data_8YKQ
# 
_entry.id   8YKQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YKQ         pdb_00008ykq 10.2210/pdb8ykq/pdb 
WWPDB D_1300043868 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YKQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rmsl_2040@163.com 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9511-4219 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zou, X.F.' 1 ? 
'Zhang, J.' 2 ? 
'Li, J.'    3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            276 
_citation.language                  ? 
_citation.page_first                133706 
_citation.page_last                 133706 
_citation.title                     
'Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.133706 
_citation.pdbx_database_id_PubMed   38981557 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jiang, H.' 1 ? 
primary 'Li, W.'    2 ? 
primary 'Zhou, X.'  3 ? 
primary 'Zhang, J.' 4 ? 
primary 'Li, J.'    5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                                    
33196.875 1  3.4.22.69 V186F ? ? 
2 non-polymer syn 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' 
459.583   1  ?         ?     ? ? 
3 water       nat water                                                                                                        
18.015    51 ?         ?     ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFFDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFFDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' X77 
3 water                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PHE n 
1 2   ARG n 
1 3   LYS n 
1 4   MET n 
1 5   ALA n 
1 6   PHE n 
1 7   PRO n 
1 8   SER n 
1 9   GLY n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  GLY n 
1 14  CYS n 
1 15  MET n 
1 16  VAL n 
1 17  GLN n 
1 18  VAL n 
1 19  THR n 
1 20  CYS n 
1 21  GLY n 
1 22  THR n 
1 23  THR n 
1 24  THR n 
1 25  LEU n 
1 26  ASN n 
1 27  GLY n 
1 28  LEU n 
1 29  TRP n 
1 30  LEU n 
1 31  ASP n 
1 32  ASP n 
1 33  VAL n 
1 34  VAL n 
1 35  TYR n 
1 36  CYS n 
1 37  PRO n 
1 38  ARG n 
1 39  HIS n 
1 40  VAL n 
1 41  ILE n 
1 42  CYS n 
1 43  THR n 
1 44  SER n 
1 45  GLU n 
1 46  ASP n 
1 47  MET n 
1 48  LEU n 
1 49  ASN n 
1 50  PRO n 
1 51  ASN n 
1 52  TYR n 
1 53  GLU n 
1 54  ASP n 
1 55  LEU n 
1 56  LEU n 
1 57  ILE n 
1 58  ARG n 
1 59  LYS n 
1 60  SER n 
1 61  ASN n 
1 62  HIS n 
1 63  ASN n 
1 64  PHE n 
1 65  LEU n 
1 66  VAL n 
1 67  GLN n 
1 68  ALA n 
1 69  GLY n 
1 70  ASN n 
1 71  VAL n 
1 72  GLN n 
1 73  LEU n 
1 74  ARG n 
1 75  VAL n 
1 76  ILE n 
1 77  GLY n 
1 78  HIS n 
1 79  SER n 
1 80  MET n 
1 81  GLN n 
1 82  ASN n 
1 83  CYS n 
1 84  VAL n 
1 85  LEU n 
1 86  LYS n 
1 87  LEU n 
1 88  LYS n 
1 89  VAL n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  ASN n 
1 94  PRO n 
1 95  LYS n 
1 96  THR n 
1 97  PRO n 
1 98  LYS n 
1 99  TYR n 
1 100 LYS n 
1 101 PHE n 
1 102 VAL n 
1 103 ARG n 
1 104 ILE n 
1 105 GLN n 
1 106 PRO n 
1 107 GLY n 
1 108 GLN n 
1 109 THR n 
1 110 PHE n 
1 111 SER n 
1 112 VAL n 
1 113 LEU n 
1 114 ALA n 
1 115 CYS n 
1 116 TYR n 
1 117 ASN n 
1 118 GLY n 
1 119 SER n 
1 120 PRO n 
1 121 SER n 
1 122 GLY n 
1 123 VAL n 
1 124 TYR n 
1 125 GLN n 
1 126 CYS n 
1 127 ALA n 
1 128 MET n 
1 129 ARG n 
1 130 PRO n 
1 131 ASN n 
1 132 PHE n 
1 133 THR n 
1 134 ILE n 
1 135 LYS n 
1 136 GLY n 
1 137 SER n 
1 138 PHE n 
1 139 LEU n 
1 140 ASN n 
1 141 GLY n 
1 142 SER n 
1 143 CYS n 
1 144 GLY n 
1 145 SER n 
1 146 VAL n 
1 147 GLY n 
1 148 PHE n 
1 149 ASN n 
1 150 ILE n 
1 151 ASP n 
1 152 TYR n 
1 153 ASP n 
1 154 CYS n 
1 155 VAL n 
1 156 SER n 
1 157 PHE n 
1 158 CYS n 
1 159 TYR n 
1 160 MET n 
1 161 HIS n 
1 162 HIS n 
1 163 MET n 
1 164 GLU n 
1 165 LEU n 
1 166 PRO n 
1 167 THR n 
1 168 GLY n 
1 169 VAL n 
1 170 HIS n 
1 171 ALA n 
1 172 GLY n 
1 173 THR n 
1 174 ASP n 
1 175 LEU n 
1 176 GLU n 
1 177 GLY n 
1 178 ASN n 
1 179 PHE n 
1 180 TYR n 
1 181 GLY n 
1 182 PRO n 
1 183 PHE n 
1 184 PHE n 
1 185 ASP n 
1 186 ARG n 
1 187 GLN n 
1 188 THR n 
1 189 ALA n 
1 190 GLN n 
1 191 ALA n 
1 192 ALA n 
1 193 GLY n 
1 194 THR n 
1 195 ASP n 
1 196 THR n 
1 197 THR n 
1 198 ILE n 
1 199 THR n 
1 200 VAL n 
1 201 ASN n 
1 202 VAL n 
1 203 LEU n 
1 204 ALA n 
1 205 TRP n 
1 206 LEU n 
1 207 TYR n 
1 208 ALA n 
1 209 ALA n 
1 210 VAL n 
1 211 ILE n 
1 212 ASN n 
1 213 GLY n 
1 214 ASP n 
1 215 ARG n 
1 216 TRP n 
1 217 PHE n 
1 218 LEU n 
1 219 ASN n 
1 220 ARG n 
1 221 PHE n 
1 222 THR n 
1 223 THR n 
1 224 THR n 
1 225 LEU n 
1 226 ASN n 
1 227 ASP n 
1 228 PHE n 
1 229 ASN n 
1 230 LEU n 
1 231 VAL n 
1 232 ALA n 
1 233 MET n 
1 234 LYS n 
1 235 TYR n 
1 236 ASN n 
1 237 TYR n 
1 238 GLU n 
1 239 PRO n 
1 240 LEU n 
1 241 THR n 
1 242 GLN n 
1 243 ASP n 
1 244 HIS n 
1 245 VAL n 
1 246 ASP n 
1 247 ILE n 
1 248 LEU n 
1 249 GLY n 
1 250 PRO n 
1 251 LEU n 
1 252 SER n 
1 253 ALA n 
1 254 GLN n 
1 255 THR n 
1 256 GLY n 
1 257 ILE n 
1 258 ALA n 
1 259 VAL n 
1 260 LEU n 
1 261 ASP n 
1 262 MET n 
1 263 CYS n 
1 264 ALA n 
1 265 SER n 
1 266 LEU n 
1 267 LYS n 
1 268 GLU n 
1 269 LEU n 
1 270 LEU n 
1 271 GLN n 
1 272 ASN n 
1 273 GLY n 
1 274 MET n 
1 275 ASN n 
1 276 GLY n 
1 277 ARG n 
1 278 THR n 
1 279 ILE n 
1 280 LEU n 
1 281 GLY n 
1 282 SER n 
1 283 ALA n 
1 284 LEU n 
1 285 LEU n 
1 286 GLU n 
1 287 ASP n 
1 288 GLU n 
1 289 PHE n 
1 290 THR n 
1 291 PRO n 
1 292 PHE n 
1 293 ASP n 
1 294 VAL n 
1 295 VAL n 
1 296 ARG n 
1 297 GLN n 
1 298 CYS n 
1 299 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   299 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
X77 non-polymer         . 
'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' ? 'C27 H33 N5 O2'  
459.583 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PHE 1   3   3   PHE PHE A . n 
A 1 2   ARG 2   4   4   ARG ARG A . n 
A 1 3   LYS 3   5   5   LYS LYS A . n 
A 1 4   MET 4   6   6   MET MET A . n 
A 1 5   ALA 5   7   7   ALA ALA A . n 
A 1 6   PHE 6   8   8   PHE PHE A . n 
A 1 7   PRO 7   9   9   PRO PRO A . n 
A 1 8   SER 8   10  10  SER SER A . n 
A 1 9   GLY 9   11  11  GLY GLY A . n 
A 1 10  LYS 10  12  12  LYS LYS A . n 
A 1 11  VAL 11  13  13  VAL VAL A . n 
A 1 12  GLU 12  14  14  GLU GLU A . n 
A 1 13  GLY 13  15  15  GLY GLY A . n 
A 1 14  CYS 14  16  16  CYS CYS A . n 
A 1 15  MET 15  17  17  MET MET A . n 
A 1 16  VAL 16  18  18  VAL VAL A . n 
A 1 17  GLN 17  19  19  GLN GLN A . n 
A 1 18  VAL 18  20  20  VAL VAL A . n 
A 1 19  THR 19  21  21  THR THR A . n 
A 1 20  CYS 20  22  22  CYS CYS A . n 
A 1 21  GLY 21  23  23  GLY GLY A . n 
A 1 22  THR 22  24  24  THR THR A . n 
A 1 23  THR 23  25  25  THR THR A . n 
A 1 24  THR 24  26  26  THR THR A . n 
A 1 25  LEU 25  27  27  LEU LEU A . n 
A 1 26  ASN 26  28  28  ASN ASN A . n 
A 1 27  GLY 27  29  29  GLY GLY A . n 
A 1 28  LEU 28  30  30  LEU LEU A . n 
A 1 29  TRP 29  31  31  TRP TRP A . n 
A 1 30  LEU 30  32  32  LEU LEU A . n 
A 1 31  ASP 31  33  33  ASP ASP A . n 
A 1 32  ASP 32  34  34  ASP ASP A . n 
A 1 33  VAL 33  35  35  VAL VAL A . n 
A 1 34  VAL 34  36  36  VAL VAL A . n 
A 1 35  TYR 35  37  37  TYR TYR A . n 
A 1 36  CYS 36  38  38  CYS CYS A . n 
A 1 37  PRO 37  39  39  PRO PRO A . n 
A 1 38  ARG 38  40  40  ARG ARG A . n 
A 1 39  HIS 39  41  41  HIS HIS A . n 
A 1 40  VAL 40  42  42  VAL VAL A . n 
A 1 41  ILE 41  43  43  ILE ILE A . n 
A 1 42  CYS 42  44  44  CYS CYS A . n 
A 1 43  THR 43  45  45  THR THR A . n 
A 1 44  SER 44  46  46  SER SER A . n 
A 1 45  GLU 45  47  47  GLU GLU A . n 
A 1 46  ASP 46  48  48  ASP ASP A . n 
A 1 47  MET 47  49  49  MET MET A . n 
A 1 48  LEU 48  50  50  LEU LEU A . n 
A 1 49  ASN 49  51  51  ASN ASN A . n 
A 1 50  PRO 50  52  52  PRO PRO A . n 
A 1 51  ASN 51  53  53  ASN ASN A . n 
A 1 52  TYR 52  54  54  TYR TYR A . n 
A 1 53  GLU 53  55  55  GLU GLU A . n 
A 1 54  ASP 54  56  56  ASP ASP A . n 
A 1 55  LEU 55  57  57  LEU LEU A . n 
A 1 56  LEU 56  58  58  LEU LEU A . n 
A 1 57  ILE 57  59  59  ILE ILE A . n 
A 1 58  ARG 58  60  60  ARG ARG A . n 
A 1 59  LYS 59  61  61  LYS LYS A . n 
A 1 60  SER 60  62  62  SER SER A . n 
A 1 61  ASN 61  63  63  ASN ASN A . n 
A 1 62  HIS 62  64  64  HIS HIS A . n 
A 1 63  ASN 63  65  65  ASN ASN A . n 
A 1 64  PHE 64  66  66  PHE PHE A . n 
A 1 65  LEU 65  67  67  LEU LEU A . n 
A 1 66  VAL 66  68  68  VAL VAL A . n 
A 1 67  GLN 67  69  69  GLN GLN A . n 
A 1 68  ALA 68  70  70  ALA ALA A . n 
A 1 69  GLY 69  71  71  GLY GLY A . n 
A 1 70  ASN 70  72  72  ASN ASN A . n 
A 1 71  VAL 71  73  73  VAL VAL A . n 
A 1 72  GLN 72  74  74  GLN GLN A . n 
A 1 73  LEU 73  75  75  LEU LEU A . n 
A 1 74  ARG 74  76  76  ARG ARG A . n 
A 1 75  VAL 75  77  77  VAL VAL A . n 
A 1 76  ILE 76  78  78  ILE ILE A . n 
A 1 77  GLY 77  79  79  GLY GLY A . n 
A 1 78  HIS 78  80  80  HIS HIS A . n 
A 1 79  SER 79  81  81  SER SER A . n 
A 1 80  MET 80  82  82  MET MET A . n 
A 1 81  GLN 81  83  83  GLN GLN A . n 
A 1 82  ASN 82  84  84  ASN ASN A . n 
A 1 83  CYS 83  85  85  CYS CYS A . n 
A 1 84  VAL 84  86  86  VAL VAL A . n 
A 1 85  LEU 85  87  87  LEU LEU A . n 
A 1 86  LYS 86  88  88  LYS LYS A . n 
A 1 87  LEU 87  89  89  LEU LEU A . n 
A 1 88  LYS 88  90  90  LYS LYS A . n 
A 1 89  VAL 89  91  91  VAL VAL A . n 
A 1 90  ASP 90  92  92  ASP ASP A . n 
A 1 91  THR 91  93  93  THR THR A . n 
A 1 92  ALA 92  94  94  ALA ALA A . n 
A 1 93  ASN 93  95  95  ASN ASN A . n 
A 1 94  PRO 94  96  96  PRO PRO A . n 
A 1 95  LYS 95  97  97  LYS LYS A . n 
A 1 96  THR 96  98  98  THR THR A . n 
A 1 97  PRO 97  99  99  PRO PRO A . n 
A 1 98  LYS 98  100 100 LYS LYS A . n 
A 1 99  TYR 99  101 101 TYR TYR A . n 
A 1 100 LYS 100 102 102 LYS LYS A . n 
A 1 101 PHE 101 103 103 PHE PHE A . n 
A 1 102 VAL 102 104 104 VAL VAL A . n 
A 1 103 ARG 103 105 105 ARG ARG A . n 
A 1 104 ILE 104 106 106 ILE ILE A . n 
A 1 105 GLN 105 107 107 GLN GLN A . n 
A 1 106 PRO 106 108 108 PRO PRO A . n 
A 1 107 GLY 107 109 109 GLY GLY A . n 
A 1 108 GLN 108 110 110 GLN GLN A . n 
A 1 109 THR 109 111 111 THR THR A . n 
A 1 110 PHE 110 112 112 PHE PHE A . n 
A 1 111 SER 111 113 113 SER SER A . n 
A 1 112 VAL 112 114 114 VAL VAL A . n 
A 1 113 LEU 113 115 115 LEU LEU A . n 
A 1 114 ALA 114 116 116 ALA ALA A . n 
A 1 115 CYS 115 117 117 CYS CYS A . n 
A 1 116 TYR 116 118 118 TYR TYR A . n 
A 1 117 ASN 117 119 119 ASN ASN A . n 
A 1 118 GLY 118 120 120 GLY GLY A . n 
A 1 119 SER 119 121 121 SER SER A . n 
A 1 120 PRO 120 122 122 PRO PRO A . n 
A 1 121 SER 121 123 123 SER SER A . n 
A 1 122 GLY 122 124 124 GLY GLY A . n 
A 1 123 VAL 123 125 125 VAL VAL A . n 
A 1 124 TYR 124 126 126 TYR TYR A . n 
A 1 125 GLN 125 127 127 GLN GLN A . n 
A 1 126 CYS 126 128 128 CYS CYS A . n 
A 1 127 ALA 127 129 129 ALA ALA A . n 
A 1 128 MET 128 130 130 MET MET A . n 
A 1 129 ARG 129 131 131 ARG ARG A . n 
A 1 130 PRO 130 132 132 PRO PRO A . n 
A 1 131 ASN 131 133 133 ASN ASN A . n 
A 1 132 PHE 132 134 134 PHE PHE A . n 
A 1 133 THR 133 135 135 THR THR A . n 
A 1 134 ILE 134 136 136 ILE ILE A . n 
A 1 135 LYS 135 137 137 LYS LYS A . n 
A 1 136 GLY 136 138 138 GLY GLY A . n 
A 1 137 SER 137 139 139 SER SER A . n 
A 1 138 PHE 138 140 140 PHE PHE A . n 
A 1 139 LEU 139 141 141 LEU LEU A . n 
A 1 140 ASN 140 142 142 ASN ASN A . n 
A 1 141 GLY 141 143 143 GLY GLY A . n 
A 1 142 SER 142 144 144 SER SER A . n 
A 1 143 CYS 143 145 145 CYS CYS A . n 
A 1 144 GLY 144 146 146 GLY GLY A . n 
A 1 145 SER 145 147 147 SER SER A . n 
A 1 146 VAL 146 148 148 VAL VAL A . n 
A 1 147 GLY 147 149 149 GLY GLY A . n 
A 1 148 PHE 148 150 150 PHE PHE A . n 
A 1 149 ASN 149 151 151 ASN ASN A . n 
A 1 150 ILE 150 152 152 ILE ILE A . n 
A 1 151 ASP 151 153 153 ASP ASP A . n 
A 1 152 TYR 152 154 154 TYR TYR A . n 
A 1 153 ASP 153 155 155 ASP ASP A . n 
A 1 154 CYS 154 156 156 CYS CYS A . n 
A 1 155 VAL 155 157 157 VAL VAL A . n 
A 1 156 SER 156 158 158 SER SER A . n 
A 1 157 PHE 157 159 159 PHE PHE A . n 
A 1 158 CYS 158 160 160 CYS CYS A . n 
A 1 159 TYR 159 161 161 TYR TYR A . n 
A 1 160 MET 160 162 162 MET MET A . n 
A 1 161 HIS 161 163 163 HIS HIS A . n 
A 1 162 HIS 162 164 164 HIS HIS A . n 
A 1 163 MET 163 165 165 MET MET A . n 
A 1 164 GLU 164 166 166 GLU GLU A . n 
A 1 165 LEU 165 167 167 LEU LEU A . n 
A 1 166 PRO 166 168 168 PRO PRO A . n 
A 1 167 THR 167 169 169 THR THR A . n 
A 1 168 GLY 168 170 170 GLY GLY A . n 
A 1 169 VAL 169 171 171 VAL VAL A . n 
A 1 170 HIS 170 172 172 HIS HIS A . n 
A 1 171 ALA 171 173 173 ALA ALA A . n 
A 1 172 GLY 172 174 174 GLY GLY A . n 
A 1 173 THR 173 175 175 THR THR A . n 
A 1 174 ASP 174 176 176 ASP ASP A . n 
A 1 175 LEU 175 177 177 LEU LEU A . n 
A 1 176 GLU 176 178 178 GLU GLU A . n 
A 1 177 GLY 177 179 179 GLY GLY A . n 
A 1 178 ASN 178 180 180 ASN ASN A . n 
A 1 179 PHE 179 181 181 PHE PHE A . n 
A 1 180 TYR 180 182 182 TYR TYR A . n 
A 1 181 GLY 181 183 183 GLY GLY A . n 
A 1 182 PRO 182 184 184 PRO PRO A . n 
A 1 183 PHE 183 185 185 PHE PHE A . n 
A 1 184 PHE 184 186 186 PHE PHE A . n 
A 1 185 ASP 185 187 187 ASP ASP A . n 
A 1 186 ARG 186 188 188 ARG ARG A . n 
A 1 187 GLN 187 189 189 GLN GLN A . n 
A 1 188 THR 188 190 190 THR THR A . n 
A 1 189 ALA 189 191 191 ALA ALA A . n 
A 1 190 GLN 190 192 192 GLN GLN A . n 
A 1 191 ALA 191 193 193 ALA ALA A . n 
A 1 192 ALA 192 194 194 ALA ALA A . n 
A 1 193 GLY 193 195 195 GLY GLY A . n 
A 1 194 THR 194 196 196 THR THR A . n 
A 1 195 ASP 195 197 197 ASP ASP A . n 
A 1 196 THR 196 198 198 THR THR A . n 
A 1 197 THR 197 199 199 THR THR A . n 
A 1 198 ILE 198 200 200 ILE ILE A . n 
A 1 199 THR 199 201 201 THR THR A . n 
A 1 200 VAL 200 202 202 VAL VAL A . n 
A 1 201 ASN 201 203 203 ASN ASN A . n 
A 1 202 VAL 202 204 204 VAL VAL A . n 
A 1 203 LEU 203 205 205 LEU LEU A . n 
A 1 204 ALA 204 206 206 ALA ALA A . n 
A 1 205 TRP 205 207 207 TRP TRP A . n 
A 1 206 LEU 206 208 208 LEU LEU A . n 
A 1 207 TYR 207 209 209 TYR TYR A . n 
A 1 208 ALA 208 210 210 ALA ALA A . n 
A 1 209 ALA 209 211 211 ALA ALA A . n 
A 1 210 VAL 210 212 212 VAL VAL A . n 
A 1 211 ILE 211 213 213 ILE ILE A . n 
A 1 212 ASN 212 214 214 ASN ASN A . n 
A 1 213 GLY 213 215 215 GLY GLY A . n 
A 1 214 ASP 214 216 216 ASP ASP A . n 
A 1 215 ARG 215 217 217 ARG ARG A . n 
A 1 216 TRP 216 218 218 TRP TRP A . n 
A 1 217 PHE 217 219 219 PHE PHE A . n 
A 1 218 LEU 218 220 220 LEU LEU A . n 
A 1 219 ASN 219 221 221 ASN ASN A . n 
A 1 220 ARG 220 222 222 ARG ARG A . n 
A 1 221 PHE 221 223 223 PHE PHE A . n 
A 1 222 THR 222 224 224 THR THR A . n 
A 1 223 THR 223 225 225 THR THR A . n 
A 1 224 THR 224 226 226 THR THR A . n 
A 1 225 LEU 225 227 227 LEU LEU A . n 
A 1 226 ASN 226 228 228 ASN ASN A . n 
A 1 227 ASP 227 229 229 ASP ASP A . n 
A 1 228 PHE 228 230 230 PHE PHE A . n 
A 1 229 ASN 229 231 231 ASN ASN A . n 
A 1 230 LEU 230 232 232 LEU LEU A . n 
A 1 231 VAL 231 233 233 VAL VAL A . n 
A 1 232 ALA 232 234 234 ALA ALA A . n 
A 1 233 MET 233 235 235 MET MET A . n 
A 1 234 LYS 234 236 236 LYS LYS A . n 
A 1 235 TYR 235 237 237 TYR TYR A . n 
A 1 236 ASN 236 238 238 ASN ASN A . n 
A 1 237 TYR 237 239 239 TYR TYR A . n 
A 1 238 GLU 238 240 240 GLU GLU A . n 
A 1 239 PRO 239 241 241 PRO PRO A . n 
A 1 240 LEU 240 242 242 LEU LEU A . n 
A 1 241 THR 241 243 243 THR THR A . n 
A 1 242 GLN 242 244 244 GLN GLN A . n 
A 1 243 ASP 243 245 245 ASP ASP A . n 
A 1 244 HIS 244 246 246 HIS HIS A . n 
A 1 245 VAL 245 247 247 VAL VAL A . n 
A 1 246 ASP 246 248 248 ASP ASP A . n 
A 1 247 ILE 247 249 249 ILE ILE A . n 
A 1 248 LEU 248 250 250 LEU LEU A . n 
A 1 249 GLY 249 251 251 GLY GLY A . n 
A 1 250 PRO 250 252 252 PRO PRO A . n 
A 1 251 LEU 251 253 253 LEU LEU A . n 
A 1 252 SER 252 254 254 SER SER A . n 
A 1 253 ALA 253 255 255 ALA ALA A . n 
A 1 254 GLN 254 256 256 GLN GLN A . n 
A 1 255 THR 255 257 257 THR THR A . n 
A 1 256 GLY 256 258 258 GLY GLY A . n 
A 1 257 ILE 257 259 259 ILE ILE A . n 
A 1 258 ALA 258 260 260 ALA ALA A . n 
A 1 259 VAL 259 261 261 VAL VAL A . n 
A 1 260 LEU 260 262 262 LEU LEU A . n 
A 1 261 ASP 261 263 263 ASP ASP A . n 
A 1 262 MET 262 264 264 MET MET A . n 
A 1 263 CYS 263 265 265 CYS CYS A . n 
A 1 264 ALA 264 266 266 ALA ALA A . n 
A 1 265 SER 265 267 267 SER SER A . n 
A 1 266 LEU 266 268 268 LEU LEU A . n 
A 1 267 LYS 267 269 269 LYS LYS A . n 
A 1 268 GLU 268 270 270 GLU GLU A . n 
A 1 269 LEU 269 271 271 LEU LEU A . n 
A 1 270 LEU 270 272 272 LEU LEU A . n 
A 1 271 GLN 271 273 273 GLN GLN A . n 
A 1 272 ASN 272 274 274 ASN ASN A . n 
A 1 273 GLY 273 275 275 GLY GLY A . n 
A 1 274 MET 274 276 276 MET MET A . n 
A 1 275 ASN 275 277 277 ASN ASN A . n 
A 1 276 GLY 276 278 278 GLY GLY A . n 
A 1 277 ARG 277 279 279 ARG ARG A . n 
A 1 278 THR 278 280 280 THR THR A . n 
A 1 279 ILE 279 281 281 ILE ILE A . n 
A 1 280 LEU 280 282 282 LEU LEU A . n 
A 1 281 GLY 281 283 283 GLY GLY A . n 
A 1 282 SER 282 284 284 SER SER A . n 
A 1 283 ALA 283 285 285 ALA ALA A . n 
A 1 284 LEU 284 286 286 LEU LEU A . n 
A 1 285 LEU 285 287 287 LEU LEU A . n 
A 1 286 GLU 286 288 288 GLU GLU A . n 
A 1 287 ASP 287 289 289 ASP ASP A . n 
A 1 288 GLU 288 290 290 GLU GLU A . n 
A 1 289 PHE 289 291 291 PHE PHE A . n 
A 1 290 THR 290 292 292 THR THR A . n 
A 1 291 PRO 291 293 293 PRO PRO A . n 
A 1 292 PHE 292 294 294 PHE PHE A . n 
A 1 293 ASP 293 295 295 ASP ASP A . n 
A 1 294 VAL 294 296 296 VAL VAL A . n 
A 1 295 VAL 295 297 297 VAL VAL A . n 
A 1 296 ARG 296 298 298 ARG ARG A . n 
A 1 297 GLN 297 299 299 GLN GLN A . n 
A 1 298 CYS 298 300 300 CYS CYS A . n 
A 1 299 SER 299 301 301 SER SER A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X77 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X77 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 X77 1  401 1  X77 LIG A . 
C 3 HOH 1  501 19 HOH HOH A . 
C 3 HOH 2  502 6  HOH HOH A . 
C 3 HOH 3  503 24 HOH HOH A . 
C 3 HOH 4  504 45 HOH HOH A . 
C 3 HOH 5  505 17 HOH HOH A . 
C 3 HOH 6  506 51 HOH HOH A . 
C 3 HOH 7  507 4  HOH HOH A . 
C 3 HOH 8  508 47 HOH HOH A . 
C 3 HOH 9  509 26 HOH HOH A . 
C 3 HOH 10 510 25 HOH HOH A . 
C 3 HOH 11 511 5  HOH HOH A . 
C 3 HOH 12 512 29 HOH HOH A . 
C 3 HOH 13 513 33 HOH HOH A . 
C 3 HOH 14 514 39 HOH HOH A . 
C 3 HOH 15 515 10 HOH HOH A . 
C 3 HOH 16 516 15 HOH HOH A . 
C 3 HOH 17 517 23 HOH HOH A . 
C 3 HOH 18 518 30 HOH HOH A . 
C 3 HOH 19 519 36 HOH HOH A . 
C 3 HOH 20 520 2  HOH HOH A . 
C 3 HOH 21 521 41 HOH HOH A . 
C 3 HOH 22 522 1  HOH HOH A . 
C 3 HOH 23 523 43 HOH HOH A . 
C 3 HOH 24 524 48 HOH HOH A . 
C 3 HOH 25 525 49 HOH HOH A . 
C 3 HOH 26 526 14 HOH HOH A . 
C 3 HOH 27 527 50 HOH HOH A . 
C 3 HOH 28 528 31 HOH HOH A . 
C 3 HOH 29 529 12 HOH HOH A . 
C 3 HOH 30 530 8  HOH HOH A . 
C 3 HOH 31 531 7  HOH HOH A . 
C 3 HOH 32 532 37 HOH HOH A . 
C 3 HOH 33 533 16 HOH HOH A . 
C 3 HOH 34 534 18 HOH HOH A . 
C 3 HOH 35 535 3  HOH HOH A . 
C 3 HOH 36 536 46 HOH HOH A . 
C 3 HOH 37 537 32 HOH HOH A . 
C 3 HOH 38 538 44 HOH HOH A . 
C 3 HOH 39 539 38 HOH HOH A . 
C 3 HOH 40 540 11 HOH HOH A . 
C 3 HOH 41 541 42 HOH HOH A . 
C 3 HOH 42 542 34 HOH HOH A . 
C 3 HOH 43 543 20 HOH HOH A . 
C 3 HOH 44 544 28 HOH HOH A . 
C 3 HOH 45 545 22 HOH HOH A . 
C 3 HOH 46 546 13 HOH HOH A . 
C 3 HOH 47 547 35 HOH HOH A . 
C 3 HOH 48 548 40 HOH HOH A . 
C 3 HOH 49 549 9  HOH HOH A . 
C 3 HOH 50 550 21 HOH HOH A . 
C 3 HOH 51 551 27 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.12_2829 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   100.417 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YKQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     113.520 
_cell.length_a_esd                 ? 
_cell.length_b                     55.000 
_cell.length_b_esd                 ? 
_cell.length_c                     45.480 
_cell.length_c_esd                 ? 
_cell.volume                       279278.679 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YKQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YKQ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.10 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.52 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M Na2SO4, 20%PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          33.7487825992 
_reflns.entry_id                                       8YKQ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               55.82 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     18632 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.163 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.05 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1371 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.11 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               38.3851127617 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YKQ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             55.82 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     18627 
_refine.ls_number_reflns_R_free                  963 
_refine.ls_number_reflns_R_work                  17664 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.1377933897 
_refine.ls_percent_reflns_R_free                 5.16991464004 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.189681002424 
_refine.ls_R_factor_R_free                       0.233241740718 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.187468294814 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36160804664 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.3598627277 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.237556930726 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        55.82 
_refine_hist.number_atoms_solvent             51 
_refine_hist.number_atoms_total               2408 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2323 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00743292077151 ? 2413 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.962961046859   ? 3281 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0504809559926  ? 365  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00579803372848 ? 425  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 11.5470412153    ? 1407 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.0    2.1055 . . 172 2472 99.0262172285 . . . . 0.255486995759 . . . . . . . . . . . 0.332887736308 
'X-RAY DIFFRACTION' 2.1055 2.2374 . . 124 2505 99.0580256217 . . . . 0.229591176808 . . . . . . . . . . . 0.253973068238 
'X-RAY DIFFRACTION' 2.2374 2.4101 . . 136 2512 99.3993993994 . . . . 0.213066805472 . . . . . . . . . . . 0.290587331066 
'X-RAY DIFFRACTION' 2.4101 2.6527 . . 140 2533 99.4789728322 . . . . 0.211707408028 . . . . . . . . . . . 0.253338408017 
'X-RAY DIFFRACTION' 2.6527 3.0365 . . 150 2518 99.5893990295 . . . . 0.2044014922   . . . . . . . . . . . 0.287824216503 
'X-RAY DIFFRACTION' 3.0365 3.8255 . . 137 2522 99.1794106677 . . . . 0.180223387964 . . . . . . . . . . . 0.218145205352 
'X-RAY DIFFRACTION' 3.8255 55.82  . . 104 2602 98.25708061   . . . . 0.159915588843 . . . . . . . . . . . 0.171315100242 
# 
_struct.entry_id                     8YKQ 
_struct.title                        'Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with X77' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YKQ 
_struct_keywords.text            'VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS
;
_struct_ref.pdbx_align_begin           3266 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YKQ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 299 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC1 
_struct_ref_seq.db_align_beg                  3266 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3564 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       3 
_struct_ref_seq.pdbx_auth_seq_align_end       301 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8YKQ 
_struct_ref_seq_dif.mon_id                       PHE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      184 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTC1 
_struct_ref_seq_dif.db_mon_id                    VAL 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3449 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            186 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2160  ? 
1 MORE         -9    ? 
1 'SSA (A^2)'  25300 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_557 -x,y,-z+2 -1.0000000000 0.0000000000 0.0000000000 -16.4465657248 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 89.4607851288 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 8   ? GLY A 13  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 39  ? CYS A 42  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 51  ? LYS A 59  ? ASN A 53  LYS A 61  1 ? 9  
HELX_P HELX_P4  AA4 SER A 60  ? PHE A 64  ? SER A 62  PHE A 66  5 ? 5  
HELX_P HELX_P5  AA5 ILE A 198 ? ASN A 212 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 224 ? MET A 233 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P7  AA7 LYS A 234 ? ASN A 236 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P8  AA8 THR A 241 ? LEU A 248 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 248 ? GLY A 256 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 258 ? GLY A 273 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 290 ? SER A 299 ? THR A 292 SER A 301 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 71  ? LEU A 73  ? VAL A 73  LEU A 75  
AA1 2 LEU A 65  ? ALA A 68  ? LEU A 67  ALA A 70  
AA1 3 MET A 15  ? CYS A 20  ? MET A 17  CYS A 22  
AA1 4 THR A 23  ? LEU A 30  ? THR A 25  LEU A 32  
AA1 5 VAL A 33  ? PRO A 37  ? VAL A 35  PRO A 39  
AA1 6 VAL A 84  ? VAL A 89  ? VAL A 86  VAL A 91  
AA1 7 VAL A 75  ? GLN A 81  ? VAL A 77  GLN A 83  
AA2 1 TYR A 99  ? PHE A 101 ? TYR A 101 PHE A 103 
AA2 2 CYS A 154 ? GLU A 164 ? CYS A 156 GLU A 166 
AA2 3 VAL A 146 ? ASP A 151 ? VAL A 148 ASP A 153 
AA2 4 THR A 109 ? TYR A 116 ? THR A 111 TYR A 118 
AA2 5 SER A 119 ? ALA A 127 ? SER A 121 ALA A 129 
AA3 1 TYR A 99  ? PHE A 101 ? TYR A 101 PHE A 103 
AA3 2 CYS A 154 ? GLU A 164 ? CYS A 156 GLU A 166 
AA3 3 HIS A 170 ? THR A 173 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 71  ? O VAL A 73  N ALA A 68  ? N ALA A 70  
AA1 2 3 O LEU A 65  ? O LEU A 67  N THR A 19  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 20  O LEU A 25  ? O LEU A 27  
AA1 4 5 N LEU A 28  ? N LEU A 30  O TYR A 35  ? O TYR A 37  
AA1 5 6 N CYS A 36  ? N CYS A 38  O LEU A 85  ? O LEU A 87  
AA1 6 7 O LYS A 86  ? O LYS A 88  N SER A 79  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 102 O PHE A 157 ? O PHE A 159 
AA2 2 3 O SER A 156 ? O SER A 158 N ASN A 149 ? N ASN A 151 
AA2 3 4 O PHE A 148 ? O PHE A 150 N SER A 111 ? N SER A 113 
AA2 4 5 N VAL A 112 ? N VAL A 114 O TYR A 124 ? O TYR A 126 
AA3 1 2 N LYS A 100 ? N LYS A 102 O PHE A 157 ? O PHE A 159 
AA3 2 3 N MET A 163 ? N MET A 165 O ALA A 171 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   8YKQ 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A LEU 75  ? ? O A HOH 501 ? ? 1.87 
2 1 OD1 A ASP 197 ? ? O A HOH 502 ? ? 1.95 
3 1 O   A PHE 219 ? ? O A HOH 503 ? ? 1.96 
4 1 OE1 A GLU 270 ? ? O A HOH 503 ? ? 1.96 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    NH2 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    ARG 
_pdbx_validate_symm_contact.auth_seq_id_1     222 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     501 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_564 
_pdbx_validate_symm_contact.dist              1.93 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 50.67 -129.01 
2 1 ASN A 84  ? ? 50.13 -119.67 
3 1 TYR A 154 ? ? 59.97 -115.33 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     546 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   C 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
X77 C02  C N N 391 
X77 C04  C N R 392 
X77 C05  C N N 393 
X77 C07  C N N 394 
X77 C08  C N N 395 
X77 C09  C N N 396 
X77 C10  C N N 397 
X77 C11  C N N 398 
X77 C12  C N N 399 
X77 C14  C Y N 400 
X77 C15  C Y N 401 
X77 C16  C Y N 402 
X77 C17  C Y N 403 
X77 C19  C Y N 404 
X77 C20  C Y N 405 
X77 C21  C Y N 406 
X77 C22  C Y N 407 
X77 C23  C Y N 408 
X77 C24  C N N 409 
X77 C25  C N N 410 
X77 C26  C N N 411 
X77 C27  C N N 412 
X77 C28  C Y N 413 
X77 C29  C Y N 414 
X77 C30  C Y N 415 
X77 C31  C Y N 416 
X77 C33  C Y N 417 
X77 N03  N N N 418 
X77 N06  N N N 419 
X77 N18  N Y N 420 
X77 N32  N Y N 421 
X77 N34  N Y N 422 
X77 O01  O N N 423 
X77 O13  O N N 424 
X77 H041 H N N 425 
X77 H071 H N N 426 
X77 H081 H N N 427 
X77 H082 H N N 428 
X77 H091 H N N 429 
X77 H092 H N N 430 
X77 H101 H N N 431 
X77 H102 H N N 432 
X77 H112 H N N 433 
X77 H111 H N N 434 
X77 H121 H N N 435 
X77 H122 H N N 436 
X77 H151 H N N 437 
X77 H161 H N N 438 
X77 H171 H N N 439 
X77 H191 H N N 440 
X77 H211 H N N 441 
X77 H221 H N N 442 
X77 H251 H N N 443 
X77 H252 H N N 444 
X77 H253 H N N 445 
X77 H261 H N N 446 
X77 H263 H N N 447 
X77 H262 H N N 448 
X77 H272 H N N 449 
X77 H273 H N N 450 
X77 H271 H N N 451 
X77 H281 H N N 452 
X77 H291 H N N 453 
X77 H311 H N N 454 
X77 H331 H N N 455 
X77 H061 H N N 456 
X77 H1   H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
X77 C33 N32  sing Y N 376 
X77 C33 N34  doub Y N 377 
X77 N32 C31  sing Y N 378 
X77 N34 C30  sing Y N 379 
X77 C31 C30  doub Y N 380 
X77 C30 C02  sing N N 381 
X77 C27 C24  sing N N 382 
X77 C02 O01  doub N N 383 
X77 C02 N03  sing N N 384 
X77 C26 C24  sing N N 385 
X77 C28 C29  doub Y N 386 
X77 C28 C23  sing Y N 387 
X77 C24 C23  sing N N 388 
X77 C24 C25  sing N N 389 
X77 C29 C20  sing Y N 390 
X77 C23 C22  doub Y N 391 
X77 C20 N03  sing N N 392 
X77 C20 C21  doub Y N 393 
X77 C22 C21  sing Y N 394 
X77 N03 C04  sing N N 395 
X77 C19 N18  doub Y N 396 
X77 C19 C14  sing Y N 397 
X77 C04 C14  sing N N 398 
X77 C04 C05  sing N N 399 
X77 N18 C17  sing Y N 400 
X77 C14 C15  doub Y N 401 
X77 O13 C05  doub N N 402 
X77 C17 C16  doub Y N 403 
X77 C05 N06  sing N N 404 
X77 C15 C16  sing Y N 405 
X77 N06 C07  sing N N 406 
X77 C12 C07  sing N N 407 
X77 C12 C11  sing N N 408 
X77 C07 C08  sing N N 409 
X77 C11 C10  sing N N 410 
X77 C08 C09  sing N N 411 
X77 C10 C09  sing N N 412 
X77 C04 H041 sing N N 413 
X77 C07 H071 sing N N 414 
X77 C08 H081 sing N N 415 
X77 C08 H082 sing N N 416 
X77 C09 H091 sing N N 417 
X77 C09 H092 sing N N 418 
X77 C10 H101 sing N N 419 
X77 C10 H102 sing N N 420 
X77 C11 H112 sing N N 421 
X77 C11 H111 sing N N 422 
X77 C12 H121 sing N N 423 
X77 C12 H122 sing N N 424 
X77 C15 H151 sing N N 425 
X77 C16 H161 sing N N 426 
X77 C17 H171 sing N N 427 
X77 C19 H191 sing N N 428 
X77 C21 H211 sing N N 429 
X77 C22 H221 sing N N 430 
X77 C25 H251 sing N N 431 
X77 C25 H252 sing N N 432 
X77 C25 H253 sing N N 433 
X77 C26 H261 sing N N 434 
X77 C26 H263 sing N N 435 
X77 C26 H262 sing N N 436 
X77 C27 H272 sing N N 437 
X77 C27 H273 sing N N 438 
X77 C27 H271 sing N N 439 
X77 C28 H281 sing N N 440 
X77 C29 H291 sing N N 441 
X77 C31 H311 sing N N 442 
X77 C33 H331 sing N N 443 
X77 N06 H061 sing N N 444 
X77 N32 H1   sing N N 445 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8HVO 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YKQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008809 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001619 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018182 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022356 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 1   ? -9.58286  7.68312   35.27674 1.000 41.94703 ? 3   PHE A N   1 
ATOM   2    C CA  . PHE A 1 1   ? -8.26239  7.15443   35.61673 1.000 43.90183 ? 3   PHE A CA  1 
ATOM   3    C C   . PHE A 1 1   ? -8.10553  7.01928   37.13930 1.000 46.43851 ? 3   PHE A C   1 
ATOM   4    O O   . PHE A 1 1   ? -8.11845  8.01349   37.86862 1.000 51.29394 ? 3   PHE A O   1 
ATOM   5    C CB  . PHE A 1 1   ? -7.16937  8.05397   35.03539 1.000 44.87968 ? 3   PHE A CB  1 
ATOM   6    C CG  . PHE A 1 1   ? -5.77877  7.51966   35.22723 1.000 43.78129 ? 3   PHE A CG  1 
ATOM   7    C CD1 . PHE A 1 1   ? -5.21139  6.66874   34.29002 1.000 41.78194 ? 3   PHE A CD1 1 
ATOM   8    C CD2 . PHE A 1 1   ? -5.03056  7.88807   36.33893 1.000 41.23304 ? 3   PHE A CD2 1 
ATOM   9    C CE1 . PHE A 1 1   ? -3.92744  6.18028   34.46537 1.000 38.94592 ? 3   PHE A CE1 1 
ATOM   10   C CE2 . PHE A 1 1   ? -3.74880  7.40758   36.51801 1.000 41.04902 ? 3   PHE A CE2 1 
ATOM   11   C CZ  . PHE A 1 1   ? -3.19892  6.54603   35.58511 1.000 40.61738 ? 3   PHE A CZ  1 
ATOM   12   N N   . ARG A 1 2   ? -7.93583  5.78574   37.60692 1.000 42.48170 ? 4   ARG A N   1 
ATOM   13   C CA  . ARG A 1 2   ? -8.10978  5.42971   39.00659 1.000 42.42377 ? 4   ARG A CA  1 
ATOM   14   C C   . ARG A 1 2   ? -6.85280  4.78783   39.57571 1.000 38.88784 ? 4   ARG A C   1 
ATOM   15   O O   . ARG A 1 2   ? -6.04759  4.19500   38.85566 1.000 36.25433 ? 4   ARG A O   1 
ATOM   16   C CB  . ARG A 1 2   ? -9.27427  4.43587   39.18692 1.000 40.68622 ? 4   ARG A CB  1 
ATOM   17   C CG  . ARG A 1 2   ? -10.60676 4.93688   38.69261 1.000 46.57820 ? 4   ARG A CG  1 
ATOM   18   C CD  . ARG A 1 2   ? -11.74572 4.01583   39.08053 1.000 40.24386 ? 4   ARG A CD  1 
ATOM   19   N NE  . ARG A 1 2   ? -13.03637 4.69210   38.92608 1.000 41.34127 ? 4   ARG A NE  1 
ATOM   20   C CZ  . ARG A 1 2   ? -13.67730 5.29033   39.92893 1.000 44.98432 ? 4   ARG A CZ  1 
ATOM   21   N NH1 . ARG A 1 2   ? -13.14792 5.27643   41.14940 1.000 48.85805 ? 4   ARG A NH1 1 
ATOM   22   N NH2 . ARG A 1 2   ? -14.84330 5.90667   39.72258 1.000 42.10846 ? 4   ARG A NH2 1 
ATOM   23   N N   . LYS A 1 3   ? -6.71733  4.88564   40.89847 1.000 37.06189 ? 5   LYS A N   1 
ATOM   24   C CA  . LYS A 1 3   ? -5.82624  4.00027   41.63834 1.000 42.20006 ? 5   LYS A CA  1 
ATOM   25   C C   . LYS A 1 3   ? -6.28086  2.54435   41.46653 1.000 39.06247 ? 5   LYS A C   1 
ATOM   26   O O   . LYS A 1 3   ? -7.36715  2.16681   41.91963 1.000 44.37322 ? 5   LYS A O   1 
ATOM   27   C CB  . LYS A 1 3   ? -5.81454  4.40142   43.11412 1.000 44.74743 ? 5   LYS A CB  1 
ATOM   28   C CG  . LYS A 1 3   ? -4.48348  4.21980   43.80517 1.000 47.45042 ? 5   LYS A CG  1 
ATOM   29   C CD  . LYS A 1 3   ? -3.43393  5.14401   43.23910 1.000 44.97064 ? 5   LYS A CD  1 
ATOM   30   C CE  . LYS A 1 3   ? -3.75885  6.60245   43.51715 1.000 45.23096 ? 5   LYS A CE  1 
ATOM   31   N NZ  . LYS A 1 3   ? -3.36043  7.05938   44.86639 1.000 47.10943 ? 5   LYS A NZ  1 
ATOM   32   N N   . MET A 1 4   ? -5.47320  1.71705   40.81259 1.000 35.27946 ? 6   MET A N   1 
ATOM   33   C CA  . MET A 1 4   ? -5.83632  0.33980   40.49578 1.000 36.28635 ? 6   MET A CA  1 
ATOM   34   C C   . MET A 1 4   ? -4.87391  -0.61855  41.18035 1.000 32.88338 ? 6   MET A C   1 
ATOM   35   O O   . MET A 1 4   ? -3.65664  -0.47003  41.05683 1.000 33.70057 ? 6   MET A O   1 
ATOM   36   C CB  . MET A 1 4   ? -5.80687  0.12030   38.98917 1.000 34.87974 ? 6   MET A CB  1 
ATOM   37   C CG  . MET A 1 4   ? -6.45638  -1.15405  38.52553 1.000 40.86809 ? 6   MET A CG  1 
ATOM   38   S SD  . MET A 1 4   ? -7.01571  -0.96119  36.81476 1.000 54.93425 ? 6   MET A SD  1 
ATOM   39   C CE  . MET A 1 4   ? -7.56810  0.74107   36.84512 1.000 39.09550 ? 6   MET A CE  1 
ATOM   40   N N   . ALA A 1 5   ? -5.41561  -1.59955  41.88452 1.000 31.29528 ? 7   ALA A N   1 
ATOM   41   C CA  . ALA A 1 5   ? -4.60570  -2.60319  42.55818 1.000 31.35118 ? 7   ALA A CA  1 
ATOM   42   C C   . ALA A 1 5   ? -4.54222  -3.87786  41.72960 1.000 33.24366 ? 7   ALA A C   1 
ATOM   43   O O   . ALA A 1 5   ? -5.39090  -4.12133  40.87133 1.000 31.40770 ? 7   ALA A O   1 
ATOM   44   C CB  . ALA A 1 5   ? -5.17457  -2.92769  43.93660 1.000 27.71285 ? 7   ALA A CB  1 
ATOM   45   N N   . PHE A 1 6   ? -3.53941  -4.70965  42.02465 1.000 32.58578 ? 8   PHE A N   1 
ATOM   46   C CA  . PHE A 1 6   ? -3.46466  -6.03342  41.41010 1.000 32.53806 ? 8   PHE A CA  1 
ATOM   47   C C   . PHE A 1 6   ? -4.55059  -6.94081  41.97670 1.000 30.95266 ? 8   PHE A C   1 
ATOM   48   O O   . PHE A 1 6   ? -4.91944  -6.82360  43.15227 1.000 30.16836 ? 8   PHE A O   1 
ATOM   49   C CB  . PHE A 1 6   ? -2.10551  -6.68507  41.65886 1.000 32.93585 ? 8   PHE A CB  1 
ATOM   50   C CG  . PHE A 1 6   ? -0.99698  -6.12715  40.81931 1.000 34.98666 ? 8   PHE A CG  1 
ATOM   51   C CD1 . PHE A 1 6   ? -0.90212  -6.43527  39.46937 1.000 38.00088 ? 8   PHE A CD1 1 
ATOM   52   C CD2 . PHE A 1 6   ? -0.04738  -5.29255  41.38339 1.000 33.45159 ? 8   PHE A CD2 1 
ATOM   53   C CE1 . PHE A 1 6   ? 0.12742   -5.91779  38.69781 1.000 40.75643 ? 8   PHE A CE1 1 
ATOM   54   C CE2 . PHE A 1 6   ? 0.97957   -4.76905  40.61625 1.000 39.07286 ? 8   PHE A CE2 1 
ATOM   55   C CZ  . PHE A 1 6   ? 1.06815   -5.08570  39.27154 1.000 41.36647 ? 8   PHE A CZ  1 
ATOM   56   N N   . PRO A 1 7   ? -5.06519  -7.87216  41.16939 1.000 32.46310 ? 9   PRO A N   1 
ATOM   57   C CA  . PRO A 1 7   ? -5.97115  -8.87798  41.71646 1.000 28.44535 ? 9   PRO A CA  1 
ATOM   58   C C   . PRO A 1 7   ? -5.28400  -9.59845  42.87418 1.000 31.19444 ? 9   PRO A C   1 
ATOM   59   O O   . PRO A 1 7   ? -4.07844  -9.85232  42.85048 1.000 32.48579 ? 9   PRO A O   1 
ATOM   60   C CB  . PRO A 1 7   ? -6.23585  -9.81731  40.52545 1.000 34.27253 ? 9   PRO A CB  1 
ATOM   61   C CG  . PRO A 1 7   ? -5.70109  -9.10698  39.31524 1.000 32.02717 ? 9   PRO A CG  1 
ATOM   62   C CD  . PRO A 1 7   ? -4.62898  -8.20763  39.80172 1.000 34.73083 ? 9   PRO A CD  1 
ATOM   63   N N   . SER A 1 8   ? -6.05132  -9.89429  43.90607 1.000 26.05931 ? 10  SER A N   1 
ATOM   64   C CA  . SER A 1 8   ? -5.46738  -10.27908 45.18309 1.000 30.69165 ? 10  SER A CA  1 
ATOM   65   C C   . SER A 1 8   ? -5.58510  -11.77101 45.48309 1.000 32.79375 ? 10  SER A C   1 
ATOM   66   O O   . SER A 1 8   ? -5.15591  -12.20642 46.55804 1.000 31.40969 ? 10  SER A O   1 
ATOM   67   C CB  . SER A 1 8   ? -6.12525  -9.48039  46.31078 1.000 32.09787 ? 10  SER A CB  1 
ATOM   68   O OG  . SER A 1 8   ? -7.51711  -9.78845  46.38552 1.000 35.93972 ? 10  SER A OG  1 
ATOM   69   N N   . GLY A 1 9   ? -6.13922  -12.56236 44.56215 1.000 31.75618 ? 11  GLY A N   1 
ATOM   70   C CA  . GLY A 1 9   ? -6.47309  -13.94107 44.89094 1.000 29.82895 ? 11  GLY A CA  1 
ATOM   71   C C   . GLY A 1 9   ? -5.27585  -14.74127 45.35687 1.000 30.83165 ? 11  GLY A C   1 
ATOM   72   O O   . GLY A 1 9   ? -5.35494  -15.48781 46.33818 1.000 33.60502 ? 11  GLY A O   1 
ATOM   73   N N   . LYS A 1 10  ? -4.14799  -14.59880 44.65954 1.000 30.21301 ? 12  LYS A N   1 
ATOM   74   C CA  . LYS A 1 10  ? -2.96786  -15.38140 45.01169 1.000 33.71183 ? 12  LYS A CA  1 
ATOM   75   C C   . LYS A 1 10  ? -2.50218  -15.09976 46.42902 1.000 34.90007 ? 12  LYS A C   1 
ATOM   76   O O   . LYS A 1 10  ? -1.91603  -15.98090 47.07361 1.000 35.99410 ? 12  LYS A O   1 
ATOM   77   C CB  . LYS A 1 10  ? -1.84261  -15.10672 44.01587 1.000 36.77847 ? 12  LYS A CB  1 
ATOM   78   C CG  . LYS A 1 10  ? -2.10948  -15.69354 42.63837 1.000 38.66388 ? 12  LYS A CG  1 
ATOM   79   C CD  . LYS A 1 10  ? -0.92877  -15.50395 41.70943 1.000 43.97853 ? 12  LYS A CD  1 
ATOM   80   C CE  . LYS A 1 10  ? -1.36428  -15.67837 40.26197 1.000 52.79709 ? 12  LYS A CE  1 
ATOM   81   N NZ  . LYS A 1 10  ? -2.28227  -16.85219 40.08674 1.000 56.57675 ? 12  LYS A NZ  1 
ATOM   82   N N   . VAL A 1 11  ? -2.76509  -13.89323 46.93485 1.000 28.04454 ? 13  VAL A N   1 
ATOM   83   C CA  . VAL A 1 11  ? -2.30877  -13.52519 48.27023 1.000 32.13226 ? 13  VAL A CA  1 
ATOM   84   C C   . VAL A 1 11  ? -3.32117  -13.96995 49.31459 1.000 32.45732 ? 13  VAL A C   1 
ATOM   85   O O   . VAL A 1 11  ? -2.94509  -14.38256 50.42203 1.000 31.07485 ? 13  VAL A O   1 
ATOM   86   C CB  . VAL A 1 11  ? -2.02885  -12.01080 48.34865 1.000 28.98629 ? 13  VAL A CB  1 
ATOM   87   C CG1 . VAL A 1 11  ? -1.44708  -11.63232 49.72650 1.000 32.23774 ? 13  VAL A CG1 1 
ATOM   88   C CG2 . VAL A 1 11  ? -1.07047  -11.60236 47.25195 1.000 30.80118 ? 13  VAL A CG2 1 
ATOM   89   N N   . GLU A 1 12  ? -4.61462  -13.92931 48.96718 1.000 30.51313 ? 14  GLU A N   1 
ATOM   90   C CA  . GLU A 1 12  ? -5.66600  -14.25602 49.93725 1.000 33.59741 ? 14  GLU A CA  1 
ATOM   91   C C   . GLU A 1 12  ? -5.49907  -15.65963 50.52726 1.000 33.62484 ? 14  GLU A C   1 
ATOM   92   O O   . GLU A 1 12  ? -5.80369  -15.88728 51.70658 1.000 31.55018 ? 14  GLU A O   1 
ATOM   93   C CB  . GLU A 1 12  ? -7.03981  -14.14599 49.28384 1.000 32.65641 ? 14  GLU A CB  1 
ATOM   94   C CG  . GLU A 1 12  ? -7.48989  -12.72592 48.94619 1.000 30.78650 ? 14  GLU A CG  1 
ATOM   95   C CD  . GLU A 1 12  ? -8.68864  -12.74913 48.01895 1.000 35.18253 ? 14  GLU A CD  1 
ATOM   96   O OE1 . GLU A 1 12  ? -9.66491  -13.47417 48.33392 1.000 35.46170 ? 14  GLU A OE1 1 
ATOM   97   O OE2 . GLU A 1 12  ? -8.64781  -12.06513 46.96533 1.000 35.52621 ? 14  GLU A OE2 1 
ATOM   98   N N   . GLY A 1 13  ? -5.05606  -16.61969 49.71984 1.000 32.34413 ? 15  GLY A N   1 
ATOM   99   C CA  . GLY A 1 13  ? -4.92029  -17.98500 50.22011 1.000 32.77340 ? 15  GLY A CA  1 
ATOM   100  C C   . GLY A 1 13  ? -3.74067  -18.19792 51.15228 1.000 35.37028 ? 15  GLY A C   1 
ATOM   101  O O   . GLY A 1 13  ? -3.58892  -19.30284 51.68531 1.000 37.39915 ? 15  GLY A O   1 
ATOM   102  N N   . CYS A 1 14  ? -2.90872  -17.16773 51.35039 1.000 30.61291 ? 16  CYS A N   1 
ATOM   103  C CA  . CYS A 1 14  ? -1.72733  -17.20226 52.20846 1.000 31.63305 ? 16  CYS A CA  1 
ATOM   104  C C   . CYS A 1 14  ? -1.91087  -16.52401 53.56580 1.000 33.07051 ? 16  CYS A C   1 
ATOM   105  O O   . CYS A 1 14  ? -1.02727  -16.65278 54.42707 1.000 30.65028 ? 16  CYS A O   1 
ATOM   106  C CB  . CYS A 1 14  ? -0.55501  -16.52918 51.49428 1.000 29.96467 ? 16  CYS A CB  1 
ATOM   107  S SG  . CYS A 1 14  ? -0.14849  -17.23383 49.87573 1.000 38.59153 ? 16  CYS A SG  1 
ATOM   108  N N   . MET A 1 15  ? -3.00513  -15.79183 53.77690 1.000 29.59316 ? 17  MET A N   1 
ATOM   109  C CA  . MET A 1 15  ? -3.19732  -15.04791 55.01683 1.000 28.77544 ? 17  MET A CA  1 
ATOM   110  C C   . MET A 1 15  ? -3.75789  -15.95188 56.10383 1.000 30.70968 ? 17  MET A C   1 
ATOM   111  O O   . MET A 1 15  ? -4.76145  -16.63857 55.89858 1.000 29.97814 ? 17  MET A O   1 
ATOM   112  C CB  . MET A 1 15  ? -4.13974  -13.86073 54.81531 1.000 29.01772 ? 17  MET A CB  1 
ATOM   113  C CG  . MET A 1 15  ? -3.67435  -12.86104 53.77868 1.000 30.51873 ? 17  MET A CG  1 
ATOM   114  S SD  . MET A 1 15  ? -1.92801  -12.42424 53.93577 1.000 34.79027 ? 17  MET A SD  1 
ATOM   115  C CE  . MET A 1 15  ? -1.84223  -11.68383 55.59155 1.000 29.20787 ? 17  MET A CE  1 
ATOM   116  N N   . VAL A 1 16  ? -3.12400  -15.91667 57.27192 1.000 28.05683 ? 18  VAL A N   1 
ATOM   117  C CA  . VAL A 1 16  ? -3.54631  -16.67354 58.44076 1.000 33.46435 ? 18  VAL A CA  1 
ATOM   118  C C   . VAL A 1 16  ? -3.56085  -15.73186 59.63759 1.000 33.85004 ? 18  VAL A C   1 
ATOM   119  O O   . VAL A 1 16  ? -3.00859  -14.62848 59.59678 1.000 29.54798 ? 18  VAL A O   1 
ATOM   120  C CB  . VAL A 1 16  ? -2.62176  -17.88519 58.70324 1.000 32.31977 ? 18  VAL A CB  1 
ATOM   121  C CG1 . VAL A 1 16  ? -2.62027  -18.79527 57.48545 1.000 28.48208 ? 18  VAL A CG1 1 
ATOM   122  C CG2 . VAL A 1 16  ? -1.20126  -17.42154 59.00608 1.000 27.55240 ? 18  VAL A CG2 1 
ATOM   123  N N   . GLN A 1 17  ? -4.23826  -16.17123 60.69834 1.000 32.09095 ? 19  GLN A N   1 
ATOM   124  C CA  . GLN A 1 17  ? -4.24383  -15.48321 61.98202 1.000 34.83637 ? 19  GLN A CA  1 
ATOM   125  C C   . GLN A 1 17  ? -3.14077  -16.03555 62.88122 1.000 35.38288 ? 19  GLN A C   1 
ATOM   126  O O   . GLN A 1 17  ? -2.93145  -17.25055 62.94425 1.000 32.18620 ? 19  GLN A O   1 
ATOM   127  C CB  . GLN A 1 17  ? -5.60024  -15.66265 62.66398 1.000 35.66379 ? 19  GLN A CB  1 
ATOM   128  C CG  . GLN A 1 17  ? -5.79936  -14.80770 63.88699 1.000 40.04965 ? 19  GLN A CG  1 
ATOM   129  C CD  . GLN A 1 17  ? -7.05041  -15.19205 64.64564 1.000 45.63590 ? 19  GLN A CD  1 
ATOM   130  O OE1 . GLN A 1 17  ? -7.87801  -14.33769 64.96109 1.000 49.48978 ? 19  GLN A OE1 1 
ATOM   131  N NE2 . GLN A 1 17  ? -7.19243  -16.48315 64.95370 1.000 50.73441 ? 19  GLN A NE2 1 
ATOM   132  N N   . VAL A 1 18  ? -2.43599  -15.14343 63.57639 1.000 32.62338 ? 20  VAL A N   1 
ATOM   133  C CA  . VAL A 1 18  ? -1.38830  -15.55101 64.51360 1.000 32.21979 ? 20  VAL A CA  1 
ATOM   134  C C   . VAL A 1 18  ? -1.65765  -14.89610 65.85479 1.000 37.54362 ? 20  VAL A C   1 
ATOM   135  O O   . VAL A 1 18  ? -1.62858  -13.66080 65.97485 1.000 34.03323 ? 20  VAL A O   1 
ATOM   136  C CB  . VAL A 1 18  ? 0.02593   -15.19834 64.02345 1.000 32.66885 ? 20  VAL A CB  1 
ATOM   137  C CG1 . VAL A 1 18  ? 1.06598   -15.61483 65.07263 1.000 31.68348 ? 20  VAL A CG1 1 
ATOM   138  C CG2 . VAL A 1 18  ? 0.31835   -15.90594 62.71976 1.000 30.37549 ? 20  VAL A CG2 1 
ATOM   139  N N   . THR A 1 19  ? -1.90160  -15.71296 66.86591 1.000 37.95236 ? 21  THR A N   1 
ATOM   140  C CA  . THR A 1 19  ? -2.12790  -15.19825 68.20200 1.000 38.17981 ? 21  THR A CA  1 
ATOM   141  C C   . THR A 1 19  ? -0.99508  -15.64188 69.11489 1.000 39.25637 ? 21  THR A C   1 
ATOM   142  O O   . THR A 1 19  ? -0.47399  -16.76043 68.99939 1.000 36.43357 ? 21  THR A O   1 
ATOM   143  C CB  . THR A 1 19  ? -3.49305  -15.63543 68.75002 1.000 40.33987 ? 21  THR A CB  1 
ATOM   144  O OG1 . THR A 1 19  ? -4.51931  -15.06454 67.93136 1.000 42.27093 ? 21  THR A OG1 1 
ATOM   145  C CG2 . THR A 1 19  ? -3.69798  -15.12011 70.17639 1.000 41.19312 ? 21  THR A CG2 1 
ATOM   146  N N   . CYS A 1 20  ? -0.58655  -14.71501 69.97159 1.000 39.40472 ? 22  CYS A N   1 
ATOM   147  C CA  . CYS A 1 20  ? 0.40384   -14.95044 71.00684 1.000 41.82988 ? 22  CYS A CA  1 
ATOM   148  C C   . CYS A 1 20  ? -0.15186  -14.26467 72.24264 1.000 45.46647 ? 22  CYS A C   1 
ATOM   149  O O   . CYS A 1 20  ? -0.17607  -13.02970 72.30601 1.000 47.38144 ? 22  CYS A O   1 
ATOM   150  C CB  . CYS A 1 20  ? 1.76337   -14.38338 70.60552 1.000 39.21716 ? 22  CYS A CB  1 
ATOM   151  S SG  . CYS A 1 20  ? 3.10476   -14.89410 71.64687 1.000 51.75077 ? 22  CYS A SG  1 
ATOM   152  N N   . GLY A 1 21  ? -0.65365  -15.04844 73.18846 1.000 49.27725 ? 23  GLY A N   1 
ATOM   153  C CA  . GLY A 1 21  ? -1.26481  -14.46052 74.36963 1.000 47.58992 ? 23  GLY A CA  1 
ATOM   154  C C   . GLY A 1 21  ? -2.51685  -13.68599 74.00769 1.000 48.28499 ? 23  GLY A C   1 
ATOM   155  O O   . GLY A 1 21  ? -3.43095  -14.20138 73.35550 1.000 47.97729 ? 23  GLY A O   1 
ATOM   156  N N   . THR A 1 22  ? -2.57829  -12.42544 74.43305 1.000 47.66609 ? 24  THR A N   1 
ATOM   157  C CA  . THR A 1 22  ? -3.70206  -11.56191 74.09571 1.000 48.61883 ? 24  THR A CA  1 
ATOM   158  C C   . THR A 1 22  ? -3.56229  -10.88174 72.73266 1.000 45.19291 ? 24  THR A C   1 
ATOM   159  O O   . THR A 1 22  ? -4.52989  -10.27150 72.26511 1.000 43.97353 ? 24  THR A O   1 
ATOM   160  C CB  . THR A 1 22  ? -3.88324  -10.48121 75.17071 1.000 51.60141 ? 24  THR A CB  1 
ATOM   161  O OG1 . THR A 1 22  ? -2.64681  -9.77999  75.35585 1.000 55.60087 ? 24  THR A OG1 1 
ATOM   162  C CG2 . THR A 1 22  ? -4.28906  -11.11248 76.49037 1.000 56.91760 ? 24  THR A CG2 1 
ATOM   163  N N   . THR A 1 23  ? -2.39919  -10.96861 72.08670 1.000 46.12066 ? 25  THR A N   1 
ATOM   164  C CA  . THR A 1 23  ? -2.13700  -10.24785 70.84423 1.000 39.97490 ? 25  THR A CA  1 
ATOM   165  C C   . THR A 1 23  ? -2.49822  -11.10786 69.64218 1.000 39.29841 ? 25  THR A C   1 
ATOM   166  O O   . THR A 1 23  ? -2.01638  -12.23497 69.51645 1.000 37.38335 ? 25  THR A O   1 
ATOM   167  C CB  . THR A 1 23  ? -0.66679  -9.84068  70.75725 1.000 40.42196 ? 25  THR A CB  1 
ATOM   168  O OG1 . THR A 1 23  ? -0.31965  -9.05314  71.90051 1.000 40.97319 ? 25  THR A OG1 1 
ATOM   169  C CG2 . THR A 1 23  ? -0.40319  -9.02811  69.49264 1.000 40.24312 ? 25  THR A CG2 1 
ATOM   170  N N   . THR A 1 24  ? -3.32553  -10.56559 68.74955 1.000 36.59621 ? 26  THR A N   1 
ATOM   171  C CA  . THR A 1 24  ? -3.64196  -11.20575 67.47927 1.000 36.92128 ? 26  THR A CA  1 
ATOM   172  C C   . THR A 1 24  ? -3.23841  -10.29796 66.32270 1.000 37.97437 ? 26  THR A C   1 
ATOM   173  O O   . THR A 1 24  ? -3.52094  -9.09182  66.34406 1.000 33.70235 ? 26  THR A O   1 
ATOM   174  C CB  . THR A 1 24  ? -5.12729  -11.54110 67.39017 1.000 40.72054 ? 26  THR A CB  1 
ATOM   175  O OG1 . THR A 1 24  ? -5.37926  -12.75072 68.12278 1.000 47.83813 ? 26  THR A OG1 1 
ATOM   176  C CG2 . THR A 1 24  ? -5.53109  -11.77630 65.95314 1.000 44.04474 ? 26  THR A CG2 1 
ATOM   177  N N   . LEU A 1 25  ? -2.55456  -10.86842 65.33149 1.000 32.54316 ? 27  LEU A N   1 
ATOM   178  C CA  . LEU A 1 25  ? -2.31455  -10.15979 64.07302 1.000 36.12673 ? 27  LEU A CA  1 
ATOM   179  C C   . LEU A 1 25  ? -2.26383  -11.18515 62.94656 1.000 31.74293 ? 27  LEU A C   1 
ATOM   180  O O   . LEU A 1 25  ? -2.61802  -12.35241 63.13431 1.000 33.38592 ? 27  LEU A O   1 
ATOM   181  C CB  . LEU A 1 25  ? -1.04546  -9.30254  64.16166 1.000 32.78153 ? 27  LEU A CB  1 
ATOM   182  C CG  . LEU A 1 25  ? 0.17579   -10.00796 64.74672 1.000 35.42934 ? 27  LEU A CG  1 
ATOM   183  C CD1 . LEU A 1 25  ? 0.79353   -10.96584 63.72646 1.000 31.76793 ? 27  LEU A CD1 1 
ATOM   184  C CD2 . LEU A 1 25  ? 1.18633   -8.99593  65.22137 1.000 29.87938 ? 27  LEU A CD2 1 
ATOM   185  N N   . ASN A 1 26  ? -1.78562  -10.75763 61.77930 1.000 26.50501 ? 28  ASN A N   1 
ATOM   186  C CA  . ASN A 1 26  ? -1.80725  -11.57264 60.57346 1.000 27.72615 ? 28  ASN A CA  1 
ATOM   187  C C   . ASN A 1 26  ? -0.43171  -12.15078 60.27896 1.000 28.73485 ? 28  ASN A C   1 
ATOM   188  O O   . ASN A 1 26  ? 0.59032   -11.56343 60.62446 1.000 26.35086 ? 28  ASN A O   1 
ATOM   189  C CB  . ASN A 1 26  ? -2.28922  -10.75029 59.37033 1.000 27.86061 ? 28  ASN A CB  1 
ATOM   190  C CG  . ASN A 1 26  ? -3.57378  -10.02090 59.65749 1.000 26.32914 ? 28  ASN A CG  1 
ATOM   191  O OD1 . ASN A 1 26  ? -4.64904  -10.60966 59.61875 1.000 28.71442 ? 28  ASN A OD1 1 
ATOM   192  N ND2 . ASN A 1 26  ? -3.47217  -8.72842  59.96320 1.000 27.78666 ? 28  ASN A ND2 1 
ATOM   193  N N   . GLY A 1 27  ? -0.42028  -13.32897 59.64814 1.000 27.64076 ? 29  GLY A N   1 
ATOM   194  C CA  . GLY A 1 27  ? 0.80792   -13.91537 59.16025 1.000 26.29593 ? 29  GLY A CA  1 
ATOM   195  C C   . GLY A 1 27  ? 0.64732   -14.35067 57.71448 1.000 25.59777 ? 29  GLY A C   1 
ATOM   196  O O   . GLY A 1 27  ? -0.45834  -14.53343 57.22183 1.000 29.39778 ? 29  GLY A O   1 
ATOM   197  N N   . LEU A 1 28  ? 1.77879   -14.52040 57.04792 1.000 28.72191 ? 30  LEU A N   1 
ATOM   198  C CA  . LEU A 1 28  ? 1.82409   -14.96234 55.65837 1.000 31.00100 ? 30  LEU A CA  1 
ATOM   199  C C   . LEU A 1 28  ? 2.31625   -16.40174 55.62155 1.000 29.29198 ? 30  LEU A C   1 
ATOM   200  O O   . LEU A 1 28  ? 3.45968   -16.67430 55.99635 1.000 29.41691 ? 30  LEU A O   1 
ATOM   201  C CB  . LEU A 1 28  ? 2.75021   -14.06684 54.83085 1.000 30.17458 ? 30  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 28  ? 2.78241   -14.28818 53.31744 1.000 33.16653 ? 30  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 28  ? 1.45939   -13.86073 52.66828 1.000 27.86070 ? 30  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 28  ? 3.96868   -13.53994 52.71433 1.000 26.13399 ? 30  LEU A CD2 1 
ATOM   205  N N   . TRP A 1 29  ? 1.48321   -17.30353 55.12788 1.000 27.94524 ? 31  TRP A N   1 
ATOM   206  C CA  . TRP A 1 29  ? 1.76112   -18.73954 55.17664 1.000 29.61227 ? 31  TRP A CA  1 
ATOM   207  C C   . TRP A 1 29  ? 2.20081   -19.19126 53.78554 1.000 30.81799 ? 31  TRP A C   1 
ATOM   208  O O   . TRP A 1 29  ? 1.37955   -19.34364 52.88097 1.000 32.28165 ? 31  TRP A O   1 
ATOM   209  C CB  . TRP A 1 29  ? 0.52512   -19.48306 55.67961 1.000 31.48889 ? 31  TRP A CB  1 
ATOM   210  C CG  . TRP A 1 29  ? 0.63569   -20.99395 55.76566 1.000 32.52151 ? 31  TRP A CG  1 
ATOM   211  C CD1 . TRP A 1 29  ? 1.76835   -21.73096 55.89425 1.000 30.65813 ? 31  TRP A CD1 1 
ATOM   212  C CD2 . TRP A 1 29  ? -0.45219  -21.92685 55.70571 1.000 33.82941 ? 31  TRP A CD2 1 
ATOM   213  N NE1 . TRP A 1 29  ? 1.45817   -23.07945 55.92900 1.000 37.27690 ? 31  TRP A NE1 1 
ATOM   214  C CE2 . TRP A 1 29  ? 0.09934   -23.22279 55.82350 1.000 36.59761 ? 31  TRP A CE2 1 
ATOM   215  C CE3 . TRP A 1 29  ? -1.83985  -21.79019 55.57550 1.000 32.33752 ? 31  TRP A CE3 1 
ATOM   216  C CZ2 . TRP A 1 29  ? -0.68658  -24.37788 55.80014 1.000 33.56846 ? 31  TRP A CZ2 1 
ATOM   217  C CZ3 . TRP A 1 29  ? -2.62525  -22.94009 55.55202 1.000 39.75548 ? 31  TRP A CZ3 1 
ATOM   218  C CH2 . TRP A 1 29  ? -2.03917  -24.22111 55.66928 1.000 35.31346 ? 31  TRP A CH2 1 
ATOM   219  N N   . LEU A 1 30  ? 3.50692   -19.40277 53.62372 1.000 33.01578 ? 32  LEU A N   1 
ATOM   220  C CA  . LEU A 1 30  ? 4.11797   -19.85018 52.37775 1.000 31.70426 ? 32  LEU A CA  1 
ATOM   221  C C   . LEU A 1 30  ? 4.87046   -21.15864 52.61726 1.000 35.98448 ? 32  LEU A C   1 
ATOM   222  O O   . LEU A 1 30  ? 5.74160   -21.22755 53.49216 1.000 32.38758 ? 32  LEU A O   1 
ATOM   223  C CB  . LEU A 1 30  ? 5.07358   -18.78886 51.84368 1.000 30.78508 ? 32  LEU A CB  1 
ATOM   224  C CG  . LEU A 1 30  ? 4.48393   -17.41504 51.48670 1.000 30.87386 ? 32  LEU A CG  1 
ATOM   225  C CD1 . LEU A 1 30  ? 5.60526   -16.41259 51.34838 1.000 28.14416 ? 32  LEU A CD1 1 
ATOM   226  C CD2 . LEU A 1 30  ? 3.68620   -17.50513 50.18052 1.000 28.73902 ? 32  LEU A CD2 1 
ATOM   227  N N   . ASP A 1 31  ? 4.56710   -22.18147 51.82075 1.000 35.18801 ? 33  ASP A N   1 
ATOM   228  C CA  . ASP A 1 31  ? 5.07676   -23.54669 52.08050 1.000 35.74155 ? 33  ASP A CA  1 
ATOM   229  C C   . ASP A 1 31  ? 4.76522   -23.87298 53.53864 1.000 34.49711 ? 33  ASP A C   1 
ATOM   230  O O   . ASP A 1 31  ? 3.61991   -23.67962 53.97736 1.000 31.36991 ? 33  ASP A O   1 
ATOM   231  C CB  . ASP A 1 31  ? 6.55261   -23.63846 51.69633 1.000 34.11262 ? 33  ASP A CB  1 
ATOM   232  C CG  . ASP A 1 31  ? 6.79140   -23.30585 50.24062 1.000 43.16898 ? 33  ASP A CG  1 
ATOM   233  O OD1 . ASP A 1 31  ? 5.98666   -23.76858 49.40583 1.000 48.73784 ? 33  ASP A OD1 1 
ATOM   234  O OD2 . ASP A 1 31  ? 7.76389   -22.57857 49.92745 1.000 48.47825 ? 33  ASP A OD2 1 
ATOM   235  N N   . ASP A 1 32  ? 5.73667   -24.32567 54.33009 1.000 31.11967 ? 34  ASP A N   1 
ATOM   236  C CA  . ASP A 1 32  ? 5.49709   -24.71295 55.71133 1.000 36.55246 ? 34  ASP A CA  1 
ATOM   237  C C   . ASP A 1 32  ? 6.00339   -23.66468 56.69977 1.000 34.75464 ? 34  ASP A C   1 
ATOM   238  O O   . ASP A 1 32  ? 6.39476   -24.00532 57.81947 1.000 33.29335 ? 34  ASP A O   1 
ATOM   239  C CB  . ASP A 1 32  ? 6.13370   -26.07971 55.99107 1.000 39.08027 ? 34  ASP A CB  1 
ATOM   240  C CG  . ASP A 1 32  ? 7.63773   -26.08955 55.76643 1.000 44.38002 ? 34  ASP A CG  1 
ATOM   241  O OD1 . ASP A 1 32  ? 8.17372   -25.12565 55.18096 1.000 47.79915 ? 34  ASP A OD1 1 
ATOM   242  O OD2 . ASP A 1 32  ? 8.28880   -27.07213 56.17886 1.000 52.45075 ? 34  ASP A OD2 1 
ATOM   243  N N   . VAL A 1 33  ? 6.01652   -22.39161 56.30215 1.000 30.76248 ? 35  VAL A N   1 
ATOM   244  C CA  . VAL A 1 33  ? 6.50101   -21.31139 57.15802 1.000 32.68491 ? 35  VAL A CA  1 
ATOM   245  C C   . VAL A 1 33  ? 5.46240   -20.19854 57.19016 1.000 31.63161 ? 35  VAL A C   1 
ATOM   246  O O   . VAL A 1 33  ? 4.92576   -19.81302 56.14431 1.000 31.43398 ? 35  VAL A O   1 
ATOM   247  C CB  . VAL A 1 33  ? 7.85592   -20.76124 56.66803 1.000 31.58746 ? 35  VAL A CB  1 
ATOM   248  C CG1 . VAL A 1 33  ? 8.25080   -19.51958 57.47814 1.000 29.23110 ? 35  VAL A CG1 1 
ATOM   249  C CG2 . VAL A 1 33  ? 8.92095   -21.82834 56.76182 1.000 29.46146 ? 35  VAL A CG2 1 
ATOM   250  N N   . VAL A 1 34  ? 5.17990   -19.68183 58.38849 1.000 29.34167 ? 36  VAL A N   1 
ATOM   251  C CA  . VAL A 1 34  ? 4.34454   -18.49420 58.56142 1.000 31.47860 ? 36  VAL A CA  1 
ATOM   252  C C   . VAL A 1 34  ? 5.24015   -17.32488 58.97068 1.000 30.79365 ? 36  VAL A C   1 
ATOM   253  O O   . VAL A 1 34  ? 5.95573   -17.39697 59.98032 1.000 31.70057 ? 36  VAL A O   1 
ATOM   254  C CB  . VAL A 1 34  ? 3.23489   -18.73363 59.59371 1.000 31.03385 ? 36  VAL A CB  1 
ATOM   255  C CG1 . VAL A 1 34  ? 2.48110   -17.44604 59.88807 1.000 31.18448 ? 36  VAL A CG1 1 
ATOM   256  C CG2 . VAL A 1 34  ? 2.28805   -19.84529 59.10468 1.000 32.60106 ? 36  VAL A CG2 1 
ATOM   257  N N   . TYR A 1 35  ? 5.20690   -16.25271 58.18597 1.000 30.23066 ? 37  TYR A N   1 
ATOM   258  C CA  . TYR A 1 35  ? 5.95664   -15.03589 58.47528 1.000 28.72758 ? 37  TYR A CA  1 
ATOM   259  C C   . TYR A 1 35  ? 5.03442   -14.02887 59.15340 1.000 29.94992 ? 37  TYR A C   1 
ATOM   260  O O   . TYR A 1 35  ? 3.89548   -13.84413 58.71740 1.000 28.27007 ? 37  TYR A O   1 
ATOM   261  C CB  . TYR A 1 35  ? 6.51482   -14.42923 57.18576 1.000 28.86064 ? 37  TYR A CB  1 
ATOM   262  C CG  . TYR A 1 35  ? 7.36165   -15.35918 56.38859 1.000 27.80722 ? 37  TYR A CG  1 
ATOM   263  C CD1 . TYR A 1 35  ? 6.78286   -16.35971 55.61093 1.000 32.06026 ? 37  TYR A CD1 1 
ATOM   264  C CD2 . TYR A 1 35  ? 8.74678   -15.25217 56.40115 1.000 33.48964 ? 37  TYR A CD2 1 
ATOM   265  C CE1 . TYR A 1 35  ? 7.55852   -17.23984 54.88230 1.000 30.63516 ? 37  TYR A CE1 1 
ATOM   266  C CE2 . TYR A 1 35  ? 9.53834   -16.13314 55.65731 1.000 31.68809 ? 37  TYR A CE2 1 
ATOM   267  C CZ  . TYR A 1 35  ? 8.92782   -17.11603 54.90297 1.000 31.47749 ? 37  TYR A CZ  1 
ATOM   268  O OH  . TYR A 1 35  ? 9.67968   -17.99224 54.15941 1.000 34.43689 ? 37  TYR A OH  1 
ATOM   269  N N   . CYS A 1 36  ? 5.52357   -13.35566 60.19776 1.000 29.26618 ? 38  CYS A N   1 
ATOM   270  C CA  . CYS A 1 36  ? 4.71529   -12.33109 60.85133 1.000 26.73816 ? 38  CYS A CA  1 
ATOM   271  C C   . CYS A 1 36  ? 5.64126   -11.38580 61.61771 1.000 27.56518 ? 38  CYS A C   1 
ATOM   272  O O   . CYS A 1 36  ? 6.82260   -11.68898 61.80438 1.000 27.04089 ? 38  CYS A O   1 
ATOM   273  C CB  . CYS A 1 36  ? 3.65473   -12.96760 61.76949 1.000 29.62302 ? 38  CYS A CB  1 
ATOM   274  S SG  . CYS A 1 36  ? 4.25096   -13.63564 63.33186 1.000 34.40364 ? 38  CYS A SG  1 
ATOM   275  N N   . PRO A 1 37  ? 5.15615   -10.20515 62.01685 1.000 28.75840 ? 39  PRO A N   1 
ATOM   276  C CA  . PRO A 1 37  ? 6.02880   -9.29190  62.77201 1.000 27.52367 ? 39  PRO A CA  1 
ATOM   277  C C   . PRO A 1 37  ? 6.42155   -9.93121  64.10063 1.000 27.01857 ? 39  PRO A C   1 
ATOM   278  O O   . PRO A 1 37  ? 5.61454   -10.58958 64.75721 1.000 29.14823 ? 39  PRO A O   1 
ATOM   279  C CB  . PRO A 1 37  ? 5.16516   -8.03599  62.96575 1.000 27.21333 ? 39  PRO A CB  1 
ATOM   280  C CG  . PRO A 1 37  ? 4.04331   -8.16600  61.92639 1.000 28.88751 ? 39  PRO A CG  1 
ATOM   281  C CD  . PRO A 1 37  ? 3.81207   -9.63878  61.80951 1.000 27.72568 ? 39  PRO A CD  1 
ATOM   282  N N   . ARG A 1 38  ? 7.68942   -9.77652  64.47054 1.000 27.50516 ? 40  ARG A N   1 
ATOM   283  C CA  . ARG A 1 38  ? 8.14910   -10.32868 65.74235 1.000 27.51852 ? 40  ARG A CA  1 
ATOM   284  C C   . ARG A 1 38  ? 7.53469   -9.62480  66.95309 1.000 29.21466 ? 40  ARG A C   1 
ATOM   285  O O   . ARG A 1 38  ? 7.55004   -10.19144 68.05376 1.000 26.92815 ? 40  ARG A O   1 
ATOM   286  C CB  . ARG A 1 38  ? 9.67584   -10.26738 65.81126 1.000 27.25972 ? 40  ARG A CB  1 
ATOM   287  C CG  . ARG A 1 38  ? 10.24477  -8.88129  66.06329 1.000 27.32062 ? 40  ARG A CG  1 
ATOM   288  C CD  . ARG A 1 38  ? 11.76219  -8.91371  66.17990 1.000 27.97972 ? 40  ARG A CD  1 
ATOM   289  N NE  . ARG A 1 38  ? 12.33516  -7.57016  66.19774 1.000 26.67855 ? 40  ARG A NE  1 
ATOM   290  C CZ  . ARG A 1 38  ? 13.62329  -7.30589  66.39906 1.000 30.36460 ? 40  ARG A CZ  1 
ATOM   291  N NH1 . ARG A 1 38  ? 14.48229  -8.29328  66.58137 1.000 24.90096 ? 40  ARG A NH1 1 
ATOM   292  N NH2 . ARG A 1 38  ? 14.05700  -6.04571  66.42512 1.000 27.70871 ? 40  ARG A NH2 1 
ATOM   293  N N   . HIS A 1 39  ? 6.95217   -8.42458  66.78309 1.000 28.90140 ? 41  HIS A N   1 
ATOM   294  C CA  . HIS A 1 39  ? 6.41820   -7.76062  67.97144 1.000 30.89609 ? 41  HIS A CA  1 
ATOM   295  C C   . HIS A 1 39  ? 5.15466   -8.41803  68.49950 1.000 29.65822 ? 41  HIS A C   1 
ATOM   296  O O   . HIS A 1 39  ? 4.63236   -7.97098  69.53775 1.000 29.12893 ? 41  HIS A O   1 
ATOM   297  C CB  . HIS A 1 39  ? 6.18150   -6.25518  67.73424 1.000 30.35160 ? 41  HIS A CB  1 
ATOM   298  C CG  . HIS A 1 39  ? 5.15683   -5.92652  66.68192 1.000 28.94067 ? 41  HIS A CG  1 
ATOM   299  N ND1 . HIS A 1 39  ? 3.83084   -6.29179  66.78305 1.000 28.14489 ? 41  HIS A ND1 1 
ATOM   300  C CD2 . HIS A 1 39  ? 5.25961   -5.19648  65.54431 1.000 28.03543 ? 41  HIS A CD2 1 
ATOM   301  C CE1 . HIS A 1 39  ? 3.16651   -5.82791  65.73725 1.000 30.44439 ? 41  HIS A CE1 1 
ATOM   302  N NE2 . HIS A 1 39  ? 4.01177   -5.16130  64.96978 1.000 30.62856 ? 41  HIS A NE2 1 
ATOM   303  N N   . VAL A 1 40  ? 4.67366   -9.46997  67.83404 1.000 27.05687 ? 42  VAL A N   1 
ATOM   304  C CA  . VAL A 1 40  ? 3.59001   -10.27374 68.38601 1.000 29.81097 ? 42  VAL A CA  1 
ATOM   305  C C   . VAL A 1 40  ? 3.96957   -10.88158 69.73929 1.000 34.25093 ? 42  VAL A C   1 
ATOM   306  O O   . VAL A 1 40  ? 3.08448   -11.21425 70.53458 1.000 33.82404 ? 42  VAL A O   1 
ATOM   307  C CB  . VAL A 1 40  ? 3.17704   -11.37933 67.38449 1.000 28.12170 ? 42  VAL A CB  1 
ATOM   308  C CG1 . VAL A 1 40  ? 4.24416   -12.45318 67.28080 1.000 28.78878 ? 42  VAL A CG1 1 
ATOM   309  C CG2 . VAL A 1 40  ? 1.81951   -11.99229 67.77617 1.000 32.06002 ? 42  VAL A CG2 1 
ATOM   310  N N   . ILE A 1 41  ? 5.26390   -11.03092 70.03251 1.000 29.75101 ? 43  ILE A N   1 
ATOM   311  C CA  . ILE A 1 41  ? 5.65830   -11.65593 71.29970 1.000 35.85106 ? 43  ILE A CA  1 
ATOM   312  C C   . ILE A 1 41  ? 5.81091   -10.61885 72.41163 1.000 39.15803 ? 43  ILE A C   1 
ATOM   313  O O   . ILE A 1 41  ? 6.23098   -10.95157 73.52518 1.000 39.11600 ? 43  ILE A O   1 
ATOM   314  C CB  . ILE A 1 41  ? 6.95597   -12.47007 71.15133 1.000 31.45726 ? 43  ILE A CB  1 
ATOM   315  C CG1 . ILE A 1 41  ? 8.15954   -11.53583 70.95804 1.000 33.96897 ? 43  ILE A CG1 1 
ATOM   316  C CG2 . ILE A 1 41  ? 6.83938   -13.47331 70.00110 1.000 29.14517 ? 43  ILE A CG2 1 
ATOM   317  C CD1 . ILE A 1 41  ? 9.47742   -12.30567 70.72503 1.000 34.76885 ? 43  ILE A CD1 1 
ATOM   318  N N   . CYS A 1 42  ? 5.44968   -9.36756  72.13650 1.000 37.58713 ? 44  CYS A N   1 
ATOM   319  C CA  . CYS A 1 42  ? 5.55105   -8.29932  73.12434 1.000 37.74960 ? 44  CYS A CA  1 
ATOM   320  C C   . CYS A 1 42  ? 4.33516   -8.22477  74.04215 1.000 44.30796 ? 44  CYS A C   1 
ATOM   321  O O   . CYS A 1 42  ? 3.19731   -8.45038  73.62568 1.000 43.29055 ? 44  CYS A O   1 
ATOM   322  C CB  . CYS A 1 42  ? 5.70210   -6.94943  72.44080 1.000 42.45926 ? 44  CYS A CB  1 
ATOM   323  S SG  . CYS A 1 42  ? 7.35336   -6.59881  71.99868 1.000 55.32615 ? 44  CYS A SG  1 
ATOM   324  N N   . THR A 1 43  ? 4.58426   -7.86379  75.29692 1.000 48.61084 ? 45  THR A N   1 
ATOM   325  C CA  . THR A 1 43  ? 3.53437   -7.40520  76.19573 1.000 46.66837 ? 45  THR A CA  1 
ATOM   326  C C   . THR A 1 43  ? 3.68911   -5.90784  76.41022 1.000 47.33679 ? 45  THR A C   1 
ATOM   327  O O   . THR A 1 43  ? 4.69989   -5.30557  76.03433 1.000 48.44026 ? 45  THR A O   1 
ATOM   328  C CB  . THR A 1 43  ? 3.58792   -8.13660  77.53724 1.000 49.24729 ? 45  THR A CB  1 
ATOM   329  O OG1 . THR A 1 43  ? 4.72635   -7.68160  78.27205 1.000 48.22586 ? 45  THR A OG1 1 
ATOM   330  C CG2 . THR A 1 43  ? 3.69610   -9.63438  77.32115 1.000 50.89382 ? 45  THR A CG2 1 
ATOM   331  N N   . SER A 1 44  ? 2.67856   -5.30419  77.03925 1.000 49.51887 ? 46  SER A N   1 
ATOM   332  C CA  . SER A 1 44  ? 2.72768   -3.86180  77.26184 1.000 48.93053 ? 46  SER A CA  1 
ATOM   333  C C   . SER A 1 44  ? 3.89993   -3.45698  78.14807 1.000 52.54835 ? 46  SER A C   1 
ATOM   334  O O   . SER A 1 44  ? 4.45040   -2.36316  77.98084 1.000 56.43936 ? 46  SER A O   1 
ATOM   335  C CB  . SER A 1 44  ? 1.40858   -3.38290  77.85390 1.000 55.26518 ? 46  SER A CB  1 
ATOM   336  O OG  . SER A 1 44  ? 0.46440   -3.16202  76.81855 1.000 61.52631 ? 46  SER A OG  1 
ATOM   337  N N   . GLU A 1 45  ? 4.30489   -4.31763  79.08431 1.000 50.09368 ? 47  GLU A N   1 
ATOM   338  C CA  . GLU A 1 45  ? 5.48888   -4.04461  79.89000 1.000 52.10309 ? 47  GLU A CA  1 
ATOM   339  C C   . GLU A 1 45  ? 6.78430   -4.26908  79.11752 1.000 54.19635 ? 47  GLU A C   1 
ATOM   340  O O   . GLU A 1 45  ? 7.85577   -3.93412  79.63037 1.000 56.47882 ? 47  GLU A O   1 
ATOM   341  C CB  . GLU A 1 45  ? 5.48327   -4.91779  81.14617 1.000 58.97890 ? 47  GLU A CB  1 
ATOM   342  C CG  . GLU A 1 45  ? 5.80187   -6.37883  80.86744 1.000 60.02707 ? 47  GLU A CG  1 
ATOM   343  C CD  . GLU A 1 45  ? 5.06641   -7.33952  81.78509 1.000 71.18001 ? 47  GLU A CD  1 
ATOM   344  O OE1 . GLU A 1 45  ? 4.07558   -7.96672  81.33152 1.000 63.76168 ? 47  GLU A OE1 1 
ATOM   345  O OE2 . GLU A 1 45  ? 5.49308   -7.47573  82.95465 1.000 78.16962 ? 47  GLU A OE2 1 
ATOM   346  N N   . ASP A 1 46  ? 6.71399   -4.83275  77.90682 1.000 53.50496 ? 48  ASP A N   1 
ATOM   347  C CA  . ASP A 1 46  ? 7.88434   -5.03586  77.05849 1.000 51.93366 ? 48  ASP A CA  1 
ATOM   348  C C   . ASP A 1 46  ? 8.02501   -3.98466  75.96354 1.000 47.78514 ? 48  ASP A C   1 
ATOM   349  O O   . ASP A 1 46  ? 9.14013   -3.78310  75.46367 1.000 40.92874 ? 48  ASP A O   1 
ATOM   350  C CB  . ASP A 1 46  ? 7.82832   -6.41756  76.38225 1.000 49.32379 ? 48  ASP A CB  1 
ATOM   351  C CG  . ASP A 1 46  ? 7.94880   -7.57293  77.36859 1.000 54.84078 ? 48  ASP A CG  1 
ATOM   352  O OD1 . ASP A 1 46  ? 8.80887   -7.49991  78.28646 1.000 54.75481 ? 48  ASP A OD1 1 
ATOM   353  O OD2 . ASP A 1 46  ? 7.18638   -8.56157  77.20157 1.000 52.64059 ? 48  ASP A OD2 1 
ATOM   354  N N   . MET A 1 47  ? 6.92826   -3.30155  75.60583 1.000 48.15071 ? 49  MET A N   1 
ATOM   355  C CA  . MET A 1 47  ? 6.86380   -2.54668  74.35581 1.000 43.32959 ? 49  MET A CA  1 
ATOM   356  C C   . MET A 1 47  ? 7.81549   -1.35885  74.33157 1.000 40.35363 ? 49  MET A C   1 
ATOM   357  O O   . MET A 1 47  ? 8.27012   -0.96333  73.25143 1.000 39.81792 ? 49  MET A O   1 
ATOM   358  C CB  . MET A 1 47  ? 5.42360   -2.08479  74.09995 1.000 44.74979 ? 49  MET A CB  1 
ATOM   359  C CG  . MET A 1 47  ? 4.52306   -3.23819  73.63439 1.000 51.44156 ? 49  MET A CG  1 
ATOM   360  S SD  . MET A 1 47  ? 2.82726   -2.85314  73.11732 1.000 63.44538 ? 49  MET A SD  1 
ATOM   361  C CE  . MET A 1 47  ? 2.31204   -4.43690  72.41639 1.000 51.02642 ? 49  MET A CE  1 
ATOM   362  N N   . LEU A 1 48  ? 8.14119   -0.77612  75.48445 1.000 40.67300 ? 50  LEU A N   1 
ATOM   363  C CA  . LEU A 1 48  ? 8.93461   0.44954   75.45320 1.000 42.10388 ? 50  LEU A CA  1 
ATOM   364  C C   . LEU A 1 48  ? 10.36006  0.17550   74.99150 1.000 45.47732 ? 50  LEU A C   1 
ATOM   365  O O   . LEU A 1 48  ? 10.90020  0.91573   74.15921 1.000 44.24469 ? 50  LEU A O   1 
ATOM   366  C CB  . LEU A 1 48  ? 8.92849   1.13544   76.82044 1.000 45.01548 ? 50  LEU A CB  1 
ATOM   367  C CG  . LEU A 1 48  ? 8.81863   2.66226   76.69022 1.000 45.82482 ? 50  LEU A CG  1 
ATOM   368  C CD1 . LEU A 1 48  ? 7.39677   3.03880   76.28208 1.000 42.45438 ? 50  LEU A CD1 1 
ATOM   369  C CD2 . LEU A 1 48  ? 9.23945   3.39741   77.96228 1.000 48.93587 ? 50  LEU A CD2 1 
ATOM   370  N N   . ASN A 1 49  ? 10.98002  -0.88878  75.50094 1.000 42.59572 ? 51  ASN A N   1 
ATOM   371  C CA  . ASN A 1 49  ? 12.33672  -1.26361  75.09688 1.000 45.04929 ? 51  ASN A CA  1 
ATOM   372  C C   . ASN A 1 49  ? 12.48870  -2.77654  75.12752 1.000 40.57891 ? 51  ASN A C   1 
ATOM   373  O O   . ASN A 1 49  ? 13.13042  -3.34293  76.02349 1.000 44.26930 ? 51  ASN A O   1 
ATOM   374  C CB  . ASN A 1 49  ? 13.38913  -0.59813  75.98176 1.000 48.00372 ? 51  ASN A CB  1 
ATOM   375  C CG  . ASN A 1 49  ? 14.64593  -0.27339  75.20833 1.000 54.77643 ? 51  ASN A CG  1 
ATOM   376  O OD1 . ASN A 1 49  ? 15.71189  -0.82768  75.47328 1.000 51.46343 ? 51  ASN A OD1 1 
ATOM   377  N ND2 . ASN A 1 49  ? 14.51615  0.60259   74.20768 1.000 57.94353 ? 51  ASN A ND2 1 
ATOM   378  N N   . PRO A 1 50  ? 11.92816  -3.46611  74.13702 1.000 35.17330 ? 52  PRO A N   1 
ATOM   379  C CA  . PRO A 1 50  ? 11.95502  -4.93444  74.14269 1.000 35.51244 ? 52  PRO A CA  1 
ATOM   380  C C   . PRO A 1 50  ? 13.33954  -5.48813  73.83525 1.000 36.36900 ? 52  PRO A C   1 
ATOM   381  O O   . PRO A 1 50  ? 14.08471  -4.94792  73.01900 1.000 39.54293 ? 52  PRO A O   1 
ATOM   382  C CB  . PRO A 1 50  ? 10.95684  -5.30512  73.03990 1.000 37.07109 ? 52  PRO A CB  1 
ATOM   383  C CG  . PRO A 1 50  ? 10.95587  -4.08280  72.10604 1.000 34.91455 ? 52  PRO A CG  1 
ATOM   384  C CD  . PRO A 1 50  ? 11.24758  -2.89544  72.95269 1.000 36.92431 ? 52  PRO A CD  1 
ATOM   385  N N   . ASN A 1 51  ? 13.68656  -6.57938  74.50355 1.000 36.81212 ? 53  ASN A N   1 
ATOM   386  C CA  . ASN A 1 51  ? 14.84239  -7.39197  74.11975 1.000 32.79305 ? 53  ASN A CA  1 
ATOM   387  C C   . ASN A 1 51  ? 14.28442  -8.63509  73.42168 1.000 30.88245 ? 53  ASN A C   1 
ATOM   388  O O   . ASN A 1 51  ? 13.86796  -9.60034  74.07240 1.000 29.77977 ? 53  ASN A O   1 
ATOM   389  C CB  . ASN A 1 51  ? 15.69603  -7.72417  75.34305 1.000 31.73498 ? 53  ASN A CB  1 
ATOM   390  C CG  . ASN A 1 51  ? 16.97425  -8.45291  74.98781 1.000 37.49575 ? 53  ASN A CG  1 
ATOM   391  O OD1 . ASN A 1 51  ? 16.96599  -9.40813  74.19869 1.000 38.46752 ? 53  ASN A OD1 1 
ATOM   392  N ND2 . ASN A 1 51  ? 18.08157  -8.02492  75.58077 1.000 41.40807 ? 53  ASN A ND2 1 
ATOM   393  N N   . TYR A 1 52  ? 14.24861  -8.60845  72.09007 1.000 28.59406 ? 54  TYR A N   1 
ATOM   394  C CA  . TYR A 1 52  ? 13.49623  -9.64973  71.39504 1.000 29.64111 ? 54  TYR A CA  1 
ATOM   395  C C   . TYR A 1 52  ? 14.16102  -11.01142 71.50156 1.000 30.72163 ? 54  TYR A C   1 
ATOM   396  O O   . TYR A 1 52  ? 13.45951  -12.02495 71.55029 1.000 29.07177 ? 54  TYR A O   1 
ATOM   397  C CB  . TYR A 1 52  ? 13.29867  -9.28900  69.93162 1.000 29.73460 ? 54  TYR A CB  1 
ATOM   398  C CG  . TYR A 1 52  ? 12.17824  -8.30132  69.72686 1.000 29.52693 ? 54  TYR A CG  1 
ATOM   399  C CD1 . TYR A 1 52  ? 10.85055  -8.70272  69.82805 1.000 29.87410 ? 54  TYR A CD1 1 
ATOM   400  C CD2 . TYR A 1 52  ? 12.44641  -6.96606  69.45942 1.000 32.86306 ? 54  TYR A CD2 1 
ATOM   401  C CE1 . TYR A 1 52  ? 9.81539   -7.79288  69.64271 1.000 34.92495 ? 54  TYR A CE1 1 
ATOM   402  C CE2 . TYR A 1 52  ? 11.41784  -6.04246  69.27081 1.000 32.22397 ? 54  TYR A CE2 1 
ATOM   403  C CZ  . TYR A 1 52  ? 10.10635  -6.46908  69.35637 1.000 30.24363 ? 54  TYR A CZ  1 
ATOM   404  O OH  . TYR A 1 52  ? 9.07745   -5.57943  69.18025 1.000 31.78108 ? 54  TYR A OH  1 
ATOM   405  N N   . GLU A 1 53  ? 15.49646  -11.06626 71.49677 1.000 31.43676 ? 55  GLU A N   1 
ATOM   406  C CA  . GLU A 1 53  ? 16.16758  -12.34983 71.69369 1.000 39.02380 ? 55  GLU A CA  1 
ATOM   407  C C   . GLU A 1 53  ? 15.71220  -12.99361 72.99271 1.000 38.13499 ? 55  GLU A C   1 
ATOM   408  O O   . GLU A 1 53  ? 15.29135  -14.15779 73.00555 1.000 36.33883 ? 55  GLU A O   1 
ATOM   409  C CB  . GLU A 1 53  ? 17.69077  -12.17280 71.67213 1.000 37.58443 ? 55  GLU A CB  1 
ATOM   410  C CG  . GLU A 1 53  ? 18.25305  -12.11270 70.25000 1.000 49.59190 ? 55  GLU A CG  1 
ATOM   411  C CD  . GLU A 1 53  ? 19.77680  -12.01889 70.18574 1.000 56.25339 ? 55  GLU A CD  1 
ATOM   412  O OE1 . GLU A 1 53  ? 20.43903  -12.08388 71.24485 1.000 57.36616 ? 55  GLU A OE1 1 
ATOM   413  O OE2 . GLU A 1 53  ? 20.31309  -11.87116 69.06127 1.000 60.85807 ? 55  GLU A OE2 1 
ATOM   414  N N   . ASP A 1 54  ? 15.74356  -12.23184 74.09343 1.000 33.30217 ? 56  ASP A N   1 
ATOM   415  C CA  . ASP A 1 54  ? 15.32673  -12.77737 75.37700 1.000 34.91196 ? 56  ASP A CA  1 
ATOM   416  C C   . ASP A 1 54  ? 13.84587  -13.13610 75.37478 1.000 36.55523 ? 56  ASP A C   1 
ATOM   417  O O   . ASP A 1 54  ? 13.44669  -14.16323 75.93109 1.000 34.26437 ? 56  ASP A O   1 
ATOM   418  C CB  . ASP A 1 54  ? 15.63559  -11.78012 76.49253 1.000 36.67451 ? 56  ASP A CB  1 
ATOM   419  C CG  . ASP A 1 54  ? 17.11112  -11.78274 76.87669 1.000 47.12133 ? 56  ASP A CG  1 
ATOM   420  O OD1 . ASP A 1 54  ? 17.94960  -12.26669 76.07899 1.000 44.33568 ? 56  ASP A OD1 1 
ATOM   421  O OD2 . ASP A 1 54  ? 17.44877  -11.30472 77.97681 1.000 57.30339 ? 56  ASP A OD2 1 
ATOM   422  N N   . LEU A 1 55  ? 13.00859  -12.28376 74.78054 1.000 34.28317 ? 57  LEU A N   1 
ATOM   423  C CA  . LEU A 1 55  ? 11.58023  -12.57428 74.73361 1.000 33.84203 ? 57  LEU A CA  1 
ATOM   424  C C   . LEU A 1 55  ? 11.30646  -13.83726 73.93576 1.000 33.18625 ? 57  LEU A C   1 
ATOM   425  O O   . LEU A 1 55  ? 10.40276  -14.60598 74.27969 1.000 33.99906 ? 57  LEU A O   1 
ATOM   426  C CB  . LEU A 1 55  ? 10.81518  -11.39958 74.12155 1.000 29.34885 ? 57  LEU A CB  1 
ATOM   427  C CG  . LEU A 1 55  ? 10.84148  -10.14071 74.97061 1.000 37.97220 ? 57  LEU A CG  1 
ATOM   428  C CD1 . LEU A 1 55  ? 10.11328  -8.99469  74.26067 1.000 35.72919 ? 57  LEU A CD1 1 
ATOM   429  C CD2 . LEU A 1 55  ? 10.25595  -10.42774 76.36084 1.000 39.79497 ? 57  LEU A CD2 1 
ATOM   430  N N   . LEU A 1 56  ? 12.07065  -14.06813 72.86011 1.000 29.16712 ? 58  LEU A N   1 
ATOM   431  C CA  . LEU A 1 56  ? 11.82360  -15.25488 72.04470 1.000 33.30408 ? 58  LEU A CA  1 
ATOM   432  C C   . LEU A 1 56  ? 12.29365  -16.52709 72.74191 1.000 35.46156 ? 58  LEU A C   1 
ATOM   433  O O   . LEU A 1 56  ? 11.66650  -17.58509 72.57785 1.000 35.75316 ? 58  LEU A O   1 
ATOM   434  C CB  . LEU A 1 56  ? 12.48923  -15.11323 70.67320 1.000 36.00667 ? 58  LEU A CB  1 
ATOM   435  C CG  . LEU A 1 56  ? 11.90873  -16.09397 69.65045 1.000 32.65689 ? 58  LEU A CG  1 
ATOM   436  C CD1 . LEU A 1 56  ? 10.37476  -16.06714 69.69904 1.000 31.13269 ? 58  LEU A CD1 1 
ATOM   437  C CD2 . LEU A 1 56  ? 12.41520  -15.82625 68.23040 1.000 36.21134 ? 58  LEU A CD2 1 
ATOM   438  N N   . ILE A 1 57  ? 13.38363  -16.43941 73.52050 1.000 35.48038 ? 59  ILE A N   1 
ATOM   439  C CA  . ILE A 1 57  ? 13.83137  -17.56091 74.35270 1.000 35.09550 ? 59  ILE A CA  1 
ATOM   440  C C   . ILE A 1 57  ? 12.70412  -18.03888 75.25005 1.000 35.67044 ? 59  ILE A C   1 
ATOM   441  O O   . ILE A 1 57  ? 12.48499  -19.24361 75.41921 1.000 37.43948 ? 59  ILE A O   1 
ATOM   442  C CB  . ILE A 1 57  ? 15.05870  -17.15290 75.19745 1.000 35.68594 ? 59  ILE A CB  1 
ATOM   443  C CG1 . ILE A 1 57  ? 16.30056  -16.91668 74.32244 1.000 34.17362 ? 59  ILE A CG1 1 
ATOM   444  C CG2 . ILE A 1 57  ? 15.31869  -18.15221 76.32505 1.000 34.29801 ? 59  ILE A CG2 1 
ATOM   445  C CD1 . ILE A 1 57  ? 16.33921  -17.76670 73.11085 1.000 39.12378 ? 59  ILE A CD1 1 
ATOM   446  N N   . ARG A 1 58  ? 11.97149  -17.10219 75.84521 1.000 35.97235 ? 60  ARG A N   1 
ATOM   447  C CA  . ARG A 1 58  ? 10.92173  -17.48899 76.77316 1.000 38.44442 ? 60  ARG A CA  1 
ATOM   448  C C   . ARG A 1 58  ? 9.72791   -18.13972 76.08265 1.000 42.56799 ? 60  ARG A C   1 
ATOM   449  O O   . ARG A 1 58  ? 8.93975   -18.81067 76.75738 1.000 45.51431 ? 60  ARG A O   1 
ATOM   450  C CB  . ARG A 1 58  ? 10.46844  -16.27497 77.58409 1.000 41.61433 ? 60  ARG A CB  1 
ATOM   451  C CG  . ARG A 1 58  ? 11.59468  -15.55889 78.32200 1.000 44.98423 ? 60  ARG A CG  1 
ATOM   452  C CD  . ARG A 1 58  ? 11.00920  -14.45628 79.20617 1.000 53.29729 ? 60  ARG A CD  1 
ATOM   453  N NE  . ARG A 1 58  ? 11.87230  -13.27855 79.34220 1.000 60.71461 ? 60  ARG A NE  1 
ATOM   454  C CZ  . ARG A 1 58  ? 12.96767  -13.23442 80.09618 1.000 61.76138 ? 60  ARG A CZ  1 
ATOM   455  N NH1 . ARG A 1 58  ? 13.68443  -12.11078 80.16973 1.000 59.67977 ? 60  ARG A NH1 1 
ATOM   456  N NH2 . ARG A 1 58  ? 13.34573  -14.31372 80.77836 1.000 61.55122 ? 60  ARG A NH2 1 
ATOM   457  N N   . LYS A 1 59  ? 9.58190   -17.99026 74.76521 1.000 41.27284 ? 61  LYS A N   1 
ATOM   458  C CA  . LYS A 1 59  ? 8.43157   -18.57781 74.08310 1.000 41.07883 ? 61  LYS A CA  1 
ATOM   459  C C   . LYS A 1 59  ? 8.67485   -20.03748 73.72643 1.000 40.85961 ? 61  LYS A C   1 
ATOM   460  O O   . LYS A 1 59  ? 9.80106   -20.45887 73.43282 1.000 39.99821 ? 61  LYS A O   1 
ATOM   461  C CB  . LYS A 1 59  ? 8.08842   -17.80062 72.80871 1.000 38.49508 ? 61  LYS A CB  1 
ATOM   462  C CG  . LYS A 1 59  ? 7.46792   -16.41733 73.06171 1.000 39.07306 ? 61  LYS A CG  1 
ATOM   463  C CD  . LYS A 1 59  ? 6.23178   -16.50680 73.93731 1.000 40.90954 ? 61  LYS A CD  1 
ATOM   464  C CE  . LYS A 1 59  ? 5.76958   -15.11159 74.34784 1.000 44.28434 ? 61  LYS A CE  1 
ATOM   465  N NZ  . LYS A 1 59  ? 4.61338   -15.14162 75.28761 1.000 50.93855 ? 61  LYS A NZ  1 
ATOM   466  N N   . SER A 1 60  ? 7.59380   -20.80966 73.75941 1.000 37.87959 ? 62  SER A N   1 
ATOM   467  C CA  . SER A 1 60  ? 7.55611   -22.16759 73.24596 1.000 41.83596 ? 62  SER A CA  1 
ATOM   468  C C   . SER A 1 60  ? 6.63196   -22.21311 72.03719 1.000 39.62478 ? 62  SER A C   1 
ATOM   469  O O   . SER A 1 60  ? 5.81068   -21.31663 71.82690 1.000 39.03650 ? 62  SER A O   1 
ATOM   470  C CB  . SER A 1 60  ? 7.06042   -23.16219 74.30518 1.000 42.84531 ? 62  SER A CB  1 
ATOM   471  O OG  . SER A 1 60  ? 7.49851   -22.82414 75.60848 1.000 48.77765 ? 62  SER A OG  1 
ATOM   472  N N   . ASN A 1 61  ? 6.76926   -23.28252 71.25019 1.000 38.08492 ? 63  ASN A N   1 
ATOM   473  C CA  . ASN A 1 61  ? 5.93463   -23.45746 70.06460 1.000 38.23794 ? 63  ASN A CA  1 
ATOM   474  C C   . ASN A 1 61  ? 4.45896   -23.35020 70.40177 1.000 41.59374 ? 63  ASN A C   1 
ATOM   475  O O   . ASN A 1 61  ? 3.66964   -22.80987 69.61512 1.000 42.44413 ? 63  ASN A O   1 
ATOM   476  C CB  . ASN A 1 61  ? 6.22515   -24.81309 69.42492 1.000 38.74418 ? 63  ASN A CB  1 
ATOM   477  C CG  . ASN A 1 61  ? 7.58018   -24.85894 68.81421 1.000 37.96465 ? 63  ASN A CG  1 
ATOM   478  O OD1 . ASN A 1 61  ? 8.14051   -23.81861 68.47727 1.000 39.24075 ? 63  ASN A OD1 1 
ATOM   479  N ND2 . ASN A 1 61  ? 8.13689   -26.04952 68.68040 1.000 37.94435 ? 63  ASN A ND2 1 
ATOM   480  N N   . HIS A 1 62  ? 4.06373   -23.87142 71.56294 1.000 40.08507 ? 64  HIS A N   1 
ATOM   481  C CA  . HIS A 1 62  ? 2.66589   -23.85566 71.96517 1.000 41.88631 ? 64  HIS A CA  1 
ATOM   482  C C   . HIS A 1 62  ? 2.20276   -22.49141 72.45735 1.000 42.78107 ? 64  HIS A C   1 
ATOM   483  O O   . HIS A 1 62  ? 1.01631   -22.33625 72.76388 1.000 41.30525 ? 64  HIS A O   1 
ATOM   484  C CB  . HIS A 1 62  ? 2.41291   -24.90446 73.04604 1.000 42.83957 ? 64  HIS A CB  1 
ATOM   485  C CG  . HIS A 1 62  ? 3.27510   -24.74592 74.25167 1.000 45.59406 ? 64  HIS A CG  1 
ATOM   486  N ND1 . HIS A 1 62  ? 2.97905   -23.85965 75.26369 1.000 46.86154 ? 64  HIS A ND1 1 
ATOM   487  C CD2 . HIS A 1 62  ? 4.43332   -25.35347 74.60452 1.000 46.00917 ? 64  HIS A CD2 1 
ATOM   488  C CE1 . HIS A 1 62  ? 3.91778   -23.92815 76.19183 1.000 46.68775 ? 64  HIS A CE1 1 
ATOM   489  N NE2 . HIS A 1 62  ? 4.81130   -24.82700 75.81500 1.000 52.92376 ? 64  HIS A NE2 1 
ATOM   490  N N   . ASN A 1 63  ? 3.08797   -21.50112 72.54309 1.000 41.37729 ? 65  ASN A N   1 
ATOM   491  C CA  . ASN A 1 63  ? 2.62304   -20.14651 72.81322 1.000 43.03753 ? 65  ASN A CA  1 
ATOM   492  C C   . ASN A 1 63  ? 2.16271   -19.41287 71.55358 1.000 39.80884 ? 65  ASN A C   1 
ATOM   493  O O   . ASN A 1 63  ? 1.70475   -18.26740 71.66022 1.000 44.32317 ? 65  ASN A O   1 
ATOM   494  C CB  . ASN A 1 63  ? 3.71437   -19.33933 73.51427 1.000 40.92731 ? 65  ASN A CB  1 
ATOM   495  C CG  . ASN A 1 63  ? 4.06256   -19.89539 74.88297 1.000 44.69115 ? 65  ASN A CG  1 
ATOM   496  O OD1 . ASN A 1 63  ? 5.16267   -20.39796 75.08763 1.000 47.59983 ? 65  ASN A OD1 1 
ATOM   497  N ND2 . ASN A 1 63  ? 3.11794   -19.82919 75.81898 1.000 42.84168 ? 65  ASN A ND2 1 
ATOM   498  N N   . PHE A 1 64  ? 2.24843   -20.04435 70.38251 1.000 37.10080 ? 66  PHE A N   1 
ATOM   499  C CA  . PHE A 1 64  ? 1.86723   -19.43987 69.10295 1.000 39.36011 ? 66  PHE A CA  1 
ATOM   500  C C   . PHE A 1 64  ? 0.67038   -20.19039 68.53204 1.000 42.69532 ? 66  PHE A C   1 
ATOM   501  O O   . PHE A 1 64  ? 0.80223   -21.34497 68.10882 1.000 45.54113 ? 66  PHE A O   1 
ATOM   502  C CB  . PHE A 1 64  ? 3.01941   -19.48545 68.10264 1.000 36.73383 ? 66  PHE A CB  1 
ATOM   503  C CG  . PHE A 1 64  ? 4.21123   -18.69382 68.51393 1.000 37.88341 ? 66  PHE A CG  1 
ATOM   504  C CD1 . PHE A 1 64  ? 4.18873   -17.30982 68.46452 1.000 37.13793 ? 66  PHE A CD1 1 
ATOM   505  C CD2 . PHE A 1 64  ? 5.36390   -19.33623 68.94023 1.000 35.85212 ? 66  PHE A CD2 1 
ATOM   506  C CE1 . PHE A 1 64  ? 5.29749   -16.56572 68.84666 1.000 34.38810 ? 66  PHE A CE1 1 
ATOM   507  C CE2 . PHE A 1 64  ? 6.46965   -18.60520 69.31642 1.000 41.06377 ? 66  PHE A CE2 1 
ATOM   508  C CZ  . PHE A 1 64  ? 6.43468   -17.21154 69.26975 1.000 39.45112 ? 66  PHE A CZ  1 
ATOM   509  N N   . LEU A 1 65  ? -0.48273  -19.53435 68.48598 1.000 37.73670 ? 67  LEU A N   1 
ATOM   510  C CA  . LEU A 1 65  ? -1.67390  -20.11072 67.87613 1.000 43.48868 ? 67  LEU A CA  1 
ATOM   511  C C   . LEU A 1 65  ? -1.83752  -19.53150 66.46738 1.000 42.80461 ? 67  LEU A C   1 
ATOM   512  O O   . LEU A 1 65  ? -2.01963  -18.31746 66.30460 1.000 35.76930 ? 67  LEU A O   1 
ATOM   513  C CB  . LEU A 1 65  ? -2.90253  -19.84090 68.74718 1.000 40.01163 ? 67  LEU A CB  1 
ATOM   514  C CG  . LEU A 1 65  ? -4.26172  -19.90574 68.04856 1.000 47.61985 ? 67  LEU A CG  1 
ATOM   515  C CD1 . LEU A 1 65  ? -4.66094  -21.33225 67.60842 1.000 49.85024 ? 67  LEU A CD1 1 
ATOM   516  C CD2 . LEU A 1 65  ? -5.35435  -19.23055 68.88615 1.000 46.72274 ? 67  LEU A CD2 1 
ATOM   517  N N   . VAL A 1 66  ? -1.74336  -20.39544 65.45775 1.000 40.16608 ? 68  VAL A N   1 
ATOM   518  C CA  . VAL A 1 66  ? -1.84695  -20.01217 64.05009 1.000 40.18651 ? 68  VAL A CA  1 
ATOM   519  C C   . VAL A 1 66  ? -3.06959  -20.70227 63.46093 1.000 40.49078 ? 68  VAL A C   1 
ATOM   520  O O   . VAL A 1 66  ? -3.19024  -21.93229 63.51749 1.000 37.69320 ? 68  VAL A O   1 
ATOM   521  C CB  . VAL A 1 66  ? -0.58262  -20.38076 63.25249 1.000 36.92182 ? 68  VAL A CB  1 
ATOM   522  C CG1 . VAL A 1 66  ? -0.72755  -19.96193 61.77662 1.000 34.28394 ? 68  VAL A CG1 1 
ATOM   523  C CG2 . VAL A 1 66  ? 0.65659   -19.79416 63.91863 1.000 35.00331 ? 68  VAL A CG2 1 
ATOM   524  N N   . GLN A 1 67  ? -3.95917  -19.91591 62.88063 1.000 40.59632 ? 69  GLN A N   1 
ATOM   525  C CA  . GLN A 1 67  ? -5.22691  -20.39964 62.36702 1.000 43.49048 ? 69  GLN A CA  1 
ATOM   526  C C   . GLN A 1 67  ? -5.31788  -20.06365 60.88217 1.000 41.42528 ? 69  GLN A C   1 
ATOM   527  O O   . GLN A 1 67  ? -5.11613  -18.90935 60.48834 1.000 39.79944 ? 69  GLN A O   1 
ATOM   528  C CB  . GLN A 1 67  ? -6.37264  -19.75184 63.14825 1.000 48.85288 ? 69  GLN A CB  1 
ATOM   529  C CG  . GLN A 1 67  ? -7.50452  -20.67534 63.55429 1.000 57.76695 ? 69  GLN A CG  1 
ATOM   530  C CD  . GLN A 1 67  ? -8.49260  -19.97207 64.46656 1.000 66.57613 ? 69  GLN A CD  1 
ATOM   531  O OE1 . GLN A 1 67  ? -8.12577  -19.47604 65.53788 1.000 62.56444 ? 69  GLN A OE1 1 
ATOM   532  N NE2 . GLN A 1 67  ? -9.74963  -19.89051 64.02816 1.000 67.36687 ? 69  GLN A NE2 1 
ATOM   533  N N   . ALA A 1 68  ? -5.61457  -21.06417 60.06193 1.000 45.00701 ? 70  ALA A N   1 
ATOM   534  C CA  . ALA A 1 68  ? -5.83540  -20.88473 58.63078 1.000 44.03949 ? 70  ALA A CA  1 
ATOM   535  C C   . ALA A 1 68  ? -7.32234  -21.04186 58.36920 1.000 46.54250 ? 70  ALA A C   1 
ATOM   536  O O   . ALA A 1 68  ? -7.86875  -22.13369 58.53610 1.000 49.88704 ? 70  ALA A O   1 
ATOM   537  C CB  . ALA A 1 68  ? -5.03707  -21.89181 57.80409 1.000 40.84354 ? 70  ALA A CB  1 
ATOM   538  N N   . GLY A 1 69  ? -7.97412  -19.96052 57.96489 1.000 52.53730 ? 71  GLY A N   1 
ATOM   539  C CA  . GLY A 1 69  ? -9.41871  -19.97642 57.96033 1.000 53.32414 ? 71  GLY A CA  1 
ATOM   540  C C   . GLY A 1 69  ? -9.89989  -20.36701 59.33929 1.000 58.69084 ? 71  GLY A C   1 
ATOM   541  O O   . GLY A 1 69  ? -9.91145  -19.53640 60.25046 1.000 66.01675 ? 71  GLY A O   1 
ATOM   542  N N   . ASN A 1 70  ? -10.24947 -21.64036 59.52391 1.000 60.52239 ? 72  ASN A N   1 
ATOM   543  C CA  . ASN A 1 70  ? -10.63065 -22.14181 60.83963 1.000 61.17228 ? 72  ASN A CA  1 
ATOM   544  C C   . ASN A 1 70  ? -9.97299  -23.48834 61.14287 1.000 62.94566 ? 72  ASN A C   1 
ATOM   545  O O   . ASN A 1 70  ? -10.51596 -24.29387 61.90700 1.000 61.46684 ? 72  ASN A O   1 
ATOM   546  C CB  . ASN A 1 70  ? -12.15733 -22.22440 60.98561 1.000 64.70057 ? 72  ASN A CB  1 
ATOM   547  C CG  . ASN A 1 70  ? -12.81503 -23.17960 59.98531 1.000 67.85490 ? 72  ASN A CG  1 
ATOM   548  O OD1 . ASN A 1 70  ? -12.23268 -24.18843 59.58032 1.000 63.89003 ? 72  ASN A OD1 1 
ATOM   549  N ND2 . ASN A 1 70  ? -14.05152 -22.86501 59.59984 1.000 71.15469 ? 72  ASN A ND2 1 
ATOM   550  N N   . VAL A 1 71  ? -8.80311  -23.75154 60.55897 1.000 60.02068 ? 73  VAL A N   1 
ATOM   551  C CA  . VAL A 1 71  ? -7.98452  -24.90578 60.92014 1.000 54.80195 ? 73  VAL A CA  1 
ATOM   552  C C   . VAL A 1 71  ? -6.76713  -24.42021 61.70393 1.000 57.44778 ? 73  VAL A C   1 
ATOM   553  O O   . VAL A 1 71  ? -6.14532  -23.40734 61.35431 1.000 48.32332 ? 73  VAL A O   1 
ATOM   554  C CB  . VAL A 1 71  ? -7.55899  -25.74333 59.69253 1.000 56.94049 ? 73  VAL A CB  1 
ATOM   555  C CG1 . VAL A 1 71  ? -7.00553  -24.88682 58.59267 1.000 56.48827 ? 73  VAL A CG1 1 
ATOM   556  C CG2 . VAL A 1 71  ? -6.52106  -26.76523 60.08409 1.000 54.58673 ? 73  VAL A CG2 1 
ATOM   557  N N   . GLN A 1 72  ? -6.44272  -25.13981 62.77972 1.000 52.55804 ? 74  GLN A N   1 
ATOM   558  C CA  . GLN A 1 72  ? -5.29287  -24.82138 63.61476 1.000 52.13207 ? 74  GLN A CA  1 
ATOM   559  C C   . GLN A 1 72  ? -4.05422  -25.49720 63.04316 1.000 47.17240 ? 74  GLN A C   1 
ATOM   560  O O   . GLN A 1 72  ? -4.01946  -26.72461 62.89747 1.000 50.41121 ? 74  GLN A O   1 
ATOM   561  C CB  . GLN A 1 72  ? -5.53027  -25.26221 65.05946 1.000 52.99046 ? 74  GLN A CB  1 
ATOM   562  C CG  . GLN A 1 72  ? -6.40147  -24.31339 65.85374 1.000 60.71781 ? 74  GLN A CG  1 
ATOM   563  C CD  . GLN A 1 72  ? -7.13655  -24.99997 66.98996 1.000 68.82907 ? 74  GLN A CD  1 
ATOM   564  O OE1 . GLN A 1 72  ? -7.75684  -26.04474 66.79963 1.000 75.18505 ? 74  GLN A OE1 1 
ATOM   565  N NE2 . GLN A 1 72  ? -7.08263  -24.40451 68.17894 1.000 67.25490 ? 74  GLN A NE2 1 
ATOM   566  N N   . LEU A 1 73  ? -3.04893  -24.69668 62.70567 1.000 43.32260 ? 75  LEU A N   1 
ATOM   567  C CA  . LEU A 1 73  ? -1.77455  -25.22179 62.24600 1.000 43.96318 ? 75  LEU A CA  1 
ATOM   568  C C   . LEU A 1 73  ? -0.88365  -25.46302 63.44983 1.000 51.55705 ? 75  LEU A C   1 
ATOM   569  O O   . LEU A 1 73  ? -0.89606  -24.68653 64.40736 1.000 49.52369 ? 75  LEU A O   1 
ATOM   570  C CB  . LEU A 1 73  ? -1.09768  -24.25598 61.27670 1.000 41.61722 ? 75  LEU A CB  1 
ATOM   571  C CG  . LEU A 1 73  ? -1.94322  -23.89959 60.05860 1.000 46.85221 ? 75  LEU A CG  1 
ATOM   572  C CD1 . LEU A 1 73  ? -1.17376  -22.97452 59.11798 1.000 41.28447 ? 75  LEU A CD1 1 
ATOM   573  C CD2 . LEU A 1 73  ? -2.36319  -25.17372 59.35242 1.000 40.16710 ? 75  LEU A CD2 1 
ATOM   574  N N   . ARG A 1 74  ? -0.12643  -26.55146 63.41978 1.000 45.44137 ? 76  ARG A N   1 
ATOM   575  C CA  . ARG A 1 74  ? 0.73481   -26.88152 64.54253 1.000 44.06394 ? 76  ARG A CA  1 
ATOM   576  C C   . ARG A 1 74  ? 2.10147   -26.24412 64.32264 1.000 39.54742 ? 76  ARG A C   1 
ATOM   577  O O   . ARG A 1 74  ? 2.79137   -26.56341 63.34668 1.000 38.65987 ? 76  ARG A O   1 
ATOM   578  C CB  . ARG A 1 74  ? 0.85510   -28.39468 64.69989 1.000 47.12843 ? 76  ARG A CB  1 
ATOM   579  C CG  . ARG A 1 74  ? 1.78115   -28.80035 65.81543 1.000 49.76474 ? 76  ARG A CG  1 
ATOM   580  C CD  . ARG A 1 74  ? 1.32744   -30.08858 66.46695 1.000 52.74122 ? 76  ARG A CD  1 
ATOM   581  N NE  . ARG A 1 74  ? 2.45986   -30.79688 67.04132 1.000 59.27508 ? 76  ARG A NE  1 
ATOM   582  C CZ  . ARG A 1 74  ? 3.04225   -31.84747 66.47307 1.000 63.99273 ? 76  ARG A CZ  1 
ATOM   583  N NH1 . ARG A 1 74  ? 2.58453   -32.32254 65.32107 1.000 62.72603 ? 76  ARG A NH1 1 
ATOM   584  N NH2 . ARG A 1 74  ? 4.07647   -32.43058 67.06042 1.000 63.84279 ? 76  ARG A NH2 1 
ATOM   585  N N   . VAL A 1 75  ? 2.49203   -25.34285 65.21747 1.000 38.98444 ? 77  VAL A N   1 
ATOM   586  C CA  . VAL A 1 75  ? 3.82707   -24.75845 65.15023 1.000 37.06842 ? 77  VAL A CA  1 
ATOM   587  C C   . VAL A 1 75  ? 4.81841   -25.77879 65.69363 1.000 37.83364 ? 77  VAL A C   1 
ATOM   588  O O   . VAL A 1 75  ? 4.66501   -26.26746 66.81944 1.000 41.03268 ? 77  VAL A O   1 
ATOM   589  C CB  . VAL A 1 75  ? 3.89828   -23.43902 65.92959 1.000 38.85722 ? 77  VAL A CB  1 
ATOM   590  C CG1 . VAL A 1 75  ? 5.32476   -22.89293 65.92394 1.000 32.75402 ? 77  VAL A CG1 1 
ATOM   591  C CG2 . VAL A 1 75  ? 2.93036   -22.42458 65.33201 1.000 36.70629 ? 77  VAL A CG2 1 
ATOM   592  N N   . ILE A 1 76  ? 5.83129   -26.11016 64.89115 1.000 39.79124 ? 78  ILE A N   1 
ATOM   593  C CA  . ILE A 1 76  ? 6.84734   -27.08404 65.26161 1.000 39.14619 ? 78  ILE A CA  1 
ATOM   594  C C   . ILE A 1 76  ? 8.23630   -26.46379 65.33958 1.000 40.18080 ? 78  ILE A C   1 
ATOM   595  O O   . ILE A 1 76  ? 9.21481   -27.17438 65.55585 1.000 41.80120 ? 78  ILE A O   1 
ATOM   596  C CB  . ILE A 1 76  ? 6.83188   -28.29264 64.30206 1.000 39.15881 ? 78  ILE A CB  1 
ATOM   597  C CG1 . ILE A 1 76  ? 7.30804   -27.88278 62.90054 1.000 40.11110 ? 78  ILE A CG1 1 
ATOM   598  C CG2 . ILE A 1 76  ? 5.44407   -28.92589 64.26949 1.000 36.07838 ? 78  ILE A CG2 1 
ATOM   599  C CD1 . ILE A 1 76  ? 7.43008   -29.05432 61.90143 1.000 33.57507 ? 78  ILE A CD1 1 
ATOM   600  N N   . GLY A 1 77  ? 8.33446   -25.14968 65.18579 1.000 38.16843 ? 79  GLY A N   1 
ATOM   601  C CA  . GLY A 1 77  ? 9.59693   -24.45532 65.29276 1.000 32.87396 ? 79  GLY A CA  1 
ATOM   602  C C   . GLY A 1 77  ? 9.34841   -22.97140 65.17665 1.000 36.31447 ? 79  GLY A C   1 
ATOM   603  O O   . GLY A 1 77  ? 8.32851   -22.52622 64.63160 1.000 37.09960 ? 79  GLY A O   1 
ATOM   604  N N   . HIS A 1 78  ? 10.27769  -22.19638 65.72877 1.000 33.66267 ? 80  HIS A N   1 
ATOM   605  C CA  . HIS A 1 78  ? 10.14927  -20.74999 65.65215 1.000 36.46400 ? 80  HIS A CA  1 
ATOM   606  C C   . HIS A 1 78  ? 11.51684  -20.09955 65.71398 1.000 42.15141 ? 80  HIS A C   1 
ATOM   607  O O   . HIS A 1 78  ? 12.39044  -20.52796 66.46927 1.000 40.24038 ? 80  HIS A O   1 
ATOM   608  C CB  . HIS A 1 78  ? 9.24832   -20.18773 66.75711 1.000 33.89580 ? 80  HIS A CB  1 
ATOM   609  C CG  . HIS A 1 78  ? 9.77599   -20.38438 68.14106 1.000 40.57378 ? 80  HIS A CG  1 
ATOM   610  N ND1 . HIS A 1 78  ? 9.44808   -21.47825 68.91577 1.000 43.17010 ? 80  HIS A ND1 1 
ATOM   611  C CD2 . HIS A 1 78  ? 10.60290  -19.62135 68.89349 1.000 39.74431 ? 80  HIS A CD2 1 
ATOM   612  C CE1 . HIS A 1 78  ? 10.06600  -21.38574 70.08181 1.000 45.47210 ? 80  HIS A CE1 1 
ATOM   613  N NE2 . HIS A 1 78  ? 10.76707  -20.26425 70.09446 1.000 44.84167 ? 80  HIS A NE2 1 
ATOM   614  N N   . SER A 1 79  ? 11.69144  -19.06763 64.90394 1.000 32.32773 ? 81  SER A N   1 
ATOM   615  C CA  . SER A 1 79  ? 12.96591  -18.39249 64.81044 1.000 36.18661 ? 81  SER A CA  1 
ATOM   616  C C   . SER A 1 79  ? 12.71098  -16.96937 64.34415 1.000 37.29403 ? 81  SER A C   1 
ATOM   617  O O   . SER A 1 79  ? 11.62071  -16.63071 63.87814 1.000 33.03372 ? 81  SER A O   1 
ATOM   618  C CB  . SER A 1 79  ? 13.90991  -19.14236 63.87015 1.000 33.96693 ? 81  SER A CB  1 
ATOM   619  O OG  . SER A 1 79  ? 13.68198  -18.81815 62.52050 1.000 37.35798 ? 81  SER A OG  1 
ATOM   620  N N   . MET A 1 80  ? 13.73811  -16.14183 64.45215 1.000 36.36301 ? 82  MET A N   1 
ATOM   621  C CA  . MET A 1 80  ? 13.62124  -14.72045 64.18709 1.000 33.30964 ? 82  MET A CA  1 
ATOM   622  C C   . MET A 1 80  ? 14.64592  -14.33798 63.13299 1.000 35.02499 ? 82  MET A C   1 
ATOM   623  O O   . MET A 1 80  ? 15.82876  -14.65666 63.28107 1.000 40.92547 ? 82  MET A O   1 
ATOM   624  C CB  . MET A 1 80  ? 13.83965  -13.94605 65.48571 1.000 37.27104 ? 82  MET A CB  1 
ATOM   625  C CG  . MET A 1 80  ? 13.62226  -12.47477 65.40732 1.000 39.11651 ? 82  MET A CG  1 
ATOM   626  S SD  . MET A 1 80  ? 13.65710  -11.80568 67.08376 1.000 43.39876 ? 82  MET A SD  1 
ATOM   627  C CE  . MET A 1 80  ? 15.27576  -12.29436 67.67136 1.000 36.26040 ? 82  MET A CE  1 
ATOM   628  N N   . GLN A 1 81  ? 14.19276  -13.66388 62.07257 1.000 29.01803 ? 83  GLN A N   1 
ATOM   629  C CA  . GLN A 1 81  ? 15.06453  -13.13109 61.02901 1.000 29.89127 ? 83  GLN A CA  1 
ATOM   630  C C   . GLN A 1 81  ? 14.87337  -11.61752 61.00288 1.000 32.84894 ? 83  GLN A C   1 
ATOM   631  O O   . GLN A 1 81  ? 13.83491  -11.12734 60.54386 1.000 28.16746 ? 83  GLN A O   1 
ATOM   632  C CB  . GLN A 1 81  ? 14.74002  -13.75974 59.67767 1.000 35.93258 ? 83  GLN A CB  1 
ATOM   633  C CG  . GLN A 1 81  ? 15.59510  -13.28304 58.50553 1.000 40.62510 ? 83  GLN A CG  1 
ATOM   634  C CD  . GLN A 1 81  ? 15.26821  -14.03625 57.21527 1.000 49.10485 ? 83  GLN A CD  1 
ATOM   635  O OE1 . GLN A 1 81  ? 14.15476  -14.55483 57.04299 1.000 49.92083 ? 83  GLN A OE1 1 
ATOM   636  N NE2 . GLN A 1 81  ? 16.23918  -14.10238 56.30395 1.000 54.65282 ? 83  GLN A NE2 1 
ATOM   637  N N   . ASN A 1 82  ? 15.85502  -10.88320 61.52483 1.000 26.86355 ? 84  ASN A N   1 
ATOM   638  C CA  . ASN A 1 82  ? 15.70424  -9.44838  61.72656 1.000 29.91547 ? 84  ASN A CA  1 
ATOM   639  C C   . ASN A 1 82  ? 14.38832  -9.20605  62.46608 1.000 27.09746 ? 84  ASN A C   1 
ATOM   640  O O   . ASN A 1 82  ? 14.19167  -9.76209  63.55148 1.000 28.91800 ? 84  ASN A O   1 
ATOM   641  C CB  . ASN A 1 82  ? 15.80542  -8.74138  60.37467 1.000 29.77828 ? 84  ASN A CB  1 
ATOM   642  C CG  . ASN A 1 82  ? 17.12752  -9.04530  59.67090 1.000 32.17021 ? 84  ASN A CG  1 
ATOM   643  O OD1 . ASN A 1 82  ? 18.19435  -8.82457  60.24355 1.000 34.76614 ? 84  ASN A OD1 1 
ATOM   644  N ND2 . ASN A 1 82  ? 17.06319  -9.58340  58.45072 1.000 30.50624 ? 84  ASN A ND2 1 
ATOM   645  N N   . CYS A 1 83  ? 13.44836  -8.46011  61.88130 1.000 26.57604 ? 85  CYS A N   1 
ATOM   646  C CA  . CYS A 1 83  ? 12.21371  -8.10799  62.58485 1.000 28.04537 ? 85  CYS A CA  1 
ATOM   647  C C   . CYS A 1 83  ? 11.00395  -8.97779  62.22790 1.000 29.00716 ? 85  CYS A C   1 
ATOM   648  O O   . CYS A 1 83  ? 9.88460   -8.64071  62.62906 1.000 26.19778 ? 85  CYS A O   1 
ATOM   649  C CB  . CYS A 1 83  ? 11.86488  -6.64062  62.33583 1.000 25.45606 ? 85  CYS A CB  1 
ATOM   650  S SG  . CYS A 1 83  ? 13.08292  -5.50854  63.03734 1.000 31.43827 ? 85  CYS A SG  1 
ATOM   651  N N   . VAL A 1 84  ? 11.17849  -10.08387 61.50666 1.000 27.23555 ? 86  VAL A N   1 
ATOM   652  C CA  . VAL A 1 84  ? 10.06913  -10.98838 61.24040 1.000 30.02468 ? 86  VAL A CA  1 
ATOM   653  C C   . VAL A 1 84  ? 10.28370  -12.29196 61.99822 1.000 32.91852 ? 86  VAL A C   1 
ATOM   654  O O   . VAL A 1 84  ? 11.40397  -12.81275 62.08437 1.000 29.64809 ? 86  VAL A O   1 
ATOM   655  C CB  . VAL A 1 84  ? 9.82330   -11.26627 59.73639 1.000 36.14096 ? 86  VAL A CB  1 
ATOM   656  C CG1 . VAL A 1 84  ? 9.46343   -9.96077  58.99517 1.000 29.73663 ? 86  VAL A CG1 1 
ATOM   657  C CG2 . VAL A 1 84  ? 10.98785  -12.00023 59.07734 1.000 36.67874 ? 86  VAL A CG2 1 
ATOM   658  N N   . LEU A 1 85  ? 9.18918   -12.80207 62.55639 1.000 30.11727 ? 87  LEU A N   1 
ATOM   659  C CA  . LEU A 1 85  ? 9.12780   -14.12852 63.13507 1.000 33.41144 ? 87  LEU A CA  1 
ATOM   660  C C   . LEU A 1 85  ? 8.80896   -15.14800 62.04978 1.000 34.94105 ? 87  LEU A C   1 
ATOM   661  O O   . LEU A 1 85  ? 7.93893   -14.92205 61.20802 1.000 31.47964 ? 87  LEU A O   1 
ATOM   662  C CB  . LEU A 1 85  ? 8.05653   -14.15140 64.21968 1.000 34.27666 ? 87  LEU A CB  1 
ATOM   663  C CG  . LEU A 1 85  ? 7.99882   -15.28326 65.22483 1.000 37.77551 ? 87  LEU A CG  1 
ATOM   664  C CD1 . LEU A 1 85  ? 9.30691   -15.35513 65.95472 1.000 36.07547 ? 87  LEU A CD1 1 
ATOM   665  C CD2 . LEU A 1 85  ? 6.85760   -14.97462 66.18126 1.000 39.50441 ? 87  LEU A CD2 1 
ATOM   666  N N   . LYS A 1 86  ? 9.52200   -16.27150 62.06383 1.000 32.09240 ? 88  LYS A N   1 
ATOM   667  C CA  . LYS A 1 86  ? 9.24084   -17.38711 61.17029 1.000 31.38036 ? 88  LYS A CA  1 
ATOM   668  C C   . LYS A 1 86  ? 8.77327   -18.56642 62.02293 1.000 36.57416 ? 88  LYS A C   1 
ATOM   669  O O   . LYS A 1 86  ? 9.55073   -19.12588 62.80582 1.000 32.92989 ? 88  LYS A O   1 
ATOM   670  C CB  . LYS A 1 86  ? 10.46887  -17.73335 60.33519 1.000 32.32593 ? 88  LYS A CB  1 
ATOM   671  C CG  . LYS A 1 86  ? 10.99561  -16.53168 59.57694 1.000 33.94707 ? 88  LYS A CG  1 
ATOM   672  C CD  . LYS A 1 86  ? 11.90387  -16.90378 58.41709 1.000 41.53369 ? 88  LYS A CD  1 
ATOM   673  C CE  . LYS A 1 86  ? 13.28193  -17.30184 58.91125 1.000 47.94041 ? 88  LYS A CE  1 
ATOM   674  N NZ  . LYS A 1 86  ? 14.30455  -17.21355 57.82342 1.000 54.26127 ? 88  LYS A NZ  1 
ATOM   675  N N   . LEU A 1 87  ? 7.49535   -18.90936 61.89086 1.000 29.58996 ? 89  LEU A N   1 
ATOM   676  C CA  . LEU A 1 87  ? 6.87981   -20.01380 62.61065 1.000 30.67330 ? 89  LEU A CA  1 
ATOM   677  C C   . LEU A 1 87  ? 6.79706   -21.18642 61.64269 1.000 35.30585 ? 89  LEU A C   1 
ATOM   678  O O   . LEU A 1 87  ? 6.05994   -21.13470 60.65068 1.000 35.59219 ? 89  LEU A O   1 
ATOM   679  C CB  . LEU A 1 87  ? 5.50076   -19.62002 63.13257 1.000 28.08954 ? 89  LEU A CB  1 
ATOM   680  C CG  . LEU A 1 87  ? 5.47036   -18.35488 63.98948 1.000 30.32523 ? 89  LEU A CG  1 
ATOM   681  C CD1 . LEU A 1 87  ? 4.03992   -18.03922 64.38138 1.000 32.06247 ? 89  LEU A CD1 1 
ATOM   682  C CD2 . LEU A 1 87  ? 6.33100   -18.54194 65.21644 1.000 31.00654 ? 89  LEU A CD2 1 
ATOM   683  N N   . LYS A 1 88  ? 7.57975   -22.22290 61.90525 1.000 34.89328 ? 90  LYS A N   1 
ATOM   684  C CA  . LYS A 1 88  ? 7.52039   -23.42584 61.08941 1.000 37.06314 ? 90  LYS A CA  1 
ATOM   685  C C   . LYS A 1 88  ? 6.29698   -24.24213 61.49579 1.000 36.08613 ? 90  LYS A C   1 
ATOM   686  O O   . LYS A 1 88  ? 6.09081   -24.52644 62.67921 1.000 34.87441 ? 90  LYS A O   1 
ATOM   687  C CB  . LYS A 1 88  ? 8.80405   -24.23588 61.26208 1.000 39.05975 ? 90  LYS A CB  1 
ATOM   688  C CG  . LYS A 1 88  ? 8.95256   -25.38227 60.30948 1.000 39.43619 ? 90  LYS A CG  1 
ATOM   689  C CD  . LYS A 1 88  ? 9.98878   -25.05218 59.23931 1.000 45.15306 ? 90  LYS A CD  1 
ATOM   690  C CE  . LYS A 1 88  ? 10.46968  -26.30898 58.51848 1.000 52.12342 ? 90  LYS A CE  1 
ATOM   691  N NZ  . LYS A 1 88  ? 11.35724  -27.15899 59.38056 1.000 54.89543 ? 90  LYS A NZ  1 
ATOM   692  N N   . VAL A 1 89  ? 5.46749   -24.59807 60.52821 1.000 33.78441 ? 91  VAL A N   1 
ATOM   693  C CA  . VAL A 1 89  ? 4.27931   -25.37788 60.82355 1.000 36.83007 ? 91  VAL A CA  1 
ATOM   694  C C   . VAL A 1 89  ? 4.40821   -26.74843 60.16121 1.000 36.06770 ? 91  VAL A C   1 
ATOM   695  O O   . VAL A 1 89  ? 5.22777   -26.96390 59.26198 1.000 35.42106 ? 91  VAL A O   1 
ATOM   696  C CB  . VAL A 1 89  ? 2.99592   -24.64045 60.39050 1.000 34.65520 ? 91  VAL A CB  1 
ATOM   697  C CG1 . VAL A 1 89  ? 2.87957   -23.34590 61.17217 1.000 37.18625 ? 91  VAL A CG1 1 
ATOM   698  C CG2 . VAL A 1 89  ? 3.02055   -24.35317 58.90148 1.000 36.22915 ? 91  VAL A CG2 1 
ATOM   699  N N   . ASP A 1 90  ? 3.59820   -27.69075 60.63050 1.000 36.89555 ? 92  ASP A N   1 
ATOM   700  C CA  . ASP A 1 90  ? 3.73631   -29.07147 60.17689 1.000 42.10317 ? 92  ASP A CA  1 
ATOM   701  C C   . ASP A 1 90  ? 3.00312   -29.36599 58.86794 1.000 42.45738 ? 92  ASP A C   1 
ATOM   702  O O   . ASP A 1 90  ? 2.99899   -30.51858 58.43810 1.000 46.47070 ? 92  ASP A O   1 
ATOM   703  C CB  . ASP A 1 90  ? 3.26439   -30.04695 61.26920 1.000 40.74920 ? 92  ASP A CB  1 
ATOM   704  C CG  . ASP A 1 90  ? 1.76506   -30.02494 61.47581 1.000 46.50975 ? 92  ASP A CG  1 
ATOM   705  O OD1 . ASP A 1 90  ? 1.08755   -29.08488 60.99778 1.000 49.27193 ? 92  ASP A OD1 1 
ATOM   706  O OD2 . ASP A 1 90  ? 1.25327   -30.95921 62.12978 1.000 56.14432 ? 92  ASP A OD2 1 
ATOM   707  N N   . THR A 1 91  ? 2.38612   -28.37569 58.22143 1.000 43.62010 ? 93  THR A N   1 
ATOM   708  C CA  . THR A 1 91  ? 1.77840   -28.56618 56.90776 1.000 42.34657 ? 93  THR A CA  1 
ATOM   709  C C   . THR A 1 91  ? 2.23772   -27.46031 55.96515 1.000 42.20166 ? 93  THR A C   1 
ATOM   710  O O   . THR A 1 91  ? 2.45051   -26.31716 56.38627 1.000 37.21882 ? 93  THR A O   1 
ATOM   711  C CB  . THR A 1 91  ? 0.23101   -28.57991 56.97340 1.000 39.84142 ? 93  THR A CB  1 
ATOM   712  O OG1 . THR A 1 91  ? -0.26310  -27.23917 57.03820 1.000 55.58866 ? 93  THR A OG1 1 
ATOM   713  C CG2 . THR A 1 91  ? -0.26649  -29.34374 58.18561 1.000 43.47132 ? 93  THR A CG2 1 
ATOM   714  N N   . ALA A 1 92  ? 2.40915   -27.80709 54.69088 1.000 43.36738 ? 94  ALA A N   1 
ATOM   715  C CA  . ALA A 1 92  ? 2.65522   -26.79524 53.67718 1.000 36.08461 ? 94  ALA A CA  1 
ATOM   716  C C   . ALA A 1 92  ? 1.32338   -26.22514 53.20935 1.000 40.84046 ? 94  ALA A C   1 
ATOM   717  O O   . ALA A 1 92  ? 0.31662   -26.93816 53.14179 1.000 35.77420 ? 94  ALA A O   1 
ATOM   718  C CB  . ALA A 1 92  ? 3.43439   -27.37594 52.49892 1.000 34.59925 ? 94  ALA A CB  1 
ATOM   719  N N   . ASN A 1 93  ? 1.30406   -24.92055 52.94059 1.000 36.38936 ? 95  ASN A N   1 
ATOM   720  C CA  . ASN A 1 93  ? 0.08729   -24.29964 52.42584 1.000 37.56060 ? 95  ASN A CA  1 
ATOM   721  C C   . ASN A 1 93  ? -0.14391  -24.85106 51.02616 1.000 34.87254 ? 95  ASN A C   1 
ATOM   722  O O   . ASN A 1 93  ? 0.70909   -24.64861 50.15139 1.000 35.34354 ? 95  ASN A O   1 
ATOM   723  C CB  . ASN A 1 93  ? 0.23414   -22.77076 52.41168 1.000 34.84190 ? 95  ASN A CB  1 
ATOM   724  C CG  . ASN A 1 93  ? -1.03762  -22.04252 51.99787 1.000 36.32782 ? 95  ASN A CG  1 
ATOM   725  O OD1 . ASN A 1 93  ? -2.04156  -22.64998 51.63751 1.000 35.85863 ? 95  ASN A OD1 1 
ATOM   726  N ND2 . ASN A 1 93  ? -0.98710  -20.70668 52.04755 1.000 36.79647 ? 95  ASN A ND2 1 
ATOM   727  N N   . PRO A 1 94  ? -1.23773  -25.58525 50.77680 1.000 35.91124 ? 96  PRO A N   1 
ATOM   728  C CA  . PRO A 1 94  ? -1.49086  -26.07311 49.40858 1.000 36.29491 ? 96  PRO A CA  1 
ATOM   729  C C   . PRO A 1 94  ? -1.80653  -24.95590 48.42453 1.000 39.99285 ? 96  PRO A C   1 
ATOM   730  O O   . PRO A 1 94  ? -1.74355  -25.18696 47.21129 1.000 39.76125 ? 96  PRO A O   1 
ATOM   731  C CB  . PRO A 1 94  ? -2.69468  -27.00200 49.58250 1.000 35.76738 ? 96  PRO A CB  1 
ATOM   732  C CG  . PRO A 1 94  ? -3.42795  -26.44063 50.73476 1.000 35.64151 ? 96  PRO A CG  1 
ATOM   733  C CD  . PRO A 1 94  ? -2.38776  -25.83023 51.66665 1.000 32.96497 ? 96  PRO A CD  1 
ATOM   734  N N   . LYS A 1 95  ? -2.15763  -23.76243 48.90363 1.000 37.83165 ? 97  LYS A N   1 
ATOM   735  C CA  . LYS A 1 95  ? -2.42724  -22.62023 48.04195 1.000 35.78897 ? 97  LYS A CA  1 
ATOM   736  C C   . LYS A 1 95  ? -1.21856  -21.70495 47.88427 1.000 37.47533 ? 97  LYS A C   1 
ATOM   737  O O   . LYS A 1 95  ? -1.37467  -20.56647 47.43818 1.000 39.54907 ? 97  LYS A O   1 
ATOM   738  C CB  . LYS A 1 95  ? -3.61103  -21.82234 48.58621 1.000 38.43101 ? 97  LYS A CB  1 
ATOM   739  C CG  . LYS A 1 95  ? -4.90756  -22.60776 48.66720 1.000 41.17375 ? 97  LYS A CG  1 
ATOM   740  C CD  . LYS A 1 95  ? -6.07161  -21.70905 49.08518 1.000 47.54116 ? 97  LYS A CD  1 
ATOM   741  C CE  . LYS A 1 95  ? -7.10907  -22.48797 49.88349 1.000 54.00464 ? 97  LYS A CE  1 
ATOM   742  N NZ  . LYS A 1 95  ? -7.96861  -21.58028 50.69342 1.000 59.60438 ? 97  LYS A NZ  1 
ATOM   743  N N   . THR A 1 96  ? -0.03109  -22.15578 48.26879 1.000 36.00756 ? 98  THR A N   1 
ATOM   744  C CA  . THR A 1 96  ? 1.17383   -21.37738 48.04938 1.000 33.67520 ? 98  THR A CA  1 
ATOM   745  C C   . THR A 1 96  ? 1.30925   -21.06154 46.56553 1.000 38.83393 ? 98  THR A C   1 
ATOM   746  O O   . THR A 1 96  ? 1.29125   -21.98808 45.74115 1.000 38.21134 ? 98  THR A O   1 
ATOM   747  C CB  . THR A 1 96  ? 2.40728   -22.13452 48.53714 1.000 34.70319 ? 98  THR A CB  1 
ATOM   748  O OG1 . THR A 1 96  ? 2.27523   -22.41523 49.93219 1.000 36.96754 ? 98  THR A OG1 1 
ATOM   749  C CG2 . THR A 1 96  ? 3.66210   -21.32297 48.30356 1.000 34.08120 ? 98  THR A CG2 1 
ATOM   750  N N   . PRO A 1 97  ? 1.41204   -19.79596 46.17952 1.000 36.41407 ? 99  PRO A N   1 
ATOM   751  C CA  . PRO A 1 97  ? 1.73548   -19.45053 44.79549 1.000 35.24355 ? 99  PRO A CA  1 
ATOM   752  C C   . PRO A 1 97  ? 3.23987   -19.46224 44.58944 1.000 35.57899 ? 99  PRO A C   1 
ATOM   753  O O   . PRO A 1 97  ? 4.02657   -19.60834 45.53179 1.000 35.97740 ? 99  PRO A O   1 
ATOM   754  C CB  . PRO A 1 97  ? 1.17095   -18.02091 44.65370 1.000 38.66088 ? 99  PRO A CB  1 
ATOM   755  C CG  . PRO A 1 97  ? 1.34658   -17.43287 46.01552 1.000 36.82288 ? 99  PRO A CG  1 
ATOM   756  C CD  . PRO A 1 97  ? 1.22246   -18.59742 47.01215 1.000 36.55832 ? 99  PRO A CD  1 
ATOM   757  N N   . LYS A 1 98  ? 3.63382   -19.30059 43.32759 1.000 32.56345 ? 100 LYS A N   1 
ATOM   758  C CA  . LYS A 1 98  ? 5.01484   -18.94826 43.00490 1.000 38.17462 ? 100 LYS A CA  1 
ATOM   759  C C   . LYS A 1 98  ? 5.30161   -17.52901 43.49481 1.000 39.00834 ? 100 LYS A C   1 
ATOM   760  O O   . LYS A 1 98  ? 4.50386   -16.61853 43.25656 1.000 36.85726 ? 100 LYS A O   1 
ATOM   761  C CB  . LYS A 1 98  ? 5.24815   -19.04433 41.49193 1.000 40.92362 ? 100 LYS A CB  1 
ATOM   762  C CG  . LYS A 1 98  ? 6.58849   -18.49026 41.00463 1.000 48.21412 ? 100 LYS A CG  1 
ATOM   763  C CD  . LYS A 1 98  ? 7.69112   -19.55503 41.00101 1.000 53.76222 ? 100 LYS A CD  1 
ATOM   764  C CE  . LYS A 1 98  ? 8.94494   -19.07978 41.72495 1.000 51.43174 ? 100 LYS A CE  1 
ATOM   765  N NZ  . LYS A 1 98  ? 8.82238   -19.27496 43.21524 1.000 50.06434 ? 100 LYS A NZ  1 
ATOM   766  N N   . TYR A 1 99  ? 6.42729   -17.33071 44.18410 1.000 36.21414 ? 101 TYR A N   1 
ATOM   767  C CA  . TYR A 1 99  ? 6.67318   -16.04337 44.82571 1.000 35.73411 ? 101 TYR A CA  1 
ATOM   768  C C   . TYR A 1 99  ? 8.16599   -15.74854 44.88419 1.000 37.48778 ? 101 TYR A C   1 
ATOM   769  O O   . TYR A 1 99  ? 8.99962   -16.64741 44.78093 1.000 32.97038 ? 101 TYR A O   1 
ATOM   770  C CB  . TYR A 1 99  ? 6.06793   -16.00414 46.23724 1.000 34.59479 ? 101 TYR A CB  1 
ATOM   771  C CG  . TYR A 1 99  ? 6.77508   -16.89322 47.24007 1.000 33.23602 ? 101 TYR A CG  1 
ATOM   772  C CD1 . TYR A 1 99  ? 6.46161   -18.24748 47.34506 1.000 35.34680 ? 101 TYR A CD1 1 
ATOM   773  C CD2 . TYR A 1 99  ? 7.77095   -16.38553 48.06268 1.000 32.50235 ? 101 TYR A CD2 1 
ATOM   774  C CE1 . TYR A 1 99  ? 7.11953   -19.07958 48.26226 1.000 37.31107 ? 101 TYR A CE1 1 
ATOM   775  C CE2 . TYR A 1 99  ? 8.44159   -17.20673 48.97332 1.000 35.86350 ? 101 TYR A CE2 1 
ATOM   776  C CZ  . TYR A 1 99  ? 8.10723   -18.54265 49.06622 1.000 37.99408 ? 101 TYR A CZ  1 
ATOM   777  O OH  . TYR A 1 99  ? 8.76312   -19.32406 49.97457 1.000 45.05095 ? 101 TYR A OH  1 
ATOM   778  N N   . LYS A 1 100 ? 8.49179   -14.46160 45.03565 1.000 31.95428 ? 102 LYS A N   1 
ATOM   779  C CA  . LYS A 1 100 ? 9.82586   -14.00944 45.41526 1.000 37.41349 ? 102 LYS A CA  1 
ATOM   780  C C   . LYS A 1 100 ? 9.67726   -12.94664 46.48857 1.000 33.67728 ? 102 LYS A C   1 
ATOM   781  O O   . LYS A 1 100 ? 8.62580   -12.31283 46.61392 1.000 31.96995 ? 102 LYS A O   1 
ATOM   782  C CB  . LYS A 1 100 ? 10.65205  -13.39258 44.26341 1.000 39.46405 ? 102 LYS A CB  1 
ATOM   783  C CG  . LYS A 1 100 ? 10.23723  -13.74712 42.84427 1.000 44.86527 ? 102 LYS A CG  1 
ATOM   784  C CD  . LYS A 1 100 ? 11.02255  -12.92890 41.79892 1.000 48.43584 ? 102 LYS A CD  1 
ATOM   785  C CE  . LYS A 1 100 ? 10.84929  -13.51810 40.38830 1.000 57.64915 ? 102 LYS A CE  1 
ATOM   786  N NZ  . LYS A 1 100 ? 12.00163  -13.25866 39.46183 1.000 54.30020 ? 102 LYS A NZ  1 
ATOM   787  N N   . PHE A 1 101 ? 10.75385  -12.75249 47.24710 1.000 30.96593 ? 103 PHE A N   1 
ATOM   788  C CA  . PHE A 1 101 ? 10.85236  -11.68543 48.24015 1.000 35.33387 ? 103 PHE A CA  1 
ATOM   789  C C   . PHE A 1 101 ? 11.68491  -10.56086 47.63675 1.000 36.62331 ? 103 PHE A C   1 
ATOM   790  O O   . PHE A 1 101 ? 12.83440  -10.78332 47.24304 1.000 37.08372 ? 103 PHE A O   1 
ATOM   791  C CB  . PHE A 1 101 ? 11.50276  -12.17836 49.53681 1.000 35.88872 ? 103 PHE A CB  1 
ATOM   792  C CG  . PHE A 1 101 ? 10.61455  -13.04639 50.39566 1.000 30.98039 ? 103 PHE A CG  1 
ATOM   793  C CD1 . PHE A 1 101 ? 9.25674   -13.13338 50.16021 1.000 30.09240 ? 103 PHE A CD1 1 
ATOM   794  C CD2 . PHE A 1 101 ? 11.15562  -13.76644 51.45863 1.000 31.39748 ? 103 PHE A CD2 1 
ATOM   795  C CE1 . PHE A 1 101 ? 8.45274   -13.92841 50.95852 1.000 31.34397 ? 103 PHE A CE1 1 
ATOM   796  C CE2 . PHE A 1 101 ? 10.35490  -14.56942 52.26873 1.000 27.01550 ? 103 PHE A CE2 1 
ATOM   797  C CZ  . PHE A 1 101 ? 9.00542   -14.65150 52.01715 1.000 28.97168 ? 103 PHE A CZ  1 
ATOM   798  N N   . VAL A 1 102 ? 11.11742  -9.36137  47.55195 1.000 29.58087 ? 104 VAL A N   1 
ATOM   799  C CA  . VAL A 1 102 ? 11.82615  -8.25249  46.93049 1.000 31.26941 ? 104 VAL A CA  1 
ATOM   800  C C   . VAL A 1 102 ? 11.82504  -7.05972  47.86661 1.000 31.68801 ? 104 VAL A C   1 
ATOM   801  O O   . VAL A 1 102 ? 10.88928  -6.84987  48.64270 1.000 34.28975 ? 104 VAL A O   1 
ATOM   802  C CB  . VAL A 1 102 ? 11.21817  -7.87041  45.55665 1.000 34.17275 ? 104 VAL A CB  1 
ATOM   803  C CG1 . VAL A 1 102 ? 11.06223  -9.11850  44.68668 1.000 33.10556 ? 104 VAL A CG1 1 
ATOM   804  C CG2 . VAL A 1 102 ? 9.88509   -7.17114  45.72172 1.000 32.03279 ? 104 VAL A CG2 1 
ATOM   805  N N   . ARG A 1 103 ? 12.89038  -6.28027  47.79780 1.000 28.24000 ? 105 ARG A N   1 
ATOM   806  C CA  . ARG A 1 103 ? 12.97643  -5.02032  48.51457 1.000 32.49992 ? 105 ARG A CA  1 
ATOM   807  C C   . ARG A 1 103 ? 12.78806  -3.91828  47.49258 1.000 33.10678 ? 105 ARG A C   1 
ATOM   808  O O   . ARG A 1 103 ? 13.55150  -3.83834  46.52593 1.000 36.87114 ? 105 ARG A O   1 
ATOM   809  C CB  . ARG A 1 103 ? 14.31679  -4.87440  49.23462 1.000 33.60413 ? 105 ARG A CB  1 
ATOM   810  C CG  . ARG A 1 103 ? 14.38950  -3.62919  50.11357 1.000 33.33754 ? 105 ARG A CG  1 
ATOM   811  C CD  . ARG A 1 103 ? 15.57012  -3.68303  51.06431 1.000 33.67632 ? 105 ARG A CD  1 
ATOM   812  N NE  . ARG A 1 103 ? 15.66403  -2.47297  51.88483 1.000 34.31758 ? 105 ARG A NE  1 
ATOM   813  C CZ  . ARG A 1 103 ? 15.07489  -2.32371  53.06650 1.000 33.74731 ? 105 ARG A CZ  1 
ATOM   814  N NH1 . ARG A 1 103 ? 14.34896  -3.31550  53.57731 1.000 27.06774 ? 105 ARG A NH1 1 
ATOM   815  N NH2 . ARG A 1 103 ? 15.21143  -1.17731  53.73426 1.000 29.87201 ? 105 ARG A NH2 1 
ATOM   816  N N   . ILE A 1 104 ? 11.75983  -3.09464  47.67934 1.000 33.28005 ? 106 ILE A N   1 
ATOM   817  C CA  . ILE A 1 104 ? 11.48748  -2.04152  46.70681 1.000 35.56433 ? 106 ILE A CA  1 
ATOM   818  C C   . ILE A 1 104 ? 12.21081  -0.75842  47.07366 1.000 32.39402 ? 106 ILE A C   1 
ATOM   819  O O   . ILE A 1 104 ? 12.76281  -0.63442  48.16970 1.000 32.97475 ? 106 ILE A O   1 
ATOM   820  C CB  . ILE A 1 104 ? 9.97909   -1.78454  46.56461 1.000 36.04774 ? 106 ILE A CB  1 
ATOM   821  C CG1 . ILE A 1 104 ? 9.36619   -1.44552  47.92581 1.000 34.03465 ? 106 ILE A CG1 1 
ATOM   822  C CG2 . ILE A 1 104 ? 9.31436   -2.97890  45.88638 1.000 34.05305 ? 106 ILE A CG2 1 
ATOM   823  C CD1 . ILE A 1 104 ? 8.03087   -0.78090  47.81622 1.000 37.97535 ? 106 ILE A CD1 1 
ATOM   824  N N   . GLN A 1 105 ? 12.21005  0.20655   46.14941 1.000 33.17246 ? 107 GLN A N   1 
ATOM   825  C CA  . GLN A 1 105 ? 12.76851  1.55783   46.05314 1.000 38.33806 ? 107 GLN A CA  1 
ATOM   826  C C   . GLN A 1 105 ? 11.72959  2.61144   46.43250 1.000 34.24301 ? 107 GLN A C   1 
ATOM   827  O O   . GLN A 1 105 ? 10.54717  2.47290   46.08653 1.000 33.30344 ? 107 GLN A O   1 
ATOM   828  C CB  . GLN A 1 105 ? 13.25183  1.83804   44.62752 1.000 39.66939 ? 107 GLN A CB  1 
ATOM   829  C CG  . GLN A 1 105 ? 14.59287  1.23335   44.28042 1.000 40.67533 ? 107 GLN A CG  1 
ATOM   830  C CD  . GLN A 1 105 ? 15.66347  1.65760   45.25752 1.000 51.21032 ? 107 GLN A CD  1 
ATOM   831  O OE1 . GLN A 1 105 ? 15.80732  2.84581   45.56731 1.000 56.01130 ? 107 GLN A OE1 1 
ATOM   832  N NE2 . GLN A 1 105 ? 16.42486  0.68888   45.75714 1.000 58.22829 ? 107 GLN A NE2 1 
ATOM   833  N N   . PRO A 1 106 ? 12.12139  3.67099   47.13532 1.000 34.86044 ? 108 PRO A N   1 
ATOM   834  C CA  . PRO A 1 106 ? 11.19011  4.78546   47.36250 1.000 33.45698 ? 108 PRO A CA  1 
ATOM   835  C C   . PRO A 1 106 ? 10.64478  5.32790   46.04622 1.000 34.16989 ? 108 PRO A C   1 
ATOM   836  O O   . PRO A 1 106 ? 11.36177  5.44833   45.05023 1.000 32.13281 ? 108 PRO A O   1 
ATOM   837  C CB  . PRO A 1 106 ? 12.04065  5.82886   48.09212 1.000 39.11030 ? 108 PRO A CB  1 
ATOM   838  C CG  . PRO A 1 106 ? 13.45432  5.31070   48.07013 1.000 37.58159 ? 108 PRO A CG  1 
ATOM   839  C CD  . PRO A 1 106 ? 13.39423  3.84349   47.85029 1.000 39.72426 ? 108 PRO A CD  1 
ATOM   840  N N   . GLY A 1 107 ? 9.35184   5.64281   46.04209 1.000 33.36604 ? 109 GLY A N   1 
ATOM   841  C CA  . GLY A 1 107 ? 8.66553   6.02638   44.83001 1.000 29.33191 ? 109 GLY A CA  1 
ATOM   842  C C   . GLY A 1 107 ? 7.96873   4.89210   44.10726 1.000 34.56044 ? 109 GLY A C   1 
ATOM   843  O O   . GLY A 1 107 ? 7.05837   5.14929   43.31311 1.000 34.44810 ? 109 GLY A O   1 
ATOM   844  N N   . GLN A 1 108 ? 8.36177   3.64445   44.35239 1.000 30.65519 ? 110 GLN A N   1 
ATOM   845  C CA  . GLN A 1 108 ? 7.71230   2.52315   43.69925 1.000 30.35182 ? 110 GLN A CA  1 
ATOM   846  C C   . GLN A 1 108 ? 6.39079   2.21421   44.39664 1.000 31.87228 ? 110 GLN A C   1 
ATOM   847  O O   . GLN A 1 108 ? 6.20829   2.50014   45.58347 1.000 32.54338 ? 110 GLN A O   1 
ATOM   848  C CB  . GLN A 1 108 ? 8.63398   1.29474   43.69690 1.000 32.68886 ? 110 GLN A CB  1 
ATOM   849  C CG  . GLN A 1 108 ? 9.46304   1.18444   42.42064 1.000 39.68803 ? 110 GLN A CG  1 
ATOM   850  C CD  . GLN A 1 108 ? 10.72308  0.32331   42.54277 1.000 47.67187 ? 110 GLN A CD  1 
ATOM   851  O OE1 . GLN A 1 108 ? 10.89226  -0.45750  43.49104 1.000 42.51177 ? 110 GLN A OE1 1 
ATOM   852  N NE2 . GLN A 1 108 ? 11.61946  0.46709   41.56312 1.000 45.94849 ? 110 GLN A NE2 1 
ATOM   853  N N   . THR A 1 109 ? 5.46389   1.61972   43.65201 1.000 30.92490 ? 111 THR A N   1 
ATOM   854  C CA  . THR A 1 109 ? 4.14585   1.31592   44.18486 1.000 30.69152 ? 111 THR A CA  1 
ATOM   855  C C   . THR A 1 109 ? 3.94390   -0.18878  44.33321 1.000 29.90572 ? 111 THR A C   1 
ATOM   856  O O   . THR A 1 109 ? 4.69216   -1.01542  43.79178 1.000 27.17641 ? 111 THR A O   1 
ATOM   857  C CB  . THR A 1 109 ? 3.04745   1.91097   43.29946 1.000 33.30840 ? 111 THR A CB  1 
ATOM   858  O OG1 . THR A 1 109 ? 3.09602   1.30037   42.00800 1.000 30.73236 ? 111 THR A OG1 1 
ATOM   859  C CG2 . THR A 1 109 ? 3.23662   3.41960   43.17227 1.000 32.92609 ? 111 THR A CG2 1 
ATOM   860  N N   . PHE A 1 110 ? 2.89915   -0.53298  45.08522 1.000 27.71076 ? 112 PHE A N   1 
ATOM   861  C CA  . PHE A 1 110 ? 2.53698   -1.92796  45.31087 1.000 27.69217 ? 112 PHE A CA  1 
ATOM   862  C C   . PHE A 1 110 ? 1.09039   -1.97869  45.77554 1.000 28.28180 ? 112 PHE A C   1 
ATOM   863  O O   . PHE A 1 110 ? 0.49689   -0.95906  46.14651 1.000 29.67279 ? 112 PHE A O   1 
ATOM   864  C CB  . PHE A 1 110 ? 3.46737   -2.60960  46.33008 1.000 26.95655 ? 112 PHE A CB  1 
ATOM   865  C CG  . PHE A 1 110 ? 3.60062   -1.87292  47.65334 1.000 28.38090 ? 112 PHE A CG  1 
ATOM   866  C CD1 . PHE A 1 110 ? 2.74889   -2.15137  48.71363 1.000 25.94571 ? 112 PHE A CD1 1 
ATOM   867  C CD2 . PHE A 1 110 ? 4.58855   -0.92660  47.83603 1.000 30.48025 ? 112 PHE A CD2 1 
ATOM   868  C CE1 . PHE A 1 110 ? 2.86894   -1.50577  49.91673 1.000 28.54019 ? 112 PHE A CE1 1 
ATOM   869  C CE2 . PHE A 1 110 ? 4.71486   -0.26341  49.04404 1.000 33.33747 ? 112 PHE A CE2 1 
ATOM   870  C CZ  . PHE A 1 110 ? 3.85221   -0.55658  50.09048 1.000 34.87602 ? 112 PHE A CZ  1 
ATOM   871  N N   . SER A 1 111 ? 0.52552   -3.17316  45.72948 1.000 23.23202 ? 113 SER A N   1 
ATOM   872  C CA  . SER A 1 111 ? -0.82094  -3.39964  46.23062 1.000 26.07357 ? 113 SER A CA  1 
ATOM   873  C C   . SER A 1 111 ? -0.75380  -3.91583  47.65851 1.000 28.75049 ? 113 SER A C   1 
ATOM   874  O O   . SER A 1 111 ? 0.10615   -4.73326  47.99273 1.000 27.46310 ? 113 SER A O   1 
ATOM   875  C CB  . SER A 1 111 ? -1.56171  -4.41285  45.35907 1.000 27.83990 ? 113 SER A CB  1 
ATOM   876  O OG  . SER A 1 111 ? -1.87323  -3.86288  44.09889 1.000 30.23411 ? 113 SER A OG  1 
ATOM   877  N N   . VAL A 1 112 ? -1.69691  -3.47462  48.48223 1.000 24.97583 ? 114 VAL A N   1 
ATOM   878  C CA  . VAL A 1 112 ? -1.79757  -3.90233  49.86660 1.000 24.58980 ? 114 VAL A CA  1 
ATOM   879  C C   . VAL A 1 112 ? -3.06611  -4.71373  50.02531 1.000 25.96206 ? 114 VAL A C   1 
ATOM   880  O O   . VAL A 1 112 ? -4.14313  -4.28949  49.58303 1.000 27.13581 ? 114 VAL A O   1 
ATOM   881  C CB  . VAL A 1 112 ? -1.80439  -2.70578  50.83195 1.000 30.23102 ? 114 VAL A CB  1 
ATOM   882  C CG1 . VAL A 1 112 ? -2.05792  -3.20733  52.25247 1.000 28.55739 ? 114 VAL A CG1 1 
ATOM   883  C CG2 . VAL A 1 112 ? -0.48804  -1.97828  50.74974 1.000 28.64840 ? 114 VAL A CG2 1 
ATOM   884  N N   . LEU A 1 113 ? -2.93300  -5.89301  50.63162 1.000 25.87607 ? 115 LEU A N   1 
ATOM   885  C CA  . LEU A 1 113 ? -4.07662  -6.70026  51.01805 1.000 25.08159 ? 115 LEU A CA  1 
ATOM   886  C C   . LEU A 1 113 ? -4.24238  -6.51421  52.51900 1.000 30.14206 ? 115 LEU A C   1 
ATOM   887  O O   . LEU A 1 113 ? -3.54798  -7.15501  53.31922 1.000 27.38633 ? 115 LEU A O   1 
ATOM   888  C CB  . LEU A 1 113 ? -3.88299  -8.16435  50.63282 1.000 27.04703 ? 115 LEU A CB  1 
ATOM   889  C CG  . LEU A 1 113 ? -5.10755  -9.01043  51.02092 1.000 29.18590 ? 115 LEU A CG  1 
ATOM   890  C CD1 . LEU A 1 113 ? -6.37627  -8.53837  50.29121 1.000 32.20402 ? 115 LEU A CD1 1 
ATOM   891  C CD2 . LEU A 1 113 ? -4.84252  -10.50828 50.78920 1.000 27.82776 ? 115 LEU A CD2 1 
ATOM   892  N N   . ALA A 1 114 ? -5.15768  -5.62306  52.89455 1.000 26.43841 ? 116 ALA A N   1 
ATOM   893  C CA  . ALA A 1 114 ? -5.38492  -5.27864  54.29556 1.000 31.75850 ? 116 ALA A CA  1 
ATOM   894  C C   . ALA A 1 114 ? -6.20755  -6.37565  54.97484 1.000 31.67739 ? 116 ALA A C   1 
ATOM   895  O O   . ALA A 1 114 ? -7.29577  -6.72285  54.50197 1.000 29.01462 ? 116 ALA A O   1 
ATOM   896  C CB  . ALA A 1 114 ? -6.09059  -3.92802  54.39312 1.000 29.59632 ? 116 ALA A CB  1 
ATOM   897  N N   . CYS A 1 115 ? -5.68209  -6.92026  56.08133 1.000 27.98166 ? 117 CYS A N   1 
ATOM   898  C CA  . CYS A 1 115 ? -6.26290  -8.06912  56.76453 1.000 31.53039 ? 117 CYS A CA  1 
ATOM   899  C C   . CYS A 1 115 ? -6.41677  -7.78494  58.25033 1.000 29.90287 ? 117 CYS A C   1 
ATOM   900  O O   . CYS A 1 115 ? -5.65316  -7.00621  58.83193 1.000 28.13114 ? 117 CYS A O   1 
ATOM   901  C CB  . CYS A 1 115 ? -5.39957  -9.32650  56.60351 1.000 32.21974 ? 117 CYS A CB  1 
ATOM   902  S SG  . CYS A 1 115 ? -5.17414  -9.88747  54.90456 1.000 36.95846 ? 117 CYS A SG  1 
ATOM   903  N N   . TYR A 1 116 ? -7.41724  -8.43300  58.84922 1.000 30.50577 ? 118 TYR A N   1 
ATOM   904  C CA  . TYR A 1 116 ? -7.64974  -8.43511  60.29262 1.000 30.59447 ? 118 TYR A CA  1 
ATOM   905  C C   . TYR A 1 116 ? -8.03014  -9.84652  60.72037 1.000 33.43169 ? 118 TYR A C   1 
ATOM   906  O O   . TYR A 1 116 ? -8.86364  -10.48750 60.07057 1.000 28.69138 ? 118 TYR A O   1 
ATOM   907  C CB  . TYR A 1 116 ? -8.73864  -7.41920  60.66494 1.000 28.46693 ? 118 TYR A CB  1 
ATOM   908  C CG  . TYR A 1 116 ? -8.33128  -6.05446  60.19207 1.000 31.92994 ? 118 TYR A CG  1 
ATOM   909  C CD1 . TYR A 1 116 ? -7.51403  -5.25702  60.97181 1.000 29.83429 ? 118 TYR A CD1 1 
ATOM   910  C CD2 . TYR A 1 116 ? -8.70023  -5.58727  58.92370 1.000 36.00471 ? 118 TYR A CD2 1 
ATOM   911  C CE1 . TYR A 1 116 ? -7.09527  -4.02911  60.53107 1.000 28.55901 ? 118 TYR A CE1 1 
ATOM   912  C CE2 . TYR A 1 116 ? -8.28622  -4.33840  58.47016 1.000 32.79080 ? 118 TYR A CE2 1 
ATOM   913  C CZ  . TYR A 1 116 ? -7.47789  -3.56729  59.28034 1.000 31.94432 ? 118 TYR A CZ  1 
ATOM   914  O OH  . TYR A 1 116 ? -7.03141  -2.33269  58.86519 1.000 27.89628 ? 118 TYR A OH  1 
ATOM   915  N N   . ASN A 1 117 ? -7.38890  -10.33902 61.78945 1.000 34.08267 ? 119 ASN A N   1 
ATOM   916  C CA  . ASN A 1 117 ? -7.62664  -11.69110 62.30455 1.000 31.92043 ? 119 ASN A CA  1 
ATOM   917  C C   . ASN A 1 117 ? -7.39010  -12.74353 61.23402 1.000 33.83552 ? 119 ASN A C   1 
ATOM   918  O O   . ASN A 1 117 ? -8.09509  -13.74581 61.16463 1.000 34.48789 ? 119 ASN A O   1 
ATOM   919  C CB  . ASN A 1 117 ? -9.03556  -11.83685 62.87751 1.000 38.86416 ? 119 ASN A CB  1 
ATOM   920  C CG  . ASN A 1 117 ? -9.32544  -10.81276 63.92233 1.000 38.76856 ? 119 ASN A CG  1 
ATOM   921  O OD1 . ASN A 1 117 ? -8.58906  -10.69587 64.89484 1.000 45.04487 ? 119 ASN A OD1 1 
ATOM   922  N ND2 . ASN A 1 117 ? -10.38314 -10.02957 63.71874 1.000 44.87603 ? 119 ASN A ND2 1 
ATOM   923  N N   . GLY A 1 118 ? -6.40534  -12.49802 60.37823 1.000 32.04570 ? 120 GLY A N   1 
ATOM   924  C CA  . GLY A 1 118 ? -6.10219  -13.42562 59.32893 1.000 32.73290 ? 120 GLY A CA  1 
ATOM   925  C C   . GLY A 1 118 ? -7.04753  -13.43254 58.15519 1.000 31.73546 ? 120 GLY A C   1 
ATOM   926  O O   . GLY A 1 118 ? -6.85770  -14.24757 57.25876 1.000 36.75158 ? 120 GLY A O   1 
ATOM   927  N N   . SER A 1 119 ? -8.03821  -12.53504 58.10336 1.000 32.96203 ? 121 SER A N   1 
ATOM   928  C CA  . SER A 1 119 ? -8.99012  -12.53676 56.99574 1.000 34.04333 ? 121 SER A CA  1 
ATOM   929  C C   . SER A 1 119 ? -8.84448  -11.29276 56.13053 1.000 38.59345 ? 121 SER A C   1 
ATOM   930  O O   . SER A 1 119 ? -8.84963  -10.17078 56.65776 1.000 35.41604 ? 121 SER A O   1 
ATOM   931  C CB  . SER A 1 119 ? -10.42036 -12.61545 57.52194 1.000 38.57072 ? 121 SER A CB  1 
ATOM   932  O OG  . SER A 1 119 ? -10.61453 -13.81485 58.24435 1.000 50.01970 ? 121 SER A OG  1 
ATOM   933  N N   . PRO A 1 120 ? -8.72378  -11.44746 54.81046 1.000 38.98486 ? 122 PRO A N   1 
ATOM   934  C CA  . PRO A 1 120 ? -8.66909  -10.27182 53.92702 1.000 34.38413 ? 122 PRO A CA  1 
ATOM   935  C C   . PRO A 1 120 ? -9.89810  -9.39398  54.08706 1.000 37.43296 ? 122 PRO A C   1 
ATOM   936  O O   . PRO A 1 120 ? -11.02938 -9.87976  54.14429 1.000 36.96382 ? 122 PRO A O   1 
ATOM   937  C CB  . PRO A 1 120 ? -8.60710  -10.88529 52.52744 1.000 36.91959 ? 122 PRO A CB  1 
ATOM   938  C CG  . PRO A 1 120 ? -7.97956  -12.23956 52.74575 1.000 38.45829 ? 122 PRO A CG  1 
ATOM   939  C CD  . PRO A 1 120 ? -8.42744  -12.70351 54.10298 1.000 37.72253 ? 122 PRO A CD  1 
ATOM   940  N N   . SER A 1 121 ? -9.67501  -8.08840  54.16247 1.000 34.99601 ? 123 SER A N   1 
ATOM   941  C CA  . SER A 1 121 ? -10.79794 -7.16908  54.18950 1.000 33.57207 ? 123 SER A CA  1 
ATOM   942  C C   . SER A 1 121 ? -10.84352 -6.20894  53.01052 1.000 35.83153 ? 123 SER A C   1 
ATOM   943  O O   . SER A 1 121 ? -11.93676 -5.79406  52.62698 1.000 35.20354 ? 123 SER A O   1 
ATOM   944  C CB  . SER A 1 121 ? -10.80531 -6.36919  55.49788 1.000 35.01710 ? 123 SER A CB  1 
ATOM   945  O OG  . SER A 1 121 ? -9.67194  -5.54465  55.59079 1.000 41.94630 ? 123 SER A OG  1 
ATOM   946  N N   . GLY A 1 122 ? -9.70688  -5.85851  52.41849 1.000 33.76770 ? 124 GLY A N   1 
ATOM   947  C CA  . GLY A 1 122 ? -9.71674  -4.91476  51.30729 1.000 36.60024 ? 124 GLY A CA  1 
ATOM   948  C C   . GLY A 1 122 ? -8.37807  -4.90817  50.60399 1.000 32.37555 ? 124 GLY A C   1 
ATOM   949  O O   . GLY A 1 122 ? -7.38409  -5.43941  51.10443 1.000 32.26136 ? 124 GLY A O   1 
ATOM   950  N N   . VAL A 1 123 ? -8.36328  -4.30872  49.41885 1.000 28.78467 ? 125 VAL A N   1 
ATOM   951  C CA  . VAL A 1 123 ? -7.14462  -4.23168  48.62230 1.000 28.74573 ? 125 VAL A CA  1 
ATOM   952  C C   . VAL A 1 123 ? -7.04885  -2.82741  48.04579 1.000 34.80618 ? 125 VAL A C   1 
ATOM   953  O O   . VAL A 1 123 ? -8.05532  -2.26433  47.59569 1.000 30.29154 ? 125 VAL A O   1 
ATOM   954  C CB  . VAL A 1 123 ? -7.09466  -5.31447  47.51584 1.000 33.32958 ? 125 VAL A CB  1 
ATOM   955  C CG1 . VAL A 1 123 ? -8.27201  -5.20959  46.58505 1.000 35.15606 ? 125 VAL A CG1 1 
ATOM   956  C CG2 . VAL A 1 123 ? -5.78772  -5.21175  46.71507 1.000 32.67668 ? 125 VAL A CG2 1 
ATOM   957  N N   . TYR A 1 124 ? -5.85893  -2.23089  48.12669 1.000 28.70465 ? 126 TYR A N   1 
ATOM   958  C CA  . TYR A 1 124 ? -5.66038  -0.92213  47.53351 1.000 29.60948 ? 126 TYR A CA  1 
ATOM   959  C C   . TYR A 1 124 ? -4.21235  -0.77049  47.08992 1.000 30.00190 ? 126 TYR A C   1 
ATOM   960  O O   . TYR A 1 124 ? -3.33937  -1.55915  47.44868 1.000 26.67643 ? 126 TYR A O   1 
ATOM   961  C CB  . TYR A 1 124 ? -6.05457  0.18341   48.50181 1.000 30.90411 ? 126 TYR A CB  1 
ATOM   962  C CG  . TYR A 1 124 ? -5.32687  0.12852   49.82105 1.000 31.27620 ? 126 TYR A CG  1 
ATOM   963  C CD1 . TYR A 1 124 ? -4.10273  0.76269   49.97864 1.000 31.97906 ? 126 TYR A CD1 1 
ATOM   964  C CD2 . TYR A 1 124 ? -5.86031  -0.55293  50.90639 1.000 30.78290 ? 126 TYR A CD2 1 
ATOM   965  C CE1 . TYR A 1 124 ? -3.43121  0.73496   51.18860 1.000 35.48322 ? 126 TYR A CE1 1 
ATOM   966  C CE2 . TYR A 1 124 ? -5.19624  -0.59330  52.11812 1.000 35.48213 ? 126 TYR A CE2 1 
ATOM   967  C CZ  . TYR A 1 124 ? -3.98231  0.05823   52.25492 1.000 34.27124 ? 126 TYR A CZ  1 
ATOM   968  O OH  . TYR A 1 124 ? -3.31167  0.03512   53.45448 1.000 33.98069 ? 126 TYR A OH  1 
ATOM   969  N N   . GLN A 1 125 ? -3.96889  0.28584   46.32339 1.000 28.45944 ? 127 GLN A N   1 
ATOM   970  C CA  . GLN A 1 125 ? -2.66188  0.57804   45.75902 1.000 27.43947 ? 127 GLN A CA  1 
ATOM   971  C C   . GLN A 1 125 ? -1.97453  1.63751   46.61070 1.000 33.01865 ? 127 GLN A C   1 
ATOM   972  O O   . GLN A 1 125 ? -2.60142  2.63032   46.99060 1.000 30.22699 ? 127 GLN A O   1 
ATOM   973  C CB  . GLN A 1 125 ? -2.79732  1.07520   44.32299 1.000 32.29429 ? 127 GLN A CB  1 
ATOM   974  C CG  . GLN A 1 125 ? -1.48024  1.25006   43.60829 1.000 38.00569 ? 127 GLN A CG  1 
ATOM   975  C CD  . GLN A 1 125 ? -0.89977  -0.06712  43.14134 1.000 40.56663 ? 127 GLN A CD  1 
ATOM   976  O OE1 . GLN A 1 125 ? -1.43472  -1.14827  43.44466 1.000 41.46361 ? 127 GLN A OE1 1 
ATOM   977  N NE2 . GLN A 1 125 ? 0.19629   0.00892   42.38108 1.000 43.70433 ? 127 GLN A NE2 1 
ATOM   978  N N   . CYS A 1 126 ? -0.68751  1.42421   46.88733 1.000 31.19057 ? 128 CYS A N   1 
ATOM   979  C CA  . CYS A 1 126 ? 0.13790   2.22998   47.77974 1.000 36.47316 ? 128 CYS A CA  1 
ATOM   980  C C   . CYS A 1 126 ? 1.42078   2.64549   47.08103 1.000 36.87082 ? 128 CYS A C   1 
ATOM   981  O O   . CYS A 1 126 ? 1.85833   1.99404   46.13025 1.000 30.12116 ? 128 CYS A O   1 
ATOM   982  C CB  . CYS A 1 126 ? 0.53563   1.43629   49.03410 1.000 34.50634 ? 128 CYS A CB  1 
ATOM   983  S SG  . CYS A 1 126 ? -0.44563  1.79227   50.41026 1.000 60.72769 ? 128 CYS A SG  1 
ATOM   984  N N   . ALA A 1 127 ? 2.06209   3.70270   47.59809 1.000 35.02207 ? 129 ALA A N   1 
ATOM   985  C CA  . ALA A 1 127 ? 3.43789   4.00537   47.21830 1.000 31.51931 ? 129 ALA A CA  1 
ATOM   986  C C   . ALA A 1 127 ? 4.32156   4.10159   48.45623 1.000 36.66806 ? 129 ALA A C   1 
ATOM   987  O O   . ALA A 1 127 ? 3.88224   4.50899   49.53745 1.000 37.30603 ? 129 ALA A O   1 
ATOM   988  C CB  . ALA A 1 127 ? 3.56093   5.29920   46.39831 1.000 31.46224 ? 129 ALA A CB  1 
ATOM   989  N N   . MET A 1 128 ? 5.57456   3.69634   48.28185 1.000 31.73472 ? 130 MET A N   1 
ATOM   990  C CA  . MET A 1 128 ? 6.59804   3.86866   49.29867 1.000 29.26118 ? 130 MET A CA  1 
ATOM   991  C C   . MET A 1 128 ? 7.12482   5.29936   49.21046 1.000 32.66338 ? 130 MET A C   1 
ATOM   992  O O   . MET A 1 128 ? 7.67154   5.70484   48.17648 1.000 29.00244 ? 130 MET A O   1 
ATOM   993  C CB  . MET A 1 128 ? 7.70736   2.84787   49.07541 1.000 33.27948 ? 130 MET A CB  1 
ATOM   994  C CG  . MET A 1 128 ? 8.96462   3.06269   49.86415 1.000 38.00477 ? 130 MET A CG  1 
ATOM   995  S SD  . MET A 1 128 ? 8.85893   2.40275   51.52485 1.000 43.01372 ? 130 MET A SD  1 
ATOM   996  C CE  . MET A 1 128 ? 8.42419   0.66666   51.25288 1.000 33.21780 ? 130 MET A CE  1 
ATOM   997  N N   . ARG A 1 129 ? 6.93720   6.07362   50.27383 1.000 33.28692 ? 131 ARG A N   1 
ATOM   998  C CA  . ARG A 1 129 ? 7.30675   7.48246   50.22333 1.000 30.73712 ? 131 ARG A CA  1 
ATOM   999  C C   . ARG A 1 129 ? 8.82639   7.62407   50.16294 1.000 31.52060 ? 131 ARG A C   1 
ATOM   1000 O O   . ARG A 1 129 ? 9.55689   6.70378   50.53636 1.000 32.62895 ? 131 ARG A O   1 
ATOM   1001 C CB  . ARG A 1 129 ? 6.75112   8.22624   51.43541 1.000 30.81787 ? 131 ARG A CB  1 
ATOM   1002 C CG  . ARG A 1 129 ? 5.22488   8.19624   51.60258 1.000 31.62905 ? 131 ARG A CG  1 
ATOM   1003 C CD  . ARG A 1 129 ? 4.46263   8.73688   50.39495 1.000 30.45997 ? 131 ARG A CD  1 
ATOM   1004 N NE  . ARG A 1 129 ? 4.98691   10.02956  49.93252 1.000 33.51251 ? 131 ARG A NE  1 
ATOM   1005 C CZ  . ARG A 1 129 ? 4.62702   10.60918  48.79227 1.000 36.17627 ? 131 ARG A CZ  1 
ATOM   1006 N NH1 . ARG A 1 129 ? 3.71472   10.01743  48.02676 1.000 30.77564 ? 131 ARG A NH1 1 
ATOM   1007 N NH2 . ARG A 1 129 ? 5.15816   11.78483  48.42992 1.000 33.46770 ? 131 ARG A NH2 1 
ATOM   1008 N N   . PRO A 1 130 ? 9.32822   8.77231   49.68268 1.000 31.12546 ? 132 PRO A N   1 
ATOM   1009 C CA  . PRO A 1 130 ? 10.78197  9.02266   49.73552 1.000 32.41230 ? 132 PRO A CA  1 
ATOM   1010 C C   . PRO A 1 130 ? 11.39062  8.84393   51.11829 1.000 33.85794 ? 132 PRO A C   1 
ATOM   1011 O O   . PRO A 1 130 ? 12.56234  8.45771   51.22331 1.000 33.77680 ? 132 PRO A O   1 
ATOM   1012 C CB  . PRO A 1 130 ? 10.90058  10.48323  49.26019 1.000 33.97021 ? 132 PRO A CB  1 
ATOM   1013 C CG  . PRO A 1 130 ? 9.72102   10.66682  48.34885 1.000 34.15019 ? 132 PRO A CG  1 
ATOM   1014 C CD  . PRO A 1 130 ? 8.60807   9.82574   48.93649 1.000 31.51930 ? 132 PRO A CD  1 
ATOM   1015 N N   . ASN A 1 131 ? 10.64103  9.13161   52.18453 1.000 29.23696 ? 133 ASN A N   1 
ATOM   1016 C CA  . ASN A 1 131 ? 11.12729  8.94657   53.54341 1.000 34.50609 ? 133 ASN A CA  1 
ATOM   1017 C C   . ASN A 1 131 ? 10.81125  7.55532   54.10742 1.000 31.12067 ? 133 ASN A C   1 
ATOM   1018 O O   . ASN A 1 131 ? 10.85167  7.37164   55.32915 1.000 29.93652 ? 133 ASN A O   1 
ATOM   1019 C CB  . ASN A 1 131 ? 10.55551  10.03877  54.44951 1.000 32.02842 ? 133 ASN A CB  1 
ATOM   1020 C CG  . ASN A 1 131 ? 9.07711   9.88905   54.68006 1.000 32.34403 ? 133 ASN A CG  1 
ATOM   1021 O OD1 . ASN A 1 131 ? 8.43160   8.96210   54.16701 1.000 30.53873 ? 133 ASN A OD1 1 
ATOM   1022 N ND2 . ASN A 1 131 ? 8.52471   10.79556  55.46551 1.000 34.32660 ? 133 ASN A ND2 1 
ATOM   1023 N N   . PHE A 1 132 ? 10.46725  6.59170   53.24764 1.000 29.99229 ? 134 PHE A N   1 
ATOM   1024 C CA  . PHE A 1 132 ? 10.29183  5.17592   53.60421 1.000 30.66084 ? 134 PHE A CA  1 
ATOM   1025 C C   . PHE A 1 132 ? 9.11664   4.92754   54.53430 1.000 30.71977 ? 134 PHE A C   1 
ATOM   1026 O O   . PHE A 1 132 ? 9.05260   3.88262   55.19244 1.000 30.32585 ? 134 PHE A O   1 
ATOM   1027 C CB  . PHE A 1 132 ? 11.56089  4.57552   54.21909 1.000 25.80892 ? 134 PHE A CB  1 
ATOM   1028 C CG  . PHE A 1 132 ? 12.68063  4.43350   53.24680 1.000 28.52692 ? 134 PHE A CG  1 
ATOM   1029 C CD1 . PHE A 1 132 ? 12.64725  3.44894   52.28045 1.000 34.61403 ? 134 PHE A CD1 1 
ATOM   1030 C CD2 . PHE A 1 132 ? 13.75901  5.30778   53.27941 1.000 39.24470 ? 134 PHE A CD2 1 
ATOM   1031 C CE1 . PHE A 1 132 ? 13.68582  3.32085   51.36428 1.000 41.49115 ? 134 PHE A CE1 1 
ATOM   1032 C CE2 . PHE A 1 132 ? 14.79077  5.18892   52.37160 1.000 37.36395 ? 134 PHE A CE2 1 
ATOM   1033 C CZ  . PHE A 1 132 ? 14.75671  4.19200   51.41315 1.000 41.10649 ? 134 PHE A CZ  1 
ATOM   1034 N N   . THR A 1 133 ? 8.19590   5.86873   54.62496 1.000 29.04239 ? 135 THR A N   1 
ATOM   1035 C CA  . THR A 1 133 ? 6.89673   5.59673   55.21107 1.000 30.95241 ? 135 THR A CA  1 
ATOM   1036 C C   . THR A 1 133 ? 5.93186   5.18595   54.10480 1.000 32.15149 ? 135 THR A C   1 
ATOM   1037 O O   . THR A 1 133 ? 6.19882   5.36838   52.91456 1.000 32.97534 ? 135 THR A O   1 
ATOM   1038 C CB  . THR A 1 133 ? 6.37445   6.83362   55.93127 1.000 33.39788 ? 135 THR A CB  1 
ATOM   1039 O OG1 . THR A 1 133 ? 6.26041   7.90284   54.97730 1.000 30.16810 ? 135 THR A OG1 1 
ATOM   1040 C CG2 . THR A 1 133 ? 7.33804   7.24530   57.01472 1.000 33.19785 ? 135 THR A CG2 1 
ATOM   1041 N N   . ILE A 1 134 ? 4.78965   4.63607   54.49263 1.000 30.84690 ? 136 ILE A N   1 
ATOM   1042 C CA  . ILE A 1 134 ? 3.68975   4.48835   53.55321 1.000 33.97250 ? 136 ILE A CA  1 
ATOM   1043 C C   . ILE A 1 134 ? 2.47085   5.18042   54.14868 1.000 34.54335 ? 136 ILE A C   1 
ATOM   1044 O O   . ILE A 1 134 ? 2.26112   5.15385   55.36488 1.000 34.62894 ? 136 ILE A O   1 
ATOM   1045 C CB  . ILE A 1 134 ? 3.40308   3.01086   53.18027 1.000 35.74256 ? 136 ILE A CB  1 
ATOM   1046 C CG1 . ILE A 1 134 ? 2.60887   2.29230   54.25157 1.000 35.82973 ? 136 ILE A CG1 1 
ATOM   1047 C CG2 . ILE A 1 134 ? 4.69788   2.23622   52.88970 1.000 30.94418 ? 136 ILE A CG2 1 
ATOM   1048 C CD1 . ILE A 1 134 ? 2.19150   0.90763   53.82140 1.000 38.39596 ? 136 ILE A CD1 1 
ATOM   1049 N N   . LYS A 1 135 ? 1.69980   5.85256   53.29101 1.000 31.57114 ? 137 LYS A N   1 
ATOM   1050 C CA  . LYS A 1 135 ? 0.43309   6.46190   53.69434 1.000 35.89998 ? 137 LYS A CA  1 
ATOM   1051 C C   . LYS A 1 135 ? -0.65100  5.42730   53.42882 1.000 36.68091 ? 137 LYS A C   1 
ATOM   1052 O O   . LYS A 1 135 ? -1.34503  5.44052   52.40943 1.000 37.93453 ? 137 LYS A O   1 
ATOM   1053 C CB  . LYS A 1 135 ? 0.18081   7.76725   52.93715 1.000 34.62457 ? 137 LYS A CB  1 
ATOM   1054 C CG  . LYS A 1 135 ? 1.28714   8.80526   53.09294 1.000 38.50791 ? 137 LYS A CG  1 
ATOM   1055 C CD  . LYS A 1 135 ? 0.72691   10.18592  53.42388 1.000 48.22387 ? 137 LYS A CD  1 
ATOM   1056 C CE  . LYS A 1 135 ? 0.84354   11.16056  52.24961 1.000 52.01273 ? 137 LYS A CE  1 
ATOM   1057 N NZ  . LYS A 1 135 ? 2.14318   11.89693  52.19680 1.000 47.69853 ? 137 LYS A NZ  1 
ATOM   1058 N N   . GLY A 1 136 ? -0.77015  4.48518   54.35349 1.000 37.33590 ? 138 GLY A N   1 
ATOM   1059 C CA  . GLY A 1 136 ? -1.67548  3.37106   54.18234 1.000 39.35804 ? 138 GLY A CA  1 
ATOM   1060 C C   . GLY A 1 136 ? -3.01597  3.61448   54.84951 1.000 37.59303 ? 138 GLY A C   1 
ATOM   1061 O O   . GLY A 1 136 ? -3.23102  4.61258   55.52876 1.000 36.88830 ? 138 GLY A O   1 
ATOM   1062 N N   . SER A 1 137 ? -3.92657  2.67653   54.63020 1.000 34.59998 ? 139 SER A N   1 
ATOM   1063 C CA  . SER A 1 137 ? -5.18116  2.61027   55.37278 1.000 35.61698 ? 139 SER A CA  1 
ATOM   1064 C C   . SER A 1 137 ? -5.12124  1.30562   56.15893 1.000 37.18783 ? 139 SER A C   1 
ATOM   1065 O O   . SER A 1 137 ? -5.41933  0.22767   55.62747 1.000 35.92247 ? 139 SER A O   1 
ATOM   1066 C CB  . SER A 1 137 ? -6.39984  2.67691   54.45117 1.000 38.08305 ? 139 SER A CB  1 
ATOM   1067 O OG  . SER A 1 137 ? -6.64452  4.01683   54.03947 1.000 52.87190 ? 139 SER A OG  1 
ATOM   1068 N N   . PHE A 1 138 ? -4.71306  1.41922   57.41847 1.000 33.52352 ? 140 PHE A N   1 
ATOM   1069 C CA  . PHE A 1 138 ? -4.45868  0.29419   58.30750 1.000 29.93709 ? 140 PHE A CA  1 
ATOM   1070 C C   . PHE A 1 138 ? -5.03379  0.64566   59.67062 1.000 33.65616 ? 140 PHE A C   1 
ATOM   1071 O O   . PHE A 1 138 ? -4.72281  1.71753   60.21160 1.000 33.38911 ? 140 PHE A O   1 
ATOM   1072 C CB  . PHE A 1 138 ? -2.96547  0.04875   58.49567 1.000 28.22383 ? 140 PHE A CB  1 
ATOM   1073 C CG  . PHE A 1 138 ? -2.25459  -0.52387  57.32528 1.000 31.20067 ? 140 PHE A CG  1 
ATOM   1074 C CD1 . PHE A 1 138 ? -2.62867  -1.73742  56.77704 1.000 32.27160 ? 140 PHE A CD1 1 
ATOM   1075 C CD2 . PHE A 1 138 ? -1.11912  0.10103   56.84270 1.000 34.23176 ? 140 PHE A CD2 1 
ATOM   1076 C CE1 . PHE A 1 138 ? -1.91524  -2.29014  55.72907 1.000 33.98269 ? 140 PHE A CE1 1 
ATOM   1077 C CE2 . PHE A 1 138 ? -0.40366  -0.44332  55.79215 1.000 34.15527 ? 140 PHE A CE2 1 
ATOM   1078 C CZ  . PHE A 1 138 ? -0.79419  -1.63916  55.23726 1.000 31.41555 ? 140 PHE A CZ  1 
ATOM   1079 N N   . LEU A 1 139 ? -5.83570  -0.24786  60.23445 1.000 32.83614 ? 141 LEU A N   1 
ATOM   1080 C CA  . LEU A 1 139 ? -6.34555  -0.08742  61.58881 1.000 34.64875 ? 141 LEU A CA  1 
ATOM   1081 C C   . LEU A 1 139 ? -5.51592  -0.93922  62.55058 1.000 31.57000 ? 141 LEU A C   1 
ATOM   1082 O O   . LEU A 1 139 ? -4.56961  -1.61805  62.15405 1.000 32.44498 ? 141 LEU A O   1 
ATOM   1083 C CB  . LEU A 1 139 ? -7.83065  -0.45325  61.64063 1.000 34.23909 ? 141 LEU A CB  1 
ATOM   1084 C CG  . LEU A 1 139 ? -8.73530  0.35555   60.70253 1.000 35.37579 ? 141 LEU A CG  1 
ATOM   1085 C CD1 . LEU A 1 139 ? -10.12043 -0.27371  60.67266 1.000 40.56734 ? 141 LEU A CD1 1 
ATOM   1086 C CD2 . LEU A 1 139 ? -8.80123  1.83030   61.11819 1.000 35.09169 ? 141 LEU A CD2 1 
ATOM   1087 N N   . ASN A 1 140 ? -5.84501  -0.86817  63.84137 1.000 37.63140 ? 142 ASN A N   1 
ATOM   1088 C CA  . ASN A 1 140 ? -5.19455  -1.74339  64.81126 1.000 31.92232 ? 142 ASN A CA  1 
ATOM   1089 C C   . ASN A 1 140 ? -5.37741  -3.18997  64.39812 1.000 31.92626 ? 142 ASN A C   1 
ATOM   1090 O O   . ASN A 1 140 ? -6.41002  -3.56562  63.84296 1.000 33.26364 ? 142 ASN A O   1 
ATOM   1091 C CB  . ASN A 1 140 ? -5.76539  -1.55080  66.21832 1.000 37.73237 ? 142 ASN A CB  1 
ATOM   1092 C CG  . ASN A 1 140 ? -5.57875  -0.14538  66.74513 1.000 38.69116 ? 142 ASN A CG  1 
ATOM   1093 O OD1 . ASN A 1 140 ? -4.49032  0.42421   66.68629 1.000 40.53492 ? 142 ASN A OD1 1 
ATOM   1094 N ND2 . ASN A 1 140 ? -6.64121  0.40956   67.29748 1.000 47.27291 ? 142 ASN A ND2 1 
ATOM   1095 N N   . GLY A 1 141 ? -4.35797  -4.00804  64.66318 1.000 32.46108 ? 143 GLY A N   1 
ATOM   1096 C CA  . GLY A 1 141 ? -4.41451  -5.39761  64.27852 1.000 30.11185 ? 143 GLY A CA  1 
ATOM   1097 C C   . GLY A 1 141 ? -4.18951  -5.66425  62.80695 1.000 31.12766 ? 143 GLY A C   1 
ATOM   1098 O O   . GLY A 1 141 ? -4.32979  -6.81308  62.37480 1.000 28.75048 ? 143 GLY A O   1 
ATOM   1099 N N   . SER A 1 142 ? -3.85468  -4.64732  62.02045 1.000 30.22510 ? 144 SER A N   1 
ATOM   1100 C CA  . SER A 1 142 ? -3.55163  -4.88220  60.61466 1.000 31.45073 ? 144 SER A CA  1 
ATOM   1101 C C   . SER A 1 142 ? -2.13943  -5.39582  60.40890 1.000 28.66396 ? 144 SER A C   1 
ATOM   1102 O O   . SER A 1 142 ? -1.79690  -5.75616  59.27789 1.000 24.76453 ? 144 SER A O   1 
ATOM   1103 C CB  . SER A 1 142 ? -3.74478  -3.59640  59.80040 1.000 29.90257 ? 144 SER A CB  1 
ATOM   1104 O OG  . SER A 1 142 ? -2.88569  -2.57193  60.25827 1.000 33.36948 ? 144 SER A OG  1 
ATOM   1105 N N   . CYS A 1 143 ? -1.31951  -5.42183  61.46686 1.000 25.46517 ? 145 CYS A N   1 
ATOM   1106 C CA  . CYS A 1 143 ? 0.05802   -5.89234  61.35619 1.000 26.18663 ? 145 CYS A CA  1 
ATOM   1107 C C   . CYS A 1 143 ? 0.11516   -7.27336  60.72620 1.000 24.59777 ? 145 CYS A C   1 
ATOM   1108 O O   . CYS A 1 143 ? -0.71110  -8.13932  61.01333 1.000 24.89654 ? 145 CYS A O   1 
ATOM   1109 C CB  . CYS A 1 143 ? 0.71400   -5.94136  62.73902 1.000 26.36713 ? 145 CYS A CB  1 
ATOM   1110 S SG  . CYS A 1 143 ? 0.34280   -4.48865  63.73937 1.000 32.50644 ? 145 CYS A SG  1 
ATOM   1111 N N   . GLY A 1 144 ? 1.13960   -7.49050  59.90370 1.000 26.69690 ? 146 GLY A N   1 
ATOM   1112 C CA  . GLY A 1 144 ? 1.26735   -8.71312  59.15518 1.000 24.71128 ? 146 GLY A CA  1 
ATOM   1113 C C   . GLY A 1 144 ? 0.61709   -8.67441  57.79531 1.000 22.87407 ? 146 GLY A C   1 
ATOM   1114 O O   . GLY A 1 144 ? 0.83801   -9.59729  56.99495 1.000 26.09160 ? 146 GLY A O   1 
ATOM   1115 N N   . SER A 1 145 ? -0.19233  -7.65286  57.50875 1.000 27.02327 ? 147 SER A N   1 
ATOM   1116 C CA  . SER A 1 145 ? -0.68328  -7.46679  56.15013 1.000 26.16277 ? 147 SER A CA  1 
ATOM   1117 C C   . SER A 1 145 ? 0.49465   -7.20968  55.22719 1.000 26.97359 ? 147 SER A C   1 
ATOM   1118 O O   . SER A 1 145 ? 1.48924   -6.59887  55.62735 1.000 25.85930 ? 147 SER A O   1 
ATOM   1119 C CB  . SER A 1 145 ? -1.65097  -6.28716  56.07956 1.000 27.35291 ? 147 SER A CB  1 
ATOM   1120 O OG  . SER A 1 145 ? -2.85047  -6.56371  56.76465 1.000 31.29165 ? 147 SER A OG  1 
ATOM   1121 N N   . VAL A 1 146 ? 0.37076   -7.63779  53.96060 1.000 26.64510 ? 148 VAL A N   1 
ATOM   1122 C CA  . VAL A 1 146 ? 1.51357   -7.54734  53.05839 1.000 27.29911 ? 148 VAL A CA  1 
ATOM   1123 C C   . VAL A 1 146 ? 1.18477   -6.67908  51.85066 1.000 27.40115 ? 148 VAL A C   1 
ATOM   1124 O O   . VAL A 1 146 ? 0.02470   -6.51696  51.46113 1.000 27.00590 ? 148 VAL A O   1 
ATOM   1125 C CB  . VAL A 1 146 ? 2.02327   -8.93440  52.60445 1.000 27.30913 ? 148 VAL A CB  1 
ATOM   1126 C CG1 . VAL A 1 146 ? 2.60153   -9.69811  53.80844 1.000 27.61459 ? 148 VAL A CG1 1 
ATOM   1127 C CG2 . VAL A 1 146 ? 0.92103   -9.72180  51.90116 1.000 24.69420 ? 148 VAL A CG2 1 
ATOM   1128 N N   . GLY A 1 147 ? 2.23555   -6.07945  51.29468 1.000 24.23164 ? 149 GLY A N   1 
ATOM   1129 C CA  . GLY A 1 147 ? 2.17269   -5.38957  50.02070 1.000 25.12712 ? 149 GLY A CA  1 
ATOM   1130 C C   . GLY A 1 147 ? 2.89847   -6.21745  48.97508 1.000 27.46716 ? 149 GLY A C   1 
ATOM   1131 O O   . GLY A 1 147 ? 3.86001   -6.93377  49.28334 1.000 25.85665 ? 149 GLY A O   1 
ATOM   1132 N N   . PHE A 1 148 ? 2.42841   -6.13840  47.73548 1.000 26.16369 ? 150 PHE A N   1 
ATOM   1133 C CA  . PHE A 1 148 ? 2.91994   -7.06405  46.72778 1.000 28.13861 ? 150 PHE A CA  1 
ATOM   1134 C C   . PHE A 1 148 ? 2.73927   -6.46656  45.34305 1.000 27.05863 ? 150 PHE A C   1 
ATOM   1135 O O   . PHE A 1 148 ? 1.98279   -5.51482  45.14193 1.000 25.10220 ? 150 PHE A O   1 
ATOM   1136 C CB  . PHE A 1 148 ? 2.19186   -8.41015  46.81241 1.000 27.51411 ? 150 PHE A CB  1 
ATOM   1137 C CG  . PHE A 1 148 ? 0.70380   -8.31180  46.56561 1.000 27.77759 ? 150 PHE A CG  1 
ATOM   1138 C CD1 . PHE A 1 148 ? -0.16069  -7.92135  47.58160 1.000 25.55793 ? 150 PHE A CD1 1 
ATOM   1139 C CD2 . PHE A 1 148 ? 0.16899   -8.61177  45.30943 1.000 31.21140 ? 150 PHE A CD2 1 
ATOM   1140 C CE1 . PHE A 1 148 ? -1.54056  -7.82678  47.34870 1.000 29.22951 ? 150 PHE A CE1 1 
ATOM   1141 C CE2 . PHE A 1 148 ? -1.21257  -8.51525  45.05921 1.000 28.14827 ? 150 PHE A CE2 1 
ATOM   1142 C CZ  . PHE A 1 148 ? -2.06838  -8.12116  46.08236 1.000 28.31752 ? 150 PHE A CZ  1 
ATOM   1143 N N   . ASN A 1 149 ? 3.46512   -7.03796  44.39377 1.000 30.72598 ? 151 ASN A N   1 
ATOM   1144 C CA  . ASN A 1 149 ? 3.22268   -6.83557  42.97680 1.000 30.64913 ? 151 ASN A CA  1 
ATOM   1145 C C   . ASN A 1 149 ? 3.12132   -8.20280  42.31880 1.000 34.39819 ? 151 ASN A C   1 
ATOM   1146 O O   . ASN A 1 149 ? 3.59416   -9.20943  42.84936 1.000 35.20925 ? 151 ASN A O   1 
ATOM   1147 C CB  . ASN A 1 149 ? 4.33604   -6.02255  42.32042 1.000 31.21368 ? 151 ASN A CB  1 
ATOM   1148 C CG  . ASN A 1 149 ? 4.27944   -4.56887  42.68605 1.000 35.19006 ? 151 ASN A CG  1 
ATOM   1149 O OD1 . ASN A 1 149 ? 3.40695   -3.83995  42.21063 1.000 35.21412 ? 151 ASN A OD1 1 
ATOM   1150 N ND2 . ASN A 1 149 ? 5.19910   -4.12983  43.55184 1.000 30.44660 ? 151 ASN A ND2 1 
ATOM   1151 N N   . ILE A 1 150 ? 2.48259   -8.24346  41.16066 1.000 36.45998 ? 152 ILE A N   1 
ATOM   1152 C CA  . ILE A 1 150 ? 2.37831   -9.47059  40.39112 1.000 35.34816 ? 152 ILE A CA  1 
ATOM   1153 C C   . ILE A 1 150 ? 3.10086   -9.25677  39.07373 1.000 43.39233 ? 152 ILE A C   1 
ATOM   1154 O O   . ILE A 1 150 ? 2.87633   -8.24806  38.39120 1.000 38.04809 ? 152 ILE A O   1 
ATOM   1155 C CB  . ILE A 1 150 ? 0.91549   -9.88289  40.19186 1.000 30.78970 ? 152 ILE A CB  1 
ATOM   1156 C CG1 . ILE A 1 150 ? 0.29202   -10.07843 41.56507 1.000 35.93331 ? 152 ILE A CG1 1 
ATOM   1157 C CG2 . ILE A 1 150 ? 0.83229   -11.20621 39.41755 1.000 44.79904 ? 152 ILE A CG2 1 
ATOM   1158 C CD1 . ILE A 1 150 ? -1.10868  -10.58500 41.54474 1.000 41.54550 ? 152 ILE A CD1 1 
ATOM   1159 N N   . ASP A 1 151 ? 4.01982   -10.16772 38.75677 1.000 45.88911 ? 153 ASP A N   1 
ATOM   1160 C CA  . ASP A 1 151 ? 4.70679   -10.18149 37.46907 1.000 49.53516 ? 153 ASP A CA  1 
ATOM   1161 C C   . ASP A 1 151 ? 4.50530   -11.55122 36.84890 1.000 51.03209 ? 153 ASP A C   1 
ATOM   1162 O O   . ASP A 1 151 ? 4.99991   -12.55528 37.37593 1.000 53.51522 ? 153 ASP A O   1 
ATOM   1163 C CB  . ASP A 1 151 ? 6.19591   -9.86619  37.60211 1.000 53.53309 ? 153 ASP A CB  1 
ATOM   1164 C CG  . ASP A 1 151 ? 6.88022   -9.72007  36.23866 1.000 67.38565 ? 153 ASP A CG  1 
ATOM   1165 O OD1 . ASP A 1 151 ? 6.16553   -9.73778  35.19872 1.000 64.80629 ? 153 ASP A OD1 1 
ATOM   1166 O OD2 . ASP A 1 151 ? 8.12435   -9.58968  36.20422 1.000 69.24838 ? 153 ASP A OD2 1 
ATOM   1167 N N   . TYR A 1 152 ? 3.78533   -11.58844 35.73153 1.000 56.81734 ? 154 TYR A N   1 
ATOM   1168 C CA  . TYR A 1 152 ? 3.46540   -12.83884 35.05291 1.000 54.34611 ? 154 TYR A CA  1 
ATOM   1169 C C   . TYR A 1 152 ? 2.67854   -13.68632 36.04536 1.000 55.87616 ? 154 TYR A C   1 
ATOM   1170 O O   . TYR A 1 152 ? 1.57413   -13.26719 36.44322 1.000 56.66339 ? 154 TYR A O   1 
ATOM   1171 C CB  . TYR A 1 152 ? 4.77577   -13.42872 34.51552 1.000 58.30147 ? 154 TYR A CB  1 
ATOM   1172 C CG  . TYR A 1 152 ? 4.59923   -14.56993 33.55198 1.000 58.29171 ? 154 TYR A CG  1 
ATOM   1173 C CD1 . TYR A 1 152 ? 3.54553   -14.59407 32.64576 1.000 56.79435 ? 154 TYR A CD1 1 
ATOM   1174 C CD2 . TYR A 1 152 ? 5.49098   -15.63981 33.55842 1.000 59.44258 ? 154 TYR A CD2 1 
ATOM   1175 C CE1 . TYR A 1 152 ? 3.39194   -15.66057 31.76716 1.000 56.39816 ? 154 TYR A CE1 1 
ATOM   1176 C CE2 . TYR A 1 152 ? 5.34696   -16.70255 32.68764 1.000 55.73384 ? 154 TYR A CE2 1 
ATOM   1177 C CZ  . TYR A 1 152 ? 4.29763   -16.70888 31.79539 1.000 55.61424 ? 154 TYR A CZ  1 
ATOM   1178 O OH  . TYR A 1 152 ? 4.15643   -17.76959 30.92803 1.000 65.31105 ? 154 TYR A OH  1 
ATOM   1179 N N   . ASP A 1 153 ? 3.18410   -14.83251 36.49360 1.000 52.60831 ? 155 ASP A N   1 
ATOM   1180 C CA  . ASP A 1 153 ? 2.45785   -15.70851 37.40330 1.000 50.16062 ? 155 ASP A CA  1 
ATOM   1181 C C   . ASP A 1 153 ? 3.05575   -15.71599 38.80152 1.000 48.20073 ? 155 ASP A C   1 
ATOM   1182 O O   . ASP A 1 153 ? 2.73655   -16.60450 39.60088 1.000 50.27755 ? 155 ASP A O   1 
ATOM   1183 C CB  . ASP A 1 153 ? 2.43812   -17.13008 36.84436 1.000 54.27137 ? 155 ASP A CB  1 
ATOM   1184 C CG  . ASP A 1 153 ? 3.82366   -17.60693 36.41841 1.000 55.31806 ? 155 ASP A CG  1 
ATOM   1185 O OD1 . ASP A 1 153 ? 4.77384   -16.80211 36.47846 1.000 53.90021 ? 155 ASP A OD1 1 
ATOM   1186 O OD2 . ASP A 1 153 ? 3.96310   -18.78613 36.02986 1.000 65.21302 ? 155 ASP A OD2 1 
ATOM   1187 N N   . CYS A 1 154 ? 3.93025   -14.76175 39.10459 1.000 41.47956 ? 156 CYS A N   1 
ATOM   1188 C CA  . CYS A 1 154 ? 4.71841   -14.75864 40.32670 1.000 45.94949 ? 156 CYS A CA  1 
ATOM   1189 C C   . CYS A 1 154 ? 4.33915   -13.56601 41.20144 1.000 43.01889 ? 156 CYS A C   1 
ATOM   1190 O O   . CYS A 1 154 ? 4.31168   -12.42164 40.72828 1.000 40.42774 ? 156 CYS A O   1 
ATOM   1191 C CB  . CYS A 1 154 ? 6.20871   -14.71782 39.98586 1.000 43.01151 ? 156 CYS A CB  1 
ATOM   1192 S SG  . CYS A 1 154 ? 7.26584   -14.58195 41.42853 1.000 50.69700 ? 156 CYS A SG  1 
ATOM   1193 N N   . VAL A 1 155 ? 4.05799   -13.83105 42.47500 1.000 38.16050 ? 157 VAL A N   1 
ATOM   1194 C CA  . VAL A 1 155 ? 3.80817   -12.77351 43.45060 1.000 33.01267 ? 157 VAL A CA  1 
ATOM   1195 C C   . VAL A 1 155 ? 5.14095   -12.30337 44.02595 1.000 35.38183 ? 157 VAL A C   1 
ATOM   1196 O O   . VAL A 1 155 ? 5.86843   -13.08456 44.64767 1.000 34.87390 ? 157 VAL A O   1 
ATOM   1197 C CB  . VAL A 1 155 ? 2.87608   -13.25551 44.57159 1.000 36.60793 ? 157 VAL A CB  1 
ATOM   1198 C CG1 . VAL A 1 155 ? 2.62383   -12.10784 45.58243 1.000 30.91846 ? 157 VAL A CG1 1 
ATOM   1199 C CG2 . VAL A 1 155 ? 1.57342   -13.79705 43.99346 1.000 35.44342 ? 157 VAL A CG2 1 
ATOM   1200 N N   . SER A 1 156 ? 5.44659   -11.01908 43.85051 1.000 34.08245 ? 158 SER A N   1 
ATOM   1201 C CA  . SER A 1 156 ? 6.61276   -10.38481 44.45753 1.000 34.30238 ? 158 SER A CA  1 
ATOM   1202 C C   . SER A 1 156 ? 6.16102   -9.68628  45.73705 1.000 34.68867 ? 158 SER A C   1 
ATOM   1203 O O   . SER A 1 156 ? 5.58373   -8.59556  45.69187 1.000 30.69442 ? 158 SER A O   1 
ATOM   1204 C CB  . SER A 1 156 ? 7.26160   -9.39245  43.49528 1.000 35.62243 ? 158 SER A CB  1 
ATOM   1205 O OG  . SER A 1 156 ? 7.96249   -10.07407 42.46901 1.000 43.83644 ? 158 SER A OG  1 
ATOM   1206 N N   . PHE A 1 157 ? 6.42247   -10.31659 46.88040 1.000 33.08705 ? 159 PHE A N   1 
ATOM   1207 C CA  . PHE A 1 157 ? 6.16369   -9.68789  48.16891 1.000 28.05581 ? 159 PHE A CA  1 
ATOM   1208 C C   . PHE A 1 157 ? 7.24409   -8.66373  48.47799 1.000 29.15478 ? 159 PHE A C   1 
ATOM   1209 O O   . PHE A 1 157 ? 8.43184   -8.99831  48.48359 1.000 30.00132 ? 159 PHE A O   1 
ATOM   1210 C CB  . PHE A 1 157 ? 6.11794   -10.74379 49.26662 1.000 27.36006 ? 159 PHE A CB  1 
ATOM   1211 C CG  . PHE A 1 157 ? 4.99457   -11.69678 49.11922 1.000 27.12541 ? 159 PHE A CG  1 
ATOM   1212 C CD1 . PHE A 1 157 ? 3.71417   -11.31855 49.45330 1.000 23.63287 ? 159 PHE A CD1 1 
ATOM   1213 C CD2 . PHE A 1 157 ? 5.21141   -12.98175 48.64711 1.000 29.38747 ? 159 PHE A CD2 1 
ATOM   1214 C CE1 . PHE A 1 157 ? 2.65730   -12.18846 49.32231 1.000 26.69883 ? 159 PHE A CE1 1 
ATOM   1215 C CE2 . PHE A 1 157 ? 4.15981   -13.86128 48.51443 1.000 28.97612 ? 159 PHE A CE2 1 
ATOM   1216 C CZ  . PHE A 1 157 ? 2.88320   -13.47450 48.85329 1.000 27.93603 ? 159 PHE A CZ  1 
ATOM   1217 N N   . CYS A 1 158 ? 6.83264   -7.41435  48.75554 1.000 27.75641 ? 160 CYS A N   1 
ATOM   1218 C CA  . CYS A 1 158 ? 7.78080   -6.35262  49.07038 1.000 29.43391 ? 160 CYS A CA  1 
ATOM   1219 C C   . CYS A 1 158 ? 7.58907   -5.68104  50.42554 1.000 28.64911 ? 160 CYS A C   1 
ATOM   1220 O O   . CYS A 1 158 ? 8.46576   -4.90634  50.83604 1.000 30.86524 ? 160 CYS A O   1 
ATOM   1221 C CB  . CYS A 1 158 ? 7.73593   -5.25107  47.99945 1.000 29.39540 ? 160 CYS A CB  1 
ATOM   1222 S SG  . CYS A 1 158 ? 6.08970   -4.53599  47.71918 1.000 30.21526 ? 160 CYS A SG  1 
ATOM   1223 N N   . TYR A 1 159 ? 6.47587   -5.90095  51.11347 1.000 25.63816 ? 161 TYR A N   1 
ATOM   1224 C CA  . TYR A 1 159 ? 6.20731   -5.11600  52.31405 1.000 29.11175 ? 161 TYR A CA  1 
ATOM   1225 C C   . TYR A 1 159 ? 5.37845   -5.95726  53.27137 1.000 26.01495 ? 161 TYR A C   1 
ATOM   1226 O O   . TYR A 1 159 ? 4.45048   -6.65333  52.85235 1.000 26.47395 ? 161 TYR A O   1 
ATOM   1227 C CB  . TYR A 1 159 ? 5.48226   -3.80205  51.96332 1.000 28.57642 ? 161 TYR A CB  1 
ATOM   1228 C CG  . TYR A 1 159 ? 5.05460   -2.96229  53.15302 1.000 24.62438 ? 161 TYR A CG  1 
ATOM   1229 C CD1 . TYR A 1 159 ? 5.95548   -2.09583  53.77720 1.000 26.51346 ? 161 TYR A CD1 1 
ATOM   1230 C CD2 . TYR A 1 159 ? 3.74999   -3.02572  53.64599 1.000 25.00242 ? 161 TYR A CD2 1 
ATOM   1231 C CE1 . TYR A 1 159 ? 5.57900   -1.33137  54.86436 1.000 25.46974 ? 161 TYR A CE1 1 
ATOM   1232 C CE2 . TYR A 1 159 ? 3.36559   -2.26974  54.75230 1.000 22.60742 ? 161 TYR A CE2 1 
ATOM   1233 C CZ  . TYR A 1 159 ? 4.28959   -1.41864  55.34834 1.000 23.04512 ? 161 TYR A CZ  1 
ATOM   1234 O OH  . TYR A 1 159 ? 3.94531   -0.64278  56.43823 1.000 24.72690 ? 161 TYR A OH  1 
ATOM   1235 N N   . MET A 1 160 ? 5.75251   -5.93616  54.54409 1.000 28.54280 ? 162 MET A N   1 
ATOM   1236 C CA  . MET A 1 160 ? 4.90745   -6.46406  55.60471 1.000 25.99965 ? 162 MET A CA  1 
ATOM   1237 C C   . MET A 1 160 ? 4.63505   -5.32198  56.57588 1.000 23.70096 ? 162 MET A C   1 
ATOM   1238 O O   . MET A 1 160 ? 5.56817   -4.65186  57.02767 1.000 24.92987 ? 162 MET A O   1 
ATOM   1239 C CB  . MET A 1 160 ? 5.56222   -7.65483  56.31697 1.000 25.38051 ? 162 MET A CB  1 
ATOM   1240 C CG  . MET A 1 160 ? 4.82831   -8.03076  57.60372 1.000 25.37485 ? 162 MET A CG  1 
ATOM   1241 S SD  . MET A 1 160 ? 5.22070   -9.68588  58.23909 1.000 32.52030 ? 162 MET A SD  1 
ATOM   1242 C CE  . MET A 1 160 ? 4.33229   -10.72413 57.07560 1.000 30.12972 ? 162 MET A CE  1 
ATOM   1243 N N   . HIS A 1 161 ? 3.36959   -5.08028  56.88008 1.000 23.20264 ? 163 HIS A N   1 
ATOM   1244 C CA  . HIS A 1 161 ? 3.04164   -3.95099  57.74522 1.000 25.39513 ? 163 HIS A CA  1 
ATOM   1245 C C   . HIS A 1 161 ? 3.37837   -4.24812  59.20926 1.000 24.01305 ? 163 HIS A C   1 
ATOM   1246 O O   . HIS A 1 161 ? 3.04636   -5.31681  59.72511 1.000 24.84218 ? 163 HIS A O   1 
ATOM   1247 C CB  . HIS A 1 161 ? 1.56585   -3.61102  57.62568 1.000 25.59205 ? 163 HIS A CB  1 
ATOM   1248 C CG  . HIS A 1 161 ? 1.15153   -2.52551  58.55191 1.000 25.25745 ? 163 HIS A CG  1 
ATOM   1249 N ND1 . HIS A 1 161 ? 1.78537   -1.30279  58.57374 1.000 27.65550 ? 163 HIS A ND1 1 
ATOM   1250 C CD2 . HIS A 1 161 ? 0.20510   -2.48265  59.51866 1.000 27.20403 ? 163 HIS A CD2 1 
ATOM   1251 C CE1 . HIS A 1 161 ? 1.23040   -0.53988  59.50068 1.000 28.19445 ? 163 HIS A CE1 1 
ATOM   1252 N NE2 . HIS A 1 161 ? 0.26030   -1.22697  60.07799 1.000 26.45528 ? 163 HIS A NE2 1 
ATOM   1253 N N   . HIS A 1 162 ? 4.00470   -3.27704  59.89131 1.000 21.98463 ? 164 HIS A N   1 
ATOM   1254 C CA  . HIS A 1 162 ? 4.40923   -3.45001  61.28671 1.000 26.94982 ? 164 HIS A CA  1 
ATOM   1255 C C   . HIS A 1 162 ? 3.73324   -2.47827  62.23844 1.000 27.57548 ? 164 HIS A C   1 
ATOM   1256 O O   . HIS A 1 162 ? 3.20824   -2.91145  63.27142 1.000 29.00742 ? 164 HIS A O   1 
ATOM   1257 C CB  . HIS A 1 162 ? 5.93653   -3.32536  61.44565 1.000 24.25970 ? 164 HIS A CB  1 
ATOM   1258 C CG  . HIS A 1 162 ? 6.66990   -4.57648  61.09349 1.000 27.22894 ? 164 HIS A CG  1 
ATOM   1259 N ND1 . HIS A 1 162 ? 7.35120   -5.33298  62.02483 1.000 26.19403 ? 164 HIS A ND1 1 
ATOM   1260 C CD2 . HIS A 1 162 ? 6.80095   -5.22341  59.91005 1.000 24.58472 ? 164 HIS A CD2 1 
ATOM   1261 C CE1 . HIS A 1 162 ? 7.89693   -6.37477  61.42438 1.000 27.85379 ? 164 HIS A CE1 1 
ATOM   1262 N NE2 . HIS A 1 162 ? 7.57222   -6.33554  60.14242 1.000 29.31117 ? 164 HIS A NE2 1 
ATOM   1263 N N   . MET A 1 163 ? 3.71997   -1.18268  61.93004 1.000 27.40381 ? 165 MET A N   1 
ATOM   1264 C CA  . MET A 1 163 ? 3.29678   -0.20822  62.93056 1.000 31.18211 ? 165 MET A CA  1 
ATOM   1265 C C   . MET A 1 163 ? 2.89002   1.10859   62.29713 1.000 30.73109 ? 165 MET A C   1 
ATOM   1266 O O   . MET A 1 163 ? 3.28551   1.44742   61.17964 1.000 28.45690 ? 165 MET A O   1 
ATOM   1267 C CB  . MET A 1 163 ? 4.40935   0.07728   63.93749 1.000 32.71095 ? 165 MET A CB  1 
ATOM   1268 C CG  . MET A 1 163 ? 5.63088   0.69932   63.28732 1.000 31.74623 ? 165 MET A CG  1 
ATOM   1269 S SD  . MET A 1 163 ? 7.03309   0.68321   64.40113 1.000 42.77264 ? 165 MET A SD  1 
ATOM   1270 C CE  . MET A 1 163 ? 6.61679   -0.81363  65.23935 1.000 44.11565 ? 165 MET A CE  1 
ATOM   1271 N N   . GLU A 1 164 ? 2.12254   1.86033   63.06855 1.000 32.63256 ? 166 GLU A N   1 
ATOM   1272 C CA  . GLU A 1 164 ? 1.75397   3.22360   62.75214 1.000 32.60801 ? 166 GLU A CA  1 
ATOM   1273 C C   . GLU A 1 164 ? 2.66837   4.18127   63.50059 1.000 35.33525 ? 166 GLU A C   1 
ATOM   1274 O O   . GLU A 1 164 ? 3.02507   3.94091   64.65773 1.000 36.00506 ? 166 GLU A O   1 
ATOM   1275 C CB  . GLU A 1 164 ? 0.30113   3.46590   63.14417 1.000 35.90659 ? 166 GLU A CB  1 
ATOM   1276 C CG  . GLU A 1 164 ? -0.30236  4.81175   62.73386 1.000 36.63872 ? 166 GLU A CG  1 
ATOM   1277 C CD  . GLU A 1 164 ? -1.72689  4.94626   63.26750 1.000 45.93263 ? 166 GLU A CD  1 
ATOM   1278 O OE1 . GLU A 1 164 ? -1.92494  4.81153   64.50032 1.000 45.44010 ? 166 GLU A OE1 1 
ATOM   1279 O OE2 . GLU A 1 164 ? -2.65547  5.12785   62.45205 1.000 51.94960 ? 166 GLU A OE2 1 
ATOM   1280 N N   . LEU A 1 165 ? 3.05549   5.22745   62.84361 1.000 36.96506 ? 167 LEU A N   1 
ATOM   1281 C CA  . LEU A 1 165 ? 3.73952   6.24141   63.62660 1.000 44.59349 ? 167 LEU A CA  1 
ATOM   1282 C C   . LEU A 1 165 ? 2.71377   7.22096   64.19895 1.000 49.19859 ? 167 LEU A C   1 
ATOM   1283 O O   . LEU A 1 165 ? 1.62086   7.36814   63.64354 1.000 46.66814 ? 167 LEU A O   1 
ATOM   1284 C CB  . LEU A 1 165 ? 4.75447   6.98717   62.75584 1.000 41.13206 ? 167 LEU A CB  1 
ATOM   1285 C CG  . LEU A 1 165 ? 5.82966   6.09683   62.12403 1.000 40.44005 ? 167 LEU A CG  1 
ATOM   1286 C CD1 . LEU A 1 165 ? 6.70088   6.90107   61.15667 1.000 43.04028 ? 167 LEU A CD1 1 
ATOM   1287 C CD2 . LEU A 1 165 ? 6.69165   5.43663   63.20066 1.000 41.24930 ? 167 LEU A CD2 1 
ATOM   1288 N N   . PRO A 1 166 ? 3.01722   7.90221   65.31282 1.000 52.90999 ? 168 PRO A N   1 
ATOM   1289 C CA  . PRO A 1 166 ? 2.03811   8.85276   65.88574 1.000 50.31770 ? 168 PRO A CA  1 
ATOM   1290 C C   . PRO A 1 166 ? 1.55954   9.91764   64.91021 1.000 50.91261 ? 168 PRO A C   1 
ATOM   1291 O O   . PRO A 1 166 ? 0.46633   10.46752  65.10119 1.000 50.99739 ? 168 PRO A O   1 
ATOM   1292 C CB  . PRO A 1 166 ? 2.79672   9.47714   67.06723 1.000 47.99888 ? 168 PRO A CB  1 
ATOM   1293 C CG  . PRO A 1 166 ? 3.81095   8.43641   67.44690 1.000 55.32289 ? 168 PRO A CG  1 
ATOM   1294 C CD  . PRO A 1 166 ? 4.23119   7.79448   66.14211 1.000 52.81395 ? 168 PRO A CD  1 
ATOM   1295 N N   . THR A 1 167 ? 2.33290   10.22115  63.87139 1.000 49.18412 ? 169 THR A N   1 
ATOM   1296 C CA  . THR A 1 167 ? 1.88122   11.10717  62.80586 1.000 47.03579 ? 169 THR A CA  1 
ATOM   1297 C C   . THR A 1 167 ? 0.86044   10.45900  61.88319 1.000 48.49866 ? 169 THR A C   1 
ATOM   1298 O O   . THR A 1 167 ? 0.36919   11.12681  60.96680 1.000 53.09383 ? 169 THR A O   1 
ATOM   1299 C CB  . THR A 1 167 ? 3.07664   11.55762  61.98735 1.000 51.14203 ? 169 THR A CB  1 
ATOM   1300 O OG1 . THR A 1 167 ? 3.37647   10.53341  61.03348 1.000 45.72296 ? 169 THR A OG1 1 
ATOM   1301 C CG2 . THR A 1 167 ? 4.28204   11.76596  62.90394 1.000 52.00866 ? 169 THR A CG2 1 
ATOM   1302 N N   . GLY A 1 168 ? 0.55518   9.17565   62.07411 1.000 49.71335 ? 170 GLY A N   1 
ATOM   1303 C CA  . GLY A 1 168 ? -0.44493  8.49403   61.28548 1.000 42.44215 ? 170 GLY A CA  1 
ATOM   1304 C C   . GLY A 1 168 ? 0.03999   7.84330   60.00878 1.000 40.89215 ? 170 GLY A C   1 
ATOM   1305 O O   . GLY A 1 168 ? -0.77466  7.23403   59.30347 1.000 44.32125 ? 170 GLY A O   1 
ATOM   1306 N N   . VAL A 1 169 ? 1.32072   7.95705   59.66148 1.000 37.76186 ? 171 VAL A N   1 
ATOM   1307 C CA  . VAL A 1 169 ? 1.80776   7.15761   58.54152 1.000 33.69134 ? 171 VAL A CA  1 
ATOM   1308 C C   . VAL A 1 169 ? 2.30280   5.82264   59.08782 1.000 33.51823 ? 171 VAL A C   1 
ATOM   1309 O O   . VAL A 1 169 ? 2.33813   5.61124   60.30522 1.000 33.56559 ? 171 VAL A O   1 
ATOM   1310 C CB  . VAL A 1 169 ? 2.91199   7.86135   57.74392 1.000 35.49586 ? 171 VAL A CB  1 
ATOM   1311 C CG1 . VAL A 1 169 ? 2.32751   9.04347   56.94371 1.000 40.12542 ? 171 VAL A CG1 1 
ATOM   1312 C CG2 . VAL A 1 169 ? 4.02992   8.29170   58.67684 1.000 33.56020 ? 171 VAL A CG2 1 
ATOM   1313 N N   . HIS A 1 170 ? 2.71344   4.92823   58.19617 1.000 28.31996 ? 172 HIS A N   1 
ATOM   1314 C CA  . HIS A 1 170 ? 2.93322   3.53496   58.55904 1.000 32.16634 ? 172 HIS A CA  1 
ATOM   1315 C C   . HIS A 1 170 ? 4.33642   3.09245   58.17000 1.000 27.56031 ? 172 HIS A C   1 
ATOM   1316 O O   . HIS A 1 170 ? 4.93941   3.60711   57.22146 1.000 29.11805 ? 172 HIS A O   1 
ATOM   1317 C CB  . HIS A 1 170 ? 1.86065   2.65059   57.91122 1.000 26.44159 ? 172 HIS A CB  1 
ATOM   1318 C CG  . HIS A 1 170 ? 0.46942   3.04442   58.29223 1.000 26.32710 ? 172 HIS A CG  1 
ATOM   1319 N ND1 . HIS A 1 170 ? -0.36744  3.73831   57.44473 1.000 32.50966 ? 172 HIS A ND1 1 
ATOM   1320 C CD2 . HIS A 1 170 ? -0.21512  2.89052   59.45191 1.000 28.78854 ? 172 HIS A CD2 1 
ATOM   1321 C CE1 . HIS A 1 170 ? -1.51703  3.97452   58.05663 1.000 31.65333 ? 172 HIS A CE1 1 
ATOM   1322 N NE2 . HIS A 1 170 ? -1.45327  3.46334   59.27342 1.000 27.10663 ? 172 HIS A NE2 1 
ATOM   1323 N N   . ALA A 1 171 ? 4.86289   2.14364   58.93538 1.000 27.24113 ? 173 ALA A N   1 
ATOM   1324 C CA  . ALA A 1 171 ? 6.21168   1.64635   58.73047 1.000 25.97265 ? 173 ALA A CA  1 
ATOM   1325 C C   . ALA A 1 171 ? 6.18241   0.12968   58.75741 1.000 23.26979 ? 173 ALA A C   1 
ATOM   1326 O O   . ALA A 1 171 ? 5.36635   -0.47855  59.45430 1.000 25.19422 ? 173 ALA A O   1 
ATOM   1327 C CB  . ALA A 1 171 ? 7.17725   2.18698   59.80355 1.000 24.42316 ? 173 ALA A CB  1 
ATOM   1328 N N   . GLY A 1 172 ? 7.06702   -0.47197  57.97798 1.000 24.48379 ? 174 GLY A N   1 
ATOM   1329 C CA  . GLY A 1 172 ? 7.14936   -1.91220  57.94112 1.000 23.99227 ? 174 GLY A CA  1 
ATOM   1330 C C   . GLY A 1 172 ? 8.43839   -2.33667  57.28427 1.000 26.41115 ? 174 GLY A C   1 
ATOM   1331 O O   . GLY A 1 172 ? 9.34008   -1.52300  57.06992 1.000 23.72684 ? 174 GLY A O   1 
ATOM   1332 N N   . THR A 1 173 ? 8.50360   -3.62949  56.95713 1.000 23.70135 ? 175 THR A N   1 
ATOM   1333 C CA  . THR A 1 173 ? 9.73111   -4.29726  56.55659 1.000 23.31142 ? 175 THR A CA  1 
ATOM   1334 C C   . THR A 1 173 ? 9.55741   -4.96817  55.19884 1.000 27.23236 ? 175 THR A C   1 
ATOM   1335 O O   . THR A 1 173 ? 8.44378   -5.15118  54.69036 1.000 25.62325 ? 175 THR A O   1 
ATOM   1336 C CB  . THR A 1 173 ? 10.15520  -5.37534  57.58537 1.000 25.96034 ? 175 THR A CB  1 
ATOM   1337 O OG1 . THR A 1 173 ? 9.18183   -6.43585  57.59643 1.000 26.56263 ? 175 THR A OG1 1 
ATOM   1338 C CG2 . THR A 1 173 ? 10.31131  -4.79929  58.99158 1.000 22.99796 ? 175 THR A CG2 1 
ATOM   1339 N N   . ASP A 1 174 ? 10.68593  -5.37713  54.62990 1.000 26.11965 ? 176 ASP A N   1 
ATOM   1340 C CA  . ASP A 1 174 ? 10.63756  -6.37928  53.58655 1.000 25.52100 ? 176 ASP A CA  1 
ATOM   1341 C C   . ASP A 1 174 ? 10.37814  -7.74096  54.23436 1.000 28.70248 ? 176 ASP A C   1 
ATOM   1342 O O   . ASP A 1 174 ? 10.27600  -7.86943  55.45801 1.000 26.11175 ? 176 ASP A O   1 
ATOM   1343 C CB  . ASP A 1 174 ? 11.92135  -6.34153  52.74180 1.000 31.74689 ? 176 ASP A CB  1 
ATOM   1344 C CG  . ASP A 1 174 ? 13.18565  -6.69633  53.52813 1.000 33.78688 ? 176 ASP A CG  1 
ATOM   1345 O OD1 . ASP A 1 174 ? 13.12420  -7.51717  54.48356 1.000 35.54276 ? 176 ASP A OD1 1 
ATOM   1346 O OD2 . ASP A 1 174 ? 14.26371  -6.16226  53.16942 1.000 35.77442 ? 176 ASP A OD2 1 
ATOM   1347 N N   . LEU A 1 175 ? 10.24154  -8.77473  53.41311 1.000 27.77728 ? 177 LEU A N   1 
ATOM   1348 C CA  . LEU A 1 175 ? 9.83849   -10.05704 53.96245 1.000 29.37438 ? 177 LEU A CA  1 
ATOM   1349 C C   . LEU A 1 175 ? 11.01359  -10.82337 54.56222 1.000 33.91791 ? 177 LEU A C   1 
ATOM   1350 O O   . LEU A 1 175 ? 10.81922  -11.93080 55.07138 1.000 32.78011 ? 177 LEU A O   1 
ATOM   1351 C CB  . LEU A 1 175 ? 9.11873   -10.88728 52.88621 1.000 29.61600 ? 177 LEU A CB  1 
ATOM   1352 C CG  . LEU A 1 175 ? 7.59678   -10.65703 52.79981 1.000 29.57330 ? 177 LEU A CG  1 
ATOM   1353 C CD1 . LEU A 1 175 ? 6.91471   -11.25836 54.01241 1.000 28.39960 ? 177 LEU A CD1 1 
ATOM   1354 C CD2 . LEU A 1 175 ? 7.20676   -9.14994  52.67044 1.000 28.14178 ? 177 LEU A CD2 1 
ATOM   1355 N N   . GLU A 1 176 ? 12.21673  -10.26027 54.50399 1.000 32.03650 ? 178 GLU A N   1 
ATOM   1356 C CA  . GLU A 1 176 ? 13.36307  -10.72843 55.26350 1.000 36.57708 ? 178 GLU A CA  1 
ATOM   1357 C C   . GLU A 1 176 ? 13.50129  -10.00005 56.58777 1.000 32.97404 ? 178 GLU A C   1 
ATOM   1358 O O   . GLU A 1 176 ? 14.46465  -10.23847 57.32068 1.000 33.32238 ? 178 GLU A O   1 
ATOM   1359 C CB  . GLU A 1 176 ? 14.63175  -10.56334 54.42744 1.000 38.73476 ? 178 GLU A CB  1 
ATOM   1360 C CG  . GLU A 1 176 ? 14.45887  -11.17108 53.04584 1.000 44.50855 ? 178 GLU A CG  1 
ATOM   1361 C CD  . GLU A 1 176 ? 15.66486  -11.95192 52.58475 1.000 55.06152 ? 178 GLU A CD  1 
ATOM   1362 O OE1 . GLU A 1 176 ? 16.19428  -12.75362 53.38533 1.000 55.37852 ? 178 GLU A OE1 1 
ATOM   1363 O OE2 . GLU A 1 176 ? 16.07359  -11.77010 51.41556 1.000 62.31275 ? 178 GLU A OE2 1 
ATOM   1364 N N   . GLY A 1 177 ? 12.56651  -9.10919  56.89831 1.000 30.26455 ? 179 GLY A N   1 
ATOM   1365 C CA  . GLY A 1 177 ? 12.47565  -8.49997  58.20233 1.000 29.75626 ? 179 GLY A CA  1 
ATOM   1366 C C   . GLY A 1 177 ? 13.25341  -7.22541  58.41158 1.000 26.51394 ? 179 GLY A C   1 
ATOM   1367 O O   . GLY A 1 177 ? 13.35669  -6.78752  59.55843 1.000 28.38521 ? 179 GLY A O   1 
ATOM   1368 N N   . ASN A 1 178 ? 13.79886  -6.61517  57.35266 1.000 26.41010 ? 180 ASN A N   1 
ATOM   1369 C CA  . ASN A 1 178 ? 14.51907  -5.35149  57.45472 1.000 27.66968 ? 180 ASN A CA  1 
ATOM   1370 C C   . ASN A 1 178 ? 13.56351  -4.18684  57.26457 1.000 29.14600 ? 180 ASN A C   1 
ATOM   1371 O O   . ASN A 1 178 ? 12.89855  -4.09636  56.22576 1.000 25.81351 ? 180 ASN A O   1 
ATOM   1372 C CB  . ASN A 1 178 ? 15.61415  -5.24831  56.39421 1.000 31.08391 ? 180 ASN A CB  1 
ATOM   1373 C CG  . ASN A 1 178 ? 16.46432  -6.48971  56.31125 1.000 35.78059 ? 180 ASN A CG  1 
ATOM   1374 O OD1 . ASN A 1 178 ? 16.33070  -7.29967  55.37566 1.000 37.16380 ? 180 ASN A OD1 1 
ATOM   1375 N ND2 . ASN A 1 178 ? 17.35229  -6.64901  57.28199 1.000 30.88008 ? 180 ASN A ND2 1 
ATOM   1376 N N   . PHE A 1 179 ? 13.53624  -3.27082  58.23402 1.000 26.77891 ? 181 PHE A N   1 
ATOM   1377 C CA  . PHE A 1 179 ? 12.64892  -2.12199  58.10689 1.000 26.38322 ? 181 PHE A CA  1 
ATOM   1378 C C   . PHE A 1 179 ? 13.00138  -1.30132  56.87691 1.000 28.56919 ? 181 PHE A C   1 
ATOM   1379 O O   . PHE A 1 179 ? 14.16972  -1.18414  56.49441 1.000 26.46647 ? 181 PHE A O   1 
ATOM   1380 C CB  . PHE A 1 179 ? 12.70811  -1.23972  59.35681 1.000 25.90395 ? 181 PHE A CB  1 
ATOM   1381 C CG  . PHE A 1 179 ? 11.56718  -1.49147  60.30633 1.000 27.02737 ? 181 PHE A CG  1 
ATOM   1382 C CD1 . PHE A 1 179 ? 10.34317  -0.86409  60.12639 1.000 26.81760 ? 181 PHE A CD1 1 
ATOM   1383 C CD2 . PHE A 1 179 ? 11.70297  -2.40673  61.33312 1.000 27.81388 ? 181 PHE A CD2 1 
ATOM   1384 C CE1 . PHE A 1 179 ? 9.29140   -1.12139  60.97255 1.000 25.75055 ? 181 PHE A CE1 1 
ATOM   1385 C CE2 . PHE A 1 179 ? 10.65802  -2.67646  62.18180 1.000 28.85078 ? 181 PHE A CE2 1 
ATOM   1386 C CZ  . PHE A 1 179 ? 9.44990   -2.03088  62.00851 1.000 27.47030 ? 181 PHE A CZ  1 
ATOM   1387 N N   . TYR A 1 180 ? 11.97619  -0.75151  56.23528 1.000 27.03725 ? 182 TYR A N   1 
ATOM   1388 C CA  . TYR A 1 180 ? 12.19110  0.36123   55.32576 1.000 23.14992 ? 182 TYR A CA  1 
ATOM   1389 C C   . TYR A 1 180 ? 12.34263  1.60809   56.18074 1.000 24.65907 ? 182 TYR A C   1 
ATOM   1390 O O   . TYR A 1 180 ? 11.44344  1.93952   56.95702 1.000 25.05408 ? 182 TYR A O   1 
ATOM   1391 C CB  . TYR A 1 180 ? 11.02129  0.51034   54.36021 1.000 25.45622 ? 182 TYR A CB  1 
ATOM   1392 C CG  . TYR A 1 180 ? 10.94257  -0.56885  53.30164 1.000 28.00039 ? 182 TYR A CG  1 
ATOM   1393 C CD1 . TYR A 1 180 ? 11.76641  -0.54159  52.17429 1.000 29.46241 ? 182 TYR A CD1 1 
ATOM   1394 C CD2 . TYR A 1 180 ? 10.04862  -1.61378  53.43255 1.000 26.89032 ? 182 TYR A CD2 1 
ATOM   1395 C CE1 . TYR A 1 180 ? 11.69190  -1.53663  51.20995 1.000 29.89787 ? 182 TYR A CE1 1 
ATOM   1396 C CE2 . TYR A 1 180 ? 9.95773   -2.60432  52.47004 1.000 28.33676 ? 182 TYR A CE2 1 
ATOM   1397 C CZ  . TYR A 1 180 ? 10.78394  -2.56275  51.36179 1.000 28.93603 ? 182 TYR A CZ  1 
ATOM   1398 O OH  . TYR A 1 180 ? 10.67631  -3.55428  50.41364 1.000 29.51182 ? 182 TYR A OH  1 
ATOM   1399 N N   . GLY A 1 181 ? 13.46981  2.29522   56.06441 1.000 26.07877 ? 183 GLY A N   1 
ATOM   1400 C CA  . GLY A 1 181 ? 13.64053  3.51977   56.81334 1.000 26.55017 ? 183 GLY A CA  1 
ATOM   1401 C C   . GLY A 1 181 ? 14.19590  3.33948   58.20777 1.000 28.30840 ? 183 GLY A C   1 
ATOM   1402 O O   . GLY A 1 181 ? 14.46288  2.22179   58.66963 1.000 30.16331 ? 183 GLY A O   1 
ATOM   1403 N N   . PRO A 1 182 ? 14.36494  4.45227   58.92314 1.000 30.71908 ? 184 PRO A N   1 
ATOM   1404 C CA  . PRO A 1 182 ? 15.10248  4.41129   60.19229 1.000 30.53363 ? 184 PRO A CA  1 
ATOM   1405 C C   . PRO A 1 182 ? 14.28534  3.93573   61.38230 1.000 36.47555 ? 184 PRO A C   1 
ATOM   1406 O O   . PRO A 1 182 ? 14.56453  4.36134   62.50442 1.000 39.40932 ? 184 PRO A O   1 
ATOM   1407 C CB  . PRO A 1 182 ? 15.50766  5.87428   60.38588 1.000 31.04188 ? 184 PRO A CB  1 
ATOM   1408 C CG  . PRO A 1 182 ? 14.40003  6.62825   59.78703 1.000 31.38131 ? 184 PRO A CG  1 
ATOM   1409 C CD  . PRO A 1 182 ? 13.89375  5.81396   58.60995 1.000 31.58525 ? 184 PRO A CD  1 
ATOM   1410 N N   . PHE A 1 183 ? 13.28130  3.08760   61.18749 1.000 30.91853 ? 185 PHE A N   1 
ATOM   1411 C CA  . PHE A 1 183 ? 12.33682  2.81305   62.26113 1.000 29.64843 ? 185 PHE A CA  1 
ATOM   1412 C C   . PHE A 1 183 ? 12.64511  1.49432   62.95623 1.000 33.45075 ? 185 PHE A C   1 
ATOM   1413 O O   . PHE A 1 183 ? 13.35349  0.64127   62.42424 1.000 33.06135 ? 185 PHE A O   1 
ATOM   1414 C CB  . PHE A 1 183 ? 10.91109  2.81161   61.71978 1.000 30.10153 ? 185 PHE A CB  1 
ATOM   1415 C CG  . PHE A 1 183 ? 10.61371  3.99561   60.84976 1.000 30.81549 ? 185 PHE A CG  1 
ATOM   1416 C CD1 . PHE A 1 183 ? 10.63075  5.27765   61.38944 1.000 29.66287 ? 185 PHE A CD1 1 
ATOM   1417 C CD2 . PHE A 1 183 ? 10.34766  3.83833   59.50425 1.000 26.31814 ? 185 PHE A CD2 1 
ATOM   1418 C CE1 . PHE A 1 183 ? 10.37231  6.38218   60.59607 1.000 34.31277 ? 185 PHE A CE1 1 
ATOM   1419 C CE2 . PHE A 1 183 ? 10.09121  4.93217   58.70877 1.000 30.99613 ? 185 PHE A CE2 1 
ATOM   1420 C CZ  . PHE A 1 183 ? 10.10177  6.21034   59.25112 1.000 32.23786 ? 185 PHE A CZ  1 
ATOM   1421 N N   . PHE A 1 184 ? 12.09181  1.34823   64.16750 1.000 33.36511 ? 186 PHE A N   1 
ATOM   1422 C CA  . PHE A 1 184 ? 12.31843  0.21503   65.05768 1.000 30.79832 ? 186 PHE A CA  1 
ATOM   1423 C C   . PHE A 1 184 ? 10.98947  -0.25582  65.62853 1.000 33.18221 ? 186 PHE A C   1 
ATOM   1424 O O   . PHE A 1 184 ? 10.08646  0.55840   65.87194 1.000 30.03904 ? 186 PHE A O   1 
ATOM   1425 C CB  . PHE A 1 184 ? 13.24997  0.60501   66.22037 1.000 37.57037 ? 186 PHE A CB  1 
ATOM   1426 C CG  . PHE A 1 184 ? 14.61939  1.00727   65.77382 1.000 46.76233 ? 186 PHE A CG  1 
ATOM   1427 C CD1 . PHE A 1 184 ? 15.60863  0.04714   65.57848 1.000 47.00847 ? 186 PHE A CD1 1 
ATOM   1428 C CD2 . PHE A 1 184 ? 14.91541  2.34330   65.51632 1.000 45.57777 ? 186 PHE A CD2 1 
ATOM   1429 C CE1 . PHE A 1 184 ? 16.87990  0.40925   65.14857 1.000 50.21100 ? 186 PHE A CE1 1 
ATOM   1430 C CE2 . PHE A 1 184 ? 16.18571  2.71493   65.07850 1.000 49.70366 ? 186 PHE A CE2 1 
ATOM   1431 C CZ  . PHE A 1 184 ? 17.16988  1.73998   64.89618 1.000 50.49099 ? 186 PHE A CZ  1 
ATOM   1432 N N   . ASP A 1 185 ? 10.87517  -1.57254  65.86707 1.000 26.72109 ? 187 ASP A N   1 
ATOM   1433 C CA  . ASP A 1 185 ? 9.63350   -2.12898  66.42345 1.000 29.37216 ? 187 ASP A CA  1 
ATOM   1434 C C   . ASP A 1 185 ? 9.66762   -2.04141  67.95310 1.000 31.91303 ? 187 ASP A C   1 
ATOM   1435 O O   . ASP A 1 185 ? 9.72933   -3.03077  68.69295 1.000 28.56734 ? 187 ASP A O   1 
ATOM   1436 C CB  . ASP A 1 185 ? 9.37569   -3.55277  65.92101 1.000 28.57793 ? 187 ASP A CB  1 
ATOM   1437 C CG  . ASP A 1 185 ? 10.59052  -4.48368  66.02849 1.000 32.45340 ? 187 ASP A CG  1 
ATOM   1438 O OD1 . ASP A 1 185 ? 11.69923  -4.05359  66.41723 1.000 32.78197 ? 187 ASP A OD1 1 
ATOM   1439 O OD2 . ASP A 1 185 ? 10.43210  -5.68429  65.71930 1.000 28.17486 ? 187 ASP A OD2 1 
ATOM   1440 N N   . ARG A 1 186 ? 9.61754   -0.80172  68.42248 1.000 28.52502 ? 188 ARG A N   1 
ATOM   1441 C CA  . ARG A 1 186 ? 9.48783   -0.50317  69.83857 1.000 32.71483 ? 188 ARG A CA  1 
ATOM   1442 C C   . ARG A 1 186 ? 8.64679   0.75741   69.98773 1.000 35.74668 ? 188 ARG A C   1 
ATOM   1443 O O   . ARG A 1 186 ? 8.55965   1.57591   69.06924 1.000 32.82095 ? 188 ARG A O   1 
ATOM   1444 C CB  . ARG A 1 186 ? 10.86511  -0.34695  70.52231 1.000 35.25414 ? 188 ARG A CB  1 
ATOM   1445 C CG  . ARG A 1 186 ? 11.75215  0.74340   69.97083 1.000 38.08677 ? 188 ARG A CG  1 
ATOM   1446 C CD  . ARG A 1 186 ? 12.99813  0.97743   70.85844 1.000 50.67918 ? 188 ARG A CD  1 
ATOM   1447 N NE  . ARG A 1 186 ? 14.17748  0.24502   70.38369 1.000 62.51448 ? 188 ARG A NE  1 
ATOM   1448 C CZ  . ARG A 1 186 ? 15.30017  0.81866   69.94453 1.000 60.54942 ? 188 ARG A CZ  1 
ATOM   1449 N NH1 . ARG A 1 186 ? 15.40437  2.14151   69.91523 1.000 61.32718 ? 188 ARG A NH1 1 
ATOM   1450 N NH2 . ARG A 1 186 ? 16.31948  0.07176   69.52727 1.000 56.16624 ? 188 ARG A NH2 1 
ATOM   1451 N N   . GLN A 1 187 ? 7.99694   0.89399   71.13885 1.000 34.12014 ? 189 GLN A N   1 
ATOM   1452 C CA  . GLN A 1 187 ? 7.12142   2.03818   71.37690 1.000 37.31730 ? 189 GLN A CA  1 
ATOM   1453 C C   . GLN A 1 187 ? 7.98894   3.16779   71.89439 1.000 41.70982 ? 189 GLN A C   1 
ATOM   1454 O O   . GLN A 1 187 ? 8.15231   3.35926   73.10192 1.000 46.75668 ? 189 GLN A O   1 
ATOM   1455 C CB  . GLN A 1 187 ? 6.01657   1.68225   72.35880 1.000 38.46409 ? 189 GLN A CB  1 
ATOM   1456 C CG  . GLN A 1 187 ? 5.00254   2.78060   72.59049 1.000 38.38090 ? 189 GLN A CG  1 
ATOM   1457 C CD  . GLN A 1 187 ? 3.76000   2.24736   73.27744 1.000 44.27146 ? 189 GLN A CD  1 
ATOM   1458 O OE1 . GLN A 1 187 ? 3.34627   1.10918   73.03805 1.000 45.13902 ? 189 GLN A OE1 1 
ATOM   1459 N NE2 . GLN A 1 187 ? 3.17291   3.05235   74.15261 1.000 38.15458 ? 189 GLN A NE2 1 
ATOM   1460 N N   . THR A 1 188 ? 8.59575   3.89558   70.96425 1.000 42.65793 ? 190 THR A N   1 
ATOM   1461 C CA  . THR A 1 188 ? 9.38519   5.07045   71.28989 1.000 44.92807 ? 190 THR A CA  1 
ATOM   1462 C C   . THR A 1 188 ? 9.10797   6.14476   70.25321 1.000 45.69088 ? 190 THR A C   1 
ATOM   1463 O O   . THR A 1 188 ? 8.52887   5.88723   69.18965 1.000 39.43668 ? 190 THR A O   1 
ATOM   1464 C CB  . THR A 1 188 ? 10.88836  4.76780   71.33830 1.000 45.98656 ? 190 THR A CB  1 
ATOM   1465 O OG1 . THR A 1 188 ? 11.58713  5.95746   71.71139 1.000 59.62340 ? 190 THR A OG1 1 
ATOM   1466 C CG2 . THR A 1 188 ? 11.37971  4.35497   69.98099 1.000 42.59770 ? 190 THR A CG2 1 
ATOM   1467 N N   . ALA A 1 189 ? 9.53650   7.36340   70.57995 1.000 50.58766 ? 191 ALA A N   1 
ATOM   1468 C CA  . ALA A 1 189 ? 9.41231   8.49200   69.66315 1.000 47.42929 ? 191 ALA A CA  1 
ATOM   1469 C C   . ALA A 1 189 ? 10.28024  8.25338   68.43614 1.000 43.73869 ? 191 ALA A C   1 
ATOM   1470 O O   . ALA A 1 189 ? 11.50185  8.10674   68.55521 1.000 45.31354 ? 191 ALA A O   1 
ATOM   1471 C CB  . ALA A 1 189 ? 9.82168   9.78833   70.36525 1.000 48.21654 ? 191 ALA A CB  1 
ATOM   1472 N N   . GLN A 1 190 ? 9.65515   8.19992   67.25807 1.000 43.67701 ? 192 GLN A N   1 
ATOM   1473 C CA  . GLN A 1 190 ? 10.37737  7.94949   66.01668 1.000 40.36269 ? 192 GLN A CA  1 
ATOM   1474 C C   . GLN A 1 190 ? 9.87158   8.89999   64.95218 1.000 42.29881 ? 192 GLN A C   1 
ATOM   1475 O O   . GLN A 1 190 ? 8.68897   8.87456   64.59928 1.000 47.16859 ? 192 GLN A O   1 
ATOM   1476 C CB  . GLN A 1 190 ? 10.21147  6.50527   65.55698 1.000 40.15308 ? 192 GLN A CB  1 
ATOM   1477 C CG  . GLN A 1 190 ? 10.82568  5.52851   66.49016 1.000 39.17073 ? 192 GLN A CG  1 
ATOM   1478 C CD  . GLN A 1 190 ? 10.58711  4.11792   66.03688 1.000 37.72477 ? 192 GLN A CD  1 
ATOM   1479 O OE1 . GLN A 1 190 ? 11.05377  3.71269   64.97941 1.000 33.64336 ? 192 GLN A OE1 1 
ATOM   1480 N NE2 . GLN A 1 190 ? 9.83330   3.36962   66.82103 1.000 34.73817 ? 192 GLN A NE2 1 
ATOM   1481 N N   . ALA A 1 191 ? 10.76200  9.72976   64.43690 1.000 45.19728 ? 193 ALA A N   1 
ATOM   1482 C CA  . ALA A 1 191 ? 10.39473  10.67278  63.39637 1.000 47.87790 ? 193 ALA A CA  1 
ATOM   1483 C C   . ALA A 1 191 ? 10.77118  10.10892  62.03504 1.000 35.81223 ? 193 ALA A C   1 
ATOM   1484 O O   . ALA A 1 191 ? 11.83869  9.51954   61.86826 1.000 35.39386 ? 193 ALA A O   1 
ATOM   1485 C CB  . ALA A 1 191 ? 11.07191  12.02948  63.61744 1.000 45.50578 ? 193 ALA A CB  1 
ATOM   1486 N N   . ALA A 1 192 ? 9.87546   10.27059  61.07037 1.000 40.80392 ? 194 ALA A N   1 
ATOM   1487 C CA  . ALA A 1 192 ? 10.25334  10.05172  59.68711 1.000 41.98287 ? 194 ALA A CA  1 
ATOM   1488 C C   . ALA A 1 192 ? 10.97949  11.29227  59.17183 1.000 42.92843 ? 194 ALA A C   1 
ATOM   1489 O O   . ALA A 1 192 ? 10.85323  12.38946  59.72102 1.000 43.26031 ? 194 ALA A O   1 
ATOM   1490 C CB  . ALA A 1 192 ? 9.02496   9.76097   58.82628 1.000 36.02101 ? 194 ALA A CB  1 
ATOM   1491 N N   . GLY A 1 193 ? 11.76410  11.12280  58.12066 1.000 40.19838 ? 195 GLY A N   1 
ATOM   1492 C CA  . GLY A 1 193 ? 12.39230  12.33073  57.59981 1.000 46.87637 ? 195 GLY A CA  1 
ATOM   1493 C C   . GLY A 1 193 ? 11.36874  13.27951  57.00516 1.000 40.83524 ? 195 GLY A C   1 
ATOM   1494 O O   . GLY A 1 193 ? 10.17257  12.95510  56.97378 1.000 34.59473 ? 195 GLY A O   1 
ATOM   1495 N N   . THR A 1 194 ? 11.80596  14.44745  56.53286 1.000 40.58424 ? 196 THR A N   1 
ATOM   1496 C CA  . THR A 1 194 ? 10.92728  15.25994  55.70297 1.000 36.94676 ? 196 THR A CA  1 
ATOM   1497 C C   . THR A 1 194 ? 10.50569  14.47088  54.46622 1.000 34.62273 ? 196 THR A C   1 
ATOM   1498 O O   . THR A 1 194 ? 11.34462  13.91226  53.76031 1.000 37.55391 ? 196 THR A O   1 
ATOM   1499 C CB  . THR A 1 194 ? 11.61219  16.54807  55.25757 1.000 35.35006 ? 196 THR A CB  1 
ATOM   1500 O OG1 . THR A 1 194 ? 12.01388  17.31083  56.39999 1.000 41.22790 ? 196 THR A OG1 1 
ATOM   1501 C CG2 . THR A 1 194 ? 10.63611  17.36379  54.42915 1.000 37.42063 ? 196 THR A CG2 1 
ATOM   1502 N N   . ASP A 1 195 ? 9.20323   14.45448  54.20250 1.000 32.67121 ? 197 ASP A N   1 
ATOM   1503 C CA  . ASP A 1 195 ? 8.63073   13.78857  53.03737 1.000 34.97288 ? 197 ASP A CA  1 
ATOM   1504 C C   . ASP A 1 195 ? 8.72960   14.69558  51.81112 1.000 39.24293 ? 197 ASP A C   1 
ATOM   1505 O O   . ASP A 1 195 ? 8.43103   15.88977  51.89069 1.000 42.37943 ? 197 ASP A O   1 
ATOM   1506 C CB  . ASP A 1 195 ? 7.17067   13.44778  53.33481 1.000 35.13671 ? 197 ASP A CB  1 
ATOM   1507 C CG  . ASP A 1 195 ? 6.59339   12.41678  52.38445 1.000 42.33179 ? 197 ASP A CG  1 
ATOM   1508 O OD1 . ASP A 1 195 ? 7.36081   11.82711  51.59911 1.000 37.63766 ? 197 ASP A OD1 1 
ATOM   1509 O OD2 . ASP A 1 195 ? 5.35899   12.20806  52.41964 1.000 45.84132 ? 197 ASP A OD2 1 
ATOM   1510 N N   . THR A 1 196 ? 9.16140   14.14645  50.68298 1.000 35.58036 ? 198 THR A N   1 
ATOM   1511 C CA  . THR A 1 196 ? 9.22692   14.92112  49.45051 1.000 36.77041 ? 198 THR A CA  1 
ATOM   1512 C C   . THR A 1 196 ? 8.29332   14.32131  48.39759 1.000 33.59727 ? 198 THR A C   1 
ATOM   1513 O O   . THR A 1 196 ? 7.73012   13.23899  48.57729 1.000 35.74289 ? 198 THR A O   1 
ATOM   1514 C CB  . THR A 1 196 ? 10.67185  15.00664  48.93395 1.000 41.05451 ? 198 THR A CB  1 
ATOM   1515 O OG1 . THR A 1 196 ? 11.14354  13.69981  48.61248 1.000 34.80915 ? 198 THR A OG1 1 
ATOM   1516 C CG2 . THR A 1 196 ? 11.59856  15.61625  50.00272 1.000 40.98818 ? 198 THR A CG2 1 
ATOM   1517 N N   . THR A 1 197 ? 8.10608   15.05014  47.29761 1.000 32.06289 ? 199 THR A N   1 
ATOM   1518 C CA  . THR A 1 197 ? 7.19806   14.62895  46.23514 1.000 32.91315 ? 199 THR A CA  1 
ATOM   1519 C C   . THR A 1 197 ? 7.98255   13.85675  45.18542 1.000 34.02611 ? 199 THR A C   1 
ATOM   1520 O O   . THR A 1 197 ? 9.08963   14.25735  44.81563 1.000 33.64304 ? 199 THR A O   1 
ATOM   1521 C CB  . THR A 1 197 ? 6.49772   15.82860  45.59533 1.000 35.59347 ? 199 THR A CB  1 
ATOM   1522 O OG1 . THR A 1 197 ? 5.74026   16.52580  46.59215 1.000 34.70670 ? 199 THR A OG1 1 
ATOM   1523 C CG2 . THR A 1 197 ? 5.54439   15.37326  44.49531 1.000 31.70563 ? 199 THR A CG2 1 
ATOM   1524 N N   . ILE A 1 198 ? 7.40952   12.74862  44.71445 1.000 33.87323 ? 200 ILE A N   1 
ATOM   1525 C CA  . ILE A 1 198 ? 8.08403   11.83912  43.78718 1.000 30.13437 ? 200 ILE A CA  1 
ATOM   1526 C C   . ILE A 1 198 ? 7.94988   12.42719  42.38694 1.000 32.91520 ? 200 ILE A C   1 
ATOM   1527 O O   . ILE A 1 198 ? 6.93704   12.21172  41.71629 1.000 28.25801 ? 200 ILE A O   1 
ATOM   1528 C CB  . ILE A 1 198 ? 7.50371   10.42738  43.84560 1.000 31.76615 ? 200 ILE A CB  1 
ATOM   1529 C CG1 . ILE A 1 198 ? 7.53836   9.88786   45.27903 1.000 28.98528 ? 200 ILE A CG1 1 
ATOM   1530 C CG2 . ILE A 1 198 ? 8.25842   9.54006   42.87895 1.000 29.80436 ? 200 ILE A CG2 1 
ATOM   1531 C CD1 . ILE A 1 198 ? 6.44116   8.85357   45.55502 1.000 32.14266 ? 200 ILE A CD1 1 
ATOM   1532 N N   . THR A 1 199 ? 8.98624   13.13893  41.93210 1.000 31.23761 ? 201 THR A N   1 
ATOM   1533 C CA  . THR A 1 199 ? 8.87791   13.93327  40.70895 1.000 31.64475 ? 201 THR A CA  1 
ATOM   1534 C C   . THR A 1 199 ? 8.53453   13.07673  39.49222 1.000 28.90245 ? 201 THR A C   1 
ATOM   1535 O O   . THR A 1 199 ? 7.64214   13.42895  38.71274 1.000 26.70796 ? 201 THR A O   1 
ATOM   1536 C CB  . THR A 1 199 ? 10.17599  14.69709  40.47735 1.000 30.24204 ? 201 THR A CB  1 
ATOM   1537 O OG1 . THR A 1 199 ? 10.46645  15.47448  41.64880 1.000 36.23087 ? 201 THR A OG1 1 
ATOM   1538 C CG2 . THR A 1 199 ? 10.06278  15.61039  39.24288 1.000 29.02320 ? 201 THR A CG2 1 
ATOM   1539 N N   . VAL A 1 200 ? 9.23809   11.95621  39.30091 1.000 25.30017 ? 202 VAL A N   1 
ATOM   1540 C CA  . VAL A 1 200 ? 8.98896   11.13820  38.10871 1.000 30.00382 ? 202 VAL A CA  1 
ATOM   1541 C C   . VAL A 1 200 ? 7.54343   10.64392  38.08264 1.000 26.27213 ? 202 VAL A C   1 
ATOM   1542 O O   . VAL A 1 200 ? 6.94064   10.53141  37.01188 1.000 28.17023 ? 202 VAL A O   1 
ATOM   1543 C CB  . VAL A 1 200 ? 9.99849   9.97180   38.02434 1.000 30.17075 ? 202 VAL A CB  1 
ATOM   1544 C CG1 . VAL A 1 200 ? 9.83556   9.02339   39.22327 1.000 29.50936 ? 202 VAL A CG1 1 
ATOM   1545 C CG2 . VAL A 1 200 ? 9.85883   9.21667   36.69578 1.000 28.06753 ? 202 VAL A CG2 1 
ATOM   1546 N N   . ASN A 1 201 ? 6.95499   10.38950  39.25513 1.000 26.82728 ? 203 ASN A N   1 
ATOM   1547 C CA  . ASN A 1 201 ? 5.56667   9.94201   39.32024 1.000 26.40951 ? 203 ASN A CA  1 
ATOM   1548 C C   . ASN A 1 201 ? 4.59658   11.05790  38.95433 1.000 26.31924 ? 203 ASN A C   1 
ATOM   1549 O O   . ASN A 1 201 ? 3.60023   10.80415  38.27422 1.000 24.38527 ? 203 ASN A O   1 
ATOM   1550 C CB  . ASN A 1 201 ? 5.25518   9.40531   40.71814 1.000 29.31340 ? 203 ASN A CB  1 
ATOM   1551 C CG  . ASN A 1 201 ? 5.85565   8.01468   40.96191 1.000 30.39173 ? 203 ASN A CG  1 
ATOM   1552 O OD1 . ASN A 1 201 ? 6.63809   7.51195   40.14605 1.000 30.45519 ? 203 ASN A OD1 1 
ATOM   1553 N ND2 . ASN A 1 201 ? 5.49520   7.39548   42.08127 1.000 27.71254 ? 203 ASN A ND2 1 
ATOM   1554 N N   . VAL A 1 202 ? 4.85464   12.30129  39.39785 1.000 26.11867 ? 204 VAL A N   1 
ATOM   1555 C CA  . VAL A 1 202 ? 3.99327   13.40860  38.96911 1.000 27.51901 ? 204 VAL A CA  1 
ATOM   1556 C C   . VAL A 1 202 ? 4.04306   13.55345  37.45654 1.000 23.71079 ? 204 VAL A C   1 
ATOM   1557 O O   . VAL A 1 202 ? 3.01509   13.74596  36.80137 1.000 24.39022 ? 204 VAL A O   1 
ATOM   1558 C CB  . VAL A 1 202 ? 4.38363   14.73291  39.66243 1.000 25.25573 ? 204 VAL A CB  1 
ATOM   1559 C CG1 . VAL A 1 202 ? 3.54252   15.88458  39.11556 1.000 27.93853 ? 204 VAL A CG1 1 
ATOM   1560 C CG2 . VAL A 1 202 ? 4.20997   14.63596  41.15589 1.000 26.77675 ? 204 VAL A CG2 1 
ATOM   1561 N N   . LEU A 1 203 ? 5.23964   13.45461  36.87291 1.000 24.64051 ? 205 LEU A N   1 
ATOM   1562 C CA  . LEU A 1 203 ? 5.35013   13.53687  35.41982 1.000 28.07686 ? 205 LEU A CA  1 
ATOM   1563 C C   . LEU A 1 203 ? 4.54840   12.43514  34.72453 1.000 27.44502 ? 205 LEU A C   1 
ATOM   1564 O O   . LEU A 1 203 ? 3.88028   12.69140  33.71610 1.000 27.52120 ? 205 LEU A O   1 
ATOM   1565 C CB  . LEU A 1 203 ? 6.82322   13.47656  35.01135 1.000 31.89797 ? 205 LEU A CB  1 
ATOM   1566 C CG  . LEU A 1 203 ? 7.59622   14.73598  35.39683 1.000 26.18593 ? 205 LEU A CG  1 
ATOM   1567 C CD1 . LEU A 1 203 ? 9.09797   14.50346  35.22700 1.000 27.70429 ? 205 LEU A CD1 1 
ATOM   1568 C CD2 . LEU A 1 203 ? 7.13079   15.93113  34.57370 1.000 25.08091 ? 205 LEU A CD2 1 
ATOM   1569 N N   . ALA A 1 204 ? 4.60653   11.20179  35.23971 1.000 25.88374 ? 206 ALA A N   1 
ATOM   1570 C CA  . ALA A 1 204 ? 3.81861   10.11233  34.65438 1.000 26.02287 ? 206 ALA A CA  1 
ATOM   1571 C C   . ALA A 1 204 ? 2.32853   10.41850  34.69087 1.000 25.64839 ? 206 ALA A C   1 
ATOM   1572 O O   . ALA A 1 204 ? 1.59199   10.08976  33.75290 1.000 30.12077 ? 206 ALA A O   1 
ATOM   1573 C CB  . ALA A 1 204 ? 4.08547   8.80419   35.40413 1.000 28.62684 ? 206 ALA A CB  1 
ATOM   1574 N N   . TRP A 1 205 ? 1.86803   11.01727  35.78203 1.000 26.15591 ? 207 TRP A N   1 
ATOM   1575 C CA  . TRP A 1 205 ? 0.45524   11.33234  35.94632 1.000 28.70129 ? 207 TRP A CA  1 
ATOM   1576 C C   . TRP A 1 205 ? 0.01232   12.48019  35.03044 1.000 26.29208 ? 207 TRP A C   1 
ATOM   1577 O O   . TRP A 1 205 ? -1.11637  12.46500  34.52461 1.000 28.09873 ? 207 TRP A O   1 
ATOM   1578 C CB  . TRP A 1 205 ? 0.21924   11.64396  37.42481 1.000 27.29740 ? 207 TRP A CB  1 
ATOM   1579 C CG  . TRP A 1 205 ? -1.15053  12.10770  37.81198 1.000 33.52716 ? 207 TRP A CG  1 
ATOM   1580 C CD1 . TRP A 1 205 ? -2.25799  11.33148  38.04166 1.000 34.90172 ? 207 TRP A CD1 1 
ATOM   1581 C CD2 . TRP A 1 205 ? -1.54955  13.46018  38.06265 1.000 33.35442 ? 207 TRP A CD2 1 
ATOM   1582 N NE1 . TRP A 1 205 ? -3.32335  12.12856  38.41077 1.000 33.72960 ? 207 TRP A NE1 1 
ATOM   1583 C CE2 . TRP A 1 205 ? -2.91392  13.43585  38.42691 1.000 33.29141 ? 207 TRP A CE2 1 
ATOM   1584 C CE3 . TRP A 1 205 ? -0.88971  14.69191  37.99608 1.000 33.34843 ? 207 TRP A CE3 1 
ATOM   1585 C CZ2 . TRP A 1 205 ? -3.62314  14.59243  38.73667 1.000 34.95641 ? 207 TRP A CZ2 1 
ATOM   1586 C CZ3 . TRP A 1 205 ? -1.59919  15.84032  38.30096 1.000 36.47748 ? 207 TRP A CZ3 1 
ATOM   1587 C CH2 . TRP A 1 205 ? -2.95082  15.78174  38.66413 1.000 39.56686 ? 207 TRP A CH2 1 
ATOM   1588 N N   . LEU A 1 206 ? 0.88264   13.47062  34.78632 1.000 30.11089 ? 208 LEU A N   1 
ATOM   1589 C CA  . LEU A 1 206 ? 0.58866   14.47349  33.75552 1.000 29.97978 ? 208 LEU A CA  1 
ATOM   1590 C C   . LEU A 1 206 ? 0.48359   13.82810  32.37900 1.000 30.04888 ? 208 LEU A C   1 
ATOM   1591 O O   . LEU A 1 206 ? -0.36154  14.21708  31.56414 1.000 33.28615 ? 208 LEU A O   1 
ATOM   1592 C CB  . LEU A 1 206 ? 1.65965   15.56570  33.74458 1.000 29.68628 ? 208 LEU A CB  1 
ATOM   1593 C CG  . LEU A 1 206 ? 1.67605   16.37683  35.03777 1.000 27.66621 ? 208 LEU A CG  1 
ATOM   1594 C CD1 . LEU A 1 206 ? 2.94452   17.22104  35.13454 1.000 31.19241 ? 208 LEU A CD1 1 
ATOM   1595 C CD2 . LEU A 1 206 ? 0.43822   17.25016  35.13597 1.000 32.46959 ? 208 LEU A CD2 1 
ATOM   1596 N N   . TYR A 1 207 ? 1.33643   12.84072  32.09495 1.000 27.87562 ? 209 TYR A N   1 
ATOM   1597 C CA  . TYR A 1 207 ? 1.17416   12.09274  30.85547 1.000 28.01562 ? 209 TYR A CA  1 
ATOM   1598 C C   . TYR A 1 207 ? -0.15901  11.35882  30.83311 1.000 29.65202 ? 209 TYR A C   1 
ATOM   1599 O O   . TYR A 1 207 ? -0.84665  11.34021  29.80481 1.000 31.55824 ? 209 TYR A O   1 
ATOM   1600 C CB  . TYR A 1 207 ? 2.32624   11.11669  30.66925 1.000 27.24932 ? 209 TYR A CB  1 
ATOM   1601 C CG  . TYR A 1 207 ? 3.55028   11.71534  30.05267 1.000 27.05311 ? 209 TYR A CG  1 
ATOM   1602 C CD1 . TYR A 1 207 ? 3.54644   12.15102  28.73174 1.000 32.67268 ? 209 TYR A CD1 1 
ATOM   1603 C CD2 . TYR A 1 207 ? 4.72452   11.83075  30.78071 1.000 28.60366 ? 209 TYR A CD2 1 
ATOM   1604 C CE1 . TYR A 1 207 ? 4.68120   12.69780  28.15143 1.000 29.23046 ? 209 TYR A CE1 1 
ATOM   1605 C CE2 . TYR A 1 207 ? 5.85597   12.36852  30.21133 1.000 31.07574 ? 209 TYR A CE2 1 
ATOM   1606 C CZ  . TYR A 1 207 ? 5.82334   12.81088  28.90123 1.000 32.15690 ? 209 TYR A CZ  1 
ATOM   1607 O OH  . TYR A 1 207 ? 6.95091   13.34919  28.34420 1.000 32.05309 ? 209 TYR A OH  1 
ATOM   1608 N N   . ALA A 1 208 ? -0.53434  10.72906  31.94928 1.000 33.37018 ? 210 ALA A N   1 
ATOM   1609 C CA  . ALA A 1 208 ? -1.84508  10.08105  32.01613 1.000 31.14644 ? 210 ALA A CA  1 
ATOM   1610 C C   . ALA A 1 208 ? -2.95184  11.07608  31.71975 1.000 32.28702 ? 210 ALA A C   1 
ATOM   1611 O O   . ALA A 1 208 ? -3.94508  10.74036  31.05996 1.000 32.39103 ? 210 ALA A O   1 
ATOM   1612 C CB  . ALA A 1 208 ? -2.05801  9.46223   33.39391 1.000 33.53227 ? 210 ALA A CB  1 
ATOM   1613 N N   . ALA A 1 209 ? -2.79165  12.31004  32.21080 1.000 30.19449 ? 211 ALA A N   1 
ATOM   1614 C CA  . ALA A 1 209 ? -3.76926  13.35667  31.96184 1.000 33.30750 ? 211 ALA A CA  1 
ATOM   1615 C C   . ALA A 1 209 ? -3.85173  13.67118  30.47683 1.000 36.73857 ? 211 ALA A C   1 
ATOM   1616 O O   . ALA A 1 209 ? -4.94417  13.72732  29.90756 1.000 39.01444 ? 211 ALA A O   1 
ATOM   1617 C CB  . ALA A 1 209 ? -3.40080  14.60749  32.75581 1.000 34.41916 ? 211 ALA A CB  1 
ATOM   1618 N N   . VAL A 1 210 ? -2.69523  13.85964  29.83292 1.000 36.73491 ? 212 VAL A N   1 
ATOM   1619 C CA  . VAL A 1 210 ? -2.65175  14.08440  28.38894 1.000 37.85953 ? 212 VAL A CA  1 
ATOM   1620 C C   . VAL A 1 210 ? -3.29533  12.91665  27.64480 1.000 39.11589 ? 212 VAL A C   1 
ATOM   1621 O O   . VAL A 1 210 ? -4.10816  13.11223  26.73041 1.000 39.71428 ? 212 VAL A O   1 
ATOM   1622 C CB  . VAL A 1 210 ? -1.19483  14.32914  27.93467 1.000 38.19506 ? 212 VAL A CB  1 
ATOM   1623 C CG1 . VAL A 1 210 ? -1.08393  14.29284  26.40061 1.000 39.96898 ? 212 VAL A CG1 1 
ATOM   1624 C CG2 . VAL A 1 210 ? -0.65526  15.67424  28.50078 1.000 32.74139 ? 212 VAL A CG2 1 
ATOM   1625 N N   . ILE A 1 211 ? -2.96420  11.68439  28.03319 1.000 36.72516 ? 213 ILE A N   1 
ATOM   1626 C CA  . ILE A 1 211 ? -3.55814  10.52913  27.36521 1.000 35.34238 ? 213 ILE A CA  1 
ATOM   1627 C C   . ILE A 1 211 ? -5.08047  10.56183  27.48928 1.000 38.39089 ? 213 ILE A C   1 
ATOM   1628 O O   . ILE A 1 211 ? -5.80511  10.18571  26.55896 1.000 38.11588 ? 213 ILE A O   1 
ATOM   1629 C CB  . ILE A 1 211 ? -2.95418  9.23222   27.92986 1.000 35.80021 ? 213 ILE A CB  1 
ATOM   1630 C CG1 . ILE A 1 211 ? -1.53526  9.04085   27.39605 1.000 34.03813 ? 213 ILE A CG1 1 
ATOM   1631 C CG2 . ILE A 1 211 ? -3.82329  8.03789   27.59596 1.000 40.02449 ? 213 ILE A CG2 1 
ATOM   1632 C CD1 . ILE A 1 211 ? -0.77729  7.95463   28.11081 1.000 38.21119 ? 213 ILE A CD1 1 
ATOM   1633 N N   . ASN A 1 212 ? -5.59051  11.04198  28.62279 1.000 38.13496 ? 214 ASN A N   1 
ATOM   1634 C CA  . ASN A 1 212 ? -7.02423  11.11960  28.87028 1.000 40.05701 ? 214 ASN A CA  1 
ATOM   1635 C C   . ASN A 1 212 ? -7.62415  12.47532  28.48707 1.000 41.57855 ? 214 ASN A C   1 
ATOM   1636 O O   . ASN A 1 212 ? -8.72693  12.80284  28.93889 1.000 44.83692 ? 214 ASN A O   1 
ATOM   1637 C CB  . ASN A 1 212 ? -7.32528  10.82340  30.33929 1.000 38.34740 ? 214 ASN A CB  1 
ATOM   1638 C CG  . ASN A 1 212 ? -7.23752  9.34000   30.67244 1.000 44.56316 ? 214 ASN A CG  1 
ATOM   1639 O OD1 . ASN A 1 212 ? -8.25836  8.67688   30.81633 1.000 50.61350 ? 214 ASN A OD1 1 
ATOM   1640 N ND2 . ASN A 1 212 ? -6.01546  8.82002   30.81332 1.000 37.93139 ? 214 ASN A ND2 1 
ATOM   1641 N N   . GLY A 1 213 ? -6.92604  13.27350  27.68199 1.000 40.21698 ? 215 GLY A N   1 
ATOM   1642 C CA  . GLY A 1 213 ? -7.49555  14.48945  27.12743 1.000 43.49309 ? 215 GLY A CA  1 
ATOM   1643 C C   . GLY A 1 213 ? -7.36252  15.74651  27.96786 1.000 47.23865 ? 215 GLY A C   1 
ATOM   1644 O O   . GLY A 1 213 ? -7.68923  16.83644  27.47293 1.000 49.58830 ? 215 GLY A O   1 
ATOM   1645 N N   . ASP A 1 214 ? -6.91535  15.65366  29.22003 1.000 44.41322 ? 216 ASP A N   1 
ATOM   1646 C CA  . ASP A 1 214 ? -6.60964  16.86033  29.99197 1.000 45.87480 ? 216 ASP A CA  1 
ATOM   1647 C C   . ASP A 1 214 ? -5.27932  17.42716  29.49916 1.000 45.79391 ? 216 ASP A C   1 
ATOM   1648 O O   . ASP A 1 214 ? -4.22097  16.83158  29.72737 1.000 43.22773 ? 216 ASP A O   1 
ATOM   1649 C CB  . ASP A 1 214 ? -6.57503  16.56039  31.49098 1.000 47.43208 ? 216 ASP A CB  1 
ATOM   1650 C CG  . ASP A 1 214 ? -7.75498  17.18049  32.24136 1.000 55.98198 ? 216 ASP A CG  1 
ATOM   1651 O OD1 . ASP A 1 214 ? -8.02707  16.77402  33.39571 1.000 58.24659 ? 216 ASP A OD1 1 
ATOM   1652 O OD2 . ASP A 1 214 ? -8.40567  18.09053  31.67539 1.000 58.31809 ? 216 ASP A OD2 1 
ATOM   1653 N N   . ARG A 1 215 ? -5.32554  18.57406  28.81007 1.000 43.30692 ? 217 ARG A N   1 
ATOM   1654 C CA  . ARG A 1 215 ? -4.14628  19.11216  28.14222 1.000 40.53428 ? 217 ARG A CA  1 
ATOM   1655 C C   . ARG A 1 215 ? -3.90243  20.58230  28.43769 1.000 38.38436 ? 217 ARG A C   1 
ATOM   1656 O O   . ARG A 1 215 ? -2.94835  21.15388  27.89682 1.000 35.74640 ? 217 ARG A O   1 
ATOM   1657 C CB  . ARG A 1 215 ? -4.24756  18.93034  26.62275 1.000 43.75238 ? 217 ARG A CB  1 
ATOM   1658 C CG  . ARG A 1 215 ? -4.38309  17.48275  26.15435 1.000 46.09330 ? 217 ARG A CG  1 
ATOM   1659 C CD  . ARG A 1 215 ? -4.53853  17.40293  24.64063 1.000 44.53131 ? 217 ARG A CD  1 
ATOM   1660 N NE  . ARG A 1 215 ? -3.41292  18.04182  23.96296 1.000 48.73617 ? 217 ARG A NE  1 
ATOM   1661 C CZ  . ARG A 1 215 ? -2.42311  17.37595  23.37731 1.000 43.93434 ? 217 ARG A CZ  1 
ATOM   1662 N NH1 . ARG A 1 215 ? -1.43122  18.03975  22.79164 1.000 40.59078 ? 217 ARG A NH1 1 
ATOM   1663 N NH2 . ARG A 1 215 ? -2.42816  16.04595  23.37499 1.000 40.49516 ? 217 ARG A NH2 1 
ATOM   1664 N N   . TRP A 1 216 ? -4.72607  21.20803  29.27719 1.000 38.77847 ? 218 TRP A N   1 
ATOM   1665 C CA  . TRP A 1 216 ? -4.68347  22.65773  29.41867 1.000 38.19918 ? 218 TRP A CA  1 
ATOM   1666 C C   . TRP A 1 216 ? -3.34378  23.16045  29.93673 1.000 40.52169 ? 218 TRP A C   1 
ATOM   1667 O O   . TRP A 1 216 ? -2.98374  24.31912  29.68413 1.000 35.92378 ? 218 TRP A O   1 
ATOM   1668 C CB  . TRP A 1 216 ? -5.81769  23.12837  30.33667 1.000 41.84906 ? 218 TRP A CB  1 
ATOM   1669 C CG  . TRP A 1 216 ? -5.73267  22.64144  31.77457 1.000 40.51256 ? 218 TRP A CG  1 
ATOM   1670 C CD1 . TRP A 1 216 ? -6.39921  21.58761  32.31534 1.000 45.34324 ? 218 TRP A CD1 1 
ATOM   1671 C CD2 . TRP A 1 216 ? -4.95584  23.20770  32.83689 1.000 41.68871 ? 218 TRP A CD2 1 
ATOM   1672 N NE1 . TRP A 1 216 ? -6.08367  21.45025  33.64752 1.000 43.86239 ? 218 TRP A NE1 1 
ATOM   1673 C CE2 . TRP A 1 216 ? -5.19995  22.43354  33.99204 1.000 43.02060 ? 218 TRP A CE2 1 
ATOM   1674 C CE3 . TRP A 1 216 ? -4.07106  24.28785  32.92492 1.000 45.03569 ? 218 TRP A CE3 1 
ATOM   1675 C CZ2 . TRP A 1 216 ? -4.59830  22.70514  35.21486 1.000 45.07058 ? 218 TRP A CZ2 1 
ATOM   1676 C CZ3 . TRP A 1 216 ? -3.46581  24.55021  34.13960 1.000 40.76448 ? 218 TRP A CZ3 1 
ATOM   1677 C CH2 . TRP A 1 216 ? -3.73583  23.76417  35.26968 1.000 45.67453 ? 218 TRP A CH2 1 
ATOM   1678 N N   . PHE A 1 217 ? -2.59033  22.31922  30.63454 1.000 36.60782 ? 219 PHE A N   1 
ATOM   1679 C CA  . PHE A 1 217 ? -1.33336  22.73072  31.24121 1.000 34.17359 ? 219 PHE A CA  1 
ATOM   1680 C C   . PHE A 1 217 ? -0.13853  22.60192  30.30654 1.000 36.05658 ? 219 PHE A C   1 
ATOM   1681 O O   . PHE A 1 217 ? 0.97662   22.95030  30.70768 1.000 32.99443 ? 219 PHE A O   1 
ATOM   1682 C CB  . PHE A 1 217 ? -1.07276  21.89346  32.49936 1.000 35.89420 ? 219 PHE A CB  1 
ATOM   1683 C CG  . PHE A 1 217 ? -1.15585  20.41842  32.24412 1.000 37.06768 ? 219 PHE A CG  1 
ATOM   1684 C CD1 . PHE A 1 217 ? -0.03337  19.70975  31.84516 1.000 35.81369 ? 219 PHE A CD1 1 
ATOM   1685 C CD2 . PHE A 1 217 ? -2.36267  19.75252  32.35476 1.000 35.62092 ? 219 PHE A CD2 1 
ATOM   1686 C CE1 . PHE A 1 217 ? -0.11183  18.35894  31.59214 1.000 33.75628 ? 219 PHE A CE1 1 
ATOM   1687 C CE2 . PHE A 1 217 ? -2.45130  18.40140  32.10059 1.000 38.27354 ? 219 PHE A CE2 1 
ATOM   1688 C CZ  . PHE A 1 217 ? -1.33129  17.70390  31.70960 1.000 33.66991 ? 219 PHE A CZ  1 
ATOM   1689 N N   . LEU A 1 218 ? -0.31034  22.06691  29.10193 1.000 34.41685 ? 220 LEU A N   1 
ATOM   1690 C CA  . LEU A 1 218 ? 0.82114   22.01371  28.18829 1.000 36.26709 ? 220 LEU A CA  1 
ATOM   1691 C C   . LEU A 1 218 ? 1.14707   23.42339  27.72863 1.000 39.81489 ? 220 LEU A C   1 
ATOM   1692 O O   . LEU A 1 218 ? 0.24933   24.24577  27.51180 1.000 38.64402 ? 220 LEU A O   1 
ATOM   1693 C CB  . LEU A 1 218 ? 0.53134   21.11013  26.99092 1.000 35.19890 ? 220 LEU A CB  1 
ATOM   1694 C CG  . LEU A 1 218 ? 0.18809   19.66569  27.38371 1.000 34.66486 ? 220 LEU A CG  1 
ATOM   1695 C CD1 . LEU A 1 218 ? -0.29901  18.90411  26.17101 1.000 32.31409 ? 220 LEU A CD1 1 
ATOM   1696 C CD2 . LEU A 1 218 ? 1.36737   18.94682  28.04081 1.000 34.69398 ? 220 LEU A CD2 1 
ATOM   1697 N N   . ASN A 1 219 ? 2.43927   23.72412  27.64718 1.000 38.61339 ? 221 ASN A N   1 
ATOM   1698 C CA  . ASN A 1 219 ? 2.89871   25.02308  27.18464 1.000 40.86169 ? 221 ASN A CA  1 
ATOM   1699 C C   . ASN A 1 219 ? 3.93571   24.81056  26.09052 1.000 44.90596 ? 221 ASN A C   1 
ATOM   1700 O O   . ASN A 1 219 ? 4.39065   23.68719  25.83111 1.000 43.80842 ? 221 ASN A O   1 
ATOM   1701 C CB  . ASN A 1 219 ? 3.45684   25.88584  28.33958 1.000 41.29034 ? 221 ASN A CB  1 
ATOM   1702 C CG  . ASN A 1 219 ? 4.66434   25.26450  29.02701 1.000 42.30905 ? 221 ASN A CG  1 
ATOM   1703 O OD1 . ASN A 1 219 ? 5.53293   24.67799  28.38797 1.000 42.43945 ? 221 ASN A OD1 1 
ATOM   1704 N ND2 . ASN A 1 219 ? 4.73740   25.42853  30.34427 1.000 44.23962 ? 221 ASN A ND2 1 
ATOM   1705 N N   . ARG A 1 220 ? 4.29964   25.91165  25.43741 1.000 40.03819 ? 222 ARG A N   1 
ATOM   1706 C CA  . ARG A 1 220 ? 5.22666   25.84085  24.31319 1.000 46.37305 ? 222 ARG A CA  1 
ATOM   1707 C C   . ARG A 1 220 ? 6.65204   25.53666  24.75279 1.000 46.52138 ? 222 ARG A C   1 
ATOM   1708 O O   . ARG A 1 220 ? 7.45049   25.07951  23.93587 1.000 53.09728 ? 222 ARG A O   1 
ATOM   1709 C CB  . ARG A 1 220 ? 5.17470   27.16073  23.52547 1.000 50.11759 ? 222 ARG A CB  1 
ATOM   1710 C CG  . ARG A 1 220 ? 6.00108   28.21238  24.20158 1.000 50.27121 ? 222 ARG A CG  1 
ATOM   1711 C CD  . ARG A 1 220 ? 5.34526   29.56660  24.22810 1.000 55.81852 ? 222 ARG A CD  1 
ATOM   1712 N NE  . ARG A 1 220 ? 5.61359   30.40999  23.07227 1.000 58.58020 ? 222 ARG A NE  1 
ATOM   1713 C CZ  . ARG A 1 220 ? 6.75554   31.07393  22.89295 1.000 60.94538 ? 222 ARG A CZ  1 
ATOM   1714 N NH1 . ARG A 1 220 ? 7.75590   30.92179  23.75718 1.000 53.55328 ? 222 ARG A NH1 1 
ATOM   1715 N NH2 . ARG A 1 220 ? 6.91054   31.85451  21.83512 1.000 52.10389 ? 222 ARG A NH2 1 
ATOM   1716 N N   . PHE A 1 221 ? 6.97783   25.75083  26.01666 1.000 45.09703 ? 223 PHE A N   1 
ATOM   1717 C CA  . PHE A 1 221 ? 8.36804   25.80074  26.44829 1.000 47.05030 ? 223 PHE A CA  1 
ATOM   1718 C C   . PHE A 1 221 ? 8.99364   24.41724  26.59245 1.000 45.65504 ? 223 PHE A C   1 
ATOM   1719 O O   . PHE A 1 221 ? 8.31440   23.39118  26.67135 1.000 45.79193 ? 223 PHE A O   1 
ATOM   1720 C CB  . PHE A 1 221 ? 8.49084   26.52848  27.78587 1.000 44.27368 ? 223 PHE A CB  1 
ATOM   1721 C CG  . PHE A 1 221 ? 7.72307   27.80985  27.84619 1.000 47.59530 ? 223 PHE A CG  1 
ATOM   1722 C CD1 . PHE A 1 221 ? 7.99948   28.83645  26.96345 1.000 50.73995 ? 223 PHE A CD1 1 
ATOM   1723 C CD2 . PHE A 1 221 ? 6.71877   27.98807  28.77360 1.000 48.89977 ? 223 PHE A CD2 1 
ATOM   1724 C CE1 . PHE A 1 221 ? 7.30842   30.03078  27.03619 1.000 49.38265 ? 223 PHE A CE1 1 
ATOM   1725 C CE2 . PHE A 1 221 ? 6.01846   29.17915  28.83980 1.000 51.86690 ? 223 PHE A CE2 1 
ATOM   1726 C CZ  . PHE A 1 221 ? 6.32032   30.19841  27.97013 1.000 47.27831 ? 223 PHE A CZ  1 
ATOM   1727 N N   . THR A 1 222 ? 10.32029  24.41379  26.64552 1.000 39.12277 ? 224 THR A N   1 
ATOM   1728 C CA  . THR A 1 222 ? 11.09601  23.26597  27.06365 1.000 43.50209 ? 224 THR A CA  1 
ATOM   1729 C C   . THR A 1 222 ? 12.06466  23.73909  28.13427 1.000 43.33398 ? 224 THR A C   1 
ATOM   1730 O O   . THR A 1 222 ? 12.14935  24.92924  28.43895 1.000 41.64671 ? 224 THR A O   1 
ATOM   1731 C CB  . THR A 1 222 ? 11.82855  22.62139  25.88040 1.000 47.72463 ? 224 THR A CB  1 
ATOM   1732 O OG1 . THR A 1 222 ? 12.26588  21.30559  26.25038 1.000 45.16923 ? 224 THR A OG1 1 
ATOM   1733 C CG2 . THR A 1 222 ? 13.03593  23.46589  25.47527 1.000 45.68980 ? 224 THR A CG2 1 
ATOM   1734 N N   . THR A 1 223 ? 12.78685  22.80202  28.73174 1.000 44.56612 ? 225 THR A N   1 
ATOM   1735 C CA  . THR A 1 223 ? 13.74019  23.16056  29.76711 1.000 43.86704 ? 225 THR A CA  1 
ATOM   1736 C C   . THR A 1 223 ? 14.86365  22.13946  29.73890 1.000 44.51162 ? 225 THR A C   1 
ATOM   1737 O O   . THR A 1 223 ? 14.81470  21.15126  28.99790 1.000 46.43256 ? 225 THR A O   1 
ATOM   1738 C CB  . THR A 1 223 ? 13.06176  23.24652  31.14627 1.000 44.50154 ? 225 THR A CB  1 
ATOM   1739 O OG1 . THR A 1 223 ? 14.02812  23.60136  32.13996 1.000 47.53511 ? 225 THR A OG1 1 
ATOM   1740 C CG2 . THR A 1 223 ? 12.41544  21.90498  31.53161 1.000 44.03858 ? 225 THR A CG2 1 
ATOM   1741 N N   . THR A 1 224 ? 15.89563  22.40056  30.52849 1.000 45.45354 ? 226 THR A N   1 
ATOM   1742 C CA  . THR A 1 224 ? 16.93616  21.41158  30.75234 1.000 46.18092 ? 226 THR A CA  1 
ATOM   1743 C C   . THR A 1 224 ? 16.66670  20.71897  32.07545 1.000 43.18604 ? 226 THR A C   1 
ATOM   1744 O O   . THR A 1 224 ? 15.98796  21.26279  32.95269 1.000 41.97708 ? 226 THR A O   1 
ATOM   1745 C CB  . THR A 1 224 ? 18.32924  22.04912  30.75972 1.000 42.79222 ? 226 THR A CB  1 
ATOM   1746 O OG1 . THR A 1 224 ? 18.45827  22.91507  31.89932 1.000 45.22676 ? 226 THR A OG1 1 
ATOM   1747 C CG2 . THR A 1 224 ? 18.54361  22.84488  29.49168 1.000 44.77515 ? 226 THR A CG2 1 
ATOM   1748 N N   . LEU A 1 225 ? 17.18758  19.49324  32.19944 1.000 43.16771 ? 227 LEU A N   1 
ATOM   1749 C CA  . LEU A 1 225 ? 17.08676  18.78077  33.46673 1.000 41.56280 ? 227 LEU A CA  1 
ATOM   1750 C C   . LEU A 1 225 ? 17.65077  19.61688  34.60295 1.000 42.85367 ? 227 LEU A C   1 
ATOM   1751 O O   . LEU A 1 225 ? 17.05632  19.69158  35.68694 1.000 41.75201 ? 227 LEU A O   1 
ATOM   1752 C CB  . LEU A 1 225 ? 17.81410  17.43283  33.38216 1.000 44.68238 ? 227 LEU A CB  1 
ATOM   1753 C CG  . LEU A 1 225 ? 16.94192  16.17953  33.45345 1.000 43.05586 ? 227 LEU A CG  1 
ATOM   1754 C CD1 . LEU A 1 225 ? 17.76605  14.91311  33.70992 1.000 45.99280 ? 227 LEU A CD1 1 
ATOM   1755 C CD2 . LEU A 1 225 ? 15.87614  16.35301  34.51564 1.000 42.55174 ? 227 LEU A CD2 1 
ATOM   1756 N N   . ASN A 1 226 ? 18.79231  20.27365  34.36428 1.000 44.02158 ? 228 ASN A N   1 
ATOM   1757 C CA  . ASN A 1 226 ? 19.44416  21.04353  35.41996 1.000 40.61767 ? 228 ASN A CA  1 
ATOM   1758 C C   . ASN A 1 226 ? 18.58161  22.22097  35.86560 1.000 40.99576 ? 228 ASN A C   1 
ATOM   1759 O O   . ASN A 1 226 ? 18.40809  22.45671  37.06365 1.000 42.08342 ? 228 ASN A O   1 
ATOM   1760 C CB  . ASN A 1 226 ? 20.81842  21.51909  34.95017 1.000 40.19980 ? 228 ASN A CB  1 
ATOM   1761 C CG  . ASN A 1 226 ? 21.46604  22.48311  35.92983 1.000 44.92409 ? 228 ASN A CG  1 
ATOM   1762 O OD1 . ASN A 1 226 ? 21.54132  23.68907  35.66585 1.000 49.07561 ? 228 ASN A OD1 1 
ATOM   1763 N ND2 . ASN A 1 226 ? 21.91957  21.96515  37.07260 1.000 44.06754 ? 228 ASN A ND2 1 
ATOM   1764 N N   . ASP A 1 227 ? 18.03029  22.97856  34.92123 1.000 44.69219 ? 229 ASP A N   1 
ATOM   1765 C CA  . ASP A 1 227 ? 17.20658  24.11786  35.32084 1.000 44.94341 ? 229 ASP A CA  1 
ATOM   1766 C C   . ASP A 1 227 ? 15.88261  23.67467  35.93775 1.000 43.90782 ? 229 ASP A C   1 
ATOM   1767 O O   . ASP A 1 227 ? 15.36364  24.34409  36.83963 1.000 43.52329 ? 229 ASP A O   1 
ATOM   1768 C CB  . ASP A 1 227 ? 16.96523  25.04182  34.12763 1.000 47.46976 ? 229 ASP A CB  1 
ATOM   1769 C CG  . ASP A 1 227 ? 18.24006  25.71775  33.65282 1.000 51.98885 ? 229 ASP A CG  1 
ATOM   1770 O OD1 . ASP A 1 227 ? 18.23874  26.26028  32.52528 1.000 55.02213 ? 229 ASP A OD1 1 
ATOM   1771 O OD2 . ASP A 1 227 ? 19.24362  25.69569  34.40621 1.000 51.24557 ? 229 ASP A OD2 1 
ATOM   1772 N N   . PHE A 1 228 ? 15.31845  22.56344  35.46570 1.000 41.64815 ? 230 PHE A N   1 
ATOM   1773 C CA  . PHE A 1 228 ? 14.16037  21.99176  36.14372 1.000 41.43656 ? 230 PHE A CA  1 
ATOM   1774 C C   . PHE A 1 228 ? 14.48122  21.67814  37.60324 1.000 37.27944 ? 230 PHE A C   1 
ATOM   1775 O O   . PHE A 1 228 ? 13.75285  22.08847  38.51223 1.000 34.80921 ? 230 PHE A O   1 
ATOM   1776 C CB  . PHE A 1 228 ? 13.69584  20.72560  35.41732 1.000 42.49365 ? 230 PHE A CB  1 
ATOM   1777 C CG  . PHE A 1 228 ? 12.54711  20.03353  36.09685 1.000 39.72273 ? 230 PHE A CG  1 
ATOM   1778 C CD1 . PHE A 1 228 ? 11.23701  20.46886  35.88347 1.000 40.34346 ? 230 PHE A CD1 1 
ATOM   1779 C CD2 . PHE A 1 228 ? 12.77400  18.96332  36.95710 1.000 41.93967 ? 230 PHE A CD2 1 
ATOM   1780 C CE1 . PHE A 1 228 ? 10.17771  19.84563  36.51491 1.000 39.30417 ? 230 PHE A CE1 1 
ATOM   1781 C CE2 . PHE A 1 228 ? 11.71642  18.32570  37.59833 1.000 41.44441 ? 230 PHE A CE2 1 
ATOM   1782 C CZ  . PHE A 1 228 ? 10.41626  18.76750  37.37726 1.000 41.06196 ? 230 PHE A CZ  1 
ATOM   1783 N N   . ASN A 1 229 ? 15.56396  20.92788  37.84058 1.000 39.04955 ? 231 ASN A N   1 
ATOM   1784 C CA  . ASN A 1 229 ? 15.89197  20.47443  39.19201 1.000 42.33254 ? 231 ASN A CA  1 
ATOM   1785 C C   . ASN A 1 229 ? 16.17480  21.64501  40.13014 1.000 45.04416 ? 231 ASN A C   1 
ATOM   1786 O O   . ASN A 1 229 ? 15.88611  21.56946  41.33442 1.000 41.48091 ? 231 ASN A O   1 
ATOM   1787 C CB  . ASN A 1 229 ? 17.08793  19.52102  39.14114 1.000 39.40760 ? 231 ASN A CB  1 
ATOM   1788 C CG  . ASN A 1 229 ? 16.69843  18.11779  38.66423 1.000 44.41621 ? 231 ASN A CG  1 
ATOM   1789 O OD1 . ASN A 1 229 ? 15.67818  17.57287  39.08923 1.000 43.64430 ? 231 ASN A OD1 1 
ATOM   1790 N ND2 . ASN A 1 229 ? 17.49978  17.53965  37.77061 1.000 38.32956 ? 231 ASN A ND2 1 
ATOM   1791 N N   . LEU A 1 230 ? 16.72690  22.73639  39.59716 1.000 43.86784 ? 232 LEU A N   1 
ATOM   1792 C CA  . LEU A 1 230 ? 16.92517  23.93204  40.40639 1.000 45.57970 ? 232 LEU A CA  1 
ATOM   1793 C C   . LEU A 1 230 ? 15.59309  24.46171  40.93933 1.000 48.48185 ? 232 LEU A C   1 
ATOM   1794 O O   . LEU A 1 230 ? 15.47451  24.78103  42.13123 1.000 52.82057 ? 232 LEU A O   1 
ATOM   1795 C CB  . LEU A 1 230 ? 17.67286  24.98784  39.58714 1.000 42.16929 ? 232 LEU A CB  1 
ATOM   1796 C CG  . LEU A 1 230 ? 19.07646  24.57827  39.09985 1.000 49.88424 ? 232 LEU A CG  1 
ATOM   1797 C CD1 . LEU A 1 230 ? 19.83359  25.73562  38.45526 1.000 51.04073 ? 232 LEU A CD1 1 
ATOM   1798 C CD2 . LEU A 1 230 ? 19.93169  23.95593  40.21408 1.000 54.54964 ? 232 LEU A CD2 1 
ATOM   1799 N N   . VAL A 1 231 ? 14.56657  24.52241  40.08817 1.000 43.09384 ? 233 VAL A N   1 
ATOM   1800 C CA  . VAL A 1 231 ? 13.24878  24.94626  40.55991 1.000 43.44474 ? 233 VAL A CA  1 
ATOM   1801 C C   . VAL A 1 231 ? 12.63090  23.87963  41.45802 1.000 45.16542 ? 233 VAL A C   1 
ATOM   1802 O O   . VAL A 1 231 ? 12.15500  24.17700  42.56032 1.000 45.03492 ? 233 VAL A O   1 
ATOM   1803 C CB  . VAL A 1 231 ? 12.32531  25.28269  39.37377 1.000 46.92240 ? 233 VAL A CB  1 
ATOM   1804 C CG1 . VAL A 1 231 ? 10.87832  25.41214  39.84472 1.000 45.21046 ? 233 VAL A CG1 1 
ATOM   1805 C CG2 . VAL A 1 231 ? 12.77558  26.56283  38.68031 1.000 44.74287 ? 233 VAL A CG2 1 
ATOM   1806 N N   . ALA A 1 232 ? 12.63573  22.61710  41.00480 1.000 42.12875 ? 234 ALA A N   1 
ATOM   1807 C CA  . ALA A 1 232 ? 11.93381  21.56521  41.73239 1.000 43.48775 ? 234 ALA A CA  1 
ATOM   1808 C C   . ALA A 1 232 ? 12.35351  21.50750  43.19389 1.000 39.76815 ? 234 ALA A C   1 
ATOM   1809 O O   . ALA A 1 232 ? 11.51228  21.33026  44.08175 1.000 43.71913 ? 234 ALA A O   1 
ATOM   1810 C CB  . ALA A 1 232 ? 12.17214  20.21037  41.06401 1.000 48.36834 ? 234 ALA A CB  1 
ATOM   1811 N N   . MET A 1 233 ? 13.64744  21.67043  43.46430 1.000 41.10327 ? 235 MET A N   1 
ATOM   1812 C CA  . MET A 1 233 ? 14.14801  21.55013  44.82741 1.000 44.09982 ? 235 MET A CA  1 
ATOM   1813 C C   . MET A 1 233 ? 13.61204  22.63422  45.75756 1.000 46.33183 ? 235 MET A C   1 
ATOM   1814 O O   . MET A 1 233 ? 13.61988  22.44175  46.97968 1.000 47.60426 ? 235 MET A O   1 
ATOM   1815 C CB  . MET A 1 233 ? 15.67260  21.57905  44.82281 1.000 48.50516 ? 235 MET A CB  1 
ATOM   1816 C CG  . MET A 1 233 ? 16.31218  20.19813  44.97638 1.000 58.94534 ? 235 MET A CG  1 
ATOM   1817 S SD  . MET A 1 233 ? 16.08000  19.07444  43.57169 1.000 70.38391 ? 235 MET A SD  1 
ATOM   1818 C CE  . MET A 1 233 ? 17.66205  19.29265  42.76277 1.000 55.81461 ? 235 MET A CE  1 
ATOM   1819 N N   . LYS A 1 234 ? 13.15274  23.76727  45.21489 1.000 44.03817 ? 236 LYS A N   1 
ATOM   1820 C CA  . LYS A 1 234 ? 12.54599  24.79716  46.04493 1.000 40.35245 ? 236 LYS A CA  1 
ATOM   1821 C C   . LYS A 1 234 ? 11.15959  24.39911  46.52157 1.000 42.34598 ? 236 LYS A C   1 
ATOM   1822 O O   . LYS A 1 234 ? 10.69988  24.91306  47.54367 1.000 41.39621 ? 236 LYS A O   1 
ATOM   1823 C CB  . LYS A 1 234 ? 12.45312  26.10210  45.26255 1.000 44.77774 ? 236 LYS A CB  1 
ATOM   1824 C CG  . LYS A 1 234 ? 13.77337  26.58746  44.68600 1.000 51.61324 ? 236 LYS A CG  1 
ATOM   1825 C CD  . LYS A 1 234 ? 13.51764  27.60146  43.56963 1.000 56.55988 ? 236 LYS A CD  1 
ATOM   1826 C CE  . LYS A 1 234 ? 14.78388  28.35344  43.17115 1.000 58.04451 ? 236 LYS A CE  1 
ATOM   1827 N NZ  . LYS A 1 234 ? 14.45362  29.55277  42.33923 1.000 60.95790 ? 236 LYS A NZ  1 
ATOM   1828 N N   . TYR A 1 235 ? 10.48269  23.49530  45.80517 1.000 43.80842 ? 237 TYR A N   1 
ATOM   1829 C CA  . TYR A 1 235 ? 9.11869   23.08815  46.12401 1.000 42.15053 ? 237 TYR A CA  1 
ATOM   1830 C C   . TYR A 1 235 ? 9.06109   21.69510  46.72996 1.000 42.16109 ? 237 TYR A C   1 
ATOM   1831 O O   . TYR A 1 235 ? 8.00129   21.06358  46.71678 1.000 42.06756 ? 237 TYR A O   1 
ATOM   1832 C CB  . TYR A 1 235 ? 8.23487   23.15498  44.87798 1.000 39.32407 ? 237 TYR A CB  1 
ATOM   1833 C CG  . TYR A 1 235 ? 7.96455   24.56211  44.40171 1.000 43.34879 ? 237 TYR A CG  1 
ATOM   1834 C CD1 . TYR A 1 235 ? 8.87193   25.22000  43.57457 1.000 45.07975 ? 237 TYR A CD1 1 
ATOM   1835 C CD2 . TYR A 1 235 ? 6.80895   25.24158  44.78215 1.000 43.58637 ? 237 TYR A CD2 1 
ATOM   1836 C CE1 . TYR A 1 235 ? 8.63841   26.51310  43.13343 1.000 43.25702 ? 237 TYR A CE1 1 
ATOM   1837 C CE2 . TYR A 1 235 ? 6.56609   26.54181  44.34412 1.000 44.56823 ? 237 TYR A CE2 1 
ATOM   1838 C CZ  . TYR A 1 235 ? 7.48928   27.16902  43.52133 1.000 45.70933 ? 237 TYR A CZ  1 
ATOM   1839 O OH  . TYR A 1 235 ? 7.27155   28.45571  43.07010 1.000 53.58654 ? 237 TYR A OH  1 
ATOM   1840 N N   . ASN A 1 236 ? 10.18696  21.19830  47.24254 1.000 41.51229 ? 238 ASN A N   1 
ATOM   1841 C CA  . ASN A 1 236 ? 10.24340  19.90894  47.93399 1.000 43.49145 ? 238 ASN A CA  1 
ATOM   1842 C C   . ASN A 1 236 ? 9.96065   18.73663  46.98937 1.000 39.22108 ? 238 ASN A C   1 
ATOM   1843 O O   . ASN A 1 236 ? 9.26368   17.78828  47.35360 1.000 35.22993 ? 238 ASN A O   1 
ATOM   1844 C CB  . ASN A 1 236 ? 9.28815   19.87693  49.13020 1.000 40.02761 ? 238 ASN A CB  1 
ATOM   1845 C CG  . ASN A 1 236 ? 9.68624   18.84470  50.15630 1.000 46.61221 ? 238 ASN A CG  1 
ATOM   1846 O OD1 . ASN A 1 236 ? 10.86413  18.72419  50.49872 1.000 55.82633 ? 238 ASN A OD1 1 
ATOM   1847 N ND2 . ASN A 1 236 ? 8.70574   18.08916  50.66054 1.000 45.44582 ? 238 ASN A ND2 1 
ATOM   1848 N N   . TYR A 1 237 ? 10.52079  18.78694  45.78637 1.000 37.37877 ? 239 TYR A N   1 
ATOM   1849 C CA  . TYR A 1 237 ? 10.40028  17.70880  44.81345 1.000 34.49386 ? 239 TYR A CA  1 
ATOM   1850 C C   . TYR A 1 237 ? 11.71894  16.96440  44.72419 1.000 37.35913 ? 239 TYR A C   1 
ATOM   1851 O O   . TYR A 1 237 ? 12.78694  17.57918  44.77882 1.000 36.53981 ? 239 TYR A O   1 
ATOM   1852 C CB  . TYR A 1 237 ? 10.02386  18.24879  43.42671 1.000 34.70969 ? 239 TYR A CB  1 
ATOM   1853 C CG  . TYR A 1 237 ? 8.53799   18.35257  43.21424 1.000 35.53756 ? 239 TYR A CG  1 
ATOM   1854 C CD1 . TYR A 1 237 ? 7.73620   19.07556  44.09263 1.000 35.74587 ? 239 TYR A CD1 1 
ATOM   1855 C CD2 . TYR A 1 237 ? 7.93196   17.71662  42.14547 1.000 36.96931 ? 239 TYR A CD2 1 
ATOM   1856 C CE1 . TYR A 1 237 ? 6.37203   19.16253  43.90275 1.000 35.12244 ? 239 TYR A CE1 1 
ATOM   1857 C CE2 . TYR A 1 237 ? 6.57516   17.79722  41.94656 1.000 34.04573 ? 239 TYR A CE2 1 
ATOM   1858 C CZ  . TYR A 1 237 ? 5.79775   18.51464  42.82989 1.000 36.12959 ? 239 TYR A CZ  1 
ATOM   1859 O OH  . TYR A 1 237 ? 4.43831   18.57916  42.61256 1.000 39.88973 ? 239 TYR A OH  1 
ATOM   1860 N N   . GLU A 1 238 ? 11.64219  15.64210  44.56580 1.000 34.85311 ? 240 GLU A N   1 
ATOM   1861 C CA  . GLU A 1 238 ? 12.84994  14.86403  44.37788 1.000 36.70314 ? 240 GLU A CA  1 
ATOM   1862 C C   . GLU A 1 238 ? 13.53834  15.27323  43.07655 1.000 38.20182 ? 240 GLU A C   1 
ATOM   1863 O O   . GLU A 1 238 ? 12.87769  15.66406  42.11257 1.000 37.41004 ? 240 GLU A O   1 
ATOM   1864 C CB  . GLU A 1 238 ? 12.52888  13.36882  44.36652 1.000 40.96448 ? 240 GLU A CB  1 
ATOM   1865 C CG  . GLU A 1 238 ? 12.12228  12.85537  45.73359 1.000 43.57137 ? 240 GLU A CG  1 
ATOM   1866 C CD  . GLU A 1 238 ? 13.31979  12.75693  46.66786 1.000 47.53127 ? 240 GLU A CD  1 
ATOM   1867 O OE1 . GLU A 1 238 ? 13.25695  13.29674  47.79735 1.000 49.44960 ? 240 GLU A OE1 1 
ATOM   1868 O OE2 . GLU A 1 238 ? 14.33636  12.16441  46.25935 1.000 56.00530 ? 240 GLU A OE2 1 
ATOM   1869 N N   . PRO A 1 239 ? 14.86374  15.17893  43.01585 1.000 42.65158 ? 241 PRO A N   1 
ATOM   1870 C CA  . PRO A 1 239 ? 15.55629  15.48218  41.75836 1.000 42.65745 ? 241 PRO A CA  1 
ATOM   1871 C C   . PRO A 1 239 ? 15.13846  14.50979  40.66512 1.000 42.54280 ? 241 PRO A C   1 
ATOM   1872 O O   . PRO A 1 239 ? 14.88017  13.32745  40.91830 1.000 40.12738 ? 241 PRO A O   1 
ATOM   1873 C CB  . PRO A 1 239 ? 17.04460  15.30616  42.10471 1.000 43.87253 ? 241 PRO A CB  1 
ATOM   1874 C CG  . PRO A 1 239 ? 17.10512  14.90328  43.53922 1.000 47.04015 ? 241 PRO A CG  1 
ATOM   1875 C CD  . PRO A 1 239 ? 15.74187  14.50415  43.98594 1.000 43.05433 ? 241 PRO A CD  1 
ATOM   1876 N N   . LEU A 1 240 ? 15.08003  15.02112  39.43706 1.000 36.96801 ? 242 LEU A N   1 
ATOM   1877 C CA  . LEU A 1 240 ? 14.83242  14.20392  38.25824 1.000 40.26782 ? 242 LEU A CA  1 
ATOM   1878 C C   . LEU A 1 240 ? 16.16609  13.81282  37.62773 1.000 43.35792 ? 242 LEU A C   1 
ATOM   1879 O O   . LEU A 1 240 ? 17.01317  14.67655  37.37495 1.000 39.53003 ? 242 LEU A O   1 
ATOM   1880 C CB  . LEU A 1 240 ? 13.96618  14.95565  37.24752 1.000 39.10432 ? 242 LEU A CB  1 
ATOM   1881 C CG  . LEU A 1 240 ? 13.25389  14.04193  36.25749 1.000 42.55074 ? 242 LEU A CG  1 
ATOM   1882 C CD1 . LEU A 1 240 ? 12.19429  13.24768  37.00173 1.000 37.22426 ? 242 LEU A CD1 1 
ATOM   1883 C CD2 . LEU A 1 240 ? 12.64138  14.85097  35.13926 1.000 41.88685 ? 242 LEU A CD2 1 
ATOM   1884 N N   . THR A 1 241 ? 16.34740  12.52172  37.36521 1.000 31.98664 ? 243 THR A N   1 
ATOM   1885 C CA  . THR A 1 241 ? 17.60091  12.02038  36.81642 1.000 38.70563 ? 243 THR A CA  1 
ATOM   1886 C C   . THR A 1 241 ? 17.42134  11.62609  35.35216 1.000 40.31219 ? 243 THR A C   1 
ATOM   1887 O O   . THR A 1 241 ? 16.30416  11.51041  34.84317 1.000 37.16252 ? 243 THR A O   1 
ATOM   1888 C CB  . THR A 1 241 ? 18.12408  10.81854  37.62925 1.000 38.16546 ? 243 THR A CB  1 
ATOM   1889 O OG1 . THR A 1 241 ? 17.33443  9.66444   37.33939 1.000 37.69942 ? 243 THR A OG1 1 
ATOM   1890 C CG2 . THR A 1 241 ? 18.04468  11.09204  39.12016 1.000 40.85293 ? 243 THR A CG2 1 
ATOM   1891 N N   . GLN A 1 242 ? 18.55147  11.43439  34.66428 1.000 40.79029 ? 244 GLN A N   1 
ATOM   1892 C CA  . GLN A 1 242 ? 18.48714  10.93081  33.30000 1.000 42.73332 ? 244 GLN A CA  1 
ATOM   1893 C C   . GLN A 1 242 ? 17.80962  9.57163   33.25798 1.000 41.21787 ? 244 GLN A C   1 
ATOM   1894 O O   . GLN A 1 242 ? 17.05524  9.28796   32.32138 1.000 39.71480 ? 244 GLN A O   1 
ATOM   1895 C CB  . GLN A 1 242 ? 19.88791  10.85655  32.68502 1.000 47.91560 ? 244 GLN A CB  1 
ATOM   1896 C CG  . GLN A 1 242 ? 19.90853  10.40434  31.21871 1.000 45.07696 ? 244 GLN A CG  1 
ATOM   1897 C CD  . GLN A 1 242 ? 19.11320  11.32896  30.30391 1.000 48.29787 ? 244 GLN A CD  1 
ATOM   1898 O OE1 . GLN A 1 242 ? 19.06664  12.54269  30.51902 1.000 50.12426 ? 244 GLN A OE1 1 
ATOM   1899 N NE2 . GLN A 1 242 ? 18.48510  10.75651  29.26904 1.000 47.20496 ? 244 GLN A NE2 1 
ATOM   1900 N N   . ASP A 1 243 ? 18.03278  8.73613   34.27757 1.000 38.20610 ? 245 ASP A N   1 
ATOM   1901 C CA  . ASP A 1 243 ? 17.32722  7.45950   34.34787 1.000 43.49581 ? 245 ASP A CA  1 
ATOM   1902 C C   . ASP A 1 243 ? 15.81851  7.66385   34.38658 1.000 41.01505 ? 245 ASP A C   1 
ATOM   1903 O O   . ASP A 1 243 ? 15.06090  6.88188   33.79812 1.000 34.90609 ? 245 ASP A O   1 
ATOM   1904 C CB  . ASP A 1 243 ? 17.78263  6.66634   35.57440 1.000 46.63757 ? 245 ASP A CB  1 
ATOM   1905 C CG  . ASP A 1 243 ? 19.11752  5.97128   35.35807 1.000 49.67160 ? 245 ASP A CG  1 
ATOM   1906 O OD1 . ASP A 1 243 ? 19.50515  5.77003   34.18539 1.000 51.92265 ? 245 ASP A OD1 1 
ATOM   1907 O OD2 . ASP A 1 243 ? 19.77671  5.62302   36.36248 1.000 57.99126 ? 245 ASP A OD2 1 
ATOM   1908 N N   . HIS A 1 244 ? 15.36448  8.69548   35.10055 1.000 37.63875 ? 246 HIS A N   1 
ATOM   1909 C CA  . HIS A 1 244 ? 13.93534  8.99457   35.16392 1.000 34.95452 ? 246 HIS A CA  1 
ATOM   1910 C C   . HIS A 1 244 ? 13.41061  9.41656   33.80605 1.000 35.11771 ? 246 HIS A C   1 
ATOM   1911 O O   . HIS A 1 244 ? 12.29937  9.03487   33.41836 1.000 33.81417 ? 246 HIS A O   1 
ATOM   1912 C CB  . HIS A 1 244 ? 13.67149  10.09854  36.18645 1.000 37.44547 ? 246 HIS A CB  1 
ATOM   1913 C CG  . HIS A 1 244 ? 13.84549  9.66394   37.60702 1.000 39.66228 ? 246 HIS A CG  1 
ATOM   1914 N ND1 . HIS A 1 244 ? 14.29350  10.51547  38.59406 1.000 39.08889 ? 246 HIS A ND1 1 
ATOM   1915 C CD2 . HIS A 1 244 ? 13.61679  8.47351   38.21173 1.000 38.56967 ? 246 HIS A CD2 1 
ATOM   1916 C CE1 . HIS A 1 244 ? 14.32955  9.87082   39.74787 1.000 41.93583 ? 246 HIS A CE1 1 
ATOM   1917 N NE2 . HIS A 1 244 ? 13.92001  8.63047   39.54440 1.000 40.78323 ? 246 HIS A NE2 1 
ATOM   1918 N N   . VAL A 1 245 ? 14.19513  10.21929  33.07824 1.000 31.54195 ? 247 VAL A N   1 
ATOM   1919 C CA  . VAL A 1 245 ? 13.81427  10.60567  31.72811 1.000 34.36312 ? 247 VAL A CA  1 
ATOM   1920 C C   . VAL A 1 245 ? 13.67731  9.37628   30.84258 1.000 36.38661 ? 247 VAL A C   1 
ATOM   1921 O O   . VAL A 1 245 ? 12.71438  9.25231   30.07793 1.000 32.64458 ? 247 VAL A O   1 
ATOM   1922 C CB  . VAL A 1 245 ? 14.83766  11.60031  31.15025 1.000 38.52545 ? 247 VAL A CB  1 
ATOM   1923 C CG1 . VAL A 1 245 ? 14.55789  11.85212  29.67189 1.000 34.86092 ? 247 VAL A CG1 1 
ATOM   1924 C CG2 . VAL A 1 245 ? 14.82471  12.89060  31.94350 1.000 35.30408 ? 247 VAL A CG2 1 
ATOM   1925 N N   . ASP A 1 246 ? 14.64438  8.45132   30.92442 1.000 38.93245 ? 248 ASP A N   1 
ATOM   1926 C CA  . ASP A 1 246 ? 14.60010  7.24666   30.09560 1.000 37.23246 ? 248 ASP A CA  1 
ATOM   1927 C C   . ASP A 1 246 ? 13.39296  6.39400   30.44953 1.000 35.96554 ? 248 ASP A C   1 
ATOM   1928 O O   . ASP A 1 246 ? 12.73842  5.81408   29.57117 1.000 35.78519 ? 248 ASP A O   1 
ATOM   1929 C CB  . ASP A 1 246 ? 15.87660  6.42744   30.27947 1.000 41.64067 ? 248 ASP A CB  1 
ATOM   1930 C CG  . ASP A 1 246 ? 17.11605  7.12278   29.74483 1.000 44.79820 ? 248 ASP A CG  1 
ATOM   1931 O OD1 . ASP A 1 246 ? 16.99004  7.98817   28.85202 1.000 43.33299 ? 248 ASP A OD1 1 
ATOM   1932 O OD2 . ASP A 1 246 ? 18.22707  6.77023   30.21358 1.000 49.97124 ? 248 ASP A OD2 1 
ATOM   1933 N N   . ILE A 1 247 ? 13.10056  6.30121   31.74195 1.000 31.40047 ? 249 ILE A N   1 
ATOM   1934 C CA  . ILE A 1 247 ? 11.93172  5.59384   32.23186 1.000 33.01775 ? 249 ILE A CA  1 
ATOM   1935 C C   . ILE A 1 247 ? 10.64207  6.19041   31.67280 1.000 33.97771 ? 249 ILE A C   1 
ATOM   1936 O O   . ILE A 1 247 ? 9.69191   5.45291   31.38832 1.000 32.49842 ? 249 ILE A O   1 
ATOM   1937 C CB  . ILE A 1 247 ? 11.97992  5.58989   33.77252 1.000 39.59567 ? 249 ILE A CB  1 
ATOM   1938 C CG1 . ILE A 1 247 ? 12.94003  4.48304   34.24217 1.000 37.99958 ? 249 ILE A CG1 1 
ATOM   1939 C CG2 . ILE A 1 247 ? 10.59812  5.41857   34.37470 1.000 39.59884 ? 249 ILE A CG2 1 
ATOM   1940 C CD1 . ILE A 1 247 ? 13.40630  4.60268   35.69564 1.000 36.02933 ? 249 ILE A CD1 1 
ATOM   1941 N N   . LEU A 1 248 ? 10.59644  7.51232   31.44656 1.000 32.13658 ? 250 LEU A N   1 
ATOM   1942 C CA  . LEU A 1 248 ? 9.37600   8.12831   30.92694 1.000 30.61886 ? 250 LEU A CA  1 
ATOM   1943 C C   . LEU A 1 248 ? 9.24160   8.02288   29.40711 1.000 30.59496 ? 250 LEU A C   1 
ATOM   1944 O O   . LEU A 1 248 ? 8.20552   8.42090   28.86869 1.000 33.24621 ? 250 LEU A O   1 
ATOM   1945 C CB  . LEU A 1 248 ? 9.29863   9.60943   31.35335 1.000 32.71963 ? 250 LEU A CB  1 
ATOM   1946 C CG  . LEU A 1 248 ? 8.94180   9.89504   32.82442 1.000 30.56741 ? 250 LEU A CG  1 
ATOM   1947 C CD1 . LEU A 1 248 ? 9.28847   11.33095  33.25025 1.000 28.29671 ? 250 LEU A CD1 1 
ATOM   1948 C CD2 . LEU A 1 248 ? 7.47148   9.59833   33.13162 1.000 26.94630 ? 250 LEU A CD2 1 
ATOM   1949 N N   . GLY A 1 249 ? 10.23745  7.48170   28.71295 1.000 33.94923 ? 251 GLY A N   1 
ATOM   1950 C CA  . GLY A 1 249 ? 10.23090  7.37071   27.26682 1.000 33.58875 ? 251 GLY A CA  1 
ATOM   1951 C C   . GLY A 1 249 ? 8.95761   6.85385   26.60637 1.000 35.25196 ? 251 GLY A C   1 
ATOM   1952 O O   . GLY A 1 249 ? 8.45300   7.46501   25.65431 1.000 35.48599 ? 251 GLY A O   1 
ATOM   1953 N N   . PRO A 1 250 ? 8.42602   5.70509   27.05668 1.000 33.38979 ? 252 PRO A N   1 
ATOM   1954 C CA  . PRO A 1 250 ? 7.19189   5.19424   26.42281 1.000 34.09406 ? 252 PRO A CA  1 
ATOM   1955 C C   . PRO A 1 250 ? 6.03766   6.18206   26.47769 1.000 35.62762 ? 252 PRO A C   1 
ATOM   1956 O O   . PRO A 1 250 ? 5.30357   6.33106   25.48845 1.000 33.71247 ? 252 PRO A O   1 
ATOM   1957 C CB  . PRO A 1 250 ? 6.88790   3.91895   27.22135 1.000 31.75465 ? 252 PRO A CB  1 
ATOM   1958 C CG  . PRO A 1 250 ? 8.19445   3.48639   27.74187 1.000 33.93570 ? 252 PRO A CG  1 
ATOM   1959 C CD  . PRO A 1 250 ? 8.96540   4.74933   28.03667 1.000 34.52126 ? 252 PRO A CD  1 
ATOM   1960 N N   . LEU A 1 251 ? 5.86726   6.87683   27.60959 1.000 32.22845 ? 253 LEU A N   1 
ATOM   1961 C CA  . LEU A 1 251 ? 4.79130   7.85878   27.72233 1.000 33.75582 ? 253 LEU A CA  1 
ATOM   1962 C C   . LEU A 1 251 ? 5.03468   9.04274   26.79605 1.000 33.67364 ? 253 LEU A C   1 
ATOM   1963 O O   . LEU A 1 251 ? 4.10391   9.54650   26.15222 1.000 34.78811 ? 253 LEU A O   1 
ATOM   1964 C CB  . LEU A 1 251 ? 4.66001   8.31865   29.17659 1.000 31.45712 ? 253 LEU A CB  1 
ATOM   1965 C CG  . LEU A 1 251 ? 4.17798   7.17229   30.06641 1.000 34.80899 ? 253 LEU A CG  1 
ATOM   1966 C CD1 . LEU A 1 251 ? 4.01638   7.62977   31.51017 1.000 28.42565 ? 253 LEU A CD1 1 
ATOM   1967 C CD2 . LEU A 1 251 ? 2.87636   6.63948   29.51839 1.000 31.95485 ? 253 LEU A CD2 1 
ATOM   1968 N N   . SER A 1 252 ? 6.28370   9.48966   26.70979 1.000 34.56023 ? 254 SER A N   1 
ATOM   1969 C CA  . SER A 1 252 ? 6.63610   10.53051  25.75421 1.000 37.61062 ? 254 SER A CA  1 
ATOM   1970 C C   . SER A 1 252 ? 6.29358   10.10710  24.33007 1.000 41.41828 ? 254 SER A C   1 
ATOM   1971 O O   . SER A 1 252 ? 5.72523   10.88968  23.55581 1.000 41.93120 ? 254 SER A O   1 
ATOM   1972 C CB  . SER A 1 252 ? 8.12450   10.84311  25.87662 1.000 34.15890 ? 254 SER A CB  1 
ATOM   1973 O OG  . SER A 1 252 ? 8.48857   11.85688  24.97397 1.000 43.97606 ? 254 SER A OG  1 
ATOM   1974 N N   . ALA A 1 253 ? 6.61645   8.86104   23.97268 1.000 39.15214 ? 255 ALA A N   1 
ATOM   1975 C CA  . ALA A 1 253 ? 6.40347   8.40313   22.60493 1.000 41.15231 ? 255 ALA A CA  1 
ATOM   1976 C C   . ALA A 1 253 ? 4.91949   8.26923   22.29033 1.000 42.20621 ? 255 ALA A C   1 
ATOM   1977 O O   . ALA A 1 253 ? 4.48810   8.57087   21.17442 1.000 42.53316 ? 255 ALA A O   1 
ATOM   1978 C CB  . ALA A 1 253 ? 7.13173   7.07721   22.37957 1.000 42.10646 ? 255 ALA A CB  1 
ATOM   1979 N N   . GLN A 1 254 ? 4.11971   7.83221   23.26115 1.000 41.99677 ? 256 GLN A N   1 
ATOM   1980 C CA  . GLN A 1 254 ? 2.69532   7.65080   23.00680 1.000 38.87945 ? 256 GLN A CA  1 
ATOM   1981 C C   . GLN A 1 254 ? 1.99648   8.98770   22.77196 1.000 43.91298 ? 256 GLN A C   1 
ATOM   1982 O O   . GLN A 1 254 ? 1.07421   9.07711   21.95452 1.000 42.85439 ? 256 GLN A O   1 
ATOM   1983 C CB  . GLN A 1 254 ? 2.06122   6.90174   24.17468 1.000 42.26061 ? 256 GLN A CB  1 
ATOM   1984 C CG  . GLN A 1 254 ? 0.54650   6.98612   24.22807 1.000 47.28121 ? 256 GLN A CG  1 
ATOM   1985 C CD  . GLN A 1 254 ? -0.04702  5.94151   25.15953 1.000 58.32983 ? 256 GLN A CD  1 
ATOM   1986 O OE1 . GLN A 1 254 ? 0.60694   5.50568   26.11438 1.000 54.35405 ? 256 GLN A OE1 1 
ATOM   1987 N NE2 . GLN A 1 254 ? -1.29788  5.55014   24.90328 1.000 57.02790 ? 256 GLN A NE2 1 
ATOM   1988 N N   . THR A 1 255 ? 2.42447   10.03812  23.47607 1.000 39.03197 ? 257 THR A N   1 
ATOM   1989 C CA  . THR A 1 255 ? 1.80758   11.35808  23.39484 1.000 38.72116 ? 257 THR A CA  1 
ATOM   1990 C C   . THR A 1 255 ? 2.51381   12.31031  22.43929 1.000 39.56977 ? 257 THR A C   1 
ATOM   1991 O O   . THR A 1 255 ? 1.95125   13.35785  22.11444 1.000 37.58386 ? 257 THR A O   1 
ATOM   1992 C CB  . THR A 1 255 ? 1.78519   12.02581  24.77758 1.000 38.37530 ? 257 THR A CB  1 
ATOM   1993 O OG1 . THR A 1 255 ? 3.12987   12.12434  25.26699 1.000 37.05796 ? 257 THR A OG1 1 
ATOM   1994 C CG2 . THR A 1 255 ? 0.94841   11.23417  25.77092 1.000 33.92920 ? 257 THR A CG2 1 
ATOM   1995 N N   . GLY A 1 256 ? 3.73428   11.99963  22.01198 1.000 38.05929 ? 258 GLY A N   1 
ATOM   1996 C CA  . GLY A 1 256 ? 4.49187   12.94873  21.22614 1.000 38.90899 ? 258 GLY A CA  1 
ATOM   1997 C C   . GLY A 1 256 ? 4.98530   14.16465  21.98264 1.000 44.54036 ? 258 GLY A C   1 
ATOM   1998 O O   . GLY A 1 256 ? 5.39507   15.14444  21.35191 1.000 44.22563 ? 258 GLY A O   1 
ATOM   1999 N N   . ILE A 1 257 ? 4.96652   14.14711  23.31365 1.000 40.61781 ? 259 ILE A N   1 
ATOM   2000 C CA  . ILE A 1 257 ? 5.47928   15.25656  24.11549 1.000 36.86307 ? 259 ILE A CA  1 
ATOM   2001 C C   . ILE A 1 257 ? 6.79225   14.80789  24.73634 1.000 38.11780 ? 259 ILE A C   1 
ATOM   2002 O O   . ILE A 1 257 ? 6.82207   13.82217  25.48473 1.000 35.38222 ? 259 ILE A O   1 
ATOM   2003 C CB  . ILE A 1 257 ? 4.48183   15.68145  25.19615 1.000 33.39629 ? 259 ILE A CB  1 
ATOM   2004 C CG1 . ILE A 1 257 ? 3.16138   16.09076  24.56423 1.000 37.38366 ? 259 ILE A CG1 1 
ATOM   2005 C CG2 . ILE A 1 257 ? 5.07202   16.79076  26.07676 1.000 33.82177 ? 259 ILE A CG2 1 
ATOM   2006 C CD1 . ILE A 1 257 ? 2.01013   16.06397  25.53707 1.000 37.98182 ? 259 ILE A CD1 1 
ATOM   2007 N N   . ALA A 1 258 ? 7.87337   15.51876  24.41531 1.000 35.66527 ? 260 ALA A N   1 
ATOM   2008 C CA  . ALA A 1 258 ? 9.18008   15.20853  24.97922 1.000 37.52156 ? 260 ALA A CA  1 
ATOM   2009 C C   . ALA A 1 258 ? 9.16350   15.37281  26.49045 1.000 36.44470 ? 260 ALA A C   1 
ATOM   2010 O O   . ALA A 1 258 ? 8.38631   16.15289  27.04893 1.000 34.48537 ? 260 ALA A O   1 
ATOM   2011 C CB  . ALA A 1 258 ? 10.26067  16.11333  24.37923 1.000 42.51108 ? 260 ALA A CB  1 
ATOM   2012 N N   . VAL A 1 259 ? 10.04712  14.62810  27.15188 1.000 32.38084 ? 261 VAL A N   1 
ATOM   2013 C CA  . VAL A 1 259 ? 10.08167  14.63809  28.60730 1.000 32.25331 ? 261 VAL A CA  1 
ATOM   2014 C C   . VAL A 1 259 ? 10.38217  16.04272  29.12096 1.000 33.65377 ? 261 VAL A C   1 
ATOM   2015 O O   . VAL A 1 259 ? 9.71944   16.54225  30.03786 1.000 32.29672 ? 261 VAL A O   1 
ATOM   2016 C CB  . VAL A 1 259 ? 11.10310  13.60676  29.11868 1.000 31.24366 ? 261 VAL A CB  1 
ATOM   2017 C CG1 . VAL A 1 259 ? 11.37303  13.80340  30.57450 1.000 27.71473 ? 261 VAL A CG1 1 
ATOM   2018 C CG2 . VAL A 1 259 ? 10.59983  12.18654  28.84254 1.000 34.66296 ? 261 VAL A CG2 1 
ATOM   2019 N N   . LEU A 1 260 ? 11.38447  16.70528  28.53971 1.000 37.62968 ? 262 LEU A N   1 
ATOM   2020 C CA  . LEU A 1 260 ? 11.73921  18.04346  29.01564 1.000 38.32792 ? 262 LEU A CA  1 
ATOM   2021 C C   . LEU A 1 260 ? 10.67705  19.08687  28.66528 1.000 36.60093 ? 262 LEU A C   1 
ATOM   2022 O O   . LEU A 1 260 ? 10.64344  20.15433  29.28281 1.000 34.79649 ? 262 LEU A O   1 
ATOM   2023 C CB  . LEU A 1 260 ? 13.10665  18.45451  28.46066 1.000 38.90436 ? 262 LEU A CB  1 
ATOM   2024 C CG  . LEU A 1 260 ? 14.26953  17.58038  28.96271 1.000 39.36879 ? 262 LEU A CG  1 
ATOM   2025 C CD1 . LEU A 1 260 ? 15.60986  18.08449  28.45258 1.000 38.78633 ? 262 LEU A CD1 1 
ATOM   2026 C CD2 . LEU A 1 260 ? 14.27273  17.52753  30.47629 1.000 39.95463 ? 262 LEU A CD2 1 
ATOM   2027 N N   . ASP A 1 261 ? 9.80685   18.79604  27.70048 1.000 37.45999 ? 263 ASP A N   1 
ATOM   2028 C CA  . ASP A 1 261 ? 8.65121   19.65332  27.44960 1.000 40.11403 ? 263 ASP A CA  1 
ATOM   2029 C C   . ASP A 1 261 ? 7.62568   19.51888  28.57411 1.000 37.26409 ? 263 ASP A C   1 
ATOM   2030 O O   . ASP A 1 261 ? 7.09501   20.51643  29.07420 1.000 36.71546 ? 263 ASP A O   1 
ATOM   2031 C CB  . ASP A 1 261 ? 8.03798   19.28217  26.09610 1.000 37.12666 ? 263 ASP A CB  1 
ATOM   2032 C CG  . ASP A 1 261 ? 7.02368   20.29426  25.59852 1.000 48.68904 ? 263 ASP A CG  1 
ATOM   2033 O OD1 . ASP A 1 261 ? 6.61421   21.20644  26.36600 1.000 54.16010 ? 263 ASP A OD1 1 
ATOM   2034 O OD2 . ASP A 1 261 ? 6.62820   20.16367  24.41544 1.000 54.37673 ? 263 ASP A OD2 1 
ATOM   2035 N N   . MET A 1 262 ? 7.32543   18.28453  28.97947 1.000 34.10457 ? 264 MET A N   1 
ATOM   2036 C CA  . MET A 1 262 ? 6.44428   18.08865  30.12821 1.000 33.86739 ? 264 MET A CA  1 
ATOM   2037 C C   . MET A 1 262 ? 7.05890   18.65516  31.39995 1.000 31.22000 ? 264 MET A C   1 
ATOM   2038 O O   . MET A 1 262 ? 6.34010   19.14702  32.27480 1.000 32.33723 ? 264 MET A O   1 
ATOM   2039 C CB  . MET A 1 262 ? 6.14466   16.59459  30.30803 1.000 33.73173 ? 264 MET A CB  1 
ATOM   2040 C CG  . MET A 1 262 ? 5.03343   16.28679  31.29577 1.000 34.00840 ? 264 MET A CG  1 
ATOM   2041 S SD  . MET A 1 262 ? 3.44275   16.85827  30.66180 1.000 34.76349 ? 264 MET A SD  1 
ATOM   2042 C CE  . MET A 1 262 ? 2.98937   15.52401  29.56065 1.000 29.52305 ? 264 MET A CE  1 
ATOM   2043 N N   . CYS A 1 263 ? 8.38027   18.54864  31.53747 1.000 33.52672 ? 265 CYS A N   1 
ATOM   2044 C CA  . CYS A 1 263 ? 9.07023   19.16881  32.65891 1.000 33.40519 ? 265 CYS A CA  1 
ATOM   2045 C C   . CYS A 1 263 ? 8.84369   20.67476  32.67594 1.000 33.62596 ? 265 CYS A C   1 
ATOM   2046 O O   . CYS A 1 263 ? 8.68668   21.27136  33.74751 1.000 31.39148 ? 265 CYS A O   1 
ATOM   2047 C CB  . CYS A 1 263 ? 10.56148  18.84564  32.59037 1.000 33.15892 ? 265 CYS A CB  1 
ATOM   2048 S SG  . CYS A 1 263 ? 10.94797  17.14180  33.09250 1.000 34.86894 ? 265 CYS A SG  1 
ATOM   2049 N N   . ALA A 1 264 ? 8.82162   21.30909  31.50192 1.000 33.79750 ? 266 ALA A N   1 
ATOM   2050 C CA  . ALA A 1 264 ? 8.54649   22.74729  31.47560 1.000 37.65448 ? 266 ALA A CA  1 
ATOM   2051 C C   . ALA A 1 264 ? 7.12903   23.03144  31.94637 1.000 37.67507 ? 266 ALA A C   1 
ATOM   2052 O O   . ALA A 1 264 ? 6.88595   24.02162  32.64570 1.000 34.23784 ? 266 ALA A O   1 
ATOM   2053 C CB  . ALA A 1 264 ? 8.76612   23.30964  30.07025 1.000 38.34198 ? 266 ALA A CB  1 
ATOM   2054 N N   . SER A 1 265 ? 6.18048   22.15881  31.57806 1.000 39.34417 ? 267 SER A N   1 
ATOM   2055 C CA  . SER A 1 265 ? 4.80164   22.30714  32.03721 1.000 35.19820 ? 267 SER A CA  1 
ATOM   2056 C C   . SER A 1 265 ? 4.70229   22.14135  33.54863 1.000 36.70953 ? 267 SER A C   1 
ATOM   2057 O O   . SER A 1 265 ? 3.97573   22.88809  34.22105 1.000 36.30788 ? 267 SER A O   1 
ATOM   2058 C CB  . SER A 1 265 ? 3.89708   21.28632  31.33286 1.000 38.07116 ? 267 SER A CB  1 
ATOM   2059 O OG  . SER A 1 265 ? 3.80319   21.53130  29.94711 1.000 39.09574 ? 267 SER A OG  1 
ATOM   2060 N N   . LEU A 1 266 ? 5.40483   21.15185  34.10376 1.000 31.15092 ? 268 LEU A N   1 
ATOM   2061 C CA  . LEU A 1 266 ? 5.35873   20.97872  35.54998 1.000 32.91685 ? 268 LEU A CA  1 
ATOM   2062 C C   . LEU A 1 266 ? 6.02068   22.15883  36.25500 1.000 36.50959 ? 268 LEU A C   1 
ATOM   2063 O O   . LEU A 1 266 ? 5.54699   22.60963  37.30118 1.000 39.31033 ? 268 LEU A O   1 
ATOM   2064 C CB  . LEU A 1 266 ? 6.01272   19.65568  35.95713 1.000 28.13868 ? 268 LEU A CB  1 
ATOM   2065 C CG  . LEU A 1 266 ? 6.21977   19.41011  37.46570 1.000 28.52835 ? 268 LEU A CG  1 
ATOM   2066 C CD1 . LEU A 1 266 ? 4.92184   19.50877  38.23588 1.000 28.41988 ? 268 LEU A CD1 1 
ATOM   2067 C CD2 . LEU A 1 266 ? 6.87001   18.05195  37.71085 1.000 32.99647 ? 268 LEU A CD2 1 
ATOM   2068 N N   . LYS A 1 267 ? 7.08741   22.70009  35.67050 1.000 35.66852 ? 269 LYS A N   1 
ATOM   2069 C CA  . LYS A 1 267 ? 7.73948   23.86619  36.26059 1.000 40.34396 ? 269 LYS A CA  1 
ATOM   2070 C C   . LYS A 1 267 ? 6.79082   25.06166  36.38567 1.000 41.88324 ? 269 LYS A C   1 
ATOM   2071 O O   . LYS A 1 267 ? 6.77149   25.73418  37.42428 1.000 41.23452 ? 269 LYS A O   1 
ATOM   2072 C CB  . LYS A 1 267 ? 8.99001   24.21412  35.45023 1.000 43.34646 ? 269 LYS A CB  1 
ATOM   2073 C CG  . LYS A 1 267 ? 9.45186   25.65787  35.59112 1.000 48.40433 ? 269 LYS A CG  1 
ATOM   2074 C CD  . LYS A 1 267 ? 10.57771  25.95973  34.61199 1.000 48.96044 ? 269 LYS A CD  1 
ATOM   2075 C CE  . LYS A 1 267 ? 11.74667  25.00707  34.81453 1.000 48.72045 ? 269 LYS A CE  1 
ATOM   2076 N NZ  . LYS A 1 267 ? 13.00467  25.51580  34.19563 1.000 50.42312 ? 269 LYS A NZ  1 
ATOM   2077 N N   . GLU A 1 268 ? 5.97722   25.33140  35.36922 1.000 36.79418 ? 270 GLU A N   1 
ATOM   2078 C CA  . GLU A 1 268 ? 5.08026   26.47182  35.47905 1.000 43.69981 ? 270 GLU A CA  1 
ATOM   2079 C C   . GLU A 1 268 ? 3.88920   26.16286  36.39166 1.000 46.94141 ? 270 GLU A C   1 
ATOM   2080 O O   . GLU A 1 268 ? 3.31417   27.07367  37.00218 1.000 48.74148 ? 270 GLU A O   1 
ATOM   2081 C CB  . GLU A 1 268 ? 4.59603   26.89170  34.09744 1.000 40.45379 ? 270 GLU A CB  1 
ATOM   2082 C CG  . GLU A 1 268 ? 3.71317   25.86203  33.49712 1.000 51.68221 ? 270 GLU A CG  1 
ATOM   2083 C CD  . GLU A 1 268 ? 2.18742   26.23126  33.46587 1.000 59.14306 ? 270 GLU A CD  1 
ATOM   2084 O OE1 . GLU A 1 268 ? 1.35736   25.45664  32.95051 1.000 56.77942 ? 270 GLU A OE1 1 
ATOM   2085 O OE2 . GLU A 1 268 ? 1.80425   27.34397  33.93118 1.000 58.22022 ? 270 GLU A OE2 1 
ATOM   2086 N N   . LEU A 1 269 ? 3.48060   24.89256  36.48862 1.000 41.97816 ? 271 LEU A N   1 
ATOM   2087 C CA  . LEU A 1 269 ? 2.39717   24.55602  37.41410 1.000 41.47255 ? 271 LEU A CA  1 
ATOM   2088 C C   . LEU A 1 269 ? 2.82848   24.81179  38.84670 1.000 43.25804 ? 271 LEU A C   1 
ATOM   2089 O O   . LEU A 1 269 ? 2.03559   25.28402  39.66886 1.000 45.62153 ? 271 LEU A O   1 
ATOM   2090 C CB  . LEU A 1 269 ? 1.96453   23.09777  37.24205 1.000 40.19786 ? 271 LEU A CB  1 
ATOM   2091 C CG  . LEU A 1 269 ? 1.02537   22.72264  36.09509 1.000 42.52677 ? 271 LEU A CG  1 
ATOM   2092 C CD1 . LEU A 1 269 ? 0.73228   21.20869  36.11714 1.000 41.45872 ? 271 LEU A CD1 1 
ATOM   2093 C CD2 . LEU A 1 269 ? -0.25837  23.52201  36.18141 1.000 46.69307 ? 271 LEU A CD2 1 
ATOM   2094 N N   . LEU A 1 270 ? 4.09957   24.53180  39.14940 1.000 38.24205 ? 272 LEU A N   1 
ATOM   2095 C CA  . LEU A 1 270 ? 4.62523   24.74350  40.48960 1.000 42.55753 ? 272 LEU A CA  1 
ATOM   2096 C C   . LEU A 1 270 ? 4.70684   26.22648  40.81345 1.000 46.23378 ? 272 LEU A C   1 
ATOM   2097 O O   . LEU A 1 270 ? 4.35277   26.65054  41.92059 1.000 44.03480 ? 272 LEU A O   1 
ATOM   2098 C CB  . LEU A 1 270 ? 6.00324   24.09237  40.61212 1.000 41.43818 ? 272 LEU A CB  1 
ATOM   2099 C CG  . LEU A 1 270 ? 6.07851   22.56188  40.51182 1.000 39.94047 ? 272 LEU A CG  1 
ATOM   2100 C CD1 . LEU A 1 270 ? 7.50701   22.08323  40.68699 1.000 35.43653 ? 272 LEU A CD1 1 
ATOM   2101 C CD2 . LEU A 1 270 ? 5.17230   21.91855  41.54514 1.000 36.49940 ? 272 LEU A CD2 1 
ATOM   2102 N N   . GLN A 1 271 ? 5.14808   27.03251  39.85208 1.000 47.39464 ? 273 GLN A N   1 
ATOM   2103 C CA  . GLN A 1 271 ? 5.31765   28.45737  40.08743 1.000 47.36367 ? 273 GLN A CA  1 
ATOM   2104 C C   . GLN A 1 271 ? 4.01675   29.24827  40.01924 1.000 52.53266 ? 273 GLN A C   1 
ATOM   2105 O O   . GLN A 1 271 ? 3.99121   30.38996  40.49115 1.000 61.23742 ? 273 GLN A O   1 
ATOM   2106 C CB  . GLN A 1 271 ? 6.32084   29.01689  39.09071 1.000 46.70033 ? 273 GLN A CB  1 
ATOM   2107 C CG  . GLN A 1 271 ? 7.70503   28.44365  39.28241 1.000 46.98493 ? 273 GLN A CG  1 
ATOM   2108 C CD  . GLN A 1 271 ? 8.59988   28.72270  38.10155 1.000 51.39778 ? 273 GLN A CD  1 
ATOM   2109 O OE1 . GLN A 1 271 ? 8.13720   28.78554  36.96169 1.000 53.81412 ? 273 GLN A OE1 1 
ATOM   2110 N NE2 . GLN A 1 271 ? 9.88900   28.90330  38.36432 1.000 49.54727 ? 273 GLN A NE2 1 
ATOM   2111 N N   . ASN A 1 272 ? 2.93890   28.67946  39.45838 1.000 52.07868 ? 274 ASN A N   1 
ATOM   2112 C CA  . ASN A 1 272 ? 1.67820   29.39715  39.29700 1.000 50.20540 ? 274 ASN A CA  1 
ATOM   2113 C C   . ASN A 1 272 ? 0.46529   28.75556  39.96058 1.000 55.70476 ? 274 ASN A C   1 
ATOM   2114 O O   . ASN A 1 272 ? -0.58297  29.40934  40.02509 1.000 54.86444 ? 274 ASN A O   1 
ATOM   2115 C CB  . ASN A 1 272 ? 1.32593   29.56990  37.81063 1.000 54.79459 ? 274 ASN A CB  1 
ATOM   2116 C CG  . ASN A 1 272 ? 2.42872   30.21010  37.00519 1.000 59.94824 ? 274 ASN A CG  1 
ATOM   2117 O OD1 . ASN A 1 272 ? 3.42766   30.68342  37.54943 1.000 64.16098 ? 274 ASN A OD1 1 
ATOM   2118 N ND2 . ASN A 1 272 ? 2.24329   30.24444  35.68396 1.000 59.22186 ? 274 ASN A ND2 1 
ATOM   2119 N N   . GLY A 1 273 ? 0.54681   27.50514  40.41831 1.000 52.34985 ? 275 GLY A N   1 
ATOM   2120 C CA  . GLY A 1 273 ? -0.64934  26.78620  40.81632 1.000 47.88410 ? 275 GLY A CA  1 
ATOM   2121 C C   . GLY A 1 273 ? -1.54918  26.53687  39.61924 1.000 51.47918 ? 275 GLY A C   1 
ATOM   2122 O O   . GLY A 1 273 ? -1.19534  26.79413  38.47255 1.000 55.87069 ? 275 GLY A O   1 
ATOM   2123 N N   . MET A 1 274 ? -2.75536  26.04575  39.90691 1.000 53.09520 ? 276 MET A N   1 
ATOM   2124 C CA  . MET A 1 274 ? -3.66165  25.58700  38.86508 1.000 52.00559 ? 276 MET A CA  1 
ATOM   2125 C C   . MET A 1 274 ? -4.76006  26.58378  38.51209 1.000 58.12032 ? 276 MET A C   1 
ATOM   2126 O O   . MET A 1 274 ? -5.51799  26.32226  37.57007 1.000 56.93751 ? 276 MET A O   1 
ATOM   2127 C CB  . MET A 1 274 ? -4.31003  24.26028  39.27711 1.000 53.07486 ? 276 MET A CB  1 
ATOM   2128 C CG  . MET A 1 274 ? -3.33750  23.09693  39.45540 1.000 54.74224 ? 276 MET A CG  1 
ATOM   2129 S SD  . MET A 1 274 ? -4.19221  21.52327  39.30167 1.000 58.93428 ? 276 MET A SD  1 
ATOM   2130 C CE  . MET A 1 274 ? -3.09747  20.44713  40.20132 1.000 45.91574 ? 276 MET A CE  1 
ATOM   2131 N N   . ASN A 1 275 ? -4.87642  27.70079  39.24044 1.000 56.39178 ? 277 ASN A N   1 
ATOM   2132 C CA  . ASN A 1 275 ? -5.93042  28.70077  39.00809 1.000 60.70905 ? 277 ASN A CA  1 
ATOM   2133 C C   . ASN A 1 275 ? -7.33760  28.10491  39.10157 1.000 60.77389 ? 277 ASN A C   1 
ATOM   2134 O O   . ASN A 1 275 ? -8.23815  28.47608  38.34207 1.000 61.01650 ? 277 ASN A O   1 
ATOM   2135 C CB  . ASN A 1 275 ? -5.74738  29.39809  37.65945 1.000 61.40425 ? 277 ASN A CB  1 
ATOM   2136 C CG  . ASN A 1 275 ? -5.08197  30.74157  37.79491 1.000 69.54538 ? 277 ASN A CG  1 
ATOM   2137 O OD1 . ASN A 1 275 ? -3.86751  30.82466  37.97504 1.000 75.57278 ? 277 ASN A OD1 1 
ATOM   2138 N ND2 . ASN A 1 275 ? -5.87441  31.80788  37.72987 1.000 65.70326 ? 277 ASN A ND2 1 
ATOM   2139 N N   . GLY A 1 276 ? -7.53667  27.17745  40.03679 1.000 58.12676 ? 278 GLY A N   1 
ATOM   2140 C CA  . GLY A 1 276 ? -8.83321  26.55995  40.20271 1.000 55.63096 ? 278 GLY A CA  1 
ATOM   2141 C C   . GLY A 1 276 ? -9.18738  25.52845  39.16128 1.000 58.71284 ? 278 GLY A C   1 
ATOM   2142 O O   . GLY A 1 276 ? -10.25635 24.91083  39.26458 1.000 58.27244 ? 278 GLY A O   1 
ATOM   2143 N N   . ARG A 1 277 ? -8.34035  25.33379  38.15382 1.000 57.28610 ? 279 ARG A N   1 
ATOM   2144 C CA  . ARG A 1 277 ? -8.50601  24.21770  37.24288 1.000 51.25238 ? 279 ARG A CA  1 
ATOM   2145 C C   . ARG A 1 277 ? -8.09620  22.92255  37.93590 1.000 53.77181 ? 279 ARG A C   1 
ATOM   2146 O O   . ARG A 1 277 ? -7.40905  22.92115  38.95922 1.000 52.30889 ? 279 ARG A O   1 
ATOM   2147 C CB  . ARG A 1 277 ? -7.67740  24.42194  35.97170 1.000 50.35974 ? 279 ARG A CB  1 
ATOM   2148 C CG  . ARG A 1 277 ? -8.23833  25.46326  35.00958 1.000 52.70528 ? 279 ARG A CG  1 
ATOM   2149 C CD  . ARG A 1 277 ? -7.36749  25.58127  33.76321 1.000 50.09263 ? 279 ARG A CD  1 
ATOM   2150 N NE  . ARG A 1 277 ? -6.37631  26.65030  33.90215 1.000 55.07779 ? 279 ARG A NE  1 
ATOM   2151 C CZ  . ARG A 1 277 ? -5.79155  27.27228  32.87684 1.000 59.24076 ? 279 ARG A CZ  1 
ATOM   2152 N NH1 . ARG A 1 277 ? -4.89534  28.23608  33.09836 1.000 54.13268 ? 279 ARG A NH1 1 
ATOM   2153 N NH2 . ARG A 1 277 ? -6.09394  26.91947  31.62617 1.000 53.52148 ? 279 ARG A NH2 1 
ATOM   2154 N N   . THR A 1 278 ? -8.54460  21.81024  37.37141 1.000 54.14553 ? 280 THR A N   1 
ATOM   2155 C CA  . THR A 1 278 ? -8.18086  20.49289  37.85238 1.000 50.87338 ? 280 THR A CA  1 
ATOM   2156 C C   . THR A 1 278 ? -7.49407  19.72448  36.73599 1.000 53.01005 ? 280 THR A C   1 
ATOM   2157 O O   . THR A 1 278 ? -7.59886  20.07022  35.55463 1.000 49.38811 ? 280 THR A O   1 
ATOM   2158 C CB  . THR A 1 278 ? -9.40857  19.70752  38.33594 1.000 50.61276 ? 280 THR A CB  1 
ATOM   2159 O OG1 . THR A 1 278 ? -10.23622 19.36624  37.21267 1.000 52.97731 ? 280 THR A OG1 1 
ATOM   2160 C CG2 . THR A 1 278 ? -10.20705 20.53316  39.32983 1.000 48.92986 ? 280 THR A CG2 1 
ATOM   2161 N N   . ILE A 1 279 ? -6.79576  18.66597  37.13013 1.000 46.89757 ? 281 ILE A N   1 
ATOM   2162 C CA  . ILE A 1 279 ? -6.16900  17.74117  36.20144 1.000 45.66849 ? 281 ILE A CA  1 
ATOM   2163 C C   . ILE A 1 279 ? -6.60137  16.34289  36.60968 1.000 47.46254 ? 281 ILE A C   1 
ATOM   2164 O O   . ILE A 1 279 ? -6.39139  15.94071  37.76085 1.000 48.75392 ? 281 ILE A O   1 
ATOM   2165 C CB  . ILE A 1 279 ? -4.63906  17.86595  36.21843 1.000 42.33071 ? 281 ILE A CB  1 
ATOM   2166 C CG1 . ILE A 1 279 ? -4.20773  19.26303  35.77712 1.000 43.61597 ? 281 ILE A CG1 1 
ATOM   2167 C CG2 . ILE A 1 279 ? -4.03386  16.83296  35.32128 1.000 42.05882 ? 281 ILE A CG2 1 
ATOM   2168 C CD1 . ILE A 1 279 ? -2.74842  19.57524  36.08380 1.000 40.96008 ? 281 ILE A CD1 1 
ATOM   2169 N N   . LEU A 1 280 ? -7.21450  15.61150  35.68148 1.000 45.54021 ? 282 LEU A N   1 
ATOM   2170 C CA  . LEU A 1 280 ? -7.75252  14.28139  35.96056 1.000 47.73238 ? 282 LEU A CA  1 
ATOM   2171 C C   . LEU A 1 280 ? -8.69952  14.30697  37.15417 1.000 53.38481 ? 282 LEU A C   1 
ATOM   2172 O O   . LEU A 1 280 ? -8.77093  13.34926  37.93237 1.000 53.47993 ? 282 LEU A O   1 
ATOM   2173 C CB  . LEU A 1 280 ? -6.63659  13.25869  36.18975 1.000 44.51067 ? 282 LEU A CB  1 
ATOM   2174 C CG  . LEU A 1 280 ? -5.93953  12.75891  34.92749 1.000 44.97931 ? 282 LEU A CG  1 
ATOM   2175 C CD1 . LEU A 1 280 ? -4.70863  11.93143  35.26944 1.000 36.35871 ? 282 LEU A CD1 1 
ATOM   2176 C CD2 . LEU A 1 280 ? -6.90621  11.96331  34.06987 1.000 42.16779 ? 282 LEU A CD2 1 
ATOM   2177 N N   . GLY A 1 281 ? -9.42272  15.40982  37.31354 1.000 52.21439 ? 283 GLY A N   1 
ATOM   2178 C CA  . GLY A 1 281 ? -10.38329 15.53026  38.38742 1.000 53.05095 ? 283 GLY A CA  1 
ATOM   2179 C C   . GLY A 1 281 ? -9.78252  15.79216  39.74223 1.000 54.96117 ? 283 GLY A C   1 
ATOM   2180 O O   . GLY A 1 281 ? -10.49111 15.68837  40.74799 1.000 60.31384 ? 283 GLY A O   1 
ATOM   2181 N N   . SER A 1 282 ? -8.49596  16.10696  39.80531 1.000 55.19224 ? 284 SER A N   1 
ATOM   2182 C CA  . SER A 1 282 ? -7.82502  16.42574  41.05208 1.000 48.45516 ? 284 SER A CA  1 
ATOM   2183 C C   . SER A 1 282 ? -7.33300  17.85802  40.99063 1.000 50.36286 ? 284 SER A C   1 
ATOM   2184 O O   . SER A 1 282 ? -6.91464  18.33626  39.93092 1.000 51.08681 ? 284 SER A O   1 
ATOM   2185 C CB  . SER A 1 282 ? -6.64378  15.48426  41.31404 1.000 46.64191 ? 284 SER A CB  1 
ATOM   2186 O OG  . SER A 1 282 ? -5.75430  16.04863  42.27131 1.000 46.68056 ? 284 SER A OG  1 
ATOM   2187 N N   . ALA A 1 283 ? -7.38344  18.54248  42.12490 1.000 47.41077 ? 285 ALA A N   1 
ATOM   2188 C CA  . ALA A 1 283 ? -6.84984  19.88885  42.21362 1.000 50.27301 ? 285 ALA A CA  1 
ATOM   2189 C C   . ALA A 1 283 ? -5.45429  19.90575  42.81315 1.000 46.17261 ? 285 ALA A C   1 
ATOM   2190 O O   . ALA A 1 283 ? -4.90740  20.98274  43.05844 1.000 46.55222 ? 285 ALA A O   1 
ATOM   2191 C CB  . ALA A 1 283 ? -7.80019  20.78048  43.01127 1.000 49.14284 ? 285 ALA A CB  1 
ATOM   2192 N N   . LEU A 1 284 ? -4.86165  18.73692  43.02953 1.000 43.51857 ? 286 LEU A N   1 
ATOM   2193 C CA  . LEU A 1 284 ? -3.49868  18.62525  43.51747 1.000 42.74794 ? 286 LEU A CA  1 
ATOM   2194 C C   . LEU A 1 284 ? -2.71032  17.72892  42.56980 1.000 40.51113 ? 286 LEU A C   1 
ATOM   2195 O O   . LEU A 1 284 ? -3.27805  16.93324  41.81760 1.000 41.44886 ? 286 LEU A O   1 
ATOM   2196 C CB  . LEU A 1 284 ? -3.46358  18.06885  44.93646 1.000 43.85729 ? 286 LEU A CB  1 
ATOM   2197 C CG  . LEU A 1 284 ? -3.83719  19.03672  46.07027 1.000 56.00850 ? 286 LEU A CG  1 
ATOM   2198 C CD1 . LEU A 1 284 ? -4.48968  18.27795  47.21086 1.000 55.11251 ? 286 LEU A CD1 1 
ATOM   2199 C CD2 . LEU A 1 284 ? -2.61783  19.81551  46.59512 1.000 49.80154 ? 286 LEU A CD2 1 
ATOM   2200 N N   . LEU A 1 285 ? -1.38939  17.87028  42.60231 1.000 33.61722 ? 287 LEU A N   1 
ATOM   2201 C CA  . LEU A 1 285 ? -0.52602  17.05749  41.75842 1.000 34.39586 ? 287 LEU A CA  1 
ATOM   2202 C C   . LEU A 1 285 ? -0.34757  15.68311  42.40987 1.000 36.13479 ? 287 LEU A C   1 
ATOM   2203 O O   . LEU A 1 285 ? 0.05657   15.58497  43.57162 1.000 40.64272 ? 287 LEU A O   1 
ATOM   2204 C CB  . LEU A 1 285 ? 0.80868   17.76448  41.53587 1.000 35.56576 ? 287 LEU A CB  1 
ATOM   2205 C CG  . LEU A 1 285 ? 0.64707   19.07854  40.74621 1.000 34.71880 ? 287 LEU A CG  1 
ATOM   2206 C CD1 . LEU A 1 285 ? 1.97329   19.71168  40.44852 1.000 34.23866 ? 287 LEU A CD1 1 
ATOM   2207 C CD2 . LEU A 1 285 ? -0.09093  18.83997  39.46786 1.000 39.56661 ? 287 LEU A CD2 1 
ATOM   2208 N N   . GLU A 1 286 ? -0.69455  14.62803  41.68559 1.000 32.81837 ? 288 GLU A N   1 
ATOM   2209 C CA  . GLU A 1 286 ? -0.69483  13.26724  42.22877 1.000 35.39169 ? 288 GLU A CA  1 
ATOM   2210 C C   . GLU A 1 286 ? 0.65659   12.59930  41.97537 1.000 33.35230 ? 288 GLU A C   1 
ATOM   2211 O O   . GLU A 1 286 ? 1.16535   12.63413  40.84939 1.000 31.64977 ? 288 GLU A O   1 
ATOM   2212 C CB  . GLU A 1 286 ? -1.83213  12.47524  41.57624 1.000 35.80849 ? 288 GLU A CB  1 
ATOM   2213 C CG  . GLU A 1 286 ? -1.83396  10.97149  41.81573 1.000 42.55250 ? 288 GLU A CG  1 
ATOM   2214 C CD  . GLU A 1 286 ? -1.92546  10.59511  43.28519 1.000 46.64752 ? 288 GLU A CD  1 
ATOM   2215 O OE1 . GLU A 1 286 ? -1.06397  9.82655   43.75454 1.000 43.66854 ? 288 GLU A OE1 1 
ATOM   2216 O OE2 . GLU A 1 286 ? -2.85935  11.08879  43.96575 1.000 53.34184 ? 288 GLU A OE2 1 
ATOM   2217 N N   . ASP A 1 287 ? 1.23637   11.96872  43.00968 1.000 34.84864 ? 289 ASP A N   1 
ATOM   2218 C CA  . ASP A 1 287 ? 2.56740   11.39312  42.83882 1.000 32.78113 ? 289 ASP A CA  1 
ATOM   2219 C C   . ASP A 1 287 ? 2.67020   9.91945   43.23536 1.000 32.87495 ? 289 ASP A C   1 
ATOM   2220 O O   . ASP A 1 287 ? 3.78258   9.43337   43.48078 1.000 30.53829 ? 289 ASP A O   1 
ATOM   2221 C CB  . ASP A 1 287 ? 3.61497   12.22936  43.58791 1.000 30.59642 ? 289 ASP A CB  1 
ATOM   2222 C CG  . ASP A 1 287 ? 3.70205   11.92321  45.07170 1.000 34.84316 ? 289 ASP A CG  1 
ATOM   2223 O OD1 . ASP A 1 287 ? 2.73079   11.41628  45.68384 1.000 35.62231 ? 289 ASP A OD1 1 
ATOM   2224 O OD2 . ASP A 1 287 ? 4.77345   12.23048  45.64181 1.000 31.94768 ? 289 ASP A OD2 1 
ATOM   2225 N N   . GLU A 1 288 ? 1.56074   9.17847   43.27878 1.000 30.76106 ? 290 GLU A N   1 
ATOM   2226 C CA  . GLU A 1 288 ? 1.62626   7.75988   43.62456 1.000 34.66715 ? 290 GLU A CA  1 
ATOM   2227 C C   . GLU A 1 288 ? 1.30452   6.85826   42.43672 1.000 35.23108 ? 290 GLU A C   1 
ATOM   2228 O O   . GLU A 1 288 ? 0.95361   5.69323   42.63225 1.000 30.21973 ? 290 GLU A O   1 
ATOM   2229 C CB  . GLU A 1 288 ? 0.72031   7.44673   44.82489 1.000 32.16112 ? 290 GLU A CB  1 
ATOM   2230 C CG  . GLU A 1 288 ? 1.09022   8.28555   46.08189 1.000 38.08628 ? 290 GLU A CG  1 
ATOM   2231 C CD  . GLU A 1 288 ? 1.07141   7.52043   47.42354 1.000 37.13045 ? 290 GLU A CD  1 
ATOM   2232 O OE1 . GLU A 1 288 ? 0.59438   6.36114   47.46421 1.000 40.76915 ? 290 GLU A OE1 1 
ATOM   2233 O OE2 . GLU A 1 288 ? 1.53558   8.09501   48.44662 1.000 33.66578 ? 290 GLU A OE2 1 
ATOM   2234 N N   . PHE A 1 289 ? 1.43871   7.37013   41.20813 1.000 30.26187 ? 291 PHE A N   1 
ATOM   2235 C CA  . PHE A 1 289 ? 1.40792   6.55737   39.99130 1.000 33.70933 ? 291 PHE A CA  1 
ATOM   2236 C C   . PHE A 1 289 ? 2.79364   6.53656   39.35994 1.000 35.49790 ? 291 PHE A C   1 
ATOM   2237 O O   . PHE A 1 289 ? 3.28709   7.58075   38.91416 1.000 31.96917 ? 291 PHE A O   1 
ATOM   2238 C CB  . PHE A 1 289 ? 0.41803   7.10680   38.96969 1.000 33.86793 ? 291 PHE A CB  1 
ATOM   2239 C CG  . PHE A 1 289 ? -1.00409  6.95170   39.36376 1.000 39.01791 ? 291 PHE A CG  1 
ATOM   2240 C CD1 . PHE A 1 289 ? -1.69422  5.78501   39.05764 1.000 35.60439 ? 291 PHE A CD1 1 
ATOM   2241 C CD2 . PHE A 1 289 ? -1.66016  7.96281   40.04175 1.000 36.08701 ? 291 PHE A CD2 1 
ATOM   2242 C CE1 . PHE A 1 289 ? -3.02147  5.63157   39.41077 1.000 38.91638 ? 291 PHE A CE1 1 
ATOM   2243 C CE2 . PHE A 1 289 ? -2.99755  7.82444   40.39873 1.000 39.71039 ? 291 PHE A CE2 1 
ATOM   2244 C CZ  . PHE A 1 289 ? -3.67689  6.64921   40.08605 1.000 42.62491 ? 291 PHE A CZ  1 
ATOM   2245 N N   . THR A 1 290 ? 3.40622   5.35624   39.29600 1.000 31.55206 ? 292 THR A N   1 
ATOM   2246 C CA  . THR A 1 290 ? 4.66013   5.21598   38.57292 1.000 31.02117 ? 292 THR A CA  1 
ATOM   2247 C C   . THR A 1 290 ? 4.42304   5.31153   37.06642 1.000 29.52692 ? 292 THR A C   1 
ATOM   2248 O O   . THR A 1 290 ? 3.29480   5.15623   36.59041 1.000 27.19987 ? 292 THR A O   1 
ATOM   2249 C CB  . THR A 1 290 ? 5.32533   3.87591   38.88365 1.000 33.37806 ? 292 THR A CB  1 
ATOM   2250 O OG1 . THR A 1 290 ? 4.51315   2.81860   38.36234 1.000 31.90004 ? 292 THR A OG1 1 
ATOM   2251 C CG2 . THR A 1 290 ? 5.51362   3.69411   40.36245 1.000 33.25810 ? 292 THR A CG2 1 
ATOM   2252 N N   . PRO A 1 291 ? 5.48307   5.55141   36.28802 1.000 28.46541 ? 293 PRO A N   1 
ATOM   2253 C CA  . PRO A 1 291 ? 5.33847   5.42197   34.83101 1.000 28.62536 ? 293 PRO A CA  1 
ATOM   2254 C C   . PRO A 1 291 ? 4.82690   4.04842   34.40687 1.000 31.16918 ? 293 PRO A C   1 
ATOM   2255 O O   . PRO A 1 291 ? 4.01087   3.96111   33.48431 1.000 28.98256 ? 293 PRO A O   1 
ATOM   2256 C CB  . PRO A 1 291 ? 6.76003   5.69973   34.31615 1.000 27.99079 ? 293 PRO A CB  1 
ATOM   2257 C CG  . PRO A 1 291 ? 7.40296   6.49906   35.39068 1.000 25.02826 ? 293 PRO A CG  1 
ATOM   2258 C CD  . PRO A 1 291 ? 6.85318   5.94148   36.66969 1.000 30.16047 ? 293 PRO A CD  1 
ATOM   2259 N N   . PHE A 1 292 ? 5.26080   2.97370   35.07915 1.000 31.42989 ? 294 PHE A N   1 
ATOM   2260 C CA  . PHE A 1 292 ? 4.76887   1.63512   34.74980 1.000 35.75177 ? 294 PHE A CA  1 
ATOM   2261 C C   . PHE A 1 292 ? 3.26473   1.51598   34.98888 1.000 35.62435 ? 294 PHE A C   1 
ATOM   2262 O O   . PHE A 1 292 ? 2.53565   0.97554   34.15184 1.000 35.38541 ? 294 PHE A O   1 
ATOM   2263 C CB  . PHE A 1 292 ? 5.52673   0.58151   35.56377 1.000 39.10254 ? 294 PHE A CB  1 
ATOM   2264 C CG  . PHE A 1 292 ? 5.08817   -0.84611  35.27997 1.000 49.87431 ? 294 PHE A CG  1 
ATOM   2265 C CD1 . PHE A 1 292 ? 4.00479   -1.41406  35.95621 1.000 50.20745 ? 294 PHE A CD1 1 
ATOM   2266 C CD2 . PHE A 1 292 ? 5.76189   -1.61843  34.33915 1.000 50.50916 ? 294 PHE A CD2 1 
ATOM   2267 C CE1 . PHE A 1 292 ? 3.60056   -2.72440  35.69688 1.000 51.08981 ? 294 PHE A CE1 1 
ATOM   2268 C CE2 . PHE A 1 292 ? 5.36095   -2.92951  34.07682 1.000 54.22889 ? 294 PHE A CE2 1 
ATOM   2269 C CZ  . PHE A 1 292 ? 4.27818   -3.47660  34.75505 1.000 50.22066 ? 294 PHE A CZ  1 
ATOM   2270 N N   . ASP A 1 293 ? 2.79366   1.98430   36.14879 1.000 34.68193 ? 295 ASP A N   1 
ATOM   2271 C CA  . ASP A 1 293 ? 1.36370   1.99658   36.45476 1.000 33.27514 ? 295 ASP A CA  1 
ATOM   2272 C C   . ASP A 1 293 ? 0.55322   2.69024   35.36042 1.000 40.41703 ? 295 ASP A C   1 
ATOM   2273 O O   . ASP A 1 293 ? -0.47780  2.17151   34.90456 1.000 37.80515 ? 295 ASP A O   1 
ATOM   2274 C CB  . ASP A 1 293 ? 1.12503   2.69343   37.79642 1.000 35.86486 ? 295 ASP A CB  1 
ATOM   2275 C CG  . ASP A 1 293 ? 1.72767   1.93316   38.98017 1.000 41.27996 ? 295 ASP A CG  1 
ATOM   2276 O OD1 . ASP A 1 293 ? 1.95673   0.70378   38.86440 1.000 45.56300 ? 295 ASP A OD1 1 
ATOM   2277 O OD2 . ASP A 1 293 ? 1.98382   2.57915   40.02686 1.000 36.58418 ? 295 ASP A OD2 1 
ATOM   2278 N N   . VAL A 1 294 ? 0.99586   3.87678   34.93508 1.000 33.74241 ? 296 VAL A N   1 
ATOM   2279 C CA  . VAL A 1 294 ? 0.26271   4.61256   33.90610 1.000 33.64760 ? 296 VAL A CA  1 
ATOM   2280 C C   . VAL A 1 294 ? 0.22907   3.82463   32.60293 1.000 38.62915 ? 296 VAL A C   1 
ATOM   2281 O O   . VAL A 1 294 ? -0.80594  3.75576   31.92911 1.000 42.13245 ? 296 VAL A O   1 
ATOM   2282 C CB  . VAL A 1 294 ? 0.87877   6.00620   33.69020 1.000 29.26838 ? 296 VAL A CB  1 
ATOM   2283 C CG1 . VAL A 1 294 ? 0.15472   6.74267   32.55010 1.000 32.62703 ? 296 VAL A CG1 1 
ATOM   2284 C CG2 . VAL A 1 294 ? 0.83436   6.81066   34.96709 1.000 31.54017 ? 296 VAL A CG2 1 
ATOM   2285 N N   . VAL A 1 295 ? 1.36907   3.26123   32.20155 1.000 36.28564 ? 297 VAL A N   1 
ATOM   2286 C CA  . VAL A 1 295 ? 1.42262   2.51121   30.95063 1.000 39.96968 ? 297 VAL A CA  1 
ATOM   2287 C C   . VAL A 1 295 ? 0.47809   1.31981   31.01634 1.000 43.42112 ? 297 VAL A C   1 
ATOM   2288 O O   . VAL A 1 295 ? -0.30967  1.08222   30.09630 1.000 46.08718 ? 297 VAL A O   1 
ATOM   2289 C CB  . VAL A 1 295 ? 2.86810   2.08013   30.64720 1.000 41.17586 ? 297 VAL A CB  1 
ATOM   2290 C CG1 . VAL A 1 295 ? 2.88770   0.82792   29.80396 1.000 42.07351 ? 297 VAL A CG1 1 
ATOM   2291 C CG2 . VAL A 1 295 ? 3.61194   3.20651   29.95425 1.000 41.26434 ? 297 VAL A CG2 1 
ATOM   2292 N N   . ARG A 1 296 ? 0.51886   0.57549   32.12409 1.000 41.66846 ? 298 ARG A N   1 
ATOM   2293 C CA  . ARG A 1 296 ? -0.36190  -0.58134  32.27554 1.000 46.63629 ? 298 ARG A CA  1 
ATOM   2294 C C   . ARG A 1 296 ? -1.82823  -0.17248  32.22294 1.000 48.24774 ? 298 ARG A C   1 
ATOM   2295 O O   . ARG A 1 296 ? -2.62849  -0.80311  31.52235 1.000 47.92418 ? 298 ARG A O   1 
ATOM   2296 C CB  . ARG A 1 296 ? -0.05308  -1.32501  33.58022 1.000 45.67001 ? 298 ARG A CB  1 
ATOM   2297 C CG  . ARG A 1 296 ? -1.28255  -1.94405  34.27321 1.000 53.42156 ? 298 ARG A CG  1 
ATOM   2298 C CD  . ARG A 1 296 ? -0.91386  -2.90116  35.41531 1.000 53.14901 ? 298 ARG A CD  1 
ATOM   2299 N NE  . ARG A 1 296 ? -1.06510  -2.30284  36.74951 1.000 63.97705 ? 298 ARG A NE  1 
ATOM   2300 C CZ  . ARG A 1 296 ? -2.11061  -2.48225  37.56490 1.000 57.16602 ? 298 ARG A CZ  1 
ATOM   2301 N NH1 . ARG A 1 296 ? -2.13519  -1.89365  38.76015 1.000 49.49763 ? 298 ARG A NH1 1 
ATOM   2302 N NH2 . ARG A 1 296 ? -3.13292  -3.24097  37.19526 1.000 52.94326 ? 298 ARG A NH2 1 
ATOM   2303 N N   . GLN A 1 297 ? -2.20040  0.89244   32.93598 1.000 45.73917 ? 299 GLN A N   1 
ATOM   2304 C CA  . GLN A 1 297 ? -3.60612  1.27822   32.98417 1.000 45.17850 ? 299 GLN A CA  1 
ATOM   2305 C C   . GLN A 1 297 ? -4.07678  1.91212   31.68386 1.000 46.17853 ? 299 GLN A C   1 
ATOM   2306 O O   . GLN A 1 297 ? -5.27662  1.87161   31.39042 1.000 47.99581 ? 299 GLN A O   1 
ATOM   2307 C CB  . GLN A 1 297 ? -3.88104  2.23343   34.15614 1.000 41.76883 ? 299 GLN A CB  1 
ATOM   2308 C CG  . GLN A 1 297 ? -5.36878  2.59862   34.31278 1.000 38.34909 ? 299 GLN A CG  1 
ATOM   2309 C CD  . GLN A 1 297 ? -5.70019  3.26001   35.64412 1.000 43.33810 ? 299 GLN A CD  1 
ATOM   2310 O OE1 . GLN A 1 297 ? -6.81511  3.74948   35.85162 1.000 41.57883 ? 299 GLN A OE1 1 
ATOM   2311 N NE2 . GLN A 1 297 ? -4.73280  3.27550   36.55447 1.000 42.49825 ? 299 GLN A NE2 1 
ATOM   2312 N N   . CYS A 1 298 ? -3.17060  2.47146   30.88881 1.000 47.30445 ? 300 CYS A N   1 
ATOM   2313 C CA  . CYS A 1 298 ? -3.53573  3.09131   29.62122 1.000 50.02295 ? 300 CYS A CA  1 
ATOM   2314 C C   . CYS A 1 298 ? -3.21017  2.21950   28.40274 1.000 51.09116 ? 300 CYS A C   1 
ATOM   2315 O O   . CYS A 1 298 ? -3.47448  2.64021   27.27304 1.000 58.36261 ? 300 CYS A O   1 
ATOM   2316 C CB  . CYS A 1 298 ? -2.85791  4.46880   29.50475 1.000 44.68276 ? 300 CYS A CB  1 
ATOM   2317 S SG  . CYS A 1 298 ? -3.32684  5.69246   30.82945 1.000 49.43049 ? 300 CYS A SG  1 
ATOM   2318 N N   . SER A 1 299 ? -2.67575  1.01185   28.60186 1.000 57.47924 ? 301 SER A N   1 
ATOM   2319 C CA  . SER A 1 299 ? -2.37629  0.07950   27.50332 1.000 52.67052 ? 301 SER A CA  1 
ATOM   2320 C C   . SER A 1 299 ? -3.25844  -1.15874  27.54763 1.000 52.16179 ? 301 SER A C   1 
ATOM   2321 O O   . SER A 1 299 ? -2.84714  -2.21064  28.05366 1.000 57.82078 ? 301 SER A O   1 
ATOM   2322 C CB  . SER A 1 299 ? -0.90369  -0.35904  27.53723 1.000 57.21459 ? 301 SER A CB  1 
ATOM   2323 O OG  . SER A 1 299 ? -0.72731  -1.60514  28.22014 1.000 61.37397 ? 301 SER A OG  1 
HETATM 2324 C C02 . X77 B 2 .   ? -1.39653  -2.70087  66.47828 1.000 33.47881 ? 401 X77 A C02 1 
HETATM 2325 C C04 . X77 B 2 .   ? -0.80758  -0.25989  66.16259 1.000 33.72242 ? 401 X77 A C04 1 
HETATM 2326 C C05 . X77 B 2 .   ? 0.39562   0.63356   66.24918 1.000 32.43589 ? 401 X77 A C05 1 
HETATM 2327 C C07 . X77 B 2 .   ? 1.49488   2.57071   67.41354 1.000 34.35409 ? 401 X77 A C07 1 
HETATM 2328 C C08 . X77 B 2 .   ? 0.96886   3.91029   67.93320 1.000 39.53057 ? 401 X77 A C08 1 
HETATM 2329 C C09 . X77 B 2 .   ? 2.10164   4.87402   68.27066 1.000 38.46302 ? 401 X77 A C09 1 
HETATM 2330 C C10 . X77 B 2 .   ? 3.03761   4.23737   69.29499 1.000 38.89931 ? 401 X77 A C10 1 
HETATM 2331 C C11 . X77 B 2 .   ? 3.52801   2.82580   68.94164 1.000 34.53450 ? 401 X77 A C11 1 
HETATM 2332 C C12 . X77 B 2 .   ? 2.50108   1.88174   68.33152 1.000 34.71524 ? 401 X77 A C12 1 
HETATM 2333 C C14 . X77 B 2 .   ? -1.30456  0.00950   64.74985 1.000 34.54199 ? 401 X77 A C14 1 
HETATM 2334 C C15 . X77 B 2 .   ? -2.43527  0.97162   64.60707 1.000 32.11806 ? 401 X77 A C15 1 
HETATM 2335 C C16 . X77 B 2 .   ? -2.95414  1.30547   63.25057 1.000 33.63542 ? 401 X77 A C16 1 
HETATM 2336 C C17 . X77 B 2 .   ? -2.29822  0.66896   62.02922 1.000 36.14333 ? 401 X77 A C17 1 
HETATM 2337 C C19 . X77 B 2 .   ? -0.63706  -0.62773  63.53639 1.000 30.77009 ? 401 X77 A C19 1 
HETATM 2338 C C20 . X77 B 2 .   ? 0.93372   -1.80846  67.08232 1.000 31.39967 ? 401 X77 A C20 1 
HETATM 2339 C C21 . X77 B 2 .   ? 1.08042   -1.53064  68.57555 1.000 35.13331 ? 401 X77 A C21 1 
HETATM 2340 C C22 . X77 B 2 .   ? 2.44386   -1.67404  69.24758 1.000 35.24272 ? 401 X77 A C22 1 
HETATM 2341 C C23 . X77 B 2 .   ? 3.62957   -2.11113  68.37532 1.000 35.63234 ? 401 X77 A C23 1 
HETATM 2342 C C24 . X77 B 2 .   ? 4.97499   -2.26729  69.07494 1.000 37.89367 ? 401 X77 A C24 1 
HETATM 2343 C C25 . X77 B 2 .   ? 4.87034   -3.42003  70.06302 1.000 42.04583 ? 401 X77 A C25 1 
HETATM 2344 C C26 . X77 B 2 .   ? 5.24694   -0.96018  69.78235 1.000 36.92591 ? 401 X77 A C26 1 
HETATM 2345 C C27 . X77 B 2 .   ? 6.06827   -2.59730  68.03963 1.000 34.82934 ? 401 X77 A C27 1 
HETATM 2346 C C28 . X77 B 2 .   ? 3.48417   -2.40485  66.88641 1.000 32.94048 ? 401 X77 A C28 1 
HETATM 2347 C C29 . X77 B 2 .   ? 2.11641   -2.25512  66.21427 1.000 30.59181 ? 401 X77 A C29 1 
HETATM 2348 C C30 . X77 B 2 .   ? -1.07661  -4.14433  66.90912 1.000 30.24061 ? 401 X77 A C30 1 
HETATM 2349 C C31 . X77 B 2 .   ? 0.07710   -4.60847  67.49301 1.000 30.97370 ? 401 X77 A C31 1 
HETATM 2350 C C33 . X77 B 2 .   ? -1.28001  -6.25480  67.26379 1.000 34.33442 ? 401 X77 A C33 1 
HETATM 2351 N N03 . X77 B 2 .   ? -0.41210  -1.61791  66.52851 1.000 29.80635 ? 401 X77 A N03 1 
HETATM 2352 N N06 . X77 B 2 .   ? 0.36659   1.65268   67.28744 1.000 29.55935 ? 401 X77 A N06 1 
HETATM 2353 N N18 . X77 B 2 .   ? -1.15818  -0.27974  62.19591 1.000 33.19920 ? 401 X77 A N18 1 
HETATM 2354 N N32 . X77 B 2 .   ? -0.06518  -5.89456  67.70375 1.000 33.02790 ? 401 X77 A N32 1 
HETATM 2355 N N34 . X77 B 2 .   ? -1.90125  -5.15762  66.77698 1.000 33.53487 ? 401 X77 A N34 1 
HETATM 2356 O O01 . X77 B 2 .   ? -2.46021  -2.41487  66.07406 1.000 36.67851 ? 401 X77 A O01 1 
HETATM 2357 O O13 . X77 B 2 .   ? 1.28884   0.55141   65.46911 1.000 31.14509 ? 401 X77 A O13 1 
HETATM 2358 O O   . HOH C 3 .   ? -1.01764  -22.84024 64.68006 1.000 59.37564 ? 501 HOH A O   1 
HETATM 2359 O O   . HOH C 3 .   ? 9.17748   11.11799  51.61185 1.000 40.14402 ? 502 HOH A O   1 
HETATM 2360 O O   . HOH C 3 .   ? 2.12399   23.96529  31.93044 1.000 53.94817 ? 503 HOH A O   1 
HETATM 2361 O O   . HOH C 3 .   ? 2.79513   -16.25869 75.95679 1.000 51.36198 ? 504 HOH A O   1 
HETATM 2362 O O   . HOH C 3 .   ? 9.924     30.555    23.160   1.000 49.74208 ? 505 HOH A O   1 
HETATM 2363 O O   . HOH C 3 .   ? 15.78199  11.63444  42.43618 1.000 42.60793 ? 506 HOH A O   1 
HETATM 2364 O O   . HOH C 3 .   ? 2.15445   5.92545   50.57197 1.000 33.83863 ? 507 HOH A O   1 
HETATM 2365 O O   . HOH C 3 .   ? 18.40231  -0.66514  46.47774 1.000 61.19866 ? 508 HOH A O   1 
HETATM 2366 O O   . HOH C 3 .   ? 1.85595   -1.79157  38.66742 1.000 50.53456 ? 509 HOH A O   1 
HETATM 2367 O O   . HOH C 3 .   ? -2.08977  -9.28426  53.30212 1.000 36.83981 ? 510 HOH A O   1 
HETATM 2368 O O   . HOH C 3 .   ? 8.87699   1.71924   56.64690 1.000 26.53259 ? 511 HOH A O   1 
HETATM 2369 O O   . HOH C 3 .   ? -4.45697  -17.39877 66.04223 1.000 44.37011 ? 512 HOH A O   1 
HETATM 2370 O O   . HOH C 3 .   ? -3.12074  -18.33005 47.21997 1.000 37.75988 ? 513 HOH A O   1 
HETATM 2371 O O   . HOH C 3 .   ? 17.64671  -5.11674  59.44295 1.000 39.05399 ? 514 HOH A O   1 
HETATM 2372 O O   . HOH C 3 .   ? 4.69294   -6.31148  38.15428 1.000 53.34424 ? 515 HOH A O   1 
HETATM 2373 O O   . HOH C 3 .   ? 10.71197  -8.61831  50.64839 1.000 33.68649 ? 516 HOH A O   1 
HETATM 2374 O O   . HOH C 3 .   ? 19.69142  -7.99779  57.27844 1.000 34.24139 ? 517 HOH A O   1 
HETATM 2375 O O   . HOH C 3 .   ? -5.73459  -8.88976  63.41042 1.000 35.29024 ? 518 HOH A O   1 
HETATM 2376 O O   . HOH C 3 .   ? 12.66269  8.72725   57.17853 1.000 35.90110 ? 519 HOH A O   1 
HETATM 2377 O O   . HOH C 3 .   ? 1.73122   9.96634   40.07692 1.000 28.78759 ? 520 HOH A O   1 
HETATM 2378 O O   . HOH C 3 .   ? 2.11421   -7.01431  69.09664 1.000 34.42493 ? 521 HOH A O   1 
HETATM 2379 O O   . HOH C 3 .   ? 7.97883   -6.49977  64.81120 1.000 25.94375 ? 522 HOH A O   1 
HETATM 2380 O O   . HOH C 3 .   ? 12.69209  -14.70858 47.05258 1.000 37.74094 ? 523 HOH A O   1 
HETATM 2381 O O   . HOH C 3 .   ? 12.35977  -7.31349  76.83040 1.000 37.67364 ? 524 HOH A O   1 
HETATM 2382 O O   . HOH C 3 .   ? 8.38612   -20.17844 53.02572 1.000 39.47022 ? 525 HOH A O   1 
HETATM 2383 O O   . HOH C 3 .   ? -8.99691  -17.06743 61.20745 1.000 56.34352 ? 526 HOH A O   1 
HETATM 2384 O O   . HOH C 3 .   ? 10.44463  -14.16628 37.31199 1.000 56.18599 ? 527 HOH A O   1 
HETATM 2385 O O   . HOH C 3 .   ? 15.30877  -3.72012  60.36982 1.000 32.12016 ? 528 HOH A O   1 
HETATM 2386 O O   . HOH C 3 .   ? -0.65300  -19.50057 72.56980 1.000 53.23108 ? 529 HOH A O   1 
HETATM 2387 O O   . HOH C 3 .   ? 6.88785   -6.01552  44.87390 1.000 36.96069 ? 530 HOH A O   1 
HETATM 2388 O O   . HOH C 3 .   ? -4.01263  -12.89587 42.36323 1.000 43.15159 ? 531 HOH A O   1 
HETATM 2389 O O   . HOH C 3 .   ? 14.98482  0.62190   49.48204 1.000 40.98788 ? 532 HOH A O   1 
HETATM 2390 O O   . HOH C 3 .   ? 15.89672  -16.87229 66.21812 1.000 34.02453 ? 533 HOH A O   1 
HETATM 2391 O O   . HOH C 3 .   ? 18.45818  -6.42655  61.84552 1.000 49.65504 ? 534 HOH A O   1 
HETATM 2392 O O   . HOH C 3 .   ? 7.46902   17.79779  22.67173 1.000 36.23873 ? 535 HOH A O   1 
HETATM 2393 O O   . HOH C 3 .   ? 7.21827   15.33390  56.12722 1.000 47.95213 ? 536 HOH A O   1 
HETATM 2394 O O   . HOH C 3 .   ? 13.71106  6.19245   26.84958 1.000 38.68569 ? 537 HOH A O   1 
HETATM 2395 O O   . HOH C 3 .   ? 15.10719  -6.76199  45.95340 1.000 40.48428 ? 538 HOH A O   1 
HETATM 2396 O O   . HOH C 3 .   ? -6.37994  1.33142   44.99744 1.000 36.24242 ? 539 HOH A O   1 
HETATM 2397 O O   . HOH C 3 .   ? -7.60041  -23.38982 55.87386 1.000 50.50159 ? 540 HOH A O   1 
HETATM 2398 O O   . HOH C 3 .   ? 5.68247   10.89050  56.39121 1.000 39.66312 ? 541 HOH A O   1 
HETATM 2399 O O   . HOH C 3 .   ? 15.79843  -17.55152 60.82291 1.000 48.93653 ? 542 HOH A O   1 
HETATM 2400 O O   . HOH C 3 .   ? 16.20229  0.62983   51.55979 1.000 46.51725 ? 543 HOH A O   1 
HETATM 2401 O O   . HOH C 3 .   ? 11.85609  11.70326  40.86307 1.000 33.29620 ? 544 HOH A O   1 
HETATM 2402 O O   . HOH C 3 .   ? -1.82389  -28.79399 61.94066 1.000 51.15941 ? 545 HOH A O   1 
HETATM 2403 O O   . HOH C 3 .   ? -8.22328  17.14064  44.73039 0.50  48.89949 ? 546 HOH A O   1 
HETATM 2404 O O   . HOH C 3 .   ? 8.68510   -26.54011 52.47277 1.000 54.40684 ? 547 HOH A O   1 
HETATM 2405 O O   . HOH C 3 .   ? -7.82229  -17.07804 59.11701 1.000 41.78397 ? 548 HOH A O   1 
HETATM 2406 O O   . HOH C 3 .   ? 13.59743  -21.70071 69.34964 1.000 52.73132 ? 549 HOH A O   1 
HETATM 2407 O O   . HOH C 3 .   ? -6.14331  -20.62102 53.23709 1.000 52.08491 ? 550 HOH A O   1 
HETATM 2408 O O   . HOH C 3 .   ? 9.70974   18.61718  22.03228 1.000 45.67817 ? 551 HOH A O   1 
# 
