data_8YMY
# 
_entry.id   8YMY 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YMY         pdb_00008ymy 10.2210/pdb8ymy/pdb 
WWPDB D_1300045974 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YMY 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          8YMV 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              aquarius@g.ecc.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Kiyohiko 
_pdbx_contact_author.name_last          Igarashi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5152-7177 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yamaguchi, S.' 1 ? 
'Sunagawa, N.'  2 ? 
'Tachioka, M.'  3 ? 
'Igarashi, K.'  4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Activity and X-ray crystal structure of candidate base catalyst mutant of glycoside hydrolase family 6 cellobiohydrolase' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yamaguchi, S.' 1 ? 
primary 'Sunagawa, N.'  2 ? 
primary 'Tachioka, M.'  3 ? 
primary 'Igarashi, K.'  4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Glucanase                                          38321.430 1   3.2.1.- 'C240S, R347K, C393S' ? ? 
2 branched    man 'beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose' 342.297   1   ?       ?                     ? ? 
3 branched    man 'beta-D-glucopyranose-(1-4)-beta-D-glucopyranose'  342.297   1   ?       ?                     ? ? 
4 non-polymer syn beta-D-glucopyranose                               180.156   1   ?       ?                     ? ? 
5 water       nat water                                              18.015    520 ?       ?                     ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLASV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGKSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGESDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLASV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGKSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGESDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 beta-D-glucopyranose BGC 
5 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   ALA n 
1 3   ASN n 
1 4   ASN n 
1 5   PRO n 
1 6   TRP n 
1 7   THR n 
1 8   GLY n 
1 9   PHE n 
1 10  GLN n 
1 11  ILE n 
1 12  PHE n 
1 13  LEU n 
1 14  SER n 
1 15  PRO n 
1 16  TYR n 
1 17  TYR n 
1 18  ALA n 
1 19  ASN n 
1 20  GLU n 
1 21  VAL n 
1 22  ALA n 
1 23  ALA n 
1 24  ALA n 
1 25  ALA n 
1 26  LYS n 
1 27  GLN n 
1 28  ILE n 
1 29  THR n 
1 30  ASP n 
1 31  PRO n 
1 32  THR n 
1 33  LEU n 
1 34  SER n 
1 35  SER n 
1 36  LYS n 
1 37  ALA n 
1 38  ALA n 
1 39  SER n 
1 40  VAL n 
1 41  ALA n 
1 42  ASN n 
1 43  ILE n 
1 44  PRO n 
1 45  THR n 
1 46  PHE n 
1 47  THR n 
1 48  TRP n 
1 49  LEU n 
1 50  ASP n 
1 51  SER n 
1 52  VAL n 
1 53  ALA n 
1 54  LYS n 
1 55  ILE n 
1 56  PRO n 
1 57  ASP n 
1 58  LEU n 
1 59  GLY n 
1 60  THR n 
1 61  TYR n 
1 62  LEU n 
1 63  ALA n 
1 64  SER n 
1 65  ALA n 
1 66  SER n 
1 67  ALA n 
1 68  LEU n 
1 69  GLY n 
1 70  LYS n 
1 71  SER n 
1 72  THR n 
1 73  GLY n 
1 74  THR n 
1 75  LYS n 
1 76  GLN n 
1 77  LEU n 
1 78  VAL n 
1 79  GLN n 
1 80  ILE n 
1 81  VAL n 
1 82  ILE n 
1 83  TYR n 
1 84  ASP n 
1 85  LEU n 
1 86  PRO n 
1 87  ASP n 
1 88  ARG n 
1 89  ASP n 
1 90  CYS n 
1 91  ALA n 
1 92  ALA n 
1 93  LYS n 
1 94  ALA n 
1 95  SER n 
1 96  ASN n 
1 97  GLY n 
1 98  GLU n 
1 99  PHE n 
1 100 SER n 
1 101 ILE n 
1 102 ALA n 
1 103 ASN n 
1 104 ASN n 
1 105 GLY n 
1 106 GLN n 
1 107 ALA n 
1 108 ASN n 
1 109 TYR n 
1 110 GLU n 
1 111 ASN n 
1 112 TYR n 
1 113 ILE n 
1 114 ASP n 
1 115 GLN n 
1 116 ILE n 
1 117 VAL n 
1 118 ALA n 
1 119 GLN n 
1 120 ILE n 
1 121 GLN n 
1 122 GLN n 
1 123 PHE n 
1 124 PRO n 
1 125 ASP n 
1 126 VAL n 
1 127 ARG n 
1 128 VAL n 
1 129 VAL n 
1 130 ALA n 
1 131 VAL n 
1 132 ILE n 
1 133 GLU n 
1 134 PRO n 
1 135 ASP n 
1 136 SER n 
1 137 LEU n 
1 138 ALA n 
1 139 ASN n 
1 140 LEU n 
1 141 VAL n 
1 142 THR n 
1 143 ASN n 
1 144 LEU n 
1 145 ASN n 
1 146 VAL n 
1 147 GLN n 
1 148 LYS n 
1 149 CYS n 
1 150 ALA n 
1 151 ASN n 
1 152 ALA n 
1 153 LYS n 
1 154 THR n 
1 155 THR n 
1 156 TYR n 
1 157 LEU n 
1 158 ALA n 
1 159 SER n 
1 160 VAL n 
1 161 ASN n 
1 162 TYR n 
1 163 ALA n 
1 164 LEU n 
1 165 THR n 
1 166 ASN n 
1 167 LEU n 
1 168 ALA n 
1 169 LYS n 
1 170 VAL n 
1 171 GLY n 
1 172 VAL n 
1 173 TYR n 
1 174 MET n 
1 175 TYR n 
1 176 MET n 
1 177 ASP n 
1 178 ALA n 
1 179 GLY n 
1 180 HIS n 
1 181 ALA n 
1 182 GLY n 
1 183 TRP n 
1 184 LEU n 
1 185 GLY n 
1 186 TRP n 
1 187 PRO n 
1 188 ALA n 
1 189 ASN n 
1 190 LEU n 
1 191 SER n 
1 192 PRO n 
1 193 ALA n 
1 194 ALA n 
1 195 GLN n 
1 196 LEU n 
1 197 PHE n 
1 198 THR n 
1 199 GLN n 
1 200 VAL n 
1 201 TRP n 
1 202 GLN n 
1 203 ASN n 
1 204 ALA n 
1 205 GLY n 
1 206 LYS n 
1 207 SER n 
1 208 PRO n 
1 209 PHE n 
1 210 ILE n 
1 211 LYS n 
1 212 GLY n 
1 213 LEU n 
1 214 ALA n 
1 215 THR n 
1 216 ASN n 
1 217 VAL n 
1 218 ALA n 
1 219 ASN n 
1 220 TYR n 
1 221 ASN n 
1 222 ALA n 
1 223 LEU n 
1 224 GLN n 
1 225 ALA n 
1 226 ALA n 
1 227 SER n 
1 228 PRO n 
1 229 ASP n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 GLN n 
1 234 GLY n 
1 235 ASN n 
1 236 PRO n 
1 237 ASN n 
1 238 TYR n 
1 239 ASP n 
1 240 GLU n 
1 241 ILE n 
1 242 HIS n 
1 243 TYR n 
1 244 ILE n 
1 245 ASN n 
1 246 ALA n 
1 247 LEU n 
1 248 ALA n 
1 249 PRO n 
1 250 LEU n 
1 251 LEU n 
1 252 GLN n 
1 253 GLN n 
1 254 ALA n 
1 255 GLY n 
1 256 TRP n 
1 257 ASP n 
1 258 ALA n 
1 259 THR n 
1 260 PHE n 
1 261 ILE n 
1 262 VAL n 
1 263 ASP n 
1 264 GLN n 
1 265 GLY n 
1 266 LYS n 
1 267 SER n 
1 268 GLY n 
1 269 VAL n 
1 270 GLN n 
1 271 ASN n 
1 272 ILE n 
1 273 ARG n 
1 274 GLN n 
1 275 GLN n 
1 276 TRP n 
1 277 GLY n 
1 278 ASP n 
1 279 TRP n 
1 280 CYS n 
1 281 ASN n 
1 282 ILE n 
1 283 LYS n 
1 284 GLY n 
1 285 ALA n 
1 286 GLY n 
1 287 PHE n 
1 288 GLY n 
1 289 THR n 
1 290 ARG n 
1 291 PRO n 
1 292 THR n 
1 293 THR n 
1 294 ASN n 
1 295 THR n 
1 296 GLY n 
1 297 SER n 
1 298 GLN n 
1 299 PHE n 
1 300 ILE n 
1 301 ASP n 
1 302 SER n 
1 303 ILE n 
1 304 VAL n 
1 305 TRP n 
1 306 VAL n 
1 307 LYS n 
1 308 PRO n 
1 309 GLY n 
1 310 GLY n 
1 311 GLU n 
1 312 SER n 
1 313 ASP n 
1 314 GLY n 
1 315 THR n 
1 316 SER n 
1 317 ASN n 
1 318 SER n 
1 319 SER n 
1 320 SER n 
1 321 PRO n 
1 322 ARG n 
1 323 TYR n 
1 324 ASP n 
1 325 SER n 
1 326 THR n 
1 327 CYS n 
1 328 SER n 
1 329 LEU n 
1 330 PRO n 
1 331 ASP n 
1 332 ALA n 
1 333 ALA n 
1 334 GLN n 
1 335 PRO n 
1 336 ALA n 
1 337 PRO n 
1 338 GLU n 
1 339 ALA n 
1 340 GLY n 
1 341 THR n 
1 342 TRP n 
1 343 PHE n 
1 344 GLN n 
1 345 ALA n 
1 346 TYR n 
1 347 PHE n 
1 348 GLN n 
1 349 THR n 
1 350 LEU n 
1 351 VAL n 
1 352 SER n 
1 353 ALA n 
1 354 ALA n 
1 355 ASN n 
1 356 PRO n 
1 357 PRO n 
1 358 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   358 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 cel6A 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    K-3 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Phanerodontia chrysosporium' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2822231 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               KM71H 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pPICZalpha 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_branch.entity_id 
_pdbx_entity_branch.type 
2 oligosaccharide 
3 oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 2 DGlcpb1-4DGlcpa1-ROH                                       'Glycam Condensed Sequence' GMML       1.0   
2 2 'WURCS=2.0/2,2,1/[a2122h-1a_1-5][a2122h-1b_1-5]/1-2/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 2 '[][a-D-Glcp]{[(4+1)][b-D-Glcp]{}}'                        LINUCS                      PDB-CARE   ?     
4 3 DGlcpb1-4DGlcpb1-ROH                                       'Glycam Condensed Sequence' GMML       1.0   
5 3 'WURCS=2.0/1,2,1/[a2122h-1b_1-5]/1-1/a4-b1'                WURCS                       PDB2Glycan 1.1.0 
6 3 '[][b-D-Glcp]{[(4+1)][b-D-Glcp]{}}'                        LINUCS                      PDB-CARE   ?     
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 2 2 BGC C1 O1 1 GLC O4 HO4 sing ? 
2 2 2 BGC C1 O1 1 BGC O4 HO4 sing ? 
3 3 2 BGC C1 O1 1 BGC O4 HO4 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE               ?                                     'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE              ?                                     'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE            ?                                     'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'       ?                                     'C4 H7 N O4'     133.103 
BGC 'D-saccharide, beta linking'  . beta-D-glucopyranose  'beta-D-glucose; D-glucose; glucose'  'C6 H12 O6'      180.156 
CYS 'L-peptide linking'           y CYSTEINE              ?                                     'C3 H7 N O2 S'   121.158 
GLC 'D-saccharide, alpha linking' . alpha-D-glucopyranose 'alpha-D-glucose; D-glucose; glucose' 'C6 H12 O6'      180.156 
GLN 'L-peptide linking'           y GLUTAMINE             ?                                     'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'       ?                                     'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE               ?                                     'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE             ?                                     'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                   . WATER                 ?                                     'H2 O'           18.015  
ILE 'L-peptide linking'           y ISOLEUCINE            ?                                     'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE               ?                                     'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                ?                                     'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'           y METHIONINE            ?                                     'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking'           y PHENYLALANINE         ?                                     'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE               ?                                     'C5 H9 N O2'     115.130 
SER 'L-peptide linking'           y SERINE                ?                                     'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE             ?                                     'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN            ?                                     'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE              ?                                     'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                ?                                     'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BGC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpb            
BGC 'COMMON NAME'                         GMML     1.0 b-D-glucopyranose 
BGC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Glcp          
BGC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Glc               
GLC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpa            
GLC 'COMMON NAME'                         GMML     1.0 a-D-glucopyranose 
GLC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-D-Glcp          
GLC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Glc               
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   82  82  SER SER A . n 
A 1 2   ALA 2   83  83  ALA ALA A . n 
A 1 3   ASN 3   84  84  ASN ASN A . n 
A 1 4   ASN 4   85  85  ASN ASN A . n 
A 1 5   PRO 5   86  86  PRO PRO A . n 
A 1 6   TRP 6   87  87  TRP TRP A . n 
A 1 7   THR 7   88  88  THR THR A . n 
A 1 8   GLY 8   89  89  GLY GLY A . n 
A 1 9   PHE 9   90  90  PHE PHE A . n 
A 1 10  GLN 10  91  91  GLN GLN A . n 
A 1 11  ILE 11  92  92  ILE ILE A . n 
A 1 12  PHE 12  93  93  PHE PHE A . n 
A 1 13  LEU 13  94  94  LEU LEU A . n 
A 1 14  SER 14  95  95  SER SER A . n 
A 1 15  PRO 15  96  96  PRO PRO A . n 
A 1 16  TYR 16  97  97  TYR TYR A . n 
A 1 17  TYR 17  98  98  TYR TYR A . n 
A 1 18  ALA 18  99  99  ALA ALA A . n 
A 1 19  ASN 19  100 100 ASN ASN A . n 
A 1 20  GLU 20  101 101 GLU GLU A . n 
A 1 21  VAL 21  102 102 VAL VAL A . n 
A 1 22  ALA 22  103 103 ALA ALA A . n 
A 1 23  ALA 23  104 104 ALA ALA A . n 
A 1 24  ALA 24  105 105 ALA ALA A . n 
A 1 25  ALA 25  106 106 ALA ALA A . n 
A 1 26  LYS 26  107 107 LYS LYS A . n 
A 1 27  GLN 27  108 108 GLN GLN A . n 
A 1 28  ILE 28  109 109 ILE ILE A . n 
A 1 29  THR 29  110 110 THR THR A . n 
A 1 30  ASP 30  111 111 ASP ASP A . n 
A 1 31  PRO 31  112 112 PRO PRO A . n 
A 1 32  THR 32  113 113 THR THR A . n 
A 1 33  LEU 33  114 114 LEU LEU A . n 
A 1 34  SER 34  115 115 SER SER A . n 
A 1 35  SER 35  116 116 SER SER A . n 
A 1 36  LYS 36  117 117 LYS LYS A . n 
A 1 37  ALA 37  118 118 ALA ALA A . n 
A 1 38  ALA 38  119 119 ALA ALA A . n 
A 1 39  SER 39  120 120 SER SER A . n 
A 1 40  VAL 40  121 121 VAL VAL A . n 
A 1 41  ALA 41  122 122 ALA ALA A . n 
A 1 42  ASN 42  123 123 ASN ASN A . n 
A 1 43  ILE 43  124 124 ILE ILE A . n 
A 1 44  PRO 44  125 125 PRO PRO A . n 
A 1 45  THR 45  126 126 THR THR A . n 
A 1 46  PHE 46  127 127 PHE PHE A . n 
A 1 47  THR 47  128 128 THR THR A . n 
A 1 48  TRP 48  129 129 TRP TRP A . n 
A 1 49  LEU 49  130 130 LEU LEU A . n 
A 1 50  ASP 50  131 131 ASP ASP A . n 
A 1 51  SER 51  132 132 SER SER A . n 
A 1 52  VAL 52  133 133 VAL VAL A . n 
A 1 53  ALA 53  134 134 ALA ALA A . n 
A 1 54  LYS 54  135 135 LYS LYS A . n 
A 1 55  ILE 55  136 136 ILE ILE A . n 
A 1 56  PRO 56  137 137 PRO PRO A . n 
A 1 57  ASP 57  138 138 ASP ASP A . n 
A 1 58  LEU 58  139 139 LEU LEU A . n 
A 1 59  GLY 59  140 140 GLY GLY A . n 
A 1 60  THR 60  141 141 THR THR A . n 
A 1 61  TYR 61  142 142 TYR TYR A . n 
A 1 62  LEU 62  143 143 LEU LEU A . n 
A 1 63  ALA 63  144 144 ALA ALA A . n 
A 1 64  SER 64  145 145 SER SER A . n 
A 1 65  ALA 65  146 146 ALA ALA A . n 
A 1 66  SER 66  147 147 SER SER A . n 
A 1 67  ALA 67  148 148 ALA ALA A . n 
A 1 68  LEU 68  149 149 LEU LEU A . n 
A 1 69  GLY 69  150 150 GLY GLY A . n 
A 1 70  LYS 70  151 151 LYS LYS A . n 
A 1 71  SER 71  152 152 SER SER A . n 
A 1 72  THR 72  153 153 THR THR A . n 
A 1 73  GLY 73  154 154 GLY GLY A . n 
A 1 74  THR 74  155 155 THR THR A . n 
A 1 75  LYS 75  156 156 LYS LYS A . n 
A 1 76  GLN 76  157 157 GLN GLN A . n 
A 1 77  LEU 77  158 158 LEU LEU A . n 
A 1 78  VAL 78  159 159 VAL VAL A . n 
A 1 79  GLN 79  160 160 GLN GLN A . n 
A 1 80  ILE 80  161 161 ILE ILE A . n 
A 1 81  VAL 81  162 162 VAL VAL A . n 
A 1 82  ILE 82  163 163 ILE ILE A . n 
A 1 83  TYR 83  164 164 TYR TYR A . n 
A 1 84  ASP 84  165 165 ASP ASP A . n 
A 1 85  LEU 85  166 166 LEU LEU A . n 
A 1 86  PRO 86  167 167 PRO PRO A . n 
A 1 87  ASP 87  168 168 ASP ASP A . n 
A 1 88  ARG 88  169 169 ARG ARG A . n 
A 1 89  ASP 89  170 170 ASP ASP A . n 
A 1 90  CYS 90  171 171 CYS CYS A . n 
A 1 91  ALA 91  172 172 ALA ALA A . n 
A 1 92  ALA 92  173 173 ALA ALA A . n 
A 1 93  LYS 93  174 174 LYS LYS A . n 
A 1 94  ALA 94  175 175 ALA ALA A . n 
A 1 95  SER 95  176 176 SER SER A . n 
A 1 96  ASN 96  177 177 ASN ASN A . n 
A 1 97  GLY 97  178 178 GLY GLY A . n 
A 1 98  GLU 98  179 179 GLU GLU A . n 
A 1 99  PHE 99  180 180 PHE PHE A . n 
A 1 100 SER 100 181 181 SER SER A . n 
A 1 101 ILE 101 182 182 ILE ILE A . n 
A 1 102 ALA 102 183 183 ALA ALA A . n 
A 1 103 ASN 103 184 184 ASN ASN A . n 
A 1 104 ASN 104 185 185 ASN ASN A . n 
A 1 105 GLY 105 186 186 GLY GLY A . n 
A 1 106 GLN 106 187 187 GLN GLN A . n 
A 1 107 ALA 107 188 188 ALA ALA A . n 
A 1 108 ASN 108 189 189 ASN ASN A . n 
A 1 109 TYR 109 190 190 TYR TYR A . n 
A 1 110 GLU 110 191 191 GLU GLU A . n 
A 1 111 ASN 111 192 192 ASN ASN A . n 
A 1 112 TYR 112 193 193 TYR TYR A . n 
A 1 113 ILE 113 194 194 ILE ILE A . n 
A 1 114 ASP 114 195 195 ASP ASP A . n 
A 1 115 GLN 115 196 196 GLN GLN A . n 
A 1 116 ILE 116 197 197 ILE ILE A . n 
A 1 117 VAL 117 198 198 VAL VAL A . n 
A 1 118 ALA 118 199 199 ALA ALA A . n 
A 1 119 GLN 119 200 200 GLN GLN A . n 
A 1 120 ILE 120 201 201 ILE ILE A . n 
A 1 121 GLN 121 202 202 GLN GLN A . n 
A 1 122 GLN 122 203 203 GLN GLN A . n 
A 1 123 PHE 123 204 204 PHE PHE A . n 
A 1 124 PRO 124 205 205 PRO PRO A . n 
A 1 125 ASP 125 206 206 ASP ASP A . n 
A 1 126 VAL 126 207 207 VAL VAL A . n 
A 1 127 ARG 127 208 208 ARG ARG A . n 
A 1 128 VAL 128 209 209 VAL VAL A . n 
A 1 129 VAL 129 210 210 VAL VAL A . n 
A 1 130 ALA 130 211 211 ALA ALA A . n 
A 1 131 VAL 131 212 212 VAL VAL A . n 
A 1 132 ILE 132 213 213 ILE ILE A . n 
A 1 133 GLU 133 214 214 GLU GLU A . n 
A 1 134 PRO 134 215 215 PRO PRO A . n 
A 1 135 ASP 135 216 216 ASP ASP A . n 
A 1 136 SER 136 217 217 SER SER A . n 
A 1 137 LEU 137 218 218 LEU LEU A . n 
A 1 138 ALA 138 219 219 ALA ALA A . n 
A 1 139 ASN 139 220 220 ASN ASN A . n 
A 1 140 LEU 140 221 221 LEU LEU A . n 
A 1 141 VAL 141 222 222 VAL VAL A . n 
A 1 142 THR 142 223 223 THR THR A . n 
A 1 143 ASN 143 224 224 ASN ASN A . n 
A 1 144 LEU 144 225 225 LEU LEU A . n 
A 1 145 ASN 145 226 226 ASN ASN A . n 
A 1 146 VAL 146 227 227 VAL VAL A . n 
A 1 147 GLN 147 228 228 GLN GLN A . n 
A 1 148 LYS 148 229 229 LYS LYS A . n 
A 1 149 CYS 149 230 230 CYS CYS A . n 
A 1 150 ALA 150 231 231 ALA ALA A . n 
A 1 151 ASN 151 232 232 ASN ASN A . n 
A 1 152 ALA 152 233 233 ALA ALA A . n 
A 1 153 LYS 153 234 234 LYS LYS A . n 
A 1 154 THR 154 235 235 THR THR A . n 
A 1 155 THR 155 236 236 THR THR A . n 
A 1 156 TYR 156 237 237 TYR TYR A . n 
A 1 157 LEU 157 238 238 LEU LEU A . n 
A 1 158 ALA 158 239 239 ALA ALA A . n 
A 1 159 SER 159 240 240 SER SER A . n 
A 1 160 VAL 160 241 241 VAL VAL A . n 
A 1 161 ASN 161 242 242 ASN ASN A . n 
A 1 162 TYR 162 243 243 TYR TYR A . n 
A 1 163 ALA 163 244 244 ALA ALA A . n 
A 1 164 LEU 164 245 245 LEU LEU A . n 
A 1 165 THR 165 246 246 THR THR A . n 
A 1 166 ASN 166 247 247 ASN ASN A . n 
A 1 167 LEU 167 248 248 LEU LEU A . n 
A 1 168 ALA 168 249 249 ALA ALA A . n 
A 1 169 LYS 169 250 250 LYS LYS A . n 
A 1 170 VAL 170 251 251 VAL VAL A . n 
A 1 171 GLY 171 252 252 GLY GLY A . n 
A 1 172 VAL 172 253 253 VAL VAL A . n 
A 1 173 TYR 173 254 254 TYR TYR A . n 
A 1 174 MET 174 255 255 MET MET A . n 
A 1 175 TYR 175 256 256 TYR TYR A . n 
A 1 176 MET 176 257 257 MET MET A . n 
A 1 177 ASP 177 258 258 ASP ASP A . n 
A 1 178 ALA 178 259 259 ALA ALA A . n 
A 1 179 GLY 179 260 260 GLY GLY A . n 
A 1 180 HIS 180 261 261 HIS HIS A . n 
A 1 181 ALA 181 262 262 ALA ALA A . n 
A 1 182 GLY 182 263 263 GLY GLY A . n 
A 1 183 TRP 183 264 264 TRP TRP A . n 
A 1 184 LEU 184 265 265 LEU LEU A . n 
A 1 185 GLY 185 266 266 GLY GLY A . n 
A 1 186 TRP 186 267 267 TRP TRP A . n 
A 1 187 PRO 187 268 268 PRO PRO A . n 
A 1 188 ALA 188 269 269 ALA ALA A . n 
A 1 189 ASN 189 270 270 ASN ASN A . n 
A 1 190 LEU 190 271 271 LEU LEU A . n 
A 1 191 SER 191 272 272 SER SER A . n 
A 1 192 PRO 192 273 273 PRO PRO A . n 
A 1 193 ALA 193 274 274 ALA ALA A . n 
A 1 194 ALA 194 275 275 ALA ALA A . n 
A 1 195 GLN 195 276 276 GLN GLN A . n 
A 1 196 LEU 196 277 277 LEU LEU A . n 
A 1 197 PHE 197 278 278 PHE PHE A . n 
A 1 198 THR 198 279 279 THR THR A . n 
A 1 199 GLN 199 280 280 GLN GLN A . n 
A 1 200 VAL 200 281 281 VAL VAL A . n 
A 1 201 TRP 201 282 282 TRP TRP A . n 
A 1 202 GLN 202 283 283 GLN GLN A . n 
A 1 203 ASN 203 284 284 ASN ASN A . n 
A 1 204 ALA 204 285 285 ALA ALA A . n 
A 1 205 GLY 205 286 286 GLY GLY A . n 
A 1 206 LYS 206 287 287 LYS LYS A . n 
A 1 207 SER 207 288 288 SER SER A . n 
A 1 208 PRO 208 289 289 PRO PRO A . n 
A 1 209 PHE 209 290 290 PHE PHE A . n 
A 1 210 ILE 210 291 291 ILE ILE A . n 
A 1 211 LYS 211 292 292 LYS LYS A . n 
A 1 212 GLY 212 293 293 GLY GLY A . n 
A 1 213 LEU 213 294 294 LEU LEU A . n 
A 1 214 ALA 214 295 295 ALA ALA A . n 
A 1 215 THR 215 296 296 THR THR A . n 
A 1 216 ASN 216 297 297 ASN ASN A . n 
A 1 217 VAL 217 298 298 VAL VAL A . n 
A 1 218 ALA 218 299 299 ALA ALA A . n 
A 1 219 ASN 219 300 300 ASN ASN A . n 
A 1 220 TYR 220 301 301 TYR TYR A . n 
A 1 221 ASN 221 302 302 ASN ASN A . n 
A 1 222 ALA 222 303 303 ALA ALA A . n 
A 1 223 LEU 223 304 304 LEU LEU A . n 
A 1 224 GLN 224 305 305 GLN GLN A . n 
A 1 225 ALA 225 306 306 ALA ALA A . n 
A 1 226 ALA 226 307 307 ALA ALA A . n 
A 1 227 SER 227 308 308 SER SER A . n 
A 1 228 PRO 228 309 309 PRO PRO A . n 
A 1 229 ASP 229 310 310 ASP ASP A . n 
A 1 230 PRO 230 311 311 PRO PRO A . n 
A 1 231 ILE 231 312 312 ILE ILE A . n 
A 1 232 THR 232 313 313 THR THR A . n 
A 1 233 GLN 233 314 314 GLN GLN A . n 
A 1 234 GLY 234 315 315 GLY GLY A . n 
A 1 235 ASN 235 316 316 ASN ASN A . n 
A 1 236 PRO 236 317 317 PRO PRO A . n 
A 1 237 ASN 237 318 318 ASN ASN A . n 
A 1 238 TYR 238 319 319 TYR TYR A . n 
A 1 239 ASP 239 320 320 ASP ASP A . n 
A 1 240 GLU 240 321 321 GLU GLU A . n 
A 1 241 ILE 241 322 322 ILE ILE A . n 
A 1 242 HIS 242 323 323 HIS HIS A . n 
A 1 243 TYR 243 324 324 TYR TYR A . n 
A 1 244 ILE 244 325 325 ILE ILE A . n 
A 1 245 ASN 245 326 326 ASN ASN A . n 
A 1 246 ALA 246 327 327 ALA ALA A . n 
A 1 247 LEU 247 328 328 LEU LEU A . n 
A 1 248 ALA 248 329 329 ALA ALA A . n 
A 1 249 PRO 249 330 330 PRO PRO A . n 
A 1 250 LEU 250 331 331 LEU LEU A . n 
A 1 251 LEU 251 332 332 LEU LEU A . n 
A 1 252 GLN 252 333 333 GLN GLN A . n 
A 1 253 GLN 253 334 334 GLN GLN A . n 
A 1 254 ALA 254 335 335 ALA ALA A . n 
A 1 255 GLY 255 336 336 GLY GLY A . n 
A 1 256 TRP 256 337 337 TRP TRP A . n 
A 1 257 ASP 257 338 338 ASP ASP A . n 
A 1 258 ALA 258 339 339 ALA ALA A . n 
A 1 259 THR 259 340 340 THR THR A . n 
A 1 260 PHE 260 341 341 PHE PHE A . n 
A 1 261 ILE 261 342 342 ILE ILE A . n 
A 1 262 VAL 262 343 343 VAL VAL A . n 
A 1 263 ASP 263 344 344 ASP ASP A . n 
A 1 264 GLN 264 345 345 GLN GLN A . n 
A 1 265 GLY 265 346 346 GLY GLY A . n 
A 1 266 LYS 266 347 347 LYS LYS A . n 
A 1 267 SER 267 348 348 SER SER A . n 
A 1 268 GLY 268 349 349 GLY GLY A . n 
A 1 269 VAL 269 350 350 VAL VAL A . n 
A 1 270 GLN 270 351 351 GLN GLN A . n 
A 1 271 ASN 271 352 352 ASN ASN A . n 
A 1 272 ILE 272 353 353 ILE ILE A . n 
A 1 273 ARG 273 354 354 ARG ARG A . n 
A 1 274 GLN 274 355 355 GLN GLN A . n 
A 1 275 GLN 275 356 356 GLN GLN A . n 
A 1 276 TRP 276 357 357 TRP TRP A . n 
A 1 277 GLY 277 358 358 GLY GLY A . n 
A 1 278 ASP 278 359 359 ASP ASP A . n 
A 1 279 TRP 279 360 360 TRP TRP A . n 
A 1 280 CYS 280 361 361 CYS CYS A . n 
A 1 281 ASN 281 362 362 ASN ASN A . n 
A 1 282 ILE 282 363 363 ILE ILE A . n 
A 1 283 LYS 283 364 364 LYS LYS A . n 
A 1 284 GLY 284 365 365 GLY GLY A . n 
A 1 285 ALA 285 366 366 ALA ALA A . n 
A 1 286 GLY 286 367 367 GLY GLY A . n 
A 1 287 PHE 287 368 368 PHE PHE A . n 
A 1 288 GLY 288 369 369 GLY GLY A . n 
A 1 289 THR 289 370 370 THR THR A . n 
A 1 290 ARG 290 371 371 ARG ARG A . n 
A 1 291 PRO 291 372 372 PRO PRO A . n 
A 1 292 THR 292 373 373 THR THR A . n 
A 1 293 THR 293 374 374 THR THR A . n 
A 1 294 ASN 294 375 375 ASN ASN A . n 
A 1 295 THR 295 376 376 THR THR A . n 
A 1 296 GLY 296 377 377 GLY GLY A . n 
A 1 297 SER 297 378 378 SER SER A . n 
A 1 298 GLN 298 379 379 GLN GLN A . n 
A 1 299 PHE 299 380 380 PHE PHE A . n 
A 1 300 ILE 300 381 381 ILE ILE A . n 
A 1 301 ASP 301 382 382 ASP ASP A . n 
A 1 302 SER 302 383 383 SER SER A . n 
A 1 303 ILE 303 384 384 ILE ILE A . n 
A 1 304 VAL 304 385 385 VAL VAL A . n 
A 1 305 TRP 305 386 386 TRP TRP A . n 
A 1 306 VAL 306 387 387 VAL VAL A . n 
A 1 307 LYS 307 388 388 LYS LYS A . n 
A 1 308 PRO 308 389 389 PRO PRO A . n 
A 1 309 GLY 309 390 390 GLY GLY A . n 
A 1 310 GLY 310 391 391 GLY GLY A . n 
A 1 311 GLU 311 392 392 GLU GLU A . n 
A 1 312 SER 312 393 393 SER SER A . n 
A 1 313 ASP 313 394 394 ASP ASP A . n 
A 1 314 GLY 314 395 395 GLY GLY A . n 
A 1 315 THR 315 396 396 THR THR A . n 
A 1 316 SER 316 397 397 SER SER A . n 
A 1 317 ASN 317 398 398 ASN ASN A . n 
A 1 318 SER 318 399 399 SER SER A . n 
A 1 319 SER 319 400 400 SER SER A . n 
A 1 320 SER 320 401 401 SER SER A . n 
A 1 321 PRO 321 402 402 PRO PRO A . n 
A 1 322 ARG 322 403 403 ARG ARG A . n 
A 1 323 TYR 323 404 404 TYR TYR A . n 
A 1 324 ASP 324 405 405 ASP ASP A . n 
A 1 325 SER 325 406 406 SER SER A . n 
A 1 326 THR 326 407 407 THR THR A . n 
A 1 327 CYS 327 408 408 CYS CYS A . n 
A 1 328 SER 328 409 409 SER SER A . n 
A 1 329 LEU 329 410 410 LEU LEU A . n 
A 1 330 PRO 330 411 411 PRO PRO A . n 
A 1 331 ASP 331 412 412 ASP ASP A . n 
A 1 332 ALA 332 413 413 ALA ALA A . n 
A 1 333 ALA 333 414 414 ALA ALA A . n 
A 1 334 GLN 334 415 415 GLN GLN A . n 
A 1 335 PRO 335 416 416 PRO PRO A . n 
A 1 336 ALA 336 417 417 ALA ALA A . n 
A 1 337 PRO 337 418 418 PRO PRO A . n 
A 1 338 GLU 338 419 419 GLU GLU A . n 
A 1 339 ALA 339 420 420 ALA ALA A . n 
A 1 340 GLY 340 421 421 GLY GLY A . n 
A 1 341 THR 341 422 422 THR THR A . n 
A 1 342 TRP 342 423 423 TRP TRP A . n 
A 1 343 PHE 343 424 424 PHE PHE A . n 
A 1 344 GLN 344 425 425 GLN GLN A . n 
A 1 345 ALA 345 426 426 ALA ALA A . n 
A 1 346 TYR 346 427 427 TYR TYR A . n 
A 1 347 PHE 347 428 428 PHE PHE A . n 
A 1 348 GLN 348 429 429 GLN GLN A . n 
A 1 349 THR 349 430 430 THR THR A . n 
A 1 350 LEU 350 431 431 LEU LEU A . n 
A 1 351 VAL 351 432 432 VAL VAL A . n 
A 1 352 SER 352 433 433 SER SER A . n 
A 1 353 ALA 353 434 434 ALA ALA A . n 
A 1 354 ALA 354 435 435 ALA ALA A . n 
A 1 355 ASN 355 436 436 ASN ASN A . n 
A 1 356 PRO 356 437 437 PRO PRO A . n 
A 1 357 PRO 357 438 438 PRO PRO A . n 
A 1 358 LEU 358 439 439 LEU LEU A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
B 2 GLC 1 B GLC 1 A GLC 502 y 
B 2 BGC 1 B BGC 1 A BGC 502 y 
B 2 BGC 2 B BGC 2 A BGC 501 n 
C 3 BGC 1 C BGC 1 A BGC 504 n 
C 3 BGC 2 C BGC 2 A BGC 505 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 BGC ? ? BGC ? ? 'SUBJECT OF INVESTIGATION' ? 
2 GLC ? ? GLC ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 BGC 1   501  503 BGC BGC A . 
E 5 HOH 1   601  572 HOH HOH A . 
E 5 HOH 2   602  574 HOH HOH A . 
E 5 HOH 3   603  379 HOH HOH A . 
E 5 HOH 4   604  109 HOH HOH A . 
E 5 HOH 5   605  480 HOH HOH A . 
E 5 HOH 6   606  136 HOH HOH A . 
E 5 HOH 7   607  1   HOH HOH A . 
E 5 HOH 8   608  179 HOH HOH A . 
E 5 HOH 9   609  172 HOH HOH A . 
E 5 HOH 10  610  569 HOH HOH A . 
E 5 HOH 11  611  202 HOH HOH A . 
E 5 HOH 12  612  84  HOH HOH A . 
E 5 HOH 13  613  72  HOH HOH A . 
E 5 HOH 14  614  395 HOH HOH A . 
E 5 HOH 15  615  320 HOH HOH A . 
E 5 HOH 16  616  528 HOH HOH A . 
E 5 HOH 17  617  122 HOH HOH A . 
E 5 HOH 18  618  45  HOH HOH A . 
E 5 HOH 19  619  201 HOH HOH A . 
E 5 HOH 20  620  149 HOH HOH A . 
E 5 HOH 21  621  154 HOH HOH A . 
E 5 HOH 22  622  198 HOH HOH A . 
E 5 HOH 23  623  493 HOH HOH A . 
E 5 HOH 24  624  524 HOH HOH A . 
E 5 HOH 25  625  512 HOH HOH A . 
E 5 HOH 26  626  115 HOH HOH A . 
E 5 HOH 27  627  464 HOH HOH A . 
E 5 HOH 28  628  36  HOH HOH A . 
E 5 HOH 29  629  367 HOH HOH A . 
E 5 HOH 30  630  489 HOH HOH A . 
E 5 HOH 31  631  284 HOH HOH A . 
E 5 HOH 32  632  290 HOH HOH A . 
E 5 HOH 33  633  256 HOH HOH A . 
E 5 HOH 34  634  406 HOH HOH A . 
E 5 HOH 35  635  361 HOH HOH A . 
E 5 HOH 36  636  383 HOH HOH A . 
E 5 HOH 37  637  568 HOH HOH A . 
E 5 HOH 38  638  127 HOH HOH A . 
E 5 HOH 39  639  193 HOH HOH A . 
E 5 HOH 40  640  571 HOH HOH A . 
E 5 HOH 41  641  90  HOH HOH A . 
E 5 HOH 42  642  73  HOH HOH A . 
E 5 HOH 43  643  116 HOH HOH A . 
E 5 HOH 44  644  551 HOH HOH A . 
E 5 HOH 45  645  29  HOH HOH A . 
E 5 HOH 46  646  308 HOH HOH A . 
E 5 HOH 47  647  295 HOH HOH A . 
E 5 HOH 48  648  408 HOH HOH A . 
E 5 HOH 49  649  328 HOH HOH A . 
E 5 HOH 50  650  419 HOH HOH A . 
E 5 HOH 51  651  101 HOH HOH A . 
E 5 HOH 52  652  514 HOH HOH A . 
E 5 HOH 53  653  517 HOH HOH A . 
E 5 HOH 54  654  239 HOH HOH A . 
E 5 HOH 55  655  244 HOH HOH A . 
E 5 HOH 56  656  252 HOH HOH A . 
E 5 HOH 57  657  258 HOH HOH A . 
E 5 HOH 58  658  500 HOH HOH A . 
E 5 HOH 59  659  25  HOH HOH A . 
E 5 HOH 60  660  119 HOH HOH A . 
E 5 HOH 61  661  205 HOH HOH A . 
E 5 HOH 62  662  229 HOH HOH A . 
E 5 HOH 63  663  474 HOH HOH A . 
E 5 HOH 64  664  174 HOH HOH A . 
E 5 HOH 65  665  78  HOH HOH A . 
E 5 HOH 66  666  131 HOH HOH A . 
E 5 HOH 67  667  114 HOH HOH A . 
E 5 HOH 68  668  42  HOH HOH A . 
E 5 HOH 69  669  325 HOH HOH A . 
E 5 HOH 70  670  38  HOH HOH A . 
E 5 HOH 71  671  49  HOH HOH A . 
E 5 HOH 72  672  318 HOH HOH A . 
E 5 HOH 73  673  92  HOH HOH A . 
E 5 HOH 74  674  14  HOH HOH A . 
E 5 HOH 75  675  102 HOH HOH A . 
E 5 HOH 76  676  187 HOH HOH A . 
E 5 HOH 77  677  140 HOH HOH A . 
E 5 HOH 78  678  550 HOH HOH A . 
E 5 HOH 79  679  215 HOH HOH A . 
E 5 HOH 80  680  345 HOH HOH A . 
E 5 HOH 81  681  488 HOH HOH A . 
E 5 HOH 82  682  168 HOH HOH A . 
E 5 HOH 83  683  88  HOH HOH A . 
E 5 HOH 84  684  241 HOH HOH A . 
E 5 HOH 85  685  501 HOH HOH A . 
E 5 HOH 86  686  428 HOH HOH A . 
E 5 HOH 87  687  363 HOH HOH A . 
E 5 HOH 88  688  199 HOH HOH A . 
E 5 HOH 89  689  123 HOH HOH A . 
E 5 HOH 90  690  531 HOH HOH A . 
E 5 HOH 91  691  32  HOH HOH A . 
E 5 HOH 92  692  146 HOH HOH A . 
E 5 HOH 93  693  3   HOH HOH A . 
E 5 HOH 94  694  335 HOH HOH A . 
E 5 HOH 95  695  157 HOH HOH A . 
E 5 HOH 96  696  214 HOH HOH A . 
E 5 HOH 97  697  348 HOH HOH A . 
E 5 HOH 98  698  364 HOH HOH A . 
E 5 HOH 99  699  71  HOH HOH A . 
E 5 HOH 100 700  26  HOH HOH A . 
E 5 HOH 101 701  155 HOH HOH A . 
E 5 HOH 102 702  20  HOH HOH A . 
E 5 HOH 103 703  186 HOH HOH A . 
E 5 HOH 104 704  306 HOH HOH A . 
E 5 HOH 105 705  96  HOH HOH A . 
E 5 HOH 106 706  547 HOH HOH A . 
E 5 HOH 107 707  70  HOH HOH A . 
E 5 HOH 108 708  162 HOH HOH A . 
E 5 HOH 109 709  104 HOH HOH A . 
E 5 HOH 110 710  30  HOH HOH A . 
E 5 HOH 111 711  217 HOH HOH A . 
E 5 HOH 112 712  427 HOH HOH A . 
E 5 HOH 113 713  21  HOH HOH A . 
E 5 HOH 114 714  15  HOH HOH A . 
E 5 HOH 115 715  536 HOH HOH A . 
E 5 HOH 116 716  6   HOH HOH A . 
E 5 HOH 117 717  180 HOH HOH A . 
E 5 HOH 118 718  8   HOH HOH A . 
E 5 HOH 119 719  273 HOH HOH A . 
E 5 HOH 120 720  479 HOH HOH A . 
E 5 HOH 121 721  52  HOH HOH A . 
E 5 HOH 122 722  55  HOH HOH A . 
E 5 HOH 123 723  111 HOH HOH A . 
E 5 HOH 124 724  43  HOH HOH A . 
E 5 HOH 125 725  228 HOH HOH A . 
E 5 HOH 126 726  219 HOH HOH A . 
E 5 HOH 127 727  211 HOH HOH A . 
E 5 HOH 128 728  98  HOH HOH A . 
E 5 HOH 129 729  19  HOH HOH A . 
E 5 HOH 130 730  110 HOH HOH A . 
E 5 HOH 131 731  269 HOH HOH A . 
E 5 HOH 132 732  253 HOH HOH A . 
E 5 HOH 133 733  542 HOH HOH A . 
E 5 HOH 134 734  34  HOH HOH A . 
E 5 HOH 135 735  372 HOH HOH A . 
E 5 HOH 136 736  137 HOH HOH A . 
E 5 HOH 137 737  89  HOH HOH A . 
E 5 HOH 138 738  327 HOH HOH A . 
E 5 HOH 139 739  386 HOH HOH A . 
E 5 HOH 140 740  79  HOH HOH A . 
E 5 HOH 141 741  398 HOH HOH A . 
E 5 HOH 142 742  314 HOH HOH A . 
E 5 HOH 143 743  276 HOH HOH A . 
E 5 HOH 144 744  303 HOH HOH A . 
E 5 HOH 145 745  24  HOH HOH A . 
E 5 HOH 146 746  384 HOH HOH A . 
E 5 HOH 147 747  23  HOH HOH A . 
E 5 HOH 148 748  317 HOH HOH A . 
E 5 HOH 149 749  103 HOH HOH A . 
E 5 HOH 150 750  64  HOH HOH A . 
E 5 HOH 151 751  360 HOH HOH A . 
E 5 HOH 152 752  234 HOH HOH A . 
E 5 HOH 153 753  445 HOH HOH A . 
E 5 HOH 154 754  152 HOH HOH A . 
E 5 HOH 155 755  486 HOH HOH A . 
E 5 HOH 156 756  315 HOH HOH A . 
E 5 HOH 157 757  265 HOH HOH A . 
E 5 HOH 158 758  46  HOH HOH A . 
E 5 HOH 159 759  80  HOH HOH A . 
E 5 HOH 160 760  117 HOH HOH A . 
E 5 HOH 161 761  566 HOH HOH A . 
E 5 HOH 162 762  212 HOH HOH A . 
E 5 HOH 163 763  549 HOH HOH A . 
E 5 HOH 164 764  240 HOH HOH A . 
E 5 HOH 165 765  132 HOH HOH A . 
E 5 HOH 166 766  259 HOH HOH A . 
E 5 HOH 167 767  41  HOH HOH A . 
E 5 HOH 168 768  484 HOH HOH A . 
E 5 HOH 169 769  94  HOH HOH A . 
E 5 HOH 170 770  161 HOH HOH A . 
E 5 HOH 171 771  63  HOH HOH A . 
E 5 HOH 172 772  197 HOH HOH A . 
E 5 HOH 173 773  307 HOH HOH A . 
E 5 HOH 174 774  230 HOH HOH A . 
E 5 HOH 175 775  148 HOH HOH A . 
E 5 HOH 176 776  51  HOH HOH A . 
E 5 HOH 177 777  65  HOH HOH A . 
E 5 HOH 178 778  351 HOH HOH A . 
E 5 HOH 179 779  437 HOH HOH A . 
E 5 HOH 180 780  291 HOH HOH A . 
E 5 HOH 181 781  400 HOH HOH A . 
E 5 HOH 182 782  262 HOH HOH A . 
E 5 HOH 183 783  93  HOH HOH A . 
E 5 HOH 184 784  210 HOH HOH A . 
E 5 HOH 185 785  540 HOH HOH A . 
E 5 HOH 186 786  27  HOH HOH A . 
E 5 HOH 187 787  97  HOH HOH A . 
E 5 HOH 188 788  178 HOH HOH A . 
E 5 HOH 189 789  513 HOH HOH A . 
E 5 HOH 190 790  189 HOH HOH A . 
E 5 HOH 191 791  120 HOH HOH A . 
E 5 HOH 192 792  156 HOH HOH A . 
E 5 HOH 193 793  141 HOH HOH A . 
E 5 HOH 194 794  534 HOH HOH A . 
E 5 HOH 195 795  107 HOH HOH A . 
E 5 HOH 196 796  124 HOH HOH A . 
E 5 HOH 197 797  221 HOH HOH A . 
E 5 HOH 198 798  292 HOH HOH A . 
E 5 HOH 199 799  526 HOH HOH A . 
E 5 HOH 200 800  11  HOH HOH A . 
E 5 HOH 201 801  334 HOH HOH A . 
E 5 HOH 202 802  227 HOH HOH A . 
E 5 HOH 203 803  130 HOH HOH A . 
E 5 HOH 204 804  66  HOH HOH A . 
E 5 HOH 205 805  22  HOH HOH A . 
E 5 HOH 206 806  266 HOH HOH A . 
E 5 HOH 207 807  426 HOH HOH A . 
E 5 HOH 208 808  340 HOH HOH A . 
E 5 HOH 209 809  74  HOH HOH A . 
E 5 HOH 210 810  409 HOH HOH A . 
E 5 HOH 211 811  13  HOH HOH A . 
E 5 HOH 212 812  68  HOH HOH A . 
E 5 HOH 213 813  105 HOH HOH A . 
E 5 HOH 214 814  302 HOH HOH A . 
E 5 HOH 215 815  139 HOH HOH A . 
E 5 HOH 216 816  537 HOH HOH A . 
E 5 HOH 217 817  95  HOH HOH A . 
E 5 HOH 218 818  145 HOH HOH A . 
E 5 HOH 219 819  125 HOH HOH A . 
E 5 HOH 220 820  128 HOH HOH A . 
E 5 HOH 221 821  33  HOH HOH A . 
E 5 HOH 222 822  218 HOH HOH A . 
E 5 HOH 223 823  421 HOH HOH A . 
E 5 HOH 224 824  153 HOH HOH A . 
E 5 HOH 225 825  184 HOH HOH A . 
E 5 HOH 226 826  82  HOH HOH A . 
E 5 HOH 227 827  373 HOH HOH A . 
E 5 HOH 228 828  330 HOH HOH A . 
E 5 HOH 229 829  144 HOH HOH A . 
E 5 HOH 230 830  297 HOH HOH A . 
E 5 HOH 231 831  454 HOH HOH A . 
E 5 HOH 232 832  7   HOH HOH A . 
E 5 HOH 233 833  389 HOH HOH A . 
E 5 HOH 234 834  62  HOH HOH A . 
E 5 HOH 235 835  503 HOH HOH A . 
E 5 HOH 236 836  134 HOH HOH A . 
E 5 HOH 237 837  53  HOH HOH A . 
E 5 HOH 238 838  520 HOH HOH A . 
E 5 HOH 239 839  151 HOH HOH A . 
E 5 HOH 240 840  118 HOH HOH A . 
E 5 HOH 241 841  216 HOH HOH A . 
E 5 HOH 242 842  294 HOH HOH A . 
E 5 HOH 243 843  429 HOH HOH A . 
E 5 HOH 244 844  5   HOH HOH A . 
E 5 HOH 245 845  342 HOH HOH A . 
E 5 HOH 246 846  183 HOH HOH A . 
E 5 HOH 247 847  167 HOH HOH A . 
E 5 HOH 248 848  440 HOH HOH A . 
E 5 HOH 249 849  10  HOH HOH A . 
E 5 HOH 250 850  207 HOH HOH A . 
E 5 HOH 251 851  86  HOH HOH A . 
E 5 HOH 252 852  158 HOH HOH A . 
E 5 HOH 253 853  16  HOH HOH A . 
E 5 HOH 254 854  410 HOH HOH A . 
E 5 HOH 255 855  12  HOH HOH A . 
E 5 HOH 256 856  316 HOH HOH A . 
E 5 HOH 257 857  171 HOH HOH A . 
E 5 HOH 258 858  44  HOH HOH A . 
E 5 HOH 259 859  163 HOH HOH A . 
E 5 HOH 260 860  121 HOH HOH A . 
E 5 HOH 261 861  511 HOH HOH A . 
E 5 HOH 262 862  166 HOH HOH A . 
E 5 HOH 263 863  143 HOH HOH A . 
E 5 HOH 264 864  311 HOH HOH A . 
E 5 HOH 265 865  203 HOH HOH A . 
E 5 HOH 266 866  472 HOH HOH A . 
E 5 HOH 267 867  81  HOH HOH A . 
E 5 HOH 268 868  54  HOH HOH A . 
E 5 HOH 269 869  388 HOH HOH A . 
E 5 HOH 270 870  113 HOH HOH A . 
E 5 HOH 271 871  329 HOH HOH A . 
E 5 HOH 272 872  352 HOH HOH A . 
E 5 HOH 273 873  362 HOH HOH A . 
E 5 HOH 274 874  246 HOH HOH A . 
E 5 HOH 275 875  37  HOH HOH A . 
E 5 HOH 276 876  147 HOH HOH A . 
E 5 HOH 277 877  35  HOH HOH A . 
E 5 HOH 278 878  213 HOH HOH A . 
E 5 HOH 279 879  2   HOH HOH A . 
E 5 HOH 280 880  85  HOH HOH A . 
E 5 HOH 281 881  18  HOH HOH A . 
E 5 HOH 282 882  112 HOH HOH A . 
E 5 HOH 283 883  177 HOH HOH A . 
E 5 HOH 284 884  76  HOH HOH A . 
E 5 HOH 285 885  17  HOH HOH A . 
E 5 HOH 286 886  39  HOH HOH A . 
E 5 HOH 287 887  507 HOH HOH A . 
E 5 HOH 288 888  279 HOH HOH A . 
E 5 HOH 289 889  99  HOH HOH A . 
E 5 HOH 290 890  50  HOH HOH A . 
E 5 HOH 291 891  385 HOH HOH A . 
E 5 HOH 292 892  556 HOH HOH A . 
E 5 HOH 293 893  257 HOH HOH A . 
E 5 HOH 294 894  450 HOH HOH A . 
E 5 HOH 295 895  58  HOH HOH A . 
E 5 HOH 296 896  402 HOH HOH A . 
E 5 HOH 297 897  344 HOH HOH A . 
E 5 HOH 298 898  298 HOH HOH A . 
E 5 HOH 299 899  358 HOH HOH A . 
E 5 HOH 300 900  293 HOH HOH A . 
E 5 HOH 301 901  570 HOH HOH A . 
E 5 HOH 302 902  236 HOH HOH A . 
E 5 HOH 303 903  173 HOH HOH A . 
E 5 HOH 304 904  533 HOH HOH A . 
E 5 HOH 305 905  48  HOH HOH A . 
E 5 HOH 306 906  506 HOH HOH A . 
E 5 HOH 307 907  232 HOH HOH A . 
E 5 HOH 308 908  192 HOH HOH A . 
E 5 HOH 309 909  541 HOH HOH A . 
E 5 HOH 310 910  324 HOH HOH A . 
E 5 HOH 311 911  249 HOH HOH A . 
E 5 HOH 312 912  195 HOH HOH A . 
E 5 HOH 313 913  28  HOH HOH A . 
E 5 HOH 314 914  196 HOH HOH A . 
E 5 HOH 315 915  413 HOH HOH A . 
E 5 HOH 316 916  182 HOH HOH A . 
E 5 HOH 317 917  301 HOH HOH A . 
E 5 HOH 318 918  575 HOH HOH A . 
E 5 HOH 319 919  176 HOH HOH A . 
E 5 HOH 320 920  40  HOH HOH A . 
E 5 HOH 321 921  483 HOH HOH A . 
E 5 HOH 322 922  59  HOH HOH A . 
E 5 HOH 323 923  527 HOH HOH A . 
E 5 HOH 324 924  138 HOH HOH A . 
E 5 HOH 325 925  471 HOH HOH A . 
E 5 HOH 326 926  47  HOH HOH A . 
E 5 HOH 327 927  191 HOH HOH A . 
E 5 HOH 328 928  238 HOH HOH A . 
E 5 HOH 329 929  61  HOH HOH A . 
E 5 HOH 330 930  494 HOH HOH A . 
E 5 HOH 331 931  60  HOH HOH A . 
E 5 HOH 332 932  31  HOH HOH A . 
E 5 HOH 333 933  204 HOH HOH A . 
E 5 HOH 334 934  499 HOH HOH A . 
E 5 HOH 335 935  223 HOH HOH A . 
E 5 HOH 336 936  299 HOH HOH A . 
E 5 HOH 337 937  135 HOH HOH A . 
E 5 HOH 338 938  9   HOH HOH A . 
E 5 HOH 339 939  546 HOH HOH A . 
E 5 HOH 340 940  129 HOH HOH A . 
E 5 HOH 341 941  476 HOH HOH A . 
E 5 HOH 342 942  67  HOH HOH A . 
E 5 HOH 343 943  321 HOH HOH A . 
E 5 HOH 344 944  209 HOH HOH A . 
E 5 HOH 345 945  75  HOH HOH A . 
E 5 HOH 346 946  251 HOH HOH A . 
E 5 HOH 347 947  390 HOH HOH A . 
E 5 HOH 348 948  280 HOH HOH A . 
E 5 HOH 349 949  250 HOH HOH A . 
E 5 HOH 350 950  498 HOH HOH A . 
E 5 HOH 351 951  87  HOH HOH A . 
E 5 HOH 352 952  260 HOH HOH A . 
E 5 HOH 353 953  263 HOH HOH A . 
E 5 HOH 354 954  545 HOH HOH A . 
E 5 HOH 355 955  108 HOH HOH A . 
E 5 HOH 356 956  341 HOH HOH A . 
E 5 HOH 357 957  296 HOH HOH A . 
E 5 HOH 358 958  91  HOH HOH A . 
E 5 HOH 359 959  478 HOH HOH A . 
E 5 HOH 360 960  560 HOH HOH A . 
E 5 HOH 361 961  457 HOH HOH A . 
E 5 HOH 362 962  206 HOH HOH A . 
E 5 HOH 363 963  274 HOH HOH A . 
E 5 HOH 364 964  350 HOH HOH A . 
E 5 HOH 365 965  553 HOH HOH A . 
E 5 HOH 366 966  371 HOH HOH A . 
E 5 HOH 367 967  346 HOH HOH A . 
E 5 HOH 368 968  322 HOH HOH A . 
E 5 HOH 369 969  381 HOH HOH A . 
E 5 HOH 370 970  404 HOH HOH A . 
E 5 HOH 371 971  431 HOH HOH A . 
E 5 HOH 372 972  451 HOH HOH A . 
E 5 HOH 373 973  222 HOH HOH A . 
E 5 HOH 374 974  461 HOH HOH A . 
E 5 HOH 375 975  268 HOH HOH A . 
E 5 HOH 376 976  401 HOH HOH A . 
E 5 HOH 377 977  337 HOH HOH A . 
E 5 HOH 378 978  349 HOH HOH A . 
E 5 HOH 379 979  366 HOH HOH A . 
E 5 HOH 380 980  502 HOH HOH A . 
E 5 HOH 381 981  305 HOH HOH A . 
E 5 HOH 382 982  403 HOH HOH A . 
E 5 HOH 383 983  355 HOH HOH A . 
E 5 HOH 384 984  475 HOH HOH A . 
E 5 HOH 385 985  525 HOH HOH A . 
E 5 HOH 386 986  245 HOH HOH A . 
E 5 HOH 387 987  57  HOH HOH A . 
E 5 HOH 388 988  548 HOH HOH A . 
E 5 HOH 389 989  164 HOH HOH A . 
E 5 HOH 390 990  175 HOH HOH A . 
E 5 HOH 391 991  554 HOH HOH A . 
E 5 HOH 392 992  446 HOH HOH A . 
E 5 HOH 393 993  515 HOH HOH A . 
E 5 HOH 394 994  281 HOH HOH A . 
E 5 HOH 395 995  106 HOH HOH A . 
E 5 HOH 396 996  356 HOH HOH A . 
E 5 HOH 397 997  237 HOH HOH A . 
E 5 HOH 398 998  563 HOH HOH A . 
E 5 HOH 399 999  423 HOH HOH A . 
E 5 HOH 400 1000 565 HOH HOH A . 
E 5 HOH 401 1001 418 HOH HOH A . 
E 5 HOH 402 1002 561 HOH HOH A . 
E 5 HOH 403 1003 425 HOH HOH A . 
E 5 HOH 404 1004 477 HOH HOH A . 
E 5 HOH 405 1005 495 HOH HOH A . 
E 5 HOH 406 1006 557 HOH HOH A . 
E 5 HOH 407 1007 391 HOH HOH A . 
E 5 HOH 408 1008 447 HOH HOH A . 
E 5 HOH 409 1009 283 HOH HOH A . 
E 5 HOH 410 1010 248 HOH HOH A . 
E 5 HOH 411 1011 288 HOH HOH A . 
E 5 HOH 412 1012 387 HOH HOH A . 
E 5 HOH 413 1013 374 HOH HOH A . 
E 5 HOH 414 1014 278 HOH HOH A . 
E 5 HOH 415 1015 333 HOH HOH A . 
E 5 HOH 416 1016 415 HOH HOH A . 
E 5 HOH 417 1017 126 HOH HOH A . 
E 5 HOH 418 1018 254 HOH HOH A . 
E 5 HOH 419 1019 559 HOH HOH A . 
E 5 HOH 420 1020 377 HOH HOH A . 
E 5 HOH 421 1021 411 HOH HOH A . 
E 5 HOH 422 1022 272 HOH HOH A . 
E 5 HOH 423 1023 455 HOH HOH A . 
E 5 HOH 424 1024 376 HOH HOH A . 
E 5 HOH 425 1025 159 HOH HOH A . 
E 5 HOH 426 1026 529 HOH HOH A . 
E 5 HOH 427 1027 504 HOH HOH A . 
E 5 HOH 428 1028 505 HOH HOH A . 
E 5 HOH 429 1029 508 HOH HOH A . 
E 5 HOH 430 1030 412 HOH HOH A . 
E 5 HOH 431 1031 468 HOH HOH A . 
E 5 HOH 432 1032 535 HOH HOH A . 
E 5 HOH 433 1033 224 HOH HOH A . 
E 5 HOH 434 1034 270 HOH HOH A . 
E 5 HOH 435 1035 142 HOH HOH A . 
E 5 HOH 436 1036 420 HOH HOH A . 
E 5 HOH 437 1037 552 HOH HOH A . 
E 5 HOH 438 1038 365 HOH HOH A . 
E 5 HOH 439 1039 271 HOH HOH A . 
E 5 HOH 440 1040 466 HOH HOH A . 
E 5 HOH 441 1041 77  HOH HOH A . 
E 5 HOH 442 1042 438 HOH HOH A . 
E 5 HOH 443 1043 277 HOH HOH A . 
E 5 HOH 444 1044 231 HOH HOH A . 
E 5 HOH 445 1045 460 HOH HOH A . 
E 5 HOH 446 1046 414 HOH HOH A . 
E 5 HOH 447 1047 576 HOH HOH A . 
E 5 HOH 448 1048 369 HOH HOH A . 
E 5 HOH 449 1049 436 HOH HOH A . 
E 5 HOH 450 1050 165 HOH HOH A . 
E 5 HOH 451 1051 544 HOH HOH A . 
E 5 HOH 452 1052 354 HOH HOH A . 
E 5 HOH 453 1053 312 HOH HOH A . 
E 5 HOH 454 1054 459 HOH HOH A . 
E 5 HOH 455 1055 170 HOH HOH A . 
E 5 HOH 456 1056 452 HOH HOH A . 
E 5 HOH 457 1057 481 HOH HOH A . 
E 5 HOH 458 1058 496 HOH HOH A . 
E 5 HOH 459 1059 441 HOH HOH A . 
E 5 HOH 460 1060 399 HOH HOH A . 
E 5 HOH 461 1061 378 HOH HOH A . 
E 5 HOH 462 1062 538 HOH HOH A . 
E 5 HOH 463 1063 4   HOH HOH A . 
E 5 HOH 464 1064 100 HOH HOH A . 
E 5 HOH 465 1065 185 HOH HOH A . 
E 5 HOH 466 1066 243 HOH HOH A . 
E 5 HOH 467 1067 309 HOH HOH A . 
E 5 HOH 468 1068 300 HOH HOH A . 
E 5 HOH 469 1069 287 HOH HOH A . 
E 5 HOH 470 1070 422 HOH HOH A . 
E 5 HOH 471 1071 375 HOH HOH A . 
E 5 HOH 472 1072 405 HOH HOH A . 
E 5 HOH 473 1073 261 HOH HOH A . 
E 5 HOH 474 1074 255 HOH HOH A . 
E 5 HOH 475 1075 331 HOH HOH A . 
E 5 HOH 476 1076 532 HOH HOH A . 
E 5 HOH 477 1077 443 HOH HOH A . 
E 5 HOH 478 1078 433 HOH HOH A . 
E 5 HOH 479 1079 519 HOH HOH A . 
E 5 HOH 480 1080 516 HOH HOH A . 
E 5 HOH 481 1081 490 HOH HOH A . 
E 5 HOH 482 1082 448 HOH HOH A . 
E 5 HOH 483 1083 382 HOH HOH A . 
E 5 HOH 484 1084 208 HOH HOH A . 
E 5 HOH 485 1085 458 HOH HOH A . 
E 5 HOH 486 1086 397 HOH HOH A . 
E 5 HOH 487 1087 430 HOH HOH A . 
E 5 HOH 488 1088 190 HOH HOH A . 
E 5 HOH 489 1089 434 HOH HOH A . 
E 5 HOH 490 1090 267 HOH HOH A . 
E 5 HOH 491 1091 487 HOH HOH A . 
E 5 HOH 492 1092 247 HOH HOH A . 
E 5 HOH 493 1093 275 HOH HOH A . 
E 5 HOH 494 1094 485 HOH HOH A . 
E 5 HOH 495 1095 510 HOH HOH A . 
E 5 HOH 496 1096 235 HOH HOH A . 
E 5 HOH 497 1097 380 HOH HOH A . 
E 5 HOH 498 1098 169 HOH HOH A . 
E 5 HOH 499 1099 332 HOH HOH A . 
E 5 HOH 500 1100 233 HOH HOH A . 
E 5 HOH 501 1101 444 HOH HOH A . 
E 5 HOH 502 1102 539 HOH HOH A . 
E 5 HOH 503 1103 133 HOH HOH A . 
E 5 HOH 504 1104 357 HOH HOH A . 
E 5 HOH 505 1105 543 HOH HOH A . 
E 5 HOH 506 1106 304 HOH HOH A . 
E 5 HOH 507 1107 456 HOH HOH A . 
E 5 HOH 508 1108 573 HOH HOH A . 
E 5 HOH 509 1109 336 HOH HOH A . 
E 5 HOH 510 1110 555 HOH HOH A . 
E 5 HOH 511 1111 469 HOH HOH A . 
E 5 HOH 512 1112 558 HOH HOH A . 
E 5 HOH 513 1113 359 HOH HOH A . 
E 5 HOH 514 1114 562 HOH HOH A . 
E 5 HOH 515 1115 564 HOH HOH A . 
E 5 HOH 516 1116 497 HOH HOH A . 
E 5 HOH 517 1117 407 HOH HOH A . 
E 5 HOH 518 1118 370 HOH HOH A . 
E 5 HOH 519 1119 442 HOH HOH A . 
E 5 HOH 520 1120 521 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YMY 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.427 
_cell.length_a_esd                 ? 
_cell.length_b                     67.405 
_cell.length_b_esd                 ? 
_cell.length_c                     86.435 
_cell.length_c_esd                 ? 
_cell.volume                       317099.930 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YMY 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YMY 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.07 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          40.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG 4000, sodium acetate, sodium chloride, cellotriose' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-03-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-5A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-5A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          9.85 
_reflns.entry_id                                       8YMY 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.01 
_reflns.d_resolution_low                               46.06 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     166668 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.072 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.01 
_reflns_shell.d_res_low                                     1.03 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.2 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             8180 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.970 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               10.90 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YMY 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.01 
_refine.ls_d_res_low                             46.06 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     166568 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  164563 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 1.20 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1624 
_refine.ls_R_factor_R_free                       0.1768 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1622 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.7244 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.0740 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.01 
_refine_hist.d_res_low                        46.06 
_refine_hist.number_atoms_solvent             520 
_refine_hist.number_atoms_total               3298 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2708 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         70 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0047 ? 3764 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9015 ? 5213 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0787 ? 587  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0069 ? 700  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.8214 ? 533  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.01 1.04  . . 141 11643 100.00 . . . . 0.2284 . . . . . . . . . . . 0.2592 
'X-RAY DIFFRACTION' 1.04 1.06  . . 142 11653 100.00 . . . . 0.2079 . . . . . . . . . . . 0.2210 
'X-RAY DIFFRACTION' 1.06 1.09  . . 141 11635 100.00 . . . . 0.1857 . . . . . . . . . . . 0.2083 
'X-RAY DIFFRACTION' 1.09 1.13  . . 142 11628 100.00 . . . . 0.1835 . . . . . . . . . . . 0.1852 
'X-RAY DIFFRACTION' 1.13 1.17  . . 142 11688 100.00 . . . . 0.1709 . . . . . . . . . . . 0.1848 
'X-RAY DIFFRACTION' 1.17 1.22  . . 142 11686 100.00 . . . . 0.1630 . . . . . . . . . . . 0.1867 
'X-RAY DIFFRACTION' 1.22 1.27  . . 142 11688 99.99  . . . . 0.1574 . . . . . . . . . . . 0.1533 
'X-RAY DIFFRACTION' 1.27 1.34  . . 142 11651 100.00 . . . . 0.1550 . . . . . . . . . . . 0.1832 
'X-RAY DIFFRACTION' 1.34 1.42  . . 143 11778 99.99  . . . . 0.1534 . . . . . . . . . . . 0.1720 
'X-RAY DIFFRACTION' 1.42 1.53  . . 142 11709 99.99  . . . . 0.1476 . . . . . . . . . . . 0.1758 
'X-RAY DIFFRACTION' 1.53 1.69  . . 143 11787 99.99  . . . . 0.1501 . . . . . . . . . . . 0.1683 
'X-RAY DIFFRACTION' 1.69 1.93  . . 144 11834 99.97  . . . . 0.1644 . . . . . . . . . . . 0.1782 
'X-RAY DIFFRACTION' 1.93 2.43  . . 145 11895 99.96  . . . . 0.1608 . . . . . . . . . . . 0.1863 
'X-RAY DIFFRACTION' 2.43 46.06 . . 149 12288 100.00 . . . . 0.1580 . . . . . . . . . . . 0.1621 
# 
_struct.entry_id                     8YMY 
_struct.title                        
;X-Ray crystal structure of glycoside hydrolase family 6 cellobiohydrolase from Phanerochaete chrysosporium PcCel6A C240S/R347K/C393S cocrystallized with cellotriose
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YMY 
_struct_keywords.text            'Glycoside hydrolase family 6, cellobiohydrolase, cellulase, catalytic domain, mutant, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    H3K419_PHACH 
_struct_ref.pdbx_db_accession          H3K419 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLACV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGECDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_struct_ref.pdbx_align_begin           82 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YMY 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 358 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             H3K419 
_struct_ref_seq.db_align_beg                  82 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  439 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       82 
_struct_ref_seq.pdbx_auth_seq_align_end       439 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YMY SER A 159 ? UNP H3K419 CYS 240 'engineered mutation' 240 1 
1 8YMY LYS A 266 ? UNP H3K419 ARG 347 'engineered mutation' 347 2 
1 8YMY SER A 312 ? UNP H3K419 CYS 393 'engineered mutation' 393 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                
;Software (PISA) determined protein interfaces have not revealed any specific interactions that could form stable quaternary structures.
;
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 14  ? GLN A 27  ? SER A 95  GLN A 108 1 ? 14 
HELX_P HELX_P2  AA2 ASP A 30  ? VAL A 40  ? ASP A 111 VAL A 121 1 ? 11 
HELX_P HELX_P3  AA3 ALA A 41  ? ILE A 43  ? ALA A 122 ILE A 124 5 ? 3  
HELX_P HELX_P4  AA4 SER A 51  ? ALA A 53  ? SER A 132 ALA A 134 5 ? 3  
HELX_P HELX_P5  AA5 LYS A 54  ? GLY A 73  ? LYS A 135 GLY A 154 1 ? 20 
HELX_P HELX_P6  AA6 ASN A 104 ? GLN A 121 ? ASN A 185 GLN A 202 1 ? 18 
HELX_P HELX_P7  AA7 ASP A 135 ? ASN A 143 ? ASP A 216 ASN A 224 1 ? 9  
HELX_P HELX_P8  AA8 VAL A 146 ? LYS A 169 ? VAL A 227 LYS A 250 1 ? 24 
HELX_P HELX_P9  AA9 TRP A 186 ? ALA A 204 ? TRP A 267 ALA A 285 1 ? 19 
HELX_P HELX_P10 AB1 ASP A 229 ? GLN A 233 ? ASP A 310 GLN A 314 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 239 ? ALA A 254 ? ASP A 320 ALA A 335 1 ? 16 
HELX_P HELX_P12 AB3 ASP A 324 ? LEU A 329 ? ASP A 405 LEU A 410 5 ? 6  
HELX_P HELX_P13 AB4 PHE A 343 ? ALA A 353 ? PHE A 424 ALA A 434 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 90  SG ? ? ? 1_555 A CYS 149 SG ? ? A CYS 171 A CYS 230 1_555 ? ? ? ? ? ? ? 2.051 ? ? 
disulf2 disulf ?    ? A CYS 280 SG A ? ? 1_555 A CYS 327 SG A ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.036 ? ? 
disulf3 disulf ?    ? A CYS 280 SG B ? ? 1_555 A CYS 327 SG B ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
covale1 covale both ? B GLC .   O4 A ? ? 1_555 B BGC .   C1 A ? B GLC 1   B BGC 2   1_555 ? ? ? ? ? ? ? 1.444 ? ? 
covale2 covale both ? B BGC .   O4 B ? ? 1_555 B BGC .   C1 B ? B BGC 1   B BGC 2   1_555 ? ? ? ? ? ? ? 1.429 ? ? 
covale3 covale both ? C BGC .   O4 ? ? ? 1_555 C BGC .   C1 ? ? C BGC 1   C BGC 2   1_555 ? ? ? ? ? ? ? 1.433 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 90  ? CYS A 149 ? CYS A 171 ? 1_555 CYS A 230 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 280 A CYS A 327 A CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 280 B CYS A 327 B CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLN 334 A . ? GLN 415 A PRO 335 A ? PRO 416 A 1 -2.47 
2 ASN 355 A . ? ASN 436 A PRO 356 A ? PRO 437 A 1 1.94  
3 ASN 355 A . ? ASN 436 A PRO 356 A ? PRO 437 A 1 6.83  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA2 5 6 ? parallel 
AA2 6 7 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA1 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA1 3 THR A 47  ? LEU A 49  ? THR A 128 LEU A 130 
AA2 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA2 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA2 3 ARG A 127 ? ILE A 132 ? ARG A 208 ILE A 213 
AA2 4 TYR A 173 ? ASP A 177 ? TYR A 254 ASP A 258 
AA2 5 ILE A 210 ? THR A 215 ? ILE A 291 THR A 296 
AA2 6 THR A 259 ? ASP A 263 ? THR A 340 ASP A 344 
AA2 7 ILE A 300 ? VAL A 304 ? ILE A 381 VAL A 385 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA1 2 3 O VAL A 81  ? O VAL A 162 N LEU A 49  ? N LEU A 130 
AA2 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA2 2 3 N VAL A 78  ? N VAL A 159 O ARG A 127 ? O ARG A 208 
AA2 3 4 N ALA A 130 ? N ALA A 211 O TYR A 173 ? O TYR A 254 
AA2 4 5 N MET A 176 ? N MET A 257 O GLY A 212 ? O GLY A 293 
AA2 5 6 N THR A 215 ? N THR A 296 O ASP A 263 ? O ASP A 344 
AA2 6 7 N VAL A 262 ? N VAL A 343 O VAL A 304 ? O VAL A 385 
# 
_pdbx_entry_details.entry_id                   8YMY 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ALA A 83  ? B -135.25 -32.40  
2  1 TYR A 164 ? ? -151.45 71.49   
3  1 ASP A 165 ? ? -150.09 32.07   
4  1 ASN A 184 ? A -96.37  59.64   
5  1 GLU A 214 ? ? 51.53   76.65   
6  1 ASP A 216 ? A 81.61   -24.44  
7  1 VAL A 222 ? B -93.15  -67.27  
8  1 ALA A 299 ? B 71.68   -7.48   
9  1 ASN A 300 ? A -116.69 -169.53 
10 1 ASN A 300 ? B -98.52  -155.57 
11 1 TYR A 301 ? B -145.99 17.58   
12 1 VAL A 387 ? ? -91.30  -61.94  
# 
loop_
_pdbx_molecule_features.prd_id 
_pdbx_molecule_features.name 
_pdbx_molecule_features.type 
_pdbx_molecule_features.class 
_pdbx_molecule_features.details 
PRD_900005 beta-cellobiose  Oligosaccharide Metabolism oligosaccharide 
PRD_900023 alpha-cellobiose Oligosaccharide Metabolism oligosaccharide 
# 
loop_
_pdbx_molecule.instance_id 
_pdbx_molecule.prd_id 
_pdbx_molecule.asym_id 
1 PRD_900023 B 
2 PRD_900005 C 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1120 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.89 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
BGC C2   C N R 74  
BGC C3   C N S 75  
BGC C4   C N S 76  
BGC C5   C N R 77  
BGC C6   C N N 78  
BGC C1   C N R 79  
BGC O1   O N N 80  
BGC O2   O N N 81  
BGC O3   O N N 82  
BGC O4   O N N 83  
BGC O5   O N N 84  
BGC O6   O N N 85  
BGC H2   H N N 86  
BGC H3   H N N 87  
BGC H4   H N N 88  
BGC H5   H N N 89  
BGC H61  H N N 90  
BGC H62  H N N 91  
BGC H1   H N N 92  
BGC HO1  H N N 93  
BGC HO2  H N N 94  
BGC HO3  H N N 95  
BGC HO4  H N N 96  
BGC HO6  H N N 97  
CYS N    N N N 98  
CYS CA   C N R 99  
CYS C    C N N 100 
CYS O    O N N 101 
CYS CB   C N N 102 
CYS SG   S N N 103 
CYS OXT  O N N 104 
CYS H    H N N 105 
CYS H2   H N N 106 
CYS HA   H N N 107 
CYS HB2  H N N 108 
CYS HB3  H N N 109 
CYS HG   H N N 110 
CYS HXT  H N N 111 
GLC C1   C N S 112 
GLC C2   C N R 113 
GLC C3   C N S 114 
GLC C4   C N S 115 
GLC C5   C N R 116 
GLC C6   C N N 117 
GLC O1   O N N 118 
GLC O2   O N N 119 
GLC O3   O N N 120 
GLC O4   O N N 121 
GLC O5   O N N 122 
GLC O6   O N N 123 
GLC H1   H N N 124 
GLC H2   H N N 125 
GLC H3   H N N 126 
GLC H4   H N N 127 
GLC H5   H N N 128 
GLC H61  H N N 129 
GLC H62  H N N 130 
GLC HO1  H N N 131 
GLC HO2  H N N 132 
GLC HO3  H N N 133 
GLC HO4  H N N 134 
GLC HO6  H N N 135 
GLN N    N N N 136 
GLN CA   C N S 137 
GLN C    C N N 138 
GLN O    O N N 139 
GLN CB   C N N 140 
GLN CG   C N N 141 
GLN CD   C N N 142 
GLN OE1  O N N 143 
GLN NE2  N N N 144 
GLN OXT  O N N 145 
GLN H    H N N 146 
GLN H2   H N N 147 
GLN HA   H N N 148 
GLN HB2  H N N 149 
GLN HB3  H N N 150 
GLN HG2  H N N 151 
GLN HG3  H N N 152 
GLN HE21 H N N 153 
GLN HE22 H N N 154 
GLN HXT  H N N 155 
GLU N    N N N 156 
GLU CA   C N S 157 
GLU C    C N N 158 
GLU O    O N N 159 
GLU CB   C N N 160 
GLU CG   C N N 161 
GLU CD   C N N 162 
GLU OE1  O N N 163 
GLU OE2  O N N 164 
GLU OXT  O N N 165 
GLU H    H N N 166 
GLU H2   H N N 167 
GLU HA   H N N 168 
GLU HB2  H N N 169 
GLU HB3  H N N 170 
GLU HG2  H N N 171 
GLU HG3  H N N 172 
GLU HE2  H N N 173 
GLU HXT  H N N 174 
GLY N    N N N 175 
GLY CA   C N N 176 
GLY C    C N N 177 
GLY O    O N N 178 
GLY OXT  O N N 179 
GLY H    H N N 180 
GLY H2   H N N 181 
GLY HA2  H N N 182 
GLY HA3  H N N 183 
GLY HXT  H N N 184 
HIS N    N N N 185 
HIS CA   C N S 186 
HIS C    C N N 187 
HIS O    O N N 188 
HIS CB   C N N 189 
HIS CG   C Y N 190 
HIS ND1  N Y N 191 
HIS CD2  C Y N 192 
HIS CE1  C Y N 193 
HIS NE2  N Y N 194 
HIS OXT  O N N 195 
HIS H    H N N 196 
HIS H2   H N N 197 
HIS HA   H N N 198 
HIS HB2  H N N 199 
HIS HB3  H N N 200 
HIS HD1  H N N 201 
HIS HD2  H N N 202 
HIS HE1  H N N 203 
HIS HE2  H N N 204 
HIS HXT  H N N 205 
HOH O    O N N 206 
HOH H1   H N N 207 
HOH H2   H N N 208 
ILE N    N N N 209 
ILE CA   C N S 210 
ILE C    C N N 211 
ILE O    O N N 212 
ILE CB   C N S 213 
ILE CG1  C N N 214 
ILE CG2  C N N 215 
ILE CD1  C N N 216 
ILE OXT  O N N 217 
ILE H    H N N 218 
ILE H2   H N N 219 
ILE HA   H N N 220 
ILE HB   H N N 221 
ILE HG12 H N N 222 
ILE HG13 H N N 223 
ILE HG21 H N N 224 
ILE HG22 H N N 225 
ILE HG23 H N N 226 
ILE HD11 H N N 227 
ILE HD12 H N N 228 
ILE HD13 H N N 229 
ILE HXT  H N N 230 
LEU N    N N N 231 
LEU CA   C N S 232 
LEU C    C N N 233 
LEU O    O N N 234 
LEU CB   C N N 235 
LEU CG   C N N 236 
LEU CD1  C N N 237 
LEU CD2  C N N 238 
LEU OXT  O N N 239 
LEU H    H N N 240 
LEU H2   H N N 241 
LEU HA   H N N 242 
LEU HB2  H N N 243 
LEU HB3  H N N 244 
LEU HG   H N N 245 
LEU HD11 H N N 246 
LEU HD12 H N N 247 
LEU HD13 H N N 248 
LEU HD21 H N N 249 
LEU HD22 H N N 250 
LEU HD23 H N N 251 
LEU HXT  H N N 252 
LYS N    N N N 253 
LYS CA   C N S 254 
LYS C    C N N 255 
LYS O    O N N 256 
LYS CB   C N N 257 
LYS CG   C N N 258 
LYS CD   C N N 259 
LYS CE   C N N 260 
LYS NZ   N N N 261 
LYS OXT  O N N 262 
LYS H    H N N 263 
LYS H2   H N N 264 
LYS HA   H N N 265 
LYS HB2  H N N 266 
LYS HB3  H N N 267 
LYS HG2  H N N 268 
LYS HG3  H N N 269 
LYS HD2  H N N 270 
LYS HD3  H N N 271 
LYS HE2  H N N 272 
LYS HE3  H N N 273 
LYS HZ1  H N N 274 
LYS HZ2  H N N 275 
LYS HZ3  H N N 276 
LYS HXT  H N N 277 
MET N    N N N 278 
MET CA   C N S 279 
MET C    C N N 280 
MET O    O N N 281 
MET CB   C N N 282 
MET CG   C N N 283 
MET SD   S N N 284 
MET CE   C N N 285 
MET OXT  O N N 286 
MET H    H N N 287 
MET H2   H N N 288 
MET HA   H N N 289 
MET HB2  H N N 290 
MET HB3  H N N 291 
MET HG2  H N N 292 
MET HG3  H N N 293 
MET HE1  H N N 294 
MET HE2  H N N 295 
MET HE3  H N N 296 
MET HXT  H N N 297 
PHE N    N N N 298 
PHE CA   C N S 299 
PHE C    C N N 300 
PHE O    O N N 301 
PHE CB   C N N 302 
PHE CG   C Y N 303 
PHE CD1  C Y N 304 
PHE CD2  C Y N 305 
PHE CE1  C Y N 306 
PHE CE2  C Y N 307 
PHE CZ   C Y N 308 
PHE OXT  O N N 309 
PHE H    H N N 310 
PHE H2   H N N 311 
PHE HA   H N N 312 
PHE HB2  H N N 313 
PHE HB3  H N N 314 
PHE HD1  H N N 315 
PHE HD2  H N N 316 
PHE HE1  H N N 317 
PHE HE2  H N N 318 
PHE HZ   H N N 319 
PHE HXT  H N N 320 
PRO N    N N N 321 
PRO CA   C N S 322 
PRO C    C N N 323 
PRO O    O N N 324 
PRO CB   C N N 325 
PRO CG   C N N 326 
PRO CD   C N N 327 
PRO OXT  O N N 328 
PRO H    H N N 329 
PRO HA   H N N 330 
PRO HB2  H N N 331 
PRO HB3  H N N 332 
PRO HG2  H N N 333 
PRO HG3  H N N 334 
PRO HD2  H N N 335 
PRO HD3  H N N 336 
PRO HXT  H N N 337 
SER N    N N N 338 
SER CA   C N S 339 
SER C    C N N 340 
SER O    O N N 341 
SER CB   C N N 342 
SER OG   O N N 343 
SER OXT  O N N 344 
SER H    H N N 345 
SER H2   H N N 346 
SER HA   H N N 347 
SER HB2  H N N 348 
SER HB3  H N N 349 
SER HG   H N N 350 
SER HXT  H N N 351 
THR N    N N N 352 
THR CA   C N S 353 
THR C    C N N 354 
THR O    O N N 355 
THR CB   C N R 356 
THR OG1  O N N 357 
THR CG2  C N N 358 
THR OXT  O N N 359 
THR H    H N N 360 
THR H2   H N N 361 
THR HA   H N N 362 
THR HB   H N N 363 
THR HG1  H N N 364 
THR HG21 H N N 365 
THR HG22 H N N 366 
THR HG23 H N N 367 
THR HXT  H N N 368 
TRP N    N N N 369 
TRP CA   C N S 370 
TRP C    C N N 371 
TRP O    O N N 372 
TRP CB   C N N 373 
TRP CG   C Y N 374 
TRP CD1  C Y N 375 
TRP CD2  C Y N 376 
TRP NE1  N Y N 377 
TRP CE2  C Y N 378 
TRP CE3  C Y N 379 
TRP CZ2  C Y N 380 
TRP CZ3  C Y N 381 
TRP CH2  C Y N 382 
TRP OXT  O N N 383 
TRP H    H N N 384 
TRP H2   H N N 385 
TRP HA   H N N 386 
TRP HB2  H N N 387 
TRP HB3  H N N 388 
TRP HD1  H N N 389 
TRP HE1  H N N 390 
TRP HE3  H N N 391 
TRP HZ2  H N N 392 
TRP HZ3  H N N 393 
TRP HH2  H N N 394 
TRP HXT  H N N 395 
TYR N    N N N 396 
TYR CA   C N S 397 
TYR C    C N N 398 
TYR O    O N N 399 
TYR CB   C N N 400 
TYR CG   C Y N 401 
TYR CD1  C Y N 402 
TYR CD2  C Y N 403 
TYR CE1  C Y N 404 
TYR CE2  C Y N 405 
TYR CZ   C Y N 406 
TYR OH   O N N 407 
TYR OXT  O N N 408 
TYR H    H N N 409 
TYR H2   H N N 410 
TYR HA   H N N 411 
TYR HB2  H N N 412 
TYR HB3  H N N 413 
TYR HD1  H N N 414 
TYR HD2  H N N 415 
TYR HE1  H N N 416 
TYR HE2  H N N 417 
TYR HH   H N N 418 
TYR HXT  H N N 419 
VAL N    N N N 420 
VAL CA   C N S 421 
VAL C    C N N 422 
VAL O    O N N 423 
VAL CB   C N N 424 
VAL CG1  C N N 425 
VAL CG2  C N N 426 
VAL OXT  O N N 427 
VAL H    H N N 428 
VAL H2   H N N 429 
VAL HA   H N N 430 
VAL HB   H N N 431 
VAL HG11 H N N 432 
VAL HG12 H N N 433 
VAL HG13 H N N 434 
VAL HG21 H N N 435 
VAL HG22 H N N 436 
VAL HG23 H N N 437 
VAL HXT  H N N 438 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BGC C2  C3   sing N N 70  
BGC C2  C1   sing N N 71  
BGC C2  O2   sing N N 72  
BGC C2  H2   sing N N 73  
BGC C3  C4   sing N N 74  
BGC C3  O3   sing N N 75  
BGC C3  H3   sing N N 76  
BGC C4  C5   sing N N 77  
BGC C4  O4   sing N N 78  
BGC C4  H4   sing N N 79  
BGC C5  C6   sing N N 80  
BGC C5  O5   sing N N 81  
BGC C5  H5   sing N N 82  
BGC C6  O6   sing N N 83  
BGC C6  H61  sing N N 84  
BGC C6  H62  sing N N 85  
BGC C1  O1   sing N N 86  
BGC C1  O5   sing N N 87  
BGC C1  H1   sing N N 88  
BGC O1  HO1  sing N N 89  
BGC O2  HO2  sing N N 90  
BGC O3  HO3  sing N N 91  
BGC O4  HO4  sing N N 92  
BGC O6  HO6  sing N N 93  
CYS N   CA   sing N N 94  
CYS N   H    sing N N 95  
CYS N   H2   sing N N 96  
CYS CA  C    sing N N 97  
CYS CA  CB   sing N N 98  
CYS CA  HA   sing N N 99  
CYS C   O    doub N N 100 
CYS C   OXT  sing N N 101 
CYS CB  SG   sing N N 102 
CYS CB  HB2  sing N N 103 
CYS CB  HB3  sing N N 104 
CYS SG  HG   sing N N 105 
CYS OXT HXT  sing N N 106 
GLC C1  C2   sing N N 107 
GLC C1  O1   sing N N 108 
GLC C1  O5   sing N N 109 
GLC C1  H1   sing N N 110 
GLC C2  C3   sing N N 111 
GLC C2  O2   sing N N 112 
GLC C2  H2   sing N N 113 
GLC C3  C4   sing N N 114 
GLC C3  O3   sing N N 115 
GLC C3  H3   sing N N 116 
GLC C4  C5   sing N N 117 
GLC C4  O4   sing N N 118 
GLC C4  H4   sing N N 119 
GLC C5  C6   sing N N 120 
GLC C5  O5   sing N N 121 
GLC C5  H5   sing N N 122 
GLC C6  O6   sing N N 123 
GLC C6  H61  sing N N 124 
GLC C6  H62  sing N N 125 
GLC O1  HO1  sing N N 126 
GLC O2  HO2  sing N N 127 
GLC O3  HO3  sing N N 128 
GLC O4  HO4  sing N N 129 
GLC O6  HO6  sing N N 130 
GLN N   CA   sing N N 131 
GLN N   H    sing N N 132 
GLN N   H2   sing N N 133 
GLN CA  C    sing N N 134 
GLN CA  CB   sing N N 135 
GLN CA  HA   sing N N 136 
GLN C   O    doub N N 137 
GLN C   OXT  sing N N 138 
GLN CB  CG   sing N N 139 
GLN CB  HB2  sing N N 140 
GLN CB  HB3  sing N N 141 
GLN CG  CD   sing N N 142 
GLN CG  HG2  sing N N 143 
GLN CG  HG3  sing N N 144 
GLN CD  OE1  doub N N 145 
GLN CD  NE2  sing N N 146 
GLN NE2 HE21 sing N N 147 
GLN NE2 HE22 sing N N 148 
GLN OXT HXT  sing N N 149 
GLU N   CA   sing N N 150 
GLU N   H    sing N N 151 
GLU N   H2   sing N N 152 
GLU CA  C    sing N N 153 
GLU CA  CB   sing N N 154 
GLU CA  HA   sing N N 155 
GLU C   O    doub N N 156 
GLU C   OXT  sing N N 157 
GLU CB  CG   sing N N 158 
GLU CB  HB2  sing N N 159 
GLU CB  HB3  sing N N 160 
GLU CG  CD   sing N N 161 
GLU CG  HG2  sing N N 162 
GLU CG  HG3  sing N N 163 
GLU CD  OE1  doub N N 164 
GLU CD  OE2  sing N N 165 
GLU OE2 HE2  sing N N 166 
GLU OXT HXT  sing N N 167 
GLY N   CA   sing N N 168 
GLY N   H    sing N N 169 
GLY N   H2   sing N N 170 
GLY CA  C    sing N N 171 
GLY CA  HA2  sing N N 172 
GLY CA  HA3  sing N N 173 
GLY C   O    doub N N 174 
GLY C   OXT  sing N N 175 
GLY OXT HXT  sing N N 176 
HIS N   CA   sing N N 177 
HIS N   H    sing N N 178 
HIS N   H2   sing N N 179 
HIS CA  C    sing N N 180 
HIS CA  CB   sing N N 181 
HIS CA  HA   sing N N 182 
HIS C   O    doub N N 183 
HIS C   OXT  sing N N 184 
HIS CB  CG   sing N N 185 
HIS CB  HB2  sing N N 186 
HIS CB  HB3  sing N N 187 
HIS CG  ND1  sing Y N 188 
HIS CG  CD2  doub Y N 189 
HIS ND1 CE1  doub Y N 190 
HIS ND1 HD1  sing N N 191 
HIS CD2 NE2  sing Y N 192 
HIS CD2 HD2  sing N N 193 
HIS CE1 NE2  sing Y N 194 
HIS CE1 HE1  sing N N 195 
HIS NE2 HE2  sing N N 196 
HIS OXT HXT  sing N N 197 
HOH O   H1   sing N N 198 
HOH O   H2   sing N N 199 
ILE N   CA   sing N N 200 
ILE N   H    sing N N 201 
ILE N   H2   sing N N 202 
ILE CA  C    sing N N 203 
ILE CA  CB   sing N N 204 
ILE CA  HA   sing N N 205 
ILE C   O    doub N N 206 
ILE C   OXT  sing N N 207 
ILE CB  CG1  sing N N 208 
ILE CB  CG2  sing N N 209 
ILE CB  HB   sing N N 210 
ILE CG1 CD1  sing N N 211 
ILE CG1 HG12 sing N N 212 
ILE CG1 HG13 sing N N 213 
ILE CG2 HG21 sing N N 214 
ILE CG2 HG22 sing N N 215 
ILE CG2 HG23 sing N N 216 
ILE CD1 HD11 sing N N 217 
ILE CD1 HD12 sing N N 218 
ILE CD1 HD13 sing N N 219 
ILE OXT HXT  sing N N 220 
LEU N   CA   sing N N 221 
LEU N   H    sing N N 222 
LEU N   H2   sing N N 223 
LEU CA  C    sing N N 224 
LEU CA  CB   sing N N 225 
LEU CA  HA   sing N N 226 
LEU C   O    doub N N 227 
LEU C   OXT  sing N N 228 
LEU CB  CG   sing N N 229 
LEU CB  HB2  sing N N 230 
LEU CB  HB3  sing N N 231 
LEU CG  CD1  sing N N 232 
LEU CG  CD2  sing N N 233 
LEU CG  HG   sing N N 234 
LEU CD1 HD11 sing N N 235 
LEU CD1 HD12 sing N N 236 
LEU CD1 HD13 sing N N 237 
LEU CD2 HD21 sing N N 238 
LEU CD2 HD22 sing N N 239 
LEU CD2 HD23 sing N N 240 
LEU OXT HXT  sing N N 241 
LYS N   CA   sing N N 242 
LYS N   H    sing N N 243 
LYS N   H2   sing N N 244 
LYS CA  C    sing N N 245 
LYS CA  CB   sing N N 246 
LYS CA  HA   sing N N 247 
LYS C   O    doub N N 248 
LYS C   OXT  sing N N 249 
LYS CB  CG   sing N N 250 
LYS CB  HB2  sing N N 251 
LYS CB  HB3  sing N N 252 
LYS CG  CD   sing N N 253 
LYS CG  HG2  sing N N 254 
LYS CG  HG3  sing N N 255 
LYS CD  CE   sing N N 256 
LYS CD  HD2  sing N N 257 
LYS CD  HD3  sing N N 258 
LYS CE  NZ   sing N N 259 
LYS CE  HE2  sing N N 260 
LYS CE  HE3  sing N N 261 
LYS NZ  HZ1  sing N N 262 
LYS NZ  HZ2  sing N N 263 
LYS NZ  HZ3  sing N N 264 
LYS OXT HXT  sing N N 265 
MET N   CA   sing N N 266 
MET N   H    sing N N 267 
MET N   H2   sing N N 268 
MET CA  C    sing N N 269 
MET CA  CB   sing N N 270 
MET CA  HA   sing N N 271 
MET C   O    doub N N 272 
MET C   OXT  sing N N 273 
MET CB  CG   sing N N 274 
MET CB  HB2  sing N N 275 
MET CB  HB3  sing N N 276 
MET CG  SD   sing N N 277 
MET CG  HG2  sing N N 278 
MET CG  HG3  sing N N 279 
MET SD  CE   sing N N 280 
MET CE  HE1  sing N N 281 
MET CE  HE2  sing N N 282 
MET CE  HE3  sing N N 283 
MET OXT HXT  sing N N 284 
PHE N   CA   sing N N 285 
PHE N   H    sing N N 286 
PHE N   H2   sing N N 287 
PHE CA  C    sing N N 288 
PHE CA  CB   sing N N 289 
PHE CA  HA   sing N N 290 
PHE C   O    doub N N 291 
PHE C   OXT  sing N N 292 
PHE CB  CG   sing N N 293 
PHE CB  HB2  sing N N 294 
PHE CB  HB3  sing N N 295 
PHE CG  CD1  doub Y N 296 
PHE CG  CD2  sing Y N 297 
PHE CD1 CE1  sing Y N 298 
PHE CD1 HD1  sing N N 299 
PHE CD2 CE2  doub Y N 300 
PHE CD2 HD2  sing N N 301 
PHE CE1 CZ   doub Y N 302 
PHE CE1 HE1  sing N N 303 
PHE CE2 CZ   sing Y N 304 
PHE CE2 HE2  sing N N 305 
PHE CZ  HZ   sing N N 306 
PHE OXT HXT  sing N N 307 
PRO N   CA   sing N N 308 
PRO N   CD   sing N N 309 
PRO N   H    sing N N 310 
PRO CA  C    sing N N 311 
PRO CA  CB   sing N N 312 
PRO CA  HA   sing N N 313 
PRO C   O    doub N N 314 
PRO C   OXT  sing N N 315 
PRO CB  CG   sing N N 316 
PRO CB  HB2  sing N N 317 
PRO CB  HB3  sing N N 318 
PRO CG  CD   sing N N 319 
PRO CG  HG2  sing N N 320 
PRO CG  HG3  sing N N 321 
PRO CD  HD2  sing N N 322 
PRO CD  HD3  sing N N 323 
PRO OXT HXT  sing N N 324 
SER N   CA   sing N N 325 
SER N   H    sing N N 326 
SER N   H2   sing N N 327 
SER CA  C    sing N N 328 
SER CA  CB   sing N N 329 
SER CA  HA   sing N N 330 
SER C   O    doub N N 331 
SER C   OXT  sing N N 332 
SER CB  OG   sing N N 333 
SER CB  HB2  sing N N 334 
SER CB  HB3  sing N N 335 
SER OG  HG   sing N N 336 
SER OXT HXT  sing N N 337 
THR N   CA   sing N N 338 
THR N   H    sing N N 339 
THR N   H2   sing N N 340 
THR CA  C    sing N N 341 
THR CA  CB   sing N N 342 
THR CA  HA   sing N N 343 
THR C   O    doub N N 344 
THR C   OXT  sing N N 345 
THR CB  OG1  sing N N 346 
THR CB  CG2  sing N N 347 
THR CB  HB   sing N N 348 
THR OG1 HG1  sing N N 349 
THR CG2 HG21 sing N N 350 
THR CG2 HG22 sing N N 351 
THR CG2 HG23 sing N N 352 
THR OXT HXT  sing N N 353 
TRP N   CA   sing N N 354 
TRP N   H    sing N N 355 
TRP N   H2   sing N N 356 
TRP CA  C    sing N N 357 
TRP CA  CB   sing N N 358 
TRP CA  HA   sing N N 359 
TRP C   O    doub N N 360 
TRP C   OXT  sing N N 361 
TRP CB  CG   sing N N 362 
TRP CB  HB2  sing N N 363 
TRP CB  HB3  sing N N 364 
TRP CG  CD1  doub Y N 365 
TRP CG  CD2  sing Y N 366 
TRP CD1 NE1  sing Y N 367 
TRP CD1 HD1  sing N N 368 
TRP CD2 CE2  doub Y N 369 
TRP CD2 CE3  sing Y N 370 
TRP NE1 CE2  sing Y N 371 
TRP NE1 HE1  sing N N 372 
TRP CE2 CZ2  sing Y N 373 
TRP CE3 CZ3  doub Y N 374 
TRP CE3 HE3  sing N N 375 
TRP CZ2 CH2  doub Y N 376 
TRP CZ2 HZ2  sing N N 377 
TRP CZ3 CH2  sing Y N 378 
TRP CZ3 HZ3  sing N N 379 
TRP CH2 HH2  sing N N 380 
TRP OXT HXT  sing N N 381 
TYR N   CA   sing N N 382 
TYR N   H    sing N N 383 
TYR N   H2   sing N N 384 
TYR CA  C    sing N N 385 
TYR CA  CB   sing N N 386 
TYR CA  HA   sing N N 387 
TYR C   O    doub N N 388 
TYR C   OXT  sing N N 389 
TYR CB  CG   sing N N 390 
TYR CB  HB2  sing N N 391 
TYR CB  HB3  sing N N 392 
TYR CG  CD1  doub Y N 393 
TYR CG  CD2  sing Y N 394 
TYR CD1 CE1  sing Y N 395 
TYR CD1 HD1  sing N N 396 
TYR CD2 CE2  doub Y N 397 
TYR CD2 HD2  sing N N 398 
TYR CE1 CZ   doub Y N 399 
TYR CE1 HE1  sing N N 400 
TYR CE2 CZ   sing Y N 401 
TYR CE2 HE2  sing N N 402 
TYR CZ  OH   sing N N 403 
TYR OH  HH   sing N N 404 
TYR OXT HXT  sing N N 405 
VAL N   CA   sing N N 406 
VAL N   H    sing N N 407 
VAL N   H2   sing N N 408 
VAL CA  C    sing N N 409 
VAL CA  CB   sing N N 410 
VAL CA  HA   sing N N 411 
VAL C   O    doub N N 412 
VAL C   OXT  sing N N 413 
VAL CB  CG1  sing N N 414 
VAL CB  CG2  sing N N 415 
VAL CB  HB   sing N N 416 
VAL CG1 HG11 sing N N 417 
VAL CG1 HG12 sing N N 418 
VAL CG1 HG13 sing N N 419 
VAL CG2 HG21 sing N N 420 
VAL CG2 HG22 sing N N 421 
VAL CG2 HG23 sing N N 422 
VAL OXT HXT  sing N N 423 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           22J12651 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 GLC 1 y 
2 BGC 1 y 
2 BGC 2 n 
3 BGC 1 n 
3 BGC 2 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5XCY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YMY 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018373 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014836 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011569 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   A SER A 1 1   ? 26.83502  -26.11117 -23.38399 0.688 18.01980 ? 82   SER A N   1 
ATOM   2    N N   B SER A 1 1   ? 29.46292  -27.38286 -24.26947 0.312 15.52760 ? 82   SER A N   1 
ATOM   3    C CA  A SER A 1 1   ? 27.70507  -27.27379 -23.23485 0.688 12.72300 ? 82   SER A CA  1 
ATOM   4    C CA  B SER A 1 1   ? 28.65128  -27.47378 -23.06382 0.312 19.06823 ? 82   SER A CA  1 
ATOM   5    C C   A SER A 1 1   ? 26.94475  -28.43030 -22.59856 0.688 16.86772 ? 82   SER A C   1 
ATOM   6    C C   B SER A 1 1   ? 28.21698  -28.91314 -22.82116 0.312 14.26667 ? 82   SER A C   1 
ATOM   7    O O   A SER A 1 1   ? 25.73603  -28.56441 -22.78852 0.688 15.48428 ? 82   SER A O   1 
ATOM   8    O O   B SER A 1 1   ? 28.22152  -29.73262 -23.73875 0.312 17.78047 ? 82   SER A O   1 
ATOM   9    C CB  A SER A 1 1   ? 28.93405  -26.92462 -22.39352 0.688 17.88334 ? 82   SER A CB  1 
ATOM   10   C CB  B SER A 1 1   ? 27.41316  -26.58278 -23.18688 0.312 20.00135 ? 82   SER A CB  1 
ATOM   11   O OG  A SER A 1 1   ? 28.58142  -26.08991 -21.30659 0.688 18.22437 ? 82   SER A OG  1 
ATOM   12   O OG  B SER A 1 1   ? 27.74778  -25.28622 -23.64992 0.312 18.41619 ? 82   SER A OG  1 
ATOM   13   N N   A ALA A 1 2   ? 27.66049  -29.24299 -21.81744 0.688 17.94156 ? 83   ALA A N   1 
ATOM   14   N N   B ALA A 1 2   ? 27.84583  -29.21886 -21.57950 0.312 17.69345 ? 83   ALA A N   1 
ATOM   15   C CA  A ALA A 1 2   ? 27.09740  -30.49544 -21.31873 0.688 14.75536 ? 83   ALA A CA  1 
ATOM   16   C CA  B ALA A 1 2   ? 27.26120  -30.51571 -21.26321 0.312 14.81280 ? 83   ALA A CA  1 
ATOM   17   C C   A ALA A 1 2   ? 25.83816  -30.26681 -20.48979 0.688 8.67243  ? 83   ALA A C   1 
ATOM   18   C C   B ALA A 1 2   ? 26.04852  -30.35692 -20.36091 0.312 9.53345  ? 83   ALA A C   1 
ATOM   19   O O   A ALA A 1 2   ? 24.80721  -30.90351 -20.72810 0.688 13.15194 ? 83   ALA A O   1 
ATOM   20   O O   B ALA A 1 2   ? 25.10557  -31.14838 -20.43632 0.312 7.66937  ? 83   ALA A O   1 
ATOM   21   C CB  A ALA A 1 2   ? 28.14170  -31.25716 -20.50526 0.688 14.35146 ? 83   ALA A CB  1 
ATOM   22   C CB  B ALA A 1 2   ? 28.27949  -31.43773 -20.59843 0.312 15.33989 ? 83   ALA A CB  1 
ATOM   23   N N   A ASN A 1 3   ? 25.89802  -29.36142 -19.51845 0.688 10.33883 ? 84   ASN A N   1 
ATOM   24   N N   B ASN A 1 3   ? 26.06603  -29.35027 -19.50148 0.312 10.66032 ? 84   ASN A N   1 
ATOM   25   C CA  A ASN A 1 3   ? 24.86655  -29.23685 -18.48522 0.688 9.27166  ? 84   ASN A CA  1 
ATOM   26   C CA  B ASN A 1 3   ? 24.98480  -29.10596 -18.55788 0.312 10.14753 ? 84   ASN A CA  1 
ATOM   27   C C   A ASN A 1 3   ? 24.04903  -27.95992 -18.67892 0.688 8.98217  ? 84   ASN A C   1 
ATOM   28   C C   B ASN A 1 3   ? 24.23154  -27.86512 -19.01340 0.312 11.62346 ? 84   ASN A C   1 
ATOM   29   O O   A ASN A 1 3   ? 24.33609  -26.91856 -18.08033 0.688 11.82712 ? 84   ASN A O   1 
ATOM   30   O O   B ASN A 1 3   ? 24.75907  -26.75314 -18.93692 0.312 8.88558  ? 84   ASN A O   1 
ATOM   31   C CB  A ASN A 1 3   ? 25.51019  -29.26251 -17.11275 0.688 10.82984 ? 84   ASN A CB  1 
ATOM   32   C CB  B ASN A 1 3   ? 25.54451  -28.91067 -17.15086 0.312 11.51617 ? 84   ASN A CB  1 
ATOM   33   C CG  A ASN A 1 3   ? 24.49758  -29.29636 -16.00383 0.688 9.34676  ? 84   ASN A CG  1 
ATOM   34   C CG  B ASN A 1 3   ? 24.45760  -28.76713 -16.10540 0.312 13.31641 ? 84   ASN A CG  1 
ATOM   35   O OD1 A ASN A 1 3   ? 23.37767  -29.75966 -16.19351 0.688 10.87830 ? 84   ASN A OD1 1 
ATOM   36   O OD1 B ASN A 1 3   ? 23.27600  -28.98474 -16.38032 0.312 14.13268 ? 84   ASN A OD1 1 
ATOM   37   N ND2 A ASN A 1 3   ? 24.88276  -28.81041 -14.83444 0.688 9.98433  ? 84   ASN A ND2 1 
ATOM   38   N ND2 B ASN A 1 3   ? 24.85391  -28.39965 -14.89505 0.312 12.44938 ? 84   ASN A ND2 1 
ATOM   39   N N   . ASN A 1 4   ? 23.00724  -28.05664 -19.50089 1.000 9.40179  ? 85   ASN A N   1 
ATOM   40   C CA  . ASN A 1 4   ? 22.07485  -26.95433 -19.69520 1.000 8.27421  ? 85   ASN A CA  1 
ATOM   41   C C   . ASN A 1 4   ? 21.02941  -27.05509 -18.59472 1.000 7.98646  ? 85   ASN A C   1 
ATOM   42   O O   . ASN A 1 4   ? 20.36027  -28.09526 -18.50238 1.000 7.92471  ? 85   ASN A O   1 
ATOM   43   C CB  . ASN A 1 4   ? 21.41387  -27.06639 -21.06055 1.000 8.76342  ? 85   ASN A CB  1 
ATOM   44   C CG  . ASN A 1 4   ? 20.47248  -25.91434 -21.35571 1.000 8.08067  ? 85   ASN A CG  1 
ATOM   45   O OD1 . ASN A 1 4   ? 19.74287  -25.43879 -20.48333 1.000 8.92082  ? 85   ASN A OD1 1 
ATOM   46   N ND2 . ASN A 1 4   ? 20.45455  -25.48219 -22.60420 1.000 8.77145  ? 85   ASN A ND2 1 
ATOM   47   N N   . PRO A 1 5   ? 20.86470  -26.04013 -17.73772 1.000 7.71300  ? 86   PRO A N   1 
ATOM   48   C CA  . PRO A 1 5   ? 19.96233  -26.19528 -16.58500 1.000 7.82176  ? 86   PRO A CA  1 
ATOM   49   C C   . PRO A 1 5   ? 18.53683  -26.57966 -16.94928 1.000 7.80782  ? 86   PRO A C   1 
ATOM   50   O O   . PRO A 1 5   ? 17.83249  -27.15460 -16.10888 1.000 8.70754  ? 86   PRO A O   1 
ATOM   51   C CB  . PRO A 1 5   ? 20.00687  -24.81604 -15.91659 1.000 9.91113  ? 86   PRO A CB  1 
ATOM   52   C CG  . PRO A 1 5   ? 21.35124  -24.28119 -16.29022 1.000 9.38674  ? 86   PRO A CG  1 
ATOM   53   C CD  . PRO A 1 5   ? 21.56197  -24.74387 -17.70943 1.000 9.21795  ? 86   PRO A CD  1 
ATOM   54   N N   A TRP A 1 6   ? 18.08229  -26.27059 -18.16438 0.815 7.90440  ? 87   TRP A N   1 
ATOM   55   N N   B TRP A 1 6   ? 18.09011  -26.29363 -18.17201 0.185 7.99049  ? 87   TRP A N   1 
ATOM   56   C CA  A TRP A 1 6   ? 16.71086  -26.57448 -18.55505 0.815 7.42222  ? 87   TRP A CA  1 
ATOM   57   C CA  B TRP A 1 6   ? 16.69050  -26.47546 -18.53931 0.185 7.46042  ? 87   TRP A CA  1 
ATOM   58   C C   A TRP A 1 6   ? 16.50048  -28.01309 -19.01646 0.815 7.64855  ? 87   TRP A C   1 
ATOM   59   C C   B TRP A 1 6   ? 16.35940  -27.89810 -18.97982 0.185 8.20490  ? 87   TRP A C   1 
ATOM   60   O O   A TRP A 1 6   ? 15.35149  -28.47212 -19.02640 0.815 8.67974  ? 87   TRP A O   1 
ATOM   61   O O   B TRP A 1 6   ? 15.27842  -28.39976 -18.65405 0.185 6.80609  ? 87   TRP A O   1 
ATOM   62   C CB  A TRP A 1 6   ? 16.23291  -25.59019 -19.62566 0.815 7.87114  ? 87   TRP A CB  1 
ATOM   63   C CB  B TRP A 1 6   ? 16.30767  -25.48758 -19.64293 0.185 8.21594  ? 87   TRP A CB  1 
ATOM   64   C CG  A TRP A 1 6   ? 15.84864  -24.29236 -19.01569 0.815 7.37938  ? 87   TRP A CG  1 
ATOM   65   C CG  B TRP A 1 6   ? 15.76422  -24.20654 -19.10936 0.185 7.32564  ? 87   TRP A CG  1 
ATOM   66   C CD1 A TRP A 1 6   ? 14.62437  -23.97167 -18.52258 0.815 7.67220  ? 87   TRP A CD1 1 
ATOM   67   C CD1 B TRP A 1 6   ? 14.47300  -23.94760 -18.76161 0.185 7.60367  ? 87   TRP A CD1 1 
ATOM   68   C CD2 A TRP A 1 6   ? 16.69378  -23.16194 -18.76960 0.815 6.99493  ? 87   TRP A CD2 1 
ATOM   69   C CD2 B TRP A 1 6   ? 16.50183  -23.00863 -18.84326 0.185 6.60628  ? 87   TRP A CD2 1 
ATOM   70   N NE1 A TRP A 1 6   ? 14.64341  -22.70866 -17.99428 0.815 7.14426  ? 87   TRP A NE1 1 
ATOM   71   N NE1 B TRP A 1 6   ? 14.35713  -22.65839 -18.30091 0.185 7.48333  ? 87   TRP A NE1 1 
ATOM   72   C CE2 A TRP A 1 6   ? 15.90179  -22.18732 -18.13535 0.815 6.88445  ? 87   TRP A CE2 1 
ATOM   73   C CE2 B TRP A 1 6   ? 15.59033  -22.06107 -18.33904 0.185 8.19719  ? 87   TRP A CE2 1 
ATOM   74   C CE3 A TRP A 1 6   ? 18.04069  -22.88009 -19.02314 0.815 7.06213  ? 87   TRP A CE3 1 
ATOM   75   C CE3 B TRP A 1 6   ? 17.84441  -22.64540 -18.98481 0.185 8.23337  ? 87   TRP A CE3 1 
ATOM   76   C CZ2 A TRP A 1 6   ? 16.40268  -20.94593 -17.75309 0.815 7.87610  ? 87   TRP A CZ2 1 
ATOM   77   C CZ2 B TRP A 1 6   ? 15.97810  -20.77110 -17.97586 0.185 7.12599  ? 87   TRP A CZ2 1 
ATOM   78   C CZ3 A TRP A 1 6   ? 18.53716  -21.64421 -18.64454 0.815 7.19560  ? 87   TRP A CZ3 1 
ATOM   79   C CZ3 B TRP A 1 6   ? 18.22751  -21.36639 -18.62399 0.185 6.80858  ? 87   TRP A CZ3 1 
ATOM   80   C CH2 A TRP A 1 6   ? 17.72080  -20.69207 -18.01655 0.815 7.83738  ? 87   TRP A CH2 1 
ATOM   81   C CH2 B TRP A 1 6   ? 17.29803  -20.44409 -18.12556 0.185 6.82362  ? 87   TRP A CH2 1 
ATOM   82   N N   A THR A 1 7   ? 17.55305  -28.73149 -19.40772 0.815 7.45162  ? 88   THR A N   1 
ATOM   83   N N   B THR A 1 7   ? 17.26302  -28.55536 -19.70925 0.185 8.23792  ? 88   THR A N   1 
ATOM   84   C CA  A THR A 1 7   ? 17.35146  -30.07964 -19.92618 0.815 7.89847  ? 88   THR A CA  1 
ATOM   85   C CA  B THR A 1 7   ? 16.96949  -29.84854 -20.32261 0.185 7.65558  ? 88   THR A CA  1 
ATOM   86   C C   A THR A 1 7   ? 16.73557  -30.96079 -18.85414 0.815 7.77208  ? 88   THR A C   1 
ATOM   87   C C   B THR A 1 7   ? 16.42863  -30.85252 -19.30859 0.185 7.58510  ? 88   THR A C   1 
ATOM   88   O O   A THR A 1 7   ? 17.21880  -31.01171 -17.72090 0.815 9.31595  ? 88   THR A O   1 
ATOM   89   O O   B THR A 1 7   ? 16.97897  -31.01498 -18.21598 0.185 7.20278  ? 88   THR A O   1 
ATOM   90   C CB  A THR A 1 7   ? 18.67751  -30.68666 -20.36455 0.815 8.55681  ? 88   THR A CB  1 
ATOM   91   C CB  B THR A 1 7   ? 18.23631  -30.39839 -20.98364 0.185 8.44693  ? 88   THR A CB  1 
ATOM   92   O OG1 A THR A 1 7   ? 19.27284  -29.84534 -21.34591 0.815 9.67737  ? 88   THR A OG1 1 
ATOM   93   O OG1 B THR A 1 7   ? 18.77703  -29.41064 -21.86833 0.185 6.11200  ? 88   THR A OG1 1 
ATOM   94   C CG2 A THR A 1 7   ? 18.46499  -32.07551 -20.96765 0.815 10.25682 ? 88   THR A CG2 1 
ATOM   95   C CG2 B THR A 1 7   ? 17.92399  -31.66246 -21.76807 0.185 10.08822 ? 88   THR A CG2 1 
ATOM   96   N N   A GLY A 1 8   ? 15.66865  -31.66333 -19.21943 0.815 8.62492  ? 89   GLY A N   1 
ATOM   97   N N   B GLY A 1 8   ? 15.33723  -31.51666 -19.68017 0.185 5.97341  ? 89   GLY A N   1 
ATOM   98   C CA  A GLY A 1 8   ? 15.08810  -32.66179 -18.35401 0.815 8.01919  ? 89   GLY A CA  1 
ATOM   99   C CA  B GLY A 1 8   ? 14.68215  -32.53073 -18.86066 0.185 9.11444  ? 89   GLY A CA  1 
ATOM   100  C C   A GLY A 1 8   ? 14.13158  -32.13461 -17.31629 0.815 7.64062  ? 89   GLY A C   1 
ATOM   101  C C   B GLY A 1 8   ? 13.60100  -32.02403 -17.91753 0.185 10.74099 ? 89   GLY A C   1 
ATOM   102  O O   A GLY A 1 8   ? 13.66833  -32.92257 -16.47899 0.815 9.03468  ? 89   GLY A O   1 
ATOM   103  O O   B GLY A 1 8   ? 12.58847  -32.69532 -17.70581 0.185 15.51440 ? 89   GLY A O   1 
ATOM   104  N N   . PHE A 1 9   ? 13.80657  -30.84018 -17.34984 1.000 8.05901  ? 90   PHE A N   1 
ATOM   105  C CA  . PHE A 1 9   ? 12.88721  -30.24147 -16.39367 1.000 8.19175  ? 90   PHE A CA  1 
ATOM   106  C C   . PHE A 1 9   ? 11.68848  -29.62956 -17.10316 1.000 9.00024  ? 90   PHE A C   1 
ATOM   107  O O   . PHE A 1 9   ? 11.77183  -29.22080 -18.26290 1.000 9.32251  ? 90   PHE A O   1 
ATOM   108  C CB  . PHE A 1 9   ? 13.60132  -29.14424 -15.59050 1.000 9.95556  ? 90   PHE A CB  1 
ATOM   109  C CG  . PHE A 1 9   ? 14.55583  -29.68637 -14.57411 1.000 8.77894  ? 90   PHE A CG  1 
ATOM   110  C CD1 . PHE A 1 9   ? 15.82095  -30.12100 -14.94544 1.000 9.80900  ? 90   PHE A CD1 1 
ATOM   111  C CD2 . PHE A 1 9   ? 14.18175  -29.79611 -13.24505 1.000 9.50461  ? 90   PHE A CD2 1 
ATOM   112  C CE1 . PHE A 1 9   ? 16.68051  -30.66105 -14.00848 1.000 11.56661 ? 90   PHE A CE1 1 
ATOM   113  C CE2 . PHE A 1 9   ? 15.04722  -30.32378 -12.30823 1.000 11.70720 ? 90   PHE A CE2 1 
ATOM   114  C CZ  . PHE A 1 9   ? 16.29410  -30.75652 -12.68806 1.000 10.96495 ? 90   PHE A CZ  1 
ATOM   115  N N   . GLN A 1 10  ? 10.56252  -29.58629 -16.39879 1.000 8.84662  ? 91   GLN A N   1 
ATOM   116  C CA  A GLN A 1 10  ? 9.40479   -28.80011 -16.80396 0.504 8.92046  ? 91   GLN A CA  1 
ATOM   117  C CA  B GLN A 1 10  ? 9.42026   -28.79453 -16.81932 0.496 8.96252  ? 91   GLN A CA  1 
ATOM   118  C C   . GLN A 1 10  ? 9.47321   -27.47281 -16.06494 1.000 7.09550  ? 91   GLN A C   1 
ATOM   119  O O   . GLN A 1 10  ? 9.68179   -27.45321 -14.84753 1.000 8.96640  ? 91   GLN A O   1 
ATOM   120  C CB  A GLN A 1 10  ? 8.10413   -29.51787 -16.43483 0.504 9.97068  ? 91   GLN A CB  1 
ATOM   121  C CB  B GLN A 1 10  ? 8.11460   -29.53486 -16.53028 0.496 10.08704 ? 91   GLN A CB  1 
ATOM   122  C CG  A GLN A 1 10  ? 7.71587   -30.63876 -17.38304 0.504 10.97472 ? 91   GLN A CG  1 
ATOM   123  C CG  B GLN A 1 10  ? 6.86828   -28.71292 -16.76861 0.496 11.12604 ? 91   GLN A CG  1 
ATOM   124  C CD  A GLN A 1 10  ? 6.29315   -31.13336 -17.16736 0.504 12.78024 ? 91   GLN A CD  1 
ATOM   125  C CD  B GLN A 1 10  ? 6.56757   -28.47597 -18.23989 0.496 16.85729 ? 91   GLN A CD  1 
ATOM   126  O OE1 A GLN A 1 10  ? 5.59060   -30.68246 -16.26084 0.504 13.31720 ? 91   GLN A OE1 1 
ATOM   127  O OE1 B GLN A 1 10  ? 7.19800   -29.05831 -19.12152 0.496 20.99504 ? 91   GLN A OE1 1 
ATOM   128  N NE2 A GLN A 1 10  ? 5.85839   -32.06183 -18.01382 0.504 13.63742 ? 91   GLN A NE2 1 
ATOM   129  N NE2 B GLN A 1 10  ? 5.60186   -27.60513 -18.50842 0.496 21.12898 ? 91   GLN A NE2 1 
ATOM   130  N N   . ILE A 1 11  ? 9.31152   -26.36972 -16.78604 1.000 8.54542  ? 92   ILE A N   1 
ATOM   131  C CA  . ILE A 1 11  ? 9.35823   -25.05970 -16.14475 1.000 7.48595  ? 92   ILE A CA  1 
ATOM   132  C C   . ILE A 1 11  ? 8.03469   -24.79348 -15.43945 1.000 6.62341  ? 92   ILE A C   1 
ATOM   133  O O   . ILE A 1 11  ? 6.95924   -24.87652 -16.04523 1.000 9.21954  ? 92   ILE A O   1 
ATOM   134  C CB  . ILE A 1 11  ? 9.66987   -23.94086 -17.15103 1.000 8.37704  ? 92   ILE A CB  1 
ATOM   135  C CG1 . ILE A 1 11  ? 10.97874  -24.19622 -17.90435 1.000 9.03051  ? 92   ILE A CG1 1 
ATOM   136  C CG2 . ILE A 1 11  ? 9.72851   -22.60325 -16.40867 1.000 8.84475  ? 92   ILE A CG2 1 
ATOM   137  C CD1 . ILE A 1 11  ? 11.10650  -23.34564 -19.14775 1.000 9.90159  ? 92   ILE A CD1 1 
ATOM   138  N N   . PHE A 1 12  ? 8.11356   -24.47288 -14.15790 1.000 7.03125  ? 93   PHE A N   1 
ATOM   139  C CA  . PHE A 1 12  ? 6.94874   -24.08624 -13.37491 1.000 7.34809  ? 93   PHE A CA  1 
ATOM   140  C C   . PHE A 1 12  ? 6.49506   -22.69312 -13.80586 1.000 6.87232  ? 93   PHE A C   1 
ATOM   141  O O   . PHE A 1 12  ? 7.27828   -21.73787 -13.77922 1.000 7.87526  ? 93   PHE A O   1 
ATOM   142  C CB  . PHE A 1 12  ? 7.33626   -24.10635 -11.89788 1.000 8.36938  ? 93   PHE A CB  1 
ATOM   143  C CG  . PHE A 1 12  ? 6.21816   -23.76190 -10.96402 1.000 8.02909  ? 93   PHE A CG  1 
ATOM   144  C CD1 . PHE A 1 12  ? 5.21775   -24.67116 -10.69988 1.000 9.64193  ? 93   PHE A CD1 1 
ATOM   145  C CD2 . PHE A 1 12  ? 6.19086   -22.53755 -10.31716 1.000 9.41952  ? 93   PHE A CD2 1 
ATOM   146  C CE1 . PHE A 1 12  ? 4.18539   -24.35349 -9.82763  1.000 10.78476 ? 93   PHE A CE1 1 
ATOM   147  C CE2 . PHE A 1 12  ? 5.17110   -22.22124 -9.44358  1.000 10.79390 ? 93   PHE A CE2 1 
ATOM   148  C CZ  . PHE A 1 12  ? 4.17027   -23.13031 -9.20337  1.000 10.66141 ? 93   PHE A CZ  1 
ATOM   149  N N   . LEU A 1 13  ? 5.23969   -22.56637 -14.22423 1.000 7.55059  ? 94   LEU A N   1 
ATOM   150  C CA  . LEU A 1 13  ? 4.74376   -21.27827 -14.69610 1.000 7.60511  ? 94   LEU A CA  1 
ATOM   151  C C   . LEU A 1 13  ? 4.57148   -20.31892 -13.52793 1.000 8.07445  ? 94   LEU A C   1 
ATOM   152  O O   . LEU A 1 13  ? 4.16909   -20.71994 -12.43165 1.000 9.62160  ? 94   LEU A O   1 
ATOM   153  C CB  . LEU A 1 13  ? 3.40457   -21.47218 -15.40293 1.000 8.36487  ? 94   LEU A CB  1 
ATOM   154  C CG  . LEU A 1 13  ? 3.55494   -22.15953 -16.75922 1.000 8.50213  ? 94   LEU A CG  1 
ATOM   155  C CD1 . LEU A 1 13  ? 2.20265   -22.62592 -17.25853 1.000 11.11264 ? 94   LEU A CD1 1 
ATOM   156  C CD2 . LEU A 1 13  ? 4.21138   -21.22980 -17.77037 1.000 11.11318 ? 94   LEU A CD2 1 
ATOM   157  N N   . SER A 1 14  ? 4.85754   -19.04376 -13.76669 1.000 7.37708  ? 95   SER A N   1 
ATOM   158  C CA  . SER A 1 14  ? 4.77257   -18.05413 -12.69857 1.000 7.52144  ? 95   SER A CA  1 
ATOM   159  C C   . SER A 1 14  ? 3.33264   -17.84944 -12.25146 1.000 6.78862  ? 95   SER A C   1 
ATOM   160  O O   . SER A 1 14  ? 2.51395   -17.35909 -13.04276 1.000 7.28117  ? 95   SER A O   1 
ATOM   161  C CB  . SER A 1 14  ? 5.29310   -16.71402 -13.18333 1.000 7.23690  ? 95   SER A CB  1 
ATOM   162  O OG  . SER A 1 14  ? 5.03381   -15.71772 -12.20574 1.000 7.62723  ? 95   SER A OG  1 
ATOM   163  N N   . PRO A 1 15  ? 2.98973   -18.13855 -10.99569 1.000 7.71864  ? 96   PRO A N   1 
ATOM   164  C CA  . PRO A 1 15  ? 1.62516   -17.82169 -10.54226 1.000 8.73838  ? 96   PRO A CA  1 
ATOM   165  C C   . PRO A 1 15  ? 1.38172   -16.33093 -10.41080 1.000 7.91839  ? 96   PRO A C   1 
ATOM   166  O O   . PRO A 1 15  ? 0.23804   -15.86731 -10.53077 1.000 8.54176  ? 96   PRO A O   1 
ATOM   167  C CB  . PRO A 1 15  ? 1.52071   -18.54179 -9.18941  1.000 9.00436  ? 96   PRO A CB  1 
ATOM   168  C CG  . PRO A 1 15  ? 2.62596   -19.56945 -9.21256  1.000 9.28958  ? 96   PRO A CG  1 
ATOM   169  C CD  . PRO A 1 15  ? 3.72654   -18.92506 -9.99461  1.000 7.83537  ? 96   PRO A CD  1 
ATOM   170  N N   . TYR A 1 16  ? 2.43633   -15.56924 -10.13881 1.000 8.43067  ? 97   TYR A N   1 
ATOM   171  C CA  . TYR A 1 16  ? 2.31996   -14.12538 -9.99374  1.000 8.21035  ? 97   TYR A CA  1 
ATOM   172  C C   . TYR A 1 16  ? 1.95024   -13.48407 -11.32405 1.000 7.09752  ? 97   TYR A C   1 
ATOM   173  O O   . TYR A 1 16  ? 0.99915   -12.69455 -11.40902 1.000 7.88111  ? 97   TYR A O   1 
ATOM   174  C CB  . TYR A 1 16  ? 3.65068   -13.58912 -9.47382  1.000 9.17862  ? 97   TYR A CB  1 
ATOM   175  C CG  . TYR A 1 16  ? 3.68945   -12.12216 -9.12834  1.000 7.81046  ? 97   TYR A CG  1 
ATOM   176  C CD1 . TYR A 1 16  ? 3.96671   -11.17313 -10.09824 1.000 8.75510  ? 97   TYR A CD1 1 
ATOM   177  C CD2 . TYR A 1 16  ? 3.50981   -11.69189 -7.81771  1.000 8.58251  ? 97   TYR A CD2 1 
ATOM   178  C CE1 . TYR A 1 16  ? 4.05023   -9.83660  -9.78516  1.000 8.74451  ? 97   TYR A CE1 1 
ATOM   179  C CE2 . TYR A 1 16  ? 3.57657   -10.35392 -7.49840  1.000 8.34612  ? 97   TYR A CE2 1 
ATOM   180  C CZ  . TYR A 1 16  ? 3.85274   -9.43006  -8.48180  1.000 8.82588  ? 97   TYR A CZ  1 
ATOM   181  O OH  . TYR A 1 16  ? 3.94487   -8.09865  -8.13679  1.000 9.41449  ? 97   TYR A OH  1 
ATOM   182  N N   . TYR A 1 17  ? 2.67847   -13.83864 -12.38626 1.000 7.15151  ? 98   TYR A N   1 
ATOM   183  C CA  . TYR A 1 17  ? 2.33004   -13.34772 -13.71346 1.000 7.06207  ? 98   TYR A CA  1 
ATOM   184  C C   . TYR A 1 17  ? 0.99205   -13.90770 -14.17055 1.000 7.11807  ? 98   TYR A C   1 
ATOM   185  O O   . TYR A 1 17  ? 0.20832   -13.19513 -14.80314 1.000 7.71103  ? 98   TYR A O   1 
ATOM   186  C CB  . TYR A 1 17  ? 3.42618   -13.71706 -14.70430 1.000 7.37138  ? 98   TYR A CB  1 
ATOM   187  C CG  . TYR A 1 17  ? 3.41206   -12.97239 -16.02244 1.000 7.01252  ? 98   TYR A CG  1 
ATOM   188  C CD1 . TYR A 1 17  ? 3.33185   -11.58426 -16.07199 1.000 7.10895  ? 98   TYR A CD1 1 
ATOM   189  C CD2 . TYR A 1 17  ? 3.54241   -13.65770 -17.21904 1.000 7.29571  ? 98   TYR A CD2 1 
ATOM   190  C CE1 . TYR A 1 17  ? 3.36906   -10.90890 -17.28394 1.000 7.26265  ? 98   TYR A CE1 1 
ATOM   191  C CE2 . TYR A 1 17  ? 3.58208   -12.99656 -18.42826 1.000 7.80957  ? 98   TYR A CE2 1 
ATOM   192  C CZ  . TYR A 1 17  ? 3.49381   -11.62140 -18.45930 1.000 7.15465  ? 98   TYR A CZ  1 
ATOM   193  O OH  . TYR A 1 17  ? 3.54012   -10.99148 -19.68049 1.000 8.31147  ? 98   TYR A OH  1 
ATOM   194  N N   . ALA A 1 18  ? 0.70167   -15.17312 -13.85523 1.000 7.05561  ? 99   ALA A N   1 
ATOM   195  C CA  . ALA A 1 18  ? -0.57429  -15.74686 -14.26579 1.000 8.21506  ? 99   ALA A CA  1 
ATOM   196  C C   . ALA A 1 18  ? -1.73567  -14.95858 -13.68358 1.000 7.83189  ? 99   ALA A C   1 
ATOM   197  O O   . ALA A 1 18  ? -2.74783  -14.74671 -14.35860 1.000 8.53983  ? 99   ALA A O   1 
ATOM   198  C CB  . ALA A 1 18  ? -0.66730  -17.20955 -13.83241 1.000 9.16708  ? 99   ALA A CB  1 
ATOM   199  N N   . ASN A 1 19  ? -1.60577  -14.51980 -12.43097 1.000 8.02670  ? 100  ASN A N   1 
ATOM   200  C CA  . ASN A 1 19  ? -2.65733  -13.73274 -11.80497 1.000 8.08605  ? 100  ASN A CA  1 
ATOM   201  C C   . ASN A 1 19  ? -2.84348  -12.40621 -12.52892 1.000 8.18351  ? 100  ASN A C   1 
ATOM   202  O O   . ASN A 1 19  ? -3.97830  -11.98994 -12.80235 1.000 8.46021  ? 100  ASN A O   1 
ATOM   203  C CB  . ASN A 1 19  ? -2.32348  -13.51696 -10.33172 1.000 10.04097 ? 100  ASN A CB  1 
ATOM   204  C CG  . ASN A 1 19  ? -3.21866  -12.49461 -9.67842  1.000 14.43475 ? 100  ASN A CG  1 
ATOM   205  O OD1 . ASN A 1 19  ? -4.33345  -12.80939 -9.25785  1.000 25.06888 ? 100  ASN A OD1 1 
ATOM   206  N ND2 . ASN A 1 19  ? -2.74280  -11.25907 -9.59154  1.000 17.88322 ? 100  ASN A ND2 1 
ATOM   207  N N   . GLU A 1 20  ? -1.73774  -11.73649 -12.87029 1.000 7.63651  ? 101  GLU A N   1 
ATOM   208  C CA  . GLU A 1 20  ? -1.82561  -10.48207 -13.61018 1.000 8.43582  ? 101  GLU A CA  1 
ATOM   209  C C   . GLU A 1 20  ? -2.44799  -10.69464 -14.98081 1.000 7.32185  ? 101  GLU A C   1 
ATOM   210  O O   . GLU A 1 20  ? -3.30286  -9.90843  -15.41089 1.000 8.06886  ? 101  GLU A O   1 
ATOM   211  C CB  . GLU A 1 20  ? -0.42837  -9.88062  -13.76023 1.000 7.97088  ? 101  GLU A CB  1 
ATOM   212  C CG  . GLU A 1 20  ? 0.16120   -9.40268  -12.44382 1.000 9.42933  ? 101  GLU A CG  1 
ATOM   213  C CD  . GLU A 1 20  ? 1.54858   -8.82915  -12.59491 1.000 8.14143  ? 101  GLU A CD  1 
ATOM   214  O OE1 . GLU A 1 20  ? 2.37170   -9.47682  -13.28296 1.000 7.96642  ? 101  GLU A OE1 1 
ATOM   215  O OE2 . GLU A 1 20  ? 1.81181   -7.73898  -12.03520 1.000 8.69270  ? 101  GLU A OE2 1 
ATOM   216  N N   . VAL A 1 21  ? -2.02660  -11.74666 -15.68351 1.000 7.64754  ? 102  VAL A N   1 
ATOM   217  C CA  . VAL A 1 21  ? -2.47647  -11.97692 -17.04911 1.000 7.66964  ? 102  VAL A CA  1 
ATOM   218  C C   . VAL A 1 21  ? -3.95094  -12.34923 -17.07959 1.000 7.76400  ? 102  VAL A C   1 
ATOM   219  O O   . VAL A 1 21  ? -4.69786  -11.88295 -17.94963 1.000 7.87992  ? 102  VAL A O   1 
ATOM   220  C CB  . VAL A 1 21  ? -1.60140  -13.05225 -17.71262 1.000 7.46272  ? 102  VAL A CB  1 
ATOM   221  C CG1 . VAL A 1 21  ? -2.23921  -13.55971 -18.99154 1.000 9.14424  ? 102  VAL A CG1 1 
ATOM   222  C CG2 . VAL A 1 21  ? -0.20276  -12.50650 -17.97588 1.000 9.10488  ? 102  VAL A CG2 1 
ATOM   223  N N   . ALA A 1 22  ? -4.39940  -13.19057 -16.14566 1.000 8.14144  ? 103  ALA A N   1 
ATOM   224  C CA  . ALA A 1 22  ? -5.80404  -13.58167 -16.14656 1.000 9.23144  ? 103  ALA A CA  1 
ATOM   225  C C   . ALA A 1 22  ? -6.69644  -12.37230 -15.92838 1.000 9.26569  ? 103  ALA A C   1 
ATOM   226  O O   . ALA A 1 22  ? -7.72363  -12.21291 -16.60456 1.000 9.92878  ? 103  ALA A O   1 
ATOM   227  C CB  . ALA A 1 22  ? -6.06540  -14.63200 -15.07118 1.000 11.30974 ? 103  ALA A CB  1 
ATOM   228  N N   . ALA A 1 23  ? -6.32251  -11.50876 -14.98596 1.000 8.99336  ? 104  ALA A N   1 
ATOM   229  C CA  . ALA A 1 23  ? -7.11481  -10.31293 -14.73448 1.000 9.88505  ? 104  ALA A CA  1 
ATOM   230  C C   . ALA A 1 23  ? -7.06259  -9.37392  -15.92822 1.000 9.20440  ? 104  ALA A C   1 
ATOM   231  O O   . ALA A 1 23  ? -8.07700  -8.77361  -16.30586 1.000 10.11269 ? 104  ALA A O   1 
ATOM   232  C CB  . ALA A 1 23  ? -6.61565  -9.61464  -13.47272 1.000 12.18355 ? 104  ALA A CB  1 
ATOM   233  N N   . ALA A 1 24  ? -5.89222  -9.26931  -16.55813 1.000 8.27561  ? 105  ALA A N   1 
ATOM   234  C CA  . ALA A 1 24  ? -5.74075  -8.40706  -17.72051 1.000 7.86821  ? 105  ALA A CA  1 
ATOM   235  C C   . ALA A 1 24  ? -6.58091  -8.89959  -18.88743 1.000 8.48066  ? 105  ALA A C   1 
ATOM   236  O O   . ALA A 1 24  ? -7.21394  -8.09716  -19.58420 1.000 8.77503  ? 105  ALA A O   1 
ATOM   237  C CB  . ALA A 1 24  ? -4.27223  -8.34805  -18.12856 1.000 8.93213  ? 105  ALA A CB  1 
ATOM   238  N N   . ALA A 1 25  ? -6.57944  -10.21250 -19.13087 1.000 8.96894  ? 106  ALA A N   1 
ATOM   239  C CA  . ALA A 1 25  ? -7.29563  -10.75095 -20.28361 1.000 8.89729  ? 106  ALA A CA  1 
ATOM   240  C C   . ALA A 1 25  ? -8.79315  -10.48527 -20.18895 1.000 9.08875  ? 106  ALA A C   1 
ATOM   241  O O   . ALA A 1 25  ? -9.45041  -10.26475 -21.21323 1.000 9.65530  ? 106  ALA A O   1 
ATOM   242  C CB  . ALA A 1 25  ? -7.01660  -12.24695 -20.43069 1.000 9.66010  ? 106  ALA A CB  1 
ATOM   243  N N   A LYS A 1 26  ? -9.35460  -10.52547 -18.98126 0.831 9.06633  ? 107  LYS A N   1 
ATOM   244  N N   B LYS A 1 26  ? -9.33460  -10.47254 -18.96518 0.169 9.22593  ? 107  LYS A N   1 
ATOM   245  C CA  A LYS A 1 26  ? -10.78575 -10.30251 -18.81563 0.831 9.62256  ? 107  LYS A CA  1 
ATOM   246  C CA  B LYS A 1 26  ? -10.75624 -10.20863 -18.76139 0.169 9.92845  ? 107  LYS A CA  1 
ATOM   247  C C   A LYS A 1 26  ? -11.18677 -8.87376  -19.16211 0.831 9.06940  ? 107  LYS A C   1 
ATOM   248  C C   B LYS A 1 26  ? -11.15189 -8.84887  -19.31869 0.169 9.42682  ? 107  LYS A C   1 
ATOM   249  O O   A LYS A 1 26  ? -12.37662 -8.61698  -19.40895 0.831 9.41284  ? 107  LYS A O   1 
ATOM   250  O O   B LYS A 1 26  ? -12.23419 -8.69542  -19.89915 0.169 11.29374 ? 107  LYS A O   1 
ATOM   251  C CB  A LYS A 1 26  ? -11.18468 -10.59397 -17.37163 0.831 11.06410 ? 107  LYS A CB  1 
ATOM   252  C CB  B LYS A 1 26  ? -11.07601 -10.25094 -17.26713 0.169 13.15950 ? 107  LYS A CB  1 
ATOM   253  C CG  A LYS A 1 26  ? -11.39006 -12.05672 -17.05623 0.831 13.66341 ? 107  LYS A CG  1 
ATOM   254  C CG  B LYS A 1 26  ? -11.57233 -11.58802 -16.75140 0.169 15.41841 ? 107  LYS A CG  1 
ATOM   255  C CD  A LYS A 1 26  ? -11.53643 -12.26736 -15.55171 0.831 19.03681 ? 107  LYS A CD  1 
ATOM   256  C CD  B LYS A 1 26  ? -10.84118 -11.97811 -15.47449 0.169 17.93700 ? 107  LYS A CD  1 
ATOM   257  C CE  A LYS A 1 26  ? -11.43064 -13.73698 -15.17882 0.831 26.86358 ? 107  LYS A CE  1 
ATOM   258  C CE  B LYS A 1 26  ? -10.99642 -13.45947 -15.17228 0.169 20.84124 ? 107  LYS A CE  1 
ATOM   259  N NZ  A LYS A 1 26  ? -12.68335 -14.47506 -15.49879 0.831 27.82911 ? 107  LYS A NZ  1 
ATOM   260  N NZ  B LYS A 1 26  ? -9.67962  -14.13830 -15.02633 0.169 19.58749 ? 107  LYS A NZ  1 
ATOM   261  N N   A GLN A 1 27  ? -10.22935 -7.93630  -19.16586 0.831 9.80082  ? 108  GLN A N   1 
ATOM   262  N N   B GLN A 1 27  ? -10.29409 -7.84449  -19.13748 0.169 10.27423 ? 108  GLN A N   1 
ATOM   263  C CA  A GLN A 1 27  ? -10.49309 -6.54156  -19.50635 0.831 10.82748 ? 108  GLN A CA  1 
ATOM   264  C CA  B GLN A 1 27  ? -10.62008 -6.49180  -19.56375 0.169 11.13847 ? 108  GLN A CA  1 
ATOM   265  C C   A GLN A 1 27  ? -10.21066 -6.20462  -20.96132 0.831 10.06523 ? 108  GLN A C   1 
ATOM   266  C C   B GLN A 1 27  ? -10.44021 -6.28606  -21.05729 0.169 10.47717 ? 108  GLN A C   1 
ATOM   267  O O   A GLN A 1 27  ? -10.46988 -5.06731  -21.37984 0.831 13.09515 ? 108  GLN A O   1 
ATOM   268  O O   B GLN A 1 27  ? -10.99541 -5.32741  -21.60615 0.169 7.60643  ? 108  GLN A O   1 
ATOM   269  C CB  A GLN A 1 27  ? -9.69657  -5.56987  -18.62383 0.831 13.55292 ? 108  GLN A CB  1 
ATOM   270  C CB  B GLN A 1 27  ? -9.75030  -5.47820  -18.82226 0.169 13.57961 ? 108  GLN A CB  1 
ATOM   271  C CG  A GLN A 1 27  ? -9.84203  -5.76068  -17.13572 0.831 13.54395 ? 108  GLN A CG  1 
ATOM   272  C CG  B GLN A 1 27  ? -9.21703  -5.97545  -17.50043 0.169 14.30417 ? 108  GLN A CG  1 
ATOM   273  C CD  A GLN A 1 27  ? -8.69887  -5.12508  -16.37206 0.831 20.02238 ? 108  GLN A CD  1 
ATOM   274  C CD  B GLN A 1 27  ? -8.15197  -5.06473  -16.93376 0.169 16.23073 ? 108  GLN A CD  1 
ATOM   275  O OE1 A GLN A 1 27  ? -7.91430  -5.81291  -15.71965 0.831 21.18249 ? 108  GLN A OE1 1 
ATOM   276  O OE1 B GLN A 1 27  ? -7.24788  -5.51279  -16.23232 0.169 17.59497 ? 108  GLN A OE1 1 
ATOM   277  N NE2 A GLN A 1 27  ? -8.58497  -3.80381  -16.46816 0.831 18.17807 ? 108  GLN A NE2 1 
ATOM   278  N NE2 B GLN A 1 27  ? -8.25523  -3.77540  -17.23266 0.169 11.83218 ? 108  GLN A NE2 1 
ATOM   279  N N   . ILE A 1 28  ? -9.67450  -7.14450  -21.72670 1.000 9.84364  ? 109  ILE A N   1 
ATOM   280  C CA  . ILE A 1 28  ? -9.45719  -6.95226  -23.15187 1.000 10.02852 ? 109  ILE A CA  1 
ATOM   281  C C   . ILE A 1 28  ? -10.76524 -7.27367  -23.85712 1.000 10.11522 ? 109  ILE A C   1 
ATOM   282  O O   . ILE A 1 28  ? -11.28746 -8.38788  -23.74510 1.000 10.70515 ? 109  ILE A O   1 
ATOM   283  C CB  . ILE A 1 28  ? -8.29349  -7.81740  -23.63991 1.000 9.01147  ? 109  ILE A CB  1 
ATOM   284  C CG1 . ILE A 1 28  ? -6.99953  -7.30414  -23.00066 1.000 9.91473  ? 109  ILE A CG1 1 
ATOM   285  C CG2 . ILE A 1 28  ? -8.21880  -7.81335  -25.14988 1.000 10.99685 ? 109  ILE A CG2 1 
ATOM   286  C CD1 . ILE A 1 28  ? -5.78656  -8.12370  -23.31772 1.000 10.88600 ? 109  ILE A CD1 1 
ATOM   287  N N   . THR A 1 29  ? -11.32806 -6.27619  -24.54306 1.000 10.09601 ? 110  THR A N   1 
ATOM   288  C CA  . THR A 1 29  ? -12.72357 -6.36907  -24.95449 1.000 10.83219 ? 110  THR A CA  1 
ATOM   289  C C   . THR A 1 29  ? -12.89896 -7.23622  -26.19199 1.000 11.99761 ? 110  THR A C   1 
ATOM   290  O O   . THR A 1 29  ? -13.90689 -7.94156  -26.31065 1.000 14.23700 ? 110  THR A O   1 
ATOM   291  C CB  . THR A 1 29  ? -13.34064 -4.97803  -25.13984 1.000 11.16636 ? 110  THR A CB  1 
ATOM   292  O OG1 . THR A 1 29  ? -12.71901 -4.31134  -26.24674 1.000 14.93817 ? 110  THR A OG1 1 
ATOM   293  C CG2 . THR A 1 29  ? -13.16652 -4.14206  -23.88682 1.000 13.65557 ? 110  THR A CG2 1 
ATOM   294  N N   . ASP A 1 30  ? -11.95055 -7.20162  -27.12153 1.000 13.34160 ? 111  ASP A N   1 
ATOM   295  C CA  . ASP A 1 30  ? -12.05562 -8.05907  -28.29922 1.000 15.35163 ? 111  ASP A CA  1 
ATOM   296  C C   . ASP A 1 30  ? -11.85240 -9.51129  -27.88673 1.000 12.73489 ? 111  ASP A C   1 
ATOM   297  O O   . ASP A 1 30  ? -10.82312 -9.83195  -27.27843 1.000 12.94036 ? 111  ASP A O   1 
ATOM   298  C CB  . ASP A 1 30  ? -11.02337 -7.66570  -29.34637 1.000 18.33556 ? 111  ASP A CB  1 
ATOM   299  C CG  . ASP A 1 30  ? -11.13250 -8.50341  -30.60356 1.000 22.86116 ? 111  ASP A CG  1 
ATOM   300  O OD1 . ASP A 1 30  ? -10.34789 -9.46328  -30.74758 1.000 23.02123 ? 111  ASP A OD1 1 
ATOM   301  O OD2 . ASP A 1 30  ? -12.00134 -8.20089  -31.44947 1.000 28.02250 ? 111  ASP A OD2 1 
ATOM   302  N N   . PRO A 1 31  ? -12.79358 -10.41264 -28.18258 1.000 13.68987 ? 112  PRO A N   1 
ATOM   303  C CA  . PRO A 1 31  ? -12.67772 -11.78966 -27.66856 1.000 15.88563 ? 112  PRO A CA  1 
ATOM   304  C C   . PRO A 1 31  ? -11.46516 -12.52836 -28.19738 1.000 13.17255 ? 112  PRO A C   1 
ATOM   305  O O   . PRO A 1 31  ? -10.83592 -13.29922 -27.46069 1.000 14.32816 ? 112  PRO A O   1 
ATOM   306  C CB  . PRO A 1 31  ? -13.97444 -12.45486 -28.15366 1.000 21.13093 ? 112  PRO A CB  1 
ATOM   307  C CG  . PRO A 1 31  ? -14.88740 -11.32999 -28.49341 1.000 24.26843 ? 112  PRO A CG  1 
ATOM   308  C CD  . PRO A 1 31  ? -14.03166 -10.20631 -28.95097 1.000 17.64369 ? 112  PRO A CD  1 
ATOM   309  N N   . THR A 1 32  ? -11.14409 -12.33699 -29.47634 1.000 15.06232 ? 113  THR A N   1 
ATOM   310  C CA  . THR A 1 32  ? -10.00454 -13.02859 -30.06465 1.000 16.01104 ? 113  THR A CA  1 
ATOM   311  C C   . THR A 1 32  ? -8.70553  -12.57618 -29.41249 1.000 14.76347 ? 113  THR A C   1 
ATOM   312  O O   . THR A 1 32  ? -7.85188  -13.39872 -29.06059 1.000 14.93007 ? 113  THR A O   1 
ATOM   313  C CB  . THR A 1 32  ? -9.98726  -12.78320 -31.57421 1.000 21.83352 ? 113  THR A CB  1 
ATOM   314  O OG1 . THR A 1 32  ? -11.20328 -13.28190 -32.14583 1.000 24.52769 ? 113  THR A OG1 1 
ATOM   315  C CG2 . THR A 1 32  ? -8.81066  -13.48064 -32.22455 1.000 24.01304 ? 113  THR A CG2 1 
ATOM   316  N N   . LEU A 1 33  ? -8.54916  -11.26667 -29.22397 1.000 12.72041 ? 114  LEU A N   1 
ATOM   317  C CA  . LEU A 1 33  ? -7.36010  -10.76722 -28.54803 1.000 12.28548 ? 114  LEU A CA  1 
ATOM   318  C C   . LEU A 1 33  ? -7.33237  -11.21507 -27.09269 1.000 9.61816  ? 114  LEU A C   1 
ATOM   319  O O   . LEU A 1 33  ? -6.26418  -11.51948 -26.55037 1.000 9.97074  ? 114  LEU A O   1 
ATOM   320  C CB  . LEU A 1 33  ? -7.31273  -9.24687  -28.65652 1.000 12.13215 ? 114  LEU A CB  1 
ATOM   321  C CG  . LEU A 1 33  ? -5.99383  -8.59415  -28.25664 1.000 14.10256 ? 114  LEU A CG  1 
ATOM   322  C CD1 . LEU A 1 33  ? -4.87599  -9.07623  -29.15960 1.000 15.12933 ? 114  LEU A CD1 1 
ATOM   323  C CD2 . LEU A 1 33  ? -6.12160  -7.09053  -28.35250 1.000 14.26152 ? 114  LEU A CD2 1 
ATOM   324  N N   . SER A 1 34  ? -8.49894  -11.26510 -26.44525 1.000 10.24395 ? 115  SER A N   1 
ATOM   325  C CA  . SER A 1 34  ? -8.55407  -11.67522 -25.04804 1.000 9.07328  ? 115  SER A CA  1 
ATOM   326  C C   . SER A 1 34  ? -8.07007  -13.11209 -24.86248 1.000 8.90203  ? 115  SER A C   1 
ATOM   327  O O   . SER A 1 34  ? -7.32645  -13.40048 -23.91746 1.000 9.18835  ? 115  SER A O   1 
ATOM   328  C CB  . SER A 1 34  ? -9.97669  -11.50100 -24.52208 1.000 9.88709  ? 115  SER A CB  1 
ATOM   329  O OG  . SER A 1 34  ? -10.09951 -11.99893 -23.20583 1.000 10.39159 ? 115  SER A OG  1 
ATOM   330  N N   . SER A 1 35  ? -8.47766  -14.02981 -25.74928 1.000 10.24791 ? 116  SER A N   1 
ATOM   331  C CA  A SER A 1 35  ? -8.01401  -15.40568 -25.60707 0.594 11.23213 ? 116  SER A CA  1 
ATOM   332  C CA  B SER A 1 35  ? -8.01970  -15.41517 -25.65595 0.406 11.28935 ? 116  SER A CA  1 
ATOM   333  C C   . SER A 1 35  ? -6.51398  -15.51434 -25.86238 1.000 9.85797  ? 116  SER A C   1 
ATOM   334  O O   . SER A 1 35  ? -5.82644  -16.27858 -25.17525 1.000 10.36788 ? 116  SER A O   1 
ATOM   335  C CB  A SER A 1 35  ? -8.81367  -16.35316 -26.49963 0.594 13.05214 ? 116  SER A CB  1 
ATOM   336  C CB  B SER A 1 35  ? -8.74612  -16.28797 -26.68035 0.406 12.70854 ? 116  SER A CB  1 
ATOM   337  O OG  A SER A 1 35  ? -8.58141  -16.08653 -27.86476 0.594 13.83624 ? 116  SER A OG  1 
ATOM   338  O OG  B SER A 1 35  ? -10.13523 -16.01836 -26.70534 0.406 14.89392 ? 116  SER A OG  1 
ATOM   339  N N   A LYS A 1 36  ? -6.00153  -14.76387 -26.84195 0.635 9.35867  ? 117  LYS A N   1 
ATOM   340  N N   B LYS A 1 36  ? -5.97383  -14.75547 -26.81612 0.365 9.40925  ? 117  LYS A N   1 
ATOM   341  C CA  A LYS A 1 36  ? -4.55933  -14.70722 -27.06177 0.635 9.12542  ? 117  LYS A CA  1 
ATOM   342  C CA  B LYS A 1 36  ? -4.52819  -14.78883 -27.01246 0.365 9.28102  ? 117  LYS A CA  1 
ATOM   343  C C   A LYS A 1 36  ? -3.84925  -14.21392 -25.80928 0.635 9.26799  ? 117  LYS A C   1 
ATOM   344  C C   B LYS A 1 36  ? -3.79410  -14.17570 -25.82674 0.365 9.27561  ? 117  LYS A C   1 
ATOM   345  O O   A LYS A 1 36  ? -2.84276  -14.78696 -25.37627 0.635 8.78346  ? 117  LYS A O   1 
ATOM   346  O O   B LYS A 1 36  ? -2.70700  -14.63503 -25.45793 0.365 10.02458 ? 117  LYS A O   1 
ATOM   347  C CB  A LYS A 1 36  ? -4.24912  -13.78005 -28.23679 0.635 10.56509 ? 117  LYS A CB  1 
ATOM   348  C CB  B LYS A 1 36  ? -4.13209  -14.12829 -28.33114 0.365 10.55949 ? 117  LYS A CB  1 
ATOM   349  C CG  A LYS A 1 36  ? -4.50380  -14.38573 -29.60843 0.635 12.16212 ? 117  LYS A CG  1 
ATOM   350  C CG  B LYS A 1 36  ? -4.82590  -14.71583 -29.54699 0.365 12.33950 ? 117  LYS A CG  1 
ATOM   351  C CD  A LYS A 1 36  ? -4.26202  -13.36333 -30.70951 0.635 16.78341 ? 117  LYS A CD  1 
ATOM   352  C CD  B LYS A 1 36  ? -4.81110  -13.74858 -30.71853 0.365 17.07012 ? 117  LYS A CD  1 
ATOM   353  C CE  A LYS A 1 36  ? -4.52568  -13.94720 -32.09009 0.635 18.42451 ? 117  LYS A CE  1 
ATOM   354  C CE  B LYS A 1 36  ? -5.17578  -14.45575 -32.01283 0.365 19.41569 ? 117  LYS A CE  1 
ATOM   355  N NZ  A LYS A 1 36  ? -5.54350  -15.03584 -32.06200 0.635 23.03818 ? 117  LYS A NZ  1 
ATOM   356  N NZ  B LYS A 1 36  ? -5.06627  -13.57016 -33.20440 0.365 16.28264 ? 117  LYS A NZ  1 
ATOM   357  N N   . ALA A 1 37  ? -4.37580  -13.14810 -25.20717 1.000 7.90526  ? 118  ALA A N   1 
ATOM   358  C CA  . ALA A 1 37  ? -3.77029  -12.58442 -24.00693 1.000 8.59039  ? 118  ALA A CA  1 
ATOM   359  C C   . ALA A 1 37  ? -3.75451  -13.59016 -22.86568 1.000 8.29426  ? 118  ALA A C   1 
ATOM   360  O O   . ALA A 1 37  ? -2.74215  -13.73614 -22.17311 1.000 8.64786  ? 118  ALA A O   1 
ATOM   361  C CB  . ALA A 1 37  ? -4.53109  -11.32999 -23.59011 1.000 8.91278  ? 118  ALA A CB  1 
ATOM   362  N N   . ALA A 1 38  ? -4.86977  -14.29358 -22.65072 1.000 7.80224  ? 119  ALA A N   1 
ATOM   363  C CA  . ALA A 1 38  ? -4.92824  -15.26282 -21.56395 1.000 9.06665  ? 119  ALA A CA  1 
ATOM   364  C C   . ALA A 1 38  ? -3.88535  -16.35626 -21.74087 1.000 7.49593  ? 119  ALA A C   1 
ATOM   365  O O   . ALA A 1 38  ? -3.35315  -16.86622 -20.74844 1.000 8.53192  ? 119  ALA A O   1 
ATOM   366  C CB  . ALA A 1 38  ? -6.32756  -15.86902 -21.48958 1.000 8.46738  ? 119  ALA A CB  1 
ATOM   367  N N   . SER A 1 39  ? -3.58215  -16.71864 -22.99103 1.000 7.88975  ? 120  SER A N   1 
ATOM   368  C CA  . SER A 1 39  ? -2.61889  -17.78238 -23.26710 1.000 8.36449  ? 120  SER A CA  1 
ATOM   369  C C   . SER A 1 39  ? -1.20585  -17.42680 -22.83190 1.000 7.86653  ? 120  SER A C   1 
ATOM   370  O O   . SER A 1 39  ? -0.37454  -18.32788 -22.68310 1.000 8.50280  ? 120  SER A O   1 
ATOM   371  C CB  . SER A 1 39  ? -2.62399  -18.14053 -24.75466 1.000 9.15702  ? 120  SER A CB  1 
ATOM   372  O OG  . SER A 1 39  ? -1.84537  -17.23737 -25.52750 1.000 9.56853  ? 120  SER A OG  1 
ATOM   373  N N   . VAL A 1 40  ? -0.92212  -16.13970 -22.62664 1.000 7.46503  ? 121  VAL A N   1 
ATOM   374  C CA  . VAL A 1 40  ? 0.39847   -15.71711 -22.17648 1.000 7.54978  ? 121  VAL A CA  1 
ATOM   375  C C   . VAL A 1 40  ? 0.74234   -16.33097 -20.82779 1.000 7.29495  ? 121  VAL A C   1 
ATOM   376  O O   . VAL A 1 40  ? 1.91968   -16.56588 -20.53280 1.000 8.08336  ? 121  VAL A O   1 
ATOM   377  C CB  . VAL A 1 40  ? 0.46206   -14.17742 -22.15860 1.000 7.41801  ? 121  VAL A CB  1 
ATOM   378  C CG1 . VAL A 1 40  ? 1.75821   -13.66625 -21.50991 1.000 8.58487  ? 121  VAL A CG1 1 
ATOM   379  C CG2 . VAL A 1 40  ? 0.31998   -13.64133 -23.56507 1.000 9.52093  ? 121  VAL A CG2 1 
ATOM   380  N N   . ALA A 1 41  ? -0.26080  -16.62351 -19.99532 1.000 7.76796  ? 122  ALA A N   1 
ATOM   381  C CA  . ALA A 1 41  ? 0.00848   -17.21262 -18.68798 1.000 7.23548  ? 122  ALA A CA  1 
ATOM   382  C C   . ALA A 1 41  ? 0.60803   -18.60646 -18.78282 1.000 7.16237  ? 122  ALA A C   1 
ATOM   383  O O   . ALA A 1 41  ? 1.10001   -19.12530 -17.77589 1.000 8.18757  ? 122  ALA A O   1 
ATOM   384  C CB  . ALA A 1 41  ? -1.28068  -17.25956 -17.87018 1.000 8.91278  ? 122  ALA A CB  1 
ATOM   385  N N   . ASN A 1 42  ? 0.57051   -19.21956 -19.96154 1.000 7.20242  ? 123  ASN A N   1 
ATOM   386  C CA  . ASN A 1 42  ? 1.14743   -20.53326 -20.18437 1.000 7.50825  ? 123  ASN A CA  1 
ATOM   387  C C   . ASN A 1 42  ? 2.54654   -20.46300 -20.76554 1.000 7.21932  ? 123  ASN A C   1 
ATOM   388  O O   . ASN A 1 42  ? 3.10970   -21.50526 -21.12090 1.000 9.23755  ? 123  ASN A O   1 
ATOM   389  C CB  . ASN A 1 42  ? 0.24931   -21.34319 -21.10934 1.000 9.66375  ? 123  ASN A CB  1 
ATOM   390  C CG  . ASN A 1 42  ? -1.12960  -21.53329 -20.53863 1.000 9.61034  ? 123  ASN A CG  1 
ATOM   391  O OD1 . ASN A 1 42  ? -1.28934  -21.85220 -19.36621 1.000 12.75401 ? 123  ASN A OD1 1 
ATOM   392  N ND2 . ASN A 1 42  ? -2.14264  -21.29268 -21.35939 1.000 13.11554 ? 123  ASN A ND2 1 
ATOM   393  N N   . ILE A 1 43  ? 3.11602   -19.27355 -20.87627 1.000 7.21780  ? 124  ILE A N   1 
ATOM   394  C CA  . ILE A 1 43  ? 4.47040   -19.08856 -21.39315 1.000 7.45964  ? 124  ILE A CA  1 
ATOM   395  C C   . ILE A 1 43  ? 5.39742   -18.87130 -20.20285 1.000 7.94755  ? 124  ILE A C   1 
ATOM   396  O O   . ILE A 1 43  ? 5.11067   -18.00473 -19.36393 1.000 7.81866  ? 124  ILE A O   1 
ATOM   397  C CB  . ILE A 1 43  ? 4.53434   -17.89315 -22.36002 1.000 8.22407  ? 124  ILE A CB  1 
ATOM   398  C CG1 . ILE A 1 43  ? 3.54770   -18.10841 -23.51166 1.000 8.79672  ? 124  ILE A CG1 1 
ATOM   399  C CG2 . ILE A 1 43  ? 5.96322   -17.67331 -22.86067 1.000 8.59337  ? 124  ILE A CG2 1 
ATOM   400  C CD1 . ILE A 1 43  ? 3.39190   -16.91424 -24.41804 1.000 10.03341 ? 124  ILE A CD1 1 
ATOM   401  N N   . PRO A 1 44  ? 6.48185   -19.62842 -20.07339 1.000 7.48500  ? 125  PRO A N   1 
ATOM   402  C CA  . PRO A 1 44  ? 7.32335   -19.48862 -18.87984 1.000 7.63545  ? 125  PRO A CA  1 
ATOM   403  C C   . PRO A 1 44  ? 8.02223   -18.13543 -18.81353 1.000 6.93135  ? 125  PRO A C   1 
ATOM   404  O O   . PRO A 1 44  ? 8.59558   -17.65565 -19.79762 1.000 7.53290  ? 125  PRO A O   1 
ATOM   405  C CB  . PRO A 1 44  ? 8.32295   -20.64099 -19.01151 1.000 9.96977  ? 125  PRO A CB  1 
ATOM   406  C CG  . PRO A 1 44  ? 8.32339   -20.99548 -20.45038 1.000 9.67029  ? 125  PRO A CG  1 
ATOM   407  C CD  . PRO A 1 44  ? 6.94609   -20.70287 -20.96707 1.000 7.94593  ? 125  PRO A CD  1 
ATOM   408  N N   . THR A 1 45  ? 7.98997   -17.53859 -17.62007 1.000 7.05713  ? 126  THR A N   1 
ATOM   409  C CA  . THR A 1 45  ? 8.62413   -16.25784 -17.33261 1.000 7.17511  ? 126  THR A CA  1 
ATOM   410  C C   . THR A 1 45  ? 9.39373   -16.35868 -16.02075 1.000 6.38731  ? 126  THR A C   1 
ATOM   411  O O   . THR A 1 45  ? 9.23276   -17.30572 -15.24010 1.000 7.35055  ? 126  THR A O   1 
ATOM   412  C CB  . THR A 1 45  ? 7.59668   -15.11470 -17.21416 1.000 7.68372  ? 126  THR A CB  1 
ATOM   413  O OG1 . THR A 1 45  ? 6.68751   -15.39585 -16.13938 1.000 7.07905  ? 126  THR A OG1 1 
ATOM   414  C CG2 . THR A 1 45  ? 6.83475   -14.90772 -18.51167 1.000 8.57625  ? 126  THR A CG2 1 
ATOM   415  N N   . PHE A 1 46  ? 10.24485  -15.36363 -15.77737 1.000 7.26898  ? 127  PHE A N   1 
ATOM   416  C CA  . PHE A 1 46  ? 10.93393  -15.22731 -14.50445 1.000 6.58749  ? 127  PHE A CA  1 
ATOM   417  C C   . PHE A 1 46  ? 10.10202  -14.37025 -13.56098 1.000 6.16357  ? 127  PHE A C   1 
ATOM   418  O O   . PHE A 1 46  ? 9.52493   -13.35797 -13.97141 1.000 6.95929  ? 127  PHE A O   1 
ATOM   419  C CB  . PHE A 1 46  ? 12.30271  -14.57578 -14.72449 1.000 6.90201  ? 127  PHE A CB  1 
ATOM   420  C CG  . PHE A 1 46  ? 13.35250  -15.54194 -15.20451 1.000 6.62563  ? 127  PHE A CG  1 
ATOM   421  C CD1 . PHE A 1 46  ? 13.29419  -16.09577 -16.47514 1.000 7.12318  ? 127  PHE A CD1 1 
ATOM   422  C CD2 . PHE A 1 46  ? 14.38563  -15.92363 -14.36169 1.000 7.09382  ? 127  PHE A CD2 1 
ATOM   423  C CE1 . PHE A 1 46  ? 14.24867  -17.01419 -16.89057 1.000 7.71685  ? 127  PHE A CE1 1 
ATOM   424  C CE2 . PHE A 1 46  ? 15.34458  -16.83671 -14.77175 1.000 7.58464  ? 127  PHE A CE2 1 
ATOM   425  C CZ  . PHE A 1 46  ? 15.27495  -17.38444 -16.03689 1.000 8.00111  ? 127  PHE A CZ  1 
ATOM   426  N N   . THR A 1 47  ? 10.03283  -14.78779 -12.30042 1.000 6.61015  ? 128  THR A N   1 
ATOM   427  C CA  . THR A 1 47  ? 9.32525   -14.04618 -11.26602 1.000 6.16876  ? 128  THR A CA  1 
ATOM   428  C C   . THR A 1 47  ? 10.35673  -13.29371 -10.43233 1.000 6.78677  ? 128  THR A C   1 
ATOM   429  O O   . THR A 1 47  ? 11.37028  -13.86738 -10.01786 1.000 7.06666  ? 128  THR A O   1 
ATOM   430  C CB  . THR A 1 47  ? 8.48174   -14.98218 -10.39563 1.000 7.07877  ? 128  THR A CB  1 
ATOM   431  O OG1 . THR A 1 47  ? 7.59108   -15.74151 -11.22171 1.000 7.00868  ? 128  THR A OG1 1 
ATOM   432  C CG2 . THR A 1 47  ? 7.65929   -14.19567 -9.39345  1.000 7.98454  ? 128  THR A CG2 1 
ATOM   433  N N   . TRP A 1 48  ? 10.11268  -12.00873 -10.21080 1.000 6.29601  ? 129  TRP A N   1 
ATOM   434  C CA  . TRP A 1 48  ? 11.11540  -11.14184 -9.61781  1.000 6.24949  ? 129  TRP A CA  1 
ATOM   435  C C   . TRP A 1 48  ? 10.94074  -11.05969 -8.11160  1.000 6.07308  ? 129  TRP A C   1 
ATOM   436  O O   . TRP A 1 48  ? 9.85048   -10.74840 -7.61017  1.000 7.24755  ? 129  TRP A O   1 
ATOM   437  C CB  . TRP A 1 48  ? 11.05215  -9.74524  -10.22514 1.000 6.60757  ? 129  TRP A CB  1 
ATOM   438  C CG  . TRP A 1 48  ? 11.47198  -9.69018  -11.65295 1.000 6.70512  ? 129  TRP A CG  1 
ATOM   439  C CD1 . TRP A 1 48  ? 10.96047  -10.41597 -12.69772 1.000 6.62016  ? 129  TRP A CD1 1 
ATOM   440  C CD2 . TRP A 1 48  ? 12.46465  -8.82242  -12.21339 1.000 6.26015  ? 129  TRP A CD2 1 
ATOM   441  N NE1 . TRP A 1 48  ? 11.59952  -10.06708 -13.86382 1.000 6.98813  ? 129  TRP A NE1 1 
ATOM   442  C CE2 . TRP A 1 48  ? 12.51237  -9.08032  -13.59419 1.000 6.23809  ? 129  TRP A CE2 1 
ATOM   443  C CE3 . TRP A 1 48  ? 13.30982  -7.84484  -11.67871 1.000 6.83913  ? 129  TRP A CE3 1 
ATOM   444  C CZ2 . TRP A 1 48  ? 13.37224  -8.40479  -14.44554 1.000 6.79896  ? 129  TRP A CZ2 1 
ATOM   445  C CZ3 . TRP A 1 48  ? 14.16204  -7.17895  -12.52469 1.000 7.13110  ? 129  TRP A CZ3 1 
ATOM   446  C CH2 . TRP A 1 48  ? 14.18814  -7.46084  -13.88971 1.000 7.58862  ? 129  TRP A CH2 1 
ATOM   447  N N   . LEU A 1 49  ? 12.02635  -11.33151 -7.39180  1.000 6.48780  ? 130  LEU A N   1 
ATOM   448  C CA  . LEU A 1 49  ? 12.06609  -11.11586 -5.95044  1.000 6.62649  ? 130  LEU A CA  1 
ATOM   449  C C   . LEU A 1 49  ? 12.58660  -9.69805  -5.71138  1.000 6.70379  ? 130  LEU A C   1 
ATOM   450  O O   . LEU A 1 49  ? 13.72265  -9.46311  -5.28959  1.000 7.73104  ? 130  LEU A O   1 
ATOM   451  C CB  . LEU A 1 49  ? 12.88525  -12.20312 -5.26594  1.000 7.34446  ? 130  LEU A CB  1 
ATOM   452  C CG  . LEU A 1 49  ? 12.46471  -13.63469 -5.63474  1.000 7.69440  ? 130  LEU A CG  1 
ATOM   453  C CD1 . LEU A 1 49  ? 13.27432  -14.63598 -4.83855  1.000 9.54366  ? 130  LEU A CD1 1 
ATOM   454  C CD2 . LEU A 1 49  ? 10.96598  -13.86418 -5.43576  1.000 8.75452  ? 130  LEU A CD2 1 
ATOM   455  N N   . ASP A 1 50  ? 11.72425  -8.73270  -6.03705  1.000 6.96377  ? 131  ASP A N   1 
ATOM   456  C CA  . ASP A 1 50  ? 12.08831  -7.32244  -6.02201  1.000 7.16717  ? 131  ASP A CA  1 
ATOM   457  C C   . ASP A 1 50  ? 11.92364  -6.68851  -4.65356  1.000 6.72104  ? 131  ASP A C   1 
ATOM   458  O O   . ASP A 1 50  ? 12.20578  -5.49576  -4.49866  1.000 8.10266  ? 131  ASP A O   1 
ATOM   459  C CB  . ASP A 1 50  ? 11.30984  -6.54028  -7.09167  1.000 7.41063  ? 131  ASP A CB  1 
ATOM   460  C CG  . ASP A 1 50  ? 9.80339   -6.56250  -6.86989  1.000 7.12554  ? 131  ASP A CG  1 
ATOM   461  O OD1 . ASP A 1 50  ? 9.25766   -7.64035  -6.55427  1.000 8.90134  ? 131  ASP A OD1 1 
ATOM   462  O OD2 . ASP A 1 50  ? 9.16846   -5.49824  -7.03724  1.000 9.46352  ? 131  ASP A OD2 1 
ATOM   463  N N   . SER A 1 51  ? 11.48657  -7.45794  -3.66318  1.000 7.70582  ? 132  SER A N   1 
ATOM   464  C CA  . SER A 1 51  ? 11.38248  -6.97888  -2.29697  1.000 8.22498  ? 132  SER A CA  1 
ATOM   465  C C   . SER A 1 51  ? 11.31212  -8.19121  -1.38250  1.000 7.27655  ? 132  SER A C   1 
ATOM   466  O O   . SER A 1 51  ? 10.99909  -9.30376  -1.82599  1.000 8.04737  ? 132  SER A O   1 
ATOM   467  C CB  . SER A 1 51  ? 10.13736  -6.11273  -2.10256  1.000 9.52844  ? 132  SER A CB  1 
ATOM   468  O OG  . SER A 1 51  ? 8.97111   -6.91079  -2.17204  1.000 11.24495 ? 132  SER A OG  1 
ATOM   469  N N   . VAL A 1 52  ? 11.56447  -7.96000  -0.08888  1.000 7.77836  ? 133  VAL A N   1 
ATOM   470  C CA  . VAL A 1 52  ? 11.45216  -9.05422  0.87692   1.000 8.67293  ? 133  VAL A CA  1 
ATOM   471  C C   . VAL A 1 52  ? 10.03290  -9.60316  0.93443   1.000 8.75136  ? 133  VAL A C   1 
ATOM   472  O O   . VAL A 1 52  ? 9.82997   -10.78130 1.26544   1.000 8.35357  ? 133  VAL A O   1 
ATOM   473  C CB  . VAL A 1 52  ? 11.96180  -8.65090  2.27591   1.000 8.60919  ? 133  VAL A CB  1 
ATOM   474  C CG1 . VAL A 1 52  ? 13.45676  -8.40064  2.25475   1.000 10.45779 ? 133  VAL A CG1 1 
ATOM   475  C CG2 . VAL A 1 52  ? 11.20574  -7.44687  2.79948   1.000 12.27029 ? 133  VAL A CG2 1 
ATOM   476  N N   . ALA A 1 53  ? 9.03368   -8.77519  0.61048   1.000 8.64860  ? 134  ALA A N   1 
ATOM   477  C CA  . ALA A 1 53  ? 7.65085   -9.24463  0.58243   1.000 8.86074  ? 134  ALA A CA  1 
ATOM   478  C C   . ALA A 1 53  ? 7.44547   -10.39713 -0.38994  1.000 8.34892  ? 134  ALA A C   1 
ATOM   479  O O   . ALA A 1 53  ? 6.48520   -11.16033 -0.23543  1.000 10.15199 ? 134  ALA A O   1 
ATOM   480  C CB  . ALA A 1 53  ? 6.70842   -8.09822  0.22369   1.000 10.40448 ? 134  ALA A CB  1 
ATOM   481  N N   . LYS A 1 54  ? 8.31891   -10.55027 -1.37951  1.000 7.87099  ? 135  LYS A N   1 
ATOM   482  C CA  . LYS A 1 54  ? 8.18278   -11.62373 -2.34893  1.000 7.98507  ? 135  LYS A CA  1 
ATOM   483  C C   . LYS A 1 54  ? 8.81308   -12.93358 -1.89041  1.000 7.88296  ? 135  LYS A C   1 
ATOM   484  O O   . LYS A 1 54  ? 8.60288   -13.96274 -2.54381  1.000 8.61822  ? 135  LYS A O   1 
ATOM   485  C CB  . LYS A 1 54  ? 8.77625   -11.20264 -3.70245  1.000 8.28518  ? 135  LYS A CB  1 
ATOM   486  C CG  . LYS A 1 54  ? 8.22904   -9.89379  -4.26292  1.000 8.55242  ? 135  LYS A CG  1 
ATOM   487  C CD  . LYS A 1 54  ? 6.71934   -9.94750  -4.49433  1.000 8.52145  ? 135  LYS A CD  1 
ATOM   488  C CE  . LYS A 1 54  ? 6.20413   -8.66474  -5.12864  1.000 9.40030  ? 135  LYS A CE  1 
ATOM   489  N NZ  . LYS A 1 54  ? 6.63346   -8.52953  -6.55338  1.000 8.87962  ? 135  LYS A NZ  1 
ATOM   490  N N   . ILE A 1 55  ? 9.58429   -12.94166 -0.79704  1.000 7.44766  ? 136  ILE A N   1 
ATOM   491  C CA  . ILE A 1 55  ? 10.23425  -14.18578 -0.37069  1.000 7.40983  ? 136  ILE A CA  1 
ATOM   492  C C   . ILE A 1 55  ? 9.23593   -15.26354 0.02811   1.000 6.98627  ? 136  ILE A C   1 
ATOM   493  O O   . ILE A 1 55  ? 9.40729   -16.42230 -0.38454  1.000 7.65801  ? 136  ILE A O   1 
ATOM   494  C CB  . ILE A 1 55  ? 11.32195  -13.89947 0.67339   1.000 7.44018  ? 136  ILE A CB  1 
ATOM   495  C CG1 . ILE A 1 55  ? 12.38147  -12.96003 0.09156   1.000 7.65161  ? 136  ILE A CG1 1 
ATOM   496  C CG2 . ILE A 1 55  ? 11.94182  -15.21678 1.14444   1.000 8.10012  ? 136  ILE A CG2 1 
ATOM   497  C CD1 . ILE A 1 55  ? 13.42150  -12.48787 1.10728   1.000 9.16919  ? 136  ILE A CD1 1 
ATOM   498  N N   . PRO A 1 56  ? 8.17283   -14.97439 0.78646   1.000 7.28368  ? 137  PRO A N   1 
ATOM   499  C CA  . PRO A 1 56  ? 7.17448   -16.02159 1.03513   1.000 8.45160  ? 137  PRO A CA  1 
ATOM   500  C C   . PRO A 1 56  ? 6.51775   -16.51799 -0.23824  1.000 7.17610  ? 137  PRO A C   1 
ATOM   501  O O   . PRO A 1 56  ? 6.15500   -17.70053 -0.31340  1.000 8.47778  ? 137  PRO A O   1 
ATOM   502  C CB  . PRO A 1 56  ? 6.17704   -15.34420 1.98540   1.000 8.83104  ? 137  PRO A CB  1 
ATOM   503  C CG  . PRO A 1 56  ? 6.97798   -14.30102 2.66736   1.000 9.50648  ? 137  PRO A CG  1 
ATOM   504  C CD  . PRO A 1 56  ? 7.90992   -13.78088 1.60650   1.000 7.86717  ? 137  PRO A CD  1 
ATOM   505  N N   . ASP A 1 57  ? 6.35177   -15.65715 -1.24992  1.000 7.54564  ? 138  ASP A N   1 
ATOM   506  C CA  . ASP A 1 57  ? 5.87559   -16.12932 -2.54638  1.000 8.23899  ? 138  ASP A CA  1 
ATOM   507  C C   . ASP A 1 57  ? 6.80374   -17.20230 -3.10228  1.000 7.27829  ? 138  ASP A C   1 
ATOM   508  O O   . ASP A 1 57  ? 6.33766   -18.22779 -3.61556  1.000 7.60327  ? 138  ASP A O   1 
ATOM   509  C CB  . ASP A 1 57  ? 5.79722   -14.99221 -3.57208  1.000 8.72387  ? 138  ASP A CB  1 
ATOM   510  C CG  . ASP A 1 57  ? 4.77718   -13.92307 -3.24690  1.000 9.58819  ? 138  ASP A CG  1 
ATOM   511  O OD1 . ASP A 1 57  ? 3.91874   -14.11000 -2.36321  1.000 11.10938 ? 138  ASP A OD1 1 
ATOM   512  O OD2 . ASP A 1 57  ? 4.83786   -12.87324 -3.92514  1.000 10.09890 ? 138  ASP A OD2 1 
ATOM   513  N N   . LEU A 1 58  ? 8.12525   -16.96403 -3.04808  1.000 7.45220  ? 139  LEU A N   1 
ATOM   514  C CA  . LEU A 1 58  ? 9.08219   -17.96776 -3.50656  1.000 7.39279  ? 139  LEU A CA  1 
ATOM   515  C C   . LEU A 1 58  ? 8.82048   -19.30592 -2.82858  1.000 6.96923  ? 139  LEU A C   1 
ATOM   516  O O   . LEU A 1 58  ? 8.80922   -20.35523 -3.48136  1.000 7.40974  ? 139  LEU A O   1 
ATOM   517  C CB  . LEU A 1 58  ? 10.51764  -17.50363 -3.24359  1.000 7.79421  ? 139  LEU A CB  1 
ATOM   518  C CG  . LEU A 1 58  ? 11.57932  -18.59397 -3.41666  1.000 8.59998  ? 139  LEU A CG  1 
ATOM   519  C CD1 . LEU A 1 58  ? 11.65119  -19.03892 -4.87000  1.000 10.05256 ? 139  LEU A CD1 1 
ATOM   520  C CD2 . LEU A 1 58  ? 12.92617  -18.08460 -2.92550  1.000 9.48335  ? 139  LEU A CD2 1 
ATOM   521  N N   . GLY A 1 59  ? 8.61849   -19.28360 -1.50988  1.000 7.31711  ? 140  GLY A N   1 
ATOM   522  C CA  . GLY A 1 59  ? 8.30536   -20.51418 -0.80654  1.000 7.89874  ? 140  GLY A CA  1 
ATOM   523  C C   . GLY A 1 59  ? 7.09193   -21.22217 -1.37808  1.000 7.49366  ? 140  GLY A C   1 
ATOM   524  O O   . GLY A 1 59  ? 7.10663   -22.44143 -1.55719  1.000 7.75611  ? 140  GLY A O   1 
ATOM   525  N N   . THR A 1 60  ? 6.02446   -20.47223 -1.67883  1.000 7.11666  ? 141  THR A N   1 
ATOM   526  C CA  . THR A 1 60  ? 4.84703   -21.10254 -2.28703  1.000 7.35636  ? 141  THR A CA  1 
ATOM   527  C C   . THR A 1 60  ? 5.15740   -21.68160 -3.66210  1.000 6.34893  ? 141  THR A C   1 
ATOM   528  O O   . THR A 1 60  ? 4.64725   -22.75250 -4.01292  1.000 7.63212  ? 141  THR A O   1 
ATOM   529  C CB  . THR A 1 60  ? 3.60473   -20.18843 -2.32540  1.000 7.72206  ? 141  THR A CB  1 
ATOM   530  O OG1 . THR A 1 60  ? 3.74747   -19.14023 -3.29211  1.000 8.86845  ? 141  THR A OG1 1 
ATOM   531  C CG2 . THR A 1 60  ? 3.28367   -19.60351 -0.95773  1.000 8.91648  ? 141  THR A CG2 1 
ATOM   532  N N   . TYR A 1 61  ? 5.98227   -20.99406 -4.45929  1.000 6.75915  ? 142  TYR A N   1 
ATOM   533  C CA  . TYR A 1 61  ? 6.31886   -21.51594 -5.78261  1.000 7.68237  ? 142  TYR A CA  1 
ATOM   534  C C   . TYR A 1 61  ? 7.09905   -22.81662 -5.67446  1.000 7.18939  ? 142  TYR A C   1 
ATOM   535  O O   . TYR A 1 61  ? 6.83282   -23.77473 -6.41319  1.000 7.39994  ? 142  TYR A O   1 
ATOM   536  C CB  . TYR A 1 61  ? 7.11999   -20.50675 -6.60039  1.000 7.64072  ? 142  TYR A CB  1 
ATOM   537  C CG  . TYR A 1 61  ? 6.52494   -19.13801 -6.67817  1.000 8.51063  ? 142  TYR A CG  1 
ATOM   538  C CD1 . TYR A 1 61  ? 5.16219   -18.94170 -6.61521  1.000 8.27179  ? 142  TYR A CD1 1 
ATOM   539  C CD2 . TYR A 1 61  ? 7.33862   -18.02347 -6.80573  1.000 9.02631  ? 142  TYR A CD2 1 
ATOM   540  C CE1 . TYR A 1 61  ? 4.62940   -17.66284 -6.67702  1.000 9.07869  ? 142  TYR A CE1 1 
ATOM   541  C CE2 . TYR A 1 61  ? 6.82169   -16.74474 -6.86210  1.000 9.61846  ? 142  TYR A CE2 1 
ATOM   542  C CZ  . TYR A 1 61  ? 5.46057   -16.56803 -6.79931  1.000 8.93166  ? 142  TYR A CZ  1 
ATOM   543  O OH  . TYR A 1 61  ? 4.91447   -15.30242 -6.85269  1.000 9.55976  ? 142  TYR A OH  1 
ATOM   544  N N   . LEU A 1 62  ? 8.08161   -22.85975 -4.77015  1.000 7.25527  ? 143  LEU A N   1 
ATOM   545  C CA  . LEU A 1 62  ? 8.88236   -24.06995 -4.60392  1.000 7.11241  ? 143  LEU A CA  1 
ATOM   546  C C   . LEU A 1 62  ? 8.02159   -25.23128 -4.13632  1.000 7.15871  ? 143  LEU A C   1 
ATOM   547  O O   . LEU A 1 62  ? 8.14086   -26.35383 -4.65053  1.000 7.47378  ? 143  LEU A O   1 
ATOM   548  C CB  . LEU A 1 62  ? 10.00761  -23.81921 -3.60321  1.000 7.07949  ? 143  LEU A CB  1 
ATOM   549  C CG  . LEU A 1 62  ? 11.02564  -22.76716 -4.02866  1.000 7.50496  ? 143  LEU A CG  1 
ATOM   550  C CD1 . LEU A 1 62  ? 11.88488  -22.35846 -2.83519  1.000 8.80111  ? 143  LEU A CD1 1 
ATOM   551  C CD2 . LEU A 1 62  ? 11.88546  -23.29658 -5.15581  1.000 9.98498  ? 143  LEU A CD2 1 
ATOM   552  N N   . ALA A 1 63  ? 7.13314   -24.98196 -3.17012  1.000 7.10333  ? 144  ALA A N   1 
ATOM   553  C CA  . ALA A 1 63  ? 6.30370   -26.06049 -2.65184  1.000 7.99951  ? 144  ALA A CA  1 
ATOM   554  C C   . ALA A 1 63  ? 5.29979   -26.52805 -3.69422  1.000 7.27590  ? 144  ALA A C   1 
ATOM   555  O O   . ALA A 1 63  ? 5.01878   -27.73127 -3.79535  1.000 8.80483  ? 144  ALA A O   1 
ATOM   556  C CB  . ALA A 1 63  ? 5.59664   -25.61792 -1.37741  1.000 8.80309  ? 144  ALA A CB  1 
ATOM   557  N N   . SER A 1 64  ? 4.73263   -25.59343 -4.46234  1.000 7.82148  ? 145  SER A N   1 
ATOM   558  C CA  . SER A 1 64  ? 3.80694   -25.97770 -5.52117  1.000 8.06842  ? 145  SER A CA  1 
ATOM   559  C C   . SER A 1 64  ? 4.52753   -26.73200 -6.62394  1.000 8.09350  ? 145  SER A C   1 
ATOM   560  O O   . SER A 1 64  ? 4.00202   -27.71937 -7.15455  1.000 8.62162  ? 145  SER A O   1 
ATOM   561  C CB  . SER A 1 64  ? 3.13008   -24.73838 -6.09706  1.000 8.35141  ? 145  SER A CB  1 
ATOM   562  O OG  . SER A 1 64  ? 2.31939   -24.11445 -5.12826  1.000 8.56223  ? 145  SER A OG  1 
ATOM   563  N N   . ALA A 1 65  ? 5.72309   -26.27429 -6.99592  1.000 7.42203  ? 146  ALA A N   1 
ATOM   564  C CA  . ALA A 1 65  ? 6.49921   -26.97820 -8.00660  1.000 8.02302  ? 146  ALA A CA  1 
ATOM   565  C C   . ALA A 1 65  ? 6.86558   -28.38263 -7.53911  1.000 7.60934  ? 146  ALA A C   1 
ATOM   566  O O   . ALA A 1 65  ? 6.76701   -29.34586 -8.30898  1.000 8.50213  ? 146  ALA A O   1 
ATOM   567  C CB  . ALA A 1 65  ? 7.75052   -26.16954 -8.33938  1.000 7.76792  ? 146  ALA A CB  1 
ATOM   568  N N   . SER A 1 66  ? 7.27603   -28.52627 -6.27833  1.000 7.72728  ? 147  SER A N   1 
ATOM   569  C CA  . SER A 1 66  ? 7.61646   -29.85068 -5.77265  1.000 8.73109  ? 147  SER A CA  1 
ATOM   570  C C   . SER A 1 66  ? 6.42651   -30.78938 -5.88748  1.000 9.07220  ? 147  SER A C   1 
ATOM   571  O O   . SER A 1 66  ? 6.56090   -31.92743 -6.35741  1.000 9.61481  ? 147  SER A O   1 
ATOM   572  C CB  . SER A 1 66  ? 8.07984   -29.73399 -4.32241  1.000 9.08684  ? 147  SER A CB  1 
ATOM   573  O OG  . SER A 1 66  ? 8.41554   -30.99772 -3.77810  1.000 10.98703 ? 147  SER A OG  1 
ATOM   574  N N   A ALA A 1 67  ? 5.25941   -30.33837 -5.43005  0.769 8.79602  ? 148  ALA A N   1 
ATOM   575  N N   B ALA A 1 67  ? 5.23629   -30.30232 -5.52514  0.231 8.96067  ? 148  ALA A N   1 
ATOM   576  C CA  A ALA A 1 67  ? 4.07058   -31.17708 -5.49508  0.769 10.06390 ? 148  ALA A CA  1 
ATOM   577  C CA  B ALA A 1 67  ? 4.03337   -31.12836 -5.56781  0.231 10.13611 ? 148  ALA A CA  1 
ATOM   578  C C   A ALA A 1 67  ? 3.70752   -31.50703 -6.93581  0.769 9.58198  ? 148  ALA A C   1 
ATOM   579  C C   B ALA A 1 67  ? 3.62230   -31.45193 -7.00076  0.231 9.94953  ? 148  ALA A C   1 
ATOM   580  O O   A ALA A 1 67  ? 3.29722   -32.63672 -7.23607  0.769 10.45499 ? 148  ALA A O   1 
ATOM   581  O O   B ALA A 1 67  ? 3.33623   -32.61166 -7.32424  0.231 10.75305 ? 148  ALA A O   1 
ATOM   582  C CB  A ALA A 1 67  ? 2.90694   -30.48000 -4.79177  0.769 11.50310 ? 148  ALA A CB  1 
ATOM   583  C CB  B ALA A 1 67  ? 2.89609   -30.42908 -4.82379  0.231 11.49126 ? 148  ALA A CB  1 
ATOM   584  N N   A LEU A 1 68  ? 3.84100   -30.53203 -7.84196  0.769 9.26790  ? 149  LEU A N   1 
ATOM   585  N N   B LEU A 1 68  ? 3.57198   -30.43812 -7.87408  0.231 10.37576 ? 149  LEU A N   1 
ATOM   586  C CA  A LEU A 1 68  ? 3.49212   -30.77743 -9.23744  0.769 9.81301  ? 149  LEU A CA  1 
ATOM   587  C CA  B LEU A 1 68  ? 3.15377   -30.67271 -9.25415  0.231 9.48421  ? 149  LEU A CA  1 
ATOM   588  C C   A LEU A 1 68  ? 4.42348   -31.81134 -9.85140  0.769 9.72423  ? 149  LEU A C   1 
ATOM   589  C C   B LEU A 1 68  ? 4.10784   -31.60562 -9.98988  0.231 8.94297  ? 149  LEU A C   1 
ATOM   590  O O   A LEU A 1 68  ? 3.97702   -32.70278 -10.58381 0.769 10.67025 ? 149  LEU A O   1 
ATOM   591  O O   B LEU A 1 68  ? 3.70584   -32.24798 -10.96702 0.231 7.54200  ? 149  LEU A O   1 
ATOM   592  C CB  A LEU A 1 68  ? 3.52168   -29.46817 -10.03132 0.769 9.57683  ? 149  LEU A CB  1 
ATOM   593  C CB  B LEU A 1 68  ? 2.96915   -29.34419 -10.00009 0.231 12.50830 ? 149  LEU A CB  1 
ATOM   594  C CG  A LEU A 1 68  ? 2.97560   -29.46723 -11.46494 0.769 12.27290 ? 149  LEU A CG  1 
ATOM   595  C CG  B LEU A 1 68  ? 2.71639   -29.40133 -11.51077 0.231 12.47718 ? 149  LEU A CG  1 
ATOM   596  C CD1 A LEU A 1 68  ? 1.50105   -29.85475 -11.48556 0.769 11.99888 ? 149  LEU A CD1 1 
ATOM   597  C CD1 B LEU A 1 68  ? 1.24912   -29.14600 -11.82278 0.231 13.72094 ? 149  LEU A CD1 1 
ATOM   598  C CD2 A LEU A 1 68  ? 3.17260   -28.10891 -12.13107 0.769 13.03411 ? 149  LEU A CD2 1 
ATOM   599  C CD2 B LEU A 1 68  ? 3.60028   -28.41646 -12.25240 0.231 11.89810 ? 149  LEU A CD2 1 
ATOM   600  N N   A GLY A 1 69  ? 5.72070   -31.71555 -9.55577  0.769 9.47898  ? 150  GLY A N   1 
ATOM   601  N N   B GLY A 1 69  ? 5.35083   -31.71219 -9.52836  0.231 10.18153 ? 150  GLY A N   1 
ATOM   602  C CA  A GLY A 1 69  ? 6.64969   -32.71871 -10.04113 0.769 10.42709 ? 150  GLY A CA  1 
ATOM   603  C CA  B GLY A 1 69  ? 6.28677   -32.67496 -10.06988 0.231 9.94856  ? 150  GLY A CA  1 
ATOM   604  C C   A GLY A 1 69  ? 6.26633   -34.11378 -9.59146  0.769 10.67359 ? 150  GLY A C   1 
ATOM   605  C C   B GLY A 1 69  ? 6.08518   -34.07833 -9.53243  0.231 10.49669 ? 150  GLY A C   1 
ATOM   606  O O   A GLY A 1 69  ? 6.32092   -35.07031 -10.37112 0.769 12.90712 ? 150  GLY A O   1 
ATOM   607  O O   B GLY A 1 69  ? 5.92142   -35.02217 -10.31305 0.231 10.59309 ? 150  GLY A O   1 
ATOM   608  N N   A LYS A 1 70  ? 5.83689   -34.24307 -8.33702  0.769 11.42407 ? 151  LYS A N   1 
ATOM   609  N N   B LYS A 1 70  ? 6.09468   -34.22553 -8.20074  0.231 8.53323  ? 151  LYS A N   1 
ATOM   610  C CA  A LYS A 1 70  ? 5.45091   -35.55195 -7.82674  0.769 12.94829 ? 151  LYS A CA  1 
ATOM   611  C CA  B LYS A 1 70  ? 5.94711   -35.54242 -7.58530  0.231 11.01990 ? 151  LYS A CA  1 
ATOM   612  C C   A LYS A 1 70  ? 4.22760   -36.09892 -8.55116  0.769 13.36349 ? 151  LYS A C   1 
ATOM   613  C C   B LYS A 1 70  ? 4.64201   -36.21790 -7.98784  0.231 10.64104 ? 151  LYS A C   1 
ATOM   614  O O   A LYS A 1 70  ? 4.15202   -37.30117 -8.82963  0.769 17.06361 ? 151  LYS A O   1 
ATOM   615  O O   B LYS A 1 70  ? 4.59078   -37.44811 -8.10261  0.231 10.06277 ? 151  LYS A O   1 
ATOM   616  C CB  A LYS A 1 70  ? 5.19668   -35.46891 -6.32405  0.769 14.47223 ? 151  LYS A CB  1 
ATOM   617  C CB  B LYS A 1 70  ? 6.03906   -35.42566 -6.06135  0.231 9.78911  ? 151  LYS A CB  1 
ATOM   618  C CG  A LYS A 1 70  ? 6.45314   -35.29188 -5.50918  0.769 19.29732 ? 151  LYS A CG  1 
ATOM   619  C CG  B LYS A 1 70  ? 7.43521   -35.69040 -5.50519  0.231 15.22298 ? 151  LYS A CG  1 
ATOM   620  C CD  A LYS A 1 70  ? 6.12586   -35.14077 -4.04064  0.769 19.69862 ? 151  LYS A CD  1 
ATOM   621  C CD  B LYS A 1 70  ? 7.75270   -34.84580 -4.27021  0.231 17.58219 ? 151  LYS A CD  1 
ATOM   622  C CE  A LYS A 1 70  ? 7.12560   -34.22764 -3.35424  0.769 19.63079 ? 151  LYS A CE  1 
ATOM   623  C CE  B LYS A 1 70  ? 6.56591   -34.01261 -3.80901  0.231 16.51214 ? 151  LYS A CE  1 
ATOM   624  N NZ  A LYS A 1 70  ? 6.71719   -33.92040 -1.95380  0.769 22.07880 ? 151  LYS A NZ  1 
ATOM   625  N NZ  B LYS A 1 70  ? 6.00602   -34.50466 -2.51807  0.231 18.36200 ? 151  LYS A NZ  1 
ATOM   626  N N   A SER A 1 71  ? 3.26686   -35.23933 -8.87672  0.769 13.07997 ? 152  SER A N   1 
ATOM   627  N N   B SER A 1 71  ? 3.58234   -35.43888 -8.21201  0.231 5.52413  ? 152  SER A N   1 
ATOM   628  C CA  A SER A 1 71  ? 1.99308   -35.70095 -9.41545  0.769 16.03247 ? 152  SER A CA  1 
ATOM   629  C CA  B SER A 1 71  ? 2.31135   -36.02367 -8.62176  0.231 10.29202 ? 152  SER A CA  1 
ATOM   630  C C   A SER A 1 71  ? 1.94126   -35.73339 -10.93910 0.769 12.85141 ? 152  SER A C   1 
ATOM   631  C C   B SER A 1 71  ? 2.32132   -36.44272 -10.08553 0.231 12.45277 ? 152  SER A C   1 
ATOM   632  O O   A SER A 1 71  ? 0.98420   -36.28427 -11.49490 0.769 15.29131 ? 152  SER A O   1 
ATOM   633  O O   B SER A 1 71  ? 1.58684   -37.35971 -10.46733 0.231 9.78130  ? 152  SER A O   1 
ATOM   634  C CB  A SER A 1 71  ? 0.84396   -34.84641 -8.87683  0.769 20.04925 ? 152  SER A CB  1 
ATOM   635  C CB  B SER A 1 71  ? 1.16617   -35.04274 -8.36508  0.231 10.57388 ? 152  SER A CB  1 
ATOM   636  O OG  A SER A 1 71  ? 1.19010   -33.47430 -8.89317  0.769 18.23447 ? 152  SER A OG  1 
ATOM   637  O OG  B SER A 1 71  ? 1.15232   -34.00457 -9.33049  0.231 14.76537 ? 152  SER A OG  1 
ATOM   638  N N   A THR A 1 72  ? 2.92940   -35.16327 -11.62810 0.769 12.37967 ? 153  THR A N   1 
ATOM   639  N N   B THR A 1 72  ? 3.13885   -35.79506 -10.91244 0.231 7.11795  ? 153  THR A N   1 
ATOM   640  C CA  A THR A 1 72  ? 3.01365   -35.25869 -13.07876 0.769 12.69292 ? 153  THR A CA  1 
ATOM   641  C CA  B THR A 1 72  ? 3.18998   -36.07721 -12.33954 0.231 8.28279  ? 153  THR A CA  1 
ATOM   642  C C   A THR A 1 72  ? 4.18035   -36.11437 -13.54933 0.769 11.99770 ? 153  THR A C   1 
ATOM   643  C C   B THR A 1 72  ? 4.47721   -36.76675 -12.76510 0.231 11.12571 ? 153  THR A C   1 
ATOM   644  O O   A THR A 1 72  ? 4.37534   -36.25876 -14.76265 0.769 14.24797 ? 153  THR A O   1 
ATOM   645  O O   B THR A 1 72  ? 4.61229   -37.12738 -13.93978 0.231 8.13076  ? 153  THR A O   1 
ATOM   646  C CB  A THR A 1 72  ? 3.08200   -33.86933 -13.72504 0.769 13.22002 ? 153  THR A CB  1 
ATOM   647  C CB  B THR A 1 72  ? 3.00773   -34.78165 -13.13800 0.231 9.38088  ? 153  THR A CB  1 
ATOM   648  O OG1 A THR A 1 72  ? 4.31641   -33.22924 -13.37405 0.769 13.61943 ? 153  THR A OG1 1 
ATOM   649  O OG1 B THR A 1 72  ? 4.10863   -33.90329 -12.86915 0.231 8.02983  ? 153  THR A OG1 1 
ATOM   650  C CG2 A THR A 1 72  ? 1.91609   -33.01098 -13.26393 0.769 14.22685 ? 153  THR A CG2 1 
ATOM   651  C CG2 B THR A 1 72  ? 1.70222   -34.09687 -12.75656 0.231 11.11824 ? 153  THR A CG2 1 
ATOM   652  N N   A GLY A 1 73  ? 4.94911   -36.69175 -12.62697 0.769 15.62089 ? 154  GLY A N   1 
ATOM   653  N N   B GLY A 1 73  ? 5.42016   -36.96429 -11.84678 0.231 9.79616  ? 154  GLY A N   1 
ATOM   654  C CA  A GLY A 1 73  ? 6.07395   -37.52962 -12.98906 0.769 18.28589 ? 154  GLY A CA  1 
ATOM   655  C CA  B GLY A 1 73  ? 6.70645   -37.52957 -12.20344 0.231 15.54105 ? 154  GLY A CA  1 
ATOM   656  C C   A GLY A 1 73  ? 7.29150   -36.78197 -13.46785 0.769 15.22486 ? 154  GLY A C   1 
ATOM   657  C C   B GLY A 1 73  ? 7.57990   -36.63493 -13.05358 0.231 15.07067 ? 154  GLY A C   1 
ATOM   658  O O   A GLY A 1 73  ? 8.15300   -37.37368 -14.12563 0.769 17.27779 ? 154  GLY A O   1 
ATOM   659  O O   B GLY A 1 73  ? 8.54663   -37.11677 -13.64945 0.231 16.47998 ? 154  GLY A O   1 
ATOM   660  N N   A THR A 1 74  ? 7.40459   -35.50338 -13.13563 0.769 15.76315 ? 155  THR A N   1 
ATOM   661  N N   B THR A 1 74  ? 7.26702   -35.34161 -13.13050 0.231 15.71557 ? 155  THR A N   1 
ATOM   662  C CA  A THR A 1 74  ? 8.40506   -34.62648 -13.71310 0.769 13.50519 ? 155  THR A CA  1 
ATOM   663  C CA  B THR A 1 74  ? 7.99485   -34.38221 -13.96170 0.231 13.44374 ? 155  THR A CA  1 
ATOM   664  C C   A THR A 1 74  ? 9.26961   -34.01217 -12.62624 0.769 9.19606  ? 155  THR A C   1 
ATOM   665  C C   B THR A 1 74  ? 8.51306   -33.27268 -13.05508 0.231 12.60315 ? 155  THR A C   1 
ATOM   666  O O   A THR A 1 74  ? 8.94962   -34.03491 -11.43560 0.769 11.40438 ? 155  THR A O   1 
ATOM   667  O O   B THR A 1 74  ? 7.78514   -32.32181 -12.75673 0.231 14.40638 ? 155  THR A O   1 
ATOM   668  C CB  A THR A 1 74  ? 7.72966   -33.49725 -14.49850 0.769 10.90603 ? 155  THR A CB  1 
ATOM   669  C CB  B THR A 1 74  ? 7.08224   -33.81651 -15.04450 0.231 17.42225 ? 155  THR A CB  1 
ATOM   670  O OG1 A THR A 1 74  ? 6.83719   -32.78216 -13.63109 0.769 11.97936 ? 155  THR A OG1 1 
ATOM   671  O OG1 B THR A 1 74  ? 6.13493   -32.91622 -14.45349 0.231 18.26342 ? 155  THR A OG1 1 
ATOM   672  C CG2 A THR A 1 74  ? 6.94979   -34.05803 -15.67219 0.769 16.29405 ? 155  THR A CG2 1 
ATOM   673  C CG2 B THR A 1 74  ? 6.33877   -34.93785 -15.73306 0.231 17.47009 ? 155  THR A CG2 1 
ATOM   674  N N   A LYS A 1 75  ? 10.37658  -33.43709 -13.06542 0.769 7.27068  ? 156  LYS A N   1 
ATOM   675  N N   B LYS A 1 75  ? 9.77012   -33.38741 -12.63173 0.231 14.07328 ? 156  LYS A N   1 
ATOM   676  C CA  A LYS A 1 75  ? 11.17766  -32.56581 -12.22983 0.769 7.77983  ? 156  LYS A CA  1 
ATOM   677  C CA  B LYS A 1 75  ? 10.33548  -32.41518 -11.70859 0.231 14.11141 ? 156  LYS A CA  1 
ATOM   678  C C   A LYS A 1 75  ? 10.89986  -31.13748 -12.66762 0.769 6.99977  ? 156  LYS A C   1 
ATOM   679  C C   B LYS A 1 75  ? 10.25032  -31.01659 -12.30247 0.231 11.94093 ? 156  LYS A C   1 
ATOM   680  O O   A LYS A 1 75  ? 10.86626  -30.84418 -13.86863 0.769 9.14200  ? 156  LYS A O   1 
ATOM   681  O O   B LYS A 1 75  ? 10.29167  -30.82715 -13.52232 0.231 13.63236 ? 156  LYS A O   1 
ATOM   682  C CB  A LYS A 1 75  ? 12.65771  -32.90601 -12.38019 0.769 9.97108  ? 156  LYS A CB  1 
ATOM   683  C CB  B LYS A 1 75  ? 11.79971  -32.73063 -11.44219 0.231 13.66791 ? 156  LYS A CB  1 
ATOM   684  C CG  A LYS A 1 75  ? 12.98928  -34.30495 -11.89690 0.769 11.16919 ? 156  LYS A CG  1 
ATOM   685  C CG  B LYS A 1 75  ? 12.57667  -32.96581 -12.70574 0.231 10.67586 ? 156  LYS A CG  1 
ATOM   686  C CD  A LYS A 1 75  ? 14.45098  -34.61927 -12.12244 0.769 15.00549 ? 156  LYS A CD  1 
ATOM   687  C CD  B LYS A 1 75  ? 13.74590  -33.87857 -12.47520 0.231 14.85195 ? 156  LYS A CD  1 
ATOM   688  C CE  A LYS A 1 75  ? 14.80026  -36.02356 -11.66542 0.769 17.32475 ? 156  LYS A CE  1 
ATOM   689  C CE  B LYS A 1 75  ? 14.63615  -33.86255 -13.68922 0.231 13.86767 ? 156  LYS A CE  1 
ATOM   690  N NZ  A LYS A 1 75  ? 16.27349  -36.24112 -11.65776 0.769 23.43224 ? 156  LYS A NZ  1 
ATOM   691  N NZ  B LYS A 1 75  ? 14.01060  -33.11796 -14.82114 0.231 16.34363 ? 156  LYS A NZ  1 
ATOM   692  N N   A GLN A 1 76  ? 10.67479  -30.26382 -11.69949 0.769 5.88539  ? 157  GLN A N   1 
ATOM   693  N N   B GLN A 1 76  ? 10.14427  -30.03050 -11.42227 0.231 11.87047 ? 157  GLN A N   1 
ATOM   694  C CA  A GLN A 1 76  ? 10.21876  -28.91419 -11.96367 0.769 6.15517  ? 157  GLN A CA  1 
ATOM   695  C CA  B GLN A 1 76  ? 9.89504   -28.65856 -11.82183 0.231 11.11821 ? 157  GLN A CA  1 
ATOM   696  C C   A GLN A 1 76  ? 11.33466  -27.90208 -11.74295 0.769 6.56634  ? 157  GLN A C   1 
ATOM   697  C C   B GLN A 1 76  ? 11.12707  -27.78629 -11.61412 0.231 9.54234  ? 157  GLN A C   1 
ATOM   698  O O   A GLN A 1 76  ? 12.23094  -28.10132 -10.91339 0.769 7.06888  ? 157  GLN A O   1 
ATOM   699  O O   B GLN A 1 76  ? 11.93659  -28.00268 -10.70730 0.231 8.25480  ? 157  GLN A O   1 
ATOM   700  C CB  A GLN A 1 76  ? 9.02638   -28.57824 -11.07022 0.769 6.55023  ? 157  GLN A CB  1 
ATOM   701  C CB  B GLN A 1 76  ? 8.70950   -28.06996 -11.05291 0.231 11.15204 ? 157  GLN A CB  1 
ATOM   702  C CG  A GLN A 1 76  ? 7.81614   -29.46816 -11.31631 0.769 7.54417  ? 157  GLN A CG  1 
ATOM   703  C CG  B GLN A 1 76  ? 7.36302   -28.75891 -11.29862 0.231 11.90277 ? 157  GLN A CG  1 
ATOM   704  C CD  A GLN A 1 76  ? 6.96842   -29.01651 -12.49470 0.769 9.25305  ? 157  GLN A CD  1 
ATOM   705  C CD  B GLN A 1 76  ? 6.99574   -28.86253 -12.76747 0.231 11.70680 ? 157  GLN A CD  1 
ATOM   706  O OE1 A GLN A 1 76  ? 6.70418   -27.82160 -12.67127 0.769 10.03900 ? 157  GLN A OE1 1 
ATOM   707  O OE1 B GLN A 1 76  ? 7.05441   -27.87882 -13.50169 0.231 12.83856 ? 157  GLN A OE1 1 
ATOM   708  N NE2 A GLN A 1 76  ? 6.51234   -29.97417 -13.29771 0.769 10.84427 ? 157  GLN A NE2 1 
ATOM   709  N NE2 B GLN A 1 76  ? 6.59324   -30.05343 -13.19773 0.231 11.23925 ? 157  GLN A NE2 1 
ATOM   710  N N   . LEU A 1 77  ? 11.23745  -26.79274 -12.48350 1.000 7.17951  ? 158  LEU A N   1 
ATOM   711  C CA  . LEU A 1 77  ? 12.24893  -25.75004 -12.45737 1.000 7.08157  ? 158  LEU A CA  1 
ATOM   712  C C   . LEU A 1 77  ? 11.55719  -24.40863 -12.23591 1.000 6.68583  ? 158  LEU A C   1 
ATOM   713  O O   . LEU A 1 77  ? 10.63978  -24.03870 -12.97968 1.000 7.55147  ? 158  LEU A O   1 
ATOM   714  C CB  . LEU A 1 77  ? 13.01381  -25.76854 -13.78535 1.000 8.16913  ? 158  LEU A CB  1 
ATOM   715  C CG  . LEU A 1 77  ? 14.21253  -24.84165 -13.95915 1.000 6.85344  ? 158  LEU A CG  1 
ATOM   716  C CD1 . LEU A 1 77  ? 15.13600  -25.39962 -15.02956 1.000 8.03082  ? 158  LEU A CD1 1 
ATOM   717  C CD2 . LEU A 1 77  ? 13.80343  -23.40622 -14.29614 1.000 7.81352  ? 158  LEU A CD2 1 
ATOM   718  N N   . VAL A 1 78  ? 12.01822  -23.67584 -11.23000 1.000 6.62765  ? 159  VAL A N   1 
ATOM   719  C CA  . VAL A 1 78  ? 11.46822  -22.37709 -10.85722 1.000 6.63427  ? 159  VAL A CA  1 
ATOM   720  C C   . VAL A 1 78  ? 12.44992  -21.28367 -11.27182 1.000 6.35999  ? 159  VAL A C   1 
ATOM   721  O O   . VAL A 1 78  ? 13.64514  -21.35489 -10.95659 1.000 6.98859  ? 159  VAL A O   1 
ATOM   722  C CB  . VAL A 1 78  ? 11.17113  -22.33573 -9.34831  1.000 6.81809  ? 159  VAL A CB  1 
ATOM   723  C CG1 . VAL A 1 78  ? 10.85468  -20.91924 -8.87499  1.000 9.40033  ? 159  VAL A CG1 1 
ATOM   724  C CG2 . VAL A 1 78  ? 10.03969  -23.30274 -9.00381  1.000 7.95499  ? 159  VAL A CG2 1 
ATOM   725  N N   . GLN A 1 79  ? 11.94223  -20.27256 -11.97574 1.000 6.16706  ? 160  GLN A N   1 
ATOM   726  C CA  . GLN A 1 79  ? 12.74671  -19.19440 -12.55688 1.000 6.60678  ? 160  GLN A CA  1 
ATOM   727  C C   . GLN A 1 79  ? 12.54743  -17.91368 -11.75519 1.000 6.24405  ? 160  GLN A C   1 
ATOM   728  O O   . GLN A 1 79  ? 11.42247  -17.40752 -11.67291 1.000 6.62271  ? 160  GLN A O   1 
ATOM   729  C CB  . GLN A 1 79  ? 12.33631  -18.95846 -14.01229 1.000 6.89175  ? 160  GLN A CB  1 
ATOM   730  C CG  . GLN A 1 79  ? 12.50718  -20.18468 -14.90416 1.000 7.15235  ? 160  GLN A CG  1 
ATOM   731  C CD  . GLN A 1 79  ? 12.29154  -19.90816 -16.37830 1.000 6.53206  ? 160  GLN A CD  1 
ATOM   732  O OE1 . GLN A 1 79  ? 12.94549  -20.52119 -17.22716 1.000 7.66977  ? 160  GLN A OE1 1 
ATOM   733  N NE2 . GLN A 1 79  ? 11.37723  -19.00069 -16.69808 1.000 7.44337  ? 160  GLN A NE2 1 
ATOM   734  N N   . ILE A 1 80  ? 13.62751  -17.37924 -11.17817 1.000 6.54980  ? 161  ILE A N   1 
ATOM   735  C CA  . ILE A 1 80  ? 13.53724  -16.20154 -10.32804 1.000 6.76889  ? 161  ILE A CA  1 
ATOM   736  C C   . ILE A 1 80  ? 14.57616  -15.15246 -10.72288 1.000 6.43216  ? 161  ILE A C   1 
ATOM   737  O O   . ILE A 1 80  ? 15.61006  -15.45355 -11.32338 1.000 6.61050  ? 161  ILE A O   1 
ATOM   738  C CB  . ILE A 1 80  ? 13.66170  -16.52386 -8.81887  1.000 6.97959  ? 161  ILE A CB  1 
ATOM   739  C CG1 . ILE A 1 80  ? 15.06396  -17.06512 -8.48315  1.000 7.92536  ? 161  ILE A CG1 1 
ATOM   740  C CG2 . ILE A 1 80  ? 12.55648  -17.48435 -8.38071  1.000 10.40413 ? 161  ILE A CG2 1 
ATOM   741  C CD1 . ILE A 1 80  ? 15.24685  -17.45910 -7.02670  1.000 9.22173  ? 161  ILE A CD1 1 
ATOM   742  N N   . VAL A 1 81  ? 14.29361  -13.90535 -10.34021 1.000 5.95532  ? 162  VAL A N   1 
ATOM   743  C CA  . VAL A 1 81  ? 15.23208  -12.79187 -10.43731 1.000 6.01466  ? 162  VAL A CA  1 
ATOM   744  C C   . VAL A 1 81  ? 15.54509  -12.29870 -9.03351  1.000 5.95577  ? 162  VAL A C   1 
ATOM   745  O O   . VAL A 1 81  ? 14.63723  -11.98117 -8.25601  1.000 6.67254  ? 162  VAL A O   1 
ATOM   746  C CB  . VAL A 1 81  ? 14.71730  -11.63317 -11.30989 1.000 6.16318  ? 162  VAL A CB  1 
ATOM   747  C CG1 . VAL A 1 81  ? 15.85604  -10.64134 -11.58879 1.000 7.15739  ? 162  VAL A CG1 1 
ATOM   748  C CG2 . VAL A 1 81  ? 14.12450  -12.15405 -12.60043 1.000 6.98173  ? 162  VAL A CG2 1 
ATOM   749  N N   . ILE A 1 82  ? 16.83234  -12.22054 -8.71832  1.000 5.90417  ? 163  ILE A N   1 
ATOM   750  C CA  . ILE A 1 82  ? 17.31675  -11.61605 -7.48518  1.000 6.25806  ? 163  ILE A CA  1 
ATOM   751  C C   . ILE A 1 82  ? 17.50115  -10.12938 -7.79057  1.000 6.10750  ? 163  ILE A C   1 
ATOM   752  O O   . ILE A 1 82  ? 18.32861  -9.75977  -8.63100  1.000 6.53884  ? 163  ILE A O   1 
ATOM   753  C CB  . ILE A 1 82  ? 18.63789  -12.27128 -7.05737  1.000 6.58767  ? 163  ILE A CB  1 
ATOM   754  C CG1 . ILE A 1 82  ? 18.49620  -13.80037 -6.94944  1.000 7.80808  ? 163  ILE A CG1 1 
ATOM   755  C CG2 . ILE A 1 82  ? 19.17507  -11.63522 -5.78126  1.000 8.38647  ? 163  ILE A CG2 1 
ATOM   756  C CD1 . ILE A 1 82  ? 17.48553  -14.27567 -5.93375  1.000 10.10981 ? 163  ILE A CD1 1 
ATOM   757  N N   . TYR A 1 83  ? 16.69916  -9.26648  -7.14904  1.000 6.81242  ? 164  TYR A N   1 
ATOM   758  C CA  . TYR A 1 83  ? 16.66113  -7.85619  -7.55746  1.000 6.78510  ? 164  TYR A CA  1 
ATOM   759  C C   . TYR A 1 83  ? 16.30106  -6.97846  -6.35892  1.000 6.50708  ? 164  TYR A C   1 
ATOM   760  O O   . TYR A 1 83  ? 15.19931  -6.42335  -6.26289  1.000 6.83445  ? 164  TYR A O   1 
ATOM   761  C CB  . TYR A 1 83  ? 15.68231  -7.62913  -8.71163  1.000 7.06548  ? 164  TYR A CB  1 
ATOM   762  C CG  . TYR A 1 83  ? 15.71788  -6.23891  -9.30460  1.000 7.36644  ? 164  TYR A CG  1 
ATOM   763  C CD1 . TYR A 1 83  ? 16.88850  -5.73496  -9.86124  1.000 7.74571  ? 164  TYR A CD1 1 
ATOM   764  C CD2 . TYR A 1 83  ? 14.58370  -5.42893  -9.31045  1.000 7.47277  ? 164  TYR A CD2 1 
ATOM   765  C CE1 . TYR A 1 83  ? 16.92712  -4.47371  -10.41938 1.000 8.24154  ? 164  TYR A CE1 1 
ATOM   766  C CE2 . TYR A 1 83  ? 14.61764  -4.15837  -9.86836  1.000 7.28047  ? 164  TYR A CE2 1 
ATOM   767  C CZ  . TYR A 1 83  ? 15.79825  -3.68542  -10.41228 1.000 8.24584  ? 164  TYR A CZ  1 
ATOM   768  O OH  . TYR A 1 83  ? 15.83452  -2.41972  -10.96065 1.000 9.34346  ? 164  TYR A OH  1 
ATOM   769  N N   . ASP A 1 84  ? 17.24138  -6.84218  -5.41625  1.000 6.78768  ? 165  ASP A N   1 
ATOM   770  C CA  . ASP A 1 84  ? 16.96348  -6.02287  -4.24506  1.000 6.84658  ? 165  ASP A CA  1 
ATOM   771  C C   . ASP A 1 84  ? 18.21576  -5.37182  -3.67092  1.000 6.57846  ? 165  ASP A C   1 
ATOM   772  O O   . ASP A 1 84  ? 18.27916  -5.13907  -2.45990  1.000 6.92126  ? 165  ASP A O   1 
ATOM   773  C CB  . ASP A 1 84  ? 16.19766  -6.81852  -3.17570  1.000 7.22791  ? 165  ASP A CB  1 
ATOM   774  C CG  . ASP A 1 84  ? 15.32475  -5.95016  -2.27946  1.000 6.87001  ? 165  ASP A CG  1 
ATOM   775  O OD1 . ASP A 1 84  ? 15.10575  -4.74780  -2.55325  1.000 8.21460  ? 165  ASP A OD1 1 
ATOM   776  O OD2 . ASP A 1 84  ? 14.81647  -6.53243  -1.28193  1.000 7.72886  ? 165  ASP A OD2 1 
ATOM   777  N N   . LEU A 1 85  ? 19.19380  -5.03541  -4.50992  1.000 6.67128  ? 166  LEU A N   1 
ATOM   778  C CA  . LEU A 1 85  ? 20.42187  -4.45359  -3.99015  1.000 7.00423  ? 166  LEU A CA  1 
ATOM   779  C C   . LEU A 1 85  ? 20.13304  -3.16643  -3.22713  1.000 7.62099  ? 166  LEU A C   1 
ATOM   780  O O   . LEU A 1 85  ? 19.22128  -2.41289  -3.58018  1.000 7.84215  ? 166  LEU A O   1 
ATOM   781  C CB  . LEU A 1 85  ? 21.37068  -4.11465  -5.13156  1.000 7.75717  ? 166  LEU A CB  1 
ATOM   782  C CG  . LEU A 1 85  ? 22.18823  -5.29272  -5.64496  1.000 7.42904  ? 166  LEU A CG  1 
ATOM   783  C CD1 . LEU A 1 85  ? 22.93415  -4.86673  -6.86830  1.000 8.06328  ? 166  LEU A CD1 1 
ATOM   784  C CD2 . LEU A 1 85  ? 23.14969  -5.79976  -4.60645  1.000 9.37349  ? 166  LEU A CD2 1 
ATOM   785  N N   . PRO A 1 86  ? 20.92400  -2.86853  -2.20103  1.000 7.35166  ? 167  PRO A N   1 
ATOM   786  C CA  . PRO A 1 86  ? 20.89111  -1.51762  -1.62900  1.000 7.76683  ? 167  PRO A CA  1 
ATOM   787  C C   . PRO A 1 86  ? 21.29162  -0.50725  -2.69209  1.000 8.01839  ? 167  PRO A C   1 
ATOM   788  O O   . PRO A 1 86  ? 22.16556  -0.76774  -3.51915  1.000 7.84869  ? 167  PRO A O   1 
ATOM   789  C CB  . PRO A 1 86  ? 21.92943  -1.58050  -0.49879  1.000 9.68912  ? 167  PRO A CB  1 
ATOM   790  C CG  . PRO A 1 86  ? 22.24649  -3.03573  -0.30949  1.000 10.02064 ? 167  PRO A CG  1 
ATOM   791  C CD  . PRO A 1 86  ? 22.00597  -3.68785  -1.62808  1.000 8.75198  ? 167  PRO A CD  1 
ATOM   792  N N   . ASP A 1 87  ? 20.62805  0.64881   -2.68417  1.000 7.70909  ? 168  ASP A N   1 
ATOM   793  C CA  . ASP A 1 87  ? 20.88030  1.68404   -3.68771  1.000 8.18338  ? 168  ASP A CA  1 
ATOM   794  C C   . ASP A 1 87  ? 20.69993  1.10665   -5.09203  1.000 8.76021  ? 168  ASP A C   1 
ATOM   795  O O   . ASP A 1 87  ? 21.51096  1.33811   -5.99435  1.000 8.16683  ? 168  ASP A O   1 
ATOM   796  C CB  . ASP A 1 87  ? 22.26857  2.30247   -3.50537  1.000 9.04555  ? 168  ASP A CB  1 
ATOM   797  C CG  . ASP A 1 87  ? 22.32800  3.28942   -2.34603  1.000 8.91759  ? 168  ASP A CG  1 
ATOM   798  O OD1 . ASP A 1 87  ? 21.56353  3.14947   -1.36241  1.000 11.57161 ? 168  ASP A OD1 1 
ATOM   799  O OD2 . ASP A 1 87  ? 23.21257  4.17196   -2.37387  1.000 12.46797 ? 168  ASP A OD2 1 
ATOM   800  N N   . ARG A 1 88  ? 19.62384  0.34089   -5.26237  1.000 7.76107  ? 169  ARG A N   1 
ATOM   801  C CA  . ARG A 1 88  ? 19.31569  -0.31782  -6.51900  1.000 7.83716  ? 169  ARG A CA  1 
ATOM   802  C C   . ARG A 1 88  ? 19.15511  0.71284   -7.62959  1.000 8.23780  ? 169  ARG A C   1 
ATOM   803  O O   . ARG A 1 88  ? 18.70537  1.83703   -7.39771  1.000 9.90119  ? 169  ARG A O   1 
ATOM   804  C CB  . ARG A 1 88  ? 17.99709  -1.09141  -6.35506  1.000 8.34404  ? 169  ARG A CB  1 
ATOM   805  C CG  . ARG A 1 88  ? 17.75393  -2.17610  -7.37517  1.000 8.49120  ? 169  ARG A CG  1 
ATOM   806  C CD  . ARG A 1 88  ? 16.53767  -3.01727  -7.02215  1.000 8.00459  ? 169  ARG A CD  1 
ATOM   807  N NE  . ARG A 1 88  ? 15.29260  -2.25016  -7.08296  1.000 7.81969  ? 169  ARG A NE  1 
ATOM   808  C CZ  . ARG A 1 88  ? 14.11522  -2.68214  -6.64422  1.000 7.65938  ? 169  ARG A CZ  1 
ATOM   809  N NH1 . ARG A 1 88  ? 13.97692  -3.88650  -6.11397  1.000 7.61832  ? 169  ARG A NH1 1 
ATOM   810  N NH2 . ARG A 1 88  ? 13.05460  -1.88105  -6.73263  1.000 8.80630  ? 169  ARG A NH2 1 
ATOM   811  N N   . ASP A 1 89  ? 19.51583  0.31635   -8.84957  1.000 7.93041  ? 170  ASP A N   1 
ATOM   812  C CA  . ASP A 1 89  ? 19.27003  1.13238   -10.04006 1.000 8.59386  ? 170  ASP A CA  1 
ATOM   813  C C   . ASP A 1 89  ? 20.05563  2.44288   -9.96990  1.000 8.85122  ? 170  ASP A C   1 
ATOM   814  O O   . ASP A 1 89  ? 19.49482  3.53359   -10.04669 1.000 11.67433 ? 170  ASP A O   1 
ATOM   815  C CB  . ASP A 1 89  ? 17.76393  1.39606   -10.21071 1.000 8.97572  ? 170  ASP A CB  1 
ATOM   816  C CG  . ASP A 1 89  ? 17.37017  1.75063   -11.63429 1.000 8.78549  ? 170  ASP A CG  1 
ATOM   817  O OD1 . ASP A 1 89  ? 18.11820  1.45262   -12.59121 1.000 11.67080 ? 170  ASP A OD1 1 
ATOM   818  O OD2 . ASP A 1 89  ? 16.27397  2.33588   -11.79640 1.000 12.17957 ? 170  ASP A OD2 1 
ATOM   819  N N   . CYS A 1 90  ? 21.38110  2.32671   -9.84420  1.000 7.97180  ? 171  CYS A N   1 
ATOM   820  C CA  . CYS A 1 90  ? 22.14386  3.50176   -9.43631  1.000 8.31278  ? 171  CYS A CA  1 
ATOM   821  C C   . CYS A 1 90  ? 22.26540  4.57574   -10.51495 1.000 7.93779  ? 171  CYS A C   1 
ATOM   822  O O   . CYS A 1 90  ? 22.57205  5.72312   -10.17952 1.000 9.68394  ? 171  CYS A O   1 
ATOM   823  C CB  . CYS A 1 90  ? 23.52198  3.12294   -8.88957  1.000 8.70061  ? 171  CYS A CB  1 
ATOM   824  S SG  . CYS A 1 90  ? 24.60104  2.27918   -10.07878 1.000 8.69552  ? 171  CYS A SG  1 
ATOM   825  N N   A ALA A 1 91  ? 22.07407  4.23193   -11.78662 0.687 8.51164  ? 172  ALA A N   1 
ATOM   826  N N   B ALA A 1 91  ? 21.97952  4.25873   -11.77767 0.313 8.57245  ? 172  ALA A N   1 
ATOM   827  C CA  A ALA A 1 91  ? 22.20866  5.19344   -12.87489 0.687 9.79763  ? 172  ALA A CA  1 
ATOM   828  C CA  B ALA A 1 91  ? 22.05781  5.24025   -12.85573 0.313 9.81577  ? 172  ALA A CA  1 
ATOM   829  C C   A ALA A 1 91  ? 20.86569  5.67146   -13.41486 0.687 9.95589  ? 172  ALA A C   1 
ATOM   830  C C   B ALA A 1 91  ? 20.69174  5.67171   -13.38239 0.313 9.43971  ? 172  ALA A C   1 
ATOM   831  O O   A ALA A 1 91  ? 20.82587  6.31422   -14.47105 0.687 10.38411 ? 172  ALA A O   1 
ATOM   832  O O   B ALA A 1 91  ? 20.62052  6.31666   -14.43543 0.313 10.06538 ? 172  ALA A O   1 
ATOM   833  C CB  A ALA A 1 91  ? 23.07481  4.62216   -14.00027 0.687 10.33016 ? 172  ALA A CB  1 
ATOM   834  C CB  B ALA A 1 91  ? 22.94213  4.72869   -13.99571 0.313 10.40579 ? 172  ALA A CB  1 
ATOM   835  N N   A ALA A 1 92  ? 19.77133  5.37352   -12.71887 0.687 9.61213  ? 173  ALA A N   1 
ATOM   836  N N   B ALA A 1 92  ? 19.61060  5.34331   -12.67874 0.313 10.15443 ? 173  ALA A N   1 
ATOM   837  C CA  A ALA A 1 92  ? 18.44224  5.81331   -13.12020 0.687 10.35676 ? 173  ALA A CA  1 
ATOM   838  C CA  B ALA A 1 92  ? 18.27200  5.69749   -13.13016 0.313 10.06708 ? 173  ALA A CA  1 
ATOM   839  C C   A ALA A 1 92  ? 17.61753  6.05351   -11.86290 0.687 10.44115 ? 173  ALA A C   1 
ATOM   840  C C   B ALA A 1 92  ? 17.31886  5.61770   -11.94688 0.313 9.60067  ? 173  ALA A C   1 
ATOM   841  O O   A ALA A 1 92  ? 18.08146  5.83665   -10.74224 0.687 11.41488 ? 173  ALA A O   1 
ATOM   842  O O   B ALA A 1 92  ? 17.43871  4.72481   -11.10772 0.313 10.68192 ? 173  ALA A O   1 
ATOM   843  C CB  A ALA A 1 92  ? 17.77876  4.79846   -14.05463 0.687 10.98573 ? 173  ALA A CB  1 
ATOM   844  C CB  B ALA A 1 92  ? 17.80394  4.76907   -14.25569 0.313 11.20526 ? 173  ALA A CB  1 
ATOM   845  N N   A LYS A 1 93  ? 16.37659  6.50379   -12.04880 0.687 10.51029 ? 174  LYS A N   1 
ATOM   846  N N   B LYS A 1 93  ? 16.36533  6.54529   -11.89484 0.313 11.22233 ? 174  LYS A N   1 
ATOM   847  C CA  A LYS A 1 93  ? 15.52061  6.83573   -10.91635 0.687 12.19862 ? 174  LYS A CA  1 
ATOM   848  C CA  B LYS A 1 93  ? 15.53908  6.71580   -10.70650 0.313 13.07773 ? 174  LYS A CA  1 
ATOM   849  C C   A LYS A 1 93  ? 14.30919  5.93032   -10.75185 0.687 11.03009 ? 174  LYS A C   1 
ATOM   850  C C   B LYS A 1 93  ? 14.33523  5.78191   -10.65212 0.313 10.10433 ? 174  LYS A C   1 
ATOM   851  O O   A LYS A 1 93  ? 13.70115  5.93325   -9.67675  0.687 14.40056 ? 174  LYS A O   1 
ATOM   852  O O   B LYS A 1 93  ? 13.74440  5.62704   -9.57564  0.313 11.82520 ? 174  LYS A O   1 
ATOM   853  C CB  A LYS A 1 93  ? 15.03828  8.29305   -11.00038 0.687 14.79970 ? 174  LYS A CB  1 
ATOM   854  C CB  B LYS A 1 93  ? 15.03983  8.16492   -10.61371 0.313 16.02835 ? 174  LYS A CB  1 
ATOM   855  C CG  A LYS A 1 93  ? 16.15608  9.32512   -11.00721 0.687 21.17968 ? 174  LYS A CG  1 
ATOM   856  C CG  B LYS A 1 93  ? 16.03343  9.21300   -11.11791 0.313 19.96021 ? 174  LYS A CG  1 
ATOM   857  C CD  A LYS A 1 93  ? 17.03307  9.21436   -9.75889  0.687 23.65562 ? 174  LYS A CD  1 
ATOM   858  C CD  B LYS A 1 93  ? 16.91191  9.81293   -10.01438 0.313 20.05552 ? 174  LYS A CD  1 
ATOM   859  C CE  A LYS A 1 93  ? 16.22487  9.35831   -8.46706  0.687 23.91612 ? 174  LYS A CE  1 
ATOM   860  C CE  B LYS A 1 93  ? 16.41814  9.48859   -8.60967  0.313 22.19209 ? 174  LYS A CE  1 
ATOM   861  N NZ  A LYS A 1 93  ? 15.17276  10.41399  -8.56016  0.687 26.40227 ? 174  LYS A NZ  1 
ATOM   862  N NZ  B LYS A 1 93  ? 15.37310  10.44144  -8.13964  0.313 23.47011 ? 174  LYS A NZ  1 
ATOM   863  N N   . ALA A 1 94  ? 13.95879  5.15145   -11.76988 1.000 8.57026  ? 175  ALA A N   1 
ATOM   864  C CA  . ALA A 1 94  ? 12.63501  4.54356   -11.83472 1.000 8.49198  ? 175  ALA A CA  1 
ATOM   865  C C   . ALA A 1 94  ? 12.45826  3.34530   -10.91403 1.000 8.93128  ? 175  ALA A C   1 
ATOM   866  O O   . ALA A 1 94  ? 11.32672  3.04675   -10.51181 1.000 8.82436  ? 175  ALA A O   1 
ATOM   867  C CB  . ALA A 1 94  ? 12.30908  4.16586   -13.27408 1.000 11.12640 ? 175  ALA A CB  1 
ATOM   868  N N   . SER A 1 95  ? 13.53431  2.63686   -10.58686 1.000 9.19818  ? 176  SER A N   1 
ATOM   869  C CA  . SER A 1 95  ? 13.42749  1.36943   -9.87585  1.000 8.73061  ? 176  SER A CA  1 
ATOM   870  C C   . SER A 1 95  ? 14.18936  1.36617   -8.55748  1.000 9.13483  ? 176  SER A C   1 
ATOM   871  O O   . SER A 1 95  ? 14.62154  0.31373   -8.08418  1.000 9.55835  ? 176  SER A O   1 
ATOM   872  C CB  . SER A 1 95  ? 13.80310  0.18455   -10.76112 1.000 9.23269  ? 176  SER A CB  1 
ATOM   873  O OG  . SER A 1 95  ? 12.75357  -0.06895  -11.68001 1.000 10.59496 ? 176  SER A OG  1 
ATOM   874  N N   . ASN A 1 96  ? 14.35615  2.53583   -7.94694  1.000 9.61158  ? 177  ASN A N   1 
ATOM   875  C CA  A ASN A 1 96  ? 14.88376  2.61647   -6.58902  0.461 10.66734 ? 177  ASN A CA  1 
ATOM   876  C CA  B ASN A 1 96  ? 14.91677  2.57277   -6.60817  0.539 10.72753 ? 177  ASN A CA  1 
ATOM   877  C C   . ASN A 1 96  ? 14.11465  1.65754   -5.68816  1.000 9.36467  ? 177  ASN A C   1 
ATOM   878  O O   . ASN A 1 96  ? 12.88629  1.55522   -5.78931  1.000 10.63262 ? 177  ASN A O   1 
ATOM   879  C CB  A ASN A 1 96  ? 14.70597  4.05194   -6.08453  0.461 12.29906 ? 177  ASN A CB  1 
ATOM   880  C CB  B ASN A 1 96  ? 14.94526  4.00806   -6.08648  0.539 12.81332 ? 177  ASN A CB  1 
ATOM   881  C CG  A ASN A 1 96  ? 15.39872  4.30466   -4.75640  0.461 15.50857 ? 177  ASN A CG  1 
ATOM   882  C CG  B ASN A 1 96  ? 15.86879  4.89880   -6.89739  0.539 13.72858 ? 177  ASN A CG  1 
ATOM   883  O OD1 A ASN A 1 96  ? 16.30253  3.57222   -4.36307  0.461 13.91485 ? 177  ASN A OD1 1 
ATOM   884  O OD1 B ASN A 1 96  ? 16.75601  4.41615   -7.60429  0.539 15.25861 ? 177  ASN A OD1 1 
ATOM   885  N ND2 A ASN A 1 96  ? 14.97658  5.35423   -4.06089  0.461 19.18918 ? 177  ASN A ND2 1 
ATOM   886  N ND2 B ASN A 1 96  ? 15.67228  6.20457   -6.79064  0.539 14.11752 ? 177  ASN A ND2 1 
ATOM   887  N N   . GLY A 1 97  ? 14.83183  0.95720   -4.80297  1.000 9.56017  ? 178  GLY A N   1 
ATOM   888  C CA  . GLY A 1 97  ? 14.25827  -0.09747  -4.00066  1.000 9.63194  ? 178  GLY A CA  1 
ATOM   889  C C   . GLY A 1 97  ? 14.18740  0.20222   -2.51303  1.000 8.12483  ? 178  GLY A C   1 
ATOM   890  O O   . GLY A 1 97  ? 14.45455  1.31312   -2.04848  1.000 9.61240  ? 178  GLY A O   1 
ATOM   891  N N   A GLU A 1 98  ? 13.85108  -0.84173  -1.75171  0.807 8.60721  ? 179  GLU A N   1 
ATOM   892  N N   B GLU A 1 98  ? 13.83338  -0.83870  -1.75595  0.193 8.64590  ? 179  GLU A N   1 
ATOM   893  C CA  A GLU A 1 98  ? 13.57516  -0.69286  -0.32578  0.807 9.28793  ? 179  GLU A CA  1 
ATOM   894  C CA  B GLU A 1 98  ? 13.58751  -0.67180  -0.32752  0.193 9.25808  ? 179  GLU A CA  1 
ATOM   895  C C   A GLU A 1 98  ? 14.82732  -0.63953  0.54192   0.807 8.05530  ? 179  GLU A C   1 
ATOM   896  C C   B GLU A 1 98  ? 14.87343  -0.45202  0.46183   0.193 8.90471  ? 179  GLU A C   1 
ATOM   897  O O   A GLU A 1 98  ? 14.72563  -0.24688  1.71247   0.807 9.46428  ? 179  GLU A O   1 
ATOM   898  O O   B GLU A 1 98  ? 14.85505  0.25740   1.47388   0.193 8.47430  ? 179  GLU A O   1 
ATOM   899  C CB  A GLU A 1 98  ? 12.68908  -1.83543  0.18180   0.807 9.08040  ? 179  GLU A CB  1 
ATOM   900  C CB  B GLU A 1 98  ? 12.80244  -1.86659  0.22408   0.193 9.14564  ? 179  GLU A CB  1 
ATOM   901  C CG  A GLU A 1 98  ? 13.35843  -3.19756  0.09220   0.807 8.71941  ? 179  GLU A CG  1 
ATOM   902  C CG  B GLU A 1 98  ? 13.57483  -3.18069  0.22989   0.193 7.54602  ? 179  GLU A CG  1 
ATOM   903  C CD  A GLU A 1 98  ? 12.43658  -4.36082  0.41582   0.807 7.86689  ? 179  GLU A CD  1 
ATOM   904  C CD  B GLU A 1 98  ? 12.78478  -4.33972  0.81595   0.193 8.85075  ? 179  GLU A CD  1 
ATOM   905  O OE1 A GLU A 1 98  ? 11.30959  -4.14293  0.93177   0.807 10.08519 ? 179  GLU A OE1 1 
ATOM   906  O OE1 B GLU A 1 98  ? 11.67507  -4.11036  1.34733   0.193 8.37979  ? 179  GLU A OE1 1 
ATOM   907  O OE2 A GLU A 1 98  ? 12.84049  -5.49949  0.12534   0.807 7.38547  ? 179  GLU A OE2 1 
ATOM   908  O OE2 B GLU A 1 98  ? 13.27374  -5.48699  0.73816   0.193 11.03775 ? 179  GLU A OE2 1 
ATOM   909  N N   . PHE A 1 99  ? 15.99013  -1.03257  0.02468   1.000 8.63159  ? 180  PHE A N   1 
ATOM   910  C CA  . PHE A 1 99  ? 17.22042  -1.00045  0.80382   1.000 8.74203  ? 180  PHE A CA  1 
ATOM   911  C C   . PHE A 1 99  ? 18.10444  0.15474   0.35587   1.000 8.24967  ? 180  PHE A C   1 
ATOM   912  O O   . PHE A 1 99  ? 18.23475  0.43359   -0.84398  1.000 9.17199  ? 180  PHE A O   1 
ATOM   913  C CB  . PHE A 1 99  ? 18.01458  -2.30417  0.67054   1.000 9.03029  ? 180  PHE A CB  1 
ATOM   914  C CG  . PHE A 1 99  ? 17.33749  -3.52884  1.24098   1.000 8.65861  ? 180  PHE A CG  1 
ATOM   915  C CD1 . PHE A 1 99  ? 16.49336  -3.46316  2.33913   1.000 9.45146  ? 180  PHE A CD1 1 
ATOM   916  C CD2 . PHE A 1 99  ? 17.60288  -4.77082  0.68165   1.000 9.69240  ? 180  PHE A CD2 1 
ATOM   917  C CE1 . PHE A 1 99  ? 15.88727  -4.62734  2.84288   1.000 10.56533 ? 180  PHE A CE1 1 
ATOM   918  C CE2 . PHE A 1 99  ? 17.02001  -5.92569  1.17539   1.000 10.12232 ? 180  PHE A CE2 1 
ATOM   919  C CZ  . PHE A 1 99  ? 16.16099  -5.85698  2.26279   1.000 10.62610 ? 180  PHE A CZ  1 
ATOM   920  N N   . SER A 1 100 ? 18.72443  0.81467   1.32796   1.000 9.23350  ? 181  SER A N   1 
ATOM   921  C CA  A SER A 1 100 ? 19.66930  1.88982   1.07316   0.395 9.43331  ? 181  SER A CA  1 
ATOM   922  C CA  B SER A 1 100 ? 19.67914  1.87220   1.05385   0.605 9.39829  ? 181  SER A CA  1 
ATOM   923  C C   . SER A 1 100 ? 20.93455  1.61763   1.87200   1.000 8.55742  ? 181  SER A C   1 
ATOM   924  O O   . SER A 1 100 ? 20.87499  1.06486   2.97240   1.000 9.47621  ? 181  SER A O   1 
ATOM   925  C CB  A SER A 1 100 ? 19.08306  3.23879   1.48877   0.395 12.22911 ? 181  SER A CB  1 
ATOM   926  C CB  B SER A 1 100 ? 19.11697  3.26018   1.39388   0.605 12.32674 ? 181  SER A CB  1 
ATOM   927  O OG  A SER A 1 100 ? 18.05672  3.63241   0.59704   0.395 13.75951 ? 181  SER A OG  1 
ATOM   928  O OG  B SER A 1 100 ? 19.00490  3.44509   2.79334   0.605 17.62477 ? 181  SER A OG  1 
ATOM   929  N N   A ILE A 1 101 ? 22.08581  2.00003   1.31132   0.674 9.21705  ? 182  ILE A N   1 
ATOM   930  N N   B ILE A 1 101 ? 22.07672  2.02562   1.31559   0.326 9.27031  ? 182  ILE A N   1 
ATOM   931  C CA  A ILE A 1 101 ? 23.37038  1.68618   1.94379   0.674 9.80460  ? 182  ILE A CA  1 
ATOM   932  C CA  B ILE A 1 101 ? 23.33155  1.90239   2.04873   0.326 10.02671 ? 182  ILE A CA  1 
ATOM   933  C C   A ILE A 1 101 ? 23.40671  2.14102   3.39938   0.674 8.21738  ? 182  ILE A C   1 
ATOM   934  C C   B ILE A 1 101 ? 23.31815  2.76939   3.30095   0.326 11.35203 ? 182  ILE A C   1 
ATOM   935  O O   A ILE A 1 101 ? 23.85715  1.40464   4.28582   0.674 8.90607  ? 182  ILE A O   1 
ATOM   936  O O   B ILE A 1 101 ? 23.90380  2.40089   4.32591   0.326 12.28181 ? 182  ILE A O   1 
ATOM   937  C CB  A ILE A 1 101 ? 24.53424  2.26428   1.11621   0.674 10.60309 ? 182  ILE A CB  1 
ATOM   938  C CB  B ILE A 1 101 ? 24.53943  2.18121   1.12967   0.326 10.58643 ? 182  ILE A CB  1 
ATOM   939  C CG1 A ILE A 1 101 ? 24.73747  1.42306   -0.14163  0.674 9.51486  ? 182  ILE A CG1 1 
ATOM   940  C CG1 B ILE A 1 101 ? 24.39751  1.39760   -0.17915  0.326 8.96673  ? 182  ILE A CG1 1 
ATOM   941  C CG2 A ILE A 1 101 ? 25.82300  2.34139   1.94123   0.674 10.32182 ? 182  ILE A CG2 1 
ATOM   942  C CG2 B ILE A 1 101 ? 25.85016  1.83400   1.82892   0.326 12.22526 ? 182  ILE A CG2 1 
ATOM   943  C CD1 A ILE A 1 101 ? 25.83064  1.93373   -1.04554  0.674 11.49489 ? 182  ILE A CD1 1 
ATOM   944  C CD1 B ILE A 1 101 ? 25.30693  1.87539   -1.29186  0.326 10.15622 ? 182  ILE A CD1 1 
ATOM   945  N N   A ALA A 1 102 ? 22.91358  3.34904   3.67420   0.674 8.72788  ? 183  ALA A N   1 
ATOM   946  N N   B ALA A 1 102 ? 22.63235  3.91186   3.25678   0.326 9.82787  ? 183  ALA A N   1 
ATOM   947  C CA  A ALA A 1 102 ? 22.98557  3.88967   5.02871   0.674 10.13475 ? 183  ALA A CA  1 
ATOM   948  C CA  B ALA A 1 102 ? 22.56167  4.78618   4.42089   0.326 11.14721 ? 183  ALA A CA  1 
ATOM   949  C C   A ALA A 1 102 ? 22.06410  3.17726   6.01232   0.674 8.73012  ? 183  ALA A C   1 
ATOM   950  C C   B ALA A 1 102 ? 21.59649  4.29458   5.49143   0.326 11.50129 ? 183  ALA A C   1 
ATOM   951  O O   A ALA A 1 102 ? 22.30622  3.24197   7.22205   0.674 11.00854 ? 183  ALA A O   1 
ATOM   952  O O   B ALA A 1 102 ? 21.60569  4.83996   6.60025   0.326 11.79629 ? 183  ALA A O   1 
ATOM   953  C CB  A ALA A 1 102 ? 22.66597  5.38298   5.01883   0.674 12.67504 ? 183  ALA A CB  1 
ATOM   954  C CB  B ALA A 1 102 ? 22.18932  6.21159   4.00631   0.326 10.83981 ? 183  ALA A CB  1 
ATOM   955  N N   A ASN A 1 103 ? 21.01255  2.51920   5.53509   0.674 8.62775  ? 184  ASN A N   1 
ATOM   956  N N   B ASN A 1 103 ? 20.76602  3.29253   5.19933   0.326 8.08115  ? 184  ASN A N   1 
ATOM   957  C CA  A ASN A 1 103 ? 20.04008  1.86437   6.41394   0.674 9.14792  ? 184  ASN A CA  1 
ATOM   958  C CA  B ASN A 1 103 ? 19.82881  2.75382   6.18360   0.326 8.65037  ? 184  ASN A CA  1 
ATOM   959  C C   A ASN A 1 103 ? 20.36969  0.37771   6.56739   0.674 8.08695  ? 184  ASN A C   1 
ATOM   960  C C   B ASN A 1 103 ? 20.00030  1.23602   6.29303   0.326 9.64762  ? 184  ASN A C   1 
ATOM   961  O O   A ASN A 1 103 ? 19.56630  -0.48083  6.23472   0.674 7.93460  ? 184  ASN A O   1 
ATOM   962  O O   B ASN A 1 103 ? 19.06871  0.45858   6.08688   0.326 11.20273 ? 184  ASN A O   1 
ATOM   963  C CB  A ASN A 1 103 ? 18.61224  2.05457   5.88019   0.674 10.39940 ? 184  ASN A CB  1 
ATOM   964  C CB  B ASN A 1 103 ? 18.39023  3.18191   5.89746   0.326 12.59861 ? 184  ASN A CB  1 
ATOM   965  C CG  A ASN A 1 103 ? 18.18030  3.52056   5.79054   0.674 10.13267 ? 184  ASN A CG  1 
ATOM   966  C CG  B ASN A 1 103 ? 18.20650  4.68508   6.00204   0.326 12.23653 ? 184  ASN A CG  1 
ATOM   967  O OD1 A ASN A 1 103 ? 18.75559  4.39481   6.43630   0.674 15.52972 ? 184  ASN A OD1 1 
ATOM   968  O OD1 B ASN A 1 103 ? 18.39785  5.41270   5.03018   0.326 14.00620 ? 184  ASN A OD1 1 
ATOM   969  N ND2 A ASN A 1 103 ? 17.12829  3.78082   5.01228   0.674 12.62919 ? 184  ASN A ND2 1 
ATOM   970  N ND2 B ASN A 1 103 ? 17.88015  5.16047   7.19443   0.326 9.77021  ? 184  ASN A ND2 1 
ATOM   971  N N   A ASN A 1 104 ? 21.56831  0.07121   7.07936   0.674 9.48082  ? 185  ASN A N   1 
ATOM   972  N N   B ASN A 1 104 ? 21.22911  0.82132   6.60780   0.326 12.32011 ? 185  ASN A N   1 
ATOM   973  C CA  A ASN A 1 104 ? 22.04576  -1.31588  7.18407   0.674 8.72333  ? 185  ASN A CA  1 
ATOM   974  C CA  B ASN A 1 104 ? 21.54893  -0.57642  6.91035   0.326 12.39403 ? 185  ASN A CA  1 
ATOM   975  C C   A ASN A 1 104 ? 21.86761  -2.05772  5.86191   0.674 6.92799  ? 185  ASN A C   1 
ATOM   976  C C   B ASN A 1 104 ? 21.28266  -1.50920  5.72866   0.326 11.03775 ? 185  ASN A C   1 
ATOM   977  O O   A ASN A 1 104 ? 21.49593  -3.22615  5.84336   0.674 8.00650  ? 185  ASN A O   1 
ATOM   978  O O   B ASN A 1 104 ? 20.79666  -2.62427  5.90049   0.326 11.65507 ? 185  ASN A O   1 
ATOM   979  C CB  A ASN A 1 104 ? 21.32231  -2.10061  8.28878   0.674 8.96568  ? 185  ASN A CB  1 
ATOM   980  C CB  B ASN A 1 104 ? 20.82610  -1.06436  8.17003   0.326 14.16282 ? 185  ASN A CB  1 
ATOM   981  C CG  A ASN A 1 104 ? 21.76197  -1.74163  9.69181   0.674 8.71553  ? 185  ASN A CG  1 
ATOM   982  C CG  B ASN A 1 104 ? 21.78223  -1.50703  9.25631   0.326 15.26260 ? 185  ASN A CG  1 
ATOM   983  O OD1 A ASN A 1 104 ? 22.83824  -1.18828  9.91580   0.674 10.85189 ? 185  ASN A OD1 1 
ATOM   984  O OD1 B ASN A 1 104 ? 22.37362  -0.68195  9.95149   0.326 12.69872 ? 185  ASN A OD1 1 
ATOM   985  N ND2 A ASN A 1 104 ? 20.92013  -2.09345  10.66251  0.674 9.21231  ? 185  ASN A ND2 1 
ATOM   986  N ND2 B ASN A 1 104 ? 21.93642  -2.81790  9.41203   0.326 15.79044 ? 185  ASN A ND2 1 
ATOM   987  N N   A GLY A 1 105 ? 22.13034  -1.37368  4.74440   0.674 7.18584  ? 186  GLY A N   1 
ATOM   988  N N   B GLY A 1 105 ? 21.62383  -1.07365  4.52086   0.326 8.90788  ? 186  GLY A N   1 
ATOM   989  C CA  A GLY A 1 105 ? 21.72377  -1.90807  3.45058   0.674 8.38315  ? 186  GLY A CA  1 
ATOM   990  C CA  B GLY A 1 105 ? 21.28507  -1.85746  3.34640   0.326 8.92353  ? 186  GLY A CA  1 
ATOM   991  C C   A GLY A 1 105 ? 22.37287  -3.23573  3.11550   0.674 7.29985  ? 186  GLY A C   1 
ATOM   992  C C   B GLY A 1 105 ? 22.04050  -3.15161  3.11570   0.326 8.00720  ? 186  GLY A C   1 
ATOM   993  O O   A GLY A 1 105 ? 21.69183  -4.19887  2.75307   0.674 7.86759  ? 186  GLY A O   1 
ATOM   994  O O   B GLY A 1 105 ? 21.42689  -4.16013  2.75265   0.326 8.02406  ? 186  GLY A O   1 
ATOM   995  N N   A GLN A 1 106 ? 23.70295  -3.29880  3.20371   0.674 7.88310  ? 187  GLN A N   1 
ATOM   996  N N   B GLN A 1 106 ? 23.36467  -3.13972  3.29907   0.326 10.56775 ? 187  GLN A N   1 
ATOM   997  C CA  A GLN A 1 106 ? 24.38982  -4.53468  2.85967   0.674 8.89057  ? 187  GLN A CA  1 
ATOM   998  C CA  B GLN A 1 106 ? 24.18266  -4.29670  2.93103   0.326 9.90089  ? 187  GLN A CA  1 
ATOM   999  C C   A GLN A 1 106 ? 23.98167  -5.66465  3.79052   0.674 8.40059  ? 187  GLN A C   1 
ATOM   1000 C C   B GLN A 1 106 ? 23.83200  -5.52497  3.76943   0.326 9.04522  ? 187  GLN A C   1 
ATOM   1001 O O   A GLN A 1 106 ? 23.75533  -6.79441  3.34057   0.674 8.89899  ? 187  GLN A O   1 
ATOM   1002 O O   B GLN A 1 106 ? 23.54864  -6.60057  3.23151   0.326 9.49832  ? 187  GLN A O   1 
ATOM   1003 C CB  A GLN A 1 106 ? 25.89759  -4.32835  2.89587   0.674 9.38129  ? 187  GLN A CB  1 
ATOM   1004 C CB  B GLN A 1 106 ? 25.66852  -3.94763  3.05318   0.326 10.59769 ? 187  GLN A CB  1 
ATOM   1005 C CG  A GLN A 1 106 ? 26.66777  -5.53739  2.45974   0.674 8.83559  ? 187  GLN A CG  1 
ATOM   1006 C CG  B GLN A 1 106 ? 26.59044  -4.87738  2.28355   0.326 11.80912 ? 187  GLN A CG  1 
ATOM   1007 C CD  A GLN A 1 106 ? 28.13109  -5.23117  2.31781   0.674 9.23428  ? 187  GLN A CD  1 
ATOM   1008 C CD  B GLN A 1 106 ? 28.02689  -4.38648  2.23585   0.326 13.05527 ? 187  GLN A CD  1 
ATOM   1009 O OE1 A GLN A 1 106 ? 28.50909  -4.22296  1.72259   0.674 11.47013 ? 187  GLN A OE1 1 
ATOM   1010 O OE1 B GLN A 1 106 ? 28.29002  -3.19011  2.10520   0.326 9.65516  ? 187  GLN A OE1 1 
ATOM   1011 N NE2 A GLN A 1 106 ? 28.97111  -6.08819  2.87964   0.674 8.58158  ? 187  GLN A NE2 1 
ATOM   1012 N NE2 B GLN A 1 106 ? 28.96774  -5.31841  2.33321   0.326 11.84585 ? 187  GLN A NE2 1 
ATOM   1013 N N   . ALA A 1 107 ? 23.86421  -5.37982  5.09448   1.000 9.13098  ? 188  ALA A N   1 
ATOM   1014 C CA  . ALA A 1 107 ? 23.45111  -6.44682  6.00179   1.000 9.91267  ? 188  ALA A CA  1 
ATOM   1015 C C   . ALA A 1 107 ? 22.02347  -6.89012  5.71766   1.000 9.39636  ? 188  ALA A C   1 
ATOM   1016 O O   . ALA A 1 107 ? 21.72452  -8.09031  5.72919   1.000 9.96112  ? 188  ALA A O   1 
ATOM   1017 C CB  . ALA A 1 107 ? 23.60052  -5.99377  7.45237   1.000 10.20691 ? 188  ALA A CB  1 
ATOM   1018 N N   . ASN A 1 108 ? 21.12641  -5.93982  5.45180   1.000 9.17293  ? 189  ASN A N   1 
ATOM   1019 C CA  . ASN A 1 108 ? 19.75912  -6.31735  5.09609   1.000 9.30988  ? 189  ASN A CA  1 
ATOM   1020 C C   . ASN A 1 108 ? 19.71711  -7.13422  3.82145   1.000 8.45881  ? 189  ASN A C   1 
ATOM   1021 O O   . ASN A 1 108 ? 18.91354  -8.06817  3.70219   1.000 8.41734  ? 189  ASN A O   1 
ATOM   1022 C CB  . ASN A 1 108 ? 18.84165  -5.11173  4.93730   1.000 10.98309 ? 189  ASN A CB  1 
ATOM   1023 C CG  . ASN A 1 108 ? 18.61948  -4.37463  6.22044   1.000 10.43792 ? 189  ASN A CG  1 
ATOM   1024 O OD1 . ASN A 1 108 ? 18.85193  -4.90647  7.30066   1.000 12.11537 ? 189  ASN A OD1 1 
ATOM   1025 N ND2 . ASN A 1 108 ? 18.10978  -3.15355  6.11863   1.000 12.95200 ? 189  ASN A ND2 1 
ATOM   1026 N N   . TYR A 1 109 ? 20.53679  -6.77309  2.84018   1.000 7.94636  ? 190  TYR A N   1 
ATOM   1027 C CA  . TYR A 1 109 ? 20.56349  -7.54210  1.61084   1.000 7.63719  ? 190  TYR A CA  1 
ATOM   1028 C C   . TYR A 1 109 ? 21.03320  -8.96197  1.87429   1.000 7.94273  ? 190  TYR A C   1 
ATOM   1029 O O   . TYR A 1 109 ? 20.47424  -9.91901  1.33410   1.000 7.93094  ? 190  TYR A O   1 
ATOM   1030 C CB  . TYR A 1 109 ? 21.46159  -6.87755  0.57952   1.000 7.60386  ? 190  TYR A CB  1 
ATOM   1031 C CG  . TYR A 1 109 ? 21.42948  -7.60437  -0.73073  1.000 7.72179  ? 190  TYR A CG  1 
ATOM   1032 C CD1 . TYR A 1 109 ? 20.42953  -7.35431  -1.64572  1.000 7.48458  ? 190  TYR A CD1 1 
ATOM   1033 C CD2 . TYR A 1 109 ? 22.37530  -8.57620  -1.04528  1.000 7.18745  ? 190  TYR A CD2 1 
ATOM   1034 C CE1 . TYR A 1 109 ? 20.37814  -8.01165  -2.84679  1.000 7.60045  ? 190  TYR A CE1 1 
ATOM   1035 C CE2 . TYR A 1 109 ? 22.32748  -9.24845  -2.25135  1.000 7.24852  ? 190  TYR A CE2 1 
ATOM   1036 C CZ  . TYR A 1 109 ? 21.32539  -8.96156  -3.15415  1.000 6.57533  ? 190  TYR A CZ  1 
ATOM   1037 O OH  . TYR A 1 109 ? 21.30258  -9.62625  -4.36034  1.000 7.73717  ? 190  TYR A OH  1 
ATOM   1038 N N   A GLU A 1 110 ? 22.12306  -9.12091  2.61279   0.563 8.27747  ? 191  GLU A N   1 
ATOM   1039 N N   B GLU A 1 110 ? 22.03857  -9.12485  2.75146   0.437 8.84366  ? 191  GLU A N   1 
ATOM   1040 C CA  A GLU A 1 110 ? 22.64054  -10.46996 2.78555   0.563 7.50918  ? 191  GLU A CA  1 
ATOM   1041 C CA  B GLU A 1 110 ? 22.41023  -10.47354 3.17779   0.437 10.25016 ? 191  GLU A CA  1 
ATOM   1042 C C   A GLU A 1 110 ? 21.66351  -11.33436 3.57355   0.563 7.45205  ? 191  GLU A C   1 
ATOM   1043 C C   B GLU A 1 110 ? 21.26473  -11.18042 3.89656   0.437 9.03180  ? 191  GLU A C   1 
ATOM   1044 O O   A GLU A 1 110 ? 21.56356  -12.54388 3.33439   0.563 6.50452  ? 191  GLU A O   1 
ATOM   1045 O O   B GLU A 1 110 ? 21.07404  -12.38451 3.71633   0.437 8.19847  ? 191  GLU A O   1 
ATOM   1046 C CB  A GLU A 1 110 ? 24.04983  -10.40657 3.35177   0.563 7.25831  ? 191  GLU A CB  1 
ATOM   1047 C CB  B GLU A 1 110 ? 23.72582  -10.55237 3.97598   0.437 12.11599 ? 191  GLU A CB  1 
ATOM   1048 C CG  A GLU A 1 110 ? 24.98286  -9.87003  2.27878   0.563 9.08157  ? 191  GLU A CG  1 
ATOM   1049 C CG  B GLU A 1 110 ? 24.50014  -9.29479  4.31592   0.437 14.80547 ? 191  GLU A CG  1 
ATOM   1050 C CD  A GLU A 1 110 ? 26.41006  -9.69315  2.70955   0.563 7.98137  ? 191  GLU A CD  1 
ATOM   1051 C CD  B GLU A 1 110 ? 25.79957  -9.61044  5.06496   0.437 11.82219 ? 191  GLU A CD  1 
ATOM   1052 O OE1 A GLU A 1 110 ? 26.78317  -10.13614 3.81349   0.563 9.27753  ? 191  GLU A OE1 1 
ATOM   1053 O OE1 B GLU A 1 110 ? 25.75355  -10.42285 6.01589   0.437 13.45369 ? 191  GLU A OE1 1 
ATOM   1054 O OE2 A GLU A 1 110 ? 27.18196  -9.16695  1.88138   0.563 9.80092  ? 191  GLU A OE2 1 
ATOM   1055 O OE2 B GLU A 1 110 ? 26.85611  -9.03780  4.72022   0.437 12.84693 ? 191  GLU A OE2 1 
ATOM   1056 N N   A ASN A 1 111 ? 20.87662  -10.71282 4.45178   0.563 6.92435  ? 192  ASN A N   1 
ATOM   1057 N N   B ASN A 1 111 ? 20.48394  -10.45852 4.70665   0.437 9.17983  ? 192  ASN A N   1 
ATOM   1058 C CA  A ASN A 1 111 ? 19.80791  -11.42643 5.14181   0.563 7.68807  ? 192  ASN A CA  1 
ATOM   1059 C CA  B ASN A 1 111 ? 19.31294  -11.08664 5.31737   0.437 8.16385  ? 192  ASN A CA  1 
ATOM   1060 C C   A ASN A 1 111 ? 18.65746  -11.77414 4.19597   0.563 6.64049  ? 192  ASN A C   1 
ATOM   1061 C C   B ASN A 1 111 ? 18.29430  -11.51088 4.26615   0.437 9.13948  ? 192  ASN A C   1 
ATOM   1062 O O   A ASN A 1 111 ? 18.04762  -12.84558 4.32428   0.563 6.16930  ? 192  ASN A O   1 
ATOM   1063 O O   B ASN A 1 111 ? 17.61616  -12.53239 4.42744   0.437 9.10161  ? 192  ASN A O   1 
ATOM   1064 C CB  A ASN A 1 111 ? 19.32326  -10.59206 6.32535   0.563 6.70327  ? 192  ASN A CB  1 
ATOM   1065 C CB  B ASN A 1 111 ? 18.68306  -10.15202 6.35040   0.437 10.20159 ? 192  ASN A CB  1 
ATOM   1066 C CG  A ASN A 1 111 ? 18.07605  -11.15263 6.94944   0.563 8.16610  ? 192  ASN A CG  1 
ATOM   1067 C CG  B ASN A 1 111 ? 17.40459  -10.71351 6.94284   0.437 10.88135 ? 192  ASN A CG  1 
ATOM   1068 O OD1 A ASN A 1 111 ? 16.96793  -10.68558 6.67608   0.563 7.95671  ? 192  ASN A OD1 1 
ATOM   1069 O OD1 B ASN A 1 111 ? 16.30630  -10.31621 6.55651   0.437 13.29042 ? 192  ASN A OD1 1 
ATOM   1070 N ND2 A ASN A 1 111 ? 18.23507  -12.18699 7.77080   0.563 8.50026  ? 192  ASN A ND2 1 
ATOM   1071 N ND2 B ASN A 1 111 ? 17.54061  -11.65010 7.87574   0.437 13.74053 ? 192  ASN A ND2 1 
ATOM   1072 N N   A TYR A 1 112 ? 18.32006  -10.86112 3.27159   0.563 8.02779  ? 193  TYR A N   1 
ATOM   1073 N N   B TYR A 1 112 ? 18.19316  -10.75160 3.17703   0.437 7.41505  ? 193  TYR A N   1 
ATOM   1074 C CA  A TYR A 1 112 ? 17.37784  -11.15997 2.19034   0.563 8.01432  ? 193  TYR A CA  1 
ATOM   1075 C CA  B TYR A 1 112 ? 17.30913  -11.11504 2.07538   0.437 7.22702  ? 193  TYR A CA  1 
ATOM   1076 C C   A TYR A 1 112 ? 17.81847  -12.41282 1.44222   0.563 6.54192  ? 193  TYR A C   1 
ATOM   1077 C C   B TYR A 1 112 ? 17.79775  -12.38715 1.37466   0.437 6.69197  ? 193  TYR A C   1 
ATOM   1078 O O   A TYR A 1 112 ? 17.02795  -13.34046 1.23017   0.563 6.76147  ? 193  TYR A O   1 
ATOM   1079 O O   B TYR A 1 112 ? 17.01069  -13.31138 1.13306   0.437 7.15094  ? 193  TYR A O   1 
ATOM   1080 C CB  A TYR A 1 112 ? 17.24637  -9.91461  1.28712   0.563 7.62520  ? 193  TYR A CB  1 
ATOM   1081 C CB  B TYR A 1 112 ? 17.15937  -9.89087  1.15966   0.437 7.44275  ? 193  TYR A CB  1 
ATOM   1082 C CG  A TYR A 1 112 ? 16.86614  -10.08280 -0.18645  0.563 6.52300  ? 193  TYR A CG  1 
ATOM   1083 C CG  B TYR A 1 112 ? 16.83311  -10.10120 -0.29914  0.437 6.44805  ? 193  TYR A CG  1 
ATOM   1084 C CD1 A TYR A 1 112 ? 17.85048  -10.27582 -1.14996  0.563 7.27051  ? 193  TYR A CD1 1 
ATOM   1085 C CD1 B TYR A 1 112 ? 17.84504  -10.29830 -1.22717  0.437 7.35429  ? 193  TYR A CD1 1 
ATOM   1086 C CD2 A TYR A 1 112 ? 15.54503  -9.95925  -0.62438  0.563 7.34339  ? 193  TYR A CD2 1 
ATOM   1087 C CD2 B TYR A 1 112 ? 15.52248  -10.03319 -0.76034  0.437 6.84372  ? 193  TYR A CD2 1 
ATOM   1088 C CE1 A TYR A 1 112 ? 17.53547  -10.39181 -2.50058  0.563 7.17043  ? 193  TYR A CE1 1 
ATOM   1089 C CE1 B TYR A 1 112 ? 17.56401  -10.45736 -2.56968  0.437 7.07328  ? 193  TYR A CE1 1 
ATOM   1090 C CE2 A TYR A 1 112 ? 15.22037  -10.07329 -1.98288  0.563 6.80458  ? 193  TYR A CE2 1 
ATOM   1091 C CE2 B TYR A 1 112 ? 15.23059  -10.18933 -2.10338  0.437 6.87304  ? 193  TYR A CE2 1 
ATOM   1092 C CZ  A TYR A 1 112 ? 16.21924  -10.29039 -2.91126  0.563 6.51963  ? 193  TYR A CZ  1 
ATOM   1093 C CZ  B TYR A 1 112 ? 16.25361  -10.40189 -3.00169  0.437 6.66006  ? 193  TYR A CZ  1 
ATOM   1094 O OH  A TYR A 1 112 ? 15.93564  -10.41030 -4.25104  0.563 7.14529  ? 193  TYR A OH  1 
ATOM   1095 O OH  B TYR A 1 112 ? 15.99003  -10.56826 -4.33751  0.437 6.27614  ? 193  TYR A OH  1 
ATOM   1096 N N   . ILE A 1 113 ? 19.10616  -12.48306 1.09776   1.000 7.43951  ? 194  ILE A N   1 
ATOM   1097 C CA  . ILE A 1 113 ? 19.65541  -13.70675 0.51182   1.000 7.12832  ? 194  ILE A CA  1 
ATOM   1098 C C   . ILE A 1 113 ? 19.47295  -14.88738 1.45928   1.000 7.12081  ? 194  ILE A C   1 
ATOM   1099 O O   . ILE A 1 113 ? 19.06569  -15.97491 1.03999   1.000 7.18828  ? 194  ILE A O   1 
ATOM   1100 C CB  . ILE A 1 113 ? 21.13416  -13.51412 0.11959   1.000 7.18420  ? 194  ILE A CB  1 
ATOM   1101 C CG1 . ILE A 1 113 ? 21.28047  -12.46618 -0.98948  1.000 7.74930  ? 194  ILE A CG1 1 
ATOM   1102 C CG2 . ILE A 1 113 ? 21.76763  -14.84185 -0.27562  1.000 7.98732  ? 194  ILE A CG2 1 
ATOM   1103 C CD1 . ILE A 1 113 ? 20.54008  -12.76489 -2.27013  1.000 7.20522  ? 194  ILE A CD1 1 
ATOM   1104 N N   . ASP A 1 114 ? 19.78085  -14.69817 2.74676   1.000 7.33270  ? 195  ASP A N   1 
ATOM   1105 C CA  . ASP A 1 114 ? 19.66163  -15.80160 3.69633   1.000 8.01594  ? 195  ASP A CA  1 
ATOM   1106 C C   . ASP A 1 114 ? 18.23487  -16.33962 3.74326   1.000 7.42627  ? 195  ASP A C   1 
ATOM   1107 O O   . ASP A 1 114 ? 18.02375  -17.55429 3.83528   1.000 7.30503  ? 195  ASP A O   1 
ATOM   1108 C CB  . ASP A 1 114 ? 20.08824  -15.35242 5.09244   1.000 9.17979  ? 195  ASP A CB  1 
ATOM   1109 C CG  . ASP A 1 114 ? 21.58389  -15.09729 5.20693   1.000 10.38856 ? 195  ASP A CG  1 
ATOM   1110 O OD1 . ASP A 1 114 ? 22.35964  -15.54359 4.33770   1.000 9.69434  ? 195  ASP A OD1 1 
ATOM   1111 O OD2 . ASP A 1 114 ? 21.96986  -14.44988 6.20000   1.000 11.65152 ? 195  ASP A OD2 1 
ATOM   1112 N N   A GLN A 1 115 ? 17.24380  -15.44702 3.69983   0.673 7.71044  ? 196  GLN A N   1 
ATOM   1113 N N   B GLN A 1 115 ? 17.23964  -15.45376 3.67964   0.327 7.67549  ? 196  GLN A N   1 
ATOM   1114 C CA  A GLN A 1 115 ? 15.85023  -15.88109 3.70808   0.673 7.79125  ? 196  GLN A CA  1 
ATOM   1115 C CA  B GLN A 1 115 ? 15.85360  -15.91184 3.72398   0.327 7.89829  ? 196  GLN A CA  1 
ATOM   1116 C C   A GLN A 1 115 ? 15.50589  -16.66577 2.45300   0.673 6.61235  ? 196  GLN A C   1 
ATOM   1117 C C   B GLN A 1 115 ? 15.45280  -16.62940 2.44027   0.327 6.56292  ? 196  GLN A C   1 
ATOM   1118 O O   A GLN A 1 115 ? 14.77196  -17.66081 2.51598   0.673 7.07930  ? 196  GLN A O   1 
ATOM   1119 O O   B GLN A 1 115 ? 14.62629  -17.54822 2.47628   0.327 7.54733  ? 196  GLN A O   1 
ATOM   1120 C CB  A GLN A 1 115 ? 14.93175  -14.67425 3.81966   0.673 8.15384  ? 196  GLN A CB  1 
ATOM   1121 C CB  B GLN A 1 115 ? 14.91934  -14.73918 4.01036   0.327 8.71964  ? 196  GLN A CB  1 
ATOM   1122 C CG  A GLN A 1 115 ? 14.99874  -13.96169 5.14308   0.673 8.83634  ? 196  GLN A CG  1 
ATOM   1123 C CG  B GLN A 1 115 ? 14.93684  -14.28731 5.46204   0.327 8.53819  ? 196  GLN A CG  1 
ATOM   1124 C CD  A GLN A 1 115 ? 14.03595  -12.80535 5.18097   0.673 9.60364  ? 196  GLN A CD  1 
ATOM   1125 C CD  B GLN A 1 115 ? 13.82326  -13.31003 5.77589   0.327 9.16192  ? 196  GLN A CD  1 
ATOM   1126 O OE1 A GLN A 1 115 ? 12.84270  -12.96859 4.91599   0.673 10.17324 ? 196  GLN A OE1 1 
ATOM   1127 O OE1 B GLN A 1 115 ? 12.64412  -13.63195 5.63081   0.327 10.64891 ? 196  GLN A OE1 1 
ATOM   1128 N NE2 A GLN A 1 115 ? 14.54456  -11.62287 5.47856   0.673 10.22036 ? 196  GLN A NE2 1 
ATOM   1129 N NE2 B GLN A 1 115 ? 14.19007  -12.10437 6.19579   0.327 12.84730 ? 196  GLN A NE2 1 
ATOM   1130 N N   . ILE A 1 116 ? 16.02534  -16.22485 1.30693   1.000 7.21234  ? 197  ILE A N   1 
ATOM   1131 C CA  . ILE A 1 116 ? 15.81019  -16.93287 0.04852   1.000 7.12673  ? 197  ILE A CA  1 
ATOM   1132 C C   . ILE A 1 116 ? 16.45695  -18.31429 0.09500   1.000 6.60129  ? 197  ILE A C   1 
ATOM   1133 O O   . ILE A 1 116 ? 15.83785  -19.31624 -0.27143  1.000 7.10557  ? 197  ILE A O   1 
ATOM   1134 C CB  . ILE A 1 116 ? 16.32822  -16.07550 -1.12202  1.000 6.80150  ? 197  ILE A CB  1 
ATOM   1135 C CG1 . ILE A 1 116 ? 15.39473  -14.87490 -1.33205  1.000 7.44562  ? 197  ILE A CG1 1 
ATOM   1136 C CG2 . ILE A 1 116 ? 16.50029  -16.90080 -2.38896  1.000 7.40272  ? 197  ILE A CG2 1 
ATOM   1137 C CD1 . ILE A 1 116 ? 15.97744  -13.77380 -2.16969  1.000 8.34057  ? 197  ILE A CD1 1 
ATOM   1138 N N   . VAL A 1 117 ? 17.71150  -18.38304 0.55541   1.000 7.22392  ? 198  VAL A N   1 
ATOM   1139 C CA  . VAL A 1 117 ? 18.40879  -19.66204 0.69789   1.000 7.95566  ? 198  VAL A CA  1 
ATOM   1140 C C   . VAL A 1 117 ? 17.63044  -20.59595 1.61308   1.000 7.29263  ? 198  VAL A C   1 
ATOM   1141 O O   . VAL A 1 117 ? 17.48193  -21.78850 1.32506   1.000 8.36405  ? 198  VAL A O   1 
ATOM   1142 C CB  . VAL A 1 117 ? 19.84787  -19.42990 1.19602   1.000 8.06811  ? 198  VAL A CB  1 
ATOM   1143 C CG1 . VAL A 1 117 ? 20.50299  -20.73830 1.62449   1.000 9.09904  ? 198  VAL A CG1 1 
ATOM   1144 C CG2 . VAL A 1 117 ? 20.67179  -18.75510 0.11693   1.000 8.59141  ? 198  VAL A CG2 1 
ATOM   1145 N N   . ALA A 1 118 ? 17.09066  -20.05861 2.71282   1.000 7.31357  ? 199  ALA A N   1 
ATOM   1146 C CA  . ALA A 1 118 ? 16.36541  -20.89525 3.66502   1.000 8.30427  ? 199  ALA A CA  1 
ATOM   1147 C C   . ALA A 1 118 ? 15.10253  -21.49365 3.05603   1.000 7.69164  ? 199  ALA A C   1 
ATOM   1148 O O   . ALA A 1 118 ? 14.70180  -22.60270 3.43332   1.000 8.41775  ? 199  ALA A O   1 
ATOM   1149 C CB  . ALA A 1 118 ? 16.02028  -20.10316 4.92254   1.000 10.05838 ? 199  ALA A CB  1 
ATOM   1150 N N   . GLN A 1 119 ? 14.46070  -20.77918 2.12914   1.000 7.36129  ? 200  GLN A N   1 
ATOM   1151 C CA  . GLN A 1 119 ? 13.34062  -21.35729 1.38864   1.000 7.86895  ? 200  GLN A CA  1 
ATOM   1152 C C   . GLN A 1 119 ? 13.82338  -22.45246 0.44772   1.000 7.15038  ? 200  GLN A C   1 
ATOM   1153 O O   . GLN A 1 119 ? 13.29087  -23.56894 0.44538   1.000 7.94077  ? 200  GLN A O   1 
ATOM   1154 C CB  . GLN A 1 119 ? 12.62947  -20.26746 0.59060   1.000 7.74130  ? 200  GLN A CB  1 
ATOM   1155 C CG  . GLN A 1 119 ? 11.85084  -19.28886 1.42752   1.000 7.55016  ? 200  GLN A CG  1 
ATOM   1156 C CD  . GLN A 1 119 ? 10.52143  -19.84583 1.92530   1.000 8.25282  ? 200  GLN A CD  1 
ATOM   1157 O OE1 . GLN A 1 119 ? 10.19276  -21.01180 1.71052   1.000 8.26049  ? 200  GLN A OE1 1 
ATOM   1158 N NE2 . GLN A 1 119 ? 9.74528   -19.00057 2.59061   1.000 9.10751  ? 200  GLN A NE2 1 
ATOM   1159 N N   . ILE A 1 120 ? 14.84839  -22.14571 -0.35178  1.000 7.05215  ? 201  ILE A N   1 
ATOM   1160 C CA  . ILE A 1 120 ? 15.32554  -23.06452 -1.38024  1.000 7.80152  ? 201  ILE A CA  1 
ATOM   1161 C C   . ILE A 1 120 ? 15.81445  -24.37559 -0.76971  1.000 7.84223  ? 201  ILE A C   1 
ATOM   1162 O O   . ILE A 1 120 ? 15.58997  -25.45660 -1.33236  1.000 9.31622  ? 201  ILE A O   1 
ATOM   1163 C CB  . ILE A 1 120 ? 16.37313  -22.36082 -2.26675  1.000 7.70835  ? 201  ILE A CB  1 
ATOM   1164 C CG1 . ILE A 1 120 ? 15.69867  -21.23553 -3.06071  1.000 7.72840  ? 201  ILE A CG1 1 
ATOM   1165 C CG2 . ILE A 1 120 ? 17.07079  -23.34381 -3.18807  1.000 8.33775  ? 201  ILE A CG2 1 
ATOM   1166 C CD1 . ILE A 1 120 ? 16.65188  -20.35762 -3.84784  1.000 8.58123  ? 201  ILE A CD1 1 
ATOM   1167 N N   A GLN A 1 121 ? 16.45369  -24.27904 0.39956   0.700 8.17908  ? 202  GLN A N   1 
ATOM   1168 N N   B GLN A 1 121 ? 16.46950  -24.33194 0.39994   0.300 8.26741  ? 202  GLN A N   1 
ATOM   1169 C CA  A GLN A 1 121 ? 17.00538  -25.42610 1.10885   0.700 9.21701  ? 202  GLN A CA  1 
ATOM   1170 C CA  B GLN A 1 121 ? 16.95242  -25.59843 0.96461   0.300 9.22126  ? 202  GLN A CA  1 
ATOM   1171 C C   A GLN A 1 121 ? 15.94015  -26.46097 1.43414   0.700 7.99490  ? 202  GLN A C   1 
ATOM   1172 C C   B GLN A 1 121 ? 15.82172  -26.57733 1.25118   0.300 8.77441  ? 202  GLN A C   1 
ATOM   1173 O O   A GLN A 1 121 ? 16.25454  -27.65295 1.55870   0.700 8.30538  ? 202  GLN A O   1 
ATOM   1174 O O   B GLN A 1 121 ? 16.03697  -27.79527 1.21122   0.300 10.88675 ? 202  GLN A O   1 
ATOM   1175 C CB  A GLN A 1 121 ? 17.65497  -24.93228 2.40380   0.700 9.42862  ? 202  GLN A CB  1 
ATOM   1176 C CB  B GLN A 1 121 ? 17.79724  -25.44350 2.23595   0.300 13.16580 ? 202  GLN A CB  1 
ATOM   1177 C CG  A GLN A 1 121 ? 18.38748  -25.99771 3.21193   0.700 12.80023 ? 202  GLN A CG  1 
ATOM   1178 C CG  B GLN A 1 121 ? 18.61678  -24.20614 2.40077   0.300 14.50489 ? 202  GLN A CG  1 
ATOM   1179 C CD  A GLN A 1 121 ? 17.46479  -26.82130 4.09681   0.700 16.73894 ? 202  GLN A CD  1 
ATOM   1180 C CD  B GLN A 1 121 ? 19.36681  -24.18450 3.71457   0.300 15.25732 ? 202  GLN A CD  1 
ATOM   1181 O OE1 A GLN A 1 121 ? 16.39259  -26.36444 4.49144   0.700 20.17218 ? 202  GLN A OE1 1 
ATOM   1182 O OE1 B GLN A 1 121 ? 18.77623  -24.34789 4.78143   0.300 15.91494 ? 202  GLN A OE1 1 
ATOM   1183 N NE2 A GLN A 1 121 ? 17.87444  -28.05020 4.39922   0.700 18.45461 ? 202  GLN A NE2 1 
ATOM   1184 N NE2 B GLN A 1 121 ? 20.67962  -23.98878 3.64401   0.300 19.46134 ? 202  GLN A NE2 1 
ATOM   1185 N N   A GLN A 1 122 ? 14.68681  -26.03263 1.58892   0.700 8.05784  ? 203  GLN A N   1 
ATOM   1186 N N   B GLN A 1 122 ? 14.62323  -26.07569 1.55084   0.300 8.12092  ? 203  GLN A N   1 
ATOM   1187 C CA  A GLN A 1 122 ? 13.61999  -26.93325 1.99581   0.700 9.47852  ? 203  GLN A CA  1 
ATOM   1188 C CA  B GLN A 1 122 ? 13.52421  -26.95631 1.92666   0.300 9.22034  ? 203  GLN A CA  1 
ATOM   1189 C C   A GLN A 1 122 ? 13.03679  -27.73490 0.84672   0.700 8.62464  ? 203  GLN A C   1 
ATOM   1190 C C   B GLN A 1 122 ? 13.06202  -27.83566 0.77904   0.300 8.79804  ? 203  GLN A C   1 
ATOM   1191 O O   A GLN A 1 122 ? 12.20859  -28.61998 1.09612   0.700 10.36860 ? 203  GLN A O   1 
ATOM   1192 O O   B GLN A 1 122 ? 12.45625  -28.88452 1.02360   0.300 9.27865  ? 203  GLN A O   1 
ATOM   1193 C CB  A GLN A 1 122 ? 12.51167  -26.13993 2.68361   0.700 9.10665  ? 203  GLN A CB  1 
ATOM   1194 C CB  B GLN A 1 122 ? 12.34945  -26.12778 2.42802   0.300 9.02652  ? 203  GLN A CB  1 
ATOM   1195 C CG  A GLN A 1 122 ? 12.92788  -25.56201 4.00866   0.700 9.48224  ? 203  GLN A CG  1 
ATOM   1196 C CG  B GLN A 1 122 ? 12.64646  -25.36868 3.68979   0.300 10.92517 ? 203  GLN A CG  1 
ATOM   1197 C CD  A GLN A 1 122 ? 11.86509  -24.67835 4.61383   0.700 8.78725  ? 203  GLN A CD  1 
ATOM   1198 C CD  B GLN A 1 122 ? 11.53788  -24.41666 4.04570   0.300 10.67475 ? 203  GLN A CD  1 
ATOM   1199 O OE1 A GLN A 1 122 ? 10.83150  -25.15635 5.08751   0.700 10.49797 ? 203  GLN A OE1 1 
ATOM   1200 O OE1 B GLN A 1 122 ? 11.77673  -23.23113 4.25794   0.300 10.18596 ? 203  GLN A OE1 1 
ATOM   1201 N NE2 A GLN A 1 122 ? 12.10944  -23.37303 4.59981   0.700 9.31542  ? 203  GLN A NE2 1 
ATOM   1202 N NE2 B GLN A 1 122 ? 10.31425  -24.92567 4.11071   0.300 10.70646 ? 203  GLN A NE2 1 
ATOM   1203 N N   A PHE A 1 123 ? 13.44105  -27.45667 -0.39146  0.700 8.83765  ? 204  PHE A N   1 
ATOM   1204 N N   B PHE A 1 123 ? 13.33221  -27.44478 -0.46099  0.300 9.48529  ? 204  PHE A N   1 
ATOM   1205 C CA  A PHE A 1 123 ? 12.84518  -28.07855 -1.57562  0.700 9.47524  ? 204  PHE A CA  1 
ATOM   1206 C CA  B PHE A 1 123 ? 12.81194  -28.14721 -1.63098  0.300 9.66596  ? 204  PHE A CA  1 
ATOM   1207 C C   A PHE A 1 123 ? 13.93265  -28.54243 -2.54331  0.700 10.97802 ? 204  PHE A C   1 
ATOM   1208 C C   B PHE A 1 123 ? 13.95718  -28.53419 -2.54496  0.300 10.93053 ? 204  PHE A C   1 
ATOM   1209 O O   A PHE A 1 123 ? 14.00754  -28.08617 -3.69042  0.700 10.20031 ? 204  PHE A O   1 
ATOM   1210 O O   B PHE A 1 123 ? 14.11268  -27.99427 -3.64758  0.300 10.57997 ? 204  PHE A O   1 
ATOM   1211 C CB  A PHE A 1 123 ? 11.83970  -27.13322 -2.23541  0.700 9.94724  ? 204  PHE A CB  1 
ATOM   1212 C CB  B PHE A 1 123 ? 11.74443  -27.31257 -2.33046  0.300 9.71578  ? 204  PHE A CB  1 
ATOM   1213 C CG  A PHE A 1 123 ? 10.79457  -26.60406 -1.27668  0.700 8.57221  ? 204  PHE A CG  1 
ATOM   1214 C CG  B PHE A 1 123 ? 10.59819  -27.02162 -1.44079  0.300 10.58756 ? 204  PHE A CG  1 
ATOM   1215 C CD1 A PHE A 1 123 ? 9.66804   -27.35980 -0.97735  0.700 12.25957 ? 204  PHE A CD1 1 
ATOM   1216 C CD1 B PHE A 1 123 ? 9.61296   -27.96933 -1.24316  0.300 9.82367  ? 204  PHE A CD1 1 
ATOM   1217 C CD2 A PHE A 1 123 ? 10.94569  -25.36968 -0.66009  0.700 9.51201  ? 204  PHE A CD2 1 
ATOM   1218 C CD2 B PHE A 1 123 ? 10.54322  -25.83914 -0.72942  0.300 9.22766  ? 204  PHE A CD2 1 
ATOM   1219 C CE1 A PHE A 1 123 ? 8.71335   -26.89414 -0.09104  0.700 11.42467 ? 204  PHE A CE1 1 
ATOM   1220 C CE1 B PHE A 1 123 ? 8.56769   -27.72310 -0.38596  0.300 9.77504  ? 204  PHE A CE1 1 
ATOM   1221 C CE2 A PHE A 1 123 ? 9.98531   -24.89597 0.22670   0.700 11.58011 ? 204  PHE A CE2 1 
ATOM   1222 C CE2 B PHE A 1 123 ? 9.49637   -25.58272 0.12664   0.300 10.65932 ? 204  PHE A CE2 1 
ATOM   1223 C CZ  A PHE A 1 123 ? 8.86916   -25.66143 0.50883   0.700 12.49819 ? 204  PHE A CZ  1 
ATOM   1224 C CZ  B PHE A 1 123 ? 8.50808   -26.52591 0.30111   0.300 9.53351  ? 204  PHE A CZ  1 
ATOM   1225 N N   . PRO A 1 124 ? 14.78141  -29.48856 -2.11303  1.000 12.04789 ? 205  PRO A N   1 
ATOM   1226 C CA  . PRO A 1 124 ? 15.92321  -29.88521 -2.94256  1.000 12.73738 ? 205  PRO A CA  1 
ATOM   1227 C C   . PRO A 1 124 ? 15.53053  -30.57176 -4.23126  1.000 12.06160 ? 205  PRO A C   1 
ATOM   1228 O O   . PRO A 1 124 ? 16.36948  -30.66772 -5.13392  1.000 12.71371 ? 205  PRO A O   1 
ATOM   1229 C CB  . PRO A 1 124 ? 16.71613  -30.82973 -2.02849  1.000 14.69787 ? 205  PRO A CB  1 
ATOM   1230 C CG  . PRO A 1 124 ? 15.71652  -31.34743 -1.06963  1.000 15.48572 ? 205  PRO A CG  1 
ATOM   1231 C CD  . PRO A 1 124 ? 14.73589  -30.23972 -0.84522  1.000 12.72308 ? 205  PRO A CD  1 
ATOM   1232 N N   . ASP A 1 125 ? 14.30012  -31.05568 -4.35331  1.000 10.29142 ? 206  ASP A N   1 
ATOM   1233 C CA  A ASP A 1 125 ? 13.82712  -31.71159 -5.56605  0.633 9.88635  ? 206  ASP A CA  1 
ATOM   1234 C CA  B ASP A 1 125 ? 13.89426  -31.70718 -5.58936  0.367 9.92935  ? 206  ASP A CA  1 
ATOM   1235 C C   . ASP A 1 125 ? 13.39167  -30.73148 -6.64507  1.000 9.44034  ? 206  ASP A C   1 
ATOM   1236 O O   . ASP A 1 125 ? 12.98099  -31.16848 -7.72400  1.000 11.66384 ? 206  ASP A O   1 
ATOM   1237 C CB  A ASP A 1 125 ? 12.64773  -32.62331 -5.23175  0.633 11.94306 ? 206  ASP A CB  1 
ATOM   1238 C CB  B ASP A 1 125 ? 12.91813  -32.87493 -5.33383  0.367 10.95813 ? 206  ASP A CB  1 
ATOM   1239 C CG  A ASP A 1 125 ? 11.53673  -31.88603 -4.50875  0.633 12.41987 ? 206  ASP A CG  1 
ATOM   1240 C CG  B ASP A 1 125 ? 11.47026  -32.43296 -5.13382  0.367 12.41019 ? 206  ASP A CG  1 
ATOM   1241 O OD1 A ASP A 1 125 ? 11.84177  -31.02308 -3.65564  0.633 12.91633 ? 206  ASP A OD1 1 
ATOM   1242 O OD1 B ASP A 1 125 ? 11.21566  -31.26722 -4.76608  0.367 13.26170 ? 206  ASP A OD1 1 
ATOM   1243 O OD2 A ASP A 1 125 ? 10.35629  -32.16404 -4.79350  0.633 12.71437 ? 206  ASP A OD2 1 
ATOM   1244 O OD2 B ASP A 1 125 ? 10.57238  -33.27988 -5.34168  0.367 14.25168 ? 206  ASP A OD2 1 
ATOM   1245 N N   . VAL A 1 126 ? 13.44412  -29.42968 -6.37849  1.000 8.41465  ? 207  VAL A N   1 
ATOM   1246 C CA  . VAL A 1 126 ? 13.05223  -28.40562 -7.33522  1.000 8.06947  ? 207  VAL A CA  1 
ATOM   1247 C C   . VAL A 1 126 ? 14.31200  -27.68388 -7.78136  1.000 8.57345  ? 207  VAL A C   1 
ATOM   1248 O O   . VAL A 1 126 ? 15.09439  -27.21942 -6.94578  1.000 10.19371 ? 207  VAL A O   1 
ATOM   1249 C CB  . VAL A 1 126 ? 12.05168  -27.42269 -6.70315  1.000 8.20826  ? 207  VAL A CB  1 
ATOM   1250 C CG1 . VAL A 1 126 ? 11.70754  -26.29939 -7.66948  1.000 8.84607  ? 207  VAL A CG1 1 
ATOM   1251 C CG2 . VAL A 1 126 ? 10.78820  -28.16573 -6.25258  1.000 9.10317  ? 207  VAL A CG2 1 
ATOM   1252 N N   . ARG A 1 127 ? 14.52004  -27.59228 -9.08505  1.000 7.04289  ? 208  ARG A N   1 
ATOM   1253 C CA  . ARG A 1 127 ? 15.63312  -26.80717 -9.58881  1.000 6.97642  ? 208  ARG A CA  1 
ATOM   1254 C C   . ARG A 1 127 ? 15.24955  -25.33333 -9.62372  1.000 6.79759  ? 208  ARG A C   1 
ATOM   1255 O O   . ARG A 1 127 ? 14.11095  -24.97949 -9.95296  1.000 7.83420  ? 208  ARG A O   1 
ATOM   1256 C CB  . ARG A 1 127 ? 16.01797  -27.25757 -10.99004 1.000 8.55235  ? 208  ARG A CB  1 
ATOM   1257 C CG  . ARG A 1 127 ? 17.16981  -26.44441 -11.56359 1.000 8.66829  ? 208  ARG A CG  1 
ATOM   1258 C CD  . ARG A 1 127 ? 17.83265  -27.15485 -12.70809 1.000 9.04274  ? 208  ARG A CD  1 
ATOM   1259 N NE  . ARG A 1 127 ? 18.65088  -28.25655 -12.23416 1.000 8.27612  ? 208  ARG A NE  1 
ATOM   1260 C CZ  . ARG A 1 127 ? 19.39051  -29.00178 -13.03897 1.000 7.63815  ? 208  ARG A CZ  1 
ATOM   1261 N NH1 . ARG A 1 127 ? 19.40734  -28.78839 -14.34346 1.000 9.30072  ? 208  ARG A NH1 1 
ATOM   1262 N NH2 . ARG A 1 127 ? 20.12350  -29.98660 -12.52577 1.000 8.85787  ? 208  ARG A NH2 1 
ATOM   1263 N N   . VAL A 1 128 ? 16.20505  -24.47126 -9.29306  1.000 7.17575  ? 209  VAL A N   1 
ATOM   1264 C CA  . VAL A 1 128 ? 16.02754  -23.02800 -9.36382  1.000 6.65405  ? 209  VAL A CA  1 
ATOM   1265 C C   . VAL A 1 128 ? 17.05099  -22.46105 -10.34017 1.000 6.49460  ? 209  VAL A C   1 
ATOM   1266 O O   . VAL A 1 128 ? 18.24337  -22.79071 -10.26103 1.000 7.14498  ? 209  VAL A O   1 
ATOM   1267 C CB  . VAL A 1 128 ? 16.15613  -22.36817 -7.97749  1.000 7.45954  ? 209  VAL A CB  1 
ATOM   1268 C CG1 . VAL A 1 128 ? 15.96011  -20.86003 -8.08334  1.000 8.45496  ? 209  VAL A CG1 1 
ATOM   1269 C CG2 . VAL A 1 128 ? 15.14203  -22.96719 -7.00041  1.000 8.52224  ? 209  VAL A CG2 1 
ATOM   1270 N N   . VAL A 1 129 ? 16.58142  -21.62151 -11.26344 1.000 6.25209  ? 210  VAL A N   1 
ATOM   1271 C CA  . VAL A 1 129 ? 17.44308  -20.78801 -12.09543 1.000 6.23561  ? 210  VAL A CA  1 
ATOM   1272 C C   . VAL A 1 129 ? 17.19626  -19.34014 -11.70949 1.000 6.63962  ? 210  VAL A C   1 
ATOM   1273 O O   . VAL A 1 129 ? 16.04655  -18.88456 -11.68846 1.000 6.77123  ? 210  VAL A O   1 
ATOM   1274 C CB  . VAL A 1 129 ? 17.18547  -20.99776 -13.59613 1.000 6.60138  ? 210  VAL A CB  1 
ATOM   1275 C CG1 . VAL A 1 129 ? 18.01965  -20.00464 -14.41339 1.000 8.18176  ? 210  VAL A CG1 1 
ATOM   1276 C CG2 . VAL A 1 129 ? 17.49884  -22.42458 -13.99730 1.000 7.53195  ? 210  VAL A CG2 1 
ATOM   1277 N N   . ALA A 1 130 ? 18.26960  -18.62254 -11.39557 1.000 6.93861  ? 211  ALA A N   1 
ATOM   1278 C CA  . ALA A 1 130 ? 18.17821  -17.24131 -10.95459 1.000 6.51522  ? 211  ALA A CA  1 
ATOM   1279 C C   . ALA A 1 130 ? 18.99993  -16.32290 -11.84526 1.000 6.41599  ? 211  ALA A C   1 
ATOM   1280 O O   . ALA A 1 130 ? 20.17300  -16.59739 -12.12626 1.000 7.34892  ? 211  ALA A O   1 
ATOM   1281 C CB  . ALA A 1 130 ? 18.64589  -17.09850 -9.50856  1.000 7.66222  ? 211  ALA A CB  1 
ATOM   1282 N N   . VAL A 1 131 ? 18.39533  -15.21764 -12.25579 1.000 6.01906  ? 212  VAL A N   1 
ATOM   1283 C CA  . VAL A 1 131 ? 19.11871  -14.08514 -12.82115 1.000 6.16591  ? 212  VAL A CA  1 
ATOM   1284 C C   . VAL A 1 131 ? 19.53924  -13.19095 -11.66664 1.000 6.21430  ? 212  VAL A C   1 
ATOM   1285 O O   . VAL A 1 131 ? 18.71606  -12.82622 -10.81712 1.000 6.67961  ? 212  VAL A O   1 
ATOM   1286 C CB  . VAL A 1 131 ? 18.24641  -13.31786 -13.82626 1.000 6.83130  ? 212  VAL A CB  1 
ATOM   1287 C CG1 . VAL A 1 131 ? 18.90136  -12.00773 -14.21971 1.000 7.60822  ? 212  VAL A CG1 1 
ATOM   1288 C CG2 . VAL A 1 131 ? 17.95899  -14.17775 -15.05386 1.000 7.80820  ? 212  VAL A CG2 1 
ATOM   1289 N N   . ILE A 1 132 ? 20.82365  -12.84294 -11.61901 1.000 6.60441  ? 213  ILE A N   1 
ATOM   1290 C CA  . ILE A 1 132 ? 21.38185  -12.09822 -10.49532 1.000 6.52264  ? 213  ILE A CA  1 
ATOM   1291 C C   . ILE A 1 132 ? 21.48542  -10.61503 -10.84232 1.000 6.12129  ? 213  ILE A C   1 
ATOM   1292 O O   . ILE A 1 132 ? 22.31570  -10.19389 -11.66196 1.000 6.78140  ? 213  ILE A O   1 
ATOM   1293 C CB  . ILE A 1 132 ? 22.73684  -12.65669 -10.05047 1.000 6.99894  ? 213  ILE A CB  1 
ATOM   1294 C CG1 . ILE A 1 132 ? 22.67154  -14.17325 -9.83241  1.000 7.55905  ? 213  ILE A CG1 1 
ATOM   1295 C CG2 . ILE A 1 132 ? 23.20806  -11.93608 -8.79522  1.000 7.44188  ? 213  ILE A CG2 1 
ATOM   1296 C CD1 . ILE A 1 132 ? 21.70977  -14.61276 -8.75573  1.000 8.64307  ? 213  ILE A CD1 1 
ATOM   1297 N N   . GLU A 1 133 ? 20.64462  -9.82598  -10.18342 1.000 6.38429  ? 214  GLU A N   1 
ATOM   1298 C CA  . GLU A 1 133 ? 20.71614  -8.36988  -10.06441 1.000 6.40974  ? 214  GLU A CA  1 
ATOM   1299 C C   . GLU A 1 133 ? 20.85749  -7.60288  -11.37659 1.000 7.39512  ? 214  GLU A C   1 
ATOM   1300 O O   . GLU A 1 133 ? 21.92253  -7.04090  -11.67648 1.000 6.79926  ? 214  GLU A O   1 
ATOM   1301 C CB  . GLU A 1 133 ? 21.76771  -7.95473  -9.04200  1.000 6.32817  ? 214  GLU A CB  1 
ATOM   1302 C CG  . GLU A 1 133 ? 21.40455  -8.39603  -7.62541  1.000 6.54082  ? 214  GLU A CG  1 
ATOM   1303 C CD  . GLU A 1 133 ? 20.18619  -7.69541  -7.02552  1.000 6.10729  ? 214  GLU A CD  1 
ATOM   1304 O OE1 . GLU A 1 133 ? 19.73013  -6.65210  -7.55984  1.000 6.78543  ? 214  GLU A OE1 1 
ATOM   1305 O OE2 . GLU A 1 133 ? 19.70715  -8.16510  -5.95957  1.000 6.80035  ? 214  GLU A OE2 1 
ATOM   1306 N N   A PRO A 1 134 ? 19.80817  -7.61916  -12.20313 0.791 6.41948  ? 215  PRO A N   1 
ATOM   1307 N N   B PRO A 1 134 ? 19.76337  -7.46759  -12.12814 0.209 6.95932  ? 215  PRO A N   1 
ATOM   1308 C CA  A PRO A 1 134 ? 19.78320  -6.80766  -13.42217 0.791 6.90246  ? 215  PRO A CA  1 
ATOM   1309 C CA  B PRO A 1 134 ? 19.76458  -6.58028  -13.29695 0.209 5.59758  ? 215  PRO A CA  1 
ATOM   1310 C C   A PRO A 1 134 ? 20.32780  -5.40927  -13.23832 0.791 7.08107  ? 215  PRO A C   1 
ATOM   1311 C C   B PRO A 1 134 ? 20.21706  -5.16968  -12.94417 0.209 5.33285  ? 215  PRO A C   1 
ATOM   1312 O O   A PRO A 1 134 ? 20.01948  -4.73961  -12.25102 0.791 7.62848  ? 215  PRO A O   1 
ATOM   1313 O O   B PRO A 1 134 ? 19.90830  -4.64377  -11.87173 0.209 6.33231  ? 215  PRO A O   1 
ATOM   1314 C CB  A PRO A 1 134 ? 18.29632  -6.80122  -13.79548 0.791 7.93452  ? 215  PRO A CB  1 
ATOM   1315 C CB  B PRO A 1 134 ? 18.29994  -6.59737  -13.74577 0.209 7.43921  ? 215  PRO A CB  1 
ATOM   1316 C CG  A PRO A 1 134 ? 17.84127  -8.16706  -13.36737 0.791 7.37316  ? 215  PRO A CG  1 
ATOM   1317 C CG  B PRO A 1 134 ? 17.80901  -7.93873  -13.31854 0.209 8.11645  ? 215  PRO A CG  1 
ATOM   1318 C CD  A PRO A 1 134 ? 18.56842  -8.40737  -12.05749 0.791 6.44658  ? 215  PRO A CD  1 
ATOM   1319 C CD  B PRO A 1 134 ? 18.49843  -8.21713  -12.00888 0.209 6.59740  ? 215  PRO A CD  1 
ATOM   1320 N N   A ASP A 1 135 ? 21.17143  -5.00930  -14.19617 0.791 7.02664  ? 216  ASP A N   1 
ATOM   1321 N N   B ASP A 1 135 ? 20.96402  -4.56513  -13.87168 0.209 6.16949  ? 216  ASP A N   1 
ATOM   1322 C CA  A ASP A 1 135 ? 21.76240  -3.67777  -14.33806 0.791 7.15746  ? 216  ASP A CA  1 
ATOM   1323 C CA  B ASP A 1 135 ? 21.46094  -3.19351  -13.74433 0.209 9.01265  ? 216  ASP A CA  1 
ATOM   1324 C C   A ASP A 1 135 ? 22.98444  -3.42240  -13.46221 0.791 6.97424  ? 216  ASP A C   1 
ATOM   1325 C C   B ASP A 1 135 ? 22.31160  -3.00839  -12.49168 0.209 8.57881  ? 216  ASP A C   1 
ATOM   1326 O O   A ASP A 1 135 ? 23.79146  -2.55241  -13.79588 0.791 7.25080  ? 216  ASP A O   1 
ATOM   1327 O O   B ASP A 1 135 ? 22.17756  -2.02405  -11.76531 0.209 9.56889  ? 216  ASP A O   1 
ATOM   1328 C CB  A ASP A 1 135 ? 20.75970  -2.55225  -14.08378 0.791 8.08805  ? 216  ASP A CB  1 
ATOM   1329 C CB  B ASP A 1 135 ? 20.33484  -2.16561  -13.81829 0.209 11.16814 ? 216  ASP A CB  1 
ATOM   1330 C CG  A ASP A 1 135 ? 19.54206  -2.62595  -14.96545 0.791 8.31849  ? 216  ASP A CG  1 
ATOM   1331 C CG  B ASP A 1 135 ? 19.36189  -2.45699  -14.93174 0.209 9.62210  ? 216  ASP A CG  1 
ATOM   1332 O OD1 A ASP A 1 135 ? 19.61052  -3.18766  -16.08149 0.791 8.52362  ? 216  ASP A OD1 1 
ATOM   1333 O OD1 B ASP A 1 135 ? 19.80247  -2.63997  -16.08435 0.209 11.82749 ? 216  ASP A OD1 1 
ATOM   1334 O OD2 A ASP A 1 135 ? 18.49649  -2.09712  -14.52393 0.791 9.03380  ? 216  ASP A OD2 1 
ATOM   1335 O OD2 B ASP A 1 135 ? 18.15179  -2.53012  -14.64548 0.209 7.19639  ? 216  ASP A OD2 1 
ATOM   1336 N N   A SER A 1 136 ? 23.13081  -4.13652  -12.34367 0.791 7.44468  ? 217  SER A N   1 
ATOM   1337 N N   B SER A 1 136 ? 23.18808  -3.97432  -12.23418 0.209 6.79413  ? 217  SER A N   1 
ATOM   1338 C CA  A SER A 1 136 ? 24.11391  -3.74293  -11.33439 0.791 7.90359  ? 217  SER A CA  1 
ATOM   1339 C CA  B SER A 1 136 ? 24.14871  -3.88758  -11.14168 0.209 7.72681  ? 217  SER A CA  1 
ATOM   1340 C C   A SER A 1 136 ? 25.54408  -3.79354  -11.87238 0.791 6.64364  ? 217  SER A C   1 
ATOM   1341 C C   B SER A 1 136 ? 25.57733  -3.89466  -11.66203 0.209 7.47222  ? 217  SER A C   1 
ATOM   1342 O O   A SER A 1 136 ? 26.25867  -2.78160  -11.87501 0.791 6.93736  ? 217  SER A O   1 
ATOM   1343 O O   B SER A 1 136 ? 26.31087  -2.91779  -11.47798 0.209 9.66023  ? 217  SER A O   1 
ATOM   1344 C CB  A SER A 1 136 ? 23.95892  -4.60313  -10.08276 0.791 8.22686  ? 217  SER A CB  1 
ATOM   1345 C CB  B SER A 1 136 ? 23.93059  -5.04332  -10.15579 0.209 6.23297  ? 217  SER A CB  1 
ATOM   1346 O OG  A SER A 1 136 ? 24.15943  -5.98100  -10.34699 0.791 7.41712  ? 217  SER A OG  1 
ATOM   1347 O OG  B SER A 1 136 ? 24.38264  -6.28065  -10.68295 0.209 6.81119  ? 217  SER A OG  1 
ATOM   1348 N N   . LEU A 1 137 ? 25.98207  -4.97016  -12.32682 1.000 7.61346  ? 218  LEU A N   1 
ATOM   1349 C CA  . LEU A 1 137 ? 27.35624  -5.09757  -12.79238 1.000 8.05876  ? 218  LEU A CA  1 
ATOM   1350 C C   . LEU A 1 137 ? 27.59909  -4.25960  -14.03503 1.000 7.42217  ? 218  LEU A C   1 
ATOM   1351 O O   . LEU A 1 137 ? 28.68350  -3.69034  -14.19057 1.000 7.74053  ? 218  LEU A O   1 
ATOM   1352 C CB  . LEU A 1 137 ? 27.70650  -6.56039  -13.02948 1.000 9.29853  ? 218  LEU A CB  1 
ATOM   1353 C CG  . LEU A 1 137 ? 27.63246  -7.44793  -11.79047 1.000 10.47657 ? 218  LEU A CG  1 
ATOM   1354 C CD1 . LEU A 1 137 ? 27.99884  -8.85546  -12.17448 1.000 11.07031 ? 218  LEU A CD1 1 
ATOM   1355 C CD2 . LEU A 1 137 ? 28.52744  -6.93434  -10.66626 1.000 11.98091 ? 218  LEU A CD2 1 
ATOM   1356 N N   . ALA A 1 138 ? 26.60190  -4.15255  -14.91850 1.000 8.26063  ? 219  ALA A N   1 
ATOM   1357 C CA  . ALA A 1 138 ? 26.76911  -3.31271  -16.10075 1.000 8.12019  ? 219  ALA A CA  1 
ATOM   1358 C C   . ALA A 1 138 ? 27.02709  -1.86110  -15.71486 1.000 7.10158  ? 219  ALA A C   1 
ATOM   1359 O O   . ALA A 1 138 ? 27.86360  -1.18510  -16.33300 1.000 7.76969  ? 219  ALA A O   1 
ATOM   1360 C CB  . ALA A 1 138 ? 25.56544  -3.44764  -17.03042 1.000 8.50859  ? 219  ALA A CB  1 
ATOM   1361 N N   . ASN A 1 139 ? 26.34013  -1.37379  -14.67618 1.000 7.78695  ? 220  ASN A N   1 
ATOM   1362 C CA  . ASN A 1 139 ? 26.60944  -0.02944  -14.17023 1.000 7.63344  ? 220  ASN A CA  1 
ATOM   1363 C C   . ASN A 1 139 ? 28.03562  0.10649   -13.64063 1.000 7.49769  ? 220  ASN A C   1 
ATOM   1364 O O   . ASN A 1 139 ? 28.64798  1.17615   -13.75667 1.000 8.19119  ? 220  ASN A O   1 
ATOM   1365 C CB  . ASN A 1 139 ? 25.60239  0.34456   -13.08645 1.000 8.46368  ? 220  ASN A CB  1 
ATOM   1366 C CG  . ASN A 1 139 ? 24.29643  0.88075   -13.65462 1.000 8.40533  ? 220  ASN A CG  1 
ATOM   1367 O OD1 . ASN A 1 139 ? 24.29003  1.60252   -14.65301 1.000 9.48895  ? 220  ASN A OD1 1 
ATOM   1368 N ND2 . ASN A 1 139 ? 23.18307  0.51755   -13.03434 1.000 9.12300  ? 220  ASN A ND2 1 
ATOM   1369 N N   . LEU A 1 140 ? 28.57211  -0.95368  -13.03348 1.000 7.96682  ? 221  LEU A N   1 
ATOM   1370 C CA  . LEU A 1 140 ? 29.94710  -0.89297  -12.55234 1.000 8.24779  ? 221  LEU A CA  1 
ATOM   1371 C C   . LEU A 1 140 ? 30.95774  -0.92701  -13.68948 1.000 8.55297  ? 221  LEU A C   1 
ATOM   1372 O O   . LEU A 1 140 ? 32.13458  -0.62483  -13.45697 1.000 10.79617 ? 221  LEU A O   1 
ATOM   1373 C CB  . LEU A 1 140 ? 30.20476  -1.99359  -11.53089 1.000 8.39271  ? 221  LEU A CB  1 
ATOM   1374 C CG  . LEU A 1 140 ? 29.30269  -1.94170  -10.30010 1.000 8.84144  ? 221  LEU A CG  1 
ATOM   1375 C CD1 . LEU A 1 140 ? 29.74425  -2.98063  -9.30220  1.000 10.38079 ? 221  LEU A CD1 1 
ATOM   1376 C CD2 . LEU A 1 140 ? 29.27780  -0.55572  -9.66084  1.000 9.96930  ? 221  LEU A CD2 1 
ATOM   1377 N N   A VAL A 1 141 ? 30.57830  -1.42065  -14.86891 0.784 7.80819  ? 222  VAL A N   1 
ATOM   1378 N N   B VAL A 1 141 ? 30.49080  -1.11126  -14.92740 0.216 9.78867  ? 222  VAL A N   1 
ATOM   1379 C CA  A VAL A 1 141 ? 31.50614  -1.39080  -15.99348 0.784 8.23382  ? 222  VAL A CA  1 
ATOM   1380 C CA  B VAL A 1 141 ? 31.31967  -0.97571  -16.12243 0.216 8.46045  ? 222  VAL A CA  1 
ATOM   1381 C C   A VAL A 1 141 ? 31.60500  0.01655   -16.56716 0.784 9.33030  ? 222  VAL A C   1 
ATOM   1382 C C   B VAL A 1 141 ? 31.24484  0.43040   -16.70882 0.216 4.53462  ? 222  VAL A C   1 
ATOM   1383 O O   A VAL A 1 141 ? 32.70607  0.56065   -16.72618 0.784 10.82938 ? 222  VAL A O   1 
ATOM   1384 O O   B VAL A 1 141 ? 32.24236  1.15955   -16.72122 0.216 6.38271  ? 222  VAL A O   1 
ATOM   1385 C CB  A VAL A 1 141 ? 31.12868  -2.42373  -17.07541 0.784 7.52122  ? 222  VAL A CB  1 
ATOM   1386 C CB  B VAL A 1 141 ? 30.96182  -2.03177  -17.18321 0.216 7.10711  ? 222  VAL A CB  1 
ATOM   1387 C CG1 A VAL A 1 141 ? 32.09519  -2.32123  -18.25740 0.784 9.35224  ? 222  VAL A CG1 1 
ATOM   1388 C CG1 B VAL A 1 141 ? 31.81606  -1.83417  -18.42810 0.216 8.66092  ? 222  VAL A CG1 1 
ATOM   1389 C CG2 A VAL A 1 141 ? 31.09819  -3.83953  -16.50798 0.784 9.74077  ? 222  VAL A CG2 1 
ATOM   1390 C CG2 B VAL A 1 141 ? 31.15036  -3.42339  -16.61462 0.216 9.68138  ? 222  VAL A CG2 1 
ATOM   1391 N N   A THR A 1 142 ? 30.45572  0.63330   -16.87465 0.784 8.66008  ? 223  THR A N   1 
ATOM   1392 N N   B THR A 1 142 ? 30.08249  0.81461   -17.23191 0.216 8.88855  ? 223  THR A N   1 
ATOM   1393 C CA  A THR A 1 142 ? 30.42570  1.86229   -17.66557 0.784 8.72992  ? 223  THR A CA  1 
ATOM   1394 C CA  B THR A 1 142 ? 29.97569  2.08786   -17.93260 0.216 7.36940  ? 223  THR A CA  1 
ATOM   1395 C C   A THR A 1 142 ? 30.03854  3.13200   -16.91072 0.784 11.07477 ? 223  THR A C   1 
ATOM   1396 C C   B THR A 1 142 ? 29.60554  3.25545   -17.03596 0.216 7.27443  ? 223  THR A C   1 
ATOM   1397 O O   A THR A 1 142 ? 30.30095  4.21989   -17.42727 0.784 11.99273 ? 223  THR A O   1 
ATOM   1398 O O   B THR A 1 142 ? 29.52275  4.38697   -17.52867 0.216 6.00740  ? 223  THR A O   1 
ATOM   1399 C CB  A THR A 1 142 ? 29.47856  1.73533   -18.87533 0.784 8.90058  ? 223  THR A CB  1 
ATOM   1400 C CB  B THR A 1 142 ? 28.98234  2.00003   -19.09833 0.216 7.25744  ? 223  THR A CB  1 
ATOM   1401 O OG1 A THR A 1 142 ? 28.11634  1.79850   -18.42359 0.784 9.84148  ? 223  THR A OG1 1 
ATOM   1402 O OG1 B THR A 1 142 ? 27.64434  2.18742   -18.61159 0.216 7.64670  ? 223  THR A OG1 1 
ATOM   1403 C CG2 A THR A 1 142 ? 29.71998  0.44574   -19.64818 0.784 9.63771  ? 223  THR A CG2 1 
ATOM   1404 C CG2 B THR A 1 142 ? 29.10858  0.66873   -19.81950 0.216 7.78629  ? 223  THR A CG2 1 
ATOM   1405 N N   . ASN A 1 143 ? 29.40409  3.03807   -15.73656 1.000 10.24236 ? 224  ASN A N   1 
ATOM   1406 C CA  A ASN A 1 143 ? 28.86070  4.18168   -15.00746 0.709 9.94752  ? 224  ASN A CA  1 
ATOM   1407 C CA  B ASN A 1 143 ? 28.81835  4.12338   -14.95119 0.291 10.10588 ? 224  ASN A CA  1 
ATOM   1408 C C   . ASN A 1 143 ? 29.57247  4.47572   -13.68088 1.000 9.39394  ? 224  ASN A C   1 
ATOM   1409 O O   . ASN A 1 143 ? 28.96172  5.02084   -12.75916 1.000 9.11240  ? 224  ASN A O   1 
ATOM   1410 C CB  A ASN A 1 143 ? 27.35988  4.00770   -14.76196 0.709 10.10134 ? 224  ASN A CB  1 
ATOM   1411 C CB  B ASN A 1 143 ? 27.33257  3.93715   -14.61279 0.291 10.96090 ? 224  ASN A CB  1 
ATOM   1412 C CG  A ASN A 1 143 ? 26.50464  4.27282   -15.99278 0.709 10.62201 ? 224  ASN A CG  1 
ATOM   1413 C CG  B ASN A 1 143 ? 26.45255  3.78465   -15.82529 0.291 16.71390 ? 224  ASN A CG  1 
ATOM   1414 O OD1 A ASN A 1 143 ? 25.60101  3.49373   -16.32164 0.709 10.14918 ? 224  ASN A OD1 1 
ATOM   1415 O OD1 B ASN A 1 143 ? 26.22655  2.68290   -16.31842 0.291 17.33158 ? 224  ASN A OD1 1 
ATOM   1416 N ND2 A ASN A 1 143 ? 26.74811  5.40178   -16.64876 0.709 10.66630 ? 224  ASN A ND2 1 
ATOM   1417 N ND2 B ASN A 1 143 ? 25.89343  4.90189   -16.28096 0.291 17.33779 ? 224  ASN A ND2 1 
ATOM   1418 N N   . LEU A 1 144 ? 30.87224  4.18674   -13.58441 1.000 9.32122  ? 225  LEU A N   1 
ATOM   1419 C CA  . LEU A 1 144 ? 31.57216  4.52062   -12.34907 1.000 9.59269  ? 225  LEU A CA  1 
ATOM   1420 C C   . LEU A 1 144 ? 31.67853  6.02597   -12.12780 1.000 10.62879 ? 225  LEU A C   1 
ATOM   1421 O O   . LEU A 1 144 ? 31.93252  6.45550   -10.99701 1.000 12.02711 ? 225  LEU A O   1 
ATOM   1422 C CB  . LEU A 1 144 ? 32.94372  3.86008   -12.31253 1.000 11.67265 ? 225  LEU A CB  1 
ATOM   1423 C CG  . LEU A 1 144 ? 32.89575  2.34168   -12.13795 1.000 13.33845 ? 225  LEU A CG  1 
ATOM   1424 C CD1 . LEU A 1 144 ? 34.30264  1.76635   -12.05081 1.000 17.18294 ? 225  LEU A CD1 1 
ATOM   1425 C CD2 . LEU A 1 144 ? 32.09844  1.97871   -10.90061 1.000 15.21176 ? 225  LEU A CD2 1 
ATOM   1426 N N   . ASN A 1 145 ? 31.49218  6.83581   -13.17154 1.000 9.90468  ? 226  ASN A N   1 
ATOM   1427 C CA  A ASN A 1 145 ? 31.46783  8.27500   -12.96829 0.542 10.17828 ? 226  ASN A CA  1 
ATOM   1428 C CA  B ASN A 1 145 ? 31.44863  8.28482   -13.00837 0.458 10.18445 ? 226  ASN A CA  1 
ATOM   1429 C C   . ASN A 1 145 ? 30.14894  8.75611   -12.37755 1.000 10.99996 ? 226  ASN A C   1 
ATOM   1430 O O   . ASN A 1 145 ? 30.08783  9.89343   -11.89784 1.000 11.30030 ? 226  ASN A O   1 
ATOM   1431 C CB  A ASN A 1 145 ? 31.75430  8.99705   -14.28148 0.542 11.06793 ? 226  ASN A CB  1 
ATOM   1432 C CB  B ASN A 1 145 ? 31.62538  8.98426   -14.35679 0.458 11.55311 ? 226  ASN A CB  1 
ATOM   1433 C CG  A ASN A 1 145 ? 30.85124  8.53450   -15.39722 0.542 8.94647  ? 226  ASN A CG  1 
ATOM   1434 C CG  B ASN A 1 145 ? 33.07130  9.10044   -14.76331 0.458 9.87866  ? 226  ASN A CG  1 
ATOM   1435 O OD1 A ASN A 1 145 ? 30.67672  7.33101   -15.62248 0.542 11.58197 ? 226  ASN A OD1 1 
ATOM   1436 O OD1 B ASN A 1 145 ? 33.96389  9.08856   -13.91864 0.458 14.27428 ? 226  ASN A OD1 1 
ATOM   1437 N ND2 A ASN A 1 145 ? 30.24454  9.48743   -16.09261 0.542 11.10372 ? 226  ASN A ND2 1 
ATOM   1438 N ND2 B ASN A 1 145 ? 33.31388  9.21750   -16.06366 0.458 13.67602 ? 226  ASN A ND2 1 
ATOM   1439 N N   . VAL A 1 146 ? 29.10088  7.92959   -12.40735 1.000 10.12221 ? 227  VAL A N   1 
ATOM   1440 C CA  . VAL A 1 146 ? 27.85881  8.25726   -11.71618 1.000 9.22633  ? 227  VAL A CA  1 
ATOM   1441 C C   . VAL A 1 146 ? 28.11377  8.07489   -10.22935 1.000 9.03954  ? 227  VAL A C   1 
ATOM   1442 O O   . VAL A 1 146 ? 28.41840  6.96660   -9.77408  1.000 8.85642  ? 227  VAL A O   1 
ATOM   1443 C CB  . VAL A 1 146 ? 26.72027  7.34700   -12.19013 1.000 9.73671  ? 227  VAL A CB  1 
ATOM   1444 C CG1 . VAL A 1 146 ? 25.42575  7.70593   -11.47283 1.000 10.92915 ? 227  VAL A CG1 1 
ATOM   1445 C CG2 . VAL A 1 146 ? 26.55434  7.43658   -13.69661 1.000 10.31400 ? 227  VAL A CG2 1 
ATOM   1446 N N   . GLN A 1 147 ? 28.02755  9.16384   -9.46809  1.000 9.88623  ? 228  GLN A N   1 
ATOM   1447 C CA  . GLN A 1 147 ? 28.48471  9.09858   -8.08424  1.000 10.76490 ? 228  GLN A CA  1 
ATOM   1448 C C   . GLN A 1 147 ? 27.68501  8.09631   -7.25235  1.000 10.81252 ? 228  GLN A C   1 
ATOM   1449 O O   . GLN A 1 147 ? 28.25548  7.43057   -6.38016  1.000 10.30049 ? 228  GLN A O   1 
ATOM   1450 C CB  . GLN A 1 147 ? 28.48399  10.49529  -7.46242  1.000 14.11952 ? 228  GLN A CB  1 
ATOM   1451 C CG  . GLN A 1 147 ? 29.59960  11.41923  -7.97508  1.000 17.62461 ? 228  GLN A CG  1 
ATOM   1452 C CD  . GLN A 1 147 ? 30.93477  10.71243  -8.17889  1.000 18.77282 ? 228  GLN A CD  1 
ATOM   1453 O OE1 . GLN A 1 147 ? 31.26973  10.27544  -9.28504  1.000 22.24337 ? 228  GLN A OE1 1 
ATOM   1454 N NE2 . GLN A 1 147 ? 31.70410  10.59698  -7.10301  1.000 19.22725 ? 228  GLN A NE2 1 
ATOM   1455 N N   . LYS A 1 148 ? 26.38350  7.94546   -7.51348  1.000 10.46671 ? 229  LYS A N   1 
ATOM   1456 C CA  . LYS A 1 148 ? 25.61815  6.93656   -6.78597  1.000 9.48173  ? 229  LYS A CA  1 
ATOM   1457 C C   . LYS A 1 148 ? 26.15680  5.53762   -7.05831  1.000 9.19240  ? 229  LYS A C   1 
ATOM   1458 O O   . LYS A 1 148 ? 26.19947  4.68967   -6.15434  1.000 10.13446 ? 229  LYS A O   1 
ATOM   1459 C CB  . LYS A 1 148 ? 24.12962  7.03104   -7.13086  1.000 11.03786 ? 229  LYS A CB  1 
ATOM   1460 C CG  . LYS A 1 148 ? 23.26232  6.08014   -6.32211  1.000 12.15657 ? 229  LYS A CG  1 
ATOM   1461 C CD  . LYS A 1 148 ? 21.78822  6.25475   -6.63409  1.000 13.37425 ? 229  LYS A CD  1 
ATOM   1462 C CE  . LYS A 1 148 ? 20.93410  5.40334   -5.71538  1.000 13.93289 ? 229  LYS A CE  1 
ATOM   1463 N NZ  . LYS A 1 148 ? 19.48359  5.70949   -5.86033  1.000 17.38839 ? 229  LYS A NZ  1 
ATOM   1464 N N   . CYS A 1 149 ? 26.57120  5.27616   -8.29922  1.000 8.14039  ? 230  CYS A N   1 
ATOM   1465 C CA  . CYS A 1 149 ? 27.17123  3.98784   -8.61558  1.000 7.64068  ? 230  CYS A CA  1 
ATOM   1466 C C   . CYS A 1 149 ? 28.54741  3.84944   -7.97477  1.000 7.94057  ? 230  CYS A C   1 
ATOM   1467 O O   . CYS A 1 149 ? 28.86061  2.80889   -7.39011  1.000 8.17632  ? 230  CYS A O   1 
ATOM   1468 C CB  . CYS A 1 149 ? 27.25673  3.78919   -10.12782 1.000 7.39426  ? 230  CYS A CB  1 
ATOM   1469 S SG  . CYS A 1 149 ? 25.67085  3.76969   -10.99667 1.000 8.76948  ? 230  CYS A SG  1 
ATOM   1470 N N   . ALA A 1 150 ? 29.38832  4.88057   -8.08718  1.000 8.27773  ? 231  ALA A N   1 
ATOM   1471 C CA  . ALA A 1 150 ? 30.71440  4.82017   -7.47303  1.000 8.67317  ? 231  ALA A CA  1 
ATOM   1472 C C   . ALA A 1 150 ? 30.61169  4.55800   -5.97629  1.000 9.65127  ? 231  ALA A C   1 
ATOM   1473 O O   . ALA A 1 150 ? 31.34669  3.73220   -5.41719  1.000 10.35899 ? 231  ALA A O   1 
ATOM   1474 C CB  . ALA A 1 150 ? 31.45781  6.12980   -7.72812  1.000 10.78566 ? 231  ALA A CB  1 
ATOM   1475 N N   . ASN A 1 151 ? 29.68987  5.24381   -5.31118  1.000 9.49882  ? 232  ASN A N   1 
ATOM   1476 C CA  . ASN A 1 151 ? 29.54789  5.08303   -3.87367  1.000 9.97569  ? 232  ASN A CA  1 
ATOM   1477 C C   . ASN A 1 151 ? 28.89632  3.76204   -3.49957  1.000 8.72658  ? 232  ASN A C   1 
ATOM   1478 O O   . ASN A 1 151 ? 29.01742  3.33676   -2.34427  1.000 10.40813 ? 232  ASN A O   1 
ATOM   1479 C CB  . ASN A 1 151 ? 28.75211  6.25084   -3.29933  1.000 12.59184 ? 232  ASN A CB  1 
ATOM   1480 C CG  . ASN A 1 151 ? 29.51040  7.56129   -3.37760  1.000 18.35195 ? 232  ASN A CG  1 
ATOM   1481 O OD1 . ASN A 1 151 ? 30.74112  7.58008   -3.37678  1.000 22.35704 ? 232  ASN A OD1 1 
ATOM   1482 N ND2 . ASN A 1 151 ? 28.77699  8.66628   -3.44837  1.000 24.59325 ? 232  ASN A ND2 1 
ATOM   1483 N N   . ALA A 1 152 ? 28.21399  3.11102   -4.44209  1.000 8.47092  ? 233  ALA A N   1 
ATOM   1484 C CA  . ALA A 1 152 ? 27.61662  1.80526   -4.21832  1.000 8.91771  ? 233  ALA A CA  1 
ATOM   1485 C C   . ALA A 1 152 ? 28.51525  0.64879   -4.63655  1.000 7.52582  ? 233  ALA A C   1 
ATOM   1486 O O   . ALA A 1 152 ? 28.15913  -0.50349  -4.36123  1.000 8.27686  ? 233  ALA A O   1 
ATOM   1487 C CB  . ALA A 1 152 ? 26.27855  1.69603   -4.96005  1.000 8.38266  ? 233  ALA A CB  1 
ATOM   1488 N N   . LYS A 1 153 ? 29.67808  0.92038   -5.24757  1.000 8.80986  ? 234  LYS A N   1 
ATOM   1489 C CA  . LYS A 1 153 ? 30.45370  -0.13880  -5.88975  1.000 8.55867  ? 234  LYS A CA  1 
ATOM   1490 C C   . LYS A 1 153 ? 30.82169  -1.24609  -4.90862  1.000 7.87491  ? 234  LYS A C   1 
ATOM   1491 O O   . LYS A 1 153 ? 30.59367  -2.42823  -5.18641  1.000 8.03170  ? 234  LYS A O   1 
ATOM   1492 C CB  . LYS A 1 153 ? 31.70283  0.43207   -6.56067  1.000 9.61942  ? 234  LYS A CB  1 
ATOM   1493 C CG  . LYS A 1 153 ? 32.57924  -0.65456  -7.16683  1.000 10.05133 ? 234  LYS A CG  1 
ATOM   1494 C CD  . LYS A 1 153 ? 33.73679  -0.08484  -7.96305  1.000 12.98694 ? 234  LYS A CD  1 
ATOM   1495 C CE  . LYS A 1 153 ? 34.67772  -1.18933  -8.41481  1.000 17.30020 ? 234  LYS A CE  1 
ATOM   1496 N NZ  . LYS A 1 153 ? 35.63714  -0.73246  -9.45724  1.000 19.12572 ? 234  LYS A NZ  1 
ATOM   1497 N N   . THR A 1 154 ? 31.39742  -0.89431  -3.75485  1.000 7.88267  ? 235  THR A N   1 
ATOM   1498 C CA  . THR A 1 154 ? 31.80787  -1.95066  -2.83313  1.000 8.35200  ? 235  THR A CA  1 
ATOM   1499 C C   . THR A 1 154 ? 30.60250  -2.73171  -2.32689  1.000 7.90810  ? 235  THR A C   1 
ATOM   1500 O O   . THR A 1 154 ? 30.68166  -3.95232  -2.14189  1.000 7.79300  ? 235  THR A O   1 
ATOM   1501 C CB  . THR A 1 154 ? 32.64699  -1.41550  -1.66732  1.000 9.21663  ? 235  THR A CB  1 
ATOM   1502 O OG1 . THR A 1 154 ? 31.88980  -0.48397  -0.89216  1.000 11.51596 ? 235  THR A OG1 1 
ATOM   1503 C CG2 . THR A 1 154 ? 33.92379  -0.75440  -2.17036  1.000 12.22114 ? 235  THR A CG2 1 
ATOM   1504 N N   . THR A 1 155 ? 29.47940  -2.04328  -2.09996  1.000 7.86640  ? 236  THR A N   1 
ATOM   1505 C CA  . THR A 1 155 ? 28.27265  -2.71447  -1.62660  1.000 7.69705  ? 236  THR A CA  1 
ATOM   1506 C C   . THR A 1 155 ? 27.70211  -3.63125  -2.69776  1.000 7.03897  ? 236  THR A C   1 
ATOM   1507 O O   . THR A 1 155 ? 27.28757  -4.75877  -2.39932  1.000 7.75282  ? 236  THR A O   1 
ATOM   1508 C CB  . THR A 1 155 ? 27.22522  -1.68384  -1.20279  1.000 8.76306  ? 236  THR A CB  1 
ATOM   1509 O OG1 . THR A 1 155 ? 27.74153  -0.88685  -0.13489  1.000 10.29843 ? 236  THR A OG1 1 
ATOM   1510 C CG2 . THR A 1 155 ? 25.93861  -2.36709  -0.73610  1.000 10.22806 ? 236  THR A CG2 1 
ATOM   1511 N N   . TYR A 1 156 ? 27.66893  -3.16902  -3.94883  1.000 7.07382  ? 237  TYR A N   1 
ATOM   1512 C CA  . TYR A 1 156 ? 27.17822  -4.01413  -5.03255  1.000 7.17625  ? 237  TYR A CA  1 
ATOM   1513 C C   . TYR A 1 156 ? 28.02301  -5.27108  -5.15396  1.000 7.59010  ? 237  TYR A C   1 
ATOM   1514 O O   . TYR A 1 156 ? 27.49825  -6.38620  -5.25742  1.000 8.08865  ? 237  TYR A O   1 
ATOM   1515 C CB  . TYR A 1 156 ? 27.24163  -3.25773  -6.35389  1.000 8.51499  ? 237  TYR A CB  1 
ATOM   1516 C CG  . TYR A 1 156 ? 26.07110  -2.36186  -6.71068  1.000 7.67166  ? 237  TYR A CG  1 
ATOM   1517 C CD1 . TYR A 1 156 ? 25.16182  -1.89729  -5.75928  1.000 7.82057  ? 237  TYR A CD1 1 
ATOM   1518 C CD2 . TYR A 1 156 ? 25.90199  -1.96244  -8.02565  1.000 7.86949  ? 237  TYR A CD2 1 
ATOM   1519 C CE1 . TYR A 1 156 ? 24.10223  -1.07761  -6.13456  1.000 8.21455  ? 237  TYR A CE1 1 
ATOM   1520 C CE2 . TYR A 1 156 ? 24.86569  -1.15076  -8.40193  1.000 8.70575  ? 237  TYR A CE2 1 
ATOM   1521 C CZ  . TYR A 1 156 ? 23.97470  -0.70697  -7.46200  1.000 7.59393  ? 237  TYR A CZ  1 
ATOM   1522 O OH  . TYR A 1 156 ? 22.94789  0.10597   -7.88100  1.000 8.33943  ? 237  TYR A OH  1 
ATOM   1523 N N   . LEU A 1 157 ? 29.34751  -5.10544  -5.17331  1.000 7.52435  ? 238  LEU A N   1 
ATOM   1524 C CA  . LEU A 1 157 ? 30.21491  -6.25993  -5.36366  1.000 8.10528  ? 238  LEU A CA  1 
ATOM   1525 C C   . LEU A 1 157 ? 30.10748  -7.21791  -4.18834  1.000 7.71645  ? 238  LEU A C   1 
ATOM   1526 O O   . LEU A 1 157 ? 30.05743  -8.43928  -4.37834  1.000 8.26071  ? 238  LEU A O   1 
ATOM   1527 C CB  . LEU A 1 157 ? 31.65811  -5.81577  -5.59446  1.000 8.82482  ? 238  LEU A CB  1 
ATOM   1528 C CG  . LEU A 1 157 ? 31.88686  -5.07830  -6.91173  1.000 11.39296 ? 238  LEU A CG  1 
ATOM   1529 C CD1 . LEU A 1 157 ? 33.30297  -4.53671  -6.97262  1.000 14.15684 ? 238  LEU A CD1 1 
ATOM   1530 C CD2 . LEU A 1 157 ? 31.59522  -5.98414  -8.10178  1.000 12.81456 ? 238  LEU A CD2 1 
ATOM   1531 N N   . ALA A 1 158 ? 30.04623  -6.68523  -2.96701  1.000 7.46987  ? 239  ALA A N   1 
ATOM   1532 C CA  . ALA A 1 158 ? 29.92032  -7.54709  -1.79782  1.000 8.23591  ? 239  ALA A CA  1 
ATOM   1533 C C   . ALA A 1 158 ? 28.59515  -8.28824  -1.81445  1.000 7.27855  ? 239  ALA A C   1 
ATOM   1534 O O   . ALA A 1 158 ? 28.53403  -9.47754  -1.48846  1.000 7.59950  ? 239  ALA A O   1 
ATOM   1535 C CB  . ALA A 1 158 ? 30.02510  -6.70934  -0.52733  1.000 8.80169  ? 239  ALA A CB  1 
ATOM   1536 N N   . SER A 1 159 ? 27.52507  -7.59061  -2.18827  1.000 7.36998  ? 240  SER A N   1 
ATOM   1537 C CA  . SER A 1 159 ? 26.18936  -8.16790  -2.14325  1.000 7.58452  ? 240  SER A CA  1 
ATOM   1538 C C   . SER A 1 159 ? 26.00533  -9.21088  -3.23612  1.000 6.99814  ? 240  SER A C   1 
ATOM   1539 O O   . SER A 1 159 ? 25.47639  -10.30215 -2.98565  1.000 7.30020  ? 240  SER A O   1 
ATOM   1540 C CB  . SER A 1 159 ? 25.15819  -7.05402  -2.27579  1.000 8.23093  ? 240  SER A CB  1 
ATOM   1541 O OG  . SER A 1 159 ? 25.20620  -6.17196  -1.17305  1.000 8.62972  ? 240  SER A OG  1 
ATOM   1542 N N   . VAL A 1 160 ? 26.42105  -8.88452  -4.46275  1.000 7.43909  ? 241  VAL A N   1 
ATOM   1543 C CA  . VAL A 1 160 ? 26.39207  -9.86436  -5.54419  1.000 8.03159  ? 241  VAL A CA  1 
ATOM   1544 C C   . VAL A 1 160 ? 27.23146  -11.08111 -5.18317  1.000 7.28306  ? 241  VAL A C   1 
ATOM   1545 O O   . VAL A 1 160 ? 26.81154  -12.22966 -5.38661  1.000 7.66953  ? 241  VAL A O   1 
ATOM   1546 C CB  . VAL A 1 160 ? 26.81889  -9.22493  -6.87874  1.000 7.72881  ? 241  VAL A CB  1 
ATOM   1547 C CG1 . VAL A 1 160 ? 27.08104  -10.29417 -7.92861  1.000 8.47641  ? 241  VAL A CG1 1 
ATOM   1548 C CG2 . VAL A 1 160 ? 25.75250  -8.24537  -7.34843  1.000 8.35584  ? 241  VAL A CG2 1 
ATOM   1549 N N   . ASN A 1 161 ? 28.41821  -10.85696 -4.61848  1.000 7.72510  ? 242  ASN A N   1 
ATOM   1550 C CA  . ASN A 1 161 ? 29.24041  -11.98611 -4.21483  1.000 8.34457  ? 242  ASN A CA  1 
ATOM   1551 C C   . ASN A 1 161 ? 28.55118  -12.83690 -3.15207  1.000 7.34267  ? 242  ASN A C   1 
ATOM   1552 O O   . ASN A 1 161 ? 28.63090  -14.07109 -3.18357  1.000 8.36593  ? 242  ASN A O   1 
ATOM   1553 C CB  . ASN A 1 161 ? 30.57622  -11.49432 -3.69299  1.000 8.35337  ? 242  ASN A CB  1 
ATOM   1554 C CG  . ASN A 1 161 ? 31.44163  -12.62698 -3.26032  1.000 9.08244  ? 242  ASN A CG  1 
ATOM   1555 O OD1 . ASN A 1 161 ? 31.92223  -13.39652 -4.09414  1.000 10.52947 ? 242  ASN A OD1 1 
ATOM   1556 N ND2 . ASN A 1 161 ? 31.60677  -12.78061 -1.95575  1.000 12.13612 ? 242  ASN A ND2 1 
ATOM   1557 N N   A TYR A 1 162 ? 27.89332  -12.19912 -2.18591  0.633 7.69103  ? 243  TYR A N   1 
ATOM   1558 N N   B TYR A 1 162 ? 27.88374  -12.18825 -2.19240  0.367 7.68220  ? 243  TYR A N   1 
ATOM   1559 C CA  A TYR A 1 162 ? 27.20141  -12.97022 -1.16192  0.633 7.84115  ? 243  TYR A CA  1 
ATOM   1560 C CA  B TYR A 1 162 ? 27.16906  -12.90630 -1.13916  0.367 7.78649  ? 243  TYR A CA  1 
ATOM   1561 C C   A TYR A 1 162 ? 26.08326  -13.80356 -1.77363  0.633 7.17520  ? 243  TYR A C   1 
ATOM   1562 C C   B TYR A 1 162 ? 26.03987  -13.75247 -1.71632  0.367 7.22466  ? 243  TYR A C   1 
ATOM   1563 O O   A TYR A 1 162 ? 25.90483  -14.97967 -1.42041  0.633 7.21627  ? 243  TYR A O   1 
ATOM   1564 O O   B TYR A 1 162 ? 25.80000  -14.88132 -1.26826  0.367 7.96522  ? 243  TYR A O   1 
ATOM   1565 C CB  A TYR A 1 162 ? 26.64469  -12.04182 -0.08928  0.633 8.06248  ? 243  TYR A CB  1 
ATOM   1566 C CB  B TYR A 1 162 ? 26.61764  -11.89070 -0.13618  0.367 7.86012  ? 243  TYR A CB  1 
ATOM   1567 C CG  A TYR A 1 162 ? 26.14759  -12.79365 1.11695   0.633 7.30351  ? 243  TYR A CG  1 
ATOM   1568 C CG  B TYR A 1 162 ? 26.08973  -12.48235 1.15037   0.367 7.97509  ? 243  TYR A CG  1 
ATOM   1569 C CD1 A TYR A 1 162 ? 24.83950  -13.26719 1.18168   0.633 7.84488  ? 243  TYR A CD1 1 
ATOM   1570 C CD1 B TYR A 1 162 ? 24.78884  -12.96821 1.23705   0.367 7.44027  ? 243  TYR A CD1 1 
ATOM   1571 C CD2 A TYR A 1 162 ? 26.98493  -13.03486 2.19433   0.633 8.01251  ? 243  TYR A CD2 1 
ATOM   1572 C CD2 B TYR A 1 162 ? 26.88949  -12.55190 2.28191   0.367 7.65264  ? 243  TYR A CD2 1 
ATOM   1573 C CE1 A TYR A 1 162 ? 24.38919  -13.96416 2.28814   0.633 8.80771  ? 243  TYR A CE1 1 
ATOM   1574 C CE1 B TYR A 1 162 ? 24.30293  -13.50988 2.41663   0.367 8.10186  ? 243  TYR A CE1 1 
ATOM   1575 C CE2 A TYR A 1 162 ? 26.54689  -13.72484 3.29825   0.633 7.12132  ? 243  TYR A CE2 1 
ATOM   1576 C CE2 B TYR A 1 162 ? 26.41252  -13.09050 3.46195   0.367 7.39028  ? 243  TYR A CE2 1 
ATOM   1577 C CZ  A TYR A 1 162 ? 25.25481  -14.18530 3.34360   0.633 7.35417  ? 243  TYR A CZ  1 
ATOM   1578 C CZ  B TYR A 1 162 ? 25.12190  -13.56754 3.52638   0.367 7.71989  ? 243  TYR A CZ  1 
ATOM   1579 O OH  A TYR A 1 162 ? 24.85666  -14.86532 4.46240   0.633 8.09293  ? 243  TYR A OH  1 
ATOM   1580 O OH  B TYR A 1 162 ? 24.66328  -14.09932 4.70861   0.367 9.02077  ? 243  TYR A OH  1 
ATOM   1581 N N   . ALA A 1 163 ? 25.32682  -13.20735 -2.70163  1.000 7.07384  ? 244  ALA A N   1 
ATOM   1582 C CA  . ALA A 1 163 ? 24.26066  -13.93687 -3.37886  1.000 6.99190  ? 244  ALA A CA  1 
ATOM   1583 C C   . ALA A 1 163 ? 24.80852  -15.14569 -4.12679  1.000 6.63350  ? 244  ALA A C   1 
ATOM   1584 O O   . ALA A 1 163 ? 24.28593  -16.25937 -3.99302  1.000 6.78720  ? 244  ALA A O   1 
ATOM   1585 C CB  . ALA A 1 163 ? 23.52823  -13.00338 -4.34317  1.000 7.07053  ? 244  ALA A CB  1 
ATOM   1586 N N   . LEU A 1 164 ? 25.85751  -14.94853 -4.93593  1.000 6.99840  ? 245  LEU A N   1 
ATOM   1587 C CA  . LEU A 1 164 ? 26.41417  -16.05535 -5.70917  1.000 7.23381  ? 245  LEU A CA  1 
ATOM   1588 C C   . LEU A 1 164 ? 26.94818  -17.13805 -4.78756  1.000 7.34260  ? 245  LEU A C   1 
ATOM   1589 O O   . LEU A 1 164 ? 26.69445  -18.33036 -4.98891  1.000 7.82133  ? 245  LEU A O   1 
ATOM   1590 C CB  . LEU A 1 164 ? 27.53676  -15.53649 -6.60437  1.000 7.28035  ? 245  LEU A CB  1 
ATOM   1591 C CG  . LEU A 1 164 ? 27.14906  -14.55208 -7.70141  1.000 7.13852  ? 245  LEU A CG  1 
ATOM   1592 C CD1 . LEU A 1 164 ? 28.40605  -13.88768 -8.21639  1.000 8.25324  ? 245  LEU A CD1 1 
ATOM   1593 C CD2 . LEU A 1 164 ? 26.39744  -15.25098 -8.82300  1.000 8.26615  ? 245  LEU A CD2 1 
ATOM   1594 N N   . THR A 1 165 ? 27.69192  -16.72896 -3.76238  1.000 7.00461  ? 246  THR A N   1 
ATOM   1595 C CA  . THR A 1 165 ? 28.35953  -17.68155 -2.88665  1.000 7.59646  ? 246  THR A CA  1 
ATOM   1596 C C   . THR A 1 165 ? 27.34826  -18.52401 -2.12562  1.000 7.94879  ? 246  THR A C   1 
ATOM   1597 O O   . THR A 1 165 ? 27.51940  -19.74320 -1.97717  1.000 7.84099  ? 246  THR A O   1 
ATOM   1598 C CB  . THR A 1 165 ? 29.28668  -16.92178 -1.92184  1.000 7.89955  ? 246  THR A CB  1 
ATOM   1599 O OG1 . THR A 1 165 ? 30.37574  -16.33808 -2.65054  1.000 8.47007  ? 246  THR A OG1 1 
ATOM   1600 C CG2 . THR A 1 165 ? 29.84603  -17.83667 -0.83951  1.000 9.41267  ? 246  THR A CG2 1 
ATOM   1601 N N   . ASN A 1 166 ? 26.28017  -17.89453 -1.64227  1.000 6.75371  ? 247  ASN A N   1 
ATOM   1602 C CA  . ASN A 1 166 ? 25.34169  -18.62008 -0.80591  1.000 7.43542  ? 247  ASN A CA  1 
ATOM   1603 C C   . ASN A 1 166 ? 24.23660  -19.32224 -1.57772  1.000 6.99672  ? 247  ASN A C   1 
ATOM   1604 O O   . ASN A 1 166 ? 23.80844  -20.40636 -1.16617  1.000 7.57853  ? 247  ASN A O   1 
ATOM   1605 C CB  . ASN A 1 166 ? 24.84636  -17.71931 0.31286   1.000 8.55838  ? 247  ASN A CB  1 
ATOM   1606 C CG  . ASN A 1 166 ? 25.92740  -17.49467 1.33342   1.000 8.22857  ? 247  ASN A CG  1 
ATOM   1607 O OD1 . ASN A 1 166 ? 26.23721  -18.39737 2.10391   1.000 9.01217  ? 247  ASN A OD1 1 
ATOM   1608 N ND2 . ASN A 1 166 ? 26.57837  -16.33827 1.28497   1.000 10.06776 ? 247  ASN A ND2 1 
ATOM   1609 N N   . LEU A 1 167 ? 23.76930  -18.76062 -2.69639  1.000 6.61581  ? 248  LEU A N   1 
ATOM   1610 C CA  . LEU A 1 167 ? 22.84232  -19.50826 -3.54196  1.000 7.06679  ? 248  LEU A CA  1 
ATOM   1611 C C   . LEU A 1 167 ? 23.50071  -20.75075 -4.12858  1.000 7.08639  ? 248  LEU A C   1 
ATOM   1612 O O   . LEU A 1 167 ? 22.83469  -21.77110 -4.31674  1.000 7.31129  ? 248  LEU A O   1 
ATOM   1613 C CB  . LEU A 1 167 ? 22.24386  -18.61695 -4.63231  1.000 6.55834  ? 248  LEU A CB  1 
ATOM   1614 C CG  . LEU A 1 167 ? 21.32438  -17.50675 -4.11618  1.000 7.90058  ? 248  LEU A CG  1 
ATOM   1615 C CD1 . LEU A 1 167 ? 21.08042  -16.49070 -5.20271  1.000 8.84044  ? 248  LEU A CD1 1 
ATOM   1616 C CD2 . LEU A 1 167 ? 19.99146  -18.04610 -3.60008  1.000 9.13074  ? 248  LEU A CD2 1 
ATOM   1617 N N   . ALA A 1 168 ? 24.81356  -20.70093 -4.38693  1.000 7.22891  ? 249  ALA A N   1 
ATOM   1618 C CA  . ALA A 1 168 ? 25.50434  -21.89262 -4.86773  1.000 7.80069  ? 249  ALA A CA  1 
ATOM   1619 C C   . ALA A 1 168 ? 25.43867  -23.03442 -3.86103  1.000 7.82050  ? 249  ALA A C   1 
ATOM   1620 O O   . ALA A 1 168 ? 25.41787  -24.20572 -4.25899  1.000 8.07368  ? 249  ALA A O   1 
ATOM   1621 C CB  . ALA A 1 168 ? 26.95586  -21.56203 -5.20148  1.000 8.69362  ? 249  ALA A CB  1 
ATOM   1622 N N   . LYS A 1 169 ? 25.41360  -22.72062 -2.56149  1.000 7.36262  ? 250  LYS A N   1 
ATOM   1623 C CA  . LYS A 1 169 ? 25.38386  -23.75635 -1.53316  1.000 9.01996  ? 250  LYS A CA  1 
ATOM   1624 C C   . LYS A 1 169 ? 24.09615  -24.56876 -1.55107  1.000 8.37993  ? 250  LYS A C   1 
ATOM   1625 O O   . LYS A 1 169 ? 24.06373  -25.66678 -0.98305  1.000 10.06090 ? 250  LYS A O   1 
ATOM   1626 C CB  . LYS A 1 169 ? 25.57013  -23.13902 -0.15012  1.000 8.42778  ? 250  LYS A CB  1 
ATOM   1627 C CG  . LYS A 1 169 ? 26.92708  -22.50984 0.05075   1.000 9.09398  ? 250  LYS A CG  1 
ATOM   1628 C CD  . LYS A 1 169 ? 27.00986  -21.76601 1.36588   1.000 9.06259  ? 250  LYS A CD  1 
ATOM   1629 C CE  . LYS A 1 169 ? 28.33420  -21.03418 1.47460   1.000 10.69441 ? 250  LYS A CE  1 
ATOM   1630 N NZ  . LYS A 1 169 ? 28.39058  -20.17620 2.68369   1.000 9.21802  ? 250  LYS A NZ  1 
ATOM   1631 N N   . VAL A 1 170 ? 23.03398  -24.04382 -2.14997  1.000 8.18072  ? 251  VAL A N   1 
ATOM   1632 C CA  . VAL A 1 170 ? 21.78458  -24.77304 -2.30199  1.000 8.21897  ? 251  VAL A CA  1 
ATOM   1633 C C   . VAL A 1 170 ? 21.51611  -25.12346 -3.76306  1.000 8.53761  ? 251  VAL A C   1 
ATOM   1634 O O   . VAL A 1 170 ? 20.38333  -25.43085 -4.13412  1.000 9.95755  ? 251  VAL A O   1 
ATOM   1635 C CB  . VAL A 1 170 ? 20.60162  -24.07635 -1.60903  1.000 9.21961  ? 251  VAL A CB  1 
ATOM   1636 C CG1 . VAL A 1 170 ? 20.77127  -24.17144 -0.12040  1.000 10.91739 ? 251  VAL A CG1 1 
ATOM   1637 C CG2 . VAL A 1 170 ? 20.49688  -22.62297 -2.03757  1.000 9.89606  ? 251  VAL A CG2 1 
ATOM   1638 N N   . GLY A 1 171 ? 22.55508  -25.08604 -4.59422  1.000 8.37582  ? 252  GLY A N   1 
ATOM   1639 C CA  . GLY A 1 171 ? 22.48745  -25.66671 -5.91799  1.000 8.50809  ? 252  GLY A CA  1 
ATOM   1640 C C   . GLY A 1 171 ? 21.72918  -24.87127 -6.94869  1.000 7.19256  ? 252  GLY A C   1 
ATOM   1641 O O   . GLY A 1 171 ? 21.26905  -25.44885 -7.93980  1.000 7.52339  ? 252  GLY A O   1 
ATOM   1642 N N   . VAL A 1 172 ? 21.58986  -23.56567 -6.74917  1.000 7.14542  ? 253  VAL A N   1 
ATOM   1643 C CA  . VAL A 1 172 ? 20.88010  -22.69024 -7.67570  1.000 6.71144  ? 253  VAL A CA  1 
ATOM   1644 C C   . VAL A 1 172 ? 21.75414  -22.40892 -8.88679  1.000 6.57370  ? 253  VAL A C   1 
ATOM   1645 O O   . VAL A 1 172 ? 22.90386  -21.98225 -8.74276  1.000 7.28470  ? 253  VAL A O   1 
ATOM   1646 C CB  . VAL A 1 172 ? 20.51955  -21.37968 -6.96669  1.000 7.00524  ? 253  VAL A CB  1 
ATOM   1647 C CG1 . VAL A 1 172 ? 19.87882  -20.39938 -7.94006  1.000 7.28974  ? 253  VAL A CG1 1 
ATOM   1648 C CG2 . VAL A 1 172 ? 19.61760  -21.65504 -5.76925  1.000 8.38951  ? 253  VAL A CG2 1 
ATOM   1649 N N   . TYR A 1 173 ? 21.20220  -22.61820 -10.08218 1.000 6.30274  ? 254  TYR A N   1 
ATOM   1650 C CA  . TYR A 1 173 ? 21.90225  -22.26080 -11.30795 1.000 6.58477  ? 254  TYR A CA  1 
ATOM   1651 C C   . TYR A 1 173 ? 21.71089  -20.77632 -11.58810 1.000 6.53896  ? 254  TYR A C   1 
ATOM   1652 O O   . TYR A 1 173 ? 20.58422  -20.27164 -11.54052 1.000 7.66438  ? 254  TYR A O   1 
ATOM   1653 C CB  . TYR A 1 173 ? 21.41098  -23.12647 -12.47160 1.000 7.29103  ? 254  TYR A CB  1 
ATOM   1654 C CG  . TYR A 1 173 ? 21.98055  -24.52200 -12.36682 1.000 7.06770  ? 254  TYR A CG  1 
ATOM   1655 C CD1 . TYR A 1 173 ? 23.24686  -24.80417 -12.86575 1.000 8.38149  ? 254  TYR A CD1 1 
ATOM   1656 C CD2 . TYR A 1 173 ? 21.29015  -25.53965 -11.72012 1.000 8.01385  ? 254  TYR A CD2 1 
ATOM   1657 C CE1 . TYR A 1 173 ? 23.80500  -26.05779 -12.75084 1.000 10.49658 ? 254  TYR A CE1 1 
ATOM   1658 C CE2 . TYR A 1 173 ? 21.83944  -26.80760 -11.60232 1.000 8.78691  ? 254  TYR A CE2 1 
ATOM   1659 C CZ  . TYR A 1 173 ? 23.10018  -27.05426 -12.11722 1.000 8.77670  ? 254  TYR A CZ  1 
ATOM   1660 O OH  . TYR A 1 173 ? 23.66357  -28.30405 -12.00440 1.000 10.65278 ? 254  TYR A OH  1 
ATOM   1661 N N   . MET A 1 174 ? 22.81058  -20.06820 -11.86331 1.000 6.64123  ? 255  MET A N   1 
ATOM   1662 C CA  . MET A 1 174 ? 22.79053  -18.61233 -11.86002 1.000 6.30176  ? 255  MET A CA  1 
ATOM   1663 C C   . MET A 1 174 ? 23.36939  -18.03071 -13.13768 1.000 6.35354  ? 255  MET A C   1 
ATOM   1664 O O   . MET A 1 174 ? 24.40329  -18.48512 -13.64576 1.000 7.12294  ? 255  MET A O   1 
ATOM   1665 C CB  . MET A 1 174 ? 23.54819  -18.05460 -10.65231 1.000 7.00562  ? 255  MET A CB  1 
ATOM   1666 C CG  . MET A 1 174 ? 22.92111  -18.49486 -9.34207  1.000 7.82303  ? 255  MET A CG  1 
ATOM   1667 S SD  . MET A 1 174 ? 23.88401  -18.04039 -7.90641  1.000 8.42200  ? 255  MET A SD  1 
ATOM   1668 C CE  . MET A 1 174 ? 24.99352  -19.46138 -7.81599  1.000 8.91272  ? 255  MET A CE  1 
ATOM   1669 N N   . TYR A 1 175 ? 22.71689  -16.97705 -13.60927 1.000 6.49569  ? 256  TYR A N   1 
ATOM   1670 C CA  . TYR A 1 175 ? 23.18490  -16.14948 -14.70555 1.000 6.44284  ? 256  TYR A CA  1 
ATOM   1671 C C   . TYR A 1 175 ? 23.26072  -14.71802 -14.18601 1.000 7.03412  ? 256  TYR A C   1 
ATOM   1672 O O   . TYR A 1 175 ? 22.23758  -14.14063 -13.79572 1.000 7.42159  ? 256  TYR A O   1 
ATOM   1673 C CB  . TYR A 1 175 ? 22.23946  -16.26014 -15.90882 1.000 7.22648  ? 256  TYR A CB  1 
ATOM   1674 C CG  . TYR A 1 175 ? 22.18882  -17.65836 -16.49746 1.000 6.51842  ? 256  TYR A CG  1 
ATOM   1675 C CD1 . TYR A 1 175 ? 21.30951  -18.61286 -15.99787 1.000 7.27336  ? 256  TYR A CD1 1 
ATOM   1676 C CD2 . TYR A 1 175 ? 23.02525  -18.02993 -17.55263 1.000 7.07612  ? 256  TYR A CD2 1 
ATOM   1677 C CE1 . TYR A 1 175 ? 21.25720  -19.88782 -16.53439 1.000 7.62375  ? 256  TYR A CE1 1 
ATOM   1678 C CE2 . TYR A 1 175 ? 22.98841  -19.31321 -18.09002 1.000 7.49881  ? 256  TYR A CE2 1 
ATOM   1679 C CZ  . TYR A 1 175 ? 22.10591  -20.23905 -17.56950 1.000 7.35022  ? 256  TYR A CZ  1 
ATOM   1680 O OH  . TYR A 1 175 ? 22.03489  -21.51533 -18.07724 1.000 8.45888  ? 256  TYR A OH  1 
ATOM   1681 N N   A MET A 1 176 ? 24.47978  -14.16253 -14.14795 0.648 7.16589  ? 257  MET A N   1 
ATOM   1682 N N   B MET A 1 176 ? 24.46576  -14.15938 -14.13673 0.352 7.21653  ? 257  MET A N   1 
ATOM   1683 C CA  A MET A 1 176 ? 24.64882  -12.77414 -13.73339 0.648 7.72106  ? 257  MET A CA  1 
ATOM   1684 C CA  B MET A 1 176 ? 24.61042  -12.78948 -13.66633 0.352 7.64577  ? 257  MET A CA  1 
ATOM   1685 C C   A MET A 1 176 ? 24.11569  -11.85888 -14.81940 0.648 6.90478  ? 257  MET A C   1 
ATOM   1686 C C   B MET A 1 176 ? 24.20006  -11.82965 -14.77190 0.352 6.90269  ? 257  MET A C   1 
ATOM   1687 O O   A MET A 1 176 ? 24.37916  -12.05814 -16.00433 0.648 6.75525  ? 257  MET A O   1 
ATOM   1688 O O   B MET A 1 176 ? 24.59676  -12.00449 -15.92694 0.352 6.58935  ? 257  MET A O   1 
ATOM   1689 C CB  A MET A 1 176 ? 26.12532  -12.38773 -13.55126 0.648 8.73808  ? 257  MET A CB  1 
ATOM   1690 C CB  B MET A 1 176 ? 26.04676  -12.49647 -13.22883 0.352 7.45600  ? 257  MET A CB  1 
ATOM   1691 C CG  A MET A 1 176 ? 27.06023  -13.26442 -12.74907 0.648 12.51195 ? 257  MET A CG  1 
ATOM   1692 C CG  B MET A 1 176 ? 26.97306  -13.68889 -13.07383 0.352 14.74078 ? 257  MET A CG  1 
ATOM   1693 S SD  A MET A 1 176 ? 28.76876  -12.62819 -12.96753 0.648 11.36032 ? 257  MET A SD  1 
ATOM   1694 S SD  B MET A 1 176 ? 28.27665  -13.23612 -11.91252 0.352 11.46035 ? 257  MET A SD  1 
ATOM   1695 C CE  A MET A 1 176 ? 29.67432  -13.95170 -12.16782 0.648 16.26191 ? 257  MET A CE  1 
ATOM   1696 C CE  B MET A 1 176 ? 27.37410  -12.02755 -10.95535 0.352 18.96873 ? 257  MET A CE  1 
ATOM   1697 N N   . ASP A 1 177 ? 23.40044  -10.82179 -14.42653 1.000 7.44909  ? 258  ASP A N   1 
ATOM   1698 C CA  . ASP A 1 177 ? 22.98959  -9.85869  -15.43276 1.000 7.58240  ? 258  ASP A CA  1 
ATOM   1699 C C   . ASP A 1 177 ? 24.18758  -9.18999  -16.09210 1.000 7.06634  ? 258  ASP A C   1 
ATOM   1700 O O   . ASP A 1 177 ? 25.14123  -8.79995  -15.42129 1.000 7.82035  ? 258  ASP A O   1 
ATOM   1701 C CB  . ASP A 1 177 ? 22.08615  -8.78535  -14.88064 1.000 8.03709  ? 258  ASP A CB  1 
ATOM   1702 C CG  . ASP A 1 177 ? 21.47507  -7.99832  -15.99231 1.000 7.58979  ? 258  ASP A CG  1 
ATOM   1703 O OD1 . ASP A 1 177 ? 20.56865  -8.52438  -16.66090 1.000 10.11182 ? 258  ASP A OD1 1 
ATOM   1704 O OD2 . ASP A 1 177 ? 21.97944  -6.88180  -16.25399 1.000 8.14780  ? 258  ASP A OD2 1 
ATOM   1705 N N   . ALA A 1 178 ? 24.10086  -9.01764  -17.41077 1.000 6.95150  ? 259  ALA A N   1 
ATOM   1706 C CA  . ALA A 1 178 ? 25.19866  -8.46903  -18.19221 1.000 7.23177  ? 259  ALA A CA  1 
ATOM   1707 C C   . ALA A 1 178 ? 24.70476  -7.45292  -19.21705 1.000 6.85102  ? 259  ALA A C   1 
ATOM   1708 O O   . ALA A 1 178 ? 25.25426  -7.34191  -20.31791 1.000 8.03205  ? 259  ALA A O   1 
ATOM   1709 C CB  . ALA A 1 178 ? 26.00110  -9.57870  -18.86319 1.000 8.26819  ? 259  ALA A CB  1 
ATOM   1710 N N   . GLY A 1 179 ? 23.69957  -6.65781  -18.86492 1.000 7.12414  ? 260  GLY A N   1 
ATOM   1711 C CA  . GLY A 1 179 ? 23.29104  -5.59508  -19.77603 1.000 7.97213  ? 260  GLY A CA  1 
ATOM   1712 C C   . GLY A 1 179 ? 22.81007  -6.14316  -21.10543 1.000 6.70746  ? 260  GLY A C   1 
ATOM   1713 O O   . GLY A 1 179 ? 22.09764  -7.15362  -21.16105 1.000 7.28150  ? 260  GLY A O   1 
ATOM   1714 N N   . HIS A 1 180 ? 23.19042  -5.47390  -22.19634 1.000 7.06791  ? 261  HIS A N   1 
ATOM   1715 C CA  . HIS A 1 180 ? 22.73875  -5.84489  -23.53213 1.000 7.07345  ? 261  HIS A CA  1 
ATOM   1716 C C   . HIS A 1 180 ? 23.74191  -5.29544  -24.54214 1.000 6.91971  ? 261  HIS A C   1 
ATOM   1717 O O   . HIS A 1 180 ? 24.69788  -4.59685  -24.18034 1.000 7.16614  ? 261  HIS A O   1 
ATOM   1718 C CB  . HIS A 1 180 ? 21.30760  -5.35118  -23.79437 1.000 7.47141  ? 261  HIS A CB  1 
ATOM   1719 C CG  . HIS A 1 180 ? 21.15556  -3.86445  -23.72832 1.000 7.01984  ? 261  HIS A CG  1 
ATOM   1720 N ND1 . HIS A 1 180 ? 21.37778  -3.03705  -24.80961 1.000 7.79108  ? 261  HIS A ND1 1 
ATOM   1721 C CD2 . HIS A 1 180 ? 20.77580  -3.06631  -22.70500 1.000 8.29361  ? 261  HIS A CD2 1 
ATOM   1722 C CE1 . HIS A 1 180 ? 21.12525  -1.78928  -24.45017 1.000 7.85704  ? 261  HIS A CE1 1 
ATOM   1723 N NE2 . HIS A 1 180 ? 20.77404  -1.77891  -23.17627 1.000 8.06154  ? 261  HIS A NE2 1 
ATOM   1724 N N   . ALA A 1 181 ? 23.49998  -5.58514  -25.82457 1.000 6.72327  ? 262  ALA A N   1 
ATOM   1725 C CA  . ALA A 1 181 ? 24.45718  -5.23104  -26.87172 1.000 7.08927  ? 262  ALA A CA  1 
ATOM   1726 C C   . ALA A 1 181 ? 24.74182  -3.73592  -26.92850 1.000 7.31432  ? 262  ALA A C   1 
ATOM   1727 O O   . ALA A 1 181 ? 25.86184  -3.33407  -27.25940 1.000 8.19029  ? 262  ALA A O   1 
ATOM   1728 C CB  . ALA A 1 181 ? 23.95336  -5.71329  -28.22723 1.000 7.86189  ? 262  ALA A CB  1 
ATOM   1729 N N   . GLY A 1 182 ? 23.74644  -2.90377  -26.64244 1.000 7.95253  ? 263  GLY A N   1 
ATOM   1730 C CA  . GLY A 1 182 ? 23.90662  -1.46552  -26.68038 1.000 7.64700  ? 263  GLY A CA  1 
ATOM   1731 C C   . GLY A 1 182 ? 24.49137  -0.86837  -25.43814 1.000 6.60402  ? 263  GLY A C   1 
ATOM   1732 O O   . GLY A 1 182 ? 24.71183  0.34870   -25.36546 1.000 7.99009  ? 263  GLY A O   1 
ATOM   1733 N N   . TRP A 1 183 ? 24.76311  -1.71560  -24.44954 1.000 7.56024  ? 264  TRP A N   1 
ATOM   1734 C CA  . TRP A 1 183 ? 25.35269  -1.29018  -23.19228 1.000 7.43495  ? 264  TRP A CA  1 
ATOM   1735 C C   . TRP A 1 183 ? 26.77809  -1.82258  -23.10227 1.000 6.94617  ? 264  TRP A C   1 
ATOM   1736 O O   . TRP A 1 183 ? 27.73044  -1.04348  -23.20668 1.000 8.33263  ? 264  TRP A O   1 
ATOM   1737 C CB  . TRP A 1 183 ? 24.47733  -1.75461  -22.02641 1.000 7.48527  ? 264  TRP A CB  1 
ATOM   1738 C CG  . TRP A 1 183 ? 24.80318  -1.09239  -20.72926 1.000 7.65341  ? 264  TRP A CG  1 
ATOM   1739 C CD1 . TRP A 1 183 ? 25.90334  -0.32913  -20.44277 1.000 8.97798  ? 264  TRP A CD1 1 
ATOM   1740 C CD2 . TRP A 1 183 ? 24.02574  -1.14168  -19.52858 1.000 7.49382  ? 264  TRP A CD2 1 
ATOM   1741 N NE1 . TRP A 1 183 ? 25.84199  0.11350   -19.14212 1.000 9.14270  ? 264  TRP A NE1 1 
ATOM   1742 C CE2 . TRP A 1 183 ? 24.70649  -0.38248  -18.55714 1.000 8.92457  ? 264  TRP A CE2 1 
ATOM   1743 C CE3 . TRP A 1 183 ? 22.82686  -1.76122  -19.18049 1.000 8.21309  ? 264  TRP A CE3 1 
ATOM   1744 C CZ2 . TRP A 1 183 ? 24.21728  -0.21437  -17.26046 1.000 8.97200  ? 264  TRP A CZ2 1 
ATOM   1745 C CZ3 . TRP A 1 183 ? 22.34234  -1.59421  -17.89220 1.000 8.75123  ? 264  TRP A CZ3 1 
ATOM   1746 C CH2 . TRP A 1 183 ? 23.03442  -0.82710  -16.94955 1.000 9.81844  ? 264  TRP A CH2 1 
ATOM   1747 N N   . LEU A 1 184 ? 26.95220  -3.13855  -22.96084 1.000 7.75485  ? 265  LEU A N   1 
ATOM   1748 C CA  . LEU A 1 184 ? 28.26986  -3.74945  -22.83133 1.000 8.38783  ? 265  LEU A CA  1 
ATOM   1749 C C   . LEU A 1 184 ? 28.78363  -4.35594  -24.12812 1.000 7.32356  ? 265  LEU A C   1 
ATOM   1750 O O   . LEU A 1 184 ? 29.93944  -4.78027  -24.17840 1.000 8.44636  ? 265  LEU A O   1 
ATOM   1751 C CB  . LEU A 1 184 ? 28.26431  -4.80602  -21.72413 1.000 7.85541  ? 265  LEU A CB  1 
ATOM   1752 C CG  . LEU A 1 184 ? 27.82361  -4.31681  -20.34459 1.000 7.71445  ? 265  LEU A CG  1 
ATOM   1753 C CD1 . LEU A 1 184 ? 27.97593  -5.42555  -19.31990 1.000 8.77695  ? 265  LEU A CD1 1 
ATOM   1754 C CD2 . LEU A 1 184 ? 28.60411  -3.07545  -19.92501 1.000 8.73056  ? 265  LEU A CD2 1 
ATOM   1755 N N   . GLY A 1 185 ? 27.97312  -4.35925  -25.18935 1.000 7.88341  ? 266  GLY A N   1 
ATOM   1756 C CA  . GLY A 1 185 ? 28.37447  -4.99313  -26.43003 1.000 8.03894  ? 266  GLY A CA  1 
ATOM   1757 C C   . GLY A 1 185 ? 29.24713  -4.14613  -27.32452 1.000 7.34562  ? 266  GLY A C   1 
ATOM   1758 O O   . GLY A 1 185 ? 29.86081  -4.68407  -28.25131 1.000 9.15109  ? 266  GLY A O   1 
ATOM   1759 N N   . TRP A 1 186 ? 29.28636  -2.83303  -27.09770 1.000 8.20043  ? 267  TRP A N   1 
ATOM   1760 C CA  . TRP A 1 186 ? 30.25874  -1.99952  -27.78174 1.000 8.07197  ? 267  TRP A CA  1 
ATOM   1761 C C   . TRP A 1 186 ? 31.62102  -2.67110  -27.68506 1.000 7.92825  ? 267  TRP A C   1 
ATOM   1762 O O   . TRP A 1 186 ? 32.02966  -3.05687  -26.58235 1.000 7.77676  ? 267  TRP A O   1 
ATOM   1763 C CB  . TRP A 1 186 ? 30.35199  -0.63014  -27.10574 1.000 8.79307  ? 267  TRP A CB  1 
ATOM   1764 C CG  . TRP A 1 186 ? 29.10446  0.15555   -27.30053 1.000 7.93800  ? 267  TRP A CG  1 
ATOM   1765 C CD1 . TRP A 1 186 ? 27.98956  0.14160   -26.50411 1.000 8.80691  ? 267  TRP A CD1 1 
ATOM   1766 C CD2 . TRP A 1 186 ? 28.80620  1.03623   -28.39109 1.000 7.30636  ? 267  TRP A CD2 1 
ATOM   1767 N NE1 . TRP A 1 186 ? 27.02796  0.96822   -27.02600 1.000 9.67335  ? 267  TRP A NE1 1 
ATOM   1768 C CE2 . TRP A 1 186 ? 27.50200  1.52807   -28.18281 1.000 7.73909  ? 267  TRP A CE2 1 
ATOM   1769 C CE3 . TRP A 1 186 ? 29.52287  1.47878   -29.50761 1.000 7.79668  ? 267  TRP A CE3 1 
ATOM   1770 C CZ2 . TRP A 1 186 ? 26.89027  2.42990   -29.05346 1.000 9.42714  ? 267  TRP A CZ2 1 
ATOM   1771 C CZ3 . TRP A 1 186 ? 28.91173  2.37331   -30.37793 1.000 9.60023  ? 267  TRP A CZ3 1 
ATOM   1772 C CH2 . TRP A 1 186 ? 27.60966  2.84279   -30.14205 1.000 10.33207 ? 267  TRP A CH2 1 
ATOM   1773 N N   . PRO A 1 187 ? 32.34380  -2.84247  -28.80120 1.000 8.57339  ? 268  PRO A N   1 
ATOM   1774 C CA  . PRO A 1 187 ? 33.65402  -3.50750  -28.72850 1.000 8.01566  ? 268  PRO A CA  1 
ATOM   1775 C C   . PRO A 1 187 ? 34.52984  -2.98189  -27.61036 1.000 8.09124  ? 268  PRO A C   1 
ATOM   1776 O O   . PRO A 1 187 ? 35.18326  -3.77106  -26.91534 1.000 9.05877  ? 268  PRO A O   1 
ATOM   1777 C CB  . PRO A 1 187 ? 34.23093  -3.25874  -30.12659 1.000 9.14564  ? 268  PRO A CB  1 
ATOM   1778 C CG  . PRO A 1 187 ? 33.00359  -3.29611  -31.00077 1.000 10.48772 ? 268  PRO A CG  1 
ATOM   1779 C CD  . PRO A 1 187 ? 31.90162  -2.64013  -30.19322 1.000 8.54951  ? 268  PRO A CD  1 
ATOM   1780 N N   . ALA A 1 188 ? 34.51319  -1.66444  -27.38750 1.000 7.85220  ? 269  ALA A N   1 
ATOM   1781 C CA  . ALA A 1 188 ? 35.36417  -1.06488  -26.36832 1.000 8.00040  ? 269  ALA A CA  1 
ATOM   1782 C C   . ALA A 1 188 ? 34.99269  -1.51054  -24.96102 1.000 7.88980  ? 269  ALA A C   1 
ATOM   1783 O O   . ALA A 1 188 ? 35.83927  -1.47160  -24.06164 1.000 8.47989  ? 269  ALA A O   1 
ATOM   1784 C CB  . ALA A 1 188 ? 35.28386  0.45412   -26.46150 1.000 11.13184 ? 269  ALA A CB  1 
ATOM   1785 N N   . ASN A 1 189 ? 33.73661  -1.88919  -24.73324 1.000 7.87647  ? 270  ASN A N   1 
ATOM   1786 C CA  . ASN A 1 189 ? 33.31625  -2.28863  -23.39808 1.000 7.68784  ? 270  ASN A CA  1 
ATOM   1787 C C   . ASN A 1 189 ? 33.47096  -3.77955  -23.13197 1.000 6.96792  ? 270  ASN A C   1 
ATOM   1788 O O   . ASN A 1 189 ? 33.32565  -4.19540  -21.97576 1.000 7.86168  ? 270  ASN A O   1 
ATOM   1789 C CB  . ASN A 1 189 ? 31.84951  -1.91447  -23.16762 1.000 7.87891  ? 270  ASN A CB  1 
ATOM   1790 C CG  . ASN A 1 189 ? 31.63052  -0.41512  -23.06586 1.000 7.86956  ? 270  ASN A CG  1 
ATOM   1791 O OD1 . ASN A 1 189 ? 32.56957  0.34902   -22.81890 1.000 9.98792  ? 270  ASN A OD1 1 
ATOM   1792 N ND2 . ASN A 1 189 ? 30.38807  0.01767   -23.25272 1.000 7.78073  ? 270  ASN A ND2 1 
ATOM   1793 N N   . LEU A 1 190 ? 33.75843  -4.58608  -24.16039 1.000 7.48622  ? 271  LEU A N   1 
ATOM   1794 C CA  . LEU A 1 190 ? 33.76521  -6.03820  -23.99465 1.000 8.52516  ? 271  LEU A CA  1 
ATOM   1795 C C   . LEU A 1 190 ? 34.79586  -6.47487  -22.97044 1.000 8.40684  ? 271  LEU A C   1 
ATOM   1796 O O   . LEU A 1 190 ? 34.49706  -7.28162  -22.08014 1.000 8.38657  ? 271  LEU A O   1 
ATOM   1797 C CB  . LEU A 1 190 ? 34.04483  -6.73199  -25.32315 1.000 8.52920  ? 271  LEU A CB  1 
ATOM   1798 C CG  . LEU A 1 190 ? 33.00344  -6.59735  -26.42754 1.000 8.55057  ? 271  LEU A CG  1 
ATOM   1799 C CD1 . LEU A 1 190 ? 33.61060  -7.11388  -27.71954 1.000 9.81951  ? 271  LEU A CD1 1 
ATOM   1800 C CD2 . LEU A 1 190 ? 31.72224  -7.33948  -26.07944 1.000 10.27116 ? 271  LEU A CD2 1 
ATOM   1801 N N   . SER A 1 191 ? 36.03570  -5.98629  -23.10857 1.000 8.22378  ? 272  SER A N   1 
ATOM   1802 C CA  . SER A 1 191 ? 37.09238  -6.42069  -22.19642 1.000 8.10174  ? 272  SER A CA  1 
ATOM   1803 C C   . SER A 1 191 ? 36.89586  -5.88778  -20.78521 1.000 8.18782  ? 272  SER A C   1 
ATOM   1804 O O   . SER A 1 191 ? 37.01264  -6.67496  -19.82715 1.000 8.08722  ? 272  SER A O   1 
ATOM   1805 C CB  . SER A 1 191 ? 38.47071  -6.12014  -22.78946 1.000 9.54169  ? 272  SER A CB  1 
ATOM   1806 O OG  . SER A 1 191 ? 39.48372  -6.53280  -21.90061 1.000 10.55433 ? 272  SER A OG  1 
ATOM   1807 N N   . PRO A 1 192 ? 36.58982  -4.60364  -20.57261 1.000 7.92554  ? 273  PRO A N   1 
ATOM   1808 C CA  . PRO A 1 192 ? 36.25161  -4.16830  -19.20727 1.000 9.18052  ? 273  PRO A CA  1 
ATOM   1809 C C   . PRO A 1 192 ? 35.14526  -5.00517  -18.58404 1.000 8.46827  ? 273  PRO A C   1 
ATOM   1810 O O   . PRO A 1 192 ? 35.21551  -5.36052  -17.39724 1.000 8.35047  ? 273  PRO A O   1 
ATOM   1811 C CB  . PRO A 1 192 ? 35.84653  -2.69781  -19.39739 1.000 10.63681 ? 273  PRO A CB  1 
ATOM   1812 C CG  . PRO A 1 192 ? 36.58044  -2.26384  -20.62313 1.000 12.17928 ? 273  PRO A CG  1 
ATOM   1813 C CD  . PRO A 1 192 ? 36.64778  -3.46564  -21.51304 1.000 8.91560  ? 273  PRO A CD  1 
ATOM   1814 N N   . ALA A 1 193 ? 34.12774  -5.35324  -19.37452 1.000 7.90952  ? 274  ALA A N   1 
ATOM   1815 C CA  . ALA A 1 193 ? 33.05877  -6.20317  -18.86540 1.000 7.78377  ? 274  ALA A CA  1 
ATOM   1816 C C   . ALA A 1 193 ? 33.58283  -7.58857  -18.51263 1.000 6.90018  ? 274  ALA A C   1 
ATOM   1817 O O   . ALA A 1 193 ? 33.31631  -8.10397  -17.41837 1.000 8.04532  ? 274  ALA A O   1 
ATOM   1818 C CB  . ALA A 1 193 ? 31.93074  -6.29465  -19.89527 1.000 8.18790  ? 274  ALA A CB  1 
ATOM   1819 N N   . ALA A 1 194 ? 34.31420  -8.21639  -19.43872 1.000 7.68750  ? 275  ALA A N   1 
ATOM   1820 C CA  . ALA A 1 194 ? 34.84065  -9.54998  -19.17451 1.000 8.36548  ? 275  ALA A CA  1 
ATOM   1821 C C   . ALA A 1 194 ? 35.71377  -9.55925  -17.93017 1.000 7.65949  ? 275  ALA A C   1 
ATOM   1822 O O   . ALA A 1 194 ? 35.66416  -10.50598 -17.13399 1.000 8.60143  ? 275  ALA A O   1 
ATOM   1823 C CB  . ALA A 1 194 ? 35.61418  -10.06250 -20.38708 1.000 8.89755  ? 275  ALA A CB  1 
ATOM   1824 N N   . GLN A 1 195 ? 36.53279  -8.52200  -17.75083 1.000 8.32512  ? 276  GLN A N   1 
ATOM   1825 C CA  . GLN A 1 195 ? 37.42058  -8.48547  -16.59820 1.000 7.86404  ? 276  GLN A CA  1 
ATOM   1826 C C   . GLN A 1 195 ? 36.61748  -8.41375  -15.30136 1.000 7.98894  ? 276  GLN A C   1 
ATOM   1827 O O   . GLN A 1 195 ? 36.95003  -9.08427  -14.31987 1.000 8.59777  ? 276  GLN A O   1 
ATOM   1828 C CB  . GLN A 1 195 ? 38.35096  -7.28542  -16.73268 1.000 8.97257  ? 276  GLN A CB  1 
ATOM   1829 C CG  . GLN A 1 195 ? 39.33781  -7.44485  -17.88180 1.000 9.78223  ? 276  GLN A CG  1 
ATOM   1830 C CD  . GLN A 1 195 ? 40.24840  -6.26352  -18.02574 1.000 11.05510 ? 276  GLN A CD  1 
ATOM   1831 O OE1 . GLN A 1 195 ? 40.88522  -5.83024  -17.06045 1.000 16.37512 ? 276  GLN A OE1 1 
ATOM   1832 N NE2 . GLN A 1 195 ? 40.21053  -5.63834  -19.20303 1.000 10.78957 ? 276  GLN A NE2 1 
ATOM   1833 N N   . LEU A 1 196 ? 35.55228  -7.61009  -15.28160 1.000 8.19328  ? 277  LEU A N   1 
ATOM   1834 C CA  . LEU A 1 196 ? 34.72984  -7.52263  -14.07906 1.000 8.00849  ? 277  LEU A CA  1 
ATOM   1835 C C   . LEU A 1 196 ? 33.97753  -8.82486  -13.82163 1.000 7.62401  ? 277  LEU A C   1 
ATOM   1836 O O   . LEU A 1 196 ? 33.98418  -9.34025  -12.69586 1.000 8.02201  ? 277  LEU A O   1 
ATOM   1837 C CB  . LEU A 1 196 ? 33.77288  -6.34076  -14.16668 1.000 9.27703  ? 277  LEU A CB  1 
ATOM   1838 C CG  . LEU A 1 196 ? 32.82048  -6.23333  -12.97653 1.000 10.62699 ? 277  LEU A CG  1 
ATOM   1839 C CD1 . LEU A 1 196 ? 33.59136  -5.92328  -11.70153 1.000 17.75713 ? 277  LEU A CD1 1 
ATOM   1840 C CD2 . LEU A 1 196 ? 31.73994  -5.18875  -13.21043 1.000 13.69316 ? 277  LEU A CD2 1 
ATOM   1841 N N   A PHE A 1 197 ? 33.34155  -9.38357  -14.85686 0.738 7.47541  ? 278  PHE A N   1 
ATOM   1842 N N   B PHE A 1 197 ? 33.33266  -9.37615  -14.85354 0.262 7.55275  ? 278  PHE A N   1 
ATOM   1843 C CA  A PHE A 1 197 ? 32.62709  -10.64371 -14.67019 0.738 7.96842  ? 278  PHE A CA  1 
ATOM   1844 C CA  B PHE A 1 197 ? 32.50483  -10.56460 -14.66287 0.262 8.03548  ? 278  PHE A CA  1 
ATOM   1845 C C   A PHE A 1 197 ? 33.57020  -11.74344 -14.19567 0.738 7.26986  ? 278  PHE A C   1 
ATOM   1846 C C   B PHE A 1 197 ? 33.33739  -11.76493 -14.22307 0.262 8.35372  ? 278  PHE A C   1 
ATOM   1847 O O   A PHE A 1 197 ? 33.19483  -12.57164 -13.35241 0.738 7.30137  ? 278  PHE A O   1 
ATOM   1848 O O   B PHE A 1 197 ? 32.91778  -12.53287 -13.34773 0.262 7.44324  ? 278  PHE A O   1 
ATOM   1849 C CB  A PHE A 1 197 ? 31.94553  -11.08120 -15.96931 0.738 8.85550  ? 278  PHE A CB  1 
ATOM   1850 C CB  B PHE A 1 197 ? 31.75086  -10.88163 -15.95392 0.262 7.31045  ? 278  PHE A CB  1 
ATOM   1851 C CG  A PHE A 1 197 ? 30.87054  -10.14687 -16.45568 0.738 8.88547  ? 278  PHE A CG  1 
ATOM   1852 C CG  B PHE A 1 197 ? 30.64708  -9.90984  -16.27364 0.262 8.89825  ? 278  PHE A CG  1 
ATOM   1853 C CD1 A PHE A 1 197 ? 29.91612  -9.64044  -15.58993 0.738 10.38750 ? 278  PHE A CD1 1 
ATOM   1854 C CD1 B PHE A 1 197 ? 29.86648  -9.36387  -15.27099 0.262 13.56936 ? 278  PHE A CD1 1 
ATOM   1855 C CD2 A PHE A 1 197 ? 30.79529  -9.81159  -17.79340 0.738 7.76225  ? 278  PHE A CD2 1 
ATOM   1856 C CD2 B PHE A 1 197 ? 30.40897  -9.52505  -17.58227 0.262 10.33711 ? 278  PHE A CD2 1 
ATOM   1857 C CE1 A PHE A 1 197 ? 28.91825  -8.78532  -16.05053 0.738 11.57442 ? 278  PHE A CE1 1 
ATOM   1858 C CE1 B PHE A 1 197 ? 28.85299  -8.47054  -15.57253 0.262 14.74923 ? 278  PHE A CE1 1 
ATOM   1859 C CE2 A PHE A 1 197 ? 29.80978  -8.96469  -18.25971 0.738 9.78719  ? 278  PHE A CE2 1 
ATOM   1860 C CE2 B PHE A 1 197 ? 29.40047  -8.62740  -17.88621 0.262 8.50247  ? 278  PHE A CE2 1 
ATOM   1861 C CZ  A PHE A 1 197 ? 28.87467  -8.44601  -17.38460 0.738 10.13637 ? 278  PHE A CZ  1 
ATOM   1862 C CZ  B PHE A 1 197 ? 28.62339  -8.09968  -16.87795 0.262 13.18703 ? 278  PHE A CZ  1 
ATOM   1863 N N   A THR A 1 198 ? 34.79260  -11.77318 -14.74022 0.738 7.91573  ? 279  THR A N   1 
ATOM   1864 N N   B THR A 1 198 ? 34.51676  -11.95116 -14.82485 0.262 8.42703  ? 279  THR A N   1 
ATOM   1865 C CA  A THR A 1 198 ? 35.77872  -12.75645 -14.30692 0.738 8.27366  ? 279  THR A CA  1 
ATOM   1866 C CA  B THR A 1 198 ? 35.38587  -13.05434 -14.42137 0.262 6.51087  ? 279  THR A CA  1 
ATOM   1867 C C   A THR A 1 198 ? 36.07954  -12.59918 -12.82524 0.738 7.26546  ? 279  THR A C   1 
ATOM   1868 C C   B THR A 1 198 ? 35.90238  -12.86770 -12.99987 0.262 6.51735  ? 279  THR A C   1 
ATOM   1869 O O   A THR A 1 198 ? 36.14061  -13.58742 -12.08736 0.738 7.89708  ? 279  THR A O   1 
ATOM   1870 O O   B THR A 1 198 ? 36.06214  -13.84976 -12.26580 0.262 8.67551  ? 279  THR A O   1 
ATOM   1871 C CB  A THR A 1 198 ? 37.07694  -12.61195 -15.11153 0.738 8.42913  ? 279  THR A CB  1 
ATOM   1872 C CB  B THR A 1 198 ? 36.54814  -13.19245 -15.40762 0.262 7.11758  ? 279  THR A CB  1 
ATOM   1873 O OG1 A THR A 1 198 ? 36.83428  -12.87650 -16.49721 0.738 10.14913 ? 279  THR A OG1 1 
ATOM   1874 O OG1 B THR A 1 198 ? 36.03711  -13.48008 -16.71621 0.262 8.62064  ? 279  THR A OG1 1 
ATOM   1875 C CG2 A THR A 1 198 ? 38.12337  -13.59694 -14.60102 0.738 10.28937 ? 279  THR A CG2 1 
ATOM   1876 C CG2 B THR A 1 198 ? 37.49527  -14.30897 -14.97872 0.262 11.22027 ? 279  THR A CG2 1 
ATOM   1877 N N   A GLN A 1 199 ? 36.32519  -11.36361 -12.38253 0.738 7.40843  ? 280  GLN A N   1 
ATOM   1878 N N   B GLN A 1 199 ? 36.16714  -11.62216 -12.59758 0.262 8.35135  ? 280  GLN A N   1 
ATOM   1879 C CA  A GLN A 1 199 ? 36.63734  -11.12792 -10.97631 0.738 8.26287  ? 280  GLN A CA  1 
ATOM   1880 C CA  B GLN A 1 199 ? 36.58244  -11.34659 -11.22493 0.262 8.82356  ? 280  GLN A CA  1 
ATOM   1881 C C   A GLN A 1 199 ? 35.48921  -11.55993 -10.07851 0.738 8.14820  ? 280  GLN A C   1 
ATOM   1882 C C   B GLN A 1 199 ? 35.48814  -11.73066 -10.23550 0.262 8.29473  ? 280  GLN A C   1 
ATOM   1883 O O   A GLN A 1 199 ? 35.70992  -12.15279 -9.01225  0.738 8.45421  ? 280  GLN A O   1 
ATOM   1884 O O   B GLN A 1 199 ? 35.75068  -12.41076 -9.23438  0.262 6.92745  ? 280  GLN A O   1 
ATOM   1885 C CB  A GLN A 1 199 ? 36.96191  -9.65292  -10.74592 0.738 9.45063  ? 280  GLN A CB  1 
ATOM   1886 C CB  B GLN A 1 199 ? 36.93360  -9.86458  -11.08736 0.262 11.36655 ? 280  GLN A CB  1 
ATOM   1887 C CG  A GLN A 1 199 ? 37.54527  -9.38136  -9.37178  0.738 14.77771 ? 280  GLN A CG  1 
ATOM   1888 C CG  B GLN A 1 199 ? 38.41740  -9.57992  -11.13705 0.262 13.75270 ? 280  GLN A CG  1 
ATOM   1889 C CD  A GLN A 1 199 ? 38.81204  -10.17503 -9.11692  0.738 20.13049 ? 280  GLN A CD  1 
ATOM   1890 C CD  B GLN A 1 199 ? 39.13193  -9.98849  -9.86463  0.262 19.55803 ? 280  GLN A CD  1 
ATOM   1891 O OE1 A GLN A 1 199 ? 39.83598  -9.95923  -9.76668  0.738 21.04102 ? 280  GLN A OE1 1 
ATOM   1892 O OE1 B GLN A 1 199 ? 38.50200  -10.24243 -8.83639  0.262 18.95531 ? 280  GLN A OE1 1 
ATOM   1893 N NE2 A GLN A 1 199 ? 38.74474  -11.11110 -8.17811  0.738 14.57065 ? 280  GLN A NE2 1 
ATOM   1894 N NE2 B GLN A 1 199 ? 40.45530  -10.07020 -9.93133  0.262 20.75547 ? 280  GLN A NE2 1 
ATOM   1895 N N   . VAL A 1 200 ? 34.25391  -11.28060 -10.49958 1.000 7.46167  ? 281  VAL A N   1 
ATOM   1896 C CA  . VAL A 1 200 ? 33.08990  -11.67045 -9.70706  1.000 8.44460  ? 281  VAL A CA  1 
ATOM   1897 C C   . VAL A 1 200 ? 32.98158  -13.19181 -9.62541  1.000 6.74777  ? 281  VAL A C   1 
ATOM   1898 O O   . VAL A 1 200 ? 32.75070  -13.76441 -8.55319  1.000 7.81022  ? 281  VAL A O   1 
ATOM   1899 C CB  . VAL A 1 200 ? 31.82606  -11.02717 -10.30655 1.000 8.28311  ? 281  VAL A CB  1 
ATOM   1900 C CG1 . VAL A 1 200 ? 30.57458  -11.56615 -9.65607  1.000 9.24759  ? 281  VAL A CG1 1 
ATOM   1901 C CG2 . VAL A 1 200 ? 31.89423  -9.50831  -10.15829 1.000 9.52934  ? 281  VAL A CG2 1 
ATOM   1902 N N   . TRP A 1 201 ? 33.15519  -13.86406 -10.76308 1.000 7.30572  ? 282  TRP A N   1 
ATOM   1903 C CA  . TRP A 1 201 ? 33.13156  -15.32308 -10.80692 1.000 8.11128  ? 282  TRP A CA  1 
ATOM   1904 C C   . TRP A 1 201 ? 34.23158  -15.92326 -9.92960  1.000 8.34454  ? 282  TRP A C   1 
ATOM   1905 O O   . TRP A 1 201 ? 33.97898  -16.85775 -9.15981  1.000 8.17791  ? 282  TRP A O   1 
ATOM   1906 C CB  . TRP A 1 201 ? 33.23187  -15.73343 -12.27403 1.000 7.98164  ? 282  TRP A CB  1 
ATOM   1907 C CG  . TRP A 1 201 ? 33.47050  -17.17397 -12.62982 1.000 8.24715  ? 282  TRP A CG  1 
ATOM   1908 C CD1 . TRP A 1 201 ? 32.56828  -18.19852 -12.62278 1.000 8.70083  ? 282  TRP A CD1 1 
ATOM   1909 C CD2 . TRP A 1 201 ? 34.69010  -17.71971 -13.13747 1.000 8.86647  ? 282  TRP A CD2 1 
ATOM   1910 N NE1 . TRP A 1 201 ? 33.16135  -19.35253 -13.06951 1.000 8.48845  ? 282  TRP A NE1 1 
ATOM   1911 C CE2 . TRP A 1 201 ? 34.46498  -19.08122 -13.39534 1.000 8.40157  ? 282  TRP A CE2 1 
ATOM   1912 C CE3 . TRP A 1 201 ? 35.95780  -17.18631 -13.39305 1.000 8.28066  ? 282  TRP A CE3 1 
ATOM   1913 C CZ2 . TRP A 1 201 ? 35.45699  -19.91418 -13.90370 1.000 9.48529  ? 282  TRP A CZ2 1 
ATOM   1914 C CZ3 . TRP A 1 201 ? 36.94100  -18.01583 -13.89852 1.000 9.94716  ? 282  TRP A CZ3 1 
ATOM   1915 C CH2 . TRP A 1 201 ? 36.68777  -19.36614 -14.14156 1.000 10.23319 ? 282  TRP A CH2 1 
ATOM   1916 N N   A GLN A 1 202 ? 35.46016  -15.39088 -10.02349 0.666 8.15825  ? 283  GLN A N   1 
ATOM   1917 N N   B GLN A 1 202 ? 35.44615  -15.37157 -10.01414 0.334 8.22391  ? 283  GLN A N   1 
ATOM   1918 C CA  A GLN A 1 202 ? 36.55526  -15.85857 -9.16981  0.666 8.55552  ? 283  GLN A CA  1 
ATOM   1919 C CA  B GLN A 1 202 ? 36.55852  -15.83938 -9.19132  0.334 8.61998  ? 283  GLN A CA  1 
ATOM   1920 C C   A GLN A 1 202 ? 36.23923  -15.65583 -7.69742  0.666 7.97756  ? 283  GLN A C   1 
ATOM   1921 C C   B GLN A 1 202 ? 36.27533  -15.63756 -7.70926  0.334 8.07934  ? 283  GLN A C   1 
ATOM   1922 O O   A GLN A 1 202 ? 36.51701  -16.53054 -6.86417  0.666 8.54118  ? 283  GLN A O   1 
ATOM   1923 O O   B GLN A 1 202 ? 36.58764  -16.50514 -6.88369  0.334 8.66966  ? 283  GLN A O   1 
ATOM   1924 C CB  A GLN A 1 202 ? 37.84872  -15.10706 -9.49163  0.666 10.88377 ? 283  GLN A CB  1 
ATOM   1925 C CB  B GLN A 1 202 ? 37.81970  -15.07142 -9.58057  0.334 10.94423 ? 283  GLN A CB  1 
ATOM   1926 C CG  A GLN A 1 202 ? 38.40875  -15.32543 -10.87257 0.666 10.37444 ? 283  GLN A CG  1 
ATOM   1927 C CG  B GLN A 1 202 ? 38.76024  -15.81538 -10.50351 0.334 15.72327 ? 283  GLN A CG  1 
ATOM   1928 C CD  A GLN A 1 202 ? 39.60737  -14.43319 -11.14778 0.666 11.99630 ? 283  GLN A CD  1 
ATOM   1929 C CD  B GLN A 1 202 ? 39.66560  -14.86763 -11.26304 0.334 16.59753 ? 283  GLN A CD  1 
ATOM   1930 O OE1 A GLN A 1 202 ? 39.52633  -13.20851 -11.03908 0.666 15.44171 ? 283  GLN A OE1 1 
ATOM   1931 O OE1 B GLN A 1 202 ? 39.97570  -13.77567 -10.78567 0.334 18.48973 ? 283  GLN A OE1 1 
ATOM   1932 N NE2 A GLN A 1 202 ? 40.73063  -15.04774 -11.50699 0.666 19.36557 ? 283  GLN A NE2 1 
ATOM   1933 N NE2 B GLN A 1 202 ? 40.09337  -15.27754 -12.45118 0.334 14.60798 ? 283  GLN A NE2 1 
ATOM   1934 N N   . ASN A 1 203 ? 35.69993  -14.48840 -7.35053  1.000 8.47557  ? 284  ASN A N   1 
ATOM   1935 C CA  . ASN A 1 203 ? 35.45442  -14.19373 -5.94786  1.000 8.83660  ? 284  ASN A CA  1 
ATOM   1936 C C   . ASN A 1 203 ? 34.42761  -15.14083 -5.35455  1.000 7.56075  ? 284  ASN A C   1 
ATOM   1937 O O   . ASN A 1 203 ? 34.47699  -15.43032 -4.15332  1.000 8.72314  ? 284  ASN A O   1 
ATOM   1938 C CB  . ASN A 1 203 ? 35.01886  -12.74069 -5.77931  1.000 8.62420  ? 284  ASN A CB  1 
ATOM   1939 C CG  . ASN A 1 203 ? 36.18113  -11.78565 -5.80895  1.000 9.85407  ? 284  ASN A CG  1 
ATOM   1940 O OD1 . ASN A 1 203 ? 37.32571  -12.18478 -5.62453  1.000 11.65439 ? 284  ASN A OD1 1 
ATOM   1941 N ND2 . ASN A 1 203 ? 35.89200  -10.50550 -6.00915  1.000 13.36343 ? 284  ASN A ND2 1 
ATOM   1942 N N   . ALA A 1 204 ? 33.49833  -15.62767 -6.17671  1.000 8.25228  ? 285  ALA A N   1 
ATOM   1943 C CA  . ALA A 1 204 ? 32.49923  -16.59651 -5.76077  1.000 7.88098  ? 285  ALA A CA  1 
ATOM   1944 C C   . ALA A 1 204 ? 32.96225  -18.03551 -5.96464  1.000 8.22828  ? 285  ALA A C   1 
ATOM   1945 O O   . ALA A 1 204 ? 32.13945  -18.96250 -5.93930  1.000 10.28952 ? 285  ALA A O   1 
ATOM   1946 C CB  . ALA A 1 204 ? 31.17688  -16.33311 -6.47799  1.000 8.44224  ? 285  ALA A CB  1 
ATOM   1947 N N   . GLY A 1 205 ? 34.26432  -18.24132 -6.15674  1.000 8.41286  ? 286  GLY A N   1 
ATOM   1948 C CA  . GLY A 1 205 ? 34.83384  -19.57280 -6.18973  1.000 9.38363  ? 286  GLY A CA  1 
ATOM   1949 C C   . GLY A 1 205 ? 34.68642  -20.32990 -7.48592  1.000 8.02646  ? 286  GLY A C   1 
ATOM   1950 O O   . GLY A 1 205 ? 34.83100  -21.55689 -7.48430  1.000 9.04465  ? 286  GLY A O   1 
ATOM   1951 N N   A LYS A 1 206 ? 34.35386  -19.65106 -8.58183  0.752 8.13799  ? 287  LYS A N   1 
ATOM   1952 N N   B LYS A 1 206 ? 34.47303  -19.63714 -8.60784  0.248 8.75152  ? 287  LYS A N   1 
ATOM   1953 C CA  A LYS A 1 206 ? 34.21135  -20.30295 -9.88199  0.752 8.44462  ? 287  LYS A CA  1 
ATOM   1954 C CA  B LYS A 1 206 ? 34.19909  -20.28255 -9.89022  0.248 8.48099  ? 287  LYS A CA  1 
ATOM   1955 C C   A LYS A 1 206 ? 33.17473  -21.42028 -9.83431  0.752 7.98017  ? 287  LYS A C   1 
ATOM   1956 C C   B LYS A 1 206 ? 33.22781  -21.44903 -9.75184  0.248 7.88774  ? 287  LYS A C   1 
ATOM   1957 O O   A LYS A 1 206 ? 33.28856  -22.42224 -10.54037 0.752 8.18509  ? 287  LYS A O   1 
ATOM   1958 O O   B LYS A 1 206 ? 33.45395  -22.52459 -10.31616 0.248 10.93982 ? 287  LYS A O   1 
ATOM   1959 C CB  A LYS A 1 206 ? 35.55209  -20.80977 -10.43273 0.752 8.66281  ? 287  LYS A CB  1 
ATOM   1960 C CB  B LYS A 1 206 ? 35.47013  -20.75536 -10.61250 0.248 9.46422  ? 287  LYS A CB  1 
ATOM   1961 C CG  A LYS A 1 206 ? 36.62107  -19.72887 -10.51639 0.752 9.73565  ? 287  LYS A CG  1 
ATOM   1962 C CG  B LYS A 1 206 ? 36.74336  -19.97296 -10.37106 0.248 9.37901  ? 287  LYS A CG  1 
ATOM   1963 C CD  A LYS A 1 206 ? 37.98187  -20.30963 -10.85860 0.752 10.72085 ? 287  LYS A CD  1 
ATOM   1964 C CD  B LYS A 1 206 ? 37.95857  -20.80379 -10.79797 0.248 12.18499 ? 287  LYS A CD  1 
ATOM   1965 C CE  A LYS A 1 206 ? 39.02431  -19.21797 -11.07103 0.752 10.12267 ? 287  LYS A CE  1 
ATOM   1966 C CE  B LYS A 1 206 ? 39.00765  -19.95359 -11.50858 0.248 10.84175 ? 287  LYS A CE  1 
ATOM   1967 N NZ  A LYS A 1 206 ? 40.37021  -19.80053 -11.32869 0.752 11.16460 ? 287  LYS A NZ  1 
ATOM   1968 N NZ  B LYS A 1 206 ? 40.24168  -20.72732 -11.83784 0.248 11.63556 ? 287  LYS A NZ  1 
ATOM   1969 N N   . SER A 1 207 ? 32.14803  -21.24465 -9.00749  1.000 8.56207  ? 288  SER A N   1 
ATOM   1970 C CA  . SER A 1 207 ? 31.21414  -22.32824 -8.74936  1.000 8.19831  ? 288  SER A CA  1 
ATOM   1971 C C   . SER A 1 207 ? 30.62870  -22.85475 -10.05383 1.000 7.81657  ? 288  SER A C   1 
ATOM   1972 O O   . SER A 1 207 ? 30.22625  -22.05974 -10.91244 1.000 7.96960  ? 288  SER A O   1 
ATOM   1973 C CB  . SER A 1 207 ? 30.06011  -21.83813 -7.87803  1.000 8.78785  ? 288  SER A CB  1 
ATOM   1974 O OG  . SER A 1 207 ? 29.06257  -22.84342 -7.81235  1.000 8.74154  ? 288  SER A OG  1 
ATOM   1975 N N   . PRO A 1 208 ? 30.52172  -24.17479 -10.21623 1.000 8.10253  ? 289  PRO A N   1 
ATOM   1976 C CA  . PRO A 1 208 ? 29.86475  -24.70790 -11.41345 1.000 8.99118  ? 289  PRO A CA  1 
ATOM   1977 C C   . PRO A 1 208 ? 28.42509  -24.25521 -11.55707 1.000 7.34917  ? 289  PRO A C   1 
ATOM   1978 O O   . PRO A 1 208 ? 27.89619  -24.27938 -12.67319 1.000 9.11061  ? 289  PRO A O   1 
ATOM   1979 C CB  . PRO A 1 208 ? 29.97121  -26.22962 -11.23284 1.000 10.60190 ? 289  PRO A CB  1 
ATOM   1980 C CG  . PRO A 1 208 ? 31.12590  -26.43359 -10.29402 1.000 12.72655 ? 289  PRO A CG  1 
ATOM   1981 C CD  . PRO A 1 208 ? 31.08844  -25.24310 -9.37242  1.000 9.19574  ? 289  PRO A CD  1 
ATOM   1982 N N   . PHE A 1 209 ? 27.79104  -23.80702 -10.47516 1.000 6.71746  ? 290  PHE A N   1 
ATOM   1983 C CA  . PHE A 1 209 ? 26.42651  -23.31566 -10.54946 1.000 6.92948  ? 290  PHE A CA  1 
ATOM   1984 C C   . PHE A 1 209 ? 26.33643  -21.92976 -11.16852 1.000 7.51303  ? 290  PHE A C   1 
ATOM   1985 O O   . PHE A 1 209 ? 25.23633  -21.52105 -11.55649 1.000 8.32164  ? 290  PHE A O   1 
ATOM   1986 C CB  . PHE A 1 209 ? 25.79621  -23.32972 -9.15911  1.000 7.55482  ? 290  PHE A CB  1 
ATOM   1987 C CG  . PHE A 1 209 ? 25.66227  -24.71020 -8.59526  1.000 7.07887  ? 290  PHE A CG  1 
ATOM   1988 C CD1 . PHE A 1 209 ? 24.70907  -25.58274 -9.09269  1.000 9.50870  ? 290  PHE A CD1 1 
ATOM   1989 C CD2 . PHE A 1 209 ? 26.51017  -25.15852 -7.59323  1.000 8.41242  ? 290  PHE A CD2 1 
ATOM   1990 C CE1 . PHE A 1 209 ? 24.61322  -26.87356 -8.59869  1.000 9.32685  ? 290  PHE A CE1 1 
ATOM   1991 C CE2 . PHE A 1 209 ? 26.39820  -26.44661 -7.08368  1.000 10.79120 ? 290  PHE A CE2 1 
ATOM   1992 C CZ  . PHE A 1 209 ? 25.45656  -27.30038 -7.59272  1.000 9.89760  ? 290  PHE A CZ  1 
ATOM   1993 N N   . ILE A 1 210 ? 27.44787  -21.20019 -11.27134 1.000 7.35138  ? 291  ILE A N   1 
ATOM   1994 C CA  . ILE A 1 210 ? 27.45405  -19.89026 -11.92163 1.000 7.70287  ? 291  ILE A CA  1 
ATOM   1995 C C   . ILE A 1 210 ? 27.67565  -20.16156 -13.40685 1.000 7.69438  ? 291  ILE A C   1 
ATOM   1996 O O   . ILE A 1 210 ? 28.81030  -20.25954 -13.89014 1.000 8.31288  ? 291  ILE A O   1 
ATOM   1997 C CB  . ILE A 1 210 ? 28.50641  -18.96215 -11.33314 1.000 8.78581  ? 291  ILE A CB  1 
ATOM   1998 C CG1 . ILE A 1 210 ? 28.30292  -18.80157 -9.82941  1.000 9.69098  ? 291  ILE A CG1 1 
ATOM   1999 C CG2 . ILE A 1 210 ? 28.44130  -17.59490 -12.00203 1.000 12.06859 ? 291  ILE A CG2 1 
ATOM   2000 C CD1 . ILE A 1 210 ? 29.50583  -18.23431 -9.10941  1.000 12.03613 ? 291  ILE A CD1 1 
ATOM   2001 N N   . LYS A 1 211 ? 26.56231  -20.33453 -14.12926 1.000 8.43500  ? 292  LYS A N   1 
ATOM   2002 C CA  . LYS A 1 211 ? 26.61474  -20.78771 -15.51367 1.000 8.30398  ? 292  LYS A CA  1 
ATOM   2003 C C   . LYS A 1 211 ? 27.17690  -19.71862 -16.43438 1.000 7.59703  ? 292  LYS A C   1 
ATOM   2004 O O   . LYS A 1 211 ? 27.88170  -20.03205 -17.40134 1.000 8.70319  ? 292  LYS A O   1 
ATOM   2005 C CB  . LYS A 1 211 ? 25.21591  -21.17414 -16.00097 1.000 10.66786 ? 292  LYS A CB  1 
ATOM   2006 C CG  . LYS A 1 211 ? 24.61595  -22.41363 -15.37233 1.000 13.71194 ? 292  LYS A CG  1 
ATOM   2007 C CD  . LYS A 1 211 ? 25.41513  -23.65142 -15.72393 1.000 16.16507 ? 292  LYS A CD  1 
ATOM   2008 C CE  . LYS A 1 211 ? 25.64201  -23.77512 -17.22100 1.000 15.56161 ? 292  LYS A CE  1 
ATOM   2009 N NZ  . LYS A 1 211 ? 26.23552  -25.09846 -17.55606 1.000 20.07126 ? 292  LYS A NZ  1 
ATOM   2010 N N   . GLY A 1 212 ? 26.84618  -18.45888 -16.18125 1.000 7.61058  ? 293  GLY A N   1 
ATOM   2011 C CA  . GLY A 1 212 ? 27.21734  -17.40940 -17.09896 1.000 8.08195  ? 293  GLY A CA  1 
ATOM   2012 C C   . GLY A 1 212 ? 26.41054  -16.15754 -16.87127 1.000 6.83482  ? 293  GLY A C   1 
ATOM   2013 O O   . GLY A 1 212 ? 26.25593  -15.70801 -15.72706 1.000 6.97795  ? 293  GLY A O   1 
ATOM   2014 N N   . LEU A 1 213 ? 25.87909  -15.60544 -17.96360 1.000 6.76321  ? 294  LEU A N   1 
ATOM   2015 C CA  . LEU A 1 213 ? 25.36188  -14.24907 -17.99555 1.000 7.57637  ? 294  LEU A CA  1 
ATOM   2016 C C   . LEU A 1 213 ? 23.98178  -14.20931 -18.64315 1.000 6.39723  ? 294  LEU A C   1 
ATOM   2017 O O   . LEU A 1 213 ? 23.65582  -15.02678 -19.50629 1.000 7.48601  ? 294  LEU A O   1 
ATOM   2018 C CB  . LEU A 1 213 ? 26.30069  -13.33750 -18.79632 1.000 7.75647  ? 294  LEU A CB  1 
ATOM   2019 C CG  . LEU A 1 213 ? 27.74124  -13.23691 -18.29884 1.000 8.85122  ? 294  LEU A CG  1 
ATOM   2020 C CD1 . LEU A 1 213 ? 28.55007  -12.30438 -19.19056 1.000 9.73128  ? 294  LEU A CD1 1 
ATOM   2021 C CD2 . LEU A 1 213 ? 27.80366  -12.80557 -16.84997 1.000 10.91465 ? 294  LEU A CD2 1 
ATOM   2022 N N   . ALA A 1 214 ? 23.17456  -13.23472 -18.23026 1.000 6.83547  ? 295  ALA A N   1 
ATOM   2023 C CA  . ALA A 1 214 ? 21.87724  -12.95680 -18.83971 1.000 6.22576  ? 295  ALA A CA  1 
ATOM   2024 C C   . ALA A 1 214 ? 21.97382  -11.62210 -19.57066 1.000 6.49248  ? 295  ALA A C   1 
ATOM   2025 O O   . ALA A 1 214 ? 22.62537  -10.68215 -19.08638 1.000 7.68377  ? 295  ALA A O   1 
ATOM   2026 C CB  . ALA A 1 214 ? 20.78365  -12.87155 -17.76925 1.000 7.54006  ? 295  ALA A CB  1 
ATOM   2027 N N   . THR A 1 215 ? 21.36355  -11.53948 -20.75383 1.000 6.64401  ? 296  THR A N   1 
ATOM   2028 C CA  . THR A 1 215 ? 21.40608  -10.31146 -21.53237 1.000 6.86230  ? 296  THR A CA  1 
ATOM   2029 C C   . THR A 1 215 ? 20.00651  -9.89393  -21.96965 1.000 6.33477  ? 296  THR A C   1 
ATOM   2030 O O   . THR A 1 215 ? 19.06489  -10.69501 -22.03689 1.000 7.29443  ? 296  THR A O   1 
ATOM   2031 C CB  . THR A 1 215 ? 22.35055  -10.36853 -22.75939 1.000 7.48662  ? 296  THR A CB  1 
ATOM   2032 O OG1 . THR A 1 215 ? 21.69263  -11.01728 -23.86101 1.000 7.53157  ? 296  THR A OG1 1 
ATOM   2033 C CG2 . THR A 1 215 ? 23.65346  -11.07459 -22.43003 1.000 8.63583  ? 296  THR A CG2 1 
ATOM   2034 N N   . ASN A 1 216 ? 19.89666  -8.59934  -22.27366 1.000 6.78371  ? 297  ASN A N   1 
ATOM   2035 C CA  . ASN A 1 216 ? 18.68832  -7.96954  -22.79455 1.000 6.90321  ? 297  ASN A CA  1 
ATOM   2036 C C   . ASN A 1 216 ? 17.53707  -7.92936  -21.79181 1.000 6.75928  ? 297  ASN A C   1 
ATOM   2037 O O   . ASN A 1 216 ? 16.38938  -7.71572  -22.19294 1.000 6.77680  ? 297  ASN A O   1 
ATOM   2038 C CB  . ASN A 1 216 ? 18.24046  -8.57165  -24.13421 1.000 6.82146  ? 297  ASN A CB  1 
ATOM   2039 C CG  . ASN A 1 216 ? 17.37317  -7.62979  -24.93469 1.000 7.03474  ? 297  ASN A CG  1 
ATOM   2040 O OD1 . ASN A 1 216 ? 17.71877  -6.46495  -25.14878 1.000 7.40569  ? 297  ASN A OD1 1 
ATOM   2041 N ND2 . ASN A 1 216 ? 16.23531  -8.13405  -25.39680 1.000 7.72277  ? 297  ASN A ND2 1 
ATOM   2042 N N   A VAL A 1 217 ? 17.81775  -8.15486  -20.50061 0.876 6.91419  ? 298  VAL A N   1 
ATOM   2043 N N   B VAL A 1 217 ? 17.80882  -8.07969  -20.49275 0.124 6.89358  ? 298  VAL A N   1 
ATOM   2044 C CA  A VAL A 1 217 ? 16.75180  -8.20085  -19.50626 0.876 6.71260  ? 298  VAL A CA  1 
ATOM   2045 C CA  B VAL A 1 217 ? 16.73629  -8.01520  -19.50398 0.124 6.99374  ? 298  VAL A CA  1 
ATOM   2046 C C   A VAL A 1 217 ? 16.05801  -6.85343  -19.44963 0.876 6.90257  ? 298  VAL A C   1 
ATOM   2047 C C   B VAL A 1 217 ? 16.05697  -6.65470  -19.56554 0.124 7.67972  ? 298  VAL A C   1 
ATOM   2048 O O   A VAL A 1 217 ? 16.69396  -5.80618  -19.25663 0.876 7.14343  ? 298  VAL A O   1 
ATOM   2049 O O   B VAL A 1 217 ? 16.71978  -5.60947  -19.57258 0.124 8.88982  ? 298  VAL A O   1 
ATOM   2050 C CB  A VAL A 1 217 ? 17.30291  -8.58617  -18.12780 0.876 6.63760  ? 298  VAL A CB  1 
ATOM   2051 C CB  B VAL A 1 217 ? 17.27895  -8.31129  -18.09820 0.124 6.81299  ? 298  VAL A CB  1 
ATOM   2052 C CG1 A VAL A 1 217 ? 16.21277  -8.43846  -17.07143 0.876 7.25358  ? 298  VAL A CG1 1 
ATOM   2053 C CG1 B VAL A 1 217 ? 16.20075  -8.06434  -17.04869 0.124 6.89918  ? 298  VAL A CG1 1 
ATOM   2054 C CG2 A VAL A 1 217 ? 17.86107  -9.99522  -18.15273 0.876 7.70294  ? 298  VAL A CG2 1 
ATOM   2055 C CG2 B VAL A 1 217 ? 17.79373  -9.73830  -18.01835 0.124 6.97290  ? 298  VAL A CG2 1 
ATOM   2056 N N   A ALA A 1 218 ? 14.73612  -6.87297  -19.61455 0.876 6.92787  ? 299  ALA A N   1 
ATOM   2057 N N   B ALA A 1 218 ? 14.72318  -6.66890  -19.63908 0.124 7.20131  ? 299  ALA A N   1 
ATOM   2058 C CA  A ALA A 1 218 ? 13.93155  -5.66249  -19.61336 0.876 7.85652  ? 299  ALA A CA  1 
ATOM   2059 C CA  B ALA A 1 218 ? 13.89147  -5.46792  -19.60655 0.124 8.11475  ? 299  ALA A CA  1 
ATOM   2060 C C   A ALA A 1 218 ? 14.28362  -4.73102  -20.76278 0.876 7.14511  ? 299  ALA A C   1 
ATOM   2061 C C   B ALA A 1 218 ? 13.97160  -4.62628  -20.87759 0.124 8.90952  ? 299  ALA A C   1 
ATOM   2062 O O   A ALA A 1 218 ? 13.91738  -3.54963  -20.73594 0.876 8.76985  ? 299  ALA A O   1 
ATOM   2063 O O   B ALA A 1 218 ? 13.20451  -3.67277  -21.03425 0.124 5.74526  ? 299  ALA A O   1 
ATOM   2064 C CB  A ALA A 1 218 ? 13.96587  -4.93260  -18.26306 0.876 7.68780  ? 299  ALA A CB  1 
ATOM   2065 C CB  B ALA A 1 218 ? 14.16983  -4.61951  -18.35858 0.124 8.78274  ? 299  ALA A CB  1 
ATOM   2066 N N   A ASN A 1 219 ? 14.95256  -5.23802  -21.79537 0.876 6.86300  ? 300  ASN A N   1 
ATOM   2067 N N   B ASN A 1 219 ? 14.86850  -4.96069  -21.79520 0.124 7.05968  ? 300  ASN A N   1 
ATOM   2068 C CA  A ASN A 1 219 ? 15.23424  -4.43121  -22.96789 0.876 6.97662  ? 300  ASN A CA  1 
ATOM   2069 C CA  B ASN A 1 219 ? 15.01862  -4.16249  -23.00022 0.124 7.56222  ? 300  ASN A CA  1 
ATOM   2070 C C   A ASN A 1 219 ? 14.52927  -5.02880  -24.19193 0.876 6.18514  ? 300  ASN A C   1 
ATOM   2071 C C   B ASN A 1 219 ? 14.26236  -4.79400  -24.17355 0.124 7.38518  ? 300  ASN A C   1 
ATOM   2072 O O   A ASN A 1 219 ? 13.67407  -5.91398  -24.07081 0.876 7.13844  ? 300  ASN A O   1 
ATOM   2073 O O   B ASN A 1 219 ? 13.28987  -5.53235  -23.98099 0.124 6.56958  ? 300  ASN A O   1 
ATOM   2074 C CB  A ASN A 1 219 ? 16.73797  -4.14674  -23.11467 0.876 6.82198  ? 300  ASN A CB  1 
ATOM   2075 C CB  B ASN A 1 219 ? 16.49933  -3.90319  -23.29284 0.124 7.84692  ? 300  ASN A CB  1 
ATOM   2076 C CG  A ASN A 1 219 ? 17.01084  -2.79611  -23.77310 0.876 6.68090  ? 300  ASN A CG  1 
ATOM   2077 C CG  B ASN A 1 219 ? 16.75504  -2.47546  -23.72718 0.124 7.48985  ? 300  ASN A CG  1 
ATOM   2078 O OD1 A ASN A 1 219 ? 16.75730  -2.61548  -24.96969 0.876 8.23845  ? 300  ASN A OD1 1 
ATOM   2079 O OD1 B ASN A 1 219 ? 16.58704  -2.14184  -24.89834 0.124 6.12428  ? 300  ASN A OD1 1 
ATOM   2080 N ND2 A ASN A 1 219 ? 17.50642  -1.83536  -22.99670 0.876 7.72033  ? 300  ASN A ND2 1 
ATOM   2081 N ND2 B ASN A 1 219 ? 17.17752  -1.62868  -22.79441 0.124 6.54998  ? 300  ASN A ND2 1 
ATOM   2082 N N   A TYR A 1 220 ? 14.88266  -4.50792  -25.37224 0.876 6.86161  ? 301  TYR A N   1 
ATOM   2083 N N   B TYR A 1 220 ? 14.69815  -4.48627  -25.40762 0.124 6.85303  ? 301  TYR A N   1 
ATOM   2084 C CA  A TYR A 1 220 ? 14.07025  -4.64440  -26.57407 0.876 6.94836  ? 301  TYR A CA  1 
ATOM   2085 C CA  B TYR A 1 220 ? 13.95337  -4.90465  -26.59171 0.124 7.27963  ? 301  TYR A CA  1 
ATOM   2086 C C   A TYR A 1 220 ? 14.88889  -5.08498  -27.77882 0.876 7.44124  ? 301  TYR A C   1 
ATOM   2087 C C   B TYR A 1 220 ? 14.85078  -5.23650  -27.78257 0.124 7.34673  ? 301  TYR A C   1 
ATOM   2088 O O   A TYR A 1 220 ? 14.37489  -5.05943  -28.90683 0.876 7.79154  ? 301  TYR A O   1 
ATOM   2089 O O   B TYR A 1 220 ? 14.35297  -5.27361  -28.91412 0.124 7.38256  ? 301  TYR A O   1 
ATOM   2090 C CB  A TYR A 1 220 ? 13.37112  -3.31395  -26.89444 0.876 7.00541  ? 301  TYR A CB  1 
ATOM   2091 C CB  B TYR A 1 220 ? 12.93200  -3.82772  -27.05229 0.124 10.49880 ? 301  TYR A CB  1 
ATOM   2092 C CG  A TYR A 1 220 ? 12.52295  -2.75542  -25.77271 0.876 7.63079  ? 301  TYR A CG  1 
ATOM   2093 C CG  B TYR A 1 220 ? 12.32838  -2.98170  -25.94628 0.124 9.06460  ? 301  TYR A CG  1 
ATOM   2094 C CD1 A TYR A 1 220 ? 13.08334  -2.06948  -24.69812 0.876 7.68788  ? 301  TYR A CD1 1 
ATOM   2095 C CD1 B TYR A 1 220 ? 13.06780  -1.98803  -25.31415 0.124 8.55012  ? 301  TYR A CD1 1 
ATOM   2096 C CD2 A TYR A 1 220 ? 11.14814  -2.91434  -25.79653 0.876 7.49393  ? 301  TYR A CD2 1 
ATOM   2097 C CD2 B TYR A 1 220 ? 11.01445  -3.17288  -25.54139 0.124 8.22696  ? 301  TYR A CD2 1 
ATOM   2098 C CE1 A TYR A 1 220 ? 12.29128  -1.56929  -23.66997 0.876 9.42931  ? 301  TYR A CE1 1 
ATOM   2099 C CE1 B TYR A 1 220 ? 12.52426  -1.22040  -24.30412 0.124 7.66456  ? 301  TYR A CE1 1 
ATOM   2100 C CE2 A TYR A 1 220 ? 10.35228  -2.41543  -24.78856 0.876 8.84133  ? 301  TYR A CE2 1 
ATOM   2101 C CE2 B TYR A 1 220 ? 10.45837  -2.40366  -24.53576 0.124 8.58939  ? 301  TYR A CE2 1 
ATOM   2102 C CZ  A TYR A 1 220 ? 10.92185  -1.74673  -23.72321 0.876 8.94006  ? 301  TYR A CZ  1 
ATOM   2103 C CZ  B TYR A 1 220 ? 11.21704  -1.43132  -23.91864 0.124 8.02468  ? 301  TYR A CZ  1 
ATOM   2104 O OH  A TYR A 1 220 ? 10.09823  -1.25737  -22.72981 0.876 9.67931  ? 301  TYR A OH  1 
ATOM   2105 O OH  B TYR A 1 220 ? 10.65966  -0.66854  -22.91641 0.124 5.92548  ? 301  TYR A OH  1 
ATOM   2106 N N   . ASN A 1 221 ? 16.14516  -5.46952  -27.57562 1.000 7.69309  ? 302  ASN A N   1 
ATOM   2107 C CA  . ASN A 1 221 ? 17.02763  -5.76358  -28.69290 1.000 7.18571  ? 302  ASN A CA  1 
ATOM   2108 C C   . ASN A 1 221 ? 16.64324  -7.08440  -29.34967 1.000 6.61720  ? 302  ASN A C   1 
ATOM   2109 O O   . ASN A 1 221 ? 16.06414  -7.97776  -28.72389 1.000 7.70579  ? 302  ASN A O   1 
ATOM   2110 C CB  . ASN A 1 221 ? 18.46701  -5.89834  -28.21008 1.000 7.51726  ? 302  ASN A CB  1 
ATOM   2111 C CG  . ASN A 1 221 ? 19.06635  -4.59171  -27.72601 1.000 7.28373  ? 302  ASN A CG  1 
ATOM   2112 O OD1 . ASN A 1 221 ? 18.51274  -3.50959  -27.91030 1.000 8.07444  ? 302  ASN A OD1 1 
ATOM   2113 N ND2 . ASN A 1 221 ? 20.23959  -4.69404  -27.11788 1.000 8.26077  ? 302  ASN A ND2 1 
ATOM   2114 N N   . ALA A 1 222 ? 16.98653  -7.21052  -30.62824 1.000 7.70386  ? 303  ALA A N   1 
ATOM   2115 C CA  . ALA A 1 222 ? 16.87605  -8.49516  -31.29834 1.000 8.54398  ? 303  ALA A CA  1 
ATOM   2116 C C   . ALA A 1 222 ? 17.97060  -9.42707  -30.80671 1.000 8.07684  ? 303  ALA A C   1 
ATOM   2117 O O   . ALA A 1 222 ? 19.08126  -8.99524  -30.48415 1.000 8.64677  ? 303  ALA A O   1 
ATOM   2118 C CB  . ALA A 1 222 ? 17.05818  -8.31436  -32.80233 1.000 9.86031  ? 303  ALA A CB  1 
ATOM   2119 N N   . LEU A 1 223 ? 17.65564  -10.72390 -30.76167 1.000 8.77493  ? 304  LEU A N   1 
ATOM   2120 C CA  . LEU A 1 223 ? 18.71386  -11.72126 -30.67574 1.000 9.18646  ? 304  LEU A CA  1 
ATOM   2121 C C   . LEU A 1 223 ? 19.49163  -11.76002 -31.98304 1.000 8.68370  ? 304  LEU A C   1 
ATOM   2122 O O   . LEU A 1 223 ? 20.72609  -11.66693 -31.98634 1.000 9.05883  ? 304  LEU A O   1 
ATOM   2123 C CB  . LEU A 1 223 ? 18.14189  -13.09428 -30.31488 1.000 9.54515  ? 304  LEU A CB  1 
ATOM   2124 C CG  . LEU A 1 223 ? 19.13237  -14.26423 -30.32274 1.000 10.57876 ? 304  LEU A CG  1 
ATOM   2125 C CD1 . LEU A 1 223 ? 20.32467  -14.00865 -29.41014 1.000 10.14367 ? 304  LEU A CD1 1 
ATOM   2126 C CD2 . LEU A 1 223 ? 18.43426  -15.55652 -29.93917 1.000 12.56311 ? 304  LEU A CD2 1 
ATOM   2127 N N   A GLN A 1 224 ? 18.78665  -11.85973 -33.11036 0.780 10.08125 ? 305  GLN A N   1 
ATOM   2128 N N   B GLN A 1 224 ? 18.77863  -11.85102 -33.10663 0.220 10.27952 ? 305  GLN A N   1 
ATOM   2129 C CA  A GLN A 1 224 ? 19.42322  -11.87349 -34.42524 0.780 11.75337 ? 305  GLN A CA  1 
ATOM   2130 C CA  B GLN A 1 224 ? 19.37767  -11.87143 -34.43207 0.220 11.76911 ? 305  GLN A CA  1 
ATOM   2131 C C   A GLN A 1 224 ? 18.60677  -10.98647 -35.35633 0.780 10.92803 ? 305  GLN A C   1 
ATOM   2132 C C   B GLN A 1 224 ? 18.56397  -10.96313 -35.34273 0.220 11.13842 ? 305  GLN A C   1 
ATOM   2133 O O   A GLN A 1 224 ? 17.45312  -11.30486 -35.66916 0.780 15.17906 ? 305  GLN A O   1 
ATOM   2134 O O   B GLN A 1 224 ? 17.32976  -10.97120 -35.29534 0.220 10.98296 ? 305  GLN A O   1 
ATOM   2135 C CB  A GLN A 1 224 ? 19.51880  -13.29727 -34.97213 0.780 16.02939 ? 305  GLN A CB  1 
ATOM   2136 C CB  B GLN A 1 224 ? 19.38167  -13.29929 -34.99230 0.220 16.10810 ? 305  GLN A CB  1 
ATOM   2137 C CG  A GLN A 1 224 ? 19.93217  -13.38291 -36.43285 0.780 20.33110 ? 305  GLN A CG  1 
ATOM   2138 C CG  B GLN A 1 224 ? 20.18719  -14.28436 -34.15416 0.220 15.50309 ? 305  GLN A CG  1 
ATOM   2139 C CD  A GLN A 1 224 ? 20.82848  -14.57575 -36.71695 0.780 26.53832 ? 305  GLN A CD  1 
ATOM   2140 C CD  B GLN A 1 224 ? 20.79885  -15.40189 -34.97467 0.220 20.59954 ? 305  GLN A CD  1 
ATOM   2141 O OE1 A GLN A 1 224 ? 21.15965  -15.34984 -35.81731 0.780 26.65971 ? 305  GLN A OE1 1 
ATOM   2142 O OE1 B GLN A 1 224 ? 20.44615  -16.57118 -34.81218 0.220 18.70987 ? 305  GLN A OE1 1 
ATOM   2143 N NE2 A GLN A 1 224 ? 21.20780  -14.74161 -37.97901 0.780 29.54799 ? 305  GLN A NE2 1 
ATOM   2144 N NE2 B GLN A 1 224 ? 21.72511  -15.04937 -35.85894 0.220 22.50342 ? 305  GLN A NE2 1 
ATOM   2145 N N   A ALA A 1 225 ? 19.19583  -9.87809  -35.79828 0.780 10.73910 ? 306  ALA A N   1 
ATOM   2146 N N   B ALA A 1 225 ? 19.25290  -10.17721 -36.16791 0.220 14.20648 ? 306  ALA A N   1 
ATOM   2147 C CA  A ALA A 1 225 ? 18.55348  -8.97840  -36.74949 0.780 13.30136 ? 306  ALA A CA  1 
ATOM   2148 C CA  B ALA A 1 225 ? 18.57170  -9.25279  -37.06581 0.220 14.09487 ? 306  ALA A CA  1 
ATOM   2149 C C   A ALA A 1 225 ? 19.17072  -9.15776  -38.13196 0.780 14.16397 ? 306  ALA A C   1 
ATOM   2150 C C   B ALA A 1 225 ? 19.36706  -9.10891  -38.35334 0.220 14.37264 ? 306  ALA A C   1 
ATOM   2151 O O   A ALA A 1 225 ? 20.39690  -9.11236  -38.27809 0.780 15.72302 ? 306  ALA A O   1 
ATOM   2152 O O   B ALA A 1 225 ? 20.58219  -8.89350  -38.31498 0.220 14.79740 ? 306  ALA A O   1 
ATOM   2153 C CB  A ALA A 1 225 ? 18.70282  -7.52195  -36.30666 0.780 12.68424 ? 306  ALA A CB  1 
ATOM   2154 C CB  B ALA A 1 225 ? 18.38327  -7.88122  -36.40836 0.220 13.77488 ? 306  ALA A CB  1 
ATOM   2155 N N   A ALA A 1 226 ? 18.31695  -9.34630  -39.14499 0.780 18.05740 ? 307  ALA A N   1 
ATOM   2156 N N   B ALA A 1 226 ? 18.67211  -9.21921  -39.48727 0.220 16.01217 ? 307  ALA A N   1 
ATOM   2157 C CA  A ALA A 1 226 ? 18.80645  -9.44594  -40.51875 0.780 16.32104 ? 307  ALA A CA  1 
ATOM   2158 C CA  B ALA A 1 226 ? 19.32255  -9.06633  -40.78485 0.220 16.17057 ? 307  ALA A CA  1 
ATOM   2159 C C   A ALA A 1 226 ? 19.46189  -8.14506  -40.96231 0.780 16.45124 ? 307  ALA A C   1 
ATOM   2160 C C   B ALA A 1 226 ? 19.81408  -7.63741  -40.98483 0.220 16.66844 ? 307  ALA A C   1 
ATOM   2161 O O   A ALA A 1 226 ? 20.50075  -8.15640  -41.63385 0.780 20.25487 ? 307  ALA A O   1 
ATOM   2162 O O   B ALA A 1 226 ? 21.01471  -7.39735  -41.15928 0.220 18.87101 ? 307  ALA A O   1 
ATOM   2163 C CB  A ALA A 1 226 ? 17.66016  -9.81262  -41.46061 0.780 20.04166 ? 307  ALA A CB  1 
ATOM   2164 C CB  B ALA A 1 226 ? 18.35970  -9.47521  -41.90153 0.220 17.20198 ? 307  ALA A CB  1 
ATOM   2165 N N   A SER A 1 227 ? 18.86371  -7.01423  -40.60163 0.780 14.50401 ? 308  SER A N   1 
ATOM   2166 N N   B SER A 1 227 ? 18.89485  -6.67119  -40.96239 0.220 16.43517 ? 308  SER A N   1 
ATOM   2167 C CA  A SER A 1 227 ? 19.43166  -5.70052  -40.81245 0.780 12.87573 ? 308  SER A CA  1 
ATOM   2168 C CA  B SER A 1 227 ? 19.25296  -5.26717  -41.09389 0.220 14.98048 ? 308  SER A CA  1 
ATOM   2169 C C   A SER A 1 227 ? 19.52226  -4.98188  -39.47422 0.780 11.61862 ? 308  SER A C   1 
ATOM   2170 C C   B SER A 1 227 ? 19.23379  -4.61867  -39.72155 0.220 15.06335 ? 308  SER A C   1 
ATOM   2171 O O   A SER A 1 227 ? 18.57410  -5.04266  -38.68109 0.780 12.48161 ? 308  SER A O   1 
ATOM   2172 O O   B SER A 1 227 ? 18.19329  -4.65455  -39.04413 0.220 12.14570 ? 308  SER A O   1 
ATOM   2173 C CB  A SER A 1 227 ? 18.55375  -4.87666  -41.76731 0.780 15.85142 ? 308  SER A CB  1 
ATOM   2174 C CB  B SER A 1 227 ? 18.27605  -4.55685  -42.02065 0.220 16.65214 ? 308  SER A CB  1 
ATOM   2175 O OG  A SER A 1 227 ? 17.31767  -4.53750  -41.16403 0.780 24.40450 ? 308  SER A OG  1 
ATOM   2176 O OG  B SER A 1 227 ? 18.36476  -5.08055  -43.33306 0.220 14.38540 ? 308  SER A OG  1 
ATOM   2177 N N   A PRO A 1 228 ? 20.63440  -4.30457  -39.18870 0.780 10.74093 ? 309  PRO A N   1 
ATOM   2178 N N   B PRO A 1 228 ? 20.33803  -4.02753  -39.27292 0.220 12.54166 ? 309  PRO A N   1 
ATOM   2179 C CA  A PRO A 1 228 ? 20.76203  -3.62216  -37.89572 0.780 9.38510  ? 309  PRO A CA  1 
ATOM   2180 C CA  B PRO A 1 228 ? 20.38707  -3.48987  -37.90937 0.220 11.00925 ? 309  PRO A CA  1 
ATOM   2181 C C   A PRO A 1 228 ? 19.63972  -2.61917  -37.67435 0.780 9.57948  ? 309  PRO A C   1 
ATOM   2182 C C   B PRO A 1 228 ? 19.43928  -2.31720  -37.71274 0.220 12.97780 ? 309  PRO A C   1 
ATOM   2183 O O   A PRO A 1 228 ? 19.24173  -1.89133  -38.58757 0.780 10.80595 ? 309  PRO A O   1 
ATOM   2184 O O   B PRO A 1 228 ? 19.07992  -1.60480  -38.65318 0.220 11.85703 ? 309  PRO A O   1 
ATOM   2185 C CB  A PRO A 1 228 ? 22.11745  -2.91255  -38.00646 0.780 10.53431 ? 309  PRO A CB  1 
ATOM   2186 C CB  B PRO A 1 228 ? 21.84579  -3.03803  -37.75567 0.220 13.23716 ? 309  PRO A CB  1 
ATOM   2187 C CG  A PRO A 1 228 ? 22.87910  -3.72998  -38.98563 0.780 9.84321  ? 309  PRO A CG  1 
ATOM   2188 C CG  B PRO A 1 228 ? 22.39459  -2.97455  -39.14942 0.220 12.32595 ? 309  PRO A CG  1 
ATOM   2189 C CD  A PRO A 1 228 ? 21.86006  -4.17707  -39.99638 0.780 12.53659 ? 309  PRO A CD  1 
ATOM   2190 C CD  B PRO A 1 228 ? 21.65282  -4.00034  -39.93283 0.220 13.42677 ? 309  PRO A CD  1 
ATOM   2191 N N   A ASP A 1 229 ? 19.12814  -2.58498  -36.44789 0.780 8.50065  ? 310  ASP A N   1 
ATOM   2192 N N   B ASP A 1 229 ? 19.03495  -2.12996  -36.46198 0.220 11.29083 ? 310  ASP A N   1 
ATOM   2193 C CA  A ASP A 1 229 ? 18.24946  -1.49488  -36.05088 0.780 8.11403  ? 310  ASP A CA  1 
ATOM   2194 C CA  B ASP A 1 229 ? 18.24498  -0.96784  -36.09363 0.220 11.27418 ? 310  ASP A CA  1 
ATOM   2195 C C   A ASP A 1 229 ? 19.01657  -0.18711  -36.22395 0.780 8.91231  ? 310  ASP A C   1 
ATOM   2196 C C   B ASP A 1 229 ? 19.11697  0.28185   -36.21357 0.220 10.45020 ? 310  ASP A C   1 
ATOM   2197 O O   A ASP A 1 229 ? 20.17638  -0.10019  -35.79902 0.780 8.97037  ? 310  ASP A O   1 
ATOM   2198 O O   B ASP A 1 229 ? 20.27961  0.26940   -35.79592 0.220 10.60849 ? 310  ASP A O   1 
ATOM   2199 C CB  A ASP A 1 229 ? 17.85950  -1.69740  -34.58151 0.780 8.18095  ? 310  ASP A CB  1 
ATOM   2200 C CB  B ASP A 1 229 ? 17.75077  -1.14653  -34.65301 0.220 11.85225 ? 310  ASP A CB  1 
ATOM   2201 C CG  A ASP A 1 229 ? 16.74254  -0.76416  -34.10779 0.780 7.66522  ? 310  ASP A CG  1 
ATOM   2202 C CG  B ASP A 1 229 ? 16.78020  -0.06180  -34.20524 0.220 12.83819 ? 310  ASP A CG  1 
ATOM   2203 O OD1 A ASP A 1 229 ? 16.76011  0.44288   -34.44735 0.780 8.85063  ? 310  ASP A OD1 1 
ATOM   2204 O OD1 B ASP A 1 229 ? 17.06978  1.13924   -34.36930 0.220 12.83540 ? 310  ASP A OD1 1 
ATOM   2205 O OD2 A ASP A 1 229 ? 15.86474  -1.24527  -33.34968 0.780 7.78419  ? 310  ASP A OD2 1 
ATOM   2206 O OD2 B ASP A 1 229 ? 15.70995  -0.41576  -33.66823 0.220 15.64939 ? 310  ASP A OD2 1 
ATOM   2207 N N   A PRO A 1 230 ? 18.43178  0.83672   -36.85412 0.780 8.72125  ? 311  PRO A N   1 
ATOM   2208 N N   B PRO A 1 230 ? 18.59723  1.36581   -36.79800 0.220 11.05871 ? 311  PRO A N   1 
ATOM   2209 C CA  A PRO A 1 230 ? 19.19992  2.07161   -37.10618 0.780 9.05223  ? 311  PRO A CA  1 
ATOM   2210 C CA  B PRO A 1 230 ? 19.42981  2.56720   -36.98447 0.220 11.92710 ? 311  PRO A CA  1 
ATOM   2211 C C   A PRO A 1 230 ? 19.76622  2.72223   -35.85244 0.780 9.47517  ? 311  PRO A C   1 
ATOM   2212 C C   B PRO A 1 230 ? 19.95876  3.17401   -35.69385 0.220 11.90626 ? 311  PRO A C   1 
ATOM   2213 O O   A PRO A 1 230 ? 20.73684  3.48207   -35.95875 0.780 10.40692 ? 311  PRO A O   1 
ATOM   2214 O O   B PRO A 1 230 ? 20.96083  3.89908   -35.73538 0.220 12.59502 ? 311  PRO A O   1 
ATOM   2215 C CB  A PRO A 1 230 ? 18.18613  2.97838   -37.81360 0.780 10.97734 ? 311  PRO A CB  1 
ATOM   2216 C CB  B PRO A 1 230 ? 18.49920  3.53129   -37.73522 0.220 12.72759 ? 311  PRO A CB  1 
ATOM   2217 C CG  A PRO A 1 230 ? 17.24686  2.02088   -38.47415 0.780 13.43240 ? 311  PRO A CG  1 
ATOM   2218 C CG  B PRO A 1 230 ? 17.11555  3.04877   -37.40670 0.220 13.86612 ? 311  PRO A CG  1 
ATOM   2219 C CD  A PRO A 1 230 ? 17.11328  0.87073   -37.50991 0.780 9.83835  ? 311  PRO A CD  1 
ATOM   2220 C CD  B PRO A 1 230 ? 17.24124  1.55330   -37.34334 0.220 12.74248 ? 311  PRO A CD  1 
ATOM   2221 N N   A ILE A 1 231 ? 19.21747  2.43358   -34.66827 0.780 9.04860  ? 312  ILE A N   1 
ATOM   2222 N N   B ILE A 1 231 ? 19.33370  2.89820   -34.54725 0.220 9.23389  ? 312  ILE A N   1 
ATOM   2223 C CA  A ILE A 1 231 ? 19.74394  3.00879   -33.43436 0.780 8.25447  ? 312  ILE A CA  1 
ATOM   2224 C CA  B ILE A 1 231 ? 19.84951  3.39841   -33.27745 0.220 11.14977 ? 312  ILE A CA  1 
ATOM   2225 C C   A ILE A 1 231 ? 21.14460  2.52684   -33.09983 0.780 7.77216  ? 312  ILE A C   1 
ATOM   2226 C C   B ILE A 1 231 ? 21.16729  2.75471   -32.87721 0.220 9.79546  ? 312  ILE A C   1 
ATOM   2227 O O   A ILE A 1 231 ? 21.79875  3.13160   -32.24206 0.780 8.36932  ? 312  ILE A O   1 
ATOM   2228 O O   B ILE A 1 231 ? 21.79490  3.20010   -31.91042 0.220 9.55749  ? 312  ILE A O   1 
ATOM   2229 C CB  A ILE A 1 231 ? 18.82444  2.72596   -32.22782 0.780 8.32046  ? 312  ILE A CB  1 
ATOM   2230 C CB  B ILE A 1 231 ? 18.79095  3.28311   -32.16097 0.220 11.97501 ? 312  ILE A CB  1 
ATOM   2231 C CG1 A ILE A 1 231 ? 18.76086  1.22111   -31.95412 0.780 8.13572  ? 312  ILE A CG1 1 
ATOM   2232 C CG1 B ILE A 1 231 ? 18.71004  1.84085   -31.64374 0.220 10.93764 ? 312  ILE A CG1 1 
ATOM   2233 C CG2 A ILE A 1 231 ? 17.45253  3.33778   -32.45409 0.780 9.39274  ? 312  ILE A CG2 1 
ATOM   2234 C CG2 B ILE A 1 231 ? 17.44770  3.80021   -32.65564 0.220 10.18245 ? 312  ILE A CG2 1 
ATOM   2235 C CD1 A ILE A 1 231 ? 17.64279  0.79193   -31.02573 0.780 8.39287  ? 312  ILE A CD1 1 
ATOM   2236 C CD1 B ILE A 1 231 ? 17.32669  1.41815   -31.17432 0.220 10.85444 ? 312  ILE A CD1 1 
ATOM   2237 N N   A THR A 1 232 ? 21.62354  1.45960   -33.74193 0.780 7.97204  ? 313  THR A N   1 
ATOM   2238 N N   B THR A 1 232 ? 21.60663  1.72640   -33.60164 0.220 9.66827  ? 313  THR A N   1 
ATOM   2239 C CA  A THR A 1 232 ? 22.87943  0.81892   -33.37027 0.780 8.14443  ? 313  THR A CA  1 
ATOM   2240 C CA  B THR A 1 232 ? 22.83473  1.00646   -33.30133 0.220 8.54786  ? 313  THR A CA  1 
ATOM   2241 C C   A THR A 1 232 ? 24.10263  1.41147   -34.06442 0.780 8.48533  ? 313  THR A C   1 
ATOM   2242 C C   B THR A 1 232 ? 24.05049  1.57364   -34.03254 0.220 9.19704  ? 313  THR A C   1 
ATOM   2243 O O   A THR A 1 232 ? 25.20732  0.90164   -33.84471 0.780 7.62069  ? 313  THR A O   1 
ATOM   2244 O O   B THR A 1 232 ? 25.03131  0.84794   -34.23558 0.220 12.92259 ? 313  THR A O   1 
ATOM   2245 C CB  A THR A 1 232 ? 22.81531  -0.69038  -33.64668 0.780 9.01320  ? 313  THR A CB  1 
ATOM   2246 C CB  B THR A 1 232 ? 22.65643  -0.48130  -33.61769 0.220 8.32166  ? 313  THR A CB  1 
ATOM   2247 O OG1 A THR A 1 232 ? 22.71814  -0.92598  -35.05780 0.780 8.60772  ? 313  THR A OG1 1 
ATOM   2248 O OG1 B THR A 1 232 ? 22.42486  -0.64969  -35.02256 0.220 11.82835 ? 313  THR A OG1 1 
ATOM   2249 C CG2 A THR A 1 232 ? 21.62400  -1.32639  -32.93016 0.780 8.11014  ? 313  THR A CG2 1 
ATOM   2250 C CG2 B THR A 1 232 ? 21.47544  -1.05360  -32.84153 0.220 9.73972  ? 313  THR A CG2 1 
ATOM   2251 N N   A GLN A 1 233 ? 23.92887  2.46674   -34.87233 0.780 8.29616  ? 314  GLN A N   1 
ATOM   2252 N N   B GLN A 1 233 ? 24.00576  2.84934   -34.42012 0.220 9.74361  ? 314  GLN A N   1 
ATOM   2253 C CA  A GLN A 1 233 ? 25.02779  3.06448   -35.62732 0.780 8.72757  ? 314  GLN A CA  1 
ATOM   2254 C CA  B GLN A 1 233 ? 25.08415  3.45071   -35.19463 0.220 10.53953 ? 314  GLN A CA  1 
ATOM   2255 C C   A GLN A 1 233 ? 26.24169  3.27381   -34.74212 0.780 8.40342  ? 314  GLN A C   1 
ATOM   2256 C C   B GLN A 1 233 ? 26.38147  3.47383   -34.39816 0.220 9.92938  ? 314  GLN A C   1 
ATOM   2257 O O   A GLN A 1 233 ? 26.15673  3.91443   -33.69069 0.780 9.23035  ? 314  GLN A O   1 
ATOM   2258 O O   B GLN A 1 233 ? 26.41595  3.92286   -33.24849 0.220 9.74907  ? 314  GLN A O   1 
ATOM   2259 C CB  A GLN A 1 233 ? 24.64336  4.44738   -36.15607 0.780 13.94570 ? 314  GLN A CB  1 
ATOM   2260 C CB  B GLN A 1 233 ? 24.70501  4.87610   -35.59552 0.220 12.16098 ? 314  GLN A CB  1 
ATOM   2261 C CG  A GLN A 1 233 ? 23.43935  4.56642   -37.03474 0.780 18.96307 ? 314  GLN A CG  1 
ATOM   2262 C CG  B GLN A 1 233 ? 23.92850  4.97908   -36.89271 0.220 15.18189 ? 314  GLN A CG  1 
ATOM   2263 C CD  A GLN A 1 233 ? 22.97559  6.01249   -37.13005 0.780 21.09510 ? 314  GLN A CD  1 
ATOM   2264 C CD  B GLN A 1 233 ? 23.85259  6.40262   -37.40152 0.220 18.04932 ? 314  GLN A CD  1 
ATOM   2265 O OE1 A GLN A 1 233 ? 23.65968  6.85583   -37.71857 0.780 24.06603 ? 314  GLN A OE1 1 
ATOM   2266 O OE1 B GLN A 1 233 ? 22.90620  7.13247   -37.10180 0.220 16.47450 ? 314  GLN A OE1 1 
ATOM   2267 N NE2 A GLN A 1 233 ? 21.82708  6.31083   -36.53525 0.780 16.59430 ? 314  GLN A NE2 1 
ATOM   2268 N NE2 B GLN A 1 233 ? 24.85824  6.81075   -38.16609 0.220 17.23571 ? 314  GLN A NE2 1 
ATOM   2269 N N   A GLY A 1 234 ? 27.38575  2.79181   -35.20760 0.780 8.88248  ? 315  GLY A N   1 
ATOM   2270 N N   B GLY A 1 234 ? 27.45732  3.00299   -35.02601 0.220 9.40023  ? 315  GLY A N   1 
ATOM   2271 C CA  A GLY A 1 234 ? 28.63370  2.94502   -34.50377 0.780 9.48191  ? 315  GLY A CA  1 
ATOM   2272 C CA  B GLY A 1 234 ? 28.75857  2.97027   -34.40448 0.220 9.53707  ? 315  GLY A CA  1 
ATOM   2273 C C   A GLY A 1 234 ? 29.06909  1.71617   -33.73657 0.780 7.87705  ? 315  GLY A C   1 
ATOM   2274 C C   B GLY A 1 234 ? 29.11833  1.66486   -33.73071 0.220 7.99376  ? 315  GLY A C   1 
ATOM   2275 O O   A GLY A 1 234 ? 30.24138  1.62612   -33.34796 0.780 9.03823  ? 315  GLY A O   1 
ATOM   2276 O O   B GLY A 1 234 ? 30.29656  1.45816   -33.41096 0.220 9.00290  ? 315  GLY A O   1 
ATOM   2277 N N   . ASN A 1 235 ? 28.15233  0.77442   -33.50813 1.000 8.30440  ? 316  ASN A N   1 
ATOM   2278 C CA  . ASN A 1 235 ? 28.41033  -0.46311  -32.78222 1.000 8.29517  ? 316  ASN A CA  1 
ATOM   2279 C C   . ASN A 1 235 ? 28.24661  -1.63743  -33.73515 1.000 8.82935  ? 316  ASN A C   1 
ATOM   2280 O O   . ASN A 1 235 ? 27.11278  -1.93879  -34.13960 1.000 9.36688  ? 316  ASN A O   1 
ATOM   2281 C CB  . ASN A 1 235 ? 27.41479  -0.58715  -31.62565 1.000 7.58469  ? 316  ASN A CB  1 
ATOM   2282 C CG  . ASN A 1 235 ? 27.73545  -1.74479  -30.69950 1.000 7.16841  ? 316  ASN A CG  1 
ATOM   2283 O OD1 . ASN A 1 235 ? 28.56362  -2.58720  -31.01432 1.000 8.06289  ? 316  ASN A OD1 1 
ATOM   2284 N ND2 . ASN A 1 235 ? 27.06885  -1.79104  -29.54745 1.000 8.00003  ? 316  ASN A ND2 1 
ATOM   2285 N N   . PRO A 1 236 ? 29.31847  -2.34330  -34.10836 1.000 8.86559  ? 317  PRO A N   1 
ATOM   2286 C CA  . PRO A 1 236 ? 29.14968  -3.52111  -34.97338 1.000 9.50249  ? 317  PRO A CA  1 
ATOM   2287 C C   . PRO A 1 236 ? 28.37540  -4.64056  -34.30890 1.000 8.59318  ? 317  PRO A C   1 
ATOM   2288 O O   . PRO A 1 236 ? 27.86410  -5.52436  -35.00622 1.000 10.30699 ? 317  PRO A O   1 
ATOM   2289 C CB  . PRO A 1 236 ? 30.59212  -3.94606  -35.27120 1.000 11.79633 ? 317  PRO A CB  1 
ATOM   2290 C CG  . PRO A 1 236 ? 31.35668  -3.46714  -34.11030 1.000 12.35754 ? 317  PRO A CG  1 
ATOM   2291 C CD  . PRO A 1 236 ? 30.72253  -2.15349  -33.71358 1.000 9.13570  ? 317  PRO A CD  1 
ATOM   2292 N N   . ASN A 1 237 ? 28.27726  -4.64099  -32.97954 1.000 8.61016  ? 318  ASN A N   1 
ATOM   2293 C CA  . ASN A 1 237 ? 27.52177  -5.66923  -32.26928 1.000 9.53833  ? 318  ASN A CA  1 
ATOM   2294 C C   . ASN A 1 237 ? 26.10720  -5.15143  -32.05129 1.000 8.79444  ? 318  ASN A C   1 
ATOM   2295 O O   . ASN A 1 237 ? 25.73267  -4.67480  -30.97511 1.000 9.29283  ? 318  ASN A O   1 
ATOM   2296 C CB  . ASN A 1 237 ? 28.23212  -6.06312  -30.98538 1.000 10.22593 ? 318  ASN A CB  1 
ATOM   2297 C CG  . ASN A 1 237 ? 29.58016  -6.66651  -31.26913 1.000 9.60779  ? 318  ASN A CG  1 
ATOM   2298 O OD1 . ASN A 1 237 ? 29.73654  -7.37767  -32.26795 1.000 10.56760 ? 318  ASN A OD1 1 
ATOM   2299 N ND2 . ASN A 1 237 ? 30.56852  -6.37608  -30.42866 1.000 9.60540  ? 318  ASN A ND2 1 
ATOM   2300 N N   . TYR A 1 238 ? 25.31421  -5.24016  -33.12103 1.000 9.30849  ? 319  TYR A N   1 
ATOM   2301 C CA  . TYR A 1 238 ? 24.02249  -4.56985  -33.19765 1.000 9.72112  ? 319  TYR A CA  1 
ATOM   2302 C C   . TYR A 1 238 ? 22.86851  -5.41069  -32.66772 1.000 8.83872  ? 319  TYR A C   1 
ATOM   2303 O O   . TYR A 1 238 ? 21.73495  -4.91528  -32.62303 1.000 9.77115  ? 319  TYR A O   1 
ATOM   2304 C CB  . TYR A 1 238 ? 23.71077  -4.12929  -34.63594 1.000 10.30437 ? 319  TYR A CB  1 
ATOM   2305 C CG  . TYR A 1 238 ? 23.86419  -5.21464  -35.67850 1.000 9.70563  ? 319  TYR A CG  1 
ATOM   2306 C CD1 . TYR A 1 238 ? 22.80892  -6.06271  -35.98172 1.000 11.14890 ? 319  TYR A CD1 1 
ATOM   2307 C CD2 . TYR A 1 238 ? 25.03832  -5.34576  -36.40631 1.000 11.57432 ? 319  TYR A CD2 1 
ATOM   2308 C CE1 . TYR A 1 238 ? 22.93617  -7.04324  -36.94570 1.000 13.42372 ? 319  TYR A CE1 1 
ATOM   2309 C CE2 . TYR A 1 238 ? 25.17648  -6.32770  -37.37198 1.000 15.89294 ? 319  TYR A CE2 1 
ATOM   2310 C CZ  . TYR A 1 238 ? 24.12319  -7.17076  -37.63680 1.000 13.56376 ? 319  TYR A CZ  1 
ATOM   2311 O OH  . TYR A 1 238 ? 24.25492  -8.14579  -38.60039 1.000 18.61819 ? 319  TYR A OH  1 
ATOM   2312 N N   . ASP A 1 239 ? 23.12619  -6.65978  -32.28639 1.000 8.72911  ? 320  ASP A N   1 
ATOM   2313 C CA  . ASP A 1 239 ? 22.10873  -7.52600  -31.71964 1.000 8.50489  ? 320  ASP A CA  1 
ATOM   2314 C C   . ASP A 1 239 ? 22.75982  -8.38528  -30.64983 1.000 8.39947  ? 320  ASP A C   1 
ATOM   2315 O O   . ASP A 1 239 ? 23.97697  -8.35710  -30.45896 1.000 8.32623  ? 320  ASP A O   1 
ATOM   2316 C CB  . ASP A 1 239 ? 21.35402  -8.33456  -32.79464 1.000 9.67480  ? 320  ASP A CB  1 
ATOM   2317 C CG  . ASP A 1 239 ? 22.26874  -9.18113  -33.66986 1.000 9.24346  ? 320  ASP A CG  1 
ATOM   2318 O OD1 . ASP A 1 239 ? 23.41046  -9.45430  -33.25317 1.000 10.09057 ? 320  ASP A OD1 1 
ATOM   2319 O OD2 . ASP A 1 239 ? 21.82470  -9.58207  -34.77509 1.000 9.88960  ? 320  ASP A OD2 1 
ATOM   2320 N N   . GLU A 1 240 ? 21.93366  -9.13471  -29.92311 1.000 7.66622  ? 321  GLU A N   1 
ATOM   2321 C CA  . GLU A 1 240 ? 22.48188  -9.87237  -28.79308 1.000 7.85553  ? 321  GLU A CA  1 
ATOM   2322 C C   . GLU A 1 240 ? 23.41896  -10.99095 -29.23155 1.000 8.70176  ? 321  GLU A C   1 
ATOM   2323 O O   . GLU A 1 240 ? 24.39387  -11.27648 -28.52813 1.000 8.80433  ? 321  GLU A O   1 
ATOM   2324 C CB  . GLU A 1 240 ? 21.36788  -10.40903 -27.90287 1.000 8.31234  ? 321  GLU A CB  1 
ATOM   2325 C CG  . GLU A 1 240 ? 20.54320  -9.31580  -27.25729 1.000 7.95027  ? 321  GLU A CG  1 
ATOM   2326 C CD  . GLU A 1 240 ? 21.37983  -8.36913  -26.40823 1.000 7.32412  ? 321  GLU A CD  1 
ATOM   2327 O OE1 . GLU A 1 240 ? 21.95944  -8.82693  -25.40657 1.000 9.49733  ? 321  GLU A OE1 1 
ATOM   2328 O OE2 . GLU A 1 240 ? 21.45967  -7.16903  -26.74527 1.000 8.52123  ? 321  GLU A OE2 1 
ATOM   2329 N N   . ILE A 1 241 ? 23.15702  -11.63345 -30.37814 1.000 8.48533  ? 322  ILE A N   1 
ATOM   2330 C CA  . ILE A 1 241 ? 24.05011  -12.71281 -30.79073 1.000 9.07926  ? 322  ILE A CA  1 
ATOM   2331 C C   . ILE A 1 241 ? 25.44431  -12.17226 -31.09948 1.000 9.14224  ? 322  ILE A C   1 
ATOM   2332 O O   . ILE A 1 241 ? 26.45057  -12.81183 -30.78157 1.000 9.62861  ? 322  ILE A O   1 
ATOM   2333 C CB  . ILE A 1 241 ? 23.46018  -13.55414 -31.94033 1.000 9.54438  ? 322  ILE A CB  1 
ATOM   2334 C CG1 . ILE A 1 241 ? 24.28968  -14.81510 -32.14026 1.000 14.85796 ? 322  ILE A CG1 1 
ATOM   2335 C CG2 . ILE A 1 241 ? 23.48363  -12.80168 -33.24875 1.000 11.73697 ? 322  ILE A CG2 1 
ATOM   2336 C CD1 . ILE A 1 241 ? 24.19624  -15.75594 -31.00425 1.000 22.30767 ? 322  ILE A CD1 1 
ATOM   2337 N N   . HIS A 1 242 ? 25.53453  -10.98131 -31.70538 1.000 8.95645  ? 323  HIS A N   1 
ATOM   2338 C CA  . HIS A 1 242 ? 26.85540  -10.40326 -31.95090 1.000 8.56474  ? 323  HIS A CA  1 
ATOM   2339 C C   . HIS A 1 242 ? 27.56633  -10.09135 -30.64133 1.000 8.15733  ? 323  HIS A C   1 
ATOM   2340 O O   . HIS A 1 242 ? 28.76675  -10.34316 -30.50024 1.000 9.31180  ? 323  HIS A O   1 
ATOM   2341 C CB  . HIS A 1 242 ? 26.75016  -9.11370  -32.76518 1.000 9.84473  ? 323  HIS A CB  1 
ATOM   2342 C CG  . HIS A 1 242 ? 26.65496  -9.31300  -34.24332 1.000 10.59987 ? 323  HIS A CG  1 
ATOM   2343 N ND1 . HIS A 1 242 ? 25.48409  -9.66951  -34.87619 1.000 11.30713 ? 323  HIS A ND1 1 
ATOM   2344 C CD2 . HIS A 1 242 ? 27.57476  -9.15079  -35.22296 1.000 13.37282 ? 323  HIS A CD2 1 
ATOM   2345 C CE1 . HIS A 1 242 ? 25.69244  -9.74699  -36.17824 1.000 13.53560 ? 323  HIS A CE1 1 
ATOM   2346 N NE2 . HIS A 1 242 ? 26.95359  -9.43504  -36.41510 1.000 15.96568 ? 323  HIS A NE2 1 
ATOM   2347 N N   . TYR A 1 243 ? 26.84343  -9.51612  -29.67984 1.000 7.89210  ? 324  TYR A N   1 
ATOM   2348 C CA  . TYR A 1 243 ? 27.42136  -9.20510  -28.37773 1.000 8.11452  ? 324  TYR A CA  1 
ATOM   2349 C C   . TYR A 1 243 ? 27.95072  -10.46530 -27.70798 1.000 7.56608  ? 324  TYR A C   1 
ATOM   2350 O O   . TYR A 1 243 ? 29.10509  -10.51784 -27.27712 1.000 8.27424  ? 324  TYR A O   1 
ATOM   2351 C CB  . TYR A 1 243 ? 26.34534  -8.50978  -27.52958 1.000 7.65636  ? 324  TYR A CB  1 
ATOM   2352 C CG  . TYR A 1 243 ? 26.59674  -8.39297  -26.03478 1.000 7.55653  ? 324  TYR A CG  1 
ATOM   2353 C CD1 . TYR A 1 243 ? 27.87478  -8.18316  -25.52739 1.000 7.62458  ? 324  TYR A CD1 1 
ATOM   2354 C CD2 . TYR A 1 243 ? 25.53783  -8.46302  -25.12931 1.000 8.10218  ? 324  TYR A CD2 1 
ATOM   2355 C CE1 . TYR A 1 243 ? 28.09393  -8.06450  -24.17664 1.000 7.67369  ? 324  TYR A CE1 1 
ATOM   2356 C CE2 . TYR A 1 243 ? 25.75029  -8.34771  -23.77638 1.000 8.04760  ? 324  TYR A CE2 1 
ATOM   2357 C CZ  . TYR A 1 243 ? 27.03343  -8.15020  -23.29992 1.000 7.48512  ? 324  TYR A CZ  1 
ATOM   2358 O OH  . TYR A 1 243 ? 27.27723  -8.04317  -21.95169 1.000 7.89449  ? 324  TYR A OH  1 
ATOM   2359 N N   . ILE A 1 244 ? 27.11978  -11.50142 -27.63739 1.000 7.74377  ? 325  ILE A N   1 
ATOM   2360 C CA  . ILE A 1 244 ? 27.50099  -12.73147 -26.95780 1.000 8.24921  ? 325  ILE A CA  1 
ATOM   2361 C C   . ILE A 1 244 ? 28.65445  -13.41974 -27.67429 1.000 8.25937  ? 325  ILE A C   1 
ATOM   2362 O O   . ILE A 1 244 ? 29.59501  -13.90380 -27.03282 1.000 8.62056  ? 325  ILE A O   1 
ATOM   2363 C CB  . ILE A 1 244 ? 26.25835  -13.62511 -26.80113 1.000 9.22256  ? 325  ILE A CB  1 
ATOM   2364 C CG1 . ILE A 1 244 ? 25.29744  -12.95991 -25.81353 1.000 8.92605  ? 325  ILE A CG1 1 
ATOM   2365 C CG2 . ILE A 1 244 ? 26.62787  -15.02411 -26.36650 1.000 9.45629  ? 325  ILE A CG2 1 
ATOM   2366 C CD1 . ILE A 1 244 ? 23.90791  -13.52135 -25.83761 1.000 10.08087 ? 325  ILE A CD1 1 
ATOM   2367 N N   A ASN A 1 245 ? 28.61216  -13.45813 -29.01046 0.892 8.77939  ? 326  ASN A N   1 
ATOM   2368 N N   B ASN A 1 245 ? 28.60813  -13.47477 -29.00799 0.108 8.86916  ? 326  ASN A N   1 
ATOM   2369 C CA  A ASN A 1 245 ? 29.70093  -14.06454 -29.77287 0.892 9.91290  ? 326  ASN A CA  1 
ATOM   2370 C CA  B ASN A 1 245 ? 29.72336  -14.04082 -29.75735 0.108 10.00505 ? 326  ASN A CA  1 
ATOM   2371 C C   A ASN A 1 245 ? 31.02513  -13.37305 -29.49410 0.892 9.04931  ? 326  ASN A C   1 
ATOM   2372 C C   B ASN A 1 245 ? 30.95042  -13.13699 -29.73467 0.108 10.77515 ? 326  ASN A C   1 
ATOM   2373 O O   A ASN A 1 245 ? 32.08308  -14.01213 -29.53588 0.892 9.60430  ? 326  ASN A O   1 
ATOM   2374 O O   B ASN A 1 245 ? 32.04612  -13.59086 -30.08187 0.108 11.14960 ? 326  ASN A O   1 
ATOM   2375 C CB  A ASN A 1 245 ? 29.42168  -13.93617 -31.26826 0.892 10.76488 ? 326  ASN A CB  1 
ATOM   2376 C CB  B ASN A 1 245 ? 29.30335  -14.36582 -31.19358 0.108 10.04909 ? 326  ASN A CB  1 
ATOM   2377 C CG  A ASN A 1 245 ? 28.45730  -14.97104 -31.76634 0.892 11.15927 ? 326  ASN A CG  1 
ATOM   2378 C CG  B ASN A 1 245 ? 28.06455  -15.24527 -31.25591 0.108 12.31036 ? 326  ASN A CG  1 
ATOM   2379 O OD1 A ASN A 1 245 ? 28.13973  -15.92412 -31.06209 0.892 13.16024 ? 326  ASN A OD1 1 
ATOM   2380 O OD1 B ASN A 1 245 ? 27.57928  -15.72684 -30.23204 0.108 13.67969 ? 326  ASN A OD1 1 
ATOM   2381 N ND2 A ASN A 1 245 ? 27.96218  -14.78270 -32.97991 0.892 13.13682 ? 326  ASN A ND2 1 
ATOM   2382 N ND2 B ASN A 1 245 ? 27.54554  -15.45434 -32.46078 0.108 11.31253 ? 326  ASN A ND2 1 
ATOM   2383 N N   A ALA A 1 246 ? 30.98206  -12.06198 -29.24366 0.892 9.01337  ? 327  ALA A N   1 
ATOM   2384 N N   B ALA A 1 246 ? 30.79462  -11.87502 -29.33365 0.108 8.80682  ? 327  ALA A N   1 
ATOM   2385 C CA  A ALA A 1 246 ? 32.19875  -11.29734 -29.01279 0.892 9.13915  ? 327  ALA A CA  1 
ATOM   2386 C CA  B ALA A 1 246 ? 31.92841  -10.98325 -29.13482 0.108 9.82192  ? 327  ALA A CA  1 
ATOM   2387 C C   A ALA A 1 246 ? 32.67389  -11.40632 -27.57335 0.892 8.37540  ? 327  ALA A C   1 
ATOM   2388 C C   B ALA A 1 246 ? 32.34896  -10.86683 -27.67573 0.108 10.04134 ? 327  ALA A C   1 
ATOM   2389 O O   A ALA A 1 246 ? 33.88067  -11.41815 -27.32436 0.892 9.00690  ? 327  ALA A O   1 
ATOM   2390 O O   B ALA A 1 246 ? 33.44497  -10.36476 -27.40350 0.108 11.60344 ? 327  ALA A O   1 
ATOM   2391 C CB  A ALA A 1 246 ? 31.96449  -9.83264  -29.38131 0.892 9.40039  ? 327  ALA A CB  1 
ATOM   2392 C CB  B ALA A 1 246 ? 31.63321  -9.58700  -29.69800 0.108 9.06891  ? 327  ALA A CB  1 
ATOM   2393 N N   A LEU A 1 247 ? 31.74995  -11.48374 -26.61412 0.892 7.85321  ? 328  LEU A N   1 
ATOM   2394 N N   B LEU A 1 247 ? 31.51622  -11.31710 -26.73717 0.108 8.17830  ? 328  LEU A N   1 
ATOM   2395 C CA  A LEU A 1 247 ? 32.13436  -11.49884 -25.20657 0.892 8.17995  ? 328  LEU A CA  1 
ATOM   2396 C CA  B LEU A 1 247 ? 31.84854  -11.28872 -25.31733 0.108 8.74049  ? 328  LEU A CA  1 
ATOM   2397 C C   A LEU A 1 247 ? 32.57337  -12.88694 -24.75011 0.892 7.79161  ? 328  LEU A C   1 
ATOM   2398 C C   B LEU A 1 247 ? 32.27771  -12.64696 -24.77649 0.108 9.24967  ? 328  LEU A C   1 
ATOM   2399 O O   A LEU A 1 247 ? 33.54268  -13.01970 -23.99657 0.892 8.60053  ? 328  LEU A O   1 
ATOM   2400 O O   B LEU A 1 247 ? 33.24076  -12.72221 -24.00818 0.108 9.85925  ? 328  LEU A O   1 
ATOM   2401 C CB  A LEU A 1 247 ? 30.96878  -10.99686 -24.34783 0.892 7.58774  ? 328  LEU A CB  1 
ATOM   2402 C CB  B LEU A 1 247 ? 30.65881  -10.78161 -24.49429 0.108 7.82362  ? 328  LEU A CB  1 
ATOM   2403 C CG  A LEU A 1 247 ? 31.20772  -11.00710 -22.83710 0.892 8.29533  ? 328  LEU A CG  1 
ATOM   2404 C CG  B LEU A 1 247 ? 30.89982  -10.72814 -22.98113 0.108 7.46705  ? 328  LEU A CG  1 
ATOM   2405 C CD1 A LEU A 1 247 ? 32.35733  -10.08618 -22.44879 0.892 11.01972 ? 328  LEU A CD1 1 
ATOM   2406 C CD1 B LEU A 1 247 ? 32.06289  -9.79620  -22.64526 0.108 7.37639  ? 328  LEU A CD1 1 
ATOM   2407 C CD2 A LEU A 1 247 ? 29.95828  -10.64161 -22.07263 0.892 8.83459  ? 328  LEU A CD2 1 
ATOM   2408 C CD2 B LEU A 1 247 ? 29.64571  -10.34515 -22.20891 0.108 8.91309  ? 328  LEU A CD2 1 
ATOM   2409 N N   A ALA A 1 248 ? 31.86166  -13.92530 -25.17721 0.892 8.69972  ? 329  ALA A N   1 
ATOM   2410 N N   B ALA A 1 248 ? 31.58696  -13.72006 -25.16394 0.108 9.45278  ? 329  ALA A N   1 
ATOM   2411 C CA  A ALA A 1 248 ? 32.12116  -15.26849 -24.66398 0.892 9.34485  ? 329  ALA A CA  1 
ATOM   2412 C CA  B ALA A 1 248 ? 31.84009  -15.02945 -24.56387 0.108 9.94599  ? 329  ALA A CA  1 
ATOM   2413 C C   A ALA A 1 248 ? 33.57007  -15.72171 -24.78690 0.892 8.55347  ? 329  ALA A C   1 
ATOM   2414 C C   B ALA A 1 248 ? 33.27795  -15.53089 -24.68719 0.108 9.44829  ? 329  ALA A C   1 
ATOM   2415 O O   A ALA A 1 248 ? 34.09139  -16.28264 -23.80832 0.892 9.47960  ? 329  ALA A O   1 
ATOM   2416 O O   B ALA A 1 248 ? 33.77820  -16.10897 -23.70631 0.108 9.85869  ? 329  ALA A O   1 
ATOM   2417 C CB  A ALA A 1 248 ? 31.15176  -16.28117 -25.28845 0.892 10.39082 ? 329  ALA A CB  1 
ATOM   2418 C CB  B ALA A 1 248 ? 30.82821  -16.06268 -25.07954 0.108 10.05022 ? 329  ALA A CB  1 
ATOM   2419 N N   A PRO A 1 249 ? 34.26779  -15.52654 -25.91258 0.892 10.40165 ? 330  PRO A N   1 
ATOM   2420 N N   B PRO A 1 249 ? 33.97684  -15.38554 -25.82249 0.108 9.77834  ? 330  PRO A N   1 
ATOM   2421 C CA  A PRO A 1 249 ? 35.66956  -15.97117 -25.97037 0.892 10.09915 ? 330  PRO A CA  1 
ATOM   2422 C CA  B PRO A 1 249 ? 35.36040  -15.90494 -25.88796 0.108 10.58179 ? 330  PRO A CA  1 
ATOM   2423 C C   A PRO A 1 249 ? 36.56067  -15.27025 -24.96969 0.892 9.23249  ? 330  PRO A C   1 
ATOM   2424 C C   B PRO A 1 249 ? 36.29457  -15.33947 -24.82539 0.108 9.57895  ? 330  PRO A C   1 
ATOM   2425 O O   A PRO A 1 249 ? 37.55334  -15.86382 -24.52345 0.892 10.43573 ? 330  PRO A O   1 
ATOM   2426 O O   B PRO A 1 249 ? 37.07661  -16.08956 -24.22575 0.108 11.22002 ? 330  PRO A O   1 
ATOM   2427 C CB  A PRO A 1 249 ? 36.08814  -15.66610 -27.41709 0.892 11.41477 ? 330  PRO A CB  1 
ATOM   2428 C CB  B PRO A 1 249 ? 35.80092  -15.52296 -27.30616 0.108 12.36886 ? 330  PRO A CB  1 
ATOM   2429 C CG  A PRO A 1 249 ? 34.81363  -15.53752 -28.17127 0.892 14.72450 ? 330  PRO A CG  1 
ATOM   2430 C CG  B PRO A 1 249 ? 34.54557  -15.52191 -28.09476 0.108 13.16330 ? 330  PRO A CG  1 
ATOM   2431 C CD  A PRO A 1 249 ? 33.82467  -14.97206 -27.20377 0.892 10.33046 ? 330  PRO A CD  1 
ATOM   2432 C CD  B PRO A 1 249 ? 33.46092  -15.04460 -27.16333 0.108 9.46757  ? 330  PRO A CD  1 
ATOM   2433 N N   . LEU A 1 250 ? 36.24478  -14.02310 -24.59947 1.000 10.40932 ? 331  LEU A N   1 
ATOM   2434 C CA  . LEU A 1 250 ? 37.06055  -13.36748 -23.58202 1.000 10.20927 ? 331  LEU A CA  1 
ATOM   2435 C C   . LEU A 1 250 ? 36.90911  -14.04853 -22.23340 1.000 9.78102  ? 331  LEU A C   1 
ATOM   2436 O O   . LEU A 1 250 ? 37.88476  -14.19639 -21.48665 1.000 10.27900 ? 331  LEU A O   1 
ATOM   2437 C CB  . LEU A 1 250 ? 36.66485  -11.89437 -23.46740 1.000 10.12628 ? 331  LEU A CB  1 
ATOM   2438 C CG  . LEU A 1 250 ? 36.53221  -11.10731 -24.77326 1.000 13.29390 ? 331  LEU A CG  1 
ATOM   2439 C CD1 . LEU A 1 250 ? 36.22846  -9.64344  -24.49043 1.000 12.94936 ? 331  LEU A CD1 1 
ATOM   2440 C CD2 . LEU A 1 250 ? 37.78509  -11.24384 -25.59412 1.000 14.19675 ? 331  LEU A CD2 1 
ATOM   2441 N N   . LEU A 1 251 ? 35.68197  -14.44672 -21.89317 1.000 9.11369  ? 332  LEU A N   1 
ATOM   2442 C CA  . LEU A 1 251 ? 35.47106  -15.21171 -20.67139 1.000 8.75533  ? 332  LEU A CA  1 
ATOM   2443 C C   . LEU A 1 251 ? 36.17640  -16.56114 -20.74285 1.000 9.06089  ? 332  LEU A C   1 
ATOM   2444 O O   . LEU A 1 251 ? 36.81868  -16.98436 -19.77547 1.000 9.98262  ? 332  LEU A O   1 
ATOM   2445 C CB  . LEU A 1 251 ? 33.97124  -15.37726 -20.43042 1.000 8.53857  ? 332  LEU A CB  1 
ATOM   2446 C CG  . LEU A 1 251 ? 33.20425  -14.05565 -20.32060 1.000 9.69865  ? 332  LEU A CG  1 
ATOM   2447 C CD1 . LEU A 1 251 ? 31.69229  -14.27742 -20.21803 1.000 10.94867 ? 332  LEU A CD1 1 
ATOM   2448 C CD2 . LEU A 1 251 ? 33.70115  -13.24539 -19.13313 1.000 11.65501 ? 332  LEU A CD2 1 
ATOM   2449 N N   . GLN A 1 252 ? 36.07439  -17.24734 -21.88624 1.000 9.78253  ? 333  GLN A N   1 
ATOM   2450 C CA  . GLN A 1 252 ? 36.76533  -18.52703 -22.04554 1.000 10.79903 ? 333  GLN A CA  1 
ATOM   2451 C C   . GLN A 1 252 ? 38.26686  -18.39566 -21.81799 1.000 10.00431 ? 333  GLN A C   1 
ATOM   2452 O O   . GLN A 1 252 ? 38.87881  -19.23990 -21.15172 1.000 11.79998 ? 333  GLN A O   1 
ATOM   2453 C CB  . GLN A 1 252 ? 36.49047  -19.11577 -23.42679 1.000 11.27407 ? 333  GLN A CB  1 
ATOM   2454 C CG  . GLN A 1 252 ? 35.05239  -19.49360 -23.65230 1.000 12.20198 ? 333  GLN A CG  1 
ATOM   2455 C CD  . GLN A 1 252 ? 34.80258  -20.00877 -25.05346 1.000 13.30199 ? 333  GLN A CD  1 
ATOM   2456 O OE1 . GLN A 1 252 ? 35.37383  -19.50780 -26.02398 1.000 14.15536 ? 333  GLN A OE1 1 
ATOM   2457 N NE2 . GLN A 1 252 ? 33.94310  -21.01512 -25.16987 1.000 17.69328 ? 333  GLN A NE2 1 
ATOM   2458 N N   . GLN A 1 253 ? 38.88616  -17.35170 -22.36556 1.000 11.63938 ? 334  GLN A N   1 
ATOM   2459 C CA  . GLN A 1 253 ? 40.32809  -17.19019 -22.19562 1.000 12.59681 ? 334  GLN A CA  1 
ATOM   2460 C C   . GLN A 1 253 ? 40.70755  -16.82508 -20.76726 1.000 11.86925 ? 334  GLN A C   1 
ATOM   2461 O O   . GLN A 1 253 ? 41.86360  -17.01942 -20.37286 1.000 13.80518 ? 334  GLN A O   1 
ATOM   2462 C CB  . GLN A 1 253 ? 40.87085  -16.17012 -23.19493 1.000 13.87146 ? 334  GLN A CB  1 
ATOM   2463 C CG  . GLN A 1 253 ? 40.56841  -16.51296 -24.64448 1.000 16.57215 ? 334  GLN A CG  1 
ATOM   2464 C CD  . GLN A 1 253 ? 41.44928  -15.75473 -25.61536 1.000 18.54204 ? 334  GLN A CD  1 
ATOM   2465 O OE1 . GLN A 1 253 ? 42.32115  -14.98294 -25.21131 1.000 24.93761 ? 334  GLN A OE1 1 
ATOM   2466 N NE2 . GLN A 1 253 ? 41.22364  -15.96612 -26.90512 1.000 22.42133 ? 334  GLN A NE2 1 
ATOM   2467 N N   . ALA A 1 254 ? 39.76676  -16.30382 -19.98773 1.000 11.68183 ? 335  ALA A N   1 
ATOM   2468 C CA  . ALA A 1 254 ? 39.97708  -16.09229 -18.56469 1.000 11.80915 ? 335  ALA A CA  1 
ATOM   2469 C C   . ALA A 1 254 ? 39.66439  -17.33138 -17.73432 1.000 13.29562 ? 335  ALA A C   1 
ATOM   2470 O O   . ALA A 1 254 ? 39.78569  -17.27932 -16.50663 1.000 16.12366 ? 335  ALA A O   1 
ATOM   2471 C CB  . ALA A 1 254 ? 39.14905  -14.90182 -18.07313 1.000 13.59366 ? 335  ALA A CB  1 
ATOM   2472 N N   . GLY A 1 255 ? 39.26027  -18.43372 -18.36774 1.000 11.52352 ? 336  GLY A N   1 
ATOM   2473 C CA  . GLY A 1 255 ? 39.00793  -19.68611 -17.68892 1.000 13.27472 ? 336  GLY A CA  1 
ATOM   2474 C C   . GLY A 1 255 ? 37.55039  -20.06256 -17.50614 1.000 10.85772 ? 336  GLY A C   1 
ATOM   2475 O O   . GLY A 1 255 ? 37.27131  -21.16683 -17.02238 1.000 13.46112 ? 336  GLY A O   1 
ATOM   2476 N N   . TRP A 1 256 ? 36.61171  -19.20310 -17.88464 1.000 10.68367 ? 337  TRP A N   1 
ATOM   2477 C CA  . TRP A 1 256 ? 35.19122  -19.41560 -17.62307 1.000 9.95555  ? 337  TRP A CA  1 
ATOM   2478 C C   . TRP A 1 256 ? 34.48482  -19.69354 -18.93920 1.000 9.65600  ? 337  TRP A C   1 
ATOM   2479 O O   . TRP A 1 256 ? 34.30400  -18.78963 -19.76119 1.000 9.96035  ? 337  TRP A O   1 
ATOM   2480 C CB  . TRP A 1 256 ? 34.60183  -18.18148 -16.95995 1.000 9.63260  ? 337  TRP A CB  1 
ATOM   2481 C CG  . TRP A 1 256 ? 33.18828  -18.31351 -16.51743 1.000 8.54636  ? 337  TRP A CG  1 
ATOM   2482 C CD1 . TRP A 1 256 ? 32.43872  -19.45121 -16.41037 1.000 10.36124 ? 337  TRP A CD1 1 
ATOM   2483 C CD2 . TRP A 1 256 ? 32.35767  -17.24456 -16.10472 1.000 8.55663  ? 337  TRP A CD2 1 
ATOM   2484 N NE1 . TRP A 1 256 ? 31.17837  -19.14383 -15.94818 1.000 10.53219 ? 337  TRP A NE1 1 
ATOM   2485 C CE2 . TRP A 1 256 ? 31.10802  -17.79124 -15.75688 1.000 9.45371  ? 337  TRP A CE2 1 
ATOM   2486 C CE3 . TRP A 1 256 ? 32.54408  -15.86600 -15.99639 1.000 11.19784 ? 337  TRP A CE3 1 
ATOM   2487 C CZ2 . TRP A 1 256 ? 30.05648  -17.01134 -15.30102 1.000 11.65624 ? 337  TRP A CZ2 1 
ATOM   2488 C CZ3 . TRP A 1 256 ? 31.48994  -15.09221 -15.54507 1.000 14.47793 ? 337  TRP A CZ3 1 
ATOM   2489 C CH2 . TRP A 1 256 ? 30.26173  -15.66841 -15.20732 1.000 13.32839 ? 337  TRP A CH2 1 
ATOM   2490 N N   A ASP A 1 257 ? 34.06941  -20.94105 -19.12827 0.597 10.03380 ? 338  ASP A N   1 
ATOM   2491 N N   B ASP A 1 257 ? 34.09570  -20.95106 -19.15108 0.403 10.09567 ? 338  ASP A N   1 
ATOM   2492 C CA  A ASP A 1 257 ? 33.31876  -21.33180 -20.31787 0.597 9.70099  ? 338  ASP A CA  1 
ATOM   2493 C CA  B ASP A 1 257 ? 33.31386  -21.32342 -20.33179 0.403 9.68842  ? 338  ASP A CA  1 
ATOM   2494 C C   A ASP A 1 257 ? 31.84912  -20.95396 -20.11650 0.597 10.25708 ? 338  ASP A C   1 
ATOM   2495 C C   B ASP A 1 257 ? 31.85200  -20.95018 -20.08951 0.403 10.23889 ? 338  ASP A C   1 
ATOM   2496 O O   A ASP A 1 257 ? 30.95671  -21.79553 -19.99640 0.597 10.76574 ? 338  ASP A O   1 
ATOM   2497 O O   B ASP A 1 257 ? 30.96970  -21.79307 -19.91507 0.403 10.77184 ? 338  ASP A O   1 
ATOM   2498 C CB  A ASP A 1 257 ? 33.49457  -22.82133 -20.57240 0.597 11.85799 ? 338  ASP A CB  1 
ATOM   2499 C CB  B ASP A 1 257 ? 33.46083  -22.80428 -20.64816 0.403 11.91223 ? 338  ASP A CB  1 
ATOM   2500 C CG  A ASP A 1 257 ? 33.21345  -23.20434 -22.00536 0.597 14.26955 ? 338  ASP A CG  1 
ATOM   2501 C CG  B ASP A 1 257 ? 34.81934  -23.15066 -21.19545 0.403 13.75895 ? 338  ASP A CG  1 
ATOM   2502 O OD1 A ASP A 1 257 ? 32.95423  -22.30275 -22.82983 0.597 12.70793 ? 338  ASP A OD1 1 
ATOM   2503 O OD1 B ASP A 1 257 ? 35.55413  -22.22880 -21.60652 0.403 14.30925 ? 338  ASP A OD1 1 
ATOM   2504 O OD2 A ASP A 1 257 ? 33.24049  -24.41619 -22.30419 0.597 15.61301 ? 338  ASP A OD2 1 
ATOM   2505 O OD2 B ASP A 1 257 ? 35.15134  -24.35264 -21.22760 0.403 18.98594 ? 338  ASP A OD2 1 
ATOM   2506 N N   . ALA A 1 258 ? 31.60911  -19.64615 -20.08419 1.000 8.89045  ? 339  ALA A N   1 
ATOM   2507 C CA  . ALA A 1 258 ? 30.30694  -19.12652 -19.69901 1.000 8.79288  ? 339  ALA A CA  1 
ATOM   2508 C C   . ALA A 1 258 ? 29.26847  -19.35642 -20.78371 1.000 8.24478  ? 339  ALA A C   1 
ATOM   2509 O O   . ALA A 1 258 ? 29.55520  -19.24323 -21.97812 1.000 9.08954  ? 339  ALA A O   1 
ATOM   2510 C CB  . ALA A 1 258 ? 30.43207  -17.62892 -19.43832 1.000 9.74733  ? 339  ALA A CB  1 
ATOM   2511 N N   . THR A 1 259 ? 28.04131  -19.64904 -20.35958 1.000 7.52647  ? 340  THR A N   1 
ATOM   2512 C CA  . THR A 1 259 ? 26.91072  -19.68167 -21.27047 1.000 8.34048  ? 340  THR A CA  1 
ATOM   2513 C C   . THR A 1 259 ? 25.91329  -18.60240 -20.87949 1.000 7.45654  ? 340  THR A C   1 
ATOM   2514 O O   . THR A 1 259 ? 26.04751  -17.93711 -19.84795 1.000 9.10463  ? 340  THR A O   1 
ATOM   2515 C CB  . THR A 1 259 ? 26.26684  -21.06703 -21.33619 1.000 9.06169  ? 340  THR A CB  1 
ATOM   2516 O OG1 . THR A 1 259 ? 26.05058  -21.55056 -20.01349 1.000 10.18697 ? 340  THR A OG1 1 
ATOM   2517 C CG2 . THR A 1 259 ? 27.17956  -22.03346 -22.08497 1.000 12.29017 ? 340  THR A CG2 1 
ATOM   2518 N N   . PHE A 1 260 ? 24.90954  -18.41631 -21.72963 1.000 7.27018  ? 341  PHE A N   1 
ATOM   2519 C CA  . PHE A 1 260 ? 24.10822  -17.20779 -21.67464 1.000 7.05791  ? 341  PHE A CA  1 
ATOM   2520 C C   . PHE A 1 260 ? 22.62491  -17.52726 -21.79507 1.000 7.03735  ? 341  PHE A C   1 
ATOM   2521 O O   . PHE A 1 260 ? 22.22512  -18.52035 -22.41275 1.000 7.32532  ? 341  PHE A O   1 
ATOM   2522 C CB  . PHE A 1 260 ? 24.45760  -16.26656 -22.83615 1.000 7.68670  ? 341  PHE A CB  1 
ATOM   2523 C CG  . PHE A 1 260 ? 25.82774  -15.63505 -22.73822 1.000 8.16265  ? 341  PHE A CG  1 
ATOM   2524 C CD1 . PHE A 1 260 ? 26.98055  -16.38344 -22.93503 1.000 8.67353  ? 341  PHE A CD1 1 
ATOM   2525 C CD2 . PHE A 1 260 ? 25.95388  -14.28019 -22.48636 1.000 8.40271  ? 341  PHE A CD2 1 
ATOM   2526 C CE1 . PHE A 1 260 ? 28.23476  -15.80225 -22.84576 1.000 9.27480  ? 341  PHE A CE1 1 
ATOM   2527 C CE2 . PHE A 1 260 ? 27.20703  -13.68780 -22.41231 1.000 9.39956  ? 341  PHE A CE2 1 
ATOM   2528 C CZ  . PHE A 1 260 ? 28.34585  -14.45190 -22.59200 1.000 9.95097  ? 341  PHE A CZ  1 
ATOM   2529 N N   . ILE A 1 261 ? 21.80905  -16.63882 -21.23940 1.000 7.01003  ? 342  ILE A N   1 
ATOM   2530 C CA  . ILE A 1 261 ? 20.38127  -16.61052 -21.53599 1.000 7.09349  ? 342  ILE A CA  1 
ATOM   2531 C C   . ILE A 1 261 ? 20.03824  -15.20695 -22.00727 1.000 6.68770  ? 342  ILE A C   1 
ATOM   2532 O O   . ILE A 1 261 ? 20.65570  -14.22148 -21.58797 1.000 7.39639  ? 342  ILE A O   1 
ATOM   2533 C CB  . ILE A 1 261 ? 19.50004  -17.06977 -20.35058 1.000 6.49771  ? 342  ILE A CB  1 
ATOM   2534 C CG1 . ILE A 1 261 ? 19.64759  -16.15167 -19.13798 1.000 7.66226  ? 342  ILE A CG1 1 
ATOM   2535 C CG2 . ILE A 1 261 ? 19.83383  -18.50237 -19.99662 1.000 7.58409  ? 342  ILE A CG2 1 
ATOM   2536 C CD1 . ILE A 1 261 ? 18.73534  -16.52796 -17.98356 1.000 7.88756  ? 342  ILE A CD1 1 
ATOM   2537 N N   . VAL A 1 262 ? 19.07704  -15.11867 -22.92331 1.000 7.03071  ? 343  VAL A N   1 
ATOM   2538 C CA  . VAL A 1 262 ? 18.73757  -13.85522 -23.57260 1.000 7.20467  ? 343  VAL A CA  1 
ATOM   2539 C C   . VAL A 1 262 ? 17.24085  -13.60429 -23.44568 1.000 6.31096  ? 343  VAL A C   1 
ATOM   2540 O O   . VAL A 1 262 ? 16.43147  -14.40910 -23.92319 1.000 6.74891  ? 343  VAL A O   1 
ATOM   2541 C CB  . VAL A 1 262 ? 19.15691  -13.84071 -25.05216 1.000 7.47340  ? 343  VAL A CB  1 
ATOM   2542 C CG1 . VAL A 1 262 ? 18.88039  -12.47702 -25.65676 1.000 7.80165  ? 343  VAL A CG1 1 
ATOM   2543 C CG2 . VAL A 1 262 ? 20.62529  -14.17058 -25.19877 1.000 9.03546  ? 343  VAL A CG2 1 
ATOM   2544 N N   . ASP A 1 263 ? 16.87820  -12.47362 -22.83992 1.000 6.66340  ? 344  ASP A N   1 
ATOM   2545 C CA  . ASP A 1 263 ? 15.48211  -12.05894 -22.76797 1.000 7.04260  ? 344  ASP A CA  1 
ATOM   2546 C C   . ASP A 1 263 ? 15.02318  -11.66107 -24.16389 1.000 6.60640  ? 344  ASP A C   1 
ATOM   2547 O O   . ASP A 1 263 ? 15.67653  -10.85583 -24.83718 1.000 7.15106  ? 344  ASP A O   1 
ATOM   2548 C CB  . ASP A 1 263 ? 15.36667  -10.85912 -21.82078 1.000 7.24630  ? 344  ASP A CB  1 
ATOM   2549 C CG  . ASP A 1 263 ? 13.96182  -10.64263 -21.27055 1.000 6.84093  ? 344  ASP A CG  1 
ATOM   2550 O OD1 . ASP A 1 263 ? 12.99081  -11.26301 -21.76853 1.000 7.14787  ? 344  ASP A OD1 1 
ATOM   2551 O OD2 . ASP A 1 263 ? 13.84790  -9.83568  -20.31848 1.000 7.01339  ? 344  ASP A OD2 1 
ATOM   2552 N N   . GLN A 1 264 ? 13.90952  -12.24132 -24.60907 1.000 6.86045  ? 345  GLN A N   1 
ATOM   2553 C CA  . GLN A 1 264 ? 13.24303  -11.81563 -25.83436 1.000 8.12188  ? 345  GLN A CA  1 
ATOM   2554 C C   . GLN A 1 264 ? 11.77268  -11.48926 -25.59522 1.000 7.17221  ? 345  GLN A C   1 
ATOM   2555 O O   . GLN A 1 264 ? 11.01859  -11.31584 -26.56448 1.000 7.95565  ? 345  GLN A O   1 
ATOM   2556 C CB  . GLN A 1 264 ? 13.39380  -12.86432 -26.94543 1.000 7.17784  ? 345  GLN A CB  1 
ATOM   2557 C CG  . GLN A 1 264 ? 14.81804  -12.98522 -27.48904 1.000 8.56216  ? 345  GLN A CG  1 
ATOM   2558 C CD  . GLN A 1 264 ? 15.21122  -11.79605 -28.34819 1.000 7.49463  ? 345  GLN A CD  1 
ATOM   2559 O OE1 . GLN A 1 264 ? 14.86758  -11.73628 -29.53156 1.000 8.98538  ? 345  GLN A OE1 1 
ATOM   2560 N NE2 . GLN A 1 264 ? 15.92425  -10.84056 -27.75961 1.000 8.34748  ? 345  GLN A NE2 1 
ATOM   2561 N N   . GLY A 1 265 ? 11.35489  -11.37049 -24.33567 1.000 7.26182  ? 346  GLY A N   1 
ATOM   2562 C CA  . GLY A 1 265 ? 9.94906   -11.19120 -24.04442 1.000 7.70387  ? 346  GLY A CA  1 
ATOM   2563 C C   . GLY A 1 265 ? 9.34057   -9.92548  -24.60602 1.000 7.35558  ? 346  GLY A C   1 
ATOM   2564 O O   . GLY A 1 265 ? 8.11826   -9.87246  -24.78278 1.000 10.32255 ? 346  GLY A O   1 
ATOM   2565 N N   . LYS A 1 266 ? 10.14043  -8.89481  -24.86168 1.000 7.40243  ? 347  LYS A N   1 
ATOM   2566 C CA  . LYS A 1 266 ? 9.62701   -7.64370  -25.40171 1.000 7.73558  ? 347  LYS A CA  1 
ATOM   2567 C C   . LYS A 1 266 ? 10.31712  -7.26646  -26.70629 1.000 8.22588  ? 347  LYS A C   1 
ATOM   2568 O O   . LYS A 1 266 ? 10.39990  -6.08706  -27.04872 1.000 8.37561  ? 347  LYS A O   1 
ATOM   2569 C CB  . LYS A 1 266 ? 9.71880   -6.51753  -24.37241 1.000 9.37760  ? 347  LYS A CB  1 
ATOM   2570 C CG  . LYS A 1 266 ? 8.86345   -6.77717  -23.14406 1.000 8.96385  ? 347  LYS A CG  1 
ATOM   2571 C CD  . LYS A 1 266 ? 9.09663   -5.75895  -22.04541 1.000 12.67739 ? 347  LYS A CD  1 
ATOM   2572 C CE  . LYS A 1 266 ? 8.58374   -4.39758  -22.44757 1.000 10.99179 ? 347  LYS A CE  1 
ATOM   2573 N NZ  . LYS A 1 266 ? 8.74104   -3.40785  -21.34879 1.000 11.14374 ? 347  LYS A NZ  1 
ATOM   2574 N N   A SER A 1 267 ? 10.79969  -8.27010  -27.44102 0.804 7.80813  ? 348  SER A N   1 
ATOM   2575 N N   B SER A 1 267 ? 10.79695  -8.24757  -27.46285 0.196 7.86578  ? 348  SER A N   1 
ATOM   2576 C CA  A SER A 1 267 ? 11.63700  -8.07021  -28.61685 0.804 8.12349  ? 348  SER A CA  1 
ATOM   2577 C CA  B SER A 1 267 ? 11.55575  -7.96814  -28.67404 0.196 7.82345  ? 348  SER A CA  1 
ATOM   2578 C C   A SER A 1 267 ? 10.96340  -8.45346  -29.92933 0.804 7.64222  ? 348  SER A C   1 
ATOM   2579 C C   B SER A 1 267 ? 10.72967  -8.08410  -29.95584 0.196 7.19506  ? 348  SER A C   1 
ATOM   2580 O O   A SER A 1 267 ? 11.63705  -8.49284  -30.96835 0.804 7.92849  ? 348  SER A O   1 
ATOM   2581 O O   B SER A 1 267 ? 11.29316  -7.97829  -31.04928 0.196 5.64326  ? 348  SER A O   1 
ATOM   2582 C CB  A SER A 1 267 ? 12.94413  -8.84980  -28.45930 0.804 8.03245  ? 348  SER A CB  1 
ATOM   2583 C CB  B SER A 1 267 ? 12.79953  -8.86236  -28.73817 0.196 9.19552  ? 348  SER A CB  1 
ATOM   2584 O OG  A SER A 1 267 ? 13.73145  -8.28154  -27.43209 0.804 8.46955  ? 348  SER A OG  1 
ATOM   2585 O OG  B SER A 1 267 ? 13.60808  -8.70366  -27.57986 0.196 7.77056  ? 348  SER A OG  1 
ATOM   2586 N N   A GLY A 1 268 ? 9.65711   -8.72979  -29.91800 0.804 7.11069  ? 349  GLY A N   1 
ATOM   2587 N N   B GLY A 1 268 ? 9.40844   -8.25678  -29.84932 0.196 7.08042  ? 349  GLY A N   1 
ATOM   2588 C CA  A GLY A 1 268 ? 8.97864   -9.12979  -31.13508 0.804 7.36247  ? 349  GLY A CA  1 
ATOM   2589 C CA  B GLY A 1 268 ? 8.60723   -8.58755  -31.01945 0.196 6.21013  ? 349  GLY A CA  1 
ATOM   2590 C C   A GLY A 1 268 ? 8.92474   -8.05339  -32.19276 0.804 7.11551  ? 349  GLY A C   1 
ATOM   2591 C C   B GLY A 1 268 ? 8.50217   -7.48212  -32.05375 0.196 6.34631  ? 349  GLY A C   1 
ATOM   2592 O O   A GLY A 1 268 ? 8.76869   -8.37136  -33.37739 0.804 9.34794  ? 349  GLY A O   1 
ATOM   2593 O O   B GLY A 1 268 ? 8.35513   -7.76089  -33.24841 0.196 6.98526  ? 349  GLY A O   1 
ATOM   2594 N N   A VAL A 1 269 ? 9.03474   -6.78799  -31.79785 0.804 7.26353  ? 350  VAL A N   1 
ATOM   2595 N N   B VAL A 1 269 ? 8.55729   -6.22487  -31.62364 0.196 6.48005  ? 350  VAL A N   1 
ATOM   2596 C CA  A VAL A 1 269 ? 8.96669   -5.65521  -32.71439 0.804 7.85651  ? 350  VAL A CA  1 
ATOM   2597 C CA  B VAL A 1 269 ? 8.45136   -5.08338  -32.52569 0.196 6.48140  ? 350  VAL A CA  1 
ATOM   2598 C C   A VAL A 1 269 ? 10.27673  -4.88164  -32.61455 0.804 7.14110  ? 350  VAL A C   1 
ATOM   2599 C C   B VAL A 1 269 ? 9.74102   -4.28109  -32.42748 0.196 6.80268  ? 350  VAL A C   1 
ATOM   2600 O O   A VAL A 1 269 ? 10.58769  -4.29330  -31.56808 0.804 7.39560  ? 350  VAL A O   1 
ATOM   2601 O O   B VAL A 1 269 ? 10.09442  -3.79049  -31.34748 0.196 7.95958  ? 350  VAL A O   1 
ATOM   2602 C CB  A VAL A 1 269 ? 7.76339   -4.75266  -32.42218 0.804 7.80625  ? 350  VAL A CB  1 
ATOM   2603 C CB  B VAL A 1 269 ? 7.23102   -4.20875  -32.20121 0.196 7.32631  ? 350  VAL A CB  1 
ATOM   2604 C CG1 A VAL A 1 269 ? 7.68077   -3.66317  -33.45676 0.804 8.64462  ? 350  VAL A CG1 1 
ATOM   2605 C CG1 B VAL A 1 269 ? 7.12705   -3.05716  -33.18919 0.196 7.63558  ? 350  VAL A CG1 1 
ATOM   2606 C CG2 A VAL A 1 269 ? 6.48135   -5.57374  -32.42576 0.804 8.75180  ? 350  VAL A CG2 1 
ATOM   2607 C CG2 B VAL A 1 269 ? 5.96552   -5.04413  -32.21170 0.196 5.63762  ? 350  VAL A CG2 1 
ATOM   2608 N N   A GLN A 1 270 ? 11.04308  -4.88559  -33.69990 0.804 7.96852  ? 351  GLN A N   1 
ATOM   2609 N N   B GLN A 1 270 ? 10.44051  -4.15383  -33.54999 0.196 5.94766  ? 351  GLN A N   1 
ATOM   2610 C CA  A GLN A 1 270 ? 12.30723  -4.17599  -33.80311 0.804 8.44727  ? 351  GLN A CA  1 
ATOM   2611 C CA  B GLN A 1 270 ? 11.67506  -3.39549  -33.64241 0.196 7.35125  ? 351  GLN A CA  1 
ATOM   2612 C C   A GLN A 1 270 ? 12.09410  -2.82799  -34.48525 0.804 7.68348  ? 351  GLN A C   1 
ATOM   2613 C C   B GLN A 1 270 ? 11.38556  -2.01622  -34.22903 0.196 7.38787  ? 351  GLN A C   1 
ATOM   2614 O O   A GLN A 1 270 ? 11.01967  -2.53376  -35.02105 0.804 8.32094  ? 351  GLN A O   1 
ATOM   2615 O O   B GLN A 1 270 ? 10.26026  -1.70592  -34.62525 0.196 7.33159  ? 351  GLN A O   1 
ATOM   2616 C CB  A GLN A 1 270 ? 13.28550  -5.04121  -34.59822 0.804 8.13197  ? 351  GLN A CB  1 
ATOM   2617 C CB  B GLN A 1 270 ? 12.69233  -4.16283  -34.48857 0.196 8.33293  ? 351  GLN A CB  1 
ATOM   2618 C CG  A GLN A 1 270 ? 13.69402  -6.28496  -33.84551 0.804 8.89620  ? 351  GLN A CG  1 
ATOM   2619 C CG  B GLN A 1 270 ? 13.06485  -5.51319  -33.90317 0.196 9.53908  ? 351  GLN A CG  1 
ATOM   2620 C CD  A GLN A 1 270 ? 14.32597  -5.92998  -32.51996 0.804 7.45859  ? 351  GLN A CD  1 
ATOM   2621 C CD  B GLN A 1 270 ? 13.87272  -5.38694  -32.62823 0.196 6.92893  ? 351  GLN A CD  1 
ATOM   2622 O OE1 A GLN A 1 270 ? 15.28812  -5.16296  -32.48130 0.804 7.89968  ? 351  GLN A OE1 1 
ATOM   2623 O OE1 B GLN A 1 270 ? 14.75618  -4.53678  -32.52578 0.196 7.78679  ? 351  GLN A OE1 1 
ATOM   2624 N NE2 A GLN A 1 270 ? 13.78842  -6.46756  -31.42747 0.804 8.31324  ? 351  GLN A NE2 1 
ATOM   2625 N NE2 B GLN A 1 270 ? 13.55939  -6.21697  -31.63992 0.196 9.87575  ? 351  GLN A NE2 1 
ATOM   2626 N N   A ASN A 1 271 ? 13.12854  -1.98734  -34.43663 0.804 6.84012  ? 352  ASN A N   1 
ATOM   2627 N N   B ASN A 1 271 ? 12.42264  -1.17984  -34.28597 0.196 6.63837  ? 352  ASN A N   1 
ATOM   2628 C CA  A ASN A 1 271 ? 13.15263  -0.74255  -35.20952 0.804 7.93634  ? 352  ASN A CA  1 
ATOM   2629 C CA  B ASN A 1 271 ? 12.31966  0.17332   -34.83719 0.196 8.26556  ? 352  ASN A CA  1 
ATOM   2630 C C   A ASN A 1 271 ? 12.04421  0.21860   -34.78820 0.804 7.78757  ? 352  ASN A C   1 
ATOM   2631 C C   B ASN A 1 271 ? 11.25984  1.00882   -34.11518 0.196 8.98588  ? 352  ASN A C   1 
ATOM   2632 O O   A ASN A 1 271 ? 11.41299  0.87134   -35.62622 0.804 8.44127  ? 352  ASN A O   1 
ATOM   2633 O O   B ASN A 1 271 ? 10.44474  1.69534   -34.73463 0.196 10.15069 ? 352  ASN A O   1 
ATOM   2634 C CB  A ASN A 1 271 ? 13.10672  -1.00419  -36.71766 0.804 8.07476  ? 352  ASN A CB  1 
ATOM   2635 C CB  B ASN A 1 271 ? 12.11141  0.16862   -36.35478 0.196 9.65737  ? 352  ASN A CB  1 
ATOM   2636 C CG  A ASN A 1 271 ? 14.11816  -2.03691  -37.16318 0.804 8.37254  ? 352  ASN A CG  1 
ATOM   2637 C CG  B ASN A 1 271 ? 13.23499  -0.53029  -37.09582 0.196 11.09939 ? 352  ASN A CG  1 
ATOM   2638 O OD1 A ASN A 1 271 ? 15.17624  -2.19074  -36.55672 0.804 9.47990  ? 352  ASN A OD1 1 
ATOM   2639 O OD1 B ASN A 1 271 ? 13.10149  -0.86653  -38.27179 0.196 14.04360 ? 352  ASN A OD1 1 
ATOM   2640 N ND2 A ASN A 1 271 ? 13.79934  -2.74823  -38.24103 0.804 11.01585 ? 352  ASN A ND2 1 
ATOM   2641 N ND2 B ASN A 1 271 ? 14.35174  -0.75142  -36.41123 0.196 10.73014 ? 352  ASN A ND2 1 
ATOM   2642 N N   A ILE A 1 272 ? 11.82042  0.32989   -33.47702 0.804 7.82505  ? 353  ILE A N   1 
ATOM   2643 N N   B ILE A 1 272 ? 11.28420  0.95190   -32.78371 0.196 7.46772  ? 353  ILE A N   1 
ATOM   2644 C CA  A ILE A 1 272 ? 10.76977  1.18701   -32.94275 0.804 7.79392  ? 353  ILE A CA  1 
ATOM   2645 C CA  B ILE A 1 272 ? 10.33662  1.67688   -31.94609 0.196 5.70112  ? 353  ILE A CA  1 
ATOM   2646 C C   A ILE A 1 272 ? 11.28192  2.22823   -31.95530 0.804 7.74409  ? 353  ILE A C   1 
ATOM   2647 C C   B ILE A 1 272 ? 10.99319  2.71035   -31.04252 0.196 9.86218  ? 353  ILE A C   1 
ATOM   2648 O O   A ILE A 1 272 ? 10.48258  2.93072   -31.33672 0.804 12.54526 ? 353  ILE A O   1 
ATOM   2649 O O   B ILE A 1 272 ? 10.28883  3.39823   -30.29688 0.196 10.10984 ? 353  ILE A O   1 
ATOM   2650 C CB  A ILE A 1 272 ? 9.58809   0.38428   -32.36543 0.804 7.36684  ? 353  ILE A CB  1 
ATOM   2651 C CB  B ILE A 1 272 ? 9.41726   0.73212   -31.14478 0.196 7.42140  ? 353  ILE A CB  1 
ATOM   2652 C CG1 A ILE A 1 272 ? 10.06868  -0.64666  -31.34227 0.804 9.27555  ? 353  ILE A CG1 1 
ATOM   2653 C CG1 B ILE A 1 272 ? 10.24492  -0.19614  -30.25039 0.196 8.97825  ? 353  ILE A CG1 1 
ATOM   2654 C CG2 A ILE A 1 272 ? 8.81441   -0.26237  -33.48827 0.804 8.76196  ? 353  ILE A CG2 1 
ATOM   2655 C CG2 B ILE A 1 272 ? 8.53157   -0.04808  -32.08627 0.196 10.21650 ? 353  ILE A CG2 1 
ATOM   2656 C CD1 A ILE A 1 272 ? 8.94099   -1.21794  -30.51391 0.804 9.89140  ? 353  ILE A CD1 1 
ATOM   2657 C CD1 B ILE A 1 272 ? 9.41564   -1.05674  -29.31293 0.196 8.03602  ? 353  ILE A CD1 1 
ATOM   2658 N N   A ARG A 1 273 ? 12.59079  2.36912   -31.80180 0.804 8.04985  ? 354  ARG A N   1 
ATOM   2659 N N   B ARG A 1 273 ? 12.31414  2.85942   -31.10183 0.196 10.36774 ? 354  ARG A N   1 
ATOM   2660 C CA  A ARG A 1 273 ? 13.13989  3.34078   -30.87258 0.804 7.51058  ? 354  ARG A CA  1 
ATOM   2661 C CA  B ARG A 1 273 ? 13.03091  3.85925   -30.32557 0.196 9.43852  ? 354  ARG A CA  1 
ATOM   2662 C C   A ARG A 1 273 ? 13.79545  4.48593   -31.61836 0.804 7.39978  ? 354  ARG A C   1 
ATOM   2663 C C   B ARG A 1 273 ? 13.75707  4.82969   -31.24686 0.196 10.78439 ? 354  ARG A C   1 
ATOM   2664 O O   A ARG A 1 273 ? 14.42724  4.28997   -32.66214 0.804 8.71012  ? 354  ARG A O   1 
ATOM   2665 O O   B ARG A 1 273 ? 14.23748  4.45334   -32.32015 0.196 10.78718 ? 354  ARG A O   1 
ATOM   2666 C CB  A ARG A 1 273 ? 14.17016  2.70246   -29.94900 0.804 7.17651  ? 354  ARG A CB  1 
ATOM   2667 C CB  B ARG A 1 273 ? 14.05544  3.21234   -29.38185 0.196 10.00888 ? 354  ARG A CB  1 
ATOM   2668 C CG  A ARG A 1 273 ? 13.51301  1.91454   -28.85882 0.804 7.24418  ? 354  ARG A CG  1 
ATOM   2669 C CG  B ARG A 1 273 ? 13.47753  2.75862   -28.05322 0.196 11.93335 ? 354  ARG A CG  1 
ATOM   2670 C CD  A ARG A 1 273 ? 14.53105  1.23621   -28.01093 0.804 7.66001  ? 354  ARG A CD  1 
ATOM   2671 C CD  B ARG A 1 273 ? 13.33639  1.25076   -27.95236 0.196 13.74133 ? 354  ARG A CD  1 
ATOM   2672 N NE  A ARG A 1 273 ? 15.10015  0.05969   -28.65066 0.804 6.21570  ? 354  ARG A NE  1 
ATOM   2673 N NE  B ARG A 1 273 ? 14.43090  0.52928   -28.58831 0.196 13.65319 ? 354  ARG A NE  1 
ATOM   2674 C CZ  A ARG A 1 273 ? 15.91133  -0.76700  -28.01315 0.804 6.41967  ? 354  ARG A CZ  1 
ATOM   2675 C CZ  B ARG A 1 273 ? 15.29897  -0.23415  -27.93877 0.196 10.81945 ? 354  ARG A CZ  1 
ATOM   2676 N NH1 A ARG A 1 273 ? 16.31496  -0.51052  -26.77731 0.804 8.62769  ? 354  ARG A NH1 1 
ATOM   2677 N NH1 B ARG A 1 273 ? 15.29874  -0.31184  -26.61858 0.196 13.98291 ? 354  ARG A NH1 1 
ATOM   2678 N NH2 A ARG A 1 273 ? 16.31374  -1.87819  -28.61719 0.804 7.60397  ? 354  ARG A NH2 1 
ATOM   2679 N NH2 B ARG A 1 273 ? 16.19044  -0.93665  -28.63077 0.196 10.65819 ? 354  ARG A NH2 1 
ATOM   2680 N N   A GLN A 1 274 ? 13.67095  5.67998   -31.04517 0.804 7.85391  ? 355  GLN A N   1 
ATOM   2681 N N   B GLN A 1 274 ? 13.83981  6.08814   -30.81096 0.196 11.16247 ? 355  GLN A N   1 
ATOM   2682 C CA  A GLN A 1 274 ? 14.40911  6.82404   -31.55915 0.804 8.17594  ? 355  GLN A CA  1 
ATOM   2683 C CA  B GLN A 1 274 ? 14.65952  7.06941   -31.51007 0.196 10.27508 ? 355  GLN A CA  1 
ATOM   2684 C C   A GLN A 1 274 ? 15.90313  6.67400   -31.31447 0.804 7.84448  ? 355  GLN A C   1 
ATOM   2685 C C   B GLN A 1 274 ? 16.11612  7.01966   -31.07537 0.196 9.76276  ? 355  GLN A C   1 
ATOM   2686 O O   A GLN A 1 274 ? 16.71942  7.01640   -32.17702 0.804 8.00382  ? 355  GLN A O   1 
ATOM   2687 O O   B GLN A 1 274 ? 16.97715  7.57252   -31.76798 0.196 12.30765 ? 355  GLN A O   1 
ATOM   2688 C CB  A GLN A 1 274 ? 13.91236  8.10094   -30.89064 0.804 9.24644  ? 355  GLN A CB  1 
ATOM   2689 C CB  B GLN A 1 274 ? 14.11857  8.48162   -31.27752 0.196 13.01003 ? 355  GLN A CB  1 
ATOM   2690 C CG  A GLN A 1 274 ? 12.50280  8.47791   -31.26223 0.804 9.77995  ? 355  GLN A CG  1 
ATOM   2691 C CG  B GLN A 1 274 ? 12.60557  8.57060   -31.14189 0.196 10.34434 ? 355  GLN A CG  1 
ATOM   2692 C CD  A GLN A 1 274 ? 12.15234  9.87713   -30.79846 0.804 10.25994 ? 355  GLN A CD  1 
ATOM   2693 C CD  B GLN A 1 274 ? 12.14258  9.94186   -30.67664 0.196 10.56908 ? 355  GLN A CD  1 
ATOM   2694 O OE1 A GLN A 1 274 ? 12.46000  10.27212  -29.66896 0.804 11.84739 ? 355  GLN A OE1 1 
ATOM   2695 O OE1 B GLN A 1 274 ? 12.73673  10.53818  -29.77741 0.196 12.53029 ? 355  GLN A OE1 1 
ATOM   2696 N NE2 A GLN A 1 274 ? 11.52782  10.64609  -31.67689 0.804 11.67816 ? 355  GLN A NE2 1 
ATOM   2697 N NE2 B GLN A 1 274 ? 11.07734  10.44817  -31.28937 0.196 13.08719 ? 355  GLN A NE2 1 
ATOM   2698 N N   A GLN A 1 275 ? 16.27678  6.21301   -30.12680 0.804 8.04154  ? 356  GLN A N   1 
ATOM   2699 N N   B GLN A 1 275 ? 16.40297  6.38074   -29.94483 0.196 9.49808  ? 356  GLN A N   1 
ATOM   2700 C CA  A GLN A 1 275 ? 17.66985  6.12596   -29.72294 0.804 7.85302  ? 356  GLN A CA  1 
ATOM   2701 C CA  B GLN A 1 275 ? 17.74367  6.31375   -29.38503 0.196 9.66568  ? 356  GLN A CA  1 
ATOM   2702 C C   A GLN A 1 275 ? 17.84073  4.85645   -28.90460 0.804 8.07987  ? 356  GLN A C   1 
ATOM   2703 C C   B GLN A 1 275 ? 17.89279  4.94815   -28.73264 0.196 8.94668  ? 356  GLN A C   1 
ATOM   2704 O O   A GLN A 1 275 ? 16.90704  4.40371   -28.23709 0.804 8.07963  ? 356  GLN A O   1 
ATOM   2705 O O   B GLN A 1 275 ? 16.96847  4.48768   -28.05722 0.196 7.84725  ? 356  GLN A O   1 
ATOM   2706 C CB  A GLN A 1 275 ? 18.07330  7.33695   -28.86672 0.804 10.48384 ? 356  GLN A CB  1 
ATOM   2707 C CB  B GLN A 1 275 ? 17.92545  7.40678   -28.32233 0.196 8.09648  ? 356  GLN A CB  1 
ATOM   2708 C CG  A GLN A 1 275 ? 17.73537  8.69598   -29.47858 0.804 12.77116 ? 356  GLN A CG  1 
ATOM   2709 C CG  B GLN A 1 275 ? 17.80656  8.82967   -28.85274 0.196 13.28048 ? 356  GLN A CG  1 
ATOM   2710 C CD  A GLN A 1 275 ? 18.09850  9.85871   -28.57066 0.804 12.27909 ? 356  GLN A CD  1 
ATOM   2711 C CD  B GLN A 1 275 ? 17.18184  9.77960   -27.84841 0.196 14.75515 ? 356  GLN A CD  1 
ATOM   2712 O OE1 A GLN A 1 275 ? 19.26119  10.24438  -28.46907 0.804 14.57639 ? 356  GLN A OE1 1 
ATOM   2713 O OE1 B GLN A 1 275 ? 16.49591  10.73280  -28.22240 0.196 17.00146 ? 356  GLN A OE1 1 
ATOM   2714 N NE2 A GLN A 1 275 ? 17.10007  10.41445  -27.89287 0.804 14.93819 ? 356  GLN A NE2 1 
ATOM   2715 N NE2 B GLN A 1 275 ? 17.41593  9.52482   -26.56593 0.196 7.90298  ? 356  GLN A NE2 1 
ATOM   2716 N N   . TRP A 1 276 ? 19.04863  4.30031   -28.93766 1.000 8.03925  ? 357  TRP A N   1 
ATOM   2717 C CA  . TRP A 1 276 ? 19.26421  2.98591   -28.33077 1.000 7.93435  ? 357  TRP A CA  1 
ATOM   2718 C C   . TRP A 1 276 ? 19.04861  3.01271   -26.82650 1.000 7.45357  ? 357  TRP A C   1 
ATOM   2719 O O   . TRP A 1 276 ? 18.54233  2.04097   -26.24729 1.000 8.79944  ? 357  TRP A O   1 
ATOM   2720 C CB  . TRP A 1 276 ? 20.65518  2.44954   -28.65434 1.000 8.43021  ? 357  TRP A CB  1 
ATOM   2721 C CG  . TRP A 1 276 ? 20.73911  0.93593   -28.70069 1.000 7.49766  ? 357  TRP A CG  1 
ATOM   2722 C CD1 . TRP A 1 276 ? 19.80201  0.02320   -28.27998 1.000 7.75494  ? 357  TRP A CD1 1 
ATOM   2723 C CD2 . TRP A 1 276 ? 21.82956  0.18440   -29.21133 1.000 7.26253  ? 357  TRP A CD2 1 
ATOM   2724 N NE1 . TRP A 1 276 ? 20.25582  -1.25460  -28.50399 1.000 8.34723  ? 357  TRP A NE1 1 
ATOM   2725 C CE2 . TRP A 1 276 ? 21.49962  -1.18124  -29.08286 1.000 8.32007  ? 357  TRP A CE2 1 
ATOM   2726 C CE3 . TRP A 1 276 ? 23.06096  0.53452   -29.77063 1.000 8.13987  ? 357  TRP A CE3 1 
ATOM   2727 C CZ2 . TRP A 1 276 ? 22.36426  -2.19772  -29.49803 1.000 8.51371  ? 357  TRP A CZ2 1 
ATOM   2728 C CZ3 . TRP A 1 276 ? 23.91279  -0.46950  -30.18026 1.000 8.44851  ? 357  TRP A CZ3 1 
ATOM   2729 C CH2 . TRP A 1 276 ? 23.56738  -1.82044  -30.03790 1.000 8.01464  ? 357  TRP A CH2 1 
ATOM   2730 N N   . GLY A 1 277 ? 19.41161  4.11933   -26.18081 1.000 7.96825  ? 358  GLY A N   1 
ATOM   2731 C CA  . GLY A 1 277 ? 19.28523  4.26810   -24.74865 1.000 8.26245  ? 358  GLY A CA  1 
ATOM   2732 C C   . GLY A 1 277 ? 17.87208  4.48287   -24.23183 1.000 8.19413  ? 358  GLY A C   1 
ATOM   2733 O O   . GLY A 1 277 ? 17.70220  4.67264   -23.02459 1.000 8.87957  ? 358  GLY A O   1 
ATOM   2734 N N   A ASP A 1 278 ? 16.86479  4.47062   -25.10821 0.908 7.86704  ? 359  ASP A N   1 
ATOM   2735 N N   B ASP A 1 278 ? 16.84796  4.45787   -25.07689 0.092 7.94624  ? 359  ASP A N   1 
ATOM   2736 C CA  A ASP A 1 278 ? 15.46816  4.57979   -24.68723 0.908 8.08664  ? 359  ASP A CA  1 
ATOM   2737 C CA  B ASP A 1 278 ? 15.47875  4.64155   -24.60511 0.092 8.17181  ? 359  ASP A CA  1 
ATOM   2738 C C   A ASP A 1 278 ? 15.02968  3.20327   -24.19915 0.908 8.19228  ? 359  ASP A C   1 
ATOM   2739 C C   B ASP A 1 278 ? 14.89931  3.29274   -24.18833 0.092 8.41720  ? 359  ASP A C   1 
ATOM   2740 O O   A ASP A 1 278 ? 14.76209  2.30627   -25.00324 0.908 11.31372 ? 359  ASP A O   1 
ATOM   2741 O O   B ASP A 1 278 ? 14.80973  2.37280   -25.00866 0.092 10.94896 ? 359  ASP A O   1 
ATOM   2742 C CB  A ASP A 1 278 ? 14.57943  5.05227   -25.83624 0.908 8.54755  ? 359  ASP A CB  1 
ATOM   2743 C CB  B ASP A 1 278 ? 14.61403  5.30235   -25.67721 0.092 8.62445  ? 359  ASP A CB  1 
ATOM   2744 C CG  A ASP A 1 278 ? 15.06082  6.35005   -26.47678 0.908 8.08501  ? 359  ASP A CG  1 
ATOM   2745 C CG  B ASP A 1 278 ? 15.07764  6.70717   -26.01735 0.092 8.61275  ? 359  ASP A CG  1 
ATOM   2746 O OD1 A ASP A 1 278 ? 15.91025  7.05236   -25.89550 0.908 10.06167 ? 359  ASP A OD1 1 
ATOM   2747 O OD1 B ASP A 1 278 ? 15.88081  7.27498   -25.24520 0.092 7.36714  ? 359  ASP A OD1 1 
ATOM   2748 O OD2 A ASP A 1 278 ? 14.54312  6.71510   -27.55380 0.908 9.10658  ? 359  ASP A OD2 1 
ATOM   2749 O OD2 B ASP A 1 278 ? 14.62933  7.24813   -27.05022 0.092 7.09887  ? 359  ASP A OD2 1 
ATOM   2750 N N   A TRP A 1 279 ? 14.95452  3.02995   -22.87395 0.908 7.40151  ? 360  TRP A N   1 
ATOM   2751 N N   B TRP A 1 279 ? 14.49838  3.17652   -22.91740 0.092 8.30493  ? 360  TRP A N   1 
ATOM   2752 C CA  A TRP A 1 279 ? 14.63361  1.73747   -22.27677 0.908 7.33264  ? 360  TRP A CA  1 
ATOM   2753 C CA  B TRP A 1 279 ? 14.04075  1.88958   -22.39901 0.092 9.09050  ? 360  TRP A CA  1 
ATOM   2754 C C   A TRP A 1 279 ? 13.25546  1.67701   -21.63382 0.908 6.97739  ? 360  TRP A C   1 
ATOM   2755 C C   B TRP A 1 279 ? 12.71104  1.94772   -21.64835 0.092 8.39120  ? 360  TRP A C   1 
ATOM   2756 O O   A TRP A 1 279 ? 12.86004  0.60744   -21.15730 0.908 8.05246  ? 360  TRP A O   1 
ATOM   2757 O O   B TRP A 1 279 ? 11.98912  0.94666   -21.60560 0.092 10.60610 ? 360  TRP A O   1 
ATOM   2758 C CB  A TRP A 1 279 ? 15.68115  1.34122   -21.21222 0.908 9.12301  ? 360  TRP A CB  1 
ATOM   2759 C CB  B TRP A 1 279 ? 15.11233  1.23950   -21.51431 0.092 9.01038  ? 360  TRP A CB  1 
ATOM   2760 C CG  A TRP A 1 279 ? 15.97514  2.42930   -20.20753 0.908 7.95851  ? 360  TRP A CG  1 
ATOM   2761 C CG  B TRP A 1 279 ? 15.86935  2.20041   -20.64728 0.092 8.35958  ? 360  TRP A CG  1 
ATOM   2762 C CD1 A TRP A 1 279 ? 17.02350  3.29359   -20.23646 0.908 8.19044  ? 360  TRP A CD1 1 
ATOM   2763 C CD1 B TRP A 1 279 ? 17.07761  2.76972   -20.91769 0.092 8.93873  ? 360  TRP A CD1 1 
ATOM   2764 C CD2 A TRP A 1 279 ? 15.20272  2.77333   -19.04241 0.908 8.51477  ? 360  TRP A CD2 1 
ATOM   2765 C CD2 B TRP A 1 279 ? 15.47252  2.69531   -19.36152 0.092 9.27026  ? 360  TRP A CD2 1 
ATOM   2766 N NE1 A TRP A 1 279 ? 16.95867  4.15192   -19.17620 0.908 8.83841  ? 360  TRP A NE1 1 
ATOM   2767 N NE1 B TRP A 1 279 ? 17.45464  3.59602   -19.88725 0.092 9.38139  ? 360  TRP A NE1 1 
ATOM   2768 C CE2 A TRP A 1 279 ? 15.84698  3.86257   -18.42867 0.908 8.45013  ? 360  TRP A CE2 1 
ATOM   2769 C CE2 B TRP A 1 279 ? 16.48776  3.56584   -18.91787 0.092 10.01428 ? 360  TRP A CE2 1 
ATOM   2770 C CE3 A TRP A 1 279 ? 14.03775  2.26059   -18.45743 0.908 7.84884  ? 360  TRP A CE3 1 
ATOM   2771 C CE3 B TRP A 1 279 ? 14.35698  2.48848   -18.54424 0.092 9.31570  ? 360  TRP A CE3 1 
ATOM   2772 C CZ2 A TRP A 1 279 ? 15.36644  4.45768   -17.26610 0.908 10.26360 ? 360  TRP A CZ2 1 
ATOM   2773 C CZ2 B TRP A 1 279 ? 16.42080  4.22925   -17.69490 0.092 11.60700 ? 360  TRP A CZ2 1 
ATOM   2774 C CZ3 A TRP A 1 279 ? 13.55256  2.86387   -17.30387 0.908 7.66730  ? 360  TRP A CZ3 1 
ATOM   2775 C CZ3 B TRP A 1 279 ? 14.29235  3.14860   -17.33038 0.092 10.28358 ? 360  TRP A CZ3 1 
ATOM   2776 C CH2 A TRP A 1 279 ? 14.21776  3.95041   -16.72175 0.908 9.96923  ? 360  TRP A CH2 1 
ATOM   2777 C CH2 B TRP A 1 279 ? 15.31781  4.00796   -16.91779 0.092 11.52382 ? 360  TRP A CH2 1 
ATOM   2778 N N   A CYS A 1 280 ? 12.52809  2.77935   -21.56053 0.908 7.37139  ? 361  CYS A N   1 
ATOM   2779 N N   B CYS A 1 280 ? 12.37215  3.09041   -21.04934 0.092 8.33218  ? 361  CYS A N   1 
ATOM   2780 C CA  A CYS A 1 280 ? 11.35069  2.84364   -20.70293 0.908 7.80348  ? 361  CYS A CA  1 
ATOM   2781 C CA  B CYS A 1 280 ? 11.20492  3.15948   -20.16805 0.092 8.05725  ? 361  CYS A CA  1 
ATOM   2782 C C   A CYS A 1 280 ? 10.05088  2.74489   -21.49933 0.908 6.68646  ? 361  CYS A C   1 
ATOM   2783 C C   B CYS A 1 280 ? 9.91337   3.06661   -20.97458 0.092 7.23125  ? 361  CYS A C   1 
ATOM   2784 O O   A CYS A 1 280 ? 9.71032   3.65196   -22.26814 0.908 7.83231  ? 361  CYS A O   1 
ATOM   2785 O O   B CYS A 1 280 ? 9.54150   4.01449   -21.67471 0.092 6.23400  ? 361  CYS A O   1 
ATOM   2786 C CB  A CYS A 1 280 ? 11.37313  4.11090   -19.86037 0.908 8.22300  ? 361  CYS A CB  1 
ATOM   2787 C CB  B CYS A 1 280 ? 11.22683  4.43181   -19.32527 0.092 9.12667  ? 361  CYS A CB  1 
ATOM   2788 S SG  A CYS A 1 280 ? 10.08101  4.05823   -18.61770 0.908 7.73090  ? 361  CYS A SG  1 
ATOM   2789 S SG  B CYS A 1 280 ? 9.80031   4.56691   -18.19613 0.092 7.16989  ? 361  CYS A SG  1 
ATOM   2790 N N   A ASN A 1 281 ? 9.30608   1.66072   -21.27563 0.908 7.03614  ? 362  ASN A N   1 
ATOM   2791 N N   B ASN A 1 281 ? 9.22633   1.92549   -20.85527 0.092 7.01568  ? 362  ASN A N   1 
ATOM   2792 C CA  A ASN A 1 281 ? 7.93481   1.50439   -21.78119 0.908 7.97535  ? 362  ASN A CA  1 
ATOM   2793 C CA  B ASN A 1 281 ? 7.91391   1.67960   -21.45076 0.092 8.16054  ? 362  ASN A CA  1 
ATOM   2794 C C   A ASN A 1 281 ? 7.82139   1.82932   -23.27003 0.908 7.75425  ? 362  ASN A C   1 
ATOM   2795 C C   B ASN A 1 281 ? 7.79601   2.17883   -22.88591 0.092 8.24196  ? 362  ASN A C   1 
ATOM   2796 O O   A ASN A 1 281 ? 6.97219   2.61469   -23.68976 0.908 7.78186  ? 362  ASN A O   1 
ATOM   2797 O O   B ASN A 1 281 ? 7.00974   3.09031   -23.16484 0.092 8.57195  ? 362  ASN A O   1 
ATOM   2798 C CB  A ASN A 1 281 ? 6.94382   2.34495   -20.97691 0.908 7.83684  ? 362  ASN A CB  1 
ATOM   2799 C CB  B ASN A 1 281 ? 6.80213   2.28787   -20.58929 0.092 9.27864  ? 362  ASN A CB  1 
ATOM   2800 C CG  A ASN A 1 281 ? 6.93291   1.99293   -19.49991 0.908 7.53202  ? 362  ASN A CG  1 
ATOM   2801 C CG  B ASN A 1 281 ? 6.73972   1.68095   -19.20050 0.092 9.51126  ? 362  ASN A CG  1 
ATOM   2802 O OD1 A ASN A 1 281 ? 6.97691   0.82422   -19.11457 0.908 7.73688  ? 362  ASN A OD1 1 
ATOM   2803 O OD1 B ASN A 1 281 ? 5.99138   0.73505   -18.95745 0.092 10.18171 ? 362  ASN A OD1 1 
ATOM   2804 N ND2 A ASN A 1 281 ? 6.86927   3.00995   -18.66122 0.908 7.90102  ? 362  ASN A ND2 1 
ATOM   2805 N ND2 B ASN A 1 281 ? 7.51145   2.23791   -18.27578 0.092 9.68766  ? 362  ASN A ND2 1 
ATOM   2806 N N   A ILE A 1 282 ? 8.66833   1.19502   -24.08076 0.908 7.93658  ? 363  ILE A N   1 
ATOM   2807 N N   B ILE A 1 282 ? 8.55907   1.58515   -23.80181 0.092 7.07282  ? 363  ILE A N   1 
ATOM   2808 C CA  A ILE A 1 282 ? 8.75645   1.55195   -25.49508 0.908 8.01636  ? 363  ILE A CA  1 
ATOM   2809 C CA  B ILE A 1 282 ? 8.54832   2.03256   -25.19118 0.092 7.24217  ? 363  ILE A CA  1 
ATOM   2810 C C   A ILE A 1 282 ? 7.45632   1.21662   -26.21536 0.908 7.94940  ? 363  ILE A C   1 
ATOM   2811 C C   B ILE A 1 282 ? 7.20816   1.67919   -25.81935 0.092 7.60008  ? 363  ILE A C   1 
ATOM   2812 O O   A ILE A 1 282 ? 6.98144   0.07343   -26.18589 0.908 8.80050  ? 363  ILE A O   1 
ATOM   2813 O O   B ILE A 1 282 ? 6.83144   0.50376   -25.89340 0.092 8.47806  ? 363  ILE A O   1 
ATOM   2814 C CB  A ILE A 1 282 ? 9.97986   0.89140   -26.14880 0.908 9.28925  ? 363  ILE A CB  1 
ATOM   2815 C CB  B ILE A 1 282 ? 9.70946   1.42017   -25.98377 0.092 6.20550  ? 363  ILE A CB  1 
ATOM   2816 C CG1 A ILE A 1 282 ? 11.27129  1.39356   -25.49144 0.908 9.97246  ? 363  ILE A CG1 1 
ATOM   2817 C CG1 B ILE A 1 282 ? 11.04415  1.70117   -25.29968 0.092 9.09924  ? 363  ILE A CG1 1 
ATOM   2818 C CG2 A ILE A 1 282 ? 9.98864   1.16147   -27.64966 0.908 10.43401 ? 363  ILE A CG2 1 
ATOM   2819 C CG2 B ILE A 1 282 ? 9.73553   1.99259   -27.38757 0.092 8.10633  ? 363  ILE A CG2 1 
ATOM   2820 C CD1 A ILE A 1 282 ? 11.44542  2.89986   -25.55361 0.908 11.18761 ? 363  ILE A CD1 1 
ATOM   2821 C CD1 B ILE A 1 282 ? 11.16828  3.08668   -24.77376 0.092 10.38127 ? 363  ILE A CD1 1 
ATOM   2822 N N   A LYS A 1 283 ? 6.89358   2.21714   -26.89202 0.908 8.01779  ? 364  LYS A N   1 
ATOM   2823 N N   B LYS A 1 283 ? 6.48875   2.69863   -26.28031 0.092 8.13163  ? 364  LYS A N   1 
ATOM   2824 C CA  A LYS A 1 283 ? 5.56825   2.10993   -27.49031 0.908 10.07709 ? 364  LYS A CA  1 
ATOM   2825 C CA  B LYS A 1 283 ? 5.21252   2.48374   -26.94556 0.092 10.31437 ? 364  LYS A CA  1 
ATOM   2826 C C   A LYS A 1 283 ? 5.59323   1.20144   -28.70867 0.908 8.68210  ? 364  LYS A C   1 
ATOM   2827 C C   B LYS A 1 283 ? 5.38400   1.55982   -28.14665 0.092 9.48755  ? 364  LYS A C   1 
ATOM   2828 O O   A LYS A 1 283 ? 6.46238   1.32157   -29.57253 0.908 9.73350  ? 364  LYS A O   1 
ATOM   2829 O O   B LYS A 1 283 ? 6.37144   1.64147   -28.88248 0.092 9.80492  ? 364  LYS A O   1 
ATOM   2830 C CB  A LYS A 1 283 ? 5.10468   3.49034   -27.96390 0.908 12.10415 ? 364  LYS A CB  1 
ATOM   2831 C CB  B LYS A 1 283 ? 4.65235   3.83150   -27.40069 0.092 12.41167 ? 364  LYS A CB  1 
ATOM   2832 C CG  A LYS A 1 283 ? 4.53202   4.39105   -26.90673 0.908 15.90399 ? 364  LYS A CG  1 
ATOM   2833 C CG  B LYS A 1 283 ? 5.54265   4.55046   -28.40782 0.092 11.00952 ? 364  LYS A CG  1 
ATOM   2834 C CD  A LYS A 1 283 ? 3.66775   5.48219   -27.53207 0.908 20.97101 ? 364  LYS A CD  1 
ATOM   2835 C CD  B LYS A 1 283 ? 5.16501   6.01140   -28.61010 0.092 13.93482 ? 364  LYS A CD  1 
ATOM   2836 C CE  A LYS A 1 283 ? 4.48299   6.37718   -28.45177 0.908 22.61985 ? 364  LYS A CE  1 
ATOM   2837 C CE  B LYS A 1 283 ? 3.75966   6.32353   -28.13030 0.092 14.94596 ? 364  LYS A CE  1 
ATOM   2838 N NZ  A LYS A 1 283 ? 3.75327   7.62378   -28.81433 0.908 19.05657 ? 364  LYS A NZ  1 
ATOM   2839 N NZ  B LYS A 1 283 ? 3.40951   7.74383   -28.40385 0.092 17.34606 ? 364  LYS A NZ  1 
ATOM   2840 N N   A GLY A 1 284 ? 4.59209   0.33089   -28.81119 0.908 9.79203  ? 365  GLY A N   1 
ATOM   2841 N N   B GLY A 1 284 ? 4.42447   0.65659   -28.32560 0.092 7.81490  ? 365  GLY A N   1 
ATOM   2842 C CA  A GLY A 1 284 ? 4.49402   -0.56979  -29.93771 0.908 10.60516 ? 365  GLY A CA  1 
ATOM   2843 C CA  B GLY A 1 284 ? 4.40578   -0.21336  -29.48581 0.092 10.19961 ? 365  GLY A CA  1 
ATOM   2844 C C   A GLY A 1 284 ? 5.28374   -1.84647  -29.78542 0.908 8.84911  ? 365  GLY A C   1 
ATOM   2845 C C   B GLY A 1 284 ? 5.47707   -1.28593  -29.52359 0.092 10.42172 ? 365  GLY A C   1 
ATOM   2846 O O   A GLY A 1 284 ? 5.32716   -2.65086  -30.72376 0.908 10.43285 ? 365  GLY A O   1 
ATOM   2847 O O   B GLY A 1 284 ? 6.19301   -1.41348  -30.51979 0.092 11.44516 ? 365  GLY A O   1 
ATOM   2848 N N   A ALA A 1 285 ? 5.92095   -2.05472  -28.63810 0.908 8.43469  ? 366  ALA A N   1 
ATOM   2849 N N   B ALA A 1 285 ? 5.60058   -2.06180  -28.45273 0.092 8.96033  ? 366  ALA A N   1 
ATOM   2850 C CA  A ALA A 1 285 ? 6.61784   -3.30497  -28.40998 0.908 8.66249  ? 366  ALA A CA  1 
ATOM   2851 C CA  B ALA A 1 285 ? 6.45854   -3.23535  -28.41794 0.092 8.73064  ? 366  ALA A CA  1 
ATOM   2852 C C   A ALA A 1 285 ? 5.63662   -4.47227  -28.42640 0.908 8.30570  ? 366  ALA A C   1 
ATOM   2853 C C   B ALA A 1 285 ? 5.58523   -4.48204  -28.44233 0.092 8.38746  ? 366  ALA A C   1 
ATOM   2854 O O   A ALA A 1 285 ? 4.46382   -4.34574  -28.05643 0.908 9.51089  ? 366  ALA A O   1 
ATOM   2855 O O   B ALA A 1 285 ? 4.40428   -4.43216  -28.08964 0.092 9.38523  ? 366  ALA A O   1 
ATOM   2856 C CB  A ALA A 1 285 ? 7.35691   -3.26342  -27.07588 0.908 8.68371  ? 366  ALA A CB  1 
ATOM   2857 C CB  B ALA A 1 285 ? 7.31507   -3.23704  -27.14785 0.092 8.63421  ? 366  ALA A CB  1 
ATOM   2858 N N   . GLY A 1 286 ? 6.15201   -5.61107  -28.85736 1.000 8.35456  ? 367  GLY A N   1 
ATOM   2859 C CA  . GLY A 1 286 ? 5.39807   -6.84709  -28.88375 1.000 8.01437  ? 367  GLY A CA  1 
ATOM   2860 C C   . GLY A 1 286 ? 6.15626   -7.97319  -28.21680 1.000 8.03506  ? 367  GLY A C   1 
ATOM   2861 O O   . GLY A 1 286 ? 7.38450   -7.96997  -28.15362 1.000 8.41346  ? 367  GLY A O   1 
ATOM   2862 N N   . PHE A 1 287 ? 5.40232   -8.94358  -27.70562 1.000 8.34749  ? 368  PHE A N   1 
ATOM   2863 C CA  . PHE A 1 287 ? 6.03793   -10.15209 -27.20591 1.000 8.51396  ? 368  PHE A CA  1 
ATOM   2864 C C   . PHE A 1 287 ? 6.86630   -10.78162 -28.32343 1.000 7.92185  ? 368  PHE A C   1 
ATOM   2865 O O   . PHE A 1 287 ? 6.45455   -10.79416 -29.48718 1.000 8.47855  ? 368  PHE A O   1 
ATOM   2866 C CB  . PHE A 1 287 ? 4.97769   -11.14833 -26.72981 1.000 8.87061  ? 368  PHE A CB  1 
ATOM   2867 C CG  . PHE A 1 287 ? 4.33575   -10.79733 -25.40743 1.000 7.92452  ? 368  PHE A CG  1 
ATOM   2868 C CD1 . PHE A 1 287 ? 5.08338   -10.73154 -24.24424 1.000 7.82432  ? 368  PHE A CD1 1 
ATOM   2869 C CD2 . PHE A 1 287 ? 2.96654   -10.57847 -25.32069 1.000 8.89044  ? 368  PHE A CD2 1 
ATOM   2870 C CE1 . PHE A 1 287 ? 4.48919   -10.43403 -23.02766 1.000 9.09956  ? 368  PHE A CE1 1 
ATOM   2871 C CE2 . PHE A 1 287 ? 2.37200   -10.27746 -24.11029 1.000 8.90030  ? 368  PHE A CE2 1 
ATOM   2872 C CZ  . PHE A 1 287 ? 3.12671   -10.20666 -22.96219 1.000 8.50499  ? 368  PHE A CZ  1 
ATOM   2873 N N   . GLY A 1 288 ? 8.04043   -11.31024 -27.96762 1.000 8.79553  ? 369  GLY A N   1 
ATOM   2874 C CA  . GLY A 1 288 ? 8.97185   -11.84920 -28.93093 1.000 8.03880  ? 369  GLY A CA  1 
ATOM   2875 C C   . GLY A 1 288 ? 9.05973   -13.36168 -28.90909 1.000 8.67581  ? 369  GLY A C   1 
ATOM   2876 O O   . GLY A 1 288 ? 8.12962   -14.06518 -28.49090 1.000 8.97792  ? 369  GLY A O   1 
ATOM   2877 N N   . THR A 1 289 ? 10.18911  -13.86980 -29.40280 1.000 9.04778  ? 370  THR A N   1 
ATOM   2878 C CA  . THR A 1 289 ? 10.41967  -15.30311 -29.51007 1.000 8.05203  ? 370  THR A CA  1 
ATOM   2879 C C   . THR A 1 289 ? 10.13370  -15.99265 -28.18933 1.000 8.30908  ? 370  THR A C   1 
ATOM   2880 O O   . THR A 1 289 ? 10.58483  -15.54600 -27.12944 1.000 8.55087  ? 370  THR A O   1 
ATOM   2881 C CB  . THR A 1 289 ? 11.87638  -15.53140 -29.90965 1.000 9.31918  ? 370  THR A CB  1 
ATOM   2882 O OG1 . THR A 1 289 ? 12.14415  -14.84080 -31.13653 1.000 10.82146 ? 370  THR A OG1 1 
ATOM   2883 C CG2 . THR A 1 289 ? 12.17549  -17.01003 -30.05251 1.000 10.26682 ? 370  THR A CG2 1 
ATOM   2884 N N   . ARG A 1 290 ? 9.36848   -17.08118 -28.25124 1.000 9.24356  ? 371  ARG A N   1 
ATOM   2885 C CA  A ARG A 1 290 ? 9.01221   -17.78996 -27.03853 0.458 8.98336  ? 371  ARG A CA  1 
ATOM   2886 C CA  B ARG A 1 290 ? 9.01270   -17.79507 -27.03775 0.542 8.98962  ? 371  ARG A CA  1 
ATOM   2887 C C   . ARG A 1 290 ? 10.24540  -18.46418 -26.44029 1.000 8.02743  ? 371  ARG A C   1 
ATOM   2888 O O   . ARG A 1 290 ? 11.16081  -18.86004 -27.16855 1.000 8.58469  ? 371  ARG A O   1 
ATOM   2889 C CB  A ARG A 1 290 ? 7.94907   -18.84588 -27.33262 0.458 10.94081 ? 371  ARG A CB  1 
ATOM   2890 C CB  B ARG A 1 290 ? 7.97212   -18.87488 -27.32365 0.542 10.88663 ? 371  ARG A CB  1 
ATOM   2891 C CG  A ARG A 1 290 ? 6.81864   -18.36853 -28.22995 0.458 11.16450 ? 371  ARG A CG  1 
ATOM   2892 C CG  B ARG A 1 290 ? 6.77363   -18.39953 -28.09379 0.542 10.39626 ? 371  ARG A CG  1 
ATOM   2893 C CD  A ARG A 1 290 ? 5.91321   -17.39671 -27.49984 0.458 11.96156 ? 371  ARG A CD  1 
ATOM   2894 C CD  B ARG A 1 290 ? 6.10714   -17.22267 -27.41695 0.542 10.97184 ? 371  ARG A CD  1 
ATOM   2895 N NE  A ARG A 1 290 ? 6.02277   -16.03567 -28.01536 0.458 13.78429 ? 371  ARG A NE  1 
ATOM   2896 N NE  B ARG A 1 290 ? 4.82014   -16.97024 -28.04795 0.542 11.35030 ? 371  ARG A NE  1 
ATOM   2897 C CZ  A ARG A 1 290 ? 5.32749   -15.55580 -29.04003 0.458 14.22931 ? 371  ARG A CZ  1 
ATOM   2898 C CZ  B ARG A 1 290 ? 4.59676   -16.04937 -28.97521 0.542 14.98512 ? 371  ARG A CZ  1 
ATOM   2899 N NH1 A ARG A 1 290 ? 4.47225   -16.31112 -29.71281 0.458 15.23663 ? 371  ARG A NH1 1 
ATOM   2900 N NH1 B ARG A 1 290 ? 5.53695   -15.19631 -29.34635 0.542 13.29079 ? 371  ARG A NH1 1 
ATOM   2901 N NH2 A ARG A 1 290 ? 5.48635   -14.28154 -29.39200 0.458 10.29526 ? 371  ARG A NH2 1 
ATOM   2902 N NH2 B ARG A 1 290 ? 3.40591   -15.99867 -29.56354 0.542 13.43464 ? 371  ARG A NH2 1 
ATOM   2903 N N   . PRO A 1 291 ? 10.28573  -18.61462 -25.11944 1.000 7.89491  ? 372  PRO A N   1 
ATOM   2904 C CA  . PRO A 1 291 ? 11.42958  -19.28280 -24.49381 1.000 7.92197  ? 372  PRO A CA  1 
ATOM   2905 C C   . PRO A 1 291 ? 11.70869  -20.64267 -25.12034 1.000 7.51100  ? 372  PRO A C   1 
ATOM   2906 O O   . PRO A 1 291 ? 10.78568  -21.40867 -25.42130 1.000 9.05322  ? 372  PRO A O   1 
ATOM   2907 C CB  . PRO A 1 291 ? 11.00132  -19.40466 -23.03093 1.000 8.81516  ? 372  PRO A CB  1 
ATOM   2908 C CG  . PRO A 1 291 ? 10.10596  -18.21238 -22.82962 1.000 8.47320  ? 372  PRO A CG  1 
ATOM   2909 C CD  . PRO A 1 291 ? 9.33386   -18.09893 -24.11866 1.000 7.82102  ? 372  PRO A CD  1 
ATOM   2910 N N   . THR A 1 292 ? 12.99235  -20.92785 -25.34337 1.000 8.19890  ? 373  THR A N   1 
ATOM   2911 C CA  . THR A 1 292 ? 13.38955  -22.18610 -25.95922 1.000 9.17159  ? 373  THR A CA  1 
ATOM   2912 C C   . THR A 1 292 ? 14.88600  -22.39075 -25.75885 1.000 8.08295  ? 373  THR A C   1 
ATOM   2913 O O   . THR A 1 292 ? 15.66526  -21.42516 -25.74920 1.000 8.01369  ? 373  THR A O   1 
ATOM   2914 C CB  . THR A 1 292 ? 13.07553  -22.20017 -27.46384 1.000 9.21699  ? 373  THR A CB  1 
ATOM   2915 O OG1 . THR A 1 292 ? 13.59308  -23.40162 -28.03961 1.000 9.69121  ? 373  THR A OG1 1 
ATOM   2916 C CG2 . THR A 1 292 ? 13.73011  -21.01737 -28.18806 1.000 10.85608 ? 373  THR A CG2 1 
ATOM   2917 N N   . THR A 1 293 ? 15.27824  -23.65528 -25.62584 1.000 9.36186  ? 374  THR A N   1 
ATOM   2918 C CA  . THR A 1 293 ? 16.68673  -24.01266 -25.61991 1.000 8.71559  ? 374  THR A CA  1 
ATOM   2919 C C   . THR A 1 293 ? 17.24099  -24.21011 -27.02424 1.000 10.70283 ? 374  THR A C   1 
ATOM   2920 O O   . THR A 1 293 ? 18.42640  -24.52152 -27.16336 1.000 10.75564 ? 374  THR A O   1 
ATOM   2921 C CB  . THR A 1 293 ? 16.94368  -25.26220 -24.76572 1.000 11.44775 ? 374  THR A CB  1 
ATOM   2922 O OG1 . THR A 1 293 ? 16.20279  -26.37333 -25.28977 1.000 14.72765 ? 374  THR A OG1 1 
ATOM   2923 C CG2 . THR A 1 293 ? 16.52413  -25.01081 -23.32023 1.000 12.08653 ? 374  THR A CG2 1 
ATOM   2924 N N   . ASN A 1 294 ? 16.42157  -24.03245 -28.06274 1.000 9.92811  ? 375  ASN A N   1 
ATOM   2925 C CA  . ASN A 1 294 ? 16.88027  -24.07130 -29.45369 1.000 12.03559 ? 375  ASN A CA  1 
ATOM   2926 C C   . ASN A 1 294 ? 17.27620  -22.64532 -29.81994 1.000 11.17686 ? 375  ASN A C   1 
ATOM   2927 O O   . ASN A 1 294 ? 16.48453  -21.87501 -30.36277 1.000 13.82945 ? 375  ASN A O   1 
ATOM   2928 C CB  . ASN A 1 294 ? 15.76844  -24.58831 -30.35788 1.000 15.20505 ? 375  ASN A CB  1 
ATOM   2929 C CG  . ASN A 1 294 ? 16.12620  -24.51339 -31.82788 1.000 20.34035 ? 375  ASN A CG  1 
ATOM   2930 O OD1 . ASN A 1 294 ? 17.30085  -24.48000 -32.19479 1.000 21.43594 ? 375  ASN A OD1 1 
ATOM   2931 N ND2 . ASN A 1 294 ? 15.10812  -24.46132 -32.68003 1.000 30.25741 ? 375  ASN A ND2 1 
ATOM   2932 N N   . THR A 1 295 ? 18.51985  -22.28386 -29.51624 1.000 11.43816 ? 376  THR A N   1 
ATOM   2933 C CA  . THR A 1 295 ? 18.92174  -20.88644 -29.47259 1.000 11.35515 ? 376  THR A CA  1 
ATOM   2934 C C   . THR A 1 295 ? 19.72315  -20.42983 -30.67817 1.000 12.98774 ? 376  THR A C   1 
ATOM   2935 O O   . THR A 1 295 ? 19.90179  -19.22029 -30.84959 1.000 15.27737 ? 376  THR A O   1 
ATOM   2936 C CB  . THR A 1 295 ? 19.78499  -20.63861 -28.24149 1.000 9.61198  ? 376  THR A CB  1 
ATOM   2937 O OG1 . THR A 1 295 ? 20.98923  -21.40654 -28.37385 1.000 9.50144  ? 376  THR A OG1 1 
ATOM   2938 C CG2 . THR A 1 295 ? 19.04315  -21.03586 -26.98638 1.000 9.79032  ? 376  THR A CG2 1 
ATOM   2939 N N   . GLY A 1 296 ? 20.24765  -21.35107 -31.47998 1.000 12.82661 ? 377  GLY A N   1 
ATOM   2940 C CA  . GLY A 1 296 ? 21.07685  -20.97603 -32.60326 1.000 16.71149 ? 377  GLY A CA  1 
ATOM   2941 C C   . GLY A 1 296 ? 22.49394  -20.57232 -32.26389 1.000 14.31160 ? 377  GLY A C   1 
ATOM   2942 O O   . GLY A 1 296 ? 23.17055  -19.99419 -33.12573 1.000 15.95577 ? 377  GLY A O   1 
ATOM   2943 N N   . SER A 1 297 ? 22.97855  -20.86608 -31.05369 1.000 11.87388 ? 378  SER A N   1 
ATOM   2944 C CA  . SER A 1 297 ? 24.32253  -20.44708 -30.67834 1.000 12.28616 ? 378  SER A CA  1 
ATOM   2945 C C   . SER A 1 297 ? 24.92509  -21.37085 -29.63384 1.000 10.47227 ? 378  SER A C   1 
ATOM   2946 O O   . SER A 1 297 ? 24.27939  -21.68505 -28.63048 1.000 10.35476 ? 378  SER A O   1 
ATOM   2947 C CB  . SER A 1 297 ? 24.29046  -19.04424 -30.08283 1.000 13.92066 ? 378  SER A CB  1 
ATOM   2948 O OG  . SER A 1 297 ? 25.53097  -18.74234 -29.47232 1.000 13.03064 ? 378  SER A OG  1 
ATOM   2949 N N   . GLN A 1 298 ? 26.20303  -21.72335 -29.84453 1.000 10.44831 ? 379  GLN A N   1 
ATOM   2950 C CA  . GLN A 1 298 ? 26.94459  -22.52607 -28.87886 1.000 8.84793  ? 379  GLN A CA  1 
ATOM   2951 C C   . GLN A 1 298 ? 26.94147  -21.89381 -27.49600 1.000 9.13452  ? 379  GLN A C   1 
ATOM   2952 O O   . GLN A 1 298 ? 27.06813  -22.60032 -26.49196 1.000 11.46443 ? 379  GLN A O   1 
ATOM   2953 C CB  . GLN A 1 298 ? 28.39352  -22.70010 -29.34270 1.000 10.03433 ? 379  GLN A CB  1 
ATOM   2954 C CG  . GLN A 1 298 ? 29.14930  -21.39414 -29.58308 1.000 12.03334 ? 379  GLN A CG  1 
ATOM   2955 C CD  . GLN A 1 298 ? 30.58334  -21.63613 -30.00137 1.000 13.96853 ? 379  GLN A CD  1 
ATOM   2956 O OE1 . GLN A 1 298 ? 31.27445  -22.48813 -29.43917 1.000 17.41615 ? 379  GLN A OE1 1 
ATOM   2957 N NE2 . GLN A 1 298 ? 31.02309  -20.91958 -31.02646 1.000 15.22614 ? 379  GLN A NE2 1 
ATOM   2958 N N   . PHE A 1 299 ? 26.81965  -20.57046 -27.42095 1.000 8.20037  ? 380  PHE A N   1 
ATOM   2959 C CA  . PHE A 1 299 ? 26.98576  -19.86895 -26.15904 1.000 8.52673  ? 380  PHE A CA  1 
ATOM   2960 C C   . PHE A 1 299 ? 25.68767  -19.68827 -25.39134 1.000 8.48824  ? 380  PHE A C   1 
ATOM   2961 O O   . PHE A 1 299 ? 25.73437  -19.26767 -24.22865 1.000 9.41155  ? 380  PHE A O   1 
ATOM   2962 C CB  . PHE A 1 299 ? 27.59213  -18.48532 -26.40466 1.000 9.29474  ? 380  PHE A CB  1 
ATOM   2963 C CG  . PHE A 1 299 ? 28.92006  -18.52558 -27.10603 1.000 10.98909 ? 380  PHE A CG  1 
ATOM   2964 C CD1 . PHE A 1 299 ? 29.98698  -19.20453 -26.54424 1.000 12.49831 ? 380  PHE A CD1 1 
ATOM   2965 C CD2 . PHE A 1 299 ? 29.09679  -17.89300 -28.32809 1.000 11.30836 ? 380  PHE A CD2 1 
ATOM   2966 C CE1 . PHE A 1 299 ? 31.21399  -19.24326 -27.19079 1.000 12.20356 ? 380  PHE A CE1 1 
ATOM   2967 C CE2 . PHE A 1 299 ? 30.31757  -17.93430 -28.97616 1.000 12.77165 ? 380  PHE A CE2 1 
ATOM   2968 C CZ  . PHE A 1 299 ? 31.37048  -18.60645 -28.40648 1.000 14.49753 ? 380  PHE A CZ  1 
ATOM   2969 N N   . ILE A 1 300 ? 24.53927  -19.96870 -25.99955 1.000 7.94090  ? 381  ILE A N   1 
ATOM   2970 C CA  . ILE A 1 300 ? 23.25072  -19.57836 -25.43108 1.000 7.84539  ? 381  ILE A CA  1 
ATOM   2971 C C   . ILE A 1 300 ? 22.48432  -20.82160 -24.99623 1.000 7.46048  ? 381  ILE A C   1 
ATOM   2972 O O   . ILE A 1 300 ? 22.08238  -21.64590 -25.83131 1.000 8.18314  ? 381  ILE A O   1 
ATOM   2973 C CB  . ILE A 1 300 ? 22.43387  -18.70766 -26.39564 1.000 8.27739  ? 381  ILE A CB  1 
ATOM   2974 C CG1 . ILE A 1 300 ? 23.26093  -17.50417 -26.85655 1.000 8.87901  ? 381  ILE A CG1 1 
ATOM   2975 C CG2 . ILE A 1 300 ? 21.15328  -18.24642 -25.71944 1.000 9.49915  ? 381  ILE A CG2 1 
ATOM   2976 C CD1 . ILE A 1 300 ? 22.53130  -16.60209 -27.83079 1.000 10.46248 ? 381  ILE A CD1 1 
ATOM   2977 N N   . ASP A 1 301 ? 22.25817  -20.93127 -23.68320 1.000 7.13728  ? 382  ASP A N   1 
ATOM   2978 C CA  . ASP A 1 301 ? 21.50080  -22.04970 -23.12387 1.000 7.63677  ? 382  ASP A CA  1 
ATOM   2979 C C   . ASP A 1 301 ? 20.00793  -21.90817 -23.40399 1.000 6.88163  ? 382  ASP A C   1 
ATOM   2980 O O   . ASP A 1 301 ? 19.31269  -22.90852 -23.61185 1.000 7.91406  ? 382  ASP A O   1 
ATOM   2981 C CB  . ASP A 1 301 ? 21.70822  -22.12836 -21.60900 1.000 7.81420  ? 382  ASP A CB  1 
ATOM   2982 C CG  . ASP A 1 301 ? 23.08429  -22.62948 -21.21320 1.000 7.51653  ? 382  ASP A CG  1 
ATOM   2983 O OD1 . ASP A 1 301 ? 23.73556  -23.32212 -22.03101 1.000 9.65254  ? 382  ASP A OD1 1 
ATOM   2984 O OD2 . ASP A 1 301 ? 23.49595  -22.33235 -20.07101 1.000 8.88501  ? 382  ASP A OD2 1 
ATOM   2985 N N   . SER A 1 302 ? 19.48367  -20.68470 -23.36881 1.000 7.12554  ? 383  SER A N   1 
ATOM   2986 C CA  . SER A 1 302 ? 18.05356  -20.50947 -23.56545 1.000 7.00705  ? 383  SER A CA  1 
ATOM   2987 C C   . SER A 1 302 ? 17.73708  -19.07454 -23.95077 1.000 6.78161  ? 383  SER A C   1 
ATOM   2988 O O   . SER A 1 302 ? 18.33212  -18.11793 -23.42825 1.000 7.38747  ? 383  SER A O   1 
ATOM   2989 C CB  . SER A 1 302 ? 17.25460  -20.88902 -22.30775 1.000 7.59427  ? 383  SER A CB  1 
ATOM   2990 O OG  . SER A 1 302 ? 15.86426  -21.01607 -22.58207 1.000 7.76034  ? 383  SER A OG  1 
ATOM   2991 N N   . ILE A 1 303 ? 16.78256  -18.94673 -24.86790 1.000 7.11827  ? 384  ILE A N   1 
ATOM   2992 C CA  . ILE A 1 303 ? 15.97683  -17.74066 -24.97055 1.000 6.62600  ? 384  ILE A CA  1 
ATOM   2993 C C   . ILE A 1 303 ? 14.96088  -17.79453 -23.83996 1.000 6.88816  ? 384  ILE A C   1 
ATOM   2994 O O   . ILE A 1 303 ? 14.40176  -18.86115 -23.55435 1.000 7.37514  ? 384  ILE A O   1 
ATOM   2995 C CB  . ILE A 1 303 ? 15.29739  -17.67217 -26.35051 1.000 7.57155  ? 384  ILE A CB  1 
ATOM   2996 C CG1 . ILE A 1 303 ? 16.35581  -17.55549 -27.44896 1.000 8.84407  ? 384  ILE A CG1 1 
ATOM   2997 C CG2 . ILE A 1 303 ? 14.33446  -16.51026 -26.41655 1.000 8.60030  ? 384  ILE A CG2 1 
ATOM   2998 C CD1 . ILE A 1 303 ? 15.83601  -17.78332 -28.84754 1.000 10.54143 ? 384  ILE A CD1 1 
ATOM   2999 N N   . VAL A 1 304 ? 14.74961  -16.66746 -23.15652 1.000 6.75259  ? 385  VAL A N   1 
ATOM   3000 C CA  . VAL A 1 304 ? 13.92900  -16.61005 -21.95141 1.000 6.84484  ? 385  VAL A CA  1 
ATOM   3001 C C   . VAL A 1 304 ? 13.05607  -15.36146 -22.00515 1.000 6.73658  ? 385  VAL A C   1 
ATOM   3002 O O   . VAL A 1 304 ? 13.27774  -14.45779 -22.81439 1.000 6.67591  ? 385  VAL A O   1 
ATOM   3003 C CB  . VAL A 1 304 ? 14.78214  -16.61705 -20.66297 1.000 7.34636  ? 385  VAL A CB  1 
ATOM   3004 C CG1 . VAL A 1 304 ? 15.42898  -17.97043 -20.46503 1.000 8.42812  ? 385  VAL A CG1 1 
ATOM   3005 C CG2 . VAL A 1 304 ? 15.84473  -15.53121 -20.73191 1.000 7.35365  ? 385  VAL A CG2 1 
ATOM   3006 N N   . TRP A 1 305 ? 12.04384  -15.32593 -21.13206 1.000 6.74649  ? 386  TRP A N   1 
ATOM   3007 C CA  . TRP A 1 305 ? 11.26142  -14.11615 -20.86559 1.000 6.74914  ? 386  TRP A CA  1 
ATOM   3008 C C   . TRP A 1 305 ? 11.53850  -13.73694 -19.41818 1.000 6.19380  ? 386  TRP A C   1 
ATOM   3009 O O   . TRP A 1 305 ? 10.97080  -14.33251 -18.49310 1.000 6.87050  ? 386  TRP A O   1 
ATOM   3010 C CB  . TRP A 1 305 ? 9.76336   -14.33024 -21.09755 1.000 6.74203  ? 386  TRP A CB  1 
ATOM   3011 C CG  . TRP A 1 305 ? 9.34725   -14.37465 -22.53037 1.000 6.84606  ? 386  TRP A CG  1 
ATOM   3012 C CD1 . TRP A 1 305 ? 10.13945  -14.52674 -23.63663 1.000 7.61121  ? 386  TRP A CD1 1 
ATOM   3013 C CD2 . TRP A 1 305 ? 8.00645   -14.24868 -23.01984 1.000 7.73590  ? 386  TRP A CD2 1 
ATOM   3014 N NE1 . TRP A 1 305 ? 9.36969   -14.50863 -24.78344 1.000 8.02132  ? 386  TRP A NE1 1 
ATOM   3015 C CE2 . TRP A 1 305 ? 8.05582   -14.33851 -24.42713 1.000 7.63330  ? 386  TRP A CE2 1 
ATOM   3016 C CE3 . TRP A 1 305 ? 6.76364   -14.06433 -22.39919 1.000 8.37124  ? 386  TRP A CE3 1 
ATOM   3017 C CZ2 . TRP A 1 305 ? 6.90950   -14.25361 -25.22381 1.000 8.78752  ? 386  TRP A CZ2 1 
ATOM   3018 C CZ3 . TRP A 1 305 ? 5.62802   -13.97967 -23.19346 1.000 9.84668  ? 386  TRP A CZ3 1 
ATOM   3019 C CH2 . TRP A 1 305 ? 5.70952   -14.07761 -24.58722 1.000 9.40795  ? 386  TRP A CH2 1 
ATOM   3020 N N   . VAL A 1 306 ? 12.43007  -12.76347 -19.22002 1.000 6.60334  ? 387  VAL A N   1 
ATOM   3021 C CA  . VAL A 1 306 ? 12.84445  -12.37503 -17.87629 1.000 6.28130  ? 387  VAL A CA  1 
ATOM   3022 C C   . VAL A 1 306 ? 11.95664  -11.25383 -17.35421 1.000 6.36256  ? 387  VAL A C   1 
ATOM   3023 O O   . VAL A 1 306 ? 11.27888  -11.41987 -16.33403 1.000 6.62063  ? 387  VAL A O   1 
ATOM   3024 C CB  . VAL A 1 306 ? 14.33847  -12.00550 -17.77465 1.000 6.32534  ? 387  VAL A CB  1 
ATOM   3025 C CG1 . VAL A 1 306 ? 14.69638  -11.76376 -16.32704 1.000 7.45225  ? 387  VAL A CG1 1 
ATOM   3026 C CG2 . VAL A 1 306 ? 15.19910  -13.10276 -18.34589 1.000 7.99757  ? 387  VAL A CG2 1 
ATOM   3027 N N   . LYS A 1 307 ? 11.96580  -10.10387 -18.02710 1.000 6.80868  ? 388  LYS A N   1 
ATOM   3028 C CA  . LYS A 1 307 ? 11.04147  -9.03280  -17.66626 1.000 6.44506  ? 388  LYS A CA  1 
ATOM   3029 C C   . LYS A 1 307 ? 9.61466   -9.46683  -18.00334 1.000 7.08514  ? 388  LYS A C   1 
ATOM   3030 O O   . LYS A 1 307 ? 9.36088   -9.90240  -19.13392 1.000 7.96498  ? 388  LYS A O   1 
ATOM   3031 C CB  . LYS A 1 307 ? 11.39969  -7.77580  -18.45441 1.000 7.43390  ? 388  LYS A CB  1 
ATOM   3032 C CG  . LYS A 1 307 ? 10.38282  -6.63886  -18.38112 1.000 8.46546  ? 388  LYS A CG  1 
ATOM   3033 C CD  . LYS A 1 307 ? 10.34892  -5.97601  -17.00945 1.000 7.31635  ? 388  LYS A CD  1 
ATOM   3034 C CE  . LYS A 1 307 ? 9.28385   -4.90522  -16.95823 1.000 8.84129  ? 388  LYS A CE  1 
ATOM   3035 N NZ  . LYS A 1 307 ? 9.30453   -4.15567  -15.68087 1.000 9.04287  ? 388  LYS A NZ  1 
ATOM   3036 N N   . PRO A 1 308 ? 8.65863   -9.37552  -17.06745 1.000 6.76508  ? 389  PRO A N   1 
ATOM   3037 C CA  . PRO A 1 308 ? 7.28999   -9.80732  -17.38355 1.000 7.03692  ? 389  PRO A CA  1 
ATOM   3038 C C   . PRO A 1 308 ? 6.56509   -8.68617  -18.10967 1.000 7.28499  ? 389  PRO A C   1 
ATOM   3039 O O   . PRO A 1 308 ? 6.22247   -7.65911  -17.51758 1.000 7.93375  ? 389  PRO A O   1 
ATOM   3040 C CB  . PRO A 1 308 ? 6.68638   -10.09628 -15.99680 1.000 7.92876  ? 389  PRO A CB  1 
ATOM   3041 C CG  . PRO A 1 308 ? 7.87769   -10.07341 -15.02574 1.000 7.75473  ? 389  PRO A CG  1 
ATOM   3042 C CD  . PRO A 1 308 ? 8.78700   -9.06112  -15.64276 1.000 6.50208  ? 389  PRO A CD  1 
ATOM   3043 N N   . GLY A 1 309 ? 6.36708   -8.86413  -19.41198 1.000 7.78624  ? 390  GLY A N   1 
ATOM   3044 C CA  . GLY A 1 309 ? 5.78042   -7.81489  -20.22000 1.000 7.65234  ? 390  GLY A CA  1 
ATOM   3045 C C   . GLY A 1 309 ? 4.40801   -7.41674  -19.71644 1.000 7.71124  ? 390  GLY A C   1 
ATOM   3046 O O   . GLY A 1 309 ? 3.54440   -8.26611  -19.47389 1.000 7.92425  ? 390  GLY A O   1 
ATOM   3047 N N   . GLY A 1 310 ? 4.19405   -6.11553  -19.55632 1.000 7.73465  ? 391  GLY A N   1 
ATOM   3048 C CA  . GLY A 1 310 ? 3.00214   -5.57784  -18.94265 1.000 8.33348  ? 391  GLY A CA  1 
ATOM   3049 C C   . GLY A 1 310 ? 3.26087   -4.95219  -17.59285 1.000 7.29757  ? 391  GLY A C   1 
ATOM   3050 O O   . GLY A 1 310 ? 2.49364   -4.07849  -17.17086 1.000 8.13421  ? 391  GLY A O   1 
ATOM   3051 N N   . GLU A 1 311 ? 4.32430   -5.36148  -16.90333 1.000 7.14925  ? 392  GLU A N   1 
ATOM   3052 C CA  . GLU A 1 311 ? 4.75245   -4.65654  -15.70682 1.000 7.44014  ? 392  GLU A CA  1 
ATOM   3053 C C   . GLU A 1 311 ? 5.59278   -3.45689  -16.13410 1.000 7.08811  ? 392  GLU A C   1 
ATOM   3054 O O   . GLU A 1 311 ? 6.54482   -3.59452  -16.90885 1.000 7.63777  ? 392  GLU A O   1 
ATOM   3055 C CB  . GLU A 1 311 ? 5.52818   -5.59943  -14.78453 1.000 7.25152  ? 392  GLU A CB  1 
ATOM   3056 C CG  . GLU A 1 311 ? 4.66011   -6.72818  -14.24222 1.000 7.50469  ? 392  GLU A CG  1 
ATOM   3057 C CD  . GLU A 1 311 ? 5.41996   -7.76625  -13.44588 1.000 7.17660  ? 392  GLU A CD  1 
ATOM   3058 O OE1 . GLU A 1 311 ? 6.59778   -7.53526  -13.10024 1.000 8.32667  ? 392  GLU A OE1 1 
ATOM   3059 O OE2 . GLU A 1 311 ? 4.82185   -8.81958  -13.12589 1.000 7.79403  ? 392  GLU A OE2 1 
ATOM   3060 N N   . SER A 1 312 ? 5.23273   -2.27465  -15.64444 1.000 6.79617  ? 393  SER A N   1 
ATOM   3061 C CA  . SER A 1 312 ? 5.84916   -1.03754  -16.11113 1.000 7.10924  ? 393  SER A CA  1 
ATOM   3062 C C   . SER A 1 312 ? 7.36077   -1.01968  -15.86739 1.000 6.87868  ? 393  SER A C   1 
ATOM   3063 O O   . SER A 1 312 ? 7.87129   -1.61062  -14.90860 1.000 7.63871  ? 393  SER A O   1 
ATOM   3064 C CB  . SER A 1 312 ? 5.21302   0.14623   -15.38834 1.000 7.31124  ? 393  SER A CB  1 
ATOM   3065 O OG  . SER A 1 312 ? 5.78697   1.36446   -15.82517 1.000 7.83521  ? 393  SER A OG  1 
ATOM   3066 N N   . ASP A 1 313 ? 8.07301   -0.29113  -16.73537 1.000 7.59098  ? 394  ASP A N   1 
ATOM   3067 C CA  . ASP A 1 313 ? 9.49403   -0.01088  -16.55631 1.000 7.99069  ? 394  ASP A CA  1 
ATOM   3068 C C   . ASP A 1 313 ? 9.73772   1.21459   -15.69208 1.000 7.25070  ? 394  ASP A C   1 
ATOM   3069 O O   . ASP A 1 313 ? 10.88364  1.46574   -15.29716 1.000 8.78701  ? 394  ASP A O   1 
ATOM   3070 C CB  . ASP A 1 313 ? 10.16488  0.26291   -17.90727 1.000 8.92523  ? 394  ASP A CB  1 
ATOM   3071 C CG  . ASP A 1 313 ? 10.18601  -0.93245  -18.81390 1.000 8.47182  ? 394  ASP A CG  1 
ATOM   3072 O OD1 . ASP A 1 313 ? 10.38344  -2.06384  -18.30788 1.000 9.88650  ? 394  ASP A OD1 1 
ATOM   3073 O OD2 . ASP A 1 313 ? 10.03433  -0.73010  -20.03561 1.000 8.62804  ? 394  ASP A OD2 1 
ATOM   3074 N N   . GLY A 1 314 ? 8.70619   1.99811   -15.41673 1.000 8.28774  ? 395  GLY A N   1 
ATOM   3075 C CA  . GLY A 1 314 ? 8.89041   3.23847   -14.70479 1.000 8.91909  ? 395  GLY A CA  1 
ATOM   3076 C C   . GLY A 1 314 ? 7.74400   4.19540   -14.91608 1.000 8.49438  ? 395  GLY A C   1 
ATOM   3077 O O   . GLY A 1 314 ? 7.06792   4.16730   -15.95206 1.000 9.00026  ? 395  GLY A O   1 
ATOM   3078 N N   . THR A 1 315 ? 7.52816   5.05297   -13.93013 1.000 8.38982  ? 396  THR A N   1 
ATOM   3079 C CA  . THR A 1 315 ? 6.45081   6.01977   -13.99770 1.000 9.79395  ? 396  THR A CA  1 
ATOM   3080 C C   . THR A 1 315 ? 6.81138   7.18103   -14.91290 1.000 9.08553  ? 396  THR A C   1 
ATOM   3081 O O   . THR A 1 315 ? 7.96823   7.59031   -15.01011 1.000 9.76051  ? 396  THR A O   1 
ATOM   3082 C CB  . THR A 1 315 ? 6.13782   6.56359   -12.60410 1.000 9.40511  ? 396  THR A CB  1 
ATOM   3083 O OG1 . THR A 1 315 ? 5.06536   7.50486   -12.70735 1.000 10.96368 ? 396  THR A OG1 1 
ATOM   3084 C CG2 . THR A 1 315 ? 7.35210   7.26556   -11.98382 1.000 11.06177 ? 396  THR A CG2 1 
ATOM   3085 N N   A SER A 1 316 ? 5.80941   7.70580   -15.60863 0.618 9.58255  ? 397  SER A N   1 
ATOM   3086 N N   B SER A 1 316 ? 5.79228   7.72187   -15.57557 0.382 9.68749  ? 397  SER A N   1 
ATOM   3087 C CA  A SER A 1 316 ? 5.98426   8.93117   -16.37339 0.618 10.26338 ? 397  SER A CA  1 
ATOM   3088 C CA  B SER A 1 316 ? 5.92817   8.96785   -16.31396 0.382 10.40952 ? 397  SER A CA  1 
ATOM   3089 C C   A SER A 1 316 ? 5.55041   10.16267  -15.58942 0.618 11.35024 ? 397  SER A C   1 
ATOM   3090 C C   B SER A 1 316 ? 5.58522   10.19048  -15.47312 0.382 11.51209 ? 397  SER A C   1 
ATOM   3091 O O   A SER A 1 316 ? 5.47379   11.25544  -16.15877 0.618 12.44476 ? 397  SER A O   1 
ATOM   3092 O O   B SER A 1 316 ? 5.80922   11.31766  -15.93013 0.382 12.98428 ? 397  SER A O   1 
ATOM   3093 C CB  A SER A 1 316 ? 5.22468   8.84695   -17.69515 0.618 9.80329  ? 397  SER A CB  1 
ATOM   3094 C CB  B SER A 1 316 ? 5.04201   8.94212   -17.56236 0.382 10.54032 ? 397  SER A CB  1 
ATOM   3095 O OG  A SER A 1 316 ? 3.83202   8.72902   -17.46065 0.618 9.25741  ? 397  SER A OG  1 
ATOM   3096 O OG  B SER A 1 316 ? 3.66915   8.99175   -17.20937 0.382 12.53130 ? 397  SER A OG  1 
ATOM   3097 N N   A ASN A 1 317 ? 5.26506   10.00919  -14.29775 0.618 10.80121 ? 398  ASN A N   1 
ATOM   3098 N N   B ASN A 1 317 ? 5.04624   9.99581   -14.26591 0.382 10.12568 ? 398  ASN A N   1 
ATOM   3099 C CA  A ASN A 1 317 ? 4.76557   11.09321  -13.45660 0.618 12.39045 ? 398  ASN A CA  1 
ATOM   3100 C CA  B ASN A 1 317 ? 4.69182   11.09665  -13.37423 0.382 12.65520 ? 398  ASN A CA  1 
ATOM   3101 C C   A ASN A 1 317 ? 5.94763   11.80993  -12.81387 0.618 12.21972 ? 398  ASN A C   1 
ATOM   3102 C C   B ASN A 1 317 ? 5.92821   11.87868  -12.95445 0.382 12.26319 ? 398  ASN A C   1 
ATOM   3103 O O   A ASN A 1 317 ? 6.60931   11.25643  -11.92978 0.618 10.92402 ? 398  ASN A O   1 
ATOM   3104 O O   B ASN A 1 317 ? 6.76117   11.37229  -12.19504 0.382 11.97022 ? 398  ASN A O   1 
ATOM   3105 C CB  A ASN A 1 317 ? 3.84771   10.51132  -12.38529 0.618 13.59218 ? 398  ASN A CB  1 
ATOM   3106 C CB  B ASN A 1 317 ? 3.98406   10.56149  -12.12732 0.382 14.42758 ? 398  ASN A CB  1 
ATOM   3107 C CG  A ASN A 1 317 ? 3.47496   11.51745  -11.31274 0.618 17.58506 ? 398  ASN A CG  1 
ATOM   3108 C CG  B ASN A 1 317 ? 3.13500   11.61457  -11.43519 0.382 17.34959 ? 398  ASN A CG  1 
ATOM   3109 O OD1 A ASN A 1 317 ? 3.65460   12.72337  -11.47736 0.618 13.19187 ? 398  ASN A OD1 1 
ATOM   3110 O OD1 B ASN A 1 317 ? 3.65540   12.51419  -10.77644 0.382 18.51394 ? 398  ASN A OD1 1 
ATOM   3111 N ND2 A ASN A 1 317 ? 2.95870   11.01731  -10.19527 0.618 20.00383 ? 398  ASN A ND2 1 
ATOM   3112 N ND2 B ASN A 1 317 ? 1.82031   11.48632  -11.55458 0.382 14.82446 ? 398  ASN A ND2 1 
ATOM   3113 N N   A SER A 1 318 ? 6.18465   13.06061  -13.22221 0.618 14.44162 ? 399  SER A N   1 
ATOM   3114 N N   B SER A 1 318 ? 6.04669   13.12202  -13.42300 0.382 14.48647 ? 399  SER A N   1 
ATOM   3115 C CA  A SER A 1 318 ? 7.31989   13.81738  -12.70230 0.618 14.09917 ? 399  SER A CA  1 
ATOM   3116 C CA  B SER A 1 318 ? 7.24255   13.91308  -13.15628 0.382 14.09811 ? 399  SER A CA  1 
ATOM   3117 C C   A SER A 1 318 ? 7.14290   14.25195  -11.25211 0.618 14.83073 ? 399  SER A C   1 
ATOM   3118 C C   B SER A 1 318 ? 7.38674   14.32442  -11.69547 0.382 13.68443 ? 399  SER A C   1 
ATOM   3119 O O   A SER A 1 318 ? 8.09575   14.77419  -10.66171 0.618 16.68908 ? 399  SER A O   1 
ATOM   3120 O O   B SER A 1 318 ? 8.42624   14.88535  -11.33163 0.382 15.64658 ? 399  SER A O   1 
ATOM   3121 C CB  A SER A 1 318 ? 7.64953   15.01074  -13.60524 0.618 17.61341 ? 399  SER A CB  1 
ATOM   3122 C CB  B SER A 1 318 ? 7.29796   15.13566  -14.07604 0.382 16.86842 ? 399  SER A CB  1 
ATOM   3123 O OG  A SER A 1 318 ? 6.62963   15.98965  -13.55710 0.618 16.55507 ? 399  SER A OG  1 
ATOM   3124 O OG  B SER A 1 318 ? 6.24515   16.03537  -13.79171 0.382 19.17971 ? 399  SER A OG  1 
ATOM   3125 N N   A SER A 1 319 ? 5.96330   14.05378  -10.66589 0.618 17.34169 ? 400  SER A N   1 
ATOM   3126 N N   B SER A 1 319 ? 6.38776   14.05428  -10.85456 0.382 13.07413 ? 400  SER A N   1 
ATOM   3127 C CA  A SER A 1 319 ? 5.80077   14.26002  -9.23458  0.618 14.15671 ? 400  SER A CA  1 
ATOM   3128 C CA  B SER A 1 319 ? 6.43892   14.39168  -9.43735  0.382 15.23283 ? 400  SER A CA  1 
ATOM   3129 C C   A SER A 1 319 ? 6.32619   13.09003  -8.41422  0.618 15.08578 ? 400  SER A C   1 
ATOM   3130 C C   B SER A 1 319 ? 6.78284   13.20473  -8.54376  0.382 11.27980 ? 400  SER A C   1 
ATOM   3131 O O   A SER A 1 319 ? 6.38232   13.19327  -7.18440  0.618 15.91351 ? 400  SER A O   1 
ATOM   3132 O O   B SER A 1 319 ? 7.08809   13.40998  -7.36401  0.382 12.82467 ? 400  SER A O   1 
ATOM   3133 C CB  A SER A 1 319 ? 4.32866   14.50786  -8.89388  0.618 18.76157 ? 400  SER A CB  1 
ATOM   3134 C CB  B SER A 1 319 ? 5.10635   15.00317  -8.98403  0.382 15.77093 ? 400  SER A CB  1 
ATOM   3135 O OG  A SER A 1 319 ? 3.91027   15.78491  -9.34275  0.618 22.83353 ? 400  SER A OG  1 
ATOM   3136 O OG  B SER A 1 319 ? 4.83015   16.20788  -9.67884  0.382 18.77417 ? 400  SER A OG  1 
ATOM   3137 N N   . SER A 1 320 ? 6.72073   11.98120  -9.06363  1.000 14.16881 ? 401  SER A N   1 
ATOM   3138 C CA  . SER A 1 320 ? 7.14686   10.81773  -8.29872  1.000 12.18918 ? 401  SER A CA  1 
ATOM   3139 C C   . SER A 1 320 ? 8.61425   10.94618  -7.90519  1.000 11.66239 ? 401  SER A C   1 
ATOM   3140 O O   . SER A 1 320 ? 9.43553   11.40746  -8.70349  1.000 12.86644 ? 401  SER A O   1 
ATOM   3141 C CB  . SER A 1 320 ? 6.99580   9.54677   -9.13205  1.000 12.03365 ? 401  SER A CB  1 
ATOM   3142 O OG  . SER A 1 320 ? 7.65080   8.45962   -8.48719  1.000 10.90654 ? 401  SER A OG  1 
ATOM   3143 N N   . PRO A 1 321 ? 8.99025   10.49172  -6.70649  1.000 14.03188 ? 402  PRO A N   1 
ATOM   3144 C CA  . PRO A 1 321 ? 10.41996  10.41390  -6.37491  1.000 15.44651 ? 402  PRO A CA  1 
ATOM   3145 C C   . PRO A 1 321 ? 11.18301  9.44536   -7.26261  1.000 11.35915 ? 402  PRO A C   1 
ATOM   3146 O O   . PRO A 1 321 ? 12.41847  9.50518   -7.29570  1.000 14.83041 ? 402  PRO A O   1 
ATOM   3147 C CB  . PRO A 1 321 ? 10.42692  9.97404   -4.90478  1.000 16.02300 ? 402  PRO A CB  1 
ATOM   3148 C CG  . PRO A 1 321 ? 9.11580   9.31424   -4.69261  1.000 20.71822 ? 402  PRO A CG  1 
ATOM   3149 C CD  . PRO A 1 321 ? 8.13624   9.97150   -5.62434  1.000 13.93012 ? 402  PRO A CD  1 
ATOM   3150 N N   . ARG A 1 322 ? 10.48599  8.57297   -7.99823  1.000 10.45834 ? 403  ARG A N   1 
ATOM   3151 C CA  . ARG A 1 322 ? 11.11016  7.63859   -8.92571  1.000 9.26466  ? 403  ARG A CA  1 
ATOM   3152 C C   . ARG A 1 322 ? 10.96423  8.07107   -10.38187 1.000 9.94615  ? 403  ARG A C   1 
ATOM   3153 O O   . ARG A 1 322 ? 11.07063  7.24017   -11.29096 1.000 11.57695 ? 403  ARG A O   1 
ATOM   3154 C CB  . ARG A 1 322 ? 10.58184  6.22511   -8.68729  1.000 9.39978  ? 403  ARG A CB  1 
ATOM   3155 C CG  . ARG A 1 322 ? 10.79548  5.76667   -7.24776  1.000 9.84166  ? 403  ARG A CG  1 
ATOM   3156 C CD  . ARG A 1 322 ? 10.86384  4.26024   -7.11846  1.000 10.35749 ? 403  ARG A CD  1 
ATOM   3157 N NE  . ARG A 1 322 ? 9.68139   3.61332   -7.67473  1.000 10.08307 ? 403  ARG A NE  1 
ATOM   3158 C CZ  . ARG A 1 322 ? 9.58762   2.30736   -7.88445  1.000 9.51081  ? 403  ARG A CZ  1 
ATOM   3159 N NH1 . ARG A 1 322 ? 10.55607  1.48092   -7.52526  1.000 9.24696  ? 403  ARG A NH1 1 
ATOM   3160 N NH2 . ARG A 1 322 ? 8.50518   1.82052   -8.48712  1.000 10.00424 ? 403  ARG A NH2 1 
ATOM   3161 N N   A TYR A 1 323 ? 10.71558  9.35311   -10.63462 0.908 10.78899 ? 404  TYR A N   1 
ATOM   3162 N N   B TYR A 1 323 ? 10.76578  9.36773   -10.60742 0.092 11.14145 ? 404  TYR A N   1 
ATOM   3163 C CA  A TYR A 1 323 ? 10.58057  9.81234   -12.01114 0.908 11.40227 ? 404  TYR A CA  1 
ATOM   3164 C CA  B TYR A 1 323 ? 10.69053  9.92490   -11.94736 0.092 11.40901 ? 404  TYR A CA  1 
ATOM   3165 C C   A TYR A 1 323 ? 11.92910  9.83832   -12.71841 0.908 11.35810 ? 404  TYR A C   1 
ATOM   3166 C C   B TYR A 1 323 ? 12.07408  9.99176   -12.57432 0.092 12.12532 ? 404  TYR A C   1 
ATOM   3167 O O   A TYR A 1 323 ? 12.88329  10.45935  -12.23860 0.908 12.11481 ? 404  TYR A O   1 
ATOM   3168 O O   B TYR A 1 323 ? 13.02851  10.47501  -11.95651 0.092 12.62683 ? 404  TYR A O   1 
ATOM   3169 C CB  A TYR A 1 323 ? 9.97565   11.20897  -12.04816 0.908 11.48903 ? 404  TYR A CB  1 
ATOM   3170 C CB  B TYR A 1 323 ? 10.11611  11.33766  -11.89192 0.092 11.92928 ? 404  TYR A CB  1 
ATOM   3171 C CG  A TYR A 1 323 ? 9.91932   11.78537  -13.44256 0.908 12.21738 ? 404  TYR A CG  1 
ATOM   3172 C CG  B TYR A 1 323 ? 10.04875  12.00637  -13.24589 0.092 13.02617 ? 404  TYR A CG  1 
ATOM   3173 C CD1 A TYR A 1 323 ? 9.07811   11.23765  -14.40603 0.908 12.75705 ? 404  TYR A CD1 1 
ATOM   3174 C CD1 B TYR A 1 323 ? 9.45684   11.36616  -14.32664 0.092 12.57590 ? 404  TYR A CD1 1 
ATOM   3175 C CD2 A TYR A 1 323 ? 10.70554  12.87599  -13.79720 0.908 12.59502 ? 404  TYR A CD2 1 
ATOM   3176 C CD2 B TYR A 1 323 ? 10.59908  13.26678  -13.45086 0.092 14.19403 ? 404  TYR A CD2 1 
ATOM   3177 C CE1 A TYR A 1 323 ? 9.01971   11.76059  -15.68198 0.908 14.22486 ? 404  TYR A CE1 1 
ATOM   3178 C CE1 B TYR A 1 323 ? 9.39451   11.96831  -15.56772 0.092 13.29690 ? 404  TYR A CE1 1 
ATOM   3179 C CE2 A TYR A 1 323 ? 10.65135  13.40866  -15.07637 0.908 14.02582 ? 404  TYR A CE2 1 
ATOM   3180 C CE2 B TYR A 1 323 ? 10.54133  13.87766  -14.69161 0.092 14.89912 ? 404  TYR A CE2 1 
ATOM   3181 C CZ  A TYR A 1 323 ? 9.80665   12.84519  -16.01102 0.908 13.74926 ? 404  TYR A CZ  1 
ATOM   3182 C CZ  B TYR A 1 323 ? 9.93836   13.22224  -15.74559 0.092 14.03258 ? 404  TYR A CZ  1 
ATOM   3183 O OH  A TYR A 1 323 ? 9.73587   13.36140  -17.28624 0.908 15.40323 ? 404  TYR A OH  1 
ATOM   3184 O OH  B TYR A 1 323 ? 9.87771   13.81954  -16.98380 0.092 14.80087 ? 404  TYR A OH  1 
ATOM   3185 N N   A ASP A 1 324 ? 11.99142  9.18802   -13.87655 0.908 11.37918 ? 405  ASP A N   1 
ATOM   3186 N N   B ASP A 1 324 ? 12.17190  9.51508   -13.80773 0.092 12.15587 ? 405  ASP A N   1 
ATOM   3187 C CA  A ASP A 1 324 ? 13.14189  9.22930   -14.76570 0.908 10.15857 ? 405  ASP A CA  1 
ATOM   3188 C CA  B ASP A 1 324 ? 13.32351  9.74362   -14.66229 0.092 12.39395 ? 405  ASP A CA  1 
ATOM   3189 C C   A ASP A 1 324 ? 12.65714  9.74166   -16.11334 0.908 9.73774  ? 405  ASP A C   1 
ATOM   3190 C C   B ASP A 1 324 ? 12.80712  10.29149  -15.98351 0.092 11.91401 ? 405  ASP A C   1 
ATOM   3191 O O   A ASP A 1 324 ? 11.70948  9.19100   -16.68217 0.908 9.64770  ? 405  ASP A O   1 
ATOM   3192 O O   B ASP A 1 324 ? 11.79990  9.80866   -16.50912 0.092 12.46835 ? 405  ASP A O   1 
ATOM   3193 C CB  A ASP A 1 324 ? 13.71961  7.82553   -14.91788 0.908 10.34925 ? 405  ASP A CB  1 
ATOM   3194 C CB  B ASP A 1 324 ? 14.12020  8.44886   -14.86776 0.092 12.21050 ? 405  ASP A CB  1 
ATOM   3195 C CG  A ASP A 1 324 ? 15.06288  7.82397   -15.58954 0.908 11.37628 ? 405  ASP A CG  1 
ATOM   3196 C CG  B ASP A 1 324 ? 14.38712  8.15228   -16.32382 0.092 11.66443 ? 405  ASP A CG  1 
ATOM   3197 O OD1 A ASP A 1 324 ? 15.14905  8.26391   -16.75417 0.908 12.28511 ? 405  ASP A OD1 1 
ATOM   3198 O OD1 B ASP A 1 324 ? 13.52685  7.51032   -16.96257 0.092 11.78307 ? 405  ASP A OD1 1 
ATOM   3199 O OD2 A ASP A 1 324 ? 16.03041  7.38550   -14.93670 0.908 13.81565 ? 405  ASP A OD2 1 
ATOM   3200 O OD2 B ASP A 1 324 ? 15.45452  8.56119   -16.82645 0.092 12.95476 ? 405  ASP A OD2 1 
ATOM   3201 N N   A SER A 1 325 ? 13.30137  10.79344  -16.62428 0.908 10.16466 ? 406  SER A N   1 
ATOM   3202 N N   B SER A 1 325 ? 13.48261  11.31924  -16.50505 0.092 12.91696 ? 406  SER A N   1 
ATOM   3203 C CA  A SER A 1 325 ? 12.81661  11.41532  -17.85060 0.908 11.00120 ? 406  SER A CA  1 
ATOM   3204 C CA  B SER A 1 325 ? 12.96961  12.01214  -17.68430 0.092 13.21967 ? 406  SER A CA  1 
ATOM   3205 C C   A SER A 1 325 ? 12.87965  10.48413  -19.05768 0.908 9.27964  ? 406  SER A C   1 
ATOM   3206 C C   B SER A 1 325 ? 12.87683  11.09116  -18.89382 0.092 11.89054 ? 406  SER A C   1 
ATOM   3207 O O   A SER A 1 325 ? 12.23581  10.77863  -20.06979 0.908 9.47323  ? 406  SER A O   1 
ATOM   3208 O O   B SER A 1 325 ? 12.06612  11.33506  -19.79483 0.092 11.59451 ? 406  SER A O   1 
ATOM   3209 C CB  A SER A 1 325 ? 13.55730  12.72196  -18.12207 0.908 15.19425 ? 406  SER A CB  1 
ATOM   3210 C CB  B SER A 1 325 ? 13.82581  13.23792  -17.99785 0.092 15.43303 ? 406  SER A CB  1 
ATOM   3211 O OG  A SER A 1 325 ? 14.92606  12.46994  -18.35315 0.908 16.11075 ? 406  SER A OG  1 
ATOM   3212 O OG  B SER A 1 325 ? 15.16868  12.86739  -18.25281 0.092 17.02152 ? 406  SER A OG  1 
ATOM   3213 N N   A THR A 1 326 ? 13.62167  9.36720   -18.98234 0.908 9.02782  ? 407  THR A N   1 
ATOM   3214 N N   B THR A 1 326 ? 13.68828  10.02970  -18.93063 0.092 12.05768 ? 407  THR A N   1 
ATOM   3215 C CA  A THR A 1 326 ? 13.56328  8.37544   -20.05913 0.908 8.75223  ? 407  THR A CA  1 
ATOM   3216 C CA  B THR A 1 326 ? 13.58717  9.05396   -20.01233 0.092 11.65227 ? 407  THR A CA  1 
ATOM   3217 C C   A THR A 1 326 ? 12.12507  7.90945   -20.28755 0.908 8.61334  ? 407  THR A C   1 
ATOM   3218 C C   B THR A 1 326 ? 12.20755  8.40932   -20.05264 0.092 9.97558  ? 407  THR A C   1 
ATOM   3219 O O   A THR A 1 326 ? 11.74090  7.56050   -21.41389 0.908 8.06014  ? 407  THR A O   1 
ATOM   3220 O O   B THR A 1 326 ? 11.75498  7.96952   -21.11558 0.092 9.00900  ? 407  THR A O   1 
ATOM   3221 C CB  A THR A 1 326 ? 14.45854  7.17709   -19.72095 0.908 8.62113  ? 407  THR A CB  1 
ATOM   3222 C CB  B THR A 1 326 ? 14.67238  7.98603   -19.85300 0.092 11.49716 ? 407  THR A CB  1 
ATOM   3223 O OG1 A THR A 1 326 ? 15.77168  7.63358   -19.37199 0.908 11.09799 ? 407  THR A OG1 1 
ATOM   3224 O OG1 B THR A 1 326 ? 15.92879  8.61770   -19.57488 0.092 11.92982 ? 407  THR A OG1 1 
ATOM   3225 C CG2 A THR A 1 326 ? 14.57888  6.22961   -20.89706 0.908 8.89409  ? 407  THR A CG2 1 
ATOM   3226 C CG2 B THR A 1 326 ? 14.80315  7.14608   -21.11558 0.092 10.46278 ? 407  THR A CG2 1 
ATOM   3227 N N   A CYS A 1 327 ? 11.31616  7.91709   -19.23058 0.908 8.56569  ? 408  CYS A N   1 
ATOM   3228 N N   B CYS A 1 327 ? 11.51946  8.35790   -18.91254 0.092 9.81769  ? 408  CYS A N   1 
ATOM   3229 C CA  A CYS A 1 327 ? 9.94253   7.43732   -19.27553 0.908 8.34784  ? 408  CYS A CA  1 
ATOM   3230 C CA  B CYS A 1 327 ? 10.19373  7.76067   -18.85249 0.092 9.12260  ? 408  CYS A CA  1 
ATOM   3231 C C   A CYS A 1 327 ? 8.96609   8.47099   -19.83109 0.908 8.48716  ? 408  CYS A C   1 
ATOM   3232 C C   B CYS A 1 327 ? 9.12487   8.63482   -19.49169 0.092 9.73103  ? 408  CYS A C   1 
ATOM   3233 O O   A CYS A 1 327 ? 7.76079   8.19439   -19.89044 0.908 9.77846  ? 408  CYS A O   1 
ATOM   3234 O O   B CYS A 1 327 ? 8.01407   8.14909   -19.73157 0.092 10.58803 ? 408  CYS A O   1 
ATOM   3235 C CB  A CYS A 1 327 ? 9.53307   6.94906   -17.88501 0.908 8.63048  ? 408  CYS A CB  1 
ATOM   3236 C CB  B CYS A 1 327 ? 9.82625   7.49894   -17.39691 0.092 9.45094  ? 408  CYS A CB  1 
ATOM   3237 S SG  A CYS A 1 327 ? 10.56288  5.55143   -17.32062 0.908 8.21997  ? 408  CYS A SG  1 
ATOM   3238 S SG  B CYS A 1 327 ? 10.35070  5.89753   -16.76440 0.092 9.23661  ? 408  CYS A SG  1 
ATOM   3239 N N   A SER A 1 328 ? 9.45442   9.64731   -20.24058 0.908 8.42194  ? 409  SER A N   1 
ATOM   3240 N N   B SER A 1 328 ? 9.42758   9.90382   -19.76432 0.092 10.02291 ? 409  SER A N   1 
ATOM   3241 C CA  A SER A 1 328 ? 8.63185   10.65974  -20.89304 0.908 9.84542  ? 409  SER A CA  1 
ATOM   3242 C CA  B SER A 1 328 ? 8.47483   10.83193  -20.35690 0.092 11.17397 ? 409  SER A CA  1 
ATOM   3243 C C   A SER A 1 328 ? 9.09062   10.95973  -22.31314 0.908 8.90204  ? 409  SER A C   1 
ATOM   3244 C C   B SER A 1 328 ? 8.89027   11.28080  -21.75395 0.092 9.95819  ? 409  SER A C   1 
ATOM   3245 O O   A SER A 1 328 ? 8.58694   11.91064  -22.92205 0.908 11.22533 ? 409  SER A O   1 
ATOM   3246 O O   B SER A 1 328 ? 8.40443   12.30607  -22.24208 0.092 10.57959 ? 409  SER A O   1 
ATOM   3247 C CB  A SER A 1 328 ? 8.60472   11.96105  -20.08462 0.908 13.70099 ? 409  SER A CB  1 
ATOM   3248 C CB  B SER A 1 328 ? 8.26234   12.03738  -19.44215 0.092 12.39927 ? 409  SER A CB  1 
ATOM   3249 O OG  A SER A 1 328 ? 7.98508   11.78249  -18.82974 0.908 14.72787 ? 409  SER A OG  1 
ATOM   3250 O OG  B SER A 1 328 ? 9.49091   12.68470  -19.16938 0.092 9.98756  ? 409  SER A OG  1 
ATOM   3251 N N   A LEU A 1 329 ? 10.02438  10.18070  -22.85645 0.908 8.78034  ? 410  LEU A N   1 
ATOM   3252 N N   B LEU A 1 329 ? 9.78312   10.53842  -22.40408 0.092 10.88220 ? 410  LEU A N   1 
ATOM   3253 C CA  A LEU A 1 329 ? 10.51868  10.40548  -24.20401 0.908 9.43941  ? 410  LEU A CA  1 
ATOM   3254 C CA  B LEU A 1 329 ? 10.15892  10.84547  -23.77120 0.092 9.78922  ? 410  LEU A CA  1 
ATOM   3255 C C   A LEU A 1 329 ? 9.43439   10.10568  -25.24377 0.908 9.18201  ? 410  LEU A C   1 
ATOM   3256 C C   B LEU A 1 329 ? 8.98136   10.58172  -24.70798 0.092 10.03093 ? 410  LEU A C   1 
ATOM   3257 O O   A LEU A 1 329 ? 8.43052   9.45133   -24.94201 0.908 8.81131  ? 410  LEU A O   1 
ATOM   3258 O O   B LEU A 1 329 ? 8.04824   9.85642   -24.35618 0.092 10.53118 ? 410  LEU A O   1 
ATOM   3259 C CB  A LEU A 1 329 ? 11.74586  9.53142   -24.44724 0.908 8.96817  ? 410  LEU A CB  1 
ATOM   3260 C CB  B LEU A 1 329 ? 11.35681  9.99499   -24.18647 0.092 9.53693  ? 410  LEU A CB  1 
ATOM   3261 C CG  A LEU A 1 329 ? 13.00416  9.91022   -23.66285 0.908 10.28487 ? 410  LEU A CG  1 
ATOM   3262 C CG  B LEU A 1 329 ? 12.63841  10.18310  -23.37527 0.092 10.03027 ? 410  LEU A CG  1 
ATOM   3263 C CD1 A LEU A 1 329 ? 14.07080  8.84291   -23.81967 0.908 10.13311 ? 410  LEU A CD1 1 
ATOM   3264 C CD1 B LEU A 1 329 ? 13.71342  9.23357   -23.86787 0.092 10.72629 ? 410  LEU A CD1 1 
ATOM   3265 C CD2 A LEU A 1 329 ? 13.52876  11.26383  -24.13233 0.908 11.33460 ? 410  LEU A CD2 1 
ATOM   3266 C CD2 B LEU A 1 329 ? 13.11626  11.62521  -23.44749 0.092 10.19141 ? 410  LEU A CD2 1 
ATOM   3267 N N   A PRO A 1 330 ? 9.61618   10.58552  -26.48262 0.908 9.45905  ? 411  PRO A N   1 
ATOM   3268 N N   B PRO A 1 330 ? 8.99584   11.17119  -25.90829 0.092 9.48672  ? 411  PRO A N   1 
ATOM   3269 C CA  A PRO A 1 330 ? 8.55537   10.41284  -27.48721 0.908 9.73451  ? 411  PRO A CA  1 
ATOM   3270 C CA  B PRO A 1 330 ? 7.88781   10.93554  -26.84956 0.092 11.58016 ? 411  PRO A CA  1 
ATOM   3271 C C   A PRO A 1 330 ? 8.20760   8.96930   -27.78709 0.908 10.84485 ? 411  PRO A C   1 
ATOM   3272 C C   B PRO A 1 330 ? 7.70127   9.47791   -27.23639 0.092 10.79782 ? 411  PRO A C   1 
ATOM   3273 O O   A PRO A 1 330 ? 7.07956   8.70356   -28.22602 0.908 12.64448 ? 411  PRO A O   1 
ATOM   3274 O O   B PRO A 1 330 ? 6.60364   9.10698   -27.66900 0.092 9.70571  ? 411  PRO A O   1 
ATOM   3275 C CB  A PRO A 1 330 ? 9.11049   11.14147  -28.71946 0.908 10.77210 ? 411  PRO A CB  1 
ATOM   3276 C CB  B PRO A 1 330 ? 8.25889   11.80200  -28.06308 0.092 12.27349 ? 411  PRO A CB  1 
ATOM   3277 C CG  A PRO A 1 330 ? 10.03264  12.15665  -28.16328 0.908 11.09145 ? 411  PRO A CG  1 
ATOM   3278 C CG  B PRO A 1 330 ? 9.72953   12.05305  -27.92242 0.092 12.59978 ? 411  PRO A CG  1 
ATOM   3279 C CD  A PRO A 1 330 ? 10.66743  11.50322  -26.96499 0.908 9.21968  ? 411  PRO A CD  1 
ATOM   3280 C CD  B PRO A 1 330 ? 9.96625   12.13928  -26.44728 0.092 11.69067 ? 411  PRO A CD  1 
ATOM   3281 N N   A ASP A 1 331 ? 9.12858   8.03165   -27.56338 0.908 8.95968  ? 412  ASP A N   1 
ATOM   3282 N N   B ASP A 1 331 ? 8.72515   8.64018   -27.09321 0.092 9.10384  ? 412  ASP A N   1 
ATOM   3283 C CA  A ASP A 1 331 ? 8.87192   6.62095   -27.80559 0.908 9.72412  ? 412  ASP A CA  1 
ATOM   3284 C CA  B ASP A 1 331 ? 8.62195   7.22785   -27.43668 0.092 9.29755  ? 412  ASP A CA  1 
ATOM   3285 C C   A ASP A 1 331 ? 8.45691   5.86619   -26.55033 0.908 8.68554  ? 412  ASP A C   1 
ATOM   3286 C C   B ASP A 1 331 ? 8.10528   6.36560   -26.29123 0.092 9.85134  ? 412  ASP A C   1 
ATOM   3287 O O   A ASP A 1 331 ? 8.35504   4.63615   -26.58762 0.908 11.07517 ? 412  ASP A O   1 
ATOM   3288 O O   B ASP A 1 331 ? 8.01288   5.14367   -26.44793 0.092 9.44407  ? 412  ASP A O   1 
ATOM   3289 C CB  A ASP A 1 331 ? 10.06324  5.95458   -28.49798 0.908 9.48999  ? 412  ASP A CB  1 
ATOM   3290 C CB  B ASP A 1 331 ? 9.97206   6.69865   -27.93878 0.092 9.79995  ? 412  ASP A CB  1 
ATOM   3291 C CG  A ASP A 1 331 ? 11.38681  6.19483   -27.79120 0.908 8.47188  ? 412  ASP A CG  1 
ATOM   3292 C CG  B ASP A 1 331 ? 10.91535  6.32203   -26.80821 0.092 11.15739 ? 412  ASP A CG  1 
ATOM   3293 O OD1 A ASP A 1 331 ? 11.42876  6.82255   -26.71365 0.908 9.76126  ? 412  ASP A OD1 1 
ATOM   3294 O OD1 B ASP A 1 331 ? 10.90394  7.00084   -25.75820 0.092 11.19654 ? 412  ASP A OD1 1 
ATOM   3295 O OD2 A ASP A 1 331 ? 12.39688  5.73738   -28.36681 0.908 9.46423  ? 412  ASP A OD2 1 
ATOM   3296 O OD2 B ASP A 1 331 ? 11.67695  5.34641   -26.97546 0.092 10.66576 ? 412  ASP A OD2 1 
ATOM   3297 N N   A ALA A 1 332 ? 8.18618   6.57127   -25.45462 0.908 8.65014  ? 413  ALA A N   1 
ATOM   3298 N N   B ALA A 1 332 ? 7.76597   6.96399   -25.15421 0.092 9.37717  ? 413  ALA A N   1 
ATOM   3299 C CA  A ALA A 1 332 ? 7.72226   5.95535   -24.21729 0.908 8.20160  ? 413  ALA A CA  1 
ATOM   3300 C CA  B ALA A 1 332 ? 7.30774   6.22463   -23.98818 0.092 9.37596  ? 413  ALA A CA  1 
ATOM   3301 C C   A ALA A 1 332 ? 6.21231   6.10908   -24.09503 0.908 8.57269  ? 413  ALA A C   1 
ATOM   3302 C C   B ALA A 1 332 ? 5.78624   6.17781   -23.95899 0.092 10.87562 ? 413  ALA A C   1 
ATOM   3303 O O   A ALA A 1 332 ? 5.67201   7.20522   -24.29441 0.908 9.16918  ? 413  ALA A O   1 
ATOM   3304 O O   B ALA A 1 332 ? 5.11718   7.17353   -24.25100 0.092 12.22034 ? 413  ALA A O   1 
ATOM   3305 C CB  A ALA A 1 332 ? 8.38878   6.60254   -23.00511 0.908 8.64491  ? 413  ALA A CB  1 
ATOM   3306 C CB  B ALA A 1 332 ? 7.82887   6.86917   -22.70327 0.092 10.70662 ? 413  ALA A CB  1 
ATOM   3307 N N   A ALA A 1 333 ? 5.53872   5.01335   -23.74888 0.908 8.57053  ? 414  ALA A N   1 
ATOM   3308 N N   B ALA A 1 333 ? 5.24653   5.01230   -23.61015 0.092 10.20672 ? 414  ALA A N   1 
ATOM   3309 C CA  A ALA A 1 333 ? 4.09368   5.03622   -23.56003 0.908 8.98448  ? 414  ALA A CA  1 
ATOM   3310 C CA  B ALA A 1 333 ? 3.80250   4.83056   -23.48216 0.092 10.35675 ? 414  ALA A CA  1 
ATOM   3311 C C   A ALA A 1 333 ? 3.74043   5.84053   -22.31492 0.908 9.45686  ? 414  ALA A C   1 
ATOM   3312 C C   B ALA A 1 333 ? 3.33415   5.59128   -22.25005 0.092 11.35358 ? 414  ALA A C   1 
ATOM   3313 O O   A ALA A 1 333 ? 4.28256   5.60108   -21.23307 0.908 10.74284 ? 414  ALA A O   1 
ATOM   3314 O O   B ALA A 1 333 ? 3.43645   5.10308   -21.12288 0.092 12.56081 ? 414  ALA A O   1 
ATOM   3315 C CB  A ALA A 1 333 ? 3.57095   3.60719   -23.42893 0.908 10.42089 ? 414  ALA A CB  1 
ATOM   3316 C CB  B ALA A 1 333 ? 3.46654   3.34782   -23.37445 0.092 10.91235 ? 414  ALA A CB  1 
ATOM   3317 N N   . GLN A 1 334 ? 2.81911   6.79632   -22.46298 1.000 10.18472 ? 415  GLN A N   1 
ATOM   3318 C CA  . GLN A 1 334 ? 2.43573   7.70272   -21.38780 1.000 11.04369 ? 415  GLN A CA  1 
ATOM   3319 C C   . GLN A 1 334 ? 0.93453   7.92371   -21.39792 1.000 10.78114 ? 415  GLN A C   1 
ATOM   3320 O O   . GLN A 1 334 ? 0.33608   8.03713   -22.47538 1.000 14.03771 ? 415  GLN A O   1 
ATOM   3321 C CB  . GLN A 1 334 ? 3.10980   9.07014   -21.55190 1.000 11.89171 ? 415  GLN A CB  1 
ATOM   3322 C CG  . GLN A 1 334 ? 4.61645   9.00595   -21.59728 1.000 11.02676 ? 415  GLN A CG  1 
ATOM   3323 C CD  . GLN A 1 334 ? 5.24732   10.22274  -22.25376 1.000 11.72721 ? 415  GLN A CD  1 
ATOM   3324 O OE1 . GLN A 1 334 ? 5.05140   11.35754  -21.81738 1.000 13.83839 ? 415  GLN A OE1 1 
ATOM   3325 N NE2 . GLN A 1 334 ? 6.01372   9.98753   -23.30962 1.000 12.32855 ? 415  GLN A NE2 1 
ATOM   3326 N N   . PRO A 1 335 ? 0.30142   8.04471   -20.22154 1.000 9.74327  ? 416  PRO A N   1 
ATOM   3327 C CA  . PRO A 1 335 ? 0.90582   7.93570   -18.88678 1.000 9.41574  ? 416  PRO A CA  1 
ATOM   3328 C C   . PRO A 1 335 ? 1.24180   6.49424   -18.52257 1.000 8.75282  ? 416  PRO A C   1 
ATOM   3329 O O   . PRO A 1 335 ? 0.54534   5.57056   -18.94395 1.000 10.82070 ? 416  PRO A O   1 
ATOM   3330 C CB  . PRO A 1 335 ? -0.19646  8.45503   -17.96077 1.000 10.84692 ? 416  PRO A CB  1 
ATOM   3331 C CG  . PRO A 1 335 ? -1.46890  8.19910   -18.70891 1.000 13.08010 ? 416  PRO A CG  1 
ATOM   3332 C CD  . PRO A 1 335 ? -1.12483  8.41398   -20.15221 1.000 11.28838 ? 416  PRO A CD  1 
ATOM   3333 N N   . ALA A 1 336 ? 2.30491   6.31215   -17.74063 1.000 8.53211  ? 417  ALA A N   1 
ATOM   3334 C CA  . ALA A 1 336 ? 2.75940   5.01680   -17.29738 1.000 8.69703  ? 417  ALA A CA  1 
ATOM   3335 C C   . ALA A 1 336 ? 2.85204   4.99212   -15.77915 1.000 7.89248  ? 417  ALA A C   1 
ATOM   3336 O O   . ALA A 1 336 ? 3.23917   5.99187   -15.15909 1.000 9.08330  ? 417  ALA A O   1 
ATOM   3337 C CB  . ALA A 1 336 ? 4.13682   4.68873   -17.88838 1.000 9.33639  ? 417  ALA A CB  1 
ATOM   3338 N N   . PRO A 1 337 ? 2.52488   3.85793   -15.16037 1.000 8.73152  ? 418  PRO A N   1 
ATOM   3339 C CA  . PRO A 1 337 ? 2.55543   3.75584   -13.70117 1.000 9.04639  ? 418  PRO A CA  1 
ATOM   3340 C C   . PRO A 1 337 ? 3.93270   3.37101   -13.17331 1.000 8.57820  ? 418  PRO A C   1 
ATOM   3341 O O   . PRO A 1 337 ? 4.87240   3.13388   -13.93946 1.000 8.10220  ? 418  PRO A O   1 
ATOM   3342 C CB  . PRO A 1 337 ? 1.52129   2.65457   -13.43502 1.000 9.40670  ? 418  PRO A CB  1 
ATOM   3343 C CG  . PRO A 1 337 ? 1.72130   1.72088   -14.59593 1.000 9.87536  ? 418  PRO A CG  1 
ATOM   3344 C CD  . PRO A 1 337 ? 2.06425   2.60692   -15.78531 1.000 9.13507  ? 418  PRO A CD  1 
ATOM   3345 N N   . GLU A 1 338 ? 4.04550   3.29897   -11.84914 1.000 8.62532  ? 419  GLU A N   1 
ATOM   3346 C CA  . GLU A 1 338 ? 5.31448   3.00233   -11.19561 1.000 7.96756  ? 419  GLU A CA  1 
ATOM   3347 C C   . GLU A 1 338 ? 5.90932   1.68965   -11.68422 1.000 7.75526  ? 419  GLU A C   1 
ATOM   3348 O O   . GLU A 1 338 ? 5.19120   0.72276   -11.96209 1.000 8.00892  ? 419  GLU A O   1 
ATOM   3349 C CB  . GLU A 1 338 ? 5.09652   2.92382   -9.68939  1.000 8.61595  ? 419  GLU A CB  1 
ATOM   3350 C CG  . GLU A 1 338 ? 4.90385   4.28401   -9.03420  1.000 9.73079  ? 419  GLU A CG  1 
ATOM   3351 C CD  . GLU A 1 338 ? 6.20372   5.07083   -8.89870  1.000 9.86657  ? 419  GLU A CD  1 
ATOM   3352 O OE1 . GLU A 1 338 ? 7.30485   4.50261   -9.09738  1.000 9.78256  ? 419  GLU A OE1 1 
ATOM   3353 O OE2 . GLU A 1 338 ? 6.10395   6.28518   -8.60508  1.000 12.86975 ? 419  GLU A OE2 1 
ATOM   3354 N N   . ALA A 1 339 ? 7.24031   1.65878   -11.76254 1.000 8.04000  ? 420  ALA A N   1 
ATOM   3355 C CA  . ALA A 1 339 ? 7.94757   0.46670   -12.20115 1.000 7.20601  ? 420  ALA A CA  1 
ATOM   3356 C C   . ALA A 1 339 ? 7.48894   -0.74930  -11.41505 1.000 7.41046  ? 420  ALA A C   1 
ATOM   3357 O O   . ALA A 1 339 ? 7.34623   -0.70249  -10.18971 1.000 8.46013  ? 420  ALA A O   1 
ATOM   3358 C CB  . ALA A 1 339 ? 9.45586   0.65571   -12.01226 1.000 8.39916  ? 420  ALA A CB  1 
ATOM   3359 N N   . GLY A 1 340 ? 7.27463   -1.84333  -12.14314 1.000 7.95614  ? 421  GLY A N   1 
ATOM   3360 C CA  . GLY A 1 340 ? 6.85018   -3.09597  -11.57798 1.000 7.99471  ? 421  GLY A CA  1 
ATOM   3361 C C   . GLY A 1 340 ? 5.35500   -3.26079  -11.47778 1.000 9.10849  ? 421  GLY A C   1 
ATOM   3362 O O   . GLY A 1 340 ? 4.87507   -4.39989  -11.41907 1.000 11.27898 ? 421  GLY A O   1 
ATOM   3363 N N   . THR A 1 341 ? 4.60509   -2.16671  -11.46962 1.000 8.41771  ? 422  THR A N   1 
ATOM   3364 C CA  . THR A 1 341 ? 3.15855   -2.27381  -11.36609 1.000 8.50354  ? 422  THR A CA  1 
ATOM   3365 C C   . THR A 1 341 ? 2.52086   -2.48302  -12.74049 1.000 7.85329  ? 422  THR A C   1 
ATOM   3366 O O   . THR A 1 341 ? 3.10466   -2.17955  -13.78438 1.000 8.35811  ? 422  THR A O   1 
ATOM   3367 C CB  . THR A 1 341 ? 2.54471   -1.06625  -10.64833 1.000 9.90190  ? 422  THR A CB  1 
ATOM   3368 O OG1 . THR A 1 341 ? 2.53931   0.07795   -11.50744 1.000 9.78533  ? 422  THR A OG1 1 
ATOM   3369 C CG2 . THR A 1 341 ? 3.28868   -0.74533  -9.35076  1.000 11.31161 ? 422  THR A CG2 1 
ATOM   3370 N N   . TRP A 1 342 ? 1.30347   -3.02241  -12.72999 1.000 8.17900  ? 423  TRP A N   1 
ATOM   3371 C CA  . TRP A 1 342 ? 0.67417   -3.44605  -13.97229 1.000 8.19100  ? 423  TRP A CA  1 
ATOM   3372 C C   . TRP A 1 342 ? 0.27718   -2.25628  -14.83859 1.000 7.09126  ? 423  TRP A C   1 
ATOM   3373 O O   . TRP A 1 342 ? -0.31174  -1.28572  -14.35777 1.000 8.66336  ? 423  TRP A O   1 
ATOM   3374 C CB  . TRP A 1 342 ? -0.55711  -4.29718  -13.67579 1.000 9.15240  ? 423  TRP A CB  1 
ATOM   3375 C CG  . TRP A 1 342 ? -1.03923  -5.02838  -14.88285 1.000 8.55018  ? 423  TRP A CG  1 
ATOM   3376 C CD1 . TRP A 1 342 ? -2.19953  -4.81295  -15.58052 1.000 8.33240  ? 423  TRP A CD1 1 
ATOM   3377 C CD2 . TRP A 1 342 ? -0.36017  -6.08683  -15.55527 1.000 7.67991  ? 423  TRP A CD2 1 
ATOM   3378 N NE1 . TRP A 1 342 ? -2.27565  -5.67920  -16.64679 1.000 9.02291  ? 423  TRP A NE1 1 
ATOM   3379 C CE2 . TRP A 1 342 ? -1.15837  -6.47618  -16.64978 1.000 8.25602  ? 423  TRP A CE2 1 
ATOM   3380 C CE3 . TRP A 1 342 ? 0.85343   -6.74640  -15.33731 1.000 8.23347  ? 423  TRP A CE3 1 
ATOM   3381 C CZ2 . TRP A 1 342 ? -0.78218  -7.50712  -17.51535 1.000 8.41702  ? 423  TRP A CZ2 1 
ATOM   3382 C CZ3 . TRP A 1 342 ? 1.22853   -7.75831  -16.19624 1.000 8.20203  ? 423  TRP A CZ3 1 
ATOM   3383 C CH2 . TRP A 1 342 ? 0.41641   -8.12981  -17.27234 1.000 8.50236  ? 423  TRP A CH2 1 
ATOM   3384 N N   . PHE A 1 343 ? 0.55013   -2.36501  -16.13239 1.000 7.76339  ? 424  PHE A N   1 
ATOM   3385 C CA  . PHE A 1 343 ? 0.29211   -1.31910  -17.12415 1.000 7.86563  ? 424  PHE A CA  1 
ATOM   3386 C C   . PHE A 1 343 ? -0.58747  -1.96386  -18.19645 1.000 7.53699  ? 424  PHE A C   1 
ATOM   3387 O O   . PHE A 1 343 ? -0.09994  -2.48917  -19.19819 1.000 7.84461  ? 424  PHE A O   1 
ATOM   3388 C CB  . PHE A 1 343 ? 1.64530   -0.87140  -17.66239 1.000 8.37693  ? 424  PHE A CB  1 
ATOM   3389 C CG  . PHE A 1 343 ? 1.62490   0.36103   -18.53419 1.000 8.09778  ? 424  PHE A CG  1 
ATOM   3390 C CD1 . PHE A 1 343 ? 0.44987   0.96632   -18.95295 1.000 9.29799  ? 424  PHE A CD1 1 
ATOM   3391 C CD2 . PHE A 1 343 ? 2.82825   0.89413   -18.96491 1.000 9.34593  ? 424  PHE A CD2 1 
ATOM   3392 C CE1 . PHE A 1 343 ? 0.48750   2.09998   -19.77207 1.000 9.67092  ? 424  PHE A CE1 1 
ATOM   3393 C CE2 . PHE A 1 343 ? 2.86980   2.01638   -19.77982 1.000 9.62140  ? 424  PHE A CE2 1 
ATOM   3394 C CZ  . PHE A 1 343 ? 1.69854   2.62128   -20.18907 1.000 10.24349 ? 424  PHE A CZ  1 
ATOM   3395 N N   . GLN A 1 344 ? -1.90341  -1.92508  -17.96673 1.000 8.19021  ? 425  GLN A N   1 
ATOM   3396 C CA  . GLN A 1 344 ? -2.84860  -2.71348  -18.75699 1.000 8.32320  ? 425  GLN A CA  1 
ATOM   3397 C C   . GLN A 1 344 ? -2.77129  -2.39763  -20.24911 1.000 8.04588  ? 425  GLN A C   1 
ATOM   3398 O O   . GLN A 1 344 ? -2.75260  -3.30781  -21.08426 1.000 9.03100  ? 425  GLN A O   1 
ATOM   3399 C CB  . GLN A 1 344 ? -4.26969  -2.48487  -18.23820 1.000 8.99597  ? 425  GLN A CB  1 
ATOM   3400 C CG  . GLN A 1 344 ? -5.35200  -3.14532  -19.08382 1.000 8.86878  ? 425  GLN A CG  1 
ATOM   3401 C CD  . GLN A 1 344 ? -5.36287  -4.66208  -18.97097 1.000 8.72816  ? 425  GLN A CD  1 
ATOM   3402 O OE1 . GLN A 1 344 ? -4.77767  -5.23960  -18.04811 1.000 9.68438  ? 425  GLN A OE1 1 
ATOM   3403 N NE2 . GLN A 1 344 ? -6.03951  -5.31661  -19.91603 1.000 9.90776  ? 425  GLN A NE2 1 
ATOM   3404 N N   . ALA A 1 345 ? -2.78043  -1.11189  -20.61120 1.000 8.78474  ? 426  ALA A N   1 
ATOM   3405 C CA  . ALA A 1 345 ? -2.79648  -0.75916  -22.02910 1.000 9.68116  ? 426  ALA A CA  1 
ATOM   3406 C C   . ALA A 1 345 ? -1.53075  -1.22989  -22.72662 1.000 9.24288  ? 426  ALA A C   1 
ATOM   3407 O O   . ALA A 1 345 ? -1.56491  -1.60914  -23.90496 1.000 10.59539 ? 426  ALA A O   1 
ATOM   3408 C CB  . ALA A 1 345 ? -2.96530  0.74724   -22.20247 1.000 11.22301 ? 426  ALA A CB  1 
ATOM   3409 N N   . TYR A 1 346 ? -0.41284  -1.23489  -22.00210 1.000 8.29368  ? 427  TYR A N   1 
ATOM   3410 C CA  . TYR A 1 346 ? 0.85422   -1.68405  -22.56434 1.000 8.06808  ? 427  TYR A CA  1 
ATOM   3411 C C   . TYR A 1 346 ? 0.84822   -3.18979  -22.78856 1.000 7.94726  ? 427  TYR A C   1 
ATOM   3412 O O   . TYR A 1 346 ? 1.31099   -3.67506  -23.82903 1.000 8.42698  ? 427  TYR A O   1 
ATOM   3413 C CB  . TYR A 1 346 ? 1.98651   -1.26332  -21.62871 1.000 8.30475  ? 427  TYR A CB  1 
ATOM   3414 C CG  . TYR A 1 346 ? 3.34136   -1.37489  -22.27572 1.000 8.00569  ? 427  TYR A CG  1 
ATOM   3415 C CD1 . TYR A 1 346 ? 4.02949   -2.58370  -22.29211 1.000 7.90991  ? 427  TYR A CD1 1 
ATOM   3416 C CD2 . TYR A 1 346 ? 3.90830   -0.28823  -22.92851 1.000 8.28129  ? 427  TYR A CD2 1 
ATOM   3417 C CE1 . TYR A 1 346 ? 5.26568   -2.69305  -22.91297 1.000 8.36034  ? 427  TYR A CE1 1 
ATOM   3418 C CE2 . TYR A 1 346 ? 5.13559   -0.38799  -23.55219 1.000 8.40586  ? 427  TYR A CE2 1 
ATOM   3419 C CZ  . TYR A 1 346 ? 5.80945   -1.58934  -23.54416 1.000 8.35792  ? 427  TYR A CZ  1 
ATOM   3420 O OH  . TYR A 1 346 ? 7.03392   -1.70047  -24.16209 1.000 8.23076  ? 427  TYR A OH  1 
ATOM   3421 N N   . PHE A 1 347 ? 0.29540   -3.93754  -21.82984 1.000 7.56582  ? 428  PHE A N   1 
ATOM   3422 C CA  . PHE A 1 347 ? 0.14637   -5.37867  -21.99034 1.000 8.31091  ? 428  PHE A CA  1 
ATOM   3423 C C   . PHE A 1 347 ? -0.70428  -5.70762  -23.20301 1.000 7.92939  ? 428  PHE A C   1 
ATOM   3424 O O   . PHE A 1 347 ? -0.36704  -6.59521  -23.99316 1.000 8.31094  ? 428  PHE A O   1 
ATOM   3425 C CB  . PHE A 1 347 ? -0.48213  -5.98600  -20.73944 1.000 7.68926  ? 428  PHE A CB  1 
ATOM   3426 C CG  . PHE A 1 347 ? -0.82703  -7.43966  -20.88939 1.000 8.23334  ? 428  PHE A CG  1 
ATOM   3427 C CD1 . PHE A 1 347 ? 0.16833   -8.40722  -20.86805 1.000 8.61504  ? 428  PHE A CD1 1 
ATOM   3428 C CD2 . PHE A 1 347 ? -2.14576  -7.84248  -21.06302 1.000 8.06247  ? 428  PHE A CD2 1 
ATOM   3429 C CE1 . PHE A 1 347 ? -0.14237  -9.74683  -21.00144 1.000 8.66678  ? 428  PHE A CE1 1 
ATOM   3430 C CE2 . PHE A 1 347 ? -2.45818  -9.18909  -21.19989 1.000 8.74537  ? 428  PHE A CE2 1 
ATOM   3431 C CZ  . PHE A 1 347 ? -1.46149  -10.13870 -21.16807 1.000 9.33947  ? 428  PHE A CZ  1 
ATOM   3432 N N   . GLN A 1 348 ? -1.82839  -5.01549  -23.36499 1.000 8.71988  ? 429  GLN A N   1 
ATOM   3433 C CA  A GLN A 1 348 ? -2.70164  -5.31475  -24.49165 0.789 9.34821  ? 429  GLN A CA  1 
ATOM   3434 C CA  B GLN A 1 348 ? -2.67942  -5.36944  -24.48944 0.211 9.31769  ? 429  GLN A CA  1 
ATOM   3435 C C   . GLN A 1 348 ? -1.97756  -5.12793  -25.81797 1.000 9.41147  ? 429  GLN A C   1 
ATOM   3436 O O   . GLN A 1 348 ? -2.14126  -5.92533  -26.74526 1.000 9.53763  ? 429  GLN A O   1 
ATOM   3437 C CB  A GLN A 1 348 ? -3.94940  -4.44242  -24.44625 0.789 10.85803 ? 429  GLN A CB  1 
ATOM   3438 C CB  B GLN A 1 348 ? -4.08005  -4.75894  -24.39632 0.211 11.34949 ? 429  GLN A CB  1 
ATOM   3439 C CG  A GLN A 1 348 ? -4.90547  -4.84288  -25.53908 0.789 10.00442 ? 429  GLN A CG  1 
ATOM   3440 C CG  B GLN A 1 348 ? -4.15514  -3.33325  -23.95427 0.211 12.48620 ? 429  GLN A CG  1 
ATOM   3441 C CD  A GLN A 1 348 ? -6.20712  -4.10832  -25.49371 0.789 9.59155  ? 429  GLN A CD  1 
ATOM   3442 C CD  B GLN A 1 348 ? -5.47415  -2.68849  -24.32516 0.211 17.22344 ? 429  GLN A CD  1 
ATOM   3443 O OE1 A GLN A 1 348 ? -6.94420  -4.18437  -24.51699 0.789 11.28927 ? 429  GLN A OE1 1 
ATOM   3444 O OE1 B GLN A 1 348 ? -6.47094  -3.37532  -24.54304 0.211 14.61481 ? 429  GLN A OE1 1 
ATOM   3445 N NE2 A GLN A 1 348 ? -6.51515  -3.39692  -26.56947 0.789 17.51617 ? 429  GLN A NE2 1 
ATOM   3446 N NE2 B GLN A 1 348 ? -5.49513  -1.36085  -24.36844 0.211 17.26062 ? 429  GLN A NE2 1 
ATOM   3447 N N   . THR A 1 349 ? -1.15383  -4.07730  -25.91734 1.000 8.60951  ? 430  THR A N   1 
ATOM   3448 C CA  . THR A 1 349 ? -0.38248  -3.88127  -27.13972 1.000 8.85438  ? 430  THR A CA  1 
ATOM   3449 C C   . THR A 1 349 ? 0.67526   -4.96594  -27.32002 1.000 7.35730  ? 430  THR A C   1 
ATOM   3450 O O   . THR A 1 349 ? 0.89058   -5.43784  -28.43839 1.000 8.76323  ? 430  THR A O   1 
ATOM   3451 C CB  . THR A 1 349 ? 0.21911   -2.48060  -27.16668 1.000 8.91524  ? 430  THR A CB  1 
ATOM   3452 O OG1 . THR A 1 349 ? -0.84512  -1.52748  -27.16629 1.000 10.56580 ? 430  THR A OG1 1 
ATOM   3453 C CG2 . THR A 1 349 ? 1.07912   -2.28203  -28.40603 1.000 10.63757 ? 430  THR A CG2 1 
ATOM   3454 N N   . LEU A 1 350 ? 1.34036   -5.38357  -26.23620 1.000 7.44883  ? 431  LEU A N   1 
ATOM   3455 C CA  . LEU A 1 350 ? 2.30441   -6.47962  -26.34729 1.000 7.47765  ? 431  LEU A CA  1 
ATOM   3456 C C   . LEU A 1 350 ? 1.65757   -7.72654  -26.93891 1.000 7.61812  ? 431  LEU A C   1 
ATOM   3457 O O   . LEU A 1 350 ? 2.26988   -8.43089  -27.75260 1.000 8.11096  ? 431  LEU A O   1 
ATOM   3458 C CB  . LEU A 1 350 ? 2.89112   -6.81608  -24.97806 1.000 8.20747  ? 431  LEU A CB  1 
ATOM   3459 C CG  . LEU A 1 350 ? 3.97748   -5.91159  -24.40787 1.000 8.13902  ? 431  LEU A CG  1 
ATOM   3460 C CD1 . LEU A 1 350 ? 4.19552   -6.24985  -22.95522 1.000 8.15490  ? 431  LEU A CD1 1 
ATOM   3461 C CD2 . LEU A 1 350 ? 5.27609   -6.05340  -25.19631 1.000 8.03520  ? 431  LEU A CD2 1 
ATOM   3462 N N   A VAL A 1 351 ? 0.42548   -8.02236  -26.51222 0.789 7.94978  ? 432  VAL A N   1 
ATOM   3463 N N   B VAL A 1 351 ? 0.41698   -8.01467  -26.53782 0.211 8.01251  ? 432  VAL A N   1 
ATOM   3464 C CA  A VAL A 1 351 ? -0.32335  -9.15712  -27.05039 0.789 8.26316  ? 432  VAL A CA  1 
ATOM   3465 C CA  B VAL A 1 351 ? -0.29912  -9.17138  -27.06891 0.211 8.30081  ? 432  VAL A CA  1 
ATOM   3466 C C   A VAL A 1 351 ? -0.60980  -8.94856  -28.52662 0.789 8.68843  ? 432  VAL A C   1 
ATOM   3467 C C   B VAL A 1 351 ? -0.66580  -8.94799  -28.52984 0.211 8.70439  ? 432  VAL A C   1 
ATOM   3468 O O   A VAL A 1 351 ? -0.33673  -9.81671  -29.36183 0.789 8.95212  ? 432  VAL A O   1 
ATOM   3469 O O   B VAL A 1 351 ? -0.43769  -9.81219  -29.38355 0.211 8.94529  ? 432  VAL A O   1 
ATOM   3470 C CB  A VAL A 1 351 ? -1.63008  -9.36827  -26.26197 0.789 8.16009  ? 432  VAL A CB  1 
ATOM   3471 C CB  B VAL A 1 351 ? -1.54023  -9.47625  -26.21048 0.211 8.32980  ? 432  VAL A CB  1 
ATOM   3472 C CG1 A VAL A 1 351 ? -2.44139  -10.49183 -26.88602 0.789 10.18357 ? 432  VAL A CG1 1 
ATOM   3473 C CG1 B VAL A 1 351 ? -2.36442  -10.59067 -26.83942 0.211 10.04070 ? 432  VAL A CG1 1 
ATOM   3474 C CG2 A VAL A 1 351 ? -1.34281  -9.66562  -24.79839 0.789 8.74951  ? 432  VAL A CG2 1 
ATOM   3475 C CG2 B VAL A 1 351 ? -1.13184  -9.83648  -24.79197 0.211 9.23541  ? 432  VAL A CG2 1 
ATOM   3476 N N   A SER A 1 352 ? -1.17711  -7.79242  -28.86419 0.789 8.77031  ? 433  SER A N   1 
ATOM   3477 N N   B SER A 1 352 ? -1.24552  -7.78638  -28.83751 0.211 8.87260  ? 433  SER A N   1 
ATOM   3478 C CA  A SER A 1 352 ? -1.58568  -7.53014  -30.23699 0.789 9.26452  ? 433  SER A CA  1 
ATOM   3479 C CA  B SER A 1 352 ? -1.65878  -7.50305  -30.20806 0.211 9.33932  ? 433  SER A CA  1 
ATOM   3480 C C   A SER A 1 352 ? -0.40674  -7.59958  -31.19624 0.789 8.86868  ? 433  SER A C   1 
ATOM   3481 C C   B SER A 1 352 ? -0.45440  -7.43202  -31.13556 0.211 9.50478  ? 433  SER A C   1 
ATOM   3482 O O   A SER A 1 352 ? -0.56075  -8.05218  -32.33864 0.789 11.02476 ? 433  SER A O   1 
ATOM   3483 O O   B SER A 1 352 ? -0.42040  -8.08509  -32.18589 0.211 12.23825 ? 433  SER A O   1 
ATOM   3484 C CB  A SER A 1 352 ? -2.24029  -6.15420  -30.30231 0.789 10.47517 ? 433  SER A CB  1 
ATOM   3485 C CB  B SER A 1 352 ? -2.43889  -6.19063  -30.25113 0.211 10.83242 ? 433  SER A CB  1 
ATOM   3486 O OG  A SER A 1 352 ? -2.79115  -5.90371  -31.58104 0.789 12.86543 ? 433  SER A OG  1 
ATOM   3487 O OG  B SER A 1 352 ? -1.55968  -5.08396  -30.15726 0.211 14.85621 ? 433  SER A OG  1 
ATOM   3488 N N   A ALA A 1 353 ? 0.76852   -7.16037  -30.75295 0.789 7.95455  ? 434  ALA A N   1 
ATOM   3489 N N   B ALA A 1 353 ? 0.54613   -6.64194  -30.76141 0.211 6.52847  ? 434  ALA A N   1 
ATOM   3490 C CA  A ALA A 1 353 ? 1.94492   -7.03499  -31.60182 0.789 8.90148  ? 434  ALA A CA  1 
ATOM   3491 C CA  B ALA A 1 353 ? 1.74446   -6.48005  -31.57097 0.211 9.81282  ? 434  ALA A CA  1 
ATOM   3492 C C   A ALA A 1 353 ? 2.89583   -8.21990  -31.49665 0.789 7.65445  ? 434  ALA A C   1 
ATOM   3493 C C   B ALA A 1 353 ? 2.72312   -7.63303  -31.42210 0.211 9.03368  ? 434  ALA A C   1 
ATOM   3494 O O   A ALA A 1 353 ? 3.99864   -8.15995  -32.04975 0.789 8.29267  ? 434  ALA A O   1 
ATOM   3495 O O   B ALA A 1 353 ? 3.85768   -7.51691  -31.89491 0.211 8.60509  ? 434  ALA A O   1 
ATOM   3496 C CB  A ALA A 1 353 ? 2.67847   -5.73178  -31.28480 0.789 9.56211  ? 434  ALA A CB  1 
ATOM   3497 C CB  B ALA A 1 353 ? 2.43726   -5.15665  -31.23754 0.211 9.91239  ? 434  ALA A CB  1 
ATOM   3498 N N   A ALA A 1 354 ? 2.49061   -9.29322  -30.82110 0.789 7.99485  ? 435  ALA A N   1 
ATOM   3499 N N   B ALA A 1 354 ? 2.32063   -8.73051  -30.78432 0.211 9.81532  ? 435  ALA A N   1 
ATOM   3500 C CA  A ALA A 1 354 ? 3.37502   -10.43077 -30.60651 0.789 8.34912  ? 435  ALA A CA  1 
ATOM   3501 C CA  B ALA A 1 354 ? 3.23284   -9.84608  -30.57438 0.211 8.61777  ? 435  ALA A CA  1 
ATOM   3502 C C   A ALA A 1 354 ? 3.89253   -10.98104 -31.92988 0.789 8.53444  ? 435  ALA A C   1 
ATOM   3503 C C   B ALA A 1 354 ? 3.69988   -10.41655 -31.90606 0.211 8.99141  ? 435  ALA A C   1 
ATOM   3504 O O   A ALA A 1 354 ? 3.15440   -11.10526 -32.91260 0.789 9.93223  ? 435  ALA A O   1 
ATOM   3505 O O   B ALA A 1 354 ? 2.89340   -10.68864 -32.80070 0.211 10.94571 ? 435  ALA A O   1 
ATOM   3506 C CB  A ALA A 1 354 ? 2.63893   -11.52991 -29.84543 0.789 9.37207  ? 435  ALA A CB  1 
ATOM   3507 C CB  B ALA A 1 354 ? 2.54604   -10.93882 -29.75669 0.211 8.63162  ? 435  ALA A CB  1 
ATOM   3508 N N   A ASN A 1 355 ? 5.17657   -11.28863 -31.95197 0.789 8.19253  ? 436  ASN A N   1 
ATOM   3509 N N   B ASN A 1 355 ? 5.01078   -10.58668 -32.03365 0.211 8.71792  ? 436  ASN A N   1 
ATOM   3510 C CA  A ASN A 1 355 ? 5.82603   -11.80706 -33.14030 0.789 9.41258  ? 436  ASN A CA  1 
ATOM   3511 C CA  B ASN A 1 355 ? 5.61869   -11.25768 -33.17348 0.211 10.82527 ? 436  ASN A CA  1 
ATOM   3512 C C   A ASN A 1 355 ? 6.84582   -12.83722 -32.68173 0.789 10.08622 ? 436  ASN A C   1 
ATOM   3513 C C   B ASN A 1 355 ? 6.72028   -12.17372 -32.65352 0.211 10.99980 ? 436  ASN A C   1 
ATOM   3514 O O   A ASN A 1 355 ? 7.86412   -12.46876 -32.08221 0.789 10.37356 ? 436  ASN A O   1 
ATOM   3515 O O   B ASN A 1 355 ? 7.75437   -11.68345 -32.18057 0.211 7.28904  ? 436  ASN A O   1 
ATOM   3516 C CB  A ASN A 1 355 ? 6.50452   -10.67064 -33.90188 0.789 11.35337 ? 436  ASN A CB  1 
ATOM   3517 C CB  B ASN A 1 355 ? 6.18952   -10.24061 -34.16002 0.211 11.75880 ? 436  ASN A CB  1 
ATOM   3518 C CG  A ASN A 1 355 ? 7.32056   -11.15990 -35.07098 0.789 14.41851 ? 436  ASN A CG  1 
ATOM   3519 C CG  B ASN A 1 355 ? 6.34843   -10.81138 -35.55578 0.211 15.92298 ? 436  ASN A CG  1 
ATOM   3520 O OD1 A ASN A 1 355 ? 7.04052   -12.21493 -35.63952 0.789 15.37379 ? 436  ASN A OD1 1 
ATOM   3521 O OD1 B ASN A 1 355 ? 5.67416   -11.77263 -35.92574 0.211 17.44978 ? 436  ASN A OD1 1 
ATOM   3522 N ND2 A ASN A 1 355 ? 8.35590   -10.40498 -35.42460 0.789 16.22567 ? 436  ASN A ND2 1 
ATOM   3523 N ND2 B ASN A 1 355 ? 7.24374   -10.22255 -36.33794 0.211 14.50054 ? 436  ASN A ND2 1 
ATOM   3524 N N   A PRO A 1 356 ? 6.60773   -14.13728 -32.91366 0.789 11.02594 ? 437  PRO A N   1 
ATOM   3525 N N   B PRO A 1 356 ? 6.55281   -13.50714 -32.71891 0.211 10.56882 ? 437  PRO A N   1 
ATOM   3526 C CA  A PRO A 1 356 ? 5.44521   -14.70395 -33.62298 0.789 13.55688 ? 437  PRO A CA  1 
ATOM   3527 C CA  B PRO A 1 356 ? 5.48830   -14.30088 -33.35307 0.211 15.57931 ? 437  PRO A CA  1 
ATOM   3528 C C   A PRO A 1 356 ? 4.10568   -14.46161 -32.90626 0.789 14.36486 ? 437  PRO A C   1 
ATOM   3529 C C   B PRO A 1 356 ? 4.09450   -14.08194 -32.76011 0.211 13.23664 ? 437  PRO A C   1 
ATOM   3530 O O   A PRO A 1 356 ? 4.09386   -14.24662 -31.69256 0.789 12.02033 ? 437  PRO A O   1 
ATOM   3531 O O   B PRO A 1 356 ? 3.97940   -13.67479 -31.60465 0.211 12.45783 ? 437  PRO A O   1 
ATOM   3532 C CB  A PRO A 1 356 ? 5.75902   -16.20497 -33.71357 0.789 18.58775 ? 437  PRO A CB  1 
ATOM   3533 C CB  B PRO A 1 356 ? 5.93888   -15.75275 -33.10978 0.211 15.24998 ? 437  PRO A CB  1 
ATOM   3534 C CG  A PRO A 1 356 ? 7.01102   -16.43478 -32.96448 0.789 19.56956 ? 437  PRO A CG  1 
ATOM   3535 C CG  B PRO A 1 356 ? 7.36858   -15.66437 -32.67222 0.211 17.39807 ? 437  PRO A CG  1 
ATOM   3536 C CD  A PRO A 1 356 ? 7.58338   -15.15186 -32.48204 0.789 16.45502 ? 437  PRO A CD  1 
ATOM   3537 C CD  B PRO A 1 356 ? 7.48215   -14.36367 -31.96602 0.211 15.20342 ? 437  PRO A CD  1 
ATOM   3538 N N   A PRO A 1 357 ? 2.99800   -14.47059 -33.65105 0.789 15.29872 ? 438  PRO A N   1 
ATOM   3539 N N   B PRO A 1 357 ? 3.05228   -14.34385 -33.54740 0.211 15.28109 ? 438  PRO A N   1 
ATOM   3540 C CA  A PRO A 1 357 ? 1.70927   -14.10854 -33.04837 0.789 14.39675 ? 438  PRO A CA  1 
ATOM   3541 C CA  B PRO A 1 357 ? 1.68990   -14.10435 -33.06289 0.211 14.37592 ? 438  PRO A CA  1 
ATOM   3542 C C   A PRO A 1 357 ? 1.28718   -15.10735 -31.98605 0.789 14.69538 ? 438  PRO A C   1 
ATOM   3543 C C   B PRO A 1 357 ? 1.29375   -15.10130 -31.98648 0.211 14.74119 ? 438  PRO A C   1 
ATOM   3544 O O   A PRO A 1 357 ? 1.68456   -16.27365 -32.00082 0.789 18.06461 ? 438  PRO A O   1 
ATOM   3545 O O   B PRO A 1 357 ? 1.71299   -16.26145 -31.99160 0.211 17.91001 ? 438  PRO A O   1 
ATOM   3546 C CB  A PRO A 1 357 ? 0.73122   -14.12141 -34.23226 0.789 17.44248 ? 438  PRO A CB  1 
ATOM   3547 C CB  B PRO A 1 357 ? 0.83421   -14.29082 -34.32036 0.211 17.07366 ? 438  PRO A CB  1 
ATOM   3548 C CG  A PRO A 1 357 ? 1.56066   -14.26335 -35.46634 0.789 21.07169 ? 438  PRO A CG  1 
ATOM   3549 C CG  B PRO A 1 357 ? 1.62066   -15.23969 -35.15759 0.211 15.35738 ? 438  PRO A CG  1 
ATOM   3550 C CD  A PRO A 1 357 ? 2.86436   -14.86587 -35.06315 0.789 17.18741 ? 438  PRO A CD  1 
ATOM   3551 C CD  B PRO A 1 357 ? 3.06240   -14.87487 -34.92275 0.211 16.87719 ? 438  PRO A CD  1 
ATOM   3552 N N   . LEU A 1 358 ? 0.47471   -14.62809 -31.05191 1.000 15.45607 ? 439  LEU A N   1 
ATOM   3553 C CA  . LEU A 1 358 ? -0.07408  -15.48278 -30.00947 1.000 17.27514 ? 439  LEU A CA  1 
ATOM   3554 C C   . LEU A 1 358 ? -1.33042  -16.18250 -30.51400 1.000 18.46480 ? 439  LEU A C   1 
ATOM   3555 O O   . LEU A 1 358 ? -1.86049  -17.07936 -29.85707 1.000 23.69241 ? 439  LEU A O   1 
ATOM   3556 C CB  . LEU A 1 358 ? -0.40769  -14.66022 -28.77065 1.000 15.05424 ? 439  LEU A CB  1 
ATOM   3557 C CG  . LEU A 1 358 ? 0.80243   -14.19810 -27.96880 1.000 12.08236 ? 439  LEU A CG  1 
ATOM   3558 C CD1 . LEU A 1 358 ? 0.41782   -13.00701 -27.12532 1.000 14.96150 ? 439  LEU A CD1 1 
ATOM   3559 C CD2 . LEU A 1 358 ? 1.33681   -15.32457 -27.09494 1.000 15.76518 ? 439  LEU A CD2 1 
ATOM   3560 O OXT . LEU A 1 358 ? -1.84916  -15.85394 -31.58082 1.000 21.11732 ? 439  LEU A OXT 1 
HETATM 3561 C C1  A GLC B 2 .   ? 22.54508  2.76258   -22.29167 0.747 11.63291 ? 1    GLC B C1  1 
HETATM 3562 C C2  A GLC B 2 .   ? 21.67152  1.52335   -22.32196 0.747 11.31838 ? 1    GLC B C2  1 
HETATM 3563 C C3  A GLC B 2 .   ? 20.62478  1.53417   -21.26523 0.747 9.08537  ? 1    GLC B C3  1 
HETATM 3564 C C4  A GLC B 2 .   ? 21.15780  1.73925   -19.86740 0.747 9.96155  ? 1    GLC B C4  1 
HETATM 3565 C C5  A GLC B 2 .   ? 22.13709  2.92060   -19.84189 0.747 11.64293 ? 1    GLC B C5  1 
HETATM 3566 C C6  A GLC B 2 .   ? 22.85171  2.95974   -18.51747 0.747 12.37866 ? 1    GLC B C6  1 
HETATM 3567 O O1  A GLC B 2 .   ? 21.81874  3.87233   -22.59578 0.747 13.31788 ? 1    GLC B O1  1 
HETATM 3568 O O2  A GLC B 2 .   ? 21.03552  1.42089   -23.60840 0.747 10.16078 ? 1    GLC B O2  1 
HETATM 3569 O O3  A GLC B 2 .   ? 19.93169  0.25995   -21.38906 0.747 9.99122  ? 1    GLC B O3  1 
HETATM 3570 O O4  A GLC B 2 .   ? 20.10495  2.11809   -18.96040 0.747 10.34069 ? 1    GLC B O4  1 
HETATM 3571 O O5  A GLC B 2 .   ? 23.13812  2.88867   -20.92215 0.747 13.23922 ? 1    GLC B O5  1 
HETATM 3572 O O6  A GLC B 2 .   ? 23.28912  4.26980   -18.23687 0.747 14.91180 ? 1    GLC B O6  1 
HETATM 3573 C C2  B BGC B 2 .   ? 21.81008  1.85161   -22.51328 0.253 8.81653  ? 1    BGC B C2  1 
HETATM 3574 C C3  B BGC B 2 .   ? 20.81791  1.80844   -21.41503 0.253 8.83735  ? 1    BGC B C3  1 
HETATM 3575 C C4  B BGC B 2 .   ? 21.45193  2.01854   -20.06618 0.253 8.87482  ? 1    BGC B C4  1 
HETATM 3576 C C5  B BGC B 2 .   ? 22.45408  3.17765   -20.02740 0.253 10.44546 ? 1    BGC B C5  1 
HETATM 3577 C C6  B BGC B 2 .   ? 23.23921  3.09528   -18.75086 0.253 9.04034  ? 1    BGC B C6  1 
HETATM 3578 C C1  B BGC B 2 .   ? 22.57317  3.16018   -22.44436 0.253 12.33496 ? 1    BGC B C1  1 
HETATM 3579 O O1  B BGC B 2 .   ? 23.39865  3.27577   -23.51287 0.253 15.46540 ? 1    BGC B O1  1 
HETATM 3580 O O2  B BGC B 2 .   ? 21.13412  1.75497   -23.77955 0.253 12.29820 ? 1    BGC B O2  1 
HETATM 3581 O O3  B BGC B 2 .   ? 20.13201  0.52193   -21.45775 0.253 10.18133 ? 1    BGC B O3  1 
HETATM 3582 O O4  B BGC B 2 .   ? 20.45635  2.41961   -19.13308 0.253 8.13330  ? 1    BGC B O4  1 
HETATM 3583 O O5  B BGC B 2 .   ? 23.36779  3.20238   -21.17611 0.253 14.16994 ? 1    BGC B O5  1 
HETATM 3584 O O6  B BGC B 2 .   ? 23.38919  4.37942   -18.20464 0.253 14.48766 ? 1    BGC B O6  1 
HETATM 3585 C C2  A BGC B 2 .   ? 18.68667  1.63824   -17.00779 0.507 8.95114  ? 2    BGC B C2  1 
HETATM 3586 C C2  B BGC B 2 .   ? 19.29415  1.89349   -17.11179 0.493 7.66824  ? 2    BGC B C2  1 
HETATM 3587 C C3  A BGC B 2 .   ? 17.95269  0.58923   -16.23711 0.507 7.91355  ? 2    BGC B C3  1 
HETATM 3588 C C3  B BGC B 2 .   ? 18.53079  0.88488   -16.32752 0.493 7.68013  ? 2    BGC B C3  1 
HETATM 3589 C C4  A BGC B 2 .   ? 17.18206  -0.33888  -17.13226 0.507 8.28701  ? 2    BGC B C4  1 
HETATM 3590 C C4  B BGC B 2 .   ? 17.64763  0.04157   -17.19968 0.493 8.09212  ? 2    BGC B C4  1 
HETATM 3591 C C5  A BGC B 2 .   ? 18.10306  -0.93182  -18.19730 0.507 8.39805  ? 2    BGC B C5  1 
HETATM 3592 C C5  B BGC B 2 .   ? 18.47187  -0.60414  -18.32067 0.493 8.87531  ? 2    BGC B C5  1 
HETATM 3593 C C6  A BGC B 2 .   ? 17.36904  -1.84650  -19.13512 0.507 9.34805  ? 2    BGC B C6  1 
HETATM 3594 C C6  B BGC B 2 .   ? 17.63288  -1.42345  -19.26160 0.493 8.07142  ? 2    BGC B C6  1 
HETATM 3595 C C1  A BGC B 2 .   ? 19.51870  1.06885   -18.15934 0.507 9.94459  ? 2    BGC B C1  1 
HETATM 3596 C C1  B BGC B 2 .   ? 19.99738  1.32888   -18.33117 0.493 9.11901  ? 2    BGC B C1  1 
HETATM 3597 O O2  A BGC B 2 .   ? 19.54080  2.38576   -16.11627 0.507 9.22623  ? 2    BGC B O2  1 
HETATM 3598 O O2  B BGC B 2 .   ? 20.27858  2.50378   -16.25790 0.493 8.83420  ? 2    BGC B O2  1 
HETATM 3599 O O3  A BGC B 2 .   ? 17.02088  1.19509   -15.29121 0.507 9.17611  ? 2    BGC B O3  1 
HETATM 3600 O O3  B BGC B 2 .   ? 17.72226  1.60216   -15.35554 0.493 9.06169  ? 2    BGC B O3  1 
HETATM 3601 O O4  A BGC B 2 .   ? 16.57659  -1.38008  -16.35973 0.507 8.38868  ? 2    BGC B O4  1 
HETATM 3602 O O4  B BGC B 2 .   ? 17.02957  -0.97057  -16.40428 0.493 9.78994  ? 2    BGC B O4  1 
HETATM 3603 O O5  A BGC B 2 .   ? 18.66803  0.16690   -18.98343 0.507 7.47596  ? 2    BGC B O5  1 
HETATM 3604 O O5  B BGC B 2 .   ? 19.11174  0.43519   -19.12494 0.493 8.21895  ? 2    BGC B O5  1 
HETATM 3605 O O6  A BGC B 2 .   ? 18.20288  -2.18529  -20.21755 0.507 8.82146  ? 2    BGC B O6  1 
HETATM 3606 O O6  B BGC B 2 .   ? 18.44367  -1.98301  -20.27052 0.493 8.68969  ? 2    BGC B O6  1 
HETATM 3607 C C2  . BGC C 3 .   ? 31.07665  4.39735   -38.04922 0.593 12.36338 ? 1    BGC C C2  1 
HETATM 3608 C C3  . BGC C 3 .   ? 32.42690  3.77482   -38.08357 0.593 11.64072 ? 1    BGC C C3  1 
HETATM 3609 C C4  . BGC C 3 .   ? 32.56100  2.52886   -37.25006 0.593 11.29829 ? 1    BGC C C4  1 
HETATM 3610 C C5  . BGC C 3 .   ? 31.38722  1.56729   -37.48801 0.593 11.53020 ? 1    BGC C C5  1 
HETATM 3611 C C6  . BGC C 3 .   ? 31.38985  0.39611   -36.54982 0.593 11.63971 ? 1    BGC C C6  1 
HETATM 3612 C C1  . BGC C 3 .   ? 29.97558  3.37762   -38.27545 0.593 10.63190 ? 1    BGC C C1  1 
HETATM 3613 O O1  . BGC C 3 .   ? 28.76337  3.95952   -38.09002 0.593 14.35469 ? 1    BGC C O1  1 
HETATM 3614 O O2  . BGC C 3 .   ? 30.99692  5.38621   -39.09255 0.593 12.32057 ? 1    BGC C O2  1 
HETATM 3615 O O3  . BGC C 3 .   ? 33.39288  4.76123   -37.62589 0.593 12.34311 ? 1    BGC C O3  1 
HETATM 3616 O O4  . BGC C 3 .   ? 33.76343  1.88110   -37.66888 0.593 11.90590 ? 1    BGC C O4  1 
HETATM 3617 O O5  . BGC C 3 .   ? 30.10113  2.24164   -37.31404 0.593 12.51787 ? 1    BGC C O5  1 
HETATM 3618 O O6  . BGC C 3 .   ? 30.23001  -0.36142  -36.76143 0.593 12.13453 ? 1    BGC C O6  1 
HETATM 3619 C C2  . BGC C 3 .   ? 35.79231  0.75620   -37.06759 0.598 11.70513 ? 2    BGC C C2  1 
HETATM 3620 C C3  . BGC C 3 .   ? 36.74658  0.45200   -35.97312 0.598 11.69282 ? 2    BGC C C3  1 
HETATM 3621 C C4  . BGC C 3 .   ? 37.18577  1.68848   -35.23851 0.598 10.82198 ? 2    BGC C C4  1 
HETATM 3622 C C5  . BGC C 3 .   ? 36.00406  2.55586   -34.79002 0.598 11.08406 ? 2    BGC C C5  1 
HETATM 3623 C C6  . BGC C 3 .   ? 36.50100  3.86124   -34.24997 0.598 9.69229  ? 2    BGC C C6  1 
HETATM 3624 C C1  . BGC C 3 .   ? 34.62999  1.59412   -36.56382 0.598 11.21240 ? 2    BGC C C1  1 
HETATM 3625 O O2  . BGC C 3 .   ? 35.25916  -0.46671  -37.61333 0.598 13.18265 ? 2    BGC C O2  1 
HETATM 3626 O O3  . BGC C 3 .   ? 37.91273  -0.20890  -36.53995 0.598 13.19181 ? 2    BGC C O3  1 
HETATM 3627 O O4  . BGC C 3 .   ? 37.91275  1.31714   -34.06864 0.598 12.25540 ? 2    BGC C O4  1 
HETATM 3628 O O5  . BGC C 3 .   ? 35.09639  2.84862   -35.90211 0.598 12.47976 ? 2    BGC C O5  1 
HETATM 3629 O O6  . BGC C 3 .   ? 35.43846  4.58727   -33.69306 0.598 10.24634 ? 2    BGC C O6  1 
HETATM 3630 C C2  . BGC D 4 .   ? 10.70110  -3.10086  -11.17270 1.000 7.88701  ? 501  BGC A C2  1 
HETATM 3631 C C3  . BGC D 4 .   ? 10.44376  -4.28055  -10.30532 1.000 8.38000  ? 501  BGC A C3  1 
HETATM 3632 C C4  . BGC D 4 .   ? 9.82777   -5.43582  -11.05318 1.000 8.06398  ? 501  BGC A C4  1 
HETATM 3633 C C5  . BGC D 4 .   ? 10.57504  -5.74879  -12.35538 1.000 9.14432  ? 501  BGC A C5  1 
HETATM 3634 C C6  . BGC D 4 .   ? 9.84037   -6.71760  -13.22831 1.000 7.83192  ? 501  BGC A C6  1 
HETATM 3635 C C1  . BGC D 4 .   ? 11.48692  -3.50314  -12.39923 1.000 10.06186 ? 501  BGC A C1  1 
HETATM 3636 O O1  . BGC D 4 .   ? 11.65232  -2.45548  -13.24123 1.000 11.79009 ? 501  BGC A O1  1 
HETATM 3637 O O2  . BGC D 4 .   ? 11.46771  -2.12328  -10.44998 1.000 8.90561  ? 501  BGC A O2  1 
HETATM 3638 O O3  . BGC D 4 .   ? 9.58778   -3.85348  -9.20994  1.000 9.30885  ? 501  BGC A O3  1 
HETATM 3639 O O4  . BGC D 4 .   ? 9.89041   -6.59440  -10.21995 1.000 8.72095  ? 501  BGC A O4  1 
HETATM 3640 O O5  . BGC D 4 .   ? 10.74149  -4.54146  -13.14551 1.000 8.49898  ? 501  BGC A O5  1 
HETATM 3641 O O6  . BGC D 4 .   ? 8.70482   -6.09403  -13.77658 1.000 7.88904  ? 501  BGC A O6  1 
HETATM 3642 O O   A HOH E 5 .   ? 3.68148   -31.31063 -15.43384 0.623 27.05685 ? 601  HOH A O   1 
HETATM 3643 O O   B HOH E 5 .   ? 0.76253   -31.16314 -15.09213 0.377 16.00964 ? 601  HOH A O   1 
HETATM 3644 O O   . HOH E 5 .   ? 18.71579  6.16137   2.98355   1.000 26.93887 ? 602  HOH A O   1 
HETATM 3645 O O   . HOH E 5 .   ? 15.30962  -4.23281  -40.23133 1.000 16.96430 ? 603  HOH A O   1 
HETATM 3646 O O   . HOH E 5 .   ? 17.76256  7.95101   -24.18704 1.000 13.98562 ? 604  HOH A O   1 
HETATM 3647 O O   . HOH E 5 .   ? 18.45254  3.47460   -5.12276  1.000 17.03854 ? 605  HOH A O   1 
HETATM 3648 O O   . HOH E 5 .   ? 11.10493  -3.74129  -20.12676 1.000 10.81060 ? 606  HOH A O   1 
HETATM 3649 O O   . HOH E 5 .   ? 16.643    7.118     7.427     1.000 20.01472 ? 607  HOH A O   1 
HETATM 3650 O O   . HOH E 5 .   ? 14.33808  -31.21985 -21.78823 1.000 17.59433 ? 608  HOH A O   1 
HETATM 3651 O O   . HOH E 5 .   ? 27.62875  -1.01290  2.74567   1.000 15.09785 ? 609  HOH A O   1 
HETATM 3652 O O   A HOH E 5 .   ? 7.561     18.052    -12.806   0.510 19.56107 ? 610  HOH A O   1 
HETATM 3653 O O   B HOH E 5 .   ? 6.424     17.955    -8.490    0.490 22.63926 ? 610  HOH A O   1 
HETATM 3654 O O   . HOH E 5 .   ? 3.29382   -11.41637 -35.74190 1.000 22.25179 ? 611  HOH A O   1 
HETATM 3655 O O   . HOH E 5 .   ? 14.21930  9.56004   -27.63744 1.000 13.96023 ? 612  HOH A O   1 
HETATM 3656 O O   . HOH E 5 .   ? 5.25499   -26.89531 -14.78906 1.000 13.25056 ? 613  HOH A O   1 
HETATM 3657 O O   . HOH E 5 .   ? 11.54537  -31.90391 -1.37797  1.000 29.33429 ? 614  HOH A O   1 
HETATM 3658 O O   . HOH E 5 .   ? 13.37084  11.63187  -9.71612  1.000 25.48594 ? 615  HOH A O   1 
HETATM 3659 O O   A HOH E 5 .   ? 3.46614   -32.12677 -17.42727 0.704 22.04460 ? 616  HOH A O   1 
HETATM 3660 O O   B HOH E 5 .   ? 4.40541   -30.79421 -15.15923 0.296 13.26663 ? 616  HOH A O   1 
HETATM 3661 O O   . HOH E 5 .   ? 34.514    9.590     -11.567   1.000 20.83232 ? 617  HOH A O   1 
HETATM 3662 O O   . HOH E 5 .   ? 20.37518  -4.74380  -9.44475  1.000 8.22877  ? 618  HOH A O   1 
HETATM 3663 O O   A HOH E 5 .   ? 30.08586  -24.27523 -20.54003 0.580 12.96221 ? 619  HOH A O   1 
HETATM 3664 O O   B HOH E 5 .   ? 27.56232  -24.13423 -19.70084 0.420 11.29248 ? 619  HOH A O   1 
HETATM 3665 O O   . HOH E 5 .   ? 32.74450  3.36903   -15.68074 1.000 15.25985 ? 620  HOH A O   1 
HETATM 3666 O O   . HOH E 5 .   ? 0.48585   -10.31349 -33.33895 1.000 18.07897 ? 621  HOH A O   1 
HETATM 3667 O O   . HOH E 5 .   ? 16.387    14.206    -16.530   1.000 16.83607 ? 622  HOH A O   1 
HETATM 3668 O O   . HOH E 5 .   ? 17.80439  -23.03382 6.68453   1.000 22.90891 ? 623  HOH A O   1 
HETATM 3669 O O   . HOH E 5 .   ? 17.42713  3.38387   -2.12613  1.000 25.25903 ? 624  HOH A O   1 
HETATM 3670 O O   . HOH E 5 .   ? 31.23017  -8.20337  -34.11117 1.000 27.19553 ? 625  HOH A O   1 
HETATM 3671 O O   . HOH E 5 .   ? 2.91253   0.11976   -26.38500 1.000 12.90552 ? 626  HOH A O   1 
HETATM 3672 O O   . HOH E 5 .   ? -6.09846  -0.97122  -21.95357 1.000 18.92006 ? 627  HOH A O   1 
HETATM 3673 O O   . HOH E 5 .   ? 9.03127   -32.75390 -7.27010  1.000 11.60951 ? 628  HOH A O   1 
HETATM 3674 O O   . HOH E 5 .   ? 17.20083  -28.47418 -23.61040 1.000 27.35979 ? 629  HOH A O   1 
HETATM 3675 O O   . HOH E 5 .   ? 10.88169  15.14868  -18.88897 1.000 23.11789 ? 630  HOH A O   1 
HETATM 3676 O O   A HOH E 5 .   ? 5.44028   13.29953  -17.65105 0.652 18.20796 ? 631  HOH A O   1 
HETATM 3677 O O   B HOH E 5 .   ? 6.07069   13.90881  -16.79951 0.348 15.36300 ? 631  HOH A O   1 
HETATM 3678 O O   . HOH E 5 .   ? -7.14914  -3.58592  -22.04630 1.000 19.92977 ? 632  HOH A O   1 
HETATM 3679 O O   A HOH E 5 .   ? -1.834    8.110     -23.815   0.652 16.13005 ? 633  HOH A O   1 
HETATM 3680 O O   B HOH E 5 .   ? -0.529    7.842     -25.033   0.348 19.29602 ? 633  HOH A O   1 
HETATM 3681 O O   . HOH E 5 .   ? 5.28155   10.81808  -29.05585 1.000 24.34126 ? 634  HOH A O   1 
HETATM 3682 O O   . HOH E 5 .   ? 13.36275  7.11705   -5.02513  1.000 27.24448 ? 635  HOH A O   1 
HETATM 3683 O O   . HOH E 5 .   ? -4.123    -17.704   -30.934   1.000 28.01049 ? 636  HOH A O   1 
HETATM 3684 O O   A HOH E 5 .   ? -4.99496  -6.98117  -32.38991 0.639 21.51423 ? 637  HOH A O   1 
HETATM 3685 O O   B HOH E 5 .   ? -3.35663  -8.67704  -33.21233 0.361 19.55898 ? 637  HOH A O   1 
HETATM 3686 O O   . HOH E 5 .   ? 6.557     -19.254   1.715     1.000 11.19577 ? 638  HOH A O   1 
HETATM 3687 O O   . HOH E 5 .   ? 21.156    9.714     -30.150   1.000 17.52732 ? 639  HOH A O   1 
HETATM 3688 O O   A HOH E 5 .   ? 18.25572  7.69427   -16.22247 0.762 22.38936 ? 640  HOH A O   1 
HETATM 3689 O O   B HOH E 5 .   ? 17.78074  8.40110   -17.07765 0.238 16.52888 ? 640  HOH A O   1 
HETATM 3690 O O   . HOH E 5 .   ? 29.667    -9.820    2.225     1.000 12.91451 ? 641  HOH A O   1 
HETATM 3691 O O   . HOH E 5 .   ? 21.43860  -31.02670 -15.02391 1.000 11.03326 ? 642  HOH A O   1 
HETATM 3692 O O   . HOH E 5 .   ? 14.60430  1.92073   -33.90733 1.000 10.73946 ? 643  HOH A O   1 
HETATM 3693 O O   . HOH E 5 .   ? 3.65468   -33.38582 -2.68032  1.000 27.50380 ? 644  HOH A O   1 
HETATM 3694 O O   . HOH E 5 .   ? 16.47602  -2.99173  -31.31660 1.000 11.72204 ? 645  HOH A O   1 
HETATM 3695 O O   . HOH E 5 .   ? 27.00755  -18.21405 -31.59332 1.000 17.15111 ? 646  HOH A O   1 
HETATM 3696 O O   . HOH E 5 .   ? 14.04711  -33.27211 -8.84429  1.000 17.38717 ? 647  HOH A O   1 
HETATM 3697 O O   . HOH E 5 .   ? -8.64048  -9.68984  -32.71529 1.000 26.51592 ? 648  HOH A O   1 
HETATM 3698 O O   . HOH E 5 .   ? 24.01123  0.82418   8.57726   1.000 16.97110 ? 649  HOH A O   1 
HETATM 3699 O O   . HOH E 5 .   ? 2.58052   -18.28224 -33.41577 1.000 26.52368 ? 650  HOH A O   1 
HETATM 3700 O O   A HOH E 5 .   ? 13.29111  1.05547   -13.97937 0.537 10.34980 ? 651  HOH A O   1 
HETATM 3701 O O   B HOH E 5 .   ? 13.19740  0.37990   -14.46974 0.463 9.42136  ? 651  HOH A O   1 
HETATM 3702 O O   . HOH E 5 .   ? 40.87384  -11.43721 -12.41552 1.000 24.79003 ? 652  HOH A O   1 
HETATM 3703 O O   . HOH E 5 .   ? 18.15755  -7.24855  -44.79087 1.000 26.33239 ? 653  HOH A O   1 
HETATM 3704 O O   A HOH E 5 .   ? 15.29844  2.11735   -14.21994 0.516 9.98839  ? 654  HOH A O   1 
HETATM 3705 O O   B HOH E 5 .   ? 15.12329  2.97653   -13.92860 0.484 9.25598  ? 654  HOH A O   1 
HETATM 3706 O O   . HOH E 5 .   ? 4.30775   8.88821   -26.22113 1.000 21.27664 ? 655  HOH A O   1 
HETATM 3707 O O   . HOH E 5 .   ? 20.44558  -13.52894 8.22842   1.000 19.03806 ? 656  HOH A O   1 
HETATM 3708 O O   . HOH E 5 .   ? 27.59957  5.90814   -32.00037 1.000 13.52587 ? 657  HOH A O   1 
HETATM 3709 O O   . HOH E 5 .   ? 0.30568   0.82287   -26.82738 1.000 26.99187 ? 658  HOH A O   1 
HETATM 3710 O O   . HOH E 5 .   ? 6.37289   -13.18001 -6.27403  1.000 9.41307  ? 659  HOH A O   1 
HETATM 3711 O O   . HOH E 5 .   ? 24.60304  -7.76386  -12.85694 1.000 10.78130 ? 660  HOH A O   1 
HETATM 3712 O O   . HOH E 5 .   ? 34.14070  -8.66650  -6.74257  1.000 20.58677 ? 661  HOH A O   1 
HETATM 3713 O O   . HOH E 5 .   ? 3.26991   -10.74240 -3.94035  1.000 11.85364 ? 662  HOH A O   1 
HETATM 3714 O O   . HOH E 5 .   ? 20.812    5.458     -30.934   1.000 9.27495  ? 663  HOH A O   1 
HETATM 3715 O O   . HOH E 5 .   ? 3.69300   -6.58262  -10.29711 1.000 13.41382 ? 664  HOH A O   1 
HETATM 3716 O O   . HOH E 5 .   ? 22.50094  -29.87119 -10.20614 1.000 10.81518 ? 665  HOH A O   1 
HETATM 3717 O O   A HOH E 5 .   ? 5.62734   -1.34413  -19.83932 0.469 9.18066  ? 666  HOH A O   1 
HETATM 3718 O O   B HOH E 5 .   ? 6.51351   -1.50573  -20.32713 0.531 12.61930 ? 666  HOH A O   1 
HETATM 3719 O O   . HOH E 5 .   ? 14.70279  -14.12805 -31.16755 1.000 14.77044 ? 667  HOH A O   1 
HETATM 3720 O O   . HOH E 5 .   ? 20.33383  -8.00307  -19.25511 1.000 8.70874  ? 668  HOH A O   1 
HETATM 3721 O O   . HOH E 5 .   ? 22.93163  -11.08114 -36.66835 1.000 21.60206 ? 669  HOH A O   1 
HETATM 3722 O O   . HOH E 5 .   ? 19.16312  -4.63738  -19.95160 1.000 9.17550  ? 670  HOH A O   1 
HETATM 3723 O O   . HOH E 5 .   ? 13.10623  -26.89303 -18.93610 1.000 11.88319 ? 671  HOH A O   1 
HETATM 3724 O O   . HOH E 5 .   ? 39.24406  -17.39415 -27.96086 1.000 19.90559 ? 672  HOH A O   1 
HETATM 3725 O O   . HOH E 5 .   ? 25.45683  5.09985   -3.45792  1.000 12.41393 ? 673  HOH A O   1 
HETATM 3726 O O   . HOH E 5 .   ? 10.46694  -30.98027 -8.95626  1.000 10.74607 ? 674  HOH A O   1 
HETATM 3727 O O   . HOH E 5 .   ? 18.13188  -1.47687  -11.92037 1.000 11.21223 ? 675  HOH A O   1 
HETATM 3728 O O   . HOH E 5 .   ? 29.763    -24.197   -5.627    1.000 16.74443 ? 676  HOH A O   1 
HETATM 3729 O O   . HOH E 5 .   ? 29.28274  -22.28768 -17.66135 1.000 14.65875 ? 677  HOH A O   1 
HETATM 3730 O O   . HOH E 5 .   ? -11.411   -16.637   -28.967   1.000 25.36170 ? 678  HOH A O   1 
HETATM 3731 O O   . HOH E 5 .   ? 18.692    -3.595    9.622     1.000 14.20645 ? 679  HOH A O   1 
HETATM 3732 O O   A HOH E 5 .   ? 6.68033   -5.72827  -2.87147  0.456 11.30988 ? 680  HOH A O   1 
HETATM 3733 O O   B HOH E 5 .   ? 7.21459   -4.38605  -0.68905  0.544 13.37441 ? 680  HOH A O   1 
HETATM 3734 O O   A HOH E 5 .   ? 23.86795  4.85572   8.67234   0.807 12.54683 ? 681  HOH A O   1 
HETATM 3735 O O   B HOH E 5 .   ? 24.74613  3.95071   8.52202   0.193 14.96707 ? 681  HOH A O   1 
HETATM 3736 O O   . HOH E 5 .   ? 25.42326  -25.27478 -21.06550 1.000 15.10051 ? 682  HOH A O   1 
HETATM 3737 O O   . HOH E 5 .   ? 15.93778  -13.49661 8.97006   1.000 15.11195 ? 683  HOH A O   1 
HETATM 3738 O O   . HOH E 5 .   ? 32.99163  -16.08428 -30.97034 1.000 15.73297 ? 684  HOH A O   1 
HETATM 3739 O O   . HOH E 5 .   ? -7.892    -0.211    -24.037   1.000 24.69985 ? 685  HOH A O   1 
HETATM 3740 O O   A HOH E 5 .   ? 21.463    -31.100   -22.245   0.551 16.06187 ? 686  HOH A O   1 
HETATM 3741 O O   B HOH E 5 .   ? 20.909    -30.150   -23.222   0.449 13.52315 ? 686  HOH A O   1 
HETATM 3742 O O   . HOH E 5 .   ? 34.79778  -24.49093 -9.08776  1.000 17.69548 ? 687  HOH A O   1 
HETATM 3743 O O   . HOH E 5 .   ? 19.25096  7.05554   -8.65987  1.000 27.30500 ? 688  HOH A O   1 
HETATM 3744 O O   . HOH E 5 .   ? 19.70880  -30.15799 -16.91634 1.000 10.94055 ? 689  HOH A O   1 
HETATM 3745 O O   . HOH E 5 .   ? 34.40441  6.28876   -9.96881  1.000 25.83032 ? 690  HOH A O   1 
HETATM 3746 O O   . HOH E 5 .   ? 10.16764  -1.07071  -8.25604  1.000 12.85473 ? 691  HOH A O   1 
HETATM 3747 O O   A HOH E 5 .   ? 3.54023   -2.75343  -32.72186 0.790 12.41923 ? 692  HOH A O   1 
HETATM 3748 O O   B HOH E 5 .   ? 3.77136   -1.21812  -32.57593 0.210 15.58618 ? 692  HOH A O   1 
HETATM 3749 O O   . HOH E 5 .   ? 37.17679  -4.59076  -25.31761 1.000 9.48253  ? 693  HOH A O   1 
HETATM 3750 O O   . HOH E 5 .   ? 32.733    -24.383   -30.657   1.000 23.54785 ? 694  HOH A O   1 
HETATM 3751 O O   . HOH E 5 .   ? 39.680    -13.387   -5.162    1.000 16.08900 ? 695  HOH A O   1 
HETATM 3752 O O   . HOH E 5 .   ? 11.64403  -16.07987 -33.46536 1.000 20.36697 ? 696  HOH A O   1 
HETATM 3753 O O   A HOH E 5 .   ? 28.14119  -25.36073 -15.11914 0.613 13.57540 ? 697  HOH A O   1 
HETATM 3754 O O   B HOH E 5 .   ? 29.70183  -25.16171 -14.76646 0.387 12.12441 ? 697  HOH A O   1 
HETATM 3755 O O   A HOH E 5 .   ? 29.22319  6.76867   -17.81202 0.667 19.56130 ? 698  HOH A O   1 
HETATM 3756 O O   B HOH E 5 .   ? 30.79219  6.37863   -17.97835 0.333 11.44702 ? 698  HOH A O   1 
HETATM 3757 O O   . HOH E 5 .   ? 15.65640  -25.85828 -4.69631  1.000 15.27471 ? 699  HOH A O   1 
HETATM 3758 O O   . HOH E 5 .   ? 11.73498  -2.84777  -16.11487 1.000 11.74455 ? 700  HOH A O   1 
HETATM 3759 O O   . HOH E 5 .   ? -13.53547 -9.81297  -24.15808 1.000 13.09239 ? 701  HOH A O   1 
HETATM 3760 O O   . HOH E 5 .   ? 29.42617  0.80876   -1.38337  1.000 9.95850  ? 702  HOH A O   1 
HETATM 3761 O O   . HOH E 5 .   ? 6.69102   -2.06816  -7.95836  1.000 21.79642 ? 703  HOH A O   1 
HETATM 3762 O O   . HOH E 5 .   ? 15.60766  2.54383   0.25642   1.000 19.70496 ? 704  HOH A O   1 
HETATM 3763 O O   . HOH E 5 .   ? 20.63188  10.82373  -26.21894 1.000 12.17810 ? 705  HOH A O   1 
HETATM 3764 O O   A HOH E 5 .   ? 32.884    -26.428   -20.541   0.578 20.12703 ? 706  HOH A O   1 
HETATM 3765 O O   B HOH E 5 .   ? 36.800    -22.958   -18.975   0.422 11.09510 ? 706  HOH A O   1 
HETATM 3766 O O   . HOH E 5 .   ? 31.53229  -12.34713 -6.55058  1.000 10.06315 ? 707  HOH A O   1 
HETATM 3767 O O   A HOH E 5 .   ? 7.85545   -31.11348 -1.13983  0.672 15.74552 ? 708  HOH A O   1 
HETATM 3768 O O   B HOH E 5 .   ? 7.13400   -31.68291 -1.47442  0.328 11.45280 ? 708  HOH A O   1 
HETATM 3769 O O   . HOH E 5 .   ? 10.38790  -13.83014 4.15904   1.000 10.71799 ? 709  HOH A O   1 
HETATM 3770 O O   A HOH E 5 .   ? 13.94747  -22.40553 -21.28012 0.585 5.80582  ? 710  HOH A O   1 
HETATM 3771 O O   B HOH E 5 .   ? 13.39679  -21.93626 -21.75976 0.415 13.27662 ? 710  HOH A O   1 
HETATM 3772 O O   A HOH E 5 .   ? 23.128    -29.140   -23.209   0.591 13.54364 ? 711  HOH A O   1 
HETATM 3773 O O   B HOH E 5 .   ? 23.273    -29.724   -22.152   0.409 13.97298 ? 711  HOH A O   1 
HETATM 3774 O O   . HOH E 5 .   ? 26.35793  -15.06324 6.70307   1.000 24.80759 ? 712  HOH A O   1 
HETATM 3775 O O   . HOH E 5 .   ? 24.40970  3.70596   -31.43564 1.000 10.41376 ? 713  HOH A O   1 
HETATM 3776 O O   A HOH E 5 .   ? 9.24262   -5.31687  -29.37019 0.776 8.09212  ? 714  HOH A O   1 
HETATM 3777 O O   B HOH E 5 .   ? 8.89126   -4.96269  -29.25227 0.224 5.31307  ? 714  HOH A O   1 
HETATM 3778 O O   A HOH E 5 .   ? 16.320    -9.423    8.980     0.498 16.69958 ? 715  HOH A O   1 
HETATM 3779 O O   B HOH E 5 .   ? 14.917    -9.913    8.697     0.502 20.79654 ? 715  HOH A O   1 
HETATM 3780 O O   . HOH E 5 .   ? 8.84049   -17.76508 -12.51671 1.000 7.59192  ? 716  HOH A O   1 
HETATM 3781 O O   . HOH E 5 .   ? -0.51391  0.03525   -11.99990 1.000 21.00619 ? 717  HOH A O   1 
HETATM 3782 O O   . HOH E 5 .   ? 7.57255   -8.05038  -10.62377 1.000 8.84111  ? 718  HOH A O   1 
HETATM 3783 O O   . HOH E 5 .   ? 11.49143  -9.21011  -33.57935 1.000 19.46132 ? 719  HOH A O   1 
HETATM 3784 O O   A HOH E 5 .   ? 4.40045   -7.42372  -34.62860 0.717 11.23341 ? 720  HOH A O   1 
HETATM 3785 O O   B HOH E 5 .   ? 3.81726   -6.83431  -34.51193 0.283 9.30893  ? 720  HOH A O   1 
HETATM 3786 O O   . HOH E 5 .   ? 9.06558   -20.49689 -12.16002 1.000 8.91386  ? 721  HOH A O   1 
HETATM 3787 O O   . HOH E 5 .   ? 5.01540   -17.46531 -16.67057 1.000 8.22466  ? 722  HOH A O   1 
HETATM 3788 O O   A HOH E 5 .   ? 8.20367   3.39667   -29.93875 0.575 8.39572  ? 723  HOH A O   1 
HETATM 3789 O O   B HOH E 5 .   ? 7.29790   5.71584   -31.00265 0.238 8.04787  ? 723  HOH A O   1 
HETATM 3790 O O   C HOH E 5 .   ? 7.63551   3.99117   -30.21290 0.187 8.30452  ? 723  HOH A O   1 
HETATM 3791 O O   . HOH E 5 .   ? 10.40352  6.87282   -14.05039 1.000 10.25884 ? 724  HOH A O   1 
HETATM 3792 O O   . HOH E 5 .   ? 37.15222  -22.92066 -7.82974  1.000 14.94503 ? 725  HOH A O   1 
HETATM 3793 O O   A HOH E 5 .   ? 18.14140  -26.06632 -5.52711  0.737 14.66492 ? 726  HOH A O   1 
HETATM 3794 O O   B HOH E 5 .   ? 18.14080  -24.91792 -5.88917  0.263 8.55629  ? 726  HOH A O   1 
HETATM 3795 O O   A HOH E 5 .   ? 30.56416  -21.32685 -23.67237 0.661 17.03344 ? 727  HOH A O   1 
HETATM 3796 O O   B HOH E 5 .   ? 31.47465  -20.70215 -23.24856 0.339 12.26168 ? 727  HOH A O   1 
HETATM 3797 O O   . HOH E 5 .   ? 38.43510  -2.23350  -24.29808 1.000 10.04043 ? 728  HOH A O   1 
HETATM 3798 O O   . HOH E 5 .   ? 12.94256  -17.71065 4.60195   1.000 9.35945  ? 729  HOH A O   1 
HETATM 3799 O O   . HOH E 5 .   ? 25.19550  -0.92954  3.90512   1.000 15.46995 ? 730  HOH A O   1 
HETATM 3800 O O   A HOH E 5 .   ? 22.12471  5.16682   1.81276   0.553 12.66318 ? 731  HOH A O   1 
HETATM 3801 O O   B HOH E 5 .   ? 22.15141  5.26717   0.74341   0.447 15.50474 ? 731  HOH A O   1 
HETATM 3802 O O   . HOH E 5 .   ? 4.34185   -12.79611 0.13549   1.000 15.19426 ? 732  HOH A O   1 
HETATM 3803 O O   . HOH E 5 .   ? 40.73307  -12.96194 -8.00008  1.000 28.39195 ? 733  HOH A O   1 
HETATM 3804 O O   . HOH E 5 .   ? 18.15110  0.88677   -23.80921 1.000 8.98789  ? 734  HOH A O   1 
HETATM 3805 O O   . HOH E 5 .   ? 8.87976   -14.07977 -36.40200 1.000 27.24254 ? 735  HOH A O   1 
HETATM 3806 O O   . HOH E 5 .   ? 22.58740  2.01060   -25.78173 1.000 12.11355 ? 736  HOH A O   1 
HETATM 3807 O O   A HOH E 5 .   ? 16.40909  -4.59677  -36.94178 0.603 7.49797  ? 737  HOH A O   1 
HETATM 3808 O O   B HOH E 5 .   ? 14.90445  -6.81504  -37.50535 0.397 9.74345  ? 737  HOH A O   1 
HETATM 3809 O O   A HOH E 5 .   ? -0.38675  -18.72836 -27.29071 0.727 15.46098 ? 738  HOH A O   1 
HETATM 3810 O O   B HOH E 5 .   ? -1.11974  -18.06748 -27.93909 0.273 17.25957 ? 738  HOH A O   1 
HETATM 3811 O O   . HOH E 5 .   ? -14.48595 -7.17172  -30.96970 1.000 32.32116 ? 739  HOH A O   1 
HETATM 3812 O O   . HOH E 5 .   ? 35.79693  -10.89021 -29.20009 1.000 13.61682 ? 740  HOH A O   1 
HETATM 3813 O O   A HOH E 5 .   ? 41.90530  -17.47596 -11.05778 0.731 16.79678 ? 741  HOH A O   1 
HETATM 3814 O O   B HOH E 5 .   ? 40.43986  -16.66440 -14.23885 0.269 12.87389 ? 741  HOH A O   1 
HETATM 3815 O O   . HOH E 5 .   ? 1.91271   -6.81676  -6.82755  1.000 17.41079 ? 742  HOH A O   1 
HETATM 3816 O O   A HOH E 5 .   ? 40.59103  -20.97243 -13.79155 0.672 12.10481 ? 743  HOH A O   1 
HETATM 3817 O O   B HOH E 5 .   ? 39.83811  -21.26294 -14.86515 0.328 15.48918 ? 743  HOH A O   1 
HETATM 3818 O O   A HOH E 5 .   ? 11.55919  -12.76636 7.32450   0.508 9.45180  ? 744  HOH A O   1 
HETATM 3819 O O   B HOH E 5 .   ? 12.76491  -9.26956  5.83839   0.492 8.69954  ? 744  HOH A O   1 
HETATM 3820 O O   . HOH E 5 .   ? 8.84703   4.09769   -11.32205 1.000 8.37976  ? 745  HOH A O   1 
HETATM 3821 O O   . HOH E 5 .   ? 3.81513   7.66213   -9.20504  1.000 24.35738 ? 746  HOH A O   1 
HETATM 3822 O O   . HOH E 5 .   ? 6.78939   -13.22804 -14.47024 1.000 8.85754  ? 747  HOH A O   1 
HETATM 3823 O O   . HOH E 5 .   ? 19.57876  -21.78076 5.29783   1.000 22.83415 ? 748  HOH A O   1 
HETATM 3824 O O   . HOH E 5 .   ? 6.67113   5.59157   -19.88929 1.000 9.84046  ? 749  HOH A O   1 
HETATM 3825 O O   . HOH E 5 .   ? 20.88436  -4.89087  -17.81088 1.000 10.01864 ? 750  HOH A O   1 
HETATM 3826 O O   A HOH E 5 .   ? -0.82017  -32.75728 -10.61355 0.604 13.24777 ? 751  HOH A O   1 
HETATM 3827 O O   B HOH E 5 .   ? -1.51111  -35.16601 -11.58660 0.396 8.70381  ? 751  HOH A O   1 
HETATM 3828 O O   A HOH E 5 .   ? 24.26611  -0.14990  -37.18357 0.625 10.92592 ? 752  HOH A O   1 
HETATM 3829 O O   B HOH E 5 .   ? 23.39736  -0.00419  -39.78180 0.375 11.33209 ? 752  HOH A O   1 
HETATM 3830 O O   . HOH E 5 .   ? 30.630    -10.603   -0.125    1.000 8.99768  ? 753  HOH A O   1 
HETATM 3831 O O   . HOH E 5 .   ? -6.76427  -18.59615 -24.04654 1.000 16.34330 ? 754  HOH A O   1 
HETATM 3832 O O   . HOH E 5 .   ? 14.825    -35.409   -16.401   1.000 15.71345 ? 755  HOH A O   1 
HETATM 3833 O O   A HOH E 5 .   ? 22.48393  8.46585   -10.10241 0.615 13.47552 ? 756  HOH A O   1 
HETATM 3834 O O   B HOH E 5 .   ? 21.42682  8.24752   -10.45674 0.385 15.48951 ? 756  HOH A O   1 
HETATM 3835 O O   A HOH E 5 .   ? 2.18029   -15.07424 -6.75376  0.554 13.31260 ? 757  HOH A O   1 
HETATM 3836 O O   B HOH E 5 .   ? 2.43114   -15.12090 -5.12907  0.446 12.37173 ? 757  HOH A O   1 
HETATM 3837 O O   . HOH E 5 .   ? 7.13053   -11.01925 -7.86769  1.000 7.70032  ? 758  HOH A O   1 
HETATM 3838 O O   . HOH E 5 .   ? -9.63546  -3.88210  -24.97053 1.000 13.56496 ? 759  HOH A O   1 
HETATM 3839 O O   . HOH E 5 .   ? 17.26628  -5.31745  -34.38054 1.000 10.80256 ? 760  HOH A O   1 
HETATM 3840 O O   . HOH E 5 .   ? 11.35855  13.36122  -8.87441  1.000 28.52514 ? 761  HOH A O   1 
HETATM 3841 O O   A HOH E 5 .   ? 39.112    -9.249    -22.076   0.795 11.63272 ? 762  HOH A O   1 
HETATM 3842 O O   B HOH E 5 .   ? 40.243    -8.653    -21.322   0.205 9.56466  ? 762  HOH A O   1 
HETATM 3843 O O   . HOH E 5 .   ? 28.14094  -27.62562 -18.98029 1.000 23.55873 ? 763  HOH A O   1 
HETATM 3844 O O   . HOH E 5 .   ? 1.45786   7.88232   -14.25989 1.000 18.90178 ? 764  HOH A O   1 
HETATM 3845 O O   A HOH E 5 .   ? 18.45757  -0.94603  3.76255   0.539 7.73147  ? 765  HOH A O   1 
HETATM 3846 O O   B HOH E 5 .   ? 17.67476  0.04317   3.98411   0.461 14.73101 ? 765  HOH A O   1 
HETATM 3847 O O   A HOH E 5 .   ? 24.42659  -19.81328 3.61253   0.644 12.89423 ? 766  HOH A O   1 
HETATM 3848 O O   B HOH E 5 .   ? 23.87853  -20.68514 1.80011   0.356 13.30683 ? 766  HOH A O   1 
HETATM 3849 O O   . HOH E 5 .   ? 29.81112  -21.23812 -2.25568  1.000 10.48355 ? 767  HOH A O   1 
HETATM 3850 O O   . HOH E 5 .   ? 6.858     -7.525    -35.544   1.000 16.92986 ? 768  HOH A O   1 
HETATM 3851 O O   . HOH E 5 .   ? 32.27208  0.39078   -31.82127 1.000 12.22860 ? 769  HOH A O   1 
HETATM 3852 O O   . HOH E 5 .   ? 36.33380  -3.66602  -15.53855 1.000 20.83769 ? 770  HOH A O   1 
HETATM 3853 O O   A HOH E 5 .   ? 33.08530  -5.19815  -1.64409  0.789 11.21458 ? 771  HOH A O   1 
HETATM 3854 O O   B HOH E 5 .   ? 33.32401  -5.24239  -2.47601  0.211 6.94658  ? 771  HOH A O   1 
HETATM 3855 O O   A HOH E 5 .   ? 15.68607  -23.95529 5.62353   0.692 12.74357 ? 772  HOH A O   1 
HETATM 3856 O O   B HOH E 5 .   ? 15.37629  -26.26735 6.45352   0.308 16.99730 ? 772  HOH A O   1 
HETATM 3857 O O   . HOH E 5 .   ? 28.78803  -6.14562  -37.52874 1.000 19.68628 ? 773  HOH A O   1 
HETATM 3858 O O   . HOH E 5 .   ? 23.70012  -12.38923 6.80377   1.000 20.57905 ? 774  HOH A O   1 
HETATM 3859 O O   . HOH E 5 .   ? -12.73990 -3.53081  -20.44821 1.000 16.25251 ? 775  HOH A O   1 
HETATM 3860 O O   . HOH E 5 .   ? 6.36392   -4.06909  -19.62067 1.000 8.99711  ? 776  HOH A O   1 
HETATM 3861 O O   . HOH E 5 .   ? 19.85094  -4.53095  -34.60192 1.000 10.69529 ? 777  HOH A O   1 
HETATM 3862 O O   A HOH E 5 .   ? 20.66844  -0.38308  -40.40632 0.571 11.13760 ? 778  HOH A O   1 
HETATM 3863 O O   B HOH E 5 .   ? 20.05437  2.30801   -40.77314 0.429 10.88224 ? 778  HOH A O   1 
HETATM 3864 O O   . HOH E 5 .   ? 18.66024  -17.14349 -32.78617 1.000 32.50363 ? 779  HOH A O   1 
HETATM 3865 O O   . HOH E 5 .   ? -8.83887  -14.40455 -17.85965 1.000 19.35114 ? 780  HOH A O   1 
HETATM 3866 O O   . HOH E 5 .   ? 17.14901  10.68225  -17.32920 1.000 26.49073 ? 781  HOH A O   1 
HETATM 3867 O O   . HOH E 5 .   ? 9.76571   -38.86879 -15.79826 1.000 20.67932 ? 782  HOH A O   1 
HETATM 3868 O O   . HOH E 5 .   ? -0.16739  -6.55031  -10.51684 1.000 11.80523 ? 783  HOH A O   1 
HETATM 3869 O O   . HOH E 5 .   ? -6.36474  -12.93817 -11.78134 1.000 15.45616 ? 784  HOH A O   1 
HETATM 3870 O O   . HOH E 5 .   ? 22.138    -19.226   -35.573   1.000 26.02133 ? 785  HOH A O   1 
HETATM 3871 O O   . HOH E 5 .   ? 12.99279  -8.56402  -24.78233 1.000 8.30157  ? 786  HOH A O   1 
HETATM 3872 O O   A HOH E 5 .   ? 20.08671  -2.11926  -10.03118 0.518 5.87515  ? 787  HOH A O   1 
HETATM 3873 O O   B HOH E 5 .   ? 22.28611  -0.49237  -10.48824 0.482 6.36978  ? 787  HOH A O   1 
HETATM 3874 O O   A HOH E 5 .   ? 16.47481  -8.32227  4.98375   0.606 11.16207 ? 788  HOH A O   1 
HETATM 3875 O O   B HOH E 5 .   ? 16.34669  -7.19684  5.28505   0.394 19.25041 ? 788  HOH A O   1 
HETATM 3876 O O   . HOH E 5 .   ? 19.59270  5.08891   -1.47422  1.000 23.48518 ? 789  HOH A O   1 
HETATM 3877 O O   . HOH E 5 .   ? 30.74362  -2.40406  1.09487   1.000 14.83779 ? 790  HOH A O   1 
HETATM 3878 O O   . HOH E 5 .   ? 4.10279   -22.47889 -23.51365 1.000 13.79617 ? 791  HOH A O   1 
HETATM 3879 O O   . HOH E 5 .   ? 1.24780   -27.96462 -7.31764  1.000 12.66450 ? 792  HOH A O   1 
HETATM 3880 O O   . HOH E 5 .   ? 38.56117  -18.26803 -7.70303  1.000 13.58427 ? 793  HOH A O   1 
HETATM 3881 O O   A HOH E 5 .   ? 11.218    0.999     -38.387   0.584 10.01957 ? 794  HOH A O   1 
HETATM 3882 O O   B HOH E 5 .   ? 13.574    2.352     -38.687   0.416 8.66967  ? 794  HOH A O   1 
HETATM 3883 O O   . HOH E 5 .   ? 17.36200  0.55660   -3.47231  1.000 11.81631 ? 795  HOH A O   1 
HETATM 3884 O O   . HOH E 5 .   ? -1.15822  5.00410   -21.05675 1.000 15.22543 ? 796  HOH A O   1 
HETATM 3885 O O   . HOH E 5 .   ? 34.93207  -19.92899 -28.72944 1.000 24.66889 ? 797  HOH A O   1 
HETATM 3886 O O   . HOH E 5 .   ? -2.05415  -17.37459 -10.10931 1.000 20.76911 ? 798  HOH A O   1 
HETATM 3887 O O   A HOH E 5 .   ? 25.55938  -18.72690 -33.75130 0.501 19.66563 ? 799  HOH A O   1 
HETATM 3888 O O   B HOH E 5 .   ? 26.32600  -16.51510 -34.70811 0.499 16.21196 ? 799  HOH A O   1 
HETATM 3889 O O   . HOH E 5 .   ? 18.53136  -25.77661 -8.26927  1.000 10.11093 ? 800  HOH A O   1 
HETATM 3890 O O   . HOH E 5 .   ? -8.78252  -12.65663 -12.85568 1.000 21.65505 ? 801  HOH A O   1 
HETATM 3891 O O   . HOH E 5 .   ? 19.66810  5.75214   -21.38131 1.000 17.79915 ? 802  HOH A O   1 
HETATM 3892 O O   . HOH E 5 .   ? 13.70435  -1.20628  -19.22330 1.000 12.50632 ? 803  HOH A O   1 
HETATM 3893 O O   A HOH E 5 .   ? 24.22857  -5.81532  -15.00520 0.676 8.40225  ? 804  HOH A O   1 
HETATM 3894 O O   B HOH E 5 .   ? 24.04872  -5.66437  -14.16463 0.324 7.76748  ? 804  HOH A O   1 
HETATM 3895 O O   . HOH E 5 .   ? 7.48884   -19.52495 -15.45857 1.000 9.43060  ? 805  HOH A O   1 
HETATM 3896 O O   . HOH E 5 .   ? 25.13069  -23.78021 -24.39922 1.000 17.32971 ? 806  HOH A O   1 
HETATM 3897 O O   . HOH E 5 .   ? 2.76834   6.82988   -11.27919 1.000 22.83970 ? 807  HOH A O   1 
HETATM 3898 O O   . HOH E 5 .   ? -0.864    -24.185   -17.900   1.000 24.08368 ? 808  HOH A O   1 
HETATM 3899 O O   . HOH E 5 .   ? 1.98380   -22.36336 -11.88592 1.000 14.13683 ? 809  HOH A O   1 
HETATM 3900 O O   . HOH E 5 .   ? 15.78352  -27.41498 -27.84318 1.000 27.26367 ? 810  HOH A O   1 
HETATM 3901 O O   . HOH E 5 .   ? 12.71341  -2.99752  -3.12413  1.000 11.53086 ? 811  HOH A O   1 
HETATM 3902 O O   . HOH E 5 .   ? -14.37500 -10.54848 -19.66551 1.000 13.13280 ? 812  HOH A O   1 
HETATM 3903 O O   . HOH E 5 .   ? 30.39676  -10.71663 -32.73609 1.000 15.78989 ? 813  HOH A O   1 
HETATM 3904 O O   . HOH E 5 .   ? 34.06540  3.70562   -6.06107  1.000 24.40641 ? 814  HOH A O   1 
HETATM 3905 O O   . HOH E 5 .   ? 10.63999  -20.21631 -29.55578 1.000 13.44943 ? 815  HOH A O   1 
HETATM 3906 O O   A HOH E 5 .   ? -3.528    -0.574    -25.606   0.371 15.79472 ? 816  HOH A O   1 
HETATM 3907 O O   B HOH E 5 .   ? -3.552    -1.313    -26.078   0.629 12.25152 ? 816  HOH A O   1 
HETATM 3908 O O   . HOH E 5 .   ? 20.77820  5.01030   -16.94433 1.000 11.77270 ? 817  HOH A O   1 
HETATM 3909 O O   A HOH E 5 .   ? 25.56077  1.12759   6.48733   0.805 13.41902 ? 818  HOH A O   1 
HETATM 3910 O O   B HOH E 5 .   ? 25.00810  -0.04914  6.70950   0.195 14.56451 ? 818  HOH A O   1 
HETATM 3911 O O   . HOH E 5 .   ? 8.94176   -11.47519 3.82638   1.000 9.56192  ? 819  HOH A O   1 
HETATM 3912 O O   . HOH E 5 .   ? 9.00774   -5.72690  1.09259   1.000 11.69993 ? 820  HOH A O   1 
HETATM 3913 O O   . HOH E 5 .   ? 1.804     -17.148   -2.991    1.000 13.91499 ? 821  HOH A O   1 
HETATM 3914 O O   A HOH E 5 .   ? -0.72863  -11.89508 -31.19621 0.751 14.47644 ? 822  HOH A O   1 
HETATM 3915 O O   B HOH E 5 .   ? -2.25592  -11.43311 -30.49541 0.249 9.63240  ? 822  HOH A O   1 
HETATM 3916 O O   . HOH E 5 .   ? 20.14309  -7.10301  8.46412   1.000 21.20029 ? 823  HOH A O   1 
HETATM 3917 O O   . HOH E 5 .   ? 20.01856  -19.21134 4.89545   1.000 13.24663 ? 824  HOH A O   1 
HETATM 3918 O O   . HOH E 5 .   ? -2.89330  -0.93705  -15.39332 1.000 13.80328 ? 825  HOH A O   1 
HETATM 3919 O O   . HOH E 5 .   ? 21.30695  -28.23621 -8.24043  1.000 10.01000 ? 826  HOH A O   1 
HETATM 3920 O O   . HOH E 5 .   ? 18.61336  -28.78263 0.54817   1.000 23.03295 ? 827  HOH A O   1 
HETATM 3921 O O   A HOH E 5 .   ? 6.87186   -5.15323  -5.46585  0.594 16.15716 ? 828  HOH A O   1 
HETATM 3922 O O   B HOH E 5 .   ? 7.76073   -5.61451  -4.59339  0.406 11.20093 ? 828  HOH A O   1 
HETATM 3923 O O   . HOH E 5 .   ? 40.34630  -12.91174 -21.09406 1.000 14.43125 ? 829  HOH A O   1 
HETATM 3924 O O   . HOH E 5 .   ? 11.93329  -31.08166 -20.35536 1.000 24.56665 ? 830  HOH A O   1 
HETATM 3925 O O   . HOH E 5 .   ? 19.435    6.837     -32.902   1.000 12.76630 ? 831  HOH A O   1 
HETATM 3926 O O   . HOH E 5 .   ? 12.55413  -20.15167 -19.98007 1.000 9.22608  ? 832  HOH A O   1 
HETATM 3927 O O   A HOH E 5 .   ? 15.51742  5.39693   -34.99784 0.479 11.67148 ? 833  HOH A O   1 
HETATM 3928 O O   B HOH E 5 .   ? 18.31511  5.76370   -35.33603 0.521 11.62045 ? 833  HOH A O   1 
HETATM 3929 O O   . HOH E 5 .   ? 10.78833  -9.54118  -21.52749 1.000 10.38965 ? 834  HOH A O   1 
HETATM 3930 O O   A HOH E 5 .   ? 23.22600  -9.89401  7.26774   0.515 14.40212 ? 835  HOH A O   1 
HETATM 3931 O O   B HOH E 5 .   ? 25.19131  -7.65811  1.14382   0.485 10.27687 ? 835  HOH A O   1 
HETATM 3932 O O   . HOH E 5 .   ? -3.52462  -7.43923  -14.09340 1.000 14.65516 ? 836  HOH A O   1 
HETATM 3933 O O   . HOH E 5 .   ? 20.69808  2.07943   -13.50499 1.000 10.65595 ? 837  HOH A O   1 
HETATM 3934 O O   . HOH E 5 .   ? 15.50006  -13.31779 -35.52794 1.000 25.49194 ? 838  HOH A O   1 
HETATM 3935 O O   . HOH E 5 .   ? 25.86086  -26.91409 -3.66018  1.000 15.96296 ? 839  HOH A O   1 
HETATM 3936 O O   . HOH E 5 .   ? 14.44877  -2.27890  -13.45258 1.000 15.11579 ? 840  HOH A O   1 
HETATM 3937 O O   . HOH E 5 .   ? -0.94317  4.47946   -16.82494 1.000 15.64201 ? 841  HOH A O   1 
HETATM 3938 O O   . HOH E 5 .   ? 9.44336   -34.93837 -8.82000  1.000 24.04008 ? 842  HOH A O   1 
HETATM 3939 O O   A HOH E 5 .   ? 28.96756  -23.75351 -24.76922 0.648 25.35620 ? 843  HOH A O   1 
HETATM 3940 O O   B HOH E 5 .   ? 30.07789  -22.61663 -25.22874 0.352 19.58621 ? 843  HOH A O   1 
HETATM 3941 O O   . HOH E 5 .   ? 11.39763  -17.73578 -19.56648 1.000 7.38191  ? 844  HOH A O   1 
HETATM 3942 O O   A HOH E 5 .   ? 16.33576  9.55012   -33.34012 0.567 13.97241 ? 845  HOH A O   1 
HETATM 3943 O O   B HOH E 5 .   ? 16.77609  8.67619   -34.47248 0.433 17.38655 ? 845  HOH A O   1 
HETATM 3944 O O   A HOH E 5 .   ? 3.95249   -24.03845 -20.22972 0.771 13.20979 ? 846  HOH A O   1 
HETATM 3945 O O   B HOH E 5 .   ? 2.40280   -24.06664 -20.24004 0.229 12.21529 ? 846  HOH A O   1 
HETATM 3946 O O   A HOH E 5 .   ? 2.45163   -21.54790 -6.27590  0.532 12.56376 ? 847  HOH A O   1 
HETATM 3947 O O   B HOH E 5 .   ? 0.38195   -22.25083 -7.73478  0.468 15.18593 ? 847  HOH A O   1 
HETATM 3948 O O   A HOH E 5 .   ? -3.758    -21.088   -23.658   0.554 17.92201 ? 848  HOH A O   1 
HETATM 3949 O O   B HOH E 5 .   ? -5.122    -21.593   -23.922   0.446 15.67951 ? 848  HOH A O   1 
HETATM 3950 O O   . HOH E 5 .   ? 31.34299  -21.56774 -13.45230 1.000 11.61419 ? 849  HOH A O   1 
HETATM 3951 O O   . HOH E 5 .   ? 16.11620  -6.92956  -39.97577 1.000 15.75406 ? 850  HOH A O   1 
HETATM 3952 O O   . HOH E 5 .   ? -16.51655 -6.96766  -26.74700 1.000 15.08311 ? 851  HOH A O   1 
HETATM 3953 O O   . HOH E 5 .   ? 22.34312  -18.22374 3.45490   1.000 15.94013 ? 852  HOH A O   1 
HETATM 3954 O O   . HOH E 5 .   ? 16.56444  -2.29297  -2.63512  1.000 8.21902  ? 853  HOH A O   1 
HETATM 3955 O O   A HOH E 5 .   ? 26.47825  -1.63332  -36.87342 0.437 11.93064 ? 854  HOH A O   1 
HETATM 3956 O O   B HOH E 5 .   ? 25.39014  -1.20948  -36.22835 0.563 12.14149 ? 854  HOH A O   1 
HETATM 3957 O O   . HOH E 5 .   ? 5.74959   -11.44152 -12.64030 1.000 8.01904  ? 855  HOH A O   1 
HETATM 3958 O O   . HOH E 5 .   ? 28.71109  4.40836   0.25017   1.000 23.03208 ? 856  HOH A O   1 
HETATM 3959 O O   . HOH E 5 .   ? 10.57048  -12.00753 -32.74689 1.000 15.67113 ? 857  HOH A O   1 
HETATM 3960 O O   . HOH E 5 .   ? 17.38556  -4.83593  -16.65099 1.000 11.13816 ? 858  HOH A O   1 
HETATM 3961 O O   . HOH E 5 .   ? 27.35890  -27.48604 -13.95208 1.000 15.95542 ? 859  HOH A O   1 
HETATM 3962 O O   A HOH E 5 .   ? 11.07264  -33.87312 -15.87119 0.742 13.95833 ? 860  HOH A O   1 
HETATM 3963 O O   B HOH E 5 .   ? 10.24947  -32.98080 -16.15231 0.258 18.09007 ? 860  HOH A O   1 
HETATM 3964 O O   A HOH E 5 .   ? 2.09063   -34.02763 -5.08380  0.541 15.79761 ? 861  HOH A O   1 
HETATM 3965 O O   B HOH E 5 .   ? 0.32464   -32.71627 -6.34813  0.459 14.64529 ? 861  HOH A O   1 
HETATM 3966 O O   . HOH E 5 .   ? 8.29323   -21.44491 -24.07497 1.000 15.66877 ? 862  HOH A O   1 
HETATM 3967 O O   A HOH E 5 .   ? 31.20807  -9.62163  -6.68167  0.518 10.75283 ? 863  HOH A O   1 
HETATM 3968 O O   B HOH E 5 .   ? 32.48832  -9.79141  -6.08093  0.482 16.12313 ? 863  HOH A O   1 
HETATM 3969 O O   . HOH E 5 .   ? 27.63599  0.76051   -37.16981 1.000 16.79735 ? 864  HOH A O   1 
HETATM 3970 O O   A HOH E 5 .   ? 7.57519   -21.85654 2.40524   0.751 10.27738 ? 865  HOH A O   1 
HETATM 3971 O O   B HOH E 5 .   ? 8.43123   -22.70570 2.86734   0.249 12.42956 ? 865  HOH A O   1 
HETATM 3972 O O   A HOH E 5 .   ? 41.748    -18.933   -15.297   0.542 13.00998 ? 866  HOH A O   1 
HETATM 3973 O O   B HOH E 5 .   ? 42.960    -18.320   -13.270   0.458 21.60849 ? 866  HOH A O   1 
HETATM 3974 O O   . HOH E 5 .   ? 12.13129  5.29896   -23.08245 1.000 9.76510  ? 867  HOH A O   1 
HETATM 3975 O O   . HOH E 5 .   ? 31.43190  -21.33190 -4.54738  1.000 9.98485  ? 868  HOH A O   1 
HETATM 3976 O O   A HOH E 5 .   ? 17.72886  8.03774   -21.38682 0.608 15.15653 ? 869  HOH A O   1 
HETATM 3977 O O   B HOH E 5 .   ? 16.90190  9.62466   -21.34895 0.392 17.90356 ? 869  HOH A O   1 
HETATM 3978 O O   . HOH E 5 .   ? 0.06553   -11.06913 -9.22801  1.000 12.68217 ? 870  HOH A O   1 
HETATM 3979 O O   A HOH E 5 .   ? 8.393     -26.552   4.675     0.582 15.12906 ? 871  HOH A O   1 
HETATM 3980 O O   B HOH E 5 .   ? 9.744     -27.608   4.631     0.418 20.17291 ? 871  HOH A O   1 
HETATM 3981 O O   . HOH E 5 .   ? 17.83690  -34.06021 -10.72282 1.000 19.69724 ? 872  HOH A O   1 
HETATM 3982 O O   A HOH E 5 .   ? 9.921     -30.308   1.268     0.549 15.79783 ? 873  HOH A O   1 
HETATM 3983 O O   B HOH E 5 .   ? 9.579     -31.696   0.318     0.451 17.55373 ? 873  HOH A O   1 
HETATM 3984 O O   A HOH E 5 .   ? 0.46198   -20.09642 -24.75410 0.656 13.12454 ? 874  HOH A O   1 
HETATM 3985 O O   B HOH E 5 .   ? 0.95453   -19.05326 -25.22094 0.344 14.21526 ? 874  HOH A O   1 
HETATM 3986 O O   . HOH E 5 .   ? 12.90511  -3.03666  -30.48553 1.000 9.15901  ? 875  HOH A O   1 
HETATM 3987 O O   . HOH E 5 .   ? -3.72690  -17.01044 -15.79018 1.000 13.62615 ? 876  HOH A O   1 
HETATM 3988 O O   . HOH E 5 .   ? 13.97252  -0.56645  -31.32522 1.000 9.25135  ? 877  HOH A O   1 
HETATM 3989 O O   . HOH E 5 .   ? 43.336    -19.378   -19.730   1.000 15.66971 ? 878  HOH A O   1 
HETATM 3990 O O   . HOH E 5 .   ? 7.54896   -10.83119 -10.64852 1.000 7.49410  ? 879  HOH A O   1 
HETATM 3991 O O   A HOH E 5 .   ? 15.859    1.769     3.431     0.764 11.50969 ? 880  HOH A O   1 
HETATM 3992 O O   B HOH E 5 .   ? 16.147    2.722     2.906     0.236 12.77943 ? 880  HOH A O   1 
HETATM 3993 O O   A HOH E 5 .   ? 21.03743  6.34393   -26.94149 0.890 9.17205  ? 881  HOH A O   1 
HETATM 3994 O O   B HOH E 5 .   ? 21.75934  6.21334   -26.59771 0.110 9.85338  ? 881  HOH A O   1 
HETATM 3995 O O   . HOH E 5 .   ? -0.14595  -20.37713 -15.52733 1.000 11.31160 ? 882  HOH A O   1 
HETATM 3996 O O   A HOH E 5 .   ? 10.36699  -3.05321  -6.16203  0.750 9.17240  ? 883  HOH A O   1 
HETATM 3997 O O   B HOH E 5 .   ? 8.76871   -2.98625  -6.32356  0.250 10.38919 ? 883  HOH A O   1 
HETATM 3998 O O   . HOH E 5 .   ? 19.04107  6.06417   -18.74012 1.000 13.60485 ? 884  HOH A O   1 
HETATM 3999 O O   . HOH E 5 .   ? 2.39714   -17.36559 -15.90319 1.000 7.98848  ? 885  HOH A O   1 
HETATM 4000 O O   . HOH E 5 .   ? 32.11069  1.95683   -3.29915  1.000 11.66735 ? 886  HOH A O   1 
HETATM 4001 O O   . HOH E 5 .   ? -10.16883 -8.40181  -14.36935 1.000 15.09018 ? 887  HOH A O   1 
HETATM 4002 O O   A HOH E 5 .   ? 16.75444  -1.82634  -40.03037 0.558 12.07589 ? 888  HOH A O   1 
HETATM 4003 O O   B HOH E 5 .   ? 14.63169  0.09887   -39.79009 0.442 7.87411  ? 888  HOH A O   1 
HETATM 4004 O O   . HOH E 5 .   ? 3.57871   -2.50235  -26.03247 1.000 10.80099 ? 889  HOH A O   1 
HETATM 4005 O O   . HOH E 5 .   ? 24.83002  -2.90617  6.20293   1.000 11.47354 ? 890  HOH A O   1 
HETATM 4006 O O   . HOH E 5 .   ? 33.60642  -20.56823 -32.24686 1.000 31.10623 ? 891  HOH A O   1 
HETATM 4007 O O   . HOH E 5 .   ? 11.59954  -25.24318 -27.06900 1.000 28.87690 ? 892  HOH A O   1 
HETATM 4008 O O   A HOH E 5 .   ? 40.84067  -21.46670 -9.02389  0.667 11.40235 ? 893  HOH A O   1 
HETATM 4009 O O   B HOH E 5 .   ? 40.58363  -22.58809 -9.87699  0.333 14.31106 ? 893  HOH A O   1 
HETATM 4010 O O   . HOH E 5 .   ? 27.999    -22.088   4.809     1.000 13.62010 ? 894  HOH A O   1 
HETATM 4011 O O   A HOH E 5 .   ? 7.55554   -10.42303 -21.52942 0.784 11.51504 ? 895  HOH A O   1 
HETATM 4012 O O   B HOH E 5 .   ? 7.56465   -9.67178  -21.96763 0.216 9.03170  ? 895  HOH A O   1 
HETATM 4013 O O   . HOH E 5 .   ? 33.51062  8.31463   -9.45195  1.000 22.36986 ? 896  HOH A O   1 
HETATM 4014 O O   A HOH E 5 .   ? 32.569    2.871     -24.229   0.623 13.69598 ? 897  HOH A O   1 
HETATM 4015 O O   B HOH E 5 .   ? 32.454    3.274     -22.613   0.377 12.82457 ? 897  HOH A O   1 
HETATM 4016 O O   . HOH E 5 .   ? 2.25577   7.57567   -25.19312 1.000 16.30958 ? 898  HOH A O   1 
HETATM 4017 O O   A HOH E 5 .   ? 23.10657  8.08353   -14.68890 0.454 16.76085 ? 899  HOH A O   1 
HETATM 4018 O O   B HOH E 5 .   ? 24.68383  7.46520   -16.62939 0.546 18.23730 ? 899  HOH A O   1 
HETATM 4019 O O   . HOH E 5 .   ? 33.77925  -22.19163 -28.01683 1.000 24.52650 ? 900  HOH A O   1 
HETATM 4020 O O   . HOH E 5 .   ? 43.50816  -14.28730 -11.20323 1.000 26.60342 ? 901  HOH A O   1 
HETATM 4021 O O   A HOH E 5 .   ? 26.52877  -26.78254 0.05050   0.727 15.77148 ? 902  HOH A O   1 
HETATM 4022 O O   B HOH E 5 .   ? 27.49831  -27.03414 -0.89837  0.273 15.42643 ? 902  HOH A O   1 
HETATM 4023 O O   A HOH E 5 .   ? 22.05357  -26.57714 -24.76267 0.680 14.86644 ? 903  HOH A O   1 
HETATM 4024 O O   B HOH E 5 .   ? 22.94392  -25.38752 -24.35722 0.320 14.09320 ? 903  HOH A O   1 
HETATM 4025 O O   A HOH E 5 .   ? 36.44904  -23.39171 -5.92164  0.343 16.50422 ? 904  HOH A O   1 
HETATM 4026 O O   B HOH E 5 .   ? 37.29664  -24.20893 -5.45656  0.657 9.51430  ? 904  HOH A O   1 
HETATM 4027 O O   . HOH E 5 .   ? 0.34527   -3.91512  -10.13621 1.000 11.84390 ? 905  HOH A O   1 
HETATM 4028 O O   A HOH E 5 .   ? 17.29941  4.41014   -8.33043  0.520 13.28172 ? 906  HOH A O   1 
HETATM 4029 O O   B HOH E 5 .   ? 14.14322  7.57535   -7.40229  0.480 17.27326 ? 906  HOH A O   1 
HETATM 4030 O O   . HOH E 5 .   ? 2.03101   -19.35290 -5.63318  1.000 17.13987 ? 907  HOH A O   1 
HETATM 4031 O O   . HOH E 5 .   ? 10.71999  0.66635   -4.05689  1.000 15.82101 ? 908  HOH A O   1 
HETATM 4032 O O   A HOH E 5 .   ? 12.610    13.364    -21.369   0.525 12.90982 ? 909  HOH A O   1 
HETATM 4033 O O   B HOH E 5 .   ? 11.574    13.364    -21.011   0.475 13.78294 ? 909  HOH A O   1 
HETATM 4034 O O   . HOH E 5 .   ? 15.874    11.609    -20.977   1.000 25.03023 ? 910  HOH A O   1 
HETATM 4035 O O   A HOH E 5 .   ? -5.43081  -5.47837  -14.21866 0.780 18.56953 ? 911  HOH A O   1 
HETATM 4036 O O   B HOH E 5 .   ? -5.34301  -5.48580  -15.26880 0.220 9.99431  ? 911  HOH A O   1 
HETATM 4037 O O   . HOH E 5 .   ? 13.00999  -25.40617 -25.04265 1.000 13.67768 ? 912  HOH A O   1 
HETATM 4038 O O   . HOH E 5 .   ? 12.21603  -7.06092  -21.72489 1.000 10.78220 ? 913  HOH A O   1 
HETATM 4039 O O   . HOH E 5 .   ? 1.65589   3.95052   -10.28034 1.000 16.61921 ? 914  HOH A O   1 
HETATM 4040 O O   . HOH E 5 .   ? 29.64376  -18.80368 -32.51712 1.000 23.82003 ? 915  HOH A O   1 
HETATM 4041 O O   . HOH E 5 .   ? 6.33498   -23.86202 -18.72607 1.000 15.52466 ? 916  HOH A O   1 
HETATM 4042 O O   . HOH E 5 .   ? 8.85631   -26.64761 -19.67199 1.000 22.33407 ? 917  HOH A O   1 
HETATM 4043 O O   A HOH E 5 .   ? 15.64424  -30.28878 2.70028   0.776 25.55343 ? 918  HOH A O   1 
HETATM 4044 O O   B HOH E 5 .   ? 14.39050  -30.72874 2.95110   0.224 22.27258 ? 918  HOH A O   1 
HETATM 4045 O O   . HOH E 5 .   ? -4.71883  -16.37364 -18.19513 1.000 12.65930 ? 919  HOH A O   1 
HETATM 4046 O O   . HOH E 5 .   ? 12.01203  -11.73780 -30.28217 1.000 11.39691 ? 920  HOH A O   1 
HETATM 4047 O O   . HOH E 5 .   ? 10.539    13.415    -31.577   1.000 16.12543 ? 921  HOH A O   1 
HETATM 4048 O O   . HOH E 5 .   ? -3.17280  1.12977   -18.72898 1.000 14.24985 ? 922  HOH A O   1 
HETATM 4049 O O   A HOH E 5 .   ? 26.00583  5.95269   -39.26858 0.731 18.91931 ? 923  HOH A O   1 
HETATM 4050 O O   B HOH E 5 .   ? 20.17383  7.23330   -35.49557 0.269 10.39744 ? 923  HOH A O   1 
HETATM 4051 O O   A HOH E 5 .   ? 24.71241  9.92130   -8.93747  0.621 11.39187 ? 924  HOH A O   1 
HETATM 4052 O O   B HOH E 5 .   ? 25.03131  10.44069  -8.24817  0.379 16.22219 ? 924  HOH A O   1 
HETATM 4053 O O   . HOH E 5 .   ? -6.37662  -11.11643 -32.20549 1.000 27.64700 ? 925  HOH A O   1 
HETATM 4054 O O   A HOH E 5 .   ? 18.82186  -5.00270  -31.33157 0.741 7.76045  ? 926  HOH A O   1 
HETATM 4055 O O   B HOH E 5 .   ? 18.83115  -2.83848  -31.28058 0.259 8.00179  ? 926  HOH A O   1 
HETATM 4056 O O   . HOH E 5 .   ? 16.86246  -35.78860 -14.52372 1.000 20.59290 ? 927  HOH A O   1 
HETATM 4057 O O   . HOH E 5 .   ? -13.02785 -12.42850 -23.41003 1.000 16.56031 ? 928  HOH A O   1 
HETATM 4058 O O   . HOH E 5 .   ? 6.72901   -6.34584  -8.56183  1.000 10.60591 ? 929  HOH A O   1 
HETATM 4059 O O   . HOH E 5 .   ? 33.62664  -24.20801 -6.89921  1.000 18.43421 ? 930  HOH A O   1 
HETATM 4060 O O   . HOH E 5 .   ? 37.634    -17.162   -4.181    1.000 9.99085  ? 931  HOH A O   1 
HETATM 4061 O O   . HOH E 5 .   ? 8.85381   -18.49297 -30.81603 1.000 12.98675 ? 932  HOH A O   1 
HETATM 4062 O O   . HOH E 5 .   ? -10.12472 -14.89012 -22.51542 1.000 21.40723 ? 933  HOH A O   1 
HETATM 4063 O O   . HOH E 5 .   ? 36.47119  2.11537   -9.23584  1.000 25.94876 ? 934  HOH A O   1 
HETATM 4064 O O   . HOH E 5 .   ? 2.76373   10.40672  -29.56671 1.000 18.01723 ? 935  HOH A O   1 
HETATM 4065 O O   A HOH E 5 .   ? 4.14512   14.49860  -14.85247 0.547 15.94094 ? 936  HOH A O   1 
HETATM 4066 O O   B HOH E 5 .   ? 2.34526   13.17275  -15.12885 0.453 18.29282 ? 936  HOH A O   1 
HETATM 4067 O O   . HOH E 5 .   ? 39.74766  -10.07045 -14.62738 1.000 15.57994 ? 937  HOH A O   1 
HETATM 4068 O O   . HOH E 5 .   ? 33.39543  0.32588   -29.30757 1.000 10.06364 ? 938  HOH A O   1 
HETATM 4069 O O   . HOH E 5 .   ? 11.865    -34.359   -20.076   1.000 26.63643 ? 939  HOH A O   1 
HETATM 4070 O O   A HOH E 5 .   ? 6.35359   14.04251  -21.98782 0.608 14.40382 ? 940  HOH A O   1 
HETATM 4071 O O   B HOH E 5 .   ? 5.21092   14.10006  -21.61327 0.392 17.54459 ? 940  HOH A O   1 
HETATM 4072 O O   . HOH E 5 .   ? 0.785     7.023     -29.641   1.000 20.44887 ? 941  HOH A O   1 
HETATM 4073 O O   . HOH E 5 .   ? 15.80091  -11.90498 -32.79738 1.000 15.02884 ? 942  HOH A O   1 
HETATM 4074 O O   . HOH E 5 .   ? 18.00664  -27.08304 -2.02579  1.000 22.25716 ? 943  HOH A O   1 
HETATM 4075 O O   . HOH E 5 .   ? 41.68971  -7.94898  -15.08295 1.000 18.10519 ? 944  HOH A O   1 
HETATM 4076 O O   A HOH E 5 .   ? 3.52611   -24.98489 -14.76157 0.509 8.66197  ? 945  HOH A O   1 
HETATM 4077 O O   B HOH E 5 .   ? 3.44942   -24.66277 -13.83303 0.491 9.96451  ? 945  HOH A O   1 
HETATM 4078 O O   . HOH E 5 .   ? 8.52703   15.25065  -22.87479 1.000 15.79312 ? 946  HOH A O   1 
HETATM 4079 O O   . HOH E 5 .   ? 11.95324  5.32708   -3.89625  1.000 29.88100 ? 947  HOH A O   1 
HETATM 4080 O O   A HOH E 5 .   ? 16.19012  -4.05901  -14.39690 0.492 13.75865 ? 948  HOH A O   1 
HETATM 4081 O O   B HOH E 5 .   ? 15.06184  -4.24703  -15.07304 0.508 14.09284 ? 948  HOH A O   1 
HETATM 4082 O O   . HOH E 5 .   ? 21.717    8.101     -39.740   1.000 15.88696 ? 949  HOH A O   1 
HETATM 4083 O O   A HOH E 5 .   ? 33.96713  0.68200   -19.50717 0.542 18.21136 ? 950  HOH A O   1 
HETATM 4084 O O   B HOH E 5 .   ? 33.21002  1.04986   -19.96104 0.458 11.57423 ? 950  HOH A O   1 
HETATM 4085 O O   . HOH E 5 .   ? 33.40598  -7.09588  -31.34772 1.000 13.22677 ? 951  HOH A O   1 
HETATM 4086 O O   A HOH E 5 .   ? 15.39665  12.18050  -14.85165 0.653 18.93157 ? 952  HOH A O   1 
HETATM 4087 O O   B HOH E 5 .   ? 14.42851  12.65831  -12.73674 0.347 13.90678 ? 952  HOH A O   1 
HETATM 4088 O O   . HOH E 5 .   ? 7.33404   6.01767   -5.78220  1.000 24.96169 ? 953  HOH A O   1 
HETATM 4089 O O   A HOH E 5 .   ? 2.38236   11.36126  -18.19716 0.482 16.61337 ? 954  HOH A O   1 
HETATM 4090 O O   B HOH E 5 .   ? 1.39277   11.69909  -19.05566 0.518 14.77594 ? 954  HOH A O   1 
HETATM 4091 O O   . HOH E 5 .   ? 39.50583  -11.41067 -17.08323 1.000 13.22241 ? 955  HOH A O   1 
HETATM 4092 O O   A HOH E 5 .   ? 35.01106  -1.16940  -14.48793 0.713 24.48422 ? 956  HOH A O   1 
HETATM 4093 O O   B HOH E 5 .   ? 35.11404  -0.21393  -16.19606 0.287 14.93818 ? 956  HOH A O   1 
HETATM 4094 O O   A HOH E 5 .   ? -11.48232 -3.04452  -28.80821 0.749 19.29820 ? 957  HOH A O   1 
HETATM 4095 O O   B HOH E 5 .   ? -10.98936 -3.49528  -29.97570 0.251 15.27391 ? 957  HOH A O   1 
HETATM 4096 O O   A HOH E 5 .   ? 5.60276   -29.30912 -1.17311  0.619 12.07113 ? 958  HOH A O   1 
HETATM 4097 O O   B HOH E 5 .   ? 4.66169   -29.26680 -1.75579  0.381 11.68331 ? 958  HOH A O   1 
HETATM 4098 O O   . HOH E 5 .   ? 26.88297  11.88820  -10.46144 1.000 8.06214  ? 959  HOH A O   1 
HETATM 4099 O O   . HOH E 5 .   ? 32.33489  6.00072   -1.18973  1.000 28.88660 ? 960  HOH A O   1 
HETATM 4100 O O   . HOH E 5 .   ? 34.57363  -13.84507 -31.95636 1.000 21.82601 ? 961  HOH A O   1 
HETATM 4101 O O   . HOH E 5 .   ? 0.42211   -30.54134 -7.64477  1.000 17.65025 ? 962  HOH A O   1 
HETATM 4102 O O   . HOH E 5 .   ? -14.18497 -5.13097  -28.92449 1.000 27.86000 ? 963  HOH A O   1 
HETATM 4103 O O   A HOH E 5 .   ? 1.97799   10.78554  -15.90973 0.529 18.26894 ? 964  HOH A O   1 
HETATM 4104 O O   B HOH E 5 .   ? 1.09952   10.59302  -14.67620 0.471 19.75530 ? 964  HOH A O   1 
HETATM 4105 O O   . HOH E 5 .   ? 40.39492  -7.18622  -11.27217 1.000 34.84461 ? 965  HOH A O   1 
HETATM 4106 O O   . HOH E 5 .   ? 8.58410   7.95977   -30.97419 1.000 22.40484 ? 966  HOH A O   1 
HETATM 4107 O O   . HOH E 5 .   ? 29.59565  -12.49652 -34.58706 1.000 24.16689 ? 967  HOH A O   1 
HETATM 4108 O O   A HOH E 5 .   ? 25.34065  -3.00618  8.96041   0.607 11.35088 ? 968  HOH A O   1 
HETATM 4109 O O   B HOH E 5 .   ? 23.71470  -2.55677  12.18169  0.393 8.42980  ? 968  HOH A O   1 
HETATM 4110 O O   . HOH E 5 .   ? 14.94141  -9.03661  -36.35533 1.000 25.32913 ? 969  HOH A O   1 
HETATM 4111 O O   . HOH E 5 .   ? 10.309    -34.963   -18.207   1.000 23.20992 ? 970  HOH A O   1 
HETATM 4112 O O   . HOH E 5 .   ? 22.43489  7.33189   -2.40046  1.000 31.84031 ? 971  HOH A O   1 
HETATM 4113 O O   . HOH E 5 .   ? 33.064    -9.859    -1.613    1.000 12.94486 ? 972  HOH A O   1 
HETATM 4114 O O   A HOH E 5 .   ? 13.69195  3.20949   -36.09322 0.564 12.42160 ? 973  HOH A O   1 
HETATM 4115 O O   B HOH E 5 .   ? 12.39888  4.18428   -35.45839 0.436 16.84848 ? 973  HOH A O   1 
HETATM 4116 O O   . HOH E 5 .   ? 18.64929  -9.05486  9.61923   1.000 23.69749 ? 974  HOH A O   1 
HETATM 4117 O O   . HOH E 5 .   ? 33.03531  -11.66115 -32.60755 1.000 17.67134 ? 975  HOH A O   1 
HETATM 4118 O O   . HOH E 5 .   ? 16.80943  -38.53425 -14.02154 1.000 26.85089 ? 976  HOH A O   1 
HETATM 4119 O O   . HOH E 5 .   ? 21.31189  4.06243   -39.21353 1.000 23.95461 ? 977  HOH A O   1 
HETATM 4120 O O   . HOH E 5 .   ? 25.60388  7.72097   -2.86749  1.000 24.31712 ? 978  HOH A O   1 
HETATM 4121 O O   . HOH E 5 .   ? -4.963    -19.447   -19.301   1.000 27.79581 ? 979  HOH A O   1 
HETATM 4122 O O   . HOH E 5 .   ? 14.25598  -9.95960  -34.34864 1.000 27.04641 ? 980  HOH A O   1 
HETATM 4123 O O   . HOH E 5 .   ? 23.80342  -22.74213 3.15614   1.000 24.93360 ? 981  HOH A O   1 
HETATM 4124 O O   . HOH E 5 .   ? 3.05032   -28.42207 -16.28530 1.000 23.75204 ? 982  HOH A O   1 
HETATM 4125 O O   A HOH E 5 .   ? 5.14253   11.25924  -26.34793 0.488 11.76797 ? 983  HOH A O   1 
HETATM 4126 O O   B HOH E 5 .   ? 3.36957   12.89657  -25.22812 0.277 7.58085  ? 983  HOH A O   1 
HETATM 4127 O O   C HOH E 5 .   ? 3.64318   11.60242  -25.65217 0.235 12.30288 ? 983  HOH A O   1 
HETATM 4128 O O   . HOH E 5 .   ? 15.90595  -34.03796 -3.96639  1.000 22.79543 ? 984  HOH A O   1 
HETATM 4129 O O   A HOH E 5 .   ? 35.728    0.928     -18.331   0.721 23.60352 ? 985  HOH A O   1 
HETATM 4130 O O   B HOH E 5 .   ? 36.936    0.622     -18.522   0.279 10.83050 ? 985  HOH A O   1 
HETATM 4131 O O   . HOH E 5 .   ? 26.72594  3.59267   5.90264   1.000 16.94270 ? 986  HOH A O   1 
HETATM 4132 O O   . HOH E 5 .   ? 34.096    -25.442   -18.133   1.000 12.29210 ? 987  HOH A O   1 
HETATM 4133 O O   . HOH E 5 .   ? 43.084    -13.799   -20.231   1.000 28.06473 ? 988  HOH A O   1 
HETATM 4134 O O   . HOH E 5 .   ? 15.013    6.500     5.298     1.000 17.63241 ? 989  HOH A O   1 
HETATM 4135 O O   A HOH E 5 .   ? 33.34864  -7.67102  -3.31100  0.563 11.60092 ? 990  HOH A O   1 
HETATM 4136 O O   B HOH E 5 .   ? 33.10245  -7.76236  -2.44757  0.437 10.71303 ? 990  HOH A O   1 
HETATM 4137 O O   . HOH E 5 .   ? 22.19189  -28.39648 -2.03201  1.000 28.36176 ? 991  HOH A O   1 
HETATM 4138 O O   . HOH E 5 .   ? 36.146    0.009     -29.990   1.000 14.61259 ? 992  HOH A O   1 
HETATM 4139 O O   . HOH E 5 .   ? 9.94581   6.45603   -31.98166 1.000 23.17652 ? 993  HOH A O   1 
HETATM 4140 O O   . HOH E 5 .   ? 28.71316  -23.79723 -3.07378  1.000 16.40019 ? 994  HOH A O   1 
HETATM 4141 O O   . HOH E 5 .   ? 0.59511   -20.30991 -12.80386 1.000 14.35746 ? 995  HOH A O   1 
HETATM 4142 O O   A HOH E 5 .   ? 16.66104  -16.92525 7.04476   0.381 20.39487 ? 996  HOH A O   1 
HETATM 4143 O O   B HOH E 5 .   ? 15.83256  -16.23042 8.44642   0.619 14.38441 ? 996  HOH A O   1 
HETATM 4144 O O   . HOH E 5 .   ? 5.03375   -4.27260  -7.87741  1.000 15.49009 ? 997  HOH A O   1 
HETATM 4145 O O   A HOH E 5 .   ? 15.629    -6.009    8.328     0.655 20.05588 ? 998  HOH A O   1 
HETATM 4146 O O   B HOH E 5 .   ? 15.506    -5.773    9.776     0.345 11.78981 ? 998  HOH A O   1 
HETATM 4147 O O   . HOH E 5 .   ? 0.75365   1.41150   -24.11779 1.000 25.14139 ? 999  HOH A O   1 
HETATM 4148 O O   A HOH E 5 .   ? 14.69735  -28.44315 -22.77124 0.599 18.47116 ? 1000 HOH A O   1 
HETATM 4149 O O   B HOH E 5 .   ? 13.14299  -28.09669 -24.90098 0.401 19.96995 ? 1000 HOH A O   1 
HETATM 4150 O O   A HOH E 5 .   ? 26.72803  5.65868   -0.81560  0.505 19.30263 ? 1001 HOH A O   1 
HETATM 4151 O O   B HOH E 5 .   ? 23.80741  5.63327   -0.44429  0.495 14.77093 ? 1001 HOH A O   1 
HETATM 4152 O O   . HOH E 5 .   ? 6.46859   3.07022   -5.75678  1.000 29.18620 ? 1002 HOH A O   1 
HETATM 4153 O O   . HOH E 5 .   ? 2.62805   -30.21801 -18.34336 1.000 24.62721 ? 1003 HOH A O   1 
HETATM 4154 O O   . HOH E 5 .   ? 18.42460  7.23854   -37.49518 1.000 15.65946 ? 1004 HOH A O   1 
HETATM 4155 O O   . HOH E 5 .   ? 0.90746   5.61912   -25.35358 1.000 25.38038 ? 1005 HOH A O   1 
HETATM 4156 O O   . HOH E 5 .   ? 41.007    -18.533   -29.516   1.000 29.15643 ? 1006 HOH A O   1 
HETATM 4157 O O   . HOH E 5 .   ? 32.85467  3.06791   -1.08020  1.000 27.94603 ? 1007 HOH A O   1 
HETATM 4158 O O   . HOH E 5 .   ? 33.520    -23.058   -4.354    1.000 12.12857 ? 1008 HOH A O   1 
HETATM 4159 O O   . HOH E 5 .   ? 8.18551   1.24987   -4.67701  1.000 23.57844 ? 1009 HOH A O   1 
HETATM 4160 O O   . HOH E 5 .   ? 9.40381   -23.76935 -22.82083 1.000 18.10038 ? 1010 HOH A O   1 
HETATM 4161 O O   . HOH E 5 .   ? 31.30106  -16.73664 -32.96487 1.000 22.83064 ? 1011 HOH A O   1 
HETATM 4162 O O   . HOH E 5 .   ? 17.905    -5.683    -47.047   1.000 27.87037 ? 1012 HOH A O   1 
HETATM 4163 O O   A HOH E 5 .   ? 24.02391  -4.71678  10.63483  0.633 13.17124 ? 1013 HOH A O   1 
HETATM 4164 O O   B HOH E 5 .   ? 22.58958  -4.85627  11.48228  0.367 17.90758 ? 1013 HOH A O   1 
HETATM 4165 O O   A HOH E 5 .   ? 23.13706  4.60861   -26.73662 0.712 13.16552 ? 1014 HOH A O   1 
HETATM 4166 O O   B HOH E 5 .   ? 24.76976  3.55306   -26.67290 0.288 16.28649 ? 1014 HOH A O   1 
HETATM 4167 O O   . HOH E 5 .   ? 12.86834  -26.80919 -21.39251 1.000 21.13927 ? 1015 HOH A O   1 
HETATM 4168 O O   . HOH E 5 .   ? 10.70301  1.82742   -1.55003  1.000 22.18385 ? 1016 HOH A O   1 
HETATM 4169 O O   . HOH E 5 .   ? -1.51386  1.83244   -16.22936 1.000 16.83027 ? 1017 HOH A O   1 
HETATM 4170 O O   . HOH E 5 .   ? 13.72921  -17.01454 7.08798   1.000 16.62985 ? 1018 HOH A O   1 
HETATM 4171 O O   . HOH E 5 .   ? -2.04356  2.02094   -13.37443 1.000 26.92523 ? 1019 HOH A O   1 
HETATM 4172 O O   . HOH E 5 .   ? 27.996    -16.837   5.543     1.000 22.54403 ? 1020 HOH A O   1 
HETATM 4173 O O   . HOH E 5 .   ? 25.17944  6.03133   1.25565   1.000 26.63568 ? 1021 HOH A O   1 
HETATM 4174 O O   . HOH E 5 .   ? 0.08121   -8.34784  -8.37169  1.000 16.14034 ? 1022 HOH A O   1 
HETATM 4175 O O   . HOH E 5 .   ? 43.472    -18.359   -17.083   1.000 20.65294 ? 1023 HOH A O   1 
HETATM 4176 O O   A HOH E 5 .   ? -5.07730  -17.73615 -13.44488 0.547 14.98296 ? 1024 HOH A O   1 
HETATM 4177 O O   B HOH E 5 .   ? -4.08016  -16.96964 -12.10157 0.453 16.75535 ? 1024 HOH A O   1 
HETATM 4178 O O   . HOH E 5 .   ? 19.635    6.241     -39.759   1.000 14.55745 ? 1025 HOH A O   1 
HETATM 4179 O O   . HOH E 5 .   ? -6.15384  0.60268   -19.61153 1.000 26.01626 ? 1026 HOH A O   1 
HETATM 4180 O O   . HOH E 5 .   ? 2.53733   -8.66637  -36.15235 1.000 27.21804 ? 1027 HOH A O   1 
HETATM 4181 O O   . HOH E 5 .   ? 1.735     -36.575   -4.919    1.000 25.25238 ? 1028 HOH A O   1 
HETATM 4182 O O   . HOH E 5 .   ? 19.395    -36.868   -9.314    1.000 25.55140 ? 1029 HOH A O   1 
HETATM 4183 O O   . HOH E 5 .   ? 3.26414   -9.28066  -1.63766  1.000 26.70258 ? 1030 HOH A O   1 
HETATM 4184 O O   A HOH E 5 .   ? 1.088     2.000     -29.726   0.757 19.95640 ? 1031 HOH A O   1 
HETATM 4185 O O   B HOH E 5 .   ? 1.568     1.306     -30.839   0.243 16.83669 ? 1031 HOH A O   1 
HETATM 4186 O O   . HOH E 5 .   ? -5.97329  -15.75550 -11.38768 1.000 24.17976 ? 1032 HOH A O   1 
HETATM 4187 O O   . HOH E 5 .   ? 10.17701  -2.17115  -3.63512  1.000 15.27339 ? 1033 HOH A O   1 
HETATM 4188 O O   . HOH E 5 .   ? -0.72539  6.11943   -14.63345 1.000 19.39918 ? 1034 HOH A O   1 
HETATM 4189 O O   . HOH E 5 .   ? 0.641     10.575    -27.854   1.000 13.80740 ? 1035 HOH A O   1 
HETATM 4190 O O   . HOH E 5 .   ? 20.03710  -15.16078 9.75011   1.000 29.90667 ? 1036 HOH A O   1 
HETATM 4191 O O   . HOH E 5 .   ? 38.615    -15.052   -29.826   1.000 26.80218 ? 1037 HOH A O   1 
HETATM 4192 O O   A HOH E 5 .   ? 24.78819  -13.27415 -36.55275 0.755 26.36434 ? 1038 HOH A O   1 
HETATM 4193 O O   B HOH E 5 .   ? 24.28437  -15.28542 -36.38971 0.245 20.19459 ? 1038 HOH A O   1 
HETATM 4194 O O   . HOH E 5 .   ? 26.28713  5.60220   3.71096   1.000 21.42508 ? 1039 HOH A O   1 
HETATM 4195 O O   A HOH E 5 .   ? 21.62103  -6.08712  10.46471  0.538 13.28431 ? 1040 HOH A O   1 
HETATM 4196 O O   B HOH E 5 .   ? 20.73241  -7.76910  10.70709  0.462 22.82072 ? 1040 HOH A O   1 
HETATM 4197 O O   . HOH E 5 .   ? 12.15752  -24.13091 -22.73711 1.000 13.20105 ? 1041 HOH A O   1 
HETATM 4198 O O   . HOH E 5 .   ? 12.41676  -35.41131 -8.26621  1.000 24.27894 ? 1042 HOH A O   1 
HETATM 4199 O O   . HOH E 5 .   ? 10.96191  -13.75806 -34.87577 1.000 20.17513 ? 1043 HOH A O   1 
HETATM 4200 O O   . HOH E 5 .   ? 0.12356   -12.82179 -7.15659  1.000 19.33310 ? 1044 HOH A O   1 
HETATM 4201 O O   . HOH E 5 .   ? 1.636     6.819     -32.222   1.000 22.86522 ? 1045 HOH A O   1 
HETATM 4202 O O   . HOH E 5 .   ? 19.43075  -18.98817 7.40717   1.000 26.02252 ? 1046 HOH A O   1 
HETATM 4203 O O   . HOH E 5 .   ? 0.77084   11.43034  -6.75157  1.000 34.97235 ? 1047 HOH A O   1 
HETATM 4204 O O   . HOH E 5 .   ? 14.66393  -7.41595  -42.41432 1.000 29.80902 ? 1048 HOH A O   1 
HETATM 4205 O O   . HOH E 5 .   ? 34.92877  1.96275   -4.38659  1.000 27.69306 ? 1049 HOH A O   1 
HETATM 4206 O O   . HOH E 5 .   ? -0.26275  4.06590   -23.42586 1.000 17.27077 ? 1050 HOH A O   1 
HETATM 4207 O O   . HOH E 5 .   ? 13.73462  -16.73111 -34.44536 1.000 28.83898 ? 1051 HOH A O   1 
HETATM 4208 O O   A HOH E 5 .   ? 13.95922  8.74402   -34.74759 0.618 17.23710 ? 1052 HOH A O   1 
HETATM 4209 O O   B HOH E 5 .   ? 14.83624  7.54079   -36.11463 0.382 19.45086 ? 1052 HOH A O   1 
HETATM 4210 O O   A HOH E 5 .   ? 45.267    -17.294   -22.751   0.767 15.48938 ? 1053 HOH A O   1 
HETATM 4211 O O   B HOH E 5 .   ? 45.311    -18.693   -22.863   0.233 16.04968 ? 1053 HOH A O   1 
HETATM 4212 O O   A HOH E 5 .   ? 17.279    -0.550    -42.440   0.519 12.88861 ? 1054 HOH A O   1 
HETATM 4213 O O   B HOH E 5 .   ? 17.655    2.213     -42.209   0.481 9.75767  ? 1054 HOH A O   1 
HETATM 4214 O O   . HOH E 5 .   ? 2.27506   -4.25874  -7.97217  1.000 14.90445 ? 1055 HOH A O   1 
HETATM 4215 O O   . HOH E 5 .   ? 22.107    7.282     -29.330   1.000 14.08839 ? 1056 HOH A O   1 
HETATM 4216 O O   . HOH E 5 .   ? 14.361    -35.356   -21.144   1.000 15.63713 ? 1057 HOH A O   1 
HETATM 4217 O O   A HOH E 5 .   ? -0.55343  -38.58404 -8.28723  0.743 18.37814 ? 1058 HOH A O   1 
HETATM 4218 O O   B HOH E 5 .   ? 0.38096   -38.90437 -9.64231  0.257 16.54652 ? 1058 HOH A O   1 
HETATM 4219 O O   . HOH E 5 .   ? 43.980    -10.771   -12.223   1.000 30.51384 ? 1059 HOH A O   1 
HETATM 4220 O O   . HOH E 5 .   ? -4.68825  -2.87189  -14.06588 1.000 18.13072 ? 1060 HOH A O   1 
HETATM 4221 O O   . HOH E 5 .   ? 8.43919   -2.25736  -1.60996  1.000 21.32129 ? 1061 HOH A O   1 
HETATM 4222 O O   . HOH E 5 .   ? 27.84780  -3.27687  -38.66627 1.000 28.83139 ? 1062 HOH A O   1 
HETATM 4223 O O   A HOH E 5 .   ? 14.19069  -1.20556  -16.50915 0.631 12.39396 ? 1063 HOH A O   1 
HETATM 4224 O O   B HOH E 5 .   ? 14.83479  -0.46282  -15.15541 0.369 6.64759  ? 1063 HOH A O   1 
HETATM 4225 O O   . HOH E 5 .   ? 34.65146  -9.71641  -31.47801 1.000 14.32864 ? 1064 HOH A O   1 
HETATM 4226 O O   . HOH E 5 .   ? -17.29508 -8.47633  -28.90293 1.000 15.82994 ? 1065 HOH A O   1 
HETATM 4227 O O   . HOH E 5 .   ? 34.01389  -0.69747  -33.67711 1.000 18.14058 ? 1066 HOH A O   1 
HETATM 4228 O O   . HOH E 5 .   ? 15.98393  -15.13861 -33.29286 1.000 24.70065 ? 1067 HOH A O   1 
HETATM 4229 O O   . HOH E 5 .   ? 7.69340   -24.60622 -20.83167 1.000 18.46160 ? 1068 HOH A O   1 
HETATM 4230 O O   . HOH E 5 .   ? 27.484    -7.818    9.027     1.000 23.21320 ? 1069 HOH A O   1 
HETATM 4231 O O   . HOH E 5 .   ? -1.91553  -8.29262  -6.52189  1.000 23.52717 ? 1070 HOH A O   1 
HETATM 4232 O O   . HOH E 5 .   ? -1.77993  -2.28287  -9.74870  1.000 33.27644 ? 1071 HOH A O   1 
HETATM 4233 O O   . HOH E 5 .   ? 2.24174   -21.76118 -25.38148 1.000 26.63181 ? 1072 HOH A O   1 
HETATM 4234 O O   . HOH E 5 .   ? 35.27394  -2.37077  -5.13412  1.000 22.62745 ? 1073 HOH A O   1 
HETATM 4235 O O   . HOH E 5 .   ? 34.50602  -18.30517 -30.55408 1.000 20.18749 ? 1074 HOH A O   1 
HETATM 4236 O O   . HOH E 5 .   ? -3.31370  3.68638   -19.83122 1.000 20.47160 ? 1075 HOH A O   1 
HETATM 4237 O O   A HOH E 5 .   ? 30.754    -25.542   -15.754   0.258 8.17478  ? 1076 HOH A O   1 
HETATM 4238 O O   B HOH E 5 .   ? 31.243    -22.824   -15.839   0.742 12.27101 ? 1076 HOH A O   1 
HETATM 4239 O O   . HOH E 5 .   ? 24.558    5.084     -29.052   1.000 12.68158 ? 1077 HOH A O   1 
HETATM 4240 O O   . HOH E 5 .   ? 37.11048  -3.94974  -6.80385  1.000 37.87394 ? 1078 HOH A O   1 
HETATM 4241 O O   . HOH E 5 .   ? 16.06136  -8.68607  -44.47632 1.000 28.43604 ? 1079 HOH A O   1 
HETATM 4242 O O   . HOH E 5 .   ? 13.28041  -12.76178 -36.06547 1.000 27.16722 ? 1080 HOH A O   1 
HETATM 4243 O O   . HOH E 5 .   ? 7.96189   13.62090  -31.29392 1.000 21.03525 ? 1081 HOH A O   1 
HETATM 4244 O O   . HOH E 5 .   ? -2.75432  -19.72214 -15.60174 1.000 14.24833 ? 1082 HOH A O   1 
HETATM 4245 O O   . HOH E 5 .   ? 27.34627  2.01308   -39.61998 1.000 25.02807 ? 1083 HOH A O   1 
HETATM 4246 O O   . HOH E 5 .   ? 35.96600  -6.32430  -30.51436 1.000 17.79741 ? 1084 HOH A O   1 
HETATM 4247 O O   . HOH E 5 .   ? 34.69261  3.75115   -8.42537  1.000 26.33578 ? 1085 HOH A O   1 
HETATM 4248 O O   . HOH E 5 .   ? -3.71680  5.13483   -17.56083 1.000 24.09988 ? 1086 HOH A O   1 
HETATM 4249 O O   . HOH E 5 .   ? 8.35171   -25.19835 -24.99214 1.000 31.90906 ? 1087 HOH A O   1 
HETATM 4250 O O   A HOH E 5 .   ? 14.46229  -7.04440  5.70451   0.538 11.55890 ? 1088 HOH A O   1 
HETATM 4251 O O   B HOH E 5 .   ? 14.68052  -5.80713  5.83814   0.462 16.31207 ? 1088 HOH A O   1 
HETATM 4252 O O   A HOH E 5 .   ? 8.14043   14.86372  -26.61552 0.503 10.54523 ? 1089 HOH A O   1 
HETATM 4253 O O   B HOH E 5 .   ? 8.58585   16.40569  -27.48219 0.497 21.76900 ? 1089 HOH A O   1 
HETATM 4254 O O   . HOH E 5 .   ? 9.90689   -18.06918 -33.39831 1.000 20.53648 ? 1090 HOH A O   1 
HETATM 4255 O O   A HOH E 5 .   ? 1.124     -24.452   -13.641   0.590 12.86414 ? 1091 HOH A O   1 
HETATM 4256 O O   B HOH E 5 .   ? 0.820     -25.095   -14.753   0.410 16.76491 ? 1091 HOH A O   1 
HETATM 4257 O O   A HOH E 5 .   ? 0.82402   -22.80350 -9.25966  0.532 16.73655 ? 1092 HOH A O   1 
HETATM 4258 O O   C HOH E 5 .   ? 0.63609   -23.68641 -10.05447 0.468 13.28462 ? 1092 HOH A O   1 
HETATM 4259 O O   . HOH E 5 .   ? -1.60197  -20.03297 -11.26152 1.000 19.51668 ? 1093 HOH A O   1 
HETATM 4260 O O   . HOH E 5 .   ? 36.76278  -13.12692 -30.51104 1.000 16.01234 ? 1094 HOH A O   1 
HETATM 4261 O O   . HOH E 5 .   ? 18.49522  -16.93891 8.39433   1.000 28.83223 ? 1095 HOH A O   1 
HETATM 4262 O O   . HOH E 5 .   ? 8.154     -29.231   3.283     1.000 17.90536 ? 1096 HOH A O   1 
HETATM 4263 O O   . HOH E 5 .   ? 36.53649  -0.13781  -4.93671  1.000 31.90426 ? 1097 HOH A O   1 
HETATM 4264 O O   . HOH E 5 .   ? -2.76771  -7.03079  -11.53360 1.000 17.90996 ? 1098 HOH A O   1 
HETATM 4265 O O   . HOH E 5 .   ? 5.21110   -25.05731 -23.30028 1.000 30.19726 ? 1099 HOH A O   1 
HETATM 4266 O O   . HOH E 5 .   ? 12.27032  -20.33871 -31.70242 1.000 23.59905 ? 1100 HOH A O   1 
HETATM 4267 O O   . HOH E 5 .   ? -7.46140  -16.75704 -18.21757 1.000 13.43111 ? 1101 HOH A O   1 
HETATM 4268 O O   A HOH E 5 .   ? -1.977    7.313     -26.490   0.662 21.99875 ? 1102 HOH A O   1 
HETATM 4269 O O   B HOH E 5 .   ? -3.411    7.623     -25.818   0.338 17.01662 ? 1102 HOH A O   1 
HETATM 4270 O O   . HOH E 5 .   ? 6.75598   -20.06696 -31.37750 1.000 20.95593 ? 1103 HOH A O   1 
HETATM 4271 O O   . HOH E 5 .   ? 4.26128   -6.66328  -2.14893  1.000 24.19453 ? 1104 HOH A O   1 
HETATM 4272 O O   . HOH E 5 .   ? 2.052     10.438    -32.209   1.000 28.54885 ? 1105 HOH A O   1 
HETATM 4273 O O   . HOH E 5 .   ? 5.96318   -20.95352 -24.88577 1.000 19.84359 ? 1106 HOH A O   1 
HETATM 4274 O O   . HOH E 5 .   ? 26.10143  -24.07948 4.19625   1.000 17.08953 ? 1107 HOH A O   1 
HETATM 4275 O O   A HOH E 5 .   ? 4.49892   -20.45440 -26.73272 0.693 21.14349 ? 1108 HOH A O   1 
HETATM 4276 O O   B HOH E 5 .   ? 3.43126   -19.35851 -27.04330 0.307 18.71599 ? 1108 HOH A O   1 
HETATM 4277 O O   . HOH E 5 .   ? 27.60298  -25.59200 2.35083   1.000 20.21007 ? 1109 HOH A O   1 
HETATM 4278 O O   A HOH E 5 .   ? 15.91857  5.45682   -37.17526 0.449 13.31280 ? 1110 HOH A O   1 
HETATM 4279 O O   B HOH E 5 .   ? 14.85594  4.54944   -39.39865 0.551 12.12338 ? 1110 HOH A O   1 
HETATM 4280 O O   . HOH E 5 .   ? 19.31000  -31.46621 0.56097   1.000 27.79592 ? 1111 HOH A O   1 
HETATM 4281 O O   . HOH E 5 .   ? 2.26881   2.38699   -7.07636  1.000 31.82473 ? 1112 HOH A O   1 
HETATM 4282 O O   . HOH E 5 .   ? 25.27567  7.99167   4.56303   1.000 28.74683 ? 1113 HOH A O   1 
HETATM 4283 O O   . HOH E 5 .   ? -16.077   -11.635   -32.307   1.000 28.72739 ? 1114 HOH A O   1 
HETATM 4284 O O   A HOH E 5 .   ? 18.01706  -34.58200 -2.07037  0.630 22.86334 ? 1115 HOH A O   1 
HETATM 4285 O O   B HOH E 5 .   ? 19.98673  -33.61589 -2.92757  0.370 17.91096 ? 1115 HOH A O   1 
HETATM 4286 O O   . HOH E 5 .   ? -1.833    10.615    -15.421   1.000 24.60184 ? 1116 HOH A O   1 
HETATM 4287 O O   . HOH E 5 .   ? 4.55525   -4.94429  0.22418   1.000 34.84112 ? 1117 HOH A O   1 
HETATM 4288 O O   . HOH E 5 .   ? -3.87429  -19.93908 -13.16923 1.000 22.31780 ? 1118 HOH A O   1 
HETATM 4289 O O   . HOH E 5 .   ? 1.64631   -2.10467  -6.20554  1.000 26.90154 ? 1119 HOH A O   1 
HETATM 4290 O O   . HOH E 5 .   ? -2.76431  8.54299   -15.08729 1.000 26.80234 ? 1120 HOH A O   1 
# 
