data_8YKO
# 
_entry.id   8YKO 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YKO         pdb_00008yko 10.2210/pdb8yko/pdb 
WWPDB D_1300043866 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YKO 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rmsl_2040@163.com 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9511-4219 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, W.W.'  1 ? 
'Zhang, J.' 2 ? 
'Li, J.'    3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            276 
_citation.language                  ? 
_citation.page_first                133706 
_citation.page_last                 133706 
_citation.title                     
'Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.133706 
_citation.pdbx_database_id_PubMed   38981557 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jiang, H.' 1 ? 
primary 'Li, W.'    2 ? 
primary 'Zhou, X.'  3 ? 
primary 'Zhang, J.' 4 ? 
primary 'Li, J.'    5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                                    
33102.785 2   3.4.22.69 M132H ? ? 
2 non-polymer syn 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' 
459.583   2   ?         ?     ? ? 
3 water       nat water                                                                                                        
18.015    171 ?         ?     ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
;
_entity_poly.pdbx_seq_one_letter_code_can   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' X77 
3 water                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PHE n 
1 2   ARG n 
1 3   LYS n 
1 4   MET n 
1 5   ALA n 
1 6   PHE n 
1 7   PRO n 
1 8   SER n 
1 9   GLY n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  GLY n 
1 14  CYS n 
1 15  MET n 
1 16  VAL n 
1 17  GLN n 
1 18  VAL n 
1 19  THR n 
1 20  CYS n 
1 21  GLY n 
1 22  THR n 
1 23  THR n 
1 24  THR n 
1 25  LEU n 
1 26  ASN n 
1 27  GLY n 
1 28  LEU n 
1 29  TRP n 
1 30  LEU n 
1 31  ASP n 
1 32  ASP n 
1 33  VAL n 
1 34  VAL n 
1 35  TYR n 
1 36  CYS n 
1 37  PRO n 
1 38  ARG n 
1 39  HIS n 
1 40  VAL n 
1 41  ILE n 
1 42  CYS n 
1 43  THR n 
1 44  SER n 
1 45  GLU n 
1 46  ASP n 
1 47  MET n 
1 48  LEU n 
1 49  ASN n 
1 50  PRO n 
1 51  ASN n 
1 52  TYR n 
1 53  GLU n 
1 54  ASP n 
1 55  LEU n 
1 56  LEU n 
1 57  ILE n 
1 58  ARG n 
1 59  LYS n 
1 60  SER n 
1 61  ASN n 
1 62  HIS n 
1 63  ASN n 
1 64  PHE n 
1 65  LEU n 
1 66  VAL n 
1 67  GLN n 
1 68  ALA n 
1 69  GLY n 
1 70  ASN n 
1 71  VAL n 
1 72  GLN n 
1 73  LEU n 
1 74  ARG n 
1 75  VAL n 
1 76  ILE n 
1 77  GLY n 
1 78  HIS n 
1 79  SER n 
1 80  MET n 
1 81  GLN n 
1 82  ASN n 
1 83  CYS n 
1 84  VAL n 
1 85  LEU n 
1 86  LYS n 
1 87  LEU n 
1 88  LYS n 
1 89  VAL n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  ASN n 
1 94  PRO n 
1 95  LYS n 
1 96  THR n 
1 97  PRO n 
1 98  LYS n 
1 99  TYR n 
1 100 LYS n 
1 101 PHE n 
1 102 VAL n 
1 103 ARG n 
1 104 ILE n 
1 105 GLN n 
1 106 PRO n 
1 107 GLY n 
1 108 GLN n 
1 109 THR n 
1 110 PHE n 
1 111 SER n 
1 112 VAL n 
1 113 LEU n 
1 114 ALA n 
1 115 CYS n 
1 116 TYR n 
1 117 ASN n 
1 118 GLY n 
1 119 SER n 
1 120 PRO n 
1 121 SER n 
1 122 GLY n 
1 123 VAL n 
1 124 TYR n 
1 125 GLN n 
1 126 CYS n 
1 127 ALA n 
1 128 MET n 
1 129 ARG n 
1 130 HIS n 
1 131 ASN n 
1 132 PHE n 
1 133 THR n 
1 134 ILE n 
1 135 LYS n 
1 136 GLY n 
1 137 SER n 
1 138 PHE n 
1 139 LEU n 
1 140 ASN n 
1 141 GLY n 
1 142 SER n 
1 143 CYS n 
1 144 GLY n 
1 145 SER n 
1 146 VAL n 
1 147 GLY n 
1 148 PHE n 
1 149 ASN n 
1 150 ILE n 
1 151 ASP n 
1 152 TYR n 
1 153 ASP n 
1 154 CYS n 
1 155 VAL n 
1 156 SER n 
1 157 PHE n 
1 158 CYS n 
1 159 TYR n 
1 160 MET n 
1 161 HIS n 
1 162 HIS n 
1 163 MET n 
1 164 GLU n 
1 165 LEU n 
1 166 PRO n 
1 167 THR n 
1 168 GLY n 
1 169 VAL n 
1 170 HIS n 
1 171 ALA n 
1 172 GLY n 
1 173 THR n 
1 174 ASP n 
1 175 LEU n 
1 176 GLU n 
1 177 GLY n 
1 178 ASN n 
1 179 PHE n 
1 180 TYR n 
1 181 GLY n 
1 182 PRO n 
1 183 PHE n 
1 184 VAL n 
1 185 ASP n 
1 186 ARG n 
1 187 GLN n 
1 188 THR n 
1 189 ALA n 
1 190 GLN n 
1 191 ALA n 
1 192 ALA n 
1 193 GLY n 
1 194 THR n 
1 195 ASP n 
1 196 THR n 
1 197 THR n 
1 198 ILE n 
1 199 THR n 
1 200 VAL n 
1 201 ASN n 
1 202 VAL n 
1 203 LEU n 
1 204 ALA n 
1 205 TRP n 
1 206 LEU n 
1 207 TYR n 
1 208 ALA n 
1 209 ALA n 
1 210 VAL n 
1 211 ILE n 
1 212 ASN n 
1 213 GLY n 
1 214 ASP n 
1 215 ARG n 
1 216 TRP n 
1 217 PHE n 
1 218 LEU n 
1 219 ASN n 
1 220 ARG n 
1 221 PHE n 
1 222 THR n 
1 223 THR n 
1 224 THR n 
1 225 LEU n 
1 226 ASN n 
1 227 ASP n 
1 228 PHE n 
1 229 ASN n 
1 230 LEU n 
1 231 VAL n 
1 232 ALA n 
1 233 MET n 
1 234 LYS n 
1 235 TYR n 
1 236 ASN n 
1 237 TYR n 
1 238 GLU n 
1 239 PRO n 
1 240 LEU n 
1 241 THR n 
1 242 GLN n 
1 243 ASP n 
1 244 HIS n 
1 245 VAL n 
1 246 ASP n 
1 247 ILE n 
1 248 LEU n 
1 249 GLY n 
1 250 PRO n 
1 251 LEU n 
1 252 SER n 
1 253 ALA n 
1 254 GLN n 
1 255 THR n 
1 256 GLY n 
1 257 ILE n 
1 258 ALA n 
1 259 VAL n 
1 260 LEU n 
1 261 ASP n 
1 262 MET n 
1 263 CYS n 
1 264 ALA n 
1 265 SER n 
1 266 LEU n 
1 267 LYS n 
1 268 GLU n 
1 269 LEU n 
1 270 LEU n 
1 271 GLN n 
1 272 ASN n 
1 273 GLY n 
1 274 MET n 
1 275 ASN n 
1 276 GLY n 
1 277 ARG n 
1 278 THR n 
1 279 ILE n 
1 280 LEU n 
1 281 GLY n 
1 282 SER n 
1 283 ALA n 
1 284 LEU n 
1 285 LEU n 
1 286 GLU n 
1 287 ASP n 
1 288 GLU n 
1 289 PHE n 
1 290 THR n 
1 291 PRO n 
1 292 PHE n 
1 293 ASP n 
1 294 VAL n 
1 295 VAL n 
1 296 ARG n 
1 297 GLN n 
1 298 CYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   298 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
X77 non-polymer         . 
'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' ? 'C27 H33 N5 O2'  
459.583 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PHE 1   3   3   PHE PHE A . n 
A 1 2   ARG 2   4   4   ARG ARG A . n 
A 1 3   LYS 3   5   5   LYS LYS A . n 
A 1 4   MET 4   6   6   MET MET A . n 
A 1 5   ALA 5   7   7   ALA ALA A . n 
A 1 6   PHE 6   8   8   PHE PHE A . n 
A 1 7   PRO 7   9   9   PRO PRO A . n 
A 1 8   SER 8   10  10  SER SER A . n 
A 1 9   GLY 9   11  11  GLY GLY A . n 
A 1 10  LYS 10  12  12  LYS LYS A . n 
A 1 11  VAL 11  13  13  VAL VAL A . n 
A 1 12  GLU 12  14  14  GLU GLU A . n 
A 1 13  GLY 13  15  15  GLY GLY A . n 
A 1 14  CYS 14  16  16  CYS CYS A . n 
A 1 15  MET 15  17  17  MET MET A . n 
A 1 16  VAL 16  18  18  VAL VAL A . n 
A 1 17  GLN 17  19  19  GLN GLN A . n 
A 1 18  VAL 18  20  20  VAL VAL A . n 
A 1 19  THR 19  21  21  THR THR A . n 
A 1 20  CYS 20  22  22  CYS CYS A . n 
A 1 21  GLY 21  23  23  GLY GLY A . n 
A 1 22  THR 22  24  24  THR THR A . n 
A 1 23  THR 23  25  25  THR THR A . n 
A 1 24  THR 24  26  26  THR THR A . n 
A 1 25  LEU 25  27  27  LEU LEU A . n 
A 1 26  ASN 26  28  28  ASN ASN A . n 
A 1 27  GLY 27  29  29  GLY GLY A . n 
A 1 28  LEU 28  30  30  LEU LEU A . n 
A 1 29  TRP 29  31  31  TRP TRP A . n 
A 1 30  LEU 30  32  32  LEU LEU A . n 
A 1 31  ASP 31  33  33  ASP ASP A . n 
A 1 32  ASP 32  34  34  ASP ASP A . n 
A 1 33  VAL 33  35  35  VAL VAL A . n 
A 1 34  VAL 34  36  36  VAL VAL A . n 
A 1 35  TYR 35  37  37  TYR TYR A . n 
A 1 36  CYS 36  38  38  CYS CYS A . n 
A 1 37  PRO 37  39  39  PRO PRO A . n 
A 1 38  ARG 38  40  40  ARG ARG A . n 
A 1 39  HIS 39  41  41  HIS HIS A . n 
A 1 40  VAL 40  42  42  VAL VAL A . n 
A 1 41  ILE 41  43  43  ILE ILE A . n 
A 1 42  CYS 42  44  44  CYS CYS A . n 
A 1 43  THR 43  45  45  THR THR A . n 
A 1 44  SER 44  46  46  SER SER A . n 
A 1 45  GLU 45  47  47  GLU GLU A . n 
A 1 46  ASP 46  48  48  ASP ASP A . n 
A 1 47  MET 47  49  49  MET MET A . n 
A 1 48  LEU 48  50  50  LEU LEU A . n 
A 1 49  ASN 49  51  51  ASN ASN A . n 
A 1 50  PRO 50  52  52  PRO PRO A . n 
A 1 51  ASN 51  53  53  ASN ASN A . n 
A 1 52  TYR 52  54  54  TYR TYR A . n 
A 1 53  GLU 53  55  55  GLU GLU A . n 
A 1 54  ASP 54  56  56  ASP ASP A . n 
A 1 55  LEU 55  57  57  LEU LEU A . n 
A 1 56  LEU 56  58  58  LEU LEU A . n 
A 1 57  ILE 57  59  59  ILE ILE A . n 
A 1 58  ARG 58  60  60  ARG ARG A . n 
A 1 59  LYS 59  61  61  LYS LYS A . n 
A 1 60  SER 60  62  62  SER SER A . n 
A 1 61  ASN 61  63  63  ASN ASN A . n 
A 1 62  HIS 62  64  64  HIS HIS A . n 
A 1 63  ASN 63  65  65  ASN ASN A . n 
A 1 64  PHE 64  66  66  PHE PHE A . n 
A 1 65  LEU 65  67  67  LEU LEU A . n 
A 1 66  VAL 66  68  68  VAL VAL A . n 
A 1 67  GLN 67  69  69  GLN GLN A . n 
A 1 68  ALA 68  70  70  ALA ALA A . n 
A 1 69  GLY 69  71  71  GLY GLY A . n 
A 1 70  ASN 70  72  72  ASN ASN A . n 
A 1 71  VAL 71  73  73  VAL VAL A . n 
A 1 72  GLN 72  74  74  GLN GLN A . n 
A 1 73  LEU 73  75  75  LEU LEU A . n 
A 1 74  ARG 74  76  76  ARG ARG A . n 
A 1 75  VAL 75  77  77  VAL VAL A . n 
A 1 76  ILE 76  78  78  ILE ILE A . n 
A 1 77  GLY 77  79  79  GLY GLY A . n 
A 1 78  HIS 78  80  80  HIS HIS A . n 
A 1 79  SER 79  81  81  SER SER A . n 
A 1 80  MET 80  82  82  MET MET A . n 
A 1 81  GLN 81  83  83  GLN GLN A . n 
A 1 82  ASN 82  84  84  ASN ASN A . n 
A 1 83  CYS 83  85  85  CYS CYS A . n 
A 1 84  VAL 84  86  86  VAL VAL A . n 
A 1 85  LEU 85  87  87  LEU LEU A . n 
A 1 86  LYS 86  88  88  LYS LYS A . n 
A 1 87  LEU 87  89  89  LEU LEU A . n 
A 1 88  LYS 88  90  90  LYS LYS A . n 
A 1 89  VAL 89  91  91  VAL VAL A . n 
A 1 90  ASP 90  92  92  ASP ASP A . n 
A 1 91  THR 91  93  93  THR THR A . n 
A 1 92  ALA 92  94  94  ALA ALA A . n 
A 1 93  ASN 93  95  95  ASN ASN A . n 
A 1 94  PRO 94  96  96  PRO PRO A . n 
A 1 95  LYS 95  97  97  LYS LYS A . n 
A 1 96  THR 96  98  98  THR THR A . n 
A 1 97  PRO 97  99  99  PRO PRO A . n 
A 1 98  LYS 98  100 100 LYS LYS A . n 
A 1 99  TYR 99  101 101 TYR TYR A . n 
A 1 100 LYS 100 102 102 LYS LYS A . n 
A 1 101 PHE 101 103 103 PHE PHE A . n 
A 1 102 VAL 102 104 104 VAL VAL A . n 
A 1 103 ARG 103 105 105 ARG ARG A . n 
A 1 104 ILE 104 106 106 ILE ILE A . n 
A 1 105 GLN 105 107 107 GLN GLN A . n 
A 1 106 PRO 106 108 108 PRO PRO A . n 
A 1 107 GLY 107 109 109 GLY GLY A . n 
A 1 108 GLN 108 110 110 GLN GLN A . n 
A 1 109 THR 109 111 111 THR THR A . n 
A 1 110 PHE 110 112 112 PHE PHE A . n 
A 1 111 SER 111 113 113 SER SER A . n 
A 1 112 VAL 112 114 114 VAL VAL A . n 
A 1 113 LEU 113 115 115 LEU LEU A . n 
A 1 114 ALA 114 116 116 ALA ALA A . n 
A 1 115 CYS 115 117 117 CYS CYS A . n 
A 1 116 TYR 116 118 118 TYR TYR A . n 
A 1 117 ASN 117 119 119 ASN ASN A . n 
A 1 118 GLY 118 120 120 GLY GLY A . n 
A 1 119 SER 119 121 121 SER SER A . n 
A 1 120 PRO 120 122 122 PRO PRO A . n 
A 1 121 SER 121 123 123 SER SER A . n 
A 1 122 GLY 122 124 124 GLY GLY A . n 
A 1 123 VAL 123 125 125 VAL VAL A . n 
A 1 124 TYR 124 126 126 TYR TYR A . n 
A 1 125 GLN 125 127 127 GLN GLN A . n 
A 1 126 CYS 126 128 128 CYS CYS A . n 
A 1 127 ALA 127 129 129 ALA ALA A . n 
A 1 128 MET 128 130 130 MET MET A . n 
A 1 129 ARG 129 131 131 ARG ARG A . n 
A 1 130 HIS 130 132 132 HIS HIS A . n 
A 1 131 ASN 131 133 133 ASN ASN A . n 
A 1 132 PHE 132 134 134 PHE PHE A . n 
A 1 133 THR 133 135 135 THR THR A . n 
A 1 134 ILE 134 136 136 ILE ILE A . n 
A 1 135 LYS 135 137 137 LYS LYS A . n 
A 1 136 GLY 136 138 138 GLY GLY A . n 
A 1 137 SER 137 139 139 SER SER A . n 
A 1 138 PHE 138 140 140 PHE PHE A . n 
A 1 139 LEU 139 141 141 LEU LEU A . n 
A 1 140 ASN 140 142 142 ASN ASN A . n 
A 1 141 GLY 141 143 143 GLY GLY A . n 
A 1 142 SER 142 144 144 SER SER A . n 
A 1 143 CYS 143 145 145 CYS CYS A . n 
A 1 144 GLY 144 146 146 GLY GLY A . n 
A 1 145 SER 145 147 147 SER SER A . n 
A 1 146 VAL 146 148 148 VAL VAL A . n 
A 1 147 GLY 147 149 149 GLY GLY A . n 
A 1 148 PHE 148 150 150 PHE PHE A . n 
A 1 149 ASN 149 151 151 ASN ASN A . n 
A 1 150 ILE 150 152 152 ILE ILE A . n 
A 1 151 ASP 151 153 153 ASP ASP A . n 
A 1 152 TYR 152 154 154 TYR TYR A . n 
A 1 153 ASP 153 155 155 ASP ASP A . n 
A 1 154 CYS 154 156 156 CYS CYS A . n 
A 1 155 VAL 155 157 157 VAL VAL A . n 
A 1 156 SER 156 158 158 SER SER A . n 
A 1 157 PHE 157 159 159 PHE PHE A . n 
A 1 158 CYS 158 160 160 CYS CYS A . n 
A 1 159 TYR 159 161 161 TYR TYR A . n 
A 1 160 MET 160 162 162 MET MET A . n 
A 1 161 HIS 161 163 163 HIS HIS A . n 
A 1 162 HIS 162 164 164 HIS HIS A . n 
A 1 163 MET 163 165 165 MET MET A . n 
A 1 164 GLU 164 166 166 GLU GLU A . n 
A 1 165 LEU 165 167 167 LEU LEU A . n 
A 1 166 PRO 166 168 168 PRO PRO A . n 
A 1 167 THR 167 169 169 THR THR A . n 
A 1 168 GLY 168 170 170 GLY GLY A . n 
A 1 169 VAL 169 171 171 VAL VAL A . n 
A 1 170 HIS 170 172 172 HIS HIS A . n 
A 1 171 ALA 171 173 173 ALA ALA A . n 
A 1 172 GLY 172 174 174 GLY GLY A . n 
A 1 173 THR 173 175 175 THR THR A . n 
A 1 174 ASP 174 176 176 ASP ASP A . n 
A 1 175 LEU 175 177 177 LEU LEU A . n 
A 1 176 GLU 176 178 178 GLU GLU A . n 
A 1 177 GLY 177 179 179 GLY GLY A . n 
A 1 178 ASN 178 180 180 ASN ASN A . n 
A 1 179 PHE 179 181 181 PHE PHE A . n 
A 1 180 TYR 180 182 182 TYR TYR A . n 
A 1 181 GLY 181 183 183 GLY GLY A . n 
A 1 182 PRO 182 184 184 PRO PRO A . n 
A 1 183 PHE 183 185 185 PHE PHE A . n 
A 1 184 VAL 184 186 186 VAL VAL A . n 
A 1 185 ASP 185 187 187 ASP ASP A . n 
A 1 186 ARG 186 188 188 ARG ARG A . n 
A 1 187 GLN 187 189 189 GLN GLN A . n 
A 1 188 THR 188 190 190 THR THR A . n 
A 1 189 ALA 189 191 191 ALA ALA A . n 
A 1 190 GLN 190 192 192 GLN GLN A . n 
A 1 191 ALA 191 193 193 ALA ALA A . n 
A 1 192 ALA 192 194 194 ALA ALA A . n 
A 1 193 GLY 193 195 195 GLY GLY A . n 
A 1 194 THR 194 196 196 THR THR A . n 
A 1 195 ASP 195 197 197 ASP ASP A . n 
A 1 196 THR 196 198 198 THR THR A . n 
A 1 197 THR 197 199 199 THR THR A . n 
A 1 198 ILE 198 200 200 ILE ILE A . n 
A 1 199 THR 199 201 201 THR THR A . n 
A 1 200 VAL 200 202 202 VAL VAL A . n 
A 1 201 ASN 201 203 203 ASN ASN A . n 
A 1 202 VAL 202 204 204 VAL VAL A . n 
A 1 203 LEU 203 205 205 LEU LEU A . n 
A 1 204 ALA 204 206 206 ALA ALA A . n 
A 1 205 TRP 205 207 207 TRP TRP A . n 
A 1 206 LEU 206 208 208 LEU LEU A . n 
A 1 207 TYR 207 209 209 TYR TYR A . n 
A 1 208 ALA 208 210 210 ALA ALA A . n 
A 1 209 ALA 209 211 211 ALA ALA A . n 
A 1 210 VAL 210 212 212 VAL VAL A . n 
A 1 211 ILE 211 213 213 ILE ILE A . n 
A 1 212 ASN 212 214 214 ASN ASN A . n 
A 1 213 GLY 213 215 215 GLY GLY A . n 
A 1 214 ASP 214 216 216 ASP ASP A . n 
A 1 215 ARG 215 217 217 ARG ARG A . n 
A 1 216 TRP 216 218 218 TRP TRP A . n 
A 1 217 PHE 217 219 219 PHE PHE A . n 
A 1 218 LEU 218 220 220 LEU LEU A . n 
A 1 219 ASN 219 221 221 ASN ASN A . n 
A 1 220 ARG 220 222 222 ARG ARG A . n 
A 1 221 PHE 221 223 223 PHE PHE A . n 
A 1 222 THR 222 224 224 THR THR A . n 
A 1 223 THR 223 225 225 THR THR A . n 
A 1 224 THR 224 226 226 THR THR A . n 
A 1 225 LEU 225 227 227 LEU LEU A . n 
A 1 226 ASN 226 228 228 ASN ASN A . n 
A 1 227 ASP 227 229 229 ASP ASP A . n 
A 1 228 PHE 228 230 230 PHE PHE A . n 
A 1 229 ASN 229 231 231 ASN ASN A . n 
A 1 230 LEU 230 232 232 LEU LEU A . n 
A 1 231 VAL 231 233 233 VAL VAL A . n 
A 1 232 ALA 232 234 234 ALA ALA A . n 
A 1 233 MET 233 235 235 MET MET A . n 
A 1 234 LYS 234 236 236 LYS LYS A . n 
A 1 235 TYR 235 237 237 TYR TYR A . n 
A 1 236 ASN 236 238 238 ASN ASN A . n 
A 1 237 TYR 237 239 239 TYR TYR A . n 
A 1 238 GLU 238 240 240 GLU GLU A . n 
A 1 239 PRO 239 241 241 PRO PRO A . n 
A 1 240 LEU 240 242 242 LEU LEU A . n 
A 1 241 THR 241 243 243 THR THR A . n 
A 1 242 GLN 242 244 244 GLN GLN A . n 
A 1 243 ASP 243 245 245 ASP ASP A . n 
A 1 244 HIS 244 246 246 HIS HIS A . n 
A 1 245 VAL 245 247 247 VAL VAL A . n 
A 1 246 ASP 246 248 248 ASP ASP A . n 
A 1 247 ILE 247 249 249 ILE ILE A . n 
A 1 248 LEU 248 250 250 LEU LEU A . n 
A 1 249 GLY 249 251 251 GLY GLY A . n 
A 1 250 PRO 250 252 252 PRO PRO A . n 
A 1 251 LEU 251 253 253 LEU LEU A . n 
A 1 252 SER 252 254 254 SER SER A . n 
A 1 253 ALA 253 255 255 ALA ALA A . n 
A 1 254 GLN 254 256 256 GLN GLN A . n 
A 1 255 THR 255 257 257 THR THR A . n 
A 1 256 GLY 256 258 258 GLY GLY A . n 
A 1 257 ILE 257 259 259 ILE ILE A . n 
A 1 258 ALA 258 260 260 ALA ALA A . n 
A 1 259 VAL 259 261 261 VAL VAL A . n 
A 1 260 LEU 260 262 262 LEU LEU A . n 
A 1 261 ASP 261 263 263 ASP ASP A . n 
A 1 262 MET 262 264 264 MET MET A . n 
A 1 263 CYS 263 265 265 CYS CYS A . n 
A 1 264 ALA 264 266 266 ALA ALA A . n 
A 1 265 SER 265 267 267 SER SER A . n 
A 1 266 LEU 266 268 268 LEU LEU A . n 
A 1 267 LYS 267 269 269 LYS LYS A . n 
A 1 268 GLU 268 270 270 GLU GLU A . n 
A 1 269 LEU 269 271 271 LEU LEU A . n 
A 1 270 LEU 270 272 272 LEU LEU A . n 
A 1 271 GLN 271 273 273 GLN GLN A . n 
A 1 272 ASN 272 274 274 ASN ASN A . n 
A 1 273 GLY 273 275 275 GLY GLY A . n 
A 1 274 MET 274 276 276 MET MET A . n 
A 1 275 ASN 275 277 277 ASN ASN A . n 
A 1 276 GLY 276 278 278 GLY GLY A . n 
A 1 277 ARG 277 279 279 ARG ARG A . n 
A 1 278 THR 278 280 280 THR THR A . n 
A 1 279 ILE 279 281 281 ILE ILE A . n 
A 1 280 LEU 280 282 282 LEU LEU A . n 
A 1 281 GLY 281 283 283 GLY GLY A . n 
A 1 282 SER 282 284 284 SER SER A . n 
A 1 283 ALA 283 285 285 ALA ALA A . n 
A 1 284 LEU 284 286 286 LEU LEU A . n 
A 1 285 LEU 285 287 287 LEU LEU A . n 
A 1 286 GLU 286 288 288 GLU GLU A . n 
A 1 287 ASP 287 289 289 ASP ASP A . n 
A 1 288 GLU 288 290 290 GLU GLU A . n 
A 1 289 PHE 289 291 291 PHE PHE A . n 
A 1 290 THR 290 292 292 THR THR A . n 
A 1 291 PRO 291 293 293 PRO PRO A . n 
A 1 292 PHE 292 294 294 PHE PHE A . n 
A 1 293 ASP 293 295 295 ASP ASP A . n 
A 1 294 VAL 294 296 296 VAL VAL A . n 
A 1 295 VAL 295 297 297 VAL VAL A . n 
A 1 296 ARG 296 298 298 ARG ARG A . n 
A 1 297 GLN 297 299 299 GLN GLN A . n 
A 1 298 CYS 298 300 300 CYS CYS A . n 
B 1 1   PHE 1   3   3   PHE PHE B . n 
B 1 2   ARG 2   4   4   ARG ARG B . n 
B 1 3   LYS 3   5   5   LYS LYS B . n 
B 1 4   MET 4   6   6   MET MET B . n 
B 1 5   ALA 5   7   7   ALA ALA B . n 
B 1 6   PHE 6   8   8   PHE PHE B . n 
B 1 7   PRO 7   9   9   PRO PRO B . n 
B 1 8   SER 8   10  10  SER SER B . n 
B 1 9   GLY 9   11  11  GLY GLY B . n 
B 1 10  LYS 10  12  12  LYS LYS B . n 
B 1 11  VAL 11  13  13  VAL VAL B . n 
B 1 12  GLU 12  14  14  GLU GLU B . n 
B 1 13  GLY 13  15  15  GLY GLY B . n 
B 1 14  CYS 14  16  16  CYS CYS B . n 
B 1 15  MET 15  17  17  MET MET B . n 
B 1 16  VAL 16  18  18  VAL VAL B . n 
B 1 17  GLN 17  19  19  GLN GLN B . n 
B 1 18  VAL 18  20  20  VAL VAL B . n 
B 1 19  THR 19  21  21  THR THR B . n 
B 1 20  CYS 20  22  22  CYS CYS B . n 
B 1 21  GLY 21  23  23  GLY GLY B . n 
B 1 22  THR 22  24  24  THR THR B . n 
B 1 23  THR 23  25  25  THR THR B . n 
B 1 24  THR 24  26  26  THR THR B . n 
B 1 25  LEU 25  27  27  LEU LEU B . n 
B 1 26  ASN 26  28  28  ASN ASN B . n 
B 1 27  GLY 27  29  29  GLY GLY B . n 
B 1 28  LEU 28  30  30  LEU LEU B . n 
B 1 29  TRP 29  31  31  TRP TRP B . n 
B 1 30  LEU 30  32  32  LEU LEU B . n 
B 1 31  ASP 31  33  33  ASP ASP B . n 
B 1 32  ASP 32  34  34  ASP ASP B . n 
B 1 33  VAL 33  35  35  VAL VAL B . n 
B 1 34  VAL 34  36  36  VAL VAL B . n 
B 1 35  TYR 35  37  37  TYR TYR B . n 
B 1 36  CYS 36  38  38  CYS CYS B . n 
B 1 37  PRO 37  39  39  PRO PRO B . n 
B 1 38  ARG 38  40  40  ARG ARG B . n 
B 1 39  HIS 39  41  41  HIS HIS B . n 
B 1 40  VAL 40  42  42  VAL VAL B . n 
B 1 41  ILE 41  43  43  ILE ILE B . n 
B 1 42  CYS 42  44  44  CYS CYS B . n 
B 1 43  THR 43  45  45  THR THR B . n 
B 1 44  SER 44  46  46  SER SER B . n 
B 1 45  GLU 45  47  47  GLU GLU B . n 
B 1 46  ASP 46  48  48  ASP ASP B . n 
B 1 47  MET 47  49  49  MET MET B . n 
B 1 48  LEU 48  50  50  LEU LEU B . n 
B 1 49  ASN 49  51  51  ASN ASN B . n 
B 1 50  PRO 50  52  52  PRO PRO B . n 
B 1 51  ASN 51  53  53  ASN ASN B . n 
B 1 52  TYR 52  54  54  TYR TYR B . n 
B 1 53  GLU 53  55  55  GLU GLU B . n 
B 1 54  ASP 54  56  56  ASP ASP B . n 
B 1 55  LEU 55  57  57  LEU LEU B . n 
B 1 56  LEU 56  58  58  LEU LEU B . n 
B 1 57  ILE 57  59  59  ILE ILE B . n 
B 1 58  ARG 58  60  60  ARG ARG B . n 
B 1 59  LYS 59  61  61  LYS LYS B . n 
B 1 60  SER 60  62  62  SER SER B . n 
B 1 61  ASN 61  63  63  ASN ASN B . n 
B 1 62  HIS 62  64  64  HIS HIS B . n 
B 1 63  ASN 63  65  65  ASN ASN B . n 
B 1 64  PHE 64  66  66  PHE PHE B . n 
B 1 65  LEU 65  67  67  LEU LEU B . n 
B 1 66  VAL 66  68  68  VAL VAL B . n 
B 1 67  GLN 67  69  69  GLN GLN B . n 
B 1 68  ALA 68  70  70  ALA ALA B . n 
B 1 69  GLY 69  71  71  GLY GLY B . n 
B 1 70  ASN 70  72  72  ASN ASN B . n 
B 1 71  VAL 71  73  73  VAL VAL B . n 
B 1 72  GLN 72  74  74  GLN GLN B . n 
B 1 73  LEU 73  75  75  LEU LEU B . n 
B 1 74  ARG 74  76  76  ARG ARG B . n 
B 1 75  VAL 75  77  77  VAL VAL B . n 
B 1 76  ILE 76  78  78  ILE ILE B . n 
B 1 77  GLY 77  79  79  GLY GLY B . n 
B 1 78  HIS 78  80  80  HIS HIS B . n 
B 1 79  SER 79  81  81  SER SER B . n 
B 1 80  MET 80  82  82  MET MET B . n 
B 1 81  GLN 81  83  83  GLN GLN B . n 
B 1 82  ASN 82  84  84  ASN ASN B . n 
B 1 83  CYS 83  85  85  CYS CYS B . n 
B 1 84  VAL 84  86  86  VAL VAL B . n 
B 1 85  LEU 85  87  87  LEU LEU B . n 
B 1 86  LYS 86  88  88  LYS LYS B . n 
B 1 87  LEU 87  89  89  LEU LEU B . n 
B 1 88  LYS 88  90  90  LYS LYS B . n 
B 1 89  VAL 89  91  91  VAL VAL B . n 
B 1 90  ASP 90  92  92  ASP ASP B . n 
B 1 91  THR 91  93  93  THR THR B . n 
B 1 92  ALA 92  94  94  ALA ALA B . n 
B 1 93  ASN 93  95  95  ASN ASN B . n 
B 1 94  PRO 94  96  96  PRO PRO B . n 
B 1 95  LYS 95  97  97  LYS LYS B . n 
B 1 96  THR 96  98  98  THR THR B . n 
B 1 97  PRO 97  99  99  PRO PRO B . n 
B 1 98  LYS 98  100 100 LYS LYS B . n 
B 1 99  TYR 99  101 101 TYR TYR B . n 
B 1 100 LYS 100 102 102 LYS LYS B . n 
B 1 101 PHE 101 103 103 PHE PHE B . n 
B 1 102 VAL 102 104 104 VAL VAL B . n 
B 1 103 ARG 103 105 105 ARG ARG B . n 
B 1 104 ILE 104 106 106 ILE ILE B . n 
B 1 105 GLN 105 107 107 GLN GLN B . n 
B 1 106 PRO 106 108 108 PRO PRO B . n 
B 1 107 GLY 107 109 109 GLY GLY B . n 
B 1 108 GLN 108 110 110 GLN GLN B . n 
B 1 109 THR 109 111 111 THR THR B . n 
B 1 110 PHE 110 112 112 PHE PHE B . n 
B 1 111 SER 111 113 113 SER SER B . n 
B 1 112 VAL 112 114 114 VAL VAL B . n 
B 1 113 LEU 113 115 115 LEU LEU B . n 
B 1 114 ALA 114 116 116 ALA ALA B . n 
B 1 115 CYS 115 117 117 CYS CYS B . n 
B 1 116 TYR 116 118 118 TYR TYR B . n 
B 1 117 ASN 117 119 119 ASN ASN B . n 
B 1 118 GLY 118 120 120 GLY GLY B . n 
B 1 119 SER 119 121 121 SER SER B . n 
B 1 120 PRO 120 122 122 PRO PRO B . n 
B 1 121 SER 121 123 123 SER SER B . n 
B 1 122 GLY 122 124 124 GLY GLY B . n 
B 1 123 VAL 123 125 125 VAL VAL B . n 
B 1 124 TYR 124 126 126 TYR TYR B . n 
B 1 125 GLN 125 127 127 GLN GLN B . n 
B 1 126 CYS 126 128 128 CYS CYS B . n 
B 1 127 ALA 127 129 129 ALA ALA B . n 
B 1 128 MET 128 130 130 MET MET B . n 
B 1 129 ARG 129 131 131 ARG ARG B . n 
B 1 130 HIS 130 132 132 HIS HIS B . n 
B 1 131 ASN 131 133 133 ASN ASN B . n 
B 1 132 PHE 132 134 134 PHE PHE B . n 
B 1 133 THR 133 135 135 THR THR B . n 
B 1 134 ILE 134 136 136 ILE ILE B . n 
B 1 135 LYS 135 137 137 LYS LYS B . n 
B 1 136 GLY 136 138 138 GLY GLY B . n 
B 1 137 SER 137 139 139 SER SER B . n 
B 1 138 PHE 138 140 140 PHE PHE B . n 
B 1 139 LEU 139 141 141 LEU LEU B . n 
B 1 140 ASN 140 142 142 ASN ASN B . n 
B 1 141 GLY 141 143 143 GLY GLY B . n 
B 1 142 SER 142 144 144 SER SER B . n 
B 1 143 CYS 143 145 145 CYS CYS B . n 
B 1 144 GLY 144 146 146 GLY GLY B . n 
B 1 145 SER 145 147 147 SER SER B . n 
B 1 146 VAL 146 148 148 VAL VAL B . n 
B 1 147 GLY 147 149 149 GLY GLY B . n 
B 1 148 PHE 148 150 150 PHE PHE B . n 
B 1 149 ASN 149 151 151 ASN ASN B . n 
B 1 150 ILE 150 152 152 ILE ILE B . n 
B 1 151 ASP 151 153 153 ASP ASP B . n 
B 1 152 TYR 152 154 154 TYR TYR B . n 
B 1 153 ASP 153 155 155 ASP ASP B . n 
B 1 154 CYS 154 156 156 CYS CYS B . n 
B 1 155 VAL 155 157 157 VAL VAL B . n 
B 1 156 SER 156 158 158 SER SER B . n 
B 1 157 PHE 157 159 159 PHE PHE B . n 
B 1 158 CYS 158 160 160 CYS CYS B . n 
B 1 159 TYR 159 161 161 TYR TYR B . n 
B 1 160 MET 160 162 162 MET MET B . n 
B 1 161 HIS 161 163 163 HIS HIS B . n 
B 1 162 HIS 162 164 164 HIS HIS B . n 
B 1 163 MET 163 165 165 MET MET B . n 
B 1 164 GLU 164 166 166 GLU GLU B . n 
B 1 165 LEU 165 167 167 LEU LEU B . n 
B 1 166 PRO 166 168 168 PRO PRO B . n 
B 1 167 THR 167 169 169 THR THR B . n 
B 1 168 GLY 168 170 170 GLY GLY B . n 
B 1 169 VAL 169 171 171 VAL VAL B . n 
B 1 170 HIS 170 172 172 HIS HIS B . n 
B 1 171 ALA 171 173 173 ALA ALA B . n 
B 1 172 GLY 172 174 174 GLY GLY B . n 
B 1 173 THR 173 175 175 THR THR B . n 
B 1 174 ASP 174 176 176 ASP ASP B . n 
B 1 175 LEU 175 177 177 LEU LEU B . n 
B 1 176 GLU 176 178 178 GLU GLU B . n 
B 1 177 GLY 177 179 179 GLY GLY B . n 
B 1 178 ASN 178 180 180 ASN ASN B . n 
B 1 179 PHE 179 181 181 PHE PHE B . n 
B 1 180 TYR 180 182 182 TYR TYR B . n 
B 1 181 GLY 181 183 183 GLY GLY B . n 
B 1 182 PRO 182 184 184 PRO PRO B . n 
B 1 183 PHE 183 185 185 PHE PHE B . n 
B 1 184 VAL 184 186 186 VAL VAL B . n 
B 1 185 ASP 185 187 187 ASP ASP B . n 
B 1 186 ARG 186 188 188 ARG ARG B . n 
B 1 187 GLN 187 189 189 GLN GLN B . n 
B 1 188 THR 188 190 190 THR THR B . n 
B 1 189 ALA 189 191 191 ALA ALA B . n 
B 1 190 GLN 190 192 192 GLN GLN B . n 
B 1 191 ALA 191 193 193 ALA ALA B . n 
B 1 192 ALA 192 194 194 ALA ALA B . n 
B 1 193 GLY 193 195 195 GLY GLY B . n 
B 1 194 THR 194 196 196 THR THR B . n 
B 1 195 ASP 195 197 197 ASP ASP B . n 
B 1 196 THR 196 198 198 THR THR B . n 
B 1 197 THR 197 199 199 THR THR B . n 
B 1 198 ILE 198 200 200 ILE ILE B . n 
B 1 199 THR 199 201 201 THR THR B . n 
B 1 200 VAL 200 202 202 VAL VAL B . n 
B 1 201 ASN 201 203 203 ASN ASN B . n 
B 1 202 VAL 202 204 204 VAL VAL B . n 
B 1 203 LEU 203 205 205 LEU LEU B . n 
B 1 204 ALA 204 206 206 ALA ALA B . n 
B 1 205 TRP 205 207 207 TRP TRP B . n 
B 1 206 LEU 206 208 208 LEU LEU B . n 
B 1 207 TYR 207 209 209 TYR TYR B . n 
B 1 208 ALA 208 210 210 ALA ALA B . n 
B 1 209 ALA 209 211 211 ALA ALA B . n 
B 1 210 VAL 210 212 212 VAL VAL B . n 
B 1 211 ILE 211 213 213 ILE ILE B . n 
B 1 212 ASN 212 214 214 ASN ASN B . n 
B 1 213 GLY 213 215 215 GLY GLY B . n 
B 1 214 ASP 214 216 216 ASP ASP B . n 
B 1 215 ARG 215 217 217 ARG ARG B . n 
B 1 216 TRP 216 218 218 TRP TRP B . n 
B 1 217 PHE 217 219 219 PHE PHE B . n 
B 1 218 LEU 218 220 220 LEU LEU B . n 
B 1 219 ASN 219 221 221 ASN ASN B . n 
B 1 220 ARG 220 222 222 ARG ARG B . n 
B 1 221 PHE 221 223 223 PHE PHE B . n 
B 1 222 THR 222 224 224 THR THR B . n 
B 1 223 THR 223 225 225 THR THR B . n 
B 1 224 THR 224 226 226 THR THR B . n 
B 1 225 LEU 225 227 227 LEU LEU B . n 
B 1 226 ASN 226 228 228 ASN ASN B . n 
B 1 227 ASP 227 229 229 ASP ASP B . n 
B 1 228 PHE 228 230 230 PHE PHE B . n 
B 1 229 ASN 229 231 231 ASN ASN B . n 
B 1 230 LEU 230 232 232 LEU LEU B . n 
B 1 231 VAL 231 233 233 VAL VAL B . n 
B 1 232 ALA 232 234 234 ALA ALA B . n 
B 1 233 MET 233 235 235 MET MET B . n 
B 1 234 LYS 234 236 236 LYS LYS B . n 
B 1 235 TYR 235 237 237 TYR TYR B . n 
B 1 236 ASN 236 238 238 ASN ASN B . n 
B 1 237 TYR 237 239 239 TYR TYR B . n 
B 1 238 GLU 238 240 240 GLU GLU B . n 
B 1 239 PRO 239 241 241 PRO PRO B . n 
B 1 240 LEU 240 242 242 LEU LEU B . n 
B 1 241 THR 241 243 243 THR THR B . n 
B 1 242 GLN 242 244 244 GLN GLN B . n 
B 1 243 ASP 243 245 245 ASP ASP B . n 
B 1 244 HIS 244 246 246 HIS HIS B . n 
B 1 245 VAL 245 247 247 VAL VAL B . n 
B 1 246 ASP 246 248 248 ASP ASP B . n 
B 1 247 ILE 247 249 249 ILE ILE B . n 
B 1 248 LEU 248 250 250 LEU LEU B . n 
B 1 249 GLY 249 251 251 GLY GLY B . n 
B 1 250 PRO 250 252 252 PRO PRO B . n 
B 1 251 LEU 251 253 253 LEU LEU B . n 
B 1 252 SER 252 254 254 SER SER B . n 
B 1 253 ALA 253 255 255 ALA ALA B . n 
B 1 254 GLN 254 256 256 GLN GLN B . n 
B 1 255 THR 255 257 257 THR THR B . n 
B 1 256 GLY 256 258 258 GLY GLY B . n 
B 1 257 ILE 257 259 259 ILE ILE B . n 
B 1 258 ALA 258 260 260 ALA ALA B . n 
B 1 259 VAL 259 261 261 VAL VAL B . n 
B 1 260 LEU 260 262 262 LEU LEU B . n 
B 1 261 ASP 261 263 263 ASP ASP B . n 
B 1 262 MET 262 264 264 MET MET B . n 
B 1 263 CYS 263 265 265 CYS CYS B . n 
B 1 264 ALA 264 266 266 ALA ALA B . n 
B 1 265 SER 265 267 267 SER SER B . n 
B 1 266 LEU 266 268 268 LEU LEU B . n 
B 1 267 LYS 267 269 269 LYS LYS B . n 
B 1 268 GLU 268 270 270 GLU GLU B . n 
B 1 269 LEU 269 271 271 LEU LEU B . n 
B 1 270 LEU 270 272 ?   ?   ?   B . n 
B 1 271 GLN 271 273 ?   ?   ?   B . n 
B 1 272 ASN 272 274 ?   ?   ?   B . n 
B 1 273 GLY 273 275 ?   ?   ?   B . n 
B 1 274 MET 274 276 ?   ?   ?   B . n 
B 1 275 ASN 275 277 ?   ?   ?   B . n 
B 1 276 GLY 276 278 ?   ?   ?   B . n 
B 1 277 ARG 277 279 ?   ?   ?   B . n 
B 1 278 THR 278 280 280 THR THR B . n 
B 1 279 ILE 279 281 281 ILE ILE B . n 
B 1 280 LEU 280 282 282 LEU LEU B . n 
B 1 281 GLY 281 283 283 GLY GLY B . n 
B 1 282 SER 282 284 284 SER SER B . n 
B 1 283 ALA 283 285 285 ALA ALA B . n 
B 1 284 LEU 284 286 286 LEU LEU B . n 
B 1 285 LEU 285 287 287 LEU LEU B . n 
B 1 286 GLU 286 288 288 GLU GLU B . n 
B 1 287 ASP 287 289 289 ASP ASP B . n 
B 1 288 GLU 288 290 290 GLU GLU B . n 
B 1 289 PHE 289 291 291 PHE PHE B . n 
B 1 290 THR 290 292 292 THR THR B . n 
B 1 291 PRO 291 293 293 PRO PRO B . n 
B 1 292 PHE 292 294 294 PHE PHE B . n 
B 1 293 ASP 293 295 295 ASP ASP B . n 
B 1 294 VAL 294 296 296 VAL VAL B . n 
B 1 295 VAL 295 297 297 VAL VAL B . n 
B 1 296 ARG 296 298 298 ARG ARG B . n 
B 1 297 GLN 297 299 299 GLN GLN B . n 
B 1 298 CYS 298 300 300 CYS CYS B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X77 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X77 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 X77 1   401 1   X77 LIG A . 
D 2 X77 1   401 2   X77 LIG B . 
E 3 HOH 1   501 137 HOH HOH A . 
E 3 HOH 2   502 44  HOH HOH A . 
E 3 HOH 3   503 7   HOH HOH A . 
E 3 HOH 4   504 105 HOH HOH A . 
E 3 HOH 5   505 154 HOH HOH A . 
E 3 HOH 6   506 156 HOH HOH A . 
E 3 HOH 7   507 71  HOH HOH A . 
E 3 HOH 8   508 97  HOH HOH A . 
E 3 HOH 9   509 78  HOH HOH A . 
E 3 HOH 10  510 75  HOH HOH A . 
E 3 HOH 11  511 11  HOH HOH A . 
E 3 HOH 12  512 83  HOH HOH A . 
E 3 HOH 13  513 145 HOH HOH A . 
E 3 HOH 14  514 1   HOH HOH A . 
E 3 HOH 15  515 98  HOH HOH A . 
E 3 HOH 16  516 50  HOH HOH A . 
E 3 HOH 17  517 149 HOH HOH A . 
E 3 HOH 18  518 136 HOH HOH A . 
E 3 HOH 19  519 25  HOH HOH A . 
E 3 HOH 20  520 89  HOH HOH A . 
E 3 HOH 21  521 122 HOH HOH A . 
E 3 HOH 22  522 21  HOH HOH A . 
E 3 HOH 23  523 109 HOH HOH A . 
E 3 HOH 24  524 165 HOH HOH A . 
E 3 HOH 25  525 77  HOH HOH A . 
E 3 HOH 26  526 40  HOH HOH A . 
E 3 HOH 27  527 58  HOH HOH A . 
E 3 HOH 28  528 18  HOH HOH A . 
E 3 HOH 29  529 10  HOH HOH A . 
E 3 HOH 30  530 88  HOH HOH A . 
E 3 HOH 31  531 153 HOH HOH A . 
E 3 HOH 32  532 116 HOH HOH A . 
E 3 HOH 33  533 111 HOH HOH A . 
E 3 HOH 34  534 120 HOH HOH A . 
E 3 HOH 35  535 163 HOH HOH A . 
E 3 HOH 36  536 92  HOH HOH A . 
E 3 HOH 37  537 118 HOH HOH A . 
E 3 HOH 38  538 100 HOH HOH A . 
E 3 HOH 39  539 84  HOH HOH A . 
E 3 HOH 40  540 69  HOH HOH A . 
E 3 HOH 41  541 6   HOH HOH A . 
E 3 HOH 42  542 143 HOH HOH A . 
E 3 HOH 43  543 61  HOH HOH A . 
E 3 HOH 44  544 101 HOH HOH A . 
E 3 HOH 45  545 27  HOH HOH A . 
E 3 HOH 46  546 72  HOH HOH A . 
E 3 HOH 47  547 9   HOH HOH A . 
E 3 HOH 48  548 95  HOH HOH A . 
E 3 HOH 49  549 12  HOH HOH A . 
E 3 HOH 50  550 29  HOH HOH A . 
E 3 HOH 51  551 138 HOH HOH A . 
E 3 HOH 52  552 14  HOH HOH A . 
E 3 HOH 53  553 63  HOH HOH A . 
E 3 HOH 54  554 125 HOH HOH A . 
E 3 HOH 55  555 24  HOH HOH A . 
E 3 HOH 56  556 67  HOH HOH A . 
E 3 HOH 57  557 5   HOH HOH A . 
E 3 HOH 58  558 47  HOH HOH A . 
E 3 HOH 59  559 130 HOH HOH A . 
E 3 HOH 60  560 162 HOH HOH A . 
E 3 HOH 61  561 53  HOH HOH A . 
E 3 HOH 62  562 35  HOH HOH A . 
E 3 HOH 63  563 123 HOH HOH A . 
E 3 HOH 64  564 158 HOH HOH A . 
E 3 HOH 65  565 52  HOH HOH A . 
E 3 HOH 66  566 13  HOH HOH A . 
E 3 HOH 67  567 127 HOH HOH A . 
E 3 HOH 68  568 59  HOH HOH A . 
E 3 HOH 69  569 132 HOH HOH A . 
E 3 HOH 70  570 4   HOH HOH A . 
E 3 HOH 71  571 15  HOH HOH A . 
E 3 HOH 72  572 19  HOH HOH A . 
E 3 HOH 73  573 57  HOH HOH A . 
E 3 HOH 74  574 17  HOH HOH A . 
E 3 HOH 75  575 76  HOH HOH A . 
E 3 HOH 76  576 86  HOH HOH A . 
E 3 HOH 77  577 20  HOH HOH A . 
E 3 HOH 78  578 73  HOH HOH A . 
E 3 HOH 79  579 139 HOH HOH A . 
E 3 HOH 80  580 51  HOH HOH A . 
E 3 HOH 81  581 68  HOH HOH A . 
E 3 HOH 82  582 112 HOH HOH A . 
E 3 HOH 83  583 37  HOH HOH A . 
E 3 HOH 84  584 168 HOH HOH A . 
E 3 HOH 85  585 164 HOH HOH A . 
E 3 HOH 86  586 36  HOH HOH A . 
E 3 HOH 87  587 46  HOH HOH A . 
E 3 HOH 88  588 141 HOH HOH A . 
E 3 HOH 89  589 171 HOH HOH A . 
E 3 HOH 90  590 166 HOH HOH A . 
E 3 HOH 91  591 102 HOH HOH A . 
E 3 HOH 92  592 151 HOH HOH A . 
E 3 HOH 93  593 169 HOH HOH A . 
E 3 HOH 94  594 131 HOH HOH A . 
E 3 HOH 95  595 146 HOH HOH A . 
E 3 HOH 96  596 170 HOH HOH A . 
E 3 HOH 97  597 22  HOH HOH A . 
E 3 HOH 98  598 99  HOH HOH A . 
E 3 HOH 99  599 160 HOH HOH A . 
E 3 HOH 100 600 128 HOH HOH A . 
E 3 HOH 101 601 167 HOH HOH A . 
F 3 HOH 1   501 150 HOH HOH B . 
F 3 HOH 2   502 80  HOH HOH B . 
F 3 HOH 3   503 30  HOH HOH B . 
F 3 HOH 4   504 119 HOH HOH B . 
F 3 HOH 5   505 56  HOH HOH B . 
F 3 HOH 6   506 32  HOH HOH B . 
F 3 HOH 7   507 49  HOH HOH B . 
F 3 HOH 8   508 45  HOH HOH B . 
F 3 HOH 9   509 54  HOH HOH B . 
F 3 HOH 10  510 64  HOH HOH B . 
F 3 HOH 11  511 91  HOH HOH B . 
F 3 HOH 12  512 3   HOH HOH B . 
F 3 HOH 13  513 55  HOH HOH B . 
F 3 HOH 14  514 93  HOH HOH B . 
F 3 HOH 15  515 31  HOH HOH B . 
F 3 HOH 16  516 26  HOH HOH B . 
F 3 HOH 17  517 121 HOH HOH B . 
F 3 HOH 18  518 114 HOH HOH B . 
F 3 HOH 19  519 42  HOH HOH B . 
F 3 HOH 20  520 74  HOH HOH B . 
F 3 HOH 21  521 106 HOH HOH B . 
F 3 HOH 22  522 147 HOH HOH B . 
F 3 HOH 23  523 81  HOH HOH B . 
F 3 HOH 24  524 62  HOH HOH B . 
F 3 HOH 25  525 140 HOH HOH B . 
F 3 HOH 26  526 2   HOH HOH B . 
F 3 HOH 27  527 134 HOH HOH B . 
F 3 HOH 28  528 113 HOH HOH B . 
F 3 HOH 29  529 107 HOH HOH B . 
F 3 HOH 30  530 41  HOH HOH B . 
F 3 HOH 31  531 38  HOH HOH B . 
F 3 HOH 32  532 103 HOH HOH B . 
F 3 HOH 33  533 148 HOH HOH B . 
F 3 HOH 34  534 157 HOH HOH B . 
F 3 HOH 35  535 82  HOH HOH B . 
F 3 HOH 36  536 87  HOH HOH B . 
F 3 HOH 37  537 108 HOH HOH B . 
F 3 HOH 38  538 117 HOH HOH B . 
F 3 HOH 39  539 28  HOH HOH B . 
F 3 HOH 40  540 135 HOH HOH B . 
F 3 HOH 41  541 23  HOH HOH B . 
F 3 HOH 42  542 155 HOH HOH B . 
F 3 HOH 43  543 79  HOH HOH B . 
F 3 HOH 44  544 66  HOH HOH B . 
F 3 HOH 45  545 96  HOH HOH B . 
F 3 HOH 46  546 8   HOH HOH B . 
F 3 HOH 47  547 48  HOH HOH B . 
F 3 HOH 48  548 90  HOH HOH B . 
F 3 HOH 49  549 43  HOH HOH B . 
F 3 HOH 50  550 60  HOH HOH B . 
F 3 HOH 51  551 152 HOH HOH B . 
F 3 HOH 52  552 70  HOH HOH B . 
F 3 HOH 53  553 39  HOH HOH B . 
F 3 HOH 54  554 94  HOH HOH B . 
F 3 HOH 55  555 16  HOH HOH B . 
F 3 HOH 56  556 85  HOH HOH B . 
F 3 HOH 57  557 34  HOH HOH B . 
F 3 HOH 58  558 110 HOH HOH B . 
F 3 HOH 59  559 126 HOH HOH B . 
F 3 HOH 60  560 144 HOH HOH B . 
F 3 HOH 61  561 65  HOH HOH B . 
F 3 HOH 62  562 33  HOH HOH B . 
F 3 HOH 63  563 142 HOH HOH B . 
F 3 HOH 64  564 104 HOH HOH B . 
F 3 HOH 65  565 124 HOH HOH B . 
F 3 HOH 66  566 159 HOH HOH B . 
F 3 HOH 67  567 133 HOH HOH B . 
F 3 HOH 68  568 115 HOH HOH B . 
F 3 HOH 69  569 161 HOH HOH B . 
F 3 HOH 70  570 129 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASN 72  ? CG  ? A ASN 70  CG  
2  1 Y 1 A ASN 72  ? OD1 ? A ASN 70  OD1 
3  1 Y 1 A ASN 72  ? ND2 ? A ASN 70  ND2 
4  1 Y 1 A GLN 74  ? CG  ? A GLN 72  CG  
5  1 Y 1 A GLN 74  ? CD  ? A GLN 72  CD  
6  1 Y 1 A GLN 74  ? OE1 ? A GLN 72  OE1 
7  1 Y 1 A GLN 74  ? NE2 ? A GLN 72  NE2 
8  1 Y 1 A ARG 76  ? CG  ? A ARG 74  CG  
9  1 Y 1 A ARG 76  ? CD  ? A ARG 74  CD  
10 1 Y 1 A ARG 76  ? NE  ? A ARG 74  NE  
11 1 Y 1 A ARG 76  ? CZ  ? A ARG 74  CZ  
12 1 Y 1 A ARG 76  ? NH1 ? A ARG 74  NH1 
13 1 Y 1 A ARG 76  ? NH2 ? A ARG 74  NH2 
14 1 Y 1 A VAL 77  ? CG1 ? A VAL 75  CG1 
15 1 Y 1 A VAL 77  ? CG2 ? A VAL 75  CG2 
16 1 Y 1 A LYS 100 ? CG  ? A LYS 98  CG  
17 1 Y 1 A LYS 100 ? CD  ? A LYS 98  CD  
18 1 Y 1 A LYS 100 ? CE  ? A LYS 98  CE  
19 1 Y 1 A LYS 100 ? NZ  ? A LYS 98  NZ  
20 1 Y 1 A LYS 137 ? CG  ? A LYS 135 CG  
21 1 Y 1 A LYS 137 ? CD  ? A LYS 135 CD  
22 1 Y 1 A LYS 137 ? CE  ? A LYS 135 CE  
23 1 Y 1 A LYS 137 ? NZ  ? A LYS 135 NZ  
24 1 Y 1 A TYR 154 ? CG  ? A TYR 152 CG  
25 1 Y 1 A TYR 154 ? CD1 ? A TYR 152 CD1 
26 1 Y 1 A TYR 154 ? CD2 ? A TYR 152 CD2 
27 1 Y 1 A TYR 154 ? CE1 ? A TYR 152 CE1 
28 1 Y 1 A TYR 154 ? CE2 ? A TYR 152 CE2 
29 1 Y 1 A TYR 154 ? CZ  ? A TYR 152 CZ  
30 1 Y 1 A TYR 154 ? OH  ? A TYR 152 OH  
31 1 Y 1 A ARG 298 ? CG  ? A ARG 296 CG  
32 1 Y 1 A ARG 298 ? CD  ? A ARG 296 CD  
33 1 Y 1 A ARG 298 ? NE  ? A ARG 296 NE  
34 1 Y 1 A ARG 298 ? CZ  ? A ARG 296 CZ  
35 1 Y 1 A ARG 298 ? NH1 ? A ARG 296 NH1 
36 1 Y 1 A ARG 298 ? NH2 ? A ARG 296 NH2 
37 1 Y 1 B ARG 60  ? CG  ? B ARG 58  CG  
38 1 Y 1 B ARG 60  ? CD  ? B ARG 58  CD  
39 1 Y 1 B ARG 60  ? NE  ? B ARG 58  NE  
40 1 Y 1 B ARG 60  ? CZ  ? B ARG 58  CZ  
41 1 Y 1 B ARG 60  ? NH1 ? B ARG 58  NH1 
42 1 Y 1 B ARG 60  ? NH2 ? B ARG 58  NH2 
43 1 Y 1 B ASN 72  ? CG  ? B ASN 70  CG  
44 1 Y 1 B ASN 72  ? OD1 ? B ASN 70  OD1 
45 1 Y 1 B ASN 72  ? ND2 ? B ASN 70  ND2 
46 1 Y 1 B GLN 74  ? CG  ? B GLN 72  CG  
47 1 Y 1 B GLN 74  ? CD  ? B GLN 72  CD  
48 1 Y 1 B GLN 74  ? OE1 ? B GLN 72  OE1 
49 1 Y 1 B GLN 74  ? NE2 ? B GLN 72  NE2 
50 1 Y 1 B ARG 76  ? CG  ? B ARG 74  CG  
51 1 Y 1 B ARG 76  ? CD  ? B ARG 74  CD  
52 1 Y 1 B ARG 76  ? NE  ? B ARG 74  NE  
53 1 Y 1 B ARG 76  ? CZ  ? B ARG 74  CZ  
54 1 Y 1 B ARG 76  ? NH1 ? B ARG 74  NH1 
55 1 Y 1 B ARG 76  ? NH2 ? B ARG 74  NH2 
56 1 Y 1 B LYS 100 ? CG  ? B LYS 98  CG  
57 1 Y 1 B LYS 100 ? CD  ? B LYS 98  CD  
58 1 Y 1 B LYS 100 ? CE  ? B LYS 98  CE  
59 1 Y 1 B LYS 100 ? NZ  ? B LYS 98  NZ  
60 1 Y 1 B LYS 137 ? CG  ? B LYS 135 CG  
61 1 Y 1 B LYS 137 ? CD  ? B LYS 135 CD  
62 1 Y 1 B LYS 137 ? CE  ? B LYS 135 CE  
63 1 Y 1 B LYS 137 ? NZ  ? B LYS 135 NZ  
64 1 Y 1 B TYR 154 ? CG  ? B TYR 152 CG  
65 1 Y 1 B TYR 154 ? CD1 ? B TYR 152 CD1 
66 1 Y 1 B TYR 154 ? CD2 ? B TYR 152 CD2 
67 1 Y 1 B TYR 154 ? CE1 ? B TYR 152 CE1 
68 1 Y 1 B TYR 154 ? CE2 ? B TYR 152 CE2 
69 1 Y 1 B TYR 154 ? CZ  ? B TYR 152 CZ  
70 1 Y 1 B TYR 154 ? OH  ? B TYR 152 OH  
71 1 Y 1 B GLU 166 ? CG  ? B GLU 164 CG  
72 1 Y 1 B GLU 166 ? CD  ? B GLU 164 CD  
73 1 Y 1 B GLU 166 ? OE1 ? B GLU 164 OE1 
74 1 Y 1 B GLU 166 ? OE2 ? B GLU 164 OE2 
75 1 Y 1 B GLN 189 ? CG  ? B GLN 187 CG  
76 1 Y 1 B GLN 189 ? CD  ? B GLN 187 CD  
77 1 Y 1 B GLN 189 ? OE1 ? B GLN 187 OE1 
78 1 Y 1 B GLN 189 ? NE2 ? B GLN 187 NE2 
79 1 Y 1 B ARG 298 ? CG  ? B ARG 296 CG  
80 1 Y 1 B ARG 298 ? CD  ? B ARG 296 CD  
81 1 Y 1 B ARG 298 ? NE  ? B ARG 296 NE  
82 1 Y 1 B ARG 298 ? CZ  ? B ARG 296 CZ  
83 1 Y 1 B ARG 298 ? NH1 ? B ARG 296 NH1 
84 1 Y 1 B ARG 298 ? NH2 ? B ARG 296 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.12_2829 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YKO 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     68.210 
_cell.length_a_esd                 ? 
_cell.length_b                     101.487 
_cell.length_b_esd                 ? 
_cell.length_c                     104.585 
_cell.length_c_esd                 ? 
_cell.volume                       723982.161 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YKO 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YKO 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.75 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.20 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BICINE pH 8.5, 20% w/v Polyethylene glycol 10,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          -4.6919909978 
_reflns.entry_id                                       8YKO 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.11 
_reflns.d_resolution_low                               72.83 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40212 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           94.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                8.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.128 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.11 
_reflns_shell.d_res_low                                     2.22 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6116 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.008 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               14.4999277338 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YKO 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.11 
_refine.ls_d_res_low                             72.83 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39932 
_refine.ls_number_reflns_R_free                  1928 
_refine.ls_number_reflns_R_work                  38004 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    93.5570029521 
_refine.ls_percent_reflns_R_free                 4.82820795352 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.231721466098 
_refine.ls_R_factor_R_free                       0.27893534137 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.229326203782 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.32727119706 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.6401913101 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.279254855076 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.11 
_refine_hist.d_res_low                        72.83 
_refine_hist.number_atoms_solvent             171 
_refine_hist.number_atoms_total               4727 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4488 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         68 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00734403213208 ? 4663 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.999372553887   ? 6354 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0550750252398  ? 722  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00649298654239 ? 820  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.49050375778    ? 2700 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.11   2.1596 . . 137 2738 95.9612817089 . . . . 0.259461422533 . . . . . . . . . . . 0.29417277894  
'X-RAY DIFFRACTION' 2.1596 2.218  . . 142 2802 97.9048885933 . . . . 0.252980973459 . . . . . . . . . . . 0.299856642053 
'X-RAY DIFFRACTION' 2.218  2.2833 . . 65  1145 40.2394413036 . . . . 0.270290352345 . . . . . . . . . . . 0.320730753735 
'X-RAY DIFFRACTION' 2.2833 2.357  . . 127 2867 98.8445031363 . . . . 0.251849615027 . . . . . . . . . . . 0.296005652375 
'X-RAY DIFFRACTION' 2.357  2.4412 . . 112 2870 99.0039840637 . . . . 0.248886754297 . . . . . . . . . . . 0.327155356858 
'X-RAY DIFFRACTION' 2.4412 2.539  . . 156 2805 98.5357737105 . . . . 0.248950399392 . . . . . . . . . . . 0.305271458874 
'X-RAY DIFFRACTION' 2.539  2.6545 . . 154 2830 99.0703851262 . . . . 0.247007518705 . . . . . . . . . . . 0.307747293744 
'X-RAY DIFFRACTION' 2.6545 2.7945 . . 175 2798 98.6396814864 . . . . 0.247666538517 . . . . . . . . . . . 0.324037977468 
'X-RAY DIFFRACTION' 2.7945 2.9696 . . 149 2863 98.2707993475 . . . . 0.244729646159 . . . . . . . . . . . 0.292346561961 
'X-RAY DIFFRACTION' 2.9696 3.1989 . . 159 2803 97.8849966953 . . . . 0.236594765297 . . . . . . . . . . . 0.258172994568 
'X-RAY DIFFRACTION' 3.1989 3.5208 . . 135 2858 97.8744277305 . . . . 0.22899409335  . . . . . . . . . . . 0.313302142974 
'X-RAY DIFFRACTION' 3.5208 4.0302 . . 160 2844 97.3428386261 . . . . 0.191963802442 . . . . . . . . . . . 0.235826468874 
'X-RAY DIFFRACTION' 4.0302 5.0774 . . 130 2858 96.3249516441 . . . . 0.160308528903 . . . . . . . . . . . 0.182294650996 
'X-RAY DIFFRACTION' 5.0774 72.83  . . 127 2923 93.5869898742 . . . . 0.184066618937 . . . . . . . . . . . 0.20621748294  
# 
_struct.entry_id                     8YKO 
_struct.title                        'Crystal structure of SARS-Cov-2 main protease P132H mutant in complex withX77' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YKO 
_struct_keywords.text            'VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
;
_struct_ref.pdbx_align_begin           3266 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YKO A 1 ? 298 ? P0DTD1 3266 ? 3563 ? 3 300 
2 1 8YKO B 1 ? 298 ? P0DTD1 3266 ? 3563 ? 3 300 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YKO HIS A 130 ? UNP P0DTD1 PRO 3395 'engineered mutation' 132 1 
2 8YKO HIS B 130 ? UNP P0DTD1 PRO 3395 'engineered mutation' 132 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2070  ? 
1 MORE         -12   ? 
1 'SSA (A^2)'  24930 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 8   ? GLY A 13  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 39  ? CYS A 42  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 51  ? ARG A 58  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4  AA4 SER A 60  ? HIS A 62  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P5  AA5 ILE A 198 ? ASN A 212 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 224 ? LYS A 234 ? THR A 226 LYS A 236 1 ? 11 
HELX_P HELX_P7  AA7 THR A 241 ? LEU A 248 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P8  AA8 LEU A 248 ? GLY A 256 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P9  AA9 ALA A 258 ? GLY A 273 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 290 ? CYS A 298 ? THR A 292 CYS A 300 1 ? 9  
HELX_P HELX_P11 AB2 SER B 8   ? GLY B 13  ? SER B 10  GLY B 15  1 ? 6  
HELX_P HELX_P12 AB3 HIS B 39  ? CYS B 42  ? HIS B 41  CYS B 44  5 ? 4  
HELX_P HELX_P13 AB4 THR B 43  ? MET B 47  ? THR B 45  MET B 49  5 ? 5  
HELX_P HELX_P14 AB5 ASN B 51  ? ARG B 58  ? ASN B 53  ARG B 60  1 ? 8  
HELX_P HELX_P15 AB6 SER B 60  ? PHE B 64  ? SER B 62  PHE B 66  5 ? 5  
HELX_P HELX_P16 AB7 ILE B 198 ? ASN B 212 ? ILE B 200 ASN B 214 1 ? 15 
HELX_P HELX_P17 AB8 THR B 224 ? TYR B 235 ? THR B 226 TYR B 237 1 ? 12 
HELX_P HELX_P18 AB9 THR B 241 ? LEU B 248 ? THR B 243 LEU B 250 1 ? 8  
HELX_P HELX_P19 AC1 LEU B 248 ? GLY B 256 ? LEU B 250 GLY B 258 1 ? 9  
HELX_P HELX_P20 AC2 ALA B 258 ? LEU B 269 ? ALA B 260 LEU B 271 1 ? 12 
HELX_P HELX_P21 AC3 THR B 290 ? ARG B 296 ? THR B 292 ARG B 298 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 71  ? LEU A 73  ? VAL A 73  LEU A 75  
AA1 2 PHE A 64  ? ALA A 68  ? PHE A 66  ALA A 70  
AA1 3 MET A 15  ? CYS A 20  ? MET A 17  CYS A 22  
AA1 4 THR A 23  ? LEU A 30  ? THR A 25  LEU A 32  
AA1 5 VAL A 33  ? PRO A 37  ? VAL A 35  PRO A 39  
AA1 6 VAL A 84  ? VAL A 89  ? VAL A 86  VAL A 91  
AA1 7 VAL A 75  ? GLN A 81  ? VAL A 77  GLN A 83  
AA2 1 TYR A 99  ? PHE A 101 ? TYR A 101 PHE A 103 
AA2 2 CYS A 154 ? GLU A 164 ? CYS A 156 GLU A 166 
AA2 3 VAL A 146 ? ASP A 151 ? VAL A 148 ASP A 153 
AA2 4 THR A 109 ? TYR A 116 ? THR A 111 TYR A 118 
AA2 5 SER A 119 ? ALA A 127 ? SER A 121 ALA A 129 
AA3 1 TYR A 99  ? PHE A 101 ? TYR A 101 PHE A 103 
AA3 2 CYS A 154 ? GLU A 164 ? CYS A 156 GLU A 166 
AA3 3 HIS A 170 ? THR A 173 ? HIS A 172 THR A 175 
AA4 1 VAL B 71  ? LEU B 73  ? VAL B 73  LEU B 75  
AA4 2 LEU B 65  ? ALA B 68  ? LEU B 67  ALA B 70  
AA4 3 MET B 15  ? CYS B 20  ? MET B 17  CYS B 22  
AA4 4 THR B 23  ? LEU B 30  ? THR B 25  LEU B 32  
AA4 5 VAL B 33  ? PRO B 37  ? VAL B 35  PRO B 39  
AA4 6 VAL B 84  ? VAL B 89  ? VAL B 86  VAL B 91  
AA4 7 VAL B 75  ? GLN B 81  ? VAL B 77  GLN B 83  
AA5 1 LYS B 98  ? PHE B 101 ? LYS B 100 PHE B 103 
AA5 2 CYS B 154 ? GLU B 164 ? CYS B 156 GLU B 166 
AA5 3 VAL B 146 ? ASP B 151 ? VAL B 148 ASP B 153 
AA5 4 THR B 109 ? TYR B 116 ? THR B 111 TYR B 118 
AA5 5 SER B 119 ? ALA B 127 ? SER B 121 ALA B 129 
AA6 1 LYS B 98  ? PHE B 101 ? LYS B 100 PHE B 103 
AA6 2 CYS B 154 ? GLU B 164 ? CYS B 156 GLU B 166 
AA6 3 HIS B 170 ? THR B 173 ? HIS B 172 THR B 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 71  ? O VAL A 73  N ALA A 68  ? N ALA A 70  
AA1 2 3 O LEU A 65  ? O LEU A 67  N THR A 19  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 20  O LEU A 25  ? O LEU A 27  
AA1 4 5 N LEU A 28  ? N LEU A 30  O TYR A 35  ? O TYR A 37  
AA1 5 6 N VAL A 34  ? N VAL A 36  O LEU A 87  ? O LEU A 89  
AA1 6 7 O LYS A 86  ? O LYS A 88  N SER A 79  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 102 O PHE A 157 ? O PHE A 159 
AA2 2 3 O SER A 156 ? O SER A 158 N ASN A 149 ? N ASN A 151 
AA2 3 4 O PHE A 148 ? O PHE A 150 N SER A 111 ? N SER A 113 
AA2 4 5 N ALA A 114 ? N ALA A 116 O SER A 121 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 102 O PHE A 157 ? O PHE A 159 
AA3 2 3 N MET A 163 ? N MET A 165 O ALA A 171 ? O ALA A 173 
AA4 1 2 O LEU B 73  ? O LEU B 75  N VAL B 66  ? N VAL B 68  
AA4 2 3 O LEU B 65  ? O LEU B 67  N THR B 19  ? N THR B 21  
AA4 3 4 N VAL B 18  ? N VAL B 20  O LEU B 25  ? O LEU B 27  
AA4 4 5 N LEU B 28  ? N LEU B 30  O TYR B 35  ? O TYR B 37  
AA4 5 6 N CYS B 36  ? N CYS B 38  O LEU B 85  ? O LEU B 87  
AA4 6 7 O LYS B 86  ? O LYS B 88  N SER B 79  ? N SER B 81  
AA5 1 2 N LYS B 98  ? N LYS B 100 O VAL B 155 ? O VAL B 157 
AA5 2 3 O SER B 156 ? O SER B 158 N ASN B 149 ? N ASN B 151 
AA5 3 4 O PHE B 148 ? O PHE B 150 N SER B 111 ? N SER B 113 
AA5 4 5 N PHE B 110 ? N PHE B 112 O CYS B 126 ? O CYS B 128 
AA6 1 2 N LYS B 98  ? N LYS B 100 O VAL B 155 ? O VAL B 157 
AA6 2 3 N MET B 163 ? N MET B 165 O ALA B 171 ? O ALA B 173 
# 
_pdbx_entry_details.entry_id                   8YKO 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 33  ? ? 53.00   -129.05 
2  1 ASN A 84  ? ? 54.54   -119.52 
3  1 ASP A 155 ? ? 56.01   13.30   
4  1 ASN A 214 ? ? -74.95  -138.07 
5  1 ASP B 33  ? ? 49.10   -125.67 
6  1 ASN B 51  ? ? -151.70 71.45   
7  1 ASN B 84  ? ? 50.99   -123.41 
8  1 TYR B 154 ? ? 43.44   76.11   
9  1 ASN B 214 ? ? -87.72  -140.69 
10 1 LEU B 282 ? ? -146.69 54.49   
11 1 ARG B 298 ? ? -59.85  172.10  
12 1 GLN B 299 ? ? 63.91   -42.96  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       570 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.76 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 B LEU 272 ? B LEU 270 
2 1 Y 1 B GLN 273 ? B GLN 271 
3 1 Y 1 B ASN 274 ? B ASN 272 
4 1 Y 1 B GLY 275 ? B GLY 273 
5 1 Y 1 B MET 276 ? B MET 274 
6 1 Y 1 B ASN 277 ? B ASN 275 
7 1 Y 1 B GLY 278 ? B GLY 276 
8 1 Y 1 B ARG 279 ? B ARG 277 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
X77 C02  C N N 391 
X77 C04  C N R 392 
X77 C05  C N N 393 
X77 C07  C N N 394 
X77 C08  C N N 395 
X77 C09  C N N 396 
X77 C10  C N N 397 
X77 C11  C N N 398 
X77 C12  C N N 399 
X77 C14  C Y N 400 
X77 C15  C Y N 401 
X77 C16  C Y N 402 
X77 C17  C Y N 403 
X77 C19  C Y N 404 
X77 C20  C Y N 405 
X77 C21  C Y N 406 
X77 C22  C Y N 407 
X77 C23  C Y N 408 
X77 C24  C N N 409 
X77 C25  C N N 410 
X77 C26  C N N 411 
X77 C27  C N N 412 
X77 C28  C Y N 413 
X77 C29  C Y N 414 
X77 C30  C Y N 415 
X77 C31  C Y N 416 
X77 C33  C Y N 417 
X77 N03  N N N 418 
X77 N06  N N N 419 
X77 N18  N Y N 420 
X77 N32  N Y N 421 
X77 N34  N Y N 422 
X77 O01  O N N 423 
X77 O13  O N N 424 
X77 H041 H N N 425 
X77 H071 H N N 426 
X77 H081 H N N 427 
X77 H082 H N N 428 
X77 H091 H N N 429 
X77 H092 H N N 430 
X77 H101 H N N 431 
X77 H102 H N N 432 
X77 H112 H N N 433 
X77 H111 H N N 434 
X77 H121 H N N 435 
X77 H122 H N N 436 
X77 H151 H N N 437 
X77 H161 H N N 438 
X77 H171 H N N 439 
X77 H191 H N N 440 
X77 H211 H N N 441 
X77 H221 H N N 442 
X77 H251 H N N 443 
X77 H252 H N N 444 
X77 H253 H N N 445 
X77 H261 H N N 446 
X77 H263 H N N 447 
X77 H262 H N N 448 
X77 H272 H N N 449 
X77 H273 H N N 450 
X77 H271 H N N 451 
X77 H281 H N N 452 
X77 H291 H N N 453 
X77 H311 H N N 454 
X77 H331 H N N 455 
X77 H061 H N N 456 
X77 H1   H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
X77 C33 N32  sing Y N 376 
X77 C33 N34  doub Y N 377 
X77 N32 C31  sing Y N 378 
X77 N34 C30  sing Y N 379 
X77 C31 C30  doub Y N 380 
X77 C30 C02  sing N N 381 
X77 C27 C24  sing N N 382 
X77 C02 O01  doub N N 383 
X77 C02 N03  sing N N 384 
X77 C26 C24  sing N N 385 
X77 C28 C29  doub Y N 386 
X77 C28 C23  sing Y N 387 
X77 C24 C23  sing N N 388 
X77 C24 C25  sing N N 389 
X77 C29 C20  sing Y N 390 
X77 C23 C22  doub Y N 391 
X77 C20 N03  sing N N 392 
X77 C20 C21  doub Y N 393 
X77 C22 C21  sing Y N 394 
X77 N03 C04  sing N N 395 
X77 C19 N18  doub Y N 396 
X77 C19 C14  sing Y N 397 
X77 C04 C14  sing N N 398 
X77 C04 C05  sing N N 399 
X77 N18 C17  sing Y N 400 
X77 C14 C15  doub Y N 401 
X77 O13 C05  doub N N 402 
X77 C17 C16  doub Y N 403 
X77 C05 N06  sing N N 404 
X77 C15 C16  sing Y N 405 
X77 N06 C07  sing N N 406 
X77 C12 C07  sing N N 407 
X77 C12 C11  sing N N 408 
X77 C07 C08  sing N N 409 
X77 C11 C10  sing N N 410 
X77 C08 C09  sing N N 411 
X77 C10 C09  sing N N 412 
X77 C04 H041 sing N N 413 
X77 C07 H071 sing N N 414 
X77 C08 H081 sing N N 415 
X77 C08 H082 sing N N 416 
X77 C09 H091 sing N N 417 
X77 C09 H092 sing N N 418 
X77 C10 H101 sing N N 419 
X77 C10 H102 sing N N 420 
X77 C11 H112 sing N N 421 
X77 C11 H111 sing N N 422 
X77 C12 H121 sing N N 423 
X77 C12 H122 sing N N 424 
X77 C15 H151 sing N N 425 
X77 C16 H161 sing N N 426 
X77 C17 H171 sing N N 427 
X77 C19 H191 sing N N 428 
X77 C21 H211 sing N N 429 
X77 C22 H221 sing N N 430 
X77 C25 H251 sing N N 431 
X77 C25 H252 sing N N 432 
X77 C25 H253 sing N N 433 
X77 C26 H261 sing N N 434 
X77 C26 H263 sing N N 435 
X77 C26 H262 sing N N 436 
X77 C27 H272 sing N N 437 
X77 C27 H273 sing N N 438 
X77 C27 H271 sing N N 439 
X77 C28 H281 sing N N 440 
X77 C29 H291 sing N N 441 
X77 C31 H311 sing N N 442 
X77 C33 H331 sing N N 443 
X77 N06 H061 sing N N 444 
X77 N32 H1   sing N N 445 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7C2Q 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YKO 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014661 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009853 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009562 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 1   ? 10.41598  4.79327   -17.10546 1.000 29.09210 ? 3   PHE A N   1 
ATOM   2    C CA  . PHE A 1 1   ? 9.30253   5.30382   -17.91535 1.000 38.64949 ? 3   PHE A CA  1 
ATOM   3    C C   . PHE A 1 1   ? 8.08588   4.37790   -17.96203 1.000 32.49707 ? 3   PHE A C   1 
ATOM   4    O O   . PHE A 1 1   ? 8.16856   3.22324   -18.37979 1.000 32.77860 ? 3   PHE A O   1 
ATOM   5    C CB  . PHE A 1 1   ? 9.75286   5.58253   -19.35033 1.000 29.64823 ? 3   PHE A CB  1 
ATOM   6    C CG  . PHE A 1 1   ? 9.85043   7.04202   -19.67701 1.000 27.61416 ? 3   PHE A CG  1 
ATOM   7    C CD1 . PHE A 1 1   ? 10.78954  7.84056   -19.04328 1.000 43.83309 ? 3   PHE A CD1 1 
ATOM   8    C CD2 . PHE A 1 1   ? 9.00535   7.61581   -20.61730 1.000 28.44272 ? 3   PHE A CD2 1 
ATOM   9    C CE1 . PHE A 1 1   ? 10.89919  9.18480   -19.34391 1.000 47.08021 ? 3   PHE A CE1 1 
ATOM   10   C CE2 . PHE A 1 1   ? 9.10132   8.95867   -20.92119 1.000 31.35244 ? 3   PHE A CE2 1 
ATOM   11   C CZ  . PHE A 1 1   ? 10.05226  9.74661   -20.28394 1.000 41.89636 ? 3   PHE A CZ  1 
ATOM   12   N N   . ARG A 1 2   ? 6.94802   4.90908   -17.54463 1.000 23.35524 ? 4   ARG A N   1 
ATOM   13   C CA  . ARG A 1 2   ? 5.70729   4.16333   -17.51726 1.000 22.09661 ? 4   ARG A CA  1 
ATOM   14   C C   . ARG A 1 2   ? 4.70339   4.83066   -18.44832 1.000 16.73408 ? 4   ARG A C   1 
ATOM   15   O O   . ARG A 1 2   ? 4.72701   6.04843   -18.64933 1.000 12.92830 ? 4   ARG A O   1 
ATOM   16   C CB  . ARG A 1 2   ? 5.12358   4.10115   -16.09490 1.000 19.86120 ? 4   ARG A CB  1 
ATOM   17   C CG  . ARG A 1 2   ? 5.90358   3.27171   -15.08998 1.000 18.89166 ? 4   ARG A CG  1 
ATOM   18   C CD  . ARG A 1 2   ? 5.27344   1.89486   -14.91614 1.000 21.63407 ? 4   ARG A CD  1 
ATOM   19   N NE  . ARG A 1 2   ? 5.96760   1.08715   -13.92302 1.000 20.51002 ? 4   ARG A NE  1 
ATOM   20   C CZ  . ARG A 1 2   ? 5.82177   -0.22726  -13.80166 1.000 24.43864 ? 4   ARG A CZ  1 
ATOM   21   N NH1 . ARG A 1 2   ? 5.01263   -0.87196  -14.62810 1.000 32.03578 ? 4   ARG A NH1 1 
ATOM   22   N NH2 . ARG A 1 2   ? 6.48899   -0.90116  -12.86285 1.000 17.80690 ? 4   ARG A NH2 1 
ATOM   23   N N   . LYS A 1 3   ? 3.80781   4.03561   -19.00811 1.000 20.20410 ? 5   LYS A N   1 
ATOM   24   C CA  . LYS A 1 3   ? 2.59121   4.63456   -19.52422 1.000 23.99753 ? 5   LYS A CA  1 
ATOM   25   C C   . LYS A 1 3   ? 1.74337   5.04432   -18.32570 1.000 17.54638 ? 5   LYS A C   1 
ATOM   26   O O   . LYS A 1 3   ? 1.33070   4.20242   -17.52493 1.000 24.54171 ? 5   LYS A O   1 
ATOM   27   C CB  . LYS A 1 3   ? 1.84617   3.67724   -20.44184 1.000 23.41035 ? 5   LYS A CB  1 
ATOM   28   C CG  . LYS A 1 3   ? 1.10343   4.43178   -21.51430 1.000 25.06411 ? 5   LYS A CG  1 
ATOM   29   C CD  . LYS A 1 3   ? 0.80953   3.55175   -22.69593 1.000 27.02779 ? 5   LYS A CD  1 
ATOM   30   C CE  . LYS A 1 3   ? 2.03521   3.30248   -23.52563 1.000 19.65499 ? 5   LYS A CE  1 
ATOM   31   N NZ  . LYS A 1 3   ? 1.98028   1.89126   -23.98254 1.000 20.68569 ? 5   LYS A NZ  1 
ATOM   32   N N   . MET A 1 4   ? 1.53571   6.33885   -18.16405 1.000 14.47737 ? 6   MET A N   1 
ATOM   33   C CA  . MET A 1 4   ? 0.87251   6.88835   -16.99611 1.000 15.54537 ? 6   MET A CA  1 
ATOM   34   C C   . MET A 1 4   ? -0.48425  7.42042   -17.41867 1.000 10.68721 ? 6   MET A C   1 
ATOM   35   O O   . MET A 1 4   ? -0.59113  8.11185   -18.43278 1.000 9.13339  ? 6   MET A O   1 
ATOM   36   C CB  . MET A 1 4   ? 1.71335   8.00640   -16.39327 1.000 16.29767 ? 6   MET A CB  1 
ATOM   37   C CG  . MET A 1 4   ? 1.65437   8.13130   -14.89873 1.000 18.44739 ? 6   MET A CG  1 
ATOM   38   S SD  . MET A 1 4   ? 3.12329   9.04098   -14.38374 1.000 35.59765 ? 6   MET A SD  1 
ATOM   39   C CE  . MET A 1 4   ? 4.39749   8.01745   -15.09345 1.000 18.66429 ? 6   MET A CE  1 
ATOM   40   N N   . ALA A 1 5   ? -1.51059  7.09347   -16.65392 1.000 8.94254  ? 7   ALA A N   1 
ATOM   41   C CA  . ALA A 1 5   ? -2.83115  7.63806   -16.90521 1.000 8.42401  ? 7   ALA A CA  1 
ATOM   42   C C   . ALA A 1 5   ? -3.03793  8.89214   -16.06677 1.000 8.54992  ? 7   ALA A C   1 
ATOM   43   O O   . ALA A 1 5   ? -2.29515  9.16767   -15.11668 1.000 5.58215  ? 7   ALA A O   1 
ATOM   44   C CB  . ALA A 1 5   ? -3.90928  6.60024   -16.58716 1.000 5.41373  ? 7   ALA A CB  1 
ATOM   45   N N   . PHE A 1 6   ? -4.07970  9.64930   -16.40706 1.000 6.66800  ? 8   PHE A N   1 
ATOM   46   C CA  . PHE A 1 6   ? -4.38050  10.77272  -15.53703 1.000 6.34264  ? 8   PHE A CA  1 
ATOM   47   C C   . PHE A 1 6   ? -5.14446  10.28481  -14.30819 1.000 7.26132  ? 8   PHE A C   1 
ATOM   48   O O   . PHE A 1 6   ? -5.85798  9.27562   -14.37671 1.000 5.16455  ? 8   PHE A O   1 
ATOM   49   C CB  . PHE A 1 6   ? -5.19144  11.83106  -16.28208 1.000 6.79116  ? 8   PHE A CB  1 
ATOM   50   C CG  . PHE A 1 6   ? -4.36473  12.69553  -17.18881 1.000 9.47970  ? 8   PHE A CG  1 
ATOM   51   C CD1 . PHE A 1 6   ? -3.57028  13.71037  -16.67222 1.000 11.55894 ? 8   PHE A CD1 1 
ATOM   52   C CD2 . PHE A 1 6   ? -4.36744  12.48673  -18.55901 1.000 9.26070  ? 8   PHE A CD2 1 
ATOM   53   C CE1 . PHE A 1 6   ? -2.79014  14.49643  -17.50483 1.000 10.73467 ? 8   PHE A CE1 1 
ATOM   54   C CE2 . PHE A 1 6   ? -3.59943  13.28325  -19.39615 1.000 9.69801  ? 8   PHE A CE2 1 
ATOM   55   C CZ  . PHE A 1 6   ? -2.81028  14.28557  -18.86699 1.000 12.66614 ? 8   PHE A CZ  1 
ATOM   56   N N   . PRO A 1 7   ? -4.99282  10.96243  -13.16785 1.000 3.72796  ? 9   PRO A N   1 
ATOM   57   C CA  . PRO A 1 7   ? -5.79748  10.59884  -11.99383 1.000 4.32063  ? 9   PRO A CA  1 
ATOM   58   C C   . PRO A 1 7   ? -7.27369  10.67951  -12.35928 1.000 5.10819  ? 9   PRO A C   1 
ATOM   59   O O   . PRO A 1 7   ? -7.71593  11.65759  -12.95427 1.000 6.02025  ? 9   PRO A O   1 
ATOM   60   C CB  . PRO A 1 7   ? -5.41015  11.65281  -10.94378 1.000 3.42574  ? 9   PRO A CB  1 
ATOM   61   C CG  . PRO A 1 7   ? -4.12420  12.25890  -11.44660 1.000 6.55156  ? 9   PRO A CG  1 
ATOM   62   C CD  . PRO A 1 7   ? -4.24894  12.21084  -12.95153 1.000 4.86587  ? 9   PRO A CD  1 
ATOM   63   N N   . SER A 1 8   ? -8.02094  9.63063   -12.02973 1.000 1.56014  ? 10  SER A N   1 
ATOM   64   C CA  . SER A 1 8   ? -9.35288  9.41990   -12.58240 1.000 7.64530  ? 10  SER A CA  1 
ATOM   65   C C   . SER A 1 8   ? -10.47652 9.99148   -11.72377 1.000 4.45115  ? 10  SER A C   1 
ATOM   66   O O   . SER A 1 8   ? -11.64434 9.88759   -12.12522 1.000 8.35224  ? 10  SER A O   1 
ATOM   67   C CB  . SER A 1 8   ? -9.60199  7.92804   -12.78317 1.000 3.79345  ? 10  SER A CB  1 
ATOM   68   O OG  . SER A 1 8   ? -9.50288  7.25763   -11.53745 1.000 7.38046  ? 10  SER A OG  1 
ATOM   69   N N   . GLY A 1 9   ? -10.15125 10.60218  -10.57888 1.000 3.59711  ? 11  GLY A N   1 
ATOM   70   C CA  . GLY A 1 9   ? -11.17803 11.02578  -9.63623  1.000 6.59426  ? 11  GLY A CA  1 
ATOM   71   C C   . GLY A 1 9   ? -12.22722 11.94539  -10.23535 1.000 5.29036  ? 11  GLY A C   1 
ATOM   72   O O   . GLY A 1 9   ? -13.41259 11.82167  -9.93123  1.000 5.98255  ? 11  GLY A O   1 
ATOM   73   N N   . LYS A 1 10  ? -11.80189 12.89582  -11.06668 1.000 4.19403  ? 12  LYS A N   1 
ATOM   74   C CA  . LYS A 1 10  ? -12.73411 13.86824  -11.62917 1.000 6.85360  ? 12  LYS A CA  1 
ATOM   75   C C   . LYS A 1 10  ? -13.76384 13.20197  -12.53529 1.000 6.84233  ? 12  LYS A C   1 
ATOM   76   O O   . LYS A 1 10  ? -14.91746 13.64787  -12.59428 1.000 9.14684  ? 12  LYS A O   1 
ATOM   77   C CB  . LYS A 1 10  ? -11.96104 14.95199  -12.38428 1.000 4.41345  ? 12  LYS A CB  1 
ATOM   78   C CG  . LYS A 1 10  ? -11.18623 15.89496  -11.46137 1.000 9.10000  ? 12  LYS A CG  1 
ATOM   79   C CD  . LYS A 1 10  ? -10.43848 16.97978  -12.22873 1.000 10.89087 ? 12  LYS A CD  1 
ATOM   80   C CE  . LYS A 1 10  ? -9.89829  18.04102  -11.27232 1.000 18.54930 ? 12  LYS A CE  1 
ATOM   81   N NZ  . LYS A 1 10  ? -8.85940  17.48980  -10.35715 1.000 24.02909 ? 12  LYS A NZ  1 
ATOM   82   N N   . VAL A 1 11  ? -13.37844 12.11779  -13.21111 1.000 5.74656  ? 13  VAL A N   1 
ATOM   83   C CA  . VAL A 1 11  ? -14.29196 11.38226  -14.07978 1.000 6.33796  ? 13  VAL A CA  1 
ATOM   84   C C   . VAL A 1 11  ? -15.15181 10.40963  -13.27114 1.000 4.08208  ? 13  VAL A C   1 
ATOM   85   O O   . VAL A 1 11  ? -16.33064 10.21390  -13.59398 1.000 6.05082  ? 13  VAL A O   1 
ATOM   86   C CB  . VAL A 1 11  ? -13.48730 10.66662  -15.18701 1.000 4.26772  ? 13  VAL A CB  1 
ATOM   87   C CG1 . VAL A 1 11  ? -14.39005 9.88081   -16.12354 1.000 4.02554  ? 13  VAL A CG1 1 
ATOM   88   C CG2 . VAL A 1 11  ? -12.67984 11.66704  -15.97108 1.000 3.80738  ? 13  VAL A CG2 1 
ATOM   89   N N   . GLU A 1 12  ? -14.60060 9.81610   -12.19939 1.000 3.98176  ? 14  GLU A N   1 
ATOM   90   C CA  . GLU A 1 12  ? -15.35795 8.85912   -11.38280 1.000 6.09295  ? 14  GLU A CA  1 
ATOM   91   C C   . GLU A 1 12  ? -16.64824 9.47402   -10.83664 1.000 4.29836  ? 14  GLU A C   1 
ATOM   92   O O   . GLU A 1 12  ? -17.68191 8.80863   -10.79919 1.000 5.72447  ? 14  GLU A O   1 
ATOM   93   C CB  . GLU A 1 12  ? -14.51180 8.32975   -10.21259 1.000 4.23304  ? 14  GLU A CB  1 
ATOM   94   C CG  . GLU A 1 12  ? -13.24065 7.56984   -10.58526 1.000 5.23496  ? 14  GLU A CG  1 
ATOM   95   C CD  . GLU A 1 12  ? -12.28027 7.37004   -9.39633  1.000 4.79991  ? 14  GLU A CD  1 
ATOM   96   O OE1 . GLU A 1 12  ? -12.74127 7.00888   -8.30408  1.000 10.85803 ? 14  GLU A OE1 1 
ATOM   97   O OE2 . GLU A 1 12  ? -11.05819 7.55628   -9.55484  1.000 6.28427  ? 14  GLU A OE2 1 
ATOM   98   N N   . GLY A 1 13  ? -16.59367 10.73006  -10.37632 1.000 4.80570  ? 15  GLY A N   1 
ATOM   99   C CA  . GLY A 1 13  ? -17.73126 11.44529  -9.84258  1.000 6.61835  ? 15  GLY A CA  1 
ATOM   100  C C   . GLY A 1 13  ? -18.79637 11.78609  -10.86567 1.000 9.41309  ? 15  GLY A C   1 
ATOM   101  O O   . GLY A 1 13  ? -19.79162 12.43409  -10.52438 1.000 9.08888  ? 15  GLY A O   1 
ATOM   102  N N   . CYS A 1 14  ? -18.59872 11.35836  -12.11320 1.000 8.02845  ? 16  CYS A N   1 
ATOM   103  C CA  . CYS A 1 14  ? -19.52836 11.57352  -13.20686 1.000 5.57140  ? 16  CYS A CA  1 
ATOM   104  C C   . CYS A 1 14  ? -20.15584 10.30062  -13.74284 1.000 6.75531  ? 16  CYS A C   1 
ATOM   105  O O   . CYS A 1 14  ? -21.10406 10.39592  -14.53292 1.000 6.94728  ? 16  CYS A O   1 
ATOM   106  C CB  . CYS A 1 14  ? -18.82449 12.27233  -14.37890 1.000 5.58264  ? 16  CYS A CB  1 
ATOM   107  S SG  . CYS A 1 14  ? -18.17794 13.88519  -14.03771 1.000 11.71125 ? 16  CYS A SG  1 
ATOM   108  N N   . MET A 1 15  ? -19.64351 9.11994   -13.38516 1.000 6.33866  ? 17  MET A N   1 
ATOM   109  C CA  . MET A 1 15  ? -20.09793 7.88874   -14.02268 1.000 6.13155  ? 17  MET A CA  1 
ATOM   110  C C   . MET A 1 15  ? -21.40874 7.42932   -13.39681 1.000 7.51314  ? 17  MET A C   1 
ATOM   111  O O   . MET A 1 15  ? -21.52881 7.37065   -12.17149 1.000 7.81902  ? 17  MET A O   1 
ATOM   112  C CB  . MET A 1 15  ? -19.04349 6.78846   -13.90882 1.000 7.67399  ? 17  MET A CB  1 
ATOM   113  C CG  . MET A 1 15  ? -17.71155 7.11249   -14.60340 1.000 7.07490  ? 17  MET A CG  1 
ATOM   114  S SD  . MET A 1 15  ? -17.94232 7.62865   -16.32278 1.000 6.37156  ? 17  MET A SD  1 
ATOM   115  C CE  . MET A 1 15  ? -18.77758 6.18358   -16.98809 1.000 4.61215  ? 17  MET A CE  1 
ATOM   116  N N   . VAL A 1 16  ? -22.39672 7.12026   -14.23729 1.000 7.83857  ? 18  VAL A N   1 
ATOM   117  C CA  . VAL A 1 16  ? -23.67941 6.59682   -13.77563 1.000 6.76601  ? 18  VAL A CA  1 
ATOM   118  C C   . VAL A 1 16  ? -24.04059 5.35923   -14.57972 1.000 6.90130  ? 18  VAL A C   1 
ATOM   119  O O   . VAL A 1 16  ? -23.38755 4.99741   -15.56785 1.000 6.28993  ? 18  VAL A O   1 
ATOM   120  C CB  . VAL A 1 16  ? -24.83334 7.62292   -13.86614 1.000 7.02466  ? 18  VAL A CB  1 
ATOM   121  C CG1 . VAL A 1 16  ? -24.55118 8.83048   -12.99758 1.000 7.40494  ? 18  VAL A CG1 1 
ATOM   122  C CG2 . VAL A 1 16  ? -25.11627 8.02324   -15.31628 1.000 3.68223  ? 18  VAL A CG2 1 
ATOM   123  N N   . GLN A 1 17  ? -25.12667 4.73288   -14.15058 1.000 8.21592  ? 19  GLN A N   1 
ATOM   124  C CA  . GLN A 1 17  ? -25.68149 3.55211   -14.78719 1.000 7.72044  ? 19  GLN A CA  1 
ATOM   125  C C   . GLN A 1 17  ? -26.95171 3.94576   -15.53418 1.000 9.39664  ? 19  GLN A C   1 
ATOM   126  O O   . GLN A 1 17  ? -27.77696 4.69553   -15.00157 1.000 9.69926  ? 19  GLN A O   1 
ATOM   127  C CB  . GLN A 1 17  ? -25.97240 2.48813   -13.73478 1.000 9.53450  ? 19  GLN A CB  1 
ATOM   128  C CG  . GLN A 1 17  ? -26.27952 1.12723   -14.29340 1.000 11.46461 ? 19  GLN A CG  1 
ATOM   129  C CD  . GLN A 1 17  ? -26.46169 0.10157   -13.19807 1.000 17.24953 ? 19  GLN A CD  1 
ATOM   130  O OE1 . GLN A 1 17  ? -26.72036 -1.06817  -13.46558 1.000 22.14543 ? 19  GLN A OE1 1 
ATOM   131  N NE2 . GLN A 1 17  ? -26.32843 0.54018   -11.94770 1.000 19.74543 ? 19  GLN A NE2 1 
ATOM   132  N N   . VAL A 1 18  ? -27.08857 3.47448   -16.77309 1.000 9.73638  ? 20  VAL A N   1 
ATOM   133  C CA  . VAL A 1 18  ? -28.26345 3.73064   -17.60685 1.000 9.09417  ? 20  VAL A CA  1 
ATOM   134  C C   . VAL A 1 18  ? -28.85215 2.39110   -18.02716 1.000 8.62733  ? 20  VAL A C   1 
ATOM   135  O O   . VAL A 1 18  ? -28.14566 1.54320   -18.58539 1.000 6.05440  ? 20  VAL A O   1 
ATOM   136  C CB  . VAL A 1 18  ? -27.93306 4.57052   -18.85559 1.000 6.52772  ? 20  VAL A CB  1 
ATOM   137  C CG1 . VAL A 1 18  ? -29.17927 4.68217   -19.75014 1.000 7.32945  ? 20  VAL A CG1 1 
ATOM   138  C CG2 . VAL A 1 18  ? -27.40380 5.93683   -18.49382 1.000 3.21069  ? 20  VAL A CG2 1 
ATOM   139  N N   . THR A 1 19  ? -30.14237 2.20631   -17.76774 1.000 9.16353  ? 21  THR A N   1 
ATOM   140  C CA  . THR A 1 19  ? -30.85278 0.99633   -18.15238 1.000 9.77714  ? 21  THR A CA  1 
ATOM   141  C C   . THR A 1 19  ? -32.07151 1.38242   -18.97437 1.000 15.74131 ? 21  THR A C   1 
ATOM   142  O O   . THR A 1 19  ? -32.84643 2.25749   -18.57642 1.000 16.10476 ? 21  THR A O   1 
ATOM   143  C CB  . THR A 1 19  ? -31.30842 0.17291   -16.93841 1.000 11.62902 ? 21  THR A CB  1 
ATOM   144  O OG1 . THR A 1 19  ? -30.18411 -0.13120  -16.10133 1.000 14.04739 ? 21  THR A OG1 1 
ATOM   145  C CG2 . THR A 1 19  ? -31.96406 -1.13097  -17.39818 1.000 14.79221 ? 21  THR A CG2 1 
ATOM   146  N N   . CYS A 1 20  ? -32.23273 0.73118   -20.11873 1.000 14.07177 ? 22  CYS A N   1 
ATOM   147  C CA  . CYS A 1 20  ? -33.41179 0.88248   -20.95512 1.000 15.00593 ? 22  CYS A CA  1 
ATOM   148  C C   . CYS A 1 20  ? -33.81243 -0.52149  -21.36989 1.000 18.64379 ? 22  CYS A C   1 
ATOM   149  O O   . CYS A 1 20  ? -32.98201 -1.26746  -21.90201 1.000 17.34418 ? 22  CYS A O   1 
ATOM   150  C CB  . CYS A 1 20  ? -33.12166 1.77825   -22.16393 1.000 9.49004  ? 22  CYS A CB  1 
ATOM   151  S SG  . CYS A 1 20  ? -34.50943 1.93639   -23.32356 1.000 20.18725 ? 22  CYS A SG  1 
ATOM   152  N N   . GLY A 1 21  ? -35.05199 -0.90504  -21.06380 1.000 16.90636 ? 23  GLY A N   1 
ATOM   153  C CA  . GLY A 1 21  ? -35.47683 -2.27244  -21.33285 1.000 16.79076 ? 23  GLY A CA  1 
ATOM   154  C C   . GLY A 1 21  ? -34.67675 -3.26142  -20.50035 1.000 19.16068 ? 23  GLY A C   1 
ATOM   155  O O   . GLY A 1 21  ? -34.58008 -3.15166  -19.27332 1.000 20.59783 ? 23  GLY A O   1 
ATOM   156  N N   . THR A 1 22  ? -34.07804 -4.24163  -21.16333 1.000 14.55006 ? 24  THR A N   1 
ATOM   157  C CA  . THR A 1 22  ? -33.26127 -5.23022  -20.47809 1.000 22.76263 ? 24  THR A CA  1 
ATOM   158  C C   . THR A 1 22  ? -31.76767 -4.96704  -20.63434 1.000 16.53519 ? 24  THR A C   1 
ATOM   159  O O   . THR A 1 22  ? -30.95833 -5.84307  -20.31366 1.000 17.94705 ? 24  THR A O   1 
ATOM   160  C CB  . THR A 1 22  ? -33.58614 -6.62097  -21.00217 1.000 18.94776 ? 24  THR A CB  1 
ATOM   161  O OG1 . THR A 1 22  ? -33.54010 -6.59044  -22.43015 1.000 22.19006 ? 24  THR A OG1 1 
ATOM   162  C CG2 . THR A 1 22  ? -34.96545 -7.05014  -20.54779 1.000 23.70730 ? 24  THR A CG2 1 
ATOM   163  N N   . THR A 1 23  ? -31.38936 -3.79422  -21.13323 1.000 16.86014 ? 25  THR A N   1 
ATOM   164  C CA  . THR A 1 23  ? -30.00237 -3.47773  -21.46197 1.000 20.23970 ? 25  THR A CA  1 
ATOM   165  C C   . THR A 1 23  ? -29.47790 -2.42498  -20.50135 1.000 12.91369 ? 25  THR A C   1 
ATOM   166  O O   . THR A 1 23  ? -30.08593 -1.35839  -20.35739 1.000 12.32698 ? 25  THR A O   1 
ATOM   167  C CB  . THR A 1 23  ? -29.87089 -2.97157  -22.90564 1.000 12.73183 ? 25  THR A CB  1 
ATOM   168  O OG1 . THR A 1 23  ? -30.29488 -3.99529  -23.80120 1.000 19.77292 ? 25  THR A OG1 1 
ATOM   169  C CG2 . THR A 1 23  ? -28.42338 -2.63220  -23.22443 1.000 12.94400 ? 25  THR A CG2 1 
ATOM   170  N N   . THR A 1 24  ? -28.34469 -2.71581  -19.86551 1.000 12.97544 ? 26  THR A N   1 
ATOM   171  C CA  . THR A 1 24  ? -27.67461 -1.76727  -18.98897 1.000 10.55717 ? 26  THR A CA  1 
ATOM   172  C C   . THR A 1 24  ? -26.28489 -1.43481  -19.53214 1.000 7.20314  ? 26  THR A C   1 
ATOM   173  O O   . THR A 1 24  ? -25.62595 -2.26934  -20.15404 1.000 7.37390  ? 26  THR A O   1 
ATOM   174  C CB  . THR A 1 24  ? -27.58648 -2.33129  -17.55962 1.000 16.59334 ? 26  THR A CB  1 
ATOM   175  O OG1 . THR A 1 24  ? -28.91521 -2.50475  -17.03502 1.000 15.27701 ? 26  THR A OG1 1 
ATOM   176  C CG2 . THR A 1 24  ? -26.82113 -1.39932  -16.64315 1.000 12.36518 ? 26  THR A CG2 1 
ATOM   177  N N   . LEU A 1 25  ? -25.86082 -0.19129  -19.32674 1.000 6.83326  ? 27  LEU A N   1 
ATOM   178  C CA  . LEU A 1 25  ? -24.51978 0.28037   -19.67846 1.000 7.96049  ? 27  LEU A CA  1 
ATOM   179  C C   . LEU A 1 25  ? -24.28138 1.58251   -18.91480 1.000 6.44529  ? 27  LEU A C   1 
ATOM   180  O O   . LEU A 1 25  ? -25.11340 2.00001   -18.09780 1.000 6.33795  ? 27  LEU A O   1 
ATOM   181  C CB  . LEU A 1 25  ? -24.35326 0.43701   -21.20013 1.000 5.82399  ? 27  LEU A CB  1 
ATOM   182  C CG  . LEU A 1 25  ? -25.42651 1.12311   -22.05911 1.000 5.86880  ? 27  LEU A CG  1 
ATOM   183  C CD1 . LEU A 1 25  ? -25.67475 2.57547   -21.64308 1.000 2.58124  ? 27  LEU A CD1 1 
ATOM   184  C CD2 . LEU A 1 25  ? -25.06414 1.06935   -23.55135 1.000 3.65084  ? 27  LEU A CD2 1 
ATOM   185  N N   . ASN A 1 26  ? -23.16264 2.24578   -19.20716 1.000 5.40704  ? 28  ASN A N   1 
ATOM   186  C CA  . ASN A 1 26  ? -22.67815 3.39278   -18.44460 1.000 4.12416  ? 28  ASN A CA  1 
ATOM   187  C C   . ASN A 1 26  ? -23.08917 4.71125   -19.08524 1.000 4.28721  ? 28  ASN A C   1 
ATOM   188  O O   . ASN A 1 26  ? -23.12758 4.83491   -20.31059 1.000 3.08386  ? 28  ASN A O   1 
ATOM   189  C CB  . ASN A 1 26  ? -21.14716 3.37744   -18.34335 1.000 3.86754  ? 28  ASN A CB  1 
ATOM   190  C CG  . ASN A 1 26  ? -20.60221 2.06703   -17.82998 1.000 5.52218  ? 28  ASN A CG  1 
ATOM   191  O OD1 . ASN A 1 26  ? -20.69914 1.77447   -16.64370 1.000 5.44879  ? 28  ASN A OD1 1 
ATOM   192  N ND2 . ASN A 1 26  ? -19.99863 1.27786   -18.71818 1.000 4.28449  ? 28  ASN A ND2 1 
ATOM   193  N N   . GLY A 1 27  ? -23.31778 5.72629   -18.24243 1.000 5.58486  ? 29  GLY A N   1 
ATOM   194  C CA  . GLY A 1 27  ? -23.47381 7.08950   -18.70148 1.000 4.74446  ? 29  GLY A CA  1 
ATOM   195  C C   . GLY A 1 27  ? -22.46619 8.04122   -18.06449 1.000 6.03537  ? 29  GLY A C   1 
ATOM   196  O O   . GLY A 1 27  ? -21.81590 7.71491   -17.06899 1.000 6.56602  ? 29  GLY A O   1 
ATOM   197  N N   . LEU A 1 28  ? -22.35961 9.23781   -18.65514 1.000 2.93455  ? 30  LEU A N   1 
ATOM   198  C CA  . LEU A 1 28  ? -21.49120 10.30786  -18.17967 1.000 7.33902  ? 30  LEU A CA  1 
ATOM   199  C C   . LEU A 1 28  ? -22.36270 11.49822  -17.78593 1.000 6.40163  ? 30  LEU A C   1 
ATOM   200  O O   . LEU A 1 28  ? -23.02293 12.09934  -18.64135 1.000 6.17461  ? 30  LEU A O   1 
ATOM   201  C CB  . LEU A 1 28  ? -20.46012 10.69755  -19.25116 1.000 3.05258  ? 30  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 28  ? -19.47738 11.81163  -18.89535 1.000 5.15143  ? 30  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 28  ? -18.48218 11.32548  -17.85183 1.000 4.73556  ? 30  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 28  ? -18.75149 12.32639  -20.12882 1.000 4.76308  ? 30  LEU A CD2 1 
ATOM   205  N N   . TRP A 1 29  ? -22.36447 11.83483  -16.48989 1.000 7.76324  ? 31  TRP A N   1 
ATOM   206  C CA  . TRP A 1 29  ? -23.31961 12.77990  -15.90170 1.000 6.89027  ? 31  TRP A CA  1 
ATOM   207  C C   . TRP A 1 29  ? -22.62478 14.11984  -15.68206 1.000 9.14154  ? 31  TRP A C   1 
ATOM   208  O O   . TRP A 1 29  ? -21.90004 14.30769  -14.70257 1.000 9.68887  ? 31  TRP A O   1 
ATOM   209  C CB  . TRP A 1 29  ? -23.87845 12.21769  -14.59721 1.000 8.37435  ? 31  TRP A CB  1 
ATOM   210  C CG  . TRP A 1 29  ? -24.84088 13.12347  -13.84635 1.000 11.01193 ? 31  TRP A CG  1 
ATOM   211  C CD1 . TRP A 1 29  ? -25.59602 14.15493  -14.35770 1.000 11.15031 ? 31  TRP A CD1 1 
ATOM   212  C CD2 . TRP A 1 29  ? -25.15287 13.05673  -12.44633 1.000 9.23394  ? 31  TRP A CD2 1 
ATOM   213  N NE1 . TRP A 1 29  ? -26.34982 14.72997  -13.35562 1.000 12.79543 ? 31  TRP A NE1 1 
ATOM   214  C CE2 . TRP A 1 29  ? -26.10273 14.06791  -12.17727 1.000 14.34850 ? 31  TRP A CE2 1 
ATOM   215  C CE3 . TRP A 1 29  ? -24.72845 12.23196  -11.39808 1.000 9.08381  ? 31  TRP A CE3 1 
ATOM   216  C CZ2 . TRP A 1 29  ? -26.62375 14.28014  -10.89515 1.000 14.91277 ? 31  TRP A CZ2 1 
ATOM   217  C CZ3 . TRP A 1 29  ? -25.24211 12.44601  -10.12952 1.000 13.82799 ? 31  TRP A CZ3 1 
ATOM   218  C CH2 . TRP A 1 29  ? -26.17698 13.46220  -9.88826  1.000 10.23773 ? 31  TRP A CH2 1 
ATOM   219  N N   . LEU A 1 30  ? -22.84947 15.05580  -16.59403 1.000 9.58744  ? 32  LEU A N   1 
ATOM   220  C CA  . LEU A 1 30  ? -22.31065 16.40512  -16.49071 1.000 9.57932  ? 32  LEU A CA  1 
ATOM   221  C C   . LEU A 1 30  ? -23.46688 17.39945  -16.42187 1.000 13.78666 ? 32  LEU A C   1 
ATOM   222  O O   . LEU A 1 30  ? -24.37793 17.34704  -17.25302 1.000 8.30916  ? 32  LEU A O   1 
ATOM   223  C CB  . LEU A 1 30  ? -21.41344 16.71736  -17.68286 1.000 8.10303  ? 32  LEU A CB  1 
ATOM   224  C CG  . LEU A 1 30  ? -20.26971 15.73733  -17.97785 1.000 7.32264  ? 32  LEU A CG  1 
ATOM   225  C CD1 . LEU A 1 30  ? -19.70913 16.02126  -19.35017 1.000 5.92708  ? 32  LEU A CD1 1 
ATOM   226  C CD2 . LEU A 1 30  ? -19.15715 15.83324  -16.92910 1.000 5.95691  ? 32  LEU A CD2 1 
ATOM   227  N N   . ASP A 1 31  ? -23.43191 18.29821  -15.43084 1.000 15.61629 ? 33  ASP A N   1 
ATOM   228  C CA  . ASP A 1 31  ? -24.51652 19.27112  -15.19127 1.000 18.17382 ? 33  ASP A CA  1 
ATOM   229  C C   . ASP A 1 31  ? -25.82168 18.48075  -15.09136 1.000 13.33911 ? 33  ASP A C   1 
ATOM   230  O O   . ASP A 1 31  ? -25.86863 17.47803  -14.36426 1.000 12.97166 ? 33  ASP A O   1 
ATOM   231  C CB  . ASP A 1 31  ? -24.48940 20.34427  -16.26692 1.000 17.71941 ? 33  ASP A CB  1 
ATOM   232  C CG  . ASP A 1 31  ? -23.20319 21.11356  -16.27574 1.000 19.41341 ? 33  ASP A CG  1 
ATOM   233  O OD1 . ASP A 1 31  ? -22.81553 21.61362  -15.19830 1.000 24.97462 ? 33  ASP A OD1 1 
ATOM   234  O OD2 . ASP A 1 31  ? -22.57617 21.21545  -17.35442 1.000 19.98427 ? 33  ASP A OD2 1 
ATOM   235  N N   . ASP A 1 32  ? -26.87107 18.84785  -15.82770 1.000 13.75508 ? 34  ASP A N   1 
ATOM   236  C CA  . ASP A 1 32  ? -28.13442 18.11959  -15.78815 1.000 14.15997 ? 34  ASP A CA  1 
ATOM   237  C C   . ASP A 1 32  ? -28.35036 17.23641  -17.01839 1.000 17.83335 ? 34  ASP A C   1 
ATOM   238  O O   . ASP A 1 32  ? -29.50295 16.94799  -17.38357 1.000 16.49633 ? 34  ASP A O   1 
ATOM   239  C CB  . ASP A 1 32  ? -29.29727 19.09614  -15.61761 1.000 17.47598 ? 34  ASP A CB  1 
ATOM   240  C CG  . ASP A 1 32  ? -29.33577 20.15511  -16.70555 1.000 19.11598 ? 34  ASP A CG  1 
ATOM   241  O OD1 . ASP A 1 32  ? -28.48968 20.12011  -17.61688 1.000 16.34772 ? 34  ASP A OD1 1 
ATOM   242  O OD2 . ASP A 1 32  ? -30.21611 21.02887  -16.64563 1.000 28.62439 ? 34  ASP A OD2 1 
ATOM   243  N N   . VAL A 1 33  ? -27.26901 16.78278  -17.65730 1.000 12.99811 ? 35  VAL A N   1 
ATOM   244  C CA  . VAL A 1 33  ? -27.34512 15.91194  -18.82730 1.000 8.14792  ? 35  VAL A CA  1 
ATOM   245  C C   . VAL A 1 33  ? -26.56286 14.62976  -18.55528 1.000 10.34116 ? 35  VAL A C   1 
ATOM   246  O O   . VAL A 1 33  ? -25.41347 14.67686  -18.09657 1.000 8.77262  ? 35  VAL A O   1 
ATOM   247  C CB  . VAL A 1 33  ? -26.80186 16.61685  -20.08462 1.000 8.70873  ? 35  VAL A CB  1 
ATOM   248  C CG1 . VAL A 1 33  ? -27.00203 15.73918  -21.30901 1.000 7.31729  ? 35  VAL A CG1 1 
ATOM   249  C CG2 . VAL A 1 33  ? -27.49382 17.95369  -20.27959 1.000 10.37850 ? 35  VAL A CG2 1 
ATOM   250  N N   . VAL A 1 34  ? -27.17626 13.48847  -18.84763 1.000 7.52937  ? 36  VAL A N   1 
ATOM   251  C CA  . VAL A 1 34  ? -26.47509 12.21013  -18.87720 1.000 8.06729  ? 36  VAL A CA  1 
ATOM   252  C C   . VAL A 1 34  ? -26.25232 11.82109  -20.33626 1.000 7.81416  ? 36  VAL A C   1 
ATOM   253  O O   . VAL A 1 34  ? -27.21020 11.71868  -21.11188 1.000 6.16250  ? 36  VAL A O   1 
ATOM   254  C CB  . VAL A 1 34  ? -27.24138 11.11751  -18.12030 1.000 6.78267  ? 36  VAL A CB  1 
ATOM   255  C CG1 . VAL A 1 34  ? -26.51464 9.79792   -18.24204 1.000 4.61241  ? 36  VAL A CG1 1 
ATOM   256  C CG2 . VAL A 1 34  ? -27.36311 11.50273  -16.65291 1.000 8.38309  ? 36  VAL A CG2 1 
ATOM   257  N N   . TYR A 1 35  ? -24.99083 11.61216  -20.71525 1.000 5.50946  ? 37  TYR A N   1 
ATOM   258  C CA  . TYR A 1 35  ? -24.64309 11.16552  -22.06202 1.000 5.74414  ? 37  TYR A CA  1 
ATOM   259  C C   . TYR A 1 35  ? -24.38899 9.66503   -22.05282 1.000 4.58474  ? 37  TYR A C   1 
ATOM   260  O O   . TYR A 1 35  ? -23.72780 9.14438   -21.15161 1.000 6.59297  ? 37  TYR A O   1 
ATOM   261  C CB  . TYR A 1 35  ? -23.40222 11.88026  -22.59487 1.000 6.57163  ? 37  TYR A CB  1 
ATOM   262  C CG  . TYR A 1 35  ? -23.46269 13.38944  -22.55131 1.000 9.50430  ? 37  TYR A CG  1 
ATOM   263  C CD1 . TYR A 1 35  ? -23.28035 14.06567  -21.35670 1.000 6.93626  ? 37  TYR A CD1 1 
ATOM   264  C CD2 . TYR A 1 35  ? -23.66936 14.14046  -23.71480 1.000 8.98910  ? 37  TYR A CD2 1 
ATOM   265  C CE1 . TYR A 1 35  ? -23.33344 15.43806  -21.29506 1.000 6.44851  ? 37  TYR A CE1 1 
ATOM   266  C CE2 . TYR A 1 35  ? -23.71170 15.53727  -23.66755 1.000 9.48567  ? 37  TYR A CE2 1 
ATOM   267  C CZ  . TYR A 1 35  ? -23.54560 16.16688  -22.44026 1.000 10.35240 ? 37  TYR A CZ  1 
ATOM   268  O OH  . TYR A 1 35  ? -23.57663 17.52698  -22.33780 1.000 9.39940  ? 37  TYR A OH  1 
ATOM   269  N N   . CYS A 1 36  ? -24.90030 8.97219   -23.05855 1.000 2.36491  ? 38  CYS A N   1 
ATOM   270  C CA  . CYS A 1 36  ? -24.63388 7.54807   -23.18538 1.000 4.59195  ? 38  CYS A CA  1 
ATOM   271  C C   . CYS A 1 36  ? -24.74308 7.16942   -24.65711 1.000 5.16207  ? 38  CYS A C   1 
ATOM   272  O O   . CYS A 1 36  ? -25.20614 7.96718   -25.48074 1.000 5.90669  ? 38  CYS A O   1 
ATOM   273  C CB  . CYS A 1 36  ? -25.58665 6.72661   -22.31108 1.000 7.02541  ? 38  CYS A CB  1 
ATOM   274  S SG  . CYS A 1 36  ? -27.32115 6.65690   -22.86279 1.000 5.65511  ? 38  CYS A SG  1 
ATOM   275  N N   . PRO A 1 37  ? -24.27132 5.97560   -25.02784 1.000 3.82987  ? 39  PRO A N   1 
ATOM   276  C CA  . PRO A 1 37  ? -24.45005 5.53811   -26.42415 1.000 5.94132  ? 39  PRO A CA  1 
ATOM   277  C C   . PRO A 1 37  ? -25.92063 5.32186   -26.73997 1.000 4.23649  ? 39  PRO A C   1 
ATOM   278  O O   . PRO A 1 37  ? -26.65211 4.69657   -25.97044 1.000 3.75665  ? 39  PRO A O   1 
ATOM   279  C CB  . PRO A 1 37  ? -23.66664 4.21899   -26.50025 1.000 3.00333  ? 39  PRO A CB  1 
ATOM   280  C CG  . PRO A 1 37  ? -22.70921 4.25245   -25.29261 1.000 2.87284  ? 39  PRO A CG  1 
ATOM   281  C CD  . PRO A 1 37  ? -23.46078 5.02127   -24.23837 1.000 2.98308  ? 39  PRO A CD  1 
ATOM   282  N N   . ARG A 1 38  ? -26.34676 5.81980   -27.90324 1.000 5.74472  ? 40  ARG A N   1 
ATOM   283  C CA  . ARG A 1 38  ? -27.75403 5.66384   -28.26461 1.000 8.28626  ? 40  ARG A CA  1 
ATOM   284  C C   . ARG A 1 38  ? -28.13563 4.20694   -28.46571 1.000 7.88656  ? 40  ARG A C   1 
ATOM   285  O O   . ARG A 1 38  ? -29.32917 3.88148   -28.39726 1.000 3.22397  ? 40  ARG A O   1 
ATOM   286  C CB  . ARG A 1 38  ? -28.08483 6.45565   -29.52474 1.000 5.43941  ? 40  ARG A CB  1 
ATOM   287  C CG  . ARG A 1 38  ? -27.62420 5.80894   -30.79382 1.000 6.10143  ? 40  ARG A CG  1 
ATOM   288  C CD  . ARG A 1 38  ? -27.92613 6.70428   -32.00149 1.000 6.24008  ? 40  ARG A CD  1 
ATOM   289  N NE  . ARG A 1 38  ? -27.32248 6.16503   -33.20688 1.000 5.74260  ? 40  ARG A NE  1 
ATOM   290  C CZ  . ARG A 1 38  ? -27.62275 6.56849   -34.43462 1.000 8.87312  ? 40  ARG A CZ  1 
ATOM   291  N NH1 . ARG A 1 38  ? -28.53148 7.52082   -34.62022 1.000 7.73044  ? 40  ARG A NH1 1 
ATOM   292  N NH2 . ARG A 1 38  ? -27.02833 6.00624   -35.47043 1.000 6.07058  ? 40  ARG A NH2 1 
ATOM   293  N N   . HIS A 1 39  ? -27.15811 3.31476   -28.69063 1.000 4.07154  ? 41  HIS A N   1 
ATOM   294  C CA  . HIS A 1 39  ? -27.55274 1.92067   -28.87822 1.000 4.56271  ? 41  HIS A CA  1 
ATOM   295  C C   . HIS A 1 39  ? -28.09348 1.25909   -27.60007 1.000 5.09879  ? 41  HIS A C   1 
ATOM   296  O O   . HIS A 1 39  ? -28.48457 0.08887   -27.66453 1.000 6.33460  ? 41  HIS A O   1 
ATOM   297  C CB  . HIS A 1 39  ? -26.40220 1.10835   -29.50761 1.000 4.27480  ? 41  HIS A CB  1 
ATOM   298  C CG  . HIS A 1 39  ? -25.24433 0.78069   -28.60365 1.000 7.70576  ? 41  HIS A CG  1 
ATOM   299  N ND1 . HIS A 1 39  ? -25.36055 0.00943   -27.46204 1.000 7.71929  ? 41  HIS A ND1 1 
ATOM   300  C CD2 . HIS A 1 39  ? -23.91791 1.02034   -28.75629 1.000 3.38751  ? 41  HIS A CD2 1 
ATOM   301  C CE1 . HIS A 1 39  ? -24.16484 -0.16916  -26.93016 1.000 7.54943  ? 41  HIS A CE1 1 
ATOM   302  N NE2 . HIS A 1 39  ? -23.27367 0.43471   -27.69716 1.000 5.88930  ? 41  HIS A NE2 1 
ATOM   303  N N   . VAL A 1 40  ? -28.15662 1.96622   -26.46370 1.000 2.73238  ? 42  VAL A N   1 
ATOM   304  C CA  . VAL A 1 40  ? -28.86779 1.43891   -25.29506 1.000 6.40494  ? 42  VAL A CA  1 
ATOM   305  C C   . VAL A 1 40  ? -30.34845 1.17760   -25.59461 1.000 7.94459  ? 42  VAL A C   1 
ATOM   306  O O   . VAL A 1 40  ? -30.96750 0.32175   -24.94856 1.000 7.79369  ? 42  VAL A O   1 
ATOM   307  C CB  . VAL A 1 40  ? -28.71814 2.38540   -24.08671 1.000 5.98350  ? 42  VAL A CB  1 
ATOM   308  C CG1 . VAL A 1 40  ? -29.50615 3.67850   -24.29628 1.000 4.67141  ? 42  VAL A CG1 1 
ATOM   309  C CG2 . VAL A 1 40  ? -29.13760 1.68730   -22.79892 1.000 7.62103  ? 42  VAL A CG2 1 
ATOM   310  N N   . ILE A 1 41  ? -30.94086 1.88583   -26.56988 1.000 6.12103  ? 43  ILE A N   1 
ATOM   311  C CA  . ILE A 1 41  ? -32.35447 1.65587   -26.91567 1.000 9.93245  ? 43  ILE A CA  1 
ATOM   312  C C   . ILE A 1 41  ? -32.55010 0.58319   -27.98781 1.000 13.04679 ? 43  ILE A C   1 
ATOM   313  O O   . ILE A 1 41  ? -33.69184 0.33736   -28.40639 1.000 13.90753 ? 43  ILE A O   1 
ATOM   314  C CB  . ILE A 1 41  ? -33.07728 2.93157   -27.40362 1.000 8.99066  ? 43  ILE A CB  1 
ATOM   315  C CG1 . ILE A 1 41  ? -32.64527 3.29745   -28.83275 1.000 5.33709  ? 43  ILE A CG1 1 
ATOM   316  C CG2 . ILE A 1 41  ? -32.90740 4.08449   -26.41080 1.000 5.38106  ? 43  ILE A CG2 1 
ATOM   317  C CD1 . ILE A 1 41  ? -33.23640 4.62758   -29.33690 1.000 7.25727  ? 43  ILE A CD1 1 
ATOM   318  N N   . CYS A 1 42  ? -31.47830 -0.05910  -28.44861 1.000 10.81275 ? 44  CYS A N   1 
ATOM   319  C CA  . CYS A 1 42  ? -31.59666 -1.17432  -29.38114 1.000 11.88906 ? 44  CYS A CA  1 
ATOM   320  C C   . CYS A 1 42  ? -32.16597 -2.41113  -28.68062 1.000 17.15359 ? 44  CYS A C   1 
ATOM   321  O O   . CYS A 1 42  ? -31.88672 -2.65489  -27.50551 1.000 14.55230 ? 44  CYS A O   1 
ATOM   322  C CB  . CYS A 1 42  ? -30.22039 -1.47379  -29.95856 1.000 13.16423 ? 44  CYS A CB  1 
ATOM   323  S SG  . CYS A 1 42  ? -30.18709 -2.32255  -31.48283 1.000 17.60179 ? 44  CYS A SG  1 
ATOM   324  N N   . THR A 1 43  ? -32.99065 -3.18695  -29.38915 1.000 18.99409 ? 45  THR A N   1 
ATOM   325  C CA  . THR A 1 43  ? -33.49259 -4.44958  -28.85291 1.000 18.38695 ? 45  THR A CA  1 
ATOM   326  C C   . THR A 1 43  ? -32.70318 -5.62066  -29.42612 1.000 18.88922 ? 45  THR A C   1 
ATOM   327  O O   . THR A 1 43  ? -31.92627 -5.47861  -30.37120 1.000 19.94322 ? 45  THR A O   1 
ATOM   328  C CB  . THR A 1 43  ? -34.98966 -4.65552  -29.15252 1.000 21.30425 ? 45  THR A CB  1 
ATOM   329  O OG1 . THR A 1 43  ? -35.15937 -5.00057  -30.53489 1.000 20.12630 ? 45  THR A OG1 1 
ATOM   330  C CG2 . THR A 1 43  ? -35.81072 -3.41565  -28.83488 1.000 19.29518 ? 45  THR A CG2 1 
ATOM   331  N N   . SER A 1 44  ? -32.94765 -6.80603  -28.85939 1.000 23.31503 ? 46  SER A N   1 
ATOM   332  C CA  . SER A 1 44  ? -32.20672 -8.00042  -29.26210 1.000 28.36517 ? 46  SER A CA  1 
ATOM   333  C C   . SER A 1 44  ? -32.46524 -8.38688  -30.71731 1.000 33.21879 ? 46  SER A C   1 
ATOM   334  O O   . SER A 1 44  ? -31.60192 -9.00889  -31.34895 1.000 33.11176 ? 46  SER A O   1 
ATOM   335  C CB  . SER A 1 44  ? -32.55470 -9.16516  -28.33634 1.000 36.65407 ? 46  SER A CB  1 
ATOM   336  O OG  . SER A 1 44  ? -32.65652 -8.72923  -26.99242 1.000 37.50140 ? 46  SER A OG  1 
ATOM   337  N N   . GLU A 1 45  ? -33.63799 -8.04333  -31.26546 1.000 31.53891 ? 47  GLU A N   1 
ATOM   338  C CA  . GLU A 1 45  ? -33.91512 -8.20802  -32.69215 1.000 23.93613 ? 47  GLU A CA  1 
ATOM   339  C C   . GLU A 1 45  ? -33.60834 -6.95884  -33.50851 1.000 29.22848 ? 47  GLU A C   1 
ATOM   340  O O   . GLU A 1 45  ? -33.69445 -7.00277  -34.74116 1.000 30.31898 ? 47  GLU A O   1 
ATOM   341  C CB  . GLU A 1 45  ? -35.38495 -8.58788  -32.91405 1.000 44.20480 ? 47  GLU A CB  1 
ATOM   342  C CG  . GLU A 1 45  ? -35.83749 -9.83387  -32.18503 1.000 47.31903 ? 47  GLU A CG  1 
ATOM   343  C CD  . GLU A 1 45  ? -35.99288 -9.60866  -30.69373 1.000 49.07340 ? 47  GLU A CD  1 
ATOM   344  O OE1 . GLU A 1 45  ? -36.80764 -8.74601  -30.29785 1.000 45.72896 ? 47  GLU A OE1 1 
ATOM   345  O OE2 . GLU A 1 45  ? -35.28086 -10.28446 -29.91961 1.000 54.18767 ? 47  GLU A OE2 1 
ATOM   346  N N   . ASP A 1 46  ? -33.30529 -5.83965  -32.85155 1.000 34.59076 ? 48  ASP A N   1 
ATOM   347  C CA  . ASP A 1 46  ? -32.98209 -4.60296  -33.54362 1.000 27.22800 ? 48  ASP A CA  1 
ATOM   348  C C   . ASP A 1 46  ? -31.56877 -4.59460  -34.07092 1.000 19.47196 ? 48  ASP A C   1 
ATOM   349  O O   . ASP A 1 46  ? -31.23931 -3.70997  -34.86243 1.000 31.10797 ? 48  ASP A O   1 
ATOM   350  C CB  . ASP A 1 46  ? -33.12043 -3.39805  -32.61588 1.000 18.14117 ? 48  ASP A CB  1 
ATOM   351  C CG  . ASP A 1 46  ? -34.46021 -2.74808  -32.68181 1.000 27.16362 ? 48  ASP A CG  1 
ATOM   352  O OD1 . ASP A 1 46  ? -35.09908 -2.70477  -33.76343 1.000 30.29601 ? 48  ASP A OD1 1 
ATOM   353  O OD2 . ASP A 1 46  ? -34.85941 -2.24114  -31.60835 1.000 41.71537 ? 48  ASP A OD2 1 
ATOM   354  N N   . MET A 1 47  ? -30.72335 -5.53447  -33.64075 1.000 22.63187 ? 49  MET A N   1 
ATOM   355  C CA  . MET A 1 47  ? -29.29197 -5.24801  -33.59014 1.000 15.47855 ? 49  MET A CA  1 
ATOM   356  C C   . MET A 1 47  ? -28.67354 -5.09580  -34.97163 1.000 16.95340 ? 49  MET A C   1 
ATOM   357  O O   . MET A 1 47  ? -27.65443 -4.41435  -35.10744 1.000 12.77432 ? 49  MET A O   1 
ATOM   358  C CB  . MET A 1 47  ? -28.57384 -6.32970  -32.78949 1.000 20.16814 ? 49  MET A CB  1 
ATOM   359  C CG  . MET A 1 47  ? -29.03255 -6.41947  -31.32777 1.000 19.22877 ? 49  MET A CG  1 
ATOM   360  S SD  . MET A 1 47  ? -27.80853 -7.15251  -30.21045 1.000 25.13150 ? 49  MET A SD  1 
ATOM   361  C CE  . MET A 1 47  ? -27.41206 -8.66248  -31.08408 1.000 22.97033 ? 49  MET A CE  1 
ATOM   362  N N   . LEU A 1 48  ? -29.27452 -5.69940  -36.00232 1.000 18.75464 ? 50  LEU A N   1 
ATOM   363  C CA  . LEU A 1 48  ? -28.67694 -5.67544  -37.33680 1.000 13.20344 ? 50  LEU A CA  1 
ATOM   364  C C   . LEU A 1 48  ? -29.04700 -4.41498  -38.10432 1.000 9.34056  ? 50  LEU A C   1 
ATOM   365  O O   . LEU A 1 48  ? -28.19673 -3.83046  -38.77815 1.000 11.00234 ? 50  LEU A O   1 
ATOM   366  C CB  . LEU A 1 48  ? -29.10028 -6.91286  -38.12877 1.000 12.85032 ? 50  LEU A CB  1 
ATOM   367  C CG  . LEU A 1 48  ? -28.36678 -8.20357  -37.78597 1.000 18.01715 ? 50  LEU A CG  1 
ATOM   368  C CD1 . LEU A 1 48  ? -29.23275 -9.37761  -38.12114 1.000 19.55925 ? 50  LEU A CD1 1 
ATOM   369  C CD2 . LEU A 1 48  ? -27.03835 -8.30451  -38.53172 1.000 20.51193 ? 50  LEU A CD2 1 
ATOM   370  N N   . ASN A 1 49  ? -30.30408 -3.97619  -38.02255 1.000 12.60526 ? 51  ASN A N   1 
ATOM   371  C CA  . ASN A 1 49  ? -30.75702 -2.78904  -38.74994 1.000 9.38313  ? 51  ASN A CA  1 
ATOM   372  C C   . ASN A 1 49  ? -31.72666 -1.98491  -37.89385 1.000 15.27776 ? 51  ASN A C   1 
ATOM   373  O O   . ASN A 1 49  ? -32.90038 -1.83412  -38.23175 1.000 16.21162 ? 51  ASN A O   1 
ATOM   374  C CB  . ASN A 1 49  ? -31.38788 -3.18912  -40.08055 1.000 9.31201  ? 51  ASN A CB  1 
ATOM   375  C CG  . ASN A 1 49  ? -30.35142 -3.66910  -41.08776 1.000 8.24068  ? 51  ASN A CG  1 
ATOM   376  O OD1 . ASN A 1 49  ? -29.64254 -2.87003  -41.68260 1.000 9.49440  ? 51  ASN A OD1 1 
ATOM   377  N ND2 . ASN A 1 49  ? -30.25810 -4.97536  -41.26808 1.000 7.90027  ? 51  ASN A ND2 1 
ATOM   378  N N   . PRO A 1 50  ? -31.25700 -1.43008  -36.77990 1.000 13.56094 ? 52  PRO A N   1 
ATOM   379  C CA  . PRO A 1 50  ? -32.12719 -0.56756  -35.98484 1.000 14.85229 ? 52  PRO A CA  1 
ATOM   380  C C   . PRO A 1 50  ? -32.33008 0.76512   -36.68204 1.000 12.50411 ? 52  PRO A C   1 
ATOM   381  O O   . PRO A 1 50  ? -31.44585 1.26532   -37.37748 1.000 10.29749 ? 52  PRO A O   1 
ATOM   382  C CB  . PRO A 1 50  ? -31.35739 -0.40230  -34.66941 1.000 13.92503 ? 52  PRO A CB  1 
ATOM   383  C CG  . PRO A 1 50  ? -29.93102 -0.52860  -35.05955 1.000 13.58363 ? 52  PRO A CG  1 
ATOM   384  C CD  . PRO A 1 50  ? -29.86842 -1.42738  -36.27182 1.000 16.97008 ? 52  PRO A CD  1 
ATOM   385  N N   . ASN A 1 51  ? -33.53227 1.32024   -36.52179 1.000 9.21196  ? 53  ASN A N   1 
ATOM   386  C CA  . ASN A 1 51  ? -33.84428 2.68515   -36.93929 1.000 5.19193  ? 53  ASN A CA  1 
ATOM   387  C C   . ASN A 1 51  ? -33.98206 3.46506   -35.64115 1.000 8.34085  ? 53  ASN A C   1 
ATOM   388  O O   . ASN A 1 51  ? -35.01251 3.37917   -34.96123 1.000 8.06920  ? 53  ASN A O   1 
ATOM   389  C CB  . ASN A 1 51  ? -35.12230 2.75653   -37.78910 1.000 7.77099  ? 53  ASN A CB  1 
ATOM   390  C CG  . ASN A 1 51  ? -35.33074 4.13193   -38.42496 1.000 9.60179  ? 53  ASN A CG  1 
ATOM   391  O OD1 . ASN A 1 51  ? -35.51909 5.13258   -37.73222 1.000 9.52171  ? 53  ASN A OD1 1 
ATOM   392  N ND2 . ASN A 1 51  ? -35.28055 4.18416   -39.75337 1.000 18.02910 ? 53  ASN A ND2 1 
ATOM   393  N N   . TYR A 1 52  ? -32.94073 4.22537   -35.29712 1.000 5.66088  ? 54  TYR A N   1 
ATOM   394  C CA  . TYR A 1 52  ? -32.89373 4.84155   -33.97748 1.000 10.39435 ? 54  TYR A CA  1 
ATOM   395  C C   . TYR A 1 52  ? -33.90296 5.97634   -33.82816 1.000 7.63419  ? 54  TYR A C   1 
ATOM   396  O O   . TYR A 1 52  ? -34.37735 6.22945   -32.71870 1.000 6.96157  ? 54  TYR A O   1 
ATOM   397  C CB  . TYR A 1 52  ? -31.47219 5.33754   -33.68381 1.000 9.27358  ? 54  TYR A CB  1 
ATOM   398  C CG  . TYR A 1 52  ? -30.53032 4.20801   -33.36339 1.000 8.81138  ? 54  TYR A CG  1 
ATOM   399  C CD1 . TYR A 1 52  ? -30.61136 3.54538   -32.15021 1.000 9.57888  ? 54  TYR A CD1 1 
ATOM   400  C CD2 . TYR A 1 52  ? -29.59204 3.77546   -34.29333 1.000 6.61254  ? 54  TYR A CD2 1 
ATOM   401  C CE1 . TYR A 1 52  ? -29.76270 2.50066   -31.84962 1.000 9.86287  ? 54  TYR A CE1 1 
ATOM   402  C CE2 . TYR A 1 52  ? -28.74217 2.72661   -34.01197 1.000 7.09585  ? 54  TYR A CE2 1 
ATOM   403  C CZ  . TYR A 1 52  ? -28.82854 2.09141   -32.78844 1.000 10.60461 ? 54  TYR A CZ  1 
ATOM   404  O OH  . TYR A 1 52  ? -27.98195 1.04114   -32.49624 1.000 8.99276  ? 54  TYR A OH  1 
ATOM   405  N N   . GLU A 1 53  ? -34.21021 6.69073   -34.91071 1.000 8.76639  ? 55  GLU A N   1 
ATOM   406  C CA  . GLU A 1 53  ? -35.21590 7.74329   -34.83289 1.000 10.82395 ? 55  GLU A CA  1 
ATOM   407  C C   . GLU A 1 53  ? -36.58819 7.16405   -34.48941 1.000 11.84150 ? 55  GLU A C   1 
ATOM   408  O O   . GLU A 1 53  ? -37.32626 7.74781   -33.68642 1.000 7.89585  ? 55  GLU A O   1 
ATOM   409  C CB  . GLU A 1 53  ? -35.26069 8.52054   -36.14948 1.000 12.11169 ? 55  GLU A CB  1 
ATOM   410  C CG  . GLU A 1 53  ? -36.11712 9.79102   -36.10193 1.000 24.29599 ? 55  GLU A CG  1 
ATOM   411  C CD  . GLU A 1 53  ? -36.65641 10.21286  -37.47631 1.000 31.52426 ? 55  GLU A CD  1 
ATOM   412  O OE1 . GLU A 1 53  ? -37.79900 10.72540  -37.54112 1.000 28.04768 ? 55  GLU A OE1 1 
ATOM   413  O OE2 . GLU A 1 53  ? -35.94037 10.03823  -38.48579 1.000 32.68046 ? 55  GLU A OE2 1 
ATOM   414  N N   . ASP A 1 54  ? -36.92973 6.00093   -35.07456 1.000 7.65965  ? 56  ASP A N   1 
ATOM   415  C CA  . ASP A 1 54  ? -38.19038 5.31745   -34.77931 1.000 10.62348 ? 56  ASP A CA  1 
ATOM   416  C C   . ASP A 1 54  ? -38.17507 4.69007   -33.39000 1.000 13.52863 ? 56  ASP A C   1 
ATOM   417  O O   . ASP A 1 54  ? -39.18090 4.73923   -32.66586 1.000 7.45499  ? 56  ASP A O   1 
ATOM   418  C CB  . ASP A 1 54  ? -38.46691 4.24394   -35.83629 1.000 8.06167  ? 56  ASP A CB  1 
ATOM   419  C CG  . ASP A 1 54  ? -39.94668 3.89466   -35.95300 1.000 14.01849 ? 56  ASP A CG  1 
ATOM   420  O OD1 . ASP A 1 54  ? -40.74194 4.74984   -36.41093 1.000 18.05671 ? 56  ASP A OD1 1 
ATOM   421  O OD2 . ASP A 1 54  ? -40.31858 2.75241   -35.61221 1.000 13.60673 ? 56  ASP A OD2 1 
ATOM   422  N N   . LEU A 1 55  ? -37.05360 4.07257   -33.00289 1.000 8.44931  ? 57  LEU A N   1 
ATOM   423  C CA  . LEU A 1 55  ? -36.97017 3.53840   -31.65121 1.000 6.97837  ? 57  LEU A CA  1 
ATOM   424  C C   . LEU A 1 55  ? -37.11397 4.65213   -30.62685 1.000 6.33741  ? 57  LEU A C   1 
ATOM   425  O O   . LEU A 1 55  ? -37.73616 4.46351   -29.57203 1.000 10.87376 ? 57  LEU A O   1 
ATOM   426  C CB  . LEU A 1 55  ? -35.65236 2.78227   -31.45139 1.000 9.28929  ? 57  LEU A CB  1 
ATOM   427  C CG  . LEU A 1 55  ? -35.49237 1.50654   -32.28138 1.000 11.04119 ? 57  LEU A CG  1 
ATOM   428  C CD1 . LEU A 1 55  ? -34.05139 1.02803   -32.26582 1.000 14.99419 ? 57  LEU A CD1 1 
ATOM   429  C CD2 . LEU A 1 55  ? -36.42615 0.41563   -31.80322 1.000 8.76405  ? 57  LEU A CD2 1 
ATOM   430  N N   . LEU A 1 56  ? -36.57649 5.83285   -30.92948 1.000 8.46674  ? 58  LEU A N   1 
ATOM   431  C CA  . LEU A 1 56  ? -36.56935 6.88600   -29.91981 1.000 10.41906 ? 58  LEU A CA  1 
ATOM   432  C C   . LEU A 1 56  ? -37.95228 7.50639   -29.74753 1.000 10.71188 ? 58  LEU A C   1 
ATOM   433  O O   . LEU A 1 56  ? -38.38196 7.76481   -28.61370 1.000 9.51070  ? 58  LEU A O   1 
ATOM   434  C CB  . LEU A 1 56  ? -35.54817 7.96639   -30.27480 1.000 9.03899  ? 58  LEU A CB  1 
ATOM   435  C CG  . LEU A 1 56  ? -35.24174 8.93328   -29.13312 1.000 7.88636  ? 58  LEU A CG  1 
ATOM   436  C CD1 . LEU A 1 56  ? -35.12518 8.17324   -27.81972 1.000 13.67607 ? 58  LEU A CD1 1 
ATOM   437  C CD2 . LEU A 1 56  ? -33.96664 9.72493   -29.39178 1.000 8.49994  ? 58  LEU A CD2 1 
ATOM   438  N N   . ILE A 1 57  ? -38.66626 7.73832   -30.85506 1.000 8.81384  ? 59  ILE A N   1 
ATOM   439  C CA  . ILE A 1 57  ? -39.94766 8.43640   -30.76936 1.000 11.69081 ? 59  ILE A CA  1 
ATOM   440  C C   . ILE A 1 57  ? -40.93169 7.66370   -29.88840 1.000 10.90853 ? 59  ILE A C   1 
ATOM   441  O O   . ILE A 1 57  ? -41.80532 8.26235   -29.24675 1.000 12.51100 ? 59  ILE A O   1 
ATOM   442  C CB  . ILE A 1 57  ? -40.49853 8.71309   -32.18929 1.000 10.62827 ? 59  ILE A CB  1 
ATOM   443  C CG1 . ILE A 1 57  ? -41.52229 9.85320   -32.15130 1.000 9.29030  ? 59  ILE A CG1 1 
ATOM   444  C CG2 . ILE A 1 57  ? -41.08814 7.44203   -32.82278 1.000 10.84983 ? 59  ILE A CG2 1 
ATOM   445  C CD1 . ILE A 1 57  ? -41.73808 10.54287  -33.48274 1.000 8.48282  ? 59  ILE A CD1 1 
ATOM   446  N N   . ARG A 1 58  ? -40.75465 6.34347   -29.78073 1.000 9.22277  ? 60  ARG A N   1 
ATOM   447  C CA  . ARG A 1 58  ? -41.60791 5.46059   -28.99737 1.000 7.52221  ? 60  ARG A CA  1 
ATOM   448  C C   . ARG A 1 58  ? -41.25990 5.41366   -27.51861 1.000 10.99741 ? 60  ARG A C   1 
ATOM   449  O O   . ARG A 1 58  ? -42.00346 4.77902   -26.75559 1.000 10.49221 ? 60  ARG A O   1 
ATOM   450  C CB  . ARG A 1 58  ? -41.53417 4.03870   -29.54946 1.000 6.95901  ? 60  ARG A CB  1 
ATOM   451  C CG  . ARG A 1 58  ? -41.83084 3.93510   -31.02564 1.000 3.71627  ? 60  ARG A CG  1 
ATOM   452  C CD  . ARG A 1 58  ? -41.64328 2.50682   -31.47183 1.000 0.40738  ? 60  ARG A CD  1 
ATOM   453  N NE  . ARG A 1 58  ? -41.74921 2.39151   -32.91855 1.000 2.23287  ? 60  ARG A NE  1 
ATOM   454  C CZ  . ARG A 1 58  ? -42.85233 2.06793   -33.58947 1.000 5.38657  ? 60  ARG A CZ  1 
ATOM   455  N NH1 . ARG A 1 58  ? -43.99477 1.83433   -32.94448 1.000 3.72497  ? 60  ARG A NH1 1 
ATOM   456  N NH2 . ARG A 1 58  ? -42.80993 1.97864   -34.91570 1.000 2.51503  ? 60  ARG A NH2 1 
ATOM   457  N N   . LYS A 1 59  ? -40.15212 6.02629   -27.10447 1.000 9.87958  ? 61  LYS A N   1 
ATOM   458  C CA  . LYS A 1 59  ? -39.76302 6.07259   -25.70253 1.000 12.79789 ? 61  LYS A CA  1 
ATOM   459  C C   . LYS A 1 59  ? -40.34571 7.31390   -25.03784 1.000 12.85058 ? 61  LYS A C   1 
ATOM   460  O O   . LYS A 1 59  ? -40.45640 8.37737   -25.65351 1.000 12.33301 ? 61  LYS A O   1 
ATOM   461  C CB  . LYS A 1 59  ? -38.23230 6.09741   -25.54627 1.000 16.67804 ? 61  LYS A CB  1 
ATOM   462  C CG  . LYS A 1 59  ? -37.48049 4.88756   -26.08633 1.000 11.53601 ? 61  LYS A CG  1 
ATOM   463  C CD  . LYS A 1 59  ? -38.04808 3.62552   -25.50400 1.000 15.89728 ? 61  LYS A CD  1 
ATOM   464  C CE  . LYS A 1 59  ? -37.45678 2.40059   -26.15217 1.000 14.63473 ? 61  LYS A CE  1 
ATOM   465  N NZ  . LYS A 1 59  ? -37.00964 1.50416   -25.05923 1.000 12.47063 ? 61  LYS A NZ  1 
ATOM   466  N N   . SER A 1 60  ? -40.71506 7.17107   -23.76990 1.000 8.15889  ? 62  SER A N   1 
ATOM   467  C CA  . SER A 1 60  ? -40.92767 8.32116   -22.90712 1.000 15.99558 ? 62  SER A CA  1 
ATOM   468  C C   . SER A 1 60  ? -39.84250 8.36190   -21.83728 1.000 17.62857 ? 62  SER A C   1 
ATOM   469  O O   . SER A 1 60  ? -39.00694 7.45944   -21.71593 1.000 16.23608 ? 62  SER A O   1 
ATOM   470  C CB  . SER A 1 60  ? -42.33719 8.31726   -22.28682 1.000 22.61317 ? 62  SER A CB  1 
ATOM   471  O OG  . SER A 1 60  ? -42.72236 7.04737   -21.79639 1.000 25.55314 ? 62  SER A OG  1 
ATOM   472  N N   . ASN A 1 61  ? -39.87198 9.43893   -21.05532 1.000 20.39229 ? 63  ASN A N   1 
ATOM   473  C CA  . ASN A 1 61  ? -38.84118 9.67588   -20.05651 1.000 17.94195 ? 63  ASN A CA  1 
ATOM   474  C C   . ASN A 1 61  ? -38.69898 8.49639   -19.09882 1.000 21.31828 ? 63  ASN A C   1 
ATOM   475  O O   . ASN A 1 61  ? -37.57322 8.11763   -18.73552 1.000 10.30330 ? 63  ASN A O   1 
ATOM   476  C CB  . ASN A 1 61  ? -39.15188 10.97350  -19.31538 1.000 15.55994 ? 63  ASN A CB  1 
ATOM   477  C CG  . ASN A 1 61  ? -38.92310 12.19593  -20.18688 1.000 19.87546 ? 63  ASN A CG  1 
ATOM   478  O OD1 . ASN A 1 61  ? -38.08598 12.17223  -21.08709 1.000 19.19514 ? 63  ASN A OD1 1 
ATOM   479  N ND2 . ASN A 1 61  ? -39.65110 13.27029  -19.91891 1.000 18.06684 ? 63  ASN A ND2 1 
ATOM   480  N N   . HIS A 1 62  ? -39.81650 7.87032   -18.71058 1.000 14.79469 ? 64  HIS A N   1 
ATOM   481  C CA  . HIS A 1 62  ? -39.73041 6.82807   -17.69233 1.000 16.33298 ? 64  HIS A CA  1 
ATOM   482  C C   . HIS A 1 62  ? -39.23866 5.48749   -18.22595 1.000 16.25097 ? 64  HIS A C   1 
ATOM   483  O O   . HIS A 1 62  ? -39.01622 4.57627   -17.42243 1.000 14.16997 ? 64  HIS A O   1 
ATOM   484  C CB  . HIS A 1 62  ? -41.07558 6.64278   -16.97726 1.000 20.99753 ? 64  HIS A CB  1 
ATOM   485  C CG  . HIS A 1 62  ? -42.23555 6.41849   -17.89333 1.000 20.28080 ? 64  HIS A CG  1 
ATOM   486  N ND1 . HIS A 1 62  ? -42.59730 5.16605   -18.34309 1.000 24.48032 ? 64  HIS A ND1 1 
ATOM   487  C CD2 . HIS A 1 62  ? -43.13979 7.28212   -18.41425 1.000 25.96326 ? 64  HIS A CD2 1 
ATOM   488  C CE1 . HIS A 1 62  ? -43.66676 5.26934   -19.11497 1.000 27.72558 ? 64  HIS A CE1 1 
ATOM   489  N NE2 . HIS A 1 62  ? -44.01864 6.54204   -19.17073 1.000 29.36491 ? 64  HIS A NE2 1 
ATOM   490  N N   . ASN A 1 63  ? -39.03016 5.33830   -19.53785 1.000 13.09207 ? 65  ASN A N   1 
ATOM   491  C CA  . ASN A 1 63  ? -38.38370 4.12571   -20.03095 1.000 12.05615 ? 65  ASN A CA  1 
ATOM   492  C C   . ASN A 1 63  ? -36.88012 4.08760   -19.72047 1.000 13.77916 ? 65  ASN A C   1 
ATOM   493  O O   . ASN A 1 63  ? -36.25938 3.03004   -19.87585 1.000 10.07587 ? 65  ASN A O   1 
ATOM   494  C CB  . ASN A 1 63  ? -38.60346 3.98506   -21.54320 1.000 11.81953 ? 65  ASN A CB  1 
ATOM   495  C CG  . ASN A 1 63  ? -40.08532 3.82832   -21.92015 1.000 19.55719 ? 65  ASN A CG  1 
ATOM   496  O OD1 . ASN A 1 63  ? -40.66229 4.67052   -22.62034 1.000 14.63027 ? 65  ASN A OD1 1 
ATOM   497  N ND2 . ASN A 1 63  ? -40.69850 2.74524   -21.45639 1.000 15.79994 ? 65  ASN A ND2 1 
ATOM   498  N N   . PHE A 1 64  ? -36.29452 5.20949   -19.29005 1.000 12.25501 ? 66  PHE A N   1 
ATOM   499  C CA  . PHE A 1 64  ? -34.86652 5.35428   -19.00941 1.000 10.79084 ? 66  PHE A CA  1 
ATOM   500  C C   . PHE A 1 64  ? -34.64692 5.39956   -17.49848 1.000 14.47721 ? 66  PHE A C   1 
ATOM   501  O O   . PHE A 1 64  ? -35.01860 6.37923   -16.84256 1.000 14.93308 ? 66  PHE A O   1 
ATOM   502  C CB  . PHE A 1 64  ? -34.32714 6.62704   -19.65200 1.000 6.76113  ? 66  PHE A CB  1 
ATOM   503  C CG  . PHE A 1 64  ? -34.31344 6.59323   -21.15627 1.000 10.47162 ? 66  PHE A CG  1 
ATOM   504  C CD1 . PHE A 1 64  ? -33.45512 5.74317   -21.83007 1.000 7.50883  ? 66  PHE A CD1 1 
ATOM   505  C CD2 . PHE A 1 64  ? -35.16272 7.41434   -21.89536 1.000 12.32145 ? 66  PHE A CD2 1 
ATOM   506  C CE1 . PHE A 1 64  ? -33.44043 5.70827   -23.21551 1.000 10.86227 ? 66  PHE A CE1 1 
ATOM   507  C CE2 . PHE A 1 64  ? -35.15791 7.38114   -23.27268 1.000 10.74441 ? 66  PHE A CE2 1 
ATOM   508  C CZ  . PHE A 1 64  ? -34.29756 6.52472   -23.93479 1.000 12.29755 ? 66  PHE A CZ  1 
ATOM   509  N N   . LEU A 1 65  ? -34.02159 4.36208   -16.95345 1.000 14.24560 ? 67  LEU A N   1 
ATOM   510  C CA  . LEU A 1 65  ? -33.65524 4.31063   -15.54153 1.000 14.59232 ? 67  LEU A CA  1 
ATOM   511  C C   . LEU A 1 65  ? -32.18132 4.69880   -15.38132 1.000 15.59279 ? 67  LEU A C   1 
ATOM   512  O O   . LEU A 1 65  ? -31.29351 3.98691   -15.86409 1.000 17.43297 ? 67  LEU A O   1 
ATOM   513  C CB  . LEU A 1 65  ? -33.91957 2.91164   -14.98378 1.000 13.98556 ? 67  LEU A CB  1 
ATOM   514  C CG  . LEU A 1 65  ? -33.36317 2.54147   -13.60245 1.000 22.98426 ? 67  LEU A CG  1 
ATOM   515  C CD1 . LEU A 1 65  ? -33.85012 3.50345   -12.51531 1.000 21.83792 ? 67  LEU A CD1 1 
ATOM   516  C CD2 . LEU A 1 65  ? -33.70105 1.09028   -13.24687 1.000 18.51932 ? 67  LEU A CD2 1 
ATOM   517  N N   . VAL A 1 66  ? -31.92784 5.82800   -14.71570 1.000 12.02831 ? 68  VAL A N   1 
ATOM   518  C CA  . VAL A 1 66  ? -30.58453 6.35367   -14.47286 1.000 11.82424 ? 68  VAL A CA  1 
ATOM   519  C C   . VAL A 1 66  ? -30.30627 6.25992   -12.97803 1.000 17.34605 ? 68  VAL A C   1 
ATOM   520  O O   . VAL A 1 66  ? -31.14815 6.66485   -12.16723 1.000 13.61788 ? 68  VAL A O   1 
ATOM   521  C CB  . VAL A 1 66  ? -30.44555 7.81178   -14.95012 1.000 8.01645  ? 68  VAL A CB  1 
ATOM   522  C CG1 . VAL A 1 66  ? -28.99634 8.31585   -14.75988 1.000 8.60819  ? 68  VAL A CG1 1 
ATOM   523  C CG2 . VAL A 1 66  ? -30.89815 7.96601   -16.39290 1.000 6.68868  ? 68  VAL A CG2 1 
ATOM   524  N N   . GLN A 1 67  ? -29.12555 5.74536   -12.60815 1.000 11.50785 ? 69  GLN A N   1 
ATOM   525  C CA  . GLN A 1 67  ? -28.75547 5.58222   -11.20260 1.000 11.95549 ? 69  GLN A CA  1 
ATOM   526  C C   . GLN A 1 67  ? -27.33769 6.07797   -10.95373 1.000 16.86102 ? 69  GLN A C   1 
ATOM   527  O O   . GLN A 1 67  ? -26.39186 5.59235   -11.58406 1.000 10.02542 ? 69  GLN A O   1 
ATOM   528  C CB  . GLN A 1 67  ? -28.82440 4.12721   -10.75804 1.000 15.08478 ? 69  GLN A CB  1 
ATOM   529  C CG  . GLN A 1 67  ? -30.06393 3.37052   -11.12388 1.000 28.12708 ? 69  GLN A CG  1 
ATOM   530  C CD  . GLN A 1 67  ? -30.11186 2.03898   -10.40112 1.000 37.86699 ? 69  GLN A CD  1 
ATOM   531  O OE1 . GLN A 1 67  ? -30.54387 1.02509   -10.96124 1.000 37.07370 ? 69  GLN A OE1 1 
ATOM   532  N NE2 . GLN A 1 67  ? -29.62931 2.02724   -9.15544  1.000 37.01617 ? 69  GLN A NE2 1 
ATOM   533  N N   . ALA A 1 68  ? -27.18678 7.00536   -10.00057 1.000 17.36210 ? 70  ALA A N   1 
ATOM   534  C CA  . ALA A 1 68  ? -25.88228 7.51062   -9.56926  1.000 21.58993 ? 70  ALA A CA  1 
ATOM   535  C C   . ALA A 1 68  ? -25.62202 6.95171   -8.17242  1.000 22.19767 ? 70  ALA A C   1 
ATOM   536  O O   . ALA A 1 68  ? -26.17451 7.44361   -7.18104  1.000 24.92175 ? 70  ALA A O   1 
ATOM   537  C CB  . ALA A 1 68  ? -25.84170 9.03524   -9.59209  1.000 12.92888 ? 70  ALA A CB  1 
ATOM   538  N N   . GLY A 1 69  ? -24.76771 5.93327   -8.09629  1.000 19.04982 ? 71  GLY A N   1 
ATOM   539  C CA  . GLY A 1 69  ? -24.71759 5.13979   -6.87883  1.000 19.81750 ? 71  GLY A CA  1 
ATOM   540  C C   . GLY A 1 69  ? -26.09704 4.56276   -6.63018  1.000 25.01675 ? 71  GLY A C   1 
ATOM   541  O O   . GLY A 1 69  ? -26.73971 4.03167   -7.54233  1.000 28.70790 ? 71  GLY A O   1 
ATOM   542  N N   . ASN A 1 70  ? -26.58579 4.69725   -5.39781  1.000 29.63828 ? 72  ASN A N   1 
ATOM   543  C CA  . ASN A 1 70  ? -27.91655 4.20988   -5.04538  1.000 30.73073 ? 72  ASN A CA  1 
ATOM   544  C C   . ASN A 1 70  ? -29.03327 5.20233   -5.36910  1.000 29.20773 ? 72  ASN A C   1 
ATOM   545  O O   . ASN A 1 70  ? -30.20967 4.83287   -5.27906  1.000 37.05616 ? 72  ASN A O   1 
ATOM   546  C CB  . ASN A 1 70  ? -27.96814 3.84470   -3.55421  1.000 21.32450 ? 72  ASN A CB  1 
ATOM   547  N N   . VAL A 1 71  ? -28.70666 6.43468   -5.75981  1.000 30.54983 ? 73  VAL A N   1 
ATOM   548  C CA  . VAL A 1 71  ? -29.72166 7.45019   -6.04051  1.000 24.75827 ? 73  VAL A CA  1 
ATOM   549  C C   . VAL A 1 71  ? -30.24952 7.27628   -7.46043  1.000 25.87386 ? 73  VAL A C   1 
ATOM   550  O O   . VAL A 1 71  ? -29.47184 7.20786   -8.42172  1.000 19.51899 ? 73  VAL A O   1 
ATOM   551  C CB  . VAL A 1 71  ? -29.14414 8.86090   -5.84269  1.000 20.29770 ? 73  VAL A CB  1 
ATOM   552  C CG1 . VAL A 1 71  ? -30.26195 9.90273   -5.81517  1.000 20.92802 ? 73  VAL A CG1 1 
ATOM   553  C CG2 . VAL A 1 71  ? -28.30302 8.92122   -4.57596  1.000 22.29298 ? 73  VAL A CG2 1 
ATOM   554  N N   . GLN A 1 72  ? -31.57704 7.22107   -7.60008  1.000 22.65930 ? 74  GLN A N   1 
ATOM   555  C CA  . GLN A 1 72  ? -32.21534 7.19911   -8.90952  1.000 15.78692 ? 74  GLN A CA  1 
ATOM   556  C C   . GLN A 1 72  ? -32.42644 8.63344   -9.37955  1.000 15.08556 ? 74  GLN A C   1 
ATOM   557  O O   . GLN A 1 72  ? -32.94930 9.46589   -8.63557  1.000 25.09879 ? 74  GLN A O   1 
ATOM   558  C CB  . GLN A 1 72  ? -33.54970 6.44455   -8.86463  1.000 15.52976 ? 74  GLN A CB  1 
ATOM   559  N N   . LEU A 1 73  ? -31.99997 8.92557   -10.60029 1.000 12.68588 ? 75  LEU A N   1 
ATOM   560  C CA  . LEU A 1 73  ? -32.15696 10.24427  -11.19540 1.000 14.62746 ? 75  LEU A CA  1 
ATOM   561  C C   . LEU A 1 73  ? -33.39411 10.25019  -12.08106 1.000 19.85089 ? 75  LEU A C   1 
ATOM   562  O O   . LEU A 1 73  ? -33.60023 9.32659   -12.87741 1.000 23.35457 ? 75  LEU A O   1 
ATOM   563  C CB  . LEU A 1 73  ? -30.93356 10.63539  -12.03202 1.000 15.23044 ? 75  LEU A CB  1 
ATOM   564  C CG  . LEU A 1 73  ? -29.55933 10.64717  -11.37311 1.000 13.30132 ? 75  LEU A CG  1 
ATOM   565  C CD1 . LEU A 1 73  ? -28.52384 11.22480  -12.33101 1.000 13.67954 ? 75  LEU A CD1 1 
ATOM   566  C CD2 . LEU A 1 73  ? -29.60438 11.45601  -10.09045 1.000 15.15540 ? 75  LEU A CD2 1 
ATOM   567  N N   . ARG A 1 74  ? -34.21104 11.29557  -11.94232 1.000 14.52166 ? 76  ARG A N   1 
ATOM   568  C CA  . ARG A 1 74  ? -35.44486 11.43284  -12.71339 1.000 18.29167 ? 76  ARG A CA  1 
ATOM   569  C C   . ARG A 1 74  ? -35.09985 12.06340  -14.05418 1.000 12.29541 ? 76  ARG A C   1 
ATOM   570  O O   . ARG A 1 74  ? -34.65075 13.21323  -14.10985 1.000 12.78910 ? 76  ARG A O   1 
ATOM   571  C CB  . ARG A 1 74  ? -36.47500 12.27591  -11.96183 1.000 14.51802 ? 76  ARG A CB  1 
ATOM   572  N N   . VAL A 1 75  ? -35.27224 11.30318  -15.12876 1.000 13.36589 ? 77  VAL A N   1 
ATOM   573  C CA  . VAL A 1 75  ? -35.08469 11.83995  -16.47012 1.000 12.58659 ? 77  VAL A CA  1 
ATOM   574  C C   . VAL A 1 75  ? -36.32668 12.65093  -16.83584 1.000 16.54263 ? 77  VAL A C   1 
ATOM   575  O O   . VAL A 1 75  ? -37.45406 12.16251  -16.71383 1.000 11.42324 ? 77  VAL A O   1 
ATOM   576  C CB  . VAL A 1 75  ? -34.82180 10.70437  -17.47324 1.000 13.25228 ? 77  VAL A CB  1 
ATOM   577  N N   . ILE A 1 76  ? -36.12465 13.90809  -17.23801 1.000 16.52001 ? 78  ILE A N   1 
ATOM   578  C CA  . ILE A 1 76  ? -37.21222 14.82872  -17.56290 1.000 14.09215 ? 78  ILE A CA  1 
ATOM   579  C C   . ILE A 1 76  ? -37.27620 15.15540  -19.04527 1.000 19.67020 ? 78  ILE A C   1 
ATOM   580  O O   . ILE A 1 76  ? -38.17016 15.90194  -19.46560 1.000 16.40658 ? 78  ILE A O   1 
ATOM   581  C CB  . ILE A 1 76  ? -37.10429 16.13107  -16.74721 1.000 16.25027 ? 78  ILE A CB  1 
ATOM   582  C CG1 . ILE A 1 76  ? -35.67755 16.69350  -16.83757 1.000 16.97854 ? 78  ILE A CG1 1 
ATOM   583  C CG2 . ILE A 1 76  ? -37.48989 15.88433  -15.30158 1.000 15.36127 ? 78  ILE A CG2 1 
ATOM   584  C CD1 . ILE A 1 76  ? -35.55819 18.15028  -16.42528 1.000 13.84819 ? 78  ILE A CD1 1 
ATOM   585  N N   . GLY A 1 77  ? -36.35743 14.63213  -19.84465 1.000 17.22541 ? 79  GLY A N   1 
ATOM   586  C CA  . GLY A 1 77  ? -36.31125 14.94005  -21.26138 1.000 14.77884 ? 79  GLY A CA  1 
ATOM   587  C C   . GLY A 1 77  ? -35.21103 14.11970  -21.90183 1.000 13.74151 ? 79  GLY A C   1 
ATOM   588  O O   . GLY A 1 77  ? -34.34263 13.56991  -21.21914 1.000 12.22658 ? 79  GLY A O   1 
ATOM   589  N N   . HIS A 1 78  ? -35.27940 14.02340  -23.22756 1.000 11.47043 ? 80  HIS A N   1 
ATOM   590  C CA  . HIS A 1 78  ? -34.28618 13.24021  -23.94316 1.000 16.39521 ? 80  HIS A CA  1 
ATOM   591  C C   . HIS A 1 78  ? -34.23954 13.69077  -25.39016 1.000 18.41678 ? 80  HIS A C   1 
ATOM   592  O O   . HIS A 1 78  ? -35.23960 14.14798  -25.94587 1.000 14.93431 ? 80  HIS A O   1 
ATOM   593  C CB  . HIS A 1 78  ? -34.57223 11.73309  -23.85775 1.000 14.11093 ? 80  HIS A CB  1 
ATOM   594  C CG  . HIS A 1 78  ? -35.89965 11.31965  -24.42501 1.000 17.52519 ? 80  HIS A CG  1 
ATOM   595  N ND1 . HIS A 1 78  ? -37.01106 11.09321  -23.63728 1.000 21.21610 ? 80  HIS A ND1 1 
ATOM   596  C CD2 . HIS A 1 78  ? -36.28456 11.05262  -25.69725 1.000 20.83024 ? 80  HIS A CD2 1 
ATOM   597  C CE1 . HIS A 1 78  ? -38.02680 10.72251  -24.39890 1.000 17.45988 ? 80  HIS A CE1 1 
ATOM   598  N NE2 . HIS A 1 78  ? -37.61139 10.68586  -25.65287 1.000 18.77441 ? 80  HIS A NE2 1 
ATOM   599  N N   . SER A 1 79  ? -33.05815 13.56659  -25.98618 1.000 13.16654 ? 81  SER A N   1 
ATOM   600  C CA  . SER A 1 79  ? -32.87723 13.81178  -27.40839 1.000 10.71072 ? 81  SER A CA  1 
ATOM   601  C C   . SER A 1 79  ? -31.64602 13.03783  -27.86539 1.000 13.36279 ? 81  SER A C   1 
ATOM   602  O O   . SER A 1 79  ? -30.86003 12.53418  -27.05513 1.000 12.69530 ? 81  SER A O   1 
ATOM   603  C CB  . SER A 1 79  ? -32.75470 15.31361  -27.71582 1.000 13.36267 ? 81  SER A CB  1 
ATOM   604  O OG  . SER A 1 79  ? -31.51194 15.84312  -27.26813 1.000 15.42240 ? 81  SER A OG  1 
ATOM   605  N N   . MET A 1 80  ? -31.48884 12.94618  -29.17579 1.000 10.95369 ? 82  MET A N   1 
ATOM   606  C CA  . MET A 1 80  ? -30.37886 12.24292  -29.79710 1.000 11.45964 ? 82  MET A CA  1 
ATOM   607  C C   . MET A 1 80  ? -29.51973 13.24051  -30.56064 1.000 12.05728 ? 82  MET A C   1 
ATOM   608  O O   . MET A 1 80  ? -30.04810 14.16604  -31.18440 1.000 12.95554 ? 82  MET A O   1 
ATOM   609  C CB  . MET A 1 80  ? -30.90760 11.16173  -30.73635 1.000 12.61451 ? 82  MET A CB  1 
ATOM   610  C CG  . MET A 1 80  ? -29.86277 10.26907  -31.33695 1.000 8.68142  ? 82  MET A CG  1 
ATOM   611  S SD  . MET A 1 80  ? -30.64226 9.03659   -32.38700 1.000 14.38069 ? 82  MET A SD  1 
ATOM   612  C CE  . MET A 1 80  ? -31.12820 7.84623   -31.15726 1.000 11.66228 ? 82  MET A CE  1 
ATOM   613  N N   . GLN A 1 81  ? -28.19601 13.07432  -30.47757 1.000 9.26903  ? 83  GLN A N   1 
ATOM   614  C CA  . GLN A 1 81  ? -27.23636 13.87474  -31.23826 1.000 9.75619  ? 83  GLN A CA  1 
ATOM   615  C C   . GLN A 1 81  ? -26.21166 12.92908  -31.86474 1.000 11.61680 ? 83  GLN A C   1 
ATOM   616  O O   . GLN A 1 81  ? -25.31952 12.42276  -31.17185 1.000 7.96776  ? 83  GLN A O   1 
ATOM   617  C CB  . GLN A 1 81  ? -26.54247 14.92632  -30.37605 1.000 10.56928 ? 83  GLN A CB  1 
ATOM   618  C CG  . GLN A 1 81  ? -25.39953 15.64020  -31.13057 1.000 10.32028 ? 83  GLN A CG  1 
ATOM   619  C CD  . GLN A 1 81  ? -24.68838 16.69270  -30.28327 1.000 16.10065 ? 83  GLN A CD  1 
ATOM   620  O OE1 . GLN A 1 81  ? -24.66650 16.60931  -29.05771 1.000 13.22255 ? 83  GLN A OE1 1 
ATOM   621  N NE2 . GLN A 1 81  ? -24.12028 17.69647  -30.93863 1.000 21.52776 ? 83  GLN A NE2 1 
ATOM   622  N N   . ASN A 1 82  ? -26.33558 12.71159  -33.17721 1.000 6.39192  ? 84  ASN A N   1 
ATOM   623  C CA  . ASN A 1 82  ? -25.54275 11.71025  -33.89786 1.000 9.76584  ? 84  ASN A CA  1 
ATOM   624  C C   . ASN A 1 82  ? -25.74612 10.38092  -33.18499 1.000 6.73731  ? 84  ASN A C   1 
ATOM   625  O O   . ASN A 1 82  ? -26.90308 9.93223   -33.08413 1.000 8.06575  ? 84  ASN A O   1 
ATOM   626  C CB  . ASN A 1 82  ? -24.09177 12.18845  -34.02049 1.000 3.93375  ? 84  ASN A CB  1 
ATOM   627  C CG  . ASN A 1 82  ? -23.99429 13.50445  -34.72367 1.000 5.97938  ? 84  ASN A CG  1 
ATOM   628  O OD1 . ASN A 1 82  ? -24.46757 13.64034  -35.84587 1.000 8.89939  ? 84  ASN A OD1 1 
ATOM   629  N ND2 . ASN A 1 82  ? -23.41593 14.49935  -34.06324 1.000 6.31701  ? 84  ASN A ND2 1 
ATOM   630  N N   . CYS A 1 83  ? -24.70299 9.73837   -32.65278 1.000 4.29607  ? 85  CYS A N   1 
ATOM   631  C CA  . CYS A 1 83  ? -24.85246 8.41625   -32.06403 1.000 4.61897  ? 85  CYS A CA  1 
ATOM   632  C C   . CYS A 1 83  ? -24.84772 8.42791   -30.54092 1.000 3.56100  ? 85  CYS A C   1 
ATOM   633  O O   . CYS A 1 83  ? -24.75233 7.35508   -29.93932 1.000 2.39523  ? 85  CYS A O   1 
ATOM   634  C CB  . CYS A 1 83  ? -23.76483 7.45939   -32.57314 1.000 3.94446  ? 85  CYS A CB  1 
ATOM   635  S SG  . CYS A 1 83  ? -23.81069 7.13962   -34.36084 1.000 6.62320  ? 85  CYS A SG  1 
ATOM   636  N N   . VAL A 1 84  ? -24.95131 9.59735   -29.89818 1.000 3.27965  ? 86  VAL A N   1 
ATOM   637  C CA  . VAL A 1 84  ? -25.09932 9.65595   -28.44434 1.000 4.00143  ? 86  VAL A CA  1 
ATOM   638  C C   . VAL A 1 84  ? -26.49344 10.16700  -28.08362 1.000 5.03444  ? 86  VAL A C   1 
ATOM   639  O O   . VAL A 1 84  ? -27.05350 11.05722  -28.73868 1.000 4.92597  ? 86  VAL A O   1 
ATOM   640  C CB  . VAL A 1 84  ? -24.00834 10.50081  -27.74350 1.000 6.47163  ? 86  VAL A CB  1 
ATOM   641  C CG1 . VAL A 1 84  ? -22.59920 9.92053   -28.01958 1.000 3.53633  ? 86  VAL A CG1 1 
ATOM   642  C CG2 . VAL A 1 84  ? -24.10594 11.97365  -28.13499 1.000 6.99795  ? 86  VAL A CG2 1 
ATOM   643  N N   . LEU A 1 85  ? -27.04771 9.57729   -27.04021 1.000 4.28648  ? 87  LEU A N   1 
ATOM   644  C CA  . LEU A 1 85  ? -28.31364 9.96973   -26.45312 1.000 4.96640  ? 87  LEU A CA  1 
ATOM   645  C C   . LEU A 1 85  ? -28.03279 10.91073  -25.28511 1.000 9.74936  ? 87  LEU A C   1 
ATOM   646  O O   . LEU A 1 85  ? -27.10794 10.67351  -24.49793 1.000 5.90387  ? 87  LEU A O   1 
ATOM   647  C CB  . LEU A 1 85  ? -29.03967 8.70728   -26.00618 1.000 4.22375  ? 87  LEU A CB  1 
ATOM   648  C CG  . LEU A 1 85  ? -30.39696 8.64980   -25.34482 1.000 8.47352  ? 87  LEU A CG  1 
ATOM   649  C CD1 . LEU A 1 85  ? -31.44838 8.80440   -26.40549 1.000 14.36972 ? 87  LEU A CD1 1 
ATOM   650  C CD2 . LEU A 1 85  ? -30.50678 7.28792   -24.68609 1.000 8.20755  ? 87  LEU A CD2 1 
ATOM   651  N N   . LYS A 1 86  ? -28.78560 12.01047  -25.20970 1.000 7.88292  ? 88  LYS A N   1 
ATOM   652  C CA  . LYS A 1 86  ? -28.65767 12.98378  -24.12732 1.000 7.32562  ? 88  LYS A CA  1 
ATOM   653  C C   . LYS A 1 86  ? -29.91915 12.93646  -23.26446 1.000 13.45602 ? 88  LYS A C   1 
ATOM   654  O O   . LYS A 1 86  ? -31.01035 13.30094  -23.72163 1.000 13.10935 ? 88  LYS A O   1 
ATOM   655  C CB  . LYS A 1 86  ? -28.40848 14.38722  -24.67554 1.000 5.35738  ? 88  LYS A CB  1 
ATOM   656  C CG  . LYS A 1 86  ? -26.98171 14.60568  -25.15828 1.000 16.63914 ? 88  LYS A CG  1 
ATOM   657  C CD  . LYS A 1 86  ? -26.92448 15.37169  -26.47646 1.000 16.37155 ? 88  LYS A CD  1 
ATOM   658  C CE  . LYS A 1 86  ? -27.20247 16.85069  -26.28032 1.000 19.27389 ? 88  LYS A CE  1 
ATOM   659  N NZ  . LYS A 1 86  ? -27.05857 17.62297  -27.54360 1.000 20.59240 ? 88  LYS A NZ  1 
ATOM   660  N N   . LEU A 1 87  ? -29.76391 12.49598  -22.01466 1.000 7.40985  ? 89  LEU A N   1 
ATOM   661  C CA  . LEU A 1 87  ? -30.87060 12.37306  -21.07458 1.000 9.39659  ? 89  LEU A CA  1 
ATOM   662  C C   . LEU A 1 87  ? -30.84173 13.56526  -20.12100 1.000 13.03870 ? 89  LEU A C   1 
ATOM   663  O O   . LEU A 1 87  ? -29.92736 13.69591  -19.30137 1.000 7.71052  ? 89  LEU A O   1 
ATOM   664  C CB  . LEU A 1 87  ? -30.80265 11.04712  -20.31382 1.000 6.81842  ? 89  LEU A CB  1 
ATOM   665  C CG  . LEU A 1 87  ? -30.87723 9.76272   -21.14520 1.000 7.56078  ? 89  LEU A CG  1 
ATOM   666  C CD1 . LEU A 1 87  ? -30.88499 8.51446   -20.25795 1.000 4.82352  ? 89  LEU A CD1 1 
ATOM   667  C CD2 . LEU A 1 87  ? -32.10476 9.78050   -22.04690 1.000 12.23201 ? 89  LEU A CD2 1 
ATOM   668  N N   . LYS A 1 88  ? -31.84390 14.43615  -20.22540 1.000 13.86321 ? 90  LYS A N   1 
ATOM   669  C CA  . LYS A 1 88  ? -31.96005 15.54925  -19.29628 1.000 12.64606 ? 90  LYS A CA  1 
ATOM   670  C C   . LYS A 1 88  ? -32.52878 15.03011  -17.98130 1.000 11.08230 ? 90  LYS A C   1 
ATOM   671  O O   . LYS A 1 88  ? -33.51787 14.29014  -17.97469 1.000 13.89908 ? 90  LYS A O   1 
ATOM   672  C CB  . LYS A 1 88  ? -32.83720 16.65539  -19.88528 1.000 12.92310 ? 90  LYS A CB  1 
ATOM   673  C CG  . LYS A 1 88  ? -32.90446 17.89121  -19.01546 1.000 19.39301 ? 90  LYS A CG  1 
ATOM   674  C CD  . LYS A 1 88  ? -33.14127 19.16330  -19.80396 1.000 29.57419 ? 90  LYS A CD  1 
ATOM   675  C CE  . LYS A 1 88  ? -33.68902 20.26504  -18.89092 1.000 32.90645 ? 90  LYS A CE  1 
ATOM   676  N NZ  . LYS A 1 88  ? -33.56784 21.63071  -19.47808 1.000 38.79464 ? 90  LYS A NZ  1 
ATOM   677  N N   . VAL A 1 89  ? -31.86974 15.38120  -16.87360 1.000 12.43961 ? 91  VAL A N   1 
ATOM   678  C CA  . VAL A 1 89  ? -32.23104 14.92550  -15.53737 1.000 13.81504 ? 91  VAL A CA  1 
ATOM   679  C C   . VAL A 1 89  ? -32.54904 16.13874  -14.66985 1.000 14.98685 ? 91  VAL A C   1 
ATOM   680  O O   . VAL A 1 89  ? -32.16804 17.27107  -14.97498 1.000 13.35793 ? 91  VAL A O   1 
ATOM   681  C CB  . VAL A 1 89  ? -31.12764 14.06235  -14.88143 1.000 12.82523 ? 91  VAL A CB  1 
ATOM   682  C CG1 . VAL A 1 89  ? -31.17188 12.63465  -15.42399 1.000 15.29322 ? 91  VAL A CG1 1 
ATOM   683  C CG2 . VAL A 1 89  ? -29.74777 14.67954  -15.09736 1.000 14.06997 ? 91  VAL A CG2 1 
ATOM   684  N N   . ASP A 1 90  ? -33.26060 15.88197  -13.56744 1.000 13.65794 ? 92  ASP A N   1 
ATOM   685  C CA  . ASP A 1 90  ? -33.76459 16.96284  -12.72373 1.000 19.83626 ? 92  ASP A CA  1 
ATOM   686  C C   . ASP A 1 90  ? -32.69117 17.58778  -11.82756 1.000 25.48485 ? 92  ASP A C   1 
ATOM   687  O O   . ASP A 1 90  ? -32.93478 18.66834  -11.26635 1.000 23.60187 ? 92  ASP A O   1 
ATOM   688  C CB  . ASP A 1 90  ? -34.93251 16.47162  -11.84942 1.000 20.27439 ? 92  ASP A CB  1 
ATOM   689  C CG  . ASP A 1 90  ? -34.53885 15.34701  -10.89115 1.000 30.27263 ? 92  ASP A CG  1 
ATOM   690  O OD1 . ASP A 1 90  ? -33.33950 15.02419  -10.74389 1.000 28.88721 ? 92  ASP A OD1 1 
ATOM   691  O OD2 . ASP A 1 90  ? -35.45768 14.79630  -10.24184 1.000 34.35442 ? 92  ASP A OD2 1 
ATOM   692  N N   . THR A 1 91  ? -31.52251 16.94746  -11.67942 1.000 16.34167 ? 93  THR A N   1 
ATOM   693  C CA  . THR A 1 91  ? -30.47323 17.40527  -10.77755 1.000 14.85820 ? 93  THR A CA  1 
ATOM   694  C C   . THR A 1 91  ? -29.19707 17.63545  -11.56479 1.000 13.73982 ? 93  THR A C   1 
ATOM   695  O O   . THR A 1 91  ? -28.76925 16.76188  -12.31671 1.000 12.11575 ? 93  THR A O   1 
ATOM   696  C CB  . THR A 1 91  ? -30.18964 16.37807  -9.67905  1.000 15.30411 ? 93  THR A CB  1 
ATOM   697  O OG1 . THR A 1 91  ? -31.40760 15.94694  -9.05502  1.000 21.34026 ? 93  THR A OG1 1 
ATOM   698  C CG2 . THR A 1 91  ? -29.24455 16.95256  -8.63211  1.000 17.14045 ? 93  THR A CG2 1 
ATOM   699  N N   . ALA A 1 92  ? -28.60010 18.80367  -11.39918 1.000 13.74865 ? 94  ALA A N   1 
ATOM   700  C CA  . ALA A 1 92  ? -27.24500 19.00560  -11.87728 1.000 17.60553 ? 94  ALA A CA  1 
ATOM   701  C C   . ALA A 1 92  ? -26.27405 18.23499  -10.98432 1.000 16.48687 ? 94  ALA A C   1 
ATOM   702  O O   . ALA A 1 92  ? -26.45490 18.17026  -9.76774  1.000 14.89809 ? 94  ALA A O   1 
ATOM   703  C CB  . ALA A 1 92  ? -26.90508 20.49577  -11.88985 1.000 17.64612 ? 94  ALA A CB  1 
ATOM   704  N N   . ASN A 1 93  ? -25.25981 17.61930  -11.59580 1.000 12.89998 ? 95  ASN A N   1 
ATOM   705  C CA  . ASN A 1 93  ? -24.29298 16.82044  -10.83666 1.000 11.71255 ? 95  ASN A CA  1 
ATOM   706  C C   . ASN A 1 93  ? -23.44781 17.75197  -9.98177  1.000 12.34350 ? 95  ASN A C   1 
ATOM   707  O O   . ASN A 1 93  ? -22.78482 18.63828  -10.53041 1.000 13.87822 ? 95  ASN A O   1 
ATOM   708  C CB  . ASN A 1 93  ? -23.41163 16.00603  -11.79448 1.000 15.33799 ? 95  ASN A CB  1 
ATOM   709  C CG  . ASN A 1 93  ? -22.36662 15.13020  -11.07168 1.000 14.51940 ? 95  ASN A CG  1 
ATOM   710  O OD1 . ASN A 1 93  ? -22.36406 15.01087  -9.84678  1.000 17.50003 ? 95  ASN A OD1 1 
ATOM   711  N ND2 . ASN A 1 93  ? -21.47413 14.51482  -11.85092 1.000 9.85005  ? 95  ASN A ND2 1 
ATOM   712  N N   . PRO A 1 94  ? -23.44203 17.61088  -8.65238  1.000 13.96774 ? 96  PRO A N   1 
ATOM   713  C CA  . PRO A 1 94  ? -22.63709 18.53433  -7.83910  1.000 13.25164 ? 96  PRO A CA  1 
ATOM   714  C C   . PRO A 1 94  ? -21.14565 18.33898  -8.04368  1.000 12.84810 ? 96  PRO A C   1 
ATOM   715  O O   . PRO A 1 94  ? -20.37498 19.29452  -7.87991  1.000 14.89477 ? 96  PRO A O   1 
ATOM   716  C CB  . PRO A 1 94  ? -23.07041 18.20651  -6.40384  1.000 17.13245 ? 96  PRO A CB  1 
ATOM   717  C CG  . PRO A 1 94  ? -23.48389 16.77992  -6.46275  1.000 14.38370 ? 96  PRO A CG  1 
ATOM   718  C CD  . PRO A 1 94  ? -24.08594 16.56928  -7.83027  1.000 14.91546 ? 96  PRO A CD  1 
ATOM   719  N N   . LYS A 1 95  ? -20.73038 17.15172  -8.47248  1.000 13.13751 ? 97  LYS A N   1 
ATOM   720  C CA  . LYS A 1 95  ? -19.33747 16.82217  -8.70678  1.000 11.62001 ? 97  LYS A CA  1 
ATOM   721  C C   . LYS A 1 95  ? -18.87015 17.10991  -10.13789 1.000 17.25104 ? 97  LYS A C   1 
ATOM   722  O O   . LYS A 1 95  ? -17.77406 16.66722  -10.51130 1.000 13.06613 ? 97  LYS A O   1 
ATOM   723  C CB  . LYS A 1 95  ? -19.10075 15.34800  -8.35969  1.000 13.30230 ? 97  LYS A CB  1 
ATOM   724  C CG  . LYS A 1 95  ? -19.17027 15.03466  -6.87224  1.000 10.95183 ? 97  LYS A CG  1 
ATOM   725  C CD  . LYS A 1 95  ? -19.10740 13.53526  -6.64343  1.000 14.11319 ? 97  LYS A CD  1 
ATOM   726  C CE  . LYS A 1 95  ? -19.26180 13.18800  -5.17755  1.000 27.49124 ? 97  LYS A CE  1 
ATOM   727  N NZ  . LYS A 1 95  ? -19.65037 11.76076  -4.99247  1.000 34.60078 ? 97  LYS A NZ  1 
ATOM   728  N N   . THR A 1 96  ? -19.65289 17.84573  -10.93611 1.000 12.52602 ? 98  THR A N   1 
ATOM   729  C CA  . THR A 1 96  ? -19.22976 18.16719  -12.29432 1.000 9.69081  ? 98  THR A CA  1 
ATOM   730  C C   . THR A 1 96  ? -17.89457 18.91026  -12.26944 1.000 12.08206 ? 98  THR A C   1 
ATOM   731  O O   . THR A 1 96  ? -17.77006 19.93195  -11.58069 1.000 13.79893 ? 98  THR A O   1 
ATOM   732  C CB  . THR A 1 96  ? -20.27206 19.02008  -13.02377 1.000 13.66068 ? 98  THR A CB  1 
ATOM   733  O OG1 . THR A 1 96  ? -21.52983 18.32722  -13.09067 1.000 13.03558 ? 98  THR A OG1 1 
ATOM   734  C CG2 . THR A 1 96  ? -19.79825 19.33680  -14.43815 1.000 10.25038 ? 98  THR A CG2 1 
ATOM   735  N N   . PRO A 1 97  ? -16.88511 18.44739  -12.99774 1.000 9.88724  ? 99  PRO A N   1 
ATOM   736  C CA  . PRO A 1 97  ? -15.61650 19.17380  -13.06969 1.000 12.86722 ? 99  PRO A CA  1 
ATOM   737  C C   . PRO A 1 97  ? -15.64272 20.19078  -14.20583 1.000 16.63654 ? 99  PRO A C   1 
ATOM   738  O O   . PRO A 1 97  ? -16.52978 20.17920  -15.06015 1.000 14.04851 ? 99  PRO A O   1 
ATOM   739  C CB  . PRO A 1 97  ? -14.59896 18.06277  -13.35535 1.000 9.40831  ? 99  PRO A CB  1 
ATOM   740  C CG  . PRO A 1 97  ? -15.38681 17.07869  -14.19543 1.000 9.12069  ? 99  PRO A CG  1 
ATOM   741  C CD  . PRO A 1 97  ? -16.82157 17.14339  -13.68610 1.000 8.97399  ? 99  PRO A CD  1 
ATOM   742  N N   . LYS A 1 98  ? -14.65555 21.08622  -14.19020 1.000 11.64894 ? 100 LYS A N   1 
ATOM   743  C CA  . LYS A 1 98  ? -14.41066 21.89357  -15.37489 1.000 16.20474 ? 100 LYS A CA  1 
ATOM   744  C C   . LYS A 1 98  ? -14.08781 20.94474  -16.51485 1.000 13.90641 ? 100 LYS A C   1 
ATOM   745  O O   . LYS A 1 98  ? -13.26014 20.04085  -16.36084 1.000 12.49452 ? 100 LYS A O   1 
ATOM   746  C CB  . LYS A 1 98  ? -13.26055 22.87750  -15.14609 1.000 18.74184 ? 100 LYS A CB  1 
ATOM   747  N N   . TYR A 1 99  ? -14.78114 21.10456  -17.63872 1.000 12.01800 ? 101 TYR A N   1 
ATOM   748  C CA  . TYR A 1 99  ? -14.63435 20.14379  -18.72132 1.000 12.16356 ? 101 TYR A CA  1 
ATOM   749  C C   . TYR A 1 99  ? -14.78329 20.83811  -20.06311 1.000 13.24036 ? 101 TYR A C   1 
ATOM   750  O O   . TYR A 1 99  ? -15.22157 21.98615  -20.15236 1.000 17.61069 ? 101 TYR A O   1 
ATOM   751  C CB  . TYR A 1 99  ? -15.64426 18.99429  -18.60051 1.000 12.13226 ? 101 TYR A CB  1 
ATOM   752  C CG  . TYR A 1 99  ? -17.08864 19.34392  -18.97390 1.000 13.27776 ? 101 TYR A CG  1 
ATOM   753  C CD1 . TYR A 1 99  ? -17.53919 19.23648  -20.28805 1.000 11.05614 ? 101 TYR A CD1 1 
ATOM   754  C CD2 . TYR A 1 99  ? -17.99510 19.76863  -18.00309 1.000 11.76900 ? 101 TYR A CD2 1 
ATOM   755  C CE1 . TYR A 1 99  ? -18.85939 19.55573  -20.62472 1.000 7.74441  ? 101 TYR A CE1 1 
ATOM   756  C CE2 . TYR A 1 99  ? -19.31318 20.08339  -18.32750 1.000 11.58978 ? 101 TYR A CE2 1 
ATOM   757  C CZ  . TYR A 1 99  ? -19.73229 19.97532  -19.64233 1.000 12.92327 ? 101 TYR A CZ  1 
ATOM   758  O OH  . TYR A 1 99  ? -21.02901 20.28003  -19.97468 1.000 14.80029 ? 101 TYR A OH  1 
ATOM   759  N N   . LYS A 1 100 ? -14.39199 20.11831  -21.11162 1.000 14.51334 ? 102 LYS A N   1 
ATOM   760  C CA  . LYS A 1 100 ? -14.73654 20.47052  -22.47866 1.000 12.41803 ? 102 LYS A CA  1 
ATOM   761  C C   . LYS A 1 100 ? -14.74255 19.18793  -23.29803 1.000 14.48712 ? 102 LYS A C   1 
ATOM   762  O O   . LYS A 1 100 ? -14.25199 18.14836  -22.85043 1.000 11.04503 ? 102 LYS A O   1 
ATOM   763  C CB  . LYS A 1 100 ? -13.78178 21.52051  -23.06275 1.000 12.28831 ? 102 LYS A CB  1 
ATOM   764  C CG  . LYS A 1 100 ? -12.38713 21.04023  -23.33064 1.000 14.72136 ? 102 LYS A CG  1 
ATOM   765  C CD  . LYS A 1 100 ? -11.44867 22.22033  -23.54797 1.000 21.64758 ? 102 LYS A CD  1 
ATOM   766  C CE  . LYS A 1 100 ? -10.01627 21.75438  -23.80034 1.000 24.88517 ? 102 LYS A CE  1 
ATOM   767  N NZ  . LYS A 1 100 ? -9.03691  22.82592  -23.50241 1.000 31.50766 ? 102 LYS A NZ  1 
ATOM   768  N N   . PHE A 1 101 ? -15.34943 19.26291  -24.48434 1.000 14.08114 ? 103 PHE A N   1 
ATOM   769  C CA  . PHE A 1 101 ? -15.41253 18.15957  -25.43711 1.000 11.36124 ? 103 PHE A CA  1 
ATOM   770  C C   . PHE A 1 101 ? -14.45684 18.45604  -26.58125 1.000 10.38920 ? 103 PHE A C   1 
ATOM   771  O O   . PHE A 1 101 ? -14.47896 19.55507  -27.13820 1.000 18.54381 ? 103 PHE A O   1 
ATOM   772  C CB  . PHE A 1 101 ? -16.82851 17.96423  -26.00283 1.000 10.63403 ? 103 PHE A CB  1 
ATOM   773  C CG  . PHE A 1 101 ? -17.86118 17.54716  -24.98852 1.000 8.55610  ? 103 PHE A CG  1 
ATOM   774  C CD1 . PHE A 1 101 ? -17.49682 16.97885  -23.77743 1.000 8.03453  ? 103 PHE A CD1 1 
ATOM   775  C CD2 . PHE A 1 101 ? -19.22119 17.71868  -25.26063 1.000 9.22061  ? 103 PHE A CD2 1 
ATOM   776  C CE1 . PHE A 1 101 ? -18.47291 16.59690  -22.85409 1.000 6.27809  ? 103 PHE A CE1 1 
ATOM   777  C CE2 . PHE A 1 101 ? -20.19653 17.33770  -24.33862 1.000 10.47739 ? 103 PHE A CE2 1 
ATOM   778  C CZ  . PHE A 1 101 ? -19.82000 16.78070  -23.13562 1.000 6.41717  ? 103 PHE A CZ  1 
ATOM   779  N N   . VAL A 1 102 ? -13.62130 17.48051  -26.92542 1.000 6.96673  ? 104 VAL A N   1 
ATOM   780  C CA  . VAL A 1 102 ? -12.62247 17.60596  -27.97804 1.000 8.87986  ? 104 VAL A CA  1 
ATOM   781  C C   . VAL A 1 102 ? -12.70268 16.36637  -28.86128 1.000 7.85550  ? 104 VAL A C   1 
ATOM   782  O O   . VAL A 1 102 ? -12.96963 15.26227  -28.38258 1.000 10.47805 ? 104 VAL A O   1 
ATOM   783  C CB  . VAL A 1 102 ? -11.18830 17.76539  -27.38509 1.000 9.06986  ? 104 VAL A CB  1 
ATOM   784  C CG1 . VAL A 1 102 ? -10.15511 17.99067  -28.47032 1.000 13.67320 ? 104 VAL A CG1 1 
ATOM   785  C CG2 . VAL A 1 102 ? -11.14099 18.89520  -26.36635 1.000 12.88618 ? 104 VAL A CG2 1 
ATOM   786  N N   . ARG A 1 103 ? -12.45977 16.54165  -30.15369 1.000 9.05894  ? 105 ARG A N   1 
ATOM   787  C CA  . ARG A 1 103 ? -12.25236 15.42380  -31.06664 1.000 9.91787  ? 105 ARG A CA  1 
ATOM   788  C C   . ARG A 1 103 ? -10.76059 15.34091  -31.35513 1.000 8.13716  ? 105 ARG A C   1 
ATOM   789  O O   . ARG A 1 103 ? -10.15864 16.34945  -31.72283 1.000 11.47985 ? 105 ARG A O   1 
ATOM   790  C CB  . ARG A 1 103 ? -13.03873 15.60890  -32.36794 1.000 6.29746  ? 105 ARG A CB  1 
ATOM   791  C CG  . ARG A 1 103 ? -12.98632 14.40705  -33.31569 1.000 6.74830  ? 105 ARG A CG  1 
ATOM   792  C CD  . ARG A 1 103 ? -13.94431 14.56376  -34.49021 1.000 7.82533  ? 105 ARG A CD  1 
ATOM   793  N NE  . ARG A 1 103 ? -13.87353 13.45069  -35.44610 1.000 11.47269 ? 105 ARG A NE  1 
ATOM   794  C CZ  . ARG A 1 103 ? -14.57659 12.32008  -35.35081 1.000 8.70191  ? 105 ARG A CZ  1 
ATOM   795  N NH1 . ARG A 1 103 ? -15.41369 12.12816  -34.33016 1.000 8.02199  ? 105 ARG A NH1 1 
ATOM   796  N NH2 . ARG A 1 103 ? -14.44772 11.38150  -36.27447 1.000 5.93937  ? 105 ARG A NH2 1 
ATOM   797  N N   . ILE A 1 104 ? -10.17574 14.15887  -31.18561 1.000 6.22452  ? 106 ILE A N   1 
ATOM   798  C CA  . ILE A 1 104 ? -8.72431  13.97013  -31.29113 1.000 10.49070 ? 106 ILE A CA  1 
ATOM   799  C C   . ILE A 1 104 ? -8.37185  13.34992  -32.63786 1.000 8.42584  ? 106 ILE A C   1 
ATOM   800  O O   . ILE A 1 104 ? -9.22210  12.81416  -33.34243 1.000 8.27672  ? 106 ILE A O   1 
ATOM   801  C CB  . ILE A 1 104 ? -8.17634  13.08071  -30.15625 1.000 7.85067  ? 106 ILE A CB  1 
ATOM   802  C CG1 . ILE A 1 104 ? -8.87500  11.71188  -30.20981 1.000 4.74659  ? 106 ILE A CG1 1 
ATOM   803  C CG2 . ILE A 1 104 ? -8.32473  13.77591  -28.80818 1.000 8.80760  ? 106 ILE A CG2 1 
ATOM   804  C CD1 . ILE A 1 104 ? -8.25918  10.67638  -29.33098 1.000 8.61064  ? 106 ILE A CD1 1 
ATOM   805  N N   . GLN A 1 105 ? -7.08798  13.37486  -32.97607 1.000 7.26162  ? 107 GLN A N   1 
ATOM   806  C CA  . GLN A 1 105 ? -6.54725  12.84463  -34.22438 1.000 8.03986  ? 107 GLN A CA  1 
ATOM   807  C C   . GLN A 1 105 ? -5.75567  11.55582  -33.99215 1.000 3.78340  ? 107 GLN A C   1 
ATOM   808  O O   . GLN A 1 105 ? -5.33405  11.27137  -32.86922 1.000 2.43949  ? 107 GLN A O   1 
ATOM   809  C CB  . GLN A 1 105 ? -5.64265  13.88893  -34.88883 1.000 10.28499 ? 107 GLN A CB  1 
ATOM   810  C CG  . GLN A 1 105 ? -6.34840  15.18336  -35.24675 1.000 13.64974 ? 107 GLN A CG  1 
ATOM   811  C CD  . GLN A 1 105 ? -7.63027  14.94997  -36.02588 1.000 20.41686 ? 107 GLN A CD  1 
ATOM   812  O OE1 . GLN A 1 105 ? -7.65501  14.17808  -36.98127 1.000 22.09178 ? 107 GLN A OE1 1 
ATOM   813  N NE2 . GLN A 1 105 ? -8.70979  15.60783  -35.60713 1.000 17.26038 ? 107 GLN A NE2 1 
ATOM   814  N N   . PRO A 1 106 ? -5.58272  10.72874  -35.02420 1.000 7.31514  ? 108 PRO A N   1 
ATOM   815  C CA  . PRO A 1 106 ? -4.70225  9.55321   -34.90442 1.000 7.68160  ? 108 PRO A CA  1 
ATOM   816  C C   . PRO A 1 106 ? -3.34874  9.90368   -34.30173 1.000 6.35389  ? 108 PRO A C   1 
ATOM   817  O O   . PRO A 1 106 ? -2.73916  10.90898  -34.65414 1.000 5.71252  ? 108 PRO A O   1 
ATOM   818  C CB  . PRO A 1 106 ? -4.55983  9.08323   -36.35265 1.000 6.11350  ? 108 PRO A CB  1 
ATOM   819  C CG  . PRO A 1 106 ? -5.90193  9.46417   -36.96435 1.000 5.49206  ? 108 PRO A CG  1 
ATOM   820  C CD  . PRO A 1 106 ? -6.31965  10.74374  -36.30365 1.000 2.73462  ? 108 PRO A CD  1 
ATOM   821  N N   . GLY A 1 107 ? -2.89712  9.07613   -33.35275 1.000 6.74922  ? 109 GLY A N   1 
ATOM   822  C CA  . GLY A 1 107 ? -1.65583  9.29555   -32.63909 1.000 6.89304  ? 109 GLY A CA  1 
ATOM   823  C C   . GLY A 1 107 ? -1.82261  9.92357   -31.26922 1.000 7.47477  ? 109 GLY A C   1 
ATOM   824  O O   . GLY A 1 107 ? -0.92802  9.78990   -30.42645 1.000 5.33213  ? 109 GLY A O   1 
ATOM   825  N N   . GLN A 1 108 ? -2.94272  10.59907  -31.02779 1.000 6.25839  ? 110 GLN A N   1 
ATOM   826  C CA  . GLN A 1 108 ? -3.19675  11.22579  -29.73590 1.000 4.49725  ? 110 GLN A CA  1 
ATOM   827  C C   . GLN A 1 108 ? -3.44744  10.15257  -28.67650 1.000 4.19347  ? 110 GLN A C   1 
ATOM   828  O O   . GLN A 1 108 ? -3.92509  9.06379   -28.97712 1.000 4.21711  ? 110 GLN A O   1 
ATOM   829  C CB  . GLN A 1 108 ? -4.38835  12.18357  -29.85125 1.000 6.43722  ? 110 GLN A CB  1 
ATOM   830  C CG  . GLN A 1 108 ? -4.67279  12.99952  -28.60418 1.000 6.05115  ? 110 GLN A CG  1 
ATOM   831  C CD  . GLN A 1 108 ? -3.52489  13.93500  -28.23954 1.000 12.01526 ? 110 GLN A CD  1 
ATOM   832  O OE1 . GLN A 1 108 ? -2.71478  13.63035  -27.35120 1.000 6.90911  ? 110 GLN A OE1 1 
ATOM   833  N NE2 . GLN A 1 108 ? -3.44856  15.07598  -28.92274 1.000 7.52122  ? 110 GLN A NE2 1 
ATOM   834  N N   . THR A 1 109 ? -3.04961  10.44136  -27.44044 1.000 7.13168  ? 111 THR A N   1 
ATOM   835  C CA  . THR A 1 109 ? -3.25395  9.53829   -26.31874 1.000 5.42434  ? 111 THR A CA  1 
ATOM   836  C C   . THR A 1 109 ? -4.28666  10.10491  -25.34821 1.000 5.17929  ? 111 THR A C   1 
ATOM   837  O O   . THR A 1 109 ? -4.62371  11.29248  -25.38171 1.000 4.27253  ? 111 THR A O   1 
ATOM   838  C CB  . THR A 1 109 ? -1.92687  9.27258   -25.58551 1.000 6.61706  ? 111 THR A CB  1 
ATOM   839  O OG1 . THR A 1 109 ? -1.31822  10.51757  -25.23013 1.000 2.70358  ? 111 THR A OG1 1 
ATOM   840  C CG2 . THR A 1 109 ? -0.98483  8.48354   -26.48097 1.000 5.65649  ? 111 THR A CG2 1 
ATOM   841  N N   . PHE A 1 110 ? -4.77992  9.23561   -24.46815 1.000 3.38023  ? 112 PHE A N   1 
ATOM   842  C CA  . PHE A 1 110 ? -5.72977  9.63710   -23.43995 1.000 6.21257  ? 112 PHE A CA  1 
ATOM   843  C C   . PHE A 1 110 ? -5.84614  8.51329   -22.41961 1.000 4.46280  ? 112 PHE A C   1 
ATOM   844  O O   . PHE A 1 110 ? -5.44934  7.37634   -22.68430 1.000 4.55291  ? 112 PHE A O   1 
ATOM   845  C CB  . PHE A 1 110 ? -7.10971  9.96529   -24.03707 1.000 3.61255  ? 112 PHE A CB  1 
ATOM   846  C CG  . PHE A 1 110 ? -7.63886  8.89428   -24.96589 1.000 4.98203  ? 112 PHE A CG  1 
ATOM   847  C CD1 . PHE A 1 110 ? -7.29599  8.88352   -26.30772 1.000 4.35567  ? 112 PHE A CD1 1 
ATOM   848  C CD2 . PHE A 1 110 ? -8.47839  7.90273   -24.49277 1.000 6.06221  ? 112 PHE A CD2 1 
ATOM   849  C CE1 . PHE A 1 110 ? -7.76759  7.89644   -27.16043 1.000 7.66634  ? 112 PHE A CE1 1 
ATOM   850  C CE2 . PHE A 1 110 ? -8.98097  6.91457   -25.35179 1.000 7.34711  ? 112 PHE A CE2 1 
ATOM   851  C CZ  . PHE A 1 110 ? -8.62612  6.91424   -26.68314 1.000 9.66301  ? 112 PHE A CZ  1 
ATOM   852  N N   . SER A 1 111 ? -6.39957  8.84431   -21.25132 1.000 2.65416  ? 113 SER A N   1 
ATOM   853  C CA  . SER A 1 111 ? -6.71694  7.84187   -20.23726 1.000 4.75653  ? 113 SER A CA  1 
ATOM   854  C C   . SER A 1 111 ? -8.13017  7.29513   -20.43180 1.000 3.74275  ? 113 SER A C   1 
ATOM   855  O O   . SER A 1 111 ? -9.03864  8.01740   -20.84312 1.000 4.62671  ? 113 SER A O   1 
ATOM   856  C CB  . SER A 1 111 ? -6.58213  8.43310   -18.83061 1.000 5.97611  ? 113 SER A CB  1 
ATOM   857  O OG  . SER A 1 111 ? -5.26519  8.92304   -18.63030 1.000 6.73114  ? 113 SER A OG  1 
ATOM   858  N N   . VAL A 1 112 ? -8.32433  6.01655   -20.10927 1.000 4.28642  ? 114 VAL A N   1 
ATOM   859  C CA  . VAL A 1 112 ? -9.64912  5.39836   -20.14628 1.000 1.82330  ? 114 VAL A CA  1 
ATOM   860  C C   . VAL A 1 112 ? -9.99655  4.89438   -18.75654 1.000 4.17363  ? 114 VAL A C   1 
ATOM   861  O O   . VAL A 1 112 ? -9.21614  4.15321   -18.15156 1.000 2.82415  ? 114 VAL A O   1 
ATOM   862  C CB  . VAL A 1 112 ? -9.71434  4.23515   -21.15027 1.000 3.94010  ? 114 VAL A CB  1 
ATOM   863  C CG1 . VAL A 1 112 ? -11.04419 3.49283   -21.00438 1.000 1.63103  ? 114 VAL A CG1 1 
ATOM   864  C CG2 . VAL A 1 112 ? -9.51460  4.73865   -22.56039 1.000 4.26213  ? 114 VAL A CG2 1 
ATOM   865  N N   . LEU A 1 113 ? -11.17543 5.27108   -18.26339 1.000 2.87269  ? 115 LEU A N   1 
ATOM   866  C CA  . LEU A 1 113 ? -11.72005 4.71057   -17.03034 1.000 2.81872  ? 115 LEU A CA  1 
ATOM   867  C C   . LEU A 1 113 ? -12.73964 3.64198   -17.42229 1.000 5.17974  ? 115 LEU A C   1 
ATOM   868  O O   . LEU A 1 113 ? -13.88518 3.95504   -17.74859 1.000 5.40892  ? 115 LEU A O   1 
ATOM   869  C CB  . LEU A 1 113 ? -12.33927 5.80169   -16.16179 1.000 1.70727  ? 115 LEU A CB  1 
ATOM   870  C CG  . LEU A 1 113 ? -12.95591 5.34816   -14.82683 1.000 5.14772  ? 115 LEU A CG  1 
ATOM   871  C CD1 . LEU A 1 113 ? -11.91638 4.76523   -13.88309 1.000 3.07588  ? 115 LEU A CD1 1 
ATOM   872  C CD2 . LEU A 1 113 ? -13.69560 6.50412   -14.16645 1.000 3.56533  ? 115 LEU A CD2 1 
ATOM   873  N N   . ALA A 1 114 ? -12.32357 2.37697   -17.39100 1.000 3.53718  ? 116 ALA A N   1 
ATOM   874  C CA  . ALA A 1 114 ? -13.24488 1.28710   -17.67042 1.000 3.37992  ? 116 ALA A CA  1 
ATOM   875  C C   . ALA A 1 114 ? -14.23359 1.12238   -16.51859 1.000 6.95552  ? 116 ALA A C   1 
ATOM   876  O O   . ALA A 1 114 ? -13.83676 1.03311   -15.34934 1.000 5.19764  ? 116 ALA A O   1 
ATOM   877  C CB  . ALA A 1 114 ? -12.49418 -0.02015  -17.91102 1.000 2.46000  ? 116 ALA A CB  1 
ATOM   878  N N   . CYS A 1 115 ? -15.52293 1.05959   -16.86231 1.000 5.02874  ? 117 CYS A N   1 
ATOM   879  C CA  . CYS A 1 115 ? -16.61515 1.00820   -15.89891 1.000 5.11582  ? 117 CYS A CA  1 
ATOM   880  C C   . CYS A 1 115 ? -17.63844 -0.04092  -16.31169 1.000 6.21767  ? 117 CYS A C   1 
ATOM   881  O O   . CYS A 1 115 ? -17.78283 -0.36400  -17.49302 1.000 5.50766  ? 117 CYS A O   1 
ATOM   882  C CB  . CYS A 1 115 ? -17.33982 2.34460   -15.76757 1.000 6.87576  ? 117 CYS A CB  1 
ATOM   883  S SG  . CYS A 1 115 ? -16.35006 3.74953   -15.30863 1.000 5.55666  ? 117 CYS A SG  1 
ATOM   884  N N   . TYR A 1 116 ? -18.34343 -0.57644  -15.31297 1.000 8.08874  ? 118 TYR A N   1 
ATOM   885  C CA  . TYR A 1 116 ? -19.40097 -1.55873  -15.52506 1.000 6.60320  ? 118 TYR A CA  1 
ATOM   886  C C   . TYR A 1 116 ? -20.51964 -1.25487  -14.53727 1.000 6.24112  ? 118 TYR A C   1 
ATOM   887  O O   . TYR A 1 116 ? -20.25728 -1.02417  -13.35655 1.000 4.97084  ? 118 TYR A O   1 
ATOM   888  C CB  . TYR A 1 116 ? -18.87030 -2.99793  -15.36844 1.000 10.40993 ? 118 TYR A CB  1 
ATOM   889  C CG  . TYR A 1 116 ? -17.73971 -3.32255  -16.36367 1.000 13.01345 ? 118 TYR A CG  1 
ATOM   890  C CD1 . TYR A 1 116 ? -18.02218 -3.75835  -17.66253 1.000 6.58446  ? 118 TYR A CD1 1 
ATOM   891  C CD2 . TYR A 1 116 ? -16.40597 -3.14914  -16.01563 1.000 9.08601  ? 118 TYR A CD2 1 
ATOM   892  C CE1 . TYR A 1 116 ? -17.01573 -4.02208  -18.57500 1.000 5.83318  ? 118 TYR A CE1 1 
ATOM   893  C CE2 . TYR A 1 116 ? -15.38191 -3.41468  -16.92859 1.000 9.40681  ? 118 TYR A CE2 1 
ATOM   894  C CZ  . TYR A 1 116 ? -15.69755 -3.84760  -18.20398 1.000 9.82239  ? 118 TYR A CZ  1 
ATOM   895  O OH  . TYR A 1 116 ? -14.69638 -4.10542  -19.11590 1.000 10.63345 ? 118 TYR A OH  1 
ATOM   896  N N   . ASN A 1 117 ? -21.76216 -1.21324  -15.03165 1.000 13.13737 ? 119 ASN A N   1 
ATOM   897  C CA  . ASN A 1 117 ? -22.92456 -0.89527  -14.19285 1.000 9.26941  ? 119 ASN A CA  1 
ATOM   898  C C   . ASN A 1 117 ? -22.75206 0.45657   -13.51351 1.000 10.83140 ? 119 ASN A C   1 
ATOM   899  O O   . ASN A 1 117 ? -23.05641 0.61148   -12.33398 1.000 5.29480  ? 119 ASN A O   1 
ATOM   900  C CB  . ASN A 1 117 ? -23.16587 -1.98379  -13.14969 1.000 6.68171  ? 119 ASN A CB  1 
ATOM   901  C CG  . ASN A 1 117 ? -23.20378 -3.35827  -13.75815 1.000 12.31004 ? 119 ASN A CG  1 
ATOM   902  O OD1 . ASN A 1 117 ? -23.99906 -3.62335  -14.64329 1.000 21.15066 ? 119 ASN A OD1 1 
ATOM   903  N ND2 . ASN A 1 117 ? -22.32923 -4.23962  -13.29727 1.000 23.44090 ? 119 ASN A ND2 1 
ATOM   904  N N   . GLY A 1 118 ? -22.20620 1.42554   -14.25407 1.000 9.64391  ? 120 GLY A N   1 
ATOM   905  C CA  . GLY A 1 118 ? -21.91684 2.73774   -13.71872 1.000 9.12504  ? 120 GLY A CA  1 
ATOM   906  C C   . GLY A 1 118 ? -20.83159 2.79732   -12.65915 1.000 10.71963 ? 120 GLY A C   1 
ATOM   907  O O   . GLY A 1 118 ? -20.63719 3.85782   -12.06056 1.000 11.43391 ? 120 GLY A O   1 
ATOM   908  N N   . SER A 1 119 ? -20.10451 1.70880   -12.40338 1.000 8.31927  ? 121 SER A N   1 
ATOM   909  C CA  . SER A 1 119 ? -19.08326 1.80082   -11.37195 1.000 11.68791 ? 121 SER A CA  1 
ATOM   910  C C   . SER A 1 119 ? -17.68178 1.60512   -11.94475 1.000 9.56408  ? 121 SER A C   1 
ATOM   911  O O   . SER A 1 119 ? -17.42666 0.63394   -12.67189 1.000 8.25488  ? 121 SER A O   1 
ATOM   912  C CB  . SER A 1 119 ? -19.34614 0.78420   -10.24869 1.000 11.28116 ? 121 SER A CB  1 
ATOM   913  O OG  . SER A 1 119 ? -19.38831 -0.52980  -10.76326 1.000 23.42115 ? 121 SER A OG  1 
ATOM   914  N N   . PRO A 1 120 ? -16.75450 2.49822   -11.60303 1.000 11.14998 ? 122 PRO A N   1 
ATOM   915  C CA  . PRO A 1 120 ? -15.41247 2.46443   -12.21257 1.000 9.79781  ? 122 PRO A CA  1 
ATOM   916  C C   . PRO A 1 120 ? -14.58663 1.25613   -11.78790 1.000 7.94674  ? 122 PRO A C   1 
ATOM   917  O O   . PRO A 1 120 ? -14.51281 0.90455   -10.60958 1.000 11.18985 ? 122 PRO A O   1 
ATOM   918  C CB  . PRO A 1 120 ? -14.77348 3.77281   -11.73364 1.000 8.28975  ? 122 PRO A CB  1 
ATOM   919  C CG  . PRO A 1 120 ? -15.59314 4.22840   -10.58996 1.000 15.33873 ? 122 PRO A CG  1 
ATOM   920  C CD  . PRO A 1 120 ? -16.98517 3.72263   -10.81467 1.000 10.87763 ? 122 PRO A CD  1 
ATOM   921  N N   . SER A 1 121 ? -13.94703 0.63575   -12.77252 1.000 6.07762  ? 123 SER A N   1 
ATOM   922  C CA  . SER A 1 121 ? -13.22096 -0.61940  -12.61908 1.000 7.36803  ? 123 SER A CA  1 
ATOM   923  C C   . SER A 1 121 ? -11.69493 -0.49354  -12.72219 1.000 7.70867  ? 123 SER A C   1 
ATOM   924  O O   . SER A 1 121 ? -10.97693 -1.19397  -12.00616 1.000 6.31496  ? 123 SER A O   1 
ATOM   925  C CB  . SER A 1 121 ? -13.72722 -1.60774  -13.66662 1.000 6.07663  ? 123 SER A CB  1 
ATOM   926  O OG  . SER A 1 121 ? -13.03808 -2.83732  -13.60309 1.000 15.55406 ? 123 SER A OG  1 
ATOM   927  N N   . GLY A 1 122 ? -11.16966 0.37032   -13.58602 1.000 4.35536  ? 124 GLY A N   1 
ATOM   928  C CA  . GLY A 1 122 ? -9.73083  0.50443   -13.76674 1.000 5.35924  ? 124 GLY A CA  1 
ATOM   929  C C   . GLY A 1 122 ? -9.44407  1.64663   -14.71660 1.000 6.49535  ? 124 GLY A C   1 
ATOM   930  O O   . GLY A 1 122 ? -10.33859 2.11695   -15.43329 1.000 8.00350  ? 124 GLY A O   1 
ATOM   931  N N   . VAL A 1 123 ? -8.18701  2.09516   -14.71168 1.000 5.49862  ? 125 VAL A N   1 
ATOM   932  C CA  . VAL A 1 123 ? -7.75488  3.24452   -15.50708 1.000 3.79087  ? 125 VAL A CA  1 
ATOM   933  C C   . VAL A 1 123 ? -6.45885  2.88001   -16.21674 1.000 5.87187  ? 125 VAL A C   1 
ATOM   934  O O   . VAL A 1 123 ? -5.53965  2.32941   -15.60241 1.000 5.46313  ? 125 VAL A O   1 
ATOM   935  C CB  . VAL A 1 123 ? -7.59129  4.52115   -14.64216 1.000 2.94584  ? 125 VAL A CB  1 
ATOM   936  C CG1 . VAL A 1 123 ? -6.58796  4.32980   -13.55769 1.000 7.45578  ? 125 VAL A CG1 1 
ATOM   937  C CG2 . VAL A 1 123 ? -7.20956  5.73442   -15.48108 1.000 3.31127  ? 125 VAL A CG2 1 
ATOM   938  N N   . TYR A 1 124 ? -6.39836  3.14932   -17.51781 1.000 4.15067  ? 126 TYR A N   1 
ATOM   939  C CA  . TYR A 1 124 ? -5.19680  2.86105   -18.28119 1.000 7.41587  ? 126 TYR A CA  1 
ATOM   940  C C   . TYR A 1 124 ? -5.07088  3.89062   -19.38785 1.000 8.32037  ? 126 TYR A C   1 
ATOM   941  O O   . TYR A 1 124 ? -6.00932  4.62626   -19.70053 1.000 2.29673  ? 126 TYR A O   1 
ATOM   942  C CB  . TYR A 1 124 ? -5.19630  1.43668   -18.85889 1.000 7.19159  ? 126 TYR A CB  1 
ATOM   943  C CG  . TYR A 1 124 ? -6.44432  1.08539   -19.65337 1.000 8.41983  ? 126 TYR A CG  1 
ATOM   944  C CD1 . TYR A 1 124 ? -7.56792  0.55235   -19.02290 1.000 6.16105  ? 126 TYR A CD1 1 
ATOM   945  C CD2 . TYR A 1 124 ? -6.49583  1.28803   -21.02626 1.000 5.48347  ? 126 TYR A CD2 1 
ATOM   946  C CE1 . TYR A 1 124 ? -8.70369  0.22518   -19.74140 1.000 6.93158  ? 126 TYR A CE1 1 
ATOM   947  C CE2 . TYR A 1 124 ? -7.62677  0.96955   -21.75017 1.000 9.61098  ? 126 TYR A CE2 1 
ATOM   948  C CZ  . TYR A 1 124 ? -8.73449  0.44762   -21.10107 1.000 5.13359  ? 126 TYR A CZ  1 
ATOM   949  O OH  . TYR A 1 124 ? -9.85937  0.12799   -21.82605 1.000 10.32766 ? 126 TYR A OH  1 
ATOM   950  N N   . GLN A 1 125 ? -3.87753  3.94644   -19.95631 1.000 5.74752  ? 127 GLN A N   1 
ATOM   951  C CA  . GLN A 1 125 ? -3.55622  4.86568   -21.02608 1.000 5.28805  ? 127 GLN A CA  1 
ATOM   952  C C   . GLN A 1 125 ? -3.75029  4.15909   -22.36631 1.000 8.50931  ? 127 GLN A C   1 
ATOM   953  O O   . GLN A 1 125 ? -3.54020  2.95005   -22.48132 1.000 10.14155 ? 127 GLN A O   1 
ATOM   954  C CB  . GLN A 1 125 ? -2.12108  5.35833   -20.84464 1.000 10.62892 ? 127 GLN A CB  1 
ATOM   955  C CG  . GLN A 1 125 ? -1.73220  6.48876   -21.73763 1.000 15.25135 ? 127 GLN A CG  1 
ATOM   956  C CD  . GLN A 1 125 ? -2.22557  7.84333   -21.25100 1.000 15.36792 ? 127 GLN A CD  1 
ATOM   957  O OE1 . GLN A 1 125 ? -3.17683  7.95180   -20.45312 1.000 14.76752 ? 127 GLN A OE1 1 
ATOM   958  N NE2 . GLN A 1 125 ? -1.58965  8.89544   -21.75328 1.000 16.05148 ? 127 GLN A NE2 1 
ATOM   959  N N   . CYS A 1 126 ? -4.20022  4.91721   -23.36926 1.000 7.37744  ? 128 CYS A N   1 
ATOM   960  C CA  . CYS A 1 126 ? -4.63268  4.37045   -24.65022 1.000 8.86001  ? 128 CYS A CA  1 
ATOM   961  C C   . CYS A 1 126 ? -4.24717  5.36046   -25.74413 1.000 8.96467  ? 128 CYS A C   1 
ATOM   962  O O   . CYS A 1 126 ? -3.77084  6.46097   -25.46097 1.000 8.63863  ? 128 CYS A O   1 
ATOM   963  C CB  . CYS A 1 126 ? -6.15293  4.14445   -24.65055 1.000 9.89805  ? 128 CYS A CB  1 
ATOM   964  S SG  . CYS A 1 126 ? -6.70377  2.75387   -25.57948 1.000 28.53124 ? 128 CYS A SG  1 
ATOM   965  N N   . ALA A 1 127 ? -4.50969  4.99635   -27.00186 1.000 8.92246  ? 129 ALA A N   1 
ATOM   966  C CA  . ALA A 1 127 ? -4.18210  5.88416   -28.11360 1.000 7.66850  ? 129 ALA A CA  1 
ATOM   967  C C   . ALA A 1 127 ? -5.11634  5.63430   -29.28814 1.000 4.85380  ? 129 ALA A C   1 
ATOM   968  O O   . ALA A 1 127 ? -5.55834  4.50826   -29.52294 1.000 5.43301  ? 129 ALA A O   1 
ATOM   969  C CB  . ALA A 1 127 ? -2.72793  5.71364   -28.58069 1.000 5.17675  ? 129 ALA A CB  1 
ATOM   970  N N   . MET A 1 128 ? -5.38401  6.69622   -30.03852 1.000 4.77950  ? 130 MET A N   1 
ATOM   971  C CA  . MET A 1 128 ? -6.18275  6.60076   -31.26040 1.000 6.37171  ? 130 MET A CA  1 
ATOM   972  C C   . MET A 1 128 ? -5.28531  6.12706   -32.40747 1.000 6.17384  ? 130 MET A C   1 
ATOM   973  O O   . MET A 1 128 ? -4.30279  6.79868   -32.75793 1.000 7.32981  ? 130 MET A O   1 
ATOM   974  C CB  . MET A 1 128 ? -6.83205  7.95722   -31.55581 1.000 5.29434  ? 130 MET A CB  1 
ATOM   975  C CG  . MET A 1 128 ? -7.73086  8.06280   -32.80722 1.000 3.98320  ? 130 MET A CG  1 
ATOM   976  S SD  . MET A 1 128 ? -9.14760  6.97053   -32.75262 1.000 6.86395  ? 130 MET A SD  1 
ATOM   977  C CE  . MET A 1 128 ? -10.00213 7.58268   -31.28326 1.000 6.33679  ? 130 MET A CE  1 
ATOM   978  N N   . ARG A 1 129 ? -5.59517  4.95265   -32.96529 1.000 8.67281  ? 131 ARG A N   1 
ATOM   979  C CA  . ARG A 1 129 ? -4.81958  4.39285   -34.06949 1.000 6.85288  ? 131 ARG A CA  1 
ATOM   980  C C   . ARG A 1 129 ? -5.22240  5.03752   -35.39083 1.000 7.69706  ? 131 ARG A C   1 
ATOM   981  O O   . ARG A 1 129 ? -6.28632  5.65580   -35.52009 1.000 6.98986  ? 131 ARG A O   1 
ATOM   982  C CB  . ARG A 1 129 ? -4.99837  2.87326   -34.17603 1.000 4.01271  ? 131 ARG A CB  1 
ATOM   983  C CG  . ARG A 1 129 ? -4.86474  2.10639   -32.86521 1.000 6.07640  ? 131 ARG A CG  1 
ATOM   984  C CD  . ARG A 1 129 ? -3.46714  2.22274   -32.25195 1.000 5.55781  ? 131 ARG A CD  1 
ATOM   985  N NE  . ARG A 1 129 ? -2.40240  1.96314   -33.21730 1.000 3.45120  ? 131 ARG A NE  1 
ATOM   986  C CZ  . ARG A 1 129 ? -1.09665  1.97635   -32.91562 1.000 7.54492  ? 131 ARG A CZ  1 
ATOM   987  N NH1 . ARG A 1 129 ? -0.68584  2.21941   -31.67615 1.000 2.22011  ? 131 ARG A NH1 1 
ATOM   988  N NH2 . ARG A 1 129 ? -0.19190  1.74494   -33.85977 1.000 5.39143  ? 131 ARG A NH2 1 
ATOM   989  N N   . HIS A 1 130 ? -4.35094  4.87979   -36.39063 1.000 5.48954  ? 132 HIS A N   1 
ATOM   990  C CA  . HIS A 1 130 ? -4.62266  5.46439   -37.69376 1.000 5.01080  ? 132 HIS A CA  1 
ATOM   991  C C   . HIS A 1 130 ? -5.78402  4.79326   -38.40220 1.000 5.13975  ? 132 HIS A C   1 
ATOM   992  O O   . HIS A 1 130 ? -6.32442  5.37975   -39.34240 1.000 7.88971  ? 132 HIS A O   1 
ATOM   993  C CB  . HIS A 1 130 ? -3.36777  5.42043   -38.57781 1.000 5.37346  ? 132 HIS A CB  1 
ATOM   994  C CG  . HIS A 1 130 ? -2.39332  6.50503   -38.26021 1.000 5.51857  ? 132 HIS A CG  1 
ATOM   995  N ND1 . HIS A 1 130 ? -2.61171  7.82277   -38.60541 1.000 9.81714  ? 132 HIS A ND1 1 
ATOM   996  C CD2 . HIS A 1 130 ? -1.21478  6.48046   -37.59446 1.000 7.36959  ? 132 HIS A CD2 1 
ATOM   997  C CE1 . HIS A 1 130 ? -1.60162  8.56118   -38.17598 1.000 9.96841  ? 132 HIS A CE1 1 
ATOM   998  N NE2 . HIS A 1 130 ? -0.73734  7.76930   -37.56538 1.000 9.05297  ? 132 HIS A NE2 1 
ATOM   999  N N   . ASN A 1 131 ? -6.18814  3.59493   -37.98965 1.000 4.17100  ? 133 ASN A N   1 
ATOM   1000 C CA  . ASN A 1 131 ? -7.41829  3.01991   -38.52666 1.000 9.26138  ? 133 ASN A CA  1 
ATOM   1001 C C   . ASN A 1 131 ? -8.64764  3.37948   -37.67748 1.000 8.30110  ? 133 ASN A C   1 
ATOM   1002 O O   . ASN A 1 131 ? -9.71013  2.76714   -37.85306 1.000 9.50429  ? 133 ASN A O   1 
ATOM   1003 C CB  . ASN A 1 131 ? -7.27350  1.50082   -38.70373 1.000 7.69719  ? 133 ASN A CB  1 
ATOM   1004 C CG  . ASN A 1 131 ? -7.07960  0.74269   -37.39096 1.000 8.65379  ? 133 ASN A CG  1 
ATOM   1005 O OD1 . ASN A 1 131 ? -7.09044  1.30779   -36.29023 1.000 10.82083 ? 133 ASN A OD1 1 
ATOM   1006 N ND2 . ASN A 1 131 ? -6.90944  -0.56600  -37.51402 1.000 10.24883 ? 133 ASN A ND2 1 
ATOM   1007 N N   . PHE A 1 132 ? -8.50299  4.37623   -36.78489 1.000 6.54327  ? 134 PHE A N   1 
ATOM   1008 C CA  . PHE A 1 132 ? -9.56284  4.98003   -35.96554 1.000 7.57336  ? 134 PHE A CA  1 
ATOM   1009 C C   . PHE A 1 132 ? -10.18211 3.99533   -34.99383 1.000 8.03964  ? 134 PHE A C   1 
ATOM   1010 O O   . PHE A 1 132 ? -11.32915 4.16287   -34.58757 1.000 11.40732 ? 134 PHE A O   1 
ATOM   1011 C CB  . PHE A 1 132 ? -10.65461 5.63567   -36.82252 1.000 6.75416  ? 134 PHE A CB  1 
ATOM   1012 C CG  . PHE A 1 132 ? -10.12092 6.68570   -37.73723 1.000 8.17069  ? 134 PHE A CG  1 
ATOM   1013 C CD1 . PHE A 1 132 ? -9.73407  7.92133   -37.23810 1.000 11.70498 ? 134 PHE A CD1 1 
ATOM   1014 C CD2 . PHE A 1 132 ? -9.93891  6.42013   -39.07951 1.000 5.09397  ? 134 PHE A CD2 1 
ATOM   1015 C CE1 . PHE A 1 132 ? -9.20478  8.89023   -38.07952 1.000 8.86490  ? 134 PHE A CE1 1 
ATOM   1016 C CE2 . PHE A 1 132 ? -9.42373  7.37972   -39.91949 1.000 7.82169  ? 134 PHE A CE2 1 
ATOM   1017 C CZ  . PHE A 1 132 ? -9.05741  8.61672   -39.41807 1.000 6.49305  ? 134 PHE A CZ  1 
ATOM   1018 N N   . THR A 1 133 ? -9.42510  2.97945   -34.61303 1.000 9.60391  ? 135 THR A N   1 
ATOM   1019 C CA  . THR A 1 133 ? -9.78394  2.07990   -33.53347 1.000 7.14480  ? 135 THR A CA  1 
ATOM   1020 C C   . THR A 1 133 ? -8.95525  2.37627   -32.29798 1.000 7.20233  ? 135 THR A C   1 
ATOM   1021 O O   . THR A 1 133 ? -7.96348  3.10893   -32.32979 1.000 10.56013 ? 135 THR A O   1 
ATOM   1022 C CB  . THR A 1 133 ? -9.57343  0.62264   -33.94371 1.000 11.19142 ? 135 THR A CB  1 
ATOM   1023 O OG1 . THR A 1 133 ? -8.16920  0.39471   -34.15262 1.000 8.33638  ? 135 THR A OG1 1 
ATOM   1024 C CG2 . THR A 1 133 ? -10.35843 0.31071   -35.22512 1.000 5.51468  ? 135 THR A CG2 1 
ATOM   1025 N N   . ILE A 1 134 ? -9.36301  1.73793   -31.21189 1.000 8.43087  ? 136 ILE A N   1 
ATOM   1026 C CA  . ILE A 1 134 ? -8.76156  1.84743   -29.89036 1.000 9.79380  ? 136 ILE A CA  1 
ATOM   1027 C C   . ILE A 1 134 ? -8.35199  0.44461   -29.47401 1.000 8.01065  ? 136 ILE A C   1 
ATOM   1028 O O   . ILE A 1 134 ? -9.14126  -0.49517  -29.61627 1.000 9.08507  ? 136 ILE A O   1 
ATOM   1029 C CB  . ILE A 1 134 ? -9.77680  2.45381   -28.89439 1.000 15.47369 ? 136 ILE A CB  1 
ATOM   1030 C CG1 . ILE A 1 134 ? -9.88775  3.96236   -29.11071 1.000 12.64043 ? 136 ILE A CG1 1 
ATOM   1031 C CG2 . ILE A 1 134 ? -9.52217  2.06005   -27.46351 1.000 7.94349  ? 136 ILE A CG2 1 
ATOM   1032 C CD1 . ILE A 1 134 ? -8.59185  4.59151   -29.40420 1.000 9.77083  ? 136 ILE A CD1 1 
ATOM   1033 N N   . LYS A 1 135 ? -7.11663  0.29061   -28.98803 1.000 7.39539  ? 137 LYS A N   1 
ATOM   1034 C CA  . LYS A 1 135 ? -6.64062  -1.01133  -28.51713 1.000 8.38082  ? 137 LYS A CA  1 
ATOM   1035 C C   . LYS A 1 135 ? -6.88298  -1.07570  -27.01263 1.000 7.81064  ? 137 LYS A C   1 
ATOM   1036 O O   . LYS A 1 135 ? -5.98417  -0.91479  -26.18909 1.000 14.78931 ? 137 LYS A O   1 
ATOM   1037 C CB  . LYS A 1 135 ? -5.16997  -1.21104  -28.87580 1.000 16.67271 ? 137 LYS A CB  1 
ATOM   1038 N N   . GLY A 1 136 ? -8.14364  -1.28250  -26.64763 1.000 14.03349 ? 138 GLY A N   1 
ATOM   1039 C CA  . GLY A 1 136 ? -8.56860  -1.16775  -25.27346 1.000 9.05652  ? 138 GLY A CA  1 
ATOM   1040 C C   . GLY A 1 136 ? -8.65493  -2.50547  -24.55114 1.000 11.84868 ? 138 GLY A C   1 
ATOM   1041 O O   . GLY A 1 136 ? -8.35347  -3.57201  -25.08624 1.000 12.63649 ? 138 GLY A O   1 
ATOM   1042 N N   . SER A 1 137 ? -9.08887  -2.41933  -23.29463 1.000 4.12381  ? 139 SER A N   1 
ATOM   1043 C CA  . SER A 1 137 ? -9.35381  -3.57983  -22.45070 1.000 8.03385  ? 139 SER A CA  1 
ATOM   1044 C C   . SER A 1 137 ? -10.79332 -3.41943  -21.97605 1.000 6.64712  ? 139 SER A C   1 
ATOM   1045 O O   . SER A 1 137 ? -11.06521 -2.81189  -20.94231 1.000 9.42317  ? 139 SER A O   1 
ATOM   1046 C CB  . SER A 1 137 ? -8.35619  -3.66494  -21.29244 1.000 11.06298 ? 139 SER A CB  1 
ATOM   1047 O OG  . SER A 1 137 ? -8.74611  -4.65161  -20.35844 1.000 12.42542 ? 139 SER A OG  1 
ATOM   1048 N N   . PHE A 1 138 ? -11.72304 -3.94647  -22.75674 1.000 7.91131  ? 140 PHE A N   1 
ATOM   1049 C CA  . PHE A 1 138 ? -13.13946 -3.72785  -22.53474 1.000 8.99610  ? 140 PHE A CA  1 
ATOM   1050 C C   . PHE A 1 138 ? -13.84465 -5.07029  -22.54341 1.000 9.11436  ? 140 PHE A C   1 
ATOM   1051 O O   . PHE A 1 138 ? -13.65710 -5.86507  -23.47168 1.000 10.09716 ? 140 PHE A O   1 
ATOM   1052 C CB  . PHE A 1 138 ? -13.73085 -2.82551  -23.62164 1.000 9.30198  ? 140 PHE A CB  1 
ATOM   1053 C CG  . PHE A 1 138 ? -13.36891 -1.37207  -23.48462 1.000 6.99960  ? 140 PHE A CG  1 
ATOM   1054 C CD1 . PHE A 1 138 ? -13.41948 -0.74063  -22.25184 1.000 6.60592  ? 140 PHE A CD1 1 
ATOM   1055 C CD2 . PHE A 1 138 ? -13.00833 -0.63195  -24.60341 1.000 6.32088  ? 140 PHE A CD2 1 
ATOM   1056 C CE1 . PHE A 1 138 ? -13.10927 0.60623   -22.13600 1.000 5.71758  ? 140 PHE A CE1 1 
ATOM   1057 C CE2 . PHE A 1 138 ? -12.71485 0.70506   -24.49970 1.000 4.89813  ? 140 PHE A CE2 1 
ATOM   1058 C CZ  . PHE A 1 138 ? -12.75444 1.32392   -23.26230 1.000 3.15021  ? 140 PHE A CZ  1 
ATOM   1059 N N   . LEU A 1 139 ? -14.66846 -5.30864  -21.52972 1.000 9.93388  ? 141 LEU A N   1 
ATOM   1060 C CA  . LEU A 1 139 ? -15.54592 -6.46799  -21.49388 1.000 11.26737 ? 141 LEU A CA  1 
ATOM   1061 C C   . LEU A 1 139 ? -16.97573 -6.04845  -21.84529 1.000 11.02613 ? 141 LEU A C   1 
ATOM   1062 O O   . LEU A 1 139 ? -17.29055 -4.85977  -21.97871 1.000 11.14391 ? 141 LEU A O   1 
ATOM   1063 C CB  . LEU A 1 139 ? -15.49047 -7.13304  -20.11491 1.000 10.17451 ? 141 LEU A CB  1 
ATOM   1064 C CG  . LEU A 1 139 ? -14.07595 -7.44405  -19.58901 1.000 13.86726 ? 141 LEU A CG  1 
ATOM   1065 C CD1 . LEU A 1 139 ? -14.08152 -7.89534  -18.12359 1.000 12.09341 ? 141 LEU A CD1 1 
ATOM   1066 C CD2 . LEU A 1 139 ? -13.43381 -8.50255  -20.45804 1.000 18.03264 ? 141 LEU A CD2 1 
ATOM   1067 N N   . ASN A 1 140 ? -17.83704 -7.05192  -22.01951 1.000 10.02389 ? 142 ASN A N   1 
ATOM   1068 C CA  . ASN A 1 140 ? -19.26225 -6.80934  -22.19771 1.000 11.94336 ? 142 ASN A CA  1 
ATOM   1069 C C   . ASN A 1 140 ? -19.76158 -5.83317  -21.14528 1.000 11.67358 ? 142 ASN A C   1 
ATOM   1070 O O   . ASN A 1 140 ? -19.41587 -5.94361  -19.96615 1.000 6.86609  ? 142 ASN A O   1 
ATOM   1071 C CB  . ASN A 1 140 ? -20.04113 -8.11864  -22.09215 1.000 17.31610 ? 142 ASN A CB  1 
ATOM   1072 C CG  . ASN A 1 140 ? -19.93126 -8.96265  -23.34123 1.000 22.81749 ? 142 ASN A CG  1 
ATOM   1073 O OD1 . ASN A 1 140 ? -19.36516 -8.53690  -24.34128 1.000 27.66153 ? 142 ASN A OD1 1 
ATOM   1074 N ND2 . ASN A 1 140 ? -20.47990 -10.16872 -23.29084 1.000 36.66004 ? 142 ASN A ND2 1 
ATOM   1075 N N   . GLY A 1 141 ? -20.56685 -4.86425  -21.58387 1.000 11.77886 ? 143 GLY A N   1 
ATOM   1076 C CA  . GLY A 1 141 ? -21.14698 -3.87916  -20.69090 1.000 9.87151  ? 143 GLY A CA  1 
ATOM   1077 C C   . GLY A 1 141 ? -20.29187 -2.65424  -20.41755 1.000 7.56676  ? 143 GLY A C   1 
ATOM   1078 O O   . GLY A 1 141 ? -20.73055 -1.76990  -19.66732 1.000 5.66051  ? 143 GLY A O   1 
ATOM   1079 N N   . SER A 1 142 ? -19.10481 -2.55618  -21.01760 1.000 4.90278  ? 144 SER A N   1 
ATOM   1080 C CA  . SER A 1 142 ? -18.24240 -1.40469  -20.80191 1.000 2.72388  ? 144 SER A CA  1 
ATOM   1081 C C   . SER A 1 142 ? -18.67689 -0.19087  -21.59959 1.000 3.48728  ? 144 SER A C   1 
ATOM   1082 O O   . SER A 1 142 ? -18.09152 0.88231   -21.41925 1.000 1.57023  ? 144 SER A O   1 
ATOM   1083 C CB  . SER A 1 142 ? -16.79152 -1.75894  -21.14711 1.000 5.98366  ? 144 SER A CB  1 
ATOM   1084 O OG  . SER A 1 142 ? -16.71678 -2.33075  -22.43851 1.000 9.38139  ? 144 SER A OG  1 
ATOM   1085 N N   . CYS A 1 143 ? -19.69989 -0.33028  -22.45629 1.000 4.64139  ? 145 CYS A N   1 
ATOM   1086 C CA  . CYS A 1 143 ? -20.12560 0.76661   -23.31406 1.000 2.09767  ? 145 CYS A CA  1 
ATOM   1087 C C   . CYS A 1 143 ? -20.48477 1.99000   -22.48268 1.000 1.62730  ? 145 CYS A C   1 
ATOM   1088 O O   . CYS A 1 143 ? -21.04300 1.87276   -21.39426 1.000 1.80960  ? 145 CYS A O   1 
ATOM   1089 C CB  . CYS A 1 143 ? -21.32865 0.33425   -24.16100 1.000 3.93223  ? 145 CYS A CB  1 
ATOM   1090 S SG  . CYS A 1 143 ? -21.18183 -1.26865  -24.93630 1.000 8.36356  ? 145 CYS A SG  1 
ATOM   1091 N N   . GLY A 1 144 ? -20.13947 3.17542   -22.99089 1.000 1.78349  ? 146 GLY A N   1 
ATOM   1092 C CA  . GLY A 1 144 ? -20.32794 4.39644   -22.23605 1.000 3.18954  ? 146 GLY A CA  1 
ATOM   1093 C C   . GLY A 1 144 ? -19.16959 4.80523   -21.33534 1.000 3.00014  ? 146 GLY A C   1 
ATOM   1094 O O   . GLY A 1 144 ? -19.20352 5.91154   -20.78138 1.000 2.40180  ? 146 GLY A O   1 
ATOM   1095 N N   . SER A 1 145 ? -18.17692 3.93770   -21.13381 1.000 4.35333  ? 147 SER A N   1 
ATOM   1096 C CA  . SER A 1 145 ? -16.89788 4.35149   -20.55741 1.000 3.80010  ? 147 SER A CA  1 
ATOM   1097 C C   . SER A 1 145 ? -16.23997 5.39923   -21.44443 1.000 3.23651  ? 147 SER A C   1 
ATOM   1098 O O   . SER A 1 145 ? -16.37455 5.37677   -22.66805 1.000 4.07935  ? 147 SER A O   1 
ATOM   1099 C CB  . SER A 1 145 ? -15.95122 3.15409   -20.41558 1.000 4.90116  ? 147 SER A CB  1 
ATOM   1100 O OG  . SER A 1 145 ? -16.45900 2.17097   -19.52445 1.000 5.30843  ? 147 SER A OG  1 
ATOM   1101 N N   . VAL A 1 146 ? -15.50400 6.31849   -20.83087 1.000 2.69162  ? 148 VAL A N   1 
ATOM   1102 C CA  . VAL A 1 146 ? -15.02364 7.46583   -21.58092 1.000 2.10843  ? 148 VAL A CA  1 
ATOM   1103 C C   . VAL A 1 146 ? -13.50802 7.57983   -21.48247 1.000 3.20247  ? 148 VAL A C   1 
ATOM   1104 O O   . VAL A 1 146 ? -12.87345 7.09919   -20.53416 1.000 2.86310  ? 148 VAL A O   1 
ATOM   1105 C CB  . VAL A 1 146 ? -15.70568 8.78104   -21.13772 1.000 2.16425  ? 148 VAL A CB  1 
ATOM   1106 C CG1 . VAL A 1 146 ? -17.21749 8.72987   -21.44244 1.000 4.02683  ? 148 VAL A CG1 1 
ATOM   1107 C CG2 . VAL A 1 146 ? -15.44490 9.06712   -19.66914 1.000 2.37695  ? 148 VAL A CG2 1 
ATOM   1108 N N   . GLY A 1 147 ? -12.92979 8.19331   -22.51433 1.000 2.54257  ? 149 GLY A N   1 
ATOM   1109 C CA  . GLY A 1 147 ? -11.51427 8.50590   -22.56117 1.000 2.59706  ? 149 GLY A CA  1 
ATOM   1110 C C   . GLY A 1 147 ? -11.33945 10.00634  -22.42765 1.000 4.67619  ? 149 GLY A C   1 
ATOM   1111 O O   . GLY A 1 147 ? -12.19072 10.77929  -22.88346 1.000 3.06875  ? 149 GLY A O   1 
ATOM   1112 N N   . PHE A 1 148 ? -10.23207 10.42387  -21.80128 1.000 3.68678  ? 150 PHE A N   1 
ATOM   1113 C CA  . PHE A 1 148 ? -10.07927 11.82461  -21.41139 1.000 5.77775  ? 150 PHE A CA  1 
ATOM   1114 C C   . PHE A 1 148 ? -8.60941  12.18457  -21.22896 1.000 6.48685  ? 150 PHE A C   1 
ATOM   1115 O O   . PHE A 1 148 ? -7.75676  11.32173  -21.02932 1.000 4.29648  ? 150 PHE A O   1 
ATOM   1116 C CB  . PHE A 1 148 ? -10.83850 12.12939  -20.11271 1.000 4.18128  ? 150 PHE A CB  1 
ATOM   1117 C CG  . PHE A 1 148 ? -10.38285 11.30704  -18.94374 1.000 6.06204  ? 150 PHE A CG  1 
ATOM   1118 C CD1 . PHE A 1 148 ? -10.82145 9.99648   -18.79397 1.000 4.69821  ? 150 PHE A CD1 1 
ATOM   1119 C CD2 . PHE A 1 148 ? -9.51623  11.83170  -17.99733 1.000 5.70473  ? 150 PHE A CD2 1 
ATOM   1120 C CE1 . PHE A 1 148 ? -10.40901 9.22560   -17.73237 1.000 2.01290  ? 150 PHE A CE1 1 
ATOM   1121 C CE2 . PHE A 1 148 ? -9.10622  11.06070  -16.92441 1.000 4.89801  ? 150 PHE A CE2 1 
ATOM   1122 C CZ  . PHE A 1 148 ? -9.55962  9.76149   -16.79247 1.000 4.12287  ? 150 PHE A CZ  1 
ATOM   1123 N N   . ASN A 1 149 ? -8.33360  13.48309  -21.30433 1.000 8.36514  ? 151 ASN A N   1 
ATOM   1124 C CA  . ASN A 1 149 ? -7.10452  14.07207  -20.80134 1.000 9.74364  ? 151 ASN A CA  1 
ATOM   1125 C C   . ASN A 1 149 ? -7.46139  15.11003  -19.75286 1.000 11.84476 ? 151 ASN A C   1 
ATOM   1126 O O   . ASN A 1 149 ? -8.57957  15.63836  -19.73835 1.000 10.82857 ? 151 ASN A O   1 
ATOM   1127 C CB  . ASN A 1 149 ? -6.29082  14.72882  -21.91245 1.000 8.41538  ? 151 ASN A CB  1 
ATOM   1128 C CG  . ASN A 1 149 ? -5.69305  13.71710  -22.83081 1.000 13.85458 ? 151 ASN A CG  1 
ATOM   1129 O OD1 . ASN A 1 149 ? -4.77041  12.99797  -22.44799 1.000 11.80882 ? 151 ASN A OD1 1 
ATOM   1130 N ND2 . ASN A 1 149 ? -6.24185  13.60467  -24.02953 1.000 9.44116  ? 151 ASN A ND2 1 
ATOM   1131 N N   . ILE A 1 150 ? -6.50308  15.40959  -18.87765 1.000 7.77793  ? 152 ILE A N   1 
ATOM   1132 C CA  . ILE A 1 150 ? -6.67675  16.45826  -17.88011 1.000 14.30124 ? 152 ILE A CA  1 
ATOM   1133 C C   . ILE A 1 150 ? -5.50651  17.42193  -17.99055 1.000 22.02179 ? 152 ILE A C   1 
ATOM   1134 O O   . ILE A 1 150 ? -4.34771  17.01027  -17.89770 1.000 22.90547 ? 152 ILE A O   1 
ATOM   1135 C CB  . ILE A 1 150 ? -6.80108  15.89387  -16.45817 1.000 14.76435 ? 152 ILE A CB  1 
ATOM   1136 C CG1 . ILE A 1 150 ? -7.85973  14.79005  -16.43402 1.000 9.97324  ? 152 ILE A CG1 1 
ATOM   1137 C CG2 . ILE A 1 150 ? -7.16682  17.00793  -15.48006 1.000 16.44228 ? 152 ILE A CG2 1 
ATOM   1138 C CD1 . ILE A 1 150 ? -8.18375  14.26998  -15.05643 1.000 9.17054  ? 152 ILE A CD1 1 
ATOM   1139 N N   . ASP A 1 151 ? -5.80808  18.69951  -18.20088 1.000 28.15103 ? 153 ASP A N   1 
ATOM   1140 C CA  . ASP A 1 151 ? -4.78532  19.71824  -18.41328 1.000 28.37687 ? 153 ASP A CA  1 
ATOM   1141 C C   . ASP A 1 151 ? -5.23133  20.97181  -17.67561 1.000 34.45849 ? 153 ASP A C   1 
ATOM   1142 O O   . ASP A 1 151 ? -6.20139  21.61516  -18.08419 1.000 37.86559 ? 153 ASP A O   1 
ATOM   1143 C CB  . ASP A 1 151 ? -4.57449  19.98534  -19.90671 1.000 31.94465 ? 153 ASP A CB  1 
ATOM   1144 C CG  . ASP A 1 151 ? -3.39717  19.19309  -20.48857 1.000 41.32639 ? 153 ASP A CG  1 
ATOM   1145 O OD1 . ASP A 1 151 ? -2.24412  19.55573  -20.17200 1.000 47.29246 ? 153 ASP A OD1 1 
ATOM   1146 O OD2 . ASP A 1 151 ? -3.60782  18.22410  -21.26320 1.000 33.34595 ? 153 ASP A OD2 1 
ATOM   1147 N N   . TYR A 1 152 ? -4.53878  21.29506  -16.57892 1.000 37.17382 ? 154 TYR A N   1 
ATOM   1148 C CA  . TYR A 1 152 ? -4.87570  22.42816  -15.71369 1.000 27.53809 ? 154 TYR A CA  1 
ATOM   1149 C C   . TYR A 1 152 ? -6.26924  22.27259  -15.10780 1.000 34.42598 ? 154 TYR A C   1 
ATOM   1150 O O   . TYR A 1 152 ? -7.11196  23.16898  -15.19080 1.000 45.03698 ? 154 TYR A O   1 
ATOM   1151 C CB  . TYR A 1 152 ? -4.75166  23.75687  -16.46131 1.000 31.59870 ? 154 TYR A CB  1 
ATOM   1152 N N   . ASP A 1 153 ? -6.50832  21.11884  -14.48618 1.000 30.97822 ? 155 ASP A N   1 
ATOM   1153 C CA  . ASP A 1 153 ? -7.75734  20.78983  -13.79533 1.000 33.60192 ? 155 ASP A CA  1 
ATOM   1154 C C   . ASP A 1 153 ? -9.00000  20.91117  -14.67565 1.000 24.70846 ? 155 ASP A C   1 
ATOM   1155 O O   . ASP A 1 153 ? -10.12977 20.89529  -14.15306 1.000 28.23770 ? 155 ASP A O   1 
ATOM   1156 C CB  . ASP A 1 153 ? -7.94077  21.63676  -12.52915 1.000 32.04391 ? 155 ASP A CB  1 
ATOM   1157 C CG  . ASP A 1 153 ? -7.03283  21.18637  -11.39965 1.000 49.83567 ? 155 ASP A CG  1 
ATOM   1158 O OD1 . ASP A 1 153 ? -7.11744  20.00044  -10.99737 1.000 46.05315 ? 155 ASP A OD1 1 
ATOM   1159 O OD2 . ASP A 1 153 ? -6.22081  22.01324  -10.92575 1.000 58.01509 ? 155 ASP A OD2 1 
ATOM   1160 N N   . CYS A 1 154 ? -8.83448  21.02336  -15.99019 1.000 23.73478 ? 156 CYS A N   1 
ATOM   1161 C CA  . CYS A 1 154 ? -9.94186  20.95001  -16.93817 1.000 22.37126 ? 156 CYS A CA  1 
ATOM   1162 C C   . CYS A 1 154 ? -9.87998  19.60012  -17.63932 1.000 14.70300 ? 156 CYS A C   1 
ATOM   1163 O O   . CYS A 1 154 ? -8.82846  19.21796  -18.16042 1.000 14.38569 ? 156 CYS A O   1 
ATOM   1164 C CB  . CYS A 1 154 ? -9.88100  22.09244  -17.95708 1.000 19.09815 ? 156 CYS A CB  1 
ATOM   1165 S SG  . CYS A 1 154 ? -11.11128 22.00482  -19.29105 1.000 21.99565 ? 156 CYS A SG  1 
ATOM   1166 N N   . VAL A 1 155 ? -10.99568 18.88062  -17.63025 1.000 12.18100 ? 157 VAL A N   1 
ATOM   1167 C CA  . VAL A 1 155 ? -11.06156 17.51647  -18.14037 1.000 8.67225  ? 157 VAL A CA  1 
ATOM   1168 C C   . VAL A 1 155 ? -11.50020 17.57127  -19.60008 1.000 11.99660 ? 157 VAL A C   1 
ATOM   1169 O O   . VAL A 1 155 ? -12.56534 18.11291  -19.91338 1.000 11.54305 ? 157 VAL A O   1 
ATOM   1170 C CB  . VAL A 1 155 ? -12.03212 16.66923  -17.30428 1.000 13.42599 ? 157 VAL A CB  1 
ATOM   1171 C CG1 . VAL A 1 155 ? -12.32143 15.33554  -17.98444 1.000 10.63282 ? 157 VAL A CG1 1 
ATOM   1172 C CG2 . VAL A 1 155 ? -11.48551 16.46752  -15.89440 1.000 10.23333 ? 157 VAL A CG2 1 
ATOM   1173 N N   . SER A 1 156 ? -10.68990 17.01087  -20.49412 1.000 5.97827  ? 158 SER A N   1 
ATOM   1174 C CA  . SER A 1 156 ? -10.99258 16.98937  -21.92611 1.000 8.21113  ? 158 SER A CA  1 
ATOM   1175 C C   . SER A 1 156 ? -11.53985 15.62167  -22.29658 1.000 11.13956 ? 158 SER A C   1 
ATOM   1176 O O   . SER A 1 156 ? -10.77010 14.66988  -22.44868 1.000 7.58088  ? 158 SER A O   1 
ATOM   1177 C CB  . SER A 1 156 ? -9.75506  17.30317  -22.76004 1.000 11.85613 ? 158 SER A CB  1 
ATOM   1178 O OG  . SER A 1 156 ? -9.67671  18.68152  -23.03307 1.000 27.47129 ? 158 SER A OG  1 
ATOM   1179 N N   . PHE A 1 157 ? -12.86804 15.52850  -22.48000 1.000 6.57408  ? 159 PHE A N   1 
ATOM   1180 C CA  . PHE A 1 157 ? -13.48700 14.28319  -22.91985 1.000 4.82874  ? 159 PHE A CA  1 
ATOM   1181 C C   . PHE A 1 157 ? -13.33693 14.13645  -24.43515 1.000 8.96026  ? 159 PHE A C   1 
ATOM   1182 O O   . PHE A 1 157 ? -13.78141 14.99986  -25.19842 1.000 8.48322  ? 159 PHE A O   1 
ATOM   1183 C CB  . PHE A 1 157 ? -14.95820 14.23645  -22.50752 1.000 6.31406  ? 159 PHE A CB  1 
ATOM   1184 C CG  . PHE A 1 157 ? -15.16734 14.14492  -21.01411 1.000 4.88232  ? 159 PHE A CG  1 
ATOM   1185 C CD1 . PHE A 1 157 ? -14.93208 12.96155  -20.33460 1.000 7.25152  ? 159 PHE A CD1 1 
ATOM   1186 C CD2 . PHE A 1 157 ? -15.58266 15.24171  -20.29370 1.000 5.25955  ? 159 PHE A CD2 1 
ATOM   1187 C CE1 . PHE A 1 157 ? -15.13348 12.86969  -18.95714 1.000 5.06259  ? 159 PHE A CE1 1 
ATOM   1188 C CE2 . PHE A 1 157 ? -15.77951 15.16215  -18.90941 1.000 7.25101  ? 159 PHE A CE2 1 
ATOM   1189 C CZ  . PHE A 1 157 ? -15.56662 13.97227  -18.25020 1.000 5.92178  ? 159 PHE A CZ  1 
ATOM   1190 N N   . CYS A 1 158 ? -12.72798 13.03352  -24.87406 1.000 4.85253  ? 160 CYS A N   1 
ATOM   1191 C CA  . CYS A 1 158 ? -12.42916 12.83175  -26.27859 1.000 2.98366  ? 160 CYS A CA  1 
ATOM   1192 C C   . CYS A 1 158 ? -12.97137 11.52850  -26.85453 1.000 5.75338  ? 160 CYS A C   1 
ATOM   1193 O O   . CYS A 1 158 ? -12.96057 11.35998  -28.08310 1.000 4.72844  ? 160 CYS A O   1 
ATOM   1194 C CB  . CYS A 1 158 ? -10.90881 12.88992  -26.50786 1.000 6.27189  ? 160 CYS A CB  1 
ATOM   1195 S SG  . CYS A 1 158 ? -9.94945  11.64130  -25.61356 1.000 7.67016  ? 160 CYS A SG  1 
ATOM   1196 N N   . TYR A 1 159 ? -13.44529 10.60993  -26.02088 1.000 5.98170  ? 161 TYR A N   1 
ATOM   1197 C CA  . TYR A 1 159 ? -13.86485 9.29691   -26.49014 1.000 4.40587  ? 161 TYR A CA  1 
ATOM   1198 C C   . TYR A 1 159 ? -14.95825 8.78590   -25.57245 1.000 3.23385  ? 161 TYR A C   1 
ATOM   1199 O O   . TYR A 1 159 ? -14.81311 8.86099   -24.35019 1.000 1.64026  ? 161 TYR A O   1 
ATOM   1200 C CB  . TYR A 1 159 ? -12.69054 8.31239   -26.49939 1.000 1.79617  ? 161 TYR A CB  1 
ATOM   1201 C CG  . TYR A 1 159 ? -13.04424 6.89219   -26.90138 1.000 2.66494  ? 161 TYR A CG  1 
ATOM   1202 C CD1 . TYR A 1 159 ? -13.03108 6.50839   -28.24118 1.000 3.90435  ? 161 TYR A CD1 1 
ATOM   1203 C CD2 . TYR A 1 159 ? -13.36654 5.92498   -25.94226 1.000 2.26594  ? 161 TYR A CD2 1 
ATOM   1204 C CE1 . TYR A 1 159 ? -13.33977 5.20318   -28.62353 1.000 3.80632  ? 161 TYR A CE1 1 
ATOM   1205 C CE2 . TYR A 1 159 ? -13.65603 4.59870   -26.31563 1.000 1.59155  ? 161 TYR A CE2 1 
ATOM   1206 C CZ  . TYR A 1 159 ? -13.65516 4.26062   -27.66395 1.000 1.58982  ? 161 TYR A CZ  1 
ATOM   1207 O OH  . TYR A 1 159 ? -13.94608 2.98023   -28.06496 1.000 3.38881  ? 161 TYR A OH  1 
ATOM   1208 N N   . MET A 1 160 ? -16.04215 8.27535   -26.16200 1.000 2.98487  ? 162 MET A N   1 
ATOM   1209 C CA  . MET A 1 160 ? -16.98250 7.40909   -25.46141 1.000 2.60627  ? 162 MET A CA  1 
ATOM   1210 C C   . MET A 1 160 ? -17.00900 6.06034   -26.16845 1.000 2.16554  ? 162 MET A C   1 
ATOM   1211 O O   . MET A 1 160 ? -17.03952 6.00249   -27.40248 1.000 2.60201  ? 162 MET A O   1 
ATOM   1212 C CB  . MET A 1 160 ? -18.38442 8.02581   -25.40514 1.000 0.96818  ? 162 MET A CB  1 
ATOM   1213 C CG  . MET A 1 160 ? -19.43561 7.08648   -24.83246 1.000 5.53357  ? 162 MET A CG  1 
ATOM   1214 S SD  . MET A 1 160 ? -21.06467 7.83719   -24.68866 1.000 10.62555 ? 162 MET A SD  1 
ATOM   1215 C CE  . MET A 1 160 ? -20.89489 8.70705   -23.12106 1.000 5.19890  ? 162 MET A CE  1 
ATOM   1216 N N   . HIS A 1 161 ? -17.00443 4.97805   -25.39047 1.000 1.83428  ? 163 HIS A N   1 
ATOM   1217 C CA  . HIS A 1 161 ? -16.88361 3.63206   -25.94379 1.000 3.07042  ? 163 HIS A CA  1 
ATOM   1218 C C   . HIS A 1 161 ? -18.24308 3.08765   -26.37857 1.000 3.96053  ? 163 HIS A C   1 
ATOM   1219 O O   . HIS A 1 161 ? -19.21965 3.17180   -25.62323 1.000 3.52296  ? 163 HIS A O   1 
ATOM   1220 C CB  . HIS A 1 161 ? -16.26460 2.67952   -24.92177 1.000 4.27677  ? 163 HIS A CB  1 
ATOM   1221 C CG  . HIS A 1 161 ? -16.15938 1.27303   -25.41849 1.000 4.23040  ? 163 HIS A CG  1 
ATOM   1222 N ND1 . HIS A 1 161 ? -15.64409 0.96980   -26.65990 1.000 2.15512  ? 163 HIS A ND1 1 
ATOM   1223 C CD2 . HIS A 1 161 ? -16.52164 0.09425   -24.86146 1.000 4.70866  ? 163 HIS A CD2 1 
ATOM   1224 C CE1 . HIS A 1 161 ? -15.69376 -0.33642  -26.84499 1.000 3.94259  ? 163 HIS A CE1 1 
ATOM   1225 N NE2 . HIS A 1 161 ? -16.20637 -0.89250  -25.76312 1.000 2.95085  ? 163 HIS A NE2 1 
ATOM   1226 N N   . HIS A 1 162 ? -18.29218 2.49811   -27.58492 1.000 2.55336  ? 164 HIS A N   1 
ATOM   1227 C CA  . HIS A 1 162 ? -19.50925 1.90514   -28.13665 1.000 4.36730  ? 164 HIS A CA  1 
ATOM   1228 C C   . HIS A 1 162 ? -19.41128 0.40169   -28.36682 1.000 4.31252  ? 164 HIS A C   1 
ATOM   1229 O O   . HIS A 1 162 ? -20.32213 -0.32892  -27.95949 1.000 5.05900  ? 164 HIS A O   1 
ATOM   1230 C CB  . HIS A 1 162 ? -19.90647 2.60823   -29.46458 1.000 1.55957  ? 164 HIS A CB  1 
ATOM   1231 C CG  . HIS A 1 162 ? -20.47568 3.98234   -29.26994 1.000 3.08943  ? 164 HIS A CG  1 
ATOM   1232 N ND1 . HIS A 1 162 ? -21.77162 4.31758   -29.61463 1.000 2.75087  ? 164 HIS A ND1 1 
ATOM   1233 C CD2 . HIS A 1 162 ? -19.92710 5.10107   -28.74373 1.000 1.28378  ? 164 HIS A CD2 1 
ATOM   1234 C CE1 . HIS A 1 162 ? -21.98259 5.59159   -29.33502 1.000 2.22156  ? 164 HIS A CE1 1 
ATOM   1235 N NE2 . HIS A 1 162 ? -20.87949 6.08631   -28.79913 1.000 2.98944  ? 164 HIS A NE2 1 
ATOM   1236 N N   . MET A 1 163 ? -18.36897 -0.09570  -29.04165 1.000 3.24878  ? 165 MET A N   1 
ATOM   1237 C CA  . MET A 1 163 ? -18.43183 -1.48575  -29.49047 1.000 6.63528  ? 165 MET A CA  1 
ATOM   1238 C C   . MET A 1 163 ? -17.06257 -2.12021  -29.68850 1.000 4.13828  ? 165 MET A C   1 
ATOM   1239 O O   . MET A 1 163 ? -16.04494 -1.44223  -29.83648 1.000 6.34805  ? 165 MET A O   1 
ATOM   1240 C CB  . MET A 1 163 ? -19.18900 -1.60515  -30.80366 1.000 7.45816  ? 165 MET A CB  1 
ATOM   1241 C CG  . MET A 1 163 ? -18.59336 -0.78248  -31.91563 1.000 4.55965  ? 165 MET A CG  1 
ATOM   1242 S SD  . MET A 1 163 ? -19.93272 -0.38499  -33.06333 1.000 23.19280 ? 165 MET A SD  1 
ATOM   1243 C CE  . MET A 1 163 ? -20.72666 -1.99831  -33.19291 1.000 13.97366 ? 165 MET A CE  1 
ATOM   1244 N N   . GLU A 1 164 ? -17.08062 -3.44766  -29.73159 1.000 5.71059  ? 166 GLU A N   1 
ATOM   1245 C CA  . GLU A 1 164 ? -15.92584 -4.27826  -30.04401 1.000 10.05292 ? 166 GLU A CA  1 
ATOM   1246 C C   . GLU A 1 164 ? -16.01532 -4.72073  -31.50363 1.000 10.05064 ? 166 GLU A C   1 
ATOM   1247 O O   . GLU A 1 164 ? -17.10092 -5.04290  -31.99392 1.000 7.36212  ? 166 GLU A O   1 
ATOM   1248 C CB  . GLU A 1 164 ? -15.87105 -5.50262  -29.11517 1.000 8.10556  ? 166 GLU A CB  1 
ATOM   1249 C CG  . GLU A 1 164 ? -14.51881 -6.24332  -29.11521 1.000 16.02921 ? 166 GLU A CG  1 
ATOM   1250 C CD  . GLU A 1 164 ? -14.40823 -7.29776  -28.00924 1.000 24.43979 ? 166 GLU A CD  1 
ATOM   1251 O OE1 . GLU A 1 164 ? -15.06558 -8.34905  -28.14981 1.000 33.01897 ? 166 GLU A OE1 1 
ATOM   1252 O OE2 . GLU A 1 164 ? -13.67521 -7.07987  -27.00207 1.000 20.03000 ? 166 GLU A OE2 1 
ATOM   1253 N N   . LEU A 1 165 ? -14.86849 -4.71092  -32.20459 1.000 7.70091  ? 167 LEU A N   1 
ATOM   1254 C CA  . LEU A 1 165 ? -14.70377 -5.22713  -33.55837 1.000 9.75230  ? 167 LEU A CA  1 
ATOM   1255 C C   . LEU A 1 165 ? -14.19132 -6.66582  -33.52459 1.000 10.70938 ? 167 LEU A C   1 
ATOM   1256 O O   . LEU A 1 165 ? -13.64528 -7.11776  -32.51610 1.000 11.73614 ? 167 LEU A O   1 
ATOM   1257 C CB  . LEU A 1 165 ? -13.72324 -4.34849  -34.36063 1.000 10.70378 ? 167 LEU A CB  1 
ATOM   1258 C CG  . LEU A 1 165 ? -14.09425 -2.96630  -34.92499 1.000 10.41675 ? 167 LEU A CG  1 
ATOM   1259 C CD1 . LEU A 1 165 ? -15.51202 -2.93207  -35.46841 1.000 10.44602 ? 167 LEU A CD1 1 
ATOM   1260 C CD2 . LEU A 1 165 ? -13.84282 -1.82814  -33.95847 1.000 17.19812 ? 167 LEU A CD2 1 
ATOM   1261 N N   . PRO A 1 166 ? -14.34090 -7.41477  -34.62301 1.000 13.68343 ? 168 PRO A N   1 
ATOM   1262 C CA  . PRO A 1 166 ? -13.91914 -8.83177  -34.62380 1.000 11.52160 ? 168 PRO A CA  1 
ATOM   1263 C C   . PRO A 1 166 ? -12.48106 -9.10356  -34.18625 1.000 18.61027 ? 168 PRO A C   1 
ATOM   1264 O O   . PRO A 1 166 ? -12.23615 -10.16456 -33.59813 1.000 17.95500 ? 168 PRO A O   1 
ATOM   1265 C CB  . PRO A 1 166 ? -14.12432 -9.25657  -36.08490 1.000 11.78516 ? 168 PRO A CB  1 
ATOM   1266 C CG  . PRO A 1 166 ? -14.39000 -7.95945  -36.85668 1.000 20.35018 ? 168 PRO A CG  1 
ATOM   1267 C CD  . PRO A 1 166 ? -15.04219 -7.06004  -35.86754 1.000 14.30974 ? 168 PRO A CD  1 
ATOM   1268 N N   . THR A 1 167 ? -11.52539 -8.20572  -34.45802 1.000 10.80351 ? 169 THR A N   1 
ATOM   1269 C CA  . THR A 1 167 ? -10.12829 -8.42711  -34.08368 1.000 13.48135 ? 169 THR A CA  1 
ATOM   1270 C C   . THR A 1 167 ? -9.81624  -8.07651  -32.62663 1.000 20.15372 ? 169 THR A C   1 
ATOM   1271 O O   . THR A 1 167 ? -8.64625  -8.12529  -32.23723 1.000 17.92927 ? 169 THR A O   1 
ATOM   1272 C CB  . THR A 1 167 ? -9.20424  -7.63162  -35.00740 1.000 13.81665 ? 169 THR A CB  1 
ATOM   1273 O OG1 . THR A 1 167 ? -7.88236  -7.62987  -34.47004 1.000 38.00979 ? 169 THR A OG1 1 
ATOM   1274 C CG2 . THR A 1 167 ? -9.65957  -6.20293  -35.10767 1.000 17.89902 ? 169 THR A CG2 1 
ATOM   1275 N N   . GLY A 1 168 ? -10.80463 -7.72357  -31.80524 1.000 12.42122 ? 170 GLY A N   1 
ATOM   1276 C CA  . GLY A 1 168 ? -10.53027 -7.42793  -30.41432 1.000 10.28710 ? 170 GLY A CA  1 
ATOM   1277 C C   . GLY A 1 168 ? -10.31508 -5.96631  -30.09410 1.000 11.96599 ? 170 GLY A C   1 
ATOM   1278 O O   . GLY A 1 168 ? -10.14133 -5.62228  -28.91428 1.000 15.82194 ? 170 GLY A O   1 
ATOM   1279 N N   . VAL A 1 169 ? -10.32295 -5.09328  -31.09720 1.000 7.30852  ? 171 VAL A N   1 
ATOM   1280 C CA  . VAL A 1 169 ? -10.15823 -3.65941  -30.87298 1.000 8.78134  ? 171 VAL A CA  1 
ATOM   1281 C C   . VAL A 1 169 ? -11.52932 -2.99200  -30.78073 1.000 9.73087  ? 171 VAL A C   1 
ATOM   1282 O O   . VAL A 1 169 ? -12.56686 -3.64375  -30.93618 1.000 7.28368  ? 171 VAL A O   1 
ATOM   1283 C CB  . VAL A 1 169 ? -9.29751  -3.03103  -31.98087 1.000 6.74536  ? 171 VAL A CB  1 
ATOM   1284 C CG1 . VAL A 1 169 ? -7.90521  -3.68654  -31.98164 1.000 10.53045 ? 171 VAL A CG1 1 
ATOM   1285 C CG2 . VAL A 1 169 ? -9.96793  -3.19086  -33.33073 1.000 8.54511  ? 171 VAL A CG2 1 
ATOM   1286 N N   . HIS A 1 170 ? -11.54635 -1.69154  -30.53719 1.000 7.27376  ? 172 HIS A N   1 
ATOM   1287 C CA  . HIS A 1 170 ? -12.75456 -1.03568  -30.07896 1.000 7.32382  ? 172 HIS A CA  1 
ATOM   1288 C C   . HIS A 1 170 ? -13.01365 0.23126   -30.88539 1.000 8.38013  ? 172 HIS A C   1 
ATOM   1289 O O   . HIS A 1 170 ? -12.08134 0.90102   -31.35132 1.000 6.62057  ? 172 HIS A O   1 
ATOM   1290 C CB  . HIS A 1 170 ? -12.64195 -0.75501  -28.56976 1.000 7.56405  ? 172 HIS A CB  1 
ATOM   1291 C CG  . HIS A 1 170 ? -12.31129 -1.98097  -27.77103 1.000 8.97470  ? 172 HIS A CG  1 
ATOM   1292 N ND1 . HIS A 1 170 ? -11.03337 -2.26839  -27.33604 1.000 9.47014  ? 172 HIS A ND1 1 
ATOM   1293 C CD2 . HIS A 1 170 ? -13.08404 -3.02391  -27.38112 1.000 7.76131  ? 172 HIS A CD2 1 
ATOM   1294 C CE1 . HIS A 1 170 ? -11.03711 -3.42767  -26.70097 1.000 7.80146  ? 172 HIS A CE1 1 
ATOM   1295 N NE2 . HIS A 1 170 ? -12.27015 -3.90329  -26.70810 1.000 10.19787 ? 172 HIS A NE2 1 
ATOM   1296 N N   . ALA A 1 171 ? -14.30322 0.53517   -31.06242 1.000 6.06529  ? 173 ALA A N   1 
ATOM   1297 C CA  . ALA A 1 171 ? -14.75422 1.70884   -31.79483 1.000 3.92889  ? 173 ALA A CA  1 
ATOM   1298 C C   . ALA A 1 171 ? -15.70459 2.52377   -30.92790 1.000 2.20486  ? 173 ALA A C   1 
ATOM   1299 O O   . ALA A 1 171 ? -16.45991 1.98483   -30.11752 1.000 2.71400  ? 173 ALA A O   1 
ATOM   1300 C CB  . ALA A 1 171 ? -15.43737 1.30865   -33.11225 1.000 4.71169  ? 173 ALA A CB  1 
ATOM   1301 N N   . GLY A 1 172 ? -15.66563 3.83099   -31.11448 1.000 1.77710  ? 174 GLY A N   1 
ATOM   1302 C CA  . GLY A 1 172 ? -16.48138 4.72029   -30.32504 1.000 2.33720  ? 174 GLY A CA  1 
ATOM   1303 C C   . GLY A 1 172 ? -16.54599 6.08327   -30.97476 1.000 4.34838  ? 174 GLY A C   1 
ATOM   1304 O O   . GLY A 1 172 ? -16.10237 6.26795   -32.11147 1.000 5.74523  ? 174 GLY A O   1 
ATOM   1305 N N   . THR A 1 173 ? -17.09929 7.04411   -30.23046 1.000 3.99596  ? 175 THR A N   1 
ATOM   1306 C CA  . THR A 1 173 ? -17.41304 8.37316   -30.73724 1.000 4.35276  ? 175 THR A CA  1 
ATOM   1307 C C   . THR A 1 173 ? -16.75459 9.45502   -29.89683 1.000 3.44226  ? 175 THR A C   1 
ATOM   1308 O O   . THR A 1 173 ? -16.33865 9.21905   -28.75679 1.000 2.05820  ? 175 THR A O   1 
ATOM   1309 C CB  . THR A 1 173 ? -18.93707 8.64037   -30.73085 1.000 4.61149  ? 175 THR A CB  1 
ATOM   1310 O OG1 . THR A 1 173 ? -19.41666 8.69645   -29.37083 1.000 5.08767  ? 175 THR A OG1 1 
ATOM   1311 C CG2 . THR A 1 173 ? -19.68448 7.56758   -31.49340 1.000 3.44168  ? 175 THR A CG2 1 
ATOM   1312 N N   . ASP A 1 174 ? -16.72388 10.67526  -30.44289 1.000 2.79374  ? 176 ASP A N   1 
ATOM   1313 C CA  . ASP A 1 174 ? -16.50980 11.82616  -29.57721 1.000 3.89553  ? 176 ASP A CA  1 
ATOM   1314 C C   . ASP A 1 174 ? -17.78732 12.07804  -28.76011 1.000 4.98129  ? 176 ASP A C   1 
ATOM   1315 O O   . ASP A 1 174 ? -18.77720 11.34486  -28.86324 1.000 5.44455  ? 176 ASP A O   1 
ATOM   1316 C CB  . ASP A 1 174 ? -16.06979 13.04927  -30.38861 1.000 4.51934  ? 176 ASP A CB  1 
ATOM   1317 C CG  . ASP A 1 174 ? -17.11199 13.49555  -31.43752 1.000 10.52975 ? 176 ASP A CG  1 
ATOM   1318 O OD1 . ASP A 1 174 ? -18.33218 13.29150  -31.23472 1.000 9.63021  ? 176 ASP A OD1 1 
ATOM   1319 O OD2 . ASP A 1 174 ? -16.70392 14.07145  -32.47029 1.000 8.92421  ? 176 ASP A OD2 1 
ATOM   1320 N N   . LEU A 1 175 ? -17.76413 13.11006  -27.91862 1.000 2.95818  ? 177 LEU A N   1 
ATOM   1321 C CA  . LEU A 1 175 ? -18.89532 13.39494  -27.04580 1.000 5.86896  ? 177 LEU A CA  1 
ATOM   1322 C C   . LEU A 1 175 ? -19.96626 14.22481  -27.74212 1.000 6.25127  ? 177 LEU A C   1 
ATOM   1323 O O   . LEU A 1 175 ? -20.93338 14.63665  -27.09497 1.000 7.29291  ? 177 LEU A O   1 
ATOM   1324 C CB  . LEU A 1 175 ? -18.43118 14.08817  -25.75078 1.000 3.09629  ? 177 LEU A CB  1 
ATOM   1325 C CG  . LEU A 1 175 ? -18.10023 13.09561  -24.63620 1.000 4.16190  ? 177 LEU A CG  1 
ATOM   1326 C CD1 . LEU A 1 175 ? -19.32437 12.26686  -24.35590 1.000 5.42498  ? 177 LEU A CD1 1 
ATOM   1327 C CD2 . LEU A 1 175 ? -16.92802 12.17359  -25.04606 1.000 3.93889  ? 177 LEU A CD2 1 
ATOM   1328 N N   . GLU A 1 176 ? -19.80308 14.48457  -29.03729 1.000 8.14146  ? 178 GLU A N   1 
ATOM   1329 C CA  . GLU A 1 176 ? -20.87470 14.95782  -29.89235 1.000 10.22734 ? 178 GLU A CA  1 
ATOM   1330 C C   . GLU A 1 176 ? -21.50808 13.82278  -30.68388 1.000 10.42957 ? 178 GLU A C   1 
ATOM   1331 O O   . GLU A 1 176 ? -22.36789 14.07550  -31.53751 1.000 9.71897  ? 178 GLU A O   1 
ATOM   1332 C CB  . GLU A 1 176 ? -20.36702 16.05555  -30.82491 1.000 10.83439 ? 178 GLU A CB  1 
ATOM   1333 C CG  . GLU A 1 176 ? -20.04570 17.34793  -30.06922 1.000 17.75987 ? 178 GLU A CG  1 
ATOM   1334 C CD  . GLU A 1 176 ? -19.56379 18.46635  -30.97027 1.000 27.57058 ? 178 GLU A CD  1 
ATOM   1335 O OE1 . GLU A 1 176 ? -20.00205 19.61577  -30.75629 1.000 36.69975 ? 178 GLU A OE1 1 
ATOM   1336 O OE2 . GLU A 1 176 ? -18.75321 18.20185  -31.88807 1.000 33.35236 ? 178 GLU A OE2 1 
ATOM   1337 N N   . GLY A 1 177 ? -21.11837 12.57865  -30.40602 1.000 6.20140  ? 179 GLY A N   1 
ATOM   1338 C CA  . GLY A 1 177 ? -21.78367 11.43034  -30.98685 1.000 4.90721  ? 179 GLY A CA  1 
ATOM   1339 C C   . GLY A 1 177 ? -21.29321 10.98690  -32.34770 1.000 6.07059  ? 179 GLY A C   1 
ATOM   1340 O O   . GLY A 1 177 ? -21.88618 10.06978  -32.92281 1.000 7.99271  ? 179 GLY A O   1 
ATOM   1341 N N   . ASN A 1 178 ? -20.23932 11.59748  -32.88233 1.000 8.05521  ? 180 ASN A N   1 
ATOM   1342 C CA  . ASN A 1 178 ? -19.72148 11.23566  -34.19756 1.000 8.21145  ? 180 ASN A CA  1 
ATOM   1343 C C   . ASN A 1 178 ? -18.63593 10.18069  -34.05012 1.000 6.99149  ? 180 ASN A C   1 
ATOM   1344 O O   . ASN A 1 178 ? -17.66856 10.37340  -33.30811 1.000 5.06303  ? 180 ASN A O   1 
ATOM   1345 C CB  . ASN A 1 178 ? -19.15293 12.45882  -34.91265 1.000 8.39335  ? 180 ASN A CB  1 
ATOM   1346 C CG  . ASN A 1 178 ? -20.22885 13.40500  -35.39365 1.000 8.18988  ? 180 ASN A CG  1 
ATOM   1347 O OD1 . ASN A 1 178 ? -21.17057 13.00099  -36.06393 1.000 15.98935 ? 180 ASN A OD1 1 
ATOM   1348 N ND2 . ASN A 1 178 ? -20.08657 14.67274  -35.05962 1.000 11.23602 ? 180 ASN A ND2 1 
ATOM   1349 N N   . PHE A 1 179 ? -18.78549 9.08080   -34.77350 1.000 8.32640  ? 181 PHE A N   1 
ATOM   1350 C CA  . PHE A 1 179 ? -17.80175 8.01770   -34.69850 1.000 5.17438  ? 181 PHE A CA  1 
ATOM   1351 C C   . PHE A 1 179 ? -16.43451 8.49207   -35.18026 1.000 7.09858  ? 181 PHE A C   1 
ATOM   1352 O O   . PHE A 1 179 ? -16.31672 9.34054   -36.07149 1.000 4.35854  ? 181 PHE A O   1 
ATOM   1353 C CB  . PHE A 1 179 ? -18.25112 6.80779   -35.51662 1.000 5.11426  ? 181 PHE A CB  1 
ATOM   1354 C CG  . PHE A 1 179 ? -18.89658 5.72088   -34.68416 1.000 7.00728  ? 181 PHE A CG  1 
ATOM   1355 C CD1 . PHE A 1 179 ? -20.27624 5.73514   -34.44611 1.000 5.94360  ? 181 PHE A CD1 1 
ATOM   1356 C CD2 . PHE A 1 179 ? -18.12978 4.69621   -34.13663 1.000 3.93186  ? 181 PHE A CD2 1 
ATOM   1357 C CE1 . PHE A 1 179 ? -20.87041 4.74563   -33.67116 1.000 8.05745  ? 181 PHE A CE1 1 
ATOM   1358 C CE2 . PHE A 1 179 ? -18.70940 3.69907   -33.36449 1.000 5.60238  ? 181 PHE A CE2 1 
ATOM   1359 C CZ  . PHE A 1 179 ? -20.07745 3.71571   -33.12410 1.000 5.44156  ? 181 PHE A CZ  1 
ATOM   1360 N N   . TYR A 1 180 ? -15.39987 7.96282   -34.53905 1.000 4.03229  ? 182 TYR A N   1 
ATOM   1361 C CA  . TYR A 1 180 ? -14.06167 7.95311   -35.11069 1.000 6.59804  ? 182 TYR A CA  1 
ATOM   1362 C C   . TYR A 1 180 ? -14.02708 6.84943   -36.16009 1.000 4.37157  ? 182 TYR A C   1 
ATOM   1363 O O   . TYR A 1 180 ? -14.37825 5.70051   -35.86732 1.000 5.56170  ? 182 TYR A O   1 
ATOM   1364 C CB  . TYR A 1 180 ? -13.01490 7.71731   -34.01569 1.000 4.34539  ? 182 TYR A CB  1 
ATOM   1365 C CG  . TYR A 1 180 ? -12.84280 8.87723   -33.03171 1.000 6.08173  ? 182 TYR A CG  1 
ATOM   1366 C CD1 . TYR A 1 180 ? -12.09686 10.00428  -33.38273 1.000 7.26979  ? 182 TYR A CD1 1 
ATOM   1367 C CD2 . TYR A 1 180 ? -13.41657 8.84038   -31.74826 1.000 4.24182  ? 182 TYR A CD2 1 
ATOM   1368 C CE1 . TYR A 1 180 ? -11.92827 11.06783  -32.50287 1.000 3.56005  ? 182 TYR A CE1 1 
ATOM   1369 C CE2 . TYR A 1 180 ? -13.24482 9.90463   -30.85180 1.000 2.38435  ? 182 TYR A CE2 1 
ATOM   1370 C CZ  . TYR A 1 180 ? -12.49233 11.01500  -31.24510 1.000 3.89815  ? 182 TYR A CZ  1 
ATOM   1371 O OH  . TYR A 1 180 ? -12.31155 12.09128  -30.40166 1.000 3.83019  ? 182 TYR A OH  1 
ATOM   1372 N N   . GLY A 1 181 ? -13.65046 7.19539   -37.38376 1.000 4.60755  ? 183 GLY A N   1 
ATOM   1373 C CA  . GLY A 1 181 ? -13.55590 6.21912   -38.44229 1.000 6.41538  ? 183 GLY A CA  1 
ATOM   1374 C C   . GLY A 1 181 ? -14.89127 5.89919   -39.08728 1.000 14.46356 ? 183 GLY A C   1 
ATOM   1375 O O   . GLY A 1 181 ? -15.90426 6.57968   -38.86842 1.000 11.57949 ? 183 GLY A O   1 
ATOM   1376 N N   . PRO A 1 182 ? -14.91062 4.84797   -39.90924 1.000 9.56878  ? 184 PRO A N   1 
ATOM   1377 C CA  . PRO A 1 182 ? -16.12244 4.53316   -40.67448 1.000 10.48583 ? 184 PRO A CA  1 
ATOM   1378 C C   . PRO A 1 182 ? -17.01696 3.49424   -40.01751 1.000 16.86220 ? 184 PRO A C   1 
ATOM   1379 O O   . PRO A 1 182 ? -17.74642 2.79633   -40.72249 1.000 21.88343 ? 184 PRO A O   1 
ATOM   1380 C CB  . PRO A 1 182 ? -15.56261 4.00918   -41.99979 1.000 13.29301 ? 184 PRO A CB  1 
ATOM   1381 C CG  . PRO A 1 182 ? -14.26097 3.34194   -41.59698 1.000 10.26403 ? 184 PRO A CG  1 
ATOM   1382 C CD  . PRO A 1 182 ? -13.71401 4.15908   -40.43725 1.000 11.67504 ? 184 PRO A CD  1 
ATOM   1383 N N   . PHE A 1 183 ? -16.99577 3.37479   -38.69393 1.000 10.03186 ? 185 PHE A N   1 
ATOM   1384 C CA  . PHE A 1 183 ? -17.79611 2.34302   -38.05821 1.000 11.36766 ? 185 PHE A CA  1 
ATOM   1385 C C   . PHE A 1 183 ? -19.18581 2.87480   -37.70779 1.000 8.33083  ? 185 PHE A C   1 
ATOM   1386 O O   . PHE A 1 183 ? -19.40771 4.08547   -37.60702 1.000 5.61243  ? 185 PHE A O   1 
ATOM   1387 C CB  . PHE A 1 183 ? -17.07572 1.80022   -36.82297 1.000 8.87968  ? 185 PHE A CB  1 
ATOM   1388 C CG  . PHE A 1 183 ? -15.65774 1.44230   -37.09852 1.000 11.69607 ? 185 PHE A CG  1 
ATOM   1389 C CD1 . PHE A 1 183 ? -15.35527 0.36703   -37.93036 1.000 10.95762 ? 185 PHE A CD1 1 
ATOM   1390 C CD2 . PHE A 1 183 ? -14.61754 2.20509   -36.57700 1.000 10.40213 ? 185 PHE A CD2 1 
ATOM   1391 C CE1 . PHE A 1 183 ? -14.02771 0.04638   -38.22141 1.000 10.43644 ? 185 PHE A CE1 1 
ATOM   1392 C CE2 . PHE A 1 183 ? -13.29320 1.88524   -36.87383 1.000 9.82958  ? 185 PHE A CE2 1 
ATOM   1393 C CZ  . PHE A 1 183 ? -13.00873 0.80644   -37.69417 1.000 5.16673  ? 185 PHE A CZ  1 
ATOM   1394 N N   . VAL A 1 184 ? -20.12516 1.94058   -37.54448 1.000 7.27095  ? 186 VAL A N   1 
ATOM   1395 C CA  . VAL A 1 184 ? -21.52358 2.23971   -37.25507 1.000 10.89158 ? 186 VAL A CA  1 
ATOM   1396 C C   . VAL A 1 184 ? -21.97828 1.42666   -36.04686 1.000 10.22146 ? 186 VAL A C   1 
ATOM   1397 O O   . VAL A 1 184 ? -21.44523 0.34588   -35.77183 1.000 10.63390 ? 186 VAL A O   1 
ATOM   1398 C CB  . VAL A 1 184 ? -22.42204 1.94698   -38.47891 1.000 11.52227 ? 186 VAL A CB  1 
ATOM   1399 C CG1 . VAL A 1 184 ? -22.07653 2.87397   -39.60847 1.000 8.92027  ? 186 VAL A CG1 1 
ATOM   1400 C CG2 . VAL A 1 184 ? -22.25080 0.50917   -38.92230 1.000 13.28948 ? 186 VAL A CG2 1 
ATOM   1401 N N   . ASP A 1 185 ? -22.99336 1.93993   -35.33003 1.000 11.05394 ? 187 ASP A N   1 
ATOM   1402 C CA  . ASP A 1 185 ? -23.45910 1.29746   -34.09314 1.000 10.41748 ? 187 ASP A CA  1 
ATOM   1403 C C   . ASP A 1 185 ? -24.60078 0.34126   -34.43248 1.000 14.20137 ? 187 ASP A C   1 
ATOM   1404 O O   . ASP A 1 185 ? -25.79121 0.58540   -34.18446 1.000 11.18195 ? 187 ASP A O   1 
ATOM   1405 C CB  . ASP A 1 185 ? -23.84273 2.33028   -33.03576 1.000 9.49281  ? 187 ASP A CB  1 
ATOM   1406 C CG  . ASP A 1 185 ? -24.84927 3.36211   -33.53208 1.000 7.19880  ? 187 ASP A CG  1 
ATOM   1407 O OD1 . ASP A 1 185 ? -25.23343 3.32692   -34.71757 1.000 7.51981  ? 187 ASP A OD1 1 
ATOM   1408 O OD2 . ASP A 1 185 ? -25.24604 4.22506   -32.72578 1.000 6.31190  ? 187 ASP A OD2 1 
ATOM   1409 N N   . ARG A 1 186 ? -24.18812 -0.82377  -34.91305 1.000 13.99299 ? 188 ARG A N   1 
ATOM   1410 C CA  . ARG A 1 186 ? -25.01709 -1.71025  -35.70422 1.000 19.01893 ? 188 ARG A CA  1 
ATOM   1411 C C   . ARG A 1 186 ? -24.27787 -3.03979  -35.72442 1.000 18.89116 ? 188 ARG A C   1 
ATOM   1412 O O   . ARG A 1 186 ? -23.07357 -3.05223  -35.99122 1.000 12.25236 ? 188 ARG A O   1 
ATOM   1413 C CB  . ARG A 1 186 ? -25.14568 -1.12936  -37.12399 1.000 20.27467 ? 188 ARG A CB  1 
ATOM   1414 C CG  . ARG A 1 186 ? -26.39601 -1.38630  -37.89256 1.000 17.71082 ? 188 ARG A CG  1 
ATOM   1415 C CD  . ARG A 1 186 ? -26.32959 -0.69250  -39.27105 1.000 11.87159 ? 188 ARG A CD  1 
ATOM   1416 N NE  . ARG A 1 186 ? -26.70907 -1.66643  -40.28313 1.000 21.03888 ? 188 ARG A NE  1 
ATOM   1417 C CZ  . ARG A 1 186 ? -26.20469 -1.72329  -41.51220 1.000 29.22902 ? 188 ARG A CZ  1 
ATOM   1418 N NH1 . ARG A 1 186 ? -25.31572 -0.82511  -41.91971 1.000 25.74551 ? 188 ARG A NH1 1 
ATOM   1419 N NH2 . ARG A 1 186 ? -26.61705 -2.66973  -42.34426 1.000 20.72168 ? 188 ARG A NH2 1 
ATOM   1420 N N   . GLN A 1 187 ? -24.96300 -4.14395  -35.42552 1.000 15.94104 ? 189 GLN A N   1 
ATOM   1421 C CA  . GLN A 1 187 ? -24.35009 -5.44485  -35.66660 1.000 17.80978 ? 189 GLN A CA  1 
ATOM   1422 C C   . GLN A 1 187 ? -24.23241 -5.65321  -37.16844 1.000 21.88781 ? 189 GLN A C   1 
ATOM   1423 O O   . GLN A 1 187 ? -25.24127 -5.68302  -37.88324 1.000 20.87603 ? 189 GLN A O   1 
ATOM   1424 C CB  . GLN A 1 187 ? -25.15380 -6.57539  -35.03648 1.000 20.33246 ? 189 GLN A CB  1 
ATOM   1425 C CG  . GLN A 1 187 ? -24.45616 -7.92750  -35.17897 1.000 18.07516 ? 189 GLN A CG  1 
ATOM   1426 C CD  . GLN A 1 187 ? -25.36372 -9.10268  -34.86977 1.000 24.53472 ? 189 GLN A CD  1 
ATOM   1427 O OE1 . GLN A 1 187 ? -26.19101 -9.04635  -33.96311 1.000 22.75087 ? 189 GLN A OE1 1 
ATOM   1428 N NE2 . GLN A 1 187 ? -25.21397 -10.17864 -35.63186 1.000 27.26876 ? 189 GLN A NE2 1 
ATOM   1429 N N   . THR A 1 188 ? -23.00429 -5.79464  -37.64043 1.000 20.57053 ? 190 THR A N   1 
ATOM   1430 C CA  . THR A 1 188 ? -22.71036 -5.74634  -39.06269 1.000 21.45221 ? 190 THR A CA  1 
ATOM   1431 C C   . THR A 1 188 ? -21.35558 -6.40721  -39.27638 1.000 26.16603 ? 190 THR A C   1 
ATOM   1432 O O   . THR A 1 188 ? -20.70658 -6.85057  -38.32518 1.000 30.46670 ? 190 THR A O   1 
ATOM   1433 C CB  . THR A 1 188 ? -22.73277 -4.30492  -39.56188 1.000 22.26942 ? 190 THR A CB  1 
ATOM   1434 O OG1 . THR A 1 188 ? -22.99848 -4.28530  -40.96906 1.000 36.85099 ? 190 THR A OG1 1 
ATOM   1435 C CG2 . THR A 1 188 ? -21.39333 -3.63934  -39.28038 1.000 24.12061 ? 190 THR A CG2 1 
ATOM   1436 N N   . ALA A 1 189 ? -20.93054 -6.47907  -40.53662 1.000 27.18989 ? 191 ALA A N   1 
ATOM   1437 C CA  . ALA A 1 189 ? -19.71861 -7.19891  -40.89927 1.000 27.52882 ? 191 ALA A CA  1 
ATOM   1438 C C   . ALA A 1 189 ? -18.46746 -6.32985  -40.84703 1.000 29.53996 ? 191 ALA A C   1 
ATOM   1439 O O   . ALA A 1 189 ? -17.44745 -6.70518  -41.43403 1.000 35.47179 ? 191 ALA A O   1 
ATOM   1440 C CB  . ALA A 1 189 ? -19.86097 -7.80412  -42.29868 1.000 24.24128 ? 191 ALA A CB  1 
ATOM   1441 N N   . GLN A 1 190 ? -18.51270 -5.19133  -40.15923 1.000 25.79863 ? 192 GLN A N   1 
ATOM   1442 C CA  . GLN A 1 190 ? -17.44190 -4.21066  -40.28636 1.000 25.96674 ? 192 GLN A CA  1 
ATOM   1443 C C   . GLN A 1 190 ? -16.15907 -4.70907  -39.62705 1.000 20.14836 ? 192 GLN A C   1 
ATOM   1444 O O   . GLN A 1 190 ? -16.18359 -5.40713  -38.61003 1.000 21.07726 ? 192 GLN A O   1 
ATOM   1445 C CB  . GLN A 1 190 ? -17.86142 -2.86479  -39.68456 1.000 18.51352 ? 192 GLN A CB  1 
ATOM   1446 C CG  . GLN A 1 190 ? -18.17329 -2.93210  -38.21107 1.000 17.90572 ? 192 GLN A CG  1 
ATOM   1447 C CD  . GLN A 1 190 ? -18.96468 -1.73585  -37.70997 1.000 15.36859 ? 192 GLN A CD  1 
ATOM   1448 O OE1 . GLN A 1 190 ? -19.08472 -0.71444  -38.39077 1.000 13.69631 ? 192 GLN A OE1 1 
ATOM   1449 N NE2 . GLN A 1 190 ? -19.49813 -1.85548  -36.50021 1.000 13.88163 ? 192 GLN A NE2 1 
ATOM   1450 N N   . ALA A 1 191 ? -15.02763 -4.35068  -40.23311 1.000 23.86496 ? 193 ALA A N   1 
ATOM   1451 C CA  . ALA A 1 191 ? -13.71568 -4.69634  -39.70103 1.000 20.70500 ? 193 ALA A CA  1 
ATOM   1452 C C   . ALA A 1 191 ? -12.79625 -3.49028  -39.78824 1.000 14.91089 ? 193 ALA A C   1 
ATOM   1453 O O   . ALA A 1 191 ? -12.92139 -2.64202  -40.67904 1.000 14.68422 ? 193 ALA A O   1 
ATOM   1454 C CB  . ALA A 1 191 ? -13.07771 -5.87866  -40.43953 1.000 15.87895 ? 193 ALA A CB  1 
ATOM   1455 N N   . ALA A 1 192 ? -11.87260 -3.42523  -38.83818 1.000 20.63656 ? 194 ALA A N   1 
ATOM   1456 C CA  . ALA A 1 192 ? -10.86138 -2.38107  -38.84106 1.000 15.75231 ? 194 ALA A CA  1 
ATOM   1457 C C   . ALA A 1 192 ? -9.93121  -2.57799  -40.02621 1.000 19.40028 ? 194 ALA A C   1 
ATOM   1458 O O   . ALA A 1 192 ? -9.45663  -3.69452  -40.26964 1.000 16.38320 ? 194 ALA A O   1 
ATOM   1459 C CB  . ALA A 1 192 ? -10.07946 -2.41869  -37.53308 1.000 18.80602 ? 194 ALA A CB  1 
ATOM   1460 N N   . GLY A 1 193 ? -9.69593  -1.50451  -40.77817 1.000 18.96155 ? 195 GLY A N   1 
ATOM   1461 C CA  . GLY A 1 193 ? -8.73745  -1.55262  -41.85713 1.000 13.17688 ? 195 GLY A CA  1 
ATOM   1462 C C   . GLY A 1 193 ? -7.32435  -1.79360  -41.34316 1.000 16.17902 ? 195 GLY A C   1 
ATOM   1463 O O   . GLY A 1 193 ? -7.07462  -2.01082  -40.15701 1.000 15.47589 ? 195 GLY A O   1 
ATOM   1464 N N   . THR A 1 194 ? -6.38062  -1.74821  -42.27745 1.000 19.71562 ? 196 THR A N   1 
ATOM   1465 C CA  . THR A 1 194 ? -4.97998  -1.95865  -41.93299 1.000 16.45413 ? 196 THR A CA  1 
ATOM   1466 C C   . THR A 1 194 ? -4.47754  -0.81927  -41.05339 1.000 16.82656 ? 196 THR A C   1 
ATOM   1467 O O   . THR A 1 194 ? -4.84195  0.34344   -41.24498 1.000 18.60157 ? 196 THR A O   1 
ATOM   1468 C CB  . THR A 1 194 ? -4.12535  -2.07756  -43.20640 1.000 14.89207 ? 196 THR A CB  1 
ATOM   1469 O OG1 . THR A 1 194 ? -2.73350  -1.96419  -42.86389 1.000 30.58155 ? 196 THR A OG1 1 
ATOM   1470 C CG2 . THR A 1 194 ? -4.48637  -1.00273  -44.19247 1.000 14.17870 ? 196 THR A CG2 1 
ATOM   1471 N N   . ASP A 1 195 ? -3.64144  -1.16000  -40.08057 1.000 15.14470 ? 197 ASP A N   1 
ATOM   1472 C CA  . ASP A 1 195 ? -3.13850  -0.21125  -39.10200 1.000 18.67145 ? 197 ASP A CA  1 
ATOM   1473 C C   . ASP A 1 195 ? -1.63505  -0.01511  -39.29738 1.000 17.66667 ? 197 ASP A C   1 
ATOM   1474 O O   . ASP A 1 195 ? -0.92916  -0.94357  -39.69906 1.000 16.01012 ? 197 ASP A O   1 
ATOM   1475 C CB  . ASP A 1 195 ? -3.44051  -0.71347  -37.68459 1.000 13.89046 ? 197 ASP A CB  1 
ATOM   1476 C CG  . ASP A 1 195 ? -3.16000  0.32596   -36.62042 1.000 15.70553 ? 197 ASP A CG  1 
ATOM   1477 O OD1 . ASP A 1 195 ? -3.34246  1.53026   -36.91405 1.000 17.19236 ? 197 ASP A OD1 1 
ATOM   1478 O OD2 . ASP A 1 195 ? -2.76784  -0.06096  -35.49036 1.000 10.60139 ? 197 ASP A OD2 1 
ATOM   1479 N N   . THR A 1 196 ? -1.15079  1.20186   -39.02519 1.000 12.94051 ? 198 THR A N   1 
ATOM   1480 C CA  . THR A 1 196 ? 0.26356   1.53446   -39.14405 1.000 8.89326  ? 198 THR A CA  1 
ATOM   1481 C C   . THR A 1 196 ? 0.86428   1.84112   -37.77955 1.000 10.38966 ? 198 THR A C   1 
ATOM   1482 O O   . THR A 1 196 ? 0.16557   2.26402   -36.85162 1.000 5.77241  ? 198 THR A O   1 
ATOM   1483 C CB  . THR A 1 196 ? 0.51407   2.74672   -40.06835 1.000 13.53149 ? 198 THR A CB  1 
ATOM   1484 O OG1 . THR A 1 196 ? -0.24201  3.88674   -39.62831 1.000 7.75808  ? 198 THR A OG1 1 
ATOM   1485 C CG2 . THR A 1 196 ? 0.18568   2.43198   -41.53692 1.000 8.75053  ? 198 THR A CG2 1 
ATOM   1486 N N   . THR A 1 197 ? 2.18273   1.63598   -37.66718 1.000 5.09431  ? 199 THR A N   1 
ATOM   1487 C CA  . THR A 1 197 ? 2.89883   2.11104   -36.49448 1.000 2.32651  ? 199 THR A CA  1 
ATOM   1488 C C   . THR A 1 197 ? 2.98964   3.63286   -36.54615 1.000 3.19118  ? 199 THR A C   1 
ATOM   1489 O O   . THR A 1 197 ? 3.09851   4.22486   -37.62313 1.000 4.50453  ? 199 THR A O   1 
ATOM   1490 C CB  . THR A 1 197 ? 4.28246   1.46429   -36.41744 1.000 4.45693  ? 199 THR A CB  1 
ATOM   1491 O OG1 . THR A 1 197 ? 4.12797   0.04437   -36.43563 1.000 5.15076  ? 199 THR A OG1 1 
ATOM   1492 C CG2 . THR A 1 197 ? 5.01742   1.86049   -35.13895 1.000 2.77672  ? 199 THR A CG2 1 
ATOM   1493 N N   . ILE A 1 198 ? 2.90923   4.27074   -35.37812 1.000 1.13902  ? 200 ILE A N   1 
ATOM   1494 C CA  . ILE A 1 198 ? 2.74980   5.72880   -35.28753 1.000 2.30520  ? 200 ILE A CA  1 
ATOM   1495 C C   . ILE A 1 198 ? 4.15998   6.31718   -35.19569 1.000 3.75235  ? 200 ILE A C   1 
ATOM   1496 O O   . ILE A 1 198 ? 4.73487   6.47781   -34.11426 1.000 1.49939  ? 200 ILE A O   1 
ATOM   1497 C CB  . ILE A 1 198 ? 1.85339   6.12498   -34.10930 1.000 5.44272  ? 200 ILE A CB  1 
ATOM   1498 C CG1 . ILE A 1 198 ? 0.51388   5.36722   -34.17820 1.000 4.38436  ? 200 ILE A CG1 1 
ATOM   1499 C CG2 . ILE A 1 198 ? 1.59392   7.62481   -34.06550 1.000 2.77096  ? 200 ILE A CG2 1 
ATOM   1500 C CD1 . ILE A 1 198 ? -0.36660  5.55673   -32.95292 1.000 5.15784  ? 200 ILE A CD1 1 
ATOM   1501 N N   . THR A 1 199 ? 4.71404   6.66445   -36.35958 1.000 3.44417  ? 201 THR A N   1 
ATOM   1502 C CA  . THR A 1 199 ? 6.13579   6.98768   -36.45849 1.000 4.70188  ? 201 THR A CA  1 
ATOM   1503 C C   . THR A 1 199 ? 6.52125   8.16125   -35.56841 1.000 4.44065  ? 201 THR A C   1 
ATOM   1504 O O   . THR A 1 199 ? 7.56235   8.12004   -34.89277 1.000 2.96802  ? 201 THR A O   1 
ATOM   1505 C CB  . THR A 1 199 ? 6.48710   7.28628   -37.91833 1.000 4.61207  ? 201 THR A CB  1 
ATOM   1506 O OG1 . THR A 1 199 ? 6.00732   6.21199   -38.73361 1.000 4.10920  ? 201 THR A OG1 1 
ATOM   1507 C CG2 . THR A 1 199 ? 7.99889   7.47154   -38.09835 1.000 1.96265  ? 201 THR A CG2 1 
ATOM   1508 N N   . VAL A 1 200 ? 5.70158   9.22036   -35.55428 1.000 3.20392  ? 202 VAL A N   1 
ATOM   1509 C CA  . VAL A 1 200 ? 6.06225   10.39377  -34.76889 1.000 2.85035  ? 202 VAL A CA  1 
ATOM   1510 C C   . VAL A 1 200 ? 6.16729   10.03037  -33.29540 1.000 6.89221  ? 202 VAL A C   1 
ATOM   1511 O O   . VAL A 1 200 ? 7.04328   10.54399  -32.58396 1.000 4.08961  ? 202 VAL A O   1 
ATOM   1512 C CB  . VAL A 1 200 ? 5.08196   11.56249  -35.02125 1.000 6.04799  ? 202 VAL A CB  1 
ATOM   1513 C CG1 . VAL A 1 200 ? 3.66660   11.27162  -34.48530 1.000 4.02736  ? 202 VAL A CG1 1 
ATOM   1514 C CG2 . VAL A 1 200 ? 5.64097   12.85523  -34.41210 1.000 5.58477  ? 202 VAL A CG2 1 
ATOM   1515 N N   . ASN A 1 201 ? 5.33961   9.08669   -32.83213 1.000 4.78153  ? 203 ASN A N   1 
ATOM   1516 C CA  . ASN A 1 201 ? 5.37872   8.69860   -31.42466 1.000 5.90613  ? 203 ASN A CA  1 
ATOM   1517 C C   . ASN A 1 201 ? 6.63062   7.89495   -31.11482 1.000 4.43925  ? 203 ASN A C   1 
ATOM   1518 O O   . ASN A 1 201 ? 7.26336   8.10408   -30.07147 1.000 3.08199  ? 203 ASN A O   1 
ATOM   1519 C CB  . ASN A 1 201 ? 4.11885   7.89971   -31.06183 1.000 3.67037  ? 203 ASN A CB  1 
ATOM   1520 C CG  . ASN A 1 201 ? 2.89835   8.78262   -30.84915 1.000 5.12665  ? 203 ASN A CG  1 
ATOM   1521 O OD1 . ASN A 1 201 ? 2.98868   10.00784  -30.89160 1.000 4.80059  ? 203 ASN A OD1 1 
ATOM   1522 N ND2 . ASN A 1 201 ? 1.74643   8.15827   -30.60084 1.000 3.74505  ? 203 ASN A ND2 1 
ATOM   1523 N N   . VAL A 1 202 ? 6.99534   6.96246   -32.00555 1.000 6.25565  ? 204 VAL A N   1 
ATOM   1524 C CA  . VAL A 1 202 ? 8.21519   6.17798   -31.81583 1.000 6.77093  ? 204 VAL A CA  1 
ATOM   1525 C C   . VAL A 1 202 ? 9.42461   7.09708   -31.70130 1.000 5.92173  ? 204 VAL A C   1 
ATOM   1526 O O   . VAL A 1 202 ? 10.32808  6.86646   -30.88687 1.000 5.30634  ? 204 VAL A O   1 
ATOM   1527 C CB  . VAL A 1 202 ? 8.39989   5.16391   -32.96218 1.000 8.24415  ? 204 VAL A CB  1 
ATOM   1528 C CG1 . VAL A 1 202 ? 9.75719   4.49295   -32.84992 1.000 4.15710  ? 204 VAL A CG1 1 
ATOM   1529 C CG2 . VAL A 1 202 ? 7.29109   4.12704   -32.96640 1.000 3.38832  ? 204 VAL A CG2 1 
ATOM   1530 N N   . LEU A 1 203 ? 9.45540   8.15614   -32.51141 1.000 5.22109  ? 205 LEU A N   1 
ATOM   1531 C CA  . LEU A 1 203 ? 10.58221  9.07722   -32.48573 1.000 5.36667  ? 205 LEU A CA  1 
ATOM   1532 C C   . LEU A 1 203 ? 10.60920  9.85273   -31.18138 1.000 7.07272  ? 205 LEU A C   1 
ATOM   1533 O O   . LEU A 1 203 ? 11.68498  10.09811  -30.62386 1.000 2.56019  ? 205 LEU A O   1 
ATOM   1534 C CB  . LEU A 1 203 ? 10.50759  10.02394  -33.68326 1.000 3.39965  ? 205 LEU A CB  1 
ATOM   1535 C CG  . LEU A 1 203 ? 10.87230  9.38120   -35.02684 1.000 4.13492  ? 205 LEU A CG  1 
ATOM   1536 C CD1 . LEU A 1 203 ? 10.45359  10.29038  -36.17979 1.000 3.48240  ? 205 LEU A CD1 1 
ATOM   1537 C CD2 . LEU A 1 203 ? 12.39459  9.05290   -35.10741 1.000 4.87097  ? 205 LEU A CD2 1 
ATOM   1538 N N   . ALA A 1 204 ? 9.42713   10.24064  -30.68291 1.000 5.57965  ? 206 ALA A N   1 
ATOM   1539 C CA  . ALA A 1 204 ? 9.32488   10.89204  -29.37816 1.000 6.56048  ? 206 ALA A CA  1 
ATOM   1540 C C   . ALA A 1 204 ? 9.88189   10.00401  -28.27371 1.000 4.29288  ? 206 ALA A C   1 
ATOM   1541 O O   . ALA A 1 204 ? 10.56513  10.47992  -27.35543 1.000 6.65617  ? 206 ALA A O   1 
ATOM   1542 C CB  . ALA A 1 204 ? 7.85794   11.24937  -29.08549 1.000 5.73558  ? 206 ALA A CB  1 
ATOM   1543 N N   . TRP A 1 205 ? 9.61432   8.70437   -28.37130 1.000 2.94318  ? 207 TRP A N   1 
ATOM   1544 C CA  . TRP A 1 205 ? 10.02633  7.73485   -27.37258 1.000 5.17267  ? 207 TRP A CA  1 
ATOM   1545 C C   . TRP A 1 205 ? 11.53429  7.48728   -27.41852 1.000 8.91498  ? 207 TRP A C   1 
ATOM   1546 O O   . TRP A 1 205 ? 12.15954  7.24578   -26.37638 1.000 7.91564  ? 207 TRP A O   1 
ATOM   1547 C CB  . TRP A 1 205 ? 9.22097   6.46181   -27.62799 1.000 7.68254  ? 207 TRP A CB  1 
ATOM   1548 C CG  . TRP A 1 205 ? 9.48750   5.26353   -26.79146 1.000 9.22240  ? 207 TRP A CG  1 
ATOM   1549 C CD1 . TRP A 1 205 ? 9.05612   5.03368   -25.51550 1.000 13.20046 ? 207 TRP A CD1 1 
ATOM   1550 C CD2 . TRP A 1 205 ? 10.17862  4.07997   -27.20182 1.000 8.15074  ? 207 TRP A CD2 1 
ATOM   1551 N NE1 . TRP A 1 205 ? 9.46176   3.78533   -25.09886 1.000 10.31714 ? 207 TRP A NE1 1 
ATOM   1552 C CE2 . TRP A 1 205 ? 10.14749  3.17973   -26.11825 1.000 11.14463 ? 207 TRP A CE2 1 
ATOM   1553 C CE3 . TRP A 1 205 ? 10.83242  3.69647   -28.38209 1.000 12.05871 ? 207 TRP A CE3 1 
ATOM   1554 C CZ2 . TRP A 1 205 ? 10.74581  1.91808   -26.17666 1.000 16.06628 ? 207 TRP A CZ2 1 
ATOM   1555 C CZ3 . TRP A 1 205 ? 11.43407  2.43882   -28.43859 1.000 12.86390 ? 207 TRP A CZ3 1 
ATOM   1556 C CH2 . TRP A 1 205 ? 11.38198  1.56590   -27.34338 1.000 11.42763 ? 207 TRP A CH2 1 
ATOM   1557 N N   . LEU A 1 206 ? 12.13103  7.55083   -28.61059 1.000 6.64189  ? 208 LEU A N   1 
ATOM   1558 C CA  . LEU A 1 206 ? 13.58545  7.46276   -28.72516 1.000 7.91656  ? 208 LEU A CA  1 
ATOM   1559 C C   . LEU A 1 206 ? 14.26203  8.67656   -28.09858 1.000 7.41640  ? 208 LEU A C   1 
ATOM   1560 O O   . LEU A 1 206 ? 15.30106  8.53965   -27.43544 1.000 9.42432  ? 208 LEU A O   1 
ATOM   1561 C CB  . LEU A 1 206 ? 13.98403  7.30751   -30.19726 1.000 3.54235  ? 208 LEU A CB  1 
ATOM   1562 C CG  . LEU A 1 206 ? 13.58373  5.96774   -30.82825 1.000 5.44758  ? 208 LEU A CG  1 
ATOM   1563 C CD1 . LEU A 1 206 ? 13.97767  5.83973   -32.30684 1.000 5.67971  ? 208 LEU A CD1 1 
ATOM   1564 C CD2 . LEU A 1 206 ? 14.12832  4.79479   -30.03678 1.000 3.68375  ? 208 LEU A CD2 1 
ATOM   1565 N N   . TYR A 1 207 ? 13.69108  9.87377   -28.29728 1.000 6.46858  ? 209 TYR A N   1 
ATOM   1566 C CA  . TYR A 1 207 ? 14.21620  11.05807  -27.62392 1.000 7.41695  ? 209 TYR A CA  1 
ATOM   1567 C C   . TYR A 1 207 ? 14.10436  10.91342  -26.11440 1.000 9.08637  ? 209 TYR A C   1 
ATOM   1568 O O   . TYR A 1 207 ? 15.03065  11.27626  -25.37338 1.000 9.43869  ? 209 TYR A O   1 
ATOM   1569 C CB  . TYR A 1 207 ? 13.49358  12.31872  -28.10146 1.000 4.35067  ? 209 TYR A CB  1 
ATOM   1570 C CG  . TYR A 1 207 ? 14.00303  12.89639  -29.41418 1.000 5.44246  ? 209 TYR A CG  1 
ATOM   1571 C CD1 . TYR A 1 207 ? 15.23990  13.51795  -29.49283 1.000 7.96404  ? 209 TYR A CD1 1 
ATOM   1572 C CD2 . TYR A 1 207 ? 13.22657  12.84517  -30.57357 1.000 8.06756  ? 209 TYR A CD2 1 
ATOM   1573 C CE1 . TYR A 1 207 ? 15.70423  14.06109  -30.68687 1.000 9.48827  ? 209 TYR A CE1 1 
ATOM   1574 C CE2 . TYR A 1 207 ? 13.67819  13.37849  -31.76111 1.000 7.13316  ? 209 TYR A CE2 1 
ATOM   1575 C CZ  . TYR A 1 207 ? 14.91995  13.98912  -31.81340 1.000 11.30013 ? 209 TYR A CZ  1 
ATOM   1576 O OH  . TYR A 1 207 ? 15.37988  14.52418  -32.99736 1.000 10.72881 ? 209 TYR A OH  1 
ATOM   1577 N N   . ALA A 1 208 ? 12.98722  10.35393  -25.64382 1.000 9.08287  ? 210 ALA A N   1 
ATOM   1578 C CA  . ALA A 1 208 ? 12.82669  10.08758  -24.22044 1.000 10.82086 ? 210 ALA A CA  1 
ATOM   1579 C C   . ALA A 1 208 ? 13.89780  9.12838   -23.72096 1.000 10.65845 ? 210 ALA A C   1 
ATOM   1580 O O   . ALA A 1 208 ? 14.36219  9.24513   -22.58469 1.000 9.91425  ? 210 ALA A O   1 
ATOM   1581 C CB  . ALA A 1 208 ? 11.43354  9.52165   -23.94128 1.000 6.61376  ? 210 ALA A CB  1 
ATOM   1582 N N   . ALA A 1 209 ? 14.27091  8.14861   -24.54367 1.000 8.12336  ? 211 ALA A N   1 
ATOM   1583 C CA  . ALA A 1 209 ? 15.33775  7.23995   -24.15533 1.000 12.61474 ? 211 ALA A CA  1 
ATOM   1584 C C   . ALA A 1 209 ? 16.67383  7.97062   -24.07351 1.000 12.60684 ? 211 ALA A C   1 
ATOM   1585 O O   . ALA A 1 209 ? 17.49516  7.66803   -23.20293 1.000 16.33183 ? 211 ALA A O   1 
ATOM   1586 C CB  . ALA A 1 209 ? 15.41017  6.06652   -25.13078 1.000 10.50087 ? 211 ALA A CB  1 
ATOM   1587 N N   . VAL A 1 210 ? 16.90364  8.94737   -24.95856 1.000 13.97525 ? 212 VAL A N   1 
ATOM   1588 C CA  . VAL A 1 210 ? 18.13075  9.73750   -24.88047 1.000 13.13072 ? 212 VAL A CA  1 
ATOM   1589 C C   . VAL A 1 210 ? 18.10073  10.65037  -23.65819 1.000 13.61550 ? 212 VAL A C   1 
ATOM   1590 O O   . VAL A 1 210 ? 19.11220  10.81310  -22.96210 1.000 10.73131 ? 212 VAL A O   1 
ATOM   1591 C CB  . VAL A 1 210 ? 18.34782  10.54111  -26.17880 1.000 11.11797 ? 212 VAL A CB  1 
ATOM   1592 C CG1 . VAL A 1 210 ? 19.60061  11.43652  -26.05598 1.000 10.21805 ? 212 VAL A CG1 1 
ATOM   1593 C CG2 . VAL A 1 210 ? 18.47324  9.60409   -27.37795 1.000 6.88651  ? 212 VAL A CG2 1 
ATOM   1594 N N   . ILE A 1 211 ? 16.94726  11.27002  -23.39068 1.000 10.24521 ? 213 ILE A N   1 
ATOM   1595 C CA  . ILE A 1 211 ? 16.80499  12.16785  -22.24673 1.000 10.18964 ? 213 ILE A CA  1 
ATOM   1596 C C   . ILE A 1 211 ? 17.15724  11.43742  -20.96180 1.000 16.50539 ? 213 ILE A C   1 
ATOM   1597 O O   . ILE A 1 211 ? 17.86805  11.97217  -20.09886 1.000 15.21665 ? 213 ILE A O   1 
ATOM   1598 C CB  . ILE A 1 211 ? 15.37863  12.75573  -22.20434 1.000 15.17508 ? 213 ILE A CB  1 
ATOM   1599 C CG1 . ILE A 1 211 ? 15.27305  13.93599  -23.16841 1.000 12.56050 ? 213 ILE A CG1 1 
ATOM   1600 C CG2 . ILE A 1 211 ? 15.00922  13.20560  -20.79676 1.000 15.24885 ? 213 ILE A CG2 1 
ATOM   1601 C CD1 . ILE A 1 211 ? 13.90542  14.10413  -23.79933 1.000 12.65804 ? 213 ILE A CD1 1 
ATOM   1602 N N   . ASN A 1 212 ? 16.69437  10.19135  -20.82998 1.000 12.02610 ? 214 ASN A N   1 
ATOM   1603 C CA  . ASN A 1 212 ? 17.17663  9.29285   -19.79293 1.000 16.41871 ? 214 ASN A CA  1 
ATOM   1604 C C   . ASN A 1 212 ? 18.57288  8.77559   -20.15290 1.000 28.28385 ? 214 ASN A C   1 
ATOM   1605 O O   . ASN A 1 212 ? 19.41710  9.54599   -20.62938 1.000 27.07036 ? 214 ASN A O   1 
ATOM   1606 C CB  . ASN A 1 212 ? 16.15651  8.17707   -19.57919 1.000 13.47270 ? 214 ASN A CB  1 
ATOM   1607 C CG  . ASN A 1 212 ? 14.82810  8.72163   -19.05760 1.000 32.59459 ? 214 ASN A CG  1 
ATOM   1608 O OD1 . ASN A 1 212 ? 14.75538  9.24135   -17.94089 1.000 39.81699 ? 214 ASN A OD1 1 
ATOM   1609 N ND2 . ASN A 1 212 ? 13.78414  8.65047   -19.88346 1.000 35.13248 ? 214 ASN A ND2 1 
ATOM   1610 N N   . GLY A 1 213 ? 18.85452  7.49292   -19.94502 1.000 26.13151 ? 215 GLY A N   1 
ATOM   1611 C CA  . GLY A 1 213 ? 20.26077  7.12145   -20.01657 1.000 33.62427 ? 215 GLY A CA  1 
ATOM   1612 C C   . GLY A 1 213 ? 20.85329  6.63419   -21.33556 1.000 26.73087 ? 215 GLY A C   1 
ATOM   1613 O O   . GLY A 1 213 ? 22.08011  6.50515   -21.41046 1.000 26.37732 ? 215 GLY A O   1 
ATOM   1614 N N   . ASP A 1 214 ? 20.05474  6.36320   -22.36989 1.000 12.74126 ? 216 ASP A N   1 
ATOM   1615 C CA  . ASP A 1 214 ? 20.45971  5.47522   -23.45710 1.000 20.08152 ? 216 ASP A CA  1 
ATOM   1616 C C   . ASP A 1 214 ? 20.85209  6.25208   -24.70629 1.000 24.25943 ? 216 ASP A C   1 
ATOM   1617 O O   . ASP A 1 214 ? 20.06701  7.06856   -25.20466 1.000 18.34341 ? 216 ASP A O   1 
ATOM   1618 C CB  . ASP A 1 214 ? 19.33918  4.49856   -23.83075 1.000 25.86282 ? 216 ASP A CB  1 
ATOM   1619 C CG  . ASP A 1 214 ? 18.98418  3.52805   -22.71087 1.000 36.23736 ? 216 ASP A CG  1 
ATOM   1620 O OD1 . ASP A 1 214 ? 19.82829  3.29710   -21.81504 1.000 35.75208 ? 216 ASP A OD1 1 
ATOM   1621 O OD2 . ASP A 1 214 ? 17.84752  2.98586   -22.74117 1.000 43.36239 ? 216 ASP A OD2 1 
ATOM   1622 N N   . ARG A 1 215 ? 22.04658  5.95167   -25.24111 1.000 12.63984 ? 217 ARG A N   1 
ATOM   1623 C CA  . ARG A 1 215 ? 22.43082  6.38996   -26.57939 1.000 13.02083 ? 217 ARG A CA  1 
ATOM   1624 C C   . ARG A 1 215 ? 22.90177  5.24049   -27.45880 1.000 10.23248 ? 217 ARG A C   1 
ATOM   1625 O O   . ARG A 1 215 ? 23.42852  5.49690   -28.54514 1.000 10.41675 ? 217 ARG A O   1 
ATOM   1626 C CB  . ARG A 1 215 ? 23.53770  7.45393   -26.53253 1.000 10.79858 ? 217 ARG A CB  1 
ATOM   1627 C CG  . ARG A 1 215 ? 23.21402  8.65170   -25.67060 1.000 13.44896 ? 217 ARG A CG  1 
ATOM   1628 C CD  . ARG A 1 215 ? 24.36098  9.61270   -25.61993 1.000 12.02273 ? 217 ARG A CD  1 
ATOM   1629 N NE  . ARG A 1 215 ? 24.97144  9.77147   -26.93106 1.000 12.24592 ? 217 ARG A NE  1 
ATOM   1630 C CZ  . ARG A 1 215 ? 24.88891  10.87095  -27.67176 1.000 15.09113 ? 217 ARG A CZ  1 
ATOM   1631 N NH1 . ARG A 1 215 ? 25.47795  10.90882  -28.86091 1.000 7.84843  ? 217 ARG A NH1 1 
ATOM   1632 N NH2 . ARG A 1 215 ? 24.20489  11.92548  -27.23502 1.000 14.42723 ? 217 ARG A NH2 1 
ATOM   1633 N N   . TRP A 1 216 ? 22.72424  3.98201   -27.03525 1.000 9.88864  ? 218 TRP A N   1 
ATOM   1634 C CA  . TRP A 1 216 ? 23.34543  2.87999   -27.76635 1.000 8.90559  ? 218 TRP A CA  1 
ATOM   1635 C C   . TRP A 1 216 ? 22.79739  2.71261   -29.18690 1.000 11.07938 ? 218 TRP A C   1 
ATOM   1636 O O   . TRP A 1 216 ? 23.46510  2.07022   -30.00747 1.000 7.21759  ? 218 TRP A O   1 
ATOM   1637 C CB  . TRP A 1 216 ? 23.20582  1.55533   -26.99501 1.000 5.04209  ? 218 TRP A CB  1 
ATOM   1638 C CG  . TRP A 1 216 ? 21.79733  1.03915   -26.78134 1.000 9.16729  ? 218 TRP A CG  1 
ATOM   1639 C CD1 . TRP A 1 216 ? 21.06061  1.13831   -25.63085 1.000 13.16615 ? 218 TRP A CD1 1 
ATOM   1640 C CD2 . TRP A 1 216 ? 20.97058  0.31988   -27.71805 1.000 10.12943 ? 218 TRP A CD2 1 
ATOM   1641 N NE1 . TRP A 1 216 ? 19.84168  0.53769   -25.79377 1.000 14.06744 ? 218 TRP A NE1 1 
ATOM   1642 C CE2 . TRP A 1 216 ? 19.75374  0.03398   -27.06530 1.000 15.28852 ? 218 TRP A CE2 1 
ATOM   1643 C CE3 . TRP A 1 216 ? 21.13399  -0.09476  -29.04168 1.000 9.88779  ? 218 TRP A CE3 1 
ATOM   1644 C CZ2 . TRP A 1 216 ? 18.70938  -0.65357  -27.69398 1.000 14.52278 ? 218 TRP A CZ2 1 
ATOM   1645 C CZ3 . TRP A 1 216 ? 20.10694  -0.78509  -29.66135 1.000 12.47036 ? 218 TRP A CZ3 1 
ATOM   1646 C CH2 . TRP A 1 216 ? 18.90232  -1.04931  -28.99179 1.000 18.14696 ? 218 TRP A CH2 1 
ATOM   1647 N N   . PHE A 1 217 ? 21.61117  3.26722   -29.49867 1.000 4.30549  ? 219 PHE A N   1 
ATOM   1648 C CA  . PHE A 1 217 ? 20.97713  3.03420   -30.79233 1.000 5.45300  ? 219 PHE A CA  1 
ATOM   1649 C C   . PHE A 1 217 ? 21.32465  4.09626   -31.82532 1.000 4.48806  ? 219 PHE A C   1 
ATOM   1650 O O   . PHE A 1 217 ? 21.08261  3.88281   -33.01681 1.000 6.68505  ? 219 PHE A O   1 
ATOM   1651 C CB  . PHE A 1 217 ? 19.42767  2.95592   -30.63995 1.000 8.45096  ? 219 PHE A CB  1 
ATOM   1652 C CG  . PHE A 1 217 ? 18.86139  3.99519   -29.71262 1.000 4.01967  ? 219 PHE A CG  1 
ATOM   1653 C CD1 . PHE A 1 217 ? 18.55967  5.26982   -30.17761 1.000 2.68699  ? 219 PHE A CD1 1 
ATOM   1654 C CD2 . PHE A 1 217 ? 18.68246  3.71528   -28.36367 1.000 6.89513  ? 219 PHE A CD2 1 
ATOM   1655 C CE1 . PHE A 1 217 ? 18.06482  6.24173   -29.32063 1.000 3.48479  ? 219 PHE A CE1 1 
ATOM   1656 C CE2 . PHE A 1 217 ? 18.20408  4.68434   -27.49600 1.000 6.19687  ? 219 PHE A CE2 1 
ATOM   1657 C CZ  . PHE A 1 217 ? 17.89080  5.95419   -27.98095 1.000 6.01579  ? 219 PHE A CZ  1 
ATOM   1658 N N   . LEU A 1 218 ? 21.86410  5.23360   -31.40671 1.000 4.51330  ? 220 LEU A N   1 
ATOM   1659 C CA  . LEU A 1 218 ? 22.28372  6.25466   -32.35557 1.000 6.82734  ? 220 LEU A CA  1 
ATOM   1660 C C   . LEU A 1 218 ? 23.34312  5.71319   -33.32051 1.000 8.98397  ? 220 LEU A C   1 
ATOM   1661 O O   . LEU A 1 218 ? 24.00916  4.70390   -33.06023 1.000 5.69213  ? 220 LEU A O   1 
ATOM   1662 C CB  . LEU A 1 218 ? 22.84589  7.45861   -31.60489 1.000 9.51421  ? 220 LEU A CB  1 
ATOM   1663 C CG  . LEU A 1 218 ? 21.92100  8.02888   -30.53678 1.000 7.85187  ? 220 LEU A CG  1 
ATOM   1664 C CD1 . LEU A 1 218 ? 22.58395  9.20762   -29.85251 1.000 8.81719  ? 220 LEU A CD1 1 
ATOM   1665 C CD2 . LEU A 1 218 ? 20.59316  8.43309   -31.17465 1.000 7.20086  ? 220 LEU A CD2 1 
ATOM   1666 N N   . ASN A 1 219 ? 23.49348  6.39920   -34.45529 1.000 9.12785  ? 221 ASN A N   1 
ATOM   1667 C CA  . ASN A 1 219 ? 24.56303  6.10372   -35.39435 1.000 7.77940  ? 221 ASN A CA  1 
ATOM   1668 C C   . ASN A 1 219 ? 25.04754  7.41106   -36.00613 1.000 11.13558 ? 221 ASN A C   1 
ATOM   1669 O O   . ASN A 1 219 ? 24.50097  8.48359   -35.73823 1.000 7.20489  ? 221 ASN A O   1 
ATOM   1670 C CB  . ASN A 1 219 ? 24.13464  5.06993   -36.45049 1.000 5.78066  ? 221 ASN A CB  1 
ATOM   1671 C CG  . ASN A 1 219 ? 23.04787  5.55978   -37.39165 1.000 6.53365  ? 221 ASN A CG  1 
ATOM   1672 O OD1 . ASN A 1 219 ? 22.87442  6.74917   -37.63552 1.000 6.35689  ? 221 ASN A OD1 1 
ATOM   1673 N ND2 . ASN A 1 219 ? 22.34075  4.61046   -37.97463 1.000 6.95006  ? 221 ASN A ND2 1 
ATOM   1674 N N   . ARG A 1 220 ? 26.10188  7.32473   -36.81866 1.000 8.54207  ? 222 ARG A N   1 
ATOM   1675 C CA  . ARG A 1 220 ? 26.71275  8.50995   -37.39995 1.000 9.90088  ? 222 ARG A CA  1 
ATOM   1676 C C   . ARG A 1 220 ? 26.02565  8.96914   -38.68225 1.000 10.03290 ? 222 ARG A C   1 
ATOM   1677 O O   . ARG A 1 220 ? 26.51021  9.90145   -39.32618 1.000 12.58843 ? 222 ARG A O   1 
ATOM   1678 C CB  . ARG A 1 220 ? 28.20441  8.25732   -37.66824 1.000 17.66447 ? 222 ARG A CB  1 
ATOM   1679 C CG  . ARG A 1 220 ? 28.47468  7.17488   -38.71873 1.000 17.73748 ? 222 ARG A CG  1 
ATOM   1680 C CD  . ARG A 1 220 ? 29.97898  6.93088   -38.90992 1.000 18.52425 ? 222 ARG A CD  1 
ATOM   1681 N NE  . ARG A 1 220 ? 30.22959  6.02608   -40.03000 1.000 17.37796 ? 222 ARG A NE  1 
ATOM   1682 C CZ  . ARG A 1 220 ? 30.35863  6.42372   -41.29313 1.000 21.76958 ? 222 ARG A CZ  1 
ATOM   1683 N NH1 . ARG A 1 220 ? 30.25617  7.71227   -41.60646 1.000 20.74037 ? 222 ARG A NH1 1 
ATOM   1684 N NH2 . ARG A 1 220 ? 30.58643  5.53507   -42.24748 1.000 23.12570 ? 222 ARG A NH2 1 
ATOM   1685 N N   . PHE A 1 221 ? 24.89023  8.38872   -39.04665 1.000 12.86656 ? 223 PHE A N   1 
ATOM   1686 C CA  . PHE A 1 221 ? 24.26677  8.69983   -40.32086 1.000 10.68640 ? 223 PHE A CA  1 
ATOM   1687 C C   . PHE A 1 221 ? 23.16408  9.74056   -40.18189 1.000 10.85682 ? 223 PHE A C   1 
ATOM   1688 O O   . PHE A 1 221 ? 22.70253  10.07401  -39.09342 1.000 9.25453  ? 223 PHE A O   1 
ATOM   1689 C CB  . PHE A 1 221 ? 23.72231  7.43042   -40.96636 1.000 10.37373 ? 223 PHE A CB  1 
ATOM   1690 C CG  . PHE A 1 221 ? 24.79316  6.47620   -41.38648 1.000 15.58371 ? 223 PHE A CG  1 
ATOM   1691 C CD1 . PHE A 1 221 ? 25.90727  6.93362   -42.07917 1.000 19.42813 ? 223 PHE A CD1 1 
ATOM   1692 C CD2 . PHE A 1 221 ? 24.70987  5.13741   -41.06544 1.000 15.12381 ? 223 PHE A CD2 1 
ATOM   1693 C CE1 . PHE A 1 221 ? 26.91408  6.06831   -42.46290 1.000 15.08781 ? 223 PHE A CE1 1 
ATOM   1694 C CE2 . PHE A 1 221 ? 25.71331  4.26684   -41.44357 1.000 19.40179 ? 223 PHE A CE2 1 
ATOM   1695 C CZ  . PHE A 1 221 ? 26.81244  4.73657   -42.15375 1.000 18.33231 ? 223 PHE A CZ  1 
ATOM   1696 N N   . THR A 1 222 ? 22.76869  10.27941  -41.32297 1.000 12.12082 ? 224 THR A N   1 
ATOM   1697 C CA  . THR A 1 222 ? 21.57105  11.08498  -41.42705 1.000 13.68346 ? 224 THR A CA  1 
ATOM   1698 C C   . THR A 1 222 ? 20.76230  10.55753  -42.60603 1.000 11.98706 ? 224 THR A C   1 
ATOM   1699 O O   . THR A 1 222 ? 21.13198  9.55551   -43.22566 1.000 9.19757  ? 224 THR A O   1 
ATOM   1700 C CB  . THR A 1 222 ? 21.91489  12.57443  -41.55667 1.000 17.39311 ? 224 THR A CB  1 
ATOM   1701 O OG1 . THR A 1 222 ? 20.77520  13.35427  -41.15814 1.000 13.78824 ? 224 THR A OG1 1 
ATOM   1702 C CG2 . THR A 1 222 ? 22.35590  12.93596  -42.99068 1.000 12.03725 ? 224 THR A CG2 1 
ATOM   1703 N N   . THR A 1 223 ? 19.63893  11.21458  -42.90152 1.000 6.23978  ? 225 THR A N   1 
ATOM   1704 C CA  . THR A 1 223 ? 18.76552  10.77626  -43.98209 1.000 7.60724  ? 225 THR A CA  1 
ATOM   1705 C C   . THR A 1 223 ? 17.88066  11.93968  -44.41174 1.000 7.13424  ? 225 THR A C   1 
ATOM   1706 O O   . THR A 1 223 ? 17.55827  12.81631  -43.60608 1.000 10.09437 ? 225 THR A O   1 
ATOM   1707 C CB  . THR A 1 223 ? 17.89083  9.58477   -43.56368 1.000 9.10867  ? 225 THR A CB  1 
ATOM   1708 O OG1 . THR A 1 223 ? 17.06097  9.18603   -44.66527 1.000 5.49660  ? 225 THR A OG1 1 
ATOM   1709 C CG2 . THR A 1 223 ? 16.98627  9.95900   -42.37026 1.000 7.39264  ? 225 THR A CG2 1 
ATOM   1710 N N   . THR A 1 224 ? 17.50962  11.95315  -45.69101 1.000 5.76671  ? 226 THR A N   1 
ATOM   1711 C CA  . THR A 1 224 ? 16.46973  12.87673  -46.11904 1.000 6.82003  ? 226 THR A CA  1 
ATOM   1712 C C   . THR A 1 224 ? 15.09732  12.37578  -45.64500 1.000 7.47958  ? 226 THR A C   1 
ATOM   1713 O O   . THR A 1 224 ? 14.90546  11.19697  -45.32707 1.000 6.72199  ? 226 THR A O   1 
ATOM   1714 C CB  . THR A 1 224 ? 16.46479  13.05372  -47.64709 1.000 7.11730  ? 226 THR A CB  1 
ATOM   1715 O OG1 . THR A 1 224 ? 15.99703  11.85213  -48.27089 1.000 5.90760  ? 226 THR A OG1 1 
ATOM   1716 C CG2 . THR A 1 224 ? 17.86658  13.39768  -48.17959 1.000 5.39062  ? 226 THR A CG2 1 
ATOM   1717 N N   . LEU A 1 225 ? 14.13139  13.29159  -45.59773 1.000 7.16400  ? 227 LEU A N   1 
ATOM   1718 C CA  . LEU A 1 225 ? 12.79539  12.90459  -45.16482 1.000 8.56341  ? 227 LEU A CA  1 
ATOM   1719 C C   . LEU A 1 225 ? 12.18637  11.88484  -46.11442 1.000 6.44791  ? 227 LEU A C   1 
ATOM   1720 O O   . LEU A 1 225 ? 11.47740  10.96680  -45.68254 1.000 10.87361 ? 227 LEU A O   1 
ATOM   1721 C CB  . LEU A 1 225 ? 11.90266  14.13841  -45.04081 1.000 7.15176  ? 227 LEU A CB  1 
ATOM   1722 C CG  . LEU A 1 225 ? 10.43509  13.93456  -44.64963 1.000 11.09605 ? 227 LEU A CG  1 
ATOM   1723 C CD1 . LEU A 1 225 ? 10.30172  13.23707  -43.29382 1.000 8.83078  ? 227 LEU A CD1 1 
ATOM   1724 C CD2 . LEU A 1 225 ? 9.70278   15.27339  -44.64298 1.000 8.35727  ? 227 LEU A CD2 1 
ATOM   1725 N N   . ASN A 1 226 ? 12.46213  12.01205  -47.40872 1.000 6.81045  ? 228 ASN A N   1 
ATOM   1726 C CA  . ASN A 1 226 ? 11.84066  11.10979  -48.37186 1.000 5.88609  ? 228 ASN A CA  1 
ATOM   1727 C C   . ASN A 1 226 ? 12.42835  9.70699   -48.29504 1.000 6.89075  ? 228 ASN A C   1 
ATOM   1728 O O   . ASN A 1 226 ? 11.68755  8.71341   -48.31269 1.000 5.48516  ? 228 ASN A O   1 
ATOM   1729 C CB  . ASN A 1 226 ? 11.98554  11.65214  -49.78285 1.000 8.76272  ? 228 ASN A CB  1 
ATOM   1730 C CG  . ASN A 1 226 ? 11.05771  10.95330  -50.74285 1.000 13.41942 ? 228 ASN A CG  1 
ATOM   1731 O OD1 . ASN A 1 226 ? 11.48120  10.48443  -51.78775 1.000 13.66736 ? 228 ASN A OD1 1 
ATOM   1732 N ND2 . ASN A 1 226 ? 9.77180   10.83788  -50.36251 1.000 14.16889 ? 228 ASN A ND2 1 
ATOM   1733 N N   . ASP A 1 227 ? 13.76647  9.60565   -48.23128 1.000 6.43533  ? 229 ASP A N   1 
ATOM   1734 C CA  . ASP A 1 227 ? 14.40923  8.30873   -48.02157 1.000 5.52961  ? 229 ASP A CA  1 
ATOM   1735 C C   . ASP A 1 227 ? 13.90847  7.63523   -46.74613 1.000 5.42284  ? 229 ASP A C   1 
ATOM   1736 O O   . ASP A 1 227 ? 13.66246  6.42382   -46.73193 1.000 4.35771  ? 229 ASP A O   1 
ATOM   1737 C CB  . ASP A 1 227 ? 15.93776  8.47183   -47.96154 1.000 5.97572  ? 229 ASP A CB  1 
ATOM   1738 C CG  . ASP A 1 227 ? 16.54594  8.72955   -49.32559 1.000 8.70103  ? 229 ASP A CG  1 
ATOM   1739 O OD1 . ASP A 1 227 ? 15.81048  8.58435   -50.32125 1.000 6.15333  ? 229 ASP A OD1 1 
ATOM   1740 O OD2 . ASP A 1 227 ? 17.75095  9.07764   -49.39510 1.000 13.58737 ? 229 ASP A OD2 1 
ATOM   1741 N N   . PHE A 1 228 ? 13.79626  8.38756   -45.64907 1.000 4.54804  ? 230 PHE A N   1 
ATOM   1742 C CA  . PHE A 1 228 ? 13.28266  7.77469   -44.42721 1.000 5.40606  ? 230 PHE A CA  1 
ATOM   1743 C C   . PHE A 1 228 ? 11.91265  7.14135   -44.67213 1.000 7.13406  ? 230 PHE A C   1 
ATOM   1744 O O   . PHE A 1 228 ? 11.67477  5.98328   -44.30144 1.000 3.04785  ? 230 PHE A O   1 
ATOM   1745 C CB  . PHE A 1 228 ? 13.18970  8.79035   -43.29127 1.000 4.00159  ? 230 PHE A CB  1 
ATOM   1746 C CG  . PHE A 1 228 ? 12.47895  8.24176   -42.09087 1.000 5.44974  ? 230 PHE A CG  1 
ATOM   1747 C CD1 . PHE A 1 228 ? 13.15662  7.42017   -41.19069 1.000 4.24432  ? 230 PHE A CD1 1 
ATOM   1748 C CD2 . PHE A 1 228 ? 11.11607  8.46551   -41.90579 1.000 5.67336  ? 230 PHE A CD2 1 
ATOM   1749 C CE1 . PHE A 1 228 ? 12.49653  6.88345   -40.08446 1.000 6.87335  ? 230 PHE A CE1 1 
ATOM   1750 C CE2 . PHE A 1 228 ? 10.44872  7.92223   -40.81788 1.000 4.55146  ? 230 PHE A CE2 1 
ATOM   1751 C CZ  . PHE A 1 228 ? 11.13342  7.14347   -39.90078 1.000 5.95252  ? 230 PHE A CZ  1 
ATOM   1752 N N   . ASN A 1 229 ? 11.01378  7.87865   -45.33814 1.000 5.73350  ? 231 ASN A N   1 
ATOM   1753 C CA  . ASN A 1 229 ? 9.65857   7.38179   -45.56533 1.000 5.28916  ? 231 ASN A CA  1 
ATOM   1754 C C   . ASN A 1 229 ? 9.63739   6.16883   -46.48477 1.000 7.51386  ? 231 ASN A C   1 
ATOM   1755 O O   . ASN A 1 229 ? 8.86068   5.23398   -46.25240 1.000 7.75121  ? 231 ASN A O   1 
ATOM   1756 C CB  . ASN A 1 229 ? 8.78193   8.50249   -46.11313 1.000 8.59692  ? 231 ASN A CB  1 
ATOM   1757 C CG  . ASN A 1 229 ? 8.29769   9.41678   -45.01713 1.000 6.77916  ? 231 ASN A CG  1 
ATOM   1758 O OD1 . ASN A 1 229 ? 8.17094   8.99141   -43.87505 1.000 6.62507  ? 231 ASN A OD1 1 
ATOM   1759 N ND2 . ASN A 1 229 ? 8.05737   10.67268  -45.34014 1.000 10.80026 ? 231 ASN A ND2 1 
ATOM   1760 N N   . LEU A 1 230 ? 10.48740  6.14740   -47.52123 1.000 4.78109  ? 232 LEU A N   1 
ATOM   1761 C CA  . LEU A 1 230 ? 10.50706  4.99490   -48.41879 1.000 5.37589  ? 232 LEU A CA  1 
ATOM   1762 C C   . LEU A 1 230 ? 10.89457  3.72306   -47.66714 1.000 5.54146  ? 232 LEU A C   1 
ATOM   1763 O O   . LEU A 1 230 ? 10.33405  2.65189   -47.92277 1.000 8.72067  ? 232 LEU A O   1 
ATOM   1764 C CB  . LEU A 1 230 ? 11.45691  5.24621   -49.60907 1.000 6.08796  ? 232 LEU A CB  1 
ATOM   1765 C CG  . LEU A 1 230 ? 10.97907  6.22239   -50.70088 1.000 4.88253  ? 232 LEU A CG  1 
ATOM   1766 C CD1 . LEU A 1 230 ? 12.12804  6.82040   -51.51566 1.000 4.27158  ? 232 LEU A CD1 1 
ATOM   1767 C CD2 . LEU A 1 230 ? 9.91776   5.59573   -51.64516 1.000 5.40992  ? 232 LEU A CD2 1 
ATOM   1768 N N   . VAL A 1 231 ? 11.84473  3.81699   -46.72867 1.000 5.60530  ? 233 VAL A N   1 
ATOM   1769 C CA  . VAL A 1 231 ? 12.20719  2.64623   -45.93287 1.000 5.37721  ? 233 VAL A CA  1 
ATOM   1770 C C   . VAL A 1 231 ? 11.10542  2.30857   -44.93105 1.000 4.53418  ? 233 VAL A C   1 
ATOM   1771 O O   . VAL A 1 231 ? 10.65174  1.16319   -44.83858 1.000 3.19106  ? 233 VAL A O   1 
ATOM   1772 C CB  . VAL A 1 231 ? 13.54161  2.86926   -45.20555 1.000 5.80863  ? 233 VAL A CB  1 
ATOM   1773 C CG1 . VAL A 1 231 ? 13.77146  1.72933   -44.20479 1.000 3.24434  ? 233 VAL A CG1 1 
ATOM   1774 C CG2 . VAL A 1 231 ? 14.67375  2.95598   -46.19660 1.000 8.15659  ? 233 VAL A CG2 1 
ATOM   1775 N N   . ALA A 1 232 ? 10.69372  3.29249   -44.13794 1.000 5.35342  ? 234 ALA A N   1 
ATOM   1776 C CA  . ALA A 1 232 ? 9.83869   3.00728   -42.99564 1.000 5.14807  ? 234 ALA A CA  1 
ATOM   1777 C C   . ALA A 1 232 ? 8.49840   2.44158   -43.43781 1.000 9.13333  ? 234 ALA A C   1 
ATOM   1778 O O   . ALA A 1 232 ? 7.91851   1.59782   -42.74216 1.000 7.70721  ? 234 ALA A O   1 
ATOM   1779 C CB  . ALA A 1 232 ? 9.64599   4.27398   -42.16355 1.000 5.98518  ? 234 ALA A CB  1 
ATOM   1780 N N   . MET A 1 233 ? 8.00590   2.86470   -44.60413 1.000 9.43990  ? 235 MET A N   1 
ATOM   1781 C CA  . MET A 1 233 ? 6.74956   2.32384   -45.10210 1.000 8.84767  ? 235 MET A CA  1 
ATOM   1782 C C   . MET A 1 233 ? 6.87390   0.84666   -45.45351 1.000 9.21615  ? 235 MET A C   1 
ATOM   1783 O O   . MET A 1 233 ? 5.88643   0.11683   -45.37390 1.000 8.57128  ? 235 MET A O   1 
ATOM   1784 C CB  . MET A 1 233 ? 6.26311   3.14844   -46.29432 1.000 14.58634 ? 235 MET A CB  1 
ATOM   1785 C CG  . MET A 1 233 ? 5.76650   4.54665   -45.86260 1.000 14.97913 ? 235 MET A CG  1 
ATOM   1786 S SD  . MET A 1 233 ? 5.21948   5.63270   -47.20624 1.000 37.49395 ? 235 MET A SD  1 
ATOM   1787 C CE  . MET A 1 233 ? 4.05546   4.56460   -48.06208 1.000 24.03051 ? 235 MET A CE  1 
ATOM   1788 N N   . LYS A 1 234 ? 8.07422   0.37011   -45.76645 1.000 6.48359  ? 236 LYS A N   1 
ATOM   1789 C CA  . LYS A 1 234 ? 8.25234   -1.06481  -45.95356 1.000 8.78380  ? 236 LYS A CA  1 
ATOM   1790 C C   . LYS A 1 234 ? 8.05553   -1.87090  -44.67237 1.000 7.78284  ? 236 LYS A C   1 
ATOM   1791 O O   . LYS A 1 234 ? 7.92327   -3.09388  -44.76301 1.000 5.79381  ? 236 LYS A O   1 
ATOM   1792 C CB  . LYS A 1 234 ? 9.63766   -1.34812  -46.53670 1.000 6.24514  ? 236 LYS A CB  1 
ATOM   1793 C CG  . LYS A 1 234 ? 9.68430   -1.08251  -48.01253 1.000 8.58589  ? 236 LYS A CG  1 
ATOM   1794 C CD  . LYS A 1 234 ? 11.08032  -0.78862  -48.51585 1.000 11.30470 ? 236 LYS A CD  1 
ATOM   1795 C CE  . LYS A 1 234 ? 10.96441  -0.17357  -49.89872 1.000 14.47552 ? 236 LYS A CE  1 
ATOM   1796 N NZ  . LYS A 1 234 ? 12.13439  0.66936   -50.20569 1.000 18.40672 ? 236 LYS A NZ  1 
ATOM   1797 N N   . TYR A 1 235 ? 8.05335   -1.23432  -43.49553 1.000 3.82331  ? 237 TYR A N   1 
ATOM   1798 C CA  . TYR A 1 235 ? 7.75287   -1.90507  -42.23519 1.000 6.01465  ? 237 TYR A CA  1 
ATOM   1799 C C   . TYR A 1 235 ? 6.36550   -1.53322  -41.69932 1.000 9.14416  ? 237 TYR A C   1 
ATOM   1800 O O   . TYR A 1 235 ? 6.07533   -1.78400  -40.52284 1.000 4.16325  ? 237 TYR A O   1 
ATOM   1801 C CB  . TYR A 1 235 ? 8.79853   -1.58462  -41.16882 1.000 5.29946  ? 237 TYR A CB  1 
ATOM   1802 C CG  . TYR A 1 235 ? 10.23417  -1.92077  -41.51665 1.000 5.59666  ? 237 TYR A CG  1 
ATOM   1803 C CD1 . TYR A 1 235 ? 11.00349  -1.08281  -42.33471 1.000 8.41680  ? 237 TYR A CD1 1 
ATOM   1804 C CD2 . TYR A 1 235 ? 10.83231  -3.06655  -41.00875 1.000 8.21214  ? 237 TYR A CD2 1 
ATOM   1805 C CE1 . TYR A 1 235 ? 12.33551  -1.39962  -42.64635 1.000 7.33716  ? 237 TYR A CE1 1 
ATOM   1806 C CE2 . TYR A 1 235 ? 12.14827  -3.39351  -41.31326 1.000 7.15060  ? 237 TYR A CE2 1 
ATOM   1807 C CZ  . TYR A 1 235 ? 12.90135  -2.56343  -42.12334 1.000 10.83278 ? 237 TYR A CZ  1 
ATOM   1808 O OH  . TYR A 1 235 ? 14.22597  -2.90779  -42.37894 1.000 8.11072  ? 237 TYR A OH  1 
ATOM   1809 N N   . ASN A 1 236 ? 5.52456   -0.90873  -42.53144 1.000 8.49038  ? 238 ASN A N   1 
ATOM   1810 C CA  . ASN A 1 236 ? 4.15543   -0.53503  -42.16865 1.000 10.69989 ? 238 ASN A CA  1 
ATOM   1811 C C   . ASN A 1 236 ? 4.15056   0.57598   -41.11813 1.000 12.78682 ? 238 ASN A C   1 
ATOM   1812 O O   . ASN A 1 236 ? 3.31280   0.60019   -40.20962 1.000 10.95668 ? 238 ASN A O   1 
ATOM   1813 C CB  . ASN A 1 236 ? 3.36140   -1.76313  -41.70530 1.000 10.37916 ? 238 ASN A CB  1 
ATOM   1814 C CG  . ASN A 1 236 ? 1.88456   -1.49687  -41.58161 1.000 22.62920 ? 238 ASN A CG  1 
ATOM   1815 O OD1 . ASN A 1 236 ? 1.20478   -1.18042  -42.56383 1.000 30.41383 ? 238 ASN A OD1 1 
ATOM   1816 N ND2 . ASN A 1 236 ? 1.36924   -1.63152  -40.36231 1.000 15.51991 ? 238 ASN A ND2 1 
ATOM   1817 N N   . TYR A 1 237 ? 5.12958   1.47375   -41.23135 1.000 7.99300  ? 239 TYR A N   1 
ATOM   1818 C CA  . TYR A 1 237 ? 5.20702   2.70080   -40.45007 1.000 7.32122  ? 239 TYR A CA  1 
ATOM   1819 C C   . TYR A 1 237 ? 4.44815   3.80344   -41.17857 1.000 8.56122  ? 239 TYR A C   1 
ATOM   1820 O O   . TYR A 1 237 ? 4.46471   3.86621   -42.40908 1.000 7.86632  ? 239 TYR A O   1 
ATOM   1821 C CB  . TYR A 1 237 ? 6.67817   3.11167   -40.24119 1.000 4.31188  ? 239 TYR A CB  1 
ATOM   1822 C CG  . TYR A 1 237 ? 7.26325   2.56858   -38.95470 1.000 3.95831  ? 239 TYR A CG  1 
ATOM   1823 C CD1 . TYR A 1 237 ? 7.33120   1.20209   -38.72837 1.000 2.63617  ? 239 TYR A CD1 1 
ATOM   1824 C CD2 . TYR A 1 237 ? 7.71433   3.42337   -37.95824 1.000 2.03317  ? 239 TYR A CD2 1 
ATOM   1825 C CE1 . TYR A 1 237 ? 7.83236   0.70791   -37.55560 1.000 2.42458  ? 239 TYR A CE1 1 
ATOM   1826 C CE2 . TYR A 1 237 ? 8.20701   2.93700   -36.76038 1.000 1.97346  ? 239 TYR A CE2 1 
ATOM   1827 C CZ  . TYR A 1 237 ? 8.26968   1.57664   -36.57049 1.000 2.74893  ? 239 TYR A CZ  1 
ATOM   1828 O OH  . TYR A 1 237 ? 8.75494   1.07363   -35.39024 1.000 6.20367  ? 239 TYR A OH  1 
ATOM   1829 N N   . GLU A 1 238 ? 3.79526   4.66959   -40.41006 1.000 10.12634 ? 240 GLU A N   1 
ATOM   1830 C CA  . GLU A 1 238 ? 3.03896   5.78720   -40.96951 1.000 6.97381  ? 240 GLU A CA  1 
ATOM   1831 C C   . GLU A 1 238 ? 3.99794   6.82949   -41.53429 1.000 10.23817 ? 240 GLU A C   1 
ATOM   1832 O O   . GLU A 1 238 ? 4.99531   7.16143   -40.87970 1.000 9.81918  ? 240 GLU A O   1 
ATOM   1833 C CB  . GLU A 1 238 ? 2.16258   6.40938   -39.87590 1.000 7.41273  ? 240 GLU A CB  1 
ATOM   1834 C CG  . GLU A 1 238 ? 1.44369   7.70035   -40.26293 1.000 9.05964  ? 240 GLU A CG  1 
ATOM   1835 C CD  . GLU A 1 238 ? 0.18726   7.44931   -41.12236 1.000 10.93977 ? 240 GLU A CD  1 
ATOM   1836 O OE1 . GLU A 1 238 ? -0.22271  8.37924   -41.85933 1.000 9.23541  ? 240 GLU A OE1 1 
ATOM   1837 O OE2 . GLU A 1 238 ? -0.36870  6.32452   -41.07321 1.000 7.24961  ? 240 GLU A OE2 1 
ATOM   1838 N N   . PRO A 1 239 ? 3.74388   7.36843   -42.72973 1.000 12.05825 ? 241 PRO A N   1 
ATOM   1839 C CA  . PRO A 1 239 ? 4.65730   8.37857   -43.28264 1.000 12.51401 ? 241 PRO A CA  1 
ATOM   1840 C C   . PRO A 1 239 ? 4.80273   9.58654   -42.36366 1.000 11.22699 ? 241 PRO A C   1 
ATOM   1841 O O   . PRO A 1 239 ? 3.83444   10.05362  -41.75294 1.000 6.90823  ? 241 PRO A O   1 
ATOM   1842 C CB  . PRO A 1 239 ? 4.01711   8.75387   -44.62972 1.000 11.02325 ? 241 PRO A CB  1 
ATOM   1843 C CG  . PRO A 1 239 ? 2.75507   7.93125   -44.74636 1.000 11.47655 ? 241 PRO A CG  1 
ATOM   1844 C CD  . PRO A 1 239 ? 2.83460   6.82339   -43.75327 1.000 8.68976  ? 241 PRO A CD  1 
ATOM   1845 N N   . LEU A 1 240 ? 6.04685   10.06845  -42.25322 1.000 9.86788  ? 242 LEU A N   1 
ATOM   1846 C CA  . LEU A 1 240 ? 6.38930   11.24505  -41.45377 1.000 9.72438  ? 242 LEU A CA  1 
ATOM   1847 C C   . LEU A 1 240 ? 6.22051   12.50377  -42.30686 1.000 9.56903  ? 242 LEU A C   1 
ATOM   1848 O O   . LEU A 1 240 ? 6.68409   12.54971  -43.44833 1.000 12.15259 ? 242 LEU A O   1 
ATOM   1849 C CB  . LEU A 1 240 ? 7.83496   11.13693  -40.92920 1.000 8.45075  ? 242 LEU A CB  1 
ATOM   1850 C CG  . LEU A 1 240 ? 8.27739   11.99653  -39.73537 1.000 10.12575 ? 242 LEU A CG  1 
ATOM   1851 C CD1 . LEU A 1 240 ? 7.56271   11.56697  -38.42772 1.000 8.02003  ? 242 LEU A CD1 1 
ATOM   1852 C CD2 . LEU A 1 240 ? 9.79447   11.99579  -39.53502 1.000 8.37186  ? 242 LEU A CD2 1 
ATOM   1853 N N   . THR A 1 241 ? 5.56608   13.52122  -41.75320 1.000 9.54946  ? 243 THR A N   1 
ATOM   1854 C CA  . THR A 1 241 ? 5.28265   14.75578  -42.46862 1.000 9.66244  ? 243 THR A CA  1 
ATOM   1855 C C   . THR A 1 241 ? 6.15249   15.88304  -41.94035 1.000 11.72148 ? 243 THR A C   1 
ATOM   1856 O O   . THR A 1 241 ? 6.80890   15.76763  -40.89852 1.000 10.10946 ? 243 THR A O   1 
ATOM   1857 C CB  . THR A 1 241 ? 3.80586   15.15542  -42.32993 1.000 10.43434 ? 243 THR A CB  1 
ATOM   1858 O OG1 . THR A 1 241 ? 3.53444   15.49156  -40.96084 1.000 10.38447 ? 243 THR A OG1 1 
ATOM   1859 C CG2 . THR A 1 241 ? 2.89525   14.03188  -42.78432 1.000 6.38824  ? 243 THR A CG2 1 
ATOM   1860 N N   . GLN A 1 242 ? 6.11379   17.00793  -42.65774 1.000 8.24933  ? 244 GLN A N   1 
ATOM   1861 C CA  . GLN A 1 242 ? 6.80681   18.18694  -42.16389 1.000 13.11522 ? 244 GLN A CA  1 
ATOM   1862 C C   . GLN A 1 242 ? 6.22605   18.65815  -40.83728 1.000 13.14555 ? 244 GLN A C   1 
ATOM   1863 O O   . GLN A 1 242 ? 6.96859   19.13904  -39.97458 1.000 15.23380 ? 244 GLN A O   1 
ATOM   1864 C CB  . GLN A 1 242 ? 6.77774   19.30547  -43.20201 1.000 12.11902 ? 244 GLN A CB  1 
ATOM   1865 C CG  . GLN A 1 242 ? 7.77937   20.41696  -42.88263 1.000 15.71372 ? 244 GLN A CG  1 
ATOM   1866 C CD  . GLN A 1 242 ? 9.17999   19.87877  -42.53562 1.000 17.94828 ? 244 GLN A CD  1 
ATOM   1867 O OE1 . GLN A 1 242 ? 9.69799   18.96579  -43.18649 1.000 22.10480 ? 244 GLN A OE1 1 
ATOM   1868 N NE2 . GLN A 1 242 ? 9.78555   20.44567  -41.50328 1.000 13.24919 ? 244 GLN A NE2 1 
ATOM   1869 N N   . ASP A 1 243 ? 4.91355   18.50583  -40.64119 1.000 11.32791 ? 245 ASP A N   1 
ATOM   1870 C CA  . ASP A 1 243 ? 4.32130   18.82499  -39.34544 1.000 14.67465 ? 245 ASP A CA  1 
ATOM   1871 C C   . ASP A 1 243 ? 4.96034   18.00429  -38.22620 1.000 11.50293 ? 245 ASP A C   1 
ATOM   1872 O O   . ASP A 1 243 ? 5.26530   18.52991  -37.14531 1.000 13.70290 ? 245 ASP A O   1 
ATOM   1873 C CB  . ASP A 1 243 ? 2.80871   18.57884  -39.39068 1.000 12.72666 ? 245 ASP A CB  1 
ATOM   1874 C CG  . ASP A 1 243 ? 2.06385   19.61295  -40.23496 1.000 18.09115 ? 245 ASP A CG  1 
ATOM   1875 O OD1 . ASP A 1 243 ? 2.45764   19.84643  -41.40244 1.000 25.43955 ? 245 ASP A OD1 1 
ATOM   1876 O OD2 . ASP A 1 243 ? 1.05973   20.16925  -39.74123 1.000 24.42411 ? 245 ASP A OD2 1 
ATOM   1877 N N   . HIS A 1 244 ? 5.14921   16.70601  -38.45873 1.000 12.06382 ? 246 HIS A N   1 
ATOM   1878 C CA  . HIS A 1 244 ? 5.76471   15.85870  -37.44179 1.000 15.28920 ? 246 HIS A CA  1 
ATOM   1879 C C   . HIS A 1 244 ? 7.20310   16.27859  -37.15407 1.000 14.05665 ? 246 HIS A C   1 
ATOM   1880 O O   . HIS A 1 244 ? 7.66557   16.17066  -36.00942 1.000 10.52991 ? 246 HIS A O   1 
ATOM   1881 C CB  . HIS A 1 244 ? 5.71988   14.39685  -37.88219 1.000 9.04619  ? 246 HIS A CB  1 
ATOM   1882 C CG  . HIS A 1 244 ? 4.33846   13.85405  -38.05194 1.000 10.00433 ? 246 HIS A CG  1 
ATOM   1883 N ND1 . HIS A 1 244 ? 4.04441   12.83985  -38.93948 1.000 9.04738  ? 246 HIS A ND1 1 
ATOM   1884 C CD2 . HIS A 1 244 ? 3.17155   14.17414  -37.43922 1.000 8.96967  ? 246 HIS A CD2 1 
ATOM   1885 C CE1 . HIS A 1 244 ? 2.75070   12.57039  -38.87524 1.000 12.83179 ? 246 HIS A CE1 1 
ATOM   1886 N NE2 . HIS A 1 244 ? 2.20286   13.35737  -37.96417 1.000 8.80166  ? 246 HIS A NE2 1 
ATOM   1887 N N   . VAL A 1 245 ? 7.91881   16.76058  -38.17281 1.000 10.68221 ? 247 VAL A N   1 
ATOM   1888 C CA  . VAL A 1 245 ? 9.28529   17.22373  -37.96550 1.000 14.61259 ? 247 VAL A CA  1 
ATOM   1889 C C   . VAL A 1 245 ? 9.29480   18.49254  -37.11943 1.000 14.93079 ? 247 VAL A C   1 
ATOM   1890 O O   . VAL A 1 245 ? 10.08773  18.61804  -36.18014 1.000 18.73645 ? 247 VAL A O   1 
ATOM   1891 C CB  . VAL A 1 245 ? 9.99715   17.43067  -39.31617 1.000 13.83634 ? 247 VAL A CB  1 
ATOM   1892 C CG1 . VAL A 1 245 ? 11.43091  17.88554  -39.08651 1.000 12.78272 ? 247 VAL A CG1 1 
ATOM   1893 C CG2 . VAL A 1 245 ? 9.97492   16.13968  -40.13851 1.000 8.33893  ? 247 VAL A CG2 1 
ATOM   1894 N N   . ASP A 1 246 ? 8.42154   19.45479  -37.44296 1.000 13.52814 ? 248 ASP A N   1 
ATOM   1895 C CA  . ASP A 1 246 ? 8.28702   20.64014  -36.59974 1.000 14.55036 ? 248 ASP A CA  1 
ATOM   1896 C C   . ASP A 1 246 ? 7.93130   20.25243  -35.17042 1.000 16.51156 ? 248 ASP A C   1 
ATOM   1897 O O   . ASP A 1 246 ? 8.45304   20.83272  -34.21212 1.000 18.68033 ? 248 ASP A O   1 
ATOM   1898 C CB  . ASP A 1 246 ? 7.21622   21.58825  -37.15181 1.000 19.66724 ? 248 ASP A CB  1 
ATOM   1899 C CG  . ASP A 1 246 ? 7.51262   22.07948  -38.56363 1.000 23.13184 ? 248 ASP A CG  1 
ATOM   1900 O OD1 . ASP A 1 246 ? 8.69269   22.09504  -38.96992 1.000 19.79166 ? 248 ASP A OD1 1 
ATOM   1901 O OD2 . ASP A 1 246 ? 6.54600   22.46088  -39.26760 1.000 24.90934 ? 248 ASP A OD2 1 
ATOM   1902 N N   . ILE A 1 247 ? 7.04630   19.26362  -35.01108 1.000 14.50706 ? 249 ILE A N   1 
ATOM   1903 C CA  . ILE A 1 247 ? 6.54318   18.90509  -33.68718 1.000 14.31603 ? 249 ILE A CA  1 
ATOM   1904 C C   . ILE A 1 247 ? 7.67253   18.36292  -32.81093 1.000 12.40330 ? 249 ILE A C   1 
ATOM   1905 O O   . ILE A 1 247 ? 7.72691   18.62563  -31.60457 1.000 11.56263 ? 249 ILE A O   1 
ATOM   1906 C CB  . ILE A 1 247 ? 5.36921   17.90990  -33.83325 1.000 13.48570 ? 249 ILE A CB  1 
ATOM   1907 C CG1 . ILE A 1 247 ? 4.03836   18.66741  -34.01463 1.000 19.98827 ? 249 ILE A CG1 1 
ATOM   1908 C CG2 . ILE A 1 247 ? 5.26803   16.99485  -32.64668 1.000 12.46953 ? 249 ILE A CG2 1 
ATOM   1909 C CD1 . ILE A 1 247 ? 2.98703   17.94566  -34.87312 1.000 16.92175 ? 249 ILE A CD1 1 
ATOM   1910 N N   . LEU A 1 248 ? 8.60356   17.62297  -33.40499 1.000 14.09887 ? 250 LEU A N   1 
ATOM   1911 C CA  . LEU A 1 248 ? 9.71646   17.06616  -32.64965 1.000 13.26192 ? 250 LEU A CA  1 
ATOM   1912 C C   . LEU A 1 248 ? 10.82768  18.07792  -32.39212 1.000 12.51311 ? 250 LEU A C   1 
ATOM   1913 O O   . LEU A 1 248 ? 11.79435  17.74180  -31.70860 1.000 10.73465 ? 250 LEU A O   1 
ATOM   1914 C CB  . LEU A 1 248 ? 10.28036  15.84871  -33.37983 1.000 9.34236  ? 250 LEU A CB  1 
ATOM   1915 C CG  . LEU A 1 248 ? 9.35114   14.65219  -33.57470 1.000 8.78076  ? 250 LEU A CG  1 
ATOM   1916 C CD1 . LEU A 1 248 ? 9.88624   13.74327  -34.68298 1.000 9.17856  ? 250 LEU A CD1 1 
ATOM   1917 C CD2 . LEU A 1 248 ? 9.16847   13.86890  -32.28812 1.000 6.75407  ? 250 LEU A CD2 1 
ATOM   1918 N N   . GLY A 1 249 ? 10.70593  19.30307  -32.89448 1.000 14.73021 ? 251 GLY A N   1 
ATOM   1919 C CA  . GLY A 1 249 ? 11.74193  20.30257  -32.76052 1.000 11.83320 ? 251 GLY A CA  1 
ATOM   1920 C C   . GLY A 1 249 ? 12.22123  20.57431  -31.34348 1.000 19.30790 ? 251 GLY A C   1 
ATOM   1921 O O   . GLY A 1 249 ? 13.42958  20.65629  -31.08516 1.000 21.79133 ? 251 GLY A O   1 
ATOM   1922 N N   . PRO A 1 250 ? 11.29532  20.76662  -30.39867 1.000 18.46446 ? 252 PRO A N   1 
ATOM   1923 C CA  . PRO A 1 250 ? 11.74061  21.01022  -29.01410 1.000 17.11446 ? 252 PRO A CA  1 
ATOM   1924 C C   . PRO A 1 250 ? 12.53153  19.86234  -28.40660 1.000 15.82893 ? 252 PRO A C   1 
ATOM   1925 O O   . PRO A 1 250 ? 13.53243  20.11620  -27.72435 1.000 15.79063 ? 252 PRO A O   1 
ATOM   1926 C CB  . PRO A 1 250 ? 10.42527  21.26653  -28.27429 1.000 12.48944 ? 252 PRO A CB  1 
ATOM   1927 C CG  . PRO A 1 250 ? 9.53889   21.85695  -29.32973 1.000 11.98841 ? 252 PRO A CG  1 
ATOM   1928 C CD  . PRO A 1 250 ? 9.87514   21.11585  -30.58196 1.000 16.12425 ? 252 PRO A CD  1 
ATOM   1929 N N   . LEU A 1 251 ? 12.11439  18.60788  -28.61529 1.000 10.86269 ? 253 LEU A N   1 
ATOM   1930 C CA  . LEU A 1 251 ? 12.90747  17.48363  -28.11675 1.000 14.66042 ? 253 LEU A CA  1 
ATOM   1931 C C   . LEU A 1 251 ? 14.26727  17.41522  -28.80935 1.000 15.15356 ? 253 LEU A C   1 
ATOM   1932 O O   . LEU A 1 251 ? 15.28958  17.13134  -28.16881 1.000 13.93955 ? 253 LEU A O   1 
ATOM   1933 C CB  . LEU A 1 251 ? 12.15500  16.17544  -28.32631 1.000 7.38148  ? 253 LEU A CB  1 
ATOM   1934 C CG  . LEU A 1 251 ? 10.88020  15.99045  -27.52953 1.000 9.53225  ? 253 LEU A CG  1 
ATOM   1935 C CD1 . LEU A 1 251 ? 10.20526  14.74445  -28.03879 1.000 6.37307  ? 253 LEU A CD1 1 
ATOM   1936 C CD2 . LEU A 1 251 ? 11.20162  15.88557  -26.03012 1.000 10.91977 ? 253 LEU A CD2 1 
ATOM   1937 N N   . SER A 1 252 ? 14.27843  17.62502  -30.12958 1.000 10.27657 ? 254 SER A N   1 
ATOM   1938 C CA  . SER A 1 252 ? 15.51808  17.72890  -30.88399 1.000 16.18888 ? 254 SER A CA  1 
ATOM   1939 C C   . SER A 1 252 ? 16.44519  18.75354  -30.25220 1.000 18.15594 ? 254 SER A C   1 
ATOM   1940 O O   . SER A 1 252 ? 17.61355  18.46353  -29.95672 1.000 17.71339 ? 254 SER A O   1 
ATOM   1941 C CB  . SER A 1 252 ? 15.20939  18.11692  -32.33232 1.000 12.90452 ? 254 SER A CB  1 
ATOM   1942 O OG  . SER A 1 252 ? 16.39567  18.11859  -33.11284 1.000 15.40100 ? 254 SER A OG  1 
ATOM   1943 N N   . ALA A 1 253 ? 15.92302  19.96451  -30.03143 1.000 19.96829 ? 255 ALA A N   1 
ATOM   1944 C CA  . ALA A 1 253 ? 16.72412  21.03776  -29.45660 1.000 21.47474 ? 255 ALA A CA  1 
ATOM   1945 C C   . ALA A 1 253 ? 17.18756  20.67830  -28.05025 1.000 20.61187 ? 255 ALA A C   1 
ATOM   1946 O O   . ALA A 1 253 ? 18.31670  20.99963  -27.65205 1.000 21.21290 ? 255 ALA A O   1 
ATOM   1947 C CB  . ALA A 1 253 ? 15.91796  22.33992  -29.45982 1.000 15.05988 ? 255 ALA A CB  1 
ATOM   1948 N N   . GLN A 1 254 ? 16.33890  19.98257  -27.29296 1.000 19.08661 ? 256 GLN A N   1 
ATOM   1949 C CA  . GLN A 1 254 ? 16.69227  19.63771  -25.92349 1.000 18.56309 ? 256 GLN A CA  1 
ATOM   1950 C C   . GLN A 1 254 ? 17.82463  18.61399  -25.87284 1.000 21.07758 ? 256 GLN A C   1 
ATOM   1951 O O   . GLN A 1 254 ? 18.68413  18.68083  -24.98814 1.000 20.74145 ? 256 GLN A O   1 
ATOM   1952 C CB  . GLN A 1 254 ? 15.46530  19.11660  -25.18802 1.000 19.03199 ? 256 GLN A CB  1 
ATOM   1953 C CG  . GLN A 1 254 ? 15.49171  19.42894  -23.71798 1.000 24.05415 ? 256 GLN A CG  1 
ATOM   1954 C CD  . GLN A 1 254 ? 14.80405  18.37091  -22.90739 1.000 29.45109 ? 256 GLN A CD  1 
ATOM   1955 O OE1 . GLN A 1 254 ? 13.60188  18.16059  -23.03562 1.000 35.12499 ? 256 GLN A OE1 1 
ATOM   1956 N NE2 . GLN A 1 254 ? 15.56905  17.67481  -22.07636 1.000 34.40916 ? 256 GLN A NE2 1 
ATOM   1957 N N   . THR A 1 255 ? 17.84605  17.65250  -26.80086 1.000 17.52904 ? 257 THR A N   1 
ATOM   1958 C CA  . THR A 1 255 ? 18.85404  16.60232  -26.74164 1.000 16.24146 ? 257 THR A CA  1 
ATOM   1959 C C   . THR A 1 255 ? 20.06278  16.86788  -27.63380 1.000 14.00436 ? 257 THR A C   1 
ATOM   1960 O O   . THR A 1 255 ? 21.09747  16.22369  -27.44593 1.000 14.34072 ? 257 THR A O   1 
ATOM   1961 C CB  . THR A 1 255 ? 18.25056  15.24147  -27.12212 1.000 13.51118 ? 257 THR A CB  1 
ATOM   1962 O OG1 . THR A 1 255 ? 17.78794  15.29056  -28.47389 1.000 7.29048  ? 257 THR A OG1 1 
ATOM   1963 C CG2 . THR A 1 255 ? 17.10431  14.85991  -26.18780 1.000 10.44061 ? 257 THR A CG2 1 
ATOM   1964 N N   . GLY A 1 256 ? 19.96583  17.79950  -28.57847 1.000 13.65679 ? 258 GLY A N   1 
ATOM   1965 C CA  . GLY A 1 256 ? 21.04419  18.05585  -29.50518 1.000 11.59006 ? 258 GLY A CA  1 
ATOM   1966 C C   . GLY A 1 256 ? 21.12245  17.10486  -30.67766 1.000 15.93345 ? 258 GLY A C   1 
ATOM   1967 O O   . GLY A 1 256 ? 22.14328  17.09259  -31.37672 1.000 10.35575 ? 258 GLY A O   1 
ATOM   1968 N N   . ILE A 1 257 ? 20.08760  16.30020  -30.91451 1.000 10.93413 ? 259 ILE A N   1 
ATOM   1969 C CA  . ILE A 1 257 ? 20.06753  15.33556  -32.01064 1.000 11.07812 ? 259 ILE A CA  1 
ATOM   1970 C C   . ILE A 1 257 ? 19.01656  15.77951  -33.01606 1.000 12.09892 ? 259 ILE A C   1 
ATOM   1971 O O   . ILE A 1 257 ? 17.82606  15.86652  -32.68090 1.000 8.71038  ? 259 ILE A O   1 
ATOM   1972 C CB  . ILE A 1 257 ? 19.78043  13.91489  -31.50743 1.000 13.44203 ? 259 ILE A CB  1 
ATOM   1973 C CG1 . ILE A 1 257 ? 20.93996  13.40319  -30.64014 1.000 10.78676 ? 259 ILE A CG1 1 
ATOM   1974 C CG2 . ILE A 1 257 ? 19.53543  12.99838  -32.67659 1.000 12.00834 ? 259 ILE A CG2 1 
ATOM   1975 C CD1 . ILE A 1 257 ? 20.49443  12.48172  -29.55755 1.000 9.20779  ? 259 ILE A CD1 1 
ATOM   1976 N N   . ALA A 1 258 ? 19.45421  16.06359  -34.24351 1.000 7.41422  ? 260 ALA A N   1 
ATOM   1977 C CA  . ALA A 1 258 ? 18.53648  16.52866  -35.27405 1.000 10.96602 ? 260 ALA A CA  1 
ATOM   1978 C C   . ALA A 1 258 ? 17.47985  15.47353  -35.56099 1.000 7.98221  ? 260 ALA A C   1 
ATOM   1979 O O   . ALA A 1 258 ? 17.72915  14.26817  -35.46072 1.000 7.13938  ? 260 ALA A O   1 
ATOM   1980 C CB  . ALA A 1 258 ? 19.28400  16.87348  -36.56353 1.000 10.05901 ? 260 ALA A CB  1 
ATOM   1981 N N   . VAL A 1 259 ? 16.28441  15.94560  -35.93004 1.000 9.43925  ? 261 VAL A N   1 
ATOM   1982 C CA  . VAL A 1 259 ? 15.16802  15.03537  -36.18778 1.000 7.77636  ? 261 VAL A CA  1 
ATOM   1983 C C   . VAL A 1 259 ? 15.55764  13.98761  -37.22562 1.000 6.56531  ? 261 VAL A C   1 
ATOM   1984 O O   . VAL A 1 259 ? 15.36512  12.77998  -37.02334 1.000 8.20554  ? 261 VAL A O   1 
ATOM   1985 C CB  . VAL A 1 259 ? 13.91437  15.82720  -36.61421 1.000 12.73742 ? 261 VAL A CB  1 
ATOM   1986 C CG1 . VAL A 1 259 ? 12.79181  14.88912  -36.98766 1.000 4.33755  ? 261 VAL A CG1 1 
ATOM   1987 C CG2 . VAL A 1 259 ? 13.46628  16.76620  -35.49308 1.000 9.40953  ? 261 VAL A CG2 1 
ATOM   1988 N N   . LEU A 1 260 ? 16.14530  14.42474  -38.33572 1.000 7.33397  ? 262 LEU A N   1 
ATOM   1989 C CA  . LEU A 1 260 ? 16.52485  13.47701  -39.37944 1.000 5.88081  ? 262 LEU A CA  1 
ATOM   1990 C C   . LEU A 1 260 ? 17.71870  12.60529  -38.98289 1.000 6.34924  ? 262 LEU A C   1 
ATOM   1991 O O   . LEU A 1 260 ? 17.88647  11.52089  -39.54485 1.000 6.50651  ? 262 LEU A O   1 
ATOM   1992 C CB  . LEU A 1 260 ? 16.80986  14.23144  -40.67552 1.000 8.62850  ? 262 LEU A CB  1 
ATOM   1993 C CG  . LEU A 1 260 ? 15.58166  14.81481  -41.37781 1.000 9.74300  ? 262 LEU A CG  1 
ATOM   1994 C CD1 . LEU A 1 260 ? 16.01065  15.58369  -42.62099 1.000 17.19698 ? 262 LEU A CD1 1 
ATOM   1995 C CD2 . LEU A 1 260 ? 14.60394  13.71992  -41.75048 1.000 4.12500  ? 262 LEU A CD2 1 
ATOM   1996 N N   . ASP A 1 261 ? 18.53084  13.02534  -38.00860 1.000 6.62998  ? 263 ASP A N   1 
ATOM   1997 C CA  . ASP A 1 261 ? 19.50465  12.09518  -37.44415 1.000 7.55634  ? 263 ASP A CA  1 
ATOM   1998 C C   . ASP A 1 261 ? 18.80181  11.00439  -36.64901 1.000 6.03135  ? 263 ASP A C   1 
ATOM   1999 O O   . ASP A 1 261 ? 19.10984  9.81863   -36.80192 1.000 4.02145  ? 263 ASP A O   1 
ATOM   2000 C CB  . ASP A 1 261 ? 20.52216  12.83510  -36.57114 1.000 10.98102 ? 263 ASP A CB  1 
ATOM   2001 C CG  . ASP A 1 261 ? 21.46091  13.71917  -37.38525 1.000 14.11696 ? 263 ASP A CG  1 
ATOM   2002 O OD1 . ASP A 1 261 ? 21.32895  13.74875  -38.63713 1.000 14.49582 ? 263 ASP A OD1 1 
ATOM   2003 O OD2 . ASP A 1 261 ? 22.31903  14.38937  -36.76759 1.000 17.07262 ? 263 ASP A OD2 1 
ATOM   2004 N N   . MET A 1 262 ? 17.82991  11.38271  -35.81759 1.000 7.28133  ? 264 MET A N   1 
ATOM   2005 C CA  . MET A 1 262 ? 17.04326  10.37372  -35.11605 1.000 5.42583  ? 264 MET A CA  1 
ATOM   2006 C C   . MET A 1 262 ? 16.28470  9.46954   -36.08069 1.000 4.45552  ? 264 MET A C   1 
ATOM   2007 O O   . MET A 1 262 ? 16.10181  8.27991   -35.80005 1.000 3.08536  ? 264 MET A O   1 
ATOM   2008 C CB  . MET A 1 262 ? 16.06606  11.03657  -34.14735 1.000 4.10891  ? 264 MET A CB  1 
ATOM   2009 C CG  . MET A 1 262 ? 15.50291  10.03753  -33.16391 1.000 4.64875  ? 264 MET A CG  1 
ATOM   2010 S SD  . MET A 1 262 ? 16.70339  9.62408   -31.88278 1.000 10.28996 ? 264 MET A SD  1 
ATOM   2011 C CE  . MET A 1 262 ? 16.75822  7.86427   -32.05961 1.000 8.92426  ? 264 MET A CE  1 
ATOM   2012 N N   . CYS A 1 263 ? 15.82926  10.00774  -37.21429 1.000 5.91852  ? 265 CYS A N   1 
ATOM   2013 C CA  . CYS A 1 263 ? 15.19524  9.15569   -38.21097 1.000 2.96727  ? 265 CYS A CA  1 
ATOM   2014 C C   . CYS A 1 263 ? 16.16733  8.10053   -38.71591 1.000 3.81600  ? 265 CYS A C   1 
ATOM   2015 O O   . CYS A 1 263 ? 15.78136  6.94390   -38.93243 1.000 2.70395  ? 265 CYS A O   1 
ATOM   2016 C CB  . CYS A 1 263 ? 14.65736  10.00383  -39.36561 1.000 5.74600  ? 265 CYS A CB  1 
ATOM   2017 S SG  . CYS A 1 263 ? 13.19713  10.97141  -38.91653 1.000 6.35699  ? 265 CYS A SG  1 
ATOM   2018 N N   . ALA A 1 264 ? 17.44200  8.48274   -38.88474 1.000 4.61944  ? 266 ALA A N   1 
ATOM   2019 C CA  . ALA A 1 264 ? 18.47968  7.53557   -39.29614 1.000 7.22751  ? 266 ALA A CA  1 
ATOM   2020 C C   . ALA A 1 264 ? 18.68300  6.42933   -38.26146 1.000 5.24405  ? 266 ALA A C   1 
ATOM   2021 O O   . ALA A 1 264 ? 18.87858  5.25969   -38.62057 1.000 4.08106  ? 266 ALA A O   1 
ATOM   2022 C CB  . ALA A 1 264 ? 19.79346  8.28162   -39.54774 1.000 7.97114  ? 266 ALA A CB  1 
ATOM   2023 N N   . SER A 1 265 ? 18.64580  6.77830   -36.97169 1.000 3.93316  ? 267 SER A N   1 
ATOM   2024 C CA  . SER A 1 265 ? 18.69694  5.75246   -35.93562 1.000 4.07082  ? 267 SER A CA  1 
ATOM   2025 C C   . SER A 1 265 ? 17.51254  4.78225   -36.03550 1.000 3.66623  ? 267 SER A C   1 
ATOM   2026 O O   . SER A 1 265 ? 17.69425  3.55977   -35.93695 1.000 4.38142  ? 267 SER A O   1 
ATOM   2027 C CB  . SER A 1 265 ? 18.75935  6.41489   -34.55679 1.000 8.33436  ? 267 SER A CB  1 
ATOM   2028 O OG  . SER A 1 265 ? 18.93849  5.44994   -33.52380 1.000 12.90172 ? 267 SER A OG  1 
ATOM   2029 N N   . LEU A 1 266 ? 16.29187  5.29802   -36.25684 1.000 3.44165  ? 268 LEU A N   1 
ATOM   2030 C CA  . LEU A 1 266 ? 15.13279  4.40912   -36.36701 1.000 3.41628  ? 268 LEU A CA  1 
ATOM   2031 C C   . LEU A 1 266 ? 15.25527  3.47927   -37.57172 1.000 2.27903  ? 268 LEU A C   1 
ATOM   2032 O O   . LEU A 1 266 ? 14.96403  2.28462   -37.47060 1.000 1.84334  ? 268 LEU A O   1 
ATOM   2033 C CB  . LEU A 1 266 ? 13.82733  5.21945   -36.45096 1.000 2.25386  ? 268 LEU A CB  1 
ATOM   2034 C CG  . LEU A 1 266 ? 12.51101  4.43872   -36.62080 1.000 4.66429  ? 268 LEU A CG  1 
ATOM   2035 C CD1 . LEU A 1 266 ? 12.37638  3.29268   -35.59646 1.000 2.55300  ? 268 LEU A CD1 1 
ATOM   2036 C CD2 . LEU A 1 266 ? 11.27022  5.36338   -36.58204 1.000 1.49420  ? 268 LEU A CD2 1 
ATOM   2037 N N   . LYS A 1 267 ? 15.68059  4.00228   -38.72259 1.000 2.09830  ? 269 LYS A N   1 
ATOM   2038 C CA  . LYS A 1 267 ? 15.83958  3.12709   -39.88193 1.000 4.60173  ? 269 LYS A CA  1 
ATOM   2039 C C   . LYS A 1 267 ? 16.71735  1.93164   -39.54829 1.000 2.71816  ? 269 LYS A C   1 
ATOM   2040 O O   . LYS A 1 267 ? 16.44445  0.80534   -39.98544 1.000 2.91758  ? 269 LYS A O   1 
ATOM   2041 C CB  . LYS A 1 267 ? 16.43603  3.89576   -41.06289 1.000 4.08223  ? 269 LYS A CB  1 
ATOM   2042 C CG  . LYS A 1 267 ? 15.55610  4.98920   -41.62321 1.000 8.08089  ? 269 LYS A CG  1 
ATOM   2043 C CD  . LYS A 1 267 ? 16.33339  5.93433   -42.54420 1.000 5.61440  ? 269 LYS A CD  1 
ATOM   2044 C CE  . LYS A 1 267 ? 16.72073  5.29208   -43.86079 1.000 5.42181  ? 269 LYS A CE  1 
ATOM   2045 N NZ  . LYS A 1 267 ? 17.48208  6.29854   -44.70854 1.000 7.58960  ? 269 LYS A NZ  1 
ATOM   2046 N N   . GLU A 1 268 ? 17.78713  2.16260   -38.78243 1.000 3.22698  ? 270 GLU A N   1 
ATOM   2047 C CA  . GLU A 1 268 ? 18.71839  1.08468   -38.44605 1.000 4.73839  ? 270 GLU A CA  1 
ATOM   2048 C C   . GLU A 1 268 ? 18.10711  0.11244   -37.44397 1.000 2.98134  ? 270 GLU A C   1 
ATOM   2049 O O   . GLU A 1 268 ? 18.28615  -1.10670  -37.57010 1.000 4.51917  ? 270 GLU A O   1 
ATOM   2050 C CB  . GLU A 1 268 ? 20.03183  1.67039   -37.89997 1.000 5.69629  ? 270 GLU A CB  1 
ATOM   2051 C CG  . GLU A 1 268 ? 21.10562  0.63093   -37.59111 1.000 5.13334  ? 270 GLU A CG  1 
ATOM   2052 C CD  . GLU A 1 268 ? 22.48809  1.24809   -37.28885 1.000 8.39927  ? 270 GLU A CD  1 
ATOM   2053 O OE1 . GLU A 1 268 ? 22.79216  1.49320   -36.10223 1.000 6.86750  ? 270 GLU A OE1 1 
ATOM   2054 O OE2 . GLU A 1 268 ? 23.26649  1.49308   -38.24226 1.000 4.97198  ? 270 GLU A OE2 1 
ATOM   2055 N N   . LEU A 1 269 ? 17.38018  0.63229   -36.44166 1.000 5.01404  ? 271 LEU A N   1 
ATOM   2056 C CA  . LEU A 1 269 ? 16.69855  -0.24281  -35.48484 1.000 5.37343  ? 271 LEU A CA  1 
ATOM   2057 C C   . LEU A 1 269 ? 15.71217  -1.16028  -36.18861 1.000 5.26757  ? 271 LEU A C   1 
ATOM   2058 O O   . LEU A 1 269 ? 15.58032  -2.33158  -35.82032 1.000 8.21383  ? 271 LEU A O   1 
ATOM   2059 C CB  . LEU A 1 269 ? 15.98701  0.56853   -34.39381 1.000 4.36307  ? 271 LEU A CB  1 
ATOM   2060 C CG  . LEU A 1 269 ? 16.83831  1.17640   -33.26511 1.000 7.96627  ? 271 LEU A CG  1 
ATOM   2061 C CD1 . LEU A 1 269 ? 16.15190  2.40628   -32.63015 1.000 4.09103  ? 271 LEU A CD1 1 
ATOM   2062 C CD2 . LEU A 1 269 ? 17.24255  0.14355   -32.18777 1.000 6.12620  ? 271 LEU A CD2 1 
ATOM   2063 N N   . LEU A 1 270 ? 15.03316  -0.66735  -37.22737 1.000 4.11998  ? 272 LEU A N   1 
ATOM   2064 C CA  . LEU A 1 270 ? 14.13380  -1.55274  -37.96700 1.000 3.57125  ? 272 LEU A CA  1 
ATOM   2065 C C   . LEU A 1 270 ? 14.92044  -2.62697  -38.70973 1.000 4.49190  ? 272 LEU A C   1 
ATOM   2066 O O   . LEU A 1 270 ? 14.47490  -3.77215  -38.83175 1.000 3.76338  ? 272 LEU A O   1 
ATOM   2067 C CB  . LEU A 1 270 ? 13.27202  -0.74034  -38.94275 1.000 2.83991  ? 272 LEU A CB  1 
ATOM   2068 C CG  . LEU A 1 270 ? 12.32882  0.29427   -38.32446 1.000 4.84765  ? 272 LEU A CG  1 
ATOM   2069 C CD1 . LEU A 1 270 ? 11.97417  1.39943   -39.31317 1.000 4.86953  ? 272 LEU A CD1 1 
ATOM   2070 C CD2 . LEU A 1 270 ? 11.07204  -0.39462  -37.79133 1.000 3.77492  ? 272 LEU A CD2 1 
ATOM   2071 N N   . GLN A 1 271 ? 16.09614  -2.27029  -39.21359 1.000 4.28836  ? 273 GLN A N   1 
ATOM   2072 C CA  . GLN A 1 271 ? 16.90784  -3.21054  -39.98074 1.000 3.72857  ? 273 GLN A CA  1 
ATOM   2073 C C   . GLN A 1 271 ? 17.46888  -4.32524  -39.10027 1.000 4.52225  ? 273 GLN A C   1 
ATOM   2074 O O   . GLN A 1 271 ? 17.45027  -5.49810  -39.49375 1.000 3.93809  ? 273 GLN A O   1 
ATOM   2075 C CB  . GLN A 1 271 ? 18.01696  -2.41797  -40.67042 1.000 3.62392  ? 273 GLN A CB  1 
ATOM   2076 C CG  . GLN A 1 271 ? 19.10176  -3.19490  -41.32986 1.000 6.37960  ? 273 GLN A CG  1 
ATOM   2077 C CD  . GLN A 1 271 ? 20.20345  -2.26814  -41.79816 1.000 7.15664  ? 273 GLN A CD  1 
ATOM   2078 O OE1 . GLN A 1 271 ? 20.13671  -1.69150  -42.89158 1.000 13.99698 ? 273 GLN A OE1 1 
ATOM   2079 N NE2 . GLN A 1 271 ? 21.19779  -2.07440  -40.95092 1.000 5.08089  ? 273 GLN A NE2 1 
ATOM   2080 N N   . ASN A 1 272 ? 17.95194  -3.98087  -37.89414 1.000 6.17666  ? 274 ASN A N   1 
ATOM   2081 C CA  . ASN A 1 272 ? 18.67665  -4.91254  -37.02579 1.000 6.67175  ? 274 ASN A CA  1 
ATOM   2082 C C   . ASN A 1 272 ? 17.85577  -5.50691  -35.88492 1.000 10.45919 ? 274 ASN A C   1 
ATOM   2083 O O   . ASN A 1 272 ? 18.22829  -6.56699  -35.37533 1.000 11.98229 ? 274 ASN A O   1 
ATOM   2084 C CB  . ASN A 1 272 ? 19.89860  -4.23156  -36.38911 1.000 6.73178  ? 274 ASN A CB  1 
ATOM   2085 C CG  . ASN A 1 272 ? 20.83587  -3.61719  -37.41589 1.000 5.33972  ? 274 ASN A CG  1 
ATOM   2086 O OD1 . ASN A 1 272 ? 20.86104  -4.02707  -38.57000 1.000 6.21163  ? 274 ASN A OD1 1 
ATOM   2087 N ND2 . ASN A 1 272 ? 21.57592  -2.60339  -37.00538 1.000 5.69551  ? 274 ASN A ND2 1 
ATOM   2088 N N   . GLY A 1 273 ? 16.77666  -4.85877  -35.45271 1.000 12.34168 ? 275 GLY A N   1 
ATOM   2089 C CA  . GLY A 1 273 ? 16.17306  -5.24812  -34.18659 1.000 10.30198 ? 275 GLY A CA  1 
ATOM   2090 C C   . GLY A 1 273 ? 17.07222  -4.72866  -33.07004 1.000 11.03738 ? 275 GLY A C   1 
ATOM   2091 O O   . GLY A 1 273 ? 17.99377  -3.95260  -33.29146 1.000 8.76928  ? 275 GLY A O   1 
ATOM   2092 N N   . MET A 1 274 ? 16.80539  -5.18052  -31.85109 1.000 11.44372 ? 276 MET A N   1 
ATOM   2093 C CA  . MET A 1 274 ? 17.52866  -4.60709  -30.72388 1.000 13.27290 ? 276 MET A CA  1 
ATOM   2094 C C   . MET A 1 274 ? 18.68190  -5.47261  -30.22615 1.000 15.25439 ? 276 MET A C   1 
ATOM   2095 O O   . MET A 1 274 ? 19.42345  -5.03160  -29.34309 1.000 16.18058 ? 276 MET A O   1 
ATOM   2096 C CB  . MET A 1 274 ? 16.55227  -4.31230  -29.57977 1.000 18.74919 ? 276 MET A CB  1 
ATOM   2097 C CG  . MET A 1 274 ? 15.52364  -3.24767  -29.93681 1.000 8.78598  ? 276 MET A CG  1 
ATOM   2098 S SD  . MET A 1 274 ? 14.59089  -2.82673  -28.48581 1.000 29.86625 ? 276 MET A SD  1 
ATOM   2099 C CE  . MET A 1 274 ? 13.21564  -1.93083  -29.19785 1.000 17.15945 ? 276 MET A CE  1 
ATOM   2100 N N   . ASN A 1 275 ? 18.85214  -6.67219  -30.77470 1.000 18.49702 ? 277 ASN A N   1 
ATOM   2101 C CA  . ASN A 1 275 ? 19.93836  -7.58443  -30.42176 1.000 20.05561 ? 277 ASN A CA  1 
ATOM   2102 C C   . ASN A 1 275 ? 20.01060  -7.78821  -28.90350 1.000 23.86927 ? 277 ASN A C   1 
ATOM   2103 O O   . ASN A 1 275 ? 20.99963  -7.47486  -28.23876 1.000 18.61087 ? 277 ASN A O   1 
ATOM   2104 C CB  . ASN A 1 275 ? 21.26223  -7.08673  -31.01823 1.000 22.79639 ? 277 ASN A CB  1 
ATOM   2105 C CG  . ASN A 1 275 ? 21.22517  -7.04480  -32.56559 1.000 28.55891 ? 277 ASN A CG  1 
ATOM   2106 O OD1 . ASN A 1 275 ? 21.50100  -6.01049  -33.19733 1.000 20.77188 ? 277 ASN A OD1 1 
ATOM   2107 N ND2 . ASN A 1 275 ? 20.85376  -8.17334  -33.17258 1.000 26.38175 ? 277 ASN A ND2 1 
ATOM   2108 N N   . GLY A 1 276 ? 18.91078  -8.30783  -28.35838 1.000 22.31617 ? 278 GLY A N   1 
ATOM   2109 C CA  . GLY A 1 276 ? 18.83802  -8.63590  -26.95064 1.000 22.90549 ? 278 GLY A CA  1 
ATOM   2110 C C   . GLY A 1 276 ? 18.74573  -7.46176  -26.00189 1.000 21.33270 ? 278 GLY A C   1 
ATOM   2111 O O   . GLY A 1 276 ? 18.61173  -7.67745  -24.79379 1.000 27.11158 ? 278 GLY A O   1 
ATOM   2112 N N   . ARG A 1 277 ? 18.80290  -6.23118  -26.49404 1.000 16.53419 ? 279 ARG A N   1 
ATOM   2113 C CA  . ARG A 1 277 ? 18.76602  -5.08075  -25.61474 1.000 13.27101 ? 279 ARG A CA  1 
ATOM   2114 C C   . ARG A 1 277 ? 17.33047  -4.58232  -25.44386 1.000 18.20844 ? 279 ARG A C   1 
ATOM   2115 O O   . ARG A 1 277 ? 16.37013  -5.14877  -25.96841 1.000 16.47137 ? 279 ARG A O   1 
ATOM   2116 C CB  . ARG A 1 277 ? 19.68197  -3.97385  -26.13509 1.000 16.13883 ? 279 ARG A CB  1 
ATOM   2117 C CG  . ARG A 1 277 ? 21.16353  -4.23369  -25.88159 1.000 19.70036 ? 279 ARG A CG  1 
ATOM   2118 C CD  . ARG A 1 277 ? 22.03505  -3.31435  -26.70978 1.000 18.92147 ? 279 ARG A CD  1 
ATOM   2119 N NE  . ARG A 1 277 ? 21.83110  -3.54177  -28.14063 1.000 27.71688 ? 279 ARG A NE  1 
ATOM   2120 C CZ  . ARG A 1 277 ? 22.68698  -3.17229  -29.09391 1.000 28.26252 ? 279 ARG A CZ  1 
ATOM   2121 N NH1 . ARG A 1 277 ? 23.82114  -2.56042  -28.77113 1.000 26.81460 ? 279 ARG A NH1 1 
ATOM   2122 N NH2 . ARG A 1 277 ? 22.41168  -3.41913  -30.37233 1.000 25.42154 ? 279 ARG A NH2 1 
ATOM   2123 N N   . THR A 1 278 ? 17.19892  -3.49425  -24.69452 1.000 14.07635 ? 280 THR A N   1 
ATOM   2124 C CA  . THR A 1 278 ? 15.92457  -2.93777  -24.30539 1.000 13.25548 ? 280 THR A CA  1 
ATOM   2125 C C   . THR A 1 278 ? 16.00716  -1.41882  -24.40290 1.000 14.89931 ? 280 THR A C   1 
ATOM   2126 O O   . THR A 1 278 ? 17.09066  -0.83563  -24.31045 1.000 16.21264 ? 280 THR A O   1 
ATOM   2127 C CB  . THR A 1 278 ? 15.57813  -3.39116  -22.88244 1.000 17.28841 ? 280 THR A CB  1 
ATOM   2128 O OG1 . THR A 1 278 ? 14.16737  -3.39782  -22.72898 1.000 22.23314 ? 280 THR A OG1 1 
ATOM   2129 C CG2 . THR A 1 278 ? 16.19713  -2.46042  -21.84605 1.000 15.30248 ? 280 THR A CG2 1 
ATOM   2130 N N   . ILE A 1 279 ? 14.86348  -0.77273  -24.61285 1.000 15.36987 ? 281 ILE A N   1 
ATOM   2131 C CA  . ILE A 1 279 ? 14.79831  0.68592   -24.63457 1.000 11.28712 ? 281 ILE A CA  1 
ATOM   2132 C C   . ILE A 1 279 ? 13.67629  1.11096   -23.69816 1.000 15.63666 ? 281 ILE A C   1 
ATOM   2133 O O   . ILE A 1 279 ? 12.50249  0.82139   -23.95778 1.000 15.14843 ? 281 ILE A O   1 
ATOM   2134 C CB  . ILE A 1 279 ? 14.58266  1.24497   -26.04935 1.000 11.20144 ? 281 ILE A CB  1 
ATOM   2135 C CG1 . ILE A 1 279 ? 15.77863  0.89391   -26.95099 1.000 11.52867 ? 281 ILE A CG1 1 
ATOM   2136 C CG2 . ILE A 1 279 ? 14.40076  2.74905   -25.99284 1.000 12.69127 ? 281 ILE A CG2 1 
ATOM   2137 C CD1 . ILE A 1 279 ? 15.68513  1.43987   -28.38902 1.000 9.20258  ? 281 ILE A CD1 1 
ATOM   2138 N N   . LEU A 1 280 ? 14.03790  1.78048   -22.60486 1.000 16.52033 ? 282 LEU A N   1 
ATOM   2139 C CA  . LEU A 1 280 ? 13.09809  2.24568   -21.58535 1.000 19.23518 ? 282 LEU A CA  1 
ATOM   2140 C C   . LEU A 1 280 ? 12.30646  1.09649   -20.97256 1.000 20.96381 ? 282 LEU A C   1 
ATOM   2141 O O   . LEU A 1 280 ? 11.24311  1.31457   -20.38455 1.000 38.84396 ? 282 LEU A O   1 
ATOM   2142 C CB  . LEU A 1 280 ? 12.14448  3.29145   -22.16083 1.000 16.66823 ? 282 LEU A CB  1 
ATOM   2143 C CG  . LEU A 1 280 ? 12.86158  4.59219   -22.50766 1.000 18.24200 ? 282 LEU A CG  1 
ATOM   2144 C CD1 . LEU A 1 280 ? 11.96281  5.52091   -23.27808 1.000 11.26337 ? 282 LEU A CD1 1 
ATOM   2145 C CD2 . LEU A 1 280 ? 13.39675  5.26343   -21.25365 1.000 18.24039 ? 282 LEU A CD2 1 
ATOM   2146 N N   . GLY A 1 281 ? 12.81825  -0.12363  -21.09358 1.000 17.16722 ? 283 GLY A N   1 
ATOM   2147 C CA  . GLY A 1 281 ? 12.16952  -1.27380  -20.50200 1.000 17.11662 ? 283 GLY A CA  1 
ATOM   2148 C C   . GLY A 1 281 ? 11.51385  -2.21500  -21.48690 1.000 19.98394 ? 283 GLY A C   1 
ATOM   2149 O O   . GLY A 1 281 ? 11.04234  -3.29044  -21.10437 1.000 25.36842 ? 283 GLY A O   1 
ATOM   2150 N N   . SER A 1 282 ? 11.48741  -1.84343  -22.76104 1.000 19.69849 ? 284 SER A N   1 
ATOM   2151 C CA  . SER A 1 282 ? 10.75278  -2.60462  -23.75589 1.000 18.06408 ? 284 SER A CA  1 
ATOM   2152 C C   . SER A 1 282 ? 11.70433  -3.16798  -24.79964 1.000 16.30270 ? 284 SER A C   1 
ATOM   2153 O O   . SER A 1 282 ? 12.72583  -2.55970  -25.12950 1.000 18.55328 ? 284 SER A O   1 
ATOM   2154 C CB  . SER A 1 282 ? 9.68405   -1.73677  -24.43149 1.000 11.46011 ? 284 SER A CB  1 
ATOM   2155 O OG  . SER A 1 282 ? 9.07651   -2.43689  -25.50156 1.000 16.42187 ? 284 SER A OG  1 
ATOM   2156 N N   . ALA A 1 283 ? 11.35539  -4.34412  -25.31288 1.000 17.63567 ? 285 ALA A N   1 
ATOM   2157 C CA  . ALA A 1 283 ? 12.03576  -4.92760  -26.45703 1.000 20.29245 ? 285 ALA A CA  1 
ATOM   2158 C C   . ALA A 1 283 ? 11.31272  -4.65878  -27.77034 1.000 16.11613 ? 285 ALA A C   1 
ATOM   2159 O O   . ALA A 1 283 ? 11.72416  -5.18735  -28.80366 1.000 17.14916 ? 285 ALA A O   1 
ATOM   2160 C CB  . ALA A 1 283 ? 12.21107  -6.43171  -26.25527 1.000 13.21684 ? 285 ALA A CB  1 
ATOM   2161 N N   . LEU A 1 284 ? 10.23869  -3.87072  -27.75065 1.000 16.96826 ? 286 LEU A N   1 
ATOM   2162 C CA  . LEU A 1 284 ? 9.56181   -3.39613  -28.95101 1.000 14.17385 ? 286 LEU A CA  1 
ATOM   2163 C C   . LEU A 1 284 ? 9.70198   -1.88493  -29.04898 1.000 10.60024 ? 286 LEU A C   1 
ATOM   2164 O O   . LEU A 1 284 ? 9.87158   -1.19260  -28.04085 1.000 10.62127 ? 286 LEU A O   1 
ATOM   2165 C CB  . LEU A 1 284 ? 8.07363   -3.77345  -28.93275 1.000 19.17032 ? 286 LEU A CB  1 
ATOM   2166 C CG  . LEU A 1 284 ? 7.62862   -5.05671  -29.62192 1.000 14.56104 ? 286 LEU A CG  1 
ATOM   2167 C CD1 . LEU A 1 284 ? 8.60103   -6.18629  -29.38429 1.000 26.62782 ? 286 LEU A CD1 1 
ATOM   2168 C CD2 . LEU A 1 284 ? 6.24587   -5.43754  -29.12854 1.000 20.43571 ? 286 LEU A CD2 1 
ATOM   2169 N N   . LEU A 1 285 ? 9.60587   -1.36870  -30.27057 1.000 6.01343  ? 287 LEU A N   1 
ATOM   2170 C CA  . LEU A 1 285 ? 9.54678   0.07605   -30.44675 1.000 6.81431  ? 287 LEU A CA  1 
ATOM   2171 C C   . LEU A 1 285 ? 8.14613   0.54472   -30.06121 1.000 9.99881  ? 287 LEU A C   1 
ATOM   2172 O O   . LEU A 1 285 ? 7.15723   0.06241   -30.61436 1.000 8.26742  ? 287 LEU A O   1 
ATOM   2173 C CB  . LEU A 1 285 ? 9.87978   0.44576   -31.88891 1.000 7.64089  ? 287 LEU A CB  1 
ATOM   2174 C CG  . LEU A 1 285 ? 11.22690  -0.09221  -32.40376 1.000 5.59060  ? 287 LEU A CG  1 
ATOM   2175 C CD1 . LEU A 1 285 ? 11.32591  0.13957   -33.89030 1.000 4.21414  ? 287 LEU A CD1 1 
ATOM   2176 C CD2 . LEU A 1 285 ? 12.36784  0.59801   -31.68341 1.000 5.32697  ? 287 LEU A CD2 1 
ATOM   2177 N N   . GLU A 1 286 ? 8.05444   1.43023   -29.07268 1.000 12.00864 ? 288 GLU A N   1 
ATOM   2178 C CA  . GLU A 1 286 ? 6.76999   1.82306   -28.50337 1.000 10.35553 ? 288 GLU A CA  1 
ATOM   2179 C C   . GLU A 1 286 ? 6.20607   2.99651   -29.28675 1.000 11.58900 ? 288 GLU A C   1 
ATOM   2180 O O   . GLU A 1 286 ? 6.93814   3.93023   -29.62719 1.000 9.39176  ? 288 GLU A O   1 
ATOM   2181 C CB  . GLU A 1 286 ? 6.93900   2.19233   -27.03019 1.000 10.93105 ? 288 GLU A CB  1 
ATOM   2182 C CG  . GLU A 1 286 ? 5.72205   2.81095   -26.38666 1.000 20.24208 ? 288 GLU A CG  1 
ATOM   2183 C CD  . GLU A 1 286 ? 4.49595   1.89381   -26.42051 1.000 25.36791 ? 288 GLU A CD  1 
ATOM   2184 O OE1 . GLU A 1 286 ? 3.41668   2.35040   -26.88444 1.000 11.51196 ? 288 GLU A OE1 1 
ATOM   2185 O OE2 . GLU A 1 286 ? 4.62301   0.71690   -25.99021 1.000 26.71623 ? 288 GLU A OE2 1 
ATOM   2186 N N   . ASP A 1 287 ? 4.89868   2.94706   -29.59106 1.000 7.50574  ? 289 ASP A N   1 
ATOM   2187 C CA  . ASP A 1 287 ? 4.31765   4.02658   -30.38389 1.000 7.51912  ? 289 ASP A CA  1 
ATOM   2188 C C   . ASP A 1 287 ? 3.07701   4.66213   -29.75033 1.000 5.33371  ? 289 ASP A C   1 
ATOM   2189 O O   . ASP A 1 287 ? 2.29917   5.29063   -30.46451 1.000 2.35466  ? 289 ASP A O   1 
ATOM   2190 C CB  . ASP A 1 287 ? 4.01043   3.54609   -31.81653 1.000 5.71687  ? 289 ASP A CB  1 
ATOM   2191 C CG  . ASP A 1 287 ? 2.75013   2.71057   -31.91948 1.000 4.73511  ? 289 ASP A CG  1 
ATOM   2192 O OD1 . ASP A 1 287 ? 2.23595   2.21773   -30.89067 1.000 6.11382  ? 289 ASP A OD1 1 
ATOM   2193 O OD2 . ASP A 1 287 ? 2.27094   2.53412   -33.06211 1.000 6.33315  ? 289 ASP A OD2 1 
ATOM   2194 N N   . GLU A 1 288 ? 2.87926   4.55193   -28.42699 1.000 7.72624  ? 290 GLU A N   1 
ATOM   2195 C CA  . GLU A 1 288 ? 1.72195   5.18297   -27.78768 1.000 9.79092  ? 290 GLU A CA  1 
ATOM   2196 C C   . GLU A 1 288 ? 2.13238   6.22270   -26.73787 1.000 6.86828  ? 290 GLU A C   1 
ATOM   2197 O O   . GLU A 1 288 ? 1.39759   6.46153   -25.77611 1.000 5.72765  ? 290 GLU A O   1 
ATOM   2198 C CB  . GLU A 1 288 ? 0.76361   4.12698   -27.20291 1.000 6.19163  ? 290 GLU A CB  1 
ATOM   2199 C CG  . GLU A 1 288 ? 0.13384   3.21061   -28.31645 1.000 7.64001  ? 290 GLU A CG  1 
ATOM   2200 C CD  . GLU A 1 288 ? -1.28907  2.68187   -28.03197 1.000 13.00740 ? 290 GLU A CD  1 
ATOM   2201 O OE1 . GLU A 1 288 ? -1.70044  2.57014   -26.84990 1.000 12.59650 ? 290 GLU A OE1 1 
ATOM   2202 O OE2 . GLU A 1 288 ? -2.00501  2.35727   -29.01255 1.000 11.44564 ? 290 GLU A OE2 1 
ATOM   2203 N N   . PHE A 1 289 ? 3.29364   6.86291   -26.92257 1.000 5.71032  ? 291 PHE A N   1 
ATOM   2204 C CA  . PHE A 1 289 ? 3.70783   8.06437   -26.19300 1.000 6.66753  ? 291 PHE A CA  1 
ATOM   2205 C C   . PHE A 1 289 ? 3.90088   9.20183   -27.18531 1.000 7.79883  ? 291 PHE A C   1 
ATOM   2206 O O   . PHE A 1 289 ? 4.71252   9.07630   -28.10776 1.000 7.39120  ? 291 PHE A O   1 
ATOM   2207 C CB  . PHE A 1 289 ? 5.04407   7.90034   -25.45577 1.000 8.93519  ? 291 PHE A CB  1 
ATOM   2208 C CG  . PHE A 1 289 ? 5.02810   6.93796   -24.32071 1.000 16.83989 ? 291 PHE A CG  1 
ATOM   2209 C CD1 . PHE A 1 289 ? 4.64782   7.34453   -23.05140 1.000 17.43807 ? 291 PHE A CD1 1 
ATOM   2210 C CD2 . PHE A 1 289 ? 5.46501   5.62852   -24.50362 1.000 22.90118 ? 291 PHE A CD2 1 
ATOM   2211 C CE1 . PHE A 1 289 ? 4.66367   6.44779   -21.98093 1.000 23.20378 ? 291 PHE A CE1 1 
ATOM   2212 C CE2 . PHE A 1 289 ? 5.47563   4.72472   -23.44438 1.000 23.60287 ? 291 PHE A CE2 1 
ATOM   2213 C CZ  . PHE A 1 289 ? 5.07269   5.13886   -22.17817 1.000 22.10800 ? 291 PHE A CZ  1 
ATOM   2214 N N   . THR A 1 290 ? 3.22889   10.34098  -26.95460 1.000 6.84124  ? 292 THR A N   1 
ATOM   2215 C CA  . THR A 1 290 ? 3.34193   11.46327  -27.88115 1.000 9.84547  ? 292 THR A CA  1 
ATOM   2216 C C   . THR A 1 290 ? 4.49940   12.38926  -27.51544 1.000 7.34405  ? 292 THR A C   1 
ATOM   2217 O O   . THR A 1 290 ? 5.03779   12.32995  -26.40699 1.000 8.57406  ? 292 THR A O   1 
ATOM   2218 C CB  . THR A 1 290 ? 2.04672   12.27499  -27.89916 1.000 5.58527  ? 292 THR A CB  1 
ATOM   2219 O OG1 . THR A 1 290 ? 1.82158   12.82218  -26.59519 1.000 8.75870  ? 292 THR A OG1 1 
ATOM   2220 C CG2 . THR A 1 290 ? 0.85418   11.42327  -28.35277 1.000 4.71007  ? 292 THR A CG2 1 
ATOM   2221 N N   . PRO A 1 291 ? 4.90731   13.27141  -28.43721 1.000 8.77346  ? 293 PRO A N   1 
ATOM   2222 C CA  . PRO A 1 291 ? 5.88066   14.31429  -28.05821 1.000 11.39195 ? 293 PRO A CA  1 
ATOM   2223 C C   . PRO A 1 291 ? 5.44516   15.12130  -26.84368 1.000 12.68607 ? 293 PRO A C   1 
ATOM   2224 O O   . PRO A 1 291 ? 6.29243   15.52915  -26.03016 1.000 11.26437 ? 293 PRO A O   1 
ATOM   2225 C CB  . PRO A 1 291 ? 5.97792   15.17908  -29.32423 1.000 8.60784  ? 293 PRO A CB  1 
ATOM   2226 C CG  . PRO A 1 291 ? 5.61138   14.26166  -30.44506 1.000 9.78601  ? 293 PRO A CG  1 
ATOM   2227 C CD  . PRO A 1 291 ? 4.61294   13.28098  -29.88811 1.000 5.52995  ? 293 PRO A CD  1 
ATOM   2228 N N   . PHE A 1 292 ? 4.13581   15.34206  -26.68784 1.000 12.59294 ? 294 PHE A N   1 
ATOM   2229 C CA  . PHE A 1 292 ? 3.61183   16.02304  -25.50897 1.000 11.82369 ? 294 PHE A CA  1 
ATOM   2230 C C   . PHE A 1 292 ? 3.74667   15.14727  -24.26064 1.000 11.88879 ? 294 PHE A C   1 
ATOM   2231 O O   . PHE A 1 292 ? 4.19021   15.61866  -23.20903 1.000 15.97634 ? 294 PHE A O   1 
ATOM   2232 C CB  . PHE A 1 292 ? 2.15766   16.40767  -25.76930 1.000 15.69006 ? 294 PHE A CB  1 
ATOM   2233 C CG  . PHE A 1 292 ? 1.61317   17.47553  -24.85031 1.000 27.36965 ? 294 PHE A CG  1 
ATOM   2234 C CD1 . PHE A 1 292 ? 1.13200   17.14965  -23.58009 1.000 26.23558 ? 294 PHE A CD1 1 
ATOM   2235 C CD2 . PHE A 1 292 ? 1.52238   18.80000  -25.27778 1.000 30.66883 ? 294 PHE A CD2 1 
ATOM   2236 C CE1 . PHE A 1 292 ? 0.60158   18.13438  -22.73174 1.000 28.70006 ? 294 PHE A CE1 1 
ATOM   2237 C CE2 . PHE A 1 292 ? 0.99028   19.78948  -24.43754 1.000 35.55755 ? 294 PHE A CE2 1 
ATOM   2238 C CZ  . PHE A 1 292 ? 0.52934   19.45222  -23.16339 1.000 31.76636 ? 294 PHE A CZ  1 
ATOM   2239 N N   . ASP A 1 293 ? 3.38841   13.86102  -24.35938 1.000 8.06238  ? 295 ASP A N   1 
ATOM   2240 C CA  . ASP A 1 293 ? 3.53384   12.95952  -23.21407 1.000 7.92985  ? 295 ASP A CA  1 
ATOM   2241 C C   . ASP A 1 293 ? 4.98003   12.89799  -22.72069 1.000 13.42965 ? 295 ASP A C   1 
ATOM   2242 O O   . ASP A 1 293 ? 5.22777   12.75420  -21.51531 1.000 9.78739  ? 295 ASP A O   1 
ATOM   2243 C CB  . ASP A 1 293 ? 3.06953   11.54893  -23.57198 1.000 5.35619  ? 295 ASP A CB  1 
ATOM   2244 C CG  . ASP A 1 293 ? 1.60680   11.47771  -23.96321 1.000 10.93243 ? 295 ASP A CG  1 
ATOM   2245 O OD1 . ASP A 1 293 ? 0.82210   12.40275  -23.63869 1.000 11.05329 ? 295 ASP A OD1 1 
ATOM   2246 O OD2 . ASP A 1 293 ? 1.24388   10.45907  -24.58598 1.000 5.87647  ? 295 ASP A OD2 1 
ATOM   2247 N N   . VAL A 1 294 ? 5.94534   12.95083  -23.64384 1.000 9.58303  ? 296 VAL A N   1 
ATOM   2248 C CA  . VAL A 1 294 ? 7.35051   12.85591  -23.25690 1.000 11.82833 ? 296 VAL A CA  1 
ATOM   2249 C C   . VAL A 1 294 ? 7.72899   14.02540  -22.36654 1.000 14.45237 ? 296 VAL A C   1 
ATOM   2250 O O   . VAL A 1 294 ? 8.28145   13.84419  -21.27367 1.000 17.34158 ? 296 VAL A O   1 
ATOM   2251 C CB  . VAL A 1 294 ? 8.24952   12.78465  -24.50560 1.000 8.58664  ? 296 VAL A CB  1 
ATOM   2252 C CG1 . VAL A 1 294 ? 9.69972   13.10020  -24.15010 1.000 13.19309 ? 296 VAL A CG1 1 
ATOM   2253 C CG2 . VAL A 1 294 ? 8.13838   11.41826  -25.14786 1.000 6.00679  ? 296 VAL A CG2 1 
ATOM   2254 N N   . VAL A 1 295 ? 7.42689   15.24510  -22.81945 1.000 16.77743 ? 297 VAL A N   1 
ATOM   2255 C CA  . VAL A 1 295 ? 7.76082   16.43905  -22.04890 1.000 20.34681 ? 297 VAL A CA  1 
ATOM   2256 C C   . VAL A 1 295 ? 7.05175   16.44114  -20.69647 1.000 25.18330 ? 297 VAL A C   1 
ATOM   2257 O O   . VAL A 1 295 ? 7.60528   16.92013  -19.69797 1.000 27.48671 ? 297 VAL A O   1 
ATOM   2258 C CB  . VAL A 1 295 ? 7.43311   17.69758  -22.87245 1.000 16.30332 ? 297 VAL A CB  1 
ATOM   2259 C CG1 . VAL A 1 295 ? 7.73626   18.95574  -22.07425 1.000 20.37310 ? 297 VAL A CG1 1 
ATOM   2260 C CG2 . VAL A 1 295 ? 8.24506   17.70077  -24.15442 1.000 15.98955 ? 297 VAL A CG2 1 
ATOM   2261 N N   . ARG A 1 296 ? 5.83814   15.88752  -20.62556 1.000 18.48762 ? 298 ARG A N   1 
ATOM   2262 C CA  . ARG A 1 296 ? 5.13077   15.85840  -19.34862 1.000 21.22221 ? 298 ARG A CA  1 
ATOM   2263 C C   . ARG A 1 296 ? 5.83041   14.94148  -18.35026 1.000 27.08885 ? 298 ARG A C   1 
ATOM   2264 O O   . ARG A 1 296 ? 6.04810   15.32379  -17.19689 1.000 28.29544 ? 298 ARG A O   1 
ATOM   2265 C CB  . ARG A 1 296 ? 3.67578   15.43269  -19.55847 1.000 17.00920 ? 298 ARG A CB  1 
ATOM   2266 N N   . GLN A 1 297 ? 6.20977   13.73921  -18.77479 1.000 21.89174 ? 299 GLN A N   1 
ATOM   2267 C CA  . GLN A 1 297 ? 6.79448   12.78505  -17.84628 1.000 21.55702 ? 299 GLN A CA  1 
ATOM   2268 C C   . GLN A 1 297 ? 8.23537   13.13707  -17.45477 1.000 31.57619 ? 299 GLN A C   1 
ATOM   2269 O O   . GLN A 1 297 ? 8.70415   12.65739  -16.41678 1.000 36.63766 ? 299 GLN A O   1 
ATOM   2270 C CB  . GLN A 1 297 ? 6.71526   11.37860  -18.44534 1.000 24.28798 ? 299 GLN A CB  1 
ATOM   2271 C CG  . GLN A 1 297 ? 7.18800   10.25332  -17.53654 1.000 30.78599 ? 299 GLN A CG  1 
ATOM   2272 C CD  . GLN A 1 297 ? 6.54100   8.93045   -17.89177 1.000 29.36726 ? 299 GLN A CD  1 
ATOM   2273 O OE1 . GLN A 1 297 ? 7.08217   7.84933   -17.61622 1.000 30.63264 ? 299 GLN A OE1 1 
ATOM   2274 N NE2 . GLN A 1 297 ? 5.36292   9.00793   -18.49573 1.000 28.50526 ? 299 GLN A NE2 1 
ATOM   2275 N N   . CYS A 1 298 ? 8.93814   13.98517  -18.21808 1.000 24.38247 ? 300 CYS A N   1 
ATOM   2276 C CA  . CYS A 1 298 ? 10.26559  14.45065  -17.79688 1.000 32.42520 ? 300 CYS A CA  1 
ATOM   2277 C C   . CYS A 1 298 ? 10.30851  15.95404  -17.46768 1.000 31.82131 ? 300 CYS A C   1 
ATOM   2278 O O   . CYS A 1 298 ? 9.42706   16.50119  -16.79820 1.000 30.96167 ? 300 CYS A O   1 
ATOM   2279 C CB  . CYS A 1 298 ? 11.31617  14.15236  -18.87557 1.000 36.42658 ? 300 CYS A CB  1 
ATOM   2280 S SG  . CYS A 1 298 ? 11.11590  12.63632  -19.88421 1.000 52.00988 ? 300 CYS A SG  1 
ATOM   2281 N N   . PHE B 1 1   ? -4.76328  -6.97627  -23.70374 1.000 48.79561 ? 3   PHE B N   1 
ATOM   2282 C CA  . PHE B 1 1   ? -4.39941  -7.00942  -22.28923 1.000 32.57445 ? 3   PHE B CA  1 
ATOM   2283 C C   . PHE B 1 1   ? -3.60430  -5.76517  -21.92066 1.000 31.96013 ? 3   PHE B C   1 
ATOM   2284 O O   . PHE B 1 1   ? -2.57035  -5.47663  -22.52865 1.000 36.55207 ? 3   PHE B O   1 
ATOM   2285 C CB  . PHE B 1 1   ? -3.59287  -8.27282  -21.96123 1.000 33.46201 ? 3   PHE B CB  1 
ATOM   2286 C CG  . PHE B 1 1   ? -3.82038  -8.78186  -20.57027 1.000 26.08260 ? 3   PHE B CG  1 
ATOM   2287 C CD1 . PHE B 1 1   ? -5.09667  -9.11783  -20.15187 1.000 24.51752 ? 3   PHE B CD1 1 
ATOM   2288 C CD2 . PHE B 1 1   ? -2.76927  -8.89732  -19.67282 1.000 21.70431 ? 3   PHE B CD2 1 
ATOM   2289 C CE1 . PHE B 1 1   ? -5.32919  -9.57146  -18.86562 1.000 20.74043 ? 3   PHE B CE1 1 
ATOM   2290 C CE2 . PHE B 1 1   ? -2.99129  -9.35213  -18.38370 1.000 23.16193 ? 3   PHE B CE2 1 
ATOM   2291 C CZ  . PHE B 1 1   ? -4.28525  -9.68986  -17.97879 1.000 23.78397 ? 3   PHE B CZ  1 
ATOM   2292 N N   . ARG B 1 2   ? -4.07710  -5.02985  -20.91641 1.000 23.84185 ? 4   ARG B N   1 
ATOM   2293 C CA  . ARG B 1 2   ? -3.45403  -3.77065  -20.54217 1.000 19.17562 ? 4   ARG B CA  1 
ATOM   2294 C C   . ARG B 1 2   ? -3.03699  -3.79069  -19.07322 1.000 15.93200 ? 4   ARG B C   1 
ATOM   2295 O O   . ARG B 1 2   ? -3.64459  -4.46545  -18.23666 1.000 13.12638 ? 4   ARG B O   1 
ATOM   2296 C CB  . ARG B 1 2   ? -4.40882  -2.59280  -20.82857 1.000 14.56414 ? 4   ARG B CB  1 
ATOM   2297 C CG  . ARG B 1 2   ? -4.51393  -2.22694  -22.32958 1.000 16.75693 ? 4   ARG B CG  1 
ATOM   2298 C CD  . ARG B 1 2   ? -4.05504  -0.79656  -22.57041 1.000 13.60621 ? 4   ARG B CD  1 
ATOM   2299 N NE  . ARG B 1 2   ? -4.17978  -0.35278  -23.96088 1.000 13.14950 ? 4   ARG B NE  1 
ATOM   2300 C CZ  . ARG B 1 2   ? -3.17510  0.13941   -24.69731 1.000 18.59360 ? 4   ARG B CZ  1 
ATOM   2301 N NH1 . ARG B 1 2   ? -1.93712  0.25645   -24.19576 1.000 21.52777 ? 4   ARG B NH1 1 
ATOM   2302 N NH2 . ARG B 1 2   ? -3.39958  0.51430   -25.95108 1.000 12.58562 ? 4   ARG B NH2 1 
ATOM   2303 N N   . LYS B 1 3   ? -1.96872  -3.06258  -18.77434 1.000 16.10413 ? 5   LYS B N   1 
ATOM   2304 C CA  . LYS B 1 3   ? -1.62322  -2.75384  -17.39517 1.000 15.89757 ? 5   LYS B CA  1 
ATOM   2305 C C   . LYS B 1 3   ? -2.62308  -1.72761  -16.88497 1.000 15.36556 ? 5   LYS B C   1 
ATOM   2306 O O   . LYS B 1 3   ? -2.68342  -0.60918  -17.40691 1.000 15.32688 ? 5   LYS B O   1 
ATOM   2307 C CB  . LYS B 1 3   ? -0.19846  -2.21683  -17.32715 1.000 13.77603 ? 5   LYS B CB  1 
ATOM   2308 C CG  . LYS B 1 3   ? 0.35815   -2.08653  -15.93838 1.000 13.90898 ? 5   LYS B CG  1 
ATOM   2309 C CD  . LYS B 1 3   ? 1.75230   -2.69494  -15.85306 1.000 28.22641 ? 5   LYS B CD  1 
ATOM   2310 C CE  . LYS B 1 3   ? 1.71960   -4.19286  -16.08852 1.000 25.77635 ? 5   LYS B CE  1 
ATOM   2311 N NZ  . LYS B 1 3   ? 3.10119   -4.74863  -16.02719 1.000 29.59801 ? 5   LYS B NZ  1 
ATOM   2312 N N   . MET B 1 4   ? -3.45146  -2.08895  -15.91041 1.000 11.63758 ? 6   MET B N   1 
ATOM   2313 C CA  . MET B 1 4   ? -4.44012  -1.11905  -15.45941 1.000 9.86377  ? 6   MET B CA  1 
ATOM   2314 C C   . MET B 1 4   ? -4.38071  -0.92276  -13.95044 1.000 7.63508  ? 6   MET B C   1 
ATOM   2315 O O   . MET B 1 4   ? -4.25599  -1.88307  -13.18269 1.000 10.44087 ? 6   MET B O   1 
ATOM   2316 C CB  . MET B 1 4   ? -5.85925  -1.48147  -15.94404 1.000 14.13315 ? 6   MET B CB  1 
ATOM   2317 C CG  . MET B 1 4   ? -6.51917  -2.72377  -15.42601 1.000 15.08611 ? 6   MET B CG  1 
ATOM   2318 S SD  . MET B 1 4   ? -8.25820  -2.75402  -16.02366 1.000 26.59115 ? 6   MET B SD  1 
ATOM   2319 C CE  . MET B 1 4   ? -8.04937  -2.57333  -17.77734 1.000 15.67196 ? 6   MET B CE  1 
ATOM   2320 N N   . ALA B 1 5   ? -4.43803  0.33892   -13.54442 1.000 5.40064  ? 7   ALA B N   1 
ATOM   2321 C CA  . ALA B 1 5   ? -4.37313  0.75028   -12.15771 1.000 4.95765  ? 7   ALA B CA  1 
ATOM   2322 C C   . ALA B 1 5   ? -5.77700  0.87755   -11.60155 1.000 7.56412  ? 7   ALA B C   1 
ATOM   2323 O O   . ALA B 1 5   ? -6.75659  0.90432   -12.35361 1.000 6.66191  ? 7   ALA B O   1 
ATOM   2324 C CB  . ALA B 1 5   ? -3.62327  2.07495   -12.03628 1.000 6.30453  ? 7   ALA B CB  1 
ATOM   2325 N N   . PHE B 1 6   ? -5.87126  0.93473   -10.26878 1.000 2.65497  ? 8   PHE B N   1 
ATOM   2326 C CA  . PHE B 1 6   ? -7.15629  1.18775   -9.63160  1.000 4.75176  ? 8   PHE B CA  1 
ATOM   2327 C C   . PHE B 1 6   ? -7.58136  2.63275   -9.88124  1.000 6.99748  ? 8   PHE B C   1 
ATOM   2328 O O   . PHE B 1 6   ? -6.73520  3.51161   -10.07009 1.000 4.83650  ? 8   PHE B O   1 
ATOM   2329 C CB  . PHE B 1 6   ? -7.10121  0.92636   -8.12401  1.000 3.65849  ? 8   PHE B CB  1 
ATOM   2330 C CG  . PHE B 1 6   ? -7.05601  -0.52973  -7.75871  1.000 4.66233  ? 8   PHE B CG  1 
ATOM   2331 C CD1 . PHE B 1 6   ? -8.21233  -1.28759  -7.72070  1.000 10.28094 ? 8   PHE B CD1 1 
ATOM   2332 C CD2 . PHE B 1 6   ? -5.85006  -1.14142  -7.44456  1.000 8.19685  ? 8   PHE B CD2 1 
ATOM   2333 C CE1 . PHE B 1 6   ? -8.17437  -2.63745  -7.38358  1.000 9.25748  ? 8   PHE B CE1 1 
ATOM   2334 C CE2 . PHE B 1 6   ? -5.80163  -2.49412  -7.10718  1.000 9.65821  ? 8   PHE B CE2 1 
ATOM   2335 C CZ  . PHE B 1 6   ? -6.96901  -3.23869  -7.07307  1.000 9.18614  ? 8   PHE B CZ  1 
ATOM   2336 N N   . PRO B 1 7   ? -8.88991  2.90648   -9.90688  1.000 9.27155  ? 9   PRO B N   1 
ATOM   2337 C CA  . PRO B 1 7   ? -9.32532  4.30722   -9.92121  1.000 7.26621  ? 9   PRO B CA  1 
ATOM   2338 C C   . PRO B 1 7   ? -8.76665  4.98788   -8.68438  1.000 6.34462  ? 9   PRO B C   1 
ATOM   2339 O O   . PRO B 1 7   ? -8.76055  4.40822   -7.59682  1.000 10.54953 ? 9   PRO B O   1 
ATOM   2340 C CB  . PRO B 1 7   ? -10.86047 4.22026   -9.89023  1.000 5.44644  ? 9   PRO B CB  1 
ATOM   2341 C CG  . PRO B 1 7   ? -11.20455 2.78142   -10.13601 1.000 4.95858  ? 9   PRO B CG  1 
ATOM   2342 C CD  . PRO B 1 7   ? -10.01201 1.97717   -9.69501  1.000 4.18797  ? 9   PRO B CD  1 
ATOM   2343 N N   . SER B 1 8   ? -8.27569  6.21239   -8.85969  1.000 4.86407  ? 10  SER B N   1 
ATOM   2344 C CA  . SER B 1 8   ? -7.45647  6.86172   -7.84809  1.000 6.66141  ? 10  SER B CA  1 
ATOM   2345 C C   . SER B 1 8   ? -8.19549  7.91622   -7.02846  1.000 5.52897  ? 10  SER B C   1 
ATOM   2346 O O   . SER B 1 8   ? -7.56775  8.56768   -6.18825  1.000 6.68004  ? 10  SER B O   1 
ATOM   2347 C CB  . SER B 1 8   ? -6.23350  7.50509   -8.50810  1.000 5.81559  ? 10  SER B CB  1 
ATOM   2348 O OG  . SER B 1 8   ? -6.61936  8.44093   -9.49625  1.000 6.74191  ? 10  SER B OG  1 
ATOM   2349 N N   . GLY B 1 9   ? -9.50471  8.09042   -7.23274  1.000 4.75980  ? 11  GLY B N   1 
ATOM   2350 C CA  . GLY B 1 9   ? -10.19554 9.21246   -6.61774  1.000 5.62941  ? 11  GLY B CA  1 
ATOM   2351 C C   . GLY B 1 9   ? -10.14911 9.19575   -5.09805  1.000 7.12935  ? 11  GLY B C   1 
ATOM   2352 O O   . GLY B 1 9   ? -9.95600  10.23580  -4.46408  1.000 6.67794  ? 11  GLY B O   1 
ATOM   2353 N N   . LYS B 1 10  ? -10.32103 8.01872   -4.49074  1.000 5.44594  ? 12  LYS B N   1 
ATOM   2354 C CA  . LYS B 1 10  ? -10.35390 7.96155   -3.03165  1.000 5.85517  ? 12  LYS B CA  1 
ATOM   2355 C C   . LYS B 1 10  ? -9.02298  8.39725   -2.42923  1.000 8.89754  ? 12  LYS B C   1 
ATOM   2356 O O   . LYS B 1 10  ? -8.98126  8.88939   -1.29554  1.000 6.83709  ? 12  LYS B O   1 
ATOM   2357 C CB  . LYS B 1 10  ? -10.71744 6.54862   -2.57322  1.000 8.98624  ? 12  LYS B CB  1 
ATOM   2358 C CG  . LYS B 1 10  ? -12.17356 6.18248   -2.83232  1.000 8.78299  ? 12  LYS B CG  1 
ATOM   2359 C CD  . LYS B 1 10  ? -12.47664 4.75113   -2.42046  1.000 14.70552 ? 12  LYS B CD  1 
ATOM   2360 C CE  . LYS B 1 10  ? -13.98951 4.52958   -2.20022  1.000 19.95346 ? 12  LYS B CE  1 
ATOM   2361 N NZ  . LYS B 1 10  ? -14.73738 4.68709   -3.48759  1.000 18.43337 ? 12  LYS B NZ  1 
ATOM   2362 N N   . VAL B 1 11  ? -7.93406  8.22051   -3.17193  1.000 4.51562  ? 13  VAL B N   1 
ATOM   2363 C CA  . VAL B 1 11  ? -6.60605  8.60593   -2.71529  1.000 5.16170  ? 13  VAL B CA  1 
ATOM   2364 C C   . VAL B 1 11  ? -6.27278  10.05042  -3.09734  1.000 6.44470  ? 13  VAL B C   1 
ATOM   2365 O O   . VAL B 1 11  ? -5.63634  10.76519  -2.31766  1.000 8.03132  ? 13  VAL B O   1 
ATOM   2366 C CB  . VAL B 1 11  ? -5.57365  7.59969   -3.27923  1.000 3.54170  ? 13  VAL B CB  1 
ATOM   2367 C CG1 . VAL B 1 11  ? -4.13835  8.05735   -3.03114  1.000 3.83558  ? 13  VAL B CG1 1 
ATOM   2368 C CG2 . VAL B 1 11  ? -5.80936  6.20943   -2.68397  1.000 2.79805  ? 13  VAL B CG2 1 
ATOM   2369 N N   . GLU B 1 12  ? -6.68137  10.51549  -4.28839  1.000 4.95512  ? 14  GLU B N   1 
ATOM   2370 C CA  . GLU B 1 12  ? -6.41823  11.90324  -4.67888  1.000 4.50789  ? 14  GLU B CA  1 
ATOM   2371 C C   . GLU B 1 12  ? -6.85293  12.88150  -3.59527  1.000 5.99841  ? 14  GLU B C   1 
ATOM   2372 O O   . GLU B 1 12  ? -6.20224  13.91299  -3.37571  1.000 6.96386  ? 14  GLU B O   1 
ATOM   2373 C CB  . GLU B 1 12  ? -7.14589  12.25504  -5.98648  1.000 7.32449  ? 14  GLU B CB  1 
ATOM   2374 C CG  . GLU B 1 12  ? -6.62080  11.58456  -7.24520  1.000 5.05115  ? 14  GLU B CG  1 
ATOM   2375 C CD  . GLU B 1 12  ? -7.59725  11.71377  -8.42393  1.000 6.74989  ? 14  GLU B CD  1 
ATOM   2376 O OE1 . GLU B 1 12  ? -7.98833  12.86363  -8.76017  1.000 5.71454  ? 14  GLU B OE1 1 
ATOM   2377 O OE2 . GLU B 1 12  ? -7.96694  10.66006  -9.01299  1.000 3.55539  ? 14  GLU B OE2 1 
ATOM   2378 N N   . GLY B 1 13  ? -7.96000  12.57238  -2.91540  1.000 6.48313  ? 15  GLY B N   1 
ATOM   2379 C CA  . GLY B 1 13  ? -8.52161  13.38175  -1.85456  1.000 7.24891  ? 15  GLY B CA  1 
ATOM   2380 C C   . GLY B 1 13  ? -7.67520  13.47928  -0.60271  1.000 7.76881  ? 15  GLY B C   1 
ATOM   2381 O O   . GLY B 1 13  ? -7.98665  14.30804  0.25621   1.000 10.45015 ? 15  GLY B O   1 
ATOM   2382 N N   . CYS B 1 14  ? -6.61908  12.67749  -0.48245  1.000 4.71052  ? 16  CYS B N   1 
ATOM   2383 C CA  . CYS B 1 14  ? -5.79504  12.63767  0.72277   1.000 8.11007  ? 16  CYS B CA  1 
ATOM   2384 C C   . CYS B 1 14  ? -4.43163  13.29336  0.55631   1.000 5.71050  ? 16  CYS B C   1 
ATOM   2385 O O   . CYS B 1 14  ? -3.66568  13.34000  1.52667   1.000 8.43640  ? 16  CYS B O   1 
ATOM   2386 C CB  . CYS B 1 14  ? -5.58584  11.18694  1.17990   1.000 5.21406  ? 16  CYS B CB  1 
ATOM   2387 S SG  . CYS B 1 14  ? -7.08569  10.24563  1.41790   1.000 9.31481  ? 16  CYS B SG  1 
ATOM   2388 N N   . MET B 1 15  ? -4.10809  13.79964  -0.62916  1.000 7.91405  ? 17  MET B N   1 
ATOM   2389 C CA  . MET B 1 15  ? -2.77073  14.29277  -0.92699  1.000 6.81002  ? 17  MET B CA  1 
ATOM   2390 C C   . MET B 1 15  ? -2.64090  15.75167  -0.52477  1.000 9.38625  ? 17  MET B C   1 
ATOM   2391 O O   . MET B 1 15  ? -3.45950  16.58466  -0.92404  1.000 7.43063  ? 17  MET B O   1 
ATOM   2392 C CB  . MET B 1 15  ? -2.45488  14.15221  -2.41533  1.000 8.48713  ? 17  MET B CB  1 
ATOM   2393 C CG  . MET B 1 15  ? -2.34580  12.73372  -2.92350  1.000 9.75445  ? 17  MET B CG  1 
ATOM   2394 S SD  . MET B 1 15  ? -1.45103  11.60090  -1.84907  1.000 10.15471 ? 17  MET B SD  1 
ATOM   2395 C CE  . MET B 1 15  ? -2.84470  10.74476  -1.23876  1.000 14.87237 ? 17  MET B CE  1 
ATOM   2396 N N   . VAL B 1 16  ? -1.59242  16.06091  0.23845   1.000 7.12547  ? 18  VAL B N   1 
ATOM   2397 C CA  . VAL B 1 16  ? -1.27871  17.42634  0.63501   1.000 8.78425  ? 18  VAL B CA  1 
ATOM   2398 C C   . VAL B 1 16  ? 0.19712   17.71410  0.36466   1.000 10.04676 ? 18  VAL B C   1 
ATOM   2399 O O   . VAL B 1 16  ? 1.00405   16.80858  0.13939   1.000 6.66883  ? 18  VAL B O   1 
ATOM   2400 C CB  . VAL B 1 16  ? -1.61354  17.68292  2.11827   1.000 11.14449 ? 18  VAL B CB  1 
ATOM   2401 C CG1 . VAL B 1 16  ? -3.10222  17.54879  2.34227   1.000 7.60557  ? 18  VAL B CG1 1 
ATOM   2402 C CG2 . VAL B 1 16  ? -0.87523  16.70076  2.99616   1.000 9.13805  ? 18  VAL B CG2 1 
ATOM   2403 N N   . GLN B 1 17  ? 0.53272   19.00573  0.37825   1.000 11.03455 ? 19  GLN B N   1 
ATOM   2404 C CA  . GLN B 1 17  ? 1.90840   19.47967  0.31220   1.000 12.27504 ? 19  GLN B CA  1 
ATOM   2405 C C   . GLN B 1 17  ? 2.44537   19.71475  1.71596   1.000 15.43016 ? 19  GLN B C   1 
ATOM   2406 O O   . GLN B 1 17  ? 1.72646   20.22151  2.58414   1.000 16.19231 ? 19  GLN B O   1 
ATOM   2407 C CB  . GLN B 1 17  ? 2.00025   20.78046  -0.48743  1.000 13.49987 ? 19  GLN B CB  1 
ATOM   2408 C CG  . GLN B 1 17  ? 3.42282   21.28520  -0.66626  1.000 16.42244 ? 19  GLN B CG  1 
ATOM   2409 C CD  . GLN B 1 17  ? 3.50361   22.51899  -1.55110  1.000 22.79381 ? 19  GLN B CD  1 
ATOM   2410 O OE1 . GLN B 1 17  ? 4.45706   22.69188  -2.31155  1.000 27.39738 ? 19  GLN B OE1 1 
ATOM   2411 N NE2 . GLN B 1 17  ? 2.50924   23.38647  -1.44786  1.000 24.75926 ? 19  GLN B NE2 1 
ATOM   2412 N N   . VAL B 1 18  ? 3.71303   19.34437  1.93230   1.000 14.08542 ? 20  VAL B N   1 
ATOM   2413 C CA  . VAL B 1 18  ? 4.38673   19.51378  3.22321   1.000 16.71125 ? 20  VAL B CA  1 
ATOM   2414 C C   . VAL B 1 18  ? 5.73358   20.18871  2.99353   1.000 18.33722 ? 20  VAL B C   1 
ATOM   2415 O O   . VAL B 1 18  ? 6.57462   19.68111  2.23894   1.000 16.91344 ? 20  VAL B O   1 
ATOM   2416 C CB  . VAL B 1 18  ? 4.58316   18.18419  3.97098   1.000 11.62271 ? 20  VAL B CB  1 
ATOM   2417 C CG1 . VAL B 1 18  ? 5.33067   18.41815  5.27431   1.000 16.06437 ? 20  VAL B CG1 1 
ATOM   2418 C CG2 . VAL B 1 18  ? 3.25722   17.53178  4.25437   1.000 7.64127  ? 20  VAL B CG2 1 
ATOM   2419 N N   . THR B 1 19  ? 5.94480   21.31668  3.66072   1.000 22.65943 ? 21  THR B N   1 
ATOM   2420 C CA  . THR B 1 19  ? 7.17529   22.08426  3.55288   1.000 23.28702 ? 21  THR B CA  1 
ATOM   2421 C C   . THR B 1 19  ? 7.79152   22.21432  4.93206   1.000 22.95700 ? 21  THR B C   1 
ATOM   2422 O O   . THR B 1 19  ? 7.10429   22.57923  5.89266   1.000 22.26281 ? 21  THR B O   1 
ATOM   2423 C CB  . THR B 1 19  ? 6.91303   23.46784  2.96154   1.000 24.57289 ? 21  THR B CB  1 
ATOM   2424 O OG1 . THR B 1 19  ? 6.24112   23.32252  1.70387   1.000 23.23404 ? 21  THR B OG1 1 
ATOM   2425 C CG2 . THR B 1 19  ? 8.21012   24.22061  2.76008   1.000 23.72347 ? 21  THR B CG2 1 
ATOM   2426 N N   . CYS B 1 20  ? 9.07528   21.88922  5.03332   1.000 21.33866 ? 22  CYS B N   1 
ATOM   2427 C CA  . CYS B 1 20  ? 9.83559   22.09913  6.26269   1.000 25.09437 ? 22  CYS B CA  1 
ATOM   2428 C C   . CYS B 1 20  ? 11.10944  22.83247  5.86773   1.000 28.44561 ? 22  CYS B C   1 
ATOM   2429 O O   . CYS B 1 20  ? 12.03334  22.23105  5.31077   1.000 28.11777 ? 22  CYS B O   1 
ATOM   2430 C CB  . CYS B 1 20  ? 10.14079  20.79062  6.97472   1.000 23.37127 ? 22  CYS B CB  1 
ATOM   2431 S SG  . CYS B 1 20  ? 11.10790  21.01724  8.46036   1.000 23.20932 ? 22  CYS B SG  1 
ATOM   2432 N N   . GLY B 1 21  ? 11.14529  24.13002  6.15235   1.000 27.03617 ? 23  GLY B N   1 
ATOM   2433 C CA  . GLY B 1 21  ? 12.24716  24.96350  5.73266   1.000 25.54941 ? 23  GLY B CA  1 
ATOM   2434 C C   . GLY B 1 21  ? 12.23285  25.18434  4.23750   1.000 27.04406 ? 23  GLY B C   1 
ATOM   2435 O O   . GLY B 1 21  ? 11.27913  25.74769  3.68799   1.000 32.71844 ? 23  GLY B O   1 
ATOM   2436 N N   . THR B 1 22  ? 13.28456  24.72911  3.56627   1.000 25.92597 ? 24  THR B N   1 
ATOM   2437 C CA  . THR B 1 22  ? 13.39696  24.87298  2.12441   1.000 32.29031 ? 24  THR B CA  1 
ATOM   2438 C C   . THR B 1 22  ? 12.93300  23.63641  1.35902   1.000 29.60193 ? 24  THR B C   1 
ATOM   2439 O O   . THR B 1 22  ? 12.89196  23.67191  0.12765   1.000 28.04574 ? 24  THR B O   1 
ATOM   2440 C CB  . THR B 1 22  ? 14.84433  25.19992  1.75007   1.000 28.00306 ? 24  THR B CB  1 
ATOM   2441 O OG1 . THR B 1 22  ? 14.88602  25.67917  0.40388   1.000 42.67664 ? 24  THR B OG1 1 
ATOM   2442 C CG2 . THR B 1 22  ? 15.71920  23.96004  1.86982   1.000 23.52550 ? 24  THR B CG2 1 
ATOM   2443 N N   . THR B 1 23  ? 12.57632  22.55323  2.04738   1.000 26.24519 ? 25  THR B N   1 
ATOM   2444 C CA  . THR B 1 23  ? 12.23684  21.28868  1.40531   1.000 24.52887 ? 25  THR B CA  1 
ATOM   2445 C C   . THR B 1 23  ? 10.72459  21.11773  1.31580   1.000 23.78876 ? 25  THR B C   1 
ATOM   2446 O O   . THR B 1 23  ? 10.00041  21.39279  2.27630   1.000 27.69832 ? 25  THR B O   1 
ATOM   2447 C CB  . THR B 1 23  ? 12.85113  20.11267  2.17197   1.000 24.60792 ? 25  THR B CB  1 
ATOM   2448 O OG1 . THR B 1 23  ? 14.27484  20.19676  2.09123   1.000 30.21706 ? 25  THR B OG1 1 
ATOM   2449 C CG2 . THR B 1 23  ? 12.41645  18.77823  1.57474   1.000 22.08575 ? 25  THR B CG2 1 
ATOM   2450 N N   . THR B 1 24  ? 10.25660  20.65213  0.15632   1.000 24.39088 ? 26  THR B N   1 
ATOM   2451 C CA  . THR B 1 24  ? 8.85047   20.37236  -0.08425  1.000 20.38753 ? 26  THR B CA  1 
ATOM   2452 C C   . THR B 1 24  ? 8.68487   18.98444  -0.68630  1.000 20.12812 ? 26  THR B C   1 
ATOM   2453 O O   . THR B 1 24  ? 9.45894   18.58089  -1.56302  1.000 19.41081 ? 26  THR B O   1 
ATOM   2454 C CB  . THR B 1 24  ? 8.22908   21.42637  -1.01455  1.000 25.66204 ? 26  THR B CB  1 
ATOM   2455 O OG1 . THR B 1 24  ? 7.91952   22.60562  -0.26128  1.000 30.97543 ? 26  THR B OG1 1 
ATOM   2456 C CG2 . THR B 1 24  ? 6.96025   20.90455  -1.67639  1.000 19.96461 ? 26  THR B CG2 1 
ATOM   2457 N N   . LEU B 1 25  ? 7.67219   18.26136  -0.20632  1.000 15.20355 ? 27  LEU B N   1 
ATOM   2458 C CA  . LEU B 1 25  ? 7.26917   16.98126  -0.77573  1.000 10.13889 ? 27  LEU B CA  1 
ATOM   2459 C C   . LEU B 1 25  ? 5.78739   16.76165  -0.44956  1.000 10.13279 ? 27  LEU B C   1 
ATOM   2460 O O   . LEU B 1 25  ? 5.08167   17.68265  -0.02756  1.000 11.15458 ? 27  LEU B O   1 
ATOM   2461 C CB  . LEU B 1 25  ? 8.19192   15.85593  -0.27260  1.000 8.63428  ? 27  LEU B CB  1 
ATOM   2462 C CG  . LEU B 1 25  ? 8.61840   15.81259  1.20558   1.000 14.40512 ? 27  LEU B CG  1 
ATOM   2463 C CD1 . LEU B 1 25  ? 7.39750   15.54454  2.12051   1.000 7.44600  ? 27  LEU B CD1 1 
ATOM   2464 C CD2 . LEU B 1 25  ? 9.72731   14.76727  1.43835   1.000 5.50272  ? 27  LEU B CD2 1 
ATOM   2465 N N   . ASN B 1 26  ? 5.31619   15.53208  -0.62416  1.000 7.99191  ? 28  ASN B N   1 
ATOM   2466 C CA  . ASN B 1 26  ? 3.90550   15.20944  -0.47180  1.000 8.33726  ? 28  ASN B CA  1 
ATOM   2467 C C   . ASN B 1 26  ? 3.63914   14.50238  0.85489   1.000 7.66791  ? 28  ASN B C   1 
ATOM   2468 O O   . ASN B 1 26  ? 4.52511   13.85857  1.42833   1.000 8.08428  ? 28  ASN B O   1 
ATOM   2469 C CB  . ASN B 1 26  ? 3.43876   14.34199  -1.64939  1.000 8.31492  ? 28  ASN B CB  1 
ATOM   2470 C CG  . ASN B 1 26  ? 3.86574   14.91900  -2.99591  1.000 8.36300  ? 28  ASN B CG  1 
ATOM   2471 O OD1 . ASN B 1 26  ? 3.27913   15.88560  -3.47291  1.000 7.31992  ? 28  ASN B OD1 1 
ATOM   2472 N ND2 . ASN B 1 26  ? 4.91203   14.34679  -3.59488  1.000 9.05312  ? 28  ASN B ND2 1 
ATOM   2473 N N   . GLY B 1 27  ? 2.40672   14.64558  1.34861   1.000 4.72310  ? 29  GLY B N   1 
ATOM   2474 C CA  . GLY B 1 27  ? 1.96861   13.91389  2.51494   1.000 4.81333  ? 29  GLY B CA  1 
ATOM   2475 C C   . GLY B 1 27  ? 0.60268   13.28461  2.29947   1.000 8.55069  ? 29  GLY B C   1 
ATOM   2476 O O   . GLY B 1 27  ? -0.16634  13.69207  1.42339   1.000 7.70239  ? 29  GLY B O   1 
ATOM   2477 N N   . LEU B 1 28  ? 0.31410   12.26936  3.12267   1.000 3.61891  ? 30  LEU B N   1 
ATOM   2478 C CA  . LEU B 1 28  ? -0.96714  11.56904  3.12069   1.000 5.85123  ? 30  LEU B CA  1 
ATOM   2479 C C   . LEU B 1 28  ? -1.79318  12.03326  4.32114   1.000 8.33695  ? 30  LEU B C   1 
ATOM   2480 O O   . LEU B 1 28  ? -1.37875  11.84353  5.47326   1.000 6.05930  ? 30  LEU B O   1 
ATOM   2481 C CB  . LEU B 1 28  ? -0.75996  10.04924  3.16645   1.000 5.28285  ? 30  LEU B CB  1 
ATOM   2482 C CG  . LEU B 1 28  ? -1.99740  9.15248   2.96473   1.000 3.38581  ? 30  LEU B CG  1 
ATOM   2483 C CD1 . LEU B 1 28  ? -2.54588  9.26946   1.57735   1.000 2.66985  ? 30  LEU B CD1 1 
ATOM   2484 C CD2 . LEU B 1 28  ? -1.73998  7.68566   3.25796   1.000 3.55345  ? 30  LEU B CD2 1 
ATOM   2485 N N   . TRP B 1 29  ? -2.96303  12.62987  4.05295   1.000 7.58666  ? 31  TRP B N   1 
ATOM   2486 C CA  . TRP B 1 29  ? -3.80885  13.22907  5.08848   1.000 6.58741  ? 31  TRP B CA  1 
ATOM   2487 C C   . TRP B 1 29  ? -5.01038  12.31902  5.35300   1.000 9.65821  ? 31  TRP B C   1 
ATOM   2488 O O   . TRP B 1 29  ? -5.92978  12.23608  4.53422   1.000 8.89386  ? 31  TRP B O   1 
ATOM   2489 C CB  . TRP B 1 29  ? -4.25433  14.62778  4.65978   1.000 10.41811 ? 31  TRP B CB  1 
ATOM   2490 C CG  . TRP B 1 29  ? -5.16281  15.36783  5.63472   1.000 12.09686 ? 31  TRP B CG  1 
ATOM   2491 C CD1 . TRP B 1 29  ? -5.26678  15.17049  6.98100   1.000 11.57038 ? 31  TRP B CD1 1 
ATOM   2492 C CD2 . TRP B 1 29  ? -6.08626  16.41672  5.31434   1.000 11.17256 ? 31  TRP B CD2 1 
ATOM   2493 N NE1 . TRP B 1 29  ? -6.19031  16.03498  7.51990   1.000 11.97445 ? 31  TRP B NE1 1 
ATOM   2494 C CE2 . TRP B 1 29  ? -6.70546  16.81150  6.51711   1.000 12.28614 ? 31  TRP B CE2 1 
ATOM   2495 C CE3 . TRP B 1 29  ? -6.44316  17.06405  4.12705   1.000 10.73183 ? 31  TRP B CE3 1 
ATOM   2496 C CZ2 . TRP B 1 29  ? -7.66706  17.82102  6.56717   1.000 17.95162 ? 31  TRP B CZ2 1 
ATOM   2497 C CZ3 . TRP B 1 29  ? -7.39806  18.06517  4.17401   1.000 13.37327 ? 31  TRP B CZ3 1 
ATOM   2498 C CH2 . TRP B 1 29  ? -8.00112  18.43512  5.38745   1.000 15.27824 ? 31  TRP B CH2 1 
ATOM   2499 N N   . LEU B 1 30  ? -4.99921  11.64129  6.49712   1.000 9.34695  ? 32  LEU B N   1 
ATOM   2500 C CA  . LEU B 1 30  ? -6.03971  10.70181  6.88331   1.000 8.72951  ? 32  LEU B CA  1 
ATOM   2501 C C   . LEU B 1 30  ? -6.50850  11.05147  8.28994   1.000 13.40421 ? 32  LEU B C   1 
ATOM   2502 O O   . LEU B 1 30  ? -5.68756  11.15963  9.20985   1.000 7.86029  ? 32  LEU B O   1 
ATOM   2503 C CB  . LEU B 1 30  ? -5.53160  9.26246   6.83363   1.000 7.92848  ? 32  LEU B CB  1 
ATOM   2504 C CG  . LEU B 1 30  ? -5.03464  8.73571   5.48543   1.000 8.23633  ? 32  LEU B CG  1 
ATOM   2505 C CD1 . LEU B 1 30  ? -4.32150  7.40494   5.65584   1.000 3.56209  ? 32  LEU B CD1 1 
ATOM   2506 C CD2 . LEU B 1 30  ? -6.20910  8.60641   4.52599   1.000 8.68162  ? 32  LEU B CD2 1 
ATOM   2507 N N   . ASP B 1 31  ? -7.82632  11.21685  8.45529   1.000 14.30903 ? 33  ASP B N   1 
ATOM   2508 C CA  . ASP B 1 31  ? -8.41301  11.78962  9.68093   1.000 13.00843 ? 33  ASP B CA  1 
ATOM   2509 C C   . ASP B 1 31  ? -7.63163  13.07162  9.97112   1.000 12.08490 ? 33  ASP B C   1 
ATOM   2510 O O   . ASP B 1 31  ? -7.48532  13.91347  9.07608   1.000 12.56598 ? 33  ASP B O   1 
ATOM   2511 C CB  . ASP B 1 31  ? -8.41749  10.75797  10.80458  1.000 15.29090 ? 33  ASP B CB  1 
ATOM   2512 C CG  . ASP B 1 31  ? -9.06702  9.44675   10.40049  1.000 16.73641 ? 33  ASP B CG  1 
ATOM   2513 O OD1 . ASP B 1 31  ? -10.24493 9.47153   9.97568   1.000 15.78085 ? 33  ASP B OD1 1 
ATOM   2514 O OD2 . ASP B 1 31  ? -8.39396  8.39266   10.51518  1.000 20.93226 ? 33  ASP B OD2 1 
ATOM   2515 N N   . ASP B 1 32  ? -7.06510  13.24555  11.15914  1.000 12.00368 ? 34  ASP B N   1 
ATOM   2516 C CA  . ASP B 1 32  ? -6.34487  14.47159  11.47561  1.000 11.35660 ? 34  ASP B CA  1 
ATOM   2517 C C   . ASP B 1 32  ? -4.83697  14.24373  11.61959  1.000 10.14730 ? 34  ASP B C   1 
ATOM   2518 O O   . ASP B 1 32  ? -4.18826  14.84470  12.47319  1.000 13.77599 ? 34  ASP B O   1 
ATOM   2519 C CB  . ASP B 1 32  ? -6.92810  15.13630  12.72277  1.000 13.29475 ? 34  ASP B CB  1 
ATOM   2520 C CG  . ASP B 1 32  ? -6.80000  14.27714  13.98414  1.000 23.36081 ? 34  ASP B CG  1 
ATOM   2521 O OD1 . ASP B 1 32  ? -6.34579  13.11580  13.90791  1.000 21.40884 ? 34  ASP B OD1 1 
ATOM   2522 O OD2 . ASP B 1 32  ? -7.15103  14.78015  15.07200  1.000 24.26274 ? 34  ASP B OD2 1 
ATOM   2523 N N   . VAL B 1 33  ? -4.25467  13.39831  10.76985  1.000 9.80472  ? 35  VAL B N   1 
ATOM   2524 C CA  . VAL B 1 33  ? -2.80763  13.19109  10.72290  1.000 9.10904  ? 35  VAL B CA  1 
ATOM   2525 C C   . VAL B 1 33  ? -2.33677  13.25843  9.27608   1.000 10.26984 ? 35  VAL B C   1 
ATOM   2526 O O   . VAL B 1 33  ? -2.97595  12.69822  8.37774   1.000 7.94168  ? 35  VAL B O   1 
ATOM   2527 C CB  . VAL B 1 33  ? -2.39508  11.83982  11.34170  1.000 10.77073 ? 35  VAL B CB  1 
ATOM   2528 C CG1 . VAL B 1 33  ? -0.86627  11.61718  11.20600  1.000 9.55136  ? 35  VAL B CG1 1 
ATOM   2529 C CG2 . VAL B 1 33  ? -2.83975  11.75980  12.79043  1.000 12.73007 ? 35  VAL B CG2 1 
ATOM   2530 N N   . VAL B 1 34  ? -1.21175  13.94051  9.05424   1.000 9.25250  ? 36  VAL B N   1 
ATOM   2531 C CA  . VAL B 1 34  ? -0.50630  13.92171  7.77671   1.000 10.56550 ? 36  VAL B CA  1 
ATOM   2532 C C   . VAL B 1 34  ? 0.70998   13.02036  7.92427   1.000 6.98741  ? 36  VAL B C   1 
ATOM   2533 O O   . VAL B 1 34  ? 1.45822   13.15189  8.89782   1.000 8.48989  ? 36  VAL B O   1 
ATOM   2534 C CB  . VAL B 1 34  ? -0.09312  15.33988  7.34933   1.000 11.03910 ? 36  VAL B CB  1 
ATOM   2535 C CG1 . VAL B 1 34  ? 0.67180   15.30273  6.03745   1.000 7.48004  ? 36  VAL B CG1 1 
ATOM   2536 C CG2 . VAL B 1 34  ? -1.32616  16.24189  7.24189   1.000 8.55117  ? 36  VAL B CG2 1 
ATOM   2537 N N   . TYR B 1 35  ? 0.90434   12.10666  6.96301   1.000 6.72178  ? 37  TYR B N   1 
ATOM   2538 C CA  . TYR B 1 35  ? 2.01875   11.16098  6.91626   1.000 5.28709  ? 37  TYR B CA  1 
ATOM   2539 C C   . TYR B 1 35  ? 2.96141   11.53123  5.77649   1.000 6.27662  ? 37  TYR B C   1 
ATOM   2540 O O   . TYR B 1 35  ? 2.50817   11.81632  4.66560   1.000 6.19025  ? 37  TYR B O   1 
ATOM   2541 C CB  . TYR B 1 35  ? 1.52234   9.72276   6.69393   1.000 4.39493  ? 37  TYR B CB  1 
ATOM   2542 C CG  . TYR B 1 35  ? 0.57367   9.20865   7.75270   1.000 9.24518  ? 37  TYR B CG  1 
ATOM   2543 C CD1 . TYR B 1 35  ? -0.76777  9.58758   7.75600   1.000 7.29681  ? 37  TYR B CD1 1 
ATOM   2544 C CD2 . TYR B 1 35  ? 1.02084   8.34722   8.76425   1.000 7.87808  ? 37  TYR B CD2 1 
ATOM   2545 C CE1 . TYR B 1 35  ? -1.64192  9.12681   8.74587   1.000 6.81334  ? 37  TYR B CE1 1 
ATOM   2546 C CE2 . TYR B 1 35  ? 0.15114   7.87606   9.75695   1.000 9.08984  ? 37  TYR B CE2 1 
ATOM   2547 C CZ  . TYR B 1 35  ? -1.17521  8.27125   9.73847   1.000 11.28897 ? 37  TYR B CZ  1 
ATOM   2548 O OH  . TYR B 1 35  ? -2.04564  7.81969   10.70732  1.000 15.27129 ? 37  TYR B OH  1 
ATOM   2549 N N   . CYS B 1 36  ? 4.26878   11.49157  6.02843   1.000 6.17060  ? 38  CYS B N   1 
ATOM   2550 C CA  . CYS B 1 36  ? 5.24402   11.82632  4.99538   1.000 5.60117  ? 38  CYS B CA  1 
ATOM   2551 C C   . CYS B 1 36  ? 6.61016   11.27339  5.41455   1.000 6.13002  ? 38  CYS B C   1 
ATOM   2552 O O   . CYS B 1 36  ? 6.80061   10.86363  6.57007   1.000 7.87024  ? 38  CYS B O   1 
ATOM   2553 C CB  . CYS B 1 36  ? 5.28742   13.34877  4.75050   1.000 6.84479  ? 38  CYS B CB  1 
ATOM   2554 S SG  . CYS B 1 36  ? 6.22361   14.32431  5.96644   1.000 11.80826 ? 38  CYS B SG  1 
ATOM   2555 N N   . PRO B 1 37  ? 7.56452   11.17592  4.48432   1.000 4.49135  ? 39  PRO B N   1 
ATOM   2556 C CA  . PRO B 1 37  ? 8.88988   10.66122  4.85959   1.000 6.99219  ? 39  PRO B CA  1 
ATOM   2557 C C   . PRO B 1 37  ? 9.54584   11.54887  5.90933   1.000 5.20795  ? 39  PRO B C   1 
ATOM   2558 O O   . PRO B 1 37  ? 9.46414   12.77638  5.84968   1.000 5.01825  ? 39  PRO B O   1 
ATOM   2559 C CB  . PRO B 1 37  ? 9.66520   10.67895  3.53728   1.000 4.61126  ? 39  PRO B CB  1 
ATOM   2560 C CG  . PRO B 1 37  ? 8.55065   10.59591  2.47612   1.000 3.34191  ? 39  PRO B CG  1 
ATOM   2561 C CD  . PRO B 1 37  ? 7.45929   11.41231  3.02938   1.000 2.96673  ? 39  PRO B CD  1 
ATOM   2562 N N   . ARG B 1 38  ? 10.18550  10.91813  6.89224   1.000 3.30626  ? 40  ARG B N   1 
ATOM   2563 C CA  . ARG B 1 38  ? 10.84548  11.72523  7.91114   1.000 7.33307  ? 40  ARG B CA  1 
ATOM   2564 C C   . ARG B 1 38  ? 12.05160  12.47241  7.35351   1.000 10.06605 ? 40  ARG B C   1 
ATOM   2565 O O   . ARG B 1 38  ? 12.51253  13.44001  7.97233   1.000 8.57556  ? 40  ARG B O   1 
ATOM   2566 C CB  . ARG B 1 38  ? 11.26381  10.85411  9.09470   1.000 10.76423 ? 40  ARG B CB  1 
ATOM   2567 C CG  . ARG B 1 38  ? 12.27203  9.78326   8.74919   1.000 5.80231  ? 40  ARG B CG  1 
ATOM   2568 C CD  . ARG B 1 38  ? 13.09999  9.40207   9.96645   1.000 6.48374  ? 40  ARG B CD  1 
ATOM   2569 N NE  . ARG B 1 38  ? 14.09981  8.40808   9.60165   1.000 7.84606  ? 40  ARG B NE  1 
ATOM   2570 C CZ  . ARG B 1 38  ? 14.74791  7.64307   10.47413  1.000 11.95302 ? 40  ARG B CZ  1 
ATOM   2571 N NH1 . ARG B 1 38  ? 14.49268  7.75705   11.77421  1.000 7.88923  ? 40  ARG B NH1 1 
ATOM   2572 N NH2 . ARG B 1 38  ? 15.65973  6.77486   10.04863  1.000 9.63777  ? 40  ARG B NH2 1 
ATOM   2573 N N   . HIS B 1 39  ? 12.55386  12.07238  6.18423   1.000 7.97426  ? 41  HIS B N   1 
ATOM   2574 C CA  . HIS B 1 39  ? 13.70479  12.78901  5.65505   1.000 10.73636 ? 41  HIS B CA  1 
ATOM   2575 C C   . HIS B 1 39  ? 13.35554  14.19667  5.18637   1.000 10.61340 ? 41  HIS B C   1 
ATOM   2576 O O   . HIS B 1 39  ? 14.25800  14.92512  4.77453   1.000 15.07952 ? 41  HIS B O   1 
ATOM   2577 C CB  . HIS B 1 39  ? 14.38635  11.97142  4.54606   1.000 8.22820  ? 41  HIS B CB  1 
ATOM   2578 C CG  . HIS B 1 39  ? 13.63496  11.89581  3.24561   1.000 11.62377 ? 41  HIS B CG  1 
ATOM   2579 N ND1 . HIS B 1 39  ? 13.32826  13.00626  2.48594   1.000 12.14342 ? 41  HIS B ND1 1 
ATOM   2580 C CD2 . HIS B 1 39  ? 13.21200  10.82543  2.52915   1.000 5.97088  ? 41  HIS B CD2 1 
ATOM   2581 C CE1 . HIS B 1 39  ? 12.71855  12.62343  1.37699   1.000 13.42899 ? 41  HIS B CE1 1 
ATOM   2582 N NE2 . HIS B 1 39  ? 12.63836  11.30533  1.37890   1.000 7.15964  ? 41  HIS B NE2 1 
ATOM   2583 N N   . VAL B 1 40  ? 12.09066  14.61694  5.28954   1.000 9.77462  ? 42  VAL B N   1 
ATOM   2584 C CA  . VAL B 1 40  ? 11.74816  16.01339  5.02534   1.000 14.01999 ? 42  VAL B CA  1 
ATOM   2585 C C   . VAL B 1 40  ? 12.37247  16.96635  6.04081   1.000 14.59001 ? 42  VAL B C   1 
ATOM   2586 O O   . VAL B 1 40  ? 12.48325  18.16543  5.75970   1.000 20.52832 ? 42  VAL B O   1 
ATOM   2587 C CB  . VAL B 1 40  ? 10.21978  16.21971  5.00322   1.000 8.01160  ? 42  VAL B CB  1 
ATOM   2588 C CG1 . VAL B 1 40  ? 9.63422   16.10020  6.40958   1.000 7.04141  ? 42  VAL B CG1 1 
ATOM   2589 C CG2 . VAL B 1 40  ? 9.86333   17.56548  4.37476   1.000 12.01631 ? 42  VAL B CG2 1 
ATOM   2590 N N   . ILE B 1 41  ? 12.76722  16.48196  7.22709   1.000 12.02179 ? 43  ILE B N   1 
ATOM   2591 C CA  . ILE B 1 41  ? 13.45056  17.35403  8.18450   1.000 15.91515 ? 43  ILE B CA  1 
ATOM   2592 C C   . ILE B 1 41  ? 14.96475  17.37308  7.98209   1.000 18.44293 ? 43  ILE B C   1 
ATOM   2593 O O   . ILE B 1 41  ? 15.65638  18.17972  8.62235   1.000 22.48350 ? 43  ILE B O   1 
ATOM   2594 C CB  . ILE B 1 41  ? 13.09567  16.97734  9.63956   1.000 12.78598 ? 43  ILE B CB  1 
ATOM   2595 C CG1 . ILE B 1 41  ? 13.81151  15.69099  10.07875  1.000 11.58942 ? 43  ILE B CG1 1 
ATOM   2596 C CG2 . ILE B 1 41  ? 11.56949  16.88160  9.81821   1.000 13.85051 ? 43  ILE B CG2 1 
ATOM   2597 C CD1 . ILE B 1 41  ? 13.45018  15.24212  11.48774  1.000 12.72747 ? 43  ILE B CD1 1 
ATOM   2598 N N   . CYS B 1 42  ? 15.50124  16.52345  7.10788   1.000 21.61606 ? 44  CYS B N   1 
ATOM   2599 C CA  . CYS B 1 42  ? 16.89741  16.63034  6.69962   1.000 17.45065 ? 44  CYS B CA  1 
ATOM   2600 C C   . CYS B 1 42  ? 17.10339  17.93345  5.94065   1.000 24.63693 ? 44  CYS B C   1 
ATOM   2601 O O   . CYS B 1 42  ? 16.22303  18.37883  5.19959   1.000 30.22243 ? 44  CYS B O   1 
ATOM   2602 C CB  . CYS B 1 42  ? 17.26745  15.44602  5.81026   1.000 13.71365 ? 44  CYS B CB  1 
ATOM   2603 S SG  . CYS B 1 42  ? 18.97335  14.87008  5.83379   1.000 35.90167 ? 44  CYS B SG  1 
ATOM   2604 N N   . THR B 1 43  ? 18.25509  18.56644  6.13300   1.000 31.65605 ? 45  THR B N   1 
ATOM   2605 C CA  . THR B 1 43  ? 18.61891  19.69115  5.28055   1.000 34.90159 ? 45  THR B CA  1 
ATOM   2606 C C   . THR B 1 43  ? 19.75831  19.29274  4.35702   1.000 31.69543 ? 45  THR B C   1 
ATOM   2607 O O   . THR B 1 43  ? 20.36341  18.22793  4.49774   1.000 25.61890 ? 45  THR B O   1 
ATOM   2608 C CB  . THR B 1 43  ? 19.00362  20.93519  6.09057   1.000 40.53656 ? 45  THR B CB  1 
ATOM   2609 O OG1 . THR B 1 43  ? 20.05798  20.61517  7.00791   1.000 43.67238 ? 45  THR B OG1 1 
ATOM   2610 C CG2 . THR B 1 43  ? 17.78733  21.48932  6.83540   1.000 25.41670 ? 45  THR B CG2 1 
ATOM   2611 N N   . SER B 1 44  ? 20.02056  20.16933  3.38571   1.000 33.91499 ? 46  SER B N   1 
ATOM   2612 C CA  . SER B 1 44  ? 21.02071  19.87807  2.36781   1.000 42.01944 ? 46  SER B CA  1 
ATOM   2613 C C   . SER B 1 44  ? 22.38468  19.59297  2.98117   1.000 34.90729 ? 46  SER B C   1 
ATOM   2614 O O   . SER B 1 44  ? 23.14518  18.77361  2.45268   1.000 41.69624 ? 46  SER B O   1 
ATOM   2615 C CB  . SER B 1 44  ? 21.10037  21.04307  1.38126   1.000 42.63841 ? 46  SER B CB  1 
ATOM   2616 O OG  . SER B 1 44  ? 22.35286  21.07577  0.72551   1.000 49.54620 ? 46  SER B OG  1 
ATOM   2617 N N   . GLU B 1 45  ? 22.69541  20.21838  4.11573   1.000 43.88442 ? 47  GLU B N   1 
ATOM   2618 C CA  . GLU B 1 45  ? 24.03256  20.09539  4.68129   1.000 37.84198 ? 47  GLU B CA  1 
ATOM   2619 C C   . GLU B 1 45  ? 24.25958  18.76049  5.37885   1.000 37.24782 ? 47  GLU B C   1 
ATOM   2620 O O   . GLU B 1 45  ? 25.39377  18.27994  5.41903   1.000 46.75851 ? 47  GLU B O   1 
ATOM   2621 C CB  . GLU B 1 45  ? 24.29132  21.24541  5.65732   1.000 45.14117 ? 47  GLU B CB  1 
ATOM   2622 C CG  . GLU B 1 45  ? 23.69990  22.58574  5.22457   1.000 48.39723 ? 47  GLU B CG  1 
ATOM   2623 C CD  . GLU B 1 45  ? 24.14279  23.02467  3.82720   1.000 55.11889 ? 47  GLU B CD  1 
ATOM   2624 O OE1 . GLU B 1 45  ? 25.33193  22.82794  3.47013   1.000 56.86161 ? 47  GLU B OE1 1 
ATOM   2625 O OE2 . GLU B 1 45  ? 23.29686  23.58036  3.08691   1.000 54.06500 ? 47  GLU B OE2 1 
ATOM   2626 N N   . ASP B 1 46  ? 23.21829  18.14804  5.93576   1.000 39.15984 ? 48  ASP B N   1 
ATOM   2627 C CA  . ASP B 1 46  ? 23.36284  16.95196  6.76164   1.000 39.89441 ? 48  ASP B CA  1 
ATOM   2628 C C   . ASP B 1 46  ? 22.76884  15.71112  6.09608   1.000 35.86232 ? 48  ASP B C   1 
ATOM   2629 O O   . ASP B 1 46  ? 22.37370  14.76189  6.78146   1.000 31.72186 ? 48  ASP B O   1 
ATOM   2630 C CB  . ASP B 1 46  ? 22.72116  17.16961  8.13187   1.000 42.85303 ? 48  ASP B CB  1 
ATOM   2631 C CG  . ASP B 1 46  ? 21.39893  17.90862  8.03861   1.000 43.69539 ? 48  ASP B CG  1 
ATOM   2632 O OD1 . ASP B 1 46  ? 21.27549  18.77711  7.14424   1.000 41.93841 ? 48  ASP B OD1 1 
ATOM   2633 O OD2 . ASP B 1 46  ? 20.48763  17.62650  8.84899   1.000 44.22837 ? 48  ASP B OD2 1 
ATOM   2634 N N   . MET B 1 47  ? 22.71375  15.70154  4.75970   1.000 31.65203 ? 49  MET B N   1 
ATOM   2635 C CA  . MET B 1 47  ? 22.16292  14.55554  4.04048   1.000 27.11320 ? 49  MET B CA  1 
ATOM   2636 C C   . MET B 1 47  ? 22.96524  13.28483  4.28629   1.000 24.26384 ? 49  MET B C   1 
ATOM   2637 O O   . MET B 1 47  ? 22.40581  12.18067  4.23440   1.000 16.21976 ? 49  MET B O   1 
ATOM   2638 C CB  . MET B 1 47  ? 22.12039  14.85006  2.54415   1.000 24.70986 ? 49  MET B CB  1 
ATOM   2639 C CG  . MET B 1 47  ? 21.17970  15.96460  2.15924   1.000 36.20321 ? 49  MET B CG  1 
ATOM   2640 S SD  . MET B 1 47  ? 21.00180  16.07701  0.36774   1.000 44.27295 ? 49  MET B SD  1 
ATOM   2641 C CE  . MET B 1 47  ? 19.54818  17.12687  0.22449   1.000 41.95638 ? 49  MET B CE  1 
ATOM   2642 N N   . LEU B 1 48  ? 24.26683  13.41932  4.56854   1.000 14.54577 ? 50  LEU B N   1 
ATOM   2643 C CA  . LEU B 1 48  ? 25.15427  12.25905  4.58387   1.000 16.43782 ? 50  LEU B CA  1 
ATOM   2644 C C   . LEU B 1 48  ? 24.92941  11.38322  5.80964   1.000 20.38694 ? 50  LEU B C   1 
ATOM   2645 O O   . LEU B 1 48  ? 25.01237  10.15323  5.71873   1.000 25.26939 ? 50  LEU B O   1 
ATOM   2646 C CB  . LEU B 1 48  ? 26.62095  12.71349  4.50254   1.000 17.12572 ? 50  LEU B CB  1 
ATOM   2647 C CG  . LEU B 1 48  ? 27.09017  13.05879  3.08764   1.000 19.77192 ? 50  LEU B CG  1 
ATOM   2648 C CD1 . LEU B 1 48  ? 28.48239  13.72758  3.05728   1.000 12.96585 ? 50  LEU B CD1 1 
ATOM   2649 C CD2 . LEU B 1 48  ? 27.04952  11.80417  2.21777   1.000 20.04043 ? 50  LEU B CD2 1 
ATOM   2650 N N   . ASN B 1 49  ? 24.65858  11.98211  6.96816   1.000 17.95927 ? 51  ASN B N   1 
ATOM   2651 C CA  . ASN B 1 49  ? 24.45199  11.21583  8.19543   1.000 23.24231 ? 51  ASN B CA  1 
ATOM   2652 C C   . ASN B 1 49  ? 23.52131  11.98425  9.12775   1.000 26.35879 ? 51  ASN B C   1 
ATOM   2653 O O   . ASN B 1 49  ? 23.93611  12.49350  10.17256  1.000 28.62327 ? 51  ASN B O   1 
ATOM   2654 C CB  . ASN B 1 49  ? 25.78496  10.90704  8.87375   1.000 29.72442 ? 51  ASN B CB  1 
ATOM   2655 C CG  . ASN B 1 49  ? 25.64869  9.85480   9.95100   1.000 43.05335 ? 51  ASN B CG  1 
ATOM   2656 O OD1 . ASN B 1 49  ? 25.32119  10.16469  11.09797  1.000 52.82403 ? 51  ASN B OD1 1 
ATOM   2657 N ND2 . ASN B 1 49  ? 25.87918  8.59483   9.58378   1.000 40.86186 ? 51  ASN B ND2 1 
ATOM   2658 N N   . PRO B 1 50  ? 22.23981  12.05996  8.77952   1.000 26.07233 ? 52  PRO B N   1 
ATOM   2659 C CA  . PRO B 1 50  ? 21.28777  12.73708  9.66151   1.000 24.25674 ? 52  PRO B CA  1 
ATOM   2660 C C   . PRO B 1 50  ? 21.10612  11.96143  10.95440  1.000 18.09949 ? 52  PRO B C   1 
ATOM   2661 O O   . PRO B 1 50  ? 21.19028  10.73354  10.98970  1.000 20.10300 ? 52  PRO B O   1 
ATOM   2662 C CB  . PRO B 1 50  ? 19.99429  12.75648  8.83608   1.000 23.16870 ? 52  PRO B CB  1 
ATOM   2663 C CG  . PRO B 1 50  ? 20.10037  11.54611  7.98149   1.000 21.32020 ? 52  PRO B CG  1 
ATOM   2664 C CD  . PRO B 1 50  ? 21.56519  11.36120  7.67368   1.000 20.13872 ? 52  PRO B CD  1 
ATOM   2665 N N   . ASN B 1 51  ? 20.90370  12.70688  12.03065  1.000 18.92232 ? 53  ASN B N   1 
ATOM   2666 C CA  . ASN B 1 51  ? 20.54628  12.17098  13.34252  1.000 24.34229 ? 53  ASN B CA  1 
ATOM   2667 C C   . ASN B 1 51  ? 19.10466  12.62424  13.54287  1.000 18.50920 ? 53  ASN B C   1 
ATOM   2668 O O   . ASN B 1 51  ? 18.83430  13.75853  13.93935  1.000 22.26588 ? 53  ASN B O   1 
ATOM   2669 C CB  . ASN B 1 51  ? 21.50540  12.67535  14.42779  1.000 21.48144 ? 53  ASN B CB  1 
ATOM   2670 C CG  . ASN B 1 51  ? 21.08155  12.28449  15.84807  1.000 28.42156 ? 53  ASN B CG  1 
ATOM   2671 O OD1 . ASN B 1 51  ? 20.01739  11.70197  16.08591  1.000 22.65927 ? 53  ASN B OD1 1 
ATOM   2672 N ND2 . ASN B 1 51  ? 21.93557  12.61886  16.80593  1.000 25.75775 ? 53  ASN B ND2 1 
ATOM   2673 N N   . TYR B 1 52  ? 18.17086  11.73716  13.21554  1.000 23.06905 ? 54  TYR B N   1 
ATOM   2674 C CA  . TYR B 1 52  ? 16.80205  12.19301  13.04116  1.000 17.80111 ? 54  TYR B CA  1 
ATOM   2675 C C   . TYR B 1 52  ? 16.13274  12.48466  14.37213  1.000 16.50508 ? 54  TYR B C   1 
ATOM   2676 O O   . TYR B 1 52  ? 15.32724  13.41591  14.46037  1.000 15.98293 ? 54  TYR B O   1 
ATOM   2677 C CB  . TYR B 1 52  ? 16.00026  11.17030  12.23296  1.000 17.98048 ? 54  TYR B CB  1 
ATOM   2678 C CG  . TYR B 1 52  ? 16.21472  11.25489  10.72932  1.000 12.52604 ? 54  TYR B CG  1 
ATOM   2679 C CD1 . TYR B 1 52  ? 15.77271  12.35538  10.00360  1.000 13.85144 ? 54  TYR B CD1 1 
ATOM   2680 C CD2 . TYR B 1 52  ? 16.84197  10.22890  10.03939  1.000 8.67573  ? 54  TYR B CD2 1 
ATOM   2681 C CE1 . TYR B 1 52  ? 15.96748  12.44215  8.63123   1.000 8.65762  ? 54  TYR B CE1 1 
ATOM   2682 C CE2 . TYR B 1 52  ? 17.02226  10.29757  8.66989   1.000 9.55287  ? 54  TYR B CE2 1 
ATOM   2683 C CZ  . TYR B 1 52  ? 16.58254  11.40683  7.97049   1.000 10.95985 ? 54  TYR B CZ  1 
ATOM   2684 O OH  . TYR B 1 52  ? 16.76582  11.48812  6.60447   1.000 13.46334 ? 54  TYR B OH  1 
ATOM   2685 N N   . GLU B 1 53  ? 16.44150  11.72545  15.42300  1.000 21.59008 ? 55  GLU B N   1 
ATOM   2686 C CA  . GLU B 1 53  ? 15.82570  12.08077  16.69616  1.000 25.50185 ? 55  GLU B CA  1 
ATOM   2687 C C   . GLU B 1 53  ? 16.31523  13.44397  17.17439  1.000 26.50275 ? 55  GLU B C   1 
ATOM   2688 O O   . GLU B 1 53  ? 15.52386  14.22189  17.72474  1.000 27.67403 ? 55  GLU B O   1 
ATOM   2689 C CB  . GLU B 1 53  ? 16.04713  10.98855  17.74963  1.000 26.15550 ? 55  GLU B CB  1 
ATOM   2690 C CG  . GLU B 1 53  ? 17.45045  10.44516  17.94037  1.000 31.34222 ? 55  GLU B CG  1 
ATOM   2691 C CD  . GLU B 1 53  ? 17.48279  9.33566   19.00088  1.000 31.88430 ? 55  GLU B CD  1 
ATOM   2692 O OE1 . GLU B 1 53  ? 18.55896  9.09922   19.60229  1.000 35.59392 ? 55  GLU B OE1 1 
ATOM   2693 O OE2 . GLU B 1 53  ? 16.42135  8.70052   19.23072  1.000 25.58694 ? 55  GLU B OE2 1 
ATOM   2694 N N   . ASP B 1 54  ? 17.58195  13.78129  16.89348  1.000 23.84742 ? 56  ASP B N   1 
ATOM   2695 C CA  . ASP B 1 54  ? 18.09604  15.11260  17.20939  1.000 23.69962 ? 56  ASP B CA  1 
ATOM   2696 C C   . ASP B 1 54  ? 17.40303  16.20059  16.38885  1.000 20.34729 ? 56  ASP B C   1 
ATOM   2697 O O   . ASP B 1 54  ? 16.93942  17.20153  16.94233  1.000 20.45687 ? 56  ASP B O   1 
ATOM   2698 C CB  . ASP B 1 54  ? 19.60049  15.16359  16.96896  1.000 21.92713 ? 56  ASP B CB  1 
ATOM   2699 C CG  . ASP B 1 54  ? 20.27621  16.28044  17.74139  1.000 32.09357 ? 56  ASP B CG  1 
ATOM   2700 O OD1 . ASP B 1 54  ? 19.72940  16.71804  18.78253  1.000 30.13404 ? 56  ASP B OD1 1 
ATOM   2701 O OD2 . ASP B 1 54  ? 21.34733  16.73544  17.29200  1.000 36.06182 ? 56  ASP B OD2 1 
ATOM   2702 N N   . LEU B 1 55  ? 17.35279  16.04104  15.06107  1.000 18.21682 ? 57  LEU B N   1 
ATOM   2703 C CA  . LEU B 1 55  ? 16.69525  17.04106  14.21888  1.000 19.09951 ? 57  LEU B CA  1 
ATOM   2704 C C   . LEU B 1 55  ? 15.22565  17.22708  14.60102  1.000 21.52907 ? 57  LEU B C   1 
ATOM   2705 O O   . LEU B 1 55  ? 14.69945  18.34631  14.54412  1.000 20.36393 ? 57  LEU B O   1 
ATOM   2706 C CB  . LEU B 1 55  ? 16.81231  16.64736  12.74338  1.000 19.70389 ? 57  LEU B CB  1 
ATOM   2707 C CG  . LEU B 1 55  ? 18.17622  16.74706  12.05915  1.000 19.85412 ? 57  LEU B CG  1 
ATOM   2708 C CD1 . LEU B 1 55  ? 18.37216  15.58328  11.10739  1.000 18.13755 ? 57  LEU B CD1 1 
ATOM   2709 C CD2 . LEU B 1 55  ? 18.28404  18.05868  11.30301  1.000 18.40505 ? 57  LEU B CD2 1 
ATOM   2710 N N   . LEU B 1 56  ? 14.54365  16.14237  14.98761  1.000 19.46025 ? 58  LEU B N   1 
ATOM   2711 C CA  . LEU B 1 56  ? 13.14030  16.24357  15.37057  1.000 22.05319 ? 58  LEU B CA  1 
ATOM   2712 C C   . LEU B 1 56  ? 12.96434  16.85647  16.75759  1.000 26.58090 ? 58  LEU B C   1 
ATOM   2713 O O   . LEU B 1 56  ? 11.98483  17.57732  16.98688  1.000 25.28717 ? 58  LEU B O   1 
ATOM   2714 C CB  . LEU B 1 56  ? 12.47279  14.86433  15.31109  1.000 19.60864 ? 58  LEU B CB  1 
ATOM   2715 C CG  . LEU B 1 56  ? 10.95067  14.82711  15.53468  1.000 24.66886 ? 58  LEU B CG  1 
ATOM   2716 C CD1 . LEU B 1 56  ? 10.20780  15.64912  14.49348  1.000 22.17224 ? 58  LEU B CD1 1 
ATOM   2717 C CD2 . LEU B 1 56  ? 10.42805  13.40077  15.54280  1.000 22.14703 ? 58  LEU B CD2 1 
ATOM   2718 N N   . ILE B 1 57  ? 13.88807  16.58548  17.69062  1.000 32.08812 ? 59  ILE B N   1 
ATOM   2719 C CA  . ILE B 1 57  ? 13.80793  17.20869  19.01499  1.000 30.72930 ? 59  ILE B CA  1 
ATOM   2720 C C   . ILE B 1 57  ? 13.90525  18.72562  18.89012  1.000 26.80036 ? 59  ILE B C   1 
ATOM   2721 O O   . ILE B 1 57  ? 13.12286  19.46188  19.50542  1.000 25.38265 ? 59  ILE B O   1 
ATOM   2722 C CB  . ILE B 1 57  ? 14.88623  16.63145  19.95750  1.000 29.85864 ? 59  ILE B CB  1 
ATOM   2723 C CG1 . ILE B 1 57  ? 14.54643  15.18681  20.34203  1.000 25.79265 ? 59  ILE B CG1 1 
ATOM   2724 C CG2 . ILE B 1 57  ? 15.04323  17.48962  21.20604  1.000 26.69398 ? 59  ILE B CG2 1 
ATOM   2725 C CD1 . ILE B 1 57  ? 13.79501  15.02637  21.64317  1.000 30.19037 ? 59  ILE B CD1 1 
ATOM   2726 N N   . ARG B 1 58  ? 14.82422  19.21432  18.04574  1.000 24.13537 ? 60  ARG B N   1 
ATOM   2727 C CA  . ARG B 1 58  ? 14.95289  20.64633  17.78662  1.000 24.50456 ? 60  ARG B CA  1 
ATOM   2728 C C   . ARG B 1 58  ? 13.75316  21.24325  17.05299  1.000 31.12632 ? 60  ARG B C   1 
ATOM   2729 O O   . ARG B 1 58  ? 13.63190  22.47405  17.00866  1.000 26.96646 ? 60  ARG B O   1 
ATOM   2730 C CB  . ARG B 1 58  ? 16.22195  20.92661  16.97708  1.000 23.92425 ? 60  ARG B CB  1 
ATOM   2731 N N   . LYS B 1 59  ? 12.88055  20.42072  16.46938  1.000 33.69369 ? 61  LYS B N   1 
ATOM   2732 C CA  . LYS B 1 59  ? 11.75710  20.92809  15.69194  1.000 27.31975 ? 61  LYS B CA  1 
ATOM   2733 C C   . LYS B 1 59  ? 10.60217  21.30398  16.60384  1.000 27.42998 ? 61  LYS B C   1 
ATOM   2734 O O   . LYS B 1 59  ? 10.40233  20.70002  17.66352  1.000 27.27268 ? 61  LYS B O   1 
ATOM   2735 C CB  . LYS B 1 59  ? 11.26479  19.88257  14.68407  1.000 27.76275 ? 61  LYS B CB  1 
ATOM   2736 C CG  . LYS B 1 59  ? 12.11911  19.70096  13.44043  1.000 20.70528 ? 61  LYS B CG  1 
ATOM   2737 C CD  . LYS B 1 59  ? 12.30965  21.00324  12.68964  1.000 22.63222 ? 61  LYS B CD  1 
ATOM   2738 C CE  . LYS B 1 59  ? 13.17327  20.79093  11.46613  1.000 21.22534 ? 61  LYS B CE  1 
ATOM   2739 N NZ  . LYS B 1 59  ? 13.51305  22.08012  10.79057  1.000 27.71192 ? 61  LYS B NZ  1 
ATOM   2740 N N   . SER B 1 60  ? 9.81967   22.28786  16.15973  1.000 24.83809 ? 62  SER B N   1 
ATOM   2741 C CA  . SER B 1 60  ? 8.54799   22.65438  16.77421  1.000 29.34792 ? 62  SER B CA  1 
ATOM   2742 C C   . SER B 1 60  ? 7.43069   22.60204  15.73436  1.000 26.56924 ? 62  SER B C   1 
ATOM   2743 O O   . SER B 1 60  ? 7.67628   22.49026  14.52890  1.000 22.38961 ? 62  SER B O   1 
ATOM   2744 C CB  . SER B 1 60  ? 8.61967   24.04792  17.41305  1.000 35.45275 ? 62  SER B CB  1 
ATOM   2745 O OG  . SER B 1 60  ? 9.28496   24.01426  18.66737  1.000 39.98711 ? 62  SER B OG  1 
ATOM   2746 N N   . ASN B 1 61  ? 6.18446   22.69148  16.21624  1.000 26.74470 ? 63  ASN B N   1 
ATOM   2747 C CA  . ASN B 1 61  ? 5.03304   22.55918  15.32338  1.000 24.74803 ? 63  ASN B CA  1 
ATOM   2748 C C   . ASN B 1 61  ? 5.08226   23.57642  14.19319  1.000 26.66279 ? 63  ASN B C   1 
ATOM   2749 O O   . ASN B 1 61  ? 4.77624   23.24837  13.03981  1.000 26.41835 ? 63  ASN B O   1 
ATOM   2750 C CB  . ASN B 1 61  ? 3.72692   22.69661  16.10587  1.000 21.22999 ? 63  ASN B CB  1 
ATOM   2751 C CG  . ASN B 1 61  ? 3.39852   21.45414  16.89466  1.000 22.85063 ? 63  ASN B CG  1 
ATOM   2752 O OD1 . ASN B 1 61  ? 3.87406   20.37018  16.56983  1.000 23.76594 ? 63  ASN B OD1 1 
ATOM   2753 N ND2 . ASN B 1 61  ? 2.58968   21.60002  17.94618  1.000 24.18496 ? 63  ASN B ND2 1 
ATOM   2754 N N   . HIS B 1 62  ? 5.48951   24.80898  14.49796  1.000 29.30406 ? 64  HIS B N   1 
ATOM   2755 C CA  . HIS B 1 62  ? 5.52258   25.86685  13.49543  1.000 30.64354 ? 64  HIS B CA  1 
ATOM   2756 C C   . HIS B 1 62  ? 6.59817   25.65234  12.43677  1.000 25.00860 ? 64  HIS B C   1 
ATOM   2757 O O   . HIS B 1 62  ? 6.61001   26.38559  11.44333  1.000 26.54665 ? 64  HIS B O   1 
ATOM   2758 C CB  . HIS B 1 62  ? 5.72625   27.22434  14.17346  1.000 29.66890 ? 64  HIS B CB  1 
ATOM   2759 C CG  . HIS B 1 62  ? 6.82521   27.22865  15.19258  1.000 32.46236 ? 64  HIS B CG  1 
ATOM   2760 N ND1 . HIS B 1 62  ? 6.58816   27.36869  16.54476  1.000 32.93745 ? 64  HIS B ND1 1 
ATOM   2761 C CD2 . HIS B 1 62  ? 8.16880   27.10066  15.05709  1.000 32.91941 ? 64  HIS B CD2 1 
ATOM   2762 C CE1 . HIS B 1 62  ? 7.73738   27.33073  17.19763  1.000 31.81920 ? 64  HIS B CE1 1 
ATOM   2763 N NE2 . HIS B 1 62  ? 8.71197   27.16545  16.31852  1.000 35.00347 ? 64  HIS B NE2 1 
ATOM   2764 N N   . ASN B 1 63  ? 7.48820   24.67243  12.61270  1.000 23.86748 ? 65  ASN B N   1 
ATOM   2765 C CA  . ASN B 1 63  ? 8.47038   24.35710  11.57636  1.000 24.45192 ? 65  ASN B CA  1 
ATOM   2766 C C   . ASN B 1 63  ? 7.85861   23.67513  10.35075  1.000 25.42590 ? 65  ASN B C   1 
ATOM   2767 O O   . ASN B 1 63  ? 8.56116   23.49825  9.34740   1.000 24.29738 ? 65  ASN B O   1 
ATOM   2768 C CB  . ASN B 1 63  ? 9.57799   23.46044  12.14253  1.000 20.73155 ? 65  ASN B CB  1 
ATOM   2769 C CG  . ASN B 1 63  ? 10.49550  24.19373  13.11053  1.000 29.36959 ? 65  ASN B CG  1 
ATOM   2770 O OD1 . ASN B 1 63  ? 10.51317  23.90752  14.31273  1.000 29.31412 ? 65  ASN B OD1 1 
ATOM   2771 N ND2 . ASN B 1 63  ? 11.26273  25.14479  12.59075  1.000 20.94377 ? 65  ASN B ND2 1 
ATOM   2772 N N   . PHE B 1 64  ? 6.58695   23.28011  10.39838  1.000 24.63761 ? 66  PHE B N   1 
ATOM   2773 C CA  . PHE B 1 64  ? 5.97168   22.50042  9.33104   1.000 19.79468 ? 66  PHE B CA  1 
ATOM   2774 C C   . PHE B 1 64  ? 4.80753   23.27130  8.73084   1.000 26.52756 ? 66  PHE B C   1 
ATOM   2775 O O   . PHE B 1 64  ? 3.90928   23.72016  9.44963   1.000 32.00561 ? 66  PHE B O   1 
ATOM   2776 C CB  . PHE B 1 64  ? 5.48576   21.14042  9.83566   1.000 21.52185 ? 66  PHE B CB  1 
ATOM   2777 C CG  . PHE B 1 64  ? 6.56189   20.30457  10.46560  1.000 24.65492 ? 66  PHE B CG  1 
ATOM   2778 C CD1 . PHE B 1 64  ? 7.37494   19.49897  9.69064   1.000 17.56331 ? 66  PHE B CD1 1 
ATOM   2779 C CD2 . PHE B 1 64  ? 6.75490   20.32421  11.84009  1.000 21.95152 ? 66  PHE B CD2 1 
ATOM   2780 C CE1 . PHE B 1 64  ? 8.35516   18.73224  10.27654  1.000 15.63370 ? 66  PHE B CE1 1 
ATOM   2781 C CE2 . PHE B 1 64  ? 7.73473   19.56040  12.42887  1.000 15.44868 ? 66  PHE B CE2 1 
ATOM   2782 C CZ  . PHE B 1 64  ? 8.53493   18.76175  11.64345  1.000 22.54626 ? 66  PHE B CZ  1 
ATOM   2783 N N   . LEU B 1 65  ? 4.82382   23.39577  7.41425   1.000 23.44798 ? 67  LEU B N   1 
ATOM   2784 C CA  . LEU B 1 65  ? 3.81931   24.10597  6.63936   1.000 25.17820 ? 67  LEU B CA  1 
ATOM   2785 C C   . LEU B 1 65  ? 3.05596   23.06707  5.82035   1.000 26.91768 ? 67  LEU B C   1 
ATOM   2786 O O   . LEU B 1 65  ? 3.65438   22.37539  4.98915   1.000 23.64614 ? 67  LEU B O   1 
ATOM   2787 C CB  . LEU B 1 65  ? 4.51305   25.13939  5.74369   1.000 25.35695 ? 67  LEU B CB  1 
ATOM   2788 C CG  . LEU B 1 65  ? 3.78497   26.26348  5.00054   1.000 38.46541 ? 67  LEU B CG  1 
ATOM   2789 C CD1 . LEU B 1 65  ? 3.32511   25.82624  3.60808   1.000 38.12547 ? 67  LEU B CD1 1 
ATOM   2790 C CD2 . LEU B 1 65  ? 2.61234   26.79261  5.81404   1.000 39.88782 ? 67  LEU B CD2 1 
ATOM   2791 N N   . VAL B 1 66  ? 1.75266   22.93257  6.06727   1.000 22.46909 ? 68  VAL B N   1 
ATOM   2792 C CA  . VAL B 1 66  ? 0.92136   21.94032  5.38819   1.000 19.98931 ? 68  VAL B CA  1 
ATOM   2793 C C   . VAL B 1 66  ? -0.17268  22.65539  4.60504   1.000 21.83505 ? 68  VAL B C   1 
ATOM   2794 O O   . VAL B 1 66  ? -0.93132  23.44720  5.17625   1.000 22.17321 ? 68  VAL B O   1 
ATOM   2795 C CB  . VAL B 1 66  ? 0.30239   20.93879  6.37861   1.000 12.75674 ? 68  VAL B CB  1 
ATOM   2796 C CG1 . VAL B 1 66  ? -0.53275  19.92130  5.63297   1.000 15.44919 ? 68  VAL B CG1 1 
ATOM   2797 C CG2 . VAL B 1 66  ? 1.37847   20.25361  7.18116   1.000 15.84444 ? 68  VAL B CG2 1 
ATOM   2798 N N   . GLN B 1 67  ? -0.27253  22.35186  3.30660   1.000 22.35129 ? 69  GLN B N   1 
ATOM   2799 C CA  . GLN B 1 67  ? -1.26801  22.95917  2.42515   1.000 22.09585 ? 69  GLN B CA  1 
ATOM   2800 C C   . GLN B 1 67  ? -2.07553  21.87410  1.73413   1.000 19.62481 ? 69  GLN B C   1 
ATOM   2801 O O   . GLN B 1 67  ? -1.51884  21.06540  0.98335   1.000 14.46753 ? 69  GLN B O   1 
ATOM   2802 C CB  . GLN B 1 67  ? -0.61984  23.85350  1.36839   1.000 24.08098 ? 69  GLN B CB  1 
ATOM   2803 C CG  . GLN B 1 67  ? 0.31411   24.89456  1.92179   1.000 29.71126 ? 69  GLN B CG  1 
ATOM   2804 C CD  . GLN B 1 67  ? 0.77231   25.84491  0.85154   1.000 43.66135 ? 69  GLN B CD  1 
ATOM   2805 O OE1 . GLN B 1 67  ? 1.97259   26.02744  0.63923   1.000 50.88430 ? 69  GLN B OE1 1 
ATOM   2806 N NE2 . GLN B 1 67  ? -0.18476  26.44479  0.14514   1.000 47.22537 ? 69  GLN B NE2 1 
ATOM   2807 N N   . ALA B 1 68  ? -3.38197  21.87208  1.97543   1.000 14.43984 ? 70  ALA B N   1 
ATOM   2808 C CA  . ALA B 1 68  ? -4.32662  21.00794  1.27504   1.000 21.55024 ? 70  ALA B CA  1 
ATOM   2809 C C   . ALA B 1 68  ? -5.04459  21.88476  0.25833   1.000 23.30726 ? 70  ALA B C   1 
ATOM   2810 O O   . ALA B 1 68  ? -5.91519  22.68182  0.61642   1.000 29.89751 ? 70  ALA B O   1 
ATOM   2811 C CB  . ALA B 1 68  ? -5.30592  20.35584  2.24429   1.000 13.94520 ? 70  ALA B CB  1 
ATOM   2812 N N   . GLY B 1 69  ? -4.67651  21.73980  -1.00932  1.000 25.14849 ? 71  GLY B N   1 
ATOM   2813 C CA  . GLY B 1 69  ? -5.12157  22.67978  -2.01840  1.000 31.05778 ? 71  GLY B CA  1 
ATOM   2814 C C   . GLY B 1 69  ? -4.57914  24.07239  -1.75487  1.000 36.83872 ? 71  GLY B C   1 
ATOM   2815 O O   . GLY B 1 69  ? -3.36204  24.29309  -1.79445  1.000 33.89736 ? 71  GLY B O   1 
ATOM   2816 N N   . ASN B 1 70  ? -5.47146  25.02208  -1.47544  1.000 32.36157 ? 72  ASN B N   1 
ATOM   2817 C CA  . ASN B 1 70  ? -5.07911  26.37854  -1.12021  1.000 31.18077 ? 72  ASN B CA  1 
ATOM   2818 C C   . ASN B 1 70  ? -5.41601  26.71620  0.32734   1.000 38.01414 ? 72  ASN B C   1 
ATOM   2819 O O   . ASN B 1 70  ? -5.32521  27.88572  0.71640   1.000 47.27692 ? 72  ASN B O   1 
ATOM   2820 C CB  . ASN B 1 70  ? -5.73114  27.39108  -2.06647  1.000 31.33302 ? 72  ASN B CB  1 
ATOM   2821 N N   . VAL B 1 71  ? -5.80411  25.72499  1.13158   1.000 33.48759 ? 73  VAL B N   1 
ATOM   2822 C CA  . VAL B 1 71  ? -6.05220  25.90590  2.55880   1.000 29.69439 ? 73  VAL B CA  1 
ATOM   2823 C C   . VAL B 1 71  ? -4.83577  25.41611  3.33438   1.000 27.23947 ? 73  VAL B C   1 
ATOM   2824 O O   . VAL B 1 71  ? -4.40011  24.27119  3.16540   1.000 29.10371 ? 73  VAL B O   1 
ATOM   2825 C CB  . VAL B 1 71  ? -7.31729  25.15727  3.00637   1.000 26.24590 ? 73  VAL B CB  1 
ATOM   2826 C CG1 . VAL B 1 71  ? -7.39097  25.12470  4.51725   1.000 25.91721 ? 73  VAL B CG1 1 
ATOM   2827 C CG2 . VAL B 1 71  ? -8.55647  25.80760  2.41812   1.000 31.40676 ? 73  VAL B CG2 1 
ATOM   2828 N N   . GLN B 1 72  ? -4.28069  26.27333  4.18117   1.000 26.20299 ? 74  GLN B N   1 
ATOM   2829 C CA  . GLN B 1 72  ? -3.16537  25.85884  5.01696   1.000 24.53541 ? 74  GLN B CA  1 
ATOM   2830 C C   . GLN B 1 72  ? -3.71352  25.12596  6.22803   1.000 24.90948 ? 74  GLN B C   1 
ATOM   2831 O O   . GLN B 1 72  ? -4.63451  25.61284  6.88746   1.000 29.11173 ? 74  GLN B O   1 
ATOM   2832 C CB  . GLN B 1 72  ? -2.32784  27.06215  5.44749   1.000 24.24421 ? 74  GLN B CB  1 
ATOM   2833 N N   . LEU B 1 73  ? -3.16615  23.94877  6.51111   1.000 28.35516 ? 75  LEU B N   1 
ATOM   2834 C CA  . LEU B 1 73  ? -3.54779  23.19525  7.69948   1.000 26.91193 ? 75  LEU B CA  1 
ATOM   2835 C C   . LEU B 1 73  ? -2.63645  23.57855  8.86224   1.000 26.58649 ? 75  LEU B C   1 
ATOM   2836 O O   . LEU B 1 73  ? -1.40846  23.61770  8.71349   1.000 25.67529 ? 75  LEU B O   1 
ATOM   2837 C CB  . LEU B 1 73  ? -3.47939  21.68627  7.43882   1.000 24.18756 ? 75  LEU B CB  1 
ATOM   2838 C CG  . LEU B 1 73  ? -4.38425  21.10328  6.35095   1.000 22.29301 ? 75  LEU B CG  1 
ATOM   2839 C CD1 . LEU B 1 73  ? -4.35135  19.58403  6.37012   1.000 20.15784 ? 75  LEU B CD1 1 
ATOM   2840 C CD2 . LEU B 1 73  ? -5.80725  21.58814  6.52772   1.000 21.87129 ? 75  LEU B CD2 1 
ATOM   2841 N N   . ARG B 1 74  ? -3.24211  23.86494  10.01584  1.000 26.22623 ? 76  ARG B N   1 
ATOM   2842 C CA  . ARG B 1 74  ? -2.48558  24.22229  11.20874  1.000 22.29555 ? 76  ARG B CA  1 
ATOM   2843 C C   . ARG B 1 74  ? -2.02547  22.94656  11.90115  1.000 19.23359 ? 76  ARG B C   1 
ATOM   2844 O O   . ARG B 1 74  ? -2.85538  22.11741  12.29847  1.000 20.14008 ? 76  ARG B O   1 
ATOM   2845 C CB  . ARG B 1 74  ? -3.33045  25.07733  12.15235  1.000 27.92181 ? 76  ARG B CB  1 
ATOM   2846 N N   . VAL B 1 75  ? -0.70893  22.78405  12.01709  1.000 18.80126 ? 77  VAL B N   1 
ATOM   2847 C CA  . VAL B 1 75  ? -0.11034  21.64289  12.70545  1.000 20.88318 ? 77  VAL B CA  1 
ATOM   2848 C C   . VAL B 1 75  ? -0.15845  21.89540  14.20381  1.000 21.77946 ? 77  VAL B C   1 
ATOM   2849 O O   . VAL B 1 75  ? 0.31893   22.92994  14.68299  1.000 22.05500 ? 77  VAL B O   1 
ATOM   2850 C CB  . VAL B 1 75  ? 1.33996   21.41742  12.24060  1.000 14.65362 ? 77  VAL B CB  1 
ATOM   2851 C CG1 . VAL B 1 75  ? 2.00068   20.33232  13.07178  1.000 14.05380 ? 77  VAL B CG1 1 
ATOM   2852 C CG2 . VAL B 1 75  ? 1.38728   21.05048  10.77347  1.000 16.52125 ? 77  VAL B CG2 1 
ATOM   2853 N N   . ILE B 1 76  ? -0.72270  20.94436  14.95006  1.000 19.60709 ? 78  ILE B N   1 
ATOM   2854 C CA  . ILE B 1 76  ? -0.81308  21.03865  16.39908  1.000 18.17662 ? 78  ILE B CA  1 
ATOM   2855 C C   . ILE B 1 76  ? -0.01312  19.94690  17.10278  1.000 17.76456 ? 78  ILE B C   1 
ATOM   2856 O O   . ILE B 1 76  ? -0.04618  19.86076  18.32962  1.000 20.55076 ? 78  ILE B O   1 
ATOM   2857 C CB  . ILE B 1 76  ? -2.28271  21.03663  16.86834  1.000 16.32040 ? 78  ILE B CB  1 
ATOM   2858 C CG1 . ILE B 1 76  ? -2.92215  19.65970  16.65831  1.000 21.69630 ? 78  ILE B CG1 1 
ATOM   2859 C CG2 . ILE B 1 76  ? -3.06886  22.08901  16.11909  1.000 20.64883 ? 78  ILE B CG2 1 
ATOM   2860 C CD1 . ILE B 1 76  ? -4.33525  19.54761  17.18262  1.000 16.27289 ? 78  ILE B CD1 1 
ATOM   2861 N N   . GLY B 1 77  ? 0.73191   19.12710  16.35604  1.000 23.01035 ? 79  GLY B N   1 
ATOM   2862 C CA  . GLY B 1 77  ? 1.64045   18.16550  16.96513  1.000 18.05152 ? 79  GLY B CA  1 
ATOM   2863 C C   . GLY B 1 77  ? 2.47286   17.45953  15.91636  1.000 19.36992 ? 79  GLY B C   1 
ATOM   2864 O O   . GLY B 1 77  ? 2.13840   17.46005  14.72633  1.000 16.03201 ? 79  GLY B O   1 
ATOM   2865 N N   . HIS B 1 78  ? 3.57090   16.85033  16.37531  1.000 19.17975 ? 80  HIS B N   1 
ATOM   2866 C CA  . HIS B 1 78  ? 4.46132   16.10391  15.48888  1.000 17.28021 ? 80  HIS B CA  1 
ATOM   2867 C C   . HIS B 1 78  ? 5.08688   14.94650  16.25299  1.000 19.67872 ? 80  HIS B C   1 
ATOM   2868 O O   . HIS B 1 78  ? 5.26325   15.00151  17.47264  1.000 19.01157 ? 80  HIS B O   1 
ATOM   2869 C CB  . HIS B 1 78  ? 5.55723   16.98473  14.86914  1.000 16.43437 ? 80  HIS B CB  1 
ATOM   2870 C CG  . HIS B 1 78  ? 6.39466   17.71003  15.87530  1.000 23.38683 ? 80  HIS B CG  1 
ATOM   2871 N ND1 . HIS B 1 78  ? 5.88921   18.70194  16.69075  1.000 21.34566 ? 80  HIS B ND1 1 
ATOM   2872 C CD2 . HIS B 1 78  ? 7.70403   17.58347  16.20276  1.000 26.53123 ? 80  HIS B CD2 1 
ATOM   2873 C CE1 . HIS B 1 78  ? 6.85275   19.15489  17.47523  1.000 30.15699 ? 80  HIS B CE1 1 
ATOM   2874 N NE2 . HIS B 1 78  ? 7.96196   18.48978  17.20264  1.000 23.88950 ? 80  HIS B NE2 1 
ATOM   2875 N N   . SER B 1 79  ? 5.43012   13.90229  15.50964  1.000 19.79304 ? 81  SER B N   1 
ATOM   2876 C CA  . SER B 1 79  ? 5.77991   12.59718  16.04859  1.000 17.17659 ? 81  SER B CA  1 
ATOM   2877 C C   . SER B 1 79  ? 6.38770   11.76942  14.92072  1.000 19.76764 ? 81  SER B C   1 
ATOM   2878 O O   . SER B 1 79  ? 6.05407   11.96504  13.74957  1.000 15.23821 ? 81  SER B O   1 
ATOM   2879 C CB  . SER B 1 79  ? 4.53763   11.90936  16.62896  1.000 17.81768 ? 81  SER B CB  1 
ATOM   2880 O OG  . SER B 1 79  ? 4.69858   10.50881  16.71021  1.000 25.47670 ? 81  SER B OG  1 
ATOM   2881 N N   . MET B 1 80  ? 7.28656   10.85547  15.27445  1.000 14.95498 ? 82  MET B N   1 
ATOM   2882 C CA  . MET B 1 80  ? 7.92493   9.98546   14.29679  1.000 14.04390 ? 82  MET B CA  1 
ATOM   2883 C C   . MET B 1 80  ? 7.61414   8.52772   14.61108  1.000 10.21049 ? 82  MET B C   1 
ATOM   2884 O O   . MET B 1 80  ? 7.62757   8.11570   15.77634  1.000 11.87889 ? 82  MET B O   1 
ATOM   2885 C CB  . MET B 1 80  ? 9.44365   10.19344  14.28108  1.000 10.80501 ? 82  MET B CB  1 
ATOM   2886 C CG  . MET B 1 80  ? 10.03373  10.45647  12.90347  1.000 10.06602 ? 82  MET B CG  1 
ATOM   2887 S SD  . MET B 1 80  ? 11.77506  10.91548  13.03705  1.000 26.31652 ? 82  MET B SD  1 
ATOM   2888 C CE  . MET B 1 80  ? 12.40300  9.48465   13.87442  1.000 15.75515 ? 82  MET B CE  1 
ATOM   2889 N N   . GLN B 1 81  ? 7.32126   7.75191   13.57195  1.000 6.35981  ? 83  GLN B N   1 
ATOM   2890 C CA  . GLN B 1 81  ? 7.25331   6.29762   13.66677  1.000 7.38405  ? 83  GLN B CA  1 
ATOM   2891 C C   . GLN B 1 81  ? 8.20290   5.71407   12.62649  1.000 5.66569  ? 83  GLN B C   1 
ATOM   2892 O O   . GLN B 1 81  ? 7.95069   5.81309   11.42015  1.000 4.77069  ? 83  GLN B O   1 
ATOM   2893 C CB  . GLN B 1 81  ? 5.83237   5.78186   13.46403  1.000 10.82332 ? 83  GLN B CB  1 
ATOM   2894 C CG  . GLN B 1 81  ? 5.74408   4.26086   13.47121  1.000 9.05030  ? 83  GLN B CG  1 
ATOM   2895 C CD  . GLN B 1 81  ? 4.32406   3.76530   13.39062  1.000 9.47139  ? 83  GLN B CD  1 
ATOM   2896 O OE1 . GLN B 1 81  ? 3.42339   4.47841   12.93215  1.000 14.13115 ? 83  GLN B OE1 1 
ATOM   2897 N NE2 . GLN B 1 81  ? 4.10477   2.54181   13.85095  1.000 5.57191  ? 83  GLN B NE2 1 
ATOM   2898 N N   . ASN B 1 82  ? 9.30117   5.11685   13.09429  1.000 7.13357  ? 84  ASN B N   1 
ATOM   2899 C CA  . ASN B 1 82  ? 10.29786  4.57126   12.18593  1.000 5.39016  ? 84  ASN B CA  1 
ATOM   2900 C C   . ASN B 1 82  ? 10.66515  5.64893   11.17170  1.000 6.48749  ? 84  ASN B C   1 
ATOM   2901 O O   . ASN B 1 82  ? 11.00145  6.76719   11.56637  1.000 4.75771  ? 84  ASN B O   1 
ATOM   2902 C CB  . ASN B 1 82  ? 9.76001   3.29160   11.54190  1.000 6.24655  ? 84  ASN B CB  1 
ATOM   2903 C CG  . ASN B 1 82  ? 9.44318   2.21286   12.57961  1.000 7.44023  ? 84  ASN B CG  1 
ATOM   2904 O OD1 . ASN B 1 82  ? 10.24958  1.95198   13.48540  1.000 6.01838  ? 84  ASN B OD1 1 
ATOM   2905 N ND2 . ASN B 1 82  ? 8.28295   1.57513   12.45034  1.000 4.03126  ? 84  ASN B ND2 1 
ATOM   2906 N N   . CYS B 1 83  ? 10.52381  5.38621   9.87438   1.000 3.99500  ? 85  CYS B N   1 
ATOM   2907 C CA  . CYS B 1 83  ? 10.94499  6.37706   8.89703   1.000 5.00027  ? 85  CYS B CA  1 
ATOM   2908 C C   . CYS B 1 83  ? 9.82286   7.28395   8.37914   1.000 4.23313  ? 85  CYS B C   1 
ATOM   2909 O O   . CYS B 1 83  ? 10.04070  7.99827   7.39081   1.000 6.00698  ? 85  CYS B O   1 
ATOM   2910 C CB  . CYS B 1 83  ? 11.65291  5.68203   7.73229   1.000 4.81006  ? 85  CYS B CB  1 
ATOM   2911 S SG  . CYS B 1 83  ? 13.12669  4.72868   8.26828   1.000 5.34734  ? 85  CYS B SG  1 
ATOM   2912 N N   . VAL B 1 84  ? 8.64801   7.32298   9.01448   1.000 6.82243  ? 86  VAL B N   1 
ATOM   2913 C CA  . VAL B 1 84  ? 7.61423   8.27464   8.59993   1.000 5.20544  ? 86  VAL B CA  1 
ATOM   2914 C C   . VAL B 1 84  ? 7.37813   9.30220   9.70136   1.000 7.45719  ? 86  VAL B C   1 
ATOM   2915 O O   . VAL B 1 84  ? 7.40950   8.98633   10.90049  1.000 5.08758  ? 86  VAL B O   1 
ATOM   2916 C CB  . VAL B 1 84  ? 6.29290   7.60155   8.16925   1.000 5.84118  ? 86  VAL B CB  1 
ATOM   2917 C CG1 . VAL B 1 84  ? 6.53736   6.68432   6.98249   1.000 5.44934  ? 86  VAL B CG1 1 
ATOM   2918 C CG2 . VAL B 1 84  ? 5.60589   6.87599   9.33262   1.000 8.50608  ? 86  VAL B CG2 1 
ATOM   2919 N N   . LEU B 1 85  ? 7.20016   10.55026  9.27434   1.000 4.15647  ? 87  LEU B N   1 
ATOM   2920 C CA  . LEU B 1 85  ? 6.82942   11.65426  10.13977  1.000 7.69993  ? 87  LEU B CA  1 
ATOM   2921 C C   . LEU B 1 85  ? 5.30657   11.78546  10.17599  1.000 8.23845  ? 87  LEU B C   1 
ATOM   2922 O O   . LEU B 1 85  ? 4.64574   11.70270  9.13799   1.000 4.29713  ? 87  LEU B O   1 
ATOM   2923 C CB  . LEU B 1 85  ? 7.46083   12.94745  9.61763   1.000 8.71067  ? 87  LEU B CB  1 
ATOM   2924 C CG  . LEU B 1 85  ? 7.14179   14.25727  10.33367  1.000 8.73608  ? 87  LEU B CG  1 
ATOM   2925 C CD1 . LEU B 1 85  ? 7.83856   14.30599  11.68282  1.000 13.31691 ? 87  LEU B CD1 1 
ATOM   2926 C CD2 . LEU B 1 85  ? 7.57010   15.41376  9.46912   1.000 7.36428  ? 87  LEU B CD2 1 
ATOM   2927 N N   . LYS B 1 86  ? 4.75589   11.97482  11.37614  1.000 7.59755  ? 88  LYS B N   1 
ATOM   2928 C CA  . LYS B 1 86  ? 3.31807   12.14345  11.57806  1.000 9.47804  ? 88  LYS B CA  1 
ATOM   2929 C C   . LYS B 1 86  ? 3.05619   13.54397  12.09693  1.000 14.98459 ? 88  LYS B C   1 
ATOM   2930 O O   . LYS B 1 86  ? 3.54642   13.91605  13.16850  1.000 16.29279 ? 88  LYS B O   1 
ATOM   2931 C CB  . LYS B 1 86  ? 2.76534   11.12489  12.56509  1.000 11.41567 ? 88  LYS B CB  1 
ATOM   2932 C CG  . LYS B 1 86  ? 2.70898   9.72503   12.02851  1.000 12.73778 ? 88  LYS B CG  1 
ATOM   2933 C CD  . LYS B 1 86  ? 2.79962   8.74600   13.16705  1.000 13.15578 ? 88  LYS B CD  1 
ATOM   2934 C CE  . LYS B 1 86  ? 1.65737   7.77534   13.15003  1.000 15.59364 ? 88  LYS B CE  1 
ATOM   2935 N NZ  . LYS B 1 86  ? 1.91895   6.75983   14.20603  1.000 26.50145 ? 88  LYS B NZ  1 
ATOM   2936 N N   . LEU B 1 87  ? 2.29917   14.31491  11.34059  1.000 8.19557  ? 89  LEU B N   1 
ATOM   2937 C CA  . LEU B 1 87  ? 1.96703   15.68187  11.69772  1.000 9.79295  ? 89  LEU B CA  1 
ATOM   2938 C C   . LEU B 1 87  ? 0.49758   15.72140  12.07807  1.000 11.51124 ? 89  LEU B C   1 
ATOM   2939 O O   . LEU B 1 87  ? -0.36463  15.43913  11.24098  1.000 13.56009 ? 89  LEU B O   1 
ATOM   2940 C CB  . LEU B 1 87  ? 2.25731   16.62856  10.53701  1.000 13.35985 ? 89  LEU B CB  1 
ATOM   2941 C CG  . LEU B 1 87  ? 3.72954   16.62738  10.10711  1.000 12.75429 ? 89  LEU B CG  1 
ATOM   2942 C CD1 . LEU B 1 87  ? 3.94033   17.40443  8.82079   1.000 8.96636  ? 89  LEU B CD1 1 
ATOM   2943 C CD2 . LEU B 1 87  ? 4.58599   17.17582  11.23264  1.000 10.18947 ? 89  LEU B CD2 1 
ATOM   2944 N N   . LYS B 1 88  ? 0.21684   16.03568  13.34354  1.000 13.47300 ? 90  LYS B N   1 
ATOM   2945 C CA  . LYS B 1 88  ? -1.16077  16.17075  13.80178  1.000 18.79136 ? 90  LYS B CA  1 
ATOM   2946 C C   . LYS B 1 88  ? -1.68938  17.54624  13.42901  1.000 15.95161 ? 90  LYS B C   1 
ATOM   2947 O O   . LYS B 1 88  ? -1.03563  18.56049  13.68642  1.000 12.68343 ? 90  LYS B O   1 
ATOM   2948 C CB  . LYS B 1 88  ? -1.26350  15.95947  15.31173  1.000 13.67467 ? 90  LYS B CB  1 
ATOM   2949 C CG  . LYS B 1 88  ? -2.68970  15.67321  15.78488  1.000 14.94616 ? 90  LYS B CG  1 
ATOM   2950 C CD  . LYS B 1 88  ? -3.07046  14.20743  15.58501  1.000 17.91906 ? 90  LYS B CD  1 
ATOM   2951 C CE  . LYS B 1 88  ? -4.17557  13.78847  16.55617  1.000 19.96005 ? 90  LYS B CE  1 
ATOM   2952 N NZ  . LYS B 1 88  ? -4.64849  12.38170  16.33356  1.000 19.12793 ? 90  LYS B NZ  1 
ATOM   2953 N N   . VAL B 1 89  ? -2.87220  17.57800  12.81669  1.000 11.17114 ? 91  VAL B N   1 
ATOM   2954 C CA  . VAL B 1 89  ? -3.47316  18.82209  12.35765  1.000 15.73032 ? 91  VAL B CA  1 
ATOM   2955 C C   . VAL B 1 89  ? -4.82625  19.00620  13.04995  1.000 16.43572 ? 91  VAL B C   1 
ATOM   2956 O O   . VAL B 1 89  ? -5.40708  18.06471  13.59676  1.000 13.57525 ? 91  VAL B O   1 
ATOM   2957 C CB  . VAL B 1 89  ? -3.60862  18.84154  10.81847  1.000 13.91993 ? 91  VAL B CB  1 
ATOM   2958 C CG1 . VAL B 1 89  ? -2.25840  18.70122  10.18455  1.000 12.86462 ? 91  VAL B CG1 1 
ATOM   2959 C CG2 . VAL B 1 89  ? -4.50778  17.71574  10.35152  1.000 13.64422 ? 91  VAL B CG2 1 
ATOM   2960 N N   . ASP B 1 90  ? -5.32172  20.24648  13.04145  1.000 16.54771 ? 92  ASP B N   1 
ATOM   2961 C CA  . ASP B 1 90  ? -6.52973  20.55346  13.80654  1.000 20.01849 ? 92  ASP B CA  1 
ATOM   2962 C C   . ASP B 1 90  ? -7.81635  20.16409  13.08994  1.000 25.24837 ? 92  ASP B C   1 
ATOM   2963 O O   . ASP B 1 90  ? -8.89675  20.30274  13.67487  1.000 28.78404 ? 92  ASP B O   1 
ATOM   2964 C CB  . ASP B 1 90  ? -6.58651  22.04475  14.16050  1.000 17.35492 ? 92  ASP B CB  1 
ATOM   2965 C CG  . ASP B 1 90  ? -6.39949  22.95781  12.94572  1.000 36.66663 ? 92  ASP B CG  1 
ATOM   2966 O OD1 . ASP B 1 90  ? -6.34210  22.46638  11.78962  1.000 36.21358 ? 92  ASP B OD1 1 
ATOM   2967 O OD2 . ASP B 1 90  ? -6.30437  24.18780  13.15677  1.000 41.92694 ? 92  ASP B OD2 1 
ATOM   2968 N N   . THR B 1 91  ? -7.73178  19.67492  11.85517  1.000 22.44129 ? 93  THR B N   1 
ATOM   2969 C CA  . THR B 1 91  ? -8.90472  19.38256  11.04419  1.000 19.46277 ? 93  THR B CA  1 
ATOM   2970 C C   . THR B 1 91  ? -8.81635  17.95734  10.51965  1.000 16.69877 ? 93  THR B C   1 
ATOM   2971 O O   . THR B 1 91  ? -7.84343  17.60010  9.84662   1.000 17.14965 ? 93  THR B O   1 
ATOM   2972 C CB  . THR B 1 91  ? -9.01349  20.37525  9.88860   1.000 22.89404 ? 93  THR B CB  1 
ATOM   2973 O OG1 . THR B 1 91  ? -9.11059  21.70237  10.42234  1.000 28.25419 ? 93  THR B OG1 1 
ATOM   2974 C CG2 . THR B 1 91  ? -10.24208 20.06034  9.01453   1.000 24.27393 ? 93  THR B CG2 1 
ATOM   2975 N N   . ALA B 1 92  ? -9.82136  17.14788  10.83473  1.000 13.32921 ? 94  ALA B N   1 
ATOM   2976 C CA  . ALA B 1 92  ? -9.96474  15.84891  10.19728  1.000 18.10900 ? 94  ALA B CA  1 
ATOM   2977 C C   . ALA B 1 92  ? -10.25454 16.01940  8.70369   1.000 21.33505 ? 94  ALA B C   1 
ATOM   2978 O O   . ALA B 1 92  ? -10.92216 16.97130  8.28608   1.000 17.44637 ? 94  ALA B O   1 
ATOM   2979 C CB  . ALA B 1 92  ? -11.08603 15.05655  10.86884  1.000 12.21903 ? 94  ALA B CB  1 
ATOM   2980 N N   . ASN B 1 93  ? -9.73929  15.09323  7.88841   1.000 13.96545 ? 95  ASN B N   1 
ATOM   2981 C CA  . ASN B 1 93  ? -9.99260  15.16704  6.45533   1.000 11.84893 ? 95  ASN B CA  1 
ATOM   2982 C C   . ASN B 1 93  ? -11.41300 14.69494  6.15877   1.000 10.31049 ? 95  ASN B C   1 
ATOM   2983 O O   . ASN B 1 93  ? -11.72685 13.51671  6.36721   1.000 12.49762 ? 95  ASN B O   1 
ATOM   2984 C CB  . ASN B 1 93  ? -8.97635  14.32689  5.68176   1.000 10.41100 ? 95  ASN B CB  1 
ATOM   2985 C CG  . ASN B 1 93  ? -9.10999  14.48978  4.16979   1.000 12.86726 ? 95  ASN B CG  1 
ATOM   2986 O OD1 . ASN B 1 93  ? -10.02829 15.14920  3.67635   1.000 10.89721 ? 95  ASN B OD1 1 
ATOM   2987 N ND2 . ASN B 1 93  ? -8.18775  13.87671  3.42784   1.000 9.03642  ? 95  ASN B ND2 1 
ATOM   2988 N N   . PRO B 1 94  ? -12.29700 15.56861  5.66598   1.000 9.73988  ? 96  PRO B N   1 
ATOM   2989 C CA  . PRO B 1 94  ? -13.66745 15.12616  5.35621   1.000 13.95359 ? 96  PRO B CA  1 
ATOM   2990 C C   . PRO B 1 94  ? -13.73458 14.12217  4.22068   1.000 11.52725 ? 96  PRO B C   1 
ATOM   2991 O O   . PRO B 1 94  ? -14.77061 13.46851  4.05901   1.000 16.53185 ? 96  PRO B O   1 
ATOM   2992 C CB  . PRO B 1 94  ? -14.38739 16.42882  4.99661   1.000 12.98304 ? 96  PRO B CB  1 
ATOM   2993 C CG  . PRO B 1 94  ? -13.30939 17.33568  4.52987   1.000 16.02556 ? 96  PRO B CG  1 
ATOM   2994 C CD  . PRO B 1 94  ? -12.07476 16.97684  5.30885   1.000 12.16907 ? 96  PRO B CD  1 
ATOM   2995 N N   . LYS B 1 95  ? -12.65833 13.95737  3.45463   1.000 10.85121 ? 97  LYS B N   1 
ATOM   2996 C CA  . LYS B 1 95  ? -12.60126 13.00819  2.35539   1.000 14.21113 ? 97  LYS B CA  1 
ATOM   2997 C C   . LYS B 1 95  ? -11.85259 11.73645  2.71951   1.000 13.43292 ? 97  LYS B C   1 
ATOM   2998 O O   . LYS B 1 95  ? -11.42742 11.00587  1.82363   1.000 12.99807 ? 97  LYS B O   1 
ATOM   2999 C CB  . LYS B 1 95  ? -11.95221 13.65472  1.13081   1.000 11.85942 ? 97  LYS B CB  1 
ATOM   3000 C CG  . LYS B 1 95  ? -12.83660 14.66750  0.42559   1.000 12.42074 ? 97  LYS B CG  1 
ATOM   3001 C CD  . LYS B 1 95  ? -11.98824 15.62156  -0.38621  1.000 18.30119 ? 97  LYS B CD  1 
ATOM   3002 C CE  . LYS B 1 95  ? -12.84893 16.60287  -1.17256  1.000 27.59032 ? 97  LYS B CE  1 
ATOM   3003 N NZ  . LYS B 1 95  ? -12.01085 17.51421  -2.00901  1.000 38.76360 ? 97  LYS B NZ  1 
ATOM   3004 N N   . THR B 1 96  ? -11.67106 11.45360  4.00052   1.000 12.16704 ? 98  THR B N   1 
ATOM   3005 C CA  . THR B 1 96  ? -10.94974 10.24056  4.36677   1.000 12.29133 ? 98  THR B CA  1 
ATOM   3006 C C   . THR B 1 96  ? -11.77198 9.01935   3.95931   1.000 9.50861  ? 98  THR B C   1 
ATOM   3007 O O   . THR B 1 96  ? -12.94458 8.91975   4.33132   1.000 8.88997  ? 98  THR B O   1 
ATOM   3008 C CB  . THR B 1 96  ? -10.65642 10.21151  5.86863   1.000 14.08132 ? 98  THR B CB  1 
ATOM   3009 O OG1 . THR B 1 96  ? -10.04833 11.44794  6.26708   1.000 13.79627 ? 98  THR B OG1 1 
ATOM   3010 C CG2 . THR B 1 96  ? -9.72108  9.07303   6.19638   1.000 11.30073 ? 98  THR B CG2 1 
ATOM   3011 N N   . PRO B 1 97  ? -11.20857 8.08676   3.19495   1.000 11.00316 ? 99  PRO B N   1 
ATOM   3012 C CA  . PRO B 1 97  ? -11.93314 6.85397   2.85970   1.000 8.73673  ? 99  PRO B CA  1 
ATOM   3013 C C   . PRO B 1 97  ? -11.80270 5.81136   3.96000   1.000 9.21227  ? 99  PRO B C   1 
ATOM   3014 O O   . PRO B 1 97  ? -10.99838 5.94139   4.88875   1.000 9.42543  ? 99  PRO B O   1 
ATOM   3015 C CB  . PRO B 1 97  ? -11.22561 6.37946   1.58814   1.000 10.65215 ? 99  PRO B CB  1 
ATOM   3016 C CG  . PRO B 1 97  ? -9.81535  6.80890   1.79651   1.000 6.77464  ? 99  PRO B CG  1 
ATOM   3017 C CD  . PRO B 1 97  ? -9.89668  8.15157   2.52369   1.000 8.83506  ? 99  PRO B CD  1 
ATOM   3018 N N   . LYS B 1 98  ? -12.59616 4.74539   3.83022   1.000 5.23987  ? 100 LYS B N   1 
ATOM   3019 C CA  . LYS B 1 98  ? -12.27195 3.51773   4.55380   1.000 11.15802 ? 100 LYS B CA  1 
ATOM   3020 C C   . LYS B 1 98  ? -10.90053 3.02534   4.09554   1.000 8.77074  ? 100 LYS B C   1 
ATOM   3021 O O   . LYS B 1 98  ? -10.66526 2.85033   2.89467   1.000 6.20916  ? 100 LYS B O   1 
ATOM   3022 C CB  . LYS B 1 98  ? -13.32815 2.43048   4.31350   1.000 5.01667  ? 100 LYS B CB  1 
ATOM   3023 N N   . TYR B 1 99  ? -9.99359  2.80139   5.04635   1.000 10.34063 ? 101 TYR B N   1 
ATOM   3024 C CA  . TYR B 1 99  ? -8.63049  2.41338   4.69039   1.000 12.41546 ? 101 TYR B CA  1 
ATOM   3025 C C   . TYR B 1 99  ? -8.05491  1.46068   5.73122   1.000 13.90965 ? 101 TYR B C   1 
ATOM   3026 O O   . TYR B 1 99  ? -8.55631  1.35868   6.85724   1.000 8.16348  ? 101 TYR B O   1 
ATOM   3027 C CB  . TYR B 1 99  ? -7.71934  3.64652   4.52731   1.000 8.11065  ? 101 TYR B CB  1 
ATOM   3028 C CG  . TYR B 1 99  ? -7.30682  4.29458   5.83532   1.000 10.68961 ? 101 TYR B CG  1 
ATOM   3029 C CD1 . TYR B 1 99  ? -8.13033  5.22182   6.47559   1.000 8.57827  ? 101 TYR B CD1 1 
ATOM   3030 C CD2 . TYR B 1 99  ? -6.09607  3.97636   6.43500   1.000 8.39075  ? 101 TYR B CD2 1 
ATOM   3031 C CE1 . TYR B 1 99  ? -7.75059  5.80782   7.68800   1.000 9.41820  ? 101 TYR B CE1 1 
ATOM   3032 C CE2 . TYR B 1 99  ? -5.71416  4.55064   7.63471   1.000 9.14407  ? 101 TYR B CE2 1 
ATOM   3033 C CZ  . TYR B 1 99  ? -6.53335  5.46832   8.25520   1.000 12.30228 ? 101 TYR B CZ  1 
ATOM   3034 O OH  . TYR B 1 99  ? -6.12548  6.02674   9.45618   1.000 10.37250 ? 101 TYR B OH  1 
ATOM   3035 N N   . LYS B 1 100 ? -6.99677  0.74672   5.31434   1.000 11.62414 ? 102 LYS B N   1 
ATOM   3036 C CA  . LYS B 1 100 ? -6.09906  -0.00690  6.18555   1.000 9.49109  ? 102 LYS B CA  1 
ATOM   3037 C C   . LYS B 1 100 ? -4.65447  0.20548   5.73527   1.000 8.78354  ? 102 LYS B C   1 
ATOM   3038 O O   . LYS B 1 100 ? -4.37865  0.42265   4.55301   1.000 5.50650  ? 102 LYS B O   1 
ATOM   3039 C CB  . LYS B 1 100 ? -6.37278  -1.51655  6.17701   1.000 12.29789 ? 102 LYS B CB  1 
ATOM   3040 C CG  . LYS B 1 100 ? -7.83565  -1.90096  6.34708   1.000 22.33593 ? 102 LYS B CG  1 
ATOM   3041 C CD  . LYS B 1 100 ? -7.99345  -3.41126  6.48288   1.000 22.51326 ? 102 LYS B CD  1 
ATOM   3042 C CE  . LYS B 1 100 ? -7.35831  -4.13613  5.30536   1.000 23.55980 ? 102 LYS B CE  1 
ATOM   3043 N NZ  . LYS B 1 100 ? -8.16383  -3.96109  4.06300   1.000 36.29572 ? 102 LYS B NZ  1 
ATOM   3044 N N   . PHE B 1 101 ? -3.73441  0.13015   6.69032   1.000 5.98438  ? 103 PHE B N   1 
ATOM   3045 C CA  . PHE B 1 101 ? -2.30339  0.05601   6.39628   1.000 6.04387  ? 103 PHE B CA  1 
ATOM   3046 C C   . PHE B 1 101 ? -1.90877  -1.41635  6.27536   1.000 7.26031  ? 103 PHE B C   1 
ATOM   3047 O O   . PHE B 1 101 ? -2.13131  -2.19275  7.20841   1.000 8.43741  ? 103 PHE B O   1 
ATOM   3048 C CB  . PHE B 1 101 ? -1.49386  0.73834   7.50342   1.000 7.51985  ? 103 PHE B CB  1 
ATOM   3049 C CG  . PHE B 1 101 ? -1.59066  2.25007   7.51032   1.000 6.68651  ? 103 PHE B CG  1 
ATOM   3050 C CD1 . PHE B 1 101 ? -2.16275  2.93872   6.44096   1.000 3.32310  ? 103 PHE B CD1 1 
ATOM   3051 C CD2 . PHE B 1 101 ? -1.08907  2.98065   8.58952   1.000 3.49632  ? 103 PHE B CD2 1 
ATOM   3052 C CE1 . PHE B 1 101 ? -2.25476  4.31480   6.45473   1.000 3.07385  ? 103 PHE B CE1 1 
ATOM   3053 C CE2 . PHE B 1 101 ? -1.16415  4.35886   8.61052   1.000 4.01149  ? 103 PHE B CE2 1 
ATOM   3054 C CZ  . PHE B 1 101 ? -1.74453  5.03538   7.54712   1.000 7.57463  ? 103 PHE B CZ  1 
ATOM   3055 N N   . VAL B 1 102 ? -1.33113  -1.81456  5.13668   1.000 5.05840  ? 104 VAL B N   1 
ATOM   3056 C CA  . VAL B 1 102 ? -0.92687  -3.20350  4.94797   1.000 3.66265  ? 104 VAL B CA  1 
ATOM   3057 C C   . VAL B 1 102 ? 0.51533   -3.25379  4.45083   1.000 5.64971  ? 104 VAL B C   1 
ATOM   3058 O O   . VAL B 1 102 ? 1.04787   -2.28659  3.90143   1.000 8.17536  ? 104 VAL B O   1 
ATOM   3059 C CB  . VAL B 1 102 ? -1.86934  -3.97402  3.98581   1.000 8.36934  ? 104 VAL B CB  1 
ATOM   3060 C CG1 . VAL B 1 102 ? -3.35489  -3.75563  4.38089   1.000 6.76786  ? 104 VAL B CG1 1 
ATOM   3061 C CG2 . VAL B 1 102 ? -1.63119  -3.57610  2.54655   1.000 5.21332  ? 104 VAL B CG2 1 
ATOM   3062 N N   . ARG B 1 103 ? 1.16152   -4.39730  4.65983   1.000 3.61377  ? 105 ARG B N   1 
ATOM   3063 C CA  . ARG B 1 103 ? 2.52779   -4.60663  4.17877   1.000 7.40729  ? 105 ARG B CA  1 
ATOM   3064 C C   . ARG B 1 103 ? 2.52487   -5.74788  3.17210   1.000 4.65524  ? 105 ARG B C   1 
ATOM   3065 O O   . ARG B 1 103 ? 2.11018   -6.86090  3.49969   1.000 10.28434 ? 105 ARG B O   1 
ATOM   3066 C CB  . ARG B 1 103 ? 3.48873   -4.88856  5.34423   1.000 6.45260  ? 105 ARG B CB  1 
ATOM   3067 C CG  . ARG B 1 103 ? 4.97195   -5.00283  4.91976   1.000 5.52614  ? 105 ARG B CG  1 
ATOM   3068 C CD  . ARG B 1 103 ? 5.93938   -5.12927  6.10156   1.000 7.45449  ? 105 ARG B CD  1 
ATOM   3069 N NE  . ARG B 1 103 ? 7.33300   -5.33766  5.65630   1.000 5.72483  ? 105 ARG B NE  1 
ATOM   3070 C CZ  . ARG B 1 103 ? 8.17578   -4.35075  5.36243   1.000 5.32002  ? 105 ARG B CZ  1 
ATOM   3071 N NH1 . ARG B 1 103 ? 7.77411   -3.09429  5.46251   1.000 6.33377  ? 105 ARG B NH1 1 
ATOM   3072 N NH2 . ARG B 1 103 ? 9.42578   -4.61231  4.96828   1.000 4.50314  ? 105 ARG B NH2 1 
ATOM   3073 N N   . ILE B 1 104 ? 2.97939   -5.48236  1.94932   1.000 4.03155  ? 106 ILE B N   1 
ATOM   3074 C CA  . ILE B 1 104 ? 2.83642   -6.50200  0.91156   1.000 9.26526  ? 106 ILE B CA  1 
ATOM   3075 C C   . ILE B 1 104 ? 4.08468   -7.36107  0.78343   1.000 12.18545 ? 106 ILE B C   1 
ATOM   3076 O O   . ILE B 1 104 ? 5.13662   -7.05463  1.35350   1.000 4.98223  ? 106 ILE B O   1 
ATOM   3077 C CB  . ILE B 1 104 ? 2.48873   -5.88113  -0.45040  1.000 12.38837 ? 106 ILE B CB  1 
ATOM   3078 C CG1 . ILE B 1 104 ? 3.43746   -4.72813  -0.75554  1.000 8.67699  ? 106 ILE B CG1 1 
ATOM   3079 C CG2 . ILE B 1 104 ? 1.00499   -5.48643  -0.49738  1.000 8.39263  ? 106 ILE B CG2 1 
ATOM   3080 C CD1 . ILE B 1 104 ? 3.30754   -4.23413  -2.14597  1.000 8.70644  ? 106 ILE B CD1 1 
ATOM   3081 N N   . GLN B 1 105 ? 3.96367   -8.44682  0.03853   1.000 16.28336 ? 107 GLN B N   1 
ATOM   3082 C CA  . GLN B 1 105 ? 4.98770   -9.42858  -0.24912  1.000 14.59521 ? 107 GLN B CA  1 
ATOM   3083 C C   . GLN B 1 105 ? 5.56878   -9.19419  -1.63636  1.000 11.12992 ? 107 GLN B C   1 
ATOM   3084 O O   . GLN B 1 105 ? 4.85673   -8.74729  -2.54268  1.000 12.53575 ? 107 GLN B O   1 
ATOM   3085 C CB  . GLN B 1 105 ? 4.40712   -10.84489 -0.18326  1.000 16.61847 ? 107 GLN B CB  1 
ATOM   3086 C CG  . GLN B 1 105 ? 3.82074   -11.23191 1.15846   1.000 22.37793 ? 107 GLN B CG  1 
ATOM   3087 C CD  . GLN B 1 105 ? 4.83960   -11.15879 2.27143   1.000 24.70562 ? 107 GLN B CD  1 
ATOM   3088 O OE1 . GLN B 1 105 ? 5.98995   -11.58841 2.11696   1.000 30.73362 ? 107 GLN B OE1 1 
ATOM   3089 N NE2 . GLN B 1 105 ? 4.42676   -10.60631 3.40591   1.000 32.59584 ? 107 GLN B NE2 1 
ATOM   3090 N N   . PRO B 1 106 ? 6.86019   -9.47208  -1.81770  1.000 12.47076 ? 108 PRO B N   1 
ATOM   3091 C CA  . PRO B 1 106 ? 7.43591   -9.45806  -3.16802  1.000 8.21800  ? 108 PRO B CA  1 
ATOM   3092 C C   . PRO B 1 106 ? 6.55578   -10.23360 -4.13683  1.000 12.84064 ? 108 PRO B C   1 
ATOM   3093 O O   . PRO B 1 106 ? 6.03039   -11.30109 -3.81281  1.000 9.81283  ? 108 PRO B O   1 
ATOM   3094 C CB  . PRO B 1 106 ? 8.79243   -10.13843 -2.98375  1.000 12.31650 ? 108 PRO B CB  1 
ATOM   3095 C CG  . PRO B 1 106 ? 9.15233   -9.85806  -1.53975  1.000 11.51981 ? 108 PRO B CG  1 
ATOM   3096 C CD  . PRO B 1 106 ? 7.85502   -9.81194  -0.78140  1.000 10.57591 ? 108 PRO B CD  1 
ATOM   3097 N N   . GLY B 1 107 ? 6.39480   -9.68524  -5.33470  1.000 11.91778 ? 109 GLY B N   1 
ATOM   3098 C CA  . GLY B 1 107 ? 5.53692   -10.28064 -6.32876  1.000 12.34576 ? 109 GLY B CA  1 
ATOM   3099 C C   . GLY B 1 107 ? 4.12319   -9.74544  -6.34879  1.000 14.69677 ? 109 GLY B C   1 
ATOM   3100 O O   . GLY B 1 107 ? 3.39525   -10.00402 -7.31859  1.000 11.89328 ? 109 GLY B O   1 
ATOM   3101 N N   . GLN B 1 108 ? 3.70663   -9.01598  -5.31465  1.000 11.62089 ? 110 GLN B N   1 
ATOM   3102 C CA  . GLN B 1 108 ? 2.37649   -8.42532  -5.27543  1.000 11.62960 ? 110 GLN B CA  1 
ATOM   3103 C C   . GLN B 1 108 ? 2.38944   -7.06854  -5.96632  1.000 11.05866 ? 110 GLN B C   1 
ATOM   3104 O O   . GLN B 1 108 ? 3.40109   -6.36611  -5.98207  1.000 9.71038  ? 110 GLN B O   1 
ATOM   3105 C CB  . GLN B 1 108 ? 1.88404   -8.27377  -3.83378  1.000 9.60310  ? 110 GLN B CB  1 
ATOM   3106 C CG  . GLN B 1 108 ? 1.65865   -9.59940  -3.10795  1.000 12.92378 ? 110 GLN B CG  1 
ATOM   3107 C CD  . GLN B 1 108 ? 0.87759   -9.42909  -1.79961  1.000 22.05777 ? 110 GLN B CD  1 
ATOM   3108 O OE1 . GLN B 1 108 ? 1.44902   -9.46707  -0.70451  1.000 26.36188 ? 110 GLN B OE1 1 
ATOM   3109 N NE2 . GLN B 1 108 ? -0.43775  -9.24381  -1.91345  1.000 34.12418 ? 110 GLN B NE2 1 
ATOM   3110 N N   . THR B 1 109 ? 1.25435   -6.70431  -6.54620  1.000 9.04955  ? 111 THR B N   1 
ATOM   3111 C CA  . THR B 1 109 ? 1.16112   -5.48092  -7.32836  1.000 8.59844  ? 111 THR B CA  1 
ATOM   3112 C C   . THR B 1 109 ? 0.36123   -4.43403  -6.56795  1.000 7.39965  ? 111 THR B C   1 
ATOM   3113 O O   . THR B 1 109 ? -0.39046  -4.74823  -5.64323  1.000 9.20450  ? 111 THR B O   1 
ATOM   3114 C CB  . THR B 1 109 ? 0.51305   -5.74381  -8.69566  1.000 9.44459  ? 111 THR B CB  1 
ATOM   3115 O OG1 . THR B 1 109 ? -0.75463  -6.39269  -8.51448  1.000 7.03844  ? 111 THR B OG1 1 
ATOM   3116 C CG2 . THR B 1 109 ? 1.43055   -6.61042  -9.55178  1.000 10.31977 ? 111 THR B CG2 1 
ATOM   3117 N N   . PHE B 1 110 ? 0.53014   -3.17893  -6.97105  1.000 6.67534  ? 112 PHE B N   1 
ATOM   3118 C CA  . PHE B 1 110 ? -0.28190  -2.10820  -6.41556  1.000 6.62313  ? 112 PHE B CA  1 
ATOM   3119 C C   . PHE B 1 110 ? -0.29818  -0.94689  -7.39464  1.000 7.12055  ? 112 PHE B C   1 
ATOM   3120 O O   . PHE B 1 110 ? 0.53677   -0.86709  -8.30062  1.000 9.88561  ? 112 PHE B O   1 
ATOM   3121 C CB  . PHE B 1 110 ? 0.24423   -1.65778  -5.04868  1.000 3.90990  ? 112 PHE B CB  1 
ATOM   3122 C CG  . PHE B 1 110 ? 1.72940   -1.36746  -5.02348  1.000 4.19691  ? 112 PHE B CG  1 
ATOM   3123 C CD1 . PHE B 1 110 ? 2.64441   -2.38920  -4.86563  1.000 6.56505  ? 112 PHE B CD1 1 
ATOM   3124 C CD2 . PHE B 1 110 ? 2.19824   -0.07366  -5.13028  1.000 3.47460  ? 112 PHE B CD2 1 
ATOM   3125 C CE1 . PHE B 1 110 ? 4.01527   -2.12395  -4.81813  1.000 9.15872  ? 112 PHE B CE1 1 
ATOM   3126 C CE2 . PHE B 1 110 ? 3.56115   0.20930   -5.07308  1.000 10.26838 ? 112 PHE B CE2 1 
ATOM   3127 C CZ  . PHE B 1 110 ? 4.47506   -0.82343  -4.92283  1.000 7.44871  ? 112 PHE B CZ  1 
ATOM   3128 N N   . SER B 1 111 ? -1.23509  -0.02774  -7.17529  1.000 4.49417  ? 113 SER B N   1 
ATOM   3129 C CA  . SER B 1 111 ? -1.29967  1.20622   -7.94508  1.000 3.74679  ? 113 SER B CA  1 
ATOM   3130 C C   . SER B 1 111 ? -0.57043  2.32413   -7.21803  1.000 5.09292  ? 113 SER B C   1 
ATOM   3131 O O   . SER B 1 111 ? -0.61687  2.41825   -5.99043  1.000 5.70460  ? 113 SER B O   1 
ATOM   3132 C CB  . SER B 1 111 ? -2.74848  1.63272   -8.18687  1.000 4.87958  ? 113 SER B CB  1 
ATOM   3133 O OG  . SER B 1 111 ? -3.39928  0.71622   -9.02930  1.000 6.29931  ? 113 SER B OG  1 
ATOM   3134 N N   . VAL B 1 112 ? 0.06044   3.19654   -7.99359  1.000 3.76203  ? 114 VAL B N   1 
ATOM   3135 C CA  . VAL B 1 112 ? 0.83301   4.31921   -7.49186  1.000 4.51883  ? 114 VAL B CA  1 
ATOM   3136 C C   . VAL B 1 112 ? 0.18782   5.60581   -7.99777  1.000 4.71247  ? 114 VAL B C   1 
ATOM   3137 O O   . VAL B 1 112 ? -0.08569  5.73996   -9.19606  1.000 5.20331  ? 114 VAL B O   1 
ATOM   3138 C CB  . VAL B 1 112 ? 2.29992   4.22561   -7.96126  1.000 4.25894  ? 114 VAL B CB  1 
ATOM   3139 C CG1 . VAL B 1 112 ? 3.00533   5.56338   -7.79727  1.000 6.66647  ? 114 VAL B CG1 1 
ATOM   3140 C CG2 . VAL B 1 112 ? 3.02892   3.12349   -7.21617  1.000 5.56323  ? 114 VAL B CG2 1 
ATOM   3141 N N   . LEU B 1 113 ? -0.00424  6.56482   -7.10566  1.000 2.60086  ? 115 LEU B N   1 
ATOM   3142 C CA  . LEU B 1 113 ? -0.47606  7.89582   -7.46881  1.000 2.46191  ? 115 LEU B CA  1 
ATOM   3143 C C   . LEU B 1 113 ? 0.68135   8.88894   -7.29724  1.000 9.00418  ? 115 LEU B C   1 
ATOM   3144 O O   . LEU B 1 113 ? 0.88819   9.45808   -6.21606  1.000 5.89537  ? 115 LEU B O   1 
ATOM   3145 C CB  . LEU B 1 113 ? -1.69933  8.26980   -6.61891  1.000 7.19778  ? 115 LEU B CB  1 
ATOM   3146 C CG  . LEU B 1 113 ? -2.35338  9.59330   -6.99694  1.000 6.49755  ? 115 LEU B CG  1 
ATOM   3147 C CD1 . LEU B 1 113 ? -3.01840  9.47366   -8.37387  1.000 3.55393  ? 115 LEU B CD1 1 
ATOM   3148 C CD2 . LEU B 1 113 ? -3.31710  10.01422  -5.93084  1.000 1.72797  ? 115 LEU B CD2 1 
ATOM   3149 N N   . ALA B 1 114 ? 1.43533   9.10356   -8.38209  1.000 6.76916  ? 116 ALA B N   1 
ATOM   3150 C CA  . ALA B 1 114 ? 2.55575   10.04575  -8.35431  1.000 9.85595  ? 116 ALA B CA  1 
ATOM   3151 C C   . ALA B 1 114 ? 2.06142   11.48844  -8.20776  1.000 9.91411  ? 116 ALA B C   1 
ATOM   3152 O O   . ALA B 1 114 ? 1.14054   11.91589  -8.91352  1.000 13.38669 ? 116 ALA B O   1 
ATOM   3153 C CB  . ALA B 1 114 ? 3.39805   9.89798   -9.62122  1.000 11.42686 ? 116 ALA B CB  1 
ATOM   3154 N N   . CYS B 1 115 ? 2.67848   12.24448  -7.29231  1.000 10.85399 ? 117 CYS B N   1 
ATOM   3155 C CA  . CYS B 1 115 ? 2.24776   13.60448  -6.98500  1.000 10.25655 ? 117 CYS B CA  1 
ATOM   3156 C C   . CYS B 1 115 ? 3.45547   14.52625  -6.89065  1.000 13.58067 ? 117 CYS B C   1 
ATOM   3157 O O   . CYS B 1 115 ? 4.58058   14.08986  -6.63065  1.000 11.56426 ? 117 CYS B O   1 
ATOM   3158 C CB  . CYS B 1 115 ? 1.45096   13.67529  -5.66912  1.000 10.99954 ? 117 CYS B CB  1 
ATOM   3159 S SG  . CYS B 1 115 ? 0.02911   12.57913  -5.56830  1.000 12.40644 ? 117 CYS B SG  1 
ATOM   3160 N N   . TYR B 1 116 ? 3.21568   15.81712  -7.12322  1.000 11.88737 ? 118 TYR B N   1 
ATOM   3161 C CA  . TYR B 1 116 ? 4.26310   16.82350  -6.97437  1.000 8.85700  ? 118 TYR B CA  1 
ATOM   3162 C C   . TYR B 1 116 ? 3.64560   18.05544  -6.33432  1.000 11.90807 ? 118 TYR B C   1 
ATOM   3163 O O   . TYR B 1 116 ? 2.59115   18.52157  -6.77422  1.000 12.63527 ? 118 TYR B O   1 
ATOM   3164 C CB  . TYR B 1 116 ? 4.92020   17.14633  -8.32508  1.000 10.94975 ? 118 TYR B CB  1 
ATOM   3165 C CG  . TYR B 1 116 ? 5.55246   15.90497  -8.91456  1.000 15.13592 ? 118 TYR B CG  1 
ATOM   3166 C CD1 . TYR B 1 116 ? 6.83332   15.50002  -8.53559  1.000 12.42164 ? 118 TYR B CD1 1 
ATOM   3167 C CD2 . TYR B 1 116 ? 4.84385   15.09337  -9.79683  1.000 12.65883 ? 118 TYR B CD2 1 
ATOM   3168 C CE1 . TYR B 1 116 ? 7.39987   14.33421  -9.04866  1.000 12.23228 ? 118 TYR B CE1 1 
ATOM   3169 C CE2 . TYR B 1 116 ? 5.40091   13.92740  -10.30846 1.000 12.29141 ? 118 TYR B CE2 1 
ATOM   3170 C CZ  . TYR B 1 116 ? 6.66902   13.55165  -9.92975  1.000 8.70322  ? 118 TYR B CZ  1 
ATOM   3171 O OH  . TYR B 1 116 ? 7.20016   12.39291  -10.43920 1.000 10.41436 ? 118 TYR B OH  1 
ATOM   3172 N N   . ASN B 1 117 ? 4.27395   18.54609  -5.26142  1.000 13.39157 ? 119 ASN B N   1 
ATOM   3173 C CA  . ASN B 1 117 ? 3.75160   19.68395  -4.49607  1.000 12.24651 ? 119 ASN B CA  1 
ATOM   3174 C C   . ASN B 1 117 ? 2.34837   19.39421  -3.95549  1.000 14.53175 ? 119 ASN B C   1 
ATOM   3175 O O   . ASN B 1 117 ? 1.47262   20.26067  -3.95668  1.000 12.77328 ? 119 ASN B O   1 
ATOM   3176 C CB  . ASN B 1 117 ? 3.75201   20.96218  -5.34407  1.000 16.32829 ? 119 ASN B CB  1 
ATOM   3177 C CG  . ASN B 1 117 ? 5.13058   21.29537  -5.90973  1.000 24.85742 ? 119 ASN B CG  1 
ATOM   3178 O OD1 . ASN B 1 117 ? 6.10841   21.39828  -5.17022  1.000 23.50912 ? 119 ASN B OD1 1 
ATOM   3179 N ND2 . ASN B 1 117 ? 5.20919   21.46013  -7.22958  1.000 27.18470 ? 119 ASN B ND2 1 
ATOM   3180 N N   . GLY B 1 118 ? 2.12006   18.15479  -3.52108  1.000 12.80998 ? 120 GLY B N   1 
ATOM   3181 C CA  . GLY B 1 118 ? 0.80360   17.74007  -3.05993  1.000 12.25339 ? 120 GLY B CA  1 
ATOM   3182 C C   . GLY B 1 118 ? -0.24996  17.52521  -4.13224  1.000 14.68785 ? 120 GLY B C   1 
ATOM   3183 O O   . GLY B 1 118 ? -1.39239  17.22754  -3.78832  1.000 9.49700  ? 120 GLY B O   1 
ATOM   3184 N N   . SER B 1 119 ? 0.09931   17.63905  -5.41779  1.000 14.35423 ? 121 SER B N   1 
ATOM   3185 C CA  . SER B 1 119 ? -0.86866  17.62983  -6.51746  1.000 18.70327 ? 121 SER B CA  1 
ATOM   3186 C C   . SER B 1 119 ? -0.79731  16.33537  -7.30975  1.000 12.80773 ? 121 SER B C   1 
ATOM   3187 O O   . SER B 1 119 ? 0.24270   16.05974  -7.92240  1.000 9.24442  ? 121 SER B O   1 
ATOM   3188 C CB  . SER B 1 119 ? -0.61856  18.80778  -7.45137  1.000 19.27404 ? 121 SER B CB  1 
ATOM   3189 O OG  . SER B 1 119 ? -1.16522  19.98575  -6.90889  1.000 32.07426 ? 121 SER B OG  1 
ATOM   3190 N N   . PRO B 1 120 ? -1.87091  15.54525  -7.37173  1.000 13.47009 ? 122 PRO B N   1 
ATOM   3191 C CA  . PRO B 1 120 ? -1.83274  14.30907  -8.16597  1.000 9.49659  ? 122 PRO B CA  1 
ATOM   3192 C C   . PRO B 1 120 ? -1.49344  14.59020  -9.62398  1.000 14.17850 ? 122 PRO B C   1 
ATOM   3193 O O   . PRO B 1 120 ? -2.07122  15.47833  -10.25049 1.000 16.55635 ? 122 PRO B O   1 
ATOM   3194 C CB  . PRO B 1 120 ? -3.24653  13.74647  -8.00460  1.000 11.95571 ? 122 PRO B CB  1 
ATOM   3195 C CG  . PRO B 1 120 ? -3.67299  14.25414  -6.64894  1.000 11.47460 ? 122 PRO B CG  1 
ATOM   3196 C CD  . PRO B 1 120 ? -3.11005  15.65676  -6.58698  1.000 10.03715 ? 122 PRO B CD  1 
ATOM   3197 N N   . SER B 1 121 ? -0.54682  13.81546  -10.15755 1.000 6.95216  ? 123 SER B N   1 
ATOM   3198 C CA  . SER B 1 121 ? -0.00966  13.99427  -11.49802 1.000 8.95063  ? 123 SER B CA  1 
ATOM   3199 C C   . SER B 1 121 ? -0.29406  12.82895  -12.43526 1.000 6.88335  ? 123 SER B C   1 
ATOM   3200 O O   . SER B 1 121 ? -0.54755  13.05555  -13.61281 1.000 8.52068  ? 123 SER B O   1 
ATOM   3201 C CB  . SER B 1 121 ? 1.50726   14.22160  -11.42221 1.000 11.95958 ? 123 SER B CB  1 
ATOM   3202 O OG  . SER B 1 121 ? 1.95926   14.96776  -12.53093 1.000 19.90439 ? 123 SER B OG  1 
ATOM   3203 N N   . GLY B 1 122 ? -0.25821  11.59027  -11.95045 1.000 5.49638  ? 124 GLY B N   1 
ATOM   3204 C CA  . GLY B 1 122 ? -0.53230  10.43242  -12.78296 1.000 4.24725  ? 124 GLY B CA  1 
ATOM   3205 C C   . GLY B 1 122 ? -0.69214  9.20050   -11.92165 1.000 5.38100  ? 124 GLY B C   1 
ATOM   3206 O O   . GLY B 1 122 ? -0.34542  9.20161   -10.73748 1.000 7.23029  ? 124 GLY B O   1 
ATOM   3207 N N   . VAL B 1 123 ? -1.23921  8.14241   -12.52975 1.000 5.57207  ? 125 VAL B N   1 
ATOM   3208 C CA  . VAL B 1 123 ? -1.46364  6.86655   -11.85405 1.000 4.47066  ? 125 VAL B CA  1 
ATOM   3209 C C   . VAL B 1 123 ? -0.95220  5.73433   -12.73942 1.000 9.90602  ? 125 VAL B C   1 
ATOM   3210 O O   . VAL B 1 123 ? -1.07567  5.78698   -13.96786 1.000 9.97215  ? 125 VAL B O   1 
ATOM   3211 C CB  . VAL B 1 123 ? -2.95289  6.66071   -11.47751 1.000 9.09323  ? 125 VAL B CB  1 
ATOM   3212 C CG1 . VAL B 1 123 ? -3.84432  6.65881   -12.71798 1.000 5.69654  ? 125 VAL B CG1 1 
ATOM   3213 C CG2 . VAL B 1 123 ? -3.12568  5.38053   -10.65686 1.000 8.21801  ? 125 VAL B CG2 1 
ATOM   3214 N N   . TYR B 1 124 ? -0.32976  4.73205   -12.12017 1.000 9.79119  ? 126 TYR B N   1 
ATOM   3215 C CA  . TYR B 1 124 ? 0.18251   3.59104   -12.87019 1.000 7.96940  ? 126 TYR B CA  1 
ATOM   3216 C C   . TYR B 1 124 ? 0.28975   2.39527   -11.93987 1.000 6.87435  ? 126 TYR B C   1 
ATOM   3217 O O   . TYR B 1 124 ? 0.22337   2.52177   -10.71576 1.000 9.97006  ? 126 TYR B O   1 
ATOM   3218 C CB  . TYR B 1 124 ? 1.52538   3.90012   -13.53663 1.000 10.97563 ? 126 TYR B CB  1 
ATOM   3219 C CG  . TYR B 1 124 ? 2.61851   4.39643   -12.62229 1.000 11.15668 ? 126 TYR B CG  1 
ATOM   3220 C CD1 . TYR B 1 124 ? 3.44231   3.50899   -11.94485 1.000 8.95742  ? 126 TYR B CD1 1 
ATOM   3221 C CD2 . TYR B 1 124 ? 2.84822   5.75959   -12.46043 1.000 15.33013 ? 126 TYR B CD2 1 
ATOM   3222 C CE1 . TYR B 1 124 ? 4.45561   3.96630   -11.12064 1.000 14.31352 ? 126 TYR B CE1 1 
ATOM   3223 C CE2 . TYR B 1 124 ? 3.86627   6.22780   -11.63308 1.000 13.04709 ? 126 TYR B CE2 1 
ATOM   3224 C CZ  . TYR B 1 124 ? 4.66251   5.32867   -10.96962 1.000 13.34924 ? 126 TYR B CZ  1 
ATOM   3225 O OH  . TYR B 1 124 ? 5.66375   5.79483   -10.15161 1.000 19.22176 ? 126 TYR B OH  1 
ATOM   3226 N N   . GLN B 1 125 ? 0.45419   1.22959   -12.54229 1.000 6.00663  ? 127 GLN B N   1 
ATOM   3227 C CA  . GLN B 1 125 ? 0.48619   -0.03699  -11.82657 1.000 11.51033 ? 127 GLN B CA  1 
ATOM   3228 C C   . GLN B 1 125 ? 1.93407   -0.50110  -11.64855 1.000 11.59424 ? 127 GLN B C   1 
ATOM   3229 O O   . GLN B 1 125 ? 2.74419   -0.39238  -12.57131 1.000 13.75595 ? 127 GLN B O   1 
ATOM   3230 C CB  . GLN B 1 125 ? -0.34415  -1.07720  -12.58986 1.000 11.24248 ? 127 GLN B CB  1 
ATOM   3231 C CG  . GLN B 1 125 ? -0.51285  -2.40211  -11.90185 1.000 11.49784 ? 127 GLN B CG  1 
ATOM   3232 C CD  . GLN B 1 125 ? -1.56851  -2.38813  -10.84057 1.000 10.94467 ? 127 GLN B CD  1 
ATOM   3233 O OE1 . GLN B 1 125 ? -2.05836  -1.32725  -10.42916 1.000 14.87746 ? 127 GLN B OE1 1 
ATOM   3234 N NE2 . GLN B 1 125 ? -1.94534  -3.57614  -10.38274 1.000 16.58577 ? 127 GLN B NE2 1 
ATOM   3235 N N   . CYS B 1 126 ? 2.24839   -1.01023  -10.45063 1.000 8.23336  ? 128 CYS B N   1 
ATOM   3236 C CA  . CYS B 1 126 ? 3.59748   -1.39231  -10.03500 1.000 13.67882 ? 128 CYS B CA  1 
ATOM   3237 C C   . CYS B 1 126 ? 3.58997   -2.78407  -9.42209  1.000 9.41773  ? 128 CYS B C   1 
ATOM   3238 O O   . CYS B 1 126 ? 2.54003   -3.33319  -9.09563  1.000 10.41064 ? 128 CYS B O   1 
ATOM   3239 C CB  . CYS B 1 126 ? 4.16183   -0.42322  -8.98732  1.000 11.82551 ? 128 CYS B CB  1 
ATOM   3240 S SG  . CYS B 1 126 ? 5.22851   0.76747   -9.66308  1.000 34.46371 ? 128 CYS B SG  1 
ATOM   3241 N N   . ALA B 1 127 ? 4.78551   -3.33250  -9.21601  1.000 9.55131  ? 129 ALA B N   1 
ATOM   3242 C CA  . ALA B 1 127 ? 4.96137   -4.56730  -8.46509  1.000 6.32989  ? 129 ALA B CA  1 
ATOM   3243 C C   . ALA B 1 127 ? 6.13859   -4.42278  -7.50753  1.000 9.51751  ? 129 ALA B C   1 
ATOM   3244 O O   . ALA B 1 127 ? 7.15045   -3.80394  -7.84586  1.000 8.32406  ? 129 ALA B O   1 
ATOM   3245 C CB  . ALA B 1 127 ? 5.19531   -5.76210  -9.39597  1.000 10.59177 ? 129 ALA B CB  1 
ATOM   3246 N N   . MET B 1 128 ? 5.99864   -4.99435  -6.31073  1.000 10.43718 ? 130 MET B N   1 
ATOM   3247 C CA  . MET B 1 128 ? 7.11134   -5.09676  -5.37007  1.000 10.95971 ? 130 MET B CA  1 
ATOM   3248 C C   . MET B 1 128 ? 8.04085   -6.21355  -5.84392  1.000 6.54816  ? 130 MET B C   1 
ATOM   3249 O O   . MET B 1 128 ? 7.65796   -7.38383  -5.85448  1.000 7.69595  ? 130 MET B O   1 
ATOM   3250 C CB  . MET B 1 128 ? 6.58248   -5.34495  -3.95708  1.000 8.25786  ? 130 MET B CB  1 
ATOM   3251 C CG  . MET B 1 128 ? 7.65293   -5.50020  -2.86698  1.000 9.92181  ? 130 MET B CG  1 
ATOM   3252 S SD  . MET B 1 128 ? 8.72430   -4.06100  -2.67048  1.000 12.96400 ? 130 MET B SD  1 
ATOM   3253 C CE  . MET B 1 128 ? 7.65028   -2.86805  -1.89158  1.000 4.22812  ? 130 MET B CE  1 
ATOM   3254 N N   . ARG B 1 129 ? 9.25491   -5.85513  -6.25036  1.000 8.62461  ? 131 ARG B N   1 
ATOM   3255 C CA  . ARG B 1 129 ? 10.18749  -6.82914  -6.79871  1.000 11.78844 ? 131 ARG B CA  1 
ATOM   3256 C C   . ARG B 1 129 ? 10.77771  -7.68754  -5.67787  1.000 11.39786 ? 131 ARG B C   1 
ATOM   3257 O O   . ARG B 1 129 ? 10.60680  -7.41379  -4.48660  1.000 8.80693  ? 131 ARG B O   1 
ATOM   3258 C CB  . ARG B 1 129 ? 11.31593  -6.13244  -7.56205  1.000 8.85706  ? 131 ARG B CB  1 
ATOM   3259 C CG  . ARG B 1 129 ? 10.86886  -5.12566  -8.60896  1.000 13.87567 ? 131 ARG B CG  1 
ATOM   3260 C CD  . ARG B 1 129 ? 10.14306  -5.78458  -9.73925  1.000 13.83079 ? 131 ARG B CD  1 
ATOM   3261 N NE  . ARG B 1 129 ? 10.95464  -6.81957  -10.37604 1.000 12.30630 ? 131 ARG B NE  1 
ATOM   3262 C CZ  . ARG B 1 129 ? 10.52112  -7.58848  -11.37065 1.000 15.73746 ? 131 ARG B CZ  1 
ATOM   3263 N NH1 . ARG B 1 129 ? 9.28568   -7.41072  -11.85142 1.000 9.29268  ? 131 ARG B NH1 1 
ATOM   3264 N NH2 . ARG B 1 129 ? 11.31838  -8.52081  -11.89369 1.000 9.44078  ? 131 ARG B NH2 1 
ATOM   3265 N N   . HIS B 1 130 ? 11.49623  -8.73885  -6.07779  1.000 9.53555  ? 132 HIS B N   1 
ATOM   3266 C CA  . HIS B 1 130 ? 12.08329  -9.64092  -5.09727  1.000 12.75170 ? 132 HIS B CA  1 
ATOM   3267 C C   . HIS B 1 130 ? 13.28281  -9.02724  -4.40441  1.000 9.13941  ? 132 HIS B C   1 
ATOM   3268 O O   . HIS B 1 130 ? 13.56467  -9.39450  -3.26602  1.000 9.76337  ? 132 HIS B O   1 
ATOM   3269 C CB  . HIS B 1 130 ? 12.45117  -10.97819 -5.74422  1.000 11.81453 ? 132 HIS B CB  1 
ATOM   3270 C CG  . HIS B 1 130 ? 11.29958  -11.93175 -5.79413  1.000 20.47793 ? 132 HIS B CG  1 
ATOM   3271 N ND1 . HIS B 1 130 ? 10.96045  -12.74548 -4.73306  1.000 26.50247 ? 132 HIS B ND1 1 
ATOM   3272 C CD2 . HIS B 1 130 ? 10.36421  -12.15170 -6.75032  1.000 21.47584 ? 132 HIS B CD2 1 
ATOM   3273 C CE1 . HIS B 1 130 ? 9.88031   -13.44430 -5.04327  1.000 22.72342 ? 132 HIS B CE1 1 
ATOM   3274 N NE2 . HIS B 1 130 ? 9.49704   -13.10020 -6.26102  1.000 23.01587 ? 132 HIS B NE2 1 
ATOM   3275 N N   . ASN B 1 131 ? 13.95804  -8.07310  -5.03121  1.000 5.36788  ? 133 ASN B N   1 
ATOM   3276 C CA  . ASN B 1 131 ? 14.99888  -7.31961  -4.35329  1.000 11.65638 ? 133 ASN B CA  1 
ATOM   3277 C C   . ASN B 1 131 ? 14.43342  -6.11399  -3.60685  1.000 10.39904 ? 133 ASN B C   1 
ATOM   3278 O O   . ASN B 1 131 ? 15.18719  -5.19005  -3.27081  1.000 9.37618  ? 133 ASN B O   1 
ATOM   3279 C CB  . ASN B 1 131 ? 16.09858  -6.90613  -5.34998  1.000 10.12643 ? 133 ASN B CB  1 
ATOM   3280 C CG  . ASN B 1 131 ? 15.64222  -5.84790  -6.33472  1.000 13.85986 ? 133 ASN B CG  1 
ATOM   3281 O OD1 . ASN B 1 131 ? 14.50418  -5.39365  -6.28615  1.000 9.96977  ? 133 ASN B OD1 1 
ATOM   3282 N ND2 . ASN B 1 131 ? 16.53623  -5.44410  -7.23529  1.000 11.56865 ? 133 ASN B ND2 1 
ATOM   3283 N N   . PHE B 1 132 ? 13.11576  -6.10129  -3.38196  1.000 8.24572  ? 134 PHE B N   1 
ATOM   3284 C CA  . PHE B 1 132 ? 12.37275  -5.07425  -2.64351  1.000 9.47196  ? 134 PHE B CA  1 
ATOM   3285 C C   . PHE B 1 132 ? 12.50914  -3.67507  -3.22680  1.000 9.28256  ? 134 PHE B C   1 
ATOM   3286 O O   . PHE B 1 132 ? 12.37206  -2.68723  -2.49490  1.000 10.45678 ? 134 PHE B O   1 
ATOM   3287 C CB  . PHE B 1 132 ? 12.76487  -5.04852  -1.16020  1.000 6.61417  ? 134 PHE B CB  1 
ATOM   3288 C CG  . PHE B 1 132 ? 12.37570  -6.28702  -0.42544  1.000 5.32517  ? 134 PHE B CG  1 
ATOM   3289 C CD1 . PHE B 1 132 ? 11.04912  -6.54049  -0.12958  1.000 10.43991 ? 134 PHE B CD1 1 
ATOM   3290 C CD2 . PHE B 1 132 ? 13.33058  -7.22519  -0.07604  1.000 10.95487 ? 134 PHE B CD2 1 
ATOM   3291 C CE1 . PHE B 1 132 ? 10.68648  -7.69023  0.54042   1.000 10.04153 ? 134 PHE B CE1 1 
ATOM   3292 C CE2 . PHE B 1 132 ? 12.97745  -8.37571  0.58829   1.000 8.43336  ? 134 PHE B CE2 1 
ATOM   3293 C CZ  . PHE B 1 132 ? 11.64593  -8.60666  0.89164   1.000 8.88254  ? 134 PHE B CZ  1 
ATOM   3294 N N   . THR B 1 133 ? 12.77006  -3.54014  -4.51994  1.000 6.98607  ? 135 THR B N   1 
ATOM   3295 C CA  . THR B 1 133 ? 12.66288  -2.23487  -5.15246  1.000 8.31695  ? 135 THR B CA  1 
ATOM   3296 C C   . THR B 1 133 ? 11.38622  -2.15954  -5.97870  1.000 10.52032 ? 135 THR B C   1 
ATOM   3297 O O   . THR B 1 133 ? 10.69592  -3.15416  -6.19913  1.000 10.39953 ? 135 THR B O   1 
ATOM   3298 C CB  . THR B 1 133 ? 13.88190  -1.92579  -6.03469  1.000 10.26100 ? 135 THR B CB  1 
ATOM   3299 O OG1 . THR B 1 133 ? 13.78763  -2.67518  -7.24908  1.000 11.20239 ? 135 THR B OG1 1 
ATOM   3300 C CG2 . THR B 1 133 ? 15.14787  -2.28762  -5.32279  1.000 6.88880  ? 135 THR B CG2 1 
ATOM   3301 N N   . ILE B 1 134 ? 11.08264  -0.94296  -6.42430  1.000 8.92303  ? 136 ILE B N   1 
ATOM   3302 C CA  . ILE B 1 134 ? 9.94770   -0.63167  -7.28209  1.000 10.71687 ? 136 ILE B CA  1 
ATOM   3303 C C   . ILE B 1 134 ? 10.52512  -0.04394  -8.56179  1.000 11.16322 ? 136 ILE B C   1 
ATOM   3304 O O   . ILE B 1 134 ? 11.36251  0.86206   -8.50391  1.000 16.27349 ? 136 ILE B O   1 
ATOM   3305 C CB  . ILE B 1 134 ? 8.98007   0.36740   -6.60012  1.000 8.88113  ? 136 ILE B CB  1 
ATOM   3306 C CG1 . ILE B 1 134 ? 8.27230   -0.26789  -5.41047  1.000 11.87862 ? 136 ILE B CG1 1 
ATOM   3307 C CG2 . ILE B 1 134 ? 7.94992   0.86761   -7.53227  1.000 13.15468 ? 136 ILE B CG2 1 
ATOM   3308 C CD1 . ILE B 1 134 ? 7.88956   -1.68004  -5.64284  1.000 12.14324 ? 136 ILE B CD1 1 
ATOM   3309 N N   . LYS B 1 135 ? 10.11866  -0.58244  -9.71035  1.000 13.58337 ? 137 LYS B N   1 
ATOM   3310 C CA  . LYS B 1 135 ? 10.47005  0.01143   -10.99704 1.000 11.53910 ? 137 LYS B CA  1 
ATOM   3311 C C   . LYS B 1 135 ? 9.37302   1.01324   -11.33919 1.000 10.47433 ? 137 LYS B C   1 
ATOM   3312 O O   . LYS B 1 135 ? 8.41114   0.72053   -12.04764 1.000 17.31053 ? 137 LYS B O   1 
ATOM   3313 C CB  . LYS B 1 135 ? 10.64125  -1.06398  -12.06553 1.000 13.25080 ? 137 LYS B CB  1 
ATOM   3314 N N   . GLY B 1 136 ? 9.50989   2.22001   -10.78816 1.000 14.01978 ? 138 GLY B N   1 
ATOM   3315 C CA  . GLY B 1 136 ? 8.50404   3.24907   -10.91285 1.000 16.31893 ? 138 GLY B CA  1 
ATOM   3316 C C   . GLY B 1 136 ? 8.94151   4.39529   -11.80922 1.000 13.64371 ? 138 GLY B C   1 
ATOM   3317 O O   . GLY B 1 136 ? 10.02019  4.40022   -12.39623 1.000 16.94804 ? 138 GLY B O   1 
ATOM   3318 N N   . SER B 1 137 ? 8.06316   5.38513   -11.90258 1.000 14.24667 ? 139 SER B N   1 
ATOM   3319 C CA  . SER B 1 137 ? 8.33080   6.61530   -12.64864 1.000 16.00538 ? 139 SER B CA  1 
ATOM   3320 C C   . SER B 1 137 ? 8.14366   7.77279   -11.67193 1.000 23.26180 ? 139 SER B C   1 
ATOM   3321 O O   . SER B 1 137 ? 7.00872   8.18587   -11.38561 1.000 17.11069 ? 139 SER B O   1 
ATOM   3322 C CB  . SER B 1 137 ? 7.41805   6.73548   -13.86897 1.000 25.81913 ? 139 SER B CB  1 
ATOM   3323 O OG  . SER B 1 137 ? 7.78748   7.83341   -14.69627 1.000 23.62552 ? 139 SER B OG  1 
ATOM   3324 N N   . PHE B 1 138 ? 9.26656   8.27520   -11.15523 1.000 11.57304 ? 140 PHE B N   1 
ATOM   3325 C CA  . PHE B 1 138 ? 9.27720   9.21759   -10.04483 1.000 16.56140 ? 140 PHE B CA  1 
ATOM   3326 C C   . PHE B 1 138 ? 10.32605  10.27636  -10.32357 1.000 15.32069 ? 140 PHE B C   1 
ATOM   3327 O O   . PHE B 1 138 ? 11.49923  9.94242   -10.51458 1.000 18.56342 ? 140 PHE B O   1 
ATOM   3328 C CB  . PHE B 1 138 ? 9.60118   8.51334   -8.72062  1.000 12.06119 ? 140 PHE B CB  1 
ATOM   3329 C CG  . PHE B 1 138 ? 8.45366   7.78152   -8.11873  1.000 10.82984 ? 140 PHE B CG  1 
ATOM   3330 C CD1 . PHE B 1 138 ? 7.19714   8.37274   -8.03882  1.000 16.07667 ? 140 PHE B CD1 1 
ATOM   3331 C CD2 . PHE B 1 138 ? 8.62585   6.51028   -7.60297  1.000 11.33711 ? 140 PHE B CD2 1 
ATOM   3332 C CE1 . PHE B 1 138 ? 6.14285   7.70860   -7.46493  1.000 8.73502  ? 140 PHE B CE1 1 
ATOM   3333 C CE2 . PHE B 1 138 ? 7.57180   5.83706   -7.01852  1.000 10.67438 ? 140 PHE B CE2 1 
ATOM   3334 C CZ  . PHE B 1 138 ? 6.32620   6.43862   -6.95502  1.000 10.02866 ? 140 PHE B CZ  1 
ATOM   3335 N N   . LEU B 1 139 ? 9.91974   11.54210  -10.32803 1.000 13.02255 ? 141 LEU B N   1 
ATOM   3336 C CA  . LEU B 1 139 ? 10.86091  12.63644  -10.50259 1.000 17.67558 ? 141 LEU B CA  1 
ATOM   3337 C C   . LEU B 1 139 ? 11.22819  13.20989  -9.13284  1.000 17.17671 ? 141 LEU B C   1 
ATOM   3338 O O   . LEU B 1 139 ? 10.70046  12.78760  -8.09944  1.000 18.41700 ? 141 LEU B O   1 
ATOM   3339 C CB  . LEU B 1 139 ? 10.27086  13.68772  -11.44845 1.000 17.92134 ? 141 LEU B CB  1 
ATOM   3340 C CG  . LEU B 1 139 ? 10.02889  13.17378  -12.87166 1.000 16.43199 ? 141 LEU B CG  1 
ATOM   3341 C CD1 . LEU B 1 139 ? 9.31945   14.19957  -13.73673 1.000 14.57713 ? 141 LEU B CD1 1 
ATOM   3342 C CD2 . LEU B 1 139 ? 11.35430  12.77746  -13.49678 1.000 15.69190 ? 141 LEU B CD2 1 
ATOM   3343 N N   . ASN B 1 140 ? 12.17032  14.15647  -9.11937  1.000 14.11223 ? 142 ASN B N   1 
ATOM   3344 C CA  . ASN B 1 140 ? 12.46179  14.89644  -7.89650  1.000 14.65180 ? 142 ASN B CA  1 
ATOM   3345 C C   . ASN B 1 140 ? 11.17118  15.39964  -7.26531  1.000 16.42447 ? 142 ASN B C   1 
ATOM   3346 O O   . ASN B 1 140 ? 10.25377  15.84752  -7.96068  1.000 18.26721 ? 142 ASN B O   1 
ATOM   3347 C CB  . ASN B 1 140 ? 13.38390  16.08457  -8.17659  1.000 16.48256 ? 142 ASN B CB  1 
ATOM   3348 C CG  . ASN B 1 140 ? 14.82419  15.66694  -8.42229  1.000 26.98341 ? 142 ASN B CG  1 
ATOM   3349 O OD1 . ASN B 1 140 ? 15.15862  14.48535  -8.39425  1.000 24.92518 ? 142 ASN B OD1 1 
ATOM   3350 N ND2 . ASN B 1 140 ? 15.68899  16.64782  -8.65305  1.000 34.21024 ? 142 ASN B ND2 1 
ATOM   3351 N N   . GLY B 1 141 ? 11.10613  15.31958  -5.93795  1.000 17.48479 ? 143 GLY B N   1 
ATOM   3352 C CA  . GLY B 1 141 ? 9.94417   15.79372  -5.21815  1.000 15.78142 ? 143 GLY B CA  1 
ATOM   3353 C C   . GLY B 1 141 ? 8.74562   14.87419  -5.24117  1.000 11.03681 ? 143 GLY B C   1 
ATOM   3354 O O   . GLY B 1 141 ? 7.67933   15.27411  -4.76727  1.000 12.68480 ? 143 GLY B O   1 
ATOM   3355 N N   . SER B 1 142 ? 8.88263   13.65146  -5.76156  1.000 11.19137 ? 144 SER B N   1 
ATOM   3356 C CA  . SER B 1 142 ? 7.77654   12.70127  -5.73685  1.000 12.78823 ? 144 SER B CA  1 
ATOM   3357 C C   . SER B 1 142 ? 7.61508   12.01486  -4.38228  1.000 9.97918  ? 144 SER B C   1 
ATOM   3358 O O   . SER B 1 142 ? 6.56557   11.40584  -4.14873  1.000 5.60237  ? 144 SER B O   1 
ATOM   3359 C CB  . SER B 1 142 ? 7.95737   11.64610  -6.82856  1.000 9.25713  ? 144 SER B CB  1 
ATOM   3360 O OG  . SER B 1 142 ? 9.23684   11.06000  -6.75058  1.000 9.72220  ? 144 SER B OG  1 
ATOM   3361 N N   . CYS B 1 143 ? 8.62470   12.10251  -3.49847  1.000 5.56834  ? 145 CYS B N   1 
ATOM   3362 C CA  . CYS B 1 143 ? 8.54499   11.55052  -2.14664  1.000 6.01348  ? 145 CYS B CA  1 
ATOM   3363 C C   . CYS B 1 143 ? 7.23137   11.92394  -1.46275  1.000 4.22490  ? 145 CYS B C   1 
ATOM   3364 O O   . CYS B 1 143 ? 6.78276   13.06733  -1.53440  1.000 3.92325  ? 145 CYS B O   1 
ATOM   3365 C CB  . CYS B 1 143 ? 9.70847   12.06964  -1.29527  1.000 3.47628  ? 145 CYS B CB  1 
ATOM   3366 S SG  . CYS B 1 143 ? 11.30172  12.19483  -2.14801  1.000 8.45191  ? 145 CYS B SG  1 
ATOM   3367 N N   . GLY B 1 144 ? 6.65313   10.96525  -0.74455  1.000 3.81006  ? 146 GLY B N   1 
ATOM   3368 C CA  . GLY B 1 144 ? 5.33686   11.10648  -0.16237  1.000 6.69539  ? 146 GLY B CA  1 
ATOM   3369 C C   . GLY B 1 144 ? 4.20863   10.50601  -0.98650  1.000 6.34128  ? 146 GLY B C   1 
ATOM   3370 O O   . GLY B 1 144 ? 3.13365   10.24956  -0.42954  1.000 5.59960  ? 146 GLY B O   1 
ATOM   3371 N N   . SER B 1 145 ? 4.41990   10.29172  -2.29194  1.000 4.24926  ? 147 SER B N   1 
ATOM   3372 C CA  . SER B 1 145 ? 3.45779   9.56960   -3.12811  1.000 4.13693  ? 147 SER B CA  1 
ATOM   3373 C C   . SER B 1 145 ? 3.24353   8.16817   -2.56817  1.000 6.49900  ? 147 SER B C   1 
ATOM   3374 O O   . SER B 1 145 ? 4.19008   7.52612   -2.10365  1.000 4.85314  ? 147 SER B O   1 
ATOM   3375 C CB  . SER B 1 145 ? 3.96166   9.45871   -4.57814  1.000 4.54456  ? 147 SER B CB  1 
ATOM   3376 O OG  . SER B 1 145 ? 3.99145   10.70902  -5.25855  1.000 6.54396  ? 147 SER B OG  1 
ATOM   3377 N N   . VAL B 1 146 ? 2.00908   7.66408   -2.65202  1.000 2.76128  ? 148 VAL B N   1 
ATOM   3378 C CA  . VAL B 1 146 ? 1.70395   6.37385   -2.04915  1.000 2.97468  ? 148 VAL B CA  1 
ATOM   3379 C C   . VAL B 1 146 ? 1.32285   5.33487   -3.09690  1.000 3.58893  ? 148 VAL B C   1 
ATOM   3380 O O   . VAL B 1 146 ? 0.96542   5.64659   -4.23625  1.000 3.83209  ? 148 VAL B O   1 
ATOM   3381 C CB  . VAL B 1 146 ? 0.60290   6.48484   -0.97267  1.000 4.49314  ? 148 VAL B CB  1 
ATOM   3382 C CG1 . VAL B 1 146 ? 1.10151   7.39427   0.15326   1.000 4.55213  ? 148 VAL B CG1 1 
ATOM   3383 C CG2 . VAL B 1 146 ? -0.72639  6.99345   -1.56988  1.000 2.11490  ? 148 VAL B CG2 1 
ATOM   3384 N N   . GLY B 1 147 ? 1.42600   4.07126   -2.68321  1.000 3.46211  ? 149 GLY B N   1 
ATOM   3385 C CA  . GLY B 1 147 ? 0.88292   2.94632   -3.41845  1.000 4.07065  ? 149 GLY B CA  1 
ATOM   3386 C C   . GLY B 1 147 ? -0.27008  2.32334   -2.65247  1.000 5.79405  ? 149 GLY B C   1 
ATOM   3387 O O   . GLY B 1 147 ? -0.33067  2.40695   -1.41774  1.000 4.57487  ? 149 GLY B O   1 
ATOM   3388 N N   . PHE B 1 148 ? -1.17886  1.67291   -3.38189  1.000 3.84299  ? 150 PHE B N   1 
ATOM   3389 C CA  . PHE B 1 148 ? -2.40346  1.19983   -2.74641  1.000 5.41928  ? 150 PHE B CA  1 
ATOM   3390 C C   . PHE B 1 148 ? -3.07209  0.11766   -3.58825  1.000 6.32407  ? 150 PHE B C   1 
ATOM   3391 O O   . PHE B 1 148 ? -2.77828  -0.04732  -4.77539  1.000 5.05939  ? 150 PHE B O   1 
ATOM   3392 C CB  . PHE B 1 148 ? -3.38767  2.35689   -2.50518  1.000 3.74498  ? 150 PHE B CB  1 
ATOM   3393 C CG  . PHE B 1 148 ? -3.82354  3.04936   -3.76196  1.000 4.11122  ? 150 PHE B CG  1 
ATOM   3394 C CD1 . PHE B 1 148 ? -3.03358  4.02341   -4.34866  1.000 3.33009  ? 150 PHE B CD1 1 
ATOM   3395 C CD2 . PHE B 1 148 ? -5.02730  2.72977   -4.36016  1.000 3.67938  ? 150 PHE B CD2 1 
ATOM   3396 C CE1 . PHE B 1 148 ? -3.42275  4.64301   -5.52902  1.000 3.92939  ? 150 PHE B CE1 1 
ATOM   3397 C CE2 . PHE B 1 148 ? -5.42513  3.35631   -5.53071  1.000 3.43965  ? 150 PHE B CE2 1 
ATOM   3398 C CZ  . PHE B 1 148 ? -4.62820  4.30387   -6.11496  1.000 5.34460  ? 150 PHE B CZ  1 
ATOM   3399 N N   . ASN B 1 149 ? -3.98675  -0.61395  -2.94168  1.000 5.55019  ? 151 ASN B N   1 
ATOM   3400 C CA  . ASN B 1 149 ? -4.95401  -1.49315  -3.59368  1.000 5.24020  ? 151 ASN B CA  1 
ATOM   3401 C C   . ASN B 1 149 ? -6.34609  -1.09732  -3.10724  1.000 7.17830  ? 151 ASN B C   1 
ATOM   3402 O O   . ASN B 1 149 ? -6.49956  -0.53577  -2.02102  1.000 7.75383  ? 151 ASN B O   1 
ATOM   3403 C CB  . ASN B 1 149 ? -4.67896  -2.98000  -3.27519  1.000 6.62472  ? 151 ASN B CB  1 
ATOM   3404 C CG  . ASN B 1 149 ? -3.52614  -3.55759  -4.07475  1.000 11.41708 ? 151 ASN B CG  1 
ATOM   3405 O OD1 . ASN B 1 149 ? -3.70711  -3.99757  -5.21321  1.000 10.13894 ? 151 ASN B OD1 1 
ATOM   3406 N ND2 . ASN B 1 149 ? -2.32257  -3.55984  -3.47920  1.000 5.00412  ? 151 ASN B ND2 1 
ATOM   3407 N N   . ILE B 1 150 ? -7.37487  -1.36447  -3.89978  1.000 11.26622 ? 152 ILE B N   1 
ATOM   3408 C CA  . ILE B 1 150 ? -8.74217  -1.12645  -3.43801  1.000 11.27480 ? 152 ILE B CA  1 
ATOM   3409 C C   . ILE B 1 150 ? -9.51300  -2.43839  -3.42727  1.000 19.08173 ? 152 ILE B C   1 
ATOM   3410 O O   . ILE B 1 150 ? -9.43575  -3.23104  -4.37467  1.000 16.45950 ? 152 ILE B O   1 
ATOM   3411 C CB  . ILE B 1 150 ? -9.50783  -0.08207  -4.27578  1.000 15.17008 ? 152 ILE B CB  1 
ATOM   3412 C CG1 . ILE B 1 150 ? -8.80877  1.27094   -4.26377  1.000 7.85796  ? 152 ILE B CG1 1 
ATOM   3413 C CG2 . ILE B 1 150 ? -10.91859 0.09933   -3.70676  1.000 11.27724 ? 152 ILE B CG2 1 
ATOM   3414 C CD1 . ILE B 1 150 ? -9.42401  2.24460   -5.26370  1.000 11.36457 ? 152 ILE B CD1 1 
ATOM   3415 N N   . ASP B 1 151 ? -10.29341 -2.64360  -2.36069  1.000 21.32603 ? 153 ASP B N   1 
ATOM   3416 C CA  . ASP B 1 151 ? -11.08255 -3.86215  -2.16141  1.000 19.75029 ? 153 ASP B CA  1 
ATOM   3417 C C   . ASP B 1 151 ? -12.47183 -3.44633  -1.66636  1.000 23.83994 ? 153 ASP B C   1 
ATOM   3418 O O   . ASP B 1 151 ? -12.68130 -3.27021  -0.46338  1.000 30.31971 ? 153 ASP B O   1 
ATOM   3419 C CB  . ASP B 1 151 ? -10.36451 -4.79230  -1.18859  1.000 23.12874 ? 153 ASP B CB  1 
ATOM   3420 C CG  . ASP B 1 151 ? -8.86775  -4.96125  -1.53111  1.000 40.94845 ? 153 ASP B CG  1 
ATOM   3421 O OD1 . ASP B 1 151 ? -8.55435  -5.22328  -2.71737  1.000 48.81871 ? 153 ASP B OD1 1 
ATOM   3422 O OD2 . ASP B 1 151 ? -7.99706  -4.81937  -0.63164  1.000 34.16030 ? 153 ASP B OD2 1 
ATOM   3423 N N   . TYR B 1 152 ? -13.40855 -3.27560  -2.60720  1.000 24.13834 ? 154 TYR B N   1 
ATOM   3424 C CA  . TYR B 1 152 ? -14.77937 -2.84094  -2.33131  1.000 30.53800 ? 154 TYR B CA  1 
ATOM   3425 C C   . TYR B 1 152 ? -14.83670 -1.69419  -1.32443  1.000 31.49137 ? 154 TYR B C   1 
ATOM   3426 O O   . TYR B 1 152 ? -15.16223 -1.91624  -0.15251  1.000 34.19992 ? 154 TYR B O   1 
ATOM   3427 C CB  . TYR B 1 152 ? -15.63137 -4.01719  -1.82937  1.000 25.13223 ? 154 TYR B CB  1 
ATOM   3428 N N   . ASP B 1 153 ? -14.50517 -0.48066  -1.77649  1.000 31.38751 ? 155 ASP B N   1 
ATOM   3429 C CA  . ASP B 1 153 ? -14.48436 0.80354   -1.05970  1.000 28.75545 ? 155 ASP B CA  1 
ATOM   3430 C C   . ASP B 1 153 ? -13.43987 0.91678   0.05890   1.000 21.21970 ? 155 ASP B C   1 
ATOM   3431 O O   . ASP B 1 153 ? -13.39429 1.96186   0.72036   1.000 24.16660 ? 155 ASP B O   1 
ATOM   3432 C CB  . ASP B 1 153 ? -15.86733 1.21012   -0.49722  1.000 24.96153 ? 155 ASP B CB  1 
ATOM   3433 C CG  . ASP B 1 153 ? -16.30731 0.40368   0.74239   1.000 35.12487 ? 155 ASP B CG  1 
ATOM   3434 O OD1 . ASP B 1 153 ? -15.61745 0.39503   1.78174   1.000 35.63452 ? 155 ASP B OD1 1 
ATOM   3435 O OD2 . ASP B 1 153 ? -17.38633 -0.22033  0.67929   1.000 52.13734 ? 155 ASP B OD2 1 
ATOM   3436 N N   . CYS B 1 154 ? -12.59637 -0.08647  0.29298   1.000 21.76662 ? 156 CYS B N   1 
ATOM   3437 C CA  . CYS B 1 154 ? -11.53965 0.02128   1.29802   1.000 19.66681 ? 156 CYS B CA  1 
ATOM   3438 C C   . CYS B 1 154 ? -10.18132 0.13891   0.61100   1.000 13.45878 ? 156 CYS B C   1 
ATOM   3439 O O   . CYS B 1 154 ? -9.76788  -0.76462  -0.12545  1.000 10.97224 ? 156 CYS B O   1 
ATOM   3440 C CB  . CYS B 1 154 ? -11.55758 -1.16845  2.26099   1.000 16.34170 ? 156 CYS B CB  1 
ATOM   3441 S SG  . CYS B 1 154 ? -10.23324 -1.12773  3.52282   1.000 15.90997 ? 156 CYS B SG  1 
ATOM   3442 N N   . VAL B 1 155 ? -9.48480  1.24194   0.87072   1.000 12.88689 ? 157 VAL B N   1 
ATOM   3443 C CA  . VAL B 1 155 ? -8.16260  1.48388   0.30539   1.000 12.71368 ? 157 VAL B CA  1 
ATOM   3444 C C   . VAL B 1 155 ? -7.10554  0.89339   1.23301   1.000 10.16061 ? 157 VAL B C   1 
ATOM   3445 O O   . VAL B 1 155 ? -6.97179  1.31349   2.38566   1.000 9.13070  ? 157 VAL B O   1 
ATOM   3446 C CB  . VAL B 1 155 ? -7.91783  2.98195   0.09339   1.000 11.07477 ? 157 VAL B CB  1 
ATOM   3447 C CG1 . VAL B 1 155 ? -6.51357  3.20487   -0.50737  1.000 9.56599  ? 157 VAL B CG1 1 
ATOM   3448 C CG2 . VAL B 1 155 ? -8.99271  3.55579   -0.78128  1.000 8.90955  ? 157 VAL B CG2 1 
ATOM   3449 N N   . SER B 1 156 ? -6.34536  -0.07296  0.73587   1.000 11.65208 ? 158 SER B N   1 
ATOM   3450 C CA  . SER B 1 156 ? -5.23342  -0.64460  1.49352   1.000 7.47760  ? 158 SER B CA  1 
ATOM   3451 C C   . SER B 1 156 ? -3.95417  0.03223   1.02021   1.000 5.69229  ? 158 SER B C   1 
ATOM   3452 O O   . SER B 1 156 ? -3.44339  -0.28066  -0.05666  1.000 4.56938  ? 158 SER B O   1 
ATOM   3453 C CB  . SER B 1 156 ? -5.16618  -2.15652  1.31878   1.000 5.56680  ? 158 SER B CB  1 
ATOM   3454 O OG  . SER B 1 156 ? -6.26452  -2.77566  1.96579   1.000 14.03362 ? 158 SER B OG  1 
ATOM   3455 N N   . PHE B 1 157 ? -3.44539  0.96641   1.83456   1.000 7.79591  ? 159 PHE B N   1 
ATOM   3456 C CA  . PHE B 1 157 ? -2.17725  1.63890   1.56862   1.000 4.90798  ? 159 PHE B CA  1 
ATOM   3457 C C   . PHE B 1 157 ? -1.02533  0.70010   1.91086   1.000 4.65956  ? 159 PHE B C   1 
ATOM   3458 O O   . PHE B 1 157 ? -0.94716  0.19809   3.03901   1.000 5.70360  ? 159 PHE B O   1 
ATOM   3459 C CB  . PHE B 1 157 ? -2.07203  2.92797   2.38366   1.000 4.16893  ? 159 PHE B CB  1 
ATOM   3460 C CG  . PHE B 1 157 ? -3.07486  3.99547   2.00281   1.000 4.51549  ? 159 PHE B CG  1 
ATOM   3461 C CD1 . PHE B 1 157 ? -2.89635  4.76042   0.85946   1.000 3.33644  ? 159 PHE B CD1 1 
ATOM   3462 C CD2 . PHE B 1 157 ? -4.17865  4.25341   2.80888   1.000 8.32436  ? 159 PHE B CD2 1 
ATOM   3463 C CE1 . PHE B 1 157 ? -3.79411  5.75722   0.52292   1.000 2.76659  ? 159 PHE B CE1 1 
ATOM   3464 C CE2 . PHE B 1 157 ? -5.09291  5.24656   2.47932   1.000 4.52284  ? 159 PHE B CE2 1 
ATOM   3465 C CZ  . PHE B 1 157 ? -4.90198  5.99751   1.33519   1.000 5.15780  ? 159 PHE B CZ  1 
ATOM   3466 N N   . CYS B 1 158 ? -0.12084  0.47457   0.94946   1.000 3.10326  ? 160 CYS B N   1 
ATOM   3467 C CA  . CYS B 1 158 ? 0.99491   -0.44643  1.14026   1.000 5.58131  ? 160 CYS B CA  1 
ATOM   3468 C C   . CYS B 1 158 ? 2.37723   0.15790   0.91432   1.000 4.05974  ? 160 CYS B C   1 
ATOM   3469 O O   . CYS B 1 158 ? 3.37534   -0.49643  1.25290   1.000 8.37579  ? 160 CYS B O   1 
ATOM   3470 C CB  . CYS B 1 158 ? 0.84408   -1.67662  0.22287   1.000 5.72244  ? 160 CYS B CB  1 
ATOM   3471 S SG  . CYS B 1 158 ? 0.76531   -1.31600  -1.55082  1.000 5.45271  ? 160 CYS B SG  1 
ATOM   3472 N N   . TYR B 1 159 ? 2.48082   1.37546   0.38251   1.000 3.14395  ? 161 TYR B N   1 
ATOM   3473 C CA  . TYR B 1 159 ? 3.77921   1.91237   -0.01518  1.000 5.76711  ? 161 TYR B CA  1 
ATOM   3474 C C   . TYR B 1 159 ? 3.78265   3.43108   0.10816   1.000 5.23257  ? 161 TYR B C   1 
ATOM   3475 O O   . TYR B 1 159 ? 2.83980   4.09447   -0.32252  1.000 3.57142  ? 161 TYR B O   1 
ATOM   3476 C CB  . TYR B 1 159 ? 4.12519   1.50649   -1.46761  1.000 1.87829  ? 161 TYR B CB  1 
ATOM   3477 C CG  . TYR B 1 159 ? 5.47225   2.01535   -1.97362  1.000 3.76624  ? 161 TYR B CG  1 
ATOM   3478 C CD1 . TYR B 1 159 ? 6.66630   1.38119   -1.60223  1.000 4.09391  ? 161 TYR B CD1 1 
ATOM   3479 C CD2 . TYR B 1 159 ? 5.55809   3.11899   -2.81789  1.000 3.62920  ? 161 TYR B CD2 1 
ATOM   3480 C CE1 . TYR B 1 159 ? 7.90390   1.83012   -2.06852  1.000 3.64691  ? 161 TYR B CE1 1 
ATOM   3481 C CE2 . TYR B 1 159 ? 6.80060   3.58551   -3.28422  1.000 2.99711  ? 161 TYR B CE2 1 
ATOM   3482 C CZ  . TYR B 1 159 ? 7.96299   2.92546   -2.90626  1.000 4.74816  ? 161 TYR B CZ  1 
ATOM   3483 O OH  . TYR B 1 159 ? 9.18655   3.36188   -3.35928  1.000 7.34558  ? 161 TYR B OH  1 
ATOM   3484 N N   . MET B 1 160 ? 4.84795   3.98289   0.67606   1.000 2.51115  ? 162 MET B N   1 
ATOM   3485 C CA  . MET B 1 160 ? 5.10358   5.41489   0.56543   1.000 3.13807  ? 162 MET B CA  1 
ATOM   3486 C C   . MET B 1 160 ? 6.49114   5.59405   -0.02398  1.000 4.05889  ? 162 MET B C   1 
ATOM   3487 O O   . MET B 1 160 ? 7.43333   4.92115   0.40165   1.000 2.42142  ? 162 MET B O   1 
ATOM   3488 C CB  . MET B 1 160 ? 4.99995   6.13661   1.91551   1.000 4.21435  ? 162 MET B CB  1 
ATOM   3489 C CG  . MET B 1 160 ? 5.53216   7.56956   1.86876   1.000 3.52714  ? 162 MET B CG  1 
ATOM   3490 S SD  . MET B 1 160 ? 5.23753   8.55114   3.35582   1.000 11.70569 ? 162 MET B SD  1 
ATOM   3491 C CE  . MET B 1 160 ? 3.50253   9.01806   3.08468   1.000 6.74081  ? 162 MET B CE  1 
ATOM   3492 N N   . HIS B 1 161 ? 6.61699   6.49077   -1.00171  1.000 4.08155  ? 163 HIS B N   1 
ATOM   3493 C CA  . HIS B 1 161 ? 7.86805   6.62042   -1.73818  1.000 4.31942  ? 163 HIS B CA  1 
ATOM   3494 C C   . HIS B 1 161 ? 8.87969   7.51714   -1.00541  1.000 4.45846  ? 163 HIS B C   1 
ATOM   3495 O O   . HIS B 1 161 ? 8.54214   8.62082   -0.55745  1.000 4.01676  ? 163 HIS B O   1 
ATOM   3496 C CB  . HIS B 1 161 ? 7.60576   7.16562   -3.14072  1.000 2.63924  ? 163 HIS B CB  1 
ATOM   3497 C CG  . HIS B 1 161 ? 8.86163   7.38015   -3.91811  1.000 3.25728  ? 163 HIS B CG  1 
ATOM   3498 N ND1 . HIS B 1 161 ? 9.78469   6.37542   -4.11282  1.000 6.87845  ? 163 HIS B ND1 1 
ATOM   3499 C CD2 . HIS B 1 161 ? 9.37892   8.48672   -4.50126  1.000 5.65578  ? 163 HIS B CD2 1 
ATOM   3500 C CE1 . HIS B 1 161 ? 10.80960  6.84787   -4.80415  1.000 6.93624  ? 163 HIS B CE1 1 
ATOM   3501 N NE2 . HIS B 1 161 ? 10.58425  8.12503   -5.05851  1.000 6.75770  ? 163 HIS B NE2 1 
ATOM   3502 N N   . HIS B 1 162 ? 10.13415  7.05913   -0.93193  1.000 4.77964  ? 164 HIS B N   1 
ATOM   3503 C CA  . HIS B 1 162 ? 11.20341  7.78130   -0.24270  1.000 4.67575  ? 164 HIS B CA  1 
ATOM   3504 C C   . HIS B 1 162 ? 12.32475  8.23293   -1.16572  1.000 7.11220  ? 164 HIS B C   1 
ATOM   3505 O O   . HIS B 1 162 ? 12.70194  9.40765   -1.13321  1.000 11.49354 ? 164 HIS B O   1 
ATOM   3506 C CB  . HIS B 1 162 ? 11.78870  6.92270   0.88878   1.000 1.00462  ? 164 HIS B CB  1 
ATOM   3507 C CG  . HIS B 1 162 ? 10.90296  6.84155   2.09357   1.000 4.08425  ? 164 HIS B CG  1 
ATOM   3508 N ND1 . HIS B 1 162 ? 11.24948  7.37466   3.31589   1.000 6.34848  ? 164 HIS B ND1 1 
ATOM   3509 C CD2 . HIS B 1 162 ? 9.66292   6.31809   2.25025   1.000 2.85782  ? 164 HIS B CD2 1 
ATOM   3510 C CE1 . HIS B 1 162 ? 10.26796  7.16750   4.17885   1.000 6.24437  ? 164 HIS B CE1 1 
ATOM   3511 N NE2 . HIS B 1 162 ? 9.30172   6.51382   3.56025   1.000 6.33186  ? 164 HIS B NE2 1 
ATOM   3512 N N   . MET B 1 163 ? 12.88475  7.34622   -1.98636  1.000 6.79226  ? 165 MET B N   1 
ATOM   3513 C CA  . MET B 1 163 ? 14.12932  7.70209   -2.65476  1.000 9.57504  ? 165 MET B CA  1 
ATOM   3514 C C   . MET B 1 163 ? 14.35368  6.84190   -3.89176  1.000 7.56453  ? 165 MET B C   1 
ATOM   3515 O O   . MET B 1 163 ? 13.71973  5.80129   -4.07959  1.000 6.80279  ? 165 MET B O   1 
ATOM   3516 C CB  . MET B 1 163 ? 15.31457  7.56592   -1.69552  1.000 10.01195 ? 165 MET B CB  1 
ATOM   3517 C CG  . MET B 1 163 ? 15.50752  6.17961   -1.14631  1.000 8.48336  ? 165 MET B CG  1 
ATOM   3518 S SD  . MET B 1 163 ? 16.42803  6.22896   0.41331   1.000 15.51815 ? 165 MET B SD  1 
ATOM   3519 C CE  . MET B 1 163 ? 17.78124  7.30996   -0.04529  1.000 11.70724 ? 165 MET B CE  1 
ATOM   3520 N N   . GLU B 1 164 ? 15.28658  7.29403   -4.73113  1.000 11.63911 ? 166 GLU B N   1 
ATOM   3521 C CA  . GLU B 1 164 ? 15.69828  6.58712   -5.93810  1.000 11.06950 ? 166 GLU B CA  1 
ATOM   3522 C C   . GLU B 1 164 ? 17.06913  5.96838   -5.72076  1.000 10.68626 ? 166 GLU B C   1 
ATOM   3523 O O   . GLU B 1 164 ? 17.93077  6.56965   -5.07464  1.000 8.36525  ? 166 GLU B O   1 
ATOM   3524 C CB  . GLU B 1 164 ? 15.74301  7.52955   -7.15320  1.000 12.79985 ? 166 GLU B CB  1 
ATOM   3525 N N   . LEU B 1 165 ? 17.26761  4.76864   -6.25973  1.000 10.73872 ? 167 LEU B N   1 
ATOM   3526 C CA  . LEU B 1 165 ? 18.56808  4.12150   -6.24030  1.000 12.29283 ? 167 LEU B CA  1 
ATOM   3527 C C   . LEU B 1 165 ? 19.30383  4.39138   -7.55355  1.000 15.44044 ? 167 LEU B C   1 
ATOM   3528 O O   . LEU B 1 165 ? 18.68429  4.77843   -8.55030  1.000 15.18599 ? 167 LEU B O   1 
ATOM   3529 C CB  . LEU B 1 165 ? 18.40278  2.61282   -5.99597  1.000 13.83784 ? 167 LEU B CB  1 
ATOM   3530 C CG  . LEU B 1 165 ? 17.76821  2.27656   -4.63432  1.000 13.82410 ? 167 LEU B CG  1 
ATOM   3531 C CD1 . LEU B 1 165 ? 17.34903  0.81867   -4.51821  1.000 16.23815 ? 167 LEU B CD1 1 
ATOM   3532 C CD2 . LEU B 1 165 ? 18.69614  2.65439   -3.48978  1.000 10.80654 ? 167 LEU B CD2 1 
ATOM   3533 N N   . PRO B 1 166 ? 20.63889  4.24021   -7.58026  1.000 14.49143 ? 168 PRO B N   1 
ATOM   3534 C CA  . PRO B 1 166 ? 21.40502  4.68109   -8.76095  1.000 12.40801 ? 168 PRO B CA  1 
ATOM   3535 C C   . PRO B 1 166 ? 21.05298  3.96850   -10.05629 1.000 13.08148 ? 168 PRO B C   1 
ATOM   3536 O O   . PRO B 1 166 ? 21.31804  4.52756   -11.12209 1.000 19.83687 ? 168 PRO B O   1 
ATOM   3537 C CB  . PRO B 1 166 ? 22.86357  4.41551   -8.35504  1.000 14.69553 ? 168 PRO B CB  1 
ATOM   3538 C CG  . PRO B 1 166 ? 22.78018  3.44790   -7.21953  1.000 14.73642 ? 168 PRO B CG  1 
ATOM   3539 C CD  . PRO B 1 166 ? 21.53089  3.78583   -6.49588  1.000 11.85410 ? 168 PRO B CD  1 
ATOM   3540 N N   . THR B 1 167 ? 20.47482  2.76744   -10.02167 1.000 11.48543 ? 169 THR B N   1 
ATOM   3541 C CA  . THR B 1 167 ? 19.98558  2.17150   -11.25797 1.000 15.89801 ? 169 THR B CA  1 
ATOM   3542 C C   . THR B 1 167 ? 18.68152  2.79829   -11.74593 1.000 17.51518 ? 169 THR B C   1 
ATOM   3543 O O   . THR B 1 167 ? 18.13746  2.34879   -12.75571 1.000 18.07328 ? 169 THR B O   1 
ATOM   3544 C CB  . THR B 1 167 ? 19.78819  0.66051   -11.08664 1.000 19.68339 ? 169 THR B CB  1 
ATOM   3545 O OG1 . THR B 1 167 ? 19.09363  0.40099   -9.85839  1.000 16.14508 ? 169 THR B OG1 1 
ATOM   3546 C CG2 . THR B 1 167 ? 21.13854  -0.05884  -11.06847 1.000 14.69616 ? 169 THR B CG2 1 
ATOM   3547 N N   . GLY B 1 168 ? 18.14897  3.80523   -11.05889 1.000 18.41187 ? 170 GLY B N   1 
ATOM   3548 C CA  . GLY B 1 168 ? 16.88301  4.38296   -11.45549 1.000 17.01187 ? 170 GLY B CA  1 
ATOM   3549 C C   . GLY B 1 168 ? 15.64948  3.70768   -10.89125 1.000 12.65790 ? 170 GLY B C   1 
ATOM   3550 O O   . GLY B 1 168 ? 14.53398  4.10699   -11.24105 1.000 17.62228 ? 170 GLY B O   1 
ATOM   3551 N N   . VAL B 1 169 ? 15.80722  2.69007   -10.04966 1.000 14.68091 ? 171 VAL B N   1 
ATOM   3552 C CA  . VAL B 1 169 ? 14.67362  2.05582   -9.38512  1.000 10.66243 ? 171 VAL B CA  1 
ATOM   3553 C C   . VAL B 1 169 ? 14.45023  2.77325   -8.05952  1.000 11.74741 ? 171 VAL B C   1 
ATOM   3554 O O   . VAL B 1 169 ? 15.20173  3.68997   -7.71229  1.000 10.82062 ? 171 VAL B O   1 
ATOM   3555 C CB  . VAL B 1 169 ? 14.89809  0.54388   -9.20071  1.000 14.37936 ? 171 VAL B CB  1 
ATOM   3556 C CG1 . VAL B 1 169 ? 15.09708  -0.12488  -10.56086 1.000 13.53030 ? 171 VAL B CG1 1 
ATOM   3557 C CG2 . VAL B 1 169 ? 16.09941  0.26505   -8.28655  1.000 10.07753 ? 171 VAL B CG2 1 
ATOM   3558 N N   . HIS B 1 170 ? 13.42086  2.37385   -7.31022  1.000 12.37343 ? 172 HIS B N   1 
ATOM   3559 C CA  . HIS B 1 170 ? 12.94118  3.18277   -6.20174  1.000 8.71713  ? 172 HIS B CA  1 
ATOM   3560 C C   . HIS B 1 170 ? 12.72554  2.35661   -4.93665  1.000 7.57143  ? 172 HIS B C   1 
ATOM   3561 O O   . HIS B 1 170 ? 12.42964  1.16194   -4.98523  1.000 8.66077  ? 172 HIS B O   1 
ATOM   3562 C CB  . HIS B 1 170 ? 11.66529  3.89706   -6.61264  1.000 8.79569  ? 172 HIS B CB  1 
ATOM   3563 C CG  . HIS B 1 170 ? 11.80935  4.67128   -7.88567  1.000 12.34025 ? 172 HIS B CG  1 
ATOM   3564 N ND1 . HIS B 1 170 ? 11.35507  4.20384   -9.10120  1.000 12.54918 ? 172 HIS B ND1 1 
ATOM   3565 C CD2 . HIS B 1 170 ? 12.39203  5.86779   -8.13754  1.000 14.36849 ? 172 HIS B CD2 1 
ATOM   3566 C CE1 . HIS B 1 170 ? 11.62895  5.08920   -10.04206 1.000 11.67333 ? 172 HIS B CE1 1 
ATOM   3567 N NE2 . HIS B 1 170 ? 12.24731  6.11351   -9.48197  1.000 17.82735 ? 172 HIS B NE2 1 
ATOM   3568 N N   . ALA B 1 171 ? 12.88411  3.02244   -3.79828  1.000 3.81271  ? 173 ALA B N   1 
ATOM   3569 C CA  . ALA B 1 171 ? 12.78271  2.41036   -2.48803  1.000 5.83138  ? 173 ALA B CA  1 
ATOM   3570 C C   . ALA B 1 171 ? 11.85524  3.24004   -1.61041  1.000 2.23414  ? 173 ALA B C   1 
ATOM   3571 O O   . ALA B 1 171 ? 11.89024  4.47184   -1.65972  1.000 3.24596  ? 173 ALA B O   1 
ATOM   3572 C CB  . ALA B 1 171 ? 14.16725  2.29923   -1.82576  1.000 2.30588  ? 173 ALA B CB  1 
ATOM   3573 N N   . GLY B 1 172 ? 11.06379  2.56024   -0.78404  1.000 1.52026  ? 174 GLY B N   1 
ATOM   3574 C CA  . GLY B 1 172 ? 10.15422  3.21464   0.13154   1.000 0.48174  ? 174 GLY B CA  1 
ATOM   3575 C C   . GLY B 1 172 ? 9.83145   2.33589   1.32522   1.000 1.78226  ? 174 GLY B C   1 
ATOM   3576 O O   . GLY B 1 172 ? 10.48229  1.31761   1.56945   1.000 2.59428  ? 174 GLY B O   1 
ATOM   3577 N N   . THR B 1 173 ? 8.81723   2.75160   2.07776   1.000 2.17214  ? 175 THR B N   1 
ATOM   3578 C CA  . THR B 1 173 ? 8.37174   2.07905   3.29174   1.000 3.83607  ? 175 THR B CA  1 
ATOM   3579 C C   . THR B 1 173 ? 6.89857   1.70329   3.16691   1.000 4.67366  ? 175 THR B C   1 
ATOM   3580 O O   . THR B 1 173 ? 6.20704   2.15725   2.25749   1.000 3.64720  ? 175 THR B O   1 
ATOM   3581 C CB  . THR B 1 173 ? 8.54558   2.98386   4.51587   1.000 6.02377  ? 175 THR B CB  1 
ATOM   3582 O OG1 . THR B 1 173 ? 7.65990   4.10923   4.38596   1.000 7.37291  ? 175 THR B OG1 1 
ATOM   3583 C CG2 . THR B 1 173 ? 9.97317   3.46878   4.64478   1.000 3.26149  ? 175 THR B CG2 1 
ATOM   3584 N N   . ASP B 1 174 ? 6.42193   0.85616   4.08623   1.000 4.00392  ? 176 ASP B N   1 
ATOM   3585 C CA  . ASP B 1 174 ? 4.98998   0.77919   4.34245   1.000 6.05236  ? 176 ASP B CA  1 
ATOM   3586 C C   . ASP B 1 174 ? 4.56784   2.02374   5.11168   1.000 4.90011  ? 176 ASP B C   1 
ATOM   3587 O O   . ASP B 1 174 ? 5.38941   2.89374   5.43612   1.000 6.13062  ? 176 ASP B O   1 
ATOM   3588 C CB  . ASP B 1 174 ? 4.62054   -0.50011  5.10312   1.000 6.41124  ? 176 ASP B CB  1 
ATOM   3589 C CG  . ASP B 1 174 ? 5.30411   -0.60347  6.48461   1.000 8.27729  ? 176 ASP B CG  1 
ATOM   3590 O OD1 . ASP B 1 174 ? 5.59235   0.43312   7.12352   1.000 6.53579  ? 176 ASP B OD1 1 
ATOM   3591 O OD2 . ASP B 1 174 ? 5.55664   -1.73841  6.93146   1.000 9.70926  ? 176 ASP B OD2 1 
ATOM   3592 N N   . LEU B 1 175 ? 3.27786   2.10916   5.43446   1.000 2.56885  ? 177 LEU B N   1 
ATOM   3593 C CA  . LEU B 1 175 ? 2.80222   3.32898   6.07007   1.000 4.29006  ? 177 LEU B CA  1 
ATOM   3594 C C   . LEU B 1 175 ? 3.15119   3.37901   7.56107   1.000 8.54746  ? 177 LEU B C   1 
ATOM   3595 O O   . LEU B 1 175 ? 2.94787   4.42061   8.19281   1.000 7.28160  ? 177 LEU B O   1 
ATOM   3596 C CB  . LEU B 1 175 ? 1.28595   3.49742   5.83380   1.000 5.60171  ? 177 LEU B CB  1 
ATOM   3597 C CG  . LEU B 1 175 ? 0.90698   4.30757   4.57607   1.000 5.41694  ? 177 LEU B CG  1 
ATOM   3598 C CD1 . LEU B 1 175 ? 1.05177   5.80223   4.79298   1.000 4.60827  ? 177 LEU B CD1 1 
ATOM   3599 C CD2 . LEU B 1 175 ? 1.72754   3.87156   3.32377   1.000 4.37091  ? 177 LEU B CD2 1 
ATOM   3600 N N   . GLU B 1 176 ? 3.71436   2.30519   8.12263   1.000 5.69755  ? 178 GLU B N   1 
ATOM   3601 C CA  . GLU B 1 176 ? 4.23974   2.31265   9.48423   1.000 6.83451  ? 178 GLU B CA  1 
ATOM   3602 C C   . GLU B 1 176 ? 5.72268   2.69053   9.54967   1.000 6.83445  ? 178 GLU B C   1 
ATOM   3603 O O   . GLU B 1 176 ? 6.32391   2.59233   10.62407  1.000 5.06357  ? 178 GLU B O   1 
ATOM   3604 C CB  . GLU B 1 176 ? 4.01806   0.94927   10.15299  1.000 5.40269  ? 178 GLU B CB  1 
ATOM   3605 C CG  . GLU B 1 176 ? 2.53858   0.65384   10.47657  1.000 11.70282 ? 178 GLU B CG  1 
ATOM   3606 C CD  . GLU B 1 176 ? 2.33242   -0.64472  11.26056  1.000 19.36858 ? 178 GLU B CD  1 
ATOM   3607 O OE1 . GLU B 1 176 ? 2.74536   -0.72175  12.43874  1.000 23.43929 ? 178 GLU B OE1 1 
ATOM   3608 O OE2 . GLU B 1 176 ? 1.75005   -1.59422  10.69561  1.000 27.70581 ? 178 GLU B OE2 1 
ATOM   3609 N N   . GLY B 1 177 ? 6.31850   3.12139   8.43174   1.000 5.86145  ? 179 GLY B N   1 
ATOM   3610 C CA  . GLY B 1 177 ? 7.68283   3.60736   8.41098   1.000 5.29993  ? 179 GLY B CA  1 
ATOM   3611 C C   . GLY B 1 177 ? 8.74893   2.55128   8.24202   1.000 3.95620  ? 179 GLY B C   1 
ATOM   3612 O O   . GLY B 1 177 ? 9.93383   2.88874   8.29282   1.000 5.66080  ? 179 GLY B O   1 
ATOM   3613 N N   . ASN B 1 178 ? 8.36984   1.29275   8.03488   1.000 4.38558  ? 180 ASN B N   1 
ATOM   3614 C CA  . ASN B 1 178 ? 9.31731   0.20406   7.85756   1.000 5.00290  ? 180 ASN B CA  1 
ATOM   3615 C C   . ASN B 1 178 ? 9.72597   0.11184   6.39482   1.000 9.14325  ? 180 ASN B C   1 
ATOM   3616 O O   . ASN B 1 178 ? 8.87166   -0.10836  5.51919   1.000 2.69774  ? 180 ASN B O   1 
ATOM   3617 C CB  . ASN B 1 178 ? 8.70776   -1.11894  8.30201   1.000 6.68263  ? 180 ASN B CB  1 
ATOM   3618 C CG  . ASN B 1 178 ? 8.13543   -1.05173  9.68912   1.000 8.27248  ? 180 ASN B CG  1 
ATOM   3619 O OD1 . ASN B 1 178 ? 8.86785   -0.89209  10.65699  1.000 6.91667  ? 180 ASN B OD1 1 
ATOM   3620 N ND2 . ASN B 1 178 ? 6.81324   -1.18663  9.79693   1.000 7.98577  ? 180 ASN B ND2 1 
ATOM   3621 N N   . PHE B 1 179 ? 11.03115  0.25124   6.13671   1.000 4.07896  ? 181 PHE B N   1 
ATOM   3622 C CA  . PHE B 1 179 ? 11.52247  0.14772   4.76567   1.000 4.86347  ? 181 PHE B CA  1 
ATOM   3623 C C   . PHE B 1 179 ? 11.21335  -1.22226  4.18487   1.000 1.61523  ? 181 PHE B C   1 
ATOM   3624 O O   . PHE B 1 179 ? 11.18889  -2.22813  4.89708   1.000 0.00008  ? 181 PHE B O   1 
ATOM   3625 C CB  . PHE B 1 179 ? 13.03723  0.40501   4.69654   1.000 1.98472  ? 181 PHE B CB  1 
ATOM   3626 C CG  . PHE B 1 179 ? 13.37958  1.75537   4.13529   1.000 2.43069  ? 181 PHE B CG  1 
ATOM   3627 C CD1 . PHE B 1 179 ? 13.28126  2.00309   2.78390   1.000 1.34468  ? 181 PHE B CD1 1 
ATOM   3628 C CD2 . PHE B 1 179 ? 13.72718  2.79124   4.97960   1.000 4.64538  ? 181 PHE B CD2 1 
ATOM   3629 C CE1 . PHE B 1 179 ? 13.53853  3.24313   2.28223   1.000 3.04086  ? 181 PHE B CE1 1 
ATOM   3630 C CE2 . PHE B 1 179 ? 13.99660  4.03528   4.49073   1.000 4.33554  ? 181 PHE B CE2 1 
ATOM   3631 C CZ  . PHE B 1 179 ? 13.90258  4.26964   3.13763   1.000 4.14119  ? 181 PHE B CZ  1 
ATOM   3632 N N   . TYR B 1 180 ? 10.96691  -1.25145  2.87622   1.000 0.79207  ? 182 TYR B N   1 
ATOM   3633 C CA  . TYR B 1 180 ? 11.06046  -2.48462  2.10851   1.000 3.17462  ? 182 TYR B CA  1 
ATOM   3634 C C   . TYR B 1 180 ? 12.48512  -2.58752  1.57759   1.000 2.22193  ? 182 TYR B C   1 
ATOM   3635 O O   . TYR B 1 180 ? 12.97990  -1.65136  0.94054   1.000 2.35207  ? 182 TYR B O   1 
ATOM   3636 C CB  . TYR B 1 180 ? 10.08450  -2.49947  0.92967   1.000 6.22352  ? 182 TYR B CB  1 
ATOM   3637 C CG  . TYR B 1 180 ? 8.60174   -2.50552  1.23966   1.000 3.39513  ? 182 TYR B CG  1 
ATOM   3638 C CD1 . TYR B 1 180 ? 7.91172   -3.70497  1.47603   1.000 4.61272  ? 182 TYR B CD1 1 
ATOM   3639 C CD2 . TYR B 1 180 ? 7.87371   -1.32294  1.23672   1.000 3.26477  ? 182 TYR B CD2 1 
ATOM   3640 C CE1 . TYR B 1 180 ? 6.52831   -3.70534  1.72102   1.000 7.00188  ? 182 TYR B CE1 1 
ATOM   3641 C CE2 . TYR B 1 180 ? 6.50077   -1.31851  1.48044   1.000 4.28215  ? 182 TYR B CE2 1 
ATOM   3642 C CZ  . TYR B 1 180 ? 5.81888   -2.51001  1.72482   1.000 8.15851  ? 182 TYR B CZ  1 
ATOM   3643 O OH  . TYR B 1 180 ? 4.42880   -2.49768  1.95546   1.000 5.21893  ? 182 TYR B OH  1 
ATOM   3644 N N   . GLY B 1 181 ? 13.14927  -3.70497  1.84411   1.000 4.44773  ? 183 GLY B N   1 
ATOM   3645 C CA  . GLY B 1 181 ? 14.51680  -3.88309  1.38091   1.000 5.33321  ? 183 GLY B CA  1 
ATOM   3646 C C   . GLY B 1 181 ? 15.56679  -3.24825  2.27722   1.000 4.38404  ? 183 GLY B C   1 
ATOM   3647 O O   . GLY B 1 181 ? 15.25201  -2.44199  3.16163   1.000 2.33452  ? 183 GLY B O   1 
ATOM   3648 N N   . PRO B 1 182 ? 16.86506  -3.59423  2.04188   1.000 5.89113  ? 184 PRO B N   1 
ATOM   3649 C CA  . PRO B 1 182 ? 17.95565  -3.19170  2.95431   1.000 5.55709  ? 184 PRO B CA  1 
ATOM   3650 C C   . PRO B 1 182 ? 18.47249  -1.78558  2.66685   1.000 9.95332  ? 184 PRO B C   1 
ATOM   3651 O O   . PRO B 1 182 ? 19.66424  -1.57242  2.36230   1.000 6.36967  ? 184 PRO B O   1 
ATOM   3652 C CB  . PRO B 1 182 ? 19.01462  -4.26846  2.68496   1.000 4.84491  ? 184 PRO B CB  1 
ATOM   3653 C CG  . PRO B 1 182 ? 18.87015  -4.55146  1.22816   1.000 7.40326  ? 184 PRO B CG  1 
ATOM   3654 C CD  . PRO B 1 182 ? 17.36754  -4.43596  0.93522   1.000 6.92814  ? 184 PRO B CD  1 
ATOM   3655 N N   . PHE B 1 183 ? 17.56774  -0.81087  2.75542   1.000 5.42173  ? 185 PHE B N   1 
ATOM   3656 C CA  . PHE B 1 183 ? 17.82765  0.56576   2.36255   1.000 5.39231  ? 185 PHE B CA  1 
ATOM   3657 C C   . PHE B 1 183 ? 17.64299  1.49525   3.55518   1.000 5.09747  ? 185 PHE B C   1 
ATOM   3658 O O   . PHE B 1 183 ? 16.91238  1.17786   4.50053   1.000 8.41088  ? 185 PHE B O   1 
ATOM   3659 C CB  . PHE B 1 183 ? 16.91249  0.95925   1.19446   1.000 5.07281  ? 185 PHE B CB  1 
ATOM   3660 C CG  . PHE B 1 183 ? 17.00250  0.00495   0.03717   1.000 5.54356  ? 185 PHE B CG  1 
ATOM   3661 C CD1 . PHE B 1 183 ? 18.22122  -0.21703  -0.59492  1.000 5.72234  ? 185 PHE B CD1 1 
ATOM   3662 C CD2 . PHE B 1 183 ? 15.90494  -0.70154  -0.38474  1.000 2.72163  ? 185 PHE B CD2 1 
ATOM   3663 C CE1 . PHE B 1 183 ? 18.32666  -1.10971  -1.62914  1.000 7.37319  ? 185 PHE B CE1 1 
ATOM   3664 C CE2 . PHE B 1 183 ? 15.99503  -1.58473  -1.42892  1.000 5.38250  ? 185 PHE B CE2 1 
ATOM   3665 C CZ  . PHE B 1 183 ? 17.21616  -1.79106  -2.06067  1.000 6.76785  ? 185 PHE B CZ  1 
ATOM   3666 N N   . VAL B 1 184 ? 18.32857  2.64112   3.52030   1.000 3.64529  ? 186 VAL B N   1 
ATOM   3667 C CA  . VAL B 1 184 ? 18.26339  3.61810   4.59831   1.000 3.11333  ? 186 VAL B CA  1 
ATOM   3668 C C   . VAL B 1 184 ? 18.00963  4.99023   3.99370   1.000 5.20496  ? 186 VAL B C   1 
ATOM   3669 O O   . VAL B 1 184 ? 18.39377  5.26691   2.84995   1.000 5.10606  ? 186 VAL B O   1 
ATOM   3670 C CB  . VAL B 1 184 ? 19.54143  3.60975   5.48907   1.000 8.32111  ? 186 VAL B CB  1 
ATOM   3671 C CG1 . VAL B 1 184 ? 19.67480  2.25742   6.21741   1.000 7.28272  ? 186 VAL B CG1 1 
ATOM   3672 C CG2 . VAL B 1 184 ? 20.82590  3.94128   4.68490   1.000 4.21897  ? 186 VAL B CG2 1 
ATOM   3673 N N   . ASP B 1 185 ? 17.32232  5.84711   4.75851   1.000 6.91621  ? 187 ASP B N   1 
ATOM   3674 C CA  . ASP B 1 185 ? 16.96145  7.17903   4.26907   1.000 6.56399  ? 187 ASP B CA  1 
ATOM   3675 C C   . ASP B 1 185 ? 18.11245  8.14016   4.57074   1.000 8.11764  ? 187 ASP B C   1 
ATOM   3676 O O   . ASP B 1 185 ? 18.05531  9.02474   5.42449   1.000 12.01014 ? 187 ASP B O   1 
ATOM   3677 C CB  . ASP B 1 185 ? 15.61600  7.64359   4.83229   1.000 8.56611  ? 187 ASP B CB  1 
ATOM   3678 C CG  . ASP B 1 185 ? 15.49332  7.52233   6.35592   1.000 9.20426  ? 187 ASP B CG  1 
ATOM   3679 O OD1 . ASP B 1 185 ? 16.40679  7.00082   7.02846   1.000 8.97144  ? 187 ASP B OD1 1 
ATOM   3680 O OD2 . ASP B 1 185 ? 14.43146  7.95410   6.88083   1.000 9.30272  ? 187 ASP B OD2 1 
ATOM   3681 N N   . ARG B 1 186 ? 19.15445  7.97353   3.76622   1.000 8.38947  ? 188 ARG B N   1 
ATOM   3682 C CA  . ARG B 1 186 ? 20.44880  8.59364   3.95066   1.000 14.46640 ? 188 ARG B CA  1 
ATOM   3683 C C   . ARG B 1 186 ? 21.08456  8.76092   2.57446   1.000 12.80095 ? 188 ARG B C   1 
ATOM   3684 O O   . ARG B 1 186 ? 20.83949  7.95835   1.66954   1.000 11.87112 ? 188 ARG B O   1 
ATOM   3685 C CB  . ARG B 1 186 ? 21.30612  7.70018   4.86222   1.000 14.85306 ? 188 ARG B CB  1 
ATOM   3686 C CG  . ARG B 1 186 ? 22.34001  8.39235   5.65239   1.000 19.27454 ? 188 ARG B CG  1 
ATOM   3687 C CD  . ARG B 1 186 ? 22.45517  7.80314   7.05008   1.000 21.13506 ? 188 ARG B CD  1 
ATOM   3688 N NE  . ARG B 1 186 ? 23.20538  6.54669   7.13107   1.000 19.03689 ? 188 ARG B NE  1 
ATOM   3689 C CZ  . ARG B 1 186 ? 22.70532  5.41110   7.62450   1.000 15.53585 ? 188 ARG B CZ  1 
ATOM   3690 N NH1 . ARG B 1 186 ? 21.44496  5.37861   8.05304   1.000 19.33806 ? 188 ARG B NH1 1 
ATOM   3691 N NH2 . ARG B 1 186 ? 23.45236  4.30697   7.69100   1.000 10.86875 ? 188 ARG B NH2 1 
ATOM   3692 N N   . GLN B 1 187 ? 21.89628  9.80637   2.41299   1.000 13.55760 ? 189 GLN B N   1 
ATOM   3693 C CA  . GLN B 1 187 ? 22.69827  9.96403   1.19824   1.000 11.61242 ? 189 GLN B CA  1 
ATOM   3694 C C   . GLN B 1 187 ? 23.91888  9.05491   1.35059   1.000 19.42618 ? 189 GLN B C   1 
ATOM   3695 O O   . GLN B 1 187 ? 24.92745  9.41250   1.96391   1.000 15.01141 ? 189 GLN B O   1 
ATOM   3696 C CB  . GLN B 1 187 ? 23.08555  11.42135  0.97643   1.000 10.74318 ? 189 GLN B CB  1 
ATOM   3697 N N   . THR B 1 188 ? 23.79013  7.84176   0.81456   1.000 22.56711 ? 190 THR B N   1 
ATOM   3698 C CA  . THR B 1 188 ? 24.76494  6.76829   0.93309   1.000 21.00057 ? 190 THR B CA  1 
ATOM   3699 C C   . THR B 1 188 ? 24.88279  6.08793   -0.42231  1.000 24.94196 ? 190 THR B C   1 
ATOM   3700 O O   . THR B 1 188 ? 24.06411  6.29645   -1.31711  1.000 29.52832 ? 190 THR B O   1 
ATOM   3701 C CB  . THR B 1 188 ? 24.36061  5.74396   2.00796   1.000 27.93219 ? 190 THR B CB  1 
ATOM   3702 O OG1 . THR B 1 188 ? 25.50313  4.94994   2.37316   1.000 40.10344 ? 190 THR B OG1 1 
ATOM   3703 C CG2 . THR B 1 188 ? 23.26888  4.82721   1.48924   1.000 22.67581 ? 190 THR B CG2 1 
ATOM   3704 N N   . ALA B 1 189 ? 25.92093  5.27939   -0.58731  1.000 24.01207 ? 191 ALA B N   1 
ATOM   3705 C CA  . ALA B 1 189 ? 26.07663  4.50966   -1.81943  1.000 27.07919 ? 191 ALA B CA  1 
ATOM   3706 C C   . ALA B 1 189 ? 25.43957  3.14842   -1.59340  1.000 30.42300 ? 191 ALA B C   1 
ATOM   3707 O O   . ALA B 1 189 ? 26.10398  2.18544   -1.22279  1.000 47.62226 ? 191 ALA B O   1 
ATOM   3708 C CB  . ALA B 1 189 ? 27.54295  4.39285   -2.21247  1.000 27.50684 ? 191 ALA B CB  1 
ATOM   3709 N N   . GLN B 1 190 ? 24.12845  3.07512   -1.78300  1.000 19.59048 ? 192 GLN B N   1 
ATOM   3710 C CA  . GLN B 1 190 ? 23.40061  1.81775   -1.71175  1.000 18.26336 ? 192 GLN B CA  1 
ATOM   3711 C C   . GLN B 1 190 ? 22.83077  1.48631   -3.08322  1.000 14.56967 ? 192 GLN B C   1 
ATOM   3712 O O   . GLN B 1 190 ? 22.45547  2.38216   -3.84995  1.000 14.18972 ? 192 GLN B O   1 
ATOM   3713 C CB  . GLN B 1 190 ? 22.27125  1.87055   -0.68172  1.000 17.24966 ? 192 GLN B CB  1 
ATOM   3714 C CG  . GLN B 1 190 ? 21.29652  3.00613   -0.89734  1.000 17.59340 ? 192 GLN B CG  1 
ATOM   3715 C CD  . GLN B 1 190 ? 20.43602  3.25035   0.33358   1.000 14.18077 ? 192 GLN B CD  1 
ATOM   3716 O OE1 . GLN B 1 190 ? 20.47053  2.47220   1.28344   1.000 7.37206  ? 192 GLN B OE1 1 
ATOM   3717 N NE2 . GLN B 1 190 ? 19.66514  4.33506   0.31956   1.000 15.65589 ? 192 GLN B NE2 1 
ATOM   3718 N N   . ALA B 1 191 ? 22.78901  0.18970   -3.38940  1.000 11.34089 ? 193 ALA B N   1 
ATOM   3719 C CA  . ALA B 1 191 ? 22.35132  -0.29256  -4.68909  1.000 18.93328 ? 193 ALA B CA  1 
ATOM   3720 C C   . ALA B 1 191 ? 21.39211  -1.45884  -4.50676  1.000 18.69825 ? 193 ALA B C   1 
ATOM   3721 O O   . ALA B 1 191 ? 21.45317  -2.18639  -3.51186  1.000 15.95520 ? 193 ALA B O   1 
ATOM   3722 C CB  . ALA B 1 191 ? 23.54236  -0.72517  -5.56674  1.000 10.23185 ? 193 ALA B CB  1 
ATOM   3723 N N   . ALA B 1 192 ? 20.49914  -1.61997  -5.48057  1.000 17.25660 ? 194 ALA B N   1 
ATOM   3724 C CA  . ALA B 1 192 ? 19.60897  -2.76685  -5.49579  1.000 16.24755 ? 194 ALA B CA  1 
ATOM   3725 C C   . ALA B 1 192 ? 20.40975  -4.04711  -5.68791  1.000 19.60185 ? 194 ALA B C   1 
ATOM   3726 O O   . ALA B 1 192 ? 21.40187  -4.07447  -6.42539  1.000 19.42831 ? 194 ALA B O   1 
ATOM   3727 C CB  . ALA B 1 192 ? 18.57282  -2.62061  -6.61340  1.000 16.93417 ? 194 ALA B CB  1 
ATOM   3728 N N   . GLY B 1 193 ? 19.97846  -5.11373  -5.00068  1.000 22.92326 ? 195 GLY B N   1 
ATOM   3729 C CA  . GLY B 1 193 ? 20.54850  -6.42437  -5.22325  1.000 20.13177 ? 195 GLY B CA  1 
ATOM   3730 C C   . GLY B 1 193 ? 20.05165  -7.05637  -6.51627  1.000 21.83134 ? 195 GLY B C   1 
ATOM   3731 O O   . GLY B 1 193 ? 19.17401  -6.53120  -7.20511  1.000 17.55966 ? 195 GLY B O   1 
ATOM   3732 N N   . THR B 1 194 ? 20.64108  -8.20642  -6.84251  1.000 23.11826 ? 196 THR B N   1 
ATOM   3733 C CA  . THR B 1 194 ? 20.23733  -8.94894  -8.02871  1.000 25.62422 ? 196 THR B CA  1 
ATOM   3734 C C   . THR B 1 194 ? 18.73866  -9.23772  -7.99689  1.000 22.03981 ? 196 THR B C   1 
ATOM   3735 O O   . THR B 1 194 ? 18.17542  -9.58623  -6.95663  1.000 22.13481 ? 196 THR B O   1 
ATOM   3736 C CB  . THR B 1 194 ? 21.03673  -10.25009 -8.12691  1.000 22.82465 ? 196 THR B CB  1 
ATOM   3737 O OG1 . THR B 1 194 ? 20.55646  -11.02033 -9.23551  1.000 38.23423 ? 196 THR B OG1 1 
ATOM   3738 C CG2 . THR B 1 194 ? 20.89738  -11.05418 -6.85721  1.000 19.01792 ? 196 THR B CG2 1 
ATOM   3739 N N   . ASP B 1 195 ? 18.08779  -9.06970  -9.14082  1.000 26.75033 ? 197 ASP B N   1 
ATOM   3740 C CA  . ASP B 1 195 ? 16.63414  -9.11446  -9.22272  1.000 24.23410 ? 197 ASP B CA  1 
ATOM   3741 C C   . ASP B 1 195 ? 16.19709  -10.34916 -10.00187 1.000 24.62403 ? 197 ASP B C   1 
ATOM   3742 O O   . ASP B 1 195 ? 16.53031  -10.49654 -11.18221 1.000 31.64792 ? 197 ASP B O   1 
ATOM   3743 C CB  . ASP B 1 195 ? 16.08455  -7.84981  -9.88159  1.000 19.52664 ? 197 ASP B CB  1 
ATOM   3744 C CG  . ASP B 1 195 ? 14.56345  -7.71889  -9.71629  1.000 21.46303 ? 197 ASP B CG  1 
ATOM   3745 O OD1 . ASP B 1 195 ? 14.00520  -8.26793  -8.73332  1.000 15.50723 ? 197 ASP B OD1 1 
ATOM   3746 O OD2 . ASP B 1 195 ? 13.94001  -7.04609  -10.55562 1.000 15.04525 ? 197 ASP B OD2 1 
ATOM   3747 N N   . THR B 1 196 ? 15.43782  -11.21931 -9.35255  1.000 21.01529 ? 198 THR B N   1 
ATOM   3748 C CA  . THR B 1 196 ? 14.88654  -12.38583 -10.02041 1.000 21.85425 ? 198 THR B CA  1 
ATOM   3749 C C   . THR B 1 196 ? 13.54144  -12.05427 -10.65405 1.000 18.99301 ? 198 THR B C   1 
ATOM   3750 O O   . THR B 1 196 ? 12.82141  -11.15820 -10.20391 1.000 21.72734 ? 198 THR B O   1 
ATOM   3751 C CB  . THR B 1 196 ? 14.72269  -13.54460 -9.04096  1.000 20.88241 ? 198 THR B CB  1 
ATOM   3752 O OG1 . THR B 1 196 ? 13.74884  -13.19354 -8.04904  1.000 22.42290 ? 198 THR B OG1 1 
ATOM   3753 C CG2 . THR B 1 196 ? 16.04633  -13.84941 -8.36590  1.000 16.99217 ? 198 THR B CG2 1 
ATOM   3754 N N   . THR B 1 197 ? 13.21762  -12.78649 -11.71546 1.000 16.06462 ? 199 THR B N   1 
ATOM   3755 C CA  . THR B 1 197 ? 11.92854  -12.66274 -12.38080 1.000 12.32472 ? 199 THR B CA  1 
ATOM   3756 C C   . THR B 1 197 ? 10.86795  -13.43036 -11.59534 1.000 15.18956 ? 199 THR B C   1 
ATOM   3757 O O   . THR B 1 197 ? 11.14267  -14.49975 -11.03917 1.000 12.93758 ? 199 THR B O   1 
ATOM   3758 C CB  . THR B 1 197 ? 12.02453  -13.18648 -13.81493 1.000 15.72131 ? 199 THR B CB  1 
ATOM   3759 O OG1 . THR B 1 197 ? 12.93669  -12.37280 -14.56240 1.000 11.21746 ? 199 THR B OG1 1 
ATOM   3760 C CG2 . THR B 1 197 ? 10.65839  -13.14668 -14.51260 1.000 11.69577 ? 199 THR B CG2 1 
ATOM   3761 N N   . ILE B 1 198 ? 9.65653   -12.87238 -11.53597 1.000 15.33395 ? 200 ILE B N   1 
ATOM   3762 C CA  . ILE B 1 198 ? 8.60295   -13.38644 -10.66604 1.000 9.49759  ? 200 ILE B CA  1 
ATOM   3763 C C   . ILE B 1 198 ? 7.86000   -14.47764 -11.43099 1.000 11.60760 ? 200 ILE B C   1 
ATOM   3764 O O   . ILE B 1 198 ? 6.92061   -14.20146 -12.18165 1.000 11.51215 ? 200 ILE B O   1 
ATOM   3765 C CB  . ILE B 1 198 ? 7.66470   -12.27383 -10.19982 1.000 12.28836 ? 200 ILE B CB  1 
ATOM   3766 C CG1 . ILE B 1 198 ? 8.47392   -11.09467 -9.65331  1.000 13.50963 ? 200 ILE B CG1 1 
ATOM   3767 C CG2 . ILE B 1 198 ? 6.67398   -12.80828 -9.17596  1.000 7.38057  ? 200 ILE B CG2 1 
ATOM   3768 C CD1 . ILE B 1 198 ? 7.75626   -9.75493  -9.69759  1.000 11.21705 ? 200 ILE B CD1 1 
ATOM   3769 N N   . THR B 1 199 ? 8.24237   -15.73277 -11.17021 1.000 13.37084 ? 201 THR B N   1 
ATOM   3770 C CA  . THR B 1 199 ? 7.81755   -16.86790 -11.98858 1.000 16.52883 ? 201 THR B CA  1 
ATOM   3771 C C   . THR B 1 199 ? 6.30311   -17.07869 -11.96441 1.000 15.89237 ? 201 THR B C   1 
ATOM   3772 O O   . THR B 1 199 ? 5.69102   -17.35227 -13.00812 1.000 10.38109 ? 201 THR B O   1 
ATOM   3773 C CB  . THR B 1 199 ? 8.54364   -18.12097 -11.51067 1.000 12.14755 ? 201 THR B CB  1 
ATOM   3774 O OG1 . THR B 1 199 ? 9.94456   -17.84886 -11.50598 1.000 11.44560 ? 201 THR B OG1 1 
ATOM   3775 C CG2 . THR B 1 199 ? 8.25912   -19.29622 -12.43744 1.000 16.06782 ? 201 THR B CG2 1 
ATOM   3776 N N   . VAL B 1 200 ? 5.68155   -16.96580 -10.78680 1.000 13.57967 ? 202 VAL B N   1 
ATOM   3777 C CA  . VAL B 1 200 ? 4.23509   -17.14756 -10.69838 1.000 12.06992 ? 202 VAL B CA  1 
ATOM   3778 C C   . VAL B 1 200 ? 3.48967   -16.07126 -11.49161 1.000 12.96521 ? 202 VAL B C   1 
ATOM   3779 O O   . VAL B 1 200 ? 2.39893   -16.32511 -12.02750 1.000 9.13277  ? 202 VAL B O   1 
ATOM   3780 C CB  . VAL B 1 200 ? 3.79080   -17.18511 -9.21987  1.000 13.71789 ? 202 VAL B CB  1 
ATOM   3781 C CG1 . VAL B 1 200 ? 4.09595   -15.86010 -8.53355  1.000 8.73593  ? 202 VAL B CG1 1 
ATOM   3782 C CG2 . VAL B 1 200 ? 2.29641   -17.54694 -9.10990  1.000 8.41506  ? 202 VAL B CG2 1 
ATOM   3783 N N   . ASN B 1 201 ? 4.05248   -14.86005 -11.58103 1.000 8.70108  ? 203 ASN B N   1 
ATOM   3784 C CA  . ASN B 1 201 ? 3.40289   -13.81460 -12.36197 1.000 9.97990  ? 203 ASN B CA  1 
ATOM   3785 C C   . ASN B 1 201 ? 3.56980   -14.05385 -13.85820 1.000 8.01553  ? 203 ASN B C   1 
ATOM   3786 O O   . ASN B 1 201 ? 2.64951   -13.77147 -14.63126 1.000 7.01813  ? 203 ASN B O   1 
ATOM   3787 C CB  . ASN B 1 201 ? 3.94238   -12.43492 -11.97190 1.000 9.69285  ? 203 ASN B CB  1 
ATOM   3788 C CG  . ASN B 1 201 ? 3.42139   -11.95145 -10.60681 1.000 9.24582  ? 203 ASN B CG  1 
ATOM   3789 O OD1 . ASN B 1 201 ? 2.63148   -12.62570 -9.94064  1.000 7.47222  ? 203 ASN B OD1 1 
ATOM   3790 N ND2 . ASN B 1 201 ? 3.87188   -10.77915 -10.19717 1.000 6.99271  ? 203 ASN B ND2 1 
ATOM   3791 N N   . VAL B 1 202 ? 4.72982   -14.57028 -14.28408 1.000 8.23620  ? 204 VAL B N   1 
ATOM   3792 C CA  . VAL B 1 202 ? 4.92251   -14.89313 -15.69785 1.000 8.72897  ? 204 VAL B CA  1 
ATOM   3793 C C   . VAL B 1 202 ? 3.91676   -15.94635 -16.13467 1.000 7.70803  ? 204 VAL B C   1 
ATOM   3794 O O   . VAL B 1 202 ? 3.28434   -15.82695 -17.18697 1.000 7.82772  ? 204 VAL B O   1 
ATOM   3795 C CB  . VAL B 1 202 ? 6.36447   -15.36343 -15.97467 1.000 3.96640  ? 204 VAL B CB  1 
ATOM   3796 C CG1 . VAL B 1 202 ? 6.47369   -15.88104 -17.42045 1.000 3.28745  ? 204 VAL B CG1 1 
ATOM   3797 C CG2 . VAL B 1 202 ? 7.34337   -14.24581 -15.75450 1.000 7.06957  ? 204 VAL B CG2 1 
ATOM   3798 N N   . LEU B 1 203 ? 3.78050   -17.00413 -15.33702 1.000 6.67288  ? 205 LEU B N   1 
ATOM   3799 C CA  . LEU B 1 203 ? 2.81895   -18.05884 -15.62513 1.000 10.12148 ? 205 LEU B CA  1 
ATOM   3800 C C   . LEU B 1 203 ? 1.39793   -17.50699 -15.69881 1.000 11.78645 ? 205 LEU B C   1 
ATOM   3801 O O   . LEU B 1 203 ? 0.65213   -17.80850 -16.63877 1.000 9.43095  ? 205 LEU B O   1 
ATOM   3802 C CB  . LEU B 1 203 ? 2.93401   -19.15229 -14.56194 1.000 9.99823  ? 205 LEU B CB  1 
ATOM   3803 C CG  . LEU B 1 203 ? 4.24742   -19.93804 -14.63439 1.000 9.60035  ? 205 LEU B CG  1 
ATOM   3804 C CD1 . LEU B 1 203 ? 4.54554   -20.59807 -13.29353 1.000 9.15510  ? 205 LEU B CD1 1 
ATOM   3805 C CD2 . LEU B 1 203 ? 4.17451   -20.98038 -15.74267 1.000 6.21353  ? 205 LEU B CD2 1 
ATOM   3806 N N   . ALA B 1 204 ? 1.02360   -16.67060 -14.72538 1.000 8.78854  ? 206 ALA B N   1 
ATOM   3807 C CA  . ALA B 1 204 ? -0.27665  -16.01102 -14.74240 1.000 9.35549  ? 206 ALA B CA  1 
ATOM   3808 C C   . ALA B 1 204 ? -0.50117  -15.26030 -16.04789 1.000 12.63155 ? 206 ALA B C   1 
ATOM   3809 O O   . ALA B 1 204 ? -1.59144  -15.31711 -16.62862 1.000 12.20321 ? 206 ALA B O   1 
ATOM   3810 C CB  . ALA B 1 204 ? -0.39017  -15.05442 -13.55319 1.000 7.24887  ? 206 ALA B CB  1 
ATOM   3811 N N   . TRP B 1 205 ? 0.52470   -14.54989 -16.52026 1.000 9.08702  ? 207 TRP B N   1 
ATOM   3812 C CA  . TRP B 1 205 ? 0.42134   -13.77598 -17.75228 1.000 9.96655  ? 207 TRP B CA  1 
ATOM   3813 C C   . TRP B 1 205 ? 0.29208   -14.67550 -18.97829 1.000 12.17657 ? 207 TRP B C   1 
ATOM   3814 O O   . TRP B 1 205 ? -0.38824  -14.31086 -19.94609 1.000 9.89429  ? 207 TRP B O   1 
ATOM   3815 C CB  . TRP B 1 205 ? 1.63498   -12.86138 -17.85504 1.000 11.36798 ? 207 TRP B CB  1 
ATOM   3816 C CG  . TRP B 1 205 ? 1.77973   -12.06790 -19.11113 1.000 13.60415 ? 207 TRP B CG  1 
ATOM   3817 C CD1 . TRP B 1 205 ? 1.07938   -10.94726 -19.46779 1.000 10.34413 ? 207 TRP B CD1 1 
ATOM   3818 C CD2 . TRP B 1 205 ? 2.73238   -12.29563 -20.15528 1.000 11.74042 ? 207 TRP B CD2 1 
ATOM   3819 N NE1 . TRP B 1 205 ? 1.53633   -10.47131 -20.67379 1.000 13.86237 ? 207 TRP B NE1 1 
ATOM   3820 C CE2 . TRP B 1 205 ? 2.54081   -11.28633 -21.12322 1.000 11.46226 ? 207 TRP B CE2 1 
ATOM   3821 C CE3 . TRP B 1 205 ? 3.70699   -13.26728 -20.37829 1.000 9.30641  ? 207 TRP B CE3 1 
ATOM   3822 C CZ2 . TRP B 1 205 ? 3.29002   -11.22165 -22.29035 1.000 17.02704 ? 207 TRP B CZ2 1 
ATOM   3823 C CZ3 . TRP B 1 205 ? 4.46115   -13.19589 -21.53687 1.000 16.38271 ? 207 TRP B CZ3 1 
ATOM   3824 C CH2 . TRP B 1 205 ? 4.24884   -12.17950 -22.47687 1.000 19.33649 ? 207 TRP B CH2 1 
ATOM   3825 N N   . LEU B 1 206 ? 0.91354   -15.85533 -18.94865 1.000 10.06131 ? 208 LEU B N   1 
ATOM   3826 C CA  . LEU B 1 206 ? 0.71428   -16.81734 -20.02457 1.000 10.88005 ? 208 LEU B CA  1 
ATOM   3827 C C   . LEU B 1 206 ? -0.72360  -17.33245 -20.02958 1.000 14.50508 ? 208 LEU B C   1 
ATOM   3828 O O   . LEU B 1 206 ? -1.31979  -17.51098 -21.09691 1.000 13.58146 ? 208 LEU B O   1 
ATOM   3829 C CB  . LEU B 1 206 ? 1.71919   -17.96839 -19.89421 1.000 10.04030 ? 208 LEU B CB  1 
ATOM   3830 C CG  . LEU B 1 206 ? 3.20970   -17.66243 -20.11040 1.000 14.39719 ? 208 LEU B CG  1 
ATOM   3831 C CD1 . LEU B 1 206 ? 4.08562   -18.81663 -19.64142 1.000 10.80812 ? 208 LEU B CD1 1 
ATOM   3832 C CD2 . LEU B 1 206 ? 3.52273   -17.32184 -21.56856 1.000 13.34840 ? 208 LEU B CD2 1 
ATOM   3833 N N   . TYR B 1 207 ? -1.30857  -17.54446 -18.84353 1.000 13.76669 ? 209 TYR B N   1 
ATOM   3834 C CA  . TYR B 1 207 ? -2.71151  -17.94035 -18.77002 1.000 14.56123 ? 209 TYR B CA  1 
ATOM   3835 C C   . TYR B 1 207 ? -3.62346  -16.84069 -19.29787 1.000 20.25965 ? 209 TYR B C   1 
ATOM   3836 O O   . TYR B 1 207 ? -4.62686  -17.12429 -19.96318 1.000 16.45140 ? 209 TYR B O   1 
ATOM   3837 C CB  . TYR B 1 207 ? -3.10229  -18.28998 -17.33571 1.000 14.64849 ? 209 TYR B CB  1 
ATOM   3838 C CG  . TYR B 1 207 ? -2.68221  -19.67414 -16.87691 1.000 21.81201 ? 209 TYR B CG  1 
ATOM   3839 C CD1 . TYR B 1 207 ? -3.40946  -20.80153 -17.23872 1.000 20.11408 ? 209 TYR B CD1 1 
ATOM   3840 C CD2 . TYR B 1 207 ? -1.57629  -19.84680 -16.05483 1.000 16.63552 ? 209 TYR B CD2 1 
ATOM   3841 C CE1 . TYR B 1 207 ? -3.03757  -22.06490 -16.80733 1.000 21.04380 ? 209 TYR B CE1 1 
ATOM   3842 C CE2 . TYR B 1 207 ? -1.19056  -21.10602 -15.62114 1.000 19.84551 ? 209 TYR B CE2 1 
ATOM   3843 C CZ  . TYR B 1 207 ? -1.92444  -22.21229 -15.99651 1.000 25.26193 ? 209 TYR B CZ  1 
ATOM   3844 O OH  . TYR B 1 207 ? -1.54221  -23.46441 -15.55635 1.000 18.73591 ? 209 TYR B OH  1 
ATOM   3845 N N   . ALA B 1 208 ? -3.31086  -15.58080 -18.97974 1.000 13.44493 ? 210 ALA B N   1 
ATOM   3846 C CA  . ALA B 1 208 ? -4.02996  -14.46466 -19.58275 1.000 15.37485 ? 210 ALA B CA  1 
ATOM   3847 C C   . ALA B 1 208 ? -3.92056  -14.48709 -21.10601 1.000 22.01654 ? 210 ALA B C   1 
ATOM   3848 O O   . ALA B 1 208 ? -4.86727  -14.11026 -21.80644 1.000 24.42934 ? 210 ALA B O   1 
ATOM   3849 C CB  . ALA B 1 208 ? -3.50664  -13.14509 -19.02882 1.000 11.30788 ? 210 ALA B CB  1 
ATOM   3850 N N   . ALA B 1 209 ? -2.77608  -14.92992 -21.63868 1.000 21.06483 ? 211 ALA B N   1 
ATOM   3851 C CA  . ALA B 1 209 ? -2.60496  -15.00326 -23.08980 1.000 23.36482 ? 211 ALA B CA  1 
ATOM   3852 C C   . ALA B 1 209 ? -3.49431  -16.08074 -23.70238 1.000 23.14572 ? 211 ALA B C   1 
ATOM   3853 O O   . ALA B 1 209 ? -4.17600  -15.84334 -24.70684 1.000 19.79298 ? 211 ALA B O   1 
ATOM   3854 C CB  . ALA B 1 209 ? -1.13979  -15.26500 -23.43514 1.000 15.12064 ? 211 ALA B CB  1 
ATOM   3855 N N   . VAL B 1 210 ? -3.48221  -17.28236 -23.12015 1.000 25.13557 ? 212 VAL B N   1 
ATOM   3856 C CA  . VAL B 1 210 ? -4.35969  -18.35378 -23.58696 1.000 21.56663 ? 212 VAL B CA  1 
ATOM   3857 C C   . VAL B 1 210 ? -5.82061  -17.92408 -23.49930 1.000 28.02147 ? 212 VAL B C   1 
ATOM   3858 O O   . VAL B 1 210 ? -6.63056  -18.23370 -24.38072 1.000 29.51968 ? 212 VAL B O   1 
ATOM   3859 C CB  . VAL B 1 210 ? -4.09863  -19.63966 -22.77899 1.000 18.71565 ? 212 VAL B CB  1 
ATOM   3860 C CG1 . VAL B 1 210 ? -5.17666  -20.67560 -23.05329 1.000 21.64579 ? 212 VAL B CG1 1 
ATOM   3861 C CG2 . VAL B 1 210 ? -2.71541  -20.19382 -23.08548 1.000 21.93232 ? 212 VAL B CG2 1 
ATOM   3862 N N   . ILE B 1 211 ? -6.17714  -17.19996 -22.43716 1.000 23.06671 ? 213 ILE B N   1 
ATOM   3863 C CA  . ILE B 1 211 ? -7.55251  -16.75876 -22.24658 1.000 20.45549 ? 213 ILE B CA  1 
ATOM   3864 C C   . ILE B 1 211 ? -7.98068  -15.83234 -23.37351 1.000 27.71831 ? 213 ILE B C   1 
ATOM   3865 O O   . ILE B 1 211 ? -9.14545  -15.84321 -23.79142 1.000 25.40250 ? 213 ILE B O   1 
ATOM   3866 C CB  . ILE B 1 211 ? -7.68911  -16.09908 -20.86282 1.000 17.75667 ? 213 ILE B CB  1 
ATOM   3867 C CG1 . ILE B 1 211 ? -7.77445  -17.17255 -19.78796 1.000 16.73825 ? 213 ILE B CG1 1 
ATOM   3868 C CG2 . ILE B 1 211 ? -8.88689  -15.16310 -20.79715 1.000 20.78868 ? 213 ILE B CG2 1 
ATOM   3869 C CD1 . ILE B 1 211 ? -7.78192  -16.60517 -18.39944 1.000 22.51393 ? 213 ILE B CD1 1 
ATOM   3870 N N   . ASN B 1 212 ? -7.05520  -15.03184 -23.89620 1.000 24.12904 ? 214 ASN B N   1 
ATOM   3871 C CA  . ASN B 1 212 ? -7.32390  -14.28406 -25.11755 1.000 24.85993 ? 214 ASN B CA  1 
ATOM   3872 C C   . ASN B 1 212 ? -6.96087  -15.15030 -26.31824 1.000 20.06069 ? 214 ASN B C   1 
ATOM   3873 O O   . ASN B 1 212 ? -7.20298  -16.35882 -26.30735 1.000 30.23488 ? 214 ASN B O   1 
ATOM   3874 C CB  . ASN B 1 212 ? -6.56317  -12.95791 -25.10726 1.000 20.24022 ? 214 ASN B CB  1 
ATOM   3875 C CG  . ASN B 1 212 ? -7.02893  -12.03762 -23.99022 1.000 23.84150 ? 214 ASN B CG  1 
ATOM   3876 O OD1 . ASN B 1 212 ? -6.33630  -11.85803 -22.99331 1.000 37.99189 ? 214 ASN B OD1 1 
ATOM   3877 N ND2 . ASN B 1 212 ? -8.21260  -11.46171 -24.14510 1.000 24.82504 ? 214 ASN B ND2 1 
ATOM   3878 N N   . GLY B 1 213 ? -6.37539  -14.57800 -27.35297 1.000 22.41048 ? 215 GLY B N   1 
ATOM   3879 C CA  . GLY B 1 213 ? -6.10041  -15.38757 -28.52665 1.000 27.37126 ? 215 GLY B CA  1 
ATOM   3880 C C   . GLY B 1 213 ? -4.88458  -16.29656 -28.47529 1.000 32.93496 ? 215 GLY B C   1 
ATOM   3881 O O   . GLY B 1 213 ? -4.94084  -17.42397 -28.97638 1.000 28.41406 ? 215 GLY B O   1 
ATOM   3882 N N   . ASP B 1 214 ? -3.79556  -15.83027 -27.85414 1.000 29.54775 ? 216 ASP B N   1 
ATOM   3883 C CA  . ASP B 1 214 ? -2.46190  -16.38940 -28.07889 1.000 26.31611 ? 216 ASP B CA  1 
ATOM   3884 C C   . ASP B 1 214 ? -2.31250  -17.77671 -27.45564 1.000 31.70154 ? 216 ASP B C   1 
ATOM   3885 O O   . ASP B 1 214 ? -2.45086  -17.94586 -26.23878 1.000 38.68680 ? 216 ASP B O   1 
ATOM   3886 C CB  . ASP B 1 214 ? -1.40475  -15.44010 -27.52332 1.000 30.24010 ? 216 ASP B CB  1 
ATOM   3887 C CG  . ASP B 1 214 ? -0.75544  -14.59967 -28.59891 1.000 37.84631 ? 216 ASP B CG  1 
ATOM   3888 O OD1 . ASP B 1 214 ? -0.23738  -15.17752 -29.57739 1.000 49.73361 ? 216 ASP B OD1 1 
ATOM   3889 O OD2 . ASP B 1 214 ? -0.75820  -13.35907 -28.47350 1.000 31.82684 ? 216 ASP B OD2 1 
ATOM   3890 N N   . ARG B 1 215 ? -1.97303  -18.75777 -28.29051 1.000 28.98927 ? 217 ARG B N   1 
ATOM   3891 C CA  . ARG B 1 215 ? -1.92967  -20.15102 -27.87966 1.000 20.57569 ? 217 ARG B CA  1 
ATOM   3892 C C   . ARG B 1 215 ? -0.72058  -20.88630 -28.43541 1.000 25.87557 ? 217 ARG B C   1 
ATOM   3893 O O   . ARG B 1 215 ? -0.59312  -22.09204 -28.20313 1.000 28.83919 ? 217 ARG B O   1 
ATOM   3894 C CB  . ARG B 1 215 ? -3.20880  -20.87442 -28.32910 1.000 30.42633 ? 217 ARG B CB  1 
ATOM   3895 C CG  . ARG B 1 215 ? -3.88241  -21.65129 -27.23621 1.000 34.19040 ? 217 ARG B CG  1 
ATOM   3896 C CD  . ARG B 1 215 ? -4.81836  -22.72769 -27.76800 1.000 28.54141 ? 217 ARG B CD  1 
ATOM   3897 N NE  . ARG B 1 215 ? -5.45405  -23.43970 -26.65730 1.000 32.95164 ? 217 ARG B NE  1 
ATOM   3898 C CZ  . ARG B 1 215 ? -6.43011  -22.93551 -25.90508 1.000 36.63889 ? 217 ARG B CZ  1 
ATOM   3899 N NH1 . ARG B 1 215 ? -6.94628  -23.64671 -24.90594 1.000 42.74463 ? 217 ARG B NH1 1 
ATOM   3900 N NH2 . ARG B 1 215 ? -6.89615  -21.71713 -26.15017 1.000 39.37366 ? 217 ARG B NH2 1 
ATOM   3901 N N   . TRP B 1 216 ? 0.17806   -20.20070 -29.14208 1.000 20.40992 ? 218 TRP B N   1 
ATOM   3902 C CA  . TRP B 1 216 ? 1.19799   -20.88347 -29.92074 1.000 21.58088 ? 218 TRP B CA  1 
ATOM   3903 C C   . TRP B 1 216 ? 2.27694   -21.51495 -29.05673 1.000 24.27649 ? 218 TRP B C   1 
ATOM   3904 O O   . TRP B 1 216 ? 2.93636   -22.45373 -29.51338 1.000 21.75326 ? 218 TRP B O   1 
ATOM   3905 C CB  . TRP B 1 216 ? 1.82535   -19.90611 -30.91909 1.000 15.32950 ? 218 TRP B CB  1 
ATOM   3906 C CG  . TRP B 1 216 ? 2.52452   -18.72847 -30.29931 1.000 27.19594 ? 218 TRP B CG  1 
ATOM   3907 C CD1 . TRP B 1 216 ? 2.00761   -17.47726 -30.10113 1.000 25.75449 ? 218 TRP B CD1 1 
ATOM   3908 C CD2 . TRP B 1 216 ? 3.87824   -18.68224 -29.80964 1.000 26.29298 ? 218 TRP B CD2 1 
ATOM   3909 N NE1 . TRP B 1 216 ? 2.95047   -16.66074 -29.51632 1.000 27.94157 ? 218 TRP B NE1 1 
ATOM   3910 C CE2 . TRP B 1 216 ? 4.10688   -17.37471 -29.33320 1.000 26.07004 ? 218 TRP B CE2 1 
ATOM   3911 C CE3 . TRP B 1 216 ? 4.91371   -19.61733 -29.73011 1.000 24.08880 ? 218 TRP B CE3 1 
ATOM   3912 C CZ2 . TRP B 1 216 ? 5.32720   -16.98320 -28.78096 1.000 29.26722 ? 218 TRP B CZ2 1 
ATOM   3913 C CZ3 . TRP B 1 216 ? 6.12794   -19.22452 -29.17846 1.000 30.51124 ? 218 TRP B CZ3 1 
ATOM   3914 C CH2 . TRP B 1 216 ? 6.32318   -17.92107 -28.71412 1.000 27.20660 ? 218 TRP B CH2 1 
ATOM   3915 N N   . PHE B 1 217 ? 2.48197   -21.01725 -27.83356 1.000 23.26964 ? 219 PHE B N   1 
ATOM   3916 C CA  . PHE B 1 217 ? 3.54619   -21.50869 -26.96299 1.000 20.56968 ? 219 PHE B CA  1 
ATOM   3917 C C   . PHE B 1 217 ? 3.17217   -22.79490 -26.24816 1.000 23.23967 ? 219 PHE B C   1 
ATOM   3918 O O   . PHE B 1 217 ? 4.04939   -23.42807 -25.64948 1.000 26.53786 ? 219 PHE B O   1 
ATOM   3919 C CB  . PHE B 1 217 ? 3.91839   -20.44709 -25.92181 1.000 20.85052 ? 219 PHE B CB  1 
ATOM   3920 C CG  . PHE B 1 217 ? 2.72727   -19.82163 -25.25322 1.000 20.61793 ? 219 PHE B CG  1 
ATOM   3921 C CD1 . PHE B 1 217 ? 2.13491   -20.42878 -24.14841 1.000 20.85767 ? 219 PHE B CD1 1 
ATOM   3922 C CD2 . PHE B 1 217 ? 2.18600   -18.63792 -25.73871 1.000 18.48316 ? 219 PHE B CD2 1 
ATOM   3923 C CE1 . PHE B 1 217 ? 1.02187   -19.86356 -23.53306 1.000 21.57605 ? 219 PHE B CE1 1 
ATOM   3924 C CE2 . PHE B 1 217 ? 1.07774   -18.06542 -25.13370 1.000 19.08110 ? 219 PHE B CE2 1 
ATOM   3925 C CZ  . PHE B 1 217 ? 0.48735   -18.67941 -24.02961 1.000 19.78601 ? 219 PHE B CZ  1 
ATOM   3926 N N   . LEU B 1 218 ? 1.90100   -23.18325 -26.27959 1.000 22.50719 ? 220 LEU B N   1 
ATOM   3927 C CA  . LEU B 1 218 ? 1.47966   -24.40317 -25.61345 1.000 23.35049 ? 220 LEU B CA  1 
ATOM   3928 C C   . LEU B 1 218 ? 2.10001   -25.61944 -26.29056 1.000 30.36851 ? 220 LEU B C   1 
ATOM   3929 O O   . LEU B 1 218 ? 2.45570   -25.59280 -27.47413 1.000 26.45960 ? 220 LEU B O   1 
ATOM   3930 C CB  . LEU B 1 218 ? -0.03776  -24.51745 -25.62386 1.000 21.36049 ? 220 LEU B CB  1 
ATOM   3931 C CG  . LEU B 1 218 ? -0.80030  -23.37280 -24.94707 1.000 30.88076 ? 220 LEU B CG  1 
ATOM   3932 C CD1 . LEU B 1 218 ? -2.28886  -23.68445 -24.87083 1.000 19.08535 ? 220 LEU B CD1 1 
ATOM   3933 C CD2 . LEU B 1 218 ? -0.23786  -23.07365 -23.55867 1.000 26.03223 ? 220 LEU B CD2 1 
ATOM   3934 N N   . ASN B 1 219 ? 2.23862   -26.69194 -25.51602 1.000 31.21109 ? 221 ASN B N   1 
ATOM   3935 C CA  . ASN B 1 219 ? 2.80793   -27.93145 -26.01532 1.000 22.43665 ? 221 ASN B CA  1 
ATOM   3936 C C   . ASN B 1 219 ? 2.10477   -29.09644 -25.33209 1.000 25.33966 ? 221 ASN B C   1 
ATOM   3937 O O   . ASN B 1 219 ? 1.25477   -28.91166 -24.45454 1.000 24.34565 ? 221 ASN B O   1 
ATOM   3938 C CB  . ASN B 1 219 ? 4.32666   -27.96001 -25.81719 1.000 23.69932 ? 221 ASN B CB  1 
ATOM   3939 C CG  . ASN B 1 219 ? 4.74180   -28.06016 -24.35362 1.000 23.59709 ? 221 ASN B CG  1 
ATOM   3940 O OD1 . ASN B 1 219 ? 3.94045   -27.88860 -23.42477 1.000 23.69542 ? 221 ASN B OD1 1 
ATOM   3941 N ND2 . ASN B 1 219 ? 6.01663   -28.31577 -24.14733 1.000 27.77527 ? 221 ASN B ND2 1 
ATOM   3942 N N   . ARG B 1 220 ? 2.44930   -30.30581 -25.76643 1.000 21.39121 ? 222 ARG B N   1 
ATOM   3943 C CA  . ARG B 1 220 ? 1.85600   -31.52526 -25.23145 1.000 19.31305 ? 222 ARG B CA  1 
ATOM   3944 C C   . ARG B 1 220 ? 2.55805   -32.03068 -23.97735 1.000 19.55306 ? 222 ARG B C   1 
ATOM   3945 O O   . ARG B 1 220 ? 2.17300   -33.08077 -23.45511 1.000 19.71187 ? 222 ARG B O   1 
ATOM   3946 C CB  . ARG B 1 220 ? 1.89690   -32.63115 -26.28547 1.000 17.84925 ? 222 ARG B CB  1 
ATOM   3947 C CG  . ARG B 1 220 ? 3.31420   -33.19587 -26.46244 1.000 19.96696 ? 222 ARG B CG  1 
ATOM   3948 C CD  . ARG B 1 220 ? 3.26751   -34.52915 -27.15556 1.000 18.92207 ? 222 ARG B CD  1 
ATOM   3949 N NE  . ARG B 1 220 ? 2.96075   -34.33450 -28.56235 1.000 20.33652 ? 222 ARG B NE  1 
ATOM   3950 C CZ  . ARG B 1 220 ? 2.27102   -35.19285 -29.29648 1.000 21.77294 ? 222 ARG B CZ  1 
ATOM   3951 N NH1 . ARG B 1 220 ? 1.82169   -36.31447 -28.74654 1.000 19.62629 ? 222 ARG B NH1 1 
ATOM   3952 N NH2 . ARG B 1 220 ? 2.04497   -34.92644 -30.57941 1.000 28.33182 ? 222 ARG B NH2 1 
ATOM   3953 N N   . PHE B 1 221 ? 3.58168   -31.33233 -23.50000 1.000 16.65422 ? 223 PHE B N   1 
ATOM   3954 C CA  . PHE B 1 221 ? 4.50010   -31.87773 -22.51494 1.000 25.56786 ? 223 PHE B CA  1 
ATOM   3955 C C   . PHE B 1 221 ? 4.20842   -31.35820 -21.10799 1.000 26.36508 ? 223 PHE B C   1 
ATOM   3956 O O   . PHE B 1 221 ? 3.34916   -30.50240 -20.88523 1.000 24.06723 ? 223 PHE B O   1 
ATOM   3957 C CB  . PHE B 1 221 ? 5.93519   -31.55990 -22.91820 1.000 17.40289 ? 223 PHE B CB  1 
ATOM   3958 C CG  . PHE B 1 221 ? 6.33261   -32.15153 -24.23746 1.000 20.28485 ? 223 PHE B CG  1 
ATOM   3959 C CD1 . PHE B 1 221 ? 6.34860   -33.52783 -24.41764 1.000 17.48692 ? 223 PHE B CD1 1 
ATOM   3960 C CD2 . PHE B 1 221 ? 6.69329   -31.33829 -25.29875 1.000 16.34782 ? 223 PHE B CD2 1 
ATOM   3961 C CE1 . PHE B 1 221 ? 6.71761   -34.07578 -25.63463 1.000 16.44389 ? 223 PHE B CE1 1 
ATOM   3962 C CE2 . PHE B 1 221 ? 7.07324   -31.88489 -26.50962 1.000 17.91690 ? 223 PHE B CE2 1 
ATOM   3963 C CZ  . PHE B 1 221 ? 7.08499   -33.25021 -26.67849 1.000 17.53461 ? 223 PHE B CZ  1 
ATOM   3964 N N   . THR B 1 222 ? 4.94704   -31.90365 -20.14404 1.000 27.89581 ? 224 THR B N   1 
ATOM   3965 C CA  . THR B 1 222 ? 4.85874   -31.51273 -18.74354 1.000 28.62851 ? 224 THR B CA  1 
ATOM   3966 C C   . THR B 1 222 ? 6.24139   -31.68568 -18.12751 1.000 26.62436 ? 224 THR B C   1 
ATOM   3967 O O   . THR B 1 222 ? 7.02907   -32.53017 -18.56667 1.000 25.29504 ? 224 THR B O   1 
ATOM   3968 C CB  . THR B 1 222 ? 3.79719   -32.34123 -17.99099 1.000 23.33668 ? 224 THR B CB  1 
ATOM   3969 O OG1 . THR B 1 222 ? 2.49429   -31.98258 -18.45599 1.000 33.07421 ? 224 THR B OG1 1 
ATOM   3970 C CG2 . THR B 1 222 ? 3.84810   -32.11607 -16.48701 1.000 24.48207 ? 224 THR B CG2 1 
ATOM   3971 N N   . THR B 1 223 ? 6.54336   -30.85806 -17.13224 1.000 29.00907 ? 225 THR B N   1 
ATOM   3972 C CA  . THR B 1 223 ? 7.77644   -30.95917 -16.37267 1.000 26.44477 ? 225 THR B CA  1 
ATOM   3973 C C   . THR B 1 223 ? 7.44853   -31.32125 -14.93111 1.000 34.25102 ? 225 THR B C   1 
ATOM   3974 O O   . THR B 1 223 ? 6.28477   -31.33860 -14.51495 1.000 34.08568 ? 225 THR B O   1 
ATOM   3975 C CB  . THR B 1 223 ? 8.57631   -29.64793 -16.43417 1.000 31.69380 ? 225 THR B CB  1 
ATOM   3976 O OG1 . THR B 1 223 ? 8.58877   -29.16625 -17.78023 1.000 41.36295 ? 225 THR B OG1 1 
ATOM   3977 C CG2 . THR B 1 223 ? 10.01645  -29.86558 -16.01587 1.000 29.25903 ? 225 THR B CG2 1 
ATOM   3978 N N   . THR B 1 224 ? 8.50157   -31.65318 -14.18953 1.000 30.24118 ? 226 THR B N   1 
ATOM   3979 C CA  . THR B 1 224 ? 8.47275   -31.77332 -12.74367 1.000 32.95675 ? 226 THR B CA  1 
ATOM   3980 C C   . THR B 1 224 ? 8.84422   -30.43594 -12.10962 1.000 29.39532 ? 226 THR B C   1 
ATOM   3981 O O   . THR B 1 224 ? 9.54618   -29.61352 -12.70822 1.000 24.50981 ? 226 THR B O   1 
ATOM   3982 C CB  . THR B 1 224 ? 9.45084   -32.85452 -12.27924 1.000 31.61949 ? 226 THR B CB  1 
ATOM   3983 O OG1 . THR B 1 224 ? 10.79305  -32.36118 -12.38601 1.000 30.51749 ? 226 THR B OG1 1 
ATOM   3984 C CG2 . THR B 1 224 ? 9.31713   -34.10038 -13.14286 1.000 31.58087 ? 226 THR B CG2 1 
ATOM   3985 N N   . LEU B 1 225 ? 8.36625   -30.22604 -10.88191 1.000 29.95304 ? 227 LEU B N   1 
ATOM   3986 C CA  . LEU B 1 225 ? 8.72371   -29.01497 -10.15297 1.000 23.57661 ? 227 LEU B CA  1 
ATOM   3987 C C   . LEU B 1 225 ? 10.23829  -28.85090 -10.06325 1.000 28.27039 ? 227 LEU B C   1 
ATOM   3988 O O   . LEU B 1 225 ? 10.76176  -27.74183 -10.22865 1.000 27.62910 ? 227 LEU B O   1 
ATOM   3989 C CB  . LEU B 1 225 ? 8.08722   -29.05062 -8.76721  1.000 28.34221 ? 227 LEU B CB  1 
ATOM   3990 C CG  . LEU B 1 225 ? 7.93812   -27.70466 -8.07540  1.000 28.47673 ? 227 LEU B CG  1 
ATOM   3991 C CD1 . LEU B 1 225 ? 7.43172   -26.67813 -9.07219  1.000 27.30658 ? 227 LEU B CD1 1 
ATOM   3992 C CD2 . LEU B 1 225 ? 6.99358   -27.82907 -6.89118  1.000 28.09062 ? 227 LEU B CD2 1 
ATOM   3993 N N   . ASN B 1 226 ? 10.96487  -29.96051 -9.88217  1.000 26.54122 ? 228 ASN B N   1 
ATOM   3994 C CA  . ASN B 1 226 ? 12.41209  -29.90146 -9.70146  1.000 23.18195 ? 228 ASN B CA  1 
ATOM   3995 C C   . ASN B 1 226 ? 13.15945  -29.67131 -11.00768 1.000 24.98694 ? 228 ASN B C   1 
ATOM   3996 O O   . ASN B 1 226 ? 14.16203  -28.94638 -11.02463 1.000 23.14917 ? 228 ASN B O   1 
ATOM   3997 C CB  . ASN B 1 226 ? 12.89940  -31.18147 -9.03349  1.000 24.92717 ? 228 ASN B CB  1 
ATOM   3998 C CG  . ASN B 1 226 ? 11.99387  -31.60807 -7.90593  1.000 35.76966 ? 228 ASN B CG  1 
ATOM   3999 O OD1 . ASN B 1 226 ? 10.76425  -31.54916 -8.03354  1.000 37.74005 ? 228 ASN B OD1 1 
ATOM   4000 N ND2 . ASN B 1 226 ? 12.58396  -32.02206 -6.78784  1.000 28.98124 ? 228 ASN B ND2 1 
ATOM   4001 N N   . ASP B 1 227 ? 12.71862  -30.28676 -12.10854 1.000 25.12222 ? 229 ASP B N   1 
ATOM   4002 C CA  . ASP B 1 227 ? 13.40302  -30.03174 -13.37209 1.000 24.52311 ? 229 ASP B CA  1 
ATOM   4003 C C   . ASP B 1 227 ? 13.19638  -28.59351 -13.82725 1.000 21.99086 ? 229 ASP B C   1 
ATOM   4004 O O   . ASP B 1 227 ? 14.11005  -27.98979 -14.40480 1.000 30.37410 ? 229 ASP B O   1 
ATOM   4005 C CB  . ASP B 1 227 ? 12.93777  -31.01253 -14.45321 1.000 35.57418 ? 229 ASP B CB  1 
ATOM   4006 C CG  . ASP B 1 227 ? 13.31802  -32.45620 -14.14217 1.000 41.34433 ? 229 ASP B CG  1 
ATOM   4007 O OD1 . ASP B 1 227 ? 14.52937  -32.76076 -14.05928 1.000 45.82104 ? 229 ASP B OD1 1 
ATOM   4008 O OD2 . ASP B 1 227 ? 12.39903  -33.28780 -13.97706 1.000 41.09421 ? 229 ASP B OD2 1 
ATOM   4009 N N   . PHE B 1 228 ? 12.02028  -28.02228 -13.56036 1.000 25.81899 ? 230 PHE B N   1 
ATOM   4010 C CA  . PHE B 1 228 ? 11.79420  -26.62320 -13.89875 1.000 22.32651 ? 230 PHE B CA  1 
ATOM   4011 C C   . PHE B 1 228 ? 12.64815  -25.70409 -13.03119 1.000 19.10766 ? 230 PHE B C   1 
ATOM   4012 O O   . PHE B 1 228 ? 13.27518  -24.76474 -13.53289 1.000 19.48486 ? 230 PHE B O   1 
ATOM   4013 C CB  . PHE B 1 228 ? 10.32024  -26.27240 -13.75099 1.000 22.18713 ? 230 PHE B CB  1 
ATOM   4014 C CG  . PHE B 1 228 ? 10.04104  -24.81689 -13.96298 1.000 27.02144 ? 230 PHE B CG  1 
ATOM   4015 C CD1 . PHE B 1 228 ? 9.89015   -24.30977 -15.24262 1.000 22.54894 ? 230 PHE B CD1 1 
ATOM   4016 C CD2 . PHE B 1 228 ? 9.96605   -23.94728 -12.88571 1.000 22.56596 ? 230 PHE B CD2 1 
ATOM   4017 C CE1 . PHE B 1 228 ? 9.65945   -22.96807 -15.44163 1.000 22.23686 ? 230 PHE B CE1 1 
ATOM   4018 C CE2 . PHE B 1 228 ? 9.73660   -22.60983 -13.07419 1.000 22.45230 ? 230 PHE B CE2 1 
ATOM   4019 C CZ  . PHE B 1 228 ? 9.58028   -22.11303 -14.35344 1.000 27.19307 ? 230 PHE B CZ  1 
ATOM   4020 N N   . ASN B 1 229 ? 12.68226  -25.95816 -11.72213 1.000 19.16031 ? 231 ASN B N   1 
ATOM   4021 C CA  . ASN B 1 229 ? 13.46016  -25.10728 -10.82872 1.000 16.44979 ? 231 ASN B CA  1 
ATOM   4022 C C   . ASN B 1 229 ? 14.94870  -25.17105 -11.15383 1.000 21.37384 ? 231 ASN B C   1 
ATOM   4023 O O   . ASN B 1 229 ? 15.67819  -24.19626 -10.92925 1.000 21.80926 ? 231 ASN B O   1 
ATOM   4024 C CB  . ASN B 1 229 ? 13.17475  -25.48900 -9.37820  1.000 14.27504 ? 231 ASN B CB  1 
ATOM   4025 C CG  . ASN B 1 229 ? 11.86318  -24.88806 -8.87346  1.000 25.98531 ? 231 ASN B CG  1 
ATOM   4026 O OD1 . ASN B 1 229 ? 11.44372  -23.81959 -9.33516  1.000 23.88833 ? 231 ASN B OD1 1 
ATOM   4027 N ND2 . ASN B 1 229 ? 11.20439  -25.57427 -7.93503  1.000 25.28938 ? 231 ASN B ND2 1 
ATOM   4028 N N   . LEU B 1 230 ? 15.40608  -26.27708 -11.73910 1.000 17.94246 ? 232 LEU B N   1 
ATOM   4029 C CA  . LEU B 1 230 ? 16.76042  -26.30564 -12.27234 1.000 20.54782 ? 232 LEU B CA  1 
ATOM   4030 C C   . LEU B 1 230 ? 16.92705  -25.31489 -13.42108 1.000 24.45908 ? 232 LEU B C   1 
ATOM   4031 O O   . LEU B 1 230 ? 17.94103  -24.61147 -13.49514 1.000 22.57811 ? 232 LEU B O   1 
ATOM   4032 C CB  . LEU B 1 230 ? 17.11008  -27.72045 -12.71549 1.000 27.11220 ? 232 LEU B CB  1 
ATOM   4033 C CG  . LEU B 1 230 ? 18.53364  -28.15921 -12.40609 1.000 25.50888 ? 232 LEU B CG  1 
ATOM   4034 C CD1 . LEU B 1 230 ? 19.03656  -27.49470 -11.12828 1.000 28.47039 ? 232 LEU B CD1 1 
ATOM   4035 C CD2 . LEU B 1 230 ? 18.56225  -29.66129 -12.27524 1.000 29.80845 ? 232 LEU B CD2 1 
ATOM   4036 N N   . VAL B 1 231 ? 15.94538  -25.23249 -14.32438 1.000 23.49084 ? 233 VAL B N   1 
ATOM   4037 C CA  . VAL B 1 231 ? 16.03074  -24.24317 -15.39662 1.000 23.58406 ? 233 VAL B CA  1 
ATOM   4038 C C   . VAL B 1 231 ? 15.82944  -22.83814 -14.83932 1.000 23.19431 ? 233 VAL B C   1 
ATOM   4039 O O   . VAL B 1 231 ? 16.49870  -21.88462 -15.25967 1.000 18.89500 ? 233 VAL B O   1 
ATOM   4040 C CB  . VAL B 1 231 ? 15.01326  -24.56147 -16.50882 1.000 29.86755 ? 233 VAL B CB  1 
ATOM   4041 C CG1 . VAL B 1 231 ? 15.32148  -23.75488 -17.75517 1.000 23.13725 ? 233 VAL B CG1 1 
ATOM   4042 C CG2 . VAL B 1 231 ? 15.01509  -26.03915 -16.82354 1.000 28.51620 ? 233 VAL B CG2 1 
ATOM   4043 N N   . ALA B 1 232 ? 14.90229  -22.68942 -13.88624 1.000 21.80137 ? 234 ALA B N   1 
ATOM   4044 C CA  . ALA B 1 232 ? 14.68807  -21.40233 -13.22538 1.000 18.15700 ? 234 ALA B CA  1 
ATOM   4045 C C   . ALA B 1 232 ? 15.99079  -20.82088 -12.67598 1.000 23.19612 ? 234 ALA B C   1 
ATOM   4046 O O   . ALA B 1 232 ? 16.27830  -19.63188 -12.85804 1.000 21.42881 ? 234 ALA B O   1 
ATOM   4047 C CB  . ALA B 1 232 ? 13.66521  -21.56307 -12.10401 1.000 19.68116 ? 234 ALA B CB  1 
ATOM   4048 N N   . MET B 1 233 ? 16.78643  -21.64729 -11.98775 1.000 16.61152 ? 235 MET B N   1 
ATOM   4049 C CA  . MET B 1 233 ? 18.05730  -21.17225 -11.44397 1.000 22.57317 ? 235 MET B CA  1 
ATOM   4050 C C   . MET B 1 233 ? 18.97192  -20.63947 -12.54137 1.000 22.45621 ? 235 MET B C   1 
ATOM   4051 O O   . MET B 1 233 ? 19.58608  -19.57715 -12.38550 1.000 21.01123 ? 235 MET B O   1 
ATOM   4052 C CB  . MET B 1 233 ? 18.74937  -22.29560 -10.67271 1.000 20.83904 ? 235 MET B CB  1 
ATOM   4053 C CG  . MET B 1 233 ? 18.22592  -22.49251 -9.26606  1.000 31.94327 ? 235 MET B CG  1 
ATOM   4054 S SD  . MET B 1 233 ? 19.39300  -23.35396 -8.19407  1.000 50.90101 ? 235 MET B SD  1 
ATOM   4055 C CE  . MET B 1 233 ? 20.86781  -22.35325 -8.42149  1.000 39.10922 ? 235 MET B CE  1 
ATOM   4056 N N   . LYS B 1 234 ? 19.06403  -21.36183 -13.66122 1.000 21.54660 ? 236 LYS B N   1 
ATOM   4057 C CA  . LYS B 1 234 ? 19.89197  -20.92548 -14.78262 1.000 23.29675 ? 236 LYS B CA  1 
ATOM   4058 C C   . LYS B 1 234 ? 19.52635  -19.52217 -15.24639 1.000 24.33211 ? 236 LYS B C   1 
ATOM   4059 O O   . LYS B 1 234 ? 20.40886  -18.69989 -15.52514 1.000 29.70249 ? 236 LYS B O   1 
ATOM   4060 C CB  . LYS B 1 234 ? 19.74450  -21.90603 -15.94694 1.000 32.29757 ? 236 LYS B CB  1 
ATOM   4061 C CG  . LYS B 1 234 ? 20.99577  -22.67500 -16.28670 1.000 36.36334 ? 236 LYS B CG  1 
ATOM   4062 C CD  . LYS B 1 234 ? 20.90319  -23.27234 -17.68290 1.000 39.22627 ? 236 LYS B CD  1 
ATOM   4063 C CE  . LYS B 1 234 ? 21.30986  -22.27000 -18.75434 1.000 39.18093 ? 236 LYS B CE  1 
ATOM   4064 N NZ  . LYS B 1 234 ? 21.68239  -22.97987 -20.00986 1.000 42.09929 ? 236 LYS B NZ  1 
ATOM   4065 N N   . TYR B 1 235 ? 18.22995  -19.23565 -15.35883 1.000 28.19250 ? 237 TYR B N   1 
ATOM   4066 C CA  . TYR B 1 235 ? 17.75786  -17.99380 -15.95399 1.000 22.98736 ? 237 TYR B CA  1 
ATOM   4067 C C   . TYR B 1 235 ? 17.32844  -16.96846 -14.92003 1.000 17.82293 ? 237 TYR B C   1 
ATOM   4068 O O   . TYR B 1 235 ? 16.69069  -15.97703 -15.28230 1.000 20.92497 ? 237 TYR B O   1 
ATOM   4069 C CB  . TYR B 1 235 ? 16.62090  -18.28719 -16.92955 1.000 27.76863 ? 237 TYR B CB  1 
ATOM   4070 C CG  . TYR B 1 235 ? 17.09083  -19.13007 -18.08227 1.000 26.35155 ? 237 TYR B CG  1 
ATOM   4071 C CD1 . TYR B 1 235 ? 17.05215  -20.51838 -18.01529 1.000 29.28989 ? 237 TYR B CD1 1 
ATOM   4072 C CD2 . TYR B 1 235 ? 17.61694  -18.54077 -19.22164 1.000 30.10133 ? 237 TYR B CD2 1 
ATOM   4073 C CE1 . TYR B 1 235 ? 17.50763  -21.29610 -19.06471 1.000 31.29004 ? 237 TYR B CE1 1 
ATOM   4074 C CE2 . TYR B 1 235 ? 18.07682  -19.30673 -20.27481 1.000 31.43769 ? 237 TYR B CE2 1 
ATOM   4075 C CZ  . TYR B 1 235 ? 18.01924  -20.68437 -20.19389 1.000 37.46631 ? 237 TYR B CZ  1 
ATOM   4076 O OH  . TYR B 1 235 ? 18.47595  -21.44651 -21.24995 1.000 41.19960 ? 237 TYR B OH  1 
ATOM   4077 N N   . ASN B 1 236 ? 17.67596  -17.17982 -13.64825 1.000 16.31238 ? 238 ASN B N   1 
ATOM   4078 C CA  . ASN B 1 236 ? 17.44658  -16.19517 -12.59341 1.000 20.76079 ? 238 ASN B CA  1 
ATOM   4079 C C   . ASN B 1 236 ? 15.94782  -15.97570 -12.37565 1.000 20.70056 ? 238 ASN B C   1 
ATOM   4080 O O   . ASN B 1 236 ? 15.48235  -14.85221 -12.19074 1.000 15.46677 ? 238 ASN B O   1 
ATOM   4081 C CB  . ASN B 1 236 ? 18.16956  -14.88301 -12.91443 1.000 22.11815 ? 238 ASN B CB  1 
ATOM   4082 C CG  . ASN B 1 236 ? 18.51545  -14.08106 -11.68080 1.000 28.29655 ? 238 ASN B CG  1 
ATOM   4083 O OD1 . ASN B 1 236 ? 18.73400  -14.62982 -10.60205 1.000 34.26623 ? 238 ASN B OD1 1 
ATOM   4084 N ND2 . ASN B 1 236 ? 18.57350  -12.76416 -11.83842 1.000 30.19078 ? 238 ASN B ND2 1 
ATOM   4085 N N   . TYR B 1 237 ? 15.18558  -17.06289 -12.43207 1.000 15.13223 ? 239 TYR B N   1 
ATOM   4086 C CA  . TYR B 1 237 ? 13.77027  -17.05077 -12.10987 1.000 15.26778 ? 239 TYR B CA  1 
ATOM   4087 C C   . TYR B 1 237 ? 13.57226  -17.54228 -10.68568 1.000 17.04769 ? 239 TYR B C   1 
ATOM   4088 O O   . TYR B 1 237 ? 14.23375  -18.48886 -10.24237 1.000 14.53447 ? 239 TYR B O   1 
ATOM   4089 C CB  . TYR B 1 237 ? 12.97548  -17.93059 -13.07407 1.000 14.20823 ? 239 TYR B CB  1 
ATOM   4090 C CG  . TYR B 1 237 ? 12.42835  -17.20810 -14.28866 1.000 11.29360 ? 239 TYR B CG  1 
ATOM   4091 C CD1 . TYR B 1 237 ? 13.27003  -16.53378 -15.17157 1.000 10.22038 ? 239 TYR B CD1 1 
ATOM   4092 C CD2 . TYR B 1 237 ? 11.05395  -17.21403 -14.55901 1.000 11.41948 ? 239 TYR B CD2 1 
ATOM   4093 C CE1 . TYR B 1 237 ? 12.75227  -15.87284 -16.30049 1.000 10.45170 ? 239 TYR B CE1 1 
ATOM   4094 C CE2 . TYR B 1 237 ? 10.53378  -16.55832 -15.66743 1.000 8.88164  ? 239 TYR B CE2 1 
ATOM   4095 C CZ  . TYR B 1 237 ? 11.38134  -15.89737 -16.53471 1.000 10.49958 ? 239 TYR B CZ  1 
ATOM   4096 O OH  . TYR B 1 237 ? 10.83666  -15.26551 -17.63268 1.000 13.23264 ? 239 TYR B OH  1 
ATOM   4097 N N   . GLU B 1 238 ? 12.66469  -16.88651 -9.97543  1.000 16.17452 ? 240 GLU B N   1 
ATOM   4098 C CA  . GLU B 1 238 ? 12.29172  -17.32376 -8.64474  1.000 14.69942 ? 240 GLU B CA  1 
ATOM   4099 C C   . GLU B 1 238 ? 11.88720  -18.79619 -8.67828  1.000 16.93118 ? 240 GLU B C   1 
ATOM   4100 O O   . GLU B 1 238 ? 11.07674  -19.18543 -9.52697  1.000 12.14875 ? 240 GLU B O   1 
ATOM   4101 C CB  . GLU B 1 238 ? 11.13829  -16.46297 -8.13062  1.000 15.14068 ? 240 GLU B CB  1 
ATOM   4102 C CG  . GLU B 1 238 ? 10.68067  -16.82995 -6.74389  1.000 17.25135 ? 240 GLU B CG  1 
ATOM   4103 C CD  . GLU B 1 238 ? 11.72658  -16.47614 -5.70999  1.000 27.41073 ? 240 GLU B CD  1 
ATOM   4104 O OE1 . GLU B 1 238 ? 12.52256  -15.54691 -5.98218  1.000 13.03099 ? 240 GLU B OE1 1 
ATOM   4105 O OE2 . GLU B 1 238 ? 11.75106  -17.12635 -4.63769  1.000 29.42095 ? 240 GLU B OE2 1 
ATOM   4106 N N   . PRO B 1 239 ? 12.43189  -19.64292 -7.79859  1.000 16.63924 ? 241 PRO B N   1 
ATOM   4107 C CA  . PRO B 1 239 ? 11.95406  -21.02982 -7.74011  1.000 20.36339 ? 241 PRO B CA  1 
ATOM   4108 C C   . PRO B 1 239 ? 10.45601  -21.08455 -7.46891  1.000 19.67624 ? 241 PRO B C   1 
ATOM   4109 O O   . PRO B 1 239 ? 9.90812   -20.27290 -6.71882  1.000 21.13612 ? 241 PRO B O   1 
ATOM   4110 C CB  . PRO B 1 239 ? 12.76842  -21.65294 -6.59570  1.000 16.76405 ? 241 PRO B CB  1 
ATOM   4111 C CG  . PRO B 1 239 ? 13.52277  -20.53865 -5.96215  1.000 18.27663 ? 241 PRO B CG  1 
ATOM   4112 C CD  . PRO B 1 239 ? 13.61983  -19.43579 -6.95507  1.000 16.29796 ? 241 PRO B CD  1 
ATOM   4113 N N   . LEU B 1 240 ? 9.79362   -22.04757 -8.10777  1.000 21.19733 ? 242 LEU B N   1 
ATOM   4114 C CA  . LEU B 1 240 ? 8.34615   -22.19188 -8.02523  1.000 18.08742 ? 242 LEU B CA  1 
ATOM   4115 C C   . LEU B 1 240 ? 7.98231   -23.13461 -6.88857  1.000 16.80710 ? 242 LEU B C   1 
ATOM   4116 O O   . LEU B 1 240 ? 8.56386   -24.21348 -6.75250  1.000 16.09381 ? 242 LEU B O   1 
ATOM   4117 C CB  . LEU B 1 240 ? 7.79070   -22.71347 -9.34533  1.000 14.39095 ? 242 LEU B CB  1 
ATOM   4118 C CG  . LEU B 1 240 ? 6.27817   -22.74959 -9.52450  1.000 16.32755 ? 242 LEU B CG  1 
ATOM   4119 C CD1 . LEU B 1 240 ? 5.75680   -21.35142 -9.77820  1.000 15.95277 ? 242 LEU B CD1 1 
ATOM   4120 C CD2 . LEU B 1 240 ? 5.92173   -23.67323 -10.67565 1.000 16.38243 ? 242 LEU B CD2 1 
ATOM   4121 N N   . THR B 1 241 ? 7.02169   -22.72807 -6.07809  1.000 17.31113 ? 243 THR B N   1 
ATOM   4122 C CA  . THR B 1 241 ? 6.63315   -23.48956 -4.90590  1.000 22.67342 ? 243 THR B CA  1 
ATOM   4123 C C   . THR B 1 241 ? 5.24820   -24.08990 -5.09261  1.000 23.58888 ? 243 THR B C   1 
ATOM   4124 O O   . THR B 1 241 ? 4.47593   -23.68555 -5.96673  1.000 21.33630 ? 243 THR B O   1 
ATOM   4125 C CB  . THR B 1 241 ? 6.63844   -22.61062 -3.64935  1.000 21.67199 ? 243 THR B CB  1 
ATOM   4126 O OG1 . THR B 1 241 ? 5.46286   -21.79012 -3.64387  1.000 18.46715 ? 243 THR B OG1 1 
ATOM   4127 C CG2 . THR B 1 241 ? 7.88842   -21.72538 -3.62525  1.000 19.15576 ? 243 THR B CG2 1 
ATOM   4128 N N   . GLN B 1 242 ? 4.94747   -25.06994 -4.24051  1.000 24.84782 ? 244 GLN B N   1 
ATOM   4129 C CA  . GLN B 1 242 ? 3.60849   -25.64122 -4.20721  1.000 25.27693 ? 244 GLN B CA  1 
ATOM   4130 C C   . GLN B 1 242 ? 2.55664   -24.57582 -3.93106  1.000 29.29057 ? 244 GLN B C   1 
ATOM   4131 O O   . GLN B 1 242 ? 1.41419   -24.70004 -4.38689  1.000 29.73118 ? 244 GLN B O   1 
ATOM   4132 C CB  . GLN B 1 242 ? 3.54483   -26.74543 -3.15249  1.000 26.73784 ? 244 GLN B CB  1 
ATOM   4133 C CG  . GLN B 1 242 ? 2.28614   -27.57454 -3.20323  1.000 27.72770 ? 244 GLN B CG  1 
ATOM   4134 C CD  . GLN B 1 242 ? 1.95589   -28.02654 -4.60463  1.000 28.81215 ? 244 GLN B CD  1 
ATOM   4135 O OE1 . GLN B 1 242 ? 2.74099   -28.72304 -5.24948  1.000 31.39622 ? 244 GLN B OE1 1 
ATOM   4136 N NE2 . GLN B 1 242 ? 0.79308   -27.62672 -5.08851  1.000 25.62532 ? 244 GLN B NE2 1 
ATOM   4137 N N   . ASP B 1 243 ? 2.91955   -23.52051 -3.19666  1.000 27.11199 ? 245 ASP B N   1 
ATOM   4138 C CA  . ASP B 1 243 ? 1.97924   -22.43020 -2.96773  1.000 28.90627 ? 245 ASP B CA  1 
ATOM   4139 C C   . ASP B 1 243 ? 1.66565   -21.69750 -4.26633  1.000 27.80512 ? 245 ASP B C   1 
ATOM   4140 O O   . ASP B 1 243 ? 0.49646   -21.43234 -4.57176  1.000 29.80556 ? 245 ASP B O   1 
ATOM   4141 C CB  . ASP B 1 243 ? 2.53370   -21.46563 -1.92125  1.000 31.30632 ? 245 ASP B CB  1 
ATOM   4142 C CG  . ASP B 1 243 ? 2.32314   -21.96383 -0.50728  1.000 45.20082 ? 245 ASP B CG  1 
ATOM   4143 O OD1 . ASP B 1 243 ? 1.51517   -22.90307 -0.32351  1.000 40.03099 ? 245 ASP B OD1 1 
ATOM   4144 O OD2 . ASP B 1 243 ? 2.96786   -21.41985 0.41941   1.000 50.58486 ? 245 ASP B OD2 1 
ATOM   4145 N N   . HIS B 1 244 ? 2.70161   -21.36170 -5.04289  1.000 28.39831 ? 246 HIS B N   1 
ATOM   4146 C CA  . HIS B 1 244 ? 2.48291   -20.74516 -6.34957  1.000 23.20483 ? 246 HIS B CA  1 
ATOM   4147 C C   . HIS B 1 244 ? 1.58017   -21.60363 -7.22843  1.000 24.15140 ? 246 HIS B C   1 
ATOM   4148 O O   . HIS B 1 244 ? 0.69830   -21.08122 -7.92078  1.000 20.64842 ? 246 HIS B O   1 
ATOM   4149 C CB  . HIS B 1 244 ? 3.81723   -20.50828 -7.04453  1.000 18.18387 ? 246 HIS B CB  1 
ATOM   4150 C CG  . HIS B 1 244 ? 4.73503   -19.59666 -6.29365  1.000 20.50024 ? 246 HIS B CG  1 
ATOM   4151 N ND1 . HIS B 1 244 ? 6.10714   -19.73959 -6.31097  1.000 22.11594 ? 246 HIS B ND1 1 
ATOM   4152 C CD2 . HIS B 1 244 ? 4.47625   -18.52857 -5.50350  1.000 14.43677 ? 246 HIS B CD2 1 
ATOM   4153 C CE1 . HIS B 1 244 ? 6.65357   -18.79706 -5.56235  1.000 21.10511 ? 246 HIS B CE1 1 
ATOM   4154 N NE2 . HIS B 1 244 ? 5.68446   -18.04601 -5.06645  1.000 18.59107 ? 246 HIS B NE2 1 
ATOM   4155 N N   . VAL B 1 245 ? 1.78511   -22.92404 -7.21229  1.000 21.83746 ? 247 VAL B N   1 
ATOM   4156 C CA  . VAL B 1 245 ? 0.96773   -23.81355 -8.03218  1.000 25.82709 ? 247 VAL B CA  1 
ATOM   4157 C C   . VAL B 1 245 ? -0.49031  -23.75815 -7.58923  1.000 23.87643 ? 247 VAL B C   1 
ATOM   4158 O O   . VAL B 1 245 ? -1.39326  -23.57761 -8.41151  1.000 24.31224 ? 247 VAL B O   1 
ATOM   4159 C CB  . VAL B 1 245 ? 1.52227   -25.24960 -7.99239  1.000 23.47124 ? 247 VAL B CB  1 
ATOM   4160 C CG1 . VAL B 1 245 ? 0.64871   -26.17788 -8.81673  1.000 20.66641 ? 247 VAL B CG1 1 
ATOM   4161 C CG2 . VAL B 1 245 ? 2.94854   -25.27332 -8.50196  1.000 20.74434 ? 247 VAL B CG2 1 
ATOM   4162 N N   . ASP B 1 246 ? -0.74140  -23.89278 -6.28094  1.000 27.08708 ? 248 ASP B N   1 
ATOM   4163 C CA  . ASP B 1 246 ? -2.12055  -23.87133 -5.79007  1.000 28.45595 ? 248 ASP B CA  1 
ATOM   4164 C C   . ASP B 1 246 ? -2.81093  -22.55883 -6.14234  1.000 27.20328 ? 248 ASP B C   1 
ATOM   4165 O O   . ASP B 1 246 ? -4.00890  -22.53972 -6.45026  1.000 26.80928 ? 248 ASP B O   1 
ATOM   4166 C CB  . ASP B 1 246 ? -2.16344  -24.08587 -4.27311  1.000 32.79941 ? 248 ASP B CB  1 
ATOM   4167 C CG  . ASP B 1 246 ? -1.47778  -25.37899 -3.82048  1.000 38.63261 ? 248 ASP B CG  1 
ATOM   4168 O OD1 . ASP B 1 246 ? -1.34843  -26.33462 -4.62180  1.000 29.80496 ? 248 ASP B OD1 1 
ATOM   4169 O OD2 . ASP B 1 246 ? -1.07175  -25.43317 -2.63640  1.000 37.41634 ? 248 ASP B OD2 1 
ATOM   4170 N N   . ILE B 1 247 ? -2.06360  -21.45168 -6.11474  1.000 25.99168 ? 249 ILE B N   1 
ATOM   4171 C CA  . ILE B 1 247 ? -2.64795  -20.13278 -6.34674  1.000 20.48458 ? 249 ILE B CA  1 
ATOM   4172 C C   . ILE B 1 247 ? -3.06423  -19.96226 -7.80801  1.000 22.29795 ? 249 ILE B C   1 
ATOM   4173 O O   . ILE B 1 247 ? -4.01833  -19.23274 -8.10504  1.000 25.59047 ? 249 ILE B O   1 
ATOM   4174 C CB  . ILE B 1 247 ? -1.64745  -19.05834 -5.86150  1.000 20.81129 ? 249 ILE B CB  1 
ATOM   4175 C CG1 . ILE B 1 247 ? -1.92028  -18.67382 -4.40481  1.000 25.21474 ? 249 ILE B CG1 1 
ATOM   4176 C CG2 . ILE B 1 247 ? -1.61376  -17.84160 -6.75412  1.000 20.03784 ? 249 ILE B CG2 1 
ATOM   4177 C CD1 . ILE B 1 247 ? -1.54945  -19.75326 -3.38372  1.000 32.31294 ? 249 ILE B CD1 1 
ATOM   4178 N N   . LEU B 1 248 ? -2.38672  -20.64750 -8.73630  1.000 22.76087 ? 250 LEU B N   1 
ATOM   4179 C CA  . LEU B 1 248 ? -2.75298  -20.66002 -10.15082 1.000 21.83991 ? 250 LEU B CA  1 
ATOM   4180 C C   . LEU B 1 248 ? -3.86557  -21.66023 -10.47174 1.000 23.05253 ? 250 LEU B C   1 
ATOM   4181 O O   . LEU B 1 248 ? -4.18918  -21.85329 -11.65369 1.000 22.36880 ? 250 LEU B O   1 
ATOM   4182 C CB  . LEU B 1 248 ? -1.52590  -20.97599 -11.01636 1.000 16.46474 ? 250 LEU B CB  1 
ATOM   4183 C CG  . LEU B 1 248 ? -0.42142  -19.92162 -11.09740 1.000 18.33714 ? 250 LEU B CG  1 
ATOM   4184 C CD1 . LEU B 1 248 ? 0.91743   -20.54933 -11.50365 1.000 12.05227 ? 250 LEU B CD1 1 
ATOM   4185 C CD2 . LEU B 1 248 ? -0.81577  -18.83602 -12.06817 1.000 17.79816 ? 250 LEU B CD2 1 
ATOM   4186 N N   . GLY B 1 249 ? -4.43376  -22.30547 -9.45377  1.000 29.33631 ? 251 GLY B N   1 
ATOM   4187 C CA  . GLY B 1 249 ? -5.49601  -23.27125 -9.62790  1.000 32.04547 ? 251 GLY B CA  1 
ATOM   4188 C C   . GLY B 1 249 ? -6.65377  -22.81649 -10.50281 1.000 24.73435 ? 251 GLY B C   1 
ATOM   4189 O O   . GLY B 1 249 ? -7.00123  -23.47344 -11.48907 1.000 30.78740 ? 251 GLY B O   1 
ATOM   4190 N N   . PRO B 1 250 ? -7.29413  -21.69988 -10.14381 1.000 25.12125 ? 252 PRO B N   1 
ATOM   4191 C CA  . PRO B 1 250 ? -8.42392  -21.21533 -10.95952 1.000 17.75138 ? 252 PRO B CA  1 
ATOM   4192 C C   . PRO B 1 250 ? -8.10673  -21.06965 -12.43588 1.000 30.47333 ? 252 PRO B C   1 
ATOM   4193 O O   . PRO B 1 250 ? -8.89448  -21.51591 -13.28276 1.000 33.31120 ? 252 PRO B O   1 
ATOM   4194 C CB  . PRO B 1 250 ? -8.76619  -19.86446 -10.31285 1.000 21.00267 ? 252 PRO B CB  1 
ATOM   4195 C CG  . PRO B 1 250 ? -7.67701  -19.58454 -9.32670  1.000 27.42095 ? 252 PRO B CG  1 
ATOM   4196 C CD  . PRO B 1 250 ? -7.14084  -20.91186 -8.91410  1.000 24.12573 ? 252 PRO B CD  1 
ATOM   4197 N N   . LEU B 1 251 ? -6.96535  -20.46042 -12.76900 1.000 27.56248 ? 253 LEU B N   1 
ATOM   4198 C CA  . LEU B 1 251 ? -6.57526  -20.30247 -14.16727 1.000 27.07795 ? 253 LEU B CA  1 
ATOM   4199 C C   . LEU B 1 251 ? -6.21958  -21.63735 -14.81759 1.000 28.52917 ? 253 LEU B C   1 
ATOM   4200 O O   . LEU B 1 251 ? -6.44179  -21.81237 -16.02363 1.000 25.48986 ? 253 LEU B O   1 
ATOM   4201 C CB  . LEU B 1 251 ? -5.39390  -19.33280 -14.27520 1.000 24.83896 ? 253 LEU B CB  1 
ATOM   4202 C CG  . LEU B 1 251 ? -5.56050  -17.94599 -13.64932 1.000 25.27686 ? 253 LEU B CG  1 
ATOM   4203 C CD1 . LEU B 1 251 ? -4.21602  -17.22137 -13.63012 1.000 18.98287 ? 253 LEU B CD1 1 
ATOM   4204 C CD2 . LEU B 1 251 ? -6.61539  -17.12742 -14.39174 1.000 16.58003 ? 253 LEU B CD2 1 
ATOM   4205 N N   . SER B 1 252 ? -5.65835  -22.58240 -14.04854 1.000 24.28497 ? 254 SER B N   1 
ATOM   4206 C CA  . SER B 1 252 ? -5.37578  -23.90749 -14.59798 1.000 26.82850 ? 254 SER B CA  1 
ATOM   4207 C C   . SER B 1 252 ? -6.66371  -24.62454 -14.98946 1.000 34.20887 ? 254 SER B C   1 
ATOM   4208 O O   . SER B 1 252 ? -6.70952  -25.32291 -16.01189 1.000 33.80236 ? 254 SER B O   1 
ATOM   4209 C CB  . SER B 1 252 ? -4.58468  -24.74669 -13.59143 1.000 29.45337 ? 254 SER B CB  1 
ATOM   4210 O OG  . SER B 1 252 ? -4.45514  -26.09799 -14.02915 1.000 25.81532 ? 254 SER B OG  1 
ATOM   4211 N N   . ALA B 1 253 ? -7.71459  -24.46785 -14.18213 1.000 27.70533 ? 255 ALA B N   1 
ATOM   4212 C CA  . ALA B 1 253 ? -9.02524  -24.99333 -14.54139 1.000 29.37732 ? 255 ALA B CA  1 
ATOM   4213 C C   . ALA B 1 253 ? -9.53521  -24.34245 -15.82144 1.000 36.61657 ? 255 ALA B C   1 
ATOM   4214 O O   . ALA B 1 253 ? -9.72429  -25.01113 -16.84507 1.000 34.31111 ? 255 ALA B O   1 
ATOM   4215 C CB  . ALA B 1 253 ? -10.00997 -24.76500 -13.39204 1.000 24.57479 ? 255 ALA B CB  1 
ATOM   4216 N N   . GLN B 1 254 ? -9.71427  -23.01978 -15.78880 1.000 32.46623 ? 256 GLN B N   1 
ATOM   4217 C CA  . GLN B 1 254 ? -10.32355 -22.24127 -16.86199 1.000 30.38952 ? 256 GLN B CA  1 
ATOM   4218 C C   . GLN B 1 254 ? -9.73092  -22.50945 -18.24160 1.000 29.39864 ? 256 GLN B C   1 
ATOM   4219 O O   . GLN B 1 254 ? -10.32485 -22.12400 -19.25130 1.000 38.64860 ? 256 GLN B O   1 
ATOM   4220 C CB  . GLN B 1 254 ? -10.20913 -20.74725 -16.54350 1.000 32.84396 ? 256 GLN B CB  1 
ATOM   4221 C CG  . GLN B 1 254 ? -11.27932 -19.88680 -17.21135 1.000 39.34418 ? 256 GLN B CG  1 
ATOM   4222 C CD  . GLN B 1 254 ? -11.02148 -18.39724 -17.05981 1.000 43.35790 ? 256 GLN B CD  1 
ATOM   4223 O OE1 . GLN B 1 254 ? -10.78135 -17.90697 -15.95516 1.000 42.53326 ? 256 GLN B OE1 1 
ATOM   4224 N NE2 . GLN B 1 254 ? -11.06277 -17.66983 -18.17554 1.000 32.64145 ? 256 GLN B NE2 1 
ATOM   4225 N N   . THR B 1 255 ? -8.57053  -23.16281 -18.30977 1.000 30.20419 ? 257 THR B N   1 
ATOM   4226 C CA  . THR B 1 255 ? -7.89286  -23.39726 -19.57685 1.000 29.83307 ? 257 THR B CA  1 
ATOM   4227 C C   . THR B 1 255 ? -7.61979  -24.86257 -19.88545 1.000 30.22657 ? 257 THR B C   1 
ATOM   4228 O O   . THR B 1 255 ? -7.41458  -25.19564 -21.05969 1.000 29.18641 ? 257 THR B O   1 
ATOM   4229 C CB  . THR B 1 255 ? -6.54725  -22.64813 -19.61836 1.000 31.70185 ? 257 THR B CB  1 
ATOM   4230 O OG1 . THR B 1 255 ? -5.57960  -23.35567 -18.82695 1.000 29.56777 ? 257 THR B OG1 1 
ATOM   4231 C CG2 . THR B 1 255 ? -6.70442  -21.22747 -19.09760 1.000 23.40958 ? 257 THR B CG2 1 
ATOM   4232 N N   . GLY B 1 256 ? -7.59611  -25.73944 -18.88482 1.000 27.43991 ? 258 GLY B N   1 
ATOM   4233 C CA  . GLY B 1 256 ? -7.17749  -27.10290 -19.13123 1.000 29.12165 ? 258 GLY B CA  1 
ATOM   4234 C C   . GLY B 1 256 ? -5.68708  -27.27950 -19.33080 1.000 34.15137 ? 258 GLY B C   1 
ATOM   4235 O O   . GLY B 1 256 ? -5.26304  -28.29836 -19.89136 1.000 25.79947 ? 258 GLY B O   1 
ATOM   4236 N N   . ILE B 1 257 ? -4.87739  -26.31507 -18.89606 1.000 25.27919 ? 259 ILE B N   1 
ATOM   4237 C CA  . ILE B 1 257 ? -3.42291  -26.42025 -18.93133 1.000 33.51381 ? 259 ILE B CA  1 
ATOM   4238 C C   . ILE B 1 257 ? -2.92810  -26.40831 -17.49139 1.000 27.63561 ? 259 ILE B C   1 
ATOM   4239 O O   . ILE B 1 257 ? -3.01080  -25.37983 -16.81153 1.000 27.92504 ? 259 ILE B O   1 
ATOM   4240 C CB  . ILE B 1 257 ? -2.77823  -25.28563 -19.73621 1.000 27.54869 ? 259 ILE B CB  1 
ATOM   4241 C CG1 . ILE B 1 257 ? -3.39622  -25.19512 -21.12921 1.000 29.54770 ? 259 ILE B CG1 1 
ATOM   4242 C CG2 . ILE B 1 257 ? -1.26923  -25.48522 -19.81352 1.000 27.83615 ? 259 ILE B CG2 1 
ATOM   4243 C CD1 . ILE B 1 257 ? -3.57291  -23.78395 -21.59170 1.000 33.26799 ? 259 ILE B CD1 1 
ATOM   4244 N N   . ALA B 1 258 ? -2.42268  -27.54211 -17.02337 1.000 22.49953 ? 260 ALA B N   1 
ATOM   4245 C CA  . ALA B 1 258 ? -1.89981  -27.61200 -15.66806 1.000 22.20433 ? 260 ALA B CA  1 
ATOM   4246 C C   . ALA B 1 258 ? -0.57757  -26.86160 -15.56641 1.000 23.58530 ? 260 ALA B C   1 
ATOM   4247 O O   . ALA B 1 258 ? 0.16944   -26.73213 -16.54391 1.000 21.14149 ? 260 ALA B O   1 
ATOM   4248 C CB  . ALA B 1 258 ? -1.71303  -29.06412 -15.24154 1.000 23.28417 ? 260 ALA B CB  1 
ATOM   4249 N N   . VAL B 1 259 ? -0.28749  -26.37092 -14.35963 1.000 24.38080 ? 261 VAL B N   1 
ATOM   4250 C CA  . VAL B 1 259 ? 0.86796   -25.49421 -14.17326 1.000 19.80343 ? 261 VAL B CA  1 
ATOM   4251 C C   . VAL B 1 259 ? 2.12170   -26.13045 -14.75735 1.000 20.43863 ? 261 VAL B C   1 
ATOM   4252 O O   . VAL B 1 259 ? 2.83650   -25.51981 -15.56576 1.000 19.93215 ? 261 VAL B O   1 
ATOM   4253 C CB  . VAL B 1 259 ? 1.05099   -25.15295 -12.68437 1.000 19.27876 ? 261 VAL B CB  1 
ATOM   4254 C CG1 . VAL B 1 259 ? 2.23741   -24.21998 -12.52271 1.000 18.63602 ? 261 VAL B CG1 1 
ATOM   4255 C CG2 . VAL B 1 259 ? -0.22545  -24.54264 -12.11609 1.000 10.68494 ? 261 VAL B CG2 1 
ATOM   4256 N N   . LEU B 1 260 ? 2.38733   -27.38471 -14.38568 1.000 19.92418 ? 262 LEU B N   1 
ATOM   4257 C CA  . LEU B 1 260 ? 3.58307   -28.05916 -14.88449 1.000 22.86683 ? 262 LEU B CA  1 
ATOM   4258 C C   . LEU B 1 260 ? 3.52330   -28.31380 -16.38957 1.000 22.78012 ? 262 LEU B C   1 
ATOM   4259 O O   . LEU B 1 260 ? 4.57353   -28.53931 -17.00427 1.000 21.94458 ? 262 LEU B O   1 
ATOM   4260 C CB  . LEU B 1 260 ? 3.81336   -29.36662 -14.11750 1.000 20.24755 ? 262 LEU B CB  1 
ATOM   4261 C CG  . LEU B 1 260 ? 4.20910   -29.19789 -12.64215 1.000 26.96627 ? 262 LEU B CG  1 
ATOM   4262 C CD1 . LEU B 1 260 ? 4.30215   -30.53912 -11.93028 1.000 29.56567 ? 262 LEU B CD1 1 
ATOM   4263 C CD2 . LEU B 1 260 ? 5.52391   -28.45659 -12.53151 1.000 24.64217 ? 262 LEU B CD2 1 
ATOM   4264 N N   . ASP B 1 261 ? 2.32526   -28.28524 -16.98707 1.000 21.07936 ? 263 ASP B N   1 
ATOM   4265 C CA  . ASP B 1 261 ? 2.20364   -28.25036 -18.44397 1.000 23.64836 ? 263 ASP B CA  1 
ATOM   4266 C C   . ASP B 1 261 ? 2.65725   -26.89759 -18.97788 1.000 17.95909 ? 263 ASP B C   1 
ATOM   4267 O O   . ASP B 1 261 ? 3.53288   -26.82499 -19.84861 1.000 24.72246 ? 263 ASP B O   1 
ATOM   4268 C CB  . ASP B 1 261 ? 0.75019   -28.56539 -18.83551 1.000 27.82892 ? 263 ASP B CB  1 
ATOM   4269 C CG  . ASP B 1 261 ? 0.47957   -28.52603 -20.35401 1.000 28.73852 ? 263 ASP B CG  1 
ATOM   4270 O OD1 . ASP B 1 261 ? 1.40673   -28.46137 -21.20440 1.000 27.51743 ? 263 ASP B OD1 1 
ATOM   4271 O OD2 . ASP B 1 261 ? -0.72464  -28.56392 -20.68772 1.000 27.68640 ? 263 ASP B OD2 1 
ATOM   4272 N N   . MET B 1 262 ? 2.11456   -25.80816 -18.41783 1.000 20.92168 ? 264 MET B N   1 
ATOM   4273 C CA  . MET B 1 262 ? 2.58014   -24.46867 -18.77757 1.000 22.30937 ? 264 MET B CA  1 
ATOM   4274 C C   . MET B 1 262 ? 4.06305   -24.27399 -18.46314 1.000 21.44761 ? 264 MET B C   1 
ATOM   4275 O O   . MET B 1 262 ? 4.76519   -23.55991 -19.19338 1.000 22.59188 ? 264 MET B O   1 
ATOM   4276 C CB  . MET B 1 262 ? 1.73625   -23.41331 -18.05647 1.000 22.94548 ? 264 MET B CB  1 
ATOM   4277 C CG  . MET B 1 262 ? 1.87259   -22.00776 -18.62915 1.000 23.61144 ? 264 MET B CG  1 
ATOM   4278 S SD  . MET B 1 262 ? 0.94277   -21.75686 -20.15880 1.000 21.66382 ? 264 MET B SD  1 
ATOM   4279 C CE  . MET B 1 262 ? -0.69749  -21.47813 -19.49566 1.000 18.09708 ? 264 MET B CE  1 
ATOM   4280 N N   . CYS B 1 263 ? 4.56315   -24.90458 -17.39289 1.000 22.05380 ? 265 CYS B N   1 
ATOM   4281 C CA  . CYS B 1 263 ? 5.98070   -24.77612 -17.06312 1.000 24.31115 ? 265 CYS B CA  1 
ATOM   4282 C C   . CYS B 1 263 ? 6.85552   -25.36555 -18.16017 1.000 21.28932 ? 265 CYS B C   1 
ATOM   4283 O O   . CYS B 1 263 ? 7.91497   -24.81172 -18.48178 1.000 22.26707 ? 265 CYS B O   1 
ATOM   4284 C CB  . CYS B 1 263 ? 6.27474   -25.43844 -15.71555 1.000 26.61454 ? 265 CYS B CB  1 
ATOM   4285 S SG  . CYS B 1 263 ? 5.69217   -24.48417 -14.27371 1.000 21.94780 ? 265 CYS B SG  1 
ATOM   4286 N N   . ALA B 1 264 ? 6.42452   -26.48482 -18.75578 1.000 27.87448 ? 266 ALA B N   1 
ATOM   4287 C CA  . ALA B 1 264 ? 7.13547   -27.03310 -19.91243 1.000 25.61987 ? 266 ALA B CA  1 
ATOM   4288 C C   . ALA B 1 264 ? 7.19334   -26.01531 -21.03977 1.000 25.82604 ? 266 ALA B C   1 
ATOM   4289 O O   . ALA B 1 264 ? 8.24689   -25.80067 -21.65308 1.000 27.12387 ? 266 ALA B O   1 
ATOM   4290 C CB  . ALA B 1 264 ? 6.45757   -28.31871 -20.38851 1.000 27.64039 ? 266 ALA B CB  1 
ATOM   4291 N N   . SER B 1 265 ? 6.06700   -25.35714 -21.29813 1.000 27.39436 ? 267 SER B N   1 
ATOM   4292 C CA  . SER B 1 265 ? 6.02332   -24.26259 -22.25778 1.000 26.12367 ? 267 SER B CA  1 
ATOM   4293 C C   . SER B 1 265 ? 6.98492   -23.14132 -21.86229 1.000 21.58052 ? 267 SER B C   1 
ATOM   4294 O O   . SER B 1 265 ? 7.84871   -22.74435 -22.65299 1.000 20.85204 ? 267 SER B O   1 
ATOM   4295 C CB  . SER B 1 265 ? 4.57335   -23.77222 -22.36263 1.000 22.02752 ? 267 SER B CB  1 
ATOM   4296 O OG  . SER B 1 265 ? 4.47981   -22.55942 -23.06898 1.000 31.77457 ? 267 SER B OG  1 
ATOM   4297 N N   . LEU B 1 266 ? 6.86809   -22.63609 -20.62399 1.000 19.55297 ? 268 LEU B N   1 
ATOM   4298 C CA  . LEU B 1 266 ? 7.77573   -21.58950 -20.14926 1.000 18.16305 ? 268 LEU B CA  1 
ATOM   4299 C C   . LEU B 1 266 ? 9.24492   -22.02180 -20.19456 1.000 19.57812 ? 268 LEU B C   1 
ATOM   4300 O O   . LEU B 1 266 ? 10.12009  -21.19355 -20.46535 1.000 18.76914 ? 268 LEU B O   1 
ATOM   4301 C CB  . LEU B 1 266 ? 7.38983   -21.15995 -18.72913 1.000 17.49545 ? 268 LEU B CB  1 
ATOM   4302 C CG  . LEU B 1 266 ? 8.35577   -20.27507 -17.92488 1.000 15.61838 ? 268 LEU B CG  1 
ATOM   4303 C CD1 . LEU B 1 266 ? 8.66247   -18.97864 -18.65259 1.000 13.88147 ? 268 LEU B CD1 1 
ATOM   4304 C CD2 . LEU B 1 266 ? 7.79190   -19.98180 -16.52884 1.000 10.52315 ? 268 LEU B CD2 1 
ATOM   4305 N N   . LYS B 1 267 ? 9.54370   -23.29890 -19.93393 1.000 21.06657 ? 269 LYS B N   1 
ATOM   4306 C CA  . LYS B 1 267 ? 10.90783  -23.79247 -20.14128 1.000 27.35488 ? 269 LYS B CA  1 
ATOM   4307 C C   . LYS B 1 267 ? 11.38896  -23.51806 -21.56116 1.000 28.21478 ? 269 LYS B C   1 
ATOM   4308 O O   . LYS B 1 267 ? 12.44077  -22.89831 -21.76750 1.000 33.29295 ? 269 LYS B O   1 
ATOM   4309 C CB  . LYS B 1 267 ? 10.98612  -25.29299 -19.86148 1.000 31.69678 ? 269 LYS B CB  1 
ATOM   4310 C CG  . LYS B 1 267 ? 10.90698  -25.67496 -18.40926 1.000 36.11058 ? 269 LYS B CG  1 
ATOM   4311 C CD  . LYS B 1 267 ? 10.78205  -27.18006 -18.25780 1.000 34.71563 ? 269 LYS B CD  1 
ATOM   4312 C CE  . LYS B 1 267 ? 12.13131  -27.85490 -18.09270 1.000 32.18581 ? 269 LYS B CE  1 
ATOM   4313 N NZ  . LYS B 1 267 ? 12.05218  -29.34063 -18.25373 1.000 26.72082 ? 269 LYS B NZ  1 
ATOM   4314 N N   . GLU B 1 268 ? 10.63377  -23.99736 -22.55485 1.000 34.83021 ? 270 GLU B N   1 
ATOM   4315 C CA  . GLU B 1 268 ? 11.03593  -23.83671 -23.94899 1.000 33.26336 ? 270 GLU B CA  1 
ATOM   4316 C C   . GLU B 1 268 ? 11.35782  -22.38425 -24.25862 1.000 27.45744 ? 270 GLU B C   1 
ATOM   4317 O O   . GLU B 1 268 ? 12.38545  -22.08562 -24.87625 1.000 36.70052 ? 270 GLU B O   1 
ATOM   4318 C CB  . GLU B 1 268 ? 9.93835   -24.35989 -24.88013 1.000 31.79238 ? 270 GLU B CB  1 
ATOM   4319 C CG  . GLU B 1 268 ? 9.50976   -25.80881 -24.60351 1.000 35.54868 ? 270 GLU B CG  1 
ATOM   4320 C CD  . GLU B 1 268 ? 10.66983  -26.80137 -24.66709 1.000 43.38448 ? 270 GLU B CD  1 
ATOM   4321 O OE1 . GLU B 1 268 ? 10.86190  -27.56677 -23.69132 1.000 46.97354 ? 270 GLU B OE1 1 
ATOM   4322 O OE2 . GLU B 1 268 ? 11.38719  -26.81828 -25.69286 1.000 38.41769 ? 270 GLU B OE2 1 
ATOM   4323 N N   . LEU B 1 269 ? 10.51555  -21.46708 -23.80291 1.000 25.87221 ? 271 LEU B N   1 
ATOM   4324 C CA  . LEU B 1 269 ? 10.78967  -20.04911 -23.95959 1.000 23.44918 ? 271 LEU B CA  1 
ATOM   4325 C C   . LEU B 1 269 ? 11.98351  -19.64072 -23.10166 1.000 23.20692 ? 271 LEU B C   1 
ATOM   4326 O O   . LEU B 1 269 ? 12.56666  -18.57667 -23.31830 1.000 21.32917 ? 271 LEU B O   1 
ATOM   4327 C CB  . LEU B 1 269 ? 9.55537   -19.22012 -23.59037 1.000 22.70578 ? 271 LEU B CB  1 
ATOM   4328 C CG  . LEU B 1 269 ? 8.18500   -19.77291 -23.99729 1.000 23.78979 ? 271 LEU B CG  1 
ATOM   4329 C CD1 . LEU B 1 269 ? 7.09642   -18.81983 -23.55017 1.000 23.74090 ? 271 LEU B CD1 1 
ATOM   4330 C CD2 . LEU B 1 269 ? 8.08378   -20.01651 -25.50070 1.000 23.30990 ? 271 LEU B CD2 1 
ATOM   4331 N N   . THR B 1 278 ? 6.07400   -12.75878 -30.24601 1.000 27.09331 ? 280 THR B N   1 
ATOM   4332 C CA  . THR B 1 278 ? 5.24181   -11.92923 -29.35860 1.000 29.31242 ? 280 THR B CA  1 
ATOM   4333 C C   . THR B 1 278 ? 4.08936   -12.73204 -28.71189 1.000 30.25820 ? 280 THR B C   1 
ATOM   4334 O O   . THR B 1 278 ? 3.59693   -13.69234 -29.31215 1.000 29.74515 ? 280 THR B O   1 
ATOM   4335 C CB  . THR B 1 278 ? 4.68098   -10.70892 -30.12999 1.000 25.59864 ? 280 THR B CB  1 
ATOM   4336 O OG1 . THR B 1 278 ? 4.29926   -9.67830  -29.21001 1.000 33.71147 ? 280 THR B OG1 1 
ATOM   4337 C CG2 . THR B 1 278 ? 3.48999   -11.09599 -30.96297 1.000 18.67714 ? 280 THR B CG2 1 
ATOM   4338 N N   . ILE B 1 279 ? 3.66319   -12.36204 -27.49155 1.000 27.79505 ? 281 ILE B N   1 
ATOM   4339 C CA  . ILE B 1 279 ? 2.72677   -13.17005 -26.71405 1.000 25.37219 ? 281 ILE B CA  1 
ATOM   4340 C C   . ILE B 1 279 ? 1.49052   -12.38847 -26.28610 1.000 31.26524 ? 281 ILE B C   1 
ATOM   4341 O O   . ILE B 1 279 ? 0.38578   -12.94307 -26.25361 1.000 38.43474 ? 281 ILE B O   1 
ATOM   4342 C CB  . ILE B 1 279 ? 3.40690   -13.81690 -25.48835 1.000 23.60508 ? 281 ILE B CB  1 
ATOM   4343 C CG1 . ILE B 1 279 ? 4.27762   -14.98515 -25.93959 1.000 22.64477 ? 281 ILE B CG1 1 
ATOM   4344 C CG2 . ILE B 1 279 ? 2.36628   -14.32484 -24.50021 1.000 19.69630 ? 281 ILE B CG2 1 
ATOM   4345 C CD1 . ILE B 1 279 ? 4.63599   -15.93909 -24.83893 1.000 22.77937 ? 281 ILE B CD1 1 
ATOM   4346 N N   . LEU B 1 280 ? 1.63271   -11.11812 -25.93581 1.000 26.52775 ? 282 LEU B N   1 
ATOM   4347 C CA  . LEU B 1 280 ? 0.44622   -10.27393 -25.77997 1.000 22.21075 ? 282 LEU B CA  1 
ATOM   4348 C C   . LEU B 1 280 ? 0.81410   -8.85752  -26.20128 1.000 19.05101 ? 282 LEU B C   1 
ATOM   4349 O O   . LEU B 1 280 ? 0.65294   -7.89369  -25.45097 1.000 20.49721 ? 282 LEU B O   1 
ATOM   4350 C CB  . LEU B 1 280 ? -0.09856  -10.31661 -24.34947 1.000 19.24557 ? 282 LEU B CB  1 
ATOM   4351 C CG  . LEU B 1 280 ? -1.22569  -11.28456 -23.98551 1.000 24.61458 ? 282 LEU B CG  1 
ATOM   4352 C CD1 . LEU B 1 280 ? -1.29617  -11.46509 -22.47168 1.000 21.58207 ? 282 LEU B CD1 1 
ATOM   4353 C CD2 . LEU B 1 280 ? -2.58406  -10.82806 -24.54631 1.000 17.72521 ? 282 LEU B CD2 1 
ATOM   4354 N N   . GLY B 1 281 ? 1.33663   -8.72573  -27.41520 1.000 15.46008 ? 283 GLY B N   1 
ATOM   4355 C CA  . GLY B 1 281 ? 1.95618   -7.47434  -27.79065 1.000 27.10167 ? 283 GLY B CA  1 
ATOM   4356 C C   . GLY B 1 281 ? 3.26657   -7.21647  -27.08660 1.000 22.93804 ? 283 GLY B C   1 
ATOM   4357 O O   . GLY B 1 281 ? 3.69551   -6.06365  -26.98355 1.000 25.30130 ? 283 GLY B O   1 
ATOM   4358 N N   . SER B 1 282 ? 3.90878   -8.26302  -26.58150 1.000 23.96969 ? 284 SER B N   1 
ATOM   4359 C CA  . SER B 1 282 ? 5.18085   -8.13297  -25.89316 1.000 20.30829 ? 284 SER B CA  1 
ATOM   4360 C C   . SER B 1 282 ? 6.14562   -9.17839  -26.42613 1.000 20.39137 ? 284 SER B C   1 
ATOM   4361 O O   . SER B 1 282 ? 5.74525   -10.31487 -26.69650 1.000 20.12435 ? 284 SER B O   1 
ATOM   4362 C CB  . SER B 1 282 ? 5.00310   -8.30842  -24.38166 1.000 19.15415 ? 284 SER B CB  1 
ATOM   4363 O OG  . SER B 1 282 ? 6.14226   -7.84683  -23.67853 1.000 22.63807 ? 284 SER B OG  1 
ATOM   4364 N N   . ALA B 1 283 ? 7.41345   -8.78720  -26.57765 1.000 17.72329 ? 285 ALA B N   1 
ATOM   4365 C CA  . ALA B 1 283 ? 8.50102   -9.71381  -26.87116 1.000 19.61546 ? 285 ALA B CA  1 
ATOM   4366 C C   . ALA B 1 283 ? 9.32521   -10.05189 -25.63528 1.000 18.66945 ? 285 ALA B C   1 
ATOM   4367 O O   . ALA B 1 283 ? 10.36754  -10.69298 -25.75997 1.000 23.41697 ? 285 ALA B O   1 
ATOM   4368 C CB  . ALA B 1 283 ? 9.41217   -9.15123  -27.96646 1.000 20.83710 ? 285 ALA B CB  1 
ATOM   4369 N N   . LEU B 1 284 ? 8.87011   -9.63431  -24.45548 1.000 18.46845 ? 286 LEU B N   1 
ATOM   4370 C CA  . LEU B 1 284 ? 9.40375   -9.99709  -23.14896 1.000 17.64923 ? 286 LEU B CA  1 
ATOM   4371 C C   . LEU B 1 284 ? 8.38432   -10.83017 -22.37888 1.000 18.07023 ? 286 LEU B C   1 
ATOM   4372 O O   . LEU B 1 284 ? 7.17760   -10.63305 -22.51676 1.000 15.46919 ? 286 LEU B O   1 
ATOM   4373 C CB  . LEU B 1 284 ? 9.70591   -8.73875  -22.33308 1.000 20.25308 ? 286 LEU B CB  1 
ATOM   4374 C CG  . LEU B 1 284 ? 11.11101  -8.19512  -22.25780 1.000 21.93043 ? 286 LEU B CG  1 
ATOM   4375 C CD1 . LEU B 1 284 ? 11.73473  -8.25683  -23.62817 1.000 26.75534 ? 286 LEU B CD1 1 
ATOM   4376 C CD2 . LEU B 1 284 ? 11.04678  -6.75833  -21.73213 1.000 22.51949 ? 286 LEU B CD2 1 
ATOM   4377 N N   . LEU B 1 285 ? 8.86198   -11.74472 -21.54406 1.000 13.47203 ? 287 LEU B N   1 
ATOM   4378 C CA  . LEU B 1 285 ? 7.95856   -12.40524 -20.60659 1.000 12.80576 ? 287 LEU B CA  1 
ATOM   4379 C C   . LEU B 1 285 ? 7.60155   -11.41567 -19.50014 1.000 11.39073 ? 287 LEU B C   1 
ATOM   4380 O O   . LEU B 1 285 ? 8.45764   -11.03669 -18.69621 1.000 16.81556 ? 287 LEU B O   1 
ATOM   4381 C CB  . LEU B 1 285 ? 8.59939   -13.67534 -20.05164 1.000 7.17374  ? 287 LEU B CB  1 
ATOM   4382 C CG  . LEU B 1 285 ? 8.84802   -14.73147 -21.14251 1.000 13.51585 ? 287 LEU B CG  1 
ATOM   4383 C CD1 . LEU B 1 285 ? 9.42940   -16.02482 -20.59626 1.000 16.56312 ? 287 LEU B CD1 1 
ATOM   4384 C CD2 . LEU B 1 285 ? 7.57189   -15.02496 -21.92192 1.000 13.85703 ? 287 LEU B CD2 1 
ATOM   4385 N N   . GLU B 1 286 ? 6.34739   -10.97374 -19.47012 1.000 13.05770 ? 288 GLU B N   1 
ATOM   4386 C CA  . GLU B 1 286 ? 5.91963   -9.95587  -18.51650 1.000 15.42658 ? 288 GLU B CA  1 
ATOM   4387 C C   . GLU B 1 286 ? 5.69287   -10.56331 -17.13780 1.000 12.07665 ? 288 GLU B C   1 
ATOM   4388 O O   . GLU B 1 286 ? 5.05248   -11.61005 -17.01117 1.000 12.10389 ? 288 GLU B O   1 
ATOM   4389 C CB  . GLU B 1 286 ? 4.63363   -9.28174  -19.00293 1.000 15.89179 ? 288 GLU B CB  1 
ATOM   4390 C CG  . GLU B 1 286 ? 4.78877   -8.47754  -20.29525 1.000 23.27079 ? 288 GLU B CG  1 
ATOM   4391 C CD  . GLU B 1 286 ? 5.33175   -7.07892  -20.05328 1.000 33.05489 ? 288 GLU B CD  1 
ATOM   4392 O OE1 . GLU B 1 286 ? 4.68964   -6.31106  -19.30265 1.000 43.90023 ? 288 GLU B OE1 1 
ATOM   4393 O OE2 . GLU B 1 286 ? 6.38943   -6.74114  -20.62146 1.000 34.79533 ? 288 GLU B OE2 1 
ATOM   4394 N N   . ASP B 1 287 ? 6.18342   -9.88707  -16.08762 1.000 10.57682 ? 289 ASP B N   1 
ATOM   4395 C CA  . ASP B 1 287 ? 6.04616   -10.46220 -14.74662 1.000 9.08482  ? 289 ASP B CA  1 
ATOM   4396 C C   . ASP B 1 287 ? 5.51492   -9.47213  -13.70407 1.000 11.42645 ? 289 ASP B C   1 
ATOM   4397 O O   . ASP B 1 287 ? 5.83385   -9.58628  -12.51490 1.000 9.26726  ? 289 ASP B O   1 
ATOM   4398 C CB  . ASP B 1 287 ? 7.36962   -11.07874 -14.27740 1.000 9.67789  ? 289 ASP B CB  1 
ATOM   4399 C CG  . ASP B 1 287 ? 8.40010   -10.04752 -13.83612 1.000 11.00646 ? 289 ASP B CG  1 
ATOM   4400 O OD1 . ASP B 1 287 ? 8.30745   -8.86319  -14.22303 1.000 8.20738  ? 289 ASP B OD1 1 
ATOM   4401 O OD2 . ASP B 1 287 ? 9.33027   -10.45288 -13.09532 1.000 15.28559 ? 289 ASP B OD2 1 
ATOM   4402 N N   . GLU B 1 288 ? 4.67799   -8.51389  -14.09849 1.000 10.65526 ? 290 GLU B N   1 
ATOM   4403 C CA  . GLU B 1 288 ? 4.05476   -7.64429  -13.10729 1.000 10.19572 ? 290 GLU B CA  1 
ATOM   4404 C C   . GLU B 1 288 ? 2.52863   -7.70988  -13.17523 1.000 8.69105  ? 290 GLU B C   1 
ATOM   4405 O O   . GLU B 1 288 ? 1.85519   -6.72349  -12.88635 1.000 11.72834 ? 290 GLU B O   1 
ATOM   4406 C CB  . GLU B 1 288 ? 4.56063   -6.20387  -13.23672 1.000 11.57277 ? 290 GLU B CB  1 
ATOM   4407 C CG  . GLU B 1 288 ? 6.09249   -6.08717  -13.14774 1.000 13.14852 ? 290 GLU B CG  1 
ATOM   4408 C CD  . GLU B 1 288 ? 6.59823   -4.79925  -12.48393 1.000 13.27362 ? 290 GLU B CD  1 
ATOM   4409 O OE1 . GLU B 1 288 ? 7.70246   -4.82014  -11.88033 1.000 12.98489 ? 290 GLU B OE1 1 
ATOM   4410 O OE2 . GLU B 1 288 ? 5.91093   -3.76015  -12.56680 1.000 13.89702 ? 290 GLU B OE2 1 
ATOM   4411 N N   . PHE B 1 289 ? 1.97600   -8.86998  -13.55550 1.000 8.07117  ? 291 PHE B N   1 
ATOM   4412 C CA  . PHE B 1 289 ? 0.56145   -9.20666  -13.36235 1.000 8.93448  ? 291 PHE B CA  1 
ATOM   4413 C C   . PHE B 1 289 ? 0.48972   -10.40935 -12.43193 1.000 9.79130  ? 291 PHE B C   1 
ATOM   4414 O O   . PHE B 1 289 ? 1.05200   -11.46354 -12.74401 1.000 11.05639 ? 291 PHE B O   1 
ATOM   4415 C CB  . PHE B 1 289 ? -0.14801  -9.57061  -14.67294 1.000 8.90337  ? 291 PHE B CB  1 
ATOM   4416 C CG  . PHE B 1 289 ? -0.17537  -8.47853  -15.70544 1.000 11.51877 ? 291 PHE B CG  1 
ATOM   4417 C CD1 . PHE B 1 289 ? -1.15623  -7.49973  -15.67830 1.000 15.31524 ? 291 PHE B CD1 1 
ATOM   4418 C CD2 . PHE B 1 289 ? 0.74914   -8.46438  -16.74112 1.000 17.84206 ? 291 PHE B CD2 1 
ATOM   4419 C CE1 . PHE B 1 289 ? -1.20288  -6.50691  -16.66117 1.000 21.12550 ? 291 PHE B CE1 1 
ATOM   4420 C CE2 . PHE B 1 289 ? 0.71598   -7.47633  -17.72173 1.000 18.32099 ? 291 PHE B CE2 1 
ATOM   4421 C CZ  . PHE B 1 289 ? -0.26255  -6.49825  -17.68056 1.000 18.41982 ? 291 PHE B CZ  1 
ATOM   4422 N N   . THR B 1 290 ? -0.19511  -10.26353 -11.30164 1.000 10.52028 ? 292 THR B N   1 
ATOM   4423 C CA  . THR B 1 290 ? -0.41581  -11.38929 -10.40077 1.000 8.53313  ? 292 THR B CA  1 
ATOM   4424 C C   . THR B 1 290 ? -1.52553  -12.28238 -10.93640 1.000 11.80516 ? 292 THR B C   1 
ATOM   4425 O O   . THR B 1 290 ? -2.26054  -11.90795 -11.85374 1.000 10.25629 ? 292 THR B O   1 
ATOM   4426 C CB  . THR B 1 290 ? -0.79339  -10.89302 -9.00619  1.000 11.21392 ? 292 THR B CB  1 
ATOM   4427 O OG1 . THR B 1 290 ? -2.09357  -10.29795 -9.06168  1.000 12.75057 ? 292 THR B OG1 1 
ATOM   4428 C CG2 . THR B 1 290 ? 0.21175   -9.88524  -8.48630  1.000 6.93272  ? 292 THR B CG2 1 
ATOM   4429 N N   . PRO B 1 291 ? -1.66873  -13.48853 -10.37923 1.000 14.83873 ? 293 PRO B N   1 
ATOM   4430 C CA  . PRO B 1 291 ? -2.86658  -14.28584 -10.67614 1.000 11.48284 ? 293 PRO B CA  1 
ATOM   4431 C C   . PRO B 1 291 ? -4.16712  -13.52589 -10.45523 1.000 18.80228 ? 293 PRO B C   1 
ATOM   4432 O O   . PRO B 1 291 ? -5.06801  -13.58853 -11.30071 1.000 11.89635 ? 293 PRO B O   1 
ATOM   4433 C CB  . PRO B 1 291 ? -2.72267  -15.46807 -9.71613  1.000 11.09125 ? 293 PRO B CB  1 
ATOM   4434 C CG  . PRO B 1 291 ? -1.22913  -15.66983 -9.62225  1.000 14.21683 ? 293 PRO B CG  1 
ATOM   4435 C CD  . PRO B 1 291 ? -0.64767  -14.27395 -9.65135  1.000 11.99422 ? 293 PRO B CD  1 
ATOM   4436 N N   . PHE B 1 292 ? -4.27845  -12.79405 -9.34207  1.000 18.89663 ? 294 PHE B N   1 
ATOM   4437 C CA  . PHE B 1 292 ? -5.49826  -12.04230 -9.05947  1.000 21.16612 ? 294 PHE B CA  1 
ATOM   4438 C C   . PHE B 1 292 ? -5.71404  -10.93858 -10.08480 1.000 21.75057 ? 294 PHE B C   1 
ATOM   4439 O O   . PHE B 1 292 ? -6.83713  -10.73656 -10.55525 1.000 17.49345 ? 294 PHE B O   1 
ATOM   4440 C CB  . PHE B 1 292 ? -5.43665  -11.47260 -7.64256  1.000 21.51658 ? 294 PHE B CB  1 
ATOM   4441 C CG  . PHE B 1 292 ? -6.44775  -10.39161 -7.37142  1.000 37.45936 ? 294 PHE B CG  1 
ATOM   4442 C CD1 . PHE B 1 292 ? -7.79967  -10.69100 -7.25936  1.000 40.36956 ? 294 PHE B CD1 1 
ATOM   4443 C CD2 . PHE B 1 292 ? -6.04419  -9.07152  -7.21129  1.000 41.02775 ? 294 PHE B CD2 1 
ATOM   4444 C CE1 . PHE B 1 292 ? -8.73108  -9.69112  -7.00283  1.000 35.82423 ? 294 PHE B CE1 1 
ATOM   4445 C CE2 . PHE B 1 292 ? -6.97486  -8.06832  -6.95247  1.000 42.04963 ? 294 PHE B CE2 1 
ATOM   4446 C CZ  . PHE B 1 292 ? -8.31505  -8.38162  -6.84655  1.000 32.61153 ? 294 PHE B CZ  1 
ATOM   4447 N N   . ASP B 1 293 ? -4.64524  -10.22093 -10.44756 1.000 17.79489 ? 295 ASP B N   1 
ATOM   4448 C CA  . ASP B 1 293 ? -4.72719  -9.23446  -11.51914 1.000 13.85468 ? 295 ASP B CA  1 
ATOM   4449 C C   . ASP B 1 293 ? -5.33955  -9.83918  -12.77843 1.000 16.79222 ? 295 ASP B C   1 
ATOM   4450 O O   . ASP B 1 293 ? -6.23616  -9.25120  -13.39184 1.000 16.40130 ? 295 ASP B O   1 
ATOM   4451 C CB  . ASP B 1 293 ? -3.33377  -8.67286  -11.82803 1.000 17.78205 ? 295 ASP B CB  1 
ATOM   4452 C CG  . ASP B 1 293 ? -2.74636  -7.86075  -10.67600 1.000 13.74012 ? 295 ASP B CG  1 
ATOM   4453 O OD1 . ASP B 1 293 ? -3.46498  -7.59225  -9.69093  1.000 17.59662 ? 295 ASP B OD1 1 
ATOM   4454 O OD2 . ASP B 1 293 ? -1.56312  -7.48596  -10.76648 1.000 11.84779 ? 295 ASP B OD2 1 
ATOM   4455 N N   . VAL B 1 294 ? -4.87082  -11.02500 -13.17255 1.000 16.35798 ? 296 VAL B N   1 
ATOM   4456 C CA  . VAL B 1 294 ? -5.33774  -11.62976 -14.41806 1.000 17.62188 ? 296 VAL B CA  1 
ATOM   4457 C C   . VAL B 1 294 ? -6.82151  -11.97546 -14.32128 1.000 25.64188 ? 296 VAL B C   1 
ATOM   4458 O O   . VAL B 1 294 ? -7.57238  -11.81699 -15.29320 1.000 21.97257 ? 296 VAL B O   1 
ATOM   4459 C CB  . VAL B 1 294 ? -4.49269  -12.86871 -14.78255 1.000 12.33641 ? 296 VAL B CB  1 
ATOM   4460 C CG1 . VAL B 1 294 ? -5.17678  -13.66978 -15.88270 1.000 16.77876 ? 296 VAL B CG1 1 
ATOM   4461 C CG2 . VAL B 1 294 ? -3.07197  -12.47642 -15.22806 1.000 10.91657 ? 296 VAL B CG2 1 
ATOM   4462 N N   . VAL B 1 295 ? -7.27134  -12.44217 -13.15195 1.000 23.48362 ? 297 VAL B N   1 
ATOM   4463 C CA  . VAL B 1 295 ? -8.66430  -12.85883 -13.00816 1.000 20.73172 ? 297 VAL B CA  1 
ATOM   4464 C C   . VAL B 1 295 ? -9.59263  -11.64850 -13.03686 1.000 26.43726 ? 297 VAL B C   1 
ATOM   4465 O O   . VAL B 1 295 ? -10.61277 -11.64920 -13.73503 1.000 29.25257 ? 297 VAL B O   1 
ATOM   4466 C CB  . VAL B 1 295 ? -8.84757  -13.69285 -11.73013 1.000 27.68493 ? 297 VAL B CB  1 
ATOM   4467 C CG1 . VAL B 1 295 ? -10.33134 -13.73592 -11.32009 1.000 24.34974 ? 297 VAL B CG1 1 
ATOM   4468 C CG2 . VAL B 1 295 ? -8.30973  -15.09509 -11.95493 1.000 16.55246 ? 297 VAL B CG2 1 
ATOM   4469 N N   . ARG B 1 296 ? -9.25788  -10.59825 -12.28752 1.000 24.81185 ? 298 ARG B N   1 
ATOM   4470 C CA  . ARG B 1 296 ? -9.85972  -9.30380  -12.56145 1.000 25.83935 ? 298 ARG B CA  1 
ATOM   4471 C C   . ARG B 1 296 ? -9.50591  -8.89683  -13.99443 1.000 31.79679 ? 298 ARG B C   1 
ATOM   4472 O O   . ARG B 1 296 ? -8.73473  -9.56598  -14.67968 1.000 40.15330 ? 298 ARG B O   1 
ATOM   4473 C CB  . ARG B 1 296 ? -9.38027  -8.26792  -11.54613 1.000 23.29759 ? 298 ARG B CB  1 
ATOM   4474 N N   . GLN B 1 297 ? -10.10591 -7.81230  -14.47595 1.000 41.34426 ? 299 GLN B N   1 
ATOM   4475 C CA  . GLN B 1 297 ? -9.86552  -7.37809  -15.85559 1.000 39.57898 ? 299 GLN B CA  1 
ATOM   4476 C C   . GLN B 1 297 ? -10.35826 -8.40060  -16.88215 1.000 38.62548 ? 299 GLN B C   1 
ATOM   4477 O O   . GLN B 1 297 ? -10.95073 -8.01388  -17.89506 1.000 39.72958 ? 299 GLN B O   1 
ATOM   4478 C CB  . GLN B 1 297 ? -8.37191  -7.05959  -16.09440 1.000 29.45270 ? 299 GLN B CB  1 
ATOM   4479 C CG  . GLN B 1 297 ? -8.02428  -6.79933  -17.55923 1.000 24.48096 ? 299 GLN B CG  1 
ATOM   4480 C CD  . GLN B 1 297 ? -6.63373  -6.21007  -17.77412 1.000 26.10504 ? 299 GLN B CD  1 
ATOM   4481 O OE1 . GLN B 1 297 ? -6.33670  -5.68902  -18.85145 1.000 22.95720 ? 299 GLN B OE1 1 
ATOM   4482 N NE2 . GLN B 1 297 ? -5.77713  -6.29608  -16.75982 1.000 22.33493 ? 299 GLN B NE2 1 
ATOM   4483 N N   . CYS B 1 298 ? -10.11027 -9.69325  -16.65379 1.000 31.49871 ? 300 CYS B N   1 
ATOM   4484 C CA  . CYS B 1 298 ? -10.63724 -10.75252 -17.53127 1.000 34.60354 ? 300 CYS B CA  1 
ATOM   4485 C C   . CYS B 1 298 ? -12.12289 -11.05053 -17.24325 1.000 31.20666 ? 300 CYS B C   1 
ATOM   4486 O O   . CYS B 1 298 ? -12.55482 -11.14090 -16.08254 1.000 30.39727 ? 300 CYS B O   1 
ATOM   4487 C CB  . CYS B 1 298 ? -9.81710  -12.03669 -17.38710 1.000 23.36598 ? 300 CYS B CB  1 
ATOM   4488 S SG  . CYS B 1 298 ? -8.25444  -12.09112 -18.32228 1.000 36.54740 ? 300 CYS B SG  1 
HETATM 4489 C C02 . X77 C 2 .   ? -21.82354 -4.93738  -25.12402 1.000 7.26255  ? 401 X77 A C02 1 
HETATM 4490 C C04 . X77 C 2 .   ? -20.18678 -5.84712  -26.89601 1.000 8.95941  ? 401 X77 A C04 1 
HETATM 4491 C C05 . X77 C 2 .   ? -19.98946 -5.76398  -28.40928 1.000 7.17040  ? 401 X77 A C05 1 
HETATM 4492 C C07 . X77 C 2 .   ? -20.16177 -6.87096  -30.68843 1.000 12.80141 ? 401 X77 A C07 1 
HETATM 4493 C C08 . X77 C 2 .   ? -20.11684 -8.31283  -31.19500 1.000 12.60572 ? 401 X77 A C08 1 
HETATM 4494 C C09 . X77 C 2 .   ? -20.15941 -8.42269  -32.72030 1.000 7.84672  ? 401 X77 A C09 1 
HETATM 4495 C C10 . X77 C 2 .   ? -21.22227 -7.54023  -33.37731 1.000 14.55574 ? 401 X77 A C10 1 
HETATM 4496 C C11 . X77 C 2 .   ? -21.30352 -6.11436  -32.81769 1.000 15.03692 ? 401 X77 A C11 1 
HETATM 4497 C C12 . X77 C 2 .   ? -21.29878 -6.05166  -31.28865 1.000 9.51198  ? 401 X77 A C12 1 
HETATM 4498 C C14 . X77 C 2 .   ? -18.85387 -5.37439  -26.30351 1.000 5.54316  ? 401 X77 A C14 1 
HETATM 4499 C C15 . X77 C 2 .   ? -17.89045 -6.40677  -25.84351 1.000 8.72062  ? 401 X77 A C15 1 
HETATM 4500 C C16 . X77 C 2 .   ? -16.54120 -6.00504  -25.30042 1.000 6.52575  ? 401 X77 A C16 1 
HETATM 4501 C C17 . X77 C 2 .   ? -16.19475 -4.52046  -25.21795 1.000 7.06611  ? 401 X77 A C17 1 
HETATM 4502 C C19 . X77 C 2 .   ? -18.49331 -3.89559  -26.24150 1.000 5.47082  ? 401 X77 A C19 1 
HETATM 4503 C C20 . X77 C 2 .   ? -22.17581 -4.48764  -27.58863 1.000 6.89349  ? 401 X77 A C20 1 
HETATM 4504 C C21 . X77 C 2 .   ? -23.24102 -5.44221  -28.11595 1.000 8.42436  ? 401 X77 A C21 1 
HETATM 4505 C C22 . X77 C 2 .   ? -24.18798 -4.97430  -29.21312 1.000 9.21370  ? 401 X77 A C22 1 
HETATM 4506 C C23 . X77 C 2 .   ? -24.04405 -3.55210  -29.76673 1.000 8.08415  ? 401 X77 A C23 1 
HETATM 4507 C C24 . X77 C 2 .   ? -25.04029 -3.14663  -30.86812 1.000 14.03233 ? 401 X77 A C24 1 
HETATM 4508 C C25 . X77 C 2 .   ? -26.40329 -2.99855  -30.19629 1.000 11.68204 ? 401 X77 A C25 1 
HETATM 4509 C C26 . X77 C 2 .   ? -25.10176 -4.24686  -31.90890 1.000 14.01744 ? 401 X77 A C26 1 
HETATM 4510 C C27 . X77 C 2 .   ? -24.61961 -1.80514  -31.51784 1.000 10.67861 ? 401 X77 A C27 1 
HETATM 4511 C C28 . X77 C 2 .   ? -22.98014 -2.59357  -29.24020 1.000 4.80480  ? 401 X77 A C28 1 
HETATM 4512 C C29 . X77 C 2 .   ? -22.02616 -3.05450  -28.11748 1.000 5.35027  ? 401 X77 A C29 1 
HETATM 4513 C C30 . X77 C 2 .   ? -23.07625 -4.14658  -24.68015 1.000 8.22331  ? 401 X77 A C30 1 
HETATM 4514 C C31 . X77 C 2 .   ? -24.05234 -3.57698  -25.47018 1.000 4.70580  ? 401 X77 A C31 1 
HETATM 4515 C C33 . X77 C 2 .   ? -24.52553 -3.17905  -23.39716 1.000 11.41105 ? 401 X77 A C33 1 
HETATM 4516 N N03 . X77 C 2 .   ? -21.36249 -5.06236  -26.52227 1.000 5.83432  ? 401 X77 A N03 1 
HETATM 4517 N N06 . X77 C 2 .   ? -20.34704 -6.92014  -29.23207 1.000 7.98566  ? 401 X77 A N06 1 
HETATM 4518 N N18 . X77 C 2 .   ? -17.16261 -3.48630  -25.69977 1.000 6.78054  ? 401 X77 A N18 1 
HETATM 4519 N N32 . X77 C 2 .   ? -24.92005 -2.99372  -24.67710 1.000 6.98410  ? 401 X77 A N32 1 
HETATM 4520 N N34 . X77 C 2 .   ? -23.37758 -3.89000  -23.42087 1.000 10.88677 ? 401 X77 A N34 1 
HETATM 4521 O O01 . X77 C 2 .   ? -21.17827 -5.45070  -24.30078 1.000 11.83932 ? 401 X77 A O01 1 
HETATM 4522 O O13 . X77 C 2 .   ? -19.53536 -4.78979  -28.92040 1.000 7.61818  ? 401 X77 A O13 1 
HETATM 4523 C C02 . X77 D 2 .   ? 14.09678  13.93193  -3.89454  1.000 13.10499 ? 401 X77 B C02 1 
HETATM 4524 C C04 . X77 D 2 .   ? 15.72461  12.07343  -4.89739  1.000 13.73294 ? 401 X77 B C04 1 
HETATM 4525 C C05 . X77 D 2 .   ? 16.47039  10.82164  -4.40026  1.000 13.37407 ? 401 X77 B C05 1 
HETATM 4526 C C07 . X77 D 2 .   ? 19.14203  11.22807  -4.21942  1.000 23.82309 ? 401 X77 B C07 1 
HETATM 4527 C C08 . X77 D 2 .   ? 19.52341  11.23632  -2.74269  1.000 20.51877 ? 401 X77 B C08 1 
HETATM 4528 C C09 . X77 D 2 .   ? 20.00662  9.86835   -2.26533  1.000 22.22474 ? 401 X77 B C09 1 
HETATM 4529 C C10 . X77 D 2 .   ? 21.36144  9.57268   -2.91065  1.000 24.44773 ? 401 X77 B C10 1 
HETATM 4530 C C11 . X77 D 2 .   ? 21.37729  9.85313   -4.41873  1.000 21.85587 ? 401 X77 B C11 1 
HETATM 4531 C C12 . X77 D 2 .   ? 20.08043  10.36627  -5.06585  1.000 20.16995 ? 401 X77 B C12 1 
HETATM 4532 C C14 . X77 D 2 .   ? 14.65584  11.46116  -5.81171  1.000 14.86572 ? 401 X77 B C14 1 
HETATM 4533 C C15 . X77 D 2 .   ? 13.41013  10.83982  -5.25812  1.000 10.13663 ? 401 X77 B C15 1 
HETATM 4534 C C16 . X77 D 2 .   ? 12.41716  10.21929  -6.17766  1.000 10.96413 ? 401 X77 B C16 1 
HETATM 4535 C C17 . X77 D 2 .   ? 12.65757  10.20876  -7.68074  1.000 14.52550 ? 401 X77 B C17 1 
HETATM 4536 C C19 . X77 D 2 .   ? 14.88902  11.43916  -7.30912  1.000 15.05475 ? 401 X77 B C19 1 
HETATM 4537 C C20 . X77 D 2 .   ? 15.72191  12.58166  -2.45288  1.000 16.06748 ? 401 X77 B C20 1 
HETATM 4538 C C21 . X77 D 2 .   ? 16.93954  13.40765  -2.06222  1.000 11.99679 ? 401 X77 B C21 1 
HETATM 4539 C C22 . X77 D 2 .   ? 17.60666  13.19794  -0.70069  1.000 14.31802 ? 401 X77 B C22 1 
HETATM 4540 C C23 . X77 D 2 .   ? 17.03327  12.14731  0.25306   1.000 14.29863 ? 401 X77 B C23 1 
HETATM 4541 C C24 . X77 D 2 .   ? 17.74538  11.95586  1.59303   1.000 14.26346 ? 401 X77 B C24 1 
HETATM 4542 C C25 . X77 D 2 .   ? 19.25240  11.87079  1.29913   1.000 15.52599 ? 401 X77 B C25 1 
HETATM 4543 C C26 . X77 D 2 .   ? 17.23971  10.67705  2.22003   1.000 9.23714  ? 401 X77 B C26 1 
HETATM 4544 C C27 . X77 D 2 .   ? 17.42992  13.16106  2.51551   1.000 16.60578 ? 401 X77 B C27 1 
HETATM 4545 C C28 . X77 D 2 .   ? 15.81473  11.30725  -0.13222  1.000 11.52855 ? 401 X77 B C28 1 
HETATM 4546 C C29 . X77 D 2 .   ? 15.13255  11.52324  -1.50067  1.000 11.13032 ? 401 X77 B C29 1 
HETATM 4547 C C30 . X77 D 2 .   ? 13.58356  14.74175  -2.67108  1.000 16.07092 ? 401 X77 B C30 1 
HETATM 4548 C C31 . X77 D 2 .   ? 13.94814  14.63810  -1.34608  1.000 9.89253  ? 401 X77 B C31 1 
HETATM 4549 C C33 . X77 D 2 .   ? 12.48357  16.19627  -1.49876  1.000 15.23809 ? 401 X77 B C33 1 
HETATM 4550 N N03 . X77 D 2 .   ? 15.14344  12.85800  -3.77885  1.000 14.18460 ? 401 X77 B N03 1 
HETATM 4551 N N06 . X77 D 2 .   ? 17.88810  10.50662  -4.17495  1.000 20.38832 ? 401 X77 B N06 1 
HETATM 4552 N N18 . X77 D 2 .   ? 13.89146  10.82417  -8.22955  1.000 11.54040 ? 401 X77 B N18 1 
HETATM 4553 N N32 . X77 D 2 .   ? 13.27362  15.51760  -0.64894  1.000 7.78587  ? 401 X77 B N32 1 
HETATM 4554 N N34 . X77 D 2 .   ? 12.69430  15.70692  -2.74065  1.000 16.07530 ? 401 X77 B N34 1 
HETATM 4555 O O01 . X77 D 2 .   ? 13.62144  14.21697  -4.93716  1.000 15.44607 ? 401 X77 B O01 1 
HETATM 4556 O O13 . X77 D 2 .   ? 15.84591  9.85323   -4.17833  1.000 13.95569 ? 401 X77 B O13 1 
HETATM 4557 O O   . HOH E 3 .   ? -5.72888  7.27378   -40.45681 1.000 15.56142 ? 501 HOH A O   1 
HETATM 4558 O O   . HOH E 3 .   ? -17.48064 15.88703  -33.66364 1.000 20.52963 ? 502 HOH A O   1 
HETATM 4559 O O   . HOH E 3 .   ? 18.93565  9.75504   -47.43858 1.000 7.76377  ? 503 HOH A O   1 
HETATM 4560 O O   . HOH E 3 .   ? 12.51707  2.08614   -52.11459 1.000 8.26508  ? 504 HOH A O   1 
HETATM 4561 O O   . HOH E 3 .   ? -32.48959 19.59390  -15.58738 1.000 23.57704 ? 505 HOH A O   1 
HETATM 4562 O O   . HOH E 3 .   ? 6.30116   13.83896  -45.49571 1.000 26.48638 ? 506 HOH A O   1 
HETATM 4563 O O   . HOH E 3 .   ? -16.02642 14.54338  -10.57995 1.000 13.01989 ? 507 HOH A O   1 
HETATM 4564 O O   . HOH E 3 .   ? -18.91489 6.00385   -39.09732 1.000 14.77224 ? 508 HOH A O   1 
HETATM 4565 O O   . HOH E 3 .   ? 4.79894   -1.63825  -38.13685 1.000 17.26998 ? 509 HOH A O   1 
HETATM 4566 O O   . HOH E 3 .   ? -30.61389 -6.39054  -23.19394 1.000 25.17839 ? 510 HOH A O   1 
HETATM 4567 O O   . HOH E 3 .   ? -15.51241 -3.10802  -42.38749 1.000 22.96959 ? 511 HOH A O   1 
HETATM 4568 O O   . HOH E 3 .   ? -42.60621 3.86241   -24.43833 1.000 19.66312 ? 512 HOH A O   1 
HETATM 4569 O O   . HOH E 3 .   ? -0.80732  -1.64772  -35.02531 1.000 18.86714 ? 513 HOH A O   1 
HETATM 4570 O O   . HOH E 3 .   ? 17.85265  5.28834   -47.04940 1.000 6.69790  ? 514 HOH A O   1 
HETATM 4571 O O   . HOH E 3 .   ? 17.91713  -1.68618  -44.20961 1.000 9.05537  ? 515 HOH A O   1 
HETATM 4572 O O   . HOH E 3 .   ? 21.59451  -6.50385  -38.40403 1.000 11.40492 ? 516 HOH A O   1 
HETATM 4573 O O   . HOH E 3 .   ? -32.71651 -5.54648  -36.65641 1.000 17.11769 ? 517 HOH A O   1 
HETATM 4574 O O   . HOH E 3 .   ? 23.79680  10.75579  -36.78219 1.000 14.79209 ? 518 HOH A O   1 
HETATM 4575 O O   . HOH E 3 .   ? -29.94845 1.83434   -14.39925 1.000 8.88136  ? 519 HOH A O   1 
HETATM 4576 O O   . HOH E 3 .   ? 15.71214  -4.89282  -43.20630 1.000 9.87344  ? 520 HOH A O   1 
HETATM 4577 O O   . HOH E 3 .   ? -38.80011 10.31029  -39.95198 1.000 20.54200 ? 521 HOH A O   1 
HETATM 4578 O O   . HOH E 3 .   ? 20.45201  -3.46530  -32.44511 1.000 10.81648 ? 522 HOH A O   1 
HETATM 4579 O O   . HOH E 3 .   ? 19.30345  6.93574   -49.11311 1.000 9.05668  ? 523 HOH A O   1 
HETATM 4580 O O   . HOH E 3 .   ? -23.01164 14.26294  -37.98674 1.000 20.17488 ? 524 HOH A O   1 
HETATM 4581 O O   . HOH E 3 .   ? -15.69104 14.76513  -27.66458 1.000 10.07130 ? 525 HOH A O   1 
HETATM 4582 O O   . HOH E 3 .   ? -26.86658 -1.67392  -26.04755 1.000 6.41504  ? 526 HOH A O   1 
HETATM 4583 O O   . HOH E 3 .   ? -32.92124 -1.88593  -25.15942 1.000 9.79422  ? 527 HOH A O   1 
HETATM 4584 O O   . HOH E 3 .   ? -0.31364  12.32723  -21.19751 1.000 16.60203 ? 528 HOH A O   1 
HETATM 4585 O O   . HOH E 3 .   ? -12.08513 -3.46557  -18.53183 1.000 9.74746  ? 529 HOH A O   1 
HETATM 4586 O O   . HOH E 3 .   ? -39.47695 10.02370  -27.58915 1.000 14.54313 ? 530 HOH A O   1 
HETATM 4587 O O   . HOH E 3 .   ? -7.97118  22.81864  -21.00927 1.000 32.53200 ? 531 HOH A O   1 
HETATM 4588 O O   . HOH E 3 .   ? -22.85640 16.75197  -27.04322 1.000 11.97675 ? 532 HOH A O   1 
HETATM 4589 O O   . HOH E 3 .   ? -2.59899  5.25068   -42.20939 1.000 10.86859 ? 533 HOH A O   1 
HETATM 4590 O O   . HOH E 3 .   ? 15.75351  11.98949  -50.98341 1.000 9.37777  ? 534 HOH A O   1 
HETATM 4591 O O   . HOH E 3 .   ? -12.07764 14.45989  -37.24152 1.000 23.03379 ? 535 HOH A O   1 
HETATM 4592 O O   . HOH E 3 .   ? 0.66805   7.97313   -22.98932 1.000 8.69712  ? 536 HOH A O   1 
HETATM 4593 O O   . HOH E 3 .   ? -9.62330  11.93781  -35.90494 1.000 13.93162 ? 537 HOH A O   1 
HETATM 4594 O O   . HOH E 3 .   ? 14.70891  15.89380  -46.24183 1.000 10.91758 ? 538 HOH A O   1 
HETATM 4595 O O   . HOH E 3 .   ? -2.40129  11.28600  -22.82623 1.000 8.86172  ? 539 HOH A O   1 
HETATM 4596 O O   . HOH E 3 .   ? 1.13506   10.74936  -42.18467 1.000 8.59989  ? 540 HOH A O   1 
HETATM 4597 O O   . HOH E 3 .   ? -15.56598 6.22228   -18.08197 1.000 5.40658  ? 541 HOH A O   1 
HETATM 4598 O O   . HOH E 3 .   ? -40.48944 16.51929  -18.11605 1.000 25.24810 ? 542 HOH A O   1 
HETATM 4599 O O   . HOH E 3 .   ? 16.557    -8.780    -29.711   1.000 17.04714 ? 543 HOH A O   1 
HETATM 4600 O O   . HOH E 3 .   ? 26.01542  11.83986  -41.22975 1.000 23.09648 ? 544 HOH A O   1 
HETATM 4601 O O   . HOH E 3 .   ? -22.66794 -1.43613  -17.71932 1.000 9.01310  ? 545 HOH A O   1 
HETATM 4602 O O   . HOH E 3 .   ? -27.12525 19.98796  -7.77675  1.000 26.60088 ? 546 HOH A O   1 
HETATM 4603 O O   . HOH E 3 .   ? 15.77944  -0.60815  -42.57963 1.000 7.04360  ? 547 HOH A O   1 
HETATM 4604 O O   . HOH E 3 .   ? -0.33573  12.21794  -38.13301 1.000 11.63412 ? 548 HOH A O   1 
HETATM 4605 O O   . HOH E 3 .   ? -4.73988  1.99656   -28.60851 1.000 5.68825  ? 549 HOH A O   1 
HETATM 4606 O O   . HOH E 3 .   ? 4.75777   21.73984  -41.29023 1.000 18.99908 ? 550 HOH A O   1 
HETATM 4607 O O   . HOH E 3 .   ? 8.01711   2.81776   -49.47647 1.000 18.89696 ? 551 HOH A O   1 
HETATM 4608 O O   . HOH E 3 .   ? -8.75458  14.63660  -24.68633 1.000 16.10381 ? 552 HOH A O   1 
HETATM 4609 O O   . HOH E 3 .   ? -13.90056 4.34186   -33.46781 1.000 5.55875  ? 553 HOH A O   1 
HETATM 4610 O O   . HOH E 3 .   ? -20.69124 -4.53207  -36.02835 1.000 14.03616 ? 554 HOH A O   1 
HETATM 4611 O O   . HOH E 3 .   ? 3.72927   9.36176   -37.55890 1.000 6.03710  ? 555 HOH A O   1 
HETATM 4612 O O   . HOH E 3 .   ? -11.62033 -5.74155  -37.25247 1.000 8.48689  ? 556 HOH A O   1 
HETATM 4613 O O   . HOH E 3 .   ? 0.76389   15.22319  -40.38823 1.000 13.84108 ? 557 HOH A O   1 
HETATM 4614 O O   . HOH E 3 .   ? -12.21645 20.98726  -12.22178 1.000 16.62681 ? 558 HOH A O   1 
HETATM 4615 O O   . HOH E 3 .   ? -7.82432  -4.15604  -27.82499 1.000 7.47233  ? 559 HOH A O   1 
HETATM 4616 O O   . HOH E 3 .   ? -25.42996 2.92593   -9.83058  1.000 27.86323 ? 560 HOH A O   1 
HETATM 4617 O O   . HOH E 3 .   ? 8.92017   1.99350   -22.93472 1.000 15.75598 ? 561 HOH A O   1 
HETATM 4618 O O   . HOH E 3 .   ? -21.05280 8.71038   -36.49375 1.000 10.37141 ? 562 HOH A O   1 
HETATM 4619 O O   . HOH E 3 .   ? 8.108     -5.427    -46.433   1.000 9.87884  ? 563 HOH A O   1 
HETATM 4620 O O   . HOH E 3 .   ? -19.26579 6.50964   -10.06474 1.000 24.06728 ? 564 HOH A O   1 
HETATM 4621 O O   . HOH E 3 .   ? -17.91309 10.72141  -38.06035 1.000 14.23137 ? 565 HOH A O   1 
HETATM 4622 O O   . HOH E 3 .   ? 20.73432  4.81327   -40.81774 1.000 8.20163  ? 566 HOH A O   1 
HETATM 4623 O O   . HOH E 3 .   ? -16.89756 23.11661  -17.48707 1.000 23.96726 ? 567 HOH A O   1 
HETATM 4624 O O   . HOH E 3 .   ? -31.69019 16.15034  -23.95057 1.000 15.15753 ? 568 HOH A O   1 
HETATM 4625 O O   . HOH E 3 .   ? 24.82759  14.51109  -38.31304 1.000 19.33560 ? 569 HOH A O   1 
HETATM 4626 O O   . HOH E 3 .   ? -10.74714 1.20084   -40.18391 1.000 10.55092 ? 570 HOH A O   1 
HETATM 4627 O O   . HOH E 3 .   ? -23.95019 18.19841  -33.87483 1.000 25.60371 ? 571 HOH A O   1 
HETATM 4628 O O   . HOH E 3 .   ? -10.74477 -6.24404  -24.43566 1.000 10.89721 ? 572 HOH A O   1 
HETATM 4629 O O   . HOH E 3 .   ? -21.46184 6.29939   -37.60632 1.000 5.02653  ? 573 HOH A O   1 
HETATM 4630 O O   . HOH E 3 .   ? 2.83071   -0.06629  -28.60228 1.000 20.03158 ? 574 HOH A O   1 
HETATM 4631 O O   . HOH E 3 .   ? 18.20382  -6.70637  -21.96025 1.000 22.06395 ? 575 HOH A O   1 
HETATM 4632 O O   . HOH E 3 .   ? 0.19148   11.67178  -34.70976 1.000 8.66169  ? 576 HOH A O   1 
HETATM 4633 O O   . HOH E 3 .   ? 21.16156  0.99868   -43.87979 1.000 5.86067  ? 577 HOH A O   1 
HETATM 4634 O O   . HOH E 3 .   ? 20.49963  13.37765  -20.77357 1.000 32.94622 ? 578 HOH A O   1 
HETATM 4635 O O   . HOH E 3 .   ? -46.30786 6.30646   -17.13097 1.000 33.83753 ? 579 HOH A O   1 
HETATM 4636 O O   . HOH E 3 .   ? 19.90017  6.31175   -42.71391 1.000 8.67735  ? 580 HOH A O   1 
HETATM 4637 O O   . HOH E 3 .   ? 20.05647  7.82759   -45.64235 1.000 5.16233  ? 581 HOH A O   1 
HETATM 4638 O O   . HOH E 3 .   ? 2.25504   15.31719  -29.20004 1.000 14.44721 ? 582 HOH A O   1 
HETATM 4639 O O   . HOH E 3 .   ? 3.02860   1.47125   -45.16379 1.000 19.87699 ? 583 HOH A O   1 
HETATM 4640 O O   . HOH E 3 .   ? 0.36770   14.00522  -35.42553 1.000 21.26795 ? 584 HOH A O   1 
HETATM 4641 O O   . HOH E 3 .   ? -0.85329  -0.71062  -28.72789 1.000 19.71558 ? 585 HOH A O   1 
HETATM 4642 O O   . HOH E 3 .   ? 1.13514   10.39980  -36.85691 1.000 10.88301 ? 586 HOH A O   1 
HETATM 4643 O O   . HOH E 3 .   ? -14.65082 10.54761  -7.14150  1.000 21.27318 ? 587 HOH A O   1 
HETATM 4644 O O   . HOH E 3 .   ? -25.84764 16.72686  -35.29562 1.000 32.04130 ? 588 HOH A O   1 
HETATM 4645 O O   . HOH E 3 .   ? -1.62420  21.87699  -22.71041 1.000 38.13133 ? 589 HOH A O   1 
HETATM 4646 O O   . HOH E 3 .   ? 25.58550  12.81491  -37.05940 1.000 18.99642 ? 590 HOH A O   1 
HETATM 4647 O O   . HOH E 3 .   ? 0.04654   12.70333  -40.89631 1.000 8.17088  ? 591 HOH A O   1 
HETATM 4648 O O   . HOH E 3 .   ? -16.13261 16.82729  -29.62738 1.000 16.65354 ? 592 HOH A O   1 
HETATM 4649 O O   . HOH E 3 .   ? -25.04883 21.12884  -7.97262  1.000 24.81033 ? 593 HOH A O   1 
HETATM 4650 O O   . HOH E 3 .   ? 24.010    -2.235    -33.626   1.000 30.94927 ? 594 HOH A O   1 
HETATM 4651 O O   . HOH E 3 .   ? 19.90242  4.37227   -18.00701 1.000 41.46473 ? 595 HOH A O   1 
HETATM 4652 O O   . HOH E 3 .   ? -31.98653 9.74302   -34.11035 1.000 15.55608 ? 596 HOH A O   1 
HETATM 4653 O O   . HOH E 3 .   ? 20.84949  2.08249   -41.59650 1.000 8.58957  ? 597 HOH A O   1 
HETATM 4654 O O   . HOH E 3 .   ? -14.41193 -6.74910  -14.10413 1.000 26.87401 ? 598 HOH A O   1 
HETATM 4655 O O   . HOH E 3 .   ? 21.19178  11.59136  -47.65747 1.000 8.16700  ? 599 HOH A O   1 
HETATM 4656 O O   . HOH E 3 .   ? -16.14368 -5.65133  -13.13907 1.000 22.91550 ? 600 HOH A O   1 
HETATM 4657 O O   . HOH E 3 .   ? 7.22878   15.54683  -47.51074 1.000 25.51663 ? 601 HOH A O   1 
HETATM 4658 O O   . HOH F 3 .   ? 15.69248  20.24555  9.85414   1.000 31.26652 ? 501 HOH B O   1 
HETATM 4659 O O   . HOH F 3 .   ? 19.77308  -18.34661 -10.32312 1.000 24.59771 ? 502 HOH B O   1 
HETATM 4660 O O   . HOH F 3 .   ? 7.05118   17.54854  -4.18992  1.000 17.76872 ? 503 HOH B O   1 
HETATM 4661 O O   . HOH F 3 .   ? 6.11765   10.48442  -11.92239 1.000 13.25881 ? 504 HOH B O   1 
HETATM 4662 O O   . HOH F 3 .   ? -0.03185  9.61879   -3.86384  1.000 8.31392  ? 505 HOH B O   1 
HETATM 4663 O O   . HOH F 3 .   ? 2.91795   -11.30057 -15.15416 1.000 5.72869  ? 506 HOH B O   1 
HETATM 4664 O O   . HOH F 3 .   ? 1.35420   -0.10079  5.16389   1.000 6.47535  ? 507 HOH B O   1 
HETATM 4665 O O   . HOH F 3 .   ? 16.64521  -0.68142  6.21955   1.000 9.87240  ? 508 HOH B O   1 
HETATM 4666 O O   . HOH F 3 .   ? -8.60102  -2.81593  0.83505   1.000 19.86915 ? 509 HOH B O   1 
HETATM 4667 O O   . HOH F 3 .   ? 13.62778  15.53883  2.06428   1.000 14.88670 ? 510 HOH B O   1 
HETATM 4668 O O   . HOH F 3 .   ? 13.38871  -28.24915 -24.86229 1.000 33.00467 ? 511 HOH B O   1 
HETATM 4669 O O   . HOH F 3 .   ? 11.30776  -0.54210  11.49754  1.000 6.17208  ? 512 HOH B O   1 
HETATM 4670 O O   . HOH F 3 .   ? 21.41812  7.01973   -0.69390  1.000 18.56670 ? 513 HOH B O   1 
HETATM 4671 O O   . HOH F 3 .   ? 12.29413  -11.39365 -2.12608  1.000 15.99033 ? 514 HOH B O   1 
HETATM 4672 O O   . HOH F 3 .   ? -5.01919  8.92142   10.43174  1.000 13.56948 ? 515 HOH B O   1 
HETATM 4673 O O   . HOH F 3 .   ? -2.91813  -4.61149  -7.65809  1.000 8.13554  ? 516 HOH B O   1 
HETATM 4674 O O   . HOH F 3 .   ? 3.62254   22.94535  2.39628   1.000 22.03492 ? 517 HOH B O   1 
HETATM 4675 O O   . HOH F 3 .   ? 4.84429   -6.68472  -16.54700 1.000 20.85712 ? 518 HOH B O   1 
HETATM 4676 O O   . HOH F 3 .   ? -14.19107 4.43207   1.29687   1.000 12.10421 ? 519 HOH B O   1 
HETATM 4677 O O   . HOH F 3 .   ? -6.81406  15.23499  -8.35299  1.000 8.38948  ? 520 HOH B O   1 
HETATM 4678 O O   . HOH F 3 .   ? -8.81835  13.46293  -11.23560 1.000 8.35418  ? 521 HOH B O   1 
HETATM 4679 O O   . HOH F 3 .   ? 18.00609  -5.00834  -3.16366  1.000 14.37743 ? 522 HOH B O   1 
HETATM 4680 O O   . HOH F 3 .   ? -6.227    -29.739   -21.962   1.000 27.30452 ? 523 HOH B O   1 
HETATM 4681 O O   . HOH F 3 .   ? -2.17308  -3.03821  -0.83358  1.000 7.41348  ? 524 HOH B O   1 
HETATM 4682 O O   . HOH F 3 .   ? 1.94542   5.00805   10.73345  1.000 14.54208 ? 525 HOH B O   1 
HETATM 4683 O O   . HOH F 3 .   ? 11.88311  -0.31568  -1.13962  1.000 5.92467  ? 526 HOH B O   1 
HETATM 4684 O O   . HOH F 3 .   ? -17.91107 -1.13307  -1.81774  1.000 24.71876 ? 527 HOH B O   1 
HETATM 4685 O O   . HOH F 3 .   ? 7.95988   -2.64869  -10.17119 1.000 11.44548 ? 528 HOH B O   1 
HETATM 4686 O O   . HOH F 3 .   ? 19.210    6.947     7.931     1.000 13.18191 ? 529 HOH B O   1 
HETATM 4687 O O   . HOH F 3 .   ? 2.80588   -12.68974 -7.16579  1.000 10.39107 ? 530 HOH B O   1 
HETATM 4688 O O   . HOH F 3 .   ? 5.93748   -19.53692 -2.13155  1.000 19.84941 ? 531 HOH B O   1 
HETATM 4689 O O   . HOH F 3 .   ? -0.73010  -5.48110  -12.46839 1.000 15.20855 ? 532 HOH B O   1 
HETATM 4690 O O   . HOH F 3 .   ? 14.38186  20.32599  5.89002   1.000 26.88647 ? 533 HOH B O   1 
HETATM 4691 O O   . HOH F 3 .   ? 22.30833  7.10663   10.12635  1.000 29.39749 ? 534 HOH B O   1 
HETATM 4692 O O   . HOH F 3 .   ? 7.08204   -15.86817 -3.87049  1.000 26.05334 ? 535 HOH B O   1 
HETATM 4693 O O   . HOH F 3 .   ? 7.52825   -7.99343  2.62618   1.000 12.83265 ? 536 HOH B O   1 
HETATM 4694 O O   . HOH F 3 .   ? 16.591    4.149     7.434     1.000 9.09722  ? 537 HOH B O   1 
HETATM 4695 O O   . HOH F 3 .   ? 9.07306   1.60087   16.09798  1.000 5.23043  ? 538 HOH B O   1 
HETATM 4696 O O   . HOH F 3 .   ? 16.03444  -3.48974  -9.29984  1.000 18.34401 ? 539 HOH B O   1 
HETATM 4697 O O   . HOH F 3 .   ? 3.84980   17.33741  19.23382  1.000 16.31692 ? 540 HOH B O   1 
HETATM 4698 O O   . HOH F 3 .   ? 12.05247  -5.84075  3.57080   1.000 3.13880  ? 541 HOH B O   1 
HETATM 4699 O O   . HOH F 3 .   ? -7.40408  13.02231  17.44884  1.000 22.90778 ? 542 HOH B O   1 
HETATM 4700 O O   . HOH F 3 .   ? 26.29279  7.62231   4.82567   1.000 23.29021 ? 543 HOH B O   1 
HETATM 4701 O O   . HOH F 3 .   ? 7.66172   -7.12901  -16.55171 1.000 27.85091 ? 544 HOH B O   1 
HETATM 4702 O O   . HOH F 3 .   ? -11.27307 5.66026   -6.05412  1.000 14.20207 ? 545 HOH B O   1 
HETATM 4703 O O   . HOH F 3 .   ? 7.52590   -17.05604 -8.41360  1.000 13.22263 ? 546 HOH B O   1 
HETATM 4704 O O   . HOH F 3 .   ? -1.30099  -7.58558  -5.00485  1.000 10.35675 ? 547 HOH B O   1 
HETATM 4705 O O   . HOH F 3 .   ? 19.06203  -7.47237  -11.55595 1.000 24.15827 ? 548 HOH B O   1 
HETATM 4706 O O   . HOH F 3 .   ? -10.08906 13.94755  14.97212  1.000 23.93393 ? 549 HOH B O   1 
HETATM 4707 O O   . HOH F 3 .   ? 7.15208   -15.06465 -6.33138  1.000 17.86533 ? 550 HOH B O   1 
HETATM 4708 O O   . HOH F 3 .   ? -9.70967  -6.02511  2.37899   1.000 33.76905 ? 551 HOH B O   1 
HETATM 4709 O O   . HOH F 3 .   ? 6.57965   -13.97074 -2.34251  1.000 20.39141 ? 552 HOH B O   1 
HETATM 4710 O O   . HOH F 3 .   ? 9.17249   4.18368   16.05648  1.000 11.62686 ? 553 HOH B O   1 
HETATM 4711 O O   . HOH F 3 .   ? 3.795     -30.428   -28.572   1.000 28.46099 ? 554 HOH B O   1 
HETATM 4712 O O   . HOH F 3 .   ? 18.94086  8.64110   13.18051  1.000 15.88025 ? 555 HOH B O   1 
HETATM 4713 O O   . HOH F 3 .   ? -2.77832  -4.72697  -14.05559 1.000 12.21266 ? 556 HOH B O   1 
HETATM 4714 O O   . HOH F 3 .   ? 6.69128   5.33276   17.32395  1.000 23.85897 ? 557 HOH B O   1 
HETATM 4715 O O   . HOH F 3 .   ? -8.90834  21.24148  0.74357   1.000 26.42027 ? 558 HOH B O   1 
HETATM 4716 O O   . HOH F 3 .   ? 1.56123   -1.48176  7.35428   1.000 14.31663 ? 559 HOH B O   1 
HETATM 4717 O O   . HOH F 3 .   ? -0.49641  -0.45184  -21.18904 1.000 18.51785 ? 560 HOH B O   1 
HETATM 4718 O O   . HOH F 3 .   ? 16.657    -35.144   -15.514   1.000 18.28744 ? 561 HOH B O   1 
HETATM 4719 O O   . HOH F 3 .   ? 4.59044   -13.79163 -5.97426  1.000 16.46846 ? 562 HOH B O   1 
HETATM 4720 O O   . HOH F 3 .   ? 12.49858  -5.76878  6.46516   1.000 8.62375  ? 563 HOH B O   1 
HETATM 4721 O O   . HOH F 3 .   ? 13.463    -3.283    7.683     1.000 13.93998 ? 564 HOH B O   1 
HETATM 4722 O O   . HOH F 3 .   ? 19.33123  12.55635  20.96169  1.000 26.27374 ? 565 HOH B O   1 
HETATM 4723 O O   . HOH F 3 .   ? -3.14105  -5.54782  -0.12961  1.000 16.53223 ? 566 HOH B O   1 
HETATM 4724 O O   . HOH F 3 .   ? 19.30021  -18.39088 -23.68905 1.000 27.83466 ? 567 HOH B O   1 
HETATM 4725 O O   . HOH F 3 .   ? 22.70961  -17.60877 -19.00606 1.000 33.07516 ? 568 HOH B O   1 
HETATM 4726 O O   . HOH F 3 .   ? 21.87327  -17.70946 -21.33099 1.000 36.27796 ? 569 HOH B O   1 
HETATM 4727 O O   . HOH F 3 .   ? 18.48096  -17.57712 -26.79277 1.000 31.99563 ? 570 HOH B O   1 
# 
