CG  . LEU A 1 303 ? -26.89543 13.68888 -10.27219 1.000 14.15608  ? 303 LEU A CG  1 
ATOM   2289 C CD1 . LEU A 1 303 ? -26.80830 14.45134 -8.97715  1.000 16.39608  ? 303 LEU A CD1 1 
ATOM   2290 C CD2 . LEU A 1 303 ? -26.01840 14.33399 -11.33767 1.000 13.91608  ? 303 LEU A CD2 1 
ATOM   2291 N N   . ALA A 1 304 ? -26.53904 9.00465  -10.22495 1.000 14.74917  ? 304 ALA A N   1 
ATOM   2292 C CA  . ALA A 1 304 ? -25.96594 7.69519  -9.93457  1.000 17.50917  ? 304 ALA A CA  1 
ATOM   2293 C C   . ALA A 1 304 ? -26.09103 6.71240  -11.09934 1.000 18.68917  ? 304 ALA A C   1 
ATOM   2294 O O   . ALA A 1 304 ? -25.63354 5.57182  -10.97493 1.000 17.93917  ? 304 ALA A O   1 
ATOM   2295 C CB  . ALA A 1 304 ? -26.63801 7.08949  -8.69460  1.000 15.57917  ? 304 ALA A CB  1 
ATOM   2296 N N   . HIS A 1 305 ? -26.69331 7.11547  -12.21648 1.000 15.24344  ? 305 HIS A N   1 
ATOM   2297 C CA  . HIS A 1 305 ? -26.84418 6.21305  -13.36135 1.000 16.80344  ? 305 HIS A CA  1 
ATOM   2298 C C   . HIS A 1 305 ? -25.49452 5.98427  -14.05198 1.000 14.84344  ? 305 HIS A C   1 
ATOM   2299 O O   . HIS A 1 305 ? -24.62982 6.87298  -14.09194 1.000 14.75344  ? 305 HIS A O   1 
ATOM   2300 C CB  . HIS A 1 305 ? -27.88404 6.79189  -14.33466 1.000 16.80344  ? 305 HIS A CB  1 
ATOM   2301 C CG  . HIS A 1 305 ? -28.29040 5.86775  -15.44756 1.000 15.94344  ? 305 HIS A CG  1 
ATOM   2302 N ND1 . HIS A 1 305 ? -27.49164 5.62765  -16.54182 1.000 14.50344  ? 305 HIS A ND1 1 
ATOM   2303 C CD2 . HIS A 1 305 ? -29.43605 5.17615  -15.65961 1.000 17.73344  ? 305 HIS A CD2 1 
ATOM   2304 C CE1 . HIS A 1 305 ? -28.11622 4.81186  -17.37463 1.000 16.49344  ? 305 HIS A CE1 1 
ATOM   2305 N NE2 . HIS A 1 305 ? -29.30302 4.52726  -16.86660 1.000 15.38344  ? 305 HIS A NE2 1 
ATOM   2306 N N   . ALA A 1 306 ? -25.31193 4.76560  -14.59693 1.000 14.69842  ? 306 ALA A N   1 
ATOM   2307 C CA  . ALA A 1 306 ? -24.01521 4.36799  -15.16449 1.000 17.23842  ? 306 ALA A CA  1 
ATOM   2308 C C   . ALA A 1 306 ? -23.55781 5.24872  -16.32837 1.000 15.29842  ? 306 ALA A C   1 
ATOM   2309 O O   . ALA A 1 306 ? -22.34937 5.33507  -16.58995 1.000 16.98842  ? 306 ALA A O   1 
ATOM   2310 C CB  . ALA A 1 306 ? -24.06788 2.90590  -15.63741 1.000 20.18842  ? 306 ALA A CB  1 
ATOM   2311 N N   . TYR A 1 307 ? -24.48526 5.92305  -17.01236 1.000 13.89792  ? 307 TYR A N   1 
ATOM   2312 C CA  . TYR A 1 307 ? -24.10605 6.84411  -18.08863 1.000 14.02792  ? 307 TYR A CA  1 
ATOM   2313 C C   . TYR A 1 307 ? -23.11601 7.91114  -17.61596 1.000 14.62792  ? 307 TYR A C   1 
ATOM   2314 O O   . TYR A 1 307 ? -22.23463 8.31222  -18.38269 1.000 13.92792  ? 307 TYR A O   1 
ATOM   2315 C CB  . TYR A 1 307 ? -25.37653 7.48018  -18.66154 1.000 17.07792  ? 307 TYR A CB  1 
ATOM   2316 C CG  . TYR A 1 307 ? -25.17738 8.33237  -19.89529 1.000 18.37792  ? 307 TYR A CG  1 
ATOM   2317 C CD1 . TYR A 1 307 ? -24.52713 7.83197  -21.01736 1.000 17.76792  ? 307 TYR A CD1 1 
ATOM   2318 C CD2 . TYR A 1 307 ? -25.67904 9.63289  -19.95209 1.000 20.15792  ? 307 TYR A CD2 1 
ATOM   2319 C CE1 . TYR A 1 307 ? -24.35381 8.61327  -22.15888 1.000 19.82792  ? 307 TYR A CE1 1 
ATOM   2320 C CE2 . TYR A 1 307 ? -25.49951 10.41885 -21.07738 1.000 20.07792  ? 307 TYR A CE2 1 
ATOM   2321 C CZ  . TYR A 1 307 ? -24.85552 9.89909  -22.18474 1.000 21.02792  ? 307 TYR A CZ  1 
ATOM   2322 O OH  . TYR A 1 307 ? -24.68004 10.67522 -23.31311 1.000 20.79792  ? 307 TYR A OH  1 
ATOM   2323 N N   . PHE A 1 308 ? -23.18267 8.31257  -16.33820 1.000 13.56707  ? 308 PHE A N   1 
ATOM   2324 C CA  . PHE A 1 308 ? -22.35785 9.38768  -15.79118 1.000 14.75707  ? 308 PHE A CA  1 
ATOM   2325 C C   . PHE A 1 308 ? -21.18362 8.89314  -14.96107 1.000 18.39707  ? 308 PHE A C   1 
ATOM   2326 O O   . PHE A 1 308 ? -20.60734 9.68567  -14.20485 1.000 18.56707  ? 308 PHE A O   1 
ATOM   2327 C CB  . PHE A 1 308 ? -23.20233 10.32994 -14.92968 1.000 14.35707  ? 308 PHE A CB  1 
ATOM   2328 C CG  . PHE A 1 308 ? -24.37097 10.89867 -15.65244 1.000 11.87707  ? 308 PHE A CG  1 
ATOM   2329 C CD1 . PHE A 1 308 ? -24.18761 11.71329 -16.75571 1.000 12.63707  ? 308 PHE A CD1 1 
ATOM   2330 C CD2 . PHE A 1 308 ? -25.64588 10.60721 -15.23452 1.000 12.80707  ? 308 PHE A CD2 1 
ATOM   2331 C CE1 . PHE A 1 308 ? -25.27102 12.23680 -17.45498 1.000 11.61707  ? 308 PHE A CE1 1 
ATOM   2332 C CE2 . PHE A 1 308 ? -26.73497 11.11761 -15.91702 1.000 12.67707  ? 308 PHE A CE2 1 
ATOM   2333 C CZ  . PHE A 1 308 ? -26.53648 11.94409 -17.03780 1.000 11.39707  ? 308 PHE A CZ  1 
ATOM   2334 N N   . ALA A 1 309 ? -20.79861 7.61757  -15.11530 1.000 18.38399  ? 309 ALA A N   1 
ATOM   2335 C CA  . ALA A 1 309 ? -19.73865 7.01336  -14.30693 1.000 20.84399  ? 309 ALA A CA  1 
ATOM   2336 C C   . ALA A 1 309 ? -18.43475 7.78985  -14.36156 1.000 21.75399  ? 309 ALA A C   1 
ATOM   2337 O O   . ALA A 1 309 ? -17.70772 7.84736  -13.36392 1.000 22.64399  ? 309 ALA A O   1 
ATOM   2338 C CB  . ALA A 1 309 ? -19.49659 5.56984  -14.76284 1.000 22.80399  ? 309 ALA A CB  1 
ATOM   2339 N N   . GLN A 1 310 ? -18.13850 8.41742  -15.50017 1.000 20.41919  ? 310 GLN A N   1 
ATOM   2340 C CA  . GLN A 1 310 ? -16.93004 9.22360  -15.65003 1.000 21.98919  ? 310 GLN A CA  1 
ATOM   2341 C C   . GLN A 1 310 ? -16.97393 10.51849 -14.82733 1.000 23.13919  ? 310 GLN A C   1 
ATOM   2342 O O   . GLN A 1 310 ? -15.92104 11.11517 -14.55094 1.000 21.58919  ? 310 GLN A O   1 
ATOM   2343 C CB  . GLN A 1 310 ? -16.74545 9.52396  -17.14121 1.000 31.75919  ? 310 GLN A CB  1 
ATOM   2344 C CG  . GLN A 1 310 ? -15.44411 10.17893 -17.57704 1.000 45.76919  ? 310 GLN A CG  1 
ATOM   2345 C CD  . GLN A 1 310 ? -15.44694 10.52404 -19.06818 1.000 52.37919  ? 310 GLN A CD  1 
ATOM   2346 O OE1 . GLN A 1 310 ? -16.41879 10.24473 -19.78130 1.000 57.63919  ? 310 GLN A OE1 1 
ATOM   2347 N NE2 . GLN A 1 310 ? -14.36053 11.13742 -19.54214 1.000 55.67919  ? 310 GLN A NE2 1 
ATOM   2348 N N   . TYR A 1 311 ? -18.15720 10.97624 -14.42613 1.000 21.18963  ? 311 TYR A N   1 
ATOM   2349 C CA  . TYR A 1 311 ? -18.29235 12.29466 -13.82487 1.000 19.14963  ? 311 TYR A CA  1 
ATOM   2350 C C   . TYR A 1 311 ? -18.86921 12.27899 -12.41907 1.000 19.57963  ? 311 TYR A C   1 
ATOM   2351 O O   . TYR A 1 311 ? -18.63441 13.22729 -11.66191 1.000 22.97963  ? 311 TYR A O   1 
ATOM   2352 C CB  . TYR A 1 311 ? -19.17508 13.18855 -14.71508 1.000 19.69963  ? 311 TYR A CB  1 
ATOM   2353 C CG  . TYR A 1 311 ? -18.53977 13.51104 -16.05128 1.000 22.42963  ? 311 TYR A CG  1 
ATOM   2354 C CD1 . TYR A 1 311 ? -17.51428 14.43649 -16.13526 1.000 27.93963  ? 311 TYR A CD1 1 
ATOM   2355 C CD2 . TYR A 1 311 ? -18.95646 12.88779 -17.22281 1.000 23.57963  ? 311 TYR A CD2 1 
ATOM   2356 C CE1 . TYR A 1 311 ? -16.91914 14.74270 -17.34670 1.000 27.73963  ? 311 TYR A CE1 1 
ATOM   2357 C CE2 . TYR A 1 311 ? -18.36294 13.18369 -18.43344 1.000 24.84963  ? 311 TYR A CE2 1 
ATOM   2358 C CZ  . TYR A 1 311 ? -17.34459 14.11419 -18.48484 1.000 28.15963  ? 311 TYR A CZ  1 
ATOM   2359 O OH  . TYR A 1 311 ? -16.73532 14.43348 -19.68006 1.000 35.59963  ? 311 TYR A OH  1 
ATOM   2360 N N   . HIS A 1 312 ? -19.60348 11.24177 -12.05310 1.000 21.36868  ? 312 HIS A N   1 
ATOM   2361 C CA  . HIS A 1 312 ? -20.36115 11.22689 -10.81032 1.000 20.24868  ? 312 HIS A CA  1 
ATOM   2362 C C   . HIS A 1 312 ? -19.43668 11.15908 -9.60113  1.000 25.22868  ? 312 HIS A C   1 
ATOM   2363 O O   . HIS A 1 312 ? -18.57851 10.28147 -9.51155  1.000 24.09868  ? 312 HIS A O   1 
ATOM   2364 C CB  . HIS A 1 312 ? -21.29049 10.02825 -10.84095 1.000 18.94868  ? 312 HIS A CB  1 
ATOM   2365 C CG  . HIS A 1 312 ? -22.00929 9.74970  -9.55591  1.000 20.01868  ? 312 HIS A CG  1 
ATOM   2366 N ND1 . HIS A 1 312 ? -22.79820 10.68403 -8.91483  1.000 19.76868  ? 312 HIS A ND1 1 
ATOM   2367 C CD2 . HIS A 1 312 ? -22.10494 8.61270  -8.82751  1.000 19.55868  ? 312 HIS A CD2 1 
ATOM   2368 C CE1 . HIS A 1 312 ? -23.33849 10.13250 -7.84023  1.000 20.18868  ? 312 HIS A CE1 1 
ATOM   2369 N NE2 . HIS A 1 312 ? -22.92689 8.88014  -7.76119  1.000 18.10868  ? 312 HIS A NE2 1 
ATOM   2370 N N   . ASP A 1 313 ? -19.60129 12.10296 -8.67695  1.000 23.46771  ? 313 ASP A N   1 
ATOM   2371 C CA  . ASP A 1 313 ? -18.84384 12.12337 -7.42754  1.000 24.58771  ? 313 ASP A CA  1 
ATOM   2372 C C   . ASP A 1 313 ? -19.85911 12.44978 -6.34402  1.000 22.18771  ? 313 ASP A C   1 
ATOM   2373 O O   . ASP A 1 313 ? -20.27849 13.61103 -6.20979  1.000 18.48771  ? 313 ASP A O   1 
ATOM   2374 C CB  . ASP A 1 313 ? -17.70935 13.14418 -7.47726  1.000 24.60771  ? 313 ASP A CB  1 
ATOM   2375 C CG  . ASP A 1 313 ? -16.88359 13.20274 -6.17933  1.000 25.04771  ? 313 ASP A CG  1 
ATOM   2376 O OD1 . ASP A 1 313 ? -17.17846 12.49312 -5.18154  1.000 22.47771  ? 313 ASP A OD1 1 
ATOM   2377 O OD2 . ASP A 1 313 ? -15.91600 13.98424 -6.17565  1.000 30.32771  ? 313 ASP A OD2 1 
ATOM   2378 N N   . PRO A 1 314 ? -20.28240 11.45698 -5.55556  1.000 24.34437  ? 314 PRO A N   1 
ATOM   2379 C CA  . PRO A 1 314 ? -21.38047 11.68746 -4.60305  1.000 24.32437  ? 314 PRO A CA  1 
ATOM   2380 C C   . PRO A 1 314 ? -21.00098 12.58968 -3.44468  1.000 24.91437  ? 314 PRO A C   1 
ATOM   2381 O O   . PRO A 1 314 ? -21.89465 13.02623 -2.71068  1.000 27.39437  ? 314 PRO A O   1 
ATOM   2382 C CB  . PRO A 1 314 ? -21.73549 10.27147 -4.12122  1.000 28.62437  ? 314 PRO A CB  1 
ATOM   2383 C CG  . PRO A 1 314 ? -20.50362 9.45354  -4.35474  1.000 24.82437  ? 314 PRO A CG  1 
ATOM   2384 C CD  . PRO A 1 314 ? -19.81364 10.05523 -5.55852  1.000 26.35437  ? 314 PRO A CD  1 
ATOM   2385 N N   . ASP A 1 315 ? -19.72149 12.90623 -3.27884  1.000 25.62504  ? 315 ASP A N   1 
ATOM   2386 C CA  . ASP A 1 315 ? -19.27826 13.90559 -2.31977  1.000 28.29504  ? 315 ASP A CA  1 
ATOM   2387 C C   . ASP A 1 315 ? -19.20468 15.30113 -2.91864  1.000 23.29504  ? 315 ASP A C   1 
ATOM   2388 O O   . ASP A 1 315 ? -18.92295 16.25969 -2.19073  1.000 22.68504  ? 315 ASP A O   1 
ATOM   2389 C CB  . ASP A 1 315 ? -17.90912 13.51123 -1.75387  1.000 33.81504  ? 315 ASP A CB  1 
ATOM   2390 C CG  . ASP A 1 315 ? -17.95161 12.18133 -1.01276  1.000 39.43504  ? 315 ASP A CG  1 
ATOM   2391 O OD1 . ASP A 1 315 ? -18.94206 11.93957 -0.28605  1.000 48.74504  ? 315 ASP A OD1 1 
ATOM   2392 O OD2 . ASP A 1 315 ? -17.00744 11.37276 -1.17032  1.000 47.38504  ? 315 ASP A OD2 1 
ATOM   2393 N N   . ASP A 1 316 ? -19.45438 15.44742 -4.21484  1.000 20.89530  ? 316 ASP A N   1 
ATOM   2394 C CA  . ASP A 1 316 ? -19.37339 16.74571 -4.86801  1.000 21.97530  ? 316 ASP A CA  1 
ATOM   2395 C C   . ASP A 1 316 ? -20.68156 17.05098 -5.60101  1.000 17.79530  ? 316 ASP A C   1 
ATOM   2396 O O   . ASP A 1 316 ? -20.68057 17.61766 -6.69877  1.000 16.95530  ? 316 ASP A O   1 
ATOM   2397 C CB  . ASP A 1 316 ? -18.16842 16.80105 -5.81172  1.000 24.54530  ? 316 ASP A CB  1 
ATOM   2398 C CG  . ASP A 1 316 ? -17.81695 18.22738 -6.25595  1.000 31.65530  ? 316 ASP A CG  1 
ATOM   2399 O OD1 . ASP A 1 316 ? -18.22370 19.19528 -5.57500  1.000 37.15530  ? 316 ASP A OD1 1 
ATOM   2400 O OD2 . ASP A 1 316 ? -17.16774 18.37839 -7.31352  1.000 41.69530  ? 316 ASP A OD2 1 
ATOM   2401 N N   . GLU A 1 317 ? -21.81879 16.65268 -5.00900  1.000 15.95310  ? 317 GLU A N   1 
ATOM   2402 C CA  . GLU A 1 317 ? -23.15854 16.90061 -5.55639  1.000 13.85310  ? 317 GLU A CA  1 
ATOM   2403 C C   . GLU A 1 317 ? -24.03079 17.45369 -4.42823  1.000 13.82310  ? 317 GLU A C   1 
ATOM   2404 O O   . GLU A 1 317 ? -24.89508 16.75350 -3.88706  1.000 15.03310  ? 317 GLU A O   1 
ATOM   2405 C CB  . GLU A 1 317 ? -23.73709 15.62016 -6.17837  1.000 13.71310  ? 317 GLU A CB  1 
ATOM   2406 C CG  . GLU A 1 317 ? -22.91315 15.18290 -7.41542  1.000 15.20310  ? 317 GLU A CG  1 
ATOM   2407 C CD  . GLU A 1 317 ? -23.10526 13.74215 -7.87451  1.000 16.36310  ? 317 GLU A CD  1 
ATOM   2408 O OE1 . GLU A 1 317 ? -23.85228 12.98874 -7.22070  1.000 18.47310  ? 317 GLU A OE1 1 
ATOM   2409 O OE2 . GLU A 1 317 ? -22.49227 13.36679 -8.91264  1.000 18.32310  ? 317 GLU A OE2 1 
ATOM   2410 N N   . PRO A 1 318 ? -23.81093 18.70904 -4.03903  1.000 14.89947  ? 318 PRO A N   1 
ATOM   2411 C CA  . PRO A 1 318 ? -24.41878 19.23079 -2.80844  1.000 17.52947  ? 318 PRO A CA  1 
ATOM   2412 C C   . PRO A 1 318 ? -25.89019 19.58109 -2.96923  1.000 19.65947  ? 318 PRO A C   1 
ATOM   2413 O O   . PRO A 1 318 ? -26.40036 19.80549 -4.07363  1.000 17.07947  ? 318 PRO A O   1 
ATOM   2414 C CB  . PRO A 1 318 ? -23.60027 20.49286 -2.52698  1.000 18.83947  ? 318 PRO A CB  1 
ATOM   2415 C CG  . PRO A 1 318 ? -23.21711 20.98633 -3.88583  1.000 19.58947  ? 318 PRO A CG  1 
ATOM   2416 C CD  . PRO A 1 318 ? -22.95549 19.71882 -4.69668  1.000 16.07947  ? 318 PRO A CD  1 
ATOM   2417 N N   . VAL A 1 319 ? -26.55711 19.64666 -1.82206  1.000 17.96165  ? 319 VAL A N   1 
ATOM   2418 C CA  . VAL A 1 319 ? -27.94600 20.04510 -1.73963  1.000 17.35165  ? 319 VAL A CA  1 
ATOM   2419 C C   . VAL A 1 319 ? -28.01947 21.48323 -1.23265  1.000 14.87165  ? 319 VAL A C   1 
ATOM   2420 O O   . VAL A 1 319 ? -27.02883 22.06401 -0.80066  1.000 18.80165  ? 319 VAL A O   1 
ATOM   2421 C CB  . VAL A 1 319 ? -28.76121 19.08573 -0.83413  1.000 21.57165  ? 319 VAL A CB  1 
ATOM   2422 C CG1 . VAL A 1 319 ? -28.82696 17.68366 -1.45596  1.000 22.98165  ? 319 VAL A CG1 1 
ATOM   2423 C CG2 . VAL A 1 319 ? -28.16559 19.02905 0.58348   1.000 20.36165  ? 319 VAL A CG2 1 
ATOM   2424 N N   . ALA A 1 320 ? -29.21138 22.06573 -1.27948  1.000 13.57977  ? 320 ALA A N   1 
ATOM   2425 C CA  . ALA A 1 320 ? -29.43168 23.44738 -0.87881  1.000 14.40977  ? 320 ALA A CA  1 
ATOM   2426 C C   . ALA A 1 320 ? -29.87203 23.54501 0.58338   1.000 16.14977  ? 320 ALA A C   1 
ATOM   2427 O O   . ALA A 1 320 ? -30.35692 22.58116 1.17092   1.000 16.43977  ? 320 ALA A O   1 
ATOM   2428 C CB  . ALA A 1 320 ? -30.49685 24.09352 -1.77161  1.000 14.64977  ? 320 ALA A CB  1 
ATOM   2429 N N   . ASP A 1 321 ? -29.72005 24.74151 1.15514   1.000 16.69089  ? 321 ASP A N   1 
ATOM   2430 C CA  . ASP A 1 321 ? -30.48350 25.09354 2.34812   1.000 18.86089  ? 321 ASP A CA  1 
ATOM   2431 C C   . ASP A 1 321 ? -31.97703 24.99655 2.04318   1.000 17.87089  ? 321 ASP A C   1 
ATOM   2432 O O   . ASP A 1 321 ? -32.39208 25.24787 0.90942   1.000 15.18089  ? 321 ASP A O   1 
ATOM   2433 C CB  . ASP A 1 321 ? -30.17526 26.51977 2.80059   1.000 22.18089  ? 321 ASP A CB  1 
ATOM   2434 C CG  . ASP A 1 321 ? -28.88290 26.62509 3.55254   1.000 28.15089  ? 321 ASP A CG  1 
ATOM   2435 O OD1 . ASP A 1 321 ? -28.18866 25.60025 3.67431   1.000 25.96089  ? 321 ASP A OD1 1 
ATOM   2436 O OD2 . ASP A 1 321 ? -28.56691 27.73585 4.02216   1.000 36.08089  ? 321 ASP A OD2 1 
ATOM   2437 N N   . PRO A 1 322 ? -32.80500 24.66078 3.03072   1.000 18.29749  ? 322 PRO A N   1 
ATOM   2438 C CA  . PRO A 1 322 ? -34.25866 24.71057 2.80753   1.000 22.71749  ? 322 PRO A CA  1 
ATOM   2439 C C   . PRO A 1 322 ? -34.69894 26.13514 2.49130   1.000 18.67749  ? 322 PRO A C   1 
ATOM   2440 O O   . PRO A 1 322 ? -34.08565 27.10604 2.93379   1.000 19.47749  ? 322 PRO A O   1 
ATOM   2441 C CB  . PRO A 1 322 ? -34.84613 24.19900 4.13066   1.000 24.62749  ? 322 PRO A CB  1 
ATOM   2442 C CG  . PRO A 1 322 ? -33.76356 24.41507 5.14750   1.000 25.19749  ? 322 PRO A CG  1 
ATOM   2443 C CD  . PRO A 1 322 ? -32.46297 24.27164 4.41712   1.000 22.14749  ? 322 PRO A CD  1 
ATOM   2444 N N   . TYR A 1 323 ? -35.70141 26.25118 1.63414   1.000 17.34117  ? 323 TYR A N   1 
ATOM   2445 C CA  . TYR A 1 323 ? -36.14228 27.53387 1.10004   1.000 19.31117  ? 323 TYR A CA  1 
ATOM   2446 C C   . TYR A 1 323 ? -37.54833 27.81469 1.61367   1.000 19.36117  ? 323 TYR A C   1 
ATOM   2447 O O   . TYR A 1 323 ? -38.48243 27.05947 1.31697   1.000 18.77117  ? 323 TYR A O   1 
ATOM   2448 C CB  . TYR A 1 323 ? -36.10473 27.51224 -0.42964  1.000 19.15117  ? 323 TYR A CB  1 
ATOM   2449 C CG  . TYR A 1 323 ? -36.58723 28.77746 -1.10339  1.000 19.37117  ? 323 TYR A CG  1 
ATOM   2450 C CD1 . TYR A 1 323 ? -36.03387 30.02032 -0.79535  1.000 18.93117  ? 323 TYR A CD1 1 
ATOM   2451 C CD2 . TYR A 1 323 ? -37.57109 28.72536 -2.07078  1.000 17.16117  ? 323 TYR A CD2 1 
ATOM   2452 C CE1 . TYR A 1 323 ? -36.47902 31.18633 -1.43075  1.000 17.81117  ? 323 TYR A CE1 1 
ATOM   2453 C CE2 . TYR A 1 323 ? -38.03166 29.88174 -2.69711  1.000 20.53117  ? 323 TYR A CE2 1 
ATOM   2454 C CZ  . TYR A 1 323 ? -37.47287 31.10436 -2.37902  1.000 20.78117  ? 323 TYR A CZ  1 
ATOM   2455 O OH  . TYR A 1 323 ? -37.93841 32.23025 -3.01728  1.000 25.73117  ? 323 TYR A OH  1 
ATOM   2456 N N   . ASP A 1 324 ? -37.69969 28.88950 2.38609   1.000 19.07449  ? 324 ASP A N   1 
ATOM   2457 C CA  . ASP A 1 324 ? -38.99270 29.21550 2.98986   1.000 17.40449  ? 324 ASP A CA  1 
ATOM   2458 C C   . ASP A 1 324 ? -39.85437 29.93441 1.95806   1.000 16.18449  ? 324 ASP A C   1 
ATOM   2459 O O   . ASP A 1 324 ? -39.61033 31.10354 1.63898   1.000 14.56449  ? 324 ASP A O   1 
ATOM   2460 C CB  . ASP A 1 324 ? -38.81536 30.07364 4.24028   1.000 21.32449  ? 324 ASP A CB  1 
ATOM   2461 C CG  . ASP A 1 324 ? -40.14589 30.38171 4.94834   1.000 24.02449  ? 324 ASP A CG  1 
ATOM   2462 O OD1 . ASP A 1 324 ? -41.22611 29.96866 4.48503   1.000 22.79449  ? 324 ASP A OD1 1 
ATOM   2463 O OD2 . ASP A 1 324 ? -40.11771 31.03445 6.00059   1.000 30.64449  ? 324 ASP A OD2 1 
ATOM   2464 N N   . GLN A 1 325 ? -40.90246 29.25989 1.49059   1.000 15.42761  ? 325 GLN A N   1 
ATOM   2465 C CA  . GLN A 1 325 ? -41.85911 29.85126 0.56743   1.000 19.37761  ? 325 GLN A CA  1 
ATOM   2466 C C   . GLN A 1 325 ? -43.15430 30.26993 1.24839   1.000 18.76761  ? 325 GLN A C   1 
ATOM   2467 O O   . GLN A 1 325 ? -44.16031 30.47422 0.55978   1.000 16.03761  ? 325 GLN A O   1 
ATOM   2468 C CB  . GLN A 1 325 ? -42.17403 28.87909 -0.56826  1.000 22.92761  ? 325 GLN A CB  1 
ATOM   2469 C CG  . GLN A 1 325 ? -40.94881 28.38803 -1.26383  1.000 26.50761  ? 325 GLN A CG  1 
ATOM   2470 C CD  . GLN A 1 325 ? -41.23992 27.77441 -2.61514  1.000 28.94761  ? 325 GLN A CD  1 
ATOM   2471 O OE1 . GLN A 1 325 ? -41.84631 28.40598 -3.48252  1.000 30.90761  ? 325 GLN A OE1 1 
ATOM   2472 N NE2 . GLN A 1 325 ? -40.81280 26.53292 -2.79956  1.000 32.75761  ? 325 GLN A NE2 1 
ATOM   2473 N N   . SER A 1 326 ? -43.15507 30.41737 2.57960   1.000 20.08926  ? 326 SER A N   1 
ATOM   2474 C CA  . SER A 1 326 ? -44.40178 30.76221 3.26160   1.000 22.07926  ? 326 SER A CA  1 
ATOM   2475 C C   . SER A 1 326 ? -44.91343 32.15392 2.89463   1.000 19.43926  ? 326 SER A C   1 
ATOM   2476 O O   . SER A 1 326 ? -46.10574 32.41542 3.07815   1.000 19.79926  ? 326 SER A O   1 
ATOM   2477 C CB  . SER A 1 326 ? -44.24951 30.65170 4.77808   1.000 20.72926  ? 326 SER A CB  1 
ATOM   2478 O OG  . SER A 1 326 ? -43.20087 31.47802 5.24678   1.000 19.34926  ? 326 SER A OG  1 
ATOM   2479 N N   . PHE A 1 327 ? -44.05841 33.02964 2.34303   1.000 15.98816  ? 327 PHE A N   1 
ATOM   2480 C CA  . PHE A 1 327 ? -44.52736 34.31818 1.84175   1.000 15.78816  ? 327 PHE A CA  1 
ATOM   2481 C C   . PHE A 1 327 ? -45.58147 34.17057 0.75689   1.000 16.62816  ? 327 PHE A C   1 
ATOM   2482 O O   . PHE A 1 327 ? -46.35916 35.10494 0.55127   1.000 15.00816  ? 327 PHE A O   1 
ATOM   2483 C CB  . PHE A 1 327 ? -43.36079 35.16076 1.28551   1.000 16.20816  ? 327 PHE A CB  1 
ATOM   2484 C CG  . PHE A 1 327 ? -42.77250 34.61973 0.00086   1.000 15.92816  ? 327 PHE A CG  1 
ATOM   2485 C CD1 . PHE A 1 327 ? -41.75270 33.67829 0.04147   1.000 16.23816  ? 327 PHE A CD1 1 
ATOM   2486 C CD2 . PHE A 1 327 ? -43.23764 35.05662 -1.24655  1.000 17.53816  ? 327 PHE A CD2 1 
ATOM   2487 C CE1 . PHE A 1 327 ? -41.20278 33.18106 -1.12846  1.000 20.24816  ? 327 PHE A CE1 1 
ATOM   2488 C CE2 . PHE A 1 327 ? -42.70974 34.55104 -2.42092  1.000 19.09816  ? 327 PHE A CE2 1 
ATOM   2489 C CZ  . PHE A 1 327 ? -41.68968 33.61172 -2.36662  1.000 18.44816  ? 327 PHE A CZ  1 
ATOM   2490 N N   . GLU A 1 328 ? -45.61060 33.03496 0.04624   1.000 16.69889  ? 328 GLU A N   1 
ATOM   2491 C CA  . GLU A 1 328 ? -46.51774 32.89972 -1.09386  1.000 21.01889  ? 328 GLU A CA  1 
ATOM   2492 C C   . GLU A 1 328 ? -47.97787 32.96364 -0.67505  1.000 20.61889  ? 328 GLU A C   1 
ATOM   2493 O O   . GLU A 1 328 ? -48.82442 33.40562 -1.45768  1.000 20.65889  ? 328 GLU A O   1 
ATOM   2494 C CB  . GLU A 1 328 ? -46.26041 31.59521 -1.85770  1.000 23.28889  ? 328 GLU A CB  1 
ATOM   2495 C CG  . GLU A 1 328 ? -44.96445 31.55748 -2.67211  1.000 26.23889  ? 328 GLU A CG  1 
ATOM   2496 C CD  . GLU A 1 328 ? -44.99887 32.41737 -3.93768  1.000 26.77889  ? 328 GLU A CD  1 
ATOM   2497 O OE1 . GLU A 1 328 ? -46.00551 33.09778 -4.21638  1.000 26.32889  ? 328 GLU A OE1 1 
ATOM   2498 O OE2 . GLU A 1 328 ? -43.99080 32.41236 -4.66719  1.000 29.75889  ? 328 GLU A OE2 1 
ATOM   2499 N N   . SER A 1 329 ? -48.28558 32.56813 0.55588   1.000 20.11994  ? 329 SER A N   1 
ATOM   2500 C CA  . SER A 1 329 ? -49.64648 32.62634 1.05133   1.000 25.80994  ? 329 SER A CA  1 
ATOM   2501 C C   . SER A 1 329 ? -49.93472 33.90687 1.82210   1.000 22.75994  ? 329 SER A C   1 
ATOM   2502 O O   . SER A 1 329 ? -50.98148 33.99683 2.47040   1.000 22.54994  ? 329 SER A O   1 
ATOM   2503 C CB  . SER A 1 329 ? -49.93952 31.39731 1.92087   1.000 23.38994  ? 329 SER A CB  1 
ATOM   2504 O OG  . SER A 1 329 ? -49.09415 31.38278 3.04460   1.000 33.72994  ? 329 SER A OG  1 
ATOM   2505 N N   . ARG A 1 330 ? -49.05413 34.90333 1.75519   1.000 17.88814  ? 330 ARG A N   1 
ATOM   2506 C CA  . ARG A 1 330 ? -49.31764 36.16446 2.43057   1.000 18.76814  ? 330 ARG A CA  1 
ATOM   2507 C C   . ARG A 1 330 ? -50.07039 37.10786 1.49639   1.000 20.30814  ? 330 ARG A C   1 
ATOM   2508 O O   . ARG A 1 330 ? -49.86031 37.10953 0.28061   1.000 23.37814  ? 330 ARG A O   1 
ATOM   2509 C CB  . ARG A 1 330 ? -48.02264 36.82773 2.92572   1.000 16.57814  ? 330 ARG A CB  1 
ATOM   2510 C CG  . ARG A 1 330 ? -47.19951 35.95730 3.90141   1.000 15.96814  ? 330 ARG A CG  1 
ATOM   2511 C CD  . ARG A 1 330 ? -45.91410 36.64839 4.35634   1.000 16.63814  ? 330 ARG A CD  1 
ATOM   2512 N NE  . ARG A 1 330 ? -46.18215 37.80448 5.20455   1.000 14.16814  ? 330 ARG A NE  1 
ATOM   2513 C CZ  . ARG A 1 330 ? -45.25503 38.60171 5.71753   1.000 15.25814  ? 330 ARG A CZ  1 
ATOM   2514 N NH1 . ARG A 1 330 ? -43.96789 38.46041 5.41284   1.000 14.65814  ? 330 ARG A NH1 1 
ATOM   2515 N NH2 . ARG A 1 330 ? -45.62671 39.57344 6.54805   1.000 13.46814  ? 330 ARG A NH2 1 
ATOM   2516 N N   . ASP A 1 331 ? -50.93445 37.93165 2.08177   1.000 20.99136  ? 331 ASP A N   1 
ATOM   2517 C CA  . ASP A 1 331 ? -51.79136 38.85085 1.32790   1.000 24.86136  ? 331 ASP A CA  1 
ATOM   2518 C C   . ASP A 1 331 ? -51.48565 40.27029 1.79480   1.000 19.21136  ? 331 ASP A C   1 
ATOM   2519 O O   . ASP A 1 331 ? -51.98905 40.70971 2.83171   1.000 20.04136  ? 331 ASP A O   1 
ATOM   2520 C CB  . ASP A 1 331 ? -53.25402 38.48169 1.53891   1.000 34.79136  ? 331 ASP A CB  1 
ATOM   2521 C CG  . ASP A 1 331 ? -54.16285 39.07464 0.49811   1.000 43.02136  ? 331 ASP A CG  1 
ATOM   2522 O OD1 . ASP A 1 331 ? -53.66556 39.78154 -0.40391  1.000 54.44136  ? 331 ASP A OD1 1 
ATOM   2523 O OD2 . ASP A 1 331 ? -55.38257 38.82557 0.58397   1.000 58.36136  ? 331 ASP A OD2 1 
ATOM   2524 N N   . LEU A 1 332 ? -50.65065 40.99121 1.04915   1.000 18.40985  ? 332 LEU A N   1 
ATOM   2525 C CA  . LEU A 1 332 ? -50.07370 42.23495 1.53858   1.000 18.19985  ? 332 LEU A CA  1 
ATOM   2526 C C   . LEU A 1 332 ? -50.33244 43.37552 0.56687   1.000 16.04985  ? 332 LEU A C   1 
ATOM   2527 O O   . LEU A 1 332 ? -50.58836 43.15833 -0.61912  1.000 20.15985  ? 332 LEU A O   1 
ATOM   2528 C CB  . LEU A 1 332 ? -48.55492 42.09359 1.75880   1.000 17.95985  ? 332 LEU A CB  1 
ATOM   2529 C CG  . LEU A 1 332 ? -48.13021 40.88896 2.61402   1.000 18.50985  ? 332 LEU A CG  1 
ATOM   2530 C CD1 . LEU A 1 332 ? -46.61593 40.75647 2.67750   1.000 18.97985  ? 332 LEU A CD1 1 
ATOM   2531 C CD2 . LEU A 1 332 ? -48.71229 40.99585 4.02518   1.000 18.64985  ? 332 LEU A CD2 1 
ATOM   2532 N N   . LEU A 1 333 ? -50.21530 44.59705 1.08936   1.000 14.53009  ? 333 LEU A N   1 
ATOM   2533 C CA  . LEU A 1 333 ? -50.29041 45.81583 0.29692   1.000 17.71009  ? 333 LEU A CA  1 
ATOM   2534 C C   . LEU A 1 333 ? -49.08143 45.93384 -0.63182  1.000 21.64009  ? 333 LEU A C   1 
ATOM   2535 O O   . LEU A 1 333 ? -48.03251 45.34099 -0.38013  1.000 15.41009  ? 333 LEU A O   1 
ATOM   2536 C CB  . LEU A 1 333 ? -50.32410 47.02912 1.20921   1.000 19.38009  ? 333 LEU A CB  1 
ATOM   2537 C CG  . LEU A 1 333 ? -51.40644 47.00220 2.27850   1.000 20.61009  ? 333 LEU A CG  1 
ATOM   2538 C CD1 . LEU A 1 333 ? -51.22798 48.23074 3.15118   1.000 21.79009  ? 333 LEU A CD1 1 
ATOM   2539 C CD2 . LEU A 1 333 ? -52.77366 46.96938 1.60123   1.000 22.83009  ? 333 LEU A CD2 1 
ATOM   2540 N N   . ILE A 1 334 ? -49.24327 46.73552 -1.69951  1.000 19.93104  ? 334 ILE A N   1 
ATOM   2541 C CA  . ILE A 1 334 ? -48.14443 47.03749 -2.62381  1.000 19.61104  ? 334 ILE A CA  1 
ATOM   2542 C C   . ILE A 1 334 ? -46.91793 47.50947 -1.86159  1.000 19.38104  ? 334 ILE A C   1 
ATOM   2543 O O   . ILE A 1 334 ? -45.79895 47.01288 -2.06981  1.000 19.32104  ? 334 ILE A O   1 
ATOM   2544 C CB  . ILE A 1 334 ? -48.56890 48.10727 -3.64938  1.000 26.78104  ? 334 ILE A CB  1 
ATOM   2545 C CG1 . ILE A 1 334 ? -49.45622 47.52935 -4.73261  1.000 31.82104  ? 334 ILE A CG1 1 
ATOM   2546 C CG2 . ILE A 1 334 ? -47.34065 48.73929 -4.32090  1.000 27.29104  ? 334 ILE A CG2 1 
ATOM   2547 C CD1 . ILE A 1 334 ? -49.87094 48.57590 -5.77568  1.000 35.60104  ? 334 ILE A CD1 1 
ATOM   2548 N N   . ASP A 1 335 ? -47.11650 48.46564 -0.94755  1.000 18.70311  ? 335 ASP A N   1 
ATOM   2549 C CA  . ASP A 1 335 ? -45.98348 49.05549 -0.25164  1.000 20.20311  ? 335 ASP A CA  1 
ATOM   2550 C C   . ASP A 1 335 ? -45.36711 48.10393 0.75627   1.000 16.99311  ? 335 ASP A C   1 
ATOM   2551 O O   . ASP A 1 335 ? -44.19871 48.29415 1.10998   1.000 18.30311  ? 335 ASP A O   1 
ATOM   2552 C CB  . ASP A 1 335 ? -46.39829 50.36884 0.41436   1.000 26.79311  ? 335 ASP A CB  1 
ATOM   2553 C CG  . ASP A 1 335 ? -46.52899 51.50857 -0.59602  1.000 40.27311  ? 335 ASP A CG  1 
ATOM   2554 O OD1 . ASP A 1 335 ? -45.51283 51.86670 -1.24554  1.000 38.86311  ? 335 ASP A OD1 1 
ATOM   2555 O OD2 . ASP A 1 335 ? -47.65623 52.01968 -0.77198  1.000 59.47311  ? 335 ASP A OD2 1 
ATOM   2556 N N   . GLU A 1 336 ? -46.12116 47.08454 1.20681   1.000 16.40882  ? 336 GLU A N   1 
ATOM   2557 C CA  . GLU A 1 336 ? -45.57542 46.03863 2.07151   1.000 16.46882  ? 336 GLU A CA  1 
ATOM   2558 C C   . GLU A 1 336 ? -44.68507 45.07147 1.28950   1.000 16.00882  ? 336 GLU A C   1 
ATOM   2559 O O   . GLU A 1 336 ? -43.58370 44.74606 1.74416   1.000 15.33882  ? 336 GLU A O   1 
ATOM   2560 C CB  . GLU A 1 336 ? -46.70591 45.28369 2.78134   1.000 16.39882  ? 336 GLU A CB  1 
ATOM   2561 C CG  . GLU A 1 336 ? -47.34703 46.09904 3.92871   1.000 18.11882  ? 336 GLU A CG  1 
ATOM   2562 C CD  . GLU A 1 336 ? -48.52146 45.38762 4.62280   1.000 17.76882  ? 336 GLU A CD  1 
ATOM   2563 O OE1 . GLU A 1 336 ? -49.28607 44.65962 3.94218   1.000 18.18882  ? 336 GLU A OE1 1 
ATOM   2564 O OE2 . GLU A 1 336 ? -48.66884 45.57374 5.85813   1.000 21.08882  ? 336 GLU A OE2 1 
ATOM   2565 N N   . TRP A 1 337 ? -45.13203 44.61724 0.11239   1.000 15.55238  ? 337 TRP A N   1 
ATOM   2566 C CA  . TRP A 1 337 ? -44.24500 43.85208 -0.76958  1.000 15.79238  ? 337 TRP A CA  1 
ATOM   2567 C C   . TRP A 1 337 ? -43.02065 44.66705 -1.15914  1.000 15.61238  ? 337 TRP A C   1 
ATOM   2568 O O   . TRP A 1 337 ? -41.90518 44.13615 -1.22997  1.000 14.46238  ? 337 TRP A O   1 
ATOM   2569 C CB  . TRP A 1 337 ? -44.98314 43.40244 -2.02997  1.000 12.76238  ? 337 TRP A CB  1 
ATOM   2570 C CG  . TRP A 1 337 ? -45.97093 42.33052 -1.79391  1.000 14.18238  ? 337 TRP A CG  1 
ATOM   2571 C CD1 . TRP A 1 337 ? -47.31745 42.40093 -1.99366  1.000 14.13238  ? 337 TRP A CD1 1 
ATOM   2572 C CD2 . TRP A 1 337 ? -45.70527 41.01667 -1.28757  1.000 14.23238  ? 337 TRP A CD2 1 
ATOM   2573 N NE1 . TRP A 1 337 ? -47.90438 41.20739 -1.66502  1.000 14.72238  ? 337 TRP A NE1 1 
ATOM   2574 C CE2 . TRP A 1 337 ? -46.94137 40.33875 -1.22651  1.000 15.56238  ? 337 TRP A CE2 1 
ATOM   2575 C CE3 . TRP A 1 337 ? -44.54779 40.34707 -0.88526  1.000 14.03238  ? 337 TRP A CE3 1 
ATOM   2576 C CZ2 . TRP A 1 337 ? -47.05515 39.02364 -0.76865  1.000 15.44238  ? 337 TRP A CZ2 1 
ATOM   2577 C CZ3 . TRP A 1 337 ? -44.66097 39.03706 -0.42856  1.000 14.97238  ? 337 TRP A CZ3 1 
ATOM   2578 C CH2 . TRP A 1 337 ? -45.90428 38.38971 -0.38171  1.000 16.49238  ? 337 TRP A CH2 1 
ATOM   2579 N N   . LYS A 1 338 ? -43.21519 45.96152 -1.41462  1.000 16.21574  ? 338 LYS A N   1 
ATOM   2580 C CA  . LYS A 1 338 ? -42.10152 46.83426 -1.77091  1.000 16.65574  ? 338 LYS A CA  1 
ATOM   2581 C C   . LYS A 1 338 ? -41.12380 46.98927 -0.61004  1.000 16.45574  ? 338 LYS A C   1 
ATOM   2582 O O   . LYS A 1 338 ? -39.90427 46.94265 -0.80982  1.000 14.64574  ? 338 LYS A O   1 
ATOM   2583 C CB  . LYS A 1 338 ? -42.63852 48.19811 -2.21790  1.000 20.13574  ? 338 LYS A CB  1 
ATOM   2584 C CG  . LYS A 1 338 ? -41.55019 49.19863 -2.60632  1.000 25.03574  ? 338 LYS A CG  1 
ATOM   2585 C CD  . LYS A 1 338 ? -42.13207 50.34833 -3.43717  1.000 31.42574  ? 338 LYS A CD  1 
ATOM   2586 C CE  . LYS A 1 338 ? -42.05225 51.65947 -2.67609  1.000 38.74574  ? 338 LYS A CE  1 
ATOM   2587 N NZ  . LYS A 1 338 ? -42.08044 52.83156 -3.60138  1.000 46.13574  ? 338 LYS A NZ  1 
ATOM   2588 N N   . SER A 1 339 ? -41.63977 47.17767 0.61026   1.000 16.77748  ? 339 SER A N   1 
ATOM   2589 C CA  . SER A 1 339 ? -40.77772 47.25420 1.78818   1.000 17.11748  ? 339 SER A CA  1 
ATOM   2590 C C   . SER A 1 339 ? -40.02743 45.94028 2.02811   1.000 13.67748  ? 339 SER A C   1 
ATOM   2591 O O   . SER A 1 339 ? -38.85173 45.95223 2.41571   1.000 12.32748  ? 339 SER A O   1 
ATOM   2592 C CB  . SER A 1 339 ? -41.61772 47.62293 3.01565   1.000 17.64748  ? 339 SER A CB  1 
ATOM   2593 O OG  . SER A 1 339 ? -40.81886 47.66099 4.17129   1.000 22.24748  ? 339 SER A OG  1 
ATOM   2594 N N   . LEU A 1 340 ? -40.69826 44.79901 1.82826   1.000 12.61026  ? 340 LEU A N   1 
ATOM   2595 C CA  . LEU A 1 340 ? -40.01608 43.50515 1.93587   1.000 14.34026  ? 340 LEU A CA  1 
ATOM   2596 C C   . LEU A 1 340 ? -38.89716 43.37117 0.90012   1.000 15.35026  ? 340 LEU A C   1 
ATOM   2597 O O   . LEU A 1 340 ? -37.80961 42.85330 1.20120   1.000 13.54026  ? 340 LEU A O   1 
ATOM   2598 C CB  . LEU A 1 340 ? -41.02731 42.37537 1.76567   1.000 13.40026  ? 340 LEU A CB  1 
ATOM   2599 C CG  . LEU A 1 340 ? -41.92901 42.13987 2.98551   1.000 15.12026  ? 340 LEU A CG  1 
ATOM   2600 C CD1 . LEU A 1 340 ? -43.04721 41.23642 2.56833   1.000 13.94026  ? 340 LEU A CD1 1 
ATOM   2601 C CD2 . LEU A 1 340 ? -41.10423 41.51988 4.12087   1.000 16.83026  ? 340 LEU A CD2 1 
ATOM   2602 N N   . THR A 1 341 ? -39.15196 43.83644 -0.32550  1.000 14.28398  ? 341 THR A N   1 
ATOM   2603 C CA  . THR A 1 341 ? -38.13466 43.79692 -1.37389  1.000 14.72398  ? 341 THR A CA  1 
ATOM   2604 C C   . THR A 1 341 ? -36.94321 44.66880 -1.00725  1.000 13.89398  ? 341 THR A C   1 
ATOM   2605 O O   . THR A 1 341 ? -35.78734 44.24531 -1.12887  1.000 11.49398  ? 341 THR A O   1 
ATOM   2606 C CB  . THR A 1 341 ? -38.74051 44.25407 -2.70234  1.000 14.44398  ? 341 THR A CB  1 
ATOM   2607 O OG1 . THR A 1 341 ? -39.83798 43.40367 -3.03472  1.000 14.25398  ? 341 THR A OG1 1 
ATOM   2608 C CG2 . THR A 1 341 ? -37.69326 44.20969 -3.82558  1.000 14.74398  ? 341 THR A CG2 1 
ATOM   2609 N N   . TYR A 1 342 ? -37.21768 45.88947 -0.54109  1.000 14.62772  ? 342 TYR A N   1 
ATOM   2610 C CA  . TYR A 1 342 ? -36.16595 46.79983 -0.10772  1.000 14.92772  ? 342 TYR A CA  1 
ATOM   2611 C C   . TYR A 1 342 ? -35.30381 46.17617 0.98770   1.000 13.87772  ? 342 TYR A C   1 
ATOM   2612 O O   . TYR A 1 342 ? -34.07157 46.28550 0.94973   1.000 15.79772  ? 342 TYR A O   1 
ATOM   2613 C CB  . TYR A 1 342 ? -36.79674 48.10718 0.37483   1.000 16.41772  ? 342 TYR A CB  1 
ATOM   2614 C CG  . TYR A 1 342 ? -35.79002 49.17379 0.70980   1.000 19.35772  ? 342 TYR A CG  1 
ATOM   2615 C CD1 . TYR A 1 342 ? -35.09007 49.83265 -0.29440  1.000 22.21772  ? 342 TYR A CD1 1 
ATOM   2616 C CD2 . TYR A 1 342 ? -35.54654 49.53224 2.02640   1.000 22.11772  ? 342 TYR A CD2 1 
ATOM   2617 C CE1 . TYR A 1 342 ? -34.15604 50.80585 0.00963   1.000 24.90772  ? 342 TYR A CE1 1 
ATOM   2618 C CE2 . TYR A 1 342 ? -34.61783 50.50282 2.34476   1.000 24.72772  ? 342 TYR A CE2 1 
ATOM   2619 C CZ  . TYR A 1 342 ? -33.92759 51.13944 1.33160   1.000 26.13772  ? 342 TYR A CZ  1 
ATOM   2620 O OH  . TYR A 1 342 ? -33.00482 52.10776 1.64855   1.000 27.96772  ? 342 TYR A OH  1 
ATOM   2621 N N   . ASP A 1 343 ? -35.93355 45.50399 1.95955   1.000 12.84119  ? 343 ASP A N   1 
ATOM   2622 C CA  . ASP A 1 343 ? -35.18193 44.81856 3.01495   1.000 14.14119  ? 343 ASP A CA  1 
ATOM   2623 C C   . ASP A 1 343 ? -34.25468 43.76124 2.43719   1.000 14.00119  ? 343 ASP A C   1 
ATOM   2624 O O   . ASP A 1 343 ? -33.15607 43.53583 2.95474   1.000 13.86119  ? 343 ASP A O   1 
ATOM   2625 C CB  . ASP A 1 343 ? -36.12930 44.14721 4.01290   1.000 16.89119  ? 343 ASP A CB  1 
ATOM   2626 C CG  . ASP A 1 343 ? -36.92048 45.14179 4.84308   1.000 21.99119  ? 343 ASP A CG  1 
ATOM   2627 O OD1 . ASP A 1 343 ? -36.58645 46.34834 4.80739   1.000 24.51119  ? 343 ASP A OD1 1 
ATOM   2628 O OD2 . ASP A 1 343 ? -37.90262 44.70640 5.50307   1.000 28.23119  ? 343 ASP A OD2 1 
ATOM   2629 N N   . GLU A 1 344 ? -34.69633 43.07932 1.38183   1.000 13.00839  ? 344 GLU A N   1 
ATOM   2630 C CA  . GLU A 1 344 ? -33.87496 42.03985 0.77868   1.000 13.74839  ? 344 GLU A CA  1 
ATOM   2631 C C   . GLU A 1 344 ? -32.72865 42.63465 -0.02958  1.000 14.39839  ? 344 GLU A C   1 
ATOM   2632 O O   . GLU A 1 344 ? -31.65379 42.02614 -0.09568  1.000 16.82839  ? 344 GLU A O   1 
ATOM   2633 C CB  . GLU A 1 344 ? -34.74727 41.13118 -0.09981  1.000 14.97839  ? 344 GLU A CB  1 
ATOM   2634 C CG  . GLU A 1 344 ? -35.76612 40.29974 0.69591   1.000 17.51839  ? 344 GLU A CG  1 
ATOM   2635 C CD  . GLU A 1 344 ? -35.12233 39.12663 1.44466   1.000 18.24839  ? 344 GLU A CD  1 
ATOM   2636 O OE1 . GLU A 1 344 ? -34.01274 38.72963 1.06058   1.000 20.29839  ? 344 GLU A OE1 1 
ATOM   2637 O OE2 . GLU A 1 344 ? -35.72664 38.59795 2.40137   1.000 22.78839  ? 344 GLU A OE2 1 
ATOM   2638 N N   . VAL A 1 345 ? -32.94901 43.79543 -0.66509  1.000 12.85421  ? 345 VAL A N   1 
ATOM   2639 C CA  . VAL A 1 345 ? -31.85530 44.52299 -1.30749  1.000 14.99421  ? 345 VAL A CA  1 
ATOM   2640 C C   . VAL A 1 345 ? -30.81870 44.93325 -0.26730  1.000 18.93421  ? 345 VAL A C   1 
ATOM   2641 O O   . VAL A 1 345 ? -29.61607 44.71036 -0.44080  1.000 17.88421  ? 345 VAL A O   1 
ATOM   2642 C CB  . VAL A 1 345 ? -32.39498 45.74151 -2.07881  1.000 16.31421  ? 345 VAL A CB  1 
ATOM   2643 C CG1 . VAL A 1 345 ? -31.23539 46.62440 -2.57604  1.000 19.67421  ? 345 VAL A CG1 1 
ATOM   2644 C CG2 . VAL A 1 345 ? -33.30351 45.31282 -3.24472  1.000 16.96421  ? 345 VAL A CG2 1 
ATOM   2645 N N   . ILE A 1 346 ? -31.28483 45.48747 0.85915   1.000 16.66526  ? 346 ILE A N   1 
ATOM   2646 C CA  . ILE A 1 346 ? -30.39692 45.96266 1.92018   1.000 19.02526  ? 346 ILE A CA  1 
ATOM   2647 C C   . ILE A 1 346 ? -29.61627 44.81199 2.55106   1.000 17.56526  ? 346 ILE A C   1 
ATOM   2648 O O   . ILE A 1 346 ? -28.43740 44.95898 2.89242   1.000 18.35526  ? 346 ILE A O   1 
ATOM   2649 C CB  . ILE A 1 346 ? -31.21988 46.74180 2.97278   1.000 22.74526  ? 346 ILE A CB  1 
ATOM   2650 C CG1 . ILE A 1 346 ? -31.74094 48.05743 2.38087   1.000 29.03526  ? 346 ILE A CG1 1 
ATOM   2651 C CG2 . ILE A 1 346 ? -30.43325 46.98366 4.26129   1.000 24.37526  ? 346 ILE A CG2 1 
ATOM   2652 C CD1 . ILE A 1 346 ? -30.65947 49.02461 2.01749   1.000 33.24526  ? 346 ILE A CD1 1 
ATOM   2653 N N   . SER A 1 347 ? -30.24242 43.65782 2.72412   1.000 17.18295  ? 347 SER A N   1 
ATOM   2654 C CA  . SER A 1 347 ? -29.57541 42.57983 3.43820   1.000 18.32295  ? 347 SER A CA  1 
ATOM   2655 C C   . SER A 1 347 ? -28.70475 41.70762 2.54296   1.000 23.26295  ? 347 SER A C   1 
ATOM   2656 O O   . SER A 1 347 ? -28.13696 40.72871 3.03453   1.000 22.39295  ? 347 SER A O   1 
ATOM   2657 C CB  . SER A 1 347 ? -30.60004 41.70391 4.16391   1.000 18.09295  ? 347 SER A CB  1 
ATOM   2658 O OG  . SER A 1 347 ? -31.41498 40.97240 3.26626   1.000 17.30295  ? 347 SER A OG  1 
ATOM   2659 N N   . PHE A 1 348 ? -28.57533 42.03566 1.25963   1.000 19.18727  ? 348 PHE A N   1 
ATOM   2660 C CA  . PHE A 1 348 ? -27.85908 41.17469 0.32898   1.000 19.73727  ? 348 PHE A CA  1 
ATOM   2661 C C   . PHE A 1 348 ? -26.36375 41.16781 0.63485   1.000 23.00727  ? 348 PHE A C   1 
ATOM   2662 O O   . PHE A 1 348 ? -25.74248 42.22448 0.76552   1.000 23.07727  ? 348 PHE A O   1 
ATOM   2663 C CB  . PHE A 1 348 ? -28.09658 41.64642 -1.10526  1.000 16.66727  ? 348 PHE A CB  1 
ATOM   2664 C CG  . PHE A 1 348 ? -27.19818 40.98366 -2.12473  1.000 17.14727  ? 348 PHE A CG  1 
ATOM   2665 C CD1 . PHE A 1 348 ? -27.46770 39.69929 -2.57252  1.000 17.56727  ? 348 PHE A CD1 1 
ATOM   2666 C CD2 . PHE A 1 348 ? -26.09913 41.65518 -2.64289  1.000 17.74727  ? 348 PHE A CD2 1 
ATOM   2667 C CE1 . PHE A 1 348 ? -26.64025 39.08196 -3.51061  1.000 18.81727  ? 348 PHE A CE1 1 
ATOM   2668 C CE2 . PHE A 1 348 ? -25.27102 41.05441 -3.57033  1.000 17.57727  ? 348 PHE A CE2 1 
ATOM   2669 C CZ  . PHE A 1 348 ? -25.54631 39.76291 -4.01123  1.000 17.06727  ? 348 PHE A CZ  1 
ATOM   2670 N N   . VAL A 1 349 ? -25.78389 39.97833 0.70930   1.000 22.35324  ? 349 VAL A N   1 
ATOM   2671 C CA  . VAL A 1 349 ? -24.35434 39.78779 0.95001   1.000 25.81324  ? 349 VAL A CA  1 
ATOM   2672 C C   . VAL A 1 349 ? -23.74042 39.18771 -0.30871  1.000 22.29324  ? 349 VAL A C   1 
ATOM   2673 O O   . VAL A 1 349 ? -24.09585 38.06205 -0.68323  1.000 22.86324  ? 349 VAL A O   1 
ATOM   2674 C CB  . VAL A 1 349 ? -24.10093 38.88654 2.16717   1.000 25.32324  ? 349 VAL A CB  1 
ATOM   2675 C CG1 . VAL A 1 349 ? -22.59003 38.68321 2.37448   1.000 32.27324  ? 349 VAL A CG1 1 
ATOM   2676 C CG2 . VAL A 1 349 ? -24.73879 39.49086 3.40657   1.000 29.40324  ? 349 VAL A CG2 1 
ATOM   2677 N N   . PRO A 1 350 ? -22.82943 39.88462 -0.98647  1.000 22.36586  ? 350 PRO A N   1 
ATOM   2678 C CA  . PRO A 1 350 ? -22.27433 39.38734 -2.26532  1.000 28.36586  ? 350 PRO A CA  1 
ATOM   2679 C C   . PRO A 1 350 ? -21.45075 38.12223 -2.07763  1.000 29.05586  ? 350 PRO A C   1 
ATOM   2680 O O   . PRO A 1 350 ? -20.93576 37.86497 -0.97994  1.000 28.59586  ? 350 PRO A O   1 
ATOM   2681 C CB  . PRO A 1 350 ? -21.39360 40.55799 -2.74889  1.000 29.47586  ? 350 PRO A CB  1 
ATOM   2682 C CG  . PRO A 1 350 ? -21.12589 41.37972 -1.52533  1.000 29.01586  ? 350 PRO A CG  1 
ATOM   2683 C CD  . PRO A 1 350 ? -22.35889 41.24291 -0.67044  1.000 25.76586  ? 350 PRO A CD  1 
ATOM   2684 N N   . PRO A 1 351 ? -21.30336 37.30597 -3.12247  1.000 31.99960  ? 351 PRO A N   1 
ATOM   2685 C CA  . PRO A 1 351 ? -20.47745 36.09801 -3.00464  1.000 38.94960  ? 351 PRO A CA  1 
ATOM   2686 C C   . PRO A 1 351 ? -19.00620 36.45846 -2.92359  1.000 40.04960  ? 351 PRO A C   1 
ATOM   2687 O O   . PRO A 1 351 ? -18.61214 37.56155 -3.33272  1.000 32.80960  ? 351 PRO A O   1 
ATOM   2688 C CB  . PRO A 1 351 ? -20.79052 35.32863 -4.29508  1.000 36.26960  ? 351 PRO A CB  1 
ATOM   2689 C CG  . PRO A 1 351 ? -21.18333 36.38414 -5.26543  1.000 34.90960  ? 351 PRO A CG  1 
ATOM   2690 C CD  . PRO A 1 351 ? -21.91715 37.42216 -4.46059  1.000 32.48960  ? 351 PRO A CD  1 
ATOM   2691 N N   . PRO A 1 352 ? -18.17072 35.56523 -2.38629  1.000 45.19399  ? 352 PRO A N   1 
ATOM   2692 C CA  . PRO A 1 352 ? -16.72294 35.82062 -2.37259  1.000 47.30399  ? 352 PRO A CA  1 
ATOM   2693 C C   . PRO A 1 352 ? -16.14560 35.89827 -3.78099  1.000 44.96399  ? 352 PRO A C   1 
ATOM   2694 O O   . PRO A 1 352 ? -16.58109 35.19277 -4.69576  1.000 44.25399  ? 352 PRO A O   1 
ATOM   2695 C CB  . PRO A 1 352 ? -16.15766 34.61789 -1.60555  1.000 49.20399  ? 352 PRO A CB  1 
ATOM   2696 C CG  . PRO A 1 352 ? -17.29442 34.12694 -0.76819  1.000 47.22399  ? 352 PRO A CG  1 
ATOM   2697 C CD  . PRO A 1 352 ? -18.52717 34.37390 -1.59449  1.000 49.80399  ? 352 PRO A CD  1 
ATOM   2698 N N   . LEU A 1 353 ? -15.16877 36.78613 -3.94873  1.000 47.50606  ? 353 LEU A N   1 
ATOM   2699 C CA  . LEU A 1 353 ? -14.42109 36.89784 -5.19870  1.000 58.69606  ? 353 LEU A CA  1 
ATOM   2700 C C   . LEU A 1 353 ? -13.48604 35.70107 -5.38243  1.000 55.96606  ? 353 LEU A C   1 
ATOM   2701 O O   . LEU A 1 353 ? -12.98481 35.45317 -6.48163  1.000 61.35606  ? 353 LEU A O   1 
ATOM   2702 C CB  . LEU A 1 353 ? -13.61839 38.19930 -5.22879  1.000 54.87606  ? 353 LEU A CB  1 
ATOM   2703 C CG  . LEU A 1 353 ? -14.41459 39.46558 -4.91166  1.000 57.75606  ? 353 LEU A CG  1 
ATOM   2704 C CD1 . LEU A 1 353 ? -13.50713 40.67710 -4.76692  1.000 54.84606  ? 353 LEU A CD1 1 
ATOM   2705 C CD2 . LEU A 1 353 ? -15.43255 39.69718 -5.99461  1.000 56.99606  ? 353 LEU A CD2 1 
ATOM   2706 N N   . GLU B 2 5   ? -15.46589 17.11077 -23.65857 1.000 65.76628  ? 50  GLU B N   1 
ATOM   2707 C CA  . GLU B 2 5   ? -15.59843 18.09585 -22.58692 1.000 62.91628  ? 50  GLU B CA  1 
ATOM   2708 C C   . GLU B 2 5   ? -14.68156 19.30624 -22.81852 1.000 66.18628  ? 50  GLU B C   1 
ATOM   2709 O O   . GLU B 2 5   ? -15.04206 20.44075 -22.48470 1.000 56.05628  ? 50  GLU B O   1 
ATOM   2710 C CB  . GLU B 2 5   ? -15.29221 17.44251 -21.22648 1.000 48.87628  ? 50  GLU B CB  1 
ATOM   2711 C CG  . GLU B 2 5   ? -15.09893 18.42332 -20.06453 1.000 46.31628  ? 50  GLU B CG  1 
ATOM   2712 C CD  . GLU B 2 5   ? -14.47011 17.79239 -18.82826 1.000 41.07628  ? 50  GLU B CD  1 
ATOM   2713 O OE1 . GLU B 2 5   ? -13.83500 16.72076 -18.94824 1.000 47.36628  ? 50  GLU B OE1 1 
ATOM   2714 O OE2 . GLU B 2 5   ? -14.60976 18.37299 -17.72695 1.000 54.93628  ? 50  GLU B OE2 1 
ATOM   2715 N N   . MET B 2 6   ? -13.53313 19.05836 -23.46307 1.000 77.53220  ? 51  MET B N   1 
ATOM   2716 C CA  . MET B 2 6   ? -12.35761 19.90903 -23.26787 1.000 74.05220  ? 51  MET B CA  1 
ATOM   2717 C C   . MET B 2 6   ? -12.54863 21.32517 -23.82190 1.000 59.80220  ? 51  MET B C   1 
ATOM   2718 O O   . MET B 2 6   ? -12.08171 22.29367 -23.21005 1.000 61.96220  ? 51  MET B O   1 
ATOM   2719 C CB  . MET B 2 6   ? -11.11068 19.22603 -23.86439 1.000 76.83220  ? 51  MET B CB  1 
ATOM   2720 C CG  . MET B 2 6   ? -10.90548 19.29513 -25.39738 1.000 77.45220  ? 51  MET B CG  1 
ATOM   2721 S SD  . MET B 2 6   ? -12.24839 18.63746 -26.43175 1.000 71.66220  ? 51  MET B SD  1 
ATOM   2722 C CE  . MET B 2 6   ? -12.20133 16.89386 -26.01018 1.000 65.38220  ? 51  MET B CE  1 
ATOM   2723 N N   . THR B 2 7   ? -13.23787 21.48079 -24.95417 1.000 63.12874  ? 52  THR B N   1 
ATOM   2724 C CA  . THR B 2 7   ? -13.28101 22.76838 -25.64451 1.000 58.51874  ? 52  THR B CA  1 
ATOM   2725 C C   . THR B 2 7   ? -14.52971 22.80268 -26.52337 1.000 44.31874  ? 52  THR B C   1 
ATOM   2726 O O   . THR B 2 7   ? -14.97051 21.76520 -27.02794 1.000 49.01874  ? 52  THR B O   1 
ATOM   2727 C CB  . THR B 2 7   ? -11.99658 23.00015 -26.48145 1.000 59.92874  ? 52  THR B CB  1 
ATOM   2728 O OG1 . THR B 2 7   ? -10.83867 22.93045 -25.63861 1.000 67.53874  ? 52  THR B OG1 1 
ATOM   2729 C CG2 . THR B 2 7   ? -11.97872 24.36463 -27.18275 1.000 59.03874  ? 52  THR B CG2 1 
ATOM   2730 N N   . LEU B 2 8   ? -15.11473 23.99590 -26.66499 1.000 37.67108  ? 53  LEU B N   1 
ATOM   2731 C CA  . LEU B 2 8   ? -16.20649 24.24725 -27.59472 1.000 37.35108  ? 53  LEU B CA  1 
ATOM   2732 C C   . LEU B 2 8   ? -15.94751 25.57738 -28.29196 1.000 37.43108  ? 53  LEU B C   1 
ATOM   2733 O O   . LEU B 2 8   ? -15.23144 26.43456 -27.77119 1.000 39.67108  ? 53  LEU B O   1 
ATOM   2734 C CB  . LEU B 2 8   ? -17.56956 24.27992 -26.87845 1.000 33.97108  ? 53  LEU B CB  1 
ATOM   2735 C CG  . LEU B 2 8   ? -18.03804 23.09283 -26.03097 1.000 35.88108  ? 53  LEU B CG  1 
ATOM   2736 C CD1 . LEU B 2 8   ? -19.34986 23.42416 -25.35516 1.000 32.29108  ? 53  LEU B CD1 1 
ATOM   2737 C CD2 . LEU B 2 8   ? -18.19571 21.83449 -26.87330 1.000 40.59108  ? 53  LEU B CD2 1 
ATOM   2738 N N   . LYS B 2 9   ? -16.54916 25.75573 -29.46839 1.000 36.16632  ? 54  LYS B N   1 
ATOM   2739 C CA  . LYS B 2 9   ? -16.41198 26.97898 -30.25380 1.000 38.87632  ? 54  LYS B CA  1 
ATOM   2740 C C   . LYS B 2 9   ? -17.56279 27.94178 -29.98406 1.000 47.14632  ? 54  LYS B C   1 
ATOM   2741 O O   . LYS B 2 9   ? -18.69823 27.51809 -29.75423 1.000 34.96632  ? 54  LYS B O   1 
ATOM   2742 C CB  . LYS B 2 9   ? -16.39219 26.68352 -31.75685 1.000 40.17632  ? 54  LYS B CB  1 
ATOM   2743 C CG  . LYS B 2 9   ? -15.50151 25.55298 -32.18885 1.000 43.49632  ? 54  LYS B CG  1 
ATOM   2744 C CD  . LYS B 2 9   ? -15.57619 25.36967 -33.69441 1.000 43.18632  ? 54  LYS B CD  1 
ATOM   2745 C CE  . LYS B 2 9   ? -14.68883 24.22125 -34.12036 1.000 42.79632  ? 54  LYS B CE  1 
ATOM   2746 N NZ  . LYS B 2 9   ? -14.60666 24.00781 -35.59265 1.000 37.61632  ? 54  LYS B NZ  1 
ATOM   2747 N N   . PHE B 2 10  ? -17.26729 29.24591 -30.07075 1.000 48.10758  ? 55  PHE B N   1 
ATOM   2748 C CA  . PHE B 2 10  ? -18.30709 30.27351 -30.02466 1.000 56.51758  ? 55  PHE B CA  1 
ATOM   2749 C C   . PHE B 2 10  ? -19.11040 30.28023 -31.31996 1.000 63.21758  ? 55  PHE B C   1 
ATOM   2750 O O   . PHE B 2 10  ? -18.56585 30.05779 -32.40493 1.000 87.49758  ? 55  PHE B O   1 
ATOM   2751 C CB  . PHE B 2 10  ? -17.68539 31.66394 -29.78184 1.000 64.48758  ? 55  PHE B CB  1 
ATOM   2752 C CG  . PHE B 2 10  ? -18.43304 32.81710 -30.45519 1.000 72.10758  ? 55  PHE B CG  1 
ATOM   2753 C CD1 . PHE B 2 10  ? -19.59324 33.34110 -29.89105 1.000 75.05758  ? 55  PHE B CD1 1 
ATOM   2754 C CD2 . PHE B 2 10  ? -17.96189 33.38280 -31.64269 1.000 71.94758  ? 55  PHE B CD2 1 
ATOM   2755 C CE1 . PHE B 2 10  ? -20.28150 34.38395 -30.50727 1.000 71.42758  ? 55  PHE B CE1 1 
ATOM   2756 C CE2 . PHE B 2 10  ? -18.64454 34.42805 -32.25969 1.000 66.17758  ? 55  PHE B CE2 1 
ATOM   2757 C CZ  . PHE B 2 10  ? -19.80337 34.92802 -31.68876 1.000 69.36758  ? 55  PHE B CZ  1 
ATOM   2758 N N   . GLY B 2 11  ? -20.41156 30.54615 -31.20041 1.000 67.60525  ? 56  GLY B N   1 
ATOM   2759 C CA  . GLY B 2 11  ? -21.26270 30.79999 -32.35215 1.000 65.37525  ? 56  GLY B CA  1 
ATOM   2760 C C   . GLY B 2 11  ? -20.82786 31.98554 -33.19521 1.000 66.92525  ? 56  GLY B C   1 
ATOM   2761 O O   . GLY B 2 11  ? -21.60092 32.51371 -33.99499 1.000 70.06525  ? 56  GLY B O   1 
HETATM 2762 O O   . HOH C 3 .   ? -19.09689 19.97464 -3.66675  1.000 38.32584  ? 401 HOH A O   1 
HETATM 2763 O O   . HOH C 3 .   ? -23.26231 43.87825 -3.70140  1.000 36.10564  ? 402 HOH A O   1 
HETATM 2764 O O   . HOH C 3 .   ? -49.36526 14.45319 -33.66464 1.000 31.34314  ? 403 HOH A O   1 
HETATM 2765 O O   . HOH C 3 .   ? -38.02400 48.26206 4.46828   1.000 22.40350  ? 404 HOH A O   1 
HETATM 2766 O O   . HOH C 3 .   ? -29.97511 9.03574  -35.73160 1.000 29.76293  ? 405 HOH A O   1 
HETATM 2767 O O   . HOH C 3 .   ? -24.59801 34.94248 -11.95712 1.000 41.73252  ? 406 HOH A O   1 
HETATM 2768 O O   . HOH C 3 .   ? -48.95455 52.53899 -2.76691  1.000 42.04092  ? 407 HOH A O   1 
HETATM 2769 O O   . HOH C 3 .   ? -17.740   22.941   -36.343   1.000 22.91070  ? 408 HOH A O   1 
HETATM 2770 O O   . HOH C 3 .   ? -48.17470 12.56221 -16.80508 1.000 32.86205  ? 409 HOH A O   1 
HETATM 2771 O O   . HOH C 3 .   ? -23.39862 7.29751  -5.92999  1.000 33.79031  ? 410 HOH A O   1 
HETATM 2772 O O   . HOH C 3 .   ? -19.76242 8.34432  -18.15158 1.000 32.27811  ? 411 HOH A O   1 
HETATM 2773 O O   . HOH C 3 .   ? -23.10377 29.87557 -10.44959 1.000 26.89170  ? 412 HOH A O   1 
HETATM 2774 O O   . HOH C 3 .   ? -57.22570 7.99251  -30.61993 1.000 37.76899  ? 413 HOH A O   1 
HETATM 2775 O O   . HOH C 3 .   ? -18.40346 7.70452  -10.97146 1.000 31.74372  ? 414 HOH A O   1 
HETATM 2776 O O   . HOH C 3 .   ? -24.72660 14.28324 -30.16415 1.000 33.15811  ? 415 HOH A O   1 
HETATM 2777 O O   . HOH C 3 .   ? -34.26386 1.95382  -18.69187 1.000 36.62695  ? 416 HOH A O   1 
HETATM 2778 O O   . HOH C 3 .   ? -29.48510 23.43930 -34.74759 1.000 26.90022  ? 417 HOH A O   1 
HETATM 2779 O O   . HOH C 3 .   ? -58.21702 4.50042  -13.28302 1.000 40.08215  ? 418 HOH A O   1 
HETATM 2780 O O   . HOH C 3 .   ? -32.49284 -0.59431 -17.03055 1.000 29.18717  ? 419 HOH A O   1 
HETATM 2781 O O   . HOH C 3 .   ? -19.31872 53.20775 -18.84332 1.000 27.86566  ? 420 HOH A O   1 
HETATM 2782 O O   . HOH C 3 .   ? -28.01904 26.71601 -0.56052  1.000 21.53009  ? 421 HOH A O   1 
HETATM 2783 O O   . HOH C 3 .   ? -25.82261 12.76461 -5.60801  1.000 25.15508  ? 422 HOH A O   1 
HETATM 2784 O O   . HOH C 3 .   ? -37.79897 15.02168 -7.09375  1.000 28.02477  ? 423 HOH A O   1 
HETATM 2785 O O   . HOH C 3 .   ? -40.54390 10.05347 -9.42021  1.000 30.46500  ? 424 HOH A O   1 
HETATM 2786 O O   . HOH C 3 .   ? -39.58914 4.38257  -20.37005 1.000 28.60435  ? 425 HOH A O   1 
HETATM 2787 O O   . HOH C 3 .   ? -24.93505 46.32457 -4.00768  1.000 32.58307  ? 426 HOH A O   1 
HETATM 2788 O O   . HOH C 3 .   ? -34.25276 47.09534 5.58995   1.000 29.71536  ? 427 HOH A O   1 
HETATM 2789 O O   . HOH C 3 .   ? -38.10804 38.87538 3.42731   1.000 21.32638  ? 428 HOH A O   1 
HETATM 2790 O O   . HOH C 3 .   ? -23.14429 7.89061  -12.23410 1.000 17.87259  ? 429 HOH A O   1 
HETATM 2791 O O   . HOH C 3 .   ? -22.34204 15.56447 -2.42188  1.000 26.81254  ? 430 HOH A O   1 
HETATM 2792 O O   . HOH C 3 .   ? -40.56591 42.15011 -11.22263 1.000 29.55925  ? 431 HOH A O   1 
HETATM 2793 O O   . HOH C 3 .   ? -23.13277 47.65775 -6.27223  1.000 21.59580  ? 432 HOH A O   1 
HETATM 2794 O O   . HOH C 3 .   ? -30.03172 0.75529  -24.21824 1.000 28.08893  ? 433 HOH A O   1 
HETATM 2795 O O   . HOH C 3 .   ? -27.10998 47.16446 3.36993   1.000 34.40098  ? 434 HOH A O   1 
HETATM 2796 O O   . HOH C 3 .   ? -45.83107 16.31992 -12.45268 1.000 31.24697  ? 435 HOH A O   1 
HETATM 2797 O O   . HOH C 3 .   ? -25.48702 35.42007 -4.50002  1.000 22.48434  ? 436 HOH A O   1 
HETATM 2798 O O   . HOH C 3 .   ? -49.53999 50.22950 -0.37575  1.000 24.97081  ? 437 HOH A O   1 
HETATM 2799 O O   . HOH C 3 .   ? -24.76019 35.85367 -1.94770  1.000 28.09676  ? 438 HOH A O   1 
HETATM 2800 O O   . HOH C 3 .   ? -27.17192 10.48807 -6.04487  1.000 28.45657  ? 439 HOH A O   1 
HETATM 2801 O O   . HOH C 3 .   ? -29.02469 29.05315 0.02284   1.000 24.33303  ? 440 HOH A O   1 
HETATM 2802 O O   . HOH C 3 .   ? -23.94291 60.93111 -16.52007 1.000 45.77029  ? 441 HOH A O   1 
HETATM 2803 O O   . HOH C 3 .   ? -15.21249 12.30669 -27.33881 1.000 46.41372  ? 442 HOH A O   1 
HETATM 2804 O O   . HOH C 3 .   ? -29.11552 18.80373 -31.00655 1.000 21.69464  ? 443 HOH A O   1 
HETATM 2805 O O   . HOH C 3 .   ? -30.86470 52.26537 -0.09056  1.000 24.41727  ? 444 HOH A O   1 
HETATM 2806 O O   . HOH C 3 .   ? -47.36465 38.01599 -8.35087  1.000 26.62276  ? 445 HOH A O   1 
HETATM 2807 O O   . HOH C 3 .   ? -34.04379 10.64198 -5.13575  1.000 31.18992  ? 446 HOH A O   1 
HETATM 2808 O O   . HOH C 3 .   ? -33.24260 28.25811 5.17412   1.000 25.81691  ? 447 HOH A O   1 
HETATM 2809 O O   . HOH C 3 .   ? -41.87916 49.21891 6.04856   1.000 36.91013  ? 448 HOH A O   1 
HETATM 2810 O O   . HOH C 3 .   ? -35.38531 15.48602 -8.58242  1.000 14.94869  ? 449 HOH A O   1 
HETATM 2811 O O   . HOH C 3 .   ? -50.73805 37.28634 -2.38171  1.000 29.77078  ? 450 HOH A O   1 
HETATM 2812 O O   . HOH C 3 .   ? -48.26329 4.46073  -13.53464 1.000 37.70380  ? 451 HOH A O   1 
HETATM 2813 O O   . HOH C 3 .   ? -27.36054 33.76226 -5.49559  1.000 16.02759  ? 452 HOH A O   1 
HETATM 2814 O O   . HOH C 3 .   ? -18.37400 53.99978 -6.36122  1.000 30.16588  ? 453 HOH A O   1 
HETATM 2815 O O   . HOH C 3 .   ? -41.72876 31.00213 -4.49350  1.000 27.66766  ? 454 HOH A O   1 
HETATM 2816 O O   . HOH C 3 .   ? -40.27455 13.93646 -7.11446  1.000 37.03139  ? 455 HOH A O   1 
HETATM 2817 O O   . HOH C 3 .   ? -39.33428 25.56625 -0.73035  1.000 28.23482  ? 456 HOH A O   1 
HETATM 2818 O O   . HOH C 3 .   ? -42.47260 39.90113 7.11261   1.000 28.55728  ? 457 HOH A O   1 
HETATM 2819 O O   . HOH C 3 .   ? -47.22924 3.55965  -29.58036 1.000 29.92539  ? 458 HOH A O   1 
HETATM 2820 O O   . HOH C 3 .   ? -53.52502 42.90138 2.59277   1.000 30.75780  ? 459 HOH A O   1 
HETATM 2821 O O   . HOH C 3 .   ? -32.23385 51.89080 4.21372   1.000 37.88554  ? 460 HOH A O   1 
HETATM 2822 O O   . HOH C 3 .   ? -42.04131 20.10010 -17.94223 1.000 20.63852  ? 461 HOH A O   1 
HETATM 2823 O O   . HOH C 3 .   ? -29.10846 39.69116 -14.66637 1.000 32.32506  ? 462 HOH A O   1 
HETATM 2824 O O   . HOH C 3 .   ? -53.30194 5.98532  -8.84630  1.000 38.02361  ? 463 HOH A O   1 
HETATM 2825 O O   . HOH C 3 .   ? -41.57895 22.74489 -18.76022 1.000 23.92066  ? 464 HOH A O   1 
HETATM 2826 O O   . HOH C 3 .   ? -28.22211 53.33723 -3.10263  1.000 27.26733  ? 465 HOH A O   1 
HETATM 2827 O O   . HOH C 3 .   ? -23.65390 4.91887  -9.25643  1.000 37.52164  ? 466 HOH A O   1 
HETATM 2828 O O   . HOH C 3 .   ? -39.03098 28.86546 -10.51643 1.000 39.57504  ? 467 HOH A O   1 
HETATM 2829 O O   . HOH C 3 .   ? -21.04097 5.50067  -21.43968 1.000 32.94171  ? 468 HOH A O   1 
HETATM 2830 O O   . HOH C 3 .   ? -27.20542 46.99380 -2.92313  1.000 24.34850  ? 469 HOH A O   1 
HETATM 2831 O O   . HOH C 3 .   ? -41.58622 5.73017  -21.36922 1.000 28.95398  ? 470 HOH A O   1 
HETATM 2832 O O   . HOH C 3 .   ? -24.69839 60.75302 -13.75767 1.000 36.43258  ? 471 HOH A O   1 
HETATM 2833 O O   . HOH C 3 .   ? -32.77274 16.86192 -4.87942  1.000 13.01772  ? 472 HOH A O   1 
HETATM 2834 O O   . HOH C 3 .   ? -38.12022 5.89486  -14.31493 1.000 19.36168  ? 473 HOH A O   1 
HETATM 2835 O O   . HOH C 3 .   ? -26.51671 59.58185 -10.65216 1.000 37.85197  ? 474 HOH A O   1 
HETATM 2836 O O   . HOH C 3 .   ? -39.09706 17.77374 -27.55590 1.000 17.79755  ? 475 HOH A O   1 
HETATM 2837 O O   . HOH C 3 .   ? -24.82897 23.65634 -1.02455  1.000 28.39780  ? 476 HOH A O   1 
HETATM 2838 O O   . HOH C 3 .   ? -29.71039 21.51741 3.59909   1.000 33.61040  ? 477 HOH A O   1 
HETATM 2839 O O   . HOH C 3 .   ? -14.731   49.017   -9.280    1.000 33.41869  ? 478 HOH A O   1 
HETATM 2840 O O   . HOH C 3 .   ? -21.69677 60.36130 -10.79348 1.000 32.57888  ? 479 HOH A O   1 
HETATM 2841 O O   . HOH C 3 .   ? -39.90554 23.49161 -20.75856 1.000 23.66902  ? 480 HOH A O   1 
HETATM 2842 O O   . HOH C 3 .   ? -21.82978 2.38168  -23.13107 1.000 37.25634  ? 481 HOH A O   1 
HETATM 2843 O O   . HOH C 3 .   ? -43.24000 10.45986 -31.16803 1.000 29.24359  ? 482 HOH A O   1 
HETATM 2844 O O   . HOH C 3 .   ? -25.64434 19.17999 -6.63821  1.000 11.22424  ? 483 HOH A O   1 
HETATM 2845 O O   . HOH C 3 .   ? -24.03942 24.36377 -3.84762  1.000 17.80488  ? 484 HOH A O   1 
HETATM 2846 O O   . HOH C 3 .   ? -37.95894 41.97088 5.76295   1.000 33.09988  ? 485 HOH A O   1 
HETATM 2847 O O   . HOH C 3 .   ? -34.27107 33.99019 -0.11917  1.000 14.19525  ? 486 HOH A O   1 
HETATM 2848 O O   . HOH C 3 .   ? -32.456   18.575   -37.406   1.000 13.22252  ? 487 HOH A O   1 
HETATM 2849 O O   . HOH C 3 .   ? -33.14663 36.09688 1.28021   1.000 20.44579  ? 488 HOH A O   1 
HETATM 2850 O O   . HOH C 3 .   ? -41.80186 12.45681 -32.20100 1.000 27.83222  ? 489 HOH A O   1 
HETATM 2851 O O   . HOH C 3 .   ? -26.989   6.353    -35.196   1.000 21.17055  ? 490 HOH A O   1 
HETATM 2852 O O   . HOH C 3 .   ? -15.62296 53.06597 -19.55315 1.000 29.44868  ? 491 HOH A O   1 
HETATM 2853 O O   . HOH C 3 .   ? -25.89169 29.85585 -7.92208  1.000 13.99144  ? 492 HOH A O   1 
HETATM 2854 O O   . HOH C 3 .   ? -41.07530 55.37107 -4.18751  1.000 44.17998  ? 493 HOH A O   1 
HETATM 2855 O O   . HOH C 3 .   ? -36.84548 23.77227 1.04275   1.000 30.83965  ? 494 HOH A O   1 
HETATM 2856 O O   . HOH C 3 .   ? -30.10619 7.35865  -33.25758 1.000 24.49645  ? 495 HOH A O   1 
HETATM 2857 O O   . HOH C 3 .   ? -25.59073 54.24622 -15.85215 1.000 27.80808  ? 496 HOH A O   1 
HETATM 2858 O O   . HOH C 3 .   ? -35.23953 53.78431 -6.95916  1.000 29.81573  ? 497 HOH A O   1 
HETATM 2859 O O   . HOH C 3 .   ? -36.27353 17.70821 -27.79820 1.000 16.01188  ? 498 HOH A O   1 
HETATM 2860 O O   . HOH C 3 .   ? -32.16167 20.43179 1.22787   1.000 31.23109  ? 499 HOH A O   1 
HETATM 2861 O O   . HOH C 3 .   ? -34.44847 24.79464 -28.42017 1.000 29.38073  ? 500 HOH A O   1 
HETATM 2862 O O   . HOH C 3 .   ? -38.99313 22.29503 -16.91254 1.000 16.32600  ? 501 HOH A O   1 
HETATM 2863 O O   . HOH C 3 .   ? -36.05255 -5.45463 -28.43583 1.000 29.29538  ? 502 HOH A O   1 
HETATM 2864 O O   . HOH C 3 .   ? -27.32713 37.62809 0.40849   1.000 23.43909  ? 503 HOH A O   1 
HETATM 2865 O O   . HOH C 3 .   ? -34.77736 13.28132 -30.89948 1.000 25.49835  ? 504 HOH A O   1 
HETATM 2866 O O   . HOH C 3 .   ? -33.69031 31.95575 1.47525   1.000 23.61101  ? 505 HOH A O   1 
HETATM 2867 O O   . HOH C 3 .   ? -27.20454 14.21253 -1.17348  1.000 40.21038  ? 506 HOH A O   1 
HETATM 2868 O O   . HOH C 3 .   ? -48.93395 11.68603 -34.32567 1.000 36.13446  ? 507 HOH A O   1 
HETATM 2869 O O   . HOH C 3 .   ? -39.80485 4.28791  -11.15708 1.000 37.05384  ? 508 HOH A O   1 
HETATM 2870 O O   . HOH C 3 .   ? -34.89679 0.68545  -24.86890 1.000 32.36223  ? 509 HOH A O   1 
HETATM 2871 O O   . HOH C 3 .   ? -42.20709 32.02302 7.84958   1.000 29.14376  ? 510 HOH A O   1 
HETATM 2872 O O   . HOH C 3 .   ? -26.188   13.773   -33.242   1.000 27.73314  ? 511 HOH A O   1 
HETATM 2873 O O   . HOH C 3 .   ? -18.44551 30.94261 -17.97804 1.000 48.18717  ? 512 HOH A O   1 
HETATM 2874 O O   . HOH C 3 .   ? -24.65764 8.50212  -27.75590 1.000 23.72586  ? 513 HOH A O   1 
HETATM 2875 O O   . HOH C 3 .   ? -29.214   18.676   -36.593   1.000 24.05727  ? 514 HOH A O   1 
HETATM 2876 O O   . HOH C 3 .   ? -14.41341 21.29185 -18.43560 1.000 38.58746  ? 515 HOH A O   1 
HETATM 2877 O O   . HOH C 3 .   ? -20.76825 26.33391 -14.34739 1.000 27.58735  ? 516 HOH A O   1 
HETATM 2878 O O   . HOH C 3 .   ? -38.13337 15.28628 -35.09716 1.000 28.96906  ? 517 HOH A O   1 
HETATM 2879 O O   . HOH C 3 .   ? -42.05484 26.77540 2.35095   1.000 18.24420  ? 518 HOH A O   1 
HETATM 2880 O O   . HOH C 3 .   ? -24.06564 58.57221 -6.22275  1.000 25.00742  ? 519 HOH A O   1 
HETATM 2881 O O   . HOH C 3 .   ? -40.77046 26.18959 -7.23338  1.000 31.42215  ? 520 HOH A O   1 
HETATM 2882 O O   . HOH C 3 .   ? -60.58941 11.55088 -29.21837 1.000 35.51989  ? 521 HOH A O   1 
HETATM 2883 O O   . HOH C 3 .   ? -53.96983 19.52054 -33.83904 1.000 40.43100  ? 522 HOH A O   1 
HETATM 2884 O O   . HOH C 3 .   ? -42.51754 17.51146 -24.31359 1.000 17.99141  ? 523 HOH A O   1 
HETATM 2885 O O   . HOH C 3 .   ? -35.08514 31.62173 -22.65877 1.000 38.63493  ? 524 HOH A O   1 
HETATM 2886 O O   . HOH C 3 .   ? -52.51037 46.25309 -7.29445  1.000 28.23440  ? 525 HOH A O   1 
HETATM 2887 O O   . HOH C 3 .   ? -29.66977 5.31703  -10.99182 1.000 30.78162  ? 526 HOH A O   1 
HETATM 2888 O O   . HOH C 3 .   ? -27.67797 36.03297 -1.59548  1.000 25.28161  ? 527 HOH A O   1 
HETATM 2889 O O   . HOH C 3 .   ? -35.51507 30.66755 3.14290   1.000 23.92572  ? 528 HOH A O   1 
HETATM 2890 O O   . HOH C 3 .   ? -50.45927 39.81580 -1.88890  1.000 22.41122  ? 529 HOH A O   1 
HETATM 2891 O O   . HOH C 3 .   ? -30.50967 1.99942  -29.22270 1.000 32.54828  ? 530 HOH A O   1 
HETATM 2892 O O   . HOH C 3 .   ? -19.59770 10.42823 -29.89912 1.000 33.24351  ? 531 HOH A O   1 
HETATM 2893 O O   . HOH C 3 .   ? -29.54260 38.08764 2.67521   1.000 28.62484  ? 532 HOH A O   1 
HETATM 2894 O O   . HOH C 3 .   ? -32.23588 8.13730  -34.06779 1.000 31.38970  ? 533 HOH A O   1 
HETATM 2895 O O   . HOH C 3 .   ? -20.18522 40.88768 -6.46176  1.000 34.97091  ? 534 HOH A O   1 
HETATM 2896 O O   . HOH C 3 .   ? -35.63222 53.39184 4.38725   1.000 40.88096  ? 535 HOH A O   1 
HETATM 2897 O O   . HOH C 3 .   ? -51.39493 46.37704 6.60546   1.000 30.12626  ? 536 HOH A O   1 
HETATM 2898 O O   . HOH C 3 .   ? -64.10489 8.72036  -22.54392 1.000 41.89687  ? 537 HOH A O   1 
HETATM 2899 O O   . HOH C 3 .   ? -28.42028 49.30951 -3.41303  1.000 19.59721  ? 538 HOH A O   1 
HETATM 2900 O O   . HOH C 3 .   ? -21.53930 28.39739 -17.77779 1.000 31.84060  ? 539 HOH A O   1 
HETATM 2901 O O   . HOH C 3 .   ? -52.334   1.175    -14.422   1.000 37.73751  ? 540 HOH A O   1 
HETATM 2902 O O   . HOH C 3 .   ? -19.68888 22.16627 -13.36934 1.000 29.19972  ? 541 HOH A O   1 
HETATM 2903 O O   . HOH C 3 .   ? -24.80710 19.04430 0.51171   1.000 29.85599  ? 542 HOH A O   1 
HETATM 2904 O O   . HOH C 3 .   ? -46.02589 5.85301  -16.92861 1.000 26.80951  ? 543 HOH A O   1 
HETATM 2905 O O   . HOH C 3 .   ? -36.37689 54.61129 -17.67009 1.000 43.66283  ? 544 HOH A O   1 
HETATM 2906 O O   . HOH C 3 .   ? -24.02193 7.71024  -32.39522 1.000 41.44096  ? 545 HOH A O   1 
HETATM 2907 O O   . HOH C 3 .   ? -26.32741 22.81673 2.01231   1.000 33.39685  ? 546 HOH A O   1 
HETATM 2908 O O   . HOH C 3 .   ? -47.98955 12.54379 -14.11350 1.000 29.62586  ? 547 HOH A O   1 
HETATM 2909 O O   . HOH C 3 .   ? -44.49162 5.84315  -19.90712 1.000 31.52946  ? 548 HOH A O   1 
HETATM 2910 O O   . HOH C 3 .   ? -26.94178 17.83796 -31.22598 1.000 22.25761  ? 549 HOH A O   1 
HETATM 2911 O O   . HOH C 3 .   ? -26.92018 46.07415 -0.47328  1.000 35.20571  ? 550 HOH A O   1 
HETATM 2912 O O   . HOH C 3 .   ? -33.46586 14.73254 -6.65086  1.000 16.15544  ? 551 HOH A O   1 
HETATM 2913 O O   . HOH C 3 .   ? -22.01268 23.85038 -6.27927  1.000 30.76506  ? 552 HOH A O   1 
HETATM 2914 O O   . HOH C 3 .   ? -27.34185 2.54927  -14.16282 1.000 21.71011  ? 553 HOH A O   1 
HETATM 2915 O O   . HOH C 3 .   ? -27.81725 3.68563  -10.02032 1.000 34.38725  ? 554 HOH A O   1 
HETATM 2916 O O   . HOH C 3 .   ? -34.93919 26.53153 -26.33281 1.000 20.80558  ? 555 HOH A O   1 
HETATM 2917 O O   . HOH C 3 .   ? -52.32913 43.55633 -8.30720  1.000 31.76864  ? 556 HOH A O   1 
HETATM 2918 O O   . HOH C 3 .   ? -50.48990 4.11373  -15.07460 1.000 37.81315  ? 557 HOH A O   1 
HETATM 2919 O O   . HOH C 3 .   ? -36.91643 28.94270 -26.56515 1.000 36.79696  ? 558 HOH A O   1 
HETATM 2920 O O   . HOH C 3 .   ? -17.34918 10.72996 -27.14858 1.000 38.40970  ? 559 HOH A O   1 
HETATM 2921 O O   . HOH C 3 .   ? -41.27703 20.94083 -4.71782  1.000 36.98592  ? 560 HOH A O   1 
HETATM 2922 O O   . HOH C 3 .   ? -18.89517 51.34162 -7.72884  1.000 22.06242  ? 561 HOH A O   1 
HETATM 2923 O O   . HOH C 3 .   ? -20.30667 5.45779  -18.90734 1.000 36.64114  ? 562 HOH A O   1 
HETATM 2924 O O   . HOH C 3 .   ? -61.07253 5.44855  -29.64167 1.000 49.35681  ? 563 HOH A O   1 
HETATM 2925 O O   . HOH C 3 .   ? -52.20424 47.55058 -2.18285  1.000 23.79505  ? 564 HOH A O   1 
HETATM 2926 O O   . HOH C 3 .   ? -25.92377 9.56972  -30.41991 1.000 38.34216  ? 565 HOH A O   1 
HETATM 2927 O O   . HOH C 3 .   ? -49.05047 34.94360 -6.08652  1.000 35.77137  ? 566 HOH A O   1 
HETATM 2928 O O   . HOH C 3 .   ? -19.14734 12.91189 -32.79475 1.000 35.82014  ? 567 HOH A O   1 
HETATM 2929 O O   . HOH C 3 .   ? -24.43770 15.95446 -0.84813  1.000 37.17408  ? 568 HOH A O   1 
HETATM 2930 O O   . HOH C 3 .   ? -20.74553 47.71421 -5.64134  1.000 31.83959  ? 569 HOH A O   1 
HETATM 2931 O O   . HOH C 3 .   ? -30.87091 28.17947 6.20576   1.000 36.58101  ? 570 HOH A O   1 
HETATM 2932 O O   . HOH C 3 .   ? -37.258   5.956    -10.003   1.000 33.23029  ? 571 HOH A O   1 
HETATM 2933 O O   . HOH C 3 .   ? -26.73018 29.75752 2.30862   1.000 39.34403  ? 572 HOH A O   1 
HETATM 2934 O O   . HOH C 3 .   ? -35.46258 16.63010 -4.00748  1.000 28.39727  ? 573 HOH A O   1 
HETATM 2935 O O   . HOH C 3 .   ? -34.17267 -3.80876 -28.78289 1.000 32.22205  ? 574 HOH A O   1 
HETATM 2936 O O   . HOH C 3 .   ? -25.27684 8.68053  -5.49866  1.000 36.85061  ? 575 HOH A O   1 
HETATM 2937 O O   . HOH C 3 .   ? -38.27506 12.25775 -32.83477 1.000 29.89023  ? 576 HOH A O   1 
HETATM 2938 O O   . HOH C 3 .   ? -17.86381 15.18277 -33.41700 1.000 36.66301  ? 577 HOH A O   1 
HETATM 2939 O O   . HOH C 3 .   ? -29.56185 33.03720 1.13267   1.000 35.15549  ? 578 HOH A O   1 
HETATM 2940 O O   . HOH C 3 .   ? -25.39192 26.53561 -0.81604  1.000 32.60994  ? 579 HOH A O   1 
HETATM 2941 O O   . HOH C 3 .   ? -36.20185 11.44528 -32.37179 1.000 28.38017  ? 580 HOH A O   1 
HETATM 2942 O O   . HOH C 3 .   ? -16.036   51.402   -8.665    1.000 33.96541  ? 581 HOH A O   1 
HETATM 2943 O O   . HOH C 3 .   ? -49.20001 51.22347 2.23397   1.000 36.94665  ? 582 HOH A O   1 
HETATM 2944 O O   . HOH C 3 .   ? -47.93393 24.55599 -22.06542 1.000 39.48343  ? 583 HOH A O   1 
HETATM 2945 O O   . HOH C 3 .   ? -45.38218 49.18017 4.26196   1.000 36.76974  ? 584 HOH A O   1 
HETATM 2946 O O   . HOH C 3 .   ? -31.64149 37.92618 -14.05219 1.000 40.03408  ? 585 HOH A O   1 
HETATM 2947 O O   . HOH C 3 .   ? -41.62327 24.58366 0.03732   1.000 37.79203  ? 586 HOH A O   1 
HETATM 2948 O O   . HOH C 3 .   ? -35.413   43.728   7.846     1.000 38.37708  ? 587 HOH A O   1 
HETATM 2949 O O   . HOH C 3 .   ? -34.42664 13.03687 -4.73332  1.000 30.02720  ? 588 HOH A O   1 
HETATM 2950 O O   . HOH C 3 .   ? -28.24948 11.40800 -3.31412  1.000 40.12510  ? 589 HOH A O   1 
HETATM 2951 O O   . HOH C 3 .   ? -29.39249 30.64550 2.01796   1.000 36.18270  ? 590 HOH A O   1 
HETATM 2952 O O   . HOH C 3 .   ? -36.69257 9.33761  -4.37329  1.000 40.38972  ? 591 HOH A O   1 
HETATM 2953 O O   . HOH C 3 .   ? -41.58754 15.07060 -5.12976  1.000 38.78819  ? 592 HOH A O   1 
HETATM 2954 O O   . HOH C 3 .   ? -36.762   8.589    -35.359   1.000 43.49575  ? 593 HOH A O   1 
HETATM 2955 O O   . HOH C 3 .   ? -20.75101 27.10665 -5.50204  1.000 33.70456  ? 594 HOH A O   1 
HETATM 2956 O O   . HOH C 3 .   ? -15.02575 9.41790  -11.08230 1.000 40.78595  ? 595 HOH A O   1 
HETATM 2957 O O   . HOH C 3 .   ? -26.17408 50.83461 -3.32392  1.000 31.51594  ? 596 HOH A O   1 
HETATM 2958 O O   . HOH C 3 .   ? -50.32583 49.13641 6.54052   1.000 37.95505  ? 597 HOH A O   1 
HETATM 2959 O O   . HOH C 3 .   ? -14.85630 11.50416 -10.31474 1.000 34.13154  ? 598 HOH A O   1 
HETATM 2960 O O   . HOH C 3 .   ? -21.62530 5.96038  -11.11477 1.000 28.60634  ? 599 HOH A O   1 
HETATM 2961 O O   . HOH C 3 .   ? -36.97365 13.57706 -4.59127  1.000 34.40793  ? 600 HOH A O   1 
HETATM 2962 O O   . HOH C 3 .   ? -27.69533 32.56323 -22.30657 1.000 34.22512  ? 601 HOH A O   1 
HETATM 2963 O O   . HOH C 3 .   ? -25.43511 50.46256 -0.76803  1.000 41.11154  ? 602 HOH A O   1 
HETATM 2964 O O   . HOH C 3 .   ? -23.08064 22.56918 0.32100   1.000 32.57548  ? 603 HOH A O   1 
HETATM 2965 O O   . HOH C 3 .   ? -35.648   8.997    -38.106   1.000 36.43208  ? 604 HOH A O   1 
HETATM 2966 O O   . HOH C 3 .   ? -24.35666 45.62948 3.26775   1.000 38.85697  ? 605 HOH A O   1 
HETATM 2967 O O   . HOH C 3 .   ? -21.90912 3.39516  -12.50047 1.000 31.18613  ? 606 HOH A O   1 
HETATM 2968 O O   . HOH C 3 .   ? -46.35125 3.88530  -14.94824 1.000 32.79885  ? 607 HOH A O   1 
HETATM 2969 O O   . HOH C 3 .   ? -24.55048 2.27912  -8.48773  1.000 38.04100  ? 608 HOH A O   1 
HETATM 2970 O O   . HOH C 3 .   ? -52.058   49.920   -1.106    1.000 23.51844  ? 609 HOH A O   1 
HETATM 2971 O O   . HOH C 3 .   ? -27.34974 48.41859 0.49489   1.000 34.58317  ? 610 HOH A O   1 
HETATM 2972 O O   . HOH C 3 .   ? -55.31275 9.89547  -31.41582 1.000 39.83646  ? 611 HOH A O   1 
HETATM 2973 O O   . HOH C 3 .   ? -29.60881 49.94412 -0.94195  1.000 33.39175  ? 612 HOH A O   1 
HETATM 2974 O O   . HOH C 3 .   ? -31.56698 15.46096 -2.84339  1.000 21.82977  ? 613 HOH A O   1 
HETATM 2975 O O   . HOH C 3 .   ? -24.97810 48.69131 -4.15151  1.000 38.44378  ? 614 HOH A O   1 
HETATM 2976 O O   . HOH C 3 .   ? -47.73923 49.84384 4.49390   1.000 42.22992  ? 615 HOH A O   1 
HETATM 2977 O O   . HOH C 3 .   ? -53.993   41.925   -6.810    1.000 43.94838  ? 616 HOH A O   1 
HETATM 2978 O O   . HOH C 3 .   ? -31.15745 4.04497  -12.61028 1.000 32.69032  ? 617 HOH A O   1 
HETATM 2979 O O   . HOH C 3 .   ? -51.782   51.806   -3.045    1.000 36.11491  ? 618 HOH A O   1 
HETATM 2980 O O   . HOH C 3 .   ? -32.56097 16.38346 -0.48956  1.000 33.02812  ? 619 HOH A O   1 
HETATM 2981 O O   . HOH C 3 .   ? -19.01518 49.43258 -6.07588  1.000 22.72296  ? 620 HOH A O   1 
HETATM 2982 O O   . HOH C 3 .   ? -21.86723 20.07855 0.28913   1.000 40.64659  ? 621 HOH A O   1 
HETATM 2983 O O   . HOH C 3 .   ? -22.77765 48.25064 2.36016   1.000 47.77547  ? 622 HOH A O   1 
HETATM 2984 O O   . HOH C 3 .   ? -19.86401 22.66616 -2.32286  1.000 41.34309  ? 623 HOH A O   1 
HETATM 2985 O O   . HOH C 3 .   ? -32.36463 12.97808 -2.84318  1.000 36.43463  ? 624 HOH A O   1 
HETATM 2986 O O   . HOH C 3 .   ? -15.21415 13.79414 -32.60682 1.000 45.94046  ? 625 HOH A O   1 
HETATM 2987 O O   . HOH C 3 .   ? -31.07850 10.77176 -2.25739  1.000 50.45831  ? 626 HOH A O   1 
HETATM 2988 O O   . HOH D 3 .   ? -12.237   23.191   -36.015   1.000 24.35530  ? 101 HOH B O   1 
HETATM 2989 O O   . HOH D 3 .   ? -15.010   25.609   -37.539   1.000 34.77573  ? 102 HOH B O   1 
HETATM 2990 O O   . HOH D 3 .   ? -13.388   25.138   -39.732   1.000 26.77967  ? 103 HOH B O   1 
HETATM 2991 O O   . HOH D 3 .   ? -11.696   20.108   -35.505   1.000 35.85622  ? 104 HOH B O   1 
# 
