data_8YP4
# 
_entry.id   8YP4 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YP4         pdb_00008yp4 10.2210/pdb8yp4/pdb 
WWPDB D_1300046093 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YP4 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              kinotk@omu.ac.jp 
_pdbx_contact_author.name_first         Takayoshi 
_pdbx_contact_author.name_last          Kinoshita 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2850-5409 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yumura, S.'    1 0009-0002-9226-5526 
'Kinoshita, T.' 2 0000-0003-2850-5409 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Bioorg.Med.Chem.Lett. 
_citation.journal_id_ASTM           BMCLE8 
_citation.journal_id_CSD            1127 
_citation.journal_id_ISSN           1464-3405 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            112 
_citation.language                  ? 
_citation.page_first                129914 
_citation.page_last                 129914 
_citation.title                     
;Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.bmcl.2024.129914 
_citation.pdbx_database_id_PubMed   39111728 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yumura, S.'    1 ? 
primary 'Kitagawa, D.'  2 ? 
primary 'Moritsugu, K.' 3 ? 
primary 'Nakayama, A.'  4 ? 
primary 'Shinada, T.'   5 ? 
primary 'Sawa, M.'      6 ? 
primary 'Kinoshita, T.' 7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Dual specificity mitogen-activated protein kinase kinase 1' 40835.996 2   2.7.12.2 'T286A, T292A, S298A' ? ? 
2 non-polymer syn 
;(4~{S},9~{S},10~{S},12~{E})-16-methoxy-4-methyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(18),12,14,16-tetraene-2,8-dione
;
364.390   2   ?        ?                     ? ? 
3 non-polymer syn GLYCEROL 92.094    1   ?        ?                     ? ? 
4 water       nat water 18.015    137 ?        ?                     ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII
RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK
PSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE
LMFGCQVEGDAAEAPPRPRAPGRPLASYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL
KQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTAAALEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII
RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK
PSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE
LMFGCQVEGDAAEAPPRPRAPGRPLASYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL
KQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTAAALEHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(4~{S},9~{S},10~{S},12~{E})-16-methoxy-4-methyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(18),12,14,16-tetraene-2,8-dione
;
WNT 
3 GLYCEROL GOL 
4 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLN n 
1 3   LYS n 
1 4   LYS n 
1 5   LEU n 
1 6   GLU n 
1 7   GLU n 
1 8   LEU n 
1 9   GLU n 
1 10  LEU n 
1 11  ASP n 
1 12  GLU n 
1 13  GLN n 
1 14  GLN n 
1 15  ARG n 
1 16  LYS n 
1 17  ARG n 
1 18  LEU n 
1 19  GLU n 
1 20  ALA n 
1 21  PHE n 
1 22  LEU n 
1 23  THR n 
1 24  GLN n 
1 25  LYS n 
1 26  GLN n 
1 27  LYS n 
1 28  VAL n 
1 29  GLY n 
1 30  GLU n 
1 31  LEU n 
1 32  LYS n 
1 33  ASP n 
1 34  ASP n 
1 35  ASP n 
1 36  PHE n 
1 37  GLU n 
1 38  LYS n 
1 39  ILE n 
1 40  SER n 
1 41  GLU n 
1 42  LEU n 
1 43  GLY n 
1 44  ALA n 
1 45  GLY n 
1 46  ASN n 
1 47  GLY n 
1 48  GLY n 
1 49  VAL n 
1 50  VAL n 
1 51  PHE n 
1 52  LYS n 
1 53  VAL n 
1 54  SER n 
1 55  HIS n 
1 56  LYS n 
1 57  PRO n 
1 58  SER n 
1 59  GLY n 
1 60  LEU n 
1 61  VAL n 
1 62  MET n 
1 63  ALA n 
1 64  ARG n 
1 65  LYS n 
1 66  LEU n 
1 67  ILE n 
1 68  HIS n 
1 69  LEU n 
1 70  GLU n 
1 71  ILE n 
1 72  LYS n 
1 73  PRO n 
1 74  ALA n 
1 75  ILE n 
1 76  ARG n 
1 77  ASN n 
1 78  GLN n 
1 79  ILE n 
1 80  ILE n 
1 81  ARG n 
1 82  GLU n 
1 83  LEU n 
1 84  GLN n 
1 85  VAL n 
1 86  LEU n 
1 87  HIS n 
1 88  GLU n 
1 89  CYS n 
1 90  ASN n 
1 91  SER n 
1 92  PRO n 
1 93  TYR n 
1 94  ILE n 
1 95  VAL n 
1 96  GLY n 
1 97  PHE n 
1 98  TYR n 
1 99  GLY n 
1 100 ALA n 
1 101 PHE n 
1 102 TYR n 
1 103 SER n 
1 104 ASP n 
1 105 GLY n 
1 106 GLU n 
1 107 ILE n 
1 108 SER n 
1 109 ILE n 
1 110 CYS n 
1 111 MET n 
1 112 GLU n 
1 113 HIS n 
1 114 MET n 
1 115 ASP n 
1 116 GLY n 
1 117 GLY n 
1 118 SER n 
1 119 LEU n 
1 120 ASP n 
1 121 GLN n 
1 122 VAL n 
1 123 LEU n 
1 124 LYS n 
1 125 LYS n 
1 126 ALA n 
1 127 GLY n 
1 128 ARG n 
1 129 ILE n 
1 130 PRO n 
1 131 GLU n 
1 132 GLN n 
1 133 ILE n 
1 134 LEU n 
1 135 GLY n 
1 136 LYS n 
1 137 VAL n 
1 138 SER n 
1 139 ILE n 
1 140 ALA n 
1 141 VAL n 
1 142 ILE n 
1 143 LYS n 
1 144 GLY n 
1 145 LEU n 
1 146 THR n 
1 147 TYR n 
1 148 LEU n 
1 149 ARG n 
1 150 GLU n 
1 151 LYS n 
1 152 HIS n 
1 153 LYS n 
1 154 ILE n 
1 155 MET n 
1 156 HIS n 
1 157 ARG n 
1 158 ASP n 
1 159 VAL n 
1 160 LYS n 
1 161 PRO n 
1 162 SER n 
1 163 ASN n 
1 164 ILE n 
1 165 LEU n 
1 166 VAL n 
1 167 ASN n 
1 168 SER n 
1 169 ARG n 
1 170 GLY n 
1 171 GLU n 
1 172 ILE n 
1 173 LYS n 
1 174 LEU n 
1 175 CYS n 
1 176 ASP n 
1 177 PHE n 
1 178 GLY n 
1 179 VAL n 
1 180 SER n 
1 181 GLY n 
1 182 GLN n 
1 183 LEU n 
1 184 ILE n 
1 185 ASP n 
1 186 SER n 
1 187 MET n 
1 188 ALA n 
1 189 ASN n 
1 190 SER n 
1 191 PHE n 
1 192 VAL n 
1 193 GLY n 
1 194 THR n 
1 195 ARG n 
1 196 SER n 
1 197 TYR n 
1 198 MET n 
1 199 SER n 
1 200 PRO n 
1 201 GLU n 
1 202 ARG n 
1 203 LEU n 
1 204 GLN n 
1 205 GLY n 
1 206 THR n 
1 207 HIS n 
1 208 TYR n 
1 209 SER n 
1 210 VAL n 
1 211 GLN n 
1 212 SER n 
1 213 ASP n 
1 214 ILE n 
1 215 TRP n 
1 216 SER n 
1 217 MET n 
1 218 GLY n 
1 219 LEU n 
1 220 SER n 
1 221 LEU n 
1 222 VAL n 
1 223 GLU n 
1 224 MET n 
1 225 ALA n 
1 226 VAL n 
1 227 GLY n 
1 228 ARG n 
1 229 TYR n 
1 230 PRO n 
1 231 ILE n 
1 232 PRO n 
1 233 PRO n 
1 234 PRO n 
1 235 ASP n 
1 236 ALA n 
1 237 LYS n 
1 238 GLU n 
1 239 LEU n 
1 240 GLU n 
1 241 LEU n 
1 242 MET n 
1 243 PHE n 
1 244 GLY n 
1 245 CYS n 
1 246 GLN n 
1 247 VAL n 
1 248 GLU n 
1 249 GLY n 
1 250 ASP n 
1 251 ALA n 
1 252 ALA n 
1 253 GLU n 
1 254 ALA n 
1 255 PRO n 
1 256 PRO n 
1 257 ARG n 
1 258 PRO n 
1 259 ARG n 
1 260 ALA n 
1 261 PRO n 
1 262 GLY n 
1 263 ARG n 
1 264 PRO n 
1 265 LEU n 
1 266 ALA n 
1 267 SER n 
1 268 TYR n 
1 269 GLY n 
1 270 MET n 
1 271 ASP n 
1 272 SER n 
1 273 ARG n 
1 274 PRO n 
1 275 PRO n 
1 276 MET n 
1 277 ALA n 
1 278 ILE n 
1 279 PHE n 
1 280 GLU n 
1 281 LEU n 
1 282 LEU n 
1 283 ASP n 
1 284 TYR n 
1 285 ILE n 
1 286 VAL n 
1 287 ASN n 
1 288 GLU n 
1 289 PRO n 
1 290 PRO n 
1 291 PRO n 
1 292 LYS n 
1 293 LEU n 
1 294 PRO n 
1 295 SER n 
1 296 GLY n 
1 297 VAL n 
1 298 PHE n 
1 299 SER n 
1 300 LEU n 
1 301 GLU n 
1 302 PHE n 
1 303 GLN n 
1 304 ASP n 
1 305 PHE n 
1 306 VAL n 
1 307 ASN n 
1 308 LYS n 
1 309 CYS n 
1 310 LEU n 
1 311 ILE n 
1 312 LYS n 
1 313 ASN n 
1 314 PRO n 
1 315 ALA n 
1 316 GLU n 
1 317 ARG n 
1 318 ALA n 
1 319 ASP n 
1 320 LEU n 
1 321 LYS n 
1 322 GLN n 
1 323 LEU n 
1 324 MET n 
1 325 VAL n 
1 326 HIS n 
1 327 ALA n 
1 328 PHE n 
1 329 ILE n 
1 330 LYS n 
1 331 ARG n 
1 332 SER n 
1 333 ASP n 
1 334 ALA n 
1 335 GLU n 
1 336 GLU n 
1 337 VAL n 
1 338 ASP n 
1 339 PHE n 
1 340 ALA n 
1 341 GLY n 
1 342 TRP n 
1 343 LEU n 
1 344 CYS n 
1 345 SER n 
1 346 THR n 
1 347 ILE n 
1 348 GLY n 
1 349 LEU n 
1 350 ASN n 
1 351 GLN n 
1 352 PRO n 
1 353 SER n 
1 354 THR n 
1 355 ALA n 
1 356 ALA n 
1 357 ALA n 
1 358 LEU n 
1 359 GLU n 
1 360 HIS n 
1 361 HIS n 
1 362 HIS n 
1 363 HIS n 
1 364 HIS n 
1 365 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   365 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'MAP2K1, MEK1, PRKMK1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ?                               'C5 H11 N O2'    117.146 
WNT non-polymer         . 
;(4~{S},9~{S},10~{S},12~{E})-16-methoxy-4-methyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(18),12,14,16-tetraene-2,8-dione
;
?                               'C19 H24 O7'     364.390 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   33  ?   ?   ?   A . n 
A 1 2   GLN 2   34  34  GLN GLN A . n 
A 1 3   LYS 3   35  35  LYS LYS A . n 
A 1 4   LYS 4   36  36  LYS LYS A . n 
A 1 5   LEU 5   37  37  LEU LEU A . n 
A 1 6   GLU 6   38  38  GLU GLU A . n 
A 1 7   GLU 7   39  39  GLU GLU A . n 
A 1 8   LEU 8   40  40  LEU LEU A . n 
A 1 9   GLU 9   41  41  GLU GLU A . n 
A 1 10  LEU 10  42  42  LEU LEU A . n 
A 1 11  ASP 11  43  43  ASP ASP A . n 
A 1 12  GLU 12  44  44  GLU GLU A . n 
A 1 13  GLN 13  45  45  GLN GLN A . n 
A 1 14  GLN 14  46  46  GLN GLN A . n 
A 1 15  ARG 15  47  47  ARG ARG A . n 
A 1 16  LYS 16  48  48  LYS LYS A . n 
A 1 17  ARG 17  49  49  ARG ARG A . n 
A 1 18  LEU 18  50  50  LEU LEU A . n 
A 1 19  GLU 19  51  51  GLU GLU A . n 
A 1 20  ALA 20  52  52  ALA ALA A . n 
A 1 21  PHE 21  53  53  PHE PHE A . n 
A 1 22  LEU 22  54  54  LEU LEU A . n 
A 1 23  THR 23  55  55  THR THR A . n 
A 1 24  GLN 24  56  56  GLN GLN A . n 
A 1 25  LYS 25  57  57  LYS LYS A . n 
A 1 26  GLN 26  58  58  GLN GLN A . n 
A 1 27  LYS 27  59  59  LYS LYS A . n 
A 1 28  VAL 28  60  60  VAL VAL A . n 
A 1 29  GLY 29  61  61  GLY GLY A . n 
A 1 30  GLU 30  62  62  GLU GLU A . n 
A 1 31  LEU 31  63  63  LEU LEU A . n 
A 1 32  LYS 32  64  64  LYS LYS A . n 
A 1 33  ASP 33  65  65  ASP ASP A . n 
A 1 34  ASP 34  66  66  ASP ASP A . n 
A 1 35  ASP 35  67  67  ASP ASP A . n 
A 1 36  PHE 36  68  68  PHE PHE A . n 
A 1 37  GLU 37  69  69  GLU GLU A . n 
A 1 38  LYS 38  70  70  LYS LYS A . n 
A 1 39  ILE 39  71  71  ILE ILE A . n 
A 1 40  SER 40  72  72  SER SER A . n 
A 1 41  GLU 41  73  73  GLU GLU A . n 
A 1 42  LEU 42  74  74  LEU LEU A . n 
A 1 43  GLY 43  75  75  GLY GLY A . n 
A 1 44  ALA 44  76  76  ALA ALA A . n 
A 1 45  GLY 45  77  77  GLY GLY A . n 
A 1 46  ASN 46  78  78  ASN ASN A . n 
A 1 47  GLY 47  79  79  GLY GLY A . n 
A 1 48  GLY 48  80  80  GLY GLY A . n 
A 1 49  VAL 49  81  81  VAL VAL A . n 
A 1 50  VAL 50  82  82  VAL VAL A . n 
A 1 51  PHE 51  83  83  PHE PHE A . n 
A 1 52  LYS 52  84  84  LYS LYS A . n 
A 1 53  VAL 53  85  85  VAL VAL A . n 
A 1 54  SER 54  86  86  SER SER A . n 
A 1 55  HIS 55  87  87  HIS HIS A . n 
A 1 56  LYS 56  88  88  LYS LYS A . n 
A 1 57  PRO 57  89  89  PRO PRO A . n 
A 1 58  SER 58  90  90  SER SER A . n 
A 1 59  GLY 59  91  91  GLY GLY A . n 
A 1 60  LEU 60  92  92  LEU LEU A . n 
A 1 61  VAL 61  93  93  VAL VAL A . n 
A 1 62  MET 62  94  94  MET MET A . n 
A 1 63  ALA 63  95  95  ALA ALA A . n 
A 1 64  ARG 64  96  96  ARG ARG A . n 
A 1 65  LYS 65  97  97  LYS LYS A . n 
A 1 66  LEU 66  98  98  LEU LEU A . n 
A 1 67  ILE 67  99  99  ILE ILE A . n 
A 1 68  HIS 68  100 100 HIS HIS A . n 
A 1 69  LEU 69  101 101 LEU LEU A . n 
A 1 70  GLU 70  102 102 GLU GLU A . n 
A 1 71  ILE 71  103 103 ILE ILE A . n 
A 1 72  LYS 72  104 104 LYS LYS A . n 
A 1 73  PRO 73  105 105 PRO PRO A . n 
A 1 74  ALA 74  106 106 ALA ALA A . n 
A 1 75  ILE 75  107 107 ILE ILE A . n 
A 1 76  ARG 76  108 108 ARG ARG A . n 
A 1 77  ASN 77  109 109 ASN ASN A . n 
A 1 78  GLN 78  110 110 GLN GLN A . n 
A 1 79  ILE 79  111 111 ILE ILE A . n 
A 1 80  ILE 80  112 112 ILE ILE A . n 
A 1 81  ARG 81  113 113 ARG ARG A . n 
A 1 82  GLU 82  114 114 GLU GLU A . n 
A 1 83  LEU 83  115 115 LEU LEU A . n 
A 1 84  GLN 84  116 116 GLN GLN A . n 
A 1 85  VAL 85  117 117 VAL VAL A . n 
A 1 86  LEU 86  118 118 LEU LEU A . n 
A 1 87  HIS 87  119 119 HIS HIS A . n 
A 1 88  GLU 88  120 ?   ?   ?   A . n 
A 1 89  CYS 89  121 121 CYS CYS A . n 
A 1 90  ASN 90  122 122 ASN ASN A . n 
A 1 91  SER 91  123 123 SER SER A . n 
A 1 92  PRO 92  124 124 PRO PRO A . n 
A 1 93  TYR 93  125 125 TYR TYR A . n 
A 1 94  ILE 94  126 126 ILE ILE A . n 
A 1 95  VAL 95  127 127 VAL VAL A . n 
A 1 96  GLY 96  128 128 GLY GLY A . n 
A 1 97  PHE 97  129 129 PHE PHE A . n 
A 1 98  TYR 98  130 130 TYR TYR A . n 
A 1 99  GLY 99  131 131 GLY GLY A . n 
A 1 100 ALA 100 132 132 ALA ALA A . n 
A 1 101 PHE 101 133 133 PHE PHE A . n 
A 1 102 TYR 102 134 134 TYR TYR A . n 
A 1 103 SER 103 135 135 SER SER A . n 
A 1 104 ASP 104 136 136 ASP ASP A . n 
A 1 105 GLY 105 137 137 GLY GLY A . n 
A 1 106 GLU 106 138 138 GLU GLU A . n 
A 1 107 ILE 107 139 139 ILE ILE A . n 
A 1 108 SER 108 140 140 SER SER A . n 
A 1 109 ILE 109 141 141 ILE ILE A . n 
A 1 110 CYS 110 142 142 CYS CYS A . n 
A 1 111 MET 111 143 143 MET MET A . n 
A 1 112 GLU 112 144 144 GLU GLU A . n 
A 1 113 HIS 113 145 145 HIS HIS A . n 
A 1 114 MET 114 146 146 MET MET A . n 
A 1 115 ASP 115 147 147 ASP ASP A . n 
A 1 116 GLY 116 148 148 GLY GLY A . n 
A 1 117 GLY 117 149 149 GLY GLY A . n 
A 1 118 SER 118 150 150 SER SER A . n 
A 1 119 LEU 119 151 151 LEU LEU A . n 
A 1 120 ASP 120 152 152 ASP ASP A . n 
A 1 121 GLN 121 153 153 GLN GLN A . n 
A 1 122 VAL 122 154 154 VAL VAL A . n 
A 1 123 LEU 123 155 155 LEU LEU A . n 
A 1 124 LYS 124 156 156 LYS LYS A . n 
A 1 125 LYS 125 157 157 LYS LYS A . n 
A 1 126 ALA 126 158 158 ALA ALA A . n 
A 1 127 GLY 127 159 159 GLY GLY A . n 
A 1 128 ARG 128 160 160 ARG ARG A . n 
A 1 129 ILE 129 161 161 ILE ILE A . n 
A 1 130 PRO 130 162 162 PRO PRO A . n 
A 1 131 GLU 131 163 163 GLU GLU A . n 
A 1 132 GLN 132 164 164 GLN GLN A . n 
A 1 133 ILE 133 165 165 ILE ILE A . n 
A 1 134 LEU 134 166 166 LEU LEU A . n 
A 1 135 GLY 135 167 167 GLY GLY A . n 
A 1 136 LYS 136 168 168 LYS LYS A . n 
A 1 137 VAL 137 169 169 VAL VAL A . n 
A 1 138 SER 138 170 170 SER SER A . n 
A 1 139 ILE 139 171 171 ILE ILE A . n 
A 1 140 ALA 140 172 172 ALA ALA A . n 
A 1 141 VAL 141 173 173 VAL VAL A . n 
A 1 142 ILE 142 174 174 ILE ILE A . n 
A 1 143 LYS 143 175 175 LYS LYS A . n 
A 1 144 GLY 144 176 176 GLY GLY A . n 
A 1 145 LEU 145 177 177 LEU LEU A . n 
A 1 146 THR 146 178 178 THR THR A . n 
A 1 147 TYR 147 179 179 TYR TYR A . n 
A 1 148 LEU 148 180 180 LEU LEU A . n 
A 1 149 ARG 149 181 181 ARG ARG A . n 
A 1 150 GLU 150 182 182 GLU GLU A . n 
A 1 151 LYS 151 183 183 LYS LYS A . n 
A 1 152 HIS 152 184 184 HIS HIS A . n 
A 1 153 LYS 153 185 185 LYS LYS A . n 
A 1 154 ILE 154 186 186 ILE ILE A . n 
A 1 155 MET 155 187 187 MET MET A . n 
A 1 156 HIS 156 188 188 HIS HIS A . n 
A 1 157 ARG 157 189 189 ARG ARG A . n 
A 1 158 ASP 158 190 190 ASP ASP A . n 
A 1 159 VAL 159 191 191 VAL VAL A . n 
A 1 160 LYS 160 192 192 LYS LYS A . n 
A 1 161 PRO 161 193 193 PRO PRO A . n 
A 1 162 SER 162 194 194 SER SER A . n 
A 1 163 ASN 163 195 195 ASN ASN A . n 
A 1 164 ILE 164 196 196 ILE ILE A . n 
A 1 165 LEU 165 197 197 LEU LEU A . n 
A 1 166 VAL 166 198 198 VAL VAL A . n 
A 1 167 ASN 167 199 199 ASN ASN A . n 
A 1 168 SER 168 200 200 SER SER A . n 
A 1 169 ARG 169 201 201 ARG ARG A . n 
A 1 170 GLY 170 202 202 GLY GLY A . n 
A 1 171 GLU 171 203 203 GLU GLU A . n 
A 1 172 ILE 172 204 204 ILE ILE A . n 
A 1 173 LYS 173 205 205 LYS LYS A . n 
A 1 174 LEU 174 206 206 LEU LEU A . n 
A 1 175 CYS 175 207 207 CYS CYS A . n 
A 1 176 ASP 176 208 208 ASP ASP A . n 
A 1 177 PHE 177 209 209 PHE PHE A . n 
A 1 178 GLY 178 210 210 GLY GLY A . n 
A 1 179 VAL 179 211 211 VAL VAL A . n 
A 1 180 SER 180 212 212 SER SER A . n 
A 1 181 GLY 181 213 213 GLY GLY A . n 
A 1 182 GLN 182 214 214 GLN GLN A . n 
A 1 183 LEU 183 215 ?   ?   ?   A . n 
A 1 184 ILE 184 216 ?   ?   ?   A . n 
A 1 185 ASP 185 217 ?   ?   ?   A . n 
A 1 186 SER 186 218 ?   ?   ?   A . n 
A 1 187 MET 187 219 ?   ?   ?   A . n 
A 1 188 ALA 188 220 ?   ?   ?   A . n 
A 1 189 ASN 189 221 ?   ?   ?   A . n 
A 1 190 SER 190 222 ?   ?   ?   A . n 
A 1 191 PHE 191 223 ?   ?   ?   A . n 
A 1 192 VAL 192 224 224 VAL VAL A . n 
A 1 193 GLY 193 225 225 GLY GLY A . n 
A 1 194 THR 194 226 226 THR THR A . n 
A 1 195 ARG 195 227 227 ARG ARG A . n 
A 1 196 SER 196 228 228 SER SER A . n 
A 1 197 TYR 197 229 229 TYR TYR A . n 
A 1 198 MET 198 230 230 MET MET A . n 
A 1 199 SER 199 231 231 SER SER A . n 
A 1 200 PRO 200 232 232 PRO PRO A . n 
A 1 201 GLU 201 233 233 GLU GLU A . n 
A 1 202 ARG 202 234 234 ARG ARG A . n 
A 1 203 LEU 203 235 235 LEU LEU A . n 
A 1 204 GLN 204 236 236 GLN GLN A . n 
A 1 205 GLY 205 237 ?   ?   ?   A . n 
A 1 206 THR 206 238 ?   ?   ?   A . n 
A 1 207 HIS 207 239 ?   ?   ?   A . n 
A 1 208 TYR 208 240 240 TYR TYR A . n 
A 1 209 SER 209 241 241 SER SER A . n 
A 1 210 VAL 210 242 242 VAL VAL A . n 
A 1 211 GLN 211 243 243 GLN GLN A . n 
A 1 212 SER 212 244 244 SER SER A . n 
A 1 213 ASP 213 245 245 ASP ASP A . n 
A 1 214 ILE 214 246 246 ILE ILE A . n 
A 1 215 TRP 215 247 247 TRP TRP A . n 
A 1 216 SER 216 248 248 SER SER A . n 
A 1 217 MET 217 249 249 MET MET A . n 
A 1 218 GLY 218 250 250 GLY GLY A . n 
A 1 219 LEU 219 251 251 LEU LEU A . n 
A 1 220 SER 220 252 252 SER SER A . n 
A 1 221 LEU 221 253 253 LEU LEU A . n 
A 1 222 VAL 222 254 254 VAL VAL A . n 
A 1 223 GLU 223 255 255 GLU GLU A . n 
A 1 224 MET 224 256 256 MET MET A . n 
A 1 225 ALA 225 257 257 ALA ALA A . n 
A 1 226 VAL 226 258 258 VAL VAL A . n 
A 1 227 GLY 227 259 259 GLY GLY A . n 
A 1 228 ARG 228 260 260 ARG ARG A . n 
A 1 229 TYR 229 261 261 TYR TYR A . n 
A 1 230 PRO 230 262 262 PRO PRO A . n 
A 1 231 ILE 231 263 263 ILE ILE A . n 
A 1 232 PRO 232 264 264 PRO PRO A . n 
A 1 233 PRO 233 265 265 PRO PRO A . n 
A 1 234 PRO 234 266 266 PRO PRO A . n 
A 1 235 ASP 235 267 267 ASP ASP A . n 
A 1 236 ALA 236 268 268 ALA ALA A . n 
A 1 237 LYS 237 269 269 LYS LYS A . n 
A 1 238 GLU 238 270 270 GLU GLU A . n 
A 1 239 LEU 239 271 271 LEU LEU A . n 
A 1 240 GLU 240 272 272 GLU GLU A . n 
A 1 241 LEU 241 273 273 LEU LEU A . n 
A 1 242 MET 242 274 274 MET MET A . n 
A 1 243 PHE 243 275 275 PHE PHE A . n 
A 1 244 GLY 244 276 ?   ?   ?   A . n 
A 1 245 CYS 245 277 ?   ?   ?   A . n 
A 1 246 GLN 246 278 ?   ?   ?   A . n 
A 1 247 VAL 247 279 ?   ?   ?   A . n 
A 1 248 GLU 248 280 ?   ?   ?   A . n 
A 1 249 GLY 249 281 ?   ?   ?   A . n 
A 1 250 ASP 250 282 ?   ?   ?   A . n 
A 1 251 ALA 251 283 ?   ?   ?   A . n 
A 1 252 ALA 252 284 ?   ?   ?   A . n 
A 1 253 GLU 253 285 ?   ?   ?   A . n 
A 1 254 ALA 254 286 ?   ?   ?   A . n 
A 1 255 PRO 255 287 ?   ?   ?   A . n 
A 1 256 PRO 256 288 ?   ?   ?   A . n 
A 1 257 ARG 257 289 ?   ?   ?   A . n 
A 1 258 PRO 258 290 ?   ?   ?   A . n 
A 1 259 ARG 259 291 ?   ?   ?   A . n 
A 1 260 ALA 260 292 ?   ?   ?   A . n 
A 1 261 PRO 261 293 ?   ?   ?   A . n 
A 1 262 GLY 262 294 ?   ?   ?   A . n 
A 1 263 ARG 263 295 ?   ?   ?   A . n 
A 1 264 PRO 264 296 ?   ?   ?   A . n 
A 1 265 LEU 265 297 ?   ?   ?   A . n 
A 1 266 ALA 266 298 ?   ?   ?   A . n 
A 1 267 SER 267 299 ?   ?   ?   A . n 
A 1 268 TYR 268 300 ?   ?   ?   A . n 
A 1 269 GLY 269 301 ?   ?   ?   A . n 
A 1 270 MET 270 302 ?   ?   ?   A . n 
A 1 271 ASP 271 303 ?   ?   ?   A . n 
A 1 272 SER 272 304 ?   ?   ?   A . n 
A 1 273 ARG 273 305 ?   ?   ?   A . n 
A 1 274 PRO 274 306 ?   ?   ?   A . n 
A 1 275 PRO 275 307 ?   ?   ?   A . n 
A 1 276 MET 276 308 ?   ?   ?   A . n 
A 1 277 ALA 277 309 309 ALA ALA A . n 
A 1 278 ILE 278 310 310 ILE ILE A . n 
A 1 279 PHE 279 311 311 PHE PHE A . n 
A 1 280 GLU 280 312 312 GLU GLU A . n 
A 1 281 LEU 281 313 313 LEU LEU A . n 
A 1 282 LEU 282 314 314 LEU LEU A . n 
A 1 283 ASP 283 315 315 ASP ASP A . n 
A 1 284 TYR 284 316 316 TYR TYR A . n 
A 1 285 ILE 285 317 317 ILE ILE A . n 
A 1 286 VAL 286 318 318 VAL VAL A . n 
A 1 287 ASN 287 319 319 ASN ASN A . n 
A 1 288 GLU 288 320 320 GLU GLU A . n 
A 1 289 PRO 289 321 321 PRO PRO A . n 
A 1 290 PRO 290 322 322 PRO PRO A . n 
A 1 291 PRO 291 323 323 PRO PRO A . n 
A 1 292 LYS 292 324 324 LYS LYS A . n 
A 1 293 LEU 293 325 325 LEU LEU A . n 
A 1 294 PRO 294 326 326 PRO PRO A . n 
A 1 295 SER 295 327 327 SER SER A . n 
A 1 296 GLY 296 328 328 GLY GLY A . n 
A 1 297 VAL 297 329 329 VAL VAL A . n 
A 1 298 PHE 298 330 330 PHE PHE A . n 
A 1 299 SER 299 331 331 SER SER A . n 
A 1 300 LEU 300 332 332 LEU LEU A . n 
A 1 301 GLU 301 333 333 GLU GLU A . n 
A 1 302 PHE 302 334 334 PHE PHE A . n 
A 1 303 GLN 303 335 335 GLN GLN A . n 
A 1 304 ASP 304 336 336 ASP ASP A . n 
A 1 305 PHE 305 337 337 PHE PHE A . n 
A 1 306 VAL 306 338 338 VAL VAL A . n 
A 1 307 ASN 307 339 339 ASN ASN A . n 
A 1 308 LYS 308 340 340 LYS LYS A . n 
A 1 309 CYS 309 341 341 CYS CYS A . n 
A 1 310 LEU 310 342 342 LEU LEU A . n 
A 1 311 ILE 311 343 343 ILE ILE A . n 
A 1 312 LYS 312 344 344 LYS LYS A . n 
A 1 313 ASN 313 345 345 ASN ASN A . n 
A 1 314 PRO 314 346 346 PRO PRO A . n 
A 1 315 ALA 315 347 347 ALA ALA A . n 
A 1 316 GLU 316 348 348 GLU GLU A . n 
A 1 317 ARG 317 349 349 ARG ARG A . n 
A 1 318 ALA 318 350 350 ALA ALA A . n 
A 1 319 ASP 319 351 351 ASP ASP A . n 
A 1 320 LEU 320 352 352 LEU LEU A . n 
A 1 321 LYS 321 353 353 LYS LYS A . n 
A 1 322 GLN 322 354 354 GLN GLN A . n 
A 1 323 LEU 323 355 355 LEU LEU A . n 
A 1 324 MET 324 356 356 MET MET A . n 
A 1 325 VAL 325 357 357 VAL VAL A . n 
A 1 326 HIS 326 358 358 HIS HIS A . n 
A 1 327 ALA 327 359 359 ALA ALA A . n 
A 1 328 PHE 328 360 360 PHE PHE A . n 
A 1 329 ILE 329 361 361 ILE ILE A . n 
A 1 330 LYS 330 362 362 LYS LYS A . n 
A 1 331 ARG 331 363 363 ARG ARG A . n 
A 1 332 SER 332 364 364 SER SER A . n 
A 1 333 ASP 333 365 365 ASP ASP A . n 
A 1 334 ALA 334 366 366 ALA ALA A . n 
A 1 335 GLU 335 367 367 GLU GLU A . n 
A 1 336 GLU 336 368 368 GLU GLU A . n 
A 1 337 VAL 337 369 369 VAL VAL A . n 
A 1 338 ASP 338 370 370 ASP ASP A . n 
A 1 339 PHE 339 371 371 PHE PHE A . n 
A 1 340 ALA 340 372 372 ALA ALA A . n 
A 1 341 GLY 341 373 373 GLY GLY A . n 
A 1 342 TRP 342 374 374 TRP TRP A . n 
A 1 343 LEU 343 375 375 LEU LEU A . n 
A 1 344 CYS 344 376 376 CYS CYS A . n 
A 1 345 SER 345 377 377 SER SER A . n 
A 1 346 THR 346 378 378 THR THR A . n 
A 1 347 ILE 347 379 379 ILE ILE A . n 
A 1 348 GLY 348 380 380 GLY GLY A . n 
A 1 349 LEU 349 381 381 LEU LEU A . n 
A 1 350 ASN 350 382 382 ASN ASN A . n 
A 1 351 GLN 351 383 383 GLN GLN A . n 
A 1 352 PRO 352 384 384 PRO PRO A . n 
A 1 353 SER 353 385 ?   ?   ?   A . n 
A 1 354 THR 354 386 ?   ?   ?   A . n 
A 1 355 ALA 355 387 ?   ?   ?   A . n 
A 1 356 ALA 356 388 ?   ?   ?   A . n 
A 1 357 ALA 357 389 ?   ?   ?   A . n 
A 1 358 LEU 358 390 ?   ?   ?   A . n 
A 1 359 GLU 359 391 ?   ?   ?   A . n 
A 1 360 HIS 360 392 ?   ?   ?   A . n 
A 1 361 HIS 361 393 ?   ?   ?   A . n 
A 1 362 HIS 362 394 ?   ?   ?   A . n 
A 1 363 HIS 363 395 ?   ?   ?   A . n 
A 1 364 HIS 364 396 ?   ?   ?   A . n 
A 1 365 HIS 365 397 ?   ?   ?   A . n 
B 1 1   MET 1   33  ?   ?   ?   B . n 
B 1 2   GLN 2   34  ?   ?   ?   B . n 
B 1 3   LYS 3   35  ?   ?   ?   B . n 
B 1 4   LYS 4   36  ?   ?   ?   B . n 
B 1 5   LEU 5   37  ?   ?   ?   B . n 
B 1 6   GLU 6   38  ?   ?   ?   B . n 
B 1 7   GLU 7   39  ?   ?   ?   B . n 
B 1 8   LEU 8   40  ?   ?   ?   B . n 
B 1 9   GLU 9   41  ?   ?   ?   B . n 
B 1 10  LEU 10  42  ?   ?   ?   B . n 
B 1 11  ASP 11  43  43  ASP ASP B . n 
B 1 12  GLU 12  44  44  GLU GLU B . n 
B 1 13  GLN 13  45  45  GLN GLN B . n 
B 1 14  GLN 14  46  46  GLN GLN B . n 
B 1 15  ARG 15  47  47  ARG ARG B . n 
B 1 16  LYS 16  48  48  LYS LYS B . n 
B 1 17  ARG 17  49  49  ARG ARG B . n 
B 1 18  LEU 18  50  50  LEU LEU B . n 
B 1 19  GLU 19  51  51  GLU GLU B . n 
B 1 20  ALA 20  52  52  ALA ALA B . n 
B 1 21  PHE 21  53  53  PHE PHE B . n 
B 1 22  LEU 22  54  54  LEU LEU B . n 
B 1 23  THR 23  55  55  THR THR B . n 
B 1 24  GLN 24  56  56  GLN GLN B . n 
B 1 25  LYS 25  57  57  LYS LYS B . n 
B 1 26  GLN 26  58  58  GLN GLN B . n 
B 1 27  LYS 27  59  59  LYS LYS B . n 
B 1 28  VAL 28  60  60  VAL VAL B . n 
B 1 29  GLY 29  61  61  GLY GLY B . n 
B 1 30  GLU 30  62  62  GLU GLU B . n 
B 1 31  LEU 31  63  63  LEU LEU B . n 
B 1 32  LYS 32  64  64  LYS LYS B . n 
B 1 33  ASP 33  65  65  ASP ASP B . n 
B 1 34  ASP 34  66  66  ASP ASP B . n 
B 1 35  ASP 35  67  67  ASP ASP B . n 
B 1 36  PHE 36  68  68  PHE PHE B . n 
B 1 37  GLU 37  69  69  GLU GLU B . n 
B 1 38  LYS 38  70  70  LYS LYS B . n 
B 1 39  ILE 39  71  71  ILE ILE B . n 
B 1 40  SER 40  72  72  SER SER B . n 
B 1 41  GLU 41  73  73  GLU GLU B . n 
B 1 42  LEU 42  74  74  LEU LEU B . n 
B 1 43  GLY 43  75  75  GLY GLY B . n 
B 1 44  ALA 44  76  76  ALA ALA B . n 
B 1 45  GLY 45  77  77  GLY GLY B . n 
B 1 46  ASN 46  78  78  ASN ASN B . n 
B 1 47  GLY 47  79  79  GLY GLY B . n 
B 1 48  GLY 48  80  80  GLY GLY B . n 
B 1 49  VAL 49  81  81  VAL VAL B . n 
B 1 50  VAL 50  82  82  VAL VAL B . n 
B 1 51  PHE 51  83  83  PHE PHE B . n 
B 1 52  LYS 52  84  84  LYS LYS B . n 
B 1 53  VAL 53  85  85  VAL VAL B . n 
B 1 54  SER 54  86  86  SER SER B . n 
B 1 55  HIS 55  87  87  HIS HIS B . n 
B 1 56  LYS 56  88  88  LYS LYS B . n 
B 1 57  PRO 57  89  89  PRO PRO B . n 
B 1 58  SER 58  90  90  SER SER B . n 
B 1 59  GLY 59  91  91  GLY GLY B . n 
B 1 60  LEU 60  92  92  LEU LEU B . n 
B 1 61  VAL 61  93  93  VAL VAL B . n 
B 1 62  MET 62  94  94  MET MET B . n 
B 1 63  ALA 63  95  95  ALA ALA B . n 
B 1 64  ARG 64  96  96  ARG ARG B . n 
B 1 65  LYS 65  97  97  LYS LYS B . n 
B 1 66  LEU 66  98  98  LEU LEU B . n 
B 1 67  ILE 67  99  99  ILE ILE B . n 
B 1 68  HIS 68  100 100 HIS HIS B . n 
B 1 69  LEU 69  101 101 LEU LEU B . n 
B 1 70  GLU 70  102 102 GLU GLU B . n 
B 1 71  ILE 71  103 103 ILE ILE B . n 
B 1 72  LYS 72  104 104 LYS LYS B . n 
B 1 73  PRO 73  105 105 PRO PRO B . n 
B 1 74  ALA 74  106 106 ALA ALA B . n 
B 1 75  ILE 75  107 107 ILE ILE B . n 
B 1 76  ARG 76  108 108 ARG ARG B . n 
B 1 77  ASN 77  109 109 ASN ASN B . n 
B 1 78  GLN 78  110 110 GLN GLN B . n 
B 1 79  ILE 79  111 111 ILE ILE B . n 
B 1 80  ILE 80  112 112 ILE ILE B . n 
B 1 81  ARG 81  113 113 ARG ARG B . n 
B 1 82  GLU 82  114 114 GLU GLU B . n 
B 1 83  LEU 83  115 115 LEU LEU B . n 
B 1 84  GLN 84  116 116 GLN GLN B . n 
B 1 85  VAL 85  117 117 VAL VAL B . n 
B 1 86  LEU 86  118 118 LEU LEU B . n 
B 1 87  HIS 87  119 119 HIS HIS B . n 
B 1 88  GLU 88  120 120 GLU GLU B . n 
B 1 89  CYS 89  121 121 CYS CYS B . n 
B 1 90  ASN 90  122 122 ASN ASN B . n 
B 1 91  SER 91  123 123 SER SER B . n 
B 1 92  PRO 92  124 124 PRO PRO B . n 
B 1 93  TYR 93  125 125 TYR TYR B . n 
B 1 94  ILE 94  126 126 ILE ILE B . n 
B 1 95  VAL 95  127 127 VAL VAL B . n 
B 1 96  GLY 96  128 128 GLY GLY B . n 
B 1 97  PHE 97  129 129 PHE PHE B . n 
B 1 98  TYR 98  130 130 TYR TYR B . n 
B 1 99  GLY 99  131 131 GLY GLY B . n 
B 1 100 ALA 100 132 132 ALA ALA B . n 
B 1 101 PHE 101 133 133 PHE PHE B . n 
B 1 102 TYR 102 134 134 TYR TYR B . n 
B 1 103 SER 103 135 135 SER SER B . n 
B 1 104 ASP 104 136 136 ASP ASP B . n 
B 1 105 GLY 105 137 137 GLY GLY B . n 
B 1 106 GLU 106 138 138 GLU GLU B . n 
B 1 107 ILE 107 139 139 ILE ILE B . n 
B 1 108 SER 108 140 140 SER SER B . n 
B 1 109 ILE 109 141 141 ILE ILE B . n 
B 1 110 CYS 110 142 142 CYS CYS B . n 
B 1 111 MET 111 143 143 MET MET B . n 
B 1 112 GLU 112 144 144 GLU GLU B . n 
B 1 113 HIS 113 145 145 HIS HIS B . n 
B 1 114 MET 114 146 146 MET MET B . n 
B 1 115 ASP 115 147 147 ASP ASP B . n 
B 1 116 GLY 116 148 148 GLY GLY B . n 
B 1 117 GLY 117 149 149 GLY GLY B . n 
B 1 118 SER 118 150 150 SER SER B . n 
B 1 119 LEU 119 151 151 LEU LEU B . n 
B 1 120 ASP 120 152 152 ASP ASP B . n 
B 1 121 GLN 121 153 153 GLN GLN B . n 
B 1 122 VAL 122 154 154 VAL VAL B . n 
B 1 123 LEU 123 155 155 LEU LEU B . n 
B 1 124 LYS 124 156 156 LYS LYS B . n 
B 1 125 LYS 125 157 157 LYS LYS B . n 
B 1 126 ALA 126 158 158 ALA ALA B . n 
B 1 127 GLY 127 159 159 GLY GLY B . n 
B 1 128 ARG 128 160 160 ARG ARG B . n 
B 1 129 ILE 129 161 161 ILE ILE B . n 
B 1 130 PRO 130 162 162 PRO PRO B . n 
B 1 131 GLU 131 163 163 GLU GLU B . n 
B 1 132 GLN 132 164 164 GLN GLN B . n 
B 1 133 ILE 133 165 165 ILE ILE B . n 
B 1 134 LEU 134 166 166 LEU LEU B . n 
B 1 135 GLY 135 167 167 GLY GLY B . n 
B 1 136 LYS 136 168 168 LYS LYS B . n 
B 1 137 VAL 137 169 169 VAL VAL B . n 
B 1 138 SER 138 170 170 SER SER B . n 
B 1 139 ILE 139 171 171 ILE ILE B . n 
B 1 140 ALA 140 172 172 ALA ALA B . n 
B 1 141 VAL 141 173 173 VAL VAL B . n 
B 1 142 ILE 142 174 174 ILE ILE B . n 
B 1 143 LYS 143 175 175 LYS LYS B . n 
B 1 144 GLY 144 176 176 GLY GLY B . n 
B 1 145 LEU 145 177 177 LEU LEU B . n 
B 1 146 THR 146 178 178 THR THR B . n 
B 1 147 TYR 147 179 179 TYR TYR B . n 
B 1 148 LEU 148 180 180 LEU LEU B . n 
B 1 149 ARG 149 181 181 ARG ARG B . n 
B 1 150 GLU 150 182 182 GLU GLU B . n 
B 1 151 LYS 151 183 183 LYS LYS B . n 
B 1 152 HIS 152 184 184 HIS HIS B . n 
B 1 153 LYS 153 185 185 LYS LYS B . n 
B 1 154 ILE 154 186 186 ILE ILE B . n 
B 1 155 MET 155 187 187 MET MET B . n 
B 1 156 HIS 156 188 188 HIS HIS B . n 
B 1 157 ARG 157 189 189 ARG ARG B . n 
B 1 158 ASP 158 190 190 ASP ASP B . n 
B 1 159 VAL 159 191 191 VAL VAL B . n 
B 1 160 LYS 160 192 192 LYS LYS B . n 
B 1 161 PRO 161 193 193 PRO PRO B . n 
B 1 162 SER 162 194 194 SER SER B . n 
B 1 163 ASN 163 195 195 ASN ASN B . n 
B 1 164 ILE 164 196 196 ILE ILE B . n 
B 1 165 LEU 165 197 197 LEU LEU B . n 
B 1 166 VAL 166 198 198 VAL VAL B . n 
B 1 167 ASN 167 199 199 ASN ASN B . n 
B 1 168 SER 168 200 200 SER SER B . n 
B 1 169 ARG 169 201 201 ARG ARG B . n 
B 1 170 GLY 170 202 202 GLY GLY B . n 
B 1 171 GLU 171 203 203 GLU GLU B . n 
B 1 172 ILE 172 204 204 ILE ILE B . n 
B 1 173 LYS 173 205 205 LYS LYS B . n 
B 1 174 LEU 174 206 206 LEU LEU B . n 
B 1 175 CYS 175 207 207 CYS CYS B . n 
B 1 176 ASP 176 208 208 ASP ASP B . n 
B 1 177 PHE 177 209 209 PHE PHE B . n 
B 1 178 GLY 178 210 210 GLY GLY B . n 
B 1 179 VAL 179 211 211 VAL VAL B . n 
B 1 180 SER 180 212 212 SER SER B . n 
B 1 181 GLY 181 213 213 GLY GLY B . n 
B 1 182 GLN 182 214 214 GLN GLN B . n 
B 1 183 LEU 183 215 ?   ?   ?   B . n 
B 1 184 ILE 184 216 ?   ?   ?   B . n 
B 1 185 ASP 185 217 ?   ?   ?   B . n 
B 1 186 SER 186 218 ?   ?   ?   B . n 
B 1 187 MET 187 219 ?   ?   ?   B . n 
B 1 188 ALA 188 220 ?   ?   ?   B . n 
B 1 189 ASN 189 221 ?   ?   ?   B . n 
B 1 190 SER 190 222 ?   ?   ?   B . n 
B 1 191 PHE 191 223 ?   ?   ?   B . n 
B 1 192 VAL 192 224 ?   ?   ?   B . n 
B 1 193 GLY 193 225 ?   ?   ?   B . n 
B 1 194 THR 194 226 226 THR THR B . n 
B 1 195 ARG 195 227 227 ARG ARG B . n 
B 1 196 SER 196 228 228 SER SER B . n 
B 1 197 TYR 197 229 229 TYR TYR B . n 
B 1 198 MET 198 230 230 MET MET B . n 
B 1 199 SER 199 231 231 SER SER B . n 
B 1 200 PRO 200 232 232 PRO PRO B . n 
B 1 201 GLU 201 233 233 GLU GLU B . n 
B 1 202 ARG 202 234 234 ARG ARG B . n 
B 1 203 LEU 203 235 235 LEU LEU B . n 
B 1 204 GLN 204 236 236 GLN GLN B . n 
B 1 205 GLY 205 237 ?   ?   ?   B . n 
B 1 206 THR 206 238 ?   ?   ?   B . n 
B 1 207 HIS 207 239 239 HIS HIS B . n 
B 1 208 TYR 208 240 240 TYR TYR B . n 
B 1 209 SER 209 241 241 SER SER B . n 
B 1 210 VAL 210 242 242 VAL VAL B . n 
B 1 211 GLN 211 243 243 GLN GLN B . n 
B 1 212 SER 212 244 244 SER SER B . n 
B 1 213 ASP 213 245 245 ASP ASP B . n 
B 1 214 ILE 214 246 246 ILE ILE B . n 
B 1 215 TRP 215 247 247 TRP TRP B . n 
B 1 216 SER 216 248 248 SER SER B . n 
B 1 217 MET 217 249 249 MET MET B . n 
B 1 218 GLY 218 250 250 GLY GLY B . n 
B 1 219 LEU 219 251 251 LEU LEU B . n 
B 1 220 SER 220 252 252 SER SER B . n 
B 1 221 LEU 221 253 253 LEU LEU B . n 
B 1 222 VAL 222 254 254 VAL VAL B . n 
B 1 223 GLU 223 255 255 GLU GLU B . n 
B 1 224 MET 224 256 256 MET MET B . n 
B 1 225 ALA 225 257 257 ALA ALA B . n 
B 1 226 VAL 226 258 258 VAL VAL B . n 
B 1 227 GLY 227 259 259 GLY GLY B . n 
B 1 228 ARG 228 260 260 ARG ARG B . n 
B 1 229 TYR 229 261 261 TYR TYR B . n 
B 1 230 PRO 230 262 262 PRO PRO B . n 
B 1 231 ILE 231 263 263 ILE ILE B . n 
B 1 232 PRO 232 264 264 PRO PRO B . n 
B 1 233 PRO 233 265 265 PRO PRO B . n 
B 1 234 PRO 234 266 266 PRO PRO B . n 
B 1 235 ASP 235 267 267 ASP ASP B . n 
B 1 236 ALA 236 268 268 ALA ALA B . n 
B 1 237 LYS 237 269 269 LYS LYS B . n 
B 1 238 GLU 238 270 270 GLU GLU B . n 
B 1 239 LEU 239 271 271 LEU LEU B . n 
B 1 240 GLU 240 272 272 GLU GLU B . n 
B 1 241 LEU 241 273 273 LEU LEU B . n 
B 1 242 MET 242 274 274 MET MET B . n 
B 1 243 PHE 243 275 275 PHE PHE B . n 
B 1 244 GLY 244 276 276 GLY GLY B . n 
B 1 245 CYS 245 277 277 CYS CYS B . n 
B 1 246 GLN 246 278 ?   ?   ?   B . n 
B 1 247 VAL 247 279 ?   ?   ?   B . n 
B 1 248 GLU 248 280 ?   ?   ?   B . n 
B 1 249 GLY 249 281 ?   ?   ?   B . n 
B 1 250 ASP 250 282 ?   ?   ?   B . n 
B 1 251 ALA 251 283 ?   ?   ?   B . n 
B 1 252 ALA 252 284 ?   ?   ?   B . n 
B 1 253 GLU 253 285 ?   ?   ?   B . n 
B 1 254 ALA 254 286 ?   ?   ?   B . n 
B 1 255 PRO 255 287 ?   ?   ?   B . n 
B 1 256 PRO 256 288 ?   ?   ?   B . n 
B 1 257 ARG 257 289 ?   ?   ?   B . n 
B 1 258 PRO 258 290 ?   ?   ?   B . n 
B 1 259 ARG 259 291 ?   ?   ?   B . n 
B 1 260 ALA 260 292 ?   ?   ?   B . n 
B 1 261 PRO 261 293 ?   ?   ?   B . n 
B 1 262 GLY 262 294 ?   ?   ?   B . n 
B 1 263 ARG 263 295 ?   ?   ?   B . n 
B 1 264 PRO 264 296 ?   ?   ?   B . n 
B 1 265 LEU 265 297 ?   ?   ?   B . n 
B 1 266 ALA 266 298 ?   ?   ?   B . n 
B 1 267 SER 267 299 ?   ?   ?   B . n 
B 1 268 TYR 268 300 ?   ?   ?   B . n 
B 1 269 GLY 269 301 ?   ?   ?   B . n 
B 1 270 MET 270 302 ?   ?   ?   B . n 
B 1 271 ASP 271 303 ?   ?   ?   B . n 
B 1 272 SER 272 304 ?   ?   ?   B . n 
B 1 273 ARG 273 305 ?   ?   ?   B . n 
B 1 274 PRO 274 306 ?   ?   ?   B . n 
B 1 275 PRO 275 307 307 PRO PRO B . n 
B 1 276 MET 276 308 308 MET MET B . n 
B 1 277 ALA 277 309 309 ALA ALA B . n 
B 1 278 ILE 278 310 310 ILE ILE B . n 
B 1 279 PHE 279 311 311 PHE PHE B . n 
B 1 280 GLU 280 312 312 GLU GLU B . n 
B 1 281 LEU 281 313 313 LEU LEU B . n 
B 1 282 LEU 282 314 314 LEU LEU B . n 
B 1 283 ASP 283 315 315 ASP ASP B . n 
B 1 284 TYR 284 316 316 TYR TYR B . n 
B 1 285 ILE 285 317 317 ILE ILE B . n 
B 1 286 VAL 286 318 318 VAL VAL B . n 
B 1 287 ASN 287 319 319 ASN ASN B . n 
B 1 288 GLU 288 320 320 GLU GLU B . n 
B 1 289 PRO 289 321 321 PRO PRO B . n 
B 1 290 PRO 290 322 322 PRO PRO B . n 
B 1 291 PRO 291 323 323 PRO PRO B . n 
B 1 292 LYS 292 324 324 LYS LYS B . n 
B 1 293 LEU 293 325 325 LEU LEU B . n 
B 1 294 PRO 294 326 326 PRO PRO B . n 
B 1 295 SER 295 327 327 SER SER B . n 
B 1 296 GLY 296 328 328 GLY GLY B . n 
B 1 297 VAL 297 329 329 VAL VAL B . n 
B 1 298 PHE 298 330 330 PHE PHE B . n 
B 1 299 SER 299 331 331 SER SER B . n 
B 1 300 LEU 300 332 332 LEU LEU B . n 
B 1 301 GLU 301 333 333 GLU GLU B . n 
B 1 302 PHE 302 334 334 PHE PHE B . n 
B 1 303 GLN 303 335 335 GLN GLN B . n 
B 1 304 ASP 304 336 336 ASP ASP B . n 
B 1 305 PHE 305 337 337 PHE PHE B . n 
B 1 306 VAL 306 338 338 VAL VAL B . n 
B 1 307 ASN 307 339 339 ASN ASN B . n 
B 1 308 LYS 308 340 340 LYS LYS B . n 
B 1 309 CYS 309 341 341 CYS CYS B . n 
B 1 310 LEU 310 342 342 LEU LEU B . n 
B 1 311 ILE 311 343 343 ILE ILE B . n 
B 1 312 LYS 312 344 344 LYS LYS B . n 
B 1 313 ASN 313 345 345 ASN ASN B . n 
B 1 314 PRO 314 346 346 PRO PRO B . n 
B 1 315 ALA 315 347 347 ALA ALA B . n 
B 1 316 GLU 316 348 348 GLU GLU B . n 
B 1 317 ARG 317 349 349 ARG ARG B . n 
B 1 318 ALA 318 350 350 ALA ALA B . n 
B 1 319 ASP 319 351 351 ASP ASP B . n 
B 1 320 LEU 320 352 352 LEU LEU B . n 
B 1 321 LYS 321 353 353 LYS LYS B . n 
B 1 322 GLN 322 354 354 GLN GLN B . n 
B 1 323 LEU 323 355 355 LEU LEU B . n 
B 1 324 MET 324 356 356 MET MET B . n 
B 1 325 VAL 325 357 357 VAL VAL B . n 
B 1 326 HIS 326 358 358 HIS HIS B . n 
B 1 327 ALA 327 359 359 ALA ALA B . n 
B 1 328 PHE 328 360 360 PHE PHE B . n 
B 1 329 ILE 329 361 361 ILE ILE B . n 
B 1 330 LYS 330 362 362 LYS LYS B . n 
B 1 331 ARG 331 363 363 ARG ARG B . n 
B 1 332 SER 332 364 364 SER SER B . n 
B 1 333 ASP 333 365 365 ASP ASP B . n 
B 1 334 ALA 334 366 366 ALA ALA B . n 
B 1 335 GLU 335 367 367 GLU GLU B . n 
B 1 336 GLU 336 368 368 GLU GLU B . n 
B 1 337 VAL 337 369 369 VAL VAL B . n 
B 1 338 ASP 338 370 370 ASP ASP B . n 
B 1 339 PHE 339 371 371 PHE PHE B . n 
B 1 340 ALA 340 372 372 ALA ALA B . n 
B 1 341 GLY 341 373 373 GLY GLY B . n 
B 1 342 TRP 342 374 374 TRP TRP B . n 
B 1 343 LEU 343 375 375 LEU LEU B . n 
B 1 344 CYS 344 376 376 CYS CYS B . n 
B 1 345 SER 345 377 377 SER SER B . n 
B 1 346 THR 346 378 378 THR THR B . n 
B 1 347 ILE 347 379 379 ILE ILE B . n 
B 1 348 GLY 348 380 380 GLY GLY B . n 
B 1 349 LEU 349 381 381 LEU LEU B . n 
B 1 350 ASN 350 382 382 ASN ASN B . n 
B 1 351 GLN 351 383 383 GLN GLN B . n 
B 1 352 PRO 352 384 ?   ?   ?   B . n 
B 1 353 SER 353 385 ?   ?   ?   B . n 
B 1 354 THR 354 386 ?   ?   ?   B . n 
B 1 355 ALA 355 387 ?   ?   ?   B . n 
B 1 356 ALA 356 388 ?   ?   ?   B . n 
B 1 357 ALA 357 389 ?   ?   ?   B . n 
B 1 358 LEU 358 390 ?   ?   ?   B . n 
B 1 359 GLU 359 391 ?   ?   ?   B . n 
B 1 360 HIS 360 392 ?   ?   ?   B . n 
B 1 361 HIS 361 393 ?   ?   ?   B . n 
B 1 362 HIS 362 394 ?   ?   ?   B . n 
B 1 363 HIS 363 395 ?   ?   ?   B . n 
B 1 364 HIS 364 396 ?   ?   ?   B . n 
B 1 365 HIS 365 397 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        WNT 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   WNT 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 WNT 1  401 401 WNT 2FM A . 
D 3 GOL 1  401 402 GOL GOL B . 
E 2 WNT 1  402 403 WNT 2FM B . 
F 4 HOH 1  501 155 HOH HOH A . 
F 4 HOH 2  502 137 HOH HOH A . 
F 4 HOH 3  503 28  HOH HOH A . 
F 4 HOH 4  504 35  HOH HOH A . 
F 4 HOH 5  505 33  HOH HOH A . 
F 4 HOH 6  506 103 HOH HOH A . 
F 4 HOH 7  507 132 HOH HOH A . 
F 4 HOH 8  508 39  HOH HOH A . 
F 4 HOH 9  509 11  HOH HOH A . 
F 4 HOH 10 510 3   HOH HOH A . 
F 4 HOH 11 511 1   HOH HOH A . 
F 4 HOH 12 512 152 HOH HOH A . 
F 4 HOH 13 513 107 HOH HOH A . 
F 4 HOH 14 514 52  HOH HOH A . 
F 4 HOH 15 515 90  HOH HOH A . 
F 4 HOH 16 516 27  HOH HOH A . 
F 4 HOH 17 517 122 HOH HOH A . 
F 4 HOH 18 518 63  HOH HOH A . 
F 4 HOH 19 519 80  HOH HOH A . 
F 4 HOH 20 520 102 HOH HOH A . 
F 4 HOH 21 521 51  HOH HOH A . 
F 4 HOH 22 522 82  HOH HOH A . 
F 4 HOH 23 523 150 HOH HOH A . 
F 4 HOH 24 524 76  HOH HOH A . 
F 4 HOH 25 525 141 HOH HOH A . 
F 4 HOH 26 526 83  HOH HOH A . 
F 4 HOH 27 527 88  HOH HOH A . 
F 4 HOH 28 528 97  HOH HOH A . 
F 4 HOH 29 529 189 HOH HOH A . 
F 4 HOH 30 530 30  HOH HOH A . 
F 4 HOH 31 531 34  HOH HOH A . 
F 4 HOH 32 532 143 HOH HOH A . 
F 4 HOH 33 533 81  HOH HOH A . 
F 4 HOH 34 534 144 HOH HOH A . 
F 4 HOH 35 535 136 HOH HOH A . 
F 4 HOH 36 536 140 HOH HOH A . 
F 4 HOH 37 537 86  HOH HOH A . 
F 4 HOH 38 538 79  HOH HOH A . 
F 4 HOH 39 539 36  HOH HOH A . 
F 4 HOH 40 540 133 HOH HOH A . 
F 4 HOH 41 541 55  HOH HOH A . 
F 4 HOH 42 542 22  HOH HOH A . 
F 4 HOH 43 543 138 HOH HOH A . 
F 4 HOH 44 544 139 HOH HOH A . 
F 4 HOH 45 545 87  HOH HOH A . 
F 4 HOH 46 546 37  HOH HOH A . 
F 4 HOH 47 547 26  HOH HOH A . 
F 4 HOH 48 548 31  HOH HOH A . 
F 4 HOH 49 549 142 HOH HOH A . 
F 4 HOH 50 550 160 HOH HOH A . 
F 4 HOH 51 551 41  HOH HOH A . 
F 4 HOH 52 552 38  HOH HOH A . 
F 4 HOH 53 553 21  HOH HOH A . 
F 4 HOH 54 554 4   HOH HOH A . 
F 4 HOH 55 555 145 HOH HOH A . 
F 4 HOH 56 556 74  HOH HOH A . 
F 4 HOH 57 557 194 HOH HOH A . 
F 4 HOH 58 558 156 HOH HOH A . 
F 4 HOH 59 559 158 HOH HOH A . 
F 4 HOH 60 560 148 HOH HOH A . 
F 4 HOH 61 561 108 HOH HOH A . 
F 4 HOH 62 562 25  HOH HOH A . 
F 4 HOH 63 563 159 HOH HOH A . 
F 4 HOH 64 564 135 HOH HOH A . 
F 4 HOH 65 565 100 HOH HOH A . 
F 4 HOH 66 566 42  HOH HOH A . 
F 4 HOH 67 567 96  HOH HOH A . 
F 4 HOH 68 568 53  HOH HOH A . 
F 4 HOH 69 569 98  HOH HOH A . 
F 4 HOH 70 570 164 HOH HOH A . 
F 4 HOH 71 571 106 HOH HOH A . 
F 4 HOH 72 572 191 HOH HOH A . 
F 4 HOH 73 573 128 HOH HOH A . 
F 4 HOH 74 574 153 HOH HOH A . 
F 4 HOH 75 575 54  HOH HOH A . 
G 4 HOH 1  501 188 HOH HOH B . 
G 4 HOH 2  502 125 HOH HOH B . 
G 4 HOH 3  503 14  HOH HOH B . 
G 4 HOH 4  504 61  HOH HOH B . 
G 4 HOH 5  505 169 HOH HOH B . 
G 4 HOH 6  506 50  HOH HOH B . 
G 4 HOH 7  507 12  HOH HOH B . 
G 4 HOH 8  508 45  HOH HOH B . 
G 4 HOH 9  509 72  HOH HOH B . 
G 4 HOH 10 510 180 HOH HOH B . 
G 4 HOH 11 511 10  HOH HOH B . 
G 4 HOH 12 512 49  HOH HOH B . 
G 4 HOH 13 513 172 HOH HOH B . 
G 4 HOH 14 514 6   HOH HOH B . 
G 4 HOH 15 515 43  HOH HOH B . 
G 4 HOH 16 516 19  HOH HOH B . 
G 4 HOH 17 517 119 HOH HOH B . 
G 4 HOH 18 518 151 HOH HOH B . 
G 4 HOH 19 519 64  HOH HOH B . 
G 4 HOH 20 520 171 HOH HOH B . 
G 4 HOH 21 521 67  HOH HOH B . 
G 4 HOH 22 522 2   HOH HOH B . 
G 4 HOH 23 523 15  HOH HOH B . 
G 4 HOH 24 524 177 HOH HOH B . 
G 4 HOH 25 525 70  HOH HOH B . 
G 4 HOH 26 526 120 HOH HOH B . 
G 4 HOH 27 527 187 HOH HOH B . 
G 4 HOH 28 528 84  HOH HOH B . 
G 4 HOH 29 529 124 HOH HOH B . 
G 4 HOH 30 530 71  HOH HOH B . 
G 4 HOH 31 531 118 HOH HOH B . 
G 4 HOH 32 532 17  HOH HOH B . 
G 4 HOH 33 533 178 HOH HOH B . 
G 4 HOH 34 534 184 HOH HOH B . 
G 4 HOH 35 535 182 HOH HOH B . 
G 4 HOH 36 536 176 HOH HOH B . 
G 4 HOH 37 537 66  HOH HOH B . 
G 4 HOH 38 538 16  HOH HOH B . 
G 4 HOH 39 539 18  HOH HOH B . 
G 4 HOH 40 540 93  HOH HOH B . 
G 4 HOH 41 541 9   HOH HOH B . 
G 4 HOH 42 542 121 HOH HOH B . 
G 4 HOH 43 543 154 HOH HOH B . 
G 4 HOH 44 544 126 HOH HOH B . 
G 4 HOH 45 545 65  HOH HOH B . 
G 4 HOH 46 546 78  HOH HOH B . 
G 4 HOH 47 547 161 HOH HOH B . 
G 4 HOH 48 548 62  HOH HOH B . 
G 4 HOH 49 549 167 HOH HOH B . 
G 4 HOH 50 550 190 HOH HOH B . 
G 4 HOH 51 551 123 HOH HOH B . 
G 4 HOH 52 552 60  HOH HOH B . 
G 4 HOH 53 553 179 HOH HOH B . 
G 4 HOH 54 554 181 HOH HOH B . 
G 4 HOH 55 555 192 HOH HOH B . 
G 4 HOH 56 556 193 HOH HOH B . 
G 4 HOH 57 557 149 HOH HOH B . 
G 4 HOH 58 558 91  HOH HOH B . 
G 4 HOH 59 559 89  HOH HOH B . 
G 4 HOH 60 560 130 HOH HOH B . 
G 4 HOH 61 561 92  HOH HOH B . 
G 4 HOH 62 562 46  HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   94.86 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YP4 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     47.364 
_cell.length_a_esd                 ? 
_cell.length_b                     128.947 
_cell.length_b_esd                 ? 
_cell.length_c                     65.689 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YP4 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YP4 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.44 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.68 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '8% Tacsimete pH 5.0, 19.5% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL44XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL44XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YP4 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.35 
_reflns.d_resolution_low                               47.194 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     32615 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.15 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.35 
_reflns_shell.d_res_low                                     2.49 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             17348 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.573 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -3.47 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            1.77 
_refine.aniso_B[2][2]                            -3.69 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            6.76 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               94.273 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.965 
_refine.correlation_coeff_Fo_to_Fc_free          0.930 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YP4 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.35 
_refine.ls_d_res_low                             45.93 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     30955 
_refine.ls_number_reflns_R_free                  1629 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.59 
_refine.ls_percent_reflns_R_free                 5.0 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.21023 
_refine.ls_R_factor_R_free                       0.28403 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20631 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.331 
_refine.pdbx_overall_ESU_R_Free                  0.272 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             15.533 
_refine.overall_SU_ML                            0.331 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.35 
_refine_hist.d_res_low                        45.93 
_refine_hist.number_atoms_solvent             137 
_refine_hist.number_atoms_total               4969 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4832 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  4932  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.016  4834  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.426  1.852  6627  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.548  1.780  11183 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.492  5.000  597   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 7.871  5.000  28    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 18.884 10.000 921   ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.210  0.200  726   ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.005  0.020  5626  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1054  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 6.903  9.404  2412  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 6.902  9.404  2412  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 10.652 16.867 3001  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 10.650 16.870 3002  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 6.339  10.048 2520  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 6.338  10.048 2520  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 10.192 18.262 3627  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 15.467 90.04  5575  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 15.478 90.09  5564  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.35 
_refine_ls_shell.d_res_low                        2.409 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             116 
_refine_ls_shell.number_reflns_R_work             2211 
_refine_ls_shell.percent_reflns_obs               98.48 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.433 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.434 
# 
_struct.entry_id                     8YP4 
_struct.title                        'Structure of MAP2K1 complexed with 5Z7-oxozeaenol' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YP4 
_struct_keywords.text            'Mitogen-activated protein kinase kinase 1, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 4 ? 
G N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    MP2K1_HUMAN 
_struct_ref.pdbx_db_accession          Q02750 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR
ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP
SNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL
MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK
QLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPST
;
_struct_ref.pdbx_align_begin           34 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YP4 A 2 ? 354 ? Q02750 34 ? 386 ? 34 386 
2 1 8YP4 B 2 ? 354 ? Q02750 34 ? 386 ? 34 386 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YP4 MET A 1   ? UNP Q02750 ?   ?   'initiating methionine' 33  1  
1 8YP4 ALA A 254 ? UNP Q02750 THR 286 'engineered mutation'   286 2  
1 8YP4 ALA A 260 ? UNP Q02750 THR 292 'engineered mutation'   292 3  
1 8YP4 ALA A 266 ? UNP Q02750 SER 298 'engineered mutation'   298 4  
1 8YP4 ALA A 355 ? UNP Q02750 ?   ?   'expression tag'        387 5  
1 8YP4 ALA A 356 ? UNP Q02750 ?   ?   'expression tag'        388 6  
1 8YP4 ALA A 357 ? UNP Q02750 ?   ?   'expression tag'        389 7  
1 8YP4 LEU A 358 ? UNP Q02750 ?   ?   'expression tag'        390 8  
1 8YP4 GLU A 359 ? UNP Q02750 ?   ?   'expression tag'        391 9  
1 8YP4 HIS A 360 ? UNP Q02750 ?   ?   'expression tag'        392 10 
1 8YP4 HIS A 361 ? UNP Q02750 ?   ?   'expression tag'        393 11 
1 8YP4 HIS A 362 ? UNP Q02750 ?   ?   'expression tag'        394 12 
1 8YP4 HIS A 363 ? UNP Q02750 ?   ?   'expression tag'        395 13 
1 8YP4 HIS A 364 ? UNP Q02750 ?   ?   'expression tag'        396 14 
1 8YP4 HIS A 365 ? UNP Q02750 ?   ?   'expression tag'        397 15 
2 8YP4 MET B 1   ? UNP Q02750 ?   ?   'initiating methionine' 33  16 
2 8YP4 ALA B 254 ? UNP Q02750 THR 286 'engineered mutation'   286 17 
2 8YP4 ALA B 260 ? UNP Q02750 THR 292 'engineered mutation'   292 18 
2 8YP4 ALA B 266 ? UNP Q02750 SER 298 'engineered mutation'   298 19 
2 8YP4 ALA B 355 ? UNP Q02750 ?   ?   'expression tag'        387 20 
2 8YP4 ALA B 356 ? UNP Q02750 ?   ?   'expression tag'        388 21 
2 8YP4 ALA B 357 ? UNP Q02750 ?   ?   'expression tag'        389 22 
2 8YP4 LEU B 358 ? UNP Q02750 ?   ?   'expression tag'        390 23 
2 8YP4 GLU B 359 ? UNP Q02750 ?   ?   'expression tag'        391 24 
2 8YP4 HIS B 360 ? UNP Q02750 ?   ?   'expression tag'        392 25 
2 8YP4 HIS B 361 ? UNP Q02750 ?   ?   'expression tag'        393 26 
2 8YP4 HIS B 362 ? UNP Q02750 ?   ?   'expression tag'        394 27 
2 8YP4 HIS B 363 ? UNP Q02750 ?   ?   'expression tag'        395 28 
2 8YP4 HIS B 364 ? UNP Q02750 ?   ?   'expression tag'        396 29 
2 8YP4 HIS B 365 ? UNP Q02750 ?   ?   'expression tag'        397 30 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,F   
2 1 B,D,E,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 11  ? LYS A 27  ? ASP A 43  LYS A 59  1 ? 17 
HELX_P HELX_P2  AA2 LYS A 32  ? ASP A 34  ? LYS A 64  ASP A 66  5 ? 3  
HELX_P HELX_P3  AA3 ILE A 75  ? GLN A 84  ? ILE A 107 GLN A 116 1 ? 10 
HELX_P HELX_P4  AA4 VAL A 85  ? HIS A 87  ? VAL A 117 HIS A 119 5 ? 3  
HELX_P HELX_P5  AA5 LEU A 119 ? GLY A 127 ? LEU A 151 GLY A 159 1 ? 9  
HELX_P HELX_P6  AA6 PRO A 130 ? GLU A 150 ? PRO A 162 GLU A 182 1 ? 21 
HELX_P HELX_P7  AA7 LYS A 160 ? SER A 162 ? LYS A 192 SER A 194 5 ? 3  
HELX_P HELX_P8  AA8 PRO A 200 ? GLN A 204 ? PRO A 232 GLN A 236 5 ? 5  
HELX_P HELX_P9  AA9 SER A 209 ? GLY A 227 ? SER A 241 GLY A 259 1 ? 19 
HELX_P HELX_P10 AB1 GLU A 238 ? PHE A 243 ? GLU A 270 PHE A 275 1 ? 6  
HELX_P HELX_P11 AB2 ILE A 278 ? GLU A 288 ? ILE A 310 GLU A 320 1 ? 11 
HELX_P HELX_P12 AB3 SER A 299 ? LEU A 310 ? SER A 331 LEU A 342 1 ? 12 
HELX_P HELX_P13 AB4 ASP A 319 ? VAL A 325 ? ASP A 351 VAL A 357 1 ? 7  
HELX_P HELX_P14 AB5 HIS A 326 ? GLU A 335 ? HIS A 358 GLU A 367 1 ? 10 
HELX_P HELX_P15 AB6 ASP A 338 ? GLY A 348 ? ASP A 370 GLY A 380 1 ? 11 
HELX_P HELX_P16 AB7 GLU B 12  ? LYS B 27  ? GLU B 44  LYS B 59  1 ? 16 
HELX_P HELX_P17 AB8 LYS B 32  ? ASP B 34  ? LYS B 64  ASP B 66  5 ? 3  
HELX_P HELX_P18 AB9 ILE B 75  ? GLN B 84  ? ILE B 107 GLN B 116 1 ? 10 
HELX_P HELX_P19 AC1 VAL B 85  ? GLU B 88  ? VAL B 117 GLU B 120 5 ? 4  
HELX_P HELX_P20 AC2 LEU B 119 ? GLY B 127 ? LEU B 151 GLY B 159 1 ? 9  
HELX_P HELX_P21 AC3 PRO B 130 ? GLU B 150 ? PRO B 162 GLU B 182 1 ? 21 
HELX_P HELX_P22 AC4 LYS B 160 ? SER B 162 ? LYS B 192 SER B 194 5 ? 3  
HELX_P HELX_P23 AC5 SER B 209 ? GLY B 227 ? SER B 241 GLY B 259 1 ? 19 
HELX_P HELX_P24 AC6 ASP B 235 ? GLY B 244 ? ASP B 267 GLY B 276 1 ? 10 
HELX_P HELX_P25 AC7 ALA B 277 ? GLU B 288 ? ALA B 309 GLU B 320 1 ? 12 
HELX_P HELX_P26 AC8 SER B 299 ? LEU B 310 ? SER B 331 LEU B 342 1 ? 12 
HELX_P HELX_P27 AC9 ASP B 319 ? VAL B 325 ? ASP B 351 VAL B 357 1 ? 7  
HELX_P HELX_P28 AD1 HIS B 326 ? GLU B 335 ? HIS B 358 GLU B 367 1 ? 10 
HELX_P HELX_P29 AD2 ASP B 338 ? GLY B 348 ? ASP B 370 GLY B 380 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 175 SG ? ? ? 1_555 C WNT . C14 ? ? A CYS 207 A WNT 401 1_555 ? ? ? ? ? ? ? 1.807 ? ? 
covale2 covale none ? B CYS 175 SG ? ? ? 1_555 E WNT . C14 ? ? B CYS 207 B WNT 402 1_555 ? ? ? ? ? ? ? 1.876 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 WNT C . ? CYS A 175 ? WNT A 401 ? 1_555 CYS A 207 ? 1_555 C14 SG CYS 1 WNT None 'Covalent chemical modification' 
2 WNT E . ? CYS B 175 ? WNT B 402 ? 1_555 CYS B 207 ? 1_555 C14 SG CYS 1 WNT None 'Covalent chemical modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ILE 231 A . ? ILE 263 A PRO 232 A ? PRO 264 A 1 10.51 
2 ILE 231 B . ? ILE 263 B PRO 232 B ? PRO 264 B 1 9.48  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 5 ? 
AA4 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 36  ? LEU A 42  ? PHE A 68  LEU A 74  
AA1 2 VAL A 50  ? HIS A 55  ? VAL A 82  HIS A 87  
AA1 3 LEU A 60  ? HIS A 68  ? LEU A 92  HIS A 100 
AA1 4 GLU A 106 ? GLU A 112 ? GLU A 138 GLU A 144 
AA1 5 PHE A 97  ? SER A 103 ? PHE A 129 SER A 135 
AA2 1 GLY A 117 ? SER A 118 ? GLY A 149 SER A 150 
AA2 2 ILE A 164 ? VAL A 166 ? ILE A 196 VAL A 198 
AA2 3 ILE A 172 ? LEU A 174 ? ILE A 204 LEU A 206 
AA3 1 PHE B 36  ? GLU B 41  ? PHE B 68  GLU B 73  
AA3 2 VAL B 49  ? HIS B 55  ? VAL B 81  HIS B 87  
AA3 3 LEU B 60  ? ILE B 67  ? LEU B 92  ILE B 99  
AA3 4 GLU B 106 ? MET B 111 ? GLU B 138 MET B 143 
AA3 5 PHE B 97  ? SER B 103 ? PHE B 129 SER B 135 
AA4 1 GLY B 117 ? SER B 118 ? GLY B 149 SER B 150 
AA4 2 ILE B 164 ? VAL B 166 ? ILE B 196 VAL B 198 
AA4 3 ILE B 172 ? LEU B 174 ? ILE B 204 LEU B 206 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLU A 37  ? N GLU A 69  O SER A 54  ? O SER A 86  
AA1 2 3 N PHE A 51  ? N PHE A 83  O ARG A 64  ? O ARG A 96  
AA1 3 4 N ALA A 63  ? N ALA A 95  O MET A 111 ? O MET A 143 
AA1 4 5 O CYS A 110 ? O CYS A 142 N TYR A 98  ? N TYR A 130 
AA2 1 2 N GLY A 117 ? N GLY A 149 O VAL A 166 ? O VAL A 198 
AA2 2 3 N LEU A 165 ? N LEU A 197 O LYS A 173 ? O LYS A 205 
AA3 1 2 N ILE B 39  ? N ILE B 71  O LYS B 52  ? O LYS B 84  
AA3 2 3 N PHE B 51  ? N PHE B 83  O ARG B 64  ? O ARG B 96  
AA3 3 4 N LYS B 65  ? N LYS B 97  O ILE B 109 ? O ILE B 141 
AA3 4 5 O CYS B 110 ? O CYS B 142 N GLY B 99  ? N GLY B 131 
AA4 1 2 N GLY B 117 ? N GLY B 149 O VAL B 166 ? O VAL B 198 
AA4 2 3 N LEU B 165 ? N LEU B 197 O LYS B 173 ? O LYS B 205 
# 
_pdbx_entry_details.entry_id                   8YP4 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             N 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_1              105 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_2              105 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_3              105 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                95.45 
_pdbx_validate_rmsd_angle.angle_target_value         103.30 
_pdbx_validate_rmsd_angle.angle_deviation            -7.85 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.20 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 37  ? ? 46.83   71.31   
2  1 GLU A 39  ? ? -140.85 -95.29  
3  1 LEU A 40  ? ? 174.09  -168.06 
4  1 ASP A 43  ? ? -25.75  108.00  
5  1 GLU A 44  ? ? -30.00  -33.36  
6  1 ALA A 76  ? ? -102.69 -165.91 
7  1 ASN A 78  ? ? 36.65   -133.89 
8  1 ILE A 103 ? ? 91.49   139.35  
9  1 LYS A 104 ? ? -156.97 69.89   
10 1 PRO A 105 ? ? -116.05 73.14   
11 1 ALA A 106 ? ? 61.97   -48.37  
12 1 SER A 135 ? ? -171.68 131.68  
13 1 GLU A 182 ? ? -103.73 40.75   
14 1 LYS A 183 ? ? -172.38 -76.78  
15 1 HIS A 188 ? ? 70.59   -102.97 
16 1 ARG A 189 ? ? 160.56  -67.88  
17 1 ASP A 208 ? ? -28.46  108.03  
18 1 THR A 226 ? ? 101.02  -24.75  
19 1 SER A 241 ? ? 76.98   167.91  
20 1 ASP A 267 ? ? 40.40   -82.82  
21 1 ALA A 268 ? ? -51.37  91.89   
22 1 LYS A 269 ? ? 30.58   -94.33  
23 1 GLU A 270 ? ? 51.57   -54.96  
24 1 VAL B 60  ? ? -74.28  -82.41  
25 1 LEU B 74  ? ? -176.02 113.25  
26 1 ALA B 76  ? ? -169.15 20.65   
27 1 ASN B 78  ? ? 67.74   -119.28 
28 1 PRO B 105 ? ? -76.64  34.78   
29 1 ALA B 106 ? ? -149.76 -24.93  
30 1 ASN B 122 ? ? -153.11 88.41   
31 1 SER B 135 ? ? -176.77 144.40  
32 1 GLU B 182 ? ? -57.50  -84.96  
33 1 LYS B 183 ? ? -56.70  102.45  
34 1 HIS B 184 ? ? 52.52   160.70  
35 1 LYS B 185 ? ? -90.21  33.10   
36 1 MET B 187 ? ? 51.48   -137.40 
37 1 HIS B 188 ? ? 49.23   166.44  
38 1 ARG B 189 ? ? 96.35   147.86  
39 1 SER B 200 ? ? -69.09  0.89    
40 1 ASP B 208 ? ? -94.09  -121.26 
41 1 PHE B 209 ? ? 66.37   140.13  
42 1 VAL B 211 ? ? -38.82  140.45  
43 1 SER B 212 ? ? 66.94   -140.92 
44 1 ARG B 227 ? ? 78.91   128.14  
45 1 SER B 228 ? ? 121.59  -95.83  
46 1 TYR B 229 ? ? 53.15   15.81   
47 1 TYR B 240 ? ? 176.69  123.03  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 363 ? ? 0.116 'SIDE CHAIN' 
2 1 ARG B 49  ? ? 0.081 'SIDE CHAIN' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 575 ? 5.86 . 
2 1 O ? B HOH 561 ? 6.06 . 
3 1 O ? B HOH 562 ? 6.71 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 33  ? A MET 1   
2   1 Y 1 A GLU 120 ? A GLU 88  
3   1 Y 1 A LEU 215 ? A LEU 183 
4   1 Y 1 A ILE 216 ? A ILE 184 
5   1 Y 1 A ASP 217 ? A ASP 185 
6   1 Y 1 A SER 218 ? A SER 186 
7   1 Y 1 A MET 219 ? A MET 187 
8   1 Y 1 A ALA 220 ? A ALA 188 
9   1 Y 1 A ASN 221 ? A ASN 189 
10  1 Y 1 A SER 222 ? A SER 190 
11  1 Y 1 A PHE 223 ? A PHE 191 
12  1 Y 1 A GLY 237 ? A GLY 205 
13  1 Y 1 A THR 238 ? A THR 206 
14  1 Y 1 A HIS 239 ? A HIS 207 
15  1 Y 1 A GLY 276 ? A GLY 244 
16  1 Y 1 A CYS 277 ? A CYS 245 
17  1 Y 1 A GLN 278 ? A GLN 246 
18  1 Y 1 A VAL 279 ? A VAL 247 
19  1 Y 1 A GLU 280 ? A GLU 248 
20  1 Y 1 A GLY 281 ? A GLY 249 
21  1 Y 1 A ASP 282 ? A ASP 250 
22  1 Y 1 A ALA 283 ? A ALA 251 
23  1 Y 1 A ALA 284 ? A ALA 252 
24  1 Y 1 A GLU 285 ? A GLU 253 
25  1 Y 1 A ALA 286 ? A ALA 254 
26  1 Y 1 A PRO 287 ? A PRO 255 
27  1 Y 1 A PRO 288 ? A PRO 256 
28  1 Y 1 A ARG 289 ? A ARG 257 
29  1 Y 1 A PRO 290 ? A PRO 258 
30  1 Y 1 A ARG 291 ? A ARG 259 
31  1 Y 1 A ALA 292 ? A ALA 260 
32  1 Y 1 A PRO 293 ? A PRO 261 
33  1 Y 1 A GLY 294 ? A GLY 262 
34  1 Y 1 A ARG 295 ? A ARG 263 
35  1 Y 1 A PRO 296 ? A PRO 264 
36  1 Y 1 A LEU 297 ? A LEU 265 
37  1 Y 1 A ALA 298 ? A ALA 266 
38  1 Y 1 A SER 299 ? A SER 267 
39  1 Y 1 A TYR 300 ? A TYR 268 
40  1 Y 1 A GLY 301 ? A GLY 269 
41  1 Y 1 A MET 302 ? A MET 270 
42  1 Y 1 A ASP 303 ? A ASP 271 
43  1 Y 1 A SER 304 ? A SER 272 
44  1 Y 1 A ARG 305 ? A ARG 273 
45  1 Y 1 A PRO 306 ? A PRO 274 
46  1 Y 1 A PRO 307 ? A PRO 275 
47  1 Y 1 A MET 308 ? A MET 276 
48  1 Y 1 A SER 385 ? A SER 353 
49  1 Y 1 A THR 386 ? A THR 354 
50  1 Y 1 A ALA 387 ? A ALA 355 
51  1 Y 1 A ALA 388 ? A ALA 356 
52  1 Y 1 A ALA 389 ? A ALA 357 
53  1 Y 1 A LEU 390 ? A LEU 358 
54  1 Y 1 A GLU 391 ? A GLU 359 
55  1 Y 1 A HIS 392 ? A HIS 360 
56  1 Y 1 A HIS 393 ? A HIS 361 
57  1 Y 1 A HIS 394 ? A HIS 362 
58  1 Y 1 A HIS 395 ? A HIS 363 
59  1 Y 1 A HIS 396 ? A HIS 364 
60  1 Y 1 A HIS 397 ? A HIS 365 
61  1 Y 1 B MET 33  ? B MET 1   
62  1 Y 1 B GLN 34  ? B GLN 2   
63  1 Y 1 B LYS 35  ? B LYS 3   
64  1 Y 1 B LYS 36  ? B LYS 4   
65  1 Y 1 B LEU 37  ? B LEU 5   
66  1 Y 1 B GLU 38  ? B GLU 6   
67  1 Y 1 B GLU 39  ? B GLU 7   
68  1 Y 1 B LEU 40  ? B LEU 8   
69  1 Y 1 B GLU 41  ? B GLU 9   
70  1 Y 1 B LEU 42  ? B LEU 10  
71  1 Y 1 B LEU 215 ? B LEU 183 
72  1 Y 1 B ILE 216 ? B ILE 184 
73  1 Y 1 B ASP 217 ? B ASP 185 
74  1 Y 1 B SER 218 ? B SER 186 
75  1 Y 1 B MET 219 ? B MET 187 
76  1 Y 1 B ALA 220 ? B ALA 188 
77  1 Y 1 B ASN 221 ? B ASN 189 
78  1 Y 1 B SER 222 ? B SER 190 
79  1 Y 1 B PHE 223 ? B PHE 191 
80  1 Y 1 B VAL 224 ? B VAL 192 
81  1 Y 1 B GLY 225 ? B GLY 193 
82  1 Y 1 B GLY 237 ? B GLY 205 
83  1 Y 1 B THR 238 ? B THR 206 
84  1 Y 1 B GLN 278 ? B GLN 246 
85  1 Y 1 B VAL 279 ? B VAL 247 
86  1 Y 1 B GLU 280 ? B GLU 248 
87  1 Y 1 B GLY 281 ? B GLY 249 
88  1 Y 1 B ASP 282 ? B ASP 250 
89  1 Y 1 B ALA 283 ? B ALA 251 
90  1 Y 1 B ALA 284 ? B ALA 252 
91  1 Y 1 B GLU 285 ? B GLU 253 
92  1 Y 1 B ALA 286 ? B ALA 254 
93  1 Y 1 B PRO 287 ? B PRO 255 
94  1 Y 1 B PRO 288 ? B PRO 256 
95  1 Y 1 B ARG 289 ? B ARG 257 
96  1 Y 1 B PRO 290 ? B PRO 258 
97  1 Y 1 B ARG 291 ? B ARG 259 
98  1 Y 1 B ALA 292 ? B ALA 260 
99  1 Y 1 B PRO 293 ? B PRO 261 
100 1 Y 1 B GLY 294 ? B GLY 262 
101 1 Y 1 B ARG 295 ? B ARG 263 
102 1 Y 1 B PRO 296 ? B PRO 264 
103 1 Y 1 B LEU 297 ? B LEU 265 
104 1 Y 1 B ALA 298 ? B ALA 266 
105 1 Y 1 B SER 299 ? B SER 267 
106 1 Y 1 B TYR 300 ? B TYR 268 
107 1 Y 1 B GLY 301 ? B GLY 269 
108 1 Y 1 B MET 302 ? B MET 270 
109 1 Y 1 B ASP 303 ? B ASP 271 
110 1 Y 1 B SER 304 ? B SER 272 
111 1 Y 1 B ARG 305 ? B ARG 273 
112 1 Y 1 B PRO 306 ? B PRO 274 
113 1 Y 1 B PRO 384 ? B PRO 352 
114 1 Y 1 B SER 385 ? B SER 353 
115 1 Y 1 B THR 386 ? B THR 354 
116 1 Y 1 B ALA 387 ? B ALA 355 
117 1 Y 1 B ALA 388 ? B ALA 356 
118 1 Y 1 B ALA 389 ? B ALA 357 
119 1 Y 1 B LEU 390 ? B LEU 358 
120 1 Y 1 B GLU 391 ? B GLU 359 
121 1 Y 1 B HIS 392 ? B HIS 360 
122 1 Y 1 B HIS 393 ? B HIS 361 
123 1 Y 1 B HIS 394 ? B HIS 362 
124 1 Y 1 B HIS 395 ? B HIS 363 
125 1 Y 1 B HIS 396 ? B HIS 364 
126 1 Y 1 B HIS 397 ? B HIS 365 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
MET N    N N N 244 
MET CA   C N S 245 
MET C    C N N 246 
MET O    O N N 247 
MET CB   C N N 248 
MET CG   C N N 249 
MET SD   S N N 250 
MET CE   C N N 251 
MET OXT  O N N 252 
MET H    H N N 253 
MET H2   H N N 254 
MET HA   H N N 255 
MET HB2  H N N 256 
MET HB3  H N N 257 
MET HG2  H N N 258 
MET HG3  H N N 259 
MET HE1  H N N 260 
MET HE2  H N N 261 
MET HE3  H N N 262 
MET HXT  H N N 263 
PHE N    N N N 264 
PHE CA   C N S 265 
PHE C    C N N 266 
PHE O    O N N 267 
PHE CB   C N N 268 
PHE CG   C Y N 269 
PHE CD1  C Y N 270 
PHE CD2  C Y N 271 
PHE CE1  C Y N 272 
PHE CE2  C Y N 273 
PHE CZ   C Y N 274 
PHE OXT  O N N 275 
PHE H    H N N 276 
PHE H2   H N N 277 
PHE HA   H N N 278 
PHE HB2  H N N 279 
PHE HB3  H N N 280 
PHE HD1  H N N 281 
PHE HD2  H N N 282 
PHE HE1  H N N 283 
PHE HE2  H N N 284 
PHE HZ   H N N 285 
PHE HXT  H N N 286 
PRO N    N N N 287 
PRO CA   C N S 288 
PRO C    C N N 289 
PRO O    O N N 290 
PRO CB   C N N 291 
PRO CG   C N N 292 
PRO CD   C N N 293 
PRO OXT  O N N 294 
PRO H    H N N 295 
PRO HA   H N N 296 
PRO HB2  H N N 297 
PRO HB3  H N N 298 
PRO HG2  H N N 299 
PRO HG3  H N N 300 
PRO HD2  H N N 301 
PRO HD3  H N N 302 
PRO HXT  H N N 303 
SER N    N N N 304 
SER CA   C N S 305 
SER C    C N N 306 
SER O    O N N 307 
SER CB   C N N 308 
SER OG   O N N 309 
SER OXT  O N N 310 
SER H    H N N 311 
SER H2   H N N 312 
SER HA   H N N 313 
SER HB2  H N N 314 
SER HB3  H N N 315 
SER HG   H N N 316 
SER HXT  H N N 317 
THR N    N N N 318 
THR CA   C N S 319 
THR C    C N N 320 
THR O    O N N 321 
THR CB   C N R 322 
THR OG1  O N N 323 
THR CG2  C N N 324 
THR OXT  O N N 325 
THR H    H N N 326 
THR H2   H N N 327 
THR HA   H N N 328 
THR HB   H N N 329 
THR HG1  H N N 330 
THR HG21 H N N 331 
THR HG22 H N N 332 
THR HG23 H N N 333 
THR HXT  H N N 334 
TRP N    N N N 335 
TRP CA   C N S 336 
TRP C    C N N 337 
TRP O    O N N 338 
TRP CB   C N N 339 
TRP CG   C Y N 340 
TRP CD1  C Y N 341 
TRP CD2  C Y N 342 
TRP NE1  N Y N 343 
TRP CE2  C Y N 344 
TRP CE3  C Y N 345 
TRP CZ2  C Y N 346 
TRP CZ3  C Y N 347 
TRP CH2  C Y N 348 
TRP OXT  O N N 349 
TRP H    H N N 350 
TRP H2   H N N 351 
TRP HA   H N N 352 
TRP HB2  H N N 353 
TRP HB3  H N N 354 
TRP HD1  H N N 355 
TRP HE1  H N N 356 
TRP HE3  H N N 357 
TRP HZ2  H N N 358 
TRP HZ3  H N N 359 
TRP HH2  H N N 360 
TRP HXT  H N N 361 
TYR N    N N N 362 
TYR CA   C N S 363 
TYR C    C N N 364 
TYR O    O N N 365 
TYR CB   C N N 366 
TYR CG   C Y N 367 
TYR CD1  C Y N 368 
TYR CD2  C Y N 369 
TYR CE1  C Y N 370 
TYR CE2  C Y N 371 
TYR CZ   C Y N 372 
TYR OH   O N N 373 
TYR OXT  O N N 374 
TYR H    H N N 375 
TYR H2   H N N 376 
TYR HA   H N N 377 
TYR HB2  H N N 378 
TYR HB3  H N N 379 
TYR HD1  H N N 380 
TYR HD2  H N N 381 
TYR HE1  H N N 382 
TYR HE2  H N N 383 
TYR HH   H N N 384 
TYR HXT  H N N 385 
VAL N    N N N 386 
VAL CA   C N S 387 
VAL C    C N N 388 
VAL O    O N N 389 
VAL CB   C N N 390 
VAL CG1  C N N 391 
VAL CG2  C N N 392 
VAL OXT  O N N 393 
VAL H    H N N 394 
VAL H2   H N N 395 
VAL HA   H N N 396 
VAL HB   H N N 397 
VAL HG11 H N N 398 
VAL HG12 H N N 399 
VAL HG13 H N N 400 
VAL HG21 H N N 401 
VAL HG22 H N N 402 
VAL HG23 H N N 403 
VAL HXT  H N N 404 
WNT C3   C Y N 405 
WNT C5   C Y N 406 
WNT C6   C Y N 407 
WNT C9   C N N 408 
WNT C10  C N S 409 
WNT C11  C N S 410 
WNT C8   C N N 411 
WNT C2   C Y N 412 
WNT C7   C N N 413 
WNT C16  C N S 414 
WNT C15  C N N 415 
WNT C13  C N N 416 
WNT C12  C N N 417 
WNT C18  C N N 418 
WNT C17  C N N 419 
WNT C    C N N 420 
WNT O    O N N 421 
WNT C1   C Y N 422 
WNT C14  C N N 423 
WNT C4   C Y N 424 
WNT O1   O N N 425 
WNT O2   O N N 426 
WNT O3   O N N 427 
WNT O4   O N N 428 
WNT O5   O N N 429 
WNT O6   O N N 430 
WNT H8   H N N 431 
WNT H11  H N N 432 
WNT H12  H N N 433 
WNT H    H N N 434 
WNT H1   H N N 435 
WNT H10  H N N 436 
WNT H6   H N N 437 
WNT H9   H N N 438 
WNT H2   H N N 439 
WNT H18  H N N 440 
WNT H17  H N N 441 
WNT H15  H N N 442 
WNT H131 H N N 443 
WNT H21  H N N 444 
WNT H20  H N N 445 
WNT H19  H N N 446 
WNT H5   H N N 447 
WNT H4   H N N 448 
WNT H3   H N N 449 
WNT H16  H N N 450 
WNT H141 H N N 451 
WNT H7   H N N 452 
WNT H13  H N N 453 
WNT H14  H N N 454 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
WNT O6  C18  doub N N 389 
WNT C18 C4   sing N N 390 
WNT C18 O5   sing N N 391 
WNT C4  C3   doub Y N 392 
WNT C4  C5   sing Y N 393 
WNT C3  O1   sing N N 394 
WNT C3  C2   sing Y N 395 
WNT C2  C1   doub Y N 396 
WNT O5  C16  sing N N 397 
WNT C16 C17  sing N N 398 
WNT C16 C15  sing N N 399 
WNT C15 C14  sing N N 400 
WNT C14 C13  sing N N 401 
WNT C13 C12  sing N N 402 
WNT C12 O4   doub N N 403 
WNT C12 C11  sing N N 404 
WNT C11 O3   sing N N 405 
WNT C11 C10  sing N N 406 
WNT C10 O2   sing N N 407 
WNT C10 C9   sing N N 408 
WNT C9  C8   sing N N 409 
WNT C8  C7   doub N E 410 
WNT C7  C5   sing N N 411 
WNT C5  C6   doub Y N 412 
WNT C6  C1   sing Y N 413 
WNT C1  O    sing N N 414 
WNT O   C    sing N N 415 
WNT C6  H8   sing N N 416 
WNT C9  H11  sing N N 417 
WNT C9  H12  sing N N 418 
WNT C10 H    sing N N 419 
WNT C11 H1   sing N N 420 
WNT C8  H10  sing N N 421 
WNT C2  H6   sing N N 422 
WNT C7  H9   sing N N 423 
WNT C16 H2   sing N N 424 
WNT C15 H18  sing N N 425 
WNT C15 H17  sing N N 426 
WNT C13 H15  sing N N 427 
WNT C13 H131 sing N N 428 
WNT C17 H21  sing N N 429 
WNT C17 H20  sing N N 430 
WNT C17 H19  sing N N 431 
WNT C   H5   sing N N 432 
WNT C   H4   sing N N 433 
WNT C   H3   sing N N 434 
WNT C14 H16  sing N N 435 
WNT C14 H141 sing N N 436 
WNT O1  H7   sing N N 437 
WNT O2  H13  sing N N 438 
WNT O3  H14  sing N N 439 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5HZE 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YP4 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021113 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001794 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007755 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015278 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 0.8669   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . GLN A 1 2   ? 8.928   -16.140 -4.211 1.00 182.77 ? 34  GLN A N   1 ? 
ATOM   2    C CA  . GLN A 1 2   ? 10.333  -16.600 -4.389 1.00 184.11 ? 34  GLN A CA  1 ? 
ATOM   3    C C   . GLN A 1 2   ? 11.219  -15.897 -3.356 1.00 190.66 ? 34  GLN A C   1 ? 
ATOM   4    O O   . GLN A 1 2   ? 10.842  -15.813 -2.188 1.00 187.22 ? 34  GLN A O   1 ? 
ATOM   5    C CB  . GLN A 1 2   ? 10.743  -16.416 -5.853 1.00 181.93 ? 34  GLN A CB  1 ? 
ATOM   6    C CG  . GLN A 1 2   ? 10.706  -14.975 -6.353 1.00 181.79 ? 34  GLN A CG  1 ? 
ATOM   7    C CD  . GLN A 1 2   ? 11.778  -14.694 -7.382 1.00 179.91 ? 34  GLN A CD  1 ? 
ATOM   8    O OE1 . GLN A 1 2   ? 11.923  -15.428 -8.366 1.00 165.41 ? 34  GLN A OE1 1 ? 
ATOM   9    N NE2 . GLN A 1 2   ? 12.559  -13.648 -7.151 1.00 186.85 ? 34  GLN A NE2 1 ? 
ATOM   10   N N   . LYS A 1 3   ? 12.393  -15.405 -3.785 1.00 196.86 ? 35  LYS A N   1 ? 
ATOM   11   C CA  . LYS A 1 3   ? 13.301  -14.663 -2.921 1.00 194.06 ? 35  LYS A CA  1 ? 
ATOM   12   C C   . LYS A 1 3   ? 13.168  -13.167 -3.214 1.00 195.99 ? 35  LYS A C   1 ? 
ATOM   13   O O   . LYS A 1 3   ? 14.157  -12.437 -3.182 1.00 194.66 ? 35  LYS A O   1 ? 
ATOM   14   C CB  . LYS A 1 3   ? 14.751  -15.120 -3.146 1.00 186.82 ? 35  LYS A CB  1 ? 
ATOM   15   C CG  . LYS A 1 3   ? 15.511  -15.541 -1.892 1.00 188.21 ? 35  LYS A CG  1 ? 
ATOM   16   C CD  . LYS A 1 3   ? 16.871  -14.880 -1.700 1.00 188.75 ? 35  LYS A CD  1 ? 
ATOM   17   C CE  . LYS A 1 3   ? 16.753  -13.455 -1.248 1.00 193.30 ? 35  LYS A CE  1 ? 
ATOM   18   N NZ  . LYS A 1 3   ? 15.956  -13.300 -0.026 1.00 195.92 ? 35  LYS A NZ  1 ? 
ATOM   19   N N   . LYS A 1 4   ? 11.935  -12.715 -3.488 1.00 199.56 ? 36  LYS A N   1 ? 
ATOM   20   C CA  . LYS A 1 4   ? 11.675  -11.340 -3.892 1.00 199.45 ? 36  LYS A CA  1 ? 
ATOM   21   C C   . LYS A 1 4   ? 12.100  -10.396 -2.768 1.00 204.10 ? 36  LYS A C   1 ? 
ATOM   22   O O   . LYS A 1 4   ? 13.017  -9.598  -2.952 1.00 205.43 ? 36  LYS A O   1 ? 
ATOM   23   C CB  . LYS A 1 4   ? 10.206  -11.183 -4.316 1.00 192.42 ? 36  LYS A CB  1 ? 
ATOM   24   C CG  . LYS A 1 4   ? 9.709   -9.764  -4.600 1.00 185.64 ? 36  LYS A CG  1 ? 
ATOM   25   C CD  . LYS A 1 4   ? 10.494  -8.925  -5.607 1.00 184.08 ? 36  LYS A CD  1 ? 
ATOM   26   C CE  . LYS A 1 4   ? 10.319  -9.298  -7.051 1.00 176.69 ? 36  LYS A CE  1 ? 
ATOM   27   N NZ  . LYS A 1 4   ? 11.273  -10.309 -7.511 1.00 170.99 ? 36  LYS A NZ  1 ? 
ATOM   28   N N   . LEU A 1 5   ? 11.448  -10.522 -1.603 1.00 204.15 ? 37  LEU A N   1 ? 
ATOM   29   C CA  . LEU A 1 5   ? 11.692  -9.663  -0.451 1.00 198.78 ? 37  LEU A CA  1 ? 
ATOM   30   C C   . LEU A 1 5   ? 11.723  -8.203  -0.896 1.00 202.43 ? 37  LEU A C   1 ? 
ATOM   31   O O   . LEU A 1 5   ? 12.789  -7.588  -0.904 1.00 206.30 ? 37  LEU A O   1 ? 
ATOM   32   C CB  . LEU A 1 5   ? 12.994  -10.014 0.277  1.00 190.96 ? 37  LEU A CB  1 ? 
ATOM   33   C CG  . LEU A 1 5   ? 13.007  -11.263 1.167  1.00 190.86 ? 37  LEU A CG  1 ? 
ATOM   34   C CD1 . LEU A 1 5   ? 14.140  -11.109 2.175  1.00 185.66 ? 37  LEU A CD1 1 ? 
ATOM   35   C CD2 . LEU A 1 5   ? 11.698  -11.552 1.886  1.00 188.29 ? 37  LEU A CD2 1 ? 
ATOM   36   N N   . GLU A 1 6   ? 10.559  -7.645  -1.258 1.00 200.02 ? 38  GLU A N   1 ? 
ATOM   37   C CA  . GLU A 1 6   ? 10.523  -6.269  -1.730 1.00 190.27 ? 38  GLU A CA  1 ? 
ATOM   38   C C   . GLU A 1 6   ? 9.234   -5.569  -1.298 1.00 184.88 ? 38  GLU A C   1 ? 
ATOM   39   O O   . GLU A 1 6   ? 8.136   -6.019  -1.623 1.00 178.14 ? 38  GLU A O   1 ? 
ATOM   40   C CB  . GLU A 1 6   ? 10.727  -6.211  -3.245 1.00 177.43 ? 38  GLU A CB  1 ? 
ATOM   41   C CG  . GLU A 1 6   ? 11.219  -4.854  -3.745 1.00 172.35 ? 38  GLU A CG  1 ? 
ATOM   42   C CD  . GLU A 1 6   ? 12.345  -4.220  -2.941 1.00 175.43 ? 38  GLU A CD  1 ? 
ATOM   43   O OE1 . GLU A 1 6   ? 13.497  -4.249  -3.421 1.00 181.79 ? 38  GLU A OE1 1 ? 
ATOM   44   O OE2 . GLU A 1 6   ? 12.077  -3.673  -1.849 1.00 170.68 ? 38  GLU A OE2 1 ? 
ATOM   45   N N   . GLU A 1 7   ? 9.408   -4.461  -0.561 1.00 174.41 ? 39  GLU A N   1 ? 
ATOM   46   C CA  . GLU A 1 7   ? 8.330   -3.553  -0.195 1.00 163.91 ? 39  GLU A CA  1 ? 
ATOM   47   C C   . GLU A 1 7   ? 8.855   -2.113  -0.282 1.00 165.90 ? 39  GLU A C   1 ? 
ATOM   48   O O   . GLU A 1 7   ? 8.840   -1.535  -1.367 1.00 144.17 ? 39  GLU A O   1 ? 
ATOM   49   C CB  . GLU A 1 7   ? 7.738   -3.991  1.148  1.00 159.26 ? 39  GLU A CB  1 ? 
ATOM   50   C CG  . GLU A 1 7   ? 6.756   -5.163  1.061  1.00 161.84 ? 39  GLU A CG  1 ? 
ATOM   51   C CD  . GLU A 1 7   ? 7.287   -6.586  1.194  1.00 163.37 ? 39  GLU A CD  1 ? 
ATOM   52   O OE1 . GLU A 1 7   ? 8.513   -6.789  1.328  1.00 160.65 ? 39  GLU A OE1 1 ? 
ATOM   53   O OE2 . GLU A 1 7   ? 6.447   -7.515  1.174  1.00 153.60 ? 39  GLU A OE2 1 ? 
ATOM   54   N N   . LEU A 1 8   ? 9.311   -1.539  0.847  1.00 177.56 ? 40  LEU A N   1 ? 
ATOM   55   C CA  . LEU A 1 8   ? 9.985   -0.240  0.887  1.00 186.43 ? 40  LEU A CA  1 ? 
ATOM   56   C C   . LEU A 1 8   ? 10.217  0.135   2.357  1.00 189.47 ? 40  LEU A C   1 ? 
ATOM   57   O O   . LEU A 1 8   ? 10.082  -0.714  3.237  1.00 188.64 ? 40  LEU A O   1 ? 
ATOM   58   C CB  . LEU A 1 8   ? 9.206   0.847   0.133  1.00 195.24 ? 40  LEU A CB  1 ? 
ATOM   59   C CG  . LEU A 1 8   ? 10.009  1.752   -0.816 1.00 191.67 ? 40  LEU A CG  1 ? 
ATOM   60   C CD1 . LEU A 1 8   ? 9.219   2.019   -2.092 1.00 190.75 ? 40  LEU A CD1 1 ? 
ATOM   61   C CD2 . LEU A 1 8   ? 10.413  3.092   -0.215 1.00 184.14 ? 40  LEU A CD2 1 ? 
ATOM   62   N N   . GLU A 1 9   ? 10.599  1.398   2.613  1.00 187.96 ? 41  GLU A N   1 ? 
ATOM   63   C CA  . GLU A 1 9   ? 10.650  1.958   3.959  1.00 175.59 ? 41  GLU A CA  1 ? 
ATOM   64   C C   . GLU A 1 9   ? 9.228   2.043   4.512  1.00 169.15 ? 41  GLU A C   1 ? 
ATOM   65   O O   . GLU A 1 9   ? 8.989   1.675   5.662  1.00 166.41 ? 41  GLU A O   1 ? 
ATOM   66   C CB  . GLU A 1 9   ? 11.332  3.332   3.955  1.00 168.00 ? 41  GLU A CB  1 ? 
ATOM   67   C CG  . GLU A 1 9   ? 11.922  3.760   5.299  1.00 160.61 ? 41  GLU A CG  1 ? 
ATOM   68   C CD  . GLU A 1 9   ? 10.970  4.310   6.350  1.00 149.20 ? 41  GLU A CD  1 ? 
ATOM   69   O OE1 . GLU A 1 9   ? 11.458  4.635   7.453  1.00 137.59 ? 41  GLU A OE1 1 ? 
ATOM   70   O OE2 . GLU A 1 9   ? 9.758   4.431   6.084  1.00 137.90 ? 41  GLU A OE2 1 ? 
ATOM   71   N N   . LEU A 1 10  ? 8.301   2.533   3.672  1.00 158.43 ? 42  LEU A N   1 ? 
ATOM   72   C CA  . LEU A 1 10  ? 6.879   2.592   3.985  1.00 144.79 ? 42  LEU A CA  1 ? 
ATOM   73   C C   . LEU A 1 10  ? 6.091   1.982   2.825  1.00 128.89 ? 42  LEU A C   1 ? 
ATOM   74   O O   . LEU A 1 10  ? 5.525   2.695   1.996  1.00 114.83 ? 42  LEU A O   1 ? 
ATOM   75   C CB  . LEU A 1 10  ? 6.427   4.015   4.328  1.00 151.80 ? 42  LEU A CB  1 ? 
ATOM   76   C CG  . LEU A 1 10  ? 7.283   5.168   3.788  1.00 162.96 ? 42  LEU A CG  1 ? 
ATOM   77   C CD1 . LEU A 1 10  ? 6.969   5.515   2.338  1.00 161.72 ? 42  LEU A CD1 1 ? 
ATOM   78   C CD2 . LEU A 1 10  ? 7.148   6.395   4.682  1.00 160.62 ? 42  LEU A CD2 1 ? 
ATOM   79   N N   . ASP A 1 11  ? 6.076   0.641   2.801  1.00 119.63 ? 43  ASP A N   1 ? 
ATOM   80   C CA  . ASP A 1 11  ? 5.336   -0.145  1.826  1.00 116.71 ? 43  ASP A CA  1 ? 
ATOM   81   C C   . ASP A 1 11  ? 4.155   0.673   1.310  1.00 115.24 ? 43  ASP A C   1 ? 
ATOM   82   O O   . ASP A 1 11  ? 3.188   0.884   2.032  1.00 137.87 ? 43  ASP A O   1 ? 
ATOM   83   C CB  . ASP A 1 11  ? 4.903   -1.480  2.416  1.00 117.37 ? 43  ASP A CB  1 ? 
ATOM   84   C CG  . ASP A 1 11  ? 4.078   -2.368  1.493  1.00 129.21 ? 43  ASP A CG  1 ? 
ATOM   85   O OD1 . ASP A 1 11  ? 4.571   -2.689  0.389  1.00 131.57 ? 43  ASP A OD1 1 ? 
ATOM   86   O OD2 . ASP A 1 11  ? 2.945   -2.728  1.881  1.00 130.18 ? 43  ASP A OD2 1 ? 
ATOM   87   N N   . GLU A 1 12  ? 4.255   1.126   0.056  1.00 103.31 ? 44  GLU A N   1 ? 
ATOM   88   C CA  . GLU A 1 12  ? 3.274   2.001   -0.573 1.00 103.05 ? 44  GLU A CA  1 ? 
ATOM   89   C C   . GLU A 1 12  ? 1.852   1.800   -0.046 1.00 93.57  ? 44  GLU A C   1 ? 
ATOM   90   O O   . GLU A 1 12  ? 1.097   2.766   -0.004 1.00 88.24  ? 44  GLU A O   1 ? 
ATOM   91   C CB  . GLU A 1 12  ? 3.309   1.860   -2.096 1.00 114.12 ? 44  GLU A CB  1 ? 
ATOM   92   C CG  . GLU A 1 12  ? 4.120   2.952   -2.794 1.00 125.84 ? 44  GLU A CG  1 ? 
ATOM   93   C CD  . GLU A 1 12  ? 5.404   3.388   -2.098 1.00 133.44 ? 44  GLU A CD  1 ? 
ATOM   94   O OE1 . GLU A 1 12  ? 5.624   4.609   -1.922 1.00 117.99 ? 44  GLU A OE1 1 ? 
ATOM   95   O OE2 . GLU A 1 12  ? 6.182   2.494   -1.709 1.00 146.12 ? 44  GLU A OE2 1 ? 
ATOM   96   N N   . GLN A 1 13  ? 1.471   0.572   0.329  1.00 93.04  ? 45  GLN A N   1 ? 
ATOM   97   C CA  . GLN A 1 13  ? 0.158   0.340   0.916  1.00 92.19  ? 45  GLN A CA  1 ? 
ATOM   98   C C   . GLN A 1 13  ? 0.004   1.165   2.199  1.00 86.53  ? 45  GLN A C   1 ? 
ATOM   99   O O   . GLN A 1 13  ? -0.958  1.917   2.343  1.00 85.05  ? 45  GLN A O   1 ? 
ATOM   100  C CB  . GLN A 1 13  ? -0.060  -1.153  1.145  1.00 101.62 ? 45  GLN A CB  1 ? 
ATOM   101  C CG  . GLN A 1 13  ? -1.483  -1.513  1.556  1.00 113.18 ? 45  GLN A CG  1 ? 
ATOM   102  C CD  . GLN A 1 13  ? -1.642  -2.977  1.905  1.00 124.76 ? 45  GLN A CD  1 ? 
ATOM   103  O OE1 . GLN A 1 13  ? -1.791  -3.349  3.075  1.00 136.51 ? 45  GLN A OE1 1 ? 
ATOM   104  N NE2 . GLN A 1 13  ? -1.591  -3.831  0.892  1.00 126.60 ? 45  GLN A NE2 1 ? 
ATOM   105  N N   . GLN A 1 14  ? 0.970   1.021   3.116  1.00 79.09  ? 46  GLN A N   1 ? 
ATOM   106  C CA  . GLN A 1 14  ? 1.050   1.804   4.341  1.00 76.35  ? 46  GLN A CA  1 ? 
ATOM   107  C C   . GLN A 1 14  ? 0.938   3.296   4.034  1.00 76.96  ? 46  GLN A C   1 ? 
ATOM   108  O O   . GLN A 1 14  ? 0.149   4.009   4.651  1.00 80.66  ? 46  GLN A O   1 ? 
ATOM   109  C CB  . GLN A 1 14  ? 2.387   1.634   5.072  1.00 72.06  ? 46  GLN A CB  1 ? 
ATOM   110  C CG  . GLN A 1 14  ? 2.655   0.246   5.641  1.00 70.91  ? 46  GLN A CG  1 ? 
ATOM   111  C CD  . GLN A 1 14  ? 3.862   0.218   6.556  1.00 74.65  ? 46  GLN A CD  1 ? 
ATOM   112  O OE1 . GLN A 1 14  ? 4.912   0.790   6.242  1.00 82.72  ? 46  GLN A OE1 1 ? 
ATOM   113  N NE2 . GLN A 1 14  ? 3.728   -0.421  7.713  1.00 77.62  ? 46  GLN A NE2 1 ? 
ATOM   114  N N   . ARG A 1 15  ? 1.773   3.757   3.099  1.00 81.15  ? 47  ARG A N   1 ? 
ATOM   115  C CA  . ARG A 1 15  ? 1.797   5.144   2.669  1.00 83.56  ? 47  ARG A CA  1 ? 
ATOM   116  C C   . ARG A 1 15  ? 0.412   5.562   2.163  1.00 79.01  ? 47  ARG A C   1 ? 
ATOM   117  O O   . ARG A 1 15  ? -0.060  6.634   2.514  1.00 76.76  ? 47  ARG A O   1 ? 
ATOM   118  C CB  . ARG A 1 15  ? 2.900   5.262   1.609  1.00 98.86  ? 47  ARG A CB  1 ? 
ATOM   119  C CG  . ARG A 1 15  ? 3.451   6.655   1.332  1.00 111.62 ? 47  ARG A CG  1 ? 
ATOM   120  C CD  . ARG A 1 15  ? 4.240   6.717   0.021  1.00 125.44 ? 47  ARG A CD  1 ? 
ATOM   121  N NE  . ARG A 1 15  ? 3.387   6.447   -1.147 1.00 137.92 ? 47  ARG A NE  1 ? 
ATOM   122  C CZ  . ARG A 1 15  ? 3.075   7.292   -2.129 1.00 137.48 ? 47  ARG A CZ  1 ? 
ATOM   123  N NH1 . ARG A 1 15  ? 2.093   6.996   -2.966 1.00 125.53 ? 47  ARG A NH1 1 ? 
ATOM   124  N NH2 . ARG A 1 15  ? 3.690   8.457   -2.234 1.00 144.31 ? 47  ARG A NH2 1 ? 
ATOM   125  N N   . LYS A 1 16  ? -0.244  4.713   1.358  1.00 80.41  ? 48  LYS A N   1 ? 
ATOM   126  C CA  . LYS A 1 16  ? -1.573  4.996   0.831  1.00 89.11  ? 48  LYS A CA  1 ? 
ATOM   127  C C   . LYS A 1 16  ? -2.610  5.058   1.949  1.00 91.16  ? 48  LYS A C   1 ? 
ATOM   128  O O   . LYS A 1 16  ? -3.529  5.872   1.904  1.00 101.12 ? 48  LYS A O   1 ? 
ATOM   129  C CB  . LYS A 1 16  ? -2.078  3.949   -0.170 1.00 95.62  ? 48  LYS A CB  1 ? 
ATOM   130  C CG  . LYS A 1 16  ? -1.954  4.311   -1.637 1.00 104.01 ? 48  LYS A CG  1 ? 
ATOM   131  C CD  . LYS A 1 16  ? -0.537  4.567   -2.132 1.00 115.62 ? 48  LYS A CD  1 ? 
ATOM   132  C CE  . LYS A 1 16  ? -0.483  4.805   -3.616 1.00 126.79 ? 48  LYS A CE  1 ? 
ATOM   133  N NZ  . LYS A 1 16  ? -0.871  3.628   -4.400 1.00 126.63 ? 48  LYS A NZ  1 ? 
ATOM   134  N N   . ARG A 1 17  ? -2.501  4.162   2.928  1.00 86.76  ? 49  ARG A N   1 ? 
ATOM   135  C CA  . ARG A 1 17  ? -3.516  4.103   3.965  1.00 85.55  ? 49  ARG A CA  1 ? 
ATOM   136  C C   . ARG A 1 17  ? -3.429  5.368   4.814  1.00 77.81  ? 49  ARG A C   1 ? 
ATOM   137  O O   . ARG A 1 17  ? -4.463  5.883   5.230  1.00 77.81  ? 49  ARG A O   1 ? 
ATOM   138  C CB  . ARG A 1 17  ? -3.417  2.802   4.770  1.00 87.16  ? 49  ARG A CB  1 ? 
ATOM   139  C CG  . ARG A 1 17  ? -4.029  1.598   4.067  1.00 86.43  ? 49  ARG A CG  1 ? 
ATOM   140  C CD  . ARG A 1 17  ? -3.466  0.301   4.626  1.00 97.01  ? 49  ARG A CD  1 ? 
ATOM   141  N NE  . ARG A 1 17  ? -4.220  -0.911  4.280  1.00 106.33 ? 49  ARG A NE  1 ? 
ATOM   142  C CZ  . ARG A 1 17  ? -3.939  -2.128  4.751  1.00 97.68  ? 49  ARG A CZ  1 ? 
ATOM   143  N NH1 . ARG A 1 17  ? -2.856  -2.329  5.485  1.00 94.41  ? 49  ARG A NH1 1 ? 
ATOM   144  N NH2 . ARG A 1 17  ? -4.738  -3.144  4.477  1.00 96.61  ? 49  ARG A NH2 1 ? 
ATOM   145  N N   . LEU A 1 18  ? -2.200  5.872   5.023  1.00 75.07  ? 50  LEU A N   1 ? 
ATOM   146  C CA  . LEU A 1 18  ? -1.953  7.107   5.764  1.00 75.54  ? 50  LEU A CA  1 ? 
ATOM   147  C C   . LEU A 1 18  ? -2.549  8.319   5.046  1.00 73.87  ? 50  LEU A C   1 ? 
ATOM   148  O O   . LEU A 1 18  ? -2.891  9.311   5.696  1.00 78.03  ? 50  LEU A O   1 ? 
ATOM   149  C CB  . LEU A 1 18  ? -0.461  7.354   6.002  1.00 68.83  ? 50  LEU A CB  1 ? 
ATOM   150  C CG  . LEU A 1 18  ? 0.166   6.716   7.246  1.00 76.03  ? 50  LEU A CG  1 ? 
ATOM   151  C CD1 . LEU A 1 18  ? 1.615   7.181   7.410  1.00 77.20  ? 50  LEU A CD1 1 ? 
ATOM   152  C CD2 . LEU A 1 18  ? -0.610  7.013   8.518  1.00 76.09  ? 50  LEU A CD2 1 ? 
ATOM   153  N N   . GLU A 1 19  ? -2.607  8.259   3.712  1.00 71.40  ? 51  GLU A N   1 ? 
ATOM   154  C CA  . GLU A 1 19  ? -3.056  9.387   2.911  1.00 75.23  ? 51  GLU A CA  1 ? 
ATOM   155  C C   . GLU A 1 19  ? -4.578  9.409   2.945  1.00 70.20  ? 51  GLU A C   1 ? 
ATOM   156  O O   . GLU A 1 19  ? -5.190  10.427  3.268  1.00 77.75  ? 51  GLU A O   1 ? 
ATOM   157  C CB  . GLU A 1 19  ? -2.467  9.271   1.504  1.00 84.63  ? 51  GLU A CB  1 ? 
ATOM   158  C CG  . GLU A 1 19  ? -0.981  9.626   1.447  1.00 91.03  ? 51  GLU A CG  1 ? 
ATOM   159  C CD  . GLU A 1 19  ? -0.254  9.259   0.159  1.00 96.56  ? 51  GLU A CD  1 ? 
ATOM   160  O OE1 . GLU A 1 19  ? -0.813  8.522   -0.683 1.00 101.07 ? 51  GLU A OE1 1 ? 
ATOM   161  O OE2 . GLU A 1 19  ? 0.894   9.722   -0.003 1.00 97.22  ? 51  GLU A OE2 1 ? 
ATOM   162  N N   . ALA A 1 20  ? -5.159  8.245   2.655  1.00 68.22  ? 52  ALA A N   1 ? 
ATOM   163  C CA  . ALA A 1 20  ? -6.590  8.008   2.757  1.00 71.65  ? 52  ALA A CA  1 ? 
ATOM   164  C C   . ALA A 1 20  ? -7.147  8.504   4.089  1.00 74.05  ? 52  ALA A C   1 ? 
ATOM   165  O O   . ALA A 1 20  ? -8.214  9.117   4.135  1.00 74.79  ? 52  ALA A O   1 ? 
ATOM   166  C CB  . ALA A 1 20  ? -6.849  6.532   2.593  1.00 73.02  ? 52  ALA A CB  1 ? 
ATOM   167  N N   . PHE A 1 21  ? -6.432  8.205   5.176  1.00 72.07  ? 53  PHE A N   1 ? 
ATOM   168  C CA  . PHE A 1 21  ? -6.917  8.550   6.502  1.00 77.38  ? 53  PHE A CA  1 ? 
ATOM   169  C C   . PHE A 1 21  ? -6.906  10.070  6.640  1.00 78.65  ? 53  PHE A C   1 ? 
ATOM   170  O O   . PHE A 1 21  ? -7.893  10.658  7.083  1.00 82.42  ? 53  PHE A O   1 ? 
ATOM   171  C CB  . PHE A 1 21  ? -6.121  7.852   7.613  1.00 68.11  ? 53  PHE A CB  1 ? 
ATOM   172  C CG  . PHE A 1 21  ? -6.635  8.185   9.006  1.00 71.07  ? 53  PHE A CG  1 ? 
ATOM   173  C CD1 . PHE A 1 21  ? -7.748  7.526   9.529  1.00 77.43  ? 53  PHE A CD1 1 ? 
ATOM   174  C CD2 . PHE A 1 21  ? -6.019  9.164   9.780  1.00 72.34  ? 53  PHE A CD2 1 ? 
ATOM   175  C CE1 . PHE A 1 21  ? -8.228  7.832   10.794 1.00 74.19  ? 53  PHE A CE1 1 ? 
ATOM   176  C CE2 . PHE A 1 21  ? -6.494  9.463   11.049 1.00 80.89  ? 53  PHE A CE2 1 ? 
ATOM   177  C CZ  . PHE A 1 21  ? -7.600  8.798   11.552 1.00 82.86  ? 53  PHE A CZ  1 ? 
ATOM   178  N N   . LEU A 1 22  ? -5.780  10.685  6.258  1.00 78.43  ? 54  LEU A N   1 ? 
ATOM   179  C CA  . LEU A 1 22  ? -5.640  12.135  6.242  1.00 74.95  ? 54  LEU A CA  1 ? 
ATOM   180  C C   . LEU A 1 22  ? -6.832  12.773  5.524  1.00 77.39  ? 54  LEU A C   1 ? 
ATOM   181  O O   . LEU A 1 22  ? -7.477  13.665  6.075  1.00 66.72  ? 54  LEU A O   1 ? 
ATOM   182  C CB  . LEU A 1 22  ? -4.331  12.494  5.539  1.00 76.61  ? 54  LEU A CB  1 ? 
ATOM   183  C CG  . LEU A 1 22  ? -3.653  13.813  5.930  1.00 75.30  ? 54  LEU A CG  1 ? 
ATOM   184  C CD1 . LEU A 1 22  ? -3.147  14.463  4.655  1.00 76.39  ? 54  LEU A CD1 1 ? 
ATOM   185  C CD2 . LEU A 1 22  ? -4.481  14.800  6.725  1.00 76.62  ? 54  LEU A CD2 1 ? 
ATOM   186  N N   . THR A 1 23  ? -7.123  12.325  4.290  1.00 72.53  ? 55  THR A N   1 ? 
ATOM   187  C CA  . THR A 1 23  ? -8.186  12.938  3.504  1.00 75.84  ? 55  THR A CA  1 ? 
ATOM   188  C C   . THR A 1 23  ? -9.510  12.862  4.271  1.00 79.02  ? 55  THR A C   1 ? 
ATOM   189  O O   . THR A 1 23  ? -10.215 13.865  4.370  1.00 75.24  ? 55  THR A O   1 ? 
ATOM   190  C CB  . THR A 1 23  ? -8.285  12.292  2.123  1.00 71.01  ? 55  THR A CB  1 ? 
ATOM   191  O OG1 . THR A 1 23  ? -7.118  12.693  1.420  1.00 70.52  ? 55  THR A OG1 1 ? 
ATOM   192  C CG2 . THR A 1 23  ? -9.469  12.797  1.325  1.00 70.69  ? 55  THR A CG2 1 ? 
ATOM   193  N N   . GLN A 1 24  ? -9.827  11.670  4.803  1.00 84.21  ? 56  GLN A N   1 ? 
ATOM   194  C CA  . GLN A 1 24  ? -11.073 11.399  5.512  1.00 74.65  ? 56  GLN A CA  1 ? 
ATOM   195  C C   . GLN A 1 24  ? -11.180 12.252  6.768  1.00 64.26  ? 56  GLN A C   1 ? 
ATOM   196  O O   . GLN A 1 24  ? -12.232 12.818  7.047  1.00 73.30  ? 56  GLN A O   1 ? 
ATOM   197  C CB  . GLN A 1 24  ? -11.171 9.948   5.977  1.00 82.55  ? 56  GLN A CB  1 ? 
ATOM   198  C CG  . GLN A 1 24  ? -11.479 8.957   4.863  1.00 99.35  ? 56  GLN A CG  1 ? 
ATOM   199  C CD  . GLN A 1 24  ? -11.754 7.568   5.391  1.00 109.71 ? 56  GLN A CD  1 ? 
ATOM   200  O OE1 . GLN A 1 24  ? -12.869 7.263   5.830  1.00 113.49 ? 56  GLN A OE1 1 ? 
ATOM   201  N NE2 . GLN A 1 24  ? -10.738 6.716   5.351  1.00 107.73 ? 56  GLN A NE2 1 ? 
ATOM   202  N N   . LYS A 1 25  ? -10.085 12.340  7.523  1.00 65.02  ? 57  LYS A N   1 ? 
ATOM   203  C CA  . LYS A 1 25  ? -10.028 13.200  8.696  1.00 68.42  ? 57  LYS A CA  1 ? 
ATOM   204  C C   . LYS A 1 25  ? -10.424 14.625  8.304  1.00 73.32  ? 57  LYS A C   1 ? 
ATOM   205  O O   . LYS A 1 25  ? -11.045 15.335  9.090  1.00 86.32  ? 57  LYS A O   1 ? 
ATOM   206  C CB  . LYS A 1 25  ? -8.641  13.115  9.353  1.00 66.02  ? 57  LYS A CB  1 ? 
ATOM   207  C CG  . LYS A 1 25  ? -8.311  14.218  10.357 1.00 78.50  ? 57  LYS A CG  1 ? 
ATOM   208  C CD  . LYS A 1 25  ? -7.038  14.029  11.178 1.00 85.25  ? 57  LYS A CD  1 ? 
ATOM   209  C CE  . LYS A 1 25  ? -5.749  14.100  10.402 1.00 96.34  ? 57  LYS A CE  1 ? 
ATOM   210  N NZ  . LYS A 1 25  ? -4.550  13.866  11.221 1.00 97.14  ? 57  LYS A NZ  1 ? 
ATOM   211  N N   . GLN A 1 26  ? -10.084 15.037  7.078  1.00 85.20  ? 58  GLN A N   1 ? 
ATOM   212  C CA  . GLN A 1 26  ? -10.274 16.420  6.662  1.00 86.51  ? 58  GLN A CA  1 ? 
ATOM   213  C C   . GLN A 1 26  ? -11.732 16.670  6.278  1.00 88.75  ? 58  GLN A C   1 ? 
ATOM   214  O O   . GLN A 1 26  ? -12.266 17.738  6.580  1.00 84.62  ? 58  GLN A O   1 ? 
ATOM   215  C CB  . GLN A 1 26  ? -9.258  16.782  5.576  1.00 80.10  ? 58  GLN A CB  1 ? 
ATOM   216  C CG  . GLN A 1 26  ? -7.837  16.962  6.107  1.00 76.03  ? 58  GLN A CG  1 ? 
ATOM   217  C CD  . GLN A 1 26  ? -6.787  17.158  5.030  1.00 74.83  ? 58  GLN A CD  1 ? 
ATOM   218  O OE1 . GLN A 1 26  ? -5.798  17.881  5.219  1.00 69.89  ? 58  GLN A OE1 1 ? 
ATOM   219  N NE2 . GLN A 1 26  ? -6.952  16.473  3.906  1.00 67.10  ? 58  GLN A NE2 1 ? 
ATOM   220  N N   . LYS A 1 27  ? -12.381 15.672  5.660  1.00 84.31  ? 59  LYS A N   1 ? 
ATOM   221  C CA  . LYS A 1 27  ? -13.751 15.823  5.187  1.00 86.15  ? 59  LYS A CA  1 ? 
ATOM   222  C C   . LYS A 1 27  ? -14.768 15.632  6.311  1.00 86.96  ? 59  LYS A C   1 ? 
ATOM   223  O O   . LYS A 1 27  ? -15.966 15.681  6.059  1.00 99.22  ? 59  LYS A O   1 ? 
ATOM   224  C CB  . LYS A 1 27  ? -14.072 14.815  4.082  1.00 76.67  ? 59  LYS A CB  1 ? 
ATOM   225  C CG  . LYS A 1 27  ? -13.089 14.848  2.935  1.00 81.78  ? 59  LYS A CG  1 ? 
ATOM   226  C CD  . LYS A 1 27  ? -12.881 13.507  2.249  1.00 85.65  ? 59  LYS A CD  1 ? 
ATOM   227  C CE  . LYS A 1 27  ? -14.140 12.908  1.697  1.00 95.05  ? 59  LYS A CE  1 ? 
ATOM   228  N NZ  . LYS A 1 27  ? -14.536 13.446  0.393  1.00 93.47  ? 59  LYS A NZ  1 ? 
ATOM   229  N N   . VAL A 1 28  ? -14.299 15.402  7.540  1.00 91.78  ? 60  VAL A N   1 ? 
ATOM   230  C CA  . VAL A 1 28  ? -15.190 15.256  8.679  1.00 92.72  ? 60  VAL A CA  1 ? 
ATOM   231  C C   . VAL A 1 28  ? -15.611 16.643  9.158  1.00 95.77  ? 60  VAL A C   1 ? 
ATOM   232  O O   . VAL A 1 28  ? -16.758 16.856  9.545  1.00 93.07  ? 60  VAL A O   1 ? 
ATOM   233  C CB  . VAL A 1 28  ? -14.507 14.424  9.783  1.00 86.54  ? 60  VAL A CB  1 ? 
ATOM   234  C CG1 . VAL A 1 28  ? -15.134 14.631  11.156 1.00 94.22  ? 60  VAL A CG1 1 ? 
ATOM   235  C CG2 . VAL A 1 28  ? -14.496 12.944  9.428  1.00 81.19  ? 60  VAL A CG2 1 ? 
ATOM   236  N N   . GLY A 1 29  ? -14.662 17.579  9.139  1.00 101.34 ? 61  GLY A N   1 ? 
ATOM   237  C CA  . GLY A 1 29  ? -14.946 18.949  9.520  1.00 113.81 ? 61  GLY A CA  1 ? 
ATOM   238  C C   . GLY A 1 29  ? -15.024 19.080  11.036 1.00 118.31 ? 61  GLY A C   1 ? 
ATOM   239  O O   . GLY A 1 29  ? -14.254 18.444  11.751 1.00 119.79 ? 61  GLY A O   1 ? 
ATOM   240  N N   . GLU A 1 30  ? -15.974 19.895  11.503 1.00 123.91 ? 62  GLU A N   1 ? 
ATOM   241  C CA  . GLU A 1 30  ? -16.069 20.238  12.912 1.00 127.64 ? 62  GLU A CA  1 ? 
ATOM   242  C C   . GLU A 1 30  ? -16.683 19.055  13.661 1.00 119.32 ? 62  GLU A C   1 ? 
ATOM   243  O O   . GLU A 1 30  ? -17.516 18.332  13.113 1.00 109.86 ? 62  GLU A O   1 ? 
ATOM   244  C CB  . GLU A 1 30  ? -16.849 21.547  13.059 1.00 140.70 ? 62  GLU A CB  1 ? 
ATOM   245  C CG  . GLU A 1 30  ? -16.324 22.459  14.167 1.00 147.23 ? 62  GLU A CG  1 ? 
ATOM   246  C CD  . GLU A 1 30  ? -16.571 23.944  13.938 1.00 148.47 ? 62  GLU A CD  1 ? 
ATOM   247  O OE1 . GLU A 1 30  ? -17.289 24.547  14.763 1.00 145.37 ? 62  GLU A OE1 1 ? 
ATOM   248  O OE2 . GLU A 1 30  ? -16.043 24.504  12.949 1.00 136.13 ? 62  GLU A OE2 1 ? 
ATOM   249  N N   . LEU A 1 31  ? -16.234 18.869  14.909 1.00 104.15 ? 63  LEU A N   1 ? 
ATOM   250  C CA  . LEU A 1 31  ? -16.637 17.744  15.736 1.00 99.24  ? 63  LEU A CA  1 ? 
ATOM   251  C C   . LEU A 1 31  ? -17.524 18.249  16.869 1.00 98.47  ? 63  LEU A C   1 ? 
ATOM   252  O O   . LEU A 1 31  ? -17.032 18.797  17.857 1.00 94.93  ? 63  LEU A O   1 ? 
ATOM   253  C CB  . LEU A 1 31  ? -15.419 16.997  16.286 1.00 98.84  ? 63  LEU A CB  1 ? 
ATOM   254  C CG  . LEU A 1 31  ? -14.605 16.161  15.291 1.00 92.55  ? 63  LEU A CG  1 ? 
ATOM   255  C CD1 . LEU A 1 31  ? -13.428 15.502  15.996 1.00 89.97  ? 63  LEU A CD1 1 ? 
ATOM   256  C CD2 . LEU A 1 31  ? -15.451 15.110  14.594 1.00 90.24  ? 63  LEU A CD2 1 ? 
ATOM   257  N N   . LYS A 1 32  ? -18.831 18.015  16.706 1.00 106.54 ? 64  LYS A N   1 ? 
ATOM   258  C CA  . LYS A 1 32  ? -19.848 18.423  17.661 1.00 110.69 ? 64  LYS A CA  1 ? 
ATOM   259  C C   . LYS A 1 32  ? -20.492 17.180  18.279 1.00 99.58  ? 64  LYS A C   1 ? 
ATOM   260  O O   . LYS A 1 32  ? -20.896 16.271  17.553 1.00 90.90  ? 64  LYS A O   1 ? 
ATOM   261  C CB  . LYS A 1 32  ? -20.962 19.199  16.944 1.00 118.93 ? 64  LYS A CB  1 ? 
ATOM   262  C CG  . LYS A 1 32  ? -20.581 20.003  15.703 1.00 125.89 ? 64  LYS A CG  1 ? 
ATOM   263  C CD  . LYS A 1 32  ? -19.722 21.230  15.982 1.00 136.97 ? 64  LYS A CD  1 ? 
ATOM   264  C CE  . LYS A 1 32  ? -19.969 22.341  15.002 1.00 142.57 ? 64  LYS A CE  1 ? 
ATOM   265  N NZ  . LYS A 1 32  ? -19.484 23.628  15.508 1.00 142.21 ? 64  LYS A NZ  1 ? 
ATOM   266  N N   . ASP A 1 33  ? -20.644 17.179  19.609 1.00 90.14  ? 65  ASP A N   1 ? 
ATOM   267  C CA  . ASP A 1 33  ? -21.324 16.107  20.328 1.00 100.15 ? 65  ASP A CA  1 ? 
ATOM   268  C C   . ASP A 1 33  ? -22.580 15.633  19.591 1.00 102.56 ? 65  ASP A C   1 ? 
ATOM   269  O O   . ASP A 1 33  ? -22.912 14.448  19.629 1.00 100.57 ? 65  ASP A O   1 ? 
ATOM   270  C CB  . ASP A 1 33  ? -21.689 16.535  21.743 1.00 111.26 ? 65  ASP A CB  1 ? 
ATOM   271  C CG  . ASP A 1 33  ? -22.066 15.405  22.693 1.00 122.82 ? 65  ASP A CG  1 ? 
ATOM   272  O OD1 . ASP A 1 33  ? -22.977 14.620  22.347 1.00 124.47 ? 65  ASP A OD1 1 ? 
ATOM   273  O OD2 . ASP A 1 33  ? -21.439 15.308  23.773 1.00 122.68 ? 65  ASP A OD2 1 ? 
ATOM   274  N N   . ASP A 1 34  ? -23.272 16.559  18.917 1.00 104.37 ? 66  ASP A N   1 ? 
ATOM   275  C CA  . ASP A 1 34  ? -24.575 16.299  18.324 1.00 106.38 ? 66  ASP A CA  1 ? 
ATOM   276  C C   . ASP A 1 34  ? -24.503 15.341  17.136 1.00 94.34  ? 66  ASP A C   1 ? 
ATOM   277  O O   . ASP A 1 34  ? -25.536 14.800  16.748 1.00 92.34  ? 66  ASP A O   1 ? 
ATOM   278  C CB  . ASP A 1 34  ? -25.243 17.586  17.858 1.00 123.03 ? 66  ASP A CB  1 ? 
ATOM   279  C CG  . ASP A 1 34  ? -25.336 18.699  18.893 1.00 129.92 ? 66  ASP A CG  1 ? 
ATOM   280  O OD1 . ASP A 1 34  ? -24.265 19.156  19.359 1.00 125.12 ? 66  ASP A OD1 1 ? 
ATOM   281  O OD2 . ASP A 1 34  ? -26.478 19.096  19.227 1.00 123.33 ? 66  ASP A OD2 1 ? 
ATOM   282  N N   . ASP A 1 35  ? -23.314 15.141  16.545 1.00 97.48  ? 67  ASP A N   1 ? 
ATOM   283  C CA  . ASP A 1 35  ? -23.189 14.382  15.302 1.00 104.01 ? 67  ASP A CA  1 ? 
ATOM   284  C C   . ASP A 1 35  ? -22.812 12.909  15.534 1.00 100.18 ? 67  ASP A C   1 ? 
ATOM   285  O O   . ASP A 1 35  ? -22.507 12.203  14.573 1.00 89.82  ? 67  ASP A O   1 ? 
ATOM   286  C CB  . ASP A 1 35  ? -22.221 15.078  14.357 1.00 106.71 ? 67  ASP A CB  1 ? 
ATOM   287  C CG  . ASP A 1 35  ? -22.623 16.493  13.961 1.00 108.90 ? 67  ASP A CG  1 ? 
ATOM   288  O OD1 . ASP A 1 35  ? -23.659 16.632  13.282 1.00 107.49 ? 67  ASP A OD1 1 ? 
ATOM   289  O OD2 . ASP A 1 35  ? -21.910 17.443  14.351 1.00 101.15 ? 67  ASP A OD2 1 ? 
ATOM   290  N N   . PHE A 1 36  ? -22.908 12.430  16.787 1.00 97.86  ? 68  PHE A N   1 ? 
ATOM   291  C CA  . PHE A 1 36  ? -22.411 11.121  17.193 1.00 98.57  ? 68  PHE A CA  1 ? 
ATOM   292  C C   . PHE A 1 36  ? -23.540 10.224  17.716 1.00 99.73  ? 68  PHE A C   1 ? 
ATOM   293  O O   . PHE A 1 36  ? -24.086 10.456  18.798 1.00 93.87  ? 68  PHE A O   1 ? 
ATOM   294  C CB  . PHE A 1 36  ? -21.323 11.340  18.253 1.00 89.81  ? 68  PHE A CB  1 ? 
ATOM   295  C CG  . PHE A 1 36  ? -19.980 11.733  17.659 1.00 89.46  ? 68  PHE A CG  1 ? 
ATOM   296  C CD1 . PHE A 1 36  ? -19.386 10.951  16.672 1.00 92.76  ? 68  PHE A CD1 1 ? 
ATOM   297  C CD2 . PHE A 1 36  ? -19.337 12.901  18.053 1.00 95.69  ? 68  PHE A CD2 1 ? 
ATOM   298  C CE1 . PHE A 1 36  ? -18.165 11.311  16.124 1.00 91.37  ? 68  PHE A CE1 1 ? 
ATOM   299  C CE2 . PHE A 1 36  ? -18.124 13.265  17.487 1.00 98.01  ? 68  PHE A CE2 1 ? 
ATOM   300  C CZ  . PHE A 1 36  ? -17.540 12.469  16.528 1.00 97.48  ? 68  PHE A CZ  1 ? 
ATOM   301  N N   . GLU A 1 37  ? -23.834 9.161   16.954 1.00 95.59  ? 69  GLU A N   1 ? 
ATOM   302  C CA  . GLU A 1 37  ? -24.778 8.130   17.357 1.00 100.68 ? 69  GLU A CA  1 ? 
ATOM   303  C C   . GLU A 1 37  ? -24.018 6.948   17.957 1.00 103.85 ? 69  GLU A C   1 ? 
ATOM   304  O O   . GLU A 1 37  ? -23.224 6.304   17.274 1.00 101.72 ? 69  GLU A O   1 ? 
ATOM   305  C CB  . GLU A 1 37  ? -25.597 7.678   16.147 1.00 105.21 ? 69  GLU A CB  1 ? 
ATOM   306  C CG  . GLU A 1 37  ? -26.884 6.946   16.516 1.00 112.46 ? 69  GLU A CG  1 ? 
ATOM   307  C CD  . GLU A 1 37  ? -27.954 7.809   17.162 1.00 121.81 ? 69  GLU A CD  1 ? 
ATOM   308  O OE1 . GLU A 1 37  ? -28.486 8.699   16.464 1.00 131.72 ? 69  GLU A OE1 1 ? 
ATOM   309  O OE2 . GLU A 1 37  ? -28.254 7.596   18.359 1.00 114.53 ? 69  GLU A OE2 1 ? 
ATOM   310  N N   . LYS A 1 38  ? -24.285 6.657   19.234 1.00 103.11 ? 70  LYS A N   1 ? 
ATOM   311  C CA  . LYS A 1 38  ? -23.584 5.598   19.944 1.00 95.93  ? 70  LYS A CA  1 ? 
ATOM   312  C C   . LYS A 1 38  ? -23.986 4.246   19.358 1.00 94.87  ? 70  LYS A C   1 ? 
ATOM   313  O O   . LYS A 1 38  ? -25.155 3.999   19.086 1.00 91.53  ? 70  LYS A O   1 ? 
ATOM   314  C CB  . LYS A 1 38  ? -23.804 5.709   21.458 1.00 93.96  ? 70  LYS A CB  1 ? 
ATOM   315  C CG  . LYS A 1 38  ? -22.906 6.749   22.152 1.00 108.58 ? 70  LYS A CG  1 ? 
ATOM   316  C CD  . LYS A 1 38  ? -23.054 8.203   21.700 1.00 112.99 ? 70  LYS A CD  1 ? 
ATOM   317  C CE  . LYS A 1 38  ? -21.797 9.035   21.762 1.00 109.42 ? 70  LYS A CE  1 ? 
ATOM   318  N NZ  . LYS A 1 38  ? -21.125 9.029   23.064 1.00 104.20 ? 70  LYS A NZ  1 ? 
ATOM   319  N N   . ILE A 1 39  ? -22.984 3.395   19.124 1.00 103.93 ? 71  ILE A N   1 ? 
ATOM   320  C CA  . ILE A 1 39  ? -23.193 2.061   18.589 1.00 98.03  ? 71  ILE A CA  1 ? 
ATOM   321  C C   . ILE A 1 39  ? -23.057 1.058   19.734 1.00 99.90  ? 71  ILE A C   1 ? 
ATOM   322  O O   . ILE A 1 39  ? -23.852 0.124   19.829 1.00 106.34 ? 71  ILE A O   1 ? 
ATOM   323  C CB  . ILE A 1 39  ? -22.209 1.768   17.437 1.00 95.57  ? 71  ILE A CB  1 ? 
ATOM   324  C CG1 . ILE A 1 39  ? -22.112 2.951   16.455 1.00 98.67  ? 71  ILE A CG1 1 ? 
ATOM   325  C CG2 . ILE A 1 39  ? -22.582 0.471   16.719 1.00 98.73  ? 71  ILE A CG2 1 ? 
ATOM   326  C CD1 . ILE A 1 39  ? -21.200 2.728   15.257 1.00 99.51  ? 71  ILE A CD1 1 ? 
ATOM   327  N N   . SER A 1 40  ? -22.049 1.266   20.598 1.00 93.57  ? 72  SER A N   1 ? 
ATOM   328  C CA  . SER A 1 40  ? -21.730 0.333   21.669 1.00 85.22  ? 72  SER A CA  1 ? 
ATOM   329  C C   . SER A 1 40  ? -20.732 0.952   22.648 1.00 79.35  ? 72  SER A C   1 ? 
ATOM   330  O O   . SER A 1 40  ? -20.170 2.005   22.379 1.00 85.20  ? 72  SER A O   1 ? 
ATOM   331  C CB  . SER A 1 40  ? -21.185 -0.961  21.102 1.00 83.05  ? 72  SER A CB  1 ? 
ATOM   332  O OG  . SER A 1 40  ? -19.765 -0.964  21.088 1.00 91.01  ? 72  SER A OG  1 ? 
ATOM   333  N N   . GLU A 1 41  ? -20.498 0.265   23.772 1.00 84.42  ? 73  GLU A N   1 ? 
ATOM   334  C CA  . GLU A 1 41  ? -19.505 0.665   24.757 1.00 90.44  ? 73  GLU A CA  1 ? 
ATOM   335  C C   . GLU A 1 41  ? -18.297 -0.267  24.670 1.00 101.83 ? 73  GLU A C   1 ? 
ATOM   336  O O   . GLU A 1 41  ? -18.327 -1.396  25.161 1.00 98.14  ? 73  GLU A O   1 ? 
ATOM   337  C CB  . GLU A 1 41  ? -20.103 0.657   26.163 1.00 97.22  ? 73  GLU A CB  1 ? 
ATOM   338  C CG  . GLU A 1 41  ? -19.121 1.055   27.264 1.00 101.86 ? 73  GLU A CG  1 ? 
ATOM   339  C CD  . GLU A 1 41  ? -19.791 1.423   28.585 1.00 118.64 ? 73  GLU A CD  1 ? 
ATOM   340  O OE1 . GLU A 1 41  ? -20.634 2.354   28.612 1.00 119.46 ? 73  GLU A OE1 1 ? 
ATOM   341  O OE2 . GLU A 1 41  ? -19.469 0.770   29.601 1.00 124.90 ? 73  GLU A OE2 1 ? 
ATOM   342  N N   . LEU A 1 42  ? -17.226 0.228   24.042 1.00 98.51  ? 74  LEU A N   1 ? 
ATOM   343  C CA  . LEU A 1 42  ? -15.962 -0.482  24.006 1.00 92.70  ? 74  LEU A CA  1 ? 
ATOM   344  C C   . LEU A 1 42  ? -15.380 -0.500  25.412 1.00 94.91  ? 74  LEU A C   1 ? 
ATOM   345  O O   . LEU A 1 42  ? -15.920 0.140   26.310 1.00 101.42 ? 74  LEU A O   1 ? 
ATOM   346  C CB  . LEU A 1 42  ? -15.017 0.208   23.027 1.00 87.45  ? 74  LEU A CB  1 ? 
ATOM   347  C CG  . LEU A 1 42  ? -15.553 0.351   21.603 1.00 83.06  ? 74  LEU A CG  1 ? 
ATOM   348  C CD1 . LEU A 1 42  ? -14.642 1.235   20.780 1.00 78.53  ? 74  LEU A CD1 1 ? 
ATOM   349  C CD2 . LEU A 1 42  ? -15.750 -1.014  20.960 1.00 87.14  ? 74  LEU A CD2 1 ? 
ATOM   350  N N   . GLY A 1 43  ? -14.282 -1.241  25.586 1.00 95.63  ? 75  GLY A N   1 ? 
ATOM   351  C CA  . GLY A 1 43  ? -13.493 -1.137  26.799 1.00 113.25 ? 75  GLY A CA  1 ? 
ATOM   352  C C   . GLY A 1 43  ? -13.721 0.220   27.461 1.00 126.95 ? 75  GLY A C   1 ? 
ATOM   353  O O   . GLY A 1 43  ? -13.297 1.250   26.939 1.00 135.61 ? 75  GLY A O   1 ? 
ATOM   354  N N   . ALA A 1 44  ? -14.429 0.197   28.596 1.00 139.34 ? 76  ALA A N   1 ? 
ATOM   355  C CA  . ALA A 1 44  ? -14.831 1.399   29.307 1.00 139.28 ? 76  ALA A CA  1 ? 
ATOM   356  C C   . ALA A 1 44  ? -13.924 1.605   30.520 1.00 145.64 ? 76  ALA A C   1 ? 
ATOM   357  O O   . ALA A 1 44  ? -12.867 0.986   30.613 1.00 156.12 ? 76  ALA A O   1 ? 
ATOM   358  C CB  . ALA A 1 44  ? -16.287 1.263   29.697 1.00 139.08 ? 76  ALA A CB  1 ? 
ATOM   359  N N   . GLY A 1 45  ? -14.333 2.491   31.437 1.00 144.06 ? 77  GLY A N   1 ? 
ATOM   360  C CA  . GLY A 1 45  ? -13.647 2.656   32.708 1.00 141.06 ? 77  GLY A CA  1 ? 
ATOM   361  C C   . GLY A 1 45  ? -12.332 3.415   32.539 1.00 148.03 ? 77  GLY A C   1 ? 
ATOM   362  O O   . GLY A 1 45  ? -12.320 4.493   31.956 1.00 154.23 ? 77  GLY A O   1 ? 
ATOM   363  N N   . ASN A 1 46  ? -11.236 2.827   33.043 1.00 152.28 ? 78  ASN A N   1 ? 
ATOM   364  C CA  . ASN A 1 46  ? -9.918  3.455   33.118 1.00 147.76 ? 78  ASN A CA  1 ? 
ATOM   365  C C   . ASN A 1 46  ? -10.080 4.946   33.438 1.00 141.91 ? 78  ASN A C   1 ? 
ATOM   366  O O   . ASN A 1 46  ? -10.812 5.292   34.366 1.00 122.80 ? 78  ASN A O   1 ? 
ATOM   367  C CB  . ASN A 1 46  ? -9.018  3.022   31.951 1.00 145.75 ? 78  ASN A CB  1 ? 
ATOM   368  C CG  . ASN A 1 46  ? -9.645  3.093   30.572 1.00 145.08 ? 78  ASN A CG  1 ? 
ATOM   369  O OD1 . ASN A 1 46  ? -9.977  2.056   29.984 1.00 134.81 ? 78  ASN A OD1 1 ? 
ATOM   370  N ND2 . ASN A 1 46  ? -9.768  4.282   30.000 1.00 139.65 ? 78  ASN A ND2 1 ? 
ATOM   371  N N   . GLY A 1 47  ? -9.363  5.819   32.714 1.00 142.60 ? 79  GLY A N   1 ? 
ATOM   372  C CA  . GLY A 1 47  ? -9.529  7.260   32.831 1.00 140.62 ? 79  GLY A CA  1 ? 
ATOM   373  C C   . GLY A 1 47  ? -10.937 7.717   32.438 1.00 139.41 ? 79  GLY A C   1 ? 
ATOM   374  O O   . GLY A 1 47  ? -11.430 8.712   32.968 1.00 133.49 ? 79  GLY A O   1 ? 
ATOM   375  N N   . GLY A 1 48  ? -11.574 6.991   31.505 1.00 123.34 ? 80  GLY A N   1 ? 
ATOM   376  C CA  . GLY A 1 48  ? -12.933 7.290   31.079 1.00 110.94 ? 80  GLY A CA  1 ? 
ATOM   377  C C   . GLY A 1 48  ? -13.483 6.217   30.139 1.00 109.27 ? 80  GLY A C   1 ? 
ATOM   378  O O   . GLY A 1 48  ? -12.732 5.467   29.521 1.00 121.61 ? 80  GLY A O   1 ? 
ATOM   379  N N   . VAL A 1 49  ? -14.810 6.150   30.033 1.00 100.71 ? 81  VAL A N   1 ? 
ATOM   380  C CA  . VAL A 1 49  ? -15.440 5.208   29.129 1.00 97.97  ? 81  VAL A CA  1 ? 
ATOM   381  C C   . VAL A 1 49  ? -15.009 5.556   27.707 1.00 87.63  ? 81  VAL A C   1 ? 
ATOM   382  O O   . VAL A 1 49  ? -14.693 6.705   27.418 1.00 98.60  ? 81  VAL A O   1 ? 
ATOM   383  C CB  . VAL A 1 49  ? -16.974 5.226   29.278 1.00 107.91 ? 81  VAL A CB  1 ? 
ATOM   384  C CG1 . VAL A 1 49  ? -17.657 4.231   28.347 1.00 111.89 ? 81  VAL A CG1 1 ? 
ATOM   385  C CG2 . VAL A 1 49  ? -17.412 4.964   30.713 1.00 117.33 ? 81  VAL A CG2 1 ? 
ATOM   386  N N   . VAL A 1 50  ? -14.999 4.548   26.830 1.00 76.60  ? 82  VAL A N   1 ? 
ATOM   387  C CA  . VAL A 1 50  ? -14.772 4.745   25.411 1.00 73.20  ? 82  VAL A CA  1 ? 
ATOM   388  C C   . VAL A 1 50  ? -15.932 4.113   24.654 1.00 73.83  ? 82  VAL A C   1 ? 
ATOM   389  O O   . VAL A 1 50  ? -16.275 2.966   24.932 1.00 72.33  ? 82  VAL A O   1 ? 
ATOM   390  C CB  . VAL A 1 50  ? -13.438 4.114   24.979 1.00 83.07  ? 82  VAL A CB  1 ? 
ATOM   391  C CG1 . VAL A 1 50  ? -13.249 4.159   23.466 1.00 81.90  ? 82  VAL A CG1 1 ? 
ATOM   392  C CG2 . VAL A 1 50  ? -12.256 4.751   25.701 1.00 85.08  ? 82  VAL A CG2 1 ? 
ATOM   393  N N   . PHE A 1 51  ? -16.497 4.853   23.686 1.00 69.72  ? 83  PHE A N   1 ? 
ATOM   394  C CA  . PHE A 1 51  ? -17.639 4.383   22.922 1.00 73.53  ? 83  PHE A CA  1 ? 
ATOM   395  C C   . PHE A 1 51  ? -17.248 4.197   21.463 1.00 70.42  ? 83  PHE A C   1 ? 
ATOM   396  O O   . PHE A 1 51  ? -16.462 4.962   20.917 1.00 78.98  ? 83  PHE A O   1 ? 
ATOM   397  C CB  . PHE A 1 51  ? -18.834 5.340   22.991 1.00 79.57  ? 83  PHE A CB  1 ? 
ATOM   398  C CG  . PHE A 1 51  ? -19.295 5.587   24.417 1.00 80.59  ? 83  PHE A CG  1 ? 
ATOM   399  C CD1 . PHE A 1 51  ? -19.965 4.598   25.127 1.00 82.38  ? 83  PHE A CD1 1 ? 
ATOM   400  C CD2 . PHE A 1 51  ? -19.026 6.789   25.056 1.00 86.80  ? 83  PHE A CD2 1 ? 
ATOM   401  C CE1 . PHE A 1 51  ? -20.362 4.809   26.435 1.00 76.38  ? 83  PHE A CE1 1 ? 
ATOM   402  C CE2 . PHE A 1 51  ? -19.436 7.001   26.363 1.00 89.43  ? 83  PHE A CE2 1 ? 
ATOM   403  C CZ  . PHE A 1 51  ? -20.111 6.016   27.045 1.00 83.15  ? 83  PHE A CZ  1 ? 
ATOM   404  N N   . LYS A 1 52  ? -17.814 3.159   20.849 1.00 67.44  ? 84  LYS A N   1 ? 
ATOM   405  C CA  . LYS A 1 52  ? -17.872 3.070   19.406 1.00 67.93  ? 84  LYS A CA  1 ? 
ATOM   406  C C   . LYS A 1 52  ? -19.070 3.895   18.964 1.00 76.79  ? 84  LYS A C   1 ? 
ATOM   407  O O   . LYS A 1 52  ? -20.134 3.779   19.573 1.00 79.67  ? 84  LYS A O   1 ? 
ATOM   408  C CB  . LYS A 1 52  ? -18.024 1.603   19.005 1.00 59.84  ? 84  LYS A CB  1 ? 
ATOM   409  C CG  . LYS A 1 52  ? -18.125 1.345   17.525 1.00 62.56  ? 84  LYS A CG  1 ? 
ATOM   410  C CD  . LYS A 1 52  ? -18.432 -0.131  17.289 1.00 68.71  ? 84  LYS A CD  1 ? 
ATOM   411  C CE  . LYS A 1 52  ? -18.333 -0.569  15.862 1.00 70.06  ? 84  LYS A CE  1 ? 
ATOM   412  N NZ  . LYS A 1 52  ? -18.200 -2.025  15.830 1.00 69.96  ? 84  LYS A NZ  1 ? 
ATOM   413  N N   . VAL A 1 53  ? -18.874 4.731   17.934 1.00 77.00  ? 85  VAL A N   1 ? 
ATOM   414  C CA  . VAL A 1 53  ? -19.885 5.684   17.506 1.00 73.96  ? 85  VAL A CA  1 ? 
ATOM   415  C C   . VAL A 1 53  ? -19.889 5.783   15.984 1.00 78.68  ? 85  VAL A C   1 ? 
ATOM   416  O O   . VAL A 1 53  ? -18.870 5.564   15.336 1.00 80.91  ? 85  VAL A O   1 ? 
ATOM   417  C CB  . VAL A 1 53  ? -19.648 7.064   18.140 1.00 73.58  ? 85  VAL A CB  1 ? 
ATOM   418  C CG1 . VAL A 1 53  ? -19.660 7.011   19.660 1.00 77.55  ? 85  VAL A CG1 1 ? 
ATOM   419  C CG2 . VAL A 1 53  ? -18.346 7.692   17.666 1.00 83.18  ? 85  VAL A CG2 1 ? 
ATOM   420  N N   . SER A 1 54  ? -21.057 6.114   15.425 1.00 85.85  ? 86  SER A N   1 ? 
ATOM   421  C CA  . SER A 1 54  ? -21.142 6.587   14.055 1.00 83.73  ? 86  SER A CA  1 ? 
ATOM   422  C C   . SER A 1 54  ? -21.179 8.108   14.078 1.00 82.00  ? 86  SER A C   1 ? 
ATOM   423  O O   . SER A 1 54  ? -21.793 8.699   14.960 1.00 75.73  ? 86  SER A O   1 ? 
ATOM   424  C CB  . SER A 1 54  ? -22.331 6.035   13.331 1.00 93.31  ? 86  SER A CB  1 ? 
ATOM   425  O OG  . SER A 1 54  ? -22.412 6.592   12.024 1.00 104.39 ? 86  SER A OG  1 ? 
ATOM   426  N N   . HIS A 1 55  ? -20.476 8.719   13.122 1.00 98.29  ? 87  HIS A N   1 ? 
ATOM   427  C CA  . HIS A 1 55  ? -20.506 10.159  12.928 1.00 95.03  ? 87  HIS A CA  1 ? 
ATOM   428  C C   . HIS A 1 55  ? -21.394 10.418  11.720 1.00 89.72  ? 87  HIS A C   1 ? 
ATOM   429  O O   . HIS A 1 55  ? -20.978 10.148  10.590 1.00 85.47  ? 87  HIS A O   1 ? 
ATOM   430  C CB  . HIS A 1 55  ? -19.086 10.696  12.747 1.00 91.27  ? 87  HIS A CB  1 ? 
ATOM   431  C CG  . HIS A 1 55  ? -18.982 12.174  12.639 1.00 96.69  ? 87  HIS A CG  1 ? 
ATOM   432  N ND1 . HIS A 1 55  ? -18.852 12.810  11.423 1.00 100.74 ? 87  HIS A ND1 1 ? 
ATOM   433  C CD2 . HIS A 1 55  ? -18.944 13.130  13.575 1.00 94.75  ? 87  HIS A CD2 1 ? 
ATOM   434  C CE1 . HIS A 1 55  ? -18.758 14.116  11.630 1.00 107.84 ? 87  HIS A CE1 1 ? 
ATOM   435  N NE2 . HIS A 1 55  ? -18.814 14.332  12.930 1.00 109.51 ? 87  HIS A NE2 1 ? 
ATOM   436  N N   . LYS A 1 56  ? -22.615 10.905  11.991 1.00 82.32  ? 88  LYS A N   1 ? 
ATOM   437  C CA  . LYS A 1 56  ? -23.694 10.905  11.012 1.00 91.48  ? 88  LYS A CA  1 ? 
ATOM   438  C C   . LYS A 1 56  ? -23.271 11.602  9.719  1.00 87.17  ? 88  LYS A C   1 ? 
ATOM   439  O O   . LYS A 1 56  ? -23.490 11.065  8.633  1.00 85.51  ? 88  LYS A O   1 ? 
ATOM   440  C CB  . LYS A 1 56  ? -24.986 11.531  11.553 1.00 100.69 ? 88  LYS A CB  1 ? 
ATOM   441  C CG  . LYS A 1 56  ? -26.058 10.542  12.016 1.00 110.03 ? 88  LYS A CG  1 ? 
ATOM   442  C CD  . LYS A 1 56  ? -25.994 10.133  13.483 1.00 116.66 ? 88  LYS A CD  1 ? 
ATOM   443  C CE  . LYS A 1 56  ? -26.737 11.051  14.416 1.00 115.21 ? 88  LYS A CE  1 ? 
ATOM   444  N NZ  . LYS A 1 56  ? -26.183 12.405  14.482 1.00 117.56 ? 88  LYS A NZ  1 ? 
ATOM   445  N N   . PRO A 1 57  ? -22.674 12.817  9.784  1.00 78.50  ? 89  PRO A N   1 ? 
ATOM   446  C CA  . PRO A 1 57  ? -22.293 13.538  8.570  1.00 83.33  ? 89  PRO A CA  1 ? 
ATOM   447  C C   . PRO A 1 57  ? -21.449 12.653  7.654  1.00 92.33  ? 89  PRO A C   1 ? 
ATOM   448  O O   . PRO A 1 57  ? -21.817 12.411  6.505  1.00 92.40  ? 89  PRO A O   1 ? 
ATOM   449  C CB  . PRO A 1 57  ? -21.523 14.774  9.098  1.00 84.08  ? 89  PRO A CB  1 ? 
ATOM   450  C CG  . PRO A 1 57  ? -21.985 14.945  10.539 1.00 77.99  ? 89  PRO A CG  1 ? 
ATOM   451  C CD  . PRO A 1 57  ? -22.338 13.552  11.017 1.00 79.63  ? 89  PRO A CD  1 ? 
ATOM   452  N N   . SER A 1 58  ? -20.342 12.137  8.205  1.00 101.69 ? 90  SER A N   1 ? 
ATOM   453  C CA  . SER A 1 58  ? -19.358 11.377  7.448  1.00 98.18  ? 90  SER A CA  1 ? 
ATOM   454  C C   . SER A 1 58  ? -19.880 9.987   7.092  1.00 95.73  ? 90  SER A C   1 ? 
ATOM   455  O O   . SER A 1 58  ? -19.666 9.520   5.971  1.00 92.87  ? 90  SER A O   1 ? 
ATOM   456  C CB  . SER A 1 58  ? -18.066 11.281  8.218  1.00 104.44 ? 90  SER A CB  1 ? 
ATOM   457  O OG  . SER A 1 58  ? -18.283 10.755  9.520  1.00 113.95 ? 90  SER A OG  1 ? 
ATOM   458  N N   . GLY A 1 59  ? -20.564 9.346   8.052  1.00 83.10  ? 91  GLY A N   1 ? 
ATOM   459  C CA  . GLY A 1 59  ? -20.838 7.919   7.984  1.00 93.27  ? 91  GLY A CA  1 ? 
ATOM   460  C C   . GLY A 1 59  ? -19.601 7.102   8.355  1.00 96.71  ? 91  GLY A C   1 ? 
ATOM   461  O O   . GLY A 1 59  ? -19.385 6.020   7.811  1.00 99.72  ? 91  GLY A O   1 ? 
ATOM   462  N N   . LEU A 1 60  ? -18.791 7.646   9.276  1.00 85.79  ? 92  LEU A N   1 ? 
ATOM   463  C CA  . LEU A 1 60  ? -17.588 6.984   9.745  1.00 87.02  ? 92  LEU A CA  1 ? 
ATOM   464  C C   . LEU A 1 60  ? -17.857 6.399   11.126 1.00 93.34  ? 92  LEU A C   1 ? 
ATOM   465  O O   . LEU A 1 60  ? -18.469 7.059   11.971 1.00 81.32  ? 92  LEU A O   1 ? 
ATOM   466  C CB  . LEU A 1 60  ? -16.398 7.941   9.811  1.00 83.38  ? 92  LEU A CB  1 ? 
ATOM   467  C CG  . LEU A 1 60  ? -15.720 8.302   8.488  1.00 86.11  ? 92  LEU A CG  1 ? 
ATOM   468  C CD1 . LEU A 1 60  ? -14.419 9.038   8.759  1.00 84.98  ? 92  LEU A CD1 1 ? 
ATOM   469  C CD2 . LEU A 1 60  ? -15.467 7.098   7.602  1.00 91.09  ? 92  LEU A CD2 1 ? 
ATOM   470  N N   . VAL A 1 61  ? -17.362 5.170   11.334 1.00 82.96  ? 93  VAL A N   1 ? 
ATOM   471  C CA  . VAL A 1 61  ? -17.269 4.590   12.662 1.00 75.51  ? 93  VAL A CA  1 ? 
ATOM   472  C C   . VAL A 1 61  ? -15.971 5.070   13.297 1.00 69.13  ? 93  VAL A C   1 ? 
ATOM   473  O O   . VAL A 1 61  ? -14.928 5.004   12.656 1.00 71.18  ? 93  VAL A O   1 ? 
ATOM   474  C CB  . VAL A 1 61  ? -17.303 3.053   12.635 1.00 79.05  ? 93  VAL A CB  1 ? 
ATOM   475  C CG1 . VAL A 1 61  ? -17.378 2.489   14.052 1.00 77.63  ? 93  VAL A CG1 1 ? 
ATOM   476  C CG2 . VAL A 1 61  ? -18.441 2.520   11.762 1.00 82.78  ? 93  VAL A CG2 1 ? 
ATOM   477  N N   . MET A 1 62  ? -16.052 5.516   14.559 1.00 61.93  ? 94  MET A N   1 ? 
ATOM   478  C CA  . MET A 1 62  ? -14.897 5.988   15.305 1.00 60.16  ? 94  MET A CA  1 ? 
ATOM   479  C C   . MET A 1 62  ? -14.944 5.463   16.736 1.00 62.20  ? 94  MET A C   1 ? 
ATOM   480  O O   . MET A 1 62  ? -15.996 5.050   17.207 1.00 65.79  ? 94  MET A O   1 ? 
ATOM   481  C CB  . MET A 1 62  ? -14.885 7.510   15.442 1.00 65.63  ? 94  MET A CB  1 ? 
ATOM   482  C CG  . MET A 1 62  ? -15.011 8.279   14.153 1.00 71.59  ? 94  MET A CG  1 ? 
ATOM   483  S SD  . MET A 1 62  ? -14.974 10.041  14.539 1.00 77.74  ? 94  MET A SD  1 ? 
ATOM   484  C CE  . MET A 1 62  ? -15.289 10.596  12.859 1.00 89.41  ? 94  MET A CE  1 ? 
ATOM   485  N N   . ALA A 1 63  ? -13.804 5.524   17.432 1.00 60.72  ? 95  ALA A N   1 ? 
ATOM   486  C CA  . ALA A 1 63  ? -13.772 5.320   18.868 1.00 68.42  ? 95  ALA A CA  1 ? 
ATOM   487  C C   . ALA A 1 63  ? -13.673 6.680   19.541 1.00 74.35  ? 95  ALA A C   1 ? 
ATOM   488  O O   . ALA A 1 63  ? -12.708 7.402   19.303 1.00 86.91  ? 95  ALA A O   1 ? 
ATOM   489  C CB  . ALA A 1 63  ? -12.604 4.440   19.259 1.00 73.44  ? 95  ALA A CB  1 ? 
ATOM   490  N N   . ARG A 1 64  ? -14.671 7.014   20.370 1.00 76.87  ? 96  ARG A N   1 ? 
ATOM   491  C CA  . ARG A 1 64  ? -14.687 8.270   21.102 1.00 72.13  ? 96  ARG A CA  1 ? 
ATOM   492  C C   . ARG A 1 64  ? -14.468 7.995   22.582 1.00 67.89  ? 96  ARG A C   1 ? 
ATOM   493  O O   . ARG A 1 64  ? -15.250 7.287   23.202 1.00 76.35  ? 96  ARG A O   1 ? 
ATOM   494  C CB  . ARG A 1 64  ? -16.031 8.972   20.898 1.00 77.86  ? 96  ARG A CB  1 ? 
ATOM   495  C CG  . ARG A 1 64  ? -16.250 10.197  21.774 1.00 77.58  ? 96  ARG A CG  1 ? 
ATOM   496  C CD  . ARG A 1 64  ? -17.662 10.699  21.533 1.00 88.41  ? 96  ARG A CD  1 ? 
ATOM   497  N NE  . ARG A 1 64  ? -18.060 11.889  22.293 1.00 97.95  ? 96  ARG A NE  1 ? 
ATOM   498  C CZ  . ARG A 1 64  ? -19.236 12.508  22.155 1.00 101.32 ? 96  ARG A CZ  1 ? 
ATOM   499  N NH1 . ARG A 1 64  ? -20.141 12.059  21.292 1.00 99.54  ? 96  ARG A NH1 1 ? 
ATOM   500  N NH2 . ARG A 1 64  ? -19.501 13.582  22.883 1.00 93.49  ? 96  ARG A NH2 1 ? 
ATOM   501  N N   . LYS A 1 65  ? -13.396 8.562   23.134 1.00 75.42  ? 97  LYS A N   1 ? 
ATOM   502  C CA  . LYS A 1 65  ? -13.091 8.424   24.547 1.00 77.71  ? 97  LYS A CA  1 ? 
ATOM   503  C C   . LYS A 1 65  ? -13.577 9.687   25.243 1.00 81.46  ? 97  LYS A C   1 ? 
ATOM   504  O O   . LYS A 1 65  ? -13.281 10.776  24.754 1.00 75.58  ? 97  LYS A O   1 ? 
ATOM   505  C CB  . LYS A 1 65  ? -11.577 8.277   24.745 1.00 79.67  ? 97  LYS A CB  1 ? 
ATOM   506  C CG  . LYS A 1 65  ? -11.089 8.146   26.196 1.00 86.16  ? 97  LYS A CG  1 ? 
ATOM   507  C CD  . LYS A 1 65  ? -9.719  8.758   26.477 1.00 96.93  ? 97  LYS A CD  1 ? 
ATOM   508  C CE  . LYS A 1 65  ? -8.545  7.888   26.175 1.00 106.46 ? 97  LYS A CE  1 ? 
ATOM   509  N NZ  . LYS A 1 65  ? -8.306  6.958   27.280 1.00 114.86 ? 97  LYS A NZ  1 ? 
ATOM   510  N N   . LEU A 1 66  ? -14.310 9.531   26.359 1.00 87.40  ? 98  LEU A N   1 ? 
ATOM   511  C CA  . LEU A 1 66  ? -14.774 10.661  27.160 1.00 92.85  ? 98  LEU A CA  1 ? 
ATOM   512  C C   . LEU A 1 66  ? -14.079 10.638  28.519 1.00 91.32  ? 98  LEU A C   1 ? 
ATOM   513  O O   . LEU A 1 66  ? -14.168 9.633   29.217 1.00 93.57  ? 98  LEU A O   1 ? 
ATOM   514  C CB  . LEU A 1 66  ? -16.291 10.675  27.356 1.00 96.28  ? 98  LEU A CB  1 ? 
ATOM   515  C CG  . LEU A 1 66  ? -17.128 11.081  26.138 1.00 107.91 ? 98  LEU A CG  1 ? 
ATOM   516  C CD1 . LEU A 1 66  ? -17.342 9.870   25.254 1.00 111.23 ? 98  LEU A CD1 1 ? 
ATOM   517  C CD2 . LEU A 1 66  ? -18.462 11.720  26.507 1.00 110.92 ? 98  LEU A CD2 1 ? 
ATOM   518  N N   . ILE A 1 67  ? -13.402 11.746  28.874 1.00 99.89  ? 99  ILE A N   1 ? 
ATOM   519  C CA  . ILE A 1 67  ? -12.950 12.004  30.239 1.00 112.78 ? 99  ILE A CA  1 ? 
ATOM   520  C C   . ILE A 1 67  ? -13.717 13.198  30.810 1.00 124.78 ? 99  ILE A C   1 ? 
ATOM   521  O O   . ILE A 1 67  ? -13.813 14.246  30.172 1.00 127.28 ? 99  ILE A O   1 ? 
ATOM   522  C CB  . ILE A 1 67  ? -11.426 12.220  30.379 1.00 114.88 ? 99  ILE A CB  1 ? 
ATOM   523  C CG1 . ILE A 1 67  ? -10.734 12.605  29.071 1.00 119.21 ? 99  ILE A CG1 1 ? 
ATOM   524  C CG2 . ILE A 1 67  ? -10.760 10.997  31.011 1.00 124.66 ? 99  ILE A CG2 1 ? 
ATOM   525  C CD1 . ILE A 1 67  ? -10.401 11.435  28.163 1.00 114.30 ? 99  ILE A CD1 1 ? 
ATOM   526  N N   . HIS A 1 68  ? -14.237 13.016  32.033 1.00 131.48 ? 100 HIS A N   1 ? 
ATOM   527  C CA  . HIS A 1 68  ? -14.947 14.055  32.760 1.00 135.86 ? 100 HIS A CA  1 ? 
ATOM   528  C C   . HIS A 1 68  ? -13.929 15.029  33.346 1.00 132.78 ? 100 HIS A C   1 ? 
ATOM   529  O O   . HIS A 1 68  ? -12.989 14.625  34.028 1.00 123.40 ? 100 HIS A O   1 ? 
ATOM   530  C CB  . HIS A 1 68  ? -15.838 13.451  33.855 1.00 146.47 ? 100 HIS A CB  1 ? 
ATOM   531  C CG  . HIS A 1 68  ? -16.800 14.418  34.474 1.00 157.28 ? 100 HIS A CG  1 ? 
ATOM   532  N ND1 . HIS A 1 68  ? -16.455 15.291  35.486 1.00 154.13 ? 100 HIS A ND1 1 ? 
ATOM   533  C CD2 . HIS A 1 68  ? -18.097 14.650  34.216 1.00 159.13 ? 100 HIS A CD2 1 ? 
ATOM   534  C CE1 . HIS A 1 68  ? -17.513 16.019  35.817 1.00 156.05 ? 100 HIS A CE1 1 ? 
ATOM   535  N NE2 . HIS A 1 68  ? -18.522 15.644  35.060 1.00 158.29 ? 100 HIS A NE2 1 ? 
ATOM   536  N N   . LEU A 1 69  ? -14.125 16.315  33.047 1.00 141.50 ? 101 LEU A N   1 ? 
ATOM   537  C CA  . LEU A 1 69  ? -13.292 17.380  33.577 1.00 146.85 ? 101 LEU A CA  1 ? 
ATOM   538  C C   . LEU A 1 69  ? -14.094 18.673  33.440 1.00 150.43 ? 101 LEU A C   1 ? 
ATOM   539  O O   . LEU A 1 69  ? -14.551 18.996  32.343 1.00 134.06 ? 101 LEU A O   1 ? 
ATOM   540  C CB  . LEU A 1 69  ? -11.965 17.428  32.812 1.00 145.51 ? 101 LEU A CB  1 ? 
ATOM   541  C CG  . LEU A 1 69  ? -10.663 17.492  33.627 1.00 146.90 ? 101 LEU A CG  1 ? 
ATOM   542  C CD1 . LEU A 1 69  ? -10.760 18.262  34.943 1.00 148.41 ? 101 LEU A CD1 1 ? 
ATOM   543  C CD2 . LEU A 1 69  ? -10.115 16.089  33.870 1.00 143.78 ? 101 LEU A CD2 1 ? 
ATOM   544  N N   . GLU A 1 70  ? -14.300 19.374  34.565 1.00 155.67 ? 102 GLU A N   1 ? 
ATOM   545  C CA  . GLU A 1 70  ? -15.150 20.556  34.610 1.00 155.26 ? 102 GLU A CA  1 ? 
ATOM   546  C C   . GLU A 1 70  ? -14.290 21.811  34.474 1.00 152.36 ? 102 GLU A C   1 ? 
ATOM   547  O O   . GLU A 1 70  ? -13.072 21.747  34.631 1.00 145.41 ? 102 GLU A O   1 ? 
ATOM   548  C CB  . GLU A 1 70  ? -16.017 20.569  35.874 1.00 152.13 ? 102 GLU A CB  1 ? 
ATOM   549  C CG  . GLU A 1 70  ? -17.304 19.754  35.752 1.00 143.44 ? 102 GLU A CG  1 ? 
ATOM   550  C CD  . GLU A 1 70  ? -18.381 20.347  34.853 1.00 135.54 ? 102 GLU A CD  1 ? 
ATOM   551  O OE1 . GLU A 1 70  ? -18.239 21.504  34.398 1.00 130.25 ? 102 GLU A OE1 1 ? 
ATOM   552  O OE2 . GLU A 1 70  ? -19.373 19.637  34.596 1.00 124.89 ? 102 GLU A OE2 1 ? 
ATOM   553  N N   . ILE A 1 71  ? -14.971 22.938  34.206 1.00 161.45 ? 103 ILE A N   1 ? 
ATOM   554  C CA  . ILE A 1 71  ? -14.400 24.220  33.807 1.00 168.90 ? 103 ILE A CA  1 ? 
ATOM   555  C C   . ILE A 1 71  ? -14.354 24.244  32.277 1.00 178.79 ? 103 ILE A C   1 ? 
ATOM   556  O O   . ILE A 1 71  ? -14.071 23.226  31.649 1.00 183.93 ? 103 ILE A O   1 ? 
ATOM   557  C CB  . ILE A 1 71  ? -13.033 24.516  34.471 1.00 158.55 ? 103 ILE A CB  1 ? 
ATOM   558  C CG1 . ILE A 1 71  ? -12.984 25.929  35.059 1.00 148.59 ? 103 ILE A CG1 1 ? 
ATOM   559  C CG2 . ILE A 1 71  ? -11.854 24.256  33.529 1.00 165.33 ? 103 ILE A CG2 1 ? 
ATOM   560  C CD1 . ILE A 1 71  ? -11.607 26.360  35.533 1.00 150.05 ? 103 ILE A CD1 1 ? 
ATOM   561  N N   . LYS A 1 72  ? -14.686 25.398  31.679 1.00 181.51 ? 104 LYS A N   1 ? 
ATOM   562  C CA  . LYS A 1 72  ? -14.627 25.567  30.233 1.00 185.03 ? 104 LYS A CA  1 ? 
ATOM   563  C C   . LYS A 1 72  ? -14.494 27.058  29.922 1.00 197.13 ? 104 LYS A C   1 ? 
ATOM   564  O O   . LYS A 1 72  ? -15.436 27.682  29.435 1.00 198.72 ? 104 LYS A O   1 ? 
ATOM   565  C CB  . LYS A 1 72  ? -15.841 24.903  29.564 1.00 171.04 ? 104 LYS A CB  1 ? 
ATOM   566  C CG  . LYS A 1 72  ? -15.699 24.608  28.070 1.00 168.93 ? 104 LYS A CG  1 ? 
ATOM   567  C CD  . LYS A 1 72  ? -16.290 25.635  27.110 1.00 171.54 ? 104 LYS A CD  1 ? 
ATOM   568  C CE  . LYS A 1 72  ? -15.921 25.397  25.672 1.00 172.96 ? 104 LYS A CE  1 ? 
ATOM   569  N NZ  . LYS A 1 72  ? -14.497 25.620  25.405 1.00 178.19 ? 104 LYS A NZ  1 ? 
ATOM   570  N N   . PRO A 1 73  ? -13.331 27.685  30.224 1.00 200.90 ? 105 PRO A N   1 ? 
ATOM   571  C CA  . PRO A 1 73  ? -13.144 29.123  30.046 1.00 199.64 ? 105 PRO A CA  1 ? 
ATOM   572  C C   . PRO A 1 73  ? -12.094 29.555  29.025 1.00 201.01 ? 105 PRO A C   1 ? 
ATOM   573  O O   . PRO A 1 73  ? -11.021 30.017  29.406 1.00 207.59 ? 105 PRO A O   1 ? 
ATOM   574  C CB  . PRO A 1 73  ? -12.700 29.394  31.499 1.00 200.70 ? 105 PRO A CB  1 ? 
ATOM   575  C CG  . PRO A 1 73  ? -11.844 28.182  31.878 1.00 200.76 ? 105 PRO A CG  1 ? 
ATOM   576  C CD  . PRO A 1 73  ? -12.156 27.086  30.868 1.00 198.67 ? 105 PRO A CD  1 ? 
ATOM   577  N N   . ALA A 1 74  ? -12.413 29.393  27.734 1.00 201.47 ? 106 ALA A N   1 ? 
ATOM   578  C CA  . ALA A 1 74  ? -11.554 29.818  26.636 1.00 203.22 ? 106 ALA A CA  1 ? 
ATOM   579  C C   . ALA A 1 74  ? -10.215 29.078  26.663 1.00 203.08 ? 106 ALA A C   1 ? 
ATOM   580  O O   . ALA A 1 74  ? -9.785  28.563  25.633 1.00 198.90 ? 106 ALA A O   1 ? 
ATOM   581  C CB  . ALA A 1 74  ? -11.366 31.322  26.656 1.00 202.08 ? 106 ALA A CB  1 ? 
ATOM   582  N N   . ILE A 1 75  ? -9.568  29.027  27.840 1.00 202.80 ? 107 ILE A N   1 ? 
ATOM   583  C CA  . ILE A 1 75  ? -8.347  28.257  28.039 1.00 196.04 ? 107 ILE A CA  1 ? 
ATOM   584  C C   . ILE A 1 75  ? -8.615  26.777  27.769 1.00 201.76 ? 107 ILE A C   1 ? 
ATOM   585  O O   . ILE A 1 75  ? -7.694  25.967  27.824 1.00 213.65 ? 107 ILE A O   1 ? 
ATOM   586  C CB  . ILE A 1 75  ? -7.755  28.427  29.455 1.00 179.18 ? 107 ILE A CB  1 ? 
ATOM   587  C CG1 . ILE A 1 75  ? -8.606  27.713  30.519 1.00 166.25 ? 107 ILE A CG1 1 ? 
ATOM   588  C CG2 . ILE A 1 75  ? -7.518  29.901  29.795 1.00 175.32 ? 107 ILE A CG2 1 ? 
ATOM   589  C CD1 . ILE A 1 75  ? -7.812  26.835  31.472 1.00 158.52 ? 107 ILE A CD1 1 ? 
ATOM   590  N N   . ARG A 1 76  ? -9.879  26.418  27.527 1.00 193.45 ? 108 ARG A N   1 ? 
ATOM   591  C CA  . ARG A 1 76  ? -10.206 25.058  27.142 1.00 185.62 ? 108 ARG A CA  1 ? 
ATOM   592  C C   . ARG A 1 76  ? -9.764  24.843  25.696 1.00 178.40 ? 108 ARG A C   1 ? 
ATOM   593  O O   . ARG A 1 76  ? -9.102  23.851  25.400 1.00 181.35 ? 108 ARG A O   1 ? 
ATOM   594  C CB  . ARG A 1 76  ? -11.696 24.780  27.366 1.00 182.26 ? 108 ARG A CB  1 ? 
ATOM   595  C CG  . ARG A 1 76  ? -11.960 23.455  28.064 1.00 179.20 ? 108 ARG A CG  1 ? 
ATOM   596  C CD  . ARG A 1 76  ? -11.356 23.453  29.458 1.00 173.30 ? 108 ARG A CD  1 ? 
ATOM   597  N NE  . ARG A 1 76  ? -12.026 22.509  30.359 1.00 167.91 ? 108 ARG A NE  1 ? 
ATOM   598  C CZ  . ARG A 1 76  ? -11.433 21.680  31.214 1.00 173.37 ? 108 ARG A CZ  1 ? 
ATOM   599  N NH1 . ARG A 1 76  ? -10.113 21.631  31.315 1.00 188.45 ? 108 ARG A NH1 1 ? 
ATOM   600  N NH2 . ARG A 1 76  ? -12.174 20.915  31.997 1.00 163.39 ? 108 ARG A NH2 1 ? 
ATOM   601  N N   . ASN A 1 77  ? -10.089 25.801  24.815 1.00 164.24 ? 109 ASN A N   1 ? 
ATOM   602  C CA  . ASN A 1 77  ? -9.613  25.778  23.439 1.00 151.32 ? 109 ASN A CA  1 ? 
ATOM   603  C C   . ASN A 1 77  ? -8.088  25.705  23.417 1.00 142.85 ? 109 ASN A C   1 ? 
ATOM   604  O O   . ASN A 1 77  ? -7.504  25.495  22.357 1.00 143.18 ? 109 ASN A O   1 ? 
ATOM   605  C CB  . ASN A 1 77  ? -10.107 26.979  22.640 1.00 149.99 ? 109 ASN A CB  1 ? 
ATOM   606  C CG  . ASN A 1 77  ? -11.612 26.992  22.518 1.00 152.59 ? 109 ASN A CG  1 ? 
ATOM   607  O OD1 . ASN A 1 77  ? -12.315 26.767  23.510 1.00 150.21 ? 109 ASN A OD1 1 ? 
ATOM   608  N ND2 . ASN A 1 77  ? -12.124 27.236  21.320 1.00 148.36 ? 109 ASN A ND2 1 ? 
ATOM   609  N N   . GLN A 1 78  ? -7.466  25.921  24.587 1.00 133.34 ? 110 GLN A N   1 ? 
ATOM   610  C CA  . GLN A 1 78  ? -6.053  25.656  24.806 1.00 136.74 ? 110 GLN A CA  1 ? 
ATOM   611  C C   . GLN A 1 78  ? -5.866  24.183  25.161 1.00 133.40 ? 110 GLN A C   1 ? 
ATOM   612  O O   . GLN A 1 78  ? -5.115  23.492  24.479 1.00 137.56 ? 110 GLN A O   1 ? 
ATOM   613  C CB  . GLN A 1 78  ? -5.464  26.619  25.841 1.00 147.18 ? 110 GLN A CB  1 ? 
ATOM   614  C CG  . GLN A 1 78  ? -4.210  26.121  26.555 1.00 151.99 ? 110 GLN A CG  1 ? 
ATOM   615  C CD  . GLN A 1 78  ? -4.500  25.461  27.888 1.00 151.05 ? 110 GLN A CD  1 ? 
ATOM   616  O OE1 . GLN A 1 78  ? -4.949  26.108  28.840 1.00 148.43 ? 110 GLN A OE1 1 ? 
ATOM   617  N NE2 . GLN A 1 78  ? -4.230  24.166  27.979 1.00 154.03 ? 110 GLN A NE2 1 ? 
ATOM   618  N N   . ILE A 1 79  ? -6.548  23.700  26.213 1.00 126.70 ? 111 ILE A N   1 ? 
ATOM   619  C CA  . ILE A 1 79  ? -6.465  22.289  26.578 1.00 128.94 ? 111 ILE A CA  1 ? 
ATOM   620  C C   . ILE A 1 79  ? -6.752  21.423  25.349 1.00 120.04 ? 111 ILE A C   1 ? 
ATOM   621  O O   . ILE A 1 79  ? -6.180  20.346  25.212 1.00 108.12 ? 111 ILE A O   1 ? 
ATOM   622  C CB  . ILE A 1 79  ? -7.391  21.922  27.759 1.00 141.03 ? 111 ILE A CB  1 ? 
ATOM   623  C CG1 . ILE A 1 79  ? -6.715  22.141  29.127 1.00 151.35 ? 111 ILE A CG1 1 ? 
ATOM   624  C CG2 . ILE A 1 79  ? -7.901  20.482  27.639 1.00 135.75 ? 111 ILE A CG2 1 ? 
ATOM   625  C CD1 . ILE A 1 79  ? -6.973  23.497  29.759 1.00 155.44 ? 111 ILE A CD1 1 ? 
ATOM   626  N N   . ILE A 1 80  ? -7.655  21.893  24.477 1.00 114.47 ? 112 ILE A N   1 ? 
ATOM   627  C CA  . ILE A 1 80  ? -8.008  21.208  23.244 1.00 104.49 ? 112 ILE A CA  1 ? 
ATOM   628  C C   . ILE A 1 80  ? -6.843  21.289  22.258 1.00 106.05 ? 112 ILE A C   1 ? 
ATOM   629  O O   . ILE A 1 80  ? -6.604  20.331  21.529 1.00 110.80 ? 112 ILE A O   1 ? 
ATOM   630  C CB  . ILE A 1 80  ? -9.317  21.797  22.674 1.00 108.29 ? 112 ILE A CB  1 ? 
ATOM   631  C CG1 . ILE A 1 80  ? -10.511 21.536  23.609 1.00 110.50 ? 112 ILE A CG1 1 ? 
ATOM   632  C CG2 . ILE A 1 80  ? -9.610  21.317  21.250 1.00 110.00 ? 112 ILE A CG2 1 ? 
ATOM   633  C CD1 . ILE A 1 80  ? -10.776 20.076  23.935 1.00 114.52 ? 112 ILE A CD1 1 ? 
ATOM   634  N N   . ARG A 1 81  ? -6.128  22.424  22.241 1.00 113.84 ? 113 ARG A N   1 ? 
ATOM   635  C CA  . ARG A 1 81  ? -4.987  22.636  21.356 1.00 128.49 ? 113 ARG A CA  1 ? 
ATOM   636  C C   . ARG A 1 81  ? -3.835  21.697  21.720 1.00 125.57 ? 113 ARG A C   1 ? 
ATOM   637  O O   . ARG A 1 81  ? -3.108  21.238  20.839 1.00 116.52 ? 113 ARG A O   1 ? 
ATOM   638  C CB  . ARG A 1 81  ? -4.465  24.079  21.386 1.00 139.97 ? 113 ARG A CB  1 ? 
ATOM   639  C CG  . ARG A 1 81  ? -5.107  25.035  20.390 1.00 151.59 ? 113 ARG A CG  1 ? 
ATOM   640  C CD  . ARG A 1 81  ? -4.431  26.402  20.407 1.00 162.82 ? 113 ARG A CD  1 ? 
ATOM   641  N NE  . ARG A 1 81  ? -4.544  27.109  21.690 1.00 168.37 ? 113 ARG A NE  1 ? 
ATOM   642  C CZ  . ARG A 1 81  ? -3.567  27.325  22.573 1.00 168.50 ? 113 ARG A CZ  1 ? 
ATOM   643  N NH1 . ARG A 1 81  ? -2.392  26.725  22.460 1.00 170.13 ? 113 ARG A NH1 1 ? 
ATOM   644  N NH2 . ARG A 1 81  ? -3.785  28.125  23.602 1.00 162.19 ? 113 ARG A NH2 1 ? 
ATOM   645  N N   . GLU A 1 82  ? -3.668  21.438  23.025 1.00 117.05 ? 114 GLU A N   1 ? 
ATOM   646  C CA  . GLU A 1 82  ? -2.680  20.486  23.506 1.00 115.09 ? 114 GLU A CA  1 ? 
ATOM   647  C C   . GLU A 1 82  ? -3.020  19.099  22.974 1.00 96.96  ? 114 GLU A C   1 ? 
ATOM   648  O O   . GLU A 1 82  ? -2.132  18.357  22.569 1.00 109.10 ? 114 GLU A O   1 ? 
ATOM   649  C CB  . GLU A 1 82  ? -2.612  20.379  25.031 1.00 128.62 ? 114 GLU A CB  1 ? 
ATOM   650  C CG  . GLU A 1 82  ? -2.369  21.701  25.755 1.00 145.27 ? 114 GLU A CG  1 ? 
ATOM   651  C CD  . GLU A 1 82  ? -1.109  22.441  25.346 1.00 156.63 ? 114 GLU A CD  1 ? 
ATOM   652  O OE1 . GLU A 1 82  ? -0.071  21.771  25.149 1.00 162.64 ? 114 GLU A OE1 1 ? 
ATOM   653  O OE2 . GLU A 1 82  ? -1.158  23.687  25.255 1.00 166.19 ? 114 GLU A OE2 1 ? 
ATOM   654  N N   . LEU A 1 83  ? -4.312  18.756  22.994 1.00 93.42  ? 115 LEU A N   1 ? 
ATOM   655  C CA  . LEU A 1 83  ? -4.781  17.488  22.461 1.00 89.64  ? 115 LEU A CA  1 ? 
ATOM   656  C C   . LEU A 1 83  ? -4.619  17.479  20.943 1.00 89.36  ? 115 LEU A C   1 ? 
ATOM   657  O O   . LEU A 1 83  ? -4.436  16.415  20.364 1.00 103.77 ? 115 LEU A O   1 ? 
ATOM   658  C CB  . LEU A 1 83  ? -6.230  17.223  22.864 1.00 92.58  ? 115 LEU A CB  1 ? 
ATOM   659  C CG  . LEU A 1 83  ? -6.507  17.097  24.367 1.00 98.37  ? 115 LEU A CG  1 ? 
ATOM   660  C CD1 . LEU A 1 83  ? -7.991  17.258  24.678 1.00 104.66 ? 115 LEU A CD1 1 ? 
ATOM   661  C CD2 . LEU A 1 83  ? -6.012  15.780  24.916 1.00 94.54  ? 115 LEU A CD2 1 ? 
ATOM   662  N N   . GLN A 1 84  ? -4.665  18.659  20.308 1.00 99.88  ? 116 GLN A N   1 ? 
ATOM   663  C CA  . GLN A 1 84  ? -4.510  18.772  18.862 1.00 112.80 ? 116 GLN A CA  1 ? 
ATOM   664  C C   . GLN A 1 84  ? -3.093  18.406  18.422 1.00 112.05 ? 116 GLN A C   1 ? 
ATOM   665  O O   . GLN A 1 84  ? -2.828  18.359  17.224 1.00 119.49 ? 116 GLN A O   1 ? 
ATOM   666  C CB  . GLN A 1 84  ? -4.771  20.174  18.297 1.00 122.54 ? 116 GLN A CB  1 ? 
ATOM   667  C CG  . GLN A 1 84  ? -6.163  20.730  18.568 1.00 124.48 ? 116 GLN A CG  1 ? 
ATOM   668  C CD  . GLN A 1 84  ? -7.261  19.867  17.992 1.00 130.79 ? 116 GLN A CD  1 ? 
ATOM   669  O OE1 . GLN A 1 84  ? -7.508  19.864  16.781 1.00 143.09 ? 116 GLN A OE1 1 ? 
ATOM   670  N NE2 . GLN A 1 84  ? -7.927  19.118  18.859 1.00 128.29 ? 116 GLN A NE2 1 ? 
ATOM   671  N N   . VAL A 1 85  ? -2.183  18.156  19.372 1.00 107.93 ? 117 VAL A N   1 ? 
ATOM   672  C CA  . VAL A 1 85  ? -0.832  17.735  19.035 1.00 113.06 ? 117 VAL A CA  1 ? 
ATOM   673  C C   . VAL A 1 85  ? -0.825  16.253  18.638 1.00 120.02 ? 117 VAL A C   1 ? 
ATOM   674  O O   . VAL A 1 85  ? 0.133   15.793  18.019 1.00 120.69 ? 117 VAL A O   1 ? 
ATOM   675  C CB  . VAL A 1 85  ? 0.143   18.053  20.186 1.00 119.40 ? 117 VAL A CB  1 ? 
ATOM   676  C CG1 . VAL A 1 85  ? 1.584   17.685  19.848 1.00 129.64 ? 117 VAL A CG1 1 ? 
ATOM   677  C CG2 . VAL A 1 85  ? 0.077   19.526  20.580 1.00 117.39 ? 117 VAL A CG2 1 ? 
ATOM   678  N N   . LEU A 1 86  ? -1.906  15.515  18.949 1.00 123.82 ? 118 LEU A N   1 ? 
ATOM   679  C CA  . LEU A 1 86  ? -2.086  14.146  18.472 1.00 111.75 ? 118 LEU A CA  1 ? 
ATOM   680  C C   . LEU A 1 86  ? -2.237  14.144  16.949 1.00 109.68 ? 118 LEU A C   1 ? 
ATOM   681  O O   . LEU A 1 86  ? -1.990  13.119  16.319 1.00 104.19 ? 118 LEU A O   1 ? 
ATOM   682  C CB  . LEU A 1 86  ? -3.273  13.443  19.137 1.00 102.43 ? 118 LEU A CB  1 ? 
ATOM   683  C CG  . LEU A 1 86  ? -3.292  13.458  20.671 1.00 107.41 ? 118 LEU A CG  1 ? 
ATOM   684  C CD1 . LEU A 1 86  ? -4.306  12.475  21.260 1.00 101.11 ? 118 LEU A CD1 1 ? 
ATOM   685  C CD2 . LEU A 1 86  ? -1.888  13.210  21.218 1.00 108.76 ? 118 LEU A CD2 1 ? 
ATOM   686  N N   . HIS A 1 87  ? -2.674  15.283  16.380 1.00 113.65 ? 119 HIS A N   1 ? 
ATOM   687  C CA  . HIS A 1 87  ? -2.694  15.503  14.939 1.00 111.20 ? 119 HIS A CA  1 ? 
ATOM   688  C C   . HIS A 1 87  ? -1.249  15.558  14.432 1.00 113.61 ? 119 HIS A C   1 ? 
ATOM   689  O O   . HIS A 1 87  ? -1.062  15.432  13.203 1.00 112.98 ? 119 HIS A O   1 ? 
ATOM   690  C CB  . HIS A 1 87  ? -3.362  16.832  14.545 1.00 111.74 ? 119 HIS A CB  1 ? 
ATOM   691  C CG  . HIS A 1 87  ? -4.862  16.902  14.524 1.00 123.21 ? 119 HIS A CG  1 ? 
ATOM   692  N ND1 . HIS A 1 87  ? -5.688  16.057  13.811 1.00 131.73 ? 119 HIS A ND1 1 ? 
ATOM   693  C CD2 . HIS A 1 87  ? -5.679  17.818  15.082 1.00 129.63 ? 119 HIS A CD2 1 ? 
ATOM   694  C CE1 . HIS A 1 87  ? -6.954  16.428  13.983 1.00 132.07 ? 119 HIS A CE1 1 ? 
ATOM   695  N NE2 . HIS A 1 87  ? -6.973  17.495  14.751 1.00 127.48 ? 119 HIS A NE2 1 ? 
ATOM   696  N N   . CYS A 1 89  ? 0.503   13.054  14.725 1.00 93.52  ? 121 CYS A N   1 ? 
ATOM   697  C CA  . CYS A 1 89  ? 1.034   11.706  14.386 1.00 86.73  ? 121 CYS A CA  1 ? 
ATOM   698  C C   . CYS A 1 89  ? 0.613   11.319  12.972 1.00 84.86  ? 121 CYS A C   1 ? 
ATOM   699  O O   . CYS A 1 89  ? -0.558  11.418  12.608 1.00 73.19  ? 121 CYS A O   1 ? 
ATOM   700  C CB  . CYS A 1 89  ? 0.563   10.653  15.379 1.00 85.41  ? 121 CYS A CB  1 ? 
ATOM   701  S SG  . CYS A 1 89  ? 1.292   10.833  17.030 1.00 96.85  ? 121 CYS A SG  1 ? 
ATOM   702  N N   . ASN A 1 90  ? 1.601   10.906  12.176 1.00 84.49  ? 122 ASN A N   1 ? 
ATOM   703  C CA  . ASN A 1 90  ? 1.359   10.317  10.873 1.00 86.03  ? 122 ASN A CA  1 ? 
ATOM   704  C C   . ASN A 1 90  ? 2.266   9.091   10.777 1.00 85.68  ? 122 ASN A C   1 ? 
ATOM   705  O O   . ASN A 1 90  ? 3.336   9.161   10.178 1.00 81.66  ? 122 ASN A O   1 ? 
ATOM   706  C CB  . ASN A 1 90  ? 1.540   11.356  9.769  1.00 91.44  ? 122 ASN A CB  1 ? 
ATOM   707  C CG  . ASN A 1 90  ? 1.003   10.887  8.439  1.00 99.94  ? 122 ASN A CG  1 ? 
ATOM   708  O OD1 . ASN A 1 90  ? 1.737   10.862  7.444  1.00 90.55  ? 122 ASN A OD1 1 ? 
ATOM   709  N ND2 . ASN A 1 90  ? -0.271  10.525  8.392  1.00 114.07 ? 122 ASN A ND2 1 ? 
ATOM   710  N N   . SER A 1 91  ? 1.842   8.002   11.445 1.00 85.11  ? 123 SER A N   1 ? 
ATOM   711  C CA  . SER A 1 91  ? 2.591   6.755   11.531 1.00 71.11  ? 123 SER A CA  1 ? 
ATOM   712  C C   . SER A 1 91  ? 1.652   5.573   11.330 1.00 72.91  ? 123 SER A C   1 ? 
ATOM   713  O O   . SER A 1 91  ? 0.537   5.573   11.843 1.00 81.48  ? 123 SER A O   1 ? 
ATOM   714  C CB  . SER A 1 91  ? 3.297   6.604   12.844 1.00 67.32  ? 123 SER A CB  1 ? 
ATOM   715  O OG  . SER A 1 91  ? 3.798   5.275   12.987 1.00 65.57  ? 123 SER A OG  1 ? 
ATOM   716  N N   . PRO A 1 92  ? 2.065   4.520   10.593 1.00 73.04  ? 124 PRO A N   1 ? 
ATOM   717  C CA  . PRO A 1 92  ? 1.256   3.305   10.504 1.00 71.37  ? 124 PRO A CA  1 ? 
ATOM   718  C C   . PRO A 1 92  ? 1.189   2.534   11.823 1.00 69.29  ? 124 PRO A C   1 ? 
ATOM   719  O O   . PRO A 1 92  ? 0.325   1.669   11.987 1.00 67.45  ? 124 PRO A O   1 ? 
ATOM   720  C CB  . PRO A 1 92  ? 1.945   2.501   9.386  1.00 67.57  ? 124 PRO A CB  1 ? 
ATOM   721  C CG  . PRO A 1 92  ? 2.815   3.518   8.666  1.00 70.48  ? 124 PRO A CG  1 ? 
ATOM   722  C CD  . PRO A 1 92  ? 3.274   4.458   9.759  1.00 69.44  ? 124 PRO A CD  1 ? 
ATOM   723  N N   . TYR A 1 93  ? 2.090   2.855   12.762 1.00 59.94  ? 125 TYR A N   1 ? 
ATOM   724  C CA  . TYR A 1 93  ? 2.165   2.115   14.013 1.00 63.90  ? 125 TYR A CA  1 ? 
ATOM   725  C C   . TYR A 1 93  ? 1.564   2.951   15.130 1.00 57.89  ? 125 TYR A C   1 ? 
ATOM   726  O O   . TYR A 1 93  ? 1.748   2.617   16.293 1.00 63.40  ? 125 TYR A O   1 ? 
ATOM   727  C CB  . TYR A 1 93  ? 3.602   1.660   14.308 1.00 71.40  ? 125 TYR A CB  1 ? 
ATOM   728  C CG  . TYR A 1 93  ? 4.188   0.970   13.085 1.00 74.69  ? 125 TYR A CG  1 ? 
ATOM   729  C CD1 . TYR A 1 93  ? 3.677   -0.241  12.641 1.00 67.03  ? 125 TYR A CD1 1 ? 
ATOM   730  C CD2 . TYR A 1 93  ? 5.183   1.574   12.326 1.00 85.62  ? 125 TYR A CD2 1 ? 
ATOM   731  C CE1 . TYR A 1 93  ? 4.159   -0.850  11.495 1.00 74.35  ? 125 TYR A CE1 1 ? 
ATOM   732  C CE2 . TYR A 1 93  ? 5.679   0.975   11.179 1.00 79.09  ? 125 TYR A CE2 1 ? 
ATOM   733  C CZ  . TYR A 1 93  ? 5.168   -0.240  10.769 1.00 77.09  ? 125 TYR A CZ  1 ? 
ATOM   734  O OH  . TYR A 1 93  ? 5.652   -0.816  9.640  1.00 77.10  ? 125 TYR A OH  1 ? 
ATOM   735  N N   . ILE A 1 94  ? 0.850   4.021   14.757 1.00 63.78  ? 126 ILE A N   1 ? 
ATOM   736  C CA  . ILE A 1 94  ? 0.194   4.899   15.714 1.00 65.85  ? 126 ILE A CA  1 ? 
ATOM   737  C C   . ILE A 1 94  ? -1.262  5.082   15.292 1.00 71.80  ? 126 ILE A C   1 ? 
ATOM   738  O O   . ILE A 1 94  ? -1.559  5.318   14.112 1.00 61.90  ? 126 ILE A O   1 ? 
ATOM   739  C CB  . ILE A 1 94  ? 0.921   6.248   15.836 1.00 68.85  ? 126 ILE A CB  1 ? 
ATOM   740  C CG1 . ILE A 1 94  ? 2.379   6.097   16.291 1.00 68.96  ? 126 ILE A CG1 1 ? 
ATOM   741  C CG2 . ILE A 1 94  ? 0.149   7.195   16.749 1.00 68.89  ? 126 ILE A CG2 1 ? 
ATOM   742  C CD1 . ILE A 1 94  ? 2.549   5.602   17.715 1.00 77.30  ? 126 ILE A CD1 1 ? 
ATOM   743  N N   . VAL A 1 95  ? -2.158  4.945   16.282 1.00 70.67  ? 127 VAL A N   1 ? 
ATOM   744  C CA  . VAL A 1 95  ? -3.592  5.009   16.053 1.00 67.77  ? 127 VAL A CA  1 ? 
ATOM   745  C C   . VAL A 1 95  ? -3.926  6.398   15.517 1.00 61.85  ? 127 VAL A C   1 ? 
ATOM   746  O O   . VAL A 1 95  ? -3.411  7.399   16.014 1.00 67.74  ? 127 VAL A O   1 ? 
ATOM   747  C CB  . VAL A 1 95  ? -4.390  4.684   17.333 1.00 67.42  ? 127 VAL A CB  1 ? 
ATOM   748  C CG1 . VAL A 1 95  ? -5.882  4.986   17.194 1.00 68.01  ? 127 VAL A CG1 1 ? 
ATOM   749  C CG2 . VAL A 1 95  ? -4.187  3.236   17.765 1.00 63.53  ? 127 VAL A CG2 1 ? 
ATOM   750  N N   . GLY A 1 96  ? -4.779  6.433   14.490 1.00 53.05  ? 128 GLY A N   1 ? 
ATOM   751  C CA  . GLY A 1 96  ? -5.224  7.683   13.888 1.00 62.08  ? 128 GLY A CA  1 ? 
ATOM   752  C C   . GLY A 1 96  ? -6.079  8.534   14.830 1.00 69.44  ? 128 GLY A C   1 ? 
ATOM   753  O O   . GLY A 1 96  ? -6.853  8.009   15.627 1.00 75.63  ? 128 GLY A O   1 ? 
ATOM   754  N N   . PHE A 1 97  ? -5.935  9.861   14.716 1.00 70.00  ? 129 PHE A N   1 ? 
ATOM   755  C CA  . PHE A 1 97  ? -6.670  10.815  15.531 1.00 71.12  ? 129 PHE A CA  1 ? 
ATOM   756  C C   . PHE A 1 97  ? -7.525  11.686  14.623 1.00 69.44  ? 129 PHE A C   1 ? 
ATOM   757  O O   . PHE A 1 97  ? -7.029  12.189  13.624 1.00 69.44  ? 129 PHE A O   1 ? 
ATOM   758  C CB  . PHE A 1 97  ? -5.645  11.640  16.310 1.00 75.12  ? 129 PHE A CB  1 ? 
ATOM   759  C CG  . PHE A 1 97  ? -6.182  12.831  17.088 1.00 83.32  ? 129 PHE A CG  1 ? 
ATOM   760  C CD1 . PHE A 1 97  ? -6.900  12.651  18.261 1.00 85.33  ? 129 PHE A CD1 1 ? 
ATOM   761  C CD2 . PHE A 1 97  ? -5.908  14.131  16.676 1.00 90.25  ? 129 PHE A CD2 1 ? 
ATOM   762  C CE1 . PHE A 1 97  ? -7.358  13.743  18.982 1.00 89.70  ? 129 PHE A CE1 1 ? 
ATOM   763  C CE2 . PHE A 1 97  ? -6.363  15.219  17.406 1.00 87.51  ? 129 PHE A CE2 1 ? 
ATOM   764  C CZ  . PHE A 1 97  ? -7.089  15.021  18.555 1.00 91.52  ? 129 PHE A CZ  1 ? 
ATOM   765  N N   . TYR A 1 98  ? -8.806  11.837  14.971 1.00 76.86  ? 130 TYR A N   1 ? 
ATOM   766  C CA  . TYR A 1 98  ? -9.743  12.646  14.201 1.00 66.20  ? 130 TYR A CA  1 ? 
ATOM   767  C C   . TYR A 1 98  ? -9.848  14.068  14.759 1.00 67.95  ? 130 TYR A C   1 ? 
ATOM   768  O O   . TYR A 1 98  ? -9.851  15.029  14.003 1.00 65.34  ? 130 TYR A O   1 ? 
ATOM   769  C CB  . TYR A 1 98  ? -11.110 11.972  14.252 1.00 64.14  ? 130 TYR A CB  1 ? 
ATOM   770  C CG  . TYR A 1 98  ? -11.210 10.719  13.405 1.00 63.32  ? 130 TYR A CG  1 ? 
ATOM   771  C CD1 . TYR A 1 98  ? -11.153 10.793  12.022 1.00 64.14  ? 130 TYR A CD1 1 ? 
ATOM   772  C CD2 . TYR A 1 98  ? -11.398 9.478   13.983 1.00 65.44  ? 130 TYR A CD2 1 ? 
ATOM   773  C CE1 . TYR A 1 98  ? -11.261 9.664   11.234 1.00 67.21  ? 130 TYR A CE1 1 ? 
ATOM   774  C CE2 . TYR A 1 98  ? -11.510 8.339   13.203 1.00 70.59  ? 130 TYR A CE2 1 ? 
ATOM   775  C CZ  . TYR A 1 98  ? -11.443 8.430   11.826 1.00 66.58  ? 130 TYR A CZ  1 ? 
ATOM   776  O OH  . TYR A 1 98  ? -11.562 7.305   11.055 1.00 72.17  ? 130 TYR A OH  1 ? 
ATOM   777  N N   . GLY A 1 99  ? -9.988  14.205  16.081 1.00 71.03  ? 131 GLY A N   1 ? 
ATOM   778  C CA  . GLY A 1 99  ? -10.022 15.514  16.709 1.00 79.61  ? 131 GLY A CA  1 ? 
ATOM   779  C C   . GLY A 1 99  ? -10.435 15.415  18.174 1.00 79.20  ? 131 GLY A C   1 ? 
ATOM   780  O O   . GLY A 1 99  ? -10.609 14.324  18.702 1.00 73.47  ? 131 GLY A O   1 ? 
ATOM   781  N N   . ALA A 1 100 ? -10.582 16.566  18.829 1.00 79.18  ? 132 ALA A N   1 ? 
ATOM   782  C CA  . ALA A 1 100 ? -11.032 16.584  20.208 1.00 85.10  ? 132 ALA A CA  1 ? 
ATOM   783  C C   . ALA A 1 100 ? -11.882 17.822  20.457 1.00 83.46  ? 132 ALA A C   1 ? 
ATOM   784  O O   . ALA A 1 100 ? -11.632 18.868  19.870 1.00 84.91  ? 132 ALA A O   1 ? 
ATOM   785  C CB  . ALA A 1 100 ? -9.838  16.526  21.137 1.00 90.29  ? 132 ALA A CB  1 ? 
ATOM   786  N N   . PHE A 1 101 ? -12.863 17.694  21.358 1.00 88.65  ? 133 PHE A N   1 ? 
ATOM   787  C CA  . PHE A 1 101 ? -13.732 18.804  21.713 1.00 91.52  ? 133 PHE A CA  1 ? 
ATOM   788  C C   . PHE A 1 101 ? -14.154 18.714  23.180 1.00 98.83  ? 133 PHE A C   1 ? 
ATOM   789  O O   . PHE A 1 101 ? -13.872 17.734  23.871 1.00 95.92  ? 133 PHE A O   1 ? 
ATOM   790  C CB  . PHE A 1 101 ? -14.926 18.823  20.752 1.00 87.95  ? 133 PHE A CB  1 ? 
ATOM   791  C CG  . PHE A 1 101 ? -15.786 17.566  20.729 1.00 92.95  ? 133 PHE A CG  1 ? 
ATOM   792  C CD1 . PHE A 1 101 ? -16.837 17.400  21.627 1.00 94.31  ? 133 PHE A CD1 1 ? 
ATOM   793  C CD2 . PHE A 1 101 ? -15.560 16.565  19.791 1.00 94.10  ? 133 PHE A CD2 1 ? 
ATOM   794  C CE1 . PHE A 1 101 ? -17.629 16.262  21.593 1.00 95.07  ? 133 PHE A CE1 1 ? 
ATOM   795  C CE2 . PHE A 1 101 ? -16.353 15.428  19.763 1.00 93.84  ? 133 PHE A CE2 1 ? 
ATOM   796  C CZ  . PHE A 1 101 ? -17.383 15.275  20.662 1.00 96.66  ? 133 PHE A CZ  1 ? 
ATOM   797  N N   . TYR A 1 102 ? -14.824 19.779  23.639 1.00 105.10 ? 134 TYR A N   1 ? 
ATOM   798  C CA  . TYR A 1 102 ? -15.455 19.815  24.947 1.00 104.43 ? 134 TYR A CA  1 ? 
ATOM   799  C C   . TYR A 1 102 ? -16.968 19.780  24.765 1.00 100.56 ? 134 TYR A C   1 ? 
ATOM   800  O O   . TYR A 1 102 ? -17.479 20.250  23.752 1.00 106.80 ? 134 TYR A O   1 ? 
ATOM   801  C CB  . TYR A 1 102 ? -15.063 21.077  25.715 1.00 109.84 ? 134 TYR A CB  1 ? 
ATOM   802  C CG  . TYR A 1 102 ? -15.314 20.992  27.213 1.00 121.77 ? 134 TYR A CG  1 ? 
ATOM   803  C CD1 . TYR A 1 102 ? -16.539 21.347  27.765 1.00 131.23 ? 134 TYR A CD1 1 ? 
ATOM   804  C CD2 . TYR A 1 102 ? -14.316 20.557  28.075 1.00 131.29 ? 134 TYR A CD2 1 ? 
ATOM   805  C CE1 . TYR A 1 102 ? -16.759 21.282  29.131 1.00 136.70 ? 134 TYR A CE1 1 ? 
ATOM   806  C CE2 . TYR A 1 102 ? -14.524 20.483  29.441 1.00 137.44 ? 134 TYR A CE2 1 ? 
ATOM   807  C CZ  . TYR A 1 102 ? -15.748 20.849  29.970 1.00 138.66 ? 134 TYR A CZ  1 ? 
ATOM   808  O OH  . TYR A 1 102 ? -15.949 20.779  31.316 1.00 145.10 ? 134 TYR A OH  1 ? 
ATOM   809  N N   . SER A 1 103 ? -17.667 19.191  25.740 1.00 96.87  ? 135 SER A N   1 ? 
ATOM   810  C CA  . SER A 1 103 ? -19.118 19.232  25.774 1.00 103.34 ? 135 SER A CA  1 ? 
ATOM   811  C C   . SER A 1 103 ? -19.589 18.656  27.103 1.00 113.16 ? 135 SER A C   1 ? 
ATOM   812  O O   . SER A 1 103 ? -19.118 17.597  27.516 1.00 113.94 ? 135 SER A O   1 ? 
ATOM   813  C CB  . SER A 1 103 ? -19.760 18.496  24.613 1.00 101.33 ? 135 SER A CB  1 ? 
ATOM   814  O OG  . SER A 1 103 ? -20.225 17.209  25.003 1.00 104.56 ? 135 SER A OG  1 ? 
ATOM   815  N N   . ASP A 1 104 ? -20.500 19.393  27.754 1.00 117.90 ? 136 ASP A N   1 ? 
ATOM   816  C CA  . ASP A 1 104 ? -21.255 18.916  28.901 1.00 109.76 ? 136 ASP A CA  1 ? 
ATOM   817  C C   . ASP A 1 104 ? -20.290 18.412  29.974 1.00 106.53 ? 136 ASP A C   1 ? 
ATOM   818  O O   . ASP A 1 104 ? -20.490 17.338  30.545 1.00 102.06 ? 136 ASP A O   1 ? 
ATOM   819  C CB  . ASP A 1 104 ? -22.316 17.922  28.451 1.00 109.07 ? 136 ASP A CB  1 ? 
ATOM   820  C CG  . ASP A 1 104 ? -23.304 18.445  27.414 1.00 120.53 ? 136 ASP A CG  1 ? 
ATOM   821  O OD1 . ASP A 1 104 ? -22.870 19.203  26.515 1.00 115.36 ? 136 ASP A OD1 1 ? 
ATOM   822  O OD2 . ASP A 1 104 ? -24.497 18.068  27.490 1.00 129.29 ? 136 ASP A OD2 1 ? 
ATOM   823  N N   . GLY A 1 105 ? -19.252 19.216  30.244 1.00 98.76  ? 137 GLY A N   1 ? 
ATOM   824  C CA  . GLY A 1 105 ? -18.252 18.889  31.249 1.00 112.33 ? 137 GLY A CA  1 ? 
ATOM   825  C C   . GLY A 1 105 ? -17.514 17.587  30.933 1.00 119.87 ? 137 GLY A C   1 ? 
ATOM   826  O O   . GLY A 1 105 ? -17.263 16.789  31.835 1.00 111.06 ? 137 GLY A O   1 ? 
ATOM   827  N N   . GLU A 1 106 ? -17.164 17.384  29.653 1.00 121.72 ? 138 GLU A N   1 ? 
ATOM   828  C CA  . GLU A 1 106 ? -16.637 16.107  29.197 1.00 114.54 ? 138 GLU A CA  1 ? 
ATOM   829  C C   . GLU A 1 106 ? -15.731 16.326  27.986 1.00 103.23 ? 138 GLU A C   1 ? 
ATOM   830  O O   . GLU A 1 106 ? -16.203 16.746  26.929 1.00 103.88 ? 138 GLU A O   1 ? 
ATOM   831  C CB  . GLU A 1 106 ? -17.782 15.158  28.829 1.00 120.30 ? 138 GLU A CB  1 ? 
ATOM   832  C CG  . GLU A 1 106 ? -17.628 13.749  29.397 1.00 131.13 ? 138 GLU A CG  1 ? 
ATOM   833  C CD  . GLU A 1 106 ? -18.305 13.498  30.736 1.00 144.05 ? 138 GLU A CD  1 ? 
ATOM   834  O OE1 . GLU A 1 106 ? -18.052 12.430  31.334 1.00 141.92 ? 138 GLU A OE1 1 ? 
ATOM   835  O OE2 . GLU A 1 106 ? -19.106 14.350  31.177 1.00 159.13 ? 138 GLU A OE2 1 ? 
ATOM   836  N N   . ILE A 1 107 ? -14.434 16.035  28.167 1.00 92.67  ? 139 ILE A N   1 ? 
ATOM   837  C CA  . ILE A 1 107 ? -13.454 15.953  27.089 1.00 96.85  ? 139 ILE A CA  1 ? 
ATOM   838  C C   . ILE A 1 107 ? -13.791 14.786  26.155 1.00 95.08  ? 139 ILE A C   1 ? 
ATOM   839  O O   . ILE A 1 107 ? -13.938 13.653  26.612 1.00 90.27  ? 139 ILE A O   1 ? 
ATOM   840  C CB  . ILE A 1 107 ? -12.033 15.773  27.666 1.00 98.69  ? 139 ILE A CB  1 ? 
ATOM   841  C CG1 . ILE A 1 107 ? -11.499 17.032  28.354 1.00 98.45  ? 139 ILE A CG1 1 ? 
ATOM   842  C CG2 . ILE A 1 107 ? -11.062 15.284  26.588 1.00 102.29 ? 139 ILE A CG2 1 ? 
ATOM   843  C CD1 . ILE A 1 107 ? -11.166 18.172  27.406 1.00 107.93 ? 139 ILE A CD1 1 ? 
ATOM   844  N N   . SER A 1 108 ? -13.872 15.057  24.843 1.00 82.30  ? 140 SER A N   1 ? 
ATOM   845  C CA  . SER A 1 108 ? -13.967 14.006  23.842 1.00 81.54  ? 140 SER A CA  1 ? 
ATOM   846  C C   . SER A 1 108 ? -12.707 13.991  22.983 1.00 79.93  ? 140 SER A C   1 ? 
ATOM   847  O O   . SER A 1 108 ? -12.269 15.032  22.515 1.00 77.89  ? 140 SER A O   1 ? 
ATOM   848  C CB  . SER A 1 108 ? -15.203 14.133  22.982 1.00 86.14  ? 140 SER A CB  1 ? 
ATOM   849  O OG  . SER A 1 108 ? -16.201 13.192  23.360 1.00 86.25  ? 140 SER A OG  1 ? 
ATOM   850  N N   . ILE A 1 109 ? -12.150 12.786  22.802 1.00 85.74  ? 141 ILE A N   1 ? 
ATOM   851  C CA  . ILE A 1 109 ? -11.009 12.513  21.944 1.00 80.40  ? 141 ILE A CA  1 ? 
ATOM   852  C C   . ILE A 1 109 ? -11.407 11.380  20.997 1.00 77.10  ? 141 ILE A C   1 ? 
ATOM   853  O O   . ILE A 1 109 ? -11.585 10.248  21.440 1.00 75.84  ? 141 ILE A O   1 ? 
ATOM   854  C CB  . ILE A 1 109 ? -9.782  12.115  22.789 1.00 84.63  ? 141 ILE A CB  1 ? 
ATOM   855  C CG1 . ILE A 1 109 ? -9.504  13.096  23.925 1.00 81.94  ? 141 ILE A CG1 1 ? 
ATOM   856  C CG2 . ILE A 1 109 ? -8.551  11.911  21.905 1.00 86.21  ? 141 ILE A CG2 1 ? 
ATOM   857  C CD1 . ILE A 1 109 ? -8.282  12.742  24.759 1.00 79.60  ? 141 ILE A CD1 1 ? 
ATOM   858  N N   . CYS A 1 110 ? -11.524 11.685  19.700 1.00 73.68  ? 142 CYS A N   1 ? 
ATOM   859  C CA  . CYS A 1 110 ? -12.060 10.753  18.723 1.00 72.13  ? 142 CYS A CA  1 ? 
ATOM   860  C C   . CYS A 1 110 ? -10.934 10.133  17.901 1.00 78.74  ? 142 CYS A C   1 ? 
ATOM   861  O O   . CYS A 1 110 ? -10.203 10.840  17.208 1.00 77.35  ? 142 CYS A O   1 ? 
ATOM   862  C CB  . CYS A 1 110 ? -13.061 11.452  17.817 1.00 79.38  ? 142 CYS A CB  1 ? 
ATOM   863  S SG  . CYS A 1 110 ? -14.479 12.107  18.733 1.00 86.99  ? 142 CYS A SG  1 ? 
ATOM   864  N N   . MET A 1 111 ? -10.833 8.797   17.960 1.00 70.42  ? 143 MET A N   1 ? 
ATOM   865  C CA  . MET A 1 111 ? -9.719  8.085   17.366 1.00 62.35  ? 143 MET A CA  1 ? 
ATOM   866  C C   . MET A 1 111 ? -10.248 7.153   16.290 1.00 67.77  ? 143 MET A C   1 ? 
ATOM   867  O O   . MET A 1 111 ? -11.462 7.041   16.129 1.00 60.16  ? 143 MET A O   1 ? 
ATOM   868  C CB  . MET A 1 111 ? -9.005  7.270   18.432 1.00 69.10  ? 143 MET A CB  1 ? 
ATOM   869  C CG  . MET A 1 111 ? -8.558  8.097   19.596 1.00 76.47  ? 143 MET A CG  1 ? 
ATOM   870  S SD  . MET A 1 111 ? -6.983  8.897   19.280 1.00 95.52  ? 143 MET A SD  1 ? 
ATOM   871  C CE  . MET A 1 111 ? -6.484  8.824   21.006 1.00 93.79  ? 143 MET A CE  1 ? 
ATOM   872  N N   . GLU A 1 112 ? -9.328  6.500   15.563 1.00 70.46  ? 144 GLU A N   1 ? 
ATOM   873  C CA  . GLU A 1 112 ? -9.724  5.541   14.544 1.00 76.03  ? 144 GLU A CA  1 ? 
ATOM   874  C C   . GLU A 1 112 ? -10.228 4.293   15.266 1.00 73.29  ? 144 GLU A C   1 ? 
ATOM   875  O O   . GLU A 1 112 ? -9.681  3.902   16.293 1.00 73.20  ? 144 GLU A O   1 ? 
ATOM   876  C CB  . GLU A 1 112 ? -8.643  5.319   13.478 1.00 69.98  ? 144 GLU A CB  1 ? 
ATOM   877  C CG  . GLU A 1 112 ? -7.804  4.052   13.619 1.00 76.34  ? 144 GLU A CG  1 ? 
ATOM   878  C CD  . GLU A 1 112 ? -6.584  3.997   12.704 1.00 73.77  ? 144 GLU A CD  1 ? 
ATOM   879  O OE1 . GLU A 1 112 ? -5.654  4.798   12.943 1.00 73.53  ? 144 GLU A OE1 1 ? 
ATOM   880  O OE2 . GLU A 1 112 ? -6.534  3.168   11.768 1.00 61.34  ? 144 GLU A OE2 1 ? 
ATOM   881  N N   . HIS A 1 113 ? -11.332 3.747   14.754 1.00 70.25  ? 145 HIS A N   1 ? 
ATOM   882  C CA  . HIS A 1 113 ? -11.908 2.519   15.262 1.00 68.86  ? 145 HIS A CA  1 ? 
ATOM   883  C C   . HIS A 1 113 ? -11.008 1.352   14.872 1.00 67.10  ? 145 HIS A C   1 ? 
ATOM   884  O O   . HIS A 1 113 ? -10.956 0.973   13.697 1.00 58.40  ? 145 HIS A O   1 ? 
ATOM   885  C CB  . HIS A 1 113 ? -13.305 2.279   14.670 1.00 68.69  ? 145 HIS A CB  1 ? 
ATOM   886  C CG  . HIS A 1 113 ? -13.916 1.000   15.141 1.00 69.18  ? 145 HIS A CG  1 ? 
ATOM   887  N ND1 . HIS A 1 113 ? -14.499 0.075   14.301 1.00 65.93  ? 145 HIS A ND1 1 ? 
ATOM   888  C CD2 . HIS A 1 113 ? -13.978 0.482   16.381 1.00 63.55  ? 145 HIS A CD2 1 ? 
ATOM   889  C CE1 . HIS A 1 113 ? -14.912 -0.958  15.025 1.00 66.50  ? 145 HIS A CE1 1 ? 
ATOM   890  N NE2 . HIS A 1 113 ? -14.607 -0.727  16.290 1.00 66.75  ? 145 HIS A NE2 1 ? 
ATOM   891  N N   . MET A 1 114 ? -10.333 0.769   15.870 1.00 65.91  ? 146 MET A N   1 ? 
ATOM   892  C CA  . MET A 1 114 ? -9.580  -0.458  15.653 1.00 71.05  ? 146 MET A CA  1 ? 
ATOM   893  C C   . MET A 1 114 ? -10.481 -1.640  16.017 1.00 70.91  ? 146 MET A C   1 ? 
ATOM   894  O O   . MET A 1 114 ? -10.897 -1.778  17.163 1.00 69.83  ? 146 MET A O   1 ? 
ATOM   895  C CB  . MET A 1 114 ? -8.269  -0.433  16.451 1.00 71.38  ? 146 MET A CB  1 ? 
ATOM   896  C CG  . MET A 1 114 ? -7.317  0.696   16.048 1.00 71.66  ? 146 MET A CG  1 ? 
ATOM   897  S SD  . MET A 1 114 ? -6.658  0.573   14.370 1.00 66.59  ? 146 MET A SD  1 ? 
ATOM   898  C CE  . MET A 1 114 ? -5.398  -0.679  14.623 1.00 64.46  ? 146 MET A CE  1 ? 
ATOM   899  N N   . ASP A 1 115 ? -10.817 -2.469  15.022 1.00 69.91  ? 147 ASP A N   1 ? 
ATOM   900  C CA  . ASP A 1 115 ? -11.920 -3.413  15.145 1.00 66.70  ? 147 ASP A CA  1 ? 
ATOM   901  C C   . ASP A 1 115 ? -11.515 -4.637  15.976 1.00 68.47  ? 147 ASP A C   1 ? 
ATOM   902  O O   . ASP A 1 115 ? -12.374 -5.335  16.492 1.00 70.01  ? 147 ASP A O   1 ? 
ATOM   903  C CB  . ASP A 1 115 ? -12.495 -3.774  13.782 1.00 63.22  ? 147 ASP A CB  1 ? 
ATOM   904  C CG  . ASP A 1 115 ? -11.616 -4.655  12.908 1.00 69.62  ? 147 ASP A CG  1 ? 
ATOM   905  O OD1 . ASP A 1 115 ? -10.442 -4.863  13.281 1.00 72.09  ? 147 ASP A OD1 1 ? 
ATOM   906  O OD2 . ASP A 1 115 ? -12.120 -5.156  11.876 1.00 67.97  ? 147 ASP A OD2 1 ? 
ATOM   907  N N   . GLY A 1 116 ? -10.218 -4.893  16.150 1.00 60.22  ? 148 GLY A N   1 ? 
ATOM   908  C CA  . GLY A 1 116 ? -9.791  -5.962  17.036 1.00 56.94  ? 148 GLY A CA  1 ? 
ATOM   909  C C   . GLY A 1 116 ? -9.690  -5.532  18.502 1.00 53.64  ? 148 GLY A C   1 ? 
ATOM   910  O O   . GLY A 1 116 ? -9.525  -6.365  19.384 1.00 61.06  ? 148 GLY A O   1 ? 
ATOM   911  N N   . GLY A 1 117 ? -9.765  -4.235  18.786 1.00 55.96  ? 149 GLY A N   1 ? 
ATOM   912  C CA  . GLY A 1 117 ? -9.636  -3.758  20.154 1.00 55.62  ? 149 GLY A CA  1 ? 
ATOM   913  C C   . GLY A 1 117 ? -8.185  -3.794  20.639 1.00 57.57  ? 149 GLY A C   1 ? 
ATOM   914  O O   . GLY A 1 117 ? -7.264  -3.862  19.829 1.00 59.71  ? 149 GLY A O   1 ? 
ATOM   915  N N   . SER A 1 118 ? -8.015  -3.731  21.968 1.00 54.76  ? 150 SER A N   1 ? 
ATOM   916  C CA  . SER A 1 118 ? -6.722  -3.759  22.628 1.00 62.70  ? 150 SER A CA  1 ? 
ATOM   917  C C   . SER A 1 118 ? -6.300  -5.193  22.926 1.00 63.71  ? 150 SER A C   1 ? 
ATOM   918  O O   . SER A 1 118 ? -7.146  -6.077  23.080 1.00 62.20  ? 150 SER A O   1 ? 
ATOM   919  C CB  . SER A 1 118 ? -6.772  -2.981  23.893 1.00 65.58  ? 150 SER A CB  1 ? 
ATOM   920  O OG  . SER A 1 118 ? -7.802  -3.494  24.718 1.00 74.39  ? 150 SER A OG  1 ? 
ATOM   921  N N   . LEU A 1 119 ? -4.983  -5.402  23.038 1.00 58.22  ? 151 LEU A N   1 ? 
ATOM   922  C CA  . LEU A 1 119 ? -4.433  -6.741  23.213 1.00 64.40  ? 151 LEU A CA  1 ? 
ATOM   923  C C   . LEU A 1 119 ? -4.701  -7.324  24.609 1.00 60.41  ? 151 LEU A C   1 ? 
ATOM   924  O O   . LEU A 1 119 ? -4.612  -8.533  24.780 1.00 67.89  ? 151 LEU A O   1 ? 
ATOM   925  C CB  . LEU A 1 119 ? -2.948  -6.749  22.856 1.00 63.90  ? 151 LEU A CB  1 ? 
ATOM   926  C CG  . LEU A 1 119 ? -2.624  -6.759  21.359 1.00 67.43  ? 151 LEU A CG  1 ? 
ATOM   927  C CD1 . LEU A 1 119 ? -1.135  -6.999  21.196 1.00 67.05  ? 151 LEU A CD1 1 ? 
ATOM   928  C CD2 . LEU A 1 119 ? -3.425  -7.794  20.577 1.00 71.99  ? 151 LEU A CD2 1 ? 
ATOM   929  N N   A ASP A 1 120 ? -5.010  -6.478  25.597 0.50 58.07  ? 152 ASP A N   1 ? 
ATOM   930  N N   B ASP A 1 120 ? -5.032  -6.464  25.581 0.50 59.64  ? 152 ASP A N   1 ? 
ATOM   931  C CA  A ASP A 1 120 ? -5.484  -6.954  26.886 0.50 61.18  ? 152 ASP A CA  1 ? 
ATOM   932  C CA  B ASP A 1 120 ? -5.482  -6.898  26.893 0.50 63.69  ? 152 ASP A CA  1 ? 
ATOM   933  C C   A ASP A 1 120 ? -6.835  -7.642  26.699 0.50 58.03  ? 152 ASP A C   1 ? 
ATOM   934  C C   B ASP A 1 120 ? -6.836  -7.594  26.738 0.50 59.24  ? 152 ASP A C   1 ? 
ATOM   935  O O   A ASP A 1 120 ? -7.068  -8.707  27.260 0.50 57.33  ? 152 ASP A O   1 ? 
ATOM   936  O O   B ASP A 1 120 ? -7.068  -8.629  27.353 0.50 59.14  ? 152 ASP A O   1 ? 
ATOM   937  C CB  A ASP A 1 120 ? -5.594  -5.830  27.904 0.50 63.47  ? 152 ASP A CB  1 ? 
ATOM   938  C CB  B ASP A 1 120 ? -5.506  -5.732  27.876 0.50 67.83  ? 152 ASP A CB  1 ? 
ATOM   939  C CG  A ASP A 1 120 ? -6.622  -4.773  27.544 0.50 67.55  ? 152 ASP A CG  1 ? 
ATOM   940  C CG  B ASP A 1 120 ? -4.883  -5.974  29.248 0.50 75.42  ? 152 ASP A CG  1 ? 
ATOM   941  O OD1 A ASP A 1 120 ? -6.564  -4.299  26.393 0.50 67.25  ? 152 ASP A OD1 1 ? 
ATOM   942  O OD1 B ASP A 1 120 ? -4.330  -7.079  29.480 0.50 76.86  ? 152 ASP A OD1 1 ? 
ATOM   943  O OD2 A ASP A 1 120 ? -7.481  -4.460  28.398 0.50 74.00  ? 152 ASP A OD2 1 ? 
ATOM   944  O OD2 B ASP A 1 120 ? -4.926  -5.037  30.072 0.50 82.29  ? 152 ASP A OD2 1 ? 
ATOM   945  N N   . GLN A 1 121 ? -7.712  -7.045  25.884 1.00 54.98  ? 153 GLN A N   1 ? 
ATOM   946  C CA  . GLN A 1 121 ? -9.018  -7.635  25.626 1.00 55.80  ? 153 GLN A CA  1 ? 
ATOM   947  C C   . GLN A 1 121 ? -8.891  -8.875  24.740 1.00 56.41  ? 153 GLN A C   1 ? 
ATOM   948  O O   . GLN A 1 121 ? -9.615  -9.837  24.956 1.00 66.20  ? 153 GLN A O   1 ? 
ATOM   949  C CB  . GLN A 1 121 ? -10.030 -6.627  25.076 1.00 53.68  ? 153 GLN A CB  1 ? 
ATOM   950  C CG  . GLN A 1 121 ? -10.296 -5.450  26.013 1.00 67.94  ? 153 GLN A CG  1 ? 
ATOM   951  C CD  . GLN A 1 121 ? -10.721 -5.844  27.417 1.00 81.17  ? 153 GLN A CD  1 ? 
ATOM   952  O OE1 . GLN A 1 121 ? -10.019 -5.583  28.401 1.00 90.72  ? 153 GLN A OE1 1 ? 
ATOM   953  N NE2 . GLN A 1 121 ? -11.879 -6.482  27.533 1.00 81.45  ? 153 GLN A NE2 1 ? 
ATOM   954  N N   . VAL A 1 122 ? -7.969  -8.879  23.766 1.00 60.03  ? 154 VAL A N   1 ? 
ATOM   955  C CA  . VAL A 1 122 ? -7.733  -10.062 22.944 1.00 54.84  ? 154 VAL A CA  1 ? 
ATOM   956  C C   . VAL A 1 122 ? -7.184  -11.197 23.817 1.00 51.50  ? 154 VAL A C   1 ? 
ATOM   957  O O   . VAL A 1 122 ? -7.609  -12.338 23.697 1.00 53.38  ? 154 VAL A O   1 ? 
ATOM   958  C CB  . VAL A 1 122 ? -6.783  -9.750  21.768 1.00 54.70  ? 154 VAL A CB  1 ? 
ATOM   959  C CG1 . VAL A 1 122 ? -6.361  -11.003 20.999 1.00 53.96  ? 154 VAL A CG1 1 ? 
ATOM   960  C CG2 . VAL A 1 122 ? -7.387  -8.729  20.814 1.00 51.91  ? 154 VAL A CG2 1 ? 
ATOM   961  N N   . LEU A 1 123 ? -6.242  -10.875 24.704 1.00 48.94  ? 155 LEU A N   1 ? 
ATOM   962  C CA  . LEU A 1 123 ? -5.677  -11.818 25.652 1.00 49.51  ? 155 LEU A CA  1 ? 
ATOM   963  C C   . LEU A 1 123 ? -6.752  -12.589 26.408 1.00 55.47  ? 155 LEU A C   1 ? 
ATOM   964  O O   . LEU A 1 123 ? -6.605  -13.802 26.618 1.00 57.51  ? 155 LEU A O   1 ? 
ATOM   965  C CB  . LEU A 1 123 ? -4.784  -11.067 26.634 1.00 51.69  ? 155 LEU A CB  1 ? 
ATOM   966  C CG  . LEU A 1 123 ? -3.940  -11.947 27.558 1.00 55.68  ? 155 LEU A CG  1 ? 
ATOM   967  C CD1 . LEU A 1 123 ? -3.300  -13.075 26.752 1.00 57.49  ? 155 LEU A CD1 1 ? 
ATOM   968  C CD2 . LEU A 1 123 ? -2.872  -11.134 28.275 1.00 58.83  ? 155 LEU A CD2 1 ? 
ATOM   969  N N   . LYS A 1 124 ? -7.829  -11.888 26.798 1.00 62.30  ? 156 LYS A N   1 ? 
ATOM   970  C CA  . LYS A 1 124 ? -8.914  -12.486 27.566 1.00 60.56  ? 156 LYS A CA  1 ? 
ATOM   971  C C   . LYS A 1 124 ? -9.644  -13.513 26.709 1.00 63.71  ? 156 LYS A C   1 ? 
ATOM   972  O O   . LYS A 1 124 ? -9.983  -14.591 27.184 1.00 69.52  ? 156 LYS A O   1 ? 
ATOM   973  C CB  . LYS A 1 124 ? -9.851  -11.426 28.157 1.00 74.96  ? 156 LYS A CB  1 ? 
ATOM   974  C CG  . LYS A 1 124 ? -9.260  -10.668 29.344 1.00 84.69  ? 156 LYS A CG  1 ? 
ATOM   975  C CD  . LYS A 1 124 ? -9.965  -9.364  29.701 1.00 103.27 ? 156 LYS A CD  1 ? 
ATOM   976  C CE  . LYS A 1 124 ? -11.430 -9.545  29.969 1.00 117.60 ? 156 LYS A CE  1 ? 
ATOM   977  N NZ  . LYS A 1 124 ? -12.006 -8.399  30.678 1.00 119.79 ? 156 LYS A NZ  1 ? 
ATOM   978  N N   . LYS A 1 125 ? -9.840  -13.204 25.429 1.00 68.02  ? 157 LYS A N   1 ? 
ATOM   979  C CA  . LYS A 1 125 ? -10.444 -14.157 24.510 1.00 68.75  ? 157 LYS A CA  1 ? 
ATOM   980  C C   . LYS A 1 125 ? -9.457  -15.277 24.162 1.00 62.38  ? 157 LYS A C   1 ? 
ATOM   981  O O   . LYS A 1 125 ? -9.841  -16.431 23.979 1.00 62.88  ? 157 LYS A O   1 ? 
ATOM   982  C CB  . LYS A 1 125 ? -10.946 -13.415 23.261 1.00 79.44  ? 157 LYS A CB  1 ? 
ATOM   983  C CG  . LYS A 1 125 ? -12.448 -13.420 22.991 1.00 83.30  ? 157 LYS A CG  1 ? 
ATOM   984  C CD  . LYS A 1 125 ? -13.325 -12.695 23.999 1.00 83.13  ? 157 LYS A CD  1 ? 
ATOM   985  C CE  . LYS A 1 125 ? -14.780 -12.857 23.682 1.00 89.13  ? 157 LYS A CE  1 ? 
ATOM   986  N NZ  . LYS A 1 125 ? -15.152 -12.095 22.487 1.00 98.23  ? 157 LYS A NZ  1 ? 
ATOM   987  N N   . ALA A 1 126 ? -8.173  -14.946 24.031 1.00 56.40  ? 158 ALA A N   1 ? 
ATOM   988  C CA  . ALA A 1 126 ? -7.218  -15.933 23.559 1.00 52.63  ? 158 ALA A CA  1 ? 
ATOM   989  C C   . ALA A 1 126 ? -6.776  -16.868 24.689 1.00 54.70  ? 158 ALA A C   1 ? 
ATOM   990  O O   . ALA A 1 126 ? -6.620  -18.076 24.495 1.00 58.60  ? 158 ALA A O   1 ? 
ATOM   991  C CB  . ALA A 1 126 ? -6.046  -15.222 22.934 1.00 52.00  ? 158 ALA A CB  1 ? 
ATOM   992  N N   . GLY A 1 127 ? -6.549  -16.313 25.879 1.00 57.37  ? 159 GLY A N   1 ? 
ATOM   993  C CA  . GLY A 1 127 ? -5.838  -17.063 26.901 1.00 64.48  ? 159 GLY A CA  1 ? 
ATOM   994  C C   . GLY A 1 127 ? -4.342  -16.779 26.811 1.00 63.13  ? 159 GLY A C   1 ? 
ATOM   995  O O   . GLY A 1 127 ? -3.799  -16.143 27.714 1.00 64.50  ? 159 GLY A O   1 ? 
ATOM   996  N N   . ARG A 1 128 ? -3.721  -17.192 25.691 1.00 60.22  ? 160 ARG A N   1 ? 
ATOM   997  C CA  . ARG A 1 128 ? -2.341  -16.820 25.366 1.00 62.70  ? 160 ARG A CA  1 ? 
ATOM   998  C C   . ARG A 1 128 ? -2.225  -16.338 23.922 1.00 58.93  ? 160 ARG A C   1 ? 
ATOM   999  O O   . ARG A 1 128 ? -2.964  -16.797 23.060 1.00 64.52  ? 160 ARG A O   1 ? 
ATOM   1000 C CB  . ARG A 1 128 ? -1.376  -18.007 25.424 1.00 62.84  ? 160 ARG A CB  1 ? 
ATOM   1001 C CG  . ARG A 1 128 ? -1.220  -18.557 26.830 1.00 66.17  ? 160 ARG A CG  1 ? 
ATOM   1002 C CD  . ARG A 1 128 ? -0.049  -19.505 26.929 1.00 70.03  ? 160 ARG A CD  1 ? 
ATOM   1003 N NE  . ARG A 1 128 ? -0.375  -20.893 26.596 1.00 69.73  ? 160 ARG A NE  1 ? 
ATOM   1004 C CZ  . ARG A 1 128 ? -0.690  -21.793 27.515 1.00 71.24  ? 160 ARG A CZ  1 ? 
ATOM   1005 N NH1 . ARG A 1 128 ? -0.928  -21.415 28.765 1.00 79.53  ? 160 ARG A NH1 1 ? 
ATOM   1006 N NH2 . ARG A 1 128 ? -0.839  -23.054 27.162 1.00 67.50  ? 160 ARG A NH2 1 ? 
ATOM   1007 N N   . ILE A 1 129 ? -1.266  -15.448 23.651 1.00 59.43  ? 161 ILE A N   1 ? 
ATOM   1008 C CA  . ILE A 1 129 ? -1.035  -14.973 22.293 1.00 54.50  ? 161 ILE A CA  1 ? 
ATOM   1009 C C   . ILE A 1 129 ? 0.221   -15.647 21.749 1.00 57.35  ? 161 ILE A C   1 ? 
ATOM   1010 O O   . ILE A 1 129 ? 1.280   -15.620 22.364 1.00 62.85  ? 161 ILE A O   1 ? 
ATOM   1011 C CB  . ILE A 1 129 ? -0.986  -13.442 22.254 1.00 57.08  ? 161 ILE A CB  1 ? 
ATOM   1012 C CG1 . ILE A 1 129 ? -2.350  -12.891 22.690 1.00 57.90  ? 161 ILE A CG1 1 ? 
ATOM   1013 C CG2 . ILE A 1 129 ? -0.560  -12.921 20.875 1.00 60.02  ? 161 ILE A CG2 1 ? 
ATOM   1014 C CD1 . ILE A 1 129 ? -2.517  -11.388 22.564 1.00 58.47  ? 161 ILE A CD1 1 ? 
ATOM   1015 N N   . PRO A 1 130 ? 0.116   -16.365 20.615 1.00 54.36  ? 162 PRO A N   1 ? 
ATOM   1016 C CA  . PRO A 1 130 ? 1.224   -17.175 20.134 1.00 50.63  ? 162 PRO A CA  1 ? 
ATOM   1017 C C   . PRO A 1 130 ? 2.409   -16.375 19.603 1.00 53.82  ? 162 PRO A C   1 ? 
ATOM   1018 O O   . PRO A 1 130 ? 2.303   -15.199 19.263 1.00 58.95  ? 162 PRO A O   1 ? 
ATOM   1019 C CB  . PRO A 1 130 ? 0.575   -18.080 19.065 1.00 49.11  ? 162 PRO A CB  1 ? 
ATOM   1020 C CG  . PRO A 1 130 ? -0.670  -17.377 18.641 1.00 49.84  ? 162 PRO A CG  1 ? 
ATOM   1021 C CD  . PRO A 1 130 ? -1.085  -16.481 19.782 1.00 55.74  ? 162 PRO A CD  1 ? 
ATOM   1022 N N   . GLU A 1 131 ? 3.543   -17.071 19.512 1.00 56.50  ? 163 GLU A N   1 ? 
ATOM   1023 C CA  . GLU A 1 131 ? 4.844   -16.466 19.286 1.00 56.38  ? 163 GLU A CA  1 ? 
ATOM   1024 C C   . GLU A 1 131 ? 4.895   -15.714 17.959 1.00 48.65  ? 163 GLU A C   1 ? 
ATOM   1025 O O   . GLU A 1 131 ? 5.438   -14.621 17.905 1.00 50.97  ? 163 GLU A O   1 ? 
ATOM   1026 C CB  . GLU A 1 131 ? 5.944   -17.526 19.308 1.00 59.73  ? 163 GLU A CB  1 ? 
ATOM   1027 C CG  . GLU A 1 131 ? 7.322   -16.892 19.426 1.00 63.87  ? 163 GLU A CG  1 ? 
ATOM   1028 C CD  . GLU A 1 131 ? 8.466   -17.881 19.349 1.00 70.82  ? 163 GLU A CD  1 ? 
ATOM   1029 O OE1 . GLU A 1 131 ? 8.473   -18.899 20.092 1.00 64.14  ? 163 GLU A OE1 1 ? 
ATOM   1030 O OE2 . GLU A 1 131 ? 9.356   -17.591 18.513 1.00 71.84  ? 163 GLU A OE2 1 ? 
ATOM   1031 N N   . GLN A 1 132 ? 4.363   -16.295 16.884 1.00 47.89  ? 164 GLN A N   1 ? 
ATOM   1032 C CA  . GLN A 1 132 ? 4.437   -15.626 15.596 1.00 55.64  ? 164 GLN A CA  1 ? 
ATOM   1033 C C   . GLN A 1 132 ? 3.642   -14.321 15.623 1.00 58.68  ? 164 GLN A C   1 ? 
ATOM   1034 O O   . GLN A 1 132 ? 4.031   -13.357 14.979 1.00 68.75  ? 164 GLN A O   1 ? 
ATOM   1035 C CB  . GLN A 1 132 ? 3.961   -16.542 14.468 1.00 65.11  ? 164 GLN A CB  1 ? 
ATOM   1036 C CG  . GLN A 1 132 ? 4.963   -17.620 14.062 1.00 64.06  ? 164 GLN A CG  1 ? 
ATOM   1037 C CD  . GLN A 1 132 ? 4.603   -18.331 12.773 1.00 68.11  ? 164 GLN A CD  1 ? 
ATOM   1038 O OE1 . GLN A 1 132 ? 3.461   -18.306 12.295 1.00 70.29  ? 164 GLN A OE1 1 ? 
ATOM   1039 N NE2 . GLN A 1 132 ? 5.588   -18.992 12.190 1.00 77.40  ? 164 GLN A NE2 1 ? 
ATOM   1040 N N   . ILE A 1 133 ? 2.532   -14.277 16.369 1.00 61.46  ? 165 ILE A N   1 ? 
ATOM   1041 C CA  . ILE A 1 133 ? 1.739   -13.057 16.455 1.00 53.70  ? 165 ILE A CA  1 ? 
ATOM   1042 C C   . ILE A 1 133 ? 2.498   -11.998 17.239 1.00 50.40  ? 165 ILE A C   1 ? 
ATOM   1043 O O   . ILE A 1 133 ? 2.521   -10.841 16.844 1.00 61.42  ? 165 ILE A O   1 ? 
ATOM   1044 C CB  . ILE A 1 133 ? 0.361   -13.326 17.080 1.00 49.07  ? 165 ILE A CB  1 ? 
ATOM   1045 C CG1 . ILE A 1 133 ? -0.451  -14.269 16.220 1.00 49.98  ? 165 ILE A CG1 1 ? 
ATOM   1046 C CG2 . ILE A 1 133 ? -0.386  -12.021 17.332 1.00 46.38  ? 165 ILE A CG2 1 ? 
ATOM   1047 C CD1 . ILE A 1 133 ? -0.790  -13.694 14.859 1.00 54.56  ? 165 ILE A CD1 1 ? 
ATOM   1048 N N   . LEU A 1 134 ? 3.092   -12.396 18.362 1.00 51.06  ? 166 LEU A N   1 ? 
ATOM   1049 C CA  . LEU A 1 134 ? 3.902   -11.498 19.168 1.00 54.05  ? 166 LEU A CA  1 ? 
ATOM   1050 C C   . LEU A 1 134 ? 5.165   -11.026 18.437 1.00 57.56  ? 166 LEU A C   1 ? 
ATOM   1051 O O   . LEU A 1 134 ? 5.730   -9.983  18.772 1.00 56.54  ? 166 LEU A O   1 ? 
ATOM   1052 C CB  . LEU A 1 134 ? 4.223   -12.253 20.453 1.00 55.51  ? 166 LEU A CB  1 ? 
ATOM   1053 C CG  . LEU A 1 134 ? 3.015   -12.534 21.355 1.00 58.12  ? 166 LEU A CG  1 ? 
ATOM   1054 C CD1 . LEU A 1 134 ? 3.395   -13.246 22.654 1.00 62.57  ? 166 LEU A CD1 1 ? 
ATOM   1055 C CD2 . LEU A 1 134 ? 2.269   -11.242 21.677 1.00 57.30  ? 166 LEU A CD2 1 ? 
ATOM   1056 N N   . GLY A 1 135 ? 5.616   -11.770 17.427 1.00 59.37  ? 167 GLY A N   1 ? 
ATOM   1057 C CA  . GLY A 1 135 ? 6.688   -11.281 16.577 1.00 60.84  ? 167 GLY A CA  1 ? 
ATOM   1058 C C   . GLY A 1 135 ? 6.242   -10.020 15.843 1.00 59.79  ? 167 GLY A C   1 ? 
ATOM   1059 O O   . GLY A 1 135 ? 6.851   -8.962  15.966 1.00 62.16  ? 167 GLY A O   1 ? 
ATOM   1060 N N   . LYS A 1 136 ? 5.125   -10.146 15.128 1.00 59.90  ? 168 LYS A N   1 ? 
ATOM   1061 C CA  . LYS A 1 136 ? 4.513   -9.039  14.417 1.00 58.03  ? 168 LYS A CA  1 ? 
ATOM   1062 C C   . LYS A 1 136 ? 4.146   -7.894  15.358 1.00 60.45  ? 168 LYS A C   1 ? 
ATOM   1063 O O   . LYS A 1 136 ? 4.251   -6.730  14.978 1.00 58.76  ? 168 LYS A O   1 ? 
ATOM   1064 C CB  . LYS A 1 136 ? 3.269   -9.555  13.705 1.00 55.81  ? 168 LYS A CB  1 ? 
ATOM   1065 C CG  . LYS A 1 136 ? 3.562   -10.622 12.680 1.00 60.30  ? 168 LYS A CG  1 ? 
ATOM   1066 C CD  . LYS A 1 136 ? 4.570   -10.242 11.604 1.00 60.45  ? 168 LYS A CD  1 ? 
ATOM   1067 C CE  . LYS A 1 136 ? 4.866   -11.438 10.743 1.00 64.02  ? 168 LYS A CE  1 ? 
ATOM   1068 N NZ  . LYS A 1 136 ? 5.658   -11.104 9.559  1.00 72.90  ? 168 LYS A NZ  1 ? 
ATOM   1069 N N   . VAL A 1 137 ? 3.720   -8.217  16.584 1.00 59.99  ? 169 VAL A N   1 ? 
ATOM   1070 C CA  . VAL A 1 137 ? 3.396   -7.182  17.555 1.00 58.21  ? 169 VAL A CA  1 ? 
ATOM   1071 C C   . VAL A 1 137 ? 4.678   -6.431  17.902 1.00 58.85  ? 169 VAL A C   1 ? 
ATOM   1072 O O   . VAL A 1 137 ? 4.725   -5.205  17.853 1.00 55.10  ? 169 VAL A O   1 ? 
ATOM   1073 C CB  . VAL A 1 137 ? 2.728   -7.763  18.815 1.00 58.92  ? 169 VAL A CB  1 ? 
ATOM   1074 C CG1 . VAL A 1 137 ? 2.742   -6.779  19.975 1.00 58.44  ? 169 VAL A CG1 1 ? 
ATOM   1075 C CG2 . VAL A 1 137 ? 1.317   -8.261  18.539 1.00 61.73  ? 169 VAL A CG2 1 ? 
ATOM   1076 N N   . SER A 1 138 ? 5.711   -7.200  18.256 1.00 60.10  ? 170 SER A N   1 ? 
ATOM   1077 C CA  . SER A 1 138 ? 7.028   -6.671  18.576 1.00 60.69  ? 170 SER A CA  1 ? 
ATOM   1078 C C   . SER A 1 138 ? 7.515   -5.732  17.476 1.00 58.86  ? 170 SER A C   1 ? 
ATOM   1079 O O   . SER A 1 138 ? 8.029   -4.650  17.754 1.00 57.97  ? 170 SER A O   1 ? 
ATOM   1080 C CB  . SER A 1 138 ? 8.036   -7.797  18.804 1.00 64.57  ? 170 SER A CB  1 ? 
ATOM   1081 O OG  . SER A 1 138 ? 7.609   -8.738  19.788 1.00 61.96  ? 170 SER A OG  1 ? 
ATOM   1082 N N   . ILE A 1 139 ? 7.381   -6.146  16.217 1.00 60.00  ? 171 ILE A N   1 ? 
ATOM   1083 C CA  . ILE A 1 139 ? 7.862   -5.302  15.136 1.00 68.51  ? 171 ILE A CA  1 ? 
ATOM   1084 C C   . ILE A 1 139 ? 7.112   -3.967  15.151 1.00 69.00  ? 171 ILE A C   1 ? 
ATOM   1085 O O   . ILE A 1 139 ? 7.737   -2.908  15.091 1.00 74.31  ? 171 ILE A O   1 ? 
ATOM   1086 C CB  . ILE A 1 139 ? 7.783   -6.029  13.778 1.00 71.69  ? 171 ILE A CB  1 ? 
ATOM   1087 C CG1 . ILE A 1 139 ? 8.893   -7.082  13.665 1.00 68.27  ? 171 ILE A CG1 1 ? 
ATOM   1088 C CG2 . ILE A 1 139 ? 7.847   -5.037  12.614 1.00 74.07  ? 171 ILE A CG2 1 ? 
ATOM   1089 C CD1 . ILE A 1 139 ? 8.665   -8.113  12.579 1.00 68.09  ? 171 ILE A CD1 1 ? 
ATOM   1090 N N   . ALA A 1 140 ? 5.777   -4.020  15.237 1.00 67.03  ? 172 ALA A N   1 ? 
ATOM   1091 C CA  . ALA A 1 140 ? 4.949   -2.824  15.179 1.00 59.09  ? 172 ALA A CA  1 ? 
ATOM   1092 C C   . ALA A 1 140 ? 5.285   -1.878  16.326 1.00 58.30  ? 172 ALA A C   1 ? 
ATOM   1093 O O   . ALA A 1 140 ? 5.417   -0.682  16.128 1.00 61.42  ? 172 ALA A O   1 ? 
ATOM   1094 C CB  . ALA A 1 140 ? 3.497   -3.209  15.221 1.00 66.62  ? 172 ALA A CB  1 ? 
ATOM   1095 N N   . VAL A 1 141 ? 5.417   -2.417  17.533 1.00 59.55  ? 173 VAL A N   1 ? 
ATOM   1096 C CA  . VAL A 1 141 ? 5.747   -1.611  18.695 1.00 62.31  ? 173 VAL A CA  1 ? 
ATOM   1097 C C   . VAL A 1 141 ? 7.120   -0.962  18.515 1.00 66.78  ? 173 VAL A C   1 ? 
ATOM   1098 O O   . VAL A 1 141 ? 7.254   0.250   18.659 1.00 64.96  ? 173 VAL A O   1 ? 
ATOM   1099 C CB  . VAL A 1 141 ? 5.683   -2.496  19.954 1.00 66.38  ? 173 VAL A CB  1 ? 
ATOM   1100 C CG1 . VAL A 1 141 ? 6.292   -1.825  21.174 1.00 69.36  ? 173 VAL A CG1 1 ? 
ATOM   1101 C CG2 . VAL A 1 141 ? 4.259   -2.948  20.256 1.00 65.69  ? 173 VAL A CG2 1 ? 
ATOM   1102 N N   . ILE A 1 142 ? 8.146   -1.756  18.191 1.00 64.51  ? 174 ILE A N   1 ? 
ATOM   1103 C CA  . ILE A 1 142 ? 9.479   -1.196  18.024 1.00 62.90  ? 174 ILE A CA  1 ? 
ATOM   1104 C C   . ILE A 1 142 ? 9.430   -0.045  17.027 1.00 59.27  ? 174 ILE A C   1 ? 
ATOM   1105 O O   . ILE A 1 142 ? 9.967   1.014   17.312 1.00 64.48  ? 174 ILE A O   1 ? 
ATOM   1106 C CB  . ILE A 1 142 ? 10.509  -2.259  17.612 1.00 69.03  ? 174 ILE A CB  1 ? 
ATOM   1107 C CG1 . ILE A 1 142 ? 10.907  -3.129  18.802 1.00 74.85  ? 174 ILE A CG1 1 ? 
ATOM   1108 C CG2 . ILE A 1 142 ? 11.733  -1.607  16.973 1.00 73.98  ? 174 ILE A CG2 1 ? 
ATOM   1109 C CD1 . ILE A 1 142 ? 11.579  -4.432  18.400 1.00 78.13  ? 174 ILE A CD1 1 ? 
ATOM   1110 N N   . LYS A 1 143 ? 8.788   -0.237  15.870 1.00 59.34  ? 175 LYS A N   1 ? 
ATOM   1111 C CA  . LYS A 1 143 ? 8.744   0.817   14.866 1.00 66.03  ? 175 LYS A CA  1 ? 
ATOM   1112 C C   . LYS A 1 143 ? 7.984   2.039   15.387 1.00 71.16  ? 175 LYS A C   1 ? 
ATOM   1113 O O   . LYS A 1 143 ? 8.340   3.172   15.067 1.00 77.09  ? 175 LYS A O   1 ? 
ATOM   1114 C CB  . LYS A 1 143 ? 8.122   0.338   13.551 1.00 66.20  ? 175 LYS A CB  1 ? 
ATOM   1115 C CG  . LYS A 1 143 ? 8.993   -0.641  12.781 1.00 65.83  ? 175 LYS A CG  1 ? 
ATOM   1116 C CD  . LYS A 1 143 ? 8.320   -1.191  11.532 1.00 70.44  ? 175 LYS A CD  1 ? 
ATOM   1117 C CE  . LYS A 1 143 ? 9.295   -1.931  10.690 1.00 75.85  ? 175 LYS A CE  1 ? 
ATOM   1118 N NZ  . LYS A 1 143 ? 8.651   -2.585  9.553  1.00 79.96  ? 175 LYS A NZ  1 ? 
ATOM   1119 N N   . GLY A 1 144 ? 6.930   1.801   16.173 1.00 69.28  ? 176 GLY A N   1 ? 
ATOM   1120 C CA  . GLY A 1 144 ? 6.128   2.873   16.737 1.00 68.36  ? 176 GLY A CA  1 ? 
ATOM   1121 C C   . GLY A 1 144 ? 6.931   3.745   17.699 1.00 70.35  ? 176 GLY A C   1 ? 
ATOM   1122 O O   . GLY A 1 144 ? 6.792   4.963   17.686 1.00 73.45  ? 176 GLY A O   1 ? 
ATOM   1123 N N   . LEU A 1 145 ? 7.742   3.103   18.546 1.00 69.58  ? 177 LEU A N   1 ? 
ATOM   1124 C CA  . LEU A 1 145 ? 8.685   3.799   19.409 1.00 79.32  ? 177 LEU A CA  1 ? 
ATOM   1125 C C   . LEU A 1 145 ? 9.710   4.552   18.562 1.00 76.12  ? 177 LEU A C   1 ? 
ATOM   1126 O O   . LEU A 1 145 ? 9.999   5.708   18.831 1.00 83.96  ? 177 LEU A O   1 ? 
ATOM   1127 C CB  . LEU A 1 145 ? 9.393   2.825   20.353 1.00 82.46  ? 177 LEU A CB  1 ? 
ATOM   1128 C CG  . LEU A 1 145 ? 8.512   2.031   21.325 1.00 85.96  ? 177 LEU A CG  1 ? 
ATOM   1129 C CD1 . LEU A 1 145 ? 9.463   1.204   22.169 1.00 91.06  ? 177 LEU A CD1 1 ? 
ATOM   1130 C CD2 . LEU A 1 145 ? 7.572   2.848   22.210 1.00 78.23  ? 177 LEU A CD2 1 ? 
ATOM   1131 N N   . THR A 1 146 ? 10.284  3.885   17.556 1.00 80.78  ? 178 THR A N   1 ? 
ATOM   1132 C CA  . THR A 1 146 ? 11.270  4.516   16.696 1.00 73.96  ? 178 THR A CA  1 ? 
ATOM   1133 C C   . THR A 1 146 ? 10.692  5.820   16.152 1.00 73.94  ? 178 THR A C   1 ? 
ATOM   1134 O O   . THR A 1 146 ? 11.339  6.853   16.229 1.00 73.53  ? 178 THR A O   1 ? 
ATOM   1135 C CB  . THR A 1 146 ? 11.689  3.558   15.582 1.00 77.91  ? 178 THR A CB  1 ? 
ATOM   1136 O OG1 . THR A 1 146 ? 12.521  2.583   16.203 1.00 86.23  ? 178 THR A OG1 1 ? 
ATOM   1137 C CG2 . THR A 1 146 ? 12.512  4.225   14.496 1.00 79.71  ? 178 THR A CG2 1 ? 
ATOM   1138 N N   . TYR A 1 147 ? 9.472   5.770   15.615 1.00 76.10  ? 179 TYR A N   1 ? 
ATOM   1139 C CA  . TYR A 1 147 ? 8.817   6.971   15.125 1.00 76.46  ? 179 TYR A CA  1 ? 
ATOM   1140 C C   . TYR A 1 147 ? 8.759   8.013   16.236 1.00 78.94  ? 179 TYR A C   1 ? 
ATOM   1141 O O   . TYR A 1 147 ? 9.208   9.138   16.050 1.00 93.96  ? 179 TYR A O   1 ? 
ATOM   1142 C CB  . TYR A 1 147 ? 7.413   6.643   14.618 1.00 76.27  ? 179 TYR A CB  1 ? 
ATOM   1143 C CG  . TYR A 1 147 ? 6.585   7.840   14.173 1.00 84.04  ? 179 TYR A CG  1 ? 
ATOM   1144 C CD1 . TYR A 1 147 ? 5.811   8.564   15.076 1.00 83.93  ? 179 TYR A CD1 1 ? 
ATOM   1145 C CD2 . TYR A 1 147 ? 6.549   8.221   12.837 1.00 86.56  ? 179 TYR A CD2 1 ? 
ATOM   1146 C CE1 . TYR A 1 147 ? 5.043   9.641   14.662 1.00 88.21  ? 179 TYR A CE1 1 ? 
ATOM   1147 C CE2 . TYR A 1 147 ? 5.775   9.288   12.409 1.00 84.64  ? 179 TYR A CE2 1 ? 
ATOM   1148 C CZ  . TYR A 1 147 ? 5.021   10.001  13.323 1.00 91.53  ? 179 TYR A CZ  1 ? 
ATOM   1149 O OH  . TYR A 1 147 ? 4.274   11.056  12.880 1.00 104.41 ? 179 TYR A OH  1 ? 
ATOM   1150 N N   . LEU A 1 148 ? 8.212   7.634   17.395 1.00 77.18  ? 180 LEU A N   1 ? 
ATOM   1151 C CA  . LEU A 1 148 ? 7.971   8.597   18.457 1.00 76.53  ? 180 LEU A CA  1 ? 
ATOM   1152 C C   . LEU A 1 148 ? 9.297   9.228   18.887 1.00 81.72  ? 180 LEU A C   1 ? 
ATOM   1153 O O   . LEU A 1 148 ? 9.342   10.429  19.142 1.00 84.39  ? 180 LEU A O   1 ? 
ATOM   1154 C CB  . LEU A 1 148 ? 7.217   7.968   19.631 1.00 77.19  ? 180 LEU A CB  1 ? 
ATOM   1155 C CG  . LEU A 1 148 ? 5.759   7.563   19.366 1.00 78.90  ? 180 LEU A CG  1 ? 
ATOM   1156 C CD1 . LEU A 1 148 ? 5.147   6.819   20.547 1.00 74.65  ? 180 LEU A CD1 1 ? 
ATOM   1157 C CD2 . LEU A 1 148 ? 4.893   8.761   19.003 1.00 75.75  ? 180 LEU A CD2 1 ? 
ATOM   1158 N N   . ARG A 1 149 ? 10.375  8.429   18.918 1.00 85.14  ? 181 ARG A N   1 ? 
ATOM   1159 C CA  . ARG A 1 149 ? 11.671  8.888   19.402 1.00 92.59  ? 181 ARG A CA  1 ? 
ATOM   1160 C C   . ARG A 1 149 ? 12.303  9.813   18.364 1.00 89.36  ? 181 ARG A C   1 ? 
ATOM   1161 O O   . ARG A 1 149 ? 13.021  10.740  18.732 1.00 83.33  ? 181 ARG A O   1 ? 
ATOM   1162 C CB  . ARG A 1 149 ? 12.677  7.765   19.710 1.00 103.52 ? 181 ARG A CB  1 ? 
ATOM   1163 C CG  . ARG A 1 149 ? 13.740  8.135   20.742 1.00 115.47 ? 181 ARG A CG  1 ? 
ATOM   1164 C CD  . ARG A 1 149 ? 15.202  7.836   20.366 1.00 130.10 ? 181 ARG A CD  1 ? 
ATOM   1165 N NE  . ARG A 1 149 ? 15.586  6.442   20.102 1.00 148.74 ? 181 ARG A NE  1 ? 
ATOM   1166 C CZ  . ARG A 1 149 ? 15.972  5.923   18.928 1.00 160.88 ? 181 ARG A CZ  1 ? 
ATOM   1167 N NH1 . ARG A 1 149 ? 16.561  4.737   18.893 1.00 157.66 ? 181 ARG A NH1 1 ? 
ATOM   1168 N NH2 . ARG A 1 149 ? 15.828  6.595   17.795 1.00 164.57 ? 181 ARG A NH2 1 ? 
ATOM   1169 N N   . GLU A 1 150 ? 12.015  9.558   17.079 1.00 90.08  ? 182 GLU A N   1 ? 
ATOM   1170 C CA  . GLU A 1 150 ? 12.606  10.309  15.981 1.00 107.81 ? 182 GLU A CA  1 ? 
ATOM   1171 C C   . GLU A 1 150 ? 11.579  11.295  15.430 1.00 117.54 ? 182 GLU A C   1 ? 
ATOM   1172 O O   . GLU A 1 150 ? 11.485  11.460  14.215 1.00 125.51 ? 182 GLU A O   1 ? 
ATOM   1173 C CB  . GLU A 1 150 ? 13.100  9.418   14.834 1.00 111.80 ? 182 GLU A CB  1 ? 
ATOM   1174 C CG  . GLU A 1 150 ? 14.297  8.534   15.184 1.00 123.24 ? 182 GLU A CG  1 ? 
ATOM   1175 C CD  . GLU A 1 150 ? 15.559  9.252   15.648 1.00 128.93 ? 182 GLU A CD  1 ? 
ATOM   1176 O OE1 . GLU A 1 150 ? 15.949  9.024   16.812 1.00 138.45 ? 182 GLU A OE1 1 ? 
ATOM   1177 O OE2 . GLU A 1 150 ? 16.163  10.027  14.871 1.00 118.89 ? 182 GLU A OE2 1 ? 
ATOM   1178 N N   . LYS A 1 151 ? 10.813  11.941  16.323 1.00 119.18 ? 183 LYS A N   1 ? 
ATOM   1179 C CA  . LYS A 1 151 ? 9.834   12.930  15.899 1.00 114.67 ? 183 LYS A CA  1 ? 
ATOM   1180 C C   . LYS A 1 151 ? 9.248   13.633  17.114 1.00 109.76 ? 183 LYS A C   1 ? 
ATOM   1181 O O   . LYS A 1 151 ? 9.617   14.765  17.409 1.00 112.19 ? 183 LYS A O   1 ? 
ATOM   1182 C CB  . LYS A 1 151 ? 8.697   12.343  15.052 1.00 113.76 ? 183 LYS A CB  1 ? 
ATOM   1183 C CG  . LYS A 1 151 ? 7.861   13.388  14.328 1.00 120.76 ? 183 LYS A CG  1 ? 
ATOM   1184 C CD  . LYS A 1 151 ? 7.198   12.909  13.042 1.00 126.91 ? 183 LYS A CD  1 ? 
ATOM   1185 C CE  . LYS A 1 151 ? 8.119   12.231  12.061 1.00 134.48 ? 183 LYS A CE  1 ? 
ATOM   1186 N NZ  . LYS A 1 151 ? 9.279   13.033  11.659 1.00 136.67 ? 183 LYS A NZ  1 ? 
ATOM   1187 N N   . HIS A 1 152 ? 8.338   12.950  17.812 1.00 121.95 ? 184 HIS A N   1 ? 
ATOM   1188 C CA  . HIS A 1 152 ? 7.501   13.610  18.800 1.00 137.15 ? 184 HIS A CA  1 ? 
ATOM   1189 C C   . HIS A 1 152 ? 8.328   13.958  20.037 1.00 145.37 ? 184 HIS A C   1 ? 
ATOM   1190 O O   . HIS A 1 152 ? 7.967   14.865  20.781 1.00 149.67 ? 184 HIS A O   1 ? 
ATOM   1191 C CB  . HIS A 1 152 ? 6.274   12.758  19.154 1.00 131.72 ? 184 HIS A CB  1 ? 
ATOM   1192 C CG  . HIS A 1 152 ? 5.009   13.550  19.299 1.00 132.25 ? 184 HIS A CG  1 ? 
ATOM   1193 N ND1 . HIS A 1 152 ? 4.072   13.612  18.287 1.00 124.81 ? 184 HIS A ND1 1 ? 
ATOM   1194 C CD2 . HIS A 1 152 ? 4.518   14.301  20.297 1.00 130.99 ? 184 HIS A CD2 1 ? 
ATOM   1195 C CE1 . HIS A 1 152 ? 3.058   14.373  18.672 1.00 127.88 ? 184 HIS A CE1 1 ? 
ATOM   1196 N NE2 . HIS A 1 152 ? 3.308   14.802  19.890 1.00 129.15 ? 184 HIS A NE2 1 ? 
ATOM   1197 N N   . LYS A 1 153 ? 9.436   13.236  20.248 1.00 156.53 ? 185 LYS A N   1 ? 
ATOM   1198 C CA  . LYS A 1 153 ? 10.192  13.346  21.484 1.00 165.18 ? 185 LYS A CA  1 ? 
ATOM   1199 C C   . LYS A 1 153 ? 9.214   13.227  22.655 1.00 174.15 ? 185 LYS A C   1 ? 
ATOM   1200 O O   . LYS A 1 153 ? 9.409   13.856  23.694 1.00 178.79 ? 185 LYS A O   1 ? 
ATOM   1201 C CB  . LYS A 1 153 ? 10.979  14.665  21.545 1.00 163.78 ? 185 LYS A CB  1 ? 
ATOM   1202 C CG  . LYS A 1 153 ? 11.653  15.127  20.256 1.00 163.82 ? 185 LYS A CG  1 ? 
ATOM   1203 C CD  . LYS A 1 153 ? 12.922  14.384  19.855 1.00 164.71 ? 185 LYS A CD  1 ? 
ATOM   1204 C CE  . LYS A 1 153 ? 13.231  14.520  18.393 1.00 158.99 ? 185 LYS A CE  1 ? 
ATOM   1205 N NZ  . LYS A 1 153 ? 13.130  15.899  17.910 1.00 146.86 ? 185 LYS A NZ  1 ? 
ATOM   1206 N N   . ILE A 1 154 ? 8.159   12.416  22.470 1.00 173.42 ? 186 ILE A N   1 ? 
ATOM   1207 C CA  . ILE A 1 154 ? 7.059   12.329  23.421 1.00 176.58 ? 186 ILE A CA  1 ? 
ATOM   1208 C C   . ILE A 1 154 ? 7.410   11.295  24.488 1.00 173.32 ? 186 ILE A C   1 ? 
ATOM   1209 O O   . ILE A 1 154 ? 7.982   10.251  24.178 1.00 164.63 ? 186 ILE A O   1 ? 
ATOM   1210 C CB  . ILE A 1 154 ? 5.732   11.980  22.717 1.00 179.24 ? 186 ILE A CB  1 ? 
ATOM   1211 C CG1 . ILE A 1 154 ? 4.518   12.312  23.601 1.00 181.94 ? 186 ILE A CG1 1 ? 
ATOM   1212 C CG2 . ILE A 1 154 ? 5.719   10.528  22.234 1.00 181.84 ? 186 ILE A CG2 1 ? 
ATOM   1213 C CD1 . ILE A 1 154 ? 3.236   11.588  23.224 1.00 185.31 ? 186 ILE A CD1 1 ? 
ATOM   1214 N N   . MET A 1 155 ? 7.026   11.578  25.741 1.00 173.97 ? 187 MET A N   1 ? 
ATOM   1215 C CA  . MET A 1 155 ? 7.303   10.671  26.844 1.00 174.64 ? 187 MET A CA  1 ? 
ATOM   1216 C C   . MET A 1 155 ? 6.528   9.366   26.663 1.00 178.49 ? 187 MET A C   1 ? 
ATOM   1217 O O   . MET A 1 155 ? 6.886   8.354   27.265 1.00 182.64 ? 187 MET A O   1 ? 
ATOM   1218 C CB  . MET A 1 155 ? 6.910   11.261  28.205 1.00 164.67 ? 187 MET A CB  1 ? 
ATOM   1219 C CG  . MET A 1 155 ? 7.739   10.710  29.363 1.00 165.74 ? 187 MET A CG  1 ? 
ATOM   1220 S SD  . MET A 1 155 ? 6.820   10.279  30.856 1.00 154.93 ? 187 MET A SD  1 ? 
ATOM   1221 C CE  . MET A 1 155 ? 6.646   8.494   30.728 1.00 149.61 ? 187 MET A CE  1 ? 
ATOM   1222 N N   . HIS A 1 156 ? 5.456   9.405   25.857 1.00 171.57 ? 188 HIS A N   1 ? 
ATOM   1223 C CA  . HIS A 1 156 ? 4.596   8.251   25.657 1.00 161.49 ? 188 HIS A CA  1 ? 
ATOM   1224 C C   . HIS A 1 156 ? 3.821   8.030   26.958 1.00 155.26 ? 188 HIS A C   1 ? 
ATOM   1225 O O   . HIS A 1 156 ? 2.877   8.766   27.240 1.00 142.43 ? 188 HIS A O   1 ? 
ATOM   1226 C CB  . HIS A 1 156 ? 5.435   7.100   25.080 1.00 156.38 ? 188 HIS A CB  1 ? 
ATOM   1227 C CG  . HIS A 1 156 ? 4.659   5.898   24.679 1.00 143.18 ? 188 HIS A CG  1 ? 
ATOM   1228 N ND1 . HIS A 1 156 ? 3.901   5.861   23.532 1.00 143.26 ? 188 HIS A ND1 1 ? 
ATOM   1229 C CD2 . HIS A 1 156 ? 4.515   4.705   25.260 1.00 149.21 ? 188 HIS A CD2 1 ? 
ATOM   1230 C CE1 . HIS A 1 156 ? 3.321   4.675   23.435 1.00 152.47 ? 188 HIS A CE1 1 ? 
ATOM   1231 N NE2 . HIS A 1 156 ? 3.678   3.956   24.475 1.00 155.01 ? 188 HIS A NE2 1 ? 
ATOM   1232 N N   . ARG A 1 157 ? 4.239   7.033   27.748 1.00 158.03 ? 189 ARG A N   1 ? 
ATOM   1233 C CA  . ARG A 1 157 ? 3.731   6.794   29.094 1.00 159.95 ? 189 ARG A CA  1 ? 
ATOM   1234 C C   . ARG A 1 157 ? 4.065   5.346   29.462 1.00 155.91 ? 189 ARG A C   1 ? 
ATOM   1235 O O   . ARG A 1 157 ? 4.907   5.110   30.328 1.00 166.79 ? 189 ARG A O   1 ? 
ATOM   1236 C CB  . ARG A 1 157 ? 2.239   7.115   29.290 1.00 159.16 ? 189 ARG A CB  1 ? 
ATOM   1237 C CG  . ARG A 1 157 ? 1.782   7.151   30.742 1.00 161.65 ? 189 ARG A CG  1 ? 
ATOM   1238 C CD  . ARG A 1 157 ? 0.282   6.940   30.902 1.00 158.57 ? 189 ARG A CD  1 ? 
ATOM   1239 N NE  . ARG A 1 157 ? -0.073  5.547   30.609 1.00 160.27 ? 189 ARG A NE  1 ? 
ATOM   1240 C CZ  . ARG A 1 157 ? -0.870  5.116   29.635 1.00 173.77 ? 189 ARG A CZ  1 ? 
ATOM   1241 N NH1 . ARG A 1 157 ? -1.600  5.955   28.918 1.00 177.37 ? 189 ARG A NH1 1 ? 
ATOM   1242 N NH2 . ARG A 1 157 ? -0.954  3.820   29.396 1.00 178.25 ? 189 ARG A NH2 1 ? 
ATOM   1243 N N   . ASP A 1 158 ? 3.420   4.389   28.777 1.00 130.93 ? 190 ASP A N   1 ? 
ATOM   1244 C CA  . ASP A 1 158 ? 3.737   2.974   28.914 1.00 124.74 ? 190 ASP A CA  1 ? 
ATOM   1245 C C   . ASP A 1 158 ? 3.427   2.220   27.621 1.00 113.54 ? 190 ASP A C   1 ? 
ATOM   1246 O O   . ASP A 1 158 ? 2.645   2.653   26.773 1.00 106.40 ? 190 ASP A O   1 ? 
ATOM   1247 C CB  . ASP A 1 158 ? 3.000   2.330   30.080 1.00 127.06 ? 190 ASP A CB  1 ? 
ATOM   1248 C CG  . ASP A 1 158 ? 3.746   2.268   31.406 1.00 139.79 ? 190 ASP A CG  1 ? 
ATOM   1249 O OD1 . ASP A 1 158 ? 4.993   2.404   31.390 1.00 149.11 ? 190 ASP A OD1 1 ? 
ATOM   1250 O OD2 . ASP A 1 158 ? 3.069   2.082   32.450 1.00 129.42 ? 190 ASP A OD2 1 ? 
ATOM   1251 N N   . VAL A 1 159 ? 4.087   1.072   27.484 1.00 98.95  ? 191 VAL A N   1 ? 
ATOM   1252 C CA  . VAL A 1 159 ? 3.693   0.065   26.521 1.00 86.71  ? 191 VAL A CA  1 ? 
ATOM   1253 C C   . VAL A 1 159 ? 3.190   -1.116  27.346 1.00 81.72  ? 191 VAL A C   1 ? 
ATOM   1254 O O   . VAL A 1 159 ? 3.953   -1.769  28.055 1.00 76.28  ? 191 VAL A O   1 ? 
ATOM   1255 C CB  . VAL A 1 159 ? 4.819   -0.340  25.549 1.00 87.80  ? 191 VAL A CB  1 ? 
ATOM   1256 C CG1 . VAL A 1 159 ? 4.325   -1.296  24.473 1.00 87.80  ? 191 VAL A CG1 1 ? 
ATOM   1257 C CG2 . VAL A 1 159 ? 5.461   0.871   24.890 1.00 87.47  ? 191 VAL A CG2 1 ? 
ATOM   1258 N N   . LYS A 1 160 ? 1.872   -1.300  27.287 1.00 79.21  ? 192 LYS A N   1 ? 
ATOM   1259 C CA  . LYS A 1 160 ? 1.151   -2.379  27.928 1.00 71.57  ? 192 LYS A CA  1 ? 
ATOM   1260 C C   . LYS A 1 160 ? 0.268   -2.991  26.854 1.00 65.56  ? 192 LYS A C   1 ? 
ATOM   1261 O O   . LYS A 1 160 ? 0.061   -2.360  25.816 1.00 68.97  ? 192 LYS A O   1 ? 
ATOM   1262 C CB  . LYS A 1 160 ? 0.200   -1.831  28.994 1.00 78.25  ? 192 LYS A CB  1 ? 
ATOM   1263 C CG  . LYS A 1 160 ? 0.852   -0.970  30.044 1.00 87.13  ? 192 LYS A CG  1 ? 
ATOM   1264 C CD  . LYS A 1 160 ? -0.058  -0.495  31.171 1.00 94.75  ? 192 LYS A CD  1 ? 
ATOM   1265 C CE  . LYS A 1 160 ? -0.669  0.846   30.939 1.00 101.00 ? 192 LYS A CE  1 ? 
ATOM   1266 N NZ  . LYS A 1 160 ? -1.829  0.758   30.052 1.00 109.42 ? 192 LYS A NZ  1 ? 
ATOM   1267 N N   . PRO A 1 161 ? -0.324  -4.183  27.079 1.00 62.41  ? 193 PRO A N   1 ? 
ATOM   1268 C CA  . PRO A 1 161 ? -1.362  -4.704  26.180 1.00 64.29  ? 193 PRO A CA  1 ? 
ATOM   1269 C C   . PRO A 1 161 ? -2.538  -3.762  25.931 1.00 61.51  ? 193 PRO A C   1 ? 
ATOM   1270 O O   . PRO A 1 161 ? -3.055  -3.692  24.819 1.00 64.56  ? 193 PRO A O   1 ? 
ATOM   1271 C CB  . PRO A 1 161 ? -1.789  -5.982  26.883 1.00 61.02  ? 193 PRO A CB  1 ? 
ATOM   1272 C CG  . PRO A 1 161 ? -0.524  -6.419  27.567 1.00 64.67  ? 193 PRO A CG  1 ? 
ATOM   1273 C CD  . PRO A 1 161 ? 0.031   -5.129  28.146 1.00 64.08  ? 193 PRO A CD  1 ? 
ATOM   1274 N N   . SER A 1 162 ? -2.931  -3.005  26.955 1.00 65.18  ? 194 SER A N   1 ? 
ATOM   1275 C CA  . SER A 1 162 ? -4.049  -2.087  26.819 1.00 67.07  ? 194 SER A CA  1 ? 
ATOM   1276 C C   . SER A 1 162 ? -3.729  -0.975  25.820 1.00 62.41  ? 194 SER A C   1 ? 
ATOM   1277 O O   . SER A 1 162 ? -4.640  -0.400  25.231 1.00 65.04  ? 194 SER A O   1 ? 
ATOM   1278 C CB  . SER A 1 162 ? -4.480  -1.536  28.159 1.00 67.64  ? 194 SER A CB  1 ? 
ATOM   1279 O OG  . SER A 1 162 ? -3.370  -1.089  28.924 1.00 72.52  ? 194 SER A OG  1 ? 
ATOM   1280 N N   . ASN A 1 163 ? -2.443  -0.687  25.596 1.00 65.71  ? 195 ASN A N   1 ? 
ATOM   1281 C CA  . ASN A 1 163 ? -2.051  0.351   24.653 1.00 60.89  ? 195 ASN A CA  1 ? 
ATOM   1282 C C   . ASN A 1 163 ? -1.848  -0.153  23.219 1.00 58.56  ? 195 ASN A C   1 ? 
ATOM   1283 O O   . ASN A 1 163 ? -1.522  0.648   22.347 1.00 53.45  ? 195 ASN A O   1 ? 
ATOM   1284 C CB  . ASN A 1 163 ? -0.716  0.967   25.031 1.00 66.42  ? 195 ASN A CB  1 ? 
ATOM   1285 C CG  . ASN A 1 163 ? -0.772  1.623   26.378 1.00 72.01  ? 195 ASN A CG  1 ? 
ATOM   1286 O OD1 . ASN A 1 163 ? -1.724  2.353   26.668 1.00 90.70  ? 195 ASN A OD1 1 ? 
ATOM   1287 N ND2 . ASN A 1 163 ? 0.242   1.396   27.194 1.00 88.07  ? 195 ASN A ND2 1 ? 
ATOM   1288 N N   . ILE A 1 164 ? -1.980  -1.463  22.974 1.00 52.96  ? 196 ILE A N   1 ? 
ATOM   1289 C CA  . ILE A 1 164 ? -1.698  -2.023  21.665 1.00 54.71  ? 196 ILE A CA  1 ? 
ATOM   1290 C C   . ILE A 1 164 ? -3.023  -2.446  21.051 1.00 53.35  ? 196 ILE A C   1 ? 
ATOM   1291 O O   . ILE A 1 164 ? -3.652  -3.377  21.546 1.00 58.08  ? 196 ILE A O   1 ? 
ATOM   1292 C CB  . ILE A 1 164 ? -0.686  -3.180  21.766 1.00 57.04  ? 196 ILE A CB  1 ? 
ATOM   1293 C CG1 . ILE A 1 164 ? 0.624   -2.711  22.389 1.00 62.29  ? 196 ILE A CG1 1 ? 
ATOM   1294 C CG2 . ILE A 1 164 ? -0.445  -3.827  20.403 1.00 60.06  ? 196 ILE A CG2 1 ? 
ATOM   1295 C CD1 . ILE A 1 164 ? 1.669   -3.805  22.516 1.00 62.34  ? 196 ILE A CD1 1 ? 
ATOM   1296 N N   . LEU A 1 165 ? -3.447  -1.719  20.010 1.00 51.53  ? 197 LEU A N   1 ? 
ATOM   1297 C CA  . LEU A 1 165 ? -4.703  -1.991  19.349 1.00 50.91  ? 197 LEU A CA  1 ? 
ATOM   1298 C C   . LEU A 1 165 ? -4.403  -2.694  18.040 1.00 60.35  ? 197 LEU A C   1 ? 
ATOM   1299 O O   . LEU A 1 165 ? -3.352  -2.455  17.448 1.00 52.35  ? 197 LEU A O   1 ? 
ATOM   1300 C CB  . LEU A 1 165 ? -5.480  -0.710  19.084 1.00 53.83  ? 197 LEU A CB  1 ? 
ATOM   1301 C CG  . LEU A 1 165 ? -5.781  0.165   20.300 1.00 61.93  ? 197 LEU A CG  1 ? 
ATOM   1302 C CD1 . LEU A 1 165 ? -6.821  1.204   19.907 1.00 62.14  ? 197 LEU A CD1 1 ? 
ATOM   1303 C CD2 . LEU A 1 165 ? -6.244  -0.627  21.505 1.00 63.40  ? 197 LEU A CD2 1 ? 
ATOM   1304 N N   . VAL A 1 166 ? -5.369  -3.513  17.602 1.00 63.39  ? 198 VAL A N   1 ? 
ATOM   1305 C CA  . VAL A 1 166 ? -5.225  -4.359  16.430 1.00 60.56  ? 198 VAL A CA  1 ? 
ATOM   1306 C C   . VAL A 1 166 ? -6.511  -4.302  15.612 1.00 61.35  ? 198 VAL A C   1 ? 
ATOM   1307 O O   . VAL A 1 166 ? -7.557  -3.848  16.078 1.00 64.48  ? 198 VAL A O   1 ? 
ATOM   1308 C CB  . VAL A 1 166 ? -4.878  -5.820  16.777 1.00 65.03  ? 198 VAL A CB  1 ? 
ATOM   1309 C CG1 . VAL A 1 166 ? -3.575  -5.911  17.550 1.00 61.65  ? 198 VAL A CG1 1 ? 
ATOM   1310 C CG2 . VAL A 1 166 ? -6.004  -6.532  17.527 1.00 68.55  ? 198 VAL A CG2 1 ? 
ATOM   1311 N N   . ASN A 1 167 ? -6.432  -4.802  14.380 1.00 58.90  ? 199 ASN A N   1 ? 
ATOM   1312 C CA  . ASN A 1 167 ? -7.594  -4.768  13.517 1.00 59.86  ? 199 ASN A CA  1 ? 
ATOM   1313 C C   . ASN A 1 167 ? -7.485  -5.888  12.493 1.00 59.86  ? 199 ASN A C   1 ? 
ATOM   1314 O O   . ASN A 1 167 ? -6.430  -6.507  12.359 1.00 58.48  ? 199 ASN A O   1 ? 
ATOM   1315 C CB  . ASN A 1 167 ? -7.752  -3.383  12.908 1.00 63.65  ? 199 ASN A CB  1 ? 
ATOM   1316 C CG  . ASN A 1 167 ? -6.822  -3.146  11.745 1.00 62.82  ? 199 ASN A CG  1 ? 
ATOM   1317 O OD1 . ASN A 1 167 ? -6.207  -4.082  11.226 1.00 71.75  ? 199 ASN A OD1 1 ? 
ATOM   1318 N ND2 . ASN A 1 167 ? -6.715  -1.898  11.321 1.00 66.33  ? 199 ASN A ND2 1 ? 
ATOM   1319 N N   . SER A 1 168 ? -8.580  -6.067  11.748 1.00 60.61  ? 200 SER A N   1 ? 
ATOM   1320 C CA  . SER A 1 168 ? -8.797  -7.193  10.856 1.00 68.02  ? 200 SER A CA  1 ? 
ATOM   1321 C C   . SER A 1 168 ? -8.064  -7.027  9.527  1.00 68.20  ? 200 SER A C   1 ? 
ATOM   1322 O O   . SER A 1 168 ? -8.191  -7.885  8.655  1.00 69.25  ? 200 SER A O   1 ? 
ATOM   1323 C CB  . SER A 1 168 ? -10.269 -7.348  10.610 1.00 76.39  ? 200 SER A CB  1 ? 
ATOM   1324 O OG  . SER A 1 168 ? -10.787 -6.173  10.000 1.00 67.58  ? 200 SER A OG  1 ? 
ATOM   1325 N N   . ARG A 1 169 ? -7.346  -5.907  9.372  1.00 75.75  ? 201 ARG A N   1 ? 
ATOM   1326 C CA  . ARG A 1 169 ? -6.419  -5.685  8.270  1.00 80.33  ? 201 ARG A CA  1 ? 
ATOM   1327 C C   . ARG A 1 169 ? -4.995  -6.077  8.678  1.00 70.76  ? 201 ARG A C   1 ? 
ATOM   1328 O O   . ARG A 1 169 ? -4.070  -6.034  7.868  1.00 69.04  ? 201 ARG A O   1 ? 
ATOM   1329 C CB  . ARG A 1 169 ? -6.507  -4.220  7.824  1.00 91.41  ? 201 ARG A CB  1 ? 
ATOM   1330 C CG  . ARG A 1 169 ? -7.450  -3.967  6.653  1.00 108.21 ? 201 ARG A CG  1 ? 
ATOM   1331 C CD  . ARG A 1 169 ? -8.085  -2.569  6.626  1.00 123.64 ? 201 ARG A CD  1 ? 
ATOM   1332 N NE  . ARG A 1 169 ? -7.252  -1.472  7.141  1.00 130.58 ? 201 ARG A NE  1 ? 
ATOM   1333 C CZ  . ARG A 1 169 ? -6.895  -0.346  6.515  1.00 128.68 ? 201 ARG A CZ  1 ? 
ATOM   1334 N NH1 . ARG A 1 169 ? -6.216  0.571   7.190  1.00 120.74 ? 201 ARG A NH1 1 ? 
ATOM   1335 N NH2 . ARG A 1 169 ? -7.223  -0.119  5.249  1.00 118.40 ? 201 ARG A NH2 1 ? 
ATOM   1336 N N   . GLY A 1 170 ? -4.810  -6.467  9.939  1.00 60.74  ? 202 GLY A N   1 ? 
ATOM   1337 C CA  . GLY A 1 170 ? -3.514  -6.949  10.388 1.00 65.08  ? 202 GLY A CA  1 ? 
ATOM   1338 C C   . GLY A 1 170 ? -2.581  -5.815  10.805 1.00 67.42  ? 202 GLY A C   1 ? 
ATOM   1339 O O   . GLY A 1 170 ? -1.371  -6.007  10.871 1.00 78.62  ? 202 GLY A O   1 ? 
ATOM   1340 N N   . GLU A 1 171 ? -3.159  -4.651  11.124 1.00 69.14  ? 203 GLU A N   1 ? 
ATOM   1341 C CA  . GLU A 1 171 ? -2.394  -3.513  11.593 1.00 61.69  ? 203 GLU A CA  1 ? 
ATOM   1342 C C   . GLU A 1 171 ? -2.355  -3.542  13.113 1.00 60.96  ? 203 GLU A C   1 ? 
ATOM   1343 O O   . GLU A 1 171 ? -3.291  -4.021  13.738 1.00 69.07  ? 203 GLU A O   1 ? 
ATOM   1344 C CB  . GLU A 1 171 ? -3.007  -2.194  11.132 1.00 62.88  ? 203 GLU A CB  1 ? 
ATOM   1345 C CG  . GLU A 1 171 ? -3.349  -2.180  9.647  1.00 63.27  ? 203 GLU A CG  1 ? 
ATOM   1346 C CD  . GLU A 1 171 ? -3.725  -0.814  9.107  1.00 71.22  ? 203 GLU A CD  1 ? 
ATOM   1347 O OE1 . GLU A 1 171 ? -4.760  -0.236  9.501  1.00 72.29  ? 203 GLU A OE1 1 ? 
ATOM   1348 O OE2 . GLU A 1 171 ? -2.945  -0.332  8.263  1.00 90.58  ? 203 GLU A OE2 1 ? 
ATOM   1349 N N   . ILE A 1 172 ? -1.274  -2.989  13.669 1.00 56.89  ? 204 ILE A N   1 ? 
ATOM   1350 C CA  . ILE A 1 172 ? -0.960  -3.032  15.085 1.00 54.93  ? 204 ILE A CA  1 ? 
ATOM   1351 C C   . ILE A 1 172 ? -0.430  -1.650  15.457 1.00 58.03  ? 204 ILE A C   1 ? 
ATOM   1352 O O   . ILE A 1 172 ? 0.640   -1.268  15.005 1.00 67.91  ? 204 ILE A O   1 ? 
ATOM   1353 C CB  . ILE A 1 172 ? 0.084   -4.132  15.370 1.00 60.28  ? 204 ILE A CB  1 ? 
ATOM   1354 C CG1 . ILE A 1 172 ? -0.391  -5.512  14.940 1.00 58.90  ? 204 ILE A CG1 1 ? 
ATOM   1355 C CG2 . ILE A 1 172 ? 0.514   -4.136  16.836 1.00 61.98  ? 204 ILE A CG2 1 ? 
ATOM   1356 C CD1 . ILE A 1 172 ? 0.729   -6.498  14.718 1.00 61.04  ? 204 ILE A CD1 1 ? 
ATOM   1357 N N   . LYS A 1 173 ? -1.175  -0.894  16.270 1.00 63.24  ? 205 LYS A N   1 ? 
ATOM   1358 C CA  . LYS A 1 173 ? -0.848  0.498   16.515 1.00 58.34  ? 205 LYS A CA  1 ? 
ATOM   1359 C C   . LYS A 1 173 ? -0.871  0.777   18.008 1.00 60.84  ? 205 LYS A C   1 ? 
ATOM   1360 O O   . LYS A 1 173 ? -1.626  0.146   18.735 1.00 69.53  ? 205 LYS A O   1 ? 
ATOM   1361 C CB  . LYS A 1 173 ? -1.855  1.341   15.741 1.00 56.54  ? 205 LYS A CB  1 ? 
ATOM   1362 C CG  . LYS A 1 173 ? -2.046  0.854   14.312 1.00 55.42  ? 205 LYS A CG  1 ? 
ATOM   1363 C CD  . LYS A 1 173 ? -2.797  1.878   13.486 1.00 55.42  ? 205 LYS A CD  1 ? 
ATOM   1364 C CE  . LYS A 1 173 ? -3.155  1.349   12.156 1.00 65.16  ? 205 LYS A CE  1 ? 
ATOM   1365 N NZ  . LYS A 1 173 ? -3.615  2.443   11.304 1.00 69.05  ? 205 LYS A NZ  1 ? 
ATOM   1366 N N   . LEU A 1 174 ? 0.005   1.680   18.453 1.00 66.54  ? 206 LEU A N   1 ? 
ATOM   1367 C CA  . LEU A 1 174 ? -0.018  2.160   19.823 1.00 68.02  ? 206 LEU A CA  1 ? 
ATOM   1368 C C   . LEU A 1 174 ? -1.126  3.199   19.942 1.00 71.65  ? 206 LEU A C   1 ? 
ATOM   1369 O O   . LEU A 1 174 ? -1.341  3.981   19.017 1.00 70.96  ? 206 LEU A O   1 ? 
ATOM   1370 C CB  . LEU A 1 174 ? 1.324   2.769   20.216 1.00 63.05  ? 206 LEU A CB  1 ? 
ATOM   1371 C CG  . LEU A 1 174 ? 2.531   1.841   20.101 1.00 68.23  ? 206 LEU A CG  1 ? 
ATOM   1372 C CD1 . LEU A 1 174 ? 3.800   2.566   20.528 1.00 67.73  ? 206 LEU A CD1 1 ? 
ATOM   1373 C CD2 . LEU A 1 174 ? 2.331   0.577   20.924 1.00 69.68  ? 206 LEU A CD2 1 ? 
ATOM   1374 N N   . CYS A 1 175 ? -1.806  3.218   21.091 1.00 70.43  ? 207 CYS A N   1 ? 
ATOM   1375 C CA  . CYS A 1 175 ? -2.798  4.228   21.392 1.00 74.15  ? 207 CYS A CA  1 ? 
ATOM   1376 C C   . CYS A 1 175 ? -2.313  5.073   22.554 1.00 72.75  ? 207 CYS A C   1 ? 
ATOM   1377 O O   . CYS A 1 175 ? -2.613  6.258   22.613 1.00 106.72 ? 207 CYS A O   1 ? 
ATOM   1378 C CB  . CYS A 1 175 ? -4.152  3.620   21.708 1.00 75.34  ? 207 CYS A CB  1 ? 
ATOM   1379 S SG  . CYS A 1 175 ? -5.414  4.864   22.071 1.00 76.98  ? 207 CYS A SG  1 ? 
ATOM   1380 N N   . ASP A 1 176 ? -1.582  4.466   23.489 1.00 87.78  ? 208 ASP A N   1 ? 
ATOM   1381 C CA  . ASP A 1 176 ? -0.947  5.304   24.490 1.00 113.99 ? 208 ASP A CA  1 ? 
ATOM   1382 C C   . ASP A 1 176 ? -0.681  6.670   23.855 1.00 116.49 ? 208 ASP A C   1 ? 
ATOM   1383 O O   . ASP A 1 176 ? 0.166   6.801   22.969 1.00 118.31 ? 208 ASP A O   1 ? 
ATOM   1384 C CB  . ASP A 1 176 ? 0.312   4.689   25.081 1.00 128.13 ? 208 ASP A CB  1 ? 
ATOM   1385 C CG  . ASP A 1 176 ? 1.000   5.528   26.151 1.00 142.80 ? 208 ASP A CG  1 ? 
ATOM   1386 O OD1 . ASP A 1 176 ? 0.512   6.645   26.445 1.00 141.39 ? 208 ASP A OD1 1 ? 
ATOM   1387 O OD2 . ASP A 1 176 ? 2.022   5.058   26.688 1.00 155.12 ? 208 ASP A OD2 1 ? 
ATOM   1388 N N   . PHE A 1 177 ? -1.462  7.667   24.287 1.00 116.73 ? 209 PHE A N   1 ? 
ATOM   1389 C CA  . PHE A 1 177 ? -1.249  9.054   23.912 1.00 118.68 ? 209 PHE A CA  1 ? 
ATOM   1390 C C   . PHE A 1 177 ? -1.146  9.870   25.197 1.00 125.85 ? 209 PHE A C   1 ? 
ATOM   1391 O O   . PHE A 1 177 ? -1.867  9.599   26.156 1.00 138.75 ? 209 PHE A O   1 ? 
ATOM   1392 C CB  . PHE A 1 177 ? -2.358  9.543   22.976 1.00 115.10 ? 209 PHE A CB  1 ? 
ATOM   1393 C CG  . PHE A 1 177 ? -2.186  9.162   21.509 1.00 119.82 ? 209 PHE A CG  1 ? 
ATOM   1394 C CD1 . PHE A 1 177 ? -1.180  9.731   20.737 1.00 117.92 ? 209 PHE A CD1 1 ? 
ATOM   1395 C CD2 . PHE A 1 177 ? -3.055  8.269   20.887 1.00 124.54 ? 209 PHE A CD2 1 ? 
ATOM   1396 C CE1 . PHE A 1 177 ? -1.036  9.397   19.399 1.00 118.72 ? 209 PHE A CE1 1 ? 
ATOM   1397 C CE2 . PHE A 1 177 ? -2.906  7.941   19.548 1.00 117.10 ? 209 PHE A CE2 1 ? 
ATOM   1398 C CZ  . PHE A 1 177 ? -1.903  8.509   18.807 1.00 114.12 ? 209 PHE A CZ  1 ? 
ATOM   1399 N N   . GLY A 1 178 ? -0.241  10.857  25.203 1.00 124.92 ? 210 GLY A N   1 ? 
ATOM   1400 C CA  . GLY A 1 178 ? 0.136   11.567  26.416 1.00 143.29 ? 210 GLY A CA  1 ? 
ATOM   1401 C C   . GLY A 1 178 ? -1.040  12.314  27.047 1.00 155.07 ? 210 GLY A C   1 ? 
ATOM   1402 O O   . GLY A 1 178 ? -2.093  12.468  26.431 1.00 166.50 ? 210 GLY A O   1 ? 
ATOM   1403 N N   . VAL A 1 179 ? -0.844  12.763  28.293 1.00 154.17 ? 211 VAL A N   1 ? 
ATOM   1404 C CA  . VAL A 1 179 ? -1.837  13.558  29.000 1.00 156.37 ? 211 VAL A CA  1 ? 
ATOM   1405 C C   . VAL A 1 179 ? -1.108  14.638  29.796 1.00 154.90 ? 211 VAL A C   1 ? 
ATOM   1406 O O   . VAL A 1 179 ? -0.012  14.406  30.306 1.00 130.82 ? 211 VAL A O   1 ? 
ATOM   1407 C CB  . VAL A 1 179 ? -2.752  12.746  29.942 1.00 159.00 ? 211 VAL A CB  1 ? 
ATOM   1408 C CG1 . VAL A 1 179 ? -3.299  11.482  29.285 1.00 152.88 ? 211 VAL A CG1 1 ? 
ATOM   1409 C CG2 . VAL A 1 179 ? -2.066  12.411  31.264 1.00 161.09 ? 211 VAL A CG2 1 ? 
ATOM   1410 N N   . SER A 1 180 ? -1.755  15.805  29.907 1.00 158.22 ? 212 SER A N   1 ? 
ATOM   1411 C CA  . SER A 1 180 ? -1.340  16.855  30.823 1.00 151.42 ? 212 SER A CA  1 ? 
ATOM   1412 C C   . SER A 1 180 ? -2.349  17.000  31.963 1.00 146.31 ? 212 SER A C   1 ? 
ATOM   1413 O O   . SER A 1 180 ? -2.159  17.850  32.828 1.00 147.52 ? 212 SER A O   1 ? 
ATOM   1414 C CB  . SER A 1 180 ? -1.171  18.167  30.100 1.00 153.23 ? 212 SER A CB  1 ? 
ATOM   1415 O OG  . SER A 1 180 ? -2.431  18.718  29.742 1.00 151.81 ? 212 SER A OG  1 ? 
ATOM   1416 N N   . GLY A 1 181 ? -3.411  16.176  31.946 1.00 139.16 ? 213 GLY A N   1 ? 
ATOM   1417 C CA  . GLY A 1 181 ? -4.491  16.240  32.920 1.00 143.07 ? 213 GLY A CA  1 ? 
ATOM   1418 C C   . GLY A 1 181 ? -4.105  17.045  34.161 1.00 159.27 ? 213 GLY A C   1 ? 
ATOM   1419 O O   . GLY A 1 181 ? -3.369  16.546  35.012 1.00 161.08 ? 213 GLY A O   1 ? 
ATOM   1420 N N   . GLN A 1 182 ? -4.608  18.291  34.238 1.00 160.82 ? 214 GLN A N   1 ? 
ATOM   1421 C CA  . GLN A 1 182 ? -4.341  19.195  35.351 1.00 149.26 ? 214 GLN A CA  1 ? 
ATOM   1422 C C   . GLN A 1 182 ? -5.017  18.642  36.618 1.00 146.42 ? 214 GLN A C   1 ? 
ATOM   1423 O O   . GLN A 1 182 ? -4.732  17.479  36.977 1.00 153.85 ? 214 GLN A O   1 ? 
ATOM   1424 C CB  . GLN A 1 182 ? -4.895  20.620  35.222 1.00 148.15 ? 214 GLN A CB  1 ? 
ATOM   1425 C CG  . GLN A 1 182 ? -4.779  21.282  33.849 1.00 153.39 ? 214 GLN A CG  1 ? 
ATOM   1426 C CD  . GLN A 1 182 ? -3.372  21.686  33.456 1.00 159.36 ? 214 GLN A CD  1 ? 
ATOM   1427 O OE1 . GLN A 1 182 ? -2.824  21.211  32.455 1.00 168.34 ? 214 GLN A OE1 1 ? 
ATOM   1428 N NE2 . GLN A 1 182 ? -2.777  22.596  34.214 1.00 153.46 ? 214 GLN A NE2 1 ? 
ATOM   1429 N N   . VAL A 1 192 ? -3.870  0.918   38.545 1.00 148.02 ? 224 VAL A N   1 ? 
ATOM   1430 C CA  . VAL A 1 192 ? -2.667  0.258   39.144 1.00 156.45 ? 224 VAL A CA  1 ? 
ATOM   1431 C C   . VAL A 1 192 ? -3.119  -0.634  40.304 1.00 165.60 ? 224 VAL A C   1 ? 
ATOM   1432 O O   . VAL A 1 192 ? -2.993  -0.266  41.472 1.00 163.27 ? 224 VAL A O   1 ? 
ATOM   1433 C CB  . VAL A 1 192 ? -1.608  1.301   39.563 1.00 145.75 ? 224 VAL A CB  1 ? 
ATOM   1434 C CG1 . VAL A 1 192 ? -0.465  0.695   40.372 1.00 143.25 ? 224 VAL A CG1 1 ? 
ATOM   1435 C CG2 . VAL A 1 192 ? -1.048  2.042   38.353 1.00 138.35 ? 224 VAL A CG2 1 ? 
ATOM   1436 N N   . GLY A 1 193 ? -3.658  -1.811  39.953 1.00 166.87 ? 225 GLY A N   1 ? 
ATOM   1437 C CA  . GLY A 1 193 ? -4.092  -2.810  40.919 1.00 158.75 ? 225 GLY A CA  1 ? 
ATOM   1438 C C   . GLY A 1 193 ? -3.368  -4.140  40.712 1.00 154.03 ? 225 GLY A C   1 ? 
ATOM   1439 O O   . GLY A 1 193 ? -3.902  -5.040  40.066 1.00 155.49 ? 225 GLY A O   1 ? 
ATOM   1440 N N   . THR A 1 194 ? -2.143  -4.218  41.260 1.00 148.84 ? 226 THR A N   1 ? 
ATOM   1441 C CA  . THR A 1 194 ? -1.284  -5.402  41.297 1.00 134.23 ? 226 THR A CA  1 ? 
ATOM   1442 C C   . THR A 1 194 ? -0.206  -5.310  40.214 1.00 123.90 ? 226 THR A C   1 ? 
ATOM   1443 O O   . THR A 1 194 ? 0.839   -5.939  40.348 1.00 131.57 ? 226 THR A O   1 ? 
ATOM   1444 C CB  . THR A 1 194 ? -2.029  -6.735  41.175 1.00 126.35 ? 226 THR A CB  1 ? 
ATOM   1445 O OG1 . THR A 1 194 ? -3.266  -6.683  41.879 1.00 129.01 ? 226 THR A OG1 1 ? 
ATOM   1446 C CG2 . THR A 1 194 ? -1.219  -7.886  41.750 1.00 123.05 ? 226 THR A CG2 1 ? 
ATOM   1447 N N   . ARG A 1 195 ? -0.455  -4.551  39.139 1.00 111.68 ? 227 ARG A N   1 ? 
ATOM   1448 C CA  . ARG A 1 195 ? 0.409   -4.585  37.967 1.00 105.71 ? 227 ARG A CA  1 ? 
ATOM   1449 C C   . ARG A 1 195 ? 1.156   -3.260  37.834 1.00 102.05 ? 227 ARG A C   1 ? 
ATOM   1450 O O   . ARG A 1 195 ? 0.561   -2.192  37.951 1.00 107.64 ? 227 ARG A O   1 ? 
ATOM   1451 C CB  . ARG A 1 195 ? -0.409  -4.881  36.703 1.00 97.86  ? 227 ARG A CB  1 ? 
ATOM   1452 C CG  . ARG A 1 195 ? -1.048  -6.262  36.672 1.00 98.02  ? 227 ARG A CG  1 ? 
ATOM   1453 C CD  . ARG A 1 195 ? -2.397  -6.297  35.974 1.00 104.92 ? 227 ARG A CD  1 ? 
ATOM   1454 N NE  . ARG A 1 195 ? -2.315  -5.947  34.552 1.00 108.14 ? 227 ARG A NE  1 ? 
ATOM   1455 C CZ  . ARG A 1 195 ? -2.584  -6.750  33.524 1.00 121.73 ? 227 ARG A CZ  1 ? 
ATOM   1456 N NH1 . ARG A 1 195 ? -2.499  -6.285  32.286 1.00 130.41 ? 227 ARG A NH1 1 ? 
ATOM   1457 N NH2 . ARG A 1 195 ? -2.935  -8.013  33.720 1.00 120.28 ? 227 ARG A NH2 1 ? 
ATOM   1458 N N   . SER A 1 196 ? 2.467   -3.359  37.594 1.00 90.58  ? 228 SER A N   1 ? 
ATOM   1459 C CA  . SER A 1 196 ? 3.297   -2.218  37.256 1.00 87.61  ? 228 SER A CA  1 ? 
ATOM   1460 C C   . SER A 1 196 ? 4.167   -2.551  36.046 1.00 83.32  ? 228 SER A C   1 ? 
ATOM   1461 O O   . SER A 1 196 ? 4.761   -3.628  35.998 1.00 81.59  ? 228 SER A O   1 ? 
ATOM   1462 C CB  . SER A 1 196 ? 4.152   -1.817  38.425 1.00 88.79  ? 228 SER A CB  1 ? 
ATOM   1463 O OG  . SER A 1 196 ? 5.076   -0.804  38.052 1.00 86.31  ? 228 SER A OG  1 ? 
ATOM   1464 N N   . TYR A 1 197 ? 4.267   -1.600  35.103 1.00 81.43  ? 229 TYR A N   1 ? 
ATOM   1465 C CA  . TYR A 1 197 ? 5.080   -1.752  33.904 1.00 79.19  ? 229 TYR A CA  1 ? 
ATOM   1466 C C   . TYR A 1 197 ? 6.271   -0.798  33.961 1.00 84.18  ? 229 TYR A C   1 ? 
ATOM   1467 O O   . TYR A 1 197 ? 6.912   -0.529  32.945 1.00 84.33  ? 229 TYR A O   1 ? 
ATOM   1468 C CB  . TYR A 1 197 ? 4.204   -1.543  32.663 1.00 76.87  ? 229 TYR A CB  1 ? 
ATOM   1469 C CG  . TYR A 1 197 ? 3.104   -2.588  32.497 1.00 74.19  ? 229 TYR A CG  1 ? 
ATOM   1470 C CD1 . TYR A 1 197 ? 1.857   -2.415  33.084 1.00 71.68  ? 229 TYR A CD1 1 ? 
ATOM   1471 C CD2 . TYR A 1 197 ? 3.317   -3.758  31.775 1.00 72.75  ? 229 TYR A CD2 1 ? 
ATOM   1472 C CE1 . TYR A 1 197 ? 0.853   -3.361  32.949 1.00 68.13  ? 229 TYR A CE1 1 ? 
ATOM   1473 C CE2 . TYR A 1 197 ? 2.319   -4.707  31.623 1.00 72.83  ? 229 TYR A CE2 1 ? 
ATOM   1474 C CZ  . TYR A 1 197 ? 1.080   -4.509  32.211 1.00 69.59  ? 229 TYR A CZ  1 ? 
ATOM   1475 O OH  . TYR A 1 197 ? 0.078   -5.437  32.095 1.00 61.82  ? 229 TYR A OH  1 ? 
ATOM   1476 N N   . MET A 1 198 ? 6.581   -0.317  35.170 1.00 88.07  ? 230 MET A N   1 ? 
ATOM   1477 C CA  . MET A 1 198 ? 7.650   0.645   35.368 1.00 90.44  ? 230 MET A CA  1 ? 
ATOM   1478 C C   . MET A 1 198 ? 8.984   -0.093  35.352 1.00 84.82  ? 230 MET A C   1 ? 
ATOM   1479 O O   . MET A 1 198 ? 9.156   -1.100  36.033 1.00 82.90  ? 230 MET A O   1 ? 
ATOM   1480 C CB  . MET A 1 198 ? 7.517   1.359   36.719 1.00 105.53 ? 230 MET A CB  1 ? 
ATOM   1481 C CG  . MET A 1 198 ? 7.480   2.874   36.635 1.00 114.54 ? 230 MET A CG  1 ? 
ATOM   1482 S SD  . MET A 1 198 ? 5.798   3.512   36.786 1.00 136.29 ? 230 MET A SD  1 ? 
ATOM   1483 C CE  . MET A 1 198 ? 4.906   2.645   35.486 1.00 141.01 ? 230 MET A CE  1 ? 
ATOM   1484 N N   . SER A 1 199 ? 9.933   0.436   34.582 1.00 85.53  ? 231 SER A N   1 ? 
ATOM   1485 C CA  . SER A 1 199 ? 11.274  -0.111  34.555 1.00 91.47  ? 231 SER A CA  1 ? 
ATOM   1486 C C   . SER A 1 199 ? 11.902  0.018   35.939 1.00 89.23  ? 231 SER A C   1 ? 
ATOM   1487 O O   . SER A 1 199 ? 11.520  0.899   36.706 1.00 93.26  ? 231 SER A O   1 ? 
ATOM   1488 C CB  . SER A 1 199 ? 12.112  0.556   33.491 1.00 101.04 ? 231 SER A CB  1 ? 
ATOM   1489 O OG  . SER A 1 199 ? 12.105  1.971   33.625 1.00 102.57 ? 231 SER A OG  1 ? 
ATOM   1490 N N   . PRO A 1 200 ? 12.880  -0.848  36.299 1.00 92.08  ? 232 PRO A N   1 ? 
ATOM   1491 C CA  . PRO A 1 200 ? 13.526  -0.780  37.608 1.00 96.66  ? 232 PRO A CA  1 ? 
ATOM   1492 C C   . PRO A 1 200 ? 14.091  0.612   37.873 1.00 97.44  ? 232 PRO A C   1 ? 
ATOM   1493 O O   . PRO A 1 200 ? 13.980  1.123   38.983 1.00 101.98 ? 232 PRO A O   1 ? 
ATOM   1494 C CB  . PRO A 1 200 ? 14.641  -1.847  37.551 1.00 96.45  ? 232 PRO A CB  1 ? 
ATOM   1495 C CG  . PRO A 1 200 ? 14.255  -2.759  36.410 1.00 91.74  ? 232 PRO A CG  1 ? 
ATOM   1496 C CD  . PRO A 1 200 ? 13.450  -1.905  35.451 1.00 92.62  ? 232 PRO A CD  1 ? 
ATOM   1497 N N   . GLU A 1 201 ? 14.688  1.213   36.835 1.00 104.27 ? 233 GLU A N   1 ? 
ATOM   1498 C CA  . GLU A 1 201 ? 15.426  2.459   36.977 1.00 98.36  ? 233 GLU A CA  1 ? 
ATOM   1499 C C   . GLU A 1 201 ? 14.468  3.592   37.339 1.00 93.21  ? 233 GLU A C   1 ? 
ATOM   1500 O O   . GLU A 1 201 ? 14.842  4.471   38.110 1.00 102.21 ? 233 GLU A O   1 ? 
ATOM   1501 C CB  . GLU A 1 201 ? 16.284  2.782   35.747 1.00 98.27  ? 233 GLU A CB  1 ? 
ATOM   1502 C CG  . GLU A 1 201 ? 15.513  3.044   34.453 1.00 102.78 ? 233 GLU A CG  1 ? 
ATOM   1503 C CD  . GLU A 1 201 ? 15.249  1.853   33.546 1.00 106.73 ? 233 GLU A CD  1 ? 
ATOM   1504 O OE1 . GLU A 1 201 ? 15.688  0.720   33.856 1.00 98.52  ? 233 GLU A OE1 1 ? 
ATOM   1505 O OE2 . GLU A 1 201 ? 14.590  2.071   32.502 1.00 105.04 ? 233 GLU A OE2 1 ? 
ATOM   1506 N N   . ARG A 1 202 ? 13.232  3.543   36.820 1.00 96.12  ? 234 ARG A N   1 ? 
ATOM   1507 C CA  . ARG A 1 202 ? 12.259  4.610   37.029 1.00 104.66 ? 234 ARG A CA  1 ? 
ATOM   1508 C C   . ARG A 1 202 ? 11.420  4.322   38.275 1.00 101.92 ? 234 ARG A C   1 ? 
ATOM   1509 O O   . ARG A 1 202 ? 10.509  5.082   38.592 1.00 111.45 ? 234 ARG A O   1 ? 
ATOM   1510 C CB  . ARG A 1 202 ? 11.381  4.855   35.791 1.00 113.87 ? 234 ARG A CB  1 ? 
ATOM   1511 C CG  . ARG A 1 202 ? 10.661  6.201   35.781 1.00 130.89 ? 234 ARG A CG  1 ? 
ATOM   1512 C CD  . ARG A 1 202 ? 10.345  6.795   34.399 1.00 141.63 ? 234 ARG A CD  1 ? 
ATOM   1513 N NE  . ARG A 1 202 ? 9.009   6.505   33.859 1.00 145.40 ? 234 ARG A NE  1 ? 
ATOM   1514 C CZ  . ARG A 1 202 ? 8.592   5.358   33.327 1.00 147.86 ? 234 ARG A CZ  1 ? 
ATOM   1515 N NH1 . ARG A 1 202 ? 9.405   4.319   33.230 1.00 150.84 ? 234 ARG A NH1 1 ? 
ATOM   1516 N NH2 . ARG A 1 202 ? 7.352   5.255   32.877 1.00 148.22 ? 234 ARG A NH2 1 ? 
ATOM   1517 N N   . LEU A 1 203 ? 11.733  3.229   38.981 1.00 98.50  ? 235 LEU A N   1 ? 
ATOM   1518 C CA  . LEU A 1 203 ? 11.217  3.007   40.321 1.00 101.02 ? 235 LEU A CA  1 ? 
ATOM   1519 C C   . LEU A 1 203 ? 12.247  3.486   41.345 1.00 117.32 ? 235 LEU A C   1 ? 
ATOM   1520 O O   . LEU A 1 203 ? 12.200  3.086   42.505 1.00 121.96 ? 235 LEU A O   1 ? 
ATOM   1521 C CB  . LEU A 1 203 ? 10.878  1.525   40.490 1.00 102.32 ? 235 LEU A CB  1 ? 
ATOM   1522 C CG  . LEU A 1 203 ? 9.673   1.017   39.690 1.00 101.08 ? 235 LEU A CG  1 ? 
ATOM   1523 C CD1 . LEU A 1 203 ? 9.554   -0.506  39.707 1.00 93.21  ? 235 LEU A CD1 1 ? 
ATOM   1524 C CD2 . LEU A 1 203 ? 8.398   1.650   40.231 1.00 100.91 ? 235 LEU A CD2 1 ? 
ATOM   1525 N N   . GLN A 1 204 ? 13.175  4.345   40.895 1.00 133.31 ? 236 GLN A N   1 ? 
ATOM   1526 C CA  . GLN A 1 204 ? 14.198  4.942   41.741 1.00 132.37 ? 236 GLN A CA  1 ? 
ATOM   1527 C C   . GLN A 1 204 ? 14.500  6.369   41.248 1.00 133.60 ? 236 GLN A C   1 ? 
ATOM   1528 O O   . GLN A 1 204 ? 13.609  7.236   41.391 1.00 131.14 ? 236 GLN A O   1 ? 
ATOM   1529 C CB  . GLN A 1 204 ? 15.503  4.146   41.693 1.00 128.81 ? 236 GLN A CB  1 ? 
ATOM   1530 C CG  . GLN A 1 204 ? 15.361  2.671   42.059 1.00 134.15 ? 236 GLN A CG  1 ? 
ATOM   1531 C CD  . GLN A 1 204 ? 16.608  1.857   41.777 1.00 142.93 ? 236 GLN A CD  1 ? 
ATOM   1532 O OE1 . GLN A 1 204 ? 17.571  1.860   42.552 1.00 156.32 ? 236 GLN A OE1 1 ? 
ATOM   1533 N NE2 . GLN A 1 204 ? 16.597  1.126   40.671 1.00 138.40 ? 236 GLN A NE2 1 ? 
ATOM   1534 N N   . TYR A 1 208 ? 13.866  9.500   31.443 1.00 173.82 ? 240 TYR A N   1 ? 
ATOM   1535 C CA  . TYR A 1 208 ? 12.797  8.803   30.668 1.00 172.78 ? 240 TYR A CA  1 ? 
ATOM   1536 C C   . TYR A 1 208 ? 13.446  7.958   29.565 1.00 163.17 ? 240 TYR A C   1 ? 
ATOM   1537 O O   . TYR A 1 208 ? 14.112  6.972   29.878 1.00 168.62 ? 240 TYR A O   1 ? 
ATOM   1538 C CB  . TYR A 1 208 ? 11.727  9.827   30.255 1.00 176.81 ? 240 TYR A CB  1 ? 
ATOM   1539 C CG  . TYR A 1 208 ? 12.180  11.187  29.731 1.00 177.05 ? 240 TYR A CG  1 ? 
ATOM   1540 C CD1 . TYR A 1 208 ? 13.313  11.326  28.933 1.00 174.02 ? 240 TYR A CD1 1 ? 
ATOM   1541 C CD2 . TYR A 1 208 ? 11.458  12.338  30.034 1.00 166.88 ? 240 TYR A CD2 1 ? 
ATOM   1542 C CE1 . TYR A 1 208 ? 13.714  12.561  28.455 1.00 169.00 ? 240 TYR A CE1 1 ? 
ATOM   1543 C CE2 . TYR A 1 208 ? 11.849  13.580  29.561 1.00 166.88 ? 240 TYR A CE2 1 ? 
ATOM   1544 C CZ  . TYR A 1 208 ? 12.980  13.689  28.769 1.00 169.41 ? 240 TYR A CZ  1 ? 
ATOM   1545 O OH  . TYR A 1 208 ? 13.402  14.888  28.277 1.00 172.40 ? 240 TYR A OH  1 ? 
ATOM   1546 N N   . SER A 1 209 ? 13.217  8.308   28.289 1.00 144.98 ? 241 SER A N   1 ? 
ATOM   1547 C CA  . SER A 1 209 ? 13.881  7.685   27.149 1.00 133.08 ? 241 SER A CA  1 ? 
ATOM   1548 C C   . SER A 1 209 ? 13.274  6.314   26.846 1.00 126.98 ? 241 SER A C   1 ? 
ATOM   1549 O O   . SER A 1 209 ? 12.533  5.754   27.655 1.00 114.82 ? 241 SER A O   1 ? 
ATOM   1550 C CB  . SER A 1 209 ? 15.385  7.591   27.340 1.00 127.74 ? 241 SER A CB  1 ? 
ATOM   1551 O OG  . SER A 1 209 ? 15.756  6.456   28.111 1.00 124.89 ? 241 SER A OG  1 ? 
ATOM   1552 N N   . VAL A 1 210 ? 13.634  5.769   25.674 1.00 113.78 ? 242 VAL A N   1 ? 
ATOM   1553 C CA  . VAL A 1 210 ? 13.031  4.552   25.152 1.00 103.65 ? 242 VAL A CA  1 ? 
ATOM   1554 C C   . VAL A 1 210 ? 13.398  3.344   26.016 1.00 101.02 ? 242 VAL A C   1 ? 
ATOM   1555 O O   . VAL A 1 210 ? 12.649  2.372   26.027 1.00 96.43  ? 242 VAL A O   1 ? 
ATOM   1556 C CB  . VAL A 1 210 ? 13.391  4.259   23.681 1.00 101.69 ? 242 VAL A CB  1 ? 
ATOM   1557 C CG1 . VAL A 1 210 ? 12.964  5.388   22.756 1.00 102.77 ? 242 VAL A CG1 1 ? 
ATOM   1558 C CG2 . VAL A 1 210 ? 14.869  3.935   23.498 1.00 106.00 ? 242 VAL A CG2 1 ? 
ATOM   1559 N N   . GLN A 1 211 ? 14.540  3.391   26.718 1.00 96.38  ? 243 GLN A N   1 ? 
ATOM   1560 C CA  . GLN A 1 211 ? 15.010  2.251   27.494 1.00 94.05  ? 243 GLN A CA  1 ? 
ATOM   1561 C C   . GLN A 1 211 ? 13.933  1.765   28.467 1.00 95.00  ? 243 GLN A C   1 ? 
ATOM   1562 O O   . GLN A 1 211 ? 13.847  0.566   28.719 1.00 105.41 ? 243 GLN A O   1 ? 
ATOM   1563 C CB  . GLN A 1 211 ? 16.330  2.527   28.222 1.00 90.86  ? 243 GLN A CB  1 ? 
ATOM   1564 C CG  . GLN A 1 211 ? 17.551  2.578   27.306 1.00 101.84 ? 243 GLN A CG  1 ? 
ATOM   1565 C CD  . GLN A 1 211 ? 17.613  1.452   26.291 1.00 108.15 ? 243 GLN A CD  1 ? 
ATOM   1566 O OE1 . GLN A 1 211 ? 17.249  1.625   25.121 1.00 102.00 ? 243 GLN A OE1 1 ? 
ATOM   1567 N NE2 . GLN A 1 211 ? 18.060  0.281   26.725 1.00 107.42 ? 243 GLN A NE2 1 ? 
ATOM   1568 N N   . SER A 1 212 ? 13.120  2.678   29.013 1.00 91.81  ? 244 SER A N   1 ? 
ATOM   1569 C CA  . SER A 1 212 ? 12.021  2.290   29.886 1.00 91.51  ? 244 SER A CA  1 ? 
ATOM   1570 C C   . SER A 1 212 ? 10.925  1.580   29.084 1.00 82.91  ? 244 SER A C   1 ? 
ATOM   1571 O O   . SER A 1 212 ? 10.279  0.652   29.568 1.00 70.12  ? 244 SER A O   1 ? 
ATOM   1572 C CB  . SER A 1 212 ? 11.474  3.486   30.624 1.00 103.28 ? 244 SER A CB  1 ? 
ATOM   1573 O OG  . SER A 1 212 ? 10.897  4.421   29.720 1.00 122.68 ? 244 SER A OG  1 ? 
ATOM   1574 N N   . ASP A 1 213 ? 10.711  2.013   27.840 1.00 75.26  ? 245 ASP A N   1 ? 
ATOM   1575 C CA  . ASP A 1 213 ? 9.626   1.467   27.045 1.00 76.16  ? 245 ASP A CA  1 ? 
ATOM   1576 C C   . ASP A 1 213 ? 10.000  0.081   26.538 1.00 68.31  ? 245 ASP A C   1 ? 
ATOM   1577 O O   . ASP A 1 213 ? 9.146   -0.790  26.432 1.00 75.86  ? 245 ASP A O   1 ? 
ATOM   1578 C CB  . ASP A 1 213 ? 9.183   2.452   25.981 1.00 86.19  ? 245 ASP A CB  1 ? 
ATOM   1579 C CG  . ASP A 1 213 ? 8.625   3.743   26.561 1.00 95.32  ? 245 ASP A CG  1 ? 
ATOM   1580 O OD1 . ASP A 1 213 ? 9.435   4.648   26.847 1.00 112.55 ? 245 ASP A OD1 1 ? 
ATOM   1581 O OD2 . ASP A 1 213 ? 7.399   3.796   26.797 1.00 95.43  ? 245 ASP A OD2 1 ? 
ATOM   1582 N N   . ILE A 1 214 ? 11.290  -0.124  26.275 1.00 74.48  ? 246 ILE A N   1 ? 
ATOM   1583 C CA  . ILE A 1 214 ? 11.802  -1.424  25.889 1.00 70.94  ? 246 ILE A CA  1 ? 
ATOM   1584 C C   . ILE A 1 214 ? 11.538  -2.418  27.019 1.00 71.58  ? 246 ILE A C   1 ? 
ATOM   1585 O O   . ILE A 1 214 ? 11.106  -3.536  26.756 1.00 78.52  ? 246 ILE A O   1 ? 
ATOM   1586 C CB  . ILE A 1 214 ? 13.283  -1.318  25.475 1.00 72.82  ? 246 ILE A CB  1 ? 
ATOM   1587 C CG1 . ILE A 1 214 ? 13.410  -0.500  24.179 1.00 83.20  ? 246 ILE A CG1 1 ? 
ATOM   1588 C CG2 . ILE A 1 214 ? 13.937  -2.695  25.333 1.00 70.61  ? 246 ILE A CG2 1 ? 
ATOM   1589 C CD1 . ILE A 1 214 ? 14.836  -0.178  23.767 1.00 88.08  ? 246 ILE A CD1 1 ? 
ATOM   1590 N N   . TRP A 1 215 ? 11.755  -2.006  28.273 1.00 67.67  ? 247 TRP A N   1 ? 
ATOM   1591 C CA  . TRP A 1 215 ? 11.402  -2.848  29.406 1.00 66.82  ? 247 TRP A CA  1 ? 
ATOM   1592 C C   . TRP A 1 215 ? 9.920   -3.231  29.390 1.00 68.09  ? 247 TRP A C   1 ? 
ATOM   1593 O O   . TRP A 1 215 ? 9.600   -4.405  29.554 1.00 70.39  ? 247 TRP A O   1 ? 
ATOM   1594 C CB  . TRP A 1 215 ? 11.762  -2.146  30.717 1.00 68.47  ? 247 TRP A CB  1 ? 
ATOM   1595 C CG  . TRP A 1 215 ? 11.192  -2.791  31.950 1.00 66.00  ? 247 TRP A CG  1 ? 
ATOM   1596 C CD1 . TRP A 1 215 ? 9.982   -2.547  32.529 1.00 63.45  ? 247 TRP A CD1 1 ? 
ATOM   1597 C CD2 . TRP A 1 215 ? 11.853  -3.759  32.792 1.00 73.67  ? 247 TRP A CD2 1 ? 
ATOM   1598 N NE1 . TRP A 1 215 ? 9.830   -3.306  33.662 1.00 69.48  ? 247 TRP A NE1 1 ? 
ATOM   1599 C CE2 . TRP A 1 215 ? 10.959  -4.058  33.850 1.00 65.82  ? 247 TRP A CE2 1 ? 
ATOM   1600 C CE3 . TRP A 1 215 ? 13.102  -4.396  32.751 1.00 76.11  ? 247 TRP A CE3 1 ? 
ATOM   1601 C CZ2 . TRP A 1 215 ? 11.282  -4.963  34.858 1.00 70.71  ? 247 TRP A CZ2 1 ? 
ATOM   1602 C CZ3 . TRP A 1 215 ? 13.422  -5.290  33.751 1.00 77.21  ? 247 TRP A CZ3 1 ? 
ATOM   1603 C CH2 . TRP A 1 215 ? 12.527  -5.558  34.795 1.00 82.49  ? 247 TRP A CH2 1 ? 
ATOM   1604 N N   . SER A 1 216 ? 9.022   -2.246  29.228 1.00 65.82  ? 248 SER A N   1 ? 
ATOM   1605 C CA  . SER A 1 216 ? 7.589   -2.499  29.322 1.00 67.76  ? 248 SER A CA  1 ? 
ATOM   1606 C C   . SER A 1 216 ? 7.160   -3.497  28.247 1.00 68.05  ? 248 SER A C   1 ? 
ATOM   1607 O O   . SER A 1 216 ? 6.426   -4.451  28.506 1.00 63.15  ? 248 SER A O   1 ? 
ATOM   1608 C CB  . SER A 1 216 ? 6.784   -1.231  29.185 1.00 69.69  ? 248 SER A CB  1 ? 
ATOM   1609 O OG  . SER A 1 216 ? 7.380   -0.156  29.891 1.00 85.40  ? 248 SER A OG  1 ? 
ATOM   1610 N N   . MET A 1 217 ? 7.615   -3.241  27.022 1.00 58.23  ? 249 MET A N   1 ? 
ATOM   1611 C CA  . MET A 1 217 ? 7.299   -4.108  25.903 1.00 64.75  ? 249 MET A CA  1 ? 
ATOM   1612 C C   . MET A 1 217 ? 7.737   -5.534  26.224 1.00 68.45  ? 249 MET A C   1 ? 
ATOM   1613 O O   . MET A 1 217 ? 7.001   -6.480  25.971 1.00 67.06  ? 249 MET A O   1 ? 
ATOM   1614 C CB  . MET A 1 217 ? 8.012   -3.641  24.631 1.00 62.49  ? 249 MET A CB  1 ? 
ATOM   1615 C CG  . MET A 1 217 ? 7.959   -4.661  23.546 1.00 65.73  ? 249 MET A CG  1 ? 
ATOM   1616 S SD  . MET A 1 217 ? 8.699   -4.046  22.029 1.00 74.06  ? 249 MET A SD  1 ? 
ATOM   1617 C CE  . MET A 1 217 ? 10.407  -4.351  22.502 1.00 74.56  ? 249 MET A CE  1 ? 
ATOM   1618 N N   . GLY A 1 218 ? 8.944   -5.670  26.782 1.00 67.08  ? 250 GLY A N   1 ? 
ATOM   1619 C CA  . GLY A 1 218 ? 9.457   -6.963  27.204 1.00 68.40  ? 250 GLY A CA  1 ? 
ATOM   1620 C C   . GLY A 1 218 ? 8.560   -7.618  28.253 1.00 66.84  ? 250 GLY A C   1 ? 
ATOM   1621 O O   . GLY A 1 218 ? 8.274   -8.815  28.177 1.00 62.19  ? 250 GLY A O   1 ? 
ATOM   1622 N N   . LEU A 1 219 ? 8.134   -6.832  29.245 1.00 58.27  ? 251 LEU A N   1 ? 
ATOM   1623 C CA  . LEU A 1 219 ? 7.247   -7.351  30.273 1.00 62.54  ? 251 LEU A CA  1 ? 
ATOM   1624 C C   . LEU A 1 219 ? 5.909   -7.751  29.644 1.00 68.29  ? 251 LEU A C   1 ? 
ATOM   1625 O O   . LEU A 1 219 ? 5.390   -8.830  29.931 1.00 73.85  ? 251 LEU A O   1 ? 
ATOM   1626 C CB  . LEU A 1 219 ? 7.088   -6.294  31.360 1.00 64.04  ? 251 LEU A CB  1 ? 
ATOM   1627 C CG  . LEU A 1 219 ? 6.313   -6.714  32.607 1.00 68.95  ? 251 LEU A CG  1 ? 
ATOM   1628 C CD1 . LEU A 1 219 ? 7.012   -7.802  33.390 1.00 75.29  ? 251 LEU A CD1 1 ? 
ATOM   1629 C CD2 . LEU A 1 219 ? 6.119   -5.500  33.467 1.00 75.42  ? 251 LEU A CD2 1 ? 
ATOM   1630 N N   . SER A 1 220 ? 5.382   -6.893  28.758 1.00 60.28  ? 252 SER A N   1 ? 
ATOM   1631 C CA  . SER A 1 220 ? 4.125   -7.139  28.062 1.00 66.11  ? 252 SER A CA  1 ? 
ATOM   1632 C C   . SER A 1 220 ? 4.177   -8.382  27.164 1.00 60.37  ? 252 SER A C   1 ? 
ATOM   1633 O O   . SER A 1 220 ? 3.199   -9.122  27.065 1.00 61.29  ? 252 SER A O   1 ? 
ATOM   1634 C CB  . SER A 1 220 ? 3.704   -5.912  27.288 1.00 69.22  ? 252 SER A CB  1 ? 
ATOM   1635 O OG  . SER A 1 220 ? 3.507   -4.803  28.161 1.00 65.97  ? 252 SER A OG  1 ? 
ATOM   1636 N N   . LEU A 1 221 ? 5.312   -8.638  26.514 1.00 55.88  ? 253 LEU A N   1 ? 
ATOM   1637 C CA  . LEU A 1 221 ? 5.436   -9.822  25.682 1.00 60.92  ? 253 LEU A CA  1 ? 
ATOM   1638 C C   . LEU A 1 221 ? 5.341   -11.085 26.538 1.00 62.01  ? 253 LEU A C   1 ? 
ATOM   1639 O O   . LEU A 1 221 ? 4.684   -12.051 26.147 1.00 57.58  ? 253 LEU A O   1 ? 
ATOM   1640 C CB  . LEU A 1 221 ? 6.742   -9.757  24.893 1.00 62.74  ? 253 LEU A CB  1 ? 
ATOM   1641 C CG  . LEU A 1 221 ? 6.705   -8.811  23.693 1.00 64.06  ? 253 LEU A CG  1 ? 
ATOM   1642 C CD1 . LEU A 1 221 ? 8.096   -8.487  23.192 1.00 69.17  ? 253 LEU A CD1 1 ? 
ATOM   1643 C CD2 . LEU A 1 221 ? 5.864   -9.429  22.592 1.00 70.12  ? 253 LEU A CD2 1 ? 
ATOM   1644 N N   . VAL A 1 222 ? 6.007   -11.078 27.700 1.00 60.96  ? 254 VAL A N   1 ? 
ATOM   1645 C CA  . VAL A 1 222 ? 5.896   -12.176 28.650 1.00 59.35  ? 254 VAL A CA  1 ? 
ATOM   1646 C C   . VAL A 1 222 ? 4.430   -12.327 29.060 1.00 55.81  ? 254 VAL A C   1 ? 
ATOM   1647 O O   . VAL A 1 222 ? 3.874   -13.423 28.995 1.00 60.02  ? 254 VAL A O   1 ? 
ATOM   1648 C CB  . VAL A 1 222 ? 6.807   -12.022 29.882 1.00 55.77  ? 254 VAL A CB  1 ? 
ATOM   1649 C CG1 . VAL A 1 222 ? 6.554   -13.117 30.907 1.00 57.07  ? 254 VAL A CG1 1 ? 
ATOM   1650 C CG2 . VAL A 1 222 ? 8.276   -12.022 29.488 1.00 59.77  ? 254 VAL A CG2 1 ? 
ATOM   1651 N N   . GLU A 1 223 ? 3.800   -11.216 29.439 1.00 57.54  ? 255 GLU A N   1 ? 
ATOM   1652 C CA  . GLU A 1 223 ? 2.412   -11.245 29.858 1.00 57.14  ? 255 GLU A CA  1 ? 
ATOM   1653 C C   . GLU A 1 223 ? 1.572   -11.919 28.775 1.00 56.95  ? 255 GLU A C   1 ? 
ATOM   1654 O O   . GLU A 1 223 ? 0.852   -12.869 29.047 1.00 57.34  ? 255 GLU A O   1 ? 
ATOM   1655 C CB  . GLU A 1 223 ? 1.935   -9.839  30.210 1.00 56.87  ? 255 GLU A CB  1 ? 
ATOM   1656 C CG  . GLU A 1 223 ? 0.495   -9.833  30.720 1.00 66.94  ? 255 GLU A CG  1 ? 
ATOM   1657 C CD  . GLU A 1 223 ? -0.004  -8.483  31.193 1.00 69.21  ? 255 GLU A CD  1 ? 
ATOM   1658 O OE1 . GLU A 1 223 ? 0.802   -7.542  31.114 1.00 74.37  ? 255 GLU A OE1 1 ? 
ATOM   1659 O OE2 . GLU A 1 223 ? -1.172  -8.359  31.623 1.00 80.86  ? 255 GLU A OE2 1 ? 
ATOM   1660 N N   . MET A 1 224 ? 1.698   -11.457 27.533 1.00 57.11  ? 256 MET A N   1 ? 
ATOM   1661 C CA  . MET A 1 224 ? 0.831   -11.932 26.467 1.00 57.93  ? 256 MET A CA  1 ? 
ATOM   1662 C C   . MET A 1 224 ? 1.182   -13.365 26.065 1.00 60.97  ? 256 MET A C   1 ? 
ATOM   1663 O O   . MET A 1 224 ? 0.304   -14.095 25.592 1.00 56.06  ? 256 MET A O   1 ? 
ATOM   1664 C CB  . MET A 1 224 ? 0.898   -10.975 25.272 1.00 53.25  ? 256 MET A CB  1 ? 
ATOM   1665 C CG  . MET A 1 224 ? 0.242   -9.650  25.581 1.00 58.11  ? 256 MET A CG  1 ? 
ATOM   1666 S SD  . MET A 1 224 ? 0.209   -8.528  24.176 1.00 60.01  ? 256 MET A SD  1 ? 
ATOM   1667 C CE  . MET A 1 224 ? 1.926   -7.998  24.189 1.00 62.86  ? 256 MET A CE  1 ? 
ATOM   1668 N N   . ALA A 1 225 ? 2.456   -13.759 26.250 1.00 58.70  ? 257 ALA A N   1 ? 
ATOM   1669 C CA  . ALA A 1 225 ? 2.917   -15.090 25.873 1.00 58.19  ? 257 ALA A CA  1 ? 
ATOM   1670 C C   . ALA A 1 225 ? 2.445   -16.154 26.863 1.00 54.40  ? 257 ALA A C   1 ? 
ATOM   1671 O O   . ALA A 1 225 ? 2.209   -17.288 26.470 1.00 45.15  ? 257 ALA A O   1 ? 
ATOM   1672 C CB  . ALA A 1 225 ? 4.428   -15.109 25.775 1.00 56.72  ? 257 ALA A CB  1 ? 
ATOM   1673 N N   . VAL A 1 226 ? 2.379   -15.816 28.157 1.00 51.47  ? 258 VAL A N   1 ? 
ATOM   1674 C CA  . VAL A 1 226 ? 2.074   -16.818 29.164 1.00 56.03  ? 258 VAL A CA  1 ? 
ATOM   1675 C C   . VAL A 1 226 ? 0.615   -16.711 29.594 1.00 61.82  ? 258 VAL A C   1 ? 
ATOM   1676 O O   . VAL A 1 226 ? 0.041   -17.692 30.057 1.00 71.91  ? 258 VAL A O   1 ? 
ATOM   1677 C CB  . VAL A 1 226 ? 3.010   -16.738 30.380 1.00 56.62  ? 258 VAL A CB  1 ? 
ATOM   1678 C CG1 . VAL A 1 226 ? 4.456   -16.938 29.952 1.00 60.12  ? 258 VAL A CG1 1 ? 
ATOM   1679 C CG2 . VAL A 1 226 ? 2.832   -15.448 31.172 1.00 59.68  ? 258 VAL A CG2 1 ? 
ATOM   1680 N N   . GLY A 1 227 ? 0.044   -15.512 29.471 1.00 64.29  ? 259 GLY A N   1 ? 
ATOM   1681 C CA  . GLY A 1 227 ? -1.380  -15.306 29.673 1.00 69.25  ? 259 GLY A CA  1 ? 
ATOM   1682 C C   . GLY A 1 227 ? -1.678  -14.732 31.050 1.00 64.82  ? 259 GLY A C   1 ? 
ATOM   1683 O O   . GLY A 1 227 ? -2.788  -14.864 31.548 1.00 73.71  ? 259 GLY A O   1 ? 
ATOM   1684 N N   . ARG A 1 228 ? -0.692  -14.049 31.627 1.00 70.22  ? 260 ARG A N   1 ? 
ATOM   1685 C CA  . ARG A 1 228 ? -0.725  -13.692 33.033 1.00 79.52  ? 260 ARG A CA  1 ? 
ATOM   1686 C C   . ARG A 1 228 ? 0.393   -12.681 33.284 1.00 74.70  ? 260 ARG A C   1 ? 
ATOM   1687 O O   . ARG A 1 228 ? 1.497   -12.836 32.759 1.00 79.98  ? 260 ARG A O   1 ? 
ATOM   1688 C CB  . ARG A 1 228 ? -0.594  -15.023 33.787 1.00 86.86  ? 260 ARG A CB  1 ? 
ATOM   1689 C CG  . ARG A 1 228 ? -0.395  -14.953 35.292 1.00 97.44  ? 260 ARG A CG  1 ? 
ATOM   1690 C CD  . ARG A 1 228 ? 0.412   -16.151 35.792 1.00 106.43 ? 260 ARG A CD  1 ? 
ATOM   1691 N NE  . ARG A 1 228 ? 0.639   -16.127 37.244 1.00 116.03 ? 260 ARG A NE  1 ? 
ATOM   1692 C CZ  . ARG A 1 228 ? 1.482   -15.338 37.919 1.00 108.10 ? 260 ARG A CZ  1 ? 
ATOM   1693 N NH1 . ARG A 1 228 ? 2.329   -14.546 37.283 1.00 106.80 ? 260 ARG A NH1 1 ? 
ATOM   1694 N NH2 . ARG A 1 228 ? 1.489   -15.363 39.243 1.00 103.87 ? 260 ARG A NH2 1 ? 
ATOM   1695 N N   . TYR A 1 229 ? 0.081   -11.626 34.047 1.00 72.47  ? 261 TYR A N   1 ? 
ATOM   1696 C CA  . TYR A 1 229 ? 1.056   -10.609 34.405 1.00 70.32  ? 261 TYR A CA  1 ? 
ATOM   1697 C C   . TYR A 1 229 ? 2.146   -11.299 35.217 1.00 72.02  ? 261 TYR A C   1 ? 
ATOM   1698 O O   . TYR A 1 229 ? 1.852   -11.934 36.225 1.00 76.43  ? 261 TYR A O   1 ? 
ATOM   1699 C CB  . TYR A 1 229 ? 0.430   -9.460  35.208 1.00 73.96  ? 261 TYR A CB  1 ? 
ATOM   1700 C CG  . TYR A 1 229 ? 1.449   -8.450  35.726 1.00 76.28  ? 261 TYR A CG  1 ? 
ATOM   1701 C CD1 . TYR A 1 229 ? 1.886   -7.408  34.916 1.00 76.04  ? 261 TYR A CD1 1 ? 
ATOM   1702 C CD2 . TYR A 1 229 ? 1.995   -8.548  37.002 1.00 74.43  ? 261 TYR A CD2 1 ? 
ATOM   1703 C CE1 . TYR A 1 229 ? 2.822   -6.490  35.356 1.00 78.12  ? 261 TYR A CE1 1 ? 
ATOM   1704 C CE2 . TYR A 1 229 ? 2.939   -7.639  37.454 1.00 76.67  ? 261 TYR A CE2 1 ? 
ATOM   1705 C CZ  . TYR A 1 229 ? 3.350   -6.605  36.629 1.00 81.70  ? 261 TYR A CZ  1 ? 
ATOM   1706 O OH  . TYR A 1 229 ? 4.272   -5.683  37.036 1.00 74.78  ? 261 TYR A OH  1 ? 
ATOM   1707 N N   . PRO A 1 230 ? 3.433   -11.235 34.818 1.00 75.85  ? 262 PRO A N   1 ? 
ATOM   1708 C CA  . PRO A 1 230 ? 4.391   -12.230 35.295 1.00 78.76  ? 262 PRO A CA  1 ? 
ATOM   1709 C C   . PRO A 1 230 ? 5.247   -11.889 36.511 1.00 82.58  ? 262 PRO A C   1 ? 
ATOM   1710 O O   . PRO A 1 230 ? 6.299   -12.495 36.693 1.00 89.31  ? 262 PRO A O   1 ? 
ATOM   1711 C CB  . PRO A 1 230 ? 5.209   -12.367 34.001 1.00 72.69  ? 262 PRO A CB  1 ? 
ATOM   1712 C CG  . PRO A 1 230 ? 5.315   -10.952 33.477 1.00 76.40  ? 262 PRO A CG  1 ? 
ATOM   1713 C CD  . PRO A 1 230 ? 4.026   -10.259 33.891 1.00 74.53  ? 262 PRO A CD  1 ? 
ATOM   1714 N N   . ILE A 1 231 ? 4.792   -10.944 37.345 1.00 91.74  ? 263 ILE A N   1 ? 
ATOM   1715 C CA  . ILE A 1 231 ? 5.493   -10.630 38.585 1.00 100.22 ? 263 ILE A CA  1 ? 
ATOM   1716 C C   . ILE A 1 231 ? 4.487   -10.661 39.734 1.00 102.67 ? 263 ILE A C   1 ? 
ATOM   1717 O O   . ILE A 1 231 ? 3.618   -9.794  39.804 1.00 102.14 ? 263 ILE A O   1 ? 
ATOM   1718 C CB  . ILE A 1 231 ? 6.220   -9.272  38.519 1.00 99.28  ? 263 ILE A CB  1 ? 
ATOM   1719 C CG1 . ILE A 1 231 ? 6.756   -8.966  37.116 1.00 101.36 ? 263 ILE A CG1 1 ? 
ATOM   1720 C CG2 . ILE A 1 231 ? 7.311   -9.217  39.588 1.00 100.23 ? 263 ILE A CG2 1 ? 
ATOM   1721 C CD1 . ILE A 1 231 ? 7.861   -7.926  37.068 1.00 100.77 ? 263 ILE A CD1 1 ? 
ATOM   1722 N N   . PRO A 1 232 ? 4.559   -11.632 40.677 1.00 107.19 ? 264 PRO A N   1 ? 
ATOM   1723 C CA  . PRO A 1 232 ? 5.690   -12.559 40.806 1.00 106.54 ? 264 PRO A CA  1 ? 
ATOM   1724 C C   . PRO A 1 232 ? 5.636   -13.756 39.858 1.00 99.86  ? 264 PRO A C   1 ? 
ATOM   1725 O O   . PRO A 1 232 ? 4.579   -14.056 39.311 1.00 93.16  ? 264 PRO A O   1 ? 
ATOM   1726 C CB  . PRO A 1 232 ? 5.513   -12.997 42.263 1.00 112.46 ? 264 PRO A CB  1 ? 
ATOM   1727 C CG  . PRO A 1 232 ? 4.010   -13.144 42.393 1.00 114.92 ? 264 PRO A CG  1 ? 
ATOM   1728 C CD  . PRO A 1 232 ? 3.483   -11.930 41.638 1.00 113.68 ? 264 PRO A CD  1 ? 
ATOM   1729 N N   . PRO A 1 233 ? 6.758   -14.484 39.634 1.00 104.09 ? 265 PRO A N   1 ? 
ATOM   1730 C CA  . PRO A 1 233 ? 6.769   -15.596 38.683 1.00 104.96 ? 265 PRO A CA  1 ? 
ATOM   1731 C C   . PRO A 1 233 ? 5.780   -16.671 39.121 1.00 110.49 ? 265 PRO A C   1 ? 
ATOM   1732 O O   . PRO A 1 233 ? 5.609   -16.898 40.315 1.00 108.67 ? 265 PRO A O   1 ? 
ATOM   1733 C CB  . PRO A 1 233 ? 8.224   -16.111 38.676 1.00 98.63  ? 265 PRO A CB  1 ? 
ATOM   1734 C CG  . PRO A 1 233 ? 9.029   -14.988 39.298 1.00 97.29  ? 265 PRO A CG  1 ? 
ATOM   1735 C CD  . PRO A 1 233 ? 8.077   -14.271 40.251 1.00 105.70 ? 265 PRO A CD  1 ? 
ATOM   1736 N N   . PRO A 1 234 ? 5.102   -17.360 38.175 1.00 124.95 ? 266 PRO A N   1 ? 
ATOM   1737 C CA  . PRO A 1 234 ? 4.197   -18.457 38.526 1.00 132.93 ? 266 PRO A CA  1 ? 
ATOM   1738 C C   . PRO A 1 234 ? 4.781   -19.467 39.514 1.00 146.33 ? 266 PRO A C   1 ? 
ATOM   1739 O O   . PRO A 1 234 ? 4.029   -20.092 40.259 1.00 143.85 ? 266 PRO A O   1 ? 
ATOM   1740 C CB  . PRO A 1 234 ? 3.908   -19.089 37.157 1.00 131.40 ? 266 PRO A CB  1 ? 
ATOM   1741 C CG  . PRO A 1 234 ? 4.015   -17.936 36.188 1.00 129.75 ? 266 PRO A CG  1 ? 
ATOM   1742 C CD  . PRO A 1 234 ? 5.159   -17.102 36.726 1.00 128.27 ? 266 PRO A CD  1 ? 
ATOM   1743 N N   . ASP A 1 235 ? 6.117   -19.612 39.501 1.00 163.59 ? 267 ASP A N   1 ? 
ATOM   1744 C CA  . ASP A 1 235 ? 6.859   -20.455 40.432 1.00 174.42 ? 267 ASP A CA  1 ? 
ATOM   1745 C C   . ASP A 1 235 ? 6.109   -21.764 40.671 1.00 178.71 ? 267 ASP A C   1 ? 
ATOM   1746 O O   . ASP A 1 235 ? 6.422   -22.776 40.046 1.00 174.46 ? 267 ASP A O   1 ? 
ATOM   1747 C CB  . ASP A 1 235 ? 7.197   -19.733 41.733 1.00 174.99 ? 267 ASP A CB  1 ? 
ATOM   1748 C CG  . ASP A 1 235 ? 8.544   -19.022 41.784 1.00 171.53 ? 267 ASP A CG  1 ? 
ATOM   1749 O OD1 . ASP A 1 235 ? 9.558   -19.657 41.424 1.00 156.53 ? 267 ASP A OD1 1 ? 
ATOM   1750 O OD2 . ASP A 1 235 ? 8.575   -17.851 42.222 1.00 176.03 ? 267 ASP A OD2 1 ? 
ATOM   1751 N N   . ALA A 1 236 ? 5.130   -21.722 41.586 1.00 184.33 ? 268 ALA A N   1 ? 
ATOM   1752 C CA  . ALA A 1 236 ? 4.311   -22.873 41.931 1.00 188.18 ? 268 ALA A CA  1 ? 
ATOM   1753 C C   . ALA A 1 236 ? 3.737   -23.498 40.663 1.00 192.65 ? 268 ALA A C   1 ? 
ATOM   1754 O O   . ALA A 1 236 ? 2.664   -23.106 40.210 1.00 204.23 ? 268 ALA A O   1 ? 
ATOM   1755 C CB  . ALA A 1 236 ? 3.216   -22.450 42.889 1.00 185.77 ? 268 ALA A CB  1 ? 
ATOM   1756 N N   . LYS A 1 237 ? 4.470   -24.479 40.117 1.00 188.95 ? 269 LYS A N   1 ? 
ATOM   1757 C CA  . LYS A 1 237 ? 4.182   -25.094 38.830 1.00 182.85 ? 269 LYS A CA  1 ? 
ATOM   1758 C C   . LYS A 1 237 ? 3.515   -24.068 37.911 1.00 186.12 ? 269 LYS A C   1 ? 
ATOM   1759 O O   . LYS A 1 237 ? 4.209   -23.284 37.268 1.00 177.41 ? 269 LYS A O   1 ? 
ATOM   1760 C CB  . LYS A 1 237 ? 3.362   -26.387 38.961 1.00 180.83 ? 269 LYS A CB  1 ? 
ATOM   1761 C CG  . LYS A 1 237 ? 3.405   -27.136 40.290 1.00 181.92 ? 269 LYS A CG  1 ? 
ATOM   1762 C CD  . LYS A 1 237 ? 2.396   -26.726 41.362 1.00 187.68 ? 269 LYS A CD  1 ? 
ATOM   1763 C CE  . LYS A 1 237 ? 0.964   -26.553 40.925 1.00 189.81 ? 269 LYS A CE  1 ? 
ATOM   1764 N NZ  . LYS A 1 237 ? 0.555   -25.146 40.849 1.00 190.50 ? 269 LYS A NZ  1 ? 
ATOM   1765 N N   . GLU A 1 238 ? 2.172   -24.064 37.885 1.00 183.10 ? 270 GLU A N   1 ? 
ATOM   1766 C CA  . GLU A 1 238 ? 1.364   -23.256 36.981 1.00 171.63 ? 270 GLU A CA  1 ? 
ATOM   1767 C C   . GLU A 1 238 ? 1.831   -23.463 35.542 1.00 161.08 ? 270 GLU A C   1 ? 
ATOM   1768 O O   . GLU A 1 238 ? 1.026   -23.817 34.687 1.00 161.35 ? 270 GLU A O   1 ? 
ATOM   1769 C CB  . GLU A 1 238 ? 1.302   -21.797 37.441 1.00 173.69 ? 270 GLU A CB  1 ? 
ATOM   1770 C CG  . GLU A 1 238 ? 0.240   -21.570 38.515 1.00 174.89 ? 270 GLU A CG  1 ? 
ATOM   1771 C CD  . GLU A 1 238 ? 0.271   -20.219 39.207 1.00 176.58 ? 270 GLU A CD  1 ? 
ATOM   1772 O OE1 . GLU A 1 238 ? -0.175  -19.224 38.599 1.00 183.82 ? 270 GLU A OE1 1 ? 
ATOM   1773 O OE2 . GLU A 1 238 ? 0.751   -20.164 40.358 1.00 174.67 ? 270 GLU A OE2 1 ? 
ATOM   1774 N N   . LEU A 1 239 ? 3.126   -23.242 35.291 1.00 153.47 ? 271 LEU A N   1 ? 
ATOM   1775 C CA  . LEU A 1 239 ? 3.750   -23.563 34.016 1.00 158.25 ? 271 LEU A CA  1 ? 
ATOM   1776 C C   . LEU A 1 239 ? 3.440   -25.007 33.615 1.00 152.57 ? 271 LEU A C   1 ? 
ATOM   1777 O O   . LEU A 1 239 ? 3.178   -25.280 32.444 1.00 135.02 ? 271 LEU A O   1 ? 
ATOM   1778 C CB  . LEU A 1 239 ? 5.261   -23.323 34.081 1.00 161.25 ? 271 LEU A CB  1 ? 
ATOM   1779 C CG  . LEU A 1 239 ? 5.750   -21.874 34.223 1.00 158.79 ? 271 LEU A CG  1 ? 
ATOM   1780 C CD1 . LEU A 1 239 ? 4.749   -20.835 33.736 1.00 163.31 ? 271 LEU A CD1 1 ? 
ATOM   1781 C CD2 . LEU A 1 239 ? 6.186   -21.559 35.644 1.00 159.25 ? 271 LEU A CD2 1 ? 
ATOM   1782 N N   . GLU A 1 240 ? 3.489   -25.929 34.586 1.00 157.86 ? 272 GLU A N   1 ? 
ATOM   1783 C CA  . GLU A 1 240 ? 3.180   -27.333 34.346 1.00 157.05 ? 272 GLU A CA  1 ? 
ATOM   1784 C C   . GLU A 1 240 ? 1.707   -27.472 33.954 1.00 149.16 ? 272 GLU A C   1 ? 
ATOM   1785 O O   . GLU A 1 240 ? 1.382   -28.235 33.044 1.00 143.05 ? 272 GLU A O   1 ? 
ATOM   1786 C CB  . GLU A 1 240 ? 3.617   -28.177 35.549 1.00 164.35 ? 272 GLU A CB  1 ? 
ATOM   1787 C CG  . GLU A 1 240 ? 2.889   -29.510 35.708 1.00 173.37 ? 272 GLU A CG  1 ? 
ATOM   1788 C CD  . GLU A 1 240 ? 1.801   -29.532 36.768 1.00 184.02 ? 272 GLU A CD  1 ? 
ATOM   1789 O OE1 . GLU A 1 240 ? 1.721   -30.557 37.479 1.00 180.14 ? 272 GLU A OE1 1 ? 
ATOM   1790 O OE2 . GLU A 1 240 ? 1.056   -28.538 36.902 1.00 199.02 ? 272 GLU A OE2 1 ? 
ATOM   1791 N N   . LEU A 1 241 ? 0.835   -26.718 34.641 1.00 138.70 ? 273 LEU A N   1 ? 
ATOM   1792 C CA  . LEU A 1 241 ? -0.590  -26.668 34.340 1.00 132.41 ? 273 LEU A CA  1 ? 
ATOM   1793 C C   . LEU A 1 241 ? -0.819  -25.991 32.987 1.00 131.72 ? 273 LEU A C   1 ? 
ATOM   1794 O O   . LEU A 1 241 ? -1.425  -26.586 32.097 1.00 130.19 ? 273 LEU A O   1 ? 
ATOM   1795 C CB  . LEU A 1 241 ? -1.306  -25.951 35.491 1.00 136.73 ? 273 LEU A CB  1 ? 
ATOM   1796 C CG  . LEU A 1 241 ? -2.637  -25.251 35.184 1.00 143.15 ? 273 LEU A CG  1 ? 
ATOM   1797 C CD1 . LEU A 1 241 ? -3.828  -26.198 35.132 1.00 146.14 ? 273 LEU A CD1 1 ? 
ATOM   1798 C CD2 . LEU A 1 241 ? -2.879  -24.150 36.210 1.00 139.19 ? 273 LEU A CD2 1 ? 
ATOM   1799 N N   . MET A 1 242 ? -0.316  -24.753 32.853 1.00 130.79 ? 274 MET A N   1 ? 
ATOM   1800 C CA  . MET A 1 242 ? -0.519  -23.895 31.690 1.00 118.56 ? 274 MET A CA  1 ? 
ATOM   1801 C C   . MET A 1 242 ? -0.126  -24.618 30.397 1.00 112.49 ? 274 MET A C   1 ? 
ATOM   1802 O O   . MET A 1 242 ? -0.945  -24.745 29.482 1.00 102.76 ? 274 MET A O   1 ? 
ATOM   1803 C CB  . MET A 1 242 ? 0.240   -22.569 31.876 1.00 122.54 ? 274 MET A CB  1 ? 
ATOM   1804 C CG  . MET A 1 242 ? -0.501  -21.558 32.765 1.00 127.02 ? 274 MET A CG  1 ? 
ATOM   1805 S SD  . MET A 1 242 ? 0.513   -20.516 33.840 1.00 130.14 ? 274 MET A SD  1 ? 
ATOM   1806 C CE  . MET A 1 242 ? 0.806   -18.950 33.004 1.00 129.30 ? 274 MET A CE  1 ? 
ATOM   1807 N N   . PHE A 1 243 ? 1.113   -25.123 30.328 1.00 104.09 ? 275 PHE A N   1 ? 
ATOM   1808 C CA  . PHE A 1 243 ? 1.640   -25.674 29.087 1.00 112.45 ? 275 PHE A CA  1 ? 
ATOM   1809 C C   . PHE A 1 243 ? 1.924   -27.180 29.242 1.00 122.35 ? 275 PHE A C   1 ? 
ATOM   1810 O O   . PHE A 1 243 ? 1.276   -27.895 30.044 1.00 123.06 ? 275 PHE A O   1 ? 
ATOM   1811 C CB  . PHE A 1 243 ? 2.921   -24.939 28.679 1.00 109.04 ? 275 PHE A CB  1 ? 
ATOM   1812 C CG  . PHE A 1 243 ? 2.942   -23.424 28.861 1.00 103.63 ? 275 PHE A CG  1 ? 
ATOM   1813 C CD1 . PHE A 1 243 ? 3.206   -22.854 30.105 1.00 100.43 ? 275 PHE A CD1 1 ? 
ATOM   1814 C CD2 . PHE A 1 243 ? 2.756   -22.570 27.778 1.00 92.67  ? 275 PHE A CD2 1 ? 
ATOM   1815 C CE1 . PHE A 1 243 ? 3.249   -21.476 30.261 1.00 97.81  ? 275 PHE A CE1 1 ? 
ATOM   1816 C CE2 . PHE A 1 243 ? 2.809   -21.192 27.940 1.00 90.89  ? 275 PHE A CE2 1 ? 
ATOM   1817 C CZ  . PHE A 1 243 ? 3.054   -20.648 29.179 1.00 89.20  ? 275 PHE A CZ  1 ? 
ATOM   1818 N N   . ALA A 1 277 ? 0.383   -6.429  46.691 1.00 158.28 ? 309 ALA A N   1 ? 
ATOM   1819 C CA  . ALA A 1 277 ? 0.254   -4.950  46.737 1.00 155.24 ? 309 ALA A CA  1 ? 
ATOM   1820 C C   . ALA A 1 277 ? 1.273   -4.315  45.795 1.00 143.53 ? 309 ALA A C   1 ? 
ATOM   1821 O O   . ALA A 1 277 ? 2.147   -5.004  45.273 1.00 141.63 ? 309 ALA A O   1 ? 
ATOM   1822 C CB  . ALA A 1 277 ? 0.429   -4.457  48.158 1.00 160.61 ? 309 ALA A CB  1 ? 
ATOM   1823 N N   . ILE A 1 278 ? 1.154   -2.999  45.591 1.00 138.67 ? 310 ILE A N   1 ? 
ATOM   1824 C CA  . ILE A 1 278 ? 2.035   -2.285  44.677 1.00 147.11 ? 310 ILE A CA  1 ? 
ATOM   1825 C C   . ILE A 1 278 ? 3.404   -2.086  45.333 1.00 154.08 ? 310 ILE A C   1 ? 
ATOM   1826 O O   . ILE A 1 278 ? 4.425   -2.323  44.692 1.00 155.52 ? 310 ILE A O   1 ? 
ATOM   1827 C CB  . ILE A 1 278 ? 1.398   -0.961  44.201 1.00 151.09 ? 310 ILE A CB  1 ? 
ATOM   1828 C CG1 . ILE A 1 278 ? 2.118   -0.378  42.972 1.00 148.24 ? 310 ILE A CG1 1 ? 
ATOM   1829 C CG2 . ILE A 1 278 ? 1.299   0.067   45.331 1.00 152.12 ? 310 ILE A CG2 1 ? 
ATOM   1830 C CD1 . ILE A 1 278 ? 1.910   -1.161  41.687 1.00 140.37 ? 310 ILE A CD1 1 ? 
ATOM   1831 N N   . PHE A 1 279 ? 3.420   -1.679  46.612 1.00 156.00 ? 311 PHE A N   1 ? 
ATOM   1832 C CA  . PHE A 1 279 ? 4.650   -1.325  47.312 1.00 139.29 ? 311 PHE A CA  1 ? 
ATOM   1833 C C   . PHE A 1 279 ? 5.583   -2.538  47.351 1.00 118.08 ? 311 PHE A C   1 ? 
ATOM   1834 O O   . PHE A 1 279 ? 6.774   -2.412  47.080 1.00 101.35 ? 311 PHE A O   1 ? 
ATOM   1835 C CB  . PHE A 1 279 ? 4.333   -0.747  48.700 1.00 140.77 ? 311 PHE A CB  1 ? 
ATOM   1836 C CG  . PHE A 1 279 ? 3.783   -1.721  49.738 1.00 146.57 ? 311 PHE A CG  1 ? 
ATOM   1837 C CD1 . PHE A 1 279 ? 2.422   -2.005  49.809 1.00 145.05 ? 311 PHE A CD1 1 ? 
ATOM   1838 C CD2 . PHE A 1 279 ? 4.629   -2.335  50.659 1.00 153.77 ? 311 PHE A CD2 1 ? 
ATOM   1839 C CE1 . PHE A 1 279 ? 1.930   -2.891  50.758 1.00 144.20 ? 311 PHE A CE1 1 ? 
ATOM   1840 C CE2 . PHE A 1 279 ? 4.131   -3.219  51.608 1.00 148.44 ? 311 PHE A CE2 1 ? 
ATOM   1841 C CZ  . PHE A 1 279 ? 2.784   -3.493  51.656 1.00 146.74 ? 311 PHE A CZ  1 ? 
ATOM   1842 N N   . GLU A 1 280 ? 5.024   -3.712  47.665 1.00 118.04 ? 312 GLU A N   1 ? 
ATOM   1843 C CA  . GLU A 1 280 ? 5.777   -4.956  47.743 1.00 115.57 ? 312 GLU A CA  1 ? 
ATOM   1844 C C   . GLU A 1 280 ? 6.322   -5.331  46.363 1.00 117.75 ? 312 GLU A C   1 ? 
ATOM   1845 O O   . GLU A 1 280 ? 7.459   -5.789  46.249 1.00 119.34 ? 312 GLU A O   1 ? 
ATOM   1846 C CB  . GLU A 1 280 ? 4.867   -6.026  48.352 1.00 115.35 ? 312 GLU A CB  1 ? 
ATOM   1847 C CG  . GLU A 1 280 ? 5.463   -7.432  48.367 1.00 122.53 ? 312 GLU A CG  1 ? 
ATOM   1848 C CD  . GLU A 1 280 ? 6.902   -7.523  48.846 1.00 133.66 ? 312 GLU A CD  1 ? 
ATOM   1849 O OE1 . GLU A 1 280 ? 7.175   -7.151  50.008 1.00 137.65 ? 312 GLU A OE1 1 ? 
ATOM   1850 O OE2 . GLU A 1 280 ? 7.755   -7.964  48.044 1.00 136.84 ? 312 GLU A OE2 1 ? 
ATOM   1851 N N   . LEU A 1 281 ? 5.503   -5.112  45.323 1.00 110.39 ? 313 LEU A N   1 ? 
ATOM   1852 C CA  . LEU A 1 281 ? 5.834   -5.453  43.946 1.00 93.76  ? 313 LEU A CA  1 ? 
ATOM   1853 C C   . LEU A 1 281 ? 6.993   -4.610  43.410 1.00 93.55  ? 313 LEU A C   1 ? 
ATOM   1854 O O   . LEU A 1 281 ? 7.755   -5.086  42.570 1.00 90.41  ? 313 LEU A O   1 ? 
ATOM   1855 C CB  . LEU A 1 281 ? 4.576   -5.249  43.108 1.00 91.96  ? 313 LEU A CB  1 ? 
ATOM   1856 C CG  . LEU A 1 281 ? 4.721   -5.449  41.596 1.00 98.77  ? 313 LEU A CG  1 ? 
ATOM   1857 C CD1 . LEU A 1 281 ? 4.887   -6.918  41.247 1.00 97.94  ? 313 LEU A CD1 1 ? 
ATOM   1858 C CD2 . LEU A 1 281 ? 3.530   -4.861  40.866 1.00 102.34 ? 313 LEU A CD2 1 ? 
ATOM   1859 N N   . LEU A 1 282 ? 7.109   -3.356  43.866 1.00 91.52  ? 314 LEU A N   1 ? 
ATOM   1860 C CA  . LEU A 1 282 ? 8.111   -2.441  43.342 1.00 104.07 ? 314 LEU A CA  1 ? 
ATOM   1861 C C   . LEU A 1 282 ? 9.503   -2.871  43.801 1.00 106.26 ? 314 LEU A C   1 ? 
ATOM   1862 O O   . LEU A 1 282 ? 10.442  -2.876  43.007 1.00 106.54 ? 314 LEU A O   1 ? 
ATOM   1863 C CB  . LEU A 1 282 ? 7.818   -0.999  43.756 1.00 112.16 ? 314 LEU A CB  1 ? 
ATOM   1864 C CG  . LEU A 1 282 ? 6.452   -0.430  43.354 1.00 116.00 ? 314 LEU A CG  1 ? 
ATOM   1865 C CD1 . LEU A 1 282 ? 6.452   1.082   43.542 1.00 120.26 ? 314 LEU A CD1 1 ? 
ATOM   1866 C CD2 . LEU A 1 282 ? 6.027   -0.797  41.936 1.00 108.99 ? 314 LEU A CD2 1 ? 
ATOM   1867 N N   . ASP A 1 283 ? 9.629   -3.222  45.086 1.00 109.14 ? 315 ASP A N   1 ? 
ATOM   1868 C CA  . ASP A 1 283 ? 10.898  -3.683  45.627 1.00 112.08 ? 315 ASP A CA  1 ? 
ATOM   1869 C C   . ASP A 1 283 ? 11.263  -5.007  44.960 1.00 106.60 ? 315 ASP A C   1 ? 
ATOM   1870 O O   . ASP A 1 283 ? 12.441  -5.299  44.765 1.00 104.11 ? 315 ASP A O   1 ? 
ATOM   1871 C CB  . ASP A 1 283 ? 10.868  -3.775  47.146 1.00 119.57 ? 315 ASP A CB  1 ? 
ATOM   1872 C CG  . ASP A 1 283 ? 10.418  -2.516  47.876 1.00 122.26 ? 315 ASP A CG  1 ? 
ATOM   1873 O OD1 . ASP A 1 283 ? 10.941  -1.426  47.552 1.00 118.99 ? 315 ASP A OD1 1 ? 
ATOM   1874 O OD2 . ASP A 1 283 ? 9.552   -2.636  48.768 1.00 116.72 ? 315 ASP A OD2 1 ? 
ATOM   1875 N N   . TYR A 1 284 ? 10.238  -5.790  44.595 1.00 103.81 ? 316 TYR A N   1 ? 
ATOM   1876 C CA  . TYR A 1 284 ? 10.435  -7.047  43.890 1.00 99.97  ? 316 TYR A CA  1 ? 
ATOM   1877 C C   . TYR A 1 284 ? 11.050  -6.764  42.518 1.00 94.03  ? 316 TYR A C   1 ? 
ATOM   1878 O O   . TYR A 1 284 ? 12.013  -7.424  42.132 1.00 89.64  ? 316 TYR A O   1 ? 
ATOM   1879 C CB  . TYR A 1 284 ? 9.120   -7.832  43.809 1.00 98.47  ? 316 TYR A CB  1 ? 
ATOM   1880 C CG  . TYR A 1 284 ? 9.283   -9.320  43.520 1.00 100.19 ? 316 TYR A CG  1 ? 
ATOM   1881 C CD1 . TYR A 1 284 ? 9.643   -9.770  42.253 1.00 104.83 ? 316 TYR A CD1 1 ? 
ATOM   1882 C CD2 . TYR A 1 284 ? 9.055   -10.277 44.502 1.00 98.81  ? 316 TYR A CD2 1 ? 
ATOM   1883 C CE1 . TYR A 1 284 ? 9.791   -11.120 41.975 1.00 100.91 ? 316 TYR A CE1 1 ? 
ATOM   1884 C CE2 . TYR A 1 284 ? 9.186   -11.631 44.234 1.00 105.88 ? 316 TYR A CE2 1 ? 
ATOM   1885 C CZ  . TYR A 1 284 ? 9.557   -12.054 42.968 1.00 107.62 ? 316 TYR A CZ  1 ? 
ATOM   1886 O OH  . TYR A 1 284 ? 9.703   -13.383 42.687 1.00 110.93 ? 316 TYR A OH  1 ? 
ATOM   1887 N N   . ILE A 1 285 ? 10.511  -5.769  41.799 1.00 80.30  ? 317 ILE A N   1 ? 
ATOM   1888 C CA  . ILE A 1 285 ? 10.994  -5.438  40.467 1.00 88.66  ? 317 ILE A CA  1 ? 
ATOM   1889 C C   . ILE A 1 285 ? 12.433  -4.922  40.545 1.00 98.57  ? 317 ILE A C   1 ? 
ATOM   1890 O O   . ILE A 1 285 ? 13.224  -5.178  39.635 1.00 98.40  ? 317 ILE A O   1 ? 
ATOM   1891 C CB  . ILE A 1 285 ? 10.057  -4.436  39.759 1.00 87.79  ? 317 ILE A CB  1 ? 
ATOM   1892 C CG1 . ILE A 1 285 ? 8.715   -5.076  39.387 1.00 84.00  ? 317 ILE A CG1 1 ? 
ATOM   1893 C CG2 . ILE A 1 285 ? 10.733  -3.822  38.530 1.00 88.34  ? 317 ILE A CG2 1 ? 
ATOM   1894 C CD1 . ILE A 1 285 ? 7.596   -4.086  39.105 1.00 84.72  ? 317 ILE A CD1 1 ? 
ATOM   1895 N N   . VAL A 1 286 ? 12.760  -4.193  41.624 1.00 98.27  ? 318 VAL A N   1 ? 
ATOM   1896 C CA  . VAL A 1 286 ? 14.081  -3.601  41.789 1.00 100.23 ? 318 VAL A CA  1 ? 
ATOM   1897 C C   . VAL A 1 286 ? 15.076  -4.660  42.269 1.00 99.32  ? 318 VAL A C   1 ? 
ATOM   1898 O O   . VAL A 1 286 ? 16.177  -4.749  41.731 1.00 99.95  ? 318 VAL A O   1 ? 
ATOM   1899 C CB  . VAL A 1 286 ? 14.058  -2.394  42.747 1.00 105.03 ? 318 VAL A CB  1 ? 
ATOM   1900 C CG1 . VAL A 1 286 ? 15.460  -1.861  43.042 1.00 102.38 ? 318 VAL A CG1 1 ? 
ATOM   1901 C CG2 . VAL A 1 286 ? 13.167  -1.276  42.219 1.00 107.89 ? 318 VAL A CG2 1 ? 
ATOM   1902 N N   . ASN A 1 287 ? 14.693  -5.453  43.280 1.00 94.79  ? 319 ASN A N   1 ? 
ATOM   1903 C CA  . ASN A 1 287 ? 15.619  -6.357  43.948 1.00 97.72  ? 319 ASN A CA  1 ? 
ATOM   1904 C C   . ASN A 1 287 ? 15.750  -7.678  43.196 1.00 99.31  ? 319 ASN A C   1 ? 
ATOM   1905 O O   . ASN A 1 287 ? 16.859  -8.164  42.993 1.00 103.92 ? 319 ASN A O   1 ? 
ATOM   1906 C CB  . ASN A 1 287 ? 15.198  -6.652  45.382 1.00 98.94  ? 319 ASN A CB  1 ? 
ATOM   1907 C CG  . ASN A 1 287 ? 15.042  -5.388  46.191 1.00 103.10 ? 319 ASN A CG  1 ? 
ATOM   1908 O OD1 . ASN A 1 287 ? 15.774  -4.419  45.967 1.00 98.29  ? 319 ASN A OD1 1 ? 
ATOM   1909 N ND2 . ASN A 1 287 ? 14.078  -5.358  47.099 1.00 113.52 ? 319 ASN A ND2 1 ? 
ATOM   1910 N N   . GLU A 1 288 ? 14.611  -8.264  42.809 1.00 102.41 ? 320 GLU A N   1 ? 
ATOM   1911 C CA  . GLU A 1 288 ? 14.584  -9.628  42.305 1.00 98.33  ? 320 GLU A CA  1 ? 
ATOM   1912 C C   . GLU A 1 288 ? 15.063  -9.653  40.854 1.00 100.03 ? 320 GLU A C   1 ? 
ATOM   1913 O O   . GLU A 1 288 ? 15.258  -8.604  40.246 1.00 101.51 ? 320 GLU A O   1 ? 
ATOM   1914 C CB  . GLU A 1 288 ? 13.185  -10.222 42.469 1.00 99.37  ? 320 GLU A CB  1 ? 
ATOM   1915 C CG  . GLU A 1 288 ? 12.687  -10.234 43.912 1.00 103.42 ? 320 GLU A CG  1 ? 
ATOM   1916 C CD  . GLU A 1 288 ? 13.617  -10.919 44.899 1.00 104.79 ? 320 GLU A CD  1 ? 
ATOM   1917 O OE1 . GLU A 1 288 ? 14.234  -11.930 44.492 1.00 90.17  ? 320 GLU A OE1 1 ? 
ATOM   1918 O OE2 . GLU A 1 288 ? 13.708  -10.456 46.065 1.00 102.44 ? 320 GLU A OE2 1 ? 
ATOM   1919 N N   . PRO A 1 289 ? 15.328  -10.846 40.269 1.00 97.79  ? 321 PRO A N   1 ? 
ATOM   1920 C CA  . PRO A 1 289 ? 15.705  -10.939 38.856 1.00 92.36  ? 321 PRO A CA  1 ? 
ATOM   1921 C C   . PRO A 1 289 ? 14.519  -10.730 37.912 1.00 89.67  ? 321 PRO A C   1 ? 
ATOM   1922 O O   . PRO A 1 289 ? 13.368  -10.979 38.283 1.00 86.39  ? 321 PRO A O   1 ? 
ATOM   1923 C CB  . PRO A 1 289 ? 16.317  -12.359 38.735 1.00 90.95  ? 321 PRO A CB  1 ? 
ATOM   1924 C CG  . PRO A 1 289 ? 16.449  -12.861 40.164 1.00 92.04  ? 321 PRO A CG  1 ? 
ATOM   1925 C CD  . PRO A 1 289 ? 15.352  -12.157 40.940 1.00 91.86  ? 321 PRO A CD  1 ? 
ATOM   1926 N N   . PRO A 1 290 ? 14.766  -10.302 36.649 1.00 85.54  ? 322 PRO A N   1 ? 
ATOM   1927 C CA  . PRO A 1 290 ? 13.679  -10.018 35.712 1.00 80.80  ? 322 PRO A CA  1 ? 
ATOM   1928 C C   . PRO A 1 290 ? 12.897  -11.293 35.422 1.00 75.91  ? 322 PRO A C   1 ? 
ATOM   1929 O O   . PRO A 1 290 ? 13.410  -12.391 35.612 1.00 71.71  ? 322 PRO A O   1 ? 
ATOM   1930 C CB  . PRO A 1 290 ? 14.368  -9.449  34.451 1.00 80.75  ? 322 PRO A CB  1 ? 
ATOM   1931 C CG  . PRO A 1 290 ? 15.826  -9.856  34.572 1.00 75.78  ? 322 PRO A CG  1 ? 
ATOM   1932 C CD  . PRO A 1 290 ? 16.096  -10.096 36.052 1.00 82.09  ? 322 PRO A CD  1 ? 
ATOM   1933 N N   . PRO A 1 291 ? 11.629  -11.205 34.966 1.00 77.13  ? 323 PRO A N   1 ? 
ATOM   1934 C CA  . PRO A 1 291 ? 10.936  -12.383 34.447 1.00 71.16  ? 323 PRO A CA  1 ? 
ATOM   1935 C C   . PRO A 1 291 ? 11.592  -12.945 33.189 1.00 73.18  ? 323 PRO A C   1 ? 
ATOM   1936 O O   . PRO A 1 291 ? 12.447  -12.316 32.562 1.00 72.95  ? 323 PRO A O   1 ? 
ATOM   1937 C CB  . PRO A 1 291 ? 9.513   -11.890 34.185 1.00 76.63  ? 323 PRO A CB  1 ? 
ATOM   1938 C CG  . PRO A 1 291 ? 9.673   -10.405 34.004 1.00 86.18  ? 323 PRO A CG  1 ? 
ATOM   1939 C CD  . PRO A 1 291 ? 10.789  -10.000 34.958 1.00 86.34  ? 323 PRO A CD  1 ? 
ATOM   1940 N N   . LYS A 1 292 ? 11.187  -14.168 32.853 1.00 74.47  ? 324 LYS A N   1 ? 
ATOM   1941 C CA  . LYS A 1 292 ? 11.573  -14.795 31.608 1.00 77.25  ? 324 LYS A CA  1 ? 
ATOM   1942 C C   . LYS A 1 292 ? 10.425  -15.685 31.147 1.00 75.75  ? 324 LYS A C   1 ? 
ATOM   1943 O O   . LYS A 1 292 ? 9.612   -16.151 31.941 1.00 75.43  ? 324 LYS A O   1 ? 
ATOM   1944 C CB  . LYS A 1 292 ? 12.854  -15.613 31.793 1.00 84.15  ? 324 LYS A CB  1 ? 
ATOM   1945 C CG  . LYS A 1 292 ? 12.731  -16.779 32.775 1.00 99.53  ? 324 LYS A CG  1 ? 
ATOM   1946 C CD  . LYS A 1 292 ? 14.015  -17.547 33.079 1.00 114.25 ? 324 LYS A CD  1 ? 
ATOM   1947 C CE  . LYS A 1 292 ? 15.139  -16.705 33.608 1.00 123.83 ? 324 LYS A CE  1 ? 
ATOM   1948 N NZ  . LYS A 1 292 ? 14.781  -15.971 34.826 1.00 127.56 ? 324 LYS A NZ  1 ? 
ATOM   1949 N N   . LEU A 1 293 ? 10.387  -15.922 29.843 1.00 69.60  ? 325 LEU A N   1 ? 
ATOM   1950 C CA  . LEU A 1 293 ? 9.595   -16.998 29.287 1.00 70.75  ? 325 LEU A CA  1 ? 
ATOM   1951 C C   . LEU A 1 293 ? 10.029  -18.345 29.858 1.00 69.00  ? 325 LEU A C   1 ? 
ATOM   1952 O O   . LEU A 1 293 ? 11.208  -18.570 30.117 1.00 74.13  ? 325 LEU A O   1 ? 
ATOM   1953 C CB  . LEU A 1 293 ? 9.813   -16.959 27.781 1.00 63.49  ? 325 LEU A CB  1 ? 
ATOM   1954 C CG  . LEU A 1 293 ? 9.374   -15.670 27.100 1.00 62.72  ? 325 LEU A CG  1 ? 
ATOM   1955 C CD1 . LEU A 1 293 ? 9.686   -15.821 25.622 1.00 67.88  ? 325 LEU A CD1 1 ? 
ATOM   1956 C CD2 . LEU A 1 293 ? 7.885   -15.433 27.393 1.00 62.97  ? 325 LEU A CD2 1 ? 
ATOM   1957 N N   . PRO A 1 294 ? 9.087   -19.290 30.069 1.00 71.95  ? 326 PRO A N   1 ? 
ATOM   1958 C CA  . PRO A 1 294 ? 9.453   -20.692 30.250 1.00 77.44  ? 326 PRO A CA  1 ? 
ATOM   1959 C C   . PRO A 1 294 ? 10.222  -21.238 29.048 1.00 78.27  ? 326 PRO A C   1 ? 
ATOM   1960 O O   . PRO A 1 294 ? 10.042  -20.762 27.930 1.00 74.51  ? 326 PRO A O   1 ? 
ATOM   1961 C CB  . PRO A 1 294 ? 8.073   -21.345 30.413 1.00 79.23  ? 326 PRO A CB  1 ? 
ATOM   1962 C CG  . PRO A 1 294 ? 7.143   -20.418 29.679 1.00 74.53  ? 326 PRO A CG  1 ? 
ATOM   1963 C CD  . PRO A 1 294 ? 7.633   -19.070 30.146 1.00 75.27  ? 326 PRO A CD  1 ? 
ATOM   1964 N N   . SER A 1 295 ? 11.072  -22.240 29.295 1.00 76.46  ? 327 SER A N   1 ? 
ATOM   1965 C CA  . SER A 1 295 ? 11.831  -22.894 28.240 1.00 82.78  ? 327 SER A CA  1 ? 
ATOM   1966 C C   . SER A 1 295 ? 10.969  -23.982 27.605 1.00 87.91  ? 327 SER A C   1 ? 
ATOM   1967 O O   . SER A 1 295 ? 9.914   -24.340 28.135 1.00 86.07  ? 327 SER A O   1 ? 
ATOM   1968 C CB  . SER A 1 295 ? 13.110  -23.479 28.776 1.00 85.48  ? 327 SER A CB  1 ? 
ATOM   1969 O OG  . SER A 1 295 ? 13.564  -22.769 29.918 1.00 86.76  ? 327 SER A OG  1 ? 
ATOM   1970 N N   . GLY A 1 296 ? 11.438  -24.510 26.469 1.00 83.53  ? 328 GLY A N   1 ? 
ATOM   1971 C CA  . GLY A 1 296 ? 10.781  -25.628 25.811 1.00 81.50  ? 328 GLY A CA  1 ? 
ATOM   1972 C C   . GLY A 1 296 ? 9.621   -25.173 24.927 1.00 81.54  ? 328 GLY A C   1 ? 
ATOM   1973 O O   . GLY A 1 296 ? 9.485   -25.655 23.805 1.00 91.07  ? 328 GLY A O   1 ? 
ATOM   1974 N N   . VAL A 1 297 ? 8.809   -24.238 25.441 1.00 75.05  ? 329 VAL A N   1 ? 
ATOM   1975 C CA  . VAL A 1 297 ? 7.556   -23.809 24.826 1.00 79.28  ? 329 VAL A CA  1 ? 
ATOM   1976 C C   . VAL A 1 297 ? 7.759   -22.666 23.824 1.00 74.08  ? 329 VAL A C   1 ? 
ATOM   1977 O O   . VAL A 1 297 ? 6.951   -22.499 22.914 1.00 67.48  ? 329 VAL A O   1 ? 
ATOM   1978 C CB  . VAL A 1 297 ? 6.592   -23.354 25.940 1.00 85.11  ? 329 VAL A CB  1 ? 
ATOM   1979 C CG1 . VAL A 1 297 ? 5.316   -22.749 25.369 1.00 102.03 ? 329 VAL A CG1 1 ? 
ATOM   1980 C CG2 . VAL A 1 297 ? 6.277   -24.476 26.923 1.00 85.43  ? 329 VAL A CG2 1 ? 
ATOM   1981 N N   . PHE A 1 298 ? 8.786   -21.838 24.045 1.00 72.00  ? 330 PHE A N   1 ? 
ATOM   1982 C CA  . PHE A 1 298 ? 9.078   -20.694 23.197 1.00 65.42  ? 330 PHE A CA  1 ? 
ATOM   1983 C C   . PHE A 1 298 ? 10.459  -20.844 22.567 1.00 64.13  ? 330 PHE A C   1 ? 
ATOM   1984 O O   . PHE A 1 298 ? 11.386  -21.335 23.202 1.00 58.62  ? 330 PHE A O   1 ? 
ATOM   1985 C CB  . PHE A 1 298 ? 9.017   -19.421 24.044 1.00 63.00  ? 330 PHE A CB  1 ? 
ATOM   1986 C CG  . PHE A 1 298 ? 7.633   -19.193 24.627 1.00 67.11  ? 330 PHE A CG  1 ? 
ATOM   1987 C CD1 . PHE A 1 298 ? 6.610   -18.691 23.831 1.00 67.95  ? 330 PHE A CD1 1 ? 
ATOM   1988 C CD2 . PHE A 1 298 ? 7.356   -19.483 25.960 1.00 63.23  ? 330 PHE A CD2 1 ? 
ATOM   1989 C CE1 . PHE A 1 298 ? 5.346   -18.490 24.358 1.00 64.37  ? 330 PHE A CE1 1 ? 
ATOM   1990 C CE2 . PHE A 1 298 ? 6.083   -19.283 26.477 1.00 61.32  ? 330 PHE A CE2 1 ? 
ATOM   1991 C CZ  . PHE A 1 298 ? 5.088   -18.789 25.679 1.00 59.84  ? 330 PHE A CZ  1 ? 
ATOM   1992 N N   . SER A 1 299 ? 10.601  -20.347 21.335 1.00 60.38  ? 331 SER A N   1 ? 
ATOM   1993 C CA  . SER A 1 299 ? 11.867  -20.402 20.624 1.00 61.03  ? 331 SER A CA  1 ? 
ATOM   1994 C C   . SER A 1 299 ? 12.970  -19.744 21.457 1.00 63.92  ? 331 SER A C   1 ? 
ATOM   1995 O O   . SER A 1 299 ? 12.707  -18.817 22.232 1.00 56.46  ? 331 SER A O   1 ? 
ATOM   1996 C CB  . SER A 1 299 ? 11.766  -19.756 19.247 1.00 53.41  ? 331 SER A CB  1 ? 
ATOM   1997 O OG  . SER A 1 299 ? 11.915  -18.344 19.335 1.00 59.09  ? 331 SER A OG  1 ? 
ATOM   1998 N N   . LEU A 1 300 ? 14.210  -20.220 21.245 1.00 63.38  ? 332 LEU A N   1 ? 
ATOM   1999 C CA  . LEU A 1 300 ? 15.394  -19.671 21.891 1.00 62.66  ? 332 LEU A CA  1 ? 
ATOM   2000 C C   . LEU A 1 300 ? 15.626  -18.243 21.392 1.00 57.66  ? 332 LEU A C   1 ? 
ATOM   2001 O O   . LEU A 1 300 ? 15.967  -17.362 22.172 1.00 52.45  ? 332 LEU A O   1 ? 
ATOM   2002 C CB  . LEU A 1 300 ? 16.585  -20.597 21.631 1.00 69.36  ? 332 LEU A CB  1 ? 
ATOM   2003 C CG  . LEU A 1 300 ? 16.464  -22.026 22.184 1.00 74.69  ? 332 LEU A CG  1 ? 
ATOM   2004 C CD1 . LEU A 1 300 ? 17.440  -22.972 21.488 1.00 70.96  ? 332 LEU A CD1 1 ? 
ATOM   2005 C CD2 . LEU A 1 300 ? 16.669  -22.073 23.698 1.00 67.98  ? 332 LEU A CD2 1 ? 
ATOM   2006 N N   . GLU A 1 301 ? 15.363  -17.989 20.104 1.00 52.10  ? 333 GLU A N   1 ? 
ATOM   2007 C CA  . GLU A 1 301 ? 15.364  -16.628 19.598 1.00 55.07  ? 333 GLU A CA  1 ? 
ATOM   2008 C C   . GLU A 1 301 ? 14.443  -15.754 20.445 1.00 60.18  ? 333 GLU A C   1 ? 
ATOM   2009 O O   . GLU A 1 301 ? 14.854  -14.683 20.875 1.00 63.52  ? 333 GLU A O   1 ? 
ATOM   2010 C CB  . GLU A 1 301 ? 14.917  -16.603 18.137 1.00 62.31  ? 333 GLU A CB  1 ? 
ATOM   2011 C CG  . GLU A 1 301 ? 15.978  -17.120 17.176 1.00 70.23  ? 333 GLU A CG  1 ? 
ATOM   2012 C CD  . GLU A 1 301 ? 15.451  -18.019 16.080 1.00 89.75  ? 333 GLU A CD  1 ? 
ATOM   2013 O OE1 . GLU A 1 301 ? 14.830  -19.065 16.405 1.00 102.67 ? 333 GLU A OE1 1 ? 
ATOM   2014 O OE2 . GLU A 1 301 ? 15.698  -17.678 14.901 1.00 96.51  ? 333 GLU A OE2 1 ? 
ATOM   2015 N N   . PHE A 1 302 ? 13.199  -16.216 20.674 1.00 66.35  ? 334 PHE A N   1 ? 
ATOM   2016 C CA  . PHE A 1 302 ? 12.182  -15.405 21.333 1.00 62.53  ? 334 PHE A CA  1 ? 
ATOM   2017 C C   . PHE A 1 302 ? 12.613  -15.160 22.774 1.00 48.57  ? 334 PHE A C   1 ? 
ATOM   2018 O O   . PHE A 1 302 ? 12.551  -14.037 23.258 1.00 50.83  ? 334 PHE A O   1 ? 
ATOM   2019 C CB  . PHE A 1 302 ? 10.771  -16.012 21.298 1.00 69.91  ? 334 PHE A CB  1 ? 
ATOM   2020 C CG  . PHE A 1 302 ? 9.628   -15.132 21.811 1.00 67.18  ? 334 PHE A CG  1 ? 
ATOM   2021 C CD1 . PHE A 1 302 ? 9.621   -13.749 21.612 1.00 70.92  ? 334 PHE A CD1 1 ? 
ATOM   2022 C CD2 . PHE A 1 302 ? 8.544   -15.695 22.479 1.00 67.88  ? 334 PHE A CD2 1 ? 
ATOM   2023 C CE1 . PHE A 1 302 ? 8.574   -12.961 22.079 1.00 65.55  ? 334 PHE A CE1 1 ? 
ATOM   2024 C CE2 . PHE A 1 302 ? 7.496   -14.906 22.941 1.00 65.67  ? 334 PHE A CE2 1 ? 
ATOM   2025 C CZ  . PHE A 1 302 ? 7.511   -13.545 22.742 1.00 63.64  ? 334 PHE A CZ  1 ? 
ATOM   2026 N N   . GLN A 1 303 ? 13.110  -16.202 23.430 1.00 49.60  ? 335 GLN A N   1 ? 
ATOM   2027 C CA  . GLN A 1 303 ? 13.557  -16.067 24.810 1.00 63.06  ? 335 GLN A CA  1 ? 
ATOM   2028 C C   . GLN A 1 303 ? 14.720  -15.079 24.906 1.00 67.34  ? 335 GLN A C   1 ? 
ATOM   2029 O O   . GLN A 1 303 ? 14.798  -14.285 25.854 1.00 58.04  ? 335 GLN A O   1 ? 
ATOM   2030 C CB  . GLN A 1 303 ? 14.041  -17.414 25.337 1.00 67.33  ? 335 GLN A CB  1 ? 
ATOM   2031 C CG  . GLN A 1 303 ? 12.953  -18.473 25.396 1.00 67.91  ? 335 GLN A CG  1 ? 
ATOM   2032 C CD  . GLN A 1 303 ? 13.506  -19.854 25.659 1.00 74.27  ? 335 GLN A CD  1 ? 
ATOM   2033 O OE1 . GLN A 1 303 ? 13.417  -20.748 24.809 1.00 67.49  ? 335 GLN A OE1 1 ? 
ATOM   2034 N NE2 . GLN A 1 303 ? 14.089  -20.027 26.838 1.00 68.00  ? 335 GLN A NE2 1 ? 
ATOM   2035 N N   . ASP A 1 304 ? 15.617  -15.142 23.911 1.00 66.20  ? 336 ASP A N   1 ? 
ATOM   2036 C CA  . ASP A 1 304 ? 16.782  -14.273 23.894 1.00 71.13  ? 336 ASP A CA  1 ? 
ATOM   2037 C C   . ASP A 1 304 ? 16.332  -12.823 23.747 1.00 69.57  ? 336 ASP A C   1 ? 
ATOM   2038 O O   . ASP A 1 304 ? 16.778  -11.982 24.520 1.00 61.88  ? 336 ASP A O   1 ? 
ATOM   2039 C CB  . ASP A 1 304 ? 17.817  -14.639 22.839 1.00 72.23  ? 336 ASP A CB  1 ? 
ATOM   2040 C CG  . ASP A 1 304 ? 19.126  -13.879 22.999 1.00 71.73  ? 336 ASP A CG  1 ? 
ATOM   2041 O OD1 . ASP A 1 304 ? 19.776  -14.088 24.041 1.00 75.80  ? 336 ASP A OD1 1 ? 
ATOM   2042 O OD2 . ASP A 1 304 ? 19.441  -13.031 22.128 1.00 68.74  ? 336 ASP A OD2 1 ? 
ATOM   2043 N N   . PHE A 1 305 ? 15.457  -12.557 22.766 1.00 65.25  ? 337 PHE A N   1 ? 
ATOM   2044 C CA  . PHE A 1 305 ? 14.888  -11.234 22.547 1.00 69.75  ? 337 PHE A CA  1 ? 
ATOM   2045 C C   . PHE A 1 305 ? 14.300  -10.646 23.839 1.00 69.21  ? 337 PHE A C   1 ? 
ATOM   2046 O O   . PHE A 1 305 ? 14.630  -9.524  24.216 1.00 59.43  ? 337 PHE A O   1 ? 
ATOM   2047 C CB  . PHE A 1 305 ? 13.832  -11.338 21.443 1.00 69.50  ? 337 PHE A CB  1 ? 
ATOM   2048 C CG  . PHE A 1 305 ? 13.146  -10.027 21.082 1.00 73.22  ? 337 PHE A CG  1 ? 
ATOM   2049 C CD1 . PHE A 1 305 ? 13.672  -9.190  20.103 1.00 71.52  ? 337 PHE A CD1 1 ? 
ATOM   2050 C CD2 . PHE A 1 305 ? 11.959  -9.643  21.712 1.00 79.43  ? 337 PHE A CD2 1 ? 
ATOM   2051 C CE1 . PHE A 1 305 ? 13.035  -7.998  19.773 1.00 74.93  ? 337 PHE A CE1 1 ? 
ATOM   2052 C CE2 . PHE A 1 305 ? 11.322  -8.451  21.377 1.00 73.17  ? 337 PHE A CE2 1 ? 
ATOM   2053 C CZ  . PHE A 1 305 ? 11.865  -7.627  20.418 1.00 77.62  ? 337 PHE A CZ  1 ? 
ATOM   2054 N N   . VAL A 1 306 ? 13.413  -11.374 24.526 1.00 65.43  ? 338 VAL A N   1 ? 
ATOM   2055 C CA  . VAL A 1 306 ? 12.756  -10.775 25.677 1.00 69.01  ? 338 VAL A CA  1 ? 
ATOM   2056 C C   . VAL A 1 306 ? 13.814  -10.591 26.769 1.00 64.95  ? 338 VAL A C   1 ? 
ATOM   2057 O O   . VAL A 1 306 ? 13.779  -9.604  27.498 1.00 65.44  ? 338 VAL A O   1 ? 
ATOM   2058 C CB  . VAL A 1 306 ? 11.488  -11.471 26.230 1.00 72.18  ? 338 VAL A CB  1 ? 
ATOM   2059 C CG1 . VAL A 1 306 ? 10.541  -11.953 25.131 1.00 72.46  ? 338 VAL A CG1 1 ? 
ATOM   2060 C CG2 . VAL A 1 306 ? 11.803  -12.617 27.175 1.00 77.28  ? 338 VAL A CG2 1 ? 
ATOM   2061 N N   . ASN A 1 307 ? 14.756  -11.539 26.883 1.00 69.52  ? 339 ASN A N   1 ? 
ATOM   2062 C CA  . ASN A 1 307 ? 15.849  -11.439 27.848 1.00 71.93  ? 339 ASN A CA  1 ? 
ATOM   2063 C C   . ASN A 1 307 ? 16.640  -10.132 27.686 1.00 67.42  ? 339 ASN A C   1 ? 
ATOM   2064 O O   . ASN A 1 307 ? 17.013  -9.510  28.679 1.00 67.14  ? 339 ASN A O   1 ? 
ATOM   2065 C CB  . ASN A 1 307 ? 16.780  -12.644 27.754 1.00 72.57  ? 339 ASN A CB  1 ? 
ATOM   2066 C CG  . ASN A 1 307 ? 16.274  -13.858 28.499 1.00 71.58  ? 339 ASN A CG  1 ? 
ATOM   2067 O OD1 . ASN A 1 307 ? 15.290  -13.785 29.246 1.00 71.35  ? 339 ASN A OD1 1 ? 
ATOM   2068 N ND2 . ASN A 1 307 ? 16.950  -14.983 28.317 1.00 71.62  ? 339 ASN A ND2 1 ? 
ATOM   2069 N N   . LYS A 1 308 ? 16.863  -9.707  26.436 1.00 61.58  ? 340 LYS A N   1 ? 
ATOM   2070 C CA  . LYS A 1 308 ? 17.564  -8.468  26.126 1.00 71.75  ? 340 LYS A CA  1 ? 
ATOM   2071 C C   . LYS A 1 308 ? 16.721  -7.220  26.405 1.00 73.95  ? 340 LYS A C   1 ? 
ATOM   2072 O O   . LYS A 1 308 ? 17.298  -6.148  26.571 1.00 81.19  ? 340 LYS A O   1 ? 
ATOM   2073 C CB  . LYS A 1 308 ? 18.045  -8.474  24.667 1.00 76.84  ? 340 LYS A CB  1 ? 
ATOM   2074 C CG  . LYS A 1 308 ? 19.293  -9.330  24.470 1.00 86.64  ? 340 LYS A CG  1 ? 
ATOM   2075 C CD  . LYS A 1 308 ? 19.660  -9.673  23.031 1.00 99.36  ? 340 LYS A CD  1 ? 
ATOM   2076 C CE  . LYS A 1 308 ? 21.106  -10.067 22.851 1.00 100.49 ? 340 LYS A CE  1 ? 
ATOM   2077 N NZ  . LYS A 1 308 ? 21.527  -11.161 23.731 1.00 99.00  ? 340 LYS A NZ  1 ? 
ATOM   2078 N N   . CYS A 1 309 ? 15.381  -7.338  26.435 1.00 65.81  ? 341 CYS A N   1 ? 
ATOM   2079 C CA  . CYS A 1 309 ? 14.506  -6.211  26.747 1.00 68.83  ? 341 CYS A CA  1 ? 
ATOM   2080 C C   . CYS A 1 309 ? 14.395  -5.983  28.255 1.00 65.97  ? 341 CYS A C   1 ? 
ATOM   2081 O O   . CYS A 1 309 ? 14.003  -4.900  28.689 1.00 69.59  ? 341 CYS A O   1 ? 
ATOM   2082 C CB  . CYS A 1 309 ? 13.075  -6.422  26.258 1.00 71.83  ? 341 CYS A CB  1 ? 
ATOM   2083 S SG  . CYS A 1 309 ? 12.914  -6.491  24.455 1.00 72.71  ? 341 CYS A SG  1 ? 
ATOM   2084 N N   . LEU A 1 310 ? 14.704  -7.020  29.040 1.00 68.30  ? 342 LEU A N   1 ? 
ATOM   2085 C CA  . LEU A 1 310 ? 14.366  -7.043  30.454 1.00 75.52  ? 342 LEU A CA  1 ? 
ATOM   2086 C C   . LEU A 1 310 ? 15.633  -7.123  31.305 1.00 80.41  ? 342 LEU A C   1 ? 
ATOM   2087 O O   . LEU A 1 310 ? 15.562  -7.487  32.476 1.00 81.91  ? 342 LEU A O   1 ? 
ATOM   2088 C CB  . LEU A 1 310 ? 13.419  -8.215  30.717 1.00 71.89  ? 342 LEU A CB  1 ? 
ATOM   2089 C CG  . LEU A 1 310 ? 11.958  -8.021  30.296 1.00 72.81  ? 342 LEU A CG  1 ? 
ATOM   2090 C CD1 . LEU A 1 310 ? 11.237  -9.365  30.172 1.00 72.28  ? 342 LEU A CD1 1 ? 
ATOM   2091 C CD2 . LEU A 1 310 ? 11.243  -7.113  31.284 1.00 69.83  ? 342 LEU A CD2 1 ? 
ATOM   2092 N N   . ILE A 1 311 ? 16.783  -6.766  30.718 1.00 84.32  ? 343 ILE A N   1 ? 
ATOM   2093 C CA  . ILE A 1 311 ? 17.983  -6.476  31.490 1.00 78.95  ? 343 ILE A CA  1 ? 
ATOM   2094 C C   . ILE A 1 311 ? 17.708  -5.254  32.370 1.00 78.39  ? 343 ILE A C   1 ? 
ATOM   2095 O O   . ILE A 1 311 ? 17.278  -4.207  31.887 1.00 77.77  ? 343 ILE A O   1 ? 
ATOM   2096 C CB  . ILE A 1 311 ? 19.197  -6.280  30.561 1.00 77.89  ? 343 ILE A CB  1 ? 
ATOM   2097 C CG1 . ILE A 1 311 ? 19.527  -7.553  29.797 1.00 75.54  ? 343 ILE A CG1 1 ? 
ATOM   2098 C CG2 . ILE A 1 311 ? 20.423  -5.789  31.331 1.00 84.90  ? 343 ILE A CG2 1 ? 
ATOM   2099 C CD1 . ILE A 1 311 ? 20.455  -7.341  28.618 1.00 78.29  ? 343 ILE A CD1 1 ? 
ATOM   2100 N N   . LYS A 1 312 ? 17.981  -5.409  33.670 1.00 82.17  ? 344 LYS A N   1 ? 
ATOM   2101 C CA  . LYS A 1 312 ? 17.619  -4.443  34.699 1.00 89.50  ? 344 LYS A CA  1 ? 
ATOM   2102 C C   . LYS A 1 312 ? 18.359  -3.119  34.514 1.00 89.13  ? 344 LYS A C   1 ? 
ATOM   2103 O O   . LYS A 1 312 ? 17.778  -2.050  34.704 1.00 90.29  ? 344 LYS A O   1 ? 
ATOM   2104 C CB  . LYS A 1 312 ? 18.004  -5.005  36.072 1.00 95.14  ? 344 LYS A CB  1 ? 
ATOM   2105 C CG  . LYS A 1 312 ? 17.453  -6.388  36.393 1.00 96.99  ? 344 LYS A CG  1 ? 
ATOM   2106 C CD  . LYS A 1 312 ? 16.272  -6.381  37.348 1.00 90.33  ? 344 LYS A CD  1 ? 
ATOM   2107 C CE  . LYS A 1 312 ? 16.749  -6.206  38.743 1.00 95.23  ? 344 LYS A CE  1 ? 
ATOM   2108 N NZ  . LYS A 1 312 ? 15.653  -6.370  39.692 1.00 103.64 ? 344 LYS A NZ  1 ? 
ATOM   2109 N N   . ASN A 1 313 ? 19.653  -3.203  34.189 1.00 89.07  ? 345 ASN A N   1 ? 
ATOM   2110 C CA  . ASN A 1 313 ? 20.476  -2.017  34.013 1.00 98.55  ? 345 ASN A CA  1 ? 
ATOM   2111 C C   . ASN A 1 313 ? 20.272  -1.502  32.589 1.00 89.93  ? 345 ASN A C   1 ? 
ATOM   2112 O O   . ASN A 1 313 ? 20.613  -2.185  31.625 1.00 91.01  ? 345 ASN A O   1 ? 
ATOM   2113 C CB  . ASN A 1 313 ? 21.918  -2.305  34.428 1.00 106.82 ? 345 ASN A CB  1 ? 
ATOM   2114 C CG  . ASN A 1 313 ? 22.929  -1.350  33.837 1.00 110.08 ? 345 ASN A CG  1 ? 
ATOM   2115 O OD1 . ASN A 1 313 ? 22.634  -0.167  33.623 1.00 98.60  ? 345 ASN A OD1 1 ? 
ATOM   2116 N ND2 . ASN A 1 313 ? 24.125  -1.850  33.552 1.00 114.56 ? 345 ASN A ND2 1 ? 
ATOM   2117 N N   . PRO A 1 314 ? 19.703  -0.286  32.411 1.00 81.19  ? 346 PRO A N   1 ? 
ATOM   2118 C CA  . PRO A 1 314 ? 19.381  0.218   31.072 1.00 79.46  ? 346 PRO A CA  1 ? 
ATOM   2119 C C   . PRO A 1 314 ? 20.582  0.472   30.163 1.00 90.48  ? 346 PRO A C   1 ? 
ATOM   2120 O O   . PRO A 1 314 ? 20.420  0.577   28.948 1.00 94.55  ? 346 PRO A O   1 ? 
ATOM   2121 C CB  . PRO A 1 314 ? 18.607  1.505   31.366 1.00 78.51  ? 346 PRO A CB  1 ? 
ATOM   2122 C CG  . PRO A 1 314 ? 19.135  1.952   32.713 1.00 79.45  ? 346 PRO A CG  1 ? 
ATOM   2123 C CD  . PRO A 1 314 ? 19.338  0.657   33.481 1.00 81.20  ? 346 PRO A CD  1 ? 
ATOM   2124 N N   . ALA A 1 315 ? 21.777  0.590   30.758 1.00 95.51  ? 347 ALA A N   1 ? 
ATOM   2125 C CA  . ALA A 1 315 ? 23.006  0.738   29.994 1.00 102.75 ? 347 ALA A CA  1 ? 
ATOM   2126 C C   . ALA A 1 315 ? 23.313  -0.552  29.237 1.00 108.39 ? 347 ALA A C   1 ? 
ATOM   2127 O O   . ALA A 1 315 ? 23.871  -0.504  28.143 1.00 103.91 ? 347 ALA A O   1 ? 
ATOM   2128 C CB  . ALA A 1 315 ? 24.156  1.116   30.903 1.00 106.54 ? 347 ALA A CB  1 ? 
ATOM   2129 N N   . GLU A 1 316 ? 22.952  -1.696  29.838 1.00 111.27 ? 348 GLU A N   1 ? 
ATOM   2130 C CA  . GLU A 1 316 ? 23.180  -3.003  29.240 1.00 109.72 ? 348 GLU A CA  1 ? 
ATOM   2131 C C   . GLU A 1 316 ? 21.985  -3.425  28.386 1.00 104.44 ? 348 GLU A C   1 ? 
ATOM   2132 O O   . GLU A 1 316 ? 22.164  -4.100  27.375 1.00 99.48  ? 348 GLU A O   1 ? 
ATOM   2133 C CB  . GLU A 1 316 ? 23.484  -4.036  30.324 1.00 111.10 ? 348 GLU A CB  1 ? 
ATOM   2134 C CG  . GLU A 1 316 ? 24.964  -4.102  30.685 1.00 118.43 ? 348 GLU A CG  1 ? 
ATOM   2135 C CD  . GLU A 1 316 ? 25.245  -4.865  31.966 1.00 123.56 ? 348 GLU A CD  1 ? 
ATOM   2136 O OE1 . GLU A 1 316 ? 24.505  -5.841  32.210 1.00 125.64 ? 348 GLU A OE1 1 ? 
ATOM   2137 O OE2 . GLU A 1 316 ? 26.197  -4.512  32.701 1.00 113.35 ? 348 GLU A OE2 1 ? 
ATOM   2138 N N   . ARG A 1 317 ? 20.776  -3.020  28.799 1.00 97.38  ? 349 ARG A N   1 ? 
ATOM   2139 C CA  . ARG A 1 317 ? 19.548  -3.352  28.090 1.00 92.94  ? 349 ARG A CA  1 ? 
ATOM   2140 C C   . ARG A 1 317 ? 19.622  -2.847  26.652 1.00 83.24  ? 349 ARG A C   1 ? 
ATOM   2141 O O   . ARG A 1 317 ? 20.217  -1.808  26.386 1.00 93.28  ? 349 ARG A O   1 ? 
ATOM   2142 C CB  . ARG A 1 317 ? 18.344  -2.738  28.816 1.00 92.30  ? 349 ARG A CB  1 ? 
ATOM   2143 C CG  . ARG A 1 317 ? 16.979  -2.954  28.173 1.00 89.03  ? 349 ARG A CG  1 ? 
ATOM   2144 C CD  . ARG A 1 317 ? 15.875  -2.162  28.868 1.00 76.62  ? 349 ARG A CD  1 ? 
ATOM   2145 N NE  . ARG A 1 317 ? 15.901  -2.413  30.311 1.00 69.04  ? 349 ARG A NE  1 ? 
ATOM   2146 C CZ  . ARG A 1 317 ? 15.711  -1.514  31.270 1.00 68.37  ? 349 ARG A CZ  1 ? 
ATOM   2147 N NH1 . ARG A 1 317 ? 15.144  -0.357  31.003 1.00 66.75  ? 349 ARG A NH1 1 ? 
ATOM   2148 N NH2 . ARG A 1 317 ? 16.022  -1.809  32.521 1.00 72.13  ? 349 ARG A NH2 1 ? 
ATOM   2149 N N   . ALA A 1 318 ? 18.976  -3.585  25.743 1.00 76.93  ? 350 ALA A N   1 ? 
ATOM   2150 C CA  . ALA A 1 318 ? 19.057  -3.329  24.313 1.00 83.83  ? 350 ALA A CA  1 ? 
ATOM   2151 C C   . ALA A 1 318 ? 18.371  -2.014  23.952 1.00 83.11  ? 350 ALA A C   1 ? 
ATOM   2152 O O   . ALA A 1 318 ? 17.406  -1.615  24.594 1.00 85.25  ? 350 ALA A O   1 ? 
ATOM   2153 C CB  . ALA A 1 318 ? 18.442  -4.483  23.545 1.00 81.44  ? 350 ALA A CB  1 ? 
ATOM   2154 N N   . ASP A 1 319 ? 18.903  -1.338  22.930 1.00 83.25  ? 351 ASP A N   1 ? 
ATOM   2155 C CA  . ASP A 1 319 ? 18.263  -0.162  22.369 1.00 81.32  ? 351 ASP A CA  1 ? 
ATOM   2156 C C   . ASP A 1 319 ? 17.477  -0.606  21.138 1.00 79.00  ? 351 ASP A C   1 ? 
ATOM   2157 O O   . ASP A 1 319 ? 17.605  -1.740  20.690 1.00 78.24  ? 351 ASP A O   1 ? 
ATOM   2158 C CB  . ASP A 1 319 ? 19.262  0.960   22.116 1.00 85.33  ? 351 ASP A CB  1 ? 
ATOM   2159 C CG  . ASP A 1 319 ? 20.423  0.644   21.179 1.00 101.60 ? 351 ASP A CG  1 ? 
ATOM   2160 O OD1 . ASP A 1 319 ? 20.159  0.187   20.037 1.00 101.14 ? 351 ASP A OD1 1 ? 
ATOM   2161 O OD2 . ASP A 1 319 ? 21.589  0.883   21.590 1.00 98.42  ? 351 ASP A OD2 1 ? 
ATOM   2162 N N   . LEU A 1 320 ? 16.665  0.304   20.598 1.00 74.03  ? 352 LEU A N   1 ? 
ATOM   2163 C CA  . LEU A 1 320 ? 15.834  0.007   19.449 1.00 71.30  ? 352 LEU A CA  1 ? 
ATOM   2164 C C   . LEU A 1 320 ? 16.639  -0.615  18.306 1.00 75.25  ? 352 LEU A C   1 ? 
ATOM   2165 O O   . LEU A 1 320 ? 16.167  -1.564  17.685 1.00 83.62  ? 352 LEU A O   1 ? 
ATOM   2166 C CB  . LEU A 1 320 ? 15.111  1.282   19.025 1.00 72.47  ? 352 LEU A CB  1 ? 
ATOM   2167 C CG  . LEU A 1 320 ? 14.091  1.842   20.024 1.00 76.70  ? 352 LEU A CG  1 ? 
ATOM   2168 C CD1 . LEU A 1 320 ? 13.220  2.852   19.307 1.00 88.66  ? 352 LEU A CD1 1 ? 
ATOM   2169 C CD2 . LEU A 1 320 ? 13.189  0.820   20.672 1.00 77.26  ? 352 LEU A CD2 1 ? 
ATOM   2170 N N   . LYS A 1 321 ? 17.846  -0.103  18.030 1.00 84.94  ? 353 LYS A N   1 ? 
ATOM   2171 C CA  . LYS A 1 321 ? 18.582  -0.500  16.835 1.00 93.33  ? 353 LYS A CA  1 ? 
ATOM   2172 C C   . LYS A 1 321 ? 18.936  -1.986  16.880 1.00 82.86  ? 353 LYS A C   1 ? 
ATOM   2173 O O   . LYS A 1 321 ? 18.866  -2.674  15.862 1.00 83.86  ? 353 LYS A O   1 ? 
ATOM   2174 C CB  . LYS A 1 321 ? 19.861  0.312   16.582 1.00 109.02 ? 353 LYS A CB  1 ? 
ATOM   2175 C CG  . LYS A 1 321 ? 19.763  1.289   15.417 1.00 117.70 ? 353 LYS A CG  1 ? 
ATOM   2176 C CD  . LYS A 1 321 ? 19.120  2.626   15.759 1.00 130.85 ? 353 LYS A CD  1 ? 
ATOM   2177 C CE  . LYS A 1 321 ? 20.097  3.576   16.374 1.00 140.27 ? 353 LYS A CE  1 ? 
ATOM   2178 N NZ  . LYS A 1 321 ? 21.055  4.085   15.387 1.00 145.55 ? 353 LYS A NZ  1 ? 
ATOM   2179 N N   . GLN A 1 322 ? 19.313  -2.465  18.066 1.00 76.49  ? 354 GLN A N   1 ? 
ATOM   2180 C CA  . GLN A 1 322 ? 19.721  -3.847  18.262 1.00 79.34  ? 354 GLN A CA  1 ? 
ATOM   2181 C C   . GLN A 1 322 ? 18.507  -4.774  18.130 1.00 80.98  ? 354 GLN A C   1 ? 
ATOM   2182 O O   . GLN A 1 322 ? 18.623  -5.884  17.611 1.00 91.30  ? 354 GLN A O   1 ? 
ATOM   2183 C CB  . GLN A 1 322 ? 20.412  -3.972  19.621 1.00 82.90  ? 354 GLN A CB  1 ? 
ATOM   2184 C CG  . GLN A 1 322 ? 21.557  -2.987  19.850 1.00 86.16  ? 354 GLN A CG  1 ? 
ATOM   2185 C CD  . GLN A 1 322 ? 22.126  -3.053  21.252 1.00 99.19  ? 354 GLN A CD  1 ? 
ATOM   2186 O OE1 . GLN A 1 322 ? 21.564  -2.494  22.203 1.00 98.67  ? 354 GLN A OE1 1 ? 
ATOM   2187 N NE2 . GLN A 1 322 ? 23.262  -3.726  21.393 1.00 97.39  ? 354 GLN A NE2 1 ? 
ATOM   2188 N N   . LEU A 1 323 ? 17.342  -4.305  18.597 1.00 79.59  ? 355 LEU A N   1 ? 
ATOM   2189 C CA  . LEU A 1 323 ? 16.114  -5.082  18.555 1.00 73.77  ? 355 LEU A CA  1 ? 
ATOM   2190 C C   . LEU A 1 323 ? 15.709  -5.273  17.103 1.00 73.77  ? 355 LEU A C   1 ? 
ATOM   2191 O O   . LEU A 1 323 ? 15.325  -6.363  16.691 1.00 70.50  ? 355 LEU A O   1 ? 
ATOM   2192 C CB  . LEU A 1 323 ? 15.004  -4.387  19.343 1.00 74.14  ? 355 LEU A CB  1 ? 
ATOM   2193 C CG  . LEU A 1 323 ? 15.246  -4.182  20.843 1.00 69.37  ? 355 LEU A CG  1 ? 
ATOM   2194 C CD1 . LEU A 1 323 ? 14.057  -3.481  21.472 1.00 78.08  ? 355 LEU A CD1 1 ? 
ATOM   2195 C CD2 . LEU A 1 323 ? 15.510  -5.465  21.582 1.00 67.44  ? 355 LEU A CD2 1 ? 
ATOM   2196 N N   . MET A 1 324 ? 15.852  -4.204  16.322 1.00 74.66  ? 356 MET A N   1 ? 
ATOM   2197 C CA  . MET A 1 324 ? 15.465  -4.227  14.923 1.00 75.84  ? 356 MET A CA  1 ? 
ATOM   2198 C C   . MET A 1 324 ? 16.245  -5.288  14.135 1.00 74.04  ? 356 MET A C   1 ? 
ATOM   2199 O O   . MET A 1 324 ? 15.775  -5.721  13.080 1.00 68.68  ? 356 MET A O   1 ? 
ATOM   2200 C CB  . MET A 1 324 ? 15.661  -2.834  14.321 1.00 87.65  ? 356 MET A CB  1 ? 
ATOM   2201 C CG  . MET A 1 324 ? 14.590  -2.459  13.333 1.00 102.33 ? 356 MET A CG  1 ? 
ATOM   2202 S SD  . MET A 1 324 ? 12.974  -2.457  14.130 1.00 116.53 ? 356 MET A SD  1 ? 
ATOM   2203 C CE  . MET A 1 324 ? 11.971  -2.916  12.713 1.00 111.53 ? 356 MET A CE  1 ? 
ATOM   2204 N N   . VAL A 1 325 ? 17.414  -5.727  14.649 1.00 73.74  ? 357 VAL A N   1 ? 
ATOM   2205 C CA  . VAL A 1 325 ? 18.277  -6.659  13.930 1.00 76.10  ? 357 VAL A CA  1 ? 
ATOM   2206 C C   . VAL A 1 325 ? 18.549  -7.908  14.773 1.00 74.41  ? 357 VAL A C   1 ? 
ATOM   2207 O O   . VAL A 1 325 ? 19.433  -8.696  14.437 1.00 72.37  ? 357 VAL A O   1 ? 
ATOM   2208 C CB  . VAL A 1 325 ? 19.612  -6.036  13.449 1.00 82.15  ? 357 VAL A CB  1 ? 
ATOM   2209 C CG1 . VAL A 1 325 ? 19.392  -4.821  12.547 1.00 81.32  ? 357 VAL A CG1 1 ? 
ATOM   2210 C CG2 . VAL A 1 325 ? 20.563  -5.690  14.596 1.00 70.98  ? 357 VAL A CG2 1 ? 
ATOM   2211 N N   . HIS A 1 326 ? 17.778  -8.110  15.846 1.00 72.42  ? 358 HIS A N   1 ? 
ATOM   2212 C CA  . HIS A 1 326 ? 17.814  -9.365  16.587 1.00 63.60  ? 358 HIS A CA  1 ? 
ATOM   2213 C C   . HIS A 1 326 ? 17.152  -10.457 15.744 1.00 64.94  ? 358 HIS A C   1 ? 
ATOM   2214 O O   . HIS A 1 326 ? 16.322  -10.164 14.883 1.00 73.71  ? 358 HIS A O   1 ? 
ATOM   2215 C CB  . HIS A 1 326 ? 17.211  -9.133  17.975 1.00 60.27  ? 358 HIS A CB  1 ? 
ATOM   2216 C CG  . HIS A 1 326 ? 17.250  -10.303 18.876 1.00 60.01  ? 358 HIS A CG  1 ? 
ATOM   2217 N ND1 . HIS A 1 326 ? 16.733  -11.536 18.546 1.00 60.83  ? 358 HIS A ND1 1 ? 
ATOM   2218 C CD2 . HIS A 1 326 ? 17.698  -10.399 20.133 1.00 63.54  ? 358 HIS A CD2 1 ? 
ATOM   2219 C CE1 . HIS A 1 326 ? 16.913  -12.362 19.570 1.00 68.02  ? 358 HIS A CE1 1 ? 
ATOM   2220 N NE2 . HIS A 1 326 ? 17.486  -11.687 20.553 1.00 66.19  ? 358 HIS A NE2 1 ? 
ATOM   2221 N N   . ALA A 1 327 ? 17.563  -11.715 15.963 1.00 67.55  ? 359 ALA A N   1 ? 
ATOM   2222 C CA  . ALA A 1 327 ? 17.148  -12.818 15.107 1.00 65.62  ? 359 ALA A CA  1 ? 
ATOM   2223 C C   . ALA A 1 327 ? 15.646  -13.081 15.231 1.00 64.10  ? 359 ALA A C   1 ? 
ATOM   2224 O O   . ALA A 1 327 ? 14.998  -13.466 14.262 1.00 60.43  ? 359 ALA A O   1 ? 
ATOM   2225 C CB  . ALA A 1 327 ? 17.955  -14.057 15.423 1.00 62.50  ? 359 ALA A CB  1 ? 
ATOM   2226 N N   . PHE A 1 328 ? 15.092  -12.887 16.430 1.00 62.08  ? 360 PHE A N   1 ? 
ATOM   2227 C CA  . PHE A 1 328 ? 13.654  -12.946 16.605 1.00 58.41  ? 360 PHE A CA  1 ? 
ATOM   2228 C C   . PHE A 1 328 ? 12.985  -12.041 15.585 1.00 49.93  ? 360 PHE A C   1 ? 
ATOM   2229 O O   . PHE A 1 328 ? 12.174  -12.489 14.796 1.00 55.92  ? 360 PHE A O   1 ? 
ATOM   2230 C CB  . PHE A 1 328 ? 13.185  -12.487 17.982 1.00 58.26  ? 360 PHE A CB  1 ? 
ATOM   2231 C CG  . PHE A 1 328 ? 11.696  -12.688 18.213 1.00 61.04  ? 360 PHE A CG  1 ? 
ATOM   2232 C CD1 . PHE A 1 328 ? 11.094  -13.918 17.958 1.00 66.90  ? 360 PHE A CD1 1 ? 
ATOM   2233 C CD2 . PHE A 1 328 ? 10.901  -11.652 18.688 1.00 61.90  ? 360 PHE A CD2 1 ? 
ATOM   2234 C CE1 . PHE A 1 328 ? 9.740   -14.102 18.177 1.00 61.07  ? 360 PHE A CE1 1 ? 
ATOM   2235 C CE2 . PHE A 1 328 ? 9.550   -11.852 18.917 1.00 62.04  ? 360 PHE A CE2 1 ? 
ATOM   2236 C CZ  . PHE A 1 328 ? 8.974   -13.070 18.654 1.00 56.97  ? 360 PHE A CZ  1 ? 
ATOM   2237 N N   . ILE A 1 329 ? 13.385  -10.775 15.586 1.00 54.74  ? 361 ILE A N   1 ? 
ATOM   2238 C CA  . ILE A 1 329 ? 12.819  -9.801  14.677 1.00 58.28  ? 361 ILE A CA  1 ? 
ATOM   2239 C C   . ILE A 1 329 ? 13.111  -10.168 13.218 1.00 69.52  ? 361 ILE A C   1 ? 
ATOM   2240 O O   . ILE A 1 329 ? 12.233  -10.043 12.365 1.00 68.84  ? 361 ILE A O   1 ? 
ATOM   2241 C CB  . ILE A 1 329 ? 13.300  -8.402  15.078 1.00 58.53  ? 361 ILE A CB  1 ? 
ATOM   2242 C CG1 . ILE A 1 329 ? 12.837  -8.070  16.516 1.00 61.39  ? 361 ILE A CG1 1 ? 
ATOM   2243 C CG2 . ILE A 1 329 ? 12.836  -7.353  14.065 1.00 60.64  ? 361 ILE A CG2 1 ? 
ATOM   2244 C CD1 . ILE A 1 329 ? 11.331  -8.092  16.730 1.00 60.99  ? 361 ILE A CD1 1 ? 
ATOM   2245 N N   . LYS A 1 330 ? 14.323  -10.636 12.908 1.00 70.98  ? 362 LYS A N   1 ? 
ATOM   2246 C CA  . LYS A 1 330 ? 14.628  -10.933 11.517 1.00 78.51  ? 362 LYS A CA  1 ? 
ATOM   2247 C C   . LYS A 1 330 ? 13.730  -12.082 11.066 1.00 65.03  ? 362 LYS A C   1 ? 
ATOM   2248 O O   . LYS A 1 330 ? 13.154  -12.025 9.977  1.00 66.74  ? 362 LYS A O   1 ? 
ATOM   2249 C CB  . LYS A 1 330 ? 16.121  -11.166 11.225 1.00 86.41  ? 362 LYS A CB  1 ? 
ATOM   2250 C CG  . LYS A 1 330 ? 16.962  -9.889  11.182 1.00 93.31  ? 362 LYS A CG  1 ? 
ATOM   2251 C CD  . LYS A 1 330 ? 18.098  -9.858  10.163 1.00 103.14 ? 362 LYS A CD  1 ? 
ATOM   2252 C CE  . LYS A 1 330 ? 19.278  -10.713 10.520 1.00 116.69 ? 362 LYS A CE  1 ? 
ATOM   2253 N NZ  . LYS A 1 330 ? 19.961  -10.288 11.748 1.00 120.87 ? 362 LYS A NZ  1 ? 
ATOM   2254 N N   . ARG A 1 331 ? 13.596  -13.110 11.912 1.00 59.22  ? 363 ARG A N   1 ? 
ATOM   2255 C CA  . ARG A 1 331 ? 12.781  -14.264 11.555 1.00 63.20  ? 363 ARG A CA  1 ? 
ATOM   2256 C C   . ARG A 1 331 ? 11.333  -13.793 11.436 1.00 69.63  ? 363 ARG A C   1 ? 
ATOM   2257 O O   . ARG A 1 331 ? 10.656  -14.065 10.438 1.00 65.85  ? 363 ARG A O   1 ? 
ATOM   2258 C CB  . ARG A 1 331 ? 12.952  -15.442 12.524 1.00 62.17  ? 363 ARG A CB  1 ? 
ATOM   2259 C CG  . ARG A 1 331 ? 11.997  -16.580 12.197 1.00 64.52  ? 363 ARG A CG  1 ? 
ATOM   2260 C CD  . ARG A 1 331 ? 11.986  -17.769 13.132 1.00 64.55  ? 363 ARG A CD  1 ? 
ATOM   2261 N NE  . ARG A 1 331 ? 12.243  -17.506 14.552 1.00 75.11  ? 363 ARG A NE  1 ? 
ATOM   2262 C CZ  . ARG A 1 331 ? 11.352  -17.312 15.521 1.00 76.83  ? 363 ARG A CZ  1 ? 
ATOM   2263 N NH1 . ARG A 1 331 ? 11.699  -17.600 16.764 1.00 77.89  ? 363 ARG A NH1 1 ? 
ATOM   2264 N NH2 . ARG A 1 331 ? 10.111  -16.928 15.255 1.00 73.27  ? 363 ARG A NH2 1 ? 
ATOM   2265 N N   . SER A 1 332 ? 10.902  -13.033 12.450 1.00 67.45  ? 364 SER A N   1 ? 
ATOM   2266 C CA  . SER A 1 332 ? 9.540   -12.539 12.519 1.00 67.81  ? 364 SER A CA  1 ? 
ATOM   2267 C C   . SER A 1 332 ? 9.192   -11.785 11.240 1.00 70.38  ? 364 SER A C   1 ? 
ATOM   2268 O O   . SER A 1 332 ? 8.149   -12.049 10.646 1.00 78.61  ? 364 SER A O   1 ? 
ATOM   2269 C CB  . SER A 1 332 ? 9.316   -11.710 13.755 1.00 66.01  ? 364 SER A CB  1 ? 
ATOM   2270 O OG  . SER A 1 332 ? 9.213   -12.557 14.895 1.00 72.70  ? 364 SER A OG  1 ? 
ATOM   2271 N N   . ASP A 1 333 ? 10.093  -10.906 10.788 1.00 68.47  ? 365 ASP A N   1 ? 
ATOM   2272 C CA  . ASP A 1 333 ? 9.829   -10.057 9.629  1.00 75.06  ? 365 ASP A CA  1 ? 
ATOM   2273 C C   . ASP A 1 333 ? 9.681   -10.880 8.345  1.00 70.33  ? 365 ASP A C   1 ? 
ATOM   2274 O O   . ASP A 1 333 ? 8.948   -10.474 7.451  1.00 81.80  ? 365 ASP A O   1 ? 
ATOM   2275 C CB  . ASP A 1 333 ? 10.910  -9.001  9.458  1.00 85.78  ? 365 ASP A CB  1 ? 
ATOM   2276 C CG  . ASP A 1 333 ? 10.465  -7.659  8.894  1.00 94.40  ? 365 ASP A CG  1 ? 
ATOM   2277 O OD1 . ASP A 1 333 ? 9.764   -7.657  7.858  1.00 98.43  ? 365 ASP A OD1 1 ? 
ATOM   2278 O OD2 . ASP A 1 333 ? 10.849  -6.627  9.493  1.00 97.03  ? 365 ASP A OD2 1 ? 
ATOM   2279 N N   . ALA A 1 334 ? 10.350  -12.039 8.263  1.00 76.83  ? 366 ALA A N   1 ? 
ATOM   2280 C CA  . ALA A 1 334 ? 10.289  -12.904 7.090  1.00 78.86  ? 366 ALA A CA  1 ? 
ATOM   2281 C C   . ALA A 1 334 ? 9.098   -13.862 7.139  1.00 76.26  ? 366 ALA A C   1 ? 
ATOM   2282 O O   . ALA A 1 334 ? 8.738   -14.434 6.115  1.00 83.94  ? 366 ALA A O   1 ? 
ATOM   2283 C CB  . ALA A 1 334 ? 11.573  -13.700 6.960  1.00 74.28  ? 366 ALA A CB  1 ? 
ATOM   2284 N N   . GLU A 1 335 ? 8.526   -14.100 8.323  1.00 68.32  ? 367 GLU A N   1 ? 
ATOM   2285 C CA  . GLU A 1 335 ? 7.415   -15.034 8.431  1.00 74.00  ? 367 GLU A CA  1 ? 
ATOM   2286 C C   . GLU A 1 335 ? 6.174   -14.407 7.793  1.00 70.71  ? 367 GLU A C   1 ? 
ATOM   2287 O O   . GLU A 1 335 ? 5.916   -13.223 7.981  1.00 75.12  ? 367 GLU A O   1 ? 
ATOM   2288 C CB  . GLU A 1 335 ? 7.176   -15.400 9.897  1.00 74.91  ? 367 GLU A CB  1 ? 
ATOM   2289 C CG  . GLU A 1 335 ? 8.147   -16.431 10.472 1.00 71.21  ? 367 GLU A CG  1 ? 
ATOM   2290 C CD  . GLU A 1 335 ? 8.219   -16.460 11.997 1.00 72.31  ? 367 GLU A CD  1 ? 
ATOM   2291 O OE1 . GLU A 1 335 ? 7.731   -15.522 12.677 1.00 67.87  ? 367 GLU A OE1 1 ? 
ATOM   2292 O OE2 . GLU A 1 335 ? 8.784   -17.443 12.521 1.00 77.30  ? 367 GLU A OE2 1 ? 
ATOM   2293 N N   . GLU A 1 336 ? 5.428   -15.198 7.017  1.00 69.52  ? 368 GLU A N   1 ? 
ATOM   2294 C CA  . GLU A 1 336 ? 4.168   -14.756 6.437  1.00 71.03  ? 368 GLU A CA  1 ? 
ATOM   2295 C C   . GLU A 1 336 ? 3.038   -15.262 7.327  1.00 70.91  ? 368 GLU A C   1 ? 
ATOM   2296 O O   . GLU A 1 336 ? 2.566   -16.380 7.157  1.00 80.10  ? 368 GLU A O   1 ? 
ATOM   2297 C CB  . GLU A 1 336 ? 3.970   -15.243 5.002  1.00 79.15  ? 368 GLU A CB  1 ? 
ATOM   2298 C CG  . GLU A 1 336 ? 5.017   -14.713 4.026  1.00 99.41  ? 368 GLU A CG  1 ? 
ATOM   2299 C CD  . GLU A 1 336 ? 4.922   -15.269 2.612  1.00 119.49 ? 368 GLU A CD  1 ? 
ATOM   2300 O OE1 . GLU A 1 336 ? 3.895   -15.897 2.263  1.00 130.69 ? 368 GLU A OE1 1 ? 
ATOM   2301 O OE2 . GLU A 1 336 ? 5.901   -15.082 1.857  1.00 126.47 ? 368 GLU A OE2 1 ? 
ATOM   2302 N N   . VAL A 1 337 ? 2.620   -14.404 8.263  1.00 67.47  ? 369 VAL A N   1 ? 
ATOM   2303 C CA  . VAL A 1 337 ? 1.677   -14.736 9.313  1.00 64.01  ? 369 VAL A CA  1 ? 
ATOM   2304 C C   . VAL A 1 337 ? 0.288   -14.206 8.974  1.00 60.81  ? 369 VAL A C   1 ? 
ATOM   2305 O O   . VAL A 1 337 ? 0.135   -13.041 8.631  1.00 62.17  ? 369 VAL A O   1 ? 
ATOM   2306 C CB  . VAL A 1 337 ? 2.184   -14.078 10.604 1.00 58.85  ? 369 VAL A CB  1 ? 
ATOM   2307 C CG1 . VAL A 1 337 ? 1.162   -14.216 11.722 1.00 62.26  ? 369 VAL A CG1 1 ? 
ATOM   2308 C CG2 . VAL A 1 337 ? 3.535   -14.632 11.016 1.00 56.34  ? 369 VAL A CG2 1 ? 
ATOM   2309 N N   . ASP A 1 338 ? -0.730  -15.043 9.161  1.00 62.29  ? 370 ASP A N   1 ? 
ATOM   2310 C CA  . ASP A 1 338 ? -2.101  -14.651 8.894  1.00 57.83  ? 370 ASP A CA  1 ? 
ATOM   2311 C C   . ASP A 1 338 ? -2.692  -14.101 10.187 1.00 59.14  ? 370 ASP A C   1 ? 
ATOM   2312 O O   . ASP A 1 338 ? -3.496  -14.748 10.849 1.00 60.53  ? 370 ASP A O   1 ? 
ATOM   2313 C CB  . ASP A 1 338 ? -2.873  -15.817 8.309  1.00 57.14  ? 370 ASP A CB  1 ? 
ATOM   2314 C CG  . ASP A 1 338 ? -4.293  -15.477 7.917  1.00 62.62  ? 370 ASP A CG  1 ? 
ATOM   2315 O OD1 . ASP A 1 338 ? -4.653  -14.284 8.071  1.00 62.75  ? 370 ASP A OD1 1 ? 
ATOM   2316 O OD2 . ASP A 1 338 ? -5.001  -16.404 7.464  1.00 69.57  ? 370 ASP A OD2 1 ? 
ATOM   2317 N N   . PHE A 1 339 ? -2.257  -12.889 10.527 1.00 65.76  ? 371 PHE A N   1 ? 
ATOM   2318 C CA  . PHE A 1 339 ? -2.600  -12.245 11.777 1.00 64.30  ? 371 PHE A CA  1 ? 
ATOM   2319 C C   . PHE A 1 339 ? -4.101  -11.945 11.825 1.00 59.70  ? 371 PHE A C   1 ? 
ATOM   2320 O O   . PHE A 1 339 ? -4.726  -12.133 12.859 1.00 62.18  ? 371 PHE A O   1 ? 
ATOM   2321 C CB  . PHE A 1 339 ? -1.717  -11.002 11.903 1.00 58.85  ? 371 PHE A CB  1 ? 
ATOM   2322 C CG  . PHE A 1 339 ? -2.052  -10.155 13.120 1.00 62.54  ? 371 PHE A CG  1 ? 
ATOM   2323 C CD1 . PHE A 1 339 ? -3.128  -9.281  13.099 1.00 68.23  ? 371 PHE A CD1 1 ? 
ATOM   2324 C CD2 . PHE A 1 339 ? -1.310  -10.254 14.283 1.00 63.87  ? 371 PHE A CD2 1 ? 
ATOM   2325 C CE1 . PHE A 1 339 ? -3.460  -8.537  14.215 1.00 74.29  ? 371 PHE A CE1 1 ? 
ATOM   2326 C CE2 . PHE A 1 339 ? -1.635  -9.492  15.389 1.00 67.98  ? 371 PHE A CE2 1 ? 
ATOM   2327 C CZ  . PHE A 1 339 ? -2.709  -8.640  15.356 1.00 75.44  ? 371 PHE A CZ  1 ? 
ATOM   2328 N N   . ALA A 1 340 ? -4.664  -11.463 10.716 1.00 58.39  ? 372 ALA A N   1 ? 
ATOM   2329 C CA  . ALA A 1 340 ? -6.076  -11.111 10.641 1.00 62.67  ? 372 ALA A CA  1 ? 
ATOM   2330 C C   . ALA A 1 340 ? -6.966  -12.316 10.940 1.00 64.12  ? 372 ALA A C   1 ? 
ATOM   2331 O O   . ALA A 1 340 ? -7.949  -12.201 11.676 1.00 73.97  ? 372 ALA A O   1 ? 
ATOM   2332 C CB  . ALA A 1 340 ? -6.404  -10.548 9.279  1.00 56.71  ? 372 ALA A CB  1 ? 
ATOM   2333 N N   . GLY A 1 341 ? -6.610  -13.462 10.353 1.00 62.97  ? 373 GLY A N   1 ? 
ATOM   2334 C CA  . GLY A 1 341 ? -7.377  -14.689 10.505 1.00 67.04  ? 373 GLY A CA  1 ? 
ATOM   2335 C C   . GLY A 1 341 ? -7.275  -15.239 11.923 1.00 60.90  ? 373 GLY A C   1 ? 
ATOM   2336 O O   . GLY A 1 341 ? -8.255  -15.689 12.508 1.00 64.78  ? 373 GLY A O   1 ? 
ATOM   2337 N N   . TRP A 1 342 ? -6.069  -15.202 12.468 1.00 56.92  ? 374 TRP A N   1 ? 
ATOM   2338 C CA  . TRP A 1 342 ? -5.893  -15.547 13.861 1.00 59.78  ? 374 TRP A CA  1 ? 
ATOM   2339 C C   . TRP A 1 342 ? -6.789  -14.639 14.709 1.00 56.34  ? 374 TRP A C   1 ? 
ATOM   2340 O O   . TRP A 1 342 ? -7.453  -15.088 15.636 1.00 52.92  ? 374 TRP A O   1 ? 
ATOM   2341 C CB  . TRP A 1 342 ? -4.408  -15.444 14.265 1.00 55.45  ? 374 TRP A CB  1 ? 
ATOM   2342 C CG  . TRP A 1 342 ? -4.239  -15.703 15.731 1.00 46.99  ? 374 TRP A CG  1 ? 
ATOM   2343 C CD1 . TRP A 1 342 ? -4.170  -16.918 16.337 1.00 45.33  ? 374 TRP A CD1 1 ? 
ATOM   2344 C CD2 . TRP A 1 342 ? -4.265  -14.726 16.788 1.00 40.91  ? 374 TRP A CD2 1 ? 
ATOM   2345 N NE1 . TRP A 1 342 ? -4.126  -16.767 17.700 1.00 49.21  ? 374 TRP A NE1 1 ? 
ATOM   2346 C CE2 . TRP A 1 342 ? -4.176  -15.435 18.004 1.00 45.82  ? 374 TRP A CE2 1 ? 
ATOM   2347 C CE3 . TRP A 1 342 ? -4.323  -13.339 16.818 1.00 47.18  ? 374 TRP A CE3 1 ? 
ATOM   2348 C CZ2 . TRP A 1 342 ? -4.143  -14.798 19.236 1.00 48.98  ? 374 TRP A CZ2 1 ? 
ATOM   2349 C CZ3 . TRP A 1 342 ? -4.285  -12.701 18.036 1.00 47.93  ? 374 TRP A CZ3 1 ? 
ATOM   2350 C CH2 . TRP A 1 342 ? -4.220  -13.421 19.224 1.00 53.50  ? 374 TRP A CH2 1 ? 
ATOM   2351 N N   . LEU A 1 343 ? -6.781  -13.344 14.395 1.00 54.89  ? 375 LEU A N   1 ? 
ATOM   2352 C CA  . LEU A 1 343 ? -7.412  -12.347 15.242 1.00 54.03  ? 375 LEU A CA  1 ? 
ATOM   2353 C C   . LEU A 1 343 ? -8.930  -12.434 15.115 1.00 57.07  ? 375 LEU A C   1 ? 
ATOM   2354 O O   . LEU A 1 343 ? -9.633  -12.364 16.119 1.00 57.19  ? 375 LEU A O   1 ? 
ATOM   2355 C CB  . LEU A 1 343 ? -6.921  -10.947 14.886 1.00 51.72  ? 375 LEU A CB  1 ? 
ATOM   2356 C CG  . LEU A 1 343 ? -7.641  -9.797  15.598 1.00 60.02  ? 375 LEU A CG  1 ? 
ATOM   2357 C CD1 . LEU A 1 343 ? -7.268  -9.705  17.084 1.00 62.03  ? 375 LEU A CD1 1 ? 
ATOM   2358 C CD2 . LEU A 1 343 ? -7.377  -8.487  14.864 1.00 61.67  ? 375 LEU A CD2 1 ? 
ATOM   2359 N N   . CYS A 1 344 ? -9.428  -12.568 13.884 1.00 52.26  ? 376 CYS A N   1 ? 
ATOM   2360 C CA  . CYS A 1 344 ? -10.865 -12.621 13.655 1.00 55.13  ? 376 CYS A CA  1 ? 
ATOM   2361 C C   . CYS A 1 344 ? -11.485 -13.854 14.312 1.00 56.42  ? 376 CYS A C   1 ? 
ATOM   2362 O O   . CYS A 1 344 ? -12.521 -13.744 14.967 1.00 55.09  ? 376 CYS A O   1 ? 
ATOM   2363 C CB  . CYS A 1 344 ? -11.171 -12.518 12.166 1.00 63.01  ? 376 CYS A CB  1 ? 
ATOM   2364 S SG  . CYS A 1 344 ? -10.818 -10.864 11.511 1.00 69.43  ? 376 CYS A SG  1 ? 
ATOM   2365 N N   . SER A 1 345 ? -10.841 -15.016 14.159 1.00 53.53  ? 377 SER A N   1 ? 
ATOM   2366 C CA  . SER A 1 345 ? -11.255 -16.235 14.836 1.00 56.97  ? 377 SER A CA  1 ? 
ATOM   2367 C C   . SER A 1 345 ? -11.249 -16.093 16.360 1.00 57.98  ? 377 SER A C   1 ? 
ATOM   2368 O O   . SER A 1 345 ? -12.156 -16.593 17.024 1.00 62.86  ? 377 SER A O   1 ? 
ATOM   2369 C CB  . SER A 1 345 ? -10.397 -17.379 14.399 1.00 56.68  ? 377 SER A CB  1 ? 
ATOM   2370 O OG  . SER A 1 345 ? -10.417 -17.437 12.981 1.00 57.82  ? 377 SER A OG  1 ? 
ATOM   2371 N N   . THR A 1 346 ? -10.228 -15.429 16.910 1.00 54.69  ? 378 THR A N   1 ? 
ATOM   2372 C CA  . THR A 1 346 ? -10.031 -15.383 18.355 1.00 56.87  ? 378 THR A CA  1 ? 
ATOM   2373 C C   . THR A 1 346 ? -11.169 -14.611 19.031 1.00 56.68  ? 378 THR A C   1 ? 
ATOM   2374 O O   . THR A 1 346 ? -11.640 -14.996 20.103 1.00 58.85  ? 378 THR A O   1 ? 
ATOM   2375 C CB  . THR A 1 346 ? -8.670  -14.756 18.661 1.00 51.30  ? 378 THR A CB  1 ? 
ATOM   2376 O OG1 . THR A 1 346 ? -7.674  -15.574 18.056 1.00 53.09  ? 378 THR A OG1 1 ? 
ATOM   2377 C CG2 . THR A 1 346 ? -8.370  -14.670 20.146 1.00 52.06  ? 378 THR A CG2 1 ? 
ATOM   2378 N N   . ILE A 1 347 ? -11.582 -13.501 18.416 1.00 59.17  ? 379 ILE A N   1 ? 
ATOM   2379 C CA  . ILE A 1 347 ? -12.528 -12.576 19.025 1.00 57.41  ? 379 ILE A CA  1 ? 
ATOM   2380 C C   . ILE A 1 347 ? -13.906 -12.728 18.389 1.00 60.55  ? 379 ILE A C   1 ? 
ATOM   2381 O O   . ILE A 1 347 ? -14.823 -12.004 18.737 1.00 59.36  ? 379 ILE A O   1 ? 
ATOM   2382 C CB  . ILE A 1 347 ? -12.032 -11.127 18.888 1.00 58.68  ? 379 ILE A CB  1 ? 
ATOM   2383 C CG1 . ILE A 1 347 ? -12.015 -10.691 17.445 1.00 60.67  ? 379 ILE A CG1 1 ? 
ATOM   2384 C CG2 . ILE A 1 347 ? -10.670 -10.924 19.557 1.00 57.40  ? 379 ILE A CG2 1 ? 
ATOM   2385 C CD1 . ILE A 1 347 ? -11.615 -9.240  17.261 1.00 64.73  ? 379 ILE A CD1 1 ? 
ATOM   2386 N N   . GLY A 1 348 ? -14.041 -13.638 17.425 1.00 65.87  ? 380 GLY A N   1 ? 
ATOM   2387 C CA  . GLY A 1 348 ? -15.333 -13.933 16.844 1.00 64.34  ? 380 GLY A CA  1 ? 
ATOM   2388 C C   . GLY A 1 348 ? -15.832 -12.780 15.987 1.00 61.43  ? 380 GLY A C   1 ? 
ATOM   2389 O O   . GLY A 1 348 ? -17.023 -12.500 15.948 1.00 79.86  ? 380 GLY A O   1 ? 
ATOM   2390 N N   . LEU A 1 349 ? -14.901 -12.145 15.282 1.00 70.11  ? 381 LEU A N   1 ? 
ATOM   2391 C CA  . LEU A 1 349 ? -15.214 -11.104 14.324 1.00 71.68  ? 381 LEU A CA  1 ? 
ATOM   2392 C C   . LEU A 1 349 ? -15.517 -11.751 12.974 1.00 75.56  ? 381 LEU A C   1 ? 
ATOM   2393 O O   . LEU A 1 349 ? -14.725 -12.549 12.480 1.00 71.50  ? 381 LEU A O   1 ? 
ATOM   2394 C CB  . LEU A 1 349 ? -14.024 -10.151 14.232 1.00 68.28  ? 381 LEU A CB  1 ? 
ATOM   2395 C CG  . LEU A 1 349 ? -14.340 -8.665  14.062 1.00 78.24  ? 381 LEU A CG  1 ? 
ATOM   2396 C CD1 . LEU A 1 349 ? -13.175 -8.006  13.353 1.00 76.08  ? 381 LEU A CD1 1 ? 
ATOM   2397 C CD2 . LEU A 1 349 ? -15.644 -8.406  13.322 1.00 86.37  ? 381 LEU A CD2 1 ? 
ATOM   2398 N N   . ASN A 1 350 ? -16.657 -11.376 12.382 1.00 88.80  ? 382 ASN A N   1 ? 
ATOM   2399 C CA  . ASN A 1 350 ? -17.026 -11.792 11.038 1.00 102.45 ? 382 ASN A CA  1 ? 
ATOM   2400 C C   . ASN A 1 350 ? -16.201 -10.977 10.044 1.00 111.01 ? 382 ASN A C   1 ? 
ATOM   2401 O O   . ASN A 1 350 ? -16.285 -9.750  10.049 1.00 113.11 ? 382 ASN A O   1 ? 
ATOM   2402 C CB  . ASN A 1 350 ? -18.525 -11.625 10.800 1.00 110.96 ? 382 ASN A CB  1 ? 
ATOM   2403 C CG  . ASN A 1 350 ? -19.358 -12.167 11.942 1.00 120.57 ? 382 ASN A CG  1 ? 
ATOM   2404 O OD1 . ASN A 1 350 ? -20.079 -11.405 12.602 1.00 122.72 ? 382 ASN A OD1 1 ? 
ATOM   2405 N ND2 . ASN A 1 350 ? -19.269 -13.466 12.201 1.00 109.72 ? 382 ASN A ND2 1 ? 
ATOM   2406 N N   . GLN A 1 351 ? -15.415 -11.662 9.198  1.00 122.85 ? 383 GLN A N   1 ? 
ATOM   2407 C CA  . GLN A 1 351 ? -14.452 -10.994 8.328  1.00 138.89 ? 383 GLN A CA  1 ? 
ATOM   2408 C C   . GLN A 1 351 ? -15.176 -10.333 7.151  1.00 150.41 ? 383 GLN A C   1 ? 
ATOM   2409 O O   . GLN A 1 351 ? -14.901 -9.170  6.856  1.00 143.23 ? 383 GLN A O   1 ? 
ATOM   2410 C CB  . GLN A 1 351 ? -13.325 -11.907 7.833  1.00 135.24 ? 383 GLN A CB  1 ? 
ATOM   2411 C CG  . GLN A 1 351 ? -12.809 -12.899 8.870  1.00 131.13 ? 383 GLN A CG  1 ? 
ATOM   2412 C CD  . GLN A 1 351 ? -11.596 -13.679 8.405  1.00 128.62 ? 383 GLN A CD  1 ? 
ATOM   2413 O OE1 . GLN A 1 351 ? -10.451 -13.219 8.500  1.00 127.55 ? 383 GLN A OE1 1 ? 
ATOM   2414 N NE2 . GLN A 1 351 ? -11.838 -14.888 7.915  1.00 116.27 ? 383 GLN A NE2 1 ? 
ATOM   2415 N N   . PRO A 1 352 ? -16.081 -11.037 6.420  1.00 164.17 ? 384 PRO A N   1 ? 
ATOM   2416 C CA  . PRO A 1 352 ? -16.968 -10.402 5.444  1.00 164.76 ? 384 PRO A CA  1 ? 
ATOM   2417 C C   . PRO A 1 352 ? -18.372 -10.167 5.999  1.00 158.14 ? 384 PRO A C   1 ? 
ATOM   2418 O O   . PRO A 1 352 ? -18.684 -9.015  6.370  1.00 141.68 ? 384 PRO A O   1 ? 
ATOM   2419 C CB  . PRO A 1 352 ? -16.958 -11.434 4.290  1.00 163.30 ? 384 PRO A CB  1 ? 
ATOM   2420 C CG  . PRO A 1 352 ? -16.456 -12.738 4.911  1.00 159.63 ? 384 PRO A CG  1 ? 
ATOM   2421 C CD  . PRO A 1 352 ? -16.266 -12.495 6.404  1.00 161.05 ? 384 PRO A CD  1 ? 
ATOM   2422 N N   . ASP B 1 11  ? -18.705 -29.008 -2.578 1.00 144.11 ? 43  ASP B N   1 ? 
ATOM   2423 C CA  . ASP B 1 11  ? -17.531 -29.735 -2.015 1.00 133.61 ? 43  ASP B CA  1 ? 
ATOM   2424 C C   . ASP B 1 11  ? -16.793 -30.494 -3.120 1.00 128.92 ? 43  ASP B C   1 ? 
ATOM   2425 O O   . ASP B 1 11  ? -16.350 -31.618 -2.906 1.00 128.34 ? 43  ASP B O   1 ? 
ATOM   2426 C CB  . ASP B 1 11  ? -17.963 -30.674 -0.899 1.00 129.26 ? 43  ASP B CB  1 ? 
ATOM   2427 C CG  . ASP B 1 11  ? -18.823 -31.851 -1.338 1.00 131.66 ? 43  ASP B CG  1 ? 
ATOM   2428 O OD1 . ASP B 1 11  ? -19.249 -31.864 -2.511 1.00 131.65 ? 43  ASP B OD1 1 ? 
ATOM   2429 O OD2 . ASP B 1 11  ? -19.041 -32.760 -0.512 1.00 131.26 ? 43  ASP B OD2 1 ? 
ATOM   2430 N N   . GLU B 1 12  ? -16.662 -29.876 -4.301 1.00 131.02 ? 44  GLU B N   1 ? 
ATOM   2431 C CA  . GLU B 1 12  ? -15.854 -30.423 -5.382 1.00 139.50 ? 44  GLU B CA  1 ? 
ATOM   2432 C C   . GLU B 1 12  ? -14.380 -30.311 -4.985 1.00 136.42 ? 44  GLU B C   1 ? 
ATOM   2433 O O   . GLU B 1 12  ? -13.558 -31.122 -5.407 1.00 128.59 ? 44  GLU B O   1 ? 
ATOM   2434 C CB  . GLU B 1 12  ? -16.223 -29.734 -6.701 1.00 142.11 ? 44  GLU B CB  1 ? 
ATOM   2435 C CG  . GLU B 1 12  ? -15.315 -30.035 -7.895 1.00 145.47 ? 44  GLU B CG  1 ? 
ATOM   2436 C CD  . GLU B 1 12  ? -15.098 -31.490 -8.284 1.00 149.73 ? 44  GLU B CD  1 ? 
ATOM   2437 O OE1 . GLU B 1 12  ? -13.979 -31.806 -8.754 1.00 134.72 ? 44  GLU B OE1 1 ? 
ATOM   2438 O OE2 . GLU B 1 12  ? -16.029 -32.308 -8.112 1.00 150.54 ? 44  GLU B OE2 1 ? 
ATOM   2439 N N   . GLN B 1 13  ? -14.065 -29.308 -4.154 1.00 129.50 ? 45  GLN B N   1 ? 
ATOM   2440 C CA  . GLN B 1 13  ? -12.760 -29.200 -3.521 1.00 125.88 ? 45  GLN B CA  1 ? 
ATOM   2441 C C   . GLN B 1 13  ? -12.495 -30.442 -2.675 1.00 115.00 ? 45  GLN B C   1 ? 
ATOM   2442 O O   . GLN B 1 13  ? -11.403 -31.003 -2.715 1.00 109.97 ? 45  GLN B O   1 ? 
ATOM   2443 C CB  . GLN B 1 13  ? -12.673 -27.958 -2.630 1.00 135.66 ? 45  GLN B CB  1 ? 
ATOM   2444 C CG  . GLN B 1 13  ? -11.426 -27.880 -1.750 1.00 136.01 ? 45  GLN B CG  1 ? 
ATOM   2445 C CD  . GLN B 1 13  ? -10.125 -27.806 -2.524 1.00 139.64 ? 45  GLN B CD  1 ? 
ATOM   2446 O OE1 . GLN B 1 13  ? -9.429  -26.785 -2.500 1.00 139.59 ? 45  GLN B OE1 1 ? 
ATOM   2447 N NE2 . GLN B 1 13  ? -9.761  -28.884 -3.205 1.00 138.14 ? 45  GLN B NE2 1 ? 
ATOM   2448 N N   . GLN B 1 14  ? -13.508 -30.848 -1.907 1.00 105.30 ? 46  GLN B N   1 ? 
ATOM   2449 C CA  . GLN B 1 14  ? -13.402 -31.974 -0.996 1.00 97.47  ? 46  GLN B CA  1 ? 
ATOM   2450 C C   . GLN B 1 14  ? -13.267 -33.295 -1.756 1.00 94.32  ? 46  GLN B C   1 ? 
ATOM   2451 O O   . GLN B 1 14  ? -12.669 -34.239 -1.247 1.00 95.90  ? 46  GLN B O   1 ? 
ATOM   2452 C CB  . GLN B 1 14  ? -14.646 -31.967 -0.110 1.00 97.66  ? 46  GLN B CB  1 ? 
ATOM   2453 C CG  . GLN B 1 14  ? -14.429 -32.507 1.297  1.00 103.22 ? 46  GLN B CG  1 ? 
ATOM   2454 C CD  . GLN B 1 14  ? -15.704 -32.532 2.108  1.00 109.72 ? 46  GLN B CD  1 ? 
ATOM   2455 O OE1 . GLN B 1 14  ? -16.808 -32.385 1.571  1.00 124.33 ? 46  GLN B OE1 1 ? 
ATOM   2456 N NE2 . GLN B 1 14  ? -15.568 -32.731 3.411  1.00 116.33 ? 46  GLN B NE2 1 ? 
ATOM   2457 N N   . ARG B 1 15  ? -13.847 -33.374 -2.961 1.00 107.66 ? 47  ARG B N   1 ? 
ATOM   2458 C CA  . ARG B 1 15  ? -13.889 -34.623 -3.709 1.00 118.75 ? 47  ARG B CA  1 ? 
ATOM   2459 C C   . ARG B 1 15  ? -12.514 -34.898 -4.304 1.00 107.61 ? 47  ARG B C   1 ? 
ATOM   2460 O O   . ARG B 1 15  ? -12.084 -36.047 -4.351 1.00 92.17  ? 47  ARG B O   1 ? 
ATOM   2461 C CB  . ARG B 1 15  ? -14.936 -34.616 -4.831 1.00 137.40 ? 47  ARG B CB  1 ? 
ATOM   2462 C CG  . ARG B 1 15  ? -16.395 -34.692 -4.401 1.00 145.70 ? 47  ARG B CG  1 ? 
ATOM   2463 C CD  . ARG B 1 15  ? -16.813 -36.064 -3.879 1.00 151.55 ? 47  ARG B CD  1 ? 
ATOM   2464 N NE  . ARG B 1 15  ? -16.289 -36.386 -2.545 1.00 161.00 ? 47  ARG B NE  1 ? 
ATOM   2465 C CZ  . ARG B 1 15  ? -16.622 -35.792 -1.396 1.00 167.93 ? 47  ARG B CZ  1 ? 
ATOM   2466 N NH1 . ARG B 1 15  ? -16.088 -36.213 -0.261 1.00 164.57 ? 47  ARG B NH1 1 ? 
ATOM   2467 N NH2 . ARG B 1 15  ? -17.494 -34.796 -1.370 1.00 172.21 ? 47  ARG B NH2 1 ? 
ATOM   2468 N N   . LYS B 1 16  ? -11.859 -33.823 -4.764 1.00 105.45 ? 48  LYS B N   1 ? 
ATOM   2469 C CA  . LYS B 1 16  ? -10.481 -33.862 -5.228 1.00 107.89 ? 48  LYS B CA  1 ? 
ATOM   2470 C C   . LYS B 1 16  ? -9.583  -34.481 -4.158 1.00 117.32 ? 48  LYS B C   1 ? 
ATOM   2471 O O   . LYS B 1 16  ? -8.974  -35.523 -4.393 1.00 124.61 ? 48  LYS B O   1 ? 
ATOM   2472 C CB  . LYS B 1 16  ? -10.023 -32.445 -5.596 1.00 106.87 ? 48  LYS B CB  1 ? 
ATOM   2473 C CG  . LYS B 1 16  ? -10.402 -31.981 -6.997 1.00 114.71 ? 48  LYS B CG  1 ? 
ATOM   2474 C CD  . LYS B 1 16  ? -10.416 -30.466 -7.185 1.00 129.35 ? 48  LYS B CD  1 ? 
ATOM   2475 C CE  . LYS B 1 16  ? -9.146  -29.763 -6.797 1.00 133.19 ? 48  LYS B CE  1 ? 
ATOM   2476 N NZ  . LYS B 1 16  ? -9.282  -28.304 -6.885 1.00 129.02 ? 48  LYS B NZ  1 ? 
ATOM   2477 N N   . ARG B 1 17  ? -9.540  -33.841 -2.980 1.00 115.43 ? 49  ARG B N   1 ? 
ATOM   2478 C CA  . ARG B 1 17  ? -8.671  -34.229 -1.879 1.00 108.60 ? 49  ARG B CA  1 ? 
ATOM   2479 C C   . ARG B 1 17  ? -8.784  -35.724 -1.598 1.00 104.12 ? 49  ARG B C   1 ? 
ATOM   2480 O O   . ARG B 1 17  ? -7.782  -36.368 -1.289 1.00 103.37 ? 49  ARG B O   1 ? 
ATOM   2481 C CB  . ARG B 1 17  ? -9.036  -33.493 -0.584 1.00 117.05 ? 49  ARG B CB  1 ? 
ATOM   2482 C CG  . ARG B 1 17  ? -8.905  -31.978 -0.651 1.00 121.43 ? 49  ARG B CG  1 ? 
ATOM   2483 C CD  . ARG B 1 17  ? -9.959  -31.271 0.201  1.00 132.08 ? 49  ARG B CD  1 ? 
ATOM   2484 N NE  . ARG B 1 17  ? -9.479  -30.489 1.345  1.00 127.52 ? 49  ARG B NE  1 ? 
ATOM   2485 C CZ  . ARG B 1 17  ? -8.767  -29.370 1.251  1.00 126.97 ? 49  ARG B CZ  1 ? 
ATOM   2486 N NH1 . ARG B 1 17  ? -8.682  -28.573 2.299  1.00 134.16 ? 49  ARG B NH1 1 ? 
ATOM   2487 N NH2 . ARG B 1 17  ? -8.213  -29.001 0.105  1.00 123.28 ? 49  ARG B NH2 1 ? 
ATOM   2488 N N   . LEU B 1 18  ? -10.014 -36.250 -1.681 1.00 107.36 ? 50  LEU B N   1 ? 
ATOM   2489 C CA  . LEU B 1 18  ? -10.291 -37.665 -1.470 1.00 114.70 ? 50  LEU B CA  1 ? 
ATOM   2490 C C   . LEU B 1 18  ? -9.680  -38.508 -2.589 1.00 117.52 ? 50  LEU B C   1 ? 
ATOM   2491 O O   . LEU B 1 18  ? -9.084  -39.547 -2.315 1.00 110.25 ? 50  LEU B O   1 ? 
ATOM   2492 C CB  . LEU B 1 18  ? -11.800 -37.890 -1.367 1.00 118.58 ? 50  LEU B CB  1 ? 
ATOM   2493 C CG  . LEU B 1 18  ? -12.415 -37.786 0.033  1.00 130.09 ? 50  LEU B CG  1 ? 
ATOM   2494 C CD1 . LEU B 1 18  ? -12.288 -39.117 0.755  1.00 128.95 ? 50  LEU B CD1 1 ? 
ATOM   2495 C CD2 . LEU B 1 18  ? -11.807 -36.669 0.876  1.00 138.25 ? 50  LEU B CD2 1 ? 
ATOM   2496 N N   . GLU B 1 19  ? -9.849  -38.066 -3.843 1.00 121.54 ? 51  GLU B N   1 ? 
ATOM   2497 C CA  . GLU B 1 19  ? -9.311  -38.775 -4.997 1.00 128.65 ? 51  GLU B CA  1 ? 
ATOM   2498 C C   . GLU B 1 19  ? -7.783  -38.756 -4.943 1.00 115.65 ? 51  GLU B C   1 ? 
ATOM   2499 O O   . GLU B 1 19  ? -7.132  -39.734 -5.311 1.00 106.93 ? 51  GLU B O   1 ? 
ATOM   2500 C CB  . GLU B 1 19  ? -9.795  -38.168 -6.318 1.00 140.48 ? 51  GLU B CB  1 ? 
ATOM   2501 C CG  . GLU B 1 19  ? -11.255 -38.466 -6.660 1.00 144.86 ? 51  GLU B CG  1 ? 
ATOM   2502 C CD  . GLU B 1 19  ? -11.837 -37.605 -7.775 1.00 148.36 ? 51  GLU B CD  1 ? 
ATOM   2503 O OE1 . GLU B 1 19  ? -11.075 -36.820 -8.383 1.00 148.20 ? 51  GLU B OE1 1 ? 
ATOM   2504 O OE2 . GLU B 1 19  ? -13.059 -37.701 -8.030 1.00 141.12 ? 51  GLU B OE2 1 ? 
ATOM   2505 N N   . ALA B 1 20  ? -7.234  -37.626 -4.479 1.00 103.04 ? 52  ALA B N   1 ? 
ATOM   2506 C CA  . ALA B 1 20  ? -5.798  -37.421 -4.381 1.00 103.89 ? 52  ALA B CA  1 ? 
ATOM   2507 C C   . ALA B 1 20  ? -5.169  -38.368 -3.357 1.00 101.30 ? 52  ALA B C   1 ? 
ATOM   2508 O O   . ALA B 1 20  ? -4.061  -38.852 -3.569 1.00 98.73  ? 52  ALA B O   1 ? 
ATOM   2509 C CB  . ALA B 1 20  ? -5.509  -35.976 -4.040 1.00 101.66 ? 52  ALA B CB  1 ? 
ATOM   2510 N N   . PHE B 1 21  ? -5.868  -38.639 -2.250 1.00 94.09  ? 53  PHE B N   1 ? 
ATOM   2511 C CA  . PHE B 1 21  ? -5.308  -39.507 -1.226 1.00 91.34  ? 53  PHE B CA  1 ? 
ATOM   2512 C C   . PHE B 1 21  ? -5.226  -40.939 -1.759 1.00 101.55 ? 53  PHE B C   1 ? 
ATOM   2513 O O   . PHE B 1 21  ? -4.272  -41.647 -1.441 1.00 105.14 ? 53  PHE B O   1 ? 
ATOM   2514 C CB  . PHE B 1 21  ? -6.075  -39.428 0.100  1.00 75.92  ? 53  PHE B CB  1 ? 
ATOM   2515 C CG  . PHE B 1 21  ? -5.368  -40.171 1.224  1.00 75.23  ? 53  PHE B CG  1 ? 
ATOM   2516 C CD1 . PHE B 1 21  ? -4.223  -39.638 1.819  1.00 78.30  ? 53  PHE B CD1 1 ? 
ATOM   2517 C CD2 . PHE B 1 21  ? -5.827  -41.407 1.669  1.00 76.36  ? 53  PHE B CD2 1 ? 
ATOM   2518 C CE1 . PHE B 1 21  ? -3.561  -40.321 2.831  1.00 74.38  ? 53  PHE B CE1 1 ? 
ATOM   2519 C CE2 . PHE B 1 21  ? -5.160  -42.085 2.685  1.00 77.84  ? 53  PHE B CE2 1 ? 
ATOM   2520 C CZ  . PHE B 1 21  ? -4.027  -41.542 3.260  1.00 75.36  ? 53  PHE B CZ  1 ? 
ATOM   2521 N N   . LEU B 1 22  ? -6.219  -41.355 -2.565 1.00 103.64 ? 54  LEU B N   1 ? 
ATOM   2522 C CA  . LEU B 1 22  ? -6.259  -42.698 -3.131 1.00 102.03 ? 54  LEU B CA  1 ? 
ATOM   2523 C C   . LEU B 1 22  ? -5.046  -42.912 -4.030 1.00 91.29  ? 54  LEU B C   1 ? 
ATOM   2524 O O   . LEU B 1 22  ? -4.393  -43.953 -3.954 1.00 75.29  ? 54  LEU B O   1 ? 
ATOM   2525 C CB  . LEU B 1 22  ? -7.546  -42.933 -3.919 1.00 114.76 ? 54  LEU B CB  1 ? 
ATOM   2526 C CG  . LEU B 1 22  ? -8.824  -43.129 -3.101 1.00 127.68 ? 54  LEU B CG  1 ? 
ATOM   2527 C CD1 . LEU B 1 22  ? -9.994  -43.262 -4.064 1.00 131.43 ? 54  LEU B CD1 1 ? 
ATOM   2528 C CD2 . LEU B 1 22  ? -8.750  -44.329 -2.167 1.00 129.51 ? 54  LEU B CD2 1 ? 
ATOM   2529 N N   . THR B 1 23  ? -4.785  -41.917 -4.889 1.00 78.59  ? 55  THR B N   1 ? 
ATOM   2530 C CA  . THR B 1 23  ? -3.587  -41.877 -5.708 1.00 83.23  ? 55  THR B CA  1 ? 
ATOM   2531 C C   . THR B 1 23  ? -2.366  -42.108 -4.823 1.00 87.46  ? 55  THR B C   1 ? 
ATOM   2532 O O   . THR B 1 23  ? -1.511  -42.926 -5.147 1.00 96.51  ? 55  THR B O   1 ? 
ATOM   2533 C CB  . THR B 1 23  ? -3.488  -40.539 -6.442 1.00 89.06  ? 55  THR B CB  1 ? 
ATOM   2534 O OG1 . THR B 1 23  ? -4.713  -40.314 -7.132 1.00 86.15  ? 55  THR B OG1 1 ? 
ATOM   2535 C CG2 . THR B 1 23  ? -2.357  -40.522 -7.453 1.00 97.90  ? 55  THR B CG2 1 ? 
ATOM   2536 N N   . GLN B 1 24  ? -2.292  -41.389 -3.699 1.00 90.93  ? 56  GLN B N   1 ? 
ATOM   2537 C CA  . GLN B 1 24  ? -1.141  -41.503 -2.821 1.00 93.55  ? 56  GLN B CA  1 ? 
ATOM   2538 C C   . GLN B 1 24  ? -1.071  -42.910 -2.240 1.00 82.63  ? 56  GLN B C   1 ? 
ATOM   2539 O O   . GLN B 1 24  ? 0.010   -43.467 -2.088 1.00 87.64  ? 56  GLN B O   1 ? 
ATOM   2540 C CB  . GLN B 1 24  ? -1.144  -40.506 -1.661 1.00 98.38  ? 56  GLN B CB  1 ? 
ATOM   2541 C CG  . GLN B 1 24  ? -0.958  -39.051 -2.072 1.00 103.50 ? 56  GLN B CG  1 ? 
ATOM   2542 C CD  . GLN B 1 24  ? 0.147   -38.848 -3.086 1.00 113.89 ? 56  GLN B CD  1 ? 
ATOM   2543 O OE1 . GLN B 1 24  ? -0.019  -39.125 -4.280 1.00 122.02 ? 56  GLN B OE1 1 ? 
ATOM   2544 N NE2 . GLN B 1 24  ? 1.280   -38.334 -2.629 1.00 118.60 ? 56  GLN B NE2 1 ? 
ATOM   2545 N N   . LYS B 1 25  ? -2.226  -43.475 -1.899 1.00 83.60  ? 57  LYS B N   1 ? 
ATOM   2546 C CA  . LYS B 1 25  ? -2.248  -44.744 -1.193 1.00 89.53  ? 57  LYS B CA  1 ? 
ATOM   2547 C C   . LYS B 1 25  ? -1.909  -45.890 -2.152 1.00 85.93  ? 57  LYS B C   1 ? 
ATOM   2548 O O   . LYS B 1 25  ? -1.449  -46.941 -1.709 1.00 75.54  ? 57  LYS B O   1 ? 
ATOM   2549 C CB  . LYS B 1 25  ? -3.588  -44.873 -0.463 1.00 89.72  ? 57  LYS B CB  1 ? 
ATOM   2550 C CG  . LYS B 1 25  ? -3.797  -46.187 0.272  1.00 95.60  ? 57  LYS B CG  1 ? 
ATOM   2551 C CD  . LYS B 1 25  ? -4.556  -46.041 1.585  1.00 95.98  ? 57  LYS B CD  1 ? 
ATOM   2552 C CE  . LYS B 1 25  ? -5.978  -45.613 1.462  1.00 95.61  ? 57  LYS B CE  1 ? 
ATOM   2553 N NZ  . LYS B 1 25  ? -6.890  -46.757 1.406  1.00 109.42 ? 57  LYS B NZ  1 ? 
ATOM   2554 N N   . GLN B 1 26  ? -2.094  -45.671 -3.464 1.00 89.91  ? 58  GLN B N   1 ? 
ATOM   2555 C CA  . GLN B 1 26  ? -1.822  -46.691 -4.470 1.00 96.28  ? 58  GLN B CA  1 ? 
ATOM   2556 C C   . GLN B 1 26  ? -0.311  -46.876 -4.644 1.00 90.44  ? 58  GLN B C   1 ? 
ATOM   2557 O O   . GLN B 1 26  ? 0.138   -47.890 -5.184 1.00 88.04  ? 58  GLN B O   1 ? 
ATOM   2558 C CB  . GLN B 1 26  ? -2.543  -46.337 -5.776 1.00 104.57 ? 58  GLN B CB  1 ? 
ATOM   2559 C CG  . GLN B 1 26  ? -4.052  -46.589 -5.750 1.00 111.23 ? 58  GLN B CG  1 ? 
ATOM   2560 C CD  . GLN B 1 26  ? -4.832  -45.901 -6.856 1.00 117.72 ? 58  GLN B CD  1 ? 
ATOM   2561 O OE1 . GLN B 1 26  ? -6.070  -45.901 -6.863 1.00 110.94 ? 58  GLN B OE1 1 ? 
ATOM   2562 N NE2 . GLN B 1 26  ? -4.131  -45.293 -7.804 1.00 118.14 ? 58  GLN B NE2 1 ? 
ATOM   2563 N N   . LYS B 1 27  ? 0.461   -45.900 -4.150 1.00 80.01  ? 59  LYS B N   1 ? 
ATOM   2564 C CA  . LYS B 1 27  ? 1.907   -45.869 -4.290 1.00 76.07  ? 59  LYS B CA  1 ? 
ATOM   2565 C C   . LYS B 1 27  ? 2.590   -46.631 -3.157 1.00 73.39  ? 59  LYS B C   1 ? 
ATOM   2566 O O   . LYS B 1 27  ? 3.803   -46.788 -3.177 1.00 79.78  ? 59  LYS B O   1 ? 
ATOM   2567 C CB  . LYS B 1 27  ? 2.397   -44.412 -4.331 1.00 80.22  ? 59  LYS B CB  1 ? 
ATOM   2568 C CG  . LYS B 1 27  ? 1.970   -43.646 -5.592 1.00 89.51  ? 59  LYS B CG  1 ? 
ATOM   2569 C CD  . LYS B 1 27  ? 1.915   -42.123 -5.523 1.00 92.97  ? 59  LYS B CD  1 ? 
ATOM   2570 C CE  . LYS B 1 27  ? 3.248   -41.465 -5.610 1.00 100.14 ? 59  LYS B CE  1 ? 
ATOM   2571 N NZ  . LYS B 1 27  ? 3.126   -40.007 -5.693 1.00 100.05 ? 59  LYS B NZ  1 ? 
ATOM   2572 N N   . VAL B 1 28  ? 1.834   -47.124 -2.176 1.00 76.58  ? 60  VAL B N   1 ? 
ATOM   2573 C CA  . VAL B 1 28  ? 2.464   -47.536 -0.936 1.00 81.81  ? 60  VAL B CA  1 ? 
ATOM   2574 C C   . VAL B 1 28  ? 3.194   -48.851 -1.178 1.00 87.21  ? 60  VAL B C   1 ? 
ATOM   2575 O O   . VAL B 1 28  ? 4.406   -48.840 -1.407 1.00 114.10 ? 60  VAL B O   1 ? 
ATOM   2576 C CB  . VAL B 1 28  ? 1.489   -47.560 0.257  1.00 84.42  ? 60  VAL B CB  1 ? 
ATOM   2577 C CG1 . VAL B 1 28  ? 2.113   -48.139 1.523  1.00 83.01  ? 60  VAL B CG1 1 ? 
ATOM   2578 C CG2 . VAL B 1 28  ? 0.972   -46.153 0.523  1.00 84.20  ? 60  VAL B CG2 1 ? 
ATOM   2579 N N   . GLY B 1 29  ? 2.485   -49.977 -1.132 1.00 74.57  ? 61  GLY B N   1 ? 
ATOM   2580 C CA  . GLY B 1 29  ? 3.163   -51.244 -1.348 1.00 71.88  ? 61  GLY B CA  1 ? 
ATOM   2581 C C   . GLY B 1 29  ? 3.677   -51.854 -0.049 1.00 72.52  ? 61  GLY B C   1 ? 
ATOM   2582 O O   . GLY B 1 29  ? 3.202   -51.536 1.039  1.00 87.39  ? 61  GLY B O   1 ? 
ATOM   2583 N N   . GLU B 1 30  ? 4.632   -52.773 -0.199 1.00 74.54  ? 62  GLU B N   1 ? 
ATOM   2584 C CA  . GLU B 1 30  ? 5.131   -53.571 0.902  1.00 75.82  ? 62  GLU B CA  1 ? 
ATOM   2585 C C   . GLU B 1 30  ? 5.984   -52.665 1.771  1.00 77.86  ? 62  GLU B C   1 ? 
ATOM   2586 O O   . GLU B 1 30  ? 6.874   -51.995 1.255  1.00 83.81  ? 62  GLU B O   1 ? 
ATOM   2587 C CB  . GLU B 1 30  ? 5.984   -54.743 0.420  1.00 79.87  ? 62  GLU B CB  1 ? 
ATOM   2588 C CG  . GLU B 1 30  ? 6.755   -55.416 1.553  1.00 80.98  ? 62  GLU B CG  1 ? 
ATOM   2589 C CD  . GLU B 1 30  ? 7.751   -56.465 1.094  1.00 89.55  ? 62  GLU B CD  1 ? 
ATOM   2590 O OE1 . GLU B 1 30  ? 7.689   -57.548 1.704  1.00 105.15 ? 62  GLU B OE1 1 ? 
ATOM   2591 O OE2 . GLU B 1 30  ? 8.569   -56.228 0.163  1.00 80.27  ? 62  GLU B OE2 1 ? 
ATOM   2592 N N   . LEU B 1 31  ? 5.706   -52.675 3.078  1.00 81.54  ? 63  LEU B N   1 ? 
ATOM   2593 C CA  . LEU B 1 31  ? 6.337   -51.745 3.999  1.00 84.88  ? 63  LEU B CA  1 ? 
ATOM   2594 C C   . LEU B 1 31  ? 7.411   -52.472 4.797  1.00 78.22  ? 63  LEU B C   1 ? 
ATOM   2595 O O   . LEU B 1 31  ? 7.120   -53.445 5.485  1.00 72.53  ? 63  LEU B O   1 ? 
ATOM   2596 C CB  . LEU B 1 31  ? 5.294   -51.107 4.917  1.00 81.71  ? 63  LEU B CB  1 ? 
ATOM   2597 C CG  . LEU B 1 31  ? 4.306   -50.142 4.254  1.00 78.61  ? 63  LEU B CG  1 ? 
ATOM   2598 C CD1 . LEU B 1 31  ? 3.353   -49.553 5.276  1.00 73.94  ? 63  LEU B CD1 1 ? 
ATOM   2599 C CD2 . LEU B 1 31  ? 5.029   -49.037 3.518  1.00 84.63  ? 63  LEU B CD2 1 ? 
ATOM   2600 N N   . LYS B 1 32  ? 8.644   -51.965 4.701  1.00 81.97  ? 64  LYS B N   1 ? 
ATOM   2601 C CA  . LYS B 1 32  ? 9.761   -52.496 5.463  1.00 93.34  ? 64  LYS B CA  1 ? 
ATOM   2602 C C   . LYS B 1 32  ? 10.413  -51.389 6.292  1.00 89.01  ? 64  LYS B C   1 ? 
ATOM   2603 O O   . LYS B 1 32  ? 10.607  -50.265 5.821  1.00 77.07  ? 64  LYS B O   1 ? 
ATOM   2604 C CB  . LYS B 1 32  ? 10.786  -53.113 4.507  1.00 101.74 ? 64  LYS B CB  1 ? 
ATOM   2605 C CG  . LYS B 1 32  ? 10.473  -54.493 3.948  1.00 105.75 ? 64  LYS B CG  1 ? 
ATOM   2606 C CD  . LYS B 1 32  ? 10.967  -54.636 2.511  1.00 122.44 ? 64  LYS B CD  1 ? 
ATOM   2607 C CE  . LYS B 1 32  ? 12.395  -54.209 2.274  1.00 131.54 ? 64  LYS B CE  1 ? 
ATOM   2608 N NZ  . LYS B 1 32  ? 12.616  -53.816 0.879  1.00 135.19 ? 64  LYS B NZ  1 ? 
ATOM   2609 N N   . ASP B 1 33  ? 10.787  -51.768 7.519  1.00 81.65  ? 65  ASP B N   1 ? 
ATOM   2610 C CA  . ASP B 1 33  ? 11.442  -50.916 8.497  1.00 80.45  ? 65  ASP B CA  1 ? 
ATOM   2611 C C   . ASP B 1 33  ? 12.520  -50.041 7.861  1.00 85.14  ? 65  ASP B C   1 ? 
ATOM   2612 O O   . ASP B 1 33  ? 12.606  -48.852 8.159  1.00 106.59 ? 65  ASP B O   1 ? 
ATOM   2613 C CB  . ASP B 1 33  ? 12.078  -51.762 9.590  1.00 83.56  ? 65  ASP B CB  1 ? 
ATOM   2614 C CG  . ASP B 1 33  ? 12.205  -51.088 10.946 1.00 97.30  ? 65  ASP B CG  1 ? 
ATOM   2615 O OD1 . ASP B 1 33  ? 12.757  -49.961 10.998 1.00 96.75  ? 65  ASP B OD1 1 ? 
ATOM   2616 O OD2 . ASP B 1 33  ? 11.740  -51.694 11.936 1.00 98.27  ? 65  ASP B OD2 1 ? 
ATOM   2617 N N   . ASP B 1 34  ? 13.348  -50.634 6.998  1.00 85.26  ? 66  ASP B N   1 ? 
ATOM   2618 C CA  . ASP B 1 34  ? 14.532  -49.972 6.468  1.00 91.00  ? 66  ASP B CA  1 ? 
ATOM   2619 C C   . ASP B 1 34  ? 14.213  -49.042 5.292  1.00 82.15  ? 66  ASP B C   1 ? 
ATOM   2620 O O   . ASP B 1 34  ? 15.124  -48.453 4.714  1.00 81.40  ? 66  ASP B O   1 ? 
ATOM   2621 C CB  . ASP B 1 34  ? 15.590  -50.992 6.073  1.00 100.05 ? 66  ASP B CB  1 ? 
ATOM   2622 C CG  . ASP B 1 34  ? 15.070  -52.174 5.266  1.00 113.45 ? 66  ASP B CG  1 ? 
ATOM   2623 O OD1 . ASP B 1 34  ? 14.324  -52.993 5.853  1.00 113.74 ? 66  ASP B OD1 1 ? 
ATOM   2624 O OD2 . ASP B 1 34  ? 15.387  -52.249 4.055  1.00 121.80 ? 66  ASP B OD2 1 ? 
ATOM   2625 N N   . ASP B 1 35  ? 12.940  -48.881 4.918  1.00 83.68  ? 67  ASP B N   1 ? 
ATOM   2626 C CA  . ASP B 1 35  ? 12.622  -47.967 3.830  1.00 83.19  ? 67  ASP B CA  1 ? 
ATOM   2627 C C   . ASP B 1 35  ? 12.251  -46.594 4.382  1.00 78.28  ? 67  ASP B C   1 ? 
ATOM   2628 O O   . ASP B 1 35  ? 11.883  -45.698 3.619  1.00 76.77  ? 67  ASP B O   1 ? 
ATOM   2629 C CB  . ASP B 1 35  ? 11.591  -48.558 2.882  1.00 81.23  ? 67  ASP B CB  1 ? 
ATOM   2630 C CG  . ASP B 1 35  ? 12.114  -49.711 2.039  1.00 83.55  ? 67  ASP B CG  1 ? 
ATOM   2631 O OD1 . ASP B 1 35  ? 13.253  -49.586 1.543  1.00 76.68  ? 67  ASP B OD1 1 ? 
ATOM   2632 O OD2 . ASP B 1 35  ? 11.387  -50.719 1.889  1.00 85.22  ? 67  ASP B OD2 1 ? 
ATOM   2633 N N   . PHE B 1 36  ? 12.403  -46.433 5.701  1.00 74.66  ? 68  PHE B N   1 ? 
ATOM   2634 C CA  . PHE B 1 36  ? 11.882  -45.274 6.400  1.00 84.81  ? 68  PHE B CA  1 ? 
ATOM   2635 C C   . PHE B 1 36  ? 13.028  -44.487 7.023  1.00 91.21  ? 68  PHE B C   1 ? 
ATOM   2636 O O   . PHE B 1 36  ? 13.809  -45.038 7.797  1.00 88.81  ? 68  PHE B O   1 ? 
ATOM   2637 C CB  . PHE B 1 36  ? 10.898  -45.674 7.504  1.00 90.04  ? 68  PHE B CB  1 ? 
ATOM   2638 C CG  . PHE B 1 36  ? 9.535   -46.165 7.034  1.00 88.84  ? 68  PHE B CG  1 ? 
ATOM   2639 C CD1 . PHE B 1 36  ? 8.613   -45.283 6.479  1.00 94.05  ? 68  PHE B CD1 1 ? 
ATOM   2640 C CD2 . PHE B 1 36  ? 9.163   -47.494 7.191  1.00 82.75  ? 68  PHE B CD2 1 ? 
ATOM   2641 C CE1 . PHE B 1 36  ? 7.362   -45.724 6.077  1.00 94.48  ? 68  PHE B CE1 1 ? 
ATOM   2642 C CE2 . PHE B 1 36  ? 7.912   -47.929 6.788  1.00 92.40  ? 68  PHE B CE2 1 ? 
ATOM   2643 C CZ  . PHE B 1 36  ? 7.015   -47.045 6.233  1.00 95.65  ? 68  PHE B CZ  1 ? 
ATOM   2644 N N   . GLU B 1 37  ? 13.067  -43.192 6.688  1.00 93.19  ? 69  GLU B N   1 ? 
ATOM   2645 C CA  . GLU B 1 37  ? 13.957  -42.221 7.302  1.00 96.03  ? 69  GLU B CA  1 ? 
ATOM   2646 C C   . GLU B 1 37  ? 13.189  -41.416 8.355  1.00 96.10  ? 69  GLU B C   1 ? 
ATOM   2647 O O   . GLU B 1 37  ? 12.276  -40.661 8.013  1.00 81.56  ? 69  GLU B O   1 ? 
ATOM   2648 C CB  . GLU B 1 37  ? 14.453  -41.353 6.145  1.00 106.86 ? 69  GLU B CB  1 ? 
ATOM   2649 C CG  . GLU B 1 37  ? 15.577  -40.394 6.523  1.00 128.72 ? 69  GLU B CG  1 ? 
ATOM   2650 C CD  . GLU B 1 37  ? 16.081  -39.545 5.368  1.00 141.77 ? 69  GLU B CD  1 ? 
ATOM   2651 O OE1 . GLU B 1 37  ? 16.225  -38.318 5.558  1.00 149.37 ? 69  GLU B OE1 1 ? 
ATOM   2652 O OE2 . GLU B 1 37  ? 16.323  -40.108 4.276  1.00 151.96 ? 69  GLU B OE2 1 ? 
ATOM   2653 N N   . LYS B 1 38  ? 13.558  -41.578 9.635  1.00 99.49  ? 70  LYS B N   1 ? 
ATOM   2654 C CA  . LYS B 1 38  ? 12.937  -40.822 10.720 1.00 104.76 ? 70  LYS B CA  1 ? 
ATOM   2655 C C   . LYS B 1 38  ? 13.266  -39.342 10.536 1.00 111.04 ? 70  LYS B C   1 ? 
ATOM   2656 O O   . LYS B 1 38  ? 14.408  -39.004 10.235 1.00 118.37 ? 70  LYS B O   1 ? 
ATOM   2657 C CB  . LYS B 1 38  ? 13.371  -41.231 12.136 1.00 99.03  ? 70  LYS B CB  1 ? 
ATOM   2658 C CG  . LYS B 1 38  ? 13.151  -42.700 12.504 1.00 122.32 ? 70  LYS B CG  1 ? 
ATOM   2659 C CD  . LYS B 1 38  ? 14.299  -43.651 12.164 1.00 135.25 ? 70  LYS B CD  1 ? 
ATOM   2660 C CE  . LYS B 1 38  ? 13.904  -45.103 12.089 1.00 142.13 ? 70  LYS B CE  1 ? 
ATOM   2661 N NZ  . LYS B 1 38  ? 13.120  -45.435 10.893 1.00 145.35 ? 70  LYS B NZ  1 ? 
ATOM   2662 N N   . ILE B 1 39  ? 12.255  -38.472 10.686 1.00 116.22 ? 71  ILE B N   1 ? 
ATOM   2663 C CA  . ILE B 1 39  ? 12.454  -37.037 10.529 1.00 112.45 ? 71  ILE B CA  1 ? 
ATOM   2664 C C   . ILE B 1 39  ? 12.436  -36.375 11.902 1.00 110.44 ? 71  ILE B C   1 ? 
ATOM   2665 O O   . ILE B 1 39  ? 13.322  -35.583 12.215 1.00 131.45 ? 71  ILE B O   1 ? 
ATOM   2666 C CB  . ILE B 1 39  ? 11.418  -36.391 9.590  1.00 104.34 ? 71  ILE B CB  1 ? 
ATOM   2667 C CG1 . ILE B 1 39  ? 11.165  -37.256 8.348  1.00 101.56 ? 71  ILE B CG1 1 ? 
ATOM   2668 C CG2 . ILE B 1 39  ? 11.851  -34.963 9.241  1.00 104.48 ? 71  ILE B CG2 1 ? 
ATOM   2669 C CD1 . ILE B 1 39  ? 10.482  -36.546 7.189  1.00 101.81 ? 71  ILE B CD1 1 ? 
ATOM   2670 N N   . SER B 1 40  ? 11.414  -36.691 12.700 1.00 98.58  ? 72  SER B N   1 ? 
ATOM   2671 C CA  . SER B 1 40  ? 11.252  -36.076 14.004 1.00 102.32 ? 72  SER B CA  1 ? 
ATOM   2672 C C   . SER B 1 40  ? 10.307  -36.918 14.851 1.00 101.14 ? 72  SER B C   1 ? 
ATOM   2673 O O   . SER B 1 40  ? 9.922   -38.020 14.458 1.00 109.04 ? 72  SER B O   1 ? 
ATOM   2674 C CB  . SER B 1 40  ? 10.760  -34.647 13.876 1.00 109.26 ? 72  SER B CB  1 ? 
ATOM   2675 O OG  . SER B 1 40  ? 9.372   -34.590 13.584 1.00 115.47 ? 72  SER B OG  1 ? 
ATOM   2676 N N   . GLU B 1 41  ? 9.955   -36.383 16.021 1.00 97.29  ? 73  GLU B N   1 ? 
ATOM   2677 C CA  . GLU B 1 41  ? 9.018   -37.037 16.917 1.00 111.90 ? 73  GLU B CA  1 ? 
ATOM   2678 C C   . GLU B 1 41  ? 7.792   -36.135 17.009 1.00 109.59 ? 73  GLU B C   1 ? 
ATOM   2679 O O   . GLU B 1 41  ? 7.842   -34.987 16.571 1.00 122.92 ? 73  GLU B O   1 ? 
ATOM   2680 C CB  . GLU B 1 41  ? 9.736   -37.322 18.238 1.00 119.77 ? 73  GLU B CB  1 ? 
ATOM   2681 C CG  . GLU B 1 41  ? 9.111   -38.446 19.060 1.00 127.05 ? 73  GLU B CG  1 ? 
ATOM   2682 C CD  . GLU B 1 41  ? 10.007  -39.052 20.133 1.00 136.20 ? 73  GLU B CD  1 ? 
ATOM   2683 O OE1 . GLU B 1 41  ? 11.183  -38.640 20.275 1.00 127.40 ? 73  GLU B OE1 1 ? 
ATOM   2684 O OE2 . GLU B 1 41  ? 9.514   -39.961 20.836 1.00 142.33 ? 73  GLU B OE2 1 ? 
ATOM   2685 N N   . LEU B 1 42  ? 6.683   -36.680 17.520 1.00 98.88  ? 74  LEU B N   1 ? 
ATOM   2686 C CA  . LEU B 1 42  ? 5.442   -35.928 17.626 1.00 108.14 ? 74  LEU B CA  1 ? 
ATOM   2687 C C   . LEU B 1 42  ? 4.393   -36.780 18.334 1.00 123.80 ? 74  LEU B C   1 ? 
ATOM   2688 O O   . LEU B 1 42  ? 3.941   -37.795 17.807 1.00 125.34 ? 74  LEU B O   1 ? 
ATOM   2689 C CB  . LEU B 1 42  ? 4.936   -35.409 16.277 1.00 105.18 ? 74  LEU B CB  1 ? 
ATOM   2690 C CG  . LEU B 1 42  ? 5.223   -36.238 15.019 1.00 90.99  ? 74  LEU B CG  1 ? 
ATOM   2691 C CD1 . LEU B 1 42  ? 4.156   -37.262 14.660 1.00 88.78  ? 74  LEU B CD1 1 ? 
ATOM   2692 C CD2 . LEU B 1 42  ? 5.441   -35.266 13.871 1.00 90.19  ? 74  LEU B CD2 1 ? 
ATOM   2693 N N   . GLY B 1 43  ? 4.011   -36.341 19.538 1.00 135.96 ? 75  GLY B N   1 ? 
ATOM   2694 C CA  . GLY B 1 43  ? 3.128   -37.114 20.392 1.00 140.96 ? 75  GLY B CA  1 ? 
ATOM   2695 C C   . GLY B 1 43  ? 3.818   -38.366 20.935 1.00 151.26 ? 75  GLY B C   1 ? 
ATOM   2696 O O   . GLY B 1 43  ? 4.929   -38.718 20.526 1.00 126.29 ? 75  GLY B O   1 ? 
ATOM   2697 N N   . ALA B 1 44  ? 3.131   -39.017 21.882 1.00 165.69 ? 76  ALA B N   1 ? 
ATOM   2698 C CA  . ALA B 1 44  ? 3.537   -40.313 22.404 1.00 169.32 ? 76  ALA B CA  1 ? 
ATOM   2699 C C   . ALA B 1 44  ? 2.431   -40.927 23.268 1.00 173.53 ? 76  ALA B C   1 ? 
ATOM   2700 O O   . ALA B 1 44  ? 2.698   -41.825 24.065 1.00 172.50 ? 76  ALA B O   1 ? 
ATOM   2701 C CB  . ALA B 1 44  ? 4.828   -40.162 23.185 1.00 162.57 ? 76  ALA B CB  1 ? 
ATOM   2702 N N   . GLY B 1 45  ? 1.185   -40.466 23.085 1.00 174.14 ? 77  GLY B N   1 ? 
ATOM   2703 C CA  . GLY B 1 45  ? 0.088   -40.833 23.965 1.00 171.70 ? 77  GLY B CA  1 ? 
ATOM   2704 C C   . GLY B 1 45  ? -0.528  -42.175 23.574 1.00 172.49 ? 77  GLY B C   1 ? 
ATOM   2705 O O   . GLY B 1 45  ? -0.132  -42.779 22.578 1.00 159.98 ? 77  GLY B O   1 ? 
ATOM   2706 N N   . ASN B 1 46  ? -1.502  -42.616 24.384 1.00 176.47 ? 78  ASN B N   1 ? 
ATOM   2707 C CA  . ASN B 1 46  ? -2.226  -43.865 24.188 1.00 174.47 ? 78  ASN B CA  1 ? 
ATOM   2708 C C   . ASN B 1 46  ? -1.264  -45.038 24.415 1.00 169.97 ? 78  ASN B C   1 ? 
ATOM   2709 O O   . ASN B 1 46  ? -0.733  -45.184 25.512 1.00 159.05 ? 78  ASN B O   1 ? 
ATOM   2710 C CB  . ASN B 1 46  ? -3.003  -43.854 22.871 1.00 176.95 ? 78  ASN B CB  1 ? 
ATOM   2711 C CG  . ASN B 1 46  ? -4.061  -42.773 22.800 1.00 174.92 ? 78  ASN B CG  1 ? 
ATOM   2712 O OD1 . ASN B 1 46  ? -4.156  -41.916 23.686 1.00 157.58 ? 78  ASN B OD1 1 ? 
ATOM   2713 N ND2 . ASN B 1 46  ? -4.859  -42.784 21.741 1.00 175.21 ? 78  ASN B ND2 1 ? 
ATOM   2714 N N   . GLY B 1 47  ? -1.050  -45.878 23.392 1.00 170.46 ? 79  GLY B N   1 ? 
ATOM   2715 C CA  . GLY B 1 47  ? -0.189  -47.046 23.510 1.00 164.16 ? 79  GLY B CA  1 ? 
ATOM   2716 C C   . GLY B 1 47  ? 1.294   -46.676 23.496 1.00 159.39 ? 79  GLY B C   1 ? 
ATOM   2717 O O   . GLY B 1 47  ? 1.900   -46.492 24.551 1.00 150.71 ? 79  GLY B O   1 ? 
ATOM   2718 N N   . GLY B 1 48  ? 1.863   -46.568 22.287 1.00 146.88 ? 80  GLY B N   1 ? 
ATOM   2719 C CA  . GLY B 1 48  ? 3.299   -46.419 22.107 1.00 142.51 ? 80  GLY B CA  1 ? 
ATOM   2720 C C   . GLY B 1 48  ? 3.694   -45.021 21.629 1.00 138.72 ? 80  GLY B C   1 ? 
ATOM   2721 O O   . GLY B 1 48  ? 3.070   -44.029 22.002 1.00 153.01 ? 80  GLY B O   1 ? 
ATOM   2722 N N   . VAL B 1 49  ? 4.748   -44.976 20.803 1.00 120.69 ? 81  VAL B N   1 ? 
ATOM   2723 C CA  . VAL B 1 49  ? 5.390   -43.745 20.364 1.00 109.84 ? 81  VAL B CA  1 ? 
ATOM   2724 C C   . VAL B 1 49  ? 4.911   -43.451 18.944 1.00 99.27  ? 81  VAL B C   1 ? 
ATOM   2725 O O   . VAL B 1 49  ? 4.332   -44.325 18.306 1.00 100.30 ? 81  VAL B O   1 ? 
ATOM   2726 C CB  . VAL B 1 49  ? 6.928   -43.890 20.409 1.00 108.27 ? 81  VAL B CB  1 ? 
ATOM   2727 C CG1 . VAL B 1 49  ? 7.632   -42.545 20.580 1.00 109.21 ? 81  VAL B CG1 1 ? 
ATOM   2728 C CG2 . VAL B 1 49  ? 7.384   -44.863 21.491 1.00 108.53 ? 81  VAL B CG2 1 ? 
ATOM   2729 N N   . VAL B 1 50  ? 5.169   -42.232 18.447 1.00 81.15  ? 82  VAL B N   1 ? 
ATOM   2730 C CA  . VAL B 1 50  ? 4.780   -41.854 17.100 1.00 74.88  ? 82  VAL B CA  1 ? 
ATOM   2731 C C   . VAL B 1 50  ? 5.855   -40.940 16.535 1.00 71.59  ? 82  VAL B C   1 ? 
ATOM   2732 O O   . VAL B 1 50  ? 6.338   -40.060 17.236 1.00 78.18  ? 82  VAL B O   1 ? 
ATOM   2733 C CB  . VAL B 1 50  ? 3.400   -41.170 16.993 1.00 83.34  ? 82  VAL B CB  1 ? 
ATOM   2734 C CG1 . VAL B 1 50  ? 3.082   -40.732 15.565 1.00 90.27  ? 82  VAL B CG1 1 ? 
ATOM   2735 C CG2 . VAL B 1 50  ? 2.277   -42.057 17.505 1.00 86.64  ? 82  VAL B CG2 1 ? 
ATOM   2736 N N   . PHE B 1 51  ? 6.154   -41.132 15.241 1.00 79.58  ? 83  PHE B N   1 ? 
ATOM   2737 C CA  . PHE B 1 51  ? 7.226   -40.443 14.546 1.00 83.46  ? 83  PHE B CA  1 ? 
ATOM   2738 C C   . PHE B 1 51  ? 6.715   -39.935 13.208 1.00 80.98  ? 83  PHE B C   1 ? 
ATOM   2739 O O   . PHE B 1 51  ? 5.889   -40.583 12.563 1.00 82.31  ? 83  PHE B O   1 ? 
ATOM   2740 C CB  . PHE B 1 51  ? 8.387   -41.399 14.248 1.00 93.22  ? 83  PHE B CB  1 ? 
ATOM   2741 C CG  . PHE B 1 51  ? 9.043   -41.994 15.483 1.00 95.91  ? 83  PHE B CG  1 ? 
ATOM   2742 C CD1 . PHE B 1 51  ? 8.460   -43.061 16.154 1.00 104.60 ? 83  PHE B CD1 1 ? 
ATOM   2743 C CD2 . PHE B 1 51  ? 10.239  -41.477 15.973 1.00 107.36 ? 83  PHE B CD2 1 ? 
ATOM   2744 C CE1 . PHE B 1 51  ? 9.054   -43.592 17.290 1.00 110.94 ? 83  PHE B CE1 1 ? 
ATOM   2745 C CE2 . PHE B 1 51  ? 10.829  -42.013 17.106 1.00 111.95 ? 83  PHE B CE2 1 ? 
ATOM   2746 C CZ  . PHE B 1 51  ? 10.235  -43.067 17.764 1.00 111.86 ? 83  PHE B CZ  1 ? 
ATOM   2747 N N   . LYS B 1 52  ? 7.247   -38.790 12.788 1.00 72.96  ? 84  LYS B N   1 ? 
ATOM   2748 C CA  . LYS B 1 52  ? 7.149   -38.383 11.401 1.00 72.30  ? 84  LYS B CA  1 ? 
ATOM   2749 C C   . LYS B 1 52  ? 8.240   -39.123 10.638 1.00 85.66  ? 84  LYS B C   1 ? 
ATOM   2750 O O   . LYS B 1 52  ? 9.360   -39.231 11.137 1.00 92.24  ? 84  LYS B O   1 ? 
ATOM   2751 C CB  . LYS B 1 52  ? 7.352   -36.872 11.264 1.00 65.84  ? 84  LYS B CB  1 ? 
ATOM   2752 C CG  . LYS B 1 52  ? 7.120   -36.353 9.866  1.00 68.56  ? 84  LYS B CG  1 ? 
ATOM   2753 C CD  . LYS B 1 52  ? 6.812   -34.865 9.753  1.00 68.67  ? 84  LYS B CD  1 ? 
ATOM   2754 C CE  . LYS B 1 52  ? 7.874   -34.095 9.080  1.00 73.25  ? 84  LYS B CE  1 ? 
ATOM   2755 N NZ  . LYS B 1 52  ? 7.298   -32.892 8.476  1.00 78.65  ? 84  LYS B NZ  1 ? 
ATOM   2756 N N   . VAL B 1 53  ? 7.906   -39.637 9.444  1.00 93.98  ? 85  VAL B N   1 ? 
ATOM   2757 C CA  . VAL B 1 53  ? 8.835   -40.439 8.660  1.00 85.12  ? 85  VAL B CA  1 ? 
ATOM   2758 C C   . VAL B 1 53  ? 8.650   -40.147 7.175  1.00 85.91  ? 85  VAL B C   1 ? 
ATOM   2759 O O   . VAL B 1 53  ? 7.572   -39.755 6.738  1.00 87.80  ? 85  VAL B O   1 ? 
ATOM   2760 C CB  . VAL B 1 53  ? 8.668   -41.942 8.934  1.00 74.72  ? 85  VAL B CB  1 ? 
ATOM   2761 C CG1 . VAL B 1 53  ? 8.963   -42.296 10.388 1.00 74.06  ? 85  VAL B CG1 1 ? 
ATOM   2762 C CG2 . VAL B 1 53  ? 7.279   -42.423 8.541  1.00 78.93  ? 85  VAL B CG2 1 ? 
ATOM   2763 N N   . SER B 1 54  ? 9.744   -40.316 6.426  1.00 90.95  ? 86  SER B N   1 ? 
ATOM   2764 C CA  . SER B 1 54  ? 9.712   -40.374 4.976  1.00 95.46  ? 86  SER B CA  1 ? 
ATOM   2765 C C   . SER B 1 54  ? 9.783   -41.839 4.563  1.00 91.35  ? 86  SER B C   1 ? 
ATOM   2766 O O   . SER B 1 54  ? 10.457  -42.625 5.223  1.00 86.71  ? 86  SER B O   1 ? 
ATOM   2767 C CB  . SER B 1 54  ? 10.838  -39.573 4.371  1.00 105.24 ? 86  SER B CB  1 ? 
ATOM   2768 O OG  . SER B 1 54  ? 10.769  -39.585 2.951  1.00 114.54 ? 86  SER B OG  1 ? 
ATOM   2769 N N   . HIS B 1 55  ? 9.039   -42.200 3.513  1.00 87.73  ? 87  HIS B N   1 ? 
ATOM   2770 C CA  . HIS B 1 55  ? 9.107   -43.529 2.932  1.00 81.74  ? 87  HIS B CA  1 ? 
ATOM   2771 C C   . HIS B 1 55  ? 9.725   -43.359 1.552  1.00 83.69  ? 87  HIS B C   1 ? 
ATOM   2772 O O   . HIS B 1 55  ? 9.056   -42.879 0.639  1.00 77.84  ? 87  HIS B O   1 ? 
ATOM   2773 C CB  . HIS B 1 55  ? 7.717   -44.172 2.894  1.00 86.57  ? 87  HIS B CB  1 ? 
ATOM   2774 C CG  . HIS B 1 55  ? 7.678   -45.587 2.399  1.00 89.53  ? 87  HIS B CG  1 ? 
ATOM   2775 N ND1 . HIS B 1 55  ? 7.170   -45.928 1.163  1.00 85.36  ? 87  HIS B ND1 1 ? 
ATOM   2776 C CD2 . HIS B 1 55  ? 8.040   -46.748 2.979  1.00 86.54  ? 87  HIS B CD2 1 ? 
ATOM   2777 C CE1 . HIS B 1 55  ? 7.245   -47.246 1.008  1.00 92.72  ? 87  HIS B CE1 1 ? 
ATOM   2778 N NE2 . HIS B 1 55  ? 7.775   -47.763 2.097  1.00 82.88  ? 87  HIS B NE2 1 ? 
ATOM   2779 N N   . LYS B 1 56  ? 11.009  -43.716 1.430  1.00 83.74  ? 88  LYS B N   1 ? 
ATOM   2780 C CA  . LYS B 1 56  ? 11.781  -43.399 0.238  1.00 90.86  ? 88  LYS B CA  1 ? 
ATOM   2781 C C   . LYS B 1 56  ? 11.122  -44.006 -1.002 1.00 82.86  ? 88  LYS B C   1 ? 
ATOM   2782 O O   . LYS B 1 56  ? 10.986  -43.329 -2.024 1.00 75.41  ? 88  LYS B O   1 ? 
ATOM   2783 C CB  . LYS B 1 56  ? 13.244  -43.844 0.362  1.00 98.15  ? 88  LYS B CB  1 ? 
ATOM   2784 C CG  . LYS B 1 56  ? 14.138  -42.904 1.159  1.00 112.99 ? 88  LYS B CG  1 ? 
ATOM   2785 C CD  . LYS B 1 56  ? 14.269  -43.210 2.647  1.00 124.87 ? 88  LYS B CD  1 ? 
ATOM   2786 C CE  . LYS B 1 56  ? 15.424  -44.110 2.984  1.00 131.84 ? 88  LYS B CE  1 ? 
ATOM   2787 N NZ  . LYS B 1 56  ? 15.242  -45.498 2.551  1.00 138.08 ? 88  LYS B NZ  1 ? 
ATOM   2788 N N   . PRO B 1 57  ? 10.680  -45.285 -0.966 1.00 75.12  ? 89  PRO B N   1 ? 
ATOM   2789 C CA  . PRO B 1 57  ? 10.091  -45.910 -2.151 1.00 79.94  ? 89  PRO B CA  1 ? 
ATOM   2790 C C   . PRO B 1 57  ? 8.978   -45.036 -2.719 1.00 79.60  ? 89  PRO B C   1 ? 
ATOM   2791 O O   . PRO B 1 57  ? 9.071   -44.581 -3.859 1.00 81.07  ? 89  PRO B O   1 ? 
ATOM   2792 C CB  . PRO B 1 57  ? 9.595   -47.276 -1.643 1.00 85.93  ? 89  PRO B CB  1 ? 
ATOM   2793 C CG  . PRO B 1 57  ? 10.477  -47.563 -0.432 1.00 82.93  ? 89  PRO B CG  1 ? 
ATOM   2794 C CD  . PRO B 1 57  ? 10.722  -46.198 0.192  1.00 80.81  ? 89  PRO B CD  1 ? 
ATOM   2795 N N   . SER B 1 58  ? 7.976   -44.750 -1.875 1.00 82.75  ? 90  SER B N   1 ? 
ATOM   2796 C CA  . SER B 1 58  ? 6.777   -44.023 -2.277 1.00 75.87  ? 90  SER B CA  1 ? 
ATOM   2797 C C   . SER B 1 58  ? 7.031   -42.522 -2.394 1.00 69.97  ? 90  SER B C   1 ? 
ATOM   2798 O O   . SER B 1 58  ? 6.330   -41.849 -3.144 1.00 80.28  ? 90  SER B O   1 ? 
ATOM   2799 C CB  . SER B 1 58  ? 5.628   -44.304 -1.334 1.00 75.28  ? 90  SER B CB  1 ? 
ATOM   2800 O OG  . SER B 1 58  ? 5.950   -43.975 0.010  1.00 71.52  ? 90  SER B OG  1 ? 
ATOM   2801 N N   . GLY B 1 59  ? 8.035   -42.002 -1.676 1.00 77.23  ? 91  GLY B N   1 ? 
ATOM   2802 C CA  . GLY B 1 59  ? 8.254   -40.564 -1.598 1.00 83.04  ? 91  GLY B CA  1 ? 
ATOM   2803 C C   . GLY B 1 59  ? 7.175   -39.896 -0.745 1.00 91.62  ? 91  GLY B C   1 ? 
ATOM   2804 O O   . GLY B 1 59  ? 6.831   -38.736 -0.959 1.00 96.63  ? 91  GLY B O   1 ? 
ATOM   2805 N N   . LEU B 1 60  ? 6.642   -40.658 0.217  1.00 89.35  ? 92  LEU B N   1 ? 
ATOM   2806 C CA  . LEU B 1 60  ? 5.507   -40.228 1.012  1.00 83.66  ? 92  LEU B CA  1 ? 
ATOM   2807 C C   . LEU B 1 60  ? 5.986   -39.948 2.425  1.00 80.40  ? 92  LEU B C   1 ? 
ATOM   2808 O O   . LEU B 1 60  ? 6.636   -40.788 3.047  1.00 67.66  ? 92  LEU B O   1 ? 
ATOM   2809 C CB  . LEU B 1 60  ? 4.388   -41.266 1.076  1.00 83.64  ? 92  LEU B CB  1 ? 
ATOM   2810 C CG  . LEU B 1 60  ? 3.621   -41.540 -0.216 1.00 79.98  ? 92  LEU B CG  1 ? 
ATOM   2811 C CD1 . LEU B 1 60  ? 2.600   -42.618 0.079  1.00 79.67  ? 92  LEU B CD1 1 ? 
ATOM   2812 C CD2 . LEU B 1 60  ? 2.957   -40.306 -0.790 1.00 80.45  ? 92  LEU B CD2 1 ? 
ATOM   2813 N N   . VAL B 1 61  ? 5.579   -38.784 2.929  1.00 79.48  ? 93  VAL B N   1 ? 
ATOM   2814 C CA  . VAL B 1 61  ? 5.740   -38.480 4.332  1.00 75.74  ? 93  VAL B CA  1 ? 
ATOM   2815 C C   . VAL B 1 61  ? 4.550   -39.107 5.033  1.00 70.08  ? 93  VAL B C   1 ? 
ATOM   2816 O O   . VAL B 1 61  ? 3.438   -39.059 4.523  1.00 73.28  ? 93  VAL B O   1 ? 
ATOM   2817 C CB  . VAL B 1 61  ? 5.836   -36.964 4.577  1.00 81.06  ? 93  VAL B CB  1 ? 
ATOM   2818 C CG1 . VAL B 1 61  ? 6.043   -36.629 6.054  1.00 81.24  ? 93  VAL B CG1 1 ? 
ATOM   2819 C CG2 . VAL B 1 61  ? 6.935   -36.340 3.722  1.00 78.32  ? 93  VAL B CG2 1 ? 
ATOM   2820 N N   . MET B 1 62  ? 4.807   -39.701 6.195  1.00 66.52  ? 94  MET B N   1 ? 
ATOM   2821 C CA  . MET B 1 62  ? 3.780   -40.391 6.941  1.00 64.54  ? 94  MET B CA  1 ? 
ATOM   2822 C C   . MET B 1 62  ? 4.022   -40.130 8.420  1.00 71.30  ? 94  MET B C   1 ? 
ATOM   2823 O O   . MET B 1 62  ? 5.045   -39.573 8.799  1.00 69.99  ? 94  MET B O   1 ? 
ATOM   2824 C CB  . MET B 1 62  ? 3.846   -41.917 6.757  1.00 68.23  ? 94  MET B CB  1 ? 
ATOM   2825 C CG  . MET B 1 62  ? 3.858   -42.428 5.327  1.00 69.60  ? 94  MET B CG  1 ? 
ATOM   2826 S SD  . MET B 1 62  ? 3.833   -44.232 5.221  1.00 72.43  ? 94  MET B SD  1 ? 
ATOM   2827 C CE  . MET B 1 62  ? 3.796   -44.232 3.423  1.00 70.82  ? 94  MET B CE  1 ? 
ATOM   2828 N N   . ALA B 1 63  ? 3.074   -40.597 9.231  1.00 73.17  ? 95  ALA B N   1 ? 
ATOM   2829 C CA  . ALA B 1 63  ? 3.226   -40.685 10.664 1.00 74.05  ? 95  ALA B CA  1 ? 
ATOM   2830 C C   . ALA B 1 63  ? 3.147   -42.153 11.036 1.00 79.49  ? 95  ALA B C   1 ? 
ATOM   2831 O O   . ALA B 1 63  ? 2.242   -42.848 10.582 1.00 81.89  ? 95  ALA B O   1 ? 
ATOM   2832 C CB  . ALA B 1 63  ? 2.139   -39.891 11.350 1.00 79.47  ? 95  ALA B CB  1 ? 
ATOM   2833 N N   . ARG B 1 64  ? 4.077   -42.596 11.882 1.00 84.40  ? 96  ARG B N   1 ? 
ATOM   2834 C CA  . ARG B 1 64  ? 4.231   -44.011 12.158 1.00 84.37  ? 96  ARG B CA  1 ? 
ATOM   2835 C C   . ARG B 1 64  ? 4.085   -44.252 13.654 1.00 78.14  ? 96  ARG B C   1 ? 
ATOM   2836 O O   . ARG B 1 64  ? 4.903   -43.800 14.440 1.00 86.11  ? 96  ARG B O   1 ? 
ATOM   2837 C CB  . ARG B 1 64  ? 5.601   -44.459 11.638 1.00 91.43  ? 96  ARG B CB  1 ? 
ATOM   2838 C CG  . ARG B 1 64  ? 5.986   -45.890 11.987 1.00 90.83  ? 96  ARG B CG  1 ? 
ATOM   2839 C CD  . ARG B 1 64  ? 7.377   -46.228 11.483 1.00 94.32  ? 96  ARG B CD  1 ? 
ATOM   2840 N NE  . ARG B 1 64  ? 7.765   -47.615 11.760 1.00 97.94  ? 96  ARG B NE  1 ? 
ATOM   2841 C CZ  . ARG B 1 64  ? 8.957   -48.141 11.493 1.00 98.40  ? 96  ARG B CZ  1 ? 
ATOM   2842 N NH1 . ARG B 1 64  ? 9.910   -47.416 10.919 1.00 92.70  ? 96  ARG B NH1 1 ? 
ATOM   2843 N NH2 . ARG B 1 64  ? 9.186   -49.405 11.800 1.00 97.09  ? 96  ARG B NH2 1 ? 
ATOM   2844 N N   . LYS B 1 65  ? 3.053   -44.994 14.038 1.00 82.87  ? 97  LYS B N   1 ? 
ATOM   2845 C CA  . LYS B 1 65  ? 2.872   -45.326 15.435 1.00 96.71  ? 97  LYS B CA  1 ? 
ATOM   2846 C C   . LYS B 1 65  ? 3.479   -46.703 15.675 1.00 97.08  ? 97  LYS B C   1 ? 
ATOM   2847 O O   . LYS B 1 65  ? 3.054   -47.678 15.062 1.00 104.71 ? 97  LYS B O   1 ? 
ATOM   2848 C CB  . LYS B 1 65  ? 1.393   -45.263 15.834 1.00 102.22 ? 97  LYS B CB  1 ? 
ATOM   2849 C CG  . LYS B 1 65  ? 1.162   -45.479 17.321 1.00 101.85 ? 97  LYS B CG  1 ? 
ATOM   2850 C CD  . LYS B 1 65  ? -0.083  -44.817 17.893 1.00 108.11 ? 97  LYS B CD  1 ? 
ATOM   2851 C CE  . LYS B 1 65  ? -0.201  -45.059 19.365 1.00 110.56 ? 97  LYS B CE  1 ? 
ATOM   2852 N NZ  . LYS B 1 65  ? -1.530  -44.710 19.864 1.00 117.44 ? 97  LYS B NZ  1 ? 
ATOM   2853 N N   . LEU B 1 66  ? 4.482   -46.760 16.557 1.00 100.56 ? 98  LEU B N   1 ? 
ATOM   2854 C CA  . LEU B 1 66  ? 5.034   -48.025 17.004 1.00 98.74  ? 98  LEU B CA  1 ? 
ATOM   2855 C C   . LEU B 1 66  ? 4.348   -48.384 18.316 1.00 87.81  ? 98  LEU B C   1 ? 
ATOM   2856 O O   . LEU B 1 66  ? 4.085   -47.504 19.121 1.00 96.31  ? 98  LEU B O   1 ? 
ATOM   2857 C CB  . LEU B 1 66  ? 6.554   -47.960 17.152 1.00 104.39 ? 98  LEU B CB  1 ? 
ATOM   2858 C CG  . LEU B 1 66  ? 7.342   -47.793 15.848 1.00 108.66 ? 98  LEU B CG  1 ? 
ATOM   2859 C CD1 . LEU B 1 66  ? 7.410   -46.339 15.422 1.00 108.67 ? 98  LEU B CD1 1 ? 
ATOM   2860 C CD2 . LEU B 1 66  ? 8.744   -48.378 15.955 1.00 116.37 ? 98  LEU B CD2 1 ? 
ATOM   2861 N N   . ILE B 1 67  ? 4.019   -49.669 18.480 1.00 91.45  ? 99  ILE B N   1 ? 
ATOM   2862 C CA  . ILE B 1 67  ? 3.455   -50.207 19.706 1.00 101.95 ? 99  ILE B CA  1 ? 
ATOM   2863 C C   . ILE B 1 67  ? 4.253   -51.459 20.060 1.00 113.37 ? 99  ILE B C   1 ? 
ATOM   2864 O O   . ILE B 1 67  ? 4.350   -52.374 19.244 1.00 108.47 ? 99  ILE B O   1 ? 
ATOM   2865 C CB  . ILE B 1 67  ? 1.956   -50.540 19.548 1.00 111.61 ? 99  ILE B CB  1 ? 
ATOM   2866 C CG1 . ILE B 1 67  ? 1.180   -49.429 18.825 1.00 103.27 ? 99  ILE B CG1 1 ? 
ATOM   2867 C CG2 . ILE B 1 67  ? 1.334   -50.883 20.905 1.00 115.65 ? 99  ILE B CG2 1 ? 
ATOM   2868 C CD1 . ILE B 1 67  ? -0.317  -49.668 18.748 1.00 102.83 ? 99  ILE B CD1 1 ? 
ATOM   2869 N N   . HIS B 1 68  ? 4.808   -51.491 21.278 1.00 121.73 ? 100 HIS B N   1 ? 
ATOM   2870 C CA  . HIS B 1 68  ? 5.670   -52.581 21.698 1.00 124.07 ? 100 HIS B CA  1 ? 
ATOM   2871 C C   . HIS B 1 68  ? 4.802   -53.714 22.241 1.00 134.36 ? 100 HIS B C   1 ? 
ATOM   2872 O O   . HIS B 1 68  ? 4.578   -53.801 23.445 1.00 139.74 ? 100 HIS B O   1 ? 
ATOM   2873 C CB  . HIS B 1 68  ? 6.711   -52.062 22.697 1.00 132.27 ? 100 HIS B CB  1 ? 
ATOM   2874 C CG  . HIS B 1 68  ? 7.892   -52.958 22.872 1.00 142.90 ? 100 HIS B CG  1 ? 
ATOM   2875 N ND1 . HIS B 1 68  ? 8.462   -53.650 21.825 1.00 151.80 ? 100 HIS B ND1 1 ? 
ATOM   2876 C CD2 . HIS B 1 68  ? 8.621   -53.260 23.955 1.00 141.16 ? 100 HIS B CD2 1 ? 
ATOM   2877 C CE1 . HIS B 1 68  ? 9.492   -54.353 22.275 1.00 152.30 ? 100 HIS B CE1 1 ? 
ATOM   2878 N NE2 . HIS B 1 68  ? 9.606   -54.130 23.566 1.00 147.91 ? 100 HIS B NE2 1 ? 
ATOM   2879 N N   . LEU B 1 69  ? 4.295   -54.559 21.333 1.00 146.57 ? 101 LEU B N   1 ? 
ATOM   2880 C CA  . LEU B 1 69  ? 3.555   -55.760 21.694 1.00 163.84 ? 101 LEU B CA  1 ? 
ATOM   2881 C C   . LEU B 1 69  ? 4.209   -56.955 21.000 1.00 183.51 ? 101 LEU B C   1 ? 
ATOM   2882 O O   . LEU B 1 69  ? 4.688   -56.828 19.875 1.00 196.04 ? 101 LEU B O   1 ? 
ATOM   2883 C CB  . LEU B 1 69  ? 2.083   -55.593 21.304 1.00 160.71 ? 101 LEU B CB  1 ? 
ATOM   2884 C CG  . LEU B 1 69  ? 1.068   -56.585 21.892 1.00 166.57 ? 101 LEU B CG  1 ? 
ATOM   2885 C CD1 . LEU B 1 69  ? 0.982   -57.869 21.082 1.00 162.10 ? 101 LEU B CD1 1 ? 
ATOM   2886 C CD2 . LEU B 1 69  ? 1.330   -56.919 23.359 1.00 168.49 ? 101 LEU B CD2 1 ? 
ATOM   2887 N N   . GLU B 1 70  ? 4.230   -58.110 21.684 1.00 184.83 ? 102 GLU B N   1 ? 
ATOM   2888 C CA  . GLU B 1 70  ? 4.924   -59.296 21.203 1.00 181.87 ? 102 GLU B CA  1 ? 
ATOM   2889 C C   . GLU B 1 70  ? 3.906   -60.389 20.878 1.00 173.45 ? 102 GLU B C   1 ? 
ATOM   2890 O O   . GLU B 1 70  ? 3.121   -60.775 21.741 1.00 175.13 ? 102 GLU B O   1 ? 
ATOM   2891 C CB  . GLU B 1 70  ? 5.912   -59.795 22.259 1.00 188.52 ? 102 GLU B CB  1 ? 
ATOM   2892 C CG  . GLU B 1 70  ? 6.594   -58.683 23.053 1.00 194.03 ? 102 GLU B CG  1 ? 
ATOM   2893 C CD  . GLU B 1 70  ? 7.315   -57.640 22.216 1.00 203.33 ? 102 GLU B CD  1 ? 
ATOM   2894 O OE1 . GLU B 1 70  ? 8.208   -58.022 21.431 1.00 208.82 ? 102 GLU B OE1 1 ? 
ATOM   2895 O OE2 . GLU B 1 70  ? 6.986   -56.444 22.354 1.00 213.90 ? 102 GLU B OE2 1 ? 
ATOM   2896 N N   . ILE B 1 71  ? 3.939   -60.887 19.634 1.00 164.71 ? 103 ILE B N   1 ? 
ATOM   2897 C CA  . ILE B 1 71  ? 2.988   -61.884 19.159 1.00 157.87 ? 103 ILE B CA  1 ? 
ATOM   2898 C C   . ILE B 1 71  ? 3.749   -63.043 18.517 1.00 151.29 ? 103 ILE B C   1 ? 
ATOM   2899 O O   . ILE B 1 71  ? 4.813   -62.847 17.932 1.00 143.78 ? 103 ILE B O   1 ? 
ATOM   2900 C CB  . ILE B 1 71  ? 1.955   -61.267 18.191 1.00 159.23 ? 103 ILE B CB  1 ? 
ATOM   2901 C CG1 . ILE B 1 71  ? 2.602   -60.342 17.154 1.00 159.34 ? 103 ILE B CG1 1 ? 
ATOM   2902 C CG2 . ILE B 1 71  ? 0.848   -60.550 18.963 1.00 156.15 ? 103 ILE B CG2 1 ? 
ATOM   2903 C CD1 . ILE B 1 71  ? 1.643   -59.832 16.092 1.00 154.03 ? 103 ILE B CD1 1 ? 
ATOM   2904 N N   . LYS B 1 72  ? 3.171   -64.248 18.622 1.00 151.48 ? 104 LYS B N   1 ? 
ATOM   2905 C CA  . LYS B 1 72  ? 3.794   -65.473 18.139 1.00 152.48 ? 104 LYS B CA  1 ? 
ATOM   2906 C C   . LYS B 1 72  ? 4.203   -65.300 16.677 1.00 146.26 ? 104 LYS B C   1 ? 
ATOM   2907 O O   . LYS B 1 72  ? 3.529   -64.612 15.918 1.00 122.47 ? 104 LYS B O   1 ? 
ATOM   2908 C CB  . LYS B 1 72  ? 2.872   -66.696 18.265 1.00 151.82 ? 104 LYS B CB  1 ? 
ATOM   2909 C CG  . LYS B 1 72  ? 2.115   -66.869 19.583 1.00 150.68 ? 104 LYS B CG  1 ? 
ATOM   2910 C CD  . LYS B 1 72  ? 2.964   -66.889 20.850 1.00 142.72 ? 104 LYS B CD  1 ? 
ATOM   2911 C CE  . LYS B 1 72  ? 2.191   -66.481 22.066 1.00 140.04 ? 104 LYS B CE  1 ? 
ATOM   2912 N NZ  . LYS B 1 72  ? 1.771   -65.077 22.006 1.00 140.77 ? 104 LYS B NZ  1 ? 
ATOM   2913 N N   . PRO B 1 73  ? 5.306   -65.940 16.227 1.00 159.71 ? 105 PRO B N   1 ? 
ATOM   2914 C CA  . PRO B 1 73  ? 5.779   -65.782 14.848 1.00 160.01 ? 105 PRO B CA  1 ? 
ATOM   2915 C C   . PRO B 1 73  ? 4.993   -66.552 13.784 1.00 151.44 ? 105 PRO B C   1 ? 
ATOM   2916 O O   . PRO B 1 73  ? 5.567   -67.027 12.806 1.00 142.42 ? 105 PRO B O   1 ? 
ATOM   2917 C CB  . PRO B 1 73  ? 7.229   -66.285 14.991 1.00 167.54 ? 105 PRO B CB  1 ? 
ATOM   2918 C CG  . PRO B 1 73  ? 7.115   -67.404 15.996 1.00 172.96 ? 105 PRO B CG  1 ? 
ATOM   2919 C CD  . PRO B 1 73  ? 6.155   -66.840 17.027 1.00 169.55 ? 105 PRO B CD  1 ? 
ATOM   2920 N N   . ALA B 1 74  ? 3.675   -66.673 13.984 1.00 145.56 ? 106 ALA B N   1 ? 
ATOM   2921 C CA  . ALA B 1 74  ? 2.788   -67.209 12.962 1.00 154.34 ? 106 ALA B CA  1 ? 
ATOM   2922 C C   . ALA B 1 74  ? 1.390   -66.598 13.071 1.00 159.48 ? 106 ALA B C   1 ? 
ATOM   2923 O O   . ALA B 1 74  ? 0.666   -66.572 12.077 1.00 160.40 ? 106 ALA B O   1 ? 
ATOM   2924 C CB  . ALA B 1 74  ? 2.741   -68.719 13.043 1.00 156.43 ? 106 ALA B CB  1 ? 
ATOM   2925 N N   . ILE B 1 75  ? 1.008   -66.125 14.270 1.00 163.66 ? 107 ILE B N   1 ? 
ATOM   2926 C CA  . ILE B 1 75  ? -0.255  -65.422 14.451 1.00 164.18 ? 107 ILE B CA  1 ? 
ATOM   2927 C C   . ILE B 1 75  ? -0.166  -64.052 13.781 1.00 170.81 ? 107 ILE B C   1 ? 
ATOM   2928 O O   . ILE B 1 75  ? -1.170  -63.554 13.279 1.00 178.87 ? 107 ILE B O   1 ? 
ATOM   2929 C CB  . ILE B 1 75  ? -0.669  -65.305 15.935 1.00 158.24 ? 107 ILE B CB  1 ? 
ATOM   2930 C CG1 . ILE B 1 75  ? 0.257   -64.388 16.750 1.00 159.29 ? 107 ILE B CG1 1 ? 
ATOM   2931 C CG2 . ILE B 1 75  ? -0.801  -66.690 16.574 1.00 157.94 ? 107 ILE B CG2 1 ? 
ATOM   2932 C CD1 . ILE B 1 75  ? -0.260  -64.073 18.145 1.00 158.76 ? 107 ILE B CD1 1 ? 
ATOM   2933 N N   . ARG B 1 76  ? 1.041   -63.465 13.771 1.00 168.19 ? 108 ARG B N   1 ? 
ATOM   2934 C CA  . ARG B 1 76  ? 1.275   -62.126 13.241 1.00 156.15 ? 108 ARG B CA  1 ? 
ATOM   2935 C C   . ARG B 1 76  ? 0.451   -61.935 11.969 1.00 146.40 ? 108 ARG B C   1 ? 
ATOM   2936 O O   . ARG B 1 76  ? -0.347  -61.002 11.881 1.00 137.17 ? 108 ARG B O   1 ? 
ATOM   2937 C CB  . ARG B 1 76  ? 2.751   -61.797 12.952 1.00 149.06 ? 108 ARG B CB  1 ? 
ATOM   2938 C CG  . ARG B 1 76  ? 3.791   -62.562 13.761 1.00 147.50 ? 108 ARG B CG  1 ? 
ATOM   2939 C CD  . ARG B 1 76  ? 4.783   -61.701 14.530 1.00 153.98 ? 108 ARG B CD  1 ? 
ATOM   2940 N NE  . ARG B 1 76  ? 6.182   -61.782 14.094 1.00 156.25 ? 108 ARG B NE  1 ? 
ATOM   2941 C CZ  . ARG B 1 76  ? 7.232   -62.006 14.895 1.00 149.53 ? 108 ARG B CZ  1 ? 
ATOM   2942 N NH1 . ARG B 1 76  ? 7.077   -62.171 16.201 1.00 143.80 ? 108 ARG B NH1 1 ? 
ATOM   2943 N NH2 . ARG B 1 76  ? 8.453   -62.043 14.388 1.00 143.19 ? 108 ARG B NH2 1 ? 
ATOM   2944 N N   . ASN B 1 77  ? 0.618   -62.862 11.015 1.00 138.76 ? 109 ASN B N   1 ? 
ATOM   2945 C CA  . ASN B 1 77  ? -0.038  -62.792 9.717  1.00 142.47 ? 109 ASN B CA  1 ? 
ATOM   2946 C C   . ASN B 1 77  ? -1.540  -62.568 9.877  1.00 146.60 ? 109 ASN B C   1 ? 
ATOM   2947 O O   . ASN B 1 77  ? -2.182  -62.071 8.955  1.00 153.09 ? 109 ASN B O   1 ? 
ATOM   2948 C CB  . ASN B 1 77  ? 0.212   -64.047 8.885  1.00 139.96 ? 109 ASN B CB  1 ? 
ATOM   2949 C CG  . ASN B 1 77  ? 1.641   -64.147 8.404  1.00 135.93 ? 109 ASN B CG  1 ? 
ATOM   2950 O OD1 . ASN B 1 77  ? 1.987   -63.571 7.367  1.00 121.92 ? 109 ASN B OD1 1 ? 
ATOM   2951 N ND2 . ASN B 1 77  ? 2.476   -64.884 9.126  1.00 140.63 ? 109 ASN B ND2 1 ? 
ATOM   2952 N N   . GLN B 1 78  ? -2.088  -62.945 11.040 1.00 145.01 ? 110 GLN B N   1 ? 
ATOM   2953 C CA  . GLN B 1 78  ? -3.510  -62.820 11.318 1.00 146.21 ? 110 GLN B CA  1 ? 
ATOM   2954 C C   . GLN B 1 78  ? -3.807  -61.569 12.148 1.00 139.28 ? 110 GLN B C   1 ? 
ATOM   2955 O O   . GLN B 1 78  ? -4.919  -61.048 12.080 1.00 135.26 ? 110 GLN B O   1 ? 
ATOM   2956 C CB  . GLN B 1 78  ? -4.009  -64.072 12.038 1.00 148.22 ? 110 GLN B CB  1 ? 
ATOM   2957 C CG  . GLN B 1 78  ? -3.599  -65.381 11.372 1.00 148.30 ? 110 GLN B CG  1 ? 
ATOM   2958 C CD  . GLN B 1 78  ? -3.980  -66.590 12.194 1.00 148.68 ? 110 GLN B CD  1 ? 
ATOM   2959 O OE1 . GLN B 1 78  ? -3.123  -67.277 12.761 1.00 143.76 ? 110 GLN B OE1 1 ? 
ATOM   2960 N NE2 . GLN B 1 78  ? -5.276  -66.845 12.289 1.00 152.40 ? 110 GLN B NE2 1 ? 
ATOM   2961 N N   . ILE B 1 79  ? -2.833  -61.101 12.942 1.00 133.45 ? 111 ILE B N   1 ? 
ATOM   2962 C CA  . ILE B 1 79  ? -2.995  -59.880 13.721 1.00 138.82 ? 111 ILE B CA  1 ? 
ATOM   2963 C C   . ILE B 1 79  ? -3.006  -58.679 12.777 1.00 142.16 ? 111 ILE B C   1 ? 
ATOM   2964 O O   . ILE B 1 79  ? -3.903  -57.843 12.856 1.00 152.47 ? 111 ILE B O   1 ? 
ATOM   2965 C CB  . ILE B 1 79  ? -1.906  -59.729 14.803 1.00 148.30 ? 111 ILE B CB  1 ? 
ATOM   2966 C CG1 . ILE B 1 79  ? -2.200  -60.578 16.048 1.00 149.21 ? 111 ILE B CG1 1 ? 
ATOM   2967 C CG2 . ILE B 1 79  ? -1.722  -58.258 15.186 1.00 150.21 ? 111 ILE B CG2 1 ? 
ATOM   2968 C CD1 . ILE B 1 79  ? -2.094  -62.075 15.833 1.00 153.19 ? 111 ILE B CD1 1 ? 
ATOM   2969 N N   . ILE B 1 80  ? -1.994  -58.596 11.904 1.00 133.38 ? 112 ILE B N   1 ? 
ATOM   2970 C CA  . ILE B 1 80  ? -1.859  -57.486 10.970 1.00 121.51 ? 112 ILE B CA  1 ? 
ATOM   2971 C C   . ILE B 1 80  ? -3.103  -57.423 10.083 1.00 116.84 ? 112 ILE B C   1 ? 
ATOM   2972 O O   . ILE B 1 80  ? -3.597  -56.334 9.805  1.00 125.25 ? 112 ILE B O   1 ? 
ATOM   2973 C CB  . ILE B 1 80  ? -0.550  -57.600 10.155 1.00 115.36 ? 112 ILE B CB  1 ? 
ATOM   2974 C CG1 . ILE B 1 80  ? 0.697   -57.594 11.050 1.00 112.82 ? 112 ILE B CG1 1 ? 
ATOM   2975 C CG2 . ILE B 1 80  ? -0.442  -56.518 9.081  1.00 102.80 ? 112 ILE B CG2 1 ? 
ATOM   2976 C CD1 . ILE B 1 80  ? 0.840   -56.364 11.927 1.00 108.50 ? 112 ILE B CD1 1 ? 
ATOM   2977 N N   . ARG B 1 81  ? -3.624  -58.586 9.672  1.00 115.91 ? 113 ARG B N   1 ? 
ATOM   2978 C CA  . ARG B 1 81  ? -4.750  -58.653 8.751  1.00 130.91 ? 113 ARG B CA  1 ? 
ATOM   2979 C C   . ARG B 1 81  ? -5.891  -57.732 9.177  1.00 140.98 ? 113 ARG B C   1 ? 
ATOM   2980 O O   . ARG B 1 81  ? -6.513  -57.108 8.321  1.00 155.83 ? 113 ARG B O   1 ? 
ATOM   2981 C CB  . ARG B 1 81  ? -5.346  -60.058 8.602  1.00 136.17 ? 113 ARG B CB  1 ? 
ATOM   2982 C CG  . ARG B 1 81  ? -4.881  -60.812 7.367  1.00 143.74 ? 113 ARG B CG  1 ? 
ATOM   2983 C CD  . ARG B 1 81  ? -5.695  -62.080 7.163  1.00 152.56 ? 113 ARG B CD  1 ? 
ATOM   2984 N NE  . ARG B 1 81  ? -5.173  -62.882 6.050  1.00 157.66 ? 113 ARG B NE  1 ? 
ATOM   2985 C CZ  . ARG B 1 81  ? -4.050  -63.596 6.062  1.00 152.44 ? 113 ARG B CZ  1 ? 
ATOM   2986 N NH1 . ARG B 1 81  ? -3.624  -64.154 4.943  1.00 150.35 ? 113 ARG B NH1 1 ? 
ATOM   2987 N NH2 . ARG B 1 81  ? -3.344  -63.736 7.173  1.00 150.78 ? 113 ARG B NH2 1 ? 
ATOM   2988 N N   . GLU B 1 82  ? -6.182  -57.669 10.485 1.00 139.93 ? 114 GLU B N   1 ? 
ATOM   2989 C CA  . GLU B 1 82  ? -7.336  -56.920 10.966 1.00 147.15 ? 114 GLU B CA  1 ? 
ATOM   2990 C C   . GLU B 1 82  ? -7.158  -55.420 10.723 1.00 156.18 ? 114 GLU B C   1 ? 
ATOM   2991 O O   . GLU B 1 82  ? -8.146  -54.706 10.561 1.00 165.22 ? 114 GLU B O   1 ? 
ATOM   2992 C CB  . GLU B 1 82  ? -7.654  -57.187 12.440 1.00 141.12 ? 114 GLU B CB  1 ? 
ATOM   2993 C CG  . GLU B 1 82  ? -8.434  -58.480 12.671 1.00 140.75 ? 114 GLU B CG  1 ? 
ATOM   2994 C CD  . GLU B 1 82  ? -9.399  -58.446 13.846 1.00 137.02 ? 114 GLU B CD  1 ? 
ATOM   2995 O OE1 . GLU B 1 82  ? -8.939  -58.260 14.994 1.00 128.23 ? 114 GLU B OE1 1 ? 
ATOM   2996 O OE2 . GLU B 1 82  ? -10.619 -58.605 13.609 1.00 127.44 ? 114 GLU B OE2 1 ? 
ATOM   2997 N N   . LEU B 1 83  ? -5.908  -54.943 10.696 1.00 146.48 ? 115 LEU B N   1 ? 
ATOM   2998 C CA  . LEU B 1 83  ? -5.642  -53.524 10.524 1.00 137.46 ? 115 LEU B CA  1 ? 
ATOM   2999 C C   . LEU B 1 83  ? -5.821  -53.111 9.061  1.00 131.28 ? 115 LEU B C   1 ? 
ATOM   3000 O O   . LEU B 1 83  ? -6.144  -51.955 8.799  1.00 135.63 ? 115 LEU B O   1 ? 
ATOM   3001 C CB  . LEU B 1 83  ? -4.257  -53.168 11.061 1.00 142.50 ? 115 LEU B CB  1 ? 
ATOM   3002 C CG  . LEU B 1 83  ? -4.117  -53.168 12.588 1.00 145.45 ? 115 LEU B CG  1 ? 
ATOM   3003 C CD1 . LEU B 1 83  ? -3.991  -54.571 13.176 1.00 137.77 ? 115 LEU B CD1 1 ? 
ATOM   3004 C CD2 . LEU B 1 83  ? -2.937  -52.303 13.003 1.00 146.49 ? 115 LEU B CD2 1 ? 
ATOM   3005 N N   . GLN B 1 84  ? -5.641  -54.046 8.114  1.00 124.91 ? 116 GLN B N   1 ? 
ATOM   3006 C CA  . GLN B 1 84  ? -5.882  -53.776 6.698  1.00 133.94 ? 116 GLN B CA  1 ? 
ATOM   3007 C C   . GLN B 1 84  ? -7.351  -53.429 6.431  1.00 131.87 ? 116 GLN B C   1 ? 
ATOM   3008 O O   . GLN B 1 84  ? -7.704  -53.018 5.324  1.00 113.10 ? 116 GLN B O   1 ? 
ATOM   3009 C CB  . GLN B 1 84  ? -5.473  -54.940 5.790  1.00 138.25 ? 116 GLN B CB  1 ? 
ATOM   3010 C CG  . GLN B 1 84  ? -4.112  -54.780 5.118  1.00 137.12 ? 116 GLN B CG  1 ? 
ATOM   3011 C CD  . GLN B 1 84  ? -2.949  -54.681 6.080  1.00 138.69 ? 116 GLN B CD  1 ? 
ATOM   3012 O OE1 . GLN B 1 84  ? -2.030  -53.870 5.908  1.00 125.44 ? 116 GLN B OE1 1 ? 
ATOM   3013 N NE2 . GLN B 1 84  ? -2.958  -55.539 7.089  1.00 139.46 ? 116 GLN B NE2 1 ? 
ATOM   3014 N N   . VAL B 1 85  ? -8.206  -53.581 7.448  1.00 130.52 ? 117 VAL B N   1 ? 
ATOM   3015 C CA  . VAL B 1 85  ? -9.601  -53.185 7.347  1.00 133.51 ? 117 VAL B CA  1 ? 
ATOM   3016 C C   . VAL B 1 85  ? -9.708  -51.664 7.172  1.00 128.94 ? 117 VAL B C   1 ? 
ATOM   3017 O O   . VAL B 1 85  ? -10.629 -51.186 6.515  1.00 128.02 ? 117 VAL B O   1 ? 
ATOM   3018 C CB  . VAL B 1 85  ? -10.386 -53.689 8.578  1.00 136.03 ? 117 VAL B CB  1 ? 
ATOM   3019 C CG1 . VAL B 1 85  ? -11.852 -53.275 8.536  1.00 138.62 ? 117 VAL B CG1 1 ? 
ATOM   3020 C CG2 . VAL B 1 85  ? -10.291 -55.204 8.738  1.00 132.28 ? 117 VAL B CG2 1 ? 
ATOM   3021 N N   . LEU B 1 86  ? -8.746  -50.906 7.720  1.00 121.36 ? 118 LEU B N   1 ? 
ATOM   3022 C CA  . LEU B 1 86  ? -8.843  -49.455 7.814  1.00 106.88 ? 118 LEU B CA  1 ? 
ATOM   3023 C C   . LEU B 1 86  ? -8.622  -48.781 6.459  1.00 106.51 ? 118 LEU B C   1 ? 
ATOM   3024 O O   . LEU B 1 86  ? -8.654  -47.558 6.378  1.00 99.56  ? 118 LEU B O   1 ? 
ATOM   3025 C CB  . LEU B 1 86  ? -7.835  -48.959 8.851  1.00 112.51 ? 118 LEU B CB  1 ? 
ATOM   3026 C CG  . LEU B 1 86  ? -7.989  -49.508 10.276 1.00 110.74 ? 118 LEU B CG  1 ? 
ATOM   3027 C CD1 . LEU B 1 86  ? -6.780  -49.133 11.122 1.00 108.88 ? 118 LEU B CD1 1 ? 
ATOM   3028 C CD2 . LEU B 1 86  ? -9.275  -49.026 10.940 1.00 109.52 ? 118 LEU B CD2 1 ? 
ATOM   3029 N N   . HIS B 1 87  ? -8.385  -49.577 5.405  1.00 123.46 ? 119 HIS B N   1 ? 
ATOM   3030 C CA  . HIS B 1 87  ? -8.430  -49.100 4.029  1.00 127.80 ? 119 HIS B CA  1 ? 
ATOM   3031 C C   . HIS B 1 87  ? -9.869  -48.768 3.633  1.00 130.59 ? 119 HIS B C   1 ? 
ATOM   3032 O O   . HIS B 1 87  ? -10.090 -47.924 2.768  1.00 114.63 ? 119 HIS B O   1 ? 
ATOM   3033 C CB  . HIS B 1 87  ? -7.885  -50.160 3.060  1.00 128.61 ? 119 HIS B CB  1 ? 
ATOM   3034 C CG  . HIS B 1 87  ? -6.395  -50.291 3.019  1.00 130.24 ? 119 HIS B CG  1 ? 
ATOM   3035 N ND1 . HIS B 1 87  ? -5.530  -49.224 3.137  1.00 123.43 ? 119 HIS B ND1 1 ? 
ATOM   3036 C CD2 . HIS B 1 87  ? -5.622  -51.373 2.833  1.00 130.25 ? 119 HIS B CD2 1 ? 
ATOM   3037 C CE1 . HIS B 1 87  ? -4.282  -49.660 3.036  1.00 122.38 ? 119 HIS B CE1 1 ? 
ATOM   3038 N NE2 . HIS B 1 87  ? -4.314  -50.961 2.852  1.00 121.89 ? 119 HIS B NE2 1 ? 
ATOM   3039 N N   . GLU B 1 88  ? -10.830 -49.453 4.271  1.00 148.22 ? 120 GLU B N   1 ? 
ATOM   3040 C CA  . GLU B 1 88  ? -12.249 -49.353 3.952  1.00 161.08 ? 120 GLU B CA  1 ? 
ATOM   3041 C C   . GLU B 1 88  ? -12.844 -48.056 4.516  1.00 163.48 ? 120 GLU B C   1 ? 
ATOM   3042 O O   . GLU B 1 88  ? -13.842 -47.570 3.985  1.00 174.67 ? 120 GLU B O   1 ? 
ATOM   3043 C CB  . GLU B 1 88  ? -12.897 -50.674 4.385  1.00 171.15 ? 120 GLU B CB  1 ? 
ATOM   3044 C CG  . GLU B 1 88  ? -14.422 -50.683 4.475  1.00 187.57 ? 120 GLU B CG  1 ? 
ATOM   3045 C CD  . GLU B 1 88  ? -14.960 -50.405 5.870  1.00 201.84 ? 120 GLU B CD  1 ? 
ATOM   3046 O OE1 . GLU B 1 88  ? -15.348 -51.376 6.557  1.00 204.51 ? 120 GLU B OE1 1 ? 
ATOM   3047 O OE2 . GLU B 1 88  ? -15.004 -49.224 6.270  1.00 210.22 ? 120 GLU B OE2 1 ? 
ATOM   3048 N N   . CYS B 1 89  ? -12.243 -47.500 5.582  1.00 150.87 ? 121 CYS B N   1 ? 
ATOM   3049 C CA  . CYS B 1 89  ? -12.508 -46.124 5.983  1.00 120.02 ? 121 CYS B CA  1 ? 
ATOM   3050 C C   . CYS B 1 89  ? -12.045 -45.181 4.879  1.00 107.10 ? 121 CYS B C   1 ? 
ATOM   3051 O O   . CYS B 1 89  ? -10.896 -45.237 4.446  1.00 98.73  ? 121 CYS B O   1 ? 
ATOM   3052 C CB  . CYS B 1 89  ? -11.752 -45.716 7.242  1.00 124.61 ? 121 CYS B CB  1 ? 
ATOM   3053 S SG  . CYS B 1 89  ? -12.681 -45.963 8.776  1.00 138.03 ? 121 CYS B SG  1 ? 
ATOM   3054 N N   . ASN B 1 90  ? -12.950 -44.321 4.418  1.00 106.44 ? 122 ASN B N   1 ? 
ATOM   3055 C CA  . ASN B 1 90  ? -12.582 -43.322 3.433  1.00 108.80 ? 122 ASN B CA  1 ? 
ATOM   3056 C C   . ASN B 1 90  ? -13.517 -42.132 3.584  1.00 107.26 ? 122 ASN B C   1 ? 
ATOM   3057 O O   . ASN B 1 90  ? -14.569 -42.064 2.953  1.00 109.78 ? 122 ASN B O   1 ? 
ATOM   3058 C CB  . ASN B 1 90  ? -12.555 -43.878 2.017  1.00 108.40 ? 122 ASN B CB  1 ? 
ATOM   3059 C CG  . ASN B 1 90  ? -11.532 -43.145 1.186  1.00 118.37 ? 122 ASN B CG  1 ? 
ATOM   3060 O OD1 . ASN B 1 90  ? -11.897 -42.286 0.377  1.00 124.75 ? 122 ASN B OD1 1 ? 
ATOM   3061 N ND2 . ASN B 1 90  ? -10.255 -43.431 1.406  1.00 117.14 ? 122 ASN B ND2 1 ? 
ATOM   3062 N N   . SER B 1 91  ? -13.104 -41.216 4.459  1.00 109.17 ? 123 SER B N   1 ? 
ATOM   3063 C CA  . SER B 1 91  ? -13.882 -40.047 4.812  1.00 96.01  ? 123 SER B CA  1 ? 
ATOM   3064 C C   . SER B 1 91  ? -12.966 -38.833 4.872  1.00 95.59  ? 123 SER B C   1 ? 
ATOM   3065 O O   . SER B 1 91  ? -11.782 -38.960 5.199  1.00 97.37  ? 123 SER B O   1 ? 
ATOM   3066 C CB  . SER B 1 91  ? -14.572 -40.245 6.129  1.00 90.19  ? 123 SER B CB  1 ? 
ATOM   3067 O OG  . SER B 1 91  ? -15.131 -39.023 6.584  1.00 91.34  ? 123 SER B OG  1 ? 
ATOM   3068 N N   . PRO B 1 92  ? -13.503 -37.616 4.632  1.00 86.37  ? 124 PRO B N   1 ? 
ATOM   3069 C CA  . PRO B 1 92  ? -12.709 -36.394 4.742  1.00 89.58  ? 124 PRO B CA  1 ? 
ATOM   3070 C C   . PRO B 1 92  ? -12.515 -35.990 6.203  1.00 80.25  ? 124 PRO B C   1 ? 
ATOM   3071 O O   . PRO B 1 92  ? -11.785 -35.037 6.485  1.00 78.29  ? 124 PRO B O   1 ? 
ATOM   3072 C CB  . PRO B 1 92  ? -13.528 -35.354 3.947  1.00 90.08  ? 124 PRO B CB  1 ? 
ATOM   3073 C CG  . PRO B 1 92  ? -14.710 -36.121 3.386  1.00 88.22  ? 124 PRO B CG  1 ? 
ATOM   3074 C CD  . PRO B 1 92  ? -14.900 -37.331 4.281  1.00 88.38  ? 124 PRO B CD  1 ? 
ATOM   3075 N N   . TYR B 1 93  ? -13.176 -36.740 7.101  1.00 65.92  ? 125 TYR B N   1 ? 
ATOM   3076 C CA  . TYR B 1 93  ? -13.236 -36.458 8.525  1.00 70.51  ? 125 TYR B CA  1 ? 
ATOM   3077 C C   . TYR B 1 93  ? -12.632 -37.615 9.309  1.00 72.14  ? 125 TYR B C   1 ? 
ATOM   3078 O O   . TYR B 1 93  ? -12.871 -37.727 10.508 1.00 73.97  ? 125 TYR B O   1 ? 
ATOM   3079 C CB  . TYR B 1 93  ? -14.688 -36.259 8.979  1.00 79.10  ? 125 TYR B CB  1 ? 
ATOM   3080 C CG  . TYR B 1 93  ? -15.441 -35.232 8.142  1.00 88.36  ? 125 TYR B CG  1 ? 
ATOM   3081 C CD1 . TYR B 1 93  ? -15.119 -33.880 8.217  1.00 80.26  ? 125 TYR B CD1 1 ? 
ATOM   3082 C CD2 . TYR B 1 93  ? -16.453 -35.613 7.263  1.00 87.53  ? 125 TYR B CD2 1 ? 
ATOM   3083 C CE1 . TYR B 1 93  ? -15.780 -32.941 7.442  1.00 89.83  ? 125 TYR B CE1 1 ? 
ATOM   3084 C CE2 . TYR B 1 93  ? -17.130 -34.681 6.496  1.00 84.30  ? 125 TYR B CE2 1 ? 
ATOM   3085 C CZ  . TYR B 1 93  ? -16.792 -33.342 6.587  1.00 90.89  ? 125 TYR B CZ  1 ? 
ATOM   3086 O OH  . TYR B 1 93  ? -17.442 -32.417 5.828  1.00 102.30 ? 125 TYR B OH  1 ? 
ATOM   3087 N N   . ILE B 1 94  ? -11.900 -38.494 8.613  1.00 75.59  ? 126 ILE B N   1 ? 
ATOM   3088 C CA  . ILE B 1 94  ? -11.241 -39.629 9.240  1.00 73.39  ? 126 ILE B CA  1 ? 
ATOM   3089 C C   . ILE B 1 94  ? -9.839  -39.719 8.643  1.00 64.90  ? 126 ILE B C   1 ? 
ATOM   3090 O O   . ILE B 1 94  ? -9.693  -39.719 7.423  1.00 73.49  ? 126 ILE B O   1 ? 
ATOM   3091 C CB  . ILE B 1 94  ? -12.047 -40.930 9.047  1.00 73.89  ? 126 ILE B CB  1 ? 
ATOM   3092 C CG1 . ILE B 1 94  ? -13.464 -40.829 9.607  1.00 71.37  ? 126 ILE B CG1 1 ? 
ATOM   3093 C CG2 . ILE B 1 94  ? -11.314 -42.125 9.663  1.00 78.16  ? 126 ILE B CG2 1 ? 
ATOM   3094 C CD1 . ILE B 1 94  ? -13.538 -40.891 11.126 1.00 72.63  ? 126 ILE B CD1 1 ? 
ATOM   3095 N N   . VAL B 1 95  ? -8.823  -39.750 9.513  1.00 69.31  ? 127 VAL B N   1 ? 
ATOM   3096 C CA  . VAL B 1 95  ? -7.420  -39.691 9.105  1.00 71.58  ? 127 VAL B CA  1 ? 
ATOM   3097 C C   . VAL B 1 95  ? -7.086  -40.885 8.214  1.00 65.18  ? 127 VAL B C   1 ? 
ATOM   3098 O O   . VAL B 1 95  ? -7.319  -42.030 8.597  1.00 58.95  ? 127 VAL B O   1 ? 
ATOM   3099 C CB  . VAL B 1 95  ? -6.497  -39.684 10.337 1.00 70.88  ? 127 VAL B CB  1 ? 
ATOM   3100 C CG1 . VAL B 1 95  ? -5.034  -39.871 9.953  1.00 69.66  ? 127 VAL B CG1 1 ? 
ATOM   3101 C CG2 . VAL B 1 95  ? -6.690  -38.423 11.175 1.00 77.60  ? 127 VAL B CG2 1 ? 
ATOM   3102 N N   . GLY B 1 96  ? -6.527  -40.601 7.034  1.00 60.94  ? 128 GLY B N   1 ? 
ATOM   3103 C CA  . GLY B 1 96  ? -6.098  -41.629 6.098  1.00 65.98  ? 128 GLY B CA  1 ? 
ATOM   3104 C C   . GLY B 1 96  ? -5.153  -42.661 6.724  1.00 69.48  ? 128 GLY B C   1 ? 
ATOM   3105 O O   . GLY B 1 96  ? -4.446  -42.379 7.691  1.00 63.64  ? 128 GLY B O   1 ? 
ATOM   3106 N N   . PHE B 1 97  ? -5.174  -43.875 6.151  1.00 74.39  ? 129 PHE B N   1 ? 
ATOM   3107 C CA  . PHE B 1 97  ? -4.370  -44.999 6.603  1.00 69.83  ? 129 PHE B CA  1 ? 
ATOM   3108 C C   . PHE B 1 97  ? -3.560  -45.539 5.428  1.00 72.06  ? 129 PHE B C   1 ? 
ATOM   3109 O O   . PHE B 1 97  ? -4.110  -45.782 4.366  1.00 74.78  ? 129 PHE B O   1 ? 
ATOM   3110 C CB  . PHE B 1 97  ? -5.286  -46.072 7.181  1.00 69.73  ? 129 PHE B CB  1 ? 
ATOM   3111 C CG  . PHE B 1 97  ? -4.624  -47.408 7.485  1.00 81.36  ? 129 PHE B CG  1 ? 
ATOM   3112 C CD1 . PHE B 1 97  ? -3.837  -47.573 8.618  1.00 87.21  ? 129 PHE B CD1 1 ? 
ATOM   3113 C CD2 . PHE B 1 97  ? -4.837  -48.513 6.668  1.00 87.44  ? 129 PHE B CD2 1 ? 
ATOM   3114 C CE1 . PHE B 1 97  ? -3.273  -48.803 8.918  1.00 85.25  ? 129 PHE B CE1 1 ? 
ATOM   3115 C CE2 . PHE B 1 97  ? -4.264  -49.740 6.971  1.00 90.18  ? 129 PHE B CE2 1 ? 
ATOM   3116 C CZ  . PHE B 1 97  ? -3.489  -49.884 8.100  1.00 84.60  ? 129 PHE B CZ  1 ? 
ATOM   3117 N N   . TYR B 1 98  ? -2.252  -45.717 5.636  1.00 72.85  ? 130 TYR B N   1 ? 
ATOM   3118 C CA  . TYR B 1 98  ? -1.345  -46.141 4.587  1.00 66.99  ? 130 TYR B CA  1 ? 
ATOM   3119 C C   . TYR B 1 98  ? -1.153  -47.649 4.657  1.00 67.77  ? 130 TYR B C   1 ? 
ATOM   3120 O O   . TYR B 1 98  ? -1.161  -48.300 3.623  1.00 68.71  ? 130 TYR B O   1 ? 
ATOM   3121 C CB  . TYR B 1 98  ? -0.005  -45.410 4.684  1.00 66.27  ? 130 TYR B CB  1 ? 
ATOM   3122 C CG  . TYR B 1 98  ? -0.050  -44.016 4.086  1.00 66.66  ? 130 TYR B CG  1 ? 
ATOM   3123 C CD1 . TYR B 1 98  ? -0.583  -43.804 2.825  1.00 65.42  ? 130 TYR B CD1 1 ? 
ATOM   3124 C CD2 . TYR B 1 98  ? 0.381   -42.906 4.803  1.00 64.53  ? 130 TYR B CD2 1 ? 
ATOM   3125 C CE1 . TYR B 1 98  ? -0.635  -42.539 2.268  1.00 72.02  ? 130 TYR B CE1 1 ? 
ATOM   3126 C CE2 . TYR B 1 98  ? 0.334   -41.636 4.258  1.00 67.85  ? 130 TYR B CE2 1 ? 
ATOM   3127 C CZ  . TYR B 1 98  ? -0.177  -41.452 2.987  1.00 68.65  ? 130 TYR B CZ  1 ? 
ATOM   3128 O OH  . TYR B 1 98  ? -0.241  -40.212 2.426  1.00 69.63  ? 130 TYR B OH  1 ? 
ATOM   3129 N N   . GLY B 1 99  ? -0.974  -48.186 5.870  1.00 69.79  ? 131 GLY B N   1 ? 
ATOM   3130 C CA  . GLY B 1 99  ? -0.792  -49.616 6.055  1.00 69.91  ? 131 GLY B CA  1 ? 
ATOM   3131 C C   . GLY B 1 99  ? -0.185  -49.911 7.422  1.00 72.37  ? 131 GLY B C   1 ? 
ATOM   3132 O O   . GLY B 1 99  ? 0.136   -48.982 8.160  1.00 78.02  ? 131 GLY B O   1 ? 
ATOM   3133 N N   . ALA B 1 100 ? -0.030  -51.202 7.741  1.00 78.48  ? 132 ALA B N   1 ? 
ATOM   3134 C CA  . ALA B 1 100 ? 0.659   -51.617 8.957  1.00 86.75  ? 132 ALA B CA  1 ? 
ATOM   3135 C C   . ALA B 1 100 ? 1.569   -52.821 8.702  1.00 81.18  ? 132 ALA B C   1 ? 
ATOM   3136 O O   . ALA B 1 100 ? 1.490   -53.465 7.660  1.00 78.96  ? 132 ALA B O   1 ? 
ATOM   3137 C CB  . ALA B 1 100 ? -0.351  -51.916 10.043 1.00 82.65  ? 132 ALA B CB  1 ? 
ATOM   3138 N N   . PHE B 1 101 ? 2.434   -53.117 9.680  1.00 85.74  ? 133 PHE B N   1 ? 
ATOM   3139 C CA  . PHE B 1 101 ? 3.376   -54.222 9.591  1.00 85.93  ? 133 PHE B CA  1 ? 
ATOM   3140 C C   . PHE B 1 101 ? 4.112   -54.395 10.918 1.00 91.99  ? 133 PHE B C   1 ? 
ATOM   3141 O O   . PHE B 1 101 ? 4.207   -53.449 11.692 1.00 89.93  ? 133 PHE B O   1 ? 
ATOM   3142 C CB  . PHE B 1 101 ? 4.399   -53.963 8.483  1.00 78.23  ? 133 PHE B CB  1 ? 
ATOM   3143 C CG  . PHE B 1 101 ? 5.318   -52.775 8.735  1.00 85.69  ? 133 PHE B CG  1 ? 
ATOM   3144 C CD1 . PHE B 1 101 ? 6.527   -52.935 9.403  1.00 83.79  ? 133 PHE B CD1 1 ? 
ATOM   3145 C CD2 . PHE B 1 101 ? 4.989   -51.502 8.277  1.00 90.04  ? 133 PHE B CD2 1 ? 
ATOM   3146 C CE1 . PHE B 1 101 ? 7.377   -51.857 9.608  1.00 76.19  ? 133 PHE B CE1 1 ? 
ATOM   3147 C CE2 . PHE B 1 101 ? 5.845   -50.428 8.486  1.00 84.84  ? 133 PHE B CE2 1 ? 
ATOM   3148 C CZ  . PHE B 1 101 ? 7.036   -50.611 9.147  1.00 81.21  ? 133 PHE B CZ  1 ? 
ATOM   3149 N N   . TYR B 1 102 ? 4.696   -55.587 11.123 1.00 106.58 ? 134 TYR B N   1 ? 
ATOM   3150 C CA  . TYR B 1 102 ? 5.417   -55.933 12.342 1.00 105.67 ? 134 TYR B CA  1 ? 
ATOM   3151 C C   . TYR B 1 102 ? 6.915   -56.091 12.075 1.00 104.35 ? 134 TYR B C   1 ? 
ATOM   3152 O O   . TYR B 1 102 ? 7.316   -56.603 11.035 1.00 111.00 ? 134 TYR B O   1 ? 
ATOM   3153 C CB  . TYR B 1 102 ? 4.834   -57.245 12.871 1.00 110.85 ? 134 TYR B CB  1 ? 
ATOM   3154 C CG  . TYR B 1 102 ? 5.464   -57.766 14.156 1.00 125.03 ? 134 TYR B CG  1 ? 
ATOM   3155 C CD1 . TYR B 1 102 ? 6.658   -58.481 14.133 1.00 127.27 ? 134 TYR B CD1 1 ? 
ATOM   3156 C CD2 . TYR B 1 102 ? 4.850   -57.567 15.390 1.00 127.31 ? 134 TYR B CD2 1 ? 
ATOM   3157 C CE1 . TYR B 1 102 ? 7.232   -58.963 15.298 1.00 130.64 ? 134 TYR B CE1 1 ? 
ATOM   3158 C CE2 . TYR B 1 102 ? 5.412   -58.049 16.561 1.00 129.30 ? 134 TYR B CE2 1 ? 
ATOM   3159 C CZ  . TYR B 1 102 ? 6.602   -58.753 16.512 1.00 133.13 ? 134 TYR B CZ  1 ? 
ATOM   3160 O OH  . TYR B 1 102 ? 7.156   -59.237 17.659 1.00 140.17 ? 134 TYR B OH  1 ? 
ATOM   3161 N N   . SER B 1 103 ? 7.737   -55.673 13.045 1.00 108.67 ? 135 SER B N   1 ? 
ATOM   3162 C CA  . SER B 1 103 ? 9.166   -55.950 13.039 1.00 117.85 ? 135 SER B CA  1 ? 
ATOM   3163 C C   . SER B 1 103 ? 9.812   -55.411 14.317 1.00 124.57 ? 135 SER B C   1 ? 
ATOM   3164 O O   . SER B 1 103 ? 9.407   -54.365 14.823 1.00 126.32 ? 135 SER B O   1 ? 
ATOM   3165 C CB  . SER B 1 103 ? 9.844   -55.390 11.812 1.00 116.26 ? 135 SER B CB  1 ? 
ATOM   3166 O OG  . SER B 1 103 ? 9.568   -54.005 11.664 1.00 119.09 ? 135 SER B OG  1 ? 
ATOM   3167 N N   . ASP B 1 104 ? 10.817  -56.143 14.824 1.00 125.75 ? 136 ASP B N   1 ? 
ATOM   3168 C CA  . ASP B 1 104 ? 11.526  -55.796 16.049 1.00 120.48 ? 136 ASP B CA  1 ? 
ATOM   3169 C C   . ASP B 1 104 ? 10.599  -55.912 17.258 1.00 111.16 ? 136 ASP B C   1 ? 
ATOM   3170 O O   . ASP B 1 104 ? 10.779  -55.200 18.242 1.00 110.56 ? 136 ASP B O   1 ? 
ATOM   3171 C CB  . ASP B 1 104 ? 12.119  -54.393 15.997 1.00 129.41 ? 136 ASP B CB  1 ? 
ATOM   3172 C CG  . ASP B 1 104 ? 13.026  -54.099 14.811 1.00 137.69 ? 136 ASP B CG  1 ? 
ATOM   3173 O OD1 . ASP B 1 104 ? 14.226  -54.443 14.887 1.00 133.93 ? 136 ASP B OD1 1 ? 
ATOM   3174 O OD2 . ASP B 1 104 ? 12.519  -53.543 13.814 1.00 146.95 ? 136 ASP B OD2 1 ? 
ATOM   3175 N N   . GLY B 1 105 ? 9.611   -56.810 17.196 1.00 104.76 ? 137 GLY B N   1 ? 
ATOM   3176 C CA  . GLY B 1 105 ? 8.664   -56.951 18.290 1.00 103.47 ? 137 GLY B CA  1 ? 
ATOM   3177 C C   . GLY B 1 105 ? 7.729   -55.748 18.415 1.00 111.82 ? 137 GLY B C   1 ? 
ATOM   3178 O O   . GLY B 1 105 ? 7.199   -55.506 19.497 1.00 117.75 ? 137 GLY B O   1 ? 
ATOM   3179 N N   . GLU B 1 106 ? 7.516   -55.014 17.308 1.00 112.36 ? 138 GLU B N   1 ? 
ATOM   3180 C CA  . GLU B 1 106 ? 6.751   -53.772 17.326 1.00 109.97 ? 138 GLU B CA  1 ? 
ATOM   3181 C C   . GLU B 1 106 ? 5.809   -53.681 16.121 1.00 106.94 ? 138 GLU B C   1 ? 
ATOM   3182 O O   . GLU B 1 106 ? 6.259   -53.693 14.972 1.00 93.09  ? 138 GLU B O   1 ? 
ATOM   3183 C CB  . GLU B 1 106 ? 7.666   -52.543 17.341 1.00 116.32 ? 138 GLU B CB  1 ? 
ATOM   3184 C CG  . GLU B 1 106 ? 8.580   -52.466 18.563 1.00 123.31 ? 138 GLU B CG  1 ? 
ATOM   3185 C CD  . GLU B 1 106 ? 9.052   -51.076 18.964 1.00 128.31 ? 138 GLU B CD  1 ? 
ATOM   3186 O OE1 . GLU B 1 106 ? 8.243   -50.356 19.586 1.00 134.59 ? 138 GLU B OE1 1 ? 
ATOM   3187 O OE2 . GLU B 1 106 ? 10.212  -50.708 18.668 1.00 120.10 ? 138 GLU B OE2 1 ? 
ATOM   3188 N N   . ILE B 1 107 ? 4.502   -53.543 16.409 1.00 105.33 ? 139 ILE B N   1 ? 
ATOM   3189 C CA  . ILE B 1 107 ? 3.494   -53.197 15.413 1.00 99.47  ? 139 ILE B CA  1 ? 
ATOM   3190 C C   . ILE B 1 107 ? 3.685   -51.746 14.977 1.00 93.52  ? 139 ILE B C   1 ? 
ATOM   3191 O O   . ILE B 1 107 ? 3.891   -50.867 15.808 1.00 100.16 ? 139 ILE B O   1 ? 
ATOM   3192 C CB  . ILE B 1 107 ? 2.068   -53.377 15.964 1.00 100.41 ? 139 ILE B CB  1 ? 
ATOM   3193 C CG1 . ILE B 1 107 ? 1.755   -54.828 16.342 1.00 109.76 ? 139 ILE B CG1 1 ? 
ATOM   3194 C CG2 . ILE B 1 107 ? 1.047   -52.810 14.976 1.00 95.34  ? 139 ILE B CG2 1 ? 
ATOM   3195 C CD1 . ILE B 1 107 ? 1.457   -55.743 15.167 1.00 109.04 ? 139 ILE B CD1 1 ? 
ATOM   3196 N N   . SER B 1 108 ? 3.557   -51.497 13.673 1.00 88.49  ? 140 SER B N   1 ? 
ATOM   3197 C CA  . SER B 1 108 ? 3.628   -50.148 13.142 1.00 87.66  ? 140 SER B CA  1 ? 
ATOM   3198 C C   . SER B 1 108 ? 2.350   -49.830 12.376 1.00 90.00  ? 140 SER B C   1 ? 
ATOM   3199 O O   . SER B 1 108 ? 1.917   -50.623 11.541 1.00 80.86  ? 140 SER B O   1 ? 
ATOM   3200 C CB  . SER B 1 108 ? 4.837   -49.959 12.276 1.00 83.32  ? 140 SER B CB  1 ? 
ATOM   3201 O OG  . SER B 1 108 ? 5.979   -49.718 13.080 1.00 89.29  ? 140 SER B OG  1 ? 
ATOM   3202 N N   . ILE B 1 109 ? 1.757   -48.670 12.685 1.00 90.42  ? 141 ILE B N   1 ? 
ATOM   3203 C CA  . ILE B 1 109 ? 0.596   -48.184 11.964 1.00 88.31  ? 141 ILE B CA  1 ? 
ATOM   3204 C C   . ILE B 1 109 ? 0.988   -46.894 11.251 1.00 83.65  ? 141 ILE B C   1 ? 
ATOM   3205 O O   . ILE B 1 109 ? 1.376   -45.920 11.891 1.00 85.87  ? 141 ILE B O   1 ? 
ATOM   3206 C CB  . ILE B 1 109 ? -0.606  -48.013 12.905 1.00 94.24  ? 141 ILE B CB  1 ? 
ATOM   3207 C CG1 . ILE B 1 109 ? -0.852  -49.283 13.707 1.00 95.90  ? 141 ILE B CG1 1 ? 
ATOM   3208 C CG2 . ILE B 1 109 ? -1.856  -47.603 12.128 1.00 103.65 ? 141 ILE B CG2 1 ? 
ATOM   3209 C CD1 . ILE B 1 109 ? -0.032  -49.381 14.977 1.00 107.11 ? 141 ILE B CD1 1 ? 
ATOM   3210 N N   . CYS B 1 110 ? 0.907   -46.933 9.916  1.00 76.70  ? 142 CYS B N   1 ? 
ATOM   3211 C CA  . CYS B 1 110 ? 1.304   -45.826 9.066  1.00 82.61  ? 142 CYS B CA  1 ? 
ATOM   3212 C C   . CYS B 1 110 ? 0.059   -45.113 8.557  1.00 80.29  ? 142 CYS B C   1 ? 
ATOM   3213 O O   . CYS B 1 110 ? -0.802  -45.723 7.931  1.00 84.86  ? 142 CYS B O   1 ? 
ATOM   3214 C CB  . CYS B 1 110 ? 2.158   -46.292 7.894  1.00 87.70  ? 142 CYS B CB  1 ? 
ATOM   3215 S SG  . CYS B 1 110 ? 3.732   -47.014 8.421  1.00 83.76  ? 142 CYS B SG  1 ? 
ATOM   3216 N N   . MET B 1 111 ? 0.017   -43.806 8.815  1.00 80.54  ? 143 MET B N   1 ? 
ATOM   3217 C CA  . MET B 1 111 ? -1.185  -43.008 8.703  1.00 69.38  ? 143 MET B CA  1 ? 
ATOM   3218 C C   . MET B 1 111 ? -0.831  -41.730 7.961  1.00 62.96  ? 143 MET B C   1 ? 
ATOM   3219 O O   . MET B 1 111 ? 0.344   -41.399 7.815  1.00 71.60  ? 143 MET B O   1 ? 
ATOM   3220 C CB  . MET B 1 111 ? -1.699  -42.655 10.103 1.00 77.18  ? 143 MET B CB  1 ? 
ATOM   3221 C CG  . MET B 1 111 ? -1.965  -43.853 10.992 1.00 76.17  ? 143 MET B CG  1 ? 
ATOM   3222 S SD  . MET B 1 111 ? -3.657  -44.462 10.859 1.00 87.53  ? 143 MET B SD  1 ? 
ATOM   3223 C CE  . MET B 1 111 ? -4.236  -44.020 12.495 1.00 76.06  ? 143 MET B CE  1 ? 
ATOM   3224 N N   . GLU B 1 112 ? -1.857  -41.021 7.493  1.00 67.80  ? 144 GLU B N   1 ? 
ATOM   3225 C CA  . GLU B 1 112 ? -1.686  -39.737 6.830  1.00 69.40  ? 144 GLU B CA  1 ? 
ATOM   3226 C C   . GLU B 1 112 ? -0.994  -38.780 7.793  1.00 72.49  ? 144 GLU B C   1 ? 
ATOM   3227 O O   . GLU B 1 112 ? -1.178  -38.874 9.008  1.00 76.14  ? 144 GLU B O   1 ? 
ATOM   3228 C CB  . GLU B 1 112 ? -3.093  -39.280 6.448  1.00 73.43  ? 144 GLU B CB  1 ? 
ATOM   3229 C CG  . GLU B 1 112 ? -3.194  -37.876 5.863  1.00 77.77  ? 144 GLU B CG  1 ? 
ATOM   3230 C CD  . GLU B 1 112 ? -4.630  -37.377 5.756  1.00 77.85  ? 144 GLU B CD  1 ? 
ATOM   3231 O OE1 . GLU B 1 112 ? -5.540  -38.113 6.191  1.00 82.69  ? 144 GLU B OE1 1 ? 
ATOM   3232 O OE2 . GLU B 1 112 ? -4.854  -36.259 5.244  1.00 72.99  ? 144 GLU B OE2 1 ? 
ATOM   3233 N N   . HIS B 1 113 ? -0.190  -37.868 7.244  1.00 78.82  ? 145 HIS B N   1 ? 
ATOM   3234 C CA  . HIS B 1 113 ? 0.504   -36.893 8.067  1.00 73.85  ? 145 HIS B CA  1 ? 
ATOM   3235 C C   . HIS B 1 113 ? -0.335  -35.628 8.190  1.00 75.01  ? 145 HIS B C   1 ? 
ATOM   3236 O O   . HIS B 1 113 ? -0.470  -34.874 7.215  1.00 63.52  ? 145 HIS B O   1 ? 
ATOM   3237 C CB  . HIS B 1 113 ? 1.873   -36.486 7.505  1.00 71.85  ? 145 HIS B CB  1 ? 
ATOM   3238 C CG  . HIS B 1 113 ? 2.562   -35.510 8.417  1.00 68.79  ? 145 HIS B CG  1 ? 
ATOM   3239 N ND1 . HIS B 1 113 ? 2.945   -34.239 8.041  1.00 62.91  ? 145 HIS B ND1 1 ? 
ATOM   3240 C CD2 . HIS B 1 113 ? 2.852   -35.616 9.728  1.00 63.04  ? 145 HIS B CD2 1 ? 
ATOM   3241 C CE1 . HIS B 1 113 ? 3.478   -33.622 9.087  1.00 68.65  ? 145 HIS B CE1 1 ? 
ATOM   3242 N NE2 . HIS B 1 113 ? 3.447   -34.446 10.115 1.00 69.81  ? 145 HIS B NE2 1 ? 
ATOM   3243 N N   . MET B 1 114 ? -0.813  -35.386 9.422  1.00 67.75  ? 146 MET B N   1 ? 
ATOM   3244 C CA  . MET B 1 114 ? -1.554  -34.179 9.755  1.00 66.95  ? 146 MET B CA  1 ? 
ATOM   3245 C C   . MET B 1 114 ? -0.622  -33.144 10.404 1.00 66.92  ? 146 MET B C   1 ? 
ATOM   3246 O O   . MET B 1 114 ? -0.343  -33.203 11.602 1.00 69.65  ? 146 MET B O   1 ? 
ATOM   3247 C CB  . MET B 1 114 ? -2.739  -34.559 10.651 1.00 69.63  ? 146 MET B CB  1 ? 
ATOM   3248 C CG  . MET B 1 114 ? -3.774  -35.467 9.962  1.00 67.93  ? 146 MET B CG  1 ? 
ATOM   3249 S SD  . MET B 1 114 ? -4.717  -34.691 8.630  1.00 75.97  ? 146 MET B SD  1 ? 
ATOM   3250 C CE  . MET B 1 114 ? -5.769  -33.752 9.747  1.00 70.59  ? 146 MET B CE  1 ? 
ATOM   3251 N N   . ASP B 1 115 ? -0.190  -32.154 9.608  1.00 60.71  ? 147 ASP B N   1 ? 
ATOM   3252 C CA  . ASP B 1 115 ? 0.903   -31.253 9.960  1.00 69.13  ? 147 ASP B CA  1 ? 
ATOM   3253 C C   . ASP B 1 115 ? 0.578   -30.326 11.138 1.00 73.62  ? 147 ASP B C   1 ? 
ATOM   3254 O O   . ASP B 1 115 ? 1.493   -29.718 11.704 1.00 72.20  ? 147 ASP B O   1 ? 
ATOM   3255 C CB  . ASP B 1 115 ? 1.368   -30.438 8.760  1.00 63.99  ? 147 ASP B CB  1 ? 
ATOM   3256 C CG  . ASP B 1 115 ? 0.341   -29.530 8.104  1.00 72.05  ? 147 ASP B CG  1 ? 
ATOM   3257 O OD1 . ASP B 1 115 ? -0.792  -29.465 8.614  1.00 74.27  ? 147 ASP B OD1 1 ? 
ATOM   3258 O OD2 . ASP B 1 115 ? 0.702   -28.871 7.102  1.00 74.37  ? 147 ASP B OD2 1 ? 
ATOM   3259 N N   . GLY B 1 116 ? -0.713  -30.227 11.494 1.00 67.45  ? 148 GLY B N   1 ? 
ATOM   3260 C CA  . GLY B 1 116 ? -1.183  -29.399 12.595 1.00 58.63  ? 148 GLY B CA  1 ? 
ATOM   3261 C C   . GLY B 1 116 ? -1.140  -30.097 13.953 1.00 57.45  ? 148 GLY B C   1 ? 
ATOM   3262 O O   . GLY B 1 116 ? -1.264  -29.430 14.975 1.00 63.11  ? 148 GLY B O   1 ? 
ATOM   3263 N N   . GLY B 1 117 ? -0.993  -31.429 13.976 1.00 59.46  ? 149 GLY B N   1 ? 
ATOM   3264 C CA  . GLY B 1 117 ? -0.975  -32.175 15.230 1.00 62.96  ? 149 GLY B CA  1 ? 
ATOM   3265 C C   . GLY B 1 117 ? -2.371  -32.443 15.805 1.00 65.65  ? 149 GLY B C   1 ? 
ATOM   3266 O O   . GLY B 1 117 ? -3.384  -32.243 15.135 1.00 64.61  ? 149 GLY B O   1 ? 
ATOM   3267 N N   . SER B 1 118 ? -2.396  -32.972 17.035 1.00 61.78  ? 150 SER B N   1 ? 
ATOM   3268 C CA  . SER B 1 118 ? -3.628  -33.170 17.777 1.00 65.23  ? 150 SER B CA  1 ? 
ATOM   3269 C C   . SER B 1 118 ? -4.058  -31.863 18.433 1.00 66.17  ? 150 SER B C   1 ? 
ATOM   3270 O O   . SER B 1 118 ? -3.225  -31.038 18.798 1.00 61.58  ? 150 SER B O   1 ? 
ATOM   3271 C CB  . SER B 1 118 ? -3.473  -34.199 18.853 1.00 67.21  ? 150 SER B CB  1 ? 
ATOM   3272 O OG  . SER B 1 118 ? -2.268  -34.928 18.704 1.00 87.90  ? 150 SER B OG  1 ? 
ATOM   3273 N N   . LEU B 1 119 ? -5.356  -31.738 18.705 1.00 60.21  ? 151 LEU B N   1 ? 
ATOM   3274 C CA  . LEU B 1 119 ? -5.849  -30.576 19.423 1.00 60.84  ? 151 LEU B CA  1 ? 
ATOM   3275 C C   . LEU B 1 119 ? -5.317  -30.525 20.861 1.00 57.55  ? 151 LEU B C   1 ? 
ATOM   3276 O O   . LEU B 1 119 ? -5.310  -29.454 21.457 1.00 65.33  ? 151 LEU B O   1 ? 
ATOM   3277 C CB  . LEU B 1 119 ? -7.373  -30.537 19.343 1.00 58.83  ? 151 LEU B CB  1 ? 
ATOM   3278 C CG  . LEU B 1 119 ? -7.948  -30.178 17.969 1.00 62.11  ? 151 LEU B CG  1 ? 
ATOM   3279 C CD1 . LEU B 1 119 ? -9.465  -30.154 18.022 1.00 62.91  ? 151 LEU B CD1 1 ? 
ATOM   3280 C CD2 . LEU B 1 119 ? -7.425  -28.846 17.449 1.00 61.31  ? 151 LEU B CD2 1 ? 
ATOM   3281 N N   . ASP B 1 120 ? -4.812  -31.625 21.428 1.00 57.75  ? 152 ASP B N   1 ? 
ATOM   3282 C CA  . ASP B 1 120 ? -4.181  -31.516 22.742 1.00 65.44  ? 152 ASP B CA  1 ? 
ATOM   3283 C C   . ASP B 1 120 ? -2.891  -30.707 22.618 1.00 62.48  ? 152 ASP B C   1 ? 
ATOM   3284 O O   . ASP B 1 120 ? -2.603  -29.859 23.459 1.00 57.45  ? 152 ASP B O   1 ? 
ATOM   3285 C CB  . ASP B 1 120 ? -3.935  -32.862 23.403 1.00 67.40  ? 152 ASP B CB  1 ? 
ATOM   3286 C CG  . ASP B 1 120 ? -2.852  -33.689 22.731 1.00 88.32  ? 152 ASP B CG  1 ? 
ATOM   3287 O OD1 . ASP B 1 120 ? -2.875  -33.757 21.478 1.00 87.29  ? 152 ASP B OD1 1 ? 
ATOM   3288 O OD2 . ASP B 1 120 ? -1.988  -34.236 23.461 1.00 98.66  ? 152 ASP B OD2 1 ? 
ATOM   3289 N N   . GLN B 1 121 ? -2.127  -30.954 21.550 1.00 60.02  ? 153 GLN B N   1 ? 
ATOM   3290 C CA  . GLN B 1 121 ? -0.900  -30.210 21.339 1.00 64.54  ? 153 GLN B CA  1 ? 
ATOM   3291 C C   . GLN B 1 121 ? -1.237  -28.761 20.984 1.00 58.77  ? 153 GLN B C   1 ? 
ATOM   3292 O O   . GLN B 1 121 ? -0.560  -27.847 21.425 1.00 62.03  ? 153 GLN B O   1 ? 
ATOM   3293 C CB  . GLN B 1 121 ? -0.018  -30.783 20.229 1.00 70.19  ? 153 GLN B CB  1 ? 
ATOM   3294 C CG  . GLN B 1 121 ? 0.340   -32.258 20.366 1.00 78.56  ? 153 GLN B CG  1 ? 
ATOM   3295 C CD  . GLN B 1 121 ? 0.746   -32.861 19.033 1.00 95.88  ? 153 GLN B CD  1 ? 
ATOM   3296 O OE1 . GLN B 1 121 ? 1.279   -32.177 18.147 1.00 92.17  ? 153 GLN B OE1 1 ? 
ATOM   3297 N NE2 . GLN B 1 121 ? 0.489   -34.152 18.869 1.00 101.95 ? 153 GLN B NE2 1 ? 
ATOM   3298 N N   . VAL B 1 122 ? -2.264  -28.549 20.157 1.00 57.78  ? 154 VAL B N   1 ? 
ATOM   3299 C CA  . VAL B 1 122 ? -2.647  -27.207 19.769 1.00 55.17  ? 154 VAL B CA  1 ? 
ATOM   3300 C C   . VAL B 1 122 ? -3.117  -26.429 20.996 1.00 54.98  ? 154 VAL B C   1 ? 
ATOM   3301 O O   . VAL B 1 122 ? -2.753  -25.267 21.169 1.00 54.55  ? 154 VAL B O   1 ? 
ATOM   3302 C CB  . VAL B 1 122 ? -3.714  -27.288 18.670 1.00 59.29  ? 154 VAL B CB  1 ? 
ATOM   3303 C CG1 . VAL B 1 122 ? -4.343  -25.930 18.357 1.00 58.19  ? 154 VAL B CG1 1 ? 
ATOM   3304 C CG2 . VAL B 1 122 ? -3.117  -27.898 17.416 1.00 59.79  ? 154 VAL B CG2 1 ? 
ATOM   3305 N N   . LEU B 1 123 ? -3.874  -27.099 21.868 1.00 51.99  ? 155 LEU B N   1 ? 
ATOM   3306 C CA  . LEU B 1 123 ? -4.422  -26.467 23.058 1.00 57.72  ? 155 LEU B CA  1 ? 
ATOM   3307 C C   . LEU B 1 123 ? -3.302  -25.896 23.928 1.00 60.55  ? 155 LEU B C   1 ? 
ATOM   3308 O O   . LEU B 1 123 ? -3.424  -24.784 24.446 1.00 57.02  ? 155 LEU B O   1 ? 
ATOM   3309 C CB  . LEU B 1 123 ? -5.298  -27.440 23.844 1.00 58.87  ? 155 LEU B CB  1 ? 
ATOM   3310 C CG  . LEU B 1 123 ? -6.050  -26.845 25.038 1.00 58.12  ? 155 LEU B CG  1 ? 
ATOM   3311 C CD1 . LEU B 1 123 ? -7.072  -25.802 24.620 1.00 61.12  ? 155 LEU B CD1 1 ? 
ATOM   3312 C CD2 . LEU B 1 123 ? -6.724  -27.966 25.779 1.00 56.79  ? 155 LEU B CD2 1 ? 
ATOM   3313 N N   . LYS B 1 124 ? -2.206  -26.647 24.068 1.00 65.99  ? 156 LYS B N   1 ? 
ATOM   3314 C CA  . LYS B 1 124 ? -1.070  -26.208 24.861 1.00 63.33  ? 156 LYS B CA  1 ? 
ATOM   3315 C C   . LYS B 1 124 ? -0.431  -24.986 24.212 1.00 56.99  ? 156 LYS B C   1 ? 
ATOM   3316 O O   . LYS B 1 124 ? -0.036  -24.050 24.891 1.00 63.40  ? 156 LYS B O   1 ? 
ATOM   3317 C CB  . LYS B 1 124 ? -0.093  -27.368 25.049 1.00 71.61  ? 156 LYS B CB  1 ? 
ATOM   3318 C CG  . LYS B 1 124 ? -0.548  -28.405 26.063 1.00 84.82  ? 156 LYS B CG  1 ? 
ATOM   3319 C CD  . LYS B 1 124 ? 0.030   -29.797 25.824 1.00 103.44 ? 156 LYS B CD  1 ? 
ATOM   3320 C CE  . LYS B 1 124 ? 1.510   -29.842 25.552 1.00 118.88 ? 156 LYS B CE  1 ? 
ATOM   3321 N NZ  . LYS B 1 124 ? 1.920   -31.178 25.108 1.00 126.99 ? 156 LYS B NZ  1 ? 
ATOM   3322 N N   . LYS B 1 125 ? -0.369  -24.947 22.890 1.00 57.87  ? 157 LYS B N   1 ? 
ATOM   3323 C CA  . LYS B 1 125 ? 0.103   -23.733 22.248 1.00 60.97  ? 157 LYS B CA  1 ? 
ATOM   3324 C C   . LYS B 1 125 ? -0.896  -22.576 22.401 1.00 57.42  ? 157 LYS B C   1 ? 
ATOM   3325 O O   . LYS B 1 125 ? -0.497  -21.423 22.448 1.00 63.57  ? 157 LYS B O   1 ? 
ATOM   3326 C CB  . LYS B 1 125 ? 0.420   -24.008 20.777 1.00 70.87  ? 157 LYS B CB  1 ? 
ATOM   3327 C CG  . LYS B 1 125 ? 1.886   -23.973 20.403 1.00 78.67  ? 157 LYS B CG  1 ? 
ATOM   3328 C CD  . LYS B 1 125 ? 2.792   -24.968 21.108 1.00 82.37  ? 157 LYS B CD  1 ? 
ATOM   3329 C CE  . LYS B 1 125 ? 4.189   -24.879 20.561 1.00 85.40  ? 157 LYS B CE  1 ? 
ATOM   3330 N NZ  . LYS B 1 125 ? 4.231   -25.304 19.154 1.00 90.11  ? 157 LYS B NZ  1 ? 
ATOM   3331 N N   . ALA B 1 126 ? -2.203  -22.846 22.439 1.00 56.72  ? 158 ALA B N   1 ? 
ATOM   3332 C CA  . ALA B 1 126 ? -3.189  -21.776 22.323 1.00 52.36  ? 158 ALA B CA  1 ? 
ATOM   3333 C C   . ALA B 1 126 ? -3.613  -21.219 23.685 1.00 52.92  ? 158 ALA B C   1 ? 
ATOM   3334 O O   . ALA B 1 126 ? -3.942  -20.042 23.792 1.00 53.24  ? 158 ALA B O   1 ? 
ATOM   3335 C CB  . ALA B 1 126 ? -4.386  -22.283 21.553 1.00 56.65  ? 158 ALA B CB  1 ? 
ATOM   3336 N N   . GLY B 1 127 ? -3.584  -22.064 24.721 1.00 58.09  ? 159 GLY B N   1 ? 
ATOM   3337 C CA  . GLY B 1 127 ? -4.175  -21.763 26.016 1.00 57.27  ? 159 GLY B CA  1 ? 
ATOM   3338 C C   . GLY B 1 127 ? -5.648  -22.180 26.016 1.00 59.87  ? 159 GLY B C   1 ? 
ATOM   3339 O O   . GLY B 1 127 ? -6.062  -23.097 26.721 1.00 58.52  ? 159 GLY B O   1 ? 
ATOM   3340 N N   . ARG B 1 128 ? -6.421  -21.501 25.173 1.00 56.74  ? 160 ARG B N   1 ? 
ATOM   3341 C CA  . ARG B 1 128 ? -7.825  -21.797 24.959 1.00 59.26  ? 160 ARG B CA  1 ? 
ATOM   3342 C C   . ARG B 1 128 ? -8.067  -21.753 23.457 1.00 54.67  ? 160 ARG B C   1 ? 
ATOM   3343 O O   . ARG B 1 128 ? -7.395  -21.009 22.749 1.00 59.08  ? 160 ARG B O   1 ? 
ATOM   3344 C CB  . ARG B 1 128 ? -8.704  -20.750 25.655 1.00 59.82  ? 160 ARG B CB  1 ? 
ATOM   3345 C CG  . ARG B 1 128 ? -8.623  -20.794 27.171 1.00 65.16  ? 160 ARG B CG  1 ? 
ATOM   3346 C CD  . ARG B 1 128 ? -9.707  -19.961 27.809 1.00 64.64  ? 160 ARG B CD  1 ? 
ATOM   3347 N NE  . ARG B 1 128 ? -9.479  -18.516 27.747 1.00 67.46  ? 160 ARG B NE  1 ? 
ATOM   3348 C CZ  . ARG B 1 128 ? -8.983  -17.799 28.751 1.00 76.79  ? 160 ARG B CZ  1 ? 
ATOM   3349 N NH1 . ARG B 1 128 ? -8.469  -18.401 29.811 1.00 89.38  ? 160 ARG B NH1 1 ? 
ATOM   3350 N NH2 . ARG B 1 128 ? -8.953  -16.479 28.683 1.00 74.27  ? 160 ARG B NH2 1 ? 
ATOM   3351 N N   . ILE B 1 129 ? -9.019  -22.548 22.975 1.00 54.33  ? 161 ILE B N   1 ? 
ATOM   3352 C CA  . ILE B 1 129 ? -9.373  -22.512 21.567 1.00 54.49  ? 161 ILE B CA  1 ? 
ATOM   3353 C C   . ILE B 1 129 ? -10.682 -21.733 21.427 1.00 54.80  ? 161 ILE B C   1 ? 
ATOM   3354 O O   . ILE B 1 129 ? -11.686 -22.024 22.082 1.00 55.47  ? 161 ILE B O   1 ? 
ATOM   3355 C CB  . ILE B 1 129 ? -9.401  -23.936 20.989 1.00 56.26  ? 161 ILE B CB  1 ? 
ATOM   3356 C CG1 . ILE B 1 129 ? -8.017  -24.573 21.150 1.00 53.59  ? 161 ILE B CG1 1 ? 
ATOM   3357 C CG2 . ILE B 1 129 ? -9.872  -23.961 19.530 1.00 55.92  ? 161 ILE B CG2 1 ? 
ATOM   3358 C CD1 . ILE B 1 129 ? -7.954  -26.037 20.775 1.00 55.46  ? 161 ILE B CD1 1 ? 
ATOM   3359 N N   . PRO B 1 130 ? -10.701 -20.672 20.595 1.00 53.43  ? 162 PRO B N   1 ? 
ATOM   3360 C CA  . PRO B 1 130 ? -11.869 -19.800 20.513 1.00 53.59  ? 162 PRO B CA  1 ? 
ATOM   3361 C C   . PRO B 1 130 ? -13.097 -20.536 19.980 1.00 51.19  ? 162 PRO B C   1 ? 
ATOM   3362 O O   . PRO B 1 130 ? -12.979 -21.519 19.259 1.00 48.61  ? 162 PRO B O   1 ? 
ATOM   3363 C CB  . PRO B 1 130 ? -11.392 -18.655 19.609 1.00 51.94  ? 162 PRO B CB  1 ? 
ATOM   3364 C CG  . PRO B 1 130 ? -10.304 -19.260 18.774 1.00 53.88  ? 162 PRO B CG  1 ? 
ATOM   3365 C CD  . PRO B 1 130 ? -9.627  -20.267 19.683 1.00 56.03  ? 162 PRO B CD  1 ? 
ATOM   3366 N N   . GLU B 1 131 ? -14.270 -20.043 20.386 1.00 63.46  ? 163 GLU B N   1 ? 
ATOM   3367 C CA  . GLU B 1 131 ? -15.565 -20.664 20.140 1.00 61.20  ? 163 GLU B CA  1 ? 
ATOM   3368 C C   . GLU B 1 131 ? -15.779 -20.971 18.662 1.00 53.01  ? 163 GLU B C   1 ? 
ATOM   3369 O O   . GLU B 1 131 ? -16.251 -22.051 18.343 1.00 57.52  ? 163 GLU B O   1 ? 
ATOM   3370 C CB  . GLU B 1 131 ? -16.665 -19.736 20.648 1.00 67.40  ? 163 GLU B CB  1 ? 
ATOM   3371 C CG  . GLU B 1 131 ? -18.066 -20.325 20.539 1.00 68.62  ? 163 GLU B CG  1 ? 
ATOM   3372 C CD  . GLU B 1 131 ? -19.128 -19.484 21.227 1.00 68.73  ? 163 GLU B CD  1 ? 
ATOM   3373 O OE1 . GLU B 1 131 ? -18.861 -18.769 22.225 1.00 64.98  ? 163 GLU B OE1 1 ? 
ATOM   3374 O OE2 . GLU B 1 131 ? -20.248 -19.534 20.695 1.00 64.49  ? 163 GLU B OE2 1 ? 
ATOM   3375 N N   . GLN B 1 132 ? -15.410 -20.048 17.767 1.00 53.27  ? 164 GLN B N   1 ? 
ATOM   3376 C CA  . GLN B 1 132 ? -15.672 -20.241 16.349 1.00 55.48  ? 164 GLN B CA  1 ? 
ATOM   3377 C C   . GLN B 1 132 ? -14.810 -21.355 15.775 1.00 53.52  ? 164 GLN B C   1 ? 
ATOM   3378 O O   . GLN B 1 132 ? -15.241 -22.031 14.848 1.00 55.54  ? 164 GLN B O   1 ? 
ATOM   3379 C CB  . GLN B 1 132 ? -15.425 -18.991 15.516 1.00 64.48  ? 164 GLN B CB  1 ? 
ATOM   3380 C CG  . GLN B 1 132 ? -16.515 -17.938 15.678 1.00 70.42  ? 164 GLN B CG  1 ? 
ATOM   3381 C CD  . GLN B 1 132 ? -16.377 -16.787 14.706 1.00 73.64  ? 164 GLN B CD  1 ? 
ATOM   3382 O OE1 . GLN B 1 132 ? -15.377 -16.653 13.993 1.00 79.68  ? 164 GLN B OE1 1 ? 
ATOM   3383 N NE2 . GLN B 1 132 ? -17.385 -15.928 14.688 1.00 82.90  ? 164 GLN B NE2 1 ? 
ATOM   3384 N N   . ILE B 1 133 ? -13.584 -21.508 16.290 1.00 51.38  ? 165 ILE B N   1 ? 
ATOM   3385 C CA  . ILE B 1 133 ? -12.742 -22.616 15.880 1.00 47.91  ? 165 ILE B CA  1 ? 
ATOM   3386 C C   . ILE B 1 133 ? -13.397 -23.920 16.318 1.00 51.09  ? 165 ILE B C   1 ? 
ATOM   3387 O O   . ILE B 1 133 ? -13.472 -24.864 15.533 1.00 54.24  ? 165 ILE B O   1 ? 
ATOM   3388 C CB  . ILE B 1 133 ? -11.315 -22.480 16.434 1.00 50.42  ? 165 ILE B CB  1 ? 
ATOM   3389 C CG1 . ILE B 1 133 ? -10.586 -21.244 15.905 1.00 47.96  ? 165 ILE B CG1 1 ? 
ATOM   3390 C CG2 . ILE B 1 133 ? -10.531 -23.751 16.134 1.00 47.00  ? 165 ILE B CG2 1 ? 
ATOM   3391 C CD1 . ILE B 1 133 ? -10.208 -21.342 14.434 1.00 51.82  ? 165 ILE B CD1 1 ? 
ATOM   3392 N N   . LEU B 1 134 ? -13.894 -23.952 17.560 1.00 50.28  ? 166 LEU B N   1 ? 
ATOM   3393 C CA  . LEU B 1 134 ? -14.503 -25.147 18.136 1.00 53.57  ? 166 LEU B CA  1 ? 
ATOM   3394 C C   . LEU B 1 134 ? -15.788 -25.563 17.408 1.00 59.55  ? 166 LEU B C   1 ? 
ATOM   3395 O O   . LEU B 1 134 ? -16.175 -26.731 17.450 1.00 65.94  ? 166 LEU B O   1 ? 
ATOM   3396 C CB  . LEU B 1 134 ? -14.781 -24.908 19.623 1.00 51.56  ? 166 LEU B CB  1 ? 
ATOM   3397 C CG  . LEU B 1 134 ? -13.556 -24.878 20.540 1.00 52.72  ? 166 LEU B CG  1 ? 
ATOM   3398 C CD1 . LEU B 1 134 ? -13.876 -24.655 22.030 1.00 47.66  ? 166 LEU B CD1 1 ? 
ATOM   3399 C CD2 . LEU B 1 134 ? -12.782 -26.165 20.309 1.00 50.23  ? 166 LEU B CD2 1 ? 
ATOM   3400 N N   . GLY B 1 135 ? -16.487 -24.610 16.792 1.00 56.04  ? 167 GLY B N   1 ? 
ATOM   3401 C CA  . GLY B 1 135 ? -17.656 -24.931 15.995 1.00 54.16  ? 167 GLY B CA  1 ? 
ATOM   3402 C C   . GLY B 1 135 ? -17.262 -25.679 14.731 1.00 52.11  ? 167 GLY B C   1 ? 
ATOM   3403 O O   . GLY B 1 135 ? -17.913 -26.643 14.364 1.00 58.32  ? 167 GLY B O   1 ? 
ATOM   3404 N N   . LYS B 1 136 ? -16.182 -25.258 14.071 1.00 58.29  ? 168 LYS B N   1 ? 
ATOM   3405 C CA  . LYS B 1 136 ? -15.661 -26.033 12.955 1.00 61.28  ? 168 LYS B CA  1 ? 
ATOM   3406 C C   . LYS B 1 136 ? -15.242 -27.424 13.446 1.00 67.42  ? 168 LYS B C   1 ? 
ATOM   3407 O O   . LYS B 1 136 ? -15.482 -28.425 12.772 1.00 71.86  ? 168 LYS B O   1 ? 
ATOM   3408 C CB  . LYS B 1 136 ? -14.495 -25.321 12.265 1.00 68.74  ? 168 LYS B CB  1 ? 
ATOM   3409 C CG  . LYS B 1 136 ? -14.784 -23.956 11.659 1.00 70.74  ? 168 LYS B CG  1 ? 
ATOM   3410 C CD  . LYS B 1 136 ? -16.045 -23.940 10.804 1.00 74.72  ? 168 LYS B CD  1 ? 
ATOM   3411 C CE  . LYS B 1 136 ? -16.246 -22.611 10.159 1.00 75.27  ? 168 LYS B CE  1 ? 
ATOM   3412 N NZ  . LYS B 1 136 ? -17.560 -22.512 9.522  1.00 71.19  ? 168 LYS B NZ  1 ? 
ATOM   3413 N N   . VAL B 1 137 ? -14.628 -27.505 14.633 1.00 61.38  ? 169 VAL B N   1 ? 
ATOM   3414 C CA  . VAL B 1 137 ? -14.191 -28.792 15.158 1.00 62.09  ? 169 VAL B CA  1 ? 
ATOM   3415 C C   . VAL B 1 137 ? -15.415 -29.673 15.384 1.00 58.70  ? 169 VAL B C   1 ? 
ATOM   3416 O O   . VAL B 1 137 ? -15.387 -30.870 15.083 1.00 55.35  ? 169 VAL B O   1 ? 
ATOM   3417 C CB  . VAL B 1 137 ? -13.363 -28.653 16.453 1.00 58.63  ? 169 VAL B CB  1 ? 
ATOM   3418 C CG1 . VAL B 1 137 ? -13.106 -29.994 17.136 1.00 54.02  ? 169 VAL B CG1 1 ? 
ATOM   3419 C CG2 . VAL B 1 137 ? -12.050 -27.935 16.191 1.00 66.86  ? 169 VAL B CG2 1 ? 
ATOM   3420 N N   . SER B 1 138 ? -16.468 -29.052 15.933 1.00 57.83  ? 170 SER B N   1 ? 
ATOM   3421 C CA  . SER B 1 138 ? -17.684 -29.742 16.335 1.00 57.95  ? 170 SER B CA  1 ? 
ATOM   3422 C C   . SER B 1 138 ? -18.356 -30.373 15.123 1.00 57.46  ? 170 SER B C   1 ? 
ATOM   3423 O O   . SER B 1 138 ? -18.808 -31.508 15.189 1.00 58.99  ? 170 SER B O   1 ? 
ATOM   3424 C CB  . SER B 1 138 ? -18.640 -28.817 17.060 1.00 59.80  ? 170 SER B CB  1 ? 
ATOM   3425 O OG  . SER B 1 138 ? -18.280 -28.650 18.427 1.00 57.76  ? 170 SER B OG  1 ? 
ATOM   3426 N N   . ILE B 1 139 ? -18.427 -29.627 14.025 1.00 56.18  ? 171 ILE B N   1 ? 
ATOM   3427 C CA  . ILE B 1 139 ? -19.009 -30.140 12.798 1.00 62.60  ? 171 ILE B CA  1 ? 
ATOM   3428 C C   . ILE B 1 139 ? -18.237 -31.384 12.359 1.00 61.11  ? 171 ILE B C   1 ? 
ATOM   3429 O O   . ILE B 1 139 ? -18.811 -32.463 12.214 1.00 65.25  ? 171 ILE B O   1 ? 
ATOM   3430 C CB  . ILE B 1 139 ? -19.026 -29.029 11.734 1.00 70.54  ? 171 ILE B CB  1 ? 
ATOM   3431 C CG1 . ILE B 1 139 ? -20.056 -27.956 12.107 1.00 73.01  ? 171 ILE B CG1 1 ? 
ATOM   3432 C CG2 . ILE B 1 139 ? -19.270 -29.585 10.333 1.00 68.29  ? 171 ILE B CG2 1 ? 
ATOM   3433 C CD1 . ILE B 1 139 ? -19.821 -26.615 11.437 1.00 75.27  ? 171 ILE B CD1 1 ? 
ATOM   3434 N N   . ALA B 1 140 ? -16.924 -31.230 12.182 1.00 65.64  ? 172 ALA B N   1 ? 
ATOM   3435 C CA  . ALA B 1 140 ? -16.063 -32.324 11.756 1.00 62.78  ? 172 ALA B CA  1 ? 
ATOM   3436 C C   . ALA B 1 140 ? -16.311 -33.570 12.601 1.00 58.76  ? 172 ALA B C   1 ? 
ATOM   3437 O O   . ALA B 1 140 ? -16.523 -34.667 12.093 1.00 62.85  ? 172 ALA B O   1 ? 
ATOM   3438 C CB  . ALA B 1 140 ? -14.621 -31.886 11.857 1.00 63.93  ? 172 ALA B CB  1 ? 
ATOM   3439 N N   . VAL B 1 141 ? -16.259 -33.405 13.914 1.00 54.12  ? 173 VAL B N   1 ? 
ATOM   3440 C CA  . VAL B 1 141 ? -16.346 -34.560 14.781 1.00 57.57  ? 173 VAL B CA  1 ? 
ATOM   3441 C C   . VAL B 1 141 ? -17.651 -35.295 14.499 1.00 66.02  ? 173 VAL B C   1 ? 
ATOM   3442 O O   . VAL B 1 141 ? -17.634 -36.506 14.313 1.00 73.14  ? 173 VAL B O   1 ? 
ATOM   3443 C CB  . VAL B 1 141 ? -16.233 -34.117 16.248 1.00 57.13  ? 173 VAL B CB  1 ? 
ATOM   3444 C CG1 . VAL B 1 141 ? -16.630 -35.224 17.213 1.00 60.83  ? 173 VAL B CG1 1 ? 
ATOM   3445 C CG2 . VAL B 1 141 ? -14.827 -33.618 16.545 1.00 57.60  ? 173 VAL B CG2 1 ? 
ATOM   3446 N N   . ILE B 1 142 ? -18.764 -34.543 14.480 1.00 76.44  ? 174 ILE B N   1 ? 
ATOM   3447 C CA  . ILE B 1 142 ? -20.105 -35.074 14.273 1.00 72.14  ? 174 ILE B CA  1 ? 
ATOM   3448 C C   . ILE B 1 142 ? -20.164 -35.792 12.924 1.00 69.37  ? 174 ILE B C   1 ? 
ATOM   3449 O O   . ILE B 1 142 ? -20.498 -36.970 12.863 1.00 72.13  ? 174 ILE B O   1 ? 
ATOM   3450 C CB  . ILE B 1 142 ? -21.173 -33.964 14.367 1.00 79.56  ? 174 ILE B CB  1 ? 
ATOM   3451 C CG1 . ILE B 1 142 ? -21.334 -33.442 15.792 1.00 78.76  ? 174 ILE B CG1 1 ? 
ATOM   3452 C CG2 . ILE B 1 142 ? -22.518 -34.448 13.818 1.00 80.96  ? 174 ILE B CG2 1 ? 
ATOM   3453 C CD1 . ILE B 1 142 ? -22.180 -32.181 15.889 1.00 82.48  ? 174 ILE B CD1 1 ? 
ATOM   3454 N N   . LYS B 1 143 ? -19.835 -35.081 11.842 1.00 65.00  ? 175 LYS B N   1 ? 
ATOM   3455 C CA  . LYS B 1 143 ? -19.809 -35.698 10.528 1.00 65.92  ? 175 LYS B CA  1 ? 
ATOM   3456 C C   . LYS B 1 143 ? -18.937 -36.953 10.558 1.00 80.19  ? 175 LYS B C   1 ? 
ATOM   3457 O O   . LYS B 1 143 ? -19.255 -37.952 9.909  1.00 88.52  ? 175 LYS B O   1 ? 
ATOM   3458 C CB  . LYS B 1 143 ? -19.328 -34.691 9.486  1.00 70.67  ? 175 LYS B CB  1 ? 
ATOM   3459 C CG  . LYS B 1 143 ? -20.347 -33.600 9.188  1.00 79.51  ? 175 LYS B CG  1 ? 
ATOM   3460 C CD  . LYS B 1 143 ? -19.978 -32.718 7.999  1.00 83.82  ? 175 LYS B CD  1 ? 
ATOM   3461 C CE  . LYS B 1 143 ? -21.145 -31.942 7.476  1.00 84.66  ? 175 LYS B CE  1 ? 
ATOM   3462 N NZ  . LYS B 1 143 ? -20.706 -30.894 6.551  1.00 90.82  ? 175 LYS B NZ  1 ? 
ATOM   3463 N N   . GLY B 1 144 ? -17.843 -36.881 11.327 1.00 84.41  ? 176 GLY B N   1 ? 
ATOM   3464 C CA  . GLY B 1 144 ? -16.936 -37.998 11.524 1.00 77.82  ? 176 GLY B CA  1 ? 
ATOM   3465 C C   . GLY B 1 144 ? -17.652 -39.209 12.111 1.00 73.61  ? 176 GLY B C   1 ? 
ATOM   3466 O O   . GLY B 1 144 ? -17.635 -40.277 11.517 1.00 88.08  ? 176 GLY B O   1 ? 
ATOM   3467 N N   . LEU B 1 145 ? -18.280 -39.044 13.275 1.00 76.65  ? 177 LEU B N   1 ? 
ATOM   3468 C CA  . LEU B 1 145 ? -19.005 -40.134 13.910 1.00 87.38  ? 177 LEU B CA  1 ? 
ATOM   3469 C C   . LEU B 1 145 ? -20.187 -40.586 13.046 1.00 93.61  ? 177 LEU B C   1 ? 
ATOM   3470 O O   . LEU B 1 145 ? -20.659 -41.718 13.147 1.00 85.67  ? 177 LEU B O   1 ? 
ATOM   3471 C CB  . LEU B 1 145 ? -19.463 -39.652 15.284 1.00 84.48  ? 177 LEU B CB  1 ? 
ATOM   3472 C CG  . LEU B 1 145 ? -18.336 -39.229 16.228 1.00 84.38  ? 177 LEU B CG  1 ? 
ATOM   3473 C CD1 . LEU B 1 145 ? -18.880 -38.643 17.512 1.00 80.32  ? 177 LEU B CD1 1 ? 
ATOM   3474 C CD2 . LEU B 1 145 ? -17.412 -40.402 16.511 1.00 89.70  ? 177 LEU B CD2 1 ? 
ATOM   3475 N N   . THR B 1 146 ? -20.664 -39.690 12.185 1.00 91.60  ? 178 THR B N   1 ? 
ATOM   3476 C CA  . THR B 1 146 ? -21.835 -39.968 11.378 1.00 90.50  ? 178 THR B CA  1 ? 
ATOM   3477 C C   . THR B 1 146 ? -21.442 -40.897 10.232 1.00 95.81  ? 178 THR B C   1 ? 
ATOM   3478 O O   . THR B 1 146 ? -22.296 -41.604 9.706  1.00 111.17 ? 178 THR B O   1 ? 
ATOM   3479 C CB  . THR B 1 146 ? -22.439 -38.632 10.939 1.00 83.14  ? 178 THR B CB  1 ? 
ATOM   3480 O OG1 . THR B 1 146 ? -23.312 -38.290 12.016 1.00 78.15  ? 178 THR B OG1 1 ? 
ATOM   3481 C CG2 . THR B 1 146 ? -23.212 -38.697 9.636  1.00 79.38  ? 178 THR B CG2 1 ? 
ATOM   3482 N N   . TYR B 1 147 ? -20.153 -40.925 9.872  1.00 94.28  ? 179 TYR B N   1 ? 
ATOM   3483 C CA  . TYR B 1 147 ? -19.670 -41.805 8.813  1.00 100.41 ? 179 TYR B CA  1 ? 
ATOM   3484 C C   . TYR B 1 147 ? -19.318 -43.185 9.376  1.00 103.54 ? 179 TYR B C   1 ? 
ATOM   3485 O O   . TYR B 1 147 ? -19.481 -44.197 8.693  1.00 111.12 ? 179 TYR B O   1 ? 
ATOM   3486 C CB  . TYR B 1 147 ? -18.490 -41.113 8.132  1.00 94.29  ? 179 TYR B CB  1 ? 
ATOM   3487 C CG  . TYR B 1 147 ? -17.779 -41.917 7.056  1.00 100.36 ? 179 TYR B CG  1 ? 
ATOM   3488 C CD1 . TYR B 1 147 ? -16.949 -42.984 7.387  1.00 103.43 ? 179 TYR B CD1 1 ? 
ATOM   3489 C CD2 . TYR B 1 147 ? -17.876 -41.559 5.714  1.00 104.97 ? 179 TYR B CD2 1 ? 
ATOM   3490 C CE1 . TYR B 1 147 ? -16.267 -43.695 6.412  1.00 105.41 ? 179 TYR B CE1 1 ? 
ATOM   3491 C CE2 . TYR B 1 147 ? -17.197 -42.260 4.729  1.00 103.53 ? 179 TYR B CE2 1 ? 
ATOM   3492 C CZ  . TYR B 1 147 ? -16.388 -43.328 5.082  1.00 107.51 ? 179 TYR B CZ  1 ? 
ATOM   3493 O OH  . TYR B 1 147 ? -15.717 -44.028 4.121  1.00 106.03 ? 179 TYR B OH  1 ? 
ATOM   3494 N N   . LEU B 1 148 ? -18.852 -43.221 10.631 1.00 89.20  ? 180 LEU B N   1 ? 
ATOM   3495 C CA  . LEU B 1 148 ? -18.522 -44.466 11.305 1.00 93.43  ? 180 LEU B CA  1 ? 
ATOM   3496 C C   . LEU B 1 148 ? -19.761 -45.322 11.584 1.00 103.99 ? 180 LEU B C   1 ? 
ATOM   3497 O O   . LEU B 1 148 ? -19.614 -46.507 11.888 1.00 113.15 ? 180 LEU B O   1 ? 
ATOM   3498 C CB  . LEU B 1 148 ? -17.769 -44.165 12.600 1.00 90.18  ? 180 LEU B CB  1 ? 
ATOM   3499 C CG  . LEU B 1 148 ? -16.376 -43.537 12.462 1.00 94.47  ? 180 LEU B CG  1 ? 
ATOM   3500 C CD1 . LEU B 1 148 ? -15.687 -43.571 13.820 1.00 92.16  ? 180 LEU B CD1 1 ? 
ATOM   3501 C CD2 . LEU B 1 148 ? -15.498 -44.195 11.398 1.00 95.31  ? 180 LEU B CD2 1 ? 
ATOM   3502 N N   . ARG B 1 149 ? -20.964 -44.730 11.526 1.00 109.22 ? 181 ARG B N   1 ? 
ATOM   3503 C CA  . ARG B 1 149 ? -22.194 -45.481 11.725 1.00 109.87 ? 181 ARG B CA  1 ? 
ATOM   3504 C C   . ARG B 1 149 ? -22.744 -45.909 10.369 1.00 110.95 ? 181 ARG B C   1 ? 
ATOM   3505 O O   . ARG B 1 149 ? -22.944 -47.102 10.147 1.00 110.69 ? 181 ARG B O   1 ? 
ATOM   3506 C CB  . ARG B 1 149 ? -23.293 -44.739 12.494 1.00 116.29 ? 181 ARG B CB  1 ? 
ATOM   3507 C CG  . ARG B 1 149 ? -23.028 -44.534 13.980 1.00 126.79 ? 181 ARG B CG  1 ? 
ATOM   3508 C CD  . ARG B 1 149 ? -24.200 -44.935 14.891 1.00 138.65 ? 181 ARG B CD  1 ? 
ATOM   3509 N NE  . ARG B 1 149 ? -25.563 -44.735 14.376 1.00 142.97 ? 181 ARG B NE  1 ? 
ATOM   3510 C CZ  . ARG B 1 149 ? -26.313 -43.628 14.397 1.00 143.26 ? 181 ARG B CZ  1 ? 
ATOM   3511 N NH1 . ARG B 1 149 ? -27.557 -43.672 13.945 1.00 137.11 ? 181 ARG B NH1 1 ? 
ATOM   3512 N NH2 . ARG B 1 149 ? -25.848 -42.492 14.890 1.00 149.12 ? 181 ARG B NH2 1 ? 
ATOM   3513 N N   . GLU B 1 150 ? -22.992 -44.931 9.484  1.00 104.76 ? 182 GLU B N   1 ? 
ATOM   3514 C CA  . GLU B 1 150 ? -23.510 -45.208 8.152  1.00 115.06 ? 182 GLU B CA  1 ? 
ATOM   3515 C C   . GLU B 1 150 ? -22.553 -46.156 7.433  1.00 129.23 ? 182 GLU B C   1 ? 
ATOM   3516 O O   . GLU B 1 150 ? -22.766 -47.367 7.462  1.00 133.85 ? 182 GLU B O   1 ? 
ATOM   3517 C CB  . GLU B 1 150 ? -23.795 -43.938 7.345  1.00 126.54 ? 182 GLU B CB  1 ? 
ATOM   3518 C CG  . GLU B 1 150 ? -24.106 -44.165 5.862  1.00 133.62 ? 182 GLU B CG  1 ? 
ATOM   3519 C CD  . GLU B 1 150 ? -25.243 -45.117 5.507  1.00 132.67 ? 182 GLU B CD  1 ? 
ATOM   3520 O OE1 . GLU B 1 150 ? -26.256 -44.644 4.943  1.00 122.05 ? 182 GLU B OE1 1 ? 
ATOM   3521 O OE2 . GLU B 1 150 ? -25.117 -46.334 5.760  1.00 128.91 ? 182 GLU B OE2 1 ? 
ATOM   3522 N N   . LYS B 1 151 ? -21.504 -45.609 6.800  1.00 142.21 ? 183 LYS B N   1 ? 
ATOM   3523 C CA  . LYS B 1 151 ? -20.646 -46.408 5.937  1.00 138.28 ? 183 LYS B CA  1 ? 
ATOM   3524 C C   . LYS B 1 151 ? -20.117 -47.563 6.780  1.00 130.73 ? 183 LYS B C   1 ? 
ATOM   3525 O O   . LYS B 1 151 ? -19.246 -47.364 7.624  1.00 120.33 ? 183 LYS B O   1 ? 
ATOM   3526 C CB  . LYS B 1 151 ? -19.514 -45.602 5.284  1.00 133.52 ? 183 LYS B CB  1 ? 
ATOM   3527 C CG  . LYS B 1 151 ? -19.333 -45.840 3.781  1.00 140.06 ? 183 LYS B CG  1 ? 
ATOM   3528 C CD  . LYS B 1 151 ? -18.629 -47.119 3.337  1.00 146.41 ? 183 LYS B CD  1 ? 
ATOM   3529 C CE  . LYS B 1 151 ? -17.148 -46.984 3.124  1.00 145.57 ? 183 LYS B CE  1 ? 
ATOM   3530 N NZ  . LYS B 1 151 ? -16.389 -46.948 4.376  1.00 143.23 ? 183 LYS B NZ  1 ? 
ATOM   3531 N N   . HIS B 1 152 ? -20.715 -48.745 6.575  1.00 145.97 ? 184 HIS B N   1 ? 
ATOM   3532 C CA  . HIS B 1 152 ? -20.453 -49.926 7.382  1.00 145.26 ? 184 HIS B CA  1 ? 
ATOM   3533 C C   . HIS B 1 152 ? -20.644 -49.520 8.843  1.00 124.33 ? 184 HIS B C   1 ? 
ATOM   3534 O O   . HIS B 1 152 ? -20.636 -48.333 9.155  1.00 101.38 ? 184 HIS B O   1 ? 
ATOM   3535 C CB  . HIS B 1 152 ? -19.096 -50.537 7.001  1.00 160.05 ? 184 HIS B CB  1 ? 
ATOM   3536 C CG  . HIS B 1 152 ? -18.905 -50.788 5.529  1.00 179.32 ? 184 HIS B CG  1 ? 
ATOM   3537 N ND1 . HIS B 1 152 ? -19.663 -50.198 4.538  1.00 190.39 ? 184 HIS B ND1 1 ? 
ATOM   3538 C CD2 . HIS B 1 152 ? -18.026 -51.575 4.884  1.00 186.26 ? 184 HIS B CD2 1 ? 
ATOM   3539 C CE1 . HIS B 1 152 ? -19.247 -50.613 3.348  1.00 185.16 ? 184 HIS B CE1 1 ? 
ATOM   3540 N NE2 . HIS B 1 152 ? -18.252 -51.450 3.535  1.00 184.14 ? 184 HIS B NE2 1 ? 
ATOM   3541 N N   . LYS B 1 153 ? -20.846 -50.496 9.733  1.00 121.12 ? 185 LYS B N   1 ? 
ATOM   3542 C CA  . LYS B 1 153 ? -21.172 -50.196 11.119 1.00 130.49 ? 185 LYS B CA  1 ? 
ATOM   3543 C C   . LYS B 1 153 ? -19.886 -50.087 11.934 1.00 133.10 ? 185 LYS B C   1 ? 
ATOM   3544 O O   . LYS B 1 153 ? -19.886 -50.414 13.117 1.00 134.89 ? 185 LYS B O   1 ? 
ATOM   3545 C CB  . LYS B 1 153 ? -22.060 -51.269 11.770 1.00 134.57 ? 185 LYS B CB  1 ? 
ATOM   3546 C CG  . LYS B 1 153 ? -23.195 -51.844 10.935 1.00 127.61 ? 185 LYS B CG  1 ? 
ATOM   3547 C CD  . LYS B 1 153 ? -24.121 -50.805 10.321 1.00 123.74 ? 185 LYS B CD  1 ? 
ATOM   3548 C CE  . LYS B 1 153 ? -24.962 -51.398 9.244  1.00 123.64 ? 185 LYS B CE  1 ? 
ATOM   3549 N NZ  . LYS B 1 153 ? -25.474 -50.345 8.368  1.00 123.52 ? 185 LYS B NZ  1 ? 
ATOM   3550 N N   . ILE B 1 154 ? -18.805 -49.599 11.308 1.00 144.95 ? 186 ILE B N   1 ? 
ATOM   3551 C CA  . ILE B 1 154 ? -17.458 -49.822 11.818 1.00 144.64 ? 186 ILE B CA  1 ? 
ATOM   3552 C C   . ILE B 1 154 ? -17.282 -49.145 13.177 1.00 145.08 ? 186 ILE B C   1 ? 
ATOM   3553 O O   . ILE B 1 154 ? -16.861 -49.803 14.120 1.00 153.07 ? 186 ILE B O   1 ? 
ATOM   3554 C CB  . ILE B 1 154 ? -16.363 -49.435 10.801 1.00 135.57 ? 186 ILE B CB  1 ? 
ATOM   3555 C CG1 . ILE B 1 154 ? -16.545 -48.023 10.233 1.00 125.40 ? 186 ILE B CG1 1 ? 
ATOM   3556 C CG2 . ILE B 1 154 ? -16.276 -50.490 9.695  1.00 139.77 ? 186 ILE B CG2 1 ? 
ATOM   3557 C CD1 . ILE B 1 154 ? -15.584 -47.677 9.110  1.00 123.80 ? 186 ILE B CD1 1 ? 
ATOM   3558 N N   . MET B 1 155 ? -17.616 -47.856 13.296 1.00 141.40 ? 187 MET B N   1 ? 
ATOM   3559 C CA  . MET B 1 155 ? -17.682 -47.208 14.602 1.00 159.13 ? 187 MET B CA  1 ? 
ATOM   3560 C C   . MET B 1 155 ? -16.391 -47.437 15.408 1.00 152.12 ? 187 MET B C   1 ? 
ATOM   3561 O O   . MET B 1 155 ? -15.301 -47.313 14.855 1.00 136.61 ? 187 MET B O   1 ? 
ATOM   3562 C CB  . MET B 1 155 ? -18.968 -47.646 15.321 1.00 171.28 ? 187 MET B CB  1 ? 
ATOM   3563 C CG  . MET B 1 155 ? -19.986 -46.537 15.501 1.00 182.05 ? 187 MET B CG  1 ? 
ATOM   3564 S SD  . MET B 1 155 ? -19.349 -45.262 16.607 1.00 199.94 ? 187 MET B SD  1 ? 
ATOM   3565 C CE  . MET B 1 155 ? -20.790 -44.874 17.605 1.00 190.91 ? 187 MET B CE  1 ? 
ATOM   3566 N N   . HIS B 1 156 ? -16.527 -47.731 16.716 1.00 158.89 ? 188 HIS B N   1 ? 
ATOM   3567 C CA  . HIS B 1 156 ? -15.454 -47.786 17.714 1.00 168.78 ? 188 HIS B CA  1 ? 
ATOM   3568 C C   . HIS B 1 156 ? -14.537 -46.556 17.707 1.00 162.16 ? 188 HIS B C   1 ? 
ATOM   3569 O O   . HIS B 1 156 ? -14.589 -45.725 16.803 1.00 169.15 ? 188 HIS B O   1 ? 
ATOM   3570 C CB  . HIS B 1 156 ? -14.738 -49.151 17.747 1.00 172.48 ? 188 HIS B CB  1 ? 
ATOM   3571 C CG  . HIS B 1 156 ? -14.467 -49.845 16.452 1.00 176.63 ? 188 HIS B CG  1 ? 
ATOM   3572 N ND1 . HIS B 1 156 ? -13.242 -49.854 15.813 1.00 177.32 ? 188 HIS B ND1 1 ? 
ATOM   3573 C CD2 . HIS B 1 156 ? -15.266 -50.634 15.729 1.00 179.37 ? 188 HIS B CD2 1 ? 
ATOM   3574 C CE1 . HIS B 1 156 ? -13.328 -50.591 14.714 1.00 174.62 ? 188 HIS B CE1 1 ? 
ATOM   3575 N NE2 . HIS B 1 156 ? -14.550 -51.071 14.642 1.00 183.12 ? 188 HIS B NE2 1 ? 
ATOM   3576 N N   . ARG B 1 157 ? -13.734 -46.445 18.782 1.00 151.22 ? 189 ARG B N   1 ? 
ATOM   3577 C CA  . ARG B 1 157 ? -12.778 -45.366 19.024 1.00 147.47 ? 189 ARG B CA  1 ? 
ATOM   3578 C C   . ARG B 1 157 ? -13.417 -44.305 19.931 1.00 141.34 ? 189 ARG B C   1 ? 
ATOM   3579 O O   . ARG B 1 157 ? -14.631 -44.089 19.869 1.00 104.65 ? 189 ARG B O   1 ? 
ATOM   3580 C CB  . ARG B 1 157 ? -12.200 -44.780 17.729 1.00 139.79 ? 189 ARG B CB  1 ? 
ATOM   3581 C CG  . ARG B 1 157 ? -10.910 -43.992 17.905 1.00 126.89 ? 189 ARG B CG  1 ? 
ATOM   3582 C CD  . ARG B 1 157 ? -9.700  -44.875 18.137 1.00 120.33 ? 189 ARG B CD  1 ? 
ATOM   3583 N NE  . ARG B 1 157 ? -8.473  -44.098 18.363 1.00 124.89 ? 189 ARG B NE  1 ? 
ATOM   3584 C CZ  . ARG B 1 157 ? -7.249  -44.605 18.569 1.00 129.19 ? 189 ARG B CZ  1 ? 
ATOM   3585 N NH1 . ARG B 1 157 ? -7.049  -45.915 18.542 1.00 131.39 ? 189 ARG B NH1 1 ? 
ATOM   3586 N NH2 . ARG B 1 157 ? -6.218  -43.803 18.800 1.00 115.57 ? 189 ARG B NH2 1 ? 
ATOM   3587 N N   . ASP B 1 158 ? -12.574 -43.657 20.765 1.00 140.00 ? 190 ASP B N   1 ? 
ATOM   3588 C CA  . ASP B 1 158 ? -12.991 -42.687 21.778 1.00 138.30 ? 190 ASP B CA  1 ? 
ATOM   3589 C C   . ASP B 1 158 ? -12.566 -41.270 21.372 1.00 121.51 ? 190 ASP B C   1 ? 
ATOM   3590 O O   . ASP B 1 158 ? -11.501 -41.083 20.782 1.00 114.16 ? 190 ASP B O   1 ? 
ATOM   3591 C CB  . ASP B 1 158 ? -12.453 -43.074 23.150 1.00 134.31 ? 190 ASP B CB  1 ? 
ATOM   3592 C CG  . ASP B 1 158 ? -13.124 -42.408 24.346 1.00 130.80 ? 190 ASP B CG  1 ? 
ATOM   3593 O OD1 . ASP B 1 158 ? -13.652 -41.286 24.184 1.00 110.78 ? 190 ASP B OD1 1 ? 
ATOM   3594 O OD2 . ASP B 1 158 ? -13.147 -43.038 25.425 1.00 128.03 ? 190 ASP B OD2 1 ? 
ATOM   3595 N N   . VAL B 1 159 ? -13.397 -40.270 21.716 1.00 97.83  ? 191 VAL B N   1 ? 
ATOM   3596 C CA  . VAL B 1 159 ? -13.236 -38.921 21.188 1.00 90.10  ? 191 VAL B CA  1 ? 
ATOM   3597 C C   . VAL B 1 159 ? -12.691 -37.995 22.273 1.00 82.16  ? 191 VAL B C   1 ? 
ATOM   3598 O O   . VAL B 1 159 ? -13.315 -37.800 23.314 1.00 78.37  ? 191 VAL B O   1 ? 
ATOM   3599 C CB  . VAL B 1 159 ? -14.527 -38.335 20.589 1.00 84.21  ? 191 VAL B CB  1 ? 
ATOM   3600 C CG1 . VAL B 1 159 ? -14.402 -36.835 20.346 1.00 81.13  ? 191 VAL B CG1 1 ? 
ATOM   3601 C CG2 . VAL B 1 159 ? -14.919 -39.044 19.300 1.00 83.98  ? 191 VAL B CG2 1 ? 
ATOM   3602 N N   . LYS B 1 160 ? -11.538 -37.386 21.978 1.00 66.92  ? 192 LYS B N   1 ? 
ATOM   3603 C CA  . LYS B 1 160 ? -10.882 -36.483 22.902 1.00 61.95  ? 192 LYS B CA  1 ? 
ATOM   3604 C C   . LYS B 1 160 ? -9.934  -35.593 22.101 1.00 58.04  ? 192 LYS B C   1 ? 
ATOM   3605 O O   . LYS B 1 160 ? -9.665  -35.874 20.932 1.00 64.04  ? 192 LYS B O   1 ? 
ATOM   3606 C CB  . LYS B 1 160 ? -10.250 -37.324 24.020 1.00 71.89  ? 192 LYS B CB  1 ? 
ATOM   3607 C CG  . LYS B 1 160 ? -9.065  -38.213 23.645 1.00 85.91  ? 192 LYS B CG  1 ? 
ATOM   3608 C CD  . LYS B 1 160 ? -8.766  -39.365 24.610 1.00 99.28  ? 192 LYS B CD  1 ? 
ATOM   3609 C CE  . LYS B 1 160 ? -9.932  -40.318 24.760 1.00 110.35 ? 192 LYS B CE  1 ? 
ATOM   3610 N NZ  . LYS B 1 160 ? -9.590  -41.707 25.087 1.00 107.53 ? 192 LYS B NZ  1 ? 
ATOM   3611 N N   . PRO B 1 161 ? -9.400  -34.495 22.687 1.00 54.52  ? 193 PRO B N   1 ? 
ATOM   3612 C CA  . PRO B 1 161 ? -8.466  -33.617 21.975 1.00 52.56  ? 193 PRO B CA  1 ? 
ATOM   3613 C C   . PRO B 1 161 ? -7.296  -34.332 21.292 1.00 57.33  ? 193 PRO B C   1 ? 
ATOM   3614 O O   . PRO B 1 161 ? -6.917  -33.977 20.170 1.00 56.75  ? 193 PRO B O   1 ? 
ATOM   3615 C CB  . PRO B 1 161 ? -8.011  -32.675 23.098 1.00 55.65  ? 193 PRO B CB  1 ? 
ATOM   3616 C CG  . PRO B 1 161 ? -9.209  -32.605 24.024 1.00 55.33  ? 193 PRO B CG  1 ? 
ATOM   3617 C CD  . PRO B 1 161 ? -9.670  -34.042 24.062 1.00 55.15  ? 193 PRO B CD  1 ? 
ATOM   3618 N N   . SER B 1 162 ? -6.760  -35.377 21.937 1.00 59.63  ? 194 SER B N   1 ? 
ATOM   3619 C CA  . SER B 1 162 ? -5.654  -36.146 21.368 1.00 67.28  ? 194 SER B CA  1 ? 
ATOM   3620 C C   . SER B 1 162 ? -6.052  -36.915 20.106 1.00 71.21  ? 194 SER B C   1 ? 
ATOM   3621 O O   . SER B 1 162 ? -5.182  -37.206 19.287 1.00 67.99  ? 194 SER B O   1 ? 
ATOM   3622 C CB  . SER B 1 162 ? -5.030  -37.104 22.365 1.00 58.69  ? 194 SER B CB  1 ? 
ATOM   3623 O OG  . SER B 1 162 ? -5.957  -37.532 23.353 1.00 71.20  ? 194 SER B OG  1 ? 
ATOM   3624 N N   . ASN B 1 163 ? -7.340  -37.255 19.948 1.00 68.81  ? 195 ASN B N   1 ? 
ATOM   3625 C CA  . ASN B 1 163 ? -7.767  -38.067 18.815 1.00 74.22  ? 195 ASN B CA  1 ? 
ATOM   3626 C C   . ASN B 1 163 ? -8.273  -37.191 17.669 1.00 70.02  ? 195 ASN B C   1 ? 
ATOM   3627 O O   . ASN B 1 163 ? -8.665  -37.713 16.624 1.00 71.90  ? 195 ASN B O   1 ? 
ATOM   3628 C CB  . ASN B 1 163 ? -8.813  -39.095 19.232 1.00 88.33  ? 195 ASN B CB  1 ? 
ATOM   3629 C CG  . ASN B 1 163 ? -8.250  -40.130 20.176 1.00 95.97  ? 195 ASN B CG  1 ? 
ATOM   3630 O OD1 . ASN B 1 163 ? -7.069  -40.496 20.079 1.00 98.66  ? 195 ASN B OD1 1 ? 
ATOM   3631 N ND2 . ASN B 1 163 ? -9.077  -40.595 21.101 1.00 93.71  ? 195 ASN B ND2 1 ? 
ATOM   3632 N N   . ILE B 1 164 ? -8.269  -35.865 17.857 1.00 68.01  ? 196 ILE B N   1 ? 
ATOM   3633 C CA  . ILE B 1 164 ? -8.670  -34.943 16.801 1.00 61.93  ? 196 ILE B CA  1 ? 
ATOM   3634 C C   . ILE B 1 164 ? -7.417  -34.277 16.244 1.00 60.25  ? 196 ILE B C   1 ? 
ATOM   3635 O O   . ILE B 1 164 ? -6.690  -33.626 16.990 1.00 55.27  ? 196 ILE B O   1 ? 
ATOM   3636 C CB  . ILE B 1 164 ? -9.689  -33.899 17.303 1.00 66.40  ? 196 ILE B CB  1 ? 
ATOM   3637 C CG1 . ILE B 1 164 ? -10.765 -34.539 18.202 1.00 62.07  ? 196 ILE B CG1 1 ? 
ATOM   3638 C CG2 . ILE B 1 164 ? -10.323 -33.147 16.129 1.00 63.90  ? 196 ILE B CG2 1 ? 
ATOM   3639 C CD1 . ILE B 1 164 ? -11.508 -33.551 19.072 1.00 56.48  ? 196 ILE B CD1 1 ? 
ATOM   3640 N N   . LEU B 1 165 ? -7.193  -34.446 14.935 1.00 55.74  ? 197 LEU B N   1 ? 
ATOM   3641 C CA  . LEU B 1 165 ? -5.998  -33.971 14.273 1.00 56.59  ? 197 LEU B CA  1 ? 
ATOM   3642 C C   . LEU B 1 165 ? -6.411  -32.917 13.259 1.00 60.09  ? 197 LEU B C   1 ? 
ATOM   3643 O O   . LEU B 1 165 ? -7.523  -32.964 12.744 1.00 59.86  ? 197 LEU B O   1 ? 
ATOM   3644 C CB  . LEU B 1 165 ? -5.244  -35.096 13.562 1.00 62.38  ? 197 LEU B CB  1 ? 
ATOM   3645 C CG  . LEU B 1 165 ? -5.045  -36.411 14.319 1.00 65.95  ? 197 LEU B CG  1 ? 
ATOM   3646 C CD1 . LEU B 1 165 ? -4.005  -37.236 13.545 1.00 65.95  ? 197 LEU B CD1 1 ? 
ATOM   3647 C CD2 . LEU B 1 165 ? -4.638  -36.231 15.778 1.00 64.94  ? 197 LEU B CD2 1 ? 
ATOM   3648 N N   . VAL B 1 166 ? -5.467  -32.029 12.927 1.00 60.44  ? 198 VAL B N   1 ? 
ATOM   3649 C CA  . VAL B 1 166 ? -5.749  -30.880 12.093 1.00 61.61  ? 198 VAL B CA  1 ? 
ATOM   3650 C C   . VAL B 1 166 ? -4.574  -30.640 11.147 1.00 61.01  ? 198 VAL B C   1 ? 
ATOM   3651 O O   . VAL B 1 166 ? -3.503  -31.214 11.335 1.00 57.65  ? 198 VAL B O   1 ? 
ATOM   3652 C CB  . VAL B 1 166 ? -6.031  -29.677 13.015 1.00 58.97  ? 198 VAL B CB  1 ? 
ATOM   3653 C CG1 . VAL B 1 166 ? -7.359  -29.843 13.736 1.00 53.48  ? 198 VAL B CG1 1 ? 
ATOM   3654 C CG2 . VAL B 1 166 ? -4.914  -29.428 14.029 1.00 57.69  ? 198 VAL B CG2 1 ? 
ATOM   3655 N N   . ASN B 1 167 ? -4.777  -29.793 10.132 1.00 62.13  ? 199 ASN B N   1 ? 
ATOM   3656 C CA  . ASN B 1 167 ? -3.703  -29.505 9.193  1.00 71.08  ? 199 ASN B CA  1 ? 
ATOM   3657 C C   . ASN B 1 167 ? -3.871  -28.109 8.578  1.00 69.42  ? 199 ASN B C   1 ? 
ATOM   3658 O O   . ASN B 1 167 ? -4.921  -27.480 8.689  1.00 65.76  ? 199 ASN B O   1 ? 
ATOM   3659 C CB  . ASN B 1 167 ? -3.547  -30.653 8.195  1.00 70.74  ? 199 ASN B CB  1 ? 
ATOM   3660 C CG  . ASN B 1 167 ? -4.607  -30.670 7.118  1.00 77.29  ? 199 ASN B CG  1 ? 
ATOM   3661 O OD1 . ASN B 1 167 ? -5.137  -29.621 6.728  1.00 78.50  ? 199 ASN B OD1 1 ? 
ATOM   3662 N ND2 . ASN B 1 167 ? -4.894  -31.851 6.590  1.00 73.13  ? 199 ASN B ND2 1 ? 
ATOM   3663 N N   . SER B 1 168 ? -2.802  -27.641 7.918  1.00 66.64  ? 200 SER B N   1 ? 
ATOM   3664 C CA  . SER B 1 168 ? -2.730  -26.298 7.370  1.00 73.85  ? 200 SER B CA  1 ? 
ATOM   3665 C C   . SER B 1 168 ? -3.677  -26.094 6.182  1.00 74.24  ? 200 SER B C   1 ? 
ATOM   3666 O O   . SER B 1 168 ? -3.719  -24.999 5.621  1.00 77.45  ? 200 SER B O   1 ? 
ATOM   3667 C CB  . SER B 1 168 ? -1.310  -25.968 6.993  1.00 78.63  ? 200 SER B CB  1 ? 
ATOM   3668 O OG  . SER B 1 168 ? -0.782  -26.921 6.079  1.00 81.58  ? 200 SER B OG  1 ? 
ATOM   3669 N N   . ARG B 1 169 ? -4.449  -27.124 5.805  1.00 74.57  ? 201 ARG B N   1 ? 
ATOM   3670 C CA  . ARG B 1 169 ? -5.504  -26.975 4.808  1.00 82.45  ? 201 ARG B CA  1 ? 
ATOM   3671 C C   . ARG B 1 169 ? -6.868  -26.887 5.496  1.00 83.43  ? 201 ARG B C   1 ? 
ATOM   3672 O O   . ARG B 1 169 ? -7.913  -26.939 4.846  1.00 80.29  ? 201 ARG B O   1 ? 
ATOM   3673 C CB  . ARG B 1 169 ? -5.437  -28.115 3.784  1.00 83.81  ? 201 ARG B CB  1 ? 
ATOM   3674 C CG  . ARG B 1 169 ? -4.344  -27.940 2.735  1.00 94.00  ? 201 ARG B CG  1 ? 
ATOM   3675 C CD  . ARG B 1 169 ? -3.978  -29.226 2.001  1.00 99.61  ? 201 ARG B CD  1 ? 
ATOM   3676 N NE  . ARG B 1 169 ? -5.134  -30.094 1.737  1.00 107.64 ? 201 ARG B NE  1 ? 
ATOM   3677 C CZ  . ARG B 1 169 ? -5.075  -31.396 1.446  1.00 109.12 ? 201 ARG B CZ  1 ? 
ATOM   3678 N NH1 . ARG B 1 169 ? -6.177  -32.128 1.466  1.00 105.99 ? 201 ARG B NH1 1 ? 
ATOM   3679 N NH2 . ARG B 1 169 ? -3.914  -31.979 1.198  1.00 108.58 ? 201 ARG B NH2 1 ? 
ATOM   3680 N N   . GLY B 1 170 ? -6.849  -26.741 6.823  1.00 76.63  ? 202 GLY B N   1 ? 
ATOM   3681 C CA  . GLY B 1 170 ? -8.062  -26.566 7.595  1.00 69.99  ? 202 GLY B CA  1 ? 
ATOM   3682 C C   . GLY B 1 170 ? -8.923  -27.824 7.631  1.00 73.16  ? 202 GLY B C   1 ? 
ATOM   3683 O O   . GLY B 1 170 ? -10.136 -27.727 7.779  1.00 78.53  ? 202 GLY B O   1 ? 
ATOM   3684 N N   . GLU B 1 171 ? -8.294  -28.998 7.535  1.00 74.33  ? 203 GLU B N   1 ? 
ATOM   3685 C CA  . GLU B 1 171 ? -9.018  -30.241 7.722  1.00 72.03  ? 203 GLU B CA  1 ? 
ATOM   3686 C C   . GLU B 1 171 ? -8.937  -30.643 9.188  1.00 64.56  ? 203 GLU B C   1 ? 
ATOM   3687 O O   . GLU B 1 171 ? -7.945  -30.369 9.851  1.00 75.48  ? 203 GLU B O   1 ? 
ATOM   3688 C CB  . GLU B 1 171 ? -8.477  -31.337 6.810  1.00 75.58  ? 203 GLU B CB  1 ? 
ATOM   3689 C CG  . GLU B 1 171 ? -8.528  -30.940 5.339  1.00 79.70  ? 203 GLU B CG  1 ? 
ATOM   3690 C CD  . GLU B 1 171 ? -7.824  -31.915 4.421  1.00 80.37  ? 203 GLU B CD  1 ? 
ATOM   3691 O OE1 . GLU B 1 171 ? -6.594  -31.780 4.236  1.00 81.30  ? 203 GLU B OE1 1 ? 
ATOM   3692 O OE2 . GLU B 1 171 ? -8.505  -32.840 3.935  1.00 91.46  ? 203 GLU B OE2 1 ? 
ATOM   3693 N N   . ILE B 1 172 ? -10.009 -31.276 9.664  1.00 59.71  ? 204 ILE B N   1 ? 
ATOM   3694 C CA  . ILE B 1 172 ? -10.143 -31.765 11.023 1.00 62.63  ? 204 ILE B CA  1 ? 
ATOM   3695 C C   . ILE B 1 172 ? -10.616 -33.211 10.899 1.00 64.95  ? 204 ILE B C   1 ? 
ATOM   3696 O O   . ILE B 1 172 ? -11.583 -33.473 10.192 1.00 68.55  ? 204 ILE B O   1 ? 
ATOM   3697 C CB  . ILE B 1 172 ? -11.158 -30.921 11.818 1.00 60.88  ? 204 ILE B CB  1 ? 
ATOM   3698 C CG1 . ILE B 1 172 ? -10.831 -29.439 11.798 1.00 62.37  ? 204 ILE B CG1 1 ? 
ATOM   3699 C CG2 . ILE B 1 172 ? -11.310 -31.435 13.251 1.00 65.90  ? 204 ILE B CG2 1 ? 
ATOM   3700 C CD1 . ILE B 1 172 ? -12.056 -28.538 11.783 1.00 64.27  ? 204 ILE B CD1 1 ? 
ATOM   3701 N N   . LYS B 1 173 ? -9.929  -34.150 11.558 1.00 64.13  ? 205 LYS B N   1 ? 
ATOM   3702 C CA  . LYS B 1 173 ? -10.212 -35.558 11.350 1.00 58.78  ? 205 LYS B CA  1 ? 
ATOM   3703 C C   . LYS B 1 173 ? -9.975  -36.333 12.633 1.00 57.00  ? 205 LYS B C   1 ? 
ATOM   3704 O O   . LYS B 1 173 ? -9.116  -35.992 13.443 1.00 60.83  ? 205 LYS B O   1 ? 
ATOM   3705 C CB  . LYS B 1 173 ? -9.333  -36.147 10.244 1.00 59.74  ? 205 LYS B CB  1 ? 
ATOM   3706 C CG  . LYS B 1 173 ? -9.210  -35.304 8.971  1.00 58.16  ? 205 LYS B CG  1 ? 
ATOM   3707 C CD  . LYS B 1 173 ? -8.541  -36.058 7.829  1.00 60.79  ? 205 LYS B CD  1 ? 
ATOM   3708 C CE  . LYS B 1 173 ? -8.058  -35.159 6.748  1.00 64.62  ? 205 LYS B CE  1 ? 
ATOM   3709 N NZ  . LYS B 1 173 ? -8.039  -35.853 5.458  1.00 69.53  ? 205 LYS B NZ  1 ? 
ATOM   3710 N N   . LEU B 1 174 ? -10.766 -37.383 12.809 1.00 63.51  ? 206 LEU B N   1 ? 
ATOM   3711 C CA  . LEU B 1 174 ? -10.555 -38.284 13.918 1.00 75.69  ? 206 LEU B CA  1 ? 
ATOM   3712 C C   . LEU B 1 174 ? -9.496  -39.294 13.498 1.00 78.36  ? 206 LEU B C   1 ? 
ATOM   3713 O O   . LEU B 1 174 ? -9.305  -39.572 12.312 1.00 69.70  ? 206 LEU B O   1 ? 
ATOM   3714 C CB  . LEU B 1 174 ? -11.879 -38.935 14.295 1.00 76.52  ? 206 LEU B CB  1 ? 
ATOM   3715 C CG  . LEU B 1 174 ? -12.995 -37.954 14.667 1.00 84.64  ? 206 LEU B CG  1 ? 
ATOM   3716 C CD1 . LEU B 1 174 ? -14.347 -38.627 14.517 1.00 89.80  ? 206 LEU B CD1 1 ? 
ATOM   3717 C CD2 . LEU B 1 174 ? -12.823 -37.405 16.079 1.00 83.66  ? 206 LEU B CD2 1 ? 
ATOM   3718 N N   . CYS B 1 175 ? -8.787  -39.802 14.488 1.00 78.81  ? 207 CYS B N   1 ? 
ATOM   3719 C CA  . CYS B 1 175 ? -7.775  -40.821 14.308 1.00 87.04  ? 207 CYS B CA  1 ? 
ATOM   3720 C C   . CYS B 1 175 ? -8.311  -42.118 14.890 1.00 93.28  ? 207 CYS B C   1 ? 
ATOM   3721 O O   . CYS B 1 175 ? -8.464  -42.214 16.105 1.00 81.79  ? 207 CYS B O   1 ? 
ATOM   3722 C CB  . CYS B 1 175 ? -6.514  -40.403 15.045 1.00 89.53  ? 207 CYS B CB  1 ? 
ATOM   3723 S SG  . CYS B 1 175 ? -5.026  -41.352 14.614 1.00 88.91  ? 207 CYS B SG  1 ? 
ATOM   3724 N N   . ASP B 1 176 ? -8.586  -43.100 14.026 1.00 121.40 ? 208 ASP B N   1 ? 
ATOM   3725 C CA  . ASP B 1 176 ? -9.296  -44.320 14.381 1.00 131.06 ? 208 ASP B CA  1 ? 
ATOM   3726 C C   . ASP B 1 176 ? -8.252  -45.383 14.722 1.00 124.40 ? 208 ASP B C   1 ? 
ATOM   3727 O O   . ASP B 1 176 ? -7.449  -45.172 15.625 1.00 149.81 ? 208 ASP B O   1 ? 
ATOM   3728 C CB  . ASP B 1 176 ? -10.294 -44.659 13.280 1.00 145.14 ? 208 ASP B CB  1 ? 
ATOM   3729 C CG  . ASP B 1 176 ? -11.681 -45.087 13.744 1.00 159.85 ? 208 ASP B CG  1 ? 
ATOM   3730 O OD1 . ASP B 1 176 ? -12.210 -44.451 14.682 1.00 175.46 ? 208 ASP B OD1 1 ? 
ATOM   3731 O OD2 . ASP B 1 176 ? -12.240 -46.027 13.135 1.00 159.55 ? 208 ASP B OD2 1 ? 
ATOM   3732 N N   . PHE B 1 177 ? -8.263  -46.511 14.001 1.00 120.42 ? 209 PHE B N   1 ? 
ATOM   3733 C CA  . PHE B 1 177 ? -7.313  -47.604 14.186 1.00 120.11 ? 209 PHE B CA  1 ? 
ATOM   3734 C C   . PHE B 1 177 ? -7.550  -48.233 15.562 1.00 119.12 ? 209 PHE B C   1 ? 
ATOM   3735 O O   . PHE B 1 177 ? -7.838  -47.536 16.531 1.00 124.00 ? 209 PHE B O   1 ? 
ATOM   3736 C CB  . PHE B 1 177 ? -5.861  -47.175 13.894 1.00 99.76  ? 209 PHE B CB  1 ? 
ATOM   3737 C CG  . PHE B 1 177 ? -4.910  -47.015 15.074 1.00 95.63  ? 209 PHE B CG  1 ? 
ATOM   3738 C CD1 . PHE B 1 177 ? -4.480  -48.127 15.788 1.00 108.51 ? 209 PHE B CD1 1 ? 
ATOM   3739 C CD2 . PHE B 1 177 ? -4.398  -45.773 15.435 1.00 90.64  ? 209 PHE B CD2 1 ? 
ATOM   3740 C CE1 . PHE B 1 177 ? -3.609  -47.995 16.859 1.00 112.03 ? 209 PHE B CE1 1 ? 
ATOM   3741 C CE2 . PHE B 1 177 ? -3.528  -45.645 16.508 1.00 98.30  ? 209 PHE B CE2 1 ? 
ATOM   3742 C CZ  . PHE B 1 177 ? -3.133  -46.757 17.215 1.00 107.15 ? 209 PHE B CZ  1 ? 
ATOM   3743 N N   . GLY B 1 178 ? -7.462  -49.570 15.614 1.00 129.95 ? 210 GLY B N   1 ? 
ATOM   3744 C CA  . GLY B 1 178 ? -7.432  -50.311 16.870 1.00 131.09 ? 210 GLY B CA  1 ? 
ATOM   3745 C C   . GLY B 1 178 ? -8.449  -51.452 16.946 1.00 128.23 ? 210 GLY B C   1 ? 
ATOM   3746 O O   . GLY B 1 178 ? -8.700  -51.957 18.042 1.00 109.89 ? 210 GLY B O   1 ? 
ATOM   3747 N N   . VAL B 1 179 ? -9.010  -51.849 15.789 1.00 132.32 ? 211 VAL B N   1 ? 
ATOM   3748 C CA  . VAL B 1 179 ? -10.001 -52.917 15.674 1.00 137.41 ? 211 VAL B CA  1 ? 
ATOM   3749 C C   . VAL B 1 179 ? -9.651  -54.064 16.626 1.00 146.30 ? 211 VAL B C   1 ? 
ATOM   3750 O O   . VAL B 1 179 ? -8.475  -54.410 16.760 1.00 142.98 ? 211 VAL B O   1 ? 
ATOM   3751 C CB  . VAL B 1 179 ? -10.128 -53.409 14.215 1.00 137.66 ? 211 VAL B CB  1 ? 
ATOM   3752 C CG1 . VAL B 1 179 ? -8.837  -53.236 13.416 1.00 137.06 ? 211 VAL B CG1 1 ? 
ATOM   3753 C CG2 . VAL B 1 179 ? -10.613 -54.854 14.135 1.00 140.04 ? 211 VAL B CG2 1 ? 
ATOM   3754 N N   . SER B 1 180 ? -10.690 -54.647 17.258 1.00 149.04 ? 212 SER B N   1 ? 
ATOM   3755 C CA  . SER B 1 180 ? -10.576 -55.642 18.326 1.00 143.73 ? 212 SER B CA  1 ? 
ATOM   3756 C C   . SER B 1 180 ? -9.967  -55.004 19.583 1.00 143.26 ? 212 SER B C   1 ? 
ATOM   3757 O O   . SER B 1 180 ? -10.311 -53.875 19.927 1.00 155.50 ? 212 SER B O   1 ? 
ATOM   3758 C CB  . SER B 1 180 ? -9.840  -56.913 17.878 1.00 131.77 ? 212 SER B CB  1 ? 
ATOM   3759 O OG  . SER B 1 180 ? -8.434  -56.876 18.113 1.00 124.02 ? 212 SER B OG  1 ? 
ATOM   3760 N N   . GLY B 1 181 ? -9.093  -55.740 20.286 1.00 137.84 ? 213 GLY B N   1 ? 
ATOM   3761 C CA  . GLY B 1 181 ? -8.332  -55.212 21.411 1.00 143.12 ? 213 GLY B CA  1 ? 
ATOM   3762 C C   . GLY B 1 181 ? -7.328  -56.245 21.930 1.00 143.24 ? 213 GLY B C   1 ? 
ATOM   3763 O O   . GLY B 1 181 ? -7.712  -57.382 22.214 1.00 131.58 ? 213 GLY B O   1 ? 
ATOM   3764 N N   . GLN B 1 182 ? -6.044  -55.853 22.017 1.00 122.50 ? 214 GLN B N   1 ? 
ATOM   3765 C CA  . GLN B 1 182 ? -5.004  -56.694 22.598 1.00 125.54 ? 214 GLN B CA  1 ? 
ATOM   3766 C C   . GLN B 1 182 ? -3.634  -56.069 22.286 1.00 109.82 ? 214 GLN B C   1 ? 
ATOM   3767 O O   . GLN B 1 182 ? -3.347  -55.947 21.079 1.00 99.56  ? 214 GLN B O   1 ? 
ATOM   3768 C CB  . GLN B 1 182 ? -4.978  -58.134 22.072 1.00 129.45 ? 214 GLN B CB  1 ? 
ATOM   3769 C CG  . GLN B 1 182 ? -4.895  -59.203 23.158 1.00 128.97 ? 214 GLN B CG  1 ? 
ATOM   3770 C CD  . GLN B 1 182 ? -6.259  -59.702 23.583 1.00 130.65 ? 214 GLN B CD  1 ? 
ATOM   3771 O OE1 . GLN B 1 182 ? -6.645  -60.843 23.298 1.00 118.45 ? 214 GLN B OE1 1 ? 
ATOM   3772 N NE2 . GLN B 1 182 ? -7.022  -58.838 24.238 1.00 125.54 ? 214 GLN B NE2 1 ? 
ATOM   3773 N N   . THR B 1 194 ? -5.873  -34.828 32.777 1.00 143.63 ? 226 THR B N   1 ? 
ATOM   3774 C CA  . THR B 1 194 ? -7.026  -35.249 31.944 1.00 138.58 ? 226 THR B CA  1 ? 
ATOM   3775 C C   . THR B 1 194 ? -7.592  -36.568 32.495 1.00 139.30 ? 226 THR B C   1 ? 
ATOM   3776 O O   . THR B 1 194 ? -7.946  -36.644 33.674 1.00 123.04 ? 226 THR B O   1 ? 
ATOM   3777 C CB  . THR B 1 194 ? -6.592  -35.314 30.473 1.00 132.30 ? 226 THR B CB  1 ? 
ATOM   3778 O OG1 . THR B 1 194 ? -5.624  -36.352 30.359 1.00 138.45 ? 226 THR B OG1 1 ? 
ATOM   3779 C CG2 . THR B 1 194 ? -5.984  -34.018 29.957 1.00 122.60 ? 226 THR B CG2 1 ? 
ATOM   3780 N N   . ARG B 1 195 ? -7.701  -37.594 31.635 1.00 143.35 ? 227 ARG B N   1 ? 
ATOM   3781 C CA  . ARG B 1 195 ? -8.097  -38.947 32.018 1.00 142.37 ? 227 ARG B CA  1 ? 
ATOM   3782 C C   . ARG B 1 195 ? -9.617  -39.059 32.204 1.00 127.09 ? 227 ARG B C   1 ? 
ATOM   3783 O O   . ARG B 1 195 ? -10.205 -38.270 32.942 1.00 105.34 ? 227 ARG B O   1 ? 
ATOM   3784 C CB  . ARG B 1 195 ? -7.313  -39.463 33.237 1.00 150.97 ? 227 ARG B CB  1 ? 
ATOM   3785 C CG  . ARG B 1 195 ? -6.057  -40.230 32.841 1.00 158.14 ? 227 ARG B CG  1 ? 
ATOM   3786 C CD  . ARG B 1 195 ? -6.400  -41.467 32.018 1.00 165.48 ? 227 ARG B CD  1 ? 
ATOM   3787 N NE  . ARG B 1 195 ? -6.579  -42.666 32.846 1.00 178.18 ? 227 ARG B NE  1 ? 
ATOM   3788 C CZ  . ARG B 1 195 ? -7.737  -43.254 33.157 1.00 183.54 ? 227 ARG B CZ  1 ? 
ATOM   3789 N NH1 . ARG B 1 195 ? -7.738  -44.413 33.795 1.00 180.74 ? 227 ARG B NH1 1 ? 
ATOM   3790 N NH2 . ARG B 1 195 ? -8.893  -42.702 32.824 1.00 184.87 ? 227 ARG B NH2 1 ? 
ATOM   3791 N N   . SER B 1 196 ? -10.217 -40.061 31.528 1.00 119.37 ? 228 SER B N   1 ? 
ATOM   3792 C CA  . SER B 1 196 ? -11.633 -40.435 31.573 1.00 118.53 ? 228 SER B CA  1 ? 
ATOM   3793 C C   . SER B 1 196 ? -12.218 -40.353 30.162 1.00 112.45 ? 228 SER B C   1 ? 
ATOM   3794 O O   . SER B 1 196 ? -12.075 -41.314 29.402 1.00 124.73 ? 228 SER B O   1 ? 
ATOM   3795 C CB  . SER B 1 196 ? -12.473 -39.666 32.582 1.00 121.21 ? 228 SER B CB  1 ? 
ATOM   3796 O OG  . SER B 1 196 ? -13.259 -38.654 31.942 1.00 101.67 ? 228 SER B OG  1 ? 
ATOM   3797 N N   . TYR B 1 197 ? -12.857 -39.220 29.820 1.00 88.40  ? 229 TYR B N   1 ? 
ATOM   3798 C CA  . TYR B 1 197 ? -13.581 -39.064 28.558 1.00 92.58  ? 229 TYR B CA  1 ? 
ATOM   3799 C C   . TYR B 1 197 ? -14.589 -40.200 28.381 1.00 90.63  ? 229 TYR B C   1 ? 
ATOM   3800 O O   . TYR B 1 197 ? -15.122 -40.384 27.282 1.00 89.95  ? 229 TYR B O   1 ? 
ATOM   3801 C CB  . TYR B 1 197 ? -12.621 -38.955 27.364 1.00 80.69  ? 229 TYR B CB  1 ? 
ATOM   3802 C CG  . TYR B 1 197 ? -11.605 -37.833 27.517 1.00 79.10  ? 229 TYR B CG  1 ? 
ATOM   3803 C CD1 . TYR B 1 197 ? -11.957 -36.513 27.264 1.00 80.03  ? 229 TYR B CD1 1 ? 
ATOM   3804 C CD2 . TYR B 1 197 ? -10.309 -38.091 27.948 1.00 74.50  ? 229 TYR B CD2 1 ? 
ATOM   3805 C CE1 . TYR B 1 197 ? -11.047 -35.481 27.418 1.00 76.53  ? 229 TYR B CE1 1 ? 
ATOM   3806 C CE2 . TYR B 1 197 ? -9.395  -37.065 28.123 1.00 84.47  ? 229 TYR B CE2 1 ? 
ATOM   3807 C CZ  . TYR B 1 197 ? -9.762  -35.759 27.844 1.00 83.55  ? 229 TYR B CZ  1 ? 
ATOM   3808 O OH  . TYR B 1 197 ? -8.855  -34.753 27.989 1.00 83.27  ? 229 TYR B OH  1 ? 
ATOM   3809 N N   . MET B 1 198 ? -14.885 -40.916 29.475 1.00 102.22 ? 230 MET B N   1 ? 
ATOM   3810 C CA  . MET B 1 198 ? -15.754 -42.075 29.412 1.00 103.33 ? 230 MET B CA  1 ? 
ATOM   3811 C C   . MET B 1 198 ? -17.121 -41.664 29.954 1.00 98.10  ? 230 MET B C   1 ? 
ATOM   3812 O O   . MET B 1 198 ? -17.205 -41.129 31.060 1.00 88.31  ? 230 MET B O   1 ? 
ATOM   3813 C CB  . MET B 1 198 ? -15.148 -43.240 30.202 1.00 111.38 ? 230 MET B CB  1 ? 
ATOM   3814 C CG  . MET B 1 198 ? -15.593 -44.597 29.694 1.00 124.29 ? 230 MET B CG  1 ? 
ATOM   3815 S SD  . MET B 1 198 ? -14.395 -45.918 29.966 1.00 134.10 ? 230 MET B SD  1 ? 
ATOM   3816 C CE  . MET B 1 198 ? -14.986 -47.133 28.776 1.00 126.89 ? 230 MET B CE  1 ? 
ATOM   3817 N N   . SER B 1 199 ? -18.175 -41.897 29.155 1.00 89.81  ? 231 SER B N   1 ? 
ATOM   3818 C CA  . SER B 1 199 ? -19.538 -41.542 29.534 1.00 94.99  ? 231 SER B CA  1 ? 
ATOM   3819 C C   . SER B 1 199 ? -19.953 -42.271 30.812 1.00 89.23  ? 231 SER B C   1 ? 
ATOM   3820 O O   . SER B 1 199 ? -19.479 -43.372 31.074 1.00 92.37  ? 231 SER B O   1 ? 
ATOM   3821 C CB  . SER B 1 199 ? -20.512 -41.817 28.408 1.00 94.65  ? 231 SER B CB  1 ? 
ATOM   3822 O OG  . SER B 1 199 ? -20.401 -43.151 27.928 1.00 84.11  ? 231 SER B OG  1 ? 
ATOM   3823 N N   . PRO B 1 200 ? -20.854 -41.697 31.644 1.00 96.49  ? 232 PRO B N   1 ? 
ATOM   3824 C CA  . PRO B 1 200 ? -21.200 -42.292 32.940 1.00 103.69 ? 232 PRO B CA  1 ? 
ATOM   3825 C C   . PRO B 1 200 ? -21.781 -43.701 32.831 1.00 109.49 ? 232 PRO B C   1 ? 
ATOM   3826 O O   . PRO B 1 200 ? -21.579 -44.532 33.715 1.00 100.76 ? 232 PRO B O   1 ? 
ATOM   3827 C CB  . PRO B 1 200 ? -22.224 -41.302 33.537 1.00 107.68 ? 232 PRO B CB  1 ? 
ATOM   3828 C CG  . PRO B 1 200 ? -21.996 -40.013 32.785 1.00 110.42 ? 232 PRO B CG  1 ? 
ATOM   3829 C CD  . PRO B 1 200 ? -21.601 -40.456 31.385 1.00 108.92 ? 232 PRO B CD  1 ? 
ATOM   3830 N N   . GLU B 1 201 ? -22.503 -43.954 31.734 1.00 107.09 ? 233 GLU B N   1 ? 
ATOM   3831 C CA  . GLU B 1 201 ? -23.127 -45.243 31.499 1.00 105.64 ? 233 GLU B CA  1 ? 
ATOM   3832 C C   . GLU B 1 201 ? -22.064 -46.312 31.221 1.00 112.76 ? 233 GLU B C   1 ? 
ATOM   3833 O O   . GLU B 1 201 ? -22.252 -47.468 31.590 1.00 122.15 ? 233 GLU B O   1 ? 
ATOM   3834 C CB  . GLU B 1 201 ? -24.202 -45.129 30.412 1.00 101.99 ? 233 GLU B CB  1 ? 
ATOM   3835 C CG  . GLU B 1 201 ? -23.704 -44.750 29.017 1.00 100.34 ? 233 GLU B CG  1 ? 
ATOM   3836 C CD  . GLU B 1 201 ? -23.631 -43.270 28.656 1.00 99.41  ? 233 GLU B CD  1 ? 
ATOM   3837 O OE1 . GLU B 1 201 ? -23.866 -42.393 29.519 1.00 89.96  ? 233 GLU B OE1 1 ? 
ATOM   3838 O OE2 . GLU B 1 201 ? -23.337 -42.995 27.466 1.00 98.86  ? 233 GLU B OE2 1 ? 
ATOM   3839 N N   . ARG B 1 202 ? -20.954 -45.937 30.570 1.00 118.92 ? 234 ARG B N   1 ? 
ATOM   3840 C CA  . ARG B 1 202 ? -19.875 -46.879 30.299 1.00 117.89 ? 234 ARG B CA  1 ? 
ATOM   3841 C C   . ARG B 1 202 ? -19.109 -47.166 31.592 1.00 115.61 ? 234 ARG B C   1 ? 
ATOM   3842 O O   . ARG B 1 202 ? -18.478 -48.213 31.709 1.00 107.47 ? 234 ARG B O   1 ? 
ATOM   3843 C CB  . ARG B 1 202 ? -18.903 -46.416 29.202 1.00 117.35 ? 234 ARG B CB  1 ? 
ATOM   3844 C CG  . ARG B 1 202 ? -19.302 -46.666 27.753 1.00 114.59 ? 234 ARG B CG  1 ? 
ATOM   3845 C CD  . ARG B 1 202 ? -18.145 -46.372 26.791 1.00 121.39 ? 234 ARG B CD  1 ? 
ATOM   3846 N NE  . ARG B 1 202 ? -17.809 -44.943 26.724 1.00 138.63 ? 234 ARG B NE  1 ? 
ATOM   3847 C CZ  . ARG B 1 202 ? -16.721 -44.387 26.176 1.00 140.20 ? 234 ARG B CZ  1 ? 
ATOM   3848 N NH1 . ARG B 1 202 ? -16.634 -43.069 26.073 1.00 135.81 ? 234 ARG B NH1 1 ? 
ATOM   3849 N NH2 . ARG B 1 202 ? -15.729 -45.135 25.718 1.00 137.27 ? 234 ARG B NH2 1 ? 
ATOM   3850 N N   . LEU B 1 203 ? -19.156 -46.235 32.555 1.00 116.07 ? 235 LEU B N   1 ? 
ATOM   3851 C CA  . LEU B 1 203 ? -18.576 -46.477 33.868 1.00 124.79 ? 235 LEU B CA  1 ? 
ATOM   3852 C C   . LEU B 1 203 ? -19.506 -47.384 34.671 1.00 135.39 ? 235 LEU B C   1 ? 
ATOM   3853 O O   . LEU B 1 203 ? -19.100 -47.915 35.700 1.00 137.41 ? 235 LEU B O   1 ? 
ATOM   3854 C CB  . LEU B 1 203 ? -18.288 -45.180 34.623 1.00 126.99 ? 235 LEU B CB  1 ? 
ATOM   3855 C CG  . LEU B 1 203 ? -17.302 -44.202 33.974 1.00 128.34 ? 235 LEU B CG  1 ? 
ATOM   3856 C CD1 . LEU B 1 203 ? -16.957 -43.126 34.991 1.00 126.30 ? 235 LEU B CD1 1 ? 
ATOM   3857 C CD2 . LEU B 1 203 ? -16.033 -44.850 33.442 1.00 126.56 ? 235 LEU B CD2 1 ? 
ATOM   3858 N N   . GLN B 1 204 ? -20.762 -47.514 34.215 1.00 148.21 ? 236 GLN B N   1 ? 
ATOM   3859 C CA  . GLN B 1 204 ? -21.675 -48.546 34.684 1.00 142.05 ? 236 GLN B CA  1 ? 
ATOM   3860 C C   . GLN B 1 204 ? -21.557 -49.754 33.735 1.00 124.03 ? 236 GLN B C   1 ? 
ATOM   3861 O O   . GLN B 1 204 ? -21.556 -50.893 34.244 1.00 114.37 ? 236 GLN B O   1 ? 
ATOM   3862 C CB  . GLN B 1 204 ? -23.129 -48.061 34.714 1.00 143.41 ? 236 GLN B CB  1 ? 
ATOM   3863 C CG  . GLN B 1 204 ? -23.364 -46.733 35.431 1.00 138.28 ? 236 GLN B CG  1 ? 
ATOM   3864 C CD  . GLN B 1 204 ? -23.565 -46.866 36.926 1.00 140.69 ? 236 GLN B CD  1 ? 
ATOM   3865 O OE1 . GLN B 1 204 ? -22.736 -47.444 37.638 1.00 142.39 ? 236 GLN B OE1 1 ? 
ATOM   3866 N NE2 . GLN B 1 204 ? -24.670 -46.323 37.421 1.00 138.23 ? 236 GLN B NE2 1 ? 
ATOM   3867 N N   . HIS B 1 207 ? -21.189 -51.972 25.771 1.00 167.04 ? 239 HIS B N   1 ? 
ATOM   3868 C CA  . HIS B 1 207 ? -20.619 -52.780 24.654 1.00 166.20 ? 239 HIS B CA  1 ? 
ATOM   3869 C C   . HIS B 1 207 ? -20.336 -51.909 23.427 1.00 169.94 ? 239 HIS B C   1 ? 
ATOM   3870 O O   . HIS B 1 207 ? -19.361 -52.162 22.722 1.00 159.83 ? 239 HIS B O   1 ? 
ATOM   3871 C CB  . HIS B 1 207 ? -21.522 -53.974 24.318 1.00 166.48 ? 239 HIS B CB  1 ? 
ATOM   3872 C CG  . HIS B 1 207 ? -22.896 -53.615 23.849 1.00 170.38 ? 239 HIS B CG  1 ? 
ATOM   3873 N ND1 . HIS B 1 207 ? -23.152 -53.078 22.604 1.00 169.08 ? 239 HIS B ND1 1 ? 
ATOM   3874 C CD2 . HIS B 1 207 ? -24.086 -53.714 24.459 1.00 165.61 ? 239 HIS B CD2 1 ? 
ATOM   3875 C CE1 . HIS B 1 207 ? -24.454 -52.867 22.476 1.00 168.85 ? 239 HIS B CE1 1 ? 
ATOM   3876 N NE2 . HIS B 1 207 ? -25.041 -53.249 23.590 1.00 166.47 ? 239 HIS B NE2 1 ? 
ATOM   3877 N N   . TYR B 1 208 ? -21.193 -50.904 23.171 1.00 173.87 ? 240 TYR B N   1 ? 
ATOM   3878 C CA  . TYR B 1 208 ? -21.098 -50.060 21.986 1.00 167.74 ? 240 TYR B CA  1 ? 
ATOM   3879 C C   . TYR B 1 208 ? -22.260 -49.063 21.937 1.00 159.66 ? 240 TYR B C   1 ? 
ATOM   3880 O O   . TYR B 1 208 ? -23.419 -49.478 21.930 1.00 172.41 ? 240 TYR B O   1 ? 
ATOM   3881 C CB  . TYR B 1 208 ? -21.103 -50.968 20.748 1.00 170.53 ? 240 TYR B CB  1 ? 
ATOM   3882 C CG  . TYR B 1 208 ? -21.781 -50.362 19.528 1.00 176.82 ? 240 TYR B CG  1 ? 
ATOM   3883 C CD1 . TYR B 1 208 ? -21.438 -49.094 19.073 1.00 178.45 ? 240 TYR B CD1 1 ? 
ATOM   3884 C CD2 . TYR B 1 208 ? -22.803 -51.035 18.867 1.00 177.35 ? 240 TYR B CD2 1 ? 
ATOM   3885 C CE1 . TYR B 1 208 ? -22.068 -48.527 17.977 1.00 179.84 ? 240 TYR B CE1 1 ? 
ATOM   3886 C CE2 . TYR B 1 208 ? -23.439 -50.479 17.768 1.00 175.59 ? 240 TYR B CE2 1 ? 
ATOM   3887 C CZ  . TYR B 1 208 ? -23.069 -49.222 17.322 1.00 178.63 ? 240 TYR B CZ  1 ? 
ATOM   3888 O OH  . TYR B 1 208 ? -23.686 -48.664 16.240 1.00 181.37 ? 240 TYR B OH  1 ? 
ATOM   3889 N N   . SER B 1 209 ? -21.948 -47.756 21.875 1.00 140.35 ? 241 SER B N   1 ? 
ATOM   3890 C CA  . SER B 1 209 ? -22.940 -46.723 21.593 1.00 123.44 ? 241 SER B CA  1 ? 
ATOM   3891 C C   . SER B 1 209 ? -22.273 -45.402 21.202 1.00 110.88 ? 241 SER B C   1 ? 
ATOM   3892 O O   . SER B 1 209 ? -21.186 -45.070 21.675 1.00 97.82  ? 241 SER B O   1 ? 
ATOM   3893 C CB  . SER B 1 209 ? -23.876 -46.503 22.762 1.00 116.32 ? 241 SER B CB  1 ? 
ATOM   3894 O OG  . SER B 1 209 ? -24.844 -45.504 22.459 1.00 100.81 ? 241 SER B OG  1 ? 
ATOM   3895 N N   . VAL B 1 210 ? -22.970 -44.628 20.362 1.00 94.20  ? 242 VAL B N   1 ? 
ATOM   3896 C CA  . VAL B 1 210 ? -22.501 -43.312 19.956 1.00 90.44  ? 242 VAL B CA  1 ? 
ATOM   3897 C C   . VAL B 1 210 ? -22.730 -42.295 21.075 1.00 87.74  ? 242 VAL B C   1 ? 
ATOM   3898 O O   . VAL B 1 210 ? -21.990 -41.324 21.195 1.00 87.49  ? 242 VAL B O   1 ? 
ATOM   3899 C CB  . VAL B 1 210 ? -23.186 -42.877 18.648 1.00 88.76  ? 242 VAL B CB  1 ? 
ATOM   3900 C CG1 . VAL B 1 210 ? -24.594 -42.345 18.884 1.00 92.75  ? 242 VAL B CG1 1 ? 
ATOM   3901 C CG2 . VAL B 1 210 ? -22.355 -41.853 17.894 1.00 96.07  ? 242 VAL B CG2 1 ? 
ATOM   3902 N N   . GLN B 1 211 ? -23.740 -42.514 21.919 1.00 88.86  ? 243 GLN B N   1 ? 
ATOM   3903 C CA  . GLN B 1 211 ? -24.065 -41.538 22.944 1.00 91.88  ? 243 GLN B CA  1 ? 
ATOM   3904 C C   . GLN B 1 211 ? -22.869 -41.294 23.858 1.00 85.67  ? 243 GLN B C   1 ? 
ATOM   3905 O O   . GLN B 1 211 ? -22.810 -40.263 24.521 1.00 105.20 ? 243 GLN B O   1 ? 
ATOM   3906 C CB  . GLN B 1 211 ? -25.307 -41.950 23.734 1.00 95.54  ? 243 GLN B CB  1 ? 
ATOM   3907 C CG  . GLN B 1 211 ? -26.584 -41.902 22.901 1.00 103.35 ? 243 GLN B CG  1 ? 
ATOM   3908 C CD  . GLN B 1 211 ? -26.793 -40.568 22.215 1.00 96.54  ? 243 GLN B CD  1 ? 
ATOM   3909 O OE1 . GLN B 1 211 ? -26.798 -40.459 20.982 1.00 91.99  ? 243 GLN B OE1 1 ? 
ATOM   3910 N NE2 . GLN B 1 211 ? -26.944 -39.530 23.021 1.00 97.37  ? 243 GLN B NE2 1 ? 
ATOM   3911 N N   . SER B 1 212 ? -21.928 -42.239 23.897 1.00 83.52  ? 244 SER B N   1 ? 
ATOM   3912 C CA  . SER B 1 212 ? -20.767 -42.125 24.765 1.00 86.57  ? 244 SER B CA  1 ? 
ATOM   3913 C C   . SER B 1 212 ? -19.734 -41.180 24.144 1.00 75.85  ? 244 SER B C   1 ? 
ATOM   3914 O O   . SER B 1 212 ? -19.207 -40.305 24.829 1.00 69.99  ? 244 SER B O   1 ? 
ATOM   3915 C CB  . SER B 1 212 ? -20.194 -43.484 25.069 1.00 85.32  ? 244 SER B CB  1 ? 
ATOM   3916 O OG  . SER B 1 212 ? -20.062 -44.245 23.878 1.00 91.86  ? 244 SER B OG  1 ? 
ATOM   3917 N N   . ASP B 1 213 ? -19.479 -41.337 22.840 1.00 66.37  ? 245 ASP B N   1 ? 
ATOM   3918 C CA  . ASP B 1 213 ? -18.696 -40.374 22.081 1.00 75.70  ? 245 ASP B CA  1 ? 
ATOM   3919 C C   . ASP B 1 213 ? -19.204 -38.954 22.316 1.00 79.99  ? 245 ASP B C   1 ? 
ATOM   3920 O O   . ASP B 1 213 ? -18.449 -38.098 22.776 1.00 80.47  ? 245 ASP B O   1 ? 
ATOM   3921 C CB  . ASP B 1 213 ? -18.698 -40.699 20.598 1.00 78.22  ? 245 ASP B CB  1 ? 
ATOM   3922 C CG  . ASP B 1 213 ? -18.065 -42.034 20.247 1.00 85.13  ? 245 ASP B CG  1 ? 
ATOM   3923 O OD1 . ASP B 1 213 ? -17.342 -42.579 21.107 1.00 95.50  ? 245 ASP B OD1 1 ? 
ATOM   3924 O OD2 . ASP B 1 213 ? -18.331 -42.535 19.139 1.00 97.81  ? 245 ASP B OD2 1 ? 
ATOM   3925 N N   . ILE B 1 214 ? -20.486 -38.719 22.011 1.00 81.05  ? 246 ILE B N   1 ? 
ATOM   3926 C CA  . ILE B 1 214 ? -21.076 -37.396 22.139 1.00 82.33  ? 246 ILE B CA  1 ? 
ATOM   3927 C C   . ILE B 1 214 ? -20.727 -36.812 23.501 1.00 76.89  ? 246 ILE B C   1 ? 
ATOM   3928 O O   . ILE B 1 214 ? -20.402 -35.628 23.585 1.00 79.74  ? 246 ILE B O   1 ? 
ATOM   3929 C CB  . ILE B 1 214 ? -22.595 -37.440 21.900 1.00 88.33  ? 246 ILE B CB  1 ? 
ATOM   3930 C CG1 . ILE B 1 214 ? -22.889 -37.567 20.413 1.00 88.20  ? 246 ILE B CG1 1 ? 
ATOM   3931 C CG2 . ILE B 1 214 ? -23.314 -36.236 22.520 1.00 85.59  ? 246 ILE B CG2 1 ? 
ATOM   3932 C CD1 . ILE B 1 214 ? -24.255 -38.158 20.139 1.00 89.91  ? 246 ILE B CD1 1 ? 
ATOM   3933 N N   . TRP B 1 215 ? -20.787 -37.635 24.554 1.00 64.83  ? 247 TRP B N   1 ? 
ATOM   3934 C CA  . TRP B 1 215 ? -20.390 -37.165 25.876 1.00 74.65  ? 247 TRP B CA  1 ? 
ATOM   3935 C C   . TRP B 1 215 ? -18.901 -36.794 25.904 1.00 74.62  ? 247 TRP B C   1 ? 
ATOM   3936 O O   . TRP B 1 215 ? -18.524 -35.766 26.466 1.00 67.67  ? 247 TRP B O   1 ? 
ATOM   3937 C CB  . TRP B 1 215 ? -20.722 -38.207 26.954 1.00 71.14  ? 247 TRP B CB  1 ? 
ATOM   3938 C CG  . TRP B 1 215 ? -19.915 -38.031 28.209 1.00 68.42  ? 247 TRP B CG  1 ? 
ATOM   3939 C CD1 . TRP B 1 215 ? -18.600 -38.348 28.395 1.00 60.24  ? 247 TRP B CD1 1 ? 
ATOM   3940 C CD2 . TRP B 1 215 ? -20.378 -37.460 29.451 1.00 62.63  ? 247 TRP B CD2 1 ? 
ATOM   3941 N NE1 . TRP B 1 215 ? -18.217 -38.021 29.672 1.00 64.01  ? 247 TRP B NE1 1 ? 
ATOM   3942 C CE2 . TRP B 1 215 ? -19.281 -37.473 30.340 1.00 60.05  ? 247 TRP B CE2 1 ? 
ATOM   3943 C CE3 . TRP B 1 215 ? -21.598 -36.940 29.889 1.00 64.07  ? 247 TRP B CE3 1 ? 
ATOM   3944 C CZ2 . TRP B 1 215 ? -19.377 -36.982 31.639 1.00 63.58  ? 247 TRP B CZ2 1 ? 
ATOM   3945 C CZ3 . TRP B 1 215 ? -21.690 -36.454 31.177 1.00 63.44  ? 247 TRP B CZ3 1 ? 
ATOM   3946 C CH2 . TRP B 1 215 ? -20.592 -36.464 32.032 1.00 63.17  ? 247 TRP B CH2 1 ? 
ATOM   3947 N N   . SER B 1 216 ? -18.047 -37.633 25.310 1.00 71.23  ? 248 SER B N   1 ? 
ATOM   3948 C CA  . SER B 1 216 ? -16.623 -37.340 25.248 1.00 74.52  ? 248 SER B CA  1 ? 
ATOM   3949 C C   . SER B 1 216 ? -16.405 -36.021 24.513 1.00 69.82  ? 248 SER B C   1 ? 
ATOM   3950 O O   . SER B 1 216 ? -15.723 -35.133 25.024 1.00 64.69  ? 248 SER B O   1 ? 
ATOM   3951 C CB  . SER B 1 216 ? -15.865 -38.448 24.582 1.00 72.28  ? 248 SER B CB  1 ? 
ATOM   3952 O OG  . SER B 1 216 ? -16.319 -39.698 25.068 1.00 90.04  ? 248 SER B OG  1 ? 
ATOM   3953 N N   . MET B 1 217 ? -17.010 -35.916 23.319 1.00 62.88  ? 249 MET B N   1 ? 
ATOM   3954 C CA  . MET B 1 217 ? -16.929 -34.712 22.506 1.00 62.81  ? 249 MET B CA  1 ? 
ATOM   3955 C C   . MET B 1 217 ? -17.288 -33.504 23.356 1.00 63.31  ? 249 MET B C   1 ? 
ATOM   3956 O O   . MET B 1 217 ? -16.622 -32.483 23.316 1.00 66.90  ? 249 MET B O   1 ? 
ATOM   3957 C CB  . MET B 1 217 ? -17.899 -34.742 21.325 1.00 60.53  ? 249 MET B CB  1 ? 
ATOM   3958 C CG  . MET B 1 217 ? -17.905 -33.446 20.540 1.00 69.73  ? 249 MET B CG  1 ? 
ATOM   3959 S SD  . MET B 1 217 ? -18.840 -33.504 18.995 1.00 68.95  ? 249 MET B SD  1 ? 
ATOM   3960 C CE  . MET B 1 217 ? -20.462 -33.313 19.737 1.00 71.21  ? 249 MET B CE  1 ? 
ATOM   3961 N N   . GLY B 1 218 ? -18.355 -33.643 24.132 1.00 66.51  ? 250 GLY B N   1 ? 
ATOM   3962 C CA  . GLY B 1 218 ? -18.837 -32.537 24.923 1.00 66.18  ? 250 GLY B CA  1 ? 
ATOM   3963 C C   . GLY B 1 218 ? -17.800 -32.139 25.960 1.00 58.26  ? 250 GLY B C   1 ? 
ATOM   3964 O O   . GLY B 1 218 ? -17.595 -30.955 26.219 1.00 63.57  ? 250 GLY B O   1 ? 
ATOM   3965 N N   . LEU B 1 219 ? -17.214 -33.149 26.596 1.00 57.98  ? 251 LEU B N   1 ? 
ATOM   3966 C CA  . LEU B 1 219 ? -16.272 -32.903 27.670 1.00 66.20  ? 251 LEU B CA  1 ? 
ATOM   3967 C C   . LEU B 1 219 ? -15.006 -32.276 27.085 1.00 60.47  ? 251 LEU B C   1 ? 
ATOM   3968 O O   . LEU B 1 219 ? -14.356 -31.460 27.720 1.00 54.54  ? 251 LEU B O   1 ? 
ATOM   3969 C CB  . LEU B 1 219 ? -16.019 -34.243 28.350 1.00 74.28  ? 251 LEU B CB  1 ? 
ATOM   3970 C CG  . LEU B 1 219 ? -15.088 -34.207 29.561 1.00 84.30  ? 251 LEU B CG  1 ? 
ATOM   3971 C CD1 . LEU B 1 219 ? -15.770 -33.569 30.755 1.00 85.84  ? 251 LEU B CD1 1 ? 
ATOM   3972 C CD2 . LEU B 1 219 ? -14.620 -35.616 29.871 1.00 86.12  ? 251 LEU B CD2 1 ? 
ATOM   3973 N N   . SER B 1 220 ? -14.707 -32.612 25.831 1.00 54.82  ? 252 SER B N   1 ? 
ATOM   3974 C CA  . SER B 1 220 ? -13.527 -32.109 25.152 1.00 61.43  ? 252 SER B CA  1 ? 
ATOM   3975 C C   . SER B 1 220 ? -13.672 -30.628 24.792 1.00 62.82  ? 252 SER B C   1 ? 
ATOM   3976 O O   . SER B 1 220 ? -12.722 -29.849 24.950 1.00 56.59  ? 252 SER B O   1 ? 
ATOM   3977 C CB  . SER B 1 220 ? -13.235 -32.964 23.950 1.00 63.43  ? 252 SER B CB  1 ? 
ATOM   3978 O OG  . SER B 1 220 ? -12.840 -34.255 24.399 1.00 66.74  ? 252 SER B OG  1 ? 
ATOM   3979 N N   . LEU B 1 221 ? -14.858 -30.257 24.296 1.00 57.03  ? 253 LEU B N   1 ? 
ATOM   3980 C CA  . LEU B 1 221 ? -15.145 -28.884 23.924 1.00 51.02  ? 253 LEU B CA  1 ? 
ATOM   3981 C C   . LEU B 1 221 ? -15.067 -27.974 25.154 1.00 51.54  ? 253 LEU B C   1 ? 
ATOM   3982 O O   . LEU B 1 221 ? -14.602 -26.837 25.075 1.00 56.45  ? 253 LEU B O   1 ? 
ATOM   3983 C CB  . LEU B 1 221 ? -16.510 -28.837 23.251 1.00 53.76  ? 253 LEU B CB  1 ? 
ATOM   3984 C CG  . LEU B 1 221 ? -16.636 -29.550 21.900 1.00 57.01  ? 253 LEU B CG  1 ? 
ATOM   3985 C CD1 . LEU B 1 221 ? -18.124 -29.607 21.493 1.00 55.66  ? 253 LEU B CD1 1 ? 
ATOM   3986 C CD2 . LEU B 1 221 ? -15.830 -28.868 20.815 1.00 55.14  ? 253 LEU B CD2 1 ? 
ATOM   3987 N N   . VAL B 1 222 ? -15.497 -28.465 26.313 1.00 51.85  ? 254 VAL B N   1 ? 
ATOM   3988 C CA  . VAL B 1 222 ? -15.402 -27.651 27.515 1.00 57.76  ? 254 VAL B CA  1 ? 
ATOM   3989 C C   . VAL B 1 222 ? -13.923 -27.520 27.863 1.00 56.10  ? 254 VAL B C   1 ? 
ATOM   3990 O O   . VAL B 1 222 ? -13.477 -26.434 28.226 1.00 62.99  ? 254 VAL B O   1 ? 
ATOM   3991 C CB  . VAL B 1 222 ? -16.219 -28.188 28.711 1.00 58.73  ? 254 VAL B CB  1 ? 
ATOM   3992 C CG1 . VAL B 1 222 ? -15.986 -27.404 29.998 1.00 59.35  ? 254 VAL B CG1 1 ? 
ATOM   3993 C CG2 . VAL B 1 222 ? -17.703 -28.187 28.399 1.00 64.30  ? 254 VAL B CG2 1 ? 
ATOM   3994 N N   . GLU B 1 223 ? -13.180 -28.627 27.723 1.00 60.51  ? 255 GLU B N   1 ? 
ATOM   3995 C CA  . GLU B 1 223 ? -11.749 -28.648 27.989 1.00 62.31  ? 255 GLU B CA  1 ? 
ATOM   3996 C C   . GLU B 1 223 ? -11.024 -27.629 27.105 1.00 61.62  ? 255 GLU B C   1 ? 
ATOM   3997 O O   . GLU B 1 223 ? -10.289 -26.772 27.603 1.00 58.76  ? 255 GLU B O   1 ? 
ATOM   3998 C CB  . GLU B 1 223 ? -11.210 -30.060 27.783 1.00 63.90  ? 255 GLU B CB  1 ? 
ATOM   3999 C CG  . GLU B 1 223 ? -9.696  -30.144 27.962 1.00 72.62  ? 255 GLU B CG  1 ? 
ATOM   4000 C CD  . GLU B 1 223 ? -9.108  -31.542 27.894 1.00 73.25  ? 255 GLU B CD  1 ? 
ATOM   4001 O OE1 . GLU B 1 223 ? -9.896  -32.473 27.674 1.00 74.87  ? 255 GLU B OE1 1 ? 
ATOM   4002 O OE2 . GLU B 1 223 ? -7.878  -31.709 28.065 1.00 82.86  ? 255 GLU B OE2 1 ? 
ATOM   4003 N N   . MET B 1 224 ? -11.258 -27.709 25.791 1.00 54.77  ? 256 MET B N   1 ? 
ATOM   4004 C CA  . MET B 1 224 ? -10.577 -26.847 24.841 1.00 56.61  ? 256 MET B CA  1 ? 
ATOM   4005 C C   . MET B 1 224 ? -10.992 -25.386 25.025 1.00 58.68  ? 256 MET B C   1 ? 
ATOM   4006 O O   . MET B 1 224 ? -10.158 -24.488 24.916 1.00 55.76  ? 256 MET B O   1 ? 
ATOM   4007 C CB  . MET B 1 224 ? -10.807 -27.350 23.415 1.00 59.22  ? 256 MET B CB  1 ? 
ATOM   4008 C CG  . MET B 1 224 ? -10.097 -28.676 23.158 1.00 58.25  ? 256 MET B CG  1 ? 
ATOM   4009 S SD  . MET B 1 224 ? -10.269 -29.277 21.466 1.00 60.77  ? 256 MET B SD  1 ? 
ATOM   4010 C CE  . MET B 1 224 ? -11.975 -29.807 21.655 1.00 66.19  ? 256 MET B CE  1 ? 
ATOM   4011 N N   . ALA B 1 225 ? -12.260 -25.151 25.377 1.00 55.70  ? 257 ALA B N   1 ? 
ATOM   4012 C CA  . ALA B 1 225 ? -12.775 -23.801 25.524 1.00 50.98  ? 257 ALA B CA  1 ? 
ATOM   4013 C C   . ALA B 1 225 ? -12.262 -23.109 26.793 1.00 49.63  ? 257 ALA B C   1 ? 
ATOM   4014 O O   . ALA B 1 225 ? -12.099 -21.887 26.824 1.00 51.50  ? 257 ALA B O   1 ? 
ATOM   4015 C CB  . ALA B 1 225 ? -14.286 -23.872 25.505 1.00 54.75  ? 257 ALA B CB  1 ? 
ATOM   4016 N N   . VAL B 1 226 ? -12.028 -23.853 27.871 1.00 53.89  ? 258 VAL B N   1 ? 
ATOM   4017 C CA  . VAL B 1 226 ? -11.651 -23.215 29.128 1.00 63.61  ? 258 VAL B CA  1 ? 
ATOM   4018 C C   . VAL B 1 226 ? -10.160 -23.409 29.401 1.00 66.18  ? 258 VAL B C   1 ? 
ATOM   4019 O O   . VAL B 1 226 ? -9.605  -22.677 30.210 1.00 71.33  ? 258 VAL B O   1 ? 
ATOM   4020 C CB  . VAL B 1 226 ? -12.474 -23.683 30.346 1.00 61.50  ? 258 VAL B CB  1 ? 
ATOM   4021 C CG1 . VAL B 1 226 ? -13.968 -23.497 30.123 1.00 68.27  ? 258 VAL B CG1 1 ? 
ATOM   4022 C CG2 . VAL B 1 226 ? -12.193 -25.131 30.711 1.00 65.73  ? 258 VAL B CG2 1 ? 
ATOM   4023 N N   . GLY B 1 227 ? -9.533  -24.420 28.782 1.00 66.38  ? 259 GLY B N   1 ? 
ATOM   4024 C CA  . GLY B 1 227 ? -8.086  -24.568 28.850 1.00 68.31  ? 259 GLY B CA  1 ? 
ATOM   4025 C C   . GLY B 1 227 ? -7.602  -25.634 29.835 1.00 66.99  ? 259 GLY B C   1 ? 
ATOM   4026 O O   . GLY B 1 227 ? -6.395  -25.810 29.960 1.00 78.69  ? 259 GLY B O   1 ? 
ATOM   4027 N N   . ARG B 1 228 ? -8.516  -26.327 30.528 1.00 70.72  ? 260 ARG B N   1 ? 
ATOM   4028 C CA  . ARG B 1 228 ? -8.164  -27.419 31.427 1.00 74.03  ? 260 ARG B CA  1 ? 
ATOM   4029 C C   . ARG B 1 228 ? -9.262  -28.480 31.435 1.00 81.96  ? 260 ARG B C   1 ? 
ATOM   4030 O O   . ARG B 1 228 ? -10.417 -28.185 31.127 1.00 85.87  ? 260 ARG B O   1 ? 
ATOM   4031 C CB  . ARG B 1 228 ? -7.948  -26.957 32.873 1.00 77.28  ? 260 ARG B CB  1 ? 
ATOM   4032 C CG  . ARG B 1 228 ? -9.120  -26.259 33.545 1.00 84.51  ? 260 ARG B CG  1 ? 
ATOM   4033 C CD  . ARG B 1 228 ? -8.800  -25.784 34.970 1.00 94.04  ? 260 ARG B CD  1 ? 
ATOM   4034 N NE  . ARG B 1 228 ? -8.854  -26.806 36.025 1.00 101.96 ? 260 ARG B NE  1 ? 
ATOM   4035 C CZ  . ARG B 1 228 ? -9.949  -27.387 36.528 1.00 108.76 ? 260 ARG B CZ  1 ? 
ATOM   4036 N NH1 . ARG B 1 228 ? -11.153 -27.084 36.072 1.00 119.04 ? 260 ARG B NH1 1 ? 
ATOM   4037 N NH2 . ARG B 1 228 ? -9.835  -28.284 37.495 1.00 110.79 ? 260 ARG B NH2 1 ? 
ATOM   4038 N N   . TYR B 1 229 ? -8.878  -29.712 31.804 1.00 79.80  ? 261 TYR B N   1 ? 
ATOM   4039 C CA  . TYR B 1 229 ? -9.820  -30.801 32.006 1.00 71.84  ? 261 TYR B CA  1 ? 
ATOM   4040 C C   . TYR B 1 229 ? -10.859 -30.326 33.014 1.00 73.27  ? 261 TYR B C   1 ? 
ATOM   4041 O O   . TYR B 1 229 ? -10.489 -29.889 34.102 1.00 77.32  ? 261 TYR B O   1 ? 
ATOM   4042 C CB  . TYR B 1 229 ? -9.108  -32.071 32.484 1.00 77.00  ? 261 TYR B CB  1 ? 
ATOM   4043 C CG  . TYR B 1 229 ? -9.992  -33.311 32.571 1.00 74.22  ? 261 TYR B CG  1 ? 
ATOM   4044 C CD1 . TYR B 1 229 ? -10.336 -34.038 31.434 1.00 72.16  ? 261 TYR B CD1 1 ? 
ATOM   4045 C CD2 . TYR B 1 229 ? -10.474 -33.762 33.792 1.00 75.28  ? 261 TYR B CD2 1 ? 
ATOM   4046 C CE1 . TYR B 1 229 ? -11.143 -35.162 31.508 1.00 70.60  ? 261 TYR B CE1 1 ? 
ATOM   4047 C CE2 . TYR B 1 229 ? -11.284 -34.885 33.881 1.00 73.29  ? 261 TYR B CE2 1 ? 
ATOM   4048 C CZ  . TYR B 1 229 ? -11.615 -35.589 32.737 1.00 71.00  ? 261 TYR B CZ  1 ? 
ATOM   4049 O OH  . TYR B 1 229 ? -12.401 -36.702 32.826 1.00 68.43  ? 261 TYR B OH  1 ? 
ATOM   4050 N N   . PRO B 1 230 ? -12.170 -30.360 32.669 1.00 74.05  ? 262 PRO B N   1 ? 
ATOM   4051 C CA  . PRO B 1 230 ? -13.203 -29.653 33.434 1.00 75.55  ? 262 PRO B CA  1 ? 
ATOM   4052 C C   . PRO B 1 230 ? -13.876 -30.394 34.587 1.00 81.76  ? 262 PRO B C   1 ? 
ATOM   4053 O O   . PRO B 1 230 ? -14.949 -29.983 35.039 1.00 81.38  ? 262 PRO B O   1 ? 
ATOM   4054 C CB  . PRO B 1 230 ? -14.227 -29.316 32.330 1.00 74.52  ? 262 PRO B CB  1 ? 
ATOM   4055 C CG  . PRO B 1 230 ? -14.052 -30.382 31.265 1.00 70.61  ? 262 PRO B CG  1 ? 
ATOM   4056 C CD  . PRO B 1 230 ? -12.721 -31.065 31.503 1.00 71.42  ? 262 PRO B CD  1 ? 
ATOM   4057 N N   . ILE B 1 231 ? -13.238 -31.481 35.043 1.00 82.20  ? 263 ILE B N   1 ? 
ATOM   4058 C CA  . ILE B 1 231 ? -13.711 -32.284 36.163 1.00 86.35  ? 263 ILE B CA  1 ? 
ATOM   4059 C C   . ILE B 1 231 ? -12.517 -32.561 37.072 1.00 94.24  ? 263 ILE B C   1 ? 
ATOM   4060 O O   . ILE B 1 231 ? -11.598 -33.276 36.682 1.00 99.23  ? 263 ILE B O   1 ? 
ATOM   4061 C CB  . ILE B 1 231 ? -14.378 -33.590 35.688 1.00 80.28  ? 263 ILE B CB  1 ? 
ATOM   4062 C CG1 . ILE B 1 231 ? -15.491 -33.324 34.679 1.00 77.35  ? 263 ILE B CG1 1 ? 
ATOM   4063 C CG2 . ILE B 1 231 ? -14.888 -34.397 36.882 1.00 80.28  ? 263 ILE B CG2 1 ? 
ATOM   4064 C CD1 . ILE B 1 231 ? -16.029 -34.577 34.025 1.00 81.83  ? 263 ILE B CD1 1 ? 
ATOM   4065 N N   . PRO B 1 232 ? -12.472 -32.002 38.302 1.00 100.58 ? 264 PRO B N   1 ? 
ATOM   4066 C CA  . PRO B 1 232 ? -13.608 -31.297 38.898 1.00 101.80 ? 264 PRO B CA  1 ? 
ATOM   4067 C C   . PRO B 1 232 ? -13.730 -29.880 38.348 1.00 106.48 ? 264 PRO B C   1 ? 
ATOM   4068 O O   . PRO B 1 232 ? -12.803 -29.390 37.705 1.00 101.22 ? 264 PRO B O   1 ? 
ATOM   4069 C CB  . PRO B 1 232 ? -13.203 -31.304 40.370 1.00 105.83 ? 264 PRO B CB  1 ? 
ATOM   4070 C CG  . PRO B 1 232 ? -11.707 -31.060 40.305 1.00 106.39 ? 264 PRO B CG  1 ? 
ATOM   4071 C CD  . PRO B 1 232 ? -11.262 -31.929 39.138 1.00 103.53 ? 264 PRO B CD  1 ? 
ATOM   4072 N N   . PRO B 1 233 ? -14.852 -29.168 38.597 1.00 113.04 ? 265 PRO B N   1 ? 
ATOM   4073 C CA  . PRO B 1 233 ? -15.046 -27.831 38.034 1.00 115.94 ? 265 PRO B CA  1 ? 
ATOM   4074 C C   . PRO B 1 233 ? -14.125 -26.820 38.711 1.00 114.26 ? 265 PRO B C   1 ? 
ATOM   4075 O O   . PRO B 1 233 ? -13.630 -27.080 39.803 1.00 108.29 ? 265 PRO B O   1 ? 
ATOM   4076 C CB  . PRO B 1 233 ? -16.535 -27.544 38.285 1.00 113.59 ? 265 PRO B CB  1 ? 
ATOM   4077 C CG  . PRO B 1 233 ? -17.118 -28.891 38.661 1.00 115.29 ? 265 PRO B CG  1 ? 
ATOM   4078 C CD  . PRO B 1 233 ? -16.000 -29.603 39.404 1.00 111.75 ? 265 PRO B CD  1 ? 
ATOM   4079 N N   . PRO B 1 234 ? -13.849 -25.652 38.086 1.00 115.10 ? 266 PRO B N   1 ? 
ATOM   4080 C CA  . PRO B 1 234 ? -12.988 -24.638 38.695 1.00 116.19 ? 266 PRO B CA  1 ? 
ATOM   4081 C C   . PRO B 1 234 ? -13.734 -23.849 39.769 1.00 125.72 ? 266 PRO B C   1 ? 
ATOM   4082 O O   . PRO B 1 234 ? -14.938 -23.630 39.648 1.00 106.34 ? 266 PRO B O   1 ? 
ATOM   4083 C CB  . PRO B 1 234 ? -12.554 -23.733 37.522 1.00 114.56 ? 266 PRO B CB  1 ? 
ATOM   4084 C CG  . PRO B 1 234 ? -13.268 -24.280 36.294 1.00 121.79 ? 266 PRO B CG  1 ? 
ATOM   4085 C CD  . PRO B 1 234 ? -14.345 -25.244 36.764 1.00 120.75 ? 266 PRO B CD  1 ? 
ATOM   4086 N N   . ASP B 1 235 ? -12.997 -23.422 40.805 1.00 145.02 ? 267 ASP B N   1 ? 
ATOM   4087 C CA  . ASP B 1 235 ? -13.527 -22.551 41.848 1.00 151.96 ? 267 ASP B CA  1 ? 
ATOM   4088 C C   . ASP B 1 235 ? -13.303 -21.092 41.448 1.00 153.57 ? 267 ASP B C   1 ? 
ATOM   4089 O O   . ASP B 1 235 ? -12.521 -20.807 40.543 1.00 156.08 ? 267 ASP B O   1 ? 
ATOM   4090 C CB  . ASP B 1 235 ? -12.989 -22.913 43.231 1.00 151.26 ? 267 ASP B CB  1 ? 
ATOM   4091 C CG  . ASP B 1 235 ? -11.531 -23.348 43.328 1.00 147.40 ? 267 ASP B CG  1 ? 
ATOM   4092 O OD1 . ASP B 1 235 ? -11.208 -24.436 42.807 1.00 154.78 ? 267 ASP B OD1 1 ? 
ATOM   4093 O OD2 . ASP B 1 235 ? -10.727 -22.608 43.936 1.00 130.44 ? 267 ASP B OD2 1 ? 
ATOM   4094 N N   . ALA B 1 236 ? -14.010 -20.176 42.127 1.00 154.38 ? 268 ALA B N   1 ? 
ATOM   4095 C CA  . ALA B 1 236 ? -13.877 -18.743 41.899 1.00 146.81 ? 268 ALA B CA  1 ? 
ATOM   4096 C C   . ALA B 1 236 ? -12.413 -18.319 42.013 1.00 148.90 ? 268 ALA B C   1 ? 
ATOM   4097 O O   . ALA B 1 236 ? -11.968 -17.420 41.304 1.00 140.03 ? 268 ALA B O   1 ? 
ATOM   4098 C CB  . ALA B 1 236 ? -14.740 -17.981 42.884 1.00 143.40 ? 268 ALA B CB  1 ? 
ATOM   4099 N N   . LYS B 1 237 ? -11.682 -18.985 42.917 1.00 160.13 ? 269 LYS B N   1 ? 
ATOM   4100 C CA  . LYS B 1 237 ? -10.265 -18.738 43.151 1.00 169.63 ? 269 LYS B CA  1 ? 
ATOM   4101 C C   . LYS B 1 237 ? -9.471  -19.041 41.877 1.00 163.46 ? 269 LYS B C   1 ? 
ATOM   4102 O O   . LYS B 1 237 ? -8.407  -18.465 41.660 1.00 161.58 ? 269 LYS B O   1 ? 
ATOM   4103 C CB  . LYS B 1 237 ? -9.821  -19.590 44.352 1.00 175.52 ? 269 LYS B CB  1 ? 
ATOM   4104 C CG  . LYS B 1 237 ? -8.744  -19.051 45.304 1.00 173.48 ? 269 LYS B CG  1 ? 
ATOM   4105 C CD  . LYS B 1 237 ? -7.307  -19.036 44.792 1.00 171.31 ? 269 LYS B CD  1 ? 
ATOM   4106 C CE  . LYS B 1 237 ? -6.694  -17.670 44.670 1.00 165.97 ? 269 LYS B CE  1 ? 
ATOM   4107 N NZ  . LYS B 1 237 ? -7.364  -16.795 43.707 1.00 164.36 ? 269 LYS B NZ  1 ? 
ATOM   4108 N N   . GLU B 1 238 ? -9.998  -19.942 41.034 1.00 155.26 ? 270 GLU B N   1 ? 
ATOM   4109 C CA  . GLU B 1 238 ? -9.326  -20.352 39.810 1.00 149.37 ? 270 GLU B CA  1 ? 
ATOM   4110 C C   . GLU B 1 238 ? -9.921  -19.628 38.599 1.00 140.01 ? 270 GLU B C   1 ? 
ATOM   4111 O O   . GLU B 1 238 ? -9.189  -19.248 37.692 1.00 139.01 ? 270 GLU B O   1 ? 
ATOM   4112 C CB  . GLU B 1 238 ? -9.404  -21.868 39.601 1.00 149.17 ? 270 GLU B CB  1 ? 
ATOM   4113 C CG  . GLU B 1 238 ? -9.281  -22.704 40.876 1.00 152.30 ? 270 GLU B CG  1 ? 
ATOM   4114 C CD  . GLU B 1 238 ? -7.990  -22.592 41.671 1.00 148.83 ? 270 GLU B CD  1 ? 
ATOM   4115 O OE1 . GLU B 1 238 ? -8.046  -22.213 42.862 1.00 139.85 ? 270 GLU B OE1 1 ? 
ATOM   4116 O OE2 . GLU B 1 238 ? -6.926  -22.909 41.100 1.00 145.37 ? 270 GLU B OE2 1 ? 
ATOM   4117 N N   . LEU B 1 239 ? -11.244 -19.428 38.585 1.00 141.76 ? 271 LEU B N   1 ? 
ATOM   4118 C CA  . LEU B 1 239 ? -11.967 -19.101 37.363 1.00 144.55 ? 271 LEU B CA  1 ? 
ATOM   4119 C C   . LEU B 1 239 ? -11.582 -17.719 36.835 1.00 154.24 ? 271 LEU B C   1 ? 
ATOM   4120 O O   . LEU B 1 239 ? -11.175 -17.596 35.682 1.00 162.94 ? 271 LEU B O   1 ? 
ATOM   4121 C CB  . LEU B 1 239 ? -13.473 -19.202 37.611 1.00 144.85 ? 271 LEU B CB  1 ? 
ATOM   4122 C CG  . LEU B 1 239 ? -14.374 -19.321 36.374 1.00 144.64 ? 271 LEU B CG  1 ? 
ATOM   4123 C CD1 . LEU B 1 239 ? -14.514 -18.013 35.609 1.00 147.62 ? 271 LEU B CD1 1 ? 
ATOM   4124 C CD2 . LEU B 1 239 ? -13.895 -20.426 35.443 1.00 138.84 ? 271 LEU B CD2 1 ? 
ATOM   4125 N N   . GLU B 1 240 ? -11.731 -16.681 37.670 1.00 160.08 ? 272 GLU B N   1 ? 
ATOM   4126 C CA  . GLU B 1 240 ? -11.520 -15.302 37.248 1.00 157.27 ? 272 GLU B CA  1 ? 
ATOM   4127 C C   . GLU B 1 240 ? -10.087 -15.117 36.757 1.00 139.37 ? 272 GLU B C   1 ? 
ATOM   4128 O O   . GLU B 1 240 ? -9.794  -14.169 36.032 1.00 134.14 ? 272 GLU B O   1 ? 
ATOM   4129 C CB  . GLU B 1 240 ? -11.670 -14.251 38.351 1.00 167.45 ? 272 GLU B CB  1 ? 
ATOM   4130 C CG  . GLU B 1 240 ? -12.879 -14.424 39.266 1.00 172.79 ? 272 GLU B CG  1 ? 
ATOM   4131 C CD  . GLU B 1 240 ? -12.841 -13.512 40.481 1.00 174.05 ? 272 GLU B CD  1 ? 
ATOM   4132 O OE1 . GLU B 1 240 ? -13.810 -12.748 40.669 1.00 169.56 ? 272 GLU B OE1 1 ? 
ATOM   4133 O OE2 . GLU B 1 240 ? -11.843 -13.558 41.235 1.00 177.12 ? 272 GLU B OE2 1 ? 
ATOM   4134 N N   . LEU B 1 241 ? -9.195  -16.007 37.206 1.00 131.67 ? 273 LEU B N   1 ? 
ATOM   4135 C CA  . LEU B 1 241 ? -7.805  -16.009 36.781 1.00 143.27 ? 273 LEU B CA  1 ? 
ATOM   4136 C C   . LEU B 1 241 ? -7.702  -16.231 35.271 1.00 141.59 ? 273 LEU B C   1 ? 
ATOM   4137 O O   . LEU B 1 241 ? -6.835  -15.650 34.619 1.00 150.58 ? 273 LEU B O   1 ? 
ATOM   4138 C CB  . LEU B 1 241 ? -7.064  -17.076 37.591 1.00 144.31 ? 273 LEU B CB  1 ? 
ATOM   4139 C CG  . LEU B 1 241 ? -5.705  -17.548 37.061 1.00 141.74 ? 273 LEU B CG  1 ? 
ATOM   4140 C CD1 . LEU B 1 241 ? -4.758  -17.794 38.229 1.00 137.37 ? 273 LEU B CD1 1 ? 
ATOM   4141 C CD2 . LEU B 1 241 ? -5.839  -18.809 36.209 1.00 135.74 ? 273 LEU B CD2 1 ? 
ATOM   4142 N N   . MET B 1 242 ? -8.602  -17.058 34.726 1.00 131.21 ? 274 MET B N   1 ? 
ATOM   4143 C CA  . MET B 1 242 ? -8.546  -17.472 33.333 1.00 115.41 ? 274 MET B CA  1 ? 
ATOM   4144 C C   . MET B 1 242 ? -9.122  -16.379 32.425 1.00 113.02 ? 274 MET B C   1 ? 
ATOM   4145 O O   . MET B 1 242 ? -8.393  -15.832 31.597 1.00 124.51 ? 274 MET B O   1 ? 
ATOM   4146 C CB  . MET B 1 242 ? -9.299  -18.794 33.138 1.00 113.16 ? 274 MET B CB  1 ? 
ATOM   4147 C CG  . MET B 1 242 ? -8.881  -19.908 34.089 1.00 109.27 ? 274 MET B CG  1 ? 
ATOM   4148 S SD  . MET B 1 242 ? -9.995  -21.329 34.041 1.00 110.76 ? 274 MET B SD  1 ? 
ATOM   4149 C CE  . MET B 1 242 ? -9.343  -22.375 35.351 1.00 100.91 ? 274 MET B CE  1 ? 
ATOM   4150 N N   . PHE B 1 243 ? -10.416 -16.053 32.587 1.00 93.79  ? 275 PHE B N   1 ? 
ATOM   4151 C CA  . PHE B 1 243 ? -11.146 -15.264 31.600 1.00 101.49 ? 275 PHE B CA  1 ? 
ATOM   4152 C C   . PHE B 1 243 ? -11.251 -13.789 31.983 1.00 117.67 ? 275 PHE B C   1 ? 
ATOM   4153 O O   . PHE B 1 243 ? -11.653 -12.971 31.154 1.00 111.86 ? 275 PHE B O   1 ? 
ATOM   4154 C CB  . PHE B 1 243 ? -12.590 -15.734 31.421 1.00 95.37  ? 275 PHE B CB  1 ? 
ATOM   4155 C CG  . PHE B 1 243 ? -12.732 -17.217 31.122 1.00 90.03  ? 275 PHE B CG  1 ? 
ATOM   4156 C CD1 . PHE B 1 243 ? -12.834 -18.144 32.159 1.00 92.58  ? 275 PHE B CD1 1 ? 
ATOM   4157 C CD2 . PHE B 1 243 ? -12.759 -17.678 29.812 1.00 82.44  ? 275 PHE B CD2 1 ? 
ATOM   4158 C CE1 . PHE B 1 243 ? -12.966 -19.499 31.891 1.00 87.10  ? 275 PHE B CE1 1 ? 
ATOM   4159 C CE2 . PHE B 1 243 ? -12.896 -19.034 29.549 1.00 86.43  ? 275 PHE B CE2 1 ? 
ATOM   4160 C CZ  . PHE B 1 243 ? -12.999 -19.940 30.588 1.00 87.12  ? 275 PHE B CZ  1 ? 
ATOM   4161 N N   . GLY B 1 244 ? -10.941 -13.465 33.245 1.00 133.10 ? 276 GLY B N   1 ? 
ATOM   4162 C CA  . GLY B 1 244 ? -11.065 -12.107 33.749 1.00 137.96 ? 276 GLY B CA  1 ? 
ATOM   4163 C C   . GLY B 1 244 ? -12.333 -11.901 34.581 1.00 150.82 ? 276 GLY B C   1 ? 
ATOM   4164 O O   . GLY B 1 244 ? -12.364 -11.003 35.419 1.00 160.95 ? 276 GLY B O   1 ? 
ATOM   4165 N N   . CYS B 1 245 ? -13.374 -12.720 34.349 1.00 158.63 ? 277 CYS B N   1 ? 
ATOM   4166 C CA  . CYS B 1 245 ? -14.651 -12.563 35.038 1.00 157.34 ? 277 CYS B CA  1 ? 
ATOM   4167 C C   . CYS B 1 245 ? -15.527 -13.826 34.909 1.00 144.73 ? 277 CYS B C   1 ? 
ATOM   4168 O O   . CYS B 1 245 ? -15.137 -14.743 34.148 1.00 123.38 ? 277 CYS B O   1 ? 
ATOM   4169 C CB  . CYS B 1 245 ? -15.426 -11.360 34.507 1.00 162.55 ? 277 CYS B CB  1 ? 
ATOM   4170 S SG  . CYS B 1 245 ? -15.005 -9.797  35.321 1.00 173.49 ? 277 CYS B SG  1 ? 
ATOM   4171 N N   . PRO B 1 275 ? -5.400  -32.500 44.242 1.00 132.85 ? 307 PRO B N   1 ? 
ATOM   4172 C CA  . PRO B 1 275 ? -5.462  -33.428 43.119 1.00 133.83 ? 307 PRO B CA  1 ? 
ATOM   4173 C C   . PRO B 1 275 ? -6.562  -34.468 43.315 1.00 140.29 ? 307 PRO B C   1 ? 
ATOM   4174 O O   . PRO B 1 275 ? -7.194  -34.503 44.368 1.00 143.90 ? 307 PRO B O   1 ? 
ATOM   4175 C CB  . PRO B 1 275 ? -4.062  -34.055 43.086 1.00 128.79 ? 307 PRO B CB  1 ? 
ATOM   4176 C CG  . PRO B 1 275 ? -3.175  -32.955 43.618 1.00 130.71 ? 307 PRO B CG  1 ? 
ATOM   4177 C CD  . PRO B 1 275 ? -4.026  -32.261 44.672 1.00 132.08 ? 307 PRO B CD  1 ? 
ATOM   4178 N N   . MET B 1 276 ? -6.778  -35.304 42.288 1.00 145.86 ? 308 MET B N   1 ? 
ATOM   4179 C CA  . MET B 1 276 ? -7.783  -36.360 42.324 1.00 144.30 ? 308 MET B CA  1 ? 
ATOM   4180 C C   . MET B 1 276 ? -7.229  -37.654 41.728 1.00 141.78 ? 308 MET B C   1 ? 
ATOM   4181 O O   . MET B 1 276 ? -6.572  -37.634 40.689 1.00 138.31 ? 308 MET B O   1 ? 
ATOM   4182 C CB  . MET B 1 276 ? -9.040  -35.982 41.531 1.00 139.45 ? 308 MET B CB  1 ? 
ATOM   4183 C CG  . MET B 1 276 ? -10.182 -35.457 42.373 1.00 135.18 ? 308 MET B CG  1 ? 
ATOM   4184 S SD  . MET B 1 276 ? -11.761 -35.761 41.555 1.00 147.83 ? 308 MET B SD  1 ? 
ATOM   4185 C CE  . MET B 1 276 ? -12.840 -34.652 42.472 1.00 147.94 ? 308 MET B CE  1 ? 
ATOM   4186 N N   . ALA B 1 277 ? -7.542  -38.777 42.391 1.00 137.19 ? 309 ALA B N   1 ? 
ATOM   4187 C CA  . ALA B 1 277 ? -7.141  -40.101 41.944 1.00 122.98 ? 309 ALA B CA  1 ? 
ATOM   4188 C C   . ALA B 1 277 ? -8.214  -40.680 41.027 1.00 119.36 ? 309 ALA B C   1 ? 
ATOM   4189 O O   . ALA B 1 277 ? -9.402  -40.475 41.261 1.00 125.49 ? 309 ALA B O   1 ? 
ATOM   4190 C CB  . ALA B 1 277 ? -6.907  -40.992 43.140 1.00 120.58 ? 309 ALA B CB  1 ? 
ATOM   4191 N N   . ILE B 1 278 ? -7.774  -41.440 40.017 1.00 119.54 ? 310 ILE B N   1 ? 
ATOM   4192 C CA  . ILE B 1 278 ? -8.626  -41.918 38.937 1.00 127.74 ? 310 ILE B CA  1 ? 
ATOM   4193 C C   . ILE B 1 278 ? -9.926  -42.487 39.506 1.00 136.31 ? 310 ILE B C   1 ? 
ATOM   4194 O O   . ILE B 1 278 ? -10.999 -42.205 38.978 1.00 151.48 ? 310 ILE B O   1 ? 
ATOM   4195 C CB  . ILE B 1 278 ? -7.877  -42.943 38.058 1.00 132.13 ? 310 ILE B CB  1 ? 
ATOM   4196 C CG1 . ILE B 1 278 ? -6.687  -42.307 37.308 1.00 135.93 ? 310 ILE B CG1 1 ? 
ATOM   4197 C CG2 . ILE B 1 278 ? -8.825  -43.656 37.089 1.00 127.78 ? 310 ILE B CG2 1 ? 
ATOM   4198 C CD1 . ILE B 1 278 ? -7.069  -41.367 36.178 1.00 136.84 ? 310 ILE B CD1 1 ? 
ATOM   4199 N N   . PHE B 1 279 ? -9.835  -43.278 40.582 1.00 143.36 ? 311 PHE B N   1 ? 
ATOM   4200 C CA  . PHE B 1 279 ? -11.007 -43.943 41.134 1.00 153.38 ? 311 PHE B CA  1 ? 
ATOM   4201 C C   . PHE B 1 279 ? -12.031 -42.909 41.612 1.00 150.32 ? 311 PHE B C   1 ? 
ATOM   4202 O O   . PHE B 1 279 ? -13.231 -43.159 41.528 1.00 158.30 ? 311 PHE B O   1 ? 
ATOM   4203 C CB  . PHE B 1 279 ? -10.610 -44.934 42.236 1.00 158.93 ? 311 PHE B CB  1 ? 
ATOM   4204 C CG  . PHE B 1 279 ? -10.213 -44.314 43.570 1.00 170.77 ? 311 PHE B CG  1 ? 
ATOM   4205 C CD1 . PHE B 1 279 ? -8.923  -43.837 43.784 1.00 174.01 ? 311 PHE B CD1 1 ? 
ATOM   4206 C CD2 . PHE B 1 279 ? -11.129 -44.227 44.614 1.00 175.88 ? 311 PHE B CD2 1 ? 
ATOM   4207 C CE1 . PHE B 1 279 ? -8.567  -43.280 45.004 1.00 173.39 ? 311 PHE B CE1 1 ? 
ATOM   4208 C CE2 . PHE B 1 279 ? -10.767 -43.670 45.831 1.00 173.38 ? 311 PHE B CE2 1 ? 
ATOM   4209 C CZ  . PHE B 1 279 ? -9.488  -43.197 46.023 1.00 176.48 ? 311 PHE B CZ  1 ? 
ATOM   4210 N N   . GLU B 1 280 ? -11.556 -41.754 42.102 1.00 140.81 ? 312 GLU B N   1 ? 
ATOM   4211 C CA  . GLU B 1 280 ? -12.426 -40.671 42.547 1.00 136.15 ? 312 GLU B CA  1 ? 
ATOM   4212 C C   . GLU B 1 280 ? -12.996 -39.930 41.341 1.00 127.45 ? 312 GLU B C   1 ? 
ATOM   4213 O O   . GLU B 1 280 ? -14.161 -39.540 41.332 1.00 119.48 ? 312 GLU B O   1 ? 
ATOM   4214 C CB  . GLU B 1 280 ? -11.685 -39.628 43.384 1.00 137.37 ? 312 GLU B CB  1 ? 
ATOM   4215 C CG  . GLU B 1 280 ? -10.822 -40.218 44.495 1.00 138.53 ? 312 GLU B CG  1 ? 
ATOM   4216 C CD  . GLU B 1 280 ? -10.184 -39.159 45.371 1.00 132.90 ? 312 GLU B CD  1 ? 
ATOM   4217 O OE1 . GLU B 1 280 ? -8.937  -39.104 45.452 1.00 137.12 ? 312 GLU B OE1 1 ? 
ATOM   4218 O OE2 . GLU B 1 280 ? -10.957 -38.384 45.970 1.00 126.12 ? 312 GLU B OE2 1 ? 
ATOM   4219 N N   . LEU B 1 281 ? -12.140 -39.717 40.337 1.00 126.64 ? 313 LEU B N   1 ? 
ATOM   4220 C CA  . LEU B 1 281 ? -12.512 -39.016 39.122 1.00 118.18 ? 313 LEU B CA  1 ? 
ATOM   4221 C C   . LEU B 1 281 ? -13.613 -39.785 38.397 1.00 112.53 ? 313 LEU B C   1 ? 
ATOM   4222 O O   . LEU B 1 281 ? -14.569 -39.179 37.915 1.00 107.80 ? 313 LEU B O   1 ? 
ATOM   4223 C CB  . LEU B 1 281 ? -11.267 -38.841 38.251 1.00 115.58 ? 313 LEU B CB  1 ? 
ATOM   4224 C CG  . LEU B 1 281 ? -11.448 -38.028 36.967 1.00 113.31 ? 313 LEU B CG  1 ? 
ATOM   4225 C CD1 . LEU B 1 281 ? -12.072 -36.678 37.276 1.00 118.62 ? 313 LEU B CD1 1 ? 
ATOM   4226 C CD2 . LEU B 1 281 ? -10.118 -37.858 36.255 1.00 108.77 ? 313 LEU B CD2 1 ? 
ATOM   4227 N N   . LEU B 1 282 ? -13.471 -41.117 38.332 1.00 107.86 ? 314 LEU B N   1 ? 
ATOM   4228 C CA  . LEU B 1 282 ? -14.467 -41.971 37.699 1.00 114.32 ? 314 LEU B CA  1 ? 
ATOM   4229 C C   . LEU B 1 282 ? -15.724 -42.023 38.563 1.00 115.71 ? 314 LEU B C   1 ? 
ATOM   4230 O O   . LEU B 1 282 ? -16.815 -42.235 38.038 1.00 115.43 ? 314 LEU B O   1 ? 
ATOM   4231 C CB  . LEU B 1 282 ? -13.936 -43.376 37.414 1.00 114.83 ? 314 LEU B CB  1 ? 
ATOM   4232 C CG  . LEU B 1 282 ? -12.844 -43.494 36.344 1.00 116.65 ? 314 LEU B CG  1 ? 
ATOM   4233 C CD1 . LEU B 1 282 ? -12.652 -44.950 35.947 1.00 114.74 ? 314 LEU B CD1 1 ? 
ATOM   4234 C CD2 . LEU B 1 282 ? -13.118 -42.647 35.107 1.00 119.77 ? 314 LEU B CD2 1 ? 
ATOM   4235 N N   . ASP B 1 283 ? -15.561 -41.838 39.879 1.00 118.22 ? 315 ASP B N   1 ? 
ATOM   4236 C CA  . ASP B 1 283 ? -16.695 -41.668 40.775 1.00 123.92 ? 315 ASP B CA  1 ? 
ATOM   4237 C C   . ASP B 1 283 ? -17.405 -40.361 40.445 1.00 114.41 ? 315 ASP B C   1 ? 
ATOM   4238 O O   . ASP B 1 283 ? -18.542 -40.384 39.985 1.00 112.75 ? 315 ASP B O   1 ? 
ATOM   4239 C CB  . ASP B 1 283 ? -16.302 -41.757 42.243 1.00 129.65 ? 315 ASP B CB  1 ? 
ATOM   4240 C CG  . ASP B 1 283 ? -16.649 -43.073 42.923 1.00 128.32 ? 315 ASP B CG  1 ? 
ATOM   4241 O OD1 . ASP B 1 283 ? -17.847 -43.270 43.221 1.00 126.63 ? 315 ASP B OD1 1 ? 
ATOM   4242 O OD2 . ASP B 1 283 ? -15.728 -43.895 43.127 1.00 121.34 ? 315 ASP B OD2 1 ? 
ATOM   4243 N N   . TYR B 1 284 ? -16.707 -39.239 40.655 1.00 115.59 ? 316 TYR B N   1 ? 
ATOM   4244 C CA  . TYR B 1 284 ? -17.262 -37.903 40.472 1.00 117.64 ? 316 TYR B CA  1 ? 
ATOM   4245 C C   . TYR B 1 284 ? -18.195 -37.857 39.261 1.00 111.75 ? 316 TYR B C   1 ? 
ATOM   4246 O O   . TYR B 1 284 ? -19.319 -37.370 39.360 1.00 106.15 ? 316 TYR B O   1 ? 
ATOM   4247 C CB  . TYR B 1 284 ? -16.122 -36.891 40.317 1.00 113.38 ? 316 TYR B CB  1 ? 
ATOM   4248 C CG  . TYR B 1 284 ? -16.525 -35.458 40.636 1.00 109.13 ? 316 TYR B CG  1 ? 
ATOM   4249 C CD1 . TYR B 1 284 ? -17.151 -34.662 39.688 1.00 102.21 ? 316 TYR B CD1 1 ? 
ATOM   4250 C CD2 . TYR B 1 284 ? -16.277 -34.903 41.888 1.00 107.61 ? 316 TYR B CD2 1 ? 
ATOM   4251 C CE1 . TYR B 1 284 ? -17.522 -33.358 39.975 1.00 106.41 ? 316 TYR B CE1 1 ? 
ATOM   4252 C CE2 . TYR B 1 284 ? -16.634 -33.597 42.185 1.00 102.81 ? 316 TYR B CE2 1 ? 
ATOM   4253 C CZ  . TYR B 1 284 ? -17.262 -32.824 41.225 1.00 107.76 ? 316 TYR B CZ  1 ? 
ATOM   4254 O OH  . TYR B 1 284 ? -17.625 -31.537 41.505 1.00 121.99 ? 316 TYR B OH  1 ? 
ATOM   4255 N N   . ILE B 1 285 ? -17.723 -38.401 38.132 1.00 105.78 ? 317 ILE B N   1 ? 
ATOM   4256 C CA  . ILE B 1 285 ? -18.445 -38.391 36.868 1.00 102.48 ? 317 ILE B CA  1 ? 
ATOM   4257 C C   . ILE B 1 285 ? -19.829 -39.023 37.021 1.00 108.82 ? 317 ILE B C   1 ? 
ATOM   4258 O O   . ILE B 1 285 ? -20.754 -38.627 36.316 1.00 119.49 ? 317 ILE B O   1 ? 
ATOM   4259 C CB  . ILE B 1 285 ? -17.617 -39.101 35.777 1.00 102.73 ? 317 ILE B CB  1 ? 
ATOM   4260 C CG1 . ILE B 1 285 ? -16.388 -38.268 35.368 1.00 110.67 ? 317 ILE B CG1 1 ? 
ATOM   4261 C CG2 . ILE B 1 285 ? -18.481 -39.459 34.565 1.00 94.30  ? 317 ILE B CG2 1 ? 
ATOM   4262 C CD1 . ILE B 1 285 ? -15.321 -39.041 34.608 1.00 110.95 ? 317 ILE B CD1 1 ? 
ATOM   4263 N N   . VAL B 1 286 ? -19.959 -40.012 37.917 1.00 117.80 ? 318 VAL B N   1 ? 
ATOM   4264 C CA  . VAL B 1 286 ? -21.130 -40.876 37.967 1.00 114.21 ? 318 VAL B CA  1 ? 
ATOM   4265 C C   . VAL B 1 286 ? -22.229 -40.259 38.834 1.00 114.44 ? 318 VAL B C   1 ? 
ATOM   4266 O O   . VAL B 1 286 ? -23.411 -40.452 38.545 1.00 101.04 ? 318 VAL B O   1 ? 
ATOM   4267 C CB  . VAL B 1 286 ? -20.746 -42.286 38.461 1.00 111.53 ? 318 VAL B CB  1 ? 
ATOM   4268 C CG1 . VAL B 1 286 ? -21.966 -43.170 38.704 1.00 111.26 ? 318 VAL B CG1 1 ? 
ATOM   4269 C CG2 . VAL B 1 286 ? -19.778 -42.968 37.501 1.00 112.40 ? 318 VAL B CG2 1 ? 
ATOM   4270 N N   . ASN B 1 287 ? -21.847 -39.510 39.878 1.00 110.50 ? 319 ASN B N   1 ? 
ATOM   4271 C CA  . ASN B 1 287 ? -22.811 -39.073 40.877 1.00 123.49 ? 319 ASN B CA  1 ? 
ATOM   4272 C C   . ASN B 1 287 ? -22.636 -37.593 41.221 1.00 122.33 ? 319 ASN B C   1 ? 
ATOM   4273 O O   . ASN B 1 287 ? -23.002 -37.168 42.316 1.00 124.49 ? 319 ASN B O   1 ? 
ATOM   4274 C CB  . ASN B 1 287 ? -22.741 -39.967 42.112 1.00 134.45 ? 319 ASN B CB  1 ? 
ATOM   4275 C CG  . ASN B 1 287 ? -21.321 -40.212 42.564 1.00 137.05 ? 319 ASN B CG  1 ? 
ATOM   4276 O OD1 . ASN B 1 287 ? -20.882 -41.365 42.602 1.00 133.30 ? 319 ASN B OD1 1 ? 
ATOM   4277 N ND2 . ASN B 1 287 ? -20.587 -39.159 42.900 1.00 143.29 ? 319 ASN B ND2 1 ? 
ATOM   4278 N N   . GLU B 1 288 ? -22.087 -36.805 40.292 1.00 120.90 ? 320 GLU B N   1 ? 
ATOM   4279 C CA  . GLU B 1 288 ? -22.024 -35.362 40.467 1.00 115.31 ? 320 GLU B CA  1 ? 
ATOM   4280 C C   . GLU B 1 288 ? -22.573 -34.718 39.202 1.00 97.49  ? 320 GLU B C   1 ? 
ATOM   4281 O O   . GLU B 1 288 ? -22.590 -35.354 38.154 1.00 95.16  ? 320 GLU B O   1 ? 
ATOM   4282 C CB  . GLU B 1 288 ? -20.610 -34.861 40.770 1.00 118.93 ? 320 GLU B CB  1 ? 
ATOM   4283 C CG  . GLU B 1 288 ? -20.168 -35.050 42.220 1.00 122.18 ? 320 GLU B CG  1 ? 
ATOM   4284 C CD  . GLU B 1 288 ? -20.993 -34.310 43.262 1.00 122.68 ? 320 GLU B CD  1 ? 
ATOM   4285 O OE1 . GLU B 1 288 ? -20.609 -33.193 43.681 1.00 106.98 ? 320 GLU B OE1 1 ? 
ATOM   4286 O OE2 . GLU B 1 288 ? -22.019 -34.883 43.685 1.00 130.76 ? 320 GLU B OE2 1 ? 
ATOM   4287 N N   . PRO B 1 289 ? -23.047 -33.454 39.247 1.00 97.61  ? 321 PRO B N   1 ? 
ATOM   4288 C CA  . PRO B 1 289 ? -23.588 -32.823 38.044 1.00 98.44  ? 321 PRO B CA  1 ? 
ATOM   4289 C C   . PRO B 1 289 ? -22.486 -32.703 36.990 1.00 89.18  ? 321 PRO B C   1 ? 
ATOM   4290 O O   . PRO B 1 289 ? -21.302 -32.636 37.323 1.00 85.97  ? 321 PRO B O   1 ? 
ATOM   4291 C CB  . PRO B 1 289 ? -24.139 -31.462 38.530 1.00 93.91  ? 321 PRO B CB  1 ? 
ATOM   4292 C CG  . PRO B 1 289 ? -23.408 -31.197 39.836 1.00 102.02 ? 321 PRO B CG  1 ? 
ATOM   4293 C CD  . PRO B 1 289 ? -23.050 -32.561 40.419 1.00 100.28 ? 321 PRO B CD  1 ? 
ATOM   4294 N N   . PRO B 1 290 ? -22.835 -32.679 35.685 1.00 85.12  ? 322 PRO B N   1 ? 
ATOM   4295 C CA  . PRO B 1 290 ? -21.828 -32.608 34.627 1.00 82.21  ? 322 PRO B CA  1 ? 
ATOM   4296 C C   . PRO B 1 290 ? -21.121 -31.255 34.620 1.00 78.44  ? 322 PRO B C   1 ? 
ATOM   4297 O O   . PRO B 1 290 ? -21.602 -30.289 35.215 1.00 81.90  ? 322 PRO B O   1 ? 
ATOM   4298 C CB  . PRO B 1 290 ? -22.641 -32.862 33.343 1.00 85.37  ? 322 PRO B CB  1 ? 
ATOM   4299 C CG  . PRO B 1 290 ? -24.040 -32.388 33.682 1.00 86.72  ? 322 PRO B CG  1 ? 
ATOM   4300 C CD  . PRO B 1 290 ? -24.212 -32.666 35.165 1.00 88.46  ? 322 PRO B CD  1 ? 
ATOM   4301 N N   . PRO B 1 291 ? -19.957 -31.133 33.949 1.00 75.57  ? 323 PRO B N   1 ? 
ATOM   4302 C CA  . PRO B 1 291 ? -19.319 -29.827 33.775 1.00 81.55  ? 323 PRO B CA  1 ? 
ATOM   4303 C C   . PRO B 1 291 ? -20.117 -28.942 32.819 1.00 74.62  ? 323 PRO B C   1 ? 
ATOM   4304 O O   . PRO B 1 291 ? -20.946 -29.434 32.052 1.00 67.86  ? 323 PRO B O   1 ? 
ATOM   4305 C CB  . PRO B 1 291 ? -17.925 -30.181 33.235 1.00 81.44  ? 323 PRO B CB  1 ? 
ATOM   4306 C CG  . PRO B 1 291 ? -18.135 -31.492 32.513 1.00 84.26  ? 323 PRO B CG  1 ? 
ATOM   4307 C CD  . PRO B 1 291 ? -19.216 -32.225 33.301 1.00 82.38  ? 323 PRO B CD  1 ? 
ATOM   4308 N N   . LYS B 1 292 ? -19.859 -27.631 32.880 1.00 73.59  ? 324 LYS B N   1 ? 
ATOM   4309 C CA  . LYS B 1 292 ? -20.569 -26.678 32.042 1.00 84.64  ? 324 LYS B CA  1 ? 
ATOM   4310 C C   . LYS B 1 292 ? -19.609 -25.557 31.650 1.00 78.35  ? 324 LYS B C   1 ? 
ATOM   4311 O O   . LYS B 1 292 ? -18.650 -25.286 32.373 1.00 75.98  ? 324 LYS B O   1 ? 
ATOM   4312 C CB  . LYS B 1 292 ? -21.834 -26.165 32.752 1.00 86.57  ? 324 LYS B CB  1 ? 
ATOM   4313 C CG  . LYS B 1 292 ? -21.658 -25.742 34.218 1.00 94.73  ? 324 LYS B CG  1 ? 
ATOM   4314 C CD  . LYS B 1 292 ? -22.883 -25.151 34.919 1.00 104.09 ? 324 LYS B CD  1 ? 
ATOM   4315 C CE  . LYS B 1 292 ? -24.039 -26.095 35.100 1.00 117.43 ? 324 LYS B CE  1 ? 
ATOM   4316 N NZ  . LYS B 1 292 ? -23.778 -27.135 36.100 1.00 120.46 ? 324 LYS B NZ  1 ? 
ATOM   4317 N N   . LEU B 1 293 ? -19.863 -24.945 30.483 1.00 70.56  ? 325 LEU B N   1 ? 
ATOM   4318 C CA  . LEU B 1 293 ? -19.190 -23.714 30.109 1.00 67.75  ? 325 LEU B CA  1 ? 
ATOM   4319 C C   . LEU B 1 293 ? -19.499 -22.687 31.190 1.00 75.36  ? 325 LEU B C   1 ? 
ATOM   4320 O O   . LEU B 1 293 ? -20.548 -22.781 31.822 1.00 82.64  ? 325 LEU B O   1 ? 
ATOM   4321 C CB  . LEU B 1 293 ? -19.631 -23.208 28.735 1.00 63.40  ? 325 LEU B CB  1 ? 
ATOM   4322 C CG  . LEU B 1 293 ? -19.151 -24.022 27.531 1.00 67.05  ? 325 LEU B CG  1 ? 
ATOM   4323 C CD1 . LEU B 1 293 ? -19.597 -23.480 26.179 1.00 68.98  ? 325 LEU B CD1 1 ? 
ATOM   4324 C CD2 . LEU B 1 293 ? -17.645 -24.096 27.570 1.00 70.58  ? 325 LEU B CD2 1 ? 
ATOM   4325 N N   . PRO B 1 294 ? -18.581 -21.732 31.480 1.00 82.91  ? 326 PRO B N   1 ? 
ATOM   4326 C CA  . PRO B 1 294 ? -18.949 -20.499 32.177 1.00 81.63  ? 326 PRO B CA  1 ? 
ATOM   4327 C C   . PRO B 1 294 ? -19.810 -19.585 31.305 1.00 88.48  ? 326 PRO B C   1 ? 
ATOM   4328 O O   . PRO B 1 294 ? -19.771 -19.651 30.076 1.00 85.34  ? 326 PRO B O   1 ? 
ATOM   4329 C CB  . PRO B 1 294 ? -17.603 -19.869 32.557 1.00 79.23  ? 326 PRO B CB  1 ? 
ATOM   4330 C CG  . PRO B 1 294 ? -16.624 -20.437 31.565 1.00 76.97  ? 326 PRO B CG  1 ? 
ATOM   4331 C CD  . PRO B 1 294 ? -17.133 -21.825 31.228 1.00 83.10  ? 326 PRO B CD  1 ? 
ATOM   4332 N N   . SER B 1 295 ? -20.611 -18.743 31.965 1.00 99.92  ? 327 SER B N   1 ? 
ATOM   4333 C CA  . SER B 1 295 ? -21.579 -17.901 31.281 1.00 98.65  ? 327 SER B CA  1 ? 
ATOM   4334 C C   . SER B 1 295 ? -20.886 -16.660 30.732 1.00 86.37  ? 327 SER B C   1 ? 
ATOM   4335 O O   . SER B 1 295 ? -19.718 -16.427 31.026 1.00 95.18  ? 327 SER B O   1 ? 
ATOM   4336 C CB  . SER B 1 295 ? -22.679 -17.535 32.216 1.00 93.33  ? 327 SER B CB  1 ? 
ATOM   4337 O OG  . SER B 1 295 ? -22.102 -17.097 33.436 1.00 97.35  ? 327 SER B OG  1 ? 
ATOM   4338 N N   . GLY B 1 296 ? -21.600 -15.897 29.899 1.00 82.13  ? 328 GLY B N   1 ? 
ATOM   4339 C CA  . GLY B 1 296 ? -21.166 -14.567 29.501 1.00 84.11  ? 328 GLY B CA  1 ? 
ATOM   4340 C C   . GLY B 1 296 ? -19.971 -14.593 28.550 1.00 95.70  ? 328 GLY B C   1 ? 
ATOM   4341 O O   . GLY B 1 296 ? -19.966 -13.868 27.554 1.00 105.43 ? 328 GLY B O   1 ? 
ATOM   4342 N N   . VAL B 1 297 ? -18.952 -15.404 28.873 1.00 84.87  ? 329 VAL B N   1 ? 
ATOM   4343 C CA  . VAL B 1 297 ? -17.790 -15.528 28.009 1.00 81.38  ? 329 VAL B CA  1 ? 
ATOM   4344 C C   . VAL B 1 297 ? -18.225 -16.238 26.732 1.00 71.40  ? 329 VAL B C   1 ? 
ATOM   4345 O O   . VAL B 1 297 ? -17.846 -15.807 25.644 1.00 82.12  ? 329 VAL B O   1 ? 
ATOM   4346 C CB  . VAL B 1 297 ? -16.518 -16.176 28.604 1.00 79.79  ? 329 VAL B CB  1 ? 
ATOM   4347 C CG1 . VAL B 1 297 ? -15.696 -15.156 29.371 1.00 89.53  ? 329 VAL B CG1 1 ? 
ATOM   4348 C CG2 . VAL B 1 297 ? -16.788 -17.383 29.485 1.00 76.66  ? 329 VAL B CG2 1 ? 
ATOM   4349 N N   . PHE B 1 298 ? -19.023 -17.307 26.860 1.00 69.43  ? 330 PHE B N   1 ? 
ATOM   4350 C CA  . PHE B 1 298 ? -19.442 -18.069 25.690 1.00 65.08  ? 330 PHE B CA  1 ? 
ATOM   4351 C C   . PHE B 1 298 ? -20.894 -17.743 25.368 1.00 61.55  ? 330 PHE B C   1 ? 
ATOM   4352 O O   . PHE B 1 298 ? -21.675 -17.426 26.255 1.00 68.09  ? 330 PHE B O   1 ? 
ATOM   4353 C CB  . PHE B 1 298 ? -19.190 -19.567 25.872 1.00 58.55  ? 330 PHE B CB  1 ? 
ATOM   4354 C CG  . PHE B 1 298 ? -17.723 -19.837 26.182 1.00 66.52  ? 330 PHE B CG  1 ? 
ATOM   4355 C CD1 . PHE B 1 298 ? -16.768 -19.836 25.172 1.00 61.43  ? 330 PHE B CD1 1 ? 
ATOM   4356 C CD2 . PHE B 1 298 ? -17.293 -20.046 27.487 1.00 66.44  ? 330 PHE B CD2 1 ? 
ATOM   4357 C CE1 . PHE B 1 298 ? -15.433 -20.047 25.463 1.00 57.10  ? 330 PHE B CE1 1 ? 
ATOM   4358 C CE2 . PHE B 1 298 ? -15.953 -20.260 27.765 1.00 65.30  ? 330 PHE B CE2 1 ? 
ATOM   4359 C CZ  . PHE B 1 298 ? -15.028 -20.259 26.753 1.00 58.87  ? 330 PHE B CZ  1 ? 
ATOM   4360 N N   . SER B 1 299 ? -21.232 -17.856 24.082 1.00 55.22  ? 331 SER B N   1 ? 
ATOM   4361 C CA  . SER B 1 299 ? -22.566 -17.567 23.597 1.00 52.75  ? 331 SER B CA  1 ? 
ATOM   4362 C C   . SER B 1 299 ? -23.570 -18.549 24.187 1.00 63.54  ? 331 SER B C   1 ? 
ATOM   4363 O O   . SER B 1 299 ? -23.217 -19.652 24.612 1.00 55.87  ? 331 SER B O   1 ? 
ATOM   4364 C CB  . SER B 1 299 ? -22.616 -17.655 22.096 1.00 48.75  ? 331 SER B CB  1 ? 
ATOM   4365 O OG  . SER B 1 299 ? -22.775 -19.014 21.716 1.00 43.53  ? 331 SER B OG  1 ? 
ATOM   4366 N N   . LEU B 1 300 ? -24.848 -18.168 24.114 1.00 65.10  ? 332 LEU B N   1 ? 
ATOM   4367 C CA  . LEU B 1 300 ? -25.891 -18.979 24.709 1.00 62.34  ? 332 LEU B CA  1 ? 
ATOM   4368 C C   . LEU B 1 300 ? -25.953 -20.312 23.960 1.00 57.48  ? 332 LEU B C   1 ? 
ATOM   4369 O O   . LEU B 1 300 ? -25.940 -21.394 24.549 1.00 56.41  ? 332 LEU B O   1 ? 
ATOM   4370 C CB  . LEU B 1 300 ? -27.191 -18.186 24.613 1.00 64.14  ? 332 LEU B CB  1 ? 
ATOM   4371 C CG  . LEU B 1 300 ? -28.032 -18.099 25.887 1.00 69.15  ? 332 LEU B CG  1 ? 
ATOM   4372 C CD1 . LEU B 1 300 ? -29.446 -17.687 25.474 1.00 73.41  ? 332 LEU B CD1 1 ? 
ATOM   4373 C CD2 . LEU B 1 300 ? -28.053 -19.364 26.708 1.00 73.27  ? 332 LEU B CD2 1 ? 
ATOM   4374 N N   . GLU B 1 301 ? -25.958 -20.215 22.632 1.00 53.45  ? 333 GLU B N   1 ? 
ATOM   4375 C CA  . GLU B 1 301 ? -26.020 -21.385 21.779 1.00 58.64  ? 333 GLU B CA  1 ? 
ATOM   4376 C C   . GLU B 1 301 ? -24.889 -22.356 22.120 1.00 62.84  ? 333 GLU B C   1 ? 
ATOM   4377 O O   . GLU B 1 301 ? -25.136 -23.540 22.277 1.00 61.67  ? 333 GLU B O   1 ? 
ATOM   4378 C CB  . GLU B 1 301 ? -25.904 -20.983 20.311 1.00 63.67  ? 333 GLU B CB  1 ? 
ATOM   4379 C CG  . GLU B 1 301 ? -26.504 -19.618 20.015 1.00 69.63  ? 333 GLU B CG  1 ? 
ATOM   4380 C CD  . GLU B 1 301 ? -26.882 -19.489 18.561 1.00 88.47  ? 333 GLU B CD  1 ? 
ATOM   4381 O OE1 . GLU B 1 301 ? -26.008 -19.851 17.745 1.00 87.53  ? 333 GLU B OE1 1 ? 
ATOM   4382 O OE2 . GLU B 1 301 ? -28.022 -19.063 18.253 1.00 98.31  ? 333 GLU B OE2 1 ? 
ATOM   4383 N N   . PHE B 1 302 ? -23.636 -21.882 22.216 1.00 70.21  ? 334 PHE B N   1 ? 
ATOM   4384 C CA  . PHE B 1 302 ? -22.527 -22.796 22.466 1.00 62.94  ? 334 PHE B CA  1 ? 
ATOM   4385 C C   . PHE B 1 302 ? -22.745 -23.455 23.830 1.00 56.29  ? 334 PHE B C   1 ? 
ATOM   4386 O O   . PHE B 1 302 ? -22.566 -24.664 23.957 1.00 52.45  ? 334 PHE B O   1 ? 
ATOM   4387 C CB  . PHE B 1 302 ? -21.139 -22.144 22.358 1.00 66.19  ? 334 PHE B CB  1 ? 
ATOM   4388 C CG  . PHE B 1 302 ? -19.919 -23.047 22.557 1.00 66.58  ? 334 PHE B CG  1 ? 
ATOM   4389 C CD1 . PHE B 1 302 ? -19.914 -24.375 22.126 1.00 67.56  ? 334 PHE B CD1 1 ? 
ATOM   4390 C CD2 . PHE B 1 302 ? -18.757 -22.549 23.142 1.00 62.69  ? 334 PHE B CD2 1 ? 
ATOM   4391 C CE1 . PHE B 1 302 ? -18.801 -25.184 22.307 1.00 66.04  ? 334 PHE B CE1 1 ? 
ATOM   4392 C CE2 . PHE B 1 302 ? -17.638 -23.355 23.306 1.00 63.84  ? 334 PHE B CE2 1 ? 
ATOM   4393 C CZ  . PHE B 1 302 ? -17.662 -24.671 22.891 1.00 68.04  ? 334 PHE B CZ  1 ? 
ATOM   4394 N N   . GLN B 1 303 ? -23.162 -22.671 24.836 1.00 57.28  ? 335 GLN B N   1 ? 
ATOM   4395 C CA  . GLN B 1 303 ? -23.392 -23.206 26.172 1.00 65.49  ? 335 GLN B CA  1 ? 
ATOM   4396 C C   . GLN B 1 303 ? -24.458 -24.292 26.124 1.00 67.87  ? 335 GLN B C   1 ? 
ATOM   4397 O O   . GLN B 1 303 ? -24.362 -25.297 26.821 1.00 72.07  ? 335 GLN B O   1 ? 
ATOM   4398 C CB  . GLN B 1 303 ? -23.900 -22.189 27.191 1.00 67.19  ? 335 GLN B CB  1 ? 
ATOM   4399 C CG  . GLN B 1 303 ? -22.922 -21.055 27.452 1.00 76.22  ? 335 GLN B CG  1 ? 
ATOM   4400 C CD  . GLN B 1 303 ? -23.553 -19.916 28.217 1.00 83.73  ? 335 GLN B CD  1 ? 
ATOM   4401 O OE1 . GLN B 1 303 ? -23.686 -18.793 27.712 1.00 83.59  ? 335 GLN B OE1 1 ? 
ATOM   4402 N NE2 . GLN B 1 303 ? -23.963 -20.212 29.444 1.00 73.30  ? 335 GLN B NE2 1 ? 
ATOM   4403 N N   . ASP B 1 304 ? -25.490 -24.074 25.313 1.00 69.07  ? 336 ASP B N   1 ? 
ATOM   4404 C CA  . ASP B 1 304 ? -26.572 -25.033 25.282 1.00 65.18  ? 336 ASP B CA  1 ? 
ATOM   4405 C C   . ASP B 1 304 ? -26.067 -26.328 24.671 1.00 57.16  ? 336 ASP B C   1 ? 
ATOM   4406 O O   . ASP B 1 304 ? -26.367 -27.405 25.174 1.00 66.40  ? 336 ASP B O   1 ? 
ATOM   4407 C CB  . ASP B 1 304 ? -27.784 -24.551 24.505 1.00 69.95  ? 336 ASP B CB  1 ? 
ATOM   4408 C CG  . ASP B 1 304 ? -28.963 -25.504 24.634 1.00 79.82  ? 336 ASP B CG  1 ? 
ATOM   4409 O OD1 . ASP B 1 304 ? -29.498 -25.574 25.769 1.00 70.04  ? 336 ASP B OD1 1 ? 
ATOM   4410 O OD2 . ASP B 1 304 ? -29.272 -26.222 23.636 1.00 74.54  ? 336 ASP B OD2 1 ? 
ATOM   4411 N N   . PHE B 1 305 ? -25.339 -26.203 23.559 1.00 59.47  ? 337 PHE B N   1 ? 
ATOM   4412 C CA  . PHE B 1 305 ? -24.849 -27.351 22.808 1.00 66.81  ? 337 PHE B CA  1 ? 
ATOM   4413 C C   . PHE B 1 305 ? -24.104 -28.337 23.708 1.00 68.16  ? 337 PHE B C   1 ? 
ATOM   4414 O O   . PHE B 1 305 ? -24.302 -29.549 23.606 1.00 67.40  ? 337 PHE B O   1 ? 
ATOM   4415 C CB  . PHE B 1 305 ? -23.922 -26.838 21.707 1.00 69.62  ? 337 PHE B CB  1 ? 
ATOM   4416 C CG  . PHE B 1 305 ? -23.384 -27.902 20.763 1.00 70.28  ? 337 PHE B CG  1 ? 
ATOM   4417 C CD1 . PHE B 1 305 ? -24.114 -28.293 19.649 1.00 62.92  ? 337 PHE B CD1 1 ? 
ATOM   4418 C CD2 . PHE B 1 305 ? -22.134 -28.477 20.972 1.00 64.33  ? 337 PHE B CD2 1 ? 
ATOM   4419 C CE1 . PHE B 1 305 ? -23.614 -29.242 18.774 1.00 66.48  ? 337 PHE B CE1 1 ? 
ATOM   4420 C CE2 . PHE B 1 305 ? -21.645 -29.429 20.097 1.00 65.87  ? 337 PHE B CE2 1 ? 
ATOM   4421 C CZ  . PHE B 1 305 ? -22.383 -29.810 18.999 1.00 65.04  ? 337 PHE B CZ  1 ? 
ATOM   4422 N N   . VAL B 1 306 ? -23.227 -27.825 24.577 1.00 65.39  ? 338 VAL B N   1 ? 
ATOM   4423 C CA  . VAL B 1 306 ? -22.396 -28.713 25.375 1.00 70.08  ? 338 VAL B CA  1 ? 
ATOM   4424 C C   . VAL B 1 306 ? -23.263 -29.335 26.460 1.00 63.28  ? 338 VAL B C   1 ? 
ATOM   4425 O O   . VAL B 1 306 ? -23.034 -30.477 26.846 1.00 78.38  ? 338 VAL B O   1 ? 
ATOM   4426 C CB  . VAL B 1 306 ? -21.124 -28.082 25.980 1.00 66.64  ? 338 VAL B CB  1 ? 
ATOM   4427 C CG1 . VAL B 1 306 ? -20.283 -27.391 24.916 1.00 72.10  ? 338 VAL B CG1 1 ? 
ATOM   4428 C CG2 . VAL B 1 306 ? -21.428 -27.125 27.116 1.00 74.19  ? 338 VAL B CG2 1 ? 
ATOM   4429 N N   . ASN B 1 307 ? -24.243 -28.570 26.952 1.00 69.19  ? 339 ASN B N   1 ? 
ATOM   4430 C CA  . ASN B 1 307 ? -25.227 -29.069 27.904 1.00 66.11  ? 339 ASN B CA  1 ? 
ATOM   4431 C C   . ASN B 1 307 ? -26.001 -30.250 27.331 1.00 63.86  ? 339 ASN B C   1 ? 
ATOM   4432 O O   . ASN B 1 307 ? -26.262 -31.205 28.048 1.00 67.68  ? 339 ASN B O   1 ? 
ATOM   4433 C CB  . ASN B 1 307 ? -26.152 -27.953 28.362 1.00 61.32  ? 339 ASN B CB  1 ? 
ATOM   4434 C CG  . ASN B 1 307 ? -25.434 -27.045 29.325 1.00 60.87  ? 339 ASN B CG  1 ? 
ATOM   4435 O OD1 . ASN B 1 307 ? -24.335 -27.379 29.787 1.00 66.78  ? 339 ASN B OD1 1 ? 
ATOM   4436 N ND2 . ASN B 1 307 ? -26.004 -25.881 29.592 1.00 61.49  ? 339 ASN B ND2 1 ? 
ATOM   4437 N N   . LYS B 1 308 ? -26.309 -30.198 26.033 1.00 65.88  ? 340 LYS B N   1 ? 
ATOM   4438 C CA  . LYS B 1 308 ? -27.008 -31.279 25.354 1.00 71.98  ? 340 LYS B CA  1 ? 
ATOM   4439 C C   . LYS B 1 308 ? -26.122 -32.517 25.219 1.00 72.49  ? 340 LYS B C   1 ? 
ATOM   4440 O O   . LYS B 1 308 ? -26.638 -33.625 25.120 1.00 81.15  ? 340 LYS B O   1 ? 
ATOM   4441 C CB  . LYS B 1 308 ? -27.475 -30.835 23.958 1.00 78.79  ? 340 LYS B CB  1 ? 
ATOM   4442 C CG  . LYS B 1 308 ? -28.616 -29.816 23.930 1.00 79.22  ? 340 LYS B CG  1 ? 
ATOM   4443 C CD  . LYS B 1 308 ? -29.987 -30.394 24.261 1.00 87.96  ? 340 LYS B CD  1 ? 
ATOM   4444 C CE  . LYS B 1 308 ? -31.110 -29.399 24.210 1.00 94.91  ? 340 LYS B CE  1 ? 
ATOM   4445 N NZ  . LYS B 1 308 ? -31.200 -28.621 25.448 1.00 99.67  ? 340 LYS B NZ  1 ? 
ATOM   4446 N N   . CYS B 1 309 ? -24.798 -32.317 25.140 1.00 76.50  ? 341 CYS B N   1 ? 
ATOM   4447 C CA  . CYS B 1 309 ? -23.846 -33.404 24.983 1.00 63.25  ? 341 CYS B CA  1 ? 
ATOM   4448 C C   . CYS B 1 309 ? -23.593 -34.090 26.324 1.00 66.06  ? 341 CYS B C   1 ? 
ATOM   4449 O O   . CYS B 1 309 ? -23.302 -35.278 26.349 1.00 74.03  ? 341 CYS B O   1 ? 
ATOM   4450 C CB  . CYS B 1 309 ? -22.522 -32.887 24.442 1.00 62.33  ? 341 CYS B CB  1 ? 
ATOM   4451 S SG  . CYS B 1 309 ? -22.587 -32.330 22.720 1.00 66.91  ? 341 CYS B SG  1 ? 
ATOM   4452 N N   . LEU B 1 310 ? -23.732 -33.339 27.426 1.00 65.82  ? 342 LEU B N   1 ? 
ATOM   4453 C CA  . LEU B 1 310 ? -23.214 -33.735 28.731 1.00 72.38  ? 342 LEU B CA  1 ? 
ATOM   4454 C C   . LEU B 1 310 ? -24.322 -34.126 29.707 1.00 86.04  ? 342 LEU B C   1 ? 
ATOM   4455 O O   . LEU B 1 310 ? -24.112 -34.103 30.921 1.00 85.43  ? 342 LEU B O   1 ? 
ATOM   4456 C CB  . LEU B 1 310 ? -22.407 -32.570 29.304 1.00 68.93  ? 342 LEU B CB  1 ? 
ATOM   4457 C CG  . LEU B 1 310 ? -20.975 -32.410 28.782 1.00 69.13  ? 342 LEU B CG  1 ? 
ATOM   4458 C CD1 . LEU B 1 310 ? -20.333 -31.262 29.531 1.00 70.73  ? 342 LEU B CD1 1 ? 
ATOM   4459 C CD2 . LEU B 1 310 ? -20.150 -33.681 28.938 1.00 69.73  ? 342 LEU B CD2 1 ? 
ATOM   4460 N N   . ILE B 1 311 ? -25.502 -34.459 29.176 1.00 90.21  ? 343 ILE B N   1 ? 
ATOM   4461 C CA  . ILE B 1 311 ? -26.566 -35.048 29.970 1.00 84.93  ? 343 ILE B CA  1 ? 
ATOM   4462 C C   . ILE B 1 311 ? -26.135 -36.467 30.351 1.00 75.97  ? 343 ILE B C   1 ? 
ATOM   4463 O O   . ILE B 1 311 ? -25.797 -37.286 29.494 1.00 64.12  ? 343 ILE B O   1 ? 
ATOM   4464 C CB  . ILE B 1 311 ? -27.904 -35.010 29.200 1.00 86.99  ? 343 ILE B CB  1 ? 
ATOM   4465 C CG1 . ILE B 1 311 ? -28.420 -33.568 29.003 1.00 83.28  ? 343 ILE B CG1 1 ? 
ATOM   4466 C CG2 . ILE B 1 311 ? -28.955 -35.883 29.885 1.00 87.98  ? 343 ILE B CG2 1 ? 
ATOM   4467 C CD1 . ILE B 1 311 ? -29.191 -33.332 27.711 1.00 75.81  ? 343 ILE B CD1 1 ? 
ATOM   4468 N N   . LYS B 1 312 ? -26.170 -36.735 31.658 1.00 79.98  ? 344 LYS B N   1 ? 
ATOM   4469 C CA  . LYS B 1 312 ? -25.734 -37.995 32.243 1.00 86.51  ? 344 LYS B CA  1 ? 
ATOM   4470 C C   . LYS B 1 312 ? -26.462 -39.181 31.606 1.00 84.56  ? 344 LYS B C   1 ? 
ATOM   4471 O O   . LYS B 1 312 ? -25.813 -40.117 31.151 1.00 99.28  ? 344 LYS B O   1 ? 
ATOM   4472 C CB  . LYS B 1 312 ? -26.015 -37.959 33.749 1.00 89.72  ? 344 LYS B CB  1 ? 
ATOM   4473 C CG  . LYS B 1 312 ? -25.602 -36.686 34.484 1.00 93.44  ? 344 LYS B CG  1 ? 
ATOM   4474 C CD  . LYS B 1 312 ? -24.251 -36.749 35.178 1.00 101.70 ? 344 LYS B CD  1 ? 
ATOM   4475 C CE  . LYS B 1 312 ? -24.284 -37.698 36.333 1.00 108.30 ? 344 LYS B CE  1 ? 
ATOM   4476 N NZ  . LYS B 1 312 ? -23.173 -37.478 37.261 1.00 111.99 ? 344 LYS B NZ  1 ? 
ATOM   4477 N N   . ASN B 1 313 ? -27.801 -39.123 31.553 1.00 89.09  ? 345 ASN B N   1 ? 
ATOM   4478 C CA  . ASN B 1 313 ? -28.618 -40.210 31.025 1.00 104.17 ? 345 ASN B CA  1 ? 
ATOM   4479 C C   . ASN B 1 313 ? -28.506 -40.278 29.501 1.00 93.60  ? 345 ASN B C   1 ? 
ATOM   4480 O O   . ASN B 1 313 ? -29.018 -39.401 28.815 1.00 86.55  ? 345 ASN B O   1 ? 
ATOM   4481 C CB  . ASN B 1 313 ? -30.090 -40.069 31.417 1.00 113.79 ? 345 ASN B CB  1 ? 
ATOM   4482 C CG  . ASN B 1 313 ? -30.948 -41.194 30.874 1.00 117.49 ? 345 ASN B CG  1 ? 
ATOM   4483 O OD1 . ASN B 1 313 ? -31.931 -40.951 30.160 1.00 101.47 ? 345 ASN B OD1 1 ? 
ATOM   4484 N ND2 . ASN B 1 313 ? -30.601 -42.431 31.201 1.00 122.19 ? 345 ASN B ND2 1 ? 
ATOM   4485 N N   . PRO B 1 314 ? -27.907 -41.345 28.918 1.00 99.33  ? 346 PRO B N   1 ? 
ATOM   4486 C CA  . PRO B 1 314 ? -27.735 -41.437 27.463 1.00 102.25 ? 346 PRO B CA  1 ? 
ATOM   4487 C C   . PRO B 1 314 ? -28.988 -41.336 26.597 1.00 95.69  ? 346 PRO B C   1 ? 
ATOM   4488 O O   . PRO B 1 314 ? -28.889 -40.958 25.433 1.00 95.14  ? 346 PRO B O   1 ? 
ATOM   4489 C CB  . PRO B 1 314 ? -27.034 -42.799 27.240 1.00 104.96 ? 346 PRO B CB  1 ? 
ATOM   4490 C CG  . PRO B 1 314 ? -27.224 -43.556 28.536 1.00 105.72 ? 346 PRO B CG  1 ? 
ATOM   4491 C CD  . PRO B 1 314 ? -27.338 -42.505 29.626 1.00 100.91 ? 346 PRO B CD  1 ? 
ATOM   4492 N N   . ALA B 1 315 ? -30.147 -41.719 27.144 1.00 106.43 ? 347 ALA B N   1 ? 
ATOM   4493 C CA  . ALA B 1 315 ? -31.392 -41.682 26.388 1.00 115.92 ? 347 ALA B CA  1 ? 
ATOM   4494 C C   . ALA B 1 315 ? -31.890 -40.241 26.269 1.00 113.60 ? 347 ALA B C   1 ? 
ATOM   4495 O O   . ALA B 1 315 ? -32.527 -39.880 25.278 1.00 98.12  ? 347 ALA B O   1 ? 
ATOM   4496 C CB  . ALA B 1 315 ? -32.424 -42.578 27.040 1.00 115.86 ? 347 ALA B CB  1 ? 
ATOM   4497 N N   . GLU B 1 316 ? -31.554 -39.433 27.286 1.00 109.81 ? 348 GLU B N   1 ? 
ATOM   4498 C CA  . GLU B 1 316 ? -31.993 -38.052 27.420 1.00 109.00 ? 348 GLU B CA  1 ? 
ATOM   4499 C C   . GLU B 1 316 ? -30.941 -37.067 26.896 1.00 110.88 ? 348 GLU B C   1 ? 
ATOM   4500 O O   . GLU B 1 316 ? -31.199 -35.866 26.868 1.00 120.95 ? 348 GLU B O   1 ? 
ATOM   4501 C CB  . GLU B 1 316 ? -32.267 -37.886 28.915 1.00 110.46 ? 348 GLU B CB  1 ? 
ATOM   4502 C CG  . GLU B 1 316 ? -33.156 -36.705 29.284 1.00 118.73 ? 348 GLU B CG  1 ? 
ATOM   4503 C CD  . GLU B 1 316 ? -33.814 -36.913 30.639 1.00 125.19 ? 348 GLU B CD  1 ? 
ATOM   4504 O OE1 . GLU B 1 316 ? -33.517 -36.153 31.587 1.00 122.98 ? 348 GLU B OE1 1 ? 
ATOM   4505 O OE2 . GLU B 1 316 ? -34.628 -37.858 30.741 1.00 126.22 ? 348 GLU B OE2 1 ? 
ATOM   4506 N N   . ARG B 1 317 ? -29.759 -37.573 26.503 1.00 97.60  ? 349 ARG B N   1 ? 
ATOM   4507 C CA  . ARG B 1 317 ? -28.704 -36.784 25.878 1.00 87.25  ? 349 ARG B CA  1 ? 
ATOM   4508 C C   . ARG B 1 317 ? -28.928 -36.757 24.368 1.00 74.21  ? 349 ARG B C   1 ? 
ATOM   4509 O O   . ARG B 1 317 ? -29.478 -37.691 23.798 1.00 81.05  ? 349 ARG B O   1 ? 
ATOM   4510 C CB  . ARG B 1 317 ? -27.337 -37.390 26.234 1.00 91.33  ? 349 ARG B CB  1 ? 
ATOM   4511 C CG  . ARG B 1 317 ? -26.122 -36.939 25.428 1.00 92.73  ? 349 ARG B CG  1 ? 
ATOM   4512 C CD  . ARG B 1 317 ? -24.892 -37.821 25.667 1.00 85.07  ? 349 ARG B CD  1 ? 
ATOM   4513 N NE  . ARG B 1 317 ? -24.730 -38.102 27.099 1.00 79.55  ? 349 ARG B NE  1 ? 
ATOM   4514 C CZ  . ARG B 1 317 ? -24.415 -39.279 27.621 1.00 76.75  ? 349 ARG B CZ  1 ? 
ATOM   4515 N NH1 . ARG B 1 317 ? -23.996 -40.251 26.828 1.00 67.42  ? 349 ARG B NH1 1 ? 
ATOM   4516 N NH2 . ARG B 1 317 ? -24.471 -39.456 28.937 1.00 69.65  ? 349 ARG B NH2 1 ? 
ATOM   4517 N N   . ALA B 1 318 ? -28.467 -35.687 23.717 1.00 69.55  ? 350 ALA B N   1 ? 
ATOM   4518 C CA  . ALA B 1 318 ? -28.726 -35.481 22.303 1.00 68.55  ? 350 ALA B CA  1 ? 
ATOM   4519 C C   . ALA B 1 318 ? -27.952 -36.497 21.471 1.00 75.19  ? 350 ALA B C   1 ? 
ATOM   4520 O O   . ALA B 1 318 ? -27.012 -37.111 21.965 1.00 89.86  ? 350 ALA B O   1 ? 
ATOM   4521 C CB  . ALA B 1 318 ? -28.345 -34.079 21.913 1.00 69.13  ? 350 ALA B CB  1 ? 
ATOM   4522 N N   . ASP B 1 319 ? -28.348 -36.634 20.203 1.00 71.79  ? 351 ASP B N   1 ? 
ATOM   4523 C CA  . ASP B 1 319 ? -27.726 -37.565 19.277 1.00 74.37  ? 351 ASP B CA  1 ? 
ATOM   4524 C C   . ASP B 1 319 ? -27.364 -36.809 18.005 1.00 68.87  ? 351 ASP B C   1 ? 
ATOM   4525 O O   . ASP B 1 319 ? -27.699 -35.641 17.857 1.00 84.05  ? 351 ASP B O   1 ? 
ATOM   4526 C CB  . ASP B 1 319 ? -28.631 -38.756 19.010 1.00 88.03  ? 351 ASP B CB  1 ? 
ATOM   4527 C CG  . ASP B 1 319 ? -29.947 -38.433 18.317 1.00 92.48  ? 351 ASP B CG  1 ? 
ATOM   4528 O OD1 . ASP B 1 319 ? -29.932 -38.290 17.073 1.00 91.44  ? 351 ASP B OD1 1 ? 
ATOM   4529 O OD2 . ASP B 1 319 ? -30.970 -38.308 19.032 1.00 89.56  ? 351 ASP B OD2 1 ? 
ATOM   4530 N N   . LEU B 1 320 ? -26.702 -37.493 17.076 1.00 69.16  ? 352 LEU B N   1 ? 
ATOM   4531 C CA  . LEU B 1 320 ? -26.027 -36.828 15.976 1.00 77.58  ? 352 LEU B CA  1 ? 
ATOM   4532 C C   . LEU B 1 320 ? -26.994 -35.961 15.168 1.00 86.21  ? 352 LEU B C   1 ? 
ATOM   4533 O O   . LEU B 1 320 ? -26.583 -34.928 14.629 1.00 81.79  ? 352 LEU B O   1 ? 
ATOM   4534 C CB  . LEU B 1 320 ? -25.315 -37.871 15.112 1.00 83.18  ? 352 LEU B CB  1 ? 
ATOM   4535 C CG  . LEU B 1 320 ? -24.272 -38.747 15.823 1.00 91.80  ? 352 LEU B CG  1 ? 
ATOM   4536 C CD1 . LEU B 1 320 ? -23.477 -39.590 14.821 1.00 89.45  ? 352 LEU B CD1 1 ? 
ATOM   4537 C CD2 . LEU B 1 320 ? -23.326 -37.916 16.695 1.00 94.90  ? 352 LEU B CD2 1 ? 
ATOM   4538 N N   . LYS B 1 321 ? -28.269 -36.371 15.098 1.00 88.65  ? 353 LYS B N   1 ? 
ATOM   4539 C CA  . LYS B 1 321 ? -29.254 -35.653 14.301 1.00 96.93  ? 353 LYS B CA  1 ? 
ATOM   4540 C C   . LYS B 1 321 ? -29.774 -34.429 15.058 1.00 83.09  ? 353 LYS B C   1 ? 
ATOM   4541 O O   . LYS B 1 321 ? -30.001 -33.389 14.442 1.00 79.78  ? 353 LYS B O   1 ? 
ATOM   4542 C CB  . LYS B 1 321 ? -30.340 -36.618 13.803 1.00 108.29 ? 353 LYS B CB  1 ? 
ATOM   4543 C CG  . LYS B 1 321 ? -30.183 -37.184 12.377 1.00 114.32 ? 353 LYS B CG  1 ? 
ATOM   4544 C CD  . LYS B 1 321 ? -28.792 -37.225 11.746 1.00 125.16 ? 353 LYS B CD  1 ? 
ATOM   4545 C CE  . LYS B 1 321 ? -28.549 -36.198 10.671 1.00 129.18 ? 353 LYS B CE  1 ? 
ATOM   4546 N NZ  . LYS B 1 321 ? -28.870 -34.815 11.038 1.00 135.95 ? 353 LYS B NZ  1 ? 
ATOM   4547 N N   . GLN B 1 322 ? -29.953 -34.559 16.380 1.00 76.44  ? 354 GLN B N   1 ? 
ATOM   4548 C CA  . GLN B 1 322 ? -30.326 -33.444 17.240 1.00 79.69  ? 354 GLN B CA  1 ? 
ATOM   4549 C C   . GLN B 1 322 ? -29.206 -32.400 17.262 1.00 87.96  ? 354 GLN B C   1 ? 
ATOM   4550 O O   . GLN B 1 322 ? -29.487 -31.204 17.327 1.00 100.44 ? 354 GLN B O   1 ? 
ATOM   4551 C CB  . GLN B 1 322 ? -30.622 -33.859 18.685 1.00 74.69  ? 354 GLN B CB  1 ? 
ATOM   4552 C CG  . GLN B 1 322 ? -31.698 -34.931 18.849 1.00 82.95  ? 354 GLN B CG  1 ? 
ATOM   4553 C CD  . GLN B 1 322 ? -32.059 -35.228 20.295 1.00 94.84  ? 354 GLN B CD  1 ? 
ATOM   4554 O OE1 . GLN B 1 322 ? -32.035 -34.354 21.171 1.00 101.00 ? 354 GLN B OE1 1 ? 
ATOM   4555 N NE2 . GLN B 1 322 ? -32.393 -36.481 20.571 1.00 96.30  ? 354 GLN B NE2 1 ? 
ATOM   4556 N N   . LEU B 1 323 ? -27.943 -32.858 17.222 1.00 83.68  ? 355 LEU B N   1 ? 
ATOM   4557 C CA  . LEU B 1 323 ? -26.790 -31.975 17.358 1.00 75.51  ? 355 LEU B CA  1 ? 
ATOM   4558 C C   . LEU B 1 323 ? -26.569 -31.257 16.040 1.00 67.53  ? 355 LEU B C   1 ? 
ATOM   4559 O O   . LEU B 1 323 ? -26.163 -30.098 16.042 1.00 67.39  ? 355 LEU B O   1 ? 
ATOM   4560 C CB  . LEU B 1 323 ? -25.495 -32.680 17.769 1.00 71.89  ? 355 LEU B CB  1 ? 
ATOM   4561 C CG  . LEU B 1 323 ? -25.468 -33.284 19.176 1.00 67.04  ? 355 LEU B CG  1 ? 
ATOM   4562 C CD1 . LEU B 1 323 ? -24.284 -34.211 19.364 1.00 68.88  ? 355 LEU B CD1 1 ? 
ATOM   4563 C CD2 . LEU B 1 323 ? -25.437 -32.206 20.214 1.00 67.69  ? 355 LEU B CD2 1 ? 
ATOM   4564 N N   . MET B 1 324 ? -26.809 -31.965 14.932 1.00 66.81  ? 356 MET B N   1 ? 
ATOM   4565 C CA  . MET B 1 324 ? -26.489 -31.432 13.617 1.00 76.91  ? 356 MET B CA  1 ? 
ATOM   4566 C C   . MET B 1 324 ? -27.444 -30.288 13.270 1.00 76.17  ? 356 MET B C   1 ? 
ATOM   4567 O O   . MET B 1 324 ? -27.081 -29.404 12.503 1.00 74.14  ? 356 MET B O   1 ? 
ATOM   4568 C CB  . MET B 1 324 ? -26.540 -32.521 12.537 1.00 87.12  ? 356 MET B CB  1 ? 
ATOM   4569 C CG  . MET B 1 324 ? -25.974 -32.088 11.191 1.00 95.64  ? 356 MET B CG  1 ? 
ATOM   4570 S SD  . MET B 1 324 ? -24.172 -32.187 11.139 1.00 117.25 ? 356 MET B SD  1 ? 
ATOM   4571 C CE  . MET B 1 324 ? -23.806 -30.824 10.023 1.00 116.04 ? 356 MET B CE  1 ? 
ATOM   4572 N N   . VAL B 1 325 ? -28.653 -30.274 13.850 1.00 74.09  ? 357 VAL B N   1 ? 
ATOM   4573 C CA  . VAL B 1 325 ? -29.604 -29.215 13.529 1.00 79.17  ? 357 VAL B CA  1 ? 
ATOM   4574 C C   . VAL B 1 325 ? -29.641 -28.200 14.674 1.00 71.74  ? 357 VAL B C   1 ? 
ATOM   4575 O O   . VAL B 1 325 ? -30.447 -27.275 14.643 1.00 68.94  ? 357 VAL B O   1 ? 
ATOM   4576 C CB  . VAL B 1 325 ? -31.025 -29.704 13.153 1.00 72.69  ? 357 VAL B CB  1 ? 
ATOM   4577 C CG1 . VAL B 1 325 ? -31.025 -30.449 11.821 1.00 69.58  ? 357 VAL B CG1 1 ? 
ATOM   4578 C CG2 . VAL B 1 325 ? -31.691 -30.545 14.243 1.00 61.17  ? 357 VAL B CG2 1 ? 
ATOM   4579 N N   . HIS B 1 326 ? -28.747 -28.357 15.660 1.00 65.54  ? 358 HIS B N   1 ? 
ATOM   4580 C CA  . HIS B 1 326 ? -28.663 -27.442 16.790 1.00 61.30  ? 358 HIS B CA  1 ? 
ATOM   4581 C C   . HIS B 1 326 ? -28.098 -26.097 16.340 1.00 64.76  ? 358 HIS B C   1 ? 
ATOM   4582 O O   . HIS B 1 326 ? -27.245 -26.025 15.458 1.00 72.65  ? 358 HIS B O   1 ? 
ATOM   4583 C CB  . HIS B 1 326 ? -27.857 -28.069 17.933 1.00 59.66  ? 358 HIS B CB  1 ? 
ATOM   4584 C CG  . HIS B 1 326 ? -27.833 -27.275 19.199 1.00 54.95  ? 358 HIS B CG  1 ? 
ATOM   4585 N ND1 . HIS B 1 326 ? -27.226 -26.042 19.304 1.00 49.64  ? 358 HIS B ND1 1 ? 
ATOM   4586 C CD2 . HIS B 1 326 ? -28.321 -27.556 20.417 1.00 52.24  ? 358 HIS B CD2 1 ? 
ATOM   4587 C CE1 . HIS B 1 326 ? -27.344 -25.611 20.558 1.00 56.54  ? 358 HIS B CE1 1 ? 
ATOM   4588 N NE2 . HIS B 1 326 ? -28.018 -26.507 21.255 1.00 52.26  ? 358 HIS B NE2 1 ? 
ATOM   4589 N N   . ALA B 1 327 ? -28.608 -25.032 16.963 1.00 71.73  ? 359 ALA B N   1 ? 
ATOM   4590 C CA  . ALA B 1 327 ? -28.352 -23.652 16.566 1.00 71.66  ? 359 ALA B CA  1 ? 
ATOM   4591 C C   . ALA B 1 327 ? -26.850 -23.344 16.514 1.00 66.10  ? 359 ALA B C   1 ? 
ATOM   4592 O O   . ALA B 1 327 ? -26.382 -22.684 15.581 1.00 69.58  ? 359 ALA B O   1 ? 
ATOM   4593 C CB  . ALA B 1 327 ? -29.078 -22.719 17.525 1.00 65.77  ? 359 ALA B CB  1 ? 
ATOM   4594 N N   . PHE B 1 328 ? -26.105 -23.805 17.525 1.00 64.62  ? 360 PHE B N   1 ? 
ATOM   4595 C CA  . PHE B 1 328 ? -24.654 -23.647 17.560 1.00 61.83  ? 360 PHE B CA  1 ? 
ATOM   4596 C C   . PHE B 1 328 ? -24.069 -24.149 16.245 1.00 55.77  ? 360 PHE B C   1 ? 
ATOM   4597 O O   . PHE B 1 328 ? -23.301 -23.447 15.593 1.00 54.69  ? 360 PHE B O   1 ? 
ATOM   4598 C CB  . PHE B 1 328 ? -24.019 -24.357 18.762 1.00 63.66  ? 360 PHE B CB  1 ? 
ATOM   4599 C CG  . PHE B 1 328 ? -22.493 -24.344 18.794 1.00 71.82  ? 360 PHE B CG  1 ? 
ATOM   4600 C CD1 . PHE B 1 328 ? -21.790 -23.166 19.035 1.00 72.75  ? 360 PHE B CD1 1 ? 
ATOM   4601 C CD2 . PHE B 1 328 ? -21.760 -25.514 18.617 1.00 72.15  ? 360 PHE B CD2 1 ? 
ATOM   4602 C CE1 . PHE B 1 328 ? -20.401 -23.156 19.073 1.00 71.74  ? 360 PHE B CE1 1 ? 
ATOM   4603 C CE2 . PHE B 1 328 ? -20.371 -25.495 18.658 1.00 71.54  ? 360 PHE B CE2 1 ? 
ATOM   4604 C CZ  . PHE B 1 328 ? -19.696 -24.318 18.895 1.00 65.22  ? 360 PHE B CZ  1 ? 
ATOM   4605 N N   . ILE B 1 329 ? -24.478 -25.352 15.836 1.00 56.88  ? 361 ILE B N   1 ? 
ATOM   4606 C CA  . ILE B 1 329 ? -23.926 -25.959 14.638 1.00 60.78  ? 361 ILE B CA  1 ? 
ATOM   4607 C C   . ILE B 1 329 ? -24.387 -25.229 13.379 1.00 65.48  ? 361 ILE B C   1 ? 
ATOM   4608 O O   . ILE B 1 329 ? -23.594 -25.083 12.448 1.00 65.48  ? 361 ILE B O   1 ? 
ATOM   4609 C CB  . ILE B 1 329 ? -24.248 -27.458 14.587 1.00 59.56  ? 361 ILE B CB  1 ? 
ATOM   4610 C CG1 . ILE B 1 329 ? -23.570 -28.193 15.742 1.00 60.43  ? 361 ILE B CG1 1 ? 
ATOM   4611 C CG2 . ILE B 1 329 ? -23.863 -28.048 13.230 1.00 59.22  ? 361 ILE B CG2 1 ? 
ATOM   4612 C CD1 . ILE B 1 329 ? -22.050 -28.186 15.695 1.00 58.88  ? 361 ILE B CD1 1 ? 
ATOM   4613 N N   . LYS B 1 330 ? -25.663 -24.816 13.337 1.00 75.77  ? 362 LYS B N   1 ? 
ATOM   4614 C CA  . LYS B 1 330 ? -26.208 -24.115 12.179 1.00 78.13  ? 362 LYS B CA  1 ? 
ATOM   4615 C C   . LYS B 1 330 ? -25.465 -22.795 11.989 1.00 69.60  ? 362 LYS B C   1 ? 
ATOM   4616 O O   . LYS B 1 330 ? -25.038 -22.470 10.880 1.00 70.21  ? 362 LYS B O   1 ? 
ATOM   4617 C CB  . LYS B 1 330 ? -27.703 -23.812 12.333 1.00 89.50  ? 362 LYS B CB  1 ? 
ATOM   4618 C CG  . LYS B 1 330 ? -28.673 -24.971 12.158 1.00 95.95  ? 362 LYS B CG  1 ? 
ATOM   4619 C CD  . LYS B 1 330 ? -29.075 -25.220 10.709 1.00 113.22 ? 362 LYS B CD  1 ? 
ATOM   4620 C CE  . LYS B 1 330 ? -30.096 -26.310 10.540 1.00 121.71 ? 362 LYS B CE  1 ? 
ATOM   4621 N NZ  . LYS B 1 330 ? -31.419 -25.932 11.045 1.00 120.82 ? 362 LYS B NZ  1 ? 
ATOM   4622 N N   . ARG B 1 331 ? -25.300 -22.051 13.089 1.00 59.99  ? 363 ARG B N   1 ? 
ATOM   4623 C CA  . ARG B 1 331 ? -24.567 -20.790 13.064 1.00 61.21  ? 363 ARG B CA  1 ? 
ATOM   4624 C C   . ARG B 1 331 ? -23.141 -21.036 12.565 1.00 61.31  ? 363 ARG B C   1 ? 
ATOM   4625 O O   . ARG B 1 331 ? -22.692 -20.360 11.637 1.00 59.75  ? 363 ARG B O   1 ? 
ATOM   4626 C CB  . ARG B 1 331 ? -24.608 -20.140 14.455 1.00 57.55  ? 363 ARG B CB  1 ? 
ATOM   4627 C CG  . ARG B 1 331 ? -24.102 -18.706 14.559 1.00 57.49  ? 363 ARG B CG  1 ? 
ATOM   4628 C CD  . ARG B 1 331 ? -23.783 -18.299 16.025 1.00 54.07  ? 363 ARG B CD  1 ? 
ATOM   4629 N NE  . ARG B 1 331 ? -22.536 -18.922 16.491 1.00 56.88  ? 363 ARG B NE  1 ? 
ATOM   4630 C CZ  . ARG B 1 331 ? -22.092 -19.122 17.744 1.00 65.97  ? 363 ARG B CZ  1 ? 
ATOM   4631 N NH1 . ARG B 1 331 ? -22.831 -18.881 18.825 1.00 55.19  ? 363 ARG B NH1 1 ? 
ATOM   4632 N NH2 . ARG B 1 331 ? -20.867 -19.598 17.906 1.00 69.80  ? 363 ARG B NH2 1 ? 
ATOM   4633 N N   . SER B 1 332 ? -22.460 -22.028 13.169 1.00 63.85  ? 364 SER B N   1 ? 
ATOM   4634 C CA  . SER B 1 332 ? -21.051 -22.298 12.898 1.00 67.28  ? 364 SER B CA  1 ? 
ATOM   4635 C C   . SER B 1 332 ? -20.853 -22.671 11.431 1.00 67.08  ? 364 SER B C   1 ? 
ATOM   4636 O O   . SER B 1 332 ? -19.892 -22.237 10.809 1.00 64.12  ? 364 SER B O   1 ? 
ATOM   4637 C CB  . SER B 1 332 ? -20.476 -23.374 13.802 1.00 65.19  ? 364 SER B CB  1 ? 
ATOM   4638 O OG  . SER B 1 332 ? -20.510 -23.007 15.176 1.00 72.78  ? 364 SER B OG  1 ? 
ATOM   4639 N N   . ASP B 1 333 ? -21.779 -23.453 10.862 1.00 71.50  ? 365 ASP B N   1 ? 
ATOM   4640 C CA  . ASP B 1 333 ? -21.630 -23.889 9.484  1.00 72.68  ? 365 ASP B CA  1 ? 
ATOM   4641 C C   . ASP B 1 333 ? -21.606 -22.655 8.583  1.00 72.94  ? 365 ASP B C   1 ? 
ATOM   4642 O O   . ASP B 1 333 ? -20.889 -22.633 7.587  1.00 87.07  ? 365 ASP B O   1 ? 
ATOM   4643 C CB  . ASP B 1 333 ? -22.666 -24.949 9.124  1.00 86.43  ? 365 ASP B CB  1 ? 
ATOM   4644 C CG  . ASP B 1 333 ? -22.215 -26.033 8.145  1.00 99.26  ? 365 ASP B CG  1 ? 
ATOM   4645 O OD1 . ASP B 1 333 ? -21.113 -25.903 7.568  1.00 109.18 ? 365 ASP B OD1 1 ? 
ATOM   4646 O OD2 . ASP B 1 333 ? -22.961 -27.021 7.976  1.00 107.88 ? 365 ASP B OD2 1 ? 
ATOM   4647 N N   . ALA B 1 334 ? -22.352 -21.612 8.967  1.00 75.84  ? 366 ALA B N   1 ? 
ATOM   4648 C CA  . ALA B 1 334 ? -22.500 -20.419 8.147  1.00 71.54  ? 366 ALA B CA  1 ? 
ATOM   4649 C C   . ALA B 1 334 ? -21.298 -19.487 8.276  1.00 68.75  ? 366 ALA B C   1 ? 
ATOM   4650 O O   . ALA B 1 334 ? -21.002 -18.753 7.333  1.00 66.55  ? 366 ALA B O   1 ? 
ATOM   4651 C CB  . ALA B 1 334 ? -23.775 -19.692 8.520  1.00 74.78  ? 366 ALA B CB  1 ? 
ATOM   4652 N N   . GLU B 1 335 ? -20.646 -19.474 9.449  1.00 64.51  ? 367 GLU B N   1 ? 
ATOM   4653 C CA  . GLU B 1 335 ? -19.502 -18.598 9.660  1.00 62.72  ? 367 GLU B CA  1 ? 
ATOM   4654 C C   . GLU B 1 335 ? -18.402 -18.982 8.670  1.00 60.37  ? 367 GLU B C   1 ? 
ATOM   4655 O O   . GLU B 1 335 ? -18.118 -20.160 8.477  1.00 66.93  ? 367 GLU B O   1 ? 
ATOM   4656 C CB  . GLU B 1 335 ? -19.029 -18.613 11.116 1.00 64.08  ? 367 GLU B CB  1 ? 
ATOM   4657 C CG  . GLU B 1 335 ? -19.940 -17.828 12.062 1.00 64.79  ? 367 GLU B CG  1 ? 
ATOM   4658 C CD  . GLU B 1 335 ? -19.940 -18.285 13.521 1.00 79.11  ? 367 GLU B CD  1 ? 
ATOM   4659 O OE1 . GLU B 1 335 ? -19.325 -19.327 13.860 1.00 83.12  ? 367 GLU B OE1 1 ? 
ATOM   4660 O OE2 . GLU B 1 335 ? -20.560 -17.578 14.345 1.00 83.31  ? 367 GLU B OE2 1 ? 
ATOM   4661 N N   . GLU B 1 336 ? -17.825 -17.978 8.006  1.00 65.31  ? 368 GLU B N   1 ? 
ATOM   4662 C CA  . GLU B 1 336 ? -16.641 -18.173 7.191  1.00 74.49  ? 368 GLU B CA  1 ? 
ATOM   4663 C C   . GLU B 1 336 ? -15.461 -17.940 8.124  1.00 70.51  ? 368 GLU B C   1 ? 
ATOM   4664 O O   . GLU B 1 336 ? -15.212 -16.804 8.501  1.00 70.50  ? 368 GLU B O   1 ? 
ATOM   4665 C CB  . GLU B 1 336 ? -16.572 -17.225 5.988  1.00 89.95  ? 368 GLU B CB  1 ? 
ATOM   4666 C CG  . GLU B 1 336 ? -17.899 -17.017 5.256  1.00 107.68 ? 368 GLU B CG  1 ? 
ATOM   4667 C CD  . GLU B 1 336 ? -18.748 -15.830 5.712  1.00 118.60 ? 368 GLU B CD  1 ? 
ATOM   4668 O OE1 . GLU B 1 336 ? -19.202 -15.058 4.832  1.00 122.58 ? 368 GLU B OE1 1 ? 
ATOM   4669 O OE2 . GLU B 1 336 ? -18.957 -15.665 6.941  1.00 107.21 ? 368 GLU B OE2 1 ? 
ATOM   4670 N N   . VAL B 1 337 ? -14.785 -19.016 8.545  1.00 73.77  ? 369 VAL B N   1 ? 
ATOM   4671 C CA  . VAL B 1 337 ? -13.732 -18.892 9.542  1.00 74.99  ? 369 VAL B CA  1 ? 
ATOM   4672 C C   . VAL B 1 337 ? -12.393 -19.327 8.957  1.00 63.33  ? 369 VAL B C   1 ? 
ATOM   4673 O O   . VAL B 1 337 ? -12.285 -20.400 8.378  1.00 59.82  ? 369 VAL B O   1 ? 
ATOM   4674 C CB  . VAL B 1 337 ? -14.038 -19.697 10.817 1.00 73.77  ? 369 VAL B CB  1 ? 
ATOM   4675 C CG1 . VAL B 1 337 ? -12.847 -19.728 11.764 1.00 69.53  ? 369 VAL B CG1 1 ? 
ATOM   4676 C CG2 . VAL B 1 337 ? -15.258 -19.147 11.540 1.00 75.26  ? 369 VAL B CG2 1 ? 
ATOM   4677 N N   . ASP B 1 338 ? -11.362 -18.527 9.240  1.00 64.33  ? 370 ASP B N   1 ? 
ATOM   4678 C CA  . ASP B 1 338 ? -10.010 -18.781 8.775  1.00 61.43  ? 370 ASP B CA  1 ? 
ATOM   4679 C C   . ASP B 1 338 ? -9.300  -19.698 9.765  1.00 58.42  ? 370 ASP B C   1 ? 
ATOM   4680 O O   . ASP B 1 338 ? -8.361  -19.296 10.451 1.00 63.74  ? 370 ASP B O   1 ? 
ATOM   4681 C CB  . ASP B 1 338 ? -9.281  -17.465 8.567  1.00 64.96  ? 370 ASP B CB  1 ? 
ATOM   4682 C CG  . ASP B 1 338 ? -7.937  -17.571 7.871  1.00 66.99  ? 370 ASP B CG  1 ? 
ATOM   4683 O OD1 . ASP B 1 338 ? -7.480  -18.716 7.646  1.00 61.95  ? 370 ASP B OD1 1 ? 
ATOM   4684 O OD2 . ASP B 1 338 ? -7.368  -16.499 7.575  1.00 75.51  ? 370 ASP B OD2 1 ? 
ATOM   4685 N N   . PHE B 1 339 ? -9.749  -20.950 9.795  1.00 57.92  ? 371 PHE B N   1 ? 
ATOM   4686 C CA  . PHE B 1 339 ? -9.206  -21.951 10.693 1.00 62.97  ? 371 PHE B CA  1 ? 
ATOM   4687 C C   . PHE B 1 339 ? -7.711  -22.136 10.425 1.00 60.11  ? 371 PHE B C   1 ? 
ATOM   4688 O O   . PHE B 1 339 ? -6.919  -22.237 11.355 1.00 67.95  ? 371 PHE B O   1 ? 
ATOM   4689 C CB  . PHE B 1 339 ? -10.058 -23.210 10.501 1.00 60.65  ? 371 PHE B CB  1 ? 
ATOM   4690 C CG  . PHE B 1 339 ? -9.627  -24.388 11.359 1.00 67.48  ? 371 PHE B CG  1 ? 
ATOM   4691 C CD1 . PHE B 1 339 ? -8.606  -25.230 10.938 1.00 73.02  ? 371 PHE B CD1 1 ? 
ATOM   4692 C CD2 . PHE B 1 339 ? -10.229 -24.640 12.586 1.00 70.53  ? 371 PHE B CD2 1 ? 
ATOM   4693 C CE1 . PHE B 1 339 ? -8.189  -26.285 11.727 1.00 72.92  ? 371 PHE B CE1 1 ? 
ATOM   4694 C CE2 . PHE B 1 339 ? -9.817  -25.708 13.367 1.00 72.68  ? 371 PHE B CE2 1 ? 
ATOM   4695 C CZ  . PHE B 1 339 ? -8.794  -26.521 12.940 1.00 74.83  ? 371 PHE B CZ  1 ? 
ATOM   4696 N N   . ALA B 1 340 ? -7.336  -22.170 9.149  1.00 65.00  ? 372 ALA B N   1 ? 
ATOM   4697 C CA  . ALA B 1 340 ? -5.980  -22.496 8.746  1.00 67.04  ? 372 ALA B CA  1 ? 
ATOM   4698 C C   . ALA B 1 340 ? -5.014  -21.396 9.171  1.00 65.40  ? 372 ALA B C   1 ? 
ATOM   4699 O O   . ALA B 1 340 ? -3.916  -21.680 9.640  1.00 64.32  ? 372 ALA B O   1 ? 
ATOM   4700 C CB  . ALA B 1 340 ? -5.934  -22.707 7.256  1.00 67.57  ? 372 ALA B CB  1 ? 
ATOM   4701 N N   . GLY B 1 341 ? -5.431  -20.142 9.000  1.00 64.87  ? 373 GLY B N   1 ? 
ATOM   4702 C CA  . GLY B 1 341 ? -4.650  -19.022 9.496  1.00 62.04  ? 373 GLY B CA  1 ? 
ATOM   4703 C C   . GLY B 1 341 ? -4.547  -19.046 11.018 1.00 61.57  ? 373 GLY B C   1 ? 
ATOM   4704 O O   . GLY B 1 341 ? -3.516  -18.705 11.587 1.00 59.44  ? 373 GLY B O   1 ? 
ATOM   4705 N N   . TRP B 1 342 ? -5.638  -19.422 11.685 1.00 64.09  ? 374 TRP B N   1 ? 
ATOM   4706 C CA  . TRP B 1 342 ? -5.627  -19.430 13.132 1.00 61.20  ? 374 TRP B CA  1 ? 
ATOM   4707 C C   . TRP B 1 342 ? -4.638  -20.492 13.607 1.00 59.62  ? 374 TRP B C   1 ? 
ATOM   4708 O O   . TRP B 1 342 ? -3.837  -20.224 14.501 1.00 53.78  ? 374 TRP B O   1 ? 
ATOM   4709 C CB  . TRP B 1 342 ? -7.035  -19.622 13.724 1.00 55.72  ? 374 TRP B CB  1 ? 
ATOM   4710 C CG  . TRP B 1 342 ? -6.990  -19.808 15.218 1.00 47.80  ? 374 TRP B CG  1 ? 
ATOM   4711 C CD1 . TRP B 1 342 ? -6.956  -18.840 16.178 1.00 46.84  ? 374 TRP B CD1 1 ? 
ATOM   4712 C CD2 . TRP B 1 342 ? -6.868  -21.063 15.915 1.00 42.98  ? 374 TRP B CD2 1 ? 
ATOM   4713 N NE1 . TRP B 1 342 ? -6.857  -19.397 17.425 1.00 43.59  ? 374 TRP B NE1 1 ? 
ATOM   4714 C CE2 . TRP B 1 342 ? -6.782  -20.760 17.294 1.00 45.17  ? 374 TRP B CE2 1 ? 
ATOM   4715 C CE3 . TRP B 1 342 ? -6.823  -22.401 15.508 1.00 49.13  ? 374 TRP B CE3 1 ? 
ATOM   4716 C CZ2 . TRP B 1 342 ? -6.643  -21.752 18.262 1.00 45.70  ? 374 TRP B CZ2 1 ? 
ATOM   4717 C CZ3 . TRP B 1 342 ? -6.694  -23.386 16.465 1.00 51.06  ? 374 TRP B CZ3 1 ? 
ATOM   4718 C CH2 . TRP B 1 342 ? -6.593  -23.060 17.820 1.00 54.27  ? 374 TRP B CH2 1 ? 
ATOM   4719 N N   . LEU B 1 343 ? -4.704  -21.677 12.985 1.00 60.23  ? 375 LEU B N   1 ? 
ATOM   4720 C CA  . LEU B 1 343 ? -3.960  -22.851 13.424 1.00 63.66  ? 375 LEU B CA  1 ? 
ATOM   4721 C C   . LEU B 1 343 ? -2.470  -22.624 13.206 1.00 61.88  ? 375 LEU B C   1 ? 
ATOM   4722 O O   . LEU B 1 343 ? -1.677  -22.859 14.116 1.00 56.21  ? 375 LEU B O   1 ? 
ATOM   4723 C CB  . LEU B 1 343 ? -4.418  -24.103 12.679 1.00 67.80  ? 375 LEU B CB  1 ? 
ATOM   4724 C CG  . LEU B 1 343 ? -3.568  -25.365 12.876 1.00 66.75  ? 375 LEU B CG  1 ? 
ATOM   4725 C CD1 . LEU B 1 343 ? -3.655  -25.938 14.286 1.00 67.75  ? 375 LEU B CD1 1 ? 
ATOM   4726 C CD2 . LEU B 1 343 ? -3.970  -26.426 11.863 1.00 67.80  ? 375 LEU B CD2 1 ? 
ATOM   4727 N N   . CYS B 1 344 ? -2.132  -22.184 11.984 1.00 54.61  ? 376 CYS B N   1 ? 
ATOM   4728 C CA  . CYS B 1 344 ? -0.768  -21.896 11.569 1.00 55.81  ? 376 CYS B CA  1 ? 
ATOM   4729 C C   . CYS B 1 344 ? -0.131  -20.834 12.462 1.00 55.85  ? 376 CYS B C   1 ? 
ATOM   4730 O O   . CYS B 1 344 ? 0.989   -21.025 12.920 1.00 62.03  ? 376 CYS B O   1 ? 
ATOM   4731 C CB  . CYS B 1 344 ? -0.716  -21.465 10.106 1.00 57.22  ? 376 CYS B CB  1 ? 
ATOM   4732 S SG  . CYS B 1 344 ? -1.025  -22.845 8.972  1.00 68.34  ? 376 CYS B SG  1 ? 
ATOM   4733 N N   . SER B 1 345 ? -0.843  -19.735 12.735 1.00 54.13  ? 377 SER B N   1 ? 
ATOM   4734 C CA  . SER B 1 345 ? -0.349  -18.736 13.670 1.00 57.32  ? 377 SER B CA  1 ? 
ATOM   4735 C C   . SER B 1 345 ? -0.151  -19.345 15.056 1.00 59.02  ? 377 SER B C   1 ? 
ATOM   4736 O O   . SER B 1 345 ? 0.833   -19.045 15.727 1.00 61.56  ? 377 SER B O   1 ? 
ATOM   4737 C CB  . SER B 1 345 ? -1.245  -17.555 13.720 1.00 59.73  ? 377 SER B CB  1 ? 
ATOM   4738 O OG  . SER B 1 345 ? -1.513  -17.081 12.407 1.00 63.79  ? 377 SER B OG  1 ? 
ATOM   4739 N N   . THR B 1 346 ? -1.050  -20.247 15.458 1.00 60.24  ? 378 THR B N   1 ? 
ATOM   4740 C CA  . THR B 1 346 ? -1.052  -20.759 16.820 1.00 60.18  ? 378 THR B CA  1 ? 
ATOM   4741 C C   . THR B 1 346 ? 0.175   -21.625 17.058 1.00 58.54  ? 378 THR B C   1 ? 
ATOM   4742 O O   . THR B 1 346 ? 0.870   -21.443 18.049 1.00 61.79  ? 378 THR B O   1 ? 
ATOM   4743 C CB  . THR B 1 346 ? -2.330  -21.540 17.112 1.00 55.92  ? 378 THR B CB  1 ? 
ATOM   4744 O OG1 . THR B 1 346 ? -3.375  -20.573 17.095 1.00 62.95  ? 378 THR B OG1 1 ? 
ATOM   4745 C CG2 . THR B 1 346 ? -2.297  -22.182 18.486 1.00 57.01  ? 378 THR B CG2 1 ? 
ATOM   4746 N N   . ILE B 1 347 ? 0.404   -22.586 16.162 1.00 66.32  ? 379 ILE B N   1 ? 
ATOM   4747 C CA  . ILE B 1 347 ? 1.409   -23.609 16.392 1.00 67.35  ? 379 ILE B CA  1 ? 
ATOM   4748 C C   . ILE B 1 347 ? 2.730   -23.223 15.739 1.00 63.78  ? 379 ILE B C   1 ? 
ATOM   4749 O O   . ILE B 1 347 ? 3.690   -23.951 15.893 1.00 65.03  ? 379 ILE B O   1 ? 
ATOM   4750 C CB  . ILE B 1 347 ? 0.943   -24.990 15.897 1.00 65.95  ? 379 ILE B CB  1 ? 
ATOM   4751 C CG1 . ILE B 1 347 ? 0.694   -25.012 14.389 1.00 62.51  ? 379 ILE B CG1 1 ? 
ATOM   4752 C CG2 . ILE B 1 347 ? -0.272  -25.460 16.693 1.00 66.14  ? 379 ILE B CG2 1 ? 
ATOM   4753 C CD1 . ILE B 1 347 ? 0.338   -26.382 13.838 1.00 64.76  ? 379 ILE B CD1 1 ? 
ATOM   4754 N N   . GLY B 1 348 ? 2.766   -22.116 14.995 1.00 68.24  ? 380 GLY B N   1 ? 
ATOM   4755 C CA  . GLY B 1 348 ? 3.998   -21.618 14.411 1.00 71.73  ? 380 GLY B CA  1 ? 
ATOM   4756 C C   . GLY B 1 348 ? 4.411   -22.411 13.172 1.00 77.03  ? 380 GLY B C   1 ? 
ATOM   4757 O O   . GLY B 1 348 ? 5.590   -22.701 12.990 1.00 80.32  ? 380 GLY B O   1 ? 
ATOM   4758 N N   . LEU B 1 349 ? 3.443   -22.733 12.311 1.00 77.31  ? 381 LEU B N   1 ? 
ATOM   4759 C CA  . LEU B 1 349 ? 3.732   -23.429 11.069 1.00 86.64  ? 381 LEU B CA  1 ? 
ATOM   4760 C C   . LEU B 1 349 ? 3.716   -22.432 9.914  1.00 96.64  ? 381 LEU B C   1 ? 
ATOM   4761 O O   . LEU B 1 349 ? 2.853   -21.558 9.874  1.00 95.60  ? 381 LEU B O   1 ? 
ATOM   4762 C CB  . LEU B 1 349 ? 2.712   -24.544 10.872 1.00 83.44  ? 381 LEU B CB  1 ? 
ATOM   4763 C CG  . LEU B 1 349 ? 2.996   -25.503 9.716  1.00 83.28  ? 381 LEU B CG  1 ? 
ATOM   4764 C CD1 . LEU B 1 349 ? 2.776   -26.936 10.148 1.00 91.01  ? 381 LEU B CD1 1 ? 
ATOM   4765 C CD2 . LEU B 1 349 ? 2.102   -25.167 8.543  1.00 86.18  ? 381 LEU B CD2 1 ? 
ATOM   4766 N N   . ASN B 1 350 ? 4.677   -22.576 8.989  1.00 104.10 ? 382 ASN B N   1 ? 
ATOM   4767 C CA  . ASN B 1 350 ? 4.805   -21.681 7.847  1.00 116.62 ? 382 ASN B CA  1 ? 
ATOM   4768 C C   . ASN B 1 350 ? 4.034   -22.249 6.658  1.00 134.43 ? 382 ASN B C   1 ? 
ATOM   4769 O O   . ASN B 1 350 ? 4.585   -22.982 5.838  1.00 146.08 ? 382 ASN B O   1 ? 
ATOM   4770 C CB  . ASN B 1 350 ? 6.262   -21.384 7.512  1.00 113.11 ? 382 ASN B CB  1 ? 
ATOM   4771 C CG  . ASN B 1 350 ? 6.762   -20.165 8.246  1.00 113.98 ? 382 ASN B CG  1 ? 
ATOM   4772 O OD1 . ASN B 1 350 ? 7.090   -19.157 7.611  1.00 131.46 ? 382 ASN B OD1 1 ? 
ATOM   4773 N ND2 . ASN B 1 350 ? 6.808   -20.227 9.569  1.00 106.24 ? 382 ASN B ND2 1 ? 
ATOM   4774 N N   . GLN B 1 351 ? 2.749   -21.877 6.592  1.00 148.92 ? 383 GLN B N   1 ? 
ATOM   4775 C CA  . GLN B 1 351 ? 1.842   -22.242 5.514  1.00 156.31 ? 383 GLN B CA  1 ? 
ATOM   4776 C C   . GLN B 1 351 ? 2.557   -22.130 4.153  1.00 158.97 ? 383 GLN B C   1 ? 
ATOM   4777 O O   . GLN B 1 351 ? 2.686   -20.989 3.652  1.00 161.29 ? 383 GLN B O   1 ? 
ATOM   4778 C CB  . GLN B 1 351 ? 0.613   -21.341 5.669  1.00 156.82 ? 383 GLN B CB  1 ? 
ATOM   4779 C CG  . GLN B 1 351 ? -0.367  -21.350 4.499  1.00 161.90 ? 383 GLN B CG  1 ? 
ATOM   4780 C CD  . GLN B 1 351 ? -1.111  -22.657 4.339  1.00 166.33 ? 383 GLN B CD  1 ? 
ATOM   4781 O OE1 . GLN B 1 351 ? -0.578  -23.641 3.812  1.00 174.88 ? 383 GLN B OE1 1 ? 
ATOM   4782 N NE2 . GLN B 1 351 ? -2.365  -22.670 4.768  1.00 163.40 ? 383 GLN B NE2 1 ? 
HETATM 4783 C C3  . WNT C 2 .   ? -10.809 1.226   19.541 1.00 57.70  ? 401 WNT A C3  1 ? 
HETATM 4784 C C5  . WNT C 2 .   ? -10.528 1.003   21.924 1.00 52.74  ? 401 WNT A C5  1 ? 
HETATM 4785 C C6  . WNT C 2 .   ? -11.166 -0.232  21.844 1.00 46.02  ? 401 WNT A C6  1 ? 
HETATM 4786 C C9  . WNT C 2 .   ? -9.317  1.092   25.683 1.00 80.00  ? 401 WNT A C9  1 ? 
HETATM 4787 C C10 . WNT C 2 .   ? -7.748  1.069   25.683 1.00 81.46  ? 401 WNT A C10 1 ? 
HETATM 4788 C C11 . WNT C 2 .   ? -7.191  2.215   26.591 1.00 79.98  ? 401 WNT A C11 1 ? 
HETATM 4789 C C8  . WNT C 2 .   ? -9.809  0.682   24.328 1.00 66.99  ? 401 WNT A C8  1 ? 
HETATM 4790 C C2  . WNT C 2 .   ? -11.463 -0.019  19.472 1.00 59.77  ? 401 WNT A C2  1 ? 
HETATM 4791 C C7  . WNT C 2 .   ? -10.054 1.451   23.273 1.00 61.66  ? 401 WNT A C7  1 ? 
HETATM 4792 C C16 . WNT C 2 .   ? -9.067  5.082   21.945 1.00 65.24  ? 401 WNT A C16 1 ? 
HETATM 4793 C C15 . WNT C 2 .   ? -8.253  4.885   23.262 1.00 63.92  ? 401 WNT A C15 1 ? 
HETATM 4794 C C13 . WNT C 2 .   ? -6.677  2.998   24.171 1.00 82.84  ? 401 WNT A C13 1 ? 
HETATM 4795 C C12 . WNT C 2 .   ? -6.862  3.395   25.652 1.00 84.79  ? 401 WNT A C12 1 ? 
HETATM 4796 C C18 . WNT C 2 .   ? -9.644  3.141   20.728 1.00 54.99  ? 401 WNT A C18 1 ? 
HETATM 4797 C C17 . WNT C 2 .   ? -10.021 6.263   22.167 1.00 63.11  ? 401 WNT A C17 1 ? 
HETATM 4798 C C   . WNT C 2 .   ? -12.942 -2.377  19.443 1.00 62.09  ? 401 WNT A C   1 ? 
HETATM 4799 O O   . WNT C 2 .   ? -12.265 -1.967  20.617 1.00 59.14  ? 401 WNT A O   1 ? 
HETATM 4800 C C1  . WNT C 2 .   ? -11.635 -0.752  20.640 1.00 57.42  ? 401 WNT A C1  1 ? 
HETATM 4801 C C14 . WNT C 2 .   ? -6.751  4.235   23.112 1.00 72.52  ? 401 WNT A C14 1 ? 
HETATM 4802 C C4  . WNT C 2 .   ? -10.337 1.744   20.745 1.00 53.18  ? 401 WNT A C4  1 ? 
HETATM 4803 O O1  . WNT C 2 .   ? -10.640 1.931   18.405 1.00 60.92  ? 401 WNT A O1  1 ? 
HETATM 4804 O O2  . WNT C 2 .   ? -7.286  -0.146  26.161 1.00 90.76  ? 401 WNT A O2  1 ? 
HETATM 4805 O O3  . WNT C 2 .   ? -8.255  2.657   27.396 1.00 98.74  ? 401 WNT A O3  1 ? 
HETATM 4806 O O4  . WNT C 2 .   ? -6.758  4.505   26.044 1.00 79.68  ? 401 WNT A O4  1 ? 
HETATM 4807 O O5  . WNT C 2 .   ? -9.951  3.977   21.770 1.00 70.10  ? 401 WNT A O5  1 ? 
HETATM 4808 O O6  . WNT C 2 .   ? -8.953  3.486   19.855 1.00 67.71  ? 401 WNT A O6  1 ? 
HETATM 4809 C C1  . GOL D 3 .   ? -19.623 -14.917 20.723 1.00 122.24 ? 401 GOL B C1  1 ? 
HETATM 4810 O O1  . GOL D 3 .   ? -20.871 -14.941 20.033 1.00 122.30 ? 401 GOL B O1  1 ? 
HETATM 4811 C C2  . GOL D 3 .   ? -18.449 -14.985 19.766 1.00 121.67 ? 401 GOL B C2  1 ? 
HETATM 4812 O O2  . GOL D 3 .   ? -17.221 -15.017 20.498 1.00 113.88 ? 401 GOL B O2  1 ? 
HETATM 4813 C C3  . GOL D 3 .   ? -18.531 -16.168 18.821 1.00 113.12 ? 401 GOL B C3  1 ? 
HETATM 4814 O O3  . GOL D 3 .   ? -19.037 -15.801 17.539 1.00 104.80 ? 401 GOL B O3  1 ? 
HETATM 4815 C C3  . WNT E 2 .   ? -0.098  -36.887 13.152 1.00 64.79  ? 402 WNT B C3  1 ? 
HETATM 4816 C C5  . WNT E 2 .   ? 0.383   -37.508 15.450 1.00 61.80  ? 402 WNT B C5  1 ? 
HETATM 4817 C C6  . WNT E 2 .   ? 0.964   -36.244 15.602 1.00 65.83  ? 402 WNT B C6  1 ? 
HETATM 4818 C C9  . WNT E 2 .   ? -1.869  -38.443 17.844 1.00 85.96  ? 402 WNT B C9  1 ? 
HETATM 4819 C C10 . WNT E 2 .   ? -2.268  -38.849 19.310 1.00 85.19  ? 402 WNT B C10 1 ? 
HETATM 4820 C C11 . WNT E 2 .   ? -3.483  -39.854 19.294 1.00 96.13  ? 402 WNT B C11 1 ? 
HETATM 4821 C C8  . WNT E 2 .   ? -0.428  -38.794 17.607 1.00 71.40  ? 402 WNT B C8  1 ? 
HETATM 4822 C C2  . WNT E 2 .   ? 0.486   -35.620 13.334 1.00 71.44  ? 402 WNT B C2  1 ? 
HETATM 4823 C C7  . WNT E 2 .   ? 0.436   -38.420 16.663 1.00 64.95  ? 402 WNT B C7  1 ? 
HETATM 4824 C C16 . WNT E 2 .   ? -1.540  -41.411 14.451 1.00 68.70  ? 402 WNT B C16 1 ? 
HETATM 4825 C C15 . WNT E 2 .   ? -2.219  -41.934 15.779 1.00 81.63  ? 402 WNT B C15 1 ? 
HETATM 4826 C C13 . WNT E 2 .   ? -4.119  -41.738 17.596 1.00 98.24  ? 402 WNT B C13 1 ? 
HETATM 4827 C C12 . WNT E 2 .   ? -3.087  -41.193 18.616 1.00 97.69  ? 402 WNT B C12 1 ? 
HETATM 4828 C C18 . WNT E 2 .   ? -0.839  -39.218 13.820 1.00 64.88  ? 402 WNT B C18 1 ? 
HETATM 4829 C C17 . WNT E 2 .   ? -0.522  -42.468 13.994 1.00 70.19  ? 402 WNT B C17 1 ? 
HETATM 4830 C C   . WNT E 2 .   ? 2.218   -33.418 13.694 1.00 64.92  ? 402 WNT B C   1 ? 
HETATM 4831 O O   . WNT E 2 .   ? 1.600   -34.080 14.783 1.00 62.42  ? 402 WNT B O   1 ? 
HETATM 4832 C C1  . WNT E 2 .   ? 1.020   -35.302 14.572 1.00 62.26  ? 402 WNT B C1  1 ? 
HETATM 4833 C C14 . WNT E 2 .   ? -3.800  -41.539 16.021 1.00 89.85  ? 402 WNT B C14 1 ? 
HETATM 4834 C C4  . WNT E 2 .   ? -0.158  -37.845 14.177 1.00 59.00  ? 402 WNT B C4  1 ? 
HETATM 4835 O O1  . WNT E 2 .   ? -0.613  -37.174 11.937 1.00 64.06  ? 402 WNT B O1  1 ? 
HETATM 4836 O O2  . WNT E 2 .   ? -1.198  -39.459 19.955 1.00 99.37  ? 402 WNT B O2  1 ? 
HETATM 4837 O O3  . WNT E 2 .   ? -3.718  -40.188 20.644 1.00 106.04 ? 402 WNT B O3  1 ? 
HETATM 4838 O O4  . WNT E 2 .   ? -2.092  -41.766 18.897 1.00 101.38 ? 402 WNT B O4  1 ? 
HETATM 4839 O O5  . WNT E 2 .   ? -0.747  -40.245 14.739 1.00 76.67  ? 402 WNT B O5  1 ? 
HETATM 4840 O O6  . WNT E 2 .   ? -1.393  -39.367 12.800 1.00 61.50  ? 402 WNT B O6  1 ? 
HETATM 4841 O O   . HOH F 4 .   ? 17.564  -3.217  40.777 1.00 89.56  ? 501 HOH A O   1 ? 
HETATM 4842 O O   . HOH F 4 .   ? 11.440  -4.389  10.025 1.00 76.08  ? 502 HOH A O   1 ? 
HETATM 4843 O O   . HOH F 4 .   ? 8.159   -14.994 14.953 1.00 67.62  ? 503 HOH A O   1 ? 
HETATM 4844 O O   . HOH F 4 .   ? 14.743  -12.368 31.187 1.00 57.13  ? 504 HOH A O   1 ? 
HETATM 4845 O O   . HOH F 4 .   ? 7.523   -17.144 32.925 1.00 73.21  ? 505 HOH A O   1 ? 
HETATM 4846 O O   . HOH F 4 .   ? -1.301  -6.313  0.508  1.00 100.94 ? 506 HOH A O   1 ? 
HETATM 4847 O O   . HOH F 4 .   ? -8.325  -2.127  27.349 1.00 73.97  ? 507 HOH A O   1 ? 
HETATM 4848 O O   . HOH F 4 .   ? 6.165   -20.999 21.009 1.00 50.02  ? 508 HOH A O   1 ? 
HETATM 4849 O O   . HOH F 4 .   ? -14.398 -17.442 17.993 1.00 63.12  ? 509 HOH A O   1 ? 
HETATM 4850 O O   . HOH F 4 .   ? -3.392  3.700   28.495 1.00 82.01  ? 510 HOH A O   1 ? 
HETATM 4851 O O   . HOH F 4 .   ? 1.925   -18.130 24.020 1.00 51.05  ? 511 HOH A O   1 ? 
HETATM 4852 O O   . HOH F 4 .   ? 9.240   -14.934 34.449 1.00 81.28  ? 512 HOH A O   1 ? 
HETATM 4853 O O   . HOH F 4 .   ? -12.558 -1.572  31.190 1.00 99.34  ? 513 HOH A O   1 ? 
HETATM 4854 O O   . HOH F 4 .   ? 10.621  13.483  26.016 1.00 104.22 ? 514 HOH A O   1 ? 
HETATM 4855 O O   . HOH F 4 .   ? -2.282  -18.865 30.605 1.00 73.67  ? 515 HOH A O   1 ? 
HETATM 4856 O O   . HOH F 4 .   ? 6.259   -13.312 12.981 1.00 63.71  ? 516 HOH A O   1 ? 
HETATM 4857 O O   . HOH F 4 .   ? 2.089   -18.961 10.081 1.00 70.60  ? 517 HOH A O   1 ? 
HETATM 4858 O O   . HOH F 4 .   ? -11.578 -16.234 10.875 1.00 56.15  ? 518 HOH A O   1 ? 
HETATM 4859 O O   . HOH F 4 .   ? -3.989  10.425  12.918 1.00 65.70  ? 519 HOH A O   1 ? 
HETATM 4860 O O   . HOH F 4 .   ? 12.735  -1.993  0.181  1.00 95.51  ? 520 HOH A O   1 ? 
HETATM 4861 O O   . HOH F 4 .   ? 17.427  3.641   21.232 1.00 84.96  ? 521 HOH A O   1 ? 
HETATM 4862 O O   . HOH F 4 .   ? -0.280  2.808   7.063  1.00 60.98  ? 522 HOH A O   1 ? 
HETATM 4863 O O   . HOH F 4 .   ? 9.356   1.591   32.170 1.00 79.54  ? 523 HOH A O   1 ? 
HETATM 4864 O O   . HOH F 4 .   ? 1.476   8.745   21.555 1.00 88.40  ? 524 HOH A O   1 ? 
HETATM 4865 O O   . HOH F 4 .   ? 15.720  12.654  15.509 1.00 86.97  ? 525 HOH A O   1 ? 
HETATM 4866 O O   . HOH F 4 .   ? -14.280 -15.853 20.231 1.00 60.77  ? 526 HOH A O   1 ? 
HETATM 4867 O O   . HOH F 4 .   ? 2.662   -30.224 29.403 1.00 93.69  ? 527 HOH A O   1 ? 
HETATM 4868 O O   . HOH F 4 .   ? -5.090  -6.421  37.958 1.00 86.26  ? 528 HOH A O   1 ? 
HETATM 4869 O O   . HOH F 4 .   ? 16.490  -15.261 1.929  1.00 100.19 ? 529 HOH A O   1 ? 
HETATM 4870 O O   . HOH F 4 .   ? 3.466   -18.983 16.977 1.00 57.31  ? 530 HOH A O   1 ? 
HETATM 4871 O O   . HOH F 4 .   ? 16.337  -17.188 29.993 1.00 69.24  ? 531 HOH A O   1 ? 
HETATM 4872 O O   . HOH F 4 .   ? 11.900  15.987  15.351 1.00 88.61  ? 532 HOH A O   1 ? 
HETATM 4873 O O   . HOH F 4 .   ? -2.350  5.025   11.399 1.00 64.34  ? 533 HOH A O   1 ? 
HETATM 4874 O O   . HOH F 4 .   ? 7.940   6.047   28.835 1.00 108.71 ? 534 HOH A O   1 ? 
HETATM 4875 O O   . HOH F 4 .   ? 4.391   -5.611  12.352 1.00 69.76  ? 535 HOH A O   1 ? 
HETATM 4876 O O   . HOH F 4 .   ? 16.487  11.687  17.738 1.00 99.81  ? 536 HOH A O   1 ? 
HETATM 4877 O O   . HOH F 4 .   ? -18.705 -9.836  14.593 1.00 70.71  ? 537 HOH A O   1 ? 
HETATM 4878 O O   . HOH F 4 .   ? 1.149   -2.189  12.248 1.00 74.43  ? 538 HOH A O   1 ? 
HETATM 4879 O O   . HOH F 4 .   ? 13.026  -15.318 28.154 1.00 57.59  ? 539 HOH A O   1 ? 
HETATM 4880 O O   . HOH F 4 .   ? -16.201 -2.789  17.890 1.00 66.45  ? 540 HOH A O   1 ? 
HETATM 4881 O O   . HOH F 4 .   ? 12.468  -8.115  38.370 1.00 79.54  ? 541 HOH A O   1 ? 
HETATM 4882 O O   . HOH F 4 .   ? -0.736  8.234   12.980 1.00 66.97  ? 542 HOH A O   1 ? 
HETATM 4883 O O   . HOH F 4 .   ? 1.970   0.351   35.311 1.00 88.19  ? 543 HOH A O   1 ? 
HETATM 4884 O O   . HOH F 4 .   ? 15.733  3.682   16.164 1.00 90.79  ? 544 HOH A O   1 ? 
HETATM 4885 O O   . HOH F 4 .   ? 16.380  -15.448 12.395 1.00 69.49  ? 545 HOH A O   1 ? 
HETATM 4886 O O   . HOH F 4 .   ? 3.646   -19.962 20.619 1.00 49.44  ? 546 HOH A O   1 ? 
HETATM 4887 O O   . HOH F 4 .   ? 6.817   -11.221 5.289  1.00 79.33  ? 547 HOH A O   1 ? 
HETATM 4888 O O   . HOH F 4 .   ? -10.634 -1.703  11.927 1.00 55.37  ? 548 HOH A O   1 ? 
HETATM 4889 O O   . HOH F 4 .   ? 8.378   17.463  16.211 1.00 108.81 ? 549 HOH A O   1 ? 
HETATM 4890 O O   . HOH F 4 .   ? 8.205   -7.698  5.057  1.00 102.02 ? 550 HOH A O   1 ? 
HETATM 4891 O O   . HOH F 4 .   ? -6.002  -14.868 29.666 1.00 80.15  ? 551 HOH A O   1 ? 
HETATM 4892 O O   . HOH F 4 .   ? 14.671  -22.664 19.204 1.00 54.22  ? 552 HOH A O   1 ? 
HETATM 4893 O O   . HOH F 4 .   ? -0.295  11.248  4.942  1.00 76.22  ? 553 HOH A O   1 ? 
HETATM 4894 O O   . HOH F 4 .   ? -10.947 -3.877  23.490 1.00 73.58  ? 554 HOH A O   1 ? 
HETATM 4895 O O   . HOH F 4 .   ? 9.622   9.489   32.532 1.00 91.38  ? 555 HOH A O   1 ? 
HETATM 4896 O O   . HOH F 4 .   ? 8.665   -23.961 20.327 1.00 75.66  ? 556 HOH A O   1 ? 
HETATM 4897 O O   . HOH F 4 .   ? -4.743  15.235  39.614 1.00 84.48  ? 557 HOH A O   1 ? 
HETATM 4898 O O   . HOH F 4 .   ? 11.578  -22.510 32.777 1.00 86.45  ? 558 HOH A O   1 ? 
HETATM 4899 O O   . HOH F 4 .   ? 21.632  -6.092  23.409 1.00 76.98  ? 559 HOH A O   1 ? 
HETATM 4900 O O   . HOH F 4 .   ? 0.278   10.236  30.626 1.00 84.91  ? 560 HOH A O   1 ? 
HETATM 4901 O O   . HOH F 4 .   ? -16.160 9.798   32.995 1.00 98.93  ? 561 HOH A O   1 ? 
HETATM 4902 O O   . HOH F 4 .   ? 1.053   -8.726  10.598 1.00 75.24  ? 562 HOH A O   1 ? 
HETATM 4903 O O   . HOH F 4 .   ? 19.816  4.003   23.973 1.00 87.13  ? 563 HOH A O   1 ? 
HETATM 4904 O O   . HOH F 4 .   ? 2.005   -4.530  11.204 1.00 74.50  ? 564 HOH A O   1 ? 
HETATM 4905 O O   . HOH F 4 .   ? -17.806 -4.056  19.881 1.00 80.07  ? 565 HOH A O   1 ? 
HETATM 4906 O O   . HOH F 4 .   ? -2.535  -17.592 35.609 1.00 80.06  ? 566 HOH A O   1 ? 
HETATM 4907 O O   . HOH F 4 .   ? -4.562  -20.126 28.984 1.00 72.11  ? 567 HOH A O   1 ? 
HETATM 4908 O O   . HOH F 4 .   ? 9.892   16.567  13.837 1.00 81.72  ? 568 HOH A O   1 ? 
HETATM 4909 O O   . HOH F 4 .   ? -5.777  9.135   24.117 1.00 74.41  ? 569 HOH A O   1 ? 
HETATM 4910 O O   . HOH F 4 .   ? -19.822 -6.217  15.952 1.00 85.58  ? 570 HOH A O   1 ? 
HETATM 4911 O O   . HOH F 4 .   ? -19.973 19.400  7.161  1.00 109.83 ? 571 HOH A O   1 ? 
HETATM 4912 O O   . HOH F 4 .   ? -21.835 7.021   2.545  1.00 92.61  ? 572 HOH A O   1 ? 
HETATM 4913 O O   . HOH F 4 .   ? 12.106  -15.097 2.691  1.00 91.05  ? 573 HOH A O   1 ? 
HETATM 4914 O O   . HOH F 4 .   ? 6.429   -30.013 31.829 1.00 84.56  ? 574 HOH A O   1 ? 
HETATM 4915 O O   . HOH F 4 .   ? 11.452  17.986  9.406  1.00 98.61  ? 575 HOH A O   1 ? 
HETATM 4916 O O   . HOH G 4 .   ? 8.504   -57.825 3.844  1.00 91.61  ? 501 HOH B O   1 ? 
HETATM 4917 O O   . HOH G 4 .   ? -22.034 -15.749 13.795 1.00 69.50  ? 502 HOH B O   1 ? 
HETATM 4918 O O   . HOH G 4 .   ? -12.202 -20.608 24.747 1.00 58.19  ? 503 HOH B O   1 ? 
HETATM 4919 O O   . HOH G 4 .   ? 3.255   -20.982 18.335 1.00 57.52  ? 504 HOH B O   1 ? 
HETATM 4920 O O   . HOH G 4 .   ? 11.292  -40.937 -2.732 1.00 75.53  ? 505 HOH B O   1 ? 
HETATM 4921 O O   . HOH G 4 .   ? 0.629   -38.344 4.916  1.00 70.09  ? 506 HOH B O   1 ? 
HETATM 4922 O O   . HOH G 4 .   ? -19.309 -20.643 16.030 1.00 66.68  ? 507 HOH B O   1 ? 
HETATM 4923 O O   . HOH G 4 .   ? -13.060 -47.474 21.010 1.00 89.34  ? 508 HOH B O   1 ? 
HETATM 4924 O O   . HOH G 4 .   ? -4.406  -24.681 27.986 1.00 63.25  ? 509 HOH B O   1 ? 
HETATM 4925 O O   . HOH G 4 .   ? -27.898 -18.008 15.858 1.00 76.71  ? 510 HOH B O   1 ? 
HETATM 4926 O O   . HOH G 4 .   ? -0.927  -32.287 6.625  1.00 66.94  ? 511 HOH B O   1 ? 
HETATM 4927 O O   . HOH G 4 .   ? -9.432  -38.002 4.265  1.00 86.09  ? 512 HOH B O   1 ? 
HETATM 4928 O O   . HOH G 4 .   ? -15.814 -28.302 10.091 1.00 71.41  ? 513 HOH B O   1 ? 
HETATM 4929 O O   . HOH G 4 .   ? -7.044  -17.789 19.606 1.00 50.38  ? 514 HOH B O   1 ? 
HETATM 4930 O O   . HOH G 4 .   ? -6.632  -35.526 25.096 1.00 66.82  ? 515 HOH B O   1 ? 
HETATM 4931 O O   . HOH G 4 .   ? -22.619 -25.247 29.396 1.00 56.56  ? 516 HOH B O   1 ? 
HETATM 4932 O O   . HOH G 4 .   ? -25.136 -15.588 23.129 1.00 62.52  ? 517 HOH B O   1 ? 
HETATM 4933 O O   . HOH G 4 .   ? -5.010  -13.556 34.823 1.00 96.82  ? 518 HOH B O   1 ? 
HETATM 4934 O O   . HOH G 4 .   ? 2.041   -20.459 23.083 1.00 54.86  ? 519 HOH B O   1 ? 
HETATM 4935 O O   . HOH G 4 .   ? 5.035   -65.785 10.366 1.00 89.82  ? 520 HOH B O   1 ? 
HETATM 4936 O O   . HOH G 4 .   ? 0.468   -29.390 17.163 1.00 73.28  ? 521 HOH B O   1 ? 
HETATM 4937 O O   . HOH G 4 .   ? -17.468 -21.882 13.115 1.00 57.37  ? 522 HOH B O   1 ? 
HETATM 4938 O O   . HOH G 4 .   ? -16.926 -16.568 23.075 1.00 53.21  ? 523 HOH B O   1 ? 
HETATM 4939 O O   . HOH G 4 .   ? -20.605 -34.020 46.435 1.00 102.77 ? 524 HOH B O   1 ? 
HETATM 4940 O O   . HOH G 4 .   ? 0.586   -51.867 2.330  1.00 86.91  ? 525 HOH B O   1 ? 
HETATM 4941 O O   . HOH G 4 .   ? -14.646 -21.713 7.183  1.00 75.77  ? 526 HOH B O   1 ? 
HETATM 4942 O O   . HOH G 4 .   ? -1.004  -50.604 -4.819 1.00 81.58  ? 527 HOH B O   1 ? 
HETATM 4943 O O   . HOH G 4 .   ? -14.425 -17.661 22.168 1.00 56.38  ? 528 HOH B O   1 ? 
HETATM 4944 O O   . HOH G 4 .   ? -26.474 -22.664 8.214  1.00 86.55  ? 529 HOH B O   1 ? 
HETATM 4945 O O   . HOH G 4 .   ? 3.597   -54.671 4.223  1.00 86.85  ? 530 HOH B O   1 ? 
HETATM 4946 O O   . HOH G 4 .   ? -28.140 -16.434 19.974 1.00 80.68  ? 531 HOH B O   1 ? 
HETATM 4947 O O   . HOH G 4 .   ? -25.965 -17.235 21.320 1.00 64.86  ? 532 HOH B O   1 ? 
HETATM 4948 O O   . HOH G 4 .   ? -22.060 -30.415 44.200 1.00 89.25  ? 533 HOH B O   1 ? 
HETATM 4949 O O   . HOH G 4 .   ? 7.116   -24.271 10.395 1.00 85.38  ? 534 HOH B O   1 ? 
HETATM 4950 O O   . HOH G 4 .   ? -18.921 -21.218 5.360  1.00 93.87  ? 535 HOH B O   1 ? 
HETATM 4951 O O   . HOH G 4 .   ? -16.720 -45.387 40.361 1.00 86.54  ? 536 HOH B O   1 ? 
HETATM 4952 O O   . HOH G 4 .   ? 8.880   -31.651 11.179 1.00 84.54  ? 537 HOH B O   1 ? 
HETATM 4953 O O   . HOH G 4 .   ? -20.007 -14.031 23.716 1.00 73.94  ? 538 HOH B O   1 ? 
HETATM 4954 O O   . HOH G 4 .   ? -22.840 -13.830 25.739 1.00 76.42  ? 539 HOH B O   1 ? 
HETATM 4955 O O   . HOH G 4 .   ? 4.599   -30.513 10.568 1.00 76.63  ? 540 HOH B O   1 ? 
HETATM 4956 O O   . HOH G 4 .   ? -2.116  -30.399 5.230  1.00 77.67  ? 541 HOH B O   1 ? 
HETATM 4957 O O   . HOH G 4 .   ? -12.648 -25.384 8.136  1.00 91.38  ? 542 HOH B O   1 ? 
HETATM 4958 O O   . HOH G 4 .   ? -6.090  -70.115 13.354 1.00 89.44  ? 543 HOH B O   1 ? 
HETATM 4959 O O   . HOH G 4 .   ? -18.852 -29.690 2.658  1.00 91.55  ? 544 HOH B O   1 ? 
HETATM 4960 O O   . HOH G 4 .   ? 6.025   -31.746 17.341 1.00 77.21  ? 545 HOH B O   1 ? 
HETATM 4961 O O   . HOH G 4 .   ? -13.323 -46.916 40.729 1.00 79.30  ? 546 HOH B O   1 ? 
HETATM 4962 O O   . HOH G 4 .   ? -1.903  -19.546 7.013  1.00 77.86  ? 547 HOH B O   1 ? 
HETATM 4963 O O   . HOH G 4 .   ? -6.425  -12.156 36.518 1.00 92.07  ? 548 HOH B O   1 ? 
HETATM 4964 O O   . HOH G 4 .   ? -2.550  -35.795 1.981  1.00 75.92  ? 549 HOH B O   1 ? 
HETATM 4965 O O   . HOH G 4 .   ? -32.724 -39.334 34.077 1.00 96.65  ? 550 HOH B O   1 ? 
HETATM 4966 O O   . HOH G 4 .   ? -22.245 -35.090 0.912  1.00 93.93  ? 551 HOH B O   1 ? 
HETATM 4967 O O   . HOH G 4 .   ? 7.707   -20.549 15.928 1.00 70.38  ? 552 HOH B O   1 ? 
HETATM 4968 O O   . HOH G 4 .   ? -20.812 -31.579 47.684 1.00 108.17 ? 553 HOH B O   1 ? 
HETATM 4969 O O   . HOH G 4 .   ? -28.813 -20.534 9.620  1.00 94.63  ? 554 HOH B O   1 ? 
HETATM 4970 O O   . HOH G 4 .   ? -2.816  -51.988 23.352 1.00 76.74  ? 555 HOH B O   1 ? 
HETATM 4971 O O   . HOH G 4 .   ? -4.205  -48.460 21.264 1.00 95.10  ? 556 HOH B O   1 ? 
HETATM 4972 O O   . HOH G 4 .   ? 2.230   -39.060 28.012 1.00 96.63  ? 557 HOH B O   1 ? 
HETATM 4973 O O   . HOH G 4 .   ? -5.721  -22.929 33.996 1.00 96.05  ? 558 HOH B O   1 ? 
HETATM 4974 O O   . HOH G 4 .   ? 5.821   -32.798 27.832 1.00 89.56  ? 559 HOH B O   1 ? 
HETATM 4975 O O   . HOH G 4 .   ? -24.976 -49.329 0.877  1.00 90.07  ? 560 HOH B O   1 ? 
HETATM 4976 O O   . HOH G 4 .   ? -10.214 -24.737 49.586 1.00 84.19  ? 561 HOH B O   1 ? 
HETATM 4977 O O   . HOH G 4 .   ? -10.992 -49.875 26.010 1.00 93.80  ? 562 HOH B O   1 ? 
# 
