data_8YP8
# 
_entry.id   8YP8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YP8         pdb_00008yp8 10.2210/pdb8yp8/pdb 
WWPDB D_1300044997 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-19 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YP8 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 jiaweiwu@suda.edu.cn            Jia-Wei Wu   ? 'principal investigator/group leader' 0000-0003-0273-1686 
3 zhixinwang@mail.tsinghua.edu.cn Zhi-Xin Wang ? 'principal investigator/group leader' 0000-0003-4656-2941 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, Y.Y.' 1 ? 
'Pei, C.J.'   2 ? 
'He, Q.Q.'    3 ? 
'Luo, Z.P.'   4 ? 
'Wu, J.W.'    5 ? 
'Wang, Z.X.'  6 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural and mechanistic insights into the allosteric activation of p38alpha MAP kinase via specific docking interactions' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, Y.Y.' 1 ? 
primary 'Pei, C.J.'   2 ? 
primary 'He, Q.Q.'    3 ? 
primary 'Luo, Z.P.'   4 ? 
primary 'Wu, J.W.'    5 ? 
primary 'Wang, Z.X.'  6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Mitogen-activated protein kinase 14'              43378.312 1   2.7.11.24 ?    ? ? 
2 polymer syn 'Tyrosine-protein phosphatase non-receptor type 7' 1864.180  1   3.1.3.48  V31C ? ? 
3 water   nat water                                              18.015    221 ?         ?    ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'MAP kinase 14,MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha'                          
2 'KIM peptide derived from HePTP,Hematopoietic protein-tyrosine phosphatase,HEPTP,Protein-tyrosine phosphatase LC-PTP' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSSHHHHHHSSGLVPRGSHMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQS
IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI
HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT
LFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ
ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
;GSSHHHHHHSSGLVPRGSHMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQS
IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI
HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT
LFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ
ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
A ? 
2 'polypeptide(L)' no no RLQERRGSNVALMLDC RLQERRGSNVALMLDC B ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   SER n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  SER n 
1 11  SER n 
1 12  GLY n 
1 13  LEU n 
1 14  VAL n 
1 15  PRO n 
1 16  ARG n 
1 17  GLY n 
1 18  SER n 
1 19  HIS n 
1 20  MET n 
1 21  SER n 
1 22  GLN n 
1 23  GLU n 
1 24  ARG n 
1 25  PRO n 
1 26  THR n 
1 27  PHE n 
1 28  TYR n 
1 29  ARG n 
1 30  GLN n 
1 31  GLU n 
1 32  LEU n 
1 33  ASN n 
1 34  LYS n 
1 35  THR n 
1 36  ILE n 
1 37  TRP n 
1 38  GLU n 
1 39  VAL n 
1 40  PRO n 
1 41  GLU n 
1 42  ARG n 
1 43  TYR n 
1 44  GLN n 
1 45  ASN n 
1 46  LEU n 
1 47  SER n 
1 48  PRO n 
1 49  VAL n 
1 50  GLY n 
1 51  SER n 
1 52  GLY n 
1 53  ALA n 
1 54  TYR n 
1 55  GLY n 
1 56  SER n 
1 57  VAL n 
1 58  CYS n 
1 59  ALA n 
1 60  ALA n 
1 61  PHE n 
1 62  ASP n 
1 63  THR n 
1 64  LYS n 
1 65  THR n 
1 66  GLY n 
1 67  HIS n 
1 68  ARG n 
1 69  VAL n 
1 70  ALA n 
1 71  VAL n 
1 72  LYS n 
1 73  LYS n 
1 74  LEU n 
1 75  SER n 
1 76  ARG n 
1 77  PRO n 
1 78  PHE n 
1 79  GLN n 
1 80  SER n 
1 81  ILE n 
1 82  ILE n 
1 83  HIS n 
1 84  ALA n 
1 85  LYS n 
1 86  ARG n 
1 87  THR n 
1 88  TYR n 
1 89  ARG n 
1 90  GLU n 
1 91  LEU n 
1 92  ARG n 
1 93  LEU n 
1 94  LEU n 
1 95  LYS n 
1 96  HIS n 
1 97  MET n 
1 98  LYS n 
1 99  HIS n 
1 100 GLU n 
1 101 ASN n 
1 102 VAL n 
1 103 ILE n 
1 104 GLY n 
1 105 LEU n 
1 106 LEU n 
1 107 ASP n 
1 108 VAL n 
1 109 PHE n 
1 110 THR n 
1 111 PRO n 
1 112 ALA n 
1 113 ARG n 
1 114 SER n 
1 115 LEU n 
1 116 GLU n 
1 117 GLU n 
1 118 PHE n 
1 119 ASN n 
1 120 ASP n 
1 121 VAL n 
1 122 TYR n 
1 123 LEU n 
1 124 VAL n 
1 125 THR n 
1 126 HIS n 
1 127 LEU n 
1 128 MET n 
1 129 GLY n 
1 130 ALA n 
1 131 ASP n 
1 132 LEU n 
1 133 ASN n 
1 134 ASN n 
1 135 ILE n 
1 136 VAL n 
1 137 LYS n 
1 138 CYS n 
1 139 GLN n 
1 140 LYS n 
1 141 LEU n 
1 142 THR n 
1 143 ASP n 
1 144 ASP n 
1 145 HIS n 
1 146 VAL n 
1 147 GLN n 
1 148 PHE n 
1 149 LEU n 
1 150 ILE n 
1 151 TYR n 
1 152 GLN n 
1 153 ILE n 
1 154 LEU n 
1 155 ARG n 
1 156 GLY n 
1 157 LEU n 
1 158 LYS n 
1 159 TYR n 
1 160 ILE n 
1 161 HIS n 
1 162 SER n 
1 163 ALA n 
1 164 ASP n 
1 165 ILE n 
1 166 ILE n 
1 167 HIS n 
1 168 ARG n 
1 169 ASP n 
1 170 LEU n 
1 171 LYS n 
1 172 PRO n 
1 173 SER n 
1 174 ASN n 
1 175 LEU n 
1 176 ALA n 
1 177 VAL n 
1 178 ASN n 
1 179 GLU n 
1 180 ASP n 
1 181 CYS n 
1 182 GLU n 
1 183 LEU n 
1 184 LYS n 
1 185 ILE n 
1 186 LEU n 
1 187 ASP n 
1 188 PHE n 
1 189 GLY n 
1 190 LEU n 
1 191 ALA n 
1 192 ARG n 
1 193 HIS n 
1 194 THR n 
1 195 ASP n 
1 196 ASP n 
1 197 GLU n 
1 198 MET n 
1 199 THR n 
1 200 GLY n 
1 201 TYR n 
1 202 VAL n 
1 203 ALA n 
1 204 THR n 
1 205 ARG n 
1 206 TRP n 
1 207 TYR n 
1 208 ARG n 
1 209 ALA n 
1 210 PRO n 
1 211 GLU n 
1 212 ILE n 
1 213 MET n 
1 214 LEU n 
1 215 ASN n 
1 216 TRP n 
1 217 MET n 
1 218 HIS n 
1 219 TYR n 
1 220 ASN n 
1 221 GLN n 
1 222 THR n 
1 223 VAL n 
1 224 ASP n 
1 225 ILE n 
1 226 TRP n 
1 227 SER n 
1 228 VAL n 
1 229 GLY n 
1 230 CYS n 
1 231 ILE n 
1 232 MET n 
1 233 ALA n 
1 234 GLU n 
1 235 LEU n 
1 236 LEU n 
1 237 THR n 
1 238 GLY n 
1 239 ARG n 
1 240 THR n 
1 241 LEU n 
1 242 PHE n 
1 243 PRO n 
1 244 GLY n 
1 245 THR n 
1 246 ASP n 
1 247 HIS n 
1 248 ILE n 
1 249 ASP n 
1 250 GLN n 
1 251 LEU n 
1 252 LYS n 
1 253 LEU n 
1 254 ILE n 
1 255 LEU n 
1 256 ARG n 
1 257 LEU n 
1 258 VAL n 
1 259 GLY n 
1 260 THR n 
1 261 PRO n 
1 262 GLY n 
1 263 ALA n 
1 264 GLU n 
1 265 LEU n 
1 266 LEU n 
1 267 LYS n 
1 268 LYS n 
1 269 ILE n 
1 270 SER n 
1 271 SER n 
1 272 GLU n 
1 273 SER n 
1 274 ALA n 
1 275 ARG n 
1 276 ASN n 
1 277 TYR n 
1 278 ILE n 
1 279 GLN n 
1 280 SER n 
1 281 LEU n 
1 282 ALA n 
1 283 GLN n 
1 284 MET n 
1 285 PRO n 
1 286 LYS n 
1 287 MET n 
1 288 ASN n 
1 289 PHE n 
1 290 ALA n 
1 291 ASN n 
1 292 VAL n 
1 293 PHE n 
1 294 ILE n 
1 295 GLY n 
1 296 ALA n 
1 297 ASN n 
1 298 PRO n 
1 299 LEU n 
1 300 ALA n 
1 301 VAL n 
1 302 ASP n 
1 303 LEU n 
1 304 LEU n 
1 305 GLU n 
1 306 LYS n 
1 307 MET n 
1 308 LEU n 
1 309 VAL n 
1 310 LEU n 
1 311 ASP n 
1 312 SER n 
1 313 ASP n 
1 314 LYS n 
1 315 ARG n 
1 316 ILE n 
1 317 THR n 
1 318 ALA n 
1 319 ALA n 
1 320 GLN n 
1 321 ALA n 
1 322 LEU n 
1 323 ALA n 
1 324 HIS n 
1 325 ALA n 
1 326 TYR n 
1 327 PHE n 
1 328 ALA n 
1 329 GLN n 
1 330 TYR n 
1 331 HIS n 
1 332 ASP n 
1 333 PRO n 
1 334 ASP n 
1 335 ASP n 
1 336 GLU n 
1 337 PRO n 
1 338 VAL n 
1 339 ALA n 
1 340 ASP n 
1 341 PRO n 
1 342 TYR n 
1 343 ASP n 
1 344 GLN n 
1 345 SER n 
1 346 PHE n 
1 347 GLU n 
1 348 SER n 
1 349 ARG n 
1 350 ASP n 
1 351 LEU n 
1 352 LEU n 
1 353 ILE n 
1 354 ASP n 
1 355 GLU n 
1 356 TRP n 
1 357 LYS n 
1 358 SER n 
1 359 LEU n 
1 360 THR n 
1 361 TYR n 
1 362 ASP n 
1 363 GLU n 
1 364 VAL n 
1 365 ILE n 
1 366 SER n 
1 367 PHE n 
1 368 VAL n 
1 369 PRO n 
1 370 PRO n 
1 371 PRO n 
1 372 LEU n 
1 373 ASP n 
1 374 GLN n 
1 375 GLU n 
1 376 GLU n 
1 377 MET n 
1 378 GLU n 
1 379 SER n 
2 1   ARG n 
2 2   LEU n 
2 3   GLN n 
2 4   GLU n 
2 5   ARG n 
2 6   ARG n 
2 7   GLY n 
2 8   SER n 
2 9   ASN n 
2 10  VAL n 
2 11  ALA n 
2 12  LEU n 
2 13  MET n 
2 14  LEU n 
2 15  ASP n 
2 16  CYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   379 
_entity_src_gen.gene_src_common_name               'house mouse' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'Mapk14, Crk1, Csbp1, Csbp2' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Mus musculus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10090 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       16 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -18 ?   ?   ?   A . n 
A 1 2   SER 2   -17 ?   ?   ?   A . n 
A 1 3   SER 3   -16 ?   ?   ?   A . n 
A 1 4   HIS 4   -15 ?   ?   ?   A . n 
A 1 5   HIS 5   -14 ?   ?   ?   A . n 
A 1 6   HIS 6   -13 ?   ?   ?   A . n 
A 1 7   HIS 7   -12 ?   ?   ?   A . n 
A 1 8   HIS 8   -11 ?   ?   ?   A . n 
A 1 9   HIS 9   -10 ?   ?   ?   A . n 
A 1 10  SER 10  -9  ?   ?   ?   A . n 
A 1 11  SER 11  -8  ?   ?   ?   A . n 
A 1 12  GLY 12  -7  ?   ?   ?   A . n 
A 1 13  LEU 13  -6  ?   ?   ?   A . n 
A 1 14  VAL 14  -5  ?   ?   ?   A . n 
A 1 15  PRO 15  -4  ?   ?   ?   A . n 
A 1 16  ARG 16  -3  ?   ?   ?   A . n 
A 1 17  GLY 17  -2  ?   ?   ?   A . n 
A 1 18  SER 18  -1  ?   ?   ?   A . n 
A 1 19  HIS 19  0   0   HIS HIS A . n 
A 1 20  MET 20  1   1   MET MET A . n 
A 1 21  SER 21  2   2   SER SER A . n 
A 1 22  GLN 22  3   3   GLN GLN A . n 
A 1 23  GLU 23  4   4   GLU GLU A . n 
A 1 24  ARG 24  5   5   ARG ARG A . n 
A 1 25  PRO 25  6   6   PRO PRO A . n 
A 1 26  THR 26  7   7   THR THR A . n 
A 1 27  PHE 27  8   8   PHE PHE A . n 
A 1 28  TYR 28  9   9   TYR TYR A . n 
A 1 29  ARG 29  10  10  ARG ARG A . n 
A 1 30  GLN 30  11  11  GLN GLN A . n 
A 1 31  GLU 31  12  12  GLU GLU A . n 
A 1 32  LEU 32  13  13  LEU LEU A . n 
A 1 33  ASN 33  14  14  ASN ASN A . n 
A 1 34  LYS 34  15  15  LYS LYS A . n 
A 1 35  THR 35  16  16  THR THR A . n 
A 1 36  ILE 36  17  17  ILE ILE A . n 
A 1 37  TRP 37  18  18  TRP TRP A . n 
A 1 38  GLU 38  19  19  GLU GLU A . n 
A 1 39  VAL 39  20  20  VAL VAL A . n 
A 1 40  PRO 40  21  21  PRO PRO A . n 
A 1 41  GLU 41  22  22  GLU GLU A . n 
A 1 42  ARG 42  23  23  ARG ARG A . n 
A 1 43  TYR 43  24  24  TYR TYR A . n 
A 1 44  GLN 44  25  25  GLN GLN A . n 
A 1 45  ASN 45  26  26  ASN ASN A . n 
A 1 46  LEU 46  27  27  LEU LEU A . n 
A 1 47  SER 47  28  28  SER SER A . n 
A 1 48  PRO 48  29  29  PRO PRO A . n 
A 1 49  VAL 49  30  30  VAL VAL A . n 
A 1 50  GLY 50  31  31  GLY GLY A . n 
A 1 51  SER 51  32  32  SER SER A . n 
A 1 52  GLY 52  33  33  GLY GLY A . n 
A 1 53  ALA 53  34  34  ALA ALA A . n 
A 1 54  TYR 54  35  35  TYR TYR A . n 
A 1 55  GLY 55  36  36  GLY GLY A . n 
A 1 56  SER 56  37  37  SER SER A . n 
A 1 57  VAL 57  38  38  VAL VAL A . n 
A 1 58  CYS 58  39  39  CYS CYS A . n 
A 1 59  ALA 59  40  40  ALA ALA A . n 
A 1 60  ALA 60  41  41  ALA ALA A . n 
A 1 61  PHE 61  42  42  PHE PHE A . n 
A 1 62  ASP 62  43  43  ASP ASP A . n 
A 1 63  THR 63  44  44  THR THR A . n 
A 1 64  LYS 64  45  45  LYS LYS A . n 
A 1 65  THR 65  46  46  THR THR A . n 
A 1 66  GLY 66  47  47  GLY GLY A . n 
A 1 67  HIS 67  48  48  HIS HIS A . n 
A 1 68  ARG 68  49  49  ARG ARG A . n 
A 1 69  VAL 69  50  50  VAL VAL A . n 
A 1 70  ALA 70  51  51  ALA ALA A . n 
A 1 71  VAL 71  52  52  VAL VAL A . n 
A 1 72  LYS 72  53  53  LYS LYS A . n 
A 1 73  LYS 73  54  54  LYS LYS A . n 
A 1 74  LEU 74  55  55  LEU LEU A . n 
A 1 75  SER 75  56  56  SER SER A . n 
A 1 76  ARG 76  57  57  ARG ARG A . n 
A 1 77  PRO 77  58  58  PRO PRO A . n 
A 1 78  PHE 78  59  59  PHE PHE A . n 
A 1 79  GLN 79  60  60  GLN GLN A . n 
A 1 80  SER 80  61  61  SER SER A . n 
A 1 81  ILE 81  62  62  ILE ILE A . n 
A 1 82  ILE 82  63  63  ILE ILE A . n 
A 1 83  HIS 83  64  64  HIS HIS A . n 
A 1 84  ALA 84  65  65  ALA ALA A . n 
A 1 85  LYS 85  66  66  LYS LYS A . n 
A 1 86  ARG 86  67  67  ARG ARG A . n 
A 1 87  THR 87  68  68  THR THR A . n 
A 1 88  TYR 88  69  69  TYR TYR A . n 
A 1 89  ARG 89  70  70  ARG ARG A . n 
A 1 90  GLU 90  71  71  GLU GLU A . n 
A 1 91  LEU 91  72  72  LEU LEU A . n 
A 1 92  ARG 92  73  73  ARG ARG A . n 
A 1 93  LEU 93  74  74  LEU LEU A . n 
A 1 94  LEU 94  75  75  LEU LEU A . n 
A 1 95  LYS 95  76  76  LYS LYS A . n 
A 1 96  HIS 96  77  77  HIS HIS A . n 
A 1 97  MET 97  78  78  MET MET A . n 
A 1 98  LYS 98  79  79  LYS LYS A . n 
A 1 99  HIS 99  80  80  HIS HIS A . n 
A 1 100 GLU 100 81  81  GLU GLU A . n 
A 1 101 ASN 101 82  82  ASN ASN A . n 
A 1 102 VAL 102 83  83  VAL VAL A . n 
A 1 103 ILE 103 84  84  ILE ILE A . n 
A 1 104 GLY 104 85  85  GLY GLY A . n 
A 1 105 LEU 105 86  86  LEU LEU A . n 
A 1 106 LEU 106 87  87  LEU LEU A . n 
A 1 107 ASP 107 88  88  ASP ASP A . n 
A 1 108 VAL 108 89  89  VAL VAL A . n 
A 1 109 PHE 109 90  90  PHE PHE A . n 
A 1 110 THR 110 91  91  THR THR A . n 
A 1 111 PRO 111 92  92  PRO PRO A . n 
A 1 112 ALA 112 93  93  ALA ALA A . n 
A 1 113 ARG 113 94  94  ARG ARG A . n 
A 1 114 SER 114 95  95  SER SER A . n 
A 1 115 LEU 115 96  96  LEU LEU A . n 
A 1 116 GLU 116 97  97  GLU GLU A . n 
A 1 117 GLU 117 98  98  GLU GLU A . n 
A 1 118 PHE 118 99  99  PHE PHE A . n 
A 1 119 ASN 119 100 100 ASN ASN A . n 
A 1 120 ASP 120 101 101 ASP ASP A . n 
A 1 121 VAL 121 102 102 VAL VAL A . n 
A 1 122 TYR 122 103 103 TYR TYR A . n 
A 1 123 LEU 123 104 104 LEU LEU A . n 
A 1 124 VAL 124 105 105 VAL VAL A . n 
A 1 125 THR 125 106 106 THR THR A . n 
A 1 126 HIS 126 107 107 HIS HIS A . n 
A 1 127 LEU 127 108 108 LEU LEU A . n 
A 1 128 MET 128 109 109 MET MET A . n 
A 1 129 GLY 129 110 110 GLY GLY A . n 
A 1 130 ALA 130 111 111 ALA ALA A . n 
A 1 131 ASP 131 112 112 ASP ASP A . n 
A 1 132 LEU 132 113 113 LEU LEU A . n 
A 1 133 ASN 133 114 114 ASN ASN A . n 
A 1 134 ASN 134 115 115 ASN ASN A . n 
A 1 135 ILE 135 116 116 ILE ILE A . n 
A 1 136 VAL 136 117 117 VAL VAL A . n 
A 1 137 LYS 137 118 118 LYS LYS A . n 
A 1 138 CYS 138 119 119 CYS CYS A . n 
A 1 139 GLN 139 120 120 GLN GLN A . n 
A 1 140 LYS 140 121 121 LYS LYS A . n 
A 1 141 LEU 141 122 122 LEU LEU A . n 
A 1 142 THR 142 123 123 THR THR A . n 
A 1 143 ASP 143 124 124 ASP ASP A . n 
A 1 144 ASP 144 125 125 ASP ASP A . n 
A 1 145 HIS 145 126 126 HIS HIS A . n 
A 1 146 VAL 146 127 127 VAL VAL A . n 
A 1 147 GLN 147 128 128 GLN GLN A . n 
A 1 148 PHE 148 129 129 PHE PHE A . n 
A 1 149 LEU 149 130 130 LEU LEU A . n 
A 1 150 ILE 150 131 131 ILE ILE A . n 
A 1 151 TYR 151 132 132 TYR TYR A . n 
A 1 152 GLN 152 133 133 GLN GLN A . n 
A 1 153 ILE 153 134 134 ILE ILE A . n 
A 1 154 LEU 154 135 135 LEU LEU A . n 
A 1 155 ARG 155 136 136 ARG ARG A . n 
A 1 156 GLY 156 137 137 GLY GLY A . n 
A 1 157 LEU 157 138 138 LEU LEU A . n 
A 1 158 LYS 158 139 139 LYS LYS A . n 
A 1 159 TYR 159 140 140 TYR TYR A . n 
A 1 160 ILE 160 141 141 ILE ILE A . n 
A 1 161 HIS 161 142 142 HIS HIS A . n 
A 1 162 SER 162 143 143 SER SER A . n 
A 1 163 ALA 163 144 144 ALA ALA A . n 
A 1 164 ASP 164 145 145 ASP ASP A . n 
A 1 165 ILE 165 146 146 ILE ILE A . n 
A 1 166 ILE 166 147 147 ILE ILE A . n 
A 1 167 HIS 167 148 148 HIS HIS A . n 
A 1 168 ARG 168 149 149 ARG ARG A . n 
A 1 169 ASP 169 150 150 ASP ASP A . n 
A 1 170 LEU 170 151 151 LEU LEU A . n 
A 1 171 LYS 171 152 152 LYS LYS A . n 
A 1 172 PRO 172 153 153 PRO PRO A . n 
A 1 173 SER 173 154 154 SER SER A . n 
A 1 174 ASN 174 155 155 ASN ASN A . n 
A 1 175 LEU 175 156 156 LEU LEU A . n 
A 1 176 ALA 176 157 157 ALA ALA A . n 
A 1 177 VAL 177 158 158 VAL VAL A . n 
A 1 178 ASN 178 159 159 ASN ASN A . n 
A 1 179 GLU 179 160 160 GLU GLU A . n 
A 1 180 ASP 180 161 161 ASP ASP A . n 
A 1 181 CYS 181 162 162 CYS CYS A . n 
A 1 182 GLU 182 163 163 GLU GLU A . n 
A 1 183 LEU 183 164 164 LEU LEU A . n 
A 1 184 LYS 184 165 165 LYS LYS A . n 
A 1 185 ILE 185 166 166 ILE ILE A . n 
A 1 186 LEU 186 167 167 LEU LEU A . n 
A 1 187 ASP 187 168 168 ASP ASP A . n 
A 1 188 PHE 188 169 169 PHE PHE A . n 
A 1 189 GLY 189 170 170 GLY GLY A . n 
A 1 190 LEU 190 171 171 LEU LEU A . n 
A 1 191 ALA 191 172 172 ALA ALA A . n 
A 1 192 ARG 192 173 173 ARG ARG A . n 
A 1 193 HIS 193 174 ?   ?   ?   A . n 
A 1 194 THR 194 175 ?   ?   ?   A . n 
A 1 195 ASP 195 176 ?   ?   ?   A . n 
A 1 196 ASP 196 177 ?   ?   ?   A . n 
A 1 197 GLU 197 178 ?   ?   ?   A . n 
A 1 198 MET 198 179 ?   ?   ?   A . n 
A 1 199 THR 199 180 ?   ?   ?   A . n 
A 1 200 GLY 200 181 ?   ?   ?   A . n 
A 1 201 TYR 201 182 ?   ?   ?   A . n 
A 1 202 VAL 202 183 ?   ?   ?   A . n 
A 1 203 ALA 203 184 ?   ?   ?   A . n 
A 1 204 THR 204 185 185 THR THR A . n 
A 1 205 ARG 205 186 186 ARG ARG A . n 
A 1 206 TRP 206 187 187 TRP TRP A . n 
A 1 207 TYR 207 188 188 TYR TYR A . n 
A 1 208 ARG 208 189 189 ARG ARG A . n 
A 1 209 ALA 209 190 190 ALA ALA A . n 
A 1 210 PRO 210 191 191 PRO PRO A . n 
A 1 211 GLU 211 192 192 GLU GLU A . n 
A 1 212 ILE 212 193 193 ILE ILE A . n 
A 1 213 MET 213 194 194 MET MET A . n 
A 1 214 LEU 214 195 195 LEU LEU A . n 
A 1 215 ASN 215 196 196 ASN ASN A . n 
A 1 216 TRP 216 197 197 TRP TRP A . n 
A 1 217 MET 217 198 198 MET MET A . n 
A 1 218 HIS 218 199 199 HIS HIS A . n 
A 1 219 TYR 219 200 200 TYR TYR A . n 
A 1 220 ASN 220 201 201 ASN ASN A . n 
A 1 221 GLN 221 202 202 GLN GLN A . n 
A 1 222 THR 222 203 203 THR THR A . n 
A 1 223 VAL 223 204 204 VAL VAL A . n 
A 1 224 ASP 224 205 205 ASP ASP A . n 
A 1 225 ILE 225 206 206 ILE ILE A . n 
A 1 226 TRP 226 207 207 TRP TRP A . n 
A 1 227 SER 227 208 208 SER SER A . n 
A 1 228 VAL 228 209 209 VAL VAL A . n 
A 1 229 GLY 229 210 210 GLY GLY A . n 
A 1 230 CYS 230 211 211 CYS CYS A . n 
A 1 231 ILE 231 212 212 ILE ILE A . n 
A 1 232 MET 232 213 213 MET MET A . n 
A 1 233 ALA 233 214 214 ALA ALA A . n 
A 1 234 GLU 234 215 215 GLU GLU A . n 
A 1 235 LEU 235 216 216 LEU LEU A . n 
A 1 236 LEU 236 217 217 LEU LEU A . n 
A 1 237 THR 237 218 218 THR THR A . n 
A 1 238 GLY 238 219 219 GLY GLY A . n 
A 1 239 ARG 239 220 220 ARG ARG A . n 
A 1 240 THR 240 221 221 THR THR A . n 
A 1 241 LEU 241 222 222 LEU LEU A . n 
A 1 242 PHE 242 223 223 PHE PHE A . n 
A 1 243 PRO 243 224 224 PRO PRO A . n 
A 1 244 GLY 244 225 225 GLY GLY A . n 
A 1 245 THR 245 226 226 THR THR A . n 
A 1 246 ASP 246 227 227 ASP ASP A . n 
A 1 247 HIS 247 228 228 HIS HIS A . n 
A 1 248 ILE 248 229 229 ILE ILE A . n 
A 1 249 ASP 249 230 230 ASP ASP A . n 
A 1 250 GLN 250 231 231 GLN GLN A . n 
A 1 251 LEU 251 232 232 LEU LEU A . n 
A 1 252 LYS 252 233 233 LYS LYS A . n 
A 1 253 LEU 253 234 234 LEU LEU A . n 
A 1 254 ILE 254 235 235 ILE ILE A . n 
A 1 255 LEU 255 236 236 LEU LEU A . n 
A 1 256 ARG 256 237 237 ARG ARG A . n 
A 1 257 LEU 257 238 238 LEU LEU A . n 
A 1 258 VAL 258 239 239 VAL VAL A . n 
A 1 259 GLY 259 240 240 GLY GLY A . n 
A 1 260 THR 260 241 241 THR THR A . n 
A 1 261 PRO 261 242 242 PRO PRO A . n 
A 1 262 GLY 262 243 243 GLY GLY A . n 
A 1 263 ALA 263 244 244 ALA ALA A . n 
A 1 264 GLU 264 245 245 GLU GLU A . n 
A 1 265 LEU 265 246 246 LEU LEU A . n 
A 1 266 LEU 266 247 247 LEU LEU A . n 
A 1 267 LYS 267 248 248 LYS LYS A . n 
A 1 268 LYS 268 249 249 LYS LYS A . n 
A 1 269 ILE 269 250 250 ILE ILE A . n 
A 1 270 SER 270 251 251 SER SER A . n 
A 1 271 SER 271 252 252 SER SER A . n 
A 1 272 GLU 272 253 253 GLU GLU A . n 
A 1 273 SER 273 254 254 SER SER A . n 
A 1 274 ALA 274 255 255 ALA ALA A . n 
A 1 275 ARG 275 256 256 ARG ARG A . n 
A 1 276 ASN 276 257 257 ASN ASN A . n 
A 1 277 TYR 277 258 258 TYR TYR A . n 
A 1 278 ILE 278 259 259 ILE ILE A . n 
A 1 279 GLN 279 260 260 GLN GLN A . n 
A 1 280 SER 280 261 261 SER SER A . n 
A 1 281 LEU 281 262 262 LEU LEU A . n 
A 1 282 ALA 282 263 263 ALA ALA A . n 
A 1 283 GLN 283 264 264 GLN GLN A . n 
A 1 284 MET 284 265 265 MET MET A . n 
A 1 285 PRO 285 266 266 PRO PRO A . n 
A 1 286 LYS 286 267 267 LYS LYS A . n 
A 1 287 MET 287 268 268 MET MET A . n 
A 1 288 ASN 288 269 269 ASN ASN A . n 
A 1 289 PHE 289 270 270 PHE PHE A . n 
A 1 290 ALA 290 271 271 ALA ALA A . n 
A 1 291 ASN 291 272 272 ASN ASN A . n 
A 1 292 VAL 292 273 273 VAL VAL A . n 
A 1 293 PHE 293 274 274 PHE PHE A . n 
A 1 294 ILE 294 275 275 ILE ILE A . n 
A 1 295 GLY 295 276 276 GLY GLY A . n 
A 1 296 ALA 296 277 277 ALA ALA A . n 
A 1 297 ASN 297 278 278 ASN ASN A . n 
A 1 298 PRO 298 279 279 PRO PRO A . n 
A 1 299 LEU 299 280 280 LEU LEU A . n 
A 1 300 ALA 300 281 281 ALA ALA A . n 
A 1 301 VAL 301 282 282 VAL VAL A . n 
A 1 302 ASP 302 283 283 ASP ASP A . n 
A 1 303 LEU 303 284 284 LEU LEU A . n 
A 1 304 LEU 304 285 285 LEU LEU A . n 
A 1 305 GLU 305 286 286 GLU GLU A . n 
A 1 306 LYS 306 287 287 LYS LYS A . n 
A 1 307 MET 307 288 288 MET MET A . n 
A 1 308 LEU 308 289 289 LEU LEU A . n 
A 1 309 VAL 309 290 290 VAL VAL A . n 
A 1 310 LEU 310 291 291 LEU LEU A . n 
A 1 311 ASP 311 292 292 ASP ASP A . n 
A 1 312 SER 312 293 293 SER SER A . n 
A 1 313 ASP 313 294 294 ASP ASP A . n 
A 1 314 LYS 314 295 295 LYS LYS A . n 
A 1 315 ARG 315 296 296 ARG ARG A . n 
A 1 316 ILE 316 297 297 ILE ILE A . n 
A 1 317 THR 317 298 298 THR THR A . n 
A 1 318 ALA 318 299 299 ALA ALA A . n 
A 1 319 ALA 319 300 300 ALA ALA A . n 
A 1 320 GLN 320 301 301 GLN GLN A . n 
A 1 321 ALA 321 302 302 ALA ALA A . n 
A 1 322 LEU 322 303 303 LEU LEU A . n 
A 1 323 ALA 323 304 304 ALA ALA A . n 
A 1 324 HIS 324 305 305 HIS HIS A . n 
A 1 325 ALA 325 306 306 ALA ALA A . n 
A 1 326 TYR 326 307 307 TYR TYR A . n 
A 1 327 PHE 327 308 308 PHE PHE A . n 
A 1 328 ALA 328 309 309 ALA ALA A . n 
A 1 329 GLN 329 310 310 GLN GLN A . n 
A 1 330 TYR 330 311 311 TYR TYR A . n 
A 1 331 HIS 331 312 312 HIS HIS A . n 
A 1 332 ASP 332 313 313 ASP ASP A . n 
A 1 333 PRO 333 314 314 PRO PRO A . n 
A 1 334 ASP 334 315 315 ASP ASP A . n 
A 1 335 ASP 335 316 316 ASP ASP A . n 
A 1 336 GLU 336 317 317 GLU GLU A . n 
A 1 337 PRO 337 318 318 PRO PRO A . n 
A 1 338 VAL 338 319 319 VAL VAL A . n 
A 1 339 ALA 339 320 320 ALA ALA A . n 
A 1 340 ASP 340 321 321 ASP ASP A . n 
A 1 341 PRO 341 322 322 PRO PRO A . n 
A 1 342 TYR 342 323 323 TYR TYR A . n 
A 1 343 ASP 343 324 324 ASP ASP A . n 
A 1 344 GLN 344 325 325 GLN GLN A . n 
A 1 345 SER 345 326 326 SER SER A . n 
A 1 346 PHE 346 327 327 PHE PHE A . n 
A 1 347 GLU 347 328 328 GLU GLU A . n 
A 1 348 SER 348 329 329 SER SER A . n 
A 1 349 ARG 349 330 330 ARG ARG A . n 
A 1 350 ASP 350 331 331 ASP ASP A . n 
A 1 351 LEU 351 332 332 LEU LEU A . n 
A 1 352 LEU 352 333 333 LEU LEU A . n 
A 1 353 ILE 353 334 334 ILE ILE A . n 
A 1 354 ASP 354 335 335 ASP ASP A . n 
A 1 355 GLU 355 336 336 GLU GLU A . n 
A 1 356 TRP 356 337 337 TRP TRP A . n 
A 1 357 LYS 357 338 338 LYS LYS A . n 
A 1 358 SER 358 339 339 SER SER A . n 
A 1 359 LEU 359 340 340 LEU LEU A . n 
A 1 360 THR 360 341 341 THR THR A . n 
A 1 361 TYR 361 342 342 TYR TYR A . n 
A 1 362 ASP 362 343 343 ASP ASP A . n 
A 1 363 GLU 363 344 344 GLU GLU A . n 
A 1 364 VAL 364 345 345 VAL VAL A . n 
A 1 365 ILE 365 346 346 ILE ILE A . n 
A 1 366 SER 366 347 347 SER SER A . n 
A 1 367 PHE 367 348 348 PHE PHE A . n 
A 1 368 VAL 368 349 349 VAL VAL A . n 
A 1 369 PRO 369 350 350 PRO PRO A . n 
A 1 370 PRO 370 351 351 PRO PRO A . n 
A 1 371 PRO 371 352 352 PRO PRO A . n 
A 1 372 LEU 372 353 353 LEU LEU A . n 
A 1 373 ASP 373 354 ?   ?   ?   A . n 
A 1 374 GLN 374 355 ?   ?   ?   A . n 
A 1 375 GLU 375 356 ?   ?   ?   A . n 
A 1 376 GLU 376 357 ?   ?   ?   A . n 
A 1 377 MET 377 358 ?   ?   ?   A . n 
A 1 378 GLU 378 359 ?   ?   ?   A . n 
A 1 379 SER 379 360 ?   ?   ?   A . n 
B 2 1   ARG 1   16  16  ARG ARG B . n 
B 2 2   LEU 2   17  17  LEU LEU B . n 
B 2 3   GLN 3   18  18  GLN GLN B . n 
B 2 4   GLU 4   19  19  GLU GLU B . n 
B 2 5   ARG 5   20  20  ARG ARG B . n 
B 2 6   ARG 6   21  21  ARG ARG B . n 
B 2 7   GLY 7   22  22  GLY GLY B . n 
B 2 8   SER 8   23  23  SER SER B . n 
B 2 9   ASN 9   24  24  ASN ASN B . n 
B 2 10  VAL 10  25  25  VAL VAL B . n 
B 2 11  ALA 11  26  26  ALA ALA B . n 
B 2 12  LEU 12  27  27  LEU LEU B . n 
B 2 13  MET 13  28  28  MET MET B . n 
B 2 14  LEU 14  29  29  LEU LEU B . n 
B 2 15  ASP 15  30  30  ASP ASP B . n 
B 2 16  CYS 16  31  31  CYS CYS B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   401 401 HOH HOH A . 
C 3 HOH 2   402 402 HOH HOH A . 
C 3 HOH 3   403 403 HOH HOH A . 
C 3 HOH 4   404 404 HOH HOH A . 
C 3 HOH 5   405 405 HOH HOH A . 
C 3 HOH 6   406 406 HOH HOH A . 
C 3 HOH 7   407 407 HOH HOH A . 
C 3 HOH 8   408 408 HOH HOH A . 
C 3 HOH 9   409 409 HOH HOH A . 
C 3 HOH 10  410 410 HOH HOH A . 
C 3 HOH 11  411 411 HOH HOH A . 
C 3 HOH 12  412 412 HOH HOH A . 
C 3 HOH 13  413 413 HOH HOH A . 
C 3 HOH 14  414 414 HOH HOH A . 
C 3 HOH 15  415 415 HOH HOH A . 
C 3 HOH 16  416 416 HOH HOH A . 
C 3 HOH 17  417 417 HOH HOH A . 
C 3 HOH 18  418 418 HOH HOH A . 
C 3 HOH 19  419 419 HOH HOH A . 
C 3 HOH 20  420 420 HOH HOH A . 
C 3 HOH 21  421 421 HOH HOH A . 
C 3 HOH 22  422 422 HOH HOH A . 
C 3 HOH 23  423 423 HOH HOH A . 
C 3 HOH 24  424 424 HOH HOH A . 
C 3 HOH 25  425 425 HOH HOH A . 
C 3 HOH 26  426 426 HOH HOH A . 
C 3 HOH 27  427 427 HOH HOH A . 
C 3 HOH 28  428 428 HOH HOH A . 
C 3 HOH 29  429 429 HOH HOH A . 
C 3 HOH 30  430 430 HOH HOH A . 
C 3 HOH 31  431 431 HOH HOH A . 
C 3 HOH 32  432 432 HOH HOH A . 
C 3 HOH 33  433 433 HOH HOH A . 
C 3 HOH 34  434 434 HOH HOH A . 
C 3 HOH 35  435 435 HOH HOH A . 
C 3 HOH 36  436 436 HOH HOH A . 
C 3 HOH 37  437 437 HOH HOH A . 
C 3 HOH 38  438 438 HOH HOH A . 
C 3 HOH 39  439 439 HOH HOH A . 
C 3 HOH 40  440 440 HOH HOH A . 
C 3 HOH 41  441 441 HOH HOH A . 
C 3 HOH 42  442 442 HOH HOH A . 
C 3 HOH 43  443 443 HOH HOH A . 
C 3 HOH 44  444 444 HOH HOH A . 
C 3 HOH 45  445 445 HOH HOH A . 
C 3 HOH 46  446 446 HOH HOH A . 
C 3 HOH 47  447 447 HOH HOH A . 
C 3 HOH 48  448 448 HOH HOH A . 
C 3 HOH 49  449 449 HOH HOH A . 
C 3 HOH 50  450 450 HOH HOH A . 
C 3 HOH 51  451 451 HOH HOH A . 
C 3 HOH 52  452 452 HOH HOH A . 
C 3 HOH 53  453 453 HOH HOH A . 
C 3 HOH 54  454 454 HOH HOH A . 
C 3 HOH 55  455 455 HOH HOH A . 
C 3 HOH 56  456 456 HOH HOH A . 
C 3 HOH 57  457 457 HOH HOH A . 
C 3 HOH 58  458 458 HOH HOH A . 
C 3 HOH 59  459 459 HOH HOH A . 
C 3 HOH 60  460 460 HOH HOH A . 
C 3 HOH 61  461 461 HOH HOH A . 
C 3 HOH 62  462 462 HOH HOH A . 
C 3 HOH 63  463 463 HOH HOH A . 
C 3 HOH 64  464 464 HOH HOH A . 
C 3 HOH 65  465 465 HOH HOH A . 
C 3 HOH 66  466 466 HOH HOH A . 
C 3 HOH 67  467 467 HOH HOH A . 
C 3 HOH 68  468 468 HOH HOH A . 
C 3 HOH 69  469 469 HOH HOH A . 
C 3 HOH 70  470 470 HOH HOH A . 
C 3 HOH 71  471 471 HOH HOH A . 
C 3 HOH 72  472 472 HOH HOH A . 
C 3 HOH 73  473 473 HOH HOH A . 
C 3 HOH 74  474 474 HOH HOH A . 
C 3 HOH 75  475 475 HOH HOH A . 
C 3 HOH 76  476 476 HOH HOH A . 
C 3 HOH 77  477 477 HOH HOH A . 
C 3 HOH 78  478 478 HOH HOH A . 
C 3 HOH 79  479 479 HOH HOH A . 
C 3 HOH 80  480 480 HOH HOH A . 
C 3 HOH 81  481 481 HOH HOH A . 
C 3 HOH 82  482 482 HOH HOH A . 
C 3 HOH 83  483 483 HOH HOH A . 
C 3 HOH 84  484 484 HOH HOH A . 
C 3 HOH 85  485 485 HOH HOH A . 
C 3 HOH 86  486 486 HOH HOH A . 
C 3 HOH 87  487 487 HOH HOH A . 
C 3 HOH 88  488 488 HOH HOH A . 
C 3 HOH 89  489 489 HOH HOH A . 
C 3 HOH 90  490 490 HOH HOH A . 
C 3 HOH 91  491 491 HOH HOH A . 
C 3 HOH 92  492 492 HOH HOH A . 
C 3 HOH 93  493 493 HOH HOH A . 
C 3 HOH 94  494 494 HOH HOH A . 
C 3 HOH 95  495 495 HOH HOH A . 
C 3 HOH 96  496 496 HOH HOH A . 
C 3 HOH 97  497 497 HOH HOH A . 
C 3 HOH 98  498 498 HOH HOH A . 
C 3 HOH 99  499 499 HOH HOH A . 
C 3 HOH 100 500 500 HOH HOH A . 
C 3 HOH 101 501 501 HOH HOH A . 
C 3 HOH 102 502 502 HOH HOH A . 
C 3 HOH 103 503 503 HOH HOH A . 
C 3 HOH 104 504 504 HOH HOH A . 
C 3 HOH 105 505 505 HOH HOH A . 
C 3 HOH 106 506 506 HOH HOH A . 
C 3 HOH 107 507 507 HOH HOH A . 
C 3 HOH 108 508 508 HOH HOH A . 
C 3 HOH 109 509 509 HOH HOH A . 
C 3 HOH 110 510 510 HOH HOH A . 
C 3 HOH 111 511 511 HOH HOH A . 
C 3 HOH 112 512 512 HOH HOH A . 
C 3 HOH 113 513 513 HOH HOH A . 
C 3 HOH 114 514 514 HOH HOH A . 
C 3 HOH 115 515 515 HOH HOH A . 
C 3 HOH 116 516 516 HOH HOH A . 
C 3 HOH 117 517 517 HOH HOH A . 
C 3 HOH 118 518 518 HOH HOH A . 
C 3 HOH 119 519 519 HOH HOH A . 
C 3 HOH 120 520 520 HOH HOH A . 
C 3 HOH 121 521 521 HOH HOH A . 
C 3 HOH 122 522 522 HOH HOH A . 
C 3 HOH 123 523 523 HOH HOH A . 
C 3 HOH 124 524 524 HOH HOH A . 
C 3 HOH 125 525 525 HOH HOH A . 
C 3 HOH 126 526 526 HOH HOH A . 
C 3 HOH 127 527 527 HOH HOH A . 
C 3 HOH 128 528 528 HOH HOH A . 
C 3 HOH 129 529 529 HOH HOH A . 
C 3 HOH 130 530 530 HOH HOH A . 
C 3 HOH 131 531 531 HOH HOH A . 
C 3 HOH 132 532 532 HOH HOH A . 
C 3 HOH 133 533 533 HOH HOH A . 
C 3 HOH 134 534 534 HOH HOH A . 
C 3 HOH 135 535 535 HOH HOH A . 
C 3 HOH 136 536 536 HOH HOH A . 
C 3 HOH 137 537 537 HOH HOH A . 
C 3 HOH 138 538 538 HOH HOH A . 
C 3 HOH 139 539 539 HOH HOH A . 
C 3 HOH 140 540 540 HOH HOH A . 
C 3 HOH 141 541 541 HOH HOH A . 
C 3 HOH 142 542 542 HOH HOH A . 
C 3 HOH 143 543 543 HOH HOH A . 
C 3 HOH 144 544 544 HOH HOH A . 
C 3 HOH 145 545 545 HOH HOH A . 
C 3 HOH 146 546 546 HOH HOH A . 
C 3 HOH 147 547 547 HOH HOH A . 
C 3 HOH 148 548 548 HOH HOH A . 
C 3 HOH 149 549 549 HOH HOH A . 
C 3 HOH 150 550 550 HOH HOH A . 
C 3 HOH 151 551 551 HOH HOH A . 
C 3 HOH 152 552 552 HOH HOH A . 
C 3 HOH 153 553 553 HOH HOH A . 
C 3 HOH 154 554 554 HOH HOH A . 
C 3 HOH 155 555 555 HOH HOH A . 
C 3 HOH 156 556 556 HOH HOH A . 
C 3 HOH 157 557 557 HOH HOH A . 
C 3 HOH 158 558 558 HOH HOH A . 
C 3 HOH 159 559 559 HOH HOH A . 
C 3 HOH 160 560 560 HOH HOH A . 
C 3 HOH 161 561 561 HOH HOH A . 
C 3 HOH 162 562 562 HOH HOH A . 
C 3 HOH 163 563 563 HOH HOH A . 
C 3 HOH 164 564 564 HOH HOH A . 
C 3 HOH 165 565 565 HOH HOH A . 
C 3 HOH 166 566 566 HOH HOH A . 
C 3 HOH 167 567 567 HOH HOH A . 
C 3 HOH 168 568 568 HOH HOH A . 
C 3 HOH 169 569 569 HOH HOH A . 
C 3 HOH 170 570 570 HOH HOH A . 
C 3 HOH 171 571 571 HOH HOH A . 
C 3 HOH 172 572 572 HOH HOH A . 
C 3 HOH 173 573 573 HOH HOH A . 
C 3 HOH 174 574 574 HOH HOH A . 
C 3 HOH 175 575 575 HOH HOH A . 
C 3 HOH 176 576 576 HOH HOH A . 
C 3 HOH 177 577 577 HOH HOH A . 
C 3 HOH 178 578 578 HOH HOH A . 
C 3 HOH 179 579 579 HOH HOH A . 
C 3 HOH 180 580 580 HOH HOH A . 
C 3 HOH 181 581 581 HOH HOH A . 
C 3 HOH 182 582 582 HOH HOH A . 
C 3 HOH 183 583 583 HOH HOH A . 
C 3 HOH 184 584 584 HOH HOH A . 
C 3 HOH 185 585 585 HOH HOH A . 
C 3 HOH 186 586 586 HOH HOH A . 
C 3 HOH 187 587 587 HOH HOH A . 
C 3 HOH 188 588 588 HOH HOH A . 
C 3 HOH 189 589 589 HOH HOH A . 
C 3 HOH 190 590 590 HOH HOH A . 
C 3 HOH 191 591 591 HOH HOH A . 
C 3 HOH 192 592 592 HOH HOH A . 
C 3 HOH 193 593 593 HOH HOH A . 
C 3 HOH 194 594 594 HOH HOH A . 
C 3 HOH 195 595 595 HOH HOH A . 
C 3 HOH 196 596 596 HOH HOH A . 
C 3 HOH 197 597 597 HOH HOH A . 
C 3 HOH 198 598 598 HOH HOH A . 
C 3 HOH 199 599 599 HOH HOH A . 
C 3 HOH 200 600 600 HOH HOH A . 
C 3 HOH 201 601 601 HOH HOH A . 
C 3 HOH 202 602 602 HOH HOH A . 
C 3 HOH 203 603 603 HOH HOH A . 
C 3 HOH 204 604 604 HOH HOH A . 
C 3 HOH 205 605 605 HOH HOH A . 
C 3 HOH 206 606 606 HOH HOH A . 
C 3 HOH 207 607 607 HOH HOH A . 
C 3 HOH 208 608 608 HOH HOH A . 
C 3 HOH 209 609 609 HOH HOH A . 
C 3 HOH 210 610 610 HOH HOH A . 
C 3 HOH 211 611 611 HOH HOH A . 
D 3 HOH 1   201 201 HOH HOH B . 
D 3 HOH 2   202 202 HOH HOH B . 
D 3 HOH 3   203 203 HOH HOH B . 
D 3 HOH 4   204 204 HOH HOH B . 
D 3 HOH 5   205 205 HOH HOH B . 
D 3 HOH 6   206 206 HOH HOH B . 
D 3 HOH 7   207 207 HOH HOH B . 
D 3 HOH 8   208 208 HOH HOH B . 
D 3 HOH 9   209 209 HOH HOH B . 
D 3 HOH 10  210 210 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.8.0267 1 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.22     2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .        3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? XSCALE      ? ? ? .        4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .        5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YP8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     81.960 
_cell.length_a_esd                 ? 
_cell.length_b                     81.960 
_cell.length_b_esd                 ? 
_cell.length_c                     122.400 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YP8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YP8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.74 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.08 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.8 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M HEPES pH 7.8
0.6-0.8 M Sodium Citrate
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     'IMAGE PLATE' 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU RAXIS IV' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2009-04-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.542 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU R-AXIS IV' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.542 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YP8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.14 
_reflns.d_resolution_low                               46.35 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26386 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.047 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.127 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.14 
_reflns_shell.d_res_low                                     2.20 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1741 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.3 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.552 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.482 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          80.5 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.894 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.3400 
_refine.aniso_B[1][2]                            -0.1700 
_refine.aniso_B[1][3]                            -0.0000 
_refine.aniso_B[2][2]                            -0.3400 
_refine.aniso_B[2][3]                            -0.0000 
_refine.aniso_B[3][3]                            1.1000 
_refine.B_iso_max                                140.460 
_refine.B_iso_mean                               37.5600 
_refine.B_iso_min                                18.050 
_refine.correlation_coeff_Fo_to_Fc               0.9580 
_refine.correlation_coeff_Fo_to_Fc_free          0.9470 
_refine.details                                  
'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES      : REFINED INDIVIDUALLY' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YP8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.1400 
_refine.ls_d_res_low                             46.3500 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25056 
_refine.ls_number_reflns_R_free                  1290 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.9600 
_refine.ls_percent_reflns_R_free                 4.9000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1876 
_refine.ls_R_factor_R_free                       0.2161 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1862 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      1p38 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.2030 
_refine.pdbx_overall_ESU_R_Free                  0.1670 
_refine.pdbx_solvent_vdw_probe_radii             1.2000 
_refine.pdbx_solvent_ion_probe_radii             0.8000 
_refine.pdbx_solvent_shrinkage_radii             0.8000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             4.6540 
_refine.overall_SU_ML                            0.1140 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.1400 
_refine_hist.d_res_low                        46.3500 
_refine_hist.number_atoms_solvent             221 
_refine_hist.number_atoms_total               3122 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       359 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          38.29 
_refine_hist.pdbx_number_atoms_protein        2901 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.013  2966 ? r_bond_refined_d       ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.015  2841 ? r_bond_other_d         ? ? 
'X-RAY DIFFRACTION' ? 1.476  1.640  4020 ? r_angle_refined_deg    ? ? 
'X-RAY DIFFRACTION' ? 1.349  1.580  6532 ? r_angle_other_deg      ? ? 
'X-RAY DIFFRACTION' ? 6.831  5.000  356  ? r_dihedral_angle_1_deg ? ? 
'X-RAY DIFFRACTION' ? 29.730 21.890 164  ? r_dihedral_angle_2_deg ? ? 
'X-RAY DIFFRACTION' ? 11.441 15.000 524  ? r_dihedral_angle_3_deg ? ? 
'X-RAY DIFFRACTION' ? 16.000 15.000 22   ? r_dihedral_angle_4_deg ? ? 
'X-RAY DIFFRACTION' ? 0.063  0.200  382  ? r_chiral_restr         ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  3318 ? r_gen_planes_refined   ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  686  ? r_gen_planes_other     ? ? 
'X-RAY DIFFRACTION' ? 3.582  3.737  1433 ? r_mcbond_it            ? ? 
'X-RAY DIFFRACTION' ? 3.583  3.737  1432 ? r_mcbond_other         ? ? 
'X-RAY DIFFRACTION' ? 5.452  5.581  1786 ? r_mcangle_it           ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.14 
_refine_ls_shell.d_res_low                        2.1940 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             80 
_refine_ls_shell.number_reflns_R_work             1470 
_refine_ls_shell.percent_reflns_obs               78.9200 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.3260 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.3570 
# 
_struct.entry_id                     8YP8 
_struct.title                        'Structure of the p38alpha-pepHePTPm(16-31)(V31C ) complex' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YP8 
_struct_keywords.text            'MAP KINASE P38 ALPHA, docking interactions, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP MK14_MOUSE P47811 ? 1 
;MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH
ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA
DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
1  
2 UNP PTN7_HUMAN P35236 ? 2 RLQERRGSNVALMLDV 37 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YP8 A 20 ? 379 ? P47811 1  ? 360 ? 1  360 
2 2 8YP8 B 1  ? 16  ? P35236 37 ? 52  ? 16 31  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YP8 GLY A 1  ? UNP P47811 ?   ?  'expression tag'      -18 1  
1 8YP8 SER A 2  ? UNP P47811 ?   ?  'expression tag'      -17 2  
1 8YP8 SER A 3  ? UNP P47811 ?   ?  'expression tag'      -16 3  
1 8YP8 HIS A 4  ? UNP P47811 ?   ?  'expression tag'      -15 4  
1 8YP8 HIS A 5  ? UNP P47811 ?   ?  'expression tag'      -14 5  
1 8YP8 HIS A 6  ? UNP P47811 ?   ?  'expression tag'      -13 6  
1 8YP8 HIS A 7  ? UNP P47811 ?   ?  'expression tag'      -12 7  
1 8YP8 HIS A 8  ? UNP P47811 ?   ?  'expression tag'      -11 8  
1 8YP8 HIS A 9  ? UNP P47811 ?   ?  'expression tag'      -10 9  
1 8YP8 SER A 10 ? UNP P47811 ?   ?  'expression tag'      -9  10 
1 8YP8 SER A 11 ? UNP P47811 ?   ?  'expression tag'      -8  11 
1 8YP8 GLY A 12 ? UNP P47811 ?   ?  'expression tag'      -7  12 
1 8YP8 LEU A 13 ? UNP P47811 ?   ?  'expression tag'      -6  13 
1 8YP8 VAL A 14 ? UNP P47811 ?   ?  'expression tag'      -5  14 
1 8YP8 PRO A 15 ? UNP P47811 ?   ?  'expression tag'      -4  15 
1 8YP8 ARG A 16 ? UNP P47811 ?   ?  'expression tag'      -3  16 
1 8YP8 GLY A 17 ? UNP P47811 ?   ?  'expression tag'      -2  17 
1 8YP8 SER A 18 ? UNP P47811 ?   ?  'expression tag'      -1  18 
1 8YP8 HIS A 19 ? UNP P47811 ?   ?  'expression tag'      0   19 
2 8YP8 CYS B 16 ? UNP P35236 VAL 52 'engineered mutation' 31  20 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1660  ? 
1 MORE         -7    ? 
1 'SSA (A^2)'  17810 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 80  ? MET A 97  ? SER A 61  MET A 78  1 ? 18 
HELX_P HELX_P2  AA2 SER A 114 ? PHE A 118 ? SER A 95  PHE A 99  5 ? 5  
HELX_P HELX_P3  AA3 ASP A 131 ? GLN A 139 ? ASP A 112 GLN A 120 1 ? 9  
HELX_P HELX_P4  AA4 THR A 142 ? ALA A 163 ? THR A 123 ALA A 144 1 ? 22 
HELX_P HELX_P5  AA5 LYS A 171 ? SER A 173 ? LYS A 152 SER A 154 5 ? 3  
HELX_P HELX_P6  AA6 ALA A 209 ? LEU A 214 ? ALA A 190 LEU A 195 1 ? 6  
HELX_P HELX_P7  AA7 THR A 222 ? GLY A 238 ? THR A 203 GLY A 219 1 ? 17 
HELX_P HELX_P8  AA8 ASP A 246 ? GLY A 259 ? ASP A 227 GLY A 240 1 ? 14 
HELX_P HELX_P9  AA9 GLY A 262 ? LYS A 267 ? GLY A 243 LYS A 248 1 ? 6  
HELX_P HELX_P10 AB1 SER A 271 ? SER A 280 ? SER A 252 SER A 261 1 ? 10 
HELX_P HELX_P11 AB2 ASN A 288 ? VAL A 292 ? ASN A 269 VAL A 273 5 ? 5  
HELX_P HELX_P12 AB3 ASN A 297 ? LEU A 308 ? ASN A 278 LEU A 289 1 ? 12 
HELX_P HELX_P13 AB4 ASP A 311 ? ARG A 315 ? ASP A 292 ARG A 296 5 ? 5  
HELX_P HELX_P14 AB5 THR A 317 ? ALA A 323 ? THR A 298 ALA A 304 1 ? 7  
HELX_P HELX_P15 AB6 HIS A 324 ? ALA A 328 ? HIS A 305 ALA A 309 5 ? 5  
HELX_P HELX_P16 AB7 ASP A 332 ? GLU A 336 ? ASP A 313 GLU A 317 5 ? 5  
HELX_P HELX_P17 AB8 GLN A 344 ? ARG A 349 ? GLN A 325 ARG A 330 5 ? 6  
HELX_P HELX_P18 AB9 LEU A 352 ? SER A 366 ? LEU A 333 SER A 347 1 ? 15 
HELX_P HELX_P19 AC1 LEU B 2   ? ARG B 6   ? LEU B 17  ARG B 21  1 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            138 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            16 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             119 
_struct_conn.ptnr2_auth_asym_id            B 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             31 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.028 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       138 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     B 
_pdbx_modification_feature.modified_residue_label_seq_id      16 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        119 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      B 
_pdbx_modification_feature.modified_residue_auth_seq_id       31 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 5 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 27  ? LEU A 32  ? PHE A 8   LEU A 13  
AA1 2 THR A 35  ? PRO A 40  ? THR A 16  PRO A 21  
AA2 1 TYR A 43  ? SER A 51  ? TYR A 24  SER A 32  
AA2 2 GLY A 55  ? ASP A 62  ? GLY A 36  ASP A 43  
AA2 3 HIS A 67  ? LEU A 74  ? HIS A 48  LEU A 55  
AA2 4 TYR A 122 ? HIS A 126 ? TYR A 103 HIS A 107 
AA2 5 ASP A 107 ? PHE A 109 ? ASP A 88  PHE A 90  
AA3 1 LEU A 175 ? VAL A 177 ? LEU A 156 VAL A 158 
AA3 2 LEU A 183 ? ILE A 185 ? LEU A 164 ILE A 166 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 30  ? N GLN A 11  O TRP A 37  ? O TRP A 18  
AA2 1 2 N GLN A 44  ? N GLN A 25  O PHE A 61  ? O PHE A 42  
AA2 2 3 N ASP A 62  ? N ASP A 43  O HIS A 67  ? O HIS A 48  
AA2 3 4 N LYS A 72  ? N LYS A 53  O LEU A 123 ? O LEU A 104 
AA2 4 5 O VAL A 124 ? O VAL A 105 N ASP A 107 ? N ASP A 88  
AA3 1 2 N ALA A 176 ? N ALA A 157 O LYS A 184 ? O LYS A 165 
# 
_pdbx_entry_details.entry_id                   8YP8 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 14  ? ? 56.04   -124.25 
2 1 ARG A 149 ? ? 84.01   -20.01  
3 1 ASP A 150 ? ? -141.34 49.24   
4 1 TYR A 200 ? ? -35.29  118.06  
5 1 LEU A 289 ? ? -100.85 51.91   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -18 ? A GLY 1   
2  1 Y 1 A SER -17 ? A SER 2   
3  1 Y 1 A SER -16 ? A SER 3   
4  1 Y 1 A HIS -15 ? A HIS 4   
5  1 Y 1 A HIS -14 ? A HIS 5   
6  1 Y 1 A HIS -13 ? A HIS 6   
7  1 Y 1 A HIS -12 ? A HIS 7   
8  1 Y 1 A HIS -11 ? A HIS 8   
9  1 Y 1 A HIS -10 ? A HIS 9   
10 1 Y 1 A SER -9  ? A SER 10  
11 1 Y 1 A SER -8  ? A SER 11  
12 1 Y 1 A GLY -7  ? A GLY 12  
13 1 Y 1 A LEU -6  ? A LEU 13  
14 1 Y 1 A VAL -5  ? A VAL 14  
15 1 Y 1 A PRO -4  ? A PRO 15  
16 1 Y 1 A ARG -3  ? A ARG 16  
17 1 Y 1 A GLY -2  ? A GLY 17  
18 1 Y 1 A SER -1  ? A SER 18  
19 1 Y 1 A HIS 174 ? A HIS 193 
20 1 Y 1 A THR 175 ? A THR 194 
21 1 Y 1 A ASP 176 ? A ASP 195 
22 1 Y 1 A ASP 177 ? A ASP 196 
23 1 Y 1 A GLU 178 ? A GLU 197 
24 1 Y 1 A MET 179 ? A MET 198 
25 1 Y 1 A THR 180 ? A THR 199 
26 1 Y 1 A GLY 181 ? A GLY 200 
27 1 Y 1 A TYR 182 ? A TYR 201 
28 1 Y 1 A VAL 183 ? A VAL 202 
29 1 Y 1 A ALA 184 ? A ALA 203 
30 1 Y 1 A ASP 354 ? A ASP 373 
31 1 Y 1 A GLN 355 ? A GLN 374 
32 1 Y 1 A GLU 356 ? A GLU 375 
33 1 Y 1 A GLU 357 ? A GLU 376 
34 1 Y 1 A MET 358 ? A MET 377 
35 1 Y 1 A GLU 359 ? A GLU 378 
36 1 Y 1 A SER 360 ? A SER 379 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministry of Science and Technology (MoST, China)' China 2019YFA0802500 1 
'Ministry of Science and Technology (MoST, China)' China 2022YFA0806504 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3TG1 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YP8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012201 
_atom_sites.fract_transf_matrix[1][2]   0.007044 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014089 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008170 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . HIS A 1 19  ? 27.436 -50.423 9.838   1.00 59.77  ? 0   HIS A N   1 
ATOM   2    C CA  . HIS A 1 19  ? 26.443 -49.813 10.809  1.00 62.36  ? 0   HIS A CA  1 
ATOM   3    C C   . HIS A 1 19  ? 25.653 -48.706 10.095  1.00 68.89  ? 0   HIS A C   1 
ATOM   4    O O   . HIS A 1 19  ? 26.268 -47.658 9.770   1.00 77.13  ? 0   HIS A O   1 
ATOM   5    C CB  . HIS A 1 19  ? 27.119 -49.266 12.085  1.00 52.63  ? 0   HIS A CB  1 
ATOM   6    C CG  . HIS A 1 19  ? 26.223 -48.380 12.910  1.00 53.61  ? 0   HIS A CG  1 
ATOM   7    N ND1 . HIS A 1 19  ? 25.289 -48.884 13.804  1.00 43.78  ? 0   HIS A ND1 1 
ATOM   8    C CD2 . HIS A 1 19  ? 26.093 -47.029 12.969  1.00 49.25  ? 0   HIS A CD2 1 
ATOM   9    C CE1 . HIS A 1 19  ? 24.651 -47.890 14.380  1.00 45.86  ? 0   HIS A CE1 1 
ATOM   10   N NE2 . HIS A 1 19  ? 25.124 -46.739 13.897  1.00 45.01  ? 0   HIS A NE2 1 
ATOM   11   N N   . MET A 1 20  ? 24.350 -48.926 9.872   1.00 69.83  ? 1   MET A N   1 
ATOM   12   C CA  . MET A 1 20  ? 23.415 -47.976 9.201   1.00 77.62  ? 1   MET A CA  1 
ATOM   13   C C   . MET A 1 20  ? 23.883 -47.722 7.751   1.00 78.27  ? 1   MET A C   1 
ATOM   14   O O   . MET A 1 20  ? 23.518 -46.689 7.153   1.00 70.16  ? 1   MET A O   1 
ATOM   15   C CB  . MET A 1 20  ? 23.303 -46.686 10.025  1.00 73.29  ? 1   MET A CB  1 
ATOM   16   C CG  . MET A 1 20  ? 22.701 -46.959 11.410  1.00 72.18  ? 1   MET A CG  1 
ATOM   17   S SD  . MET A 1 20  ? 22.149 -45.508 12.395  1.00 71.64  ? 1   MET A SD  1 
ATOM   18   C CE  . MET A 1 20  ? 21.144 -44.580 11.232  1.00 74.25  ? 1   MET A CE  1 
ATOM   19   N N   . SER A 1 21  ? 24.632 -48.676 7.189   1.00 86.87  ? 2   SER A N   1 
ATOM   20   C CA  . SER A 1 21  ? 25.067 -48.690 5.770   1.00 91.26  ? 2   SER A CA  1 
ATOM   21   C C   . SER A 1 21  ? 23.863 -49.041 4.897   1.00 96.73  ? 2   SER A C   1 
ATOM   22   O O   . SER A 1 21  ? 23.059 -49.897 5.328   1.00 96.25  ? 2   SER A O   1 
ATOM   23   C CB  . SER A 1 21  ? 26.192 -49.658 5.550   1.00 92.25  ? 2   SER A CB  1 
ATOM   24   O OG  . SER A 1 21  ? 26.644 -49.601 4.209   1.00 98.16  ? 2   SER A OG  1 
ATOM   25   N N   . GLN A 1 22  ? 23.773 -48.407 3.721   1.00 97.00  ? 3   GLN A N   1 
ATOM   26   C CA  . GLN A 1 22  ? 22.704 -48.601 2.702   1.00 87.99  ? 3   GLN A CA  1 
ATOM   27   C C   . GLN A 1 22  ? 22.606 -50.096 2.367   1.00 79.40  ? 3   GLN A C   1 
ATOM   28   O O   . GLN A 1 22  ? 23.664 -50.772 2.333   1.00 73.57  ? 3   GLN A O   1 
ATOM   29   C CB  . GLN A 1 22  ? 23.012 -47.761 1.456   1.00 92.56  ? 3   GLN A CB  1 
ATOM   30   C CG  . GLN A 1 22  ? 21.843 -47.618 0.487   1.00 100.20 ? 3   GLN A CG  1 
ATOM   31   C CD  . GLN A 1 22  ? 20.840 -46.580 0.933   1.00 99.28  ? 3   GLN A CD  1 
ATOM   32   O OE1 . GLN A 1 22  ? 19.687 -46.892 1.237   1.00 91.52  ? 3   GLN A OE1 1 
ATOM   33   N NE2 . GLN A 1 22  ? 21.278 -45.329 0.979   1.00 89.23  ? 3   GLN A NE2 1 
ATOM   34   N N   . GLU A 1 23  ? 21.383 -50.593 2.157   1.00 72.68  ? 4   GLU A N   1 
ATOM   35   C CA  . GLU A 1 23  ? 21.116 -51.973 1.674   1.00 65.67  ? 4   GLU A CA  1 
ATOM   36   C C   . GLU A 1 23  ? 21.772 -52.128 0.301   1.00 54.80  ? 4   GLU A C   1 
ATOM   37   O O   . GLU A 1 23  ? 21.614 -51.226 -0.521  1.00 56.25  ? 4   GLU A O   1 
ATOM   38   C CB  . GLU A 1 23  ? 19.611 -52.234 1.585   1.00 75.54  ? 4   GLU A CB  1 
ATOM   39   C CG  . GLU A 1 23  ? 19.264 -53.640 1.108   1.00 81.23  ? 4   GLU A CG  1 
ATOM   40   C CD  . GLU A 1 23  ? 17.841 -54.106 1.372   1.00 81.09  ? 4   GLU A CD  1 
ATOM   41   O OE1 . GLU A 1 23  ? 16.902 -53.460 0.865   1.00 78.11  ? 4   GLU A OE1 1 
ATOM   42   O OE2 . GLU A 1 23  ? 17.685 -55.123 2.088   1.00 79.08  ? 4   GLU A OE2 1 
ATOM   43   N N   . ARG A 1 24  ? 22.495 -53.218 0.079   1.00 47.95  ? 5   ARG A N   1 
ATOM   44   C CA  . ARG A 1 24  ? 23.247 -53.439 -1.172  1.00 46.01  ? 5   ARG A CA  1 
ATOM   45   C C   . ARG A 1 24  ? 22.245 -53.788 -2.260  1.00 47.73  ? 5   ARG A C   1 
ATOM   46   O O   . ARG A 1 24  ? 21.497 -54.739 -2.106  1.00 52.98  ? 5   ARG A O   1 
ATOM   47   C CB  . ARG A 1 24  ? 24.286 -54.549 -1.037  1.00 39.89  ? 5   ARG A CB  1 
ATOM   48   C CG  . ARG A 1 24  ? 25.169 -54.706 -2.263  1.00 41.65  ? 5   ARG A CG  1 
ATOM   49   C CD  . ARG A 1 24  ? 26.206 -55.793 -2.046  1.00 41.62  ? 5   ARG A CD  1 
ATOM   50   N NE  . ARG A 1 24  ? 27.038 -56.030 -3.217  1.00 40.65  ? 5   ARG A NE  1 
ATOM   51   C CZ  . ARG A 1 24  ? 26.697 -56.748 -4.272  1.00 40.79  ? 5   ARG A CZ  1 
ATOM   52   N NH1 . ARG A 1 24  ? 25.492 -57.289 -4.345  1.00 44.95  ? 5   ARG A NH1 1 
ATOM   53   N NH2 . ARG A 1 24  ? 27.565 -56.916 -5.258  1.00 43.08  ? 5   ARG A NH2 1 
ATOM   54   N N   . PRO A 1 25  ? 22.198 -53.031 -3.379  1.00 45.57  ? 6   PRO A N   1 
ATOM   55   C CA  . PRO A 1 25  ? 21.326 -53.374 -4.490  1.00 39.44  ? 6   PRO A CA  1 
ATOM   56   C C   . PRO A 1 25  ? 21.746 -54.720 -5.065  1.00 35.02  ? 6   PRO A C   1 
ATOM   57   O O   . PRO A 1 25  ? 22.842 -55.147 -4.804  1.00 33.20  ? 6   PRO A O   1 
ATOM   58   C CB  . PRO A 1 25  ? 21.559 -52.289 -5.553  1.00 40.22  ? 6   PRO A CB  1 
ATOM   59   C CG  . PRO A 1 25  ? 22.283 -51.172 -4.839  1.00 41.73  ? 6   PRO A CG  1 
ATOM   60   C CD  . PRO A 1 25  ? 22.955 -51.797 -3.630  1.00 43.20  ? 6   PRO A CD  1 
ATOM   61   N N   . THR A 1 26  ? 20.878 -55.286 -5.898  1.00 32.84  ? 7   THR A N   1 
ATOM   62   C CA  . THR A 1 26  ? 21.214 -56.381 -6.827  1.00 33.35  ? 7   THR A CA  1 
ATOM   63   C C   . THR A 1 26  ? 21.952 -55.777 -8.019  1.00 35.49  ? 7   THR A C   1 
ATOM   64   O O   . THR A 1 26  ? 21.443 -54.808 -8.603  1.00 31.44  ? 7   THR A O   1 
ATOM   65   C CB  . THR A 1 26  ? 19.965 -57.159 -7.254  1.00 34.07  ? 7   THR A CB  1 
ATOM   66   O OG1 . THR A 1 26  ? 19.422 -57.636 -6.024  1.00 33.05  ? 7   THR A OG1 1 
ATOM   67   C CG2 . THR A 1 26  ? 20.260 -58.261 -8.249  1.00 30.24  ? 7   THR A CG2 1 
ATOM   68   N N   . PHE A 1 27  ? 23.112 -56.352 -8.335  1.00 35.19  ? 8   PHE A N   1 
ATOM   69   C CA  . PHE A 1 27  ? 23.998 -55.942 -9.444  1.00 37.19  ? 8   PHE A CA  1 
ATOM   70   C C   . PHE A 1 27  ? 23.803 -56.956 -10.566 1.00 35.66  ? 8   PHE A C   1 
ATOM   71   O O   . PHE A 1 27  ? 23.350 -58.058 -10.295 1.00 44.03  ? 8   PHE A O   1 
ATOM   72   C CB  . PHE A 1 27  ? 25.468 -55.894 -9.000  1.00 35.70  ? 8   PHE A CB  1 
ATOM   73   C CG  . PHE A 1 27  ? 25.846 -54.735 -8.111  1.00 30.84  ? 8   PHE A CG  1 
ATOM   74   C CD1 . PHE A 1 27  ? 25.351 -54.652 -6.825  1.00 31.58  ? 8   PHE A CD1 1 
ATOM   75   C CD2 . PHE A 1 27  ? 26.716 -53.738 -8.547  1.00 30.97  ? 8   PHE A CD2 1 
ATOM   76   C CE1 . PHE A 1 27  ? 25.695 -53.595 -5.990  1.00 31.59  ? 8   PHE A CE1 1 
ATOM   77   C CE2 . PHE A 1 27  ? 27.081 -52.695 -7.701  1.00 31.66  ? 8   PHE A CE2 1 
ATOM   78   C CZ  . PHE A 1 27  ? 26.546 -52.607 -6.434  1.00 30.47  ? 8   PHE A CZ  1 
ATOM   79   N N   . TYR A 1 28  ? 24.122 -56.568 -11.789 1.00 34.15  ? 9   TYR A N   1 
ATOM   80   C CA  . TYR A 1 28  ? 24.162 -57.471 -12.959 1.00 34.65  ? 9   TYR A CA  1 
ATOM   81   C C   . TYR A 1 28  ? 25.404 -57.090 -13.752 1.00 34.78  ? 9   TYR A C   1 
ATOM   82   O O   . TYR A 1 28  ? 25.845 -55.931 -13.684 1.00 42.09  ? 9   TYR A O   1 
ATOM   83   C CB  . TYR A 1 28  ? 22.855 -57.403 -13.764 1.00 34.12  ? 9   TYR A CB  1 
ATOM   84   C CG  . TYR A 1 28  ? 22.601 -56.127 -14.535 1.00 30.80  ? 9   TYR A CG  1 
ATOM   85   C CD1 . TYR A 1 28  ? 22.177 -54.960 -13.917 1.00 32.60  ? 9   TYR A CD1 1 
ATOM   86   C CD2 . TYR A 1 28  ? 22.743 -56.103 -15.909 1.00 31.54  ? 9   TYR A CD2 1 
ATOM   87   C CE1 . TYR A 1 28  ? 21.954 -53.795 -14.647 1.00 30.22  ? 9   TYR A CE1 1 
ATOM   88   C CE2 . TYR A 1 28  ? 22.511 -54.953 -16.648 1.00 30.91  ? 9   TYR A CE2 1 
ATOM   89   C CZ  . TYR A 1 28  ? 22.121 -53.791 -16.016 1.00 29.33  ? 9   TYR A CZ  1 
ATOM   90   O OH  . TYR A 1 28  ? 21.888 -52.662 -16.766 1.00 33.52  ? 9   TYR A OH  1 
ATOM   91   N N   . ARG A 1 29  ? 25.959 -58.049 -14.475 1.00 38.73  ? 10  ARG A N   1 
ATOM   92   C CA  . ARG A 1 29  ? 27.224 -57.829 -15.197 1.00 44.20  ? 10  ARG A CA  1 
ATOM   93   C C   . ARG A 1 29  ? 26.964 -57.875 -16.692 1.00 44.08  ? 10  ARG A C   1 
ATOM   94   O O   . ARG A 1 29  ? 26.126 -58.646 -17.125 1.00 49.33  ? 10  ARG A O   1 
ATOM   95   C CB  . ARG A 1 29  ? 28.240 -58.872 -14.753 1.00 49.43  ? 10  ARG A CB  1 
ATOM   96   C CG  . ARG A 1 29  ? 28.278 -59.081 -13.245 1.00 57.69  ? 10  ARG A CG  1 
ATOM   97   C CD  . ARG A 1 29  ? 29.262 -60.172 -12.877 1.00 67.54  ? 10  ARG A CD  1 
ATOM   98   N NE  . ARG A 1 29  ? 30.493 -60.036 -13.641 1.00 77.01  ? 10  ARG A NE  1 
ATOM   99   C CZ  . ARG A 1 29  ? 31.568 -60.793 -13.485 1.00 85.22  ? 10  ARG A CZ  1 
ATOM   100  N NH1 . ARG A 1 29  ? 31.576 -61.755 -12.575 1.00 91.59  ? 10  ARG A NH1 1 
ATOM   101  N NH2 . ARG A 1 29  ? 32.639 -60.585 -14.231 1.00 80.90  ? 10  ARG A NH2 1 
ATOM   102  N N   . GLN A 1 30  ? 27.599 -56.986 -17.422 1.00 46.02  ? 11  GLN A N   1 
ATOM   103  C CA  . GLN A 1 30  ? 27.517 -56.970 -18.893 1.00 47.18  ? 11  GLN A CA  1 
ATOM   104  C C   . GLN A 1 30  ? 28.898 -56.559 -19.383 1.00 53.11  ? 11  GLN A C   1 
ATOM   105  O O   . GLN A 1 30  ? 29.576 -55.783 -18.681 1.00 46.48  ? 11  GLN A O   1 
ATOM   106  C CB  . GLN A 1 30  ? 26.453 -55.992 -19.384 1.00 44.98  ? 11  GLN A CB  1 
ATOM   107  C CG  . GLN A 1 30  ? 26.651 -54.567 -18.905 1.00 47.35  ? 11  GLN A CG  1 
ATOM   108  C CD  . GLN A 1 30  ? 25.424 -53.742 -19.208 1.00 49.88  ? 11  GLN A CD  1 
ATOM   109  O OE1 . GLN A 1 30  ? 24.838 -53.107 -18.333 1.00 50.71  ? 11  GLN A OE1 1 
ATOM   110  N NE2 . GLN A 1 30  ? 25.009 -53.756 -20.462 1.00 52.94  ? 11  GLN A NE2 1 
ATOM   111  N N   . GLU A 1 31  ? 29.309 -57.037 -20.546 1.00 55.44  ? 12  GLU A N   1 
ATOM   112  C CA  . GLU A 1 31  ? 30.578 -56.548 -21.098 1.00 57.12  ? 12  GLU A CA  1 
ATOM   113  C C   . GLU A 1 31  ? 30.230 -55.514 -22.150 1.00 60.03  ? 12  GLU A C   1 
ATOM   114  O O   . GLU A 1 31  ? 29.620 -55.878 -23.135 1.00 70.61  ? 12  GLU A O   1 
ATOM   115  C CB  . GLU A 1 31  ? 31.399 -57.680 -21.685 1.00 48.23  ? 12  GLU A CB  1 
ATOM   116  C CG  . GLU A 1 31  ? 32.647 -57.146 -22.392 1.00 50.01  ? 12  GLU A CG  1 
ATOM   117  C CD  . GLU A 1 31  ? 33.516 -58.207 -23.047 1.00 50.74  ? 12  GLU A CD  1 
ATOM   118  O OE1 . GLU A 1 31  ? 33.766 -59.278 -22.380 1.00 43.41  ? 12  GLU A OE1 1 
ATOM   119  O OE2 . GLU A 1 31  ? 33.952 -57.963 -24.218 1.00 44.89  ? 12  GLU A OE2 1 
ATOM   120  N N   . LEU A 1 32  ? 30.615 -54.277 -21.933 1.00 74.39  ? 13  LEU A N   1 
ATOM   121  C CA  . LEU A 1 32  ? 30.370 -53.235 -22.947 1.00 86.74  ? 13  LEU A CA  1 
ATOM   122  C C   . LEU A 1 32  ? 31.733 -52.849 -23.481 1.00 96.65  ? 13  LEU A C   1 
ATOM   123  O O   . LEU A 1 32  ? 32.565 -52.373 -22.677 1.00 84.60  ? 13  LEU A O   1 
ATOM   124  C CB  . LEU A 1 32  ? 29.644 -52.053 -22.310 1.00 87.08  ? 13  LEU A CB  1 
ATOM   125  C CG  . LEU A 1 32  ? 28.344 -52.407 -21.592 1.00 89.33  ? 13  LEU A CG  1 
ATOM   126  C CD1 . LEU A 1 32  ? 27.828 -51.219 -20.805 1.00 88.95  ? 13  LEU A CD1 1 
ATOM   127  C CD2 . LEU A 1 32  ? 27.295 -52.903 -22.576 1.00 92.87  ? 13  LEU A CD2 1 
ATOM   128  N N   . ASN A 1 33  ? 31.956 -53.082 -24.772 1.00 103.75 ? 14  ASN A N   1 
ATOM   129  C CA  . ASN A 1 33  ? 33.290 -52.847 -25.377 1.00 104.33 ? 14  ASN A CA  1 
ATOM   130  C C   . ASN A 1 33  ? 34.339 -53.657 -24.601 1.00 102.56 ? 14  ASN A C   1 
ATOM   131  O O   . ASN A 1 33  ? 34.149 -54.879 -24.451 1.00 90.46  ? 14  ASN A O   1 
ATOM   132  C CB  . ASN A 1 33  ? 33.609 -51.349 -25.386 1.00 108.07 ? 14  ASN A CB  1 
ATOM   133  C CG  . ASN A 1 33  ? 32.693 -50.562 -26.295 1.00 105.65 ? 14  ASN A CG  1 
ATOM   134  O OD1 . ASN A 1 33  ? 31.671 -51.072 -26.749 1.00 99.06  ? 14  ASN A OD1 1 
ATOM   135  N ND2 . ASN A 1 33  ? 33.060 -49.322 -26.578 1.00 102.86 ? 14  ASN A ND2 1 
ATOM   136  N N   . LYS A 1 34  ? 35.373 -52.987 -24.093 1.00 100.17 ? 15  LYS A N   1 
ATOM   137  C CA  . LYS A 1 34  ? 36.558 -53.611 -23.459 1.00 102.59 ? 15  LYS A CA  1 
ATOM   138  C C   . LYS A 1 34  ? 36.289 -54.338 -22.136 1.00 88.51  ? 15  LYS A C   1 
ATOM   139  O O   . LYS A 1 34  ? 36.955 -55.365 -21.910 1.00 74.52  ? 15  LYS A O   1 
ATOM   140  C CB  . LYS A 1 34  ? 37.560 -52.507 -23.141 1.00 116.73 ? 15  LYS A CB  1 
ATOM   141  C CG  . LYS A 1 34  ? 38.968 -52.984 -22.813 1.00 122.68 ? 15  LYS A CG  1 
ATOM   142  C CD  . LYS A 1 34  ? 39.954 -51.864 -22.531 1.00 123.28 ? 15  LYS A CD  1 
ATOM   143  C CE  . LYS A 1 34  ? 40.143 -50.921 -23.703 1.00 119.44 ? 15  LYS A CE  1 
ATOM   144  N NZ  . LYS A 1 34  ? 39.087 -49.882 -23.757 1.00 116.56 ? 15  LYS A NZ  1 
ATOM   145  N N   . THR A 1 35  ? 35.460 -53.810 -21.237 1.00 83.63  ? 16  THR A N   1 
ATOM   146  C CA  . THR A 1 35  ? 35.477 -54.323 -19.835 1.00 72.86  ? 16  THR A CA  1 
ATOM   147  C C   . THR A 1 35  ? 34.111 -54.691 -19.251 1.00 59.60  ? 16  THR A C   1 
ATOM   148  O O   . THR A 1 35  ? 33.078 -54.244 -19.755 1.00 50.39  ? 16  THR A O   1 
ATOM   149  C CB  . THR A 1 35  ? 36.150 -53.315 -18.902 1.00 81.93  ? 16  THR A CB  1 
ATOM   150  O OG1 . THR A 1 35  ? 35.350 -52.130 -18.876 1.00 78.74  ? 16  THR A OG1 1 
ATOM   151  C CG2 . THR A 1 35  ? 37.565 -52.979 -19.317 1.00 81.46  ? 16  THR A CG2 1 
ATOM   152  N N   . ILE A 1 36  ? 34.157 -55.511 -18.203 1.00 53.07  ? 17  ILE A N   1 
ATOM   153  C CA  . ILE A 1 36  ? 32.944 -55.969 -17.476 1.00 57.01  ? 17  ILE A CA  1 
ATOM   154  C C   . ILE A 1 36  ? 32.388 -54.827 -16.627 1.00 51.10  ? 17  ILE A C   1 
ATOM   155  O O   . ILE A 1 36  ? 33.096 -54.341 -15.758 1.00 59.69  ? 17  ILE A O   1 
ATOM   156  C CB  . ILE A 1 36  ? 33.240 -57.210 -16.626 1.00 57.41  ? 17  ILE A CB  1 
ATOM   157  C CG1 . ILE A 1 36  ? 33.659 -58.389 -17.505 1.00 63.51  ? 17  ILE A CG1 1 
ATOM   158  C CG2 . ILE A 1 36  ? 32.029 -57.552 -15.770 1.00 59.72  ? 17  ILE A CG2 1 
ATOM   159  C CD1 . ILE A 1 36  ? 32.623 -58.776 -18.547 1.00 67.63  ? 17  ILE A CD1 1 
ATOM   160  N N   . TRP A 1 37  ? 31.150 -54.435 -16.892 1.00 45.36  ? 18  TRP A N   1 
ATOM   161  C CA  . TRP A 1 37  ? 30.401 -53.451 -16.076 1.00 40.31  ? 18  TRP A CA  1 
ATOM   162  C C   . TRP A 1 37  ? 29.478 -54.220 -15.144 1.00 37.92  ? 18  TRP A C   1 
ATOM   163  O O   . TRP A 1 37  ? 28.713 -55.071 -15.631 1.00 37.76  ? 18  TRP A O   1 
ATOM   164  C CB  . TRP A 1 37  ? 29.628 -52.481 -16.963 1.00 41.86  ? 18  TRP A CB  1 
ATOM   165  C CG  . TRP A 1 37  ? 30.521 -51.515 -17.665 1.00 44.31  ? 18  TRP A CG  1 
ATOM   166  C CD1 . TRP A 1 37  ? 31.543 -51.818 -18.517 1.00 48.79  ? 18  TRP A CD1 1 
ATOM   167  C CD2 . TRP A 1 37  ? 30.504 -50.083 -17.547 1.00 42.47  ? 18  TRP A CD2 1 
ATOM   168  N NE1 . TRP A 1 37  ? 32.153 -50.672 -18.945 1.00 47.44  ? 18  TRP A NE1 1 
ATOM   169  C CE2 . TRP A 1 37  ? 31.529 -49.592 -18.385 1.00 43.42  ? 18  TRP A CE2 1 
ATOM   170  C CE3 . TRP A 1 37  ? 29.740 -49.174 -16.810 1.00 35.08  ? 18  TRP A CE3 1 
ATOM   171  C CZ2 . TRP A 1 37  ? 31.789 -48.231 -18.521 1.00 39.21  ? 18  TRP A CZ2 1 
ATOM   172  C CZ3 . TRP A 1 37  ? 29.990 -47.836 -16.955 1.00 33.25  ? 18  TRP A CZ3 1 
ATOM   173  C CH2 . TRP A 1 37  ? 31.001 -47.370 -17.795 1.00 36.85  ? 18  TRP A CH2 1 
ATOM   174  N N   . GLU A 1 38  ? 29.587 -53.934 -13.855 1.00 34.51  ? 19  GLU A N   1 
ATOM   175  C CA  . GLU A 1 38  ? 28.746 -54.549 -12.809 1.00 34.48  ? 19  GLU A CA  1 
ATOM   176  C C   . GLU A 1 38  ? 28.115 -53.377 -12.076 1.00 32.87  ? 19  GLU A C   1 
ATOM   177  O O   . GLU A 1 38  ? 28.853 -52.626 -11.380 1.00 33.47  ? 19  GLU A O   1 
ATOM   178  C CB  . GLU A 1 38  ? 29.611 -55.484 -11.962 1.00 37.36  ? 19  GLU A CB  1 
ATOM   179  C CG  . GLU A 1 38  ? 28.833 -56.347 -10.998 1.00 41.51  ? 19  GLU A CG  1 
ATOM   180  C CD  . GLU A 1 38  ? 29.620 -57.519 -10.416 1.00 45.17  ? 19  GLU A CD  1 
ATOM   181  O OE1 . GLU A 1 38  ? 30.861 -57.598 -10.625 1.00 45.25  ? 19  GLU A OE1 1 
ATOM   182  O OE2 . GLU A 1 38  ? 28.979 -58.353 -9.757  1.00 43.21  ? 19  GLU A OE2 1 
ATOM   183  N N   . VAL A 1 39  ? 26.826 -53.162 -12.322 1.00 30.54  ? 20  VAL A N   1 
ATOM   184  C CA  . VAL A 1 39  ? 26.067 -51.992 -11.812 1.00 30.44  ? 20  VAL A CA  1 
ATOM   185  C C   . VAL A 1 39  ? 24.767 -52.485 -11.185 1.00 28.75  ? 20  VAL A C   1 
ATOM   186  O O   . VAL A 1 39  ? 24.311 -53.565 -11.512 1.00 28.28  ? 20  VAL A O   1 
ATOM   187  C CB  . VAL A 1 39  ? 25.804 -50.996 -12.951 1.00 34.03  ? 20  VAL A CB  1 
ATOM   188  C CG1 . VAL A 1 39  ? 27.104 -50.651 -13.692 1.00 31.55  ? 20  VAL A CG1 1 
ATOM   189  C CG2 . VAL A 1 39  ? 24.735 -51.529 -13.906 1.00 34.15  ? 20  VAL A CG2 1 
ATOM   190  N N   . PRO A 1 40  ? 24.169 -51.721 -10.250 1.00 25.83  ? 21  PRO A N   1 
ATOM   191  C CA  . PRO A 1 40  ? 22.839 -52.010 -9.737  1.00 28.17  ? 21  PRO A CA  1 
ATOM   192  C C   . PRO A 1 40  ? 21.790 -52.120 -10.850 1.00 32.13  ? 21  PRO A C   1 
ATOM   193  O O   . PRO A 1 40  ? 21.917 -51.438 -11.852 1.00 30.85  ? 21  PRO A O   1 
ATOM   194  C CB  . PRO A 1 40  ? 22.523 -50.779 -8.875  1.00 26.98  ? 21  PRO A CB  1 
ATOM   195  C CG  . PRO A 1 40  ? 23.878 -50.308 -8.421  1.00 26.61  ? 21  PRO A CG  1 
ATOM   196  C CD  . PRO A 1 40  ? 24.768 -50.528 -9.620  1.00 26.80  ? 21  PRO A CD  1 
ATOM   197  N N   . GLU A 1 41  ? 20.764 -52.946 -10.649 1.00 32.97  ? 22  GLU A N   1 
ATOM   198  C CA  . GLU A 1 41  ? 19.697 -53.118 -11.676 1.00 34.77  ? 22  GLU A CA  1 
ATOM   199  C C   . GLU A 1 41  ? 18.930 -51.794 -11.851 1.00 31.96  ? 22  GLU A C   1 
ATOM   200  O O   . GLU A 1 41  ? 18.297 -51.602 -12.873 1.00 28.22  ? 22  GLU A O   1 
ATOM   201  C CB  . GLU A 1 41  ? 18.798 -54.293 -11.323 1.00 33.16  ? 22  GLU A CB  1 
ATOM   202  C CG  . GLU A 1 41  ? 18.142 -54.204 -9.971  1.00 36.64  ? 22  GLU A CG  1 
ATOM   203  C CD  . GLU A 1 41  ? 17.501 -55.538 -9.603  1.00 38.23  ? 22  GLU A CD  1 
ATOM   204  O OE1 . GLU A 1 41  ? 17.354 -56.392 -10.505 1.00 37.60  ? 22  GLU A OE1 1 
ATOM   205  O OE2 . GLU A 1 41  ? 17.161 -55.717 -8.431  1.00 37.51  ? 22  GLU A OE2 1 
ATOM   206  N N   . ARG A 1 42  ? 19.015 -50.900 -10.881 1.00 30.77  ? 23  ARG A N   1 
ATOM   207  C CA  . ARG A 1 42  ? 18.503 -49.525 -11.015 1.00 30.98  ? 23  ARG A CA  1 
ATOM   208  C C   . ARG A 1 42  ? 18.910 -48.929 -12.377 1.00 32.34  ? 23  ARG A C   1 
ATOM   209  O O   . ARG A 1 42  ? 18.104 -48.215 -12.955 1.00 31.48  ? 23  ARG A O   1 
ATOM   210  C CB  . ARG A 1 42  ? 19.093 -48.720 -9.864  1.00 33.11  ? 23  ARG A CB  1 
ATOM   211  C CG  . ARG A 1 42  ? 18.940 -47.226 -10.033 1.00 35.15  ? 23  ARG A CG  1 
ATOM   212  C CD  . ARG A 1 42  ? 19.566 -46.551 -8.856  1.00 33.43  ? 23  ARG A CD  1 
ATOM   213  N NE  . ARG A 1 42  ? 19.450 -45.114 -8.998  1.00 31.79  ? 23  ARG A NE  1 
ATOM   214  C CZ  . ARG A 1 42  ? 19.903 -44.241 -8.095  1.00 34.73  ? 23  ARG A CZ  1 
ATOM   215  N NH1 . ARG A 1 42  ? 20.522 -44.666 -7.003  1.00 30.36  ? 23  ARG A NH1 1 
ATOM   216  N NH2 . ARG A 1 42  ? 19.752 -42.943 -8.296  1.00 33.91  ? 23  ARG A NH2 1 
ATOM   217  N N   . TYR A 1 43  ? 20.132 -49.190 -12.864 1.00 29.84  ? 24  TYR A N   1 
ATOM   218  C CA  . TYR A 1 43  ? 20.686 -48.577 -14.103 1.00 29.42  ? 24  TYR A CA  1 
ATOM   219  C C   . TYR A 1 43  ? 20.533 -49.515 -15.298 1.00 29.93  ? 24  TYR A C   1 
ATOM   220  O O   . TYR A 1 43  ? 21.107 -50.648 -15.303 1.00 33.84  ? 24  TYR A O   1 
ATOM   221  C CB  . TYR A 1 43  ? 22.140 -48.155 -13.880 1.00 28.00  ? 24  TYR A CB  1 
ATOM   222  C CG  . TYR A 1 43  ? 22.293 -47.180 -12.737 1.00 27.32  ? 24  TYR A CG  1 
ATOM   223  C CD1 . TYR A 1 43  ? 21.796 -45.890 -12.811 1.00 25.60  ? 24  TYR A CD1 1 
ATOM   224  C CD2 . TYR A 1 43  ? 22.881 -47.580 -11.548 1.00 27.76  ? 24  TYR A CD2 1 
ATOM   225  C CE1 . TYR A 1 43  ? 21.895 -45.024 -11.742 1.00 25.77  ? 24  TYR A CE1 1 
ATOM   226  C CE2 . TYR A 1 43  ? 22.979 -46.732 -10.467 1.00 24.53  ? 24  TYR A CE2 1 
ATOM   227  C CZ  . TYR A 1 43  ? 22.531 -45.439 -10.580 1.00 24.92  ? 24  TYR A CZ  1 
ATOM   228  O OH  . TYR A 1 43  ? 22.680 -44.622 -9.503  1.00 24.11  ? 24  TYR A OH  1 
ATOM   229  N N   . GLN A 1 44  ? 19.825 -49.043 -16.324 1.00 30.55  ? 25  GLN A N   1 
ATOM   230  C CA  . GLN A 1 44  ? 19.348 -49.896 -17.450 1.00 33.36  ? 25  GLN A CA  1 
ATOM   231  C C   . GLN A 1 44  ? 19.733 -49.273 -18.791 1.00 33.09  ? 25  GLN A C   1 
ATOM   232  O O   . GLN A 1 44  ? 19.914 -48.043 -18.871 1.00 34.08  ? 25  GLN A O   1 
ATOM   233  C CB  . GLN A 1 44  ? 17.830 -50.073 -17.372 1.00 33.22  ? 25  GLN A CB  1 
ATOM   234  C CG  . GLN A 1 44  ? 17.379 -50.877 -16.166 1.00 32.42  ? 25  GLN A CG  1 
ATOM   235  C CD  . GLN A 1 44  ? 17.805 -52.322 -16.242 1.00 33.92  ? 25  GLN A CD  1 
ATOM   236  O OE1 . GLN A 1 44  ? 17.741 -52.965 -17.285 1.00 31.73  ? 25  GLN A OE1 1 
ATOM   237  N NE2 . GLN A 1 44  ? 18.228 -52.856 -15.110 1.00 34.45  ? 25  GLN A NE2 1 
ATOM   238  N N   . ASN A 1 45  ? 19.838 -50.116 -19.806 1.00 35.62  ? 26  ASN A N   1 
ATOM   239  C CA  . ASN A 1 45  ? 20.062 -49.697 -21.210 1.00 38.43  ? 26  ASN A CA  1 
ATOM   240  C C   . ASN A 1 45  ? 21.356 -48.873 -21.261 1.00 36.69  ? 26  ASN A C   1 
ATOM   241  O O   . ASN A 1 45  ? 21.373 -47.786 -21.832 1.00 33.98  ? 26  ASN A O   1 
ATOM   242  C CB  . ASN A 1 45  ? 18.797 -49.029 -21.764 1.00 44.56  ? 26  ASN A CB  1 
ATOM   243  C CG  . ASN A 1 45  ? 17.571 -49.933 -21.710 1.00 50.57  ? 26  ASN A CG  1 
ATOM   244  O OD1 . ASN A 1 45  ? 17.655 -51.163 -21.839 1.00 58.46  ? 26  ASN A OD1 1 
ATOM   245  N ND2 . ASN A 1 45  ? 16.408 -49.336 -21.517 1.00 48.74  ? 26  ASN A ND2 1 
ATOM   246  N N   . LEU A 1 46  ? 22.419 -49.392 -20.653 1.00 36.71  ? 27  LEU A N   1 
ATOM   247  C CA  . LEU A 1 46  ? 23.754 -48.762 -20.717 1.00 37.87  ? 27  LEU A CA  1 
ATOM   248  C C   . LEU A 1 46  ? 24.216 -48.729 -22.175 1.00 40.70  ? 27  LEU A C   1 
ATOM   249  O O   . LEU A 1 46  ? 24.064 -49.757 -22.891 1.00 36.38  ? 27  LEU A O   1 
ATOM   250  C CB  . LEU A 1 46  ? 24.744 -49.536 -19.850 1.00 36.84  ? 27  LEU A CB  1 
ATOM   251  C CG  . LEU A 1 46  ? 24.801 -49.093 -18.396 1.00 37.73  ? 27  LEU A CG  1 
ATOM   252  C CD1 . LEU A 1 46  ? 23.487 -49.429 -17.717 1.00 38.79  ? 27  LEU A CD1 1 
ATOM   253  C CD2 . LEU A 1 46  ? 25.986 -49.748 -17.674 1.00 37.29  ? 27  LEU A CD2 1 
ATOM   254  N N   . SER A 1 47  ? 24.813 -47.609 -22.563 1.00 41.64  ? 28  SER A N   1 
ATOM   255  C CA  . SER A 1 47  ? 25.295 -47.369 -23.941 1.00 43.63  ? 28  SER A CA  1 
ATOM   256  C C   . SER A 1 47  ? 26.611 -46.600 -23.892 1.00 43.63  ? 28  SER A C   1 
ATOM   257  O O   . SER A 1 47  ? 26.668 -45.529 -23.305 1.00 43.83  ? 28  SER A O   1 
ATOM   258  C CB  . SER A 1 47  ? 24.246 -46.627 -24.704 1.00 45.64  ? 28  SER A CB  1 
ATOM   259  O OG  . SER A 1 47  ? 24.731 -46.305 -25.991 1.00 53.09  ? 28  SER A OG  1 
ATOM   260  N N   . PRO A 1 48  ? 27.714 -47.131 -24.469 1.00 48.13  ? 29  PRO A N   1 
ATOM   261  C CA  . PRO A 1 48  ? 28.993 -46.425 -24.495 1.00 46.73  ? 29  PRO A CA  1 
ATOM   262  C C   . PRO A 1 48  ? 28.862 -45.004 -25.040 1.00 45.90  ? 29  PRO A C   1 
ATOM   263  O O   . PRO A 1 48  ? 28.143 -44.813 -25.976 1.00 44.34  ? 29  PRO A O   1 
ATOM   264  C CB  . PRO A 1 48  ? 29.850 -47.261 -25.444 1.00 48.37  ? 29  PRO A CB  1 
ATOM   265  C CG  . PRO A 1 48  ? 29.306 -48.660 -25.288 1.00 48.23  ? 29  PRO A CG  1 
ATOM   266  C CD  . PRO A 1 48  ? 27.816 -48.471 -25.067 1.00 51.95  ? 29  PRO A CD  1 
ATOM   267  N N   . VAL A 1 49  ? 29.509 -44.051 -24.383 1.00 49.45  ? 30  VAL A N   1 
ATOM   268  C CA  . VAL A 1 49  ? 29.534 -42.622 -24.798 1.00 54.58  ? 30  VAL A CA  1 
ATOM   269  C C   . VAL A 1 49  ? 31.005 -42.199 -24.898 1.00 58.10  ? 30  VAL A C   1 
ATOM   270  O O   . VAL A 1 49  ? 31.268 -41.001 -25.062 1.00 62.29  ? 30  VAL A O   1 
ATOM   271  C CB  . VAL A 1 49  ? 28.687 -41.778 -23.822 1.00 56.03  ? 30  VAL A CB  1 
ATOM   272  C CG1 . VAL A 1 49  ? 28.983 -40.287 -23.867 1.00 59.32  ? 30  VAL A CG1 1 
ATOM   273  C CG2 . VAL A 1 49  ? 27.201 -42.025 -24.049 1.00 58.75  ? 30  VAL A CG2 1 
ATOM   274  N N   . GLY A 1 50  ? 31.933 -43.155 -24.849 1.00 62.29  ? 31  GLY A N   1 
ATOM   275  C CA  . GLY A 1 50  ? 33.365 -42.896 -25.100 1.00 80.71  ? 31  GLY A CA  1 
ATOM   276  C C   . GLY A 1 50  ? 34.240 -43.090 -23.870 1.00 87.65  ? 31  GLY A C   1 
ATOM   277  O O   . GLY A 1 50  ? 33.721 -43.033 -22.731 1.00 77.96  ? 31  GLY A O   1 
ATOM   278  N N   . SER A 1 51  ? 35.539 -43.308 -24.111 1.00 94.67  ? 32  SER A N   1 
ATOM   279  C CA  . SER A 1 51  ? 36.556 -43.658 -23.085 1.00 94.53  ? 32  SER A CA  1 
ATOM   280  C C   . SER A 1 51  ? 37.618 -42.548 -22.996 1.00 98.48  ? 32  SER A C   1 
ATOM   281  O O   . SER A 1 51  ? 38.176 -42.169 -24.051 1.00 92.94  ? 32  SER A O   1 
ATOM   282  C CB  . SER A 1 51  ? 37.153 -45.015 -23.391 1.00 88.22  ? 32  SER A CB  1 
ATOM   283  O OG  . SER A 1 51  ? 38.007 -45.447 -22.347 1.00 89.39  ? 32  SER A OG  1 
ATOM   284  N N   . GLY A 1 52  ? 37.839 -42.017 -21.786 1.00 99.89  ? 33  GLY A N   1 
ATOM   285  C CA  . GLY A 1 52  ? 38.934 -41.082 -21.453 1.00 95.01  ? 33  GLY A CA  1 
ATOM   286  C C   . GLY A 1 52  ? 40.171 -41.840 -20.998 1.00 95.57  ? 33  GLY A C   1 
ATOM   287  O O   . GLY A 1 52  ? 40.172 -43.089 -21.093 1.00 87.40  ? 33  GLY A O   1 
ATOM   288  N N   . ALA A 1 53  ? 41.191 -41.122 -20.517 1.00 99.13  ? 34  ALA A N   1 
ATOM   289  C CA  . ALA A 1 53  ? 42.490 -41.692 -20.081 1.00 93.84  ? 34  ALA A CA  1 
ATOM   290  C C   . ALA A 1 53  ? 42.334 -42.383 -18.717 1.00 90.91  ? 34  ALA A C   1 
ATOM   291  O O   . ALA A 1 53  ? 43.093 -43.329 -18.437 1.00 75.73  ? 34  ALA A O   1 
ATOM   292  C CB  . ALA A 1 53  ? 43.542 -40.607 -20.035 1.00 93.60  ? 34  ALA A CB  1 
ATOM   293  N N   . TYR A 1 54  ? 41.395 -41.926 -17.883 1.00 89.60  ? 35  TYR A N   1 
ATOM   294  C CA  . TYR A 1 54  ? 41.276 -42.371 -16.467 1.00 88.64  ? 35  TYR A CA  1 
ATOM   295  C C   . TYR A 1 54  ? 40.045 -43.261 -16.274 1.00 77.67  ? 35  TYR A C   1 
ATOM   296  O O   . TYR A 1 54  ? 39.941 -43.919 -15.209 1.00 80.10  ? 35  TYR A O   1 
ATOM   297  C CB  . TYR A 1 54  ? 41.278 -41.156 -15.536 1.00 93.84  ? 35  TYR A CB  1 
ATOM   298  C CG  . TYR A 1 54  ? 42.620 -40.472 -15.449 1.00 97.86  ? 35  TYR A CG  1 
ATOM   299  C CD1 . TYR A 1 54  ? 43.658 -41.017 -14.698 1.00 101.98 ? 35  TYR A CD1 1 
ATOM   300  C CD2 . TYR A 1 54  ? 42.865 -39.301 -16.151 1.00 90.57  ? 35  TYR A CD2 1 
ATOM   301  C CE1 . TYR A 1 54  ? 44.897 -40.398 -14.624 1.00 99.93  ? 35  TYR A CE1 1 
ATOM   302  C CE2 . TYR A 1 54  ? 44.094 -38.667 -16.087 1.00 93.19  ? 35  TYR A CE2 1 
ATOM   303  C CZ  . TYR A 1 54  ? 45.111 -39.218 -15.324 1.00 103.93 ? 35  TYR A CZ  1 
ATOM   304  O OH  . TYR A 1 54  ? 46.315 -38.577 -15.276 1.00 112.97 ? 35  TYR A OH  1 
ATOM   305  N N   . GLY A 1 55  ? 39.157 -43.308 -17.266 1.00 63.48  ? 36  GLY A N   1 
ATOM   306  C CA  . GLY A 1 55  ? 37.857 -43.973 -17.111 1.00 63.15  ? 36  GLY A CA  1 
ATOM   307  C C   . GLY A 1 55  ? 37.094 -44.108 -18.413 1.00 63.43  ? 36  GLY A C   1 
ATOM   308  O O   . GLY A 1 55  ? 37.491 -43.490 -19.437 1.00 66.09  ? 36  GLY A O   1 
ATOM   309  N N   . SER A 1 56  ? 36.024 -44.900 -18.345 1.00 55.90  ? 37  SER A N   1 
ATOM   310  C CA  . SER A 1 56  ? 35.094 -45.227 -19.453 1.00 48.95  ? 37  SER A CA  1 
ATOM   311  C C   . SER A 1 56  ? 33.697 -44.766 -19.042 1.00 42.76  ? 37  SER A C   1 
ATOM   312  O O   . SER A 1 56  ? 33.364 -44.919 -17.860 1.00 41.09  ? 37  SER A O   1 
ATOM   313  C CB  . SER A 1 56  ? 35.144 -46.700 -19.739 1.00 49.44  ? 37  SER A CB  1 
ATOM   314  O OG  . SER A 1 56  ? 34.525 -46.974 -20.976 1.00 60.11  ? 37  SER A OG  1 
ATOM   315  N N   . VAL A 1 57  ? 32.936 -44.168 -19.952 1.00 38.61  ? 38  VAL A N   1 
ATOM   316  C CA  . VAL A 1 57  ? 31.606 -43.568 -19.649 1.00 36.48  ? 38  VAL A CA  1 
ATOM   317  C C   . VAL A 1 57  ? 30.521 -44.211 -20.516 1.00 37.29  ? 38  VAL A C   1 
ATOM   318  O O   . VAL A 1 57  ? 30.716 -44.316 -21.756 1.00 38.52  ? 38  VAL A O   1 
ATOM   319  C CB  . VAL A 1 57  ? 31.619 -42.045 -19.827 1.00 39.62  ? 38  VAL A CB  1 
ATOM   320  C CG1 . VAL A 1 57  ? 30.262 -41.445 -19.445 1.00 39.11  ? 38  VAL A CG1 1 
ATOM   321  C CG2 . VAL A 1 57  ? 32.742 -41.406 -19.015 1.00 38.85  ? 38  VAL A CG2 1 
ATOM   322  N N   . CYS A 1 58  ? 29.429 -44.635 -19.869 1.00 33.84  ? 39  CYS A N   1 
ATOM   323  C CA  . CYS A 1 58  ? 28.158 -45.031 -20.530 1.00 31.61  ? 39  CYS A CA  1 
ATOM   324  C C   . CYS A 1 58  ? 27.034 -44.108 -20.096 1.00 30.97  ? 39  CYS A C   1 
ATOM   325  O O   . CYS A 1 58  ? 27.035 -43.684 -18.925 1.00 32.53  ? 39  CYS A O   1 
ATOM   326  C CB  . CYS A 1 58  ? 27.712 -46.428 -20.144 1.00 33.95  ? 39  CYS A CB  1 
ATOM   327  S SG  . CYS A 1 58  ? 28.765 -47.714 -20.854 1.00 40.82  ? 39  CYS A SG  1 
ATOM   328  N N   . ALA A 1 59  ? 26.093 -43.860 -20.999 1.00 29.46  ? 40  ALA A N   1 
ATOM   329  C CA  . ALA A 1 59  ? 24.770 -43.281 -20.687 1.00 31.73  ? 40  ALA A CA  1 
ATOM   330  C C   . ALA A 1 59  ? 23.877 -44.414 -20.195 1.00 33.47  ? 40  ALA A C   1 
ATOM   331  O O   . ALA A 1 59  ? 24.005 -45.549 -20.693 1.00 36.75  ? 40  ALA A O   1 
ATOM   332  C CB  . ALA A 1 59  ? 24.177 -42.609 -21.901 1.00 33.26  ? 40  ALA A CB  1 
ATOM   333  N N   . ALA A 1 60  ? 22.998 -44.130 -19.252 1.00 32.93  ? 41  ALA A N   1 
ATOM   334  C CA  . ALA A 1 60  ? 22.100 -45.166 -18.707 1.00 36.82  ? 41  ALA A CA  1 
ATOM   335  C C   . ALA A 1 60  ? 20.790 -44.510 -18.351 1.00 33.11  ? 41  ALA A C   1 
ATOM   336  O O   . ALA A 1 60  ? 20.795 -43.310 -18.145 1.00 37.46  ? 41  ALA A O   1 
ATOM   337  C CB  . ALA A 1 60  ? 22.716 -45.833 -17.484 1.00 38.31  ? 41  ALA A CB  1 
ATOM   338  N N   . PHE A 1 61  ? 19.746 -45.317 -18.218 1.00 35.25  ? 42  PHE A N   1 
ATOM   339  C CA  . PHE A 1 61  ? 18.443 -44.902 -17.666 1.00 34.17  ? 42  PHE A CA  1 
ATOM   340  C C   . PHE A 1 61  ? 18.420 -45.254 -16.173 1.00 32.04  ? 42  PHE A C   1 
ATOM   341  O O   . PHE A 1 61  ? 18.536 -46.420 -15.774 1.00 36.93  ? 42  PHE A O   1 
ATOM   342  C CB  . PHE A 1 61  ? 17.290 -45.513 -18.473 1.00 36.54  ? 42  PHE A CB  1 
ATOM   343  C CG  . PHE A 1 61  ? 15.943 -45.040 -17.988 1.00 38.03  ? 42  PHE A CG  1 
ATOM   344  C CD1 . PHE A 1 61  ? 15.534 -43.738 -18.209 1.00 38.87  ? 42  PHE A CD1 1 
ATOM   345  C CD2 . PHE A 1 61  ? 15.110 -45.880 -17.269 1.00 40.46  ? 42  PHE A CD2 1 
ATOM   346  C CE1 . PHE A 1 61  ? 14.300 -43.293 -17.748 1.00 43.90  ? 42  PHE A CE1 1 
ATOM   347  C CE2 . PHE A 1 61  ? 13.877 -45.437 -16.812 1.00 44.46  ? 42  PHE A CE2 1 
ATOM   348  C CZ  . PHE A 1 61  ? 13.473 -44.139 -17.046 1.00 44.42  ? 42  PHE A CZ  1 
ATOM   349  N N   . ASP A 1 62  ? 18.305 -44.226 -15.350 1.00 28.90  ? 43  ASP A N   1 
ATOM   350  C CA  . ASP A 1 62  ? 18.175 -44.358 -13.886 1.00 32.56  ? 43  ASP A CA  1 
ATOM   351  C C   . ASP A 1 62  ? 16.685 -44.549 -13.585 1.00 34.84  ? 43  ASP A C   1 
ATOM   352  O O   . ASP A 1 62  ? 15.929 -43.550 -13.560 1.00 33.78  ? 43  ASP A O   1 
ATOM   353  C CB  . ASP A 1 62  ? 18.788 -43.156 -13.171 1.00 29.97  ? 43  ASP A CB  1 
ATOM   354  C CG  . ASP A 1 62  ? 18.663 -43.282 -11.672 1.00 31.06  ? 43  ASP A CG  1 
ATOM   355  O OD1 . ASP A 1 62  ? 17.992 -44.193 -11.263 1.00 32.03  ? 43  ASP A OD1 1 
ATOM   356  O OD2 . ASP A 1 62  ? 19.261 -42.481 -10.939 1.00 30.33  ? 43  ASP A OD2 1 
ATOM   357  N N   . THR A 1 63  ? 16.295 -45.801 -13.367 1.00 32.27  ? 44  THR A N   1 
ATOM   358  C CA  . THR A 1 63  ? 14.893 -46.202 -13.103 1.00 29.58  ? 44  THR A CA  1 
ATOM   359  C C   . THR A 1 63  ? 14.465 -45.627 -11.755 1.00 28.24  ? 44  THR A C   1 
ATOM   360  O O   . THR A 1 63  ? 13.286 -45.543 -11.499 1.00 30.46  ? 44  THR A O   1 
ATOM   361  C CB  . THR A 1 63  ? 14.716 -47.724 -13.130 1.00 27.92  ? 44  THR A CB  1 
ATOM   362  O OG1 . THR A 1 63  ? 15.481 -48.294 -12.068 1.00 29.87  ? 44  THR A OG1 1 
ATOM   363  C CG2 . THR A 1 63  ? 15.095 -48.347 -14.459 1.00 26.80  ? 44  THR A CG2 1 
ATOM   364  N N   . LYS A 1 64  ? 15.380 -45.235 -10.885 1.00 32.26  ? 45  LYS A N   1 
ATOM   365  C CA  . LYS A 1 64  ? 14.942 -44.649 -9.590  1.00 38.36  ? 45  LYS A CA  1 
ATOM   366  C C   . LYS A 1 64  ? 14.461 -43.192 -9.772  1.00 37.23  ? 45  LYS A C   1 
ATOM   367  O O   . LYS A 1 64  ? 13.524 -42.818 -9.092  1.00 35.00  ? 45  LYS A O   1 
ATOM   368  C CB  . LYS A 1 64  ? 16.049 -44.748 -8.547  1.00 43.56  ? 45  LYS A CB  1 
ATOM   369  C CG  . LYS A 1 64  ? 15.605 -44.371 -7.145  1.00 49.43  ? 45  LYS A CG  1 
ATOM   370  C CD  . LYS A 1 64  ? 16.737 -43.987 -6.225  1.00 59.85  ? 45  LYS A CD  1 
ATOM   371  C CE  . LYS A 1 64  ? 16.276 -42.989 -5.175  1.00 65.80  ? 45  LYS A CE  1 
ATOM   372  N NZ  . LYS A 1 64  ? 17.170 -42.968 -3.995  1.00 69.81  ? 45  LYS A NZ  1 
ATOM   373  N N   . THR A 1 65  ? 15.099 -42.397 -10.628 1.00 37.36  ? 46  THR A N   1 
ATOM   374  C CA  . THR A 1 65  ? 14.810 -40.942 -10.794 1.00 40.75  ? 46  THR A CA  1 
ATOM   375  C C   . THR A 1 65  ? 14.051 -40.715 -12.109 1.00 43.94  ? 46  THR A C   1 
ATOM   376  O O   . THR A 1 65  ? 13.438 -39.644 -12.268 1.00 46.89  ? 46  THR A O   1 
ATOM   377  C CB  . THR A 1 65  ? 16.089 -40.091 -10.771 1.00 38.32  ? 46  THR A CB  1 
ATOM   378  O OG1 . THR A 1 65  ? 16.949 -40.541 -11.819 1.00 40.14  ? 46  THR A OG1 1 
ATOM   379  C CG2 . THR A 1 65  ? 16.855 -40.161 -9.472  1.00 38.26  ? 46  THR A CG2 1 
ATOM   380  N N   . GLY A 1 66  ? 14.076 -41.687 -13.017 1.00 43.87  ? 47  GLY A N   1 
ATOM   381  C CA  . GLY A 1 66  ? 13.450 -41.539 -14.342 1.00 43.74  ? 47  GLY A CA  1 
ATOM   382  C C   . GLY A 1 66  ? 14.281 -40.671 -15.272 1.00 44.86  ? 47  GLY A C   1 
ATOM   383  O O   . GLY A 1 66  ? 13.750 -40.257 -16.289 1.00 54.83  ? 47  GLY A O   1 
ATOM   384  N N   . HIS A 1 67  ? 15.560 -40.448 -14.989 1.00 41.21  ? 48  HIS A N   1 
ATOM   385  C CA  . HIS A 1 67  ? 16.425 -39.584 -15.830 1.00 43.30  ? 48  HIS A CA  1 
ATOM   386  C C   . HIS A 1 67  ? 17.492 -40.447 -16.494 1.00 42.32  ? 48  HIS A C   1 
ATOM   387  O O   . HIS A 1 67  ? 17.810 -41.542 -15.971 1.00 40.07  ? 48  HIS A O   1 
ATOM   388  C CB  . HIS A 1 67  ? 17.021 -38.434 -15.003 1.00 49.79  ? 48  HIS A CB  1 
ATOM   389  C CG  . HIS A 1 67  ? 15.988 -37.507 -14.455 1.00 58.59  ? 48  HIS A CG  1 
ATOM   390  N ND1 . HIS A 1 67  ? 15.656 -37.488 -13.117 1.00 67.48  ? 48  HIS A ND1 1 
ATOM   391  C CD2 . HIS A 1 67  ? 15.192 -36.591 -15.056 1.00 65.61  ? 48  HIS A CD2 1 
ATOM   392  C CE1 . HIS A 1 67  ? 14.715 -36.584 -12.908 1.00 68.49  ? 48  HIS A CE1 1 
ATOM   393  N NE2 . HIS A 1 67  ? 14.410 -36.020 -14.085 1.00 64.21  ? 48  HIS A NE2 1 
ATOM   394  N N   . ARG A 1 68  ? 18.029 -39.972 -17.613 1.00 39.65  ? 49  ARG A N   1 
ATOM   395  C CA  . ARG A 1 68  ? 19.233 -40.566 -18.241 1.00 41.29  ? 49  ARG A CA  1 
ATOM   396  C C   . ARG A 1 68  ? 20.415 -39.978 -17.467 1.00 36.52  ? 49  ARG A C   1 
ATOM   397  O O   . ARG A 1 68  ? 20.284 -38.875 -16.975 1.00 31.52  ? 49  ARG A O   1 
ATOM   398  C CB  . ARG A 1 68  ? 19.216 -40.329 -19.754 1.00 48.70  ? 49  ARG A CB  1 
ATOM   399  C CG  . ARG A 1 68  ? 18.038 -41.010 -20.441 1.00 56.15  ? 49  ARG A CG  1 
ATOM   400  C CD  . ARG A 1 68  ? 18.207 -41.301 -21.918 1.00 62.02  ? 49  ARG A CD  1 
ATOM   401  N NE  . ARG A 1 68  ? 18.990 -42.514 -22.119 1.00 66.04  ? 49  ARG A NE  1 
ATOM   402  C CZ  . ARG A 1 68  ? 20.193 -42.575 -22.688 1.00 73.96  ? 49  ARG A CZ  1 
ATOM   403  N NH1 . ARG A 1 68  ? 20.775 -41.476 -23.160 1.00 72.12  ? 49  ARG A NH1 1 
ATOM   404  N NH2 . ARG A 1 68  ? 20.798 -43.753 -22.799 1.00 72.92  ? 49  ARG A NH2 1 
ATOM   405  N N   . VAL A 1 69  ? 21.460 -40.750 -17.240 1.00 31.15  ? 50  VAL A N   1 
ATOM   406  C CA  . VAL A 1 69  ? 22.588 -40.308 -16.389 1.00 31.47  ? 50  VAL A CA  1 
ATOM   407  C C   . VAL A 1 69  ? 23.843 -40.774 -17.103 1.00 33.16  ? 50  VAL A C   1 
ATOM   408  O O   . VAL A 1 69  ? 23.764 -41.730 -17.946 1.00 29.46  ? 50  VAL A O   1 
ATOM   409  C CB  . VAL A 1 69  ? 22.520 -40.878 -14.958 1.00 32.00  ? 50  VAL A CB  1 
ATOM   410  C CG1 . VAL A 1 69  ? 21.354 -40.300 -14.164 1.00 31.20  ? 50  VAL A CG1 1 
ATOM   411  C CG2 . VAL A 1 69  ? 22.506 -42.411 -14.953 1.00 32.52  ? 50  VAL A CG2 1 
ATOM   412  N N   . ALA A 1 70  ? 24.962 -40.171 -16.726 1.00 29.53  ? 51  ALA A N   1 
ATOM   413  C CA  . ALA A 1 70  ? 26.292 -40.689 -17.088 1.00 28.58  ? 51  ALA A CA  1 
ATOM   414  C C   . ALA A 1 70  ? 26.768 -41.573 -15.941 1.00 28.04  ? 51  ALA A C   1 
ATOM   415  O O   . ALA A 1 70  ? 26.667 -41.117 -14.748 1.00 30.71  ? 51  ALA A O   1 
ATOM   416  C CB  . ALA A 1 70  ? 27.233 -39.538 -17.356 1.00 29.01  ? 51  ALA A CB  1 
ATOM   417  N N   . VAL A 1 71  ? 27.287 -42.750 -16.292 1.00 28.12  ? 52  VAL A N   1 
ATOM   418  C CA  . VAL A 1 71  ? 27.923 -43.727 -15.374 1.00 29.03  ? 52  VAL A CA  1 
ATOM   419  C C   . VAL A 1 71  ? 29.367 -43.877 -15.827 1.00 32.13  ? 52  VAL A C   1 
ATOM   420  O O   . VAL A 1 71  ? 29.581 -44.356 -16.969 1.00 29.58  ? 52  VAL A O   1 
ATOM   421  C CB  . VAL A 1 71  ? 27.207 -45.089 -15.372 1.00 32.20  ? 52  VAL A CB  1 
ATOM   422  C CG1 . VAL A 1 71  ? 27.801 -46.012 -14.321 1.00 32.12  ? 52  VAL A CG1 1 
ATOM   423  C CG2 . VAL A 1 71  ? 25.705 -44.946 -15.161 1.00 32.50  ? 52  VAL A CG2 1 
ATOM   424  N N   . LYS A 1 72  ? 30.303 -43.405 -15.000 1.00 30.80  ? 53  LYS A N   1 
ATOM   425  C CA  . LYS A 1 72  ? 31.749 -43.530 -15.289 1.00 30.14  ? 53  LYS A CA  1 
ATOM   426  C C   . LYS A 1 72  ? 32.327 -44.680 -14.467 1.00 26.50  ? 53  LYS A C   1 
ATOM   427  O O   . LYS A 1 72  ? 32.219 -44.651 -13.222 1.00 28.42  ? 53  LYS A O   1 
ATOM   428  C CB  . LYS A 1 72  ? 32.499 -42.233 -14.991 1.00 30.37  ? 53  LYS A CB  1 
ATOM   429  C CG  . LYS A 1 72  ? 33.988 -42.321 -15.305 1.00 31.44  ? 53  LYS A CG  1 
ATOM   430  C CD  . LYS A 1 72  ? 34.708 -41.005 -15.421 1.00 33.71  ? 53  LYS A CD  1 
ATOM   431  C CE  . LYS A 1 72  ? 34.756 -40.245 -14.117 1.00 39.30  ? 53  LYS A CE  1 
ATOM   432  N NZ  . LYS A 1 72  ? 35.343 -38.897 -14.302 1.00 41.44  ? 53  LYS A NZ  1 
ATOM   433  N N   . LYS A 1 73  ? 32.894 -45.670 -15.149 1.00 28.22  ? 54  LYS A N   1 
ATOM   434  C CA  . LYS A 1 73  ? 33.744 -46.711 -14.519 1.00 30.39  ? 54  LYS A CA  1 
ATOM   435  C C   . LYS A 1 73  ? 35.203 -46.242 -14.560 1.00 31.89  ? 54  LYS A C   1 
ATOM   436  O O   . LYS A 1 73  ? 35.739 -46.055 -15.655 1.00 29.63  ? 54  LYS A O   1 
ATOM   437  C CB  . LYS A 1 73  ? 33.592 -48.055 -15.217 1.00 30.89  ? 54  LYS A CB  1 
ATOM   438  C CG  . LYS A 1 73  ? 34.363 -49.177 -14.545 1.00 31.19  ? 54  LYS A CG  1 
ATOM   439  C CD  . LYS A 1 73  ? 34.500 -50.446 -15.363 1.00 31.99  ? 54  LYS A CD  1 
ATOM   440  C CE  . LYS A 1 73  ? 35.088 -51.563 -14.520 1.00 35.61  ? 54  LYS A CE  1 
ATOM   441  N NZ  . LYS A 1 73  ? 35.471 -52.727 -15.345 1.00 39.46  ? 54  LYS A NZ  1 
ATOM   442  N N   . LEU A 1 74  ? 35.827 -46.043 -13.398 1.00 34.35  ? 55  LEU A N   1 
ATOM   443  C CA  . LEU A 1 74  ? 37.264 -45.695 -13.360 1.00 35.67  ? 55  LEU A CA  1 
ATOM   444  C C   . LEU A 1 74  ? 38.078 -46.916 -13.799 1.00 38.52  ? 55  LEU A C   1 
ATOM   445  O O   . LEU A 1 74  ? 37.730 -48.060 -13.405 1.00 34.59  ? 55  LEU A O   1 
ATOM   446  C CB  . LEU A 1 74  ? 37.618 -45.172 -11.968 1.00 32.04  ? 55  LEU A CB  1 
ATOM   447  C CG  . LEU A 1 74  ? 36.977 -43.832 -11.675 1.00 31.97  ? 55  LEU A CG  1 
ATOM   448  C CD1 . LEU A 1 74  ? 37.397 -43.304 -10.321 1.00 34.01  ? 55  LEU A CD1 1 
ATOM   449  C CD2 . LEU A 1 74  ? 37.321 -42.823 -12.759 1.00 34.38  ? 55  LEU A CD2 1 
ATOM   450  N N   . SER A 1 75  ? 39.105 -46.677 -14.621 1.00 45.84  ? 56  SER A N   1 
ATOM   451  C CA  . SER A 1 75  ? 40.061 -47.726 -15.080 1.00 55.44  ? 56  SER A CA  1 
ATOM   452  C C   . SER A 1 75  ? 41.171 -47.908 -14.026 1.00 47.26  ? 56  SER A C   1 
ATOM   453  O O   . SER A 1 75  ? 41.947 -46.938 -13.831 1.00 45.45  ? 56  SER A O   1 
ATOM   454  C CB  . SER A 1 75  ? 40.610 -47.401 -16.457 1.00 61.84  ? 56  SER A CB  1 
ATOM   455  O OG  . SER A 1 75  ? 41.337 -46.181 -16.437 1.00 74.22  ? 56  SER A OG  1 
ATOM   456  N N   . ARG A 1 76  ? 41.179 -49.060 -13.332 1.00 40.94  ? 57  ARG A N   1 
ATOM   457  C CA  . ARG A 1 76  ? 42.219 -49.464 -12.339 1.00 51.54  ? 57  ARG A CA  1 
ATOM   458  C C   . ARG A 1 76  ? 42.607 -48.256 -11.467 1.00 46.32  ? 57  ARG A C   1 
ATOM   459  O O   . ARG A 1 76  ? 43.754 -47.796 -11.466 1.00 38.64  ? 57  ARG A O   1 
ATOM   460  C CB  . ARG A 1 76  ? 43.426 -50.075 -13.065 1.00 59.52  ? 57  ARG A CB  1 
ATOM   461  C CG  . ARG A 1 76  ? 43.203 -51.478 -13.626 1.00 64.28  ? 57  ARG A CG  1 
ATOM   462  C CD  . ARG A 1 76  ? 44.413 -52.059 -14.363 1.00 66.86  ? 57  ARG A CD  1 
ATOM   463  N NE  . ARG A 1 76  ? 44.754 -51.318 -15.587 1.00 68.16  ? 57  ARG A NE  1 
ATOM   464  C CZ  . ARG A 1 76  ? 45.912 -50.695 -15.838 1.00 73.26  ? 57  ARG A CZ  1 
ATOM   465  N NH1 . ARG A 1 76  ? 46.919 -50.712 -14.972 1.00 78.09  ? 57  ARG A NH1 1 
ATOM   466  N NH2 . ARG A 1 76  ? 46.061 -50.055 -16.983 1.00 76.42  ? 57  ARG A NH2 1 
ATOM   467  N N   . PRO A 1 77  ? 41.642 -47.683 -10.706 1.00 39.47  ? 58  PRO A N   1 
ATOM   468  C CA  . PRO A 1 77  ? 41.885 -46.455 -9.947  1.00 35.75  ? 58  PRO A CA  1 
ATOM   469  C C   . PRO A 1 77  ? 42.970 -46.553 -8.861  1.00 31.41  ? 58  PRO A C   1 
ATOM   470  O O   . PRO A 1 77  ? 43.393 -45.516 -8.433  1.00 33.82  ? 58  PRO A O   1 
ATOM   471  C CB  . PRO A 1 77  ? 40.524 -46.180 -9.283  1.00 36.85  ? 58  PRO A CB  1 
ATOM   472  C CG  . PRO A 1 77  ? 39.852 -47.545 -9.233  1.00 38.75  ? 58  PRO A CG  1 
ATOM   473  C CD  . PRO A 1 77  ? 40.282 -48.218 -10.513 1.00 38.60  ? 58  PRO A CD  1 
ATOM   474  N N   . PHE A 1 78  ? 43.373 -47.759 -8.450  1.00 27.43  ? 59  PHE A N   1 
ATOM   475  C CA  . PHE A 1 78  ? 44.315 -48.001 -7.331  1.00 30.95  ? 59  PHE A CA  1 
ATOM   476  C C   . PHE A 1 78  ? 45.591 -48.712 -7.816  1.00 33.12  ? 59  PHE A C   1 
ATOM   477  O O   . PHE A 1 78  ? 46.235 -49.449 -7.019  1.00 33.15  ? 59  PHE A O   1 
ATOM   478  C CB  . PHE A 1 78  ? 43.577 -48.780 -6.247  1.00 29.63  ? 59  PHE A CB  1 
ATOM   479  C CG  . PHE A 1 78  ? 42.256 -48.149 -5.885  1.00 30.56  ? 59  PHE A CG  1 
ATOM   480  C CD1 . PHE A 1 78  ? 42.200 -46.849 -5.408  1.00 30.49  ? 59  PHE A CD1 1 
ATOM   481  C CD2 . PHE A 1 78  ? 41.068 -48.840 -6.047  1.00 33.25  ? 59  PHE A CD2 1 
ATOM   482  C CE1 . PHE A 1 78  ? 40.988 -46.269 -5.077  1.00 32.21  ? 59  PHE A CE1 1 
ATOM   483  C CE2 . PHE A 1 78  ? 39.856 -48.261 -5.705  1.00 33.47  ? 59  PHE A CE2 1 
ATOM   484  C CZ  . PHE A 1 78  ? 39.817 -46.976 -5.228  1.00 32.48  ? 59  PHE A CZ  1 
ATOM   485  N N   . GLN A 1 79  ? 45.993 -48.471 -9.063  1.00 33.90  ? 60  GLN A N   1 
ATOM   486  C CA  . GLN A 1 79  ? 47.207 -49.122 -9.643  1.00 34.64  ? 60  GLN A CA  1 
ATOM   487  C C   . GLN A 1 79  ? 48.463 -48.429 -9.109  1.00 32.57  ? 60  GLN A C   1 
ATOM   488  O O   . GLN A 1 79  ? 49.505 -49.060 -9.090  1.00 32.75  ? 60  GLN A O   1 
ATOM   489  C CB  . GLN A 1 79  ? 47.167 -49.084 -11.172 1.00 39.23  ? 60  GLN A CB  1 
ATOM   490  C CG  . GLN A 1 79  ? 47.109 -47.686 -11.761 1.00 44.47  ? 60  GLN A CG  1 
ATOM   491  C CD  . GLN A 1 79  ? 47.342 -47.638 -13.257 1.00 52.14  ? 60  GLN A CD  1 
ATOM   492  O OE1 . GLN A 1 79  ? 48.053 -48.443 -13.846 1.00 63.12  ? 60  GLN A OE1 1 
ATOM   493  N NE2 . GLN A 1 79  ? 46.729 -46.661 -13.899 1.00 62.68  ? 60  GLN A NE2 1 
ATOM   494  N N   . SER A 1 80  ? 48.343 -47.166 -8.698  1.00 28.34  ? 61  SER A N   1 
ATOM   495  C CA  . SER A 1 80  ? 49.472 -46.292 -8.311  1.00 27.66  ? 61  SER A CA  1 
ATOM   496  C C   . SER A 1 80  ? 49.003 -45.269 -7.276  1.00 26.14  ? 61  SER A C   1 
ATOM   497  O O   . SER A 1 80  ? 47.790 -45.034 -7.163  1.00 25.23  ? 61  SER A O   1 
ATOM   498  C CB  . SER A 1 80  ? 50.066 -45.593 -9.524  1.00 27.18  ? 61  SER A CB  1 
ATOM   499  O OG  . SER A 1 80  ? 49.203 -44.563 -9.987  1.00 25.82  ? 61  SER A OG  1 
ATOM   500  N N   . ILE A 1 81  ? 49.940 -44.623 -6.610  1.00 25.82  ? 62  ILE A N   1 
ATOM   501  C CA  . ILE A 1 81  ? 49.626 -43.467 -5.722  1.00 25.82  ? 62  ILE A CA  1 
ATOM   502  C C   . ILE A 1 81  ? 48.912 -42.391 -6.541  1.00 28.44  ? 62  ILE A C   1 
ATOM   503  O O   . ILE A 1 81  ? 47.831 -41.885 -6.082  1.00 26.84  ? 62  ILE A O   1 
ATOM   504  C CB  . ILE A 1 81  ? 50.910 -42.981 -5.021  1.00 25.95  ? 62  ILE A CB  1 
ATOM   505  C CG1 . ILE A 1 81  ? 51.340 -43.998 -3.952  1.00 25.60  ? 62  ILE A CG1 1 
ATOM   506  C CG2 . ILE A 1 81  ? 50.733 -41.592 -4.432  1.00 26.30  ? 62  ILE A CG2 1 
ATOM   507  C CD1 . ILE A 1 81  ? 52.734 -43.766 -3.391  1.00 26.99  ? 62  ILE A CD1 1 
ATOM   508  N N   . ILE A 1 82  ? 49.471 -42.017 -7.695  1.00 29.16  ? 63  ILE A N   1 
ATOM   509  C CA  . ILE A 1 82  ? 48.907 -40.917 -8.536  1.00 27.13  ? 63  ILE A CA  1 
ATOM   510  C C   . ILE A 1 82  ? 47.443 -41.226 -8.862  1.00 25.48  ? 63  ILE A C   1 
ATOM   511  O O   . ILE A 1 82  ? 46.601 -40.344 -8.669  1.00 23.40  ? 63  ILE A O   1 
ATOM   512  C CB  . ILE A 1 82  ? 49.746 -40.688 -9.800  1.00 31.18  ? 63  ILE A CB  1 
ATOM   513  C CG1 . ILE A 1 82  ? 51.121 -40.104 -9.447  1.00 32.27  ? 63  ILE A CG1 1 
ATOM   514  C CG2 . ILE A 1 82  ? 48.987 -39.816 -10.807 1.00 31.23  ? 63  ILE A CG2 1 
ATOM   515  C CD1 . ILE A 1 82  ? 52.144 -40.162 -10.587 1.00 32.60  ? 63  ILE A CD1 1 
ATOM   516  N N   . HIS A 1 83  ? 47.129 -42.433 -9.297  1.00 25.23  ? 64  HIS A N   1 
ATOM   517  C CA  . HIS A 1 83  ? 45.737 -42.832 -9.638  1.00 27.70  ? 64  HIS A CA  1 
ATOM   518  C C   . HIS A 1 83  ? 44.872 -42.895 -8.362  1.00 26.49  ? 64  HIS A C   1 
ATOM   519  O O   . HIS A 1 83  ? 43.731 -42.401 -8.380  1.00 23.29  ? 64  HIS A O   1 
ATOM   520  C CB  . HIS A 1 83  ? 45.725 -44.161 -10.419 1.00 32.15  ? 64  HIS A CB  1 
ATOM   521  C CG  . HIS A 1 83  ? 46.087 -44.021 -11.864 1.00 35.60  ? 64  HIS A CG  1 
ATOM   522  N ND1 . HIS A 1 83  ? 47.338 -43.604 -12.287 1.00 38.77  ? 64  HIS A ND1 1 
ATOM   523  C CD2 . HIS A 1 83  ? 45.368 -44.207 -12.987 1.00 42.35  ? 64  HIS A CD2 1 
ATOM   524  C CE1 . HIS A 1 83  ? 47.378 -43.577 -13.598 1.00 37.28  ? 64  HIS A CE1 1 
ATOM   525  N NE2 . HIS A 1 83  ? 46.199 -43.941 -14.048 1.00 40.86  ? 64  HIS A NE2 1 
ATOM   526  N N   . ALA A 1 84  ? 45.359 -43.545 -7.307  1.00 23.31  ? 65  ALA A N   1 
ATOM   527  C CA  . ALA A 1 84  ? 44.573 -43.712 -6.068  1.00 24.53  ? 65  ALA A CA  1 
ATOM   528  C C   . ALA A 1 84  ? 44.213 -42.323 -5.521  1.00 22.52  ? 65  ALA A C   1 
ATOM   529  O O   . ALA A 1 84  ? 43.073 -42.101 -5.185  1.00 22.48  ? 65  ALA A O   1 
ATOM   530  C CB  . ALA A 1 84  ? 45.318 -44.553 -5.070  1.00 22.77  ? 65  ALA A CB  1 
ATOM   531  N N   . LYS A 1 85  ? 45.180 -41.425 -5.434  1.00 23.17  ? 66  LYS A N   1 
ATOM   532  C CA  . LYS A 1 85  ? 44.942 -40.074 -4.880  1.00 26.23  ? 66  LYS A CA  1 
ATOM   533  C C   . LYS A 1 85  ? 43.993 -39.312 -5.806  1.00 25.63  ? 66  LYS A C   1 
ATOM   534  O O   . LYS A 1 85  ? 43.116 -38.585 -5.296  1.00 21.70  ? 66  LYS A O   1 
ATOM   535  C CB  . LYS A 1 85  ? 46.260 -39.337 -4.699  1.00 25.98  ? 66  LYS A CB  1 
ATOM   536  C CG  . LYS A 1 85  ? 46.154 -38.026 -3.957  1.00 28.21  ? 66  LYS A CG  1 
ATOM   537  C CD  . LYS A 1 85  ? 47.516 -37.389 -3.777  1.00 29.56  ? 66  LYS A CD  1 
ATOM   538  C CE  . LYS A 1 85  ? 47.442 -36.039 -3.114  1.00 30.13  ? 66  LYS A CE  1 
ATOM   539  N NZ  . LYS A 1 85  ? 48.792 -35.454 -2.976  1.00 33.62  ? 66  LYS A NZ  1 
ATOM   540  N N   . ARG A 1 86  ? 44.167 -39.481 -7.112  1.00 26.35  ? 67  ARG A N   1 
ATOM   541  C CA  . ARG A 1 86  ? 43.338 -38.787 -8.123  1.00 29.99  ? 67  ARG A CA  1 
ATOM   542  C C   . ARG A 1 86  ? 41.889 -39.243 -7.943  1.00 27.25  ? 67  ARG A C   1 
ATOM   543  O O   . ARG A 1 86  ? 40.985 -38.411 -8.036  1.00 24.35  ? 67  ARG A O   1 
ATOM   544  C CB  . ARG A 1 86  ? 43.784 -39.098 -9.550  1.00 36.43  ? 67  ARG A CB  1 
ATOM   545  C CG  . ARG A 1 86  ? 42.886 -38.447 -10.590 1.00 47.91  ? 67  ARG A CG  1 
ATOM   546  C CD  . ARG A 1 86  ? 43.362 -38.656 -12.005 1.00 59.82  ? 67  ARG A CD  1 
ATOM   547  N NE  . ARG A 1 86  ? 42.782 -37.686 -12.939 1.00 75.13  ? 67  ARG A NE  1 
ATOM   548  C CZ  . ARG A 1 86  ? 41.603 -37.820 -13.549 1.00 77.96  ? 67  ARG A CZ  1 
ATOM   549  N NH1 . ARG A 1 86  ? 40.840 -38.879 -13.320 1.00 81.82  ? 67  ARG A NH1 1 
ATOM   550  N NH2 . ARG A 1 86  ? 41.193 -36.887 -14.391 1.00 73.84  ? 67  ARG A NH2 1 
ATOM   551  N N   . THR A 1 87  ? 41.690 -40.536 -7.706  1.00 25.75  ? 68  THR A N   1 
ATOM   552  C CA  . THR A 1 87  ? 40.345 -41.134 -7.494  1.00 24.61  ? 68  THR A CA  1 
ATOM   553  C C   . THR A 1 87  ? 39.750 -40.508 -6.231  1.00 25.52  ? 68  THR A C   1 
ATOM   554  O O   . THR A 1 87  ? 38.583 -40.110 -6.230  1.00 22.19  ? 68  THR A O   1 
ATOM   555  C CB  . THR A 1 87  ? 40.454 -42.654 -7.397  1.00 23.87  ? 68  THR A CB  1 
ATOM   556  O OG1 . THR A 1 87  ? 41.044 -43.115 -8.620  1.00 25.64  ? 68  THR A OG1 1 
ATOM   557  C CG2 . THR A 1 87  ? 39.117 -43.281 -7.117  1.00 24.19  ? 68  THR A CG2 1 
ATOM   558  N N   . TYR A 1 88  ? 40.539 -40.446 -5.163  1.00 24.20  ? 69  TYR A N   1 
ATOM   559  C CA  . TYR A 1 88  ? 40.083 -39.873 -3.881  1.00 22.21  ? 69  TYR A CA  1 
ATOM   560  C C   . TYR A 1 88  ? 39.713 -38.401 -4.110  1.00 23.63  ? 69  TYR A C   1 
ATOM   561  O O   . TYR A 1 88  ? 38.625 -37.959 -3.638  1.00 21.24  ? 69  TYR A O   1 
ATOM   562  C CB  . TYR A 1 88  ? 41.164 -40.042 -2.811  1.00 20.75  ? 69  TYR A CB  1 
ATOM   563  C CG  . TYR A 1 88  ? 40.795 -39.404 -1.502  1.00 20.05  ? 69  TYR A CG  1 
ATOM   564  C CD1 . TYR A 1 88  ? 39.881 -40.004 -0.660  1.00 21.60  ? 69  TYR A CD1 1 
ATOM   565  C CD2 . TYR A 1 88  ? 41.343 -38.202 -1.126  1.00 20.27  ? 69  TYR A CD2 1 
ATOM   566  C CE1 . TYR A 1 88  ? 39.530 -39.426 0.540   1.00 23.02  ? 69  TYR A CE1 1 
ATOM   567  C CE2 . TYR A 1 88  ? 41.020 -37.614 0.076   1.00 21.46  ? 69  TYR A CE2 1 
ATOM   568  C CZ  . TYR A 1 88  ? 40.092 -38.213 0.896   1.00 22.69  ? 69  TYR A CZ  1 
ATOM   569  O OH  . TYR A 1 88  ? 39.731 -37.625 2.065   1.00 23.96  ? 69  TYR A OH  1 
ATOM   570  N N   . ARG A 1 89  ? 40.590 -37.665 -4.802  1.00 22.99  ? 70  ARG A N   1 
ATOM   571  C CA  . ARG A 1 89  ? 40.372 -36.228 -5.125  1.00 24.50  ? 70  ARG A CA  1 
ATOM   572  C C   . ARG A 1 89  ? 39.017 -36.040 -5.814  1.00 24.64  ? 70  ARG A C   1 
ATOM   573  O O   . ARG A 1 89  ? 38.236 -35.113 -5.428  1.00 23.77  ? 70  ARG A O   1 
ATOM   574  C CB  . ARG A 1 89  ? 41.486 -35.699 -6.027  1.00 24.19  ? 70  ARG A CB  1 
ATOM   575  C CG  . ARG A 1 89  ? 41.429 -34.200 -6.255  1.00 24.50  ? 70  ARG A CG  1 
ATOM   576  C CD  . ARG A 1 89  ? 42.498 -33.758 -7.245  1.00 24.59  ? 70  ARG A CD  1 
ATOM   577  N NE  . ARG A 1 89  ? 43.806 -33.885 -6.628  1.00 25.23  ? 70  ARG A NE  1 
ATOM   578  C CZ  . ARG A 1 89  ? 44.788 -34.689 -7.005  1.00 24.90  ? 70  ARG A CZ  1 
ATOM   579  N NH1 . ARG A 1 89  ? 44.677 -35.432 -8.083  1.00 28.27  ? 70  ARG A NH1 1 
ATOM   580  N NH2 . ARG A 1 89  ? 45.904 -34.733 -6.297  1.00 26.54  ? 70  ARG A NH2 1 
ATOM   581  N N   . GLU A 1 90  ? 38.730 -36.875 -6.800  1.00 23.88  ? 71  GLU A N   1 
ATOM   582  C CA  . GLU A 1 90  ? 37.516 -36.670 -7.622  1.00 27.47  ? 71  GLU A CA  1 
ATOM   583  C C   . GLU A 1 90  ? 36.285 -36.918 -6.744  1.00 26.59  ? 71  GLU A C   1 
ATOM   584  O O   . GLU A 1 90  ? 35.311 -36.141 -6.779  1.00 26.53  ? 71  GLU A O   1 
ATOM   585  C CB  . GLU A 1 90  ? 37.506 -37.574 -8.848  1.00 25.73  ? 71  GLU A CB  1 
ATOM   586  C CG  . GLU A 1 90  ? 36.258 -37.372 -9.679  1.00 24.68  ? 71  GLU A CG  1 
ATOM   587  C CD  . GLU A 1 90  ? 36.261 -38.072 -11.021 1.00 26.12  ? 71  GLU A CD  1 
ATOM   588  O OE1 . GLU A 1 90  ? 37.015 -39.044 -11.166 1.00 29.24  ? 71  GLU A OE1 1 
ATOM   589  O OE2 . GLU A 1 90  ? 35.467 -37.680 -11.894 1.00 27.94  ? 71  GLU A OE2 1 
ATOM   590  N N   . LEU A 1 91  ? 36.337 -37.973 -5.964  1.00 25.26  ? 72  LEU A N   1 
ATOM   591  C CA  . LEU A 1 91  ? 35.190 -38.376 -5.134  1.00 24.34  ? 72  LEU A CA  1 
ATOM   592  C C   . LEU A 1 91  ? 34.952 -37.291 -4.090  1.00 23.97  ? 72  LEU A C   1 
ATOM   593  O O   . LEU A 1 91  ? 33.783 -36.919 -3.898  1.00 22.76  ? 72  LEU A O   1 
ATOM   594  C CB  . LEU A 1 91  ? 35.476 -39.746 -4.540  1.00 24.86  ? 72  LEU A CB  1 
ATOM   595  C CG  . LEU A 1 91  ? 34.295 -40.440 -3.880  1.00 28.67  ? 72  LEU A CG  1 
ATOM   596  C CD1 . LEU A 1 91  ? 32.999 -40.285 -4.694  1.00 32.82  ? 72  LEU A CD1 1 
ATOM   597  C CD2 . LEU A 1 91  ? 34.603 -41.904 -3.668  1.00 26.81  ? 72  LEU A CD2 1 
ATOM   598  N N   . ARG A 1 92  ? 36.010 -36.800 -3.442  1.00 22.70  ? 73  ARG A N   1 
ATOM   599  C CA  . ARG A 1 92  ? 35.861 -35.734 -2.416  1.00 22.33  ? 73  ARG A CA  1 
ATOM   600  C C   . ARG A 1 92  ? 35.220 -34.500 -3.080  1.00 22.59  ? 73  ARG A C   1 
ATOM   601  O O   . ARG A 1 92  ? 34.282 -33.911 -2.521  1.00 21.48  ? 73  ARG A O   1 
ATOM   602  C CB  . ARG A 1 92  ? 37.223 -35.434 -1.785  1.00 23.03  ? 73  ARG A CB  1 
ATOM   603  C CG  . ARG A 1 92  ? 37.642 -36.417 -0.692  1.00 23.32  ? 73  ARG A CG  1 
ATOM   604  C CD  . ARG A 1 92  ? 36.846 -36.290 0.603   1.00 22.03  ? 73  ARG A CD  1 
ATOM   605  N NE  . ARG A 1 92  ? 36.728 -34.919 1.071   1.00 22.82  ? 73  ARG A NE  1 
ATOM   606  C CZ  . ARG A 1 92  ? 37.676 -34.227 1.684   1.00 25.79  ? 73  ARG A CZ  1 
ATOM   607  N NH1 . ARG A 1 92  ? 38.851 -34.778 1.945   1.00 27.45  ? 73  ARG A NH1 1 
ATOM   608  N NH2 . ARG A 1 92  ? 37.455 -32.965 2.035   1.00 26.51  ? 73  ARG A NH2 1 
ATOM   609  N N   . LEU A 1 93  ? 35.685 -34.130 -4.271  1.00 23.86  ? 74  LEU A N   1 
ATOM   610  C CA  . LEU A 1 93  ? 35.185 -32.928 -4.976  1.00 24.03  ? 74  LEU A CA  1 
ATOM   611  C C   . LEU A 1 93  ? 33.715 -33.095 -5.370  1.00 22.12  ? 74  LEU A C   1 
ATOM   612  O O   . LEU A 1 93  ? 32.931 -32.189 -5.080  1.00 19.52  ? 74  LEU A O   1 
ATOM   613  C CB  . LEU A 1 93  ? 36.038 -32.652 -6.201  1.00 25.83  ? 74  LEU A CB  1 
ATOM   614  C CG  . LEU A 1 93  ? 35.599 -31.415 -6.952  1.00 31.00  ? 74  LEU A CG  1 
ATOM   615  C CD1 . LEU A 1 93  ? 35.929 -30.170 -6.141  1.00 33.30  ? 74  LEU A CD1 1 
ATOM   616  C CD2 . LEU A 1 93  ? 36.254 -31.380 -8.315  1.00 33.50  ? 74  LEU A CD2 1 
ATOM   617  N N   . LEU A 1 94  ? 33.344 -34.191 -6.019  1.00 21.26  ? 75  LEU A N   1 
ATOM   618  C CA  . LEU A 1 94  ? 31.941 -34.390 -6.473  1.00 22.92  ? 75  LEU A CA  1 
ATOM   619  C C   . LEU A 1 94  ? 30.986 -34.511 -5.287  1.00 23.63  ? 75  LEU A C   1 
ATOM   620  O O   . LEU A 1 94  ? 29.826 -34.091 -5.400  1.00 24.57  ? 75  LEU A O   1 
ATOM   621  C CB  . LEU A 1 94  ? 31.853 -35.630 -7.362  1.00 23.74  ? 75  LEU A CB  1 
ATOM   622  C CG  . LEU A 1 94  ? 32.659 -35.515 -8.651  1.00 25.76  ? 75  LEU A CG  1 
ATOM   623  C CD1 . LEU A 1 94  ? 32.631 -36.826 -9.398  1.00 26.40  ? 75  LEU A CD1 1 
ATOM   624  C CD2 . LEU A 1 94  ? 32.136 -34.369 -9.522  1.00 27.38  ? 75  LEU A CD2 1 
ATOM   625  N N   . LYS A 1 95  ? 31.435 -35.083 -4.186  1.00 23.09  ? 76  LYS A N   1 
ATOM   626  C CA  . LYS A 1 95  ? 30.578 -35.231 -2.997  1.00 25.16  ? 76  LYS A CA  1 
ATOM   627  C C   . LYS A 1 95  ? 30.364 -33.861 -2.364  1.00 23.86  ? 76  LYS A C   1 
ATOM   628  O O   . LYS A 1 95  ? 29.359 -33.665 -1.714  1.00 27.39  ? 76  LYS A O   1 
ATOM   629  C CB  . LYS A 1 95  ? 31.210 -36.175 -1.974  1.00 25.69  ? 76  LYS A CB  1 
ATOM   630  C CG  . LYS A 1 95  ? 31.163 -37.641 -2.356  1.00 28.75  ? 76  LYS A CG  1 
ATOM   631  C CD  . LYS A 1 95  ? 31.640 -38.568 -1.251  1.00 31.42  ? 76  LYS A CD  1 
ATOM   632  C CE  . LYS A 1 95  ? 30.834 -38.481 0.037   1.00 31.21  ? 76  LYS A CE  1 
ATOM   633  N NZ  . LYS A 1 95  ? 31.441 -39.339 1.098   1.00 32.77  ? 76  LYS A NZ  1 
ATOM   634  N N   . HIS A 1 96  ? 31.306 -32.953 -2.489  1.00 25.96  ? 77  HIS A N   1 
ATOM   635  C CA  . HIS A 1 96  ? 31.153 -31.615 -1.873  1.00 26.73  ? 77  HIS A CA  1 
ATOM   636  C C   . HIS A 1 96  ? 30.137 -30.746 -2.640  1.00 28.05  ? 77  HIS A C   1 
ATOM   637  O O   . HIS A 1 96  ? 29.402 -29.981 -1.992  1.00 26.09  ? 77  HIS A O   1 
ATOM   638  C CB  . HIS A 1 96  ? 32.498 -30.923 -1.804  1.00 26.62  ? 77  HIS A CB  1 
ATOM   639  C CG  . HIS A 1 96  ? 32.447 -29.712 -0.959  1.00 26.82  ? 77  HIS A CG  1 
ATOM   640  N ND1 . HIS A 1 96  ? 32.361 -29.803 0.398   1.00 26.88  ? 77  HIS A ND1 1 
ATOM   641  C CD2 . HIS A 1 96  ? 32.466 -28.394 -1.268  1.00 29.00  ? 77  HIS A CD2 1 
ATOM   642  C CE1 . HIS A 1 96  ? 32.337 -28.574 0.922   1.00 28.53  ? 77  HIS A CE1 1 
ATOM   643  N NE2 . HIS A 1 96  ? 32.433 -27.690 -0.083  1.00 28.81  ? 77  HIS A NE2 1 
ATOM   644  N N   . MET A 1 97  ? 30.119 -30.825 -3.970  1.00 28.39  ? 78  MET A N   1 
ATOM   645  C CA  . MET A 1 97  ? 29.493 -29.766 -4.815  1.00 30.82  ? 78  MET A CA  1 
ATOM   646  C C   . MET A 1 97  ? 27.984 -29.988 -4.993  1.00 26.93  ? 78  MET A C   1 
ATOM   647  O O   . MET A 1 97  ? 27.592 -30.980 -5.603  1.00 23.79  ? 78  MET A O   1 
ATOM   648  C CB  . MET A 1 97  ? 30.229 -29.662 -6.153  1.00 32.98  ? 78  MET A CB  1 
ATOM   649  C CG  . MET A 1 97  ? 31.451 -28.823 -5.936  1.00 33.30  ? 78  MET A CG  1 
ATOM   650  S SD  . MET A 1 97  ? 32.445 -28.595 -7.347  1.00 44.86  ? 78  MET A SD  1 
ATOM   651  C CE  . MET A 1 97  ? 32.447 -30.177 -8.178  1.00 43.58  ? 78  MET A CE  1 
ATOM   652  N N   . LYS A 1 98  ? 27.201 -29.075 -4.420  1.00 26.68  ? 79  LYS A N   1 
ATOM   653  C CA  . LYS A 1 98  ? 25.726 -29.136 -4.339  1.00 29.47  ? 79  LYS A CA  1 
ATOM   654  C C   . LYS A 1 98  ? 25.154 -27.775 -4.765  1.00 26.30  ? 79  LYS A C   1 
ATOM   655  O O   . LYS A 1 98  ? 24.869 -26.935 -3.914  1.00 25.64  ? 79  LYS A O   1 
ATOM   656  C CB  . LYS A 1 98  ? 25.327 -29.580 -2.929  1.00 33.94  ? 79  LYS A CB  1 
ATOM   657  C CG  . LYS A 1 98  ? 25.759 -31.004 -2.595  1.00 38.77  ? 79  LYS A CG  1 
ATOM   658  C CD  . LYS A 1 98  ? 25.410 -31.477 -1.213  1.00 43.06  ? 79  LYS A CD  1 
ATOM   659  C CE  . LYS A 1 98  ? 25.924 -32.886 -0.980  1.00 50.35  ? 79  LYS A CE  1 
ATOM   660  N NZ  . LYS A 1 98  ? 26.099 -33.199 0.462   1.00 55.80  ? 79  LYS A NZ  1 
ATOM   661  N N   . HIS A 1 99  ? 24.990 -27.604 -6.068  1.00 24.77  ? 80  HIS A N   1 
ATOM   662  C CA  . HIS A 1 99  ? 24.575 -26.335 -6.728  1.00 26.08  ? 80  HIS A CA  1 
ATOM   663  C C   . HIS A 1 99  ? 23.932 -26.682 -8.074  1.00 23.97  ? 80  HIS A C   1 
ATOM   664  O O   . HIS A 1 99  ? 24.483 -27.539 -8.777  1.00 23.00  ? 80  HIS A O   1 
ATOM   665  C CB  . HIS A 1 99  ? 25.792 -25.395 -6.784  1.00 24.22  ? 80  HIS A CB  1 
ATOM   666  C CG  . HIS A 1 99  ? 25.479 -24.018 -7.230  1.00 24.77  ? 80  HIS A CG  1 
ATOM   667  N ND1 . HIS A 1 99  ? 25.255 -23.704 -8.563  1.00 24.45  ? 80  HIS A ND1 1 
ATOM   668  C CD2 . HIS A 1 99  ? 25.389 -22.864 -6.526  1.00 24.68  ? 80  HIS A CD2 1 
ATOM   669  C CE1 . HIS A 1 99  ? 25.032 -22.402 -8.649  1.00 26.88  ? 80  HIS A CE1 1 
ATOM   670  N NE2 . HIS A 1 99  ? 25.126 -21.859 -7.412  1.00 23.88  ? 80  HIS A NE2 1 
ATOM   671  N N   . GLU A 1 100 ? 22.814 -26.034 -8.394  1.00 27.03  ? 81  GLU A N   1 
ATOM   672  C CA  . GLU A 1 100 ? 22.041 -26.168 -9.660  1.00 30.52  ? 81  GLU A CA  1 
ATOM   673  C C   . GLU A 1 100 ? 22.933 -25.953 -10.892 1.00 27.14  ? 81  GLU A C   1 
ATOM   674  O O   . GLU A 1 100 ? 22.620 -26.548 -11.903 1.00 28.03  ? 81  GLU A O   1 
ATOM   675  C CB  . GLU A 1 100 ? 20.913 -25.136 -9.742  1.00 35.21  ? 81  GLU A CB  1 
ATOM   676  C CG  . GLU A 1 100 ? 19.787 -25.362 -8.770  1.00 44.22  ? 81  GLU A CG  1 
ATOM   677  C CD  . GLU A 1 100 ? 19.079 -24.094 -8.306  1.00 56.86  ? 81  GLU A CD  1 
ATOM   678  O OE1 . GLU A 1 100 ? 18.946 -23.134 -9.132  1.00 52.85  ? 81  GLU A OE1 1 
ATOM   679  O OE2 . GLU A 1 100 ? 18.701 -24.045 -7.100  1.00 62.90  ? 81  GLU A OE2 1 
ATOM   680  N N   . ASN A 1 101 ? 24.008 -25.167 -10.824 1.00 25.06  ? 82  ASN A N   1 
ATOM   681  C CA  . ASN A 1 101 ? 24.829 -24.849 -12.030 1.00 23.89  ? 82  ASN A CA  1 
ATOM   682  C C   . ASN A 1 101 ? 26.143 -25.645 -12.031 1.00 23.80  ? 82  ASN A C   1 
ATOM   683  O O   . ASN A 1 101 ? 27.032 -25.328 -12.875 1.00 25.44  ? 82  ASN A O   1 
ATOM   684  C CB  . ASN A 1 101 ? 25.043 -23.335 -12.144 1.00 23.20  ? 82  ASN A CB  1 
ATOM   685  C CG  . ASN A 1 101 ? 23.725 -22.597 -12.243 1.00 23.45  ? 82  ASN A CG  1 
ATOM   686  O OD1 . ASN A 1 101 ? 23.430 -21.737 -11.417 1.00 26.14  ? 82  ASN A OD1 1 
ATOM   687  N ND2 . ASN A 1 101 ? 22.897 -22.985 -13.204 1.00 23.17  ? 82  ASN A ND2 1 
ATOM   688  N N   . VAL A 1 102 ? 26.253 -26.680 -11.192 1.00 23.20  ? 83  VAL A N   1 
ATOM   689  C CA  . VAL A 1 102 ? 27.500 -27.494 -11.038 1.00 23.05  ? 83  VAL A CA  1 
ATOM   690  C C   . VAL A 1 102 ? 27.132 -28.975 -11.024 1.00 24.16  ? 83  VAL A C   1 
ATOM   691  O O   . VAL A 1 102 ? 26.151 -29.325 -10.367 1.00 25.49  ? 83  VAL A O   1 
ATOM   692  C CB  . VAL A 1 102 ? 28.284 -27.122 -9.776  1.00 22.90  ? 83  VAL A CB  1 
ATOM   693  C CG1 . VAL A 1 102 ? 29.606 -27.884 -9.705  1.00 24.56  ? 83  VAL A CG1 1 
ATOM   694  C CG2 . VAL A 1 102 ? 28.549 -25.634 -9.690  1.00 21.54  ? 83  VAL A CG2 1 
ATOM   695  N N   . ILE A 1 103 ? 27.933 -29.785 -11.706 1.00 25.17  ? 84  ILE A N   1 
ATOM   696  C CA  . ILE A 1 103 ? 27.895 -31.275 -11.662 1.00 29.06  ? 84  ILE A CA  1 
ATOM   697  C C   . ILE A 1 103 ? 27.809 -31.701 -10.204 1.00 29.23  ? 84  ILE A C   1 
ATOM   698  O O   . ILE A 1 103 ? 28.597 -31.202 -9.431  1.00 32.64  ? 84  ILE A O   1 
ATOM   699  C CB  . ILE A 1 103 ? 29.144 -31.853 -12.335 1.00 29.72  ? 84  ILE A CB  1 
ATOM   700  C CG1 . ILE A 1 103 ? 29.120 -33.380 -12.402 1.00 31.87  ? 84  ILE A CG1 1 
ATOM   701  C CG2 . ILE A 1 103 ? 30.404 -31.344 -11.655 1.00 31.09  ? 84  ILE A CG2 1 
ATOM   702  C CD1 . ILE A 1 103 ? 30.388 -33.985 -13.036 1.00 34.72  ? 84  ILE A CD1 1 
ATOM   703  N N   . GLY A 1 104 ? 26.869 -32.568 -9.858  1.00 33.23  ? 85  GLY A N   1 
ATOM   704  C CA  . GLY A 1 104 ? 26.778 -33.172 -8.509  1.00 33.40  ? 85  GLY A CA  1 
ATOM   705  C C   . GLY A 1 104 ? 26.935 -34.684 -8.565  1.00 31.83  ? 85  GLY A C   1 
ATOM   706  O O   . GLY A 1 104 ? 26.768 -35.282 -9.659  1.00 28.67  ? 85  GLY A O   1 
ATOM   707  N N   . LEU A 1 105 ? 27.263 -35.319 -7.442  1.00 28.62  ? 86  LEU A N   1 
ATOM   708  C CA  . LEU A 1 105 ? 27.322 -36.800 -7.443  1.00 27.83  ? 86  LEU A CA  1 
ATOM   709  C C   . LEU A 1 105 ? 25.918 -37.355 -7.180  1.00 25.11  ? 86  LEU A C   1 
ATOM   710  O O   . LEU A 1 105 ? 25.407 -37.153 -6.085  1.00 27.60  ? 86  LEU A O   1 
ATOM   711  C CB  . LEU A 1 105 ? 28.314 -37.262 -6.392  1.00 28.21  ? 86  LEU A CB  1 
ATOM   712  C CG  . LEU A 1 105 ? 28.729 -38.716 -6.519  1.00 27.86  ? 86  LEU A CG  1 
ATOM   713  C CD1 . LEU A 1 105 ? 29.317 -38.965 -7.889  1.00 27.45  ? 86  LEU A CD1 1 
ATOM   714  C CD2 . LEU A 1 105 ? 29.705 -39.073 -5.401  1.00 29.54  ? 86  LEU A CD2 1 
ATOM   715  N N   . LEU A 1 106 ? 25.295 -37.951 -8.185  1.00 24.90  ? 87  LEU A N   1 
ATOM   716  C CA  . LEU A 1 106 ? 23.962 -38.591 -8.049  1.00 29.03  ? 87  LEU A CA  1 
ATOM   717  C C   . LEU A 1 106 ? 24.117 -39.913 -7.286  1.00 26.44  ? 87  LEU A C   1 
ATOM   718  O O   . LEU A 1 106 ? 23.308 -40.184 -6.444  1.00 27.23  ? 87  LEU A O   1 
ATOM   719  C CB  . LEU A 1 106 ? 23.346 -38.809 -9.432  1.00 29.61  ? 87  LEU A CB  1 
ATOM   720  C CG  . LEU A 1 106 ? 23.063 -37.519 -10.211 1.00 35.01  ? 87  LEU A CG  1 
ATOM   721  C CD1 . LEU A 1 106 ? 22.574 -37.815 -11.624 1.00 35.81  ? 87  LEU A CD1 1 
ATOM   722  C CD2 . LEU A 1 106 ? 22.062 -36.635 -9.490  1.00 34.36  ? 87  LEU A CD2 1 
ATOM   723  N N   . ASP A 1 107 ? 25.165 -40.666 -7.570  1.00 24.90  ? 88  ASP A N   1 
ATOM   724  C CA  . ASP A 1 107 ? 25.457 -41.963 -6.939  1.00 25.65  ? 88  ASP A CA  1 
ATOM   725  C C   . ASP A 1 107 ? 26.937 -42.273 -7.142  1.00 25.11  ? 88  ASP A C   1 
ATOM   726  O O   . ASP A 1 107 ? 27.555 -41.808 -8.131  1.00 23.48  ? 88  ASP A O   1 
ATOM   727  C CB  . ASP A 1 107 ? 24.602 -43.063 -7.568  1.00 26.86  ? 88  ASP A CB  1 
ATOM   728  C CG  . ASP A 1 107 ? 24.454 -44.331 -6.748  1.00 25.40  ? 88  ASP A CG  1 
ATOM   729  O OD1 . ASP A 1 107 ? 24.766 -44.324 -5.543  1.00 27.09  ? 88  ASP A OD1 1 
ATOM   730  O OD2 . ASP A 1 107 ? 24.033 -45.299 -7.328  1.00 24.61  ? 88  ASP A OD2 1 
ATOM   731  N N   . VAL A 1 108 ? 27.464 -43.091 -6.258  1.00 25.94  ? 89  VAL A N   1 
ATOM   732  C CA  . VAL A 1 108 ? 28.785 -43.756 -6.425  1.00 25.76  ? 89  VAL A CA  1 
ATOM   733  C C   . VAL A 1 108 ? 28.608 -45.153 -5.828  1.00 25.40  ? 89  VAL A C   1 
ATOM   734  O O   . VAL A 1 108 ? 27.981 -45.268 -4.755  1.00 22.50  ? 89  VAL A O   1 
ATOM   735  C CB  . VAL A 1 108 ? 29.909 -42.942 -5.747  1.00 26.02  ? 89  VAL A CB  1 
ATOM   736  C CG1 . VAL A 1 108 ? 29.539 -42.526 -4.328  1.00 27.32  ? 89  VAL A CG1 1 
ATOM   737  C CG2 . VAL A 1 108 ? 31.246 -43.663 -5.744  1.00 25.24  ? 89  VAL A CG2 1 
ATOM   738  N N   . PHE A 1 109 ? 29.066 -46.186 -6.530  1.00 24.34  ? 90  PHE A N   1 
ATOM   739  C CA  . PHE A 1 109 ? 28.920 -47.577 -6.055  1.00 28.29  ? 90  PHE A CA  1 
ATOM   740  C C   . PHE A 1 109 ? 30.147 -48.395 -6.455  1.00 26.34  ? 90  PHE A C   1 
ATOM   741  O O   . PHE A 1 109 ? 30.930 -47.991 -7.352  1.00 25.75  ? 90  PHE A O   1 
ATOM   742  C CB  . PHE A 1 109 ? 27.607 -48.196 -6.557  1.00 26.81  ? 90  PHE A CB  1 
ATOM   743  C CG  . PHE A 1 109 ? 27.491 -48.249 -8.054  1.00 25.31  ? 90  PHE A CG  1 
ATOM   744  C CD1 . PHE A 1 109 ? 26.738 -47.308 -8.747  1.00 26.31  ? 90  PHE A CD1 1 
ATOM   745  C CD2 . PHE A 1 109 ? 28.127 -49.234 -8.770  1.00 23.45  ? 90  PHE A CD2 1 
ATOM   746  C CE1 . PHE A 1 109 ? 26.621 -47.377 -10.124 1.00 24.08  ? 90  PHE A CE1 1 
ATOM   747  C CE2 . PHE A 1 109 ? 28.028 -49.279 -10.149 1.00 24.60  ? 90  PHE A CE2 1 
ATOM   748  C CZ  . PHE A 1 109 ? 27.277 -48.354 -10.827 1.00 21.75  ? 90  PHE A CZ  1 
ATOM   749  N N   . THR A 1 110 ? 30.314 -49.509 -5.744  1.00 26.67  ? 91  THR A N   1 
ATOM   750  C CA  . THR A 1 110 ? 31.211 -50.623 -6.113  1.00 26.68  ? 91  THR A CA  1 
ATOM   751  C C   . THR A 1 110 ? 30.445 -51.922 -5.933  1.00 27.04  ? 91  THR A C   1 
ATOM   752  O O   . THR A 1 110 ? 29.643 -52.037 -5.018  1.00 27.27  ? 91  THR A O   1 
ATOM   753  C CB  . THR A 1 110 ? 32.485 -50.590 -5.260  1.00 28.08  ? 91  THR A CB  1 
ATOM   754  O OG1 . THR A 1 110 ? 33.301 -51.700 -5.647  1.00 28.71  ? 91  THR A OG1 1 
ATOM   755  C CG2 . THR A 1 110 ? 32.205 -50.614 -3.771  1.00 27.39  ? 91  THR A CG2 1 
ATOM   756  N N   . PRO A 1 111 ? 30.687 -52.944 -6.771  1.00 31.43  ? 92  PRO A N   1 
ATOM   757  C CA  . PRO A 1 111 ? 30.217 -54.307 -6.494  1.00 35.59  ? 92  PRO A CA  1 
ATOM   758  C C   . PRO A 1 111 ? 30.823 -54.927 -5.221  1.00 37.77  ? 92  PRO A C   1 
ATOM   759  O O   . PRO A 1 111 ? 30.222 -55.836 -4.676  1.00 40.49  ? 92  PRO A O   1 
ATOM   760  C CB  . PRO A 1 111 ? 30.685 -55.143 -7.691  1.00 36.08  ? 92  PRO A CB  1 
ATOM   761  C CG  . PRO A 1 111 ? 31.052 -54.128 -8.749  1.00 36.27  ? 92  PRO A CG  1 
ATOM   762  C CD  . PRO A 1 111 ? 31.420 -52.847 -8.032  1.00 33.39  ? 92  PRO A CD  1 
ATOM   763  N N   . ALA A 1 112 ? 31.952 -54.384 -4.753  1.00 36.68  ? 93  ALA A N   1 
ATOM   764  C CA  . ALA A 1 112 ? 32.710 -54.870 -3.579  1.00 38.06  ? 93  ALA A CA  1 
ATOM   765  C C   . ALA A 1 112 ? 31.825 -54.842 -2.338  1.00 37.36  ? 93  ALA A C   1 
ATOM   766  O O   . ALA A 1 112 ? 31.187 -53.790 -2.071  1.00 34.39  ? 93  ALA A O   1 
ATOM   767  C CB  . ALA A 1 112 ? 33.959 -54.035 -3.369  1.00 38.46  ? 93  ALA A CB  1 
ATOM   768  N N   . ARG A 1 113 ? 31.871 -55.933 -1.573  1.00 39.15  ? 94  ARG A N   1 
ATOM   769  C CA  . ARG A 1 113 ? 31.213 -56.070 -0.251  1.00 41.06  ? 94  ARG A CA  1 
ATOM   770  C C   . ARG A 1 113 ? 32.219 -55.763 0.855   1.00 37.59  ? 94  ARG A C   1 
ATOM   771  O O   . ARG A 1 113 ? 31.766 -55.603 1.990   1.00 41.20  ? 94  ARG A O   1 
ATOM   772  C CB  . ARG A 1 113 ? 30.643 -57.480 -0.078  1.00 50.13  ? 94  ARG A CB  1 
ATOM   773  C CG  . ARG A 1 113 ? 29.586 -57.852 -1.111  1.00 54.23  ? 94  ARG A CG  1 
ATOM   774  C CD  . ARG A 1 113 ? 29.326 -59.353 -1.163  1.00 57.06  ? 94  ARG A CD  1 
ATOM   775  N NE  . ARG A 1 113 ? 28.225 -59.766 -2.033  1.00 57.59  ? 94  ARG A NE  1 
ATOM   776  C CZ  . ARG A 1 113 ? 26.928 -59.605 -1.742  1.00 62.28  ? 94  ARG A CZ  1 
ATOM   777  N NH1 . ARG A 1 113 ? 26.537 -59.006 -0.625  1.00 61.63  ? 94  ARG A NH1 1 
ATOM   778  N NH2 . ARG A 1 113 ? 26.014 -60.035 -2.592  1.00 63.88  ? 94  ARG A NH2 1 
ATOM   779  N N   . SER A 1 114 ? 33.513 -55.652 0.536   1.00 33.28  ? 95  SER A N   1 
ATOM   780  C CA  . SER A 1 114 ? 34.569 -55.284 1.521   1.00 33.65  ? 95  SER A CA  1 
ATOM   781  C C   . SER A 1 114 ? 35.712 -54.491 0.889   1.00 30.97  ? 95  SER A C   1 
ATOM   782  O O   . SER A 1 114 ? 35.887 -54.509 -0.333  1.00 32.95  ? 95  SER A O   1 
ATOM   783  C CB  . SER A 1 114 ? 35.142 -56.517 2.151   1.00 34.14  ? 95  SER A CB  1 
ATOM   784  O OG  . SER A 1 114 ? 35.984 -57.176 1.210   1.00 33.29  ? 95  SER A OG  1 
ATOM   785  N N   . LEU A 1 115 ? 36.561 -53.932 1.739   1.00 33.69  ? 96  LEU A N   1 
ATOM   786  C CA  . LEU A 1 115 ? 37.793 -53.229 1.330   1.00 31.95  ? 96  LEU A CA  1 
ATOM   787  C C   . LEU A 1 115 ? 38.705 -54.195 0.577   1.00 35.17  ? 96  LEU A C   1 
ATOM   788  O O   . LEU A 1 115 ? 39.287 -53.794 -0.465  1.00 35.81  ? 96  LEU A O   1 
ATOM   789  C CB  . LEU A 1 115 ? 38.456 -52.660 2.583   1.00 32.20  ? 96  LEU A CB  1 
ATOM   790  C CG  . LEU A 1 115 ? 39.783 -51.943 2.334   1.00 32.59  ? 96  LEU A CG  1 
ATOM   791  C CD1 . LEU A 1 115 ? 39.591 -50.789 1.353   1.00 30.96  ? 96  LEU A CD1 1 
ATOM   792  C CD2 . LEU A 1 115 ? 40.392 -51.499 3.652   1.00 30.94  ? 96  LEU A CD2 1 
ATOM   793  N N   . GLU A 1 116 ? 38.768 -55.447 1.018   1.00 41.23  ? 97  GLU A N   1 
ATOM   794  C CA  . GLU A 1 116 ? 39.699 -56.443 0.423   1.00 44.72  ? 97  GLU A CA  1 
ATOM   795  C C   . GLU A 1 116 ? 39.306 -56.664 -1.036  1.00 43.20  ? 97  GLU A C   1 
ATOM   796  O O   . GLU A 1 116 ? 40.217 -56.823 -1.840  1.00 39.52  ? 97  GLU A O   1 
ATOM   797  C CB  . GLU A 1 116 ? 39.709 -57.760 1.197   1.00 51.78  ? 97  GLU A CB  1 
ATOM   798  C CG  . GLU A 1 116 ? 40.251 -57.623 2.615   1.00 62.95  ? 97  GLU A CG  1 
ATOM   799  C CD  . GLU A 1 116 ? 39.396 -56.807 3.583   1.00 75.75  ? 97  GLU A CD  1 
ATOM   800  O OE1 . GLU A 1 116 ? 38.178 -56.625 3.304   1.00 69.84  ? 97  GLU A OE1 1 
ATOM   801  O OE2 . GLU A 1 116 ? 39.953 -56.321 4.607   1.00 82.29  ? 97  GLU A OE2 1 
ATOM   802  N N   . GLU A 1 117 ? 38.014 -56.620 -1.379  1.00 46.18  ? 98  GLU A N   1 
ATOM   803  C CA  . GLU A 1 117 ? 37.596 -56.906 -2.782  1.00 51.59  ? 98  GLU A CA  1 
ATOM   804  C C   . GLU A 1 117 ? 37.316 -55.610 -3.559  1.00 47.09  ? 98  GLU A C   1 
ATOM   805  O O   . GLU A 1 117 ? 37.081 -55.698 -4.776  1.00 44.28  ? 98  GLU A O   1 
ATOM   806  C CB  . GLU A 1 117 ? 36.434 -57.901 -2.840  1.00 58.60  ? 98  GLU A CB  1 
ATOM   807  C CG  . GLU A 1 117 ? 35.121 -57.426 -2.261  1.00 68.67  ? 98  GLU A CG  1 
ATOM   808  C CD  . GLU A 1 117 ? 33.965 -58.374 -2.577  1.00 77.47  ? 98  GLU A CD  1 
ATOM   809  O OE1 . GLU A 1 117 ? 34.206 -59.442 -3.180  1.00 81.17  ? 98  GLU A OE1 1 
ATOM   810  O OE2 . GLU A 1 117 ? 32.816 -58.029 -2.253  1.00 80.28  ? 98  GLU A OE2 1 
ATOM   811  N N   . PHE A 1 118 ? 37.421 -54.447 -2.918  1.00 40.46  ? 99  PHE A N   1 
ATOM   812  C CA  . PHE A 1 118 ? 37.262 -53.118 -3.564  1.00 34.91  ? 99  PHE A CA  1 
ATOM   813  C C   . PHE A 1 118 ? 38.383 -52.865 -4.575  1.00 34.31  ? 99  PHE A C   1 
ATOM   814  O O   . PHE A 1 118 ? 39.509 -52.594 -4.170  1.00 35.20  ? 99  PHE A O   1 
ATOM   815  C CB  . PHE A 1 118 ? 37.213 -52.049 -2.476  1.00 33.90  ? 99  PHE A CB  1 
ATOM   816  C CG  . PHE A 1 118 ? 36.986 -50.648 -2.963  1.00 31.40  ? 99  PHE A CG  1 
ATOM   817  C CD1 . PHE A 1 118 ? 35.912 -50.361 -3.801  1.00 31.97  ? 99  PHE A CD1 1 
ATOM   818  C CD2 . PHE A 1 118 ? 37.801 -49.612 -2.527  1.00 27.07  ? 99  PHE A CD2 1 
ATOM   819  C CE1 . PHE A 1 118 ? 35.660 -49.052 -4.194  1.00 29.39  ? 99  PHE A CE1 1 
ATOM   820  C CE2 . PHE A 1 118 ? 37.583 -48.319 -2.966  1.00 26.85  ? 99  PHE A CE2 1 
ATOM   821  C CZ  . PHE A 1 118 ? 36.506 -48.041 -3.795  1.00 28.84  ? 99  PHE A CZ  1 
ATOM   822  N N   . ASN A 1 119 ? 38.065 -52.925 -5.869  1.00 34.07  ? 100 ASN A N   1 
ATOM   823  C CA  . ASN A 1 119 ? 38.979 -52.570 -6.982  1.00 39.97  ? 100 ASN A CA  1 
ATOM   824  C C   . ASN A 1 119 ? 38.335 -51.595 -7.979  1.00 39.82  ? 100 ASN A C   1 
ATOM   825  O O   . ASN A 1 119 ? 39.069 -51.000 -8.773  1.00 44.14  ? 100 ASN A O   1 
ATOM   826  C CB  . ASN A 1 119 ? 39.414 -53.821 -7.751  1.00 47.70  ? 100 ASN A CB  1 
ATOM   827  C CG  . ASN A 1 119 ? 40.397 -54.676 -6.978  1.00 55.49  ? 100 ASN A CG  1 
ATOM   828  O OD1 . ASN A 1 119 ? 41.484 -54.211 -6.629  1.00 60.77  ? 100 ASN A OD1 1 
ATOM   829  N ND2 . ASN A 1 119 ? 40.043 -55.928 -6.730  1.00 60.35  ? 100 ASN A ND2 1 
ATOM   830  N N   . ASP A 1 120 ? 37.015 -51.474 -8.011  1.00 41.04  ? 101 ASP A N   1 
ATOM   831  C CA  . ASP A 1 120 ? 36.335 -50.697 -9.074  1.00 38.15  ? 101 ASP A CA  1 
ATOM   832  C C   . ASP A 1 120 ? 35.459 -49.638 -8.420  1.00 35.74  ? 101 ASP A C   1 
ATOM   833  O O   . ASP A 1 120 ? 34.854 -49.932 -7.384  1.00 35.64  ? 101 ASP A O   1 
ATOM   834  C CB  . ASP A 1 120 ? 35.535 -51.623 -9.980  1.00 41.46  ? 101 ASP A CB  1 
ATOM   835  C CG  . ASP A 1 120 ? 36.411 -52.341 -10.989 1.00 51.62  ? 101 ASP A CG  1 
ATOM   836  O OD1 . ASP A 1 120 ? 37.415 -51.742 -11.457 1.00 57.82  ? 101 ASP A OD1 1 
ATOM   837  O OD2 . ASP A 1 120 ? 36.086 -53.479 -11.299 1.00 58.75  ? 101 ASP A OD2 1 
ATOM   838  N N   . VAL A 1 121 ? 35.403 -48.471 -9.042  1.00 29.23  ? 102 VAL A N   1 
ATOM   839  C CA  . VAL A 1 121 ? 34.620 -47.294 -8.596  1.00 32.44  ? 102 VAL A CA  1 
ATOM   840  C C   . VAL A 1 121 ? 33.815 -46.808 -9.800  1.00 30.81  ? 102 VAL A C   1 
ATOM   841  O O   . VAL A 1 121 ? 34.425 -46.558 -10.862 1.00 32.35  ? 102 VAL A O   1 
ATOM   842  C CB  . VAL A 1 121 ? 35.552 -46.182 -8.095  1.00 32.37  ? 102 VAL A CB  1 
ATOM   843  C CG1 . VAL A 1 121 ? 34.800 -44.932 -7.738  1.00 36.21  ? 102 VAL A CG1 1 
ATOM   844  C CG2 . VAL A 1 121 ? 36.379 -46.648 -6.919  1.00 37.11  ? 102 VAL A CG2 1 
ATOM   845  N N   . TYR A 1 122 ? 32.508 -46.668 -9.616  1.00 27.61  ? 103 TYR A N   1 
ATOM   846  C CA  . TYR A 1 122 ? 31.578 -46.114 -10.615 1.00 26.91  ? 103 TYR A CA  1 
ATOM   847  C C   . TYR A 1 122 ? 30.993 -44.833 -10.038 1.00 26.48  ? 103 TYR A C   1 
ATOM   848  O O   . TYR A 1 122 ? 30.492 -44.878 -8.890  1.00 25.68  ? 103 TYR A O   1 
ATOM   849  C CB  . TYR A 1 122 ? 30.462 -47.108 -10.924 1.00 26.95  ? 103 TYR A CB  1 
ATOM   850  C CG  . TYR A 1 122 ? 30.866 -48.426 -11.520 1.00 25.80  ? 103 TYR A CG  1 
ATOM   851  C CD1 . TYR A 1 122 ? 31.385 -49.425 -10.724 1.00 27.95  ? 103 TYR A CD1 1 
ATOM   852  C CD2 . TYR A 1 122 ? 30.660 -48.709 -12.859 1.00 26.56  ? 103 TYR A CD2 1 
ATOM   853  C CE1 . TYR A 1 122 ? 31.722 -50.663 -11.245 1.00 26.75  ? 103 TYR A CE1 1 
ATOM   854  C CE2 . TYR A 1 122 ? 30.979 -49.941 -13.393 1.00 25.24  ? 103 TYR A CE2 1 
ATOM   855  C CZ  . TYR A 1 122 ? 31.529 -50.925 -12.587 1.00 27.61  ? 103 TYR A CZ  1 
ATOM   856  O OH  . TYR A 1 122 ? 31.889 -52.151 -13.097 1.00 27.80  ? 103 TYR A OH  1 
ATOM   857  N N   . LEU A 1 123 ? 31.042 -43.751 -10.817 1.00 24.94  ? 104 LEU A N   1 
ATOM   858  C CA  . LEU A 1 123 ? 30.502 -42.417 -10.466 1.00 23.91  ? 104 LEU A CA  1 
ATOM   859  C C   . LEU A 1 123 ? 29.335 -42.131 -11.404 1.00 25.38  ? 104 LEU A C   1 
ATOM   860  O O   . LEU A 1 123 ? 29.488 -42.351 -12.615 1.00 26.00  ? 104 LEU A O   1 
ATOM   861  C CB  . LEU A 1 123 ? 31.581 -41.350 -10.648 1.00 24.84  ? 104 LEU A CB  1 
ATOM   862  C CG  . LEU A 1 123 ? 32.833 -41.552 -9.815  1.00 27.61  ? 104 LEU A CG  1 
ATOM   863  C CD1 . LEU A 1 123 ? 33.930 -40.628 -10.289 1.00 32.12  ? 104 LEU A CD1 1 
ATOM   864  C CD2 . LEU A 1 123 ? 32.568 -41.316 -8.342  1.00 29.76  ? 104 LEU A CD2 1 
ATOM   865  N N   . VAL A 1 124 ? 28.205 -41.717 -10.840 1.00 25.37  ? 105 VAL A N   1 
ATOM   866  C CA  . VAL A 1 124 ? 26.964 -41.424 -11.591 1.00 25.50  ? 105 VAL A CA  1 
ATOM   867  C C   . VAL A 1 124 ? 26.704 -39.928 -11.442 1.00 26.14  ? 105 VAL A C   1 
ATOM   868  O O   . VAL A 1 124 ? 26.673 -39.426 -10.283 1.00 25.23  ? 105 VAL A O   1 
ATOM   869  C CB  . VAL A 1 124 ? 25.772 -42.268 -11.108 1.00 24.34  ? 105 VAL A CB  1 
ATOM   870  C CG1 . VAL A 1 124 ? 24.502 -41.917 -11.873 1.00 24.89  ? 105 VAL A CG1 1 
ATOM   871  C CG2 . VAL A 1 124 ? 26.066 -43.747 -11.189 1.00 24.35  ? 105 VAL A CG2 1 
ATOM   872  N N   . THR A 1 125 ? 26.629 -39.240 -12.570 1.00 28.41  ? 106 THR A N   1 
ATOM   873  C CA  . THR A 1 125 ? 26.565 -37.747 -12.641 1.00 32.43  ? 106 THR A CA  1 
ATOM   874  C C   . THR A 1 125 ? 25.602 -37.362 -13.749 1.00 32.71  ? 106 THR A C   1 
ATOM   875  O O   . THR A 1 125 ? 25.143 -38.273 -14.471 1.00 38.05  ? 106 THR A O   1 
ATOM   876  C CB  . THR A 1 125 ? 27.946 -37.118 -12.883 1.00 32.82  ? 106 THR A CB  1 
ATOM   877  O OG1 . THR A 1 125 ? 28.508 -37.636 -14.094 1.00 34.83  ? 106 THR A OG1 1 
ATOM   878  C CG2 . THR A 1 125 ? 28.913 -37.405 -11.754 1.00 32.67  ? 106 THR A CG2 1 
ATOM   879  N N   . HIS A 1 126 ? 25.270 -36.078 -13.823 1.00 40.62  ? 107 HIS A N   1 
ATOM   880  C CA  . HIS A 1 126 ? 24.387 -35.478 -14.861 1.00 46.80  ? 107 HIS A CA  1 
ATOM   881  C C   . HIS A 1 126 ? 24.882 -35.877 -16.256 1.00 39.41  ? 107 HIS A C   1 
ATOM   882  O O   . HIS A 1 126 ? 26.112 -35.698 -16.539 1.00 37.36  ? 107 HIS A O   1 
ATOM   883  C CB  . HIS A 1 126 ? 24.329 -33.954 -14.721 1.00 48.37  ? 107 HIS A CB  1 
ATOM   884  C CG  . HIS A 1 126 ? 23.752 -33.268 -15.915 1.00 54.28  ? 107 HIS A CG  1 
ATOM   885  N ND1 . HIS A 1 126 ? 22.387 -33.083 -16.080 1.00 55.10  ? 107 HIS A ND1 1 
ATOM   886  C CD2 . HIS A 1 126 ? 24.353 -32.693 -16.988 1.00 53.11  ? 107 HIS A CD2 1 
ATOM   887  C CE1 . HIS A 1 126 ? 22.172 -32.440 -17.218 1.00 59.26  ? 107 HIS A CE1 1 
ATOM   888  N NE2 . HIS A 1 126 ? 23.362 -32.183 -17.792 1.00 54.14  ? 107 HIS A NE2 1 
ATOM   889  N N   . LEU A 1 127 ? 23.988 -36.439 -17.074 1.00 40.67  ? 108 LEU A N   1 
ATOM   890  C CA  . LEU A 1 127 ? 24.322 -36.813 -18.473 1.00 45.72  ? 108 LEU A CA  1 
ATOM   891  C C   . LEU A 1 127 ? 24.485 -35.528 -19.281 1.00 44.93  ? 108 LEU A C   1 
ATOM   892  O O   . LEU A 1 127 ? 23.621 -34.647 -19.148 1.00 45.71  ? 108 LEU A O   1 
ATOM   893  C CB  . LEU A 1 127 ? 23.233 -37.682 -19.109 1.00 42.48  ? 108 LEU A CB  1 
ATOM   894  C CG  . LEU A 1 127 ? 23.630 -38.288 -20.457 1.00 41.54  ? 108 LEU A CG  1 
ATOM   895  C CD1 . LEU A 1 127 ? 24.932 -39.075 -20.354 1.00 42.87  ? 108 LEU A CD1 1 
ATOM   896  C CD2 . LEU A 1 127 ? 22.538 -39.187 -20.985 1.00 43.19  ? 108 LEU A CD2 1 
ATOM   897  N N   . MET A 1 128 ? 25.560 -35.446 -20.061 1.00 53.13  ? 109 MET A N   1 
ATOM   898  C CA  . MET A 1 128 ? 25.814 -34.363 -21.055 1.00 63.66  ? 109 MET A CA  1 
ATOM   899  C C   . MET A 1 128 ? 24.832 -34.520 -22.226 1.00 55.55  ? 109 MET A C   1 
ATOM   900  O O   . MET A 1 128 ? 25.208 -35.147 -23.216 1.00 62.61  ? 109 MET A O   1 
ATOM   901  C CB  . MET A 1 128 ? 27.252 -34.450 -21.595 1.00 64.02  ? 109 MET A CB  1 
ATOM   902  C CG  . MET A 1 128 ? 28.147 -33.341 -21.124 1.00 68.93  ? 109 MET A CG  1 
ATOM   903  S SD  . MET A 1 128 ? 27.970 -31.858 -22.135 1.00 61.21  ? 109 MET A SD  1 
ATOM   904  C CE  . MET A 1 128 ? 29.166 -30.749 -21.378 1.00 62.99  ? 109 MET A CE  1 
ATOM   905  N N   . GLY A 1 129 ? 23.605 -34.016 -22.114 1.00 58.84  ? 110 GLY A N   1 
ATOM   906  C CA  . GLY A 1 129 ? 22.632 -34.086 -23.229 1.00 64.47  ? 110 GLY A CA  1 
ATOM   907  C C   . GLY A 1 129 ? 23.098 -33.248 -24.418 1.00 56.38  ? 110 GLY A C   1 
ATOM   908  O O   . GLY A 1 129 ? 23.148 -33.756 -25.533 1.00 66.76  ? 110 GLY A O   1 
ATOM   909  N N   . ALA A 1 130 ? 23.477 -32.002 -24.166 1.00 45.24  ? 111 ALA A N   1 
ATOM   910  C CA  . ALA A 1 130 ? 24.121 -31.111 -25.153 1.00 37.11  ? 111 ALA A CA  1 
ATOM   911  C C   . ALA A 1 130 ? 25.127 -30.243 -24.414 1.00 29.26  ? 111 ALA A C   1 
ATOM   912  O O   . ALA A 1 130 ? 24.858 -29.874 -23.279 1.00 29.30  ? 111 ALA A O   1 
ATOM   913  C CB  . ALA A 1 130 ? 23.091 -30.274 -25.873 1.00 34.76  ? 111 ALA A CB  1 
ATOM   914  N N   . ASP A 1 131 ? 26.263 -29.961 -25.045 1.00 26.69  ? 112 ASP A N   1 
ATOM   915  C CA  . ASP A 1 131 ? 27.223 -28.954 -24.544 1.00 25.28  ? 112 ASP A CA  1 
ATOM   916  C C   . ASP A 1 131 ? 26.881 -27.611 -25.206 1.00 24.32  ? 112 ASP A C   1 
ATOM   917  O O   . ASP A 1 131 ? 25.953 -27.578 -26.058 1.00 22.35  ? 112 ASP A O   1 
ATOM   918  C CB  . ASP A 1 131 ? 28.652 -29.475 -24.702 1.00 25.60  ? 112 ASP A CB  1 
ATOM   919  C CG  . ASP A 1 131 ? 29.144 -29.580 -26.130 1.00 26.26  ? 112 ASP A CG  1 
ATOM   920  O OD1 . ASP A 1 131 ? 28.538 -28.940 -27.020 1.00 23.95  ? 112 ASP A OD1 1 
ATOM   921  O OD2 . ASP A 1 131 ? 30.164 -30.295 -26.311 1.00 25.54  ? 112 ASP A OD2 1 
ATOM   922  N N   . LEU A 1 132 ? 27.586 -26.542 -24.821 1.00 23.13  ? 113 LEU A N   1 
ATOM   923  C CA  . LEU A 1 132 ? 27.331 -25.183 -25.350 1.00 22.81  ? 113 LEU A CA  1 
ATOM   924  C C   . LEU A 1 132 ? 27.599 -25.153 -26.862 1.00 21.45  ? 113 LEU A C   1 
ATOM   925  O O   . LEU A 1 132 ? 26.884 -24.465 -27.562 1.00 23.78  ? 113 LEU A O   1 
ATOM   926  C CB  . LEU A 1 132 ? 28.182 -24.170 -24.569 1.00 22.30  ? 113 LEU A CB  1 
ATOM   927  C CG  . LEU A 1 132 ? 27.938 -22.717 -24.940 1.00 23.32  ? 113 LEU A CG  1 
ATOM   928  C CD1 . LEU A 1 132 ? 26.495 -22.293 -24.650 1.00 23.58  ? 113 LEU A CD1 1 
ATOM   929  C CD2 . LEU A 1 132 ? 28.917 -21.833 -24.220 1.00 24.73  ? 113 LEU A CD2 1 
ATOM   930  N N   . ASN A 1 133 ? 28.563 -25.916 -27.365 1.00 23.22  ? 114 ASN A N   1 
ATOM   931  C CA  . ASN A 1 133 ? 28.816 -26.017 -28.831 1.00 25.81  ? 114 ASN A CA  1 
ATOM   932  C C   . ASN A 1 133 ? 27.584 -26.586 -29.552 1.00 25.80  ? 114 ASN A C   1 
ATOM   933  O O   . ASN A 1 133 ? 27.282 -26.093 -30.629 1.00 24.05  ? 114 ASN A O   1 
ATOM   934  C CB  . ASN A 1 133 ? 30.066 -26.842 -29.178 1.00 27.74  ? 114 ASN A CB  1 
ATOM   935  C CG  . ASN A 1 133 ? 31.362 -26.178 -28.760 1.00 29.98  ? 114 ASN A CG  1 
ATOM   936  O OD1 . ASN A 1 133 ? 32.239 -26.847 -28.202 1.00 38.33  ? 114 ASN A OD1 1 
ATOM   937  N ND2 . ASN A 1 133 ? 31.473 -24.869 -28.962 1.00 27.23  ? 114 ASN A ND2 1 
ATOM   938  N N   . ASN A 1 134 ? 26.920 -27.622 -29.024 1.00 26.62  ? 115 ASN A N   1 
ATOM   939  C CA  . ASN A 1 134 ? 25.721 -28.197 -29.684 1.00 26.58  ? 115 ASN A CA  1 
ATOM   940  C C   . ASN A 1 134 ? 24.657 -27.095 -29.814 1.00 26.77  ? 115 ASN A C   1 
ATOM   941  O O   . ASN A 1 134 ? 23.953 -27.026 -30.853 1.00 22.65  ? 115 ASN A O   1 
ATOM   942  C CB  . ASN A 1 134 ? 25.157 -29.399 -28.915 1.00 33.33  ? 115 ASN A CB  1 
ATOM   943  C CG  . ASN A 1 134 ? 26.093 -30.602 -28.894 1.00 43.70  ? 115 ASN A CG  1 
ATOM   944  O OD1 . ASN A 1 134 ? 26.514 -31.099 -27.832 1.00 42.06  ? 115 ASN A OD1 1 
ATOM   945  N ND2 . ASN A 1 134 ? 26.442 -31.083 -30.077 1.00 48.19  ? 115 ASN A ND2 1 
ATOM   946  N N   . ILE A 1 135 ? 24.521 -26.250 -28.791 1.00 22.15  ? 116 ILE A N   1 
ATOM   947  C CA  . ILE A 1 135 ? 23.486 -25.195 -28.790 1.00 24.50  ? 116 ILE A CA  1 
ATOM   948  C C   . ILE A 1 135 ? 23.829 -24.197 -29.906 1.00 24.84  ? 116 ILE A C   1 
ATOM   949  O O   . ILE A 1 135 ? 22.918 -23.826 -30.677 1.00 25.38  ? 116 ILE A O   1 
ATOM   950  C CB  . ILE A 1 135 ? 23.391 -24.529 -27.407 1.00 25.27  ? 116 ILE A CB  1 
ATOM   951  C CG1 . ILE A 1 135 ? 23.033 -25.527 -26.307 1.00 29.10  ? 116 ILE A CG1 1 
ATOM   952  C CG2 . ILE A 1 135 ? 22.420 -23.373 -27.448 1.00 28.20  ? 116 ILE A CG2 1 
ATOM   953  C CD1 . ILE A 1 135 ? 21.725 -26.224 -26.510 1.00 29.54  ? 116 ILE A CD1 1 
ATOM   954  N N   . VAL A 1 136 ? 25.075 -23.740 -29.968 1.00 23.31  ? 117 VAL A N   1 
ATOM   955  C CA  . VAL A 1 136 ? 25.525 -22.752 -30.987 1.00 25.05  ? 117 VAL A CA  1 
ATOM   956  C C   . VAL A 1 136 ? 25.323 -23.357 -32.391 1.00 26.70  ? 117 VAL A C   1 
ATOM   957  O O   . VAL A 1 136 ? 24.853 -22.646 -33.319 1.00 24.25  ? 117 VAL A O   1 
ATOM   958  C CB  . VAL A 1 136 ? 26.979 -22.348 -30.730 1.00 25.71  ? 117 VAL A CB  1 
ATOM   959  C CG1 . VAL A 1 136 ? 27.550 -21.581 -31.904 1.00 26.05  ? 117 VAL A CG1 1 
ATOM   960  C CG2 . VAL A 1 136 ? 27.079 -21.546 -29.454 1.00 25.98  ? 117 VAL A CG2 1 
ATOM   961  N N   . LYS A 1 137 ? 25.557 -24.657 -32.512 1.00 24.22  ? 118 LYS A N   1 
ATOM   962  C CA  . LYS A 1 137 ? 25.437 -25.375 -33.795 1.00 27.15  ? 118 LYS A CA  1 
ATOM   963  C C   . LYS A 1 137 ? 24.014 -25.255 -34.353 1.00 26.57  ? 118 LYS A C   1 
ATOM   964  O O   . LYS A 1 137 ? 23.896 -25.023 -35.562 1.00 27.14  ? 118 LYS A O   1 
ATOM   965  C CB  . LYS A 1 137 ? 25.815 -26.838 -33.619 1.00 28.72  ? 118 LYS A CB  1 
ATOM   966  C CG  . LYS A 1 137 ? 25.844 -27.610 -34.917 1.00 33.88  ? 118 LYS A CG  1 
ATOM   967  C CD  . LYS A 1 137 ? 26.028 -29.096 -34.746 1.00 37.44  ? 118 LYS A CD  1 
ATOM   968  C CE  . LYS A 1 137 ? 26.147 -29.755 -36.099 1.00 41.67  ? 118 LYS A CE  1 
ATOM   969  N NZ  . LYS A 1 137 ? 25.828 -31.192 -36.020 1.00 46.41  ? 118 LYS A NZ  1 
ATOM   970  N N   . CYS A 1 138 ? 22.977 -25.373 -33.533 1.00 23.37  ? 119 CYS A N   1 
ATOM   971  C CA  . CYS A 1 138 ? 21.599 -25.620 -34.034 1.00 23.69  ? 119 CYS A CA  1 
ATOM   972  C C   . CYS A 1 138 ? 20.727 -24.360 -34.008 1.00 23.62  ? 119 CYS A C   1 
ATOM   973  O O   . CYS A 1 138 ? 19.595 -24.468 -34.488 1.00 23.03  ? 119 CYS A O   1 
ATOM   974  C CB  . CYS A 1 138 ? 20.941 -26.744 -33.243 1.00 26.25  ? 119 CYS A CB  1 
ATOM   975  S SG  . CYS A 1 138 ? 21.939 -28.262 -33.235 1.00 29.13  ? 119 CYS A SG  1 
ATOM   976  N N   . GLN A 1 139 ? 21.204 -23.215 -33.486 1.00 22.44  ? 120 GLN A N   1 
ATOM   977  C CA  . GLN A 1 139 ? 20.417 -21.962 -33.478 1.00 22.13  ? 120 GLN A CA  1 
ATOM   978  C C   . GLN A 1 139 ? 21.302 -20.752 -33.186 1.00 22.17  ? 120 GLN A C   1 
ATOM   979  O O   . GLN A 1 139 ? 22.404 -20.905 -32.670 1.00 23.16  ? 120 GLN A O   1 
ATOM   980  C CB  . GLN A 1 139 ? 19.277 -22.000 -32.451 1.00 23.48  ? 120 GLN A CB  1 
ATOM   981  C CG  . GLN A 1 139 ? 19.742 -22.239 -31.007 1.00 24.21  ? 120 GLN A CG  1 
ATOM   982  C CD  . GLN A 1 139 ? 19.295 -23.610 -30.538 1.00 23.89  ? 120 GLN A CD  1 
ATOM   983  O OE1 . GLN A 1 139 ? 18.112 -23.895 -30.496 1.00 22.22  ? 120 GLN A OE1 1 
ATOM   984  N NE2 . GLN A 1 139 ? 20.227 -24.476 -30.183 1.00 25.26  ? 120 GLN A NE2 1 
ATOM   985  N N   . LYS A 1 140 ? 20.770 -19.573 -33.467 1.00 22.22  ? 121 LYS A N   1 
ATOM   986  C CA  . LYS A 1 140 ? 21.404 -18.301 -33.099 1.00 25.11  ? 121 LYS A CA  1 
ATOM   987  C C   . LYS A 1 140 ? 20.894 -17.921 -31.712 1.00 25.54  ? 121 LYS A C   1 
ATOM   988  O O   . LYS A 1 140 ? 19.689 -17.772 -31.549 1.00 27.69  ? 121 LYS A O   1 
ATOM   989  C CB  . LYS A 1 140 ? 21.055 -17.232 -34.130 1.00 28.07  ? 121 LYS A CB  1 
ATOM   990  C CG  . LYS A 1 140 ? 21.808 -15.929 -33.947 1.00 28.11  ? 121 LYS A CG  1 
ATOM   991  C CD  . LYS A 1 140 ? 21.441 -14.912 -34.960 1.00 30.21  ? 121 LYS A CD  1 
ATOM   992  C CE  . LYS A 1 140 ? 22.449 -13.787 -35.009 1.00 31.58  ? 121 LYS A CE  1 
ATOM   993  N NZ  . LYS A 1 140 ? 22.297 -12.903 -33.845 1.00 32.87  ? 121 LYS A NZ  1 
ATOM   994  N N   . LEU A 1 141 ? 21.779 -17.799 -30.743 1.00 24.83  ? 122 LEU A N   1 
ATOM   995  C CA  . LEU A 1 141 ? 21.395 -17.337 -29.396 1.00 27.39  ? 122 LEU A CA  1 
ATOM   996  C C   . LEU A 1 141 ? 20.954 -15.867 -29.476 1.00 29.01  ? 122 LEU A C   1 
ATOM   997  O O   . LEU A 1 141 ? 21.599 -15.096 -30.196 1.00 28.86  ? 122 LEU A O   1 
ATOM   998  C CB  . LEU A 1 141 ? 22.596 -17.523 -28.471 1.00 27.55  ? 122 LEU A CB  1 
ATOM   999  C CG  . LEU A 1 141 ? 23.010 -18.980 -28.301 1.00 30.58  ? 122 LEU A CG  1 
ATOM   1000 C CD1 . LEU A 1 141 ? 24.203 -19.117 -27.374 1.00 30.63  ? 122 LEU A CD1 1 
ATOM   1001 C CD2 . LEU A 1 141 ? 21.832 -19.815 -27.818 1.00 32.38  ? 122 LEU A CD2 1 
ATOM   1002 N N   . THR A 1 142 ? 19.902 -15.496 -28.752 1.00 26.62  ? 123 THR A N   1 
ATOM   1003 C CA  . THR A 1 142 ? 19.552 -14.070 -28.489 1.00 26.94  ? 123 THR A CA  1 
ATOM   1004 C C   . THR A 1 142 ? 20.491 -13.503 -27.414 1.00 27.72  ? 123 THR A C   1 
ATOM   1005 O O   . THR A 1 142 ? 21.174 -14.314 -26.720 1.00 26.32  ? 123 THR A O   1 
ATOM   1006 C CB  . THR A 1 142 ? 18.082 -13.958 -28.090 1.00 29.90  ? 123 THR A CB  1 
ATOM   1007 O OG1 . THR A 1 142 ? 17.918 -14.633 -26.834 1.00 28.70  ? 123 THR A OG1 1 
ATOM   1008 C CG2 . THR A 1 142 ? 17.174 -14.553 -29.156 1.00 27.08  ? 123 THR A CG2 1 
ATOM   1009 N N   . ASP A 1 143 ? 20.551 -12.176 -27.284 1.00 27.16  ? 124 ASP A N   1 
ATOM   1010 C CA  . ASP A 1 143 ? 21.242 -11.493 -26.159 1.00 30.84  ? 124 ASP A CA  1 
ATOM   1011 C C   . ASP A 1 143 ? 20.697 -12.052 -24.833 1.00 26.54  ? 124 ASP A C   1 
ATOM   1012 O O   . ASP A 1 143 ? 21.468 -12.194 -23.911 1.00 26.73  ? 124 ASP A O   1 
ATOM   1013 C CB  . ASP A 1 143 ? 21.144 -9.958  -26.203 1.00 33.69  ? 124 ASP A CB  1 
ATOM   1014 C CG  . ASP A 1 143 ? 22.142 -9.277  -25.245 1.00 38.43  ? 124 ASP A CG  1 
ATOM   1015 O OD1 . ASP A 1 143 ? 23.402 -9.523  -25.360 1.00 39.70  ? 124 ASP A OD1 1 
ATOM   1016 O OD2 . ASP A 1 143 ? 21.676 -8.540  -24.348 1.00 38.65  ? 124 ASP A OD2 1 
ATOM   1017 N N   . ASP A 1 144 ? 19.419 -12.370 -24.748 1.00 27.19  ? 125 ASP A N   1 
ATOM   1018 C CA  . ASP A 1 144 ? 18.804 -12.935 -23.519 1.00 28.52  ? 125 ASP A CA  1 
ATOM   1019 C C   . ASP A 1 144 ? 19.411 -14.323 -23.215 1.00 28.21  ? 125 ASP A C   1 
ATOM   1020 O O   . ASP A 1 144 ? 19.807 -14.556 -22.074 1.00 27.38  ? 125 ASP A O   1 
ATOM   1021 C CB  . ASP A 1 144 ? 17.288 -12.989 -23.662 1.00 32.19  ? 125 ASP A CB  1 
ATOM   1022 C CG  . ASP A 1 144 ? 16.638 -13.541 -22.404 1.00 41.53  ? 125 ASP A CG  1 
ATOM   1023 O OD1 . ASP A 1 144 ? 16.898 -12.969 -21.299 1.00 43.33  ? 125 ASP A OD1 1 
ATOM   1024 O OD2 . ASP A 1 144 ? 15.941 -14.577 -22.510 1.00 49.19  ? 125 ASP A OD2 1 
ATOM   1025 N N   . HIS A 1 145 ? 19.513 -15.209 -24.209 1.00 26.10  ? 126 HIS A N   1 
ATOM   1026 C CA  . HIS A 1 145 ? 20.199 -16.518 -24.072 1.00 26.79  ? 126 HIS A CA  1 
ATOM   1027 C C   . HIS A 1 145 ? 21.610 -16.287 -23.546 1.00 25.31  ? 126 HIS A C   1 
ATOM   1028 O O   . HIS A 1 145 ? 22.012 -16.987 -22.615 1.00 23.54  ? 126 HIS A O   1 
ATOM   1029 C CB  . HIS A 1 145 ? 20.273 -17.280 -25.393 1.00 30.42  ? 126 HIS A CB  1 
ATOM   1030 C CG  . HIS A 1 145 ? 18.965 -17.811 -25.852 1.00 32.63  ? 126 HIS A CG  1 
ATOM   1031 N ND1 . HIS A 1 145 ? 18.543 -17.697 -27.160 1.00 30.98  ? 126 HIS A ND1 1 
ATOM   1032 C CD2 . HIS A 1 145 ? 17.974 -18.433 -25.180 1.00 34.33  ? 126 HIS A CD2 1 
ATOM   1033 C CE1 . HIS A 1 145 ? 17.361 -18.253 -27.287 1.00 29.08  ? 126 HIS A CE1 1 
ATOM   1034 N NE2 . HIS A 1 145 ? 16.982 -18.710 -26.091 1.00 33.19  ? 126 HIS A NE2 1 
ATOM   1035 N N   . VAL A 1 146 ? 22.321 -15.296 -24.076 1.00 24.06  ? 127 VAL A N   1 
ATOM   1036 C CA  . VAL A 1 146 ? 23.745 -15.115 -23.695 1.00 23.93  ? 127 VAL A CA  1 
ATOM   1037 C C   . VAL A 1 146 ? 23.810 -14.622 -22.252 1.00 24.34  ? 127 VAL A C   1 
ATOM   1038 O O   . VAL A 1 146 ? 24.587 -15.201 -21.486 1.00 24.10  ? 127 VAL A O   1 
ATOM   1039 C CB  . VAL A 1 146 ? 24.488 -14.215 -24.688 1.00 23.08  ? 127 VAL A CB  1 
ATOM   1040 C CG1 . VAL A 1 146 ? 25.904 -13.967 -24.238 1.00 22.20  ? 127 VAL A CG1 1 
ATOM   1041 C CG2 . VAL A 1 146 ? 24.446 -14.830 -26.085 1.00 25.02  ? 127 VAL A CG2 1 
ATOM   1042 N N   . GLN A 1 147 ? 22.995 -13.638 -21.888 1.00 22.65  ? 128 GLN A N   1 
ATOM   1043 C CA  . GLN A 1 147 ? 22.895 -13.154 -20.485 1.00 24.58  ? 128 GLN A CA  1 
ATOM   1044 C C   . GLN A 1 147 ? 22.659 -14.341 -19.550 1.00 23.18  ? 128 GLN A C   1 
ATOM   1045 O O   . GLN A 1 147 ? 23.396 -14.447 -18.557 1.00 20.44  ? 128 GLN A O   1 
ATOM   1046 C CB  . GLN A 1 147 ? 21.740 -12.183 -20.237 1.00 26.70  ? 128 GLN A CB  1 
ATOM   1047 C CG  . GLN A 1 147 ? 21.930 -10.829 -20.893 1.00 28.94  ? 128 GLN A CG  1 
ATOM   1048 C CD  . GLN A 1 147 ? 20.698 -9.956  -20.798 1.00 31.77  ? 128 GLN A CD  1 
ATOM   1049 O OE1 . GLN A 1 147 ? 19.852 -10.125 -19.922 1.00 33.36  ? 128 GLN A OE1 1 
ATOM   1050 N NE2 . GLN A 1 147 ? 20.576 -9.029  -21.735 1.00 33.22  ? 128 GLN A NE2 1 
ATOM   1051 N N   . PHE A 1 148 ? 21.650 -15.162 -19.831 1.00 20.40  ? 129 PHE A N   1 
ATOM   1052 C CA  . PHE A 1 148 ? 21.257 -16.283 -18.943 1.00 21.19  ? 129 PHE A CA  1 
ATOM   1053 C C   . PHE A 1 148 ? 22.365 -17.355 -18.885 1.00 21.64  ? 129 PHE A C   1 
ATOM   1054 O O   . PHE A 1 148 ? 22.648 -17.900 -17.807 1.00 22.06  ? 129 PHE A O   1 
ATOM   1055 C CB  . PHE A 1 148 ? 19.927 -16.858 -19.415 1.00 21.75  ? 129 PHE A CB  1 
ATOM   1056 C CG  . PHE A 1 148 ? 19.326 -17.892 -18.516 1.00 22.58  ? 129 PHE A CG  1 
ATOM   1057 C CD1 . PHE A 1 148 ? 19.249 -17.694 -17.146 1.00 24.25  ? 129 PHE A CD1 1 
ATOM   1058 C CD2 . PHE A 1 148 ? 18.793 -19.051 -19.054 1.00 25.10  ? 129 PHE A CD2 1 
ATOM   1059 C CE1 . PHE A 1 148 ? 18.669 -18.654 -16.331 1.00 24.66  ? 129 PHE A CE1 1 
ATOM   1060 C CE2 . PHE A 1 148 ? 18.199 -20.006 -18.242 1.00 26.36  ? 129 PHE A CE2 1 
ATOM   1061 C CZ  . PHE A 1 148 ? 18.138 -19.808 -16.879 1.00 24.35  ? 129 PHE A CZ  1 
ATOM   1062 N N   . LEU A 1 149 ? 22.963 -17.705 -20.019 1.00 20.89  ? 130 LEU A N   1 
ATOM   1063 C CA  . LEU A 1 149 ? 24.053 -18.706 -20.051 1.00 20.90  ? 130 LEU A CA  1 
ATOM   1064 C C   . LEU A 1 149 ? 25.220 -18.175 -19.209 1.00 21.45  ? 130 LEU A C   1 
ATOM   1065 O O   . LEU A 1 149 ? 25.654 -18.883 -18.294 1.00 18.63  ? 130 LEU A O   1 
ATOM   1066 C CB  . LEU A 1 149 ? 24.442 -19.030 -21.498 1.00 20.65  ? 130 LEU A CB  1 
ATOM   1067 C CG  . LEU A 1 149 ? 23.374 -19.803 -22.270 1.00 21.02  ? 130 LEU A CG  1 
ATOM   1068 C CD1 . LEU A 1 149 ? 23.674 -19.837 -23.753 1.00 22.12  ? 130 LEU A CD1 1 
ATOM   1069 C CD2 . LEU A 1 149 ? 23.221 -21.216 -21.744 1.00 23.42  ? 130 LEU A CD2 1 
ATOM   1070 N N   . ILE A 1 150 ? 25.680 -16.953 -19.464 1.00 21.21  ? 131 ILE A N   1 
ATOM   1071 C CA  . ILE A 1 150 ? 26.858 -16.437 -18.725 1.00 21.98  ? 131 ILE A CA  1 
ATOM   1072 C C   . ILE A 1 150 ? 26.462 -16.260 -17.252 1.00 23.42  ? 131 ILE A C   1 
ATOM   1073 O O   . ILE A 1 150 ? 27.285 -16.607 -16.393 1.00 23.81  ? 131 ILE A O   1 
ATOM   1074 C CB  . ILE A 1 150 ? 27.434 -15.175 -19.392 1.00 20.50  ? 131 ILE A CB  1 
ATOM   1075 C CG1 . ILE A 1 150 ? 27.829 -15.427 -20.850 1.00 20.34  ? 131 ILE A CG1 1 
ATOM   1076 C CG2 . ILE A 1 150 ? 28.587 -14.635 -18.594 1.00 21.84  ? 131 ILE A CG2 1 
ATOM   1077 C CD1 . ILE A 1 150 ? 28.753 -16.622 -21.089 1.00 21.91  ? 131 ILE A CD1 1 
ATOM   1078 N N   . TYR A 1 151 ? 25.230 -15.833 -16.963 1.00 21.73  ? 132 TYR A N   1 
ATOM   1079 C CA  . TYR A 1 151 ? 24.756 -15.663 -15.571 1.00 22.45  ? 132 TYR A CA  1 
ATOM   1080 C C   . TYR A 1 151 ? 24.957 -16.984 -14.807 1.00 21.63  ? 132 TYR A C   1 
ATOM   1081 O O   . TYR A 1 151 ? 25.581 -16.978 -13.740 1.00 18.05  ? 132 TYR A O   1 
ATOM   1082 C CB  . TYR A 1 151 ? 23.299 -15.196 -15.532 1.00 22.65  ? 132 TYR A CB  1 
ATOM   1083 C CG  . TYR A 1 151 ? 22.750 -15.160 -14.135 1.00 21.28  ? 132 TYR A CG  1 
ATOM   1084 C CD1 . TYR A 1 151 ? 23.147 -14.179 -13.245 1.00 22.05  ? 132 TYR A CD1 1 
ATOM   1085 C CD2 . TYR A 1 151 ? 21.912 -16.156 -13.671 1.00 21.78  ? 132 TYR A CD2 1 
ATOM   1086 C CE1 . TYR A 1 151 ? 22.685 -14.165 -11.934 1.00 22.87  ? 132 TYR A CE1 1 
ATOM   1087 C CE2 . TYR A 1 151 ? 21.435 -16.158 -12.365 1.00 21.91  ? 132 TYR A CE2 1 
ATOM   1088 C CZ  . TYR A 1 151 ? 21.836 -15.169 -11.490 1.00 23.67  ? 132 TYR A CZ  1 
ATOM   1089 O OH  . TYR A 1 151 ? 21.419 -15.202 -10.192 1.00 25.65  ? 132 TYR A OH  1 
ATOM   1090 N N   . GLN A 1 152 ? 24.514 -18.096 -15.394 1.00 21.42  ? 133 GLN A N   1 
ATOM   1091 C CA  . GLN A 1 152 ? 24.535 -19.416 -14.720 1.00 23.45  ? 133 GLN A CA  1 
ATOM   1092 C C   . GLN A 1 152 ? 25.979 -19.867 -14.554 1.00 23.11  ? 133 GLN A C   1 
ATOM   1093 O O   . GLN A 1 152 ? 26.275 -20.420 -13.501 1.00 23.14  ? 133 GLN A O   1 
ATOM   1094 C CB  . GLN A 1 152 ? 23.713 -20.454 -15.478 1.00 22.34  ? 133 GLN A CB  1 
ATOM   1095 C CG  . GLN A 1 152 ? 22.235 -20.101 -15.506 1.00 20.06  ? 133 GLN A CG  1 
ATOM   1096 C CD  . GLN A 1 152 ? 21.512 -21.075 -16.383 1.00 20.07  ? 133 GLN A CD  1 
ATOM   1097 O OE1 . GLN A 1 152 ? 21.184 -22.171 -15.939 1.00 21.62  ? 133 GLN A OE1 1 
ATOM   1098 N NE2 . GLN A 1 152 ? 21.387 -20.747 -17.668 1.00 21.00  ? 133 GLN A NE2 1 
ATOM   1099 N N   . ILE A 1 153 ? 26.852 -19.600 -15.534 1.00 22.48  ? 134 ILE A N   1 
ATOM   1100 C CA  . ILE A 1 153 ? 28.279 -19.984 -15.384 1.00 20.20  ? 134 ILE A CA  1 
ATOM   1101 C C   . ILE A 1 153 ? 28.797 -19.262 -14.143 1.00 22.16  ? 134 ILE A C   1 
ATOM   1102 O O   . ILE A 1 153 ? 29.422 -19.936 -13.306 1.00 20.64  ? 134 ILE A O   1 
ATOM   1103 C CB  . ILE A 1 153 ? 29.149 -19.683 -16.605 1.00 18.63  ? 134 ILE A CB  1 
ATOM   1104 C CG1 . ILE A 1 153 ? 28.635 -20.389 -17.860 1.00 19.61  ? 134 ILE A CG1 1 
ATOM   1105 C CG2 . ILE A 1 153 ? 30.575 -20.073 -16.279 1.00 19.00  ? 134 ILE A CG2 1 
ATOM   1106 C CD1 . ILE A 1 153 ? 29.366 -20.016 -19.121 1.00 20.11  ? 134 ILE A CD1 1 
ATOM   1107 N N   . LEU A 1 154 ? 28.547 -17.956 -14.049 1.00 21.31  ? 135 LEU A N   1 
ATOM   1108 C CA  . LEU A 1 154 ? 29.105 -17.097 -12.975 1.00 23.44  ? 135 LEU A CA  1 
ATOM   1109 C C   . LEU A 1 154 ? 28.489 -17.479 -11.632 1.00 21.90  ? 135 LEU A C   1 
ATOM   1110 O O   . LEU A 1 154 ? 29.206 -17.449 -10.633 1.00 21.76  ? 135 LEU A O   1 
ATOM   1111 C CB  . LEU A 1 154 ? 28.880 -15.619 -13.309 1.00 22.59  ? 135 LEU A CB  1 
ATOM   1112 C CG  . LEU A 1 154 ? 29.744 -15.105 -14.461 1.00 25.79  ? 135 LEU A CG  1 
ATOM   1113 C CD1 . LEU A 1 154 ? 29.284 -13.736 -14.944 1.00 28.27  ? 135 LEU A CD1 1 
ATOM   1114 C CD2 . LEU A 1 154 ? 31.206 -15.055 -14.079 1.00 26.54  ? 135 LEU A CD2 1 
ATOM   1115 N N   . ARG A 1 155 ? 27.229 -17.877 -11.639 1.00 21.61  ? 136 ARG A N   1 
ATOM   1116 C CA  . ARG A 1 155 ? 26.533 -18.334 -10.427 1.00 22.05  ? 136 ARG A CA  1 
ATOM   1117 C C   . ARG A 1 155 ? 27.198 -19.629 -9.919  1.00 21.97  ? 136 ARG A C   1 
ATOM   1118 O O   . ARG A 1 155 ? 27.524 -19.697 -8.725  1.00 20.05  ? 136 ARG A O   1 
ATOM   1119 C CB  . ARG A 1 155 ? 25.052 -18.483 -10.746 1.00 23.24  ? 136 ARG A CB  1 
ATOM   1120 C CG  . ARG A 1 155 ? 24.196 -18.695 -9.514  1.00 24.38  ? 136 ARG A CG  1 
ATOM   1121 C CD  . ARG A 1 155 ? 22.741 -18.677 -9.920  1.00 28.25  ? 136 ARG A CD  1 
ATOM   1122 N NE  . ARG A 1 155 ? 21.856 -18.988 -8.823  1.00 28.88  ? 136 ARG A NE  1 
ATOM   1123 C CZ  . ARG A 1 155 ? 21.324 -20.179 -8.594  1.00 33.62  ? 136 ARG A CZ  1 
ATOM   1124 N NH1 . ARG A 1 155 ? 21.594 -21.208 -9.387  1.00 34.41  ? 136 ARG A NH1 1 
ATOM   1125 N NH2 . ARG A 1 155 ? 20.523 -20.330 -7.553  1.00 33.54  ? 136 ARG A NH2 1 
ATOM   1126 N N   . GLY A 1 156 ? 27.423 -20.611 -10.787 1.00 22.08  ? 137 GLY A N   1 
ATOM   1127 C CA  . GLY A 1 156 ? 28.221 -21.807 -10.443 1.00 22.31  ? 137 GLY A CA  1 
ATOM   1128 C C   . GLY A 1 156 ? 29.618 -21.425 -9.951  1.00 21.99  ? 137 GLY A C   1 
ATOM   1129 O O   . GLY A 1 156 ? 30.070 -21.982 -8.950  1.00 23.59  ? 137 GLY A O   1 
ATOM   1130 N N   . LEU A 1 157 ? 30.290 -20.475 -10.592 1.00 21.05  ? 138 LEU A N   1 
ATOM   1131 C CA  . LEU A 1 157 ? 31.685 -20.144 -10.245 1.00 22.15  ? 138 LEU A CA  1 
ATOM   1132 C C   . LEU A 1 157 ? 31.705 -19.458 -8.890  1.00 24.42  ? 138 LEU A C   1 
ATOM   1133 O O   . LEU A 1 157 ? 32.644 -19.697 -8.143  1.00 27.11  ? 138 LEU A O   1 
ATOM   1134 C CB  . LEU A 1 157 ? 32.308 -19.266 -11.327 1.00 23.70  ? 138 LEU A CB  1 
ATOM   1135 C CG  . LEU A 1 157 ? 32.751 -20.039 -12.557 1.00 25.64  ? 138 LEU A CG  1 
ATOM   1136 C CD1 . LEU A 1 157 ? 33.359 -19.101 -13.596 1.00 26.88  ? 138 LEU A CD1 1 
ATOM   1137 C CD2 . LEU A 1 157 ? 33.715 -21.138 -12.130 1.00 25.89  ? 138 LEU A CD2 1 
ATOM   1138 N N   . LYS A 1 158 ? 30.697 -18.643 -8.582  1.00 24.10  ? 139 LYS A N   1 
ATOM   1139 C CA  . LYS A 1 158 ? 30.663 -17.982 -7.266  1.00 24.17  ? 139 LYS A CA  1 
ATOM   1140 C C   . LYS A 1 158 ? 30.700 -19.074 -6.182  1.00 24.61  ? 139 LYS A C   1 
ATOM   1141 O O   . LYS A 1 158 ? 31.492 -18.945 -5.215  1.00 23.23  ? 139 LYS A O   1 
ATOM   1142 C CB  . LYS A 1 158 ? 29.425 -17.104 -7.128  1.00 23.54  ? 139 LYS A CB  1 
ATOM   1143 C CG  . LYS A 1 158 ? 29.408 -16.334 -5.823  1.00 25.34  ? 139 LYS A CG  1 
ATOM   1144 C CD  . LYS A 1 158 ? 28.043 -15.916 -5.375  1.00 26.16  ? 139 LYS A CD  1 
ATOM   1145 C CE  . LYS A 1 158 ? 28.092 -15.238 -4.028  1.00 24.41  ? 139 LYS A CE  1 
ATOM   1146 N NZ  . LYS A 1 158 ? 26.792 -14.619 -3.719  1.00 26.17  ? 139 LYS A NZ  1 
ATOM   1147 N N   . TYR A 1 159 ? 29.842 -20.081 -6.339  1.00 22.62  ? 140 TYR A N   1 
ATOM   1148 C CA  . TYR A 1 159 ? 29.747 -21.266 -5.463  1.00 24.09  ? 140 TYR A CA  1 
ATOM   1149 C C   . TYR A 1 159 ? 31.115 -21.962 -5.367  1.00 26.22  ? 140 TYR A C   1 
ATOM   1150 O O   . TYR A 1 159 ? 31.611 -22.026 -4.233  1.00 25.75  ? 140 TYR A O   1 
ATOM   1151 C CB  . TYR A 1 159 ? 28.658 -22.226 -5.937  1.00 24.53  ? 140 TYR A CB  1 
ATOM   1152 C CG  . TYR A 1 159 ? 28.535 -23.477 -5.097  1.00 24.34  ? 140 TYR A CG  1 
ATOM   1153 C CD1 . TYR A 1 159 ? 27.776 -23.491 -3.931  1.00 25.05  ? 140 TYR A CD1 1 
ATOM   1154 C CD2 . TYR A 1 159 ? 29.159 -24.649 -5.481  1.00 24.69  ? 140 TYR A CD2 1 
ATOM   1155 C CE1 . TYR A 1 159 ? 27.650 -24.633 -3.167  1.00 25.81  ? 140 TYR A CE1 1 
ATOM   1156 C CE2 . TYR A 1 159 ? 29.057 -25.800 -4.722  1.00 27.28  ? 140 TYR A CE2 1 
ATOM   1157 C CZ  . TYR A 1 159 ? 28.301 -25.797 -3.561  1.00 28.31  ? 140 TYR A CZ  1 
ATOM   1158 O OH  . TYR A 1 159 ? 28.192 -26.959 -2.837  1.00 28.73  ? 140 TYR A OH  1 
ATOM   1159 N N   . ILE A 1 160 ? 31.696 -22.464 -6.467  1.00 24.05  ? 141 ILE A N   1 
ATOM   1160 C CA  . ILE A 1 160 ? 32.958 -23.259 -6.369  1.00 27.91  ? 141 ILE A CA  1 
ATOM   1161 C C   . ILE A 1 160 ? 34.101 -22.379 -5.841  1.00 26.18  ? 141 ILE A C   1 
ATOM   1162 O O   . ILE A 1 160 ? 34.832 -22.848 -4.971  1.00 23.97  ? 141 ILE A O   1 
ATOM   1163 C CB  . ILE A 1 160 ? 33.339 -23.992 -7.666  1.00 31.20  ? 141 ILE A CB  1 
ATOM   1164 C CG1 . ILE A 1 160 ? 33.679 -23.046 -8.809  1.00 36.95  ? 141 ILE A CG1 1 
ATOM   1165 C CG2 . ILE A 1 160 ? 32.252 -24.974 -8.089  1.00 32.25  ? 141 ILE A CG2 1 
ATOM   1166 C CD1 . ILE A 1 160 ? 34.466 -23.752 -9.890  1.00 41.23  ? 141 ILE A CD1 1 
ATOM   1167 N N   . HIS A 1 161 ? 34.226 -21.139 -6.298  1.00 25.28  ? 142 HIS A N   1 
ATOM   1168 C CA  . HIS A 1 161 ? 35.330 -20.244 -5.884  1.00 25.16  ? 142 HIS A CA  1 
ATOM   1169 C C   . HIS A 1 161 ? 35.208 -19.978 -4.388  1.00 25.60  ? 142 HIS A C   1 
ATOM   1170 O O   . HIS A 1 161 ? 36.240 -19.808 -3.760  1.00 25.61  ? 142 HIS A O   1 
ATOM   1171 C CB  . HIS A 1 161 ? 35.348 -18.959 -6.724  1.00 26.42  ? 142 HIS A CB  1 
ATOM   1172 C CG  . HIS A 1 161 ? 35.821 -19.170 -8.123  1.00 27.63  ? 142 HIS A CG  1 
ATOM   1173 N ND1 . HIS A 1 161 ? 35.852 -18.150 -9.049  1.00 26.05  ? 142 HIS A ND1 1 
ATOM   1174 C CD2 . HIS A 1 161 ? 36.285 -20.277 -8.757  1.00 27.45  ? 142 HIS A CD2 1 
ATOM   1175 C CE1 . HIS A 1 161 ? 36.329 -18.620 -10.191 1.00 26.51  ? 142 HIS A CE1 1 
ATOM   1176 N NE2 . HIS A 1 161 ? 36.600 -19.915 -10.043 1.00 26.64  ? 142 HIS A NE2 1 
ATOM   1177 N N   . SER A 1 162 ? 33.987 -19.920 -3.847  1.00 27.64  ? 143 SER A N   1 
ATOM   1178 C CA  . SER A 1 162 ? 33.756 -19.667 -2.404  1.00 27.70  ? 143 SER A CA  1 
ATOM   1179 C C   . SER A 1 162 ? 34.308 -20.830 -1.565  1.00 29.01  ? 143 SER A C   1 
ATOM   1180 O O   . SER A 1 162 ? 34.591 -20.573 -0.380  1.00 31.77  ? 143 SER A O   1 
ATOM   1181 C CB  . SER A 1 162 ? 32.319 -19.428 -2.085  1.00 26.90  ? 143 SER A CB  1 
ATOM   1182 O OG  . SER A 1 162 ? 31.591 -20.625 -2.220  1.00 27.45  ? 143 SER A OG  1 
ATOM   1183 N N   . ALA A 1 163 ? 34.417 -22.039 -2.126  1.00 28.57  ? 144 ALA A N   1 
ATOM   1184 C CA  . ALA A 1 163 ? 35.076 -23.209 -1.476  1.00 32.58  ? 144 ALA A CA  1 
ATOM   1185 C C   . ALA A 1 163 ? 36.565 -23.311 -1.871  1.00 31.50  ? 144 ALA A C   1 
ATOM   1186 O O   . ALA A 1 163 ? 37.179 -24.373 -1.623  1.00 33.93  ? 144 ALA A O   1 
ATOM   1187 C CB  . ALA A 1 163 ? 34.345 -24.481 -1.846  1.00 30.44  ? 144 ALA A CB  1 
ATOM   1188 N N   . ASP A 1 164 ? 37.128 -22.298 -2.530  1.00 29.59  ? 145 ASP A N   1 
ATOM   1189 C CA  . ASP A 1 164 ? 38.530 -22.318 -3.027  1.00 31.25  ? 145 ASP A CA  1 
ATOM   1190 C C   . ASP A 1 164 ? 38.725 -23.525 -3.913  1.00 29.22  ? 145 ASP A C   1 
ATOM   1191 O O   . ASP A 1 164 ? 39.783 -24.147 -3.852  1.00 29.95  ? 145 ASP A O   1 
ATOM   1192 C CB  . ASP A 1 164 ? 39.537 -22.325 -1.876  1.00 38.44  ? 145 ASP A CB  1 
ATOM   1193 C CG  . ASP A 1 164 ? 39.418 -21.062 -1.053  1.00 46.46  ? 145 ASP A CG  1 
ATOM   1194 O OD1 . ASP A 1 164 ? 39.440 -19.961 -1.675  1.00 49.18  ? 145 ASP A OD1 1 
ATOM   1195 O OD2 . ASP A 1 164 ? 39.241 -21.182 0.175   1.00 58.23  ? 145 ASP A OD2 1 
ATOM   1196 N N   . ILE A 1 165 ? 37.713 -23.841 -4.702  1.00 29.68  ? 146 ILE A N   1 
ATOM   1197 C CA  . ILE A 1 165 ? 37.840 -24.801 -5.823  1.00 30.37  ? 146 ILE A CA  1 
ATOM   1198 C C   . ILE A 1 165 ? 38.046 -23.968 -7.093  1.00 34.39  ? 146 ILE A C   1 
ATOM   1199 O O   . ILE A 1 165 ? 37.327 -22.950 -7.286  1.00 28.19  ? 146 ILE A O   1 
ATOM   1200 C CB  . ILE A 1 165 ? 36.602 -25.718 -5.892  1.00 30.68  ? 146 ILE A CB  1 
ATOM   1201 C CG1 . ILE A 1 165 ? 36.474 -26.600 -4.643  1.00 32.32  ? 146 ILE A CG1 1 
ATOM   1202 C CG2 . ILE A 1 165 ? 36.617 -26.556 -7.160  1.00 31.08  ? 146 ILE A CG2 1 
ATOM   1203 C CD1 . ILE A 1 165 ? 35.076 -27.191 -4.447  1.00 31.68  ? 146 ILE A CD1 1 
ATOM   1204 N N   . ILE A 1 166 ? 38.982 -24.395 -7.935  1.00 31.28  ? 147 ILE A N   1 
ATOM   1205 C CA  . ILE A 1 166 ? 39.226 -23.770 -9.250  1.00 29.82  ? 147 ILE A CA  1 
ATOM   1206 C C   . ILE A 1 166 ? 38.917 -24.839 -10.281 1.00 29.87  ? 147 ILE A C   1 
ATOM   1207 O O   . ILE A 1 166 ? 39.446 -25.942 -10.141 1.00 28.23  ? 147 ILE A O   1 
ATOM   1208 C CB  . ILE A 1 166 ? 40.668 -23.253 -9.335  1.00 33.72  ? 147 ILE A CB  1 
ATOM   1209 C CG1 . ILE A 1 166 ? 41.008 -22.370 -8.130  1.00 36.93  ? 147 ILE A CG1 1 
ATOM   1210 C CG2 . ILE A 1 166 ? 40.902 -22.541 -10.659 1.00 32.61  ? 147 ILE A CG2 1 
ATOM   1211 C CD1 . ILE A 1 166 ? 42.480 -21.993 -8.041  1.00 39.32  ? 147 ILE A CD1 1 
ATOM   1212 N N   . HIS A 1 167 ? 38.089 -24.533 -11.273 1.00 27.51  ? 148 HIS A N   1 
ATOM   1213 C CA  . HIS A 1 167 ? 37.760 -25.510 -12.341 1.00 28.38  ? 148 HIS A CA  1 
ATOM   1214 C C   . HIS A 1 167 ? 39.009 -25.826 -13.162 1.00 29.81  ? 148 HIS A C   1 
ATOM   1215 O O   . HIS A 1 167 ? 39.262 -27.021 -13.394 1.00 32.91  ? 148 HIS A O   1 
ATOM   1216 C CB  . HIS A 1 167 ? 36.656 -24.996 -13.244 1.00 25.96  ? 148 HIS A CB  1 
ATOM   1217 C CG  . HIS A 1 167 ? 36.171 -26.036 -14.177 1.00 22.88  ? 148 HIS A CG  1 
ATOM   1218 N ND1 . HIS A 1 167 ? 36.870 -26.364 -15.318 1.00 23.00  ? 148 HIS A ND1 1 
ATOM   1219 C CD2 . HIS A 1 167 ? 35.060 -26.802 -14.142 1.00 22.61  ? 148 HIS A CD2 1 
ATOM   1220 C CE1 . HIS A 1 167 ? 36.208 -27.310 -15.967 1.00 24.11  ? 148 HIS A CE1 1 
ATOM   1221 N NE2 . HIS A 1 167 ? 35.087 -27.616 -15.247 1.00 24.89  ? 148 HIS A NE2 1 
ATOM   1222 N N   . ARG A 1 168 ? 39.690 -24.778 -13.624 1.00 30.51  ? 149 ARG A N   1 
ATOM   1223 C CA  . ARG A 1 168 ? 40.986 -24.812 -14.354 1.00 34.82  ? 149 ARG A CA  1 
ATOM   1224 C C   . ARG A 1 168 ? 40.788 -25.064 -15.855 1.00 33.73  ? 149 ARG A C   1 
ATOM   1225 O O   . ARG A 1 168 ? 41.730 -24.769 -16.614 1.00 30.76  ? 149 ARG A O   1 
ATOM   1226 C CB  . ARG A 1 168 ? 41.922 -25.884 -13.803 1.00 38.03  ? 149 ARG A CB  1 
ATOM   1227 C CG  . ARG A 1 168 ? 42.386 -25.652 -12.372 1.00 47.94  ? 149 ARG A CG  1 
ATOM   1228 C CD  . ARG A 1 168 ? 43.171 -26.854 -11.865 1.00 55.44  ? 149 ARG A CD  1 
ATOM   1229 N NE  . ARG A 1 168 ? 43.854 -26.535 -10.621 1.00 65.70  ? 149 ARG A NE  1 
ATOM   1230 C CZ  . ARG A 1 168 ? 43.317 -26.620 -9.411  1.00 75.33  ? 149 ARG A CZ  1 
ATOM   1231 N NH1 . ARG A 1 168 ? 42.073 -27.053 -9.260  1.00 80.45  ? 149 ARG A NH1 1 
ATOM   1232 N NH2 . ARG A 1 168 ? 44.038 -26.286 -8.354  1.00 72.40  ? 149 ARG A NH2 1 
ATOM   1233 N N   . ASP A 1 169 ? 39.648 -25.609 -16.290 1.00 30.56  ? 150 ASP A N   1 
ATOM   1234 C CA  . ASP A 1 169 ? 39.500 -25.955 -17.723 1.00 30.37  ? 150 ASP A CA  1 
ATOM   1235 C C   . ASP A 1 169 ? 38.089 -25.648 -18.230 1.00 29.49  ? 150 ASP A C   1 
ATOM   1236 O O   . ASP A 1 169 ? 37.540 -26.480 -18.967 1.00 29.20  ? 150 ASP A O   1 
ATOM   1237 C CB  . ASP A 1 169 ? 39.946 -27.394 -17.945 1.00 35.40  ? 150 ASP A CB  1 
ATOM   1238 C CG  . ASP A 1 169 ? 40.122 -27.779 -19.408 1.00 35.36  ? 150 ASP A CG  1 
ATOM   1239 O OD1 . ASP A 1 169 ? 40.615 -26.936 -20.211 1.00 34.46  ? 150 ASP A OD1 1 
ATOM   1240 O OD2 . ASP A 1 169 ? 39.706 -28.901 -19.733 1.00 42.77  ? 150 ASP A OD2 1 
ATOM   1241 N N   . LEU A 1 170 ? 37.583 -24.439 -17.958 1.00 26.39  ? 151 LEU A N   1 
ATOM   1242 C CA  . LEU A 1 170 ? 36.281 -23.979 -18.475 1.00 24.37  ? 151 LEU A CA  1 
ATOM   1243 C C   . LEU A 1 170 ? 36.380 -23.824 -19.984 1.00 24.38  ? 151 LEU A C   1 
ATOM   1244 O O   . LEU A 1 170 ? 37.321 -23.172 -20.443 1.00 22.04  ? 151 LEU A O   1 
ATOM   1245 C CB  . LEU A 1 170 ? 35.892 -22.653 -17.837 1.00 25.19  ? 151 LEU A CB  1 
ATOM   1246 C CG  . LEU A 1 170 ? 35.298 -22.769 -16.448 1.00 28.47  ? 151 LEU A CG  1 
ATOM   1247 C CD1 . LEU A 1 170 ? 34.976 -21.385 -15.922 1.00 29.05  ? 151 LEU A CD1 1 
ATOM   1248 C CD2 . LEU A 1 170 ? 34.062 -23.680 -16.447 1.00 30.27  ? 151 LEU A CD2 1 
ATOM   1249 N N   . LYS A 1 171 ? 35.414 -24.379 -20.710 1.00 23.01  ? 152 LYS A N   1 
ATOM   1250 C CA  . LYS A 1 171 ? 35.336 -24.253 -22.173 1.00 22.69  ? 152 LYS A CA  1 
ATOM   1251 C C   . LYS A 1 171 ? 33.990 -24.790 -22.583 1.00 22.96  ? 152 LYS A C   1 
ATOM   1252 O O   . LYS A 1 171 ? 33.344 -25.432 -21.768 1.00 22.23  ? 152 LYS A O   1 
ATOM   1253 C CB  . LYS A 1 171 ? 36.485 -25.007 -22.829 1.00 24.26  ? 152 LYS A CB  1 
ATOM   1254 C CG  . LYS A 1 171 ? 36.622 -26.460 -22.455 1.00 28.49  ? 152 LYS A CG  1 
ATOM   1255 C CD  . LYS A 1 171 ? 37.820 -27.106 -23.097 1.00 28.63  ? 152 LYS A CD  1 
ATOM   1256 C CE  . LYS A 1 171 ? 37.907 -28.557 -22.713 1.00 34.82  ? 152 LYS A CE  1 
ATOM   1257 N NZ  . LYS A 1 171 ? 39.085 -29.194 -23.337 1.00 44.39  ? 152 LYS A NZ  1 
ATOM   1258 N N   . PRO A 1 172 ? 33.486 -24.468 -23.785 1.00 20.37  ? 153 PRO A N   1 
ATOM   1259 C CA  . PRO A 1 172 ? 32.120 -24.823 -24.133 1.00 22.36  ? 153 PRO A CA  1 
ATOM   1260 C C   . PRO A 1 172 ? 31.807 -26.316 -23.992 1.00 25.79  ? 153 PRO A C   1 
ATOM   1261 O O   . PRO A 1 172 ? 30.645 -26.643 -23.678 1.00 24.65  ? 153 PRO A O   1 
ATOM   1262 C CB  . PRO A 1 172 ? 31.958 -24.361 -25.590 1.00 21.86  ? 153 PRO A CB  1 
ATOM   1263 C CG  . PRO A 1 172 ? 32.964 -23.222 -25.715 1.00 21.58  ? 153 PRO A CG  1 
ATOM   1264 C CD  . PRO A 1 172 ? 34.108 -23.581 -24.770 1.00 22.45  ? 153 PRO A CD  1 
ATOM   1265 N N   . SER A 1 173 ? 32.788 -27.188 -24.253 1.00 26.40  ? 154 SER A N   1 
ATOM   1266 C CA  . SER A 1 173 ? 32.587 -28.668 -24.233 1.00 26.96  ? 154 SER A CA  1 
ATOM   1267 C C   . SER A 1 173 ? 32.423 -29.198 -22.792 1.00 27.27  ? 154 SER A C   1 
ATOM   1268 O O   . SER A 1 173 ? 32.094 -30.384 -22.656 1.00 27.97  ? 154 SER A O   1 
ATOM   1269 C CB  . SER A 1 173 ? 33.704 -29.392 -24.966 1.00 25.84  ? 154 SER A CB  1 
ATOM   1270 O OG  . SER A 1 173 ? 34.957 -29.185 -24.334 1.00 26.80  ? 154 SER A OG  1 
ATOM   1271 N N   . ASN A 1 174 ? 32.690 -28.378 -21.772 1.00 23.93  ? 155 ASN A N   1 
ATOM   1272 C CA  . ASN A 1 174 ? 32.514 -28.736 -20.347 1.00 27.80  ? 155 ASN A CA  1 
ATOM   1273 C C   . ASN A 1 174 ? 31.300 -27.997 -19.785 1.00 26.56  ? 155 ASN A C   1 
ATOM   1274 O O   . ASN A 1 174 ? 31.192 -27.912 -18.567 1.00 27.36  ? 155 ASN A O   1 
ATOM   1275 C CB  . ASN A 1 174 ? 33.780 -28.407 -19.536 1.00 30.47  ? 155 ASN A CB  1 
ATOM   1276 C CG  . ASN A 1 174 ? 34.916 -29.373 -19.828 1.00 34.93  ? 155 ASN A CG  1 
ATOM   1277 O OD1 . ASN A 1 174 ? 34.704 -30.502 -20.289 1.00 38.47  ? 155 ASN A OD1 1 
ATOM   1278 N ND2 . ASN A 1 174 ? 36.144 -28.926 -19.636 1.00 35.99  ? 155 ASN A ND2 1 
ATOM   1279 N N   . LEU A 1 175 ? 30.432 -27.441 -20.630 1.00 25.62  ? 156 LEU A N   1 
ATOM   1280 C CA  . LEU A 1 175 ? 29.184 -26.797 -20.151 1.00 24.16  ? 156 LEU A CA  1 
ATOM   1281 C C   . LEU A 1 175 ? 27.999 -27.552 -20.736 1.00 24.68  ? 156 LEU A C   1 
ATOM   1282 O O   . LEU A 1 175 ? 27.826 -27.538 -21.968 1.00 25.57  ? 156 LEU A O   1 
ATOM   1283 C CB  . LEU A 1 175 ? 29.190 -25.317 -20.532 1.00 24.31  ? 156 LEU A CB  1 
ATOM   1284 C CG  . LEU A 1 175 ? 30.406 -24.532 -20.028 1.00 24.68  ? 156 LEU A CG  1 
ATOM   1285 C CD1 . LEU A 1 175 ? 30.381 -23.104 -20.561 1.00 26.82  ? 156 LEU A CD1 1 
ATOM   1286 C CD2 . LEU A 1 175 ? 30.484 -24.541 -18.505 1.00 25.09  ? 156 LEU A CD2 1 
ATOM   1287 N N   . ALA A 1 176 ? 27.206 -28.208 -19.879 1.00 23.89  ? 157 ALA A N   1 
ATOM   1288 C CA  . ALA A 1 176 ? 25.989 -28.931 -20.301 1.00 22.19  ? 157 ALA A CA  1 
ATOM   1289 C C   . ALA A 1 176 ? 24.864 -27.905 -20.363 1.00 21.19  ? 157 ALA A C   1 
ATOM   1290 O O   . ALA A 1 176 ? 24.788 -27.058 -19.467 1.00 20.53  ? 157 ALA A O   1 
ATOM   1291 C CB  . ALA A 1 176 ? 25.673 -30.075 -19.363 1.00 21.73  ? 157 ALA A CB  1 
ATOM   1292 N N   . VAL A 1 177 ? 24.017 -27.992 -21.374 1.00 20.11  ? 158 VAL A N   1 
ATOM   1293 C CA  . VAL A 1 177 ? 22.862 -27.073 -21.536 1.00 23.78  ? 158 VAL A CA  1 
ATOM   1294 C C   . VAL A 1 177 ? 21.664 -27.936 -21.948 1.00 24.06  ? 158 VAL A C   1 
ATOM   1295 O O   . VAL A 1 177 ? 21.838 -28.816 -22.828 1.00 27.35  ? 158 VAL A O   1 
ATOM   1296 C CB  . VAL A 1 177 ? 23.153 -25.947 -22.557 1.00 24.25  ? 158 VAL A CB  1 
ATOM   1297 C CG1 . VAL A 1 177 ? 22.001 -24.960 -22.654 1.00 25.63  ? 158 VAL A CG1 1 
ATOM   1298 C CG2 . VAL A 1 177 ? 24.443 -25.199 -22.236 1.00 25.23  ? 158 VAL A CG2 1 
ATOM   1299 N N   . ASN A 1 178 ? 20.519 -27.742 -21.303 1.00 23.24  ? 159 ASN A N   1 
ATOM   1300 C CA  . ASN A 1 178 ? 19.280 -28.483 -21.671 1.00 25.91  ? 159 ASN A CA  1 
ATOM   1301 C C   . ASN A 1 178 ? 18.418 -27.564 -22.542 1.00 27.40  ? 159 ASN A C   1 
ATOM   1302 O O   . ASN A 1 178 ? 18.839 -26.386 -22.837 1.00 26.39  ? 159 ASN A O   1 
ATOM   1303 C CB  . ASN A 1 178 ? 18.520 -29.026 -20.457 1.00 25.55  ? 159 ASN A CB  1 
ATOM   1304 C CG  . ASN A 1 178 ? 17.988 -27.941 -19.556 1.00 27.62  ? 159 ASN A CG  1 
ATOM   1305 O OD1 . ASN A 1 178 ? 17.819 -26.787 -19.981 1.00 25.11  ? 159 ASN A OD1 1 
ATOM   1306 N ND2 . ASN A 1 178 ? 17.738 -28.308 -18.303 1.00 25.95  ? 159 ASN A ND2 1 
ATOM   1307 N N   . GLU A 1 179 ? 17.239 -28.033 -22.914 1.00 27.02  ? 160 GLU A N   1 
ATOM   1308 C CA  . GLU A 1 179 ? 16.371 -27.297 -23.862 1.00 30.71  ? 160 GLU A CA  1 
ATOM   1309 C C   . GLU A 1 179 ? 15.783 -26.073 -23.163 1.00 26.73  ? 160 GLU A C   1 
ATOM   1310 O O   . GLU A 1 179 ? 15.273 -25.225 -23.873 1.00 26.36  ? 160 GLU A O   1 
ATOM   1311 C CB  . GLU A 1 179 ? 15.302 -28.229 -24.425 1.00 36.09  ? 160 GLU A CB  1 
ATOM   1312 C CG  . GLU A 1 179 ? 14.124 -28.423 -23.490 1.00 43.54  ? 160 GLU A CG  1 
ATOM   1313 C CD  . GLU A 1 179 ? 13.243 -29.592 -23.932 1.00 55.69  ? 160 GLU A CD  1 
ATOM   1314 O OE1 . GLU A 1 179 ? 13.825 -30.636 -24.397 1.00 56.32  ? 160 GLU A OE1 1 
ATOM   1315 O OE2 . GLU A 1 179 ? 11.983 -29.446 -23.866 1.00 49.85  ? 160 GLU A OE2 1 
ATOM   1316 N N   . ASP A 1 180 ? 15.813 -26.003 -21.825 1.00 23.98  ? 161 ASP A N   1 
ATOM   1317 C CA  . ASP A 1 180 ? 15.339 -24.805 -21.099 1.00 23.46  ? 161 ASP A CA  1 
ATOM   1318 C C   . ASP A 1 180 ? 16.483 -23.803 -20.956 1.00 24.69  ? 161 ASP A C   1 
ATOM   1319 O O   . ASP A 1 180 ? 16.274 -22.823 -20.231 1.00 20.52  ? 161 ASP A O   1 
ATOM   1320 C CB  . ASP A 1 180 ? 14.738 -25.191 -19.752 1.00 30.61  ? 161 ASP A CB  1 
ATOM   1321 C CG  . ASP A 1 180 ? 13.457 -25.984 -19.965 1.00 34.53  ? 161 ASP A CG  1 
ATOM   1322 O OD1 . ASP A 1 180 ? 12.709 -25.605 -20.867 1.00 33.27  ? 161 ASP A OD1 1 
ATOM   1323 O OD2 . ASP A 1 180 ? 13.273 -27.027 -19.296 1.00 40.94  ? 161 ASP A OD2 1 
ATOM   1324 N N   . CYS A 1 181 ? 17.639 -24.048 -21.617 1.00 23.69  ? 162 CYS A N   1 
ATOM   1325 C CA  . CYS A 1 181 ? 18.817 -23.149 -21.591 1.00 23.00  ? 162 CYS A CA  1 
ATOM   1326 C C   . CYS A 1 181 ? 19.393 -23.145 -20.161 1.00 22.11  ? 162 CYS A C   1 
ATOM   1327 O O   . CYS A 1 181 ? 20.030 -22.164 -19.776 1.00 22.70  ? 162 CYS A O   1 
ATOM   1328 C CB  . CYS A 1 181 ? 18.384 -21.772 -22.080 1.00 23.67  ? 162 CYS A CB  1 
ATOM   1329 S SG  . CYS A 1 181 ? 19.727 -20.621 -22.483 1.00 25.91  ? 162 CYS A SG  1 
ATOM   1330 N N   . GLU A 1 182 ? 19.152 -24.212 -19.394 1.00 22.75  ? 163 GLU A N   1 
ATOM   1331 C CA  . GLU A 1 182 ? 19.726 -24.385 -18.033 1.00 24.23  ? 163 GLU A CA  1 
ATOM   1332 C C   . GLU A 1 182 ? 21.108 -24.973 -18.212 1.00 22.87  ? 163 GLU A C   1 
ATOM   1333 O O   . GLU A 1 182 ? 21.252 -25.794 -19.089 1.00 24.73  ? 163 GLU A O   1 
ATOM   1334 C CB  . GLU A 1 182 ? 18.878 -25.268 -17.115 1.00 25.66  ? 163 GLU A CB  1 
ATOM   1335 C CG  . GLU A 1 182 ? 17.641 -24.551 -16.607 1.00 28.97  ? 163 GLU A CG  1 
ATOM   1336 C CD  . GLU A 1 182 ? 16.520 -25.422 -16.055 1.00 30.14  ? 163 GLU A CD  1 
ATOM   1337 O OE1 . GLU A 1 182 ? 16.536 -26.625 -16.284 1.00 29.15  ? 163 GLU A OE1 1 
ATOM   1338 O OE2 . GLU A 1 182 ? 15.619 -24.862 -15.408 1.00 36.18  ? 163 GLU A OE2 1 
ATOM   1339 N N   . LEU A 1 183 ? 22.074 -24.529 -17.403 1.00 22.70  ? 164 LEU A N   1 
ATOM   1340 C CA  . LEU A 1 183 ? 23.507 -24.846 -17.638 1.00 23.60  ? 164 LEU A CA  1 
ATOM   1341 C C   . LEU A 1 183 ? 24.102 -25.468 -16.379 1.00 22.08  ? 164 LEU A C   1 
ATOM   1342 O O   . LEU A 1 183 ? 23.767 -25.009 -15.259 1.00 19.46  ? 164 LEU A O   1 
ATOM   1343 C CB  . LEU A 1 183 ? 24.216 -23.551 -18.036 1.00 22.09  ? 164 LEU A CB  1 
ATOM   1344 C CG  . LEU A 1 183 ? 25.725 -23.639 -18.219 1.00 22.32  ? 164 LEU A CG  1 
ATOM   1345 C CD1 . LEU A 1 183 ? 26.189 -22.608 -19.248 1.00 23.22  ? 164 LEU A CD1 1 
ATOM   1346 C CD2 . LEU A 1 183 ? 26.455 -23.443 -16.894 1.00 20.61  ? 164 LEU A CD2 1 
ATOM   1347 N N   . LYS A 1 184 ? 24.992 -26.433 -16.576 1.00 23.54  ? 165 LYS A N   1 
ATOM   1348 C CA  . LYS A 1 184 ? 25.793 -27.027 -15.486 1.00 26.22  ? 165 LYS A CA  1 
ATOM   1349 C C   . LYS A 1 184 ? 27.265 -27.040 -15.873 1.00 24.77  ? 165 LYS A C   1 
ATOM   1350 O O   . LYS A 1 184 ? 27.578 -27.493 -16.970 1.00 22.15  ? 165 LYS A O   1 
ATOM   1351 C CB  . LYS A 1 184 ? 25.315 -28.453 -15.203 1.00 30.94  ? 165 LYS A CB  1 
ATOM   1352 C CG  . LYS A 1 184 ? 24.114 -28.544 -14.266 1.00 35.86  ? 165 LYS A CG  1 
ATOM   1353 C CD  . LYS A 1 184 ? 23.775 -29.987 -13.847 1.00 37.00  ? 165 LYS A CD  1 
ATOM   1354 C CE  . LYS A 1 184 ? 22.330 -30.134 -13.402 1.00 37.83  ? 165 LYS A CE  1 
ATOM   1355 N NZ  . LYS A 1 184 ? 22.025 -29.270 -12.238 1.00 38.15  ? 165 LYS A NZ  1 
ATOM   1356 N N   . ILE A 1 185 ? 28.130 -26.708 -14.923 1.00 22.32  ? 166 ILE A N   1 
ATOM   1357 C CA  . ILE A 1 185 ? 29.592 -26.837 -15.120 1.00 22.01  ? 166 ILE A CA  1 
ATOM   1358 C C   . ILE A 1 185 ? 29.984 -28.287 -14.860 1.00 23.12  ? 166 ILE A C   1 
ATOM   1359 O O   . ILE A 1 185 ? 29.787 -28.758 -13.752 1.00 22.83  ? 166 ILE A O   1 
ATOM   1360 C CB  . ILE A 1 185 ? 30.329 -25.863 -14.204 1.00 22.47  ? 166 ILE A CB  1 
ATOM   1361 C CG1 . ILE A 1 185 ? 29.911 -24.415 -14.494 1.00 22.54  ? 166 ILE A CG1 1 
ATOM   1362 C CG2 . ILE A 1 185 ? 31.830 -26.089 -14.301 1.00 21.06  ? 166 ILE A CG2 1 
ATOM   1363 C CD1 . ILE A 1 185 ? 30.379 -23.442 -13.451 1.00 22.17  ? 166 ILE A CD1 1 
ATOM   1364 N N   . LEU A 1 186 ? 30.581 -28.940 -15.849 1.00 23.94  ? 167 LEU A N   1 
ATOM   1365 C CA  . LEU A 1 186 ? 30.987 -30.363 -15.791 1.00 25.52  ? 167 LEU A CA  1 
ATOM   1366 C C   . LEU A 1 186 ? 32.510 -30.460 -15.862 1.00 26.90  ? 167 LEU A C   1 
ATOM   1367 O O   . LEU A 1 186 ? 33.213 -29.414 -16.139 1.00 24.50  ? 167 LEU A O   1 
ATOM   1368 C CB  . LEU A 1 186 ? 30.337 -31.085 -16.979 1.00 28.84  ? 167 LEU A CB  1 
ATOM   1369 C CG  . LEU A 1 186 ? 29.051 -31.842 -16.676 1.00 34.76  ? 167 LEU A CG  1 
ATOM   1370 C CD1 . LEU A 1 186 ? 27.918 -30.922 -16.220 1.00 40.75  ? 167 LEU A CD1 1 
ATOM   1371 C CD2 . LEU A 1 186 ? 28.624 -32.651 -17.885 1.00 36.20  ? 167 LEU A CD2 1 
ATOM   1372 N N   . ASP A 1 187 ? 33.004 -31.682 -15.652 1.00 28.09  ? 168 ASP A N   1 
ATOM   1373 C CA  . ASP A 1 187 ? 34.386 -32.128 -15.958 1.00 29.84  ? 168 ASP A CA  1 
ATOM   1374 C C   . ASP A 1 187 ? 35.432 -31.190 -15.359 1.00 26.15  ? 168 ASP A C   1 
ATOM   1375 O O   . ASP A 1 187 ? 36.203 -30.573 -16.142 1.00 28.14  ? 168 ASP A O   1 
ATOM   1376 C CB  . ASP A 1 187 ? 34.594 -32.198 -17.471 1.00 35.47  ? 168 ASP A CB  1 
ATOM   1377 C CG  . ASP A 1 187 ? 33.924 -33.382 -18.126 1.00 44.51  ? 168 ASP A CG  1 
ATOM   1378 O OD1 . ASP A 1 187 ? 33.509 -34.312 -17.402 1.00 56.08  ? 168 ASP A OD1 1 
ATOM   1379 O OD2 . ASP A 1 187 ? 33.812 -33.353 -19.357 1.00 53.72  ? 168 ASP A OD2 1 
ATOM   1380 N N   . PHE A 1 188 ? 35.526 -31.104 -14.041 1.00 27.60  ? 169 PHE A N   1 
ATOM   1381 C CA  . PHE A 1 188 ? 36.575 -30.307 -13.355 1.00 30.23  ? 169 PHE A CA  1 
ATOM   1382 C C   . PHE A 1 188 ? 37.971 -30.883 -13.648 1.00 33.51  ? 169 PHE A C   1 
ATOM   1383 O O   . PHE A 1 188 ? 38.096 -32.125 -13.803 1.00 33.66  ? 169 PHE A O   1 
ATOM   1384 C CB  . PHE A 1 188 ? 36.331 -30.319 -11.849 1.00 32.29  ? 169 PHE A CB  1 
ATOM   1385 C CG  . PHE A 1 188 ? 35.216 -29.403 -11.446 1.00 30.55  ? 169 PHE A CG  1 
ATOM   1386 C CD1 . PHE A 1 188 ? 33.958 -29.539 -12.024 1.00 32.70  ? 169 PHE A CD1 1 
ATOM   1387 C CD2 . PHE A 1 188 ? 35.423 -28.396 -10.522 1.00 29.90  ? 169 PHE A CD2 1 
ATOM   1388 C CE1 . PHE A 1 188 ? 32.927 -28.680 -11.687 1.00 30.21  ? 169 PHE A CE1 1 
ATOM   1389 C CE2 . PHE A 1 188 ? 34.380 -27.556 -10.169 1.00 31.14  ? 169 PHE A CE2 1 
ATOM   1390 C CZ  . PHE A 1 188 ? 33.141 -27.695 -10.756 1.00 30.39  ? 169 PHE A CZ  1 
ATOM   1391 N N   . GLY A 1 189 ? 38.987 -30.014 -13.719 1.00 39.13  ? 170 GLY A N   1 
ATOM   1392 C CA  . GLY A 1 189 ? 40.412 -30.406 -13.775 1.00 44.70  ? 170 GLY A CA  1 
ATOM   1393 C C   . GLY A 1 189 ? 40.813 -31.188 -12.533 1.00 48.41  ? 170 GLY A C   1 
ATOM   1394 O O   . GLY A 1 189 ? 40.619 -30.660 -11.436 1.00 54.70  ? 170 GLY A O   1 
ATOM   1395 N N   . LEU A 1 190 ? 41.328 -32.408 -12.678 1.00 52.43  ? 171 LEU A N   1 
ATOM   1396 C CA  . LEU A 1 190 ? 41.678 -33.285 -11.517 1.00 58.79  ? 171 LEU A CA  1 
ATOM   1397 C C   . LEU A 1 190 ? 43.189 -33.565 -11.448 1.00 63.15  ? 171 LEU A C   1 
ATOM   1398 O O   . LEU A 1 190 ? 43.605 -34.361 -10.568 1.00 64.30  ? 171 LEU A O   1 
ATOM   1399 C CB  . LEU A 1 190 ? 40.896 -34.598 -11.628 1.00 59.19  ? 171 LEU A CB  1 
ATOM   1400 C CG  . LEU A 1 190 ? 39.375 -34.459 -11.634 1.00 65.34  ? 171 LEU A CG  1 
ATOM   1401 C CD1 . LEU A 1 190 ? 38.715 -35.777 -12.034 1.00 69.68  ? 171 LEU A CD1 1 
ATOM   1402 C CD2 . LEU A 1 190 ? 38.871 -33.974 -10.282 1.00 63.62  ? 171 LEU A CD2 1 
ATOM   1403 N N   . ALA A 1 191 ? 43.985 -32.969 -12.336 1.00 66.93  ? 172 ALA A N   1 
ATOM   1404 C CA  . ALA A 1 191 ? 45.452 -33.163 -12.394 1.00 77.49  ? 172 ALA A CA  1 
ATOM   1405 C C   . ALA A 1 191 ? 46.119 -32.151 -11.451 1.00 77.87  ? 172 ALA A C   1 
ATOM   1406 O O   . ALA A 1 191 ? 45.628 -30.991 -11.408 1.00 77.80  ? 172 ALA A O   1 
ATOM   1407 C CB  . ALA A 1 191 ? 45.935 -33.032 -13.825 1.00 78.02  ? 172 ALA A CB  1 
ATOM   1408 N N   . ARG A 1 192 ? 47.155 -32.582 -10.706 1.00 79.76  ? 173 ARG A N   1 
ATOM   1409 C CA  . ARG A 1 192 ? 48.030 -31.698 -9.874  1.00 82.90  ? 173 ARG A CA  1 
ATOM   1410 C C   . ARG A 1 192 ? 49.503 -31.852 -10.291 1.00 81.68  ? 173 ARG A C   1 
ATOM   1411 O O   . ARG A 1 192 ? 49.879 -32.968 -10.693 1.00 84.38  ? 173 ARG A O   1 
ATOM   1412 C CB  . ARG A 1 192 ? 47.817 -31.978 -8.378  1.00 81.21  ? 173 ARG A CB  1 
ATOM   1413 C CG  . ARG A 1 192 ? 46.872 -31.004 -7.677  1.00 75.42  ? 173 ARG A CG  1 
ATOM   1414 C CD  . ARG A 1 192 ? 45.550 -30.871 -8.409  1.00 74.91  ? 173 ARG A CD  1 
ATOM   1415 N NE  . ARG A 1 192 ? 44.439 -30.333 -7.633  1.00 72.25  ? 173 ARG A NE  1 
ATOM   1416 C CZ  . ARG A 1 192 ? 43.182 -30.217 -8.085  1.00 72.29  ? 173 ARG A CZ  1 
ATOM   1417 N NH1 . ARG A 1 192 ? 42.862 -30.583 -9.324  1.00 70.04  ? 173 ARG A NH1 1 
ATOM   1418 N NH2 . ARG A 1 192 ? 42.241 -29.737 -7.287  1.00 62.83  ? 173 ARG A NH2 1 
ATOM   1419 N N   . THR A 1 204 ? 42.754 -28.205 -26.224 1.00 68.68  ? 185 THR A N   1 
ATOM   1420 C CA  . THR A 1 204 ? 42.557 -26.832 -26.785 1.00 73.04  ? 185 THR A CA  1 
ATOM   1421 C C   . THR A 1 204 ? 42.790 -25.786 -25.690 1.00 70.37  ? 185 THR A C   1 
ATOM   1422 O O   . THR A 1 204 ? 42.126 -25.864 -24.627 1.00 64.22  ? 185 THR A O   1 
ATOM   1423 C CB  . THR A 1 204 ? 41.194 -26.656 -27.470 1.00 66.89  ? 185 THR A CB  1 
ATOM   1424 O OG1 . THR A 1 204 ? 41.408 -27.197 -28.773 1.00 71.39  ? 185 THR A OG1 1 
ATOM   1425 C CG2 . THR A 1 204 ? 40.714 -25.226 -27.583 1.00 62.52  ? 185 THR A CG2 1 
ATOM   1426 N N   . ARG A 1 205 ? 43.674 -24.833 -25.999 1.00 59.74  ? 186 ARG A N   1 
ATOM   1427 C CA  . ARG A 1 205 ? 44.205 -23.795 -25.081 1.00 57.00  ? 186 ARG A CA  1 
ATOM   1428 C C   . ARG A 1 205 ? 43.429 -22.482 -25.255 1.00 43.50  ? 186 ARG A C   1 
ATOM   1429 O O   . ARG A 1 205 ? 43.749 -21.506 -24.537 1.00 41.11  ? 186 ARG A O   1 
ATOM   1430 C CB  . ARG A 1 205 ? 45.669 -23.516 -25.440 1.00 63.18  ? 186 ARG A CB  1 
ATOM   1431 C CG  . ARG A 1 205 ? 46.630 -24.662 -25.172 1.00 68.82  ? 186 ARG A CG  1 
ATOM   1432 C CD  . ARG A 1 205 ? 48.034 -24.327 -25.663 1.00 74.89  ? 186 ARG A CD  1 
ATOM   1433 N NE  . ARG A 1 205 ? 48.085 -24.320 -27.121 1.00 71.84  ? 186 ARG A NE  1 
ATOM   1434 C CZ  . ARG A 1 205 ? 48.190 -25.407 -27.885 1.00 70.22  ? 186 ARG A CZ  1 
ATOM   1435 N NH1 . ARG A 1 205 ? 48.270 -26.615 -27.345 1.00 74.65  ? 186 ARG A NH1 1 
ATOM   1436 N NH2 . ARG A 1 205 ? 48.209 -25.277 -29.196 1.00 62.00  ? 186 ARG A NH2 1 
ATOM   1437 N N   . TRP A 1 206 ? 42.494 -22.437 -26.205 1.00 32.46  ? 187 TRP A N   1 
ATOM   1438 C CA  . TRP A 1 206 ? 41.823 -21.185 -26.651 1.00 32.96  ? 187 TRP A CA  1 
ATOM   1439 C C   . TRP A 1 206 ? 41.171 -20.412 -25.468 1.00 32.04  ? 187 TRP A C   1 
ATOM   1440 O O   . TRP A 1 206 ? 40.932 -19.197 -25.624 1.00 29.74  ? 187 TRP A O   1 
ATOM   1441 C CB  . TRP A 1 206 ? 40.815 -21.501 -27.774 1.00 32.24  ? 187 TRP A CB  1 
ATOM   1442 C CG  . TRP A 1 206 ? 41.391 -22.077 -29.042 1.00 33.94  ? 187 TRP A CG  1 
ATOM   1443 C CD1 . TRP A 1 206 ? 42.707 -22.148 -29.406 1.00 31.62  ? 187 TRP A CD1 1 
ATOM   1444 C CD2 . TRP A 1 206 ? 40.652 -22.630 -30.155 1.00 31.58  ? 187 TRP A CD2 1 
ATOM   1445 N NE1 . TRP A 1 206 ? 42.826 -22.709 -30.652 1.00 32.95  ? 187 TRP A NE1 1 
ATOM   1446 C CE2 . TRP A 1 206 ? 41.585 -23.004 -31.137 1.00 32.01  ? 187 TRP A CE2 1 
ATOM   1447 C CE3 . TRP A 1 206 ? 39.297 -22.837 -30.418 1.00 33.54  ? 187 TRP A CE3 1 
ATOM   1448 C CZ2 . TRP A 1 206 ? 41.209 -23.590 -32.342 1.00 33.09  ? 187 TRP A CZ2 1 
ATOM   1449 C CZ3 . TRP A 1 206 ? 38.920 -23.409 -31.610 1.00 33.03  ? 187 TRP A CZ3 1 
ATOM   1450 C CH2 . TRP A 1 206 ? 39.868 -23.793 -32.550 1.00 31.69  ? 187 TRP A CH2 1 
ATOM   1451 N N   . TYR A 1 207 ? 40.876 -21.072 -24.340 1.00 27.67  ? 188 TYR A N   1 
ATOM   1452 C CA  . TYR A 1 207 ? 40.058 -20.530 -23.222 1.00 28.98  ? 188 TYR A CA  1 
ATOM   1453 C C   . TYR A 1 207 ? 40.943 -20.412 -21.986 1.00 28.69  ? 188 TYR A C   1 
ATOM   1454 O O   . TYR A 1 207 ? 40.421 -19.986 -20.945 1.00 28.24  ? 188 TYR A O   1 
ATOM   1455 C CB  . TYR A 1 207 ? 38.799 -21.387 -22.986 1.00 26.80  ? 188 TYR A CB  1 
ATOM   1456 C CG  . TYR A 1 207 ? 37.981 -21.613 -24.232 1.00 25.39  ? 188 TYR A CG  1 
ATOM   1457 C CD1 . TYR A 1 207 ? 37.016 -20.705 -24.635 1.00 25.75  ? 188 TYR A CD1 1 
ATOM   1458 C CD2 . TYR A 1 207 ? 38.195 -22.723 -25.044 1.00 26.05  ? 188 TYR A CD2 1 
ATOM   1459 C CE1 . TYR A 1 207 ? 36.290 -20.885 -25.811 1.00 23.50  ? 188 TYR A CE1 1 
ATOM   1460 C CE2 . TYR A 1 207 ? 37.488 -22.919 -26.226 1.00 23.69  ? 188 TYR A CE2 1 
ATOM   1461 C CZ  . TYR A 1 207 ? 36.538 -21.989 -26.615 1.00 24.83  ? 188 TYR A CZ  1 
ATOM   1462 O OH  . TYR A 1 207 ? 35.845 -22.184 -27.783 1.00 23.37  ? 188 TYR A OH  1 
ATOM   1463 N N   . ARG A 1 208 ? 42.242 -20.717 -22.106 1.00 29.66  ? 189 ARG A N   1 
ATOM   1464 C CA  . ARG A 1 208 ? 43.173 -20.753 -20.950 1.00 29.09  ? 189 ARG A CA  1 
ATOM   1465 C C   . ARG A 1 208 ? 43.773 -19.369 -20.734 1.00 28.81  ? 189 ARG A C   1 
ATOM   1466 O O   . ARG A 1 208 ? 44.094 -18.676 -21.691 1.00 30.84  ? 189 ARG A O   1 
ATOM   1467 C CB  . ARG A 1 208 ? 44.249 -21.819 -21.129 1.00 34.94  ? 189 ARG A CB  1 
ATOM   1468 C CG  . ARG A 1 208 ? 45.025 -22.086 -19.847 1.00 42.67  ? 189 ARG A CG  1 
ATOM   1469 C CD  . ARG A 1 208 ? 45.894 -23.323 -19.879 1.00 51.50  ? 189 ARG A CD  1 
ATOM   1470 N NE  . ARG A 1 208 ? 45.050 -24.467 -20.162 1.00 60.24  ? 189 ARG A NE  1 
ATOM   1471 C CZ  . ARG A 1 208 ? 44.521 -25.264 -19.250 1.00 66.07  ? 189 ARG A CZ  1 
ATOM   1472 N NH1 . ARG A 1 208 ? 44.776 -25.085 -17.967 1.00 63.49  ? 189 ARG A NH1 1 
ATOM   1473 N NH2 . ARG A 1 208 ? 43.740 -26.253 -19.634 1.00 72.15  ? 189 ARG A NH2 1 
ATOM   1474 N N   . ALA A 1 209 ? 43.837 -18.962 -19.482 1.00 29.26  ? 190 ALA A N   1 
ATOM   1475 C CA  . ALA A 1 209 ? 44.497 -17.727 -19.021 1.00 31.58  ? 190 ALA A CA  1 
ATOM   1476 C C   . ALA A 1 209 ? 45.968 -17.778 -19.443 1.00 31.66  ? 190 ALA A C   1 
ATOM   1477 O O   . ALA A 1 209 ? 46.598 -18.839 -19.419 1.00 30.65  ? 190 ALA A O   1 
ATOM   1478 C CB  . ALA A 1 209 ? 44.345 -17.642 -17.517 1.00 31.47  ? 190 ALA A CB  1 
ATOM   1479 N N   . PRO A 1 210 ? 46.571 -16.646 -19.842 1.00 32.56  ? 191 PRO A N   1 
ATOM   1480 C CA  . PRO A 1 210 ? 47.953 -16.664 -20.316 1.00 36.72  ? 191 PRO A CA  1 
ATOM   1481 C C   . PRO A 1 210 ? 48.931 -17.099 -19.213 1.00 39.26  ? 191 PRO A C   1 
ATOM   1482 O O   . PRO A 1 210 ? 49.862 -17.838 -19.511 1.00 41.30  ? 191 PRO A O   1 
ATOM   1483 C CB  . PRO A 1 210 ? 48.211 -15.219 -20.730 1.00 36.71  ? 191 PRO A CB  1 
ATOM   1484 C CG  . PRO A 1 210 ? 46.842 -14.594 -20.829 1.00 37.43  ? 191 PRO A CG  1 
ATOM   1485 C CD  . PRO A 1 210 ? 45.987 -15.305 -19.811 1.00 35.34  ? 191 PRO A CD  1 
ATOM   1486 N N   . GLU A 1 211 ? 48.659 -16.693 -17.967 1.00 37.15  ? 192 GLU A N   1 
ATOM   1487 C CA  . GLU A 1 211 ? 49.578 -16.915 -16.831 1.00 40.92  ? 192 GLU A CA  1 
ATOM   1488 C C   . GLU A 1 211 ? 49.695 -18.413 -16.546 1.00 44.84  ? 192 GLU A C   1 
ATOM   1489 O O   . GLU A 1 211 ? 50.676 -18.799 -15.873 1.00 44.07  ? 192 GLU A O   1 
ATOM   1490 C CB  . GLU A 1 211 ? 49.128 -16.162 -15.579 1.00 40.25  ? 192 GLU A CB  1 
ATOM   1491 C CG  . GLU A 1 211 ? 47.825 -16.644 -14.964 1.00 39.82  ? 192 GLU A CG  1 
ATOM   1492 C CD  . GLU A 1 211 ? 46.586 -15.870 -15.375 1.00 36.06  ? 192 GLU A CD  1 
ATOM   1493 O OE1 . GLU A 1 211 ? 46.601 -15.285 -16.472 1.00 33.93  ? 192 GLU A OE1 1 
ATOM   1494 O OE2 . GLU A 1 211 ? 45.604 -15.867 -14.591 1.00 33.92  ? 192 GLU A OE2 1 
ATOM   1495 N N   . ILE A 1 212 ? 48.709 -19.220 -16.944 1.00 43.13  ? 193 ILE A N   1 
ATOM   1496 C CA  . ILE A 1 212 ? 48.811 -20.686 -16.689 1.00 45.98  ? 193 ILE A CA  1 
ATOM   1497 C C   . ILE A 1 212 ? 49.241 -21.388 -17.981 1.00 42.84  ? 193 ILE A C   1 
ATOM   1498 O O   . ILE A 1 212 ? 49.975 -22.381 -17.883 1.00 43.07  ? 193 ILE A O   1 
ATOM   1499 C CB  . ILE A 1 212 ? 47.540 -21.260 -16.042 1.00 52.80  ? 193 ILE A CB  1 
ATOM   1500 C CG1 . ILE A 1 212 ? 46.300 -21.057 -16.914 1.00 57.66  ? 193 ILE A CG1 1 
ATOM   1501 C CG2 . ILE A 1 212 ? 47.380 -20.658 -14.653 1.00 53.39  ? 193 ILE A CG2 1 
ATOM   1502 C CD1 . ILE A 1 212 ? 45.057 -21.757 -16.401 1.00 58.12  ? 193 ILE A CD1 1 
ATOM   1503 N N   . MET A 1 213 ? 48.893 -20.846 -19.142 1.00 39.79  ? 194 MET A N   1 
ATOM   1504 C CA  . MET A 1 213 ? 49.267 -21.470 -20.425 1.00 44.38  ? 194 MET A CA  1 
ATOM   1505 C C   . MET A 1 213 ? 50.804 -21.561 -20.522 1.00 45.14  ? 194 MET A C   1 
ATOM   1506 O O   . MET A 1 213 ? 51.297 -22.560 -21.040 1.00 39.02  ? 194 MET A O   1 
ATOM   1507 C CB  . MET A 1 213 ? 48.712 -20.666 -21.593 1.00 46.16  ? 194 MET A CB  1 
ATOM   1508 C CG  . MET A 1 213 ? 49.157 -21.226 -22.902 1.00 49.85  ? 194 MET A CG  1 
ATOM   1509 S SD  . MET A 1 213 ? 48.464 -20.336 -24.264 1.00 54.18  ? 194 MET A SD  1 
ATOM   1510 C CE  . MET A 1 213 ? 49.324 -18.772 -24.094 1.00 57.00  ? 194 MET A CE  1 
ATOM   1511 N N   . LEU A 1 214 ? 51.521 -20.554 -20.026 1.00 44.43  ? 195 LEU A N   1 
ATOM   1512 C CA  . LEU A 1 214 ? 53.001 -20.488 -20.039 1.00 48.61  ? 195 LEU A CA  1 
ATOM   1513 C C   . LEU A 1 214 ? 53.550 -20.627 -18.620 1.00 48.20  ? 195 LEU A C   1 
ATOM   1514 O O   . LEU A 1 214 ? 54.749 -20.366 -18.421 1.00 50.59  ? 195 LEU A O   1 
ATOM   1515 C CB  . LEU A 1 214 ? 53.413 -19.146 -20.651 1.00 51.11  ? 195 LEU A CB  1 
ATOM   1516 C CG  . LEU A 1 214 ? 53.014 -18.969 -22.113 1.00 53.71  ? 195 LEU A CG  1 
ATOM   1517 C CD1 . LEU A 1 214 ? 52.898 -17.494 -22.461 1.00 52.87  ? 195 LEU A CD1 1 
ATOM   1518 C CD2 . LEU A 1 214 ? 54.002 -19.688 -23.023 1.00 54.66  ? 195 LEU A CD2 1 
ATOM   1519 N N   . ASN A 1 215 ? 52.713 -20.961 -17.645 1.00 51.49  ? 196 ASN A N   1 
ATOM   1520 C CA  . ASN A 1 215 ? 53.227 -21.324 -16.308 1.00 51.25  ? 196 ASN A CA  1 
ATOM   1521 C C   . ASN A 1 215 ? 53.916 -20.094 -15.702 1.00 43.82  ? 196 ASN A C   1 
ATOM   1522 O O   . ASN A 1 215 ? 54.916 -20.252 -15.032 1.00 44.90  ? 196 ASN A O   1 
ATOM   1523 C CB  . ASN A 1 215 ? 54.159 -22.536 -16.456 1.00 58.35  ? 196 ASN A CB  1 
ATOM   1524 C CG  . ASN A 1 215 ? 54.530 -23.196 -15.145 1.00 70.50  ? 196 ASN A CG  1 
ATOM   1525 O OD1 . ASN A 1 215 ? 53.859 -23.008 -14.132 1.00 74.38  ? 196 ASN A OD1 1 
ATOM   1526 N ND2 . ASN A 1 215 ? 55.601 -23.977 -15.154 1.00 78.24  ? 196 ASN A ND2 1 
ATOM   1527 N N   . TRP A 1 216 ? 53.386 -18.894 -15.913 1.00 40.29  ? 197 TRP A N   1 
ATOM   1528 C CA  . TRP A 1 216 ? 53.983 -17.641 -15.390 1.00 38.40  ? 197 TRP A CA  1 
ATOM   1529 C C   . TRP A 1 216 ? 53.886 -17.589 -13.864 1.00 46.19  ? 197 TRP A C   1 
ATOM   1530 O O   . TRP A 1 216 ? 54.777 -16.967 -13.235 1.00 41.86  ? 197 TRP A O   1 
ATOM   1531 C CB  . TRP A 1 216 ? 53.320 -16.420 -16.023 1.00 39.93  ? 197 TRP A CB  1 
ATOM   1532 C CG  . TRP A 1 216 ? 53.690 -16.165 -17.452 1.00 37.97  ? 197 TRP A CG  1 
ATOM   1533 C CD1 . TRP A 1 216 ? 54.652 -16.770 -18.207 1.00 42.17  ? 197 TRP A CD1 1 
ATOM   1534 C CD2 . TRP A 1 216 ? 53.062 -15.211 -18.312 1.00 40.11  ? 197 TRP A CD2 1 
ATOM   1535 N NE1 . TRP A 1 216 ? 54.673 -16.251 -19.475 1.00 42.49  ? 197 TRP A NE1 1 
ATOM   1536 C CE2 . TRP A 1 216 ? 53.713 -15.283 -19.561 1.00 43.38  ? 197 TRP A CE2 1 
ATOM   1537 C CE3 . TRP A 1 216 ? 52.030 -14.289 -18.127 1.00 43.72  ? 197 TRP A CE3 1 
ATOM   1538 C CZ2 . TRP A 1 216 ? 53.357 -14.461 -20.626 1.00 47.84  ? 197 TRP A CZ2 1 
ATOM   1539 C CZ3 . TRP A 1 216 ? 51.680 -13.478 -19.177 1.00 43.64  ? 197 TRP A CZ3 1 
ATOM   1540 C CH2 . TRP A 1 216 ? 52.333 -13.569 -20.408 1.00 47.05  ? 197 TRP A CH2 1 
ATOM   1541 N N   . MET A 1 217 ? 52.826 -18.158 -13.279 1.00 53.66  ? 198 MET A N   1 
ATOM   1542 C CA  . MET A 1 217 ? 52.597 -18.080 -11.813 1.00 57.17  ? 198 MET A CA  1 
ATOM   1543 C C   . MET A 1 217 ? 51.539 -19.109 -11.394 1.00 64.55  ? 198 MET A C   1 
ATOM   1544 O O   . MET A 1 217 ? 50.982 -19.787 -12.283 1.00 62.37  ? 198 MET A O   1 
ATOM   1545 C CB  . MET A 1 217 ? 52.161 -16.660 -11.431 1.00 58.81  ? 198 MET A CB  1 
ATOM   1546 C CG  . MET A 1 217 ? 50.889 -16.218 -12.123 1.00 59.28  ? 198 MET A CG  1 
ATOM   1547 S SD  . MET A 1 217 ? 50.546 -14.458 -11.877 1.00 57.33  ? 198 MET A SD  1 
ATOM   1548 C CE  . MET A 1 217 ? 51.666 -13.739 -13.071 1.00 56.18  ? 198 MET A CE  1 
ATOM   1549 N N   . HIS A 1 218 ? 51.283 -19.229 -10.089 1.00 74.80  ? 199 HIS A N   1 
ATOM   1550 C CA  . HIS A 1 218 ? 50.275 -20.163 -9.520  1.00 87.88  ? 199 HIS A CA  1 
ATOM   1551 C C   . HIS A 1 218 ? 48.871 -19.816 -10.051 1.00 77.85  ? 199 HIS A C   1 
ATOM   1552 O O   . HIS A 1 218 ? 48.548 -18.615 -10.130 1.00 78.70  ? 199 HIS A O   1 
ATOM   1553 C CB  . HIS A 1 218 ? 50.358 -20.162 -7.982  1.00 104.02 ? 199 HIS A CB  1 
ATOM   1554 C CG  . HIS A 1 218 ? 49.914 -18.885 -7.344  1.00 125.14 ? 199 HIS A CG  1 
ATOM   1555 N ND1 . HIS A 1 218 ? 50.758 -17.798 -7.197  1.00 138.38 ? 199 HIS A ND1 1 
ATOM   1556 C CD2 . HIS A 1 218 ? 48.721 -18.511 -6.823  1.00 132.94 ? 199 HIS A CD2 1 
ATOM   1557 C CE1 . HIS A 1 218 ? 50.105 -16.812 -6.608  1.00 140.46 ? 199 HIS A CE1 1 
ATOM   1558 N NE2 . HIS A 1 218 ? 48.852 -17.226 -6.367  1.00 136.83 ? 199 HIS A NE2 1 
ATOM   1559 N N   . TYR A 1 219 ? 48.093 -20.835 -10.440 1.00 79.29  ? 200 TYR A N   1 
ATOM   1560 C CA  . TYR A 1 219 ? 46.608 -20.808 -10.531 1.00 79.94  ? 200 TYR A CA  1 
ATOM   1561 C C   . TYR A 1 219 ? 46.020 -19.942 -9.406  1.00 69.61  ? 200 TYR A C   1 
ATOM   1562 O O   . TYR A 1 219 ? 46.221 -20.285 -8.235  1.00 69.16  ? 200 TYR A O   1 
ATOM   1563 C CB  . TYR A 1 219 ? 46.012 -22.202 -10.294 1.00 86.01  ? 200 TYR A CB  1 
ATOM   1564 C CG  . TYR A 1 219 ? 46.185 -23.247 -11.369 1.00 93.46  ? 200 TYR A CG  1 
ATOM   1565 C CD1 . TYR A 1 219 ? 46.016 -22.937 -12.707 1.00 99.62  ? 200 TYR A CD1 1 
ATOM   1566 C CD2 . TYR A 1 219 ? 46.414 -24.580 -11.041 1.00 100.14 ? 200 TYR A CD2 1 
ATOM   1567 C CE1 . TYR A 1 219 ? 46.124 -23.901 -13.699 1.00 101.79 ? 200 TYR A CE1 1 
ATOM   1568 C CE2 . TYR A 1 219 ? 46.530 -25.557 -12.020 1.00 104.71 ? 200 TYR A CE2 1 
ATOM   1569 C CZ  . TYR A 1 219 ? 46.388 -25.216 -13.355 1.00 105.44 ? 200 TYR A CZ  1 
ATOM   1570 O OH  . TYR A 1 219 ? 46.493 -26.173 -14.324 1.00 98.91  ? 200 TYR A OH  1 
ATOM   1571 N N   . ASN A 1 220 ? 45.321 -18.857 -9.731  1.00 62.52  ? 201 ASN A N   1 
ATOM   1572 C CA  . ASN A 1 220 ? 44.259 -18.320 -8.842  1.00 64.56  ? 201 ASN A CA  1 
ATOM   1573 C C   . ASN A 1 220 ? 42.908 -18.552 -9.529  1.00 53.32  ? 201 ASN A C   1 
ATOM   1574 O O   . ASN A 1 220 ? 42.857 -18.854 -10.738 1.00 42.14  ? 201 ASN A O   1 
ATOM   1575 C CB  . ASN A 1 220 ? 44.478 -16.866 -8.403  1.00 66.61  ? 201 ASN A CB  1 
ATOM   1576 C CG  . ASN A 1 220 ? 44.177 -15.846 -9.479  1.00 76.66  ? 201 ASN A CG  1 
ATOM   1577 O OD1 . ASN A 1 220 ? 44.001 -16.191 -10.648 1.00 76.83  ? 201 ASN A OD1 1 
ATOM   1578 N ND2 . ASN A 1 220 ? 44.150 -14.579 -9.098  1.00 78.58  ? 201 ASN A ND2 1 
ATOM   1579 N N   . GLN A 1 221 ? 41.840 -18.412 -8.757  1.00 46.33  ? 202 GLN A N   1 
ATOM   1580 C CA  . GLN A 1 221 ? 40.479 -18.786 -9.202  1.00 42.04  ? 202 GLN A CA  1 
ATOM   1581 C C   . GLN A 1 221 ? 40.067 -17.880 -10.376 1.00 36.75  ? 202 GLN A C   1 
ATOM   1582 O O   . GLN A 1 221 ? 39.244 -18.343 -11.163 1.00 29.42  ? 202 GLN A O   1 
ATOM   1583 C CB  . GLN A 1 221 ? 39.545 -18.777 -8.000  1.00 36.44  ? 202 GLN A CB  1 
ATOM   1584 C CG  . GLN A 1 221 ? 39.373 -17.405 -7.409  1.00 37.21  ? 202 GLN A CG  1 
ATOM   1585 C CD  . GLN A 1 221 ? 38.656 -17.491 -6.085  1.00 41.97  ? 202 GLN A CD  1 
ATOM   1586 O OE1 . GLN A 1 221 ? 38.752 -18.476 -5.355  1.00 36.66  ? 202 GLN A OE1 1 
ATOM   1587 N NE2 . GLN A 1 221 ? 37.894 -16.456 -5.790  1.00 42.44  ? 202 GLN A NE2 1 
ATOM   1588 N N   . THR A 1 222 ? 40.696 -16.708 -10.553 1.00 33.28  ? 203 THR A N   1 
ATOM   1589 C CA  . THR A 1 222 ? 40.361 -15.771 -11.652 1.00 37.21  ? 203 THR A CA  1 
ATOM   1590 C C   . THR A 1 222 ? 40.854 -16.297 -12.993 1.00 33.11  ? 203 THR A C   1 
ATOM   1591 O O   . THR A 1 222 ? 40.473 -15.661 -13.978 1.00 29.14  ? 203 THR A O   1 
ATOM   1592 C CB  . THR A 1 222 ? 40.920 -14.358 -11.455 1.00 45.31  ? 203 THR A CB  1 
ATOM   1593 O OG1 . THR A 1 222 ? 42.326 -14.524 -11.312 1.00 49.28  ? 203 THR A OG1 1 
ATOM   1594 C CG2 . THR A 1 222 ? 40.318 -13.656 -10.254 1.00 51.18  ? 203 THR A CG2 1 
ATOM   1595 N N   . VAL A 1 223 ? 41.597 -17.416 -13.052 1.00 28.94  ? 204 VAL A N   1 
ATOM   1596 C CA  . VAL A 1 223 ? 41.842 -18.120 -14.351 1.00 27.61  ? 204 VAL A CA  1 
ATOM   1597 C C   . VAL A 1 223 ? 40.493 -18.529 -14.958 1.00 25.60  ? 204 VAL A C   1 
ATOM   1598 O O   . VAL A 1 223 ? 40.334 -18.481 -16.201 1.00 24.21  ? 204 VAL A O   1 
ATOM   1599 C CB  . VAL A 1 223 ? 42.756 -19.350 -14.218 1.00 29.22  ? 204 VAL A CB  1 
ATOM   1600 C CG1 . VAL A 1 223 ? 44.130 -18.993 -13.696 1.00 30.38  ? 204 VAL A CG1 1 
ATOM   1601 C CG2 . VAL A 1 223 ? 42.113 -20.441 -13.379 1.00 29.83  ? 204 VAL A CG2 1 
ATOM   1602 N N   . ASP A 1 224 ? 39.553 -18.956 -14.115 1.00 24.12  ? 205 ASP A N   1 
ATOM   1603 C CA  . ASP A 1 224 ? 38.197 -19.327 -14.568 1.00 22.41  ? 205 ASP A CA  1 
ATOM   1604 C C   . ASP A 1 224 ? 37.507 -18.103 -15.174 1.00 22.61  ? 205 ASP A C   1 
ATOM   1605 O O   . ASP A 1 224 ? 36.741 -18.268 -16.150 1.00 21.48  ? 205 ASP A O   1 
ATOM   1606 C CB  . ASP A 1 224 ? 37.409 -19.968 -13.435 1.00 22.35  ? 205 ASP A CB  1 
ATOM   1607 C CG  . ASP A 1 224 ? 37.938 -21.323 -13.018 1.00 23.06  ? 205 ASP A CG  1 
ATOM   1608 O OD1 . ASP A 1 224 ? 38.596 -21.983 -13.850 1.00 21.19  ? 205 ASP A OD1 1 
ATOM   1609 O OD2 . ASP A 1 224 ? 37.705 -21.693 -11.858 1.00 26.37  ? 205 ASP A OD2 1 
ATOM   1610 N N   . ILE A 1 225 ? 37.736 -16.909 -14.624 1.00 23.15  ? 206 ILE A N   1 
ATOM   1611 C CA  . ILE A 1 225 ? 37.026 -15.688 -15.115 1.00 23.70  ? 206 ILE A CA  1 
ATOM   1612 C C   . ILE A 1 225 ? 37.505 -15.380 -16.544 1.00 23.93  ? 206 ILE A C   1 
ATOM   1613 O O   . ILE A 1 225 ? 36.665 -14.993 -17.369 1.00 22.52  ? 206 ILE A O   1 
ATOM   1614 C CB  . ILE A 1 225 ? 37.194 -14.503 -14.151 1.00 25.12  ? 206 ILE A CB  1 
ATOM   1615 C CG1 . ILE A 1 225 ? 36.560 -14.779 -12.781 1.00 24.91  ? 206 ILE A CG1 1 
ATOM   1616 C CG2 . ILE A 1 225 ? 36.630 -13.239 -14.789 1.00 26.46  ? 206 ILE A CG2 1 
ATOM   1617 C CD1 . ILE A 1 225 ? 35.032 -14.971 -12.834 1.00 27.44  ? 206 ILE A CD1 1 
ATOM   1618 N N   . TRP A 1 226 ? 38.803 -15.567 -16.813 1.00 24.13  ? 207 TRP A N   1 
ATOM   1619 C CA  . TRP A 1 226 ? 39.419 -15.418 -18.151 1.00 23.22  ? 207 TRP A CA  1 
ATOM   1620 C C   . TRP A 1 226 ? 38.663 -16.307 -19.115 1.00 22.69  ? 207 TRP A C   1 
ATOM   1621 O O   . TRP A 1 226 ? 38.246 -15.829 -20.179 1.00 23.12  ? 207 TRP A O   1 
ATOM   1622 C CB  . TRP A 1 226 ? 40.912 -15.763 -18.144 1.00 24.49  ? 207 TRP A CB  1 
ATOM   1623 C CG  . TRP A 1 226 ? 41.517 -15.569 -19.500 1.00 25.72  ? 207 TRP A CG  1 
ATOM   1624 C CD1 . TRP A 1 226 ? 41.584 -16.495 -20.492 1.00 24.17  ? 207 TRP A CD1 1 
ATOM   1625 C CD2 . TRP A 1 226 ? 42.076 -14.356 -20.033 1.00 26.28  ? 207 TRP A CD2 1 
ATOM   1626 N NE1 . TRP A 1 226 ? 42.124 -15.940 -21.611 1.00 27.71  ? 207 TRP A NE1 1 
ATOM   1627 C CE2 . TRP A 1 226 ? 42.458 -14.634 -21.358 1.00 27.46  ? 207 TRP A CE2 1 
ATOM   1628 C CE3 . TRP A 1 226 ? 42.283 -13.061 -19.536 1.00 29.90  ? 207 TRP A CE3 1 
ATOM   1629 C CZ2 . TRP A 1 226 ? 43.069 -13.677 -22.172 1.00 27.72  ? 207 TRP A CZ2 1 
ATOM   1630 C CZ3 . TRP A 1 226 ? 42.853 -12.103 -20.354 1.00 28.51  ? 207 TRP A CZ3 1 
ATOM   1631 C CH2 . TRP A 1 226 ? 43.268 -12.415 -21.647 1.00 25.79  ? 207 TRP A CH2 1 
ATOM   1632 N N   . SER A 1 227 ? 38.508 -17.569 -18.740 1.00 23.77  ? 208 SER A N   1 
ATOM   1633 C CA  . SER A 1 227 ? 37.789 -18.576 -19.557 1.00 22.97  ? 208 SER A CA  1 
ATOM   1634 C C   . SER A 1 227 ? 36.359 -18.093 -19.854 1.00 20.68  ? 208 SER A C   1 
ATOM   1635 O O   . SER A 1 227 ? 35.953 -18.176 -21.030 1.00 22.74  ? 208 SER A O   1 
ATOM   1636 C CB  . SER A 1 227 ? 37.812 -19.929 -18.892 1.00 25.80  ? 208 SER A CB  1 
ATOM   1637 O OG  . SER A 1 227 ? 39.140 -20.373 -18.591 1.00 25.68  ? 208 SER A OG  1 
ATOM   1638 N N   . VAL A 1 228 ? 35.605 -17.621 -18.863 1.00 18.77  ? 209 VAL A N   1 
ATOM   1639 C CA  . VAL A 1 228 ? 34.217 -17.104 -19.085 1.00 18.94  ? 209 VAL A CA  1 
ATOM   1640 C C   . VAL A 1 228 ? 34.251 -15.946 -20.092 1.00 19.23  ? 209 VAL A C   1 
ATOM   1641 O O   . VAL A 1 228 ? 33.384 -15.898 -20.972 1.00 20.83  ? 209 VAL A O   1 
ATOM   1642 C CB  . VAL A 1 228 ? 33.562 -16.644 -17.774 1.00 19.81  ? 209 VAL A CB  1 
ATOM   1643 C CG1 . VAL A 1 228 ? 32.200 -16.029 -18.009 1.00 19.23  ? 209 VAL A CG1 1 
ATOM   1644 C CG2 . VAL A 1 228 ? 33.438 -17.759 -16.732 1.00 20.97  ? 209 VAL A CG2 1 
ATOM   1645 N N   . GLY A 1 229 ? 35.228 -15.050 -19.982 1.00 19.84  ? 210 GLY A N   1 
ATOM   1646 C CA  . GLY A 1 229 ? 35.399 -13.947 -20.946 1.00 22.55  ? 210 GLY A CA  1 
ATOM   1647 C C   . GLY A 1 229 ? 35.587 -14.466 -22.367 1.00 21.49  ? 210 GLY A C   1 
ATOM   1648 O O   . GLY A 1 229 ? 34.871 -14.037 -23.274 1.00 20.74  ? 210 GLY A O   1 
ATOM   1649 N N   . CYS A 1 230 ? 36.424 -15.468 -22.541 1.00 22.87  ? 211 CYS A N   1 
ATOM   1650 C CA  . CYS A 1 230 ? 36.682 -16.066 -23.880 1.00 25.02  ? 211 CYS A CA  1 
ATOM   1651 C C   . CYS A 1 230 ? 35.402 -16.670 -24.420 1.00 23.49  ? 211 CYS A C   1 
ATOM   1652 O O   . CYS A 1 230 ? 35.123 -16.482 -25.607 1.00 26.37  ? 211 CYS A O   1 
ATOM   1653 C CB  . CYS A 1 230 ? 37.758 -17.141 -23.824 1.00 26.42  ? 211 CYS A CB  1 
ATOM   1654 S SG  . CYS A 1 230 ? 39.372 -16.431 -23.447 1.00 27.10  ? 211 CYS A SG  1 
ATOM   1655 N N   . ILE A 1 231 ? 34.644 -17.356 -23.561 1.00 24.27  ? 212 ILE A N   1 
ATOM   1656 C CA  . ILE A 1 231 ? 33.370 -18.037 -23.958 1.00 21.61  ? 212 ILE A CA  1 
ATOM   1657 C C   . ILE A 1 231 ? 32.327 -16.990 -24.351 1.00 21.40  ? 212 ILE A C   1 
ATOM   1658 O O   . ILE A 1 231 ? 31.680 -17.142 -25.377 1.00 20.51  ? 212 ILE A O   1 
ATOM   1659 C CB  . ILE A 1 231 ? 32.861 -18.938 -22.813 1.00 21.70  ? 212 ILE A CB  1 
ATOM   1660 C CG1 . ILE A 1 231 ? 33.828 -20.100 -22.563 1.00 19.89  ? 212 ILE A CG1 1 
ATOM   1661 C CG2 . ILE A 1 231 ? 31.461 -19.419 -23.137 1.00 21.97  ? 212 ILE A CG2 1 
ATOM   1662 C CD1 . ILE A 1 231 ? 33.656 -20.825 -21.235 1.00 20.44  ? 212 ILE A CD1 1 
ATOM   1663 N N   . MET A 1 232 ? 32.149 -15.968 -23.526 1.00 21.61  ? 213 MET A N   1 
ATOM   1664 C CA  . MET A 1 232 ? 31.127 -14.921 -23.771 1.00 21.65  ? 213 MET A CA  1 
ATOM   1665 C C   . MET A 1 232 ? 31.440 -14.210 -25.084 1.00 20.49  ? 213 MET A C   1 
ATOM   1666 O O   . MET A 1 232 ? 30.511 -13.966 -25.843 1.00 19.79  ? 213 MET A O   1 
ATOM   1667 C CB  . MET A 1 232 ? 31.118 -13.912 -22.620 1.00 22.95  ? 213 MET A CB  1 
ATOM   1668 C CG  . MET A 1 232 ? 30.089 -12.814 -22.759 1.00 24.22  ? 213 MET A CG  1 
ATOM   1669 S SD  . MET A 1 232 ? 29.970 -11.862 -21.229 1.00 25.68  ? 213 MET A SD  1 
ATOM   1670 C CE  . MET A 1 232 ? 28.894 -10.583 -21.828 1.00 25.74  ? 213 MET A CE  1 
ATOM   1671 N N   . ALA A 1 233 ? 32.687 -13.825 -25.321 1.00 21.11  ? 214 ALA A N   1 
ATOM   1672 C CA  . ALA A 1 233 ? 33.047 -13.096 -26.558 1.00 23.60  ? 214 ALA A CA  1 
ATOM   1673 C C   . ALA A 1 233 ? 32.556 -13.888 -27.782 1.00 22.95  ? 214 ALA A C   1 
ATOM   1674 O O   . ALA A 1 233 ? 31.872 -13.329 -28.632 1.00 23.75  ? 214 ALA A O   1 
ATOM   1675 C CB  . ALA A 1 233 ? 34.541 -12.881 -26.595 1.00 22.83  ? 214 ALA A CB  1 
ATOM   1676 N N   . GLU A 1 234 ? 32.935 -15.160 -27.850 1.00 25.49  ? 215 GLU A N   1 
ATOM   1677 C CA  . GLU A 1 234 ? 32.588 -16.135 -28.910 1.00 24.92  ? 215 GLU A CA  1 
ATOM   1678 C C   . GLU A 1 234 ? 31.066 -16.271 -29.032 1.00 24.99  ? 215 GLU A C   1 
ATOM   1679 O O   . GLU A 1 234 ? 30.587 -16.321 -30.183 1.00 26.49  ? 215 GLU A O   1 
ATOM   1680 C CB  . GLU A 1 234 ? 33.293 -17.461 -28.583 1.00 28.59  ? 215 GLU A CB  1 
ATOM   1681 C CG  . GLU A 1 234 ? 32.928 -18.640 -29.458 1.00 31.96  ? 215 GLU A CG  1 
ATOM   1682 C CD  . GLU A 1 234 ? 33.761 -19.882 -29.147 1.00 34.73  ? 215 GLU A CD  1 
ATOM   1683 O OE1 . GLU A 1 234 ? 34.654 -19.799 -28.335 1.00 33.14  ? 215 GLU A OE1 1 
ATOM   1684 O OE2 . GLU A 1 234 ? 33.525 -20.923 -29.748 1.00 43.40  ? 215 GLU A OE2 1 
ATOM   1685 N N   . LEU A 1 235 ? 30.307 -16.336 -27.928 1.00 24.82  ? 216 LEU A N   1 
ATOM   1686 C CA  . LEU A 1 235 ? 28.816 -16.462 -28.004 1.00 24.26  ? 216 LEU A CA  1 
ATOM   1687 C C   . LEU A 1 235 ? 28.227 -15.171 -28.579 1.00 25.56  ? 216 LEU A C   1 
ATOM   1688 O O   . LEU A 1 235 ? 27.201 -15.254 -29.271 1.00 27.63  ? 216 LEU A O   1 
ATOM   1689 C CB  . LEU A 1 235 ? 28.204 -16.707 -26.627 1.00 24.43  ? 216 LEU A CB  1 
ATOM   1690 C CG  . LEU A 1 235 ? 28.511 -18.027 -25.926 1.00 22.43  ? 216 LEU A CG  1 
ATOM   1691 C CD1 . LEU A 1 235 ? 27.635 -18.164 -24.690 1.00 23.40  ? 216 LEU A CD1 1 
ATOM   1692 C CD2 . LEU A 1 235 ? 28.282 -19.212 -26.815 1.00 23.70  ? 216 LEU A CD2 1 
ATOM   1693 N N   . LEU A 1 236 ? 28.829 -14.015 -28.273 1.00 25.38  ? 217 LEU A N   1 
ATOM   1694 C CA  . LEU A 1 236 ? 28.368 -12.694 -28.809 1.00 27.13  ? 217 LEU A CA  1 
ATOM   1695 C C   . LEU A 1 236 ? 28.658 -12.596 -30.309 1.00 27.28  ? 217 LEU A C   1 
ATOM   1696 O O   . LEU A 1 236 ? 27.825 -12.030 -30.991 1.00 26.08  ? 217 LEU A O   1 
ATOM   1697 C CB  . LEU A 1 236 ? 29.024 -11.523 -28.074 1.00 25.34  ? 217 LEU A CB  1 
ATOM   1698 C CG  . LEU A 1 236 ? 28.563 -11.318 -26.635 1.00 27.44  ? 217 LEU A CG  1 
ATOM   1699 C CD1 . LEU A 1 236 ? 29.396 -10.262 -25.962 1.00 27.99  ? 217 LEU A CD1 1 
ATOM   1700 C CD2 . LEU A 1 236 ? 27.101 -10.945 -26.563 1.00 28.23  ? 217 LEU A CD2 1 
ATOM   1701 N N   . THR A 1 237 ? 29.829 -13.037 -30.765 1.00 28.32  ? 218 THR A N   1 
ATOM   1702 C CA  . THR A 1 237 ? 30.318 -12.700 -32.129 1.00 28.59  ? 218 THR A CA  1 
ATOM   1703 C C   . THR A 1 237 ? 30.143 -13.862 -33.100 1.00 31.05  ? 218 THR A C   1 
ATOM   1704 O O   . THR A 1 237 ? 29.987 -13.587 -34.285 1.00 33.86  ? 218 THR A O   1 
ATOM   1705 C CB  . THR A 1 237 ? 31.793 -12.315 -32.138 1.00 28.97  ? 218 THR A CB  1 
ATOM   1706 O OG1 . THR A 1 237 ? 32.570 -13.441 -31.719 1.00 29.38  ? 218 THR A OG1 1 
ATOM   1707 C CG2 . THR A 1 237 ? 32.057 -11.111 -31.255 1.00 28.78  ? 218 THR A CG2 1 
ATOM   1708 N N   . GLY A 1 238 ? 30.136 -15.091 -32.600 1.00 27.86  ? 219 GLY A N   1 
ATOM   1709 C CA  . GLY A 1 238 ? 30.083 -16.292 -33.437 1.00 29.56  ? 219 GLY A CA  1 
ATOM   1710 C C   . GLY A 1 238 ? 31.480 -16.729 -33.823 1.00 30.14  ? 219 GLY A C   1 
ATOM   1711 O O   . GLY A 1 238 ? 31.581 -17.634 -34.631 1.00 35.05  ? 219 GLY A O   1 
ATOM   1712 N N   . ARG A 1 239 ? 32.518 -16.141 -33.240 1.00 30.45  ? 220 ARG A N   1 
ATOM   1713 C CA  . ARG A 1 239 ? 33.933 -16.369 -33.640 1.00 32.67  ? 220 ARG A CA  1 
ATOM   1714 C C   . ARG A 1 239 ? 34.750 -16.695 -32.386 1.00 32.88  ? 220 ARG A C   1 
ATOM   1715 O O   . ARG A 1 239 ? 34.588 -15.991 -31.386 1.00 36.83  ? 220 ARG A O   1 
ATOM   1716 C CB  . ARG A 1 239 ? 34.446 -15.113 -34.363 1.00 35.09  ? 220 ARG A CB  1 
ATOM   1717 C CG  . ARG A 1 239 ? 33.545 -14.665 -35.515 1.00 37.50  ? 220 ARG A CG  1 
ATOM   1718 C CD  . ARG A 1 239 ? 34.169 -13.634 -36.454 1.00 42.04  ? 220 ARG A CD  1 
ATOM   1719 N NE  . ARG A 1 239 ? 34.450 -12.449 -35.686 1.00 39.66  ? 220 ARG A NE  1 
ATOM   1720 C CZ  . ARG A 1 239 ? 33.574 -11.467 -35.494 1.00 47.60  ? 220 ARG A CZ  1 
ATOM   1721 N NH1 . ARG A 1 239 ? 32.387 -11.521 -36.092 1.00 49.00  ? 220 ARG A NH1 1 
ATOM   1722 N NH2 . ARG A 1 239 ? 33.880 -10.454 -34.694 1.00 38.22  ? 220 ARG A NH2 1 
ATOM   1723 N N   . THR A 1 240 ? 35.577 -17.735 -32.400 1.00 29.23  ? 221 THR A N   1 
ATOM   1724 C CA  . THR A 1 240 ? 36.552 -17.960 -31.304 1.00 31.27  ? 221 THR A CA  1 
ATOM   1725 C C   . THR A 1 240 ? 37.420 -16.695 -31.144 1.00 33.94  ? 221 THR A C   1 
ATOM   1726 O O   . THR A 1 240 ? 37.817 -16.067 -32.150 1.00 30.94  ? 221 THR A O   1 
ATOM   1727 C CB  . THR A 1 240 ? 37.401 -19.196 -31.562 1.00 30.23  ? 221 THR A CB  1 
ATOM   1728 O OG1 . THR A 1 240 ? 36.516 -20.285 -31.750 1.00 37.40  ? 221 THR A OG1 1 
ATOM   1729 C CG2 . THR A 1 240 ? 38.382 -19.500 -30.465 1.00 31.27  ? 221 THR A CG2 1 
ATOM   1730 N N   . LEU A 1 241 ? 37.675 -16.287 -29.910 1.00 32.09  ? 222 LEU A N   1 
ATOM   1731 C CA  . LEU A 1 241 ? 38.298 -14.975 -29.669 1.00 31.77  ? 222 LEU A CA  1 
ATOM   1732 C C   . LEU A 1 241 ? 39.787 -15.111 -29.992 1.00 31.59  ? 222 LEU A C   1 
ATOM   1733 O O   . LEU A 1 241 ? 40.296 -14.245 -30.696 1.00 31.68  ? 222 LEU A O   1 
ATOM   1734 C CB  . LEU A 1 241 ? 38.063 -14.521 -28.223 1.00 29.78  ? 222 LEU A CB  1 
ATOM   1735 C CG  . LEU A 1 241 ? 38.691 -13.175 -27.869 1.00 29.05  ? 222 LEU A CG  1 
ATOM   1736 C CD1 . LEU A 1 241 ? 38.192 -12.094 -28.788 1.00 28.42  ? 222 LEU A CD1 1 
ATOM   1737 C CD2 . LEU A 1 241 ? 38.420 -12.821 -26.420 1.00 31.18  ? 222 LEU A CD2 1 
ATOM   1738 N N   . PHE A 1 242 ? 40.432 -16.150 -29.462 1.00 30.53  ? 223 PHE A N   1 
ATOM   1739 C CA  . PHE A 1 242 ? 41.901 -16.347 -29.510 1.00 30.98  ? 223 PHE A CA  1 
ATOM   1740 C C   . PHE A 1 242 ? 42.227 -17.733 -30.066 1.00 30.73  ? 223 PHE A C   1 
ATOM   1741 O O   . PHE A 1 242 ? 42.766 -18.556 -29.347 1.00 33.67  ? 223 PHE A O   1 
ATOM   1742 C CB  . PHE A 1 242 ? 42.495 -16.199 -28.107 1.00 30.41  ? 223 PHE A CB  1 
ATOM   1743 C CG  . PHE A 1 242 ? 42.251 -14.880 -27.414 1.00 36.56  ? 223 PHE A CG  1 
ATOM   1744 C CD1 . PHE A 1 242 ? 42.664 -13.673 -27.980 1.00 38.22  ? 223 PHE A CD1 1 
ATOM   1745 C CD2 . PHE A 1 242 ? 41.674 -14.848 -26.153 1.00 35.90  ? 223 PHE A CD2 1 
ATOM   1746 C CE1 . PHE A 1 242 ? 42.466 -12.471 -27.320 1.00 35.03  ? 223 PHE A CE1 1 
ATOM   1747 C CE2 . PHE A 1 242 ? 41.497 -13.643 -25.487 1.00 36.21  ? 223 PHE A CE2 1 
ATOM   1748 C CZ  . PHE A 1 242 ? 41.897 -12.461 -26.070 1.00 35.69  ? 223 PHE A CZ  1 
ATOM   1749 N N   . PRO A 1 243 ? 41.907 -18.060 -31.336 1.00 30.72  ? 224 PRO A N   1 
ATOM   1750 C CA  . PRO A 1 243 ? 42.107 -19.420 -31.864 1.00 34.95  ? 224 PRO A CA  1 
ATOM   1751 C C   . PRO A 1 243 ? 43.545 -19.668 -32.344 1.00 35.00  ? 224 PRO A C   1 
ATOM   1752 O O   . PRO A 1 243 ? 43.757 -19.918 -33.511 1.00 35.56  ? 224 PRO A O   1 
ATOM   1753 C CB  . PRO A 1 243 ? 41.127 -19.485 -33.039 1.00 32.21  ? 224 PRO A CB  1 
ATOM   1754 C CG  . PRO A 1 243 ? 41.081 -18.033 -33.548 1.00 31.65  ? 224 PRO A CG  1 
ATOM   1755 C CD  . PRO A 1 243 ? 41.279 -17.167 -32.314 1.00 30.29  ? 224 PRO A CD  1 
ATOM   1756 N N   . GLY A 1 244 ? 44.498 -19.545 -31.426 1.00 35.44  ? 225 GLY A N   1 
ATOM   1757 C CA  . GLY A 1 244 ? 45.934 -19.709 -31.699 1.00 40.42  ? 225 GLY A CA  1 
ATOM   1758 C C   . GLY A 1 244 ? 46.267 -21.170 -31.972 1.00 41.93  ? 225 GLY A C   1 
ATOM   1759 O O   . GLY A 1 244 ? 45.449 -22.024 -31.592 1.00 44.31  ? 225 GLY A O   1 
ATOM   1760 N N   . THR A 1 245 ? 47.402 -21.446 -32.622 1.00 37.32  ? 226 THR A N   1 
ATOM   1761 C CA  . THR A 1 245 ? 47.788 -22.821 -33.041 1.00 37.83  ? 226 THR A CA  1 
ATOM   1762 C C   . THR A 1 245 ? 48.855 -23.375 -32.118 1.00 37.49  ? 226 THR A C   1 
ATOM   1763 O O   . THR A 1 245 ? 48.933 -24.579 -32.043 1.00 49.15  ? 226 THR A O   1 
ATOM   1764 C CB  . THR A 1 245 ? 48.264 -22.898 -34.493 1.00 37.58  ? 226 THR A CB  1 
ATOM   1765 O OG1 . THR A 1 245 ? 49.242 -21.885 -34.700 1.00 43.38  ? 226 THR A OG1 1 
ATOM   1766 C CG2 . THR A 1 245 ? 47.138 -22.716 -35.486 1.00 38.54  ? 226 THR A CG2 1 
ATOM   1767 N N   . ASP A 1 246 ? 49.668 -22.540 -31.484 1.00 38.89  ? 227 ASP A N   1 
ATOM   1768 C CA  . ASP A 1 246 ? 50.632 -22.985 -30.443 1.00 35.49  ? 227 ASP A CA  1 
ATOM   1769 C C   . ASP A 1 246 ? 50.669 -21.907 -29.365 1.00 33.11  ? 227 ASP A C   1 
ATOM   1770 O O   . ASP A 1 246 ? 50.018 -20.862 -29.545 1.00 34.67  ? 227 ASP A O   1 
ATOM   1771 C CB  . ASP A 1 246 ? 51.990 -23.332 -31.067 1.00 37.41  ? 227 ASP A CB  1 
ATOM   1772 C CG  . ASP A 1 246 ? 52.782 -22.146 -31.609 1.00 39.16  ? 227 ASP A CG  1 
ATOM   1773 O OD1 . ASP A 1 246 ? 52.591 -21.030 -31.117 1.00 40.06  ? 227 ASP A OD1 1 
ATOM   1774 O OD2 . ASP A 1 246 ? 53.597 -22.357 -32.514 1.00 43.36  ? 227 ASP A OD2 1 
ATOM   1775 N N   . HIS A 1 247 ? 51.430 -22.117 -28.302 1.00 33.50  ? 228 HIS A N   1 
ATOM   1776 C CA  . HIS A 1 247 ? 51.429 -21.218 -27.122 1.00 35.28  ? 228 HIS A CA  1 
ATOM   1777 C C   . HIS A 1 247 ? 51.850 -19.802 -27.533 1.00 37.19  ? 228 HIS A C   1 
ATOM   1778 O O   . HIS A 1 247 ? 51.316 -18.844 -26.934 1.00 37.48  ? 228 HIS A O   1 
ATOM   1779 C CB  . HIS A 1 247 ? 52.311 -21.762 -26.011 1.00 37.26  ? 228 HIS A CB  1 
ATOM   1780 C CG  . HIS A 1 247 ? 51.907 -23.107 -25.524 1.00 46.03  ? 228 HIS A CG  1 
ATOM   1781 N ND1 . HIS A 1 247 ? 51.963 -24.241 -26.335 1.00 52.72  ? 228 HIS A ND1 1 
ATOM   1782 C CD2 . HIS A 1 247 ? 51.502 -23.519 -24.301 1.00 46.18  ? 228 HIS A CD2 1 
ATOM   1783 C CE1 . HIS A 1 247 ? 51.574 -25.286 -25.625 1.00 53.69  ? 228 HIS A CE1 1 
ATOM   1784 N NE2 . HIS A 1 247 ? 51.285 -24.867 -24.376 1.00 49.12  ? 228 HIS A NE2 1 
ATOM   1785 N N   . ILE A 1 248 ? 52.777 -19.670 -28.495 1.00 32.71  ? 229 ILE A N   1 
ATOM   1786 C CA  . ILE A 1 248 ? 53.373 -18.357 -28.858 1.00 32.60  ? 229 ILE A CA  1 
ATOM   1787 C C   . ILE A 1 248 ? 52.335 -17.553 -29.639 1.00 32.60  ? 229 ILE A C   1 
ATOM   1788 O O   . ILE A 1 248 ? 52.127 -16.388 -29.261 1.00 31.28  ? 229 ILE A O   1 
ATOM   1789 C CB  . ILE A 1 248 ? 54.687 -18.525 -29.653 1.00 31.70  ? 229 ILE A CB  1 
ATOM   1790 C CG1 . ILE A 1 248 ? 55.734 -19.270 -28.830 1.00 29.86  ? 229 ILE A CG1 1 
ATOM   1791 C CG2 . ILE A 1 248 ? 55.216 -17.179 -30.153 1.00 32.85  ? 229 ILE A CG2 1 
ATOM   1792 C CD1 . ILE A 1 248 ? 56.116 -18.584 -27.560 1.00 30.38  ? 229 ILE A CD1 1 
ATOM   1793 N N   . ASP A 1 249 ? 51.815 -18.137 -30.731 1.00 34.23  ? 230 ASP A N   1 
ATOM   1794 C CA  . ASP A 1 249 ? 50.740 -17.570 -31.583 1.00 39.62  ? 230 ASP A CA  1 
ATOM   1795 C C   . ASP A 1 249 ? 49.558 -17.181 -30.677 1.00 38.83  ? 230 ASP A C   1 
ATOM   1796 O O   . ASP A 1 249 ? 49.066 -16.082 -30.806 1.00 38.04  ? 230 ASP A O   1 
ATOM   1797 C CB  . ASP A 1 249 ? 50.324 -18.540 -32.696 1.00 47.85  ? 230 ASP A CB  1 
ATOM   1798 C CG  . ASP A 1 249 ? 49.279 -17.969 -33.655 1.00 63.15  ? 230 ASP A CG  1 
ATOM   1799 O OD1 . ASP A 1 249 ? 49.245 -16.712 -33.833 1.00 70.60  ? 230 ASP A OD1 1 
ATOM   1800 O OD2 . ASP A 1 249 ? 48.477 -18.767 -34.220 1.00 61.70  ? 230 ASP A OD2 1 
ATOM   1801 N N   . GLN A 1 250 ? 49.159 -18.049 -29.753 1.00 38.79  ? 231 GLN A N   1 
ATOM   1802 C CA  . GLN A 1 250 ? 48.070 -17.805 -28.776 1.00 37.94  ? 231 GLN A CA  1 
ATOM   1803 C C   . GLN A 1 250 ? 48.421 -16.577 -27.938 1.00 34.93  ? 231 GLN A C   1 
ATOM   1804 O O   . GLN A 1 250 ? 47.585 -15.654 -27.820 1.00 33.72  ? 231 GLN A O   1 
ATOM   1805 C CB  . GLN A 1 250 ? 47.891 -19.056 -27.916 1.00 42.26  ? 231 GLN A CB  1 
ATOM   1806 C CG  . GLN A 1 250 ? 46.782 -18.982 -26.881 1.00 46.81  ? 231 GLN A CG  1 
ATOM   1807 C CD  . GLN A 1 250 ? 45.413 -18.981 -27.507 1.00 56.52  ? 231 GLN A CD  1 
ATOM   1808 O OE1 . GLN A 1 250 ? 45.240 -19.313 -28.678 1.00 57.20  ? 231 GLN A OE1 1 
ATOM   1809 N NE2 . GLN A 1 250 ? 44.421 -18.606 -26.716 1.00 62.08  ? 231 GLN A NE2 1 
ATOM   1810 N N   . LEU A 1 251 ? 49.621 -16.541 -27.362 1.00 30.66  ? 232 LEU A N   1 
ATOM   1811 C CA  . LEU A 1 251 ? 49.976 -15.416 -26.483 1.00 30.19  ? 232 LEU A CA  1 
ATOM   1812 C C   . LEU A 1 251 ? 49.992 -14.109 -27.287 1.00 32.23  ? 232 LEU A C   1 
ATOM   1813 O O   . LEU A 1 251 ? 49.628 -13.061 -26.726 1.00 28.94  ? 232 LEU A O   1 
ATOM   1814 C CB  . LEU A 1 251 ? 51.331 -15.669 -25.860 1.00 33.32  ? 232 LEU A CB  1 
ATOM   1815 C CG  . LEU A 1 251 ? 51.818 -14.521 -24.997 1.00 35.86  ? 232 LEU A CG  1 
ATOM   1816 C CD1 . LEU A 1 251 ? 50.959 -14.412 -23.752 1.00 38.77  ? 232 LEU A CD1 1 
ATOM   1817 C CD2 . LEU A 1 251 ? 53.273 -14.731 -24.634 1.00 40.39  ? 232 LEU A CD2 1 
ATOM   1818 N N   . LYS A 1 252 ? 50.418 -14.144 -28.541 1.00 27.38  ? 233 LYS A N   1 
ATOM   1819 C CA  . LYS A 1 252 ? 50.511 -12.888 -29.308 1.00 30.91  ? 233 LYS A CA  1 
ATOM   1820 C C   . LYS A 1 252 ? 49.094 -12.398 -29.622 1.00 30.45  ? 233 LYS A C   1 
ATOM   1821 O O   . LYS A 1 252 ? 48.864 -11.166 -29.595 1.00 27.76  ? 233 LYS A O   1 
ATOM   1822 C CB  . LYS A 1 252 ? 51.367 -13.062 -30.560 1.00 30.52  ? 233 LYS A CB  1 
ATOM   1823 C CG  . LYS A 1 252 ? 52.860 -13.129 -30.275 1.00 34.21  ? 233 LYS A CG  1 
ATOM   1824 C CD  . LYS A 1 252 ? 53.608 -13.554 -31.524 1.00 34.20  ? 233 LYS A CD  1 
ATOM   1825 C CE  . LYS A 1 252 ? 55.118 -13.557 -31.412 1.00 33.65  ? 233 LYS A CE  1 
ATOM   1826 N NZ  . LYS A 1 252 ? 55.688 -14.151 -32.646 1.00 36.19  ? 233 LYS A NZ  1 
ATOM   1827 N N   . LEU A 1 253 ? 48.173 -13.307 -29.923 1.00 28.64  ? 234 LEU A N   1 
ATOM   1828 C CA  . LEU A 1 253 ? 46.777 -12.895 -30.193 1.00 29.69  ? 234 LEU A CA  1 
ATOM   1829 C C   . LEU A 1 253 ? 46.229 -12.234 -28.925 1.00 31.18  ? 234 LEU A C   1 
ATOM   1830 O O   . LEU A 1 253 ? 45.560 -11.200 -29.020 1.00 34.58  ? 234 LEU A O   1 
ATOM   1831 C CB  . LEU A 1 253 ? 45.946 -14.110 -30.574 1.00 29.89  ? 234 LEU A CB  1 
ATOM   1832 C CG  . LEU A 1 253 ? 46.184 -14.660 -31.963 1.00 29.08  ? 234 LEU A CG  1 
ATOM   1833 C CD1 . LEU A 1 253 ? 45.342 -15.900 -32.168 1.00 30.85  ? 234 LEU A CD1 1 
ATOM   1834 C CD2 . LEU A 1 253 ? 45.850 -13.621 -33.006 1.00 33.53  ? 234 LEU A CD2 1 
ATOM   1835 N N   . ILE A 1 254 ? 46.474 -12.840 -27.773 1.00 31.57  ? 235 ILE A N   1 
ATOM   1836 C CA  . ILE A 1 254 ? 45.947 -12.299 -26.500 1.00 32.81  ? 235 ILE A CA  1 
ATOM   1837 C C   . ILE A 1 254 ? 46.557 -10.914 -26.271 1.00 37.40  ? 235 ILE A C   1 
ATOM   1838 O O   . ILE A 1 254 ? 45.796 -9.994  -25.956 1.00 34.97  ? 235 ILE A O   1 
ATOM   1839 C CB  . ILE A 1 254 ? 46.230 -13.227 -25.314 1.00 31.35  ? 235 ILE A CB  1 
ATOM   1840 C CG1 . ILE A 1 254 ? 45.415 -14.519 -25.401 1.00 34.96  ? 235 ILE A CG1 1 
ATOM   1841 C CG2 . ILE A 1 254 ? 45.943 -12.485 -24.023 1.00 32.85  ? 235 ILE A CG2 1 
ATOM   1842 C CD1 . ILE A 1 254 ? 45.906 -15.610 -24.485 1.00 33.16  ? 235 ILE A CD1 1 
ATOM   1843 N N   . LEU A 1 255 ? 47.883 -10.776 -26.371 1.00 37.73  ? 236 LEU A N   1 
ATOM   1844 C CA  . LEU A 1 255 ? 48.573 -9.507  -26.011 1.00 37.08  ? 236 LEU A CA  1 
ATOM   1845 C C   . LEU A 1 255 ? 48.191 -8.414  -27.020 1.00 35.55  ? 236 LEU A C   1 
ATOM   1846 O O   . LEU A 1 255 ? 48.164 -7.236  -26.626 1.00 36.14  ? 236 LEU A O   1 
ATOM   1847 C CB  . LEU A 1 255 ? 50.086 -9.734  -25.908 1.00 36.70  ? 236 LEU A CB  1 
ATOM   1848 C CG  . LEU A 1 255 ? 50.520 -10.676 -24.782 1.00 38.98  ? 236 LEU A CG  1 
ATOM   1849 C CD1 . LEU A 1 255 ? 52.037 -10.811 -24.715 1.00 39.95  ? 236 LEU A CD1 1 
ATOM   1850 C CD2 . LEU A 1 255 ? 49.998 -10.233 -23.434 1.00 37.72  ? 236 LEU A CD2 1 
ATOM   1851 N N   . ARG A 1 256 ? 47.818 -8.788  -28.242 1.00 35.51  ? 237 ARG A N   1 
ATOM   1852 C CA  . ARG A 1 256 ? 47.345 -7.821  -29.254 1.00 38.97  ? 237 ARG A CA  1 
ATOM   1853 C C   . ARG A 1 256 ? 46.046 -7.161  -28.764 1.00 41.24  ? 237 ARG A C   1 
ATOM   1854 O O   . ARG A 1 256 ? 45.875 -5.963  -29.054 1.00 42.70  ? 237 ARG A O   1 
ATOM   1855 C CB  . ARG A 1 256 ? 47.148 -8.531  -30.586 1.00 45.91  ? 237 ARG A CB  1 
ATOM   1856 C CG  . ARG A 1 256 ? 46.792 -7.599  -31.731 1.00 58.31  ? 237 ARG A CG  1 
ATOM   1857 C CD  . ARG A 1 256 ? 46.593 -8.364  -33.028 1.00 66.04  ? 237 ARG A CD  1 
ATOM   1858 N NE  . ARG A 1 256 ? 47.723 -9.252  -33.287 1.00 69.17  ? 237 ARG A NE  1 
ATOM   1859 C CZ  . ARG A 1 256 ? 47.706 -10.245 -34.171 1.00 71.45  ? 237 ARG A CZ  1 
ATOM   1860 N NH1 . ARG A 1 256 ? 46.613 -10.444 -34.889 1.00 68.19  ? 237 ARG A NH1 1 
ATOM   1861 N NH2 . ARG A 1 256 ? 48.764 -11.041 -34.309 1.00 62.11  ? 237 ARG A NH2 1 
ATOM   1862 N N   . LEU A 1 257 ? 45.183 -7.876  -28.027 1.00 35.97  ? 238 LEU A N   1 
ATOM   1863 C CA  . LEU A 1 257 ? 43.878 -7.327  -27.565 1.00 31.80  ? 238 LEU A CA  1 
ATOM   1864 C C   . LEU A 1 257 ? 44.060 -6.616  -26.236 1.00 31.96  ? 238 LEU A C   1 
ATOM   1865 O O   . LEU A 1 257 ? 43.523 -5.520  -26.107 1.00 33.26  ? 238 LEU A O   1 
ATOM   1866 C CB  . LEU A 1 257 ? 42.804 -8.410  -27.422 1.00 31.17  ? 238 LEU A CB  1 
ATOM   1867 C CG  . LEU A 1 257 ? 41.420 -7.899  -26.999 1.00 32.72  ? 238 LEU A CG  1 
ATOM   1868 C CD1 . LEU A 1 257 ? 40.770 -7.074  -28.094 1.00 30.36  ? 238 LEU A CD1 1 
ATOM   1869 C CD2 . LEU A 1 257 ? 40.507 -9.040  -26.593 1.00 31.62  ? 238 LEU A CD2 1 
ATOM   1870 N N   . VAL A 1 258 ? 44.752 -7.223  -25.278 1.00 30.14  ? 239 VAL A N   1 
ATOM   1871 C CA  . VAL A 1 258 ? 44.738 -6.731  -23.873 1.00 31.87  ? 239 VAL A CA  1 
ATOM   1872 C C   . VAL A 1 258 ? 46.003 -5.920  -23.567 1.00 33.60  ? 239 VAL A C   1 
ATOM   1873 O O   . VAL A 1 258 ? 46.056 -5.368  -22.473 1.00 37.04  ? 239 VAL A O   1 
ATOM   1874 C CB  . VAL A 1 258 ? 44.546 -7.880  -22.870 1.00 32.96  ? 239 VAL A CB  1 
ATOM   1875 C CG1 . VAL A 1 258 ? 43.312 -8.701  -23.186 1.00 33.68  ? 239 VAL A CG1 1 
ATOM   1876 C CG2 . VAL A 1 258 ? 45.766 -8.775  -22.773 1.00 36.28  ? 239 VAL A CG2 1 
ATOM   1877 N N   . GLY A 1 259 ? 46.956 -5.819  -24.499 1.00 35.40  ? 240 GLY A N   1 
ATOM   1878 C CA  . GLY A 1 259 ? 48.212 -5.077  -24.276 1.00 40.54  ? 240 GLY A CA  1 
ATOM   1879 C C   . GLY A 1 259 ? 49.285 -5.928  -23.612 1.00 40.83  ? 240 GLY A C   1 
ATOM   1880 O O   . GLY A 1 259 ? 48.935 -6.891  -22.908 1.00 39.99  ? 240 GLY A O   1 
ATOM   1881 N N   . THR A 1 260 ? 50.564 -5.591  -23.815 1.00 41.56  ? 241 THR A N   1 
ATOM   1882 C CA  . THR A 1 260 ? 51.704 -6.320  -23.186 1.00 39.24  ? 241 THR A CA  1 
ATOM   1883 C C   . THR A 1 260 ? 51.685 -6.050  -21.690 1.00 36.33  ? 241 THR A C   1 
ATOM   1884 O O   . THR A 1 260 ? 51.193 -5.024  -21.259 1.00 34.16  ? 241 THR A O   1 
ATOM   1885 C CB  . THR A 1 260 ? 53.037 -5.948  -23.833 1.00 39.99  ? 241 THR A CB  1 
ATOM   1886 O OG1 . THR A 1 260 ? 53.056 -4.524  -23.866 1.00 41.61  ? 241 THR A OG1 1 
ATOM   1887 C CG2 . THR A 1 260 ? 53.174 -6.510  -25.230 1.00 43.63  ? 241 THR A CG2 1 
ATOM   1888 N N   . PRO A 1 261 ? 52.199 -6.969  -20.853 1.00 37.63  ? 242 PRO A N   1 
ATOM   1889 C CA  . PRO A 1 261 ? 52.251 -6.750  -19.413 1.00 40.19  ? 242 PRO A CA  1 
ATOM   1890 C C   . PRO A 1 261 ? 52.966 -5.457  -19.009 1.00 46.82  ? 242 PRO A C   1 
ATOM   1891 O O   . PRO A 1 261 ? 54.012 -5.156  -19.554 1.00 41.24  ? 242 PRO A O   1 
ATOM   1892 C CB  . PRO A 1 261 ? 53.067 -7.950  -18.919 1.00 41.44  ? 242 PRO A CB  1 
ATOM   1893 C CG  . PRO A 1 261 ? 52.790 -9.038  -19.941 1.00 40.02  ? 242 PRO A CG  1 
ATOM   1894 C CD  . PRO A 1 261 ? 52.725 -8.286  -21.251 1.00 39.18  ? 242 PRO A CD  1 
ATOM   1895 N N   . GLY A 1 262 ? 52.354 -4.717  -18.088 1.00 56.15  ? 243 GLY A N   1 
ATOM   1896 C CA  . GLY A 1 262 ? 52.967 -3.561  -17.414 1.00 57.26  ? 243 GLY A CA  1 
ATOM   1897 C C   . GLY A 1 262 ? 53.954 -4.032  -16.367 1.00 58.62  ? 243 GLY A C   1 
ATOM   1898 O O   . GLY A 1 262 ? 53.856 -5.201  -15.940 1.00 60.48  ? 243 GLY A O   1 
ATOM   1899 N N   . ALA A 1 263 ? 54.879 -3.152  -15.988 1.00 60.97  ? 244 ALA A N   1 
ATOM   1900 C CA  . ALA A 1 263 ? 55.917 -3.371  -14.953 1.00 58.91  ? 244 ALA A CA  1 
ATOM   1901 C C   . ALA A 1 263 ? 55.328 -4.062  -13.711 1.00 54.35  ? 244 ALA A C   1 
ATOM   1902 O O   . ALA A 1 263 ? 55.995 -4.977  -13.212 1.00 57.76  ? 244 ALA A O   1 
ATOM   1903 C CB  . ALA A 1 263 ? 56.555 -2.048  -14.612 1.00 60.37  ? 244 ALA A CB  1 
ATOM   1904 N N   . GLU A 1 264 ? 54.139 -3.655  -13.235 1.00 55.82  ? 245 GLU A N   1 
ATOM   1905 C CA  . GLU A 1 264 ? 53.489 -4.196  -11.997 1.00 59.01  ? 245 GLU A CA  1 
ATOM   1906 C C   . GLU A 1 264 ? 53.218 -5.702  -12.146 1.00 54.77  ? 245 GLU A C   1 
ATOM   1907 O O   . GLU A 1 264 ? 53.503 -6.442  -11.194 1.00 55.47  ? 245 GLU A O   1 
ATOM   1908 C CB  . GLU A 1 264 ? 52.183 -3.461  -11.676 1.00 64.90  ? 245 GLU A CB  1 
ATOM   1909 C CG  . GLU A 1 264 ? 51.586 -3.834  -10.322 1.00 73.88  ? 245 GLU A CG  1 
ATOM   1910 C CD  . GLU A 1 264 ? 50.257 -3.180  -9.940  1.00 78.74  ? 245 GLU A CD  1 
ATOM   1911 O OE1 . GLU A 1 264 ? 49.732 -2.364  -10.720 1.00 74.06  ? 245 GLU A OE1 1 
ATOM   1912 O OE2 . GLU A 1 264 ? 49.729 -3.513  -8.855  1.00 84.70  ? 245 GLU A OE2 1 
ATOM   1913 N N   . LEU A 1 265 ? 52.687 -6.133  -13.296 1.00 47.86  ? 246 LEU A N   1 
ATOM   1914 C CA  . LEU A 1 265 ? 52.441 -7.567  -13.606 1.00 50.83  ? 246 LEU A CA  1 
ATOM   1915 C C   . LEU A 1 265 ? 53.771 -8.336  -13.726 1.00 49.87  ? 246 LEU A C   1 
ATOM   1916 O O   . LEU A 1 265 ? 53.842 -9.489  -13.236 1.00 48.21  ? 246 LEU A O   1 
ATOM   1917 C CB  . LEU A 1 265 ? 51.614 -7.673  -14.895 1.00 49.62  ? 246 LEU A CB  1 
ATOM   1918 C CG  . LEU A 1 265 ? 51.258 -9.104  -15.302 1.00 49.57  ? 246 LEU A CG  1 
ATOM   1919 C CD1 . LEU A 1 265 ? 50.484 -9.811  -14.193 1.00 54.62  ? 246 LEU A CD1 1 
ATOM   1920 C CD2 . LEU A 1 265 ? 50.451 -9.121  -16.580 1.00 48.62  ? 246 LEU A CD2 1 
ATOM   1921 N N   . LEU A 1 266 ? 54.786 -7.744  -14.371 1.00 52.73  ? 247 LEU A N   1 
ATOM   1922 C CA  . LEU A 1 266 ? 56.128 -8.368  -14.572 1.00 54.50  ? 247 LEU A CA  1 
ATOM   1923 C C   . LEU A 1 266 ? 56.750 -8.758  -13.231 1.00 48.43  ? 247 LEU A C   1 
ATOM   1924 O O   . LEU A 1 266 ? 57.341 -9.828  -13.182 1.00 53.82  ? 247 LEU A O   1 
ATOM   1925 C CB  . LEU A 1 266 ? 57.037 -7.410  -15.346 1.00 56.66  ? 247 LEU A CB  1 
ATOM   1926 C CG  . LEU A 1 266 ? 56.680 -7.287  -16.823 1.00 61.55  ? 247 LEU A CG  1 
ATOM   1927 C CD1 . LEU A 1 266 ? 57.406 -6.125  -17.498 1.00 64.65  ? 247 LEU A CD1 1 
ATOM   1928 C CD2 . LEU A 1 266 ? 56.986 -8.598  -17.525 1.00 66.37  ? 247 LEU A CD2 1 
ATOM   1929 N N   . LYS A 1 267 ? 56.580 -7.945  -12.188 1.00 51.43  ? 248 LYS A N   1 
ATOM   1930 C CA  . LYS A 1 267 ? 57.092 -8.246  -10.825 1.00 58.92  ? 248 LYS A CA  1 
ATOM   1931 C C   . LYS A 1 267 ? 56.499 -9.572  -10.329 1.00 52.61  ? 248 LYS A C   1 
ATOM   1932 O O   . LYS A 1 267 ? 57.180 -10.280 -9.567  1.00 52.97  ? 248 LYS A O   1 
ATOM   1933 C CB  . LYS A 1 267 ? 56.796 -7.075  -9.879  1.00 74.22  ? 248 LYS A CB  1 
ATOM   1934 C CG  . LYS A 1 267 ? 57.184 -7.282  -8.414  1.00 87.45  ? 248 LYS A CG  1 
ATOM   1935 C CD  . LYS A 1 267 ? 56.960 -6.061  -7.497  1.00 100.03 ? 248 LYS A CD  1 
ATOM   1936 C CE  . LYS A 1 267 ? 55.523 -5.562  -7.401  1.00 105.19 ? 248 LYS A CE  1 
ATOM   1937 N NZ  . LYS A 1 267 ? 54.615 -6.506  -6.696  1.00 95.72  ? 248 LYS A NZ  1 
ATOM   1938 N N   . LYS A 1 268 ? 55.286 -9.930  -10.747 1.00 55.27  ? 249 LYS A N   1 
ATOM   1939 C CA  . LYS A 1 268 ? 54.529 -11.058 -10.136 1.00 55.30  ? 249 LYS A CA  1 
ATOM   1940 C C   . LYS A 1 268 ? 54.821 -12.371 -10.869 1.00 57.98  ? 249 LYS A C   1 
ATOM   1941 O O   . LYS A 1 268 ? 54.332 -13.425 -10.398 1.00 62.14  ? 249 LYS A O   1 
ATOM   1942 C CB  . LYS A 1 268 ? 53.032 -10.741 -10.135 1.00 61.51  ? 249 LYS A CB  1 
ATOM   1943 C CG  . LYS A 1 268 ? 52.659 -9.421  -9.473  1.00 63.96  ? 249 LYS A CG  1 
ATOM   1944 C CD  . LYS A 1 268 ? 51.176 -9.135  -9.532  1.00 69.73  ? 249 LYS A CD  1 
ATOM   1945 C CE  . LYS A 1 268 ? 50.802 -7.732  -9.104  1.00 67.22  ? 249 LYS A CE  1 
ATOM   1946 N NZ  . LYS A 1 268 ? 49.396 -7.432  -9.464  1.00 65.64  ? 249 LYS A NZ  1 
ATOM   1947 N N   . ILE A 1 269 ? 55.585 -12.319 -11.964 1.00 56.77  ? 250 ILE A N   1 
ATOM   1948 C CA  . ILE A 1 269 ? 55.973 -13.514 -12.771 1.00 57.17  ? 250 ILE A CA  1 
ATOM   1949 C C   . ILE A 1 269 ? 57.284 -14.088 -12.227 1.00 57.58  ? 250 ILE A C   1 
ATOM   1950 O O   . ILE A 1 269 ? 58.305 -13.412 -12.359 1.00 60.48  ? 250 ILE A O   1 
ATOM   1951 C CB  . ILE A 1 269 ? 56.062 -13.146 -14.265 1.00 53.68  ? 250 ILE A CB  1 
ATOM   1952 C CG1 . ILE A 1 269 ? 54.685 -12.751 -14.799 1.00 47.88  ? 250 ILE A CG1 1 
ATOM   1953 C CG2 . ILE A 1 269 ? 56.692 -14.274 -15.073 1.00 51.88  ? 250 ILE A CG2 1 
ATOM   1954 C CD1 . ILE A 1 269 ? 54.685 -12.275 -16.217 1.00 49.91  ? 250 ILE A CD1 1 
ATOM   1955 N N   . SER A 1 270 ? 57.229 -15.319 -11.711 1.00 66.64  ? 251 SER A N   1 
ATOM   1956 C CA  . SER A 1 270 ? 58.291 -16.023 -10.937 1.00 76.50  ? 251 SER A CA  1 
ATOM   1957 C C   . SER A 1 270 ? 59.505 -16.387 -11.813 1.00 76.16  ? 251 SER A C   1 
ATOM   1958 O O   . SER A 1 270 ? 60.657 -16.203 -11.343 1.00 76.36  ? 251 SER A O   1 
ATOM   1959 C CB  . SER A 1 270 ? 57.693 -17.243 -10.263 1.00 86.21  ? 251 SER A CB  1 
ATOM   1960 O OG  . SER A 1 270 ? 58.691 -18.055 -9.667  1.00 92.44  ? 251 SER A OG  1 
ATOM   1961 N N   . SER A 1 271 ? 59.276 -16.914 -13.021 1.00 67.98  ? 252 SER A N   1 
ATOM   1962 C CA  . SER A 1 271 ? 60.352 -17.332 -13.963 1.00 63.63  ? 252 SER A CA  1 
ATOM   1963 C C   . SER A 1 271 ? 61.109 -16.100 -14.489 1.00 66.24  ? 252 SER A C   1 
ATOM   1964 O O   . SER A 1 271 ? 60.452 -15.157 -14.946 1.00 69.22  ? 252 SER A O   1 
ATOM   1965 C CB  . SER A 1 271 ? 59.767 -18.144 -15.095 1.00 63.97  ? 252 SER A CB  1 
ATOM   1966 O OG  . SER A 1 271 ? 60.717 -18.370 -16.124 1.00 61.62  ? 252 SER A OG  1 
ATOM   1967 N N   . GLU A 1 272 ? 62.443 -16.095 -14.448 1.00 63.60  ? 253 GLU A N   1 
ATOM   1968 C CA  . GLU A 1 272 ? 63.248 -15.023 -15.092 1.00 61.76  ? 253 GLU A CA  1 
ATOM   1969 C C   . GLU A 1 272 ? 63.145 -15.178 -16.614 1.00 60.45  ? 253 GLU A C   1 
ATOM   1970 O O   . GLU A 1 272 ? 63.128 -14.145 -17.314 1.00 61.97  ? 253 GLU A O   1 
ATOM   1971 C CB  . GLU A 1 272 ? 64.710 -15.055 -14.635 1.00 66.33  ? 253 GLU A CB  1 
ATOM   1972 C CG  . GLU A 1 272 ? 65.549 -13.922 -15.223 1.00 71.02  ? 253 GLU A CG  1 
ATOM   1973 C CD  . GLU A 1 272 ? 67.018 -13.880 -14.814 1.00 73.56  ? 253 GLU A CD  1 
ATOM   1974 O OE1 . GLU A 1 272 ? 67.439 -14.771 -14.033 1.00 66.30  ? 253 GLU A OE1 1 
ATOM   1975 O OE2 . GLU A 1 272 ? 67.747 -12.967 -15.295 1.00 71.35  ? 253 GLU A OE2 1 
ATOM   1976 N N   . SER A 1 273 ? 63.099 -16.417 -17.117 1.00 58.25  ? 254 SER A N   1 
ATOM   1977 C CA  . SER A 1 273 ? 63.080 -16.711 -18.576 1.00 54.13  ? 254 SER A CA  1 
ATOM   1978 C C   . SER A 1 273 ? 61.787 -16.153 -19.173 1.00 48.66  ? 254 SER A C   1 
ATOM   1979 O O   . SER A 1 273 ? 61.860 -15.543 -20.249 1.00 51.95  ? 254 SER A O   1 
ATOM   1980 C CB  . SER A 1 273 ? 63.232 -18.185 -18.889 1.00 55.68  ? 254 SER A CB  1 
ATOM   1981 O OG  . SER A 1 273 ? 63.438 -18.402 -20.295 1.00 57.57  ? 254 SER A OG  1 
ATOM   1982 N N   . ALA A 1 274 ? 60.654 -16.374 -18.507 1.00 49.46  ? 255 ALA A N   1 
ATOM   1983 C CA  . ALA A 1 274 ? 59.321 -15.904 -18.960 1.00 54.79  ? 255 ALA A CA  1 
ATOM   1984 C C   . ALA A 1 274 ? 59.324 -14.372 -18.955 1.00 53.71  ? 255 ALA A C   1 
ATOM   1985 O O   . ALA A 1 274 ? 58.895 -13.764 -19.949 1.00 51.84  ? 255 ALA A O   1 
ATOM   1986 C CB  . ALA A 1 274 ? 58.230 -16.457 -18.079 1.00 54.96  ? 255 ALA A CB  1 
ATOM   1987 N N   . ARG A 1 275 ? 59.851 -13.793 -17.878 1.00 54.53  ? 256 ARG A N   1 
ATOM   1988 C CA  . ARG A 1 275 ? 60.005 -12.323 -17.704 1.00 56.91  ? 256 ARG A CA  1 
ATOM   1989 C C   . ARG A 1 275 ? 60.876 -11.775 -18.849 1.00 54.09  ? 256 ARG A C   1 
ATOM   1990 O O   . ARG A 1 275 ? 60.463 -10.772 -19.501 1.00 48.42  ? 256 ARG A O   1 
ATOM   1991 C CB  . ARG A 1 275 ? 60.548 -12.036 -16.300 1.00 55.53  ? 256 ARG A CB  1 
ATOM   1992 C CG  . ARG A 1 275 ? 60.344 -10.601 -15.845 1.00 63.13  ? 256 ARG A CG  1 
ATOM   1993 C CD  . ARG A 1 275 ? 60.451 -10.452 -14.337 1.00 64.33  ? 256 ARG A CD  1 
ATOM   1994 N NE  . ARG A 1 275 ? 61.724 -10.948 -13.825 1.00 65.76  ? 256 ARG A NE  1 
ATOM   1995 C CZ  . ARG A 1 275 ? 61.878 -12.009 -13.045 1.00 62.73  ? 256 ARG A CZ  1 
ATOM   1996 N NH1 . ARG A 1 275 ? 60.827 -12.703 -12.645 1.00 72.20  ? 256 ARG A NH1 1 
ATOM   1997 N NH2 . ARG A 1 275 ? 63.086 -12.370 -12.652 1.00 60.72  ? 256 ARG A NH2 1 
ATOM   1998 N N   . ASN A 1 276 ? 62.019 -12.420 -19.112 1.00 48.84  ? 257 ASN A N   1 
ATOM   1999 C CA  . ASN A 1 276 ? 62.946 -12.027 -20.199 1.00 48.92  ? 257 ASN A CA  1 
ATOM   2000 C C   . ASN A 1 276 ? 62.211 -12.090 -21.522 1.00 41.15  ? 257 ASN A C   1 
ATOM   2001 O O   . ASN A 1 276 ? 62.414 -11.186 -22.339 1.00 41.70  ? 257 ASN A O   1 
ATOM   2002 C CB  . ASN A 1 276 ? 64.180 -12.924 -20.279 1.00 58.28  ? 257 ASN A CB  1 
ATOM   2003 C CG  . ASN A 1 276 ? 65.287 -12.418 -19.390 1.00 63.06  ? 257 ASN A CG  1 
ATOM   2004 O OD1 . ASN A 1 276 ? 65.611 -13.022 -18.366 1.00 69.20  ? 257 ASN A OD1 1 
ATOM   2005 N ND2 . ASN A 1 276 ? 65.835 -11.277 -19.766 1.00 63.11  ? 257 ASN A ND2 1 
ATOM   2006 N N   . TYR A 1 277 ? 61.446 -13.161 -21.741 1.00 39.47  ? 258 TYR A N   1 
ATOM   2007 C CA  . TYR A 1 277 ? 60.729 -13.368 -23.022 1.00 38.81  ? 258 TYR A CA  1 
ATOM   2008 C C   . TYR A 1 277 ? 59.735 -12.211 -23.197 1.00 42.08  ? 258 TYR A C   1 
ATOM   2009 O O   . TYR A 1 277 ? 59.712 -11.598 -24.282 1.00 42.06  ? 258 TYR A O   1 
ATOM   2010 C CB  . TYR A 1 277 ? 60.017 -14.722 -23.113 1.00 36.17  ? 258 TYR A CB  1 
ATOM   2011 C CG  . TYR A 1 277 ? 59.214 -14.808 -24.381 1.00 33.45  ? 258 TYR A CG  1 
ATOM   2012 C CD1 . TYR A 1 277 ? 59.834 -14.595 -25.596 1.00 32.81  ? 258 TYR A CD1 1 
ATOM   2013 C CD2 . TYR A 1 277 ? 57.841 -14.985 -24.383 1.00 35.22  ? 258 TYR A CD2 1 
ATOM   2014 C CE1 . TYR A 1 277 ? 59.119 -14.611 -26.778 1.00 33.89  ? 258 TYR A CE1 1 
ATOM   2015 C CE2 . TYR A 1 277 ? 57.108 -15.000 -25.567 1.00 32.38  ? 258 TYR A CE2 1 
ATOM   2016 C CZ  . TYR A 1 277 ? 57.751 -14.806 -26.773 1.00 31.82  ? 258 TYR A CZ  1 
ATOM   2017 O OH  . TYR A 1 277 ? 57.117 -14.805 -27.988 1.00 29.26  ? 258 TYR A OH  1 
ATOM   2018 N N   . ILE A 1 278 ? 58.954 -11.903 -22.160 1.00 43.69  ? 259 ILE A N   1 
ATOM   2019 C CA  . ILE A 1 278 ? 57.911 -10.837 -22.229 1.00 49.58  ? 259 ILE A CA  1 
ATOM   2020 C C   . ILE A 1 278 ? 58.567 -9.494  -22.551 1.00 46.16  ? 259 ILE A C   1 
ATOM   2021 O O   . ILE A 1 278 ? 58.059 -8.801  -23.436 1.00 48.26  ? 259 ILE A O   1 
ATOM   2022 C CB  . ILE A 1 278 ? 57.093 -10.768 -20.931 1.00 53.51  ? 259 ILE A CB  1 
ATOM   2023 C CG1 . ILE A 1 278 ? 56.208 -12.005 -20.771 1.00 50.58  ? 259 ILE A CG1 1 
ATOM   2024 C CG2 . ILE A 1 278 ? 56.267 -9.484  -20.889 1.00 58.13  ? 259 ILE A CG2 1 
ATOM   2025 C CD1 . ILE A 1 278 ? 55.872 -12.288 -19.329 1.00 55.70  ? 259 ILE A CD1 1 
ATOM   2026 N N   . GLN A 1 279 ? 59.668 -9.169  -21.876 1.00 51.55  ? 260 GLN A N   1 
ATOM   2027 C CA  . GLN A 1 279 ? 60.456 -7.926  -22.111 1.00 52.27  ? 260 GLN A CA  1 
ATOM   2028 C C   . GLN A 1 279 ? 60.962 -7.884  -23.551 1.00 48.08  ? 260 GLN A C   1 
ATOM   2029 O O   . GLN A 1 279 ? 61.065 -6.793  -24.097 1.00 55.84  ? 260 GLN A O   1 
ATOM   2030 C CB  . GLN A 1 279 ? 61.625 -7.842  -21.141 1.00 58.33  ? 260 GLN A CB  1 
ATOM   2031 C CG  . GLN A 1 279 ? 61.181 -7.591  -19.711 1.00 61.98  ? 260 GLN A CG  1 
ATOM   2032 C CD  . GLN A 1 279 ? 62.286 -7.913  -18.736 1.00 69.12  ? 260 GLN A CD  1 
ATOM   2033 O OE1 . GLN A 1 279 ? 63.342 -8.427  -19.103 1.00 71.53  ? 260 GLN A OE1 1 
ATOM   2034 N NE2 . GLN A 1 279 ? 62.037 -7.620  -17.474 1.00 73.35  ? 260 GLN A NE2 1 
ATOM   2035 N N   . SER A 1 280 ? 61.190 -9.030  -24.174 1.00 45.46  ? 261 SER A N   1 
ATOM   2036 C CA  . SER A 1 280 ? 61.649 -9.104  -25.579 1.00 43.72  ? 261 SER A CA  1 
ATOM   2037 C C   . SER A 1 280 ? 60.569 -8.619  -26.548 1.00 46.19  ? 261 SER A C   1 
ATOM   2038 O O   . SER A 1 280 ? 60.917 -8.358  -27.722 1.00 44.14  ? 261 SER A O   1 
ATOM   2039 C CB  . SER A 1 280 ? 62.077 -10.503 -25.927 1.00 46.40  ? 261 SER A CB  1 
ATOM   2040 O OG  . SER A 1 280 ? 60.963 -11.298 -26.302 1.00 43.52  ? 261 SER A OG  1 
ATOM   2041 N N   . LEU A 1 281 ? 59.299 -8.597  -26.131 1.00 45.53  ? 262 LEU A N   1 
ATOM   2042 C CA  . LEU A 1 281 ? 58.169 -8.311  -27.056 1.00 45.66  ? 262 LEU A CA  1 
ATOM   2043 C C   . LEU A 1 281 ? 58.045 -6.800  -27.252 1.00 48.42  ? 262 LEU A C   1 
ATOM   2044 O O   . LEU A 1 281 ? 58.165 -6.076  -26.257 1.00 48.19  ? 262 LEU A O   1 
ATOM   2045 C CB  . LEU A 1 281 ? 56.875 -8.898  -26.493 1.00 45.67  ? 262 LEU A CB  1 
ATOM   2046 C CG  . LEU A 1 281 ? 56.860 -10.417 -26.332 1.00 47.79  ? 262 LEU A CG  1 
ATOM   2047 C CD1 . LEU A 1 281 ? 55.613 -10.865 -25.586 1.00 47.20  ? 262 LEU A CD1 1 
ATOM   2048 C CD2 . LEU A 1 281 ? 56.969 -11.123 -27.681 1.00 47.44  ? 262 LEU A CD2 1 
ATOM   2049 N N   . ALA A 1 282 ? 57.807 -6.357  -28.487 1.00 51.10  ? 263 ALA A N   1 
ATOM   2050 C CA  . ALA A 1 282 ? 57.346 -4.978  -28.784 1.00 59.47  ? 263 ALA A CA  1 
ATOM   2051 C C   . ALA A 1 282 ? 56.156 -4.672  -27.863 1.00 58.23  ? 263 ALA A C   1 
ATOM   2052 O O   . ALA A 1 282 ? 55.165 -5.439  -27.932 1.00 48.56  ? 263 ALA A O   1 
ATOM   2053 C CB  . ALA A 1 282 ? 56.961 -4.842  -30.244 1.00 62.95  ? 263 ALA A CB  1 
ATOM   2054 N N   . GLN A 1 283 ? 56.305 -3.668  -26.987 1.00 59.42  ? 264 GLN A N   1 
ATOM   2055 C CA  . GLN A 1 283 ? 55.234 -3.136  -26.105 1.00 66.02  ? 264 GLN A CA  1 
ATOM   2056 C C   . GLN A 1 283 ? 54.031 -2.811  -26.998 1.00 68.23  ? 264 GLN A C   1 
ATOM   2057 O O   . GLN A 1 283 ? 54.236 -2.231  -28.077 1.00 65.88  ? 264 GLN A O   1 
ATOM   2058 C CB  . GLN A 1 283 ? 55.722 -1.911  -25.324 1.00 71.56  ? 264 GLN A CB  1 
ATOM   2059 C CG  . GLN A 1 283 ? 54.847 -1.523  -24.128 1.00 83.87  ? 264 GLN A CG  1 
ATOM   2060 C CD  . GLN A 1 283 ? 53.740 -0.530  -24.429 1.00 92.20  ? 264 GLN A CD  1 
ATOM   2061 O OE1 . GLN A 1 283 ? 53.859 0.337   -25.294 1.00 95.77  ? 264 GLN A OE1 1 
ATOM   2062 N NE2 . GLN A 1 283 ? 52.641 -0.624  -23.695 1.00 89.81  ? 264 GLN A NE2 1 
ATOM   2063 N N   . MET A 1 284 ? 52.832 -3.231  -26.597 1.00 64.46  ? 265 MET A N   1 
ATOM   2064 C CA  . MET A 1 284 ? 51.579 -2.974  -27.353 1.00 63.55  ? 265 MET A CA  1 
ATOM   2065 C C   . MET A 1 284 ? 50.570 -2.350  -26.400 1.00 54.66  ? 265 MET A C   1 
ATOM   2066 O O   . MET A 1 284 ? 50.532 -2.655  -25.209 1.00 43.98  ? 265 MET A O   1 
ATOM   2067 C CB  . MET A 1 284 ? 51.003 -4.256  -27.961 1.00 70.36  ? 265 MET A CB  1 
ATOM   2068 C CG  . MET A 1 284 ? 51.902 -4.871  -29.031 1.00 78.07  ? 265 MET A CG  1 
ATOM   2069 S SD  . MET A 1 284 ? 51.250 -6.415  -29.755 1.00 79.80  ? 265 MET A SD  1 
ATOM   2070 C CE  . MET A 1 284 ? 51.383 -7.541  -28.370 1.00 73.56  ? 265 MET A CE  1 
ATOM   2071 N N   . PRO A 1 285 ? 49.719 -1.429  -26.894 1.00 59.41  ? 266 PRO A N   1 
ATOM   2072 C CA  . PRO A 1 285 ? 48.667 -0.867  -26.055 1.00 55.67  ? 266 PRO A CA  1 
ATOM   2073 C C   . PRO A 1 285 ? 47.487 -1.855  -26.024 1.00 49.44  ? 266 PRO A C   1 
ATOM   2074 O O   . PRO A 1 285 ? 47.253 -2.565  -27.007 1.00 44.11  ? 266 PRO A O   1 
ATOM   2075 C CB  . PRO A 1 285 ? 48.350 0.438   -26.787 1.00 55.88  ? 266 PRO A CB  1 
ATOM   2076 C CG  . PRO A 1 285 ? 48.496 0.042   -28.261 1.00 58.33  ? 266 PRO A CG  1 
ATOM   2077 C CD  . PRO A 1 285 ? 49.667 -0.927  -28.282 1.00 59.64  ? 266 PRO A CD  1 
ATOM   2078 N N   . LYS A 1 286 ? 46.795 -1.899  -24.890 1.00 46.42  ? 267 LYS A N   1 
ATOM   2079 C CA  . LYS A 1 286 ? 45.420 -2.430  -24.795 1.00 52.70  ? 267 LYS A CA  1 
ATOM   2080 C C   . LYS A 1 286 ? 44.588 -1.828  -25.932 1.00 53.62  ? 267 LYS A C   1 
ATOM   2081 O O   . LYS A 1 286 ? 44.713 -0.619  -26.184 1.00 50.30  ? 267 LYS A O   1 
ATOM   2082 C CB  . LYS A 1 286 ? 44.805 -2.060  -23.450 1.00 54.36  ? 267 LYS A CB  1 
ATOM   2083 C CG  . LYS A 1 286 ? 43.394 -2.567  -23.263 1.00 57.89  ? 267 LYS A CG  1 
ATOM   2084 C CD  . LYS A 1 286 ? 42.836 -2.220  -21.923 1.00 62.76  ? 267 LYS A CD  1 
ATOM   2085 C CE  . LYS A 1 286 ? 41.362 -2.532  -21.850 1.00 66.30  ? 267 LYS A CE  1 
ATOM   2086 N NZ  . LYS A 1 286 ? 40.592 -1.633  -22.738 1.00 66.75  ? 267 LYS A NZ  1 
ATOM   2087 N N   . MET A 1 287 ? 43.781 -2.639  -26.604 1.00 46.53  ? 268 MET A N   1 
ATOM   2088 C CA  . MET A 1 287 ? 42.847 -2.133  -27.638 1.00 44.52  ? 268 MET A CA  1 
ATOM   2089 C C   . MET A 1 287 ? 41.564 -1.611  -26.972 1.00 40.82  ? 268 MET A C   1 
ATOM   2090 O O   . MET A 1 287 ? 41.214 -2.026  -25.847 1.00 35.44  ? 268 MET A O   1 
ATOM   2091 C CB  . MET A 1 287 ? 42.513 -3.225  -28.663 1.00 47.26  ? 268 MET A CB  1 
ATOM   2092 C CG  . MET A 1 287 ? 43.659 -3.507  -29.631 1.00 51.63  ? 268 MET A CG  1 
ATOM   2093 S SD  . MET A 1 287 ? 43.348 -4.922  -30.735 1.00 55.13  ? 268 MET A SD  1 
ATOM   2094 C CE  . MET A 1 287 ? 42.016 -4.263  -31.739 1.00 61.84  ? 268 MET A CE  1 
ATOM   2095 N N   . ASN A 1 288 ? 40.855 -0.743  -27.687 1.00 41.57  ? 269 ASN A N   1 
ATOM   2096 C CA  . ASN A 1 288 ? 39.481 -0.316  -27.339 1.00 38.41  ? 269 ASN A CA  1 
ATOM   2097 C C   . ASN A 1 288 ? 38.556 -1.474  -27.734 1.00 34.11  ? 269 ASN A C   1 
ATOM   2098 O O   . ASN A 1 288 ? 38.454 -1.742  -28.931 1.00 36.47  ? 269 ASN A O   1 
ATOM   2099 C CB  . ASN A 1 288 ? 39.176 1.017   -28.031 1.00 41.58  ? 269 ASN A CB  1 
ATOM   2100 C CG  . ASN A 1 288 ? 37.756 1.507   -27.821 1.00 48.99  ? 269 ASN A CG  1 
ATOM   2101 O OD1 . ASN A 1 288 ? 36.888 0.792   -27.304 1.00 41.15  ? 269 ASN A OD1 1 
ATOM   2102 N ND2 . ASN A 1 288 ? 37.498 2.732   -28.245 1.00 50.79  ? 269 ASN A ND2 1 
ATOM   2103 N N   . PHE A 1 289 ? 37.902 -2.135  -26.776 1.00 34.22  ? 270 PHE A N   1 
ATOM   2104 C CA  . PHE A 1 289 ? 37.053 -3.325  -27.056 1.00 35.94  ? 270 PHE A CA  1 
ATOM   2105 C C   . PHE A 1 289 ? 35.834 -2.922  -27.877 1.00 35.20  ? 270 PHE A C   1 
ATOM   2106 O O   . PHE A 1 289 ? 35.363 -3.745  -28.674 1.00 34.63  ? 270 PHE A O   1 
ATOM   2107 C CB  . PHE A 1 289 ? 36.553 -4.024  -25.788 1.00 34.83  ? 270 PHE A CB  1 
ATOM   2108 C CG  . PHE A 1 289 ? 37.521 -4.982  -25.152 1.00 32.05  ? 270 PHE A CG  1 
ATOM   2109 C CD1 . PHE A 1 289 ? 38.891 -4.775  -25.220 1.00 36.95  ? 270 PHE A CD1 1 
ATOM   2110 C CD2 . PHE A 1 289 ? 37.054 -6.079  -24.448 1.00 30.82  ? 270 PHE A CD2 1 
ATOM   2111 C CE1 . PHE A 1 289 ? 39.776 -5.654  -24.604 1.00 37.58  ? 270 PHE A CE1 1 
ATOM   2112 C CE2 . PHE A 1 289 ? 37.936 -6.959  -23.846 1.00 33.53  ? 270 PHE A CE2 1 
ATOM   2113 C CZ  . PHE A 1 289 ? 39.293 -6.735  -23.903 1.00 37.89  ? 270 PHE A CZ  1 
ATOM   2114 N N   . ALA A 1 290 ? 35.294 -1.726  -27.660 1.00 35.66  ? 271 ALA A N   1 
ATOM   2115 C CA  . ALA A 1 290 ? 34.026 -1.324  -28.321 1.00 39.35  ? 271 ALA A CA  1 
ATOM   2116 C C   . ALA A 1 290 ? 34.191 -1.436  -29.839 1.00 40.01  ? 271 ALA A C   1 
ATOM   2117 O O   . ALA A 1 290 ? 33.196 -1.760  -30.509 1.00 43.06  ? 271 ALA A O   1 
ATOM   2118 C CB  . ALA A 1 290 ? 33.606 0.066   -27.904 1.00 40.14  ? 271 ALA A CB  1 
ATOM   2119 N N   . ASN A 1 291 ? 35.407 -1.203  -30.345 1.00 43.27  ? 272 ASN A N   1 
ATOM   2120 C CA  . ASN A 1 291 ? 35.747 -1.268  -31.793 1.00 49.98  ? 272 ASN A CA  1 
ATOM   2121 C C   . ASN A 1 291 ? 35.976 -2.716  -32.243 1.00 48.44  ? 272 ASN A C   1 
ATOM   2122 O O   . ASN A 1 291 ? 36.099 -2.920  -33.431 1.00 61.65  ? 272 ASN A O   1 
ATOM   2123 C CB  . ASN A 1 291 ? 37.006 -0.451  -32.124 1.00 54.22  ? 272 ASN A CB  1 
ATOM   2124 C CG  . ASN A 1 291 ? 36.853 1.041   -31.885 1.00 54.55  ? 272 ASN A CG  1 
ATOM   2125 O OD1 . ASN A 1 291 ? 35.789 1.621   -32.095 1.00 50.03  ? 272 ASN A OD1 1 
ATOM   2126 N ND2 . ASN A 1 291 ? 37.908 1.665   -31.391 1.00 56.13  ? 272 ASN A ND2 1 
ATOM   2127 N N   . VAL A 1 292 ? 36.121 -3.674  -31.338 1.00 45.82  ? 273 VAL A N   1 
ATOM   2128 C CA  . VAL A 1 292 ? 36.298 -5.116  -31.683 1.00 41.83  ? 273 VAL A CA  1 
ATOM   2129 C C   . VAL A 1 292 ? 34.926 -5.790  -31.652 1.00 41.38  ? 273 VAL A C   1 
ATOM   2130 O O   . VAL A 1 292 ? 34.808 -6.850  -32.265 1.00 46.13  ? 273 VAL A O   1 
ATOM   2131 C CB  . VAL A 1 292 ? 37.281 -5.799  -30.716 1.00 47.15  ? 273 VAL A CB  1 
ATOM   2132 C CG1 . VAL A 1 292 ? 37.368 -7.312  -30.905 1.00 53.19  ? 273 VAL A CG1 1 
ATOM   2133 C CG2 . VAL A 1 292 ? 38.662 -5.180  -30.806 1.00 51.96  ? 273 VAL A CG2 1 
ATOM   2134 N N   . PHE A 1 293 ? 33.930 -5.182  -30.986 1.00 42.14  ? 274 PHE A N   1 
ATOM   2135 C CA  . PHE A 1 293 ? 32.595 -5.777  -30.699 1.00 37.50  ? 274 PHE A CA  1 
ATOM   2136 C C   . PHE A 1 293 ? 31.458 -4.819  -31.066 1.00 36.02  ? 274 PHE A C   1 
ATOM   2137 O O   . PHE A 1 293 ? 30.388 -4.852  -30.414 1.00 37.61  ? 274 PHE A O   1 
ATOM   2138 C CB  . PHE A 1 293 ? 32.480 -6.176  -29.224 1.00 37.46  ? 274 PHE A CB  1 
ATOM   2139 C CG  . PHE A 1 293 ? 33.460 -7.236  -28.802 1.00 34.37  ? 274 PHE A CG  1 
ATOM   2140 C CD1 . PHE A 1 293 ? 33.190 -8.572  -29.027 1.00 33.98  ? 274 PHE A CD1 1 
ATOM   2141 C CD2 . PHE A 1 293 ? 34.667 -6.895  -28.210 1.00 32.65  ? 274 PHE A CD2 1 
ATOM   2142 C CE1 . PHE A 1 293 ? 34.118 -9.549  -28.682 1.00 33.53  ? 274 PHE A CE1 1 
ATOM   2143 C CE2 . PHE A 1 293 ? 35.582 -7.867  -27.842 1.00 33.94  ? 274 PHE A CE2 1 
ATOM   2144 C CZ  . PHE A 1 293 ? 35.318 -9.197  -28.113 1.00 35.52  ? 274 PHE A CZ  1 
ATOM   2145 N N   . ILE A 1 294 ? 31.580 -4.081  -32.161 1.00 36.24  ? 275 ILE A N   1 
ATOM   2146 C CA  . ILE A 1 294 ? 30.483 -3.157  -32.570 1.00 40.45  ? 275 ILE A CA  1 
ATOM   2147 C C   . ILE A 1 294 ? 29.189 -3.964  -32.695 1.00 36.90  ? 275 ILE A C   1 
ATOM   2148 O O   . ILE A 1 294 ? 29.227 -5.063  -33.286 1.00 39.90  ? 275 ILE A O   1 
ATOM   2149 C CB  . ILE A 1 294 ? 30.788 -2.381  -33.873 1.00 50.32  ? 275 ILE A CB  1 
ATOM   2150 C CG1 . ILE A 1 294 ? 32.150 -1.685  -33.839 1.00 53.81  ? 275 ILE A CG1 1 
ATOM   2151 C CG2 . ILE A 1 294 ? 29.663 -1.395  -34.180 1.00 51.80  ? 275 ILE A CG2 1 
ATOM   2152 C CD1 . ILE A 1 294 ? 33.296 -2.592  -34.269 1.00 58.62  ? 275 ILE A CD1 1 
ATOM   2153 N N   . GLY A 1 295 ? 28.091 -3.413  -32.173 1.00 35.88  ? 276 GLY A N   1 
ATOM   2154 C CA  . GLY A 1 295 ? 26.722 -3.947  -32.293 1.00 33.75  ? 276 GLY A CA  1 
ATOM   2155 C C   . GLY A 1 295 ? 26.380 -4.926  -31.186 1.00 32.95  ? 276 GLY A C   1 
ATOM   2156 O O   . GLY A 1 295 ? 25.207 -5.350  -31.126 1.00 33.46  ? 276 GLY A O   1 
ATOM   2157 N N   . ALA A 1 296 ? 27.360 -5.341  -30.364 1.00 34.91  ? 277 ALA A N   1 
ATOM   2158 C CA  . ALA A 1 296 ? 27.085 -6.128  -29.135 1.00 33.88  ? 277 ALA A CA  1 
ATOM   2159 C C   . ALA A 1 296 ? 26.480 -5.183  -28.084 1.00 31.45  ? 277 ALA A C   1 
ATOM   2160 O O   . ALA A 1 296 ? 26.816 -3.981  -28.070 1.00 29.58  ? 277 ALA A O   1 
ATOM   2161 C CB  . ALA A 1 296 ? 28.330 -6.797  -28.619 1.00 33.49  ? 277 ALA A CB  1 
ATOM   2162 N N   . ASN A 1 297 ? 25.586 -5.691  -27.252 1.00 29.93  ? 278 ASN A N   1 
ATOM   2163 C CA  . ASN A 1 297 ? 25.128 -4.957  -26.042 1.00 30.12  ? 278 ASN A CA  1 
ATOM   2164 C C   . ASN A 1 297 ? 26.348 -4.323  -25.365 1.00 28.41  ? 278 ASN A C   1 
ATOM   2165 O O   . ASN A 1 297 ? 27.321 -5.010  -25.041 1.00 26.63  ? 278 ASN A O   1 
ATOM   2166 C CB  . ASN A 1 297 ? 24.336 -5.910  -25.168 1.00 30.73  ? 278 ASN A CB  1 
ATOM   2167 C CG  . ASN A 1 297 ? 23.713 -5.283  -23.947 1.00 30.63  ? 278 ASN A CG  1 
ATOM   2168 O OD1 . ASN A 1 297 ? 24.126 -4.224  -23.494 1.00 33.52  ? 278 ASN A OD1 1 
ATOM   2169 N ND2 . ASN A 1 297 ? 22.751 -5.992  -23.383 1.00 29.94  ? 278 ASN A ND2 1 
ATOM   2170 N N   . PRO A 1 298 ? 26.392 -2.981  -25.215 1.00 27.00  ? 279 PRO A N   1 
ATOM   2171 C CA  . PRO A 1 298 ? 27.535 -2.322  -24.591 1.00 26.49  ? 279 PRO A CA  1 
ATOM   2172 C C   . PRO A 1 298 ? 27.774 -2.740  -23.131 1.00 23.40  ? 279 PRO A C   1 
ATOM   2173 O O   . PRO A 1 298 ? 28.898 -2.693  -22.699 1.00 21.78  ? 279 PRO A O   1 
ATOM   2174 C CB  . PRO A 1 298 ? 27.231 -0.818  -24.683 1.00 28.03  ? 279 PRO A CB  1 
ATOM   2175 C CG  . PRO A 1 298 ? 25.760 -0.721  -24.971 1.00 29.43  ? 279 PRO A CG  1 
ATOM   2176 C CD  . PRO A 1 298 ? 25.355 -2.027  -25.640 1.00 30.39  ? 279 PRO A CD  1 
ATOM   2177 N N   . LEU A 1 299 ? 26.747 -3.205  -22.417 1.00 24.69  ? 280 LEU A N   1 
ATOM   2178 C CA  . LEU A 1 299 ? 26.967 -3.731  -21.043 1.00 25.56  ? 280 LEU A CA  1 
ATOM   2179 C C   . LEU A 1 299 ? 27.733 -5.064  -21.141 1.00 26.54  ? 280 LEU A C   1 
ATOM   2180 O O   . LEU A 1 299 ? 28.655 -5.267  -20.348 1.00 28.15  ? 280 LEU A O   1 
ATOM   2181 C CB  . LEU A 1 299 ? 25.631 -3.886  -20.306 1.00 26.45  ? 280 LEU A CB  1 
ATOM   2182 C CG  . LEU A 1 299 ? 24.788 -2.610  -20.162 1.00 26.48  ? 280 LEU A CG  1 
ATOM   2183 C CD1 . LEU A 1 299 ? 23.484 -2.887  -19.428 1.00 26.53  ? 280 LEU A CD1 1 
ATOM   2184 C CD2 . LEU A 1 299 ? 25.569 -1.537  -19.461 1.00 26.04  ? 280 LEU A CD2 1 
ATOM   2185 N N   . ALA A 1 300 ? 27.418 -5.923  -22.107 1.00 23.74  ? 281 ALA A N   1 
ATOM   2186 C CA  . ALA A 1 300 ? 28.198 -7.149  -22.396 1.00 23.69  ? 281 ALA A CA  1 
ATOM   2187 C C   . ALA A 1 300 ? 29.654 -6.785  -22.677 1.00 24.59  ? 281 ALA A C   1 
ATOM   2188 O O   . ALA A 1 300 ? 30.552 -7.382  -22.102 1.00 26.47  ? 281 ALA A O   1 
ATOM   2189 C CB  . ALA A 1 300 ? 27.582 -7.895  -23.551 1.00 25.65  ? 281 ALA A CB  1 
ATOM   2190 N N   . VAL A 1 301 ? 29.903 -5.806  -23.524 1.00 25.23  ? 282 VAL A N   1 
ATOM   2191 C CA  . VAL A 1 301 ? 31.295 -5.438  -23.868 1.00 25.17  ? 282 VAL A CA  1 
ATOM   2192 C C   . VAL A 1 301 ? 31.974 -4.943  -22.592 1.00 26.95  ? 282 VAL A C   1 
ATOM   2193 O O   . VAL A 1 301 ? 33.166 -5.239  -22.382 1.00 25.54  ? 282 VAL A O   1 
ATOM   2194 C CB  . VAL A 1 301 ? 31.354 -4.384  -24.989 1.00 25.24  ? 282 VAL A CB  1 
ATOM   2195 C CG1 . VAL A 1 301 ? 32.783 -3.954  -25.253 1.00 25.69  ? 282 VAL A CG1 1 
ATOM   2196 C CG2 . VAL A 1 301 ? 30.698 -4.900  -26.260 1.00 24.21  ? 282 VAL A CG2 1 
ATOM   2197 N N   . ASP A 1 302 ? 31.272 -4.158  -21.791 1.00 27.73  ? 283 ASP A N   1 
ATOM   2198 C CA  . ASP A 1 302 ? 31.850 -3.596  -20.546 1.00 27.54  ? 283 ASP A CA  1 
ATOM   2199 C C   . ASP A 1 302 ? 32.287 -4.760  -19.637 1.00 27.50  ? 283 ASP A C   1 
ATOM   2200 O O   . ASP A 1 302 ? 33.412 -4.765  -19.076 1.00 27.40  ? 283 ASP A O   1 
ATOM   2201 C CB  . ASP A 1 302 ? 30.812 -2.697  -19.876 1.00 31.67  ? 283 ASP A CB  1 
ATOM   2202 C CG  . ASP A 1 302 ? 31.389 -2.055  -18.638 1.00 33.18  ? 283 ASP A CG  1 
ATOM   2203 O OD1 . ASP A 1 302 ? 32.071 -1.025  -18.797 1.00 40.16  ? 283 ASP A OD1 1 
ATOM   2204 O OD2 . ASP A 1 302 ? 31.215 -2.642  -17.546 1.00 37.11  ? 283 ASP A OD2 1 
ATOM   2205 N N   . LEU A 1 303 ? 31.424 -5.748  -19.484 1.00 24.79  ? 284 LEU A N   1 
ATOM   2206 C CA  . LEU A 1 303 ? 31.728 -6.932  -18.642 1.00 25.26  ? 284 LEU A CA  1 
ATOM   2207 C C   . LEU A 1 303 ? 32.925 -7.689  -19.243 1.00 26.62  ? 284 LEU A C   1 
ATOM   2208 O O   . LEU A 1 303 ? 33.908 -8.005  -18.479 1.00 24.46  ? 284 LEU A O   1 
ATOM   2209 C CB  . LEU A 1 303 ? 30.458 -7.771  -18.541 1.00 24.83  ? 284 LEU A CB  1 
ATOM   2210 C CG  . LEU A 1 303 ? 30.572 -9.046  -17.714 1.00 26.14  ? 284 LEU A CG  1 
ATOM   2211 C CD1 . LEU A 1 303 ? 31.037 -8.760  -16.299 1.00 26.35  ? 284 LEU A CD1 1 
ATOM   2212 C CD2 . LEU A 1 303 ? 29.218 -9.727  -17.704 1.00 26.75  ? 284 LEU A CD2 1 
ATOM   2213 N N   . LEU A 1 304 ? 32.932 -7.893  -20.557 1.00 26.81  ? 285 LEU A N   1 
ATOM   2214 C CA  . LEU A 1 304 ? 34.094 -8.517  -21.237 1.00 29.22  ? 285 LEU A CA  1 
ATOM   2215 C C   . LEU A 1 304 ? 35.389 -7.793  -20.886 1.00 29.51  ? 285 LEU A C   1 
ATOM   2216 O O   . LEU A 1 304 ? 36.367 -8.500  -20.588 1.00 33.44  ? 285 LEU A O   1 
ATOM   2217 C CB  . LEU A 1 304 ? 33.905 -8.503  -22.751 1.00 33.25  ? 285 LEU A CB  1 
ATOM   2218 C CG  . LEU A 1 304 ? 33.217 -9.721  -23.343 1.00 38.24  ? 285 LEU A CG  1 
ATOM   2219 C CD1 . LEU A 1 304 ? 33.035 -9.514  -24.837 1.00 42.45  ? 285 LEU A CD1 1 
ATOM   2220 C CD2 . LEU A 1 304 ? 34.037 -10.981 -23.085 1.00 38.09  ? 285 LEU A CD2 1 
ATOM   2221 N N   . GLU A 1 305 ? 35.422 -6.458  -20.984 1.00 31.26  ? 286 GLU A N   1 
ATOM   2222 C CA  . GLU A 1 305 ? 36.594 -5.627  -20.587 1.00 33.84  ? 286 GLU A CA  1 
ATOM   2223 C C   . GLU A 1 305 ? 37.049 -6.039  -19.174 1.00 30.93  ? 286 GLU A C   1 
ATOM   2224 O O   . GLU A 1 305 ? 38.217 -6.072  -18.915 1.00 32.92  ? 286 GLU A O   1 
ATOM   2225 C CB  . GLU A 1 305 ? 36.239 -4.142  -20.486 1.00 40.46  ? 286 GLU A CB  1 
ATOM   2226 C CG  . GLU A 1 305 ? 36.078 -3.393  -21.801 1.00 47.46  ? 286 GLU A CG  1 
ATOM   2227 C CD  . GLU A 1 305 ? 37.365 -2.770  -22.302 1.00 48.93  ? 286 GLU A CD  1 
ATOM   2228 O OE1 . GLU A 1 305 ? 38.423 -3.096  -21.709 1.00 48.64  ? 286 GLU A OE1 1 
ATOM   2229 O OE2 . GLU A 1 305 ? 37.325 -1.995  -23.301 1.00 49.40  ? 286 GLU A OE2 1 
ATOM   2230 N N   . LYS A 1 306 ? 36.125 -6.246  -18.248 1.00 30.77  ? 287 LYS A N   1 
ATOM   2231 C CA  . LYS A 1 306 ? 36.434 -6.475  -16.814 1.00 31.12  ? 287 LYS A CA  1 
ATOM   2232 C C   . LYS A 1 306 ? 36.912 -7.910  -16.585 1.00 30.17  ? 287 LYS A C   1 
ATOM   2233 O O   . LYS A 1 306 ? 37.635 -8.116  -15.611 1.00 28.26  ? 287 LYS A O   1 
ATOM   2234 C CB  . LYS A 1 306 ? 35.217 -6.101  -15.977 1.00 34.54  ? 287 LYS A CB  1 
ATOM   2235 C CG  . LYS A 1 306 ? 35.036 -4.589  -15.904 1.00 33.50  ? 287 LYS A CG  1 
ATOM   2236 C CD  . LYS A 1 306 ? 33.780 -4.129  -15.248 1.00 39.70  ? 287 LYS A CD  1 
ATOM   2237 C CE  . LYS A 1 306 ? 33.724 -2.614  -15.152 1.00 46.71  ? 287 LYS A CE  1 
ATOM   2238 N NZ  . LYS A 1 306 ? 34.041 -1.961  -16.448 1.00 51.04  ? 287 LYS A NZ  1 
ATOM   2239 N N   . MET A 1 307 ? 36.604 -8.830  -17.501 1.00 28.32  ? 288 MET A N   1 
ATOM   2240 C CA  . MET A 1 307 ? 36.948 -10.267 -17.372 1.00 30.72  ? 288 MET A CA  1 
ATOM   2241 C C   . MET A 1 307 ? 38.310 -10.533 -18.015 1.00 29.12  ? 288 MET A C   1 
ATOM   2242 O O   . MET A 1 307 ? 39.052 -11.375 -17.487 1.00 25.64  ? 288 MET A O   1 
ATOM   2243 C CB  . MET A 1 307 ? 35.897 -11.159 -18.033 1.00 30.46  ? 288 MET A CB  1 
ATOM   2244 C CG  . MET A 1 307 ? 34.626 -11.300 -17.216 1.00 34.11  ? 288 MET A CG  1 
ATOM   2245 S SD  . MET A 1 307 ? 33.391 -12.209 -18.139 1.00 36.51  ? 288 MET A SD  1 
ATOM   2246 C CE  . MET A 1 307 ? 32.057 -12.287 -16.959 1.00 43.55  ? 288 MET A CE  1 
ATOM   2247 N N   . LEU A 1 308 ? 38.603 -9.868  -19.122 1.00 27.04  ? 289 LEU A N   1 
ATOM   2248 C CA  . LEU A 1 308 ? 39.797 -10.161 -19.947 1.00 27.28  ? 289 LEU A CA  1 
ATOM   2249 C C   . LEU A 1 308 ? 40.890 -9.133  -19.645 1.00 30.34  ? 289 LEU A C   1 
ATOM   2250 O O   . LEU A 1 308 ? 41.470 -8.568  -20.567 1.00 33.70  ? 289 LEU A O   1 
ATOM   2251 C CB  . LEU A 1 308 ? 39.390 -10.128 -21.421 1.00 26.82  ? 289 LEU A CB  1 
ATOM   2252 C CG  . LEU A 1 308 ? 38.439 -11.239 -21.855 1.00 26.91  ? 289 LEU A CG  1 
ATOM   2253 C CD1 . LEU A 1 308 ? 38.104 -11.099 -23.326 1.00 28.28  ? 289 LEU A CD1 1 
ATOM   2254 C CD2 . LEU A 1 308 ? 39.041 -12.611 -21.583 1.00 27.62  ? 289 LEU A CD2 1 
ATOM   2255 N N   . VAL A 1 309 ? 41.201 -8.961  -18.378 1.00 31.81  ? 290 VAL A N   1 
ATOM   2256 C CA  . VAL A 1 309 ? 42.309 -8.091  -17.917 1.00 34.07  ? 290 VAL A CA  1 
ATOM   2257 C C   . VAL A 1 309 ? 43.528 -8.992  -17.777 1.00 34.62  ? 290 VAL A C   1 
ATOM   2258 O O   . VAL A 1 309 ? 43.374 -10.095 -17.235 1.00 34.72  ? 290 VAL A O   1 
ATOM   2259 C CB  . VAL A 1 309 ? 41.935 -7.438  -16.579 1.00 37.39  ? 290 VAL A CB  1 
ATOM   2260 C CG1 . VAL A 1 309 ? 43.025 -6.504  -16.093 1.00 40.39  ? 290 VAL A CG1 1 
ATOM   2261 C CG2 . VAL A 1 309 ? 40.609 -6.718  -16.680 1.00 36.64  ? 290 VAL A CG2 1 
ATOM   2262 N N   . LEU A 1 310 ? 44.682 -8.559  -18.263 1.00 35.70  ? 291 LEU A N   1 
ATOM   2263 C CA  . LEU A 1 310 ? 45.870 -9.441  -18.309 1.00 36.30  ? 291 LEU A CA  1 
ATOM   2264 C C   . LEU A 1 310 ? 46.270 -9.762  -16.879 1.00 34.12  ? 291 LEU A C   1 
ATOM   2265 O O   . LEU A 1 310 ? 46.599 -10.914 -16.603 1.00 39.28  ? 291 LEU A O   1 
ATOM   2266 C CB  . LEU A 1 310 ? 47.002 -8.748  -19.063 1.00 39.14  ? 291 LEU A CB  1 
ATOM   2267 C CG  . LEU A 1 310 ? 48.239 -9.622  -19.278 1.00 43.01  ? 291 LEU A CG  1 
ATOM   2268 C CD1 . LEU A 1 310 ? 47.909 -10.888 -20.062 1.00 37.76  ? 291 LEU A CD1 1 
ATOM   2269 C CD2 . LEU A 1 310 ? 49.331 -8.827  -19.975 1.00 42.32  ? 291 LEU A CD2 1 
ATOM   2270 N N   . ASP A 1 311 ? 46.226 -8.765  -15.995 1.00 36.49  ? 292 ASP A N   1 
ATOM   2271 C CA  . ASP A 1 311 ? 46.642 -8.944  -14.578 1.00 38.96  ? 292 ASP A CA  1 
ATOM   2272 C C   . ASP A 1 311 ? 45.502 -9.663  -13.852 1.00 36.74  ? 292 ASP A C   1 
ATOM   2273 O O   . ASP A 1 311 ? 44.460 -9.030  -13.615 1.00 36.86  ? 292 ASP A O   1 
ATOM   2274 C CB  . ASP A 1 311 ? 47.011 -7.620  -13.905 1.00 39.20  ? 292 ASP A CB  1 
ATOM   2275 C CG  . ASP A 1 311 ? 47.671 -7.777  -12.537 1.00 42.33  ? 292 ASP A CG  1 
ATOM   2276 O OD1 . ASP A 1 311 ? 47.490 -8.842  -11.893 1.00 40.33  ? 292 ASP A OD1 1 
ATOM   2277 O OD2 . ASP A 1 311 ? 48.381 -6.836  -12.125 1.00 49.77  ? 292 ASP A OD2 1 
ATOM   2278 N N   . SER A 1 312 ? 45.713 -10.931 -13.516 1.00 36.07  ? 293 SER A N   1 
ATOM   2279 C CA  . SER A 1 312 ? 44.705 -11.803 -12.861 1.00 37.36  ? 293 SER A CA  1 
ATOM   2280 C C   . SER A 1 312 ? 44.176 -11.142 -11.579 1.00 35.47  ? 293 SER A C   1 
ATOM   2281 O O   . SER A 1 312 ? 43.022 -11.350 -11.251 1.00 32.94  ? 293 SER A O   1 
ATOM   2282 C CB  . SER A 1 312 ? 45.277 -13.179 -12.587 1.00 34.99  ? 293 SER A CB  1 
ATOM   2283 O OG  . SER A 1 312 ? 46.060 -13.194 -11.407 1.00 36.59  ? 293 SER A OG  1 
ATOM   2284 N N   . ASP A 1 313 ? 44.987 -10.350 -10.890 1.00 35.39  ? 294 ASP A N   1 
ATOM   2285 C CA  . ASP A 1 313 ? 44.548 -9.665  -9.647  1.00 37.44  ? 294 ASP A CA  1 
ATOM   2286 C C   . ASP A 1 313 ? 43.462 -8.614  -9.930  1.00 35.45  ? 294 ASP A C   1 
ATOM   2287 O O   . ASP A 1 313 ? 42.764 -8.229  -8.985  1.00 34.48  ? 294 ASP A O   1 
ATOM   2288 C CB  . ASP A 1 313 ? 45.738 -9.015  -8.945  1.00 42.13  ? 294 ASP A CB  1 
ATOM   2289 C CG  . ASP A 1 313 ? 46.600 -10.006 -8.178  1.00 47.83  ? 294 ASP A CG  1 
ATOM   2290 O OD1 . ASP A 1 313 ? 46.080 -11.069 -7.795  1.00 45.37  ? 294 ASP A OD1 1 
ATOM   2291 O OD2 . ASP A 1 313 ? 47.785 -9.692  -7.956  1.00 56.04  ? 294 ASP A OD2 1 
ATOM   2292 N N   . LYS A 1 314 ? 43.331 -8.144  -11.161 1.00 34.75  ? 295 LYS A N   1 
ATOM   2293 C CA  . LYS A 1 314 ? 42.463 -6.980  -11.497 1.00 38.06  ? 295 LYS A CA  1 
ATOM   2294 C C   . LYS A 1 314 ? 41.214 -7.467  -12.248 1.00 34.26  ? 295 LYS A C   1 
ATOM   2295 O O   . LYS A 1 314 ? 40.323 -6.671  -12.517 1.00 34.11  ? 295 LYS A O   1 
ATOM   2296 C CB  . LYS A 1 314 ? 43.309 -5.955  -12.264 1.00 42.04  ? 295 LYS A CB  1 
ATOM   2297 C CG  . LYS A 1 314 ? 44.431 -5.361  -11.414 1.00 48.33  ? 295 LYS A CG  1 
ATOM   2298 C CD  . LYS A 1 314 ? 45.341 -4.410  -12.133 1.00 60.93  ? 295 LYS A CD  1 
ATOM   2299 C CE  . LYS A 1 314 ? 46.426 -3.835  -11.240 1.00 74.31  ? 295 LYS A CE  1 
ATOM   2300 N NZ  . LYS A 1 314 ? 45.893 -3.369  -9.933  1.00 76.10  ? 295 LYS A NZ  1 
ATOM   2301 N N   . ARG A 1 315 ? 41.128 -8.749  -12.586 1.00 31.71  ? 296 ARG A N   1 
ATOM   2302 C CA  . ARG A 1 315 ? 39.889 -9.258  -13.220 1.00 29.50  ? 296 ARG A CA  1 
ATOM   2303 C C   . ARG A 1 315 ? 38.732 -9.201  -12.223 1.00 27.74  ? 296 ARG A C   1 
ATOM   2304 O O   . ARG A 1 315 ? 38.933 -9.522  -11.060 1.00 32.26  ? 296 ARG A O   1 
ATOM   2305 C CB  . ARG A 1 315 ? 40.061 -10.702 -13.662 1.00 29.59  ? 296 ARG A CB  1 
ATOM   2306 C CG  . ARG A 1 315 ? 40.986 -10.859 -14.845 1.00 31.59  ? 296 ARG A CG  1 
ATOM   2307 C CD  . ARG A 1 315 ? 41.316 -12.309 -15.057 1.00 30.29  ? 296 ARG A CD  1 
ATOM   2308 N NE  . ARG A 1 315 ? 42.526 -12.363 -15.856 1.00 32.24  ? 296 ARG A NE  1 
ATOM   2309 C CZ  . ARG A 1 315 ? 43.369 -13.379 -15.892 1.00 33.25  ? 296 ARG A CZ  1 
ATOM   2310 N NH1 . ARG A 1 315 ? 43.142 -14.462 -15.164 1.00 33.46  ? 296 ARG A NH1 1 
ATOM   2311 N NH2 . ARG A 1 315 ? 44.462 -13.286 -16.631 1.00 33.15  ? 296 ARG A NH2 1 
ATOM   2312 N N   . ILE A 1 316 ? 37.537 -8.892  -12.691 1.00 24.47  ? 297 ILE A N   1 
ATOM   2313 C CA  . ILE A 1 316 ? 36.299 -9.038  -11.876 1.00 25.48  ? 297 ILE A CA  1 
ATOM   2314 C C   . ILE A 1 316 ? 36.203 -10.495 -11.351 1.00 25.51  ? 297 ILE A C   1 
ATOM   2315 O O   . ILE A 1 316 ? 36.611 -11.436 -12.046 1.00 24.45  ? 297 ILE A O   1 
ATOM   2316 C CB  . ILE A 1 316 ? 35.124 -8.606  -12.762 1.00 25.65  ? 297 ILE A CB  1 
ATOM   2317 C CG1 . ILE A 1 316 ? 33.858 -8.347  -11.973 1.00 25.48  ? 297 ILE A CG1 1 
ATOM   2318 C CG2 . ILE A 1 316 ? 34.903 -9.593  -13.884 1.00 26.23  ? 297 ILE A CG2 1 
ATOM   2319 C CD1 . ILE A 1 316 ? 32.840 -7.575  -12.752 1.00 28.16  ? 297 ILE A CD1 1 
ATOM   2320 N N   . THR A 1 317 ? 35.754 -10.671 -10.117 1.00 23.56  ? 298 THR A N   1 
ATOM   2321 C CA  . THR A 1 317 ? 35.473 -11.989 -9.503  1.00 22.80  ? 298 THR A CA  1 
ATOM   2322 C C   . THR A 1 317 ? 34.067 -12.429 -9.927  1.00 23.55  ? 298 THR A C   1 
ATOM   2323 O O   . THR A 1 317 ? 33.260 -11.565 -10.382 1.00 22.26  ? 298 THR A O   1 
ATOM   2324 C CB  . THR A 1 317 ? 35.538 -11.899 -7.972  1.00 24.31  ? 298 THR A CB  1 
ATOM   2325 O OG1 . THR A 1 317 ? 34.396 -11.119 -7.594  1.00 23.49  ? 298 THR A OG1 1 
ATOM   2326 C CG2 . THR A 1 317 ? 36.833 -11.296 -7.458  1.00 23.71  ? 298 THR A CG2 1 
ATOM   2327 N N   . ALA A 1 318 ? 33.748 -13.710 -9.768  1.00 23.59  ? 299 ALA A N   1 
ATOM   2328 C CA  . ALA A 1 318 ? 32.403 -14.235 -10.078 1.00 22.45  ? 299 ALA A CA  1 
ATOM   2329 C C   . ALA A 1 318 ? 31.341 -13.418 -9.345  1.00 24.54  ? 299 ALA A C   1 
ATOM   2330 O O   . ALA A 1 318 ? 30.355 -13.028 -9.980  1.00 23.25  ? 299 ALA A O   1 
ATOM   2331 C CB  . ALA A 1 318 ? 32.320 -15.699 -9.749  1.00 23.17  ? 299 ALA A CB  1 
ATOM   2332 N N   . ALA A 1 319 ? 31.492 -13.225 -8.036  1.00 26.11  ? 300 ALA A N   1 
ATOM   2333 C CA  . ALA A 1 319 ? 30.493 -12.513 -7.196  1.00 27.02  ? 300 ALA A CA  1 
ATOM   2334 C C   . ALA A 1 319 ? 30.241 -11.082 -7.714  1.00 26.54  ? 300 ALA A C   1 
ATOM   2335 O O   . ALA A 1 319 ? 29.075 -10.694 -7.779  1.00 29.96  ? 300 ALA A O   1 
ATOM   2336 C CB  . ALA A 1 319 ? 30.939 -12.474 -5.750  1.00 26.76  ? 300 ALA A CB  1 
ATOM   2337 N N   . GLN A 1 320 ? 31.292 -10.299 -7.949  1.00 26.05  ? 301 GLN A N   1 
ATOM   2338 C CA  . GLN A 1 320 ? 31.209 -8.933  -8.534  1.00 26.89  ? 301 GLN A CA  1 
ATOM   2339 C C   . GLN A 1 320 ? 30.478 -9.023  -9.881  1.00 26.97  ? 301 GLN A C   1 
ATOM   2340 O O   . GLN A 1 320 ? 29.532 -8.263  -10.108 1.00 24.63  ? 301 GLN A O   1 
ATOM   2341 C CB  . GLN A 1 320 ? 32.616 -8.362  -8.732  1.00 31.73  ? 301 GLN A CB  1 
ATOM   2342 C CG  . GLN A 1 320 ? 33.358 -8.030  -7.445  1.00 33.05  ? 301 GLN A CG  1 
ATOM   2343 C CD  . GLN A 1 320 ? 34.863 -7.876  -7.584  1.00 38.22  ? 301 GLN A CD  1 
ATOM   2344 O OE1 . GLN A 1 320 ? 35.485 -8.170  -8.604  1.00 29.21  ? 301 GLN A OE1 1 
ATOM   2345 N NE2 . GLN A 1 320 ? 35.489 -7.431  -6.506  1.00 43.04  ? 301 GLN A NE2 1 
ATOM   2346 N N   . ALA A 1 321 ? 30.855 -9.981  -10.726 1.00 25.24  ? 302 ALA A N   1 
ATOM   2347 C CA  . ALA A 1 321 ? 30.318 -10.097 -12.099 1.00 25.71  ? 302 ALA A CA  1 
ATOM   2348 C C   . ALA A 1 321 ? 28.804 -10.280 -12.041 1.00 23.83  ? 302 ALA A C   1 
ATOM   2349 O O   . ALA A 1 321 ? 28.112 -9.692  -12.889 1.00 21.05  ? 302 ALA A O   1 
ATOM   2350 C CB  . ALA A 1 321 ? 30.999 -11.209 -12.852 1.00 26.55  ? 302 ALA A CB  1 
ATOM   2351 N N   . LEU A 1 322 ? 28.303 -11.019 -11.048 1.00 24.08  ? 303 LEU A N   1 
ATOM   2352 C CA  . LEU A 1 322 ? 26.838 -11.288 -10.913 1.00 25.79  ? 303 LEU A CA  1 
ATOM   2353 C C   . LEU A 1 322 ? 26.073 -9.983  -10.679 1.00 24.91  ? 303 LEU A C   1 
ATOM   2354 O O   . LEU A 1 322 ? 24.900 -9.933  -11.045 1.00 24.46  ? 303 LEU A O   1 
ATOM   2355 C CB  . LEU A 1 322 ? 26.593 -12.280 -9.777  1.00 25.79  ? 303 LEU A CB  1 
ATOM   2356 C CG  . LEU A 1 322 ? 26.977 -13.720 -10.084 1.00 27.11  ? 303 LEU A CG  1 
ATOM   2357 C CD1 . LEU A 1 322 ? 26.985 -14.550 -8.817  1.00 28.91  ? 303 LEU A CD1 1 
ATOM   2358 C CD2 . LEU A 1 322 ? 26.044 -14.356 -11.089 1.00 28.90  ? 303 LEU A CD2 1 
ATOM   2359 N N   . ALA A 1 323 ? 26.719 -8.977  -10.079 1.00 24.84  ? 304 ALA A N   1 
ATOM   2360 C CA  . ALA A 1 323 ? 26.101 -7.660  -9.796  1.00 28.46  ? 304 ALA A CA  1 
ATOM   2361 C C   . ALA A 1 323 ? 26.219 -6.716  -11.000 1.00 27.94  ? 304 ALA A C   1 
ATOM   2362 O O   . ALA A 1 323 ? 25.750 -5.596  -10.874 1.00 28.57  ? 304 ALA A O   1 
ATOM   2363 C CB  . ALA A 1 323 ? 26.745 -7.022  -8.585  1.00 28.27  ? 304 ALA A CB  1 
ATOM   2364 N N   . HIS A 1 324 ? 26.893 -7.098  -12.083 1.00 26.96  ? 305 HIS A N   1 
ATOM   2365 C CA  . HIS A 1 324 ? 27.035 -6.204  -13.264 1.00 27.26  ? 305 HIS A CA  1 
ATOM   2366 C C   . HIS A 1 324 ? 25.651 -5.987  -13.897 1.00 27.00  ? 305 HIS A C   1 
ATOM   2367 O O   . HIS A 1 324 ? 24.831 -6.946  -13.881 1.00 26.10  ? 305 HIS A O   1 
ATOM   2368 C CB  . HIS A 1 324 ? 28.082 -6.781  -14.202 1.00 26.34  ? 305 HIS A CB  1 
ATOM   2369 C CG  . HIS A 1 324 ? 28.482 -5.885  -15.315 1.00 24.82  ? 305 HIS A CG  1 
ATOM   2370 N ND1 . HIS A 1 324 ? 27.630 -5.601  -16.351 1.00 22.48  ? 305 HIS A ND1 1 
ATOM   2371 C CD2 . HIS A 1 324 ? 29.656 -5.256  -15.576 1.00 24.94  ? 305 HIS A CD2 1 
ATOM   2372 C CE1 . HIS A 1 324 ? 28.257 -4.809  -17.207 1.00 24.51  ? 305 HIS A CE1 1 
ATOM   2373 N NE2 . HIS A 1 324 ? 29.509 -4.566  -16.754 1.00 22.42  ? 305 HIS A NE2 1 
ATOM   2374 N N   . ALA A 1 325 ? 25.363 -4.776  -14.399 1.00 22.31  ? 306 ALA A N   1 
ATOM   2375 C CA  . ALA A 1 325 ? 24.050 -4.417  -14.984 1.00 21.77  ? 306 ALA A CA  1 
ATOM   2376 C C   . ALA A 1 325 ? 23.702 -5.326  -16.163 1.00 22.90  ? 306 ALA A C   1 
ATOM   2377 O O   . ALA A 1 325 ? 22.486 -5.530  -16.426 1.00 23.93  ? 306 ALA A O   1 
ATOM   2378 C CB  . ALA A 1 325 ? 24.066 -2.970  -15.403 1.00 24.59  ? 306 ALA A CB  1 
ATOM   2379 N N   . TYR A 1 326 ? 24.695 -5.902  -16.856 1.00 23.26  ? 307 TYR A N   1 
ATOM   2380 C CA  . TYR A 1 326 ? 24.409 -6.867  -17.944 1.00 25.84  ? 307 TYR A CA  1 
ATOM   2381 C C   . TYR A 1 326 ? 23.387 -7.909  -17.447 1.00 26.18  ? 307 TYR A C   1 
ATOM   2382 O O   . TYR A 1 326 ? 22.505 -8.250  -18.210 1.00 27.94  ? 307 TYR A O   1 
ATOM   2383 C CB  . TYR A 1 326 ? 25.701 -7.488  -18.495 1.00 28.97  ? 307 TYR A CB  1 
ATOM   2384 C CG  . TYR A 1 326 ? 25.486 -8.411  -19.672 1.00 31.41  ? 307 TYR A CG  1 
ATOM   2385 C CD1 . TYR A 1 326 ? 24.779 -7.985  -20.788 1.00 30.09  ? 307 TYR A CD1 1 
ATOM   2386 C CD2 . TYR A 1 326 ? 25.950 -9.726  -19.663 1.00 32.28  ? 307 TYR A CD2 1 
ATOM   2387 C CE1 . TYR A 1 326 ? 24.567 -8.819  -21.874 1.00 29.23  ? 307 TYR A CE1 1 
ATOM   2388 C CE2 . TYR A 1 326 ? 25.737 -10.570 -20.746 1.00 31.02  ? 307 TYR A CE2 1 
ATOM   2389 C CZ  . TYR A 1 326 ? 25.055 -10.110 -21.859 1.00 30.90  ? 307 TYR A CZ  1 
ATOM   2390 O OH  . TYR A 1 326 ? 24.807 -10.913 -22.931 1.00 34.37  ? 307 TYR A OH  1 
ATOM   2391 N N   . PHE A 1 327 ? 23.473 -8.374  -16.196 1.00 25.65  ? 308 PHE A N   1 
ATOM   2392 C CA  . PHE A 1 327 ? 22.611 -9.464  -15.667 1.00 26.56  ? 308 PHE A CA  1 
ATOM   2393 C C   . PHE A 1 327 ? 21.434 -8.919  -14.863 1.00 28.02  ? 308 PHE A C   1 
ATOM   2394 O O   . PHE A 1 327 ? 20.858 -9.723  -14.111 1.00 29.26  ? 308 PHE A O   1 
ATOM   2395 C CB  . PHE A 1 327 ? 23.391 -10.418 -14.758 1.00 24.58  ? 308 PHE A CB  1 
ATOM   2396 C CG  . PHE A 1 327 ? 24.586 -11.019 -15.423 1.00 22.48  ? 308 PHE A CG  1 
ATOM   2397 C CD1 . PHE A 1 327 ? 24.436 -11.835 -16.534 1.00 23.70  ? 308 PHE A CD1 1 
ATOM   2398 C CD2 . PHE A 1 327 ? 25.857 -10.709 -14.997 1.00 21.60  ? 308 PHE A CD2 1 
ATOM   2399 C CE1 . PHE A 1 327 ? 25.551 -12.360 -17.174 1.00 21.68  ? 308 PHE A CE1 1 
ATOM   2400 C CE2 . PHE A 1 327 ? 26.967 -11.202 -15.672 1.00 21.54  ? 308 PHE A CE2 1 
ATOM   2401 C CZ  . PHE A 1 327 ? 26.812 -12.021 -16.755 1.00 20.15  ? 308 PHE A CZ  1 
ATOM   2402 N N   . ALA A 1 328 ? 21.040 -7.655  -15.047 1.00 29.02  ? 309 ALA A N   1 
ATOM   2403 C CA  . ALA A 1 328 ? 20.019 -7.010  -14.184 1.00 31.02  ? 309 ALA A CA  1 
ATOM   2404 C C   . ALA A 1 328 ? 18.765 -7.878  -14.138 1.00 30.44  ? 309 ALA A C   1 
ATOM   2405 O O   . ALA A 1 328 ? 18.143 -7.984  -13.080 1.00 34.22  ? 309 ALA A O   1 
ATOM   2406 C CB  . ALA A 1 328 ? 19.697 -5.626  -14.679 1.00 32.23  ? 309 ALA A CB  1 
ATOM   2407 N N   . GLN A 1 329 ? 18.400 -8.465  -15.261 1.00 30.16  ? 310 GLN A N   1 
ATOM   2408 C CA  . GLN A 1 329 ? 17.162 -9.267  -15.394 1.00 34.80  ? 310 GLN A CA  1 
ATOM   2409 C C   . GLN A 1 329 ? 17.241 -10.553 -14.536 1.00 32.51  ? 310 GLN A C   1 
ATOM   2410 O O   . GLN A 1 329 ? 16.193 -11.096 -14.164 1.00 34.30  ? 310 GLN A O   1 
ATOM   2411 C CB  . GLN A 1 329 ? 17.002 -9.513  -16.898 1.00 45.26  ? 310 GLN A CB  1 
ATOM   2412 C CG  . GLN A 1 329 ? 15.726 -10.220 -17.328 1.00 57.51  ? 310 GLN A CG  1 
ATOM   2413 C CD  . GLN A 1 329 ? 15.829 -10.712 -18.757 1.00 68.54  ? 310 GLN A CD  1 
ATOM   2414 O OE1 . GLN A 1 329 ? 16.818 -10.476 -19.460 1.00 76.71  ? 310 GLN A OE1 1 
ATOM   2415 N NE2 . GLN A 1 329 ? 14.804 -11.420 -19.207 1.00 74.10  ? 310 GLN A NE2 1 
ATOM   2416 N N   . TYR A 1 330 ? 18.428 -11.097 -14.269 1.00 26.69  ? 311 TYR A N   1 
ATOM   2417 C CA  . TYR A 1 330 ? 18.569 -12.459 -13.680 1.00 26.42  ? 311 TYR A CA  1 
ATOM   2418 C C   . TYR A 1 330 ? 19.103 -12.398 -12.243 1.00 26.57  ? 311 TYR A C   1 
ATOM   2419 O O   . TYR A 1 330 ? 18.888 -13.328 -11.460 1.00 28.17  ? 311 TYR A O   1 
ATOM   2420 C CB  . TYR A 1 330 ? 19.485 -13.314 -14.559 1.00 24.96  ? 311 TYR A CB  1 
ATOM   2421 C CG  . TYR A 1 330 ? 18.841 -13.682 -15.860 1.00 23.97  ? 311 TYR A CG  1 
ATOM   2422 C CD1 . TYR A 1 330 ? 17.811 -14.601 -15.888 1.00 26.62  ? 311 TYR A CD1 1 
ATOM   2423 C CD2 . TYR A 1 330 ? 19.226 -13.094 -17.040 1.00 25.21  ? 311 TYR A CD2 1 
ATOM   2424 C CE1 . TYR A 1 330 ? 17.183 -14.946 -17.070 1.00 28.76  ? 311 TYR A CE1 1 
ATOM   2425 C CE2 . TYR A 1 330 ? 18.616 -13.432 -18.231 1.00 28.46  ? 311 TYR A CE2 1 
ATOM   2426 C CZ  . TYR A 1 330 ? 17.584 -14.347 -18.250 1.00 29.10  ? 311 TYR A CZ  1 
ATOM   2427 O OH  . TYR A 1 330 ? 16.954 -14.651 -19.422 1.00 34.25  ? 311 TYR A OH  1 
ATOM   2428 N N   . HIS A 1 331 ? 19.815 -11.332 -11.915 1.00 25.95  ? 312 HIS A N   1 
ATOM   2429 C CA  . HIS A 1 331 ? 20.558 -11.196 -10.643 1.00 27.06  ? 312 HIS A CA  1 
ATOM   2430 C C   . HIS A 1 331 ? 19.606 -11.234 -9.448  1.00 31.00  ? 312 HIS A C   1 
ATOM   2431 O O   . HIS A 1 331 ? 18.667 -10.429 -9.391  1.00 27.13  ? 312 HIS A O   1 
ATOM   2432 C CB  . HIS A 1 331 ? 21.344 -9.910  -10.687 1.00 25.97  ? 312 HIS A CB  1 
ATOM   2433 C CG  . HIS A 1 331 ? 22.040 -9.591  -9.419  1.00 30.58  ? 312 HIS A CG  1 
ATOM   2434 N ND1 . HIS A 1 331 ? 22.746 -10.560 -8.697  1.00 25.96  ? 312 HIS A ND1 1 
ATOM   2435 C CD2 . HIS A 1 331 ? 22.183 -8.401  -8.780  1.00 25.79  ? 312 HIS A CD2 1 
ATOM   2436 C CE1 . HIS A 1 331 ? 23.270 -9.966  -7.652  1.00 28.70  ? 312 HIS A CE1 1 
ATOM   2437 N NE2 . HIS A 1 331 ? 22.964 -8.630  -7.691  1.00 26.45  ? 312 HIS A NE2 1 
ATOM   2438 N N   . ASP A 1 332 ? 19.885 -12.116 -8.488  1.00 32.68  ? 313 ASP A N   1 
ATOM   2439 C CA  . ASP A 1 332 ? 19.137 -12.158 -7.214  1.00 29.60  ? 313 ASP A CA  1 
ATOM   2440 C C   . ASP A 1 332 ? 20.129 -12.478 -6.117  1.00 31.82  ? 313 ASP A C   1 
ATOM   2441 O O   . ASP A 1 332 ? 20.570 -13.620 -5.978  1.00 31.12  ? 313 ASP A O   1 
ATOM   2442 C CB  . ASP A 1 332 ? 17.990 -13.152 -7.284  1.00 30.99  ? 313 ASP A CB  1 
ATOM   2443 C CG  . ASP A 1 332 ? 17.163 -13.124 -6.013  1.00 32.20  ? 313 ASP A CG  1 
ATOM   2444 O OD1 . ASP A 1 332 ? 17.523 -12.389 -5.061  1.00 31.34  ? 313 ASP A OD1 1 
ATOM   2445 O OD2 . ASP A 1 332 ? 16.211 -13.852 -5.983  1.00 37.69  ? 313 ASP A OD2 1 
ATOM   2446 N N   . PRO A 1 333 ? 20.521 -11.469 -5.322  1.00 34.76  ? 314 PRO A N   1 
ATOM   2447 C CA  . PRO A 1 333 ? 21.553 -11.661 -4.309  1.00 39.64  ? 314 PRO A CA  1 
ATOM   2448 C C   . PRO A 1 333 ? 21.140 -12.698 -3.249  1.00 36.88  ? 314 PRO A C   1 
ATOM   2449 O O   . PRO A 1 333 ? 22.013 -13.233 -2.605  1.00 39.05  ? 314 PRO A O   1 
ATOM   2450 C CB  . PRO A 1 333 ? 21.733 -10.281 -3.670  1.00 41.35  ? 314 PRO A CB  1 
ATOM   2451 C CG  . PRO A 1 333 ? 21.049 -9.309  -4.614  1.00 42.45  ? 314 PRO A CG  1 
ATOM   2452 C CD  . PRO A 1 333 ? 19.986 -10.104 -5.342  1.00 40.53  ? 314 PRO A CD  1 
ATOM   2453 N N   . ASP A 1 334 ? 19.842 -12.997 -3.126  1.00 32.71  ? 315 ASP A N   1 
ATOM   2454 C CA  . ASP A 1 334 ? 19.333 -13.979 -2.127  1.00 32.34  ? 315 ASP A CA  1 
ATOM   2455 C C   . ASP A 1 334 ? 19.283 -15.376 -2.729  1.00 32.54  ? 315 ASP A C   1 
ATOM   2456 O O   . ASP A 1 334 ? 18.916 -16.301 -1.972  1.00 31.14  ? 315 ASP A O   1 
ATOM   2457 C CB  . ASP A 1 334 ? 17.937 -13.617 -1.620  1.00 34.37  ? 315 ASP A CB  1 
ATOM   2458 C CG  . ASP A 1 334 ? 17.949 -12.309 -0.848  1.00 39.16  ? 315 ASP A CG  1 
ATOM   2459 O OD1 . ASP A 1 334 ? 18.974 -12.038 -0.165  1.00 41.81  ? 315 ASP A OD1 1 
ATOM   2460 O OD2 . ASP A 1 334 ? 16.971 -11.549 -0.983  1.00 43.72  ? 315 ASP A OD2 1 
ATOM   2461 N N   . ASP A 1 335 ? 19.570 -15.530 -4.029  1.00 28.04  ? 316 ASP A N   1 
ATOM   2462 C CA  . ASP A 1 335 ? 19.551 -16.881 -4.634  1.00 29.39  ? 316 ASP A CA  1 
ATOM   2463 C C   . ASP A 1 335 ? 20.847 -17.080 -5.432  1.00 28.30  ? 316 ASP A C   1 
ATOM   2464 O O   . ASP A 1 335 ? 20.794 -17.593 -6.554  1.00 29.84  ? 316 ASP A O   1 
ATOM   2465 C CB  . ASP A 1 335 ? 18.248 -17.055 -5.413  1.00 30.86  ? 316 ASP A CB  1 
ATOM   2466 C CG  . ASP A 1 335 ? 18.045 -18.450 -5.975  1.00 34.36  ? 316 ASP A CG  1 
ATOM   2467 O OD1 . ASP A 1 335 ? 18.503 -19.432 -5.322  1.00 32.53  ? 316 ASP A OD1 1 
ATOM   2468 O OD2 . ASP A 1 335 ? 17.473 -18.536 -7.086  1.00 35.99  ? 316 ASP A OD2 1 
ATOM   2469 N N   . GLU A 1 336 ? 21.976 -16.629 -4.892  1.00 28.65  ? 317 GLU A N   1 
ATOM   2470 C CA  . GLU A 1 336 ? 23.324 -16.850 -5.485  1.00 26.19  ? 317 GLU A CA  1 
ATOM   2471 C C   . GLU A 1 336 ? 24.216 -17.407 -4.386  1.00 24.36  ? 317 GLU A C   1 
ATOM   2472 O O   . GLU A 1 336 ? 25.121 -16.741 -3.868  1.00 24.87  ? 317 GLU A O   1 
ATOM   2473 C CB  . GLU A 1 336 ? 23.826 -15.554 -6.108  1.00 25.94  ? 317 GLU A CB  1 
ATOM   2474 C CG  . GLU A 1 336 ? 22.998 -15.186 -7.325  1.00 25.43  ? 317 GLU A CG  1 
ATOM   2475 C CD  . GLU A 1 336 ? 23.146 -13.763 -7.823  1.00 27.16  ? 317 GLU A CD  1 
ATOM   2476 O OE1 . GLU A 1 336 ? 23.920 -12.971 -7.205  1.00 27.32  ? 317 GLU A OE1 1 
ATOM   2477 O OE2 . GLU A 1 336 ? 22.461 -13.451 -8.824  1.00 27.18  ? 317 GLU A OE2 1 
ATOM   2478 N N   . PRO A 1 337 ? 23.931 -18.641 -3.949  1.00 25.52  ? 318 PRO A N   1 
ATOM   2479 C CA  . PRO A 1 337 ? 24.507 -19.151 -2.711  1.00 28.87  ? 318 PRO A CA  1 
ATOM   2480 C C   . PRO A 1 337 ? 25.991 -19.496 -2.839  1.00 30.45  ? 318 PRO A C   1 
ATOM   2481 O O   . PRO A 1 337 ? 26.469 -19.762 -3.967  1.00 31.00  ? 318 PRO A O   1 
ATOM   2482 C CB  . PRO A 1 337 ? 23.754 -20.450 -2.448  1.00 29.68  ? 318 PRO A CB  1 
ATOM   2483 C CG  . PRO A 1 337 ? 23.263 -20.874 -3.802  1.00 30.41  ? 318 PRO A CG  1 
ATOM   2484 C CD  . PRO A 1 337 ? 23.031 -19.598 -4.591  1.00 27.23  ? 318 PRO A CD  1 
ATOM   2485 N N   . VAL A 1 338 ? 26.662 -19.486 -1.691  1.00 29.83  ? 319 VAL A N   1 
ATOM   2486 C CA  . VAL A 1 338 ? 28.066 -19.942 -1.515  1.00 28.51  ? 319 VAL A CA  1 
ATOM   2487 C C   . VAL A 1 338 ? 28.064 -21.374 -0.969  1.00 27.83  ? 319 VAL A C   1 
ATOM   2488 O O   . VAL A 1 338 ? 26.984 -21.914 -0.642  1.00 27.41  ? 319 VAL A O   1 
ATOM   2489 C CB  . VAL A 1 338 ? 28.839 -18.986 -0.591  1.00 31.48  ? 319 VAL A CB  1 
ATOM   2490 C CG1 . VAL A 1 338 ? 29.008 -17.617 -1.249  1.00 31.79  ? 319 VAL A CG1 1 
ATOM   2491 C CG2 . VAL A 1 338 ? 28.192 -18.891 0.797   1.00 28.58  ? 319 VAL A CG2 1 
ATOM   2492 N N   . ALA A 1 339 ? 29.246 -21.980 -0.899  1.00 26.28  ? 320 ALA A N   1 
ATOM   2493 C CA  . ALA A 1 339 ? 29.412 -23.397 -0.533  1.00 27.69  ? 320 ALA A CA  1 
ATOM   2494 C C   . ALA A 1 339 ? 29.867 -23.501 0.923   1.00 29.06  ? 320 ALA A C   1 
ATOM   2495 O O   . ALA A 1 339 ? 30.475 -22.533 1.427   1.00 26.93  ? 320 ALA A O   1 
ATOM   2496 C CB  . ALA A 1 339 ? 30.441 -24.012 -1.437  1.00 27.30  ? 320 ALA A CB  1 
ATOM   2497 N N   . ASP A 1 340 ? 29.724 -24.688 1.505   1.00 27.86  ? 321 ASP A N   1 
ATOM   2498 C CA  . ASP A 1 340 ? 30.492 -25.048 2.722   1.00 30.55  ? 321 ASP A CA  1 
ATOM   2499 C C   . ASP A 1 340 ? 31.972 -24.988 2.385   1.00 28.99  ? 321 ASP A C   1 
ATOM   2500 O O   . ASP A 1 340 ? 32.361 -25.230 1.247   1.00 23.47  ? 321 ASP A O   1 
ATOM   2501 C CB  . ASP A 1 340 ? 30.127 -26.422 3.281   1.00 32.42  ? 321 ASP A CB  1 
ATOM   2502 C CG  . ASP A 1 340 ? 28.667 -26.496 3.673   1.00 36.38  ? 321 ASP A CG  1 
ATOM   2503 O OD1 . ASP A 1 340 ? 28.063 -25.414 3.880   1.00 34.53  ? 321 ASP A OD1 1 
ATOM   2504 O OD2 . ASP A 1 340 ? 28.143 -27.628 3.760   1.00 45.92  ? 321 ASP A OD2 1 
ATOM   2505 N N   . PRO A 1 341 ? 32.833 -24.658 3.370   1.00 30.01  ? 322 PRO A N   1 
ATOM   2506 C CA  . PRO A 1 341 ? 34.271 -24.669 3.146   1.00 30.70  ? 322 PRO A CA  1 
ATOM   2507 C C   . PRO A 1 341 ? 34.645 -26.114 2.833   1.00 26.43  ? 322 PRO A C   1 
ATOM   2508 O O   . PRO A 1 341 ? 34.000 -27.028 3.289   1.00 22.69  ? 322 PRO A O   1 
ATOM   2509 C CB  . PRO A 1 341 ? 34.937 -24.137 4.421   1.00 34.33  ? 322 PRO A CB  1 
ATOM   2510 C CG  . PRO A 1 341 ? 33.774 -23.651 5.292   1.00 37.27  ? 322 PRO A CG  1 
ATOM   2511 C CD  . PRO A 1 341 ? 32.484 -24.253 4.735   1.00 34.56  ? 322 PRO A CD  1 
ATOM   2512 N N   . TYR A 1 342 ? 35.624 -26.254 1.962   1.00 26.38  ? 323 TYR A N   1 
ATOM   2513 C CA  . TYR A 1 342 ? 36.073 -27.551 1.414   1.00 28.36  ? 323 TYR A CA  1 
ATOM   2514 C C   . TYR A 1 342 ? 37.495 -27.757 1.904   1.00 29.44  ? 323 TYR A C   1 
ATOM   2515 O O   . TYR A 1 342 ? 38.350 -26.886 1.623   1.00 26.83  ? 323 TYR A O   1 
ATOM   2516 C CB  . TYR A 1 342 ? 35.956 -27.535 -0.106  1.00 28.51  ? 323 TYR A CB  1 
ATOM   2517 C CG  . TYR A 1 342 ? 36.425 -28.793 -0.785  1.00 28.25  ? 323 TYR A CG  1 
ATOM   2518 C CD1 . TYR A 1 342 ? 35.897 -30.038 -0.464  1.00 28.64  ? 323 TYR A CD1 1 
ATOM   2519 C CD2 . TYR A 1 342 ? 37.396 -28.726 -1.759  1.00 26.80  ? 323 TYR A CD2 1 
ATOM   2520 C CE1 . TYR A 1 342 ? 36.331 -31.190 -1.104  1.00 26.36  ? 323 TYR A CE1 1 
ATOM   2521 C CE2 . TYR A 1 342 ? 37.844 -29.866 -2.399  1.00 29.37  ? 323 TYR A CE2 1 
ATOM   2522 C CZ  . TYR A 1 342 ? 37.298 -31.098 -2.084  1.00 26.25  ? 323 TYR A CZ  1 
ATOM   2523 O OH  . TYR A 1 342 ? 37.752 -32.191 -2.762  1.00 25.13  ? 323 TYR A OH  1 
ATOM   2524 N N   . ASP A 1 343 ? 37.702 -28.831 2.668   1.00 30.31  ? 324 ASP A N   1 
ATOM   2525 C CA  . ASP A 1 343 ? 39.006 -29.146 3.293   1.00 32.90  ? 324 ASP A CA  1 
ATOM   2526 C C   . ASP A 1 343 ? 39.863 -29.899 2.268   1.00 27.68  ? 324 ASP A C   1 
ATOM   2527 O O   . ASP A 1 343 ? 39.562 -31.030 2.008   1.00 26.93  ? 324 ASP A O   1 
ATOM   2528 C CB  . ASP A 1 343 ? 38.809 -29.928 4.590   1.00 35.01  ? 324 ASP A CB  1 
ATOM   2529 C CG  . ASP A 1 343 ? 40.106 -30.346 5.259   1.00 36.09  ? 324 ASP A CG  1 
ATOM   2530 O OD1 . ASP A 1 343 ? 41.182 -30.196 4.644   1.00 34.50  ? 324 ASP A OD1 1 
ATOM   2531 O OD2 . ASP A 1 343 ? 40.026 -30.759 6.420   1.00 48.35  ? 324 ASP A OD2 1 
ATOM   2532 N N   . GLN A 1 344 ? 40.922 -29.282 1.762   1.00 27.43  ? 325 GLN A N   1 
ATOM   2533 C CA  . GLN A 1 344 ? 41.832 -29.888 0.752   1.00 28.68  ? 325 GLN A CA  1 
ATOM   2534 C C   . GLN A 1 344 ? 43.207 -30.168 1.356   1.00 25.17  ? 325 GLN A C   1 
ATOM   2535 O O   . GLN A 1 344 ? 44.154 -30.414 0.583   1.00 24.06  ? 325 GLN A O   1 
ATOM   2536 C CB  . GLN A 1 344 ? 41.984 -28.945 -0.442  1.00 32.65  ? 325 GLN A CB  1 
ATOM   2537 C CG  . GLN A 1 344 ? 40.696 -28.752 -1.226  1.00 36.11  ? 325 GLN A CG  1 
ATOM   2538 C CD  . GLN A 1 344 ? 40.965 -27.931 -2.465  1.00 37.19  ? 325 GLN A CD  1 
ATOM   2539 O OE1 . GLN A 1 344 ? 41.635 -28.368 -3.387  1.00 38.11  ? 325 GLN A OE1 1 
ATOM   2540 N NE2 . GLN A 1 344 ? 40.474 -26.713 -2.488  1.00 38.87  ? 325 GLN A NE2 1 
ATOM   2541 N N   . SER A 1 345 ? 43.300 -30.208 2.684   1.00 26.00  ? 326 SER A N   1 
ATOM   2542 C CA  . SER A 1 345 ? 44.563 -30.532 3.398   1.00 27.51  ? 326 SER A CA  1 
ATOM   2543 C C   . SER A 1 345 ? 45.031 -31.937 2.985   1.00 24.89  ? 326 SER A C   1 
ATOM   2544 O O   . SER A 1 345 ? 46.221 -32.159 2.961   1.00 30.44  ? 326 SER A O   1 
ATOM   2545 C CB  . SER A 1 345 ? 44.406 -30.391 4.913   1.00 26.09  ? 326 SER A CB  1 
ATOM   2546 O OG  . SER A 1 345 ? 43.473 -31.339 5.386   1.00 25.25  ? 326 SER A OG  1 
ATOM   2547 N N   . PHE A 1 346 ? 44.131 -32.829 2.570   1.00 22.32  ? 327 PHE A N   1 
ATOM   2548 C CA  . PHE A 1 346 ? 44.524 -34.164 2.048   1.00 21.81  ? 327 PHE A CA  1 
ATOM   2549 C C   . PHE A 1 346 ? 45.552 -34.029 0.919   1.00 22.68  ? 327 PHE A C   1 
ATOM   2550 O O   . PHE A 1 346 ? 46.328 -34.992 0.713   1.00 22.69  ? 327 PHE A O   1 
ATOM   2551 C CB  . PHE A 1 346 ? 43.324 -34.975 1.563   1.00 22.22  ? 327 PHE A CB  1 
ATOM   2552 C CG  . PHE A 1 346 ? 42.776 -34.549 0.231   1.00 22.69  ? 327 PHE A CG  1 
ATOM   2553 C CD1 . PHE A 1 346 ? 41.732 -33.641 0.167   1.00 23.08  ? 327 PHE A CD1 1 
ATOM   2554 C CD2 . PHE A 1 346 ? 43.325 -35.016 -0.949  1.00 24.04  ? 327 PHE A CD2 1 
ATOM   2555 C CE1 . PHE A 1 346 ? 41.220 -33.249 -1.056  1.00 23.65  ? 327 PHE A CE1 1 
ATOM   2556 C CE2 . PHE A 1 346 ? 42.807 -34.620 -2.176  1.00 23.32  ? 327 PHE A CE2 1 
ATOM   2557 C CZ  . PHE A 1 346 ? 41.762 -33.742 -2.221  1.00 22.22  ? 327 PHE A CZ  1 
ATOM   2558 N N   . GLU A 1 347 ? 45.568 -32.909 0.199   1.00 22.29  ? 328 GLU A N   1 
ATOM   2559 C CA  . GLU A 1 347 ? 46.487 -32.752 -0.956  1.00 25.79  ? 328 GLU A CA  1 
ATOM   2560 C C   . GLU A 1 347 ? 47.946 -32.888 -0.498  1.00 25.58  ? 328 GLU A C   1 
ATOM   2561 O O   . GLU A 1 347 ? 48.742 -33.361 -1.292  1.00 24.29  ? 328 GLU A O   1 
ATOM   2562 C CB  . GLU A 1 347 ? 46.311 -31.421 -1.686  1.00 26.02  ? 328 GLU A CB  1 
ATOM   2563 C CG  . GLU A 1 347 ? 45.022 -31.356 -2.492  1.00 26.99  ? 328 GLU A CG  1 
ATOM   2564 C CD  . GLU A 1 347 ? 44.958 -32.293 -3.683  1.00 27.31  ? 328 GLU A CD  1 
ATOM   2565 O OE1 . GLU A 1 347 ? 45.955 -33.005 -3.962  1.00 25.24  ? 328 GLU A OE1 1 
ATOM   2566 O OE2 . GLU A 1 347 ? 43.904 -32.290 -4.350  1.00 30.67  ? 328 GLU A OE2 1 
ATOM   2567 N N   . SER A 1 348 ? 48.271 -32.564 0.746   1.00 25.16  ? 329 SER A N   1 
ATOM   2568 C CA  . SER A 1 348 ? 49.679 -32.590 1.226   1.00 30.38  ? 329 SER A CA  1 
ATOM   2569 C C   . SER A 1 348 ? 49.965 -33.889 2.009   1.00 27.83  ? 329 SER A C   1 
ATOM   2570 O O   . SER A 1 348 ? 51.085 -34.037 2.537   1.00 30.59  ? 329 SER A O   1 
ATOM   2571 C CB  . SER A 1 348 ? 49.964 -31.369 2.046   1.00 28.17  ? 329 SER A CB  1 
ATOM   2572 O OG  . SER A 1 348 ? 49.188 -31.472 3.224   1.00 35.13  ? 329 SER A OG  1 
ATOM   2573 N N   . ARG A 1 349 ? 49.026 -34.823 2.050   1.00 23.59  ? 330 ARG A N   1 
ATOM   2574 C CA  . ARG A 1 349 ? 49.274 -36.118 2.706   1.00 25.01  ? 330 ARG A CA  1 
ATOM   2575 C C   . ARG A 1 349 ? 50.139 -36.977 1.788   1.00 23.51  ? 330 ARG A C   1 
ATOM   2576 O O   . ARG A 1 349 ? 50.007 -36.927 0.560   1.00 26.98  ? 330 ARG A O   1 
ATOM   2577 C CB  . ARG A 1 349 ? 47.971 -36.801 3.119   1.00 24.14  ? 330 ARG A CB  1 
ATOM   2578 C CG  . ARG A 1 349 ? 47.219 -36.011 4.177   1.00 24.59  ? 330 ARG A CG  1 
ATOM   2579 C CD  . ARG A 1 349 ? 45.954 -36.708 4.645   1.00 22.83  ? 330 ARG A CD  1 
ATOM   2580 N NE  . ARG A 1 349 ? 46.188 -37.817 5.551   1.00 22.15  ? 330 ARG A NE  1 
ATOM   2581 C CZ  . ARG A 1 349 ? 45.237 -38.632 5.992   1.00 22.21  ? 330 ARG A CZ  1 
ATOM   2582 N NH1 . ARG A 1 349 ? 43.990 -38.477 5.574   1.00 21.05  ? 330 ARG A NH1 1 
ATOM   2583 N NH2 . ARG A 1 349 ? 45.534 -39.585 6.860   1.00 22.20  ? 330 ARG A NH2 1 
ATOM   2584 N N   . ASP A 1 350 ? 51.025 -37.722 2.412   1.00 24.23  ? 331 ASP A N   1 
ATOM   2585 C CA  . ASP A 1 350 ? 51.944 -38.653 1.740   1.00 26.77  ? 331 ASP A CA  1 
ATOM   2586 C C   . ASP A 1 350 ? 51.574 -40.063 2.225   1.00 24.78  ? 331 ASP A C   1 
ATOM   2587 O O   . ASP A 1 350 ? 51.998 -40.461 3.341   1.00 27.97  ? 331 ASP A O   1 
ATOM   2588 C CB  . ASP A 1 350 ? 53.371 -38.189 2.015   1.00 30.92  ? 331 ASP A CB  1 
ATOM   2589 C CG  . ASP A 1 350 ? 54.394 -39.056 1.311   1.00 35.13  ? 331 ASP A CG  1 
ATOM   2590 O OD1 . ASP A 1 350 ? 54.358 -39.092 0.067   1.00 41.45  ? 331 ASP A OD1 1 
ATOM   2591 O OD2 . ASP A 1 350 ? 55.157 -39.739 2.015   1.00 43.62  ? 331 ASP A OD2 1 
ATOM   2592 N N   . LEU A 1 351 ? 50.774 -40.777 1.450   1.00 22.37  ? 332 LEU A N   1 
ATOM   2593 C CA  . LEU A 1 351 ? 50.144 -42.059 1.867   1.00 23.68  ? 332 LEU A CA  1 
ATOM   2594 C C   . LEU A 1 351 ? 50.429 -43.157 0.838   1.00 23.79  ? 332 LEU A C   1 
ATOM   2595 O O   . LEU A 1 351 ? 50.799 -42.855 -0.327  1.00 24.41  ? 332 LEU A O   1 
ATOM   2596 C CB  . LEU A 1 351 ? 48.631 -41.867 2.008   1.00 23.98  ? 332 LEU A CB  1 
ATOM   2597 C CG  . LEU A 1 351 ? 48.153 -40.676 2.842   1.00 23.93  ? 332 LEU A CG  1 
ATOM   2598 C CD1 . LEU A 1 351 ? 46.624 -40.650 2.905   1.00 22.67  ? 332 LEU A CD1 1 
ATOM   2599 C CD2 . LEU A 1 351 ? 48.704 -40.728 4.275   1.00 23.68  ? 332 LEU A CD2 1 
ATOM   2600 N N   . LEU A 1 352 ? 50.235 -44.385 1.283   1.00 24.40  ? 333 LEU A N   1 
ATOM   2601 C CA  . LEU A 1 352 ? 50.361 -45.641 0.499   1.00 25.56  ? 333 LEU A CA  1 
ATOM   2602 C C   . LEU A 1 352 ? 49.156 -45.762 -0.429  1.00 26.80  ? 333 LEU A C   1 
ATOM   2603 O O   . LEU A 1 352 ? 48.065 -45.281 -0.079  1.00 24.17  ? 333 LEU A O   1 
ATOM   2604 C CB  . LEU A 1 352 ? 50.359 -46.826 1.465   1.00 24.91  ? 333 LEU A CB  1 
ATOM   2605 C CG  . LEU A 1 352 ? 51.488 -46.877 2.492   1.00 27.07  ? 333 LEU A CG  1 
ATOM   2606 C CD1 . LEU A 1 352 ? 51.298 -48.066 3.456   1.00 25.11  ? 333 LEU A CD1 1 
ATOM   2607 C CD2 . LEU A 1 352 ? 52.840 -46.944 1.790   1.00 27.70  ? 333 LEU A CD2 1 
ATOM   2608 N N   . ILE A 1 353 ? 49.325 -46.481 -1.528  1.00 29.16  ? 334 ILE A N   1 
ATOM   2609 C CA  . ILE A 1 353 ? 48.211 -46.819 -2.461  1.00 28.93  ? 334 ILE A CA  1 
ATOM   2610 C C   . ILE A 1 353 ? 47.010 -47.287 -1.636  1.00 27.01  ? 334 ILE A C   1 
ATOM   2611 O O   . ILE A 1 353 ? 45.922 -46.734 -1.833  1.00 26.25  ? 334 ILE A O   1 
ATOM   2612 C CB  . ILE A 1 353 ? 48.686 -47.876 -3.478  1.00 31.59  ? 334 ILE A CB  1 
ATOM   2613 C CG1 . ILE A 1 353 ? 49.763 -47.304 -4.402  1.00 33.08  ? 334 ILE A CG1 1 
ATOM   2614 C CG2 . ILE A 1 353 ? 47.530 -48.446 -4.276  1.00 30.27  ? 334 ILE A CG2 1 
ATOM   2615 C CD1 . ILE A 1 353 ? 50.552 -48.381 -5.154  1.00 37.47  ? 334 ILE A CD1 1 
ATOM   2616 N N   . ASP A 1 354 ? 47.205 -48.276 -0.759  1.00 29.08  ? 335 ASP A N   1 
ATOM   2617 C CA  . ASP A 1 354 ? 46.105 -48.941 -0.005  1.00 31.96  ? 335 ASP A CA  1 
ATOM   2618 C C   . ASP A 1 354 ? 45.484 -47.956 1.009   1.00 28.46  ? 335 ASP A C   1 
ATOM   2619 O O   . ASP A 1 354 ? 44.293 -48.102 1.346   1.00 27.01  ? 335 ASP A O   1 
ATOM   2620 C CB  . ASP A 1 354 ? 46.575 -50.260 0.621   1.00 37.92  ? 335 ASP A CB  1 
ATOM   2621 C CG  . ASP A 1 354 ? 46.592 -51.473 -0.316  1.00 47.46  ? 335 ASP A CG  1 
ATOM   2622 O OD1 . ASP A 1 354 ? 46.072 -51.390 -1.472  1.00 48.05  ? 335 ASP A OD1 1 
ATOM   2623 O OD2 . ASP A 1 354 ? 47.095 -52.523 0.130   1.00 60.47  ? 335 ASP A OD2 1 
ATOM   2624 N N   . GLU A 1 355 ? 46.226 -46.945 1.450   1.00 25.04  ? 336 GLU A N   1 
ATOM   2625 C CA  . GLU A 1 355 ? 45.680 -45.887 2.329   1.00 22.62  ? 336 GLU A CA  1 
ATOM   2626 C C   . GLU A 1 355 ? 44.772 -44.947 1.499   1.00 23.27  ? 336 GLU A C   1 
ATOM   2627 O O   . GLU A 1 355 ? 43.660 -44.655 1.931   1.00 22.48  ? 336 GLU A O   1 
ATOM   2628 C CB  . GLU A 1 355 ? 46.827 -45.162 3.027   1.00 22.13  ? 336 GLU A CB  1 
ATOM   2629 C CG  . GLU A 1 355 ? 47.418 -45.939 4.180   1.00 22.40  ? 336 GLU A CG  1 
ATOM   2630 C CD  . GLU A 1 355 ? 48.635 -45.263 4.777   1.00 22.01  ? 336 GLU A CD  1 
ATOM   2631 O OE1 . GLU A 1 355 ? 49.325 -44.523 4.071   1.00 22.09  ? 336 GLU A OE1 1 
ATOM   2632 O OE2 . GLU A 1 355 ? 48.838 -45.404 5.971   1.00 24.30  ? 336 GLU A OE2 1 
ATOM   2633 N N   . TRP A 1 356 ? 45.212 -44.481 0.340   1.00 22.21  ? 337 TRP A N   1 
ATOM   2634 C CA  . TRP A 1 356 ? 44.330 -43.711 -0.578  1.00 22.58  ? 337 TRP A CA  1 
ATOM   2635 C C   . TRP A 1 356 ? 43.094 -44.548 -0.922  1.00 22.16  ? 337 TRP A C   1 
ATOM   2636 O O   . TRP A 1 356 ? 41.999 -44.006 -0.911  1.00 24.78  ? 337 TRP A O   1 
ATOM   2637 C CB  . TRP A 1 356 ? 45.085 -43.314 -1.834  1.00 20.38  ? 337 TRP A CB  1 
ATOM   2638 C CG  . TRP A 1 356 ? 46.079 -42.244 -1.586  1.00 20.27  ? 337 TRP A CG  1 
ATOM   2639 C CD1 . TRP A 1 356 ? 47.424 -42.311 -1.814  1.00 21.19  ? 337 TRP A CD1 1 
ATOM   2640 C CD2 . TRP A 1 356 ? 45.795 -40.920 -1.112  1.00 20.83  ? 337 TRP A CD2 1 
ATOM   2641 N NE1 . TRP A 1 356 ? 48.001 -41.115 -1.500  1.00 21.73  ? 337 TRP A NE1 1 
ATOM   2642 C CE2 . TRP A 1 356 ? 47.027 -40.238 -1.068  1.00 20.64  ? 337 TRP A CE2 1 
ATOM   2643 C CE3 . TRP A 1 356 ? 44.631 -40.250 -0.723  1.00 22.24  ? 337 TRP A CE3 1 
ATOM   2644 C CZ2 . TRP A 1 356 ? 47.136 -38.927 -0.625  1.00 20.78  ? 337 TRP A CZ2 1 
ATOM   2645 C CZ3 . TRP A 1 356 ? 44.740 -38.946 -0.269  1.00 22.39  ? 337 TRP A CZ3 1 
ATOM   2646 C CH2 . TRP A 1 356 ? 45.980 -38.303 -0.221  1.00 22.93  ? 337 TRP A CH2 1 
ATOM   2647 N N   . LYS A 1 357 ? 43.294 -45.837 -1.187  1.00 23.66  ? 338 LYS A N   1 
ATOM   2648 C CA  . LYS A 1 357 ? 42.203 -46.767 -1.553  1.00 27.80  ? 338 LYS A CA  1 
ATOM   2649 C C   . LYS A 1 357 ? 41.190 -46.842 -0.413  1.00 27.59  ? 338 LYS A C   1 
ATOM   2650 O O   . LYS A 1 357 ? 40.015 -46.739 -0.674  1.00 28.31  ? 338 LYS A O   1 
ATOM   2651 C CB  . LYS A 1 357 ? 42.785 -48.139 -1.856  1.00 30.47  ? 338 LYS A CB  1 
ATOM   2652 C CG  . LYS A 1 357 ? 41.768 -49.217 -2.200  1.00 32.57  ? 338 LYS A CG  1 
ATOM   2653 C CD  . LYS A 1 357 ? 42.508 -50.451 -2.588  1.00 35.74  ? 338 LYS A CD  1 
ATOM   2654 C CE  . LYS A 1 357 ? 41.750 -51.738 -2.445  1.00 43.86  ? 338 LYS A CE  1 
ATOM   2655 N NZ  . LYS A 1 357 ? 42.391 -52.780 -3.288  1.00 48.43  ? 338 LYS A NZ  1 
ATOM   2656 N N   . SER A 1 358 ? 41.663 -47.064 0.804   1.00 24.25  ? 339 SER A N   1 
ATOM   2657 C CA  . SER A 1 358 ? 40.819 -47.158 2.010   1.00 23.71  ? 339 SER A CA  1 
ATOM   2658 C C   . SER A 1 358 ? 40.029 -45.852 2.237   1.00 22.61  ? 339 SER A C   1 
ATOM   2659 O O   . SER A 1 358 ? 38.815 -45.933 2.496   1.00 22.83  ? 339 SER A O   1 
ATOM   2660 C CB  . SER A 1 358 ? 41.697 -47.513 3.188   1.00 23.44  ? 339 SER A CB  1 
ATOM   2661 O OG  . SER A 1 358 ? 40.909 -47.539 4.341   1.00 25.53  ? 339 SER A OG  1 
ATOM   2662 N N   . LEU A 1 359 ? 40.683 -44.691 2.178   1.00 22.11  ? 340 LEU A N   1 
ATOM   2663 C CA  . LEU A 1 359 ? 40.008 -43.368 2.261   1.00 23.92  ? 340 LEU A CA  1 
ATOM   2664 C C   . LEU A 1 359 ? 38.920 -43.293 1.190   1.00 23.82  ? 340 LEU A C   1 
ATOM   2665 O O   . LEU A 1 359 ? 37.856 -42.758 1.478   1.00 23.30  ? 340 LEU A O   1 
ATOM   2666 C CB  . LEU A 1 359 ? 41.019 -42.246 2.030   1.00 22.61  ? 340 LEU A CB  1 
ATOM   2667 C CG  . LEU A 1 359 ? 41.904 -41.922 3.220   1.00 25.52  ? 340 LEU A CG  1 
ATOM   2668 C CD1 . LEU A 1 359 ? 43.055 -41.051 2.769   1.00 25.35  ? 340 LEU A CD1 1 
ATOM   2669 C CD2 . LEU A 1 359 ? 41.099 -41.247 4.337   1.00 26.63  ? 340 LEU A CD2 1 
ATOM   2670 N N   . THR A 1 360 ? 39.216 -43.730 -0.036  1.00 23.45  ? 341 THR A N   1 
ATOM   2671 C CA  . THR A 1 360 ? 38.236 -43.676 -1.143  1.00 23.24  ? 341 THR A CA  1 
ATOM   2672 C C   . THR A 1 360 ? 37.027 -44.534 -0.771  1.00 25.57  ? 341 THR A C   1 
ATOM   2673 O O   . THR A 1 360 ? 35.855 -44.079 -0.974  1.00 22.57  ? 341 THR A O   1 
ATOM   2674 C CB  . THR A 1 360 ? 38.853 -44.144 -2.461  1.00 25.00  ? 341 THR A CB  1 
ATOM   2675 O OG1 . THR A 1 360 ? 39.905 -43.234 -2.750  1.00 22.75  ? 341 THR A OG1 1 
ATOM   2676 C CG2 . THR A 1 360 ? 37.862 -44.188 -3.603  1.00 25.95  ? 341 THR A CG2 1 
ATOM   2677 N N   . TYR A 1 361 ? 37.301 -45.732 -0.254  1.00 26.11  ? 342 TYR A N   1 
ATOM   2678 C CA  . TYR A 1 361 ? 36.267 -46.722 0.140   1.00 27.37  ? 342 TYR A CA  1 
ATOM   2679 C C   . TYR A 1 361 ? 35.372 -46.101 1.213   1.00 25.14  ? 342 TYR A C   1 
ATOM   2680 O O   . TYR A 1 361 ? 34.138 -46.209 1.132   1.00 24.52  ? 342 TYR A O   1 
ATOM   2681 C CB  . TYR A 1 361 ? 36.913 -48.025 0.613   1.00 28.30  ? 342 TYR A CB  1 
ATOM   2682 C CG  . TYR A 1 361 ? 35.928 -49.134 0.861   1.00 28.31  ? 342 TYR A CG  1 
ATOM   2683 C CD1 . TYR A 1 361 ? 35.184 -49.681 -0.164  1.00 27.03  ? 342 TYR A CD1 1 
ATOM   2684 C CD2 . TYR A 1 361 ? 35.720 -49.621 2.145   1.00 34.17  ? 342 TYR A CD2 1 
ATOM   2685 C CE1 . TYR A 1 361 ? 34.307 -50.725 0.076   1.00 27.89  ? 342 TYR A CE1 1 
ATOM   2686 C CE2 . TYR A 1 361 ? 34.809 -50.628 2.408   1.00 29.47  ? 342 TYR A CE2 1 
ATOM   2687 C CZ  . TYR A 1 361 ? 34.108 -51.191 1.366   1.00 29.08  ? 342 TYR A CZ  1 
ATOM   2688 O OH  . TYR A 1 361 ? 33.212 -52.183 1.643   1.00 30.83  ? 342 TYR A OH  1 
ATOM   2689 N N   . ASP A 1 362 ? 35.978 -45.467 2.208   1.00 25.80  ? 343 ASP A N   1 
ATOM   2690 C CA  . ASP A 1 362 ? 35.219 -44.766 3.286   1.00 28.34  ? 343 ASP A CA  1 
ATOM   2691 C C   . ASP A 1 362 ? 34.263 -43.741 2.657   1.00 31.41  ? 343 ASP A C   1 
ATOM   2692 O O   . ASP A 1 362 ? 33.097 -43.679 3.082   1.00 33.01  ? 343 ASP A O   1 
ATOM   2693 C CB  . ASP A 1 362 ? 36.138 -44.091 4.304   1.00 27.49  ? 343 ASP A CB  1 
ATOM   2694 C CG  . ASP A 1 362 ? 36.942 -45.060 5.172   1.00 30.24  ? 343 ASP A CG  1 
ATOM   2695 O OD1 . ASP A 1 362 ? 36.672 -46.294 5.129   1.00 27.67  ? 343 ASP A OD1 1 
ATOM   2696 O OD2 . ASP A 1 362 ? 37.887 -44.580 5.820   1.00 33.60  ? 343 ASP A OD2 1 
ATOM   2697 N N   . GLU A 1 363 ? 34.713 -42.987 1.652   1.00 28.25  ? 344 GLU A N   1 
ATOM   2698 C CA  . GLU A 1 363 ? 33.882 -41.939 1.012   1.00 27.12  ? 344 GLU A CA  1 
ATOM   2699 C C   . GLU A 1 363 ? 32.755 -42.584 0.214   1.00 26.79  ? 344 GLU A C   1 
ATOM   2700 O O   . GLU A 1 363 ? 31.645 -42.011 0.178   1.00 25.72  ? 344 GLU A O   1 
ATOM   2701 C CB  . GLU A 1 363 ? 34.774 -41.053 0.156   1.00 28.25  ? 344 GLU A CB  1 
ATOM   2702 C CG  . GLU A 1 363 ? 35.722 -40.248 1.014   1.00 26.64  ? 344 GLU A CG  1 
ATOM   2703 C CD  . GLU A 1 363 ? 35.080 -39.145 1.826   1.00 26.22  ? 344 GLU A CD  1 
ATOM   2704 O OE1 . GLU A 1 363 ? 33.948 -38.738 1.482   1.00 28.44  ? 344 GLU A OE1 1 
ATOM   2705 O OE2 . GLU A 1 363 ? 35.744 -38.655 2.767   1.00 29.77  ? 344 GLU A OE2 1 
ATOM   2706 N N   . VAL A 1 364 ? 32.989 -43.766 -0.346  1.00 27.02  ? 345 VAL A N   1 
ATOM   2707 C CA  . VAL A 1 364 ? 31.902 -44.518 -1.025  1.00 26.47  ? 345 VAL A CA  1 
ATOM   2708 C C   . VAL A 1 364 ? 30.872 -44.848 0.065   1.00 29.83  ? 345 VAL A C   1 
ATOM   2709 O O   . VAL A 1 364 ? 29.681 -44.559 -0.127  1.00 26.33  ? 345 VAL A O   1 
ATOM   2710 C CB  . VAL A 1 364 ? 32.404 -45.784 -1.743  1.00 25.69  ? 345 VAL A CB  1 
ATOM   2711 C CG1 . VAL A 1 364 ? 31.236 -46.621 -2.257  1.00 28.56  ? 345 VAL A CG1 1 
ATOM   2712 C CG2 . VAL A 1 364 ? 33.356 -45.468 -2.885  1.00 23.67  ? 345 VAL A CG2 1 
ATOM   2713 N N   . ILE A 1 365 ? 31.344 -45.369 1.202   1.00 32.20  ? 346 ILE A N   1 
ATOM   2714 C CA  . ILE A 1 365 ? 30.493 -45.884 2.320   1.00 31.90  ? 346 ILE A CA  1 
ATOM   2715 C C   . ILE A 1 365 ? 29.691 -44.716 2.875   1.00 32.05  ? 346 ILE A C   1 
ATOM   2716 O O   . ILE A 1 365 ? 28.512 -44.908 3.112   1.00 35.65  ? 346 ILE A O   1 
ATOM   2717 C CB  . ILE A 1 365 ? 31.328 -46.607 3.406   1.00 32.45  ? 346 ILE A CB  1 
ATOM   2718 C CG1 . ILE A 1 365 ? 31.967 -47.879 2.845   1.00 33.83  ? 346 ILE A CG1 1 
ATOM   2719 C CG2 . ILE A 1 365 ? 30.519 -46.916 4.672   1.00 33.51  ? 346 ILE A CG2 1 
ATOM   2720 C CD1 . ILE A 1 365 ? 30.978 -48.790 2.137   1.00 33.44  ? 346 ILE A CD1 1 
ATOM   2721 N N   . SER A 1 366 ? 30.307 -43.548 3.043   1.00 32.54  ? 347 SER A N   1 
ATOM   2722 C CA  . SER A 1 366 ? 29.662 -42.420 3.749   1.00 31.25  ? 347 SER A CA  1 
ATOM   2723 C C   . SER A 1 366 ? 28.776 -41.603 2.802   1.00 36.71  ? 347 SER A C   1 
ATOM   2724 O O   . SER A 1 366 ? 28.243 -40.576 3.263   1.00 37.90  ? 347 SER A O   1 
ATOM   2725 C CB  . SER A 1 366 ? 30.687 -41.575 4.417   1.00 31.94  ? 347 SER A CB  1 
ATOM   2726 O OG  . SER A 1 366 ? 31.532 -40.960 3.465   1.00 30.67  ? 347 SER A OG  1 
ATOM   2727 N N   . PHE A 1 367 ? 28.612 -42.034 1.542   1.00 37.18  ? 348 PHE A N   1 
ATOM   2728 C CA  . PHE A 1 367 ? 27.871 -41.281 0.503   1.00 35.96  ? 348 PHE A CA  1 
ATOM   2729 C C   . PHE A 1 367 ? 26.385 -41.234 0.879   1.00 37.74  ? 348 PHE A C   1 
ATOM   2730 O O   . PHE A 1 367 ? 25.793 -42.297 1.033   1.00 37.16  ? 348 PHE A O   1 
ATOM   2731 C CB  . PHE A 1 367 ? 27.983 -41.919 -0.884  1.00 32.59  ? 348 PHE A CB  1 
ATOM   2732 C CG  . PHE A 1 367 ? 27.168 -41.184 -1.907  1.00 32.35  ? 348 PHE A CG  1 
ATOM   2733 C CD1 . PHE A 1 367 ? 27.433 -39.858 -2.192  1.00 34.60  ? 348 PHE A CD1 1 
ATOM   2734 C CD2 . PHE A 1 367 ? 26.073 -41.779 -2.504  1.00 35.76  ? 348 PHE A CD2 1 
ATOM   2735 C CE1 . PHE A 1 367 ? 26.665 -39.158 -3.109  1.00 34.92  ? 348 PHE A CE1 1 
ATOM   2736 C CE2 . PHE A 1 367 ? 25.297 -41.080 -3.420  1.00 35.49  ? 348 PHE A CE2 1 
ATOM   2737 C CZ  . PHE A 1 367 ? 25.597 -39.766 -3.720  1.00 34.39  ? 348 PHE A CZ  1 
ATOM   2738 N N   . VAL A 1 368 ? 25.803 -40.039 0.972   1.00 38.60  ? 349 VAL A N   1 
ATOM   2739 C CA  . VAL A 1 368 ? 24.332 -39.847 1.154   1.00 39.93  ? 349 VAL A CA  1 
ATOM   2740 C C   . VAL A 1 368 ? 23.747 -39.355 -0.168  1.00 37.71  ? 349 VAL A C   1 
ATOM   2741 O O   . VAL A 1 368 ? 24.075 -38.263 -0.607  1.00 34.85  ? 349 VAL A O   1 
ATOM   2742 C CB  . VAL A 1 368 ? 24.055 -38.846 2.289   1.00 43.33  ? 349 VAL A CB  1 
ATOM   2743 C CG1 . VAL A 1 368 ? 22.564 -38.725 2.586   1.00 41.48  ? 349 VAL A CG1 1 
ATOM   2744 C CG2 . VAL A 1 368 ? 24.823 -39.221 3.554   1.00 48.23  ? 349 VAL A CG2 1 
ATOM   2745 N N   . PRO A 1 369 ? 22.869 -40.109 -0.853  1.00 36.86  ? 350 PRO A N   1 
ATOM   2746 C CA  . PRO A 1 369 ? 22.285 -39.634 -2.102  1.00 45.48  ? 350 PRO A CA  1 
ATOM   2747 C C   . PRO A 1 369 ? 21.535 -38.326 -1.920  1.00 50.03  ? 350 PRO A C   1 
ATOM   2748 O O   . PRO A 1 369 ? 21.075 -38.016 -0.824  1.00 46.61  ? 350 PRO A O   1 
ATOM   2749 C CB  . PRO A 1 369 ? 21.272 -40.709 -2.530  1.00 45.60  ? 350 PRO A CB  1 
ATOM   2750 C CG  . PRO A 1 369 ? 21.102 -41.590 -1.313  1.00 44.11  ? 350 PRO A CG  1 
ATOM   2751 C CD  . PRO A 1 369 ? 22.357 -41.430 -0.477  1.00 42.83  ? 350 PRO A CD  1 
ATOM   2752 N N   . PRO A 1 370 ? 21.405 -37.521 -2.993  1.00 57.37  ? 351 PRO A N   1 
ATOM   2753 C CA  . PRO A 1 370 ? 20.577 -36.320 -2.953  1.00 62.31  ? 351 PRO A CA  1 
ATOM   2754 C C   . PRO A 1 370 ? 19.113 -36.678 -2.685  1.00 64.27  ? 351 PRO A C   1 
ATOM   2755 O O   . PRO A 1 370 ? 18.660 -37.749 -3.084  1.00 52.23  ? 351 PRO A O   1 
ATOM   2756 C CB  . PRO A 1 370 ? 20.725 -35.704 -4.352  1.00 65.48  ? 351 PRO A CB  1 
ATOM   2757 C CG  . PRO A 1 370 ? 21.943 -36.382 -4.953  1.00 65.02  ? 351 PRO A CG  1 
ATOM   2758 C CD  . PRO A 1 370 ? 22.021 -37.748 -4.307  1.00 60.49  ? 351 PRO A CD  1 
ATOM   2759 N N   . PRO A 1 371 ? 18.337 -35.811 -1.988  1.00 75.54  ? 352 PRO A N   1 
ATOM   2760 C CA  . PRO A 1 371 ? 16.896 -36.031 -1.824  1.00 77.01  ? 352 PRO A CA  1 
ATOM   2761 C C   . PRO A 1 371 ? 16.136 -36.059 -3.160  1.00 74.15  ? 352 PRO A C   1 
ATOM   2762 O O   . PRO A 1 371 ? 16.596 -35.423 -4.092  1.00 66.74  ? 352 PRO A O   1 
ATOM   2763 C CB  . PRO A 1 371 ? 16.445 -34.819 -0.987  1.00 78.08  ? 352 PRO A CB  1 
ATOM   2764 C CG  . PRO A 1 371 ? 17.706 -34.350 -0.276  1.00 73.58  ? 352 PRO A CG  1 
ATOM   2765 C CD  . PRO A 1 371 ? 18.805 -34.597 -1.288  1.00 75.63  ? 352 PRO A CD  1 
ATOM   2766 N N   . LEU A 1 372 ? 15.008 -36.781 -3.216  1.00 86.53  ? 353 LEU A N   1 
ATOM   2767 C CA  . LEU A 1 372 ? 14.002 -36.711 -4.320  1.00 95.43  ? 353 LEU A CA  1 
ATOM   2768 C C   . LEU A 1 372 ? 14.549 -37.470 -5.536  1.00 94.59  ? 353 LEU A C   1 
ATOM   2769 O O   . LEU A 1 372 ? 13.806 -37.911 -6.411  1.00 82.98  ? 353 LEU A O   1 
ATOM   2770 C CB  . LEU A 1 372 ? 13.714 -35.233 -4.645  1.00 98.78  ? 353 LEU A CB  1 
ATOM   2771 C CG  . LEU A 1 372 ? 12.840 -34.936 -5.866  1.00 101.13 ? 353 LEU A CG  1 
ATOM   2772 C CD1 . LEU A 1 372 ? 11.369 -35.189 -5.560  1.00 104.58 ? 353 LEU A CD1 1 
ATOM   2773 C CD2 . LEU A 1 372 ? 13.045 -33.505 -6.347  1.00 96.65  ? 353 LEU A CD2 1 
ATOM   2774 N N   . ARG B 2 1   ? 13.457 -20.120 -9.660  1.00 88.28  ? 16  ARG B N   1 
ATOM   2775 C CA  . ARG B 2 1   ? 12.917 -18.757 -9.994  1.00 95.12  ? 16  ARG B CA  1 
ATOM   2776 C C   . ARG B 2 1   ? 13.614 -18.165 -11.238 1.00 96.49  ? 16  ARG B C   1 
ATOM   2777 O O   . ARG B 2 1   ? 13.321 -17.004 -11.570 1.00 96.46  ? 16  ARG B O   1 
ATOM   2778 C CB  . ARG B 2 1   ? 13.029 -17.827 -8.775  1.00 97.29  ? 16  ARG B CB  1 
ATOM   2779 C CG  . ARG B 2 1   ? 14.433 -17.623 -8.219  1.00 96.44  ? 16  ARG B CG  1 
ATOM   2780 C CD  . ARG B 2 1   ? 15.209 -16.465 -8.827  1.00 90.77  ? 16  ARG B CD  1 
ATOM   2781 N NE  . ARG B 2 1   ? 16.646 -16.672 -8.645  1.00 83.38  ? 16  ARG B NE  1 
ATOM   2782 C CZ  . ARG B 2 1   ? 17.615 -16.078 -9.345  1.00 83.19  ? 16  ARG B CZ  1 
ATOM   2783 N NH1 . ARG B 2 1   ? 17.310 -15.199 -10.292 1.00 79.13  ? 16  ARG B NH1 1 
ATOM   2784 N NH2 . ARG B 2 1   ? 18.889 -16.374 -9.094  1.00 67.92  ? 16  ARG B NH2 1 
ATOM   2785 N N   . LEU B 2 2   ? 14.467 -18.923 -11.937 1.00 96.85  ? 17  LEU B N   1 
ATOM   2786 C CA  . LEU B 2 2   ? 15.266 -18.418 -13.095 1.00 94.05  ? 17  LEU B CA  1 
ATOM   2787 C C   . LEU B 2 2   ? 14.445 -18.442 -14.401 1.00 94.26  ? 17  LEU B C   1 
ATOM   2788 O O   . LEU B 2 2   ? 14.583 -17.479 -15.200 1.00 88.76  ? 17  LEU B O   1 
ATOM   2789 C CB  . LEU B 2 2   ? 16.564 -19.233 -13.193 1.00 88.16  ? 17  LEU B CB  1 
ATOM   2790 C CG  . LEU B 2 2   ? 17.637 -18.833 -12.175 1.00 77.47  ? 17  LEU B CG  1 
ATOM   2791 C CD1 . LEU B 2 2   ? 18.845 -19.755 -12.222 1.00 69.25  ? 17  LEU B CD1 1 
ATOM   2792 C CD2 . LEU B 2 2   ? 18.059 -17.385 -12.390 1.00 77.14  ? 17  LEU B CD2 1 
ATOM   2793 N N   . GLN B 2 3   ? 13.600 -19.464 -14.601 1.00 93.21  ? 18  GLN B N   1 
ATOM   2794 C CA  . GLN B 2 3   ? 12.743 -19.628 -15.813 1.00 90.12  ? 18  GLN B CA  1 
ATOM   2795 C C   . GLN B 2 3   ? 11.700 -18.501 -15.881 1.00 91.24  ? 18  GLN B C   1 
ATOM   2796 O O   . GLN B 2 3   ? 11.396 -18.055 -17.011 1.00 91.63  ? 18  GLN B O   1 
ATOM   2797 C CB  . GLN B 2 3   ? 12.054 -21.000 -15.846 1.00 85.76  ? 18  GLN B CB  1 
ATOM   2798 C CG  . GLN B 2 3   ? 12.991 -22.169 -16.145 1.00 89.04  ? 18  GLN B CG  1 
ATOM   2799 C CD  . GLN B 2 3   ? 13.926 -21.954 -17.317 1.00 87.09  ? 18  GLN B CD  1 
ATOM   2800 O OE1 . GLN B 2 3   ? 13.519 -21.593 -18.423 1.00 77.93  ? 18  GLN B OE1 1 
ATOM   2801 N NE2 . GLN B 2 3   ? 15.204 -22.205 -17.087 1.00 84.42  ? 18  GLN B NE2 1 
ATOM   2802 N N   . GLU B 2 4   ? 11.177 -18.054 -14.735 1.00 93.07  ? 19  GLU B N   1 
ATOM   2803 C CA  . GLU B 2 4   ? 10.205 -16.928 -14.664 1.00 104.54 ? 19  GLU B CA  1 
ATOM   2804 C C   . GLU B 2 4   ? 10.905 -15.640 -15.137 1.00 98.68  ? 19  GLU B C   1 
ATOM   2805 O O   . GLU B 2 4   ? 10.234 -14.823 -15.806 1.00 88.10  ? 19  GLU B O   1 
ATOM   2806 C CB  . GLU B 2 4   ? 9.591  -16.820 -13.258 1.00 115.21 ? 19  GLU B CB  1 
ATOM   2807 C CG  . GLU B 2 4   ? 10.510 -16.187 -12.222 1.00 121.01 ? 19  GLU B CG  1 
ATOM   2808 C CD  . GLU B 2 4   ? 9.977  -16.080 -10.800 1.00 123.25 ? 19  GLU B CD  1 
ATOM   2809 O OE1 . GLU B 2 4   ? 8.934  -16.697 -10.500 1.00 133.84 ? 19  GLU B OE1 1 
ATOM   2810 O OE2 . GLU B 2 4   ? 10.629 -15.395 -9.984  1.00 107.04 ? 19  GLU B OE2 1 
ATOM   2811 N N   . ARG B 2 5   ? 12.209 -15.490 -14.851 1.00 96.59  ? 20  ARG B N   1 
ATOM   2812 C CA  . ARG B 2 5   ? 13.010 -14.263 -15.150 1.00 94.96  ? 20  ARG B CA  1 
ATOM   2813 C C   . ARG B 2 5   ? 13.341 -14.141 -16.654 1.00 85.58  ? 20  ARG B C   1 
ATOM   2814 O O   . ARG B 2 5   ? 13.672 -13.009 -17.070 1.00 71.61  ? 20  ARG B O   1 
ATOM   2815 C CB  . ARG B 2 5   ? 14.307 -14.240 -14.328 1.00 98.30  ? 20  ARG B CB  1 
ATOM   2816 C CG  . ARG B 2 5   ? 14.127 -14.151 -12.817 1.00 101.70 ? 20  ARG B CG  1 
ATOM   2817 C CD  . ARG B 2 5   ? 13.423 -12.893 -12.341 1.00 109.36 ? 20  ARG B CD  1 
ATOM   2818 N NE  . ARG B 2 5   ? 13.953 -11.653 -12.901 1.00 107.92 ? 20  ARG B NE  1 
ATOM   2819 C CZ  . ARG B 2 5   ? 13.323 -10.476 -12.882 1.00 108.05 ? 20  ARG B CZ  1 
ATOM   2820 N NH1 . ARG B 2 5   ? 12.127 -10.355 -12.328 1.00 113.00 ? 20  ARG B NH1 1 
ATOM   2821 N NH2 . ARG B 2 5   ? 13.897 -9.415  -13.419 1.00 103.10 ? 20  ARG B NH2 1 
ATOM   2822 N N   . ARG B 2 6   ? 13.284 -15.236 -17.435 1.00 82.78  ? 21  ARG B N   1 
ATOM   2823 C CA  . ARG B 2 6   ? 13.709 -15.272 -18.870 1.00 78.36  ? 21  ARG B CA  1 
ATOM   2824 C C   . ARG B 2 6   ? 12.714 -14.502 -19.752 1.00 87.37  ? 21  ARG B C   1 
ATOM   2825 O O   . ARG B 2 6   ? 11.487 -14.578 -19.491 1.00 90.86  ? 21  ARG B O   1 
ATOM   2826 C CB  . ARG B 2 6   ? 13.828 -16.707 -19.392 1.00 68.64  ? 21  ARG B CB  1 
ATOM   2827 C CG  . ARG B 2 6   ? 14.960 -17.512 -18.775 1.00 65.88  ? 21  ARG B CG  1 
ATOM   2828 C CD  . ARG B 2 6   ? 14.983 -18.896 -19.389 1.00 59.39  ? 21  ARG B CD  1 
ATOM   2829 N NE  . ARG B 2 6   ? 15.380 -18.857 -20.796 1.00 51.74  ? 21  ARG B NE  1 
ATOM   2830 C CZ  . ARG B 2 6   ? 15.039 -19.763 -21.722 1.00 59.41  ? 21  ARG B CZ  1 
ATOM   2831 N NH1 . ARG B 2 6   ? 14.270 -20.794 -21.398 1.00 62.54  ? 21  ARG B NH1 1 
ATOM   2832 N NH2 . ARG B 2 6   ? 15.447 -19.626 -22.981 1.00 52.62  ? 21  ARG B NH2 1 
ATOM   2833 N N   . GLY B 2 7   ? 13.230 -13.803 -20.770 1.00 83.48  ? 22  GLY B N   1 
ATOM   2834 C CA  . GLY B 2 7   ? 12.433 -13.079 -21.780 1.00 83.52  ? 22  GLY B CA  1 
ATOM   2835 C C   . GLY B 2 7   ? 11.547 -14.018 -22.591 1.00 90.10  ? 22  GLY B C   1 
ATOM   2836 O O   . GLY B 2 7   ? 10.388 -13.639 -22.852 1.00 88.77  ? 22  GLY B O   1 
ATOM   2837 N N   . SER B 2 8   ? 12.074 -15.187 -22.993 1.00 87.62  ? 23  SER B N   1 
ATOM   2838 C CA  . SER B 2 8   ? 11.359 -16.235 -23.780 1.00 84.40  ? 23  SER B CA  1 
ATOM   2839 C C   . SER B 2 8   ? 11.670 -17.645 -23.235 1.00 78.11  ? 23  SER B C   1 
ATOM   2840 O O   . SER B 2 8   ? 12.778 -17.861 -22.701 1.00 72.01  ? 23  SER B O   1 
ATOM   2841 C CB  . SER B 2 8   ? 11.691 -16.111 -25.257 1.00 82.30  ? 23  SER B CB  1 
ATOM   2842 O OG  . SER B 2 8   ? 11.351 -17.296 -25.963 1.00 80.59  ? 23  SER B OG  1 
ATOM   2843 N N   . ASN B 2 9   ? 10.717 -18.576 -23.349 1.00 68.80  ? 24  ASN B N   1 
ATOM   2844 C CA  . ASN B 2 9   ? 10.865 -19.977 -22.864 1.00 67.84  ? 24  ASN B CA  1 
ATOM   2845 C C   . ASN B 2 9   ? 10.439 -20.961 -23.971 1.00 59.56  ? 24  ASN B C   1 
ATOM   2846 O O   . ASN B 2 9   ? 9.930  -22.063 -23.652 1.00 56.92  ? 24  ASN B O   1 
ATOM   2847 C CB  . ASN B 2 9   ? 10.135 -20.188 -21.532 1.00 74.49  ? 24  ASN B CB  1 
ATOM   2848 C CG  . ASN B 2 9   ? 8.628  -20.034 -21.606 1.00 76.74  ? 24  ASN B CG  1 
ATOM   2849 O OD1 . ASN B 2 9   ? 8.044  -19.940 -22.686 1.00 78.06  ? 24  ASN B OD1 1 
ATOM   2850 N ND2 . ASN B 2 9   ? 7.983  -20.001 -20.450 1.00 80.61  ? 24  ASN B ND2 1 
ATOM   2851 N N   . VAL B 2 10  ? 10.659 -20.600 -25.239 1.00 49.29  ? 25  VAL B N   1 
ATOM   2852 C CA  . VAL B 2 10  ? 10.701 -21.583 -26.363 1.00 42.81  ? 25  VAL B CA  1 
ATOM   2853 C C   . VAL B 2 10  ? 11.922 -22.493 -26.148 1.00 33.22  ? 25  VAL B C   1 
ATOM   2854 O O   . VAL B 2 10  ? 13.014 -21.999 -25.880 1.00 33.76  ? 25  VAL B O   1 
ATOM   2855 C CB  . VAL B 2 10  ? 10.705 -20.885 -27.738 1.00 43.30  ? 25  VAL B CB  1 
ATOM   2856 C CG1 . VAL B 2 10  ? 10.985 -21.862 -28.875 1.00 41.68  ? 25  VAL B CG1 1 
ATOM   2857 C CG2 . VAL B 2 10  ? 9.381  -20.151 -27.971 1.00 43.37  ? 25  VAL B CG2 1 
ATOM   2858 N N   . ALA B 2 11  ? 11.711 -23.793 -26.179 1.00 30.07  ? 26  ALA B N   1 
ATOM   2859 C CA  . ALA B 2 11  ? 12.763 -24.816 -26.044 1.00 35.55  ? 26  ALA B CA  1 
ATOM   2860 C C   . ALA B 2 11  ? 13.857 -24.601 -27.114 1.00 38.00  ? 26  ALA B C   1 
ATOM   2861 O O   . ALA B 2 11  ? 13.496 -24.411 -28.277 1.00 36.91  ? 26  ALA B O   1 
ATOM   2862 C CB  . ALA B 2 11  ? 12.131 -26.182 -26.169 1.00 35.83  ? 26  ALA B CB  1 
ATOM   2863 N N   . LEU B 2 12  ? 15.139 -24.667 -26.729 1.00 34.23  ? 27  LEU B N   1 
ATOM   2864 C CA  . LEU B 2 12  ? 16.279 -24.774 -27.674 1.00 34.13  ? 27  LEU B CA  1 
ATOM   2865 C C   . LEU B 2 12  ? 16.264 -26.171 -28.306 1.00 33.31  ? 27  LEU B C   1 
ATOM   2866 O O   . LEU B 2 12  ? 15.831 -27.115 -27.642 1.00 33.27  ? 27  LEU B O   1 
ATOM   2867 C CB  . LEU B 2 12  ? 17.611 -24.565 -26.938 1.00 34.58  ? 27  LEU B CB  1 
ATOM   2868 C CG  . LEU B 2 12  ? 17.810 -23.246 -26.194 1.00 33.60  ? 27  LEU B CG  1 
ATOM   2869 C CD1 . LEU B 2 12  ? 19.033 -23.298 -25.293 1.00 31.10  ? 27  LEU B CD1 1 
ATOM   2870 C CD2 . LEU B 2 12  ? 17.917 -22.095 -27.172 1.00 34.89  ? 27  LEU B CD2 1 
ATOM   2871 N N   . MET B 2 13  ? 16.813 -26.309 -29.510 1.00 31.44  ? 28  MET B N   1 
ATOM   2872 C CA  . MET B 2 13  ? 17.026 -27.616 -30.184 1.00 34.45  ? 28  MET B CA  1 
ATOM   2873 C C   . MET B 2 13  ? 18.431 -28.103 -29.825 1.00 33.95  ? 28  MET B C   1 
ATOM   2874 O O   . MET B 2 13  ? 19.353 -27.280 -29.875 1.00 37.52  ? 28  MET B O   1 
ATOM   2875 C CB  . MET B 2 13  ? 16.879 -27.454 -31.699 1.00 39.02  ? 28  MET B CB  1 
ATOM   2876 C CG  . MET B 2 13  ? 15.440 -27.156 -32.155 1.00 42.37  ? 28  MET B CG  1 
ATOM   2877 S SD  . MET B 2 13  ? 15.308 -26.600 -33.900 1.00 43.76  ? 28  MET B SD  1 
ATOM   2878 C CE  . MET B 2 13  ? 15.490 -24.823 -33.763 1.00 47.19  ? 28  MET B CE  1 
ATOM   2879 N N   . LEU B 2 14  ? 18.577 -29.360 -29.421 1.00 34.51  ? 29  LEU B N   1 
ATOM   2880 C CA  . LEU B 2 14  ? 19.810 -29.910 -28.795 1.00 39.41  ? 29  LEU B CA  1 
ATOM   2881 C C   . LEU B 2 14  ? 20.682 -30.632 -29.825 1.00 43.26  ? 29  LEU B C   1 
ATOM   2882 O O   . LEU B 2 14  ? 21.926 -30.703 -29.604 1.00 47.40  ? 29  LEU B O   1 
ATOM   2883 C CB  . LEU B 2 14  ? 19.452 -30.853 -27.639 1.00 41.49  ? 29  LEU B CB  1 
ATOM   2884 C CG  . LEU B 2 14  ? 18.745 -30.192 -26.451 1.00 45.86  ? 29  LEU B CG  1 
ATOM   2885 C CD1 . LEU B 2 14  ? 18.421 -31.220 -25.381 1.00 44.93  ? 29  LEU B CD1 1 
ATOM   2886 C CD2 . LEU B 2 14  ? 19.562 -29.040 -25.859 1.00 45.30  ? 29  LEU B CD2 1 
ATOM   2887 N N   . ASP B 2 15  ? 20.091 -31.165 -30.891 1.00 41.05  ? 30  ASP B N   1 
ATOM   2888 C CA  . ASP B 2 15  ? 20.883 -31.860 -31.937 1.00 49.22  ? 30  ASP B CA  1 
ATOM   2889 C C   . ASP B 2 15  ? 20.194 -31.626 -33.268 1.00 42.45  ? 30  ASP B C   1 
ATOM   2890 O O   . ASP B 2 15  ? 18.986 -31.396 -33.298 1.00 56.66  ? 30  ASP B O   1 
ATOM   2891 C CB  . ASP B 2 15  ? 21.134 -33.337 -31.612 1.00 64.80  ? 30  ASP B CB  1 
ATOM   2892 C CG  . ASP B 2 15  ? 19.894 -34.200 -31.414 1.00 75.63  ? 30  ASP B CG  1 
ATOM   2893 O OD1 . ASP B 2 15  ? 18.762 -33.661 -31.506 1.00 81.76  ? 30  ASP B OD1 1 
ATOM   2894 O OD2 . ASP B 2 15  ? 20.071 -35.417 -31.163 1.00 83.38  ? 30  ASP B OD2 1 
ATOM   2895 N N   . CYS B 2 16  ? 20.984 -31.567 -34.314 1.00 39.11  ? 31  CYS B N   1 
ATOM   2896 C CA  . CYS B 2 16  ? 20.543 -31.046 -35.630 1.00 39.00  ? 31  CYS B CA  1 
ATOM   2897 C C   . CYS B 2 16  ? 21.540 -31.574 -36.650 1.00 39.97  ? 31  CYS B C   1 
ATOM   2898 O O   . CYS B 2 16  ? 22.517 -32.107 -36.138 1.00 39.27  ? 31  CYS B O   1 
ATOM   2899 C CB  . CYS B 2 16  ? 20.469 -29.516 -35.632 1.00 34.23  ? 31  CYS B CB  1 
ATOM   2900 S SG  . CYS B 2 16  ? 22.043 -28.730 -35.206 1.00 29.01  ? 31  CYS B SG  1 
ATOM   2901 O OXT . CYS B 2 16  ? 21.364 -31.484 -37.866 1.00 56.45  ? 31  CYS B OXT 1 
HETATM 2902 O O   . HOH C 3 .   ? 25.237 -23.346 -0.815  1.00 34.05  ? 401 HOH A O   1 
HETATM 2903 O O   . HOH C 3 .   ? 21.403 -35.022 -18.853 1.00 46.25  ? 402 HOH A O   1 
HETATM 2904 O O   . HOH C 3 .   ? 45.935 -16.450 -12.405 1.00 38.85  ? 403 HOH A O   1 
HETATM 2905 O O   . HOH C 3 .   ? 36.867 -48.746 -11.397 1.00 37.05  ? 404 HOH A O   1 
HETATM 2906 O O   . HOH C 3 .   ? 32.934 -32.663 -21.406 1.00 36.78  ? 405 HOH A O   1 
HETATM 2907 O O   . HOH C 3 .   ? 38.535 -38.846 3.691   1.00 35.66  ? 406 HOH A O   1 
HETATM 2908 O O   . HOH C 3 .   ? 39.190 -32.001 -4.627  1.00 40.34  ? 407 HOH A O   1 
HETATM 2909 O O   . HOH C 3 .   ? 32.771 -56.279 -11.200 1.00 34.90  ? 408 HOH A O   1 
HETATM 2910 O O   . HOH C 3 .   ? 33.299 -53.558 -11.757 1.00 37.36  ? 409 HOH A O   1 
HETATM 2911 O O   . HOH C 3 .   ? 33.882 -23.322 -29.887 1.00 42.38  ? 410 HOH A O   1 
HETATM 2912 O O   . HOH C 3 .   ? 37.592 -18.061 -2.673  1.00 43.98  ? 411 HOH A O   1 
HETATM 2913 O O   . HOH C 3 .   ? 25.290 -34.419 -11.436 1.00 40.53  ? 412 HOH A O   1 
HETATM 2914 O O   . HOH C 3 .   ? 35.005 -35.308 -12.453 1.00 34.71  ? 413 HOH A O   1 
HETATM 2915 O O   . HOH C 3 .   ? 16.174 -22.533 -31.257 1.00 43.46  ? 414 HOH A O   1 
HETATM 2916 O O   . HOH C 3 .   ? 31.017 -52.378 -0.026  1.00 26.97  ? 415 HOH A O   1 
HETATM 2917 O O   . HOH C 3 .   ? 36.808 -54.349 -13.519 1.00 49.97  ? 416 HOH A O   1 
HETATM 2918 O O   . HOH C 3 .   ? 21.963 -30.929 -19.484 1.00 43.38  ? 417 HOH A O   1 
HETATM 2919 O O   . HOH C 3 .   ? 39.717 -39.761 -11.227 1.00 41.86  ? 418 HOH A O   1 
HETATM 2920 O O   . HOH C 3 .   ? 23.397 -7.818  -11.971 1.00 28.18  ? 419 HOH A O   1 
HETATM 2921 O O   . HOH C 3 .   ? 30.076 -39.638 -14.138 1.00 37.29  ? 420 HOH A O   1 
HETATM 2922 O O   . HOH C 3 .   ? 38.079 -48.326 4.479   1.00 29.88  ? 421 HOH A O   1 
HETATM 2923 O O   . HOH C 3 .   ? 32.329 -52.133 4.041   1.00 40.66  ? 422 HOH A O   1 
HETATM 2924 O O   . HOH C 3 .   ? 41.801 -30.847 -4.556  1.00 29.19  ? 423 HOH A O   1 
HETATM 2925 O O   . HOH C 3 .   ? 19.512 -38.703 1.094   1.00 50.42  ? 424 HOH A O   1 
HETATM 2926 O O   . HOH C 3 .   ? 39.332 -17.890 -27.156 1.00 22.85  ? 425 HOH A O   1 
HETATM 2927 O O   . HOH C 3 .   ? 27.287 -33.476 -5.037  1.00 25.60  ? 426 HOH A O   1 
HETATM 2928 O O   . HOH C 3 .   ? 39.620 -28.511 -10.297 1.00 39.25  ? 427 HOH A O   1 
HETATM 2929 O O   . HOH C 3 .   ? 14.697 -22.713 -23.687 1.00 36.59  ? 428 HOH A O   1 
HETATM 2930 O O   . HOH C 3 .   ? 47.373 -54.725 -1.195  1.00 49.84  ? 429 HOH A O   1 
HETATM 2931 O O   . HOH C 3 .   ? 34.300 -46.810 6.024   1.00 37.67  ? 430 HOH A O   1 
HETATM 2932 O O   . HOH C 3 .   ? 60.738 -11.871 -28.821 1.00 45.74  ? 431 HOH A O   1 
HETATM 2933 O O   . HOH C 3 .   ? 23.647 -30.012 -10.318 1.00 40.69  ? 432 HOH A O   1 
HETATM 2934 O O   . HOH C 3 .   ? 41.197 -23.769 -23.403 1.00 26.54  ? 433 HOH A O   1 
HETATM 2935 O O   . HOH C 3 .   ? 30.311 -7.391  -32.883 1.00 40.76  ? 434 HOH A O   1 
HETATM 2936 O O   . HOH C 3 .   ? 28.762 -29.050 0.353   1.00 36.48  ? 435 HOH A O   1 
HETATM 2937 O O   . HOH C 3 .   ? 39.474 -25.533 -0.303  1.00 32.86  ? 436 HOH A O   1 
HETATM 2938 O O   . HOH C 3 .   ? 25.708 -35.537 -4.053  1.00 47.15  ? 437 HOH A O   1 
HETATM 2939 O O   . HOH C 3 .   ? 33.925 -0.379  -20.525 0.56 36.69  ? 438 HOH A O   1 
HETATM 2940 O O   . HOH C 3 .   ? 15.458 -15.200 -26.145 1.00 34.31  ? 439 HOH A O   1 
HETATM 2941 O O   . HOH C 3 .   ? 24.806 -14.397 -29.909 1.00 48.27  ? 440 HOH A O   1 
HETATM 2942 O O   . HOH C 3 .   ? 31.934 -29.742 -28.170 1.00 28.33  ? 441 HOH A O   1 
HETATM 2943 O O   . HOH C 3 .   ? 50.580 -43.809 -12.093 1.00 29.63  ? 442 HOH A O   1 
HETATM 2944 O O   . HOH C 3 .   ? 46.394 -37.773 -12.769 1.00 51.19  ? 443 HOH A O   1 
HETATM 2945 O O   . HOH C 3 .   ? 30.801 -1.030  -23.463 1.00 40.15  ? 444 HOH A O   1 
HETATM 2946 O O   . HOH C 3 .   ? 33.005 -16.844 -4.687  1.00 23.81  ? 445 HOH A O   1 
HETATM 2947 O O   . HOH C 3 .   ? 28.700 -35.609 -15.997 1.00 38.44  ? 446 HOH A O   1 
HETATM 2948 O O   . HOH C 3 .   ? 38.255 -5.933  -13.994 1.00 29.31  ? 447 HOH A O   1 
HETATM 2949 O O   . HOH C 3 .   ? 28.161 -26.514 -0.217  1.00 26.85  ? 448 HOH A O   1 
HETATM 2950 O O   . HOH C 3 .   ? 50.815 -37.027 -2.220  1.00 31.11  ? 449 HOH A O   1 
HETATM 2951 O O   . HOH C 3 .   ? 19.580 -52.863 -19.222 1.00 41.00  ? 450 HOH A O   1 
HETATM 2952 O O   . HOH C 3 .   ? 20.630 -5.045  -18.289 1.00 42.21  ? 451 HOH A O   1 
HETATM 2953 O O   . HOH C 3 .   ? 12.301 -29.831 -26.495 1.00 41.51  ? 452 HOH A O   1 
HETATM 2954 O O   . HOH C 3 .   ? 54.362 -41.304 4.274   1.00 28.55  ? 453 HOH A O   1 
HETATM 2955 O O   . HOH C 3 .   ? 43.579 -10.672 -30.746 1.00 28.86  ? 454 HOH A O   1 
HETATM 2956 O O   . HOH C 3 .   ? 48.308 -32.075 -4.848  1.00 45.46  ? 455 HOH A O   1 
HETATM 2957 O O   . HOH C 3 .   ? 25.951 -12.526 -5.508  1.00 38.03  ? 456 HOH A O   1 
HETATM 2958 O O   . HOH C 3 .   ? 47.046 -22.566 -28.871 1.00 41.84  ? 457 HOH A O   1 
HETATM 2959 O O   . HOH C 3 .   ? 44.712 -33.642 6.018   1.00 43.31  ? 458 HOH A O   1 
HETATM 2960 O O   . HOH C 3 .   ? 33.235 -36.139 1.629   1.00 28.25  ? 459 HOH A O   1 
HETATM 2961 O O   . HOH C 3 .   ? 24.095 -24.355 -3.735  1.00 29.85  ? 460 HOH A O   1 
HETATM 2962 O O   . HOH C 3 .   ? 35.547 -15.532 -8.459  1.00 21.78  ? 461 HOH A O   1 
HETATM 2963 O O   . HOH C 3 .   ? 30.566 -23.309 -30.973 1.00 51.00  ? 462 HOH A O   1 
HETATM 2964 O O   . HOH C 3 .   ? 41.655 -5.911  -21.052 1.00 31.88  ? 463 HOH A O   1 
HETATM 2965 O O   . HOH C 3 .   ? 31.179 -32.204 -24.441 1.00 38.76  ? 464 HOH A O   1 
HETATM 2966 O O   . HOH C 3 .   ? 17.896 -22.923 -35.930 1.00 24.05  ? 465 HOH A O   1 
HETATM 2967 O O   . HOH C 3 .   ? 34.252 -34.035 0.188   1.00 27.38  ? 466 HOH A O   1 
HETATM 2968 O O   . HOH C 3 .   ? 28.972 -30.505 -29.193 1.00 39.22  ? 467 HOH A O   1 
HETATM 2969 O O   . HOH C 3 .   ? 36.918 -34.460 -14.529 1.00 39.92  ? 468 HOH A O   1 
HETATM 2970 O O   . HOH C 3 .   ? 41.610 -23.006 -18.676 1.00 35.64  ? 469 HOH A O   1 
HETATM 2971 O O   . HOH C 3 .   ? 28.407 -53.593 -3.165  1.00 33.80  ? 470 HOH A O   1 
HETATM 2972 O O   . HOH C 3 .   ? 27.354 -45.950 -0.316  1.00 37.93  ? 471 HOH A O   1 
HETATM 2973 O O   . HOH C 3 .   ? 39.154 -22.235 -16.606 1.00 21.77  ? 472 HOH A O   1 
HETATM 2974 O O   . HOH C 3 .   ? 48.467 -15.945 -36.329 1.00 47.75  ? 473 HOH A O   1 
HETATM 2975 O O   . HOH C 3 .   ? 33.457 -37.993 -16.050 1.00 47.11  ? 474 HOH A O   1 
HETATM 2976 O O   . HOH C 3 .   ? 25.757 -19.246 -6.548  1.00 23.84  ? 475 HOH A O   1 
HETATM 2977 O O   . HOH C 3 .   ? 48.637 -4.347  -13.210 1.00 54.92  ? 476 HOH A O   1 
HETATM 2978 O O   . HOH C 3 .   ? 32.378 -46.932 -22.660 1.00 45.13  ? 477 HOH A O   1 
HETATM 2979 O O   . HOH C 3 .   ? 29.233 -18.620 -30.820 1.00 25.86  ? 478 HOH A O   1 
HETATM 2980 O O   . HOH C 3 .   ? 34.800 0.774   -34.516 1.00 49.71  ? 479 HOH A O   1 
HETATM 2981 O O   . HOH C 3 .   ? 34.348 -33.097 -12.557 1.00 38.53  ? 480 HOH A O   1 
HETATM 2982 O O   . HOH C 3 .   ? 23.408 -47.777 -6.312  1.00 29.81  ? 481 HOH A O   1 
HETATM 2983 O O   . HOH C 3 .   ? 26.057 -29.784 -7.550  1.00 23.27  ? 482 HOH A O   1 
HETATM 2984 O O   . HOH C 3 .   ? 34.698 -51.070 -21.513 1.00 70.81  ? 483 HOH A O   1 
HETATM 2985 O O   . HOH C 3 .   ? 18.444 -53.912 -6.786  1.00 35.60  ? 484 HOH A O   1 
HETATM 2986 O O   . HOH C 3 .   ? 35.014 -13.313 -30.436 1.00 36.58  ? 485 HOH A O   1 
HETATM 2987 O O   . HOH C 3 .   ? 22.419 -2.158  -22.815 1.00 43.37  ? 486 HOH A O   1 
HETATM 2988 O O   . HOH C 3 .   ? 41.195 -42.074 -11.177 1.00 36.26  ? 487 HOH A O   1 
HETATM 2989 O O   . HOH C 3 .   ? 38.653 -30.819 -17.410 1.00 46.27  ? 488 HOH A O   1 
HETATM 2990 O O   . HOH C 3 .   ? 26.920 -17.535 -30.819 1.00 29.76  ? 489 HOH A O   1 
HETATM 2991 O O   . HOH C 3 .   ? 24.921 -8.515  -27.449 1.00 36.95  ? 490 HOH A O   1 
HETATM 2992 O O   . HOH C 3 .   ? 47.041 -37.630 -8.274  1.00 28.03  ? 491 HOH A O   1 
HETATM 2993 O O   . HOH C 3 .   ? 21.218 -31.715 -22.574 1.00 56.81  ? 492 HOH A O   1 
HETATM 2994 O O   . HOH C 3 .   ? 16.574 -30.721 -22.591 1.00 39.12  ? 493 HOH A O   1 
HETATM 2995 O O   . HOH C 3 .   ? 23.234 -33.206 -28.265 1.00 43.07  ? 494 HOH A O   1 
HETATM 2996 O O   . HOH C 3 .   ? 26.035 -54.068 -16.000 1.00 40.76  ? 495 HOH A O   1 
HETATM 2997 O O   . HOH C 3 .   ? 38.299 -46.670 7.626   1.00 37.07  ? 496 HOH A O   1 
HETATM 2998 O O   . HOH C 3 .   ? 42.173 -20.316 -17.692 1.00 29.03  ? 497 HOH A O   1 
HETATM 2999 O O   . HOH C 3 .   ? 36.573 -17.866 -27.565 1.00 21.65  ? 498 HOH A O   1 
HETATM 3000 O O   . HOH C 3 .   ? 12.235 -22.869 -21.309 1.00 52.41  ? 499 HOH A O   1 
HETATM 3001 O O   . HOH C 3 .   ? 29.177 -24.989 -32.398 1.00 42.20  ? 500 HOH A O   1 
HETATM 3002 O O   . HOH C 3 .   ? 29.457 -38.037 3.125   1.00 45.45  ? 501 HOH A O   1 
HETATM 3003 O O   . HOH C 3 .   ? 40.053 -23.846 -20.601 1.00 33.21  ? 502 HOH A O   1 
HETATM 3004 O O   . HOH C 3 .   ? 32.895 -44.387 5.808   1.00 34.04  ? 503 HOH A O   1 
HETATM 3005 O O   . HOH C 3 .   ? 42.722 -17.643 -23.933 1.00 29.20  ? 504 HOH A O   1 
HETATM 3006 O O   . HOH C 3 .   ? 32.330 -8.254  -33.830 1.00 39.47  ? 505 HOH A O   1 
HETATM 3007 O O   . HOH C 3 .   ? 22.397 -15.996 -2.146  1.00 32.59  ? 506 HOH A O   1 
HETATM 3008 O O   . HOH C 3 .   ? 27.167 -10.089 -5.774  1.00 39.65  ? 507 HOH A O   1 
HETATM 3009 O O   . HOH C 3 .   ? 20.632 -39.903 -7.383  1.00 40.49  ? 508 HOH A O   1 
HETATM 3010 O O   . HOH C 3 .   ? 42.182 -36.748 4.204   1.00 36.77  ? 509 HOH A O   1 
HETATM 3011 O O   . HOH C 3 .   ? 36.977 -23.761 1.661   1.00 37.84  ? 510 HOH A O   1 
HETATM 3012 O O   . HOH C 3 .   ? 24.757 -60.608 -14.878 1.00 42.82  ? 511 HOH A O   1 
HETATM 3013 O O   . HOH C 3 .   ? 25.041 -46.627 -3.874  1.00 42.40  ? 512 HOH A O   1 
HETATM 3014 O O   . HOH C 3 .   ? 40.963 -26.392 -6.705  1.00 41.34  ? 513 HOH A O   1 
HETATM 3015 O O   . HOH C 3 .   ? 36.756 -5.913  -9.831  1.00 51.47  ? 514 HOH A O   1 
HETATM 3016 O O   . HOH C 3 .   ? 18.849 -41.003 -5.243  1.00 49.33  ? 515 HOH A O   1 
HETATM 3017 O O   . HOH C 3 .   ? 50.520 -39.758 -1.269  1.00 28.65  ? 516 HOH A O   1 
HETATM 3018 O O   . HOH C 3 .   ? 35.862 -31.431 -22.750 1.00 45.61  ? 517 HOH A O   1 
HETATM 3019 O O   . HOH C 3 .   ? 33.621 -40.283 5.320   1.00 38.34  ? 518 HOH A O   1 
HETATM 3020 O O   . HOH C 3 .   ? 41.920 -26.673 2.453   1.00 25.96  ? 519 HOH A O   1 
HETATM 3021 O O   . HOH C 3 .   ? 27.353 -47.190 -2.695  1.00 28.07  ? 520 HOH A O   1 
HETATM 3022 O O   . HOH C 3 .   ? 43.842 -40.913 8.801   1.00 40.50  ? 521 HOH A O   1 
HETATM 3023 O O   . HOH C 3 .   ? 35.518 -30.568 3.504   1.00 27.17  ? 522 HOH A O   1 
HETATM 3024 O O   . HOH C 3 .   ? 33.712 -31.869 1.947   1.00 32.18  ? 523 HOH A O   1 
HETATM 3025 O O   . HOH C 3 .   ? 35.677 -16.554 -3.901  1.00 30.02  ? 524 HOH A O   1 
HETATM 3026 O O   . HOH C 3 .   ? 19.718 -22.456 -13.430 1.00 40.00  ? 525 HOH A O   1 
HETATM 3027 O O   . HOH C 3 .   ? 43.086 -50.582 -9.191  1.00 44.05  ? 526 HOH A O   1 
HETATM 3028 O O   . HOH C 3 .   ? 41.817 -0.223  -30.410 1.00 51.65  ? 527 HOH A O   1 
HETATM 3029 O O   . HOH C 3 .   ? 18.437 -31.124 -17.862 1.00 45.50  ? 528 HOH A O   1 
HETATM 3030 O O   . HOH C 3 .   ? 27.620 -36.030 -1.530  1.00 42.95  ? 529 HOH A O   1 
HETATM 3031 O O   . HOH C 3 .   ? 34.341 -10.554 -4.707  1.00 38.49  ? 530 HOH A O   1 
HETATM 3032 O O   . HOH C 3 .   ? 35.065 -24.945 -28.439 1.00 34.57  ? 531 HOH A O   1 
HETATM 3033 O O   . HOH C 3 .   ? 24.199 -30.129 -31.737 1.00 47.73  ? 532 HOH A O   1 
HETATM 3034 O O   . HOH C 3 .   ? 37.431 -41.651 5.923   1.00 36.89  ? 533 HOH A O   1 
HETATM 3035 O O   . HOH C 3 .   ? 49.536 -50.092 -0.427  1.00 30.17  ? 534 HOH A O   1 
HETATM 3036 O O   . HOH C 3 .   ? 29.575 -33.655 1.252   1.00 43.91  ? 535 HOH A O   1 
HETATM 3037 O O   . HOH C 3 .   ? 41.733 -44.183 -12.710 1.00 46.44  ? 536 HOH A O   1 
HETATM 3038 O O   . HOH C 3 .   ? 23.181 -40.823 -24.797 1.00 53.59  ? 537 HOH A O   1 
HETATM 3039 O O   . HOH C 3 .   ? 17.434 -11.127 -26.595 1.00 39.80  ? 538 HOH A O   1 
HETATM 3040 O O   . HOH C 3 .   ? 38.451 -15.419 -35.001 1.00 36.44  ? 539 HOH A O   1 
HETATM 3041 O O   . HOH C 3 .   ? 41.017 -33.356 3.449   1.00 30.82  ? 540 HOH A O   1 
HETATM 3042 O O   . HOH C 3 .   ? 25.018 -18.355 0.548   1.00 41.80  ? 541 HOH A O   1 
HETATM 3043 O O   . HOH C 3 .   ? 48.142 -12.534 -14.300 1.00 47.91  ? 542 HOH A O   1 
HETATM 3044 O O   . HOH C 3 .   ? 51.663 -46.272 6.563   1.00 32.70  ? 543 HOH A O   1 
HETATM 3045 O O   . HOH C 3 .   ? 52.388 -48.240 -8.770  1.00 37.98  ? 544 HOH A O   1 
HETATM 3046 O O   . HOH C 3 .   ? 20.408 -9.385  -0.156  1.00 38.46  ? 545 HOH A O   1 
HETATM 3047 O O   . HOH C 3 .   ? 36.146 5.412   -28.544 1.00 37.94  ? 546 HOH A O   1 
HETATM 3048 O O   . HOH C 3 .   ? 35.378 -53.840 -7.082  1.00 38.93  ? 547 HOH A O   1 
HETATM 3049 O O   . HOH C 3 .   ? 57.264 -39.388 -0.731  1.00 42.82  ? 548 HOH A O   1 
HETATM 3050 O O   . HOH C 3 .   ? 38.856 -40.286 -18.082 1.00 52.39  ? 549 HOH A O   1 
HETATM 3051 O O   . HOH C 3 .   ? 36.943 -22.282 -33.988 1.00 42.39  ? 550 HOH A O   1 
HETATM 3052 O O   . HOH C 3 .   ? 27.511 -37.547 0.710   1.00 41.02  ? 551 HOH A O   1 
HETATM 3053 O O   . HOH C 3 .   ? 25.551 -10.294 -29.962 1.00 41.69  ? 552 HOH A O   1 
HETATM 3054 O O   . HOH C 3 .   ? 53.689 -43.328 0.498   1.00 28.16  ? 553 HOH A O   1 
HETATM 3055 O O   . HOH C 3 .   ? 52.773 -45.677 -7.047  1.00 27.69  ? 554 HOH A O   1 
HETATM 3056 O O   . HOH C 3 .   ? 33.747 -14.779 -6.681  1.00 24.20  ? 555 HOH A O   1 
HETATM 3057 O O   . HOH C 3 .   ? 28.414 -9.046  -31.326 1.00 40.73  ? 556 HOH A O   1 
HETATM 3058 O O   . HOH C 3 .   ? 24.161 -58.780 -6.783  1.00 40.61  ? 557 HOH A O   1 
HETATM 3059 O O   . HOH C 3 .   ? 19.193 -10.820 -29.682 1.00 42.65  ? 558 HOH A O   1 
HETATM 3060 O O   . HOH C 3 .   ? 28.154 -37.041 -19.614 1.00 45.55  ? 559 HOH A O   1 
HETATM 3061 O O   . HOH C 3 .   ? 35.145 -26.495 -26.138 1.00 29.19  ? 560 HOH A O   1 
HETATM 3062 O O   . HOH C 3 .   ? 20.849 -47.489 -5.760  1.00 30.31  ? 561 HOH A O   1 
HETATM 3063 O O   . HOH C 3 .   ? 28.407 -49.296 -3.306  1.00 26.61  ? 562 HOH A O   1 
HETATM 3064 O O   . HOH C 3 .   ? 18.953 -51.460 -7.826  1.00 31.89  ? 563 HOH A O   1 
HETATM 3065 O O   . HOH C 3 .   ? 48.991 -52.042 -2.313  1.00 42.45  ? 564 HOH A O   1 
HETATM 3066 O O   . HOH C 3 .   ? 52.339 -47.119 -1.944  1.00 23.81  ? 565 HOH A O   1 
HETATM 3067 O O   . HOH C 3 .   ? 23.560 -27.320 -1.114  1.00 45.79  ? 566 HOH A O   1 
HETATM 3068 O O   . HOH C 3 .   ? 36.938 -28.638 -26.705 1.00 45.37  ? 567 HOH A O   1 
HETATM 3069 O O   . HOH C 3 .   ? 29.310 -30.355 2.717   1.00 42.43  ? 568 HOH A O   1 
HETATM 3070 O O   . HOH C 3 .   ? 54.826 -21.175 -11.765 1.00 52.11  ? 569 HOH A O   1 
HETATM 3071 O O   . HOH C 3 .   ? 24.658 -14.454 -32.458 1.00 33.72  ? 570 HOH A O   1 
HETATM 3072 O O   . HOH C 3 .   ? 48.993 -35.393 -6.329  1.00 36.96  ? 571 HOH A O   1 
HETATM 3073 O O   . HOH C 3 .   ? 39.028 -15.660 -2.940  1.00 39.31  ? 572 HOH A O   1 
HETATM 3074 O O   . HOH C 3 .   ? 53.650 -34.286 0.638   1.00 58.60  ? 573 HOH A O   1 
HETATM 3075 O O   . HOH C 3 .   ? 22.039 -28.651 -17.856 1.00 43.12  ? 574 HOH A O   1 
HETATM 3076 O O   . HOH C 3 .   ? 44.959 -30.649 8.156   1.00 46.33  ? 575 HOH A O   1 
HETATM 3077 O O   . HOH C 3 .   ? 47.664 -33.093 5.760   1.00 45.56  ? 576 HOH A O   1 
HETATM 3078 O O   . HOH C 3 .   ? 52.506 -43.216 -8.303  1.00 29.49  ? 577 HOH A O   1 
HETATM 3079 O O   . HOH C 3 .   ? 22.097 -23.954 -5.891  1.00 39.80  ? 578 HOH A O   1 
HETATM 3080 O O   . HOH C 3 .   ? 49.395 -51.270 2.271   1.00 32.48  ? 579 HOH A O   1 
HETATM 3081 O O   . HOH C 3 .   ? 52.294 -34.987 -1.066  1.00 45.56  ? 580 HOH A O   1 
HETATM 3082 O O   . HOH C 3 .   ? 32.287 -37.633 -13.172 1.00 47.56  ? 581 HOH A O   1 
HETATM 3083 O O   . HOH C 3 .   ? 23.513 -33.003 -10.830 1.00 37.94  ? 582 HOH A O   1 
HETATM 3084 O O   . HOH C 3 .   ? 41.766 -24.723 0.125   1.00 40.09  ? 583 HOH A O   1 
HETATM 3085 O O   . HOH C 3 .   ? 53.714 -43.570 3.233   1.00 27.12  ? 584 HOH A O   1 
HETATM 3086 O O   . HOH C 3 .   ? 36.778 -9.223  -3.687  1.00 40.78  ? 585 HOH A O   1 
HETATM 3087 O O   . HOH C 3 .   ? 40.940 -11.138 -7.877  1.00 42.00  ? 586 HOH A O   1 
HETATM 3088 O O   . HOH C 3 .   ? 21.500 -28.522 -6.075  1.00 48.92  ? 587 HOH A O   1 
HETATM 3089 O O   . HOH C 3 .   ? 44.873 -55.373 -3.928  1.00 50.65  ? 588 HOH A O   1 
HETATM 3090 O O   . HOH C 3 .   ? 25.268 -50.504 -0.934  1.00 41.92  ? 589 HOH A O   1 
HETATM 3091 O O   . HOH C 3 .   ? 26.540 -50.999 -3.386  1.00 33.66  ? 590 HOH A O   1 
HETATM 3092 O O   . HOH C 3 .   ? 23.885 -12.273 -29.660 1.00 44.81  ? 591 HOH A O   1 
HETATM 3093 O O   . HOH C 3 .   ? 34.838 -13.182 -4.582  1.00 35.62  ? 592 HOH A O   1 
HETATM 3094 O O   . HOH C 3 .   ? 47.191 -36.304 -10.849 1.00 39.67  ? 593 HOH A O   1 
HETATM 3095 O O   . HOH C 3 .   ? 44.687 -26.756 2.382   1.00 46.09  ? 594 HOH A O   1 
HETATM 3096 O O   . HOH C 3 .   ? 36.335 -11.586 -32.011 1.00 31.56  ? 595 HOH A O   1 
HETATM 3097 O O   . HOH C 3 .   ? 26.938 -53.364 12.209  1.00 40.67  ? 596 HOH A O   1 
HETATM 3098 O O   . HOH C 3 .   ? 21.906 -5.771  -11.007 1.00 37.68  ? 597 HOH A O   1 
HETATM 3099 O O   . HOH C 3 .   ? 36.271 -21.243 3.046   1.00 46.47  ? 598 HOH A O   1 
HETATM 3100 O O   . HOH C 3 .   ? 35.811 -8.877  -37.667 1.00 36.70  ? 599 HOH A O   1 
HETATM 3101 O O   . HOH C 3 .   ? 9.696  -29.052 -27.060 1.00 33.17  ? 600 HOH A O   1 
HETATM 3102 O O   . HOH C 3 .   ? 16.411 -48.081 3.588   1.00 43.57  ? 601 HOH A O   1 
HETATM 3103 O O   . HOH C 3 .   ? 31.649 -15.417 -2.683  1.00 34.75  ? 602 HOH A O   1 
HETATM 3104 O O   . HOH C 3 .   ? 57.691 -23.082 -33.800 1.00 44.98  ? 603 HOH A O   1 
HETATM 3105 O O   . HOH C 3 .   ? 53.731 -41.112 -7.108  1.00 44.05  ? 604 HOH A O   1 
HETATM 3106 O O   . HOH C 3 .   ? 52.295 -49.709 -1.052  1.00 30.01  ? 605 HOH A O   1 
HETATM 3107 O O   . HOH C 3 .   ? 54.399 -45.703 -0.994  1.00 24.34  ? 606 HOH A O   1 
HETATM 3108 O O   . HOH C 3 .   ? 53.708 -46.695 -4.571  1.00 35.95  ? 607 HOH A O   1 
HETATM 3109 O O   . HOH C 3 .   ? 18.855 -49.330 -6.330  1.00 27.90  ? 608 HOH A O   1 
HETATM 3110 O O   . HOH C 3 .   ? 55.990 -42.581 -3.340  1.00 34.66  ? 609 HOH A O   1 
HETATM 3111 O O   . HOH C 3 .   ? 52.880 -51.109 -5.746  1.00 29.97  ? 610 HOH A O   1 
HETATM 3112 O O   . HOH C 3 .   ? 14.798 -25.598 -37.487 1.00 27.67  ? 611 HOH A O   1 
HETATM 3113 O O   . HOH D 3 .   ? 14.408 -20.193 -26.854 1.00 43.80  ? 201 HOH B O   1 
HETATM 3114 O O   . HOH D 3 .   ? 16.892 -16.985 -21.549 1.00 46.20  ? 202 HOH B O   1 
HETATM 3115 O O   . HOH D 3 .   ? 13.378 -24.669 -30.888 1.00 45.82  ? 203 HOH B O   1 
HETATM 3116 O O   . HOH D 3 .   ? 23.541 -30.779 -39.322 1.00 43.74  ? 204 HOH B O   1 
HETATM 3117 O O   . HOH D 3 .   ? 13.716 -28.721 -28.510 1.00 25.47  ? 205 HOH B O   1 
HETATM 3118 O O   . HOH D 3 .   ? 15.230 -17.011 -23.967 1.00 48.64  ? 206 HOH B O   1 
HETATM 3119 O O   . HOH D 3 .   ? 8.248  -17.208 -23.942 1.00 50.38  ? 207 HOH B O   1 
HETATM 3120 O O   . HOH D 3 .   ? 9.086  -24.921 -26.964 1.00 28.73  ? 208 HOH B O   1 
HETATM 3121 O O   . HOH D 3 .   ? 20.930 -31.741 -41.471 1.00 46.03  ? 209 HOH B O   1 
HETATM 3122 O O   . HOH D 3 .   ? 11.903 -27.332 -29.847 1.00 31.43  ? 210 HOH B O   1 
# 
