data_8YPE
# 
_entry.id   8YPE 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YPE         pdb_00008ype 10.2210/pdb8ype/pdb 
WWPDB D_1300045000 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-19 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YPE 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 jiaweiwu@suda.edu.cn            Jia-Wei Wu   ? 'principal investigator/group leader' 0000-0003-0273-1686 
3 zhixinwang@mail.tsinghua.edu.cn Zhi-Xin Wang ? 'principal investigator/group leader' 0000-0003-4656-2941 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, Y.Y.' 1 ? 
'Pei, C.J.'   2 ? 
'He, Q.Q.'    3 ? 
'Luo, Z.P.'   4 ? 
'Wu, J.W.'    5 ? 
'Wang, Z.X.'  6 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural and mechanistic insights into the allosteric activation of p38alpha MAP kinase via specific docking interactions' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, Y.Y.' 1 ? 
primary 'Pei, C.J.'   2 ? 
primary 'He, Q.Q.'    3 ? 
primary 'Luo, Z.P.'   4 ? 
primary 'Wu, J.W.'    5 ? 
primary 'Wang, Z.X.'  6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Cyclic AMP-dependent transcription factor ATF-2' 4018.619  1   ?         ? ? ? 
2 polymer man 'Mitogen-activated protein kinase 14'             41575.438 1   2.7.11.24 ? ? ? 
3 water   nat water                                             18.015    304 ?         ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;cAMP-dependent transcription factor ATF-2,Activating transcription factor 2,Cyclic AMP-responsive element-binding protein 2,CREB-2,cAMP-responsive element-binding protein 2,HB16,cAMP response element-binding protein CRE-BP1
;
2 'MAP kinase 14,MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no KHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCE KHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCE B ? 
2 'polypeptide(L)' no no 
;VHMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHM
KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV
NEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL
VGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEP
VADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
;VHMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHM
KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV
NEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL
VGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEP
VADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
A ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   HIS n 
1 3   LYS n 
1 4   HIS n 
1 5   GLU n 
1 6   MET n 
1 7   THR n 
1 8   LEU n 
1 9   LYS n 
1 10  PHE n 
1 11  GLY n 
1 12  PRO n 
1 13  ALA n 
1 14  ARG n 
1 15  ASN n 
1 16  ASP n 
1 17  SER n 
1 18  VAL n 
1 19  ILE n 
1 20  VAL n 
1 21  ALA n 
1 22  ASP n 
1 23  GLN n 
1 24  THR n 
1 25  PRO n 
1 26  THR n 
1 27  PRO n 
1 28  THR n 
1 29  ARG n 
1 30  PHE n 
1 31  LEU n 
1 32  LYS n 
1 33  ASN n 
1 34  CYS n 
1 35  GLU n 
2 1   VAL n 
2 2   HIS n 
2 3   MET n 
2 4   SER n 
2 5   GLN n 
2 6   GLU n 
2 7   ARG n 
2 8   PRO n 
2 9   THR n 
2 10  PHE n 
2 11  TYR n 
2 12  ARG n 
2 13  GLN n 
2 14  GLU n 
2 15  LEU n 
2 16  ASN n 
2 17  LYS n 
2 18  THR n 
2 19  ILE n 
2 20  TRP n 
2 21  GLU n 
2 22  VAL n 
2 23  PRO n 
2 24  GLU n 
2 25  ARG n 
2 26  TYR n 
2 27  GLN n 
2 28  ASN n 
2 29  LEU n 
2 30  SER n 
2 31  PRO n 
2 32  VAL n 
2 33  GLY n 
2 34  SER n 
2 35  GLY n 
2 36  ALA n 
2 37  TYR n 
2 38  GLY n 
2 39  SER n 
2 40  VAL n 
2 41  CYS n 
2 42  ALA n 
2 43  ALA n 
2 44  PHE n 
2 45  ASP n 
2 46  THR n 
2 47  LYS n 
2 48  THR n 
2 49  GLY n 
2 50  HIS n 
2 51  ARG n 
2 52  VAL n 
2 53  ALA n 
2 54  VAL n 
2 55  LYS n 
2 56  LYS n 
2 57  LEU n 
2 58  SER n 
2 59  ARG n 
2 60  PRO n 
2 61  PHE n 
2 62  GLN n 
2 63  SER n 
2 64  ILE n 
2 65  ILE n 
2 66  HIS n 
2 67  ALA n 
2 68  LYS n 
2 69  ARG n 
2 70  THR n 
2 71  TYR n 
2 72  ARG n 
2 73  GLU n 
2 74  LEU n 
2 75  ARG n 
2 76  LEU n 
2 77  LEU n 
2 78  LYS n 
2 79  HIS n 
2 80  MET n 
2 81  LYS n 
2 82  HIS n 
2 83  GLU n 
2 84  ASN n 
2 85  VAL n 
2 86  ILE n 
2 87  GLY n 
2 88  LEU n 
2 89  LEU n 
2 90  ASP n 
2 91  VAL n 
2 92  PHE n 
2 93  THR n 
2 94  PRO n 
2 95  ALA n 
2 96  ARG n 
2 97  SER n 
2 98  LEU n 
2 99  GLU n 
2 100 GLU n 
2 101 PHE n 
2 102 ASN n 
2 103 ASP n 
2 104 VAL n 
2 105 TYR n 
2 106 LEU n 
2 107 VAL n 
2 108 THR n 
2 109 HIS n 
2 110 LEU n 
2 111 MET n 
2 112 GLY n 
2 113 ALA n 
2 114 ASP n 
2 115 LEU n 
2 116 ASN n 
2 117 ASN n 
2 118 ILE n 
2 119 VAL n 
2 120 LYS n 
2 121 CYS n 
2 122 GLN n 
2 123 LYS n 
2 124 LEU n 
2 125 THR n 
2 126 ASP n 
2 127 ASP n 
2 128 HIS n 
2 129 VAL n 
2 130 GLN n 
2 131 PHE n 
2 132 LEU n 
2 133 ILE n 
2 134 TYR n 
2 135 GLN n 
2 136 ILE n 
2 137 LEU n 
2 138 ARG n 
2 139 GLY n 
2 140 LEU n 
2 141 LYS n 
2 142 TYR n 
2 143 ILE n 
2 144 HIS n 
2 145 SER n 
2 146 ALA n 
2 147 ASP n 
2 148 ILE n 
2 149 ILE n 
2 150 HIS n 
2 151 ARG n 
2 152 ASP n 
2 153 LEU n 
2 154 LYS n 
2 155 PRO n 
2 156 SER n 
2 157 ASN n 
2 158 LEU n 
2 159 ALA n 
2 160 VAL n 
2 161 ASN n 
2 162 GLU n 
2 163 ASP n 
2 164 CYS n 
2 165 GLU n 
2 166 LEU n 
2 167 LYS n 
2 168 ILE n 
2 169 LEU n 
2 170 ASP n 
2 171 PHE n 
2 172 GLY n 
2 173 LEU n 
2 174 ALA n 
2 175 ARG n 
2 176 HIS n 
2 177 THR n 
2 178 ASP n 
2 179 ASP n 
2 180 GLU n 
2 181 MET n 
2 182 THR n 
2 183 GLY n 
2 184 TYR n 
2 185 VAL n 
2 186 ALA n 
2 187 THR n 
2 188 ARG n 
2 189 TRP n 
2 190 TYR n 
2 191 ARG n 
2 192 ALA n 
2 193 PRO n 
2 194 GLU n 
2 195 ILE n 
2 196 MET n 
2 197 LEU n 
2 198 ASN n 
2 199 TRP n 
2 200 MET n 
2 201 HIS n 
2 202 TYR n 
2 203 ASN n 
2 204 GLN n 
2 205 THR n 
2 206 VAL n 
2 207 ASP n 
2 208 ILE n 
2 209 TRP n 
2 210 SER n 
2 211 VAL n 
2 212 GLY n 
2 213 CYS n 
2 214 ILE n 
2 215 MET n 
2 216 ALA n 
2 217 GLU n 
2 218 LEU n 
2 219 LEU n 
2 220 THR n 
2 221 GLY n 
2 222 ARG n 
2 223 THR n 
2 224 LEU n 
2 225 PHE n 
2 226 PRO n 
2 227 GLY n 
2 228 THR n 
2 229 ASP n 
2 230 HIS n 
2 231 ILE n 
2 232 ASP n 
2 233 GLN n 
2 234 LEU n 
2 235 LYS n 
2 236 LEU n 
2 237 ILE n 
2 238 LEU n 
2 239 ARG n 
2 240 LEU n 
2 241 VAL n 
2 242 GLY n 
2 243 THR n 
2 244 PRO n 
2 245 GLY n 
2 246 ALA n 
2 247 GLU n 
2 248 LEU n 
2 249 LEU n 
2 250 LYS n 
2 251 LYS n 
2 252 ILE n 
2 253 SER n 
2 254 SER n 
2 255 GLU n 
2 256 SER n 
2 257 ALA n 
2 258 ARG n 
2 259 ASN n 
2 260 TYR n 
2 261 ILE n 
2 262 GLN n 
2 263 SER n 
2 264 LEU n 
2 265 ALA n 
2 266 GLN n 
2 267 MET n 
2 268 PRO n 
2 269 LYS n 
2 270 MET n 
2 271 ASN n 
2 272 PHE n 
2 273 ALA n 
2 274 ASN n 
2 275 VAL n 
2 276 PHE n 
2 277 ILE n 
2 278 GLY n 
2 279 ALA n 
2 280 ASN n 
2 281 PRO n 
2 282 LEU n 
2 283 ALA n 
2 284 VAL n 
2 285 ASP n 
2 286 LEU n 
2 287 LEU n 
2 288 GLU n 
2 289 LYS n 
2 290 MET n 
2 291 LEU n 
2 292 VAL n 
2 293 LEU n 
2 294 ASP n 
2 295 SER n 
2 296 ASP n 
2 297 LYS n 
2 298 ARG n 
2 299 ILE n 
2 300 THR n 
2 301 ALA n 
2 302 ALA n 
2 303 GLN n 
2 304 ALA n 
2 305 LEU n 
2 306 ALA n 
2 307 HIS n 
2 308 ALA n 
2 309 TYR n 
2 310 PHE n 
2 311 ALA n 
2 312 GLN n 
2 313 TYR n 
2 314 HIS n 
2 315 ASP n 
2 316 PRO n 
2 317 ASP n 
2 318 ASP n 
2 319 GLU n 
2 320 PRO n 
2 321 VAL n 
2 322 ALA n 
2 323 ASP n 
2 324 PRO n 
2 325 TYR n 
2 326 ASP n 
2 327 GLN n 
2 328 SER n 
2 329 PHE n 
2 330 GLU n 
2 331 SER n 
2 332 ARG n 
2 333 ASP n 
2 334 LEU n 
2 335 LEU n 
2 336 ILE n 
2 337 ASP n 
2 338 GLU n 
2 339 TRP n 
2 340 LYS n 
2 341 SER n 
2 342 LEU n 
2 343 THR n 
2 344 TYR n 
2 345 ASP n 
2 346 GLU n 
2 347 VAL n 
2 348 ILE n 
2 349 SER n 
2 350 PHE n 
2 351 VAL n 
2 352 PRO n 
2 353 PRO n 
2 354 PRO n 
2 355 LEU n 
2 356 ASP n 
2 357 GLN n 
2 358 GLU n 
2 359 GLU n 
2 360 MET n 
2 361 GLU n 
2 362 SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 35  human         ? 'ATF2, CREB2, CREBP1'        ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? 
? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 362 'house mouse' ? 'Mapk14, Crk1, Csbp1, Csbp2' ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? 
? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   46  ?   ?   ?   B . n 
A 1 2   HIS 2   47  ?   ?   ?   B . n 
A 1 3   LYS 3   48  ?   ?   ?   B . n 
A 1 4   HIS 4   49  ?   ?   ?   B . n 
A 1 5   GLU 5   50  50  GLU GLU B . n 
A 1 6   MET 6   51  51  MET MET B . n 
A 1 7   THR 7   52  52  THR THR B . n 
A 1 8   LEU 8   53  53  LEU LEU B . n 
A 1 9   LYS 9   54  54  LYS LYS B . n 
A 1 10  PHE 10  55  55  PHE PHE B . n 
A 1 11  GLY 11  56  56  GLY GLY B . n 
A 1 12  PRO 12  57  ?   ?   ?   B . n 
A 1 13  ALA 13  58  ?   ?   ?   B . n 
A 1 14  ARG 14  59  ?   ?   ?   B . n 
A 1 15  ASN 15  60  ?   ?   ?   B . n 
A 1 16  ASP 16  61  ?   ?   ?   B . n 
A 1 17  SER 17  62  ?   ?   ?   B . n 
A 1 18  VAL 18  63  ?   ?   ?   B . n 
A 1 19  ILE 19  64  ?   ?   ?   B . n 
A 1 20  VAL 20  65  ?   ?   ?   B . n 
A 1 21  ALA 21  66  ?   ?   ?   B . n 
A 1 22  ASP 22  67  ?   ?   ?   B . n 
A 1 23  GLN 23  68  ?   ?   ?   B . n 
A 1 24  THR 24  69  ?   ?   ?   B . n 
A 1 25  PRO 25  70  ?   ?   ?   B . n 
A 1 26  THR 26  71  ?   ?   ?   B . n 
A 1 27  PRO 27  72  ?   ?   ?   B . n 
A 1 28  THR 28  73  ?   ?   ?   B . n 
A 1 29  ARG 29  74  ?   ?   ?   B . n 
A 1 30  PHE 30  75  ?   ?   ?   B . n 
A 1 31  LEU 31  76  ?   ?   ?   B . n 
A 1 32  LYS 32  77  ?   ?   ?   B . n 
A 1 33  ASN 33  78  ?   ?   ?   B . n 
A 1 34  CYS 34  79  ?   ?   ?   B . n 
A 1 35  GLU 35  80  ?   ?   ?   B . n 
B 2 1   VAL 1   -1  -1  VAL VAL A . n 
B 2 2   HIS 2   0   0   HIS HIS A . n 
B 2 3   MET 3   1   1   MET MET A . n 
B 2 4   SER 4   2   2   SER SER A . n 
B 2 5   GLN 5   3   3   GLN GLN A . n 
B 2 6   GLU 6   4   4   GLU GLU A . n 
B 2 7   ARG 7   5   5   ARG ARG A . n 
B 2 8   PRO 8   6   6   PRO PRO A . n 
B 2 9   THR 9   7   7   THR THR A . n 
B 2 10  PHE 10  8   8   PHE PHE A . n 
B 2 11  TYR 11  9   9   TYR TYR A . n 
B 2 12  ARG 12  10  10  ARG ARG A . n 
B 2 13  GLN 13  11  11  GLN GLN A . n 
B 2 14  GLU 14  12  12  GLU GLU A . n 
B 2 15  LEU 15  13  13  LEU LEU A . n 
B 2 16  ASN 16  14  14  ASN ASN A . n 
B 2 17  LYS 17  15  15  LYS LYS A . n 
B 2 18  THR 18  16  16  THR THR A . n 
B 2 19  ILE 19  17  17  ILE ILE A . n 
B 2 20  TRP 20  18  18  TRP TRP A . n 
B 2 21  GLU 21  19  19  GLU GLU A . n 
B 2 22  VAL 22  20  20  VAL VAL A . n 
B 2 23  PRO 23  21  21  PRO PRO A . n 
B 2 24  GLU 24  22  22  GLU GLU A . n 
B 2 25  ARG 25  23  23  ARG ARG A . n 
B 2 26  TYR 26  24  24  TYR TYR A . n 
B 2 27  GLN 27  25  25  GLN GLN A . n 
B 2 28  ASN 28  26  26  ASN ASN A . n 
B 2 29  LEU 29  27  27  LEU LEU A . n 
B 2 30  SER 30  28  28  SER SER A . n 
B 2 31  PRO 31  29  29  PRO PRO A . n 
B 2 32  VAL 32  30  30  VAL VAL A . n 
B 2 33  GLY 33  31  31  GLY GLY A . n 
B 2 34  SER 34  32  32  SER SER A . n 
B 2 35  GLY 35  33  33  GLY GLY A . n 
B 2 36  ALA 36  34  34  ALA ALA A . n 
B 2 37  TYR 37  35  35  TYR TYR A . n 
B 2 38  GLY 38  36  36  GLY GLY A . n 
B 2 39  SER 39  37  37  SER SER A . n 
B 2 40  VAL 40  38  38  VAL VAL A . n 
B 2 41  CYS 41  39  39  CYS CYS A . n 
B 2 42  ALA 42  40  40  ALA ALA A . n 
B 2 43  ALA 43  41  41  ALA ALA A . n 
B 2 44  PHE 44  42  42  PHE PHE A . n 
B 2 45  ASP 45  43  43  ASP ASP A . n 
B 2 46  THR 46  44  44  THR THR A . n 
B 2 47  LYS 47  45  45  LYS LYS A . n 
B 2 48  THR 48  46  46  THR THR A . n 
B 2 49  GLY 49  47  47  GLY GLY A . n 
B 2 50  HIS 50  48  48  HIS HIS A . n 
B 2 51  ARG 51  49  49  ARG ARG A . n 
B 2 52  VAL 52  50  50  VAL VAL A . n 
B 2 53  ALA 53  51  51  ALA ALA A . n 
B 2 54  VAL 54  52  52  VAL VAL A . n 
B 2 55  LYS 55  53  53  LYS LYS A . n 
B 2 56  LYS 56  54  54  LYS LYS A . n 
B 2 57  LEU 57  55  55  LEU LEU A . n 
B 2 58  SER 58  56  56  SER SER A . n 
B 2 59  ARG 59  57  57  ARG ARG A . n 
B 2 60  PRO 60  58  58  PRO PRO A . n 
B 2 61  PHE 61  59  59  PHE PHE A . n 
B 2 62  GLN 62  60  60  GLN GLN A . n 
B 2 63  SER 63  61  61  SER SER A . n 
B 2 64  ILE 64  62  62  ILE ILE A . n 
B 2 65  ILE 65  63  63  ILE ILE A . n 
B 2 66  HIS 66  64  64  HIS HIS A . n 
B 2 67  ALA 67  65  65  ALA ALA A . n 
B 2 68  LYS 68  66  66  LYS LYS A . n 
B 2 69  ARG 69  67  67  ARG ARG A . n 
B 2 70  THR 70  68  68  THR THR A . n 
B 2 71  TYR 71  69  69  TYR TYR A . n 
B 2 72  ARG 72  70  70  ARG ARG A . n 
B 2 73  GLU 73  71  71  GLU GLU A . n 
B 2 74  LEU 74  72  72  LEU LEU A . n 
B 2 75  ARG 75  73  73  ARG ARG A . n 
B 2 76  LEU 76  74  74  LEU LEU A . n 
B 2 77  LEU 77  75  75  LEU LEU A . n 
B 2 78  LYS 78  76  76  LYS LYS A . n 
B 2 79  HIS 79  77  77  HIS HIS A . n 
B 2 80  MET 80  78  78  MET MET A . n 
B 2 81  LYS 81  79  79  LYS LYS A . n 
B 2 82  HIS 82  80  80  HIS HIS A . n 
B 2 83  GLU 83  81  81  GLU GLU A . n 
B 2 84  ASN 84  82  82  ASN ASN A . n 
B 2 85  VAL 85  83  83  VAL VAL A . n 
B 2 86  ILE 86  84  84  ILE ILE A . n 
B 2 87  GLY 87  85  85  GLY GLY A . n 
B 2 88  LEU 88  86  86  LEU LEU A . n 
B 2 89  LEU 89  87  87  LEU LEU A . n 
B 2 90  ASP 90  88  88  ASP ASP A . n 
B 2 91  VAL 91  89  89  VAL VAL A . n 
B 2 92  PHE 92  90  90  PHE PHE A . n 
B 2 93  THR 93  91  91  THR THR A . n 
B 2 94  PRO 94  92  92  PRO PRO A . n 
B 2 95  ALA 95  93  93  ALA ALA A . n 
B 2 96  ARG 96  94  94  ARG ARG A . n 
B 2 97  SER 97  95  95  SER SER A . n 
B 2 98  LEU 98  96  96  LEU LEU A . n 
B 2 99  GLU 99  97  97  GLU GLU A . n 
B 2 100 GLU 100 98  98  GLU GLU A . n 
B 2 101 PHE 101 99  99  PHE PHE A . n 
B 2 102 ASN 102 100 100 ASN ASN A . n 
B 2 103 ASP 103 101 101 ASP ASP A . n 
B 2 104 VAL 104 102 102 VAL VAL A . n 
B 2 105 TYR 105 103 103 TYR TYR A . n 
B 2 106 LEU 106 104 104 LEU LEU A . n 
B 2 107 VAL 107 105 105 VAL VAL A . n 
B 2 108 THR 108 106 106 THR THR A . n 
B 2 109 HIS 109 107 107 HIS HIS A . n 
B 2 110 LEU 110 108 108 LEU LEU A . n 
B 2 111 MET 111 109 109 MET MET A . n 
B 2 112 GLY 112 110 110 GLY GLY A . n 
B 2 113 ALA 113 111 111 ALA ALA A . n 
B 2 114 ASP 114 112 112 ASP ASP A . n 
B 2 115 LEU 115 113 113 LEU LEU A . n 
B 2 116 ASN 116 114 114 ASN ASN A . n 
B 2 117 ASN 117 115 115 ASN ASN A . n 
B 2 118 ILE 118 116 116 ILE ILE A . n 
B 2 119 VAL 119 117 117 VAL VAL A . n 
B 2 120 LYS 120 118 118 LYS LYS A . n 
B 2 121 CYS 121 119 119 CYS CYS A . n 
B 2 122 GLN 122 120 120 GLN GLN A . n 
B 2 123 LYS 123 121 121 LYS LYS A . n 
B 2 124 LEU 124 122 122 LEU LEU A . n 
B 2 125 THR 125 123 123 THR THR A . n 
B 2 126 ASP 126 124 124 ASP ASP A . n 
B 2 127 ASP 127 125 125 ASP ASP A . n 
B 2 128 HIS 128 126 126 HIS HIS A . n 
B 2 129 VAL 129 127 127 VAL VAL A . n 
B 2 130 GLN 130 128 128 GLN GLN A . n 
B 2 131 PHE 131 129 129 PHE PHE A . n 
B 2 132 LEU 132 130 130 LEU LEU A . n 
B 2 133 ILE 133 131 131 ILE ILE A . n 
B 2 134 TYR 134 132 132 TYR TYR A . n 
B 2 135 GLN 135 133 133 GLN GLN A . n 
B 2 136 ILE 136 134 134 ILE ILE A . n 
B 2 137 LEU 137 135 135 LEU LEU A . n 
B 2 138 ARG 138 136 136 ARG ARG A . n 
B 2 139 GLY 139 137 137 GLY GLY A . n 
B 2 140 LEU 140 138 138 LEU LEU A . n 
B 2 141 LYS 141 139 139 LYS LYS A . n 
B 2 142 TYR 142 140 140 TYR TYR A . n 
B 2 143 ILE 143 141 141 ILE ILE A . n 
B 2 144 HIS 144 142 142 HIS HIS A . n 
B 2 145 SER 145 143 143 SER SER A . n 
B 2 146 ALA 146 144 144 ALA ALA A . n 
B 2 147 ASP 147 145 145 ASP ASP A . n 
B 2 148 ILE 148 146 146 ILE ILE A . n 
B 2 149 ILE 149 147 147 ILE ILE A . n 
B 2 150 HIS 150 148 148 HIS HIS A . n 
B 2 151 ARG 151 149 149 ARG ARG A . n 
B 2 152 ASP 152 150 150 ASP ASP A . n 
B 2 153 LEU 153 151 151 LEU LEU A . n 
B 2 154 LYS 154 152 152 LYS LYS A . n 
B 2 155 PRO 155 153 153 PRO PRO A . n 
B 2 156 SER 156 154 154 SER SER A . n 
B 2 157 ASN 157 155 155 ASN ASN A . n 
B 2 158 LEU 158 156 156 LEU LEU A . n 
B 2 159 ALA 159 157 157 ALA ALA A . n 
B 2 160 VAL 160 158 158 VAL VAL A . n 
B 2 161 ASN 161 159 159 ASN ASN A . n 
B 2 162 GLU 162 160 160 GLU GLU A . n 
B 2 163 ASP 163 161 161 ASP ASP A . n 
B 2 164 CYS 164 162 162 CYS CYS A . n 
B 2 165 GLU 165 163 163 GLU GLU A . n 
B 2 166 LEU 166 164 164 LEU LEU A . n 
B 2 167 LYS 167 165 165 LYS LYS A . n 
B 2 168 ILE 168 166 166 ILE ILE A . n 
B 2 169 LEU 169 167 167 LEU LEU A . n 
B 2 170 ASP 170 168 168 ASP ASP A . n 
B 2 171 PHE 171 169 169 PHE PHE A . n 
B 2 172 GLY 172 170 170 GLY GLY A . n 
B 2 173 LEU 173 171 171 LEU LEU A . n 
B 2 174 ALA 174 172 172 ALA ALA A . n 
B 2 175 ARG 175 173 ?   ?   ?   A . n 
B 2 176 HIS 176 174 ?   ?   ?   A . n 
B 2 177 THR 177 175 ?   ?   ?   A . n 
B 2 178 ASP 178 176 ?   ?   ?   A . n 
B 2 179 ASP 179 177 ?   ?   ?   A . n 
B 2 180 GLU 180 178 ?   ?   ?   A . n 
B 2 181 MET 181 179 ?   ?   ?   A . n 
B 2 182 THR 182 180 ?   ?   ?   A . n 
B 2 183 GLY 183 181 ?   ?   ?   A . n 
B 2 184 TYR 184 182 ?   ?   ?   A . n 
B 2 185 VAL 185 183 ?   ?   ?   A . n 
B 2 186 ALA 186 184 184 ALA ALA A . n 
B 2 187 THR 187 185 185 THR THR A . n 
B 2 188 ARG 188 186 186 ARG ARG A . n 
B 2 189 TRP 189 187 187 TRP TRP A . n 
B 2 190 TYR 190 188 188 TYR TYR A . n 
B 2 191 ARG 191 189 189 ARG ARG A . n 
B 2 192 ALA 192 190 190 ALA ALA A . n 
B 2 193 PRO 193 191 191 PRO PRO A . n 
B 2 194 GLU 194 192 192 GLU GLU A . n 
B 2 195 ILE 195 193 193 ILE ILE A . n 
B 2 196 MET 196 194 194 MET MET A . n 
B 2 197 LEU 197 195 195 LEU LEU A . n 
B 2 198 ASN 198 196 196 ASN ASN A . n 
B 2 199 TRP 199 197 197 TRP TRP A . n 
B 2 200 MET 200 198 198 MET MET A . n 
B 2 201 HIS 201 199 199 HIS HIS A . n 
B 2 202 TYR 202 200 200 TYR TYR A . n 
B 2 203 ASN 203 201 201 ASN ASN A . n 
B 2 204 GLN 204 202 202 GLN GLN A . n 
B 2 205 THR 205 203 203 THR THR A . n 
B 2 206 VAL 206 204 204 VAL VAL A . n 
B 2 207 ASP 207 205 205 ASP ASP A . n 
B 2 208 ILE 208 206 206 ILE ILE A . n 
B 2 209 TRP 209 207 207 TRP TRP A . n 
B 2 210 SER 210 208 208 SER SER A . n 
B 2 211 VAL 211 209 209 VAL VAL A . n 
B 2 212 GLY 212 210 210 GLY GLY A . n 
B 2 213 CYS 213 211 211 CYS CYS A . n 
B 2 214 ILE 214 212 212 ILE ILE A . n 
B 2 215 MET 215 213 213 MET MET A . n 
B 2 216 ALA 216 214 214 ALA ALA A . n 
B 2 217 GLU 217 215 215 GLU GLU A . n 
B 2 218 LEU 218 216 216 LEU LEU A . n 
B 2 219 LEU 219 217 217 LEU LEU A . n 
B 2 220 THR 220 218 218 THR THR A . n 
B 2 221 GLY 221 219 219 GLY GLY A . n 
B 2 222 ARG 222 220 220 ARG ARG A . n 
B 2 223 THR 223 221 221 THR THR A . n 
B 2 224 LEU 224 222 222 LEU LEU A . n 
B 2 225 PHE 225 223 223 PHE PHE A . n 
B 2 226 PRO 226 224 224 PRO PRO A . n 
B 2 227 GLY 227 225 225 GLY GLY A . n 
B 2 228 THR 228 226 226 THR THR A . n 
B 2 229 ASP 229 227 227 ASP ASP A . n 
B 2 230 HIS 230 228 228 HIS HIS A . n 
B 2 231 ILE 231 229 229 ILE ILE A . n 
B 2 232 ASP 232 230 230 ASP ASP A . n 
B 2 233 GLN 233 231 231 GLN GLN A . n 
B 2 234 LEU 234 232 232 LEU LEU A . n 
B 2 235 LYS 235 233 233 LYS LYS A . n 
B 2 236 LEU 236 234 234 LEU LEU A . n 
B 2 237 ILE 237 235 235 ILE ILE A . n 
B 2 238 LEU 238 236 236 LEU LEU A . n 
B 2 239 ARG 239 237 237 ARG ARG A . n 
B 2 240 LEU 240 238 238 LEU LEU A . n 
B 2 241 VAL 241 239 239 VAL VAL A . n 
B 2 242 GLY 242 240 240 GLY GLY A . n 
B 2 243 THR 243 241 241 THR THR A . n 
B 2 244 PRO 244 242 242 PRO PRO A . n 
B 2 245 GLY 245 243 243 GLY GLY A . n 
B 2 246 ALA 246 244 244 ALA ALA A . n 
B 2 247 GLU 247 245 245 GLU GLU A . n 
B 2 248 LEU 248 246 246 LEU LEU A . n 
B 2 249 LEU 249 247 247 LEU LEU A . n 
B 2 250 LYS 250 248 248 LYS LYS A . n 
B 2 251 LYS 251 249 249 LYS LYS A . n 
B 2 252 ILE 252 250 250 ILE ILE A . n 
B 2 253 SER 253 251 251 SER SER A . n 
B 2 254 SER 254 252 252 SER SER A . n 
B 2 255 GLU 255 253 253 GLU GLU A . n 
B 2 256 SER 256 254 254 SER SER A . n 
B 2 257 ALA 257 255 255 ALA ALA A . n 
B 2 258 ARG 258 256 256 ARG ARG A . n 
B 2 259 ASN 259 257 257 ASN ASN A . n 
B 2 260 TYR 260 258 258 TYR TYR A . n 
B 2 261 ILE 261 259 259 ILE ILE A . n 
B 2 262 GLN 262 260 260 GLN GLN A . n 
B 2 263 SER 263 261 261 SER SER A . n 
B 2 264 LEU 264 262 262 LEU LEU A . n 
B 2 265 ALA 265 263 263 ALA ALA A . n 
B 2 266 GLN 266 264 264 GLN GLN A . n 
B 2 267 MET 267 265 265 MET MET A . n 
B 2 268 PRO 268 266 266 PRO PRO A . n 
B 2 269 LYS 269 267 267 LYS LYS A . n 
B 2 270 MET 270 268 268 MET MET A . n 
B 2 271 ASN 271 269 269 ASN ASN A . n 
B 2 272 PHE 272 270 270 PHE PHE A . n 
B 2 273 ALA 273 271 271 ALA ALA A . n 
B 2 274 ASN 274 272 272 ASN ASN A . n 
B 2 275 VAL 275 273 273 VAL VAL A . n 
B 2 276 PHE 276 274 274 PHE PHE A . n 
B 2 277 ILE 277 275 275 ILE ILE A . n 
B 2 278 GLY 278 276 276 GLY GLY A . n 
B 2 279 ALA 279 277 277 ALA ALA A . n 
B 2 280 ASN 280 278 278 ASN ASN A . n 
B 2 281 PRO 281 279 279 PRO PRO A . n 
B 2 282 LEU 282 280 280 LEU LEU A . n 
B 2 283 ALA 283 281 281 ALA ALA A . n 
B 2 284 VAL 284 282 282 VAL VAL A . n 
B 2 285 ASP 285 283 283 ASP ASP A . n 
B 2 286 LEU 286 284 284 LEU LEU A . n 
B 2 287 LEU 287 285 285 LEU LEU A . n 
B 2 288 GLU 288 286 286 GLU GLU A . n 
B 2 289 LYS 289 287 287 LYS LYS A . n 
B 2 290 MET 290 288 288 MET MET A . n 
B 2 291 LEU 291 289 289 LEU LEU A . n 
B 2 292 VAL 292 290 290 VAL VAL A . n 
B 2 293 LEU 293 291 291 LEU LEU A . n 
B 2 294 ASP 294 292 292 ASP ASP A . n 
B 2 295 SER 295 293 293 SER SER A . n 
B 2 296 ASP 296 294 294 ASP ASP A . n 
B 2 297 LYS 297 295 295 LYS LYS A . n 
B 2 298 ARG 298 296 296 ARG ARG A . n 
B 2 299 ILE 299 297 297 ILE ILE A . n 
B 2 300 THR 300 298 298 THR THR A . n 
B 2 301 ALA 301 299 299 ALA ALA A . n 
B 2 302 ALA 302 300 300 ALA ALA A . n 
B 2 303 GLN 303 301 301 GLN GLN A . n 
B 2 304 ALA 304 302 302 ALA ALA A . n 
B 2 305 LEU 305 303 303 LEU LEU A . n 
B 2 306 ALA 306 304 304 ALA ALA A . n 
B 2 307 HIS 307 305 305 HIS HIS A . n 
B 2 308 ALA 308 306 306 ALA ALA A . n 
B 2 309 TYR 309 307 307 TYR TYR A . n 
B 2 310 PHE 310 308 308 PHE PHE A . n 
B 2 311 ALA 311 309 309 ALA ALA A . n 
B 2 312 GLN 312 310 310 GLN GLN A . n 
B 2 313 TYR 313 311 311 TYR TYR A . n 
B 2 314 HIS 314 312 312 HIS HIS A . n 
B 2 315 ASP 315 313 313 ASP ASP A . n 
B 2 316 PRO 316 314 314 PRO PRO A . n 
B 2 317 ASP 317 315 315 ASP ASP A . n 
B 2 318 ASP 318 316 316 ASP ASP A . n 
B 2 319 GLU 319 317 317 GLU GLU A . n 
B 2 320 PRO 320 318 318 PRO PRO A . n 
B 2 321 VAL 321 319 319 VAL VAL A . n 
B 2 322 ALA 322 320 320 ALA ALA A . n 
B 2 323 ASP 323 321 321 ASP ASP A . n 
B 2 324 PRO 324 322 322 PRO PRO A . n 
B 2 325 TYR 325 323 323 TYR TYR A . n 
B 2 326 ASP 326 324 324 ASP ASP A . n 
B 2 327 GLN 327 325 325 GLN GLN A . n 
B 2 328 SER 328 326 326 SER SER A . n 
B 2 329 PHE 329 327 327 PHE PHE A . n 
B 2 330 GLU 330 328 328 GLU GLU A . n 
B 2 331 SER 331 329 329 SER SER A . n 
B 2 332 ARG 332 330 330 ARG ARG A . n 
B 2 333 ASP 333 331 331 ASP ASP A . n 
B 2 334 LEU 334 332 332 LEU LEU A . n 
B 2 335 LEU 335 333 333 LEU LEU A . n 
B 2 336 ILE 336 334 334 ILE ILE A . n 
B 2 337 ASP 337 335 335 ASP ASP A . n 
B 2 338 GLU 338 336 336 GLU GLU A . n 
B 2 339 TRP 339 337 337 TRP TRP A . n 
B 2 340 LYS 340 338 338 LYS LYS A . n 
B 2 341 SER 341 339 339 SER SER A . n 
B 2 342 LEU 342 340 340 LEU LEU A . n 
B 2 343 THR 343 341 341 THR THR A . n 
B 2 344 TYR 344 342 342 TYR TYR A . n 
B 2 345 ASP 345 343 343 ASP ASP A . n 
B 2 346 GLU 346 344 344 GLU GLU A . n 
B 2 347 VAL 347 345 345 VAL VAL A . n 
B 2 348 ILE 348 346 346 ILE ILE A . n 
B 2 349 SER 349 347 347 SER SER A . n 
B 2 350 PHE 350 348 348 PHE PHE A . n 
B 2 351 VAL 351 349 349 VAL VAL A . n 
B 2 352 PRO 352 350 350 PRO PRO A . n 
B 2 353 PRO 353 351 351 PRO PRO A . n 
B 2 354 PRO 354 352 352 PRO PRO A . n 
B 2 355 LEU 355 353 353 LEU LEU A . n 
B 2 356 ASP 356 354 ?   ?   ?   A . n 
B 2 357 GLN 357 355 ?   ?   ?   A . n 
B 2 358 GLU 358 356 ?   ?   ?   A . n 
B 2 359 GLU 359 357 ?   ?   ?   A . n 
B 2 360 MET 360 358 ?   ?   ?   A . n 
B 2 361 GLU 361 359 ?   ?   ?   A . n 
B 2 362 SER 362 360 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   101 145 HOH HOH B . 
C 3 HOH 2   102 266 HOH HOH B . 
C 3 HOH 3   103 278 HOH HOH B . 
C 3 HOH 4   104 299 HOH HOH B . 
C 3 HOH 5   105 227 HOH HOH B . 
C 3 HOH 6   106 39  HOH HOH B . 
C 3 HOH 7   107 267 HOH HOH B . 
D 3 HOH 1   401 121 HOH HOH A . 
D 3 HOH 2   402 42  HOH HOH A . 
D 3 HOH 3   403 80  HOH HOH A . 
D 3 HOH 4   404 177 HOH HOH A . 
D 3 HOH 5   405 224 HOH HOH A . 
D 3 HOH 6   406 242 HOH HOH A . 
D 3 HOH 7   407 244 HOH HOH A . 
D 3 HOH 8   408 300 HOH HOH A . 
D 3 HOH 9   409 252 HOH HOH A . 
D 3 HOH 10  410 218 HOH HOH A . 
D 3 HOH 11  411 46  HOH HOH A . 
D 3 HOH 12  412 208 HOH HOH A . 
D 3 HOH 13  413 22  HOH HOH A . 
D 3 HOH 14  414 68  HOH HOH A . 
D 3 HOH 15  415 138 HOH HOH A . 
D 3 HOH 16  416 217 HOH HOH A . 
D 3 HOH 17  417 78  HOH HOH A . 
D 3 HOH 18  418 94  HOH HOH A . 
D 3 HOH 19  419 44  HOH HOH A . 
D 3 HOH 20  420 77  HOH HOH A . 
D 3 HOH 21  421 186 HOH HOH A . 
D 3 HOH 22  422 133 HOH HOH A . 
D 3 HOH 23  423 25  HOH HOH A . 
D 3 HOH 24  424 20  HOH HOH A . 
D 3 HOH 25  425 101 HOH HOH A . 
D 3 HOH 26  426 45  HOH HOH A . 
D 3 HOH 27  427 98  HOH HOH A . 
D 3 HOH 28  428 6   HOH HOH A . 
D 3 HOH 29  429 97  HOH HOH A . 
D 3 HOH 30  430 130 HOH HOH A . 
D 3 HOH 31  431 206 HOH HOH A . 
D 3 HOH 32  432 110 HOH HOH A . 
D 3 HOH 33  433 135 HOH HOH A . 
D 3 HOH 34  434 193 HOH HOH A . 
D 3 HOH 35  435 56  HOH HOH A . 
D 3 HOH 36  436 65  HOH HOH A . 
D 3 HOH 37  437 184 HOH HOH A . 
D 3 HOH 38  438 265 HOH HOH A . 
D 3 HOH 39  439 167 HOH HOH A . 
D 3 HOH 40  440 119 HOH HOH A . 
D 3 HOH 41  441 21  HOH HOH A . 
D 3 HOH 42  442 38  HOH HOH A . 
D 3 HOH 43  443 251 HOH HOH A . 
D 3 HOH 44  444 214 HOH HOH A . 
D 3 HOH 45  445 33  HOH HOH A . 
D 3 HOH 46  446 127 HOH HOH A . 
D 3 HOH 47  447 74  HOH HOH A . 
D 3 HOH 48  448 198 HOH HOH A . 
D 3 HOH 49  449 41  HOH HOH A . 
D 3 HOH 50  450 125 HOH HOH A . 
D 3 HOH 51  451 76  HOH HOH A . 
D 3 HOH 52  452 291 HOH HOH A . 
D 3 HOH 53  453 183 HOH HOH A . 
D 3 HOH 54  454 147 HOH HOH A . 
D 3 HOH 55  455 223 HOH HOH A . 
D 3 HOH 56  456 179 HOH HOH A . 
D 3 HOH 57  457 9   HOH HOH A . 
D 3 HOH 58  458 241 HOH HOH A . 
D 3 HOH 59  459 293 HOH HOH A . 
D 3 HOH 60  460 116 HOH HOH A . 
D 3 HOH 61  461 29  HOH HOH A . 
D 3 HOH 62  462 159 HOH HOH A . 
D 3 HOH 63  463 96  HOH HOH A . 
D 3 HOH 64  464 53  HOH HOH A . 
D 3 HOH 65  465 4   HOH HOH A . 
D 3 HOH 66  466 73  HOH HOH A . 
D 3 HOH 67  467 225 HOH HOH A . 
D 3 HOH 68  468 66  HOH HOH A . 
D 3 HOH 69  469 11  HOH HOH A . 
D 3 HOH 70  470 205 HOH HOH A . 
D 3 HOH 71  471 117 HOH HOH A . 
D 3 HOH 72  472 16  HOH HOH A . 
D 3 HOH 73  473 132 HOH HOH A . 
D 3 HOH 74  474 140 HOH HOH A . 
D 3 HOH 75  475 235 HOH HOH A . 
D 3 HOH 76  476 195 HOH HOH A . 
D 3 HOH 77  477 69  HOH HOH A . 
D 3 HOH 78  478 146 HOH HOH A . 
D 3 HOH 79  479 144 HOH HOH A . 
D 3 HOH 80  480 163 HOH HOH A . 
D 3 HOH 81  481 109 HOH HOH A . 
D 3 HOH 82  482 271 HOH HOH A . 
D 3 HOH 83  483 58  HOH HOH A . 
D 3 HOH 84  484 62  HOH HOH A . 
D 3 HOH 85  485 172 HOH HOH A . 
D 3 HOH 86  486 30  HOH HOH A . 
D 3 HOH 87  487 188 HOH HOH A . 
D 3 HOH 88  488 43  HOH HOH A . 
D 3 HOH 89  489 86  HOH HOH A . 
D 3 HOH 90  490 92  HOH HOH A . 
D 3 HOH 91  491 103 HOH HOH A . 
D 3 HOH 92  492 289 HOH HOH A . 
D 3 HOH 93  493 274 HOH HOH A . 
D 3 HOH 94  494 60  HOH HOH A . 
D 3 HOH 95  495 148 HOH HOH A . 
D 3 HOH 96  496 168 HOH HOH A . 
D 3 HOH 97  497 295 HOH HOH A . 
D 3 HOH 98  498 123 HOH HOH A . 
D 3 HOH 99  499 10  HOH HOH A . 
D 3 HOH 100 500 105 HOH HOH A . 
D 3 HOH 101 501 52  HOH HOH A . 
D 3 HOH 102 502 1   HOH HOH A . 
D 3 HOH 103 503 156 HOH HOH A . 
D 3 HOH 104 504 85  HOH HOH A . 
D 3 HOH 105 505 70  HOH HOH A . 
D 3 HOH 106 506 134 HOH HOH A . 
D 3 HOH 107 507 272 HOH HOH A . 
D 3 HOH 108 508 40  HOH HOH A . 
D 3 HOH 109 509 23  HOH HOH A . 
D 3 HOH 110 510 75  HOH HOH A . 
D 3 HOH 111 511 81  HOH HOH A . 
D 3 HOH 112 512 47  HOH HOH A . 
D 3 HOH 113 513 2   HOH HOH A . 
D 3 HOH 114 514 104 HOH HOH A . 
D 3 HOH 115 515 158 HOH HOH A . 
D 3 HOH 116 516 189 HOH HOH A . 
D 3 HOH 117 517 162 HOH HOH A . 
D 3 HOH 118 518 169 HOH HOH A . 
D 3 HOH 119 519 90  HOH HOH A . 
D 3 HOH 120 520 7   HOH HOH A . 
D 3 HOH 121 521 26  HOH HOH A . 
D 3 HOH 122 522 108 HOH HOH A . 
D 3 HOH 123 523 72  HOH HOH A . 
D 3 HOH 124 524 157 HOH HOH A . 
D 3 HOH 125 525 120 HOH HOH A . 
D 3 HOH 126 526 254 HOH HOH A . 
D 3 HOH 127 527 89  HOH HOH A . 
D 3 HOH 128 528 88  HOH HOH A . 
D 3 HOH 129 529 64  HOH HOH A . 
D 3 HOH 130 530 102 HOH HOH A . 
D 3 HOH 131 531 17  HOH HOH A . 
D 3 HOH 132 532 253 HOH HOH A . 
D 3 HOH 133 533 259 HOH HOH A . 
D 3 HOH 134 534 36  HOH HOH A . 
D 3 HOH 135 535 18  HOH HOH A . 
D 3 HOH 136 536 3   HOH HOH A . 
D 3 HOH 137 537 201 HOH HOH A . 
D 3 HOH 138 538 197 HOH HOH A . 
D 3 HOH 139 539 285 HOH HOH A . 
D 3 HOH 140 540 115 HOH HOH A . 
D 3 HOH 141 541 124 HOH HOH A . 
D 3 HOH 142 542 49  HOH HOH A . 
D 3 HOH 143 543 250 HOH HOH A . 
D 3 HOH 144 544 34  HOH HOH A . 
D 3 HOH 145 545 204 HOH HOH A . 
D 3 HOH 146 546 112 HOH HOH A . 
D 3 HOH 147 547 141 HOH HOH A . 
D 3 HOH 148 548 292 HOH HOH A . 
D 3 HOH 149 549 61  HOH HOH A . 
D 3 HOH 150 550 255 HOH HOH A . 
D 3 HOH 151 551 118 HOH HOH A . 
D 3 HOH 152 552 122 HOH HOH A . 
D 3 HOH 153 553 137 HOH HOH A . 
D 3 HOH 154 554 48  HOH HOH A . 
D 3 HOH 155 555 234 HOH HOH A . 
D 3 HOH 156 556 281 HOH HOH A . 
D 3 HOH 157 557 12  HOH HOH A . 
D 3 HOH 158 558 207 HOH HOH A . 
D 3 HOH 159 559 15  HOH HOH A . 
D 3 HOH 160 560 95  HOH HOH A . 
D 3 HOH 161 561 284 HOH HOH A . 
D 3 HOH 162 562 19  HOH HOH A . 
D 3 HOH 163 563 256 HOH HOH A . 
D 3 HOH 164 564 161 HOH HOH A . 
D 3 HOH 165 565 276 HOH HOH A . 
D 3 HOH 166 566 180 HOH HOH A . 
D 3 HOH 167 567 233 HOH HOH A . 
D 3 HOH 168 568 93  HOH HOH A . 
D 3 HOH 169 569 114 HOH HOH A . 
D 3 HOH 170 570 268 HOH HOH A . 
D 3 HOH 171 571 150 HOH HOH A . 
D 3 HOH 172 572 13  HOH HOH A . 
D 3 HOH 173 573 54  HOH HOH A . 
D 3 HOH 174 574 107 HOH HOH A . 
D 3 HOH 175 575 160 HOH HOH A . 
D 3 HOH 176 576 126 HOH HOH A . 
D 3 HOH 177 577 57  HOH HOH A . 
D 3 HOH 178 578 202 HOH HOH A . 
D 3 HOH 179 579 8   HOH HOH A . 
D 3 HOH 180 580 190 HOH HOH A . 
D 3 HOH 181 581 290 HOH HOH A . 
D 3 HOH 182 582 257 HOH HOH A . 
D 3 HOH 183 583 106 HOH HOH A . 
D 3 HOH 184 584 51  HOH HOH A . 
D 3 HOH 185 585 32  HOH HOH A . 
D 3 HOH 186 586 143 HOH HOH A . 
D 3 HOH 187 587 55  HOH HOH A . 
D 3 HOH 188 588 298 HOH HOH A . 
D 3 HOH 189 589 67  HOH HOH A . 
D 3 HOH 190 590 200 HOH HOH A . 
D 3 HOH 191 591 50  HOH HOH A . 
D 3 HOH 192 592 213 HOH HOH A . 
D 3 HOH 193 593 113 HOH HOH A . 
D 3 HOH 194 594 178 HOH HOH A . 
D 3 HOH 195 595 209 HOH HOH A . 
D 3 HOH 196 596 14  HOH HOH A . 
D 3 HOH 197 597 270 HOH HOH A . 
D 3 HOH 198 598 219 HOH HOH A . 
D 3 HOH 199 599 155 HOH HOH A . 
D 3 HOH 200 600 63  HOH HOH A . 
D 3 HOH 201 601 277 HOH HOH A . 
D 3 HOH 202 602 111 HOH HOH A . 
D 3 HOH 203 603 176 HOH HOH A . 
D 3 HOH 204 604 5   HOH HOH A . 
D 3 HOH 205 605 99  HOH HOH A . 
D 3 HOH 206 606 283 HOH HOH A . 
D 3 HOH 207 607 79  HOH HOH A . 
D 3 HOH 208 608 35  HOH HOH A . 
D 3 HOH 209 609 282 HOH HOH A . 
D 3 HOH 210 610 231 HOH HOH A . 
D 3 HOH 211 611 238 HOH HOH A . 
D 3 HOH 212 612 24  HOH HOH A . 
D 3 HOH 213 613 27  HOH HOH A . 
D 3 HOH 214 614 82  HOH HOH A . 
D 3 HOH 215 615 83  HOH HOH A . 
D 3 HOH 216 616 100 HOH HOH A . 
D 3 HOH 217 617 166 HOH HOH A . 
D 3 HOH 218 618 302 HOH HOH A . 
D 3 HOH 219 619 149 HOH HOH A . 
D 3 HOH 220 620 239 HOH HOH A . 
D 3 HOH 221 621 136 HOH HOH A . 
D 3 HOH 222 622 165 HOH HOH A . 
D 3 HOH 223 623 247 HOH HOH A . 
D 3 HOH 224 624 228 HOH HOH A . 
D 3 HOH 225 625 199 HOH HOH A . 
D 3 HOH 226 626 230 HOH HOH A . 
D 3 HOH 227 627 203 HOH HOH A . 
D 3 HOH 228 628 288 HOH HOH A . 
D 3 HOH 229 629 182 HOH HOH A . 
D 3 HOH 230 630 152 HOH HOH A . 
D 3 HOH 231 631 264 HOH HOH A . 
D 3 HOH 232 632 236 HOH HOH A . 
D 3 HOH 233 633 261 HOH HOH A . 
D 3 HOH 234 634 170 HOH HOH A . 
D 3 HOH 235 635 196 HOH HOH A . 
D 3 HOH 236 636 222 HOH HOH A . 
D 3 HOH 237 637 294 HOH HOH A . 
D 3 HOH 238 638 279 HOH HOH A . 
D 3 HOH 239 639 212 HOH HOH A . 
D 3 HOH 240 640 269 HOH HOH A . 
D 3 HOH 241 641 91  HOH HOH A . 
D 3 HOH 242 642 192 HOH HOH A . 
D 3 HOH 243 643 287 HOH HOH A . 
D 3 HOH 244 644 151 HOH HOH A . 
D 3 HOH 245 645 246 HOH HOH A . 
D 3 HOH 246 646 297 HOH HOH A . 
D 3 HOH 247 647 240 HOH HOH A . 
D 3 HOH 248 648 71  HOH HOH A . 
D 3 HOH 249 649 216 HOH HOH A . 
D 3 HOH 250 650 232 HOH HOH A . 
D 3 HOH 251 651 139 HOH HOH A . 
D 3 HOH 252 652 258 HOH HOH A . 
D 3 HOH 253 653 154 HOH HOH A . 
D 3 HOH 254 654 131 HOH HOH A . 
D 3 HOH 255 655 181 HOH HOH A . 
D 3 HOH 256 656 304 HOH HOH A . 
D 3 HOH 257 657 59  HOH HOH A . 
D 3 HOH 258 658 301 HOH HOH A . 
D 3 HOH 259 659 262 HOH HOH A . 
D 3 HOH 260 660 248 HOH HOH A . 
D 3 HOH 261 661 220 HOH HOH A . 
D 3 HOH 262 662 273 HOH HOH A . 
D 3 HOH 263 663 174 HOH HOH A . 
D 3 HOH 264 664 173 HOH HOH A . 
D 3 HOH 265 665 221 HOH HOH A . 
D 3 HOH 266 666 185 HOH HOH A . 
D 3 HOH 267 667 303 HOH HOH A . 
D 3 HOH 268 668 245 HOH HOH A . 
D 3 HOH 269 669 275 HOH HOH A . 
D 3 HOH 270 670 210 HOH HOH A . 
D 3 HOH 271 671 84  HOH HOH A . 
D 3 HOH 272 672 226 HOH HOH A . 
D 3 HOH 273 673 211 HOH HOH A . 
D 3 HOH 274 674 280 HOH HOH A . 
D 3 HOH 275 675 187 HOH HOH A . 
D 3 HOH 276 676 37  HOH HOH A . 
D 3 HOH 277 677 215 HOH HOH A . 
D 3 HOH 278 678 142 HOH HOH A . 
D 3 HOH 279 679 237 HOH HOH A . 
D 3 HOH 280 680 171 HOH HOH A . 
D 3 HOH 281 681 175 HOH HOH A . 
D 3 HOH 282 682 194 HOH HOH A . 
D 3 HOH 283 683 249 HOH HOH A . 
D 3 HOH 284 684 28  HOH HOH A . 
D 3 HOH 285 685 191 HOH HOH A . 
D 3 HOH 286 686 296 HOH HOH A . 
D 3 HOH 287 687 128 HOH HOH A . 
D 3 HOH 288 688 129 HOH HOH A . 
D 3 HOH 289 689 260 HOH HOH A . 
D 3 HOH 290 690 31  HOH HOH A . 
D 3 HOH 291 691 153 HOH HOH A . 
D 3 HOH 292 692 229 HOH HOH A . 
D 3 HOH 293 693 164 HOH HOH A . 
D 3 HOH 294 694 263 HOH HOH A . 
D 3 HOH 295 695 286 HOH HOH A . 
D 3 HOH 296 696 87  HOH HOH A . 
D 3 HOH 297 697 243 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A LYS 15 ? CG ? B LYS 17 CG 
2 1 Y 1 A LYS 15 ? CD ? B LYS 17 CD 
3 1 Y 1 A LYS 15 ? CE ? B LYS 17 CE 
4 1 Y 1 A LYS 15 ? NZ ? B LYS 17 NZ 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21rc1_4958 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .            2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .            3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .            4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YPE 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     82.254 
_cell.length_a_esd                 ? 
_cell.length_b                     82.254 
_cell.length_b_esd                 ? 
_cell.length_c                     123.149 
_cell.length_c_esd                 ? 
_cell.volume                       721565.166 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YPE 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YPE 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.64 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          53.37 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '20% PEG 3350, 0.2M sodium citrate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-04-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.975 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL17U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.975 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL17U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          18.66 
_reflns.entry_id                                       8YPE 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.95 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     35556 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          48.75 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.00 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.05 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.95 
_reflns_shell.d_res_low                                     2.02 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3480 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               9.3 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.65 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.59 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.96 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YPE 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.95 
_refine.ls_d_res_low                             35.57 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     33796 
_refine.ls_number_reflns_R_free                  1690 
_refine.ls_number_reflns_R_work                  32106 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.07 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1983 
_refine.ls_R_factor_R_free                       0.2248 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1969 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.0641 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1954 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.95 
_refine_hist.d_res_low                        35.57 
_refine_hist.number_atoms_solvent             304 
_refine_hist.number_atoms_total               3130 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2826 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0072  ? 2891 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9044  ? 3921 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0546  ? 440  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0079  ? 501  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.1285 ? 1071 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.95 2.01  . . 43  1394 49.47  . . . . 0.2759 . . . . . . . . . . . 0.2803 
'X-RAY DIFFRACTION' 2.01 2.08  . . 133 2531 91.64  . . . . 0.2433 . . . . . . . . . . . 0.3146 
'X-RAY DIFFRACTION' 2.08 2.15  . . 148 2763 99.86  . . . . 0.2398 . . . . . . . . . . . 0.2478 
'X-RAY DIFFRACTION' 2.15 2.24  . . 152 2796 100.00 . . . . 0.2140 . . . . . . . . . . . 0.2488 
'X-RAY DIFFRACTION' 2.24 2.34  . . 123 2794 99.97  . . . . 0.2259 . . . . . . . . . . . 0.2812 
'X-RAY DIFFRACTION' 2.34 2.46  . . 156 2774 100.00 . . . . 0.2166 . . . . . . . . . . . 0.2634 
'X-RAY DIFFRACTION' 2.46 2.62  . . 146 2790 99.90  . . . . 0.2213 . . . . . . . . . . . 0.2486 
'X-RAY DIFFRACTION' 2.62 2.82  . . 169 2794 99.97  . . . . 0.2052 . . . . . . . . . . . 0.2499 
'X-RAY DIFFRACTION' 2.82 3.10  . . 132 2834 100.00 . . . . 0.2101 . . . . . . . . . . . 0.2234 
'X-RAY DIFFRACTION' 3.10 3.55  . . 134 2851 100.00 . . . . 0.1857 . . . . . . . . . . . 0.2365 
'X-RAY DIFFRACTION' 3.55 4.47  . . 149 2863 100.00 . . . . 0.1573 . . . . . . . . . . . 0.1718 
'X-RAY DIFFRACTION' 4.47 35.57 . . 205 2922 99.21  . . . . 0.1677 . . . . . . . . . . . 0.1857 
# 
_struct.entry_id                     8YPE 
_struct.title                        'The crystal structure of inactive p38 complexed with a ATF2 from 46 to 80' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YPE 
_struct_keywords.text            'MAP KINASE P38 ALPHA, docking interactions, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ATF2_HUMAN P15336 ? 1 KHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCE 46 
2 UNP MK14_MOUSE P47811 ? 2 
;MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH
ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA
DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YPE B 1 ? 35  ? P15336 46 ? 80  ? 46 80  
2 2 8YPE A 3 ? 362 ? P47811 1  ? 360 ? 1  360 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8YPE VAL A 1 ? UNP P47811 ? ? 'expression tag' -1 1 
2 8YPE HIS A 2 ? UNP P47811 ? ? 'expression tag' 0  2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 950   ? 
1 MORE         -7    ? 
1 'SSA (A^2)'  17660 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER B 63  ? MET B 80  ? SER A 61  MET A 78  1 ? 18 
HELX_P HELX_P2  AA2 LEU B 115 ? LYS B 120 ? LEU A 113 LYS A 118 1 ? 6  
HELX_P HELX_P3  AA3 THR B 125 ? ALA B 146 ? THR A 123 ALA A 144 1 ? 22 
HELX_P HELX_P4  AA4 LYS B 154 ? SER B 156 ? LYS A 152 SER A 154 5 ? 3  
HELX_P HELX_P5  AA5 ALA B 192 ? LEU B 197 ? ALA A 190 LEU A 195 1 ? 6  
HELX_P HELX_P6  AA6 GLN B 204 ? GLY B 221 ? GLN A 202 GLY A 219 1 ? 18 
HELX_P HELX_P7  AA7 ASP B 229 ? GLY B 242 ? ASP A 227 GLY A 240 1 ? 14 
HELX_P HELX_P8  AA8 GLY B 245 ? ILE B 252 ? GLY A 243 ILE A 250 1 ? 8  
HELX_P HELX_P9  AA9 SER B 254 ? SER B 263 ? SER A 252 SER A 261 1 ? 10 
HELX_P HELX_P10 AB1 ASN B 271 ? PHE B 276 ? ASN A 269 PHE A 274 1 ? 6  
HELX_P HELX_P11 AB2 ASN B 280 ? LEU B 291 ? ASN A 278 LEU A 289 1 ? 12 
HELX_P HELX_P12 AB3 ASP B 294 ? ARG B 298 ? ASP A 292 ARG A 296 5 ? 5  
HELX_P HELX_P13 AB4 THR B 300 ? ALA B 306 ? THR A 298 ALA A 304 1 ? 7  
HELX_P HELX_P14 AB5 HIS B 307 ? ALA B 311 ? HIS A 305 ALA A 309 5 ? 5  
HELX_P HELX_P15 AB6 ASP B 315 ? GLU B 319 ? ASP A 313 GLU A 317 5 ? 5  
HELX_P HELX_P16 AB7 GLN B 327 ? ARG B 332 ? GLN A 325 ARG A 330 5 ? 6  
HELX_P HELX_P17 AB8 LEU B 335 ? SER B 349 ? LEU A 333 SER A 347 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE B 10  ? GLU B 14  ? PHE A 8   GLU A 12  
AA1 2 ILE B 19  ? PRO B 23  ? ILE A 17  PRO A 21  
AA2 1 TYR B 26  ? SER B 34  ? TYR A 24  SER A 32  
AA2 2 GLY B 38  ? ASP B 45  ? GLY A 36  ASP A 43  
AA2 3 HIS B 50  ? LEU B 57  ? HIS A 48  LEU A 55  
AA2 4 TYR B 105 ? HIS B 109 ? TYR A 103 HIS A 107 
AA2 5 ASP B 90  ? PHE B 92  ? ASP A 88  PHE A 90  
AA3 1 ALA B 113 ? ASP B 114 ? ALA A 111 ASP A 112 
AA3 2 LEU B 158 ? VAL B 160 ? LEU A 156 VAL A 158 
AA3 3 LEU B 166 ? ILE B 168 ? LEU A 164 ILE A 166 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN B 13  ? N GLN A 11  O TRP B 20  ? O TRP A 18  
AA2 1 2 N GLN B 27  ? N GLN A 25  O PHE B 44  ? O PHE A 42  
AA2 2 3 N ASP B 45  ? N ASP A 43  O HIS B 50  ? O HIS A 48  
AA2 3 4 N LYS B 55  ? N LYS A 53  O LEU B 106 ? O LEU A 104 
AA2 4 5 O VAL B 107 ? O VAL A 105 N ASP B 90  ? N ASP A 88  
AA3 1 2 N ALA B 113 ? N ALA A 111 O VAL B 160 ? O VAL A 158 
AA3 2 3 N ALA B 159 ? N ALA A 157 O LYS B 167 ? O LYS A 165 
# 
_pdbx_entry_details.entry_id                   8YPE 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 57  ? ? 38.99  67.07  
2 1 ARG A 149 ? ? 76.43  -18.63 
3 1 LEU A 289 ? ? -96.35 49.93  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 696 ? 5.91 . 
2 1 O ? A HOH 697 ? 5.95 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B LYS 46  ? A LYS 1   
2  1 Y 1 B HIS 47  ? A HIS 2   
3  1 Y 1 B LYS 48  ? A LYS 3   
4  1 Y 1 B HIS 49  ? A HIS 4   
5  1 Y 1 B PRO 57  ? A PRO 12  
6  1 Y 1 B ALA 58  ? A ALA 13  
7  1 Y 1 B ARG 59  ? A ARG 14  
8  1 Y 1 B ASN 60  ? A ASN 15  
9  1 Y 1 B ASP 61  ? A ASP 16  
10 1 Y 1 B SER 62  ? A SER 17  
11 1 Y 1 B VAL 63  ? A VAL 18  
12 1 Y 1 B ILE 64  ? A ILE 19  
13 1 Y 1 B VAL 65  ? A VAL 20  
14 1 Y 1 B ALA 66  ? A ALA 21  
15 1 Y 1 B ASP 67  ? A ASP 22  
16 1 Y 1 B GLN 68  ? A GLN 23  
17 1 Y 1 B THR 69  ? A THR 24  
18 1 Y 1 B PRO 70  ? A PRO 25  
19 1 Y 1 B THR 71  ? A THR 26  
20 1 Y 1 B PRO 72  ? A PRO 27  
21 1 Y 1 B THR 73  ? A THR 28  
22 1 Y 1 B ARG 74  ? A ARG 29  
23 1 Y 1 B PHE 75  ? A PHE 30  
24 1 Y 1 B LEU 76  ? A LEU 31  
25 1 Y 1 B LYS 77  ? A LYS 32  
26 1 Y 1 B ASN 78  ? A ASN 33  
27 1 Y 1 B CYS 79  ? A CYS 34  
28 1 Y 1 B GLU 80  ? A GLU 35  
29 1 Y 1 A ARG 173 ? B ARG 175 
30 1 Y 1 A HIS 174 ? B HIS 176 
31 1 Y 1 A THR 175 ? B THR 177 
32 1 Y 1 A ASP 176 ? B ASP 178 
33 1 Y 1 A ASP 177 ? B ASP 179 
34 1 Y 1 A GLU 178 ? B GLU 180 
35 1 Y 1 A MET 179 ? B MET 181 
36 1 Y 1 A THR 180 ? B THR 182 
37 1 Y 1 A GLY 181 ? B GLY 183 
38 1 Y 1 A TYR 182 ? B TYR 184 
39 1 Y 1 A VAL 183 ? B VAL 185 
40 1 Y 1 A ASP 354 ? B ASP 356 
41 1 Y 1 A GLN 355 ? B GLN 357 
42 1 Y 1 A GLU 356 ? B GLU 358 
43 1 Y 1 A GLU 357 ? B GLU 359 
44 1 Y 1 A MET 358 ? B MET 360 
45 1 Y 1 A GLU 359 ? B GLU 361 
46 1 Y 1 A SER 360 ? B SER 362 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministry of Science and Technology (MoST, China)' China 2019YFA0802500 1 
'Ministry of Science and Technology (MoST, China)' China 2022YFA0806504 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1P38 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YPE 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012157 
_atom_sites.fract_transf_matrix[1][2]   0.007019 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014038 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008120 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 5   ? 23.06172 -5.49099  23.13185  1.000 53.67478  ? 50  GLU B N   1 
ATOM   2    C CA  . GLU A 1 5   ? 23.76938 -4.81316  22.04695  1.000 51.57478  ? 50  GLU B CA  1 
ATOM   3    C C   . GLU A 1 5   ? 24.07938 -3.34879  22.38835  1.000 50.40478  ? 50  GLU B C   1 
ATOM   4    O O   . GLU A 1 5   ? 24.97238 -2.73628  21.78634  1.000 52.70478  ? 50  GLU B O   1 
ATOM   5    C CB  . GLU A 1 5   ? 22.94770 -4.88044  20.75646  1.000 45.52478  ? 50  GLU B CB  1 
ATOM   6    C CG  . GLU A 1 5   ? 23.69932 -4.41519  19.52330  1.000 41.93478  ? 50  GLU B CG  1 
ATOM   7    C CD  . GLU A 1 5   ? 22.81063 -4.19972  18.34602  1.000 39.88478  ? 50  GLU B CD  1 
ATOM   8    O OE1 . GLU A 1 5   ? 21.58809 -4.42261  18.49996  1.000 41.76478  ? 50  GLU B OE1 1 
ATOM   9    O OE2 . GLU A 1 5   ? 23.33320 -3.80067  17.27386  1.000 46.49478  ? 50  GLU B OE2 1 
ATOM   10   N N   . MET A 1 6   ? 23.35643 -2.82153  23.38274  1.000 57.42323  ? 51  MET B N   1 
ATOM   11   C CA  . MET A 1 6   ? 23.30354 -1.38059  23.62687  1.000 53.81323  ? 51  MET B CA  1 
ATOM   12   C C   . MET A 1 6   ? 24.68777 -0.79115  23.90133  1.000 47.99323  ? 51  MET B C   1 
ATOM   13   O O   . MET A 1 6   ? 25.21974 -0.02989  23.08444  1.000 58.99323  ? 51  MET B O   1 
ATOM   14   C CB  . MET A 1 6   ? 22.34473 -1.10204  24.78503  1.000 56.98323  ? 51  MET B CB  1 
ATOM   15   C CG  . MET A 1 6   ? 22.24754 -2.26605  25.75771  1.000 60.01323  ? 51  MET B CG  1 
ATOM   16   S SD  . MET A 1 6   ? 22.10798 -1.75864  27.47910  1.000 68.61323  ? 51  MET B SD  1 
ATOM   17   C CE  . MET A 1 6   ? 23.00350 -0.19914  27.46395  1.000 56.20323  ? 51  MET B CE  1 
ATOM   18   N N   . THR A 1 7   ? 25.30441 -1.16518  25.02238  1.000 53.03674  ? 52  THR B N   1 
ATOM   19   C CA  . THR A 1 7   ? 26.53694 -0.53068  25.47721  1.000 41.63674  ? 52  THR B CA  1 
ATOM   20   C C   . THR A 1 7   ? 27.19116 -1.43985  26.51451  1.000 35.37674  ? 52  THR B C   1 
ATOM   21   O O   . THR A 1 7   ? 26.49994 -2.18662  27.21924  1.000 37.38674  ? 52  THR B O   1 
ATOM   22   C CB  . THR A 1 7   ? 26.23754 0.88628   26.02920  1.000 46.63674  ? 52  THR B CB  1 
ATOM   23   O OG1 . THR A 1 7   ? 26.62638 1.87284   25.06352  1.000 53.61674  ? 52  THR B OG1 1 
ATOM   24   C CG2 . THR A 1 7   ? 26.89569 1.19215   27.38292  1.000 49.56674  ? 52  THR B CG2 1 
ATOM   25   N N   . LEU A 1 8   ? 28.52869 -1.41521  26.55588  1.000 28.31740  ? 53  LEU B N   1 
ATOM   26   C CA  . LEU A 1 8   ? 29.31156 -2.17739  27.51813  1.000 27.58740  ? 53  LEU B CA  1 
ATOM   27   C C   . LEU A 1 8   ? 30.27478 -1.25446  28.24882  1.000 28.28740  ? 53  LEU B C   1 
ATOM   28   O O   . LEU A 1 8   ? 30.73332 -0.25846  27.69185  1.000 28.24740  ? 53  LEU B O   1 
ATOM   29   C CB  . LEU A 1 8   ? 30.11528 -3.29351  26.83566  1.000 24.61740  ? 53  LEU B CB  1 
ATOM   30   C CG  . LEU A 1 8   ? 29.36879 -4.45918  26.18629  1.000 24.67740  ? 53  LEU B CG  1 
ATOM   31   C CD1 . LEU A 1 8   ? 30.33787 -5.31797  25.39214  1.000 20.37740  ? 53  LEU B CD1 1 
ATOM   32   C CD2 . LEU A 1 8   ? 28.66853 -5.29494  27.25348  1.000 25.08740  ? 53  LEU B CD2 1 
ATOM   33   N N   . LYS A 1 9   ? 30.59048 -1.60222  29.49761  1.000 23.20312  ? 54  LYS B N   1 
ATOM   34   C CA  . LYS A 1 9   ? 31.59804 -0.89256  30.27615  1.000 25.51312  ? 54  LYS B CA  1 
ATOM   35   C C   . LYS A 1 9   ? 32.97069 -1.44879  29.94696  1.000 31.96312  ? 54  LYS B C   1 
ATOM   36   O O   . LYS A 1 9   ? 33.12096 -2.64331  29.68401  1.000 30.98312  ? 54  LYS B O   1 
ATOM   37   C CB  . LYS A 1 9   ? 31.37128 -1.04446  31.78458  1.000 26.44312  ? 54  LYS B CB  1 
ATOM   38   C CG  . LYS A 1 9   ? 30.00828 -0.66450  32.31004  1.000 32.53312  ? 54  LYS B CG  1 
ATOM   39   C CD  . LYS A 1 9   ? 29.95627 -0.86734  33.82472  1.000 35.13312  ? 54  LYS B CD  1 
ATOM   40   C CE  . LYS A 1 9   ? 28.55529 -0.61995  34.36038  1.000 39.49312  ? 54  LYS B CE  1 
ATOM   41   N NZ  . LYS A 1 9   ? 28.49785 -0.63996  35.85097  1.000 39.46312  ? 54  LYS B NZ  1 
ATOM   42   N N   . PHE A 1 10  ? 33.98293 -0.58673  29.98879  1.000 33.64556  ? 55  PHE B N   1 
ATOM   43   C CA  . PHE A 1 10  ? 35.35529 -1.05843  29.86870  1.000 46.97556  ? 55  PHE B CA  1 
ATOM   44   C C   . PHE A 1 10  ? 35.92128 -1.33806  31.25465  1.000 40.14556  ? 55  PHE B C   1 
ATOM   45   O O   . PHE A 1 10  ? 35.79887 -0.50780  32.15974  1.000 48.62556  ? 55  PHE B O   1 
ATOM   46   C CB  . PHE A 1 10  ? 36.24760 -0.05089  29.14003  1.000 62.21556  ? 55  PHE B CB  1 
ATOM   47   C CG  . PHE A 1 10  ? 37.71457 -0.39595  29.21505  1.000 80.73556  ? 55  PHE B CG  1 
ATOM   48   C CD1 . PHE A 1 10  ? 38.22147 -1.46866  28.49188  1.000 88.28556  ? 55  PHE B CD1 1 
ATOM   49   C CD2 . PHE A 1 10  ? 38.57962 0.32989   30.02802  1.000 91.20556  ? 55  PHE B CD2 1 
ATOM   50   C CE1 . PHE A 1 10  ? 39.56212 -1.80482  28.56519  1.000 95.03556  ? 55  PHE B CE1 1 
ATOM   51   C CE2 . PHE A 1 10  ? 39.92291 -0.00161  30.10798  1.000 99.02556  ? 55  PHE B CE2 1 
ATOM   52   C CZ  . PHE A 1 10  ? 40.41440 -1.06989  29.37405  1.000 104.67556 ? 55  PHE B CZ  1 
ATOM   53   N N   . GLY A 1 11  ? 36.56118 -2.49296  31.40846  1.000 55.47251  ? 56  GLY B N   1 
ATOM   54   C CA  . GLY A 1 11  ? 37.19367 -2.85350  32.66596  1.000 61.64251  ? 56  GLY B CA  1 
ATOM   55   C C   . GLY A 1 11  ? 38.47562 -2.09336  32.94133  1.000 59.00251  ? 56  GLY B C   1 
ATOM   56   O O   . GLY A 1 11  ? 39.56797 -2.65648  32.87880  1.000 69.96251  ? 56  GLY B O   1 
ATOM   57   N N   . VAL B 2 1   ? 60.01667 1.80833   -7.91244  1.000 37.77069  ? -1  VAL A N   1 
ATOM   58   C CA  . VAL B 2 1   ? 58.90537 0.92297   -8.26926  1.000 38.20069  ? -1  VAL A CA  1 
ATOM   59   C C   . VAL B 2 1   ? 57.75752 1.70799   -8.91603  1.000 31.63069  ? -1  VAL A C   1 
ATOM   60   O O   . VAL B 2 1   ? 57.18583 2.63076   -8.31245  1.000 25.39069  ? -1  VAL A O   1 
ATOM   61   C CB  . VAL B 2 1   ? 58.39576 0.12790   -7.04166  1.000 40.84069  ? -1  VAL A CB  1 
ATOM   62   C CG1 . VAL B 2 1   ? 57.22363 -0.77188  -7.43168  1.000 35.86069  ? -1  VAL A CG1 1 
ATOM   63   C CG2 . VAL B 2 1   ? 59.51829 -0.70344  -6.44484  1.000 40.70069  ? -1  VAL A CG2 1 
ATOM   64   N N   . HIS B 2 2   ? 57.44216 1.30594   -10.14881 1.000 30.16417  ? 0   HIS A N   1 
ATOM   65   C CA  . HIS B 2 2   ? 56.42300 1.93088   -10.98808 1.000 25.59417  ? 0   HIS A CA  1 
ATOM   66   C C   . HIS B 2 2   ? 55.09805 2.09593   -10.24230 1.000 27.83417  ? 0   HIS A C   1 
ATOM   67   O O   . HIS B 2 2   ? 54.49685 1.11008   -9.80162  1.000 26.09417  ? 0   HIS A O   1 
ATOM   68   C CB  . HIS B 2 2   ? 56.24485 1.06467   -12.24813 1.000 22.68417  ? 0   HIS A CB  1 
ATOM   69   C CG  . HIS B 2 2   ? 55.03885 1.40821   -13.06036 1.000 22.74417  ? 0   HIS A CG  1 
ATOM   70   N ND1 . HIS B 2 2   ? 54.98621 2.51264   -13.88229 1.000 19.35417  ? 0   HIS A ND1 1 
ATOM   71   C CD2 . HIS B 2 2   ? 53.84322 0.78532   -13.19204 1.000 25.90417  ? 0   HIS A CD2 1 
ATOM   72   C CE1 . HIS B 2 2   ? 53.80638 2.56725   -14.47406 1.000 20.86417  ? 0   HIS A CE1 1 
ATOM   73   N NE2 . HIS B 2 2   ? 53.09445 1.52671   -14.07754 1.000 23.74417  ? 0   HIS A NE2 1 
ATOM   74   N N   . MET B 2 3   ? 54.70195 3.36139   -10.04349 1.000 20.04502  ? 1   MET A N   1 
ATOM   75   C CA  . MET B 2 3   ? 53.39769 3.76365   -9.49639  1.000 30.97502  ? 1   MET A CA  1 
ATOM   76   C C   . MET B 2 3   ? 53.17496 3.25398   -8.07073  1.000 35.11502  ? 1   MET A C   1 
ATOM   77   O O   . MET B 2 3   ? 52.04591 2.95228   -7.66907  1.000 46.39502  ? 1   MET A O   1 
ATOM   78   C CB  . MET B 2 3   ? 52.24418 3.34604   -10.41723 1.000 35.30502  ? 1   MET A CB  1 
ATOM   79   C CG  . MET B 2 3   ? 51.86123 4.43845   -11.44879 1.000 30.54502  ? 1   MET A CG  1 
ATOM   80   S SD  . MET B 2 3   ? 50.52072 3.96551   -12.58105 1.000 42.71502  ? 1   MET A SD  1 
ATOM   81   C CE  . MET B 2 3   ? 49.05447 4.04750   -11.53556 1.000 44.67502  ? 1   MET A CE  1 
ATOM   82   N N   . SER B 2 4   ? 54.24347 3.18594   -7.29138  1.000 32.06871  ? 2   SER A N   1 
ATOM   83   C CA  . SER B 2 4   ? 54.16502 2.80695   -5.89362  1.000 40.50871  ? 2   SER A CA  1 
ATOM   84   C C   . SER B 2 4   ? 53.84609 4.02842   -5.03064  1.000 52.94871  ? 2   SER A C   1 
ATOM   85   O O   . SER B 2 4   ? 53.94483 5.17839   -5.47145  1.000 53.79871  ? 2   SER A O   1 
ATOM   86   C CB  . SER B 2 4   ? 55.48349 2.17759   -5.45557  1.000 38.30871  ? 2   SER A CB  1 
ATOM   87   O OG  . SER B 2 4   ? 56.54075 3.11220   -5.61423  1.000 31.24871  ? 2   SER A OG  1 
ATOM   88   N N   . GLN B 2 5   ? 53.46540 3.76312   -3.77931  1.000 56.58916  ? 3   GLN A N   1 
ATOM   89   C CA  . GLN B 2 5   ? 53.21902 4.83658   -2.82493  1.000 52.92916  ? 3   GLN A CA  1 
ATOM   90   C C   . GLN B 2 5   ? 54.50605 5.60724   -2.53986  1.000 42.65916  ? 3   GLN A C   1 
ATOM   91   O O   . GLN B 2 5   ? 55.61582 5.07416   -2.64810  1.000 32.55916  ? 3   GLN A O   1 
ATOM   92   C CB  . GLN B 2 5   ? 52.65058 4.26978   -1.51987  1.000 60.76916  ? 3   GLN A CB  1 
ATOM   93   C CG  . GLN B 2 5   ? 51.31748 3.53980   -1.66333  1.000 62.69916  ? 3   GLN A CG  1 
ATOM   94   C CD  . GLN B 2 5   ? 50.11213 4.44976   -1.45786  1.000 64.20916  ? 3   GLN A CD  1 
ATOM   95   O OE1 . GLN B 2 5   ? 50.04619 5.55740   -2.00431  1.000 57.87916  ? 3   GLN A OE1 1 
ATOM   96   N NE2 . GLN B 2 5   ? 49.15129 3.98351   -0.65958  1.000 59.14916  ? 3   GLN A NE2 1 
ATOM   97   N N   . GLU B 2 6   ? 54.34896 6.88559   -2.20258  1.000 44.26352  ? 4   GLU A N   1 
ATOM   98   C CA  . GLU B 2 6   ? 55.48063 7.67845   -1.74520  1.000 40.45352  ? 4   GLU A CA  1 
ATOM   99   C C   . GLU B 2 6   ? 55.98381 7.12569   -0.41996  1.000 28.80352  ? 4   GLU A C   1 
ATOM   100  O O   . GLU B 2 6   ? 55.19795 6.65342   0.40700   1.000 26.96352  ? 4   GLU A O   1 
ATOM   101  C CB  . GLU B 2 6   ? 55.07911 9.14580   -1.58211  1.000 50.96352  ? 4   GLU A CB  1 
ATOM   102  C CG  . GLU B 2 6   ? 54.58190 9.79978   -2.86302  1.000 57.88352  ? 4   GLU A CG  1 
ATOM   103  C CD  . GLU B 2 6   ? 54.12665 11.23832  -2.66268  1.000 60.17352  ? 4   GLU A CD  1 
ATOM   104  O OE1 . GLU B 2 6   ? 54.69989 11.94176  -1.79204  1.000 56.81352  ? 4   GLU A OE1 1 
ATOM   105  O OE2 . GLU B 2 6   ? 53.18685 11.65668  -3.37915  1.000 44.24352  ? 4   GLU A OE2 1 
ATOM   106  N N   . ARG B 2 7   ? 57.29774 7.14678   -0.23127  1.000 27.09236  ? 5   ARG A N   1 
ATOM   107  C CA  . ARG B 2 7   ? 57.85490 6.66192   1.01719   1.000 25.98236  ? 5   ARG A CA  1 
ATOM   108  C C   . ARG B 2 7   ? 57.63872 7.71217   2.09567   1.000 31.39236  ? 5   ARG A C   1 
ATOM   109  O O   . ARG B 2 7   ? 58.03798 8.86623   1.91024   1.000 35.03236  ? 5   ARG A O   1 
ATOM   110  C CB  . ARG B 2 7   ? 59.34059 6.35013   0.88299   1.000 24.60236  ? 5   ARG A CB  1 
ATOM   111  C CG  . ARG B 2 7   ? 59.90135 5.61595   2.07482   1.000 24.31236  ? 5   ARG A CG  1 
ATOM   112  C CD  . ARG B 2 7   ? 61.36968 5.27748   1.90661   1.000 26.21236  ? 5   ARG A CD  1 
ATOM   113  N NE  . ARG B 2 7   ? 61.91914 4.58270   3.06848   1.000 24.73236  ? 5   ARG A NE  1 
ATOM   114  C CZ  . ARG B 2 7   ? 62.48339 5.18316   4.10674   1.000 26.10236  ? 5   ARG A CZ  1 
ATOM   115  N NH1 . ARG B 2 7   ? 62.52503 6.50262   4.20325   1.000 28.26236  ? 5   ARG A NH1 1 
ATOM   116  N NH2 . ARG B 2 7   ? 63.02408 4.44220   5.07140   1.000 24.35236  ? 5   ARG A NH2 1 
ATOM   117  N N   . PRO B 2 8   ? 57.00579 7.37238   3.20948   1.000 29.41942  ? 6   PRO A N   1 
ATOM   118  C CA  . PRO B 2 8   ? 56.89148 8.32757   4.31361   1.000 25.50942  ? 6   PRO A CA  1 
ATOM   119  C C   . PRO B 2 8   ? 58.23602 8.53954   4.99065   1.000 23.60942  ? 6   PRO A C   1 
ATOM   120  O O   . PRO B 2 8   ? 59.19743 7.80194   4.77058   1.000 22.30942  ? 6   PRO A O   1 
ATOM   121  C CB  . PRO B 2 8   ? 55.88707 7.65451   5.25727   1.000 27.79942  ? 6   PRO A CB  1 
ATOM   122  C CG  . PRO B 2 8   ? 55.98520 6.20830   4.94614   1.000 28.85942  ? 6   PRO A CG  1 
ATOM   123  C CD  . PRO B 2 8   ? 56.28245 6.11658   3.47586   1.000 28.40942  ? 6   PRO A CD  1 
ATOM   124  N N   . THR B 2 9   ? 58.29685 9.58424   5.81836   1.000 21.25326  ? 7   THR A N   1 
ATOM   125  C CA  . THR B 2 9   ? 59.44153 9.79877   6.69516   1.000 22.94326  ? 7   THR A CA  1 
ATOM   126  C C   . THR B 2 9   ? 59.36096 8.85715   7.88884   1.000 22.09326  ? 7   THR A C   1 
ATOM   127  O O   . THR B 2 9   ? 58.32566 8.77109   8.55931   1.000 20.87326  ? 7   THR A O   1 
ATOM   128  C CB  . THR B 2 9   ? 59.49644 11.25649  7.17058   1.000 25.98326  ? 7   THR A CB  1 
ATOM   129  O OG1 . THR B 2 9   ? 59.70354 12.11379  6.04295   1.000 28.20326  ? 7   THR A OG1 1 
ATOM   130  C CG2 . THR B 2 9   ? 60.62376 11.47349  8.17857   1.000 26.10326  ? 7   THR A CG2 1 
ATOM   131  N N   . PHE B 2 10  ? 60.45342 8.14676   8.15024   1.000 21.75796  ? 8   PHE A N   1 
ATOM   132  C CA  . PHE B 2 10  ? 60.56221 7.23184   9.27373   1.000 21.35796  ? 8   PHE A CA  1 
ATOM   133  C C   . PHE B 2 10  ? 61.35520 7.88750   10.39720  1.000 24.01796  ? 8   PHE A C   1 
ATOM   134  O O   . PHE B 2 10  ? 62.17585 8.77446   10.16429  1.000 29.50796  ? 8   PHE A O   1 
ATOM   135  C CB  . PHE B 2 10  ? 61.25412 5.92320   8.85281   1.000 20.87796  ? 8   PHE A CB  1 
ATOM   136  C CG  . PHE B 2 10  ? 60.40168 5.00030   8.02336   1.000 19.90796  ? 8   PHE A CG  1 
ATOM   137  C CD1 . PHE B 2 10  ? 60.07417 5.31111   6.71100   1.000 19.57796  ? 8   PHE A CD1 1 
ATOM   138  C CD2 . PHE B 2 10  ? 59.96135 3.78703   8.54719   1.000 20.19796  ? 8   PHE A CD2 1 
ATOM   139  C CE1 . PHE B 2 10  ? 59.31445 4.44684   5.94424   1.000 18.79796  ? 8   PHE A CE1 1 
ATOM   140  C CE2 . PHE B 2 10  ? 59.20554 2.91443   7.77852   1.000 17.32796  ? 8   PHE A CE2 1 
ATOM   141  C CZ  . PHE B 2 10  ? 58.87379 3.24787   6.48164   1.000 16.85796  ? 8   PHE A CZ  1 
ATOM   142  N N   . TYR B 2 11  ? 61.10607 7.43784   11.62401  1.000 22.55026  ? 9   TYR A N   1 
ATOM   143  C CA  . TYR B 2 11  ? 61.91755 7.84443   12.75909  1.000 23.68026  ? 9   TYR A CA  1 
ATOM   144  C C   . TYR B 2 11  ? 62.22634 6.61690   13.60312  1.000 25.77026  ? 9   TYR A C   1 
ATOM   145  O O   . TYR B 2 11  ? 61.45529 5.65361   13.62997  1.000 31.29026  ? 9   TYR A O   1 
ATOM   146  C CB  . TYR B 2 11  ? 61.24394 8.96030   13.59858  1.000 24.26026  ? 9   TYR A CB  1 
ATOM   147  C CG  . TYR B 2 11  ? 60.02292 8.56053   14.41532  1.000 20.34026  ? 9   TYR A CG  1 
ATOM   148  C CD1 . TYR B 2 11  ? 58.78395 8.35451   13.80493  1.000 20.45026  ? 9   TYR A CD1 1 
ATOM   149  C CD2 . TYR B 2 11  ? 60.10783 8.42254   15.79760  1.000 21.13026  ? 9   TYR A CD2 1 
ATOM   150  C CE1 . TYR B 2 11  ? 57.66005 7.99883   14.55237  1.000 18.94026  ? 9   TYR A CE1 1 
ATOM   151  C CE2 . TYR B 2 11  ? 59.00229 8.07031   16.55560  1.000 19.30026  ? 9   TYR A CE2 1 
ATOM   152  C CZ  . TYR B 2 11  ? 57.78326 7.86206   15.93213  1.000 19.97026  ? 9   TYR A CZ  1 
ATOM   153  O OH  . TYR B 2 11  ? 56.68135 7.51222   16.68042  1.000 21.73026  ? 9   TYR A OH  1 
ATOM   154  N N   . ARG B 2 12  ? 63.37643 6.65586   14.27614  1.000 25.93989  ? 10  ARG A N   1 
ATOM   155  C CA  . ARG B 2 12  ? 63.92014 5.52722   15.02475  1.000 32.01989  ? 10  ARG A CA  1 
ATOM   156  C C   . ARG B 2 12  ? 63.79729 5.75970   16.52416  1.000 31.25989  ? 10  ARG A C   1 
ATOM   157  O O   . ARG B 2 12  ? 64.02632 6.87114   17.01262  1.000 34.30989  ? 10  ARG A O   1 
ATOM   158  C CB  . ARG B 2 12  ? 65.39855 5.30093   14.68374  1.000 37.33989  ? 10  ARG A CB  1 
ATOM   159  C CG  . ARG B 2 12  ? 65.67090 4.48427   13.43838  1.000 41.29989  ? 10  ARG A CG  1 
ATOM   160  C CD  . ARG B 2 12  ? 67.15149 4.55316   13.05382  1.000 48.96989  ? 10  ARG A CD  1 
ATOM   161  N NE  . ARG B 2 12  ? 68.03049 4.16195   14.15330  1.000 59.94989  ? 10  ARG A NE  1 
ATOM   162  C CZ  . ARG B 2 12  ? 68.64147 2.98752   14.25320  1.000 64.49989  ? 10  ARG A CZ  1 
ATOM   163  N NH1 . ARG B 2 12  ? 68.50990 2.05684   13.32063  1.000 64.88989  ? 10  ARG A NH1 1 
ATOM   164  N NH2 . ARG B 2 12  ? 69.40643 2.74186   15.31433  1.000 65.48989  ? 10  ARG A NH2 1 
ATOM   165  N N   . GLN B 2 13  ? 63.45265 4.70497   17.25310  1.000 30.00762  ? 11  GLN A N   1 
ATOM   166  C CA  . GLN B 2 13  ? 63.45521 4.74640   18.70603  1.000 34.11762  ? 11  GLN A CA  1 
ATOM   167  C C   . GLN B 2 13  ? 63.69553 3.34056   19.23529  1.000 38.05762  ? 11  GLN A C   1 
ATOM   168  O O   . GLN B 2 13  ? 63.37711 2.34673   18.57492  1.000 30.18762  ? 11  GLN A O   1 
ATOM   169  C CB  . GLN B 2 13  ? 62.14256 5.30318   19.25843  1.000 35.99762  ? 11  GLN A CB  1 
ATOM   170  C CG  . GLN B 2 13  ? 60.95096 4.47445   18.88374  1.000 38.45762  ? 11  GLN A CG  1 
ATOM   171  C CD  . GLN B 2 13  ? 59.64314 5.14043   19.23778  1.000 45.68762  ? 11  GLN A CD  1 
ATOM   172  O OE1 . GLN B 2 13  ? 59.41133 5.49097   20.39319  1.000 54.97762  ? 11  GLN A OE1 1 
ATOM   173  N NE2 . GLN B 2 13  ? 58.77570 5.31574   18.24415  1.000 43.75762  ? 11  GLN A NE2 1 
ATOM   174  N N   . GLU B 2 14  ? 64.27324 3.26213   20.42642  1.000 37.22065  ? 12  GLU A N   1 
ATOM   175  C CA  . GLU B 2 14  ? 64.49452 1.98674   21.09181  1.000 43.91065  ? 12  GLU A CA  1 
ATOM   176  C C   . GLU B 2 14  ? 63.43864 1.80215   22.17215  1.000 47.24065  ? 12  GLU A C   1 
ATOM   177  O O   . GLU B 2 14  ? 63.26218 2.67643   23.02559  1.000 50.68065  ? 12  GLU A O   1 
ATOM   178  C CB  . GLU B 2 14  ? 65.89832 1.90881   21.68532  1.000 51.18065  ? 12  GLU A CB  1 
ATOM   179  C CG  . GLU B 2 14  ? 66.24313 0.54530   22.25968  1.000 60.97065  ? 12  GLU A CG  1 
ATOM   180  C CD  . GLU B 2 14  ? 67.72546 0.39513   22.55709  1.000 68.71065  ? 12  GLU A CD  1 
ATOM   181  O OE1 . GLU B 2 14  ? 68.54447 0.62813   21.63956  1.000 66.47065  ? 12  GLU A OE1 1 
ATOM   182  O OE2 . GLU B 2 14  ? 68.06879 0.05085   23.71019  1.000 72.22065  ? 12  GLU A OE2 1 
ATOM   183  N N   . LEU B 2 15  ? 62.72308 0.67734   22.11095  1.000 41.22207  ? 13  LEU A N   1 
ATOM   184  C CA  . LEU B 2 15  ? 61.63835 0.36742   23.03762  1.000 50.65207  ? 13  LEU A CA  1 
ATOM   185  C C   . LEU B 2 15  ? 61.76451 -1.08724  23.46232  1.000 62.68207  ? 13  LEU A C   1 
ATOM   186  O O   . LEU B 2 15  ? 61.60243 -1.98755  22.62812  1.000 59.41207  ? 13  LEU A O   1 
ATOM   187  C CB  . LEU B 2 15  ? 60.26556 0.60652   22.39879  1.000 57.00207  ? 13  LEU A CB  1 
ATOM   188  C CG  . LEU B 2 15  ? 59.82701 2.01873   22.01541  1.000 58.08207  ? 13  LEU A CG  1 
ATOM   189  C CD1 . LEU B 2 15  ? 58.42871 1.94507   21.44323  1.000 51.66207  ? 13  LEU A CD1 1 
ATOM   190  C CD2 . LEU B 2 15  ? 59.87270 2.96456   23.20794  1.000 62.31207  ? 13  LEU A CD2 1 
ATOM   191  N N   . ASN B 2 16  ? 62.01800 -1.30271  24.76001  1.000 69.06483  ? 14  ASN A N   1 
ATOM   192  C CA  . ASN B 2 16  ? 62.28689 -2.62376  25.33986  1.000 64.46483  ? 14  ASN A CA  1 
ATOM   193  C C   . ASN B 2 16  ? 63.43372 -3.32044  24.61036  1.000 59.65483  ? 14  ASN A C   1 
ATOM   194  O O   . ASN B 2 16  ? 63.30715 -4.45924  24.14971  1.000 52.97483  ? 14  ASN A O   1 
ATOM   195  C CB  . ASN B 2 16  ? 61.02941 -3.50115  25.35203  1.000 72.40483  ? 14  ASN A CB  1 
ATOM   196  C CG  . ASN B 2 16  ? 60.12587 -3.21380  26.53404  1.000 77.66483  ? 14  ASN A CG  1 
ATOM   197  O OD1 . ASN B 2 16  ? 60.16072 -2.12424  27.10902  1.000 84.26483  ? 14  ASN A OD1 1 
ATOM   198  N ND2 . ASN B 2 16  ? 59.31204 -4.19779  26.90808  1.000 75.68483  ? 14  ASN A ND2 1 
ATOM   199  N N   . LYS B 2 17  ? 64.55646 -2.59711  24.48800  1.000 63.69092  ? 15  LYS A N   1 
ATOM   200  C CA  . LYS B 2 17  ? 65.78466 -3.07785  23.84157  1.000 61.73092  ? 15  LYS A CA  1 
ATOM   201  C C   . LYS B 2 17  ? 65.54265 -3.53727  22.40228  1.000 57.96092  ? 15  LYS A C   1 
ATOM   202  O O   . LYS B 2 17  ? 66.20929 -4.45268  21.90907  1.000 52.72092  ? 15  LYS A O   1 
ATOM   203  C CB  . LYS B 2 17  ? 66.44765 -4.19506  24.65805  1.000 58.83092  ? 15  LYS A CB  1 
ATOM   204  N N   . THR B 2 18  ? 64.58412 -2.90744  21.72503  1.000 55.20635  ? 16  THR A N   1 
ATOM   205  C CA  . THR B 2 18  ? 64.23821 -3.21505  20.34319  1.000 50.99635  ? 16  THR A CA  1 
ATOM   206  C C   . THR B 2 18  ? 64.20962 -1.90660  19.57203  1.000 38.32635  ? 16  THR A C   1 
ATOM   207  O O   . THR B 2 18  ? 63.56052 -0.95151  20.00654  1.000 38.20635  ? 16  THR A O   1 
ATOM   208  C CB  . THR B 2 18  ? 62.86411 -3.91027  20.24198  1.000 57.94635  ? 16  THR A CB  1 
ATOM   209  O OG1 . THR B 2 18  ? 62.69691 -4.84148  21.32089  1.000 65.72635  ? 16  THR A OG1 1 
ATOM   210  C CG2 . THR B 2 18  ? 62.71920 -4.64648  18.91350  1.000 50.55635  ? 16  THR A CG2 1 
ATOM   211  N N   . ILE B 2 19  ? 64.90808 -1.84958  18.44330  1.000 36.43696  ? 17  ILE A N   1 
ATOM   212  C CA  . ILE B 2 19  ? 64.84297 -0.66628  17.59028  1.000 35.41696  ? 17  ILE A CA  1 
ATOM   213  C C   . ILE B 2 19  ? 63.57205 -0.71950  16.75164  1.000 34.03696  ? 17  ILE A C   1 
ATOM   214  O O   . ILE B 2 19  ? 63.31302 -1.70336  16.04726  1.000 41.67696  ? 17  ILE A O   1 
ATOM   215  C CB  . ILE B 2 19  ? 66.08359 -0.56009  16.69699  1.000 38.43696  ? 17  ILE A CB  1 
ATOM   216  C CG1 . ILE B 2 19  ? 67.35248 -0.52006  17.54769  1.000 44.71696  ? 17  ILE A CG1 1 
ATOM   217  C CG2 . ILE B 2 19  ? 65.98560 0.68375   15.82728  1.000 39.25696  ? 17  ILE A CG2 1 
ATOM   218  C CD1 . ILE B 2 19  ? 67.52920 0.77130   18.32872  1.000 46.90696  ? 17  ILE A CD1 1 
ATOM   219  N N   . TRP B 2 20  ? 62.77534 0.33851   16.82493  1.000 28.54801  ? 18  TRP A N   1 
ATOM   220  C CA  . TRP B 2 20  ? 61.56963 0.48192   16.02275  1.000 25.55801  ? 18  TRP A CA  1 
ATOM   221  C C   . TRP B 2 20  ? 61.78410 1.64737   15.06989  1.000 24.47801  ? 18  TRP A C   1 
ATOM   222  O O   . TRP B 2 20  ? 62.10986 2.75705   15.50467  1.000 25.15801  ? 18  TRP A O   1 
ATOM   223  C CB  . TRP B 2 20  ? 60.34037 0.71319   16.90579  1.000 27.83801  ? 18  TRP A CB  1 
ATOM   224  C CG  . TRP B 2 20  ? 59.94792 -0.50530  17.69786  1.000 31.50801  ? 18  TRP A CG  1 
ATOM   225  C CD1 . TRP B 2 20  ? 60.69705 -1.14106  18.64862  1.000 38.89801  ? 18  TRP A CD1 1 
ATOM   226  C CD2 . TRP B 2 20  ? 58.71472 -1.23618  17.60750  1.000 25.33801  ? 18  TRP A CD2 1 
ATOM   227  N NE1 . TRP B 2 20  ? 60.01371 -2.22229  19.14588  1.000 37.41801  ? 18  TRP A NE1 1 
ATOM   228  C CE2 . TRP B 2 20  ? 58.79410 -2.30269  18.52625  1.000 31.57801  ? 18  TRP A CE2 1 
ATOM   229  C CE3 . TRP B 2 20  ? 57.55827 -1.09497  16.83874  1.000 21.24801  ? 18  TRP A CE3 1 
ATOM   230  C CZ2 . TRP B 2 20  ? 57.76337 -3.22189  18.69238  1.000 28.41801  ? 18  TRP A CZ2 1 
ATOM   231  C CZ3 . TRP B 2 20  ? 56.53891 -2.00205  17.01130  1.000 23.28801  ? 18  TRP A CZ3 1 
ATOM   232  C CH2 . TRP B 2 20  ? 56.64498 -3.05296  17.92956  1.000 24.18801  ? 18  TRP A CH2 1 
ATOM   233  N N   . GLU B 2 21  ? 61.62449 1.39405   13.77754  1.000 21.94504  ? 19  GLU A N   1 
ATOM   234  C CA  . GLU B 2 21  ? 61.70890 2.43313   12.76154  1.000 20.04504  ? 19  GLU A CA  1 
ATOM   235  C C   . GLU B 2 21  ? 60.37881 2.41745   12.02299  1.000 19.07504  ? 19  GLU A C   1 
ATOM   236  O O   . GLU B 2 21  ? 60.08599 1.46726   11.28720  1.000 18.37504  ? 19  GLU A O   1 
ATOM   237  C CB  . GLU B 2 21  ? 62.89865 2.20285   11.82534  1.000 23.86504  ? 19  GLU A CB  1 
ATOM   238  C CG  . GLU B 2 21  ? 63.16591 3.36079   10.86336  1.000 29.00504  ? 19  GLU A CG  1 
ATOM   239  C CD  . GLU B 2 21  ? 64.51812 3.26186   10.14750  1.000 36.08504  ? 19  GLU A CD  1 
ATOM   240  O OE1 . GLU B 2 21  ? 65.19176 2.20988   10.24669  1.000 36.17504  ? 19  GLU A OE1 1 
ATOM   241  O OE2 . GLU B 2 21  ? 64.90465 4.24436   9.47890   1.000 41.56504  ? 19  GLU A OE2 1 
ATOM   242  N N   . VAL B 2 22  ? 59.55268 3.43678   12.26172  1.000 17.81835  ? 20  VAL A N   1 
ATOM   243  C CA  . VAL B 2 22  ? 58.16984 3.46270   11.78206  1.000 17.35835  ? 20  VAL A CA  1 
ATOM   244  C C   . VAL B 2 22  ? 57.91651 4.81842   11.13733  1.000 16.13835  ? 20  VAL A C   1 
ATOM   245  O O   . VAL B 2 22  ? 58.63746 5.78796   11.41548  1.000 18.24835  ? 20  VAL A O   1 
ATOM   246  C CB  . VAL B 2 22  ? 57.15584 3.19271   12.92806  1.000 16.77835  ? 20  VAL A CB  1 
ATOM   247  C CG1 . VAL B 2 22  ? 57.51116 1.92014   13.72327  1.000 15.37835  ? 20  VAL A CG1 1 
ATOM   248  C CG2 . VAL B 2 22  ? 57.02727 4.41351   13.84902  1.000 17.13835  ? 20  VAL A CG2 1 
ATOM   249  N N   . PRO B 2 23  ? 56.90993 4.92157   10.26396  1.000 15.87887  ? 21  PRO A N   1 
ATOM   250  C CA  . PRO B 2 23  ? 56.54900 6.23877   9.71965   1.000 15.57887  ? 21  PRO A CA  1 
ATOM   251  C C   . PRO B 2 23  ? 56.08076 7.20539   10.80610  1.000 18.27887  ? 21  PRO A C   1 
ATOM   252  O O   . PRO B 2 23  ? 55.58028 6.79700   11.86374  1.000 15.48887  ? 21  PRO A O   1 
ATOM   253  C CB  . PRO B 2 23  ? 55.42202 5.92161   8.72939   1.000 15.85887  ? 21  PRO A CB  1 
ATOM   254  C CG  . PRO B 2 23  ? 55.67784 4.48328   8.32837   1.000 15.16887  ? 21  PRO A CG  1 
ATOM   255  C CD  . PRO B 2 23  ? 56.20192 3.82979   9.56609   1.000 14.86887  ? 21  PRO A CD  1 
ATOM   256  N N   . GLU B 2 24  ? 56.27090 8.50862   10.51632  1.000 17.44631  ? 22  GLU A N   1 
ATOM   257  C CA  . GLU B 2 24  ? 55.85337 9.59935   11.40614  1.000 21.14631  ? 22  GLU A CA  1 
ATOM   258  C C   . GLU B 2 24  ? 54.38440 9.51422   11.78010  1.000 17.23631  ? 22  GLU A C   1 
ATOM   259  O O   . GLU B 2 24  ? 53.98807 9.98307   12.85062  1.000 16.70631  ? 22  GLU A O   1 
ATOM   260  C CB  . GLU B 2 24  ? 56.06976 10.95507  10.72799  1.000 22.40631  ? 22  GLU A CB  1 
ATOM   261  C CG  . GLU B 2 24  ? 57.48042 11.42692  10.60616  1.000 30.81631  ? 22  GLU A CG  1 
ATOM   262  C CD  . GLU B 2 24  ? 57.52805 12.80763  9.95953   1.000 27.49631  ? 22  GLU A CD  1 
ATOM   263  O OE1 . GLU B 2 24  ? 56.92190 12.98564  8.87344   1.000 27.72631  ? 22  GLU A OE1 1 
ATOM   264  O OE2 . GLU B 2 24  ? 58.14758 13.71168  10.55031  1.000 34.96631  ? 22  GLU A OE2 1 
ATOM   265  N N   . ARG B 2 25  ? 53.57043 8.99356   10.87072  1.000 18.42737  ? 23  ARG A N   1 
ATOM   266  C CA  . ARG B 2 25  ? 52.15700 8.70349   11.04291  1.000 18.15737  ? 23  ARG A CA  1 
ATOM   267  C C   . ARG B 2 25  ? 51.83319 8.05516   12.38617  1.000 17.45737  ? 23  ARG A C   1 
ATOM   268  O O   . ARG B 2 25  ? 50.84822 8.42468   13.03351  1.000 17.21737  ? 23  ARG A O   1 
ATOM   269  C CB  . ARG B 2 25  ? 51.73060 7.80912   9.87986   1.000 22.73737  ? 23  ARG A CB  1 
ATOM   270  C CG  . ARG B 2 25  ? 50.47520 7.05561   10.08117  1.000 24.97737  ? 23  ARG A CG  1 
ATOM   271  C CD  . ARG B 2 25  ? 50.07373 6.38558   8.80387   1.000 24.10737  ? 23  ARG A CD  1 
ATOM   272  N NE  . ARG B 2 25  ? 48.81216 5.68120   8.95731   1.000 24.80737  ? 23  ARG A NE  1 
ATOM   273  C CZ  . ARG B 2 25  ? 48.31180 4.84405   8.06101   1.000 24.60737  ? 23  ARG A CZ  1 
ATOM   274  N NH1 . ARG B 2 25  ? 48.94499 4.59019   6.92470   1.000 20.24737  ? 23  ARG A NH1 1 
ATOM   275  N NH2 . ARG B 2 25  ? 47.14713 4.25076   8.31088   1.000 23.69737  ? 23  ARG A NH2 1 
ATOM   276  N N   . TYR B 2 26  ? 52.65966 7.10961   12.82742  1.000 17.79330  ? 24  TYR A N   1 
ATOM   277  C CA  . TYR B 2 26  ? 52.42045 6.39792   14.07762  1.000 19.34330  ? 24  TYR A CA  1 
ATOM   278  C C   . TYR B 2 26  ? 53.17266 7.09025   15.20278  1.000 19.01330  ? 24  TYR A C   1 
ATOM   279  O O   . TYR B 2 26  ? 54.40163 7.20278   15.15713  1.000 23.08330  ? 24  TYR A O   1 
ATOM   280  C CB  . TYR B 2 26  ? 52.82615 4.92595   13.95623  1.000 16.60330  ? 24  TYR A CB  1 
ATOM   281  C CG  . TYR B 2 26  ? 52.12069 4.28536   12.79296  1.000 16.38330  ? 24  TYR A CG  1 
ATOM   282  C CD1 . TYR B 2 26  ? 50.75808 4.06827   12.83897  1.000 14.15330  ? 24  TYR A CD1 1 
ATOM   283  C CD2 . TYR B 2 26  ? 52.80477 3.96604   11.62062  1.000 16.51330  ? 24  TYR A CD2 1 
ATOM   284  C CE1 . TYR B 2 26  ? 50.10193 3.53979   11.78529  1.000 16.04330  ? 24  TYR A CE1 1 
ATOM   285  C CE2 . TYR B 2 26  ? 52.13946 3.42958   10.54486  1.000 14.87330  ? 24  TYR A CE2 1 
ATOM   286  C CZ  . TYR B 2 26  ? 50.79223 3.20996   10.64546  1.000 15.31330  ? 24  TYR A CZ  1 
ATOM   287  O OH  . TYR B 2 26  ? 50.09532 2.67975   9.60270   1.000 14.85330  ? 24  TYR A OH  1 
ATOM   288  N N   . GLN B 2 27  ? 52.42879 7.54054   16.21534  1.000 19.80086  ? 25  GLN A N   1 
ATOM   289  C CA  . GLN B 2 27  ? 52.95786 8.33020   17.31545  1.000 20.42086  ? 25  GLN A CA  1 
ATOM   290  C C   . GLN B 2 27  ? 52.62953 7.68305   18.65463  1.000 21.18086  ? 25  GLN A C   1 
ATOM   291  O O   . GLN B 2 27  ? 51.70609 6.86978   18.76448  1.000 23.40086  ? 25  GLN A O   1 
ATOM   292  C CB  . GLN B 2 27  ? 52.39446 9.75344   17.27021  1.000 21.99086  ? 25  GLN A CB  1 
ATOM   293  C CG  . GLN B 2 27  ? 52.94936 10.56497  16.12383  1.000 20.78086  ? 25  GLN A CG  1 
ATOM   294  C CD  . GLN B 2 27  ? 54.41632 10.87320  16.32082  1.000 21.22086  ? 25  GLN A CD  1 
ATOM   295  O OE1 . GLN B 2 27  ? 54.86921 11.09320  17.45182  1.000 22.68086  ? 25  GLN A OE1 1 
ATOM   296  N NE2 . GLN B 2 27  ? 55.17406 10.88572  15.22638  1.000 22.62086  ? 25  GLN A NE2 1 
ATOM   297  N N   . ASN B 2 28  ? 53.42188 8.04941   19.66520  1.000 23.42902  ? 26  ASN A N   1 
ATOM   298  C CA  . ASN B 2 28  ? 53.23168 7.63891   21.05899  1.000 25.41902  ? 26  ASN A CA  1 
ATOM   299  C C   . ASN B 2 28  ? 53.20329 6.11591   21.20285  1.000 27.46902  ? 26  ASN A C   1 
ATOM   300  O O   . ASN B 2 28  ? 52.24552 5.51988   21.70301  1.000 22.31902  ? 26  ASN A O   1 
ATOM   301  C CB  . ASN B 2 28  ? 51.96835 8.27476   21.65050  1.000 29.84902  ? 26  ASN A CB  1 
ATOM   302  C CG  . ASN B 2 28  ? 52.02644 9.79893   21.65051  1.000 33.62902  ? 26  ASN A CG  1 
ATOM   303  O OD1 . ASN B 2 28  ? 53.10703 10.39442  21.69261  1.000 42.12902  ? 26  ASN A OD1 1 
ATOM   304  N ND2 . ASN B 2 28  ? 50.86441 10.43253  21.58965  1.000 33.62902  ? 26  ASN A ND2 1 
ATOM   305  N N   . LEU B 2 29  ? 54.28266 5.48950   20.75528  1.000 26.40608  ? 27  LEU A N   1 
ATOM   306  C CA  . LEU B 2 29  ? 54.35862 4.03818   20.81335  1.000 26.81608  ? 27  LEU A CA  1 
ATOM   307  C C   . LEU B 2 29  ? 54.62033 3.58858   22.24398  1.000 28.35608  ? 27  LEU A C   1 
ATOM   308  O O   . LEU B 2 29  ? 55.45103 4.16426   22.94867  1.000 26.73608  ? 27  LEU A O   1 
ATOM   309  C CB  . LEU B 2 29  ? 55.45807 3.51942   19.88362  1.000 24.52608  ? 27  LEU A CB  1 
ATOM   310  C CG  . LEU B 2 29  ? 55.15411 3.27987   18.40213  1.000 27.95608  ? 27  LEU A CG  1 
ATOM   311  C CD1 . LEU B 2 29  ? 54.83725 4.56564   17.66453  1.000 25.86608  ? 27  LEU A CD1 1 
ATOM   312  C CD2 . LEU B 2 29  ? 56.33579 2.57476   17.74485  1.000 29.67608  ? 27  LEU A CD2 1 
ATOM   313  N N   . SER B 2 30  ? 53.90373 2.55586   22.68087  1.000 28.40041  ? 28  SER A N   1 
ATOM   314  C CA  . SER B 2 30  ? 54.18408 2.04140   24.01046  1.000 32.39041  ? 28  SER A CA  1 
ATOM   315  C C   . SER B 2 30  ? 53.98848 0.53178   24.00286  1.000 30.97041  ? 28  SER A C   1 
ATOM   316  O O   . SER B 2 30  ? 52.96319 0.06142   23.48507  1.000 31.87041  ? 28  SER A O   1 
ATOM   317  C CB  . SER B 2 30  ? 53.28902 2.67711   25.07457  1.000 34.77041  ? 28  SER A CB  1 
ATOM   318  O OG  . SER B 2 30  ? 51.92468 2.37532   24.83867  1.000 33.76041  ? 28  SER A OG  1 
ATOM   319  N N   . PRO B 2 31  ? 54.93298 -0.23187  24.56245  1.000 37.62520  ? 29  PRO A N   1 
ATOM   320  C CA  . PRO B 2 31  ? 54.88420 -1.69705  24.44870  1.000 38.19520  ? 29  PRO A CA  1 
ATOM   321  C C   . PRO B 2 31  ? 53.66053 -2.32061  25.10614  1.000 40.28520  ? 29  PRO A C   1 
ATOM   322  O O   . PRO B 2 31  ? 53.24590 -1.93461  26.19967  1.000 38.93520  ? 29  PRO A O   1 
ATOM   323  C CB  . PRO B 2 31  ? 56.17199 -2.13988  25.14988  1.000 40.03520  ? 29  PRO A CB  1 
ATOM   324  C CG  . PRO B 2 31  ? 57.09356 -1.01007  24.94783  1.000 41.33520  ? 29  PRO A CG  1 
ATOM   325  C CD  . PRO B 2 31  ? 56.24865 0.22874   25.03681  1.000 38.20520  ? 29  PRO A CD  1 
ATOM   326  N N   . VAL B 2 32  ? 53.08159 -3.29752  24.41235  1.000 32.69304  ? 30  VAL A N   1 
ATOM   327  C CA  . VAL B 2 32  ? 51.95810 -4.05223  24.93302  1.000 40.21304  ? 30  VAL A CA  1 
ATOM   328  C C   . VAL B 2 32  ? 52.33535 -5.49577  25.25962  1.000 48.34304  ? 30  VAL A C   1 
ATOM   329  O O   . VAL B 2 32  ? 51.89424 -6.02192  26.28925  1.000 63.63304  ? 30  VAL A O   1 
ATOM   330  C CB  . VAL B 2 32  ? 50.77331 -3.99294  23.94149  1.000 41.66304  ? 30  VAL A CB  1 
ATOM   331  C CG1 . VAL B 2 32  ? 49.70461 -5.03754  24.25395  1.000 44.67304  ? 30  VAL A CG1 1 
ATOM   332  C CG2 . VAL B 2 32  ? 50.16054 -2.59999  23.95360  1.000 41.95304  ? 30  VAL A CG2 1 
ATOM   333  N N   . GLY B 2 33  ? 53.17898 -6.12930  24.45668  1.000 48.40179  ? 31  GLY A N   1 
ATOM   334  C CA  . GLY B 2 33  ? 53.55726 -7.50187  24.73676  1.000 59.07179  ? 31  GLY A CA  1 
ATOM   335  C C   . GLY B 2 33  ? 54.64522 -7.97281  23.79650  1.000 58.83179  ? 31  GLY A C   1 
ATOM   336  O O   . GLY B 2 33  ? 55.11707 -7.23238  22.92262  1.000 40.55179  ? 31  GLY A O   1 
ATOM   337  N N   . SER B 2 34  ? 55.04704 -9.22745  24.00724  1.000 59.38251  ? 32  SER A N   1 
ATOM   338  C CA  . SER B 2 34  ? 56.03340 -9.89588  23.16949  1.000 64.65251  ? 32  SER A CA  1 
ATOM   339  C C   . SER B 2 34  ? 55.68533 -11.37347 23.08556  1.000 68.80251  ? 32  SER A C   1 
ATOM   340  O O   . SER B 2 34  ? 55.38457 -12.00361 24.10533  1.000 61.94251  ? 32  SER A O   1 
ATOM   341  C CB  . SER B 2 34  ? 57.45783 -9.72207  23.71667  1.000 57.97251  ? 32  SER A CB  1 
ATOM   342  O OG  . SER B 2 34  ? 57.96273 -8.42600  23.44533  1.000 53.84251  ? 32  SER A OG  1 
ATOM   343  N N   . GLY B 2 35  ? 55.71114 -11.91011 21.86529  1.000 71.19678  ? 33  GLY A N   1 
ATOM   344  C CA  . GLY B 2 35  ? 55.64059 -13.33073 21.63260  1.000 66.89678  ? 33  GLY A CA  1 
ATOM   345  C C   . GLY B 2 35  ? 56.95735 -13.87748 21.11436  1.000 65.87678  ? 33  GLY A C   1 
ATOM   346  O O   . GLY B 2 35  ? 57.98369 -13.19470 21.08640  1.000 56.67678  ? 33  GLY A O   1 
ATOM   347  N N   . ALA B 2 36  ? 56.91438 -15.14622 20.70194  1.000 75.45488  ? 34  ALA A N   1 
ATOM   348  C CA  . ALA B 2 36  ? 58.08062 -15.75253 20.06969  1.000 69.40488  ? 34  ALA A CA  1 
ATOM   349  C C   . ALA B 2 36  ? 58.28433 -15.25094 18.64690  1.000 67.27488  ? 34  ALA A C   1 
ATOM   350  O O   . ALA B 2 36  ? 59.40396 -15.32544 18.13002  1.000 56.78488  ? 34  ALA A O   1 
ATOM   351  C CB  . ALA B 2 36  ? 57.95823 -17.27687 20.07084  1.000 66.50488  ? 34  ALA A CB  1 
ATOM   352  N N   . TYR B 2 37  ? 57.23825 -14.72646 18.00893  1.000 64.81523  ? 35  TYR A N   1 
ATOM   353  C CA  . TYR B 2 37  ? 57.30781 -14.33084 16.60949  1.000 60.15523  ? 35  TYR A CA  1 
ATOM   354  C C   . TYR B 2 37  ? 57.25922 -12.82081 16.40058  1.000 44.36523  ? 35  TYR A C   1 
ATOM   355  O O   . TYR B 2 37  ? 57.41065 -12.36891 15.25842  1.000 35.78523  ? 35  TYR A O   1 
ATOM   356  C CB  . TYR B 2 37  ? 56.18531 -15.01797 15.81658  1.000 69.42523  ? 35  TYR A CB  1 
ATOM   357  C CG  . TYR B 2 37  ? 56.21061 -16.53313 15.93948  1.000 82.83523  ? 35  TYR A CG  1 
ATOM   358  C CD1 . TYR B 2 37  ? 57.14413 -17.29504 15.23731  1.000 88.50523  ? 35  TYR A CD1 1 
ATOM   359  C CD2 . TYR B 2 37  ? 55.31005 -17.20090 16.76777  1.000 82.77523  ? 35  TYR A CD2 1 
ATOM   360  C CE1 . TYR B 2 37  ? 57.17565 -18.68013 15.35333  1.000 90.27523  ? 35  TYR A CE1 1 
ATOM   361  C CE2 . TYR B 2 37  ? 55.33263 -18.58645 16.88757  1.000 83.86523  ? 35  TYR A CE2 1 
ATOM   362  C CZ  . TYR B 2 37  ? 56.26723 -19.31829 16.17962  1.000 89.53523  ? 35  TYR A CZ  1 
ATOM   363  O OH  . TYR B 2 37  ? 56.29427 -20.68996 16.29608  1.000 96.95523  ? 35  TYR A OH  1 
ATOM   364  N N   . GLY B 2 38  ? 57.07610 -12.03142 17.45651  1.000 49.19258  ? 36  GLY A N   1 
ATOM   365  C CA  . GLY B 2 38  ? 57.11148 -10.58564 17.32112  1.000 45.65258  ? 36  GLY A CA  1 
ATOM   366  C C   . GLY B 2 38  ? 56.66303 -9.89028  18.58837  1.000 41.71258  ? 36  GLY A C   1 
ATOM   367  O O   . GLY B 2 38  ? 56.07692 -10.49518 19.49244  1.000 43.79258  ? 36  GLY A O   1 
ATOM   368  N N   . SER B 2 39  ? 56.94880 -8.58658  18.63662  1.000 41.33991  ? 37  SER A N   1 
ATOM   369  C CA  . SER B 2 39  ? 56.56147 -7.72299  19.74458  1.000 32.77991  ? 37  SER A CA  1 
ATOM   370  C C   . SER B 2 39  ? 55.62296 -6.62680  19.25382  1.000 28.28991  ? 37  SER A C   1 
ATOM   371  O O   . SER B 2 39  ? 55.65024 -6.23584  18.08059  1.000 24.05991  ? 37  SER A O   1 
ATOM   372  C CB  . SER B 2 39  ? 57.78550 -7.10292  20.42473  1.000 34.24991  ? 37  SER A CB  1 
ATOM   373  O OG  . SER B 2 39  ? 58.70466 -6.62266  19.46299  1.000 36.82991  ? 37  SER A OG  1 
ATOM   374  N N   . VAL B 2 40  ? 54.76904 -6.14825  20.15723  1.000 25.05479  ? 38  VAL A N   1 
ATOM   375  C CA  . VAL B 2 40  ? 53.63057 -5.30929  19.79836  1.000 25.20479  ? 38  VAL A CA  1 
ATOM   376  C C   . VAL B 2 40  ? 53.67597 -4.02551  20.61469  1.000 29.59479  ? 38  VAL A C   1 
ATOM   377  O O   . VAL B 2 40  ? 53.85284 -4.06877  21.83723  1.000 29.74479  ? 38  VAL A O   1 
ATOM   378  C CB  . VAL B 2 40  ? 52.29329 -6.04462  20.02197  1.000 26.56479  ? 38  VAL A CB  1 
ATOM   379  C CG1 . VAL B 2 40  ? 51.11454 -5.13976  19.68459  1.000 26.30479  ? 38  VAL A CG1 1 
ATOM   380  C CG2 . VAL B 2 40  ? 52.23373 -7.32184  19.18264  1.000 27.46479  ? 38  VAL A CG2 1 
ATOM   381  N N   . CYS B 2 41  ? 53.52351 -2.88663  19.93926  1.000 25.28839  ? 39  CYS A N   1 
ATOM   382  C CA  . CYS B 2 41  ? 53.30781 -1.60209  20.58825  1.000 24.73839  ? 39  CYS A CA  1 
ATOM   383  C C   . CYS B 2 41  ? 51.92732 -1.07655  20.23366  1.000 25.55839  ? 39  CYS A C   1 
ATOM   384  O O   . CYS B 2 41  ? 51.47960 -1.20574  19.09062  1.000 29.00839  ? 39  CYS A O   1 
ATOM   385  C CB  . CYS B 2 41  ? 54.34981 -0.57027  20.16112  1.000 26.04839  ? 39  CYS A CB  1 
ATOM   386  S SG  . CYS B 2 41  ? 55.97177 -0.86007  20.83674  1.000 32.85839  ? 39  CYS A SG  1 
ATOM   387  N N   . ALA B 2 42  ? 51.24863 -0.48479  21.20896  1.000 26.88573  ? 40  ALA A N   1 
ATOM   388  C CA  . ALA B 2 42  ? 50.11732 0.36314   20.87844  1.000 23.05573  ? 40  ALA A CA  1 
ATOM   389  C C   . ALA B 2 42  ? 50.64283 1.69188   20.34769  1.000 23.71573  ? 40  ALA A C   1 
ATOM   390  O O   . ALA B 2 42  ? 51.70531 2.16558   20.75599  1.000 28.01573  ? 40  ALA A O   1 
ATOM   391  C CB  . ALA B 2 42  ? 49.22886 0.59413   22.10168  1.000 25.23573  ? 40  ALA A CB  1 
ATOM   392  N N   . ALA B 2 43  ? 49.89657 2.29475   19.42859  1.000 22.39840  ? 41  ALA A N   1 
ATOM   393  C CA  . ALA B 2 43  ? 50.32402 3.56510   18.86041  1.000 23.02840  ? 41  ALA A CA  1 
ATOM   394  C C   . ALA B 2 43  ? 49.10080 4.35104   18.42970  1.000 22.07840  ? 41  ALA A C   1 
ATOM   395  O O   . ALA B 2 43  ? 48.02412 3.78913   18.21390  1.000 23.45840  ? 41  ALA A O   1 
ATOM   396  C CB  . ALA B 2 43  ? 51.26156 3.37386   17.65903  1.000 23.12840  ? 41  ALA A CB  1 
ATOM   397  N N   . PHE B 2 44  ? 49.28286 5.65983   18.27780  1.000 21.90345  ? 42  PHE A N   1 
ATOM   398  C CA  . PHE B 2 44  ? 48.24249 6.52210   17.73801  1.000 18.64345  ? 42  PHE A CA  1 
ATOM   399  C C   . PHE B 2 44  ? 48.49104 6.72079   16.24730  1.000 18.12345  ? 42  PHE A C   1 
ATOM   400  O O   . PHE B 2 44  ? 49.52271 7.27746   15.85515  1.000 19.66345  ? 42  PHE A O   1 
ATOM   401  C CB  . PHE B 2 44  ? 48.19274 7.86811   18.46801  1.000 21.51345  ? 42  PHE A CB  1 
ATOM   402  C CG  . PHE B 2 44  ? 47.11476 8.77225   17.95139  1.000 24.67345  ? 42  PHE A CG  1 
ATOM   403  C CD1 . PHE B 2 44  ? 45.77400 8.49123   18.21203  1.000 29.86345  ? 42  PHE A CD1 1 
ATOM   404  C CD2 . PHE B 2 44  ? 47.42346 9.86728   17.16600  1.000 26.97345  ? 42  PHE A CD2 1 
ATOM   405  C CE1 . PHE B 2 44  ? 44.77222 9.30295   17.70988  1.000 30.61345  ? 42  PHE A CE1 1 
ATOM   406  C CE2 . PHE B 2 44  ? 46.42506 10.68343  16.66215  1.000 25.72345  ? 42  PHE A CE2 1 
ATOM   407  C CZ  . PHE B 2 44  ? 45.10341 10.40285  16.93349  1.000 27.37345  ? 42  PHE A CZ  1 
ATOM   408  N N   . ASP B 2 45  ? 47.55431 6.25866   15.42184  1.000 18.03048  ? 43  ASP A N   1 
ATOM   409  C CA  . ASP B 2 45  ? 47.61792 6.45651   13.97752  1.000 20.24048  ? 43  ASP A CA  1 
ATOM   410  C C   . ASP B 2 45  ? 47.07351 7.84870   13.69422  1.000 23.76048  ? 43  ASP A C   1 
ATOM   411  O O   . ASP B 2 45  ? 45.85936 8.05782   13.66382  1.000 19.20048  ? 43  ASP A O   1 
ATOM   412  C CB  . ASP B 2 45  ? 46.82582 5.37135   13.24845  1.000 19.99048  ? 43  ASP A CB  1 
ATOM   413  C CG  . ASP B 2 45  ? 46.90300 5.48495   11.71610  1.000 22.53048  ? 43  ASP A CG  1 
ATOM   414  O OD1 . ASP B 2 45  ? 47.54858 6.41155   11.18565  1.000 25.73048  ? 43  ASP A OD1 1 
ATOM   415  O OD2 . ASP B 2 45  ? 46.31909 4.62376   11.01903  1.000 26.07048  ? 43  ASP A OD2 1 
ATOM   416  N N   . THR B 2 46  ? 47.97762 8.79820   13.43797  1.000 22.00295  ? 44  THR A N   1 
ATOM   417  C CA  . THR B 2 46  ? 47.57877 10.16259  13.11987  1.000 21.20295  ? 44  THR A CA  1 
ATOM   418  C C   . THR B 2 46  ? 46.87855 10.28659  11.77844  1.000 21.18295  ? 44  THR A C   1 
ATOM   419  O O   . THR B 2 46  ? 46.29474 11.33840  11.51332  1.000 21.75295  ? 44  THR A O   1 
ATOM   420  C CB  . THR B 2 46  ? 48.78962 11.11221  13.12305  1.000 22.23295  ? 44  THR A CB  1 
ATOM   421  O OG1 . THR B 2 46  ? 49.71210 10.72581  12.09806  1.000 22.89295  ? 44  THR A OG1 1 
ATOM   422  C CG2 . THR B 2 46  ? 49.48764 11.10583  14.46252  1.000 21.94295  ? 44  THR A CG2 1 
ATOM   423  N N   . LYS B 2 47  ? 46.93324 9.27036   10.91542  1.000 19.46661  ? 45  LYS A N   1 
ATOM   424  C CA  . LYS B 2 47  ? 46.21496 9.36552   9.64687   1.000 24.95661  ? 45  LYS A CA  1 
ATOM   425  C C   . LYS B 2 47  ? 44.72594 9.04163   9.81141   1.000 25.14661  ? 45  LYS A C   1 
ATOM   426  O O   . LYS B 2 47  ? 43.87071 9.72147   9.23292   1.000 21.79661  ? 45  LYS A O   1 
ATOM   427  C CB  . LYS B 2 47  ? 46.86127 8.44188   8.61229   1.000 31.11661  ? 45  LYS A CB  1 
ATOM   428  C CG  . LYS B 2 47  ? 46.20728 8.48670   7.23667   1.000 35.74661  ? 45  LYS A CG  1 
ATOM   429  C CD  . LYS B 2 47  ? 46.84280 7.48134   6.29531   1.000 40.95661  ? 45  LYS A CD  1 
ATOM   430  C CE  . LYS B 2 47  ? 46.07261 7.38124   4.98634   1.000 49.13661  ? 45  LYS A CE  1 
ATOM   431  N NZ  . LYS B 2 47  ? 44.73387 6.75710   5.17718   1.000 53.05661  ? 45  LYS A NZ  1 
ATOM   432  N N   . THR B 2 48  ? 44.39815 8.01787   10.59932  1.000 26.91332  ? 46  THR A N   1 
ATOM   433  C CA  . THR B 2 48  ? 43.01822 7.61602   10.84729  1.000 30.45332  ? 46  THR A CA  1 
ATOM   434  C C   . THR B 2 48  ? 42.46620 8.14507   12.16853  1.000 33.67332  ? 46  THR A C   1 
ATOM   435  O O   . THR B 2 48  ? 41.25565 8.04880   12.40039  1.000 34.64332  ? 46  THR A O   1 
ATOM   436  C CB  . THR B 2 48  ? 42.89045 6.08000   10.83886  1.000 27.10332  ? 46  THR A CB  1 
ATOM   437  O OG1 . THR B 2 48  ? 43.60806 5.52783   11.94942  1.000 27.26332  ? 46  THR A OG1 1 
ATOM   438  C CG2 . THR B 2 48  ? 43.44161 5.48775   9.55181   1.000 28.86332  ? 46  THR A CG2 1 
ATOM   439  N N   . GLY B 2 49  ? 43.30935 8.68681   13.04299  1.000 29.31522  ? 47  GLY A N   1 
ATOM   440  C CA  . GLY B 2 49  ? 42.82241 9.11050   14.34064  1.000 26.69522  ? 47  GLY A CA  1 
ATOM   441  C C   . GLY B 2 49  ? 42.48295 7.98889   15.29807  1.000 30.59522  ? 47  GLY A C   1 
ATOM   442  O O   . GLY B 2 49  ? 41.85167 8.24315   16.32627  1.000 35.08522  ? 47  GLY A O   1 
ATOM   443  N N   . HIS B 2 50  ? 42.88464 6.75680   15.00447  1.000 26.27290  ? 48  HIS A N   1 
ATOM   444  C CA  . HIS B 2 50  ? 42.59220 5.61410   15.85243  1.000 27.01290  ? 48  HIS A CA  1 
ATOM   445  C C   . HIS B 2 50  ? 43.86550 5.11736   16.51867  1.000 23.92290  ? 48  HIS A C   1 
ATOM   446  O O   . HIS B 2 50  ? 44.96964 5.30383   16.00191  1.000 20.80290  ? 48  HIS A O   1 
ATOM   447  C CB  . HIS B 2 50  ? 41.97084 4.47245   15.04444  1.000 33.15290  ? 48  HIS A CB  1 
ATOM   448  C CG  . HIS B 2 50  ? 40.70873 4.84619   14.33184  1.000 44.25290  ? 48  HIS A CG  1 
ATOM   449  N ND1 . HIS B 2 50  ? 39.71033 5.59410   14.91999  1.000 50.58290  ? 48  HIS A ND1 1 
ATOM   450  C CD2 . HIS B 2 50  ? 40.28279 4.57272   13.07587  1.000 47.22290  ? 48  HIS A CD2 1 
ATOM   451  C CE1 . HIS B 2 50  ? 38.72455 5.76605   14.05639  1.000 53.02290  ? 48  HIS A CE1 1 
ATOM   452  N NE2 . HIS B 2 50  ? 39.04732 5.15655   12.92957  1.000 52.12290  ? 48  HIS A NE2 1 
ATOM   453  N N   . ARG B 2 51  ? 43.70779 4.48438   17.67539  1.000 19.72686  ? 49  ARG A N   1 
ATOM   454  C CA  . ARG B 2 51  ? 44.80729 3.74348   18.26185  1.000 22.17686  ? 49  ARG A CA  1 
ATOM   455  C C   . ARG B 2 51  ? 44.90351 2.38869   17.57592  1.000 20.30686  ? 49  ARG A C   1 
ATOM   456  O O   . ARG B 2 51  ? 43.89063 1.78958   17.19874  1.000 20.92686  ? 49  ARG A O   1 
ATOM   457  C CB  . ARG B 2 51  ? 44.63331 3.58818   19.77248  1.000 28.29686  ? 49  ARG A CB  1 
ATOM   458  C CG  . ARG B 2 51  ? 44.84486 4.89802   20.51743  1.000 35.81686  ? 49  ARG A CG  1 
ATOM   459  C CD  . ARG B 2 51  ? 44.86464 4.72923   22.02360  1.000 42.16686  ? 49  ARG A CD  1 
ATOM   460  N NE  . ARG B 2 51  ? 46.18974 4.40083   22.53940  1.000 49.15686  ? 49  ARG A NE  1 
ATOM   461  C CZ  . ARG B 2 51  ? 46.47325 3.31506   23.24950  1.000 56.56686  ? 49  ARG A CZ  1 
ATOM   462  N NH1 . ARG B 2 51  ? 45.54781 2.40975   23.53134  1.000 53.50686  ? 49  ARG A NH1 1 
ATOM   463  N NH2 . ARG B 2 51  ? 47.71231 3.14230   23.70498  1.000 58.79686  ? 49  ARG A NH2 1 
ATOM   464  N N   . VAL B 2 52  ? 46.13829 1.92851   17.37571  1.000 20.63355  ? 50  VAL A N   1 
ATOM   465  C CA  . VAL B 2 52  ? 46.41372 0.75410   16.56452  1.000 20.14355  ? 50  VAL A CA  1 
ATOM   466  C C   . VAL B 2 52  ? 47.46367 -0.08475  17.27291  1.000 19.05355  ? 50  VAL A C   1 
ATOM   467  O O   . VAL B 2 52  ? 48.18021 0.38684   18.15935  1.000 22.89355  ? 50  VAL A O   1 
ATOM   468  C CB  . VAL B 2 52  ? 46.90709 1.12284   15.13975  1.000 18.98355  ? 50  VAL A CB  1 
ATOM   469  C CG1 . VAL B 2 52  ? 45.80414 1.80492   14.32793  1.000 20.14355  ? 50  VAL A CG1 1 
ATOM   470  C CG2 . VAL B 2 52  ? 48.15422 1.99504   15.22779  1.000 18.15355  ? 50  VAL A CG2 1 
ATOM   471  N N   . ALA B 2 53  ? 47.54081 -1.35004  16.88149  1.000 17.70496  ? 51  ALA A N   1 
ATOM   472  C CA  . ALA B 2 53  ? 48.62788 -2.21450  17.30978  1.000 16.68496  ? 51  ALA A CA  1 
ATOM   473  C C   . ALA B 2 53  ? 49.62493 -2.30257  16.16621  1.000 15.57496  ? 51  ALA A C   1 
ATOM   474  O O   . ALA B 2 53  ? 49.23666 -2.54059  15.01756  1.000 16.89496  ? 51  ALA A O   1 
ATOM   475  C CB  . ALA B 2 53  ? 48.12596 -3.60961  17.69121  1.000 18.31496  ? 51  ALA A CB  1 
ATOM   476  N N   . VAL B 2 54  ? 50.89616 -2.08831  16.48159  1.000 15.73226  ? 52  VAL A N   1 
ATOM   477  C CA  . VAL B 2 54  ? 51.99003 -2.18776  15.52479  1.000 17.16226  ? 52  VAL A CA  1 
ATOM   478  C C   . VAL B 2 54  ? 52.83419 -3.37144  15.96071  1.000 16.83226  ? 52  VAL A C   1 
ATOM   479  O O   . VAL B 2 54  ? 53.42236 -3.35013  17.04855  1.000 17.36226  ? 52  VAL A O   1 
ATOM   480  C CB  . VAL B 2 54  ? 52.82371 -0.89852  15.47115  1.000 18.09226  ? 52  VAL A CB  1 
ATOM   481  C CG1 . VAL B 2 54  ? 53.89629 -0.99688  14.37676  1.000 19.10226  ? 52  VAL A CG1 1 
ATOM   482  C CG2 . VAL B 2 54  ? 51.91388 0.31950   15.24081  1.000 18.94226  ? 52  VAL A CG2 1 
ATOM   483  N N   . LYS B 2 55  ? 52.87578 -4.41860  15.13993  1.000 16.49247  ? 53  LYS A N   1 
ATOM   484  C CA  . LYS B 2 55  ? 53.65748 -5.60576  15.46081  1.000 17.54247  ? 53  LYS A CA  1 
ATOM   485  C C   . LYS B 2 55  ? 54.92899 -5.60745  14.62431  1.000 16.88247  ? 53  LYS A C   1 
ATOM   486  O O   . LYS B 2 55  ? 54.86364 -5.55652  13.39292  1.000 15.39247  ? 53  LYS A O   1 
ATOM   487  C CB  . LYS B 2 55  ? 52.86798 -6.89255  15.21860  1.000 19.59247  ? 53  LYS A CB  1 
ATOM   488  C CG  . LYS B 2 55  ? 53.72978 -8.13249  15.43473  1.000 24.34247  ? 53  LYS A CG  1 
ATOM   489  C CD  . LYS B 2 55  ? 52.92057 -9.40258  15.65941  1.000 31.73247  ? 53  LYS A CD  1 
ATOM   490  C CE  . LYS B 2 55  ? 52.17293 -9.83549  14.41374  1.000 35.22247  ? 53  LYS A CE  1 
ATOM   491  N NZ  . LYS B 2 55  ? 51.40850 -11.09972 14.64543  1.000 42.09247  ? 53  LYS A NZ  1 
ATOM   492  N N   . LYS B 2 56  ? 56.07568 -5.63833  15.29126  1.000 16.58690  ? 54  LYS A N   1 
ATOM   493  C CA  . LYS B 2 56  ? 57.34882 -5.82821  14.62155  1.000 18.79690  ? 54  LYS A CA  1 
ATOM   494  C C   . LYS B 2 56  ? 57.68227 -7.30973  14.68977  1.000 19.35690  ? 54  LYS A C   1 
ATOM   495  O O   . LYS B 2 56  ? 57.79252 -7.87283  15.78413  1.000 17.46690  ? 54  LYS A O   1 
ATOM   496  C CB  . LYS B 2 56  ? 58.45498 -4.99744  15.26736  1.000 20.47690  ? 54  LYS A CB  1 
ATOM   497  C CG  . LYS B 2 56  ? 59.76217 -5.10892  14.50716  1.000 20.30690  ? 54  LYS A CG  1 
ATOM   498  C CD  . LYS B 2 56  ? 60.95688 -4.61196  15.29202  1.000 23.44690  ? 54  LYS A CD  1 
ATOM   499  C CE  . LYS B 2 56  ? 62.19919 -4.66092  14.40106  1.000 25.43690  ? 54  LYS A CE  1 
ATOM   500  N NZ  . LYS B 2 56  ? 63.35768 -3.95818  14.99064  1.000 28.93690  ? 54  LYS A NZ  1 
ATOM   501  N N   . LEU B 2 57  ? 57.79994 -7.95349  13.53396  1.000 19.20680  ? 55  LEU A N   1 
ATOM   502  C CA  . LEU B 2 57  ? 58.08245 -9.38303  13.54950  1.000 23.11680  ? 55  LEU A CA  1 
ATOM   503  C C   . LEU B 2 57  ? 59.50802 -9.62710  14.02964  1.000 20.73680  ? 55  LEU A C   1 
ATOM   504  O O   . LEU B 2 57  ? 60.43693 -8.89072  13.68184  1.000 21.88680  ? 55  LEU A O   1 
ATOM   505  C CB  . LEU B 2 57  ? 57.86500 -9.99232  12.16505  1.000 23.30680  ? 55  LEU A CB  1 
ATOM   506  C CG  . LEU B 2 57  ? 56.41682 -10.01043 11.67564  1.000 23.09680  ? 55  LEU A CG  1 
ATOM   507  C CD1 . LEU B 2 57  ? 56.33901 -10.79822 10.38533  1.000 24.58680  ? 55  LEU A CD1 1 
ATOM   508  C CD2 . LEU B 2 57  ? 55.46454 -10.59415 12.71149  1.000 23.95680  ? 55  LEU A CD2 1 
ATOM   509  N N   . SER B 2 58  ? 59.67679 -10.65631 14.84772  1.000 26.87080  ? 56  SER A N   1 
ATOM   510  C CA  . SER B 2 58  ? 60.98360 -10.98537 15.40467  1.000 33.67080  ? 56  SER A CA  1 
ATOM   511  C C   . SER B 2 58  ? 61.71613 -11.91143 14.43970  1.000 31.09080  ? 56  SER A C   1 
ATOM   512  O O   . SER B 2 58  ? 61.30035 -13.05984 14.24616  1.000 28.26080  ? 56  SER A O   1 
ATOM   513  C CB  . SER B 2 58  ? 60.83998 -11.63596 16.77746  1.000 37.95080  ? 56  SER A CB  1 
ATOM   514  O OG  . SER B 2 58  ? 62.11815 -11.88349 17.33845  1.000 44.69080  ? 56  SER A OG  1 
ATOM   515  N N   . ARG B 2 59  ? 62.82845 -11.40518 13.86307  1.000 29.36854  ? 57  ARG A N   1 
ATOM   516  C CA  . ARG B 2 59  ? 63.72561 -12.03639 12.89004  1.000 39.81854  ? 57  ARG A CA  1 
ATOM   517  C C   . ARG B 2 59  ? 62.93277 -12.85621 11.87634  1.000 31.99854  ? 57  ARG A C   1 
ATOM   518  O O   . ARG B 2 59  ? 63.00645 -14.09459 11.86815  1.000 24.60854  ? 57  ARG A O   1 
ATOM   519  C CB  . ARG B 2 59  ? 64.76974 -12.89359 13.61094  1.000 48.33854  ? 57  ARG A CB  1 
ATOM   520  C CG  . ARG B 2 59  ? 65.74302 -12.07215 14.45212  1.000 52.68854  ? 57  ARG A CG  1 
ATOM   521  C CD  . ARG B 2 59  ? 66.64484 -12.97590 15.27371  1.000 58.57854  ? 57  ARG A CD  1 
ATOM   522  N NE  . ARG B 2 59  ? 65.87644 -13.82654 16.17557  1.000 69.71854  ? 57  ARG A NE  1 
ATOM   523  C CZ  . ARG B 2 59  ? 66.26347 -15.02710 16.58538  1.000 80.50854  ? 57  ARG A CZ  1 
ATOM   524  N NH1 . ARG B 2 59  ? 67.39653 -15.56835 16.16636  1.000 76.50854  ? 57  ARG A NH1 1 
ATOM   525  N NH2 . ARG B 2 59  ? 65.48978 -15.70549 17.42953  1.000 84.83854  ? 57  ARG A NH2 1 
ATOM   526  N N   . PRO B 2 60  ? 62.13609 -12.19677 11.03176  1.000 25.90050  ? 58  PRO A N   1 
ATOM   527  C CA  . PRO B 2 60  ? 61.13734 -12.93127 10.24235  1.000 22.55050  ? 58  PRO A CA  1 
ATOM   528  C C   . PRO B 2 60  ? 61.73240 -13.88521 9.22037   1.000 17.11050  ? 58  PRO A C   1 
ATOM   529  O O   . PRO B 2 60  ? 61.02999 -14.79455 8.78022   1.000 19.00050  ? 58  PRO A O   1 
ATOM   530  C CB  . PRO B 2 60  ? 60.35081 -11.80858 9.55812   1.000 21.27050  ? 58  PRO A CB  1 
ATOM   531  C CG  . PRO B 2 60  ? 61.34030 -10.67062 9.47744   1.000 22.34050  ? 58  PRO A CG  1 
ATOM   532  C CD  . PRO B 2 60  ? 62.14195 -10.75355 10.72458  1.000 25.76050  ? 58  PRO A CD  1 
ATOM   533  N N   . PHE B 2 61  ? 62.99182 -13.71244 8.84103   1.000 18.24232  ? 59  PHE A N   1 
ATOM   534  C CA  . PHE B 2 61  ? 63.62405 -14.49479 7.78482   1.000 21.32232  ? 59  PHE A CA  1 
ATOM   535  C C   . PHE B 2 61  ? 64.82974 -15.25018 8.32630   1.000 28.86232  ? 59  PHE A C   1 
ATOM   536  O O   . PHE B 2 61  ? 65.81619 -15.47128 7.61424   1.000 27.85232  ? 59  PHE A O   1 
ATOM   537  C CB  . PHE B 2 61  ? 64.00436 -13.58530 6.62248   1.000 20.89232  ? 59  PHE A CB  1 
ATOM   538  C CG  . PHE B 2 61  ? 62.87032 -12.70684 6.17182   1.000 17.31232  ? 59  PHE A CG  1 
ATOM   539  C CD1 . PHE B 2 61  ? 61.71410 -13.27655 5.65572   1.000 17.85232  ? 59  PHE A CD1 1 
ATOM   540  C CD2 . PHE B 2 61  ? 62.93857 -11.32570 6.30540   1.000 19.29232  ? 59  PHE A CD2 1 
ATOM   541  C CE1 . PHE B 2 61  ? 60.64857 -12.47429 5.24625   1.000 15.45232  ? 59  PHE A CE1 1 
ATOM   542  C CE2 . PHE B 2 61  ? 61.88097 -10.51619 5.90769   1.000 18.02232  ? 59  PHE A CE2 1 
ATOM   543  C CZ  . PHE B 2 61  ? 60.73899 -11.09555 5.36927   1.000 16.65232  ? 59  PHE A CZ  1 
ATOM   544  N N   . GLN B 2 62  ? 64.73268 -15.64618 9.60000   1.000 27.45944  ? 60  GLN A N   1 
ATOM   545  C CA  . GLN B 2 62  ? 65.81955 -16.33730 10.28718  1.000 34.65944  ? 60  GLN A CA  1 
ATOM   546  C C   . GLN B 2 62  ? 66.09538 -17.69733 9.66305   1.000 28.21944  ? 60  GLN A C   1 
ATOM   547  O O   . GLN B 2 62  ? 67.25792 -18.08314 9.50399   1.000 27.68944  ? 60  GLN A O   1 
ATOM   548  C CB  . GLN B 2 62  ? 65.47500 -16.48917 11.77188  1.000 36.31944  ? 60  GLN A CB  1 
ATOM   549  C CG  . GLN B 2 62  ? 66.28838 -17.54843 12.50309  1.000 52.58944  ? 60  GLN A CG  1 
ATOM   550  C CD  . GLN B 2 62  ? 65.62475 -18.02353 13.78147  1.000 58.32944  ? 60  GLN A CD  1 
ATOM   551  O OE1 . GLN B 2 62  ? 65.03879 -17.23262 14.52007  1.000 65.10944  ? 60  GLN A OE1 1 
ATOM   552  N NE2 . GLN B 2 62  ? 65.70569 -19.32670 14.04344  1.000 56.66944  ? 60  GLN A NE2 1 
ATOM   553  N N   . SER B 2 63  ? 65.03949 -18.42622 9.29492   1.000 28.77134  ? 61  SER A N   1 
ATOM   554  C CA  . SER B 2 63  ? 65.13243 -19.74535 8.68185   1.000 25.50134  ? 61  SER A CA  1 
ATOM   555  C C   . SER B 2 63  ? 64.09653 -19.85405 7.57002   1.000 22.87134  ? 61  SER A C   1 
ATOM   556  O O   . SER B 2 63  ? 63.30850 -18.92836 7.34354   1.000 19.62134  ? 61  SER A O   1 
ATOM   557  C CB  . SER B 2 63  ? 64.87824 -20.84589 9.70363   1.000 26.26134  ? 61  SER A CB  1 
ATOM   558  O OG  . SER B 2 63  ? 63.54391 -20.75273 10.16765  1.000 23.39134  ? 61  SER A OG  1 
ATOM   559  N N   . ILE B 2 64  ? 64.07499 -21.01659 6.90414   1.000 19.25542  ? 62  ILE A N   1 
ATOM   560  C CA  . ILE B 2 64  ? 63.02134 -21.31166 5.93224   1.000 20.87542  ? 62  ILE A CA  1 
ATOM   561  C C   . ILE B 2 64  ? 61.66287 -21.31779 6.61476   1.000 19.80542  ? 62  ILE A C   1 
ATOM   562  O O   . ILE B 2 64  ? 60.69411 -20.74698 6.10624   1.000 16.08542  ? 62  ILE A O   1 
ATOM   563  C CB  . ILE B 2 64  ? 63.28484 -22.65484 5.22578   1.000 19.45542  ? 62  ILE A CB  1 
ATOM   564  C CG1 . ILE B 2 64  ? 64.42595 -22.53412 4.21726   1.000 23.21542  ? 62  ILE A CG1 1 
ATOM   565  C CG2 . ILE B 2 64  ? 62.03567 -23.15519 4.50460   1.000 20.03542  ? 62  ILE A CG2 1 
ATOM   566  C CD1 . ILE B 2 64  ? 64.95460 -23.87373 3.77175   1.000 25.95542  ? 62  ILE A CD1 1 
ATOM   567  N N   . ILE B 2 65  ? 61.57570 -21.96752 7.77837   1.000 18.93531  ? 63  ILE A N   1 
ATOM   568  C CA  . ILE B 2 65  ? 60.29969 -22.08497 8.48520   1.000 22.25531  ? 63  ILE A CA  1 
ATOM   569  C C   . ILE B 2 65  ? 59.76828 -20.71055 8.88730   1.000 19.15531  ? 63  ILE A C   1 
ATOM   570  O O   . ILE B 2 65  ? 58.58347 -20.41507 8.69925   1.000 18.25531  ? 63  ILE A O   1 
ATOM   571  C CB  . ILE B 2 65  ? 60.45211 -23.02038 9.69975   1.000 28.40531  ? 63  ILE A CB  1 
ATOM   572  C CG1 . ILE B 2 65  ? 60.82497 -24.42420 9.23126   1.000 31.19531  ? 63  ILE A CG1 1 
ATOM   573  C CG2 . ILE B 2 65  ? 59.17253 -23.07842 10.50868  1.000 31.24531  ? 63  ILE A CG2 1 
ATOM   574  C CD1 . ILE B 2 65  ? 61.21380 -25.33972 10.35907  1.000 34.43531  ? 63  ILE A CD1 1 
ATOM   575  N N   . HIS B 2 66  ? 60.63833 -19.83805 9.40012   1.000 18.09018  ? 64  HIS A N   1 
ATOM   576  C CA  . HIS B 2 66  ? 60.20322 -18.50770 9.81301   1.000 20.45018  ? 64  HIS A CA  1 
ATOM   577  C C   . HIS B 2 66  ? 59.82775 -17.63702 8.61496   1.000 17.70018  ? 64  HIS A C   1 
ATOM   578  O O   . HIS B 2 66  ? 58.85670 -16.86750 8.67622   1.000 15.78018  ? 64  HIS A O   1 
ATOM   579  C CB  . HIS B 2 66  ? 61.30374 -17.83216 10.62977  1.000 24.80018  ? 64  HIS A CB  1 
ATOM   580  C CG  . HIS B 2 66  ? 61.46174 -18.40114 12.00705  1.000 33.64018  ? 64  HIS A CG  1 
ATOM   581  N ND1 . HIS B 2 66  ? 62.00128 -17.68437 13.05229  1.000 42.70018  ? 64  HIS A ND1 1 
ATOM   582  C CD2 . HIS B 2 66  ? 61.14375 -19.61762 12.50926  1.000 38.37018  ? 64  HIS A CD2 1 
ATOM   583  C CE1 . HIS B 2 66  ? 62.01055 -18.43585 14.13888  1.000 43.13018  ? 64  HIS A CE1 1 
ATOM   584  N NE2 . HIS B 2 66  ? 61.49275 -19.61275 13.83681  1.000 40.57018  ? 64  HIS A NE2 1 
ATOM   585  N N   . ALA B 2 67  ? 60.62494 -17.69961 7.54669   1.000 14.96077  ? 65  ALA A N   1 
ATOM   586  C CA  . ALA B 2 67  ? 60.34110 -16.92362 6.34411   1.000 14.13077  ? 65  ALA A CA  1 
ATOM   587  C C   . ALA B 2 67  ? 59.00151 -17.32134 5.72603   1.000 11.82077  ? 65  ALA A C   1 
ATOM   588  O O   . ALA B 2 67  ? 58.20346 -16.46130 5.34458   1.000 11.76077  ? 65  ALA A O   1 
ATOM   589  C CB  . ALA B 2 67  ? 61.48260 -17.10560 5.34687   1.000 12.85077  ? 65  ALA A CB  1 
ATOM   590  N N   . LYS B 2 68  ? 58.73383 -18.61863 5.63146   1.000 10.98435  ? 66  LYS A N   1 
ATOM   591  C CA  . LYS B 2 68  ? 57.45615 -19.06534 5.09516   1.000 12.43435  ? 66  LYS A CA  1 
ATOM   592  C C   . LYS B 2 68  ? 56.30066 -18.67277 6.01006   1.000 12.81435  ? 66  LYS A C   1 
ATOM   593  O O   . LYS B 2 68  ? 55.21498 -18.31929 5.53440   1.000 8.84435   ? 66  LYS A O   1 
ATOM   594  C CB  . LYS B 2 68  ? 57.49509 -20.57073 4.89127   1.000 12.92435  ? 66  LYS A CB  1 
ATOM   595  C CG  . LYS B 2 68  ? 56.23258 -21.14671 4.33395   1.000 14.58435  ? 66  LYS A CG  1 
ATOM   596  C CD  . LYS B 2 68  ? 56.43956 -22.58962 3.91857   1.000 18.57435  ? 66  LYS A CD  1 
ATOM   597  C CE  . LYS B 2 68  ? 55.19156 -23.15335 3.26840   1.000 20.57435  ? 66  LYS A CE  1 
ATOM   598  N NZ  . LYS B 2 68  ? 55.40434 -24.52483 2.76620   1.000 24.64435  ? 66  LYS A NZ  1 
ATOM   599  N N   . ARG B 2 69  ? 56.51846 -18.73834 7.32932   1.000 14.93082  ? 67  ARG A N   1 
ATOM   600  C CA  . ARG B 2 69  ? 55.49662 -18.31808 8.28545   1.000 15.70082  ? 67  ARG A CA  1 
ATOM   601  C C   . ARG B 2 69  ? 55.19010 -16.83577 8.14653   1.000 12.04082  ? 67  ARG A C   1 
ATOM   602  O O   . ARG B 2 69  ? 54.02975 -16.42355 8.26718   1.000 11.50082  ? 67  ARG A O   1 
ATOM   603  C CB  . ARG B 2 69  ? 55.95447 -18.62207 9.71780   1.000 21.70082  ? 67  ARG A CB  1 
ATOM   604  C CG  . ARG B 2 69  ? 54.88698 -18.34301 10.77047  1.000 32.81082  ? 67  ARG A CG  1 
ATOM   605  C CD  . ARG B 2 69  ? 55.45745 -18.32853 12.17563  1.000 45.44082  ? 67  ARG A CD  1 
ATOM   606  N NE  . ARG B 2 69  ? 54.41673 -18.54743 13.17457  1.000 62.69082  ? 67  ARG A NE  1 
ATOM   607  C CZ  . ARG B 2 69  ? 53.72822 -17.58271 13.77078  1.000 71.30082  ? 67  ARG A CZ  1 
ATOM   608  N NH1 . ARG B 2 69  ? 53.95897 -16.30557 13.51007  1.000 76.27082  ? 67  ARG A NH1 1 
ATOM   609  N NH2 . ARG B 2 69  ? 52.78949 -17.90768 14.65638  1.000 70.87082  ? 67  ARG A NH2 1 
ATOM   610  N N   . THR B 2 70  ? 56.22134 -16.02413 7.90472   1.000 11.65936  ? 68  THR A N   1 
ATOM   611  C CA  . THR B 2 70  ? 56.03039 -14.59373 7.68394   1.000 12.81936  ? 68  THR A CA  1 
ATOM   612  C C   . THR B 2 70  ? 55.18476 -14.33644 6.44155   1.000 11.80936  ? 68  THR A C   1 
ATOM   613  O O   . THR B 2 70  ? 54.24379 -13.53207 6.46755   1.000 9.65936   ? 68  THR A O   1 
ATOM   614  C CB  . THR B 2 70  ? 57.39308 -13.92022 7.54754   1.000 13.12936  ? 68  THR A CB  1 
ATOM   615  O OG1 . THR B 2 70  ? 58.10515 -14.05776 8.78424   1.000 13.46936  ? 68  THR A OG1 1 
ATOM   616  C CG2 . THR B 2 70  ? 57.24319 -12.45263 7.19111   1.000 13.00936  ? 68  THR A CG2 1 
ATOM   617  N N   . TYR B 2 71  ? 55.51577 -15.02108 5.34005   1.000 11.00903  ? 69  TYR A N   1 
ATOM   618  C CA  . TYR B 2 71  ? 54.74925 -14.89611 4.10276   1.000 9.67903   ? 69  TYR A CA  1 
ATOM   619  C C   . TYR B 2 71  ? 53.30645 -15.34029 4.30166   1.000 10.40903  ? 69  TYR A C   1 
ATOM   620  O O   . TYR B 2 71  ? 52.37100 -14.64882 3.87635   1.000 8.69903   ? 69  TYR A O   1 
ATOM   621  C CB  . TYR B 2 71  ? 55.42270 -15.72684 3.00918   1.000 9.76903   ? 69  TYR A CB  1 
ATOM   622  C CG  . TYR B 2 71  ? 54.68395 -15.69603 1.70289   1.000 9.46903   ? 69  TYR A CG  1 
ATOM   623  C CD1 . TYR B 2 71  ? 54.77480 -14.59005 0.86797   1.000 10.20903  ? 69  TYR A CD1 1 
ATOM   624  C CD2 . TYR B 2 71  ? 53.90882 -16.77773 1.29614   1.000 9.37903   ? 69  TYR A CD2 1 
ATOM   625  C CE1 . TYR B 2 71  ? 54.11087 -14.56392 -0.35088  1.000 10.79903  ? 69  TYR A CE1 1 
ATOM   626  C CE2 . TYR B 2 71  ? 53.22667 -16.75100 0.07931   1.000 11.07903  ? 69  TYR A CE2 1 
ATOM   627  C CZ  . TYR B 2 71  ? 53.33739 -15.64367 -0.73265  1.000 11.58903  ? 69  TYR A CZ  1 
ATOM   628  O OH  . TYR B 2 71  ? 52.66455 -15.61419 -1.93367  1.000 11.55903  ? 69  TYR A OH  1 
ATOM   629  N N   . ARG B 2 72  ? 53.11213 -16.48833 4.97528   1.000 9.35925   ? 70  ARG A N   1 
ATOM   630  C CA  . ARG B 2 72  ? 51.77210 -17.00278 5.25721   1.000 10.88925  ? 70  ARG A CA  1 
ATOM   631  C C   . ARG B 2 72  ? 50.93077 -16.00236 6.04479   1.000 10.98925  ? 70  ARG A C   1 
ATOM   632  O O   . ARG B 2 72  ? 49.75849 -15.78612 5.71923   1.000 9.44925   ? 70  ARG A O   1 
ATOM   633  C CB  . ARG B 2 72  ? 51.86396 -18.32129 6.03602   1.000 12.59925  ? 70  ARG A CB  1 
ATOM   634  C CG  . ARG B 2 72  ? 50.50782 -18.89191 6.46273   1.000 15.64925  ? 70  ARG A CG  1 
ATOM   635  C CD  . ARG B 2 72  ? 50.65327 -20.10031 7.41272   1.000 20.51925  ? 70  ARG A CD  1 
ATOM   636  N NE  . ARG B 2 72  ? 51.37808 -21.19561 6.78668   1.000 20.95925  ? 70  ARG A NE  1 
ATOM   637  C CZ  . ARG B 2 72  ? 52.59165 -21.59855 7.13777   1.000 21.17925  ? 70  ARG A CZ  1 
ATOM   638  N NH1 . ARG B 2 72  ? 53.20437 -21.10406 8.19776   1.000 25.56925  ? 70  ARG A NH1 1 
ATOM   639  N NH2 . ARG B 2 72  ? 53.20944 -22.51270 6.39560   1.000 21.75925  ? 70  ARG A NH2 1 
ATOM   640  N N   . GLU B 2 73  ? 51.51458 -15.37022 7.06884   1.000 11.90420  ? 71  GLU A N   1 
ATOM   641  C CA  . GLU B 2 73  ? 50.75179 -14.41600 7.87391   1.000 13.75420  ? 71  GLU A CA  1 
ATOM   642  C C   . GLU B 2 73  ? 50.37727 -13.18659 7.05852   1.000 12.52420  ? 71  GLU A C   1 
ATOM   643  O O   . GLU B 2 73  ? 49.24441 -12.69471 7.14800   1.000 10.63420  ? 71  GLU A O   1 
ATOM   644  C CB  . GLU B 2 73  ? 51.53684 -13.98377 9.12045   1.000 16.91420  ? 71  GLU A CB  1 
ATOM   645  C CG  . GLU B 2 73  ? 50.77174 -12.92945 9.94690   1.000 19.98420  ? 71  GLU A CG  1 
ATOM   646  C CD  . GLU B 2 73  ? 51.40900 -12.55119 11.28721  1.000 27.03420  ? 71  GLU A CD  1 
ATOM   647  O OE1 . GLU B 2 73  ? 52.61692 -12.79752 11.49068  1.000 30.92420  ? 71  GLU A OE1 1 
ATOM   648  O OE2 . GLU B 2 73  ? 50.68552 -11.98095 12.14325  1.000 30.28420  ? 71  GLU A OE2 1 
ATOM   649  N N   . LEU B 2 74  ? 51.31922 -12.67363 6.26323   1.000 11.08050  ? 72  LEU A N   1 
ATOM   650  C CA  . LEU B 2 74  ? 51.03471 -11.48848 5.46070   1.000 10.94050  ? 72  LEU A CA  1 
ATOM   651  C C   . LEU B 2 74  ? 49.99575 -11.78129 4.38123   1.000 9.04050   ? 72  LEU A C   1 
ATOM   652  O O   . LEU B 2 74  ? 49.08936 -10.97077 4.16214   1.000 9.91050   ? 72  LEU A O   1 
ATOM   653  C CB  . LEU B 2 74  ? 52.33109 -10.94524 4.86059   1.000 11.94050  ? 72  LEU A CB  1 
ATOM   654  C CG  . LEU B 2 74  ? 52.29629 -9.63314  4.06842   1.000 14.09050  ? 72  LEU A CG  1 
ATOM   655  C CD1 . LEU B 2 74  ? 51.63286 -8.51027  4.87510   1.000 15.76050  ? 72  LEU A CD1 1 
ATOM   656  C CD2 . LEU B 2 74  ? 53.71822 -9.26406  3.68217   1.000 14.77050  ? 72  LEU A CD2 1 
ATOM   657  N N   . ARG B 2 75  ? 50.10462 -12.92888 3.70365   1.000 8.91875   ? 73  ARG A N   1 
ATOM   658  C CA  . ARG B 2 75  ? 49.09445 -13.32270 2.72362   1.000 9.72875   ? 73  ARG A CA  1 
ATOM   659  C C   . ARG B 2 75  ? 47.71969 -13.44496 3.37201   1.000 9.38875   ? 73  ARG A C   1 
ATOM   660  O O   . ARG B 2 75  ? 46.72202 -12.97081 2.81973   1.000 7.59875   ? 73  ARG A O   1 
ATOM   661  C CB  . ARG B 2 75  ? 49.47975 -14.64684 2.06016   1.000 10.10875  ? 73  ARG A CB  1 
ATOM   662  C CG  . ARG B 2 75  ? 50.54789 -14.53959 0.95209   1.000 10.65875  ? 73  ARG A CG  1 
ATOM   663  C CD  . ARG B 2 75  ? 50.02800 -13.86024 -0.31264  1.000 10.92875  ? 73  ARG A CD  1 
ATOM   664  N NE  . ARG B 2 75  ? 48.79833 -14.46504 -0.81104  1.000 11.55875  ? 73  ARG A NE  1 
ATOM   665  C CZ  . ARG B 2 75  ? 48.72646 -15.61921 -1.46702  1.000 12.09875  ? 73  ARG A CZ  1 
ATOM   666  N NH1 . ARG B 2 75  ? 49.80921 -16.29739 -1.80023  1.000 13.11875  ? 73  ARG A NH1 1 
ATOM   667  N NH2 . ARG B 2 75  ? 47.52986 -16.12077 -1.77798  1.000 12.67875  ? 73  ARG A NH2 1 
ATOM   668  N N   . LEU B 2 76  ? 47.65699 -14.07688 4.55008   1.000 9.35370   ? 74  LEU A N   1 
ATOM   669  C CA  . LEU B 2 76  ? 46.39379 -14.19972 5.27835   1.000 10.17370  ? 74  LEU A CA  1 
ATOM   670  C C   . LEU B 2 76  ? 45.81183 -12.83123 5.63997   1.000 9.36370   ? 74  LEU A C   1 
ATOM   671  O O   . LEU B 2 76  ? 44.64136 -12.54801 5.36204   1.000 9.27370   ? 74  LEU A O   1 
ATOM   672  C CB  . LEU B 2 76  ? 46.60872 -15.03676 6.53943   1.000 11.93370  ? 74  LEU A CB  1 
ATOM   673  C CG  . LEU B 2 76  ? 45.32460 -15.32982 7.31046   1.000 15.65370  ? 74  LEU A CG  1 
ATOM   674  C CD1 . LEU B 2 76  ? 44.37207 -16.14082 6.44760   1.000 18.15370  ? 74  LEU A CD1 1 
ATOM   675  C CD2 . LEU B 2 76  ? 45.64039 -16.08240 8.58721   1.000 20.11370  ? 74  LEU A CD2 1 
ATOM   676  N N   . LEU B 2 77  ? 46.61275 -11.97285 6.26551   1.000 9.54574   ? 75  LEU A N   1 
ATOM   677  C CA  . LEU B 2 77  ? 46.10593 -10.68129 6.72876   1.000 10.84574  ? 75  LEU A CA  1 
ATOM   678  C C   . LEU B 2 77  ? 45.69295 -9.77739  5.57325   1.000 11.58574  ? 75  LEU A C   1 
ATOM   679  O O   . LEU B 2 77  ? 44.73316 -9.00038  5.70120   1.000 12.76574  ? 75  LEU A O   1 
ATOM   680  C CB  . LEU B 2 77  ? 47.16005 -9.98876  7.59500   1.000 13.42574  ? 75  LEU A CB  1 
ATOM   681  C CG  . LEU B 2 77  ? 47.41534 -10.64230 8.95671   1.000 16.10574  ? 75  LEU A CG  1 
ATOM   682  C CD1 . LEU B 2 77  ? 48.58389 -9.98916  9.66156   1.000 18.85574  ? 75  LEU A CD1 1 
ATOM   683  C CD2 . LEU B 2 77  ? 46.17252 -10.60342 9.84256   1.000 20.87574  ? 75  LEU A CD2 1 
ATOM   684  N N   . LYS B 2 78  ? 46.40033 -9.86120  4.43710   1.000 11.73282  ? 76  LYS A N   1 
ATOM   685  C CA  . LYS B 2 78  ? 46.03147 -9.06116  3.27466   1.000 11.03282  ? 76  LYS A CA  1 
ATOM   686  C C   . LYS B 2 78  ? 44.71179 -9.51891  2.66415   1.000 11.58282  ? 76  LYS A C   1 
ATOM   687  O O   . LYS B 2 78  ? 44.04110 -8.73735  1.98622   1.000 12.23282  ? 76  LYS A O   1 
ATOM   688  C CB  . LYS B 2 78  ? 47.14201 -9.12364  2.21081   1.000 10.94282  ? 76  LYS A CB  1 
ATOM   689  C CG  . LYS B 2 78  ? 48.35008 -8.24301  2.51759   1.000 12.98282  ? 76  LYS A CG  1 
ATOM   690  C CD  . LYS B 2 78  ? 49.37114 -8.27866  1.37529   1.000 14.29282  ? 76  LYS A CD  1 
ATOM   691  C CE  . LYS B 2 78  ? 48.86444 -7.56631  0.13006   1.000 14.31282  ? 76  LYS A CE  1 
ATOM   692  N NZ  . LYS B 2 78  ? 49.90414 -7.61802  -0.96908  1.000 15.56282  ? 76  LYS A NZ  1 
ATOM   693  N N   . HIS B 2 79  ? 44.32591 -10.77228 2.87114   1.000 11.81135  ? 77  HIS A N   1 
ATOM   694  C CA  . HIS B 2 79  ? 43.13109 -11.27069 2.21682   1.000 12.48135  ? 77  HIS A CA  1 
ATOM   695  C C   . HIS B 2 79  ? 41.85326 -10.85680 2.93358   1.000 13.08135  ? 77  HIS A C   1 
ATOM   696  O O   . HIS B 2 79  ? 40.81944 -10.64925 2.28648   1.000 12.61135  ? 77  HIS A O   1 
ATOM   697  C CB  . HIS B 2 79  ? 43.18760 -12.78809 2.12627   1.000 13.65135  ? 77  HIS A CB  1 
ATOM   698  C CG  . HIS B 2 79  ? 42.10601 -13.36780 1.27678   1.000 15.96135  ? 77  HIS A CG  1 
ATOM   699  N ND1 . HIS B 2 79  ? 42.14697 -13.33223 -0.10356  1.000 16.50135  ? 77  HIS A ND1 1 
ATOM   700  C CD2 . HIS B 2 79  ? 40.94297 -13.98224 1.60768   1.000 14.63135  ? 77  HIS A CD2 1 
ATOM   701  C CE1 . HIS B 2 79  ? 41.06314 -13.91640 -0.58546  1.000 17.62135  ? 77  HIS A CE1 1 
ATOM   702  N NE2 . HIS B 2 79  ? 40.31556 -14.31522 0.43154   1.000 15.98135  ? 77  HIS A NE2 1 
ATOM   703  N N   . MET B 2 80  ? 41.88679 -10.77259 4.25944   1.000 12.32594  ? 78  MET A N   1 
ATOM   704  C CA  . MET B 2 80  ? 40.66427 -10.75650 5.05889   1.000 14.19594  ? 78  MET A CA  1 
ATOM   705  C C   . MET B 2 80  ? 40.11537 -9.34080  5.18126   1.000 11.96594  ? 78  MET A C   1 
ATOM   706  O O   . MET B 2 80  ? 40.76188 -8.46288  5.75698   1.000 12.51594  ? 78  MET A O   1 
ATOM   707  C CB  . MET B 2 80  ? 40.93267 -11.38868 6.42271   1.000 16.33594  ? 78  MET A CB  1 
ATOM   708  C CG  . MET B 2 80  ? 40.89990 -12.90734 6.25385   1.000 17.38594  ? 78  MET A CG  1 
ATOM   709  S SD  . MET B 2 80  ? 41.32260 -13.85112 7.69199   1.000 28.24594  ? 78  MET A SD  1 
ATOM   710  C CE  . MET B 2 80  ? 42.54991 -12.79998 8.49553   1.000 30.35594  ? 78  MET A CE  1 
ATOM   711  N N   . LYS B 2 81  ? 38.93448 -9.12171  4.60935   1.000 11.14260  ? 79  LYS A N   1 
ATOM   712  C CA  . LYS B 2 81  ? 38.30499 -7.80519  4.52743   1.000 13.43260  ? 79  LYS A CA  1 
ATOM   713  C C   . LYS B 2 81  ? 36.85333 -7.97408  4.95895   1.000 11.01260  ? 79  LYS A C   1 
ATOM   714  O O   . LYS B 2 81  ? 35.95969 -8.17530  4.13262   1.000 9.99260   ? 79  LYS A O   1 
ATOM   715  C CB  . LYS B 2 81  ? 38.44017 -7.23442  3.10987   1.000 17.33260  ? 79  LYS A CB  1 
ATOM   716  C CG  . LYS B 2 81  ? 39.90111 -6.98242  2.73282   1.000 21.32260  ? 79  LYS A CG  1 
ATOM   717  C CD  . LYS B 2 81  ? 40.10361 -6.64160  1.26482   1.000 26.80260  ? 79  LYS A CD  1 
ATOM   718  C CE  . LYS B 2 81  ? 41.59481 -6.36717  1.01899   1.000 31.71260  ? 79  LYS A CE  1 
ATOM   719  N NZ  . LYS B 2 81  ? 41.88520 -5.74866  -0.31034  1.000 40.52260  ? 79  LYS A NZ  1 
ATOM   720  N N   . HIS B 2 82  ? 36.63053 -7.91696  6.26992   1.000 11.79389  ? 80  HIS A N   1 
ATOM   721  C CA  . HIS B 2 82  ? 35.34329 -8.25332  6.86471   1.000 11.33389  ? 80  HIS A CA  1 
ATOM   722  C C   . HIS B 2 82  ? 35.23165 -7.50995  8.18744   1.000 10.49389  ? 80  HIS A C   1 
ATOM   723  O O   . HIS B 2 82  ? 36.21088 -7.37238  8.91729   1.000 8.77389   ? 80  HIS A O   1 
ATOM   724  C CB  . HIS B 2 82  ? 35.19386 -9.76511  7.09935   1.000 10.96389  ? 80  HIS A CB  1 
ATOM   725  C CG  . HIS B 2 82  ? 33.80152 -10.18500 7.46397   1.000 10.11389  ? 80  HIS A CG  1 
ATOM   726  N ND1 . HIS B 2 82  ? 33.30729 -10.10659 8.75372   1.000 10.89389  ? 80  HIS A ND1 1 
ATOM   727  C CD2 . HIS B 2 82  ? 32.78294 -10.64765 6.69701   1.000 9.50389   ? 80  HIS A CD2 1 
ATOM   728  C CE1 . HIS B 2 82  ? 32.04833 -10.51646 8.76244   1.000 10.43389  ? 80  HIS A CE1 1 
ATOM   729  N NE2 . HIS B 2 82  ? 31.71087 -10.86462 7.53027   1.000 9.39389   ? 80  HIS A NE2 1 
ATOM   730  N N   . GLU B 2 83  ? 34.02689 -7.03315  8.47631   1.000 10.38584  ? 81  GLU A N   1 
ATOM   731  C CA  . GLU B 2 83  ? 33.78037 -6.20991  9.65588   1.000 12.93584  ? 81  GLU A CA  1 
ATOM   732  C C   . GLU B 2 83  ? 34.04744 -6.96046  10.96999  1.000 10.24584  ? 81  GLU A C   1 
ATOM   733  O O   . GLU B 2 83  ? 34.41560 -6.34536  11.98092  1.000 9.16584   ? 81  GLU A O   1 
ATOM   734  C CB  . GLU B 2 83  ? 32.34175 -5.70538  9.54950   1.000 21.21584  ? 81  GLU A CB  1 
ATOM   735  C CG  . GLU B 2 83  ? 31.77049 -4.97333  10.71074  1.000 33.10584  ? 81  GLU A CG  1 
ATOM   736  C CD  . GLU B 2 83  ? 30.34366 -4.52589  10.42563  1.000 46.83584  ? 81  GLU A CD  1 
ATOM   737  O OE1 . GLU B 2 83  ? 29.67239 -5.16166  9.56665   1.000 41.50584  ? 81  GLU A OE1 1 
ATOM   738  O OE2 . GLU B 2 83  ? 29.89943 -3.53233  11.04756  1.000 62.90584  ? 81  GLU A OE2 1 
ATOM   739  N N   . ASN B 2 84  ? 33.91774 -8.28298  10.97781  1.000 9.73944   ? 82  ASN A N   1 
ATOM   740  C CA  . ASN B 2 84  ? 34.07627 -9.05615  12.20757  1.000 8.76944   ? 82  ASN A CA  1 
ATOM   741  C C   . ASN B 2 84  ? 35.40206 -9.81173  12.25053  1.000 8.51944   ? 82  ASN A C   1 
ATOM   742  O O   . ASN B 2 84  ? 35.54921 -10.76409 13.02891  1.000 8.19944   ? 82  ASN A O   1 
ATOM   743  C CB  . ASN B 2 84  ? 32.90108 -10.02534 12.36951  1.000 8.14944   ? 82  ASN A CB  1 
ATOM   744  C CG  . ASN B 2 84  ? 31.57690 -9.30812  12.45889  1.000 9.60944   ? 82  ASN A CG  1 
ATOM   745  O OD1 . ASN B 2 84  ? 30.68090 -9.53507  11.64980  1.000 8.59944   ? 82  ASN A OD1 1 
ATOM   746  N ND2 . ASN B 2 84  ? 31.44816 -8.42065  13.44636  1.000 10.40944  ? 82  ASN A ND2 1 
ATOM   747  N N   . VAL B 2 85  ? 36.36573 -9.42734  11.40955  1.000 7.78587   ? 83  VAL A N   1 
ATOM   748  C CA  . VAL B 2 85  ? 37.64521 -10.12246 11.28789  1.000 9.07587   ? 83  VAL A CA  1 
ATOM   749  C C   . VAL B 2 85  ? 38.74160 -9.06419  11.27929  1.000 10.81587  ? 83  VAL A C   1 
ATOM   750  O O   . VAL B 2 85  ? 38.54204 -7.97658  10.72493  1.000 10.34587  ? 83  VAL A O   1 
ATOM   751  C CB  . VAL B 2 85  ? 37.71268 -10.98710 10.00369  1.000 9.41587   ? 83  VAL A CB  1 
ATOM   752  C CG1 . VAL B 2 85  ? 39.05959 -11.68758 9.88047   1.000 10.57587  ? 83  VAL A CG1 1 
ATOM   753  C CG2 . VAL B 2 85  ? 36.56738 -12.02475 9.95170   1.000 10.16587  ? 83  VAL A CG2 1 
ATOM   754  N N   . ILE B 2 86  ? 39.86696 -9.36718  11.94632  1.000 11.04814  ? 84  ILE A N   1 
ATOM   755  C CA  . ILE B 2 86  ? 41.07313 -8.54283  11.90875  1.000 17.30814  ? 84  ILE A CA  1 
ATOM   756  C C   . ILE B 2 86  ? 41.44099 -8.25864  10.46401  1.000 14.44814  ? 84  ILE A C   1 
ATOM   757  O O   . ILE B 2 86  ? 41.37651 -9.14618  9.60681   1.000 15.24814  ? 84  ILE A O   1 
ATOM   758  C CB  . ILE B 2 86  ? 42.22604 -9.24440  12.66204  1.000 19.81814  ? 84  ILE A CB  1 
ATOM   759  C CG1 . ILE B 2 86  ? 43.48674 -8.37918  12.67708  1.000 22.45814  ? 84  ILE A CG1 1 
ATOM   760  C CG2 . ILE B 2 86  ? 42.54101 -10.64187 12.06960  1.000 20.17814  ? 84  ILE A CG2 1 
ATOM   761  C CD1 . ILE B 2 86  ? 44.76158 -9.14121  13.10260  1.000 25.22814  ? 84  ILE A CD1 1 
ATOM   762  N N   . GLY B 2 87  ? 41.72827 -6.99682  10.17231  1.000 18.62934  ? 85  GLY A N   1 
ATOM   763  C CA  . GLY B 2 87  ? 42.19132 -6.60998  8.85051   1.000 20.30934  ? 85  GLY A CA  1 
ATOM   764  C C   . GLY B 2 87  ? 43.54998 -5.93983  8.92022   1.000 17.54934  ? 85  GLY A C   1 
ATOM   765  O O   . GLY B 2 87  ? 43.95327 -5.45006  9.98155   1.000 16.72934  ? 85  GLY A O   1 
ATOM   766  N N   . LEU B 2 88  ? 44.28402 -5.92453  7.81347   1.000 15.32058  ? 86  LEU A N   1 
ATOM   767  C CA  . LEU B 2 88  ? 45.60439 -5.30662  7.80210   1.000 14.33058  ? 86  LEU A CA  1 
ATOM   768  C C   . LEU B 2 88  ? 45.41343 -3.82539  7.49314   1.000 12.40058  ? 86  LEU A C   1 
ATOM   769  O O   . LEU B 2 88  ? 45.01963 -3.46690  6.38340   1.000 15.75058  ? 86  LEU A O   1 
ATOM   770  C CB  . LEU B 2 88  ? 46.49998 -5.99364  6.77800   1.000 14.03058  ? 86  LEU A CB  1 
ATOM   771  C CG  . LEU B 2 88  ? 47.99222 -5.67307  6.76954   1.000 14.17058  ? 86  LEU A CG  1 
ATOM   772  C CD1 . LEU B 2 88  ? 48.61459 -5.96867  8.12029   1.000 16.05058  ? 86  LEU A CD1 1 
ATOM   773  C CD2 . LEU B 2 88  ? 48.63919 -6.50063  5.69305   1.000 15.10058  ? 86  LEU A CD2 1 
ATOM   774  N N   . LEU B 2 89  ? 45.65044 -2.97163  8.48144   1.000 12.91946  ? 87  LEU A N   1 
ATOM   775  C CA  . LEU B 2 89  ? 45.54906 -1.53671  8.23860   1.000 14.80946  ? 87  LEU A CA  1 
ATOM   776  C C   . LEU B 2 89  ? 46.74301 -1.01441  7.45709   1.000 12.44946  ? 87  LEU A C   1 
ATOM   777  O O   . LEU B 2 89  ? 46.60402 -0.07875  6.66520   1.000 14.38946  ? 87  LEU A O   1 
ATOM   778  C CB  . LEU B 2 89  ? 45.43370 -0.79011  9.56921   1.000 17.40946  ? 87  LEU A CB  1 
ATOM   779  C CG  . LEU B 2 89  ? 44.18915 -1.20409  10.36870  1.000 24.52946  ? 87  LEU A CG  1 
ATOM   780  C CD1 . LEU B 2 89  ? 44.15643 -0.49989  11.71330  1.000 29.62946  ? 87  LEU A CD1 1 
ATOM   781  C CD2 . LEU B 2 89  ? 42.93332 -0.91552  9.57634   1.000 22.65946  ? 87  LEU A CD2 1 
ATOM   782  N N   . ASP B 2 90  ? 47.91300 -1.60004  7.67014   1.000 12.32567  ? 88  ASP A N   1 
ATOM   783  C CA  . ASP B 2 90  ? 49.14871 -1.14496  7.06300   1.000 11.71567  ? 88  ASP A CA  1 
ATOM   784  C C   . ASP B 2 90  ? 50.17228 -2.24078  7.25349   1.000 11.32567  ? 88  ASP A C   1 
ATOM   785  O O   . ASP B 2 90  ? 50.15482 -2.95630  8.25396   1.000 11.60567  ? 88  ASP A O   1 
ATOM   786  C CB  . ASP B 2 90  ? 49.64419 0.15335   7.71088   1.000 12.49567  ? 88  ASP A CB  1 
ATOM   787  C CG  . ASP B 2 90  ? 50.71468 0.88883   6.88291   1.000 17.41567  ? 88  ASP A CG  1 
ATOM   788  O OD1 . ASP B 2 90  ? 50.88459 0.57550   5.68161   1.000 20.60567  ? 88  ASP A OD1 1 
ATOM   789  O OD2 . ASP B 2 90  ? 51.37497 1.80773   7.44258   1.000 16.26567  ? 88  ASP A OD2 1 
ATOM   790  N N   . VAL B 2 91  ? 51.07236 -2.34620  6.29570   1.000 11.74706  ? 89  VAL A N   1 
ATOM   791  C CA  . VAL B 2 91  ? 52.29394 -3.12145  6.44388   1.000 11.30706  ? 89  VAL A CA  1 
ATOM   792  C C   . VAL B 2 91  ? 53.41266 -2.27554  5.84881   1.000 11.79706  ? 89  VAL A C   1 
ATOM   793  O O   . VAL B 2 91  ? 53.22946 -1.65773  4.79613   1.000 11.76706  ? 89  VAL A O   1 
ATOM   794  C CB  . VAL B 2 91  ? 52.16907 -4.50611  5.76448   1.000 11.52706  ? 89  VAL A CB  1 
ATOM   795  C CG1 . VAL B 2 91  ? 51.70410 -4.37738  4.30069   1.000 12.18706  ? 89  VAL A CG1 1 
ATOM   796  C CG2 . VAL B 2 91  ? 53.46914 -5.29431  5.86521   1.000 12.19706  ? 89  VAL A CG2 1 
ATOM   797  N N   . PHE B 2 92  ? 54.54586 -2.19992  6.54279   1.000 11.61211  ? 90  PHE A N   1 
ATOM   798  C CA  . PHE B 2 92  ? 55.64909 -1.38599  6.05172   1.000 14.14211  ? 90  PHE A CA  1 
ATOM   799  C C   . PHE B 2 92  ? 56.97443 -1.99788  6.47374   1.000 13.77211  ? 90  PHE A C   1 
ATOM   800  O O   . PHE B 2 92  ? 57.05165 -2.80242  7.40993   1.000 13.21211  ? 90  PHE A O   1 
ATOM   801  C CB  . PHE B 2 92  ? 55.56809 0.08128   6.54273   1.000 13.34211  ? 90  PHE A CB  1 
ATOM   802  C CG  . PHE B 2 92  ? 55.60243 0.23992   8.05389   1.000 11.89211  ? 90  PHE A CG  1 
ATOM   803  C CD1 . PHE B 2 92  ? 56.81227 0.29326   8.74499   1.000 11.66211  ? 90  PHE A CD1 1 
ATOM   804  C CD2 . PHE B 2 92  ? 54.42008 0.36558   8.77282   1.000 12.97211  ? 90  PHE A CD2 1 
ATOM   805  C CE1 . PHE B 2 92  ? 56.84867 0.43539   10.10932  1.000 12.69211  ? 90  PHE A CE1 1 
ATOM   806  C CE2 . PHE B 2 92  ? 54.44560 0.51711   10.14201  1.000 12.35211  ? 90  PHE A CE2 1 
ATOM   807  C CZ  . PHE B 2 92  ? 55.65422 0.55636   10.81811  1.000 12.20211  ? 90  PHE A CZ  1 
ATOM   808  N N   . THR B 2 93  ? 58.02076 -1.56604  5.77792   1.000 12.96025  ? 91  THR A N   1 
ATOM   809  C CA  . THR B 2 93  ? 59.40597 -1.80481  6.12065   1.000 15.71025  ? 91  THR A CA  1 
ATOM   810  C C   . THR B 2 93  ? 60.16413 -0.50248  5.92220   1.000 13.74025  ? 91  THR A C   1 
ATOM   811  O O   . THR B 2 93  ? 59.80823 0.29629   5.05013   1.000 14.37025  ? 91  THR A O   1 
ATOM   812  C CB  . THR B 2 93  ? 60.03859 -2.92397  5.26383   1.000 16.75025  ? 91  THR A CB  1 
ATOM   813  O OG1 . THR B 2 93  ? 61.42682 -3.06887  5.60684   1.000 16.15025  ? 91  THR A OG1 1 
ATOM   814  C CG2 . THR B 2 93  ? 59.88428 -2.66613  3.77364   1.000 16.47025  ? 91  THR A CG2 1 
ATOM   815  N N   . PRO B 2 94  ? 61.18339 -0.23804  6.73890   1.000 15.31555  ? 92  PRO A N   1 
ATOM   816  C CA  . PRO B 2 94  ? 62.04372 0.93212   6.46417   1.000 20.07555  ? 92  PRO A CA  1 
ATOM   817  C C   . PRO B 2 94  ? 62.93816 0.75228   5.23700   1.000 20.76555  ? 92  PRO A C   1 
ATOM   818  O O   . PRO B 2 94  ? 63.46710 1.75106   4.71969   1.000 20.73555  ? 92  PRO A O   1 
ATOM   819  C CB  . PRO B 2 94  ? 62.86986 1.07283   7.74800   1.000 20.12555  ? 92  PRO A CB  1 
ATOM   820  C CG  . PRO B 2 94  ? 62.77852 -0.26918  8.42769   1.000 21.37555  ? 92  PRO A CG  1 
ATOM   821  C CD  . PRO B 2 94  ? 61.46692 -0.86094  8.04303   1.000 18.56555  ? 92  PRO A CD  1 
ATOM   822  N N   . ALA B 2 95  ? 63.07855 -0.48047  4.74916   1.000 18.00174  ? 93  ALA A N   1 
ATOM   823  C CA  . ALA B 2 95  ? 63.94967 -0.79786  3.62449   1.000 20.84174  ? 93  ALA A CA  1 
ATOM   824  C C   . ALA B 2 95  ? 63.49815 -0.12746  2.33960   1.000 21.16174  ? 93  ALA A C   1 
ATOM   825  O O   . ALA B 2 95  ? 62.30982 -0.11692  2.00006   1.000 18.55174  ? 93  ALA A O   1 
ATOM   826  C CB  . ALA B 2 95  ? 63.97776 -2.30681  3.40611   1.000 19.51174  ? 93  ALA A CB  1 
ATOM   827  N N   . ARG B 2 96  ? 64.46571 0.39811   1.59647   1.000 22.58939  ? 94  ARG A N   1 
ATOM   828  C CA  . ARG B 2 96  ? 64.17726 0.94939   0.28555   1.000 24.36939  ? 94  ARG A CA  1 
ATOM   829  C C   . ARG B 2 96  ? 64.38400 -0.05891  -0.83478  1.000 21.24939  ? 94  ARG A C   1 
ATOM   830  O O   . ARG B 2 96  ? 64.04582 0.24084   -1.98508  1.000 26.47939  ? 94  ARG A O   1 
ATOM   831  C CB  . ARG B 2 96  ? 65.04079 2.19050   0.04256   1.000 31.17939  ? 94  ARG A CB  1 
ATOM   832  C CG  . ARG B 2 96  ? 64.90194 3.26096   1.11161   1.000 38.30939  ? 94  ARG A CG  1 
ATOM   833  C CD  . ARG B 2 96  ? 65.81371 4.43550   0.79864   1.000 42.88939  ? 94  ARG A CD  1 
ATOM   834  N NE  . ARG B 2 96  ? 65.88421 5.41065   1.88185   1.000 48.41939  ? 94  ARG A NE  1 
ATOM   835  C CZ  . ARG B 2 96  ? 65.19425 6.54435   1.91715   1.000 46.58939  ? 94  ARG A CZ  1 
ATOM   836  N NH1 . ARG B 2 96  ? 64.34665 6.86877   0.95188   1.000 41.95939  ? 94  ARG A NH1 1 
ATOM   837  N NH2 . ARG B 2 96  ? 65.36084 7.37385   2.94544   1.000 48.78939  ? 94  ARG A NH2 1 
ATOM   838  N N   . SER B 2 97  ? 64.90862 -1.24580  -0.53076  1.000 25.30248  ? 95  SER A N   1 
ATOM   839  C CA  . SER B 2 97  ? 65.13648 -2.26367  -1.54777  1.000 25.67248  ? 95  SER A CA  1 
ATOM   840  C C   . SER B 2 97  ? 65.08364 -3.64088  -0.90192  1.000 23.22248  ? 95  SER A C   1 
ATOM   841  O O   . SER B 2 97  ? 65.15828 -3.77814  0.32151   1.000 25.03248  ? 95  SER A O   1 
ATOM   842  C CB  . SER B 2 97  ? 66.48933 -2.07086  -2.23951  1.000 28.79248  ? 95  SER A CB  1 
ATOM   843  O OG  . SER B 2 97  ? 67.53882 -2.49230  -1.38526  1.000 29.89248  ? 95  SER A OG  1 
ATOM   844  N N   . LEU B 2 98  ? 64.98922 -4.67244  -1.75206  1.000 22.03310  ? 96  LEU A N   1 
ATOM   845  C CA  . LEU B 2 98  ? 65.00137 -6.05020  -1.26600  1.000 21.30310  ? 96  LEU A CA  1 
ATOM   846  C C   . LEU B 2 98  ? 66.31675 -6.40096  -0.57992  1.000 25.37310  ? 96  LEU A C   1 
ATOM   847  O O   . LEU B 2 98  ? 66.33082 -7.17931  0.38475   1.000 20.90310  ? 96  LEU A O   1 
ATOM   848  C CB  . LEU B 2 98  ? 64.72783 -7.00516  -2.43042  1.000 23.74310  ? 96  LEU A CB  1 
ATOM   849  C CG  . LEU B 2 98  ? 64.85645 -8.50683  -2.17541  1.000 23.27310  ? 96  LEU A CG  1 
ATOM   850  C CD1 . LEU B 2 98  ? 63.85399 -8.97927  -1.12198  1.000 21.81310  ? 96  LEU A CD1 1 
ATOM   851  C CD2 . LEU B 2 98  ? 64.69512 -9.28505  -3.47952  1.000 24.69310  ? 96  LEU A CD2 1 
ATOM   852  N N   . GLU B 2 99  ? 67.42847 -5.82165  -1.04048  1.000 23.98494  ? 97  GLU A N   1 
ATOM   853  C CA  . GLU B 2 99  ? 68.72558 -6.14500  -0.45284  1.000 27.62494  ? 97  GLU A CA  1 
ATOM   854  C C   . GLU B 2 99  ? 68.83088 -5.68625  0.99710   1.000 24.45494  ? 97  GLU A C   1 
ATOM   855  O O   . GLU B 2 99  ? 69.47391 -6.35874  1.80689   1.000 26.21494  ? 97  GLU A O   1 
ATOM   856  C CB  . GLU B 2 99  ? 69.84992 -5.52877  -1.28624  1.000 38.09494  ? 97  GLU A CB  1 
ATOM   857  C CG  . GLU B 2 99  ? 69.74605 -5.81763  -2.77553  1.000 48.82494  ? 97  GLU A CG  1 
ATOM   858  C CD  . GLU B 2 99  ? 68.92956 -4.76815  -3.52292  1.000 61.44494  ? 97  GLU A CD  1 
ATOM   859  O OE1 . GLU B 2 99  ? 69.41760 -3.62420  -3.68108  1.000 75.71494  ? 97  GLU A OE1 1 
ATOM   860  O OE2 . GLU B 2 99  ? 67.78981 -5.08653  -3.93137  1.000 48.97494  ? 97  GLU A OE2 1 
ATOM   861  N N   . GLU B 2 100 ? 68.19359 -4.57692  1.36741   1.000 25.04450  ? 98  GLU A N   1 
ATOM   862  C CA  . GLU B 2 100 ? 68.20769 -4.17489  2.77002   1.000 29.74450  ? 98  GLU A CA  1 
ATOM   863  C C   . GLU B 2 100 ? 66.93205 -4.55568  3.51951   1.000 26.31450  ? 98  GLU A C   1 
ATOM   864  O O   . GLU B 2 100 ? 66.77245 -4.16914  4.68123   1.000 29.07450  ? 98  GLU A O   1 
ATOM   865  C CB  . GLU B 2 100 ? 68.49001 -2.67427  2.90595   1.000 36.60450  ? 98  GLU A CB  1 
ATOM   866  C CG  . GLU B 2 100 ? 67.50569 -1.72418  2.25751   1.000 43.92450  ? 98  GLU A CG  1 
ATOM   867  C CD  . GLU B 2 100 ? 67.70335 -0.28633  2.74500   1.000 48.22450  ? 98  GLU A CD  1 
ATOM   868  O OE1 . GLU B 2 100 ? 68.49689 -0.08520  3.69167   1.000 55.12450  ? 98  GLU A OE1 1 
ATOM   869  O OE2 . GLU B 2 100 ? 67.06791 0.63870   2.18999   1.000 46.53450  ? 98  GLU A OE2 1 
ATOM   870  N N   . PHE B 2 101 ? 66.05123 -5.33883  2.90161   1.000 29.48873  ? 99  PHE A N   1 
ATOM   871  C CA  . PHE B 2 101 ? 64.81878 -5.79817  3.53693   1.000 24.43873  ? 99  PHE A CA  1 
ATOM   872  C C   . PHE B 2 101 ? 65.14460 -6.78041  4.64990   1.000 25.44873  ? 99  PHE A C   1 
ATOM   873  O O   . PHE B 2 101 ? 65.64531 -7.87707  4.39515   1.000 26.34873  ? 99  PHE A O   1 
ATOM   874  C CB  . PHE B 2 101 ? 63.92662 -6.43438  2.48000   1.000 20.37873  ? 99  PHE A CB  1 
ATOM   875  C CG  . PHE B 2 101 ? 62.58744 -6.88244  2.97860   1.000 17.50873  ? 99  PHE A CG  1 
ATOM   876  C CD1 . PHE B 2 101 ? 61.79072 -6.04474  3.74895   1.000 18.43873  ? 99  PHE A CD1 1 
ATOM   877  C CD2 . PHE B 2 101 ? 62.09677 -8.13166  2.60875   1.000 15.12873  ? 99  PHE A CD2 1 
ATOM   878  C CE1 . PHE B 2 101 ? 60.53333 -6.46123  4.16031   1.000 17.48873  ? 99  PHE A CE1 1 
ATOM   879  C CE2 . PHE B 2 101 ? 60.85177 -8.55473  3.01438   1.000 15.79873  ? 99  PHE A CE2 1 
ATOM   880  C CZ  . PHE B 2 101 ? 60.06855 -7.72187  3.79733   1.000 17.08873  ? 99  PHE A CZ  1 
ATOM   881  N N   . ASN B 2 102 ? 64.86322 -6.39403  5.88509   1.000 21.81013  ? 100 ASN A N   1 
ATOM   882  C CA  . ASN B 2 102 ? 65.15083 -7.26013  7.01765   1.000 25.22013  ? 100 ASN A CA  1 
ATOM   883  C C   . ASN B 2 102 ? 63.98323 -7.30470  7.98939   1.000 25.08013  ? 100 ASN A C   1 
ATOM   884  O O   . ASN B 2 102 ? 63.77212 -8.31544  8.66742   1.000 26.33013  ? 100 ASN A O   1 
ATOM   885  C CB  . ASN B 2 102 ? 66.40720 -6.79175  7.75282   1.000 32.65013  ? 100 ASN A CB  1 
ATOM   886  C CG  . ASN B 2 102 ? 67.67703 -7.29193  7.10212   1.000 40.87013  ? 100 ASN A CG  1 
ATOM   887  O OD1 . ASN B 2 102 ? 68.34671 -6.55774  6.37198   1.000 50.87013  ? 100 ASN A OD1 1 
ATOM   888  N ND2 . ASN B 2 102 ? 68.01073 -8.55404  7.35309   1.000 48.44013  ? 100 ASN A ND2 1 
ATOM   889  N N   . ASP B 2 103 ? 63.21353 -6.22054  8.05876   1.000 24.24050  ? 101 ASP A N   1 
ATOM   890  C CA  . ASP B 2 103 ? 62.20939 -6.05384  9.09529   1.000 22.58050  ? 101 ASP A CA  1 
ATOM   891  C C   . ASP B 2 103 ? 60.83900 -5.83910  8.47789   1.000 18.62050  ? 101 ASP A C   1 
ATOM   892  O O   . ASP B 2 103 ? 60.71476 -5.19098  7.43923   1.000 16.99050  ? 101 ASP A O   1 
ATOM   893  C CB  . ASP B 2 103 ? 62.57641 -4.89208  9.98925   1.000 26.33050  ? 101 ASP A CB  1 
ATOM   894  C CG  . ASP B 2 103 ? 63.72324 -5.22823  10.91664  1.000 36.01050  ? 101 ASP A CG  1 
ATOM   895  O OD1 . ASP B 2 103 ? 63.74925 -6.35419  11.47044  1.000 41.74050  ? 101 ASP A OD1 1 
ATOM   896  O OD2 . ASP B 2 103 ? 64.60859 -4.37014  11.08384  1.000 39.77050  ? 101 ASP A OD2 1 
ATOM   897  N N   . VAL B 2 104 ? 59.82282 -6.41172  9.11788   1.000 16.95087  ? 102 VAL A N   1 
ATOM   898  C CA  . VAL B 2 104 ? 58.43530 -6.34506  8.68098   1.000 17.77087  ? 102 VAL A CA  1 
ATOM   899  C C   . VAL B 2 104 ? 57.59914 -5.86671  9.85849   1.000 14.59087  ? 102 VAL A C   1 
ATOM   900  O O   . VAL B 2 104 ? 57.69013 -6.43365  10.95270  1.000 16.35087  ? 102 VAL A O   1 
ATOM   901  C CB  . VAL B 2 104 ? 57.91314 -7.71718  8.20202   1.000 18.36087  ? 102 VAL A CB  1 
ATOM   902  C CG1 . VAL B 2 104 ? 56.43103 -7.65039  7.87747   1.000 19.82087  ? 102 VAL A CG1 1 
ATOM   903  C CG2 . VAL B 2 104 ? 58.70068 -8.20128  7.00542   1.000 21.75087  ? 102 VAL A CG2 1 
ATOM   904  N N   . TYR B 2 105 ? 56.75991 -4.86412  9.62050   1.000 13.83191  ? 103 TYR A N   1 
ATOM   905  C CA  . TYR B 2 105 ? 55.85371 -4.31649  10.61458  1.000 13.87191  ? 103 TYR A CA  1 
ATOM   906  C C   . TYR B 2 105 ? 54.42220 -4.44228  10.11138  1.000 13.56191  ? 103 TYR A C   1 
ATOM   907  O O   . TYR B 2 105 ? 54.12648 -4.06173  8.97301   1.000 11.68191  ? 103 TYR A O   1 
ATOM   908  C CB  . TYR B 2 105 ? 56.16611 -2.84791  10.87854  1.000 14.40191  ? 103 TYR A CB  1 
ATOM   909  C CG  . TYR B 2 105 ? 57.51297 -2.51986  11.50782  1.000 15.03191  ? 103 TYR A CG  1 
ATOM   910  C CD1 . TYR B 2 105 ? 58.66768 -2.41495  10.72527  1.000 17.31191  ? 103 TYR A CD1 1 
ATOM   911  C CD2 . TYR B 2 105 ? 57.62188 -2.24457  12.87189  1.000 14.85191  ? 103 TYR A CD2 1 
ATOM   912  C CE1 . TYR B 2 105 ? 59.89416 -2.07374  11.29040  1.000 17.42191  ? 103 TYR A CE1 1 
ATOM   913  C CE2 . TYR B 2 105 ? 58.85000 -1.90159  13.44548  1.000 15.68191  ? 103 TYR A CE2 1 
ATOM   914  C CZ  . TYR B 2 105 ? 59.98137 -1.82469  12.64940  1.000 16.75191  ? 103 TYR A CZ  1 
ATOM   915  O OH  . TYR B 2 105 ? 61.20414 -1.48820  13.19592  1.000 16.38191  ? 103 TYR A OH  1 
ATOM   916  N N   . LEU B 2 106 ? 53.52924 -4.94857  10.96252  1.000 14.78140  ? 104 LEU A N   1 
ATOM   917  C CA  . LEU B 2 106 ? 52.12101 -5.14494  10.62038  1.000 13.48140  ? 104 LEU A CA  1 
ATOM   918  C C   . LEU B 2 106 ? 51.26503 -4.26843  11.51773  1.000 13.96140  ? 104 LEU A C   1 
ATOM   919  O O   . LEU B 2 106 ? 51.42338 -4.29663  12.74150  1.000 15.20140  ? 104 LEU A O   1 
ATOM   920  C CB  . LEU B 2 106 ? 51.70078 -6.61191  10.80625  1.000 14.35140  ? 104 LEU A CB  1 
ATOM   921  C CG  . LEU B 2 106 ? 52.49331 -7.65297  10.01193  1.000 16.41140  ? 104 LEU A CG  1 
ATOM   922  C CD1 . LEU B 2 106 ? 52.22030 -9.05589  10.53522  1.000 19.87140  ? 104 LEU A CD1 1 
ATOM   923  C CD2 . LEU B 2 106 ? 52.13066 -7.54941  8.53732   1.000 15.67140  ? 104 LEU A CD2 1 
ATOM   924  N N   . VAL B 2 107 ? 50.33523 -3.52357  10.92598  1.000 13.58790  ? 105 VAL A N   1 
ATOM   925  C CA  . VAL B 2 107 ? 49.48012 -2.60323  11.67353  1.000 13.64790  ? 105 VAL A CA  1 
ATOM   926  C C   . VAL B 2 107 ? 48.04735 -3.11710  11.59913  1.000 13.89790  ? 105 VAL A C   1 
ATOM   927  O O   . VAL B 2 107 ? 47.51421 -3.33979  10.50422  1.000 11.04790  ? 105 VAL A O   1 
ATOM   928  C CB  . VAL B 2 107 ? 49.58151 -1.16414  11.14323  1.000 13.06790  ? 105 VAL A CB  1 
ATOM   929  C CG1 . VAL B 2 107 ? 48.68325 -0.23786  11.97327  1.000 14.21790  ? 105 VAL A CG1 1 
ATOM   930  C CG2 . VAL B 2 107 ? 51.03710 -0.69777  11.15854  1.000 12.16790  ? 105 VAL A CG2 1 
ATOM   931  N N   . THR B 2 108 ? 47.42608 -3.32357  12.76551  1.000 18.05660  ? 106 THR A N   1 
ATOM   932  C CA  . THR B 2 108 ? 46.08755 -3.91188  12.82242  1.000 23.17660  ? 106 THR A CA  1 
ATOM   933  C C   . THR B 2 108 ? 45.26259 -3.22376  13.90248  1.000 25.13660  ? 106 THR A C   1 
ATOM   934  O O   . THR B 2 108 ? 45.70786 -2.26900  14.56009  1.000 20.16660  ? 106 THR A O   1 
ATOM   935  C CB  . THR B 2 108 ? 46.11852 -5.43470  13.08182  1.000 25.40660  ? 106 THR A CB  1 
ATOM   936  O OG1 . THR B 2 108 ? 46.97543 -5.73694  14.18908  1.000 28.75660  ? 106 THR A OG1 1 
ATOM   937  C CG2 . THR B 2 108 ? 46.59178 -6.21616  11.85048  1.000 28.27660  ? 106 THR A CG2 1 
ATOM   938  N N   . HIS B 2 109 ? 44.02960 -3.71596  14.03828  1.000 28.01717  ? 107 HIS A N   1 
ATOM   939  C CA  . HIS B 2 109 ? 43.11574 -3.32870  15.11199  1.000 31.39717  ? 107 HIS A CA  1 
ATOM   940  C C   . HIS B 2 109 ? 43.75691 -3.52253  16.47973  1.000 23.21717  ? 107 HIS A C   1 
ATOM   941  O O   . HIS B 2 109 ? 44.28118 -4.59905  16.78849  1.000 27.41717  ? 107 HIS A O   1 
ATOM   942  C CB  . HIS B 2 109 ? 41.84167 -4.17525  15.00428  1.000 34.12717  ? 107 HIS A CB  1 
ATOM   943  C CG  . HIS B 2 109 ? 40.82909 -3.91366  16.07748  1.000 40.25717  ? 107 HIS A CG  1 
ATOM   944  N ND1 . HIS B 2 109 ? 39.77218 -3.04578  15.90083  1.000 41.02717  ? 107 HIS A ND1 1 
ATOM   945  C CD2 . HIS B 2 109 ? 40.68324 -4.43775  17.32097  1.000 38.04717  ? 107 HIS A CD2 1 
ATOM   946  C CE1 . HIS B 2 109 ? 39.03317 -3.02903  16.99733  1.000 43.91717  ? 107 HIS A CE1 1 
ATOM   947  N NE2 . HIS B 2 109 ? 39.56462 -3.86317  17.87450  1.000 33.61717  ? 107 HIS A NE2 1 
ATOM   948  N N   . LEU B 2 110 ? 43.71493 -2.48403  17.30726  1.000 27.12717  ? 108 LEU A N   1 
ATOM   949  C CA  . LEU B 2 110 ? 44.26018 -2.59979  18.65551  1.000 29.35717  ? 108 LEU A CA  1 
ATOM   950  C C   . LEU B 2 110 ? 43.28165 -3.36240  19.54476  1.000 28.26717  ? 108 LEU A C   1 
ATOM   951  O O   . LEU B 2 110 ? 42.12875 -2.94766  19.70353  1.000 26.73717  ? 108 LEU A O   1 
ATOM   952  C CB  . LEU B 2 110 ? 44.55062 -1.22982  19.25673  1.000 27.11717  ? 108 LEU A CB  1 
ATOM   953  C CG  . LEU B 2 110 ? 45.13098 -1.27897  20.67673  1.000 27.57717  ? 108 LEU A CG  1 
ATOM   954  C CD1 . LEU B 2 110 ? 46.32916 -2.21471  20.77494  1.000 26.35717  ? 108 LEU A CD1 1 
ATOM   955  C CD2 . LEU B 2 110 ? 45.53212 0.10738   21.11247  1.000 30.08717  ? 108 LEU A CD2 1 
ATOM   956  N N   . MET B 2 111 ? 43.74428 -4.47353  20.12470  1.000 27.76151  ? 109 MET A N   1 
ATOM   957  C CA  . MET B 2 111 ? 42.96207 -5.19946  21.12332  1.000 38.39151  ? 109 MET A CA  1 
ATOM   958  C C   . MET B 2 111 ? 42.84194 -4.33820  22.37783  1.000 31.28151  ? 109 MET A C   1 
ATOM   959  O O   . MET B 2 111 ? 43.81743 -4.15086  23.11222  1.000 34.24151  ? 109 MET A O   1 
ATOM   960  C CB  . MET B 2 111 ? 43.61602 -6.54679  21.43214  1.000 37.24151  ? 109 MET A CB  1 
ATOM   961  C CG  . MET B 2 111 ? 43.10862 -7.25598  22.68965  1.000 45.39151  ? 109 MET A CG  1 
ATOM   962  S SD  . MET B 2 111 ? 41.50449 -8.04411  22.46934  1.000 47.42151  ? 109 MET A SD  1 
ATOM   963  C CE  . MET B 2 111 ? 41.96637 -9.61106  21.71739  1.000 37.11151  ? 109 MET A CE  1 
ATOM   964  N N   . GLY B 2 112 ? 41.66741 -3.76146  22.59741  1.000 34.77129  ? 110 GLY A N   1 
ATOM   965  C CA  . GLY B 2 112 ? 41.37647 -3.20763  23.90611  1.000 40.10129  ? 110 GLY A CA  1 
ATOM   966  C C   . GLY B 2 112 ? 40.86519 -4.30574  24.82088  1.000 39.02129  ? 110 GLY A C   1 
ATOM   967  O O   . GLY B 2 112 ? 41.64784 -5.08391  25.38465  1.000 34.23129  ? 110 GLY A O   1 
ATOM   968  N N   . ALA B 2 113 ? 39.54748 -4.40943  24.95290  1.000 35.78315  ? 111 ALA A N   1 
ATOM   969  C CA  . ALA B 2 113 ? 38.95918 -5.45753  25.77158  1.000 26.68315  ? 111 ALA A CA  1 
ATOM   970  C C   . ALA B 2 113 ? 38.70631 -6.69148  24.91632  1.000 21.78315  ? 111 ALA A C   1 
ATOM   971  O O   . ALA B 2 113 ? 38.18214 -6.57974  23.80335  1.000 20.25315  ? 111 ALA A O   1 
ATOM   972  C CB  . ALA B 2 113 ? 37.65825 -4.97878  26.41267  1.000 26.12315  ? 111 ALA A CB  1 
ATOM   973  N N   . ASP B 2 114 ? 39.08700 -7.86023  25.43890  1.000 20.08783  ? 112 ASP A N   1 
ATOM   974  C CA  . ASP B 2 114 ? 38.67624 -9.12706  24.86020  1.000 18.56783  ? 112 ASP A CA  1 
ATOM   975  C C   . ASP B 2 114 ? 37.41689 -9.62625  25.56686  1.000 17.90783  ? 112 ASP A C   1 
ATOM   976  O O   . ASP B 2 114 ? 36.87637 -8.96470  26.45663  1.000 16.98783  ? 112 ASP A O   1 
ATOM   977  C CB  . ASP B 2 114 ? 39.81835 -10.15691 24.87612  1.000 19.96783  ? 112 ASP A CB  1 
ATOM   978  C CG  . ASP B 2 114 ? 40.30678 -10.56076 26.28890  1.000 25.34783  ? 112 ASP A CG  1 
ATOM   979  O OD1 . ASP B 2 114 ? 39.56515 -10.52279 27.29746  1.000 26.92783  ? 112 ASP A OD1 1 
ATOM   980  O OD2 . ASP B 2 114 ? 41.48636 -10.97376 26.38145  1.000 30.31783  ? 112 ASP A OD2 1 
ATOM   981  N N   . LEU B 2 115 ? 36.94724 -10.81577 25.17617  1.000 13.77258  ? 113 LEU A N   1 
ATOM   982  C CA  . LEU B 2 115 ? 35.69544 -11.33809 25.72464  1.000 16.04258  ? 113 LEU A CA  1 
ATOM   983  C C   . LEU B 2 115 ? 35.81409 -11.67607 27.21834  1.000 18.02258  ? 113 LEU A C   1 
ATOM   984  O O   . LEU B 2 115 ? 34.86614 -11.45705 27.97965  1.000 18.88258  ? 113 LEU A O   1 
ATOM   985  C CB  . LEU B 2 115 ? 35.25602 -12.55332 24.91180  1.000 19.71258  ? 113 LEU A CB  1 
ATOM   986  C CG  . LEU B 2 115 ? 33.83769 -13.07852 25.12482  1.000 23.19258  ? 113 LEU A CG  1 
ATOM   987  C CD1 . LEU B 2 115 ? 32.81935 -11.95522 25.05157  1.000 24.65258  ? 113 LEU A CD1 1 
ATOM   988  C CD2 . LEU B 2 115 ? 33.53484 -14.10689 24.07166  1.000 24.72258  ? 113 LEU A CD2 1 
ATOM   989  N N   . ASN B 2 116 ? 36.95826 -12.21543 27.65166  1.000 16.97604  ? 114 ASN A N   1 
ATOM   990  C CA  . ASN B 2 116 ? 37.20150 -12.43336 29.08506  1.000 19.76604  ? 114 ASN A CA  1 
ATOM   991  C C   . ASN B 2 116 ? 37.14222 -11.13085 29.86881  1.000 22.74604  ? 114 ASN A C   1 
ATOM   992  O O   . ASN B 2 116 ? 36.62910 -11.09082 30.99571  1.000 22.87604  ? 114 ASN A O   1 
ATOM   993  C CB  . ASN B 2 116 ? 38.57124 -13.06836 29.30740  1.000 22.17604  ? 114 ASN A CB  1 
ATOM   994  C CG  . ASN B 2 116 ? 38.58998 -14.53731 29.00598  1.000 26.72604  ? 114 ASN A CG  1 
ATOM   995  O OD1 . ASN B 2 116 ? 37.59352 -15.24051 29.19017  1.000 26.81604  ? 114 ASN A OD1 1 
ATOM   996  N ND2 . ASN B 2 116 ? 39.74054 -15.02348 28.55112  1.000 32.79604  ? 114 ASN A ND2 1 
ATOM   997  N N   . ASN B 2 117 ? 37.69295 -10.06156 29.29947  1.000 19.09307  ? 115 ASN A N   1 
ATOM   998  C CA  . ASN B 2 117 ? 37.72393 -8.78796  29.99844  1.000 21.34307  ? 115 ASN A CA  1 
ATOM   999  C C   . ASN B 2 117 ? 36.33132 -8.20354  30.16023  1.000 18.59307  ? 115 ASN A C   1 
ATOM   1000 O O   . ASN B 2 117 ? 36.03411 -7.61027  31.20016  1.000 16.82307  ? 115 ASN A O   1 
ATOM   1001 C CB  . ASN B 2 117 ? 38.64022 -7.80598  29.25800  1.000 26.40307  ? 115 ASN A CB  1 
ATOM   1002 C CG  . ASN B 2 117 ? 40.09870 -8.23955  29.26794  1.000 37.11307  ? 115 ASN A CG  1 
ATOM   1003 O OD1 . ASN B 2 117 ? 40.52338 -9.02260  30.12448  1.000 51.78307  ? 115 ASN A OD1 1 
ATOM   1004 N ND2 . ASN B 2 117 ? 40.87470 -7.73423  28.30701  1.000 43.82307  ? 115 ASN A ND2 1 
ATOM   1005 N N   . ILE B 2 118 ? 35.45373 -8.35878  29.16237  1.000 15.21995  ? 116 ILE A N   1 
ATOM   1006 C CA  . ILE B 2 118 ? 34.17125 -7.67588  29.28732  1.000 15.98995  ? 116 ILE A CA  1 
ATOM   1007 C C   . ILE B 2 118 ? 33.28949 -8.33822  30.35506  1.000 16.90995  ? 116 ILE A C   1 
ATOM   1008 O O   . ILE B 2 118 ? 32.45767 -7.66872  30.97510  1.000 15.38995  ? 116 ILE A O   1 
ATOM   1009 C CB  . ILE B 2 118 ? 33.44405 -7.57434  27.92963  1.000 19.79995  ? 116 ILE A CB  1 
ATOM   1010 C CG1 . ILE B 2 118 ? 32.87845 -8.91134  27.48254  1.000 25.01995  ? 116 ILE A CG1 1 
ATOM   1011 C CG2 . ILE B 2 118 ? 34.36100 -6.95514  26.85639  1.000 22.01995  ? 116 ILE A CG2 1 
ATOM   1012 C CD1 . ILE B 2 118 ? 31.76899 -8.76517  26.46314  1.000 31.49995  ? 116 ILE A CD1 1 
ATOM   1013 N N   . VAL B 2 119 ? 33.47590 -9.63134  30.63137  1.000 16.59317  ? 117 VAL A N   1 
ATOM   1014 C CA  . VAL B 2 119 ? 32.65567 -10.24922 31.67581  1.000 19.23317  ? 117 VAL A CA  1 
ATOM   1015 C C   . VAL B 2 119 ? 33.16372 -9.95208  33.07817  1.000 20.42317  ? 117 VAL A C   1 
ATOM   1016 O O   . VAL B 2 119 ? 32.41820 -10.14615 34.04925  1.000 17.05317  ? 117 VAL A O   1 
ATOM   1017 C CB  . VAL B 2 119 ? 32.51982 -11.76612 31.44602  1.000 21.04317  ? 117 VAL A CB  1 
ATOM   1018 C CG1 . VAL B 2 119 ? 32.19950 -12.04680 29.98070  1.000 23.75317  ? 117 VAL A CG1 1 
ATOM   1019 C CG2 . VAL B 2 119 ? 33.76129 -12.49885 31.86421  1.000 23.81317  ? 117 VAL A CG2 1 
ATOM   1020 N N   . LYS B 2 120 ? 34.38486 -9.42721  33.22225  1.000 16.18471  ? 118 LYS A N   1 
ATOM   1021 C CA  . LYS B 2 120 ? 34.89125 -9.12198  34.55571  1.000 20.39471  ? 118 LYS A CA  1 
ATOM   1022 C C   . LYS B 2 120 ? 34.22126 -7.91018  35.19705  1.000 20.72471  ? 118 LYS A C   1 
ATOM   1023 O O   . LYS B 2 120 ? 34.28978 -7.76487  36.42290  1.000 22.06471  ? 118 LYS A O   1 
ATOM   1024 C CB  . LYS B 2 120 ? 36.40117 -8.90520  34.51309  1.000 23.93471  ? 118 LYS A CB  1 
ATOM   1025 C CG  . LYS B 2 120 ? 37.18905 -10.18664 34.32286  1.000 32.10471  ? 118 LYS A CG  1 
ATOM   1026 C CD  . LYS B 2 120 ? 38.64824 -9.88283  34.03385  1.000 44.70471  ? 118 LYS A CD  1 
ATOM   1027 C CE  . LYS B 2 120 ? 39.38607 -9.37792  35.27054  1.000 60.08471  ? 118 LYS A CE  1 
ATOM   1028 N NZ  . LYS B 2 120 ? 39.94875 -10.49244 36.09794  1.000 64.52471  ? 118 LYS A NZ  1 
ATOM   1029 N N   . CYS B 2 121 ? 33.59960 -7.01974  34.42538  1.000 18.97831  ? 119 CYS A N   1 
ATOM   1030 C CA  . CYS B 2 121 ? 32.98665 -5.85324  35.04704  1.000 21.52831  ? 119 CYS A CA  1 
ATOM   1031 C C   . CYS B 2 121 ? 31.51345 -5.68207  34.70066  1.000 17.74831  ? 119 CYS A C   1 
ATOM   1032 O O   . CYS B 2 121 ? 30.93683 -4.63732  35.03419  1.000 18.66831  ? 119 CYS A O   1 
ATOM   1033 C CB  . CYS B 2 121 ? 33.77088 -4.58238  34.69846  1.000 31.24831  ? 119 CYS A CB  1 
ATOM   1034 S SG  . CYS B 2 121 ? 33.88662 -4.23243  32.94850  1.000 39.23831  ? 119 CYS A SG  1 
ATOM   1035 N N   . GLN B 2 122 ? 30.87367 -6.68198  34.08717  1.000 17.92517  ? 120 GLN A N   1 
ATOM   1036 C CA  . GLN B 2 122 ? 29.42417 -6.64269  33.91284  1.000 15.42517  ? 120 GLN A CA  1 
ATOM   1037 C C   . GLN B 2 122 ? 28.89153 -8.04055  33.65880  1.000 14.10517  ? 120 GLN A C   1 
ATOM   1038 O O   . GLN B 2 122 ? 29.63335 -8.96623  33.33064  1.000 16.62517  ? 120 GLN A O   1 
ATOM   1039 C CB  . GLN B 2 122 ? 28.99805 -5.73205  32.75963  1.000 18.99517  ? 120 GLN A CB  1 
ATOM   1040 C CG  . GLN B 2 122 ? 29.62089 -6.13125  31.44139  1.000 18.67517  ? 120 GLN A CG  1 
ATOM   1041 C CD  . GLN B 2 122 ? 30.20576 -4.94066  30.73391  1.000 19.62517  ? 120 GLN A CD  1 
ATOM   1042 O OE1 . GLN B 2 122 ? 29.48534 -3.99022  30.41978  1.000 18.63517  ? 120 GLN A OE1 1 
ATOM   1043 N NE2 . GLN B 2 122 ? 31.51893 -4.96079  30.51094  1.000 19.61517  ? 120 GLN A NE2 1 
ATOM   1044 N N   . LYS B 2 123 ? 27.58381 -8.17209  33.80727  1.000 13.30027  ? 121 LYS A N   1 
ATOM   1045 C CA  . LYS B 2 123 ? 26.86872 -9.39422  33.48018  1.000 16.16027  ? 121 LYS A CA  1 
ATOM   1046 C C   . LYS B 2 123 ? 26.19528 -9.19258  32.12798  1.000 16.05027  ? 121 LYS A C   1 
ATOM   1047 O O   . LYS B 2 123 ? 25.35653 -8.29568  31.97947  1.000 18.82027  ? 121 LYS A O   1 
ATOM   1048 C CB  . LYS B 2 123 ? 25.83369 -9.72111  34.55640  1.000 16.84027  ? 121 LYS A CB  1 
ATOM   1049 C CG  . LYS B 2 123 ? 24.89331 -10.88851 34.21392  1.000 17.82027  ? 121 LYS A CG  1 
ATOM   1050 C CD  . LYS B 2 123 ? 23.97706 -11.22374 35.38664  1.000 19.75027  ? 121 LYS A CD  1 
ATOM   1051 C CE  . LYS B 2 123 ? 23.27776 -12.57377 35.19157  1.000 22.87027  ? 121 LYS A CE  1 
ATOM   1052 N NZ  . LYS B 2 123 ? 22.50038 -12.58399 33.93266  1.000 28.33027  ? 121 LYS A NZ  1 
ATOM   1053 N N   . LEU B 2 124 ? 26.56596 -10.01783 31.15282  1.000 17.79884  ? 122 LEU A N   1 
ATOM   1054 C CA  . LEU B 2 124 ? 25.99301 -9.91864  29.81451  1.000 17.02884  ? 122 LEU A CA  1 
ATOM   1055 C C   . LEU B 2 124 ? 24.52777 -10.34946 29.81710  1.000 17.02884  ? 122 LEU A C   1 
ATOM   1056 O O   . LEU B 2 124 ? 24.17455 -11.37339 30.41185  1.000 20.67884  ? 122 LEU A O   1 
ATOM   1057 C CB  . LEU B 2 124 ? 26.79453 -10.79553 28.84923  1.000 18.34884  ? 122 LEU A CB  1 
ATOM   1058 C CG  . LEU B 2 124 ? 28.28030 -10.44476 28.74948  1.000 20.88884  ? 122 LEU A CG  1 
ATOM   1059 C CD1 . LEU B 2 124 ? 29.00052 -11.37714 27.77365  1.000 20.14884  ? 122 LEU A CD1 1 
ATOM   1060 C CD2 . LEU B 2 124 ? 28.45180 -8.98904  28.32497  1.000 24.87884  ? 122 LEU A CD2 1 
ATOM   1061 N N   . THR B 2 125 ? 23.67739 -9.57990  29.13665  1.000 18.03340  ? 123 THR A N   1 
ATOM   1062 C CA  . THR B 2 125 ? 22.29007 -9.96852  28.91117  1.000 19.24340  ? 123 THR A CA  1 
ATOM   1063 C C   . THR B 2 125 ? 22.22710 -11.02630 27.80911  1.000 20.39340  ? 123 THR A C   1 
ATOM   1064 O O   . THR B 2 125 ? 23.20969 -11.26762 27.10013  1.000 15.98340  ? 123 THR A O   1 
ATOM   1065 C CB  . THR B 2 125 ? 21.44425 -8.74895  28.53005  1.000 23.73340  ? 123 THR A CB  1 
ATOM   1066 O OG1 . THR B 2 125 ? 21.85744 -8.25073  27.24711  1.000 22.63340  ? 123 THR A OG1 1 
ATOM   1067 C CG2 . THR B 2 125 ? 21.62551 -7.62737  29.56289  1.000 24.31340  ? 123 THR A CG2 1 
ATOM   1068 N N   . ASP B 2 126 ? 21.05858 -11.67165 27.66032  1.000 19.38170  ? 124 ASP A N   1 
ATOM   1069 C CA  . ASP B 2 126 ? 20.91697 -12.62290 26.55528  1.000 21.04170  ? 124 ASP A CA  1 
ATOM   1070 C C   . ASP B 2 126 ? 20.97473 -11.90672 25.20941  1.000 18.48170  ? 124 ASP A C   1 
ATOM   1071 O O   . ASP B 2 126 ? 21.41516 -12.50399 24.22608  1.000 16.79170  ? 124 ASP A O   1 
ATOM   1072 C CB  . ASP B 2 126 ? 19.62866 -13.45346 26.66782  1.000 25.40170  ? 124 ASP A CB  1 
ATOM   1073 C CG  . ASP B 2 126 ? 19.51300 -14.55416 25.55524  1.000 29.57170  ? 124 ASP A CG  1 
ATOM   1074 O OD1 . ASP B 2 126 ? 20.40905 -15.42927 25.43738  1.000 30.12170  ? 124 ASP A OD1 1 
ATOM   1075 O OD2 . ASP B 2 126 ? 18.51995 -14.55204 24.78550  1.000 25.17170  ? 124 ASP A OD2 1 
ATOM   1076 N N   . ASP B 2 127 ? 20.56131 -10.63420 25.15407  1.000 18.61209  ? 125 ASP A N   1 
ATOM   1077 C CA  . ASP B 2 127 ? 20.73915 -9.84041  23.93813  1.000 21.10209  ? 125 ASP A CA  1 
ATOM   1078 C C   . ASP B 2 127 ? 22.21898 -9.66869  23.60491  1.000 18.09209  ? 125 ASP A C   1 
ATOM   1079 O O   . ASP B 2 127 ? 22.61692 -9.78724  22.44100  1.000 13.29209  ? 125 ASP A O   1 
ATOM   1080 C CB  . ASP B 2 127 ? 20.08083 -8.46744  24.08784  1.000 25.87209  ? 125 ASP A CB  1 
ATOM   1081 C CG  . ASP B 2 127 ? 18.63858 -8.55231  24.54735  1.000 39.66209  ? 125 ASP A CG  1 
ATOM   1082 O OD1 . ASP B 2 127 ? 17.80278 -9.14762  23.82810  1.000 39.59209  ? 125 ASP A OD1 1 
ATOM   1083 O OD2 . ASP B 2 127 ? 18.34366 -8.03068  25.64889  1.000 53.39209  ? 125 ASP A OD2 1 
ATOM   1084 N N   . HIS B 2 128 ? 23.04222 -9.36525  24.61997  1.000 16.32415  ? 126 HIS A N   1 
ATOM   1085 C CA  . HIS B 2 128 ? 24.48955 -9.25825  24.42848  1.000 16.02415  ? 126 HIS A CA  1 
ATOM   1086 C C   . HIS B 2 128 ? 25.07178 -10.55009 23.87898  1.000 14.11415  ? 126 HIS A C   1 
ATOM   1087 O O   . HIS B 2 128 ? 25.89909 -10.53086 22.95573  1.000 11.19415  ? 126 HIS A O   1 
ATOM   1088 C CB  . HIS B 2 128 ? 25.18007 -8.92719  25.75277  1.000 19.48415  ? 126 HIS A CB  1 
ATOM   1089 C CG  . HIS B 2 128 ? 25.00796 -7.51012  26.20438  1.000 23.93415  ? 126 HIS A CG  1 
ATOM   1090 N ND1 . HIS B 2 128 ? 24.78947 -7.17519  27.52374  1.000 28.83415  ? 126 HIS A ND1 1 
ATOM   1091 C CD2 . HIS B 2 128 ? 25.04860 -6.34160  25.52341  1.000 29.59415  ? 126 HIS A CD2 1 
ATOM   1092 C CE1 . HIS B 2 128 ? 24.68879 -5.86186  27.63328  1.000 27.38415  ? 126 HIS A CE1 1 
ATOM   1093 N NE2 . HIS B 2 128 ? 24.84559 -5.33126  26.43454  1.000 29.79415  ? 126 HIS A NE2 1 
ATOM   1094 N N   . VAL B 2 129 ? 24.67166 -11.68202 24.46178  1.000 11.82161  ? 127 VAL A N   1 
ATOM   1095 C CA  . VAL B 2 129 ? 25.20601 -12.96819 24.03734  1.000 12.19161  ? 127 VAL A CA  1 
ATOM   1096 C C   . VAL B 2 129 ? 24.77369 -13.27458 22.60668  1.000 10.44161  ? 127 VAL A C   1 
ATOM   1097 O O   . VAL B 2 129 ? 25.59156 -13.71320 21.78510  1.000 11.34161  ? 127 VAL A O   1 
ATOM   1098 C CB  . VAL B 2 129 ? 24.77727 -14.06562 25.03361  1.000 12.12161  ? 127 VAL A CB  1 
ATOM   1099 C CG1 . VAL B 2 129 ? 25.18621 -15.45956 24.53105  1.000 12.23161  ? 127 VAL A CG1 1 
ATOM   1100 C CG2 . VAL B 2 129 ? 25.40542 -13.79373 26.41211  1.000 14.03161  ? 127 VAL A CG2 1 
ATOM   1101 N N   . GLN B 2 130 ? 23.49009 -13.05151 22.28916  1.000 8.47552   ? 128 GLN A N   1 
ATOM   1102 C CA  . GLN B 2 130 ? 23.00661 -13.21806 20.91213  1.000 10.52552  ? 128 GLN A CA  1 
ATOM   1103 C C   . GLN B 2 130 ? 23.85616 -12.43604 19.92604  1.000 8.49552   ? 128 GLN A C   1 
ATOM   1104 O O   . GLN B 2 130 ? 24.27315 -12.96782 18.89637  1.000 7.29552   ? 128 GLN A O   1 
ATOM   1105 C CB  . GLN B 2 130 ? 21.56050 -12.73838 20.75994  1.000 13.03552  ? 128 GLN A CB  1 
ATOM   1106 C CG  . GLN B 2 130 ? 20.50983 -13.64538 21.29730  1.000 18.92552  ? 128 GLN A CG  1 
ATOM   1107 C CD  . GLN B 2 130 ? 19.12164 -13.02238 21.24601  1.000 24.95552  ? 128 GLN A CD  1 
ATOM   1108 O OE1 . GLN B 2 130 ? 18.82966 -12.17029 20.39386  1.000 26.69552  ? 128 GLN A OE1 1 
ATOM   1109 N NE2 . GLN B 2 130 ? 18.26338 -13.43536 22.17289  1.000 30.90552  ? 128 GLN A NE2 1 
ATOM   1110 N N   . PHE B 2 131 ? 24.12481 -11.16999 20.23640  1.000 8.89463   ? 129 PHE A N   1 
ATOM   1111 C CA  . PHE B 2 131 ? 24.82772 -10.32385 19.28033  1.000 9.15463   ? 129 PHE A CA  1 
ATOM   1112 C C   . PHE B 2 131 ? 26.29708 -10.71213 19.17680  1.000 8.91463   ? 129 PHE A C   1 
ATOM   1113 O O   . PHE B 2 131 ? 26.85810 -10.74407 18.06688  1.000 7.82463   ? 129 PHE A O   1 
ATOM   1114 C CB  . PHE B 2 131 ? 24.65473 -8.86109  19.68276  1.000 10.92463  ? 129 PHE A CB  1 
ATOM   1115 C CG  . PHE B 2 131 ? 25.24429 -7.87221  18.71114  1.000 12.26463  ? 129 PHE A CG  1 
ATOM   1116 C CD1 . PHE B 2 131 ? 24.92519 -7.91779  17.35932  1.000 14.30463  ? 129 PHE A CD1 1 
ATOM   1117 C CD2 . PHE B 2 131 ? 26.09378 -6.87409  19.16275  1.000 14.40463  ? 129 PHE A CD2 1 
ATOM   1118 C CE1 . PHE B 2 131 ? 25.45583 -6.98481  16.46015  1.000 14.26463  ? 129 PHE A CE1 1 
ATOM   1119 C CE2 . PHE B 2 131 ? 26.62652 -5.92586  18.26557  1.000 15.55463  ? 129 PHE A CE2 1 
ATOM   1120 C CZ  . PHE B 2 131 ? 26.30618 -5.99530  16.91418  1.000 13.91463  ? 129 PHE A CZ  1 
ATOM   1121 N N   . LEU B 2 132 ? 26.93180 -11.04366 20.31393  1.000 7.62027   ? 130 LEU A N   1 
ATOM   1122 C CA  . LEU B 2 132 ? 28.33252 -11.45685 20.27623  1.000 8.07027   ? 130 LEU A CA  1 
ATOM   1123 C C   . LEU B 2 132 ? 28.50792 -12.74821 19.49360  1.000 7.28027   ? 130 LEU A C   1 
ATOM   1124 O O   . LEU B 2 132 ? 29.40630 -12.84294 18.64710  1.000 6.61027   ? 130 LEU A O   1 
ATOM   1125 C CB  . LEU B 2 132 ? 28.90607 -11.61917 21.68910  1.000 8.61027   ? 130 LEU A CB  1 
ATOM   1126 C CG  . LEU B 2 132 ? 29.06807 -10.33732 22.49753  1.000 9.33027   ? 130 LEU A CG  1 
ATOM   1127 C CD1 . LEU B 2 132 ? 29.23920 -10.69226 23.98192  1.000 9.94027   ? 130 LEU A CD1 1 
ATOM   1128 C CD2 . LEU B 2 132 ? 30.23453 -9.47766  21.97146  1.000 10.56027  ? 130 LEU A CD2 1 
ATOM   1129 N N   . ILE B 2 133 ? 27.66098 -13.75409 19.75212  1.000 5.27387   ? 131 ILE A N   1 
ATOM   1130 C CA  . ILE B 2 133 ? 27.82242 -15.02002 19.04111  1.000 5.92387   ? 131 ILE A CA  1 
ATOM   1131 C C   . ILE B 2 133 ? 27.47401 -14.84311 17.56131  1.000 6.05387   ? 131 ILE A C   1 
ATOM   1132 O O   . ILE B 2 133 ? 28.12486 -15.43004 16.68675  1.000 6.05387   ? 131 ILE A O   1 
ATOM   1133 C CB  . ILE B 2 133 ? 26.99095 -16.14996 19.69148  1.000 5.59387   ? 131 ILE A CB  1 
ATOM   1134 C CG1 . ILE B 2 133 ? 27.42848 -16.41891 21.14744  1.000 6.14387   ? 131 ILE A CG1 1 
ATOM   1135 C CG2 . ILE B 2 133 ? 27.12037 -17.43642 18.88973  1.000 6.15387   ? 131 ILE A CG2 1 
ATOM   1136 C CD1 . ILE B 2 133 ? 28.94973 -16.66540 21.35136  1.000 6.89387   ? 131 ILE A CD1 1 
ATOM   1137 N N   . TYR B 2 134 ? 26.46186 -14.01753 17.26050  1.000 6.63549   ? 132 TYR A N   1 
ATOM   1138 C CA  . TYR B 2 134 ? 26.09826 -13.74198 15.86860  1.000 7.23549   ? 132 TYR A CA  1 
ATOM   1139 C C   . TYR B 2 134 ? 27.29019 -13.18749 15.08893  1.000 6.73549   ? 132 TYR A C   1 
ATOM   1140 O O   . TYR B 2 134 ? 27.58199 -13.63469 13.97332  1.000 5.70549   ? 132 TYR A O   1 
ATOM   1141 C CB  . TYR B 2 134 ? 24.93446 -12.74382 15.81513  1.000 8.73549   ? 132 TYR A CB  1 
ATOM   1142 C CG  . TYR B 2 134 ? 24.63164 -12.27595 14.40166  1.000 9.25549   ? 132 TYR A CG  1 
ATOM   1143 C CD1 . TYR B 2 134 ? 23.96779 -13.10363 13.51098  1.000 10.72549  ? 132 TYR A CD1 1 
ATOM   1144 C CD2 . TYR B 2 134 ? 25.03932 -11.01205 13.95833  1.000 11.47549  ? 132 TYR A CD2 1 
ATOM   1145 C CE1 . TYR B 2 134 ? 23.72133 -12.69519 12.19403  1.000 11.28549  ? 132 TYR A CE1 1 
ATOM   1146 C CE2 . TYR B 2 134 ? 24.79192 -10.59301 12.65484  1.000 12.04549  ? 132 TYR A CE2 1 
ATOM   1147 C CZ  . TYR B 2 134 ? 24.13285 -11.43494 11.78217  1.000 13.13549  ? 132 TYR A CZ  1 
ATOM   1148 O OH  . TYR B 2 134 ? 23.88216 -11.01891 10.48747  1.000 15.46549  ? 132 TYR A OH  1 
ATOM   1149 N N   . GLN B 2 135 ? 28.00835 -12.23937 15.68905  1.000 6.16402   ? 133 GLN A N   1 
ATOM   1150 C CA  . GLN B 2 135 ? 29.16067 -11.65218 15.02109  1.000 6.71402   ? 133 GLN A CA  1 
ATOM   1151 C C   . GLN B 2 135 ? 30.28472 -12.65768 14.84217  1.000 6.28402   ? 133 GLN A C   1 
ATOM   1152 O O   . GLN B 2 135 ? 30.97364 -12.62944 13.81614  1.000 6.88402   ? 133 GLN A O   1 
ATOM   1153 C CB  . GLN B 2 135 ? 29.65346 -10.44285 15.79619  1.000 6.56402   ? 133 GLN A CB  1 
ATOM   1154 C CG  . GLN B 2 135 ? 28.68849 -9.28972  15.74732  1.000 7.96402   ? 133 GLN A CG  1 
ATOM   1155 C CD  . GLN B 2 135 ? 29.17995 -8.16482  16.62373  1.000 8.73402   ? 133 GLN A CD  1 
ATOM   1156 O OE1 . GLN B 2 135 ? 29.91585 -7.29680  16.16894  1.000 10.66402  ? 133 GLN A OE1 1 
ATOM   1157 N NE2 . GLN B 2 135 ? 28.82326 -8.20496  17.89973  1.000 8.79402   ? 133 GLN A NE2 1 
ATOM   1158 N N   . ILE B 2 136 ? 30.52382 -13.51914 15.83660  1.000 5.26691   ? 134 ILE A N   1 
ATOM   1159 C CA  . ILE B 2 136 ? 31.54533 -14.55090 15.66287  1.000 5.53691   ? 134 ILE A CA  1 
ATOM   1160 C C   . ILE B 2 136 ? 31.20673 -15.43560 14.47456  1.000 5.40691   ? 134 ILE A C   1 
ATOM   1161 O O   . ILE B 2 136 ? 32.06729 -15.72238 13.63078  1.000 4.92691   ? 134 ILE A O   1 
ATOM   1162 C CB  . ILE B 2 136 ? 31.71634 -15.39800 16.93133  1.000 5.54691   ? 134 ILE A CB  1 
ATOM   1163 C CG1 . ILE B 2 136 ? 32.20809 -14.55729 18.10400  1.000 5.86691   ? 134 ILE A CG1 1 
ATOM   1164 C CG2 . ILE B 2 136 ? 32.70999 -16.53218 16.65427  1.000 6.01691   ? 134 ILE A CG2 1 
ATOM   1165 C CD1 . ILE B 2 136 ? 32.09745 -15.28982 19.44164  1.000 6.50691   ? 134 ILE A CD1 1 
ATOM   1166 N N   . LEU B 2 137 ? 29.93929 -15.86642 14.38150  1.000 5.28445   ? 135 LEU A N   1 
ATOM   1167 C CA  . LEU B 2 137 ? 29.54240 -16.75586 13.28996  1.000 5.92445   ? 135 LEU A CA  1 
ATOM   1168 C C   . LEU B 2 137 ? 29.55078 -16.03961 11.94668  1.000 5.69445   ? 135 LEU A C   1 
ATOM   1169 O O   . LEU B 2 137 ? 29.79102 -16.67071 10.91364  1.000 5.13445   ? 135 LEU A O   1 
ATOM   1170 C CB  . LEU B 2 137 ? 28.15041 -17.34314 13.55520  1.000 6.35445   ? 135 LEU A CB  1 
ATOM   1171 C CG  . LEU B 2 137 ? 28.11024 -18.31080 14.74500  1.000 7.03445   ? 135 LEU A CG  1 
ATOM   1172 C CD1 . LEU B 2 137 ? 26.67461 -18.55681 15.15503  1.000 7.77445   ? 135 LEU A CD1 1 
ATOM   1173 C CD2 . LEU B 2 137 ? 28.81073 -19.61113 14.41561  1.000 7.54445   ? 135 LEU A CD2 1 
ATOM   1174 N N   . ARG B 2 138 ? 29.27703 -14.73428 11.94357  1.000 5.90947   ? 136 ARG A N   1 
ATOM   1175 C CA  . ARG B 2 138 ? 29.29948 -13.97508 10.69823  1.000 7.07947   ? 136 ARG A CA  1 
ATOM   1176 C C   . ARG B 2 138 ? 30.72570 -13.84771 10.17229  1.000 6.45947   ? 136 ARG A C   1 
ATOM   1177 O O   . ARG B 2 138 ? 30.98001 -14.07231 8.97884   1.000 6.16947   ? 136 ARG A O   1 
ATOM   1178 C CB  . ARG B 2 138 ? 28.66949 -12.60782 10.94538  1.000 8.23947   ? 136 ARG A CB  1 
ATOM   1179 C CG  . ARG B 2 138 ? 28.53093 -11.69886 9.71354   1.000 11.06947  ? 136 ARG A CG  1 
ATOM   1180 C CD  . ARG B 2 138 ? 27.72728 -10.46009 10.10714  1.000 14.28947  ? 136 ARG A CD  1 
ATOM   1181 N NE  . ARG B 2 138 ? 27.56735 -9.55230  8.98025   1.000 18.46947  ? 136 ARG A NE  1 
ATOM   1182 C CZ  . ARG B 2 138 ? 28.33496 -8.49354  8.77315   1.000 22.67947  ? 136 ARG A CZ  1 
ATOM   1183 N NH1 . ARG B 2 138 ? 29.31613 -8.18111  9.60292   1.000 24.58947  ? 136 ARG A NH1 1 
ATOM   1184 N NH2 . ARG B 2 138 ? 28.10211 -7.71998  7.71716   1.000 24.71947  ? 136 ARG A NH2 1 
ATOM   1185 N N   . GLY B 2 139 ? 31.66794 -13.48475 11.05866  1.000 6.49673   ? 137 GLY A N   1 
ATOM   1186 C CA  . GLY B 2 139 ? 33.08271 -13.55447 10.71242  1.000 6.68673   ? 137 GLY A CA  1 
ATOM   1187 C C   . GLY B 2 139 ? 33.52337 -14.94751 10.28822  1.000 7.35673   ? 137 GLY A C   1 
ATOM   1188 O O   . GLY B 2 139 ? 34.31169 -15.09869 9.35291   1.000 6.97673   ? 137 GLY A O   1 
ATOM   1189 N N   . LEU B 2 140 ? 33.02142 -15.99420 10.96817  1.000 7.56923   ? 138 LEU A N   1 
ATOM   1190 C CA  . LEU B 2 140 ? 33.44549 -17.34916 10.61379  1.000 7.19923   ? 138 LEU A CA  1 
ATOM   1191 C C   . LEU B 2 140 ? 32.89929 -17.78499 9.25961   1.000 6.80923   ? 138 LEU A C   1 
ATOM   1192 O O   . LEU B 2 140 ? 33.58327 -18.50061 8.52380   1.000 6.89923   ? 138 LEU A O   1 
ATOM   1193 C CB  . LEU B 2 140 ? 33.02103 -18.35716 11.68539  1.000 7.37923   ? 138 LEU A CB  1 
ATOM   1194 C CG  . LEU B 2 140 ? 33.90798 -18.47781 12.92368  1.000 8.78923   ? 138 LEU A CG  1 
ATOM   1195 C CD1 . LEU B 2 140 ? 33.35979 -19.62156 13.76584  1.000 9.98923   ? 138 LEU A CD1 1 
ATOM   1196 C CD2 . LEU B 2 140 ? 35.33061 -18.78237 12.50959  1.000 9.28923   ? 138 LEU A CD2 1 
ATOM   1197 N N   . LYS B 2 141 ? 31.65441 -17.42515 8.93829   1.000 7.15512   ? 139 LYS A N   1 
ATOM   1198 C CA  . LYS B 2 141 ? 31.12947 -17.72455 7.60481   1.000 7.90512   ? 139 LYS A CA  1 
ATOM   1199 C C   . LYS B 2 141 ? 32.02419 -17.13755 6.51140   1.000 7.56512   ? 139 LYS A C   1 
ATOM   1200 O O   . LYS B 2 141 ? 32.31463 -17.80575 5.51177   1.000 7.81512   ? 139 LYS A O   1 
ATOM   1201 C CB  . LYS B 2 141 ? 29.70842 -17.18827 7.45242   1.000 8.36512   ? 139 LYS A CB  1 
ATOM   1202 C CG  . LYS B 2 141 ? 29.17107 -17.38678 6.02847   1.000 9.55512   ? 139 LYS A CG  1 
ATOM   1203 C CD  . LYS B 2 141 ? 27.87089 -16.64484 5.76258   1.000 12.07512  ? 139 LYS A CD  1 
ATOM   1204 C CE  . LYS B 2 141 ? 27.35280 -16.96708 4.35332   1.000 13.34512  ? 139 LYS A CE  1 
ATOM   1205 N NZ  . LYS B 2 141 ? 26.13292 -16.16362 4.03429   1.000 14.79512  ? 139 LYS A NZ  1 
ATOM   1206 N N   . TYR B 2 142 ? 32.49357 -15.90503 6.71278   1.000 7.40019   ? 140 TYR A N   1 
ATOM   1207 C CA  . TYR B 2 142 ? 33.43761 -15.27111 5.79349   1.000 8.60019   ? 140 TYR A CA  1 
ATOM   1208 C C   . TYR B 2 142 ? 34.74625 -16.05264 5.69064   1.000 9.29019   ? 140 TYR A C   1 
ATOM   1209 O O   . TYR B 2 142 ? 35.15134 -16.44460 4.59206   1.000 12.04019  ? 140 TYR A O   1 
ATOM   1210 C CB  . TYR B 2 142 ? 33.70707 -13.83928 6.24114   1.000 8.45019   ? 140 TYR A CB  1 
ATOM   1211 C CG  . TYR B 2 142 ? 34.74075 -13.09431 5.40850   1.000 9.68019   ? 140 TYR A CG  1 
ATOM   1212 C CD1 . TYR B 2 142 ? 34.37034 -12.43487 4.23133   1.000 9.71019   ? 140 TYR A CD1 1 
ATOM   1213 C CD2 . TYR B 2 142 ? 36.07510 -13.02976 5.81556   1.000 9.53019   ? 140 TYR A CD2 1 
ATOM   1214 C CE1 . TYR B 2 142 ? 35.30474 -11.73119 3.49331   1.000 10.45019  ? 140 TYR A CE1 1 
ATOM   1215 C CE2 . TYR B 2 142 ? 37.01548 -12.35232 5.07965   1.000 10.86019  ? 140 TYR A CE2 1 
ATOM   1216 C CZ  . TYR B 2 142 ? 36.63028 -11.71926 3.90897   1.000 10.90019  ? 140 TYR A CZ  1 
ATOM   1217 O OH  . TYR B 2 142 ? 37.56834 -11.03504 3.17386   1.000 15.48019  ? 140 TYR A OH  1 
ATOM   1218 N N   . ILE B 2 143 ? 35.42771 -16.29328 6.81765   1.000 9.07060   ? 141 ILE A N   1 
ATOM   1219 C CA  . ILE B 2 143 ? 36.73072 -16.94714 6.69154   1.000 10.50060  ? 141 ILE A CA  1 
ATOM   1220 C C   . ILE B 2 143 ? 36.58398 -18.38991 6.20426   1.000 9.72060   ? 141 ILE A C   1 
ATOM   1221 O O   . ILE B 2 143 ? 37.39985 -18.84643 5.39210   1.000 10.10060  ? 141 ILE A O   1 
ATOM   1222 C CB  . ILE B 2 143 ? 37.57581 -16.86617 7.98250   1.000 13.62060  ? 141 ILE A CB  1 
ATOM   1223 C CG1 . ILE B 2 143 ? 37.06711 -17.79310 9.07478   1.000 16.34060  ? 141 ILE A CG1 1 
ATOM   1224 C CG2 . ILE B 2 143 ? 37.63410 -15.42170 8.53331   1.000 16.58060  ? 141 ILE A CG2 1 
ATOM   1225 C CD1 . ILE B 2 143 ? 38.15707 -18.26688 10.01223  1.000 19.29060  ? 141 ILE A CD1 1 
ATOM   1226 N N   . HIS B 2 144 ? 35.51824 -19.09604 6.60191   1.000 9.64410   ? 142 HIS A N   1 
ATOM   1227 C CA  . HIS B 2 144 ? 35.35115 -20.46930 6.13733   1.000 10.82410  ? 142 HIS A CA  1 
ATOM   1228 C C   . HIS B 2 144 ? 35.05403 -20.53823 4.64779   1.000 11.97410  ? 142 HIS A C   1 
ATOM   1229 O O   . HIS B 2 144 ? 35.44230 -21.50781 3.99322   1.000 12.10410  ? 142 HIS A O   1 
ATOM   1230 C CB  . HIS B 2 144 ? 34.25208 -21.18045 6.93143   1.000 9.75410   ? 142 HIS A CB  1 
ATOM   1231 C CG  . HIS B 2 144 ? 34.65359 -21.49693 8.34007   1.000 10.90410  ? 142 HIS A CG  1 
ATOM   1232 N ND1 . HIS B 2 144 ? 33.77869 -22.01442 9.27061   1.000 10.23410  ? 142 HIS A ND1 1 
ATOM   1233 C CD2 . HIS B 2 144 ? 35.85061 -21.38054 8.96948   1.000 10.46410  ? 142 HIS A CD2 1 
ATOM   1234 C CE1 . HIS B 2 144 ? 34.41600 -22.19551 10.41439  1.000 11.14410  ? 142 HIS A CE1 1 
ATOM   1235 N NE2 . HIS B 2 144 ? 35.67346 -21.81753 10.25754  1.000 10.59410  ? 142 HIS A NE2 1 
ATOM   1236 N N   . SER B 2 145 ? 34.38237 -19.52445 4.09684   1.000 11.88049  ? 143 SER A N   1 
ATOM   1237 C CA  . SER B 2 145 ? 34.08784 -19.50022 2.66953   1.000 12.94049  ? 143 SER A CA  1 
ATOM   1238 C C   . SER B 2 145 ? 35.34949 -19.36509 1.82245   1.000 16.14049  ? 143 SER A C   1 
ATOM   1239 O O   . SER B 2 145 ? 35.32177 -19.71993 0.63997   1.000 17.71049  ? 143 SER A O   1 
ATOM   1240 C CB  . SER B 2 145 ? 33.11932 -18.36889 2.34889   1.000 13.00049  ? 143 SER A CB  1 
ATOM   1241 O OG  . SER B 2 145 ? 33.74541 -17.10309 2.48129   1.000 14.04049  ? 143 SER A OG  1 
ATOM   1242 N N   . ALA B 2 146 ? 36.45737 -18.91339 2.40800   1.000 14.26125  ? 144 ALA A N   1 
ATOM   1243 C CA  . ALA B 2 146 ? 37.74837 -18.85923 1.73646   1.000 17.77125  ? 144 ALA A CA  1 
ATOM   1244 C C   . ALA B 2 146 ? 38.63500 -20.04686 2.07840   1.000 18.84125  ? 144 ALA A C   1 
ATOM   1245 O O   . ALA B 2 146 ? 39.81856 -20.02259 1.74206   1.000 19.06125  ? 144 ALA A O   1 
ATOM   1246 C CB  . ALA B 2 146 ? 38.48625 -17.56945 2.09839   1.000 16.13125  ? 144 ALA A CB  1 
ATOM   1247 N N   . ASP B 2 147 ? 38.08823 -21.06572 2.75156   1.000 17.01652  ? 145 ASP A N   1 
ATOM   1248 C CA  . ASP B 2 147 ? 38.82567 -22.25462 3.19542   1.000 18.43652  ? 145 ASP A CA  1 
ATOM   1249 C C   . ASP B 2 147 ? 39.95868 -21.89400 4.15291   1.000 15.48652  ? 145 ASP A C   1 
ATOM   1250 O O   . ASP B 2 147 ? 41.02685 -22.51161 4.14929   1.000 14.97652  ? 145 ASP A O   1 
ATOM   1251 C CB  . ASP B 2 147 ? 39.33469 -23.07850 2.00865   1.000 26.05652  ? 145 ASP A CB  1 
ATOM   1252 C CG  . ASP B 2 147 ? 38.20702 -23.55017 1.11633   1.000 34.09652  ? 145 ASP A CG  1 
ATOM   1253 O OD1 . ASP B 2 147 ? 37.08613 -23.76338 1.63522   1.000 48.90652  ? 145 ASP A OD1 1 
ATOM   1254 O OD2 . ASP B 2 147 ? 38.43473 -23.70572 -0.09948  1.000 57.61652  ? 145 ASP A OD2 1 
ATOM   1255 N N   . ILE B 2 148 ? 39.71726 -20.88750 4.98980   1.000 13.51737  ? 146 ILE A N   1 
ATOM   1256 C CA  . ILE B 2 148 ? 40.60379 -20.52838 6.09129   1.000 14.12737  ? 146 ILE A CA  1 
ATOM   1257 C C   . ILE B 2 148 ? 40.00669 -21.11041 7.36761   1.000 17.35737  ? 146 ILE A C   1 
ATOM   1258 O O   . ILE B 2 148 ? 38.78532 -21.06849 7.56812   1.000 14.31737  ? 146 ILE A O   1 
ATOM   1259 C CB  . ILE B 2 148 ? 40.76512 -18.99710 6.18790   1.000 13.66737  ? 146 ILE A CB  1 
ATOM   1260 C CG1 . ILE B 2 148 ? 41.48224 -18.46556 4.93974   1.000 15.92737  ? 146 ILE A CG1 1 
ATOM   1261 C CG2 . ILE B 2 148 ? 41.52951 -18.58508 7.45172   1.000 15.30737  ? 146 ILE A CG2 1 
ATOM   1262 C CD1 . ILE B 2 148 ? 41.27422 -16.97130 4.67779   1.000 15.34737  ? 146 ILE A CD1 1 
ATOM   1263 N N   . ILE B 2 149 ? 40.84669 -21.70244 8.20852   1.000 17.01278  ? 147 ILE A N   1 
ATOM   1264 C CA  . ILE B 2 149 ? 40.42085 -22.19875 9.50848   1.000 18.16278  ? 147 ILE A CA  1 
ATOM   1265 C C   . ILE B 2 149 ? 41.15311 -21.38243 10.55669  1.000 17.80278  ? 147 ILE A C   1 
ATOM   1266 O O   . ILE B 2 149 ? 42.37361 -21.20730 10.46426  1.000 19.46278  ? 147 ILE A O   1 
ATOM   1267 C CB  . ILE B 2 149 ? 40.71103 -23.70437 9.66900   1.000 22.51278  ? 147 ILE A CB  1 
ATOM   1268 C CG1 . ILE B 2 149 ? 40.13592 -24.47989 8.48696   1.000 25.24278  ? 147 ILE A CG1 1 
ATOM   1269 C CG2 . ILE B 2 149 ? 40.14239 -24.23869 10.98949  1.000 21.36278  ? 147 ILE A CG2 1 
ATOM   1270 C CD1 . ILE B 2 149 ? 40.58929 -25.92190 8.42983   1.000 28.86278  ? 147 ILE A CD1 1 
ATOM   1271 N N   . HIS B 2 150 ? 40.41298 -20.85830 11.53645  1.000 15.48496  ? 148 HIS A N   1 
ATOM   1272 C CA  . HIS B 2 150 ? 41.07485 -20.06159 12.55618  1.000 16.26496  ? 148 HIS A CA  1 
ATOM   1273 C C   . HIS B 2 150 ? 41.98726 -20.92762 13.40348  1.000 16.58496  ? 148 HIS A C   1 
ATOM   1274 O O   . HIS B 2 150 ? 43.12259 -20.53522 13.68576  1.000 16.84496  ? 148 HIS A O   1 
ATOM   1275 C CB  . HIS B 2 150 ? 40.07237 -19.33676 13.44642  1.000 14.50496  ? 148 HIS A CB  1 
ATOM   1276 C CG  . HIS B 2 150 ? 40.72432 -18.39036 14.40698  1.000 14.18496  ? 148 HIS A CG  1 
ATOM   1277 N ND1 . HIS B 2 150 ? 41.38691 -18.80819 15.54363  1.000 14.25496  ? 148 HIS A ND1 1 
ATOM   1278 C CD2 . HIS B 2 150 ? 40.85374 -17.04550 14.37366  1.000 13.86496  ? 148 HIS A CD2 1 
ATOM   1279 C CE1 . HIS B 2 150 ? 41.87767 -17.75731 16.17684  1.000 15.67496  ? 148 HIS A CE1 1 
ATOM   1280 N NE2 . HIS B 2 150 ? 41.55602 -16.67447 15.49402  1.000 14.47496  ? 148 HIS A NE2 1 
ATOM   1281 N N   . ARG B 2 151 ? 41.47838 -22.08715 13.83763  1.000 14.66879  ? 149 ARG A N   1 
ATOM   1282 C CA  . ARG B 2 151 ? 42.12332 -23.14774 14.61971  1.000 19.54879  ? 149 ARG A CA  1 
ATOM   1283 C C   . ARG B 2 151 ? 42.28478 -22.83803 16.10253  1.000 20.09879  ? 149 ARG A C   1 
ATOM   1284 O O   . ARG B 2 151 ? 42.49672 -23.76697 16.89213  1.000 24.35879  ? 149 ARG A O   1 
ATOM   1285 C CB  . ARG B 2 151 ? 43.50184 -23.53303 14.06653  1.000 26.53879  ? 149 ARG A CB  1 
ATOM   1286 C CG  . ARG B 2 151 ? 43.51222 -24.04552 12.64427  1.000 34.97879  ? 149 ARG A CG  1 
ATOM   1287 C CD  . ARG B 2 151 ? 44.93919 -24.36716 12.20669  1.000 45.20879  ? 149 ARG A CD  1 
ATOM   1288 N NE  . ARG B 2 151 ? 44.96954 -25.08273 10.93592  1.000 55.94879  ? 149 ARG A NE  1 
ATOM   1289 C CZ  . ARG B 2 151 ? 44.92644 -24.49250 9.74980   1.000 49.27879  ? 149 ARG A CZ  1 
ATOM   1290 N NH1 . ARG B 2 151 ? 44.84468 -23.17641 9.63714   1.000 50.41879  ? 149 ARG A NH1 1 
ATOM   1291 N NH2 . ARG B 2 151 ? 44.96467 -25.24047 8.65079   1.000 48.88879  ? 149 ARG A NH2 1 
ATOM   1292 N N   . ASP B 2 152 ? 42.20717 -21.57772 16.51795  1.000 18.42111  ? 150 ASP A N   1 
ATOM   1293 C CA  . ASP B 2 152 ? 42.49038 -21.27282 17.92057  1.000 20.62111  ? 150 ASP A CA  1 
ATOM   1294 C C   . ASP B 2 152 ? 41.52818 -20.22273 18.47952  1.000 18.17111  ? 150 ASP A C   1 
ATOM   1295 O O   . ASP B 2 152 ? 41.92148 -19.29664 19.19299  1.000 16.60111  ? 150 ASP A O   1 
ATOM   1296 C CB  . ASP B 2 152 ? 43.94799 -20.84610 18.08591  1.000 24.51111  ? 150 ASP A CB  1 
ATOM   1297 C CG  . ASP B 2 152 ? 44.40044 -20.86652 19.54046  1.000 29.37111  ? 150 ASP A CG  1 
ATOM   1298 O OD1 . ASP B 2 152 ? 44.02100 -21.80717 20.28240  1.000 31.31111  ? 150 ASP A OD1 1 
ATOM   1299 O OD2 . ASP B 2 152 ? 45.10583 -19.91578 19.94508  1.000 40.51111  ? 150 ASP A OD2 1 
ATOM   1300 N N   . LEU B 2 153 ? 40.23362 -20.39811 18.21199  1.000 14.80788  ? 151 LEU A N   1 
ATOM   1301 C CA  . LEU B 2 153 ? 39.22308 -19.51215 18.77803  1.000 12.70788  ? 151 LEU A CA  1 
ATOM   1302 C C   . LEU B 2 153 ? 39.08869 -19.72986 20.27455  1.000 12.20788  ? 151 LEU A C   1 
ATOM   1303 O O   . LEU B 2 153 ? 38.87896 -20.85219 20.73329  1.000 14.64788  ? 151 LEU A O   1 
ATOM   1304 C CB  . LEU B 2 153 ? 37.86886 -19.74897 18.12201  1.000 15.00788  ? 151 LEU A CB  1 
ATOM   1305 C CG  . LEU B 2 153 ? 37.62580 -19.24748 16.71610  1.000 18.94788  ? 151 LEU A CG  1 
ATOM   1306 C CD1 . LEU B 2 153 ? 36.23810 -19.67190 16.27925  1.000 18.05788  ? 151 LEU A CD1 1 
ATOM   1307 C CD2 . LEU B 2 153 ? 37.78257 -17.71556 16.67155  1.000 18.57788  ? 151 LEU A CD2 1 
ATOM   1308 N N   . LYS B 2 154 ? 39.15403 -18.64205 21.02424  1.000 10.93925  ? 152 LYS A N   1 
ATOM   1309 C CA  . LYS B 2 154 ? 38.98136 -18.63344 22.46526  1.000 12.42925  ? 152 LYS A CA  1 
ATOM   1310 C C   . LYS B 2 154 ? 38.65549 -17.20661 22.84745  1.000 10.58925  ? 152 LYS A C   1 
ATOM   1311 O O   . LYS B 2 154 ? 38.84965 -16.30249 22.02276  1.000 11.69925  ? 152 LYS A O   1 
ATOM   1312 C CB  . LYS B 2 154 ? 40.24699 -19.15369 23.17544  1.000 15.60925  ? 152 LYS A CB  1 
ATOM   1313 C CG  . LYS B 2 154 ? 41.52101 -18.44290 22.82256  1.000 18.82925  ? 152 LYS A CG  1 
ATOM   1314 C CD  . LYS B 2 154 ? 42.69914 -19.28654 23.29154  1.000 24.03925  ? 152 LYS A CD  1 
ATOM   1315 C CE  . LYS B 2 154 ? 44.01555 -18.62612 22.95826  1.000 33.37925  ? 152 LYS A CE  1 
ATOM   1316 N NZ  . LYS B 2 154 ? 45.14305 -19.59167 23.10560  1.000 41.16925  ? 152 LYS A NZ  1 
ATOM   1317 N N   . PRO B 2 155 ? 38.09647 -16.96560 24.04272  1.000 11.98698  ? 153 PRO A N   1 
ATOM   1318 C CA  . PRO B 2 155 ? 37.68099 -15.59060 24.37448  1.000 13.13698  ? 153 PRO A CA  1 
ATOM   1319 C C   . PRO B 2 155 ? 38.80296 -14.55907 24.31007  1.000 14.90698  ? 153 PRO A C   1 
ATOM   1320 O O   . PRO B 2 155 ? 38.53938 -13.40538 23.93638  1.000 14.52698  ? 153 PRO A O   1 
ATOM   1321 C CB  . PRO B 2 155 ? 37.12364 -15.73351 25.80087  1.000 14.51698  ? 153 PRO A CB  1 
ATOM   1322 C CG  . PRO B 2 155 ? 36.58224 -17.13229 25.82306  1.000 14.27698  ? 153 PRO A CG  1 
ATOM   1323 C CD  . PRO B 2 155 ? 37.61713 -17.91697 25.06843  1.000 14.39698  ? 153 PRO A CD  1 
ATOM   1324 N N   . SER B 2 156 ? 40.05085 -14.95267 24.59154  1.000 14.19187  ? 154 SER A N   1 
ATOM   1325 C CA  . SER B 2 156 ? 41.15429 -13.99854 24.51206  1.000 17.12187  ? 154 SER A CA  1 
ATOM   1326 C C   . SER B 2 156 ? 41.50870 -13.61379 23.07676  1.000 18.36187  ? 154 SER A C   1 
ATOM   1327 O O   . SER B 2 156 ? 42.30570 -12.69157 22.88644  1.000 19.26187  ? 154 SER A O   1 
ATOM   1328 C CB  . SER B 2 156 ? 42.38852 -14.56054 25.22420  1.000 15.57187  ? 154 SER A CB  1 
ATOM   1329 O OG  . SER B 2 156 ? 42.89058 -15.69141 24.53477  1.000 17.80187  ? 154 SER A OG  1 
ATOM   1330 N N   . ASN B 2 157 ? 40.94638 -14.28674 22.06868  1.000 15.96346  ? 155 ASN A N   1 
ATOM   1331 C CA  . ASN B 2 157 ? 41.16438 -13.93394 20.67083  1.000 17.18346  ? 155 ASN A CA  1 
ATOM   1332 C C   . ASN B 2 157 ? 40.00097 -13.17062 20.06288  1.000 13.64346  ? 155 ASN A C   1 
ATOM   1333 O O   . ASN B 2 157 ? 39.94230 -13.02334 18.84358  1.000 15.55346  ? 155 ASN A O   1 
ATOM   1334 C CB  . ASN B 2 157 ? 41.45461 -15.18745 19.84658  1.000 19.89346  ? 155 ASN A CB  1 
ATOM   1335 C CG  . ASN B 2 157 ? 42.86039 -15.67553 20.06250  1.000 26.10346  ? 155 ASN A CG  1 
ATOM   1336 O OD1 . ASN B 2 157 ? 43.73269 -14.89208 20.47509  1.000 27.97346  ? 155 ASN A OD1 1 
ATOM   1337 N ND2 . ASN B 2 157 ? 43.09886 -16.95774 19.82289  1.000 22.10346  ? 155 ASN A ND2 1 
ATOM   1338 N N   . LEU B 2 158 ? 39.07402 -12.69213 20.87105  1.000 12.14210  ? 156 LEU A N   1 
ATOM   1339 C CA  . LEU B 2 158 ? 37.89740 -11.99375 20.37276  1.000 12.61210  ? 156 LEU A CA  1 
ATOM   1340 C C   . LEU B 2 158 ? 37.91436 -10.61323 20.99496  1.000 13.80210  ? 156 LEU A C   1 
ATOM   1341 O O   . LEU B 2 158 ? 37.77909 -10.48947 22.21376  1.000 16.29210  ? 156 LEU A O   1 
ATOM   1342 C CB  . LEU B 2 158 ? 36.61274 -12.74725 20.73292  1.000 13.01210  ? 156 LEU A CB  1 
ATOM   1343 C CG  . LEU B 2 158 ? 36.58808 -14.16487 20.15592  1.000 14.67210  ? 156 LEU A CG  1 
ATOM   1344 C CD1 . LEU B 2 158 ? 35.45910 -15.00009 20.76583  1.000 18.52210  ? 156 LEU A CD1 1 
ATOM   1345 C CD2 . LEU B 2 158 ? 36.50432 -14.15458 18.62456  1.000 13.99210  ? 156 LEU A CD2 1 
ATOM   1346 N N   . ALA B 2 159 ? 38.10700 -9.58559  20.17309  1.000 13.41658  ? 157 ALA A N   1 
ATOM   1347 C CA  . ALA B 2 159 ? 38.12499 -8.20944  20.64079  1.000 13.98658  ? 157 ALA A CA  1 
ATOM   1348 C C   . ALA B 2 159 ? 36.71313 -7.66054  20.59017  1.000 13.56658  ? 157 ALA A C   1 
ATOM   1349 O O   . ALA B 2 159 ? 35.97954 -7.92416  19.64263  1.000 14.15658  ? 157 ALA A O   1 
ATOM   1350 C CB  . ALA B 2 159 ? 39.05668 -7.35171  19.77549  1.000 14.78658  ? 157 ALA A CB  1 
ATOM   1351 N N   . VAL B 2 160 ? 36.32489 -6.91893  21.62740  1.000 13.28024  ? 158 VAL A N   1 
ATOM   1352 C CA  . VAL B 2 160 ? 34.97253 -6.38087  21.76647  1.000 14.92024  ? 158 VAL A CA  1 
ATOM   1353 C C   . VAL B 2 160 ? 35.08502 -4.92238  22.19810  1.000 17.66024  ? 158 VAL A C   1 
ATOM   1354 O O   . VAL B 2 160 ? 35.81204 -4.61988  23.15043  1.000 19.18024  ? 158 VAL A O   1 
ATOM   1355 C CB  . VAL B 2 160 ? 34.13727 -7.18320  22.79302  1.000 15.51024  ? 158 VAL A CB  1 
ATOM   1356 C CG1 . VAL B 2 160 ? 32.76051 -6.59785  22.93803  1.000 16.71024  ? 158 VAL A CG1 1 
ATOM   1357 C CG2 . VAL B 2 160 ? 34.03243 -8.67955  22.40207  1.000 18.29024  ? 158 VAL A CG2 1 
ATOM   1358 N N   . ASN B 2 161 ? 34.37168 -4.01790  21.51313  1.000 17.56845  ? 159 ASN A N   1 
ATOM   1359 C CA  . ASN B 2 161 ? 34.41291 -2.60827  21.89851  1.000 20.53845  ? 159 ASN A CA  1 
ATOM   1360 C C   . ASN B 2 161 ? 33.18843 -2.23123  22.73964  1.000 24.66845  ? 159 ASN A C   1 
ATOM   1361 O O   . ASN B 2 161 ? 32.36867 -3.08021  23.11166  1.000 19.96845  ? 159 ASN A O   1 
ATOM   1362 C CB  . ASN B 2 161 ? 34.58050 -1.68591  20.67268  1.000 19.42845  ? 159 ASN A CB  1 
ATOM   1363 C CG  . ASN B 2 161 ? 33.40469 -1.71975  19.68575  1.000 21.37845  ? 159 ASN A CG  1 
ATOM   1364 O OD1 . ASN B 2 161 ? 32.25121 -2.01259  20.02663  1.000 21.03845  ? 159 ASN A OD1 1 
ATOM   1365 N ND2 . ASN B 2 161 ? 33.70716 -1.38230  18.43102  1.000 21.62845  ? 159 ASN A ND2 1 
ATOM   1366 N N   . GLU B 2 162 ? 33.04308 -0.92535  23.01266  1.000 23.27696  ? 160 GLU A N   1 
ATOM   1367 C CA  . GLU B 2 162 ? 31.99132 -0.43604  23.89836  1.000 26.87696  ? 160 GLU A CA  1 
ATOM   1368 C C   . GLU B 2 162 ? 30.61944 -0.53282  23.27289  1.000 21.54696  ? 160 GLU A C   1 
ATOM   1369 O O   . GLU B 2 162 ? 29.61694 -0.42425  23.99117  1.000 22.35696  ? 160 GLU A O   1 
ATOM   1370 C CB  . GLU B 2 162 ? 32.25404 1.01556   24.29824  1.000 35.49696  ? 160 GLU A CB  1 
ATOM   1371 C CG  . GLU B 2 162 ? 33.30061 1.17204   25.37808  1.000 48.71696  ? 160 GLU A CG  1 
ATOM   1372 C CD  . GLU B 2 162 ? 33.73117 2.61986   25.55844  1.000 63.80696  ? 160 GLU A CD  1 
ATOM   1373 O OE1 . GLU B 2 162 ? 33.95185 3.31121   24.53365  1.000 55.99696  ? 160 GLU A OE1 1 
ATOM   1374 O OE2 . GLU B 2 162 ? 33.83678 3.06559   26.72417  1.000 72.94696  ? 160 GLU A OE2 1 
ATOM   1375 N N   . ASP B 2 163 ? 30.54617 -0.69848  21.95462  1.000 18.65864  ? 161 ASP A N   1 
ATOM   1376 C CA  . ASP B 2 163 ? 29.27728 -0.90899  21.28044  1.000 18.29864  ? 161 ASP A CA  1 
ATOM   1377 C C   . ASP B 2 163 ? 28.92730 -2.38462  21.15614  1.000 15.94864  ? 161 ASP A C   1 
ATOM   1378 O O   . ASP B 2 163 ? 27.98828 -2.71329  20.42480  1.000 15.31864  ? 161 ASP A O   1 
ATOM   1379 C CB  . ASP B 2 163 ? 29.29247 -0.26936  19.88563  1.000 24.18864  ? 161 ASP A CB  1 
ATOM   1380 C CG  . ASP B 2 163 ? 29.34940 1.25211   19.93916  1.000 34.23864  ? 161 ASP A CG  1 
ATOM   1381 O OD1 . ASP B 2 163 ? 28.68827 1.84570   20.81972  1.000 38.39864  ? 161 ASP A OD1 1 
ATOM   1382 O OD2 . ASP B 2 163 ? 30.06210 1.85431   19.10728  1.000 45.42864  ? 161 ASP A OD2 1 
ATOM   1383 N N   . CYS B 2 164 ? 29.67301 -3.26703  21.84066  1.000 16.13857  ? 162 CYS A N   1 
ATOM   1384 C CA  . CYS B 2 164 ? 29.50637 -4.72161  21.78201  1.000 15.10857  ? 162 CYS A CA  1 
ATOM   1385 C C   . CYS B 2 164 ? 29.81677 -5.27310  20.38097  1.000 16.26857  ? 162 CYS A C   1 
ATOM   1386 O O   . CYS B 2 164 ? 29.37794 -6.37794  20.02534  1.000 14.09857  ? 162 CYS A O   1 
ATOM   1387 C CB  . CYS B 2 164 ? 28.09718 -5.13654  22.25496  1.000 17.24857  ? 162 CYS A CB  1 
ATOM   1388 S SG  . CYS B 2 164 ? 27.85160 -6.86425  22.75590  1.000 20.82857  ? 162 CYS A SG  1 
ATOM   1389 N N   . GLU B 2 165 ? 30.58130 -4.51798  19.57944  1.000 14.56513  ? 163 GLU A N   1 
ATOM   1390 C CA  . GLU B 2 165 ? 31.01691 -4.97618  18.26245  1.000 16.06513  ? 163 GLU A CA  1 
ATOM   1391 C C   . GLU B 2 165 ? 32.26139 -5.83927  18.40476  1.000 13.12513  ? 163 GLU A C   1 
ATOM   1392 O O   . GLU B 2 165 ? 33.12918 -5.56664  19.23287  1.000 14.66513  ? 163 GLU A O   1 
ATOM   1393 C CB  . GLU B 2 165 ? 31.29217 -3.78617  17.33310  1.000 16.67513  ? 163 GLU A CB  1 
ATOM   1394 C CG  . GLU B 2 165 ? 30.04489 -2.96314  17.00194  1.000 22.57513  ? 163 GLU A CG  1 
ATOM   1395 C CD  . GLU B 2 165 ? 30.35438 -1.65316  16.26500  1.000 27.45513  ? 163 GLU A CD  1 
ATOM   1396 O OE1 . GLU B 2 165 ? 31.47397 -1.12604  16.42258  1.000 27.08513  ? 163 GLU A OE1 1 
ATOM   1397 O OE2 . GLU B 2 165 ? 29.47206 -1.14692  15.53742  1.000 33.89513  ? 163 GLU A OE2 1 
ATOM   1398 N N   . LEU B 2 166 ? 32.35268 -6.88834  17.59749  1.000 11.19172  ? 164 LEU A N   1 
ATOM   1399 C CA  . LEU B 2 166 ? 33.35455 -7.91291  17.82485  1.000 10.00172  ? 164 LEU A CA  1 
ATOM   1400 C C   . LEU B 2 166 ? 34.20087 -8.13239  16.57798  1.000 8.77172   ? 164 LEU A C   1 
ATOM   1401 O O   . LEU B 2 166 ? 33.70481 -8.06915  15.45709  1.000 7.83172   ? 164 LEU A O   1 
ATOM   1402 C CB  . LEU B 2 166 ? 32.68145 -9.22384  18.26314  1.000 9.40172   ? 164 LEU A CB  1 
ATOM   1403 C CG  . LEU B 2 166 ? 33.50664 -10.48304 18.50308  1.000 8.39172   ? 164 LEU A CG  1 
ATOM   1404 C CD1 . LEU B 2 166 ? 32.82237 -11.29474 19.59924  1.000 8.51172   ? 164 LEU A CD1 1 
ATOM   1405 C CD2 . LEU B 2 166 ? 33.64324 -11.32963 17.20802  1.000 8.83172   ? 164 LEU A CD2 1 
ATOM   1406 N N   . LYS B 2 167 ? 35.47017 -8.46023  16.79626  1.000 9.16634   ? 165 LYS A N   1 
ATOM   1407 C CA  . LYS B 2 167 ? 36.38009 -8.87536  15.73609  1.000 10.50634  ? 165 LYS A CA  1 
ATOM   1408 C C   . LYS B 2 167 ? 37.13904 -10.11395 16.16708  1.000 9.05634   ? 165 LYS A C   1 
ATOM   1409 O O   . LYS B 2 167 ? 37.60757 -10.20003 17.30965  1.000 9.07634   ? 165 LYS A O   1 
ATOM   1410 C CB  . LYS B 2 167 ? 37.40818 -7.78897  15.39819  1.000 14.46634  ? 165 LYS A CB  1 
ATOM   1411 C CG  . LYS B 2 167 ? 36.87556 -6.63682  14.58124  1.000 21.87634  ? 165 LYS A CG  1 
ATOM   1412 C CD  . LYS B 2 167 ? 38.01081 -5.67160  14.18657  1.000 26.08634  ? 165 LYS A CD  1 
ATOM   1413 C CE  . LYS B 2 167 ? 37.44723 -4.35250  13.67473  1.000 27.16634  ? 165 LYS A CE  1 
ATOM   1414 N NZ  . LYS B 2 167 ? 36.61572 -4.54630  12.46654  1.000 27.09634  ? 165 LYS A NZ  1 
ATOM   1415 N N   . ILE B 2 168 ? 37.28936 -11.04329 15.23669  1.000 8.99953   ? 166 ILE A N   1 
ATOM   1416 C CA  . ILE B 2 168 ? 38.13335 -12.21450 15.42590  1.000 10.05953  ? 166 ILE A CA  1 
ATOM   1417 C C   . ILE B 2 168 ? 39.58212 -11.83990 15.14004  1.000 11.96953  ? 166 ILE A C   1 
ATOM   1418 O O   . ILE B 2 168 ? 39.90323 -11.36221 14.04565  1.000 11.68953  ? 166 ILE A O   1 
ATOM   1419 C CB  . ILE B 2 168 ? 37.67728 -13.34754 14.50104  1.000 10.22953  ? 166 ILE A CB  1 
ATOM   1420 C CG1 . ILE B 2 168 ? 36.22120 -13.74837 14.79727  1.000 10.27953  ? 166 ILE A CG1 1 
ATOM   1421 C CG2 . ILE B 2 168 ? 38.60626 -14.52318 14.61604  1.000 10.08953  ? 166 ILE A CG2 1 
ATOM   1422 C CD1 . ILE B 2 168 ? 35.63982 -14.64042 13.70444  1.000 10.63953  ? 166 ILE A CD1 1 
ATOM   1423 N N   . LEU B 2 169 ? 40.46707 -12.11218 16.09894  1.000 16.00984  ? 167 LEU A N   1 
ATOM   1424 C CA  . LEU B 2 169 ? 41.88315 -11.76139 16.03904  1.000 19.67984  ? 167 LEU A CA  1 
ATOM   1425 C C   . LEU B 2 169 ? 42.74685 -13.01629 16.11327  1.000 20.38984  ? 167 LEU A C   1 
ATOM   1426 O O   . LEU B 2 169 ? 42.24942 -14.12454 16.33024  1.000 17.28984  ? 167 LEU A O   1 
ATOM   1427 C CB  . LEU B 2 169 ? 42.26046 -10.81331 17.19152  1.000 23.30984  ? 167 LEU A CB  1 
ATOM   1428 C CG  . LEU B 2 169 ? 42.14662 -9.29781  17.01496  1.000 30.93984  ? 167 LEU A CG  1 
ATOM   1429 C CD1 . LEU B 2 169 ? 40.73649 -8.83726  16.72326  1.000 33.25984  ? 167 LEU A CD1 1 
ATOM   1430 C CD2 . LEU B 2 169 ? 42.68826 -8.58015  18.24800  1.000 34.64984  ? 167 LEU A CD2 1 
ATOM   1431 N N   . ASP B 2 170 ? 44.05921 -12.81896 15.90629  1.000 21.91700  ? 168 ASP A N   1 
ATOM   1432 C CA  . ASP B 2 170 ? 45.11530 -13.77953 16.27330  1.000 22.98700  ? 168 ASP A CA  1 
ATOM   1433 C C   . ASP B 2 170 ? 44.89104 -15.16405 15.65339  1.000 22.17700  ? 168 ASP A C   1 
ATOM   1434 O O   . ASP B 2 170 ? 44.70742 -16.16055 16.35568  1.000 20.33700  ? 168 ASP A O   1 
ATOM   1435 C CB  . ASP B 2 170 ? 45.24056 -13.90233 17.80135  1.000 28.37700  ? 168 ASP A CB  1 
ATOM   1436 C CG  . ASP B 2 170 ? 45.70840 -12.61791 18.47211  1.000 38.04700  ? 168 ASP A CG  1 
ATOM   1437 O OD1 . ASP B 2 170 ? 46.45013 -11.84270 17.82984  1.000 53.37700  ? 168 ASP A OD1 1 
ATOM   1438 O OD2 . ASP B 2 170 ? 45.34004 -12.38609 19.65298  1.000 45.93700  ? 168 ASP A OD2 1 
ATOM   1439 N N   . PHE B 2 171 ? 44.88522 -15.20873 14.32382  1.000 19.70810  ? 169 PHE A N   1 
ATOM   1440 C CA  . PHE B 2 171 ? 44.67435 -16.46530 13.61272  1.000 21.81810  ? 169 PHE A CA  1 
ATOM   1441 C C   . PHE B 2 171 ? 45.81560 -17.44355 13.86540  1.000 25.87810  ? 169 PHE A C   1 
ATOM   1442 O O   . PHE B 2 171 ? 46.97335 -17.05252 14.01455  1.000 24.71810  ? 169 PHE A O   1 
ATOM   1443 C CB  . PHE B 2 171 ? 44.55280 -16.22166 12.11078  1.000 20.09810  ? 169 PHE A CB  1 
ATOM   1444 C CG  . PHE B 2 171 ? 43.19166 -15.76322 11.68826  1.000 19.38810  ? 169 PHE A CG  1 
ATOM   1445 C CD1 . PHE B 2 171 ? 42.66571 -14.57125 12.17297  1.000 20.70810  ? 169 PHE A CD1 1 
ATOM   1446 C CD2 . PHE B 2 171 ? 42.43447 -16.52445 10.81873  1.000 17.69810  ? 169 PHE A CD2 1 
ATOM   1447 C CE1 . PHE B 2 171 ? 41.40424 -14.14420 11.79793  1.000 20.59810  ? 169 PHE A CE1 1 
ATOM   1448 C CE2 . PHE B 2 171 ? 41.17416 -16.09912 10.43381  1.000 18.41810  ? 169 PHE A CE2 1 
ATOM   1449 C CZ  . PHE B 2 171 ? 40.66144 -14.90726 10.92914  1.000 19.67810  ? 169 PHE A CZ  1 
ATOM   1450 N N   . GLY B 2 172 ? 45.47161 -18.73007 13.91190  1.000 25.62024  ? 170 GLY A N   1 
ATOM   1451 C CA  . GLY B 2 172 ? 46.47244 -19.76665 14.09269  1.000 31.16024  ? 170 GLY A CA  1 
ATOM   1452 C C   . GLY B 2 172 ? 47.31170 -19.92463 12.84044  1.000 35.54024  ? 170 GLY A C   1 
ATOM   1453 O O   . GLY B 2 172 ? 46.78454 -20.28912 11.77570  1.000 41.63024  ? 170 GLY A O   1 
ATOM   1454 N N   . LEU B 2 173 ? 48.61679 -19.66394 12.94595  1.000 32.79640  ? 171 LEU A N   1 
ATOM   1455 C CA  . LEU B 2 173 ? 49.52370 -19.70463 11.80425  1.000 40.28640  ? 171 LEU A CA  1 
ATOM   1456 C C   . LEU B 2 173 ? 50.28647 -21.02154 11.68313  1.000 45.14640  ? 171 LEU A C   1 
ATOM   1457 O O   . LEU B 2 173 ? 51.15749 -21.13325 10.80990  1.000 44.45640  ? 171 LEU A O   1 
ATOM   1458 C CB  . LEU B 2 173 ? 50.51013 -18.53270 11.87860  1.000 37.85640  ? 171 LEU A CB  1 
ATOM   1459 C CG  . LEU B 2 173 ? 49.84995 -17.15228 11.81806  1.000 44.20640  ? 171 LEU A CG  1 
ATOM   1460 C CD1 . LEU B 2 173 ? 50.82677 -16.05975 12.24243  1.000 43.83640  ? 171 LEU A CD1 1 
ATOM   1461 C CD2 . LEU B 2 173 ? 49.26952 -16.88291 10.42124  1.000 41.06640  ? 171 LEU A CD2 1 
ATOM   1462 N N   . ALA B 2 174 ? 50.00106 -21.99297 12.55540  1.000 45.03074  ? 172 ALA A N   1 
ATOM   1463 C CA  . ALA B 2 174 ? 50.35822 -23.41463 12.39100  1.000 47.93074  ? 172 ALA A CA  1 
ATOM   1464 C C   . ALA B 2 174 ? 51.84157 -23.69301 12.12301  1.000 55.06074  ? 172 ALA A C   1 
ATOM   1465 O O   . ALA B 2 174 ? 52.19159 -24.35651 11.14099  1.000 63.51074  ? 172 ALA A O   1 
ATOM   1466 C CB  . ALA B 2 174 ? 49.50479 -24.02928 11.27783  1.000 41.35074  ? 172 ALA A CB  1 
ATOM   1467 N N   . ALA B 2 186 ? 49.27979 -23.31212 26.41614  1.000 50.71722  ? 184 ALA A N   1 
ATOM   1468 C CA  . ALA B 2 186 ? 48.06431 -22.56057 26.10194  1.000 51.25722  ? 184 ALA A CA  1 
ATOM   1469 C C   . ALA B 2 186 ? 46.82829 -23.36500 26.48698  1.000 47.31722  ? 184 ALA A C   1 
ATOM   1470 O O   . ALA B 2 186 ? 46.91293 -24.57620 26.70520  1.000 45.16722  ? 184 ALA A O   1 
ATOM   1471 C CB  . ALA B 2 186 ? 48.02683 -22.19336 24.62221  1.000 50.81722  ? 184 ALA A CB  1 
ATOM   1472 N N   . THR B 2 187 ? 45.67928 -22.69864 26.57452  1.000 45.94390  ? 185 THR A N   1 
ATOM   1473 C CA  . THR B 2 187 ? 44.47337 -23.38024 27.02528  1.000 43.47390  ? 185 THR A CA  1 
ATOM   1474 C C   . THR B 2 187 ? 43.91679 -24.28353 25.92180  1.000 38.12390  ? 185 THR A C   1 
ATOM   1475 O O   . THR B 2 187 ? 43.95500 -23.95021 24.72892  1.000 32.56390  ? 185 THR A O   1 
ATOM   1476 C CB  . THR B 2 187 ? 43.42511 -22.36492 27.50647  1.000 43.39390  ? 185 THR A CB  1 
ATOM   1477 O OG1 . THR B 2 187 ? 42.30041 -23.05642 28.05904  1.000 43.59390  ? 185 THR A OG1 1 
ATOM   1478 C CG2 . THR B 2 187 ? 42.94737 -21.43997 26.37748  1.000 44.71390  ? 185 THR A CG2 1 
ATOM   1479 N N   . ARG B 2 188 ? 43.45459 -25.46753 26.33222  1.000 36.66044  ? 186 ARG A N   1 
ATOM   1480 C CA  . ARG B 2 188 ? 42.82119 -26.44561 25.45785  1.000 33.10044  ? 186 ARG A CA  1 
ATOM   1481 C C   . ARG B 2 188 ? 41.31989 -26.49231 25.65074  1.000 19.27044  ? 186 ARG A C   1 
ATOM   1482 O O   . ARG B 2 188 ? 40.64801 -27.28322 24.98394  1.000 25.54044  ? 186 ARG A O   1 
ATOM   1483 C CB  . ARG B 2 188 ? 43.37784 -27.84615 25.72407  1.000 41.68044  ? 186 ARG A CB  1 
ATOM   1484 C CG  . ARG B 2 188 ? 44.84183 -28.04383 25.44243  1.000 46.54044  ? 186 ARG A CG  1 
ATOM   1485 C CD  . ARG B 2 188 ? 45.28562 -29.41412 25.95883  1.000 53.19044  ? 186 ARG A CD  1 
ATOM   1486 N NE  . ARG B 2 188 ? 45.39021 -29.43904 27.41420  1.000 50.09044  ? 186 ARG A NE  1 
ATOM   1487 C CZ  . ARG B 2 188 ? 46.49785 -29.13686 28.07715  1.000 45.91044  ? 186 ARG A CZ  1 
ATOM   1488 N NH1 . ARG B 2 188 ? 47.61187 -28.80636 27.44290  1.000 47.52044  ? 186 ARG A NH1 1 
ATOM   1489 N NH2 . ARG B 2 188 ? 46.48604 -29.15878 29.40621  1.000 42.25044  ? 186 ARG A NH2 1 
ATOM   1490 N N   . TRP B 2 189 ? 40.79266 -25.66526 26.55235  1.000 18.13403  ? 187 TRP A N   1 
ATOM   1491 C CA  . TRP B 2 189 ? 39.39479 -25.70246 26.95344  1.000 18.19403  ? 187 TRP A CA  1 
ATOM   1492 C C   . TRP B 2 189 ? 38.41909 -25.47840 25.79934  1.000 16.49403  ? 187 TRP A C   1 
ATOM   1493 O O   . TRP B 2 189 ? 37.23913 -25.80387 25.94193  1.000 18.74403  ? 187 TRP A O   1 
ATOM   1494 C CB  . TRP B 2 189 ? 39.14307 -24.63892 28.01479  1.000 17.54403  ? 187 TRP A CB  1 
ATOM   1495 C CG  . TRP B 2 189 ? 39.89032 -24.83991 29.29310  1.000 20.78403  ? 187 TRP A CG  1 
ATOM   1496 C CD1 . TRP B 2 189 ? 40.57994 -25.94795 29.67737  1.000 20.34403  ? 187 TRP A CD1 1 
ATOM   1497 C CD2 . TRP B 2 189 ? 40.01749 -23.89317 30.35349  1.000 20.07403  ? 187 TRP A CD2 1 
ATOM   1498 N NE1 . TRP B 2 189 ? 41.12115 -25.75657 30.93043  1.000 21.52403  ? 187 TRP A NE1 1 
ATOM   1499 C CE2 . TRP B 2 189 ? 40.79098 -24.49808 31.36449  1.000 23.05403  ? 187 TRP A CE2 1 
ATOM   1500 C CE3 . TRP B 2 189 ? 39.55670 -22.59115 30.54694  1.000 22.08403  ? 187 TRP A CE3 1 
ATOM   1501 C CZ2 . TRP B 2 189 ? 41.10730 -23.84276 32.55396  1.000 24.51403  ? 187 TRP A CZ2 1 
ATOM   1502 C CZ3 . TRP B 2 189 ? 39.86017 -21.94872 31.74375  1.000 26.78403  ? 187 TRP A CZ3 1 
ATOM   1503 C CH2 . TRP B 2 189 ? 40.62894 -22.57334 32.72314  1.000 22.98403  ? 187 TRP A CH2 1 
ATOM   1504 N N   . TYR B 2 190 ? 38.87389 -24.90456 24.68429  1.000 14.42371  ? 188 TYR A N   1 
ATOM   1505 C CA  . TYR B 2 190 ? 37.99515 -24.52500 23.58505  1.000 16.18371  ? 188 TYR A CA  1 
ATOM   1506 C C   . TYR B 2 190 ? 38.30652 -25.32559 22.33732  1.000 16.72371  ? 188 TYR A C   1 
ATOM   1507 O O   . TYR B 2 190 ? 37.71389 -25.07111 21.28373  1.000 16.08371  ? 188 TYR A O   1 
ATOM   1508 C CB  . TYR B 2 190 ? 38.10339 -23.01405 23.30982  1.000 14.05371  ? 188 TYR A CB  1 
ATOM   1509 C CG  . TYR B 2 190 ? 37.84584 -22.19650 24.56072  1.000 12.84371  ? 188 TYR A CG  1 
ATOM   1510 C CD1 . TYR B 2 190 ? 36.55735 -21.83986 24.93232  1.000 12.37371  ? 188 TYR A CD1 1 
ATOM   1511 C CD2 . TYR B 2 190 ? 38.90019 -21.79953 25.38503  1.000 13.18371  ? 188 TYR A CD2 1 
ATOM   1512 C CE1 . TYR B 2 190 ? 36.32556 -21.11453 26.09796  1.000 11.92371  ? 188 TYR A CE1 1 
ATOM   1513 C CE2 . TYR B 2 190 ? 38.67664 -21.08273 26.53892  1.000 12.70371  ? 188 TYR A CE2 1 
ATOM   1514 C CZ  . TYR B 2 190 ? 37.39444 -20.74465 26.89047  1.000 13.14371  ? 188 TYR A CZ  1 
ATOM   1515 O OH  . TYR B 2 190 ? 37.18267 -20.01516 28.03935  1.000 15.05371  ? 188 TYR A OH  1 
ATOM   1516 N N   . ARG B 2 191 ? 39.19419 -26.31461 22.44446  1.000 14.62606  ? 189 ARG A N   1 
ATOM   1517 C CA  . ARG B 2 191 ? 39.69769 -27.04028 21.29343  1.000 16.49606  ? 189 ARG A CA  1 
ATOM   1518 C C   . ARG B 2 191 ? 38.85146 -28.28363 21.04327  1.000 15.78606  ? 189 ARG A C   1 
ATOM   1519 O O   . ARG B 2 191 ? 38.47351 -28.99259 21.98117  1.000 19.12606  ? 189 ARG A O   1 
ATOM   1520 C CB  . ARG B 2 191 ? 41.16738 -27.41330 21.51024  1.000 23.98606  ? 189 ARG A CB  1 
ATOM   1521 C CG  . ARG B 2 191 ? 41.84012 -27.91882 20.25929  1.000 34.45606  ? 189 ARG A CG  1 
ATOM   1522 C CD  . ARG B 2 191 ? 43.35233 -27.95259 20.35432  1.000 45.91606  ? 189 ARG A CD  1 
ATOM   1523 N NE  . ARG B 2 191 ? 43.88929 -26.71599 20.90731  1.000 60.21606  ? 189 ARG A NE  1 
ATOM   1524 C CZ  . ARG B 2 191 ? 44.14475 -25.62355 20.20249  1.000 74.40606  ? 189 ARG A CZ  1 
ATOM   1525 N NH1 . ARG B 2 191 ? 43.91825 -25.57369 18.89923  1.000 74.82606  ? 189 ARG A NH1 1 
ATOM   1526 N NH2 . ARG B 2 191 ? 44.63989 -24.55421 20.82210  1.000 82.15606  ? 189 ARG A NH2 1 
ATOM   1527 N N   . ALA B 2 192 ? 38.53528 -28.52765 19.77616  1.000 19.28796  ? 190 ALA A N   1 
ATOM   1528 C CA  . ALA B 2 192 ? 37.71498 -29.67919 19.42867  1.000 19.87796  ? 190 ALA A CA  1 
ATOM   1529 C C   . ALA B 2 192 ? 38.46210 -30.97443 19.75958  1.000 22.67796  ? 190 ALA A C   1 
ATOM   1530 O O   . ALA B 2 192 ? 39.69013 -31.03221 19.62216  1.000 21.45796  ? 190 ALA A O   1 
ATOM   1531 C CB  . ALA B 2 192 ? 37.35315 -29.62819 17.94273  1.000 19.38796  ? 190 ALA A CB  1 
ATOM   1532 N N   . PRO B 2 193 ? 37.76286 -32.02285 20.20834  1.000 22.07283  ? 191 PRO A N   1 
ATOM   1533 C CA  . PRO B 2 193 ? 38.47218 -33.24090 20.64385  1.000 25.53283  ? 191 PRO A CA  1 
ATOM   1534 C C   . PRO B 2 193 ? 39.25815 -33.92577 19.54605  1.000 27.68283  ? 191 PRO A C   1 
ATOM   1535 O O   . PRO B 2 193 ? 40.31843 -34.50057 19.83301  1.000 29.28283  ? 191 PRO A O   1 
ATOM   1536 C CB  . PRO B 2 193 ? 37.34132 -34.13740 21.16642  1.000 26.74283  ? 191 PRO A CB  1 
ATOM   1537 C CG  . PRO B 2 193 ? 36.11609 -33.60812 20.52061  1.000 26.61283  ? 191 PRO A CG  1 
ATOM   1538 C CD  . PRO B 2 193 ? 36.31330 -32.13293 20.41128  1.000 22.02283  ? 191 PRO A CD  1 
ATOM   1539 N N   . GLU B 2 194 ? 38.80459 -33.84069 18.29008  1.000 26.30311  ? 192 GLU A N   1 
ATOM   1540 C CA  . GLU B 2 194 ? 39.49231 -34.53965 17.21265  1.000 28.86311  ? 192 GLU A CA  1 
ATOM   1541 C C   . GLU B 2 194 ? 40.83669 -33.91274 16.86430  1.000 32.10311  ? 192 GLU A C   1 
ATOM   1542 O O   . GLU B 2 194 ? 41.66310 -34.57844 16.23390  1.000 37.20311  ? 192 GLU A O   1 
ATOM   1543 C CB  . GLU B 2 194 ? 38.61412 -34.59912 15.96566  1.000 29.52311  ? 192 GLU A CB  1 
ATOM   1544 C CG  . GLU B 2 194 ? 38.38875 -33.25305 15.30075  1.000 27.87311  ? 192 GLU A CG  1 
ATOM   1545 C CD  . GLU B 2 194 ? 37.10575 -32.56840 15.75142  1.000 26.01311  ? 192 GLU A CD  1 
ATOM   1546 O OE1 . GLU B 2 194 ? 36.59027 -32.89862 16.84767  1.000 23.66311  ? 192 GLU A OE1 1 
ATOM   1547 O OE2 . GLU B 2 194 ? 36.61199 -31.70158 14.99299  1.000 23.57311  ? 192 GLU A OE2 1 
ATOM   1548 N N   . ILE B 2 195 ? 41.08337 -32.65690 17.23856  1.000 29.42192  ? 193 ILE A N   1 
ATOM   1549 C CA  . ILE B 2 195 ? 42.40264 -32.07408 17.01020  1.000 33.22192  ? 193 ILE A CA  1 
ATOM   1550 C C   . ILE B 2 195 ? 43.23951 -32.02555 18.28656  1.000 28.76192  ? 193 ILE A C   1 
ATOM   1551 O O   . ILE B 2 195 ? 44.47646 -32.01787 18.20106  1.000 28.56192  ? 193 ILE A O   1 
ATOM   1552 C CB  . ILE B 2 195 ? 42.31301 -30.67224 16.36761  1.000 40.02192  ? 193 ILE A CB  1 
ATOM   1553 C CG1 . ILE B 2 195 ? 41.40566 -29.75370 17.17157  1.000 44.75192  ? 193 ILE A CG1 1 
ATOM   1554 C CG2 . ILE B 2 195 ? 41.81394 -30.76367 14.92709  1.000 43.26192  ? 193 ILE A CG2 1 
ATOM   1555 C CD1 . ILE B 2 195 ? 41.40392 -28.33936 16.65871  1.000 48.95192  ? 193 ILE A CD1 1 
ATOM   1556 N N   . MET B 2 196 ? 42.60864 -32.02939 19.45944  1.000 28.51210  ? 194 MET A N   1 
ATOM   1557 C CA  . MET B 2 196 ? 43.35616 -32.10709 20.70839  1.000 33.99210  ? 194 MET A CA  1 
ATOM   1558 C C   . MET B 2 196 ? 44.15222 -33.40473 20.81868  1.000 33.04210  ? 194 MET A C   1 
ATOM   1559 O O   . MET B 2 196 ? 45.25808 -33.40979 21.37420  1.000 27.54210  ? 194 MET A O   1 
ATOM   1560 C CB  . MET B 2 196 ? 42.40235 -31.97398 21.88564  1.000 33.16210  ? 194 MET A CB  1 
ATOM   1561 C CG  . MET B 2 196 ? 43.10844 -31.97847 23.19856  1.000 36.77210  ? 194 MET A CG  1 
ATOM   1562 S SD  . MET B 2 196 ? 41.98715 -31.94831 24.56350  1.000 43.59210  ? 194 MET A SD  1 
ATOM   1563 C CE  . MET B 2 196 ? 41.03041 -33.43959 24.27211  1.000 48.22210  ? 194 MET A CE  1 
ATOM   1564 N N   . LEU B 2 197 ? 43.62584 -34.50553 20.28436  1.000 28.46137  ? 195 LEU A N   1 
ATOM   1565 C CA  . LEU B 2 197 ? 44.31166 -35.79226 20.31770  1.000 34.81137  ? 195 LEU A CA  1 
ATOM   1566 C C   . LEU B 2 197 ? 44.76969 -36.24383 18.93903  1.000 31.72137  ? 195 LEU A C   1 
ATOM   1567 O O   . LEU B 2 197 ? 45.17950 -37.40065 18.78107  1.000 31.10137  ? 195 LEU A O   1 
ATOM   1568 C CB  . LEU B 2 197 ? 43.40836 -36.85572 20.94490  1.000 37.97137  ? 195 LEU A CB  1 
ATOM   1569 C CG  . LEU B 2 197 ? 42.98642 -36.52497 22.37482  1.000 38.61137  ? 195 LEU A CG  1 
ATOM   1570 C CD1 . LEU B 2 197 ? 41.62311 -37.11482 22.66552  1.000 41.39137  ? 195 LEU A CD1 1 
ATOM   1571 C CD2 . LEU B 2 197 ? 44.02133 -37.01769 23.37451  1.000 36.09137  ? 195 LEU A CD2 1 
ATOM   1572 N N   . ASN B 2 198 ? 44.69886 -35.35917 17.94431  1.000 33.31060  ? 196 ASN A N   1 
ATOM   1573 C CA  . ASN B 2 198 ? 45.14940 -35.63551 16.58147  1.000 35.04060  ? 196 ASN A CA  1 
ATOM   1574 C C   . ASN B 2 198 ? 44.42280 -36.84277 15.98743  1.000 29.99060  ? 196 ASN A C   1 
ATOM   1575 O O   . ASN B 2 198 ? 45.03059 -37.69066 15.33548  1.000 36.97060  ? 196 ASN A O   1 
ATOM   1576 C CB  . ASN B 2 198 ? 46.67364 -35.82072 16.53545  1.000 42.35060  ? 196 ASN A CB  1 
ATOM   1577 C CG  . ASN B 2 198 ? 47.24850 -35.59854 15.15473  1.000 47.17060  ? 196 ASN A CG  1 
ATOM   1578 O OD1 . ASN B 2 198 ? 46.84254 -34.67896 14.44585  1.000 58.29060  ? 196 ASN A OD1 1 
ATOM   1579 N ND2 . ASN B 2 198 ? 48.19388 -36.44845 14.75925  1.000 58.09060  ? 196 ASN A ND2 1 
ATOM   1580 N N   . TRP B 2 199 ? 43.10701 -36.93030 16.22490  1.000 30.19345  ? 197 TRP A N   1 
ATOM   1581 C CA  . TRP B 2 199 ? 42.33435 -38.05863 15.70322  1.000 28.57345  ? 197 TRP A CA  1 
ATOM   1582 C C   . TRP B 2 199 ? 42.24701 -38.02953 14.18919  1.000 28.61345  ? 197 TRP A C   1 
ATOM   1583 O O   . TRP B 2 199 ? 42.22351 -39.08604 13.55112  1.000 28.51345  ? 197 TRP A O   1 
ATOM   1584 C CB  . TRP B 2 199 ? 40.91755 -38.06752 16.27802  1.000 26.57345  ? 197 TRP A CB  1 
ATOM   1585 C CG  . TRP B 2 199 ? 40.80610 -38.49614 17.70388  1.000 28.38345  ? 197 TRP A CG  1 
ATOM   1586 C CD1 . TRP B 2 199 ? 41.76673 -39.08192 18.46852  1.000 30.84345  ? 197 TRP A CD1 1 
ATOM   1587 C CD2 . TRP B 2 199 ? 39.65127 -38.36719 18.53838  1.000 32.10345  ? 197 TRP A CD2 1 
ATOM   1588 N NE1 . TRP B 2 199 ? 41.28236 -39.32736 19.73258  1.000 34.02345  ? 197 TRP A NE1 1 
ATOM   1589 C CE2 . TRP B 2 199 ? 39.98554 -38.89220 19.80040  1.000 36.31345  ? 197 TRP A CE2 1 
ATOM   1590 C CE3 . TRP B 2 199 ? 38.36798 -37.85321 18.33943  1.000 35.31345  ? 197 TRP A CE3 1 
ATOM   1591 C CZ2 . TRP B 2 199 ? 39.07932 -38.92346 20.85973  1.000 38.19345  ? 197 TRP A CZ2 1 
ATOM   1592 C CZ3 . TRP B 2 199 ? 37.47227 -37.88588 19.38606  1.000 36.57345  ? 197 TRP A CZ3 1 
ATOM   1593 C CH2 . TRP B 2 199 ? 37.83042 -38.41836 20.63036  1.000 36.41345  ? 197 TRP A CH2 1 
ATOM   1594 N N   . MET B 2 200 ? 42.18545 -36.84013 13.60224  1.000 33.92025  ? 198 MET A N   1 
ATOM   1595 C CA  . MET B 2 200 ? 42.01043 -36.69440 12.16465  1.000 37.22025  ? 198 MET A CA  1 
ATOM   1596 C C   . MET B 2 200 ? 42.40390 -35.27571 11.77219  1.000 39.51025  ? 198 MET A C   1 
ATOM   1597 O O   . MET B 2 200 ? 42.84483 -34.47572 12.60374  1.000 33.50025  ? 198 MET A O   1 
ATOM   1598 C CB  . MET B 2 200 ? 40.57149 -37.01531 11.75576  1.000 40.27025  ? 198 MET A CB  1 
ATOM   1599 C CG  . MET B 2 200 ? 39.56107 -36.28283 12.59620  1.000 42.50025  ? 198 MET A CG  1 
ATOM   1600 S SD  . MET B 2 200 ? 37.89775 -36.83810 12.24973  1.000 43.84025  ? 198 MET A SD  1 
ATOM   1601 C CE  . MET B 2 200 ? 37.59808 -37.89896 13.65015  1.000 44.12025  ? 198 MET A CE  1 
ATOM   1602 N N   . HIS B 2 201 ? 42.22192 -34.96840 10.49036  1.000 42.08205  ? 199 HIS A N   1 
ATOM   1603 C CA  . HIS B 2 201 ? 42.71907 -33.72093 9.93443   1.000 55.74205  ? 199 HIS A CA  1 
ATOM   1604 C C   . HIS B 2 201 ? 41.87858 -32.52697 10.38271  1.000 51.14205  ? 199 HIS A C   1 
ATOM   1605 O O   . HIS B 2 201 ? 40.68437 -32.64839 10.67918  1.000 47.29205  ? 199 HIS A O   1 
ATOM   1606 C CB  . HIS B 2 201 ? 42.75327 -33.80091 8.40686   1.000 68.64205  ? 199 HIS A CB  1 
ATOM   1607 C CG  . HIS B 2 201 ? 43.95514 -34.51540 7.86859   1.000 83.71205  ? 199 HIS A CG  1 
ATOM   1608 N ND1 . HIS B 2 201 ? 45.24364 -34.07401 8.08692   1.000 87.51205  ? 199 HIS A ND1 1 
ATOM   1609 C CD2 . HIS B 2 201 ? 44.06546 -35.63917 7.12101   1.000 89.76205  ? 199 HIS A CD2 1 
ATOM   1610 C CE1 . HIS B 2 201 ? 46.09519 -34.89546 7.49845   1.000 85.38205  ? 199 HIS A CE1 1 
ATOM   1611 N NE2 . HIS B 2 201 ? 45.40612 -35.85326 6.90432   1.000 86.15205  ? 199 HIS A NE2 1 
ATOM   1612 N N   . TYR B 2 202 ? 42.54098 -31.36721 10.45503  1.000 52.47546  ? 200 TYR A N   1 
ATOM   1613 C CA  . TYR B 2 202 ? 41.87370 -30.09649 10.71382  1.000 51.74546  ? 200 TYR A CA  1 
ATOM   1614 C C   . TYR B 2 202 ? 40.77302 -29.85541 9.69272   1.000 45.59546  ? 200 TYR A C   1 
ATOM   1615 O O   . TYR B 2 202 ? 40.98869 -29.96889 8.48285   1.000 41.53546  ? 200 TYR A O   1 
ATOM   1616 C CB  . TYR B 2 202 ? 42.88222 -28.94557 10.65671  1.000 51.93546  ? 200 TYR A CB  1 
ATOM   1617 C CG  . TYR B 2 202 ? 43.56332 -28.61113 11.96122  1.000 56.32546  ? 200 TYR A CG  1 
ATOM   1618 C CD1 . TYR B 2 202 ? 44.76488 -29.20664 12.31658  1.000 60.12546  ? 200 TYR A CD1 1 
ATOM   1619 C CD2 . TYR B 2 202 ? 43.01522 -27.67519 12.82696  1.000 63.70546  ? 200 TYR A CD2 1 
ATOM   1620 C CE1 . TYR B 2 202 ? 45.39698 -28.88655 13.51259  1.000 66.21546  ? 200 TYR A CE1 1 
ATOM   1621 C CE2 . TYR B 2 202 ? 43.63493 -27.34816 14.02214  1.000 67.76546  ? 200 TYR A CE2 1 
ATOM   1622 C CZ  . TYR B 2 202 ? 44.82307 -27.95447 14.36198  1.000 68.96546  ? 200 TYR A CZ  1 
ATOM   1623 O OH  . TYR B 2 202 ? 45.42920 -27.61905 15.55466  1.000 64.86546  ? 200 TYR A OH  1 
ATOM   1624 N N   . ASN B 2 203 ? 39.58596 -29.55292 10.19281  1.000 45.35169  ? 201 ASN A N   1 
ATOM   1625 C CA  . ASN B 2 203 ? 38.46418 -29.15818 9.36684   1.000 40.66169  ? 201 ASN A CA  1 
ATOM   1626 C C   . ASN B 2 203 ? 37.90859 -27.85475 9.92206   1.000 27.88169  ? 201 ASN A C   1 
ATOM   1627 O O   . ASN B 2 203 ? 38.10102 -27.54482 11.09612  1.000 22.90169  ? 201 ASN A O   1 
ATOM   1628 C CB  . ASN B 2 203 ? 37.39684 -30.24622 9.34843   1.000 43.03169  ? 201 ASN A CB  1 
ATOM   1629 C CG  . ASN B 2 203 ? 36.40205 -30.04022 8.25587   1.000 45.31169  ? 201 ASN A CG  1 
ATOM   1630 O OD1 . ASN B 2 203 ? 35.20992 -29.98879 8.50472   1.000 54.15169  ? 201 ASN A OD1 1 
ATOM   1631 N ND2 . ASN B 2 203 ? 36.88709 -29.89715 7.02603   1.000 48.47169  ? 201 ASN A ND2 1 
ATOM   1632 N N   . GLN B 2 204 ? 37.21791 -27.08032 9.07510   1.000 27.23173  ? 202 GLN A N   1 
ATOM   1633 C CA  . GLN B 2 204 ? 36.68177 -25.80271 9.53967   1.000 21.94173  ? 202 GLN A CA  1 
ATOM   1634 C C   . GLN B 2 204 ? 35.64811 -25.97849 10.65220  1.000 19.20173  ? 202 GLN A C   1 
ATOM   1635 O O   . GLN B 2 204 ? 35.45909 -25.06278 11.46117  1.000 12.10173  ? 202 GLN A O   1 
ATOM   1636 C CB  . GLN B 2 204 ? 36.10766 -25.01339 8.36053   1.000 21.31173  ? 202 GLN A CB  1 
ATOM   1637 C CG  . GLN B 2 204 ? 34.97791 -25.66874 7.64496   1.000 23.44173  ? 202 GLN A CG  1 
ATOM   1638 C CD  . GLN B 2 204 ? 34.52483 -24.86215 6.43838   1.000 24.41173  ? 202 GLN A CD  1 
ATOM   1639 O OE1 . GLN B 2 204 ? 33.32510 -24.65729 6.23599   1.000 26.87173  ? 202 GLN A OE1 1 
ATOM   1640 N NE2 . GLN B 2 204 ? 35.47896 -24.39446 5.63989   1.000 19.14173  ? 202 GLN A NE2 1 
ATOM   1641 N N   . THR B 2 205 ? 35.04585 -27.16960 10.75668  1.000 17.28669  ? 203 THR A N   1 
ATOM   1642 C CA  . THR B 2 205 ? 34.14619 -27.52936 11.84826  1.000 20.37669  ? 203 THR A CA  1 
ATOM   1643 C C   . THR B 2 205 ? 34.78501 -27.43223 13.23044  1.000 15.63669  ? 203 THR A C   1 
ATOM   1644 O O   . THR B 2 205 ? 34.05445 -27.42054 14.23302  1.000 12.81669  ? 203 THR A O   1 
ATOM   1645 C CB  . THR B 2 205 ? 33.66176 -28.96076 11.62544  1.000 28.41669  ? 203 THR A CB  1 
ATOM   1646 O OG1 . THR B 2 205 ? 34.80595 -29.81092 11.46034  1.000 32.26669  ? 203 THR A OG1 1 
ATOM   1647 C CG2 . THR B 2 205 ? 32.88472 -29.02594 10.35045  1.000 34.01669  ? 203 THR A CG2 1 
ATOM   1648 N N   . VAL B 2 206 ? 36.12065 -27.39420 13.32380  1.000 15.02355  ? 204 VAL A N   1 
ATOM   1649 C CA  . VAL B 2 206 ? 36.72069 -27.26795 14.65000  1.000 15.51355  ? 204 VAL A CA  1 
ATOM   1650 C C   . VAL B 2 206 ? 36.46334 -25.88756 15.22375  1.000 11.60355  ? 204 VAL A C   1 
ATOM   1651 O O   . VAL B 2 206 ? 36.38128 -25.73987 16.44756  1.000 12.38355  ? 204 VAL A O   1 
ATOM   1652 C CB  . VAL B 2 206 ? 38.23332 -27.60053 14.65515  1.000 17.03355  ? 204 VAL A CB  1 
ATOM   1653 C CG1 . VAL B 2 206 ? 38.49185 -28.96225 14.05413  1.000 19.29355  ? 204 VAL A CG1 1 
ATOM   1654 C CG2 . VAL B 2 206 ? 39.07099 -26.51155 13.98900  1.000 17.44355  ? 204 VAL A CG2 1 
ATOM   1655 N N   . ASP B 2 207 ? 36.33070 -24.85815 14.36678  1.000 10.52417  ? 205 ASP A N   1 
ATOM   1656 C CA  . ASP B 2 207 ? 36.00067 -23.51828 14.85322  1.000 10.31417  ? 205 ASP A CA  1 
ATOM   1657 C C   . ASP B 2 207 ? 34.58670 -23.46070 15.43027  1.000 9.55417   ? 205 ASP A C   1 
ATOM   1658 O O   . ASP B 2 207 ? 34.33383 -22.67729 16.34383  1.000 10.25417  ? 205 ASP A O   1 
ATOM   1659 C CB  . ASP B 2 207 ? 36.14844 -22.46203 13.73799  1.000 9.58417   ? 205 ASP A CB  1 
ATOM   1660 C CG  . ASP B 2 207 ? 37.60479 -22.26235 13.27326  1.000 11.19417  ? 205 ASP A CG  1 
ATOM   1661 O OD1 . ASP B 2 207 ? 38.53978 -22.47306 14.07362  1.000 10.45417  ? 205 ASP A OD1 1 
ATOM   1662 O OD2 . ASP B 2 207 ? 37.81211 -21.86445 12.10556  1.000 11.12417  ? 205 ASP A OD2 1 
ATOM   1663 N N   . ILE B 2 208 ? 33.65599 -24.26399 14.90518  1.000 10.11260  ? 206 ILE A N   1 
ATOM   1664 C CA  . ILE B 2 208 ? 32.28171 -24.26682 15.42047  1.000 9.63260   ? 206 ILE A CA  1 
ATOM   1665 C C   . ILE B 2 208 ? 32.23457 -24.85170 16.83605  1.000 8.26260   ? 206 ILE A C   1 
ATOM   1666 O O   . ILE B 2 208 ? 31.50283 -24.35698 17.70303  1.000 8.20260   ? 206 ILE A O   1 
ATOM   1667 C CB  . ILE B 2 208 ? 31.36032 -25.03988 14.45009  1.000 10.75260  ? 206 ILE A CB  1 
ATOM   1668 C CG1 . ILE B 2 208 ? 31.23716 -24.30690 13.11058  1.000 12.27260  ? 206 ILE A CG1 1 
ATOM   1669 C CG2 . ILE B 2 208 ? 29.94921 -25.25595 15.05898  1.000 12.08260  ? 206 ILE A CG2 1 
ATOM   1670 C CD1 . ILE B 2 208 ? 30.59936 -22.90259 13.23515  1.000 12.00260  ? 206 ILE A CD1 1 
ATOM   1671 N N   . TRP B 2 209 ? 33.00114 -25.91896 17.08285  1.000 10.07543  ? 207 TRP A N   1 
ATOM   1672 C CA  . TRP B 2 209 ? 33.15077 -26.45436 18.43546  1.000 9.71543   ? 207 TRP A CA  1 
ATOM   1673 C C   . TRP B 2 209 ? 33.58449 -25.36677 19.41293  1.000 8.68543   ? 207 TRP A C   1 
ATOM   1674 O O   . TRP B 2 209 ? 32.98806 -25.20411 20.48288  1.000 8.58543   ? 207 TRP A O   1 
ATOM   1675 C CB  . TRP B 2 209 ? 34.17031 -27.60491 18.44338  1.000 9.98543   ? 207 TRP A CB  1 
ATOM   1676 C CG  . TRP B 2 209 ? 34.33918 -28.20281 19.83339  1.000 11.81543  ? 207 TRP A CG  1 
ATOM   1677 C CD1 . TRP B 2 209 ? 35.17132 -27.76902 20.82922  1.000 12.48543  ? 207 TRP A CD1 1 
ATOM   1678 C CD2 . TRP B 2 209 ? 33.61308 -29.30731 20.37427  1.000 13.12543  ? 207 TRP A CD2 1 
ATOM   1679 N NE1 . TRP B 2 209 ? 35.01294 -28.54395 21.95365  1.000 13.69543  ? 207 TRP A NE1 1 
ATOM   1680 C CE2 . TRP B 2 209 ? 34.07181 -29.50643 21.69419  1.000 13.39543  ? 207 TRP A CE2 1 
ATOM   1681 C CE3 . TRP B 2 209 ? 32.62960 -30.16803 19.86102  1.000 14.37543  ? 207 TRP A CE3 1 
ATOM   1682 C CZ2 . TRP B 2 209 ? 33.56753 -30.52116 22.51690  1.000 13.14543  ? 207 TRP A CZ2 1 
ATOM   1683 C CZ3 . TRP B 2 209 ? 32.14069 -31.18493 20.67752  1.000 13.88543  ? 207 TRP A CZ3 1 
ATOM   1684 C CH2 . TRP B 2 209 ? 32.61022 -31.35018 21.98693  1.000 13.83543  ? 207 TRP A CH2 1 
ATOM   1685 N N   . SER B 2 210 ? 34.60137 -24.57752 19.03258  1.000 10.05128  ? 208 SER A N   1 
ATOM   1686 C CA  . SER B 2 210 ? 35.08075 -23.51086 19.91102  1.000 9.49128   ? 208 SER A CA  1 
ATOM   1687 C C   . SER B 2 210 ? 33.99546 -22.48459 20.19036  1.000 8.32128   ? 208 SER A C   1 
ATOM   1688 O O   . SER B 2 210 ? 33.86363 -22.02173 21.32620  1.000 9.63128   ? 208 SER A O   1 
ATOM   1689 C CB  . SER B 2 210 ? 36.30908 -22.82464 19.30821  1.000 9.44128   ? 208 SER A CB  1 
ATOM   1690 O OG  . SER B 2 210 ? 37.30829 -23.75631 18.94342  1.000 11.02128  ? 208 SER A OG  1 
ATOM   1691 N N   . VAL B 2 211 ? 33.19121 -22.13423 19.17745  1.000 7.43829   ? 209 VAL A N   1 
ATOM   1692 C CA  . VAL B 2 211 ? 32.08537 -21.20133 19.39636  1.000 8.15829   ? 209 VAL A CA  1 
ATOM   1693 C C   . VAL B 2 211 ? 31.10499 -21.77187 20.40252  1.000 7.53829   ? 209 VAL A C   1 
ATOM   1694 O O   . VAL B 2 211 ? 30.60930 -21.05101 21.27056  1.000 8.04829   ? 209 VAL A O   1 
ATOM   1695 C CB  . VAL B 2 211 ? 31.37336 -20.85329 18.07186  1.000 9.26829   ? 209 VAL A CB  1 
ATOM   1696 C CG1 . VAL B 2 211 ? 30.13335 -19.97433 18.32114  1.000 9.57829   ? 209 VAL A CG1 1 
ATOM   1697 C CG2 . VAL B 2 211 ? 32.33091 -20.14123 17.15552  1.000 10.50829  ? 209 VAL A CG2 1 
ATOM   1698 N N   . GLY B 2 212 ? 30.82014 -23.07700 20.30825  1.000 8.77548   ? 210 GLY A N   1 
ATOM   1699 C CA  . GLY B 2 212 ? 29.91452 -23.69654 21.26699  1.000 9.11548   ? 210 GLY A CA  1 
ATOM   1700 C C   . GLY B 2 212 ? 30.43034 -23.58249 22.69277  1.000 8.51548   ? 210 GLY A C   1 
ATOM   1701 O O   . GLY B 2 212 ? 29.68662 -23.20640 23.60220  1.000 7.99548   ? 210 GLY A O   1 
ATOM   1702 N N   . CYS B 2 213 ? 31.73134 -23.84202 22.88531  1.000 8.37169   ? 211 CYS A N   1 
ATOM   1703 C CA  . CYS B 2 213 ? 32.34569 -23.72279 24.20897  1.000 9.24169   ? 211 CYS A CA  1 
ATOM   1704 C C   . CYS B 2 213 ? 32.28843 -22.29432 24.72068  1.000 8.18169   ? 211 CYS A C   1 
ATOM   1705 O O   . CYS B 2 213 ? 32.02666 -22.06135 25.91040  1.000 8.09169   ? 211 CYS A O   1 
ATOM   1706 C CB  . CYS B 2 213 ? 33.79966 -24.18923 24.15767  1.000 10.22169  ? 211 CYS A CB  1 
ATOM   1707 S SG  . CYS B 2 213 ? 33.95869 -25.90690 23.73504  1.000 14.29169  ? 211 CYS A SG  1 
ATOM   1708 N N   . ILE B 2 214 ? 32.51240 -21.32507 23.82673  1.000 8.05257   ? 212 ILE A N   1 
ATOM   1709 C CA  . ILE B 2 214 ? 32.48540 -19.91330 24.20063  1.000 7.96257   ? 212 ILE A CA  1 
ATOM   1710 C C   . ILE B 2 214 ? 31.07968 -19.48834 24.59592  1.000 8.18257   ? 212 ILE A C   1 
ATOM   1711 O O   . ILE B 2 214 ? 30.87652 -18.79889 25.60578  1.000 8.17257   ? 212 ILE A O   1 
ATOM   1712 C CB  . ILE B 2 214 ? 33.02259 -19.05671 23.03383  1.000 9.91257   ? 212 ILE A CB  1 
ATOM   1713 C CG1 . ILE B 2 214 ? 34.52555 -19.29645 22.82872  1.000 11.35257  ? 212 ILE A CG1 1 
ATOM   1714 C CG2 . ILE B 2 214 ? 32.73273 -17.60377 23.27665  1.000 10.20257  ? 212 ILE A CG2 1 
ATOM   1715 C CD1 . ILE B 2 214 ? 35.05565 -18.84605 21.46849  1.000 12.18257  ? 212 ILE A CD1 1 
ATOM   1716 N N   . MET B 2 215 ? 30.08821 -19.87732 23.78546  1.000 8.20190   ? 213 MET A N   1 
ATOM   1717 C CA  . MET B 2 215 ? 28.70671 -19.50351 24.04835  1.000 8.75190   ? 213 MET A CA  1 
ATOM   1718 C C   . MET B 2 215 ? 28.19028 -20.07512 25.36376  1.000 8.36190   ? 213 MET A C   1 
ATOM   1719 O O   . MET B 2 215 ? 27.47698 -19.38410 26.09931  1.000 8.55190   ? 213 MET A O   1 
ATOM   1720 C CB  . MET B 2 215 ? 27.82546 -19.97826 22.89778  1.000 9.42190   ? 213 MET A CB  1 
ATOM   1721 C CG  . MET B 2 215 ? 26.37152 -19.66142 23.10390  1.000 11.81190  ? 213 MET A CG  1 
ATOM   1722 S SD  . MET B 2 215 ? 25.43350 -20.04063 21.61670  1.000 11.86190  ? 213 MET A SD  1 
ATOM   1723 C CE  . MET B 2 215 ? 23.79919 -19.85823 22.23900  1.000 14.27190  ? 213 MET A CE  1 
ATOM   1724 N N   . ALA B 2 216 ? 28.48411 -21.34899 25.64187  1.000 9.76082   ? 214 ALA A N   1 
ATOM   1725 C CA  . ALA B 2 216 ? 28.10138 -21.94413 26.92062  1.000 10.82082  ? 214 ALA A CA  1 
ATOM   1726 C C   . ALA B 2 216 ? 28.66920 -21.14147 28.08809  1.000 11.59082  ? 214 ALA A C   1 
ATOM   1727 O O   . ALA B 2 216 ? 27.95112 -20.82217 29.03560  1.000 11.16082  ? 214 ALA A O   1 
ATOM   1728 C CB  . ALA B 2 216 ? 28.58386 -23.39751 26.98210  1.000 11.12082  ? 214 ALA A CB  1 
ATOM   1729 N N   . GLU B 2 217 ? 29.93224 -20.73286 27.98130  1.000 11.60401  ? 215 GLU A N   1 
ATOM   1730 C CA  . GLU B 2 217 ? 30.57696 -19.95541 29.03807  1.000 14.25401  ? 215 GLU A CA  1 
ATOM   1731 C C   . GLU B 2 217 ? 29.94943 -18.56849 29.19647  1.000 12.98401  ? 215 GLU A C   1 
ATOM   1732 O O   . GLU B 2 217 ? 29.76843 -18.08713 30.32386  1.000 12.14401  ? 215 GLU A O   1 
ATOM   1733 C CB  . GLU B 2 217 ? 32.07087 -19.85832 28.73164  1.000 17.12401  ? 215 GLU A CB  1 
ATOM   1734 C CG  . GLU B 2 217 ? 32.86009 -18.97545 29.68172  1.000 23.25401  ? 215 GLU A CG  1 
ATOM   1735 C CD  . GLU B 2 217 ? 34.33743 -19.30627 29.66650  1.000 23.92401  ? 215 GLU A CD  1 
ATOM   1736 O OE1 . GLU B 2 217 ? 34.79191 -20.00348 28.73298  1.000 23.22401  ? 215 GLU A OE1 1 
ATOM   1737 O OE2 . GLU B 2 217 ? 35.03875 -18.88686 30.60965  1.000 37.30401  ? 215 GLU A OE2 1 
ATOM   1738 N N   . LEU B 2 218 ? 29.58092 -17.92136 28.08434  1.000 13.78469  ? 216 LEU A N   1 
ATOM   1739 C CA  . LEU B 2 218 ? 28.89874 -16.63023 28.16464  1.000 12.11469  ? 216 LEU A CA  1 
ATOM   1740 C C   . LEU B 2 218 ? 27.52296 -16.74731 28.81515  1.000 12.80469  ? 216 LEU A C   1 
ATOM   1741 O O   . LEU B 2 218 ? 27.08201 -15.81191 29.48524  1.000 16.51469  ? 216 LEU A O   1 
ATOM   1742 C CB  . LEU B 2 218 ? 28.74828 -16.01408 26.76584  1.000 11.63469  ? 216 LEU A CB  1 
ATOM   1743 C CG  . LEU B 2 218 ? 30.03535 -15.63352 26.04083  1.000 12.85469  ? 216 LEU A CG  1 
ATOM   1744 C CD1 . LEU B 2 218 ? 29.71185 -14.83466 24.77402  1.000 13.15469  ? 216 LEU A CD1 1 
ATOM   1745 C CD2 . LEU B 2 218 ? 30.95614 -14.85490 26.97327  1.000 16.28469  ? 216 LEU A CD2 1 
ATOM   1746 N N   . LEU B 2 219 ? 26.82381 -17.86393 28.60386  1.000 12.95578  ? 217 LEU A N   1 
ATOM   1747 C CA  . LEU B 2 219 ? 25.47889 -18.04472 29.14527  1.000 13.47578  ? 217 LEU A CA  1 
ATOM   1748 C C   . LEU B 2 219 ? 25.49666 -18.37685 30.63485  1.000 16.32578  ? 217 LEU A C   1 
ATOM   1749 O O   . LEU B 2 219 ? 24.61474 -17.93616 31.37882  1.000 19.94578  ? 217 LEU A O   1 
ATOM   1750 C CB  . LEU B 2 219 ? 24.75602 -19.16160 28.39722  1.000 13.63578  ? 217 LEU A CB  1 
ATOM   1751 C CG  . LEU B 2 219 ? 24.37767 -18.85353 26.94349  1.000 15.88578  ? 217 LEU A CG  1 
ATOM   1752 C CD1 . LEU B 2 219 ? 23.85263 -20.10058 26.25926  1.000 16.32578  ? 217 LEU A CD1 1 
ATOM   1753 C CD2 . LEU B 2 219 ? 23.37586 -17.71793 26.89096  1.000 16.64578  ? 217 LEU A CD2 1 
ATOM   1754 N N   . THR B 2 220 ? 26.46021 -19.18005 31.07480  1.000 17.31525  ? 218 THR A N   1 
ATOM   1755 C CA  . THR B 2 220 ? 26.45242 -19.69268 32.44166  1.000 20.32525  ? 218 THR A CA  1 
ATOM   1756 C C   . THR B 2 220 ? 27.41410 -18.96629 33.36697  1.000 25.10525  ? 218 THR A C   1 
ATOM   1757 O O   . THR B 2 220 ? 27.17739 -18.93386 34.58117  1.000 26.44525  ? 218 THR A O   1 
ATOM   1758 C CB  . THR B 2 220 ? 26.79766 -21.18401 32.45231  1.000 19.16525  ? 218 THR A CB  1 
ATOM   1759 O OG1 . THR B 2 220 ? 28.14713 -21.35708 32.00407  1.000 19.67525  ? 218 THR A OG1 1 
ATOM   1760 C CG2 . THR B 2 220 ? 25.85585 -21.96336 31.52097  1.000 20.52525  ? 218 THR A CG2 1 
ATOM   1761 N N   . GLY B 2 221 ? 28.47374 -18.36885 32.82653  1.000 21.67440  ? 219 GLY A N   1 
ATOM   1762 C CA  . GLY B 2 221 ? 29.54822 -17.83810 33.63212  1.000 25.76440  ? 219 GLY A CA  1 
ATOM   1763 C C   . GLY B 2 221 ? 30.59351 -18.85538 34.04634  1.000 27.38440  ? 219 GLY A C   1 
ATOM   1764 O O   . GLY B 2 221 ? 31.54322 -18.49431 34.76373  1.000 24.67440  ? 219 GLY A O   1 
ATOM   1765 N N   . ARG B 2 222 ? 30.45640 -20.10938 33.62243  1.000 22.48859  ? 220 ARG A N   1 
ATOM   1766 C CA  . ARG B 2 222 ? 31.40076 -21.17020 33.94408  1.000 22.88859  ? 220 ARG A CA  1 
ATOM   1767 C C   . ARG B 2 222 ? 32.02294 -21.69263 32.66044  1.000 21.16859  ? 220 ARG A C   1 
ATOM   1768 O O   . ARG B 2 222 ? 31.32402 -21.85999 31.65969  1.000 20.41859  ? 220 ARG A O   1 
ATOM   1769 C CB  . ARG B 2 222 ? 30.70973 -22.33385 34.68056  1.000 24.19859  ? 220 ARG A CB  1 
ATOM   1770 C CG  . ARG B 2 222 ? 29.63471 -21.91369 35.66958  1.000 25.40859  ? 220 ARG A CG  1 
ATOM   1771 C CD  . ARG B 2 222 ? 29.00150 -23.12508 36.31170  1.000 28.76859  ? 220 ARG A CD  1 
ATOM   1772 N NE  . ARG B 2 222 ? 27.59417 -22.89021 36.58509  1.000 33.23859  ? 220 ARG A NE  1 
ATOM   1773 C CZ  . ARG B 2 222 ? 26.59596 -23.29756 35.80762  1.000 30.41859  ? 220 ARG A CZ  1 
ATOM   1774 N NH1 . ARG B 2 222 ? 26.80966 -24.02879 34.72372  1.000 26.87859  ? 220 ARG A NH1 1 
ATOM   1775 N NH2 . ARG B 2 222 ? 25.34984 -22.95652 36.12348  1.000 33.25859  ? 220 ARG A NH2 1 
ATOM   1776 N N   . THR B 2 223 ? 33.33633 -21.93961 32.68441  1.000 19.25341  ? 221 THR A N   1 
ATOM   1777 C CA  . THR B 2 223 ? 33.97845 -22.66711 31.59847  1.000 20.96341  ? 221 THR A CA  1 
ATOM   1778 C C   . THR B 2 223 ? 33.31946 -24.03502 31.44108  1.000 22.64341  ? 221 THR A C   1 
ATOM   1779 O O   . THR B 2 223 ? 32.97892 -24.69312 32.42809  1.000 16.78341  ? 221 THR A O   1 
ATOM   1780 C CB  . THR B 2 223 ? 35.48013 -22.82757 31.87381  1.000 21.59341  ? 221 THR A CB  1 
ATOM   1781 O OG1 . THR B 2 223 ? 36.08684 -21.53596 32.00166  1.000 26.87341  ? 221 THR A OG1 1 
ATOM   1782 C CG2 . THR B 2 223 ? 36.16922 -23.57843 30.75974  1.000 20.55341  ? 221 THR A CG2 1 
ATOM   1783 N N   . LEU B 2 224 ? 33.09747 -24.44547 30.18760  1.000 18.48053  ? 222 LEU A N   1 
ATOM   1784 C CA  . LEU B 2 224 ? 32.32431 -25.65626 29.94519  1.000 17.08053  ? 222 LEU A CA  1 
ATOM   1785 C C   . LEU B 2 224 ? 33.15299 -26.91244 30.19312  1.000 17.56053  ? 222 LEU A C   1 
ATOM   1786 O O   . LEU B 2 224 ? 32.69121 -27.83511 30.87901  1.000 16.55053  ? 222 LEU A O   1 
ATOM   1787 C CB  . LEU B 2 224 ? 31.76771 -25.65001 28.52264  1.000 14.84053  ? 222 LEU A CB  1 
ATOM   1788 C CG  . LEU B 2 224 ? 30.87179 -26.83790 28.17194  1.000 15.03053  ? 222 LEU A CG  1 
ATOM   1789 C CD1 . LEU B 2 224 ? 29.67650 -26.90732 29.11199  1.000 14.34053  ? 222 LEU A CD1 1 
ATOM   1790 C CD2 . LEU B 2 224 ? 30.42108 -26.71553 26.71451  1.000 14.76053  ? 222 LEU A CD2 1 
ATOM   1791 N N   . PHE B 2 225 ? 34.36497 -26.97234 29.63619  1.000 15.37733  ? 223 PHE A N   1 
ATOM   1792 C CA  . PHE B 2 225 ? 35.25492 -28.13203 29.75570  1.000 17.42733  ? 223 PHE A CA  1 
ATOM   1793 C C   . PHE B 2 225 ? 36.61276 -27.71577 30.32102  1.000 17.13733  ? 223 PHE A C   1 
ATOM   1794 O O   . PHE B 2 225 ? 37.62090 -27.75929 29.61176  1.000 17.77733  ? 223 PHE A O   1 
ATOM   1795 C CB  . PHE B 2 225 ? 35.47052 -28.81808 28.40603  1.000 16.82733  ? 223 PHE A CB  1 
ATOM   1796 C CG  . PHE B 2 225 ? 34.20255 -29.20013 27.67608  1.000 18.82733  ? 223 PHE A CG  1 
ATOM   1797 C CD1 . PHE B 2 225 ? 33.26811 -30.05862 28.25253  1.000 21.00733  ? 223 PHE A CD1 1 
ATOM   1798 C CD2 . PHE B 2 225 ? 33.97546 -28.74335 26.38725  1.000 17.46733  ? 223 PHE A CD2 1 
ATOM   1799 C CE1 . PHE B 2 225 ? 32.11057 -30.43223 27.55520  1.000 19.41733  ? 223 PHE A CE1 1 
ATOM   1800 C CE2 . PHE B 2 225 ? 32.82496 -29.12418 25.68083  1.000 17.35733  ? 223 PHE A CE2 1 
ATOM   1801 C CZ  . PHE B 2 225 ? 31.89821 -29.96055 26.26803  1.000 17.02733  ? 223 PHE A CZ  1 
ATOM   1802 N N   . PRO B 2 226 ? 36.69089 -27.35145 31.60929  1.000 18.55110  ? 224 PRO A N   1 
ATOM   1803 C CA  . PRO B 2 226 ? 38.00430 -26.87368 32.12324  1.000 21.86110  ? 224 PRO A CA  1 
ATOM   1804 C C   . PRO B 2 226 ? 38.92843 -27.99144 32.60709  1.000 22.71110  ? 224 PRO A C   1 
ATOM   1805 O O   . PRO B 2 226 ? 39.25388 -28.11151 33.79262  1.000 24.16110  ? 224 PRO A O   1 
ATOM   1806 C CB  . PRO B 2 226 ? 37.58171 -25.93745 33.25273  1.000 21.96110  ? 224 PRO A CB  1 
ATOM   1807 C CG  . PRO B 2 226 ? 36.32646 -26.57095 33.79384  1.000 21.93110  ? 224 PRO A CG  1 
ATOM   1808 C CD  . PRO B 2 226 ? 35.63934 -27.26405 32.63709  1.000 20.35110  ? 224 PRO A CD  1 
ATOM   1809 N N   . GLY B 2 227 ? 39.38121 -28.83318 31.67271  1.000 21.12873  ? 225 GLY A N   1 
ATOM   1810 C CA  . GLY B 2 227 ? 40.24108 -29.94678 32.02588  1.000 26.25873  ? 225 GLY A CA  1 
ATOM   1811 C C   . GLY B 2 227 ? 41.68534 -29.52315 32.27569  1.000 31.10873  ? 225 GLY A C   1 
ATOM   1812 O O   . GLY B 2 227 ? 42.10576 -28.42510 31.92509  1.000 26.54873  ? 225 GLY A O   1 
ATOM   1813 N N   . THR B 2 228 ? 42.45190 -30.40811 32.91665  1.000 29.13696  ? 226 THR A N   1 
ATOM   1814 C CA  . THR B 2 228 ? 43.83050 -30.09311 33.28403  1.000 27.85696  ? 226 THR A CA  1 
ATOM   1815 C C   . THR B 2 228 ? 44.86366 -30.72820 32.36775  1.000 28.98696  ? 226 THR A C   1 
ATOM   1816 O O   . THR B 2 228 ? 45.94407 -30.16069 32.19643  1.000 40.47696  ? 226 THR A O   1 
ATOM   1817 C CB  . THR B 2 228 ? 44.12169 -30.52823 34.72145  1.000 28.22696  ? 226 THR A CB  1 
ATOM   1818 O OG1 . THR B 2 228 ? 43.72392 -31.89081 34.89049  1.000 33.48696  ? 226 THR A OG1 1 
ATOM   1819 C CG2 . THR B 2 228 ? 43.37388 -29.65298 35.70609  1.000 30.26696  ? 226 THR A CG2 1 
ATOM   1820 N N   . ASP B 2 229 ? 44.58818 -31.89800 31.79212  1.000 30.12848  ? 227 ASP A N   1 
ATOM   1821 C CA  . ASP B 2 229 ? 45.41303 -32.42644 30.71364  1.000 27.11848  ? 227 ASP A CA  1 
ATOM   1822 C C   . ASP B 2 229 ? 44.48840 -32.95967 29.63243  1.000 23.27848  ? 227 ASP A C   1 
ATOM   1823 O O   . ASP B 2 229 ? 43.26284 -32.85839 29.73660  1.000 25.97848  ? 227 ASP A O   1 
ATOM   1824 C CB  . ASP B 2 229 ? 46.41173 -33.48937 31.20815  1.000 32.22848  ? 227 ASP A CB  1 
ATOM   1825 C CG  . ASP B 2 229 ? 45.74203 -34.69760 31.87176  1.000 34.14848  ? 227 ASP A CG  1 
ATOM   1826 O OD1 . ASP B 2 229 ? 44.95443 -35.41434 31.21710  1.000 33.42848  ? 227 ASP A OD1 1 
ATOM   1827 O OD2 . ASP B 2 229 ? 46.04959 -34.96414 33.04871  1.000 34.99848  ? 227 ASP A OD2 1 
ATOM   1828 N N   . HIS B 2 230 ? 45.08921 -33.56177 28.60452  1.000 22.73344  ? 228 HIS A N   1 
ATOM   1829 C CA  . HIS B 2 230 ? 44.33023 -33.99009 27.43620  1.000 25.22344  ? 228 HIS A CA  1 
ATOM   1830 C C   . HIS B 2 230 ? 43.32018 -35.07696 27.78514  1.000 25.06344  ? 228 HIS A C   1 
ATOM   1831 O O   . HIS B 2 230 ? 42.21935 -35.10967 27.22280  1.000 19.73344  ? 228 HIS A O   1 
ATOM   1832 C CB  . HIS B 2 230 ? 45.28153 -34.48335 26.35241  1.000 28.65344  ? 228 HIS A CB  1 
ATOM   1833 C CG  . HIS B 2 230 ? 46.19943 -33.42526 25.82454  1.000 32.16344  ? 228 HIS A CG  1 
ATOM   1834 N ND1 . HIS B 2 230 ? 47.24434 -32.90702 26.56188  1.000 33.85344  ? 228 HIS A ND1 1 
ATOM   1835 C CD2 . HIS B 2 230 ? 46.23275 -32.79398 24.62722  1.000 30.95344  ? 228 HIS A CD2 1 
ATOM   1836 C CE1 . HIS B 2 230 ? 47.87995 -32.00026 25.83906  1.000 39.88344  ? 228 HIS A CE1 1 
ATOM   1837 N NE2 . HIS B 2 230 ? 47.28521 -31.91227 24.66152  1.000 33.61344  ? 228 HIS A NE2 1 
ATOM   1838 N N   . ILE B 2 231 ? 43.67679 -35.97001 28.71257  1.000 21.56502  ? 229 ILE A N   1 
ATOM   1839 C CA  . ILE B 2 231 ? 42.79605 -37.07497 29.08466  1.000 20.48502  ? 229 ILE A CA  1 
ATOM   1840 C C   . ILE B 2 231 ? 41.64532 -36.57850 29.94688  1.000 19.83502  ? 229 ILE A C   1 
ATOM   1841 O O   . ILE B 2 231 ? 40.48593 -36.94430 29.72325  1.000 18.10502  ? 229 ILE A O   1 
ATOM   1842 C CB  . ILE B 2 231 ? 43.59901 -38.17799 29.80581  1.000 21.04502  ? 229 ILE A CB  1 
ATOM   1843 C CG1 . ILE B 2 231 ? 44.72435 -38.68384 28.90849  1.000 18.09502  ? 229 ILE A CG1 1 
ATOM   1844 C CG2 . ILE B 2 231 ? 42.68341 -39.32212 30.22590  1.000 24.02502  ? 229 ILE A CG2 1 
ATOM   1845 C CD1 . ILE B 2 231 ? 44.25084 -39.25999 27.61348  1.000 19.28502  ? 229 ILE A CD1 1 
ATOM   1846 N N   . ASP B 2 232 ? 41.96293 -35.77311 30.97038  1.000 16.33815  ? 230 ASP A N   1 
ATOM   1847 C CA  . ASP B 2 232 ? 40.94134 -35.15036 31.80705  1.000 22.99815  ? 230 ASP A CA  1 
ATOM   1848 C C   . ASP B 2 232 ? 39.94007 -34.35955 30.96679  1.000 22.68815  ? 230 ASP A C   1 
ATOM   1849 O O   . ASP B 2 232 ? 38.72405 -34.41601 31.20163  1.000 18.08815  ? 230 ASP A O   1 
ATOM   1850 C CB  . ASP B 2 232 ? 41.61860 -34.23480 32.82533  1.000 28.87815  ? 230 ASP A CB  1 
ATOM   1851 C CG  . ASP B 2 232 ? 40.63840 -33.60686 33.78563  1.000 39.92815  ? 230 ASP A CG  1 
ATOM   1852 O OD1 . ASP B 2 232 ? 39.73220 -34.33368 34.24437  1.000 47.58815  ? 230 ASP A OD1 1 
ATOM   1853 O OD2 . ASP B 2 232 ? 40.77790 -32.39821 34.10137  1.000 45.39815  ? 230 ASP A OD2 1 
ATOM   1854 N N   . GLN B 2 233 ? 40.44581 -33.64892 29.96197  1.000 19.46852  ? 231 GLN A N   1 
ATOM   1855 C CA  . GLN B 2 233 ? 39.60920 -32.85092 29.07260  1.000 21.54852  ? 231 GLN A CA  1 
ATOM   1856 C C   . GLN B 2 233 ? 38.71839 -33.73305 28.20178  1.000 16.58852  ? 231 GLN A C   1 
ATOM   1857 O O   . GLN B 2 233 ? 37.51999 -33.45644 28.03760  1.000 16.03852  ? 231 GLN A O   1 
ATOM   1858 C CB  . GLN B 2 233 ? 40.50862 -31.97574 28.20429  1.000 22.80852  ? 231 GLN A CB  1 
ATOM   1859 C CG  . GLN B 2 233 ? 39.77375 -31.12700 27.17838  1.000 29.05852  ? 231 GLN A CG  1 
ATOM   1860 C CD  . GLN B 2 233 ? 39.46261 -29.74678 27.67849  1.000 34.41852  ? 231 GLN A CD  1 
ATOM   1861 O OE1 . GLN B 2 233 ? 39.97200 -29.31910 28.71208  1.000 53.75852  ? 231 GLN A OE1 1 
ATOM   1862 N NE2 . GLN B 2 233 ? 38.61169 -29.03504 26.94991  1.000 41.24852  ? 231 GLN A NE2 1 
ATOM   1863 N N   . LEU B 2 234 ? 39.29433 -34.78460 27.61283  1.000 16.38949  ? 232 LEU A N   1 
ATOM   1864 C CA  . LEU B 2 234 ? 38.51014 -35.69378 26.78963  1.000 18.02949  ? 232 LEU A CA  1 
ATOM   1865 C C   . LEU B 2 234 ? 37.39121 -36.34187 27.59543  1.000 19.36949  ? 232 LEU A C   1 
ATOM   1866 O O   . LEU B 2 234 ? 36.26554 -36.46971 27.10154  1.000 18.52949  ? 232 LEU A O   1 
ATOM   1867 C CB  . LEU B 2 234 ? 39.40864 -36.75627 26.16749  1.000 20.61949  ? 232 LEU A CB  1 
ATOM   1868 C CG  . LEU B 2 234 ? 38.67376 -37.80522 25.32603  1.000 23.21949  ? 232 LEU A CG  1 
ATOM   1869 C CD1 . LEU B 2 234 ? 38.15378 -37.18957 24.04767  1.000 25.80949  ? 232 LEU A CD1 1 
ATOM   1870 C CD2 . LEU B 2 234 ? 39.53382 -39.01620 25.01454  1.000 25.14949  ? 232 LEU A CD2 1 
ATOM   1871 N N   . LYS B 2 235 ? 37.66360 -36.70842 28.85428  1.000 16.67722  ? 233 LYS A N   1 
ATOM   1872 C CA  . LYS B 2 235 ? 36.63156 -37.34893 29.66716  1.000 19.36722  ? 233 LYS A CA  1 
ATOM   1873 C C   . LYS B 2 235 ? 35.49769 -36.38324 30.01032  1.000 18.14722  ? 233 LYS A C   1 
ATOM   1874 O O   . LYS B 2 235 ? 34.32623 -36.77978 30.04521  1.000 14.58722  ? 233 LYS A O   1 
ATOM   1875 C CB  . LYS B 2 235 ? 37.25218 -37.92507 30.93764  1.000 20.73722  ? 233 LYS A CB  1 
ATOM   1876 C CG  . LYS B 2 235 ? 38.08658 -39.17823 30.70451  1.000 23.43722  ? 233 LYS A CG  1 
ATOM   1877 C CD  . LYS B 2 235 ? 38.83601 -39.53753 31.98872  1.000 28.15722  ? 233 LYS A CD  1 
ATOM   1878 C CE  . LYS B 2 235 ? 39.63886 -40.82958 31.86777  1.000 32.89722  ? 233 LYS A CE  1 
ATOM   1879 N NZ  . LYS B 2 235 ? 40.39214 -41.08550 33.15487  1.000 33.84722  ? 233 LYS A NZ  1 
ATOM   1880 N N   . LEU B 2 236 ? 35.81768 -35.11142 30.25304  1.000 16.42983  ? 234 LEU A N   1 
ATOM   1881 C CA  . LEU B 2 236 ? 34.76859 -34.12147 30.47268  1.000 16.31983  ? 234 LEU A CA  1 
ATOM   1882 C C   . LEU B 2 236 ? 33.92021 -33.91860 29.22260  1.000 15.04983  ? 234 LEU A C   1 
ATOM   1883 O O   . LEU B 2 236 ? 32.69774 -33.75885 29.31473  1.000 19.40983  ? 234 LEU A O   1 
ATOM   1884 C CB  . LEU B 2 236 ? 35.38638 -32.79270 30.89578  1.000 20.56983  ? 234 LEU A CB  1 
ATOM   1885 C CG  . LEU B 2 236 ? 36.07787 -32.69682 32.24146  1.000 21.36983  ? 234 LEU A CG  1 
ATOM   1886 C CD1 . LEU B 2 236 ? 36.73842 -31.31120 32.37202  1.000 23.85983  ? 234 LEU A CD1 1 
ATOM   1887 C CD2 . LEU B 2 236 ? 35.06967 -32.92631 33.33418  1.000 23.93983  ? 234 LEU A CD2 1 
ATOM   1888 N N   . ILE B 2 237 ? 34.55760 -33.88257 28.05413  1.000 16.42888  ? 235 ILE A N   1 
ATOM   1889 C CA  . ILE B 2 237 ? 33.82616 -33.72527 26.80385  1.000 17.66888  ? 235 ILE A CA  1 
ATOM   1890 C C   . ILE B 2 237 ? 32.92196 -34.92817 26.56856  1.000 20.13888  ? 235 ILE A C   1 
ATOM   1891 O O   . ILE B 2 237 ? 31.72495 -34.77489 26.29852  1.000 16.15888  ? 235 ILE A O   1 
ATOM   1892 C CB  . ILE B 2 237 ? 34.80559 -33.51418 25.63930  1.000 16.24888  ? 235 ILE A CB  1 
ATOM   1893 C CG1 . ILE B 2 237 ? 35.49195 -32.15067 25.77581  1.000 17.08888  ? 235 ILE A CG1 1 
ATOM   1894 C CG2 . ILE B 2 237 ? 34.10333 -33.67041 24.29676  1.000 17.99888  ? 235 ILE A CG2 1 
ATOM   1895 C CD1 . ILE B 2 237 ? 36.60035 -31.94280 24.77313  1.000 16.44888  ? 235 ILE A CD1 1 
ATOM   1896 N N   . LEU B 2 238 ? 33.47204 -36.14695 26.71705  1.000 18.51881  ? 236 LEU A N   1 
ATOM   1897 C CA  . LEU B 2 238 ? 32.69831 -37.34487 26.40131  1.000 19.67881  ? 236 LEU A CA  1 
ATOM   1898 C C   . LEU B 2 238 ? 31.55309 -37.53871 27.37437  1.000 19.99881  ? 236 LEU A C   1 
ATOM   1899 O O   . LEU B 2 238 ? 30.53693 -38.13973 27.01566  1.000 23.92881  ? 236 LEU A O   1 
ATOM   1900 C CB  . LEU B 2 238 ? 33.59510 -38.58039 26.38791  1.000 20.25881  ? 236 LEU A CB  1 
ATOM   1901 C CG  . LEU B 2 238 ? 34.63173 -38.59934 25.26453  1.000 22.19881  ? 236 LEU A CG  1 
ATOM   1902 C CD1 . LEU B 2 238 ? 35.32437 -39.94315 25.21054  1.000 24.21881  ? 236 LEU A CD1 1 
ATOM   1903 C CD2 . LEU B 2 238 ? 34.03230 -38.23708 23.90761  1.000 23.37881  ? 236 LEU A CD2 1 
ATOM   1904 N N   . ARG B 2 239 ? 31.68339 -37.00117 28.58669  1.000 15.64591  ? 237 ARG A N   1 
ATOM   1905 C CA  . ARG B 2 239 ? 30.61271 -37.08277 29.56431  1.000 19.91591  ? 237 ARG A CA  1 
ATOM   1906 C C   . ARG B 2 239 ? 29.38809 -36.28735 29.12192  1.000 21.89591  ? 237 ARG A C   1 
ATOM   1907 O O   . ARG B 2 239 ? 28.25391 -36.68568 29.41191  1.000 25.86591  ? 237 ARG A O   1 
ATOM   1908 C CB  . ARG B 2 239 ? 31.12024 -36.58613 30.91328  1.000 23.87591  ? 237 ARG A CB  1 
ATOM   1909 C CG  . ARG B 2 239 ? 30.25725 -36.94974 32.08408  1.000 33.67591  ? 237 ARG A CG  1 
ATOM   1910 C CD  . ARG B 2 239 ? 30.94050 -36.56437 33.38884  1.000 42.17591  ? 237 ARG A CD  1 
ATOM   1911 N NE  . ARG B 2 239 ? 32.31958 -37.03743 33.45460  1.000 46.18591  ? 237 ARG A NE  1 
ATOM   1912 C CZ  . ARG B 2 239 ? 33.23562 -36.55777 34.28812  1.000 50.67591  ? 237 ARG A CZ  1 
ATOM   1913 N NH1 . ARG B 2 239 ? 32.94634 -35.59518 35.14879  1.000 46.73591  ? 237 ARG A NH1 1 
ATOM   1914 N NH2 . ARG B 2 239 ? 34.47660 -37.04658 34.24669  1.000 40.57591  ? 237 ARG A NH2 1 
ATOM   1915 N N   . LEU B 2 240 ? 29.58928 -35.17806 28.40922  1.000 20.43915  ? 238 LEU A N   1 
ATOM   1916 C CA  . LEU B 2 240 ? 28.45793 -34.38448 27.95398  1.000 19.95915  ? 238 LEU A CA  1 
ATOM   1917 C C   . LEU B 2 240 ? 27.91135 -34.87890 26.62258  1.000 18.35915  ? 238 LEU A C   1 
ATOM   1918 O O   . LEU B 2 240 ? 26.69388 -34.99266 26.46286  1.000 19.49915  ? 238 LEU A O   1 
ATOM   1919 C CB  . LEU B 2 240 ? 28.85091 -32.90698 27.82734  1.000 19.80915  ? 238 LEU A CB  1 
ATOM   1920 C CG  . LEU B 2 240 ? 27.71396 -31.97368 27.38845  1.000 20.77915  ? 238 LEU A CG  1 
ATOM   1921 C CD1 . LEU B 2 240 ? 26.73272 -31.72844 28.53498  1.000 20.94915  ? 238 LEU A CD1 1 
ATOM   1922 C CD2 . LEU B 2 240 ? 28.26475 -30.65390 26.85094  1.000 25.56915  ? 238 LEU A CD2 1 
ATOM   1923 N N   . VAL B 2 241 ? 28.78168 -35.19500 25.66078  1.000 18.02212  ? 239 VAL A N   1 
ATOM   1924 C CA  . VAL B 2 241 ? 28.33570 -35.44563 24.29425  1.000 19.14212  ? 239 VAL A CA  1 
ATOM   1925 C C   . VAL B 2 241 ? 28.29375 -36.93046 23.94246  1.000 22.05212  ? 239 VAL A C   1 
ATOM   1926 O O   . VAL B 2 241 ? 27.83128 -37.27992 22.84736  1.000 24.59212  ? 239 VAL A O   1 
ATOM   1927 C CB  . VAL B 2 241 ? 29.20739 -34.66542 23.28603  1.000 19.71212  ? 239 VAL A CB  1 
ATOM   1928 C CG1 . VAL B 2 241 ? 29.27664 -33.18785 23.69106  1.000 19.81212  ? 239 VAL A CG1 1 
ATOM   1929 C CG2 . VAL B 2 241 ? 30.61830 -35.27281 23.17797  1.000 21.07212  ? 239 VAL A CG2 1 
ATOM   1930 N N   . GLY B 2 242 ? 28.74489 -37.81208 24.83447  1.000 24.66642  ? 240 GLY A N   1 
ATOM   1931 C CA  . GLY B 2 242 ? 28.73302 -39.23946 24.58396  1.000 24.70642  ? 240 GLY A CA  1 
ATOM   1932 C C   . GLY B 2 242 ? 30.02626 -39.74653 23.96344  1.000 26.82642  ? 240 GLY A C   1 
ATOM   1933 O O   . GLY B 2 242 ? 30.81508 -39.00016 23.38370  1.000 28.15642  ? 240 GLY A O   1 
ATOM   1934 N N   . THR B 2 243 ? 30.24760 -41.05299 24.10467  1.000 31.83061  ? 241 THR A N   1 
ATOM   1935 C CA  . THR B 2 243 ? 31.41075 -41.68346 23.49732  1.000 31.38061  ? 241 THR A CA  1 
ATOM   1936 C C   . THR B 2 243 ? 31.20052 -41.80282 21.99047  1.000 26.10061  ? 241 THR A C   1 
ATOM   1937 O O   . THR B 2 243 ? 30.06434 -41.78604 21.51701  1.000 25.68061  ? 241 THR A O   1 
ATOM   1938 C CB  . THR B 2 243 ? 31.66488 -43.05851 24.12238  1.000 33.20061  ? 241 THR A CB  1 
ATOM   1939 O OG1 . THR B 2 243 ? 30.42379 -43.65115 24.50513  1.000 33.46061  ? 241 THR A OG1 1 
ATOM   1940 C CG2 . THR B 2 243 ? 32.56551 -42.93494 25.34620  1.000 36.32061  ? 241 THR A CG2 1 
ATOM   1941 N N   . PRO B 2 244 ? 32.28191 -41.88806 21.21328  1.000 26.26470  ? 242 PRO A N   1 
ATOM   1942 C CA  . PRO B 2 244 ? 32.13494 -42.01474 19.75675  1.000 30.19470  ? 242 PRO A CA  1 
ATOM   1943 C C   . PRO B 2 244 ? 31.41039 -43.29353 19.35058  1.000 37.21470  ? 242 PRO A C   1 
ATOM   1944 O O   . PRO B 2 244 ? 31.72225 -44.38624 19.82683  1.000 26.83470  ? 242 PRO A O   1 
ATOM   1945 C CB  . PRO B 2 244 ? 33.58612 -42.01654 19.25792  1.000 29.92470  ? 242 PRO A CB  1 
ATOM   1946 C CG  . PRO B 2 244 ? 34.34339 -41.29671 20.31023  1.000 28.81470  ? 242 PRO A CG  1 
ATOM   1947 C CD  . PRO B 2 244 ? 33.68440 -41.63271 21.60043  1.000 27.88470  ? 242 PRO A CD  1 
ATOM   1948 N N   . GLY B 2 245 ? 30.42667 -43.14193 18.46584  1.000 35.91720  ? 243 GLY A N   1 
ATOM   1949 C CA  . GLY B 2 245 ? 29.76147 -44.27533 17.86621  1.000 32.57720  ? 243 GLY A CA  1 
ATOM   1950 C C   . GLY B 2 245 ? 30.60162 -44.87941 16.76364  1.000 39.34720  ? 243 GLY A C   1 
ATOM   1951 O O   . GLY B 2 245 ? 31.67776 -44.38870 16.42169  1.000 38.22720  ? 243 GLY A O   1 
ATOM   1952 N N   . ALA B 2 246 ? 30.08269 -45.96993 16.18955  1.000 39.48951  ? 244 ALA A N   1 
ATOM   1953 C CA  . ALA B 2 246 ? 30.85530 -46.73352 15.21552  1.000 41.13951  ? 244 ALA A CA  1 
ATOM   1954 C C   . ALA B 2 246 ? 31.13342 -45.93336 13.95074  1.000 38.88951  ? 244 ALA A C   1 
ATOM   1955 O O   . ALA B 2 246 ? 32.17536 -46.13435 13.31853  1.000 38.74951  ? 244 ALA A O   1 
ATOM   1956 C CB  . ALA B 2 246 ? 30.13297 -48.03630 14.87342  1.000 43.32951  ? 244 ALA A CB  1 
ATOM   1957 N N   . GLU B 2 247 ? 30.23559 -45.01116 13.58167  1.000 38.60143  ? 245 GLU A N   1 
ATOM   1958 C CA  . GLU B 2 247 ? 30.45334 -44.20720 12.38278  1.000 40.79143  ? 245 GLU A CA  1 
ATOM   1959 C C   . GLU B 2 247 ? 31.64991 -43.27839 12.54838  1.000 33.13143  ? 245 GLU A C   1 
ATOM   1960 O O   . GLU B 2 247 ? 32.44501 -43.11040 11.61518  1.000 35.92143  ? 245 GLU A O   1 
ATOM   1961 C CB  . GLU B 2 247 ? 29.19687 -43.39954 12.04778  1.000 50.34143  ? 245 GLU A CB  1 
ATOM   1962 C CG  . GLU B 2 247 ? 29.34428 -42.53360 10.79506  1.000 57.98143  ? 245 GLU A CG  1 
ATOM   1963 C CD  . GLU B 2 247 ? 28.08257 -41.75476 10.44900  1.000 70.54143  ? 245 GLU A CD  1 
ATOM   1964 O OE1 . GLU B 2 247 ? 27.34013 -41.36278 11.37609  1.000 62.21143  ? 245 GLU A OE1 1 
ATOM   1965 O OE2 . GLU B 2 247 ? 27.83391 -41.53609 9.24292   1.000 74.57143  ? 245 GLU A OE2 1 
ATOM   1966 N N   . LEU B 2 248 ? 31.79951 -42.67895 13.73508  1.000 33.19370  ? 246 LEU A N   1 
ATOM   1967 C CA  . LEU B 2 248 ? 32.89695 -41.74496 13.97244  1.000 35.74370  ? 246 LEU A CA  1 
ATOM   1968 C C   . LEU B 2 248 ? 34.23063 -42.47479 14.11146  1.000 34.22370  ? 246 LEU A C   1 
ATOM   1969 O O   . LEU B 2 248 ? 35.26034 -41.99569 13.61608  1.000 29.47370  ? 246 LEU A O   1 
ATOM   1970 C CB  . LEU B 2 248 ? 32.59895 -40.91483 15.22184  1.000 36.30370  ? 246 LEU A CB  1 
ATOM   1971 C CG  . LEU B 2 248 ? 33.67202 -39.92643 15.68606  1.000 37.48370  ? 246 LEU A CG  1 
ATOM   1972 C CD1 . LEU B 2 248 ? 34.01899 -38.94661 14.57824  1.000 39.42370  ? 246 LEU A CD1 1 
ATOM   1973 C CD2 . LEU B 2 248 ? 33.19097 -39.17988 16.91238  1.000 36.63370  ? 246 LEU A CD2 1 
ATOM   1974 N N   . LEU B 2 249 ? 34.22067 -43.64108 14.77523  1.000 32.05113  ? 247 LEU A N   1 
ATOM   1975 C CA  . LEU B 2 249 ? 35.42574 -44.45503 14.94683  1.000 36.50113  ? 247 LEU A CA  1 
ATOM   1976 C C   . LEU B 2 249 ? 36.06113 -44.85136 13.61783  1.000 35.61113  ? 247 LEU A C   1 
ATOM   1977 O O   . LEU B 2 249 ? 37.28969 -44.95665 13.53093  1.000 38.81113  ? 247 LEU A O   1 
ATOM   1978 C CB  . LEU B 2 249 ? 35.08888 -45.70554 15.75696  1.000 38.66113  ? 247 LEU A CB  1 
ATOM   1979 C CG  . LEU B 2 249 ? 35.14429 -45.56770 17.27353  1.000 44.71113  ? 247 LEU A CG  1 
ATOM   1980 C CD1 . LEU B 2 249 ? 34.31430 -46.66028 17.93619  1.000 47.11113  ? 247 LEU A CD1 1 
ATOM   1981 C CD2 . LEU B 2 249 ? 36.59652 -45.62961 17.73664  1.000 46.72113  ? 247 LEU A CD2 1 
ATOM   1982 N N   . LYS B 2 250 ? 35.24820 -45.06676 12.57823  1.000 31.52237  ? 248 LYS A N   1 
ATOM   1983 C CA  . LYS B 2 250 ? 35.77460 -45.35676 11.24383  1.000 39.81237  ? 248 LYS A CA  1 
ATOM   1984 C C   . LYS B 2 250 ? 36.63059 -44.21129 10.70900  1.000 40.81237  ? 248 LYS A C   1 
ATOM   1985 O O   . LYS B 2 250 ? 37.59306 -44.44544 9.96746   1.000 43.81237  ? 248 LYS A O   1 
ATOM   1986 C CB  . LYS B 2 250 ? 34.60870 -45.64716 10.28899  1.000 49.25237  ? 248 LYS A CB  1 
ATOM   1987 C CG  . LYS B 2 250 ? 34.98088 -46.13874 8.87985   1.000 63.31237  ? 248 LYS A CG  1 
ATOM   1988 C CD  . LYS B 2 250 ? 34.97834 -45.01231 7.82842   1.000 73.31237  ? 248 LYS A CD  1 
ATOM   1989 C CE  . LYS B 2 250 ? 33.66893 -44.21783 7.82443   1.000 74.53237  ? 248 LYS A CE  1 
ATOM   1990 N NZ  . LYS B 2 250 ? 33.67692 -43.10906 6.82147   1.000 72.36237  ? 248 LYS A NZ  1 
ATOM   1991 N N   . LYS B 2 251 ? 36.30000 -42.97176 11.06851  1.000 37.28156  ? 249 LYS A N   1 
ATOM   1992 C CA  . LYS B 2 251 ? 36.99619 -41.81419 10.52547  1.000 36.73156  ? 249 LYS A CA  1 
ATOM   1993 C C   . LYS B 2 251 ? 38.30343 -41.50527 11.24793  1.000 38.32156  ? 249 LYS A C   1 
ATOM   1994 O O   . LYS B 2 251 ? 39.10925 -40.72533 10.72580  1.000 41.20156  ? 249 LYS A O   1 
ATOM   1995 C CB  . LYS B 2 251 ? 36.07304 -40.59392 10.56868  1.000 41.95156  ? 249 LYS A CB  1 
ATOM   1996 C CG  . LYS B 2 251 ? 34.71896 -40.81935 9.90156   1.000 47.14156  ? 249 LYS A CG  1 
ATOM   1997 C CD  . LYS B 2 251 ? 33.80771 -39.60197 10.06784  1.000 50.37156  ? 249 LYS A CD  1 
ATOM   1998 C CE  . LYS B 2 251 ? 32.42743 -39.85609 9.48630   1.000 50.23156  ? 249 LYS A CE  1 
ATOM   1999 N NZ  . LYS B 2 251 ? 31.47966 -38.75053 9.80570   1.000 47.09156  ? 249 LYS A NZ  1 
ATOM   2000 N N   . ILE B 2 252 ? 38.54235 -42.10367 12.41195  1.000 40.47244  ? 250 ILE A N   1 
ATOM   2001 C CA  . ILE B 2 252 ? 39.75392 -41.84297 13.18426  1.000 39.19244  ? 250 ILE A CA  1 
ATOM   2002 C C   . ILE B 2 252 ? 40.89404 -42.69085 12.63346  1.000 39.04244  ? 250 ILE A C   1 
ATOM   2003 O O   . ILE B 2 252 ? 40.79846 -43.92014 12.58534  1.000 42.44244  ? 250 ILE A O   1 
ATOM   2004 C CB  . ILE B 2 252 ? 39.51881 -42.11543 14.67486  1.000 36.46244  ? 250 ILE A CB  1 
ATOM   2005 C CG1 . ILE B 2 252 ? 38.60152 -41.03164 15.23511  1.000 32.78244  ? 250 ILE A CG1 1 
ATOM   2006 C CG2 . ILE B 2 252 ? 40.84713 -42.17943 15.42731  1.000 35.53244  ? 250 ILE A CG2 1 
ATOM   2007 C CD1 . ILE B 2 252 ? 37.89646 -41.38756 16.49166  1.000 31.39244  ? 250 ILE A CD1 1 
ATOM   2008 N N   . SER B 2 253 ? 41.98832 -42.02998 12.24391  1.000 39.52570  ? 251 SER A N   1 
ATOM   2009 C CA  . SER B 2 253 ? 43.03148 -42.66552 11.44370  1.000 43.91570  ? 251 SER A CA  1 
ATOM   2010 C C   . SER B 2 253 ? 43.98393 -43.51647 12.27956  1.000 45.89570  ? 251 SER A C   1 
ATOM   2011 O O   . SER B 2 253 ? 44.34177 -44.62708 11.86942  1.000 47.91570  ? 251 SER A O   1 
ATOM   2012 C CB  . SER B 2 253 ? 43.81019 -41.59728 10.67833  1.000 54.26570  ? 251 SER A CB  1 
ATOM   2013 O OG  . SER B 2 253 ? 42.92300 -40.70767 10.01640  1.000 59.78570  ? 251 SER A OG  1 
ATOM   2014 N N   . SER B 2 254 ? 44.42558 -43.01759 13.43292  1.000 46.33133  ? 252 SER A N   1 
ATOM   2015 C CA  . SER B 2 254 ? 45.38234 -43.76346 14.24575  1.000 46.20133  ? 252 SER A CA  1 
ATOM   2016 C C   . SER B 2 254 ? 44.70361 -44.94584 14.93150  1.000 44.52133  ? 252 SER A C   1 
ATOM   2017 O O   . SER B 2 254 ? 43.68891 -44.77593 15.61453  1.000 39.02133  ? 252 SER A O   1 
ATOM   2018 C CB  . SER B 2 254 ? 46.02149 -42.85079 15.29046  1.000 47.71133  ? 252 SER A CB  1 
ATOM   2019 O OG  . SER B 2 254 ? 46.73020 -43.61160 16.25743  1.000 55.58133  ? 252 SER A OG  1 
ATOM   2020 N N   . GLU B 2 255 ? 45.27273 -46.14634 14.75367  1.000 42.91177  ? 253 GLU A N   1 
ATOM   2021 C CA  . GLU B 2 255 ? 44.71692 -47.33482 15.39738  1.000 41.43177  ? 253 GLU A CA  1 
ATOM   2022 C C   . GLU B 2 255 ? 44.81413 -47.23690 16.91434  1.000 39.25177  ? 253 GLU A C   1 
ATOM   2023 O O   . GLU B 2 255 ? 43.90510 -47.67868 17.62885  1.000 44.65177  ? 253 GLU A O   1 
ATOM   2024 C CB  . GLU B 2 255 ? 45.43105 -48.59165 14.89692  1.000 48.56177  ? 253 GLU A CB  1 
ATOM   2025 C CG  . GLU B 2 255 ? 44.88214 -49.89810 15.46411  1.000 56.17177  ? 253 GLU A CG  1 
ATOM   2026 C CD  . GLU B 2 255 ? 45.68963 -51.11208 15.03261  1.000 65.72177  ? 253 GLU A CD  1 
ATOM   2027 O OE1 . GLU B 2 255 ? 46.54486 -50.96708 14.13023  1.000 70.40177  ? 253 GLU A OE1 1 
ATOM   2028 O OE2 . GLU B 2 255 ? 45.47232 -52.20963 15.59670  1.000 67.76177  ? 253 GLU A OE2 1 
ATOM   2029 N N   . SER B 2 256 ? 45.90669 -46.64914 17.42078  1.000 39.91226  ? 254 SER A N   1 
ATOM   2030 C CA  . SER B 2 256 ? 46.07886 -46.48529 18.86280  1.000 38.77226  ? 254 SER A CA  1 
ATOM   2031 C C   . SER B 2 256 ? 44.98485 -45.60340 19.45405  1.000 33.12226  ? 254 SER A C   1 
ATOM   2032 O O   . SER B 2 256 ? 44.44352 -45.90668 20.52540  1.000 36.73226  ? 254 SER A O   1 
ATOM   2033 C CB  . SER B 2 256 ? 47.46169 -45.89676 19.16032  1.000 39.96226  ? 254 SER A CB  1 
ATOM   2034 O OG  . SER B 2 256 ? 47.73262 -45.87666 20.56268  1.000 36.56226  ? 254 SER A OG  1 
ATOM   2035 N N   . ALA B 2 257 ? 44.64812 -44.50878 18.76456  1.000 34.80532  ? 255 ALA A N   1 
ATOM   2036 C CA  . ALA B 2 257 ? 43.54616 -43.65566 19.20224  1.000 35.51532  ? 255 ALA A CA  1 
ATOM   2037 C C   . ALA B 2 257 ? 42.22595 -44.41788 19.20138  1.000 34.97532  ? 255 ALA A C   1 
ATOM   2038 O O   . ALA B 2 257 ? 41.42898 -44.28508 20.13816  1.000 36.36532  ? 255 ALA A O   1 
ATOM   2039 C CB  . ALA B 2 257 ? 43.45491 -42.41466 18.31252  1.000 37.94532  ? 255 ALA A CB  1 
ATOM   2040 N N   . ARG B 2 258 ? 41.99531 -45.24665 18.17465  1.000 35.80670  ? 256 ARG A N   1 
ATOM   2041 C CA  . ARG B 2 258 ? 40.78740 -46.07157 18.12980  1.000 39.59670  ? 256 ARG A CA  1 
ATOM   2042 C C   . ARG B 2 258 ? 40.75158 -47.07470 19.27783  1.000 34.97670  ? 256 ARG A C   1 
ATOM   2043 O O   . ARG B 2 258 ? 39.71753 -47.23727 19.93876  1.000 31.86670  ? 256 ARG A O   1 
ATOM   2044 C CB  . ARG B 2 258 ? 40.68669 -46.80116 16.78923  1.000 38.07670  ? 256 ARG A CB  1 
ATOM   2045 C CG  . ARG B 2 258 ? 40.28075 -45.91753 15.64116  1.000 43.92670  ? 256 ARG A CG  1 
ATOM   2046 C CD  . ARG B 2 258 ? 39.82971 -46.74082 14.44417  1.000 44.55670  ? 256 ARG A CD  1 
ATOM   2047 N NE  . ARG B 2 258 ? 40.77337 -47.79343 14.08786  1.000 41.86670  ? 256 ARG A NE  1 
ATOM   2048 C CZ  . ARG B 2 258 ? 41.73592 -47.66931 13.18465  1.000 43.46670  ? 256 ARG A CZ  1 
ATOM   2049 N NH1 . ARG B 2 258 ? 41.93552 -46.53224 12.53854  1.000 52.10670  ? 256 ARG A NH1 1 
ATOM   2050 N NH2 . ARG B 2 258 ? 42.51581 -48.71437 12.91953  1.000 46.14670  ? 256 ARG A NH2 1 
ATOM   2051 N N   . ASN B 2 259 ? 41.87313 -47.76444 19.52562  1.000 33.41574  ? 257 ASN A N   1 
ATOM   2052 C CA  . ASN B 2 259 ? 41.92441 -48.70432 20.64348  1.000 34.25574  ? 257 ASN A CA  1 
ATOM   2053 C C   . ASN B 2 259 ? 41.72927 -47.99918 21.97307  1.000 26.19574  ? 257 ASN A C   1 
ATOM   2054 O O   . ASN B 2 259 ? 41.11489 -48.56304 22.88794  1.000 28.99574  ? 257 ASN A O   1 
ATOM   2055 C CB  . ASN B 2 259 ? 43.25020 -49.46952 20.66560  1.000 42.36574  ? 257 ASN A CB  1 
ATOM   2056 C CG  . ASN B 2 259 ? 43.44741 -50.33771 19.44098  1.000 46.52574  ? 257 ASN A CG  1 
ATOM   2057 O OD1 . ASN B 2 259 ? 44.54309 -50.39703 18.88414  1.000 57.31574  ? 257 ASN A OD1 1 
ATOM   2058 N ND2 . ASN B 2 259 ? 42.38844 -51.01920 19.01469  1.000 51.40574  ? 257 ASN A ND2 1 
ATOM   2059 N N   . TYR B 2 260 ? 42.24254 -46.77386 22.10929  1.000 28.44275  ? 258 TYR A N   1 
ATOM   2060 C CA  . TYR B 2 260 ? 42.03556 -46.04769 23.35984  1.000 26.75275  ? 258 TYR A CA  1 
ATOM   2061 C C   . TYR B 2 260 ? 40.56112 -45.70883 23.55267  1.000 27.61275  ? 258 TYR A C   1 
ATOM   2062 O O   . TYR B 2 260 ? 40.00316 -45.91682 24.63925  1.000 27.80275  ? 258 TYR A O   1 
ATOM   2063 C CB  . TYR B 2 260 ? 42.88442 -44.77153 23.41361  1.000 25.64275  ? 258 TYR A CB  1 
ATOM   2064 C CG  . TYR B 2 260 ? 42.54179 -43.97787 24.65111  1.000 22.46275  ? 258 TYR A CG  1 
ATOM   2065 C CD1 . TYR B 2 260 ? 42.69117 -44.54395 25.90265  1.000 21.86275  ? 258 TYR A CD1 1 
ATOM   2066 C CD2 . TYR B 2 260 ? 42.00768 -42.69742 24.57232  1.000 23.41275  ? 258 TYR A CD2 1 
ATOM   2067 C CE1 . TYR B 2 260 ? 42.35324 -43.86611 27.03606  1.000 20.35275  ? 258 TYR A CE1 1 
ATOM   2068 C CE2 . TYR B 2 260 ? 41.66173 -42.00203 25.71774  1.000 20.37275  ? 258 TYR A CE2 1 
ATOM   2069 C CZ  . TYR B 2 260 ? 41.84503 -42.60277 26.94809  1.000 21.01275  ? 258 TYR A CZ  1 
ATOM   2070 O OH  . TYR B 2 260 ? 41.52543 -41.96457 28.11994  1.000 22.28275  ? 258 TYR A OH  1 
ATOM   2071 N N   . ILE B 2 261 ? 39.91265 -45.20807 22.49558  1.000 30.33055  ? 259 ILE A N   1 
ATOM   2072 C CA  . ILE B 2 261 ? 38.49714 -44.83946 22.56479  1.000 31.24055  ? 259 ILE A CA  1 
ATOM   2073 C C   . ILE B 2 261 ? 37.63588 -46.05760 22.87091  1.000 29.47055  ? 259 ILE A C   1 
ATOM   2074 O O   . ILE B 2 261 ? 36.76751 -46.01528 23.74852  1.000 29.54055  ? 259 ILE A O   1 
ATOM   2075 C CB  . ILE B 2 261 ? 38.06589 -44.16170 21.25501  1.000 32.02055  ? 259 ILE A CB  1 
ATOM   2076 C CG1 . ILE B 2 261 ? 38.66686 -42.76869 21.18306  1.000 31.62055  ? 259 ILE A CG1 1 
ATOM   2077 C CG2 . ILE B 2 261 ? 36.55093 -44.09541 21.14945  1.000 33.44055  ? 259 ILE A CG2 1 
ATOM   2078 C CD1 . ILE B 2 261 ? 38.85289 -42.31745 19.80169  1.000 35.21055  ? 259 ILE A CD1 1 
ATOM   2079 N N   . GLN B 2 262 ? 37.89615 -47.17493 22.18125  1.000 28.27756  ? 260 GLN A N   1 
ATOM   2080 C CA  . GLN B 2 262 ? 37.18246 -48.42198 22.45486  1.000 32.87756  ? 260 GLN A CA  1 
ATOM   2081 C C   . GLN B 2 262 ? 37.45164 -48.97794 23.84829  1.000 31.48756  ? 260 GLN A C   1 
ATOM   2082 O O   . GLN B 2 262 ? 36.68377 -49.82347 24.32012  1.000 38.26756  ? 260 GLN A O   1 
ATOM   2083 C CB  . GLN B 2 262 ? 37.55460 -49.47933 21.42176  1.000 38.31756  ? 260 GLN A CB  1 
ATOM   2084 C CG  . GLN B 2 262 ? 37.06301 -49.19506 20.02172  1.000 39.74756  ? 260 GLN A CG  1 
ATOM   2085 C CD  . GLN B 2 262 ? 37.68715 -50.13432 19.01947  1.000 44.22756  ? 260 GLN A CD  1 
ATOM   2086 O OE1 . GLN B 2 262 ? 38.88194 -50.43335 19.09843  1.000 49.95756  ? 260 GLN A OE1 1 
ATOM   2087 N NE2 . GLN B 2 262 ? 36.88241 -50.62652 18.08286  1.000 50.46756  ? 260 GLN A NE2 1 
ATOM   2088 N N   . SER B 2 263 ? 38.51938 -48.53994 24.51668  1.000 32.19826  ? 261 SER A N   1 
ATOM   2089 C CA  . SER B 2 263 ? 38.75822 -48.94847 25.89473  1.000 30.28826  ? 261 SER A CA  1 
ATOM   2090 C C   . SER B 2 263 ? 37.88130 -48.20405 26.88736  1.000 31.34826  ? 261 SER A C   1 
ATOM   2091 O O   . SER B 2 263 ? 37.77741 -48.63410 28.04111  1.000 32.74826  ? 261 SER A O   1 
ATOM   2092 C CB  . SER B 2 263 ? 40.22849 -48.74173 26.27257  1.000 32.76826  ? 261 SER A CB  1 
ATOM   2093 O OG  . SER B 2 263 ? 40.45572 -47.43316 26.78158  1.000 31.68826  ? 261 SER A OG  1 
ATOM   2094 N N   . LEU B 2 264 ? 37.25772 -47.10392 26.47714  1.000 29.45456  ? 262 LEU A N   1 
ATOM   2095 C CA  . LEU B 2 264 ? 36.44796 -46.31375 27.39017  1.000 30.05456  ? 262 LEU A CA  1 
ATOM   2096 C C   . LEU B 2 264 ? 35.07521 -46.94556 27.57322  1.000 30.32456  ? 262 LEU A C   1 
ATOM   2097 O O   . LEU B 2 264 ? 34.47310 -47.44465 26.61690  1.000 29.85456  ? 262 LEU A O   1 
ATOM   2098 C CB  . LEU B 2 264 ? 36.29108 -44.88827 26.86496  1.000 30.77456  ? 262 LEU A CB  1 
ATOM   2099 C CG  . LEU B 2 264 ? 37.61819 -44.19059 26.56573  1.000 34.42456  ? 262 LEU A CG  1 
ATOM   2100 C CD1 . LEU B 2 264 ? 37.40013 -42.95512 25.72218  1.000 35.31456  ? 262 LEU A CD1 1 
ATOM   2101 C CD2 . LEU B 2 264 ? 38.33380 -43.84496 27.87540  1.000 32.87456  ? 262 LEU A CD2 1 
ATOM   2102 N N   . ALA B 2 265 ? 34.59589 -46.92168 28.81571  1.000 33.27682  ? 263 ALA A N   1 
ATOM   2103 C CA  . ALA B 2 265 ? 33.21202 -47.26160 29.11209  1.000 41.59682  ? 263 ALA A CA  1 
ATOM   2104 C C   . ALA B 2 265 ? 32.27828 -46.36826 28.30738  1.000 42.42682  ? 263 ALA A C   1 
ATOM   2105 O O   . ALA B 2 265 ? 32.45352 -45.14719 28.26801  1.000 37.66682  ? 263 ALA A O   1 
ATOM   2106 C CB  . ALA B 2 265 ? 32.94519 -47.09974 30.60766  1.000 43.08682  ? 263 ALA A CB  1 
ATOM   2107 N N   . GLN B 2 266 ? 31.31018 -46.98127 27.63154  1.000 41.09732  ? 264 GLN A N   1 
ATOM   2108 C CA  . GLN B 2 266 ? 30.43926 -46.22041 26.74754  1.000 44.25732  ? 264 GLN A CA  1 
ATOM   2109 C C   . GLN B 2 266 ? 29.50109 -45.33557 27.55726  1.000 45.70732  ? 264 GLN A C   1 
ATOM   2110 O O   . GLN B 2 266 ? 29.03371 -45.71446 28.63431  1.000 39.07732  ? 264 GLN A O   1 
ATOM   2111 C CB  . GLN B 2 266 ? 29.65851 -47.15830 25.83761  1.000 50.33732  ? 264 GLN A CB  1 
ATOM   2112 C CG  . GLN B 2 266 ? 30.54105 -47.78029 24.76975  1.000 61.96732  ? 264 GLN A CG  1 
ATOM   2113 C CD  . GLN B 2 266 ? 29.91735 -48.99434 24.10953  1.000 78.39732  ? 264 GLN A CD  1 
ATOM   2114 O OE1 . GLN B 2 266 ? 28.70252 -49.06463 23.92805  1.000 93.67732  ? 264 GLN A OE1 1 
ATOM   2115 N NE2 . GLN B 2 266 ? 30.75218 -49.96196 23.74708  1.000 86.63732  ? 264 GLN A NE2 1 
ATOM   2116 N N   . MET B 2 267 ? 29.27038 -44.12614 27.05267  1.000 43.89841  ? 265 MET A N   1 
ATOM   2117 C CA  . MET B 2 267 ? 28.46044 -43.14040 27.73686  1.000 40.80841  ? 265 MET A CA  1 
ATOM   2118 C C   . MET B 2 267 ? 27.47508 -42.53929 26.74895  1.000 31.85841  ? 265 MET A C   1 
ATOM   2119 O O   . MET B 2 267 ? 27.82907 -42.27317 25.59417  1.000 23.36841  ? 265 MET A O   1 
ATOM   2120 C CB  . MET B 2 267 ? 29.32083 -42.02476 28.33838  1.000 50.80841  ? 265 MET A CB  1 
ATOM   2121 C CG  . MET B 2 267 ? 30.19399 -42.44180 29.50724  1.000 58.06841  ? 265 MET A CG  1 
ATOM   2122 S SD  . MET B 2 267 ? 31.49002 -41.21314 29.78995  1.000 60.75841  ? 265 MET A SD  1 
ATOM   2123 C CE  . MET B 2 267 ? 32.89584 -42.03495 29.03367  1.000 71.31841  ? 265 MET A CE  1 
ATOM   2124 N N   . PRO B 2 268 ? 26.23361 -42.32710 27.15783  1.000 39.75076  ? 266 PRO A N   1 
ATOM   2125 C CA  . PRO B 2 268 ? 25.27601 -41.69518 26.25134  1.000 35.50076  ? 266 PRO A CA  1 
ATOM   2126 C C   . PRO B 2 268 ? 25.49309 -40.19214 26.21533  1.000 30.32076  ? 266 PRO A C   1 
ATOM   2127 O O   . PRO B 2 268 ? 26.02816 -39.59442 27.15279  1.000 28.13076  ? 266 PRO A O   1 
ATOM   2128 C CB  . PRO B 2 268 ? 23.92267 -42.05002 26.87479  1.000 35.78076  ? 266 PRO A CB  1 
ATOM   2129 C CG  . PRO B 2 268 ? 24.22753 -42.09914 28.35716  1.000 37.46076  ? 266 PRO A CG  1 
ATOM   2130 C CD  . PRO B 2 268 ? 25.64703 -42.61380 28.48221  1.000 38.95076  ? 266 PRO A CD  1 
ATOM   2131 N N   . LYS B 2 269 ? 25.09724 -39.59232 25.09358  1.000 24.65786  ? 267 LYS A N   1 
ATOM   2132 C CA  . LYS B 2 269 ? 24.91359 -38.14945 25.04173  1.000 27.87786  ? 267 LYS A CA  1 
ATOM   2133 C C   . LYS B 2 269 ? 23.97009 -37.71039 26.15631  1.000 26.03786  ? 267 LYS A C   1 
ATOM   2134 O O   . LYS B 2 269 ? 23.00042 -38.40187 26.47192  1.000 30.57786  ? 267 LYS A O   1 
ATOM   2135 C CB  . LYS B 2 269 ? 24.35502 -37.74632 23.67540  1.000 31.40786  ? 267 LYS A CB  1 
ATOM   2136 C CG  . LYS B 2 269 ? 24.10622 -36.26165 23.51535  1.000 37.19786  ? 267 LYS A CG  1 
ATOM   2137 C CD  . LYS B 2 269 ? 23.26230 -35.95832 22.30255  1.000 40.82786  ? 267 LYS A CD  1 
ATOM   2138 C CE  . LYS B 2 269 ? 22.71957 -34.54196 22.38432  1.000 47.59786  ? 267 LYS A CE  1 
ATOM   2139 N NZ  . LYS B 2 269 ? 21.87481 -34.34797 23.60509  1.000 49.60786  ? 267 LYS A NZ  1 
ATOM   2140 N N   . MET B 2 270 ? 24.28462 -36.58911 26.79447  1.000 25.52549  ? 268 MET A N   1 
ATOM   2141 C CA  . MET B 2 270 ? 23.39338 -36.02749 27.79741  1.000 24.38549  ? 268 MET A CA  1 
ATOM   2142 C C   . MET B 2 270 ? 22.34255 -35.14002 27.14213  1.000 23.67549  ? 268 MET A C   1 
ATOM   2143 O O   . MET B 2 270 ? 22.51623 -34.64042 26.02800  1.000 20.11549  ? 268 MET A O   1 
ATOM   2144 C CB  . MET B 2 270 ? 24.16870 -35.21280 28.83798  1.000 28.18549  ? 268 MET A CB  1 
ATOM   2145 C CG  . MET B 2 270 ? 25.00775 -36.05415 29.79254  1.000 34.77549  ? 268 MET A CG  1 
ATOM   2146 S SD  . MET B 2 270 ? 25.92810 -35.06015 30.99685  1.000 45.11549  ? 268 MET A SD  1 
ATOM   2147 C CE  . MET B 2 270 ? 24.59915 -34.44502 32.03666  1.000 42.28549  ? 268 MET A CE  1 
ATOM   2148 N N   . ASN B 2 271 ? 21.23789 -34.95826 27.85863  1.000 24.66729  ? 269 ASN A N   1 
ATOM   2149 C CA  . ASN B 2 271 ? 20.17827 -34.02099 27.49209  1.000 23.48729  ? 269 ASN A CA  1 
ATOM   2150 C C   . ASN B 2 271 ? 20.66086 -32.64050 27.90262  1.000 16.65729  ? 269 ASN A C   1 
ATOM   2151 O O   . ASN B 2 271 ? 20.83634 -32.38619 29.09340  1.000 17.63729  ? 269 ASN A O   1 
ATOM   2152 C CB  . ASN B 2 271 ? 18.88246 -34.41290 28.21531  1.000 26.64729  ? 269 ASN A CB  1 
ATOM   2153 C CG  . ASN B 2 271 ? 17.67777 -33.50193 27.89975  1.000 32.61729  ? 269 ASN A CG  1 
ATOM   2154 O OD1 . ASN B 2 271 ? 17.80170 -32.38826 27.37923  1.000 29.02729  ? 269 ASN A OD1 1 
ATOM   2155 N ND2 . ASN B 2 271 ? 16.49046 -33.98947 28.25428  1.000 31.76729  ? 269 ASN A ND2 1 
ATOM   2156 N N   . PHE B 2 272 ? 20.89174 -31.75215 26.92667  1.000 17.32678  ? 270 PHE A N   1 
ATOM   2157 C CA  . PHE B 2 272 ? 21.48610 -30.45278 27.24947  1.000 17.57678  ? 270 PHE A CA  1 
ATOM   2158 C C   . PHE B 2 272 ? 20.53150 -29.57772 28.04815  1.000 18.02678  ? 270 PHE A C   1 
ATOM   2159 O O   . PHE B 2 272 ? 20.98182 -28.73040 28.82775  1.000 16.83678  ? 270 PHE A O   1 
ATOM   2160 C CB  . PHE B 2 272 ? 21.89505 -29.68310 25.98844  1.000 17.34678  ? 270 PHE A CB  1 
ATOM   2161 C CG  . PHE B 2 272 ? 23.21957 -30.08295 25.39917  1.000 18.18678  ? 270 PHE A CG  1 
ATOM   2162 C CD1 . PHE B 2 272 ? 23.67782 -31.39116 25.45945  1.000 19.85678  ? 270 PHE A CD1 1 
ATOM   2163 C CD2 . PHE B 2 272 ? 24.00042 -29.13288 24.74359  1.000 18.65678  ? 270 PHE A CD2 1 
ATOM   2164 C CE1 . PHE B 2 272 ? 24.90715 -31.74586 24.88228  1.000 22.02678  ? 270 PHE A CE1 1 
ATOM   2165 C CE2 . PHE B 2 272 ? 25.21527 -29.47235 24.17467  1.000 21.20678  ? 270 PHE A CE2 1 
ATOM   2166 C CZ  . PHE B 2 272 ? 25.67053 -30.77777 24.23419  1.000 22.29678  ? 270 PHE A CZ  1 
ATOM   2167 N N   . ALA B 2 273 ? 19.21788 -29.74557 27.84552  1.000 15.38802  ? 271 ALA A N   1 
ATOM   2168 C CA  . ALA B 2 273 ? 18.24703 -28.90693 28.54180  1.000 20.02802  ? 271 ALA A CA  1 
ATOM   2169 C C   . ALA B 2 273 ? 18.31972 -29.09911 30.04919  1.000 21.88802  ? 271 ALA A C   1 
ATOM   2170 O O   . ALA B 2 273 ? 18.07768 -28.15120 30.80149  1.000 28.47802  ? 271 ALA A O   1 
ATOM   2171 C CB  . ALA B 2 273 ? 16.82916 -29.19470 28.03618  1.000 23.30802  ? 271 ALA A CB  1 
ATOM   2172 N N   . ASN B 2 274 ? 18.66374 -30.30525 30.50683  1.000 20.41854  ? 272 ASN A N   1 
ATOM   2173 C CA  . ASN B 2 274 ? 18.87726 -30.51842 31.93630  1.000 32.15854  ? 272 ASN A CA  1 
ATOM   2174 C C   . ASN B 2 274 ? 20.09578 -29.74277 32.42667  1.000 32.75854  ? 272 ASN A C   1 
ATOM   2175 O O   . ASN B 2 274 ? 20.07089 -29.16919 33.52193  1.000 41.81854  ? 272 ASN A O   1 
ATOM   2176 C CB  . ASN B 2 274 ? 19.05196 -32.01253 32.23547  1.000 37.97854  ? 272 ASN A CB  1 
ATOM   2177 C CG  . ASN B 2 274 ? 17.83275 -32.84727 31.85372  1.000 38.77854  ? 272 ASN A CG  1 
ATOM   2178 O OD1 . ASN B 2 274 ? 16.70316 -32.35512 31.82267  1.000 40.45854  ? 272 ASN A OD1 1 
ATOM   2179 N ND2 . ASN B 2 274 ? 18.06430 -34.12548 31.56479  1.000 37.10854  ? 272 ASN A ND2 1 
ATOM   2180 N N   . VAL B 2 275 ? 21.15795 -29.70709 31.61250  1.000 32.42598  ? 273 VAL A N   1 
ATOM   2181 C CA  . VAL B 2 275 ? 22.44068 -29.07808 31.93948  1.000 30.68598  ? 273 VAL A CA  1 
ATOM   2182 C C   . VAL B 2 275 ? 22.36019 -27.54472 31.94225  1.000 31.68598  ? 273 VAL A C   1 
ATOM   2183 O O   . VAL B 2 275 ? 23.19999 -26.88363 32.56731  1.000 22.56598  ? 273 VAL A O   1 
ATOM   2184 C CB  . VAL B 2 275 ? 23.49687 -29.59651 30.92452  1.000 31.48598  ? 273 VAL A CB  1 
ATOM   2185 C CG1 . VAL B 2 275 ? 24.91251 -29.15139 31.24285  1.000 36.83598  ? 273 VAL A CG1 1 
ATOM   2186 C CG2 . VAL B 2 275 ? 23.47311 -31.10406 30.83670  1.000 35.91598  ? 273 VAL A CG2 1 
ATOM   2187 N N   . PHE B 2 276 ? 21.36197 -26.95328 31.27760  1.000 31.80686  ? 274 PHE A N   1 
ATOM   2188 C CA  . PHE B 2 276 ? 21.28950 -25.50692 31.05672  1.000 24.36686  ? 274 PHE A CA  1 
ATOM   2189 C C   . PHE B 2 276 ? 19.89845 -24.95111 31.38238  1.000 26.79686  ? 274 PHE A C   1 
ATOM   2190 O O   . PHE B 2 276 ? 19.34087 -24.17320 30.60612  1.000 22.43686  ? 274 PHE A O   1 
ATOM   2191 C CB  . PHE B 2 276 ? 21.62793 -25.13258 29.60642  1.000 21.28686  ? 274 PHE A CB  1 
ATOM   2192 C CG  . PHE B 2 276 ? 23.05274 -25.39376 29.19953  1.000 21.33686  ? 274 PHE A CG  1 
ATOM   2193 C CD1 . PHE B 2 276 ? 24.03081 -24.42953 29.39169  1.000 23.46686  ? 274 PHE A CD1 1 
ATOM   2194 C CD2 . PHE B 2 276 ? 23.41217 -26.58835 28.58686  1.000 19.03686  ? 274 PHE A CD2 1 
ATOM   2195 C CE1 . PHE B 2 276 ? 25.34678 -24.66335 29.01028  1.000 19.84686  ? 274 PHE A CE1 1 
ATOM   2196 C CE2 . PHE B 2 276 ? 24.71454 -26.82997 28.20557  1.000 21.47686  ? 274 PHE A CE2 1 
ATOM   2197 C CZ  . PHE B 2 276 ? 25.68932 -25.85890 28.42055  1.000 22.38686  ? 274 PHE A CZ  1 
ATOM   2198 N N   . ILE B 2 277 ? 19.32530 -25.29985 32.54419  1.000 22.99205  ? 275 ILE A N   1 
ATOM   2199 C CA  . ILE B 2 277 ? 17.99656 -24.79892 32.90959  1.000 23.06205  ? 275 ILE A CA  1 
ATOM   2200 C C   . ILE B 2 277 ? 18.06407 -23.29644 33.13621  1.000 22.29205  ? 275 ILE A C   1 
ATOM   2201 O O   . ILE B 2 277 ? 18.99301 -22.79512 33.77977  1.000 23.31205  ? 275 ILE A O   1 
ATOM   2202 C CB  . ILE B 2 277 ? 17.45366 -25.53209 34.15503  1.000 29.29205  ? 275 ILE A CB  1 
ATOM   2203 C CG1 . ILE B 2 277 ? 17.05806 -26.97202 33.81431  1.000 37.83205  ? 275 ILE A CG1 1 
ATOM   2204 C CG2 . ILE B 2 277 ? 16.24065 -24.82619 34.75270  1.000 31.84205  ? 275 ILE A CG2 1 
ATOM   2205 C CD1 . ILE B 2 277 ? 15.79858 -27.08283 32.95968  1.000 43.49205  ? 275 ILE A CD1 1 
ATOM   2206 N N   . GLY B 2 278 ? 17.08600 -22.56492 32.59006  1.000 22.57291  ? 276 GLY A N   1 
ATOM   2207 C CA  . GLY B 2 278 ? 17.03300 -21.12731 32.69307  1.000 22.62291  ? 276 GLY A CA  1 
ATOM   2208 C C   . GLY B 2 278 ? 17.59633 -20.39683 31.49350  1.000 21.39291  ? 276 GLY A C   1 
ATOM   2209 O O   . GLY B 2 278 ? 17.30839 -19.20606 31.32127  1.000 25.52291  ? 276 GLY A O   1 
ATOM   2210 N N   . ALA B 2 279 ? 18.40217 -21.07113 30.67275  1.000 22.37030  ? 277 ALA A N   1 
ATOM   2211 C CA  . ALA B 2 279 ? 18.89964 -20.48702 29.43226  1.000 22.52030  ? 277 ALA A CA  1 
ATOM   2212 C C   . ALA B 2 279 ? 17.81996 -20.56335 28.35506  1.000 19.90030  ? 277 ALA A C   1 
ATOM   2213 O O   . ALA B 2 279 ? 17.00051 -21.48668 28.35481  1.000 18.72030  ? 277 ALA A O   1 
ATOM   2214 C CB  . ALA B 2 279 ? 20.15990 -21.21610 28.96679  1.000 24.16030  ? 277 ALA A CB  1 
ATOM   2215 N N   . ASN B 2 280 ? 17.79019 -19.53672 27.47133  1.000 19.18779  ? 278 ASN A N   1 
ATOM   2216 C CA  . ASN B 2 280 ? 16.97231 -19.48124 26.25160  1.000 17.61779  ? 278 ASN A CA  1 
ATOM   2217 C C   . ASN B 2 280 ? 16.97972 -20.85123 25.57798  1.000 15.08779  ? 278 ASN A C   1 
ATOM   2218 O O   . ASN B 2 280 ? 18.05918 -21.38277 25.26201  1.000 12.98779  ? 278 ASN A O   1 
ATOM   2219 C CB  . ASN B 2 280 ? 17.51197 -18.38497 25.31804  1.000 20.68779  ? 278 ASN A CB  1 
ATOM   2220 C CG  . ASN B 2 280 ? 16.56657 -18.03934 24.15524  1.000 21.98779  ? 278 ASN A CG  1 
ATOM   2221 O OD1 . ASN B 2 280 ? 15.79808 -18.86629 23.67404  1.000 21.06779  ? 278 ASN A OD1 1 
ATOM   2222 N ND2 . ASN B 2 280 ? 16.65979 -16.80154 23.68412  1.000 25.27779  ? 278 ASN A ND2 1 
ATOM   2223 N N   . PRO B 2 281 ? 15.81158 -21.49518 25.42777  1.000 14.51604  ? 279 PRO A N   1 
ATOM   2224 C CA  . PRO B 2 281 ? 15.78348 -22.81629 24.77827  1.000 14.69604  ? 279 PRO A CA  1 
ATOM   2225 C C   . PRO B 2 281 ? 16.31992 -22.80481 23.35633  1.000 11.37604  ? 279 PRO A C   1 
ATOM   2226 O O   . PRO B 2 281 ? 16.81000 -23.83237 22.88074  1.000 12.53604  ? 279 PRO A O   1 
ATOM   2227 C CB  . PRO B 2 281 ? 14.29555 -23.19413 24.80562  1.000 16.66604  ? 279 PRO A CB  1 
ATOM   2228 C CG  . PRO B 2 281 ? 13.57951 -21.92073 24.93255  1.000 18.65604  ? 279 PRO A CG  1 
ATOM   2229 C CD  . PRO B 2 281 ? 14.45545 -21.00188 25.73623  1.000 19.46604  ? 279 PRO A CD  1 
ATOM   2230 N N   . LEU B 2 282 ? 16.21693 -21.67745 22.65413  1.000 11.91107  ? 280 LEU A N   1 
ATOM   2231 C CA  . LEU B 2 282 ? 16.82482 -21.60246 21.33051  1.000 11.27107  ? 280 LEU A CA  1 
ATOM   2232 C C   . LEU B 2 282 ? 18.34698 -21.55759 21.43559  1.000 10.49107  ? 280 LEU A C   1 
ATOM   2233 O O   . LEU B 2 282 ? 19.04065 -22.11927 20.58342  1.000 11.84107  ? 280 LEU A O   1 
ATOM   2234 C CB  . LEU B 2 282 ? 16.28548 -20.38915 20.57944  1.000 11.77107  ? 280 LEU A CB  1 
ATOM   2235 C CG  . LEU B 2 282 ? 14.78657 -20.42966 20.22386  1.000 12.81107  ? 280 LEU A CG  1 
ATOM   2236 C CD1 . LEU B 2 282 ? 14.35218 -19.12146 19.55099  1.000 14.88107  ? 280 LEU A CD1 1 
ATOM   2237 C CD2 . LEU B 2 282 ? 14.48471 -21.62081 19.33465  1.000 13.00107  ? 280 LEU A CD2 1 
ATOM   2238 N N   . ALA B 2 283 ? 18.87255 -20.90081 22.47668  1.000 10.43121  ? 281 ALA A N   1 
ATOM   2239 C CA  . ALA B 2 283 ? 20.30839 -20.94161 22.75701  1.000 10.87121  ? 281 ALA A CA  1 
ATOM   2240 C C   . ALA B 2 283 ? 20.78631 -22.36576 23.01275  1.000 10.43121  ? 281 ALA A C   1 
ATOM   2241 O O   . ALA B 2 283 ? 21.79014 -22.80320 22.44389  1.000 10.36121  ? 281 ALA A O   1 
ATOM   2242 C CB  . ALA B 2 283 ? 20.63240 -20.04086 23.95451  1.000 12.33121  ? 281 ALA A CB  1 
ATOM   2243 N N   . VAL B 2 284 ? 20.07131 -23.11177 23.86530  1.000 9.67818   ? 282 VAL A N   1 
ATOM   2244 C CA  . VAL B 2 284 ? 20.46000 -24.48602 24.16936  1.000 10.54818  ? 282 VAL A CA  1 
ATOM   2245 C C   . VAL B 2 284 ? 20.37828 -25.36042 22.91844  1.000 10.58818  ? 282 VAL A C   1 
ATOM   2246 O O   . VAL B 2 284 ? 21.22094 -26.24616 22.70420  1.000 10.94818  ? 282 VAL A O   1 
ATOM   2247 C CB  . VAL B 2 284 ? 19.57670 -25.04369 25.30966  1.000 12.52818  ? 282 VAL A CB  1 
ATOM   2248 C CG1 . VAL B 2 284 ? 19.98358 -26.48134 25.65379  1.000 14.75818  ? 282 VAL A CG1 1 
ATOM   2249 C CG2 . VAL B 2 284 ? 19.64831 -24.13335 26.53982  1.000 14.65818  ? 282 VAL A CG2 1 
ATOM   2250 N N   . ASP B 2 285 ? 19.35093 -25.14031 22.08879  1.000 9.54470   ? 283 ASP A N   1 
ATOM   2251 C CA  . ASP B 2 285 ? 19.21062 -25.90235 20.84636  1.000 11.61470  ? 283 ASP A CA  1 
ATOM   2252 C C   . ASP B 2 285 ? 20.39208 -25.65436 19.91336  1.000 10.10470  ? 283 ASP A C   1 
ATOM   2253 O O   . ASP B 2 285 ? 20.95093 -26.59624 19.33728  1.000 12.34470  ? 283 ASP A O   1 
ATOM   2254 C CB  . ASP B 2 285 ? 17.90170 -25.52451 20.15070  1.000 13.55470  ? 283 ASP A CB  1 
ATOM   2255 C CG  . ASP B 2 285 ? 17.66576 -26.32631 18.87902  1.000 19.94470  ? 283 ASP A CG  1 
ATOM   2256 O OD1 . ASP B 2 285 ? 17.12210 -27.44644 18.97871  1.000 28.40470  ? 283 ASP A OD1 1 
ATOM   2257 O OD2 . ASP B 2 285 ? 18.04372 -25.84585 17.78231  1.000 21.74470  ? 283 ASP A OD2 1 
ATOM   2258 N N   . LEU B 2 286 ? 20.80666 -24.39361 19.78176  1.000 10.27433  ? 284 LEU A N   1 
ATOM   2259 C CA  . LEU B 2 286 ? 21.98960 -24.09398 18.97901  1.000 10.98433  ? 284 LEU A CA  1 
ATOM   2260 C C   . LEU B 2 286 ? 23.24280 -24.73892 19.57007  1.000 11.10433  ? 284 LEU A C   1 
ATOM   2261 O O   . LEU B 2 286 ? 24.06674 -25.29119 18.83137  1.000 8.85433   ? 284 LEU A O   1 
ATOM   2262 C CB  . LEU B 2 286 ? 22.15838 -22.58275 18.84875  1.000 10.44433  ? 284 LEU A CB  1 
ATOM   2263 C CG  . LEU B 2 286 ? 23.33704 -22.09484 17.99966  1.000 11.67433  ? 284 LEU A CG  1 
ATOM   2264 C CD1 . LEU B 2 286 ? 23.26012 -22.62618 16.55897  1.000 12.53433  ? 284 LEU A CD1 1 
ATOM   2265 C CD2 . LEU B 2 286 ? 23.31262 -20.59134 18.00181  1.000 11.66433  ? 284 LEU A CD2 1 
ATOM   2266 N N   . LEU B 2 287 ? 23.37838 -24.73372 20.90470  1.000 10.67100  ? 285 LEU A N   1 
ATOM   2267 C CA  . LEU B 2 287 ? 24.54604 -25.35947 21.52826  1.000 11.60100  ? 285 LEU A CA  1 
ATOM   2268 C C   . LEU B 2 287 ? 24.63029 -26.84157 21.21021  1.000 10.82100  ? 285 LEU A C   1 
ATOM   2269 O O   . LEU B 2 287 ? 25.72312 -27.36642 20.94093  1.000 11.75100  ? 285 LEU A O   1 
ATOM   2270 C CB  . LEU B 2 287 ? 24.50747 -25.16369 23.04187  1.000 14.52100  ? 285 LEU A CB  1 
ATOM   2271 C CG  . LEU B 2 287 ? 25.09338 -23.85984 23.53117  1.000 19.57100  ? 285 LEU A CG  1 
ATOM   2272 C CD1 . LEU B 2 287 ? 24.80423 -23.69872 25.02554  1.000 24.28100  ? 285 LEU A CD1 1 
ATOM   2273 C CD2 . LEU B 2 287 ? 26.58414 -23.91804 23.28094  1.000 19.52100  ? 285 LEU A CD2 1 
ATOM   2274 N N   . GLU B 2 288 ? 23.48413 -27.53217 21.23343  1.000 10.36134  ? 286 GLU A N   1 
ATOM   2275 C CA  . GLU B 2 288 ? 23.44771 -28.95778 20.91554  1.000 13.94134  ? 286 GLU A CA  1 
ATOM   2276 C C   . GLU B 2 288 ? 23.87800 -29.21916 19.47644  1.000 14.20134  ? 286 GLU A C   1 
ATOM   2277 O O   . GLU B 2 288 ? 24.47986 -30.25804 19.18094  1.000 15.21134  ? 286 GLU A O   1 
ATOM   2278 C CB  . GLU B 2 288 ? 22.03283 -29.49612 21.15784  1.000 20.34134  ? 286 GLU A CB  1 
ATOM   2279 C CG  . GLU B 2 288 ? 21.95285 -30.82578 21.90297  1.000 32.73134  ? 286 GLU A CG  1 
ATOM   2280 C CD  . GLU B 2 288 ? 20.66299 -30.94704 22.70201  1.000 42.79134  ? 286 GLU A CD  1 
ATOM   2281 O OE1 . GLU B 2 288 ? 19.78099 -30.06760 22.53122  1.000 45.32134  ? 286 GLU A OE1 1 
ATOM   2282 O OE2 . GLU B 2 288 ? 20.53432 -31.90242 23.50943  1.000 46.95134  ? 286 GLU A OE2 1 
ATOM   2283 N N   . LYS B 2 289 ? 23.62049 -28.27213 18.57809  1.000 12.72085  ? 287 LYS A N   1 
ATOM   2284 C CA  . LYS B 2 289 ? 24.03374 -28.41345 17.19207  1.000 11.94085  ? 287 LYS A CA  1 
ATOM   2285 C C   . LYS B 2 289 ? 25.50539 -28.07448 16.96936  1.000 12.08085  ? 287 LYS A C   1 
ATOM   2286 O O   . LYS B 2 289 ? 26.09330 -28.55466 15.99453  1.000 9.96085   ? 287 LYS A O   1 
ATOM   2287 C CB  . LYS B 2 289 ? 23.13792 -27.53949 16.32603  1.000 12.22085  ? 287 LYS A CB  1 
ATOM   2288 C CG  . LYS B 2 289 ? 21.74829 -28.12028 16.26807  1.000 14.48085  ? 287 LYS A CG  1 
ATOM   2289 C CD  . LYS B 2 289 ? 20.76363 -27.16094 15.68126  1.000 19.25085  ? 287 LYS A CD  1 
ATOM   2290 C CE  . LYS B 2 289 ? 19.54303 -27.95032 15.21723  1.000 23.34085  ? 287 LYS A CE  1 
ATOM   2291 N NZ  . LYS B 2 289 ? 19.04599 -28.85424 16.30332  1.000 25.70085  ? 287 LYS A NZ  1 
ATOM   2292 N N   . MET B 2 290 ? 26.11559 -27.28066 17.85356  1.000 11.21932  ? 288 MET A N   1 
ATOM   2293 C CA  . MET B 2 290 ? 27.52803 -26.96086 17.70238  1.000 12.65932  ? 288 MET A CA  1 
ATOM   2294 C C   . MET B 2 290 ? 28.43548 -27.98494 18.37277  1.000 11.35932  ? 288 MET A C   1 
ATOM   2295 O O   . MET B 2 290 ? 29.53610 -28.26316 17.88352  1.000 10.31932  ? 288 MET A O   1 
ATOM   2296 C CB  . MET B 2 290 ? 27.80539 -25.57039 18.27899  1.000 12.58932  ? 288 MET A CB  1 
ATOM   2297 C CG  . MET B 2 290 ? 27.11287 -24.45657 17.52153  1.000 15.24932  ? 288 MET A CG  1 
ATOM   2298 S SD  . MET B 2 290 ? 27.47326 -22.87462 18.31183  1.000 21.59932  ? 288 MET A SD  1 
ATOM   2299 C CE  . MET B 2 290 ? 26.88015 -21.74030 17.09911  1.000 23.00932  ? 288 MET A CE  1 
ATOM   2300 N N   . LEU B 2 291 ? 28.01322 -28.52032 19.50624  1.000 12.63188  ? 289 LEU A N   1 
ATOM   2301 C CA  . LEU B 2 291 ? 28.83548 -29.45265 20.27539  1.000 13.67188  ? 289 LEU A CA  1 
ATOM   2302 C C   . LEU B 2 291 ? 28.48011 -30.89981 19.95865  1.000 15.91188  ? 289 LEU A C   1 
ATOM   2303 O O   . LEU B 2 291 ? 28.23763 -31.70656 20.84260  1.000 15.88188  ? 289 LEU A O   1 
ATOM   2304 C CB  . LEU B 2 291 ? 28.68264 -29.16364 21.75850  1.000 12.93188  ? 289 LEU A CB  1 
ATOM   2305 C CG  . LEU B 2 291 ? 29.12181 -27.75254 22.15860  1.000 13.17188  ? 289 LEU A CG  1 
ATOM   2306 C CD1 . LEU B 2 291 ? 28.71411 -27.48046 23.58393  1.000 13.89188  ? 289 LEU A CD1 1 
ATOM   2307 C CD2 . LEU B 2 291 ? 30.63444 -27.62345 22.00825  1.000 12.50188  ? 289 LEU A CD2 1 
ATOM   2308 N N   . VAL B 2 292 ? 28.42742 -31.22631 18.70339  1.000 17.98813  ? 290 VAL A N   1 
ATOM   2309 C CA  . VAL B 2 292 ? 28.29075 -32.60068 18.24512  1.000 20.23813  ? 290 VAL A CA  1 
ATOM   2310 C C   . VAL B 2 292 ? 29.68685 -33.17770 18.10693  1.000 19.37813  ? 290 VAL A C   1 
ATOM   2311 O O   . VAL B 2 292 ? 30.58535 -32.51775 17.57790  1.000 15.86813  ? 290 VAL A O   1 
ATOM   2312 C CB  . VAL B 2 292 ? 27.53100 -32.65938 16.90748  1.000 24.85813  ? 290 VAL A CB  1 
ATOM   2313 C CG1 . VAL B 2 292 ? 27.28076 -34.09289 16.50504  1.000 28.26813  ? 290 VAL A CG1 1 
ATOM   2314 C CG2 . VAL B 2 292 ? 26.21889 -31.89826 17.00202  1.000 25.07813  ? 290 VAL A CG2 1 
ATOM   2315 N N   . LEU B 2 293 ? 29.87979 -34.41671 18.57798  1.000 21.12666  ? 291 LEU A N   1 
ATOM   2316 C CA  . LEU B 2 293 ? 31.21991 -34.99941 18.59609  1.000 21.05666  ? 291 LEU A CA  1 
ATOM   2317 C C   . LEU B 2 293 ? 31.73312 -35.28274 17.18973  1.000 22.97666  ? 291 LEU A C   1 
ATOM   2318 O O   . LEU B 2 293 ? 32.91867 -35.08012 16.90520  1.000 21.81666  ? 291 LEU A O   1 
ATOM   2319 C CB  . LEU B 2 293 ? 31.21540 -36.27763 19.43262  1.000 25.90666  ? 291 LEU A CB  1 
ATOM   2320 C CG  . LEU B 2 293 ? 32.56784 -36.89467 19.76491  1.000 27.08666  ? 291 LEU A CG  1 
ATOM   2321 C CD1 . LEU B 2 293 ? 33.35899 -35.99094 20.66750  1.000 26.93666  ? 291 LEU A CD1 1 
ATOM   2322 C CD2 . LEU B 2 293 ? 32.32222 -38.24091 20.42897  1.000 33.92666  ? 291 LEU A CD2 1 
ATOM   2323 N N   . ASP B 2 294 ? 30.86373 -35.75911 16.30065  1.000 24.50587  ? 292 ASP A N   1 
ATOM   2324 C CA  . ASP B 2 294 ? 31.23704 -35.96463 14.90940  1.000 26.07587  ? 292 ASP A CA  1 
ATOM   2325 C C   . ASP B 2 294 ? 31.23915 -34.61091 14.21173  1.000 24.64587  ? 292 ASP A C   1 
ATOM   2326 O O   . ASP B 2 294 ? 30.19292 -33.96275 14.09778  1.000 25.17587  ? 292 ASP A O   1 
ATOM   2327 C CB  . ASP B 2 294 ? 30.27356 -36.93630 14.22611  1.000 27.64587  ? 292 ASP A CB  1 
ATOM   2328 C CG  . ASP B 2 294 ? 30.81413 -37.49237 12.90217  1.000 34.76587  ? 292 ASP A CG  1 
ATOM   2329 O OD1 . ASP B 2 294 ? 31.58150 -36.79650 12.18537  1.000 34.57587  ? 292 ASP A OD1 1 
ATOM   2330 O OD2 . ASP B 2 294 ? 30.45508 -38.64583 12.56743  1.000 38.48587  ? 292 ASP A OD2 1 
ATOM   2331 N N   . SER B 2 295 ? 32.41460 -34.19542 13.74344  1.000 24.92990  ? 293 SER A N   1 
ATOM   2332 C CA  . SER B 2 295 ? 32.55729 -32.88043 13.13396  1.000 25.40990  ? 293 SER A CA  1 
ATOM   2333 C C   . SER B 2 295 ? 31.72588 -32.74351 11.86229  1.000 25.78990  ? 293 SER A C   1 
ATOM   2334 O O   . SER B 2 295 ? 31.24659 -31.64720 11.55802  1.000 25.32990  ? 293 SER A O   1 
ATOM   2335 C CB  . SER B 2 295 ? 34.03453 -32.60874 12.84791  1.000 23.19990  ? 293 SER A CB  1 
ATOM   2336 O OG  . SER B 2 295 ? 34.50608 -33.45955 11.81773  1.000 29.55990  ? 293 SER A OG  1 
ATOM   2337 N N   . ASP B 2 296 ? 31.50807 -33.84169 11.12761  1.000 24.11391  ? 294 ASP A N   1 
ATOM   2338 C CA  . ASP B 2 296 ? 30.69797 -33.78396 9.91477   1.000 26.07391  ? 294 ASP A CA  1 
ATOM   2339 C C   . ASP B 2 296 ? 29.21970 -33.52726 10.19675  1.000 22.85391  ? 294 ASP A C   1 
ATOM   2340 O O   . ASP B 2 296 ? 28.48173 -33.17605 9.27150   1.000 19.58391  ? 294 ASP A O   1 
ATOM   2341 C CB  . ASP B 2 296 ? 30.84199 -35.08247 9.12020   1.000 31.72391  ? 294 ASP A CB  1 
ATOM   2342 C CG  . ASP B 2 296 ? 32.25125 -35.29324 8.59573   1.000 40.67391  ? 294 ASP A CG  1 
ATOM   2343 O OD1 . ASP B 2 296 ? 32.84438 -34.33600 8.04626   1.000 43.35391  ? 294 ASP A OD1 1 
ATOM   2344 O OD2 . ASP B 2 296 ? 32.76854 -36.42077 8.74628   1.000 53.42391  ? 294 ASP A OD2 1 
ATOM   2345 N N   . LYS B 2 297 ? 28.77019 -33.71012 11.43478  1.000 18.56968  ? 295 LYS A N   1 
ATOM   2346 C CA  . LYS B 2 297 ? 27.38688 -33.44077 11.81769  1.000 19.97968  ? 295 LYS A CA  1 
ATOM   2347 C C   . LYS B 2 297 ? 27.21937 -32.11149 12.53552  1.000 17.35968  ? 295 LYS A C   1 
ATOM   2348 O O   . LYS B 2 297 ? 26.08954 -31.75113 12.87756  1.000 15.62968  ? 295 LYS A O   1 
ATOM   2349 C CB  . LYS B 2 297 ? 26.84894 -34.55441 12.72190  1.000 24.14968  ? 295 LYS A CB  1 
ATOM   2350 C CG  . LYS B 2 297 ? 27.10762 -35.96099 12.23587  1.000 28.32968  ? 295 LYS A CG  1 
ATOM   2351 C CD  . LYS B 2 297 ? 26.50402 -36.19868 10.88615  1.000 33.77968  ? 295 LYS A CD  1 
ATOM   2352 C CE  . LYS B 2 297 ? 26.78671 -37.61289 10.40546  1.000 42.36968  ? 295 LYS A CE  1 
ATOM   2353 N NZ  . LYS B 2 297 ? 26.45081 -37.75980 8.96005   1.000 49.22968  ? 295 LYS A NZ  1 
ATOM   2354 N N   . ARG B 2 298 ? 28.31028 -31.39818 12.82149  1.000 15.00868  ? 296 ARG A N   1 
ATOM   2355 C CA  . ARG B 2 298 ? 28.17991 -30.08275 13.43357  1.000 14.75868  ? 296 ARG A CA  1 
ATOM   2356 C C   . ARG B 2 298 ? 27.50656 -29.11543 12.47205  1.000 12.42868  ? 296 ARG A C   1 
ATOM   2357 O O   . ARG B 2 298 ? 27.65356 -29.21605 11.24922  1.000 13.75868  ? 296 ARG A O   1 
ATOM   2358 C CB  . ARG B 2 298 ? 29.54961 -29.52476 13.83757  1.000 17.34868  ? 296 ARG A CB  1 
ATOM   2359 C CG  . ARG B 2 298 ? 30.06067 -30.04825 15.14001  1.000 20.75868  ? 296 ARG A CG  1 
ATOM   2360 C CD  . ARG B 2 298 ? 31.52019 -29.66284 15.38067  1.000 19.58868  ? 296 ARG A CD  1 
ATOM   2361 N NE  . ARG B 2 298 ? 32.14488 -30.69798 16.19207  1.000 17.75868  ? 296 ARG A NE  1 
ATOM   2362 C CZ  . ARG B 2 298 ? 33.44241 -30.96379 16.21384  1.000 20.23868  ? 296 ARG A CZ  1 
ATOM   2363 N NH1 . ARG B 2 298 ? 34.31349 -30.22290 15.53945  1.000 19.02868  ? 296 ARG A NH1 1 
ATOM   2364 N NH2 . ARG B 2 298 ? 33.87494 -32.01070 16.91619  1.000 19.81868  ? 296 ARG A NH2 1 
ATOM   2365 N N   . ILE B 2 299 ? 26.77599 -28.15355 13.03589  1.000 10.56534  ? 297 ILE A N   1 
ATOM   2366 C CA  . ILE B 2 299 ? 26.22679 -27.07433 12.22447  1.000 10.82534  ? 297 ILE A CA  1 
ATOM   2367 C C   . ILE B 2 299 ? 27.36823 -26.22693 11.64254  1.000 10.78534  ? 297 ILE A C   1 
ATOM   2368 O O   . ILE B 2 299 ? 28.42032 -26.06479 12.26247  1.000 10.55534  ? 297 ILE A O   1 
ATOM   2369 C CB  . ILE B 2 299 ? 25.24853 -26.25923 13.08853  1.000 9.78534   ? 297 ILE A CB  1 
ATOM   2370 C CG1 . ILE B 2 299 ? 24.35623 -25.36474 12.24459  1.000 10.21534  ? 297 ILE A CG1 1 
ATOM   2371 C CG2 . ILE B 2 299 ? 25.97200 -25.46751 14.18036  1.000 9.97534   ? 297 ILE A CG2 1 
ATOM   2372 C CD1 . ILE B 2 299 ? 23.15620 -24.87190 13.02204  1.000 11.34534  ? 297 ILE A CD1 1 
ATOM   2373 N N   . THR B 2 300 ? 27.19330 -25.73625 10.41756  1.000 10.56627  ? 298 THR A N   1 
ATOM   2374 C CA  . THR B 2 300 ? 28.17793 -24.82664 9.84231   1.000 11.06627  ? 298 THR A CA  1 
ATOM   2375 C C   . THR B 2 300 ? 27.87063 -23.38891 10.26226  1.000 10.10627  ? 298 THR A C   1 
ATOM   2376 O O   . THR B 2 300 ? 26.76854 -23.07320 10.71869  1.000 9.97627   ? 298 THR A O   1 
ATOM   2377 C CB  . THR B 2 300 ? 28.21162 -24.91942 8.30854   1.000 11.76627  ? 298 THR A CB  1 
ATOM   2378 O OG1 . THR B 2 300 ? 26.99885 -24.38317 7.77466   1.000 11.76627  ? 298 THR A OG1 1 
ATOM   2379 C CG2 . THR B 2 300 ? 28.37962 -26.35460 7.82760   1.000 12.77627  ? 298 THR A CG2 1 
ATOM   2380 N N   . ALA B 2 301 ? 28.85874 -22.49953 10.07337  1.000 7.94739   ? 299 ALA A N   1 
ATOM   2381 C CA  . ALA B 2 301 ? 28.64862 -21.08296 10.38307  1.000 8.49739   ? 299 ALA A CA  1 
ATOM   2382 C C   . ALA B 2 301 ? 27.49204 -20.49500 9.56994   1.000 9.37739   ? 299 ALA A C   1 
ATOM   2383 O O   . ALA B 2 301 ? 26.64406 -19.78098 10.12172  1.000 9.93739   ? 299 ALA A O   1 
ATOM   2384 C CB  . ALA B 2 301 ? 29.94383 -20.28169 10.15644  1.000 8.38739   ? 299 ALA A CB  1 
ATOM   2385 N N   . ALA B 2 302 ? 27.41355 -20.81913 8.26713   1.000 9.33806   ? 300 ALA A N   1 
ATOM   2386 C CA  . ALA B 2 302 ? 26.30774 -20.32474 7.44532   1.000 10.91806  ? 300 ALA A CA  1 
ATOM   2387 C C   . ALA B 2 302 ? 24.95180 -20.83266 7.94600   1.000 11.32806  ? 300 ALA A C   1 
ATOM   2388 O O   . ALA B 2 302 ? 23.99482 -20.05836 8.05341   1.000 12.60806  ? 300 ALA A O   1 
ATOM   2389 C CB  . ALA B 2 302 ? 26.50996 -20.71988 5.98215   1.000 11.65806  ? 300 ALA A CB  1 
ATOM   2390 N N   . GLN B 2 303 ? 24.85017 -22.13706 8.23927   1.000 12.01467  ? 301 GLN A N   1 
ATOM   2391 C CA  . GLN B 2 303 ? 23.60764 -22.69988 8.77451   1.000 11.72467  ? 301 GLN A CA  1 
ATOM   2392 C C   . GLN B 2 303 ? 23.24803 -22.10325 10.13378  1.000 9.78467   ? 301 GLN A C   1 
ATOM   2393 O O   . GLN B 2 303 ? 22.07648 -21.80306 10.39675  1.000 9.74467   ? 301 GLN A O   1 
ATOM   2394 C CB  . GLN B 2 303 ? 23.73408 -24.22315 8.88744   1.000 15.05467  ? 301 GLN A CB  1 
ATOM   2395 C CG  . GLN B 2 303 ? 23.83933 -24.96798 7.55868   1.000 18.65467  ? 301 GLN A CG  1 
ATOM   2396 C CD  . GLN B 2 303 ? 24.43834 -26.38041 7.69825   1.000 21.55467  ? 301 GLN A CD  1 
ATOM   2397 O OE1 . GLN B 2 303 ? 24.93895 -26.76875 8.75686   1.000 14.92467  ? 301 GLN A OE1 1 
ATOM   2398 N NE2 . GLN B 2 303 ? 24.39732 -27.14415 6.60982   1.000 25.69467  ? 301 GLN A NE2 1 
ATOM   2399 N N   . ALA B 2 304 ? 24.24355 -21.93016 11.01594  1.000 8.56777   ? 302 ALA A N   1 
ATOM   2400 C CA  . ALA B 2 304 ? 24.00014 -21.35166 12.33533  1.000 8.34777   ? 302 ALA A CA  1 
ATOM   2401 C C   . ALA B 2 304 ? 23.42980 -19.93426 12.26720  1.000 8.38777   ? 302 ALA A C   1 
ATOM   2402 O O   . ALA B 2 304 ? 22.60419 -19.56759 13.10701  1.000 7.68777   ? 302 ALA A O   1 
ATOM   2403 C CB  . ALA B 2 304 ? 25.30083 -21.36763 13.14988  1.000 8.23777   ? 302 ALA A CB  1 
ATOM   2404 N N   . LEU B 2 305 ? 23.83659 -19.12379 11.27989  1.000 8.74539   ? 303 LEU A N   1 
ATOM   2405 C CA  . LEU B 2 305 ? 23.29675 -17.76317 11.17406  1.000 9.52539   ? 303 LEU A CA  1 
ATOM   2406 C C   . LEU B 2 305 ? 21.79730 -17.76132 10.89181  1.000 9.31539   ? 303 LEU A C   1 
ATOM   2407 O O   . LEU B 2 305 ? 21.09836 -16.81063 11.26395  1.000 10.42539  ? 303 LEU A O   1 
ATOM   2408 C CB  . LEU B 2 305 ? 24.03408 -16.98118 10.08545  1.000 9.93539   ? 303 LEU A CB  1 
ATOM   2409 C CG  . LEU B 2 305 ? 25.50476 -16.65565 10.37523  1.000 10.83539  ? 303 LEU A CG  1 
ATOM   2410 C CD1 . LEU B 2 305 ? 26.20175 -16.16298 9.11126   1.000 11.94539  ? 303 LEU A CD1 1 
ATOM   2411 C CD2 . LEU B 2 305 ? 25.63565 -15.60745 11.48620  1.000 11.41539  ? 303 LEU A CD2 1 
ATOM   2412 N N   . ALA B 2 306 ? 21.28793 -18.81536 10.25336  1.000 12.21915  ? 304 ALA A N   1 
ATOM   2413 C CA  . ALA B 2 306 ? 19.86032 -18.98864 9.99088   1.000 14.76915  ? 304 ALA A CA  1 
ATOM   2414 C C   . ALA B 2 306 ? 19.08433 -19.59275 11.15875  1.000 14.05915  ? 304 ALA A C   1 
ATOM   2415 O O   . ALA B 2 306 ? 17.86158 -19.75944 11.04324  1.000 14.34915  ? 304 ALA A O   1 
ATOM   2416 C CB  . ALA B 2 306 ? 19.65573 -19.88508 8.76381   1.000 15.96915  ? 304 ALA A CB  1 
ATOM   2417 N N   . HIS B 2 307 ? 19.75381 -19.95469 12.25305  1.000 13.18529  ? 305 HIS A N   1 
ATOM   2418 C CA  . HIS B 2 307 ? 19.06236 -20.50736 13.41647  1.000 12.26529  ? 305 HIS A CA  1 
ATOM   2419 C C   . HIS B 2 307 ? 18.21107 -19.42272 14.07589  1.000 11.65529  ? 305 HIS A C   1 
ATOM   2420 O O   . HIS B 2 307 ? 18.62105 -18.26024 14.16256  1.000 10.97529  ? 305 HIS A O   1 
ATOM   2421 C CB  . HIS B 2 307 ? 20.09280 -21.07416 14.39995  1.000 11.76529  ? 305 HIS A CB  1 
ATOM   2422 C CG  . HIS B 2 307 ? 19.50966 -21.88668 15.51923  1.000 11.30529  ? 305 HIS A CG  1 
ATOM   2423 N ND1 . HIS B 2 307 ? 18.79574 -21.32464 16.55235  1.000 10.52529  ? 305 HIS A ND1 1 
ATOM   2424 C CD2 . HIS B 2 307 ? 19.56652 -23.21432 15.78242  1.000 12.44529  ? 305 HIS A CD2 1 
ATOM   2425 C CE1 . HIS B 2 307 ? 18.41818 -22.27135 17.39509  1.000 11.65529  ? 305 HIS A CE1 1 
ATOM   2426 N NE2 . HIS B 2 307 ? 18.87013 -23.42946 16.95006  1.000 11.19529  ? 305 HIS A NE2 1 
ATOM   2427 N N   . ALA B 2 308 ? 17.01861 -19.81189 14.55800  1.000 11.34598  ? 306 ALA A N   1 
ATOM   2428 C CA  . ALA B 2 308 ? 16.05295 -18.86083 15.10832  1.000 11.69598  ? 306 ALA A CA  1 
ATOM   2429 C C   . ALA B 2 308 ? 16.58523 -18.08293 16.30004  1.000 11.76598  ? 306 ALA A C   1 
ATOM   2430 O O   . ALA B 2 308 ? 16.07148 -17.00457 16.58244  1.000 12.76598  ? 306 ALA A O   1 
ATOM   2431 C CB  . ALA B 2 308 ? 14.76123 -19.57713 15.52850  1.000 14.33598  ? 306 ALA A CB  1 
ATOM   2432 N N   . TYR B 2 309 ? 17.62046 -18.58132 16.98058  1.000 10.79514  ? 307 TYR A N   1 
ATOM   2433 C CA  . TYR B 2 309 ? 18.26427 -17.81852 18.05551  1.000 11.67514  ? 307 TYR A CA  1 
ATOM   2434 C C   . TYR B 2 309 ? 18.70010 -16.42391 17.60609  1.000 11.57514  ? 307 TYR A C   1 
ATOM   2435 O O   . TYR B 2 309 ? 18.62296 -15.47087 18.39034  1.000 9.71514   ? 307 TYR A O   1 
ATOM   2436 C CB  . TYR B 2 309 ? 19.45484 -18.61382 18.59459  1.000 12.14514  ? 307 TYR A CB  1 
ATOM   2437 C CG  . TYR B 2 309 ? 20.15199 -17.97250 19.77773  1.000 14.18514  ? 307 TYR A CG  1 
ATOM   2438 C CD1 . TYR B 2 309 ? 19.44980 -17.67510 20.94203  1.000 14.10514  ? 307 TYR A CD1 1 
ATOM   2439 C CD2 . TYR B 2 309 ? 21.52160 -17.69304 19.74209  1.000 15.00514  ? 307 TYR A CD2 1 
ATOM   2440 C CE1 . TYR B 2 309 ? 20.08023 -17.09215 22.03999  1.000 15.85514  ? 307 TYR A CE1 1 
ATOM   2441 C CE2 . TYR B 2 309 ? 22.16153 -17.10681 20.83614  1.000 15.61514  ? 307 TYR A CE2 1 
ATOM   2442 C CZ  . TYR B 2 309 ? 21.43505 -16.82383 21.98626  1.000 18.34514  ? 307 TYR A CZ  1 
ATOM   2443 O OH  . TYR B 2 309 ? 22.04390 -16.23942 23.08533  1.000 22.49514  ? 307 TYR A OH  1 
ATOM   2444 N N   . PHE B 2 310 ? 19.06576 -16.26125 16.32681  1.000 11.73363  ? 308 PHE A N   1 
ATOM   2445 C CA  . PHE B 2 310 ? 19.55617 -14.98994 15.80928  1.000 12.40363  ? 308 PHE A CA  1 
ATOM   2446 C C   . PHE B 2 310 ? 18.53134 -14.23644 14.98021  1.000 15.37363  ? 308 PHE A C   1 
ATOM   2447 O O   . PHE B 2 310 ? 18.92281 -13.35546 14.20786  1.000 16.06363  ? 308 PHE A O   1 
ATOM   2448 C CB  . PHE B 2 310 ? 20.80847 -15.19429 14.94934  1.000 11.00363  ? 308 PHE A CB  1 
ATOM   2449 C CG  . PHE B 2 310 ? 21.91005 -15.87761 15.66662  1.000 9.63363   ? 308 PHE A CG  1 
ATOM   2450 C CD1 . PHE B 2 310 ? 22.49461 -15.28367 16.77275  1.000 9.05363   ? 308 PHE A CD1 1 
ATOM   2451 C CD2 . PHE B 2 310 ? 22.35029 -17.11192 15.24894  1.000 8.97363   ? 308 PHE A CD2 1 
ATOM   2452 C CE1 . PHE B 2 310 ? 23.51109 -15.91440 17.46058  1.000 8.55363   ? 308 PHE A CE1 1 
ATOM   2453 C CE2 . PHE B 2 310 ? 23.35397 -17.75452 15.93112  1.000 8.91363   ? 308 PHE A CE2 1 
ATOM   2454 C CZ  . PHE B 2 310 ? 23.94809 -17.14581 17.05033  1.000 8.48363   ? 308 PHE A CZ  1 
ATOM   2455 N N   . ALA B 2 311 ? 17.23749 -14.54706 15.12898  1.000 15.79762  ? 309 ALA A N   1 
ATOM   2456 C CA  . ALA B 2 311 ? 16.22650 -13.96408 14.24756  1.000 18.93762  ? 309 ALA A CA  1 
ATOM   2457 C C   . ALA B 2 311 ? 16.22447 -12.43902 14.28746  1.000 17.82762  ? 309 ALA A C   1 
ATOM   2458 O O   . ALA B 2 311 ? 15.92891 -11.79914 13.27526  1.000 22.26762  ? 309 ALA A O   1 
ATOM   2459 C CB  . ALA B 2 311 ? 14.84158 -14.50250 14.59820  1.000 21.50762  ? 309 ALA A CB  1 
ATOM   2460 N N   . GLN B 2 312 ? 16.61399 -11.82854 15.40361  1.000 17.16380  ? 310 GLN A N   1 
ATOM   2461 C CA  . GLN B 2 312 ? 16.60278 -10.37084 15.39048  1.000 20.82380  ? 310 GLN A CA  1 
ATOM   2462 C C   . GLN B 2 312 ? 17.83057 -9.76462  14.71583  1.000 18.56380  ? 310 GLN A C   1 
ATOM   2463 O O   . GLN B 2 312 ? 17.81909 -8.56605  14.42079  1.000 22.31380  ? 310 GLN A O   1 
ATOM   2464 C CB  . GLN B 2 312 ? 16.45665 -9.81290  16.80841  1.000 29.35380  ? 310 GLN A CB  1 
ATOM   2465 C CG  . GLN B 2 312 ? 17.64999 -9.99007  17.70673  1.000 34.43380  ? 310 GLN A CG  1 
ATOM   2466 C CD  . GLN B 2 312 ? 17.53888 -9.16667  18.97640  1.000 42.71380  ? 310 GLN A CD  1 
ATOM   2467 O OE1 . GLN B 2 312 ? 17.08765 -8.02062  18.94530  1.000 52.63380  ? 310 GLN A OE1 1 
ATOM   2468 N NE2 . GLN B 2 312 ? 17.94278 -9.75070  20.10507  1.000 48.87380  ? 310 GLN A NE2 1 
ATOM   2469 N N   . TYR B 2 313 ? 18.88108 -10.54469 14.45883  1.000 17.86071  ? 311 TYR A N   1 
ATOM   2470 C CA  . TYR B 2 313 ? 20.08972 -10.01637 13.83697  1.000 16.76071  ? 311 TYR A CA  1 
ATOM   2471 C C   . TYR B 2 313 ? 20.34241 -10.53186 12.42965  1.000 17.03071  ? 311 TYR A C   1 
ATOM   2472 O O   . TYR B 2 313 ? 21.06050 -9.87638  11.66989  1.000 19.27071  ? 311 TYR A O   1 
ATOM   2473 C CB  . TYR B 2 313 ? 21.31361 -10.34995 14.69829  1.000 16.44071  ? 311 TYR A CB  1 
ATOM   2474 C CG  . TYR B 2 313 ? 21.32046 -9.59600  15.98531  1.000 19.65071  ? 311 TYR A CG  1 
ATOM   2475 C CD1 . TYR B 2 313 ? 21.46462 -8.21645  15.98428  1.000 23.98071  ? 311 TYR A CD1 1 
ATOM   2476 C CD2 . TYR B 2 313 ? 21.15020 -10.24279 17.19820  1.000 21.35071  ? 311 TYR A CD2 1 
ATOM   2477 C CE1 . TYR B 2 313 ? 21.46126 -7.50022  17.15433  1.000 27.75071  ? 311 TYR A CE1 1 
ATOM   2478 C CE2 . TYR B 2 313 ? 21.14521 -9.53142  18.38498  1.000 24.36071  ? 311 TYR A CE2 1 
ATOM   2479 C CZ  . TYR B 2 313 ? 21.30384 -8.15712  18.35138  1.000 25.91071  ? 311 TYR A CZ  1 
ATOM   2480 O OH  . TYR B 2 313 ? 21.30021 -7.41748  19.50941  1.000 30.78071  ? 311 TYR A OH  1 
ATOM   2481 N N   . HIS B 2 314 ? 19.79420 -11.68763 12.07848  1.000 17.26532  ? 312 HIS A N   1 
ATOM   2482 C CA  . HIS B 2 314 ? 20.13858 -12.36116 10.83178  1.000 16.47532  ? 312 HIS A CA  1 
ATOM   2483 C C   . HIS B 2 314 ? 19.64525 -11.56174 9.63321   1.000 21.73532  ? 312 HIS A C   1 
ATOM   2484 O O   . HIS B 2 314 ? 18.48680 -11.14123 9.58908   1.000 19.64532  ? 312 HIS A O   1 
ATOM   2485 C CB  . HIS B 2 314 ? 19.52800 -13.75537 10.84481  1.000 15.42532  ? 312 HIS A CB  1 
ATOM   2486 C CG  . HIS B 2 314 ? 19.65962 -14.51722 9.55939   1.000 14.30532  ? 312 HIS A CG  1 
ATOM   2487 N ND1 . HIS B 2 314 ? 20.84971 -14.63602 8.86725   1.000 13.34532  ? 312 HIS A ND1 1 
ATOM   2488 C CD2 . HIS B 2 314 ? 18.74742 -15.24289 8.86972   1.000 14.14532  ? 312 HIS A CD2 1 
ATOM   2489 C CE1 . HIS B 2 314 ? 20.65531 -15.39066 7.79879   1.000 14.91532  ? 312 HIS A CE1 1 
ATOM   2490 N NE2 . HIS B 2 314 ? 19.38881 -15.77089 7.77739   1.000 14.30532  ? 312 HIS A NE2 1 
ATOM   2491 N N   . ASP B 2 315 ? 20.54808 -11.32146 8.68380   1.000 18.54389  ? 313 ASP A N   1 
ATOM   2492 C CA  . ASP B 2 315 ? 20.23758 -10.61636 7.44078   1.000 22.29389  ? 313 ASP A CA  1 
ATOM   2493 C C   . ASP B 2 315 ? 21.05564 -11.29569 6.35588   1.000 19.36389  ? 313 ASP A C   1 
ATOM   2494 O O   . ASP B 2 315 ? 22.26564 -11.04598 6.23740   1.000 14.76389  ? 313 ASP A O   1 
ATOM   2495 C CB  . ASP B 2 315 ? 20.57575 -9.13086  7.53628   1.000 23.60389  ? 313 ASP A CB  1 
ATOM   2496 C CG  . ASP B 2 315 ? 20.21742 -8.34128  6.26117   1.000 25.34389  ? 313 ASP A CG  1 
ATOM   2497 O OD1 . ASP B 2 315 ? 19.76047 -8.91708  5.24189   1.000 25.28389  ? 313 ASP A OD1 1 
ATOM   2498 O OD2 . ASP B 2 315 ? 20.40535 -7.11061  6.29476   1.000 31.04389  ? 313 ASP A OD2 1 
ATOM   2499 N N   . PRO B 2 316 ? 20.43633 -12.14787 5.53698   1.000 21.85997  ? 314 PRO A N   1 
ATOM   2500 C CA  . PRO B 2 316 ? 21.22408 -12.91035 4.55624   1.000 22.67997  ? 314 PRO A CA  1 
ATOM   2501 C C   . PRO B 2 316 ? 21.82552 -12.04311 3.45657   1.000 25.08997  ? 314 PRO A C   1 
ATOM   2502 O O   . PRO B 2 316 ? 22.78865 -12.47291 2.80853   1.000 29.37997  ? 314 PRO A O   1 
ATOM   2503 C CB  . PRO B 2 316 ? 20.21398 -13.92499 4.00413   1.000 26.22997  ? 314 PRO A CB  1 
ATOM   2504 C CG  . PRO B 2 316 ? 18.86977 -13.30387 4.25339   1.000 26.08997  ? 314 PRO A CG  1 
ATOM   2505 C CD  . PRO B 2 316 ? 18.99448 -12.45231 5.47778   1.000 24.46997  ? 314 PRO A CD  1 
ATOM   2506 N N   . ASP B 2 317 ? 21.33343 -10.82221 3.26316   1.000 24.07043  ? 315 ASP A N   1 
ATOM   2507 C CA  . ASP B 2 317 ? 21.96877 -9.88958  2.33883   1.000 25.99043  ? 315 ASP A CA  1 
ATOM   2508 C C   . ASP B 2 317 ? 23.12649 -9.12241  2.96337   1.000 23.34043  ? 315 ASP A C   1 
ATOM   2509 O O   . ASP B 2 317 ? 23.78915 -8.34893  2.25976   1.000 21.58043  ? 315 ASP A O   1 
ATOM   2510 C CB  . ASP B 2 317 ? 20.93095 -8.90069  1.79896   1.000 28.23043  ? 315 ASP A CB  1 
ATOM   2511 C CG  . ASP B 2 317 ? 19.89272 -9.57552  0.93006   1.000 37.94043  ? 315 ASP A CG  1 
ATOM   2512 O OD1 . ASP B 2 317 ? 20.26515 -10.53270 0.21856   1.000 41.46043  ? 315 ASP A OD1 1 
ATOM   2513 O OD2 . ASP B 2 317 ? 18.70864 -9.16285  0.96193   1.000 48.60043  ? 315 ASP A OD2 1 
ATOM   2514 N N   . ASP B 2 318 ? 23.38933 -9.30582  4.25636   1.000 20.12501  ? 316 ASP A N   1 
ATOM   2515 C CA  . ASP B 2 318 ? 24.47467 -8.60432  4.93036   1.000 21.11501  ? 316 ASP A CA  1 
ATOM   2516 C C   . ASP B 2 318 ? 25.39683 -9.59579  5.64609   1.000 17.20501  ? 316 ASP A C   1 
ATOM   2517 O O   . ASP B 2 318 ? 25.95323 -9.29980  6.71189   1.000 16.67501  ? 316 ASP A O   1 
ATOM   2518 C CB  . ASP B 2 318 ? 23.91872 -7.56186  5.89876   1.000 24.96501  ? 316 ASP A CB  1 
ATOM   2519 C CG  . ASP B 2 318 ? 24.97357 -6.55621  6.35200   1.000 31.83501  ? 316 ASP A CG  1 
ATOM   2520 O OD1 . ASP B 2 318 ? 25.92942 -6.30662  5.58340   1.000 34.20501  ? 316 ASP A OD1 1 
ATOM   2521 O OD2 . ASP B 2 318 ? 24.86898 -6.06716  7.50064   1.000 37.23501  ? 316 ASP A OD2 1 
ATOM   2522 N N   . GLU B 2 319 ? 25.55796 -10.79322 5.08303   1.000 15.24854  ? 317 GLU A N   1 
ATOM   2523 C CA  . GLU B 2 319 ? 26.46699 -11.80700 5.61954   1.000 14.10854  ? 317 GLU A CA  1 
ATOM   2524 C C   . GLU B 2 319 ? 27.37711 -12.27512 4.48553   1.000 12.87854  ? 317 GLU A C   1 
ATOM   2525 O O   . GLU B 2 319 ? 27.23120 -13.38230 3.96117   1.000 14.69854  ? 317 GLU A O   1 
ATOM   2526 C CB  . GLU B 2 319 ? 25.67446 -12.94060 6.27933   1.000 13.58854  ? 317 GLU A CB  1 
ATOM   2527 C CG  . GLU B 2 319 ? 24.91534 -12.41092 7.54207   1.000 13.40854  ? 317 GLU A CG  1 
ATOM   2528 C CD  . GLU B 2 319 ? 23.74464 -13.27935 8.00096   1.000 14.81854  ? 317 GLU A CD  1 
ATOM   2529 O OE1 . GLU B 2 319 ? 23.47220 -14.31612 7.34968   1.000 17.58854  ? 317 GLU A OE1 1 
ATOM   2530 O OE2 . GLU B 2 319 ? 23.09778 -12.91241 9.02314   1.000 16.39854  ? 317 GLU A OE2 1 
ATOM   2531 N N   . PRO B 2 320 ? 28.34696 -11.44668 4.10168   1.000 13.93725  ? 318 PRO A N   1 
ATOM   2532 C CA  . PRO B 2 320 ? 29.11257 -11.69852 2.87595   1.000 16.33725  ? 318 PRO A CA  1 
ATOM   2533 C C   . PRO B 2 320 ? 30.13027 -12.82149 3.02319   1.000 16.91725  ? 318 PRO A C   1 
ATOM   2534 O O   . PRO B 2 320 ? 30.60121 -13.15658 4.11837   1.000 13.61725  ? 318 PRO A O   1 
ATOM   2535 C CB  . PRO B 2 320 ? 29.82198 -10.36340 2.62721   1.000 16.84725  ? 318 PRO A CB  1 
ATOM   2536 C CG  . PRO B 2 320 ? 29.98843 -9.77402  3.98814   1.000 17.17725  ? 318 PRO A CG  1 
ATOM   2537 C CD  . PRO B 2 320 ? 28.76456 -10.20170 4.77388   1.000 14.28725  ? 318 PRO A CD  1 
ATOM   2538 N N   . VAL B 2 321 ? 30.46293 -13.39773 1.87489   1.000 15.42734  ? 319 VAL A N   1 
ATOM   2539 C CA  . VAL B 2 321 ? 31.50153 -14.40069 1.76706   1.000 14.36734  ? 319 VAL A CA  1 
ATOM   2540 C C   . VAL B 2 321 ? 32.77178 -13.74686 1.23389   1.000 12.60734  ? 319 VAL A C   1 
ATOM   2541 O O   . VAL B 2 321 ? 32.77060 -12.60302 0.78147   1.000 14.07734  ? 319 VAL A O   1 
ATOM   2542 C CB  . VAL B 2 321 ? 31.06177 -15.57927 0.86736   1.000 17.79734  ? 319 VAL A CB  1 
ATOM   2543 C CG1 . VAL B 2 321 ? 29.85662 -16.27453 1.47539   1.000 19.29734  ? 319 VAL A CG1 1 
ATOM   2544 C CG2 . VAL B 2 321 ? 30.76596 -15.07537 -0.56238  1.000 17.72734  ? 319 VAL A CG2 1 
ATOM   2545 N N   . ALA B 2 322 ? 33.87664 -14.47380 1.31118   1.000 12.76951  ? 320 ALA A N   1 
ATOM   2546 C CA  . ALA B 2 322 ? 35.18101 -13.98318 0.91189   1.000 13.11951  ? 320 ALA A CA  1 
ATOM   2547 C C   . ALA B 2 322 ? 35.46683 -14.32803 -0.54095  1.000 14.69951  ? 320 ALA A C   1 
ATOM   2548 O O   . ALA B 2 322 ? 34.89453 -15.26460 -1.10605  1.000 14.68951  ? 320 ALA A O   1 
ATOM   2549 C CB  . ALA B 2 322 ? 36.28241 -14.58886 1.78606   1.000 13.14951  ? 320 ALA A CB  1 
ATOM   2550 N N   . ASP B 2 323 ? 36.39825 -13.57656 -1.12511  1.000 14.60092  ? 321 ASP A N   1 
ATOM   2551 C CA  . ASP B 2 323 ? 37.03303 -14.01511 -2.35796  1.000 18.48092  ? 321 ASP A CA  1 
ATOM   2552 C C   . ASP B 2 323 ? 37.77690 -15.32035 -2.10232  1.000 17.30092  ? 321 ASP A C   1 
ATOM   2553 O O   . ASP B 2 323 ? 38.19272 -15.58528 -0.97098  1.000 13.84092  ? 321 ASP A O   1 
ATOM   2554 C CB  . ASP B 2 323 ? 38.01052 -12.95788 -2.86936  1.000 24.13092  ? 321 ASP A CB  1 
ATOM   2555 C CG  . ASP B 2 323 ? 37.31565 -11.69804 -3.28826  1.000 29.96092  ? 321 ASP A CG  1 
ATOM   2556 O OD1 . ASP B 2 323 ? 36.10916 -11.78670 -3.61269  1.000 31.81092  ? 321 ASP A OD1 1 
ATOM   2557 O OD2 . ASP B 2 323 ? 37.96193 -10.62861 -3.28911  1.000 42.41092  ? 321 ASP A OD2 1 
ATOM   2558 N N   . PRO B 2 324 ? 37.93886 -16.16011 -3.12620  1.000 19.66089  ? 322 PRO A N   1 
ATOM   2559 C CA  . PRO B 2 324 ? 38.73166 -17.38419 -2.94875  1.000 20.54089  ? 322 PRO A CA  1 
ATOM   2560 C C   . PRO B 2 324 ? 40.16872 -17.03346 -2.60597  1.000 16.76089  ? 322 PRO A C   1 
ATOM   2561 O O   . PRO B 2 324 ? 40.69500 -16.01236 -3.04487  1.000 15.35089  ? 322 PRO A O   1 
ATOM   2562 C CB  . PRO B 2 324 ? 38.61776 -18.09099 -4.30526  1.000 23.22089  ? 322 PRO A CB  1 
ATOM   2563 C CG  . PRO B 2 324 ? 38.15307 -17.02951 -5.26470  1.000 23.38089  ? 322 PRO A CG  1 
ATOM   2564 C CD  . PRO B 2 324 ? 37.31347 -16.08657 -4.46208  1.000 21.58089  ? 322 PRO A CD  1 
ATOM   2565 N N   . TYR B 2 325 ? 40.76655 -17.84324 -1.74431  1.000 15.38758  ? 323 TYR A N   1 
ATOM   2566 C CA  . TYR B 2 325 ? 42.08509 -17.57240 -1.19058  1.000 16.95758  ? 323 TYR A CA  1 
ATOM   2567 C C   . TYR B 2 325 ? 43.02790 -18.65226 -1.69316  1.000 16.71758  ? 323 TYR A C   1 
ATOM   2568 O O   . TYR B 2 325 ? 42.82752 -19.83858 -1.40683  1.000 15.94758  ? 323 TYR A O   1 
ATOM   2569 C CB  . TYR B 2 325 ? 42.03328 -17.53110 0.34101   1.000 16.62758  ? 323 TYR A CB  1 
ATOM   2570 C CG  . TYR B 2 325 ? 43.36455 -17.35083 1.05182   1.000 15.04758  ? 323 TYR A CG  1 
ATOM   2571 C CD1 . TYR B 2 325 ? 44.24772 -16.33243 0.69685   1.000 16.10758  ? 323 TYR A CD1 1 
ATOM   2572 C CD2 . TYR B 2 325 ? 43.71766 -18.17536 2.10982   1.000 15.91758  ? 323 TYR A CD2 1 
ATOM   2573 C CE1 . TYR B 2 325 ? 45.46020 -16.15704 1.36838   1.000 14.06758  ? 323 TYR A CE1 1 
ATOM   2574 C CE2 . TYR B 2 325 ? 44.92860 -18.00367 2.77907   1.000 19.78758  ? 323 TYR A CE2 1 
ATOM   2575 C CZ  . TYR B 2 325 ? 45.78954 -16.99119 2.39800   1.000 16.62758  ? 323 TYR A CZ  1 
ATOM   2576 O OH  . TYR B 2 325 ? 46.98434 -16.84856 3.07197   1.000 18.68758  ? 323 TYR A OH  1 
ATOM   2577 N N   . ASP B 2 326 ? 44.04473 -18.23855 -2.44911  1.000 13.40964  ? 324 ASP A N   1 
ATOM   2578 C CA  . ASP B 2 326 ? 44.96917 -19.17010 -3.08384  1.000 13.75964  ? 324 ASP A CA  1 
ATOM   2579 C C   . ASP B 2 326 ? 45.98519 -19.61685 -2.05127  1.000 11.55964  ? 324 ASP A C   1 
ATOM   2580 O O   . ASP B 2 326 ? 46.89141 -18.85755 -1.69539  1.000 11.93964  ? 324 ASP A O   1 
ATOM   2581 C CB  . ASP B 2 326 ? 45.66237 -18.51118 -4.27655  1.000 18.35964  ? 324 ASP A CB  1 
ATOM   2582 C CG  . ASP B 2 326 ? 46.51318 -19.49958 -5.10596  1.000 24.44964  ? 324 ASP A CG  1 
ATOM   2583 O OD1 . ASP B 2 326 ? 47.12187 -20.44094 -4.55831  1.000 24.82964  ? 324 ASP A OD1 1 
ATOM   2584 O OD2 . ASP B 2 326 ? 46.56671 -19.34064 -6.33664  1.000 37.69964  ? 324 ASP A OD2 1 
ATOM   2585 N N   . GLN B 2 327 ? 45.90743 -20.87847 -1.64730  1.000 12.03727  ? 325 GLN A N   1 
ATOM   2586 C CA  . GLN B 2 327 ? 46.85450 -21.41530 -0.68287  1.000 13.52727  ? 325 GLN A CA  1 
ATOM   2587 C C   . GLN B 2 327 ? 47.85552 -22.36990 -1.30510  1.000 13.57727  ? 325 GLN A C   1 
ATOM   2588 O O   . GLN B 2 327 ? 48.53610 -23.10331 -0.57722  1.000 13.00727  ? 325 GLN A O   1 
ATOM   2589 C CB  . GLN B 2 327 ? 46.10997 -22.09963 0.45480   1.000 17.41727  ? 325 GLN A CB  1 
ATOM   2590 C CG  . GLN B 2 327 ? 45.38009 -21.10075 1.27723   1.000 18.45727  ? 325 GLN A CG  1 
ATOM   2591 C CD  . GLN B 2 327 ? 44.79906 -21.68663 2.53183   1.000 22.38727  ? 325 GLN A CD  1 
ATOM   2592 O OE1 . GLN B 2 327 ? 45.52116 -21.96564 3.49254   1.000 25.15727  ? 325 GLN A OE1 1 
ATOM   2593 N NE2 . GLN B 2 327 ? 43.49073 -21.88590 2.53498   1.000 24.51727  ? 325 GLN A NE2 1 
ATOM   2594 N N   . SER B 2 328 ? 47.99392 -22.33925 -2.63203  1.000 16.18326  ? 326 SER A N   1 
ATOM   2595 C CA  . SER B 2 328 ? 48.93226 -23.22827 -3.30497  1.000 17.80326  ? 326 SER A CA  1 
ATOM   2596 C C   . SER B 2 328 ? 50.38015 -22.97929 -2.89821  1.000 15.51326  ? 326 SER A C   1 
ATOM   2597 O O   . SER B 2 328 ? 51.19587 -23.89581 -3.03835  1.000 16.26326  ? 326 SER A O   1 
ATOM   2598 C CB  . SER B 2 328 ? 48.80966 -23.08879 -4.81538  1.000 17.44326  ? 326 SER A CB  1 
ATOM   2599 O OG  . SER B 2 328 ? 49.24955 -21.79798 -5.19190  1.000 18.57326  ? 326 SER A OG  1 
ATOM   2600 N N   . PHE B 2 329 ? 50.71379 -21.78728 -2.37489  1.000 13.41696  ? 327 PHE A N   1 
ATOM   2601 C CA  . PHE B 2 329 ? 52.06983 -21.55405 -1.86986  1.000 12.95696  ? 327 PHE A CA  1 
ATOM   2602 C C   . PHE B 2 329 ? 52.46268 -22.54012 -0.77539  1.000 13.17696  ? 327 PHE A C   1 
ATOM   2603 O O   . PHE B 2 329 ? 53.65601 -22.77746 -0.57807  1.000 12.21696  ? 327 PHE A O   1 
ATOM   2604 C CB  . PHE B 2 329 ? 52.23623 -20.11824 -1.34560  1.000 13.28696  ? 327 PHE A CB  1 
ATOM   2605 C CG  . PHE B 2 329 ? 51.50636 -19.83144 -0.04659  1.000 13.23696  ? 327 PHE A CG  1 
ATOM   2606 C CD1 . PHE B 2 329 ? 52.13615 -20.01394 1.19263   1.000 14.64696  ? 327 PHE A CD1 1 
ATOM   2607 C CD2 . PHE B 2 329 ? 50.21212 -19.33126 -0.07165  1.000 13.24696  ? 327 PHE A CD2 1 
ATOM   2608 C CE1 . PHE B 2 329 ? 51.47318 -19.74677 2.37778   1.000 15.34696  ? 327 PHE A CE1 1 
ATOM   2609 C CE2 . PHE B 2 329 ? 49.54361 -19.03317 1.11414   1.000 14.86696  ? 327 PHE A CE2 1 
ATOM   2610 C CZ  . PHE B 2 329 ? 50.17620 -19.24367 2.33842   1.000 14.64696  ? 327 PHE A CZ  1 
ATOM   2611 N N   . GLU B 2 330 ? 51.48303 -23.10257 -0.04952  1.000 13.69515  ? 328 GLU A N   1 
ATOM   2612 C CA  . GLU B 2 330 ? 51.78478 -23.97795 1.08144   1.000 18.42515  ? 328 GLU A CA  1 
ATOM   2613 C C   . GLU B 2 330 ? 52.55494 -25.22759 0.66479   1.000 20.58515  ? 328 GLU A C   1 
ATOM   2614 O O   . GLU B 2 330 ? 53.32583 -25.77317 1.46809   1.000 21.87515  ? 328 GLU A O   1 
ATOM   2615 C CB  . GLU B 2 330 ? 50.49696 -24.38463 1.81141   1.000 21.23515  ? 328 GLU A CB  1 
ATOM   2616 C CG  . GLU B 2 330 ? 49.81254 -23.27263 2.62568   1.000 21.33515  ? 328 GLU A CG  1 
ATOM   2617 C CD  . GLU B 2 330 ? 50.57355 -22.87803 3.89946   1.000 24.11515  ? 328 GLU A CD  1 
ATOM   2618 O OE1 . GLU B 2 330 ? 51.67772 -23.40775 4.17176   1.000 19.53515  ? 328 GLU A OE1 1 
ATOM   2619 O OE2 . GLU B 2 330 ? 50.05216 -22.01763 4.64555   1.000 24.51515  ? 328 GLU A OE2 1 
ATOM   2620 N N   . SER B 2 331 ? 52.39556 -25.67085 -0.58355  1.000 18.14004  ? 329 SER A N   1 
ATOM   2621 C CA  . SER B 2 331 ? 53.11922 -26.83028 -1.08298  1.000 22.76004  ? 329 SER A CA  1 
ATOM   2622 C C   . SER B 2 331 ? 54.40068 -26.45563 -1.81884  1.000 21.58004  ? 329 SER A C   1 
ATOM   2623 O O   . SER B 2 331 ? 54.99866 -27.31703 -2.47253  1.000 22.65004  ? 329 SER A O   1 
ATOM   2624 C CB  . SER B 2 331 ? 52.21884 -27.66829 -1.99424  1.000 21.91004  ? 329 SER A CB  1 
ATOM   2625 O OG  . SER B 2 331 ? 51.97299 -26.98091 -3.19838  1.000 30.38004  ? 329 SER A OG  1 
ATOM   2626 N N   . ARG B 2 332 ? 54.85175 -25.20962 -1.72132  1.000 16.65545  ? 330 ARG A N   1 
ATOM   2627 C CA  . ARG B 2 332 ? 56.09211 -24.83099 -2.37138  1.000 15.76545  ? 330 ARG A CA  1 
ATOM   2628 C C   . ARG B 2 332 ? 57.25679 -25.05195 -1.42343  1.000 16.68545  ? 330 ARG A C   1 
ATOM   2629 O O   . ARG B 2 332 ? 57.13220 -24.87039 -0.21165  1.000 18.45545  ? 330 ARG A O   1 
ATOM   2630 C CB  . ARG B 2 332 ? 56.04561 -23.37426 -2.84453  1.000 15.55545  ? 330 ARG A CB  1 
ATOM   2631 C CG  . ARG B 2 332 ? 54.99374 -23.12988 -3.93643  1.000 14.88545  ? 330 ARG A CG  1 
ATOM   2632 C CD  . ARG B 2 332 ? 54.93956 -21.66526 -4.35807  1.000 13.72545  ? 330 ARG A CD  1 
ATOM   2633 N NE  . ARG B 2 332 ? 56.06539 -21.30913 -5.21590  1.000 12.01545  ? 330 ARG A NE  1 
ATOM   2634 C CZ  . ARG B 2 332 ? 56.25932 -20.10017 -5.72618  1.000 12.32545  ? 330 ARG A CZ  1 
ATOM   2635 N NH1 . ARG B 2 332 ? 55.45706 -19.08242 -5.42210  1.000 11.40545  ? 330 ARG A NH1 1 
ATOM   2636 N NH2 . ARG B 2 332 ? 57.26334 -19.91099 -6.58131  1.000 11.58545  ? 330 ARG A NH2 1 
ATOM   2637 N N   . ASP B 2 333 ? 58.39000 -25.45910 -1.97324  1.000 16.96260  ? 331 ASP A N   1 
ATOM   2638 C CA  . ASP B 2 333 ? 59.60006 -25.62488 -1.17497  1.000 21.92260  ? 331 ASP A CA  1 
ATOM   2639 C C   . ASP B 2 333 ? 60.65847 -24.69710 -1.74716  1.000 16.43260  ? 331 ASP A C   1 
ATOM   2640 O O   . ASP B 2 333 ? 61.20987 -24.96846 -2.81977  1.000 17.82260  ? 331 ASP A O   1 
ATOM   2641 C CB  . ASP B 2 333 ? 60.05789 -27.08526 -1.15890  1.000 30.55260  ? 331 ASP A CB  1 
ATOM   2642 C CG  . ASP B 2 333 ? 59.12929 -27.97591 -0.32992  1.000 43.65260  ? 331 ASP A CG  1 
ATOM   2643 O OD1 . ASP B 2 333 ? 58.89055 -27.64936 0.85892   1.000 53.71260  ? 331 ASP A OD1 1 
ATOM   2644 O OD2 . ASP B 2 333 ? 58.62274 -28.99304 -0.86102  1.000 53.85260  ? 331 ASP A OD2 1 
ATOM   2645 N N   . LEU B 2 334 ? 60.93371 -23.59637 -1.04442  1.000 15.16348  ? 332 LEU A N   1 
ATOM   2646 C CA  . LEU B 2 334 ? 61.74573 -22.51237 -1.58429  1.000 14.19348  ? 332 LEU A CA  1 
ATOM   2647 C C   . LEU B 2 334 ? 62.87655 -22.15382 -0.63161  1.000 14.39348  ? 332 LEU A C   1 
ATOM   2648 O O   . LEU B 2 334 ? 62.83380 -22.46023 0.56276   1.000 15.48348  ? 332 LEU A O   1 
ATOM   2649 C CB  . LEU B 2 334 ? 60.89088 -21.25539 -1.84222  1.000 14.08348  ? 332 LEU A CB  1 
ATOM   2650 C CG  . LEU B 2 334 ? 59.56790 -21.47690 -2.58072  1.000 13.96348  ? 332 LEU A CG  1 
ATOM   2651 C CD1 . LEU B 2 334 ? 58.77344 -20.18200 -2.63038  1.000 13.36348  ? 332 LEU A CD1 1 
ATOM   2652 C CD2 . LEU B 2 334 ? 59.83904 -21.99992 -3.99501  1.000 14.69348  ? 332 LEU A CD2 1 
ATOM   2653 N N   . LEU B 2 335 ? 63.87459 -21.46375 -1.17445  1.000 14.40567  ? 333 LEU A N   1 
ATOM   2654 C CA  . LEU B 2 335 ? 64.96507 -20.91727 -0.37860  1.000 15.93567  ? 333 LEU A CA  1 
ATOM   2655 C C   . LEU B 2 335 ? 64.45864 -19.80830 0.54763   1.000 18.21567  ? 333 LEU A C   1 
ATOM   2656 O O   . LEU B 2 335 ? 63.40579 -19.20365 0.30644   1.000 13.75567  ? 333 LEU A O   1 
ATOM   2657 C CB  . LEU B 2 335 ? 66.05045 -20.34778 -1.29251  1.000 15.91567  ? 333 LEU A CB  1 
ATOM   2658 C CG  . LEU B 2 335 ? 66.59035 -21.29545 -2.36612  1.000 18.55567  ? 333 LEU A CG  1 
ATOM   2659 C CD1 . LEU B 2 335 ? 67.60599 -20.56009 -3.25618  1.000 21.07567  ? 333 LEU A CD1 1 
ATOM   2660 C CD2 . LEU B 2 335 ? 67.20709 -22.51735 -1.70260  1.000 17.38567  ? 333 LEU A CD2 1 
ATOM   2661 N N   . ILE B 2 336 ? 65.23453 -19.53832 1.61335   1.000 15.64751  ? 334 ILE A N   1 
ATOM   2662 C CA  . ILE B 2 336 ? 64.93028 -18.42707 2.52994   1.000 18.45751  ? 334 ILE A CA  1 
ATOM   2663 C C   . ILE B 2 336 ? 64.74247 -17.12677 1.76216   1.000 16.79751  ? 334 ILE A C   1 
ATOM   2664 O O   . ILE B 2 336 ? 63.75661 -16.40595 1.95778   1.000 14.97751  ? 334 ILE A O   1 
ATOM   2665 C CB  . ILE B 2 336 ? 66.03958 -18.25512 3.58618   1.000 22.32751  ? 334 ILE A CB  1 
ATOM   2666 C CG1 . ILE B 2 336 ? 66.08172 -19.40816 4.57085   1.000 28.13751  ? 334 ILE A CG1 1 
ATOM   2667 C CG2 . ILE B 2 336 ? 65.83000 -16.95800 4.38632   1.000 21.40751  ? 334 ILE A CG2 1 
ATOM   2668 C CD1 . ILE B 2 336 ? 67.18499 -19.23480 5.62161   1.000 32.12751  ? 334 ILE A CD1 1 
ATOM   2669 N N   . ASP B 2 337 ? 65.69036 -16.80842 0.87158   1.000 17.55546  ? 335 ASP A N   1 
ATOM   2670 C CA  . ASP B 2 337 ? 65.62094 -15.54358 0.15037   1.000 19.49546  ? 335 ASP A CA  1 
ATOM   2671 C C   . ASP B 2 337 ? 64.46597 -15.50319 -0.84077  1.000 16.12546  ? 335 ASP A C   1 
ATOM   2672 O O   . ASP B 2 337 ? 64.01341 -14.40746 -1.19224  1.000 17.08546  ? 335 ASP A O   1 
ATOM   2673 C CB  . ASP B 2 337 ? 66.93493 -15.26324 -0.57465  1.000 25.60546  ? 335 ASP A CB  1 
ATOM   2674 C CG  . ASP B 2 337 ? 67.97038 -14.58862 0.32233   1.000 40.39546  ? 335 ASP A CG  1 
ATOM   2675 O OD1 . ASP B 2 337 ? 67.70302 -14.39095 1.53432   1.000 41.77546  ? 335 ASP A OD1 1 
ATOM   2676 O OD2 . ASP B 2 337 ? 69.05818 -14.24412 -0.19240  1.000 60.87546  ? 335 ASP A OD2 1 
ATOM   2677 N N   . GLU B 2 338 ? 63.98004 -16.66415 -1.28262  1.000 13.76670  ? 336 GLU A N   1 
ATOM   2678 C CA  . GLU B 2 338 ? 62.80559 -16.70398 -2.14648  1.000 13.25670  ? 336 GLU A CA  1 
ATOM   2679 C C   . GLU B 2 338 ? 61.53327 -16.37797 -1.36691  1.000 11.69670  ? 336 GLU A C   1 
ATOM   2680 O O   . GLU B 2 338 ? 60.71221 -15.58741 -1.83082  1.000 10.86670  ? 336 GLU A O   1 
ATOM   2681 C CB  . GLU B 2 338 ? 62.70722 -18.07122 -2.82968  1.000 13.91670  ? 336 GLU A CB  1 
ATOM   2682 C CG  . GLU B 2 338 ? 63.76384 -18.24485 -3.93669  1.000 15.18670  ? 336 GLU A CG  1 
ATOM   2683 C CD  . GLU B 2 338 ? 63.69960 -19.60773 -4.60960  1.000 14.37670  ? 336 GLU A CD  1 
ATOM   2684 O OE1 . GLU B 2 338 ? 63.45411 -20.60972 -3.90539  1.000 13.57670  ? 336 GLU A OE1 1 
ATOM   2685 O OE2 . GLU B 2 338 ? 63.88853 -19.67290 -5.85322  1.000 15.88670  ? 336 GLU A OE2 1 
ATOM   2686 N N   . TRP B 2 339 ? 61.35892 -16.96356 -0.17328  1.000 11.07997  ? 337 TRP A N   1 
ATOM   2687 C CA  . TRP B 2 339 ? 60.23857 -16.56768 0.68876   1.000 11.49997  ? 337 TRP A CA  1 
ATOM   2688 C C   . TRP B 2 339 ? 60.34233 -15.09793 1.07752   1.000 12.23997  ? 337 TRP A C   1 
ATOM   2689 O O   . TRP B 2 339 ? 59.33363 -14.38468 1.13049   1.000 12.04997  ? 337 TRP A O   1 
ATOM   2690 C CB  . TRP B 2 339 ? 60.19675 -17.43677 1.94774   1.000 10.94997  ? 337 TRP A CB  1 
ATOM   2691 C CG  . TRP B 2 339 ? 59.75946 -18.83289 1.72097   1.000 10.07997  ? 337 TRP A CG  1 
ATOM   2692 C CD1 . TRP B 2 339 ? 60.48740 -19.96244 1.94173   1.000 10.10997  ? 337 TRP A CD1 1 
ATOM   2693 C CD2 . TRP B 2 339 ? 58.48416 -19.26133 1.22596   1.000 9.76997   ? 337 TRP A CD2 1 
ATOM   2694 N NE1 . TRP B 2 339 ? 59.74223 -21.07290 1.63137   1.000 10.17997  ? 337 TRP A NE1 1 
ATOM   2695 C CE2 . TRP B 2 339 ? 58.50560 -20.67019 1.19201   1.000 9.79997   ? 337 TRP A CE2 1 
ATOM   2696 C CE3 . TRP B 2 339 ? 57.31987 -18.58868 0.81990   1.000 10.32997  ? 337 TRP A CE3 1 
ATOM   2697 C CZ2 . TRP B 2 339 ? 57.42492 -21.42290 0.75034   1.000 9.71997   ? 337 TRP A CZ2 1 
ATOM   2698 C CZ3 . TRP B 2 339 ? 56.23342 -19.34383 0.38742   1.000 9.63997   ? 337 TRP A CZ3 1 
ATOM   2699 C CH2 . TRP B 2 339 ? 56.30002 -20.74223 0.34152   1.000 10.16997  ? 337 TRP A CH2 1 
ATOM   2700 N N   . LYS B 2 340 ? 61.56736 -14.63356 1.33112   1.000 12.36002  ? 338 LYS A N   1 
ATOM   2701 C CA  . LYS B 2 340 ? 61.81151 -13.23461 1.65448   1.000 15.08002  ? 338 LYS A CA  1 
ATOM   2702 C C   . LYS B 2 340 ? 61.42039 -12.33279 0.49272   1.000 13.50002  ? 338 LYS A C   1 
ATOM   2703 O O   . LYS B 2 340 ? 60.74827 -11.31456 0.67785   1.000 11.40002  ? 338 LYS A O   1 
ATOM   2704 C CB  . LYS B 2 340 ? 63.28846 -13.06687 2.01934   1.000 18.24002  ? 338 LYS A CB  1 
ATOM   2705 C CG  . LYS B 2 340 ? 63.73012 -11.68197 2.45052   1.000 21.32002  ? 338 LYS A CG  1 
ATOM   2706 C CD  . LYS B 2 340 ? 64.98300 -11.85367 3.30161   1.000 26.63002  ? 338 LYS A CD  1 
ATOM   2707 C CE  . LYS B 2 340 ? 65.98017 -10.73895 3.10435   1.000 36.59002  ? 338 LYS A CE  1 
ATOM   2708 N NZ  . LYS B 2 340 ? 67.08109 -10.83385 4.12236   1.000 40.89002  ? 338 LYS A NZ  1 
ATOM   2709 N N   . SER B 2 341 ? 61.81398 -12.71099 -0.72389  1.000 14.34053  ? 339 SER A N   1 
ATOM   2710 C CA  . SER B 2 341 ? 61.45960 -11.92663 -1.90085  1.000 13.90053  ? 339 SER A CA  1 
ATOM   2711 C C   . SER B 2 341 ? 59.94847 -11.93010 -2.15001  1.000 11.71053  ? 339 SER A C   1 
ATOM   2712 O O   . SER B 2 341 ? 59.37499 -10.90382 -2.52803  1.000 12.79053  ? 339 SER A O   1 
ATOM   2713 C CB  . SER B 2 341 ? 62.22378 -12.46635 -3.11478  1.000 16.04053  ? 339 SER A CB  1 
ATOM   2714 O OG  . SER B 2 341 ? 61.85792 -11.77166 -4.28047  1.000 18.12053  ? 339 SER A OG  1 
ATOM   2715 N N   . LEU B 2 342 ? 59.29418 -13.07411 -1.95331  1.000 10.78378  ? 340 LEU A N   1 
ATOM   2716 C CA  . LEU B 2 342 ? 57.83900 -13.13831 -2.04930  1.000 12.29378  ? 340 LEU A CA  1 
ATOM   2717 C C   . LEU B 2 342 ? 57.16696 -12.24134 -1.01591  1.000 12.38378  ? 340 LEU A C   1 
ATOM   2718 O O   . LEU B 2 342 ? 56.18889 -11.55226 -1.32770  1.000 10.09378  ? 340 LEU A O   1 
ATOM   2719 C CB  . LEU B 2 342 ? 57.37226 -14.57623 -1.86454  1.000 12.49378  ? 340 LEU A CB  1 
ATOM   2720 C CG  . LEU B 2 342 ? 57.61085 -15.48648 -3.05974  1.000 14.06378  ? 340 LEU A CG  1 
ATOM   2721 C CD1 . LEU B 2 342 ? 57.28980 -16.87814 -2.61079  1.000 13.51378  ? 340 LEU A CD1 1 
ATOM   2722 C CD2 . LEU B 2 342 ? 56.69863 -15.06528 -4.21826  1.000 16.03378  ? 340 LEU A CD2 1 
ATOM   2723 N N   . THR B 2 343 ? 57.69655 -12.21785 0.21342   1.000 10.63887  ? 341 THR A N   1 
ATOM   2724 C CA  . THR B 2 343 ? 57.14117 -11.35304 1.24901   1.000 10.74887  ? 341 THR A CA  1 
ATOM   2725 C C   . THR B 2 343 ? 57.29978 -9.88073  0.87789   1.000 10.62887  ? 341 THR A C   1 
ATOM   2726 O O   . THR B 2 343 ? 56.34336 -9.09797  0.97581   1.000 7.69887   ? 341 THR A O   1 
ATOM   2727 C CB  . THR B 2 343 ? 57.82363 -11.64693 2.58422   1.000 11.42887  ? 341 THR A CB  1 
ATOM   2728 O OG1 . THR B 2 343 ? 57.59981 -13.02127 2.92396   1.000 9.91887   ? 341 THR A OG1 1 
ATOM   2729 C CG2 . THR B 2 343 ? 57.25824 -10.73857 3.68799   1.000 12.27887  ? 341 THR A CG2 1 
ATOM   2730 N N   . TYR B 2 344 ? 58.50663 -9.49825  0.43141   1.000 11.33847  ? 342 TYR A N   1 
ATOM   2731 C CA  . TYR B 2 344 ? 58.75902 -8.12472  -0.00301  1.000 11.88847  ? 342 TYR A CA  1 
ATOM   2732 C C   . TYR B 2 344 ? 57.79506 -7.70240  -1.10910  1.000 11.53847  ? 342 TYR A C   1 
ATOM   2733 O O   . TYR B 2 344 ? 57.25885 -6.59098  -1.07013  1.000 11.81847  ? 342 TYR A O   1 
ATOM   2734 C CB  . TYR B 2 344 ? 60.21592 -7.98509  -0.46305  1.000 12.79847  ? 342 TYR A CB  1 
ATOM   2735 C CG  . TYR B 2 344 ? 60.62670 -6.58108  -0.79459  1.000 14.79847  ? 342 TYR A CG  1 
ATOM   2736 C CD1 . TYR B 2 344 ? 60.92160 -5.66701  0.21146   1.000 17.88847  ? 342 TYR A CD1 1 
ATOM   2737 C CD2 . TYR B 2 344 ? 60.73549 -6.16449  -2.11358  1.000 18.55847  ? 342 TYR A CD2 1 
ATOM   2738 C CE1 . TYR B 2 344 ? 61.30171 -4.36158  -0.09635  1.000 19.05847  ? 342 TYR A CE1 1 
ATOM   2739 C CE2 . TYR B 2 344 ? 61.11160 -4.86920  -2.43372  1.000 18.77847  ? 342 TYR A CE2 1 
ATOM   2740 C CZ  . TYR B 2 344 ? 61.39214 -3.97207  -1.42223  1.000 20.50847  ? 342 TYR A CZ  1 
ATOM   2741 O OH  . TYR B 2 344 ? 61.75767 -2.68292  -1.74784  1.000 22.27847  ? 342 TYR A OH  1 
ATOM   2742 N N   . ASP B 2 345 ? 57.53272 -8.59659  -2.07416  1.000 11.50213  ? 343 ASP A N   1 
ATOM   2743 C CA  . ASP B 2 345 ? 56.55356 -8.33260  -3.13467  1.000 13.21213  ? 343 ASP A CA  1 
ATOM   2744 C C   . ASP B 2 345 ? 55.17548 -8.03212  -2.56076  1.000 14.28213  ? 343 ASP A C   1 
ATOM   2745 O O   . ASP B 2 345 ? 54.44303 -7.17573  -3.08116  1.000 11.41213  ? 343 ASP A O   1 
ATOM   2746 C CB  . ASP B 2 345 ? 56.44200 -9.53257  -4.07810  1.000 15.99213  ? 343 ASP A CB  1 
ATOM   2747 C CG  . ASP B 2 345 ? 57.65448 -9.69942  -4.99204  1.000 21.26213  ? 343 ASP A CG  1 
ATOM   2748 O OD1 . ASP B 2 345 ? 58.54309 -8.81329  -4.98340  1.000 20.33213  ? 343 ASP A OD1 1 
ATOM   2749 O OD2 . ASP B 2 345 ? 57.72179 -10.73744 -5.70353  1.000 25.49213  ? 343 ASP A OD2 1 
ATOM   2750 N N   . GLU B 2 346 ? 54.80478 -8.73755  -1.49419  1.000 12.04742  ? 344 GLU A N   1 
ATOM   2751 C CA  . GLU B 2 346 ? 53.50372 -8.53550  -0.88799  1.000 12.82742  ? 344 GLU A CA  1 
ATOM   2752 C C   . GLU B 2 346 ? 53.45757 -7.25333  -0.08183  1.000 13.68742  ? 344 GLU A C   1 
ATOM   2753 O O   . GLU B 2 346 ? 52.40371 -6.60984  -0.03412  1.000 14.98742  ? 344 GLU A O   1 
ATOM   2754 C CB  . GLU B 2 346 ? 53.13962 -9.75246  -0.03122  1.000 13.91742  ? 344 GLU A CB  1 
ATOM   2755 C CG  . GLU B 2 346 ? 52.91739 -11.00896 -0.87914  1.000 14.93742  ? 344 GLU A CG  1 
ATOM   2756 C CD  . GLU B 2 346 ? 51.60528 -11.01016 -1.66779  1.000 15.74742  ? 344 GLU A CD  1 
ATOM   2757 O OE1 . GLU B 2 346 ? 50.69613 -10.22672 -1.33968  1.000 16.79742  ? 344 GLU A OE1 1 
ATOM   2758 O OE2 . GLU B 2 346 ? 51.46954 -11.81912 -2.61267  1.000 22.67742  ? 344 GLU A OE2 1 
ATOM   2759 N N   . VAL B 2 347 ? 54.57985 -6.85477  0.53187   1.000 12.20333  ? 345 VAL A N   1 
ATOM   2760 C CA  . VAL B 2 347 ? 54.64125 -5.54719  1.17248   1.000 12.10333  ? 345 VAL A CA  1 
ATOM   2761 C C   . VAL B 2 347 ? 54.45464 -4.44969  0.12895   1.000 16.45333  ? 345 VAL A C   1 
ATOM   2762 O O   . VAL B 2 347 ? 53.64824 -3.53001  0.30650   1.000 14.56333  ? 345 VAL A O   1 
ATOM   2763 C CB  . VAL B 2 347 ? 55.96116 -5.38135  1.94436   1.000 12.87333  ? 345 VAL A CB  1 
ATOM   2764 C CG1 . VAL B 2 347 ? 56.11052 -3.93813  2.44523   1.000 15.41333  ? 345 VAL A CG1 1 
ATOM   2765 C CG2 . VAL B 2 347 ? 56.04636 -6.35574  3.09830   1.000 13.08333  ? 345 VAL A CG2 1 
ATOM   2766 N N   . ILE B 2 348 ? 55.14834 -4.57945  -1.00656  1.000 16.88552  ? 346 ILE A N   1 
ATOM   2767 C CA  . ILE B 2 348 ? 55.10184 -3.58037  -2.07578  1.000 17.91552  ? 346 ILE A CA  1 
ATOM   2768 C C   . ILE B 2 348 ? 53.71189 -3.49614  -2.69934  1.000 14.89552  ? 346 ILE A C   1 
ATOM   2769 O O   . ILE B 2 348 ? 53.24605 -2.40819  -3.06342  1.000 16.76552  ? 346 ILE A O   1 
ATOM   2770 C CB  . ILE B 2 348 ? 56.18494 -3.90338  -3.13363  1.000 18.79552  ? 346 ILE A CB  1 
ATOM   2771 C CG1 . ILE B 2 348 ? 57.57619 -3.71656  -2.53405  1.000 22.39552  ? 346 ILE A CG1 1 
ATOM   2772 C CG2 . ILE B 2 348 ? 56.03725 -3.05179  -4.41500  1.000 22.31552  ? 346 ILE A CG2 1 
ATOM   2773 C CD1 . ILE B 2 348 ? 57.77891 -2.34987  -1.95521  1.000 24.24552  ? 346 ILE A CD1 1 
ATOM   2774 N N   . SER B 2 349 ? 53.03711 -4.63135  -2.86714  1.000 16.12789  ? 347 SER A N   1 
ATOM   2775 C CA  . SER B 2 349 ? 51.77280 -4.60772  -3.58377  1.000 16.86789  ? 347 SER A CA  1 
ATOM   2776 C C   . SER B 2 349 ? 50.59735 -4.20813  -2.70213  1.000 21.93789  ? 347 SER A C   1 
ATOM   2777 O O   . SER B 2 349 ? 49.46710 -4.18230  -3.20180  1.000 20.61789  ? 347 SER A O   1 
ATOM   2778 C CB  . SER B 2 349 ? 51.49872 -5.96706  -4.24668  1.000 18.43789  ? 347 SER A CB  1 
ATOM   2779 O OG  . SER B 2 349 ? 51.26937 -7.00392  -3.30759  1.000 16.78789  ? 347 SER A OG  1 
ATOM   2780 N N   . PHE B 2 350 ? 50.84232 -3.87087  -1.43269  1.000 20.54079  ? 348 PHE A N   1 
ATOM   2781 C CA  . PHE B 2 350 ? 49.76531 -3.67875  -0.46784  1.000 21.84079  ? 348 PHE A CA  1 
ATOM   2782 C C   . PHE B 2 350 ? 49.00449 -2.39056  -0.75830  1.000 24.50079  ? 348 PHE A C   1 
ATOM   2783 O O   . PHE B 2 350 ? 49.60224 -1.32068  -0.88180  1.000 20.59079  ? 348 PHE A O   1 
ATOM   2784 C CB  . PHE B 2 350 ? 50.32592 -3.63887  0.95398   1.000 17.40079  ? 348 PHE A CB  1 
ATOM   2785 C CG  . PHE B 2 350 ? 49.31624 -3.20388  2.00058   1.000 16.54079  ? 348 PHE A CG  1 
ATOM   2786 C CD1 . PHE B 2 350 ? 48.29236 -4.06021  2.39740   1.000 17.17079  ? 348 PHE A CD1 1 
ATOM   2787 C CD2 . PHE B 2 350 ? 49.40497 -1.95327  2.59162   1.000 16.52079  ? 348 PHE A CD2 1 
ATOM   2788 C CE1 . PHE B 2 350 ? 47.35644 -3.66036  3.35173   1.000 16.48079  ? 348 PHE A CE1 1 
ATOM   2789 C CE2 . PHE B 2 350 ? 48.47524 -1.53961  3.53742   1.000 16.38079  ? 348 PHE A CE2 1 
ATOM   2790 C CZ  . PHE B 2 350 ? 47.45184 -2.39949  3.91904   1.000 17.10079  ? 348 PHE A CZ  1 
ATOM   2791 N N   . VAL B 2 351 ? 47.68491 -2.49165  -0.80825  1.000 24.25835  ? 349 VAL A N   1 
ATOM   2792 C CA  . VAL B 2 351 ? 46.79972 -1.35267  -1.02416  1.000 28.25835  ? 349 VAL A CA  1 
ATOM   2793 C C   . VAL B 2 351 ? 46.06753 -1.08090  0.28340   1.000 24.44835  ? 349 VAL A C   1 
ATOM   2794 O O   . VAL B 2 351 ? 45.35264 -1.96317  0.77428   1.000 23.94835  ? 349 VAL A O   1 
ATOM   2795 C CB  . VAL B 2 351 ? 45.80367 -1.62581  -2.15737  1.000 29.20835  ? 349 VAL A CB  1 
ATOM   2796 C CG1 . VAL B 2 351 ? 44.96892 -0.38987  -2.43416  1.000 33.99835  ? 349 VAL A CG1 1 
ATOM   2797 C CG2 . VAL B 2 351 ? 46.54243 -2.11020  -3.40461  1.000 29.88835  ? 349 VAL A CG2 1 
ATOM   2798 N N   . PRO B 2 352 ? 46.20035 0.10755   0.86825   1.000 25.71440  ? 350 PRO A N   1 
ATOM   2799 C CA  . PRO B 2 352 ? 45.53920 0.37675   2.14428   1.000 31.48440  ? 350 PRO A CA  1 
ATOM   2800 C C   . PRO B 2 352 ? 44.02925 0.37180   1.99004   1.000 33.09440  ? 350 PRO A C   1 
ATOM   2801 O O   . PRO B 2 352 ? 43.50164 0.57198   0.88178   1.000 28.28440  ? 350 PRO A O   1 
ATOM   2802 C CB  . PRO B 2 352 ? 46.05364 1.77358   2.51990   1.000 34.13440  ? 350 PRO A CB  1 
ATOM   2803 C CG  . PRO B 2 352 ? 47.24001 2.01118   1.66011   1.000 33.64440  ? 350 PRO A CG  1 
ATOM   2804 C CD  . PRO B 2 352 ? 47.03675 1.23356   0.41948   1.000 30.27440  ? 350 PRO A CD  1 
ATOM   2805 N N   . PRO B 2 353 ? 43.29779 0.12837   3.07215   1.000 37.45214  ? 351 PRO A N   1 
ATOM   2806 C CA  . PRO B 2 353 ? 41.83771 0.24653   3.02522   1.000 41.57214  ? 351 PRO A CA  1 
ATOM   2807 C C   . PRO B 2 353 ? 41.42975 1.70293   2.90436   1.000 41.54214  ? 351 PRO A C   1 
ATOM   2808 O O   . PRO B 2 353 ? 42.21849 2.59762   3.24184   1.000 35.30214  ? 351 PRO A O   1 
ATOM   2809 C CB  . PRO B 2 353 ? 41.39340 -0.34691  4.37433   1.000 40.85214  ? 351 PRO A CB  1 
ATOM   2810 C CG  . PRO B 2 353 ? 42.56662 -0.13763  5.26597   1.000 42.27214  ? 351 PRO A CG  1 
ATOM   2811 C CD  . PRO B 2 353 ? 43.77182 -0.31498  4.39457   1.000 40.19214  ? 351 PRO A CD  1 
ATOM   2812 N N   . PRO B 2 354 ? 40.23017 1.98482   2.39811   1.000 48.84780  ? 352 PRO A N   1 
ATOM   2813 C CA  . PRO B 2 354 ? 39.77783 3.37864   2.29361   1.000 52.09780  ? 352 PRO A CA  1 
ATOM   2814 C C   . PRO B 2 354 ? 39.52285 3.99969   3.66139   1.000 56.67780  ? 352 PRO A C   1 
ATOM   2815 O O   . PRO B 2 354 ? 39.44512 3.31862   4.68833   1.000 47.12780  ? 352 PRO A O   1 
ATOM   2816 C CB  . PRO B 2 354 ? 38.48788 3.27217   1.47780   1.000 53.50780  ? 352 PRO A CB  1 
ATOM   2817 C CG  . PRO B 2 354 ? 38.04234 1.85513   1.65267   1.000 51.76780  ? 352 PRO A CG  1 
ATOM   2818 C CD  . PRO B 2 354 ? 39.29893 1.05407   1.73528   1.000 47.82780  ? 352 PRO A CD  1 
ATOM   2819 N N   . LEU B 2 355 ? 39.38068 5.32943   3.64191   1.000 58.86764  ? 353 LEU A N   1 
ATOM   2820 C CA  . LEU B 2 355 ? 39.23440 6.18565   4.83094   1.000 62.04764  ? 353 LEU A CA  1 
ATOM   2821 C C   . LEU B 2 355 ? 40.39393 6.00145   5.81154   1.000 61.75764  ? 353 LEU A C   1 
ATOM   2822 O O   . LEU B 2 355 ? 41.39885 6.71731   5.74815   1.000 56.74764  ? 353 LEU A O   1 
ATOM   2823 C CB  . LEU B 2 355 ? 37.89562 5.93545   5.54794   1.000 61.91764  ? 353 LEU A CB  1 
ATOM   2824 C CG  . LEU B 2 355 ? 36.66416 6.70405   5.05891   1.000 67.35764  ? 353 LEU A CG  1 
ATOM   2825 C CD1 . LEU B 2 355 ? 36.08399 6.10051   3.78083   1.000 63.27764  ? 353 LEU A CD1 1 
ATOM   2826 C CD2 . LEU B 2 355 ? 35.60880 6.78673   6.16321   1.000 64.19764  ? 353 LEU A CD2 1 
HETATM 2827 O O   . HOH C 3 .   ? 29.99838 -0.13610  37.83124  1.000 30.24371  ? 101 HOH B O   1 
HETATM 2828 O O   . HOH C 3 .   ? 26.48900 1.08412   36.25807  1.000 19.69071  ? 102 HOH B O   1 
HETATM 2829 O O   . HOH C 3 .   ? 31.94928 2.17050   28.77821  1.000 38.26855  ? 103 HOH B O   1 
HETATM 2830 O O   . HOH C 3 .   ? 37.63176 -4.85883  29.98366  1.000 44.10447  ? 104 HOH B O   1 
HETATM 2831 O O   . HOH C 3 .   ? 32.13723 0.93497   36.21411  1.000 36.78017  ? 105 HOH B O   1 
HETATM 2832 O O   . HOH C 3 .   ? 28.85238 1.01841   39.88739  1.000 21.40160  ? 106 HOH B O   1 
HETATM 2833 O O   . HOH C 3 .   ? 23.73130 -0.16163  35.62762  1.000 26.42310  ? 107 HOH B O   1 
HETATM 2834 O O   . HOH D 3 .   ? 42.68678 -4.98033  11.78645  1.000 30.20096  ? 401 HOH A O   1 
HETATM 2835 O O   . HOH D 3 .   ? 34.63578 -23.54272 3.30904   1.000 24.81413  ? 402 HOH A O   1 
HETATM 2836 O O   . HOH D 3 .   ? 55.66528 9.64902   19.05094  1.000 30.55397  ? 403 HOH A O   1 
HETATM 2837 O O   . HOH D 3 .   ? 59.36063 -13.85967 13.30405  1.000 37.32778  ? 404 HOH A O   1 
HETATM 2838 O O   . HOH D 3 .   ? 38.08939 -33.52979 35.67962  1.000 34.58121  ? 405 HOH A O   1 
HETATM 2839 O O   . HOH D 3 .   ? 52.18564 6.33493   -6.46710  1.000 38.07400  ? 406 HOH A O   1 
HETATM 2840 O O   . HOH D 3 .   ? 16.70718 -29.36004 20.25683  0.500 21.37540  ? 407 HOH A O   1 
HETATM 2841 O O   . HOH D 3 .   ? 43.93197 2.44572   -0.47844  1.000 36.10257  ? 408 HOH A O   1 
HETATM 2842 O O   . HOH D 3 .   ? 54.55484 -1.18906  -10.39620 1.000 27.51762  ? 409 HOH A O   1 
HETATM 2843 O O   . HOH D 3 .   ? 54.39279 -0.32477  -3.28756  1.000 34.83900  ? 410 HOH A O   1 
HETATM 2844 O O   . HOH D 3 .   ? 33.03973 -10.23916 1.06378   1.000 25.17084  ? 411 HOH A O   1 
HETATM 2845 O O   . HOH D 3 .   ? 37.72057 -35.46088 33.53771  1.000 31.64541  ? 412 HOH A O   1 
HETATM 2846 O O   . HOH D 3 .   ? 29.01616 -3.92440  36.31846  1.000 20.45957  ? 413 HOH A O   1 
HETATM 2847 O O   . HOH D 3 .   ? 20.17990 -27.12122 34.81402  1.000 29.17122  ? 414 HOH A O   1 
HETATM 2848 O O   . HOH D 3 .   ? 51.09974 1.34269   -15.46075 1.000 28.75554  ? 415 HOH A O   1 
HETATM 2849 O O   . HOH D 3 .   ? 61.15492 -2.07564  -4.03383  1.000 26.98568  ? 416 HOH A O   1 
HETATM 2850 O O   . HOH D 3 .   ? 47.93531 -20.80601 4.48914   1.000 25.00210  ? 417 HOH A O   1 
HETATM 2851 O O   . HOH D 3 .   ? 34.584   -18.597   32.994    1.000 28.11847  ? 418 HOH A O   1 
HETATM 2852 O O   . HOH D 3 .   ? 39.98042 -10.57137 -0.01282  1.000 19.12785  ? 419 HOH A O   1 
HETATM 2853 O O   . HOH D 3 .   ? 37.96788 -5.42289  10.62027  1.000 27.10411  ? 420 HOH A O   1 
HETATM 2854 O O   . HOH D 3 .   ? 41.42561 -38.98027 33.90674  1.000 31.13370  ? 421 HOH A O   1 
HETATM 2855 O O   . HOH D 3 .   ? 18.38299 -9.85153  27.31242  1.000 38.28740  ? 422 HOH A O   1 
HETATM 2856 O O   . HOH D 3 .   ? 60.74290 -7.58680  11.61043  1.000 22.85070  ? 423 HOH A O   1 
HETATM 2857 O O   . HOH D 3 .   ? 52.97815 -13.65075 -3.39502  1.000 16.42500  ? 424 HOH A O   1 
HETATM 2858 O O   . HOH D 3 .   ? 47.44480 -18.26269 5.04738   1.000 26.16971  ? 425 HOH A O   1 
HETATM 2859 O O   . HOH D 3 .   ? 29.07219 -23.42075 31.00101  1.000 21.14389  ? 426 HOH A O   1 
HETATM 2860 O O   . HOH D 3 .   ? 24.22387 -32.48165 20.26959  1.000 32.81308  ? 427 HOH A O   1 
HETATM 2861 O O   . HOH D 3 .   ? 24.56671 -30.41639 14.33915  1.000 14.87536  ? 428 HOH A O   1 
HETATM 2862 O O   . HOH D 3 .   ? 49.46065 -5.89446  14.46959  1.000 24.74551  ? 429 HOH A O   1 
HETATM 2863 O O   . HOH D 3 .   ? 37.83358 -23.58116 5.96322   1.000 29.09968  ? 430 HOH A O   1 
HETATM 2864 O O   . HOH D 3 .   ? 33.91360 -39.24403 30.32943  1.000 23.24309  ? 431 HOH A O   1 
HETATM 2865 O O   . HOH D 3 .   ? 65.18390 -0.16000  11.08808  1.000 30.89723  ? 432 HOH A O   1 
HETATM 2866 O O   . HOH D 3 .   ? 40.71581 -46.73350 29.18328  1.000 32.89418  ? 433 HOH A O   1 
HETATM 2867 O O   . HOH D 3 .   ? 49.80346 1.69046   3.69948   1.000 31.82399  ? 434 HOH A O   1 
HETATM 2868 O O   . HOH D 3 .   ? 24.15277 -16.15793 5.76738   1.000 26.43461  ? 435 HOH A O   1 
HETATM 2869 O O   . HOH D 3 .   ? 37.96894 -3.48602  19.79132  1.000 29.54251  ? 436 HOH A O   1 
HETATM 2870 O O   . HOH D 3 .   ? 52.46717 1.44630   3.90472   1.000 30.74088  ? 437 HOH A O   1 
HETATM 2871 O O   . HOH D 3 .   ? 34.12713 -36.65639 12.07198  1.000 39.95389  ? 438 HOH A O   1 
HETATM 2872 O O   . HOH D 3 .   ? 61.35882 12.59169  4.15596   1.000 37.79043  ? 439 HOH A O   1 
HETATM 2873 O O   . HOH D 3 .   ? 52.29659 -25.79990 4.82747   1.000 30.43955  ? 440 HOH A O   1 
HETATM 2874 O O   . HOH D 3 .   ? 61.07385 -8.87997  -4.56377  1.000 17.83570  ? 441 HOH A O   1 
HETATM 2875 O O   . HOH D 3 .   ? 41.86504 -21.37469 0.41258   1.000 22.92410  ? 442 HOH A O   1 
HETATM 2876 O O   . HOH D 3 .   ? 51.68024 -21.41700 -5.94081  1.000 23.92956  ? 443 HOH A O   1 
HETATM 2877 O O   . HOH D 3 .   ? 45.68011 -10.16283 16.03855  1.000 34.74880  ? 444 HOH A O   1 
HETATM 2878 O O   . HOH D 3 .   ? 53.01157 3.48834   6.37927   1.000 21.16004  ? 445 HOH A O   1 
HETATM 2879 O O   . HOH D 3 .   ? 25.10340 -11.42253 2.32250   1.000 24.39420  ? 446 HOH A O   1 
HETATM 2880 O O   . HOH D 3 .   ? 44.76006 -19.73808 10.25731  1.000 25.95065  ? 447 HOH A O   1 
HETATM 2881 O O   . HOH D 3 .   ? 44.34203 11.74669  7.68230   1.000 35.28220  ? 448 HOH A O   1 
HETATM 2882 O O   . HOH D 3 .   ? 26.64164 -24.66960 5.22058   1.000 20.98711  ? 449 HOH A O   1 
HETATM 2883 O O   . HOH D 3 .   ? 25.73689 -26.31773 32.47248  1.000 34.10545  ? 450 HOH A O   1 
HETATM 2884 O O   . HOH D 3 .   ? 23.137   -21.613   35.854    1.000 27.06031  ? 451 HOH A O   1 
HETATM 2885 O O   . HOH D 3 .   ? 43.30154 -29.41894 28.96786  1.000 30.91147  ? 452 HOH A O   1 
HETATM 2886 O O   . HOH D 3 .   ? 25.11415 -14.22353 30.10662  1.000 29.24864  ? 453 HOH A O   1 
HETATM 2887 O O   . HOH D 3 .   ? 45.89002 -13.25700 12.92013  1.000 32.88089  ? 454 HOH A O   1 
HETATM 2888 O O   . HOH D 3 .   ? 34.44720 -17.81835 -1.38447  1.000 31.37410  ? 455 HOH A O   1 
HETATM 2889 O O   . HOH D 3 .   ? 29.86377 -0.07026  13.19323  1.000 39.75812  ? 456 HOH A O   1 
HETATM 2890 O O   . HOH D 3 .   ? 43.07297 -7.02664  5.29354   1.000 13.58575  ? 457 HOH A O   1 
HETATM 2891 O O   . HOH D 3 .   ? 15.60242 -13.14053 11.05730  1.000 31.49954  ? 458 HOH A O   1 
HETATM 2892 O O   . HOH D 3 .   ? 30.49332 -27.17156 11.12010  1.000 20.97833  ? 459 HOH A O   1 
HETATM 2893 O O   . HOH D 3 .   ? 64.26605 5.61403   7.05220   1.000 35.81104  ? 460 HOH A O   1 
HETATM 2894 O O   . HOH D 3 .   ? 43.49692 -10.99809 24.50934  1.000 24.45623  ? 461 HOH A O   1 
HETATM 2895 O O   . HOH D 3 .   ? 57.77260 -25.63512 2.47520   1.000 31.89800  ? 462 HOH A O   1 
HETATM 2896 O O   . HOH D 3 .   ? 41.20677 -14.75845 -5.30264  1.000 23.99116  ? 463 HOH A O   1 
HETATM 2897 O O   . HOH D 3 .   ? 31.27325 -32.55186 31.17436  1.000 22.42669  ? 464 HOH A O   1 
HETATM 2898 O O   . HOH D 3 .   ? 18.60637 -16.44988 12.24577  1.000 12.98936  ? 465 HOH A O   1 
HETATM 2899 O O   . HOH D 3 .   ? 37.36442 -31.67771 12.46482  1.000 32.60549  ? 466 HOH A O   1 
HETATM 2900 O O   . HOH D 3 .   ? 32.99118 -30.14258 32.12982  1.000 24.87528  ? 467 HOH A O   1 
HETATM 2901 O O   . HOH D 3 .   ? 40.72982 -27.05830 35.71952  1.000 26.73287  ? 468 HOH A O   1 
HETATM 2902 O O   . HOH D 3 .   ? 35.25017 -25.20495 27.58374  1.000 18.88242  ? 469 HOH A O   1 
HETATM 2903 O O   . HOH D 3 .   ? 44.35341 -22.91560 -2.33029  1.000 18.98347  ? 470 HOH A O   1 
HETATM 2904 O O   . HOH D 3 .   ? 26.18189 -33.24878 21.49978  1.000 28.12771  ? 471 HOH A O   1 
HETATM 2905 O O   . HOH D 3 .   ? 33.37612 -8.74634  3.92677   1.000 14.94233  ? 472 HOH A O   1 
HETATM 2906 O O   . HOH D 3 .   ? 26.96954 -3.48015  31.09469  1.000 34.74885  ? 473 HOH A O   1 
HETATM 2907 O O   . HOH D 3 .   ? 48.25468 -12.94301 12.65292  1.000 28.50130  ? 474 HOH A O   1 
HETATM 2908 O O   . HOH D 3 .   ? 26.13344 -29.36427 9.06663   1.000 29.69707  ? 475 HOH A O   1 
HETATM 2909 O O   . HOH D 3 .   ? 68.91355 -7.96162  3.86212   1.000 39.05071  ? 476 HOH A O   1 
HETATM 2910 O O   . HOH D 3 .   ? 43.46867 -4.49732  4.47495   1.000 24.04410  ? 477 HOH A O   1 
HETATM 2911 O O   . HOH D 3 .   ? 63.37477 -22.60066 12.08687  1.000 36.02320  ? 478 HOH A O   1 
HETATM 2912 O O   . HOH D 3 .   ? 31.24975 -33.61194 34.57644  1.000 37.39845  ? 479 HOH A O   1 
HETATM 2913 O O   . HOH D 3 .   ? 13.40191 -17.82211 23.09778  1.000 30.17250  ? 480 HOH A O   1 
HETATM 2914 O O   . HOH D 3 .   ? 24.30521 -8.54496  9.55474   1.000 27.10453  ? 481 HOH A O   1 
HETATM 2915 O O   . HOH D 3 .   ? 16.161   -26.175   24.009    1.000 24.86232  ? 482 HOH A O   1 
HETATM 2916 O O   . HOH D 3 .   ? 41.50201 -23.93315 23.64675  1.000 26.14190  ? 483 HOH A O   1 
HETATM 2917 O O   . HOH D 3 .   ? 29.26193 -6.04406  13.88893  1.000 20.58828  ? 484 HOH A O   1 
HETATM 2918 O O   . HOH D 3 .   ? 48.06211 -34.22396 34.66111  1.000 39.75551  ? 485 HOH A O   1 
HETATM 2919 O O   . HOH D 3 .   ? 60.66086 -0.81713  0.00086   1.000 19.65554  ? 486 HOH A O   1 
HETATM 2920 O O   . HOH D 3 .   ? 26.92727 -1.74466  16.14837  1.000 33.42025  ? 487 HOH A O   1 
HETATM 2921 O O   . HOH D 3 .   ? 63.34110 -2.03609  11.65016  1.000 25.38261  ? 488 HOH A O   1 
HETATM 2922 O O   . HOH D 3 .   ? 31.12997 -15.86011 31.00498  1.000 22.26993  ? 489 HOH A O   1 
HETATM 2923 O O   . HOH D 3 .   ? 42.19248 -12.71373 28.31950  1.000 28.77333  ? 490 HOH A O   1 
HETATM 2924 O O   . HOH D 3 .   ? 43.56514 -3.51156  2.07702   1.000 32.10840  ? 491 HOH A O   1 
HETATM 2925 O O   . HOH D 3 .   ? 64.92422 8.85976   14.07906  1.000 30.77642  ? 492 HOH A O   1 
HETATM 2926 O O   . HOH D 3 .   ? 63.75185 -11.70496 -6.20500  1.000 32.19064  ? 493 HOH A O   1 
HETATM 2927 O O   . HOH D 3 .   ? 57.09947 -14.36366 11.27310  1.000 26.64826  ? 494 HOH A O   1 
HETATM 2928 O O   . HOH D 3 .   ? 23.03270 -18.47458 6.08667   1.000 26.87030  ? 495 HOH A O   1 
HETATM 2929 O O   . HOH D 3 .   ? 14.52881 -15.75329 18.41582  1.000 29.06387  ? 496 HOH A O   1 
HETATM 2930 O O   . HOH D 3 .   ? 54.97761 14.57419  -1.23454  1.000 33.91662  ? 497 HOH A O   1 
HETATM 2931 O O   . HOH D 3 .   ? 54.45459 -14.86088 11.27591  1.000 33.73895  ? 498 HOH A O   1 
HETATM 2932 O O   . HOH D 3 .   ? 33.77694 -22.75852 27.86286  1.000 13.96348  ? 499 HOH A O   1 
HETATM 2933 O O   . HOH D 3 .   ? 60.09259 4.55056   15.78373  1.000 27.84546  ? 500 HOH A O   1 
HETATM 2934 O O   . HOH D 3 .   ? 21.64456 -22.67987 33.19740  1.000 22.79458  ? 501 HOH A O   1 
HETATM 2935 O O   . HOH D 3 .   ? 31.35088 -23.15329 8.81005   1.000 8.79829   ? 502 HOH A O   1 
HETATM 2936 O O   . HOH D 3 .   ? 28.74874 -38.92691 20.88196  1.000 34.37946  ? 503 HOH A O   1 
HETATM 2937 O O   . HOH D 3 .   ? 54.63711 -12.19697 -3.47283  1.000 23.02670  ? 504 HOH A O   1 
HETATM 2938 O O   . HOH D 3 .   ? 57.87773 -6.29587  -5.78720  1.000 23.18670  ? 505 HOH A O   1 
HETATM 2939 O O   . HOH D 3 .   ? 27.13431 -39.26899 29.62352  1.000 33.73356  ? 506 HOH A O   1 
HETATM 2940 O O   . HOH D 3 .   ? 16.71200 -15.60898 20.33778  1.000 29.80766  ? 507 HOH A O   1 
HETATM 2941 O O   . HOH D 3 .   ? 54.41171 -0.35014  2.70749   1.000 21.86994  ? 508 HOH A O   1 
HETATM 2942 O O   . HOH D 3 .   ? 37.29863 -11.29535 0.45683   1.000 18.52860  ? 509 HOH A O   1 
HETATM 2943 O O   . HOH D 3 .   ? 29.86926 -29.97491 9.81576   1.000 28.01079  ? 510 HOH A O   1 
HETATM 2944 O O   . HOH D 3 .   ? 43.38776 -22.29091 7.34873   1.000 28.47643  ? 511 HOH A O   1 
HETATM 2945 O O   . HOH D 3 .   ? 40.89975 -24.84260 18.85286  1.000 25.14339  ? 512 HOH A O   1 
HETATM 2946 O O   . HOH D 3 .   ? 29.66949 -12.90009 6.69227   1.000 9.09608   ? 513 HOH A O   1 
HETATM 2947 O O   . HOH D 3 .   ? 33.21933 -5.24671  14.20209  1.000 26.76209  ? 514 HOH A O   1 
HETATM 2948 O O   . HOH D 3 .   ? 64.38578 -4.34174  -4.41803  1.000 32.85033  ? 515 HOH A O   1 
HETATM 2949 O O   . HOH D 3 .   ? 64.29474 -24.78621 0.37005   1.000 26.05190  ? 516 HOH A O   1 
HETATM 2950 O O   . HOH D 3 .   ? 56.41442 -22.08723 8.38576   1.000 24.59094  ? 517 HOH A O   1 
HETATM 2951 O O   . HOH D 3 .   ? 24.03023 -6.31899  33.37069  1.000 30.49467  ? 518 HOH A O   1 
HETATM 2952 O O   . HOH D 3 .   ? 54.07755 12.50885  19.68560  1.000 32.73988  ? 519 HOH A O   1 
HETATM 2953 O O   . HOH D 3 .   ? 46.72712 -12.82113 0.06263   1.000 11.32414  ? 520 HOH A O   1 
HETATM 2954 O O   . HOH D 3 .   ? 54.85862 -6.46088  -5.71680  1.000 17.05144  ? 521 HOH A O   1 
HETATM 2955 O O   . HOH D 3 .   ? 53.48763 -0.77251  0.47204   1.000 26.60520  ? 522 HOH A O   1 
HETATM 2956 O O   . HOH D 3 .   ? 66.21142 -22.76560 7.12410   1.000 24.05986  ? 523 HOH A O   1 
HETATM 2957 O O   . HOH D 3 .   ? 16.422   -17.908   9.570     1.000 30.56157  ? 524 HOH A O   1 
HETATM 2958 O O   . HOH D 3 .   ? 65.48859 -12.05774 -1.19717  1.000 29.63906  ? 525 HOH A O   1 
HETATM 2959 O O   . HOH D 3 .   ? 33.84915 -13.39725 -3.73780  1.000 33.40640  ? 526 HOH A O   1 
HETATM 2960 O O   . HOH D 3 .   ? 38.94355 -4.43337  22.21111  1.000 30.44677  ? 527 HOH A O   1 
HETATM 2961 O O   . HOH D 3 .   ? 38.94387 -17.96734 28.69512  1.000 26.46349  ? 528 HOH A O   1 
HETATM 2962 O O   . HOH D 3 .   ? 53.08876 -18.51458 -4.08197  1.000 23.26959  ? 529 HOH A O   1 
HETATM 2963 O O   . HOH D 3 .   ? 45.17139 -6.20251  1.77436   1.000 24.40053  ? 530 HOH A O   1 
HETATM 2964 O O   . HOH D 3 .   ? 38.74420 -26.38786 18.00806  1.000 19.76943  ? 531 HOH A O   1 
HETATM 2965 O O   . HOH D 3 .   ? 21.22333 -10.37347 32.82293  1.000 28.95121  ? 532 HOH A O   1 
HETATM 2966 O O   . HOH D 3 .   ? 46.63394 -23.91444 5.14302   1.000 36.67587  ? 533 HOH A O   1 
HETATM 2967 O O   . HOH D 3 .   ? 59.89017 -23.85339 1.78088   1.000 17.65765  ? 534 HOH A O   1 
HETATM 2968 O O   . HOH D 3 .   ? 60.50198 2.06889   3.01087   1.000 17.28399  ? 535 HOH A O   1 
HETATM 2969 O O   . HOH D 3 .   ? 31.18457 -20.30293 4.98181   1.000 8.81368   ? 536 HOH A O   1 
HETATM 2970 O O   . HOH D 3 .   ? 49.60493 4.87461   22.34060  1.000 37.60629  ? 537 HOH A O   1 
HETATM 2971 O O   . HOH D 3 .   ? 19.24516 -11.62925 29.78463  1.000 34.33305  ? 538 HOH A O   1 
HETATM 2972 O O   . HOH D 3 .   ? 21.28215 -5.45192  4.22057   1.000 34.13536  ? 539 HOH A O   1 
HETATM 2973 O O   . HOH D 3 .   ? 49.957   11.386    9.389     1.000 29.38834  ? 540 HOH A O   1 
HETATM 2974 O O   . HOH D 3 .   ? 46.13431 -18.03457 17.87836  1.000 32.53857  ? 541 HOH A O   1 
HETATM 2975 O O   . HOH D 3 .   ? 44.54070 -13.43195 -1.57404  1.000 20.89864  ? 542 HOH A O   1 
HETATM 2976 O O   . HOH D 3 .   ? 55.35559 -12.24838 -5.94679  1.000 31.89399  ? 543 HOH A O   1 
HETATM 2977 O O   . HOH D 3 .   ? 40.79926 -22.91690 20.78567  1.000 21.96599  ? 544 HOH A O   1 
HETATM 2978 O O   . HOH D 3 .   ? 37.64575 -2.51017  24.09385  1.000 36.67690  ? 545 HOH A O   1 
HETATM 2979 O O   . HOH D 3 .   ? 39.31335 -20.22132 -1.25776  1.000 29.08145  ? 546 HOH A O   1 
HETATM 2980 O O   . HOH D 3 .   ? 28.14732 -39.96354 13.70198  1.000 40.50563  ? 547 HOH A O   1 
HETATM 2981 O O   . HOH D 3 .   ? 26.01702 -2.27108  18.43438  1.000 30.22351  ? 548 HOH A O   1 
HETATM 2982 O O   . HOH D 3 .   ? 55.96049 11.00218  6.59243   1.000 26.30154  ? 549 HOH A O   1 
HETATM 2983 O O   . HOH D 3 .   ? 45.38341 -7.14616  16.18222  1.000 32.65428  ? 550 HOH A O   1 
HETATM 2984 O O   . HOH D 3 .   ? 46.28525 -4.96572  -0.66591  1.000 22.14896  ? 551 HOH A O   1 
HETATM 2985 O O   . HOH D 3 .   ? 17.00301 -13.16365 17.98971  1.000 28.33906  ? 552 HOH A O   1 
HETATM 2986 O O   . HOH D 3 .   ? 61.03322 8.81190   2.84054   1.000 29.98184  ? 553 HOH A O   1 
HETATM 2987 O O   . HOH D 3 .   ? 64.27051 -3.76170  6.82002   1.000 25.54067  ? 554 HOH A O   1 
HETATM 2988 O O   . HOH D 3 .   ? 48.72528 -30.65844 31.78049  1.000 36.43702  ? 555 HOH A O   1 
HETATM 2989 O O   . HOH D 3 .   ? 45.18492 2.21929   7.61118   1.000 30.17168  ? 556 HOH A O   1 
HETATM 2990 O O   . HOH D 3 .   ? 39.04574 -7.67665  7.90947   1.000 11.20396  ? 557 HOH A O   1 
HETATM 2991 O O   . HOH D 3 .   ? 33.14649 -15.67784 -3.34286  1.000 29.52662  ? 558 HOH A O   1 
HETATM 2992 O O   . HOH D 3 .   ? 39.11738 -22.81771 16.91839  1.000 15.01715  ? 559 HOH A O   1 
HETATM 2993 O O   . HOH D 3 .   ? 55.37964 -16.77608 -7.14134  1.000 25.11259  ? 560 HOH A O   1 
HETATM 2994 O O   . HOH D 3 .   ? 64.76098 6.82243   10.75054  1.000 35.90367  ? 561 HOH A O   1 
HETATM 2995 O O   . HOH D 3 .   ? 36.88251 -28.25832 24.26679  1.000 15.75501  ? 562 HOH A O   1 
HETATM 2996 O O   . HOH D 3 .   ? 48.63053 -14.76917 14.61356  1.000 38.26994  ? 563 HOH A O   1 
HETATM 2997 O O   . HOH D 3 .   ? 47.78879 2.26329   5.46038   1.000 29.65428  ? 564 HOH A O   1 
HETATM 2998 O O   . HOH D 3 .   ? 40.39581 -37.10368 34.76428  1.000 35.82393  ? 565 HOH A O   1 
HETATM 2999 O O   . HOH D 3 .   ? 66.13050 -21.32131 -6.67836  1.000 21.14780  ? 566 HOH A O   1 
HETATM 3000 O O   . HOH D 3 .   ? 50.79570 2.44655   -5.09562  1.000 47.55968  ? 567 HOH A O   1 
HETATM 3001 O O   . HOH D 3 .   ? 25.56282 -16.07636 33.40267  1.000 25.17096  ? 568 HOH A O   1 
HETATM 3002 O O   . HOH D 3 .   ? 44.487   -15.443   -3.142    1.000 21.49155  ? 569 HOH A O   1 
HETATM 3003 O O   . HOH D 3 .   ? 47.87565 -6.59705  -2.83574  1.000 25.51348  ? 570 HOH A O   1 
HETATM 3004 O O   . HOH D 3 .   ? 23.64978 -32.78991 11.66368  1.000 28.53643  ? 571 HOH A O   1 
HETATM 3005 O O   . HOH D 3 .   ? 47.85984 -10.91255 -1.29942  1.000 14.46159  ? 572 HOH A O   1 
HETATM 3006 O O   . HOH D 3 .   ? 27.61158 -35.80492 20.33503  1.000 29.75980  ? 573 HOH A O   1 
HETATM 3007 O O   . HOH D 3 .   ? 29.19289 -12.12148 -0.42699  1.000 22.98448  ? 574 HOH A O   1 
HETATM 3008 O O   . HOH D 3 .   ? 60.28457 -7.93926  17.38404  1.000 30.74735  ? 575 HOH A O   1 
HETATM 3009 O O   . HOH D 3 .   ? 35.62356 -7.18583  1.39387   1.000 33.46451  ? 576 HOH A O   1 
HETATM 3010 O O   . HOH D 3 .   ? 35.81140 -4.82907  18.28709  1.000 23.26539  ? 577 HOH A O   1 
HETATM 3011 O O   . HOH D 3 .   ? 14.88046 -15.48925 21.74459  1.000 38.67797  ? 578 HOH A O   1 
HETATM 3012 O O   . HOH D 3 .   ? 49.55681 -18.76796 -3.38374  1.000 14.49123  ? 579 HOH A O   1 
HETATM 3013 O O   . HOH D 3 .   ? 46.14980 -6.09273  19.54969  1.000 36.67204  ? 580 HOH A O   1 
HETATM 3014 O O   . HOH D 3 .   ? 37.74327 -21.11740 34.41796  1.000 27.24588  ? 581 HOH A O   1 
HETATM 3015 O O   . HOH D 3 .   ? 59.07973 -0.73041  -11.54073 1.000 37.26204  ? 582 HOH A O   1 
HETATM 3016 O O   . HOH D 3 .   ? 69.70979 -16.46547 2.19965   1.000 34.62445  ? 583 HOH A O   1 
HETATM 3017 O O   . HOH D 3 .   ? 51.59165 5.63282   6.05976   1.000 24.70548  ? 584 HOH A O   1 
HETATM 3018 O O   . HOH D 3 .   ? 40.71894 -17.21427 26.41135  1.000 20.62489  ? 585 HOH A O   1 
HETATM 3019 O O   . HOH D 3 .   ? 34.79781 -3.15740  25.53932  1.000 32.80101  ? 586 HOH A O   1 
HETATM 3020 O O   . HOH D 3 .   ? 62.94715 8.36168   6.49800   1.000 25.85183  ? 587 HOH A O   1 
HETATM 3021 O O   . HOH D 3 .   ? 35.20097 1.05593   22.43039  1.000 37.39679  ? 588 HOH A O   1 
HETATM 3022 O O   . HOH D 3 .   ? 29.09535 -14.35869 31.14716  1.000 17.85464  ? 589 HOH A O   1 
HETATM 3023 O O   . HOH D 3 .   ? 65.36321 -12.22315 9.89563   1.000 32.10498  ? 590 HOH A O   1 
HETATM 3024 O O   . HOH D 3 .   ? 68.40179 -17.96714 0.35287   1.000 20.38022  ? 591 HOH A O   1 
HETATM 3025 O O   . HOH D 3 .   ? 13.52583 -34.40633 28.44038  1.000 19.94966  ? 592 HOH A O   1 
HETATM 3026 O O   . HOH D 3 .   ? 64.20527 -25.01234 -2.55810  1.000 28.61803  ? 593 HOH A O   1 
HETATM 3027 O O   . HOH D 3 .   ? 20.38138 -5.68291  26.71099  1.000 42.09649  ? 594 HOH A O   1 
HETATM 3028 O O   . HOH D 3 .   ? 33.38106 -11.43585 -1.92841  1.000 30.78890  ? 595 HOH A O   1 
HETATM 3029 O O   . HOH D 3 .   ? 56.98754 -0.15249  3.31975   1.000 18.77904  ? 596 HOH A O   1 
HETATM 3030 O O   . HOH D 3 .   ? 43.93322 -8.93574  -1.03312  1.000 27.50309  ? 597 HOH A O   1 
HETATM 3031 O O   . HOH D 3 .   ? 32.06620 -7.17143  6.17250   1.000 24.35778  ? 598 HOH A O   1 
HETATM 3032 O O   . HOH D 3 .   ? 23.21600 -24.37250 34.27010  1.000 31.84028  ? 599 HOH A O   1 
HETATM 3033 O O   . HOH D 3 .   ? 32.615   -25.638   35.290    1.000 24.37635  ? 600 HOH A O   1 
HETATM 3034 O O   . HOH D 3 .   ? 36.71848 -13.84227 32.29361  1.000 32.51360  ? 601 HOH A O   1 
HETATM 3035 O O   . HOH D 3 .   ? 35.05532 -35.46977 14.57562  1.000 32.28075  ? 602 HOH A O   1 
HETATM 3036 O O   . HOH D 3 .   ? 28.46999 -25.28416 32.49196  1.000 27.20673  ? 603 HOH A O   1 
HETATM 3037 O O   . HOH D 3 .   ? 29.85351 -21.87380 6.76190   1.000 11.29667  ? 604 HOH A O   1 
HETATM 3038 O O   . HOH D 3 .   ? 28.27458 -37.06982 17.25890  1.000 25.89525  ? 605 HOH A O   1 
HETATM 3039 O O   . HOH D 3 .   ? 27.06070 -46.36736 16.45763  1.000 45.55146  ? 606 HOH A O   1 
HETATM 3040 O O   . HOH D 3 .   ? 34.12155 -28.62282 5.98992   1.000 33.75041  ? 607 HOH A O   1 
HETATM 3041 O O   . HOH D 3 .   ? 32.39453 -22.63177 4.12949   1.000 18.22492  ? 608 HOH A O   1 
HETATM 3042 O O   . HOH D 3 .   ? 40.33035 -51.52470 22.69920  1.000 38.09016  ? 609 HOH A O   1 
HETATM 3043 O O   . HOH D 3 .   ? 39.42255 7.59280   9.97061   1.000 38.90322  ? 610 HOH A O   1 
HETATM 3044 O O   . HOH D 3 .   ? 24.79721 -5.45596  30.91601  1.000 31.07765  ? 611 HOH A O   1 
HETATM 3045 O O   . HOH D 3 .   ? 67.32863 -21.75303 2.15933   1.000 18.43018  ? 612 HOH A O   1 
HETATM 3046 O O   . HOH D 3 .   ? 54.02268 9.23123   7.80470   1.000 19.19177  ? 613 HOH A O   1 
HETATM 3047 O O   . HOH D 3 .   ? 20.03398 -17.39754 27.84670  1.000 27.65438  ? 614 HOH A O   1 
HETATM 3048 O O   . HOH D 3 .   ? 27.690   -12.707   32.280    1.000 21.82904  ? 615 HOH A O   1 
HETATM 3049 O O   . HOH D 3 .   ? 64.43648 -23.83007 8.22219   1.000 29.58162  ? 616 HOH A O   1 
HETATM 3050 O O   . HOH D 3 .   ? 55.81605 -27.97759 1.45503   1.000 31.77051  ? 617 HOH A O   1 
HETATM 3051 O O   . HOH D 3 .   ? 43.23419 -17.54037 27.06444  1.000 34.31017  ? 618 HOH A O   1 
HETATM 3052 O O   . HOH D 3 .   ? 30.33314 -27.26587 32.91618  1.000 27.43663  ? 619 HOH A O   1 
HETATM 3053 O O   . HOH D 3 .   ? 54.95020 -25.15284 6.16827   1.000 31.50723  ? 620 HOH A O   1 
HETATM 3054 O O   . HOH D 3 .   ? 33.38470 -25.77350 3.25588   1.000 33.02202  ? 621 HOH A O   1 
HETATM 3055 O O   . HOH D 3 .   ? 25.19925 -13.88416 32.79078  1.000 27.78258  ? 622 HOH A O   1 
HETATM 3056 O O   . HOH D 3 .   ? 23.60185 -29.29070 10.22062  1.000 31.15138  ? 623 HOH A O   1 
HETATM 3057 O O   . HOH D 3 .   ? 47.56008 -20.49661 17.94424  1.000 36.89224  ? 624 HOH A O   1 
HETATM 3058 O O   . HOH D 3 .   ? 54.98889 -22.75804 10.99338  1.000 40.79026  ? 625 HOH A O   1 
HETATM 3059 O O   . HOH D 3 .   ? 63.23767 -27.39830 -3.44873  1.000 37.64730  ? 626 HOH A O   1 
HETATM 3060 O O   . HOH D 3 .   ? 30.91229 -25.97115 4.53795   1.000 31.32972  ? 627 HOH A O   1 
HETATM 3061 O O   . HOH D 3 .   ? 42.47457 -2.59245  -0.84620  1.000 38.40893  ? 628 HOH A O   1 
HETATM 3062 O O   . HOH D 3 .   ? 52.55754 -24.00441 -6.00036  1.000 27.63468  ? 629 HOH A O   1 
HETATM 3063 O O   . HOH D 3 .   ? 31.77837 -25.71986 8.90675   1.000 27.04204  ? 630 HOH A O   1 
HETATM 3064 O O   . HOH D 3 .   ? 15.10060 -12.76724 22.67058  1.000 38.81957  ? 631 HOH A O   1 
HETATM 3065 O O   . HOH D 3 .   ? 22.45005 -8.17356  33.53827  1.000 27.58868  ? 632 HOH A O   1 
HETATM 3066 O O   . HOH D 3 .   ? 41.20460 -10.65969 -2.62561  1.000 33.25395  ? 633 HOH A O   1 
HETATM 3067 O O   . HOH D 3 .   ? 22.22174 -20.25185 31.57592  1.000 34.48855  ? 634 HOH A O   1 
HETATM 3068 O O   . HOH D 3 .   ? 41.71387 -3.44026  6.94080   1.000 29.39147  ? 635 HOH A O   1 
HETATM 3069 O O   . HOH D 3 .   ? 26.82787 -27.32128 4.30640   1.000 32.44077  ? 636 HOH A O   1 
HETATM 3070 O O   . HOH D 3 .   ? 43.25146 -31.81152 38.21778  1.000 31.26065  ? 637 HOH A O   1 
HETATM 3071 O O   . HOH D 3 .   ? 25.40519 -27.94519 34.96256  1.000 38.80121  ? 638 HOH A O   1 
HETATM 3072 O O   . HOH D 3 .   ? 57.06903 0.97671   -2.96662  1.000 34.48918  ? 639 HOH A O   1 
HETATM 3073 O O   . HOH D 3 .   ? 55.70873 -8.77561  -7.73170  1.000 30.96685  ? 640 HOH A O   1 
HETATM 3074 O O   . HOH D 3 .   ? 28.89237 -23.72717 4.90402   1.000 20.65668  ? 641 HOH A O   1 
HETATM 3075 O O   . HOH D 3 .   ? 28.89676 -41.61680 15.39948  1.000 42.17048  ? 642 HOH A O   1 
HETATM 3076 O O   . HOH D 3 .   ? 36.40342 -3.88745  8.53672   1.000 33.86930  ? 643 HOH A O   1 
HETATM 3077 O O   . HOH D 3 .   ? 21.31586 -17.81820 30.08123  1.000 32.05823  ? 644 HOH A O   1 
HETATM 3078 O O   . HOH D 3 .   ? 49.06401 -8.79102  13.31757  1.000 30.71743  ? 645 HOH A O   1 
HETATM 3079 O O   . HOH D 3 .   ? 26.17958 -7.16141  11.27616  1.000 34.46033  ? 646 HOH A O   1 
HETATM 3080 O O   . HOH D 3 .   ? 49.23057 -7.15016  16.61936  1.000 35.20520  ? 647 HOH A O   1 
HETATM 3081 O O   . HOH D 3 .   ? 52.54047 11.55624  8.54580   1.000 30.67848  ? 648 HOH A O   1 
HETATM 3082 O O   . HOH D 3 .   ? 20.36269 -18.33183 5.39539   1.000 35.84453  ? 649 HOH A O   1 
HETATM 3083 O O   . HOH D 3 .   ? 64.46608 -14.98621 -4.75386  1.000 30.48991  ? 650 HOH A O   1 
HETATM 3084 O O   . HOH D 3 .   ? 42.28006 -23.63237 -0.42403  1.000 31.88068  ? 651 HOH A O   1 
HETATM 3085 O O   . HOH D 3 .   ? 12.43444 -16.73647 16.70413  1.000 40.74667  ? 652 HOH A O   1 
HETATM 3086 O O   . HOH D 3 .   ? 39.10408 -25.49493 5.03989   1.000 30.04719  ? 653 HOH A O   1 
HETATM 3087 O O   . HOH D 3 .   ? 31.89692 -27.91978 7.10544   1.000 32.33991  ? 654 HOH A O   1 
HETATM 3088 O O   . HOH D 3 .   ? 35.66014 -9.32815  0.54665   1.000 29.08924  ? 655 HOH A O   1 
HETATM 3089 O O   . HOH D 3 .   ? 38.16961 -1.00635  19.74028  1.000 34.11038  ? 656 HOH A O   1 
HETATM 3090 O O   . HOH D 3 .   ? 57.36134 2.46625   3.27958   1.000 24.21257  ? 657 HOH A O   1 
HETATM 3091 O O   . HOH D 3 .   ? 16.746   -30.020   34.994    1.000 39.33733  ? 658 HOH A O   1 
HETATM 3092 O O   . HOH D 3 .   ? 40.39932 -3.65478  11.28911  1.000 32.65223  ? 659 HOH A O   1 
HETATM 3093 O O   . HOH D 3 .   ? 40.99486 -21.38236 -4.31806  1.000 33.96426  ? 660 HOH A O   1 
HETATM 3094 O O   . HOH D 3 .   ? 49.83851 9.95422   -3.71556  1.000 37.63982  ? 661 HOH A O   1 
HETATM 3095 O O   . HOH D 3 .   ? 32.11546 -18.87719 -1.21982  1.000 33.28365  ? 662 HOH A O   1 
HETATM 3096 O O   . HOH D 3 .   ? 56.45323 3.08410   1.02565   1.000 35.06619  ? 663 HOH A O   1 
HETATM 3097 O O   . HOH D 3 .   ? 69.31482 -17.43138 -2.31102  1.000 32.16098  ? 664 HOH A O   1 
HETATM 3098 O O   . HOH D 3 .   ? 16.389   -35.884   24.920    1.000 26.64040  ? 665 HOH A O   1 
HETATM 3099 O O   . HOH D 3 .   ? 59.966   3.339     -12.277   1.000 30.04286  ? 666 HOH A O   1 
HETATM 3100 O O   . HOH D 3 .   ? 58.17878 -4.31541  23.19815  1.000 48.51710  ? 667 HOH A O   1 
HETATM 3101 O O   . HOH D 3 .   ? 49.77168 -24.53589 8.02557   1.000 40.07998  ? 668 HOH A O   1 
HETATM 3102 O O   . HOH D 3 .   ? 40.55651 -30.88026 37.73551  1.000 36.30154  ? 669 HOH A O   1 
HETATM 3103 O O   . HOH D 3 .   ? 25.80244 -26.44149 38.00136  1.000 28.81484  ? 670 HOH A O   1 
HETATM 3104 O O   . HOH D 3 .   ? 16.14582 -16.15810 11.26525  1.000 22.36972  ? 671 HOH A O   1 
HETATM 3105 O O   . HOH D 3 .   ? 27.52440 -29.64532 6.22007   1.000 35.67215  ? 672 HOH A O   1 
HETATM 3106 O O   . HOH D 3 .   ? 14.90135 -17.68184 34.21604  1.000 33.45934  ? 673 HOH A O   1 
HETATM 3107 O O   . HOH D 3 .   ? 41.55598 0.21836   14.12294  1.000 31.95878  ? 674 HOH A O   1 
HETATM 3108 O O   . HOH D 3 .   ? 31.38629 -8.81410  -0.40765  1.000 30.11810  ? 675 HOH A O   1 
HETATM 3109 O O   . HOH D 3 .   ? 69.32520 -20.43315 1.12701   1.000 16.13130  ? 676 HOH A O   1 
HETATM 3110 O O   . HOH D 3 .   ? 30.10983 -29.71477 7.49910   1.000 25.51466  ? 677 HOH A O   1 
HETATM 3111 O O   . HOH D 3 .   ? 59.28658 0.11591   -13.76383 1.000 36.06924  ? 678 HOH A O   1 
HETATM 3112 O O   . HOH D 3 .   ? 67.40699 -17.33903 -5.30575  1.000 38.14098  ? 679 HOH A O   1 
HETATM 3113 O O   . HOH D 3 .   ? 68.09017 -19.58609 -6.55234  1.000 26.14262  ? 680 HOH A O   1 
HETATM 3114 O O   . HOH D 3 .   ? 58.22329 -0.78036  0.95842   1.000 27.44022  ? 681 HOH A O   1 
HETATM 3115 O O   . HOH D 3 .   ? 45.67362 -12.54326 25.51253  1.000 33.61186  ? 682 HOH A O   1 
HETATM 3116 O O   . HOH D 3 .   ? 43.22313 -22.66693 -4.60192  1.000 32.22410  ? 683 HOH A O   1 
HETATM 3117 O O   . HOH D 3 .   ? 29.41901 -19.88379 2.87948   1.000 18.71789  ? 684 HOH A O   1 
HETATM 3118 O O   . HOH D 3 .   ? 26.684   -38.427   15.180    1.000 39.07300  ? 685 HOH A O   1 
HETATM 3119 O O   . HOH D 3 .   ? 49.95882 9.64897   6.89594   1.000 36.28168  ? 686 HOH A O   1 
HETATM 3120 O O   . HOH D 3 .   ? 56.18425 0.24488   -0.54525  1.000 28.00984  ? 687 HOH A O   1 
HETATM 3121 O O   . HOH D 3 .   ? 54.70862 2.85156   4.08795   1.000 31.22936  ? 688 HOH A O   1 
HETATM 3122 O O   . HOH D 3 .   ? 12.06471 -16.97574 14.02515  1.000 35.64588  ? 689 HOH A O   1 
HETATM 3123 O O   . HOH D 3 .   ? 52.44402 8.31291   6.27483   1.000 19.24198  ? 690 HOH A O   1 
HETATM 3124 O O   . HOH D 3 .   ? 30.55305 -20.06594 0.37513   1.000 28.57637  ? 691 HOH A O   1 
HETATM 3125 O O   . HOH D 3 .   ? 46.50154 -38.34857 36.42779  1.000 39.75362  ? 692 HOH A O   1 
HETATM 3126 O O   . HOH D 3 .   ? 63.66315 -26.29122 6.64999   1.000 39.30275  ? 693 HOH A O   1 
HETATM 3127 O O   . HOH D 3 .   ? 12.11041 -16.62869 21.18864  1.000 39.73899  ? 694 HOH A O   1 
HETATM 3128 O O   . HOH D 3 .   ? 30.26999 -5.89483  2.82992   1.000 33.27560  ? 695 HOH A O   1 
HETATM 3129 O O   . HOH D 3 .   ? 70.93796 -19.37932 3.14320   1.000 29.59696  ? 696 HOH A O   1 
HETATM 3130 O O   . HOH D 3 .   ? 41.91746 -25.25854 -4.66094  1.000 31.03197  ? 697 HOH A O   1 
# 
