data_8YKP
# 
_entry.id   8YKP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YKP         pdb_00008ykp 10.2210/pdb8ykp/pdb 
WWPDB D_1300043867 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YKP 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rmsl_2040@163.com 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9511-4219 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zou, X.F.' 1 ? 
'Zhang, J.' 2 ? 
'Li, J.'    3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            276 
_citation.language                  ? 
_citation.page_first                133706 
_citation.page_last                 133706 
_citation.title                     
'Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.133706 
_citation.pdbx_database_id_PubMed   38981557 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jiang, H.' 1 ? 
primary 'Li, W.'    2 ? 
primary 'Zhou, X.'  3 ? 
primary 'Zhang, J.' 4 ? 
primary 'Li, J.'    5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                                    
33286.977 1  3.4.22.69 M49I ? ? 
2 non-polymer syn 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' 
459.583   1  ?         ?    ? ? 
3 water       nat water                                                                                                        
18.015    16 ?         ?    ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDILNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDILNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGV
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' X77 
3 water                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PHE n 
1 2   ARG n 
1 3   LYS n 
1 4   MET n 
1 5   ALA n 
1 6   PHE n 
1 7   PRO n 
1 8   SER n 
1 9   GLY n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  GLY n 
1 14  CYS n 
1 15  MET n 
1 16  VAL n 
1 17  GLN n 
1 18  VAL n 
1 19  THR n 
1 20  CYS n 
1 21  GLY n 
1 22  THR n 
1 23  THR n 
1 24  THR n 
1 25  LEU n 
1 26  ASN n 
1 27  GLY n 
1 28  LEU n 
1 29  TRP n 
1 30  LEU n 
1 31  ASP n 
1 32  ASP n 
1 33  VAL n 
1 34  VAL n 
1 35  TYR n 
1 36  CYS n 
1 37  PRO n 
1 38  ARG n 
1 39  HIS n 
1 40  VAL n 
1 41  ILE n 
1 42  CYS n 
1 43  THR n 
1 44  SER n 
1 45  GLU n 
1 46  ASP n 
1 47  ILE n 
1 48  LEU n 
1 49  ASN n 
1 50  PRO n 
1 51  ASN n 
1 52  TYR n 
1 53  GLU n 
1 54  ASP n 
1 55  LEU n 
1 56  LEU n 
1 57  ILE n 
1 58  ARG n 
1 59  LYS n 
1 60  SER n 
1 61  ASN n 
1 62  HIS n 
1 63  ASN n 
1 64  PHE n 
1 65  LEU n 
1 66  VAL n 
1 67  GLN n 
1 68  ALA n 
1 69  GLY n 
1 70  ASN n 
1 71  VAL n 
1 72  GLN n 
1 73  LEU n 
1 74  ARG n 
1 75  VAL n 
1 76  ILE n 
1 77  GLY n 
1 78  HIS n 
1 79  SER n 
1 80  MET n 
1 81  GLN n 
1 82  ASN n 
1 83  CYS n 
1 84  VAL n 
1 85  LEU n 
1 86  LYS n 
1 87  LEU n 
1 88  LYS n 
1 89  VAL n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  ASN n 
1 94  PRO n 
1 95  LYS n 
1 96  THR n 
1 97  PRO n 
1 98  LYS n 
1 99  TYR n 
1 100 LYS n 
1 101 PHE n 
1 102 VAL n 
1 103 ARG n 
1 104 ILE n 
1 105 GLN n 
1 106 PRO n 
1 107 GLY n 
1 108 GLN n 
1 109 THR n 
1 110 PHE n 
1 111 SER n 
1 112 VAL n 
1 113 LEU n 
1 114 ALA n 
1 115 CYS n 
1 116 TYR n 
1 117 ASN n 
1 118 GLY n 
1 119 SER n 
1 120 PRO n 
1 121 SER n 
1 122 GLY n 
1 123 VAL n 
1 124 TYR n 
1 125 GLN n 
1 126 CYS n 
1 127 ALA n 
1 128 MET n 
1 129 ARG n 
1 130 PRO n 
1 131 ASN n 
1 132 PHE n 
1 133 THR n 
1 134 ILE n 
1 135 LYS n 
1 136 GLY n 
1 137 SER n 
1 138 PHE n 
1 139 LEU n 
1 140 ASN n 
1 141 GLY n 
1 142 SER n 
1 143 CYS n 
1 144 GLY n 
1 145 SER n 
1 146 VAL n 
1 147 GLY n 
1 148 PHE n 
1 149 ASN n 
1 150 ILE n 
1 151 ASP n 
1 152 TYR n 
1 153 ASP n 
1 154 CYS n 
1 155 VAL n 
1 156 SER n 
1 157 PHE n 
1 158 CYS n 
1 159 TYR n 
1 160 MET n 
1 161 HIS n 
1 162 HIS n 
1 163 MET n 
1 164 GLU n 
1 165 LEU n 
1 166 PRO n 
1 167 THR n 
1 168 GLY n 
1 169 VAL n 
1 170 HIS n 
1 171 ALA n 
1 172 GLY n 
1 173 THR n 
1 174 ASP n 
1 175 LEU n 
1 176 GLU n 
1 177 GLY n 
1 178 ASN n 
1 179 PHE n 
1 180 TYR n 
1 181 GLY n 
1 182 PRO n 
1 183 PHE n 
1 184 VAL n 
1 185 ASP n 
1 186 ARG n 
1 187 GLN n 
1 188 THR n 
1 189 ALA n 
1 190 GLN n 
1 191 ALA n 
1 192 ALA n 
1 193 GLY n 
1 194 THR n 
1 195 ASP n 
1 196 THR n 
1 197 THR n 
1 198 ILE n 
1 199 THR n 
1 200 VAL n 
1 201 ASN n 
1 202 VAL n 
1 203 LEU n 
1 204 ALA n 
1 205 TRP n 
1 206 LEU n 
1 207 TYR n 
1 208 ALA n 
1 209 ALA n 
1 210 VAL n 
1 211 ILE n 
1 212 ASN n 
1 213 GLY n 
1 214 ASP n 
1 215 ARG n 
1 216 TRP n 
1 217 PHE n 
1 218 LEU n 
1 219 ASN n 
1 220 ARG n 
1 221 PHE n 
1 222 THR n 
1 223 THR n 
1 224 THR n 
1 225 LEU n 
1 226 ASN n 
1 227 ASP n 
1 228 PHE n 
1 229 ASN n 
1 230 LEU n 
1 231 VAL n 
1 232 ALA n 
1 233 MET n 
1 234 LYS n 
1 235 TYR n 
1 236 ASN n 
1 237 TYR n 
1 238 GLU n 
1 239 PRO n 
1 240 LEU n 
1 241 THR n 
1 242 GLN n 
1 243 ASP n 
1 244 HIS n 
1 245 VAL n 
1 246 ASP n 
1 247 ILE n 
1 248 LEU n 
1 249 GLY n 
1 250 PRO n 
1 251 LEU n 
1 252 SER n 
1 253 ALA n 
1 254 GLN n 
1 255 THR n 
1 256 GLY n 
1 257 ILE n 
1 258 ALA n 
1 259 VAL n 
1 260 LEU n 
1 261 ASP n 
1 262 MET n 
1 263 CYS n 
1 264 ALA n 
1 265 SER n 
1 266 LEU n 
1 267 LYS n 
1 268 GLU n 
1 269 LEU n 
1 270 LEU n 
1 271 GLN n 
1 272 ASN n 
1 273 GLY n 
1 274 MET n 
1 275 ASN n 
1 276 GLY n 
1 277 ARG n 
1 278 THR n 
1 279 ILE n 
1 280 LEU n 
1 281 GLY n 
1 282 SER n 
1 283 ALA n 
1 284 LEU n 
1 285 LEU n 
1 286 GLU n 
1 287 ASP n 
1 288 GLU n 
1 289 PHE n 
1 290 THR n 
1 291 PRO n 
1 292 PHE n 
1 293 ASP n 
1 294 VAL n 
1 295 VAL n 
1 296 ARG n 
1 297 GLN n 
1 298 CYS n 
1 299 SER n 
1 300 GLY n 
1 301 VAL n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   301 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
X77 non-polymer         . 
'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' ? 'C27 H33 N5 O2'  
459.583 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PHE 1   3   3   PHE PHE A . n 
A 1 2   ARG 2   4   4   ARG ARG A . n 
A 1 3   LYS 3   5   5   LYS LYS A . n 
A 1 4   MET 4   6   6   MET MET A . n 
A 1 5   ALA 5   7   7   ALA ALA A . n 
A 1 6   PHE 6   8   8   PHE PHE A . n 
A 1 7   PRO 7   9   9   PRO PRO A . n 
A 1 8   SER 8   10  10  SER SER A . n 
A 1 9   GLY 9   11  11  GLY GLY A . n 
A 1 10  LYS 10  12  12  LYS LYS A . n 
A 1 11  VAL 11  13  13  VAL VAL A . n 
A 1 12  GLU 12  14  14  GLU GLU A . n 
A 1 13  GLY 13  15  15  GLY GLY A . n 
A 1 14  CYS 14  16  16  CYS CYS A . n 
A 1 15  MET 15  17  17  MET MET A . n 
A 1 16  VAL 16  18  18  VAL VAL A . n 
A 1 17  GLN 17  19  19  GLN GLN A . n 
A 1 18  VAL 18  20  20  VAL VAL A . n 
A 1 19  THR 19  21  21  THR THR A . n 
A 1 20  CYS 20  22  22  CYS CYS A . n 
A 1 21  GLY 21  23  23  GLY GLY A . n 
A 1 22  THR 22  24  24  THR THR A . n 
A 1 23  THR 23  25  25  THR THR A . n 
A 1 24  THR 24  26  26  THR THR A . n 
A 1 25  LEU 25  27  27  LEU LEU A . n 
A 1 26  ASN 26  28  28  ASN ASN A . n 
A 1 27  GLY 27  29  29  GLY GLY A . n 
A 1 28  LEU 28  30  30  LEU LEU A . n 
A 1 29  TRP 29  31  31  TRP TRP A . n 
A 1 30  LEU 30  32  32  LEU LEU A . n 
A 1 31  ASP 31  33  33  ASP ASP A . n 
A 1 32  ASP 32  34  34  ASP ASP A . n 
A 1 33  VAL 33  35  35  VAL VAL A . n 
A 1 34  VAL 34  36  36  VAL VAL A . n 
A 1 35  TYR 35  37  37  TYR TYR A . n 
A 1 36  CYS 36  38  38  CYS CYS A . n 
A 1 37  PRO 37  39  39  PRO PRO A . n 
A 1 38  ARG 38  40  40  ARG ARG A . n 
A 1 39  HIS 39  41  41  HIS HIS A . n 
A 1 40  VAL 40  42  42  VAL VAL A . n 
A 1 41  ILE 41  43  43  ILE ILE A . n 
A 1 42  CYS 42  44  44  CYS CYS A . n 
A 1 43  THR 43  45  45  THR THR A . n 
A 1 44  SER 44  46  46  SER SER A . n 
A 1 45  GLU 45  47  47  GLU GLU A . n 
A 1 46  ASP 46  48  48  ASP ASP A . n 
A 1 47  ILE 47  49  49  ILE ILE A . n 
A 1 48  LEU 48  50  50  LEU LEU A . n 
A 1 49  ASN 49  51  51  ASN ASN A . n 
A 1 50  PRO 50  52  52  PRO PRO A . n 
A 1 51  ASN 51  53  53  ASN ASN A . n 
A 1 52  TYR 52  54  54  TYR TYR A . n 
A 1 53  GLU 53  55  55  GLU GLU A . n 
A 1 54  ASP 54  56  56  ASP ASP A . n 
A 1 55  LEU 55  57  57  LEU LEU A . n 
A 1 56  LEU 56  58  58  LEU LEU A . n 
A 1 57  ILE 57  59  59  ILE ILE A . n 
A 1 58  ARG 58  60  60  ARG ARG A . n 
A 1 59  LYS 59  61  61  LYS LYS A . n 
A 1 60  SER 60  62  62  SER SER A . n 
A 1 61  ASN 61  63  63  ASN ASN A . n 
A 1 62  HIS 62  64  64  HIS HIS A . n 
A 1 63  ASN 63  65  65  ASN ASN A . n 
A 1 64  PHE 64  66  66  PHE PHE A . n 
A 1 65  LEU 65  67  67  LEU LEU A . n 
A 1 66  VAL 66  68  68  VAL VAL A . n 
A 1 67  GLN 67  69  69  GLN GLN A . n 
A 1 68  ALA 68  70  70  ALA ALA A . n 
A 1 69  GLY 69  71  71  GLY GLY A . n 
A 1 70  ASN 70  72  72  ASN ASN A . n 
A 1 71  VAL 71  73  73  VAL VAL A . n 
A 1 72  GLN 72  74  74  GLN GLN A . n 
A 1 73  LEU 73  75  75  LEU LEU A . n 
A 1 74  ARG 74  76  76  ARG ARG A . n 
A 1 75  VAL 75  77  77  VAL VAL A . n 
A 1 76  ILE 76  78  78  ILE ILE A . n 
A 1 77  GLY 77  79  79  GLY GLY A . n 
A 1 78  HIS 78  80  80  HIS HIS A . n 
A 1 79  SER 79  81  81  SER SER A . n 
A 1 80  MET 80  82  82  MET MET A . n 
A 1 81  GLN 81  83  83  GLN GLN A . n 
A 1 82  ASN 82  84  84  ASN ASN A . n 
A 1 83  CYS 83  85  85  CYS CYS A . n 
A 1 84  VAL 84  86  86  VAL VAL A . n 
A 1 85  LEU 85  87  87  LEU LEU A . n 
A 1 86  LYS 86  88  88  LYS LYS A . n 
A 1 87  LEU 87  89  89  LEU LEU A . n 
A 1 88  LYS 88  90  90  LYS LYS A . n 
A 1 89  VAL 89  91  91  VAL VAL A . n 
A 1 90  ASP 90  92  92  ASP ASP A . n 
A 1 91  THR 91  93  93  THR THR A . n 
A 1 92  ALA 92  94  94  ALA ALA A . n 
A 1 93  ASN 93  95  95  ASN ASN A . n 
A 1 94  PRO 94  96  96  PRO PRO A . n 
A 1 95  LYS 95  97  97  LYS LYS A . n 
A 1 96  THR 96  98  98  THR THR A . n 
A 1 97  PRO 97  99  99  PRO PRO A . n 
A 1 98  LYS 98  100 100 LYS LYS A . n 
A 1 99  TYR 99  101 101 TYR TYR A . n 
A 1 100 LYS 100 102 102 LYS LYS A . n 
A 1 101 PHE 101 103 103 PHE PHE A . n 
A 1 102 VAL 102 104 104 VAL VAL A . n 
A 1 103 ARG 103 105 105 ARG ARG A . n 
A 1 104 ILE 104 106 106 ILE ILE A . n 
A 1 105 GLN 105 107 107 GLN GLN A . n 
A 1 106 PRO 106 108 108 PRO PRO A . n 
A 1 107 GLY 107 109 109 GLY GLY A . n 
A 1 108 GLN 108 110 110 GLN GLN A . n 
A 1 109 THR 109 111 111 THR THR A . n 
A 1 110 PHE 110 112 112 PHE PHE A . n 
A 1 111 SER 111 113 113 SER SER A . n 
A 1 112 VAL 112 114 114 VAL VAL A . n 
A 1 113 LEU 113 115 115 LEU LEU A . n 
A 1 114 ALA 114 116 116 ALA ALA A . n 
A 1 115 CYS 115 117 117 CYS CYS A . n 
A 1 116 TYR 116 118 118 TYR TYR A . n 
A 1 117 ASN 117 119 119 ASN ASN A . n 
A 1 118 GLY 118 120 120 GLY GLY A . n 
A 1 119 SER 119 121 121 SER SER A . n 
A 1 120 PRO 120 122 122 PRO PRO A . n 
A 1 121 SER 121 123 123 SER SER A . n 
A 1 122 GLY 122 124 124 GLY GLY A . n 
A 1 123 VAL 123 125 125 VAL VAL A . n 
A 1 124 TYR 124 126 126 TYR TYR A . n 
A 1 125 GLN 125 127 127 GLN GLN A . n 
A 1 126 CYS 126 128 128 CYS CYS A . n 
A 1 127 ALA 127 129 129 ALA ALA A . n 
A 1 128 MET 128 130 130 MET MET A . n 
A 1 129 ARG 129 131 131 ARG ARG A . n 
A 1 130 PRO 130 132 132 PRO PRO A . n 
A 1 131 ASN 131 133 133 ASN ASN A . n 
A 1 132 PHE 132 134 134 PHE PHE A . n 
A 1 133 THR 133 135 135 THR THR A . n 
A 1 134 ILE 134 136 136 ILE ILE A . n 
A 1 135 LYS 135 137 137 LYS LYS A . n 
A 1 136 GLY 136 138 138 GLY GLY A . n 
A 1 137 SER 137 139 139 SER SER A . n 
A 1 138 PHE 138 140 140 PHE PHE A . n 
A 1 139 LEU 139 141 141 LEU LEU A . n 
A 1 140 ASN 140 142 142 ASN ASN A . n 
A 1 141 GLY 141 143 143 GLY GLY A . n 
A 1 142 SER 142 144 144 SER SER A . n 
A 1 143 CYS 143 145 145 CYS CYS A . n 
A 1 144 GLY 144 146 146 GLY GLY A . n 
A 1 145 SER 145 147 147 SER SER A . n 
A 1 146 VAL 146 148 148 VAL VAL A . n 
A 1 147 GLY 147 149 149 GLY GLY A . n 
A 1 148 PHE 148 150 150 PHE PHE A . n 
A 1 149 ASN 149 151 151 ASN ASN A . n 
A 1 150 ILE 150 152 152 ILE ILE A . n 
A 1 151 ASP 151 153 153 ASP ASP A . n 
A 1 152 TYR 152 154 154 TYR TYR A . n 
A 1 153 ASP 153 155 155 ASP ASP A . n 
A 1 154 CYS 154 156 156 CYS CYS A . n 
A 1 155 VAL 155 157 157 VAL VAL A . n 
A 1 156 SER 156 158 158 SER SER A . n 
A 1 157 PHE 157 159 159 PHE PHE A . n 
A 1 158 CYS 158 160 160 CYS CYS A . n 
A 1 159 TYR 159 161 161 TYR TYR A . n 
A 1 160 MET 160 162 162 MET MET A . n 
A 1 161 HIS 161 163 163 HIS HIS A . n 
A 1 162 HIS 162 164 164 HIS HIS A . n 
A 1 163 MET 163 165 165 MET MET A . n 
A 1 164 GLU 164 166 166 GLU GLU A . n 
A 1 165 LEU 165 167 167 LEU LEU A . n 
A 1 166 PRO 166 168 168 PRO PRO A . n 
A 1 167 THR 167 169 169 THR THR A . n 
A 1 168 GLY 168 170 170 GLY GLY A . n 
A 1 169 VAL 169 171 171 VAL VAL A . n 
A 1 170 HIS 170 172 172 HIS HIS A . n 
A 1 171 ALA 171 173 173 ALA ALA A . n 
A 1 172 GLY 172 174 174 GLY GLY A . n 
A 1 173 THR 173 175 175 THR THR A . n 
A 1 174 ASP 174 176 176 ASP ASP A . n 
A 1 175 LEU 175 177 177 LEU LEU A . n 
A 1 176 GLU 176 178 178 GLU GLU A . n 
A 1 177 GLY 177 179 179 GLY GLY A . n 
A 1 178 ASN 178 180 180 ASN ASN A . n 
A 1 179 PHE 179 181 181 PHE PHE A . n 
A 1 180 TYR 180 182 182 TYR TYR A . n 
A 1 181 GLY 181 183 183 GLY GLY A . n 
A 1 182 PRO 182 184 184 PRO PRO A . n 
A 1 183 PHE 183 185 185 PHE PHE A . n 
A 1 184 VAL 184 186 186 VAL VAL A . n 
A 1 185 ASP 185 187 187 ASP ASP A . n 
A 1 186 ARG 186 188 188 ARG ARG A . n 
A 1 187 GLN 187 189 189 GLN GLN A . n 
A 1 188 THR 188 190 190 THR THR A . n 
A 1 189 ALA 189 191 191 ALA ALA A . n 
A 1 190 GLN 190 192 192 GLN GLN A . n 
A 1 191 ALA 191 193 193 ALA ALA A . n 
A 1 192 ALA 192 194 194 ALA ALA A . n 
A 1 193 GLY 193 195 195 GLY GLY A . n 
A 1 194 THR 194 196 196 THR THR A . n 
A 1 195 ASP 195 197 197 ASP ASP A . n 
A 1 196 THR 196 198 198 THR THR A . n 
A 1 197 THR 197 199 199 THR THR A . n 
A 1 198 ILE 198 200 200 ILE ILE A . n 
A 1 199 THR 199 201 201 THR THR A . n 
A 1 200 VAL 200 202 202 VAL VAL A . n 
A 1 201 ASN 201 203 203 ASN ASN A . n 
A 1 202 VAL 202 204 204 VAL VAL A . n 
A 1 203 LEU 203 205 205 LEU LEU A . n 
A 1 204 ALA 204 206 206 ALA ALA A . n 
A 1 205 TRP 205 207 207 TRP TRP A . n 
A 1 206 LEU 206 208 208 LEU LEU A . n 
A 1 207 TYR 207 209 209 TYR TYR A . n 
A 1 208 ALA 208 210 210 ALA ALA A . n 
A 1 209 ALA 209 211 211 ALA ALA A . n 
A 1 210 VAL 210 212 212 VAL VAL A . n 
A 1 211 ILE 211 213 213 ILE ILE A . n 
A 1 212 ASN 212 214 214 ASN ASN A . n 
A 1 213 GLY 213 215 215 GLY GLY A . n 
A 1 214 ASP 214 216 216 ASP ASP A . n 
A 1 215 ARG 215 217 217 ARG ARG A . n 
A 1 216 TRP 216 218 218 TRP TRP A . n 
A 1 217 PHE 217 219 219 PHE PHE A . n 
A 1 218 LEU 218 220 220 LEU LEU A . n 
A 1 219 ASN 219 221 221 ASN ASN A . n 
A 1 220 ARG 220 222 222 ARG ARG A . n 
A 1 221 PHE 221 223 223 PHE PHE A . n 
A 1 222 THR 222 224 224 THR THR A . n 
A 1 223 THR 223 225 225 THR THR A . n 
A 1 224 THR 224 226 226 THR THR A . n 
A 1 225 LEU 225 227 227 LEU LEU A . n 
A 1 226 ASN 226 228 228 ASN ASN A . n 
A 1 227 ASP 227 229 229 ASP ASP A . n 
A 1 228 PHE 228 230 230 PHE PHE A . n 
A 1 229 ASN 229 231 231 ASN ASN A . n 
A 1 230 LEU 230 232 232 LEU LEU A . n 
A 1 231 VAL 231 233 233 VAL VAL A . n 
A 1 232 ALA 232 234 234 ALA ALA A . n 
A 1 233 MET 233 235 235 MET MET A . n 
A 1 234 LYS 234 236 236 LYS LYS A . n 
A 1 235 TYR 235 237 237 TYR TYR A . n 
A 1 236 ASN 236 238 238 ASN ASN A . n 
A 1 237 TYR 237 239 239 TYR TYR A . n 
A 1 238 GLU 238 240 240 GLU GLU A . n 
A 1 239 PRO 239 241 241 PRO PRO A . n 
A 1 240 LEU 240 242 242 LEU LEU A . n 
A 1 241 THR 241 243 243 THR THR A . n 
A 1 242 GLN 242 244 244 GLN GLN A . n 
A 1 243 ASP 243 245 245 ASP ASP A . n 
A 1 244 HIS 244 246 246 HIS HIS A . n 
A 1 245 VAL 245 247 247 VAL VAL A . n 
A 1 246 ASP 246 248 248 ASP ASP A . n 
A 1 247 ILE 247 249 249 ILE ILE A . n 
A 1 248 LEU 248 250 250 LEU LEU A . n 
A 1 249 GLY 249 251 251 GLY GLY A . n 
A 1 250 PRO 250 252 252 PRO PRO A . n 
A 1 251 LEU 251 253 253 LEU LEU A . n 
A 1 252 SER 252 254 254 SER SER A . n 
A 1 253 ALA 253 255 255 ALA ALA A . n 
A 1 254 GLN 254 256 256 GLN GLN A . n 
A 1 255 THR 255 257 257 THR THR A . n 
A 1 256 GLY 256 258 258 GLY GLY A . n 
A 1 257 ILE 257 259 259 ILE ILE A . n 
A 1 258 ALA 258 260 260 ALA ALA A . n 
A 1 259 VAL 259 261 261 VAL VAL A . n 
A 1 260 LEU 260 262 262 LEU LEU A . n 
A 1 261 ASP 261 263 263 ASP ASP A . n 
A 1 262 MET 262 264 264 MET MET A . n 
A 1 263 CYS 263 265 265 CYS CYS A . n 
A 1 264 ALA 264 266 266 ALA ALA A . n 
A 1 265 SER 265 267 267 SER SER A . n 
A 1 266 LEU 266 268 268 LEU LEU A . n 
A 1 267 LYS 267 269 269 LYS LYS A . n 
A 1 268 GLU 268 270 270 GLU GLU A . n 
A 1 269 LEU 269 271 271 LEU LEU A . n 
A 1 270 LEU 270 272 272 LEU LEU A . n 
A 1 271 GLN 271 273 273 GLN GLN A . n 
A 1 272 ASN 272 274 274 ASN ASN A . n 
A 1 273 GLY 273 275 275 GLY GLY A . n 
A 1 274 MET 274 276 276 MET MET A . n 
A 1 275 ASN 275 277 277 ASN ASN A . n 
A 1 276 GLY 276 278 278 GLY GLY A . n 
A 1 277 ARG 277 279 279 ARG ARG A . n 
A 1 278 THR 278 280 280 THR THR A . n 
A 1 279 ILE 279 281 281 ILE ILE A . n 
A 1 280 LEU 280 282 282 LEU LEU A . n 
A 1 281 GLY 281 283 283 GLY GLY A . n 
A 1 282 SER 282 284 284 SER SER A . n 
A 1 283 ALA 283 285 285 ALA ALA A . n 
A 1 284 LEU 284 286 286 LEU LEU A . n 
A 1 285 LEU 285 287 287 LEU LEU A . n 
A 1 286 GLU 286 288 288 GLU GLU A . n 
A 1 287 ASP 287 289 289 ASP ASP A . n 
A 1 288 GLU 288 290 290 GLU GLU A . n 
A 1 289 PHE 289 291 291 PHE PHE A . n 
A 1 290 THR 290 292 292 THR THR A . n 
A 1 291 PRO 291 293 293 PRO PRO A . n 
A 1 292 PHE 292 294 294 PHE PHE A . n 
A 1 293 ASP 293 295 295 ASP ASP A . n 
A 1 294 VAL 294 296 296 VAL VAL A . n 
A 1 295 VAL 295 297 297 VAL VAL A . n 
A 1 296 ARG 296 298 298 ARG ARG A . n 
A 1 297 GLN 297 299 299 GLN GLN A . n 
A 1 298 CYS 298 300 300 CYS CYS A . n 
A 1 299 SER 299 301 301 SER SER A . n 
A 1 300 GLY 300 302 302 GLY GLY A . n 
A 1 301 VAL 301 303 303 VAL VAL A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X77 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X77 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 X77 1  401 1  X77 LIG A . 
C 3 HOH 1  501 6  HOH HOH A . 
C 3 HOH 2  502 13 HOH HOH A . 
C 3 HOH 3  503 9  HOH HOH A . 
C 3 HOH 4  504 12 HOH HOH A . 
C 3 HOH 5  505 11 HOH HOH A . 
C 3 HOH 6  506 3  HOH HOH A . 
C 3 HOH 7  507 14 HOH HOH A . 
C 3 HOH 8  508 7  HOH HOH A . 
C 3 HOH 9  509 18 HOH HOH A . 
C 3 HOH 10 510 21 HOH HOH A . 
C 3 HOH 11 511 15 HOH HOH A . 
C 3 HOH 12 512 4  HOH HOH A . 
C 3 HOH 13 513 10 HOH HOH A . 
C 3 HOH 14 514 20 HOH HOH A . 
C 3 HOH 15 515 16 HOH HOH A . 
C 3 HOH 16 516 8  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.12_2829 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.082 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YKP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     114.286 
_cell.length_a_esd                 ? 
_cell.length_b                     54.253 
_cell.length_b_esd                 ? 
_cell.length_c                     45.702 
_cell.length_c_esd                 ? 
_cell.volume                       278084.828 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YKP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YKP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.09 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.11 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.12M-0.21M Na2SO4, 20%-24% PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          45.9772752727 
_reflns.entry_id                                       8YKP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.40 
_reflns.d_resolution_low                               30.78 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10203 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           93.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.117 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.40 
_reflns_shell.d_res_low                                     2.53 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1570 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.986 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               51.0062587071 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YKP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.40 
_refine.ls_d_res_low                             30.78 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10191 
_refine.ls_number_reflns_R_free                  495 
_refine.ls_number_reflns_R_work                  9696 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    93.5211526108 
_refine.ls_percent_reflns_R_free                 4.85722696497 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.192122539225 
_refine.ls_R_factor_R_free                       0.262690517125 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.188567621547 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35473497857 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.5326058796 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.324453030048 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.40 
_refine_hist.d_res_low                        30.78 
_refine_hist.number_atoms_solvent             16 
_refine_hist.number_atoms_total               2380 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2330 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00842928832219 ? 2419 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.06802830561    ? 3291 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0546399392044  ? 369  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00621778458249 ? 426  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 10.4716557591    ? 1410 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.40   2.6401 . . 137 2548 99.040944301  . . . . 0.254047216933 . . . . . . . . . . . 0.346633733425 
'X-RAY DIFFRACTION' 2.6401 3.0218 . . 106 2357 90.952732644  . . . . 0.241670105761 . . . . . . . . . . . 0.319380512549 
'X-RAY DIFFRACTION' 3.0218 3.8061 . . 138 2279 89.3200295639 . . . . 0.202878857212 . . . . . . . . . . . 0.300373151921 
'X-RAY DIFFRACTION' 3.8061 30.78  . . 114 2512 94.733044733  . . . . 0.154208400002 . . . . . . . . . . . 0.205246901552 
# 
_struct.entry_id                     8YKP 
_struct.title                        'Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with X77' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YKP 
_struct_keywords.text            'VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGV
;
_struct_ref.pdbx_align_begin           3266 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YKP 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 301 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC1 
_struct_ref_seq.db_align_beg                  3266 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3566 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       3 
_struct_ref_seq.pdbx_auth_seq_align_end       303 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8YKP 
_struct_ref_seq_dif.mon_id                       ILE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      47 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTC1 
_struct_ref_seq_dif.db_mon_id                    MET 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3312 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            49 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2250  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  25770 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 8   ? GLY A 13  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 39  ? CYS A 42  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 51  ? ARG A 58  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4  AA4 SER A 60  ? HIS A 62  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P5  AA5 ILE A 198 ? ASN A 212 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 224 ? MET A 233 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P7  AA7 LYS A 234 ? ASN A 236 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P8  AA8 THR A 241 ? LEU A 248 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 248 ? GLY A 256 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 258 ? GLY A 273 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 290 ? GLY A 300 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 71  ? LEU A 73  ? VAL A 73  LEU A 75  
AA1 2 PHE A 64  ? ALA A 68  ? PHE A 66  ALA A 70  
AA1 3 MET A 15  ? CYS A 20  ? MET A 17  CYS A 22  
AA1 4 THR A 23  ? LEU A 30  ? THR A 25  LEU A 32  
AA1 5 VAL A 33  ? PRO A 37  ? VAL A 35  PRO A 39  
AA1 6 VAL A 84  ? VAL A 89  ? VAL A 86  VAL A 91  
AA1 7 VAL A 75  ? GLN A 81  ? VAL A 77  GLN A 83  
AA2 1 LYS A 98  ? PHE A 101 ? LYS A 100 PHE A 103 
AA2 2 CYS A 154 ? LEU A 165 ? CYS A 156 LEU A 167 
AA2 3 VAL A 146 ? ASP A 151 ? VAL A 148 ASP A 153 
AA2 4 THR A 109 ? TYR A 116 ? THR A 111 TYR A 118 
AA2 5 SER A 119 ? ALA A 127 ? SER A 121 ALA A 129 
AA3 1 LYS A 98  ? PHE A 101 ? LYS A 100 PHE A 103 
AA3 2 CYS A 154 ? LEU A 165 ? CYS A 156 LEU A 167 
AA3 3 VAL A 169 ? THR A 173 ? VAL A 171 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 73  ? O LEU A 75  N VAL A 66  ? N VAL A 68  
AA1 2 3 O LEU A 65  ? O LEU A 67  N THR A 19  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 20  O LEU A 25  ? O LEU A 27  
AA1 4 5 N LEU A 28  ? N LEU A 30  O TYR A 35  ? O TYR A 37  
AA1 5 6 N CYS A 36  ? N CYS A 38  O LEU A 85  ? O LEU A 87  
AA1 6 7 O VAL A 84  ? O VAL A 86  N GLN A 81  ? N GLN A 83  
AA2 1 2 N LYS A 100 ? N LYS A 102 O PHE A 157 ? O PHE A 159 
AA2 2 3 O SER A 156 ? O SER A 158 N ASN A 149 ? N ASN A 151 
AA2 3 4 O PHE A 148 ? O PHE A 150 N SER A 111 ? N SER A 113 
AA2 4 5 N ALA A 114 ? N ALA A 116 O SER A 121 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 102 O PHE A 157 ? O PHE A 159 
AA3 2 3 N LEU A 165 ? N LEU A 167 O VAL A 169 ? O VAL A 171 
# 
_pdbx_entry_details.entry_id                   8YKP 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD2 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    197 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    501 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.03 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CB 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            CYS 
_pdbx_validate_rmsd_bond.auth_seq_id_1             128 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            SG 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            CYS 
_pdbx_validate_rmsd_bond.auth_seq_id_2             128 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.710 
_pdbx_validate_rmsd_bond.bond_target_value         1.812 
_pdbx_validate_rmsd_bond.bond_deviation            -0.102 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.016 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_1              155 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_2              155 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             OD1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_3              155 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                124.07 
_pdbx_validate_rmsd_angle.angle_target_value         118.30 
_pdbx_validate_rmsd_angle.angle_deviation            5.77 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.90 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ARG A 4   ? ? 172.80  146.52  
2  1 ASP A 33  ? ? 47.92   -121.40 
3  1 ASN A 51  ? ? -159.00 76.37   
4  1 ASN A 84  ? ? 49.68   -117.09 
5  1 TYR A 154 ? ? 14.81   102.94  
6  1 ASP A 155 ? ? 73.43   -6.41   
7  1 THR A 169 ? ? -69.30  0.97    
8  1 ASN A 214 ? ? -97.31  34.90   
9  1 THR A 224 ? ? -113.29 -166.57 
10 1 THR A 225 ? ? -171.95 -174.68 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ARG 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    222 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   PHE 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    223 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            -148.46 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
X77 C02  C N N 391 
X77 C04  C N R 392 
X77 C05  C N N 393 
X77 C07  C N N 394 
X77 C08  C N N 395 
X77 C09  C N N 396 
X77 C10  C N N 397 
X77 C11  C N N 398 
X77 C12  C N N 399 
X77 C14  C Y N 400 
X77 C15  C Y N 401 
X77 C16  C Y N 402 
X77 C17  C Y N 403 
X77 C19  C Y N 404 
X77 C20  C Y N 405 
X77 C21  C Y N 406 
X77 C22  C Y N 407 
X77 C23  C Y N 408 
X77 C24  C N N 409 
X77 C25  C N N 410 
X77 C26  C N N 411 
X77 C27  C N N 412 
X77 C28  C Y N 413 
X77 C29  C Y N 414 
X77 C30  C Y N 415 
X77 C31  C Y N 416 
X77 C33  C Y N 417 
X77 N03  N N N 418 
X77 N06  N N N 419 
X77 N18  N Y N 420 
X77 N32  N Y N 421 
X77 N34  N Y N 422 
X77 O01  O N N 423 
X77 O13  O N N 424 
X77 H041 H N N 425 
X77 H071 H N N 426 
X77 H081 H N N 427 
X77 H082 H N N 428 
X77 H091 H N N 429 
X77 H092 H N N 430 
X77 H101 H N N 431 
X77 H102 H N N 432 
X77 H112 H N N 433 
X77 H111 H N N 434 
X77 H121 H N N 435 
X77 H122 H N N 436 
X77 H151 H N N 437 
X77 H161 H N N 438 
X77 H171 H N N 439 
X77 H191 H N N 440 
X77 H211 H N N 441 
X77 H221 H N N 442 
X77 H251 H N N 443 
X77 H252 H N N 444 
X77 H253 H N N 445 
X77 H261 H N N 446 
X77 H263 H N N 447 
X77 H262 H N N 448 
X77 H272 H N N 449 
X77 H273 H N N 450 
X77 H271 H N N 451 
X77 H281 H N N 452 
X77 H291 H N N 453 
X77 H311 H N N 454 
X77 H331 H N N 455 
X77 H061 H N N 456 
X77 H1   H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
X77 C33 N32  sing Y N 376 
X77 C33 N34  doub Y N 377 
X77 N32 C31  sing Y N 378 
X77 N34 C30  sing Y N 379 
X77 C31 C30  doub Y N 380 
X77 C30 C02  sing N N 381 
X77 C27 C24  sing N N 382 
X77 C02 O01  doub N N 383 
X77 C02 N03  sing N N 384 
X77 C26 C24  sing N N 385 
X77 C28 C29  doub Y N 386 
X77 C28 C23  sing Y N 387 
X77 C24 C23  sing N N 388 
X77 C24 C25  sing N N 389 
X77 C29 C20  sing Y N 390 
X77 C23 C22  doub Y N 391 
X77 C20 N03  sing N N 392 
X77 C20 C21  doub Y N 393 
X77 C22 C21  sing Y N 394 
X77 N03 C04  sing N N 395 
X77 C19 N18  doub Y N 396 
X77 C19 C14  sing Y N 397 
X77 C04 C14  sing N N 398 
X77 C04 C05  sing N N 399 
X77 N18 C17  sing Y N 400 
X77 C14 C15  doub Y N 401 
X77 O13 C05  doub N N 402 
X77 C17 C16  doub Y N 403 
X77 C05 N06  sing N N 404 
X77 C15 C16  sing Y N 405 
X77 N06 C07  sing N N 406 
X77 C12 C07  sing N N 407 
X77 C12 C11  sing N N 408 
X77 C07 C08  sing N N 409 
X77 C11 C10  sing N N 410 
X77 C08 C09  sing N N 411 
X77 C10 C09  sing N N 412 
X77 C04 H041 sing N N 413 
X77 C07 H071 sing N N 414 
X77 C08 H081 sing N N 415 
X77 C08 H082 sing N N 416 
X77 C09 H091 sing N N 417 
X77 C09 H092 sing N N 418 
X77 C10 H101 sing N N 419 
X77 C10 H102 sing N N 420 
X77 C11 H112 sing N N 421 
X77 C11 H111 sing N N 422 
X77 C12 H121 sing N N 423 
X77 C12 H122 sing N N 424 
X77 C15 H151 sing N N 425 
X77 C16 H161 sing N N 426 
X77 C17 H171 sing N N 427 
X77 C19 H191 sing N N 428 
X77 C21 H211 sing N N 429 
X77 C22 H221 sing N N 430 
X77 C25 H251 sing N N 431 
X77 C25 H252 sing N N 432 
X77 C25 H253 sing N N 433 
X77 C26 H261 sing N N 434 
X77 C26 H263 sing N N 435 
X77 C26 H262 sing N N 436 
X77 C27 H272 sing N N 437 
X77 C27 H273 sing N N 438 
X77 C27 H271 sing N N 439 
X77 C28 H281 sing N N 440 
X77 C29 H291 sing N N 441 
X77 C31 H311 sing N N 442 
X77 C33 H331 sing N N 443 
X77 N06 H061 sing N N 444 
X77 N32 H1   sing N N 445 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7C2Q 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YKP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008750 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001714 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018432 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022297 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 1   ? -0.91442 6.96147   -10.68747 1.000 60.49370 ? 3   PHE A N   1 
ATOM   2    C CA  . PHE A 1 1   ? 0.28348  6.82287   -9.85170  1.000 55.46740 ? 3   PHE A CA  1 
ATOM   3    C C   . PHE A 1 1   ? -0.06611 6.90540   -8.37570  1.000 55.65315 ? 3   PHE A C   1 
ATOM   4    O O   . PHE A 1 1   ? -1.06193 7.54093   -8.01993  1.000 62.42382 ? 3   PHE A O   1 
ATOM   5    C CB  . PHE A 1 1   ? 1.32486  7.88698   -10.19483 1.000 48.43230 ? 3   PHE A CB  1 
ATOM   6    C CG  . PHE A 1 1   ? 2.71046  7.53004   -9.75422  1.000 47.69696 ? 3   PHE A CG  1 
ATOM   7    C CD1 . PHE A 1 1   ? 3.52092  6.72164   -10.54503 1.000 50.27317 ? 3   PHE A CD1 1 
ATOM   8    C CD2 . PHE A 1 1   ? 3.20208  7.99091   -8.54579  1.000 49.51432 ? 3   PHE A CD2 1 
ATOM   9    C CE1 . PHE A 1 1   ? 4.80421  6.37951   -10.13303 1.000 51.52191 ? 3   PHE A CE1 1 
ATOM   10   C CE2 . PHE A 1 1   ? 4.48298  7.66059   -8.11828  1.000 49.59870 ? 3   PHE A CE2 1 
ATOM   11   C CZ  . PHE A 1 1   ? 5.28867  6.84967   -8.91005  1.000 51.00850 ? 3   PHE A CZ  1 
ATOM   12   N N   . ARG A 1 2   ? 0.79131  6.31328   -7.52829  1.000 51.13340 ? 4   ARG A N   1 
ATOM   13   C CA  . ARG A 1 2   ? 0.40019  5.89713   -6.18407  1.000 50.51666 ? 4   ARG A CA  1 
ATOM   14   C C   . ARG A 1 2   ? 1.47172  5.08587   -5.43982  1.000 46.46593 ? 4   ARG A C   1 
ATOM   15   O O   . ARG A 1 2   ? 2.19805  4.29794   -6.05344  1.000 47.09178 ? 4   ARG A O   1 
ATOM   16   C CB  . ARG A 1 2   ? -0.86575 5.06431   -6.31267  1.000 51.36597 ? 4   ARG A CB  1 
ATOM   17   C CG  . ARG A 1 2   ? -1.58349 4.85170   -5.06582  1.000 50.75881 ? 4   ARG A CG  1 
ATOM   18   C CD  . ARG A 1 2   ? -2.77509 4.01637   -5.36169  1.000 46.81819 ? 4   ARG A CD  1 
ATOM   19   N NE  . ARG A 1 2   ? -3.96177 4.62724   -4.78837  1.000 51.90225 ? 4   ARG A NE  1 
ATOM   20   C CZ  . ARG A 1 2   ? -4.93575 5.15052   -5.50835  1.000 49.21325 ? 4   ARG A CZ  1 
ATOM   21   N NH1 . ARG A 1 2   ? -4.85169 5.10774   -6.83444  1.000 54.63941 ? 4   ARG A NH1 1 
ATOM   22   N NH2 . ARG A 1 2   ? -5.98984 5.70590   -4.90984  1.000 45.65570 ? 4   ARG A NH2 1 
ATOM   23   N N   . LYS A 1 3   ? 1.56322  5.22798   -4.11820  1.000 41.77708 ? 5   LYS A N   1 
ATOM   24   C CA  . LYS A 1 3   ? 2.44140  4.35126   -3.33849  1.000 44.86088 ? 5   LYS A CA  1 
ATOM   25   C C   . LYS A 1 3   ? 1.94242  2.89679   -3.38280  1.000 46.77390 ? 5   LYS A C   1 
ATOM   26   O O   . LYS A 1 3   ? 0.84539  2.57673   -2.90434  1.000 46.03951 ? 5   LYS A O   1 
ATOM   27   C CB  . LYS A 1 3   ? 2.55954  4.85024   -1.90056  1.000 37.43954 ? 5   LYS A CB  1 
ATOM   28   C CG  . LYS A 1 3   ? 3.94561  5.41620   -1.57738  1.000 44.43163 ? 5   LYS A CG  1 
ATOM   29   C CD  . LYS A 1 3   ? 3.91633  6.28820   -0.32463  1.000 50.57916 ? 5   LYS A CD  1 
ATOM   30   C CE  . LYS A 1 3   ? 5.28083  6.89808   -0.01352  1.000 55.04314 ? 5   LYS A CE  1 
ATOM   31   N NZ  . LYS A 1 3   ? 5.74129  7.80038   -1.11321  1.000 48.40376 ? 5   LYS A NZ  1 
ATOM   32   N N   . MET A 1 4   ? 2.76038  2.01799   -3.95273  1.000 39.55758 ? 6   MET A N   1 
ATOM   33   C CA  . MET A 1 4   ? 2.36831  0.66388   -4.30264  1.000 41.37424 ? 6   MET A CA  1 
ATOM   34   C C   . MET A 1 4   ? 3.33602  -0.31795  -3.66302  1.000 39.87831 ? 6   MET A C   1 
ATOM   35   O O   . MET A 1 4   ? 4.55131  -0.16155  -3.79385  1.000 40.25330 ? 6   MET A O   1 
ATOM   36   C CB  . MET A 1 4   ? 2.36869  0.49592   -5.82084  1.000 41.96165 ? 6   MET A CB  1 
ATOM   37   C CG  . MET A 1 4   ? 1.85042  -0.82082  -6.30243  1.000 43.37616 ? 6   MET A CG  1 
ATOM   38   S SD  . MET A 1 4   ? 1.21384  -0.68638  -7.99417  1.000 54.74401 ? 6   MET A SD  1 
ATOM   39   C CE  . MET A 1 4   ? 0.38660  0.90744   -7.91551  1.000 42.58815 ? 6   MET A CE  1 
ATOM   40   N N   . ALA A 1 5   ? 2.80109  -1.33052  -2.99485  1.000 35.76656 ? 7   ALA A N   1 
ATOM   41   C CA  . ALA A 1 5   ? 3.60155  -2.31020  -2.28122  1.000 41.05621 ? 7   ALA A CA  1 
ATOM   42   C C   . ALA A 1 5   ? 3.62488  -3.63990  -3.01829  1.000 38.81785 ? 7   ALA A C   1 
ATOM   43   O O   . ALA A 1 5   ? 2.75605  -3.93756  -3.83400  1.000 38.97833 ? 7   ALA A O   1 
ATOM   44   C CB  . ALA A 1 5   ? 3.07044  -2.52292  -0.86174  1.000 38.08691 ? 7   ALA A CB  1 
ATOM   45   N N   . PHE A 1 6   ? 4.63600  -4.44474  -2.70943  1.000 41.87231 ? 8   PHE A N   1 
ATOM   46   C CA  . PHE A 1 6   ? 4.71966  -5.77044  -3.28983  1.000 39.97835 ? 8   PHE A CA  1 
ATOM   47   C C   . PHE A 1 6   ? 3.62038  -6.66543  -2.73551  1.000 37.92456 ? 8   PHE A C   1 
ATOM   48   O O   . PHE A 1 6   ? 3.24825  -6.54876  -1.56285  1.000 34.45961 ? 8   PHE A O   1 
ATOM   49   C CB  . PHE A 1 6   ? 6.06759  -6.41336  -2.99642  1.000 40.98827 ? 8   PHE A CB  1 
ATOM   50   C CG  . PHE A 1 6   ? 7.21538  -5.75072  -3.68293  1.000 41.53885 ? 8   PHE A CG  1 
ATOM   51   C CD1 . PHE A 1 6   ? 7.40435  -5.90289  -5.05259  1.000 42.62490 ? 8   PHE A CD1 1 
ATOM   52   C CD2 . PHE A 1 6   ? 8.11545  -4.98410  -2.95984  1.000 41.75611 ? 8   PHE A CD2 1 
ATOM   53   C CE1 . PHE A 1 6   ? 8.47440  -5.29920  -5.69339  1.000 46.95356 ? 8   PHE A CE1 1 
ATOM   54   C CE2 . PHE A 1 6   ? 9.18003  -4.37167  -3.59182  1.000 45.65064 ? 8   PHE A CE2 1 
ATOM   55   C CZ  . PHE A 1 6   ? 9.36800  -4.53255  -4.96462  1.000 43.90597 ? 8   PHE A CZ  1 
ATOM   56   N N   . PRO A 1 7   ? 3.09967  -7.57624  -3.55771  1.000 37.13368 ? 9   PRO A N   1 
ATOM   57   C CA  . PRO A 1 7   ? 2.24859  -8.64317  -3.03451  1.000 42.46966 ? 9   PRO A CA  1 
ATOM   58   C C   . PRO A 1 7   ? 2.96786  -9.36353  -1.89994  1.000 41.21581 ? 9   PRO A C   1 
ATOM   59   O O   . PRO A 1 7   ? 4.16616  -9.65583  -1.98702  1.000 37.61971 ? 9   PRO A O   1 
ATOM   60   C CB  . PRO A 1 7   ? 2.04492  -9.55801  -4.25041  1.000 38.93231 ? 9   PRO A CB  1 
ATOM   61   C CG  . PRO A 1 7   ? 2.38529  -8.74826  -5.41297  1.000 35.40186 ? 9   PRO A CG  1 
ATOM   62   C CD  . PRO A 1 7   ? 3.42568  -7.78817  -4.97467  1.000 37.08834 ? 9   PRO A CD  1 
ATOM   63   N N   . SER A 1 8   ? 2.22479  -9.67459  -0.84281  1.000 38.72782 ? 10  SER A N   1 
ATOM   64   C CA  . SER A 1 8   ? 2.83317  -10.04585 0.42452   1.000 40.63541 ? 10  SER A CA  1 
ATOM   65   C C   . SER A 1 8   ? 2.68195  -11.51369 0.79202   1.000 41.95255 ? 10  SER A C   1 
ATOM   66   O O   . SER A 1 8   ? 3.10950  -11.89520 1.88221   1.000 43.44251 ? 10  SER A O   1 
ATOM   67   C CB  . SER A 1 8   ? 2.24647  -9.19011  1.54862   1.000 41.72853 ? 10  SER A CB  1 
ATOM   68   O OG  . SER A 1 8   ? 0.83948  -9.37759  1.65193   1.000 43.78662 ? 10  SER A OG  1 
ATOM   69   N N   . GLY A 1 9   ? 2.10175  -12.34633 -0.07686  1.000 42.72169 ? 11  GLY A N   1 
ATOM   70   C CA  . GLY A 1 9   ? 1.78098  -13.71173 0.31679   1.000 37.26645 ? 11  GLY A CA  1 
ATOM   71   C C   . GLY A 1 9   ? 3.00145  -14.53743 0.67207   1.000 39.75929 ? 11  GLY A C   1 
ATOM   72   O O   . GLY A 1 9   ? 3.00446  -15.27189 1.66892   1.000 41.05635 ? 11  GLY A O   1 
ATOM   73   N N   . LYS A 1 10  ? 4.05757  -14.42626 -0.12899  1.000 41.21937 ? 12  LYS A N   1 
ATOM   74   C CA  . LYS A 1 10  ? 5.28886  -15.14606 0.16441   1.000 39.60858 ? 12  LYS A CA  1 
ATOM   75   C C   . LYS A 1 10  ? 5.81872  -14.85547 1.55906   1.000 41.87755 ? 12  LYS A C   1 
ATOM   76   O O   . LYS A 1 10  ? 6.59981  -15.64996 2.08838   1.000 42.45463 ? 12  LYS A O   1 
ATOM   77   C CB  . LYS A 1 10  ? 6.36735  -14.78145 -0.85182  1.000 43.27590 ? 12  LYS A CB  1 
ATOM   78   C CG  . LYS A 1 10  ? 5.98632  -15.02132 -2.27396  1.000 39.73182 ? 12  LYS A CG  1 
ATOM   79   C CD  . LYS A 1 10  ? 7.18914  -14.89370 -3.17704  1.000 41.45309 ? 12  LYS A CD  1 
ATOM   80   C CE  . LYS A 1 10  ? 6.81960  -15.44272 -4.53539  1.000 52.63539 ? 12  LYS A CE  1 
ATOM   81   N NZ  . LYS A 1 10  ? 5.92158  -16.62664 -4.36218  1.000 46.36141 ? 12  LYS A NZ  1 
ATOM   82   N N   . VAL A 1 11  ? 5.43140  -13.73279 2.16001   1.000 40.82984 ? 13  VAL A N   1 
ATOM   83   C CA  . VAL A 1 11  ? 5.99409  -13.33086 3.43977   1.000 41.38521 ? 13  VAL A CA  1 
ATOM   84   C C   . VAL A 1 11  ? 5.00110  -13.62680 4.55631   1.000 41.22355 ? 13  VAL A C   1 
ATOM   85   O O   . VAL A 1 11  ? 5.39323  -13.87790 5.69979   1.000 41.20451 ? 13  VAL A O   1 
ATOM   86   C CB  . VAL A 1 11  ? 6.39161  -11.84932 3.38621   1.000 43.38925 ? 13  VAL A CB  1 
ATOM   87   C CG1 . VAL A 1 11  ? 7.00186  -11.39221 4.71663   1.000 38.21541 ? 13  VAL A CG1 1 
ATOM   88   C CG2 . VAL A 1 11  ? 7.35288  -11.64236 2.22045   1.000 37.95332 ? 13  VAL A CG2 1 
ATOM   89   N N   . GLU A 1 12  ? 3.70729  -13.62324 4.22536   1.000 41.45293 ? 14  GLU A N   1 
ATOM   90   C CA  . GLU A 1 12  ? 2.68652  -13.90430 5.23034   1.000 44.44642 ? 14  GLU A CA  1 
ATOM   91   C C   . GLU A 1 12  ? 2.82538  -15.31835 5.78421   1.000 47.32714 ? 14  GLU A C   1 
ATOM   92   O O   . GLU A 1 12  ? 2.59527  -15.54673 6.98285   1.000 46.43389 ? 14  GLU A O   1 
ATOM   93   C CB  . GLU A 1 12  ? 1.28602  -13.69555 4.63489   1.000 46.67483 ? 14  GLU A CB  1 
ATOM   94   C CG  . GLU A 1 12  ? 0.99499  -12.26260 4.16430   1.000 39.73172 ? 14  GLU A CG  1 
ATOM   95   C CD  . GLU A 1 12  ? -0.14703 -12.17427 3.16654   1.000 43.89996 ? 14  GLU A CD  1 
ATOM   96   O OE1 . GLU A 1 12  ? -1.24731 -12.69672 3.44721   1.000 48.99234 ? 14  GLU A OE1 1 
ATOM   97   O OE2 . GLU A 1 12  ? 0.04295  -11.56374 2.09194   1.000 48.68527 ? 14  GLU A OE2 1 
ATOM   98   N N   . GLY A 1 13  ? 3.21600  -16.27849 4.93684   1.000 47.94660 ? 15  GLY A N   1 
ATOM   99   C CA  . GLY A 1 13  ? 3.40508  -17.64885 5.38638   1.000 44.17609 ? 15  GLY A CA  1 
ATOM   100  C C   . GLY A 1 13  ? 4.59644  -17.85372 6.29346   1.000 44.25476 ? 15  GLY A C   1 
ATOM   101  O O   . GLY A 1 13  ? 4.78091  -18.95664 6.81515   1.000 48.40427 ? 15  GLY A O   1 
ATOM   102  N N   . CYS A 1 14  ? 5.40625  -16.81698 6.49216   1.000 40.05976 ? 16  CYS A N   1 
ATOM   103  C CA  . CYS A 1 14  ? 6.59576  -16.87299 7.32439   1.000 37.10710 ? 16  CYS A CA  1 
ATOM   104  C C   . CYS A 1 14  ? 6.42241  -16.20586 8.67953   1.000 39.19552 ? 16  CYS A C   1 
ATOM   105  O O   . CYS A 1 14  ? 7.33164  -16.28636 9.50501   1.000 44.12258 ? 16  CYS A O   1 
ATOM   106  C CB  . CYS A 1 14  ? 7.76735  -16.21478 6.59824   1.000 37.15734 ? 16  CYS A CB  1 
ATOM   107  S SG  . CYS A 1 14  ? 8.18426  -16.97572 5.01261   1.000 43.32856 ? 16  CYS A SG  1 
ATOM   108  N N   . MET A 1 15  ? 5.30198  -15.53981 8.93124   1.000 40.15932 ? 17  MET A N   1 
ATOM   109  C CA  . MET A 1 15  ? 5.13793  -14.78288 10.16282  1.000 43.15968 ? 17  MET A CA  1 
ATOM   110  C C   . MET A 1 15  ? 4.56371  -15.68263 11.24097  1.000 44.89454 ? 17  MET A C   1 
ATOM   111  O O   . MET A 1 15  ? 3.54711  -16.34887 11.02615  1.000 48.43304 ? 17  MET A O   1 
ATOM   112  C CB  . MET A 1 15  ? 4.22781  -13.56479 9.97042   1.000 43.86429 ? 17  MET A CB  1 
ATOM   113  C CG  . MET A 1 15  ? 4.76852  -12.51418 9.02970   1.000 43.10294 ? 17  MET A CG  1 
ATOM   114  S SD  . MET A 1 15  ? 6.51358  -12.11380 9.28635   1.000 42.30468 ? 17  MET A SD  1 
ATOM   115  C CE  . MET A 1 15  ? 6.42635  -11.25180 10.87035  1.000 45.00300 ? 17  MET A CE  1 
ATOM   116  N N   . VAL A 1 16  ? 5.21214  -15.67482 12.40325  1.000 45.25856 ? 18  VAL A N   1 
ATOM   117  C CA  . VAL A 1 16  ? 4.80688  -16.44304 13.56578  1.000 48.09688 ? 18  VAL A CA  1 
ATOM   118  C C   . VAL A 1 16  ? 4.80658  -15.52359 14.77736  1.000 48.29667 ? 18  VAL A C   1 
ATOM   119  O O   . VAL A 1 16  ? 5.32709  -14.40285 14.74395  1.000 45.98521 ? 18  VAL A O   1 
ATOM   120  C CB  . VAL A 1 16  ? 5.73704  -17.63875 13.81322  1.000 45.27683 ? 18  VAL A CB  1 
ATOM   121  C CG1 . VAL A 1 16  ? 5.71102  -18.56640 12.62557  1.000 46.36356 ? 18  VAL A CG1 1 
ATOM   122  C CG2 . VAL A 1 16  ? 7.12891  -17.13207 14.05961  1.000 39.76048 ? 18  VAL A CG2 1 
ATOM   123  N N   . GLN A 1 17  ? 4.21980  -16.02127 15.86217  1.000 50.15475 ? 19  GLN A N   1 
ATOM   124  C CA  . GLN A 1 17  ? 4.20381  -15.32263 17.14344  1.000 50.08744 ? 19  GLN A CA  1 
ATOM   125  C C   . GLN A 1 17  ? 5.29734  -15.89757 18.03054  1.000 50.88274 ? 19  GLN A C   1 
ATOM   126  O O   . GLN A 1 17  ? 5.44817  -17.11907 18.11963  1.000 49.22276 ? 19  GLN A O   1 
ATOM   127  C CB  . GLN A 1 17  ? 2.84639  -15.46769 17.82487  1.000 52.10714 ? 19  GLN A CB  1 
ATOM   128  C CG  . GLN A 1 17  ? 2.62172  -14.55374 19.01193  1.000 53.74038 ? 19  GLN A CG  1 
ATOM   129  C CD  . GLN A 1 17  ? 1.42104  -14.98840 19.85033  1.000 58.43685 ? 19  GLN A CD  1 
ATOM   130  O OE1 . GLN A 1 17  ? 1.20786  -16.18415 20.08058  1.000 64.66608 ? 19  GLN A OE1 1 
ATOM   131  N NE2 . GLN A 1 17  ? 0.63380  -14.01837 20.30889  1.000 58.25136 ? 19  GLN A NE2 1 
ATOM   132  N N   . VAL A 1 18  ? 6.06535  -15.02572 18.67039  1.000 48.89792 ? 20  VAL A N   1 
ATOM   133  C CA  . VAL A 1 18  ? 7.11633  -15.44409 19.58117  1.000 48.94587 ? 20  VAL A CA  1 
ATOM   134  C C   . VAL A 1 18  ? 6.82395  -14.82503 20.92825  1.000 52.07044 ? 20  VAL A C   1 
ATOM   135  O O   . VAL A 1 18  ? 6.67601  -13.59725 21.03615  1.000 53.12935 ? 20  VAL A O   1 
ATOM   136  C CB  . VAL A 1 18  ? 8.51033  -15.05361 19.07800  1.000 48.82704 ? 20  VAL A CB  1 
ATOM   137  C CG1 . VAL A 1 18  ? 9.56192  -15.46895 20.10624  1.000 45.37402 ? 20  VAL A CG1 1 
ATOM   138  C CG2 . VAL A 1 18  ? 8.77518  -15.73623 17.75909  1.000 47.72932 ? 20  VAL A CG2 1 
ATOM   139  N N   . THR A 1 19  ? 6.69768  -15.67019 21.94848  1.000 54.53667 ? 21  THR A N   1 
ATOM   140  C CA  . THR A 1 19  ? 6.43863  -15.21646 23.30363  1.000 57.54709 ? 21  THR A CA  1 
ATOM   141  C C   . THR A 1 19  ? 7.62957  -15.58655 24.18023  1.000 58.34836 ? 21  THR A C   1 
ATOM   142  O O   . THR A 1 19  ? 8.26951  -16.61905 23.96854  1.000 53.55138 ? 21  THR A O   1 
ATOM   143  C CB  . THR A 1 19  ? 5.13508  -15.81854 23.85738  1.000 60.62303 ? 21  THR A CB  1 
ATOM   144  O OG1 . THR A 1 19  ? 4.16832  -15.93822 22.80527  1.000 60.30992 ? 21  THR A OG1 1 
ATOM   145  C CG2 . THR A 1 19  ? 4.54431  -14.92500 24.93723  1.000 63.43100 ? 21  THR A CG2 1 
ATOM   146  N N   . CYS A 1 20  ? 7.94668  -14.72844 25.14561  1.000 58.91343 ? 22  CYS A N   1 
ATOM   147  C CA  . CYS A 1 20  ? 9.07640  -14.98795 26.03611  1.000 60.97399 ? 22  CYS A CA  1 
ATOM   148  C C   . CYS A 1 20  ? 8.78500  -14.28397 27.34619  1.000 57.68660 ? 22  CYS A C   1 
ATOM   149  O O   . CYS A 1 20  ? 8.84068  -13.05216 27.40920  1.000 60.51992 ? 22  CYS A O   1 
ATOM   150  C CB  . CYS A 1 20  ? 10.38822 -14.50294 25.43069  1.000 59.80455 ? 22  CYS A CB  1 
ATOM   151  S SG  . CYS A 1 20  ? 11.83006 -14.91022 26.39186  1.000 66.86163 ? 22  CYS A SG  1 
ATOM   152  N N   . GLY A 1 21  ? 8.49342  -15.06429 28.38270  1.000 63.44974 ? 23  GLY A N   1 
ATOM   153  C CA  . GLY A 1 21  ? 7.86338  -14.48598 29.55516  1.000 58.08688 ? 23  GLY A CA  1 
ATOM   154  C C   . GLY A 1 21  ? 6.47548  -14.03982 29.15701  1.000 57.63629 ? 23  GLY A C   1 
ATOM   155  O O   . GLY A 1 21  ? 5.74841  -14.75969 28.46261  1.000 63.86321 ? 23  GLY A O   1 
ATOM   156  N N   . THR A 1 22  ? 6.10296  -12.83082 29.56461  1.000 57.66777 ? 24  THR A N   1 
ATOM   157  C CA  . THR A 1 22  ? 4.84676  -12.22572 29.14855  1.000 59.12316 ? 24  THR A CA  1 
ATOM   158  C C   . THR A 1 22  ? 5.03040  -11.25937 27.99142  1.000 63.09910 ? 24  THR A C   1 
ATOM   159  O O   . THR A 1 22  ? 4.16420  -10.40382 27.76285  1.000 59.10352 ? 24  THR A O   1 
ATOM   160  C CB  . THR A 1 22  ? 4.20485  -11.47560 30.30731  1.000 59.01910 ? 24  THR A CB  1 
ATOM   161  O OG1 . THR A 1 22  ? 5.02440  -10.34292 30.62063  1.000 59.69308 ? 24  THR A OG1 1 
ATOM   162  C CG2 . THR A 1 22  ? 4.10594  -12.38231 31.52404  1.000 64.62360 ? 24  THR A CG2 1 
ATOM   163  N N   . THR A 1 23  ? 6.15364  -11.34274 27.28545  1.000 60.66437 ? 25  THR A N   1 
ATOM   164  C CA  . THR A 1 23  ? 6.40233  -10.49296 26.12984  1.000 60.88823 ? 25  THR A CA  1 
ATOM   165  C C   . THR A 1 23  ? 5.96956  -11.25299 24.88353  1.000 53.78009 ? 25  THR A C   1 
ATOM   166  O O   . THR A 1 23  ? 6.33511  -12.41750 24.71190  1.000 54.24378 ? 25  THR A O   1 
ATOM   167  C CB  . THR A 1 23  ? 7.87797  -10.09638 26.03619  1.000 58.58773 ? 25  THR A CB  1 
ATOM   168  O OG1 . THR A 1 23  ? 8.15819  -9.04809  26.97227  1.000 61.89619 ? 25  THR A OG1 1 
ATOM   169  C CG2 . THR A 1 23  ? 8.20244  -9.58446  24.64561  1.000 58.73875 ? 25  THR A CG2 1 
ATOM   170  N N   . THR A 1 24  ? 5.17759  -10.60262 24.03443  1.000 51.10519 ? 26  THR A N   1 
ATOM   171  C CA  . THR A 1 24  ? 4.73735  -11.17772 22.76736  1.000 55.86869 ? 26  THR A CA  1 
ATOM   172  C C   . THR A 1 24  ? 5.11588  -10.26760 21.59929  1.000 50.92453 ? 26  THR A C   1 
ATOM   173  O O   . THR A 1 24  ? 4.85853  -9.05370  21.63011  1.000 48.93419 ? 26  THR A O   1 
ATOM   174  C CB  . THR A 1 24  ? 3.22508  -11.42183 22.78371  1.000 54.23839 ? 26  THR A CB  1 
ATOM   175  O OG1 . THR A 1 24  ? 2.80239  -11.84743 21.48377  1.000 60.38661 ? 26  THR A OG1 1 
ATOM   176  C CG2 . THR A 1 24  ? 2.47414  -10.15097 23.17679  1.000 56.30425 ? 26  THR A CG2 1 
ATOM   177  N N   . LEU A 1 25  ? 5.72971  -10.85000 20.57296  1.000 47.16051 ? 27  LEU A N   1 
ATOM   178  C CA  . LEU A 1 25  ? 6.01781  -10.10389 19.35283  1.000 47.86047 ? 27  LEU A CA  1 
ATOM   179  C C   . LEU A 1 25  ? 6.16143  -11.08915 18.19822  1.000 46.44930 ? 27  LEU A C   1 
ATOM   180  O O   . LEU A 1 25  ? 6.00368  -12.30319 18.36789  1.000 50.88382 ? 27  LEU A O   1 
ATOM   181  C CB  . LEU A 1 25  ? 7.25622  -9.21670  19.51853  1.000 44.21916 ? 27  LEU A CB  1 
ATOM   182  C CG  . LEU A 1 25  ? 8.44940  -9.78306  20.27891  1.000 48.99171 ? 27  LEU A CG  1 
ATOM   183  C CD1 . LEU A 1 25  ? 9.13393  -10.90345 19.49883  1.000 41.36756 ? 27  LEU A CD1 1 
ATOM   184  C CD2 . LEU A 1 25  ? 9.44558  -8.66526  20.62863  1.000 38.95407 ? 27  LEU A CD2 1 
ATOM   185  N N   . ASN A 1 26  ? 6.48190  -10.55900 17.01766  1.000 39.46564 ? 28  ASN A N   1 
ATOM   186  C CA  . ASN A 1 26  ? 6.44959  -11.34310 15.79113  1.000 39.10611 ? 28  ASN A CA  1 
ATOM   187  C C   . ASN A 1 26  ? 7.82298  -11.92064 15.46024  1.000 40.80809 ? 28  ASN A C   1 
ATOM   188  O O   . ASN A 1 26  ? 8.85781  -11.31322 15.73561  1.000 40.76968 ? 28  ASN A O   1 
ATOM   189  C CB  . ASN A 1 26  ? 5.95194  -10.49595 14.61519  1.000 37.37131 ? 28  ASN A CB  1 
ATOM   190  C CG  . ASN A 1 26  ? 4.66088  -9.73856  14.93197  1.000 43.36302 ? 28  ASN A CG  1 
ATOM   191  O OD1 . ASN A 1 26  ? 3.57210  -10.31319 14.87760  1.000 47.55308 ? 28  ASN A OD1 1 
ATOM   192  N ND2 . ASN A 1 26  ? 4.77709  -8.44151  15.25534  1.000 39.24515 ? 28  ASN A ND2 1 
ATOM   193  N N   . GLY A 1 27  ? 7.82000  -13.11068 14.86610  1.000 42.14809 ? 29  GLY A N   1 
ATOM   194  C CA  . GLY A 1 27  ? 9.04331  -13.72891 14.40137  1.000 38.18463 ? 29  GLY A CA  1 
ATOM   195  C C   . GLY A 1 27  ? 8.97383  -14.05046 12.92276  1.000 38.79910 ? 29  GLY A C   1 
ATOM   196  O O   . GLY A 1 27  ? 7.88695  -14.06801 12.35120  1.000 41.66225 ? 29  GLY A O   1 
ATOM   197  N N   . LEU A 1 28  ? 10.11437 -14.30003 12.28733  1.000 38.30947 ? 30  LEU A N   1 
ATOM   198  C CA  . LEU A 1 28  ? 10.17464 -14.66251 10.87413  1.000 39.84281 ? 30  LEU A CA  1 
ATOM   199  C C   . LEU A 1 28  ? 10.73589 -16.07073 10.74948  1.000 40.13764 ? 30  LEU A C   1 
ATOM   200  O O   . LEU A 1 28  ? 11.87664 -16.32417 11.14631  1.000 38.55254 ? 30  LEU A O   1 
ATOM   201  C CB  . LEU A 1 28  ? 11.04018 -13.68149 10.07428  1.000 36.72211 ? 30  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 28  ? 11.15201 -14.07471 8.59789   1.000 36.60098 ? 30  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 28  ? 9.84134  -13.75582 7.89504   1.000 35.85721 ? 30  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 28  ? 12.31271 -13.38010 7.92166   1.000 34.58689 ? 30  LEU A CD2 1 
ATOM   205  N N   . TRP A 1 29  ? 9.95910  -16.96491 10.16246  1.000 41.56049 ? 31  TRP A N   1 
ATOM   206  C CA  . TRP A 1 29  ? 10.23246 -18.39940 10.19854  1.000 41.60050 ? 31  TRP A CA  1 
ATOM   207  C C   . TRP A 1 29  ? 10.66212 -18.84720 8.80777   1.000 42.18452 ? 31  TRP A C   1 
ATOM   208  O O   . TRP A 1 29  ? 9.83108  -18.97909 7.90384   1.000 42.84594 ? 31  TRP A O   1 
ATOM   209  C CB  . TRP A 1 29  ? 8.99421  -19.14150 10.69651  1.000 43.57525 ? 31  TRP A CB  1 
ATOM   210  C CG  . TRP A 1 29  ? 9.14544  -20.62757 10.77186  1.000 48.93994 ? 31  TRP A CG  1 
ATOM   211  C CD1 . TRP A 1 29  ? 10.30851 -21.34105 10.88065  1.000 46.86044 ? 31  TRP A CD1 1 
ATOM   212  C CD2 . TRP A 1 29  ? 8.08693  -21.58809 10.71548  1.000 49.58821 ? 31  TRP A CD2 1 
ATOM   213  N NE1 . TRP A 1 29  ? 10.03416 -22.68874 10.89324  1.000 45.99507 ? 31  TRP A NE1 1 
ATOM   214  C CE2 . TRP A 1 29  ? 8.67692  -22.86482 10.79768  1.000 51.32035 ? 31  TRP A CE2 1 
ATOM   215  C CE3 . TRP A 1 29  ? 6.69256  -21.49082 10.61023  1.000 47.34000 ? 31  TRP A CE3 1 
ATOM   216  C CZ2 . TRP A 1 29  ? 7.91923  -24.03398 10.78109  1.000 53.34689 ? 31  TRP A CZ2 1 
ATOM   217  C CZ3 . TRP A 1 29  ? 5.94700  -22.65064 10.58153  1.000 47.56455 ? 31  TRP A CZ3 1 
ATOM   218  C CH2 . TRP A 1 29  ? 6.55907  -23.90553 10.66529  1.000 45.28908 ? 31  TRP A CH2 1 
ATOM   219  N N   . LEU A 1 30  ? 11.96850 -19.05925 8.63957   1.000 42.85646 ? 32  LEU A N   1 
ATOM   220  C CA  . LEU A 1 30  ? 12.57840 -19.46132 7.37243   1.000 41.87539 ? 32  LEU A CA  1 
ATOM   221  C C   . LEU A 1 30  ? 13.30926 -20.78329 7.57518   1.000 47.70720 ? 32  LEU A C   1 
ATOM   222  O O   . LEU A 1 30  ? 14.22722 -20.86355 8.40028   1.000 44.84382 ? 32  LEU A O   1 
ATOM   223  C CB  . LEU A 1 30  ? 13.55667 -18.40212 6.87501   1.000 35.94600 ? 32  LEU A CB  1 
ATOM   224  C CG  . LEU A 1 30  ? 12.97887 -17.02095 6.55965   1.000 44.29333 ? 32  LEU A CG  1 
ATOM   225  C CD1 . LEU A 1 30  ? 14.10758 -15.99151 6.35254   1.000 34.31134 ? 32  LEU A CD1 1 
ATOM   226  C CD2 . LEU A 1 30  ? 12.03657 -17.09581 5.35575   1.000 34.71127 ? 32  LEU A CD2 1 
ATOM   227  N N   . ASP A 1 31  ? 12.92529 -21.80199 6.80544   1.000 46.00135 ? 33  ASP A N   1 
ATOM   228  C CA  . ASP A 1 31  ? 13.35936 -23.16791 7.07179   1.000 48.13164 ? 33  ASP A CA  1 
ATOM   229  C C   . ASP A 1 31  ? 13.15730 -23.48203 8.55927   1.000 51.41536 ? 33  ASP A C   1 
ATOM   230  O O   . ASP A 1 31  ? 12.03811 -23.34718 9.07244   1.000 49.49308 ? 33  ASP A O   1 
ATOM   231  C CB  . ASP A 1 31  ? 14.81597 -23.36223 6.62758   1.000 46.99241 ? 33  ASP A CB  1 
ATOM   232  C CG  . ASP A 1 31  ? 15.11928 -22.69843 5.28204   1.000 49.36889 ? 33  ASP A CG  1 
ATOM   233  O OD1 . ASP A 1 31  ? 14.39796 -22.95887 4.28923   1.000 53.32240 ? 33  ASP A OD1 1 
ATOM   234  O OD2 . ASP A 1 31  ? 16.09738 -21.92291 5.20365   1.000 51.71664 ? 33  ASP A OD2 1 
ATOM   235  N N   . ASP A 1 32  ? 14.22707 -23.84370 9.27797   1.000 47.72666 ? 34  ASP A N   1 
ATOM   236  C CA  . ASP A 1 32  ? 14.13302 -24.27378 10.67146  1.000 53.26209 ? 34  ASP A CA  1 
ATOM   237  C C   . ASP A 1 32  ? 14.58967 -23.20547 11.67160  1.000 54.61436 ? 34  ASP A C   1 
ATOM   238  O O   . ASP A 1 32  ? 15.03745 -23.54848 12.77372  1.000 51.86488 ? 34  ASP A O   1 
ATOM   239  C CB  . ASP A 1 32  ? 14.94656 -25.55316 10.88253  1.000 51.52839 ? 34  ASP A CB  1 
ATOM   240  C CG  . ASP A 1 32  ? 16.41889 -25.38253 10.50464  1.000 60.48390 ? 34  ASP A CG  1 
ATOM   241  O OD1 . ASP A 1 32  ? 16.71940 -24.55162 9.61525   1.000 62.13307 ? 34  ASP A OD1 1 
ATOM   242  O OD2 . ASP A 1 32  ? 17.27456 -26.09863 11.07416  1.000 64.22495 ? 34  ASP A OD2 1 
ATOM   243  N N   . VAL A 1 33  ? 14.48132 -21.92218 11.33203  1.000 47.76308 ? 35  VAL A N   1 
ATOM   244  C CA  . VAL A 1 33  ? 14.98629 -20.85165 12.18941  1.000 47.91462 ? 35  VAL A CA  1 
ATOM   245  C C   . VAL A 1 33  ? 13.93643 -19.75448 12.28786  1.000 48.81176 ? 35  VAL A C   1 
ATOM   246  O O   . VAL A 1 33  ? 13.37515 -19.33642 11.26804  1.000 47.25594 ? 35  VAL A O   1 
ATOM   247  C CB  . VAL A 1 33  ? 16.30263 -20.26175 11.65504  1.000 48.21503 ? 35  VAL A CB  1 
ATOM   248  C CG1 . VAL A 1 33  ? 16.73753 -19.05566 12.52440  1.000 44.12747 ? 35  VAL A CG1 1 
ATOM   249  C CG2 . VAL A 1 33  ? 17.37307 -21.33068 11.56275  1.000 44.66534 ? 35  VAL A CG2 1 
ATOM   250  N N   . VAL A 1 34  ? 13.67823 -19.27860 13.50287  1.000 43.83381 ? 36  VAL A N   1 
ATOM   251  C CA  . VAL A 1 34  ? 12.78179 -18.15028 13.71044  1.000 43.47549 ? 36  VAL A CA  1 
ATOM   252  C C   . VAL A 1 34  ? 13.62592 -16.95204 14.11346  1.000 43.97716 ? 36  VAL A C   1 
ATOM   253  O O   . VAL A 1 34  ? 14.29417 -16.96783 15.15586  1.000 45.75263 ? 36  VAL A O   1 
ATOM   254  C CB  . VAL A 1 34  ? 11.68989 -18.43884 14.75415  1.000 46.71745 ? 36  VAL A CB  1 
ATOM   255  C CG1 . VAL A 1 34  ? 10.92048 -17.15411 15.06223  1.000 39.85824 ? 36  VAL A CG1 1 
ATOM   256  C CG2 . VAL A 1 34  ? 10.72899 -19.49152 14.24551  1.000 42.44845 ? 36  VAL A CG2 1 
ATOM   257  N N   . TYR A 1 35  ? 13.59870 -15.91968 13.27572  1.000 42.29046 ? 37  TYR A N   1 
ATOM   258  C CA  . TYR A 1 35  ? 14.27136 -14.66357 13.54956  1.000 37.47009 ? 37  TYR A CA  1 
ATOM   259  C C   . TYR A 1 35  ? 13.28561 -13.73796 14.24651  1.000 36.94883 ? 37  TYR A C   1 
ATOM   260  O O   . TYR A 1 35  ? 12.13730 -13.59397 13.81501  1.000 38.97891 ? 37  TYR A O   1 
ATOM   261  C CB  . TYR A 1 35  ? 14.78986 -14.04310 12.24828  1.000 36.57161 ? 37  TYR A CB  1 
ATOM   262  C CG  . TYR A 1 35  ? 15.70926 -14.96734 11.48128  1.000 39.86406 ? 37  TYR A CG  1 
ATOM   263  C CD1 . TYR A 1 35  ? 15.20175 -16.02981 10.71292  1.000 39.07079 ? 37  TYR A CD1 1 
ATOM   264  C CD2 . TYR A 1 35  ? 17.08566 -14.80574 11.53781  1.000 40.35887 ? 37  TYR A CD2 1 
ATOM   265  C CE1 . TYR A 1 35  ? 16.05486 -16.89946 10.01534  1.000 38.55532 ? 37  TYR A CE1 1 
ATOM   266  C CE2 . TYR A 1 35  ? 17.94427 -15.67151 10.84624  1.000 38.22545 ? 37  TYR A CE2 1 
ATOM   267  C CZ  . TYR A 1 35  ? 17.42571 -16.70642 10.09112  1.000 40.72552 ? 37  TYR A CZ  1 
ATOM   268  O OH  . TYR A 1 35  ? 18.29493 -17.53468 9.41487   1.000 42.90893 ? 37  TYR A OH  1 
ATOM   269  N N   . CYS A 1 36  ? 13.71896 -13.14054 15.34216  1.000 32.89647 ? 38  CYS A N   1 
ATOM   270  C CA  . CYS A 1 36  ? 12.92293 -12.14877 16.03554  1.000 34.49316 ? 38  CYS A CA  1 
ATOM   271  C C   . CYS A 1 36  ? 13.88409 -11.20953 16.74745  1.000 34.74415 ? 38  CYS A C   1 
ATOM   272  O O   . CYS A 1 36  ? 15.06053 -11.54268 16.92090  1.000 34.34424 ? 38  CYS A O   1 
ATOM   273  C CB  . CYS A 1 36  ? 11.95656 -12.80630 17.03329  1.000 42.14461 ? 38  CYS A CB  1 
ATOM   274  S SG  . CYS A 1 36  ? 12.77210 -13.44256 18.55528  1.000 45.90696 ? 38  CYS A SG  1 
ATOM   275  N N   . PRO A 1 37  ? 13.42439 -10.03967 17.15254  1.000 32.54366 ? 39  PRO A N   1 
ATOM   276  C CA  . PRO A 1 37  ? 14.32165 -9.14219  17.88353  1.000 35.90840 ? 39  PRO A CA  1 
ATOM   277  C C   . PRO A 1 37  ? 14.68593 -9.74741  19.22757  1.000 40.26415 ? 39  PRO A C   1 
ATOM   278  O O   . PRO A 1 37  ? 13.90322 -10.47438 19.84989  1.000 41.27451 ? 39  PRO A O   1 
ATOM   279  C CB  . PRO A 1 37  ? 13.49523 -7.86151  18.04943  1.000 38.06374 ? 39  PRO A CB  1 
ATOM   280  C CG  . PRO A 1 37  ? 12.27870 -8.05552  17.12703  1.000 38.05713 ? 39  PRO A CG  1 
ATOM   281  C CD  . PRO A 1 37  ? 12.05592 -9.51338  17.08065  1.000 32.60059 ? 39  PRO A CD  1 
ATOM   282  N N   . ARG A 1 38  ? 15.90061 -9.46254  19.66011  1.000 35.82274 ? 40  ARG A N   1 
ATOM   283  C CA  . ARG A 1 38  ? 16.36285 -10.00524 20.92315  1.000 39.12141 ? 40  ARG A CA  1 
ATOM   284  C C   . ARG A 1 38  ? 15.77338 -9.28461  22.12412  1.000 40.43330 ? 40  ARG A C   1 
ATOM   285  O O   . ARG A 1 38  ? 15.89683 -9.79207  23.24521  1.000 39.31712 ? 40  ARG A O   1 
ATOM   286  C CB  . ARG A 1 38  ? 17.89343 -9.95829  20.99659  1.000 41.02945 ? 40  ARG A CB  1 
ATOM   287  C CG  . ARG A 1 38  ? 18.43846 -8.63529  21.47414  1.000 38.94410 ? 40  ARG A CG  1 
ATOM   288  C CD  . ARG A 1 38  ? 19.91748 -8.69638  21.75754  1.000 38.03799 ? 40  ARG A CD  1 
ATOM   289  N NE  . ARG A 1 38  ? 20.50872 -7.36117  21.69052  1.000 37.07242 ? 40  ARG A NE  1 
ATOM   290  C CZ  . ARG A 1 38  ? 21.81626 -7.12364  21.77894  1.000 42.12588 ? 40  ARG A CZ  1 
ATOM   291  N NH1 . ARG A 1 38  ? 22.67468 -8.13560  21.93712  1.000 36.45383 ? 40  ARG A NH1 1 
ATOM   292  N NH2 . ARG A 1 38  ? 22.27092 -5.87585  21.70046  1.000 33.86224 ? 40  ARG A NH2 1 
ATOM   293  N N   . HIS A 1 39  ? 15.12183 -8.13129  21.94050  1.000 41.65077 ? 41  HIS A N   1 
ATOM   294  C CA  . HIS A 1 39  ? 14.57411 -7.48990  23.12799  1.000 42.42485 ? 41  HIS A CA  1 
ATOM   295  C C   . HIS A 1 39  ? 13.31408 -8.17948  23.63043  1.000 46.37212 ? 41  HIS A C   1 
ATOM   296  O O   . HIS A 1 39  ? 12.75002 -7.72438  24.63794  1.000 43.42662 ? 41  HIS A O   1 
ATOM   297  C CB  . HIS A 1 39  ? 14.34269 -5.97932  22.91282  1.000 42.76047 ? 41  HIS A CB  1 
ATOM   298  C CG  . HIS A 1 39  ? 13.32317 -5.61901  21.87044  1.000 44.88039 ? 41  HIS A CG  1 
ATOM   299  N ND1 . HIS A 1 39  ? 12.01574 -6.05890  21.90679  1.000 43.45657 ? 41  HIS A ND1 1 
ATOM   300  C CD2 . HIS A 1 39  ? 13.41269 -4.79978  20.79403  1.000 38.94009 ? 41  HIS A CD2 1 
ATOM   301  C CE1 . HIS A 1 39  ? 11.35219 -5.54798  20.88349  1.000 45.16122 ? 41  HIS A CE1 1 
ATOM   302  N NE2 . HIS A 1 39  ? 12.17648 -4.77691  20.19564  1.000 43.40071 ? 41  HIS A NE2 1 
ATOM   303  N N   . VAL A 1 40  ? 12.89960 -9.28046  22.97947  1.000 39.14823 ? 42  VAL A N   1 
ATOM   304  C CA  . VAL A 1 40  ? 11.81150 -10.11740 23.48361  1.000 43.24093 ? 42  VAL A CA  1 
ATOM   305  C C   . VAL A 1 40  ? 12.11017 -10.63719 24.89248  1.000 52.20918 ? 42  VAL A C   1 
ATOM   306  O O   . VAL A 1 40  ? 11.18762 -10.87153 25.68525  1.000 53.13929 ? 42  VAL A O   1 
ATOM   307  C CB  . VAL A 1 40  ? 11.53312 -11.27738 22.49761  1.000 45.98029 ? 42  VAL A CB  1 
ATOM   308  C CG1 . VAL A 1 40  ? 12.70902 -12.27017 22.43079  1.000 37.70666 ? 42  VAL A CG1 1 
ATOM   309  C CG2 . VAL A 1 40  ? 10.22911 -11.98119 22.84379  1.000 46.36597 ? 42  VAL A CG2 1 
ATOM   310  N N   . ILE A 1 41  ? 13.39294 -10.79724 25.23990  1.000 49.44367 ? 43  ILE A N   1 
ATOM   311  C CA  . ILE A 1 41  ? 13.77414 -11.36258 26.52943  1.000 48.80583 ? 43  ILE A CA  1 
ATOM   312  C C   . ILE A 1 41  ? 13.88944 -10.31672 27.63527  1.000 50.97907 ? 43  ILE A C   1 
ATOM   313  O O   . ILE A 1 41  ? 14.16697 -10.67779 28.78394  1.000 53.85519 ? 43  ILE A O   1 
ATOM   314  C CB  . ILE A 1 41  ? 15.10167 -12.13344 26.38587  1.000 48.05604 ? 43  ILE A CB  1 
ATOM   315  C CG1 . ILE A 1 41  ? 16.27132 -11.15164 26.22114  1.000 49.11640 ? 43  ILE A CG1 1 
ATOM   316  C CG2 . ILE A 1 41  ? 15.01474 -13.08759 25.20637  1.000 41.60870 ? 43  ILE A CG2 1 
ATOM   317  C CD1 . ILE A 1 41  ? 17.63655 -11.80821 25.99712  1.000 48.79650 ? 43  ILE A CD1 1 
ATOM   318  N N   . CYS A 1 42  ? 13.67565 -9.03965  27.33605  1.000 51.47828 ? 44  CYS A N   1 
ATOM   319  C CA  . CYS A 1 42  ? 13.71274 -8.00598  28.36311  1.000 57.18163 ? 44  CYS A CA  1 
ATOM   320  C C   . CYS A 1 42  ? 12.48596 -8.05959  29.25186  1.000 61.95092 ? 44  CYS A C   1 
ATOM   321  O O   . CYS A 1 42  ? 11.36189 -8.22912  28.77112  1.000 63.63576 ? 44  CYS A O   1 
ATOM   322  C CB  . CYS A 1 42  ? 13.77712 -6.61814  27.74046  1.000 57.00331 ? 44  CYS A CB  1 
ATOM   323  S SG  . CYS A 1 42  ? 15.41941 -6.05945  27.38966  1.000 70.25485 ? 44  CYS A SG  1 
ATOM   324  N N   . THR A 1 43  ? 12.70356 -7.88451  30.54907  1.000 64.06083 ? 45  THR A N   1 
ATOM   325  C CA  . THR A 1 43  ? 11.61830 -7.58461  31.46774  1.000 63.02389 ? 45  THR A CA  1 
ATOM   326  C C   . THR A 1 43  ? 11.61618 -6.09618  31.72556  1.000 59.81395 ? 45  THR A C   1 
ATOM   327  O O   . THR A 1 43  ? 12.61750 -5.41179  31.50917  1.000 62.92897 ? 45  THR A O   1 
ATOM   328  C CB  . THR A 1 43  ? 11.76071 -8.32944  32.79426  1.000 60.34876 ? 45  THR A CB  1 
ATOM   329  O OG1 . THR A 1 43  ? 12.87964 -7.79749  33.51837  1.000 61.64759 ? 45  THR A OG1 1 
ATOM   330  C CG2 . THR A 1 43  ? 11.94993 -9.81095  32.54790  1.000 57.35383 ? 45  THR A CG2 1 
ATOM   331  N N   . SER A 1 44  ? 10.47908 -5.60047  32.21127  1.000 60.43016 ? 46  SER A N   1 
ATOM   332  C CA  . SER A 1 44  ? 10.36799 -4.17657  32.48226  1.000 60.11166 ? 46  SER A CA  1 
ATOM   333  C C   . SER A 1 44  ? 11.38183 -3.73269  33.52192  1.000 61.69661 ? 46  SER A C   1 
ATOM   334  O O   . SER A 1 44  ? 11.66717 -2.53691  33.63483  1.000 65.11500 ? 46  SER A O   1 
ATOM   335  C CB  . SER A 1 44  ? 8.94636  -3.84573  32.92566  1.000 66.43467 ? 46  SER A CB  1 
ATOM   336  O OG  . SER A 1 44  ? 8.60873  -2.52096  32.53718  1.000 76.87454 ? 46  SER A OG  1 
ATOM   337  N N   . GLU A 1 45  ? 11.96042 -4.68110  34.25319  1.000 65.03430 ? 47  GLU A N   1 
ATOM   338  C CA  . GLU A 1 45  ? 12.96882 -4.37523  35.25259  1.000 65.10086 ? 47  GLU A CA  1 
ATOM   339  C C   . GLU A 1 45  ? 14.32176 -4.03544  34.64808  1.000 65.20127 ? 47  GLU A C   1 
ATOM   340  O O   . GLU A 1 45  ? 15.11752 -3.36868  35.30834  1.000 68.90286 ? 47  GLU A O   1 
ATOM   341  C CB  . GLU A 1 45  ? 13.13053 -5.56752  36.18621  1.000 73.20952 ? 47  GLU A CB  1 
ATOM   342  C CG  . GLU A 1 45  ? 12.42688 -5.44718  37.51686  1.000 81.03466 ? 47  GLU A CG  1 
ATOM   343  C CD  . GLU A 1 45  ? 12.72333 -6.64111  38.40547  1.000 88.42076 ? 47  GLU A CD  1 
ATOM   344  O OE1 . GLU A 1 45  ? 12.49979 -6.55845  39.63224  1.000 88.09314 ? 47  GLU A OE1 1 
ATOM   345  O OE2 . GLU A 1 45  ? 13.18553 -7.67108  37.86608  1.000 89.60766 ? 47  GLU A OE2 1 
ATOM   346  N N   . ASP A 1 46  ? 14.61510 -4.48739  33.42542  1.000 67.71100 ? 48  ASP A N   1 
ATOM   347  C CA  . ASP A 1 46  ? 15.95547 -4.35622  32.85372  1.000 67.93863 ? 48  ASP A CA  1 
ATOM   348  C C   . ASP A 1 46  ? 16.00285 -3.48353  31.59948  1.000 63.82031 ? 48  ASP A C   1 
ATOM   349  O O   . ASP A 1 46  ? 17.07464 -3.33674  30.99360  1.000 60.07343 ? 48  ASP A O   1 
ATOM   350  C CB  . ASP A 1 46  ? 16.52681 -5.74675  32.54992  1.000 68.33351 ? 48  ASP A CB  1 
ATOM   351  C CG  . ASP A 1 46  ? 17.48508 -6.23206  33.63366  1.000 69.42051 ? 48  ASP A CG  1 
ATOM   352  O OD1 . ASP A 1 46  ? 18.23107 -5.40048  34.19645  1.000 72.37223 ? 48  ASP A OD1 1 
ATOM   353  O OD2 . ASP A 1 46  ? 17.47963 -7.44338  33.93854  1.000 71.09251 ? 48  ASP A OD2 1 
ATOM   354  N N   . ILE A 1 47  ? 14.88521 -2.85698  31.22814  1.000 62.78993 ? 49  ILE A N   1 
ATOM   355  C CA  . ILE A 1 47  ? 14.77831 -2.18833  29.93444  1.000 60.98743 ? 49  ILE A CA  1 
ATOM   356  C C   . ILE A 1 47  ? 15.68970 -0.96932  29.83729  1.000 52.98369 ? 49  ILE A C   1 
ATOM   357  O O   . ILE A 1 47  ? 16.17053 -0.63927  28.74902  1.000 58.87604 ? 49  ILE A O   1 
ATOM   358  C CB  . ILE A 1 47  ? 13.30026 -1.83615  29.67020  1.000 62.82615 ? 49  ILE A CB  1 
ATOM   359  C CG1 . ILE A 1 47  ? 12.53901 -3.06477  29.16769  1.000 61.28226 ? 49  ILE A CG1 1 
ATOM   360  C CG2 . ILE A 1 47  ? 13.16902 -0.76060  28.65624  1.000 64.34983 ? 49  ILE A CG2 1 
ATOM   361  C CD1 . ILE A 1 47  ? 11.16014 -2.73750  28.56840  1.000 64.09672 ? 49  ILE A CD1 1 
ATOM   362  N N   . LEU A 1 48  ? 15.96254 -0.29233  30.94854  1.000 53.92843 ? 50  LEU A N   1 
ATOM   363  C CA  . LEU A 1 48  ? 16.80036 0.90531   30.89631  1.000 53.49113 ? 50  LEU A CA  1 
ATOM   364  C C   . LEU A 1 48  ? 18.19101 0.59506   30.35175  1.000 54.32651 ? 50  LEU A C   1 
ATOM   365  O O   . LEU A 1 48  ? 18.76122 1.38651   29.59012  1.000 56.47153 ? 50  LEU A O   1 
ATOM   366  C CB  . LEU A 1 48  ? 16.89966 1.53497   32.28751  1.000 56.20103 ? 50  LEU A CB  1 
ATOM   367  C CG  . LEU A 1 48  ? 16.70821 3.04016   32.46722  1.000 55.94819 ? 50  LEU A CG  1 
ATOM   368  C CD1 . LEU A 1 48  ? 15.39797 3.50047   31.87269  1.000 57.70853 ? 50  LEU A CD1 1 
ATOM   369  C CD2 . LEU A 1 48  ? 16.75794 3.39941   33.93785  1.000 51.55421 ? 50  LEU A CD2 1 
ATOM   370  N N   . ASN A 1 49  ? 18.76087 -0.54177  30.73417  1.000 57.02443 ? 51  ASN A N   1 
ATOM   371  C CA  . ASN A 1 49  ? 20.07237 -0.88416  30.19250  1.000 59.47005 ? 51  ASN A CA  1 
ATOM   372  C C   . ASN A 1 49  ? 20.34366 -2.37733  30.30287  1.000 54.29652 ? 51  ASN A C   1 
ATOM   373  O O   . ASN A 1 49  ? 21.13389 -2.80050  31.15048  1.000 54.82433 ? 51  ASN A O   1 
ATOM   374  C CB  . ASN A 1 49  ? 21.18120 -0.11392  30.90638  1.000 59.90843 ? 51  ASN A CB  1 
ATOM   375  C CG  . ASN A 1 49  ? 22.51166 -0.24043  30.20011  1.000 61.92184 ? 51  ASN A CG  1 
ATOM   376  O OD1 . ASN A 1 49  ? 22.57054 -0.40558  28.97853  1.000 63.32084 ? 51  ASN A OD1 1 
ATOM   377  N ND2 . ASN A 1 49  ? 23.58703 -0.19556  30.96708  1.000 59.61784 ? 51  ASN A ND2 1 
ATOM   378  N N   . PRO A 1 50  ? 19.74798 -3.19564  29.44528  1.000 53.11583 ? 52  PRO A N   1 
ATOM   379  C CA  . PRO A 1 50  ? 19.84104 -4.64945  29.62192  1.000 49.43278 ? 52  PRO A CA  1 
ATOM   380  C C   . PRO A 1 50  ? 21.20325 -5.19608  29.23382  1.000 47.36547 ? 52  PRO A C   1 
ATOM   381  O O   . PRO A 1 50  ? 21.83511 -4.73547  28.28034  1.000 47.21543 ? 52  PRO A O   1 
ATOM   382  C CB  . PRO A 1 50  ? 18.75891 -5.18051  28.67882  1.000 50.77360 ? 52  PRO A CB  1 
ATOM   383  C CG  . PRO A 1 50  ? 18.72650 -4.15811  27.57198  1.000 53.28499 ? 52  PRO A CG  1 
ATOM   384  C CD  . PRO A 1 50  ? 19.12212 -2.82085  28.16635  1.000 51.28448 ? 52  PRO A CD  1 
ATOM   385  N N   . ASN A 1 51  ? 21.64411 -6.21139  29.97411  1.000 51.17043 ? 53  ASN A N   1 
ATOM   386  C CA  . ASN A 1 51  ? 22.81905 -7.00304  29.60042  1.000 50.26142 ? 53  ASN A CA  1 
ATOM   387  C C   . ASN A 1 51  ? 22.32028 -8.25823  28.88104  1.000 48.53635 ? 53  ASN A C   1 
ATOM   388  O O   . ASN A 1 51  ? 21.83889 -9.20364  29.51442  1.000 48.16993 ? 53  ASN A O   1 
ATOM   389  C CB  . ASN A 1 51  ? 23.65584 -7.33900  30.82884  1.000 48.22065 ? 53  ASN A CB  1 
ATOM   390  C CG  . ASN A 1 51  ? 25.01541 -7.86628  30.46664  1.000 51.30160 ? 53  ASN A CG  1 
ATOM   391  O OD1 . ASN A 1 51  ? 25.13396 -8.84436  29.72877  1.000 54.08514 ? 53  ASN A OD1 1 
ATOM   392  N ND2 . ASN A 1 51  ? 26.05427 -7.22842  30.98167  1.000 48.92364 ? 53  ASN A ND2 1 
ATOM   393  N N   . TYR A 1 52  ? 22.43336 -8.26927  27.55178  1.000 47.13292 ? 54  TYR A N   1 
ATOM   394  C CA  . TYR A 1 52  ? 21.71607 -9.28204  26.78804  1.000 45.03802 ? 54  TYR A CA  1 
ATOM   395  C C   . TYR A 1 52  ? 22.40742 -10.63480 26.81997  1.000 48.07507 ? 54  TYR A C   1 
ATOM   396  O O   . TYR A 1 52  ? 21.73157 -11.66228 26.93955  1.000 48.45775 ? 54  TYR A O   1 
ATOM   397  C CB  . TYR A 1 52  ? 21.52711 -8.82862  25.35479  1.000 43.11344 ? 54  TYR A CB  1 
ATOM   398  C CG  . TYR A 1 52  ? 20.39284 -7.85225  25.16441  1.000 45.02490 ? 54  TYR A CG  1 
ATOM   399  C CD1 . TYR A 1 52  ? 19.07148 -8.26756  25.27070  1.000 44.08115 ? 54  TYR A CD1 1 
ATOM   400  C CD2 . TYR A 1 52  ? 20.64360 -6.51171  24.85148  1.000 40.12949 ? 54  TYR A CD2 1 
ATOM   401  C CE1 . TYR A 1 52  ? 18.02028 -7.37524  25.06883  1.000 44.90365 ? 54  TYR A CE1 1 
ATOM   402  C CE2 . TYR A 1 52  ? 19.59830 -5.61182  24.64165  1.000 40.29695 ? 54  TYR A CE2 1 
ATOM   403  C CZ  . TYR A 1 52  ? 18.29172 -6.05276  24.74755  1.000 40.55896 ? 54  TYR A CZ  1 
ATOM   404  O OH  . TYR A 1 52  ? 17.25411 -5.18191  24.55289  1.000 39.17982 ? 54  TYR A OH  1 
ATOM   405  N N   . GLU A 1 53  ? 23.73628 -10.67676 26.69519  1.000 49.74026 ? 55  GLU A N   1 
ATOM   406  C CA  . GLU A 1 53  ? 24.41862 -11.95465 26.88994  1.000 53.55721 ? 55  GLU A CA  1 
ATOM   407  C C   . GLU A 1 53  ? 24.00528 -12.57063 28.23156  1.000 51.34734 ? 55  GLU A C   1 
ATOM   408  O O   . GLU A 1 53  ? 23.61295 -13.74320 28.29240  1.000 53.03724 ? 55  GLU A O   1 
ATOM   409  C CB  . GLU A 1 53  ? 25.94816 -11.78658 26.75738  1.000 53.38379 ? 55  GLU A CB  1 
ATOM   410  C CG  . GLU A 1 53  ? 26.70577 -11.35681 28.03112  1.000 65.27584 ? 55  GLU A CG  1 
ATOM   411  C CD  . GLU A 1 53  ? 28.21775 -11.09130 27.83302  1.000 72.79765 ? 55  GLU A CD  1 
ATOM   412  O OE1 . GLU A 1 53  ? 29.00649 -11.34164 28.78425  1.000 68.10158 ? 55  GLU A OE1 1 
ATOM   413  O OE2 . GLU A 1 53  ? 28.61476 -10.62962 26.73679  1.000 73.87320 ? 55  GLU A OE2 1 
ATOM   414  N N   . ASP A 1 54  ? 23.96445 -11.75138 29.29379  1.000 50.80670 ? 56  ASP A N   1 
ATOM   415  C CA  . ASP A 1 54  ? 23.56828 -12.23412 30.61896  1.000 51.03939 ? 56  ASP A CA  1 
ATOM   416  C C   . ASP A 1 54  ? 22.09828 -12.63311 30.65854  1.000 52.11137 ? 56  ASP A C   1 
ATOM   417  O O   . ASP A 1 54  ? 21.75262 -13.68903 31.19837  1.000 56.56801 ? 56  ASP A O   1 
ATOM   418  C CB  . ASP A 1 54  ? 23.84273 -11.16818 31.68765  1.000 55.95913 ? 56  ASP A CB  1 
ATOM   419  C CG  . ASP A 1 54  ? 25.30915 -11.12858 32.13353  1.000 57.27169 ? 56  ASP A CG  1 
ATOM   420  O OD1 . ASP A 1 54  ? 26.08087 -12.04832 31.80698  1.000 58.59846 ? 56  ASP A OD1 1 
ATOM   421  O OD2 . ASP A 1 54  ? 25.70170 -10.16893 32.82675  1.000 65.36816 ? 56  ASP A OD2 1 
ATOM   422  N N   . LEU A 1 55  ? 21.21254 -11.80286 30.10621  1.000 51.75094 ? 57  LEU A N   1 
ATOM   423  C CA  . LEU A 1 55  ? 19.79563 -12.15525 30.09217  1.000 50.13082 ? 57  LEU A CA  1 
ATOM   424  C C   . LEU A 1 55  ? 19.55050 -13.47337 29.36342  1.000 52.39428 ? 57  LEU A C   1 
ATOM   425  O O   . LEU A 1 55  ? 18.69328 -14.26950 29.76860  1.000 53.81939 ? 57  LEU A O   1 
ATOM   426  C CB  . LEU A 1 55  ? 18.98925 -11.03145 29.45254  1.000 47.61542 ? 57  LEU A CB  1 
ATOM   427  C CG  . LEU A 1 55  ? 18.66266 -9.92085  30.43394  1.000 52.37218 ? 57  LEU A CG  1 
ATOM   428  C CD1 . LEU A 1 55  ? 17.91336 -8.76506  29.77675  1.000 49.45427 ? 57  LEU A CD1 1 
ATOM   429  C CD2 . LEU A 1 55  ? 17.86719 -10.51855 31.58190  1.000 55.47614 ? 57  LEU A CD2 1 
ATOM   430  N N   . LEU A 1 56  ? 20.29104 -13.72137 28.28443  1.000 51.48329 ? 58  LEU A N   1 
ATOM   431  C CA  . LEU A 1 56  ? 20.03131 -14.89679 27.46549  1.000 54.27464 ? 58  LEU A CA  1 
ATOM   432  C C   . LEU A 1 56  ? 20.54460 -16.16643 28.12365  1.000 53.07801 ? 58  LEU A C   1 
ATOM   433  O O   . LEU A 1 56  ? 19.96490 -17.24101 27.92955  1.000 52.12853 ? 58  LEU A O   1 
ATOM   434  C CB  . LEU A 1 56  ? 20.66228 -14.72086 26.08228  1.000 53.27829 ? 58  LEU A CB  1 
ATOM   435  C CG  . LEU A 1 56  ? 20.07765 -15.66263 25.03762  1.000 51.55294 ? 58  LEU A CG  1 
ATOM   436  C CD1 . LEU A 1 56  ? 18.59997 -15.32939 24.79330  1.000 49.27197 ? 58  LEU A CD1 1 
ATOM   437  C CD2 . LEU A 1 56  ? 20.88585 -15.57319 23.76387  1.000 47.90177 ? 58  LEU A CD2 1 
ATOM   438  N N   . ILE A 1 57  ? 21.62631 -16.05309 28.89647  1.000 56.15320 ? 59  ILE A N   1 
ATOM   439  C CA  . ILE A 1 57  ? 22.12562 -17.18444 29.67275  1.000 53.30178 ? 59  ILE A CA  1 
ATOM   440  C C   . ILE A 1 57  ? 21.02805 -17.73389 30.57767  1.000 54.53594 ? 59  ILE A C   1 
ATOM   441  O O   . ILE A 1 57  ? 20.80079 -18.94968 30.63568  1.000 56.05782 ? 59  ILE A O   1 
ATOM   442  C CB  . ILE A 1 57  ? 23.37822 -16.76086 30.46939  1.000 55.38666 ? 59  ILE A CB  1 
ATOM   443  C CG1 . ILE A 1 57  ? 24.53562 -16.41880 29.51939  1.000 50.54744 ? 59  ILE A CG1 1 
ATOM   444  C CG2 . ILE A 1 57  ? 23.80843 -17.83110 31.44864  1.000 50.32276 ? 59  ILE A CG2 1 
ATOM   445  C CD1 . ILE A 1 57  ? 24.52663 -17.19996 28.21585  1.000 50.36230 ? 59  ILE A CD1 1 
ATOM   446  N N   . ARG A 1 58  ? 20.30038 -16.85108 31.26521  1.000 52.43404 ? 60  ARG A N   1 
ATOM   447  C CA  . ARG A 1 58  ? 19.23627 -17.31207 32.14842  1.000 55.92021 ? 60  ARG A CA  1 
ATOM   448  C C   . ARG A 1 58  ? 18.07684 -17.96188 31.40782  1.000 62.00865 ? 60  ARG A C   1 
ATOM   449  O O   . ARG A 1 58  ? 17.21462 -18.56478 32.06302  1.000 63.45151 ? 60  ARG A O   1 
ATOM   450  C CB  . ARG A 1 58  ? 18.70665 -16.16290 32.99506  1.000 53.17271 ? 60  ARG A CB  1 
ATOM   451  C CG  . ARG A 1 58  ? 19.75129 -15.14672 33.33697  1.000 62.49050 ? 60  ARG A CG  1 
ATOM   452  C CD  . ARG A 1 58  ? 19.17149 -13.97762 34.13142  1.000 64.77016 ? 60  ARG A CD  1 
ATOM   453  N NE  . ARG A 1 58  ? 20.14470 -12.89673 34.24407  1.000 66.33016 ? 60  ARG A NE  1 
ATOM   454  C CZ  . ARG A 1 58  ? 21.24813 -12.94275 34.99038  1.000 73.15515 ? 60  ARG A CZ  1 
ATOM   455  N NH1 . ARG A 1 58  ? 22.06828 -11.89624 35.00700  1.000 76.62647 ? 60  ARG A NH1 1 
ATOM   456  N NH2 . ARG A 1 58  ? 21.53045 -14.01424 35.73242  1.000 70.13128 ? 60  ARG A NH2 1 
ATOM   457  N N   . LYS A 1 59  ? 18.03676 -17.87471 30.07842  1.000 62.50092 ? 61  LYS A N   1 
ATOM   458  C CA  . LYS A 1 59  ? 16.92718 -18.43128 29.32296  1.000 57.52328 ? 61  LYS A CA  1 
ATOM   459  C C   . LYS A 1 59  ? 17.23214 -19.84361 28.85717  1.000 58.77991 ? 61  LYS A C   1 
ATOM   460  O O   . LYS A 1 59  ? 18.38164 -20.20321 28.57544  1.000 58.30080 ? 61  LYS A O   1 
ATOM   461  C CB  . LYS A 1 59  ? 16.58086 -17.55296 28.12415  1.000 52.42444 ? 61  LYS A CB  1 
ATOM   462  C CG  . LYS A 1 59  ? 15.24204 -16.87190 28.28901  1.000 55.73645 ? 61  LYS A CG  1 
ATOM   463  C CD  . LYS A 1 59  ? 15.34202 -15.67305 29.21227  1.000 53.09345 ? 61  LYS A CD  1 
ATOM   464  C CE  . LYS A 1 59  ? 14.01220 -14.95225 29.30818  1.000 53.63377 ? 61  LYS A CE  1 
ATOM   465  N NZ  . LYS A 1 59  ? 13.10290 -15.62017 30.28258  1.000 63.80690 ? 61  LYS A NZ  1 
ATOM   466  N N   . SER A 1 60  ? 16.17382 -20.64184 28.79098  1.000 57.09119 ? 62  SER A N   1 
ATOM   467  C CA  . SER A 1 60  ? 16.20942 -21.99545 28.26771  1.000 63.41534 ? 62  SER A CA  1 
ATOM   468  C C   . SER A 1 60  ? 15.22479 -22.09816 27.11195  1.000 62.33346 ? 62  SER A C   1 
ATOM   469  O O   . SER A 1 60  ? 14.20553 -21.39948 27.08994  1.000 57.11051 ? 62  SER A O   1 
ATOM   470  C CB  . SER A 1 60  ? 15.86062 -23.00814 29.35715  1.000 63.32041 ? 62  SER A CB  1 
ATOM   471  O OG  . SER A 1 60  ? 14.81343 -22.50113 30.17246  1.000 62.06151 ? 62  SER A OG  1 
ATOM   472  N N   . ASN A 1 61  ? 15.54289 -22.97894 26.15634  1.000 66.45838 ? 63  ASN A N   1 
ATOM   473  C CA  . ASN A 1 61  ? 14.75984 -23.16535 24.93546  1.000 60.82640 ? 63  ASN A CA  1 
ATOM   474  C C   . ASN A 1 61  ? 13.26569 -23.12361 25.22249  1.000 59.53201 ? 63  ASN A C   1 
ATOM   475  O O   . ASN A 1 61  ? 12.50663 -22.50860 24.47296  1.000 61.19012 ? 63  ASN A O   1 
ATOM   476  C CB  . ASN A 1 61  ? 15.12522 -24.48253 24.24684  1.000 55.92450 ? 63  ASN A CB  1 
ATOM   477  C CG  . ASN A 1 61  ? 16.61598 -24.76158 24.27249  1.000 69.36856 ? 63  ASN A CG  1 
ATOM   478  O OD1 . ASN A 1 61  ? 17.24311 -24.79568 25.34085  1.000 76.26547 ? 63  ASN A OD1 1 
ATOM   479  N ND2 . ASN A 1 61  ? 17.19604 -24.96884 23.09633  1.000 70.10844 ? 63  ASN A ND2 1 
ATOM   480  N N   . HIS A 1 62  ? 12.83445 -23.70605 26.33397  1.000 58.94614 ? 64  HIS A N   1 
ATOM   481  C CA  . HIS A 1 62  ? 11.41717 -23.76756 26.65733  1.000 59.44796 ? 64  HIS A CA  1 
ATOM   482  C C   . HIS A 1 62  ? 10.89584 -22.50742 27.36018  1.000 63.03172 ? 64  HIS A C   1 
ATOM   483  O O   . HIS A 1 62  ? 9.77098  -22.51671 27.87031  1.000 61.79026 ? 64  HIS A O   1 
ATOM   484  C CB  . HIS A 1 62  ? 11.14405 -25.00760 27.50751  1.000 66.16356 ? 64  HIS A CB  1 
ATOM   485  C CG  . HIS A 1 62  ? 11.87948 -24.99679 28.80118  1.000 65.38570 ? 64  HIS A CG  1 
ATOM   486  N ND1 . HIS A 1 62  ? 11.47541 -24.22890 29.87214  1.000 67.38195 ? 64  HIS A ND1 1 
ATOM   487  C CD2 . HIS A 1 62  ? 13.01881 -25.61602 29.18578  1.000 65.13902 ? 64  HIS A CD2 1 
ATOM   488  C CE1 . HIS A 1 62  ? 12.32425 -24.39138 30.87063  1.000 66.86865 ? 64  HIS A CE1 1 
ATOM   489  N NE2 . HIS A 1 62  ? 13.26856 -25.23060 30.48097  1.000 70.68696 ? 64  HIS A NE2 1 
ATOM   490  N N   . ASN A 1 63  ? 11.67442 -21.42867 27.41100  1.000 63.63815 ? 65  ASN A N   1 
ATOM   491  C CA  . ASN A 1 63  ? 11.12521 -20.13024 27.78652  1.000 56.74971 ? 65  ASN A CA  1 
ATOM   492  C C   . ASN A 1 63  ? 10.57788 -19.37348 26.58091  1.000 58.64132 ? 65  ASN A C   1 
ATOM   493  O O   . ASN A 1 63  ? 10.03654 -18.27044 26.74017  1.000 57.87531 ? 65  ASN A O   1 
ATOM   494  C CB  . ASN A 1 63  ? 12.19193 -19.27859 28.47813  1.000 54.77592 ? 65  ASN A CB  1 
ATOM   495  C CG  . ASN A 1 63  ? 12.30493 -19.56380 29.96451  1.000 61.46762 ? 65  ASN A CG  1 
ATOM   496  O OD1 . ASN A 1 63  ? 13.14578 -20.35944 30.39207  1.000 62.90487 ? 65  ASN A OD1 1 
ATOM   497  N ND2 . ASN A 1 63  ? 11.46514 -18.90830 30.76174  1.000 59.66387 ? 65  ASN A ND2 1 
ATOM   498  N N   . PHE A 1 64  ? 10.69139 -19.95621 25.39233  1.000 55.96903 ? 66  PHE A N   1 
ATOM   499  C CA  . PHE A 1 64  ? 10.45290 -19.27681 24.12303  1.000 60.40940 ? 66  PHE A CA  1 
ATOM   500  C C   . PHE A 1 64  ? 9.23198  -19.90924 23.45573  1.000 56.49538 ? 66  PHE A C   1 
ATOM   501  O O   . PHE A 1 64  ? 9.33977  -20.95677 22.81511  1.000 55.57190 ? 66  PHE A O   1 
ATOM   502  C CB  . PHE A 1 64  ? 11.68626 -19.38312 23.22493  1.000 57.33581 ? 66  PHE A CB  1 
ATOM   503  C CG  . PHE A 1 64  ? 12.85108 -18.52809 23.66669  1.000 57.18007 ? 66  PHE A CG  1 
ATOM   504  C CD1 . PHE A 1 64  ? 12.73388 -17.13910 23.74047  1.000 56.41227 ? 66  PHE A CD1 1 
ATOM   505  C CD2 . PHE A 1 64  ? 14.07012 -19.10833 23.98706  1.000 54.52076 ? 66  PHE A CD2 1 
ATOM   506  C CE1 . PHE A 1 64  ? 13.81445 -16.35129 24.12722  1.000 50.62540 ? 66  PHE A CE1 1 
ATOM   507  C CE2 . PHE A 1 64  ? 15.15621 -18.32498 24.37364  1.000 53.81264 ? 66  PHE A CE2 1 
ATOM   508  C CZ  . PHE A 1 64  ? 15.02696 -16.95229 24.44923  1.000 49.31488 ? 66  PHE A CZ  1 
ATOM   509  N N   . LEU A 1 65  ? 8.06942  -19.27593 23.59084  1.000 58.46361 ? 67  LEU A N   1 
ATOM   510  C CA  . LEU A 1 65  ? 6.84713  -19.78455 22.96410  1.000 66.94425 ? 67  LEU A CA  1 
ATOM   511  C C   . LEU A 1 65  ? 6.73419  -19.23881 21.54239  1.000 63.47720 ? 67  LEU A C   1 
ATOM   512  O O   . LEU A 1 65  ? 6.45161  -18.04658 21.35726  1.000 60.04556 ? 67  LEU A O   1 
ATOM   513  C CB  . LEU A 1 65  ? 5.60197  -19.39765 23.75858  1.000 66.87955 ? 67  LEU A CB  1 
ATOM   514  C CG  . LEU A 1 65  ? 5.52633  -19.67923 25.24494  1.000 68.40752 ? 67  LEU A CG  1 
ATOM   515  C CD1 . LEU A 1 65  ? 4.10436  -19.35531 25.77635  1.000 62.70701 ? 67  LEU A CD1 1 
ATOM   516  C CD2 . LEU A 1 65  ? 5.98282  -21.10046 25.53006  1.000 66.16432 ? 67  LEU A CD2 1 
ATOM   517  N N   . VAL A 1 66  ? 6.90973  -20.12180 20.55411  1.000 59.46072 ? 68  VAL A N   1 
ATOM   518  C CA  . VAL A 1 66  ? 6.77704  -19.81017 19.13603  1.000 61.96748 ? 68  VAL A CA  1 
ATOM   519  C C   . VAL A 1 66  ? 5.50081  -20.45280 18.60396  1.000 62.64639 ? 68  VAL A C   1 
ATOM   520  O O   . VAL A 1 66  ? 5.32976  -21.67059 18.70876  1.000 62.32036 ? 68  VAL A O   1 
ATOM   521  C CB  . VAL A 1 66  ? 8.00110  -20.31285 18.35381  1.000 59.66714 ? 68  VAL A CB  1 
ATOM   522  C CG1 . VAL A 1 66  ? 7.82022  -20.04960 16.85913  1.000 55.68299 ? 68  VAL A CG1 1 
ATOM   523  C CG2 . VAL A 1 66  ? 9.27076  -19.67318 18.88470  1.000 55.19209 ? 68  VAL A CG2 1 
ATOM   524  N N   . GLN A 1 67  ? 4.61571  -19.65496 18.00877  1.000 61.88359 ? 69  GLN A N   1 
ATOM   525  C CA  . GLN A 1 67  ? 3.37297  -20.19488 17.46664  1.000 60.53097 ? 69  GLN A CA  1 
ATOM   526  C C   . GLN A 1 67  ? 3.23742  -19.82483 15.99310  1.000 57.90743 ? 69  GLN A C   1 
ATOM   527  O O   . GLN A 1 67  ? 3.31764  -18.64733 15.63523  1.000 52.00925 ? 69  GLN A O   1 
ATOM   528  C CB  . GLN A 1 67  ? 2.16779  -19.70562 18.28097  1.000 65.77469 ? 69  GLN A CB  1 
ATOM   529  C CG  . GLN A 1 67  ? 0.97793  -20.67179 18.24494  1.000 73.68017 ? 69  GLN A CG  1 
ATOM   530  C CD  . GLN A 1 67  ? -0.13127 -20.31716 19.22192  1.000 78.32071 ? 69  GLN A CD  1 
ATOM   531  O OE1 . GLN A 1 67  ? -1.30889 -20.57093 18.95995  1.000 82.62074 ? 69  GLN A OE1 1 
ATOM   532  N NE2 . GLN A 1 67  ? 0.24102  -19.74495 20.36023  1.000 76.06593 ? 69  GLN A NE2 1 
ATOM   533  N N   . ALA A 1 68  ? 3.05121  -20.83304 15.13787  1.000 65.41559 ? 70  ALA A N   1 
ATOM   534  C CA  . ALA A 1 68  ? 2.77010  -20.63997 13.71823  1.000 61.72749 ? 70  ALA A CA  1 
ATOM   535  C C   . ALA A 1 68  ? 1.27156  -20.80781 13.50640  1.000 63.67753 ? 70  ALA A C   1 
ATOM   536  O O   . ALA A 1 68  ? 0.76042  -21.93146 13.50419  1.000 68.02901 ? 70  ALA A O   1 
ATOM   537  C CB  . ALA A 1 68  ? 3.55106  -21.62462 12.85412  1.000 52.93242 ? 70  ALA A CB  1 
ATOM   538  N N   . GLY A 1 69  ? 0.57661  -19.69449 13.30056  1.000 68.01751 ? 71  GLY A N   1 
ATOM   539  C CA  . GLY A 1 69  ? -0.86759 -19.71087 13.20916  1.000 67.68698 ? 71  GLY A CA  1 
ATOM   540  C C   . GLY A 1 69  ? -1.44602 -20.11664 14.54125  1.000 73.10075 ? 71  GLY A C   1 
ATOM   541  O O   . GLY A 1 69  ? -1.53505 -19.29704 15.46065  1.000 77.18518 ? 71  GLY A O   1 
ATOM   542  N N   . ASN A 1 70  ? -1.83400 -21.38356 14.65896  1.000 72.20008 ? 72  ASN A N   1 
ATOM   543  C CA  . ASN A 1 70  ? -2.19069 -21.96324 15.94131  1.000 74.52125 ? 72  ASN A CA  1 
ATOM   544  C C   . ASN A 1 70  ? -1.37653 -23.21621 16.24476  1.000 77.53868 ? 72  ASN A C   1 
ATOM   545  O O   . ASN A 1 70  ? -1.54401 -23.79825 17.32441  1.000 82.64091 ? 72  ASN A O   1 
ATOM   546  C CB  . ASN A 1 70  ? -3.69752 -22.26860 15.99957  1.000 69.69231 ? 72  ASN A CB  1 
ATOM   547  C CG  . ASN A 1 70  ? -4.09612 -23.41618 15.09011  1.000 79.27058 ? 72  ASN A CG  1 
ATOM   548  O OD1 . ASN A 1 70  ? -3.94020 -23.33759 13.87215  1.000 75.17696 ? 72  ASN A OD1 1 
ATOM   549  N ND2 . ASN A 1 70  ? -4.61135 -24.49274 15.67936  1.000 82.62250 ? 72  ASN A ND2 1 
ATOM   550  N N   . VAL A 1 71  ? -0.50532 -23.65119 15.32325  1.000 73.56555 ? 73  VAL A N   1 
ATOM   551  C CA  . VAL A 1 71  ? 0.47521  -24.69407 15.62726  1.000 70.70388 ? 73  VAL A CA  1 
ATOM   552  C C   . VAL A 1 71  ? 1.51745  -24.14196 16.59094  1.000 74.52302 ? 73  VAL A C   1 
ATOM   553  O O   . VAL A 1 71  ? 1.89611  -22.96498 16.52073  1.000 74.40830 ? 73  VAL A O   1 
ATOM   554  C CB  . VAL A 1 71  ? 1.15576  -25.20324 14.34278  1.000 65.74489 ? 73  VAL A CB  1 
ATOM   555  C CG1 . VAL A 1 71  ? 2.37877  -26.05062 14.66635  1.000 57.75866 ? 73  VAL A CG1 1 
ATOM   556  C CG2 . VAL A 1 71  ? 0.20593  -25.99142 13.54011  1.000 65.76342 ? 73  VAL A CG2 1 
ATOM   557  N N   . GLN A 1 72  ? 2.00647  -24.98839 17.49384  1.000 68.66116 ? 74  GLN A N   1 
ATOM   558  C CA  . GLN A 1 72  ? 3.09415  -24.60056 18.37810  1.000 67.01921 ? 74  GLN A CA  1 
ATOM   559  C C   . GLN A 1 72  ? 4.37904  -25.25815 17.91089  1.000 69.07442 ? 74  GLN A C   1 
ATOM   560  O O   . GLN A 1 72  ? 4.39538  -26.45932 17.61910  1.000 70.50142 ? 74  GLN A O   1 
ATOM   561  C CB  . GLN A 1 72  ? 2.78041  -24.94986 19.83219  1.000 72.23623 ? 74  GLN A CB  1 
ATOM   562  C CG  . GLN A 1 72  ? 1.86712  -23.89702 20.46356  1.000 78.05780 ? 74  GLN A CG  1 
ATOM   563  C CD  . GLN A 1 72  ? 1.77206  -23.97908 21.97075  1.000 81.38913 ? 74  GLN A CD  1 
ATOM   564  O OE1 . GLN A 1 72  ? 1.16878  -23.12097 22.62126  1.000 89.62259 ? 74  GLN A OE1 1 
ATOM   565  N NE2 . GLN A 1 72  ? 2.33146  -25.03333 22.53238  1.000 79.03044 ? 74  GLN A NE2 1 
ATOM   566  N N   . LEU A 1 73  ? 5.44193  -24.46110 17.82456  1.000 65.46693 ? 75  LEU A N   1 
ATOM   567  C CA  . LEU A 1 73  ? 6.72765  -24.91134 17.31628  1.000 67.55070 ? 75  LEU A CA  1 
ATOM   568  C C   . LEU A 1 73  ? 7.62397  -25.32437 18.47627  1.000 68.53876 ? 75  LEU A C   1 
ATOM   569  O O   . LEU A 1 73  ? 7.56786  -24.74164 19.56333  1.000 66.86136 ? 75  LEU A O   1 
ATOM   570  C CB  . LEU A 1 73  ? 7.40491  -23.79971 16.50752  1.000 64.18625 ? 75  LEU A CB  1 
ATOM   571  C CG  . LEU A 1 73  ? 7.21538  -23.66770 14.98667  1.000 61.70262 ? 75  LEU A CG  1 
ATOM   572  C CD1 . LEU A 1 73  ? 8.06728  -24.66908 14.20704  1.000 61.47141 ? 75  LEU A CD1 1 
ATOM   573  C CD2 . LEU A 1 73  ? 5.75579  -23.80650 14.62983  1.000 61.50386 ? 75  LEU A CD2 1 
ATOM   574  N N   . ARG A 1 74  ? 8.46507  -26.32945 18.23817  1.000 63.81775 ? 76  ARG A N   1 
ATOM   575  C CA  . ARG A 1 74  ? 9.35224  -26.85679 19.27220  1.000 64.50552 ? 76  ARG A CA  1 
ATOM   576  C C   . ARG A 1 74  ? 10.72830 -26.20772 19.13247  1.000 62.97225 ? 76  ARG A C   1 
ATOM   577  O O   . ARG A 1 74  ? 11.44186 -26.45228 18.14993  1.000 57.50956 ? 76  ARG A O   1 
ATOM   578  C CB  . ARG A 1 74  ? 9.44024  -28.37898 19.17749  1.000 63.95623 ? 76  ARG A CB  1 
ATOM   579  C CG  . ARG A 1 74  ? 10.40233 -29.03529 20.16159  1.000 65.94731 ? 76  ARG A CG  1 
ATOM   580  C CD  . ARG A 1 74  ? 9.93892  -28.93275 21.61535  1.000 68.35791 ? 76  ARG A CD  1 
ATOM   581  N NE  . ARG A 1 74  ? 8.83758  -29.83818 21.95232  1.000 70.17244 ? 76  ARG A NE  1 
ATOM   582  C CZ  . ARG A 1 74  ? 8.99870  -31.04334 22.49042  1.000 69.66791 ? 76  ARG A CZ  1 
ATOM   583  N NH1 . ARG A 1 74  ? 10.21632 -31.50272 22.73812  1.000 70.45546 ? 76  ARG A NH1 1 
ATOM   584  N NH2 . ARG A 1 74  ? 7.94233  -31.79317 22.77540  1.000 70.68719 ? 76  ARG A NH2 1 
ATOM   585  N N   . VAL A 1 75  ? 11.09887 -25.38770 20.11676  1.000 57.46503 ? 77  VAL A N   1 
ATOM   586  C CA  . VAL A 1 75  ? 12.37838 -24.68560 20.08695  1.000 54.91517 ? 77  VAL A CA  1 
ATOM   587  C C   . VAL A 1 75  ? 13.46196 -25.62677 20.59448  1.000 59.79882 ? 77  VAL A C   1 
ATOM   588  O O   . VAL A 1 75  ? 13.45304 -26.01671 21.76459  1.000 65.43191 ? 77  VAL A O   1 
ATOM   589  C CB  . VAL A 1 75  ? 12.32810 -23.39651 20.91966  1.000 55.41403 ? 77  VAL A CB  1 
ATOM   590  C CG1 . VAL A 1 75  ? 13.63902 -22.62574 20.78630  1.000 54.50202 ? 77  VAL A CG1 1 
ATOM   591  C CG2 . VAL A 1 75  ? 11.15534 -22.52703 20.49691  1.000 51.27071 ? 77  VAL A CG2 1 
ATOM   592  N N   . ILE A 1 76  ? 14.40021 -25.99150 19.71805  1.000 55.57067 ? 78  ILE A N   1 
ATOM   593  C CA  . ILE A 1 76  ? 15.47410 -26.91813 20.05442  1.000 55.99606 ? 78  ILE A CA  1 
ATOM   594  C C   . ILE A 1 76  ? 16.82888 -26.21938 20.13897  1.000 62.76769 ? 78  ILE A C   1 
ATOM   595  O O   . ILE A 1 76  ? 17.87208 -26.88952 20.17779  1.000 60.92456 ? 78  ILE A O   1 
ATOM   596  C CB  . ILE A 1 76  ? 15.52643 -28.09402 19.06179  1.000 63.06699 ? 78  ILE A CB  1 
ATOM   597  C CG1 . ILE A 1 76  ? 16.02136 -27.63174 17.68245  1.000 57.02013 ? 78  ILE A CG1 1 
ATOM   598  C CG2 . ILE A 1 76  ? 14.15649 -28.80195 18.98071  1.000 59.90848 ? 78  ILE A CG2 1 
ATOM   599  C CD1 . ILE A 1 76  ? 16.07169 -28.75182 16.62417  1.000 56.00962 ? 78  ILE A CD1 1 
ATOM   600  N N   . GLY A 1 77  ? 16.84216 -24.88841 20.18787  1.000 61.17141 ? 79  GLY A N   1 
ATOM   601  C CA  . GLY A 1 77  ? 18.07132 -24.11557 20.16002  1.000 57.60595 ? 79  GLY A CA  1 
ATOM   602  C C   . GLY A 1 77  ? 17.79424 -22.62570 20.16891  1.000 58.56020 ? 79  GLY A C   1 
ATOM   603  O O   . GLY A 1 77  ? 16.74194 -22.18280 19.69549  1.000 58.43090 ? 79  GLY A O   1 
ATOM   604  N N   . HIS A 1 78  ? 18.71413 -21.83929 20.72054  1.000 56.09343 ? 80  HIS A N   1 
ATOM   605  C CA  . HIS A 1 78  ? 18.54004 -20.39664 20.75676  1.000 53.79527 ? 80  HIS A CA  1 
ATOM   606  C C   . HIS A 1 78  ? 19.90622 -19.74345 20.82575  1.000 55.44843 ? 80  HIS A C   1 
ATOM   607  O O   . HIS A 1 78  ? 20.75128 -20.15214 21.62240  1.000 57.96773 ? 80  HIS A O   1 
ATOM   608  C CB  . HIS A 1 78  ? 17.67193 -19.95729 21.94053  1.000 58.52248 ? 80  HIS A CB  1 
ATOM   609  C CG  . HIS A 1 78  ? 18.30531 -20.18228 23.27731  1.000 64.96662 ? 80  HIS A CG  1 
ATOM   610  N ND1 . HIS A 1 78  ? 18.11330 -21.33753 24.00706  1.000 67.09349 ? 80  HIS A ND1 1 
ATOM   611  C CD2 . HIS A 1 78  ? 19.11831 -19.39655 24.02369  1.000 60.96238 ? 80  HIS A CD2 1 
ATOM   612  C CE1 . HIS A 1 78  ? 18.79383 -21.25883 25.13809  1.000 66.26686 ? 80  HIS A CE1 1 
ATOM   613  N NE2 . HIS A 1 78  ? 19.41265 -20.09186 25.17261  1.000 62.56719 ? 80  HIS A NE2 1 
ATOM   614  N N   . SER A 1 79  ? 20.12434 -18.74649 19.97683  1.000 49.27202 ? 81  SER A N   1 
ATOM   615  C CA  . SER A 1 79  ? 21.37124 -18.01024 19.99158  1.000 46.73747 ? 81  SER A CA  1 
ATOM   616  C C   . SER A 1 79  ? 21.09262 -16.57595 19.57270  1.000 52.49286 ? 81  SER A C   1 
ATOM   617  O O   . SER A 1 79  ? 19.98850 -16.23033 19.13640  1.000 47.60275 ? 81  SER A O   1 
ATOM   618  C CB  . SER A 1 79  ? 22.41971 -18.65703 19.09367  1.000 43.73381 ? 81  SER A CB  1 
ATOM   619  O OG  . SER A 1 79  ? 22.07934 -18.55282 17.72765  1.000 53.14689 ? 81  SER A OG  1 
ATOM   620  N N   . MET A 1 80  ? 22.11632 -15.74045 19.70477  1.000 48.03738 ? 82  MET A N   1 
ATOM   621  C CA  . MET A 1 80  ? 21.98051 -14.30661 19.52420  1.000 46.29784 ? 82  MET A CA  1 
ATOM   622  C C   . MET A 1 80  ? 22.95709 -13.85928 18.45382  1.000 45.10735 ? 82  MET A C   1 
ATOM   623  O O   . MET A 1 80  ? 24.16424 -14.06686 18.59467  1.000 49.21060 ? 82  MET A O   1 
ATOM   624  C CB  . MET A 1 80  ? 22.25143 -13.57920 20.83682  1.000 45.58314 ? 82  MET A CB  1 
ATOM   625  C CG  . MET A 1 80  ? 22.03001 -12.09235 20.77158  1.000 44.85982 ? 82  MET A CG  1 
ATOM   626  S SD  . MET A 1 80  ? 22.14150 -11.42192 22.43330  1.000 51.47359 ? 82  MET A SD  1 
ATOM   627  C CE  . MET A 1 80  ? 23.84686 -11.81232 22.86628  1.000 49.36469 ? 82  MET A CE  1 
ATOM   628  N N   . GLN A 1 81  ? 22.44198 -13.25124 17.39107  1.000 40.83036 ? 83  GLN A N   1 
ATOM   629  C CA  . GLN A 1 81  ? 23.27941 -12.64252 16.36657  1.000 40.54153 ? 83  GLN A CA  1 
ATOM   630  C C   . GLN A 1 81  ? 23.01439 -11.14718 16.39869  1.000 41.01583 ? 83  GLN A C   1 
ATOM   631  O O   . GLN A 1 81  ? 21.93506 -10.69645 16.00493  1.000 39.43353 ? 83  GLN A O   1 
ATOM   632  C CB  . GLN A 1 81  ? 23.00626 -13.21925 14.98171  1.000 41.67576 ? 83  GLN A CB  1 
ATOM   633  C CG  . GLN A 1 81  ? 24.07557 -12.79769 13.97932  1.000 49.40294 ? 83  GLN A CG  1 
ATOM   634  C CD  . GLN A 1 81  ? 23.70806 -13.08004 12.52394  1.000 54.07002 ? 83  GLN A CD  1 
ATOM   635  O OE1 . GLN A 1 81  ? 22.61057 -13.56419 12.22812  1.000 57.10741 ? 83  GLN A OE1 1 
ATOM   636  N NE2 . GLN A 1 81  ? 24.63124 -12.76171 11.60299  1.000 52.10403 ? 83  GLN A NE2 1 
ATOM   637  N N   . ASN A 1 82  ? 23.99097 -10.38821 16.88846  1.000 39.66642 ? 84  ASN A N   1 
ATOM   638  C CA  . ASN A 1 82  ? 23.84418 -8.95808  17.09017  1.000 36.88931 ? 84  ASN A CA  1 
ATOM   639  C C   . ASN A 1 82  ? 22.55175 -8.67765  17.85412  1.000 39.09154 ? 84  ASN A C   1 
ATOM   640  O O   . ASN A 1 82  ? 22.41070 -9.14926  18.98846  1.000 35.33171 ? 84  ASN A O   1 
ATOM   641  C CB  . ASN A 1 82  ? 23.93982 -8.27508  15.73696  1.000 38.34349 ? 84  ASN A CB  1 
ATOM   642  C CG  . ASN A 1 82  ? 25.20312 -8.67598  15.00333  1.000 40.45566 ? 84  ASN A CG  1 
ATOM   643  O OD1 . ASN A 1 82  ? 26.29901 -8.38250  15.46472  1.000 41.22297 ? 84  ASN A OD1 1 
ATOM   644  N ND2 . ASN A 1 82  ? 25.06087 -9.40314  13.88942  1.000 42.46567 ? 84  ASN A ND2 1 
ATOM   645  N N   . CYS A 1 83  ? 21.58716 -7.96226  17.26366  1.000 34.64342 ? 85  CYS A N   1 
ATOM   646  C CA  . CYS A 1 83  ? 20.34550 -7.67185  17.97503  1.000 37.06737 ? 85  CYS A CA  1 
ATOM   647  C C   . CYS A 1 83  ? 19.22513 -8.64720  17.63267  1.000 37.23808 ? 85  CYS A C   1 
ATOM   648  O O   . CYS A 1 83  ? 18.07551 -8.43855  18.02300  1.000 35.27898 ? 85  CYS A O   1 
ATOM   649  C CB  . CYS A 1 83  ? 19.93058 -6.22645  17.72256  1.000 36.78885 ? 85  CYS A CB  1 
ATOM   650  S SG  . CYS A 1 83  ? 21.14765 -5.13477  18.50167  1.000 40.98328 ? 85  CYS A SG  1 
ATOM   651  N N   . VAL A 1 84  ? 19.53933 -9.73445  16.96069  1.000 32.80455 ? 86  VAL A N   1 
ATOM   652  C CA  . VAL A 1 84  ? 18.52609 -10.67291 16.53008  1.000 41.02401 ? 86  VAL A CA  1 
ATOM   653  C C   . VAL A 1 84  ? 18.72670 -11.96402 17.29104  1.000 39.87439 ? 86  VAL A C   1 
ATOM   654  O O   . VAL A 1 84  ? 19.86244 -12.43169 17.45734  1.000 39.43769 ? 86  VAL A O   1 
ATOM   655  C CB  . VAL A 1 84  ? 18.57215 -10.90299 15.01029  1.000 38.02871 ? 86  VAL A CB  1 
ATOM   656  C CG1 . VAL A 1 84  ? 18.05705 -12.27771 14.66737  1.000 39.41367 ? 86  VAL A CG1 1 
ATOM   657  C CG2 . VAL A 1 84  ? 17.72543 -9.87054  14.34994  1.000 37.88121 ? 86  VAL A CG2 1 
ATOM   658  N N   . LEU A 1 85  ? 17.62288 -12.52426 17.76473  1.000 42.61478 ? 87  LEU A N   1 
ATOM   659  C CA  . LEU A 1 85  ? 17.61885 -13.86661 18.30552  1.000 41.12895 ? 87  LEU A CA  1 
ATOM   660  C C   . LEU A 1 85  ? 17.25722 -14.86098 17.21536  1.000 45.20843 ? 87  LEU A C   1 
ATOM   661  O O   . LEU A 1 85  ? 16.29145 -14.66057 16.47601  1.000 46.94334 ? 87  LEU A O   1 
ATOM   662  C CB  . LEU A 1 85  ? 16.62700 -13.95433 19.45211  1.000 43.19402 ? 87  LEU A CB  1 
ATOM   663  C CG  . LEU A 1 85  ? 17.14251 -14.91110 20.50396  1.000 50.36717 ? 87  LEU A CG  1 
ATOM   664  C CD1 . LEU A 1 85  ? 18.25347 -14.14279 21.24463  1.000 49.45948 ? 87  LEU A CD1 1 
ATOM   665  C CD2 . LEU A 1 85  ? 15.97916 -15.33214 21.39406  1.000 47.35287 ? 87  LEU A CD2 1 
ATOM   666  N N   . LYS A 1 86  ? 18.04547 -15.92589 17.09709  1.000 46.51068 ? 88  LYS A N   1 
ATOM   667  C CA  . LYS A 1 86  ? 17.72833 -17.02891 16.20220  1.000 42.18953 ? 88  LYS A CA  1 
ATOM   668  C C   . LYS A 1 86  ? 17.25219 -18.22388 17.03344  1.000 48.07002 ? 88  LYS A C   1 
ATOM   669  O O   . LYS A 1 86  ? 18.03958 -18.85119 17.74786  1.000 51.05182 ? 88  LYS A O   1 
ATOM   670  C CB  . LYS A 1 86  ? 18.94009 -17.36801 15.34122  1.000 43.68758 ? 88  LYS A CB  1 
ATOM   671  C CG  . LYS A 1 86  ? 19.69328 -16.12869 14.83888  1.000 49.50294 ? 88  LYS A CG  1 
ATOM   672  C CD  . LYS A 1 86  ? 20.38738 -16.32694 13.48458  1.000 45.53000 ? 88  LYS A CD  1 
ATOM   673  C CE  . LYS A 1 86  ? 21.90012 -16.43016 13.67478  1.000 56.30020 ? 88  LYS A CE  1 
ATOM   674  N NZ  . LYS A 1 86  ? 22.66552 -16.81367 12.45539  1.000 49.94087 ? 88  LYS A NZ  1 
ATOM   675  N N   . LEU A 1 87  ? 15.96735 -18.54949 16.90833  1.000 48.76105 ? 89  LEU A N   1 
ATOM   676  C CA  . LEU A 1 87  ? 15.33203 -19.68171 17.57837  1.000 45.56759 ? 89  LEU A CA  1 
ATOM   677  C C   . LEU A 1 87  ? 15.26411 -20.87558 16.62352  1.000 53.40778 ? 89  LEU A C   1 
ATOM   678  O O   . LEU A 1 87  ? 14.44693 -20.89294 15.69168  1.000 51.79983 ? 89  LEU A O   1 
ATOM   679  C CB  . LEU A 1 87  ? 13.93591 -19.28322 18.03238  1.000 41.33575 ? 89  LEU A CB  1 
ATOM   680  C CG  . LEU A 1 87  ? 13.87881 -18.13923 19.03318  1.000 49.71766 ? 89  LEU A CG  1 
ATOM   681  C CD1 . LEU A 1 87  ? 12.46411 -18.03029 19.60238  1.000 47.80561 ? 89  LEU A CD1 1 
ATOM   682  C CD2 . LEU A 1 87  ? 14.89831 -18.34482 20.15355  1.000 50.00245 ? 89  LEU A CD2 1 
ATOM   683  N N   . LYS A 1 88  ? 16.11142 -21.87896 16.84856  1.000 54.09666 ? 90  LYS A N   1 
ATOM   684  C CA  . LYS A 1 88  ? 16.06213 -23.06627 16.00370  1.000 53.18126 ? 90  LYS A CA  1 
ATOM   685  C C   . LYS A 1 88  ? 14.88157 -23.92872 16.42162  1.000 56.79239 ? 90  LYS A C   1 
ATOM   686  O O   . LYS A 1 88  ? 14.73607 -24.27158 17.59477  1.000 59.84148 ? 90  LYS A O   1 
ATOM   687  C CB  . LYS A 1 88  ? 17.35435 -23.87101 16.07024  1.000 47.16680 ? 90  LYS A CB  1 
ATOM   688  C CG  . LYS A 1 88  ? 17.61514 -24.57678 14.75179  1.000 58.88960 ? 90  LYS A CG  1 
ATOM   689  C CD  . LYS A 1 88  ? 18.36878 -25.87287 14.90762  1.000 58.16492 ? 90  LYS A CD  1 
ATOM   690  C CE  . LYS A 1 88  ? 19.23845 -26.11403 13.70088  1.000 59.85380 ? 90  LYS A CE  1 
ATOM   691  N NZ  . LYS A 1 88  ? 19.67136 -27.52659 13.62440  1.000 58.04191 ? 90  LYS A NZ  1 
ATOM   692  N N   . VAL A 1 89  ? 14.01720 -24.25340 15.46708  1.000 57.47226 ? 91  VAL A N   1 
ATOM   693  C CA  . VAL A 1 89  ? 12.83718 -25.06112 15.73409  1.000 56.45964 ? 91  VAL A CA  1 
ATOM   694  C C   . VAL A 1 89  ? 12.96891 -26.37943 14.96456  1.000 55.71094 ? 91  VAL A C   1 
ATOM   695  O O   . VAL A 1 89  ? 13.83474 -26.53393 14.10521  1.000 56.76253 ? 91  VAL A O   1 
ATOM   696  C CB  . VAL A 1 89  ? 11.54047 -24.31299 15.37548  1.000 56.41309 ? 91  VAL A CB  1 
ATOM   697  C CG1 . VAL A 1 89  ? 11.42535 -23.06636 16.21259  1.000 51.07210 ? 91  VAL A CG1 1 
ATOM   698  C CG2 . VAL A 1 89  ? 11.52499 -23.95338 13.89851  1.000 54.02489 ? 91  VAL A CG2 1 
ATOM   699  N N   . ASP A 1 90  ? 12.10667 -27.34515 15.29010  1.000 57.61845 ? 92  ASP A N   1 
ATOM   700  C CA  . ASP A 1 90  ? 12.27070 -28.67792 14.70771  1.000 62.33290 ? 92  ASP A CA  1 
ATOM   701  C C   . ASP A 1 90  ? 11.55541 -28.86609 13.37216  1.000 60.80585 ? 92  ASP A C   1 
ATOM   702  O O   . ASP A 1 90  ? 11.91403 -29.77839 12.61910  1.000 64.91834 ? 92  ASP A O   1 
ATOM   703  C CB  . ASP A 1 90  ? 11.80624 -29.75208 15.69478  1.000 62.49220 ? 92  ASP A CB  1 
ATOM   704  C CG  . ASP A 1 90  ? 10.34276 -29.64931 16.01577  1.000 67.37653 ? 92  ASP A CG  1 
ATOM   705  O OD1 . ASP A 1 90  ? 9.68423  -28.70604 15.52185  1.000 69.39476 ? 92  ASP A OD1 1 
ATOM   706  O OD2 . ASP A 1 90  ? 9.84969  -30.51166 16.77609  1.000 69.84291 ? 92  ASP A OD2 1 
ATOM   707  N N   . THR A 1 91  ? 10.56574 -28.03783 13.05515  1.000 61.50865 ? 93  THR A N   1 
ATOM   708  C CA  . THR A 1 91  ? 9.95279  -28.02583 11.73143  1.000 60.04096 ? 93  THR A CA  1 
ATOM   709  C C   . THR A 1 91  ? 10.64050 -26.99454 10.84381  1.000 58.13786 ? 93  THR A C   1 
ATOM   710  O O   . THR A 1 91  ? 10.94835 -25.88253 11.28889  1.000 57.54173 ? 93  THR A O   1 
ATOM   711  C CB  . THR A 1 91  ? 8.46224  -27.68294 11.80493  1.000 61.91206 ? 93  THR A CB  1 
ATOM   712  O OG1 . THR A 1 91  ? 7.84002  -28.42147 12.86002  1.000 68.10291 ? 93  THR A OG1 1 
ATOM   713  C CG2 . THR A 1 91  ? 7.77056  -28.01963 10.47964  1.000 58.37898 ? 93  THR A CG2 1 
ATOM   714  N N   . ALA A 1 92  ? 10.88674 -27.36720 9.59070   1.000 53.46702 ? 94  ALA A N   1 
ATOM   715  C CA  . ALA A 1 92  ? 11.19400 -26.37636 8.57565   1.000 50.84031 ? 94  ALA A CA  1 
ATOM   716  C C   . ALA A 1 92  ? 9.87689  -25.85374 8.01560   1.000 56.58762 ? 94  ALA A C   1 
ATOM   717  O O   . ALA A 1 92  ? 8.95668  -26.63278 7.75268   1.000 57.88936 ? 94  ALA A O   1 
ATOM   718  C CB  . ALA A 1 92  ? 12.05909 -26.96267 7.46476   1.000 44.60051 ? 94  ALA A CB  1 
ATOM   719  N N   . ASN A 1 93  ? 9.76789  -24.53685 7.89014   1.000 54.57925 ? 95  ASN A N   1 
ATOM   720  C CA  . ASN A 1 93  ? 8.57892  -23.91856 7.33883   1.000 50.73924 ? 95  ASN A CA  1 
ATOM   721  C C   . ASN A 1 93  ? 8.30066  -24.52156 5.96525   1.000 50.98839 ? 95  ASN A C   1 
ATOM   722  O O   . ASN A 1 93  ? 9.15552  -24.42269 5.07409   1.000 51.10819 ? 95  ASN A O   1 
ATOM   723  C CB  . ASN A 1 93  ? 8.77364  -22.40333 7.24137   1.000 50.11124 ? 95  ASN A CB  1 
ATOM   724  C CG  . ASN A 1 93  ? 7.45403  -21.62381 7.06865   1.000 52.13948 ? 95  ASN A CG  1 
ATOM   725  O OD1 . ASN A 1 93  ? 6.38693  -22.18228 6.77420   1.000 51.36988 ? 95  ASN A OD1 1 
ATOM   726  N ND2 . ASN A 1 93  ? 7.53890  -20.31490 7.25523   1.000 50.31099 ? 95  ASN A ND2 1 
ATOM   727  N N   . PRO A 1 94  ? 7.16103  -25.19530 5.77669   1.000 48.83898 ? 96  PRO A N   1 
ATOM   728  C CA  . PRO A 1 94  ? 6.83395  -25.68438 4.42997   1.000 51.65570 ? 96  PRO A CA  1 
ATOM   729  C C   . PRO A 1 94  ? 6.67207  -24.55594 3.42691   1.000 51.06392 ? 96  PRO A C   1 
ATOM   730  O O   . PRO A 1 94  ? 6.99074  -24.74190 2.24657   1.000 47.87060 ? 96  PRO A O   1 
ATOM   731  C CB  . PRO A 1 94  ? 5.51993  -26.45433 4.64076   1.000 51.78449 ? 96  PRO A CB  1 
ATOM   732  C CG  . PRO A 1 94  ? 4.92799  -25.88573 5.88673   1.000 51.23134 ? 96  PRO A CG  1 
ATOM   733  C CD  . PRO A 1 94  ? 6.08832  -25.47079 6.75048   1.000 49.73420 ? 96  PRO A CD  1 
ATOM   734  N N   . LYS A 1 95  ? 6.21114  -23.38188 3.87316   1.000 50.12881 ? 97  LYS A N   1 
ATOM   735  C CA  . LYS A 1 95  ? 5.98472  -22.22196 3.01862   1.000 53.02106 ? 97  LYS A CA  1 
ATOM   736  C C   . LYS A 1 95  ? 7.20599  -21.32042 2.89353   1.000 49.30463 ? 97  LYS A C   1 
ATOM   737  O O   . LYS A 1 95  ? 7.04362  -20.13469 2.61291   1.000 54.46809 ? 97  LYS A O   1 
ATOM   738  C CB  . LYS A 1 95  ? 4.80505  -21.39141 3.54147   1.000 50.15530 ? 97  LYS A CB  1 
ATOM   739  C CG  . LYS A 1 95  ? 3.58348  -22.20102 3.97768   1.000 55.67691 ? 97  LYS A CG  1 
ATOM   740  C CD  . LYS A 1 95  ? 2.27183  -21.44777 3.72655   1.000 55.58668 ? 97  LYS A CD  1 
ATOM   741  C CE  . LYS A 1 95  ? 1.26396  -21.67957 4.84500   1.000 61.00572 ? 97  LYS A CE  1 
ATOM   742  N NZ  . LYS A 1 95  ? 1.78037  -21.24941 6.19187   1.000 67.69499 ? 97  LYS A NZ  1 
ATOM   743  N N   . THR A 1 96  ? 8.41176  -21.83227 3.12118   1.000 52.49334 ? 98  THR A N   1 
ATOM   744  C CA  . THR A 1 96  ? 9.59536  -20.98815 2.99542   1.000 46.42013 ? 98  THR A CA  1 
ATOM   745  C C   . THR A 1 96  ? 9.80740  -20.65060 1.52630   1.000 49.18749 ? 98  THR A C   1 
ATOM   746  O O   . THR A 1 96  ? 9.84763  -21.55794 0.69260   1.000 52.01200 ? 98  THR A O   1 
ATOM   747  C CB  . THR A 1 96  ? 10.85232 -21.66367 3.54248   1.000 44.24686 ? 98  THR A CB  1 
ATOM   748  O OG1 . THR A 1 96  ? 10.69811 -21.94211 4.93449   1.000 48.68101 ? 98  THR A OG1 1 
ATOM   749  C CG2 . THR A 1 96  ? 12.06421 -20.75574 3.35514   1.000 47.60084 ? 98  THR A CG2 1 
ATOM   750  N N   . PRO A 1 97  ? 9.94136  -19.37842 1.17953   1.000 50.58520 ? 99  PRO A N   1 
ATOM   751  C CA  . PRO A 1 97  ? 10.21447 -18.99708 -0.20935  1.000 46.32099 ? 99  PRO A CA  1 
ATOM   752  C C   . PRO A 1 97  ? 11.70782 -18.91038 -0.46068  1.000 45.55256 ? 99  PRO A C   1 
ATOM   753  O O   . PRO A 1 97  ? 12.53121 -18.94749 0.45954   1.000 48.70915 ? 99  PRO A O   1 
ATOM   754  C CB  . PRO A 1 97  ? 9.57832  -17.60621 -0.30195  1.000 47.76053 ? 99  PRO A CB  1 
ATOM   755  C CG  . PRO A 1 97  ? 9.84594  -17.02891 1.07074   1.000 51.64975 ? 99  PRO A CG  1 
ATOM   756  C CD  . PRO A 1 97  ? 9.83840  -18.19963 2.05166   1.000 48.06353 ? 99  PRO A CD  1 
ATOM   757  N N   . LYS A 1 98  ? 12.05046 -18.78106 -1.73724  1.000 47.56541 ? 100 LYS A N   1 
ATOM   758  C CA  . LYS A 1 98  ? 13.39843 -18.35326 -2.08007  1.000 51.72407 ? 100 LYS A CA  1 
ATOM   759  C C   . LYS A 1 98  ? 13.64724 -16.97254 -1.48178  1.000 48.39274 ? 100 LYS A C   1 
ATOM   760  O O   . LYS A 1 98  ? 12.87094 -16.04143 -1.71163  1.000 43.12727 ? 100 LYS A O   1 
ATOM   761  C CB  . LYS A 1 98  ? 13.57351 -18.32838 -3.59932  1.000 53.36094 ? 100 LYS A CB  1 
ATOM   762  C CG  . LYS A 1 98  ? 13.23319 -19.65562 -4.25983  1.000 56.02524 ? 100 LYS A CG  1 
ATOM   763  C CD  . LYS A 1 98  ? 13.49684 -19.65248 -5.75136  1.000 55.85770 ? 100 LYS A CD  1 
ATOM   764  C CE  . LYS A 1 98  ? 13.38353 -21.06750 -6.30157  1.000 66.37058 ? 100 LYS A CE  1 
ATOM   765  N NZ  . LYS A 1 98  ? 13.50245 -21.10829 -7.77955  1.000 72.51963 ? 100 LYS A NZ  1 
ATOM   766  N N   . TYR A 1 99  ? 14.71543 -16.84274 -0.69404  1.000 47.85400 ? 101 TYR A N   1 
ATOM   767  C CA  . TYR A 1 99  ? 14.97641 -15.58837 -0.00021  1.000 44.13434 ? 101 TYR A CA  1 
ATOM   768  C C   . TYR A 1 99  ? 16.47294 -15.34010 0.09059   1.000 44.44242 ? 101 TYR A C   1 
ATOM   769  O O   . TYR A 1 99  ? 17.26531 -16.28040 0.04166   1.000 44.59466 ? 101 TYR A O   1 
ATOM   770  C CB  . TYR A 1 99  ? 14.37237 -15.58660 1.41130   1.000 46.18243 ? 101 TYR A CB  1 
ATOM   771  C CG  . TYR A 1 99  ? 15.13495 -16.46958 2.36395   1.000 44.88134 ? 101 TYR A CG  1 
ATOM   772  C CD1 . TYR A 1 99  ? 14.91340 -17.84364 2.39028   1.000 43.25672 ? 101 TYR A CD1 1 
ATOM   773  C CD2 . TYR A 1 99  ? 16.10377 -15.93755 3.20797   1.000 40.76582 ? 101 TYR A CD2 1 
ATOM   774  C CE1 . TYR A 1 99  ? 15.62110 -18.66167 3.24768   1.000 46.68033 ? 101 TYR A CE1 1 
ATOM   775  C CE2 . TYR A 1 99  ? 16.81628 -16.74965 4.07237   1.000 42.38462 ? 101 TYR A CE2 1 
ATOM   776  C CZ  . TYR A 1 99  ? 16.57206 -18.11008 4.08512   1.000 42.61216 ? 101 TYR A CZ  1 
ATOM   777  O OH  . TYR A 1 99  ? 17.29161 -18.91761 4.92386   1.000 41.36227 ? 101 TYR A OH  1 
ATOM   778  N N   . LYS A 1 100 ? 16.84278 -14.05023 0.20264   1.000 47.60670 ? 102 LYS A N   1 
ATOM   779  C CA  . LYS A 1 100 ? 18.16692 -13.58400 0.61233   1.000 44.29458 ? 102 LYS A CA  1 
ATOM   780  C C   . LYS A 1 100 ? 17.98930 -12.53056 1.70090   1.000 42.28554 ? 102 LYS A C   1 
ATOM   781  O O   . LYS A 1 100 ? 16.91077 -11.96458 1.86673   1.000 40.73968 ? 102 LYS A O   1 
ATOM   782  C CB  . LYS A 1 100 ? 19.00032 -12.93318 -0.52183  1.000 43.40891 ? 102 LYS A CB  1 
ATOM   783  C CG  . LYS A 1 100 ? 18.64672 -13.28946 -1.94059  1.000 55.93310 ? 102 LYS A CG  1 
ATOM   784  C CD  . LYS A 1 100 ? 19.48136 -12.45994 -2.93189  1.000 57.54461 ? 102 LYS A CD  1 
ATOM   785  C CE  . LYS A 1 100 ? 19.32406 -12.97071 -4.37152  1.000 68.23317 ? 102 LYS A CE  1 
ATOM   786  N NZ  . LYS A 1 100 ? 20.60649 -12.97826 -5.16329  1.000 73.32851 ? 102 LYS A NZ  1 
ATOM   787  N N   . PHE A 1 101 ? 19.07594 -12.24047 2.41155   1.000 39.59896 ? 103 PHE A N   1 
ATOM   788  C CA  . PHE A 1 101 ? 19.12821 -11.20069 3.43235   1.000 39.82512 ? 103 PHE A CA  1 
ATOM   789  C C   . PHE A 1 101 ? 19.98373 -10.06543 2.89387   1.000 45.46808 ? 103 PHE A C   1 
ATOM   790  O O   . PHE A 1 101 ? 21.17098 -10.27031 2.62182   1.000 46.15686 ? 103 PHE A O   1 
ATOM   791  C CB  . PHE A 1 101 ? 19.75668 -11.71271 4.72656   1.000 39.56332 ? 103 PHE A CB  1 
ATOM   792  C CG  . PHE A 1 101 ? 18.88348 -12.62469 5.53788   1.000 41.17977 ? 103 PHE A CG  1 
ATOM   793  C CD1 . PHE A 1 101 ? 17.52098 -12.68927 5.33706   1.000 37.96402 ? 103 PHE A CD1 1 
ATOM   794  C CD2 . PHE A 1 101 ? 19.45173 -13.42275 6.52804   1.000 39.66521 ? 103 PHE A CD2 1 
ATOM   795  C CE1 . PHE A 1 101 ? 16.73585 -13.53093 6.11610   1.000 34.33149 ? 103 PHE A CE1 1 
ATOM   796  C CE2 . PHE A 1 101 ? 18.67421 -14.26514 7.29407   1.000 38.23469 ? 103 PHE A CE2 1 
ATOM   797  C CZ  . PHE A 1 101 ? 17.31622 -14.31481 7.09232   1.000 38.12931 ? 103 PHE A CZ  1 
ATOM   798  N N   . VAL A 1 102 ? 19.40988 -8.86798  2.77247   1.000 39.16881 ? 104 VAL A N   1 
ATOM   799  C CA  . VAL A 1 102 ? 20.12340 -7.75149  2.17270   1.000 37.35767 ? 104 VAL A CA  1 
ATOM   800  C C   . VAL A 1 102 ? 20.09592 -6.56874  3.12399   1.000 38.13739 ? 104 VAL A C   1 
ATOM   801  O O   . VAL A 1 102 ? 19.08809 -6.31406  3.78393   1.000 43.18964 ? 104 VAL A O   1 
ATOM   802  C CB  . VAL A 1 102 ? 19.52482 -7.37990  0.79900   1.000 42.89385 ? 104 VAL A CB  1 
ATOM   803  C CG1 . VAL A 1 102 ? 18.01662 -7.26377  0.88628   1.000 38.02179 ? 104 VAL A CG1 1 
ATOM   804  C CG2 . VAL A 1 102 ? 20.14253 -6.08724  0.26389   1.000 43.13007 ? 104 VAL A CG2 1 
ATOM   805  N N   . ARG A 1 103 ? 21.21673 -5.87828  3.22569   1.000 38.57413 ? 105 ARG A N   1 
ATOM   806  C CA  . ARG A 1 103 ? 21.28468 -4.59514  3.89471   1.000 39.97882 ? 105 ARG A CA  1 
ATOM   807  C C   . ARG A 1 103 ? 21.10142 -3.52291  2.82984   1.000 42.05655 ? 105 ARG A C   1 
ATOM   808  O O   . ARG A 1 103 ? 21.88920 -3.45264  1.88092   1.000 43.54300 ? 105 ARG A O   1 
ATOM   809  C CB  . ARG A 1 103 ? 22.61662 -4.43545  4.62923   1.000 38.35068 ? 105 ARG A CB  1 
ATOM   810  C CG  . ARG A 1 103 ? 22.69212 -3.17256  5.46823   1.000 41.52421 ? 105 ARG A CG  1 
ATOM   811  C CD  . ARG A 1 103 ? 23.94992 -3.10184  6.30920   1.000 42.73892 ? 105 ARG A CD  1 
ATOM   812  N NE  . ARG A 1 103 ? 23.93075 -1.93319  7.18942   1.000 46.64985 ? 105 ARG A NE  1 
ATOM   813  C CZ  . ARG A 1 103 ? 23.38496 -1.90213  8.40568   1.000 45.60825 ? 105 ARG A CZ  1 
ATOM   814  N NH1 . ARG A 1 103 ? 22.79834 -2.98106  8.92485   1.000 39.02666 ? 105 ARG A NH1 1 
ATOM   815  N NH2 . ARG A 1 103 ? 23.43100 -0.78028  9.11283   1.000 44.51764 ? 105 ARG A NH2 1 
ATOM   816  N N   . ILE A 1 104 ? 20.03285 -2.72741  2.94830   1.000 41.63013 ? 106 ILE A N   1 
ATOM   817  C CA  . ILE A 1 104 ? 19.74918 -1.68832  1.95873   1.000 39.42093 ? 106 ILE A CA  1 
ATOM   818  C C   . ILE A 1 104 ? 20.45984 -0.41056  2.35913   1.000 40.48592 ? 106 ILE A C   1 
ATOM   819  O O   . ILE A 1 104 ? 20.95820 -0.28738  3.48581   1.000 39.65460 ? 106 ILE A O   1 
ATOM   820  C CB  . ILE A 1 104 ? 18.24433 -1.40276  1.80005   1.000 43.55460 ? 106 ILE A CB  1 
ATOM   821  C CG1 . ILE A 1 104 ? 17.65890 -0.89541  3.13327   1.000 41.18440 ? 106 ILE A CG1 1 
ATOM   822  C CG2 . ILE A 1 104 ? 17.52554 -2.58418  1.21651   1.000 36.37782 ? 106 ILE A CG2 1 
ATOM   823  C CD1 . ILE A 1 104 ? 16.28351 -0.31347  3.01990   1.000 40.17603 ? 106 ILE A CD1 1 
ATOM   824  N N   . GLN A 1 105 ? 20.46631 0.57530   1.43504   1.000 41.35830 ? 107 GLN A N   1 
ATOM   825  C CA  . GLN A 1 105 ? 21.09330 1.88975   1.48021   1.000 44.32744 ? 107 GLN A CA  1 
ATOM   826  C C   . GLN A 1 105 ? 20.07960 2.96455   1.84805   1.000 42.59419 ? 107 GLN A C   1 
ATOM   827  O O   . GLN A 1 105 ? 18.89924 2.86139   1.50117   1.000 41.46991 ? 107 GLN A O   1 
ATOM   828  C CB  . GLN A 1 105 ? 21.70927 2.23800   0.12030   1.000 43.51636 ? 107 GLN A CB  1 
ATOM   829  C CG  . GLN A 1 105 ? 22.88006 1.37125   -0.26779  1.000 46.27978 ? 107 GLN A CG  1 
ATOM   830  C CD  . GLN A 1 105 ? 24.08984 1.65018   0.60517   1.000 56.69316 ? 107 GLN A CD  1 
ATOM   831  O OE1 . GLN A 1 105 ? 24.68230 0.72572   1.16989   1.000 58.58001 ? 107 GLN A OE1 1 
ATOM   832  N NE2 . GLN A 1 105 ? 24.46240 2.93460   0.73017   1.000 50.10057 ? 107 GLN A NE2 1 
ATOM   833  N N   . PRO A 1 106 ? 20.50692 4.02986   2.51581   1.000 41.00137 ? 108 PRO A N   1 
ATOM   834  C CA  . PRO A 1 106 ? 19.60031 5.15963   2.72184   1.000 40.97049 ? 108 PRO A CA  1 
ATOM   835  C C   . PRO A 1 106 ? 19.05117 5.62554   1.38072   1.000 44.64542 ? 108 PRO A C   1 
ATOM   836  O O   . PRO A 1 106 ? 19.76030 5.65621   0.37148   1.000 44.24368 ? 108 PRO A O   1 
ATOM   837  C CB  . PRO A 1 106 ? 20.48417 6.21849   3.39218   1.000 42.05946 ? 108 PRO A CB  1 
ATOM   838  C CG  . PRO A 1 106 ? 21.88198 5.78810   3.16027   1.000 45.02927 ? 108 PRO A CG  1 
ATOM   839  C CD  . PRO A 1 106 ? 21.84793 4.28646   3.06523   1.000 44.49806 ? 108 PRO A CD  1 
ATOM   840  N N   . GLY A 1 107 ? 17.75283 5.92309   1.35540   1.000 40.76122 ? 109 GLY A N   1 
ATOM   841  C CA  . GLY A 1 107 ? 17.07204 6.28305   0.14238   1.000 39.29845 ? 109 GLY A CA  1 
ATOM   842  C C   . GLY A 1 107 ? 16.28490 5.15013   -0.47739  1.000 43.43150 ? 109 GLY A C   1 
ATOM   843  O O   . GLY A 1 107 ? 15.25287 5.40057   -1.09699  1.000 45.58372 ? 109 GLY A O   1 
ATOM   844  N N   . GLN A 1 108 ? 16.73709 3.91122   -0.31548  1.000 46.15299 ? 110 GLN A N   1 
ATOM   845  C CA  . GLN A 1 108 ? 16.05518 2.78984   -0.94130  1.000 43.30654 ? 110 GLN A CA  1 
ATOM   846  C C   . GLN A 1 108 ? 14.76251 2.43317   -0.20026  1.000 43.21080 ? 110 GLN A C   1 
ATOM   847  O O   . GLN A 1 108 ? 14.62155 2.65508   1.00743   1.000 40.95957 ? 110 GLN A O   1 
ATOM   848  C CB  . GLN A 1 108 ? 16.98357 1.57968   -1.00850  1.000 46.19770 ? 110 GLN A CB  1 
ATOM   849  C CG  . GLN A 1 108 ? 17.08747 1.01021   -2.41396  1.000 53.57667 ? 110 GLN A CG  1 
ATOM   850  C CD  . GLN A 1 108 ? 18.28824 0.11629   -2.58308  1.000 58.42851 ? 110 GLN A CD  1 
ATOM   851  O OE1 . GLN A 1 108 ? 19.19253 0.11539   -1.74503  1.000 53.84296 ? 110 GLN A OE1 1 
ATOM   852  N NE2 . GLN A 1 108 ? 18.30505 -0.66357  -3.66690  1.000 67.74387 ? 110 GLN A NE2 1 
ATOM   853  N N   . THR A 1 109 ? 13.81768 1.86116   -0.94378  1.000 40.88226 ? 111 THR A N   1 
ATOM   854  C CA  . THR A 1 109 ? 12.47795 1.58334   -0.45076  1.000 39.79416 ? 111 THR A CA  1 
ATOM   855  C C   . THR A 1 109 ? 12.22580 0.08486   -0.33545  1.000 36.22611 ? 111 THR A C   1 
ATOM   856  O O   . THR A 1 109 ? 12.95994 -0.74965  -0.87786  1.000 36.28867 ? 111 THR A O   1 
ATOM   857  C CB  . THR A 1 109 ? 11.43440 2.22134   -1.37321  1.000 41.77022 ? 111 THR A CB  1 
ATOM   858  O OG1 . THR A 1 109 ? 11.49365 1.59430   -2.66409  1.000 38.63679 ? 111 THR A OG1 1 
ATOM   859  C CG2 . THR A 1 109 ? 11.71665 3.72149   -1.50643  1.000 38.57606 ? 111 THR A CG2 1 
ATOM   860  N N   . PHE A 1 110 ? 11.15304 -0.24520  0.37838   1.000 36.22266 ? 112 PHE A N   1 
ATOM   861  C CA  . PHE A 1 110 ? 10.74414 -1.62550  0.58623   1.000 35.60665 ? 112 PHE A CA  1 
ATOM   862  C C   . PHE A 1 110 ? 9.29573  -1.63971  1.05301   1.000 37.92246 ? 112 PHE A C   1 
ATOM   863  O O   . PHE A 1 110 ? 8.74609  -0.60747  1.44602   1.000 35.99582 ? 112 PHE A O   1 
ATOM   864  C CB  . PHE A 1 110 ? 11.65934 -2.33289  1.58620   1.000 33.46773 ? 112 PHE A CB  1 
ATOM   865  C CG  . PHE A 1 110 ? 11.77781 -1.63528  2.90664   1.000 33.01512 ? 112 PHE A CG  1 
ATOM   866  C CD1 . PHE A 1 110 ? 12.75118 -0.67838  3.11038   1.000 36.01243 ? 112 PHE A CD1 1 
ATOM   867  C CD2 . PHE A 1 110 ? 10.93374 -1.96437  3.96037   1.000 33.56335 ? 112 PHE A CD2 1 
ATOM   868  C CE1 . PHE A 1 110 ? 12.86996 -0.02724  4.33649   1.000 37.60898 ? 112 PHE A CE1 1 
ATOM   869  C CE2 . PHE A 1 110 ? 11.04691 -1.32457  5.17577   1.000 35.79535 ? 112 PHE A CE2 1 
ATOM   870  C CZ  . PHE A 1 110 ? 12.02148 -0.34551  5.36355   1.000 32.09423 ? 112 PHE A CZ  1 
ATOM   871  N N   . SER A 1 111 ? 8.66584  -2.81521  0.96990   1.000 35.27204 ? 113 SER A N   1 
ATOM   872  C CA  . SER A 1 111 ? 7.33368  -2.98862  1.53297   1.000 33.57798 ? 113 SER A CA  1 
ATOM   873  C C   . SER A 1 111 ? 7.46387  -3.50784  2.96114   1.000 36.79581 ? 113 SER A C   1 
ATOM   874  O O   . SER A 1 111 ? 8.44621  -4.15947  3.30581   1.000 35.96178 ? 113 SER A O   1 
ATOM   875  C CB  . SER A 1 111 ? 6.49331  -3.96307  0.71080   1.000 37.55168 ? 113 SER A CB  1 
ATOM   876  O OG  . SER A 1 111 ? 6.26871  -3.52185  -0.61764  1.000 40.38940 ? 113 SER A OG  1 
ATOM   877  N N   . VAL A 1 112 ? 6.46001  -3.22136  3.78731   1.000 34.04212 ? 114 VAL A N   1 
ATOM   878  C CA  . VAL A 1 112 ? 6.41985  -3.65908  5.17756   1.000 33.17469 ? 114 VAL A CA  1 
ATOM   879  C C   . VAL A 1 112 ? 5.15455  -4.47545  5.37726   1.000 34.06693 ? 114 VAL A C   1 
ATOM   880  O O   . VAL A 1 112 ? 4.06192  -4.02254  5.02280   1.000 36.33371 ? 114 VAL A O   1 
ATOM   881  C CB  . VAL A 1 112 ? 6.43637  -2.47227  6.15742   1.000 34.52845 ? 114 VAL A CB  1 
ATOM   882  C CG1 . VAL A 1 112 ? 6.24716  -2.96637  7.58084   1.000 27.02690 ? 114 VAL A CG1 1 
ATOM   883  C CG2 . VAL A 1 112 ? 7.71301  -1.66716  6.01197   1.000 36.22686 ? 114 VAL A CG2 1 
ATOM   884  N N   . LEU A 1 113 ? 5.29219  -5.66385  5.95380   1.000 30.72912 ? 115 LEU A N   1 
ATOM   885  C CA  . LEU A 1 113 ? 4.12690  -6.45810  6.31920   1.000 32.75284 ? 115 LEU A CA  1 
ATOM   886  C C   . LEU A 1 113 ? 3.93182  -6.28120  7.82527   1.000 34.01959 ? 115 LEU A C   1 
ATOM   887  O O   . LEU A 1 113 ? 4.53622  -6.97818  8.64669   1.000 34.01338 ? 115 LEU A O   1 
ATOM   888  C CB  . LEU A 1 113 ? 4.30873  -7.91089  5.88594   1.000 31.18514 ? 115 LEU A CB  1 
ATOM   889  C CG  . LEU A 1 113 ? 3.12497  -8.81020  6.23796   1.000 36.70722 ? 115 LEU A CG  1 
ATOM   890  C CD1 . LEU A 1 113 ? 1.87940  -8.47859  5.42570   1.000 38.16373 ? 115 LEU A CD1 1 
ATOM   891  C CD2 . LEU A 1 113 ? 3.52401  -10.28196 6.09968   1.000 35.96178 ? 115 LEU A CD2 1 
ATOM   892  N N   . ALA A 1 114 ? 3.10392  -5.30571  8.19363   1.000 32.74928 ? 116 ALA A N   1 
ATOM   893  C CA  . ALA A 1 114 ? 2.88571  -5.02382  9.60485   1.000 39.52013 ? 116 ALA A CA  1 
ATOM   894  C C   . ALA A 1 114 ? 2.06107  -6.14364  10.23224  1.000 38.51350 ? 116 ALA A C   1 
ATOM   895  O O   . ALA A 1 114 ? 0.93783  -6.42796  9.78925   1.000 40.28263 ? 116 ALA A O   1 
ATOM   896  C CB  . ALA A 1 114 ? 2.20979  -3.66580  9.78935   1.000 36.59418 ? 116 ALA A CB  1 
ATOM   897  N N   . CYS A 1 115 ? 2.63600  -6.78257  11.25218  1.000 37.89379 ? 117 CYS A N   1 
ATOM   898  C CA  . CYS A 1 115 ? 2.04284  -7.91001  11.95692  1.000 39.88845 ? 117 CYS A CA  1 
ATOM   899  C C   . CYS A 1 115 ? 1.88233  -7.59843  13.44073  1.000 41.61534 ? 117 CYS A C   1 
ATOM   900  O O   . CYS A 1 115 ? 2.63663  -6.80694  14.01637  1.000 40.21256 ? 117 CYS A O   1 
ATOM   901  C CB  . CYS A 1 115 ? 2.91103  -9.16164  11.80917  1.000 41.40743 ? 117 CYS A CB  1 
ATOM   902  S SG  . CYS A 1 115 ? 3.16813  -9.68741  10.10060  1.000 45.48321 ? 117 CYS A SG  1 
ATOM   903  N N   . TYR A 1 116 ? 0.90087  -8.25068  14.06315  1.000 46.47675 ? 118 TYR A N   1 
ATOM   904  C CA  . TYR A 1 116 ? 0.75534  -8.28347  15.52051  1.000 45.76900 ? 118 TYR A CA  1 
ATOM   905  C C   . TYR A 1 116 ? 0.35591  -9.70276  15.90947  1.000 48.39942 ? 118 TYR A C   1 
ATOM   906  O O   . TYR A 1 116 ? -0.47736 -10.32137 15.23577  1.000 48.05918 ? 118 TYR A O   1 
ATOM   907  C CB  . TYR A 1 116 ? -0.27559 -7.24019  16.01085  1.000 37.50069 ? 118 TYR A CB  1 
ATOM   908  C CG  . TYR A 1 116 ? 0.03214  -5.85649  15.45107  1.000 44.09389 ? 118 TYR A CG  1 
ATOM   909  C CD1 . TYR A 1 116 ? -0.40965 -5.47341  14.18902  1.000 44.46702 ? 118 TYR A CD1 1 
ATOM   910  C CD2 . TYR A 1 116 ? 0.81319  -4.95536  16.16907  1.000 39.43615 ? 118 TYR A CD2 1 
ATOM   911  C CE1 . TYR A 1 116 ? -0.09247 -4.21862  13.66885  1.000 46.42304 ? 118 TYR A CE1 1 
ATOM   912  C CE2 . TYR A 1 116 ? 1.12690  -3.72825  15.66304  1.000 41.24088 ? 118 TYR A CE2 1 
ATOM   913  C CZ  . TYR A 1 116 ? 0.68246  -3.35979  14.41401  1.000 44.44994 ? 118 TYR A CZ  1 
ATOM   914  O OH  . TYR A 1 116 ? 1.00914  -2.12024  13.93005  1.000 44.94199 ? 118 TYR A OH  1 
ATOM   915  N N   . ASN A 1 117 ? 0.98920  -10.23622 16.95896  1.000 43.71945 ? 119 ASN A N   1 
ATOM   916  C CA  . ASN A 1 117 ? 0.74757  -11.60427 17.41788  1.000 46.00262 ? 119 ASN A CA  1 
ATOM   917  C C   . ASN A 1 117 ? 0.95837  -12.63043 16.31320  1.000 47.33681 ? 119 ASN A C   1 
ATOM   918  O O   . ASN A 1 117 ? 0.27256  -13.65168 16.26416  1.000 49.72113 ? 119 ASN A O   1 
ATOM   919  C CB  . ASN A 1 117 ? -0.64988 -11.75016 18.01253  1.000 44.67741 ? 119 ASN A CB  1 
ATOM   920  C CG  . ASN A 1 117 ? -0.94671 -10.68408 19.03324  1.000 53.95567 ? 119 ASN A CG  1 
ATOM   921  O OD1 . ASN A 1 117 ? -0.13094 -10.41730 19.91269  1.000 55.09373 ? 119 ASN A OD1 1 
ATOM   922  N ND2 . ASN A 1 117 ? -2.10355 -10.03822 18.90497  1.000 57.03140 ? 119 ASN A ND2 1 
ATOM   923  N N   . GLY A 1 118 ? 1.91496  -12.38374 15.42617  1.000 46.48846 ? 120 GLY A N   1 
ATOM   924  C CA  . GLY A 1 118 ? 2.20096  -13.31900 14.36169  1.000 45.38544 ? 120 GLY A CA  1 
ATOM   925  C C   . GLY A 1 118 ? 1.23375  -13.32031 13.19735  1.000 43.93067 ? 120 GLY A C   1 
ATOM   926  O O   . GLY A 1 118 ? 1.46542  -14.06463 12.23592  1.000 51.96158 ? 120 GLY A O   1 
ATOM   927  N N   . SER A 1 119 ? 0.14914  -12.49774 13.23615  1.000 45.21247 ? 121 SER A N   1 
ATOM   928  C CA  . SER A 1 119 ? -0.78569 -12.39019 12.11653  1.000 40.43377 ? 121 SER A CA  1 
ATOM   929  C C   . SER A 1 119 ? -0.58949 -11.08951 11.34802  1.000 45.66201 ? 121 SER A C   1 
ATOM   930  O O   . SER A 1 119 ? -0.49746 -10.01426 11.95486  1.000 44.70507 ? 121 SER A O   1 
ATOM   931  C CB  . SER A 1 119 ? -2.23923 -12.45934 12.59448  1.000 41.65473 ? 121 SER A CB  1 
ATOM   932  O OG  . SER A 1 119 ? -2.47949 -13.66849 13.30150  1.000 50.38093 ? 121 SER A OG  1 
ATOM   933  N N   . PRO A 1 120 ? -0.53671 -11.14177 10.01760  1.000 48.82484 ? 122 PRO A N   1 
ATOM   934  C CA  . PRO A 1 120 ? -0.45398 -9.89754  9.24321   1.000 43.31891 ? 122 PRO A CA  1 
ATOM   935  C C   . PRO A 1 120 ? -1.65680 -8.99792  9.48026   1.000 41.35372 ? 122 PRO A C   1 
ATOM   936  O O   . PRO A 1 120 ? -2.78057 -9.46565  9.64981   1.000 44.94721 ? 122 PRO A O   1 
ATOM   937  C CB  . PRO A 1 120 ? -0.39295 -10.39258 7.79711   1.000 44.58028 ? 122 PRO A CB  1 
ATOM   938  C CG  . PRO A 1 120 ? 0.27889  -11.72908 7.90732   1.000 46.30716 ? 122 PRO A CG  1 
ATOM   939  C CD  . PRO A 1 120 ? -0.27493 -12.32597 9.18124   1.000 51.45913 ? 122 PRO A CD  1 
ATOM   940  N N   . SER A 1 121 ? -1.41762 -7.68879  9.50306   1.000 40.19524 ? 123 SER A N   1 
ATOM   941  C CA  . SER A 1 121 ? -2.52744 -6.75276  9.52247   1.000 42.10537 ? 123 SER A CA  1 
ATOM   942  C C   . SER A 1 121 ? -2.56889 -5.79927  8.32594   1.000 40.88486 ? 123 SER A C   1 
ATOM   943  O O   . SER A 1 121 ? -3.64305 -5.26349  8.03151   1.000 44.42250 ? 123 SER A O   1 
ATOM   944  C CB  . SER A 1 121 ? -2.52272 -5.93878  10.83047  1.000 45.94797 ? 123 SER A CB  1 
ATOM   945  O OG  . SER A 1 121 ? -1.95183 -4.66380  10.67382  1.000 47.68570 ? 123 SER A OG  1 
ATOM   946  N N   . GLY A 1 122 ? -1.46341 -5.59685  7.61983   1.000 37.21223 ? 124 GLY A N   1 
ATOM   947  C CA  . GLY A 1 122 ? -1.43787 -4.63215  6.53110   1.000 36.71711 ? 124 GLY A CA  1 
ATOM   948  C C   . GLY A 1 122 ? -0.06995 -4.59174  5.88388   1.000 38.45477 ? 124 GLY A C   1 
ATOM   949  O O   . GLY A 1 122 ? 0.92662  -5.04230  6.45477   1.000 35.13403 ? 124 GLY A O   1 
ATOM   950  N N   . VAL A 1 123 ? -0.04010 -4.04930  4.66805   1.000 39.37191 ? 125 VAL A N   1 
ATOM   951  C CA  . VAL A 1 123 ? 1.19429  -3.91472  3.90077   1.000 40.20617 ? 125 VAL A CA  1 
ATOM   952  C C   . VAL A 1 123 ? 1.23711  -2.51761  3.29446   1.000 38.22348 ? 125 VAL A C   1 
ATOM   953  O O   . VAL A 1 123 ? 0.21482  -2.01844  2.81107   1.000 39.95105 ? 125 VAL A O   1 
ATOM   954  C CB  . VAL A 1 123 ? 1.30903  -5.02085  2.81882   1.000 41.53352 ? 125 VAL A CB  1 
ATOM   955  C CG1 . VAL A 1 123 ? 0.02638  -5.11284  1.99875   1.000 44.44134 ? 125 VAL A CG1 1 
ATOM   956  C CG2 . VAL A 1 123 ? 2.51931  -4.80334  1.91653   1.000 37.57757 ? 125 VAL A CG2 1 
ATOM   957  N N   . TYR A 1 124 ? 2.40656  -1.86636  3.37023   1.000 36.39101 ? 126 TYR A N   1 
ATOM   958  C CA  . TYR A 1 124 ? 2.60117  -0.52108  2.82823   1.000 38.27003 ? 126 TYR A CA  1 
ATOM   959  C C   . TYR A 1 124 ? 4.05366  -0.32700  2.39663   1.000 34.69533 ? 126 TYR A C   1 
ATOM   960  O O   . TYR A 1 124 ? 4.94146  -1.09569  2.75972   1.000 36.59801 ? 126 TYR A O   1 
ATOM   961  C CB  . TYR A 1 124 ? 2.21117  0.57565   3.83783   1.000 41.89262 ? 126 TYR A CB  1 
ATOM   962  C CG  . TYR A 1 124 ? 2.94850  0.51941   5.17255   1.000 41.26751 ? 126 TYR A CG  1 
ATOM   963  C CD1 . TYR A 1 124 ? 4.19037  1.11219   5.32963   1.000 40.66126 ? 126 TYR A CD1 1 
ATOM   964  C CD2 . TYR A 1 124 ? 2.38772  -0.12154  6.27261   1.000 40.86313 ? 126 TYR A CD2 1 
ATOM   965  C CE1 . TYR A 1 124 ? 4.85513  1.06835   6.54973   1.000 44.35660 ? 126 TYR A CE1 1 
ATOM   966  C CE2 . TYR A 1 124 ? 3.03979  -0.16856  7.49119   1.000 43.08863 ? 126 TYR A CE2 1 
ATOM   967  C CZ  . TYR A 1 124 ? 4.27666  0.42339   7.62482   1.000 44.50573 ? 126 TYR A CZ  1 
ATOM   968  O OH  . TYR A 1 124 ? 4.93113  0.37326   8.83907   1.000 44.28472 ? 126 TYR A OH  1 
ATOM   969  N N   . GLN A 1 125 ? 4.30290  0.74583   1.65233   1.000 41.01750 ? 127 GLN A N   1 
ATOM   970  C CA  . GLN A 1 125 ? 5.64163  1.02923   1.15135   1.000 40.53043 ? 127 GLN A CA  1 
ATOM   971  C C   . GLN A 1 125 ? 6.34476  2.08198   1.98551   1.000 41.60059 ? 127 GLN A C   1 
ATOM   972  O O   . GLN A 1 125 ? 5.76177  3.11146   2.33765   1.000 48.69452 ? 127 GLN A O   1 
ATOM   973  C CB  . GLN A 1 125 ? 5.61511  1.47744   -0.30159  1.000 41.43556 ? 127 GLN A CB  1 
ATOM   974  C CG  . GLN A 1 125 ? 5.72255  0.28005   -1.20147  1.000 49.51661 ? 127 GLN A CG  1 
ATOM   975  C CD  . GLN A 1 125 ? 7.13396  -0.01624  -1.66292  1.000 48.18899 ? 127 GLN A CD  1 
ATOM   976  O OE1 . GLN A 1 125 ? 7.87512  0.88466   -2.06777  1.000 52.19610 ? 127 GLN A OE1 1 
ATOM   977  N NE2 . GLN A 1 125 ? 7.50985  -1.28805  -1.62046  1.000 44.30579 ? 127 GLN A NE2 1 
ATOM   978  N N   . CYS A 1 126 ? 7.61881  1.81920   2.25628   1.000 38.49776 ? 128 CYS A N   1 
ATOM   979  C CA  . CYS A 1 126 ? 8.47753  2.63952   3.08881   1.000 43.28635 ? 128 CYS A CA  1 
ATOM   980  C C   . CYS A 1 126 ? 9.73930  2.97437   2.32463   1.000 42.43240 ? 128 CYS A C   1 
ATOM   981  O O   . CYS A 1 126 ? 10.11676 2.26192   1.39444   1.000 36.36507 ? 128 CYS A O   1 
ATOM   982  C CB  . CYS A 1 126 ? 8.89240  1.90716   4.36968   1.000 39.21728 ? 128 CYS A CB  1 
ATOM   983  S SG  . CYS A 1 126 ? 7.82393  2.27642   5.65283   1.000 60.24690 ? 128 CYS A SG  1 
ATOM   984  N N   . ALA A 1 127 ? 10.41445 4.03743   2.76720   1.000 42.84716 ? 129 ALA A N   1 
ATOM   985  C CA  . ALA A 1 127 ? 11.80085 4.29680   2.40282   1.000 40.14534 ? 129 ALA A CA  1 
ATOM   986  C C   . ALA A 1 127 ? 12.66445 4.30524   3.66163   1.000 43.82018 ? 129 ALA A C   1 
ATOM   987  O O   . ALA A 1 127 ? 12.20982 4.68286   4.74752   1.000 39.77762 ? 129 ALA A O   1 
ATOM   988  C CB  . ALA A 1 127 ? 11.96434 5.63524   1.66144   1.000 37.48228 ? 129 ALA A CB  1 
ATOM   989  N N   . MET A 1 128 ? 13.91589 3.88270   3.51058   1.000 41.00548 ? 130 MET A N   1 
ATOM   990  C CA  . MET A 1 128 ? 14.90694 4.07114   4.55969   1.000 41.07408 ? 130 MET A CA  1 
ATOM   991  C C   . MET A 1 128 ? 15.38638 5.51829   4.49746   1.000 40.84924 ? 130 MET A C   1 
ATOM   992  O O   . MET A 1 128 ? 15.97328 5.93575   3.49217   1.000 41.82864 ? 130 MET A O   1 
ATOM   993  C CB  . MET A 1 128 ? 16.06045 3.08306   4.37314   1.000 39.47718 ? 130 MET A CB  1 
ATOM   994  C CG  . MET A 1 128 ? 17.30071 3.35550   5.22804   1.000 43.51854 ? 130 MET A CG  1 
ATOM   995  S SD  . MET A 1 128 ? 17.07773 2.82260   6.93197   1.000 49.28740 ? 130 MET A SD  1 
ATOM   996  C CE  . MET A 1 128 ? 16.66547 1.09134   6.68581   1.000 43.77408 ? 130 MET A CE  1 
ATOM   997  N N   . ARG A 1 129 ? 15.11027 6.30043   5.54274   1.000 41.59244 ? 131 ARG A N   1 
ATOM   998  C CA  . ARG A 1 129 ? 15.48599 7.70388   5.50537   1.000 36.25606 ? 131 ARG A CA  1 
ATOM   999  C C   . ARG A 1 129 ? 17.00566 7.82589   5.46756   1.000 40.87093 ? 131 ARG A C   1 
ATOM   1000 O O   . ARG A 1 129 ? 17.71651 6.92012   5.91120   1.000 41.66186 ? 131 ARG A O   1 
ATOM   1001 C CB  . ARG A 1 129 ? 14.94407 8.45957   6.71190   1.000 38.82655 ? 131 ARG A CB  1 
ATOM   1002 C CG  . ARG A 1 129 ? 13.43598 8.52391   6.79533   1.000 42.23082 ? 131 ARG A CG  1 
ATOM   1003 C CD  . ARG A 1 129 ? 12.84883 8.92733   5.49316   1.000 41.82490 ? 131 ARG A CD  1 
ATOM   1004 N NE  . ARG A 1 129 ? 13.28708 10.26253  5.11119   1.000 45.58287 ? 131 ARG A NE  1 
ATOM   1005 C CZ  . ARG A 1 129 ? 12.83666 10.88355  4.03527   1.000 42.83088 ? 131 ARG A CZ  1 
ATOM   1006 N NH1 . ARG A 1 129 ? 11.95196 10.25629  3.27100   1.000 40.94870 ? 131 ARG A NH1 1 
ATOM   1007 N NH2 . ARG A 1 129 ? 13.27177 12.09937  3.71978   1.000 42.06793 ? 131 ARG A NH2 1 
ATOM   1008 N N   . PRO A 1 130 ? 17.53123 8.93445   4.93330   1.000 45.80830 ? 132 PRO A N   1 
ATOM   1009 C CA  . PRO A 1 130 ? 18.99298 9.12634   4.94186   1.000 44.75003 ? 132 PRO A CA  1 
ATOM   1010 C C   . PRO A 1 130 ? 19.60224 9.11978   6.33308   1.000 42.42319 ? 132 PRO A C   1 
ATOM   1011 O O   . PRO A 1 130 ? 20.81437 8.89975   6.45996   1.000 42.86542 ? 132 PRO A O   1 
ATOM   1012 C CB  . PRO A 1 130 ? 19.17300 10.49023  4.25786   1.000 42.19329 ? 132 PRO A CB  1 
ATOM   1013 C CG  . PRO A 1 130 ? 17.97137 10.60815  3.36956   1.000 44.58668 ? 132 PRO A CG  1 
ATOM   1014 C CD  . PRO A 1 130 ? 16.84830 9.96894   4.13288   1.000 41.05764 ? 132 PRO A CD  1 
ATOM   1015 N N   . ASN A 1 131 ? 18.80976 9.36296   7.37664   1.000 40.62332 ? 133 ASN A N   1 
ATOM   1016 C CA  . ASN A 1 131 ? 19.27136 9.24032   8.75140   1.000 45.01501 ? 133 ASN A CA  1 
ATOM   1017 C C   . ASN A 1 131 ? 18.95915 7.86681   9.35538   1.000 46.01634 ? 133 ASN A C   1 
ATOM   1018 O O   . ASN A 1 131 ? 18.94214 7.72022   10.58474  1.000 43.09275 ? 133 ASN A O   1 
ATOM   1019 C CB  . ASN A 1 131 ? 18.67688 10.36245  9.60711   1.000 45.25270 ? 133 ASN A CB  1 
ATOM   1020 C CG  . ASN A 1 131 ? 17.20565 10.15846  9.90460   1.000 43.08360 ? 133 ASN A CG  1 
ATOM   1021 O OD1 . ASN A 1 131 ? 16.52991 9.34153   9.26908   1.000 41.62323 ? 133 ASN A OD1 1 
ATOM   1022 N ND2 . ASN A 1 131 ? 16.69400 10.91840  10.86384  1.000 43.96078 ? 133 ASN A ND2 1 
ATOM   1023 N N   . PHE A 1 132 ? 18.68048 6.86768   8.51676   1.000 46.47248 ? 134 PHE A N   1 
ATOM   1024 C CA  . PHE A 1 132 ? 18.56913 5.46742   8.93138   1.000 44.98438 ? 134 PHE A CA  1 
ATOM   1025 C C   . PHE A 1 132 ? 17.38010 5.19522   9.84198   1.000 42.52285 ? 134 PHE A C   1 
ATOM   1026 O O   . PHE A 1 132 ? 17.34673 4.16834   10.52187  1.000 42.84185 ? 134 PHE A O   1 
ATOM   1027 C CB  . PHE A 1 132 ? 19.86698 4.99221   9.58915   1.000 41.50251 ? 134 PHE A CB  1 
ATOM   1028 C CG  . PHE A 1 132 ? 21.00239 4.87969   8.62103   1.000 44.45766 ? 134 PHE A CG  1 
ATOM   1029 C CD1 . PHE A 1 132 ? 20.94251 3.96482   7.57425   1.000 47.01939 ? 134 PHE A CD1 1 
ATOM   1030 C CD2 . PHE A 1 132 ? 22.09807 5.71914   8.71712   1.000 45.49804 ? 134 PHE A CD2 1 
ATOM   1031 C CE1 . PHE A 1 132 ? 21.97444 3.87756   6.65453   1.000 48.23086 ? 134 PHE A CE1 1 
ATOM   1032 C CE2 . PHE A 1 132 ? 23.13299 5.63420   7.81729   1.000 41.51371 ? 134 PHE A CE2 1 
ATOM   1033 C CZ  . PHE A 1 132 ? 23.07196 4.71373   6.77918   1.000 42.97264 ? 134 PHE A CZ  1 
ATOM   1034 N N   . THR A 1 133 ? 16.40789 6.09734   9.88351   1.000 40.39555 ? 135 THR A N   1 
ATOM   1035 C CA  . THR A 1 133 ? 15.10551 5.81909   10.47545  1.000 45.13021 ? 135 THR A CA  1 
ATOM   1036 C C   . THR A 1 133 ? 14.14247 5.40943   9.36474   1.000 42.21841 ? 135 THR A C   1 
ATOM   1037 O O   . THR A 1 133 ? 14.45526 5.52198   8.17850   1.000 41.15649 ? 135 THR A O   1 
ATOM   1038 C CB  . THR A 1 133 ? 14.57778 7.05757   11.21052  1.000 43.42660 ? 135 THR A CB  1 
ATOM   1039 O OG1 . THR A 1 133 ? 14.77242 8.20063   10.36951  1.000 41.39623 ? 135 THR A OG1 1 
ATOM   1040 C CG2 . THR A 1 133 ? 15.33721 7.27574   12.51355  1.000 42.47885 ? 135 THR A CG2 1 
ATOM   1041 N N   . ILE A 1 134 ? 12.95328 4.94079   9.74199   1.000 38.64354 ? 136 ILE A N   1 
ATOM   1042 C CA  . ILE A 1 134 ? 11.87743 4.77727   8.76705   1.000 40.78744 ? 136 ILE A CA  1 
ATOM   1043 C C   . ILE A 1 134 ? 10.59897 5.43354   9.30592   1.000 41.50884 ? 136 ILE A C   1 
ATOM   1044 O O   . ILE A 1 134 ? 10.27241 5.32142   10.49206  1.000 44.27223 ? 136 ILE A O   1 
ATOM   1045 C CB  . ILE A 1 134 ? 11.66241 3.28742   8.37950   1.000 45.06165 ? 136 ILE A CB  1 
ATOM   1046 C CG1 . ILE A 1 134 ? 10.80300 2.53493   9.38831   1.000 40.36372 ? 136 ILE A CG1 1 
ATOM   1047 C CG2 . ILE A 1 134 ? 13.01992 2.52554   8.15845   1.000 37.27785 ? 136 ILE A CG2 1 
ATOM   1048 C CD1 . ILE A 1 134 ? 10.51459 1.10610   8.93472   1.000 38.83041 ? 136 ILE A CD1 1 
ATOM   1049 N N   . LYS A 1 135 ? 9.89655  6.16389   8.44407   1.000 43.62186 ? 137 LYS A N   1 
ATOM   1050 C CA  . LYS A 1 135 ? 8.64259  6.81567   8.83592   1.000 45.24087 ? 137 LYS A CA  1 
ATOM   1051 C C   . LYS A 1 135 ? 7.54395  5.78687   8.66070   1.000 46.15632 ? 137 LYS A C   1 
ATOM   1052 O O   . LYS A 1 135 ? 6.89510  5.70867   7.62085   1.000 48.69491 ? 137 LYS A O   1 
ATOM   1053 C CB  . LYS A 1 135 ? 8.37115  8.06480   8.00451   1.000 45.46313 ? 137 LYS A CB  1 
ATOM   1054 C CG  . LYS A 1 135 ? 8.70354  9.36720   8.67748   1.000 50.46909 ? 137 LYS A CG  1 
ATOM   1055 C CD  . LYS A 1 135 ? 8.10593  9.42487   10.08077  1.000 59.46389 ? 137 LYS A CD  1 
ATOM   1056 C CE  . LYS A 1 135 ? 6.59313  9.65535   10.11314  1.000 63.65460 ? 137 LYS A CE  1 
ATOM   1057 N NZ  . LYS A 1 135 ? 6.18690  10.19216  11.45911  1.000 59.36684 ? 137 LYS A NZ  1 
ATOM   1058 N N   . GLY A 1 136 ? 7.33200  4.98478   9.69851   1.000 44.93366 ? 138 GLY A N   1 
ATOM   1059 C CA  . GLY A 1 136 ? 6.48496  3.82222   9.60612   1.000 43.46296 ? 138 GLY A CA  1 
ATOM   1060 C C   . GLY A 1 136 ? 5.07734  4.07693   10.10669  1.000 47.29524 ? 138 GLY A C   1 
ATOM   1061 O O   . GLY A 1 136 ? 4.69820  5.18386   10.48480  1.000 47.97109 ? 138 GLY A O   1 
ATOM   1062 N N   . SER A 1 137 ? 4.29161  3.00292   10.06787  1.000 47.36139 ? 139 SER A N   1 
ATOM   1063 C CA  . SER A 1 137 ? 3.00420  2.91135   10.74923  1.000 47.21043 ? 139 SER A CA  1 
ATOM   1064 C C   . SER A 1 137 ? 3.03867  1.57834   11.49306  1.000 49.71267 ? 139 SER A C   1 
ATOM   1065 O O   . SER A 1 137 ? 2.72744  0.51933   10.93127  1.000 47.06862 ? 139 SER A O   1 
ATOM   1066 C CB  . SER A 1 137 ? 1.83989  3.00485   9.77274   1.000 50.41912 ? 139 SER A CB  1 
ATOM   1067 O OG  . SER A 1 137 ? 0.60675  3.02823   10.45713  1.000 54.50578 ? 139 SER A OG  1 
ATOM   1068 N N   . PHE A 1 138 ? 3.44764  1.65136   12.75706  1.000 48.61602 ? 140 PHE A N   1 
ATOM   1069 C CA  . PHE A 1 138 ? 3.69502  0.51488   13.62840  1.000 38.58949 ? 140 PHE A CA  1 
ATOM   1070 C C   . PHE A 1 138 ? 3.13122  0.85683   14.99610  1.000 45.82051 ? 140 PHE A C   1 
ATOM   1071 O O   . PHE A 1 138 ? 3.39737  1.95452   15.49807  1.000 44.17667 ? 140 PHE A O   1 
ATOM   1072 C CB  . PHE A 1 138 ? 5.18728  0.27242   13.80095  1.000 43.56539 ? 140 PHE A CB  1 
ATOM   1073 C CG  . PHE A 1 138 ? 5.90178  -0.21949  12.58295  1.000 43.01977 ? 140 PHE A CG  1 
ATOM   1074 C CD1 . PHE A 1 138 ? 5.69977  -1.50482  12.10449  1.000 41.98366 ? 140 PHE A CD1 1 
ATOM   1075 C CD2 . PHE A 1 138 ? 6.86853  0.56657   11.98560  1.000 41.58888 ? 140 PHE A CD2 1 
ATOM   1076 C CE1 . PHE A 1 138 ? 6.41165  -1.96933  11.01963  1.000 40.05225 ? 140 PHE A CE1 1 
ATOM   1077 C CE2 . PHE A 1 138 ? 7.58040  0.10336   10.89346  1.000 40.11352 ? 140 PHE A CE2 1 
ATOM   1078 C CZ  . PHE A 1 138 ? 7.35315  -1.16357  10.41671  1.000 35.97156 ? 140 PHE A CZ  1 
ATOM   1079 N N   . LEU A 1 139 ? 2.40311  -0.08558  15.60950  1.000 43.85095 ? 141 LEU A N   1 
ATOM   1080 C CA  . LEU A 1 139 ? 1.88603  0.02955   16.96847  1.000 42.43078 ? 141 LEU A CA  1 
ATOM   1081 C C   . LEU A 1 139 ? 2.70673  -0.84730  17.92908  1.000 45.35860 ? 141 LEU A C   1 
ATOM   1082 O O   . LEU A 1 139 ? 3.67961  -1.49133  17.53755  1.000 45.98004 ? 141 LEU A O   1 
ATOM   1083 C CB  . LEU A 1 139 ? 0.40180  -0.35855  17.01624  1.000 42.88835 ? 141 LEU A CB  1 
ATOM   1084 C CG  . LEU A 1 139 ? -0.72000 0.46292   16.34802  1.000 50.13925 ? 141 LEU A CG  1 
ATOM   1085 C CD1 . LEU A 1 139 ? -0.48947 1.98075   16.41609  1.000 43.23922 ? 141 LEU A CD1 1 
ATOM   1086 C CD2 . LEU A 1 139 ? -0.94007 0.01888   14.91669  1.000 50.00122 ? 141 LEU A CD2 1 
ATOM   1087 N N   . ASN A 1 140 ? 2.31552  -0.86128  19.20881  1.000 46.88595 ? 142 ASN A N   1 
ATOM   1088 C CA  . ASN A 1 140 ? 2.93952  -1.76784  20.16845  1.000 43.88856 ? 142 ASN A CA  1 
ATOM   1089 C C   . ASN A 1 140 ? 2.76104  -3.19013  19.67167  1.000 46.82767 ? 142 ASN A C   1 
ATOM   1090 O O   . ASN A 1 140 ? 1.71360  -3.54893  19.12471  1.000 48.81191 ? 142 ASN A O   1 
ATOM   1091 C CB  . ASN A 1 140 ? 2.33155  -1.61109  21.58062  1.000 44.01267 ? 142 ASN A CB  1 
ATOM   1092 C CG  . ASN A 1 140 ? 2.96825  -2.56936  22.64469  1.000 58.40640 ? 142 ASN A CG  1 
ATOM   1093 O OD1 . ASN A 1 140 ? 2.76436  -3.79146  22.62683  1.000 61.20496 ? 142 ASN A OD1 1 
ATOM   1094 N ND2 . ASN A 1 140 ? 3.71013  -1.99001  23.59542  1.000 60.25153 ? 142 ASN A ND2 1 
ATOM   1095 N N   . GLY A 1 141 ? 3.79614  -4.00106  19.84209  1.000 45.50057 ? 143 GLY A N   1 
ATOM   1096 C CA  . GLY A 1 141 ? 3.74659  -5.35784  19.36206  1.000 43.97500 ? 143 GLY A CA  1 
ATOM   1097 C C   . GLY A 1 141 ? 4.03485  -5.52597  17.88961  1.000 41.44300 ? 143 GLY A C   1 
ATOM   1098 O O   . GLY A 1 141 ? 4.09265  -6.66642  17.42313  1.000 39.62265 ? 143 GLY A O   1 
ATOM   1099 N N   . SER A 1 142 ? 4.23154  -4.43363  17.13794  1.000 41.77530 ? 144 SER A N   1 
ATOM   1100 C CA  . SER A 1 142 ? 4.62827  -4.56332  15.74019  1.000 38.81272 ? 144 SER A CA  1 
ATOM   1101 C C   . SER A 1 142 ? 6.06487  -5.04984  15.58739  1.000 40.50071 ? 144 SER A C   1 
ATOM   1102 O O   . SER A 1 142 ? 6.48017  -5.36110  14.46206  1.000 39.16884 ? 144 SER A O   1 
ATOM   1103 C CB  . SER A 1 142 ? 4.44080  -3.23517  15.00905  1.000 40.76784 ? 144 SER A CB  1 
ATOM   1104 O OG  . SER A 1 142 ? 5.23880  -2.21630  15.58607  1.000 42.38610 ? 144 SER A OG  1 
ATOM   1105 N N   . CYS A 1 143 ? 6.81261  -5.13775  16.68982  1.000 39.75556 ? 145 CYS A N   1 
ATOM   1106 C CA  . CYS A 1 143 ? 8.18267  -5.64245  16.67590  1.000 34.65511 ? 145 CYS A CA  1 
ATOM   1107 C C   . CYS A 1 143 ? 8.28846  -7.01835  16.02179  1.000 38.53544 ? 145 CYS A C   1 
ATOM   1108 O O   . CYS A 1 143 ? 7.48664  -7.91942  16.27272  1.000 39.08998 ? 145 CYS A O   1 
ATOM   1109 C CB  . CYS A 1 143 ? 8.71673  -5.70827  18.10476  1.000 40.77232 ? 145 CYS A CB  1 
ATOM   1110 S SG  . CYS A 1 143 ? 8.42137  -4.18117  19.01359  1.000 44.51590 ? 145 CYS A SG  1 
ATOM   1111 N N   . GLY A 1 144 ? 9.31516  -7.18187  15.19102  1.000 39.35638 ? 146 GLY A N   1 
ATOM   1112 C CA  . GLY A 1 144 ? 9.53623  -8.40444  14.47302  1.000 35.93896 ? 146 GLY A CA  1 
ATOM   1113 C C   . GLY A 1 144 ? 8.98144  -8.40633  13.07022  1.000 35.96140 ? 146 GLY A C   1 
ATOM   1114 O O   . GLY A 1 144 ? 9.31812  -9.31273  12.30418  1.000 34.90402 ? 146 GLY A O   1 
ATOM   1115 N N   . SER A 1 145 ? 8.12733  -7.43746  12.72080  1.000 37.01439 ? 147 SER A N   1 
ATOM   1116 C CA  . SER A 1 145 ? 7.63189  -7.31907  11.35334  1.000 35.83974 ? 147 SER A CA  1 
ATOM   1117 C C   . SER A 1 145 ? 8.78488  -6.98996  10.41613  1.000 34.62056 ? 147 SER A C   1 
ATOM   1118 O O   . SER A 1 145 ? 9.81093  -6.44066  10.82989  1.000 35.80469 ? 147 SER A O   1 
ATOM   1119 C CB  . SER A 1 145 ? 6.56389  -6.23600  11.25743  1.000 35.87190 ? 147 SER A CB  1 
ATOM   1120 O OG  . SER A 1 145 ? 5.43745  -6.59994  12.02571  1.000 44.62877 ? 147 SER A OG  1 
ATOM   1121 N N   . VAL A 1 146 ? 8.60929  -7.30388  9.13141   1.000 32.29868 ? 148 VAL A N   1 
ATOM   1122 C CA  . VAL A 1 146 ? 9.73928  -7.23639  8.21652   1.000 35.25780 ? 148 VAL A CA  1 
ATOM   1123 C C   . VAL A 1 146 ? 9.43036  -6.36326  7.00259   1.000 33.46060 ? 148 VAL A C   1 
ATOM   1124 O O   . VAL A 1 146 ? 8.27559  -6.15467  6.61550   1.000 29.48223 ? 148 VAL A O   1 
ATOM   1125 C CB  . VAL A 1 146 ? 10.21623 -8.64814  7.77466   1.000 34.13889 ? 148 VAL A CB  1 
ATOM   1126 C CG1 . VAL A 1 146 ? 10.68055 -9.44644  8.97919   1.000 31.92064 ? 148 VAL A CG1 1 
ATOM   1127 C CG2 . VAL A 1 146 ? 9.12751  -9.38505  7.00992   1.000 29.11033 ? 148 VAL A CG2 1 
ATOM   1128 N N   . GLY A 1 147 ? 10.49778 -5.80050  6.44710   1.000 31.42848 ? 149 GLY A N   1 
ATOM   1129 C CA  . GLY A 1 147 ? 10.46235 -5.10963  5.18045   1.000 33.10240 ? 149 GLY A CA  1 
ATOM   1130 C C   . GLY A 1 147 ? 11.13995 -5.97019  4.13011   1.000 36.30429 ? 149 GLY A C   1 
ATOM   1131 O O   . GLY A 1 147 ? 12.06935 -6.72942  4.43049   1.000 29.33377 ? 149 GLY A O   1 
ATOM   1132 N N   . PHE A 1 148 ? 10.68057 -5.84704  2.88963   1.000 33.82720 ? 150 PHE A N   1 
ATOM   1133 C CA  . PHE A 1 148 ? 11.14766 -6.77305  1.87242   1.000 37.90961 ? 150 PHE A CA  1 
ATOM   1134 C C   . PHE A 1 148 ? 10.96585 -6.16719  0.49020   1.000 39.70690 ? 150 PHE A C   1 
ATOM   1135 O O   . PHE A 1 148 ? 10.17857 -5.23837  0.28553   1.000 40.06908 ? 150 PHE A O   1 
ATOM   1136 C CB  . PHE A 1 148 ? 10.41894 -8.12513  1.97114   1.000 33.70616 ? 150 PHE A CB  1 
ATOM   1137 C CG  . PHE A 1 148 ? 8.93578  -8.03241  1.80510   1.000 35.23592 ? 150 PHE A CG  1 
ATOM   1138 C CD1 . PHE A 1 148 ? 8.11942  -7.67696  2.87787   1.000 36.33139 ? 150 PHE A CD1 1 
ATOM   1139 C CD2 . PHE A 1 148 ? 8.34323  -8.30041  0.57537   1.000 35.02726 ? 150 PHE A CD2 1 
ATOM   1140 C CE1 . PHE A 1 148 ? 6.72227  -7.58911  2.72195   1.000 36.76919 ? 150 PHE A CE1 1 
ATOM   1141 C CE2 . PHE A 1 148 ? 6.95066  -8.21758  0.40906   1.000 35.28900 ? 150 PHE A CE2 1 
ATOM   1142 C CZ  . PHE A 1 148 ? 6.13559  -7.85918  1.49134   1.000 34.68616 ? 150 PHE A CZ  1 
ATOM   1143 N N   . ASN A 1 149 ? 11.72246 -6.71059  -0.45494  1.000 41.52135 ? 151 ASN A N   1 
ATOM   1144 C CA  . ASN A 1 149 ? 11.48775 -6.51528  -1.87210  1.000 38.19976 ? 151 ASN A CA  1 
ATOM   1145 C C   . ASN A 1 149 ? 11.29433 -7.88340  -2.51296  1.000 40.72109 ? 151 ASN A C   1 
ATOM   1146 O O   . ASN A 1 149 ? 11.76294 -8.89538  -1.99062  1.000 45.22876 ? 151 ASN A O   1 
ATOM   1147 C CB  . ASN A 1 149 ? 12.64602 -5.74002  -2.50447  1.000 36.88015 ? 151 ASN A CB  1 
ATOM   1148 C CG  . ASN A 1 149 ? 12.66749 -4.27598  -2.06084  1.000 42.18305 ? 151 ASN A CG  1 
ATOM   1149 O OD1 . ASN A 1 149 ? 11.81903 -3.49694  -2.47550  1.000 46.27591 ? 151 ASN A OD1 1 
ATOM   1150 N ND2 . ASN A 1 149 ? 13.61678 -3.90698  -1.20248  1.000 38.91944 ? 151 ASN A ND2 1 
ATOM   1151 N N   . ILE A 1 150 ? 10.54709 -7.93279  -3.60887  1.000 39.25922 ? 152 ILE A N   1 
ATOM   1152 C CA  . ILE A 1 150 ? 10.37692 -9.16451  -4.36673  1.000 40.34215 ? 152 ILE A CA  1 
ATOM   1153 C C   . ILE A 1 150 ? 10.84371 -8.90691  -5.78227  1.000 45.80207 ? 152 ILE A C   1 
ATOM   1154 O O   . ILE A 1 150 ? 10.26141 -8.07454  -6.48772  1.000 48.62158 ? 152 ILE A O   1 
ATOM   1155 C CB  . ILE A 1 150 ? 8.92983  -9.66355  -4.36196  1.000 40.82091 ? 152 ILE A CB  1 
ATOM   1156 C CG1 . ILE A 1 150 ? 8.38918  -9.64994  -2.93891  1.000 39.90616 ? 152 ILE A CG1 1 
ATOM   1157 C CG2 . ILE A 1 150 ? 8.88195  -11.08221 -4.92031  1.000 46.14187 ? 152 ILE A CG2 1 
ATOM   1158 C CD1 . ILE A 1 150 ? 7.11802  -10.41390 -2.77445  1.000 36.53580 ? 152 ILE A CD1 1 
ATOM   1159 N N   . ASP A 1 151 ? 11.91893 -9.58527  -6.17567  1.000 50.56906 ? 153 ASP A N   1 
ATOM   1160 C CA  . ASP A 1 151 ? 12.37542 -9.67864  -7.55884  1.000 51.19089 ? 153 ASP A CA  1 
ATOM   1161 C C   . ASP A 1 151 ? 12.02976 -11.08264 -8.03221  1.000 59.38104 ? 153 ASP A C   1 
ATOM   1162 O O   . ASP A 1 151 ? 12.76397 -12.02908 -7.73668  1.000 62.40380 ? 153 ASP A O   1 
ATOM   1163 C CB  . ASP A 1 151 ? 13.87242 -9.42992  -7.67183  1.000 59.15470 ? 153 ASP A CB  1 
ATOM   1164 C CG  . ASP A 1 151 ? 14.38911 -9.62217  -9.09249  1.000 67.39106 ? 153 ASP A CG  1 
ATOM   1165 O OD1 . ASP A 1 151 ? 13.55471 -9.79389  -10.02449 1.000 64.41674 ? 153 ASP A OD1 1 
ATOM   1166 O OD2 . ASP A 1 151 ? 15.63421 -9.59716  -9.26827  1.000 64.85649 ? 153 ASP A OD2 1 
ATOM   1167 N N   . TYR A 1 152 ? 10.93414 -11.18919 -8.79064  1.000 59.58056 ? 154 TYR A N   1 
ATOM   1168 C CA  . TYR A 1 152 ? 10.28804 -12.42432 -9.22983  1.000 63.83767 ? 154 TYR A CA  1 
ATOM   1169 C C   . TYR A 1 152 ? 10.75840 -13.64586 -8.46113  1.000 67.36485 ? 154 TYR A C   1 
ATOM   1170 O O   . TYR A 1 152 ? 11.85777 -14.15858 -8.70678  1.000 67.32000 ? 154 TYR A O   1 
ATOM   1171 C CB  . TYR A 1 152 ? 10.50245 -12.66877 -10.72780 1.000 66.92547 ? 154 TYR A CB  1 
ATOM   1172 C CG  . TYR A 1 152 ? 9.87416  -13.96677 -11.24316 1.000 71.48410 ? 154 TYR A CG  1 
ATOM   1173 C CD1 . TYR A 1 152 ? 8.52740  -14.02383 -11.62166 1.000 72.98111 ? 154 TYR A CD1 1 
ATOM   1174 C CD2 . TYR A 1 152 ? 10.63536 -15.13161 -11.36443 1.000 71.18574 ? 154 TYR A CD2 1 
ATOM   1175 C CE1 . TYR A 1 152 ? 7.96223  -15.21529 -12.09518 1.000 75.26438 ? 154 TYR A CE1 1 
ATOM   1176 C CE2 . TYR A 1 152 ? 10.07612 -16.32075 -11.82848 1.000 70.60661 ? 154 TYR A CE2 1 
ATOM   1177 C CZ  . TYR A 1 152 ? 8.74534  -16.35326 -12.19257 1.000 69.25044 ? 154 TYR A CZ  1 
ATOM   1178 O OH  . TYR A 1 152 ? 8.19903  -17.52154 -12.65426 1.000 70.00320 ? 154 TYR A OH  1 
ATOM   1179 N N   . ASP A 1 153 ? 9.92012  -14.09676 -7.53050  1.000 66.78921 ? 155 ASP A N   1 
ATOM   1180 C CA  . ASP A 1 153 ? 10.05599 -15.35499 -6.80460  1.000 60.66800 ? 155 ASP A CA  1 
ATOM   1181 C C   . ASP A 1 153 ? 11.17505 -15.30463 -5.76009  1.000 54.66115 ? 155 ASP A C   1 
ATOM   1182 O O   . ASP A 1 153 ? 11.28681 -16.22772 -4.95014  1.000 58.71271 ? 155 ASP A O   1 
ATOM   1183 C CB  . ASP A 1 153 ? 10.18340 -16.52429 -7.81209  1.000 59.51323 ? 155 ASP A CB  1 
ATOM   1184 C CG  . ASP A 1 153 ? 11.62651 -16.86421 -8.24307  1.000 63.55934 ? 155 ASP A CG  1 
ATOM   1185 O OD1 . ASP A 1 153 ? 12.52011 -16.01523 -8.41953  1.000 65.81878 ? 155 ASP A OD1 1 
ATOM   1186 O OD2 . ASP A 1 153 ? 11.87320 -18.06886 -8.44256  1.000 64.52736 ? 155 ASP A OD2 1 
ATOM   1187 N N   . CYS A 1 154 ? 11.97171 -14.22330 -5.70316  1.000 51.15917 ? 156 CYS A N   1 
ATOM   1188 C CA  . CYS A 1 154 ? 13.00067 -14.08225 -4.66309  1.000 55.30113 ? 156 CYS A CA  1 
ATOM   1189 C C   . CYS A 1 154 ? 12.66815 -12.92283 -3.71674  1.000 51.59367 ? 156 CYS A C   1 
ATOM   1190 O O   . CYS A 1 154 ? 12.74849 -11.74577 -4.09239  1.000 43.58132 ? 156 CYS A O   1 
ATOM   1191 C CB  . CYS A 1 154 ? 14.40097 -13.89650 -5.25125  1.000 52.46920 ? 156 CYS A CB  1 
ATOM   1192 S SG  . CYS A 1 154 ? 15.74360 -14.06311 -4.00078  1.000 60.16174 ? 156 CYS A SG  1 
ATOM   1193 N N   . VAL A 1 155 ? 12.33976 -13.26180 -2.47791  1.000 47.20860 ? 157 VAL A N   1 
ATOM   1194 C CA  . VAL A 1 155 ? 12.13731 -12.27404 -1.43270  1.000 45.14618 ? 157 VAL A CA  1 
ATOM   1195 C C   . VAL A 1 155 ? 13.49061 -11.86897 -0.85453  1.000 45.89874 ? 157 VAL A C   1 
ATOM   1196 O O   . VAL A 1 155 ? 14.21457 -12.70613 -0.31044  1.000 43.11580 ? 157 VAL A O   1 
ATOM   1197 C CB  . VAL A 1 155 ? 11.21282 -12.82483 -0.34495  1.000 41.18744 ? 157 VAL A CB  1 
ATOM   1198 C CG1 . VAL A 1 155 ? 10.95035 -11.73456 0.74493   1.000 38.56093 ? 157 VAL A CG1 1 
ATOM   1199 C CG2 . VAL A 1 155 ? 9.92664  -13.31526 -0.99193  1.000 37.54720 ? 157 VAL A CG2 1 
ATOM   1200 N N   . SER A 1 156 ? 13.83537 -10.58195 -0.97310  1.000 41.73617 ? 158 SER A N   1 
ATOM   1201 C CA  . SER A 1 156 ? 14.98669 -10.01113 -0.28887  1.000 38.69410 ? 158 SER A CA  1 
ATOM   1202 C C   . SER A 1 156 ? 14.48037 -9.38766  1.00112   1.000 42.19485 ? 158 SER A C   1 
ATOM   1203 O O   . SER A 1 156 ? 13.72337 -8.41219  0.98231   1.000 43.23260 ? 158 SER A O   1 
ATOM   1204 C CB  . SER A 1 156 ? 15.70711 -8.97818  -1.14433  1.000 38.19298 ? 158 SER A CB  1 
ATOM   1205 O OG  . SER A 1 156 ? 16.00788 -9.50825  -2.41873  1.000 49.65279 ? 158 SER A OG  1 
ATOM   1206 N N   . PHE A 1 157 ? 14.87002 -9.97286  2.11399   1.000 38.11933 ? 159 PHE A N   1 
ATOM   1207 C CA  . PHE A 1 157 ? 14.55001 -9.42395  3.41236   1.000 34.57313 ? 159 PHE A CA  1 
ATOM   1208 C C   . PHE A 1 157 ? 15.58369 -8.36214  3.74848   1.000 34.55211 ? 159 PHE A C   1 
ATOM   1209 O O   . PHE A 1 157 ? 16.78566 -8.63492  3.71388   1.000 37.28317 ? 159 PHE A O   1 
ATOM   1210 C CB  . PHE A 1 157 ? 14.53422 -10.54761 4.44580   1.000 35.91780 ? 159 PHE A CB  1 
ATOM   1211 C CG  . PHE A 1 157 ? 13.35961 -11.44474 4.31448   1.000 31.80021 ? 159 PHE A CG  1 
ATOM   1212 C CD1 . PHE A 1 157 ? 12.09813 -10.99133 4.62675   1.000 31.15736 ? 159 PHE A CD1 1 
ATOM   1213 C CD2 . PHE A 1 157 ? 13.50656 -12.72456 3.85140   1.000 38.56441 ? 159 PHE A CD2 1 
ATOM   1214 C CE1 . PHE A 1 157 ? 10.99976 -11.80796 4.49921   1.000 30.39559 ? 159 PHE A CE1 1 
ATOM   1215 C CE2 . PHE A 1 157 ? 12.40571 -13.55974 3.71603   1.000 39.75398 ? 159 PHE A CE2 1 
ATOM   1216 C CZ  . PHE A 1 157 ? 11.15380 -13.09819 4.03907   1.000 38.03643 ? 159 PHE A CZ  1 
ATOM   1217 N N   . CYS A 1 158 ? 15.13116 -7.15054  4.07267   1.000 34.48386 ? 160 CYS A N   1 
ATOM   1218 C CA  . CYS A 1 158 ? 16.07663 -6.08613  4.34602   1.000 37.36265 ? 160 CYS A CA  1 
ATOM   1219 C C   . CYS A 1 158 ? 15.87781 -5.34937  5.66056   1.000 32.72308 ? 160 CYS A C   1 
ATOM   1220 O O   . CYS A 1 158 ? 16.79909 -4.64467  6.07380   1.000 39.21451 ? 160 CYS A O   1 
ATOM   1221 C CB  . CYS A 1 158 ? 16.06599 -5.05472  3.21063   1.000 38.82076 ? 160 CYS A CB  1 
ATOM   1222 S SG  . CYS A 1 158 ? 14.51788 -4.18618  2.98449   1.000 40.40312 ? 160 CYS A SG  1 
ATOM   1223 N N   . TYR A 1 159 ? 14.73491 -5.48753  6.33394   1.000 33.72733 ? 161 TYR A N   1 
ATOM   1224 C CA  . TYR A 1 159 ? 14.46846 -4.71662  7.54878   1.000 34.14806 ? 161 TYR A CA  1 
ATOM   1225 C C   . TYR A 1 159 ? 13.68092 -5.54782  8.54188   1.000 29.85858 ? 161 TYR A C   1 
ATOM   1226 O O   . TYR A 1 159 ? 12.73872 -6.23929  8.16489   1.000 32.17514 ? 161 TYR A O   1 
ATOM   1227 C CB  . TYR A 1 159 ? 13.66943 -3.44833  7.24589   1.000 31.63189 ? 161 TYR A CB  1 
ATOM   1228 C CG  . TYR A 1 159 ? 13.28791 -2.62607  8.45864   1.000 33.27393 ? 161 TYR A CG  1 
ATOM   1229 C CD1 . TYR A 1 159 ? 14.22176 -1.81337  9.09041   1.000 34.84843 ? 161 TYR A CD1 1 
ATOM   1230 C CD2 . TYR A 1 159 ? 11.98507 -2.62631  8.94913   1.000 33.04906 ? 161 TYR A CD2 1 
ATOM   1231 C CE1 . TYR A 1 159 ? 13.87863 -1.04120  10.18382  1.000 32.18071 ? 161 TYR A CE1 1 
ATOM   1232 C CE2 . TYR A 1 159 ? 11.63426 -1.86815  10.04203  1.000 30.08983 ? 161 TYR A CE2 1 
ATOM   1233 C CZ  . TYR A 1 159 ? 12.59611 -1.08001  10.66044  1.000 33.09883 ? 161 TYR A CZ  1 
ATOM   1234 O OH  . TYR A 1 159 ? 12.28683 -0.30929  11.74581  1.000 29.71224 ? 161 TYR A OH  1 
ATOM   1235 N N   . MET A 1 160 ? 14.04409 -5.47137  9.81106   1.000 31.66317 ? 162 MET A N   1 
ATOM   1236 C CA  . MET A 1 160 ? 13.20178 -6.04394  10.85247  1.000 35.40456 ? 162 MET A CA  1 
ATOM   1237 C C   . MET A 1 160 ? 12.91676 -4.97882  11.90014  1.000 31.68972 ? 162 MET A C   1 
ATOM   1238 O O   . MET A 1 160 ? 13.85059 -4.36239  12.41315  1.000 34.66599 ? 162 MET A O   1 
ATOM   1239 C CB  . MET A 1 160 ? 13.84959 -7.25569  11.50362  1.000 28.47182 ? 162 MET A CB  1 
ATOM   1240 C CG  . MET A 1 160 ? 13.06064 -7.69525  12.70882  1.000 31.42144 ? 162 MET A CG  1 
ATOM   1241 S SD  . MET A 1 160 ? 13.62805 -9.23298  13.43762  1.000 40.34119 ? 162 MET A SD  1 
ATOM   1242 C CE  . MET A 1 160 ? 12.54221 -10.39402 12.59869  1.000 41.44561 ? 162 MET A CE  1 
ATOM   1243 N N   . HIS A 1 161 ? 11.64346 -4.77152  12.23113  1.000 30.39111 ? 163 HIS A N   1 
ATOM   1244 C CA  . HIS A 1 161 ? 11.28692 -3.66320  13.11163  1.000 34.05240 ? 163 HIS A CA  1 
ATOM   1245 C C   . HIS A 1 161 ? 11.60898 -3.96800  14.56174  1.000 33.25653 ? 163 HIS A C   1 
ATOM   1246 O O   . HIS A 1 161 ? 11.28593 -5.04346  15.06693  1.000 38.49600 ? 163 HIS A O   1 
ATOM   1247 C CB  . HIS A 1 161 ? 9.80794  -3.32528  13.01521  1.000 33.97236 ? 163 HIS A CB  1 
ATOM   1248 C CG  . HIS A 1 161 ? 9.42124  -2.16024  13.86539  1.000 38.39685 ? 163 HIS A CG  1 
ATOM   1249 N ND1 . HIS A 1 161 ? 9.99674  -0.91770  13.71225  1.000 35.67077 ? 163 HIS A ND1 1 
ATOM   1250 C CD2 . HIS A 1 161 ? 8.56163  -2.05417  14.90931  1.000 36.44671 ? 163 HIS A CD2 1 
ATOM   1251 C CE1 . HIS A 1 161 ? 9.49453  -0.08781  14.60825  1.000 35.88300 ? 163 HIS A CE1 1 
ATOM   1252 N NE2 . HIS A 1 161 ? 8.62234  -0.75276  15.34629  1.000 40.28775 ? 163 HIS A NE2 1 
ATOM   1253 N N   . HIS A 1 162 ? 12.17516 -2.97555  15.24748  1.000 34.50966 ? 164 HIS A N   1 
ATOM   1254 C CA  . HIS A 1 162 ? 12.56268 -3.08531  16.65229  1.000 39.93932 ? 164 HIS A CA  1 
ATOM   1255 C C   . HIS A 1 162 ? 11.84398 -2.09163  17.55886  1.000 38.61005 ? 164 HIS A C   1 
ATOM   1256 O O   . HIS A 1 162 ? 11.11749 -2.51621  18.46489  1.000 38.97539 ? 164 HIS A O   1 
ATOM   1257 C CB  . HIS A 1 162 ? 14.07759 -2.91177  16.76807  1.000 36.39500 ? 164 HIS A CB  1 
ATOM   1258 C CG  . HIS A 1 162 ? 14.83806 -4.16102  16.45008  1.000 36.29210 ? 164 HIS A CG  1 
ATOM   1259 N ND1 . HIS A 1 162 ? 15.43430 -4.93136  17.42259  1.000 34.04586 ? 164 HIS A ND1 1 
ATOM   1260 C CD2 . HIS A 1 162 ? 15.07803 -4.78618  15.27035  1.000 33.23052 ? 164 HIS A CD2 1 
ATOM   1261 C CE1 . HIS A 1 162 ? 16.02831 -5.96956  16.85409  1.000 38.05470 ? 164 HIS A CE1 1 
ATOM   1262 N NE2 . HIS A 1 162 ? 15.82779 -5.90551  15.55003  1.000 34.29015 ? 164 HIS A NE2 1 
ATOM   1263 N N   . MET A 1 163 ? 12.03874 -0.78585  17.37161  1.000 40.25498 ? 165 MET A N   1 
ATOM   1264 C CA  . MET A 1 163 ? 11.53473 0.19210   18.32792  1.000 41.78455 ? 165 MET A CA  1 
ATOM   1265 C C   . MET A 1 163 ? 10.99298 1.43124   17.63240  1.000 44.29178 ? 165 MET A C   1 
ATOM   1266 O O   . MET A 1 163 ? 11.36941 1.77111   16.50710  1.000 37.91943 ? 165 MET A O   1 
ATOM   1267 C CB  . MET A 1 163 ? 12.61083 0.71216   19.28386  1.000 44.64874 ? 165 MET A CB  1 
ATOM   1268 C CG  . MET A 1 163 ? 13.70458 -0.24257  19.57312  1.000 46.53869 ? 165 MET A CG  1 
ATOM   1269 S SD  . MET A 1 163 ? 15.09949 0.67231   20.18707  1.000 60.18906 ? 165 MET A SD  1 
ATOM   1270 C CE  . MET A 1 163 ? 14.28453 1.71752   21.41751  1.000 51.09738 ? 165 MET A CE  1 
ATOM   1271 N N   . GLU A 1 164 ? 10.13673 2.13422   18.36455  1.000 45.89603 ? 166 GLU A N   1 
ATOM   1272 C CA  . GLU A 1 164 ? 9.79008  3.50743   18.06181  1.000 46.88775 ? 166 GLU A CA  1 
ATOM   1273 C C   . GLU A 1 164 ? 10.79717 4.44057   18.72836  1.000 48.15983 ? 166 GLU A C   1 
ATOM   1274 O O   . GLU A 1 164 ? 11.18449 4.24179   19.88234  1.000 50.22312 ? 166 GLU A O   1 
ATOM   1275 C CB  . GLU A 1 164 ? 8.36869  3.81336   18.54357  1.000 47.33810 ? 166 GLU A CB  1 
ATOM   1276 C CG  . GLU A 1 164 ? 7.74262  5.07420   17.94857  1.000 50.17740 ? 166 GLU A CG  1 
ATOM   1277 C CD  . GLU A 1 164 ? 6.23293  5.11272   18.16534  1.000 54.51397 ? 166 GLU A CD  1 
ATOM   1278 O OE1 . GLU A 1 164 ? 5.78897  5.55696   19.25660  1.000 52.49723 ? 166 GLU A OE1 1 
ATOM   1279 O OE2 . GLU A 1 164 ? 5.49286  4.66932   17.25102  1.000 51.97096 ? 166 GLU A OE2 1 
ATOM   1280 N N   . LEU A 1 165 ? 11.25549 5.41645   17.98125  1.000 49.11462 ? 167 LEU A N   1 
ATOM   1281 C CA  . LEU A 1 165 ? 11.95741 6.41674   18.76108  1.000 52.65843 ? 167 LEU A CA  1 
ATOM   1282 C C   . LEU A 1 165 ? 10.96386 7.47518   19.22650  1.000 62.39343 ? 167 LEU A C   1 
ATOM   1283 O O   . LEU A 1 165 ? 10.10109 7.89376   18.44738  1.000 60.46948 ? 167 LEU A O   1 
ATOM   1284 C CB  . LEU A 1 165 ? 13.04912 7.07885   17.93545  1.000 53.58712 ? 167 LEU A CB  1 
ATOM   1285 C CG  . LEU A 1 165 ? 14.03071 6.17156   17.20290  1.000 49.76888 ? 167 LEU A CG  1 
ATOM   1286 C CD1 . LEU A 1 165 ? 14.88774 7.03242   16.28788  1.000 50.92034 ? 167 LEU A CD1 1 
ATOM   1287 C CD2 . LEU A 1 165 ? 14.89745 5.38836   18.19381  1.000 46.06111 ? 167 LEU A CD2 1 
ATOM   1288 N N   . PRO A 1 166 ? 11.06293 7.92918   20.48851  1.000 62.10707 ? 168 PRO A N   1 
ATOM   1289 C CA  . PRO A 1 166 ? 10.09065 8.90597   21.01171  1.000 67.58044 ? 168 PRO A CA  1 
ATOM   1290 C C   . PRO A 1 166 ? 9.72944  10.05242  20.06558  1.000 69.19652 ? 168 PRO A C   1 
ATOM   1291 O O   . PRO A 1 166 ? 8.65079  10.64363  20.20675  1.000 70.01436 ? 168 PRO A O   1 
ATOM   1292 C CB  . PRO A 1 166 ? 10.78285 9.41983   22.28144  1.000 69.33377 ? 168 PRO A CB  1 
ATOM   1293 C CG  . PRO A 1 166 ? 11.54425 8.20222   22.77845  1.000 66.85669 ? 168 PRO A CG  1 
ATOM   1294 C CD  . PRO A 1 166 ? 11.96885 7.42705   21.54240  1.000 59.79787 ? 168 PRO A CD  1 
ATOM   1295 N N   . THR A 1 167 ? 10.59292 10.36544  19.08915  1.000 64.69909 ? 169 THR A N   1 
ATOM   1296 C CA  . THR A 1 167 ? 10.21556 11.31784  18.04846  1.000 58.78542 ? 169 THR A CA  1 
ATOM   1297 C C   . THR A 1 167 ? 9.14385  10.78002  17.09926  1.000 58.11710 ? 169 THR A C   1 
ATOM   1298 O O   . THR A 1 167 ? 8.76927  11.48512  16.15256  1.000 60.20731 ? 169 THR A O   1 
ATOM   1299 C CB  . THR A 1 167 ? 11.43842 11.72131  17.23336  1.000 63.86877 ? 169 THR A CB  1 
ATOM   1300 O OG1 . THR A 1 167 ? 11.61789 10.77869  16.17538  1.000 64.45477 ? 169 THR A OG1 1 
ATOM   1301 C CG2 . THR A 1 167 ? 12.67626 11.72718  18.09053  1.000 63.99209 ? 169 THR A CG2 1 
ATOM   1302 N N   . GLY A 1 168 ? 8.65455  9.55480   17.30509  1.000 61.53165 ? 170 GLY A N   1 
ATOM   1303 C CA  . GLY A 1 168 ? 7.59883  8.99277   16.49169  1.000 51.73205 ? 170 GLY A CA  1 
ATOM   1304 C C   . GLY A 1 168 ? 8.06467  8.20271   15.28640  1.000 49.13480 ? 170 GLY A C   1 
ATOM   1305 O O   . GLY A 1 168 ? 7.22465  7.64444   14.57632  1.000 50.32691 ? 170 GLY A O   1 
ATOM   1306 N N   . VAL A 1 169 ? 9.36907  8.15729   15.00962  1.000 51.00509 ? 171 VAL A N   1 
ATOM   1307 C CA  . VAL A 1 169 ? 9.87608  7.39095   13.87674  1.000 47.81021 ? 171 VAL A CA  1 
ATOM   1308 C C   . VAL A 1 169 ? 10.40261 6.05821   14.38695  1.000 46.08823 ? 171 VAL A C   1 
ATOM   1309 O O   . VAL A 1 169 ? 10.43086 5.80667   15.59675  1.000 43.52273 ? 171 VAL A O   1 
ATOM   1310 C CB  . VAL A 1 169 ? 10.97599 8.13979   13.11858  1.000 48.10304 ? 171 VAL A CB  1 
ATOM   1311 C CG1 . VAL A 1 169 ? 10.44552 9.46083   12.57227  1.000 53.62545 ? 171 VAL A CG1 1 
ATOM   1312 C CG2 . VAL A 1 169 ? 12.18469 8.31149   14.02483  1.000 52.22986 ? 171 VAL A CG2 1 
ATOM   1313 N N   . HIS A 1 170 ? 10.83809 5.20270   13.46866  1.000 43.82463 ? 172 HIS A N   1 
ATOM   1314 C CA  . HIS A 1 170 ? 11.06441 3.79986   13.77225  1.000 38.95834 ? 172 HIS A CA  1 
ATOM   1315 C C   . HIS A 1 170 ? 12.48660 3.39042   13.40785  1.000 36.63112 ? 172 HIS A C   1 
ATOM   1316 O O   . HIS A 1 170 ? 13.09657 3.92790   12.48175  1.000 38.95114 ? 172 HIS A O   1 
ATOM   1317 C CB  . HIS A 1 170 ? 10.01829 2.94548   13.05566  1.000 36.11181 ? 172 HIS A CB  1 
ATOM   1318 C CG  . HIS A 1 170 ? 8.61336  3.32916   13.40816  1.000 44.74477 ? 172 HIS A CG  1 
ATOM   1319 N ND1 . HIS A 1 170 ? 7.81996  4.10157   12.58294  1.000 43.29199 ? 172 HIS A ND1 1 
ATOM   1320 C CD2 . HIS A 1 170 ? 7.87653  3.09176   14.52275  1.000 42.82628 ? 172 HIS A CD2 1 
ATOM   1321 C CE1 . HIS A 1 170 ? 6.64873  4.30482   13.16378  1.000 42.25695 ? 172 HIS A CE1 1 
ATOM   1322 N NE2 . HIS A 1 170 ? 6.65568  3.70069   14.34061  1.000 44.26031 ? 172 HIS A NE2 1 
ATOM   1323 N N   . ALA A 1 171 ? 13.00927 2.43468   14.16278  1.000 31.92263 ? 173 ALA A N   1 
ATOM   1324 C CA  . ALA A 1 171 ? 14.38653 1.98713   14.05502  1.000 29.17928 ? 173 ALA A CA  1 
ATOM   1325 C C   . ALA A 1 171 ? 14.40030 0.46647   14.05121  1.000 29.27725 ? 173 ALA A C   1 
ATOM   1326 O O   . ALA A 1 171 ? 13.59390 -0.17523  14.73845  1.000 31.21946 ? 173 ALA A O   1 
ATOM   1327 C CB  . ALA A 1 171 ? 15.23102 2.53419   15.22898  1.000 28.53169 ? 173 ALA A CB  1 
ATOM   1328 N N   . GLY A 1 172 ? 15.30594 -0.11298  13.27801  1.000 27.25954 ? 174 GLY A N   1 
ATOM   1329 C CA  . GLY A 1 172 ? 15.38566 -1.54962  13.23595  1.000 29.87871 ? 174 GLY A CA  1 
ATOM   1330 C C   . GLY A 1 172 ? 16.69024 -1.98776  12.62712  1.000 34.19612 ? 174 GLY A C   1 
ATOM   1331 O O   . GLY A 1 172 ? 17.60716 -1.18374  12.44111  1.000 31.05410 ? 174 GLY A O   1 
ATOM   1332 N N   . THR A 1 173 ? 16.75340 -3.28519  12.31374  1.000 30.33273 ? 175 THR A N   1 
ATOM   1333 C CA  . THR A 1 173 ? 17.96169 -3.94324  11.84735  1.000 31.97232 ? 175 THR A CA  1 
ATOM   1334 C C   . THR A 1 173 ? 17.72516 -4.63334  10.51229  1.000 35.90666 ? 175 THR A C   1 
ATOM   1335 O O   . THR A 1 173 ? 16.58456 -4.86391  10.09582  1.000 36.92643 ? 175 THR A O   1 
ATOM   1336 C CB  . THR A 1 173 ? 18.45324 -4.99420  12.86763  1.000 35.28386 ? 175 THR A CB  1 
ATOM   1337 O OG1 . THR A 1 173 ? 17.60380 -6.14670  12.82517  1.000 29.86984 ? 175 THR A OG1 1 
ATOM   1338 C CG2 . THR A 1 173 ? 18.43907 -4.43044  14.27849  1.000 34.13093 ? 175 THR A CG2 1 
ATOM   1339 N N   . ASP A 1 174 ? 18.82834 -4.99397  9.85460   1.000 39.37326 ? 176 ASP A N   1 
ATOM   1340 C CA  . ASP A 1 174 ? 18.79207 -6.00123  8.79501   1.000 36.77443 ? 176 ASP A CA  1 
ATOM   1341 C C   . ASP A 1 174 ? 18.54906 -7.39215  9.41538   1.000 33.68985 ? 176 ASP A C   1 
ATOM   1342 O O   . ASP A 1 174 ? 18.43558 -7.55036  10.62841  1.000 34.12409 ? 176 ASP A O   1 
ATOM   1343 C CB  . ASP A 1 174 ? 20.08608 -5.94771  7.96875   1.000 36.08132 ? 176 ASP A CB  1 
ATOM   1344 C CG  . ASP A 1 174 ? 21.35546 -6.26433  8.79494   1.000 42.05360 ? 176 ASP A CG  1 
ATOM   1345 O OD1 . ASP A 1 174 ? 21.31937 -7.14049  9.70437   1.000 40.00452 ? 176 ASP A OD1 1 
ATOM   1346 O OD2 . ASP A 1 174 ? 22.41313 -5.64881  8.51262   1.000 45.67935 ? 176 ASP A OD2 1 
ATOM   1347 N N   . LEU A 1 175 ? 18.48296 -8.43120  8.59417   1.000 40.01717 ? 177 LEU A N   1 
ATOM   1348 C CA  . LEU A 1 175 ? 18.13311 -9.72815  9.17168   1.000 36.94177 ? 177 LEU A CA  1 
ATOM   1349 C C   . LEU A 1 175 ? 19.32241 -10.41359 9.83705   1.000 42.81840 ? 177 LEU A C   1 
ATOM   1350 O O   . LEU A 1 175 ? 19.14873 -11.48112 10.43916  1.000 37.39667 ? 177 LEU A O   1 
ATOM   1351 C CB  . LEU A 1 175 ? 17.50239 -10.63278 8.11195   1.000 32.72765 ? 177 LEU A CB  1 
ATOM   1352 C CG  . LEU A 1 175 ? 15.97188 -10.55265 8.07330   1.000 35.34976 ? 177 LEU A CG  1 
ATOM   1353 C CD1 . LEU A 1 175 ? 15.39345 -11.20388 9.29577   1.000 34.15115 ? 177 LEU A CD1 1 
ATOM   1354 C CD2 . LEU A 1 175 ? 15.45631 -9.09488  7.94525   1.000 37.04379 ? 177 LEU A CD2 1 
ATOM   1355 N N   . GLU A 1 176 ? 20.50946 -9.80997  9.76229   1.000 43.65756 ? 178 GLU A N   1 
ATOM   1356 C CA  . GLU A 1 176 ? 21.67538 -10.24592 10.51429  1.000 43.68968 ? 178 GLU A CA  1 
ATOM   1357 C C   . GLU A 1 176 ? 21.78681 -9.54639  11.86249  1.000 41.96862 ? 178 GLU A C   1 
ATOM   1358 O O   . GLU A 1 176 ? 22.77689 -9.75004  12.57198  1.000 41.71971 ? 178 GLU A O   1 
ATOM   1359 C CB  . GLU A 1 176 ? 22.95713 -10.01503 9.69268   1.000 43.46673 ? 178 GLU A CB  1 
ATOM   1360 C CG  . GLU A 1 176 ? 23.35977 -11.19725 8.78281   1.000 50.27542 ? 178 GLU A CG  1 
ATOM   1361 C CD  . GLU A 1 176 ? 23.87979 -10.75266 7.41528   1.000 65.81386 ? 178 GLU A CD  1 
ATOM   1362 O OE1 . GLU A 1 176 ? 24.02247 -9.52512  7.18315   1.000 74.38865 ? 178 GLU A OE1 1 
ATOM   1363 O OE2 . GLU A 1 176 ? 24.14282 -11.62988 6.56242   1.000 66.21937 ? 178 GLU A OE2 1 
ATOM   1364 N N   . GLY A 1 177 ? 20.81580 -8.71043  12.22228  1.000 40.54901 ? 179 GLY A N   1 
ATOM   1365 C CA  . GLY A 1 177 ? 20.74505 -8.13093  13.55337  1.000 37.50099 ? 179 GLY A CA  1 
ATOM   1366 C C   . GLY A 1 177 ? 21.48370 -6.82229  13.78340  1.000 37.88363 ? 179 GLY A C   1 
ATOM   1367 O O   . GLY A 1 177 ? 21.53253 -6.36091  14.92637  1.000 36.99994 ? 179 GLY A O   1 
ATOM   1368 N N   . ASN A 1 178 ? 22.07277 -6.22184  12.75659  1.000 38.01264 ? 180 ASN A N   1 
ATOM   1369 C CA  . ASN A 1 178 ? 22.77829 -4.95785  12.90173  1.000 35.38022 ? 180 ASN A CA  1 
ATOM   1370 C C   . ASN A 1 178 ? 21.81355 -3.82018  12.67069  1.000 38.31443 ? 180 ASN A C   1 
ATOM   1371 O O   . ASN A 1 178 ? 21.14342 -3.77768  11.63665  1.000 41.85618 ? 180 ASN A O   1 
ATOM   1372 C CB  . ASN A 1 178 ? 23.91785 -4.84765  11.89647  1.000 41.33909 ? 180 ASN A CB  1 
ATOM   1373 C CG  . ASN A 1 178 ? 24.86394 -5.99656  11.99365  1.000 44.22327 ? 180 ASN A CG  1 
ATOM   1374 O OD1 . ASN A 1 178 ? 24.85116 -6.90625  11.15396  1.000 42.98268 ? 180 ASN A OD1 1 
ATOM   1375 N ND2 . ASN A 1 178 ? 25.67217 -5.99361  13.04680  1.000 46.26586 ? 180 ASN A ND2 1 
ATOM   1376 N N   . PHE A 1 179 ? 21.75956 -2.89329  13.61333  1.000 38.42392 ? 181 PHE A N   1 
ATOM   1377 C CA  . PHE A 1 179 ? 20.85504 -1.76555  13.47157  1.000 35.51296 ? 181 PHE A CA  1 
ATOM   1378 C C   . PHE A 1 179 ? 21.22096 -0.92752  12.26575  1.000 36.72358 ? 181 PHE A C   1 
ATOM   1379 O O   . PHE A 1 179 ? 22.39340 -0.78091  11.92580  1.000 39.51311 ? 181 PHE A O   1 
ATOM   1380 C CB  . PHE A 1 179 ? 20.88415 -0.89796  14.72596  1.000 35.26737 ? 181 PHE A CB  1 
ATOM   1381 C CG  . PHE A 1 179 ? 19.77857 -1.20265  15.67076  1.000 39.17734 ? 181 PHE A CG  1 
ATOM   1382 C CD1 . PHE A 1 179 ? 18.52868 -0.61070  15.50948  1.000 36.96568 ? 181 PHE A CD1 1 
ATOM   1383 C CD2 . PHE A 1 179 ? 19.96585 -2.10228  16.70187  1.000 34.63854 ? 181 PHE A CD2 1 
ATOM   1384 C CE1 . PHE A 1 179 ? 17.50271 -0.89973  16.37696  1.000 36.64118 ? 181 PHE A CE1 1 
ATOM   1385 C CE2 . PHE A 1 179 ? 18.93706 -2.39168  17.57227  1.000 34.98079 ? 181 PHE A CE2 1 
ATOM   1386 C CZ  . PHE A 1 179 ? 17.70668 -1.79116  17.41212  1.000 35.20531 ? 181 PHE A CZ  1 
ATOM   1387 N N   . TYR A 1 180 ? 20.19876 -0.40179  11.59770  1.000 40.32022 ? 182 TYR A N   1 
ATOM   1388 C CA  . TYR A 1 180 ? 20.37315 0.73776   10.71155  1.000 37.45880 ? 182 TYR A CA  1 
ATOM   1389 C C   . TYR A 1 180 ? 20.52638 1.99144   11.56443  1.000 36.20365 ? 182 TYR A C   1 
ATOM   1390 O O   . TYR A 1 180 ? 19.60887 2.35300   12.30812  1.000 40.21267 ? 182 TYR A O   1 
ATOM   1391 C CB  . TYR A 1 180 ? 19.17545 0.87367   9.77811   1.000 38.12623 ? 182 TYR A CB  1 
ATOM   1392 C CG  . TYR A 1 180 ? 19.11721 -0.19292  8.72971   1.000 39.44412 ? 182 TYR A CG  1 
ATOM   1393 C CD1 . TYR A 1 180 ? 19.89459 -0.10639  7.56621   1.000 36.59733 ? 182 TYR A CD1 1 
ATOM   1394 C CD2 . TYR A 1 180 ? 18.30471 -1.29519  8.89985   1.000 38.09425 ? 182 TYR A CD2 1 
ATOM   1395 C CE1 . TYR A 1 180 ? 19.85000 -1.08026  6.61408   1.000 34.69416 ? 182 TYR A CE1 1 
ATOM   1396 C CE2 . TYR A 1 180 ? 18.24397 -2.28108  7.94757   1.000 36.68889 ? 182 TYR A CE2 1 
ATOM   1397 C CZ  . TYR A 1 180 ? 19.01796 -2.18056  6.80630   1.000 40.10985 ? 182 TYR A CZ  1 
ATOM   1398 O OH  . TYR A 1 180 ? 18.94208 -3.18955  5.86053   1.000 35.99471 ? 182 TYR A OH  1 
ATOM   1399 N N   . GLY A 1 181 ? 21.67962 2.64504   11.48073  1.000 40.30447 ? 183 GLY A N   1 
ATOM   1400 C CA  . GLY A 1 181 ? 21.89882 3.88569   12.19764  1.000 40.19433 ? 183 GLY A CA  1 
ATOM   1401 C C   . GLY A 1 181 ? 22.50677 3.67392   13.56756  1.000 43.42549 ? 183 GLY A C   1 
ATOM   1402 O O   . GLY A 1 181 ? 22.86690 2.55709   13.94292  1.000 40.68647 ? 183 GLY A O   1 
ATOM   1403 N N   . PRO A 1 182 ? 22.60458 4.74225   14.36249  1.000 45.49624 ? 184 PRO A N   1 
ATOM   1404 C CA  . PRO A 1 182 ? 23.29203 4.65927   15.65699  1.000 43.16431 ? 184 PRO A CA  1 
ATOM   1405 C C   . PRO A 1 182 ? 22.47155 4.05304   16.78386  1.000 41.44235 ? 184 PRO A C   1 
ATOM   1406 O O   . PRO A 1 182 ? 22.87533 4.17508   17.94041  1.000 44.30954 ? 184 PRO A O   1 
ATOM   1407 C CB  . PRO A 1 182 ? 23.60136 6.13281   15.96807  1.000 41.88130 ? 184 PRO A CB  1 
ATOM   1408 C CG  . PRO A 1 182 ? 22.56805 6.90537   15.22579  1.000 45.93031 ? 184 PRO A CG  1 
ATOM   1409 C CD  . PRO A 1 182 ? 21.92478 6.03157   14.18509  1.000 42.65610 ? 184 PRO A CD  1 
ATOM   1410 N N   . PHE A 1 183 ? 21.36398 3.38056   16.50197  1.000 39.15081 ? 185 PHE A N   1 
ATOM   1411 C CA  . PHE A 1 183 ? 20.38093 3.10018   17.53354  1.000 37.85650 ? 185 PHE A CA  1 
ATOM   1412 C C   . PHE A 1 183 ? 20.70159 1.82729   18.30961  1.000 42.00414 ? 185 PHE A C   1 
ATOM   1413 O O   . PHE A 1 183 ? 21.39209 0.93169   17.82168  1.000 38.72304 ? 185 PHE A O   1 
ATOM   1414 C CB  . PHE A 1 183 ? 18.99019 3.02710   16.90267  1.000 41.76441 ? 185 PHE A CB  1 
ATOM   1415 C CG  . PHE A 1 183 ? 18.66592 4.23114   16.04790  1.000 43.55108 ? 185 PHE A CG  1 
ATOM   1416 C CD1 . PHE A 1 183 ? 18.55677 5.50630   16.62738  1.000 42.09908 ? 185 PHE A CD1 1 
ATOM   1417 C CD2 . PHE A 1 183 ? 18.48114 4.10242   14.68192  1.000 39.48454 ? 185 PHE A CD2 1 
ATOM   1418 C CE1 . PHE A 1 183 ? 18.26611 6.61777   15.85758  1.000 41.42919 ? 185 PHE A CE1 1 
ATOM   1419 C CE2 . PHE A 1 183 ? 18.18645 5.21488   13.89315  1.000 42.55850 ? 185 PHE A CE2 1 
ATOM   1420 C CZ  . PHE A 1 183 ? 18.07919 6.47569   14.48908  1.000 47.04988 ? 185 PHE A CZ  1 
ATOM   1421 N N   . VAL A 1 184 ? 20.19594 1.75992   19.54562  1.000 42.40660 ? 186 VAL A N   1 
ATOM   1422 C CA  . VAL A 1 184 ? 20.39094 0.60137   20.40466  1.000 41.08121 ? 186 VAL A CA  1 
ATOM   1423 C C   . VAL A 1 184 ? 19.04850 0.13346   20.95466  1.000 42.84595 ? 186 VAL A C   1 
ATOM   1424 O O   . VAL A 1 184 ? 18.15222 0.94106   21.22385  1.000 43.06509 ? 186 VAL A O   1 
ATOM   1425 C CB  . VAL A 1 184 ? 21.38788 0.91968   21.53733  1.000 43.22111 ? 186 VAL A CB  1 
ATOM   1426 C CG1 . VAL A 1 184 ? 22.78993 1.04692   20.94620  1.000 42.70609 ? 186 VAL A CG1 1 
ATOM   1427 C CG2 . VAL A 1 184 ? 20.99673 2.20100   22.25457  1.000 45.44762 ? 186 VAL A CG2 1 
ATOM   1428 N N   . ASP A 1 185 ? 18.90926 -1.18988  21.11516  1.000 37.29930 ? 187 ASP A N   1 
ATOM   1429 C CA  . ASP A 1 185 ? 17.69800 -1.76989  21.70397  1.000 43.75663 ? 187 ASP A CA  1 
ATOM   1430 C C   . ASP A 1 185 ? 17.74105 -1.60008  23.22716  1.000 42.83641 ? 187 ASP A C   1 
ATOM   1431 O O   . ASP A 1 185 ? 17.97991 -2.53110  24.00111  1.000 40.81285 ? 187 ASP A O   1 
ATOM   1432 C CB  . ASP A 1 185 ? 17.49532 -3.23148  21.27559  1.000 41.66959 ? 187 ASP A CB  1 
ATOM   1433 C CG  . ASP A 1 185 ? 18.77181 -4.08847  21.33259  1.000 40.56397 ? 187 ASP A CG  1 
ATOM   1434 O OD1 . ASP A 1 185 ? 19.88039 -3.57407  21.59486  1.000 42.85386 ? 187 ASP A OD1 1 
ATOM   1435 O OD2 . ASP A 1 185 ? 18.65467 -5.31305  21.11014  1.000 39.28997 ? 187 ASP A OD2 1 
ATOM   1436 N N   . ARG A 1 186 ? 17.43758 -0.37658  23.65083  1.000 45.66531 ? 188 ARG A N   1 
ATOM   1437 C CA  . ARG A 1 186 ? 17.58372 0.07985   25.02238  1.000 45.26792 ? 188 ARG A CA  1 
ATOM   1438 C C   . ARG A 1 186 ? 16.68975 1.30812   25.17265  1.000 52.61651 ? 188 ARG A C   1 
ATOM   1439 O O   . ARG A 1 186 ? 16.62786 2.14366   24.26613  1.000 52.25668 ? 188 ARG A O   1 
ATOM   1440 C CB  . ARG A 1 186 ? 19.06467 0.39565   25.32420  1.000 44.46259 ? 188 ARG A CB  1 
ATOM   1441 C CG  . ARG A 1 186 ? 19.35074 1.17001   26.58883  1.000 55.89462 ? 188 ARG A CG  1 
ATOM   1442 C CD  . ARG A 1 186 ? 20.82109 1.62843   26.68377  1.000 61.17354 ? 188 ARG A CD  1 
ATOM   1443 N NE  . ARG A 1 186 ? 21.72899 0.75469   25.93719  1.000 57.39004 ? 188 ARG A NE  1 
ATOM   1444 C CZ  . ARG A 1 186 ? 22.93611 1.12407   25.50329  1.000 59.44478 ? 188 ARG A CZ  1 
ATOM   1445 N NH1 . ARG A 1 186 ? 23.37614 2.35911   25.74802  1.000 62.34871 ? 188 ARG A NH1 1 
ATOM   1446 N NH2 . ARG A 1 186 ? 23.70334 0.26743   24.82157  1.000 51.95336 ? 188 ARG A NH2 1 
ATOM   1447 N N   . GLN A 1 187 ? 15.95683 1.38786   26.28607  1.000 56.03673 ? 189 GLN A N   1 
ATOM   1448 C CA  . GLN A 1 187 ? 15.13264 2.56385   26.58478  1.000 51.65300 ? 189 GLN A CA  1 
ATOM   1449 C C   . GLN A 1 187 ? 16.05124 3.63384   27.13193  1.000 54.79718 ? 189 GLN A C   1 
ATOM   1450 O O   . GLN A 1 187 ? 16.32195 3.71913   28.33245  1.000 54.44963 ? 189 GLN A O   1 
ATOM   1451 C CB  . GLN A 1 187 ? 14.03043 2.24238   27.57443  1.000 51.53147 ? 189 GLN A CB  1 
ATOM   1452 C CG  . GLN A 1 187 ? 13.00098 3.32230   27.71182  1.000 44.74242 ? 189 GLN A CG  1 
ATOM   1453 C CD  . GLN A 1 187 ? 11.77198 2.83323   28.44647  1.000 51.46817 ? 189 GLN A CD  1 
ATOM   1454 O OE1 . GLN A 1 187 ? 11.19613 1.79993   28.10003  1.000 52.01434 ? 189 GLN A OE1 1 
ATOM   1455 N NE2 . GLN A 1 187 ? 11.37181 3.56093   29.47621  1.000 52.55255 ? 189 GLN A NE2 1 
ATOM   1456 N N   . THR A 1 188 ? 16.53540 4.46103   26.22440  1.000 56.88170 ? 190 THR A N   1 
ATOM   1457 C CA  . THR A 1 188 ? 17.56746 5.41678   26.54433  1.000 56.52121 ? 190 THR A CA  1 
ATOM   1458 C C   . THR A 1 188 ? 17.36299 6.58099   25.60040  1.000 57.10971 ? 190 THR A C   1 
ATOM   1459 O O   . THR A 1 188 ? 16.63854 6.47196   24.60894  1.000 50.78330 ? 190 THR A O   1 
ATOM   1460 C CB  . THR A 1 188 ? 18.95222 4.77707   26.39838  1.000 56.19257 ? 190 THR A CB  1 
ATOM   1461 O OG1 . THR A 1 188 ? 19.88843 5.44620   27.23903  1.000 59.31566 ? 190 THR A OG1 1 
ATOM   1462 C CG2 . THR A 1 188 ? 19.41818 4.82575   24.94616  1.000 60.45686 ? 190 THR A CG2 1 
ATOM   1463 N N   . ALA A 1 189 ? 17.97239 7.70753   25.93622  1.000 62.93119 ? 191 ALA A N   1 
ATOM   1464 C CA  . ALA A 1 189 ? 17.82094 8.89919   25.11537  1.000 59.88146 ? 191 ALA A CA  1 
ATOM   1465 C C   . ALA A 1 189 ? 18.54176 8.68318   23.78777  1.000 56.16810 ? 191 ALA A C   1 
ATOM   1466 O O   . ALA A 1 189 ? 19.77084 8.57148   23.75318  1.000 60.34491 ? 191 ALA A O   1 
ATOM   1467 C CB  . ALA A 1 189 ? 18.35870 10.11190  25.87116  1.000 63.38676 ? 191 ALA A CB  1 
ATOM   1468 N N   . GLN A 1 190 ? 17.78696 8.59870   22.69148  1.000 52.53236 ? 192 GLN A N   1 
ATOM   1469 C CA  . GLN A 1 190 ? 18.37429 8.39544   21.37377  1.000 54.71460 ? 192 GLN A CA  1 
ATOM   1470 C C   . GLN A 1 190 ? 17.81307 9.41182   20.40671  1.000 47.51726 ? 192 GLN A C   1 
ATOM   1471 O O   . GLN A 1 190 ? 16.60551 9.64679   20.37239  1.000 50.68333 ? 192 GLN A O   1 
ATOM   1472 C CB  . GLN A 1 190 ? 18.10047 6.99447   20.81911  1.000 49.02332 ? 192 GLN A CB  1 
ATOM   1473 C CG  . GLN A 1 190 ? 18.62592 5.86916   21.65899  1.000 53.07751 ? 192 GLN A CG  1 
ATOM   1474 C CD  . GLN A 1 190 ? 18.42179 4.52918   20.98916  1.000 49.34355 ? 192 GLN A CD  1 
ATOM   1475 O OE1 . GLN A 1 190 ? 19.11521 4.20199   20.03926  1.000 46.81821 ? 192 GLN A OE1 1 
ATOM   1476 N NE2 . GLN A 1 190 ? 17.46486 3.75101   21.47860  1.000 48.05828 ? 192 GLN A NE2 1 
ATOM   1477 N N   . ALA A 1 191 ? 18.68712 9.97606   19.59316  1.000 50.65154 ? 193 ALA A N   1 
ATOM   1478 C CA  . ALA A 1 191 ? 18.29871 10.98070  18.61822  1.000 56.57443 ? 193 ALA A CA  1 
ATOM   1479 C C   . ALA A 1 191 ? 18.69633 10.52290  17.22279  1.000 51.94487 ? 193 ALA A C   1 
ATOM   1480 O O   . ALA A 1 191 ? 19.83062 10.08372  17.00321  1.000 48.98514 ? 193 ALA A O   1 
ATOM   1481 C CB  . ALA A 1 191 ? 18.94712 12.32786  18.94360  1.000 57.24521 ? 193 ALA A CB  1 
ATOM   1482 N N   . ALA A 1 192 ? 17.75712 10.60456  16.28907  1.000 56.18384 ? 194 ALA A N   1 
ATOM   1483 C CA  . ALA A 1 192 ? 18.12021 10.51633  14.88675  1.000 49.82998 ? 194 ALA A CA  1 
ATOM   1484 C C   . ALA A 1 192 ? 18.83266 11.79531  14.46993  1.000 58.00866 ? 194 ALA A C   1 
ATOM   1485 O O   . ALA A 1 192 ? 18.67403 12.85773  15.08103  1.000 57.87556 ? 194 ALA A O   1 
ATOM   1486 C CB  . ALA A 1 192 ? 16.88641 10.29912  14.01909  1.000 44.38452 ? 194 ALA A CB  1 
ATOM   1487 N N   . GLY A 1 193 ? 19.63830 11.68771  13.42704  1.000 57.40798 ? 195 GLY A N   1 
ATOM   1488 C CA  . GLY A 1 193 ? 20.25261 12.86882  12.87515  1.000 57.25665 ? 195 GLY A CA  1 
ATOM   1489 C C   . GLY A 1 193 ? 19.21347 13.78261  12.25316  1.000 58.25087 ? 195 GLY A C   1 
ATOM   1490 O O   . GLY A 1 193 ? 18.02053 13.48247  12.18165  1.000 58.51955 ? 195 GLY A O   1 
ATOM   1491 N N   . THR A 1 194 ? 19.68248 14.93363  11.79069  1.000 56.88866 ? 196 THR A N   1 
ATOM   1492 C CA  . THR A 1 194 ? 18.83651 15.74058  10.92849  1.000 56.19139 ? 196 THR A CA  1 
ATOM   1493 C C   . THR A 1 194 ? 18.51688 14.94677  9.66562   1.000 50.49967 ? 196 THR A C   1 
ATOM   1494 O O   . THR A 1 194 ? 19.39251 14.30039  9.08317   1.000 49.80344 ? 196 THR A O   1 
ATOM   1495 C CB  . THR A 1 194 ? 19.52830 17.05155  10.59369  1.000 53.93081 ? 196 THR A CB  1 
ATOM   1496 O OG1 . THR A 1 194 ? 20.92579 16.79744  10.45473  1.000 57.78564 ? 196 THR A OG1 1 
ATOM   1497 C CG2 . THR A 1 194 ? 19.31786 18.05515  11.71818  1.000 57.29446 ? 196 THR A CG2 1 
ATOM   1498 N N   . ASP A 1 195 ? 17.25151 14.98339  9.25857   1.000 51.37581 ? 197 ASP A N   1 
ATOM   1499 C CA  . ASP A 1 195 ? 16.73799 14.16156  8.17076   1.000 50.51329 ? 197 ASP A CA  1 
ATOM   1500 C C   . ASP A 1 195 ? 16.65914 14.97694  6.88251   1.000 51.53666 ? 197 ASP A C   1 
ATOM   1501 O O   . ASP A 1 195 ? 15.89169 15.93823  6.78903   1.000 60.40363 ? 197 ASP A O   1 
ATOM   1502 C CB  . ASP A 1 195 ? 15.36702 13.59225  8.54424   1.000 52.42683 ? 197 ASP A CB  1 
ATOM   1503 C CG  . ASP A 1 195 ? 14.79277 12.67079  7.47013   1.000 57.03195 ? 197 ASP A CG  1 
ATOM   1504 O OD1 . ASP A 1 195 ? 13.54801 12.69125  7.26127   1.000 56.20908 ? 197 ASP A OD1 1 
ATOM   1505 O OD2 . ASP A 1 195 ? 15.59141 11.94320  6.83391   1.000 49.46430 ? 197 ASP A OD2 1 
ATOM   1506 N N   . THR A 1 196 ? 17.42351 14.55987  5.88578   1.000 49.06031 ? 198 THR A N   1 
ATOM   1507 C CA  . THR A 1 196 ? 17.52107 15.23482  4.60156   1.000 49.96144 ? 198 THR A CA  1 
ATOM   1508 C C   . THR A 1 196 ? 16.51166 14.66178  3.58508   1.000 49.73597 ? 198 THR A C   1 
ATOM   1509 O O   . THR A 1 196 ? 15.80191 13.68259  3.83118   1.000 45.76295 ? 198 THR A O   1 
ATOM   1510 C CB  . THR A 1 196 ? 18.96470 15.14873  4.07681   1.000 51.24982 ? 198 THR A CB  1 
ATOM   1511 O OG1 . THR A 1 196 ? 19.35540 13.78501  3.90221   1.000 52.27918 ? 198 THR A OG1 1 
ATOM   1512 C CG2 . THR A 1 196 ? 19.92700 15.76338  5.07853   1.000 58.09869 ? 198 THR A CG2 1 
ATOM   1513 N N   . THR A 1 197 ? 16.46005 15.26386  2.40389   1.000 46.81453 ? 199 THR A N   1 
ATOM   1514 C CA  . THR A 1 197 ? 15.52192 14.85279  1.36834   1.000 47.11341 ? 199 THR A CA  1 
ATOM   1515 C C   . THR A 1 197 ? 16.27821 14.11754  0.26895   1.000 44.85441 ? 199 THR A C   1 
ATOM   1516 O O   . THR A 1 197 ? 17.30939 14.59904  -0.20226  1.000 47.36952 ? 199 THR A O   1 
ATOM   1517 C CB  . THR A 1 197 ? 14.75478 16.06643  0.82426   1.000 45.22170 ? 199 THR A CB  1 
ATOM   1518 O OG1 . THR A 1 197 ? 13.89356 16.55587  1.86031   1.000 45.75477 ? 199 THR A OG1 1 
ATOM   1519 C CG2 . THR A 1 197 ? 13.87601 15.69545  -0.37467  1.000 36.69288 ? 199 THR A CG2 1 
ATOM   1520 N N   . ILE A 1 198 ? 15.78109 12.93256  -0.10017  1.000 43.16204 ? 200 ILE A N   1 
ATOM   1521 C CA  . ILE A 1 198 ? 16.38453 12.07885  -1.12307  1.000 41.89953 ? 200 ILE A CA  1 
ATOM   1522 C C   . ILE A 1 198 ? 16.17094 12.67599  -2.51262  1.000 41.49200 ? 200 ILE A C   1 
ATOM   1523 O O   . ILE A 1 198 ? 15.14238 12.43884  -3.15884  1.000 42.05751 ? 200 ILE A O   1 
ATOM   1524 C CB  . ILE A 1 198 ? 15.80156 10.65746  -1.04857  1.000 39.09592 ? 200 ILE A CB  1 
ATOM   1525 C CG1 . ILE A 1 198 ? 15.70889 10.19571  0.40940   1.000 43.04028 ? 200 ILE A CG1 1 
ATOM   1526 C CG2 . ILE A 1 198 ? 16.62751 9.68282   -1.86265  1.000 36.94112 ? 200 ILE A CG2 1 
ATOM   1527 C CD1 . ILE A 1 198 ? 14.62973 9.10164   0.65951   1.000 38.03701 ? 200 ILE A CD1 1 
ATOM   1528 N N   . THR A 1 199 ? 17.16646 13.41938  -2.99328  1.000 40.25429 ? 201 THR A N   1 
ATOM   1529 C CA  . THR A 1 199 ? 17.02892 14.18499  -4.22665  1.000 36.30737 ? 201 THR A CA  1 
ATOM   1530 C C   . THR A 1 199 ? 16.72800 13.28824  -5.42248  1.000 38.40704 ? 201 THR A C   1 
ATOM   1531 O O   . THR A 1 199 ? 15.81221 13.56611  -6.21182  1.000 43.84141 ? 201 THR A O   1 
ATOM   1532 C CB  . THR A 1 199 ? 18.31121 14.97285  -4.46363  1.000 41.03494 ? 201 THR A CB  1 
ATOM   1533 O OG1 . THR A 1 199 ? 18.72977 15.57791  -3.22844  1.000 43.64664 ? 201 THR A OG1 1 
ATOM   1534 C CG2 . THR A 1 199 ? 18.09707 16.03118  -5.52455  1.000 39.91142 ? 201 THR A CG2 1 
ATOM   1535 N N   . VAL A 1 200 ? 17.50678 12.22125  -5.59627  1.000 34.19903 ? 202 VAL A N   1 
ATOM   1536 C CA  . VAL A 1 200 ? 17.29684 11.35234  -6.75122  1.000 35.90904 ? 202 VAL A CA  1 
ATOM   1537 C C   . VAL A 1 200 ? 15.86332 10.82746  -6.76990  1.000 34.03128 ? 202 VAL A C   1 
ATOM   1538 O O   . VAL A 1 200 ? 15.24267 10.72461  -7.83456  1.000 35.13409 ? 202 VAL A O   1 
ATOM   1539 C CB  . VAL A 1 200 ? 18.34357 10.21474  -6.77589  1.000 40.96098 ? 202 VAL A CB  1 
ATOM   1540 C CG1 . VAL A 1 200 ? 18.11623 9.19562   -5.63081  1.000 36.23165 ? 202 VAL A CG1 1 
ATOM   1541 C CG2 . VAL A 1 200 ? 18.35811 9.52544   -8.13870  1.000 36.10120 ? 202 VAL A CG2 1 
ATOM   1542 N N   . ASN A 1 201 ? 15.29760 10.54191  -5.59116  1.000 33.21869 ? 203 ASN A N   1 
ATOM   1543 C CA  . ASN A 1 201 ? 13.90393 10.10541  -5.51859  1.000 34.13450 ? 203 ASN A CA  1 
ATOM   1544 C C   . ASN A 1 201 ? 12.93581 11.22123  -5.89708  1.000 37.54603 ? 203 ASN A C   1 
ATOM   1545 O O   . ASN A 1 201 ? 11.95602 10.96706  -6.59868  1.000 37.76268 ? 203 ASN A O   1 
ATOM   1546 C CB  . ASN A 1 201 ? 13.57710 9.59771   -4.12323  1.000 37.57044 ? 203 ASN A CB  1 
ATOM   1547 C CG  . ASN A 1 201 ? 14.21875 8.26528   -3.82301  1.000 38.36076 ? 203 ASN A CG  1 
ATOM   1548 O OD1 . ASN A 1 201 ? 14.89241 7.67608   -4.67329  1.000 36.56007 ? 203 ASN A OD1 1 
ATOM   1549 N ND2 . ASN A 1 201 ? 14.01819 7.78230   -2.60898  1.000 31.72983 ? 203 ASN A ND2 1 
ATOM   1550 N N   . VAL A 1 202 ? 13.17309 12.46444  -5.44875  1.000 38.21156 ? 204 VAL A N   1 
ATOM   1551 C CA  . VAL A 1 202 ? 12.27024 13.54799  -5.85273  1.000 36.40556 ? 204 VAL A CA  1 
ATOM   1552 C C   . VAL A 1 202 ? 12.32369 13.73783  -7.36152  1.000 38.13287 ? 204 VAL A C   1 
ATOM   1553 O O   . VAL A 1 202 ? 11.28970 13.93492  -8.01070  1.000 37.27525 ? 204 VAL A O   1 
ATOM   1554 C CB  . VAL A 1 202 ? 12.59370 14.86276  -5.11659  1.000 40.42441 ? 204 VAL A CB  1 
ATOM   1555 C CG1 . VAL A 1 202 ? 11.85392 16.01713  -5.74281  1.000 36.87614 ? 204 VAL A CG1 1 
ATOM   1556 C CG2 . VAL A 1 202 ? 12.24459 14.77047  -3.65024  1.000 40.45194 ? 204 VAL A CG2 1 
ATOM   1557 N N   . LEU A 1 203 ? 13.51936 13.64627  -7.95350  1.000 38.60239 ? 205 LEU A N   1 
ATOM   1558 C CA  . LEU A 1 203 ? 13.60678 13.77217  -9.41180  1.000 41.38610 ? 205 LEU A CA  1 
ATOM   1559 C C   . LEU A 1 203 ? 12.81749 12.67337  -10.11751 1.000 39.61066 ? 205 LEU A C   1 
ATOM   1560 O O   . LEU A 1 203 ? 12.15993 12.93245  -11.13285 1.000 42.18492 ? 205 LEU A O   1 
ATOM   1561 C CB  . LEU A 1 203 ? 15.06848 13.76107  -9.88016  1.000 38.55541 ? 205 LEU A CB  1 
ATOM   1562 C CG  . LEU A 1 203 ? 15.90406 14.96611  -9.45486  1.000 37.62598 ? 205 LEU A CG  1 
ATOM   1563 C CD1 . LEU A 1 203 ? 17.37805 14.68278  -9.67960  1.000 37.81499 ? 205 LEU A CD1 1 
ATOM   1564 C CD2 . LEU A 1 203 ? 15.45704 16.21217  -10.17881 1.000 42.14549 ? 205 LEU A CD2 1 
ATOM   1565 N N   . ALA A 1 204 ? 12.87792 11.43558  -9.60801  1.000 37.74104 ? 206 ALA A N   1 
ATOM   1566 C CA  . ALA A 1 204 ? 12.10960 10.35084  -10.21858 1.000 38.05322 ? 206 ALA A CA  1 
ATOM   1567 C C   . ALA A 1 204 ? 10.60693 10.62682  -10.14709 1.000 35.54504 ? 206 ALA A C   1 
ATOM   1568 O O   . ALA A 1 204 ? 9.86860  10.37922  -11.10841 1.000 40.06291 ? 206 ALA A O   1 
ATOM   1569 C CB  . ALA A 1 204 ? 12.45845 9.01833   -9.54158  1.000 36.67986 ? 206 ALA A CB  1 
ATOM   1570 N N   . TRP A 1 205 ? 10.14347 11.14498  -9.01629  1.000 33.41175 ? 207 TRP A N   1 
ATOM   1571 C CA  . TRP A 1 205 ? 8.73632  11.47987  -8.85072  1.000 39.59072 ? 207 TRP A CA  1 
ATOM   1572 C C   . TRP A 1 205 ? 8.31508  12.60874  -9.78509  1.000 41.08815 ? 207 TRP A C   1 
ATOM   1573 O O   . TRP A 1 205 ? 7.16128  12.65541  -10.23604 1.000 41.33152 ? 207 TRP A O   1 
ATOM   1574 C CB  . TRP A 1 205 ? 8.49827  11.84098  -7.38291  1.000 40.42615 ? 207 TRP A CB  1 
ATOM   1575 C CG  . TRP A 1 205 ? 7.12478  12.27681  -7.02230  1.000 43.84125 ? 207 TRP A CG  1 
ATOM   1576 C CD1 . TRP A 1 205 ? 6.02141  11.48509  -6.84985  1.000 38.90476 ? 207 TRP A CD1 1 
ATOM   1577 C CD2 . TRP A 1 205 ? 6.70858  13.61468  -6.74022  1.000 42.80175 ? 207 TRP A CD2 1 
ATOM   1578 N NE1 . TRP A 1 205 ? 4.94317  12.25928  -6.49729  1.000 41.34208 ? 207 TRP A NE1 1 
ATOM   1579 C CE2 . TRP A 1 205 ? 5.33983  13.56980  -6.42733  1.000 42.40876 ? 207 TRP A CE2 1 
ATOM   1580 C CE3 . TRP A 1 205 ? 7.35816  14.84739  -6.73483  1.000 44.63051 ? 207 TRP A CE3 1 
ATOM   1581 C CZ2 . TRP A 1 205 ? 4.61377  14.71168  -6.10247  1.000 46.45655 ? 207 TRP A CZ2 1 
ATOM   1582 C CZ3 . TRP A 1 205 ? 6.62514  15.98368  -6.42223  1.000 46.89885 ? 207 TRP A CZ3 1 
ATOM   1583 C CH2 . TRP A 1 205 ? 5.27208  15.90604  -6.11631  1.000 45.15047 ? 207 TRP A CH2 1 
ATOM   1584 N N   . LEU A 1 206 ? 9.23103  13.52363  -10.09192 1.000 41.81958 ? 208 LEU A N   1 
ATOM   1585 C CA  . LEU A 1 206 ? 8.94150  14.52260  -11.11057 1.000 42.92635 ? 208 LEU A CA  1 
ATOM   1586 C C   . LEU A 1 206 ? 8.78730  13.86975  -12.47452 1.000 42.70345 ? 208 LEU A C   1 
ATOM   1587 O O   . LEU A 1 206 ? 7.91071  14.24957  -13.25384 1.000 41.70972 ? 208 LEU A O   1 
ATOM   1588 C CB  . LEU A 1 206 ? 10.04431 15.57029  -11.12598 1.000 38.53974 ? 208 LEU A CB  1 
ATOM   1589 C CG  . LEU A 1 206 ? 10.00176 16.38776  -9.85175  1.000 39.90398 ? 208 LEU A CG  1 
ATOM   1590 C CD1 . LEU A 1 206 ? 11.22313 17.26198  -9.76042  1.000 46.98988 ? 208 LEU A CD1 1 
ATOM   1591 C CD2 . LEU A 1 206 ? 8.73410  17.22066  -9.78363  1.000 44.81147 ? 208 LEU A CD2 1 
ATOM   1592 N N   . TYR A 1 207 ? 9.61730  12.86612  -12.76773 1.000 41.60241 ? 209 TYR A N   1 
ATOM   1593 C CA  . TYR A 1 207 ? 9.49849  12.15703  -14.03184 1.000 38.53456 ? 209 TYR A CA  1 
ATOM   1594 C C   . TYR A 1 207 ? 8.17173  11.41650  -14.10717 1.000 43.91664 ? 209 TYR A C   1 
ATOM   1595 O O   . TYR A 1 207 ? 7.49065  11.44169  -15.14032 1.000 42.76265 ? 209 TYR A O   1 
ATOM   1596 C CB  . TYR A 1 207 ? 10.67815 11.19453  -14.20743 1.000 39.23190 ? 209 TYR A CB  1 
ATOM   1597 C CG  . TYR A 1 207 ? 11.89593 11.82556  -14.84175 1.000 42.00205 ? 209 TYR A CG  1 
ATOM   1598 C CD1 . TYR A 1 207 ? 11.90355 12.19821  -16.19169 1.000 49.14531 ? 209 TYR A CD1 1 
ATOM   1599 C CD2 . TYR A 1 207 ? 13.02293 12.07130  -14.09924 1.000 41.97694 ? 209 TYR A CD2 1 
ATOM   1600 C CE1 . TYR A 1 207 ? 13.02363 12.78733  -16.77836 1.000 46.10057 ? 209 TYR A CE1 1 
ATOM   1601 C CE2 . TYR A 1 207 ? 14.13470 12.65761  -14.66515 1.000 49.86911 ? 209 TYR A CE2 1 
ATOM   1602 C CZ  . TYR A 1 207 ? 14.13625 13.01547  -16.00066 1.000 51.98844 ? 209 TYR A CZ  1 
ATOM   1603 O OH  . TYR A 1 207 ? 15.26587 13.59229  -16.53602 1.000 51.31558 ? 209 TYR A OH  1 
ATOM   1604 N N   . ALA A 1 208 ? 7.79919  10.72758  -13.02137 1.000 45.70829 ? 210 ALA A N   1 
ATOM   1605 C CA  . ALA A 1 208 ? 6.49509  10.07195  -12.97185 1.000 42.40009 ? 210 ALA A CA  1 
ATOM   1606 C C   . ALA A 1 208 ? 5.39889  11.06427  -13.29816 1.000 47.13036 ? 210 ALA A C   1 
ATOM   1607 O O   . ALA A 1 208 ? 4.53498  10.79837  -14.14298 1.000 45.42084 ? 210 ALA A O   1 
ATOM   1608 C CB  . ALA A 1 208 ? 6.25166  9.46263   -11.59276 1.000 38.83619 ? 210 ALA A CB  1 
ATOM   1609 N N   . ALA A 1 209 ? 5.44258  12.22803  -12.62847 1.000 45.46628 ? 211 ALA A N   1 
ATOM   1610 C CA  . ALA A 1 209 ? 4.54245  13.34188  -12.90818 1.000 44.59550 ? 211 ALA A CA  1 
ATOM   1611 C C   . ALA A 1 209 ? 4.49424  13.66938  -14.39369 1.000 45.99852 ? 211 ALA A C   1 
ATOM   1612 O O   . ALA A 1 209 ? 3.41468  13.78052  -14.98340 1.000 50.23883 ? 211 ALA A O   1 
ATOM   1613 C CB  . ALA A 1 209 ? 4.98023  14.57179  -12.11224 1.000 42.58941 ? 211 ALA A CB  1 
ATOM   1614 N N   . VAL A 1 210 ? 5.65335  13.83395  -15.02142 1.000 43.44627 ? 212 VAL A N   1 
ATOM   1615 C CA  . VAL A 1 210 ? 5.64260  14.14908  -16.44750 1.000 50.40084 ? 212 VAL A CA  1 
ATOM   1616 C C   . VAL A 1 210 ? 5.03948  12.99549  -17.24225 1.000 46.32053 ? 212 VAL A C   1 
ATOM   1617 O O   . VAL A 1 210 ? 4.25073  13.20419  -18.17274 1.000 47.51463 ? 212 VAL A O   1 
ATOM   1618 C CB  . VAL A 1 210 ? 7.06118  14.49878  -16.92717 1.000 46.20507 ? 212 VAL A CB  1 
ATOM   1619 C CG1 . VAL A 1 210 ? 7.11253  14.49349  -18.43796 1.000 41.66662 ? 212 VAL A CG1 1 
ATOM   1620 C CG2 . VAL A 1 210 ? 7.47994  15.84132  -16.35700 1.000 44.73932 ? 212 VAL A CG2 1 
ATOM   1621 N N   . ILE A 1 211 ? 5.37367  11.75890  -16.86700 1.000 48.26312 ? 213 ILE A N   1 
ATOM   1622 C CA  . ILE A 1 211 ? 4.84636  10.59815  -17.57927 1.000 48.65938 ? 213 ILE A CA  1 
ATOM   1623 C C   . ILE A 1 211 ? 3.32730  10.56886  -17.50361 1.000 47.62404 ? 213 ILE A C   1 
ATOM   1624 O O   . ILE A 1 211 ? 2.65923  10.13352  -18.44678 1.000 54.39312 ? 213 ILE A O   1 
ATOM   1625 C CB  . ILE A 1 211 ? 5.48428  9.31381   -17.01854 1.000 46.16520 ? 213 ILE A CB  1 
ATOM   1626 C CG1 . ILE A 1 211 ? 6.87936  9.11152   -17.61659 1.000 44.67162 ? 213 ILE A CG1 1 
ATOM   1627 C CG2 . ILE A 1 211 ? 4.59873  8.11708   -17.28807 1.000 45.08743 ? 213 ILE A CG2 1 
ATOM   1628 C CD1 . ILE A 1 211 ? 7.70750  8.07418   -16.88711 1.000 47.25776 ? 213 ILE A CD1 1 
ATOM   1629 N N   . ASN A 1 212 ? 2.75500  11.07046  -16.40764 1.000 47.78321 ? 214 ASN A N   1 
ATOM   1630 C CA  . ASN A 1 212 ? 1.31141  11.13074  -16.21546 1.000 51.19669 ? 214 ASN A CA  1 
ATOM   1631 C C   . ASN A 1 212 ? 0.72724  12.49895  -16.57084 1.000 54.83682 ? 214 ASN A C   1 
ATOM   1632 O O   . ASN A 1 212 ? -0.21598 12.95890  -15.91342 1.000 54.87945 ? 214 ASN A O   1 
ATOM   1633 C CB  . ASN A 1 212 ? 0.95362  10.76378  -14.77505 1.000 47.29815 ? 214 ASN A CB  1 
ATOM   1634 C CG  . ASN A 1 212 ? 1.11215  9.28477   -14.50089 1.000 57.36072 ? 214 ASN A CG  1 
ATOM   1635 O OD1 . ASN A 1 212 ? 0.94720  8.82671   -13.37184 1.000 61.97258 ? 214 ASN A OD1 1 
ATOM   1636 N ND2 . ASN A 1 212 ? 1.43168  8.52257   -15.54131 1.000 60.99913 ? 214 ASN A ND2 1 
ATOM   1637 N N   . GLY A 1 213 ? 1.27953  13.17052  -17.58453 1.000 51.93994 ? 215 GLY A N   1 
ATOM   1638 C CA  . GLY A 1 213 ? 0.65822  14.36256  -18.13548 1.000 56.86953 ? 215 GLY A CA  1 
ATOM   1639 C C   . GLY A 1 213 ? 0.69214  15.61592  -17.27750 1.000 58.84019 ? 215 GLY A C   1 
ATOM   1640 O O   . GLY A 1 213 ? 0.19099  16.65603  -17.71752 1.000 63.76751 ? 215 GLY A O   1 
ATOM   1641 N N   . ASP A 1 214 ? 1.26317  15.57357  -16.08114 1.000 58.47018 ? 216 ASP A N   1 
ATOM   1642 C CA  . ASP A 1 214 ? 1.37265  16.75273  -15.22357 1.000 56.07549 ? 216 ASP A CA  1 
ATOM   1643 C C   . ASP A 1 214 ? 2.75295  17.38134  -15.43248 1.000 55.98615 ? 216 ASP A C   1 
ATOM   1644 O O   . ASP A 1 214 ? 3.75984  16.84373  -14.95844 1.000 56.39976 ? 216 ASP A O   1 
ATOM   1645 C CB  . ASP A 1 214 ? 1.13739  16.35317  -13.76761 1.000 52.80803 ? 216 ASP A CB  1 
ATOM   1646 C CG  . ASP A 1 214 ? 1.27132  17.51580  -12.81250 1.000 60.95446 ? 216 ASP A CG  1 
ATOM   1647 O OD1 . ASP A 1 214 ? 0.37541  18.38605  -12.77799 1.000 62.32179 ? 216 ASP A OD1 1 
ATOM   1648 O OD2 . ASP A 1 214 ? 2.27984  17.55916  -12.08717 1.000 64.50170 ? 216 ASP A OD2 1 
ATOM   1649 N N   . ARG A 1 215 ? 2.80877  18.51914  -16.14680 1.000 53.84153 ? 217 ARG A N   1 
ATOM   1650 C CA  . ARG A 1 215 ? 4.08608  19.06425  -16.60238 1.000 52.65036 ? 217 ARG A CA  1 
ATOM   1651 C C   . ARG A 1 215 ? 4.29729  20.55045  -16.33184 1.000 55.12629 ? 217 ARG A C   1 
ATOM   1652 O O   . ARG A 1 215 ? 5.25214  21.12315  -16.87826 1.000 56.86175 ? 217 ARG A O   1 
ATOM   1653 C CB  . ARG A 1 215 ? 4.26790  18.86255  -18.11039 1.000 54.63069 ? 217 ARG A CB  1 
ATOM   1654 C CG  . ARG A 1 215 ? 3.67793  17.60883  -18.68233 1.000 60.96210 ? 217 ARG A CG  1 
ATOM   1655 C CD  . ARG A 1 215 ? 3.63780  17.69647  -20.20345 1.000 60.28008 ? 217 ARG A CD  1 
ATOM   1656 N NE  . ARG A 1 215 ? 4.71282  18.53473  -20.72454 1.000 56.87857 ? 217 ARG A NE  1 
ATOM   1657 C CZ  . ARG A 1 215 ? 5.83014  18.05839  -21.26401 1.000 60.46500 ? 217 ARG A CZ  1 
ATOM   1658 N NH1 . ARG A 1 215 ? 6.75438  18.89842  -21.71694 1.000 62.77525 ? 217 ARG A NH1 1 
ATOM   1659 N NH2 . ARG A 1 215 ? 6.02307  16.74272  -21.35636 1.000 53.63367 ? 217 ARG A NH2 1 
ATOM   1660 N N   . TRP A 1 216 ? 3.45167  21.20127  -15.52903 1.000 56.13511 ? 218 TRP A N   1 
ATOM   1661 C CA  . TRP A 1 216 ? 3.50296  22.66340  -15.45995 1.000 50.29707 ? 218 TRP A CA  1 
ATOM   1662 C C   . TRP A 1 216 ? 4.86572  23.17290  -15.01400 1.000 58.36756 ? 218 TRP A C   1 
ATOM   1663 O O   . TRP A 1 216 ? 5.32653  24.21267  -15.49620 1.000 61.68854 ? 218 TRP A O   1 
ATOM   1664 C CB  . TRP A 1 216 ? 2.41067  23.19608  -14.53715 1.000 49.97145 ? 218 TRP A CB  1 
ATOM   1665 C CG  . TRP A 1 216 ? 2.41239  22.65208  -13.14104 1.000 58.62165 ? 218 TRP A CG  1 
ATOM   1666 C CD1 . TRP A 1 216 ? 1.64899  21.62123  -12.65502 1.000 63.39041 ? 218 TRP A CD1 1 
ATOM   1667 C CD2 . TRP A 1 216 ? 3.18598  23.12912  -12.03359 1.000 61.42730 ? 218 TRP A CD2 1 
ATOM   1668 N NE1 . TRP A 1 216 ? 1.91676  21.41575  -11.31242 1.000 64.63501 ? 218 TRP A NE1 1 
ATOM   1669 C CE2 . TRP A 1 216 ? 2.85487  22.32927  -10.90928 1.000 63.58542 ? 218 TRP A CE2 1 
ATOM   1670 C CE3 . TRP A 1 216 ? 4.13576  24.14074  -11.88345 1.000 59.13774 ? 218 TRP A CE3 1 
ATOM   1671 C CZ2 . TRP A 1 216 ? 3.43055  22.52581  -9.65927  1.000 60.67380 ? 218 TRP A CZ2 1 
ATOM   1672 C CZ3 . TRP A 1 216 ? 4.70789  24.32968  -10.64163 1.000 61.96045 ? 218 TRP A CZ3 1 
ATOM   1673 C CH2 . TRP A 1 216 ? 4.35357  23.52555  -9.54515  1.000 60.29053 ? 218 TRP A CH2 1 
ATOM   1674 N N   . PHE A 1 217 ? 5.54015  22.44094  -14.13134 1.000 58.13314 ? 219 PHE A N   1 
ATOM   1675 C CA  . PHE A 1 217 ? 6.80826  22.86460  -13.55062 1.000 55.88791 ? 219 PHE A CA  1 
ATOM   1676 C C   . PHE A 1 217 ? 7.99178  22.70315  -14.48882 1.000 54.76053 ? 219 PHE A C   1 
ATOM   1677 O O   . PHE A 1 217 ? 9.10883  23.08745  -14.11825 1.000 54.88019 ? 219 PHE A O   1 
ATOM   1678 C CB  . PHE A 1 217 ? 7.08511  22.05807  -12.28542 1.000 58.15720 ? 219 PHE A CB  1 
ATOM   1679 C CG  . PHE A 1 217 ? 7.06907  20.57826  -12.51376 1.000 54.58819 ? 219 PHE A CG  1 
ATOM   1680 C CD1 . PHE A 1 217 ? 8.23422  19.90604  -12.82278 1.000 50.30580 ? 219 PHE A CD1 1 
ATOM   1681 C CD2 . PHE A 1 217 ? 5.87924  19.86493  -12.44438 1.000 53.68778 ? 219 PHE A CD2 1 
ATOM   1682 C CE1 . PHE A 1 217 ? 8.21410  18.53838  -13.04121 1.000 54.24779 ? 219 PHE A CE1 1 
ATOM   1683 C CE2 . PHE A 1 217 ? 5.85511  18.50855  -12.65476 1.000 47.99116 ? 219 PHE A CE2 1 
ATOM   1684 C CZ  . PHE A 1 217 ? 7.01852  17.84317  -12.96051 1.000 46.04678 ? 219 PHE A CZ  1 
ATOM   1685 N N   . LEU A 1 218 ? 7.80471  22.09457  -15.65512 1.000 55.58565 ? 220 LEU A N   1 
ATOM   1686 C CA  . LEU A 1 218 ? 8.92577  21.95324  -16.56928 1.000 57.46061 ? 220 LEU A CA  1 
ATOM   1687 C C   . LEU A 1 218 ? 9.31330  23.33401  -17.05786 1.000 63.38874 ? 220 LEU A C   1 
ATOM   1688 O O   . LEU A 1 218 ? 8.45438  24.19700  -17.25465 1.000 62.24685 ? 220 LEU A O   1 
ATOM   1689 C CB  . LEU A 1 218 ? 8.56335  21.04186  -17.73814 1.000 58.43575 ? 220 LEU A CB  1 
ATOM   1690 C CG  . LEU A 1 218 ? 8.55450  19.55152  -17.41934 1.000 57.81001 ? 220 LEU A CG  1 
ATOM   1691 C CD1 . LEU A 1 218 ? 8.01731  18.79290  -18.61407 1.000 57.25077 ? 220 LEU A CD1 1 
ATOM   1692 C CD2 . LEU A 1 218 ? 9.94482  19.05188  -17.03047 1.000 52.24983 ? 220 LEU A CD2 1 
ATOM   1693 N N   . ASN A 1 219 ? 10.60774 23.57281  -17.20109 1.000 66.32219 ? 221 ASN A N   1 
ATOM   1694 C CA  . ASN A 1 219 ? 11.00963 24.92889  -17.48118 1.000 62.44188 ? 221 ASN A CA  1 
ATOM   1695 C C   . ASN A 1 219 ? 12.00053 24.95515  -18.63049 1.000 66.45498 ? 221 ASN A C   1 
ATOM   1696 O O   . ASN A 1 219 ? 12.41703 23.92950  -19.18672 1.000 67.02734 ? 221 ASN A O   1 
ATOM   1697 C CB  . ASN A 1 219 ? 11.57992 25.63037  -16.23234 1.000 64.01051 ? 221 ASN A CB  1 
ATOM   1698 C CG  . ASN A 1 219 ? 12.97047 25.14032  -15.83525 1.000 63.78621 ? 221 ASN A CG  1 
ATOM   1699 O OD1 . ASN A 1 219 ? 13.72637 24.57013  -16.62302 1.000 66.53125 ? 221 ASN A OD1 1 
ATOM   1700 N ND2 . ASN A 1 219 ? 13.32434 25.40659  -14.59822 1.000 64.02554 ? 221 ASN A ND2 1 
ATOM   1701 N N   . ARG A 1 220 ? 12.37025 26.18750  -18.93814 1.000 68.51384 ? 222 ARG A N   1 
ATOM   1702 C CA  . ARG A 1 220 ? 13.34585 26.53449  -19.96333 1.000 69.77354 ? 222 ARG A CA  1 
ATOM   1703 C C   . ARG A 1 220 ? 14.71449 25.89831  -19.74806 1.000 72.00052 ? 222 ARG A C   1 
ATOM   1704 O O   . ARG A 1 220 ? 15.31561 25.34515  -20.68374 1.000 69.45062 ? 222 ARG A O   1 
ATOM   1705 C CB  . ARG A 1 220 ? 13.46283 28.05163  -19.94912 1.000 73.05468 ? 222 ARG A CB  1 
ATOM   1706 C CG  . ARG A 1 220 ? 13.83040 28.68087  -21.20084 1.000 74.31615 ? 222 ARG A CG  1 
ATOM   1707 C CD  . ARG A 1 220 ? 14.13238 30.11222  -20.94807 1.000 75.80196 ? 222 ARG A CD  1 
ATOM   1708 N NE  . ARG A 1 220 ? 14.46121 30.75638  -22.20223 1.000 80.93097 ? 222 ARG A NE  1 
ATOM   1709 C CZ  . ARG A 1 220 ? 15.70469 30.95711  -22.62874 1.000 74.34690 ? 222 ARG A CZ  1 
ATOM   1710 N NH1 . ARG A 1 220 ? 16.75310 30.62330  -21.87582 1.000 68.29609 ? 222 ARG A NH1 1 
ATOM   1711 N NH2 . ARG A 1 220 ? 15.90289 31.51083  -23.81112 1.000 68.74020 ? 222 ARG A NH2 1 
ATOM   1712 N N   . PHE A 1 221 ? 15.22735 25.99582  -18.54071 1.000 69.33811 ? 223 PHE A N   1 
ATOM   1713 C CA  . PHE A 1 221 ? 16.65744 26.07475  -18.36891 1.000 66.92704 ? 223 PHE A CA  1 
ATOM   1714 C C   . PHE A 1 221 ? 17.27858 24.70186  -18.24253 1.000 71.37963 ? 223 PHE A C   1 
ATOM   1715 O O   . PHE A 1 221 ? 16.60039 23.67788  -18.14117 1.000 75.48405 ? 223 PHE A O   1 
ATOM   1716 C CB  . PHE A 1 221 ? 16.97321 26.92777  -17.14917 1.000 66.88536 ? 223 PHE A CB  1 
ATOM   1717 C CG  . PHE A 1 221 ? 16.12963 28.14893  -17.06523 1.000 71.59733 ? 223 PHE A CG  1 
ATOM   1718 C CD1 . PHE A 1 221 ? 16.40646 29.24628  -17.86767 1.000 71.83521 ? 223 PHE A CD1 1 
ATOM   1719 C CD2 . PHE A 1 221 ? 15.01523 28.18085  -16.24750 1.000 67.72984 ? 223 PHE A CD2 1 
ATOM   1720 C CE1 . PHE A 1 221 ? 15.61819 30.36842  -17.81121 1.000 69.20051 ? 223 PHE A CE1 1 
ATOM   1721 C CE2 . PHE A 1 221 ? 14.21306 29.30265  -16.19508 1.000 70.42123 ? 223 PHE A CE2 1 
ATOM   1722 C CZ  . PHE A 1 221 ? 14.51571 30.39867  -16.97780 1.000 71.68394 ? 223 PHE A CZ  1 
ATOM   1723 N N   . THR A 1 222 ? 18.59175 24.69165  -18.29123 1.000 66.12941 ? 224 THR A N   1 
ATOM   1724 C CA  . THR A 1 222 ? 19.34865 23.58081  -17.77054 1.000 67.02074 ? 224 THR A CA  1 
ATOM   1725 C C   . THR A 1 222 ? 20.13655 24.07793  -16.55044 1.000 71.45261 ? 224 THR A C   1 
ATOM   1726 O O   . THR A 1 222 ? 19.84328 25.14560  -15.97746 1.000 67.61372 ? 224 THR A O   1 
ATOM   1727 C CB  . THR A 1 222 ? 20.21524 22.98351  -18.88467 1.000 72.07399 ? 224 THR A CB  1 
ATOM   1728 O OG1 . THR A 1 222 ? 20.62860 21.65964  -18.52186 1.000 70.40661 ? 224 THR A OG1 1 
ATOM   1729 C CG2 . THR A 1 222 ? 21.43517 23.85972  -19.18876 1.000 70.58910 ? 224 THR A CG2 1 
ATOM   1730 N N   . THR A 1 223 ? 21.09216 23.27000  -16.11565 1.000 71.01517 ? 225 THR A N   1 
ATOM   1731 C CA  . THR A 1 223 ? 22.07256 23.61413  -15.08540 1.000 73.12957 ? 225 THR A CA  1 
ATOM   1732 C C   . THR A 1 223 ? 23.07705 22.47029  -15.06598 1.000 69.02877 ? 225 THR A C   1 
ATOM   1733 O O   . THR A 1 223 ? 23.01300 21.56126  -15.90368 1.000 66.22402 ? 225 THR A O   1 
ATOM   1734 C CB  . THR A 1 223 ? 21.43608 23.84819  -13.70850 1.000 69.41840 ? 225 THR A CB  1 
ATOM   1735 O OG1 . THR A 1 223 ? 22.46732 24.03774  -12.73121 1.000 66.10522 ? 225 THR A OG1 1 
ATOM   1736 C CG2 . THR A 1 223 ? 20.58301 22.65789  -13.28810 1.000 65.59382 ? 225 THR A CG2 1 
ATOM   1737 N N   . THR A 1 224 ? 24.01173 22.51047  -14.12244 1.000 68.88606 ? 226 THR A N   1 
ATOM   1738 C CA  . THR A 1 224 ? 24.96822 21.42749  -13.97174 1.000 68.55576 ? 226 THR A CA  1 
ATOM   1739 C C   . THR A 1 224 ? 24.80522 20.78930  -12.60252 1.000 65.12149 ? 226 THR A C   1 
ATOM   1740 O O   . THR A 1 224 ? 24.18228 21.35517  -11.69509 1.000 63.33394 ? 226 THR A O   1 
ATOM   1741 C CB  . THR A 1 224 ? 26.42514 21.89277  -14.15702 1.000 66.08734 ? 226 THR A CB  1 
ATOM   1742 O OG1 . THR A 1 224 ? 26.72431 22.98117  -13.26668 1.000 69.00712 ? 226 THR A OG1 1 
ATOM   1743 C CG2 . THR A 1 224 ? 26.67215 22.31092  -15.60348 1.000 68.02953 ? 226 THR A CG2 1 
ATOM   1744 N N   . LEU A 1 225 ? 25.36400 19.58063  -12.49308 1.000 63.47870 ? 227 LEU A N   1 
ATOM   1745 C CA  . LEU A 1 225 ? 25.42267 18.87789  -11.21887 1.000 63.66748 ? 227 LEU A CA  1 
ATOM   1746 C C   . LEU A 1 225 ? 25.99381 19.77519  -10.13589 1.000 64.95911 ? 227 LEU A C   1 
ATOM   1747 O O   . LEU A 1 225 ? 25.41757 19.90427  -9.04801  1.000 63.77365 ? 227 LEU A O   1 
ATOM   1748 C CB  . LEU A 1 225 ? 26.27312 17.61797  -11.36450 1.000 63.63733 ? 227 LEU A CB  1 
ATOM   1749 C CG  . LEU A 1 225 ? 25.57725 16.26815  -11.46759 1.000 58.91077 ? 227 LEU A CG  1 
ATOM   1750 C CD1 . LEU A 1 225 ? 26.62514 15.16671  -11.46565 1.000 61.37940 ? 227 LEU A CD1 1 
ATOM   1751 C CD2 . LEU A 1 225 ? 24.60370 16.09145  -10.32332 1.000 56.78167 ? 227 LEU A CD2 1 
ATOM   1752 N N   . ASN A 1 226 ? 27.12662 20.42151  -10.43782 1.000 68.01542 ? 228 ASN A N   1 
ATOM   1753 C CA  . ASN A 1 226 ? 27.77643 21.31947  -9.48728  1.000 65.05119 ? 228 ASN A CA  1 
ATOM   1754 C C   . ASN A 1 226 ? 26.83738 22.43609  -9.04923  1.000 64.94634 ? 228 ASN A C   1 
ATOM   1755 O O   . ASN A 1 226 ? 26.61482 22.63192  -7.85465  1.000 70.69673 ? 228 ASN A O   1 
ATOM   1756 C CB  . ASN A 1 226 ? 29.04982 21.89314  -10.10815 1.000 61.75442 ? 228 ASN A CB  1 
ATOM   1757 C CG  . ASN A 1 226 ? 30.01794 22.44440  -9.07693  1.000 62.12628 ? 228 ASN A CG  1 
ATOM   1758 O OD1 . ASN A 1 226 ? 30.35714 21.78406  -8.08828  1.000 68.35443 ? 228 ASN A OD1 1 
ATOM   1759 N ND2 . ASN A 1 226 ? 30.48830 23.65878  -9.31905  1.000 60.80474 ? 228 ASN A ND2 1 
ATOM   1760 N N   . ASP A 1 227 ? 26.24112 23.15224  -10.00042 1.000 63.76650 ? 229 ASP A N   1 
ATOM   1761 C CA  . ASP A 1 227 ? 25.46144 24.33271  -9.63224  1.000 72.03546 ? 229 ASP A CA  1 
ATOM   1762 C C   . ASP A 1 227 ? 24.12569 23.97485  -8.98630  1.000 68.03544 ? 229 ASP A C   1 
ATOM   1763 O O   . ASP A 1 227 ? 23.64717 24.70033  -8.10260  1.000 66.41205 ? 229 ASP A O   1 
ATOM   1764 C CB  . ASP A 1 227 ? 25.23917 25.20832  -10.86232 1.000 70.45789 ? 229 ASP A CB  1 
ATOM   1765 C CG  . ASP A 1 227 ? 26.35342 26.20933  -11.05786 1.000 74.98945 ? 229 ASP A CG  1 
ATOM   1766 O OD1 . ASP A 1 227 ? 26.56891 27.05488  -10.15627 1.000 77.83022 ? 229 ASP A OD1 1 
ATOM   1767 O OD2 . ASP A 1 227 ? 27.02468 26.13630  -12.10736 1.000 76.58535 ? 229 ASP A OD2 1 
ATOM   1768 N N   . PHE A 1 228 ? 23.49359 22.89088  -9.43061  1.000 66.27896 ? 230 PHE A N   1 
ATOM   1769 C CA  . PHE A 1 228 ? 22.25238 22.46747  -8.79502  1.000 66.32139 ? 230 PHE A CA  1 
ATOM   1770 C C   . PHE A 1 228 ? 22.51857 21.98391  -7.37052  1.000 63.37115 ? 230 PHE A C   1 
ATOM   1771 O O   . PHE A 1 228 ? 21.81839 22.37651  -6.42894  1.000 59.85788 ? 230 PHE A O   1 
ATOM   1772 C CB  . PHE A 1 228 ? 21.57888 21.38502  -9.65125  1.000 66.21321 ? 230 PHE A CB  1 
ATOM   1773 C CG  . PHE A 1 228 ? 20.58356 20.54145  -8.90839  1.000 62.24759 ? 230 PHE A CG  1 
ATOM   1774 C CD1 . PHE A 1 228 ? 20.99950 19.42660  -8.18179  1.000 58.58566 ? 230 PHE A CD1 1 
ATOM   1775 C CD2 . PHE A 1 228 ? 19.23180 20.86225  -8.93459  1.000 56.97657 ? 230 PHE A CD2 1 
ATOM   1776 C CE1 . PHE A 1 228 ? 20.09484 18.65812  -7.48038  1.000 55.78690 ? 230 PHE A CE1 1 
ATOM   1777 C CE2 . PHE A 1 228 ? 18.31292 20.09216  -8.23823  1.000 61.25252 ? 230 PHE A CE2 1 
ATOM   1778 C CZ  . PHE A 1 228 ? 18.74300 18.98420  -7.51223  1.000 59.79535 ? 230 PHE A CZ  1 
ATOM   1779 N N   . ASN A 1 229 ? 23.54180 21.13680  -7.19649  1.000 61.34087 ? 231 ASN A N   1 
ATOM   1780 C CA  . ASN A 1 229 ? 23.91256 20.63858  -5.86940  1.000 63.02791 ? 231 ASN A CA  1 
ATOM   1781 C C   . ASN A 1 229 ? 24.09059 21.76772  -4.86519  1.000 66.16759 ? 231 ASN A C   1 
ATOM   1782 O O   . ASN A 1 229 ? 23.79157 21.60632  -3.67479  1.000 65.02153 ? 231 ASN A O   1 
ATOM   1783 C CB  . ASN A 1 229 ? 25.20408 19.82245  -5.95579  1.000 57.77496 ? 231 ASN A CB  1 
ATOM   1784 C CG  . ASN A 1 229 ? 24.96445 18.41301  -6.43991  1.000 59.69809 ? 231 ASN A CG  1 
ATOM   1785 O OD1 . ASN A 1 229 ? 24.22977 17.64098  -5.82522  1.000 58.31811 ? 231 ASN A OD1 1 
ATOM   1786 N ND2 . ASN A 1 229 ? 25.55839 18.08006  -7.57389  1.000 59.53762 ? 231 ASN A ND2 1 
ATOM   1787 N N   . LEU A 1 230 ? 24.57849 22.92048  -5.33063  1.000 65.20155 ? 232 LEU A N   1 
ATOM   1788 C CA  . LEU A 1 230 ? 24.87028 24.02405  -4.42467  1.000 68.24709 ? 232 LEU A CA  1 
ATOM   1789 C C   . LEU A 1 230 ? 23.59402 24.74064  -3.98744  1.000 65.64051 ? 232 LEU A C   1 
ATOM   1790 O O   . LEU A 1 230 ? 23.51368 25.25176  -2.86530  1.000 68.65172 ? 232 LEU A O   1 
ATOM   1791 C CB  . LEU A 1 230 ? 25.87076 24.98004  -5.08201  1.000 73.84750 ? 232 LEU A CB  1 
ATOM   1792 C CG  . LEU A 1 230 ? 27.17561 24.32270  -5.58601  1.000 69.73725 ? 232 LEU A CG  1 
ATOM   1793 C CD1 . LEU A 1 230 ? 28.31243 25.30533  -5.79456  1.000 69.36618 ? 232 LEU A CD1 1 
ATOM   1794 C CD2 . LEU A 1 230 ? 27.65510 23.16155  -4.68823  1.000 75.04414 ? 232 LEU A CD2 1 
ATOM   1795 N N   . VAL A 1 231 ? 22.57713 24.77722  -4.84626  1.000 66.80463 ? 233 VAL A N   1 
ATOM   1796 C CA  . VAL A 1 231 ? 21.24629 25.12979  -4.35686  1.000 63.83305 ? 233 VAL A CA  1 
ATOM   1797 C C   . VAL A 1 231 ? 20.69913 24.01872  -3.47333  1.000 63.09233 ? 233 VAL A C   1 
ATOM   1798 O O   . VAL A 1 231 ? 19.97248 24.27885  -2.50602  1.000 64.55641 ? 233 VAL A O   1 
ATOM   1799 C CB  . VAL A 1 231 ? 20.30366 25.41545  -5.54242  1.000 66.69537 ? 233 VAL A CB  1 
ATOM   1800 C CG1 . VAL A 1 231 ? 18.93115 25.90296  -5.06893  1.000 63.69863 ? 233 VAL A CG1 1 
ATOM   1801 C CG2 . VAL A 1 231 ? 20.94378 26.41920  -6.48524  1.000 64.93944 ? 233 VAL A CG2 1 
ATOM   1802 N N   . ALA A 1 232 ? 21.04294 22.76475  -3.78362  1.000 62.20753 ? 234 ALA A N   1 
ATOM   1803 C CA  . ALA A 1 232 ? 20.43072 21.62935  -3.10225  1.000 59.63746 ? 234 ALA A CA  1 
ATOM   1804 C C   . ALA A 1 232 ? 20.82922 21.56567  -1.62919  1.000 62.89388 ? 234 ALA A C   1 
ATOM   1805 O O   . ALA A 1 232 ? 19.99191 21.24770  -0.77537  1.000 64.61412 ? 234 ALA A O   1 
ATOM   1806 C CB  . ALA A 1 232 ? 20.79859 20.33417  -3.82450  1.000 64.04171 ? 234 ALA A CB  1 
ATOM   1807 N N   . MET A 1 233 ? 22.09558 21.86928  -1.30383  1.000 59.86488 ? 235 MET A N   1 
ATOM   1808 C CA  . MET A 1 233 ? 22.51652 21.85068  0.09843   1.000 63.86569 ? 235 MET A CA  1 
ATOM   1809 C C   . MET A 1 233 ? 21.77760 22.90306  0.93255   1.000 61.60701 ? 235 MET A C   1 
ATOM   1810 O O   . MET A 1 233 ? 21.66437 22.74790  2.15764   1.000 61.57097 ? 235 MET A O   1 
ATOM   1811 C CB  . MET A 1 233 ? 24.04271 22.02344  0.21896   1.000 66.99347 ? 235 MET A CB  1 
ATOM   1812 C CG  . MET A 1 233 ? 24.67933 23.04074  -0.73398  1.000 72.77149 ? 235 MET A CG  1 
ATOM   1813 S SD  . MET A 1 233 ? 26.51168 23.04443  -0.71221  1.000 84.59562 ? 235 MET A SD  1 
ATOM   1814 C CE  . MET A 1 233 ? 26.94778 21.50275  -1.52409  1.000 66.53876 ? 235 MET A CE  1 
ATOM   1815 N N   . LYS A 1 234 ? 21.20930 23.93774  0.29197   1.000 60.74224 ? 236 LYS A N   1 
ATOM   1816 C CA  . LYS A 1 234 ? 20.54683 24.98696  1.06290   1.000 59.21114 ? 236 LYS A CA  1 
ATOM   1817 C C   . LYS A 1 234 ? 19.17021 24.54097  1.56215   1.000 61.45533 ? 236 LYS A C   1 
ATOM   1818 O O   . LYS A 1 234 ? 18.72423 24.99265  2.62542   1.000 61.72988 ? 236 LYS A O   1 
ATOM   1819 C CB  . LYS A 1 234 ? 20.41511 26.27209  0.23640   1.000 64.06105 ? 236 LYS A CB  1 
ATOM   1820 C CG  . LYS A 1 234 ? 21.56594 26.63398  -0.74757  1.000 68.40874 ? 236 LYS A CG  1 
ATOM   1821 C CD  . LYS A 1 234 ? 22.99770 26.37680  -0.24060  1.000 65.34370 ? 236 LYS A CD  1 
ATOM   1822 C CE  . LYS A 1 234 ? 23.27846 26.95386  1.14819   1.000 70.04161 ? 236 LYS A CE  1 
ATOM   1823 N NZ  . LYS A 1 234 ? 22.90752 28.39017  1.26818   1.000 75.95166 ? 236 LYS A NZ  1 
ATOM   1824 N N   . TYR A 1 235 ? 18.48302 23.65054  0.83445   1.000 60.68953 ? 237 TYR A N   1 
ATOM   1825 C CA  . TYR A 1 235 ? 17.18200 23.14327  1.26466   1.000 61.84052 ? 237 TYR A CA  1 
ATOM   1826 C C   . TYR A 1 235 ? 17.27758 21.74633  1.88078   1.000 60.78978 ? 237 TYR A C   1 
ATOM   1827 O O   . TYR A 1 235 ? 16.27242 21.02594  1.95136   1.000 62.88255 ? 237 TYR A O   1 
ATOM   1828 C CB  . TYR A 1 235 ? 16.19104 23.16520  0.09835   1.000 60.23897 ? 237 TYR A CB  1 
ATOM   1829 C CG  . TYR A 1 235 ? 15.94661 24.56041  -0.43242  1.000 62.38944 ? 237 TYR A CG  1 
ATOM   1830 C CD1 . TYR A 1 235 ? 16.84142 25.14135  -1.31477  1.000 64.00339 ? 237 TYR A CD1 1 
ATOM   1831 C CD2 . TYR A 1 235 ? 14.83803 25.30739  -0.04088  1.000 61.53700 ? 237 TYR A CD2 1 
ATOM   1832 C CE1 . TYR A 1 235 ? 16.64568 26.42285  -1.79777  1.000 59.24048 ? 237 TYR A CE1 1 
ATOM   1833 C CE2 . TYR A 1 235 ? 14.63412 26.59259  -0.52355  1.000 56.81706 ? 237 TYR A CE2 1 
ATOM   1834 C CZ  . TYR A 1 235 ? 15.53725 27.14180  -1.40136  1.000 61.70386 ? 237 TYR A CZ  1 
ATOM   1835 O OH  . TYR A 1 235 ? 15.31742 28.42338  -1.87457  1.000 71.23274 ? 237 TYR A OH  1 
ATOM   1836 N N   . ASN A 1 236 ? 18.46678 21.37360  2.35326   1.000 61.82240 ? 238 ASN A N   1 
ATOM   1837 C CA  . ASN A 1 236 ? 18.71626 20.08332  2.98397   1.000 59.90906 ? 238 ASN A CA  1 
ATOM   1838 C C   . ASN A 1 236 ? 18.24339 18.94155  2.08821   1.000 54.35194 ? 238 ASN A C   1 
ATOM   1839 O O   . ASN A 1 236 ? 17.57026 18.00599  2.52661   1.000 53.19428 ? 238 ASN A O   1 
ATOM   1840 C CB  . ASN A 1 236 ? 18.09076 20.02015  4.38230   1.000 58.81704 ? 238 ASN A CB  1 
ATOM   1841 C CG  . ASN A 1 236 ? 19.12113 20.30618  5.48779   1.000 67.38406 ? 238 ASN A CG  1 
ATOM   1842 O OD1 . ASN A 1 236 ? 20.03998 19.51342  5.70350   1.000 69.43220 ? 238 ASN A OD1 1 
ATOM   1843 N ND2 . ASN A 1 236 ? 18.99771 21.46212  6.15443   1.000 61.00541 ? 238 ASN A ND2 1 
ATOM   1844 N N   . TYR A 1 237 ? 18.58290 19.05458  0.80530   1.000 47.86532 ? 239 TYR A N   1 
ATOM   1845 C CA  . TYR A 1 237 ? 18.49903 17.95709  -0.14269  1.000 50.40456 ? 239 TYR A CA  1 
ATOM   1846 C C   . TYR A 1 237 ? 19.85942 17.26847  -0.26301  1.000 52.99611 ? 239 TYR A C   1 
ATOM   1847 O O   . TYR A 1 237 ? 20.91805 17.90720  -0.18227  1.000 51.14696 ? 239 TYR A O   1 
ATOM   1848 C CB  . TYR A 1 237 ? 18.02398 18.43093  -1.52626  1.000 49.69127 ? 239 TYR A CB  1 
ATOM   1849 C CG  . TYR A 1 237 ? 16.52111 18.62171  -1.65615  1.000 45.45250 ? 239 TYR A CG  1 
ATOM   1850 C CD1 . TYR A 1 237 ? 15.80655 19.31243  -0.69323  1.000 46.49058 ? 239 TYR A CD1 1 
ATOM   1851 C CD2 . TYR A 1 237 ? 15.81368 18.06552  -2.72382  1.000 42.35690 ? 239 TYR A CD2 1 
ATOM   1852 C CE1 . TYR A 1 237 ? 14.43547 19.47892  -0.79812  1.000 45.71121 ? 239 TYR A CE1 1 
ATOM   1853 C CE2 . TYR A 1 237 ? 14.42250 18.23510  -2.84377  1.000 43.37576 ? 239 TYR A CE2 1 
ATOM   1854 C CZ  . TYR A 1 237 ? 13.74549 18.94057  -1.85904  1.000 44.78084 ? 239 TYR A CZ  1 
ATOM   1855 O OH  . TYR A 1 237 ? 12.37952 19.13342  -1.90714  1.000 52.73090 ? 239 TYR A OH  1 
ATOM   1856 N N   . GLU A 1 238 ? 19.81901 15.94966  -0.44067  1.000 46.34712 ? 240 GLU A N   1 
ATOM   1857 C CA  . GLU A 1 238 ? 21.04268 15.17691  -0.51279  1.000 50.22364 ? 240 GLU A CA  1 
ATOM   1858 C C   . GLU A 1 238 ? 21.80815 15.50977  -1.79477  1.000 48.69016 ? 240 GLU A C   1 
ATOM   1859 O O   . GLU A 1 238 ? 21.20674 15.83101  -2.82267  1.000 45.66613 ? 240 GLU A O   1 
ATOM   1860 C CB  . GLU A 1 238 ? 20.73076 13.67914  -0.46508  1.000 48.53247 ? 240 GLU A CB  1 
ATOM   1861 C CG  . GLU A 1 238 ? 20.27011 13.15916  0.89929   1.000 55.20431 ? 240 GLU A CG  1 
ATOM   1862 C CD  . GLU A 1 238 ? 21.44535 12.95323  1.86096   1.000 61.58385 ? 240 GLU A CD  1 
ATOM   1863 O OE1 . GLU A 1 238 ? 22.43631 12.29676  1.47511   1.000 67.78776 ? 240 GLU A OE1 1 
ATOM   1864 O OE2 . GLU A 1 238 ? 21.39758 13.45326  3.00946   1.000 56.28235 ? 240 GLU A OE2 1 
ATOM   1865 N N   . PRO A 1 239 ? 23.13419 15.40473  -1.76918  1.000 49.40002 ? 241 PRO A N   1 
ATOM   1866 C CA  . PRO A 1 239 ? 23.91314 15.66706  -2.98582  1.000 51.00530 ? 241 PRO A CA  1 
ATOM   1867 C C   . PRO A 1 239 ? 23.56115 14.68149  -4.09578  1.000 55.81639 ? 241 PRO A C   1 
ATOM   1868 O O   . PRO A 1 239 ? 23.36560 13.48892  -3.85598  1.000 54.19946 ? 241 PRO A O   1 
ATOM   1869 C CB  . PRO A 1 239 ? 25.36770 15.48894  -2.52795  1.000 54.37873 ? 241 PRO A CB  1 
ATOM   1870 C CG  . PRO A 1 239 ? 25.32935 15.28478  -1.03936  1.000 52.18159 ? 241 PRO A CG  1 
ATOM   1871 C CD  . PRO A 1 239 ? 23.95753 14.82622  -0.69342  1.000 50.17673 ? 241 PRO A CD  1 
ATOM   1872 N N   . LEU A 1 240 ? 23.50349 15.19554  -5.32257  1.000 52.87453 ? 242 LEU A N   1 
ATOM   1873 C CA  . LEU A 1 240 ? 23.18563 14.40713  -6.50443  1.000 53.19671 ? 242 LEU A CA  1 
ATOM   1874 C C   . LEU A 1 240 ? 24.48691 13.89528  -7.12126  1.000 57.58592 ? 242 LEU A C   1 
ATOM   1875 O O   . LEU A 1 240 ? 25.25349 14.66958  -7.70172  1.000 58.07416 ? 242 LEU A O   1 
ATOM   1876 C CB  . LEU A 1 240 ? 22.39558 15.26405  -7.49195  1.000 54.95938 ? 242 LEU A CB  1 
ATOM   1877 C CG  . LEU A 1 240 ? 21.39022 14.65543  -8.46856  1.000 53.28321 ? 242 LEU A CG  1 
ATOM   1878 C CD1 . LEU A 1 240 ? 20.72118 15.75783  -9.22403  1.000 53.64477 ? 242 LEU A CD1 1 
ATOM   1879 C CD2 . LEU A 1 240 ? 22.07948 13.77575  -9.45610  1.000 55.07864 ? 242 LEU A CD2 1 
ATOM   1880 N N   . THR A 1 241 ? 24.74276 12.59457  -7.00940  1.000 54.04821 ? 243 THR A N   1 
ATOM   1881 C CA  . THR A 1 241 ? 25.96970 12.06960  -7.58780  1.000 57.16199 ? 243 THR A CA  1 
ATOM   1882 C C   . THR A 1 241 ? 25.81151 11.96203  -9.10470  1.000 59.07158 ? 243 THR A C   1 
ATOM   1883 O O   . THR A 1 241 ? 24.76554 12.28978  -9.67736  1.000 57.93281 ? 243 THR A O   1 
ATOM   1884 C CB  . THR A 1 241 ? 26.35381 10.72513  -6.94917  1.000 56.98884 ? 243 THR A CB  1 
ATOM   1885 O OG1 . THR A 1 241 ? 25.30257 9.76794   -7.13404  1.000 56.52120 ? 243 THR A OG1 1 
ATOM   1886 C CG2 . THR A 1 241 ? 26.63296 10.88425  -5.43868  1.000 48.74670 ? 243 THR A CG2 1 
ATOM   1887 N N   . GLN A 1 242 ? 26.88284 11.53875  -9.77589  1.000 62.05295 ? 244 GLN A N   1 
ATOM   1888 C CA  . GLN A 1 242 ? 26.79073 11.26970  -11.20489 1.000 60.74753 ? 244 GLN A CA  1 
ATOM   1889 C C   . GLN A 1 242 ? 26.08789 9.94155   -11.45253 1.000 59.12048 ? 244 GLN A C   1 
ATOM   1890 O O   . GLN A 1 242 ? 25.38453 9.78594   -12.46193 1.000 60.36767 ? 244 GLN A O   1 
ATOM   1891 C CB  . GLN A 1 242 ? 28.18996 11.28448  -11.83118 1.000 60.11587 ? 244 GLN A CB  1 
ATOM   1892 C CG  . GLN A 1 242 ? 28.26396 10.74205  -13.25905 1.000 62.99004 ? 244 GLN A CG  1 
ATOM   1893 C CD  . GLN A 1 242 ? 27.44748 11.56335  -14.25621 1.000 65.33223 ? 244 GLN A CD  1 
ATOM   1894 O OE1 . GLN A 1 242 ? 27.22260 12.76489  -14.06307 1.000 64.57045 ? 244 GLN A OE1 1 
ATOM   1895 N NE2 . GLN A 1 242 ? 26.99829 10.91334  -15.32989 1.000 62.30608 ? 244 GLN A NE2 1 
ATOM   1896 N N   . ASP A 1 243 ? 26.23620 8.99402   -10.52417 1.000 54.19076 ? 245 ASP A N   1 
ATOM   1897 C CA  . ASP A 1 243 ? 25.48406 7.75256   -10.61478 1.000 57.05807 ? 245 ASP A CA  1 
ATOM   1898 C C   . ASP A 1 243 ? 23.98750 7.99756   -10.52690 1.000 55.40248 ? 245 ASP A C   1 
ATOM   1899 O O   . ASP A 1 243 ? 23.20299 7.30291   -11.17460 1.000 54.33915 ? 245 ASP A O   1 
ATOM   1900 C CB  . ASP A 1 243 ? 25.91102 6.79994   -9.51427  1.000 57.63058 ? 245 ASP A CB  1 
ATOM   1901 C CG  . ASP A 1 243 ? 27.40051 6.64916   -9.44159  1.000 64.53560 ? 245 ASP A CG  1 
ATOM   1902 O OD1 . ASP A 1 243 ? 27.85867 5.48656   -9.48659  1.000 62.47151 ? 245 ASP A OD1 1 
ATOM   1903 O OD2 . ASP A 1 243 ? 28.10229 7.69073   -9.32881  1.000 69.86697 ? 245 ASP A OD2 1 
ATOM   1904 N N   . HIS A 1 244 ? 23.56852 8.95316   -9.70095  1.000 53.24198 ? 246 HIS A N   1 
ATOM   1905 C CA  . HIS A 1 244 ? 22.14891 9.29165   -9.64098  1.000 52.92523 ? 246 HIS A CA  1 
ATOM   1906 C C   . HIS A 1 244 ? 21.63621 9.71258   -11.00504 1.000 51.98871 ? 246 HIS A C   1 
ATOM   1907 O O   . HIS A 1 244 ? 20.54088 9.30832   -11.41164 1.000 50.78966 ? 246 HIS A O   1 
ATOM   1908 C CB  . HIS A 1 244 ? 21.90122 10.40211  -8.62183  1.000 53.38749 ? 246 HIS A CB  1 
ATOM   1909 C CG  . HIS A 1 244 ? 22.13473 9.98228   -7.20851  1.000 53.19026 ? 246 HIS A CG  1 
ATOM   1910 N ND1 . HIS A 1 244 ? 22.55646 10.86126  -6.23463  1.000 55.76871 ? 246 HIS A ND1 1 
ATOM   1911 C CD2 . HIS A 1 244 ? 22.00610 8.77848   -6.60295  1.000 52.56696 ? 246 HIS A CD2 1 
ATOM   1912 C CE1 . HIS A 1 244 ? 22.67292 10.21692  -5.08599  1.000 56.27136 ? 246 HIS A CE1 1 
ATOM   1913 N NE2 . HIS A 1 244 ? 22.34872 8.95049   -5.28341  1.000 56.84720 ? 246 HIS A NE2 1 
ATOM   1914 N N   . VAL A 1 245 ? 22.42133 10.52265  -11.72458 1.000 53.76716 ? 247 VAL A N   1 
ATOM   1915 C CA  . VAL A 1 245 ? 22.06885 10.90280  -13.08904 1.000 51.22257 ? 247 VAL A CA  1 
ATOM   1916 C C   . VAL A 1 245 ? 21.95259 9.66603   -13.96108 1.000 50.22788 ? 247 VAL A C   1 
ATOM   1917 O O   . VAL A 1 245 ? 20.98200 9.50390   -14.70771 1.000 50.95560 ? 247 VAL A O   1 
ATOM   1918 C CB  . VAL A 1 245 ? 23.10088 11.89163  -13.65186 1.000 51.72578 ? 247 VAL A CB  1 
ATOM   1919 C CG1 . VAL A 1 245 ? 22.83645 12.14414  -15.11177 1.000 48.43353 ? 247 VAL A CG1 1 
ATOM   1920 C CG2 . VAL A 1 245 ? 23.03825 13.17984  -12.89697 1.000 51.40063 ? 247 VAL A CG2 1 
ATOM   1921 N N   . ASP A 1 246 ? 22.93294 8.75982   -13.85166 1.000 52.70969 ? 248 ASP A N   1 
ATOM   1922 C CA  . ASP A 1 246 ? 22.91837 7.51889   -14.62441 1.000 49.12132 ? 248 ASP A CA  1 
ATOM   1923 C C   . ASP A 1 246 ? 21.73131 6.64398   -14.24446 1.000 51.34983 ? 248 ASP A C   1 
ATOM   1924 O O   . ASP A 1 246 ? 21.13078 5.98264   -15.10184 1.000 49.17432 ? 248 ASP A O   1 
ATOM   1925 C CB  . ASP A 1 246 ? 24.21540 6.74192   -14.40201 1.000 54.86635 ? 248 ASP A CB  1 
ATOM   1926 C CG  . ASP A 1 246 ? 25.43079 7.42985   -15.00253 1.000 60.91663 ? 248 ASP A CG  1 
ATOM   1927 O OD1 . ASP A 1 246 ? 25.25317 8.41683   -15.75490 1.000 59.51029 ? 248 ASP A OD1 1 
ATOM   1928 O OD2 . ASP A 1 246 ? 26.56913 6.97750   -14.71569 1.000 62.21618 ? 248 ASP A OD2 1 
ATOM   1929 N N   . ILE A 1 247 ? 21.39081 6.61184   -12.95687 1.000 50.24343 ? 249 ILE A N   1 
ATOM   1930 C CA  . ILE A 1 247 ? 20.22634 5.85608   -12.50692 1.000 47.52714 ? 249 ILE A CA  1 
ATOM   1931 C C   . ILE A 1 247 ? 18.94241 6.41780   -13.12061 1.000 48.73104 ? 249 ILE A C   1 
ATOM   1932 O O   . ILE A 1 247 ? 17.98697 5.67280   -13.37407 1.000 43.33604 ? 249 ILE A O   1 
ATOM   1933 C CB  . ILE A 1 247 ? 20.20253 5.85397   -10.96300 1.000 48.75992 ? 249 ILE A CB  1 
ATOM   1934 C CG1 . ILE A 1 247 ? 21.23728 4.85881   -10.41112 1.000 49.28930 ? 249 ILE A CG1 1 
ATOM   1935 C CG2 . ILE A 1 247 ? 18.81584 5.55304   -10.41617 1.000 51.09830 ? 249 ILE A CG2 1 
ATOM   1936 C CD1 . ILE A 1 247 ? 21.49107 4.99754   -8.91490  1.000 44.42333 ? 249 ILE A CD1 1 
ATOM   1937 N N   . LEU A 1 248 ? 18.91070 7.72141   -13.41398 1.000 43.97460 ? 250 LEU A N   1 
ATOM   1938 C CA  . LEU A 1 248 ? 17.73553 8.35156   -13.99801 1.000 44.22999 ? 250 LEU A CA  1 
ATOM   1939 C C   . LEU A 1 248 ? 17.67853 8.24185   -15.52369 1.000 46.44540 ? 250 LEU A C   1 
ATOM   1940 O O   . LEU A 1 248 ? 16.69487 8.69161   -16.12272 1.000 48.12485 ? 250 LEU A O   1 
ATOM   1941 C CB  . LEU A 1 248 ? 17.67309 9.82529   -13.57094 1.000 48.44887 ? 250 LEU A CB  1 
ATOM   1942 C CG  . LEU A 1 248 ? 17.34052 10.01487  -12.08612 1.000 42.04196 ? 250 LEU A CG  1 
ATOM   1943 C CD1 . LEU A 1 248 ? 17.62587 11.42080  -11.62515 1.000 40.00534 ? 250 LEU A CD1 1 
ATOM   1944 C CD2 . LEU A 1 248 ? 15.88869 9.67628   -11.84000 1.000 40.86181 ? 250 LEU A CD2 1 
ATOM   1945 N N   . GLY A 1 249 ? 18.68900 7.64735   -16.15862 1.000 44.97570 ? 251 GLY A N   1 
ATOM   1946 C CA  . GLY A 1 249 ? 18.73938 7.46182   -17.59527 1.000 43.27971 ? 251 GLY A CA  1 
ATOM   1947 C C   . GLY A 1 249 ? 17.47715 6.93387   -18.27166 1.000 52.34640 ? 251 GLY A C   1 
ATOM   1948 O O   . GLY A 1 249 ? 16.99588 7.51533   -19.25306 1.000 50.26522 ? 251 GLY A O   1 
ATOM   1949 N N   . PRO A 1 250 ? 16.93120 5.80449   -17.79147 1.000 50.26162 ? 252 PRO A N   1 
ATOM   1950 C CA  . PRO A 1 250 ? 15.67367 5.29714   -18.38709 1.000 48.13489 ? 252 PRO A CA  1 
ATOM   1951 C C   . PRO A 1 250 ? 14.51488 6.28202   -18.31209 1.000 50.56882 ? 252 PRO A C   1 
ATOM   1952 O O   . PRO A 1 250 ? 13.77752 6.44831   -19.29648 1.000 50.03781 ? 252 PRO A O   1 
ATOM   1953 C CB  . PRO A 1 250 ? 15.38601 4.02742   -17.57004 1.000 43.62703 ? 252 PRO A CB  1 
ATOM   1954 C CG  . PRO A 1 250 ? 16.72165 3.59303   -17.06637 1.000 47.41608 ? 252 PRO A CG  1 
ATOM   1955 C CD  . PRO A 1 250 ? 17.50636 4.85870   -16.81792 1.000 48.04084 ? 252 PRO A CD  1 
ATOM   1956 N N   . LEU A 1 251 ? 14.33005 6.93961   -17.16500 1.000 49.45681 ? 253 LEU A N   1 
ATOM   1957 C CA  . LEU A 1 251 ? 13.24934 7.90913   -17.03097 1.000 48.54769 ? 253 LEU A CA  1 
ATOM   1958 C C   . LEU A 1 251 ? 13.44225 9.07703   -17.98885 1.000 50.42431 ? 253 LEU A C   1 
ATOM   1959 O O   . LEU A 1 251 ? 12.50174 9.49592   -18.68058 1.000 45.20368 ? 253 LEU A O   1 
ATOM   1960 C CB  . LEU A 1 251 ? 13.17201 8.40065   -15.59026 1.000 42.95671 ? 253 LEU A CB  1 
ATOM   1961 C CG  . LEU A 1 251 ? 12.55281 7.36349   -14.66829 1.000 42.99771 ? 253 LEU A CG  1 
ATOM   1962 C CD1 . LEU A 1 251 ? 12.37088 7.91269   -13.25604 1.000 37.05973 ? 253 LEU A CD1 1 
ATOM   1963 C CD2 . LEU A 1 251 ? 11.24344 6.89758   -15.26717 1.000 39.95311 ? 253 LEU A CD2 1 
ATOM   1964 N N   . SER A 1 252 ? 14.66252 9.62032   -18.03345 1.000 51.14843 ? 254 SER A N   1 
ATOM   1965 C CA  . SER A 1 252 ? 14.96011 10.73149  -18.93082 1.000 48.86697 ? 254 SER A CA  1 
ATOM   1966 C C   . SER A 1 252 ? 14.73019 10.34129  -20.38589 1.000 54.52295 ? 254 SER A C   1 
ATOM   1967 O O   . SER A 1 252 ? 14.18963 11.12655  -21.17759 1.000 51.61651 ? 254 SER A O   1 
ATOM   1968 C CB  . SER A 1 252 ? 16.39879 11.18394  -18.71247 1.000 49.99190 ? 254 SER A CB  1 
ATOM   1969 O OG  . SER A 1 252 ? 16.94979 11.63344  -19.92378 1.000 53.19458 ? 254 SER A OG  1 
ATOM   1970 N N   . ALA A 1 253 ? 15.10545 9.11253   -20.75132 1.000 57.99202 ? 255 ALA A N   1 
ATOM   1971 C CA  . ALA A 1 253 ? 14.95300 8.68025   -22.13579 1.000 52.75005 ? 255 ALA A CA  1 
ATOM   1972 C C   . ALA A 1 253 ? 13.49182 8.48351   -22.50948 1.000 56.66583 ? 255 ALA A C   1 
ATOM   1973 O O   . ALA A 1 253 ? 13.13405 8.59689   -23.68743 1.000 59.28267 ? 255 ALA A O   1 
ATOM   1974 C CB  . ALA A 1 253 ? 15.74125 7.38960   -22.37220 1.000 53.83071 ? 255 ALA A CB  1 
ATOM   1975 N N   . GLN A 1 254 ? 12.63689 8.17294   -21.53709 1.000 55.05500 ? 256 GLN A N   1 
ATOM   1976 C CA  . GLN A 1 254 ? 11.24788 7.88056   -21.85345 1.000 55.51617 ? 256 GLN A CA  1 
ATOM   1977 C C   . GLN A 1 254 ? 10.41163 9.13176   -22.04649 1.000 57.97794 ? 256 GLN A C   1 
ATOM   1978 O O   . GLN A 1 254 ? 9.34201  9.05185   -22.66293 1.000 57.74769 ? 256 GLN A O   1 
ATOM   1979 C CB  . GLN A 1 254 ? 10.62373 7.03750   -20.75116 1.000 53.85108 ? 256 GLN A CB  1 
ATOM   1980 C CG  . GLN A 1 254 ? 9.55496  6.11941   -21.25228 1.000 61.25671 ? 256 GLN A CG  1 
ATOM   1981 C CD  . GLN A 1 254 ? 8.60624  5.72988   -20.15325 1.000 65.28524 ? 256 GLN A CD  1 
ATOM   1982 O OE1 . GLN A 1 254 ? 9.02691  5.46298   -19.02422 1.000 66.51568 ? 256 GLN A OE1 1 
ATOM   1983 N NE2 . GLN A 1 254 ? 7.31295  5.70104   -20.46610 1.000 70.57536 ? 256 GLN A NE2 1 
ATOM   1984 N N   . THR A 1 255 ? 10.86183 10.26285  -21.50088 1.000 52.98533 ? 257 THR A N   1 
ATOM   1985 C CA  . THR A 1 255 ? 10.15895 11.53492  -21.56116 1.000 55.24963 ? 257 THR A CA  1 
ATOM   1986 C C   . THR A 1 255 ? 10.83763 12.53418  -22.48177 1.000 54.29252 ? 257 THR A C   1 
ATOM   1987 O O   . THR A 1 255 ? 10.26149 13.58825  -22.75861 1.000 50.61652 ? 257 THR A O   1 
ATOM   1988 C CB  . THR A 1 255 ? 10.05796 12.16703  -20.15845 1.000 52.18507 ? 257 THR A CB  1 
ATOM   1989 O OG1 . THR A 1 255 ? 11.37178 12.28274  -19.59840 1.000 49.82241 ? 257 THR A OG1 1 
ATOM   1990 C CG2 . THR A 1 255 ? 9.20085  11.32693  -19.22614 1.000 46.31977 ? 257 THR A CG2 1 
ATOM   1991 N N   . GLY A 1 256 ? 12.04677 12.24155  -22.94593 1.000 58.31026 ? 258 GLY A N   1 
ATOM   1992 C CA  . GLY A 1 256 ? 12.79918 13.22458  -23.68487 1.000 54.67379 ? 258 GLY A CA  1 
ATOM   1993 C C   . GLY A 1 256 ? 13.27513 14.40887  -22.87465 1.000 58.49120 ? 258 GLY A C   1 
ATOM   1994 O O   . GLY A 1 256 ? 13.64347 15.42581  -23.47025 1.000 66.50360 ? 258 GLY A O   1 
ATOM   1995 N N   . ILE A 1 257 ? 13.28938 14.32220  -21.54172 1.000 53.62662 ? 259 ILE A N   1 
ATOM   1996 C CA  . ILE A 1 257 ? 13.77612 15.40057  -20.68719 1.000 48.31337 ? 259 ILE A CA  1 
ATOM   1997 C C   . ILE A 1 257 ? 15.08806 14.96342  -20.06681 1.000 55.79875 ? 259 ILE A C   1 
ATOM   1998 O O   . ILE A 1 257 ? 15.13906 13.95677  -19.34612 1.000 53.37776 ? 259 ILE A O   1 
ATOM   1999 C CB  . ILE A 1 257 ? 12.77444 15.76704  -19.59465 1.000 47.66279 ? 259 ILE A CB  1 
ATOM   2000 C CG1 . ILE A 1 257 ? 11.46435 16.21332  -20.21524 1.000 47.50118 ? 259 ILE A CG1 1 
ATOM   2001 C CG2 . ILE A 1 257 ? 13.36075 16.85457  -18.71017 1.000 53.33185 ? 259 ILE A CG2 1 
ATOM   2002 C CD1 . ILE A 1 257 ? 10.32046 16.10843  -19.26325 1.000 51.99670 ? 259 ILE A CD1 1 
ATOM   2003 N N   . ALA A 1 258 ? 16.14385 15.72578  -20.33304 1.000 59.68497 ? 260 ALA A N   1 
ATOM   2004 C CA  . ALA A 1 258 ? 17.45850 15.37432  -19.81890 1.000 58.19822 ? 260 ALA A CA  1 
ATOM   2005 C C   . ALA A 1 258 ? 17.51510 15.59177  -18.31731 1.000 55.18911 ? 260 ALA A C   1 
ATOM   2006 O O   . ALA A 1 258 ? 16.74617 16.37108  -17.74298 1.000 55.40340 ? 260 ALA A O   1 
ATOM   2007 C CB  . ALA A 1 258 ? 18.55451 16.18599  -20.50867 1.000 60.41331 ? 260 ALA A CB  1 
ATOM   2008 N N   . VAL A 1 259 ? 18.43421 14.87021  -17.68067 1.000 56.18371 ? 261 VAL A N   1 
ATOM   2009 C CA  . VAL A 1 259 ? 18.46611 14.83795  -16.22364 1.000 55.99253 ? 261 VAL A CA  1 
ATOM   2010 C C   . VAL A 1 259 ? 18.71423 16.23473  -15.68119 1.000 56.31336 ? 261 VAL A C   1 
ATOM   2011 O O   . VAL A 1 259 ? 17.98169 16.72040  -14.81079 1.000 60.68434 ? 261 VAL A O   1 
ATOM   2012 C CB  . VAL A 1 259 ? 19.51664 13.82166  -15.73652 1.000 55.32900 ? 261 VAL A CB  1 
ATOM   2013 C CG1 . VAL A 1 259 ? 19.44928 13.64465  -14.23617 1.000 54.35744 ? 261 VAL A CG1 1 
ATOM   2014 C CG2 . VAL A 1 259 ? 19.31291 12.48098  -16.43874 1.000 52.81327 ? 261 VAL A CG2 1 
ATOM   2015 N N   . LEU A 1 260 ? 19.71099 16.92993  -16.23610 1.000 63.13318 ? 262 LEU A N   1 
ATOM   2016 C CA  . LEU A 1 260 ? 20.02163 18.27821  -15.76023 1.000 61.94335 ? 262 LEU A CA  1 
ATOM   2017 C C   . LEU A 1 260 ? 18.91998 19.26929  -16.11406 1.000 59.54654 ? 262 LEU A C   1 
ATOM   2018 O O   . LEU A 1 260 ? 18.77462 20.29623  -15.43914 1.000 60.76769 ? 262 LEU A O   1 
ATOM   2019 C CB  . LEU A 1 260 ? 21.36123 18.75328  -16.32449 1.000 56.65289 ? 262 LEU A CB  1 
ATOM   2020 C CG  . LEU A 1 260 ? 22.58940 17.91016  -15.94216 1.000 60.30369 ? 262 LEU A CG  1 
ATOM   2021 C CD1 . LEU A 1 260 ? 22.50561 17.55552  -14.46162 1.000 58.04319 ? 262 LEU A CD1 1 
ATOM   2022 C CD2 . LEU A 1 260 ? 22.76007 16.65160  -16.80523 1.000 61.45011 ? 262 LEU A CD2 1 
ATOM   2023 N N   . ASP A 1 261 ? 18.13205 18.98612  -17.15883 1.000 57.31585 ? 263 ASP A N   1 
ATOM   2024 C CA  . ASP A 1 261 ? 16.97144 19.82770  -17.44136 1.000 59.21942 ? 263 ASP A CA  1 
ATOM   2025 C C   . ASP A 1 261 ? 15.93863 19.68705  -16.33524 1.000 59.30153 ? 263 ASP A C   1 
ATOM   2026 O O   . ASP A 1 261 ? 15.38910 20.68437  -15.85677 1.000 58.74019 ? 263 ASP A O   1 
ATOM   2027 C CB  . ASP A 1 261 ? 16.35225 19.46893  -18.80113 1.000 61.95361 ? 263 ASP A CB  1 
ATOM   2028 C CG  . ASP A 1 261 ? 17.24372 19.84886  -19.99154 1.000 66.56193 ? 263 ASP A CG  1 
ATOM   2029 O OD1 . ASP A 1 261 ? 18.24454 20.57793  -19.79431 1.000 64.75299 ? 263 ASP A OD1 1 
ATOM   2030 O OD2 . ASP A 1 261 ? 16.93954 19.40647  -21.13196 1.000 64.62148 ? 263 ASP A OD2 1 
ATOM   2031 N N   . MET A 1 262 ? 15.67589 18.45069  -15.90189 1.000 59.77117 ? 264 MET A N   1 
ATOM   2032 C CA  . MET A 1 262 ? 14.74473 18.23890  -14.79804 1.000 56.13818 ? 264 MET A CA  1 
ATOM   2033 C C   . MET A 1 262 ? 15.27519 18.83348  -13.49577 1.000 56.67395 ? 264 MET A C   1 
ATOM   2034 O O   . MET A 1 262 ? 14.49933 19.35626  -12.68481 1.000 55.47549 ? 264 MET A O   1 
ATOM   2035 C CB  . MET A 1 262 ? 14.46183 16.75028  -14.63659 1.000 52.97171 ? 264 MET A CB  1 
ATOM   2036 C CG  . MET A 1 262 ? 13.34101 16.46705  -13.66711 1.000 52.33489 ? 264 MET A CG  1 
ATOM   2037 S SD  . MET A 1 262 ? 11.74379 16.97551  -14.32748 1.000 52.63366 ? 264 MET A SD  1 
ATOM   2038 C CE  . MET A 1 262 ? 11.31189 15.55148  -15.33087 1.000 48.50576 ? 264 MET A CE  1 
ATOM   2039 N N   . CYS A 1 263 ? 16.59251 18.76139  -13.27923 1.000 58.52594 ? 265 CYS A N   1 
ATOM   2040 C CA  . CYS A 1 263 ? 17.19889 19.41031  -12.11736 1.000 59.44737 ? 265 CYS A CA  1 
ATOM   2041 C C   . CYS A 1 263 ? 16.92265 20.90296  -12.11753 1.000 57.23522 ? 265 CYS A C   1 
ATOM   2042 O O   . CYS A 1 263 ? 16.52617 21.47530  -11.09302 1.000 59.24509 ? 265 CYS A O   1 
ATOM   2043 C CB  . CYS A 1 263 ? 18.70428 19.16467  -12.09930 1.000 57.22656 ? 265 CYS A CB  1 
ATOM   2044 S SG  . CYS A 1 263 ? 19.14733 17.45560  -11.87447 1.000 62.22791 ? 265 CYS A SG  1 
ATOM   2045 N N   . ALA A 1 264 ? 17.14340 21.55318  -13.26637 1.000 62.72692 ? 266 ALA A N   1 
ATOM   2046 C CA  . ALA A 1 264 ? 16.86683 22.98337  -13.37949 1.000 61.99261 ? 266 ALA A CA  1 
ATOM   2047 C C   . ALA A 1 264 ? 15.41646 23.27673  -13.04076 1.000 60.37714 ? 266 ALA A C   1 
ATOM   2048 O O   . ALA A 1 264 ? 15.11710 24.27656  -12.37951 1.000 62.86277 ? 266 ALA A O   1 
ATOM   2049 C CB  . ALA A 1 264 ? 17.20111 23.48589  -14.78736 1.000 61.99338 ? 266 ALA A CB  1 
ATOM   2050 N N   . SER A 1 265 ? 14.50161 22.39861  -13.46875 1.000 60.52448 ? 267 SER A N   1 
ATOM   2051 C CA  . SER A 1 265 ? 13.10388 22.52683  -13.06486 1.000 61.16805 ? 267 SER A CA  1 
ATOM   2052 C C   . SER A 1 265 ? 12.93795 22.37745  -11.55242 1.000 58.72579 ? 267 SER A C   1 
ATOM   2053 O O   . SER A 1 265 ? 12.19665 23.14700  -10.93068 1.000 57.84618 ? 267 SER A O   1 
ATOM   2054 C CB  . SER A 1 265 ? 12.24553 21.50732  -13.81616 1.000 56.88129 ? 267 SER A CB  1 
ATOM   2055 O OG  . SER A 1 265 ? 12.26762 21.76012  -15.21545 1.000 61.00370 ? 267 SER A OG  1 
ATOM   2056 N N   . LEU A 1 266 ? 13.62471 21.40382  -10.93654 1.000 54.41188 ? 268 LEU A N   1 
ATOM   2057 C CA  . LEU A 1 266 ? 13.50617 21.23075  -9.48780  1.000 52.71265 ? 268 LEU A CA  1 
ATOM   2058 C C   . LEU A 1 266 ? 14.12505 22.40712  -8.74432  1.000 53.77429 ? 268 LEU A C   1 
ATOM   2059 O O   . LEU A 1 266 ? 13.53019 22.93668  -7.79837  1.000 57.07165 ? 268 LEU A O   1 
ATOM   2060 C CB  . LEU A 1 266 ? 14.14822 19.91223  -9.04205  1.000 49.15832 ? 268 LEU A CB  1 
ATOM   2061 C CG  . LEU A 1 266 ? 14.42191 19.77949  -7.53415  1.000 50.89871 ? 268 LEU A CG  1 
ATOM   2062 C CD1 . LEU A 1 266 ? 13.14845 19.86165  -6.71170  1.000 46.31343 ? 268 LEU A CD1 1 
ATOM   2063 C CD2 . LEU A 1 266 ? 15.17764 18.49748  -7.21183  1.000 51.99963 ? 268 LEU A CD2 1 
ATOM   2064 N N   . LYS A 1 267 ? 15.31671 22.83798  -9.16930  1.000 54.36335 ? 269 LYS A N   1 
ATOM   2065 C CA  . LYS A 1 267 ? 15.95425 24.01639  -8.57895  1.000 59.97464 ? 269 LYS A CA  1 
ATOM   2066 C C   . LYS A 1 267 ? 15.01279 25.22310  -8.51259  1.000 60.51227 ? 269 LYS A C   1 
ATOM   2067 O O   . LYS A 1 267 ? 15.08965 26.02398  -7.57421  1.000 61.60759 ? 269 LYS A O   1 
ATOM   2068 C CB  . LYS A 1 267 ? 17.22281 24.36477  -9.36468  1.000 63.83994 ? 269 LYS A CB  1 
ATOM   2069 C CG  . LYS A 1 267 ? 17.55768 25.86498  -9.41465  1.000 68.15695 ? 269 LYS A CG  1 
ATOM   2070 C CD  . LYS A 1 267 ? 18.71733 26.16478  -10.37881 1.000 66.34239 ? 269 LYS A CD  1 
ATOM   2071 C CE  . LYS A 1 267 ? 20.05517 25.65376  -9.84416  1.000 65.00231 ? 269 LYS A CE  1 
ATOM   2072 N NZ  . LYS A 1 267 ? 20.98671 25.29090  -10.93703 1.000 62.40657 ? 269 LYS A NZ  1 
ATOM   2073 N N   . GLU A 1 268 ? 14.10775 25.37190  -9.48500  1.000 59.89007 ? 270 GLU A N   1 
ATOM   2074 C CA  . GLU A 1 268 ? 13.18635 26.50496  -9.43129  1.000 63.16877 ? 270 GLU A CA  1 
ATOM   2075 C C   . GLU A 1 268 ? 12.11463 26.29440  -8.37614  1.000 65.61314 ? 270 GLU A C   1 
ATOM   2076 O O   . GLU A 1 268 ? 11.75475 27.23260  -7.65152  1.000 65.50388 ? 270 GLU A O   1 
ATOM   2077 C CB  . GLU A 1 268 ? 12.53519 26.76375  -10.79357 1.000 65.60012 ? 270 GLU A CB  1 
ATOM   2078 C CG  . GLU A 1 268 ? 13.50273 26.87084  -11.95267 1.000 65.83010 ? 270 GLU A CG  1 
ATOM   2079 C CD  . GLU A 1 268 ? 14.61547 27.87207  -11.72178 1.000 73.59867 ? 270 GLU A CD  1 
ATOM   2080 O OE1 . GLU A 1 268 ? 14.37822 28.86812  -11.00798 1.000 83.08811 ? 270 GLU A OE1 1 
ATOM   2081 O OE2 . GLU A 1 268 ? 15.73088 27.65781  -12.25510 1.000 79.41088 ? 270 GLU A OE2 1 
ATOM   2082 N N   . LEU A 1 269 ? 11.56670 25.07568  -8.29302  1.000 62.11958 ? 271 LEU A N   1 
ATOM   2083 C CA  . LEU A 1 269 ? 10.50132 24.83676  -7.32481  1.000 62.54670 ? 271 LEU A CA  1 
ATOM   2084 C C   . LEU A 1 269 ? 11.01952 24.95781  -5.90326  1.000 61.90717 ? 271 LEU A C   1 
ATOM   2085 O O   . LEU A 1 269 ? 10.25360 25.28440  -4.99073  1.000 60.50466 ? 271 LEU A O   1 
ATOM   2086 C CB  . LEU A 1 269 ? 9.86766  23.46235  -7.54193  1.000 59.84560 ? 271 LEU A CB  1 
ATOM   2087 C CG  . LEU A 1 269 ? 8.77809  23.41416  -8.60996  1.000 55.16195 ? 271 LEU A CG  1 
ATOM   2088 C CD1 . LEU A 1 269 ? 9.40076  23.00153  -9.89974  1.000 56.77623 ? 271 LEU A CD1 1 
ATOM   2089 C CD2 . LEU A 1 269 ? 7.66661  22.46478  -8.23743  1.000 56.89221 ? 271 LEU A CD2 1 
ATOM   2090 N N   . LEU A 1 270 ? 12.31722 24.71580  -5.69822  1.000 58.09074 ? 272 LEU A N   1 
ATOM   2091 C CA  . LEU A 1 270 ? 12.89561 24.89849  -4.37330  1.000 62.54861 ? 272 LEU A CA  1 
ATOM   2092 C C   . LEU A 1 270 ? 12.86967 26.37130  -3.97162  1.000 63.57594 ? 272 LEU A C   1 
ATOM   2093 O O   . LEU A 1 270 ? 12.44413 26.71944  -2.86079  1.000 59.65964 ? 272 LEU A O   1 
ATOM   2094 C CB  . LEU A 1 270 ? 14.32008 24.33371  -4.34467  1.000 60.18221 ? 272 LEU A CB  1 
ATOM   2095 C CG  . LEU A 1 270 ? 14.46513 22.81320  -4.54104  1.000 56.31693 ? 272 LEU A CG  1 
ATOM   2096 C CD1 . LEU A 1 270 ? 15.91712 22.34774  -4.40890  1.000 53.25983 ? 272 LEU A CD1 1 
ATOM   2097 C CD2 . LEU A 1 270 ? 13.58487 22.04017  -3.57424  1.000 50.70429 ? 272 LEU A CD2 1 
ATOM   2098 N N   . GLN A 1 271 ? 13.28198 27.25554  -4.88168  1.000 62.59787 ? 273 GLN A N   1 
ATOM   2099 C CA  . GLN A 1 271 ? 13.33404 28.68460  -4.59281  1.000 65.95913 ? 273 GLN A CA  1 
ATOM   2100 C C   . GLN A 1 271 ? 11.97258 29.37807  -4.64246  1.000 69.03329 ? 273 GLN A C   1 
ATOM   2101 O O   . GLN A 1 271 ? 11.88610 30.54086  -4.23427  1.000 69.03788 ? 273 GLN A O   1 
ATOM   2102 C CB  . GLN A 1 271 ? 14.29305 29.36630  -5.56760  1.000 63.92174 ? 273 GLN A CB  1 
ATOM   2103 C CG  . GLN A 1 271 ? 15.66922 28.72369  -5.56878  1.000 64.35172 ? 273 GLN A CG  1 
ATOM   2104 C CD  . GLN A 1 271 ? 16.42259 28.91785  -6.87737  1.000 67.72132 ? 273 GLN A CD  1 
ATOM   2105 O OE1 . GLN A 1 271 ? 15.82172 29.16215  -7.92834  1.000 71.53643 ? 273 GLN A OE1 1 
ATOM   2106 N NE2 . GLN A 1 271 ? 17.75143 28.81187  -6.81709  1.000 61.72150 ? 273 GLN A NE2 1 
ATOM   2107 N N   . ASN A 1 272 ? 10.90941 28.69476  -5.09877  1.000 71.90580 ? 274 ASN A N   1 
ATOM   2108 C CA  . ASN A 1 272 ? 9.61390  29.32426  -5.36045  1.000 67.34797 ? 274 ASN A CA  1 
ATOM   2109 C C   . ASN A 1 272 ? 8.39603  28.60137  -4.78303  1.000 73.30297 ? 274 ASN A C   1 
ATOM   2110 O O   . ASN A 1 272 ? 7.30662  29.18656  -4.78802  1.000 77.30934 ? 274 ASN A O   1 
ATOM   2111 C CB  . ASN A 1 272 ? 9.39538  29.47324  -6.87326  1.000 67.34546 ? 274 ASN A CB  1 
ATOM   2112 C CG  . ASN A 1 272 ? 10.27748 30.53918  -7.49320  1.000 73.91766 ? 274 ASN A CG  1 
ATOM   2113 O OD1 . ASN A 1 272 ? 10.25608 31.69727  -7.07161  1.000 80.25231 ? 274 ASN A OD1 1 
ATOM   2114 N ND2 . ASN A 1 272 ? 11.04718 30.15999  -8.51218  1.000 74.11659 ? 274 ASN A ND2 1 
ATOM   2115 N N   . GLY A 1 273 ? 8.52300  27.36234  -4.31227  1.000 66.98457 ? 275 GLY A N   1 
ATOM   2116 C CA  . GLY A 1 273 ? 7.36102  26.62020  -3.86217  1.000 65.46272 ? 275 GLY A CA  1 
ATOM   2117 C C   . GLY A 1 273 ? 6.42162  26.29647  -5.01564  1.000 68.35696 ? 275 GLY A C   1 
ATOM   2118 O O   . GLY A 1 273 ? 6.62584  26.69140  -6.16053  1.000 67.82065 ? 275 GLY A O   1 
ATOM   2119 N N   . MET A 1 274 ? 5.36994  25.54009  -4.69267  1.000 71.21470 ? 276 MET A N   1 
ATOM   2120 C CA  . MET A 1 274 ? 4.36989  25.15005  -5.68031  1.000 71.23082 ? 276 MET A CA  1 
ATOM   2121 C C   . MET A 1 274 ? 3.21091  26.14390  -5.76874  1.000 76.73989 ? 276 MET A C   1 
ATOM   2122 O O   . MET A 1 274 ? 2.36042  26.00497  -6.65786  1.000 73.08610 ? 276 MET A O   1 
ATOM   2123 C CB  . MET A 1 274 ? 3.84659  23.73001  -5.37452  1.000 72.96358 ? 276 MET A CB  1 
ATOM   2124 C CG  . MET A 1 274 ? 4.94597  22.73080  -4.95320  1.000 68.92081 ? 276 MET A CG  1 
ATOM   2125 S SD  . MET A 1 274 ? 4.73563  20.95970  -5.35034  1.000 68.47874 ? 276 MET A SD  1 
ATOM   2126 C CE  . MET A 1 274 ? 2.96717  20.75105  -5.39669  1.000 60.52620 ? 276 MET A CE  1 
ATOM   2127 N N   . ASN A 1 275 ? 3.16262  27.13114  -4.86674  1.000 81.12045 ? 277 ASN A N   1 
ATOM   2128 C CA  . ASN A 1 275 ? 2.25730  28.28111  -4.95536  1.000 75.92927 ? 277 ASN A CA  1 
ATOM   2129 C C   . ASN A 1 275 ? 0.79303  27.87279  -5.12564  1.000 74.04345 ? 277 ASN A C   1 
ATOM   2130 O O   . ASN A 1 275 ? 0.05774  28.42877  -5.94624  1.000 71.86552 ? 277 ASN A O   1 
ATOM   2131 C CB  . ASN A 1 275 ? 2.68606  29.20980  -6.08210  1.000 74.83226 ? 277 ASN A CB  1 
ATOM   2132 C CG  . ASN A 1 275 ? 2.51784  30.65313  -5.71577  1.000 83.14773 ? 277 ASN A CG  1 
ATOM   2133 O OD1 . ASN A 1 275 ? 1.51137  31.03476  -5.11069  1.000 85.06237 ? 277 ASN A OD1 1 
ATOM   2134 N ND2 . ASN A 1 275 ? 3.49845  31.47491  -6.07433  1.000 82.15720 ? 277 ASN A ND2 1 
ATOM   2135 N N   . GLY A 1 276 ? 0.36195  26.90226  -4.32171  1.000 70.49343 ? 278 GLY A N   1 
ATOM   2136 C CA  . GLY A 1 276 ? -1.00235 26.42853  -4.36554  1.000 67.24954 ? 278 GLY A CA  1 
ATOM   2137 C C   . GLY A 1 276 ? -1.25633 25.33319  -5.36716  1.000 66.82461 ? 278 GLY A C   1 
ATOM   2138 O O   . GLY A 1 276 ? -2.31247 24.68768  -5.29888  1.000 65.90141 ? 278 GLY A O   1 
ATOM   2139 N N   . ARG A 1 277 ? -0.31955 25.09667  -6.28361  1.000 73.04726 ? 279 ARG A N   1 
ATOM   2140 C CA  . ARG A 1 277 ? -0.44123 24.02689  -7.26489  1.000 72.38124 ? 279 ARG A CA  1 
ATOM   2141 C C   . ARG A 1 277 ? -0.08456 22.68280  -6.64406  1.000 64.74659 ? 279 ARG A C   1 
ATOM   2142 O O   . ARG A 1 277 ? 0.64979  22.59755  -5.66035  1.000 68.87431 ? 279 ARG A O   1 
ATOM   2143 C CB  . ARG A 1 277 ? 0.46720  24.28027  -8.47542  1.000 70.22802 ? 279 ARG A CB  1 
ATOM   2144 C CG  . ARG A 1 277 ? 0.38731  25.69823  -9.06051  1.000 69.67127 ? 279 ARG A CG  1 
ATOM   2145 C CD  . ARG A 1 277 ? 0.73204  25.69948  -10.54925 1.000 67.45271 ? 279 ARG A CD  1 
ATOM   2146 N NE  . ARG A 1 277 ? 1.76943  26.68221  -10.86630 1.000 71.57298 ? 279 ARG A NE  1 
ATOM   2147 C CZ  . ARG A 1 277 ? 2.31945  26.84208  -12.07318 1.000 75.49752 ? 279 ARG A CZ  1 
ATOM   2148 N NH1 . ARG A 1 277 ? 3.26371  27.76755  -12.26829 1.000 71.43695 ? 279 ARG A NH1 1 
ATOM   2149 N NH2 . ARG A 1 277 ? 1.93386  26.06912  -13.08899 1.000 70.75957 ? 279 ARG A NH2 1 
ATOM   2150 N N   . THR A 1 278 ? -0.62407 21.63184  -7.23143  1.000 65.43569 ? 280 THR A N   1 
ATOM   2151 C CA  . THR A 1 278 ? -0.32253 20.26207  -6.87362  1.000 63.90645 ? 280 THR A CA  1 
ATOM   2152 C C   . THR A 1 278 ? 0.57010  19.64114  -7.93889  1.000 66.38685 ? 280 THR A C   1 
ATOM   2153 O O   . THR A 1 278 ? 0.76507  20.18988  -9.02668  1.000 64.52275 ? 280 THR A O   1 
ATOM   2154 C CB  . THR A 1 278 ? -1.61007 19.44893  -6.72839  1.000 63.64539 ? 280 THR A CB  1 
ATOM   2155 O OG1 . THR A 1 278 ? -2.00460 18.96685  -8.01930  1.000 63.60903 ? 280 THR A OG1 1 
ATOM   2156 C CG2 . THR A 1 278 ? -2.72000 20.31623  -6.14610  1.000 68.81557 ? 280 THR A CG2 1 
ATOM   2157 N N   . ILE A 1 279 ? 1.11193  18.47359  -7.60286  1.000 64.04594 ? 281 ILE A N   1 
ATOM   2158 C CA  . ILE A 1 279 ? 1.80598  17.60552  -8.54351  1.000 58.66839 ? 281 ILE A CA  1 
ATOM   2159 C C   . ILE A 1 279 ? 1.44655  16.18597  -8.15061  1.000 58.38552 ? 281 ILE A C   1 
ATOM   2160 O O   . ILE A 1 279 ? 1.78304  15.75691  -7.04692  1.000 59.92591 ? 281 ILE A O   1 
ATOM   2161 C CB  . ILE A 1 279 ? 3.33014  17.78365  -8.49283  1.000 55.92995 ? 281 ILE A CB  1 
ATOM   2162 C CG1 . ILE A 1 279 ? 3.71961  19.23479  -8.67420  1.000 53.62473 ? 281 ILE A CG1 1 
ATOM   2163 C CG2 . ILE A 1 279 ? 3.98856  16.93347  -9.53895  1.000 54.47198 ? 281 ILE A CG2 1 
ATOM   2164 C CD1 . ILE A 1 279 ? 5.17720  19.42418  -8.98997  1.000 54.32068 ? 281 ILE A CD1 1 
ATOM   2165 N N   . LEU A 1 280 ? 0.77073  15.45676  -9.03212  1.000 58.35024 ? 282 LEU A N   1 
ATOM   2166 C CA  . LEU A 1 280 ? 0.32526  14.10289  -8.71719  1.000 58.45371 ? 282 LEU A CA  1 
ATOM   2167 C C   . LEU A 1 280 ? -0.52031 14.07772  -7.44660  1.000 61.09121 ? 282 LEU A C   1 
ATOM   2168 O O   . LEU A 1 280 ? -0.39657 13.17512  -6.62062  1.000 67.02520 ? 282 LEU A O   1 
ATOM   2169 C CB  . LEU A 1 280 ? 1.51253  13.14818  -8.58853  1.000 57.11362 ? 282 LEU A CB  1 
ATOM   2170 C CG  . LEU A 1 280 ? 2.31578  12.97560  -9.86892  1.000 56.52679 ? 282 LEU A CG  1 
ATOM   2171 C CD1 . LEU A 1 280 ? 3.53763  12.09191  -9.64872  1.000 48.66520 ? 282 LEU A CD1 1 
ATOM   2172 C CD2 . LEU A 1 280 ? 1.42535  12.42842  -10.97398 1.000 51.59367 ? 282 LEU A CD2 1 
ATOM   2173 N N   . GLY A 1 281 ? -1.37245 15.08329  -7.27522  1.000 62.18132 ? 283 GLY A N   1 
ATOM   2174 C CA  . GLY A 1 281 ? -2.29999 15.07555  -6.15769  1.000 61.26922 ? 283 GLY A CA  1 
ATOM   2175 C C   . GLY A 1 281 ? -1.65013 15.38185  -4.83383  1.000 61.41503 ? 283 GLY A C   1 
ATOM   2176 O O   . GLY A 1 281 ? -2.15747 14.97688  -3.78452  1.000 69.60753 ? 283 GLY A O   1 
ATOM   2177 N N   . SER A 1 282 ? -0.53446 16.09284  -4.85617  1.000 63.00321 ? 284 SER A N   1 
ATOM   2178 C CA  . SER A 1 282 ? 0.26509  16.33078  -3.66956  1.000 58.10576 ? 284 SER A CA  1 
ATOM   2179 C C   . SER A 1 282 ? 0.79520  17.74808  -3.71477  1.000 56.82932 ? 284 SER A C   1 
ATOM   2180 O O   . SER A 1 282 ? 1.22531  18.21538  -4.77037  1.000 58.91896 ? 284 SER A O   1 
ATOM   2181 C CB  . SER A 1 282 ? 1.43838  15.35595  -3.57731  1.000 55.27722 ? 284 SER A CB  1 
ATOM   2182 O OG  . SER A 1 282 ? 2.51124  15.97126  -2.88726  1.000 55.18617 ? 284 SER A OG  1 
ATOM   2183 N N   . ALA A 1 283 ? 0.77263  18.42632  -2.57203  1.000 54.89836 ? 285 ALA A N   1 
ATOM   2184 C CA  . ALA A 1 283 ? 1.21583  19.81055  -2.51312  1.000 59.49207 ? 285 ALA A CA  1 
ATOM   2185 C C   . ALA A 1 283 ? 2.64125  19.96065  -2.00642  1.000 57.75298 ? 285 ALA A C   1 
ATOM   2186 O O   . ALA A 1 283 ? 3.13420  21.08904  -1.92300  1.000 60.92268 ? 285 ALA A O   1 
ATOM   2187 C CB  . ALA A 1 283 ? 0.26329  20.63815  -1.65155  1.000 58.76048 ? 285 ALA A CB  1 
ATOM   2188 N N   . LEU A 1 284 ? 3.31014  18.86000  -1.67447  1.000 56.88689 ? 286 LEU A N   1 
ATOM   2189 C CA  . LEU A 1 284 ? 4.73340  18.83920  -1.36234  1.000 57.01562 ? 286 LEU A CA  1 
ATOM   2190 C C   . LEU A 1 284 ? 5.43742  17.86130  -2.29878  1.000 52.99080 ? 286 LEU A C   1 
ATOM   2191 O O   . LEU A 1 284 ? 4.80283  17.09023  -3.01653  1.000 51.37503 ? 286 LEU A O   1 
ATOM   2192 C CB  . LEU A 1 284 ? 4.98973  18.44337  0.10173   1.000 54.04070 ? 286 LEU A CB  1 
ATOM   2193 C CG  . LEU A 1 284 ? 4.52469  19.35310  1.24442   1.000 63.39782 ? 286 LEU A CG  1 
ATOM   2194 C CD1 . LEU A 1 284 ? 4.92350  20.81188  0.98713   1.000 61.26959 ? 286 LEU A CD1 1 
ATOM   2195 C CD2 . LEU A 1 284 ? 3.01346  19.21164  1.51563   1.000 63.31219 ? 286 LEU A CD2 1 
ATOM   2196 N N   . LEU A 1 285 ? 6.76514  17.88311  -2.26691  1.000 46.46990 ? 287 LEU A N   1 
ATOM   2197 C CA  . LEU A 1 285 ? 7.57479  17.04381  -3.13081  1.000 47.45984 ? 287 LEU A CA  1 
ATOM   2198 C C   . LEU A 1 285 ? 7.78897  15.68779  -2.47083  1.000 50.95363 ? 287 LEU A C   1 
ATOM   2199 O O   . LEU A 1 285 ? 8.27998  15.61607  -1.34196  1.000 57.79602 ? 287 LEU A O   1 
ATOM   2200 C CB  . LEU A 1 285 ? 8.90369  17.73261  -3.41487  1.000 48.27236 ? 287 LEU A CB  1 
ATOM   2201 C CG  . LEU A 1 285 ? 8.71719  19.09092  -4.08019  1.000 49.58604 ? 287 LEU A CG  1 
ATOM   2202 C CD1 . LEU A 1 285 ? 10.03355 19.79882  -4.26791  1.000 50.52092 ? 287 LEU A CD1 1 
ATOM   2203 C CD2 . LEU A 1 285 ? 8.02820  18.91950  -5.40811  1.000 53.03221 ? 287 LEU A CD2 1 
ATOM   2204 N N   . GLU A 1 286 ? 7.42133  14.61480  -3.16237  1.000 48.17701 ? 288 GLU A N   1 
ATOM   2205 C CA  . GLU A 1 286 ? 7.56459  13.28345  -2.58662  1.000 46.19386 ? 288 GLU A CA  1 
ATOM   2206 C C   . GLU A 1 286 ? 8.97205  12.75360  -2.82653  1.000 45.56004 ? 288 GLU A C   1 
ATOM   2207 O O   . GLU A 1 286 ? 9.52641  12.89719  -3.91955  1.000 43.44536 ? 288 GLU A O   1 
ATOM   2208 C CB  . GLU A 1 286 ? 6.53765  12.31810  -3.18645  1.000 46.58036 ? 288 GLU A CB  1 
ATOM   2209 C CG  . GLU A 1 286 ? 5.10674  12.85863  -3.21427  1.000 52.24374 ? 288 GLU A CG  1 
ATOM   2210 C CD  . GLU A 1 286 ? 4.31831  12.57958  -1.94788  1.000 59.37043 ? 288 GLU A CD  1 
ATOM   2211 O OE1 . GLU A 1 286 ? 4.94364  12.32198  -0.89250  1.000 63.92984 ? 288 GLU A OE1 1 
ATOM   2212 O OE2 . GLU A 1 286 ? 3.06489  12.60299  -2.02029  1.000 66.35248 ? 288 GLU A OE2 1 
ATOM   2213 N N   . ASP A 1 287 ? 9.54782  12.10917  -1.80793  1.000 44.90135 ? 289 ASP A N   1 
ATOM   2214 C CA  . ASP A 1 287 ? 10.88723 11.56029  -1.97134  1.000 42.36266 ? 289 ASP A CA  1 
ATOM   2215 C C   . ASP A 1 287 ? 10.98617 10.08229  -1.59636  1.000 43.42643 ? 289 ASP A C   1 
ATOM   2216 O O   . ASP A 1 287 ? 12.09107 9.60859   -1.30467  1.000 45.83139 ? 289 ASP A O   1 
ATOM   2217 C CB  . ASP A 1 287 ? 11.90949 12.38229  -1.17668  1.000 39.65114 ? 289 ASP A CB  1 
ATOM   2218 C CG  . ASP A 1 287 ? 11.85971 12.11362  0.30603   1.000 43.43202 ? 289 ASP A CG  1 
ATOM   2219 O OD1 . ASP A 1 287 ? 10.78959 11.67680  0.78757   1.000 48.42429 ? 289 ASP A OD1 1 
ATOM   2220 O OD2 . ASP A 1 287 ? 12.88813 12.36098  0.99214   1.000 45.89609 ? 289 ASP A OD2 1 
ATOM   2221 N N   . GLU A 1 288 ? 9.87892  9.33190   -1.60215  1.000 39.82915 ? 290 GLU A N   1 
ATOM   2222 C CA  . GLU A 1 288 ? 9.93854  7.92183   -1.22227  1.000 42.78654 ? 290 GLU A CA  1 
ATOM   2223 C C   . GLU A 1 288 ? 9.64192  6.98467   -2.38943  1.000 40.33030 ? 290 GLU A C   1 
ATOM   2224 O O   . GLU A 1 288 ? 9.27843  5.83281   -2.15950  1.000 40.40048 ? 290 GLU A O   1 
ATOM   2225 C CB  . GLU A 1 288 ? 9.00089  7.62399   -0.04613  1.000 39.59122 ? 290 GLU A CB  1 
ATOM   2226 C CG  . GLU A 1 288 ? 9.36405  8.39017   1.23353   1.000 44.56087 ? 290 GLU A CG  1 
ATOM   2227 C CD  . GLU A 1 288 ? 9.06536  7.64021   2.54721   1.000 45.51387 ? 290 GLU A CD  1 
ATOM   2228 O OE1 . GLU A 1 288 ? 8.21197  6.70853   2.57330   1.000 50.45662 ? 290 GLU A OE1 1 
ATOM   2229 O OE2 . GLU A 1 288 ? 9.68349  8.02106   3.56191   1.000 41.08583 ? 290 GLU A OE2 1 
ATOM   2230 N N   . PHE A 1 289 ? 9.77751  7.46045   -3.63270  1.000 39.03703 ? 291 PHE A N   1 
ATOM   2231 C CA  . PHE A 1 289 ? 9.79694  6.61022   -4.82388  1.000 41.43294 ? 291 PHE A CA  1 
ATOM   2232 C C   . PHE A 1 289 ? 11.18567 6.66371   -5.44573  1.000 41.78350 ? 291 PHE A C   1 
ATOM   2233 O O   . PHE A 1 289 ? 11.64075 7.73898   -5.86543  1.000 39.22530 ? 291 PHE A O   1 
ATOM   2234 C CB  . PHE A 1 289 ? 8.77959  7.04853   -5.87530  1.000 39.66238 ? 291 PHE A CB  1 
ATOM   2235 C CG  . PHE A 1 289 ? 7.36066  6.94278   -5.43896  1.000 44.01034 ? 291 PHE A CG  1 
ATOM   2236 C CD1 . PHE A 1 289 ? 6.79122  7.93767   -4.66035  1.000 41.82948 ? 291 PHE A CD1 1 
ATOM   2237 C CD2 . PHE A 1 289 ? 6.57686  5.85871   -5.84052  1.000 47.29797 ? 291 PHE A CD2 1 
ATOM   2238 C CE1 . PHE A 1 289 ? 5.45739  7.85135   -4.27352  1.000 49.94088 ? 291 PHE A CE1 1 
ATOM   2239 C CE2 . PHE A 1 289 ? 5.25920  5.75571   -5.46349  1.000 43.44001 ? 291 PHE A CE2 1 
ATOM   2240 C CZ  . PHE A 1 289 ? 4.68810  6.74877   -4.68325  1.000 50.74780 ? 291 PHE A CZ  1 
ATOM   2241 N N   . THR A 1 290 ? 11.83899 5.50829   -5.52884  1.000 38.46057 ? 292 THR A N   1 
ATOM   2242 C CA  . THR A 1 290 ? 13.08205 5.38631   -6.26422  1.000 40.12731 ? 292 THR A CA  1 
ATOM   2243 C C   . THR A 1 290 ? 12.80121 5.48918   -7.75912  1.000 39.14096 ? 292 THR A C   1 
ATOM   2244 O O   . THR A 1 290 ? 11.64583 5.43454   -8.19270  1.000 34.41640 ? 292 THR A O   1 
ATOM   2245 C CB  . THR A 1 290 ? 13.75910 4.05595   -5.95152  1.000 38.89219 ? 292 THR A CB  1 
ATOM   2246 O OG1 . THR A 1 290 ? 12.95208 3.00011   -6.47426  1.000 41.61498 ? 292 THR A OG1 1 
ATOM   2247 C CG2 . THR A 1 290 ? 13.94052 3.88387   -4.45285  1.000 37.53988 ? 292 THR A CG2 1 
ATOM   2248 N N   . PRO A 1 291 ? 13.84425 5.65711   -8.57637  1.000 39.28132 ? 293 PRO A N   1 
ATOM   2249 C CA  . PRO A 1 291 ? 13.63988 5.55718   -10.02669 1.000 37.96321 ? 293 PRO A CA  1 
ATOM   2250 C C   . PRO A 1 291 ? 13.14994 4.18734   -10.46003 1.000 44.57804 ? 293 PRO A C   1 
ATOM   2251 O O   . PRO A 1 291 ? 12.44276 4.09417   -11.47233 1.000 47.01415 ? 293 PRO A O   1 
ATOM   2252 C CB  . PRO A 1 291 ? 15.02677 5.87723   -10.59011 1.000 40.95454 ? 293 PRO A CB  1 
ATOM   2253 C CG  . PRO A 1 291 ? 15.65217 6.73534   -9.53254  1.000 43.14023 ? 293 PRO A CG  1 
ATOM   2254 C CD  . PRO A 1 291 ? 15.20301 6.12333   -8.24921  1.000 38.35924 ? 293 PRO A CD  1 
ATOM   2255 N N   . PHE A 1 292 ? 13.47840 3.12372   -9.71237  1.000 44.81355 ? 294 PHE A N   1 
ATOM   2256 C CA  . PHE A 1 292 ? 12.95883 1.79647   -10.03788 1.000 46.48949 ? 294 PHE A CA  1 
ATOM   2257 C C   . PHE A 1 292 ? 11.47987 1.67711   -9.69288  1.000 49.98645 ? 294 PHE A C   1 
ATOM   2258 O O   . PHE A 1 292 ? 10.69770 1.11909   -10.47285 1.000 48.60058 ? 294 PHE A O   1 
ATOM   2259 C CB  . PHE A 1 292 ? 13.75669 0.71397   -9.31234  1.000 53.83024 ? 294 PHE A CB  1 
ATOM   2260 C CG  . PHE A 1 292 ? 13.38326 -0.69093  -9.72259  1.000 56.35602 ? 294 PHE A CG  1 
ATOM   2261 C CD1 . PHE A 1 292 ? 12.34083 -1.36350  -9.08952  1.000 57.22535 ? 294 PHE A CD1 1 
ATOM   2262 C CD2 . PHE A 1 292 ? 14.07410 -1.33741  -10.73775 1.000 58.77030 ? 294 PHE A CD2 1 
ATOM   2263 C CE1 . PHE A 1 292 ? 11.99108 -2.65278  -9.46277  1.000 61.09939 ? 294 PHE A CE1 1 
ATOM   2264 C CE2 . PHE A 1 292 ? 13.73360 -2.63167  -11.11986 1.000 64.79618 ? 294 PHE A CE2 1 
ATOM   2265 C CZ  . PHE A 1 292 ? 12.68865 -3.29023  -10.48156 1.000 65.16048 ? 294 PHE A CZ  1 
ATOM   2266 N N   . ASP A 1 293 ? 11.07911 2.16366   -8.51212  1.000 45.47416 ? 295 ASP A N   1 
ATOM   2267 C CA  . ASP A 1 293 ? 9.65556  2.18245   -8.18831  1.000 43.61955 ? 295 ASP A CA  1 
ATOM   2268 C C   . ASP A 1 293 ? 8.85578  2.89920   -9.27147  1.000 47.13961 ? 295 ASP A C   1 
ATOM   2269 O O   . ASP A 1 293 ? 7.75467  2.46539   -9.62821  1.000 51.12105 ? 295 ASP A O   1 
ATOM   2270 C CB  . ASP A 1 293 ? 9.42028  2.84747   -6.83373  1.000 43.03372 ? 295 ASP A CB  1 
ATOM   2271 C CG  . ASP A 1 293 ? 10.13366 2.13330   -5.68679  1.000 47.86836 ? 295 ASP A CG  1 
ATOM   2272 O OD1 . ASP A 1 293 ? 10.48995 0.94967   -5.85396  1.000 56.84649 ? 295 ASP A OD1 1 
ATOM   2273 O OD2 . ASP A 1 293 ? 10.32716 2.74743   -4.60860  1.000 45.93190 ? 295 ASP A OD2 1 
ATOM   2274 N N   . VAL A 1 294 ? 9.39855  3.99599   -9.81655  1.000 47.10977 ? 296 VAL A N   1 
ATOM   2275 C CA  . VAL A 1 294 ? 8.67875  4.75339   -10.83900 1.000 43.48657 ? 296 VAL A CA  1 
ATOM   2276 C C   . VAL A 1 294 ? 8.67692  4.00763   -12.17440 1.000 49.39831 ? 296 VAL A C   1 
ATOM   2277 O O   . VAL A 1 294 ? 7.65911  3.97304   -12.87578 1.000 54.56885 ? 296 VAL A O   1 
ATOM   2278 C CB  . VAL A 1 294 ? 9.27131  6.16740   -10.98495 1.000 42.19165 ? 296 VAL A CB  1 
ATOM   2279 C CG1 . VAL A 1 294 ? 8.65117  6.87654   -12.17177 1.000 37.72951 ? 296 VAL A CG1 1 
ATOM   2280 C CG2 . VAL A 1 294 ? 9.04287  6.97574   -9.72914  1.000 42.00307 ? 296 VAL A CG2 1 
ATOM   2281 N N   . VAL A 1 295 ? 9.81503  3.42915   -12.56680 1.000 47.39599 ? 297 VAL A N   1 
ATOM   2282 C CA  . VAL A 1 295 ? 9.85128  2.62354   -13.78548 1.000 49.18604 ? 297 VAL A CA  1 
ATOM   2283 C C   . VAL A 1 295 ? 8.94725  1.40330   -13.63584 1.000 53.55770 ? 297 VAL A C   1 
ATOM   2284 O O   . VAL A 1 295 ? 8.19136  1.05454   -14.54870 1.000 54.82527 ? 297 VAL A O   1 
ATOM   2285 C CB  . VAL A 1 295 ? 11.30131 2.21580   -14.11555 1.000 46.66938 ? 297 VAL A CB  1 
ATOM   2286 C CG1 . VAL A 1 295 ? 11.32317 0.90707   -14.88955 1.000 45.90471 ? 297 VAL A CG1 1 
ATOM   2287 C CG2 . VAL A 1 295 ? 12.00039 3.30006   -14.90405 1.000 45.71450 ? 297 VAL A CG2 1 
ATOM   2288 N N   . ARG A 1 296 ? 8.99613  0.75309   -12.47094 1.000 50.66069 ? 298 ARG A N   1 
ATOM   2289 C CA  . ARG A 1 296 ? 8.19414  -0.44404  -12.23685 1.000 55.64218 ? 298 ARG A CA  1 
ATOM   2290 C C   . ARG A 1 296 ? 6.70536  -0.13116  -12.26979 1.000 59.53937 ? 298 ARG A C   1 
ATOM   2291 O O   . ARG A 1 296 ? 5.92283  -0.87462  -12.86797 1.000 62.49496 ? 298 ARG A O   1 
ATOM   2292 C CB  . ARG A 1 296 ? 8.58433  -1.06827  -10.89811 1.000 55.89868 ? 298 ARG A CB  1 
ATOM   2293 C CG  . ARG A 1 296 ? 7.71554  -2.19870  -10.41165 1.000 61.32432 ? 298 ARG A CG  1 
ATOM   2294 C CD  . ARG A 1 296 ? 8.27648  -2.75003  -9.08878  1.000 58.29470 ? 298 ARG A CD  1 
ATOM   2295 N NE  . ARG A 1 296 ? 7.23335  -2.97521  -8.08417  1.000 59.46626 ? 298 ARG A NE  1 
ATOM   2296 C CZ  . ARG A 1 296 ? 7.20414  -2.41889  -6.86914  1.000 61.50367 ? 298 ARG A CZ  1 
ATOM   2297 N NH1 . ARG A 1 296 ? 6.19623  -2.70900  -6.04013  1.000 55.70634 ? 298 ARG A NH1 1 
ATOM   2298 N NH2 . ARG A 1 296 ? 8.17916  -1.58866  -6.46773  1.000 54.53396 ? 298 ARG A NH2 1 
ATOM   2299 N N   . GLN A 1 297 ? 6.29035  0.96568   -11.63306 1.000 58.23925 ? 299 GLN A N   1 
ATOM   2300 C CA  . GLN A 1 297 ? 4.87847  1.32084   -11.66038 1.000 54.60572 ? 299 GLN A CA  1 
ATOM   2301 C C   . GLN A 1 297 ? 4.43526  1.74793   -13.05247 1.000 59.37528 ? 299 GLN A C   1 
ATOM   2302 O O   . GLN A 1 297 ? 3.26590  1.57263   -13.40478 1.000 66.10968 ? 299 GLN A O   1 
ATOM   2303 C CB  . GLN A 1 297 ? 4.58244  2.42466   -10.64343 1.000 55.44734 ? 299 GLN A CB  1 
ATOM   2304 C CG  . GLN A 1 297 ? 3.08318  2.68465   -10.44184 1.000 51.42305 ? 299 GLN A CG  1 
ATOM   2305 C CD  . GLN A 1 297 ? 2.74901  3.33440   -9.11009  1.000 49.68989 ? 299 GLN A CD  1 
ATOM   2306 O OE1 . GLN A 1 297 ? 1.68811  3.94026   -8.95642  1.000 49.99088 ? 299 GLN A OE1 1 
ATOM   2307 N NE2 . GLN A 1 297 ? 3.65236  3.21434   -8.14148  1.000 49.05618 ? 299 GLN A NE2 1 
ATOM   2308 N N   . CYS A 1 298 ? 5.34171  2.28589   -13.86342 1.000 63.01775 ? 300 CYS A N   1 
ATOM   2309 C CA  . CYS A 1 298 ? 5.01625  2.73602   -15.21585 1.000 62.78996 ? 300 CYS A CA  1 
ATOM   2310 C C   . CYS A 1 298 ? 5.39333  1.72038   -16.29989 1.000 61.52767 ? 300 CYS A C   1 
ATOM   2311 O O   . CYS A 1 298 ? 5.23079  2.01001   -17.49049 1.000 62.88105 ? 300 CYS A O   1 
ATOM   2312 C CB  . CYS A 1 298 ? 5.68708  4.09718   -15.47327 1.000 58.60000 ? 300 CYS A CB  1 
ATOM   2313 S SG  . CYS A 1 298 ? 5.03995  5.43697   -14.37036 1.000 64.25654 ? 300 CYS A SG  1 
ATOM   2314 N N   . SER A 1 299 ? 5.88504  0.53704   -15.90250 1.000 66.11202 ? 301 SER A N   1 
ATOM   2315 C CA  . SER A 1 299 ? 6.16922  -0.60352  -16.77074 1.000 62.60276 ? 301 SER A CA  1 
ATOM   2316 C C   . SER A 1 299 ? 5.43160  -1.88008  -16.37398 1.000 70.96939 ? 301 SER A C   1 
ATOM   2317 O O   . SER A 1 299 ? 5.51287  -2.87402  -17.11203 1.000 78.29974 ? 301 SER A O   1 
ATOM   2318 C CB  . SER A 1 299 ? 7.68216  -0.89913  -16.77897 1.000 68.94913 ? 301 SER A CB  1 
ATOM   2319 O OG  . SER A 1 299 ? 7.95790  -2.28690  -16.94582 1.000 71.11648 ? 301 SER A OG  1 
ATOM   2320 N N   . GLY A 1 300 ? 4.74655  -1.89313  -15.22530 1.000 69.24324 ? 302 GLY A N   1 
ATOM   2321 C CA  . GLY A 1 300 ? 3.98845  -3.03638  -14.74686 1.000 61.94224 ? 302 GLY A CA  1 
ATOM   2322 C C   . GLY A 1 300 ? 4.81803  -4.28884  -14.58161 1.000 58.21433 ? 302 GLY A C   1 
ATOM   2323 O O   . GLY A 1 300 ? 4.51621  -5.31388  -15.19792 1.000 52.83627 ? 302 GLY A O   1 
ATOM   2324 N N   . VAL A 1 301 ? 5.87056  -4.21240  -13.76890 1.000 58.10025 ? 303 VAL A N   1 
ATOM   2325 C CA  . VAL A 1 301 ? 6.76578  -5.34981  -13.55193 1.000 64.59977 ? 303 VAL A CA  1 
ATOM   2326 C C   . VAL A 1 301 ? 6.03673  -6.42887  -12.76432 1.000 59.20596 ? 303 VAL A C   1 
ATOM   2327 O O   . VAL A 1 301 ? 5.45697  -6.13784  -11.72007 1.000 54.02225 ? 303 VAL A O   1 
ATOM   2328 C CB  . VAL A 1 301 ? 8.07207  -4.92862  -12.81715 1.000 63.49222 ? 303 VAL A CB  1 
ATOM   2329 C CG1 . VAL A 1 301 ? 8.92741  -6.15852  -12.49162 1.000 55.29665 ? 303 VAL A CG1 1 
ATOM   2330 C CG2 . VAL A 1 301 ? 8.86256  -3.92832  -13.64376 1.000 62.48879 ? 303 VAL A CG2 1 
HETATM 2331 C C02 . X77 B 2 .   ? 6.80022  -2.45893  21.67924  1.000 49.47290 ? 401 X77 A C02 1 
HETATM 2332 C C04 . X77 B 2 .   ? 7.41125  0.02998   21.39732  1.000 44.20731 ? 401 X77 A C04 1 
HETATM 2333 C C05 . X77 B 2 .   ? 8.59479  0.95151   21.52479  1.000 44.87105 ? 401 X77 A C05 1 
HETATM 2334 C C07 . X77 B 2 .   ? 9.69614  2.82662   22.74817  1.000 49.04205 ? 401 X77 A C07 1 
HETATM 2335 C C08 . X77 B 2 .   ? 9.03216  4.19158   22.89695  1.000 48.11107 ? 401 X77 A C08 1 
HETATM 2336 C C09 . X77 B 2 .   ? 9.79870  5.18324   23.75673  1.000 49.60748 ? 401 X77 A C09 1 
HETATM 2337 C C10 . X77 B 2 .   ? 11.22903 4.72426   23.99194  1.000 48.76381 ? 401 X77 A C10 1 
HETATM 2338 C C11 . X77 B 2 .   ? 11.21074 3.39764   24.73746  1.000 51.36113 ? 401 X77 A C11 1 
HETATM 2339 C C12 . X77 B 2 .   ? 10.50556 2.30729   23.93931  1.000 51.17032 ? 401 X77 A C12 1 
HETATM 2340 C C14 . X77 B 2 .   ? 6.86984  0.29154   19.99441  1.000 50.37615 ? 401 X77 A C14 1 
HETATM 2341 C C15 . X77 B 2 .   ? 5.74991  1.27659   19.86843  1.000 45.00187 ? 401 X77 A C15 1 
HETATM 2342 C C16 . X77 B 2 .   ? 5.18370  1.58050   18.52620  1.000 48.07125 ? 401 X77 A C16 1 
HETATM 2343 C C17 . X77 B 2 .   ? 5.78075  0.89631   17.30155  1.000 48.07883 ? 401 X77 A C17 1 
HETATM 2344 C C19 . X77 B 2 .   ? 7.47001  -0.39171  18.77440  1.000 44.13955 ? 401 X77 A C19 1 
HETATM 2345 C C20 . X77 B 2 .   ? 9.08923  -1.52872  22.37324  1.000 50.66411 ? 401 X77 A C20 1 
HETATM 2346 C C21 . X77 B 2 .   ? 9.24415  -1.21351  23.84880  1.000 47.65570 ? 401 X77 A C21 1 
HETATM 2347 C C22 . X77 B 2 .   ? 10.61197 -1.36995  24.50005  1.000 46.58810 ? 401 X77 A C22 1 
HETATM 2348 C C23 . X77 B 2 .   ? 11.79632 -1.84157  23.66641  1.000 42.49656 ? 401 X77 A C23 1 
HETATM 2349 C C24 . X77 B 2 .   ? 13.12482 -1.97351  24.40145  1.000 44.53609 ? 401 X77 A C24 1 
HETATM 2350 C C25 . X77 B 2 .   ? 13.02003 -3.05955  25.45611  1.000 50.23890 ? 401 X77 A C25 1 
HETATM 2351 C C26 . X77 B 2 .   ? 13.34156 -0.64331  25.06358  1.000 45.20235 ? 401 X77 A C26 1 
HETATM 2352 C C27 . X77 B 2 .   ? 14.25863 -2.31772  23.41307  1.000 47.81555 ? 401 X77 A C27 1 
HETATM 2353 C C28 . X77 B 2 .   ? 11.65631 -2.15458  22.19084  1.000 47.25467 ? 401 X77 A C28 1 
HETATM 2354 C C29 . X77 B 2 .   ? 10.27939 -1.99476  21.52177  1.000 46.82343 ? 401 X77 A C29 1 
HETATM 2355 C C30 . X77 B 2 .   ? 7.09891  -3.90220  22.12219  1.000 44.75721 ? 401 X77 A C30 1 
HETATM 2356 C C31 . X77 B 2 .   ? 6.25538  -4.97014  21.94259  1.000 49.54647 ? 401 X77 A C31 1 
HETATM 2357 C C33 . X77 B 2 .   ? 8.02857  -5.66137  22.96482  1.000 45.54941 ? 401 X77 A C33 1 
HETATM 2358 N N03 . X77 B 2 .   ? 7.76386  -1.34257  21.78123  1.000 44.55748 ? 401 X77 A N03 1 
HETATM 2359 N N06 . X77 B 2 .   ? 8.57730  1.91093   22.61184  1.000 46.78392 ? 401 X77 A N06 1 
HETATM 2360 N N18 . X77 B 2 .   ? 6.90806  -0.06066  17.45115  1.000 43.62030 ? 401 X77 A N18 1 
HETATM 2361 N N32 . X77 B 2 .   ? 6.83912  -6.03924  22.45429  1.000 53.89987 ? 401 X77 A N32 1 
HETATM 2362 N N34 . X77 B 2 .   ? 8.16288  -4.33352  22.74763  1.000 44.42142 ? 401 X77 A N34 1 
HETATM 2363 O O01 . X77 B 2 .   ? 5.74796  -2.23728  21.20858  1.000 52.10125 ? 401 X77 A O01 1 
HETATM 2364 O O13 . X77 B 2 .   ? 9.48898  0.92836   20.76278  1.000 47.76713 ? 401 X77 A O13 1 
HETATM 2365 O O   . HOH C 3 .   ? 17.54858 11.41715  6.70394   1.000 51.40108 ? 501 HOH A O   1 
HETATM 2366 O O   . HOH C 3 .   ? 18.39758 18.55486  -22.78117 1.000 55.61879 ? 502 HOH A O   1 
HETATM 2367 O O   . HOH C 3 .   ? 17.34434 29.25272  -2.82077  1.000 60.82522 ? 503 HOH A O   1 
HETATM 2368 O O   . HOH C 3 .   ? -0.87393 -18.05217 21.89489  1.000 58.70369 ? 504 HOH A O   1 
HETATM 2369 O O   . HOH C 3 .   ? 23.70052 1.50677   16.12501  1.000 42.21455 ? 505 HOH A O   1 
HETATM 2370 O O   . HOH C 3 .   ? 10.28509 6.14034   5.71077   1.000 34.49126 ? 506 HOH A O   1 
HETATM 2371 O O   . HOH C 3 .   ? 24.23137 -6.99936  26.02152  1.000 43.32286 ? 507 HOH A O   1 
HETATM 2372 O O   . HOH C 3 .   ? 10.07493 10.00110  -4.63580  1.000 39.35768 ? 508 HOH A O   1 
HETATM 2373 O O   . HOH C 3 .   ? 16.00032 -5.95916  19.90908  1.000 36.03419 ? 509 HOH A O   1 
HETATM 2374 O O   . HOH C 3 .   ? 22.62024 -8.53676  5.02823   1.000 52.27680 ? 510 HOH A O   1 
HETATM 2375 O O   . HOH C 3 .   ? 24.68427 0.69695   6.80006   1.000 43.65234 ? 511 HOH A O   1 
HETATM 2376 O O   . HOH C 3 .   ? 4.21093  -12.38632 -2.50773  1.000 42.23908 ? 512 HOH A O   1 
HETATM 2377 O O   . HOH C 3 .   ? 21.29157 -19.69963 27.35446  1.000 52.50895 ? 513 HOH A O   1 
HETATM 2378 O O   . HOH C 3 .   ? 13.51201 9.55542   19.79674  1.000 63.21482 ? 514 HOH A O   1 
HETATM 2379 O O   . HOH C 3 .   ? 14.65130 -0.24515  -3.56986  1.000 47.10148 ? 515 HOH A O   1 
HETATM 2380 O O   . HOH C 3 .   ? -1.244   -19.776   26.609    1.000 59.69118 ? 516 HOH A O   1 
# 
