data_8YKN
# 
_entry.id   8YKN 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YKN         pdb_00008ykn 10.2210/pdb8ykn/pdb 
WWPDB D_1300043865 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YKN 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rmsl_2040@163.com 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9511-4219 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, J.'  1 ? 
'Zhang, J.' 2 ? 
'Li, J.'    3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            276 
_citation.language                  ? 
_citation.page_first                133706 
_citation.page_last                 133706 
_citation.title                     
'Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.133706 
_citation.pdbx_database_id_PubMed   38981557 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jiang, H.' 1 ? 
primary 'Li, W.'    2 ? 
primary 'Zhou, X.'  3 ? 
primary 'Zhang, J.' 4 ? 
primary 'Li, J.'    5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Non-structural protein 11'                                                                                  
33491.180 1   ? K90R ? ? 
2 non-polymer syn 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' 
459.583   1   ? ?    ? ? 
3 water       nat water                                                                                                        
18.015    125 ? ?    ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        nsp11 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHS
MQNCVLKLRVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCY
MHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP
LTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVT
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHS
MQNCVLKLRVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCY
MHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP
LTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVT
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' X77 
3 water                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PHE n 
1 3   ARG n 
1 4   LYS n 
1 5   MET n 
1 6   ALA n 
1 7   PHE n 
1 8   PRO n 
1 9   SER n 
1 10  GLY n 
1 11  LYS n 
1 12  VAL n 
1 13  GLU n 
1 14  GLY n 
1 15  CYS n 
1 16  MET n 
1 17  VAL n 
1 18  GLN n 
1 19  VAL n 
1 20  THR n 
1 21  CYS n 
1 22  GLY n 
1 23  THR n 
1 24  THR n 
1 25  THR n 
1 26  LEU n 
1 27  ASN n 
1 28  GLY n 
1 29  LEU n 
1 30  TRP n 
1 31  LEU n 
1 32  ASP n 
1 33  ASP n 
1 34  VAL n 
1 35  VAL n 
1 36  TYR n 
1 37  CYS n 
1 38  PRO n 
1 39  ARG n 
1 40  HIS n 
1 41  VAL n 
1 42  ILE n 
1 43  CYS n 
1 44  THR n 
1 45  SER n 
1 46  GLU n 
1 47  ASP n 
1 48  MET n 
1 49  LEU n 
1 50  ASN n 
1 51  PRO n 
1 52  ASN n 
1 53  TYR n 
1 54  GLU n 
1 55  ASP n 
1 56  LEU n 
1 57  LEU n 
1 58  ILE n 
1 59  ARG n 
1 60  LYS n 
1 61  SER n 
1 62  ASN n 
1 63  HIS n 
1 64  ASN n 
1 65  PHE n 
1 66  LEU n 
1 67  VAL n 
1 68  GLN n 
1 69  ALA n 
1 70  GLY n 
1 71  ASN n 
1 72  VAL n 
1 73  GLN n 
1 74  LEU n 
1 75  ARG n 
1 76  VAL n 
1 77  ILE n 
1 78  GLY n 
1 79  HIS n 
1 80  SER n 
1 81  MET n 
1 82  GLN n 
1 83  ASN n 
1 84  CYS n 
1 85  VAL n 
1 86  LEU n 
1 87  LYS n 
1 88  LEU n 
1 89  ARG n 
1 90  VAL n 
1 91  ASP n 
1 92  THR n 
1 93  ALA n 
1 94  ASN n 
1 95  PRO n 
1 96  LYS n 
1 97  THR n 
1 98  PRO n 
1 99  LYS n 
1 100 TYR n 
1 101 LYS n 
1 102 PHE n 
1 103 VAL n 
1 104 ARG n 
1 105 ILE n 
1 106 GLN n 
1 107 PRO n 
1 108 GLY n 
1 109 GLN n 
1 110 THR n 
1 111 PHE n 
1 112 SER n 
1 113 VAL n 
1 114 LEU n 
1 115 ALA n 
1 116 CYS n 
1 117 TYR n 
1 118 ASN n 
1 119 GLY n 
1 120 SER n 
1 121 PRO n 
1 122 SER n 
1 123 GLY n 
1 124 VAL n 
1 125 TYR n 
1 126 GLN n 
1 127 CYS n 
1 128 ALA n 
1 129 MET n 
1 130 ARG n 
1 131 PRO n 
1 132 ASN n 
1 133 PHE n 
1 134 THR n 
1 135 ILE n 
1 136 LYS n 
1 137 GLY n 
1 138 SER n 
1 139 PHE n 
1 140 LEU n 
1 141 ASN n 
1 142 GLY n 
1 143 SER n 
1 144 CYS n 
1 145 GLY n 
1 146 SER n 
1 147 VAL n 
1 148 GLY n 
1 149 PHE n 
1 150 ASN n 
1 151 ILE n 
1 152 ASP n 
1 153 TYR n 
1 154 ASP n 
1 155 CYS n 
1 156 VAL n 
1 157 SER n 
1 158 PHE n 
1 159 CYS n 
1 160 TYR n 
1 161 MET n 
1 162 HIS n 
1 163 HIS n 
1 164 MET n 
1 165 GLU n 
1 166 LEU n 
1 167 PRO n 
1 168 THR n 
1 169 GLY n 
1 170 VAL n 
1 171 HIS n 
1 172 ALA n 
1 173 GLY n 
1 174 THR n 
1 175 ASP n 
1 176 LEU n 
1 177 GLU n 
1 178 GLY n 
1 179 ASN n 
1 180 PHE n 
1 181 TYR n 
1 182 GLY n 
1 183 PRO n 
1 184 PHE n 
1 185 VAL n 
1 186 ASP n 
1 187 ARG n 
1 188 GLN n 
1 189 THR n 
1 190 ALA n 
1 191 GLN n 
1 192 ALA n 
1 193 ALA n 
1 194 GLY n 
1 195 THR n 
1 196 ASP n 
1 197 THR n 
1 198 THR n 
1 199 ILE n 
1 200 THR n 
1 201 VAL n 
1 202 ASN n 
1 203 VAL n 
1 204 LEU n 
1 205 ALA n 
1 206 TRP n 
1 207 LEU n 
1 208 TYR n 
1 209 ALA n 
1 210 ALA n 
1 211 VAL n 
1 212 ILE n 
1 213 ASN n 
1 214 GLY n 
1 215 ASP n 
1 216 ARG n 
1 217 TRP n 
1 218 PHE n 
1 219 LEU n 
1 220 ASN n 
1 221 ARG n 
1 222 PHE n 
1 223 THR n 
1 224 THR n 
1 225 THR n 
1 226 LEU n 
1 227 ASN n 
1 228 ASP n 
1 229 PHE n 
1 230 ASN n 
1 231 LEU n 
1 232 VAL n 
1 233 ALA n 
1 234 MET n 
1 235 LYS n 
1 236 TYR n 
1 237 ASN n 
1 238 TYR n 
1 239 GLU n 
1 240 PRO n 
1 241 LEU n 
1 242 THR n 
1 243 GLN n 
1 244 ASP n 
1 245 HIS n 
1 246 VAL n 
1 247 ASP n 
1 248 ILE n 
1 249 LEU n 
1 250 GLY n 
1 251 PRO n 
1 252 LEU n 
1 253 SER n 
1 254 ALA n 
1 255 GLN n 
1 256 THR n 
1 257 GLY n 
1 258 ILE n 
1 259 ALA n 
1 260 VAL n 
1 261 LEU n 
1 262 ASP n 
1 263 MET n 
1 264 CYS n 
1 265 ALA n 
1 266 SER n 
1 267 LEU n 
1 268 LYS n 
1 269 GLU n 
1 270 LEU n 
1 271 LEU n 
1 272 GLN n 
1 273 ASN n 
1 274 GLY n 
1 275 MET n 
1 276 ASN n 
1 277 GLY n 
1 278 ARG n 
1 279 THR n 
1 280 ILE n 
1 281 LEU n 
1 282 GLY n 
1 283 SER n 
1 284 ALA n 
1 285 LEU n 
1 286 LEU n 
1 287 GLU n 
1 288 ASP n 
1 289 GLU n 
1 290 PHE n 
1 291 THR n 
1 292 PRO n 
1 293 PHE n 
1 294 ASP n 
1 295 VAL n 
1 296 VAL n 
1 297 ARG n 
1 298 GLN n 
1 299 CYS n 
1 300 SER n 
1 301 GLY n 
1 302 VAL n 
1 303 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   303 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
X77 non-polymer         . 
'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' ? 'C27 H33 N5 O2'  
459.583 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   2   2   GLY GLY A . n 
A 1 2   PHE 2   3   3   PHE PHE A . n 
A 1 3   ARG 3   4   4   ARG ARG A . n 
A 1 4   LYS 4   5   5   LYS LYS A . n 
A 1 5   MET 5   6   6   MET MET A . n 
A 1 6   ALA 6   7   7   ALA ALA A . n 
A 1 7   PHE 7   8   8   PHE PHE A . n 
A 1 8   PRO 8   9   9   PRO PRO A . n 
A 1 9   SER 9   10  10  SER SER A . n 
A 1 10  GLY 10  11  11  GLY GLY A . n 
A 1 11  LYS 11  12  12  LYS LYS A . n 
A 1 12  VAL 12  13  13  VAL VAL A . n 
A 1 13  GLU 13  14  14  GLU GLU A . n 
A 1 14  GLY 14  15  15  GLY GLY A . n 
A 1 15  CYS 15  16  16  CYS CYS A . n 
A 1 16  MET 16  17  17  MET MET A . n 
A 1 17  VAL 17  18  18  VAL VAL A . n 
A 1 18  GLN 18  19  19  GLN GLN A . n 
A 1 19  VAL 19  20  20  VAL VAL A . n 
A 1 20  THR 20  21  21  THR THR A . n 
A 1 21  CYS 21  22  22  CYS CYS A . n 
A 1 22  GLY 22  23  23  GLY GLY A . n 
A 1 23  THR 23  24  24  THR THR A . n 
A 1 24  THR 24  25  25  THR THR A . n 
A 1 25  THR 25  26  26  THR THR A . n 
A 1 26  LEU 26  27  27  LEU LEU A . n 
A 1 27  ASN 27  28  28  ASN ASN A . n 
A 1 28  GLY 28  29  29  GLY GLY A . n 
A 1 29  LEU 29  30  30  LEU LEU A . n 
A 1 30  TRP 30  31  31  TRP TRP A . n 
A 1 31  LEU 31  32  32  LEU LEU A . n 
A 1 32  ASP 32  33  33  ASP ASP A . n 
A 1 33  ASP 33  34  34  ASP ASP A . n 
A 1 34  VAL 34  35  35  VAL VAL A . n 
A 1 35  VAL 35  36  36  VAL VAL A . n 
A 1 36  TYR 36  37  37  TYR TYR A . n 
A 1 37  CYS 37  38  38  CYS CYS A . n 
A 1 38  PRO 38  39  39  PRO PRO A . n 
A 1 39  ARG 39  40  40  ARG ARG A . n 
A 1 40  HIS 40  41  41  HIS HIS A . n 
A 1 41  VAL 41  42  42  VAL VAL A . n 
A 1 42  ILE 42  43  43  ILE ILE A . n 
A 1 43  CYS 43  44  44  CYS CYS A . n 
A 1 44  THR 44  45  45  THR THR A . n 
A 1 45  SER 45  46  46  SER SER A . n 
A 1 46  GLU 46  47  47  GLU GLU A . n 
A 1 47  ASP 47  48  48  ASP ASP A . n 
A 1 48  MET 48  49  49  MET MET A . n 
A 1 49  LEU 49  50  50  LEU LEU A . n 
A 1 50  ASN 50  51  51  ASN ASN A . n 
A 1 51  PRO 51  52  52  PRO PRO A . n 
A 1 52  ASN 52  53  53  ASN ASN A . n 
A 1 53  TYR 53  54  54  TYR TYR A . n 
A 1 54  GLU 54  55  55  GLU GLU A . n 
A 1 55  ASP 55  56  56  ASP ASP A . n 
A 1 56  LEU 56  57  57  LEU LEU A . n 
A 1 57  LEU 57  58  58  LEU LEU A . n 
A 1 58  ILE 58  59  59  ILE ILE A . n 
A 1 59  ARG 59  60  60  ARG ARG A . n 
A 1 60  LYS 60  61  61  LYS LYS A . n 
A 1 61  SER 61  62  62  SER SER A . n 
A 1 62  ASN 62  63  63  ASN ASN A . n 
A 1 63  HIS 63  64  64  HIS HIS A . n 
A 1 64  ASN 64  65  65  ASN ASN A . n 
A 1 65  PHE 65  66  66  PHE PHE A . n 
A 1 66  LEU 66  67  67  LEU LEU A . n 
A 1 67  VAL 67  68  68  VAL VAL A . n 
A 1 68  GLN 68  69  69  GLN GLN A . n 
A 1 69  ALA 69  70  70  ALA ALA A . n 
A 1 70  GLY 70  71  71  GLY GLY A . n 
A 1 71  ASN 71  72  72  ASN ASN A . n 
A 1 72  VAL 72  73  73  VAL VAL A . n 
A 1 73  GLN 73  74  74  GLN GLN A . n 
A 1 74  LEU 74  75  75  LEU LEU A . n 
A 1 75  ARG 75  76  76  ARG ARG A . n 
A 1 76  VAL 76  77  77  VAL VAL A . n 
A 1 77  ILE 77  78  78  ILE ILE A . n 
A 1 78  GLY 78  79  79  GLY GLY A . n 
A 1 79  HIS 79  80  80  HIS HIS A . n 
A 1 80  SER 80  81  81  SER SER A . n 
A 1 81  MET 81  82  82  MET MET A . n 
A 1 82  GLN 82  83  83  GLN GLN A . n 
A 1 83  ASN 83  84  84  ASN ASN A . n 
A 1 84  CYS 84  85  85  CYS CYS A . n 
A 1 85  VAL 85  86  86  VAL VAL A . n 
A 1 86  LEU 86  87  87  LEU LEU A . n 
A 1 87  LYS 87  88  88  LYS LYS A . n 
A 1 88  LEU 88  89  89  LEU LEU A . n 
A 1 89  ARG 89  90  90  ARG ARG A . n 
A 1 90  VAL 90  91  91  VAL VAL A . n 
A 1 91  ASP 91  92  92  ASP ASP A . n 
A 1 92  THR 92  93  93  THR THR A . n 
A 1 93  ALA 93  94  94  ALA ALA A . n 
A 1 94  ASN 94  95  95  ASN ASN A . n 
A 1 95  PRO 95  96  96  PRO PRO A . n 
A 1 96  LYS 96  97  97  LYS LYS A . n 
A 1 97  THR 97  98  98  THR THR A . n 
A 1 98  PRO 98  99  99  PRO PRO A . n 
A 1 99  LYS 99  100 100 LYS LYS A . n 
A 1 100 TYR 100 101 101 TYR TYR A . n 
A 1 101 LYS 101 102 102 LYS LYS A . n 
A 1 102 PHE 102 103 103 PHE PHE A . n 
A 1 103 VAL 103 104 104 VAL VAL A . n 
A 1 104 ARG 104 105 105 ARG ARG A . n 
A 1 105 ILE 105 106 106 ILE ILE A . n 
A 1 106 GLN 106 107 107 GLN GLN A . n 
A 1 107 PRO 107 108 108 PRO PRO A . n 
A 1 108 GLY 108 109 109 GLY GLY A . n 
A 1 109 GLN 109 110 110 GLN GLN A . n 
A 1 110 THR 110 111 111 THR THR A . n 
A 1 111 PHE 111 112 112 PHE PHE A . n 
A 1 112 SER 112 113 113 SER SER A . n 
A 1 113 VAL 113 114 114 VAL VAL A . n 
A 1 114 LEU 114 115 115 LEU LEU A . n 
A 1 115 ALA 115 116 116 ALA ALA A . n 
A 1 116 CYS 116 117 117 CYS CYS A . n 
A 1 117 TYR 117 118 118 TYR TYR A . n 
A 1 118 ASN 118 119 119 ASN ASN A . n 
A 1 119 GLY 119 120 120 GLY GLY A . n 
A 1 120 SER 120 121 121 SER SER A . n 
A 1 121 PRO 121 122 122 PRO PRO A . n 
A 1 122 SER 122 123 123 SER SER A . n 
A 1 123 GLY 123 124 124 GLY GLY A . n 
A 1 124 VAL 124 125 125 VAL VAL A . n 
A 1 125 TYR 125 126 126 TYR TYR A . n 
A 1 126 GLN 126 127 127 GLN GLN A . n 
A 1 127 CYS 127 128 128 CYS CYS A . n 
A 1 128 ALA 128 129 129 ALA ALA A . n 
A 1 129 MET 129 130 130 MET MET A . n 
A 1 130 ARG 130 131 131 ARG ARG A . n 
A 1 131 PRO 131 132 132 PRO PRO A . n 
A 1 132 ASN 132 133 133 ASN ASN A . n 
A 1 133 PHE 133 134 134 PHE PHE A . n 
A 1 134 THR 134 135 135 THR THR A . n 
A 1 135 ILE 135 136 136 ILE ILE A . n 
A 1 136 LYS 136 137 137 LYS LYS A . n 
A 1 137 GLY 137 138 138 GLY GLY A . n 
A 1 138 SER 138 139 139 SER SER A . n 
A 1 139 PHE 139 140 140 PHE PHE A . n 
A 1 140 LEU 140 141 141 LEU LEU A . n 
A 1 141 ASN 141 142 142 ASN ASN A . n 
A 1 142 GLY 142 143 143 GLY GLY A . n 
A 1 143 SER 143 144 144 SER SER A . n 
A 1 144 CYS 144 145 145 CYS CYS A . n 
A 1 145 GLY 145 146 146 GLY GLY A . n 
A 1 146 SER 146 147 147 SER SER A . n 
A 1 147 VAL 147 148 148 VAL VAL A . n 
A 1 148 GLY 148 149 149 GLY GLY A . n 
A 1 149 PHE 149 150 150 PHE PHE A . n 
A 1 150 ASN 150 151 151 ASN ASN A . n 
A 1 151 ILE 151 152 152 ILE ILE A . n 
A 1 152 ASP 152 153 153 ASP ASP A . n 
A 1 153 TYR 153 154 154 TYR TYR A . n 
A 1 154 ASP 154 155 155 ASP ASP A . n 
A 1 155 CYS 155 156 156 CYS CYS A . n 
A 1 156 VAL 156 157 157 VAL VAL A . n 
A 1 157 SER 157 158 158 SER SER A . n 
A 1 158 PHE 158 159 159 PHE PHE A . n 
A 1 159 CYS 159 160 160 CYS CYS A . n 
A 1 160 TYR 160 161 161 TYR TYR A . n 
A 1 161 MET 161 162 162 MET MET A . n 
A 1 162 HIS 162 163 163 HIS HIS A . n 
A 1 163 HIS 163 164 164 HIS HIS A . n 
A 1 164 MET 164 165 165 MET MET A . n 
A 1 165 GLU 165 166 166 GLU GLU A . n 
A 1 166 LEU 166 167 167 LEU LEU A . n 
A 1 167 PRO 167 168 168 PRO PRO A . n 
A 1 168 THR 168 169 169 THR THR A . n 
A 1 169 GLY 169 170 170 GLY GLY A . n 
A 1 170 VAL 170 171 171 VAL VAL A . n 
A 1 171 HIS 171 172 172 HIS HIS A . n 
A 1 172 ALA 172 173 173 ALA ALA A . n 
A 1 173 GLY 173 174 174 GLY GLY A . n 
A 1 174 THR 174 175 175 THR THR A . n 
A 1 175 ASP 175 176 176 ASP ASP A . n 
A 1 176 LEU 176 177 177 LEU LEU A . n 
A 1 177 GLU 177 178 178 GLU GLU A . n 
A 1 178 GLY 178 179 179 GLY GLY A . n 
A 1 179 ASN 179 180 180 ASN ASN A . n 
A 1 180 PHE 180 181 181 PHE PHE A . n 
A 1 181 TYR 181 182 182 TYR TYR A . n 
A 1 182 GLY 182 183 183 GLY GLY A . n 
A 1 183 PRO 183 184 184 PRO PRO A . n 
A 1 184 PHE 184 185 185 PHE PHE A . n 
A 1 185 VAL 185 186 186 VAL VAL A . n 
A 1 186 ASP 186 187 187 ASP ASP A . n 
A 1 187 ARG 187 188 188 ARG ARG A . n 
A 1 188 GLN 188 189 189 GLN GLN A . n 
A 1 189 THR 189 190 190 THR THR A . n 
A 1 190 ALA 190 191 191 ALA ALA A . n 
A 1 191 GLN 191 192 192 GLN GLN A . n 
A 1 192 ALA 192 193 193 ALA ALA A . n 
A 1 193 ALA 193 194 194 ALA ALA A . n 
A 1 194 GLY 194 195 195 GLY GLY A . n 
A 1 195 THR 195 196 196 THR THR A . n 
A 1 196 ASP 196 197 197 ASP ASP A . n 
A 1 197 THR 197 198 198 THR THR A . n 
A 1 198 THR 198 199 199 THR THR A . n 
A 1 199 ILE 199 200 200 ILE ILE A . n 
A 1 200 THR 200 201 201 THR THR A . n 
A 1 201 VAL 201 202 202 VAL VAL A . n 
A 1 202 ASN 202 203 203 ASN ASN A . n 
A 1 203 VAL 203 204 204 VAL VAL A . n 
A 1 204 LEU 204 205 205 LEU LEU A . n 
A 1 205 ALA 205 206 206 ALA ALA A . n 
A 1 206 TRP 206 207 207 TRP TRP A . n 
A 1 207 LEU 207 208 208 LEU LEU A . n 
A 1 208 TYR 208 209 209 TYR TYR A . n 
A 1 209 ALA 209 210 210 ALA ALA A . n 
A 1 210 ALA 210 211 211 ALA ALA A . n 
A 1 211 VAL 211 212 212 VAL VAL A . n 
A 1 212 ILE 212 213 213 ILE ILE A . n 
A 1 213 ASN 213 214 214 ASN ASN A . n 
A 1 214 GLY 214 215 215 GLY GLY A . n 
A 1 215 ASP 215 216 216 ASP ASP A . n 
A 1 216 ARG 216 217 217 ARG ARG A . n 
A 1 217 TRP 217 218 218 TRP TRP A . n 
A 1 218 PHE 218 219 219 PHE PHE A . n 
A 1 219 LEU 219 220 220 LEU LEU A . n 
A 1 220 ASN 220 221 221 ASN ASN A . n 
A 1 221 ARG 221 222 222 ARG ARG A . n 
A 1 222 PHE 222 223 223 PHE PHE A . n 
A 1 223 THR 223 224 224 THR THR A . n 
A 1 224 THR 224 225 225 THR THR A . n 
A 1 225 THR 225 226 226 THR THR A . n 
A 1 226 LEU 226 227 227 LEU LEU A . n 
A 1 227 ASN 227 228 228 ASN ASN A . n 
A 1 228 ASP 228 229 229 ASP ASP A . n 
A 1 229 PHE 229 230 230 PHE PHE A . n 
A 1 230 ASN 230 231 231 ASN ASN A . n 
A 1 231 LEU 231 232 232 LEU LEU A . n 
A 1 232 VAL 232 233 233 VAL VAL A . n 
A 1 233 ALA 233 234 234 ALA ALA A . n 
A 1 234 MET 234 235 235 MET MET A . n 
A 1 235 LYS 235 236 236 LYS LYS A . n 
A 1 236 TYR 236 237 237 TYR TYR A . n 
A 1 237 ASN 237 238 238 ASN ASN A . n 
A 1 238 TYR 238 239 239 TYR TYR A . n 
A 1 239 GLU 239 240 240 GLU GLU A . n 
A 1 240 PRO 240 241 241 PRO PRO A . n 
A 1 241 LEU 241 242 242 LEU LEU A . n 
A 1 242 THR 242 243 243 THR THR A . n 
A 1 243 GLN 243 244 244 GLN GLN A . n 
A 1 244 ASP 244 245 245 ASP ASP A . n 
A 1 245 HIS 245 246 246 HIS HIS A . n 
A 1 246 VAL 246 247 247 VAL VAL A . n 
A 1 247 ASP 247 248 248 ASP ASP A . n 
A 1 248 ILE 248 249 249 ILE ILE A . n 
A 1 249 LEU 249 250 250 LEU LEU A . n 
A 1 250 GLY 250 251 251 GLY GLY A . n 
A 1 251 PRO 251 252 252 PRO PRO A . n 
A 1 252 LEU 252 253 253 LEU LEU A . n 
A 1 253 SER 253 254 254 SER SER A . n 
A 1 254 ALA 254 255 255 ALA ALA A . n 
A 1 255 GLN 255 256 256 GLN GLN A . n 
A 1 256 THR 256 257 257 THR THR A . n 
A 1 257 GLY 257 258 258 GLY GLY A . n 
A 1 258 ILE 258 259 259 ILE ILE A . n 
A 1 259 ALA 259 260 260 ALA ALA A . n 
A 1 260 VAL 260 261 261 VAL VAL A . n 
A 1 261 LEU 261 262 262 LEU LEU A . n 
A 1 262 ASP 262 263 263 ASP ASP A . n 
A 1 263 MET 263 264 264 MET MET A . n 
A 1 264 CYS 264 265 265 CYS CYS A . n 
A 1 265 ALA 265 266 266 ALA ALA A . n 
A 1 266 SER 266 267 267 SER SER A . n 
A 1 267 LEU 267 268 268 LEU LEU A . n 
A 1 268 LYS 268 269 269 LYS LYS A . n 
A 1 269 GLU 269 270 270 GLU GLU A . n 
A 1 270 LEU 270 271 271 LEU LEU A . n 
A 1 271 LEU 271 272 272 LEU LEU A . n 
A 1 272 GLN 272 273 273 GLN GLN A . n 
A 1 273 ASN 273 274 274 ASN ASN A . n 
A 1 274 GLY 274 275 275 GLY GLY A . n 
A 1 275 MET 275 276 276 MET MET A . n 
A 1 276 ASN 276 277 277 ASN ASN A . n 
A 1 277 GLY 277 278 278 GLY GLY A . n 
A 1 278 ARG 278 279 279 ARG ARG A . n 
A 1 279 THR 279 280 280 THR THR A . n 
A 1 280 ILE 280 281 281 ILE ILE A . n 
A 1 281 LEU 281 282 282 LEU LEU A . n 
A 1 282 GLY 282 283 283 GLY GLY A . n 
A 1 283 SER 283 284 284 SER SER A . n 
A 1 284 ALA 284 285 285 ALA ALA A . n 
A 1 285 LEU 285 286 286 LEU LEU A . n 
A 1 286 LEU 286 287 287 LEU LEU A . n 
A 1 287 GLU 287 288 288 GLU GLU A . n 
A 1 288 ASP 288 289 289 ASP ASP A . n 
A 1 289 GLU 289 290 290 GLU GLU A . n 
A 1 290 PHE 290 291 291 PHE PHE A . n 
A 1 291 THR 291 292 292 THR THR A . n 
A 1 292 PRO 292 293 293 PRO PRO A . n 
A 1 293 PHE 293 294 294 PHE PHE A . n 
A 1 294 ASP 294 295 295 ASP ASP A . n 
A 1 295 VAL 295 296 296 VAL VAL A . n 
A 1 296 VAL 296 297 297 VAL VAL A . n 
A 1 297 ARG 297 298 298 ARG ARG A . n 
A 1 298 GLN 298 299 299 GLN GLN A . n 
A 1 299 CYS 299 300 300 CYS CYS A . n 
A 1 300 SER 300 301 301 SER SER A . n 
A 1 301 GLY 301 302 302 GLY GLY A . n 
A 1 302 VAL 302 303 303 VAL VAL A . n 
A 1 303 THR 303 304 304 THR THR A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X77 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X77 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 X77 1   401 1   X77 LIG A . 
C 3 HOH 1   501 48  HOH HOH A . 
C 3 HOH 2   502 126 HOH HOH A . 
C 3 HOH 3   503 76  HOH HOH A . 
C 3 HOH 4   504 75  HOH HOH A . 
C 3 HOH 5   505 32  HOH HOH A . 
C 3 HOH 6   506 70  HOH HOH A . 
C 3 HOH 7   507 38  HOH HOH A . 
C 3 HOH 8   508 73  HOH HOH A . 
C 3 HOH 9   509 12  HOH HOH A . 
C 3 HOH 10  510 29  HOH HOH A . 
C 3 HOH 11  511 60  HOH HOH A . 
C 3 HOH 12  512 108 HOH HOH A . 
C 3 HOH 13  513 91  HOH HOH A . 
C 3 HOH 14  514 62  HOH HOH A . 
C 3 HOH 15  515 57  HOH HOH A . 
C 3 HOH 16  516 90  HOH HOH A . 
C 3 HOH 17  517 14  HOH HOH A . 
C 3 HOH 18  518 31  HOH HOH A . 
C 3 HOH 19  519 4   HOH HOH A . 
C 3 HOH 20  520 23  HOH HOH A . 
C 3 HOH 21  521 16  HOH HOH A . 
C 3 HOH 22  522 15  HOH HOH A . 
C 3 HOH 23  523 45  HOH HOH A . 
C 3 HOH 24  524 72  HOH HOH A . 
C 3 HOH 25  525 101 HOH HOH A . 
C 3 HOH 26  526 7   HOH HOH A . 
C 3 HOH 27  527 114 HOH HOH A . 
C 3 HOH 28  528 3   HOH HOH A . 
C 3 HOH 29  529 6   HOH HOH A . 
C 3 HOH 30  530 30  HOH HOH A . 
C 3 HOH 31  531 109 HOH HOH A . 
C 3 HOH 32  532 54  HOH HOH A . 
C 3 HOH 33  533 115 HOH HOH A . 
C 3 HOH 34  534 47  HOH HOH A . 
C 3 HOH 35  535 24  HOH HOH A . 
C 3 HOH 36  536 81  HOH HOH A . 
C 3 HOH 37  537 119 HOH HOH A . 
C 3 HOH 38  538 84  HOH HOH A . 
C 3 HOH 39  539 71  HOH HOH A . 
C 3 HOH 40  540 19  HOH HOH A . 
C 3 HOH 41  541 55  HOH HOH A . 
C 3 HOH 42  542 110 HOH HOH A . 
C 3 HOH 43  543 11  HOH HOH A . 
C 3 HOH 44  544 13  HOH HOH A . 
C 3 HOH 45  545 39  HOH HOH A . 
C 3 HOH 46  546 2   HOH HOH A . 
C 3 HOH 47  547 89  HOH HOH A . 
C 3 HOH 48  548 63  HOH HOH A . 
C 3 HOH 49  549 1   HOH HOH A . 
C 3 HOH 50  550 116 HOH HOH A . 
C 3 HOH 51  551 34  HOH HOH A . 
C 3 HOH 52  552 68  HOH HOH A . 
C 3 HOH 53  553 5   HOH HOH A . 
C 3 HOH 54  554 22  HOH HOH A . 
C 3 HOH 55  555 113 HOH HOH A . 
C 3 HOH 56  556 33  HOH HOH A . 
C 3 HOH 57  557 122 HOH HOH A . 
C 3 HOH 58  558 98  HOH HOH A . 
C 3 HOH 59  559 102 HOH HOH A . 
C 3 HOH 60  560 112 HOH HOH A . 
C 3 HOH 61  561 61  HOH HOH A . 
C 3 HOH 62  562 42  HOH HOH A . 
C 3 HOH 63  563 100 HOH HOH A . 
C 3 HOH 64  564 86  HOH HOH A . 
C 3 HOH 65  565 25  HOH HOH A . 
C 3 HOH 66  566 52  HOH HOH A . 
C 3 HOH 67  567 37  HOH HOH A . 
C 3 HOH 68  568 20  HOH HOH A . 
C 3 HOH 69  569 17  HOH HOH A . 
C 3 HOH 70  570 8   HOH HOH A . 
C 3 HOH 71  571 28  HOH HOH A . 
C 3 HOH 72  572 58  HOH HOH A . 
C 3 HOH 73  573 50  HOH HOH A . 
C 3 HOH 74  574 40  HOH HOH A . 
C 3 HOH 75  575 27  HOH HOH A . 
C 3 HOH 76  576 51  HOH HOH A . 
C 3 HOH 77  577 18  HOH HOH A . 
C 3 HOH 78  578 64  HOH HOH A . 
C 3 HOH 79  579 125 HOH HOH A . 
C 3 HOH 80  580 69  HOH HOH A . 
C 3 HOH 81  581 36  HOH HOH A . 
C 3 HOH 82  582 83  HOH HOH A . 
C 3 HOH 83  583 78  HOH HOH A . 
C 3 HOH 84  584 118 HOH HOH A . 
C 3 HOH 85  585 74  HOH HOH A . 
C 3 HOH 86  586 44  HOH HOH A . 
C 3 HOH 87  587 107 HOH HOH A . 
C 3 HOH 88  588 56  HOH HOH A . 
C 3 HOH 89  589 67  HOH HOH A . 
C 3 HOH 90  590 9   HOH HOH A . 
C 3 HOH 91  591 96  HOH HOH A . 
C 3 HOH 92  592 21  HOH HOH A . 
C 3 HOH 93  593 46  HOH HOH A . 
C 3 HOH 94  594 53  HOH HOH A . 
C 3 HOH 95  595 82  HOH HOH A . 
C 3 HOH 96  596 10  HOH HOH A . 
C 3 HOH 97  597 94  HOH HOH A . 
C 3 HOH 98  598 105 HOH HOH A . 
C 3 HOH 99  599 49  HOH HOH A . 
C 3 HOH 100 600 35  HOH HOH A . 
C 3 HOH 101 601 65  HOH HOH A . 
C 3 HOH 102 602 59  HOH HOH A . 
C 3 HOH 103 603 106 HOH HOH A . 
C 3 HOH 104 604 97  HOH HOH A . 
C 3 HOH 105 605 41  HOH HOH A . 
C 3 HOH 106 606 92  HOH HOH A . 
C 3 HOH 107 607 79  HOH HOH A . 
C 3 HOH 108 608 77  HOH HOH A . 
C 3 HOH 109 609 103 HOH HOH A . 
C 3 HOH 110 610 124 HOH HOH A . 
C 3 HOH 111 611 99  HOH HOH A . 
C 3 HOH 112 612 87  HOH HOH A . 
C 3 HOH 113 613 117 HOH HOH A . 
C 3 HOH 114 614 104 HOH HOH A . 
C 3 HOH 115 615 88  HOH HOH A . 
C 3 HOH 116 616 43  HOH HOH A . 
C 3 HOH 117 617 80  HOH HOH A . 
C 3 HOH 118 618 66  HOH HOH A . 
C 3 HOH 119 619 85  HOH HOH A . 
C 3 HOH 120 620 120 HOH HOH A . 
C 3 HOH 121 621 111 HOH HOH A . 
C 3 HOH 122 622 95  HOH HOH A . 
C 3 HOH 123 623 123 HOH HOH A . 
C 3 HOH 124 624 26  HOH HOH A . 
C 3 HOH 125 625 121 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.12_2829 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   100.871 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YKN 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     114.172 
_cell.length_a_esd                 ? 
_cell.length_b                     54.387 
_cell.length_b_esd                 ? 
_cell.length_c                     45.470 
_cell.length_c_esd                 ? 
_cell.volume                       277280.182 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YKN 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YKN 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.07 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          40.57 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.12~0.21M PEG3350,20%~24%Na2SO4' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          22.7201199286 
_reflns.entry_id                                       8YKN 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.77 
_reflns.d_resolution_low                               34.43 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26667 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.121 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.77 
_reflns_shell.d_res_low                                     1.82 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1842 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.927 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.7138511645 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YKN 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.77 
_refine.ls_d_res_low                             34.43 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26636 
_refine.ls_number_reflns_R_free                  1328 
_refine.ls_number_reflns_R_work                  25308 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.9193003305 
_refine.ls_percent_reflns_R_free                 4.98573359363 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.206721528765 
_refine.ls_R_factor_R_free                       0.234460534069 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.205213361349 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36002909153 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.5077954069 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.200472279747 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.77 
_refine_hist.d_res_low                        34.43 
_refine_hist.number_atoms_solvent             125 
_refine_hist.number_atoms_total               2502 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2343 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00677100747397 ? 2432 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.00014521318    ? 3308 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0608455547292  ? 370  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00583396067418 ? 429  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.4395477981    ? 1417 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.77   1.8387 . . 127 2585 91.0984212294 . . . . 0.265574688733 . . . . . . . . . . . 0.302110703549 
'X-RAY DIFFRACTION' 1.8387 1.9224 . . 151 2811 99.697071693  . . . . 0.245886751439 . . . . . . . . . . . 0.302736675207 
'X-RAY DIFFRACTION' 1.9224 2.0237 . . 141 2825 99.8317064961 . . . . 0.223842387653 . . . . . . . . . . . 0.277783952938 
'X-RAY DIFFRACTION' 2.0237 2.1505 . . 129 2847 99.8657718121 . . . . 0.223261483511 . . . . . . . . . . . 0.259358022401 
'X-RAY DIFFRACTION' 2.1505 2.3165 . . 143 2822 99.9325918436 . . . . 0.221445937306 . . . . . . . . . . . 0.274339022956 
'X-RAY DIFFRACTION' 2.3165 2.5496 . . 170 2835 100.0         . . . . 0.224375687516 . . . . . . . . . . . 0.261222609351 
'X-RAY DIFFRACTION' 2.5496 2.9183 . . 168 2796 100.0         . . . . 0.221467803596 . . . . . . . . . . . 0.265778554501 
'X-RAY DIFFRACTION' 2.9183 3.6761 . . 136 2885 99.9669093316 . . . . 0.198077185473 . . . . . . . . . . . 0.226273609533 
'X-RAY DIFFRACTION' 3.6761 34.43  . . 163 2902 99.8371335505 . . . . 0.1750242704   . . . . . . . . . . . 0.182862797178 
# 
_struct.entry_id                     8YKN 
_struct.title                        'Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with X77' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YKN 
_struct_keywords.text            'VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHS
MQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCY
MHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP
LTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVT
;
_struct_ref.pdbx_align_begin           3265 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YKN 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 303 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC1 
_struct_ref_seq.db_align_beg                  3265 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3567 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       304 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8YKN 
_struct_ref_seq_dif.mon_id                       ARG 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      89 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTC1 
_struct_ref_seq_dif.db_mon_id                    LYS 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3353 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            90 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2550  ? 
1 MORE         -14   ? 
1 'SSA (A^2)'  25440 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? GLY A 14  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 40  ? CYS A 43  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 44  ? MET A 48  ? THR A 45  MET A 49  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 52  ? LYS A 60  ? ASN A 53  LYS A 61  1 ? 9  
HELX_P HELX_P5  AA5 SER A 61  ? HIS A 63  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 199 ? ASN A 213 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 225 ? TYR A 236 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 242 ? LEU A 249 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 249 ? GLY A 257 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 259 ? GLY A 274 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 291 ? CYS A 299 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 72  ? LEU A 74  ? VAL A 73  LEU A 75  
AA1 2 PHE A 65  ? ALA A 69  ? PHE A 66  ALA A 70  
AA1 3 MET A 16  ? CYS A 21  ? MET A 17  CYS A 22  
AA1 4 THR A 24  ? LEU A 31  ? THR A 25  LEU A 32  
AA1 5 VAL A 34  ? PRO A 38  ? VAL A 35  PRO A 39  
AA1 6 VAL A 85  ? VAL A 90  ? VAL A 86  VAL A 91  
AA1 7 VAL A 76  ? GLN A 82  ? VAL A 77  GLN A 83  
AA2 1 TYR A 100 ? PHE A 102 ? TYR A 101 PHE A 103 
AA2 2 CYS A 155 ? GLU A 165 ? CYS A 156 GLU A 166 
AA2 3 VAL A 147 ? ASP A 152 ? VAL A 148 ASP A 153 
AA2 4 THR A 110 ? TYR A 117 ? THR A 111 TYR A 118 
AA2 5 SER A 120 ? ALA A 128 ? SER A 121 ALA A 129 
AA3 1 TYR A 100 ? PHE A 102 ? TYR A 101 PHE A 103 
AA3 2 CYS A 155 ? GLU A 165 ? CYS A 156 GLU A 166 
AA3 3 HIS A 171 ? THR A 174 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 72  ? O VAL A 73  N ALA A 69  ? N ALA A 70  
AA1 2 3 O LEU A 66  ? O LEU A 67  N THR A 20  ? N THR A 21  
AA1 3 4 N VAL A 19  ? N VAL A 20  O LEU A 26  ? O LEU A 27  
AA1 4 5 N LEU A 29  ? N LEU A 30  O TYR A 36  ? O TYR A 37  
AA1 5 6 N VAL A 35  ? N VAL A 36  O LEU A 88  ? O LEU A 89  
AA1 6 7 O ARG A 89  ? O ARG A 90  N ILE A 77  ? N ILE A 78  
AA2 1 2 N LYS A 101 ? N LYS A 102 O PHE A 158 ? O PHE A 159 
AA2 2 3 O SER A 157 ? O SER A 158 N ASN A 150 ? N ASN A 151 
AA2 3 4 O PHE A 149 ? O PHE A 150 N SER A 112 ? N SER A 113 
AA2 4 5 N ALA A 115 ? N ALA A 116 O SER A 122 ? O SER A 123 
AA3 1 2 N LYS A 101 ? N LYS A 102 O PHE A 158 ? O PHE A 159 
AA3 2 3 N MET A 164 ? N MET A 165 O ALA A 172 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   8YKN 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   NH2 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ARG 
_pdbx_validate_close_contact.auth_seq_id_1    298 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    501 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.09 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 52.94   -131.14 
2 1 ASN A 51  ? ? -150.05 73.43   
3 1 ASN A 84  ? ? 51.11   -119.61 
4 1 TYR A 154 ? ? 49.85   -93.97  
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     590 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   C 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
X77 C02  C N N 391 
X77 C04  C N R 392 
X77 C05  C N N 393 
X77 C07  C N N 394 
X77 C08  C N N 395 
X77 C09  C N N 396 
X77 C10  C N N 397 
X77 C11  C N N 398 
X77 C12  C N N 399 
X77 C14  C Y N 400 
X77 C15  C Y N 401 
X77 C16  C Y N 402 
X77 C17  C Y N 403 
X77 C19  C Y N 404 
X77 C20  C Y N 405 
X77 C21  C Y N 406 
X77 C22  C Y N 407 
X77 C23  C Y N 408 
X77 C24  C N N 409 
X77 C25  C N N 410 
X77 C26  C N N 411 
X77 C27  C N N 412 
X77 C28  C Y N 413 
X77 C29  C Y N 414 
X77 C30  C Y N 415 
X77 C31  C Y N 416 
X77 C33  C Y N 417 
X77 N03  N N N 418 
X77 N06  N N N 419 
X77 N18  N Y N 420 
X77 N32  N Y N 421 
X77 N34  N Y N 422 
X77 O01  O N N 423 
X77 O13  O N N 424 
X77 H041 H N N 425 
X77 H071 H N N 426 
X77 H081 H N N 427 
X77 H082 H N N 428 
X77 H091 H N N 429 
X77 H092 H N N 430 
X77 H101 H N N 431 
X77 H102 H N N 432 
X77 H112 H N N 433 
X77 H111 H N N 434 
X77 H121 H N N 435 
X77 H122 H N N 436 
X77 H151 H N N 437 
X77 H161 H N N 438 
X77 H171 H N N 439 
X77 H191 H N N 440 
X77 H211 H N N 441 
X77 H221 H N N 442 
X77 H251 H N N 443 
X77 H252 H N N 444 
X77 H253 H N N 445 
X77 H261 H N N 446 
X77 H263 H N N 447 
X77 H262 H N N 448 
X77 H272 H N N 449 
X77 H273 H N N 450 
X77 H271 H N N 451 
X77 H281 H N N 452 
X77 H291 H N N 453 
X77 H311 H N N 454 
X77 H331 H N N 455 
X77 H061 H N N 456 
X77 H1   H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
X77 C33 N32  sing Y N 376 
X77 C33 N34  doub Y N 377 
X77 N32 C31  sing Y N 378 
X77 N34 C30  sing Y N 379 
X77 C31 C30  doub Y N 380 
X77 C30 C02  sing N N 381 
X77 C27 C24  sing N N 382 
X77 C02 O01  doub N N 383 
X77 C02 N03  sing N N 384 
X77 C26 C24  sing N N 385 
X77 C28 C29  doub Y N 386 
X77 C28 C23  sing Y N 387 
X77 C24 C23  sing N N 388 
X77 C24 C25  sing N N 389 
X77 C29 C20  sing Y N 390 
X77 C23 C22  doub Y N 391 
X77 C20 N03  sing N N 392 
X77 C20 C21  doub Y N 393 
X77 C22 C21  sing Y N 394 
X77 N03 C04  sing N N 395 
X77 C19 N18  doub Y N 396 
X77 C19 C14  sing Y N 397 
X77 C04 C14  sing N N 398 
X77 C04 C05  sing N N 399 
X77 N18 C17  sing Y N 400 
X77 C14 C15  doub Y N 401 
X77 O13 C05  doub N N 402 
X77 C17 C16  doub Y N 403 
X77 C05 N06  sing N N 404 
X77 C15 C16  sing Y N 405 
X77 N06 C07  sing N N 406 
X77 C12 C07  sing N N 407 
X77 C12 C11  sing N N 408 
X77 C07 C08  sing N N 409 
X77 C11 C10  sing N N 410 
X77 C08 C09  sing N N 411 
X77 C10 C09  sing N N 412 
X77 C04 H041 sing N N 413 
X77 C07 H071 sing N N 414 
X77 C08 H081 sing N N 415 
X77 C08 H082 sing N N 416 
X77 C09 H091 sing N N 417 
X77 C09 H092 sing N N 418 
X77 C10 H101 sing N N 419 
X77 C10 H102 sing N N 420 
X77 C11 H112 sing N N 421 
X77 C11 H111 sing N N 422 
X77 C12 H121 sing N N 423 
X77 C12 H122 sing N N 424 
X77 C15 H151 sing N N 425 
X77 C16 H161 sing N N 426 
X77 C17 H171 sing N N 427 
X77 C19 H191 sing N N 428 
X77 C21 H211 sing N N 429 
X77 C22 H221 sing N N 430 
X77 C25 H251 sing N N 431 
X77 C25 H252 sing N N 432 
X77 C25 H253 sing N N 433 
X77 C26 H261 sing N N 434 
X77 C26 H263 sing N N 435 
X77 C26 H262 sing N N 436 
X77 C27 H272 sing N N 437 
X77 C27 H273 sing N N 438 
X77 C27 H271 sing N N 439 
X77 C28 H281 sing N N 440 
X77 C29 H291 sing N N 441 
X77 C31 H311 sing N N 442 
X77 C33 H331 sing N N 443 
X77 N06 H061 sing N N 444 
X77 N32 H1   sing N N 445 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7C2Q 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YKN 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008759 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001682 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018387 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022394 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY A 1 1   ? -3.83390 9.19462   -9.30900  1.000 32.30315 ? 2   GLY A N   1 
ATOM   2    C CA  . GLY A 1 1   ? -3.63839 7.81221   -9.71069  1.000 34.50431 ? 2   GLY A CA  1 
ATOM   3    C C   . GLY A 1 1   ? -2.35525 7.18378   -9.16609  1.000 33.65618 ? 2   GLY A C   1 
ATOM   4    O O   . GLY A 1 1   ? -2.39568 6.14130   -8.51247  1.000 32.13761 ? 2   GLY A O   1 
ATOM   5    N N   . PHE A 1 2   ? -1.21528 7.81491   -9.45378  1.000 34.36095 ? 3   PHE A N   1 
ATOM   6    C CA  . PHE A 1 2   ? 0.07787  7.29360   -9.02232  1.000 29.88657 ? 3   PHE A CA  1 
ATOM   7    C C   . PHE A 1 2   ? 0.15126  7.27631   -7.49677  1.000 31.66548 ? 3   PHE A C   1 
ATOM   8    O O   . PHE A 1 2   ? -0.16518 8.27113   -6.83648  1.000 31.83981 ? 3   PHE A O   1 
ATOM   9    C CB  . PHE A 1 2   ? 1.19214  8.15933   -9.62222  1.000 32.10804 ? 3   PHE A CB  1 
ATOM   10   C CG  . PHE A 1 2   ? 2.57907  7.62755   -9.39695  1.000 26.87087 ? 3   PHE A CG  1 
ATOM   11   C CD1 . PHE A 1 2   ? 3.15064  6.73931   -10.29404 1.000 29.34345 ? 3   PHE A CD1 1 
ATOM   12   C CD2 . PHE A 1 2   ? 3.32496  8.03768   -8.30074  1.000 31.12569 ? 3   PHE A CD2 1 
ATOM   13   C CE1 . PHE A 1 2   ? 4.42116  6.24845   -10.09589 1.000 27.35578 ? 3   PHE A CE1 1 
ATOM   14   C CE2 . PHE A 1 2   ? 4.60149  7.54475   -8.09390  1.000 26.05022 ? 3   PHE A CE2 1 
ATOM   15   C CZ  . PHE A 1 2   ? 5.14809  6.65225   -8.99310  1.000 28.84240 ? 3   PHE A CZ  1 
ATOM   16   N N   . ARG A 1 3   ? 0.55736  6.14201   -6.92480  1.000 26.98965 ? 4   ARG A N   1 
ATOM   17   C CA  . ARG A 1 3   ? 0.50038  5.99459   -5.47602  1.000 26.31825 ? 4   ARG A CA  1 
ATOM   18   C C   . ARG A 1 3   ? 1.58078  5.04335   -4.98940  1.000 23.12537 ? 4   ARG A C   1 
ATOM   19   O O   . ARG A 1 3   ? 2.21673  4.33959   -5.76851  1.000 21.97412 ? 4   ARG A O   1 
ATOM   20   C CB  . ARG A 1 3   ? -0.85479 5.45578   -5.03704  1.000 27.07278 ? 4   ARG A CB  1 
ATOM   21   C CG  . ARG A 1 3   ? -1.00746 3.99224   -5.40750  1.000 23.20267 ? 4   ARG A CG  1 
ATOM   22   C CD  . ARG A 1 3   ? -2.33924 3.73697   -6.02996  1.000 23.76299 ? 4   ARG A CD  1 
ATOM   23   N NE  . ARG A 1 3   ? -3.42696 4.03001   -5.10334  1.000 25.21989 ? 4   ARG A NE  1 
ATOM   24   C CZ  . ARG A 1 3   ? -4.55621 4.62429   -5.47093  1.000 27.11814 ? 4   ARG A CZ  1 
ATOM   25   N NH1 . ARG A 1 3   ? -5.51242 4.87221   -4.58321  1.000 28.18102 ? 4   ARG A NH1 1 
ATOM   26   N NH2 . ARG A 1 3   ? -4.71848 4.98290   -6.73366  1.000 26.34419 ? 4   ARG A NH2 1 
ATOM   27   N N   . LYS A 1 4   ? 1.75257  5.00758   -3.67107  1.000 23.47283 ? 5   LYS A N   1 
ATOM   28   C CA  . LYS A 1 4   ? 2.63513  4.01852   -3.06305  1.000 23.25794 ? 5   LYS A CA  1 
ATOM   29   C C   . LYS A 1 4   ? 2.03729  2.62735   -3.24323  1.000 24.75868 ? 5   LYS A C   1 
ATOM   30   O O   . LYS A 1 4   ? 0.85970  2.40807   -2.94905  1.000 25.93902 ? 5   LYS A O   1 
ATOM   31   C CB  . LYS A 1 4   ? 2.83520  4.33349   -1.58213  1.000 27.43171 ? 5   LYS A CB  1 
ATOM   32   C CG  . LYS A 1 4   ? 4.02012  5.26392   -1.31087  1.000 30.83366 ? 5   LYS A CG  1 
ATOM   33   C CD  . LYS A 1 4   ? 3.66537  6.31153   -0.27551  1.000 31.79728 ? 5   LYS A CD  1 
ATOM   34   C CE  . LYS A 1 4   ? 4.85364  7.21476   0.00260   1.000 31.13739 ? 5   LYS A CE  1 
ATOM   35   N NZ  . LYS A 1 4   ? 5.73635  7.17723   -1.18410  1.000 31.30981 ? 5   LYS A NZ  1 
ATOM   36   N N   . MET A 1 5   ? 2.84390  1.68967   -3.73911  1.000 20.02140 ? 6   MET A N   1 
ATOM   37   C CA  . MET A 1 5   ? 2.37093  0.36406   -4.12667  1.000 21.02664 ? 6   MET A CA  1 
ATOM   38   C C   . MET A 1 5   ? 3.31001  -0.66923  -3.53489  1.000 20.26113 ? 6   MET A C   1 
ATOM   39   O O   . MET A 1 5   ? 4.51850  -0.61343  -3.77477  1.000 23.04328 ? 6   MET A O   1 
ATOM   40   C CB  . MET A 1 5   ? 2.33107  0.22000   -5.64714  1.000 20.44214 ? 6   MET A CB  1 
ATOM   41   C CG  . MET A 1 5   ? 1.68564  -1.02788  -6.14155  1.000 24.99474 ? 6   MET A CG  1 
ATOM   42   S SD  . MET A 1 5   ? 1.38950  -0.89743  -7.91491  1.000 37.87544 ? 6   MET A SD  1 
ATOM   43   C CE  . MET A 1 5   ? 0.54468  0.65759   -8.03361  1.000 24.98252 ? 6   MET A CE  1 
ATOM   44   N N   . ALA A 1 6   ? 2.76162  -1.59927  -2.77176  1.000 17.88270 ? 7   ALA A N   1 
ATOM   45   C CA  . ALA A 1 6   ? 3.58493  -2.59168  -2.10661  1.000 20.48571 ? 7   ALA A CA  1 
ATOM   46   C C   . ALA A 1 6   ? 3.71555  -3.82228  -2.98145  1.000 21.30497 ? 7   ALA A C   1 
ATOM   47   O O   . ALA A 1 6   ? 2.95040  -4.01209  -3.92662  1.000 19.39589 ? 7   ALA A O   1 
ATOM   48   C CB  . ALA A 1 6   ? 2.97999  -2.97371  -0.75914  1.000 18.14695 ? 7   ALA A CB  1 
ATOM   49   N N   . PHE A 1 7   ? 4.70259  -4.66787  -2.65457  1.000 18.19898 ? 8   PHE A N   1 
ATOM   50   C CA  . PHE A 1 7   ? 4.77500  -5.96924  -3.30957  1.000 17.68931 ? 8   PHE A CA  1 
ATOM   51   C C   . PHE A 1 7   ? 3.66227  -6.85353  -2.77078  1.000 19.79749 ? 8   PHE A C   1 
ATOM   52   O O   . PHE A 1 7   ? 3.23423  -6.68769  -1.62534  1.000 17.05689 ? 8   PHE A O   1 
ATOM   53   C CB  . PHE A 1 7   ? 6.12061  -6.65355  -3.06878  1.000 23.26136 ? 8   PHE A CB  1 
ATOM   54   C CG  . PHE A 1 7   ? 7.25089  -6.07127  -3.85710  1.000 23.92116 ? 8   PHE A CG  1 
ATOM   55   C CD1 . PHE A 1 7   ? 7.39256  -6.34840  -5.20571  1.000 25.51554 ? 8   PHE A CD1 1 
ATOM   56   C CD2 . PHE A 1 7   ? 8.16963  -5.22925  -3.24642  1.000 23.91285 ? 8   PHE A CD2 1 
ATOM   57   C CE1 . PHE A 1 7   ? 8.44124  -5.79863  -5.93063  1.000 26.77878 ? 8   PHE A CE1 1 
ATOM   58   C CE2 . PHE A 1 7   ? 9.21514  -4.68702  -3.96486  1.000 24.61652 ? 8   PHE A CE2 1 
ATOM   59   C CZ  . PHE A 1 7   ? 9.35280  -4.97687  -5.30506  1.000 26.92102 ? 8   PHE A CZ  1 
ATOM   60   N N   . PRO A 1 8   ? 3.16691  -7.79530  -3.57381  1.000 18.46533 ? 9   PRO A N   1 
ATOM   61   C CA  . PRO A 1 8   ? 2.25143  -8.79580  -3.02561  1.000 20.48803 ? 9   PRO A CA  1 
ATOM   62   C C   . PRO A 1 8   ? 2.93243  -9.50750  -1.86691  1.000 21.35347 ? 9   PRO A C   1 
ATOM   63   O O   . PRO A 1 8   ? 4.12998  -9.79010  -1.91106  1.000 23.35716 ? 9   PRO A O   1 
ATOM   64   C CB  . PRO A 1 8   ? 1.99255  -9.73937  -4.20794  1.000 24.30933 ? 9   PRO A CB  1 
ATOM   65   C CG  . PRO A 1 8   ? 2.42574  -8.96876  -5.42879  1.000 25.89690 ? 9   PRO A CG  1 
ATOM   66   C CD  . PRO A 1 8   ? 3.54733  -8.09331  -4.96475  1.000 22.60787 ? 9   PRO A CD  1 
ATOM   67   N N   . SER A 1 9   ? 2.16690  -9.78190  -0.82292  1.000 19.05597 ? 10  SER A N   1 
ATOM   68   C CA  . SER A 1 9   ? 2.75528  -10.15215 0.45597   1.000 19.12733 ? 10  SER A CA  1 
ATOM   69   C C   . SER A 1 9   ? 2.65914  -11.63779 0.76817   1.000 22.05770 ? 10  SER A C   1 
ATOM   70   O O   . SER A 1 9   ? 3.13270  -12.06196 1.83092   1.000 20.15721 ? 10  SER A O   1 
ATOM   71   C CB  . SER A 1 9   ? 2.09865  -9.35256  1.58103   1.000 20.54041 ? 10  SER A CB  1 
ATOM   72   O OG  . SER A 1 9   ? 0.70466  -9.61534  1.66649   1.000 20.29629 ? 10  SER A OG  1 
ATOM   73   N N   . GLY A 1 10  ? 2.06500  -12.43386 -0.12610  1.000 22.90545 ? 11  GLY A N   1 
ATOM   74   C CA  . GLY A 1 10  ? 1.74067  -13.81232 0.21705   1.000 20.29751 ? 11  GLY A CA  1 
ATOM   75   C C   . GLY A 1 10  ? 2.93950  -14.62341 0.67109   1.000 20.53741 ? 11  GLY A C   1 
ATOM   76   O O   . GLY A 1 10  ? 2.85658  -15.37416 1.64757   1.000 23.50932 ? 11  GLY A O   1 
ATOM   77   N N   . LYS A 1 11  ? 4.06220  -14.50591 -0.04085  1.000 22.60948 ? 12  LYS A N   1 
ATOM   78   C CA  . LYS A 1 11  ? 5.22311  -15.32562 0.29085   1.000 22.98836 ? 12  LYS A CA  1 
ATOM   79   C C   . LYS A 1 11  ? 5.73733  -15.04160 1.69551   1.000 25.36383 ? 12  LYS A C   1 
ATOM   80   O O   . LYS A 1 11  ? 6.25075  -15.94864 2.35698   1.000 25.03768 ? 12  LYS A O   1 
ATOM   81   C CB  . LYS A 1 11  ? 6.33972  -15.09750 -0.72026  1.000 21.08936 ? 12  LYS A CB  1 
ATOM   82   C CG  . LYS A 1 11  ? 5.93129  -15.42417 -2.13287  1.000 29.90672 ? 12  LYS A CG  1 
ATOM   83   C CD  . LYS A 1 11  ? 7.13132  -15.49604 -3.04454  1.000 32.06712 ? 12  LYS A CD  1 
ATOM   84   C CE  . LYS A 1 11  ? 6.83651  -16.40542 -4.23464  1.000 35.33874 ? 12  LYS A CE  1 
ATOM   85   N NZ  . LYS A 1 11  ? 5.80713  -15.78957 -5.12609  1.000 42.74028 ? 12  LYS A NZ  1 
ATOM   86   N N   . VAL A 1 12  ? 5.59962  -13.80212 2.16635   1.000 22.02975 ? 13  VAL A N   1 
ATOM   87   C CA  . VAL A 1 12  ? 6.04526  -13.44859 3.51205   1.000 21.25002 ? 13  VAL A CA  1 
ATOM   88   C C   . VAL A 1 12  ? 4.99419  -13.83213 4.54653   1.000 22.18958 ? 13  VAL A C   1 
ATOM   89   O O   . VAL A 1 12  ? 5.33561  -14.21350 5.67831   1.000 21.98919 ? 13  VAL A O   1 
ATOM   90   C CB  . VAL A 1 12  ? 6.37303  -11.94362 3.55955   1.000 20.43661 ? 13  VAL A CB  1 
ATOM   91   C CG1 . VAL A 1 12  ? 6.92777  -11.53055 4.94393   1.000 19.76632 ? 13  VAL A CG1 1 
ATOM   92   C CG2 . VAL A 1 12  ? 7.36489  -11.60646 2.47369   1.000 20.59673 ? 13  VAL A CG2 1 
ATOM   93   N N   . GLU A 1 13  ? 3.71197  -13.76221 4.17635   1.000 18.80662 ? 14  GLU A N   1 
ATOM   94   C CA  . GLU A 1 13  ? 2.63822  -14.07761 5.11720   1.000 19.98672 ? 14  GLU A CA  1 
ATOM   95   C C   . GLU A 1 13  ? 2.80471  -15.47112 5.70610   1.000 24.14247 ? 14  GLU A C   1 
ATOM   96   O O   . GLU A 1 13  ? 2.55772  -15.68513 6.90099   1.000 21.79307 ? 14  GLU A O   1 
ATOM   97   C CB  . GLU A 1 13  ? 1.28113  -13.97823 4.42362   1.000 22.15606 ? 14  GLU A CB  1 
ATOM   98   C CG  . GLU A 1 13  ? 0.84097  -12.56226 4.09206   1.000 18.95861 ? 14  GLU A CG  1 
ATOM   99   C CD  . GLU A 1 13  ? -0.37284 -12.55668 3.19106   1.000 23.70122 ? 14  GLU A CD  1 
ATOM   100  O OE1 . GLU A 1 13  ? -1.33695 -13.30065 3.47935   1.000 26.84962 ? 14  GLU A OE1 1 
ATOM   101  O OE2 . GLU A 1 13  ? -0.34930 -11.83464 2.18388   1.000 23.33161 ? 14  GLU A OE2 1 
ATOM   102  N N   . GLY A 1 14  ? 3.21918  -16.42082 4.88049   1.000 23.37080 ? 15  GLY A N   1 
ATOM   103  C CA  . GLY A 1 14  ? 3.44459  -17.78547 5.30294   1.000 23.71515 ? 15  GLY A CA  1 
ATOM   104  C C   . GLY A 1 14  ? 4.64257  -17.97992 6.20677   1.000 25.36814 ? 15  GLY A C   1 
ATOM   105  O O   . GLY A 1 14  ? 4.87843  -19.10407 6.65572   1.000 23.78584 ? 15  GLY A O   1 
ATOM   106  N N   . CYS A 1 15  ? 5.40092  -16.91739 6.48826   1.000 22.56542 ? 16  CYS A N   1 
ATOM   107  C CA  . CYS A 1 15  ? 6.55988  -16.98977 7.36944   1.000 20.22884 ? 16  CYS A CA  1 
ATOM   108  C C   . CYS A 1 15  ? 6.34535  -16.38050 8.74887   1.000 24.30658 ? 16  CYS A C   1 
ATOM   109  O O   . CYS A 1 15  ? 7.22420  -16.52787 9.60675   1.000 22.22077 ? 16  CYS A O   1 
ATOM   110  C CB  . CYS A 1 15  ? 7.76626  -16.29785 6.71526   1.000 20.04001 ? 16  CYS A CB  1 
ATOM   111  S SG  . CYS A 1 15  ? 8.23330  -16.98388 5.10479   1.000 29.11220 ? 16  CYS A SG  1 
ATOM   112  N N   . MET A 1 16  ? 5.22730  -15.70221 8.99127   1.000 21.87044 ? 17  MET A N   1 
ATOM   113  C CA  . MET A 1 16  ? 5.05110  -14.92671 10.21285  1.000 22.65867 ? 17  MET A CA  1 
ATOM   114  C C   . MET A 1 16  ? 4.49925  -15.80832 11.32230  1.000 25.71049 ? 17  MET A C   1 
ATOM   115  O O   . MET A 1 16  ? 3.50750  -16.52069 11.13285  1.000 26.50095 ? 17  MET A O   1 
ATOM   116  C CB  . MET A 1 16  ? 4.12656  -13.72521 9.98216   1.000 24.53930 ? 17  MET A CB  1 
ATOM   117  C CG  . MET A 1 16  ? 4.66377  -12.67518 8.99285   1.000 21.22737 ? 17  MET A CG  1 
ATOM   118  S SD  . MET A 1 16  ? 6.43299  -12.31579 9.07145   1.000 22.42798 ? 17  MET A SD  1 
ATOM   119  C CE  . MET A 1 16  ? 6.59255  -11.61263 10.71365  1.000 17.93060 ? 17  MET A CE  1 
ATOM   120  N N   . VAL A 1 17  ? 5.16479  -15.76702 12.47339  1.000 22.51942 ? 18  VAL A N   1 
ATOM   121  C CA  . VAL A 1 17  ? 4.79394  -16.53501 13.64710  1.000 26.97593 ? 18  VAL A CA  1 
ATOM   122  C C   . VAL A 1 17  ? 4.75167  -15.58963 14.83701  1.000 28.88801 ? 18  VAL A C   1 
ATOM   123  O O   . VAL A 1 17  ? 5.22909  -14.45364 14.78761  1.000 22.43809 ? 18  VAL A O   1 
ATOM   124  C CB  . VAL A 1 17  ? 5.76934  -17.69802 13.93108  1.000 23.21305 ? 18  VAL A CB  1 
ATOM   125  C CG1 . VAL A 1 17  ? 5.80832  -18.66653 12.77740  1.000 25.48075 ? 18  VAL A CG1 1 
ATOM   126  C CG2 . VAL A 1 17  ? 7.16277  -17.16833 14.23566  1.000 23.39195 ? 18  VAL A CG2 1 
ATOM   127  N N   . GLN A 1 18  ? 4.16133  -16.08074 15.91340  1.000 25.74758 ? 19  GLN A N   1 
ATOM   128  C CA  . GLN A 1 18  ? 4.11179  -15.37466 17.18162  1.000 24.99455 ? 19  GLN A CA  1 
ATOM   129  C C   . GLN A 1 18  ? 5.20385  -15.92336 18.09141  1.000 26.01093 ? 19  GLN A C   1 
ATOM   130  O O   . GLN A 1 18  ? 5.39251  -17.13890 18.15889  1.000 26.06758 ? 19  GLN A O   1 
ATOM   131  C CB  . GLN A 1 18  ? 2.74595  -15.57401 17.81917  1.000 27.21711 ? 19  GLN A CB  1 
ATOM   132  C CG  . GLN A 1 18  ? 2.46243  -14.65452 18.92998  1.000 29.83842 ? 19  GLN A CG  1 
ATOM   133  C CD  . GLN A 1 18  ? 1.31502  -15.14574 19.75586  1.000 34.74353 ? 19  GLN A CD  1 
ATOM   134  O OE1 . GLN A 1 18  ? 1.22513  -16.33918 20.07319  1.000 39.11157 ? 19  GLN A OE1 1 
ATOM   135  N NE2 . GLN A 1 18  ? 0.41781  -14.24048 20.10538  1.000 36.93076 ? 19  GLN A NE2 1 
ATOM   136  N N   . VAL A 1 19  ? 5.92522  -15.03289 18.76862  1.000 26.11892 ? 20  VAL A N   1 
ATOM   137  C CA  . VAL A 1 19  ? 6.96805  -15.41656 19.71660  1.000 26.27553 ? 20  VAL A CA  1 
ATOM   138  C C   . VAL A 1 19  ? 6.65215  -14.75895 21.04459  1.000 29.08907 ? 20  VAL A C   1 
ATOM   139  O O   . VAL A 1 19  ? 6.54857  -13.52975 21.13271  1.000 28.46212 ? 20  VAL A O   1 
ATOM   140  C CB  . VAL A 1 19  ? 8.38053  -15.02330 19.25094  1.000 24.82595 ? 20  VAL A CB  1 
ATOM   141  C CG1 . VAL A 1 19  ? 9.40461  -15.46256 20.29657  1.000 28.32873 ? 20  VAL A CG1 1 
ATOM   142  C CG2 . VAL A 1 19  ? 8.71453  -15.69033 17.93390  1.000 24.14706 ? 20  VAL A CG2 1 
ATOM   143  N N   . THR A 1 20  ? 6.52861  -15.56733 22.08748  1.000 31.78721 ? 21  THR A N   1 
ATOM   144  C CA  . THR A 1 20  ? 6.25460  -15.04935 23.41371  1.000 30.64325 ? 21  THR A CA  1 
ATOM   145  C C   . THR A 1 20  ? 7.37679  -15.48715 24.34560  1.000 31.94134 ? 21  THR A C   1 
ATOM   146  O O   . THR A 1 20  ? 7.78334  -16.65494 24.33763  1.000 31.81701 ? 21  THR A O   1 
ATOM   147  C CB  . THR A 1 20  ? 4.88026  -15.51540 23.91146  1.000 31.02592 ? 21  THR A CB  1 
ATOM   148  O OG1 . THR A 1 20  ? 3.86063  -14.93454 23.08831  1.000 34.14806 ? 21  THR A OG1 1 
ATOM   149  C CG2 . THR A 1 20  ? 4.65434  -15.07338 25.32652  1.000 33.42029 ? 21  THR A CG2 1 
ATOM   150  N N   . CYS A 1 21  ? 7.92046  -14.53273 25.09318  1.000 33.80202 ? 22  CYS A N   1 
ATOM   151  C CA  . CYS A 1 21  ? 8.93197  -14.81664 26.10481  1.000 33.94698 ? 22  CYS A CA  1 
ATOM   152  C C   . CYS A 1 21  ? 8.47206  -14.14074 27.38276  1.000 35.13140 ? 22  CYS A C   1 
ATOM   153  O O   . CYS A 1 21  ? 8.48312  -12.90873 27.47340  1.000 39.92626 ? 22  CYS A O   1 
ATOM   154  C CB  . CYS A 1 21  ? 10.31816 -14.32533 25.67816  1.000 29.08158 ? 22  CYS A CB  1 
ATOM   155  S SG  . CYS A 1 21  ? 11.65946 -15.01832 26.66445  1.000 41.25132 ? 22  CYS A SG  1 
ATOM   156  N N   . GLY A 1 22  ? 8.06536  -14.94275 28.36061  1.000 40.76366 ? 23  GLY A N   1 
ATOM   157  C CA  . GLY A 1 22  ? 7.49947  -14.37864 29.57136  1.000 39.47213 ? 23  GLY A CA  1 
ATOM   158  C C   . GLY A 1 22  ? 6.16952  -13.72884 29.26090  1.000 38.81219 ? 23  GLY A C   1 
ATOM   159  O O   . GLY A 1 22  ? 5.27696  -14.33864 28.66134  1.000 44.22789 ? 23  GLY A O   1 
ATOM   160  N N   . THR A 1 23  ? 6.03239  -12.47053 29.66432  1.000 40.86574 ? 24  THR A N   1 
ATOM   161  C CA  . THR A 1 23  ? 4.82066  -11.70083 29.43222  1.000 39.83775 ? 24  THR A CA  1 
ATOM   162  C C   . THR A 1 23  ? 4.81993  -10.97489 28.08438  1.000 43.61190 ? 24  THR A C   1 
ATOM   163  O O   . THR A 1 23  ? 3.79415  -10.39729 27.70532  1.000 39.67794 ? 24  THR A O   1 
ATOM   164  C CB  . THR A 1 23  ? 4.63257  -10.69517 30.57836  1.000 46.23470 ? 24  THR A CB  1 
ATOM   165  O OG1 . THR A 1 23  ? 3.33410  -10.09822 30.49756  1.000 56.32100 ? 24  THR A OG1 1 
ATOM   166  C CG2 . THR A 1 23  ? 5.69465  -9.60070  30.52712  1.000 42.36952 ? 24  THR A CG2 1 
ATOM   167  N N   . THR A 1 24  ? 5.92505  -11.00904 27.34204  1.000 41.50570 ? 25  THR A N   1 
ATOM   168  C CA  . THR A 1 24  ? 6.07196  -10.23264 26.11582  1.000 38.28109 ? 25  THR A CA  1 
ATOM   169  C C   . THR A 1 24  ? 5.77026  -11.08017 24.88911  1.000 32.66995 ? 25  THR A C   1 
ATOM   170  O O   . THR A 1 24  ? 6.25968  -12.20439 24.75907  1.000 31.78508 ? 25  THR A O   1 
ATOM   171  C CB  . THR A 1 24  ? 7.48586  -9.66734  25.99252  1.000 36.89024 ? 25  THR A CB  1 
ATOM   172  O OG1 . THR A 1 24  ? 7.79864  -8.91870  27.16844  1.000 37.24649 ? 25  THR A OG1 1 
ATOM   173  C CG2 . THR A 1 24  ? 7.58797  -8.75734  24.76347  1.000 34.88294 ? 25  THR A CG2 1 
ATOM   174  N N   . THR A 1 25  ? 4.98828  -10.52048 23.97333  1.000 31.58976 ? 26  THR A N   1 
ATOM   175  C CA  . THR A 1 25  ? 4.71095  -11.15992 22.69697  1.000 30.98936 ? 26  THR A CA  1 
ATOM   176  C C   . THR A 1 25  ? 5.11373  -10.22907 21.56000  1.000 26.30750 ? 26  THR A C   1 
ATOM   177  O O   . THR A 1 25  ? 4.86631  -9.01774  21.62189  1.000 27.77041 ? 26  THR A O   1 
ATOM   178  C CB  . THR A 1 25  ? 3.23635  -11.53034 22.58621  1.000 33.26510 ? 26  THR A CB  1 
ATOM   179  O OG1 . THR A 1 25  ? 2.94414  -12.56080 23.53658  1.000 39.51043 ? 26  THR A OG1 1 
ATOM   180  C CG2 . THR A 1 25  ? 2.92465  -12.04966 21.21128  1.000 31.78085 ? 26  THR A CG2 1 
ATOM   181  N N   . LEU A 1 26  ? 5.78065  -10.78806 20.55457  1.000 26.43785 ? 27  LEU A N   1 
ATOM   182  C CA  . LEU A 1 26  ? 6.00555  -10.08082 19.29827  1.000 26.98944 ? 27  LEU A CA  1 
ATOM   183  C C   . LEU A 1 26  ? 6.06377  -11.10141 18.16010  1.000 22.29558 ? 27  LEU A C   1 
ATOM   184  O O   . LEU A 1 26  ? 5.70718  -12.27142 18.32866  1.000 26.11329 ? 27  LEU A O   1 
ATOM   185  C CB  . LEU A 1 26  ? 7.26143  -9.20632  19.39160  1.000 25.07821 ? 27  LEU A CB  1 
ATOM   186  C CG  . LEU A 1 26  ? 8.47152  -9.78525  20.12035  1.000 24.81214 ? 27  LEU A CG  1 
ATOM   187  C CD1 . LEU A 1 26  ? 9.09104  -10.91410 19.33179  1.000 23.63318 ? 27  LEU A CD1 1 
ATOM   188  C CD2 . LEU A 1 26  ? 9.48058  -8.66554  20.33899  1.000 19.88304 ? 27  LEU A CD2 1 
ATOM   189  N N   . ASN A 1 27  ? 6.54967  -10.66264 16.99787  1.000 20.81687 ? 28  ASN A N   1 
ATOM   190  C CA  . ASN A 1 27  ? 6.50863  -11.47345 15.78890  1.000 19.03719 ? 28  ASN A CA  1 
ATOM   191  C C   . ASN A 1 27  ? 7.87345  -12.07378 15.49039  1.000 19.27743 ? 28  ASN A C   1 
ATOM   192  O O   . ASN A 1 27  ? 8.91205  -11.51889 15.86374  1.000 19.95952 ? 28  ASN A O   1 
ATOM   193  C CB  . ASN A 1 27  ? 6.05098  -10.63954 14.58212  1.000 19.24590 ? 28  ASN A CB  1 
ATOM   194  C CG  . ASN A 1 27  ? 4.76581  -9.90670  14.84058  1.000 19.48131 ? 28  ASN A CG  1 
ATOM   195  O OD1 . ASN A 1 27  ? 3.68730  -10.49133 14.78423  1.000 22.49718 ? 28  ASN A OD1 1 
ATOM   196  N ND2 . ASN A 1 27  ? 4.86966  -8.62690  15.14140  1.000 19.07635 ? 28  ASN A ND2 1 
ATOM   197  N N   . GLY A 1 28  ? 7.85638  -13.21822 14.81212  1.000 16.62213 ? 29  GLY A N   1 
ATOM   198  C CA  . GLY A 1 28  ? 9.07356  -13.83359 14.33595  1.000 17.09332 ? 29  GLY A CA  1 
ATOM   199  C C   . GLY A 1 28  ? 8.90752  -14.29978 12.90203  1.000 17.16227 ? 29  GLY A C   1 
ATOM   200  O O   . GLY A 1 28  ? 7.79648  -14.48680 12.40534  1.000 18.94397 ? 29  GLY A O   1 
ATOM   201  N N   . LEU A 1 29  ? 10.04358 -14.50689 12.25376  1.000 16.14437 ? 30  LEU A N   1 
ATOM   202  C CA  . LEU A 1 29  ? 10.10940 -14.90603 10.85118  1.000 19.97865 ? 30  LEU A CA  1 
ATOM   203  C C   . LEU A 1 29  ? 10.60648 -16.34463 10.80311  1.000 21.21022 ? 30  LEU A C   1 
ATOM   204  O O   . LEU A 1 29  ? 11.74110 -16.62352 11.20274  1.000 20.40955 ? 30  LEU A O   1 
ATOM   205  C CB  . LEU A 1 29  ? 11.04283 -13.98347 10.07089  1.000 21.57779 ? 30  LEU A CB  1 
ATOM   206  C CG  . LEU A 1 29  ? 11.13939 -14.19358 8.55884   1.000 21.57697 ? 30  LEU A CG  1 
ATOM   207  C CD1 . LEU A 1 29  ? 9.85338  -13.74500 7.91689   1.000 23.24194 ? 30  LEU A CD1 1 
ATOM   208  C CD2 . LEU A 1 29  ? 12.30384 -13.41609 8.01244   1.000 21.59016 ? 30  LEU A CD2 1 
ATOM   209  N N   . TRP A 1 30  ? 9.76887  -17.24029 10.29669  1.000 20.29765 ? 31  TRP A N   1 
ATOM   210  C CA  . TRP A 1 30  ? 10.02706 -18.67984 10.30928  1.000 22.60580 ? 31  TRP A CA  1 
ATOM   211  C C   . TRP A 1 30  ? 10.48747 -19.08662 8.91055   1.000 23.52821 ? 31  TRP A C   1 
ATOM   212  O O   . TRP A 1 30  ? 9.68625  -19.15858 7.97432   1.000 24.94435 ? 31  TRP A O   1 
ATOM   213  C CB  . TRP A 1 30  ? 8.76868  -19.41103 10.76516  1.000 20.40453 ? 31  TRP A CB  1 
ATOM   214  C CG  . TRP A 1 30  ? 8.88562  -20.89589 10.86743  1.000 25.23550 ? 31  TRP A CG  1 
ATOM   215  C CD1 . TRP A 1 30  ? 10.02781 -21.62853 11.03565  1.000 24.62072 ? 31  TRP A CD1 1 
ATOM   216  C CD2 . TRP A 1 30  ? 7.80441  -21.83809 10.80488  1.000 26.79359 ? 31  TRP A CD2 1 
ATOM   217  N NE1 . TRP A 1 30  ? 9.71957  -22.97482 11.07630  1.000 25.65159 ? 31  TRP A NE1 1 
ATOM   218  C CE2 . TRP A 1 30  ? 8.36329  -23.12741 10.95569  1.000 26.05560 ? 31  TRP A CE2 1 
ATOM   219  C CE3 . TRP A 1 30  ? 6.41737  -21.71454 10.64683  1.000 26.24003 ? 31  TRP A CE3 1 
ATOM   220  C CZ2 . TRP A 1 30  ? 7.58367  -24.29198 10.92857  1.000 27.54636 ? 31  TRP A CZ2 1 
ATOM   221  C CZ3 . TRP A 1 30  ? 5.63816  -22.87440 10.62928  1.000 30.35088 ? 31  TRP A CZ3 1 
ATOM   222  C CH2 . TRP A 1 30  ? 6.23182  -24.14371 10.77344  1.000 28.02870 ? 31  TRP A CH2 1 
ATOM   223  N N   . LEU A 1 31  ? 11.79536 -19.28808 8.75732   1.000 19.63396 ? 32  LEU A N   1 
ATOM   224  C CA  . LEU A 1 31  ? 12.39957 -19.74575 7.51082   1.000 20.75739 ? 32  LEU A CA  1 
ATOM   225  C C   . LEU A 1 31  ? 13.11779 -21.06192 7.77300   1.000 26.19988 ? 32  LEU A C   1 
ATOM   226  O O   . LEU A 1 31  ? 13.98144 -21.13330 8.65557   1.000 24.25656 ? 32  LEU A O   1 
ATOM   227  C CB  . LEU A 1 31  ? 13.39441 -18.73031 6.95804   1.000 23.84758 ? 32  LEU A CB  1 
ATOM   228  C CG  . LEU A 1 31  ? 12.80997 -17.35969 6.61794   1.000 22.14605 ? 32  LEU A CG  1 
ATOM   229  C CD1 . LEU A 1 31  ? 13.94567 -16.34468 6.42413   1.000 20.86893 ? 32  LEU A CD1 1 
ATOM   230  C CD2 . LEU A 1 31  ? 11.88556 -17.44935 5.39122   1.000 19.88646 ? 32  LEU A CD2 1 
ATOM   231  N N   . ASP A 1 32  ? 12.78060 -22.09448 7.00398   1.000 26.64399 ? 33  ASP A N   1 
ATOM   232  C CA  . ASP A 1 32  ? 13.33031 -23.43396 7.27188   1.000 24.47509 ? 33  ASP A CA  1 
ATOM   233  C C   . ASP A 1 32  ? 13.04972 -23.75332 8.74121   1.000 23.03640 ? 33  ASP A C   1 
ATOM   234  O O   . ASP A 1 32  ? 11.91921 -23.55320 9.21205   1.000 24.29271 ? 33  ASP A O   1 
ATOM   235  C CB  . ASP A 1 32  ? 14.79605 -23.47062 6.86352   1.000 25.47229 ? 33  ASP A CB  1 
ATOM   236  C CG  . ASP A 1 32  ? 15.00699 -23.13322 5.40064   1.000 32.68992 ? 33  ASP A CG  1 
ATOM   237  O OD1 . ASP A 1 32  ? 14.18736 -23.57097 4.57448   1.000 39.22880 ? 33  ASP A OD1 1 
ATOM   238  O OD2 . ASP A 1 32  ? 16.00221 -22.44890 5.07719   1.000 36.67380 ? 33  ASP A OD2 1 
ATOM   239  N N   . ASP A 1 33  ? 14.03289 -24.20949 9.51685   1.000 24.61475 ? 34  ASP A N   1 
ATOM   240  C CA  . ASP A 1 33  ? 13.77544 -24.57592 10.90071  1.000 28.67313 ? 34  ASP A CA  1 
ATOM   241  C C   . ASP A 1 33  ? 14.31709 -23.53637 11.87794  1.000 27.37810 ? 34  ASP A C   1 
ATOM   242  O O   . ASP A 1 33  ? 14.71648 -23.86795 12.99603  1.000 27.72423 ? 34  ASP A O   1 
ATOM   243  C CB  . ASP A 1 33  ? 14.34913 -25.96011 11.20673  1.000 30.42049 ? 34  ASP A CB  1 
ATOM   244  C CG  . ASP A 1 33  ? 15.85060 -26.03706 11.00172  1.000 36.37081 ? 34  ASP A CG  1 
ATOM   245  O OD1 . ASP A 1 33  ? 16.44137 -25.10561 10.41134  1.000 36.71359 ? 34  ASP A OD1 1 
ATOM   246  O OD2 . ASP A 1 33  ? 16.44651 -27.03857 11.45607  1.000 43.43011 ? 34  ASP A OD2 1 
ATOM   247  N N   . VAL A 1 34  ? 14.32331 -22.26734 11.48200  1.000 24.03529 ? 35  VAL A N   1 
ATOM   248  C CA  . VAL A 1 34  ? 14.81334 -21.20022 12.34430  1.000 23.91491 ? 35  VAL A CA  1 
ATOM   249  C C   . VAL A 1 34  ? 13.75700 -20.10969 12.38323  1.000 25.64454 ? 35  VAL A C   1 
ATOM   250  O O   . VAL A 1 34  ? 13.16022 -19.77485 11.35289  1.000 20.94213 ? 35  VAL A O   1 
ATOM   251  C CB  . VAL A 1 34  ? 16.16555 -20.64384 11.85776  1.000 26.24716 ? 35  VAL A CB  1 
ATOM   252  C CG1 . VAL A 1 34  ? 16.57286 -19.40927 12.67901  1.000 23.30939 ? 35  VAL A CG1 1 
ATOM   253  C CG2 . VAL A 1 34  ? 17.23356 -21.72458 11.93682  1.000 27.71952 ? 35  VAL A CG2 1 
ATOM   254  N N   . VAL A 1 35  ? 13.49373 -19.58414 13.57261  1.000 23.80558 ? 36  VAL A N   1 
ATOM   255  C CA  . VAL A 1 35  ? 12.62636 -18.42235 13.73508  1.000 21.62119 ? 36  VAL A CA  1 
ATOM   256  C C   . VAL A 1 35  ? 13.50345 -17.26013 14.18575  1.000 22.95303 ? 36  VAL A C   1 
ATOM   257  O O   . VAL A 1 35  ? 14.21207 -17.36256 15.19154  1.000 21.79066 ? 36  VAL A O   1 
ATOM   258  C CB  . VAL A 1 35  ? 11.48932 -18.69565 14.72940  1.000 23.78031 ? 36  VAL A CB  1 
ATOM   259  C CG1 . VAL A 1 35  ? 10.77962 -17.42877 15.08258  1.000 20.68935 ? 36  VAL A CG1 1 
ATOM   260  C CG2 . VAL A 1 35  ? 10.48736 -19.72211 14.14523  1.000 23.69769 ? 36  VAL A CG2 1 
ATOM   261  N N   . TYR A 1 36  ? 13.47806 -16.16736 13.42648  1.000 21.14757 ? 37  TYR A N   1 
ATOM   262  C CA  . TYR A 1 36  ? 14.24794 -14.96900 13.72408  1.000 20.42176 ? 37  TYR A CA  1 
ATOM   263  C C   . TYR A 1 36  ? 13.32233 -13.95420 14.38198  1.000 20.24823 ? 37  TYR A C   1 
ATOM   264  O O   . TYR A 1 36  ? 12.17338 -13.80901 13.97033  1.000 18.78438 ? 37  TYR A O   1 
ATOM   265  C CB  . TYR A 1 36  ? 14.83215 -14.36653 12.43864  1.000 18.70173 ? 37  TYR A CB  1 
ATOM   266  C CG  . TYR A 1 36  ? 15.66583 -15.32366 11.61895  1.000 20.87397 ? 37  TYR A CG  1 
ATOM   267  C CD1 . TYR A 1 36  ? 15.06514 -16.33473 10.86813  1.000 22.59929 ? 37  TYR A CD1 1 
ATOM   268  C CD2 . TYR A 1 36  ? 17.05418 -15.21476 11.58308  1.000 21.16233 ? 37  TYR A CD2 1 
ATOM   269  C CE1 . TYR A 1 36  ? 15.81771 -17.21315 10.12079  1.000 22.68337 ? 37  TYR A CE1 1 
ATOM   270  C CE2 . TYR A 1 36  ? 17.81924 -16.09440 10.83270  1.000 23.66677 ? 37  TYR A CE2 1 
ATOM   271  C CZ  . TYR A 1 36  ? 17.19321 -17.08043 10.09830  1.000 24.36355 ? 37  TYR A CZ  1 
ATOM   272  O OH  . TYR A 1 36  ? 17.94184 -17.95638 9.34568   1.000 27.32154 ? 37  TYR A OH  1 
ATOM   273  N N   . CYS A 1 37  ? 13.81195 -13.25455 15.40333  1.000 16.79781 ? 38  CYS A N   1 
ATOM   274  C CA  . CYS A 1 37  ? 12.99712 -12.22824 16.03840  1.000 18.71132 ? 38  CYS A CA  1 
ATOM   275  C C   . CYS A 1 37  ? 13.92329 -11.28169 16.79381  1.000 17.97472 ? 38  CYS A C   1 
ATOM   276  O O   . CYS A 1 37  ? 15.10368 -11.60252 16.99954  1.000 18.33395 ? 38  CYS A O   1 
ATOM   277  C CB  . CYS A 1 37  ? 11.93829 -12.85350 16.96366  1.000 18.61364 ? 38  CYS A CB  1 
ATOM   278  S SG  . CYS A 1 37  ? 12.57710 -13.49959 18.53167  1.000 23.87775 ? 38  CYS A SG  1 
ATOM   279  N N   . PRO A 1 38  ? 13.43985 -10.09003 17.16862  1.000 17.77412 ? 39  PRO A N   1 
ATOM   280  C CA  . PRO A 1 38  ? 14.28688 -9.16047  17.93574  1.000 17.77134 ? 39  PRO A CA  1 
ATOM   281  C C   . PRO A 1 38  ? 14.71424 -9.78516  19.25365  1.000 16.15323 ? 39  PRO A C   1 
ATOM   282  O O   . PRO A 1 38  ? 13.91171 -10.40901 19.95012  1.000 20.75894 ? 39  PRO A O   1 
ATOM   283  C CB  . PRO A 1 38  ? 13.37435 -7.95324  18.17770  1.000 17.13130 ? 39  PRO A CB  1 
ATOM   284  C CG  . PRO A 1 38  ? 12.32678 -8.04290  17.08449  1.000 17.10866 ? 39  PRO A CG  1 
ATOM   285  C CD  . PRO A 1 38  ? 12.10869 -9.52062  16.90082  1.000 18.64431 ? 39  PRO A CD  1 
ATOM   286  N N   . ARG A 1 39  ? 15.98685 -9.60708  19.60512  1.000 18.72683 ? 40  ARG A N   1 
ATOM   287  C CA  . ARG A 1 39  ? 16.44583 -10.19523 20.86500  1.000 19.67682 ? 40  ARG A CA  1 
ATOM   288  C C   . ARG A 1 39  ? 15.83895 -9.51106  22.08279  1.000 18.90311 ? 40  ARG A C   1 
ATOM   289  O O   . ARG A 1 39  ? 15.85998 -10.09904 23.17478  1.000 21.33166 ? 40  ARG A O   1 
ATOM   290  C CB  . ARG A 1 39  ? 17.97266 -10.16046 20.95081  1.000 18.81804 ? 40  ARG A CB  1 
ATOM   291  C CG  . ARG A 1 39  ? 18.53848 -8.79125  21.22430  1.000 20.01892 ? 40  ARG A CG  1 
ATOM   292  C CD  . ARG A 1 39  ? 20.05227 -8.82384  21.43809  1.000 20.39305 ? 40  ARG A CD  1 
ATOM   293  N NE  . ARG A 1 39  ? 20.60017 -7.47330  21.45772  1.000 20.69680 ? 40  ARG A NE  1 
ATOM   294  C CZ  . ARG A 1 39  ? 21.87178 -7.16658  21.72106  1.000 21.45233 ? 40  ARG A CZ  1 
ATOM   295  N NH1 . ARG A 1 39  ? 22.75709 -8.11968  21.97985  1.000 17.95095 ? 40  ARG A NH1 1 
ATOM   296  N NH2 . ARG A 1 39  ? 22.26143 -5.89799  21.72294  1.000 22.31634 ? 40  ARG A NH2 1 
ATOM   297  N N   . HIS A 1 40  ? 15.27159 -8.30509  21.92855  1.000 20.40122 ? 41  HIS A N   1 
ATOM   298  C CA  . HIS A 1 40  ? 14.71271 -7.62756  23.09262  1.000 18.49054 ? 41  HIS A CA  1 
ATOM   299  C C   . HIS A 1 40  ? 13.44591 -8.29370  23.60890  1.000 23.01951 ? 41  HIS A C   1 
ATOM   300  O O   . HIS A 1 40  ? 12.92497 -7.85801  24.63769  1.000 23.06082 ? 41  HIS A O   1 
ATOM   301  C CB  . HIS A 1 40  ? 14.49073 -6.13172  22.81879  1.000 19.52663 ? 41  HIS A CB  1 
ATOM   302  C CG  . HIS A 1 40  ? 13.46113 -5.80495  21.76753  1.000 20.05538 ? 41  HIS A CG  1 
ATOM   303  N ND1 . HIS A 1 40  ? 12.12310 -6.11726  21.90059  1.000 23.21017 ? 41  HIS A ND1 1 
ATOM   304  C CD2 . HIS A 1 40  ? 13.57249 -5.12125  20.60182  1.000 19.62654 ? 41  HIS A CD2 1 
ATOM   305  C CE1 . HIS A 1 40  ? 11.45999 -5.65993  20.84955  1.000 23.47263 ? 41  HIS A CE1 1 
ATOM   306  N NE2 . HIS A 1 40  ? 12.31641 -5.04185  20.05168  1.000 19.67402 ? 41  HIS A NE2 1 
ATOM   307  N N   . VAL A 1 41  ? 12.97579 -9.35870  22.95424  1.000 19.51174 ? 42  VAL A N   1 
ATOM   308  C CA  . VAL A 1 41  ? 11.89275 -10.17484 23.49987  1.000 22.48336 ? 42  VAL A CA  1 
ATOM   309  C C   . VAL A 1 41  ? 12.26259 -10.75986 24.86245  1.000 25.78109 ? 42  VAL A C   1 
ATOM   310  O O   . VAL A 1 41  ? 11.37406 -11.12643 25.63662  1.000 28.42245 ? 42  VAL A O   1 
ATOM   311  C CB  . VAL A 1 41  ? 11.51241 -11.30313 22.51203  1.000 22.78737 ? 42  VAL A CB  1 
ATOM   312  C CG1 . VAL A 1 41  ? 12.51808 -12.45561 22.55236  1.000 20.44817 ? 42  VAL A CG1 1 
ATOM   313  C CG2 . VAL A 1 41  ? 10.09331 -11.79889 22.78362  1.000 24.41170 ? 42  VAL A CG2 1 
ATOM   314  N N   . ILE A 1 42  ? 13.55862 -10.87753 25.17350  1.000 22.24532 ? 43  ILE A N   1 
ATOM   315  C CA  . ILE A 1 42  ? 13.96454 -11.50828 26.43598  1.000 26.00954 ? 43  ILE A CA  1 
ATOM   316  C C   . ILE A 1 42  ? 14.13051 -10.51402 27.57479  1.000 30.88117 ? 43  ILE A C   1 
ATOM   317  O O   . ILE A 1 42  ? 14.47353 -10.92436 28.69449  1.000 32.92482 ? 43  ILE A O   1 
ATOM   318  C CB  . ILE A 1 42  ? 15.26326 -12.32249 26.27090  1.000 25.86737 ? 43  ILE A CB  1 
ATOM   319  C CG1 . ILE A 1 42  ? 16.45970 -11.40815 25.99436  1.000 24.94153 ? 43  ILE A CG1 1 
ATOM   320  C CG2 . ILE A 1 42  ? 15.12040 -13.32011 25.14849  1.000 25.32828 ? 43  ILE A CG2 1 
ATOM   321  C CD1 . ILE A 1 42  ? 17.80116 -12.17762 25.92909  1.000 23.80587 ? 43  ILE A CD1 1 
ATOM   322  N N   . CYS A 1 43  ? 13.89451 -9.22784  27.33488  1.000 28.04804 ? 44  CYS A N   1 
ATOM   323  C CA  . CYS A 1 43  ? 13.94511 -8.23038  28.38879  1.000 33.52523 ? 44  CYS A CA  1 
ATOM   324  C C   . CYS A 1 43  ? 12.69972 -8.28722  29.26536  1.000 38.88033 ? 44  CYS A C   1 
ATOM   325  O O   . CYS A 1 43  ? 11.66600 -8.83849  28.88917  1.000 39.61567 ? 44  CYS A O   1 
ATOM   326  C CB  . CYS A 1 43  ? 14.06557 -6.83158  27.80112  1.000 34.81344 ? 44  CYS A CB  1 
ATOM   327  S SG  . CYS A 1 43  ? 15.67502 -6.50647  27.12352  1.000 48.06805 ? 44  CYS A SG  1 
ATOM   328  N N   . THR A 1 44  ? 12.81940 -7.70684  30.45704  1.000 43.26936 ? 45  THR A N   1 
ATOM   329  C CA  . THR A 1 44  ? 11.68599 -7.37156  31.30628  1.000 38.98952 ? 45  THR A CA  1 
ATOM   330  C C   . THR A 1 44  ? 11.74016 -5.87980  31.59108  1.000 40.46954 ? 45  THR A C   1 
ATOM   331  O O   . THR A 1 44  ? 12.75784 -5.22430  31.35741  1.000 40.25184 ? 45  THR A O   1 
ATOM   332  C CB  . THR A 1 44  ? 11.69958 -8.15476  32.62475  1.000 44.55990 ? 45  THR A CB  1 
ATOM   333  O OG1 . THR A 1 44  ? 12.82676 -7.74092  33.40243  1.000 43.17633 ? 45  THR A OG1 1 
ATOM   334  C CG2 . THR A 1 44  ? 11.77550 -9.65858  32.37682  1.000 40.03372 ? 45  THR A CG2 1 
ATOM   335  N N   . SER A 1 45  ? 10.63266 -5.34114  32.11163  1.000 44.85758 ? 46  SER A N   1 
ATOM   336  C CA  . SER A 1 45  ? 10.60766 -3.92724  32.47600  1.000 44.45194 ? 46  SER A CA  1 
ATOM   337  C C   . SER A 1 45  ? 11.72260 -3.59084  33.44923  1.000 47.22156 ? 46  SER A C   1 
ATOM   338  O O   . SER A 1 45  ? 12.23669 -2.46590  33.44730  1.000 51.90935 ? 46  SER A O   1 
ATOM   339  C CB  . SER A 1 45  ? 9.25339  -3.55845  33.07980  1.000 50.65111 ? 46  SER A CB  1 
ATOM   340  O OG  . SER A 1 45  ? 8.32702  -3.18033  32.07336  1.000 55.75073 ? 46  SER A OG  1 
ATOM   341  N N   . GLU A 1 46  ? 12.12404 -4.56366  34.26668  1.000 46.46578 ? 47  GLU A N   1 
ATOM   342  C CA  . GLU A 1 46  ? 13.20926 -4.38171  35.21646  1.000 45.66595 ? 47  GLU A CA  1 
ATOM   343  C C   . GLU A 1 46  ? 14.56856 -4.28905  34.54059  1.000 45.77877 ? 47  GLU A C   1 
ATOM   344  O O   . GLU A 1 46  ? 15.54403 -3.91274  35.19611  1.000 46.15482 ? 47  GLU A O   1 
ATOM   345  C CB  . GLU A 1 46  ? 13.20598 -5.54453  36.20745  1.000 50.16282 ? 47  GLU A CB  1 
ATOM   346  C CG  . GLU A 1 46  ? 11.82372 -6.15204  36.40511  1.000 52.41835 ? 47  GLU A CG  1 
ATOM   347  C CD  . GLU A 1 46  ? 11.85431 -7.41842  37.23343  1.000 56.46890 ? 47  GLU A CD  1 
ATOM   348  O OE1 . GLU A 1 46  ? 11.27393 -8.43737  36.79033  1.000 59.06598 ? 47  GLU A OE1 1 
ATOM   349  O OE2 . GLU A 1 46  ? 12.46152 -7.39172  38.32582  1.000 57.83544 ? 47  GLU A OE2 1 
ATOM   350  N N   . ASP A 1 47  ? 14.66682 -4.63513  33.25494  1.000 44.76135 ? 48  ASP A N   1 
ATOM   351  C CA  . ASP A 1 47  ? 15.95548 -4.66579  32.57480  1.000 43.79829 ? 48  ASP A CA  1 
ATOM   352  C C   . ASP A 1 47  ? 15.99553 -3.83744  31.29700  1.000 40.10178 ? 48  ASP A C   1 
ATOM   353  O O   . ASP A 1 47  ? 17.01634 -3.86146  30.59923  1.000 39.71105 ? 48  ASP A O   1 
ATOM   354  C CB  . ASP A 1 47  ? 16.35578 -6.10783  32.25296  1.000 43.49933 ? 48  ASP A CB  1 
ATOM   355  C CG  . ASP A 1 47  ? 17.75801 -6.43237  32.72959  1.000 43.42209 ? 48  ASP A CG  1 
ATOM   356  O OD1 . ASP A 1 47  ? 18.46746 -5.50000  33.16830  1.000 44.84837 ? 48  ASP A OD1 1 
ATOM   357  O OD2 . ASP A 1 47  ? 18.15919 -7.60656  32.65893  1.000 46.56925 ? 48  ASP A OD2 1 
ATOM   358  N N   . MET A 1 48  ? 14.93660 -3.08665  30.98268  1.000 38.71302 ? 49  MET A N   1 
ATOM   359  C CA  . MET A 1 48  ? 14.86265 -2.43346  29.67686  1.000 32.62991 ? 49  MET A CA  1 
ATOM   360  C C   . MET A 1 48  ? 15.82433 -1.25641  29.54890  1.000 31.73141 ? 49  MET A C   1 
ATOM   361  O O   . MET A 1 48  ? 16.25161 -0.93745  28.43337  1.000 29.42501 ? 49  MET A O   1 
ATOM   362  C CB  . MET A 1 48  ? 13.42531 -1.98765  29.39846  1.000 36.96591 ? 49  MET A CB  1 
ATOM   363  C CG  . MET A 1 48  ? 12.53037 -3.14352  28.96462  1.000 41.92567 ? 49  MET A CG  1 
ATOM   364  S SD  . MET A 1 48  ? 10.86057 -2.69354  28.44714  1.000 51.86888 ? 49  MET A SD  1 
ATOM   365  C CE  . MET A 1 48  ? 10.27715 -4.24305  27.75160  1.000 46.74979 ? 49  MET A CE  1 
ATOM   366  N N   . LEU A 1 49  ? 16.19504 -0.60554  30.65928  1.000 27.89867 ? 50  LEU A N   1 
ATOM   367  C CA  . LEU A 1 49  ? 17.02172 0.59389   30.55129  1.000 28.24786 ? 50  LEU A CA  1 
ATOM   368  C C   . LEU A 1 49  ? 18.43433 0.27024   30.07424  1.000 27.95177 ? 50  LEU A C   1 
ATOM   369  O O   . LEU A 1 49  ? 18.99346 0.99328   29.23925  1.000 27.51538 ? 50  LEU A O   1 
ATOM   370  C CB  . LEU A 1 49  ? 17.06763 1.33208   31.89094  1.000 32.98129 ? 50  LEU A CB  1 
ATOM   371  C CG  . LEU A 1 49  ? 16.25468 2.62477   31.97720  1.000 34.63321 ? 50  LEU A CG  1 
ATOM   372  C CD1 . LEU A 1 49  ? 14.76318 2.34253   31.80285  1.000 34.25557 ? 50  LEU A CD1 1 
ATOM   373  C CD2 . LEU A 1 49  ? 16.53557 3.32946   33.29822  1.000 32.42815 ? 50  LEU A CD2 1 
ATOM   374  N N   . ASN A 1 50  ? 19.04427 -0.79369  30.60038  1.000 30.41748 ? 51  ASN A N   1 
ATOM   375  C CA  . ASN A 1 50  ? 20.37657 -1.21843  30.15859  1.000 32.60928 ? 51  ASN A CA  1 
ATOM   376  C C   . ASN A 1 50  ? 20.52356 -2.72646  30.30951  1.000 30.23367 ? 51  ASN A C   1 
ATOM   377  O O   . ASN A 1 50  ? 21.23672 -3.21772  31.19505  1.000 31.65276 ? 51  ASN A O   1 
ATOM   378  C CB  . ASN A 1 50  ? 21.46827 -0.48357  30.92732  1.000 33.94060 ? 51  ASN A CB  1 
ATOM   379  C CG  . ASN A 1 50  ? 22.80657 -0.60229  30.24882  1.000 36.26513 ? 51  ASN A CG  1 
ATOM   380  O OD1 . ASN A 1 50  ? 22.87531 -0.84025  29.03829  1.000 41.38967 ? 51  ASN A OD1 1 
ATOM   381  N ND2 . ASN A 1 50  ? 23.87630 -0.44858  31.01000  1.000 41.71334 ? 51  ASN A ND2 1 
ATOM   382  N N   . PRO A 1 51  ? 19.87548 -3.49822  29.44068  1.000 28.82385 ? 52  PRO A N   1 
ATOM   383  C CA  . PRO A 1 51  ? 19.91819 -4.96018  29.58035  1.000 27.74887 ? 52  PRO A CA  1 
ATOM   384  C C   . PRO A 1 51  ? 21.27765 -5.51544  29.19428  1.000 28.04856 ? 52  PRO A C   1 
ATOM   385  O O   . PRO A 1 51  ? 21.93087 -5.01614  28.27919  1.000 28.79551 ? 52  PRO A O   1 
ATOM   386  C CB  . PRO A 1 51  ? 18.83070 -5.43822  28.60664  1.000 30.44486 ? 52  PRO A CB  1 
ATOM   387  C CG  . PRO A 1 51  ? 18.81743 -4.37762  27.54690  1.000 31.60442 ? 52  PRO A CG  1 
ATOM   388  C CD  . PRO A 1 51  ? 19.15908 -3.07509  28.21864  1.000 30.21779 ? 52  PRO A CD  1 
ATOM   389  N N   . ASN A 1 52  ? 21.70067 -6.56994  29.89111  1.000 27.42389 ? 53  ASN A N   1 
ATOM   390  C CA  . ASN A 1 52  ? 22.87017 -7.35007  29.47746  1.000 25.89682 ? 53  ASN A CA  1 
ATOM   391  C C   . ASN A 1 52  ? 22.33212 -8.57781  28.74865  1.000 22.80780 ? 53  ASN A C   1 
ATOM   392  O O   . ASN A 1 52  ? 21.93901 -9.56544  29.37488  1.000 22.01813 ? 53  ASN A O   1 
ATOM   393  C CB  . ASN A 1 52  ? 23.74236 -7.72004  30.67461  1.000 24.36845 ? 53  ASN A CB  1 
ATOM   394  C CG  . ASN A 1 52  ? 25.05094 -8.37577  30.26614  1.000 31.10857 ? 53  ASN A CG  1 
ATOM   395  O OD1 . ASN A 1 52  ? 25.07031 -9.30590  29.45495  1.000 31.24701 ? 53  ASN A OD1 1 
ATOM   396  N ND2 . ASN A 1 52  ? 26.15264 -7.89830  30.83139  1.000 32.73395 ? 53  ASN A ND2 1 
ATOM   397  N N   . TYR A 1 53  ? 22.29103 -8.50407  27.41871  1.000 21.74589 ? 54  TYR A N   1 
ATOM   398  C CA  . TYR A 1 53  ? 21.63028 -9.55327  26.65168  1.000 22.83022 ? 54  TYR A CA  1 
ATOM   399  C C   . TYR A 1 53  ? 22.34930 -10.88950 26.76126  1.000 24.84134 ? 54  TYR A C   1 
ATOM   400  O O   . TYR A 1 53  ? 21.69532 -11.93919 26.75287  1.000 24.62896 ? 54  TYR A O   1 
ATOM   401  C CB  . TYR A 1 53  ? 21.51727 -9.12259  25.19602  1.000 21.01624 ? 54  TYR A CB  1 
ATOM   402  C CG  . TYR A 1 53  ? 20.39619 -8.13991  24.98754  1.000 21.51682 ? 54  TYR A CG  1 
ATOM   403  C CD1 . TYR A 1 53  ? 19.07396 -8.55073  25.09155  1.000 22.26997 ? 54  TYR A CD1 1 
ATOM   404  C CD2 . TYR A 1 53  ? 20.64861 -6.79807  24.70636  1.000 22.21362 ? 54  TYR A CD2 1 
ATOM   405  C CE1 . TYR A 1 53  ? 18.03198 -7.66758  24.89842  1.000 23.14345 ? 54  TYR A CE1 1 
ATOM   406  C CE2 . TYR A 1 53  ? 19.60009 -5.89477  24.50522  1.000 20.08049 ? 54  TYR A CE2 1 
ATOM   407  C CZ  . TYR A 1 53  ? 18.29529 -6.34307  24.60377  1.000 20.33497 ? 54  TYR A CZ  1 
ATOM   408  O OH  . TYR A 1 53  ? 17.24277 -5.47585  24.41349  1.000 19.98016 ? 54  TYR A OH  1 
ATOM   409  N N   . GLU A 1 54  ? 23.68359 -10.87991 26.83189  1.000 23.16056 ? 55  GLU A N   1 
ATOM   410  C CA  . GLU A 1 54  ? 24.41278 -12.13425 27.01033  1.000 28.50556 ? 55  GLU A CA  1 
ATOM   411  C C   . GLU A 1 54  ? 23.93109 -12.85437 28.26039  1.000 26.90100 ? 55  GLU A C   1 
ATOM   412  O O   . GLU A 1 54  ? 23.54890 -14.03165 28.20840  1.000 28.90709 ? 55  GLU A O   1 
ATOM   413  C CB  . GLU A 1 54  ? 25.91917 -11.87457 27.08271  1.000 30.25539 ? 55  GLU A CB  1 
ATOM   414  C CG  . GLU A 1 54  ? 26.51393 -11.20601 25.84274  1.000 34.82771 ? 55  GLU A CG  1 
ATOM   415  C CD  . GLU A 1 54  ? 26.23091 -9.70418  25.76631  1.000 40.50843 ? 55  GLU A CD  1 
ATOM   416  O OE1 . GLU A 1 54  ? 25.94861 -9.20179  24.65664  1.000 43.17366 ? 55  GLU A OE1 1 
ATOM   417  O OE2 . GLU A 1 54  ? 26.29307 -9.02183  26.81516  1.000 45.13850 ? 55  GLU A OE2 1 
ATOM   418  N N   . ASP A 1 55  ? 23.92200 -12.14520 29.39311  1.000 24.65014 ? 56  ASP A N   1 
ATOM   419  C CA  . ASP A 1 55  ? 23.45371 -12.71548 30.65105  1.000 28.99356 ? 56  ASP A CA  1 
ATOM   420  C C   . ASP A 1 55  ? 21.98575 -13.10803 30.57819  1.000 27.27276 ? 56  ASP A C   1 
ATOM   421  O O   . ASP A 1 55  ? 21.59516 -14.17527 31.06647  1.000 26.02588 ? 56  ASP A O   1 
ATOM   422  C CB  . ASP A 1 55  ? 23.66055 -11.71181 31.78628  1.000 28.07880 ? 56  ASP A CB  1 
ATOM   423  C CG  . ASP A 1 55  ? 25.12630 -11.46604 32.10123  1.000 34.03043 ? 56  ASP A CG  1 
ATOM   424  O OD1 . ASP A 1 55  ? 25.98800 -12.18888 31.56367  1.000 36.65014 ? 56  ASP A OD1 1 
ATOM   425  O OD2 . ASP A 1 55  ? 25.41944 -10.53694 32.88560  1.000 32.95609 ? 56  ASP A OD2 1 
ATOM   426  N N   . LEU A 1 56  ? 21.14817 -12.24518 29.99718  1.000 24.90971 ? 57  LEU A N   1 
ATOM   427  C CA  . LEU A 1 56  ? 19.72627 -12.55413 29.92653  1.000 25.21199 ? 57  LEU A CA  1 
ATOM   428  C C   . LEU A 1 56  ? 19.48786 -13.81698 29.11894  1.000 24.92605 ? 57  LEU A C   1 
ATOM   429  O O   . LEU A 1 56  ? 18.65909 -14.65655 29.49265  1.000 27.48411 ? 57  LEU A O   1 
ATOM   430  C CB  . LEU A 1 56  ? 18.95748 -11.38325 29.32111  1.000 24.02544 ? 57  LEU A CB  1 
ATOM   431  C CG  . LEU A 1 56  ? 18.92006 -10.14643 30.20694  1.000 29.42231 ? 57  LEU A CG  1 
ATOM   432  C CD1 . LEU A 1 56  ? 18.22509 -8.97599  29.50507  1.000 29.13716 ? 57  LEU A CD1 1 
ATOM   433  C CD2 . LEU A 1 56  ? 18.25122 -10.48423 31.52937  1.000 33.32084 ? 57  LEU A CD2 1 
ATOM   434  N N   . LEU A 1 57  ? 20.21651 -13.97434 28.01465  1.000 22.84539 ? 58  LEU A N   1 
ATOM   435  C CA  . LEU A 1 57  ? 20.05440 -15.16570 27.19168  1.000 23.15450 ? 58  LEU A CA  1 
ATOM   436  C C   . LEU A 1 57  ? 20.52990 -16.40852 27.92437  1.000 27.21153 ? 58  LEU A C   1 
ATOM   437  O O   . LEU A 1 57  ? 19.91446 -17.48004 27.81302  1.000 27.00044 ? 58  LEU A O   1 
ATOM   438  C CB  . LEU A 1 57  ? 20.81128 -14.99851 25.87474  1.000 23.65988 ? 58  LEU A CB  1 
ATOM   439  C CG  . LEU A 1 57  ? 20.39266 -16.06348 24.87530  1.000 24.54566 ? 58  LEU A CG  1 
ATOM   440  C CD1 . LEU A 1 57  ? 18.86136 -16.10358 24.81654  1.000 26.12045 ? 58  LEU A CD1 1 
ATOM   441  C CD2 . LEU A 1 57  ? 20.98213 -15.76751 23.51918  1.000 31.31362 ? 58  LEU A CD2 1 
ATOM   442  N N   . ILE A 1 58  ? 21.62635 -16.28400 28.67713  1.000 25.77419 ? 59  ILE A N   1 
ATOM   443  C CA  . ILE A 1 58  ? 22.11065 -17.40579 29.47926  1.000 27.06475 ? 59  ILE A CA  1 
ATOM   444  C C   . ILE A 1 58  ? 20.99498 -17.94013 30.36209  1.000 25.09605 ? 59  ILE A C   1 
ATOM   445  O O   . ILE A 1 58  ? 20.78641 -19.15464 30.45799  1.000 31.85946 ? 59  ILE A O   1 
ATOM   446  C CB  . ILE A 1 58  ? 23.33026 -16.97762 30.31709  1.000 26.35116 ? 59  ILE A CB  1 
ATOM   447  C CG1 . ILE A 1 58  ? 24.55325 -16.72883 29.43553  1.000 23.52893 ? 59  ILE A CG1 1 
ATOM   448  C CG2 . ILE A 1 58  ? 23.64546 -18.00425 31.39070  1.000 26.55788 ? 59  ILE A CG2 1 
ATOM   449  C CD1 . ILE A 1 58  ? 24.67334 -17.65724 28.31554  1.000 34.68629 ? 59  ILE A CD1 1 
ATOM   450  N N   . ARG A 1 59  ? 20.24271 -17.03856 30.99693  1.000 25.59774 ? 60  ARG A N   1 
ATOM   451  C CA  . ARG A 1 59  ? 19.22185 -17.43716 31.96000  1.000 34.05022 ? 60  ARG A CA  1 
ATOM   452  C C   . ARG A 1 59  ? 18.01749 -18.08642 31.29769  1.000 33.52715 ? 60  ARG A C   1 
ATOM   453  O O   . ARG A 1 59  ? 17.21371 -18.72328 31.98996  1.000 32.51114 ? 60  ARG A O   1 
ATOM   454  C CB  . ARG A 1 59  ? 18.77210 -16.22519 32.77881  1.000 37.44065 ? 60  ARG A CB  1 
ATOM   455  C CG  . ARG A 1 59  ? 19.68171 -15.88447 33.95743  1.000 42.88098 ? 60  ARG A CG  1 
ATOM   456  C CD  . ARG A 1 59  ? 19.26082 -16.61647 35.23963  1.000 53.88632 ? 60  ARG A CD  1 
ATOM   457  N NE  . ARG A 1 59  ? 17.91918 -16.23730 35.69313  1.000 58.49186 ? 60  ARG A NE  1 
ATOM   458  C CZ  . ARG A 1 59  ? 16.93600 -17.10041 35.94621  1.000 59.04471 ? 60  ARG A CZ  1 
ATOM   459  N NH1 . ARG A 1 59  ? 15.75062 -16.65994 36.35303  1.000 58.74758 ? 60  ARG A NH1 1 
ATOM   460  N NH2 . ARG A 1 59  ? 17.13428 -18.40515 35.79470  1.000 57.46419 ? 60  ARG A NH2 1 
ATOM   461  N N   . LYS A 1 60  ? 17.87142 -17.93696 29.98411  1.000 31.83373 ? 61  LYS A N   1 
ATOM   462  C CA  . LYS A 1 60  ? 16.73851 -18.51788 29.28675  1.000 31.82949 ? 61  LYS A CA  1 
ATOM   463  C C   . LYS A 1 60  ? 17.01646 -19.96333 28.91209  1.000 32.34860 ? 61  LYS A C   1 
ATOM   464  O O   . LYS A 1 60  ? 18.15928 -20.36471 28.66425  1.000 29.41195 ? 61  LYS A O   1 
ATOM   465  C CB  . LYS A 1 60  ? 16.40475 -17.71499 28.02568  1.000 28.58267 ? 61  LYS A CB  1 
ATOM   466  C CG  . LYS A 1 60  ? 15.74223 -16.37844 28.31227  1.000 28.20897 ? 61  LYS A CG  1 
ATOM   467  C CD  . LYS A 1 60  ? 14.52407 -16.55103 29.18504  1.000 33.03060 ? 61  LYS A CD  1 
ATOM   468  C CE  . LYS A 1 60  ? 13.85932 -15.21073 29.41560  1.000 35.09047 ? 61  LYS A CE  1 
ATOM   469  N NZ  . LYS A 1 60  ? 14.89607 -14.17452 29.69095  1.000 41.12277 ? 61  LYS A NZ  1 
ATOM   470  N N   . SER A 1 61  ? 15.94490 -20.74576 28.88368  1.000 28.89281 ? 62  SER A N   1 
ATOM   471  C CA  . SER A 1 61  ? 15.95913 -22.10404 28.38493  1.000 32.19724 ? 62  SER A CA  1 
ATOM   472  C C   . SER A 1 61  ? 15.03079 -22.15626 27.18489  1.000 30.57901 ? 62  SER A C   1 
ATOM   473  O O   . SER A 1 61  ? 14.21267 -21.25329 26.98899  1.000 30.55277 ? 62  SER A O   1 
ATOM   474  C CB  . SER A 1 61  ? 15.49991 -23.09679 29.45316  1.000 33.69401 ? 62  SER A CB  1 
ATOM   475  O OG  . SER A 1 61  ? 16.44672 -23.20360 30.50460  1.000 36.15558 ? 62  SER A OG  1 
ATOM   476  N N   . ASN A 1 62  ? 15.16674 -23.22701 26.39406  1.000 27.72180 ? 63  ASN A N   1 
ATOM   477  C CA  . ASN A 1 62  ? 14.32187 -23.41547 25.21673  1.000 30.10614 ? 63  ASN A CA  1 
ATOM   478  C C   . ASN A 1 62  ? 12.84582 -23.23360 25.54848  1.000 35.85941 ? 63  ASN A C   1 
ATOM   479  O O   . ASN A 1 62  ? 12.10255 -22.57934 24.79828  1.000 33.92408 ? 63  ASN A O   1 
ATOM   480  C CB  . ASN A 1 62  ? 14.56504 -24.80857 24.62315  1.000 28.55686 ? 63  ASN A CB  1 
ATOM   481  C CG  . ASN A 1 62  ? 15.86806 -24.89431 23.84862  1.000 30.53280 ? 63  ASN A CG  1 
ATOM   482  O OD1 . ASN A 1 62  ? 16.44009 -23.87243 23.46357  1.000 31.39255 ? 63  ASN A OD1 1 
ATOM   483  N ND2 . ASN A 1 62  ? 16.33956 -26.11122 23.60766  1.000 29.03670 ? 63  ASN A ND2 1 
ATOM   484  N N   . HIS A 1 63  ? 12.40296 -23.79453 26.67502  1.000 31.02438 ? 64  HIS A N   1 
ATOM   485  C CA  . HIS A 1 63  ? 10.98718 -23.76813 27.02236  1.000 31.84377 ? 64  HIS A CA  1 
ATOM   486  C C   . HIS A 1 63  ? 10.50445 -22.40787 27.50621  1.000 33.95491 ? 64  HIS A C   1 
ATOM   487  O O   . HIS A 1 63  ? 9.30948  -22.27193 27.78861  1.000 35.33848 ? 64  HIS A O   1 
ATOM   488  C CB  . HIS A 1 63  ? 10.69536 -24.81830 28.09444  1.000 35.16104 ? 64  HIS A CB  1 
ATOM   489  C CG  . HIS A 1 63  ? 11.55990 -24.68701 29.30498  1.000 36.51229 ? 64  HIS A CG  1 
ATOM   490  N ND1 . HIS A 1 63  ? 12.69495 -25.44655 29.49372  1.000 35.98952 ? 64  HIS A ND1 1 
ATOM   491  C CD2 . HIS A 1 63  ? 11.46845 -23.86788 30.37900  1.000 37.61333 ? 64  HIS A CD2 1 
ATOM   492  C CE1 . HIS A 1 63  ? 13.25940 -25.10699 30.63857  1.000 38.16507 ? 64  HIS A CE1 1 
ATOM   493  N NE2 . HIS A 1 63  ? 12.54073 -24.14465 31.19026  1.000 33.92103 ? 64  HIS A NE2 1 
ATOM   494  N N   . ASN A 1 64  ? 11.37928 -21.40834 27.63536  1.000 29.87061 ? 65  ASN A N   1 
ATOM   495  C CA  . ASN A 1 64  ? 10.91677 -20.05707 27.91061  1.000 32.78231 ? 65  ASN A CA  1 
ATOM   496  C C   . ASN A 1 64  ? 10.42049 -19.34678 26.65922  1.000 31.21630 ? 65  ASN A C   1 
ATOM   497  O O   . ASN A 1 64  ? 9.82329  -18.27230 26.77421  1.000 31.44552 ? 65  ASN A O   1 
ATOM   498  C CB  . ASN A 1 64  ? 12.03095 -19.23346 28.55384  1.000 28.06520 ? 65  ASN A CB  1 
ATOM   499  C CG  . ASN A 1 64  ? 12.38336 -19.72304 29.95002  1.000 35.59477 ? 65  ASN A CG  1 
ATOM   500  O OD1 . ASN A 1 64  ? 13.47044 -20.24447 30.17983  1.000 32.77045 ? 65  ASN A OD1 1 
ATOM   501  N ND2 . ASN A 1 64  ? 11.45243 -19.56056 30.88778  1.000 35.34091 ? 65  ASN A ND2 1 
ATOM   502  N N   . PHE A 1 65  ? 10.63814 -19.92668 25.48663  1.000 30.91493 ? 66  PHE A N   1 
ATOM   503  C CA  . PHE A 1 65  ? 10.28506 -19.32401 24.20436  1.000 29.97820 ? 66  PHE A CA  1 
ATOM   504  C C   . PHE A 1 65  ? 9.07888  -20.05523 23.62758  1.000 32.45902 ? 66  PHE A C   1 
ATOM   505  O O   . PHE A 1 65  ? 9.21065  -21.18415 23.14480  1.000 32.81456 ? 66  PHE A O   1 
ATOM   506  C CB  . PHE A 1 65  ? 11.46189 -19.40680 23.23803  1.000 31.38036 ? 66  PHE A CB  1 
ATOM   507  C CG  . PHE A 1 65  ? 12.65998 -18.62838 23.67724  1.000 27.22650 ? 66  PHE A CG  1 
ATOM   508  C CD1 . PHE A 1 65  ? 12.64897 -17.24299 23.64688  1.000 31.54082 ? 66  PHE A CD1 1 
ATOM   509  C CD2 . PHE A 1 65  ? 13.80357 -19.28077 24.11113  1.000 29.00189 ? 66  PHE A CD2 1 
ATOM   510  C CE1 . PHE A 1 65  ? 13.75371 -16.52115 24.05410  1.000 28.14348 ? 66  PHE A CE1 1 
ATOM   511  C CE2 . PHE A 1 65  ? 14.91144 -18.56312 24.51249  1.000 31.88701 ? 66  PHE A CE2 1 
ATOM   512  C CZ  . PHE A 1 65  ? 14.88607 -17.18041 24.48084  1.000 26.46220 ? 66  PHE A CZ  1 
ATOM   513  N N   . LEU A 1 66  ? 7.91378  -19.41041 23.66058  1.000 32.31002 ? 67  LEU A N   1 
ATOM   514  C CA  . LEU A 1 66  ? 6.69324  -19.97423 23.10071  1.000 33.34367 ? 67  LEU A CA  1 
ATOM   515  C C   . LEU A 1 66  ? 6.54024  -19.44140 21.68436  1.000 31.65889 ? 67  LEU A C   1 
ATOM   516  O O   . LEU A 1 66  ? 6.41772  -18.22717 21.49263  1.000 32.23232 ? 67  LEU A O   1 
ATOM   517  C CB  . LEU A 1 66  ? 5.48011  -19.59309 23.94626  1.000 37.67065 ? 67  LEU A CB  1 
ATOM   518  C CG  . LEU A 1 66  ? 5.59150  -19.92273 25.43378  1.000 42.53886 ? 67  LEU A CG  1 
ATOM   519  C CD1 . LEU A 1 66  ? 4.25475  -19.74893 26.13608  1.000 47.36397 ? 67  LEU A CD1 1 
ATOM   520  C CD2 . LEU A 1 66  ? 6.11643  -21.33605 25.59433  1.000 46.06997 ? 67  LEU A CD2 1 
ATOM   521  N N   . VAL A 1 67  ? 6.57118  -20.33895 20.70395  1.000 30.58478 ? 68  VAL A N   1 
ATOM   522  C CA  . VAL A 1 67  ? 6.43470  -19.98263 19.29631  1.000 29.14901 ? 68  VAL A CA  1 
ATOM   523  C C   . VAL A 1 67  ? 5.18763  -20.65770 18.74832  1.000 32.21415 ? 68  VAL A C   1 
ATOM   524  O O   . VAL A 1 67  ? 5.02000  -21.87328 18.89726  1.000 29.65613 ? 68  VAL A O   1 
ATOM   525  C CB  . VAL A 1 67  ? 7.67848  -20.39106 18.48814  1.000 28.17490 ? 68  VAL A CB  1 
ATOM   526  C CG1 . VAL A 1 67  ? 7.55778  -19.90240 17.03638  1.000 30.00367 ? 68  VAL A CG1 1 
ATOM   527  C CG2 . VAL A 1 67  ? 8.92055  -19.82134 19.14457  1.000 27.34585 ? 68  VAL A CG2 1 
ATOM   528  N N   . GLN A 1 68  ? 4.32707  -19.87830 18.09678  1.000 31.48723 ? 69  GLN A N   1 
ATOM   529  C CA  . GLN A 1 68  ? 3.11081  -20.41924 17.51155  1.000 33.43153 ? 69  GLN A CA  1 
ATOM   530  C C   . GLN A 1 68  ? 3.01534  -19.99159 16.05821  1.000 32.01421 ? 69  GLN A C   1 
ATOM   531  O O   . GLN A 1 68  ? 3.22568  -18.81771 15.73874  1.000 29.01263 ? 69  GLN A O   1 
ATOM   532  C CB  . GLN A 1 68  ? 1.87522  -19.96891 18.29487  1.000 36.73688 ? 69  GLN A CB  1 
ATOM   533  C CG  . GLN A 1 68  ? 1.40761  -21.01955 19.29277  1.000 48.17419 ? 69  GLN A CG  1 
ATOM   534  C CD  . GLN A 1 68  ? 0.12274  -20.64145 19.99637  1.000 54.32584 ? 69  GLN A CD  1 
ATOM   535  O OE1 . GLN A 1 68  ? 0.12843  -19.85778 20.94818  1.000 59.01047 ? 69  GLN A OE1 1 
ATOM   536  N NE2 . GLN A 1 68  ? -0.98922 -21.20689 19.53956  1.000 57.13913 ? 69  GLN A NE2 1 
ATOM   537  N N   . ALA A 1 69  ? 2.73203  -20.95062 15.18323  1.000 37.61473 ? 70  ALA A N   1 
ATOM   538  C CA  . ALA A 1 69  ? 2.45424  -20.69778 13.77347  1.000 35.64705 ? 70  ALA A CA  1 
ATOM   539  C C   . ALA A 1 69  ? 0.96464  -20.93326 13.56671  1.000 39.82094 ? 70  ALA A C   1 
ATOM   540  O O   . ALA A 1 69  ? 0.50537  -22.07893 13.57052  1.000 43.91937 ? 70  ALA A O   1 
ATOM   541  C CB  . ALA A 1 69  ? 3.29582  -21.59627 12.86955  1.000 33.55784 ? 70  ALA A CB  1 
ATOM   542  N N   . GLY A 1 70  ? 0.21276  -19.85331 13.39846  1.000 40.29162 ? 71  GLY A N   1 
ATOM   543  C CA  . GLY A 1 70  ? -1.22995 -19.95507 13.37607  1.000 47.64472 ? 71  GLY A CA  1 
ATOM   544  C C   . GLY A 1 70  ? -1.75592 -20.33862 14.74231  1.000 53.61529 ? 71  GLY A C   1 
ATOM   545  O O   . GLY A 1 70  ? -1.73851 -19.52382 15.67217  1.000 57.52003 ? 71  GLY A O   1 
ATOM   546  N N   . ASN A 1 71  ? -2.22664 -21.57884 14.88019  1.000 52.73349 ? 72  ASN A N   1 
ATOM   547  C CA  . ASN A 1 71  ? -2.59919 -22.13077 16.17823  1.000 56.06332 ? 72  ASN A CA  1 
ATOM   548  C C   . ASN A 1 71  ? -1.75779 -23.35616 16.51476  1.000 55.64750 ? 72  ASN A C   1 
ATOM   549  O O   . ASN A 1 71  ? -2.16634 -24.19028 17.33052  1.000 58.65271 ? 72  ASN A O   1 
ATOM   550  C CB  . ASN A 1 71  ? -4.09280 -22.46789 16.21919  1.000 58.91488 ? 72  ASN A CB  1 
ATOM   551  C CG  . ASN A 1 71  ? -4.53784 -23.30104 15.03226  1.000 60.78053 ? 72  ASN A CG  1 
ATOM   552  O OD1 . ASN A 1 71  ? -3.74360 -24.03416 14.43677  1.000 60.51968 ? 72  ASN A OD1 1 
ATOM   553  N ND2 . ASN A 1 71  ? -5.81643 -23.19521 14.68272  1.000 61.37389 ? 72  ASN A ND2 1 
ATOM   554  N N   . VAL A 1 72  ? -0.58439 -23.46992 15.89968  1.000 51.10846 ? 73  VAL A N   1 
ATOM   555  C CA  . VAL A 1 72  ? 0.29343  -24.62590 16.02825  1.000 47.77757 ? 73  VAL A CA  1 
ATOM   556  C C   . VAL A 1 72  ? 1.52044  -24.20979 16.82523  1.000 46.82597 ? 73  VAL A C   1 
ATOM   557  O O   . VAL A 1 72  ? 2.16343  -23.20719 16.49857  1.000 43.24656 ? 73  VAL A O   1 
ATOM   558  C CB  . VAL A 1 72  ? 0.69418  -25.15547 14.64293  1.000 47.66590 ? 73  VAL A CB  1 
ATOM   559  C CG1 . VAL A 1 72  ? 1.96872  -25.98074 14.71683  1.000 46.14481 ? 73  VAL A CG1 1 
ATOM   560  C CG2 . VAL A 1 72  ? -0.44039 -25.92693 14.06150  1.000 52.09317 ? 73  VAL A CG2 1 
ATOM   561  N N   . GLN A 1 73  ? 1.85960  -24.98661 17.85244  1.000 43.59016 ? 74  GLN A N   1 
ATOM   562  C CA  . GLN A 1 73  ? 2.95028  -24.64396 18.75997  1.000 43.12360 ? 74  GLN A CA  1 
ATOM   563  C C   . GLN A 1 73  ? 4.22672  -25.35467 18.31900  1.000 41.89939 ? 74  GLN A C   1 
ATOM   564  O O   . GLN A 1 73  ? 4.30404  -26.58678 18.35800  1.000 42.42766 ? 74  GLN A O   1 
ATOM   565  C CB  . GLN A 1 73  ? 2.57389  -25.00514 20.19279  1.000 46.12458 ? 74  GLN A CB  1 
ATOM   566  C CG  . GLN A 1 73  ? 1.19697  -24.50578 20.56147  1.000 51.49192 ? 74  GLN A CG  1 
ATOM   567  C CD  . GLN A 1 73  ? 1.14362  -23.93033 21.95296  1.000 58.63419 ? 74  GLN A CD  1 
ATOM   568  O OE1 . GLN A 1 73  ? 1.90517  -24.33576 22.83156  1.000 57.99261 ? 74  GLN A OE1 1 
ATOM   569  N NE2 . GLN A 1 73  ? 0.25427  -22.95943 22.16099  1.000 61.85867 ? 74  GLN A NE2 1 
ATOM   570  N N   . LEU A 1 74  ? 5.22537  -24.57412 17.90213  1.000 33.99947 ? 75  LEU A N   1 
ATOM   571  C CA  . LEU A 1 74  ? 6.50749  -25.10473 17.45748  1.000 35.13346 ? 75  LEU A CA  1 
ATOM   572  C C   . LEU A 1 74  ? 7.45195  -25.20854 18.64145  1.000 39.60404 ? 75  LEU A C   1 
ATOM   573  O O   . LEU A 1 74  ? 7.62885  -24.23868 19.38598  1.000 37.38338 ? 75  LEU A O   1 
ATOM   574  C CB  . LEU A 1 74  ? 7.14915  -24.21047 16.39697  1.000 35.06308 ? 75  LEU A CB  1 
ATOM   575  C CG  . LEU A 1 74  ? 6.32720  -23.74433 15.20081  1.000 36.98332 ? 75  LEU A CG  1 
ATOM   576  C CD1 . LEU A 1 74  ? 7.20779  -22.91004 14.26855  1.000 30.78591 ? 75  LEU A CD1 1 
ATOM   577  C CD2 . LEU A 1 74  ? 5.75338  -24.93820 14.48330  1.000 38.33430 ? 75  LEU A CD2 1 
ATOM   578  N N   . ARG A 1 75  ? 8.08479  -26.36571 18.79124  1.000 35.57117 ? 76  ARG A N   1 
ATOM   579  C CA  . ARG A 1 75  ? 9.00016  -26.57251 19.90274  1.000 35.12595 ? 76  ARG A CA  1 
ATOM   580  C C   . ARG A 1 75  ? 10.36080 -25.98015 19.56809  1.000 32.55509 ? 76  ARG A C   1 
ATOM   581  O O   . ARG A 1 75  ? 10.99262 -26.38068 18.58184  1.000 30.22927 ? 76  ARG A O   1 
ATOM   582  C CB  . ARG A 1 75  ? 9.13164  -28.06007 20.22471  1.000 37.68673 ? 76  ARG A CB  1 
ATOM   583  C CG  . ARG A 1 75  ? 10.10602 -28.33861 21.35439  1.000 36.41958 ? 76  ARG A CG  1 
ATOM   584  C CD  . ARG A 1 75  ? 10.45892 -29.81698 21.40264  1.000 38.14118 ? 76  ARG A CD  1 
ATOM   585  N NE  . ARG A 1 75  ? 9.38434  -30.58655 22.01718  1.000 42.56751 ? 76  ARG A NE  1 
ATOM   586  C CZ  . ARG A 1 75  ? 9.40694  -31.90611 22.16174  1.000 38.59969 ? 76  ARG A CZ  1 
ATOM   587  N NH1 . ARG A 1 75  ? 10.44772 -32.60268 21.72551  1.000 35.93408 ? 76  ARG A NH1 1 
ATOM   588  N NH2 . ARG A 1 75  ? 8.38706  -32.52128 22.73491  1.000 39.23537 ? 76  ARG A NH2 1 
ATOM   589  N N   . VAL A 1 76  ? 10.82100 -25.04471 20.39673  1.000 32.79011 ? 77  VAL A N   1 
ATOM   590  C CA  . VAL A 1 76  ? 12.15105 -24.49040 20.20159  1.000 28.85785 ? 77  VAL A CA  1 
ATOM   591  C C   . VAL A 1 76  ? 13.18153 -25.53986 20.59352  1.000 30.87331 ? 77  VAL A C   1 
ATOM   592  O O   . VAL A 1 76  ? 13.14659 -26.07578 21.70778  1.000 33.51216 ? 77  VAL A O   1 
ATOM   593  C CB  . VAL A 1 76  ? 12.33035 -23.19196 20.99276  1.000 31.36167 ? 77  VAL A CB  1 
ATOM   594  C CG1 . VAL A 1 76  ? 13.79448 -22.75093 20.94562  1.000 27.60039 ? 77  VAL A CG1 1 
ATOM   595  C CG2 . VAL A 1 76  ? 11.41733 -22.11193 20.40204  1.000 30.25522 ? 77  VAL A CG2 1 
ATOM   596  N N   . ILE A 1 77  ? 14.08937 -25.84500 19.66125  1.000 30.98623 ? 78  ILE A N   1 
ATOM   597  C CA  . ILE A 1 77  ? 15.14535 -26.83838 19.84147  1.000 35.02440 ? 78  ILE A CA  1 
ATOM   598  C C   . ILE A 1 77  ? 16.43350 -26.22625 20.38769  1.000 34.90474 ? 78  ILE A C   1 
ATOM   599  O O   . ILE A 1 77  ? 17.23198 -26.93998 21.01732  1.000 36.24256 ? 78  ILE A O   1 
ATOM   600  C CB  . ILE A 1 77  ? 15.40318 -27.55736 18.49281  1.000 35.07092 ? 78  ILE A CB  1 
ATOM   601  C CG1 . ILE A 1 77  ? 14.23946 -28.49567 18.15339  1.000 41.68870 ? 78  ILE A CG1 1 
ATOM   602  C CG2 . ILE A 1 77  ? 16.73870 -28.28700 18.45085  1.000 43.06555 ? 78  ILE A CG2 1 
ATOM   603  C CD1 . ILE A 1 77  ? 13.60000 -29.16418 19.35879  1.000 35.43174 ? 78  ILE A CD1 1 
ATOM   604  N N   . GLY A 1 78  ? 16.64362 -24.93161 20.18506  1.000 31.25137 ? 79  GLY A N   1 
ATOM   605  C CA  . GLY A 1 78  ? 17.86486 -24.26619 20.57758  1.000 28.46567 ? 79  GLY A CA  1 
ATOM   606  C C   . GLY A 1 78  ? 17.71068 -22.78344 20.33915  1.000 28.12035 ? 79  GLY A C   1 
ATOM   607  O O   . GLY A 1 78  ? 16.80036 -22.34675 19.62632  1.000 27.58522 ? 79  GLY A O   1 
ATOM   608  N N   . HIS A 1 79  ? 18.59751 -22.00925 20.96228  1.000 29.06981 ? 80  HIS A N   1 
ATOM   609  C CA  . HIS A 1 79  ? 18.48823 -20.55788 20.88438  1.000 27.66164 ? 80  HIS A CA  1 
ATOM   610  C C   . HIS A 1 79  ? 19.87305 -19.93428 20.91215  1.000 31.17513 ? 80  HIS A C   1 
ATOM   611  O O   . HIS A 1 79  ? 20.75830 -20.37807 21.65356  1.000 29.87077 ? 80  HIS A O   1 
ATOM   612  C CB  . HIS A 1 79  ? 17.61496 -19.98748 22.01431  1.000 26.00010 ? 80  HIS A CB  1 
ATOM   613  C CG  . HIS A 1 79  ? 18.12108 -20.28779 23.38860  1.000 30.95452 ? 80  HIS A CG  1 
ATOM   614  N ND1 . HIS A 1 79  ? 17.84367 -21.47071 24.03966  1.000 28.54242 ? 80  HIS A ND1 1 
ATOM   615  C CD2 . HIS A 1 79  ? 18.88010 -19.55739 24.23918  1.000 30.35767 ? 80  HIS A CD2 1 
ATOM   616  C CE1 . HIS A 1 79  ? 18.41825 -21.45895 25.23028  1.000 33.37967 ? 80  HIS A CE1 1 
ATOM   617  N NE2 . HIS A 1 79  ? 19.05160 -20.30856 25.37691  1.000 31.94220 ? 80  HIS A NE2 1 
ATOM   618  N N   . SER A 1 80  ? 20.05550 -18.91887 20.07246  1.000 25.67916 ? 81  SER A N   1 
ATOM   619  C CA  . SER A 1 80  ? 21.31965 -18.21184 19.98706  1.000 24.85938 ? 81  SER A CA  1 
ATOM   620  C C   . SER A 1 80  ? 21.03362 -16.78474 19.55823  1.000 26.55063 ? 81  SER A C   1 
ATOM   621  O O   . SER A 1 80  ? 19.94526 -16.46059 19.08306  1.000 24.30220 ? 81  SER A O   1 
ATOM   622  C CB  . SER A 1 80  ? 22.28990 -18.87849 19.00918  1.000 25.10438 ? 81  SER A CB  1 
ATOM   623  O OG  . SER A 1 80  ? 21.77325 -18.86485 17.69732  1.000 27.79826 ? 81  SER A OG  1 
ATOM   624  N N   . MET A 1 81  ? 22.03922 -15.94065 19.72024  1.000 24.70394 ? 82  MET A N   1 
ATOM   625  C CA  . MET A 1 81  ? 21.92550 -14.52548 19.43443  1.000 23.27652 ? 82  MET A CA  1 
ATOM   626  C C   . MET A 1 81  ? 22.94002 -14.17595 18.36190  1.000 25.55011 ? 82  MET A C   1 
ATOM   627  O O   . MET A 1 81  ? 24.12630 -14.47135 18.52294  1.000 24.28805 ? 82  MET A O   1 
ATOM   628  C CB  . MET A 1 81  ? 22.17986 -13.73639 20.71393  1.000 28.22836 ? 82  MET A CB  1 
ATOM   629  C CG  . MET A 1 81  ? 21.91075 -12.27969 20.62596  1.000 31.11131 ? 82  MET A CG  1 
ATOM   630  S SD  . MET A 1 81  ? 21.98886 -11.65355 22.29202  1.000 29.08267 ? 82  MET A SD  1 
ATOM   631  C CE  . MET A 1 81  ? 23.65082 -12.11500 22.78705  1.000 25.81085 ? 82  MET A CE  1 
ATOM   632  N N   . GLN A 1 82  ? 22.47839 -13.54640 17.27445  1.000 23.39330 ? 83  GLN A N   1 
ATOM   633  C CA  . GLN A 1 82  ? 23.35185 -12.98806 16.24450  1.000 20.49312 ? 83  GLN A CA  1 
ATOM   634  C C   . GLN A 1 82  ? 23.12944 -11.47857 16.23849  1.000 19.71820 ? 83  GLN A C   1 
ATOM   635  O O   . GLN A 1 82  ? 22.07794 -11.00579 15.78908  1.000 20.45033 ? 83  GLN A O   1 
ATOM   636  C CB  . GLN A 1 82  ? 23.05322 -13.60457 14.87433  1.000 25.53965 ? 83  GLN A CB  1 
ATOM   637  C CG  . GLN A 1 82  ? 24.03388 -13.22479 13.76350  1.000 27.51590 ? 83  GLN A CG  1 
ATOM   638  C CD  . GLN A 1 82  ? 23.63746 -13.79770 12.40685  1.000 29.84877 ? 83  GLN A CD  1 
ATOM   639  O OE1 . GLN A 1 82  ? 22.60176 -14.46327 12.27349  1.000 33.58825 ? 83  GLN A OE1 1 
ATOM   640  N NE2 . GLN A 1 82  ? 24.45894 -13.54165 11.39061  1.000 31.77932 ? 83  GLN A NE2 1 
ATOM   641  N N   . ASN A 1 83  ? 24.10464 -10.73033 16.76121  1.000 17.81544 ? 84  ASN A N   1 
ATOM   642  C CA  . ASN A 1 83  ? 23.95960 -9.29894  16.96119  1.000 21.64876 ? 84  ASN A CA  1 
ATOM   643  C C   . ASN A 1 83  ? 22.65609 -9.05988  17.71938  1.000 16.91747 ? 84  ASN A C   1 
ATOM   644  O O   . ASN A 1 83  ? 22.49727 -9.58974  18.81757  1.000 17.46990 ? 84  ASN A O   1 
ATOM   645  C CB  . ASN A 1 83  ? 24.04324 -8.59388  15.60577  1.000 19.05072 ? 84  ASN A CB  1 
ATOM   646  C CG  . ASN A 1 83  ? 25.33178 -8.95140  14.86367  1.000 22.29998 ? 84  ASN A CG  1 
ATOM   647  O OD1 . ASN A 1 83  ? 26.43352 -8.69507  15.36044  1.000 27.47834 ? 84  ASN A OD1 1 
ATOM   648  N ND2 . ASN A 1 83  ? 25.20286 -9.59834  13.71677  1.000 22.40438 ? 84  ASN A ND2 1 
ATOM   649  N N   . CYS A 1 84  ? 21.70516 -8.31802  17.14919  1.000 16.03363 ? 85  CYS A N   1 
ATOM   650  C CA  . CYS A 1 84  ? 20.47970 -7.97116  17.86516  1.000 19.22726 ? 85  CYS A CA  1 
ATOM   651  C C   . CYS A 1 84  ? 19.28421 -8.84723  17.49098  1.000 18.86953 ? 85  CYS A C   1 
ATOM   652  O O   . CYS A 1 84  ? 18.14817 -8.52416  17.86032  1.000 17.84757 ? 85  CYS A O   1 
ATOM   653  C CB  . CYS A 1 84  ? 20.14146 -6.49568  17.64640  1.000 17.70668 ? 85  CYS A CB  1 
ATOM   654  S SG  . CYS A 1 84  ? 21.40037 -5.36536  18.28741  1.000 20.84046 ? 85  CYS A SG  1 
ATOM   655  N N   . VAL A 1 85  ? 19.49571 -9.96865  16.81648  1.000 17.51211 ? 86  VAL A N   1 
ATOM   656  C CA  . VAL A 1 85  ? 18.39256 -10.88608 16.57428  1.000 18.05325 ? 86  VAL A CA  1 
ATOM   657  C C   . VAL A 1 85  ? 18.64521 -12.21343 17.26803  1.000 20.60953 ? 86  VAL A C   1 
ATOM   658  O O   . VAL A 1 85  ? 19.78035 -12.69508 17.36516  1.000 21.11474 ? 86  VAL A O   1 
ATOM   659  C CB  . VAL A 1 85  ? 18.09600 -11.11199 15.07958  1.000 25.37898 ? 86  VAL A CB  1 
ATOM   660  C CG1 . VAL A 1 85  ? 17.55502 -9.80591  14.44991  1.000 19.18112 ? 86  VAL A CG1 1 
ATOM   661  C CG2 . VAL A 1 85  ? 19.31606 -11.65721 14.35619  1.000 26.13551 ? 86  VAL A CG2 1 
ATOM   662  N N   . LEU A 1 86  ? 17.55747 -12.79043 17.74814  1.000 19.27298 ? 87  LEU A N   1 
ATOM   663  C CA  . LEU A 1 86  ? 17.53570 -14.12083 18.31825  1.000 22.25125 ? 87  LEU A CA  1 
ATOM   664  C C   . LEU A 1 86  ? 17.15807 -15.11021 17.21822  1.000 25.96063 ? 87  LEU A C   1 
ATOM   665  O O   . LEU A 1 86  ? 16.24273 -14.85087 16.42747  1.000 21.01432 ? 87  LEU A O   1 
ATOM   666  C CB  . LEU A 1 86  ? 16.52779 -14.13083 19.46773  1.000 23.30953 ? 87  LEU A CB  1 
ATOM   667  C CG  . LEU A 1 86  ? 16.27042 -15.31853 20.37194  1.000 29.24070 ? 87  LEU A CG  1 
ATOM   668  C CD1 . LEU A 1 86  ? 17.48133 -15.61845 21.21210  1.000 28.90620 ? 87  LEU A CD1 1 
ATOM   669  C CD2 . LEU A 1 86  ? 15.08001 -14.95619 21.23449  1.000 31.40504 ? 87  LEU A CD2 1 
ATOM   670  N N   . LYS A 1 87  ? 17.89914 -16.21022 17.13767  1.000 20.60314 ? 88  LYS A N   1 
ATOM   671  C CA  . LYS A 1 87  ? 17.62189 -17.29862 16.21397  1.000 25.54557 ? 88  LYS A CA  1 
ATOM   672  C C   . LYS A 1 87  ? 17.14268 -18.47262 17.05270  1.000 27.96446 ? 88  LYS A C   1 
ATOM   673  O O   . LYS A 1 87  ? 17.91845 -19.03578 17.83081  1.000 26.27019 ? 88  LYS A O   1 
ATOM   674  C CB  . LYS A 1 87  ? 18.86066 -17.65652 15.40021  1.000 25.90238 ? 88  LYS A CB  1 
ATOM   675  C CG  . LYS A 1 87  ? 19.41112 -16.47830 14.62310  1.000 26.05778 ? 88  LYS A CG  1 
ATOM   676  C CD  . LYS A 1 87  ? 20.28704 -16.92173 13.46907  1.000 28.81802 ? 88  LYS A CD  1 
ATOM   677  C CE  . LYS A 1 87  ? 21.69544 -17.19729 13.89537  1.000 33.50601 ? 88  LYS A CE  1 
ATOM   678  N NZ  . LYS A 1 87  ? 22.58196 -17.23214 12.69444  1.000 37.65351 ? 88  LYS A NZ  1 
ATOM   679  N N   . LEU A 1 88  ? 15.86357 -18.81330 16.91777  1.000 22.09381 ? 89  LEU A N   1 
ATOM   680  C CA  . LEU A 1 88  ? 15.25355 -19.90760 17.66290  1.000 24.68735 ? 89  LEU A CA  1 
ATOM   681  C C   . LEU A 1 88  ? 15.19168 -21.12033 16.74069  1.000 25.86899 ? 89  LEU A C   1 
ATOM   682  O O   . LEU A 1 88  ? 14.50942 -21.09439 15.71276  1.000 25.75422 ? 89  LEU A O   1 
ATOM   683  C CB  . LEU A 1 88  ? 13.86935 -19.50894 18.17618  1.000 20.72516 ? 89  LEU A CB  1 
ATOM   684  C CG  . LEU A 1 88  ? 13.81086 -18.28079 19.09012  1.000 23.56428 ? 89  LEU A CG  1 
ATOM   685  C CD1 . LEU A 1 88  ? 12.38163 -17.87287 19.43693  1.000 23.19686 ? 89  LEU A CD1 1 
ATOM   686  C CD2 . LEU A 1 88  ? 14.61855 -18.55052 20.36479  1.000 25.73191 ? 89  LEU A CD2 1 
ATOM   687  N N   . ARG A 1 89  ? 15.95604 -22.15790 17.06890  1.000 26.34602 ? 90  ARG A N   1 
ATOM   688  C CA  . ARG A 1 89  ? 15.86300 -23.41341 16.33530  1.000 27.00748 ? 90  ARG A CA  1 
ATOM   689  C C   . ARG A 1 89  ? 14.58119 -24.11737 16.73628  1.000 31.44625 ? 90  ARG A C   1 
ATOM   690  O O   . ARG A 1 89  ? 14.32433 -24.31267 17.92719  1.000 29.15810 ? 90  ARG A O   1 
ATOM   691  C CB  . ARG A 1 89  ? 17.05548 -24.31820 16.64897  1.000 33.98811 ? 90  ARG A CB  1 
ATOM   692  C CG  . ARG A 1 89  ? 18.18293 -24.26390 15.65962  1.000 38.52634 ? 90  ARG A CG  1 
ATOM   693  C CD  . ARG A 1 89  ? 17.92795 -25.14472 14.45037  1.000 40.62183 ? 90  ARG A CD  1 
ATOM   694  N NE  . ARG A 1 89  ? 18.62698 -24.59874 13.29058  1.000 42.40150 ? 90  ARG A NE  1 
ATOM   695  C CZ  . ARG A 1 89  ? 18.94927 -25.28863 12.20132  1.000 47.26992 ? 90  ARG A CZ  1 
ATOM   696  N NH1 . ARG A 1 89  ? 19.58126 -24.68719 11.20013  1.000 49.94484 ? 90  ARG A NH1 1 
ATOM   697  N NH2 . ARG A 1 89  ? 18.63768 -26.57506 12.10750  1.000 54.43053 ? 90  ARG A NH2 1 
ATOM   698  N N   . VAL A 1 90  ? 13.77938 -24.50777 15.74896  1.000 30.35320 ? 91  VAL A N   1 
ATOM   699  C CA  . VAL A 1 90  ? 12.54133 -25.22631 15.99705  1.000 28.34382 ? 91  VAL A CA  1 
ATOM   700  C C   . VAL A 1 90  ? 12.63829 -26.58594 15.31419  1.000 27.87259 ? 91  VAL A C   1 
ATOM   701  O O   . VAL A 1 90  ? 13.43602 -26.78944 14.39654  1.000 30.31188 ? 91  VAL A O   1 
ATOM   702  C CB  . VAL A 1 90  ? 11.31661 -24.43816 15.50117  1.000 31.19772 ? 91  VAL A CB  1 
ATOM   703  C CG1 . VAL A 1 90  ? 11.16934 -23.14408 16.30106  1.000 29.21597 ? 91  VAL A CG1 1 
ATOM   704  C CG2 . VAL A 1 90  ? 11.45740 -24.15143 14.01180  1.000 29.36463 ? 91  VAL A CG2 1 
ATOM   705  N N   . ASP A 1 91  ? 11.81887 -27.52835 15.77413  1.000 30.09425 ? 92  ASP A N   1 
ATOM   706  C CA  . ASP A 1 91  ? 11.96906 -28.89798 15.28670  1.000 35.36980 ? 92  ASP A CA  1 
ATOM   707  C C   . ASP A 1 91  ? 11.27723 -29.14703 13.95383  1.000 36.69108 ? 92  ASP A C   1 
ATOM   708  O O   . ASP A 1 91  ? 11.38573 -30.25251 13.41941  1.000 38.37234 ? 92  ASP A O   1 
ATOM   709  C CB  . ASP A 1 91  ? 11.45783 -29.90142 16.32439  1.000 34.30631 ? 92  ASP A CB  1 
ATOM   710  C CG  . ASP A 1 91  ? 10.03944 -29.62532 16.76636  1.000 41.18340 ? 92  ASP A CG  1 
ATOM   711  O OD1 . ASP A 1 91  ? 9.28703  -28.93283 16.04123  1.000 41.00450 ? 92  ASP A OD1 1 
ATOM   712  O OD2 . ASP A 1 91  ? 9.67416  -30.10928 17.85998  1.000 45.32035 ? 92  ASP A OD2 1 
ATOM   713  N N   . THR A 1 92  ? 10.58726 -28.15789 13.39755  1.000 33.44444 ? 93  THR A N   1 
ATOM   714  C CA  . THR A 1 92  ? 9.88408  -28.30461 12.12987  1.000 34.46688 ? 93  THR A CA  1 
ATOM   715  C C   . THR A 1 92  ? 10.37060 -27.23568 11.16700  1.000 30.55188 ? 93  THR A C   1 
ATOM   716  O O   . THR A 1 92  ? 10.50728 -26.07295 11.54952  1.000 30.32551 ? 93  THR A O   1 
ATOM   717  C CB  . THR A 1 92  ? 8.37517  -28.17861 12.32232  1.000 35.61869 ? 93  THR A CB  1 
ATOM   718  O OG1 . THR A 1 92  ? 7.92233  -29.20738 13.20733  1.000 42.50352 ? 93  THR A OG1 1 
ATOM   719  C CG2 . THR A 1 92  ? 7.66202  -28.31121 10.99315  1.000 30.92340 ? 93  THR A CG2 1 
ATOM   720  N N   . ALA A 1 93  ? 10.65483 -27.62396 9.93073   1.000 30.62931 ? 94  ALA A N   1 
ATOM   721  C CA  . ALA A 1 93  ? 10.95954 -26.62389 8.92264   1.000 31.11724 ? 94  ALA A CA  1 
ATOM   722  C C   . ALA A 1 93  ? 9.65730  -26.09668 8.33087   1.000 32.43974 ? 94  ALA A C   1 
ATOM   723  O O   . ALA A 1 93  ? 8.70001  -26.85084 8.11480   1.000 30.54356 ? 94  ALA A O   1 
ATOM   724  C CB  . ALA A 1 93  ? 11.86243 -27.20054 7.83406   1.000 27.82994 ? 94  ALA A CB  1 
ATOM   725  N N   . ASN A 1 94  ? 9.61300  -24.78980 8.10264   1.000 28.58871 ? 95  ASN A N   1 
ATOM   726  C CA  . ASN A 1 94  ? 8.42279  -24.16663 7.56056   1.000 27.24246 ? 95  ASN A CA  1 
ATOM   727  C C   . ASN A 1 94  ? 8.15890  -24.71298 6.16482   1.000 25.84047 ? 95  ASN A C   1 
ATOM   728  O O   . ASN A 1 94  ? 8.98392  -24.50277 5.25919   1.000 25.29907 ? 95  ASN A O   1 
ATOM   729  C CB  . ASN A 1 94  ? 8.58340  -22.64648 7.51514   1.000 25.22327 ? 95  ASN A CB  1 
ATOM   730  C CG  . ASN A 1 94  ? 7.27974  -21.92770 7.18737   1.000 27.82156 ? 95  ASN A CG  1 
ATOM   731  O OD1 . ASN A 1 94  ? 6.28153  -22.55077 6.83419   1.000 29.35486 ? 95  ASN A OD1 1 
ATOM   732  N ND2 . ASN A 1 94  ? 7.29212  -20.60086 7.29812   1.000 24.83520 ? 95  ASN A ND2 1 
ATOM   733  N N   . PRO A 1 95  ? 7.04853  -25.42184 5.94652   1.000 27.39743 ? 96  PRO A N   1 
ATOM   734  C CA  . PRO A 1 95  ? 6.75920  -25.92683 4.59370   1.000 27.02105 ? 96  PRO A CA  1 
ATOM   735  C C   . PRO A 1 95  ? 6.43160  -24.82060 3.60878   1.000 30.96386 ? 96  PRO A C   1 
ATOM   736  O O   . PRO A 1 95  ? 6.47632  -25.05591 2.39625   1.000 34.04951 ? 96  PRO A O   1 
ATOM   737  C CB  . PRO A 1 95  ? 5.55849  -26.84493 4.81759   1.000 31.62625 ? 96  PRO A CB  1 
ATOM   738  C CG  . PRO A 1 95  ? 4.83215  -26.19093 5.95631   1.000 32.87393 ? 96  PRO A CG  1 
ATOM   739  C CD  . PRO A 1 95  ? 5.90545  -25.59750 6.85770   1.000 27.40199 ? 96  PRO A CD  1 
ATOM   740  N N   . LYS A 1 96  ? 6.11051  -23.62096 4.09108   1.000 31.73868 ? 97  LYS A N   1 
ATOM   741  C CA  . LYS A 1 96  ? 5.81272  -22.47927 3.23724   1.000 29.93128 ? 97  LYS A CA  1 
ATOM   742  C C   . LYS A 1 96  ? 7.01120  -21.54803 3.06615   1.000 31.80066 ? 97  LYS A C   1 
ATOM   743  O O   . LYS A 1 96  ? 6.83768  -20.39690 2.64332   1.000 29.92877 ? 97  LYS A O   1 
ATOM   744  C CB  . LYS A 1 96  ? 4.61561  -21.71433 3.79816   1.000 32.94796 ? 97  LYS A CB  1 
ATOM   745  C CG  . LYS A 1 96  ? 3.29348  -22.45811 3.68254   1.000 39.02352 ? 97  LYS A CG  1 
ATOM   746  C CD  . LYS A 1 96  ? 2.12487  -21.58972 4.11976   1.000 42.65101 ? 97  LYS A CD  1 
ATOM   747  C CE  . LYS A 1 96  ? 1.04181  -22.42004 4.79375   1.000 47.27642 ? 97  LYS A CE  1 
ATOM   748  N NZ  . LYS A 1 96  ? 0.21200  -21.59926 5.71495   1.000 52.72064 ? 97  LYS A NZ  1 
ATOM   749  N N   . THR A 1 97  ? 8.21536  -22.01587 3.39469   1.000 29.72487 ? 98  THR A N   1 
ATOM   750  C CA  . THR A 1 97  ? 9.43062  -21.22729 3.22122   1.000 28.54300 ? 98  THR A CA  1 
ATOM   751  C C   . THR A 1 97  ? 9.61222  -20.88144 1.75243   1.000 33.36244 ? 98  THR A C   1 
ATOM   752  O O   . THR A 1 97  ? 9.66886  -21.79631 0.91667   1.000 29.09803 ? 98  THR A O   1 
ATOM   753  C CB  . THR A 1 97  ? 10.66471 -21.98523 3.71607   1.000 30.49279 ? 98  THR A CB  1 
ATOM   754  O OG1 . THR A 1 97  ? 10.52591 -22.26540 5.10917   1.000 26.98427 ? 98  THR A OG1 1 
ATOM   755  C CG2 . THR A 1 97  ? 11.93408 -21.15696 3.49790   1.000 29.65079 ? 98  THR A CG2 1 
ATOM   756  N N   . PRO A 1 98  ? 9.70591  -19.60164 1.39204   1.000 29.78698 ? 99  PRO A N   1 
ATOM   757  C CA  . PRO A 1 98  ? 9.98452  -19.23066 0.00560   1.000 28.32449 ? 99  PRO A CA  1 
ATOM   758  C C   . PRO A 1 98  ? 11.48078 -19.23616 -0.26794  1.000 24.56084 ? 99  PRO A C   1 
ATOM   759  O O   . PRO A 1 98  ? 12.31017 -19.37112 0.63286   1.000 27.21809 ? 99  PRO A O   1 
ATOM   760  C CB  . PRO A 1 98  ? 9.42176  -17.80150 -0.08820  1.000 26.88039 ? 99  PRO A CB  1 
ATOM   761  C CG  . PRO A 1 98  ? 9.74381  -17.24000 1.27522   1.000 25.38975 ? 99  PRO A CG  1 
ATOM   762  C CD  . PRO A 1 98  ? 9.52462  -18.41276 2.24626   1.000 28.63851 ? 99  PRO A CD  1 
ATOM   763  N N   . LYS A 1 99  ? 11.81325 -19.11564 -1.55037  1.000 23.19067 ? 100 LYS A N   1 
ATOM   764  C CA  . LYS A 1 99  ? 13.16836 -18.72931 -1.91516  1.000 27.43120 ? 100 LYS A CA  1 
ATOM   765  C C   . LYS A 1 99  ? 13.44606 -17.34158 -1.34844  1.000 27.95503 ? 100 LYS A C   1 
ATOM   766  O O   . LYS A 1 99  ? 12.62559 -16.43290 -1.49618  1.000 28.85816 ? 100 LYS A O   1 
ATOM   767  C CB  . LYS A 1 99  ? 13.33345 -18.71372 -3.43520  1.000 30.90217 ? 100 LYS A CB  1 
ATOM   768  C CG  . LYS A 1 99  ? 13.00135 -20.00974 -4.13381  1.000 33.11349 ? 100 LYS A CG  1 
ATOM   769  C CD  . LYS A 1 99  ? 13.56322 -19.98848 -5.55139  1.000 36.25755 ? 100 LYS A CD  1 
ATOM   770  C CE  . LYS A 1 99  ? 13.50727 -21.35291 -6.18736  1.000 40.58491 ? 100 LYS A CE  1 
ATOM   771  N NZ  . LYS A 1 99  ? 12.61471 -21.35324 -7.37834  1.000 48.88822 ? 100 LYS A NZ  1 
ATOM   772  N N   . TYR A 1 100 ? 14.59547 -17.16789 -0.70485  1.000 28.74444 ? 101 TYR A N   1 
ATOM   773  C CA  . TYR A 1 100 ? 14.86608 -15.89783 -0.04575  1.000 26.50118 ? 101 TYR A CA  1 
ATOM   774  C C   . TYR A 1 100 ? 16.36438 -15.65133 0.04793   1.000 29.36388 ? 101 TYR A C   1 
ATOM   775  O O   . TYR A 1 100 ? 17.17770 -16.56844 -0.08950  1.000 26.98000 ? 101 TYR A O   1 
ATOM   776  C CB  . TYR A 1 100 ? 14.24209 -15.85923 1.35335   1.000 25.36907 ? 101 TYR A CB  1 
ATOM   777  C CG  . TYR A 1 100 ? 14.97003 -16.73917 2.34316   1.000 26.49703 ? 101 TYR A CG  1 
ATOM   778  C CD1 . TYR A 1 100 ? 14.72316 -18.10359 2.39793   1.000 29.04350 ? 101 TYR A CD1 1 
ATOM   779  C CD2 . TYR A 1 100 ? 15.91400 -16.20839 3.19950   1.000 25.26813 ? 101 TYR A CD2 1 
ATOM   780  C CE1 . TYR A 1 100 ? 15.39618 -18.91519 3.29990   1.000 26.23915 ? 101 TYR A CE1 1 
ATOM   781  C CE2 . TYR A 1 100 ? 16.59409 -17.00841 4.09636   1.000 27.40192 ? 101 TYR A CE2 1 
ATOM   782  C CZ  . TYR A 1 100 ? 16.32495 -18.35607 4.14110   1.000 28.23956 ? 101 TYR A CZ  1 
ATOM   783  O OH  . TYR A 1 100 ? 16.99876 -19.14593 5.03165   1.000 33.57288 ? 101 TYR A OH  1 
ATOM   784  N N   . LYS A 1 101 ? 16.71648 -14.38695 0.28325   1.000 26.19333 ? 102 LYS A N   1 
ATOM   785  C CA  . LYS A 1 101 ? 18.05722 -13.99949 0.70154   1.000 26.11848 ? 102 LYS A CA  1 
ATOM   786  C C   . LYS A 1 101 ? 17.95081 -12.83663 1.67541   1.000 24.07650 ? 102 LYS A C   1 
ATOM   787  O O   . LYS A 1 101 ? 16.94973 -12.11533 1.70670   1.000 22.63921 ? 102 LYS A O   1 
ATOM   788  C CB  . LYS A 1 101 ? 18.96364 -13.60506 -0.47706  1.000 31.49855 ? 102 LYS A CB  1 
ATOM   789  C CG  . LYS A 1 101 ? 18.44121 -12.48851 -1.34904  1.000 33.12885 ? 102 LYS A CG  1 
ATOM   790  C CD  . LYS A 1 101 ? 19.35291 -12.24370 -2.56012  1.000 39.00542 ? 102 LYS A CD  1 
ATOM   791  C CE  . LYS A 1 101 ? 19.37176 -13.45034 -3.50188  1.000 43.07151 ? 102 LYS A CE  1 
ATOM   792  N NZ  . LYS A 1 101 ? 19.97985 -13.13461 -4.83800  1.000 47.60534 ? 102 LYS A NZ  1 
ATOM   793  N N   . PHE A 1 102 ? 18.99480 -12.66924 2.47998   1.000 21.86187 ? 103 PHE A N   1 
ATOM   794  C CA  . PHE A 1 102 ? 19.11213 -11.53651 3.39017   1.000 23.01638 ? 103 PHE A CA  1 
ATOM   795  C C   . PHE A 1 102 ? 19.98007 -10.46570 2.74149   1.000 27.84294 ? 103 PHE A C   1 
ATOM   796  O O   . PHE A 1 102 ? 21.09695 -10.75656 2.29966   1.000 27.80514 ? 103 PHE A O   1 
ATOM   797  C CB  . PHE A 1 102 ? 19.73235 -11.95686 4.72635   1.000 22.14236 ? 103 PHE A CB  1 
ATOM   798  C CG  . PHE A 1 102 ? 18.86754 -12.86368 5.55786   1.000 21.19336 ? 103 PHE A CG  1 
ATOM   799  C CD1 . PHE A 1 102 ? 17.52042 -13.02776 5.28120   1.000 21.89865 ? 103 PHE A CD1 1 
ATOM   800  C CD2 . PHE A 1 102 ? 19.42615 -13.56989 6.63340   1.000 20.08184 ? 103 PHE A CD2 1 
ATOM   801  C CE1 . PHE A 1 102 ? 16.73335 -13.86335 6.04164   1.000 22.05806 ? 103 PHE A CE1 1 
ATOM   802  C CE2 . PHE A 1 102 ? 18.64678 -14.41715 7.39591   1.000 18.83374 ? 103 PHE A CE2 1 
ATOM   803  C CZ  . PHE A 1 102 ? 17.29861 -14.56379 7.10689   1.000 22.55844 ? 103 PHE A CZ  1 
ATOM   804  N N   . VAL A 1 103 ? 19.47798 -9.22678  2.69259   1.000 21.71796 ? 104 VAL A N   1 
ATOM   805  C CA  . VAL A 1 103 ? 20.19778 -8.12538  2.07139   1.000 21.07323 ? 104 VAL A CA  1 
ATOM   806  C C   . VAL A 1 103 ? 20.17800 -6.93447  3.01392   1.000 22.84702 ? 104 VAL A C   1 
ATOM   807  O O   . VAL A 1 103 ? 19.22407 -6.72930  3.76951   1.000 24.98638 ? 104 VAL A O   1 
ATOM   808  C CB  . VAL A 1 103 ? 19.60514 -7.73488  0.69275   1.000 25.03533 ? 104 VAL A CB  1 
ATOM   809  C CG1 . VAL A 1 103 ? 19.48216 -8.95854  -0.19761  1.000 25.81988 ? 104 VAL A CG1 1 
ATOM   810  C CG2 . VAL A 1 103 ? 18.24330 -7.08949  0.85001   1.000 25.09968 ? 104 VAL A CG2 1 
ATOM   811  N N   . ARG A 1 104 ? 21.25021 -6.16659  2.99182   1.000 21.89884 ? 105 ARG A N   1 
ATOM   812  C CA  . ARG A 1 104 ? 21.33456 -4.92954  3.75249   1.000 20.44500 ? 105 ARG A CA  1 
ATOM   813  C C   . ARG A 1 104 ? 21.19418 -3.80494  2.74843   1.000 22.44523 ? 105 ARG A C   1 
ATOM   814  O O   . ARG A 1 104 ? 22.02673 -3.67987  1.84720   1.000 26.01205 ? 105 ARG A O   1 
ATOM   815  C CB  . ARG A 1 104 ? 22.65400 -4.81847  4.52406   1.000 22.38742 ? 105 ARG A CB  1 
ATOM   816  C CG  . ARG A 1 104 ? 22.70937 -3.60783  5.45563   1.000 22.22814 ? 105 ARG A CG  1 
ATOM   817  C CD  . ARG A 1 104 ? 23.95175 -3.58367  6.33866   1.000 25.51227 ? 105 ARG A CD  1 
ATOM   818  N NE  . ARG A 1 104 ? 23.98596 -2.37855  7.16814   1.000 27.73441 ? 105 ARG A NE  1 
ATOM   819  C CZ  . ARG A 1 104 ? 23.42616 -2.27244  8.37053   1.000 23.09291 ? 105 ARG A CZ  1 
ATOM   820  N NH1 . ARG A 1 104 ? 22.78844 -3.30409  8.90915   1.000 20.78446 ? 105 ARG A NH1 1 
ATOM   821  N NH2 . ARG A 1 104 ? 23.50818 -1.13083  9.03774   1.000 22.56141 ? 105 ARG A NH2 1 
ATOM   822  N N   . ILE A 1 105 ? 20.13855 -3.00676  2.88459   1.000 23.16405 ? 106 ILE A N   1 
ATOM   823  C CA  . ILE A 1 105 ? 19.85135 -1.97941  1.89307   1.000 22.05102 ? 106 ILE A CA  1 
ATOM   824  C C   . ILE A 1 105 ? 20.53730 -0.67965  2.27256   1.000 23.70571 ? 106 ILE A C   1 
ATOM   825  O O   . ILE A 1 105 ? 21.05470 -0.52846  3.38530   1.000 22.11531 ? 106 ILE A O   1 
ATOM   826  C CB  . ILE A 1 105 ? 18.33826 -1.76062  1.71170   1.000 23.25919 ? 106 ILE A CB  1 
ATOM   827  C CG1 . ILE A 1 105 ? 17.67996 -1.39053  3.04402   1.000 22.94948 ? 106 ILE A CG1 1 
ATOM   828  C CG2 . ILE A 1 105 ? 17.70357 -2.98737  1.04995   1.000 25.85563 ? 106 ILE A CG2 1 
ATOM   829  C CD1 . ILE A 1 105 ? 16.33488 -0.68942  2.88454   1.000 23.91207 ? 106 ILE A CD1 1 
ATOM   830  N N   . GLN A 1 106 ? 20.54348 0.24902   1.35320   1.000 26.27832 ? 107 GLN A N   1 
ATOM   831  C CA  . GLN A 1 106 ? 21.13902 1.57284   1.33510   1.000 25.46122 ? 107 GLN A CA  1 
ATOM   832  C C   . GLN A 1 106 ? 20.09504 2.63766   1.63007   1.000 27.20025 ? 107 GLN A C   1 
ATOM   833  O O   . GLN A 1 106 ? 18.93679 2.50456   1.22529   1.000 25.30619 ? 107 GLN A O   1 
ATOM   834  C CB  . GLN A 1 106 ? 21.76116 1.86680   -0.03180  1.000 27.99304 ? 107 GLN A CB  1 
ATOM   835  C CG  . GLN A 1 106 ? 22.93531 0.99014   -0.38346  1.000 34.74844 ? 107 GLN A CG  1 
ATOM   836  C CD  . GLN A 1 106 ? 24.09338 1.20561   0.54770   1.000 35.37902 ? 107 GLN A CD  1 
ATOM   837  O OE1 . GLN A 1 106 ? 24.46892 2.34571   0.82989   1.000 42.79279 ? 107 GLN A OE1 1 
ATOM   838  N NE2 . GLN A 1 106 ? 24.66795 0.11459   1.04532   1.000 43.21348 ? 107 GLN A NE2 1 
ATOM   839  N N   . PRO A 1 107 ? 20.50133 3.70958   2.30612   1.000 24.94886 ? 108 PRO A N   1 
ATOM   840  C CA  . PRO A 1 107 ? 19.57670 4.82485   2.53492   1.000 26.88115 ? 108 PRO A CA  1 
ATOM   841  C C   . PRO A 1 107 ? 19.01846 5.33457   1.21487   1.000 25.96109 ? 108 PRO A C   1 
ATOM   842  O O   . PRO A 1 107 ? 19.71737 5.39311   0.19670   1.000 23.81763 ? 108 PRO A O   1 
ATOM   843  C CB  . PRO A 1 107 ? 20.44477 5.87403   3.23898   1.000 27.91878 ? 108 PRO A CB  1 
ATOM   844  C CG  . PRO A 1 107 ? 21.87908 5.41293   3.03885   1.000 26.60557 ? 108 PRO A CG  1 
ATOM   845  C CD  . PRO A 1 107 ? 21.83527 3.94910   2.88774   1.000 27.84054 ? 108 PRO A CD  1 
ATOM   846  N N   . GLY A 1 108 ? 17.72583 5.65225   1.22415   1.000 23.03214 ? 109 GLY A N   1 
ATOM   847  C CA  . GLY A 1 108 ? 17.01514 6.00236   0.01715   1.000 23.73388 ? 109 GLY A CA  1 
ATOM   848  C C   . GLY A 1 108 ? 16.29771 4.85241   -0.65892  1.000 25.36705 ? 109 GLY A C   1 
ATOM   849  O O   . GLY A 1 108 ? 15.38556 5.09259   -1.45725  1.000 26.19113 ? 109 GLY A O   1 
ATOM   850  N N   . GLN A 1 109 ? 16.68821 3.61048   -0.38511  1.000 20.88038 ? 110 GLN A N   1 
ATOM   851  C CA  . GLN A 1 109 ? 16.02868 2.48265   -1.01489  1.000 21.86634 ? 110 GLN A CA  1 
ATOM   852  C C   . GLN A 1 109 ? 14.68784 2.21137   -0.33691  1.000 21.65493 ? 110 GLN A C   1 
ATOM   853  O O   . GLN A 1 109 ? 14.47998 2.54953   0.83600   1.000 22.90296 ? 110 GLN A O   1 
ATOM   854  C CB  . GLN A 1 109 ? 16.93369 1.24575   -0.97478  1.000 24.46719 ? 110 GLN A CB  1 
ATOM   855  C CG  . GLN A 1 109 ? 18.22443 1.45303   -1.77889  1.000 27.95015 ? 110 GLN A CG  1 
ATOM   856  C CD  . GLN A 1 109 ? 18.96883 0.16210   -2.11490  1.000 32.41683 ? 110 GLN A CD  1 
ATOM   857  O OE1 . GLN A 1 109 ? 19.38009 -0.59765  -1.23282  1.000 31.27421 ? 110 GLN A OE1 1 
ATOM   858  N NE2 . GLN A 1 109 ? 19.16156 -0.07541  -3.40541  1.000 35.77541 ? 110 GLN A NE2 1 
ATOM   859  N N   . THR A 1 110 ? 13.76868 1.61005   -1.09098  1.000 18.48793 ? 111 THR A N   1 
ATOM   860  C CA  . THR A 1 110 ? 12.42824 1.32198   -0.58944  1.000 20.36582 ? 111 THR A CA  1 
ATOM   861  C C   . THR A 1 110 ? 12.20637 -0.17823  -0.45097  1.000 18.34004 ? 111 THR A C   1 
ATOM   862  O O   . THR A 1 110 ? 12.94787 -0.99684  -0.99614  1.000 19.23980 ? 111 THR A O   1 
ATOM   863  C CB  . THR A 1 110 ? 11.35803 1.90700   -1.51005  1.000 18.85394 ? 111 THR A CB  1 
ATOM   864  O OG1 . THR A 1 110 ? 11.46038 1.28712   -2.79559  1.000 20.97203 ? 111 THR A OG1 1 
ATOM   865  C CG2 . THR A 1 110 ? 11.54377 3.42264   -1.61592  1.000 21.64283 ? 111 THR A CG2 1 
ATOM   866  N N   . PHE A 1 111 ? 11.13947 -0.52255  0.27019   1.000 17.49471 ? 112 PHE A N   1 
ATOM   867  C CA  . PHE A 1 111 ? 10.78522 -1.91249  0.52238   1.000 18.13238 ? 112 PHE A CA  1 
ATOM   868  C C   . PHE A 1 111 ? 9.34486  -1.94514  0.99426   1.000 16.95736 ? 112 PHE A C   1 
ATOM   869  O O   . PHE A 1 111 ? 8.77515  -0.91053  1.35325   1.000 17.88786 ? 112 PHE A O   1 
ATOM   870  C CB  . PHE A 1 111 ? 11.70160 -2.55327  1.56549   1.000 16.22922 ? 112 PHE A CB  1 
ATOM   871  C CG  . PHE A 1 111 ? 11.82118 -1.76391  2.83774   1.000 16.85707 ? 112 PHE A CG  1 
ATOM   872  C CD1 . PHE A 1 111 ? 12.78751 -0.77820  2.95932   1.000 18.46606 ? 112 PHE A CD1 1 
ATOM   873  C CD2 . PHE A 1 111 ? 10.99976 -2.03586  3.91864   1.000 17.38516 ? 112 PHE A CD2 1 
ATOM   874  C CE1 . PHE A 1 111 ? 12.92571 -0.05727  4.13004   1.000 21.55225 ? 112 PHE A CE1 1 
ATOM   875  C CE2 . PHE A 1 111 ? 11.13603 -1.32276  5.10703   1.000 19.30000 ? 112 PHE A CE2 1 
ATOM   876  C CZ  . PHE A 1 111 ? 12.09515 -0.32408  5.20999   1.000 23.29203 ? 112 PHE A CZ  1 
ATOM   877  N N   . SER A 1 112 ? 8.75228  -3.13553  0.94201   1.000 14.46491 ? 113 SER A N   1 
ATOM   878  C CA  . SER A 1 112 ? 7.40772  -3.34708  1.45795   1.000 15.10569 ? 113 SER A CA  1 
ATOM   879  C C   . SER A 1 112 ? 7.51464  -3.83228  2.89448   1.000 16.37387 ? 113 SER A C   1 
ATOM   880  O O   . SER A 1 112 ? 8.41543  -4.60256  3.21935   1.000 16.74536 ? 113 SER A O   1 
ATOM   881  C CB  . SER A 1 112 ? 6.64755  -4.37300  0.61353   1.000 15.69149 ? 113 SER A CB  1 
ATOM   882  O OG  . SER A 1 112 ? 6.39339  -3.83396  -0.66970  1.000 18.84346 ? 113 SER A OG  1 
ATOM   883  N N   . VAL A 1 113 ? 6.60105  -3.37034  3.74791   1.000 15.85847 ? 114 VAL A N   1 
ATOM   884  C CA  . VAL A 1 113 ? 6.51688  -3.81057  5.13459   1.000 15.74723 ? 114 VAL A CA  1 
ATOM   885  C C   . VAL A 1 113 ? 5.24161  -4.60980  5.28813   1.000 14.96524 ? 114 VAL A C   1 
ATOM   886  O O   . VAL A 1 113 ? 4.17033  -4.15455  4.87587   1.000 15.58784 ? 114 VAL A O   1 
ATOM   887  C CB  . VAL A 1 113 ? 6.50224  -2.63769  6.12801   1.000 16.49315 ? 114 VAL A CB  1 
ATOM   888  C CG1 . VAL A 1 113 ? 6.21677  -3.18198  7.52579   1.000 21.02504 ? 114 VAL A CG1 1 
ATOM   889  C CG2 . VAL A 1 113 ? 7.79964  -1.87462  6.12036   1.000 16.42610 ? 114 VAL A CG2 1 
ATOM   890  N N   . LEU A 1 114 ? 5.34576  -5.78734  5.88232   1.000 13.83116 ? 115 LEU A N   1 
ATOM   891  C CA  . LEU A 1 114 ? 4.16190  -6.56863  6.21557   1.000 18.70315 ? 115 LEU A CA  1 
ATOM   892  C C   . LEU A 1 114 ? 3.98448  -6.42097  7.71212   1.000 17.25701 ? 115 LEU A C   1 
ATOM   893  O O   . LEU A 1 114 ? 4.67436  -7.08208  8.49220   1.000 17.09715 ? 115 LEU A O   1 
ATOM   894  C CB  . LEU A 1 114 ? 4.30055  -8.01936  5.78884   1.000 15.32203 ? 115 LEU A CB  1 
ATOM   895  C CG  . LEU A 1 114 ? 3.11583  -8.90080  6.21698   1.000 18.38548 ? 115 LEU A CG  1 
ATOM   896  C CD1 . LEU A 1 114 ? 1.81811  -8.41862  5.60404   1.000 19.35218 ? 115 LEU A CD1 1 
ATOM   897  C CD2 . LEU A 1 114 ? 3.38656  -10.35867 5.86102   1.000 16.90228 ? 115 LEU A CD2 1 
ATOM   898  N N   . ALA A 1 115 ? 3.07744  -5.52566  8.10094   1.000 16.60242 ? 116 ALA A N   1 
ATOM   899  C CA  . ALA A 1 115 ? 2.86199  -5.21386  9.50961   1.000 21.21090 ? 116 ALA A CA  1 
ATOM   900  C C   . ALA A 1 115 ? 2.08062  -6.34099  10.16538  1.000 20.15211 ? 116 ALA A C   1 
ATOM   901  O O   . ALA A 1 115 ? 1.06156  -6.79453  9.64321   1.000 20.98157 ? 116 ALA A O   1 
ATOM   902  C CB  . ALA A 1 115 ? 2.11158  -3.89059  9.66442   1.000 19.19611 ? 116 ALA A CB  1 
ATOM   903  N N   . CYS A 1 116 ? 2.56639  -6.79316  11.31397  1.000 17.63509 ? 117 CYS A N   1 
ATOM   904  C CA  . CYS A 1 116 ? 2.03928  -7.98438  11.95730  1.000 19.94733 ? 117 CYS A CA  1 
ATOM   905  C C   . CYS A 1 116 ? 1.86053  -7.69401  13.43396  1.000 20.90653 ? 117 CYS A C   1 
ATOM   906  O O   . CYS A 1 116 ? 2.62648  -6.92388  14.01267  1.000 19.09603 ? 117 CYS A O   1 
ATOM   907  C CB  . CYS A 1 116 ? 2.98184  -9.17731  11.78393  1.000 20.87276 ? 117 CYS A CB  1 
ATOM   908  S SG  . CYS A 1 116 ? 3.12711  -9.75575  10.08771  1.000 25.27890 ? 117 CYS A SG  1 
ATOM   909  N N   . TYR A 1 117 ? 0.83275  -8.30628  14.02456  1.000 23.21076 ? 118 TYR A N   1 
ATOM   910  C CA  . TYR A 1 117 ? 0.58891  -8.25182  15.46293  1.000 21.85550 ? 118 TYR A CA  1 
ATOM   911  C C   . TYR A 1 117 ? 0.22166  -9.64845  15.93169  1.000 24.95852 ? 118 TYR A C   1 
ATOM   912  O O   . TYR A 1 117 ? -0.57633 -10.32749 15.28318  1.000 24.92482 ? 118 TYR A O   1 
ATOM   913  C CB  . TYR A 1 117 ? -0.51469 -7.23379  15.79951  1.000 24.03215 ? 118 TYR A CB  1 
ATOM   914  C CG  . TYR A 1 117 ? -0.08794 -5.86543  15.32963  1.000 23.74030 ? 118 TYR A CG  1 
ATOM   915  C CD1 . TYR A 1 117 ? 0.75262  -5.09375  16.10544  1.000 17.02737 ? 118 TYR A CD1 1 
ATOM   916  C CD2 . TYR A 1 117 ? -0.44648 -5.38507  14.06614  1.000 24.04018 ? 118 TYR A CD2 1 
ATOM   917  C CE1 . TYR A 1 117 ? 1.20275  -3.85933  15.67688  1.000 22.39838 ? 118 TYR A CE1 1 
ATOM   918  C CE2 . TYR A 1 117 ? -0.00141 -4.13847  13.62395  1.000 22.68122 ? 118 TYR A CE2 1 
ATOM   919  C CZ  . TYR A 1 117 ? 0.82944  -3.38797  14.42885  1.000 20.94516 ? 118 TYR A CZ  1 
ATOM   920  O OH  . TYR A 1 117 ? 1.30177  -2.15555  14.02800  1.000 20.73027 ? 118 TYR A OH  1 
ATOM   921  N N   . ASN A 1 118 ? 0.83527  -10.08442 17.03894  1.000 25.95659 ? 119 ASN A N   1 
ATOM   922  C CA  . ASN A 1 118 ? 0.61332  -11.42812 17.58269  1.000 25.96540 ? 119 ASN A CA  1 
ATOM   923  C C   . ASN A 1 118 ? 0.85471  -12.50610 16.53504  1.000 28.00041 ? 119 ASN A C   1 
ATOM   924  O O   . ASN A 1 118 ? 0.18845  -13.54284 16.52155  1.000 28.12150 ? 119 ASN A O   1 
ATOM   925  C CB  . ASN A 1 118 ? -0.79118 -11.57051 18.16598  1.000 30.59331 ? 119 ASN A CB  1 
ATOM   926  C CG  . ASN A 1 118 ? -1.13023 -10.46026 19.12041  1.000 28.61058 ? 119 ASN A CG  1 
ATOM   927  O OD1 . ASN A 1 118 ? -0.44782 -10.26939 20.12550  1.000 37.08456 ? 119 ASN A OD1 1 
ATOM   928  N ND2 . ASN A 1 118 ? -2.18252 -9.71197  18.81207  1.000 36.15235 ? 119 ASN A ND2 1 
ATOM   929  N N   . GLY A 1 119 ? 1.81192  -12.26802 15.64515  1.000 24.39931 ? 120 GLY A N   1 
ATOM   930  C CA  . GLY A 1 119 ? 2.14778  -13.23158 14.63391  1.000 21.39339 ? 120 GLY A CA  1 
ATOM   931  C C   . GLY A 1 119 ? 1.22439  -13.28169 13.42874  1.000 25.92445 ? 120 GLY A C   1 
ATOM   932  O O   . GLY A 1 119 ? 1.41038  -14.15709 12.57977  1.000 25.09395 ? 120 GLY A O   1 
ATOM   933  N N   . SER A 1 120 ? 0.25435  -12.37464 13.30998  1.000 25.86872 ? 121 SER A N   1 
ATOM   934  C CA  . SER A 1 120 ? -0.70503 -12.41723 12.20108  1.000 20.17840 ? 121 SER A CA  1 
ATOM   935  C C   . SER A 1 120 ? -0.58734 -11.17246 11.33652  1.000 24.82923 ? 121 SER A C   1 
ATOM   936  O O   . SER A 1 120 ? -0.66015 -10.05375 11.86185  1.000 23.67631 ? 121 SER A O   1 
ATOM   937  C CB  . SER A 1 120 ? -2.13626 -12.52767 12.72280  1.000 29.14472 ? 121 SER A CB  1 
ATOM   938  O OG  . SER A 1 120 ? -2.27077 -13.65593 13.56356  1.000 34.19185 ? 121 SER A OG  1 
ATOM   939  N N   . PRO A 1 121 ? -0.41843 -11.31588 10.02255  1.000 24.75404 ? 122 PRO A N   1 
ATOM   940  C CA  . PRO A 1 121 ? -0.31916 -10.12867 9.15886   1.000 23.87908 ? 122 PRO A CA  1 
ATOM   941  C C   . PRO A 1 121 ? -1.56632 -9.26650  9.25535   1.000 28.35660 ? 122 PRO A C   1 
ATOM   942  O O   . PRO A 1 121 ? -2.69044 -9.77065  9.24902   1.000 31.78441 ? 122 PRO A O   1 
ATOM   943  C CB  . PRO A 1 121 ? -0.15093 -10.72506 7.75858   1.000 27.00530 ? 122 PRO A CB  1 
ATOM   944  C CG  . PRO A 1 121 ? 0.45675  -12.08407 7.99666   1.000 28.50385 ? 122 PRO A CG  1 
ATOM   945  C CD  . PRO A 1 121 ? -0.16488 -12.56596 9.29056   1.000 27.57107 ? 122 PRO A CD  1 
ATOM   946  N N   . SER A 1 122 ? -1.36339 -7.94886  9.35300   1.000 23.38233 ? 123 SER A N   1 
ATOM   947  C CA  . SER A 1 122 ? -2.48392 -7.02430  9.38745   1.000 27.37356 ? 123 SER A CA  1 
ATOM   948  C C   . SER A 1 122 ? -2.53167 -6.05191  8.21305   1.000 23.02450 ? 123 SER A C   1 
ATOM   949  O O   . SER A 1 122 ? -3.62228 -5.61354  7.84214   1.000 25.25155 ? 123 SER A O   1 
ATOM   950  C CB  . SER A 1 122 ? -2.47974 -6.24737  10.71371  1.000 28.02809 ? 123 SER A CB  1 
ATOM   951  O OG  . SER A 1 122 ? -1.89588 -4.97469  10.59952  1.000 36.65676 ? 123 SER A OG  1 
ATOM   952  N N   . GLY A 1 123 ? -1.40247 -5.70731  7.61045   1.000 19.80851 ? 124 GLY A N   1 
ATOM   953  C CA  . GLY A 1 123 ? -1.43881 -4.78034  6.48621   1.000 20.21388 ? 124 GLY A CA  1 
ATOM   954  C C   . GLY A 1 123 ? -0.09080 -4.69829  5.80788   1.000 18.50084 ? 124 GLY A C   1 
ATOM   955  O O   . GLY A 1 123 ? 0.93237  -5.04062  6.39255   1.000 23.09192 ? 124 GLY A O   1 
ATOM   956  N N   . VAL A 1 124 ? -0.10074 -4.23667  4.55656   1.000 17.21633 ? 125 VAL A N   1 
ATOM   957  C CA  . VAL A 1 124 ? 1.13207  -4.13984  3.77565   1.000 15.93762 ? 125 VAL A CA  1 
ATOM   958  C C   . VAL A 1 124 ? 1.22030  -2.73632  3.18754   1.000 21.42082 ? 125 VAL A C   1 
ATOM   959  O O   . VAL A 1 124 ? 0.21706  -2.18359  2.72002   1.000 19.03013 ? 125 VAL A O   1 
ATOM   960  C CB  . VAL A 1 124 ? 1.21625  -5.23284  2.68036   1.000 20.50138 ? 125 VAL A CB  1 
ATOM   961  C CG1 . VAL A 1 124 ? 0.08073  -5.13272  1.68546   1.000 21.53113 ? 125 VAL A CG1 1 
ATOM   962  C CG2 . VAL A 1 124 ? 2.57172  -5.20627  1.97810   1.000 21.15480 ? 125 VAL A CG2 1 
ATOM   963  N N   . TYR A 1 125 ? 2.40678  -2.13263  3.27336   1.000 18.37486 ? 126 TYR A N   1 
ATOM   964  C CA  . TYR A 1 125 ? 2.60928  -0.80710  2.71547   1.000 18.85316 ? 126 TYR A CA  1 
ATOM   965  C C   . TYR A 1 125 ? 4.07522  -0.63897  2.34563   1.000 18.95850 ? 126 TYR A C   1 
ATOM   966  O O   . TYR A 1 125 ? 4.94768  -1.37204  2.81605   1.000 18.39335 ? 126 TYR A O   1 
ATOM   967  C CB  . TYR A 1 125 ? 2.17002  0.28089   3.69259   1.000 20.76728 ? 126 TYR A CB  1 
ATOM   968  C CG  . TYR A 1 125 ? 2.91481  0.23289   5.01128   1.000 19.10238 ? 126 TYR A CG  1 
ATOM   969  C CD1 . TYR A 1 125 ? 4.12100  0.89399   5.16572   1.000 18.44942 ? 126 TYR A CD1 1 
ATOM   970  C CD2 . TYR A 1 125 ? 2.40181  -0.46145  6.08998   1.000 19.93106 ? 126 TYR A CD2 1 
ATOM   971  C CE1 . TYR A 1 125 ? 4.80559  0.86995   6.36508   1.000 20.56055 ? 126 TYR A CE1 1 
ATOM   972  C CE2 . TYR A 1 125 ? 3.07700  -0.50203  7.29390   1.000 21.76392 ? 126 TYR A CE2 1 
ATOM   973  C CZ  . TYR A 1 125 ? 4.28140  0.17962   7.42456   1.000 21.08022 ? 126 TYR A CZ  1 
ATOM   974  O OH  . TYR A 1 125 ? 4.95828  0.15952   8.61690   1.000 23.21938 ? 126 TYR A OH  1 
ATOM   975  N N   . GLN A 1 126 ? 4.32528  0.33702   1.49009   1.000 17.20357 ? 127 GLN A N   1 
ATOM   976  C CA  . GLN A 1 126 ? 5.66395  0.64943   1.01538   1.000 16.48157 ? 127 GLN A CA  1 
ATOM   977  C C   . GLN A 1 126 ? 6.30233  1.69371   1.91393   1.000 21.61115 ? 127 GLN A C   1 
ATOM   978  O O   . GLN A 1 126 ? 5.65012  2.67192   2.29378   1.000 22.18859 ? 127 GLN A O   1 
ATOM   979  C CB  . GLN A 1 126 ? 5.58793  1.17633   -0.42050  1.000 20.01594 ? 127 GLN A CB  1 
ATOM   980  C CG  . GLN A 1 126 ? 6.90867  1.15669   -1.16406  1.000 26.06882 ? 127 GLN A CG  1 
ATOM   981  C CD  . GLN A 1 126 ? 7.26057  -0.21415  -1.69538  1.000 25.77684 ? 127 GLN A CD  1 
ATOM   982  O OE1 . GLN A 1 126 ? 6.66439  -1.22590  -1.30753  1.000 24.22719 ? 127 GLN A OE1 1 
ATOM   983  N NE2 . GLN A 1 126 ? 8.21837  -0.25328  -2.61573  1.000 30.14344 ? 127 GLN A NE2 1 
ATOM   984  N N   . CYS A 1 127 ? 7.59175  1.49615   2.21611   1.000 17.25517 ? 128 CYS A N   1 
ATOM   985  C CA  . CYS A 1 127 ? 8.38649  2.32672   3.09958   1.000 20.47485 ? 128 CYS A CA  1 
ATOM   986  C C   . CYS A 1 127 ? 9.73179  2.59582   2.43611   1.000 19.07238 ? 128 CYS A C   1 
ATOM   987  O O   . CYS A 1 127 ? 10.08102 1.97441   1.42839   1.000 20.44253 ? 128 CYS A O   1 
ATOM   988  C CB  . CYS A 1 127 ? 8.60068  1.63706   4.46052   1.000 18.73298 ? 128 CYS A CB  1 
ATOM   989  S SG  . CYS A 1 127 ? 8.60641  2.79122   5.79832   1.000 33.46353 ? 128 CYS A SG  1 
ATOM   990  N N   . ALA A 1 128 ? 10.48656 3.54165   3.00135   1.000 26.35996 ? 129 ALA A N   1 
ATOM   991  C CA  . ALA A 1 128 ? 11.83373 3.85802   2.53430   1.000 19.93368 ? 129 ALA A CA  1 
ATOM   992  C C   . ALA A 1 128 ? 12.78463 3.95922   3.72327   1.000 20.22049 ? 129 ALA A C   1 
ATOM   993  O O   . ALA A 1 128 ? 12.39369 4.33312   4.82889   1.000 22.47138 ? 129 ALA A O   1 
ATOM   994  C CB  . ALA A 1 128 ? 11.86013 5.16708   1.72339   1.000 20.95270 ? 129 ALA A CB  1 
ATOM   995  N N   . MET A 1 129 ? 14.04630 3.61871   3.48883   1.000 17.89147 ? 130 MET A N   1 
ATOM   996  C CA  . MET A 1 129 ? 15.07603 3.83710   4.48851   1.000 18.52874 ? 130 MET A CA  1 
ATOM   997  C C   . MET A 1 129 ? 15.51862 5.29705   4.40126   1.000 19.72249 ? 130 MET A C   1 
ATOM   998  O O   . MET A 1 129 ? 16.01442 5.73089   3.35891   1.000 21.63319 ? 130 MET A O   1 
ATOM   999  C CB  . MET A 1 129 ? 16.23867 2.87226   4.24509   1.000 19.01262 ? 130 MET A CB  1 
ATOM   1000 C CG  . MET A 1 129 ? 17.42529 2.99646   5.20938   1.000 22.07963 ? 130 MET A CG  1 
ATOM   1001 S SD  . MET A 1 129 ? 17.04535 2.51263   6.88649   1.000 26.51683 ? 130 MET A SD  1 
ATOM   1002 C CE  . MET A 1 129 ? 16.49702 0.80392   6.70438   1.000 18.10911 ? 130 MET A CE  1 
ATOM   1003 N N   . ARG A 1 130 ? 15.31666 6.05653   5.46838   1.000 19.50932 ? 131 ARG A N   1 
ATOM   1004 C CA  . ARG A 1 130 ? 15.67118 7.46970   5.43872   1.000 19.99733 ? 131 ARG A CA  1 
ATOM   1005 C C   . ARG A 1 130 ? 17.19341 7.63393   5.39679   1.000 19.90742 ? 131 ARG A C   1 
ATOM   1006 O O   . ARG A 1 130 ? 17.93605 6.73993   5.81117   1.000 20.59698 ? 131 ARG A O   1 
ATOM   1007 C CB  . ARG A 1 130 ? 15.10511 8.19991   6.65170   1.000 20.55257 ? 131 ARG A CB  1 
ATOM   1008 C CG  . ARG A 1 130 ? 13.57690 8.20120   6.78085   1.000 22.47421 ? 131 ARG A CG  1 
ATOM   1009 C CD  . ARG A 1 130 ? 12.86257 8.72721   5.55385   1.000 21.15357 ? 131 ARG A CD  1 
ATOM   1010 N NE  . ARG A 1 130 ? 13.36813 10.03564  5.13956   1.000 20.12992 ? 131 ARG A NE  1 
ATOM   1011 C CZ  . ARG A 1 130 ? 13.03679 10.63486  4.00153   1.000 25.70722 ? 131 ARG A CZ  1 
ATOM   1012 N NH1 . ARG A 1 130 ? 12.18686 10.05033  3.15636   1.000 21.69358 ? 131 ARG A NH1 1 
ATOM   1013 N NH2 . ARG A 1 130 ? 13.55911 11.81858  3.70199   1.000 23.04488 ? 131 ARG A NH2 1 
ATOM   1014 N N   . PRO A 1 131 ? 17.68876 8.76259   4.87446   1.000 19.41481 ? 132 PRO A N   1 
ATOM   1015 C CA  . PRO A 1 131 ? 19.13471 9.01356   4.93721   1.000 23.44490 ? 132 PRO A CA  1 
ATOM   1016 C C   . PRO A 1 131 ? 19.72811 8.89471   6.33663   1.000 21.80549 ? 132 PRO A C   1 
ATOM   1017 O O   . PRO A 1 131 ? 20.90842 8.52835   6.46499   1.000 24.06812 ? 132 PRO A O   1 
ATOM   1018 C CB  . PRO A 1 131 ? 19.25237 10.44015  4.38090   1.000 24.62473 ? 132 PRO A CB  1 
ATOM   1019 C CG  . PRO A 1 131 ? 18.13169 10.51436  3.37559   1.000 22.28741 ? 132 PRO A CG  1 
ATOM   1020 C CD  . PRO A 1 131 ? 16.99320 9.75417   4.02924   1.000 20.06858 ? 132 PRO A CD  1 
ATOM   1021 N N   . ASN A 1 132 ? 18.95510 9.16434   7.38920   1.000 20.89345 ? 133 ASN A N   1 
ATOM   1022 C CA  . ASN A 1 132 ? 19.44664 9.01826   8.75829   1.000 20.78753 ? 133 ASN A CA  1 
ATOM   1023 C C   . ASN A 1 132 ? 19.14052 7.64270   9.35114   1.000 21.09664 ? 133 ASN A C   1 
ATOM   1024 O O   . ASN A 1 132 ? 19.18282 7.48444   10.57624  1.000 20.53723 ? 133 ASN A O   1 
ATOM   1025 C CB  . ASN A 1 132 ? 18.88068 10.11777  9.65505   1.000 25.52474 ? 133 ASN A CB  1 
ATOM   1026 C CG  . ASN A 1 132 ? 17.40088 9.97958   9.89373   1.000 23.26212 ? 133 ASN A CG  1 
ATOM   1027 O OD1 . ASN A 1 132 ? 16.75366 9.08575   9.35952   1.000 22.56092 ? 133 ASN A OD1 1 
ATOM   1028 N ND2 . ASN A 1 132 ? 16.85414 10.87073  10.71379  1.000 23.75278 ? 133 ASN A ND2 1 
ATOM   1029 N N   . PHE A 1 133 ? 18.80452 6.67148   8.50263   1.000 19.96706 ? 134 PHE A N   1 
ATOM   1030 C CA  . PHE A 1 133 ? 18.65162 5.25173   8.84191   1.000 21.02021 ? 134 PHE A CA  1 
ATOM   1031 C C   . PHE A 1 133 ? 17.48341 4.97835   9.77407   1.000 20.15561 ? 134 PHE A C   1 
ATOM   1032 O O   . PHE A 1 133 ? 17.41891 3.91170   10.40582  1.000 22.08359 ? 134 PHE A O   1 
ATOM   1033 C CB  . PHE A 1 133 ? 19.94602 4.67290   9.41113   1.000 19.90561 ? 134 PHE A CB  1 
ATOM   1034 C CG  . PHE A 1 133 ? 21.04795 4.55432   8.38720   1.000 19.54837 ? 134 PHE A CG  1 
ATOM   1035 C CD1 . PHE A 1 133 ? 21.02963 3.54063   7.44601   1.000 21.54998 ? 134 PHE A CD1 1 
ATOM   1036 C CD2 . PHE A 1 133 ? 22.07642 5.48118   8.35088   1.000 25.01675 ? 134 PHE A CD2 1 
ATOM   1037 C CE1 . PHE A 1 133 ? 22.04584 3.42521   6.49961   1.000 24.66888 ? 134 PHE A CE1 1 
ATOM   1038 C CE2 . PHE A 1 133 ? 23.07783 5.39161   7.40444   1.000 25.50742 ? 134 PHE A CE2 1 
ATOM   1039 C CZ  . PHE A 1 133 ? 23.06726 4.35901   6.47907   1.000 29.34297 ? 134 PHE A CZ  1 
ATOM   1040 N N   . THR A 1 134 ? 16.55386 5.91694   9.87757   1.000 20.58565 ? 135 THR A N   1 
ATOM   1041 C CA  . THR A 1 134 ? 15.24209 5.62841   10.42465  1.000 19.44633 ? 135 THR A CA  1 
ATOM   1042 C C   . THR A 1 134 ? 14.31444 5.23476   9.28016   1.000 19.07231 ? 135 THR A C   1 
ATOM   1043 O O   . THR A 1 134 ? 14.62881 5.42240   8.10584   1.000 20.41332 ? 135 THR A O   1 
ATOM   1044 C CB  . THR A 1 134 ? 14.69439 6.83818   11.17514  1.000 18.99308 ? 135 THR A CB  1 
ATOM   1045 O OG1 . THR A 1 134 ? 14.49964 7.92162   10.25094  1.000 20.64467 ? 135 THR A OG1 1 
ATOM   1046 C CG2 . THR A 1 134 ? 15.68116 7.26854   12.26223  1.000 21.07138 ? 135 THR A CG2 1 
ATOM   1047 N N   . ILE A 1 135 ? 13.17404 4.64569   9.61906   1.000 19.89615 ? 136 ILE A N   1 
ATOM   1048 C CA  . ILE A 1 135 ? 12.09357 4.51076   8.65214   1.000 18.30801 ? 136 ILE A CA  1 
ATOM   1049 C C   . ILE A 1 135 ? 10.85449 5.16394   9.25452   1.000 22.19025 ? 136 ILE A C   1 
ATOM   1050 O O   . ILE A 1 135 ? 10.59073 5.04131   10.45722  1.000 21.46387 ? 136 ILE A O   1 
ATOM   1051 C CB  . ILE A 1 135 ? 11.83451 3.04144   8.23346   1.000 24.93029 ? 136 ILE A CB  1 
ATOM   1052 C CG1 . ILE A 1 135 ? 10.99039 2.29447   9.25425   1.000 22.33641 ? 136 ILE A CG1 1 
ATOM   1053 C CG2 . ILE A 1 135 ? 13.15513 2.29224   7.98672   1.000 24.65044 ? 136 ILE A CG2 1 
ATOM   1054 C CD1 . ILE A 1 135 ? 10.63135 0.87722   8.83119   1.000 24.18126 ? 136 ILE A CD1 1 
ATOM   1055 N N   . LYS A 1 136 ? 10.13181 5.92226   8.43054   1.000 21.44618 ? 137 LYS A N   1 
ATOM   1056 C CA  . LYS A 1 136 ? 8.88147  6.54246   8.86212   1.000 22.23014 ? 137 LYS A CA  1 
ATOM   1057 C C   . LYS A 1 136 ? 7.76319  5.55535   8.56447   1.000 25.00921 ? 137 LYS A C   1 
ATOM   1058 O O   . LYS A 1 136 ? 7.04757  5.64596   7.56638   1.000 26.41914 ? 137 LYS A O   1 
ATOM   1059 C CB  . LYS A 1 136 ? 8.67675  7.88586   8.16932   1.000 23.40831 ? 137 LYS A CB  1 
ATOM   1060 C CG  . LYS A 1 136 ? 9.62309  8.95228   8.68874   1.000 29.85883 ? 137 LYS A CG  1 
ATOM   1061 C CD  . LYS A 1 136 ? 9.53472  10.23976  7.87405   1.000 37.61712 ? 137 LYS A CD  1 
ATOM   1062 C CE  . LYS A 1 136 ? 10.76674 11.11384  8.10193   1.000 37.48272 ? 137 LYS A CE  1 
ATOM   1063 N NZ  . LYS A 1 136 ? 10.72145 12.31908  7.22813   1.000 41.10431 ? 137 LYS A NZ  1 
ATOM   1064 N N   . GLY A 1 137 ? 7.64397  4.56666   9.44276   1.000 22.82041 ? 138 GLY A N   1 
ATOM   1065 C CA  . GLY A 1 137 ? 6.69067  3.50005   9.25432   1.000 23.72781 ? 138 GLY A CA  1 
ATOM   1066 C C   . GLY A 1 137 ? 5.38004  3.75792   9.96690   1.000 20.15608 ? 138 GLY A C   1 
ATOM   1067 O O   . GLY A 1 137 ? 5.18310  4.77536   10.63338  1.000 23.44984 ? 138 GLY A O   1 
ATOM   1068 N N   . SER A 1 138 ? 4.47135  2.80082   9.80939   1.000 20.04194 ? 139 SER A N   1 
ATOM   1069 C CA  . SER A 1 138 ? 3.20494  2.77103   10.53606  1.000 23.07990 ? 139 SER A CA  1 
ATOM   1070 C C   . SER A 1 138 ? 3.20770  1.47672   11.34384  1.000 26.03949 ? 139 SER A C   1 
ATOM   1071 O O   . SER A 1 138 ? 2.88434  0.40224   10.82298  1.000 23.36347 ? 139 SER A O   1 
ATOM   1072 C CB  . SER A 1 138 ? 2.01603  2.84945   9.58092   1.000 26.77292 ? 139 SER A CB  1 
ATOM   1073 O OG  . SER A 1 138 ? 0.80471  2.81581   10.30694  1.000 26.99157 ? 139 SER A OG  1 
ATOM   1074 N N   . PHE A 1 139 ? 3.60920  1.58435   12.60508  1.000 23.40950 ? 140 PHE A N   1 
ATOM   1075 C CA  . PHE A 1 139 ? 3.81117  0.45240   13.49202  1.000 22.51496 ? 140 PHE A CA  1 
ATOM   1076 C C   . PHE A 1 139 ? 3.23541  0.81061   14.84856  1.000 23.90318 ? 140 PHE A C   1 
ATOM   1077 O O   . PHE A 1 139 ? 3.49265  1.90434   15.35792  1.000 24.14824 ? 140 PHE A O   1 
ATOM   1078 C CB  . PHE A 1 139 ? 5.29286  0.14281   13.69692  1.000 23.31005 ? 140 PHE A CB  1 
ATOM   1079 C CG  . PHE A 1 139 ? 6.00126  -0.44970  12.50933  1.000 19.77148 ? 140 PHE A CG  1 
ATOM   1080 C CD1 . PHE A 1 139 ? 5.63486  -1.67493  11.98907  1.000 21.21788 ? 140 PHE A CD1 1 
ATOM   1081 C CD2 . PHE A 1 139 ? 7.09633  0.20565   11.96203  1.000 19.54026 ? 140 PHE A CD2 1 
ATOM   1082 C CE1 . PHE A 1 139 ? 6.34673  -2.22883  10.95250  1.000 18.73740 ? 140 PHE A CE1 1 
ATOM   1083 C CE2 . PHE A 1 139 ? 7.80439  -0.34107  10.90941  1.000 22.28395 ? 140 PHE A CE2 1 
ATOM   1084 C CZ  . PHE A 1 139 ? 7.43654  -1.56168  10.41313  1.000 21.31835 ? 140 PHE A CZ  1 
ATOM   1085 N N   . LEU A 1 140 ? 2.48857  -0.11170  15.43784  1.000 22.36916 ? 141 LEU A N   1 
ATOM   1086 C CA  . LEU A 1 140 ? 1.97357  0.04565   16.78895  1.000 26.61075 ? 141 LEU A CA  1 
ATOM   1087 C C   . LEU A 1 140 ? 2.75923  -0.84686  17.74060  1.000 25.31175 ? 141 LEU A C   1 
ATOM   1088 O O   . LEU A 1 140 ? 3.62443  -1.62811  17.33574  1.000 22.92720 ? 141 LEU A O   1 
ATOM   1089 C CB  . LEU A 1 140 ? 0.48358  -0.29924  16.83950  1.000 26.14632 ? 141 LEU A CB  1 
ATOM   1090 C CG  . LEU A 1 140 ? -0.41848 0.45284   15.86208  1.000 24.64512 ? 141 LEU A CG  1 
ATOM   1091 C CD1 . LEU A 1 140 ? -1.80291 -0.13961  15.90620  1.000 28.74089 ? 141 LEU A CD1 1 
ATOM   1092 C CD2 . LEU A 1 140 ? -0.44785 1.94823   16.19213  1.000 29.16277 ? 141 LEU A CD2 1 
ATOM   1093 N N   . ASN A 1 141 ? 2.44809  -0.73503  19.02568  1.000 25.62466 ? 142 ASN A N   1 
ATOM   1094 C CA  . ASN A 1 141 ? 3.06175  -1.63346  19.99072  1.000 24.46930 ? 142 ASN A CA  1 
ATOM   1095 C C   . ASN A 1 141 ? 2.82601  -3.08517  19.60088  1.000 24.75407 ? 142 ASN A C   1 
ATOM   1096 O O   . ASN A 1 141 ? 1.74500  -3.45624  19.13568  1.000 26.53454 ? 142 ASN A O   1 
ATOM   1097 C CB  . ASN A 1 141 ? 2.52451  -1.36022  21.39186  1.000 28.30413 ? 142 ASN A CB  1 
ATOM   1098 C CG  . ASN A 1 141 ? 3.24545  -0.22675  22.05511  1.000 30.70585 ? 142 ASN A CG  1 
ATOM   1099 O OD1 . ASN A 1 141 ? 3.08737  0.92792   21.67261  1.000 32.94826 ? 142 ASN A OD1 1 
ATOM   1100 N ND2 . ASN A 1 141 ? 4.05826  -0.54635  23.05431  1.000 34.35165 ? 142 ASN A ND2 1 
ATOM   1101 N N   . GLY A 1 142 ? 3.86012  -3.90641  19.77052  1.000 21.06238 ? 143 GLY A N   1 
ATOM   1102 C CA  . GLY A 1 142 ? 3.78114  -5.30075  19.40618  1.000 22.10411 ? 143 GLY A CA  1 
ATOM   1103 C C   . GLY A 1 142 ? 4.05999  -5.60916  17.94919  1.000 19.28153 ? 143 GLY A C   1 
ATOM   1104 O O   . GLY A 1 142 ? 3.98277  -6.77993  17.55589  1.000 20.05177 ? 143 GLY A O   1 
ATOM   1105 N N   . SER A 1 143 ? 4.37372  -4.60082  17.14168  1.000 20.95646 ? 144 SER A N   1 
ATOM   1106 C CA  . SER A 1 143 ? 4.72451  -4.80506  15.74465  1.000 21.73550 ? 144 SER A CA  1 
ATOM   1107 C C   . SER A 1 143 ? 6.15185  -5.28947  15.57104  1.000 19.43135 ? 144 SER A C   1 
ATOM   1108 O O   . SER A 1 143 ? 6.51073  -5.70820  14.46670  1.000 17.66993 ? 144 SER A O   1 
ATOM   1109 C CB  . SER A 1 143 ? 4.51739  -3.50591  14.96612  1.000 20.95997 ? 144 SER A CB  1 
ATOM   1110 O OG  . SER A 1 143 ? 5.35017  -2.49211  15.51425  1.000 21.18440 ? 144 SER A OG  1 
ATOM   1111 N N   . CYS A 1 144 ? 6.96286  -5.27203  16.63723  1.000 18.11438 ? 145 CYS A N   1 
ATOM   1112 C CA  . CYS A 1 144 ? 8.33766  -5.75890  16.55324  1.000 19.19770 ? 145 CYS A CA  1 
ATOM   1113 C C   . CYS A 1 144 ? 8.40457  -7.13661  15.91000  1.000 17.48514 ? 145 CYS A C   1 
ATOM   1114 O O   . CYS A 1 144 ? 7.57879  -8.00714  16.17943  1.000 17.24758 ? 145 CYS A O   1 
ATOM   1115 C CB  . CYS A 1 144 ? 8.94888  -5.80879  17.95256  1.000 16.30484 ? 145 CYS A CB  1 
ATOM   1116 S SG  . CYS A 1 144 ? 8.59389  -4.34355  18.88114  1.000 21.27220 ? 145 CYS A SG  1 
ATOM   1117 N N   . GLY A 1 145 ? 9.41375  -7.34784  15.06224  1.000 16.16957 ? 146 GLY A N   1 
ATOM   1118 C CA  . GLY A 1 145 ? 9.54446  -8.59171  14.34937  1.000 15.74019 ? 146 GLY A CA  1 
ATOM   1119 C C   . GLY A 1 145 ? 8.90321  -8.58824  12.97721  1.000 15.37895 ? 146 GLY A C   1 
ATOM   1120 O O   . GLY A 1 145 ? 9.15506  -9.51095  12.19460  1.000 18.07780 ? 146 GLY A O   1 
ATOM   1121 N N   . SER A 1 146 ? 8.05566  -7.59565  12.67902  1.000 16.79886 ? 147 SER A N   1 
ATOM   1122 C CA  . SER A 1 146 ? 7.56703  -7.40975  11.31538  1.000 17.77973 ? 147 SER A CA  1 
ATOM   1123 C C   . SER A 1 146 ? 8.74685  -7.11544  10.39865  1.000 16.31758 ? 147 SER A C   1 
ATOM   1124 O O   . SER A 1 146 ? 9.73700  -6.51340  10.81686  1.000 15.63108 ? 147 SER A O   1 
ATOM   1125 C CB  . SER A 1 146 ? 6.57380  -6.24309  11.24629  1.000 16.69741 ? 147 SER A CB  1 
ATOM   1126 O OG  . SER A 1 146 ? 5.38232  -6.48313  11.98373  1.000 20.06864 ? 147 SER A OG  1 
ATOM   1127 N N   . VAL A 1 147 ? 8.63814  -7.51965  9.12744   1.000 14.95179 ? 148 VAL A N   1 
ATOM   1128 C CA  . VAL A 1 147 ? 9.79914  -7.42807  8.24508   1.000 15.79570 ? 148 VAL A CA  1 
ATOM   1129 C C   . VAL A 1 147 ? 9.48432  -6.58707  7.02015   1.000 16.60039 ? 148 VAL A C   1 
ATOM   1130 O O   . VAL A 1 147 ? 8.32969  -6.47099  6.59873   1.000 16.69202 ? 148 VAL A O   1 
ATOM   1131 C CB  . VAL A 1 147 ? 10.33804 -8.80791  7.81136   1.000 17.70424 ? 148 VAL A CB  1 
ATOM   1132 C CG1 . VAL A 1 147 ? 10.85351 -9.57384  9.02069   1.000 18.52354 ? 148 VAL A CG1 1 
ATOM   1133 C CG2 . VAL A 1 147 ? 9.26918  -9.61706  7.05570   1.000 15.85428 ? 148 VAL A CG2 1 
ATOM   1134 N N   . GLY A 1 148 ? 10.53708 -5.96649  6.48506   1.000 16.44640 ? 149 GLY A N   1 
ATOM   1135 C CA  . GLY A 1 148 ? 10.50555 -5.30714  5.19572   1.000 13.82217 ? 149 GLY A CA  1 
ATOM   1136 C C   . GLY A 1 148 ? 11.21942 -6.16368  4.16493   1.000 16.22096 ? 149 GLY A C   1 
ATOM   1137 O O   . GLY A 1 148 ? 12.15620 -6.89119  4.47877   1.000 15.33982 ? 149 GLY A O   1 
ATOM   1138 N N   . PHE A 1 149 ? 10.76534 -6.08070  2.92355   1.000 16.50508 ? 150 PHE A N   1 
ATOM   1139 C CA  . PHE A 1 149 ? 11.25040 -7.01611  1.92162   1.000 17.36072 ? 150 PHE A CA  1 
ATOM   1140 C C   . PHE A 1 149 ? 11.04282 -6.42660  0.54182   1.000 18.90059 ? 150 PHE A C   1 
ATOM   1141 O O   . PHE A 1 149 ? 10.22655 -5.52875  0.34371   1.000 16.48744 ? 150 PHE A O   1 
ATOM   1142 C CB  . PHE A 1 149 ? 10.51514 -8.35368  2.00718   1.000 17.34548 ? 150 PHE A CB  1 
ATOM   1143 C CG  . PHE A 1 149 ? 9.04496  -8.23447  1.79825   1.000 17.87707 ? 150 PHE A CG  1 
ATOM   1144 C CD1 . PHE A 1 149 ? 8.20478  -7.89707  2.84890   1.000 18.68688 ? 150 PHE A CD1 1 
ATOM   1145 C CD2 . PHE A 1 149 ? 8.49595  -8.44275  0.53955   1.000 20.31869 ? 150 PHE A CD2 1 
ATOM   1146 C CE1 . PHE A 1 149 ? 6.83155  -7.77491  2.64046   1.000 20.51609 ? 150 PHE A CE1 1 
ATOM   1147 C CE2 . PHE A 1 149 ? 7.12870  -8.32072  0.32508   1.000 22.89315 ? 150 PHE A CE2 1 
ATOM   1148 C CZ  . PHE A 1 149 ? 6.29515  -7.99988  1.38381   1.000 19.96058 ? 150 PHE A CZ  1 
ATOM   1149 N N   . ASN A 1 150 ? 11.77187 -6.97897  -0.41225  1.000 17.26500 ? 151 ASN A N   1 
ATOM   1150 C CA  . ASN A 1 150 ? 11.51064 -6.77694  -1.82738  1.000 19.49319 ? 151 ASN A CA  1 
ATOM   1151 C C   . ASN A 1 150 ? 11.36918 -8.14166  -2.48103  1.000 21.66203 ? 151 ASN A C   1 
ATOM   1152 O O   . ASN A 1 150 ? 11.87762 -9.14289  -1.97236  1.000 22.00226 ? 151 ASN A O   1 
ATOM   1153 C CB  . ASN A 1 150 ? 12.63233 -5.98537  -2.49183  1.000 20.27032 ? 151 ASN A CB  1 
ATOM   1154 C CG  . ASN A 1 150 ? 12.57831 -4.51542  -2.15589  1.000 23.23288 ? 151 ASN A CG  1 
ATOM   1155 O OD1 . ASN A 1 150 ? 11.78754 -3.77030  -2.73503  1.000 25.60249 ? 151 ASN A OD1 1 
ATOM   1156 N ND2 . ASN A 1 150 ? 13.41390 -4.08612  -1.20562  1.000 17.22199 ? 151 ASN A ND2 1 
ATOM   1157 N N   . ILE A 1 151 ? 10.65849 -8.19343  -3.60404  1.000 21.65441 ? 152 ILE A N   1 
ATOM   1158 C CA  . ILE A 1 151 ? 10.48241 -9.44296  -4.32641  1.000 25.39787 ? 152 ILE A CA  1 
ATOM   1159 C C   . ILE A 1 151 ? 11.10637 -9.29857  -5.70191  1.000 35.28016 ? 152 ILE A C   1 
ATOM   1160 O O   . ILE A 1 151 ? 10.82856 -8.32789  -6.41562  1.000 34.38049 ? 152 ILE A O   1 
ATOM   1161 C CB  . ILE A 1 151 ? 9.00752  -9.85849  -4.41033  1.000 24.08674 ? 152 ILE A CB  1 
ATOM   1162 C CG1 . ILE A 1 151 ? 8.51597  -10.16960 -2.99237  1.000 26.83763 ? 152 ILE A CG1 1 
ATOM   1163 C CG2 . ILE A 1 151 ? 8.87016  -11.11036 -5.26260  1.000 32.05317 ? 152 ILE A CG2 1 
ATOM   1164 C CD1 . ILE A 1 151 ? 7.05305  -10.49213 -2.88980  1.000 30.02853 ? 152 ILE A CD1 1 
ATOM   1165 N N   . ASP A 1 152 ? 11.98904 -10.24366 -6.04408  1.000 33.10134 ? 153 ASP A N   1 
ATOM   1166 C CA  . ASP A 1 152 ? 12.61432 -10.34592 -7.36201  1.000 40.49537 ? 153 ASP A CA  1 
ATOM   1167 C C   . ASP A 1 152 ? 12.12260 -11.65179 -7.97970  1.000 42.13958 ? 153 ASP A C   1 
ATOM   1168 O O   . ASP A 1 152 ? 12.61163 -12.73702 -7.64525  1.000 43.41623 ? 153 ASP A O   1 
ATOM   1169 C CB  . ASP A 1 152 ? 14.13586 -10.30083 -7.26122  1.000 43.99682 ? 153 ASP A CB  1 
ATOM   1170 C CG  . ASP A 1 152 ? 14.81261 -10.33379 -8.62246  1.000 51.19397 ? 153 ASP A CG  1 
ATOM   1171 O OD1 . ASP A 1 152 ? 14.09577 -10.34343 -9.65204  1.000 51.73408 ? 153 ASP A OD1 1 
ATOM   1172 O OD2 . ASP A 1 152 ? 16.06334 -10.34559 -8.66122  1.000 56.02115 ? 153 ASP A OD2 1 
ATOM   1173 N N   . TYR A 1 153 ? 11.14802 -11.53017 -8.87870  1.000 45.36489 ? 154 TYR A N   1 
ATOM   1174 C CA  . TYR A 1 153 ? 10.42315 -12.66020 -9.44526  1.000 41.93297 ? 154 TYR A CA  1 
ATOM   1175 C C   . TYR A 1 153 ? 9.90908  -13.61290 -8.37360  1.000 44.03003 ? 154 TYR A C   1 
ATOM   1176 O O   . TYR A 1 153 ? 8.81284  -13.42600 -7.83243  1.000 41.68906 ? 154 TYR A O   1 
ATOM   1177 C CB  . TYR A 1 153 ? 11.28776 -13.43990 -10.44003 1.000 46.67756 ? 154 TYR A CB  1 
ATOM   1178 C CG  . TYR A 1 153 ? 10.49776 -14.57444 -11.05497 1.000 52.31069 ? 154 TYR A CG  1 
ATOM   1179 C CD1 . TYR A 1 153 ? 9.24521  -14.33706 -11.61648 1.000 53.56851 ? 154 TYR A CD1 1 
ATOM   1180 C CD2 . TYR A 1 153 ? 10.96869 -15.88135 -11.02841 1.000 49.36198 ? 154 TYR A CD2 1 
ATOM   1181 C CE1 . TYR A 1 153 ? 8.49785  -15.36122 -12.15989 1.000 54.39877 ? 154 TYR A CE1 1 
ATOM   1182 C CE2 . TYR A 1 153 ? 10.22358 -16.91547 -11.56983 1.000 53.31533 ? 154 TYR A CE2 1 
ATOM   1183 C CZ  . TYR A 1 153 ? 8.98883  -16.64661 -12.13535 1.000 54.58550 ? 154 TYR A CZ  1 
ATOM   1184 O OH  . TYR A 1 153 ? 8.23819  -17.66104 -12.67988 1.000 62.88510 ? 154 TYR A OH  1 
ATOM   1185 N N   . ASP A 1 154 ? 10.69277 -14.64993 -8.08074  1.000 40.82861 ? 155 ASP A N   1 
ATOM   1186 C CA  . ASP A 1 154 ? 10.29769 -15.68800 -7.14351  1.000 43.58154 ? 155 ASP A CA  1 
ATOM   1187 C C   . ASP A 1 154 ? 10.98604 -15.55251 -5.79643  1.000 33.64558 ? 155 ASP A C   1 
ATOM   1188 O O   . ASP A 1 154 ? 10.58450 -16.23001 -4.84210  1.000 36.49189 ? 155 ASP A O   1 
ATOM   1189 C CB  . ASP A 1 154 ? 10.60234 -17.07654 -7.73521  1.000 41.43690 ? 155 ASP A CB  1 
ATOM   1190 C CG  . ASP A 1 154 ? 12.07159 -17.23853 -8.13223  1.000 43.08029 ? 155 ASP A CG  1 
ATOM   1191 O OD1 . ASP A 1 154 ? 12.77744 -16.22035 -8.25746  1.000 45.48672 ? 155 ASP A OD1 1 
ATOM   1192 O OD2 . ASP A 1 154 ? 12.52298 -18.38699 -8.31999  1.000 49.60330 ? 155 ASP A OD2 1 
ATOM   1193 N N   . CYS A 1 155 ? 11.98997 -14.68830 -5.70264  1.000 33.27554 ? 156 CYS A N   1 
ATOM   1194 C CA  . CYS A 1 155 ? 12.88575 -14.61839 -4.55794  1.000 31.46588 ? 156 CYS A CA  1 
ATOM   1195 C C   . CYS A 1 155 ? 12.52468 -13.43761 -3.66308  1.000 30.83021 ? 156 CYS A C   1 
ATOM   1196 O O   . CYS A 1 155 ? 12.44545 -12.29537 -4.12727  1.000 28.49551 ? 156 CYS A O   1 
ATOM   1197 C CB  . CYS A 1 155 ? 14.33251 -14.48780 -5.03163  1.000 35.31867 ? 156 CYS A CB  1 
ATOM   1198 S SG  . CYS A 1 155 ? 15.57869 -14.59731 -3.72873  1.000 40.32926 ? 156 CYS A SG  1 
ATOM   1199 N N   . VAL A 1 156 ? 12.34128 -13.71083 -2.37770  1.000 28.40310 ? 157 VAL A N   1 
ATOM   1200 C CA  . VAL A 1 156 ? 12.08337 -12.66928 -1.38790  1.000 24.37340 ? 157 VAL A CA  1 
ATOM   1201 C C   . VAL A 1 156 ? 13.41091 -12.20140 -0.80615  1.000 26.26194 ? 157 VAL A C   1 
ATOM   1202 O O   . VAL A 1 156 ? 14.13826 -12.98961 -0.19929  1.000 25.41033 ? 157 VAL A O   1 
ATOM   1203 C CB  . VAL A 1 156 ? 11.16068 -13.18886 -0.27716  1.000 25.81882 ? 157 VAL A CB  1 
ATOM   1204 C CG1 . VAL A 1 156 ? 10.83619 -12.06814 0.71186   1.000 22.08862 ? 157 VAL A CG1 1 
ATOM   1205 C CG2 . VAL A 1 156 ? 9.90390  -13.78444 -0.88294  1.000 25.52040 ? 157 VAL A CG2 1 
ATOM   1206 N N   . SER A 1 157 ? 13.72251 -10.91667 -0.95559  1.000 23.15189 ? 158 SER A N   1 
ATOM   1207 C CA  . SER A 1 157 ? 14.90029 -10.32678 -0.31320  1.000 20.53169 ? 158 SER A CA  1 
ATOM   1208 C C   . SER A 1 157 ? 14.44528 -9.57836  0.93057   1.000 22.35496 ? 158 SER A C   1 
ATOM   1209 O O   . SER A 1 157 ? 13.88805 -8.48150  0.84071   1.000 18.52068 ? 158 SER A O   1 
ATOM   1210 C CB  . SER A 1 157 ? 15.64463 -9.39932  -1.26262  1.000 24.13541 ? 158 SER A CB  1 
ATOM   1211 O OG  . SER A 1 157 ? 16.25995 -10.14329 -2.30494  1.000 31.72831 ? 158 SER A OG  1 
ATOM   1212 N N   . PHE A 1 158 ? 14.68993 -10.17120 2.08934   1.000 20.93983 ? 159 PHE A N   1 
ATOM   1213 C CA  . PHE A 1 158 ? 14.39813 -9.51720  3.35287   1.000 18.03775 ? 159 PHE A CA  1 
ATOM   1214 C C   . PHE A 1 158 ? 15.49561 -8.51538  3.68672   1.000 19.78565 ? 159 PHE A C   1 
ATOM   1215 O O   . PHE A 1 158 ? 16.68365 -8.85841  3.67304   1.000 18.49230 ? 159 PHE A O   1 
ATOM   1216 C CB  . PHE A 1 158 ? 14.31482 -10.55572 4.46205   1.000 17.99127 ? 159 PHE A CB  1 
ATOM   1217 C CG  . PHE A 1 158 ? 13.22864 -11.56291 4.28302   1.000 17.79048 ? 159 PHE A CG  1 
ATOM   1218 C CD1 . PHE A 1 158 ? 11.91261 -11.24086 4.57141   1.000 18.40229 ? 159 PHE A CD1 1 
ATOM   1219 C CD2 . PHE A 1 158 ? 13.53021 -12.85408 3.88574   1.000 21.47735 ? 159 PHE A CD2 1 
ATOM   1220 C CE1 . PHE A 1 158 ? 10.89692 -12.18005 4.43626   1.000 20.66339 ? 159 PHE A CE1 1 
ATOM   1221 C CE2 . PHE A 1 158 ? 12.52883 -13.81037 3.75658   1.000 19.99507 ? 159 PHE A CE2 1 
ATOM   1222 C CZ  . PHE A 1 158 ? 11.21317 -13.47880 4.03059   1.000 20.19389 ? 159 PHE A CZ  1 
ATOM   1223 N N   . CYS A 1 159 ? 15.10090 -7.28383  4.02821   1.000 16.19970 ? 160 CYS A N   1 
ATOM   1224 C CA  . CYS A 1 159 ? 16.06621 -6.23273  4.29718   1.000 17.77122 ? 160 CYS A CA  1 
ATOM   1225 C C   . CYS A 1 159 ? 15.85932 -5.51962  5.62478   1.000 16.80594 ? 160 CYS A C   1 
ATOM   1226 O O   . CYS A 1 159 ? 16.75083 -4.78283  6.04885   1.000 18.16815 ? 160 CYS A O   1 
ATOM   1227 C CB  . CYS A 1 159 ? 16.04222 -5.18432  3.18095   1.000 18.83064 ? 160 CYS A CB  1 
ATOM   1228 S SG  . CYS A 1 159 ? 14.41472 -4.42053  2.94142   1.000 20.95082 ? 160 CYS A SG  1 
ATOM   1229 N N   . TYR A 1 160 ? 14.73841 -5.72411  6.29975   1.000 16.35486 ? 161 TYR A N   1 
ATOM   1230 C CA  . TYR A 1 160 ? 14.47938 -4.98514  7.51950   1.000 15.73526 ? 161 TYR A CA  1 
ATOM   1231 C C   . TYR A 1 160 ? 13.70313 -5.86760  8.47999   1.000 14.13093 ? 161 TYR A C   1 
ATOM   1232 O O   . TYR A 1 160 ? 12.78938 -6.57114  8.07154   1.000 14.38274 ? 161 TYR A O   1 
ATOM   1233 C CB  . TYR A 1 160 ? 13.67530 -3.71754  7.19994   1.000 15.38189 ? 161 TYR A CB  1 
ATOM   1234 C CG  . TYR A 1 160 ? 13.29901 -2.90567  8.40663   1.000 12.81811 ? 161 TYR A CG  1 
ATOM   1235 C CD1 . TYR A 1 160 ? 14.22804 -2.07981  9.01723   1.000 16.95515 ? 161 TYR A CD1 1 
ATOM   1236 C CD2 . TYR A 1 160 ? 12.00336 -2.94062  8.91982   1.000 14.33382 ? 161 TYR A CD2 1 
ATOM   1237 C CE1 . TYR A 1 160 ? 13.89246 -1.31242  10.11414  1.000 15.10209 ? 161 TYR A CE1 1 
ATOM   1238 C CE2 . TYR A 1 160 ? 11.65251 -2.16019  10.02688  1.000 14.20684 ? 161 TYR A CE2 1 
ATOM   1239 C CZ  . TYR A 1 160 ? 12.61774 -1.36485  10.62605  1.000 15.37239 ? 161 TYR A CZ  1 
ATOM   1240 O OH  . TYR A 1 160 ? 12.34159 -0.58925  11.73325  1.000 15.82621 ? 161 TYR A OH  1 
ATOM   1241 N N   . MET A 1 161 ? 14.09044 -5.85748  9.74999   1.000 14.66539 ? 162 MET A N   1 
ATOM   1242 C CA  . MET A 1 161 ? 13.23560 -6.39606  10.79606  1.000 12.48240 ? 162 MET A CA  1 
ATOM   1243 C C   . MET A 1 161 ? 12.97518 -5.26663  11.78054  1.000 13.33019 ? 162 MET A C   1 
ATOM   1244 O O   . MET A 1 161 ? 13.91423 -4.59578  12.21335  1.000 15.33196 ? 162 MET A O   1 
ATOM   1245 C CB  . MET A 1 161 ? 13.87810 -7.60141  11.50564  1.000 14.91670 ? 162 MET A CB  1 
ATOM   1246 C CG  . MET A 1 161 ? 13.01395 -8.03977  12.66773  1.000 17.53355 ? 162 MET A CG  1 
ATOM   1247 S SD  . MET A 1 161 ? 13.46387 -9.61719  13.39732  1.000 20.99079 ? 162 MET A SD  1 
ATOM   1248 C CE  . MET A 1 161 ? 12.45750 -10.71708 12.38041  1.000 22.04557 ? 162 MET A CE  1 
ATOM   1249 N N   . HIS A 1 162 ? 11.70937 -5.03462  12.11133  1.000 14.89986 ? 163 HIS A N   1 
ATOM   1250 C CA  . HIS A 1 162 ? 11.36524 -3.89245  12.93503  1.000 12.66105 ? 163 HIS A CA  1 
ATOM   1251 C C   . HIS A 1 162 ? 11.69726 -4.17269  14.40422  1.000 13.41274 ? 163 HIS A C   1 
ATOM   1252 O O   . HIS A 1 162 ? 11.31208 -5.21960  14.93771  1.000 16.09499 ? 163 HIS A O   1 
ATOM   1253 C CB  . HIS A 1 162 ? 9.89091  -3.56978  12.80178  1.000 16.68928 ? 163 HIS A CB  1 
ATOM   1254 C CG  . HIS A 1 162 ? 9.46534  -2.47667  13.70342  1.000 16.67821 ? 163 HIS A CG  1 
ATOM   1255 N ND1 . HIS A 1 162 ? 10.07464 -1.24139  13.69523  1.000 14.25322 ? 163 HIS A ND1 1 
ATOM   1256 C CD2 . HIS A 1 162 ? 8.54191  -2.44388  14.69191  1.000 14.50825 ? 163 HIS A CD2 1 
ATOM   1257 C CE1 . HIS A 1 162 ? 9.51091  -0.47884  14.61475  1.000 15.94007 ? 163 HIS A CE1 1 
ATOM   1258 N NE2 . HIS A 1 162 ? 8.57655  -1.18643  15.22709  1.000 14.95293 ? 163 HIS A NE2 1 
ATOM   1259 N N   . HIS A 1 163 ? 12.37694 -3.23252  15.06159  1.000 13.59999 ? 164 HIS A N   1 
ATOM   1260 C CA  . HIS A 1 163 ? 12.69641 -3.38261  16.48733  1.000 15.53411 ? 164 HIS A CA  1 
ATOM   1261 C C   . HIS A 1 163 ? 11.98859 -2.39328  17.40460  1.000 18.20122 ? 164 HIS A C   1 
ATOM   1262 O O   . HIS A 1 163 ? 11.45028 -2.81137  18.43417  1.000 20.44070 ? 164 HIS A O   1 
ATOM   1263 C CB  . HIS A 1 163 ? 14.21014 -3.29161  16.73144  1.000 17.05774 ? 164 HIS A CB  1 
ATOM   1264 C CG  . HIS A 1 163 ? 14.94806 -4.53184  16.33744  1.000 15.82518 ? 164 HIS A CG  1 
ATOM   1265 N ND1 . HIS A 1 163 ? 15.64364 -5.31415  17.23718  1.000 16.63579 ? 164 HIS A ND1 1 
ATOM   1266 C CD2 . HIS A 1 163 ? 15.08175 -5.13399  15.13039  1.000 15.25168 ? 164 HIS A CD2 1 
ATOM   1267 C CE1 . HIS A 1 163 ? 16.18787 -6.33398  16.59752  1.000 14.98250 ? 164 HIS A CE1 1 
ATOM   1268 N NE2 . HIS A 1 163 ? 15.86855 -6.24410  15.31862  1.000 17.61604 ? 164 HIS A NE2 1 
ATOM   1269 N N   . MET A 1 164 ? 11.98433 -1.09686  17.10669  1.000 17.65449 ? 165 MET A N   1 
ATOM   1270 C CA  . MET A 1 164 ? 11.47904 -0.15646  18.10254  1.000 17.73648 ? 165 MET A CA  1 
ATOM   1271 C C   . MET A 1 164 ? 11.10151 1.17601   17.47360  1.000 19.24151 ? 165 MET A C   1 
ATOM   1272 O O   . MET A 1 164 ? 11.47140 1.50040   16.34371  1.000 17.03235 ? 165 MET A O   1 
ATOM   1273 C CB  . MET A 1 164 ? 12.52452 0.07943   19.19807  1.000 20.78463 ? 165 MET A CB  1 
ATOM   1274 C CG  . MET A 1 164 ? 13.75967 0.73082   18.64899  1.000 19.09500 ? 165 MET A CG  1 
ATOM   1275 S SD  . MET A 1 164 ? 15.19924 0.54582   19.71855  1.000 27.51460 ? 165 MET A SD  1 
ATOM   1276 C CE  . MET A 1 164 ? 16.28096 1.74041   18.94969  1.000 26.77449 ? 165 MET A CE  1 
ATOM   1277 N N   . GLU A 1 165 ? 10.37023 1.95671   18.25788  1.000 21.93896 ? 166 GLU A N   1 
ATOM   1278 C CA  . GLU A 1 165 ? 9.98651  3.31220   17.92399  1.000 19.79007 ? 166 GLU A CA  1 
ATOM   1279 C C   . GLU A 1 165 ? 10.89803 4.28933   18.65860  1.000 25.42810 ? 166 GLU A C   1 
ATOM   1280 O O   . GLU A 1 165 ? 11.21046 4.09593   19.83325  1.000 26.74297 ? 166 GLU A O   1 
ATOM   1281 C CB  . GLU A 1 165 ? 8.52636  3.54305   18.31498  1.000 24.54772 ? 166 GLU A CB  1 
ATOM   1282 C CG  . GLU A 1 165 ? 7.96404  4.90035   17.93381  1.000 28.24965 ? 166 GLU A CG  1 
ATOM   1283 C CD  . GLU A 1 165 ? 6.44820  4.89440   17.95817  1.000 34.29152 ? 166 GLU A CD  1 
ATOM   1284 O OE1 . GLU A 1 165 ? 5.86863  5.43418   18.92348  1.000 40.72995 ? 166 GLU A OE1 1 
ATOM   1285 O OE2 . GLU A 1 165 ? 5.83611  4.31227   17.02605  1.000 31.37720 ? 166 GLU A OE2 1 
ATOM   1286 N N   . LEU A 1 166 ? 11.33709 5.26479   17.97802  1.000 26.51810 ? 167 LEU A N   1 
ATOM   1287 C CA  . LEU A 1 166 ? 12.05458 6.29721   18.69790  1.000 33.18254 ? 167 LEU A CA  1 
ATOM   1288 C C   . LEU A 1 166 ? 11.06404 7.35700   19.17273  1.000 39.80137 ? 167 LEU A C   1 
ATOM   1289 O O   . LEU A 1 166 ? 10.07055 7.63358   18.48615  1.000 37.63466 ? 167 LEU A O   1 
ATOM   1290 C CB  . LEU A 1 166 ? 13.11891 6.92278   17.80207  1.000 32.16619 ? 167 LEU A CB  1 
ATOM   1291 C CG  . LEU A 1 166 ? 14.04571 5.94390   17.07569  1.000 28.99326 ? 167 LEU A CG  1 
ATOM   1292 C CD1 . LEU A 1 166 ? 14.88339 6.63190   15.99654  1.000 30.69229 ? 167 LEU A CD1 1 
ATOM   1293 C CD2 . LEU A 1 166 ? 14.94998 5.22080   18.07919  1.000 29.83281 ? 167 LEU A CD2 1 
ATOM   1294 N N   . PRO A 1 167 ? 11.31462 7.97718   20.35058  1.000 44.73421 ? 168 PRO A N   1 
ATOM   1295 C CA  . PRO A 1 167 ? 10.29777 8.84449   20.97649  1.000 43.00769 ? 168 PRO A CA  1 
ATOM   1296 C C   . PRO A 1 167 ? 9.74884  9.93183   20.06022  1.000 44.67068 ? 168 PRO A C   1 
ATOM   1297 O O   . PRO A 1 167 ? 8.71129  10.53536  20.35297  1.000 44.72211 ? 168 PRO A O   1 
ATOM   1298 C CB  . PRO A 1 167 ? 11.04839 9.46016   22.16374  1.000 45.86571 ? 168 PRO A CB  1 
ATOM   1299 C CG  . PRO A 1 167 ? 12.50515 9.34077   21.79926  1.000 48.88043 ? 168 PRO A CG  1 
ATOM   1300 C CD  . PRO A 1 167 ? 12.60036 8.03837   21.06621  1.000 44.01178 ? 168 PRO A CD  1 
ATOM   1301 N N   . THR A 1 168 ? 10.43997 10.18700  18.95203  1.000 40.78779 ? 169 THR A N   1 
ATOM   1302 C CA  . THR A 1 168 ? 9.97963  11.11458  17.93016  1.000 39.78576 ? 169 THR A CA  1 
ATOM   1303 C C   . THR A 1 168 ? 8.99051  10.49536  16.94960  1.000 40.44464 ? 169 THR A C   1 
ATOM   1304 O O   . THR A 1 168 ? 8.55456  11.18583  16.02158  1.000 43.76550 ? 169 THR A O   1 
ATOM   1305 C CB  . THR A 1 168 ? 11.17478 11.64624  17.15617  1.000 42.92001 ? 169 THR A CB  1 
ATOM   1306 O OG1 . THR A 1 168 ? 11.79624 10.55413  16.47320  1.000 42.78341 ? 169 THR A OG1 1 
ATOM   1307 C CG2 . THR A 1 168 ? 12.18315 12.27851  18.10183  1.000 41.51953 ? 169 THR A CG2 1 
ATOM   1308 N N   . GLY A 1 169 ? 8.65124  9.21693   17.09801  1.000 34.89801 ? 170 GLY A N   1 
ATOM   1309 C CA  . GLY A 1 169 ? 7.65512  8.58819   16.25585  1.000 34.53907 ? 170 GLY A CA  1 
ATOM   1310 C C   . GLY A 1 169 ? 8.18217  7.84417   15.04313  1.000 32.66237 ? 170 GLY A C   1 
ATOM   1311 O O   . GLY A 1 169 ? 7.40537  7.13125   14.39174  1.000 33.07251 ? 170 GLY A O   1 
ATOM   1312 N N   . VAL A 1 170 ? 9.46259  7.98934   14.70584  1.000 29.30276 ? 171 VAL A N   1 
ATOM   1313 C CA  . VAL A 1 170 ? 10.04323 7.21062   13.62098  1.000 26.32207 ? 171 VAL A CA  1 
ATOM   1314 C C   . VAL A 1 170 ? 10.55876 5.89873   14.19491  1.000 23.15029 ? 171 VAL A C   1 
ATOM   1315 O O   . VAL A 1 170 ? 10.54495 5.68480   15.41018  1.000 22.90083 ? 171 VAL A O   1 
ATOM   1316 C CB  . VAL A 1 170 ? 11.16886 7.96541   12.89532  1.000 27.01898 ? 171 VAL A CB  1 
ATOM   1317 C CG1 . VAL A 1 170 ? 10.60330 9.15894   12.12216  1.000 28.91231 ? 171 VAL A CG1 1 
ATOM   1318 C CG2 . VAL A 1 170 ? 12.23869 8.39052   13.89137  1.000 25.80839 ? 171 VAL A CG2 1 
ATOM   1319 N N   . HIS A 1 171 ? 11.04329 5.02573   13.32782  1.000 20.31938 ? 172 HIS A N   1 
ATOM   1320 C CA  . HIS A 1 171 ? 11.25925 3.63707   13.69859  1.000 20.69131 ? 172 HIS A CA  1 
ATOM   1321 C C   . HIS A 1 171 ? 12.67542 3.20584   13.35087  1.000 18.34339 ? 172 HIS A C   1 
ATOM   1322 O O   . HIS A 1 171 ? 13.33797 3.80416   12.50107  1.000 20.96991 ? 172 HIS A O   1 
ATOM   1323 C CB  . HIS A 1 171 ? 10.21512 2.75925   13.01916  1.000 18.07418 ? 172 HIS A CB  1 
ATOM   1324 C CG  . HIS A 1 171 ? 8.82442  3.08944   13.43975  1.000 18.90022 ? 172 HIS A CG  1 
ATOM   1325 N ND1 . HIS A 1 171 ? 7.94659  3.77939   12.62906  1.000 21.86534 ? 172 HIS A ND1 1 
ATOM   1326 C CD2 . HIS A 1 171 ? 8.17643  2.87975   14.60861  1.000 17.19035 ? 172 HIS A CD2 1 
ATOM   1327 C CE1 . HIS A 1 171 ? 6.80793  3.96356   13.27653  1.000 23.17507 ? 172 HIS A CE1 1 
ATOM   1328 N NE2 . HIS A 1 171 ? 6.91945  3.42511   14.47828  1.000 20.57886 ? 172 HIS A NE2 1 
ATOM   1329 N N   . ALA A 1 172 ? 13.14748 2.19564   14.06484  1.000 20.18784 ? 173 ALA A N   1 
ATOM   1330 C CA  . ALA A 1 172 ? 14.50997 1.70321   13.93199  1.000 17.95317 ? 173 ALA A CA  1 
ATOM   1331 C C   . ALA A 1 172 ? 14.48420 0.18935   13.95664  1.000 14.37124 ? 173 ALA A C   1 
ATOM   1332 O O   . ALA A 1 172 ? 13.66833 -0.42338  14.65466  1.000 15.28339 ? 173 ALA A O   1 
ATOM   1333 C CB  . ALA A 1 172 ? 15.41622 2.21522   15.06259  1.000 17.00344 ? 173 ALA A CB  1 
ATOM   1334 N N   . GLY A 1 173 ? 15.38420 -0.41113  13.19679  1.000 13.76220 ? 174 GLY A N   1 
ATOM   1335 C CA  . GLY A 1 173 ? 15.37263 -1.84687  13.08547  1.000 15.07326 ? 174 GLY A CA  1 
ATOM   1336 C C   . GLY A 1 173 ? 16.68684 -2.29363  12.50288  1.000 15.29789 ? 174 GLY A C   1 
ATOM   1337 O O   . GLY A 1 173 ? 17.61780 -1.49596  12.34005  1.000 15.11945 ? 174 GLY A O   1 
ATOM   1338 N N   . THR A 1 174 ? 16.75180 -3.58212  12.20433  1.000 13.46559 ? 175 THR A N   1 
ATOM   1339 C CA  . THR A 1 174 ? 17.99016 -4.21876  11.79726  1.000 14.16325 ? 175 THR A CA  1 
ATOM   1340 C C   . THR A 1 174 ? 17.83970 -4.86289  10.42803  1.000 13.81204 ? 175 THR A C   1 
ATOM   1341 O O   . THR A 1 174 ? 16.74187 -5.08823  9.92813   1.000 15.49673 ? 175 THR A O   1 
ATOM   1342 C CB  . THR A 1 174 ? 18.40840 -5.30961  12.80531  1.000 14.52923 ? 175 THR A CB  1 
ATOM   1343 O OG1 . THR A 1 174 ? 17.42340 -6.35777  12.79544  1.000 17.74065 ? 175 THR A OG1 1 
ATOM   1344 C CG2 . THR A 1 174 ? 18.53906 -4.74749  14.20162  1.000 15.04664 ? 175 THR A CG2 1 
ATOM   1345 N N   . ASP A 1 175 ? 18.97783 -5.23549  9.84952   1.000 14.77101 ? 176 ASP A N   1 
ATOM   1346 C CA  . ASP A 1 175 ? 18.93873 -6.24407  8.81490   1.000 16.23797 ? 176 ASP A CA  1 
ATOM   1347 C C   . ASP A 1 175 ? 18.64613 -7.61539  9.45447   1.000 17.37994 ? 176 ASP A C   1 
ATOM   1348 O O   . ASP A 1 175 ? 18.50897 -7.74772  10.67881  1.000 19.98311 ? 176 ASP A O   1 
ATOM   1349 C CB  . ASP A 1 175 ? 20.24033 -6.19916  8.00915   1.000 18.98674 ? 176 ASP A CB  1 
ATOM   1350 C CG  . ASP A 1 175 ? 21.47643 -6.55221  8.83485   1.000 19.37848 ? 176 ASP A CG  1 
ATOM   1351 O OD1 . ASP A 1 175 ? 21.36742 -7.30046  9.83741   1.000 18.83603 ? 176 ASP A OD1 1 
ATOM   1352 O OD2 . ASP A 1 175 ? 22.57683 -6.10437  8.43692   1.000 22.72767 ? 176 ASP A OD2 1 
ATOM   1353 N N   . LEU A 1 176 ? 18.56489 -8.65979  8.63472   1.000 18.37686 ? 177 LEU A N   1 
ATOM   1354 C CA  . LEU A 1 176 ? 18.16972 -9.96307  9.15718   1.000 17.90417 ? 177 LEU A CA  1 
ATOM   1355 C C   . LEU A 1 176 ? 19.34220 -10.73436 9.74490   1.000 20.69132 ? 177 LEU A C   1 
ATOM   1356 O O   . LEU A 1 176 ? 19.16804 -11.88083 10.17123  1.000 22.20989 ? 177 LEU A O   1 
ATOM   1357 C CB  . LEU A 1 176 ? 17.47764 -10.80260 8.07415   1.000 16.33287 ? 177 LEU A CB  1 
ATOM   1358 C CG  . LEU A 1 176 ? 15.95605 -10.63534 8.02042   1.000 16.32040 ? 177 LEU A CG  1 
ATOM   1359 C CD1 . LEU A 1 176 ? 15.27794 -11.15916 9.27992   1.000 17.84198 ? 177 LEU A CD1 1 
ATOM   1360 C CD2 . LEU A 1 176 ? 15.55727 -9.16317  7.74393   1.000 18.03373 ? 177 LEU A CD2 1 
ATOM   1361 N N   . GLU A 1 177 ? 20.52730 -10.14469 9.73954   1.000 20.22010 ? 178 GLU A N   1 
ATOM   1362 C CA  . GLU A 1 177 ? 21.63134 -10.61281 10.55333  1.000 23.18133 ? 178 GLU A CA  1 
ATOM   1363 C C   . GLU A 1 177 ? 21.73300 -9.83792  11.85868  1.000 20.34558 ? 178 GLU A C   1 
ATOM   1364 O O   . GLU A 1 177 ? 22.68315 -10.03914 12.61899  1.000 21.17925 ? 178 GLU A O   1 
ATOM   1365 C CB  . GLU A 1 177 ? 22.92297 -10.53935 9.74717   1.000 23.18775 ? 178 GLU A CB  1 
ATOM   1366 C CG  . GLU A 1 177 ? 22.87312 -11.48213 8.55022   1.000 25.96305 ? 178 GLU A CG  1 
ATOM   1367 C CD  . GLU A 1 177 ? 24.19519 -11.59593 7.83585   1.000 40.29130 ? 178 GLU A CD  1 
ATOM   1368 O OE1 . GLU A 1 177 ? 24.95251 -12.53244 8.15066   1.000 42.95064 ? 178 GLU A OE1 1 
ATOM   1369 O OE2 . GLU A 1 177 ? 24.47900 -10.75599 6.95875   1.000 42.08425 ? 178 GLU A OE2 1 
ATOM   1370 N N   . GLY A 1 178 ? 20.75237 -8.98153  12.15321  1.000 17.75867 ? 179 GLY A N   1 
ATOM   1371 C CA  . GLY A 1 178 ? 20.68609 -8.34691  13.45063  1.000 20.96462 ? 179 GLY A CA  1 
ATOM   1372 C C   . GLY A 1 178 ? 21.49180 -7.07923  13.63504  1.000 17.94817 ? 179 GLY A C   1 
ATOM   1373 O O   . GLY A 1 178 ? 21.57444 -6.58672  14.75949  1.000 18.97182 ? 179 GLY A O   1 
ATOM   1374 N N   . ASN A 1 179 ? 22.08361 -6.52705  12.58095  1.000 18.22959 ? 180 ASN A N   1 
ATOM   1375 C CA  . ASN A 1 179 ? 22.81802 -5.27598  12.69165  1.000 16.95172 ? 180 ASN A CA  1 
ATOM   1376 C C   . ASN A 1 179 ? 21.85389 -4.11761  12.50295  1.000 16.90098 ? 180 ASN A C   1 
ATOM   1377 O O   . ASN A 1 179 ? 21.20140 -4.02046  11.45736  1.000 16.11982 ? 180 ASN A O   1 
ATOM   1378 C CB  . ASN A 1 179 ? 23.92258 -5.19354  11.64302  1.000 20.60935 ? 180 ASN A CB  1 
ATOM   1379 C CG  . ASN A 1 179 ? 24.75722 -6.44281  11.60432  1.000 22.54634 ? 180 ASN A CG  1 
ATOM   1380 O OD1 . ASN A 1 179 ? 24.61278 -7.28533  10.71583  1.000 26.95209 ? 180 ASN A OD1 1 
ATOM   1381 N ND2 . ASN A 1 179 ? 25.61914 -6.58160  12.58872  1.000 22.11795 ? 180 ASN A ND2 1 
ATOM   1382 N N   . PHE A 1 180 ? 21.79059 -3.22392  13.48465  1.000 17.17272 ? 181 PHE A N   1 
ATOM   1383 C CA  . PHE A 1 180 ? 20.91651 -2.06484  13.32902  1.000 15.89646 ? 181 PHE A CA  1 
ATOM   1384 C C   . PHE A 1 180 ? 21.29553 -1.23183  12.11506  1.000 16.63280 ? 181 PHE A C   1 
ATOM   1385 O O   . PHE A 1 180 ? 22.46944 -1.06324  11.78725  1.000 16.47577 ? 181 PHE A O   1 
ATOM   1386 C CB  . PHE A 1 180 ? 20.94977 -1.18602  14.57872  1.000 17.47368 ? 181 PHE A CB  1 
ATOM   1387 C CG  . PHE A 1 180 ? 19.82520 -1.47199  15.50773  1.000 15.80279 ? 181 PHE A CG  1 
ATOM   1388 C CD1 . PHE A 1 180 ? 18.58981 -0.87328  15.33152  1.000 16.32340 ? 181 PHE A CD1 1 
ATOM   1389 C CD2 . PHE A 1 180 ? 19.98980 -2.39742  16.52838  1.000 18.13003 ? 181 PHE A CD2 1 
ATOM   1390 C CE1 . PHE A 1 180 ? 17.54239 -1.17182  16.18572  1.000 17.11289 ? 181 PHE A CE1 1 
ATOM   1391 C CE2 . PHE A 1 180 ? 18.94359 -2.69905  17.39253  1.000 18.23965 ? 181 PHE A CE2 1 
ATOM   1392 C CZ  . PHE A 1 180 ? 17.72915 -2.09531  17.21933  1.000 17.20349 ? 181 PHE A CZ  1 
ATOM   1393 N N   . TYR A 1 181 ? 20.28247 -0.70840  11.43613  1.000 16.13533 ? 182 TYR A N   1 
ATOM   1394 C CA  . TYR A 1 181 ? 20.52417 0.41871   10.55667  1.000 14.94506 ? 182 TYR A CA  1 
ATOM   1395 C C   . TYR A 1 181 ? 20.69031 1.65803   11.41928  1.000 15.05147 ? 182 TYR A C   1 
ATOM   1396 O O   . TYR A 1 181 ? 19.84254 1.94688   12.26764  1.000 18.49094 ? 182 TYR A O   1 
ATOM   1397 C CB  . TYR A 1 181 ? 19.37771 0.60192   9.57974   1.000 16.80052 ? 182 TYR A CB  1 
ATOM   1398 C CG  . TYR A 1 181 ? 19.24925 -0.47987  8.54331   1.000 16.15080 ? 182 TYR A CG  1 
ATOM   1399 C CD1 . TYR A 1 181 ? 20.04124 -0.46901  7.39428   1.000 17.78327 ? 182 TYR A CD1 1 
ATOM   1400 C CD2 . TYR A 1 181 ? 18.33861 -1.49127  8.69749   1.000 15.87232 ? 182 TYR A CD2 1 
ATOM   1401 C CE1 . TYR A 1 181 ? 19.92817 -1.43836  6.44862   1.000 15.73862 ? 182 TYR A CE1 1 
ATOM   1402 C CE2 . TYR A 1 181 ? 18.20841 -2.47255  7.74545   1.000 15.64164 ? 182 TYR A CE2 1 
ATOM   1403 C CZ  . TYR A 1 181 ? 19.01116 -2.44003  6.61731   1.000 16.53266 ? 182 TYR A CZ  1 
ATOM   1404 O OH  . TYR A 1 181 ? 18.87733 -3.41168  5.65066   1.000 17.59947 ? 182 TYR A OH  1 
ATOM   1405 N N   . GLY A 1 182 ? 21.77667 2.38848   11.21480  1.000 18.13241 ? 183 GLY A N   1 
ATOM   1406 C CA  . GLY A 1 182 ? 21.98787 3.61955   11.94565  1.000 16.62689 ? 183 GLY A CA  1 
ATOM   1407 C C   . GLY A 1 182 ? 22.57543 3.41179   13.32700  1.000 17.55340 ? 183 GLY A C   1 
ATOM   1408 O O   . GLY A 1 182 ? 22.98346 2.30937   13.70405  1.000 20.04496 ? 183 GLY A O   1 
ATOM   1409 N N   . PRO A 1 183 ? 22.61201 4.47523   14.12345  1.000 19.32492 ? 184 PRO A N   1 
ATOM   1410 C CA  . PRO A 1 183 ? 23.31586 4.43225   15.41958  1.000 19.89359 ? 184 PRO A CA  1 
ATOM   1411 C C   . PRO A 1 183 ? 22.52502 3.84065   16.57906  1.000 23.25556 ? 184 PRO A C   1 
ATOM   1412 O O   . PRO A 1 183 ? 22.94147 3.98957   17.73594  1.000 23.07344 ? 184 PRO A O   1 
ATOM   1413 C CB  . PRO A 1 183 ? 23.60164 5.91999   15.67718  1.000 19.79699 ? 184 PRO A CB  1 
ATOM   1414 C CG  . PRO A 1 183 ? 22.46431 6.63605   15.02326  1.000 23.78275 ? 184 PRO A CG  1 
ATOM   1415 C CD  . PRO A 1 183 ? 22.03697 5.79984   13.83699  1.000 21.66377 ? 184 PRO A CD  1 
ATOM   1416 N N   . PHE A 1 184 ? 21.41837 3.16968   16.32891  1.000 18.50867 ? 185 PHE A N   1 
ATOM   1417 C CA  . PHE A 1 184 ? 20.48614 2.89161   17.40612  1.000 17.21630 ? 185 PHE A CA  1 
ATOM   1418 C C   . PHE A 1 184 ? 20.84166 1.60335   18.13327  1.000 19.07763 ? 185 PHE A C   1 
ATOM   1419 O O   . PHE A 1 184 ? 21.53844 0.73323   17.60949  1.000 20.57097 ? 185 PHE A O   1 
ATOM   1420 C CB  . PHE A 1 184 ? 19.07498 2.85248   16.84629  1.000 18.19362 ? 185 PHE A CB  1 
ATOM   1421 C CG  . PHE A 1 184 ? 18.79262 4.01912   15.96524  1.000 17.28989 ? 185 PHE A CG  1 
ATOM   1422 C CD1 . PHE A 1 184 ? 18.74245 5.29764   16.50649  1.000 20.22003 ? 185 PHE A CD1 1 
ATOM   1423 C CD2 . PHE A 1 184 ? 18.63988 3.86139   14.60381  1.000 19.34187 ? 185 PHE A CD2 1 
ATOM   1424 C CE1 . PHE A 1 184 ? 18.51208 6.40740   15.69904  1.000 21.36112 ? 185 PHE A CE1 1 
ATOM   1425 C CE2 . PHE A 1 184 ? 18.41515 4.95699   13.80483  1.000 20.21541 ? 185 PHE A CE2 1 
ATOM   1426 C CZ  . PHE A 1 184 ? 18.35591 6.23112   14.35316  1.000 20.44369 ? 185 PHE A CZ  1 
ATOM   1427 N N   . VAL A 1 185 ? 20.38818 1.52361   19.38116  1.000 19.75726 ? 186 VAL A N   1 
ATOM   1428 C CA  . VAL A 1 185 ? 20.62524 0.38233   20.25168  1.000 17.41262 ? 186 VAL A CA  1 
ATOM   1429 C C   . VAL A 1 185 ? 19.29070 -0.06881  20.81952  1.000 19.43501 ? 186 VAL A C   1 
ATOM   1430 O O   . VAL A 1 185 ? 18.35979 0.72864   20.96335  1.000 19.80020 ? 186 VAL A O   1 
ATOM   1431 C CB  . VAL A 1 185 ? 21.60054 0.72843   21.39541  1.000 22.55583 ? 186 VAL A CB  1 
ATOM   1432 C CG1 . VAL A 1 185 ? 22.99312 0.96311   20.84998  1.000 25.88860 ? 186 VAL A CG1 1 
ATOM   1433 C CG2 . VAL A 1 185 ? 21.10762 1.94883   22.14693  1.000 23.26824 ? 186 VAL A CG2 1 
ATOM   1434 N N   . ASP A 1 186 ? 19.19759 -1.35510  21.16353  1.000 17.85398 ? 187 ASP A N   1 
ATOM   1435 C CA  . ASP A 1 186 ? 17.93114 -1.90962  21.62931  1.000 16.19056 ? 187 ASP A CA  1 
ATOM   1436 C C   . ASP A 1 186 ? 17.86861 -1.88858  23.15676  1.000 19.01661 ? 187 ASP A C   1 
ATOM   1437 O O   . ASP A 1 186 ? 17.89067 -2.91360  23.84435  1.000 20.32034 ? 187 ASP A O   1 
ATOM   1438 C CB  . ASP A 1 186 ? 17.70188 -3.31673  21.06272  1.000 15.62623 ? 187 ASP A CB  1 
ATOM   1439 C CG  . ASP A 1 186 ? 18.89151 -4.26587  21.24512  1.000 18.96489 ? 187 ASP A CG  1 
ATOM   1440 O OD1 . ASP A 1 186 ? 20.00810 -3.85212  21.65042  1.000 21.06765 ? 187 ASP A OD1 1 
ATOM   1441 O OD2 . ASP A 1 186 ? 18.68506 -5.46932  20.97836  1.000 17.78306 ? 187 ASP A OD2 1 
ATOM   1442 N N   . ARG A 1 187 ? 17.76594 -0.67000  23.67609  1.000 18.65501 ? 188 ARG A N   1 
ATOM   1443 C CA  . ARG A 1 187 ? 17.52375 -0.44625  25.08786  1.000 22.26554 ? 188 ARG A CA  1 
ATOM   1444 C C   . ARG A 1 187 ? 16.72340 0.83972   25.21840  1.000 22.65459 ? 188 ARG A C   1 
ATOM   1445 O O   . ARG A 1 187 ? 16.66903 1.65376   24.29505  1.000 24.53832 ? 188 ARG A O   1 
ATOM   1446 C CB  . ARG A 1 187 ? 18.83579 -0.37040  25.87501  1.000 23.49878 ? 188 ARG A CB  1 
ATOM   1447 C CG  . ARG A 1 187 ? 19.80120 0.66319   25.32433  1.000 28.75532 ? 188 ARG A CG  1 
ATOM   1448 C CD  . ARG A 1 187 ? 21.15083 0.60518   26.03503  1.000 32.30764 ? 188 ARG A CD  1 
ATOM   1449 N NE  . ARG A 1 187 ? 21.15453 1.41128   27.25677  1.000 40.25334 ? 188 ARG A NE  1 
ATOM   1450 C CZ  . ARG A 1 187 ? 21.71740 2.61056   27.37059  1.000 39.23689 ? 188 ARG A CZ  1 
ATOM   1451 N NH1 . ARG A 1 187 ? 22.33853 3.16669   26.33452  1.000 44.11376 ? 188 ARG A NH1 1 
ATOM   1452 N NH2 . ARG A 1 187 ? 21.66299 3.25120   28.53102  1.000 42.70270 ? 188 ARG A NH2 1 
ATOM   1453 N N   . GLN A 1 188 ? 16.08241 1.00383   26.36964  1.000 22.79185 ? 189 GLN A N   1 
ATOM   1454 C CA  . GLN A 1 188 ? 15.20492 2.14852   26.60901  1.000 25.45925 ? 189 GLN A CA  1 
ATOM   1455 C C   . GLN A 1 188 ? 16.06872 3.30499   27.07425  1.000 28.04288 ? 189 GLN A C   1 
ATOM   1456 O O   . GLN A 1 188 ? 16.29533 3.50357   28.27140  1.000 32.02545 ? 189 GLN A O   1 
ATOM   1457 C CB  . GLN A 1 188 ? 14.12869 1.79472   27.62532  1.000 25.42404 ? 189 GLN A CB  1 
ATOM   1458 C CG  . GLN A 1 188 ? 13.09558 2.87906   27.82274  1.000 28.76334 ? 189 GLN A CG  1 
ATOM   1459 C CD  . GLN A 1 188 ? 11.86997 2.37102   28.55741  1.000 29.30891 ? 189 GLN A CD  1 
ATOM   1460 O OE1 . GLN A 1 188 ? 11.37937 1.27316   28.28599  1.000 35.62213 ? 189 GLN A OE1 1 
ATOM   1461 N NE2 . GLN A 1 188 ? 11.38321 3.15478   29.50828  1.000 29.26821 ? 189 GLN A NE2 1 
ATOM   1462 N N   . THR A 1 189 ? 16.58286 4.06444   26.11304  1.000 30.43033 ? 190 THR A N   1 
ATOM   1463 C CA  . THR A 1 189 ? 17.46457 5.17462   26.42292  1.000 33.09310 ? 190 THR A CA  1 
ATOM   1464 C C   . THR A 1 189 ? 17.17148 6.29039   25.43799  1.000 34.92289 ? 190 THR A C   1 
ATOM   1465 O O   . THR A 1 189 ? 16.56719 6.07078   24.38523  1.000 29.17387 ? 190 THR A O   1 
ATOM   1466 C CB  . THR A 1 189 ? 18.94149 4.74709   26.38074  1.000 32.91659 ? 190 THR A CB  1 
ATOM   1467 O OG1 . THR A 1 189 ? 19.72683 5.61752   27.20845  1.000 38.15142 ? 190 THR A OG1 1 
ATOM   1468 C CG2 . THR A 1 189 ? 19.47004 4.78158   24.96096  1.000 34.37336 ? 190 THR A CG2 1 
ATOM   1469 N N   . ALA A 1 190 ? 17.57175 7.50228   25.80692  1.000 38.88450 ? 191 ALA A N   1 
ATOM   1470 C CA  . ALA A 1 190 ? 17.42424 8.63097   24.89882  1.000 37.91055 ? 191 ALA A CA  1 
ATOM   1471 C C   . ALA A 1 190 ? 18.29460 8.40374   23.67490  1.000 34.85543 ? 191 ALA A C   1 
ATOM   1472 O O   . ALA A 1 190 ? 19.49584 8.13470   23.79648  1.000 36.65328 ? 191 ALA A O   1 
ATOM   1473 C CB  . ALA A 1 190 ? 17.80703 9.93767   25.59646  1.000 39.64207 ? 191 ALA A CB  1 
ATOM   1474 N N   . GLN A 1 191 ? 17.68560 8.47936   22.49371  1.000 32.20189 ? 192 GLN A N   1 
ATOM   1475 C CA  . GLN A 1 191 ? 18.39291 8.19489   21.25342  1.000 30.71149 ? 192 GLN A CA  1 
ATOM   1476 C C   . GLN A 1 191 ? 18.03603 9.23702   20.21224  1.000 34.71516 ? 192 GLN A C   1 
ATOM   1477 O O   . GLN A 1 191 ? 16.86750 9.38731   19.84719  1.000 38.74932 ? 192 GLN A O   1 
ATOM   1478 C CB  . GLN A 1 191 ? 18.06089 6.79585   20.74047  1.000 33.01831 ? 192 GLN A CB  1 
ATOM   1479 C CG  . GLN A 1 191 ? 18.54000 5.71503   21.65908  1.000 32.45237 ? 192 GLN A CG  1 
ATOM   1480 C CD  . GLN A 1 191 ? 18.47324 4.35883   21.01841  1.000 27.02417 ? 192 GLN A CD  1 
ATOM   1481 O OE1 . GLN A 1 191 ? 19.09407 4.13330   19.98880  1.000 24.28419 ? 192 GLN A OE1 1 
ATOM   1482 N NE2 . GLN A 1 191 ? 17.73026 3.44121   21.62821  1.000 27.79168 ? 192 GLN A NE2 1 
ATOM   1483 N N   . ALA A 1 192 ? 19.04681 9.94317   19.73074  1.000 36.69535 ? 193 ALA A N   1 
ATOM   1484 C CA  . ALA A 1 192 ? 18.86020 10.93313  18.68876  1.000 35.64935 ? 193 ALA A CA  1 
ATOM   1485 C C   . ALA A 1 192 ? 19.04439 10.26787  17.33451  1.000 29.62579 ? 193 ALA A C   1 
ATOM   1486 O O   . ALA A 1 192 ? 19.99805 9.51130   17.13184  1.000 30.72737 ? 193 ALA A O   1 
ATOM   1487 C CB  . ALA A 1 192 ? 19.85240 12.08474  18.85587  1.000 35.41131 ? 193 ALA A CB  1 
ATOM   1488 N N   . ALA A 1 193 ? 18.11907 10.52402  16.42282  1.000 32.53720 ? 194 ALA A N   1 
ATOM   1489 C CA  . ALA A 1 193 ? 18.39416 10.29284  15.01586  1.000 31.45654 ? 194 ALA A CA  1 
ATOM   1490 C C   . ALA A 1 193 ? 19.07296 11.53729  14.46023  1.000 33.70316 ? 194 ALA A C   1 
ATOM   1491 O O   . ALA A 1 193 ? 18.80731 12.65522  14.90412  1.000 34.73678 ? 194 ALA A O   1 
ATOM   1492 C CB  . ALA A 1 193 ? 17.11265 9.99110   14.24136  1.000 29.09220 ? 194 ALA A CB  1 
ATOM   1493 N N   . GLY A 1 194 ? 19.97247 11.34427  13.51056  1.000 30.67626 ? 195 GLY A N   1 
ATOM   1494 C CA  . GLY A 1 194 ? 20.63339 12.48574  12.90577  1.000 31.68552 ? 195 GLY A CA  1 
ATOM   1495 C C   . GLY A 1 194 ? 19.64665 13.36273  12.14867  1.000 34.63838 ? 195 GLY A C   1 
ATOM   1496 O O   . GLY A 1 194 ? 18.46066 13.04839  12.00308  1.000 29.00331 ? 195 GLY A O   1 
ATOM   1497 N N   . THR A 1 195 ? 20.14908 14.50458  11.67178  1.000 30.31011 ? 196 THR A N   1 
ATOM   1498 C CA  . THR A 1 195 ? 19.35861 15.31306  10.74690  1.000 25.98216 ? 196 THR A CA  1 
ATOM   1499 C C   . THR A 1 195 ? 18.94111 14.47573  9.54911   1.000 26.85439 ? 196 THR A C   1 
ATOM   1500 O O   . THR A 1 195 ? 19.76235 13.78094  8.94591   1.000 26.07028 ? 196 THR A O   1 
ATOM   1501 C CB  . THR A 1 195 ? 20.13906 16.52263  10.24058  1.000 28.19180 ? 196 THR A CB  1 
ATOM   1502 O OG1 . THR A 1 195 ? 20.72564 17.22992  11.33217  1.000 28.26767 ? 196 THR A OG1 1 
ATOM   1503 C CG2 . THR A 1 195 ? 19.19280 17.45534  9.47709   1.000 30.55430 ? 196 THR A CG2 1 
ATOM   1504 N N   . ASP A 1 196 ? 17.66636 14.55265  9.19613   1.000 23.81746 ? 197 ASP A N   1 
ATOM   1505 C CA  . ASP A 1 196 ? 17.17886 13.85120  8.01917   1.000 25.46585 ? 197 ASP A CA  1 
ATOM   1506 C C   . ASP A 1 196 ? 17.27608 14.78243  6.82124   1.000 28.01014 ? 197 ASP A C   1 
ATOM   1507 O O   . ASP A 1 196 ? 17.08610 15.99521  6.94394   1.000 34.76839 ? 197 ASP A O   1 
ATOM   1508 C CB  . ASP A 1 196 ? 15.74121 13.38438  8.21611   1.000 24.68194 ? 197 ASP A CB  1 
ATOM   1509 C CG  . ASP A 1 196 ? 15.35988 12.25290  7.26597   1.000 28.58134 ? 197 ASP A CG  1 
ATOM   1510 O OD1 . ASP A 1 196 ? 16.25031 11.70821  6.57002   1.000 28.75455 ? 197 ASP A OD1 1 
ATOM   1511 O OD2 . ASP A 1 196 ? 14.17227 11.90012  7.23727   1.000 26.46476 ? 197 ASP A OD2 1 
ATOM   1512 N N   . THR A 1 197 ? 17.59852 14.21072  5.67558   1.000 26.90073 ? 198 THR A N   1 
ATOM   1513 C CA  . THR A 1 197 ? 17.76608 14.94715  4.43977   1.000 26.67964 ? 198 THR A CA  1 
ATOM   1514 C C   . THR A 1 197 ? 16.81277 14.37316  3.39923   1.000 23.85320 ? 198 THR A C   1 
ATOM   1515 O O   . THR A 1 197 ? 16.32974 13.24666  3.53430   1.000 22.57113 ? 198 THR A O   1 
ATOM   1516 C CB  . THR A 1 197 ? 19.21104 14.84438  3.95682   1.000 29.84620 ? 198 THR A CB  1 
ATOM   1517 O OG1 . THR A 1 197 ? 19.52702 13.46298  3.76623   1.000 26.41591 ? 198 THR A OG1 1 
ATOM   1518 C CG2 . THR A 1 197 ? 20.15977 15.39781  5.01032   1.000 31.33592 ? 198 THR A CG2 1 
ATOM   1519 N N   . THR A 1 198 ? 16.55260 15.15216  2.35514   1.000 22.28172 ? 199 THR A N   1 
ATOM   1520 C CA  . THR A 1 198 ? 15.65322 14.71432  1.30306   1.000 22.60370 ? 199 THR A CA  1 
ATOM   1521 C C   . THR A 1 198 ? 16.43639 13.90112  0.28415   1.000 22.92471 ? 199 THR A C   1 
ATOM   1522 O O   . THR A 1 198 ? 17.57002 14.24062  -0.06771  1.000 24.23680 ? 199 THR A O   1 
ATOM   1523 C CB  . THR A 1 198 ? 14.95608 15.89487  0.61812   1.000 23.68781 ? 199 THR A CB  1 
ATOM   1524 O OG1 . THR A 1 198 ? 14.23904 16.65531  1.58894   1.000 23.79545 ? 199 THR A OG1 1 
ATOM   1525 C CG2 . THR A 1 198 ? 13.93501 15.37615  -0.37784  1.000 18.67023 ? 199 THR A CG2 1 
ATOM   1526 N N   . ILE A 1 199 ? 15.83804 12.79686  -0.15061  1.000 19.46091 ? 200 ILE A N   1 
ATOM   1527 C CA  . ILE A 1 199 ? 16.45985 11.89341  -1.10713  1.000 19.04851 ? 200 ILE A CA  1 
ATOM   1528 C C   . ILE A 1 199 ? 16.27850 12.43839  -2.51643  1.000 18.93782 ? 200 ILE A C   1 
ATOM   1529 O O   . ILE A 1 199 ? 15.28819 12.13713  -3.19044  1.000 20.23885 ? 200 ILE A O   1 
ATOM   1530 C CB  . ILE A 1 199 ? 15.86233 10.48244  -0.98785  1.000 18.91156 ? 200 ILE A CB  1 
ATOM   1531 C CG1 . ILE A 1 199 ? 15.89858 10.02091  0.47653   1.000 18.33161 ? 200 ILE A CG1 1 
ATOM   1532 C CG2 . ILE A 1 199 ? 16.58245 9.53492   -1.94210  1.000 21.99014 ? 200 ILE A CG2 1 
ATOM   1533 C CD1 . ILE A 1 199 ? 14.89027 8.91548   0.79145   1.000 20.00242 ? 200 ILE A CD1 1 
ATOM   1534 N N   . THR A 1 200 ? 17.28005 13.18300  -2.98800  1.000 20.65885 ? 201 THR A N   1 
ATOM   1535 C CA  . THR A 1 200 ? 17.17174 13.93561  -4.22950  1.000 20.21758 ? 201 THR A CA  1 
ATOM   1536 C C   . THR A 1 200 ? 16.87801 13.05284  -5.43104  1.000 17.97109 ? 201 THR A C   1 
ATOM   1537 O O   . THR A 1 200 ? 16.05833 13.41994  -6.27457  1.000 18.30289 ? 201 THR A O   1 
ATOM   1538 C CB  . THR A 1 200 ? 18.46311 14.72262  -4.44968  1.000 23.58535 ? 201 THR A CB  1 
ATOM   1539 O OG1 . THR A 1 200 ? 18.74648 15.43979  -3.25381  1.000 26.11349 ? 201 THR A OG1 1 
ATOM   1540 C CG2 . THR A 1 200 ? 18.31779 15.70726  -5.59798  1.000 23.54493 ? 201 THR A CG2 1 
ATOM   1541 N N   . VAL A 1 201 ? 17.56697 11.91180  -5.55781  1.000 17.22588 ? 202 VAL A N   1 
ATOM   1542 C CA  . VAL A 1 201 ? 17.36233 11.06926  -6.73339  1.000 20.95758 ? 202 VAL A CA  1 
ATOM   1543 C C   . VAL A 1 201 ? 15.92594 10.55700  -6.76383  1.000 16.33848 ? 202 VAL A C   1 
ATOM   1544 O O   . VAL A 1 201 ? 15.34896 10.35694  -7.84309  1.000 15.05380 ? 202 VAL A O   1 
ATOM   1545 C CB  . VAL A 1 201 ? 18.40746 9.92615   -6.76293  1.000 17.96782 ? 202 VAL A CB  1 
ATOM   1546 C CG1 . VAL A 1 201 ? 18.25557 9.01148   -5.55436  1.000 18.20449 ? 202 VAL A CG1 1 
ATOM   1547 C CG2 . VAL A 1 201 ? 18.34148 9.14932   -8.08984  1.000 21.22246 ? 202 VAL A CG2 1 
ATOM   1548 N N   . ASN A 1 202 ? 15.32312 10.36037  -5.58922  1.000 16.47400 ? 203 ASN A N   1 
ATOM   1549 C CA  . ASN A 1 202 ? 13.92666 9.93318   -5.52012  1.000 19.10413 ? 203 ASN A CA  1 
ATOM   1550 C C   . ASN A 1 202 ? 12.96881 11.06229  -5.88616  1.000 15.93255 ? 203 ASN A C   1 
ATOM   1551 O O   . ASN A 1 202 ? 11.94359 10.82331  -6.53499  1.000 16.05754 ? 203 ASN A O   1 
ATOM   1552 C CB  . ASN A 1 202 ? 13.60005 9.42157   -4.11809  1.000 15.56518 ? 203 ASN A CB  1 
ATOM   1553 C CG  . ASN A 1 202 ? 14.22572 8.06882   -3.82421  1.000 20.06512 ? 203 ASN A CG  1 
ATOM   1554 O OD1 . ASN A 1 202 ? 14.94182 7.50514   -4.65703  1.000 19.43674 ? 203 ASN A OD1 1 
ATOM   1555 N ND2 . ASN A 1 202 ? 13.95312 7.54115   -2.63703  1.000 19.63704 ? 203 ASN A ND2 1 
ATOM   1556 N N   . VAL A 1 203 ? 13.25604 12.29728  -5.45885  1.000 16.33644 ? 204 VAL A N   1 
ATOM   1557 C CA  . VAL A 1 203 ? 12.39474 13.40518  -5.87128  1.000 15.20246 ? 204 VAL A CA  1 
ATOM   1558 C C   . VAL A 1 203 ? 12.41357 13.54611  -7.37379  1.000 17.78968 ? 204 VAL A C   1 
ATOM   1559 O O   . VAL A 1 203 ? 11.37239 13.74912  -8.00024  1.000 17.05504 ? 204 VAL A O   1 
ATOM   1560 C CB  . VAL A 1 203 ? 12.81624 14.72199  -5.18894  1.000 15.80999 ? 204 VAL A CB  1 
ATOM   1561 C CG1 . VAL A 1 203 ? 11.99295 15.88290  -5.75100  1.000 18.37416 ? 204 VAL A CG1 1 
ATOM   1562 C CG2 . VAL A 1 203 ? 12.65654 14.62886  -3.69386  1.000 20.83772 ? 204 VAL A CG2 1 
ATOM   1563 N N   . LEU A 1 204 ? 13.59746 13.40288  -7.98309  1.000 18.45191 ? 205 LEU A N   1 
ATOM   1564 C CA  . LEU A 1 204 ? 13.69558 13.43173  -9.44353  1.000 18.97159 ? 205 LEU A CA  1 
ATOM   1565 C C   . LEU A 1 204 ? 12.90367 12.30163  -10.08829 1.000 19.59501 ? 205 LEU A C   1 
ATOM   1566 O O   . LEU A 1 204 ? 12.22598 12.51342  -11.10252 1.000 18.88043 ? 205 LEU A O   1 
ATOM   1567 C CB  . LEU A 1 204 ? 15.16604 13.36147  -9.87003  1.000 18.16731 ? 205 LEU A CB  1 
ATOM   1568 C CG  . LEU A 1 204 ? 15.93918 14.62477  -9.46329  1.000 20.93456 ? 205 LEU A CG  1 
ATOM   1569 C CD1 . LEU A 1 204 ? 17.42606 14.43470  -9.65471  1.000 19.68468 ? 205 LEU A CD1 1 
ATOM   1570 C CD2 . LEU A 1 204 ? 15.46447 15.83836  -10.23092 1.000 21.33891 ? 205 LEU A CD2 1 
ATOM   1571 N N   . ALA A 1 205 ? 12.99273 11.08317  -9.54161  1.000 17.30995 ? 206 ALA A N   1 
ATOM   1572 C CA  . ALA A 1 205 ? 12.19308 9.98805   -10.09549 1.000 19.21242 ? 206 ALA A CA  1 
ATOM   1573 C C   . ALA A 1 205 ? 10.70573 10.32657  -10.07186 1.000 18.88999 ? 206 ALA A C   1 
ATOM   1574 O O   . ALA A 1 205 ? 9.97794  10.04265  -11.03422 1.000 18.98145 ? 206 ALA A O   1 
ATOM   1575 C CB  . ALA A 1 205 ? 12.46510 8.69012   -9.32762  1.000 19.78774 ? 206 ALA A CB  1 
ATOM   1576 N N   . TRP A 1 206 ? 10.25234 10.95369  -8.98854  1.000 17.51761 ? 207 TRP A N   1 
ATOM   1577 C CA  . TRP A 1 206 ? 8.84445  11.30597  -8.81487  1.000 19.00329 ? 207 TRP A CA  1 
ATOM   1578 C C   . TRP A 1 206 ? 8.42395  12.44176  -9.73705  1.000 20.45276 ? 207 TRP A C   1 
ATOM   1579 O O   . TRP A 1 206 ? 7.26703  12.49048  -10.18101 1.000 19.75532 ? 207 TRP A O   1 
ATOM   1580 C CB  . TRP A 1 206 ? 8.61980  11.67033  -7.35296  1.000 22.01812 ? 207 TRP A CB  1 
ATOM   1581 C CG  . TRP A 1 206 ? 7.24146  12.14694  -6.97356  1.000 25.22357 ? 207 TRP A CG  1 
ATOM   1582 C CD1 . TRP A 1 206 ? 6.12566  11.37658  -6.75584  1.000 25.48113 ? 207 TRP A CD1 1 
ATOM   1583 C CD2 . TRP A 1 206 ? 6.85311  13.49405  -6.70434  1.000 24.82163 ? 207 TRP A CD2 1 
ATOM   1584 N NE1 . TRP A 1 206 ? 5.07163  12.17011  -6.38390  1.000 26.52754 ? 207 TRP A NE1 1 
ATOM   1585 C CE2 . TRP A 1 206 ? 5.48766  13.47428  -6.35364  1.000 25.01844 ? 207 TRP A CE2 1 
ATOM   1586 C CE3 . TRP A 1 206 ? 7.52126  14.72115  -6.74522  1.000 25.45407 ? 207 TRP A CE3 1 
ATOM   1587 C CZ2 . TRP A 1 206 ? 4.78432  14.63377  -6.03403  1.000 27.79601 ? 207 TRP A CZ2 1 
ATOM   1588 C CZ3 . TRP A 1 206 ? 6.82132  15.86829  -6.42300  1.000 27.88063 ? 207 TRP A CZ3 1 
ATOM   1589 C CH2 . TRP A 1 206 ? 5.46910  15.81560  -6.07212  1.000 26.37806 ? 207 TRP A CH2 1 
ATOM   1590 N N   . LEU A 1 207 ? 9.34264  13.35082  -10.05552 1.000 17.58101 ? 208 LEU A N   1 
ATOM   1591 C CA  . LEU A 1 207 ? 9.02591  14.35237  -11.07277 1.000 17.44270 ? 208 LEU A CA  1 
ATOM   1592 C C   . LEU A 1 207 ? 8.88067  13.70739  -12.44123 1.000 20.43069 ? 208 LEU A C   1 
ATOM   1593 O O   . LEU A 1 207 ? 8.01541  14.10648  -13.22596 1.000 23.63417 ? 208 LEU A O   1 
ATOM   1594 C CB  . LEU A 1 207 ? 10.09451 15.44071  -11.11094 1.000 18.89977 ? 208 LEU A CB  1 
ATOM   1595 C CG  . LEU A 1 207 ? 10.15689 16.29543  -9.85365  1.000 17.68926 ? 208 LEU A CG  1 
ATOM   1596 C CD1 . LEU A 1 207 ? 11.33545 17.25720  -9.91658  1.000 20.35913 ? 208 LEU A CD1 1 
ATOM   1597 C CD2 . LEU A 1 207 ? 8.85184  17.06210  -9.58718  1.000 19.97456 ? 208 LEU A CD2 1 
ATOM   1598 N N   . TYR A 1 208 ? 9.72916  12.72366  -12.75592 1.000 18.82731 ? 209 TYR A N   1 
ATOM   1599 C CA  . TYR A 1 208 ? 9.54950  11.99247  -14.00456 1.000 19.67270 ? 209 TYR A CA  1 
ATOM   1600 C C   . TYR A 1 208 ? 8.20535  11.27991  -14.02044 1.000 22.45070 ? 209 TYR A C   1 
ATOM   1601 O O   . TYR A 1 208 ? 7.52893  11.23365  -15.05861 1.000 21.70596 ? 209 TYR A O   1 
ATOM   1602 C CB  . TYR A 1 208 ? 10.68823 10.99171  -14.21604 1.000 18.54637 ? 209 TYR A CB  1 
ATOM   1603 C CG  . TYR A 1 208 ? 11.93523 11.59888  -14.82901 1.000 19.66534 ? 209 TYR A CG  1 
ATOM   1604 C CD1 . TYR A 1 208 ? 11.97222 11.97620  -16.17250 1.000 25.01885 ? 209 TYR A CD1 1 
ATOM   1605 C CD2 . TYR A 1 208 ? 13.06034 11.82513  -14.05177 1.000 21.38436 ? 209 TYR A CD2 1 
ATOM   1606 C CE1 . TYR A 1 208 ? 13.11993 12.53537  -16.73008 1.000 24.47301 ? 209 TYR A CE1 1 
ATOM   1607 C CE2 . TYR A 1 208 ? 14.20582 12.38278  -14.59194 1.000 21.88308 ? 209 TYR A CE2 1 
ATOM   1608 C CZ  . TYR A 1 208 ? 14.22746 12.74803  -15.92422 1.000 26.16886 ? 209 TYR A CZ  1 
ATOM   1609 O OH  . TYR A 1 208 ? 15.37033 13.30052  -16.44662 1.000 27.67693 ? 209 TYR A OH  1 
ATOM   1610 N N   . ALA A 1 209 ? 7.80883  10.70025  -12.88333 1.000 19.71593 ? 210 ALA A N   1 
ATOM   1611 C CA  . ALA A 1 209 ? 6.49939  10.05417  -12.80733 1.000 22.14534 ? 210 ALA A CA  1 
ATOM   1612 C C   . ALA A 1 209 ? 5.38530  11.05685  -13.07446 1.000 26.99743 ? 210 ALA A C   1 
ATOM   1613 O O   . ALA A 1 209 ? 4.40798  10.74512  -13.77189 1.000 26.31982 ? 210 ALA A O   1 
ATOM   1614 C CB  . ALA A 1 209 ? 6.32169  9.39241   -11.43998 1.000 21.01000 ? 210 ALA A CB  1 
ATOM   1615 N N   . ALA A 1 210 ? 5.52194  12.27123  -12.52926 1.000 23.95329 ? 211 ALA A N   1 
ATOM   1616 C CA  . ALA A 1 210 ? 4.57131  13.34341  -12.81894 1.000 21.84680 ? 211 ALA A CA  1 
ATOM   1617 C C   . ALA A 1 210 ? 4.49481  13.62407  -14.31410 1.000 26.66858 ? 211 ALA A C   1 
ATOM   1618 O O   . ALA A 1 210 ? 3.40277  13.68685  -14.88632 1.000 28.10325 ? 211 ALA A O   1 
ATOM   1619 C CB  . ALA A 1 210 ? 4.96314  14.60472  -12.04778 1.000 24.23690 ? 211 ALA A CB  1 
ATOM   1620 N N   . VAL A 1 211 ? 5.64779  13.78305  -14.96712 1.000 25.38433 ? 212 VAL A N   1 
ATOM   1621 C CA  . VAL A 1 211 ? 5.66642  14.02628  -16.41061 1.000 26.75389 ? 212 VAL A CA  1 
ATOM   1622 C C   . VAL A 1 211 ? 5.02978  12.86263  -17.16785 1.000 29.28088 ? 212 VAL A C   1 
ATOM   1623 O O   . VAL A 1 211 ? 4.21740  13.06494  -18.07949 1.000 27.42240 ? 212 VAL A O   1 
ATOM   1624 C CB  . VAL A 1 211 ? 7.10678  14.28904  -16.88564 1.000 30.01216 ? 212 VAL A CB  1 
ATOM   1625 C CG1 . VAL A 1 211 ? 7.18977  14.23143  -18.41351 1.000 26.78433 ? 212 VAL A CG1 1 
ATOM   1626 C CG2 . VAL A 1 211 ? 7.60702  15.62627  -16.34359 1.000 22.39391 ? 212 VAL A CG2 1 
ATOM   1627 N N   . ILE A 1 212 ? 5.39809  11.62639  -16.81295 1.000 23.96921 ? 213 ILE A N   1 
ATOM   1628 C CA  . ILE A 1 212 ? 4.79586  10.45184  -17.44887 1.000 27.07236 ? 213 ILE A CA  1 
ATOM   1629 C C   . ILE A 1 212 ? 3.27738  10.52621  -17.36939 1.000 27.66118 ? 213 ILE A C   1 
ATOM   1630 O O   . ILE A 1 212 ? 2.56700  10.16574  -18.31652 1.000 32.41939 ? 213 ILE A O   1 
ATOM   1631 C CB  . ILE A 1 212 ? 5.32759  9.15777   -16.79960 1.000 26.43377 ? 213 ILE A CB  1 
ATOM   1632 C CG1 . ILE A 1 212 ? 6.80211  8.94885   -17.13506 1.000 26.89282 ? 213 ILE A CG1 1 
ATOM   1633 C CG2 . ILE A 1 212 ? 4.50736  7.95170   -17.26346 1.000 31.60203 ? 213 ILE A CG2 1 
ATOM   1634 C CD1 . ILE A 1 212 ? 7.45945  7.86344   -16.29490 1.000 27.15635 ? 213 ILE A CD1 1 
ATOM   1635 N N   . ASN A 1 213 ? 2.75654  11.00869  -16.24433 1.000 26.74563 ? 214 ASN A N   1 
ATOM   1636 C CA  . ASN A 1 213 ? 1.32336  11.11618  -16.02229 1.000 31.86761 ? 214 ASN A CA  1 
ATOM   1637 C C   . ASN A 1 213 ? 0.75500  12.46846  -16.45003 1.000 33.50478 ? 214 ASN A C   1 
ATOM   1638 O O   . ASN A 1 213 ? -0.30605 12.86850  -15.95414 1.000 36.51191 ? 214 ASN A O   1 
ATOM   1639 C CB  . ASN A 1 213 ? 1.00324  10.84159  -14.55300 1.000 30.10325 ? 214 ASN A CB  1 
ATOM   1640 C CG  . ASN A 1 213 ? 1.02375  9.35055   -14.22240 1.000 37.09625 ? 214 ASN A CG  1 
ATOM   1641 O OD1 . ASN A 1 213 ? 0.03842  8.64753   -14.44143 1.000 43.07786 ? 214 ASN A OD1 1 
ATOM   1642 N ND2 . ASN A 1 213 ? 2.15717  8.85965   -13.72044 1.000 32.54204 ? 214 ASN A ND2 1 
ATOM   1643 N N   . GLY A 1 214 ? 1.43580  13.17863  -17.35047 1.000 31.15679 ? 215 GLY A N   1 
ATOM   1644 C CA  . GLY A 1 214 ? 0.91954  14.41143  -17.92309 1.000 31.90204 ? 215 GLY A CA  1 
ATOM   1645 C C   . GLY A 1 214 ? 1.00066  15.64321  -17.04409 1.000 35.39413 ? 215 GLY A C   1 
ATOM   1646 O O   . GLY A 1 214 ? 0.63221  16.73537  -17.50068 1.000 35.63033 ? 215 GLY A O   1 
ATOM   1647 N N   . ASP A 1 215 ? 1.46417  15.51857  -15.80453 1.000 32.06519 ? 216 ASP A N   1 
ATOM   1648 C CA  . ASP A 1 215 ? 1.65439  16.67325  -14.92903 1.000 31.47296 ? 216 ASP A CA  1 
ATOM   1649 C C   . ASP A 1 215 ? 3.00874  17.28682  -15.27212 1.000 29.96860 ? 216 ASP A C   1 
ATOM   1650 O O   . ASP A 1 215 ? 4.05609  16.75737  -14.88848 1.000 30.13380 ? 216 ASP A O   1 
ATOM   1651 C CB  . ASP A 1 215 ? 1.57351  16.24955  -13.46791 1.000 33.56652 ? 216 ASP A CB  1 
ATOM   1652 C CG  . ASP A 1 215 ? 0.92977  17.29806  -12.59067 1.000 36.44400 ? 216 ASP A CG  1 
ATOM   1653 O OD1 . ASP A 1 215 ? 0.56739  18.37625  -13.11554 1.000 37.85581 ? 216 ASP A OD1 1 
ATOM   1654 O OD2 . ASP A 1 215 ? 0.78477  17.04240  -11.37502 1.000 36.90696 ? 216 ASP A OD2 1 
ATOM   1655 N N   . ARG A 1 216 ? 2.99200  18.41128  -15.99692 1.000 28.87093 ? 217 ARG A N   1 
ATOM   1656 C CA  . ARG A 1 216 ? 4.18954  18.91744  -16.64816 1.000 29.91569 ? 217 ARG A CA  1 
ATOM   1657 C C   . ARG A 1 216 ? 4.53176  20.36577  -16.35535 1.000 28.95799 ? 217 ARG A C   1 
ATOM   1658 O O   . ARG A 1 216 ? 5.55064  20.83869  -16.86390 1.000 25.82947 ? 217 ARG A O   1 
ATOM   1659 C CB  . ARG A 1 216 ? 4.06503  18.79332  -18.16656 1.000 32.67448 ? 217 ARG A CB  1 
ATOM   1660 C CG  . ARG A 1 216 ? 4.04715  17.39650  -18.67974 1.000 37.43056 ? 217 ARG A CG  1 
ATOM   1661 C CD  . ARG A 1 216 ? 3.88102  17.43195  -20.17369 1.000 33.96571 ? 217 ARG A CD  1 
ATOM   1662 N NE  . ARG A 1 216 ? 5.02138  18.05799  -20.82664 1.000 35.38534 ? 217 ARG A NE  1 
ATOM   1663 C CZ  . ARG A 1 216 ? 6.02829  17.38300  -21.37039 1.000 31.79394 ? 217 ARG A CZ  1 
ATOM   1664 N NH1 . ARG A 1 216 ? 7.02155  18.03612  -21.95667 1.000 33.18003 ? 217 ARG A NH1 1 
ATOM   1665 N NH2 . ARG A 1 216 ? 6.03727  16.05796  -21.33578 1.000 30.13071 ? 217 ARG A NH2 1 
ATOM   1666 N N   . TRP A 1 217 ? 3.73395  21.06794  -15.54566 1.000 26.96143 ? 218 TRP A N   1 
ATOM   1667 C CA  . TRP A 1 217 ? 3.79336  22.52596  -15.48107 1.000 29.50147 ? 218 TRP A CA  1 
ATOM   1668 C C   . TRP A 1 217 ? 5.13701  23.04825  -14.98402 1.000 30.83113 ? 218 TRP A C   1 
ATOM   1669 O O   . TRP A 1 217 ? 5.56694  24.13436  -15.39495 1.000 28.28966 ? 218 TRP A O   1 
ATOM   1670 C CB  . TRP A 1 217 ? 2.67043  23.04512  -14.58736 1.000 27.93341 ? 218 TRP A CB  1 
ATOM   1671 C CG  . TRP A 1 217 ? 2.71470  22.58670  -13.15068 1.000 33.00603 ? 218 TRP A CG  1 
ATOM   1672 C CD1 . TRP A 1 217 ? 1.99672  21.56671  -12.59321 1.000 31.41327 ? 218 TRP A CD1 1 
ATOM   1673 C CD2 . TRP A 1 217 ? 3.48393  23.16057  -12.08520 1.000 31.28319 ? 218 TRP A CD2 1 
ATOM   1674 N NE1 . TRP A 1 217 ? 2.28161  21.46208  -11.25197 1.000 34.11571 ? 218 TRP A NE1 1 
ATOM   1675 C CE2 . TRP A 1 217 ? 3.19285  22.42642  -10.91670 1.000 31.07323 ? 218 TRP A CE2 1 
ATOM   1676 C CE3 . TRP A 1 217 ? 4.40138  24.21383  -12.00866 1.000 29.93225 ? 218 TRP A CE3 1 
ATOM   1677 C CZ2 . TRP A 1 217 ? 3.77769  22.71709  -9.69133  1.000 32.48616 ? 218 TRP A CZ2 1 
ATOM   1678 C CZ3 . TRP A 1 217 ? 4.98610  24.49822  -10.78910 1.000 35.98452 ? 218 TRP A CZ3 1 
ATOM   1679 C CH2 . TRP A 1 217 ? 4.67300  23.75155  -9.64864  1.000 35.36565 ? 218 TRP A CH2 1 
ATOM   1680 N N   . PHE A 1 218 ? 5.80750  22.29416  -14.10674 1.000 27.89330 ? 219 PHE A N   1 
ATOM   1681 C CA  . PHE A 1 218 ? 7.05633  22.69081  -13.46215 1.000 26.07597 ? 219 PHE A CA  1 
ATOM   1682 C C   . PHE A 1 218 ? 8.25547  22.59396  -14.39046 1.000 28.53840 ? 219 PHE A C   1 
ATOM   1683 O O   . PHE A 1 218 ? 9.36611  22.95317  -13.98436 1.000 27.43025 ? 219 PHE A O   1 
ATOM   1684 C CB  . PHE A 1 218 ? 7.29969  21.80001  -12.23161 1.000 26.10707 ? 219 PHE A CB  1 
ATOM   1685 C CG  . PHE A 1 218 ? 7.22210  20.33238  -12.54420 1.000 26.54945 ? 219 PHE A CG  1 
ATOM   1686 C CD1 . PHE A 1 218 ? 6.01414  19.64703  -12.47361 1.000 24.63588 ? 219 PHE A CD1 1 
ATOM   1687 C CD2 . PHE A 1 218 ? 8.35411  19.64515  -12.95623 1.000 24.87589 ? 219 PHE A CD2 1 
ATOM   1688 C CE1 . PHE A 1 218 ? 5.93828  18.29435  -12.79621 1.000 24.19980 ? 219 PHE A CE1 1 
ATOM   1689 C CE2 . PHE A 1 218 ? 8.28915  18.29305  -13.27743 1.000 22.12879 ? 219 PHE A CE2 1 
ATOM   1690 C CZ  . PHE A 1 218 ? 7.07526  17.61692  -13.19664 1.000 23.93881 ? 219 PHE A CZ  1 
ATOM   1691 N N   . LEU A 1 219 ? 8.08007  22.08206  -15.60274 1.000 25.28324 ? 220 LEU A N   1 
ATOM   1692 C CA  . LEU A 1 219 ? 9.21237  21.99722  -16.51189 1.000 27.15370 ? 220 LEU A CA  1 
ATOM   1693 C C   . LEU A 1 219 ? 9.57552  23.40015  -16.97219 1.000 35.31957 ? 220 LEU A C   1 
ATOM   1694 O O   . LEU A 1 219 ? 8.70055  24.24941  -17.16884 1.000 32.17579 ? 220 LEU A O   1 
ATOM   1695 C CB  . LEU A 1 219 ? 8.88786  21.10087  -17.70244 1.000 27.90301 ? 220 LEU A CB  1 
ATOM   1696 C CG  . LEU A 1 219 ? 8.64922  19.61372  -17.40126 1.000 28.52657 ? 220 LEU A CG  1 
ATOM   1697 C CD1 . LEU A 1 219 ? 8.28093  18.87937  -18.67349 1.000 26.75634 ? 220 LEU A CD1 1 
ATOM   1698 C CD2 . LEU A 1 219 ? 9.86730  18.97920  -16.73911 1.000 28.02171 ? 220 LEU A CD2 1 
ATOM   1699 N N   . ASN A 1 220 ? 10.86951 23.65892  -17.10333 1.000 32.60724 ? 221 ASN A N   1 
ATOM   1700 C CA  . ASN A 1 220 ? 11.32452 24.94840  -17.58724 1.000 34.48954 ? 221 ASN A CA  1 
ATOM   1701 C C   . ASN A 1 220 ? 12.30519 24.71959  -18.72634 1.000 36.09663 ? 221 ASN A C   1 
ATOM   1702 O O   . ASN A 1 220 ? 12.65106 23.58468  -19.07327 1.000 32.72830 ? 221 ASN A O   1 
ATOM   1703 C CB  . ASN A 1 220 ? 11.93734 25.80130  -16.46117 1.000 33.95860 ? 221 ASN A CB  1 
ATOM   1704 C CG  . ASN A 1 220 ? 13.18784 25.17971  -15.83381 1.000 31.57690 ? 221 ASN A CG  1 
ATOM   1705 O OD1 . ASN A 1 220 ? 13.93993 24.44570  -16.47187 1.000 33.00537 ? 221 ASN A OD1 1 
ATOM   1706 N ND2 . ASN A 1 220 ? 13.43292 25.52450  -14.57737 1.000 35.10431 ? 221 ASN A ND2 1 
ATOM   1707 N N   . ARG A 1 221 ? 12.75544 25.82245  -19.30599 1.000 36.33756 ? 222 ARG A N   1 
ATOM   1708 C CA  . ARG A 1 221 ? 13.59813 25.77955  -20.48815 1.000 39.82911 ? 222 ARG A CA  1 
ATOM   1709 C C   . ARG A 1 221 ? 15.02391 25.31360  -20.20011 1.000 39.42817 ? 222 ARG A C   1 
ATOM   1710 O O   . ARG A 1 221 ? 15.69533 24.80349  -21.10607 1.000 40.31962 ? 222 ARG A O   1 
ATOM   1711 C CB  . ARG A 1 221 ? 13.58177 27.17902  -21.11927 1.000 39.33670 ? 222 ARG A CB  1 
ATOM   1712 C CG  . ARG A 1 221 ? 14.91123 27.60035  -21.64208 1.000 43.66185 ? 222 ARG A CG  1 
ATOM   1713 C CD  . ARG A 1 221 ? 15.01340 29.07630  -21.89686 1.000 46.66481 ? 222 ARG A CD  1 
ATOM   1714 N NE  . ARG A 1 221 ? 16.40739 29.46663  -21.74935 1.000 47.44644 ? 222 ARG A NE  1 
ATOM   1715 C CZ  . ARG A 1 221 ? 16.92658 30.61665  -22.14946 1.000 44.09685 ? 222 ARG A CZ  1 
ATOM   1716 N NH1 . ARG A 1 221 ? 16.15568 31.52860  -22.73938 1.000 42.76215 ? 222 ARG A NH1 1 
ATOM   1717 N NH2 . ARG A 1 221 ? 18.22632 30.84524  -21.95774 1.000 37.20687 ? 222 ARG A NH2 1 
ATOM   1718 N N   . PHE A 1 222 ? 15.47743 25.43607  -18.96345 1.000 37.77508 ? 223 PHE A N   1 
ATOM   1719 C CA  . PHE A 1 222 ? 16.89920 25.49505  -18.65879 1.000 39.89272 ? 223 PHE A CA  1 
ATOM   1720 C C   . PHE A 1 222 ? 17.51140 24.11622  -18.42129 1.000 37.48466 ? 223 PHE A C   1 
ATOM   1721 O O   . PHE A 1 222 ? 16.82235 23.11051  -18.24376 1.000 32.22509 ? 223 PHE A O   1 
ATOM   1722 C CB  . PHE A 1 222 ? 17.12821 26.37457  -17.43606 1.000 36.32196 ? 223 PHE A CB  1 
ATOM   1723 C CG  . PHE A 1 222 ? 16.32824 27.64346  -17.45048 1.000 38.19368 ? 223 PHE A CG  1 
ATOM   1724 C CD1 . PHE A 1 222 ? 16.59290 28.63423  -18.38060 1.000 36.46415 ? 223 PHE A CD1 1 
ATOM   1725 C CD2 . PHE A 1 222 ? 15.30451 27.84387  -16.53754 1.000 35.81978 ? 223 PHE A CD2 1 
ATOM   1726 C CE1 . PHE A 1 222 ? 15.85655 29.80839  -18.38392 1.000 38.86116 ? 223 PHE A CE1 1 
ATOM   1727 C CE2 . PHE A 1 222 ? 14.56450 29.01102  -16.54705 1.000 35.52093 ? 223 PHE A CE2 1 
ATOM   1728 C CZ  . PHE A 1 222 ? 14.83822 29.99036  -17.46969 1.000 35.03260 ? 223 PHE A CZ  1 
ATOM   1729 N N   . THR A 1 223 ? 18.83457 24.08389  -18.43348 1.000 31.15827 ? 224 THR A N   1 
ATOM   1730 C CA  . THR A 1 223 ? 19.58675 22.95946  -17.91476 1.000 32.41960 ? 224 THR A CA  1 
ATOM   1731 C C   . THR A 1 223 ? 20.50936 23.48551  -16.81693 1.000 35.93838 ? 224 THR A C   1 
ATOM   1732 O O   . THR A 1 223 ? 20.48082 24.66829  -16.46399 1.000 34.36165 ? 224 THR A O   1 
ATOM   1733 C CB  . THR A 1 223 ? 20.35391 22.23954  -19.03343 1.000 34.55405 ? 224 THR A CB  1 
ATOM   1734 O OG1 . THR A 1 223 ? 20.82819 20.97118  -18.55133 1.000 36.55708 ? 224 THR A OG1 1 
ATOM   1735 C CG2 . THR A 1 223 ? 21.53441 23.07692  -19.52145 1.000 37.89946 ? 224 THR A CG2 1 
ATOM   1736 N N   . THR A 1 224 ? 21.30759 22.58958  -16.25035 1.000 31.69754 ? 225 THR A N   1 
ATOM   1737 C CA  . THR A 1 224 ? 22.24312 22.96471  -15.20012 1.000 35.52728 ? 225 THR A CA  1 
ATOM   1738 C C   . THR A 1 224 ? 23.34786 21.92413  -15.19199 1.000 34.23266 ? 225 THR A C   1 
ATOM   1739 O O   . THR A 1 224 ? 23.25384 20.89197  -15.85472 1.000 34.56281 ? 225 THR A O   1 
ATOM   1740 C CB  . THR A 1 224 ? 21.55260 23.06473  -13.82946 1.000 34.75194 ? 225 THR A CB  1 
ATOM   1741 O OG1 . THR A 1 224 ? 22.52499 23.32569  -12.80640 1.000 35.35265 ? 225 THR A OG1 1 
ATOM   1742 C CG2 . THR A 1 224 ? 20.79624 21.76296  -13.50817 1.000 34.41102 ? 225 THR A CG2 1 
ATOM   1743 N N   . THR A 1 225 ? 24.40904 22.21270  -14.45390 1.000 34.71125 ? 226 THR A N   1 
ATOM   1744 C CA  . THR A 1 225 ? 25.43990 21.21751  -14.21340 1.000 35.66255 ? 226 THR A CA  1 
ATOM   1745 C C   . THR A 1 225 ? 25.17216 20.54764  -12.87355 1.000 32.15007 ? 226 THR A C   1 
ATOM   1746 O O   . THR A 1 225 ? 24.51935 21.11867  -11.99449 1.000 32.60466 ? 226 THR A O   1 
ATOM   1747 C CB  . THR A 1 225 ? 26.82993 21.85409  -14.21743 1.000 36.60492 ? 226 THR A CB  1 
ATOM   1748 O OG1 . THR A 1 225 ? 26.94712 22.73272  -13.09158 1.000 37.54110 ? 226 THR A OG1 1 
ATOM   1749 C CG2 . THR A 1 225 ? 27.04586 22.64415  -15.49275 1.000 38.12986 ? 226 THR A CG2 1 
ATOM   1750 N N   . LEU A 1 226 ? 25.66759 19.31282  -12.73642 1.000 34.07653 ? 227 LEU A N   1 
ATOM   1751 C CA  . LEU A 1 226 ? 25.53710 18.60117  -11.47198 1.000 29.25683 ? 227 LEU A CA  1 
ATOM   1752 C C   . LEU A 1 226 ? 26.05015 19.44707  -10.31657 1.000 33.25705 ? 227 LEU A C   1 
ATOM   1753 O O   . LEU A 1 226 ? 25.37819 19.57902  -9.28647  1.000 33.00932 ? 227 LEU A O   1 
ATOM   1754 C CB  . LEU A 1 226 ? 26.28399 17.26835  -11.53669 1.000 35.04640 ? 227 LEU A CB  1 
ATOM   1755 C CG  . LEU A 1 226 ? 25.50004 15.96086  -11.39925 1.000 35.49493 ? 227 LEU A CG  1 
ATOM   1756 C CD1 . LEU A 1 226 ? 26.44423 14.80016  -11.12405 1.000 36.51909 ? 227 LEU A CD1 1 
ATOM   1757 C CD2 . LEU A 1 226 ? 24.43609 16.04500  -10.31478 1.000 31.37558 ? 227 LEU A CD2 1 
ATOM   1758 N N   . ASN A 1 227 ? 27.22679 20.06454  -10.48793 1.000 31.64560 ? 228 ASN A N   1 
ATOM   1759 C CA  . ASN A 1 227 ? 27.79607 20.89746  -9.43193  1.000 32.03320 ? 228 ASN A CA  1 
ATOM   1760 C C   . ASN A 1 227 ? 26.88441 22.07699  -9.11799  1.000 32.57877 ? 228 ASN A C   1 
ATOM   1761 O O   . ASN A 1 227 ? 26.57371 22.34339  -7.95322  1.000 31.33083 ? 228 ASN A O   1 
ATOM   1762 C CB  . ASN A 1 227 ? 29.18651 21.38118  -9.84684  1.000 31.46344 ? 228 ASN A CB  1 
ATOM   1763 C CG  . ASN A 1 227 ? 29.92671 22.07976  -8.71704  1.000 33.24602 ? 228 ASN A CG  1 
ATOM   1764 O OD1 . ASN A 1 227 ? 30.21549 23.27037  -8.79819  1.000 39.56236 ? 228 ASN A OD1 1 
ATOM   1765 N ND2 . ASN A 1 227 ? 30.21724 21.34217  -7.64977  1.000 40.35554 ? 228 ASN A ND2 1 
ATOM   1766 N N   . ASP A 1 228 ? 26.43961 22.79338  -10.15202 1.000 31.41177 ? 229 ASP A N   1 
ATOM   1767 C CA  . ASP A 1 228 ? 25.58169 23.95292  -9.93183  1.000 33.63190 ? 229 ASP A CA  1 
ATOM   1768 C C   . ASP A 1 228 ? 24.28033 23.54633  -9.25150  1.000 35.05641 ? 229 ASP A C   1 
ATOM   1769 O O   . ASP A 1 228 ? 23.79271 24.24520  -8.35588  1.000 32.77322 ? 229 ASP A O   1 
ATOM   1770 C CB  . ASP A 1 228 ? 25.29287 24.66057  -11.25815 1.000 36.20441 ? 229 ASP A CB  1 
ATOM   1771 C CG  . ASP A 1 228 ? 26.34479 25.69150  -11.61117 1.000 42.17641 ? 229 ASP A CG  1 
ATOM   1772 O OD1 . ASP A 1 228 ? 27.17347 26.01266  -10.73067 1.000 41.90611 ? 229 ASP A OD1 1 
ATOM   1773 O OD2 . ASP A 1 228 ? 26.34388 26.17729  -12.75918 1.000 48.62808 ? 229 ASP A OD2 1 
ATOM   1774 N N   . PHE A 1 229 ? 23.69857 22.41659  -9.66033  1.000 32.46195 ? 230 PHE A N   1 
ATOM   1775 C CA  . PHE A 1 229 ? 22.50690 21.93688  -8.96974  1.000 33.13271 ? 230 PHE A CA  1 
ATOM   1776 C C   . PHE A 1 229 ? 22.82301 21.63758  -7.51431  1.000 30.52860 ? 230 PHE A C   1 
ATOM   1777 O O   . PHE A 1 229 ? 22.10363 22.06485  -6.60419  1.000 29.35382 ? 230 PHE A O   1 
ATOM   1778 C CB  . PHE A 1 229 ? 21.94890 20.69004  -9.65658  1.000 28.30791 ? 230 PHE A CB  1 
ATOM   1779 C CG  . PHE A 1 229 ? 20.83099 20.04398  -8.89229  1.000 30.66031 ? 230 PHE A CG  1 
ATOM   1780 C CD1 . PHE A 1 229 ? 19.52072 20.46046  -9.07986  1.000 30.13232 ? 230 PHE A CD1 1 
ATOM   1781 C CD2 . PHE A 1 229 ? 21.09304 19.04475  -7.95661  1.000 31.99383 ? 230 PHE A CD2 1 
ATOM   1782 C CE1 . PHE A 1 229 ? 18.49520 19.88341  -8.36777  1.000 29.62337 ? 230 PHE A CE1 1 
ATOM   1783 C CE2 . PHE A 1 229 ? 20.06845 18.46614  -7.24569  1.000 30.73375 ? 230 PHE A CE2 1 
ATOM   1784 C CZ  . PHE A 1 229 ? 18.77400 18.88103  -7.44907  1.000 30.95000 ? 230 PHE A CZ  1 
ATOM   1785 N N   . ASN A 1 230 ? 23.91226 20.90647  -7.27929  1.000 32.04831 ? 231 ASN A N   1 
ATOM   1786 C CA  . ASN A 1 230 ? 24.25302 20.50379  -5.92272  1.000 30.72842 ? 231 ASN A CA  1 
ATOM   1787 C C   . ASN A 1 230 ? 24.48715 21.69693  -5.00083  1.000 33.37154 ? 231 ASN A C   1 
ATOM   1788 O O   . ASN A 1 230 ? 24.23169 21.58614  -3.80283  1.000 34.65769 ? 231 ASN A O   1 
ATOM   1789 C CB  . ASN A 1 230 ? 25.47473 19.58934  -5.94285  1.000 28.45916 ? 231 ASN A CB  1 
ATOM   1790 C CG  . ASN A 1 230 ? 25.12047 18.15410  -6.29566  1.000 31.09850 ? 231 ASN A CG  1 
ATOM   1791 O OD1 . ASN A 1 230 ? 24.10246 17.62432  -5.85031  1.000 29.62646 ? 231 ASN A OD1 1 
ATOM   1792 N ND2 . ASN A 1 230 ? 25.95812 17.52180  -7.10377  1.000 30.39712 ? 231 ASN A ND2 1 
ATOM   1793 N N   . LEU A 1 231 ? 24.94885 22.84640  -5.51344  1.000 35.75715 ? 232 LEU A N   1 
ATOM   1794 C CA  . LEU A 1 231 ? 25.11907 23.98978  -4.61222  1.000 36.82910 ? 232 LEU A CA  1 
ATOM   1795 C C   . LEU A 1 231 ? 23.78673 24.44501  -4.03281  1.000 38.95158 ? 232 LEU A C   1 
ATOM   1796 O O   . LEU A 1 231 ? 23.68505 24.74414  -2.83644  1.000 38.84588 ? 232 LEU A O   1 
ATOM   1797 C CB  . LEU A 1 231 ? 25.80027 25.18251  -5.28653  1.000 37.51555 ? 232 LEU A CB  1 
ATOM   1798 C CG  . LEU A 1 231 ? 27.24802 25.30378  -5.79437  1.000 45.30744 ? 232 LEU A CG  1 
ATOM   1799 C CD1 . LEU A 1 231 ? 28.27173 24.55546  -4.93000  1.000 45.69189 ? 232 LEU A CD1 1 
ATOM   1800 C CD2 . LEU A 1 231 ? 27.44976 25.10994  -7.31979  1.000 48.27319 ? 232 LEU A CD2 1 
ATOM   1801 N N   . VAL A 1 232 ? 22.75785 24.53632  -4.87151  1.000 33.70374 ? 233 VAL A N   1 
ATOM   1802 C CA  . VAL A 1 232 ? 21.44829 24.91841  -4.35517  1.000 33.95099 ? 233 VAL A CA  1 
ATOM   1803 C C   . VAL A 1 232 ? 20.88569 23.81722  -3.47278  1.000 34.91360 ? 233 VAL A C   1 
ATOM   1804 O O   . VAL A 1 232 ? 20.35900 24.08404  -2.38713  1.000 37.14446 ? 233 VAL A O   1 
ATOM   1805 C CB  . VAL A 1 232 ? 20.48629 25.25987  -5.50605  1.000 35.82157 ? 233 VAL A CB  1 
ATOM   1806 C CG1 . VAL A 1 232 ? 19.14434 25.71449  -4.95041  1.000 38.26276 ? 233 VAL A CG1 1 
ATOM   1807 C CG2 . VAL A 1 232 ? 21.09543 26.31522  -6.39913  1.000 36.23719 ? 233 VAL A CG2 1 
ATOM   1808 N N   . ALA A 1 233 ? 20.99582 22.56058  -3.91977  1.000 32.34892 ? 234 ALA A N   1 
ATOM   1809 C CA  . ALA A 1 233 ? 20.41275 21.44836  -3.17653  1.000 34.54032 ? 234 ALA A CA  1 
ATOM   1810 C C   . ALA A 1 233 ? 20.87412 21.41769  -1.71916  1.000 33.39694 ? 234 ALA A C   1 
ATOM   1811 O O   . ALA A 1 233 ? 20.06701 21.12596  -0.82706  1.000 34.57819 ? 234 ALA A O   1 
ATOM   1812 C CB  . ALA A 1 233 ? 20.73786 20.12948  -3.87647  1.000 34.46422 ? 234 ALA A CB  1 
ATOM   1813 N N   . MET A 1 234 ? 22.15753 21.72330  -1.44761  1.000 35.20997 ? 235 MET A N   1 
ATOM   1814 C CA  . MET A 1 234 ? 22.65049 21.69145  -0.06482  1.000 38.16361 ? 235 MET A CA  1 
ATOM   1815 C C   . MET A 1 234 ? 21.85092 22.60958  0.84607   1.000 38.33056 ? 235 MET A C   1 
ATOM   1816 O O   . MET A 1 234 ? 21.67363 22.31471  2.03524   1.000 40.42875 ? 235 MET A O   1 
ATOM   1817 C CB  . MET A 1 234 ? 24.11437 22.12110  0.05219   1.000 44.16828 ? 235 MET A CB  1 
ATOM   1818 C CG  . MET A 1 234 ? 25.05273 21.89300  -1.08952  1.000 49.32933 ? 235 MET A CG  1 
ATOM   1819 S SD  . MET A 1 234 ? 26.69988 22.49735  -0.63349  1.000 62.43430 ? 235 MET A SD  1 
ATOM   1820 C CE  . MET A 1 234 ? 27.39632 22.86806  -2.22116  1.000 47.89220 ? 235 MET A CE  1 
ATOM   1821 N N   . LYS A 1 235 ? 21.42270 23.75952  0.32623   1.000 33.09489 ? 236 LYS A N   1 
ATOM   1822 C CA  . LYS A 1 235 ? 20.80868 24.76829  1.17698   1.000 35.98448 ? 236 LYS A CA  1 
ATOM   1823 C C   . LYS A 1 235 ? 19.38902 24.40211  1.55575   1.000 33.52096 ? 236 LYS A C   1 
ATOM   1824 O O   . LYS A 1 235 ? 18.84044 24.98299  2.49832   1.000 35.04129 ? 236 LYS A O   1 
ATOM   1825 C CB  . LYS A 1 235 ? 20.81766 26.14801  0.49737   1.000 39.63497 ? 236 LYS A CB  1 
ATOM   1826 C CG  . LYS A 1 235 ? 21.93604 26.41665  -0.52211  1.000 41.82801 ? 236 LYS A CG  1 
ATOM   1827 C CD  . LYS A 1 235 ? 23.35037 26.07902  -0.02543  1.000 44.60232 ? 236 LYS A CD  1 
ATOM   1828 C CE  . LYS A 1 235 ? 23.67785 26.66831  1.34699   1.000 48.32404 ? 236 LYS A CE  1 
ATOM   1829 N NZ  . LYS A 1 235 ? 24.00490 28.12271  1.29226   1.000 48.53521 ? 236 LYS A NZ  1 
ATOM   1830 N N   . TYR A 1 236 ? 18.78754 23.44988  0.84399   1.000 31.80284 ? 237 TYR A N   1 
ATOM   1831 C CA  . TYR A 1 236 ? 17.44347 22.97290  1.12905   1.000 29.43042 ? 237 TYR A CA  1 
ATOM   1832 C C   . TYR A 1 236 ? 17.45469 21.58579  1.75603   1.000 30.83521 ? 237 TYR A C   1 
ATOM   1833 O O   . TYR A 1 236 ? 16.43417 20.89217  1.73642   1.000 31.69540 ? 237 TYR A O   1 
ATOM   1834 C CB  . TYR A 1 236 ? 16.60595 22.99042  -0.14923  1.000 27.67263 ? 237 TYR A CB  1 
ATOM   1835 C CG  . TYR A 1 236 ? 16.35385 24.40262  -0.62719  1.000 31.04833 ? 237 TYR A CG  1 
ATOM   1836 C CD1 . TYR A 1 236 ? 17.22647 25.02303  -1.52097  1.000 32.07404 ? 237 TYR A CD1 1 
ATOM   1837 C CD2 . TYR A 1 236 ? 15.27014 25.13063  -0.15570  1.000 34.75452 ? 237 TYR A CD2 1 
ATOM   1838 C CE1 . TYR A 1 236 ? 17.00584 26.32377  -1.94721  1.000 33.94585 ? 237 TYR A CE1 1 
ATOM   1839 C CE2 . TYR A 1 236 ? 15.04328 26.43728  -0.57872  1.000 36.26163 ? 237 TYR A CE2 1 
ATOM   1840 C CZ  . TYR A 1 236 ? 15.91608 27.02554  -1.47241  1.000 35.62036 ? 237 TYR A CZ  1 
ATOM   1841 O OH  . TYR A 1 236 ? 15.70101 28.32068  -1.89936  1.000 40.34542 ? 237 TYR A OH  1 
ATOM   1842 N N   . ASN A 1 237 ? 18.59398 21.17781  2.31525   1.000 29.71358 ? 238 ASN A N   1 
ATOM   1843 C CA  . ASN A 1 237 ? 18.72009 19.89741  3.00664   1.000 32.50854 ? 238 ASN A CA  1 
ATOM   1844 C C   . ASN A 1 237 ? 18.43765 18.71904  2.07447   1.000 29.31869 ? 238 ASN A C   1 
ATOM   1845 O O   . ASN A 1 237 ? 17.83697 17.71725  2.47490   1.000 29.97396 ? 238 ASN A O   1 
ATOM   1846 C CB  . ASN A 1 237 ? 17.81221 19.84546  4.23336   1.000 30.46584 ? 238 ASN A CB  1 
ATOM   1847 C CG  . ASN A 1 237 ? 18.37350 18.97499  5.30831   1.000 37.50056 ? 238 ASN A CG  1 
ATOM   1848 O OD1 . ASN A 1 237 ? 19.54153 18.59364  5.25229   1.000 40.33331 ? 238 ASN A OD1 1 
ATOM   1849 N ND2 . ASN A 1 237 ? 17.55470 18.64683  6.30144   1.000 41.07120 ? 238 ASN A ND2 1 
ATOM   1850 N N   . TYR A 1 238 ? 18.87426 18.83337  0.82339   1.000 26.21758 ? 239 TYR A N   1 
ATOM   1851 C CA  . TYR A 1 238 ? 18.78167 17.73323  -0.12549  1.000 27.04290 ? 239 TYR A CA  1 
ATOM   1852 C C   . TYR A 1 238 ? 20.10358 16.98176  -0.16899  1.000 25.99590 ? 239 TYR A C   1 
ATOM   1853 O O   . TYR A 1 238 ? 21.17360 17.59011  -0.08284  1.000 27.89059 ? 239 TYR A O   1 
ATOM   1854 C CB  . TYR A 1 238 ? 18.41428 18.24708  -1.51997  1.000 24.38167 ? 239 TYR A CB  1 
ATOM   1855 C CG  . TYR A 1 238 ? 16.92443 18.34731  -1.76266  1.000 24.34458 ? 239 TYR A CG  1 
ATOM   1856 C CD1 . TYR A 1 238 ? 16.10501 19.09352  -0.91453  1.000 24.77494 ? 239 TYR A CD1 1 
ATOM   1857 C CD2 . TYR A 1 238 ? 16.33728 17.68994  -2.83979  1.000 25.54670 ? 239 TYR A CD2 1 
ATOM   1858 C CE1 . TYR A 1 238 ? 14.73568 19.18193  -1.14347  1.000 26.87119 ? 239 TYR A CE1 1 
ATOM   1859 C CE2 . TYR A 1 238 ? 14.97273 17.76141  -3.07488  1.000 21.82496 ? 239 TYR A CE2 1 
ATOM   1860 C CZ  . TYR A 1 238 ? 14.18099 18.51046  -2.21977  1.000 26.61991 ? 239 TYR A CZ  1 
ATOM   1861 O OH  . TYR A 1 238 ? 12.83367 18.58349  -2.45411  1.000 27.49850 ? 239 TYR A OH  1 
ATOM   1862 N N   . GLU A 1 239 ? 20.02849 15.65351  -0.28972  1.000 24.28082 ? 240 GLU A N   1 
ATOM   1863 C CA  . GLU A 1 239 ? 21.23148 14.85350  -0.45289  1.000 26.40185 ? 240 GLU A CA  1 
ATOM   1864 C C   . GLU A 1 239 ? 21.94578 15.23917  -1.74822  1.000 28.87427 ? 240 GLU A C   1 
ATOM   1865 O O   . GLU A 1 239 ? 21.30455 15.61959  -2.73001  1.000 25.90434 ? 240 GLU A O   1 
ATOM   1866 C CB  . GLU A 1 239 ? 20.89687 13.36026  -0.49473  1.000 27.66831 ? 240 GLU A CB  1 
ATOM   1867 C CG  . GLU A 1 239 ? 20.48899 12.75653  0.83270   1.000 30.28182 ? 240 GLU A CG  1 
ATOM   1868 C CD  . GLU A 1 239 ? 21.65951 12.58178  1.78809   1.000 36.89982 ? 240 GLU A CD  1 
ATOM   1869 O OE1 . GLU A 1 239 ? 21.71814 13.31699  2.79566   1.000 35.57103 ? 240 GLU A OE1 1 
ATOM   1870 O OE2 . GLU A 1 239 ? 22.51364 11.70374  1.54058   1.000 39.30654 ? 240 GLU A OE2 1 
ATOM   1871 N N   . PRO A 1 240 ? 23.27107 15.11973  -1.78795  1.000 29.01793 ? 241 PRO A N   1 
ATOM   1872 C CA  . PRO A 1 240 ? 23.99261 15.36872  -3.04178  1.000 29.93099 ? 241 PRO A CA  1 
ATOM   1873 C C   . PRO A 1 240 ? 23.57939 14.37935  -4.12316  1.000 25.57303 ? 241 PRO A C   1 
ATOM   1874 O O   . PRO A 1 240 ? 23.38232 13.18931  -3.86049  1.000 29.34436 ? 241 PRO A O   1 
ATOM   1875 C CB  . PRO A 1 240 ? 25.46639 15.17136  -2.65837  1.000 33.16739 ? 241 PRO A CB  1 
ATOM   1876 C CG  . PRO A 1 240 ? 25.50740 15.06118  -1.17348  1.000 33.70095 ? 241 PRO A CG  1 
ATOM   1877 C CD  . PRO A 1 240 ? 24.15362 14.63854  -0.71364  1.000 32.38114 ? 241 PRO A CD  1 
ATOM   1878 N N   . LEU A 1 241 ? 23.46423 14.88693  -5.34771  1.000 27.51116 ? 242 LEU A N   1 
ATOM   1879 C CA  . LEU A 1 241 ? 23.22483 14.06354  -6.52228  1.000 28.65565 ? 242 LEU A CA  1 
ATOM   1880 C C   . LEU A 1 241 ? 24.56288 13.67926  -7.14954  1.000 27.91470 ? 242 LEU A C   1 
ATOM   1881 O O   . LEU A 1 241 ? 25.37528 14.54708  -7.47588  1.000 31.79287 ? 242 LEU A O   1 
ATOM   1882 C CB  . LEU A 1 241 ? 22.35708 14.83073  -7.51881  1.000 24.99123 ? 242 LEU A CB  1 
ATOM   1883 C CG  . LEU A 1 241 ? 21.48078 14.12711  -8.54458  1.000 30.16955 ? 242 LEU A CG  1 
ATOM   1884 C CD1 . LEU A 1 241 ? 20.86992 15.19321  -9.39820  1.000 33.24621 ? 242 LEU A CD1 1 
ATOM   1885 C CD2 . LEU A 1 241 ? 22.28724 13.23839  -9.41247  1.000 33.91893 ? 242 LEU A CD2 1 
ATOM   1886 N N   . THR A 1 242 ? 24.77981 12.38578  -7.32926  1.000 29.17183 ? 243 THR A N   1 
ATOM   1887 C CA  . THR A 1 242 ? 26.01908 11.87373  -7.88944  1.000 29.63012 ? 243 THR A CA  1 
ATOM   1888 C C   . THR A 1 242 ? 25.83545 11.51632  -9.36215  1.000 31.33622 ? 243 THR A C   1 
ATOM   1889 O O   . THR A 1 242 ? 24.71956 11.44876  -9.88557  1.000 27.72640 ? 243 THR A O   1 
ATOM   1890 C CB  . THR A 1 242 ? 26.48892 10.64504  -7.10596  1.000 29.11307 ? 243 THR A CB  1 
ATOM   1891 O OG1 . THR A 1 242 ? 25.57017 9.56537   -7.32480  1.000 28.10209 ? 243 THR A OG1 1 
ATOM   1892 C CG2 . THR A 1 242 ? 26.53775 10.95553  -5.60874  1.000 28.69753 ? 243 THR A CG2 1 
ATOM   1893 N N   . GLN A 1 243 ? 26.96059 11.26732  -10.03664 1.000 32.38369 ? 244 GLN A N   1 
ATOM   1894 C CA  . GLN A 1 243 ? 26.87132 10.75523  -11.39838 1.000 32.84068 ? 244 GLN A CA  1 
ATOM   1895 C C   . GLN A 1 243 ? 26.17636 9.39717   -11.43280 1.000 31.34143 ? 244 GLN A C   1 
ATOM   1896 O O   . GLN A 1 243 ? 25.47982 9.08127   -12.40579 1.000 31.34897 ? 244 GLN A O   1 
ATOM   1897 C CB  . GLN A 1 243 ? 28.26257 10.66229  -12.02800 1.000 35.45595 ? 244 GLN A CB  1 
ATOM   1898 C CG  . GLN A 1 243 ? 28.23709 10.29096  -13.51166 1.000 34.73505 ? 244 GLN A CG  1 
ATOM   1899 C CD  . GLN A 1 243 ? 27.33738 11.20290  -14.32723 1.000 35.19647 ? 244 GLN A CD  1 
ATOM   1900 O OE1 . GLN A 1 243 ? 27.39853 12.42882  -14.20243 1.000 35.19489 ? 244 GLN A OE1 1 
ATOM   1901 N NE2 . GLN A 1 243 ? 26.49298 10.60811  -15.17224 1.000 35.55774 ? 244 GLN A NE2 1 
ATOM   1902 N N   . ASP A 1 244 ? 26.34319 8.58529   -10.38684 1.000 30.84270 ? 245 ASP A N   1 
ATOM   1903 C CA  . ASP A 1 244 ? 25.61730 7.31916   -10.33035 1.000 28.40895 ? 245 ASP A CA  1 
ATOM   1904 C C   . ASP A 1 244 ? 24.11392 7.55879   -10.35454 1.000 26.72152 ? 245 ASP A C   1 
ATOM   1905 O O   . ASP A 1 244 ? 23.37337 6.87436   -11.06564 1.000 26.45289 ? 245 ASP A O   1 
ATOM   1906 C CB  . ASP A 1 244 ? 26.00742 6.54194   -9.07831  1.000 33.23462 ? 245 ASP A CB  1 
ATOM   1907 C CG  . ASP A 1 244 ? 27.29833 5.77933   -9.24591  1.000 37.50448 ? 245 ASP A CG  1 
ATOM   1908 O OD1 . ASP A 1 244 ? 27.80879 5.70562   -10.38648 1.000 36.24915 ? 245 ASP A OD1 1 
ATOM   1909 O OD2 . ASP A 1 244 ? 27.80029 5.25733   -8.22783  1.000 41.41792 ? 245 ASP A OD2 1 
ATOM   1910 N N   . HIS A 1 245 ? 23.64641 8.52548   -9.56681  1.000 26.19770 ? 246 HIS A N   1 
ATOM   1911 C CA  . HIS A 1 245 ? 22.22468 8.86030   -9.56317  1.000 25.28240 ? 246 HIS A CA  1 
ATOM   1912 C C   . HIS A 1 245 ? 21.76265 9.32710   -10.93388 1.000 25.38542 ? 246 HIS A C   1 
ATOM   1913 O O   . HIS A 1 245 ? 20.67983 8.94474   -11.39626 1.000 24.98859 ? 246 HIS A O   1 
ATOM   1914 C CB  . HIS A 1 245 ? 21.94472 9.93933   -8.52592  1.000 24.94972 ? 246 HIS A CB  1 
ATOM   1915 C CG  . HIS A 1 245 ? 22.15762 9.49080   -7.12047  1.000 26.42363 ? 246 HIS A CG  1 
ATOM   1916 N ND1 . HIS A 1 245 ? 22.60147 10.34057  -6.12973  1.000 26.92303 ? 246 HIS A ND1 1 
ATOM   1917 C CD2 . HIS A 1 245 ? 21.97894 8.28464   -6.53502  1.000 23.04622 ? 246 HIS A CD2 1 
ATOM   1918 C CE1 . HIS A 1 245 ? 22.68766 9.67599   -4.99111  1.000 26.20744 ? 246 HIS A CE1 1 
ATOM   1919 N NE2 . HIS A 1 245 ? 22.30354 8.43020   -5.20585  1.000 27.00032 ? 246 HIS A NE2 1 
ATOM   1920 N N   . VAL A 1 246 ? 22.55929 10.17771  -11.58865 1.000 23.05159 ? 247 VAL A N   1 
ATOM   1921 C CA  . VAL A 1 246 ? 22.23009 10.60298  -12.94653 1.000 23.09227 ? 247 VAL A CA  1 
ATOM   1922 C C   . VAL A 1 246 ? 22.07313 9.38517   -13.84665 1.000 24.16920 ? 247 VAL A C   1 
ATOM   1923 O O   . VAL A 1 246 ? 21.11538 9.27953   -14.62477 1.000 28.15751 ? 247 VAL A O   1 
ATOM   1924 C CB  . VAL A 1 246 ? 23.30505 11.56314  -13.49078 1.000 25.97540 ? 247 VAL A CB  1 
ATOM   1925 C CG1 . VAL A 1 246 ? 23.08059 11.82358  -14.97325 1.000 26.93392 ? 247 VAL A CG1 1 
ATOM   1926 C CG2 . VAL A 1 246 ? 23.28487 12.88092  -12.74562 1.000 28.33316 ? 247 VAL A CG2 1 
ATOM   1927 N N   . ASP A 1 247 ? 23.01763 8.43933   -13.74861 1.000 25.38618 ? 248 ASP A N   1 
ATOM   1928 C CA  . ASP A 1 247 ? 22.96487 7.24710   -14.59054 1.000 26.88361 ? 248 ASP A CA  1 
ATOM   1929 C C   . ASP A 1 247 ? 21.76071 6.38398   -14.24994 1.000 26.82841 ? 248 ASP A C   1 
ATOM   1930 O O   . ASP A 1 247 ? 21.16033 5.76923   -15.13780 1.000 24.88689 ? 248 ASP A O   1 
ATOM   1931 C CB  . ASP A 1 247 ? 24.24035 6.42267   -14.44228 1.000 27.45352 ? 248 ASP A CB  1 
ATOM   1932 C CG  . ASP A 1 247 ? 25.44990 7.10640   -15.03831 1.000 30.26248 ? 248 ASP A CG  1 
ATOM   1933 O OD1 . ASP A 1 247 ? 25.26768 8.00352   -15.88894 1.000 32.77582 ? 248 ASP A OD1 1 
ATOM   1934 O OD2 . ASP A 1 247 ? 26.57958 6.74079   -14.64949 1.000 35.11436 ? 248 ASP A OD2 1 
ATOM   1935 N N   . ILE A 1 248 ? 21.41044 6.31196   -12.96675 1.000 23.93610 ? 249 ILE A N   1 
ATOM   1936 C CA  . ILE A 1 248 ? 20.25269 5.53659   -12.54033 1.000 26.59283 ? 249 ILE A CA  1 
ATOM   1937 C C   . ILE A 1 248 ? 18.96328 6.13430   -13.08513 1.000 25.89629 ? 249 ILE A C   1 
ATOM   1938 O O   . ILE A 1 248 ? 17.98642 5.41024   -13.31143 1.000 23.49051 ? 249 ILE A O   1 
ATOM   1939 C CB  . ILE A 1 248 ? 20.23165 5.44210   -11.00235 1.000 28.38154 ? 249 ILE A CB  1 
ATOM   1940 C CG1 . ILE A 1 248 ? 21.32309 4.48697   -10.52589 1.000 27.95201 ? 249 ILE A CG1 1 
ATOM   1941 C CG2 . ILE A 1 248 ? 18.87396 4.98111   -10.49567 1.000 28.65072 ? 249 ILE A CG2 1 
ATOM   1942 C CD1 . ILE A 1 248 ? 21.73141 4.72365   -9.08331  1.000 25.90680 ? 249 ILE A CD1 1 
ATOM   1943 N N   . LEU A 1 249 ? 18.92527 7.44822   -13.30393 1.000 21.24366 ? 250 LEU A N   1 
ATOM   1944 C CA  . LEU A 1 249 ? 17.73269 8.08150   -13.86102 1.000 22.96809 ? 250 LEU A CA  1 
ATOM   1945 C C   . LEU A 1 249 ? 17.65796 7.97924   -15.37824 1.000 23.72483 ? 250 LEU A C   1 
ATOM   1946 O O   . LEU A 1 249 ? 16.66894 8.42957   -15.96459 1.000 26.49913 ? 250 LEU A O   1 
ATOM   1947 C CB  . LEU A 1 249 ? 17.66950 9.55666   -13.44173 1.000 21.79639 ? 250 LEU A CB  1 
ATOM   1948 C CG  . LEU A 1 249 ? 17.36452 9.79115   -11.95372 1.000 19.35236 ? 250 LEU A CG  1 
ATOM   1949 C CD1 . LEU A 1 249 ? 17.80547 11.17509  -11.51423 1.000 18.64761 ? 250 LEU A CD1 1 
ATOM   1950 C CD2 . LEU A 1 249 ? 15.88118 9.61555   -11.68841 1.000 21.39153 ? 250 LEU A CD2 1 
ATOM   1951 N N   . GLY A 1 250 ? 18.66567 7.39322   -16.01593 1.000 24.46315 ? 251 GLY A N   1 
ATOM   1952 C CA  . GLY A 1 250 ? 18.69810 7.21277   -17.44739 1.000 25.71734 ? 251 GLY A CA  1 
ATOM   1953 C C   . GLY A 1 250 ? 17.41793 6.68532   -18.07006 1.000 27.49524 ? 251 GLY A C   1 
ATOM   1954 O O   . GLY A 1 250 ? 16.88596 7.29216   -19.00302 1.000 28.92708 ? 251 GLY A O   1 
ATOM   1955 N N   . PRO A 1 251 ? 16.89762 5.54360   -17.58613 1.000 26.41202 ? 252 PRO A N   1 
ATOM   1956 C CA  . PRO A 1 251 ? 15.66375 5.00429   -18.19947 1.000 29.17971 ? 252 PRO A CA  1 
ATOM   1957 C C   . PRO A 1 251 ? 14.51057 5.98586   -18.20950 1.000 27.09096 ? 252 PRO A C   1 
ATOM   1958 O O   . PRO A 1 251 ? 13.82554 6.11279   -19.22916 1.000 25.13342 ? 252 PRO A O   1 
ATOM   1959 C CB  . PRO A 1 251 ? 15.33776 3.77637   -17.33664 1.000 28.74384 ? 252 PRO A CB  1 
ATOM   1960 C CG  . PRO A 1 251 ? 16.63794 3.35014   -16.76263 1.000 24.62737 ? 252 PRO A CG  1 
ATOM   1961 C CD  . PRO A 1 251 ? 17.49279 4.60215   -16.61969 1.000 26.71499 ? 252 PRO A CD  1 
ATOM   1962 N N   . LEU A 1 252 ? 14.26654 6.67602   -17.09306 1.000 26.22442 ? 253 LEU A N   1 
ATOM   1963 C CA  . LEU A 1 252 ? 13.15954 7.62041   -17.04277 1.000 24.36619 ? 253 LEU A CA  1 
ATOM   1964 C C   . LEU A 1 252 ? 13.40957 8.78922   -17.98177 1.000 27.22520 ? 253 LEU A C   1 
ATOM   1965 O O   . LEU A 1 252 ? 12.49303 9.24896   -18.67787 1.000 27.55410 ? 253 LEU A O   1 
ATOM   1966 C CB  . LEU A 1 252 ? 12.94855 8.10772   -15.60647 1.000 23.57624 ? 253 LEU A CB  1 
ATOM   1967 C CG  . LEU A 1 252 ? 12.42253 7.04461   -14.63084 1.000 25.84811 ? 253 LEU A CG  1 
ATOM   1968 C CD1 . LEU A 1 252 ? 12.54571 7.49675   -13.16964 1.000 21.36678 ? 253 LEU A CD1 1 
ATOM   1969 C CD2 . LEU A 1 252 ? 10.98812 6.67397   -14.96931 1.000 29.08683 ? 253 LEU A CD2 1 
ATOM   1970 N N   . SER A 1 253 ? 14.64845 9.28065   -18.01486 1.000 26.04189 ? 254 SER A N   1 
ATOM   1971 C CA  . SER A 1 253 ? 15.00430 10.33082  -18.96092 1.000 27.07038 ? 254 SER A CA  1 
ATOM   1972 C C   . SER A 1 253 ? 14.74895 9.89019   -20.40115 1.000 28.89328 ? 254 SER A C   1 
ATOM   1973 O O   . SER A 1 253 ? 14.21163 10.65673  -21.20866 1.000 32.23632 ? 254 SER A O   1 
ATOM   1974 C CB  . SER A 1 253 ? 16.46587 10.71166  -18.75952 1.000 25.98017 ? 254 SER A CB  1 
ATOM   1975 O OG  . SER A 1 253 ? 16.86253 11.68159  -19.69620 1.000 32.16914 ? 254 SER A OG  1 
ATOM   1976 N N   . ALA A 1 254 ? 15.12126 8.65652   -20.74399 1.000 30.55556 ? 255 ALA A N   1 
ATOM   1977 C CA  . ALA A 1 254 ? 14.91385 8.19318   -22.11450 1.000 33.61331 ? 255 ALA A CA  1 
ATOM   1978 C C   . ALA A 1 254 ? 13.43277 8.08071   -22.44820 1.000 32.11046 ? 255 ALA A C   1 
ATOM   1979 O O   . ALA A 1 254 ? 13.02574 8.34898   -23.58609 1.000 31.63712 ? 255 ALA A O   1 
ATOM   1980 C CB  . ALA A 1 254 ? 15.60919 6.84607   -22.33325 1.000 32.58817 ? 255 ALA A CB  1 
ATOM   1981 N N   . GLN A 1 255 ? 12.61065 7.66491   -21.48167 1.000 29.00566 ? 256 GLN A N   1 
ATOM   1982 C CA  . GLN A 1 255 ? 11.18710 7.48825   -21.75979 1.000 31.35698 ? 256 GLN A CA  1 
ATOM   1983 C C   . GLN A 1 255 ? 10.48824 8.82180   -21.99450 1.000 36.50209 ? 256 GLN A C   1 
ATOM   1984 O O   . GLN A 1 255 ? 9.59188  8.91990   -22.84191 1.000 33.80124 ? 256 GLN A O   1 
ATOM   1985 C CB  . GLN A 1 255 ? 10.52434 6.74213   -20.60937 1.000 32.62151 ? 256 GLN A CB  1 
ATOM   1986 C CG  . GLN A 1 255 ? 9.01901  6.90077   -20.53246 1.000 34.79052 ? 256 GLN A CG  1 
ATOM   1987 C CD  . GLN A 1 255 ? 8.43975  6.04520   -19.43530 1.000 39.11638 ? 256 GLN A CD  1 
ATOM   1988 O OE1 . GLN A 1 255 ? 9.17111  5.57741   -18.55784 1.000 43.37416 ? 256 GLN A OE1 1 
ATOM   1989 N NE2 . GLN A 1 255 ? 7.12858  5.82054   -19.47644 1.000 39.22970 ? 256 GLN A NE2 1 
ATOM   1990 N N   . THR A 1 256 ? 10.86422 9.85557   -21.24679 1.000 28.67582 ? 257 THR A N   1 
ATOM   1991 C CA  . THR A 1 256 ? 10.17174 11.13370  -21.33860 1.000 30.42627 ? 257 THR A CA  1 
ATOM   1992 C C   . THR A 1 256 ? 10.85521 12.12548  -22.26303 1.000 29.42413 ? 257 THR A C   1 
ATOM   1993 O O   . THR A 1 256 ? 10.26404 13.16365  -22.56526 1.000 32.65799 ? 257 THR A O   1 
ATOM   1994 C CB  . THR A 1 256 ? 10.02676 11.79615  -19.96136 1.000 30.21356 ? 257 THR A CB  1 
ATOM   1995 O OG1 . THR A 1 256 ? 11.32558 12.03017  -19.40085 1.000 31.27110 ? 257 THR A OG1 1 
ATOM   1996 C CG2 . THR A 1 256 ? 9.18916  10.94193  -19.01541 1.000 28.73755 ? 257 THR A CG2 1 
ATOM   1997 N N   . GLY A 1 257 ? 12.07569 11.84821  -22.70194 1.000 29.69366 ? 258 GLY A N   1 
ATOM   1998 C CA  . GLY A 1 257 ? 12.78236 12.81282  -23.51420 1.000 29.67474 ? 258 GLY A CA  1 
ATOM   1999 C C   . GLY A 1 257 ? 13.28646 14.02542  -22.76868 1.000 32.36044 ? 258 GLY A C   1 
ATOM   2000 O O   . GLY A 1 257 ? 13.59456 15.03605  -23.39823 1.000 30.12344 ? 258 GLY A O   1 
ATOM   2001 N N   . ILE A 1 258 ? 13.38578 13.95944  -21.44384 1.000 25.56789 ? 259 ILE A N   1 
ATOM   2002 C CA  . ILE A 1 258 ? 13.88132 15.06771  -20.63219 1.000 24.52379 ? 259 ILE A CA  1 
ATOM   2003 C C   . ILE A 1 258 ? 15.21040 14.62841  -20.04176 1.000 28.73085 ? 259 ILE A C   1 
ATOM   2004 O O   . ILE A 1 258 ? 15.26848 13.65512  -19.27704 1.000 26.62429 ? 259 ILE A O   1 
ATOM   2005 C CB  . ILE A 1 258 ? 12.88824 15.45726  -19.53255 1.000 23.24232 ? 259 ILE A CB  1 
ATOM   2006 C CG1 . ILE A 1 258 ? 11.52844 15.77503  -20.13933 1.000 27.62386 ? 259 ILE A CG1 1 
ATOM   2007 C CG2 . ILE A 1 258 ? 13.43144 16.60567  -18.68902 1.000 27.30436 ? 259 ILE A CG2 1 
ATOM   2008 C CD1 . ILE A 1 258 ? 10.41284 15.75601  -19.14221 1.000 28.69339 ? 259 ILE A CD1 1 
ATOM   2009 N N   . ALA A 1 259 ? 16.28537 15.31500  -20.42675 1.000 27.66177 ? 260 ALA A N   1 
ATOM   2010 C CA  . ALA A 1 259 ? 17.59440 15.00719  -19.87158 1.000 28.09615 ? 260 ALA A CA  1 
ATOM   2011 C C   . ALA A 1 259 ? 17.56783 15.16223  -18.35950 1.000 27.22914 ? 260 ALA A C   1 
ATOM   2012 O O   . ALA A 1 259 ? 16.82152 15.97688  -17.80605 1.000 25.52693 ? 260 ALA A O   1 
ATOM   2013 C CB  . ALA A 1 259 ? 18.66680 15.91517  -20.47191 1.000 31.99375 ? 260 ALA A CB  1 
ATOM   2014 N N   . VAL A 1 260 ? 18.38755 14.35349  -17.68793 1.000 30.00616 ? 261 VAL A N   1 
ATOM   2015 C CA  . VAL A 1 260 ? 18.41858 14.37345  -16.22933 1.000 24.26683 ? 261 VAL A CA  1 
ATOM   2016 C C   . VAL A 1 260 ? 18.74887 15.76708  -15.72877 1.000 27.26627 ? 261 VAL A C   1 
ATOM   2017 O O   . VAL A 1 260 ? 18.08477 16.29558  -14.83065 1.000 25.57822 ? 261 VAL A O   1 
ATOM   2018 C CB  . VAL A 1 260 ? 19.42166 13.33218  -15.70378 1.000 23.11754 ? 261 VAL A CB  1 
ATOM   2019 C CG1 . VAL A 1 260 ? 19.62669 13.49735  -14.22832 1.000 26.01365 ? 261 VAL A CG1 1 
ATOM   2020 C CG2 . VAL A 1 260 ? 18.92253 11.93062  -16.04578 1.000 27.45045 ? 261 VAL A CG2 1 
ATOM   2021 N N   . LEU A 1 261 ? 19.78059 16.39141  -16.30432 1.000 29.41721 ? 262 LEU A N   1 
ATOM   2022 C CA  . LEU A 1 261 ? 20.15034 17.72187  -15.83655 1.000 28.29605 ? 262 LEU A CA  1 
ATOM   2023 C C   . LEU A 1 261 ? 19.08672 18.76193  -16.16366 1.000 27.45736 ? 262 LEU A C   1 
ATOM   2024 O O   . LEU A 1 261 ? 19.01923 19.78497  -15.47635 1.000 26.35889 ? 262 LEU A O   1 
ATOM   2025 C CB  . LEU A 1 261 ? 21.50850 18.14431  -16.41300 1.000 29.77636 ? 262 LEU A CB  1 
ATOM   2026 C CG  . LEU A 1 261 ? 22.69956 17.31016  -15.91635 1.000 31.31977 ? 262 LEU A CG  1 
ATOM   2027 C CD1 . LEU A 1 261 ? 24.01841 17.88146  -16.41802 1.000 35.35558 ? 262 LEU A CD1 1 
ATOM   2028 C CD2 . LEU A 1 261 ? 22.71405 17.22823  -14.39673 1.000 33.41987 ? 262 LEU A CD2 1 
ATOM   2029 N N   . ASP A 1 262 ? 18.24355 18.52220  -17.17501 1.000 27.07127 ? 263 ASP A N   1 
ATOM   2030 C CA  . ASP A 1 262 ? 17.12597 19.43522  -17.40239 1.000 29.21328 ? 263 ASP A CA  1 
ATOM   2031 C C   . ASP A 1 262 ? 16.07412 19.27480  -16.31354 1.000 27.76195 ? 263 ASP A C   1 
ATOM   2032 O O   . ASP A 1 262 ? 15.49448 20.26024  -15.85251 1.000 27.76069 ? 263 ASP A O   1 
ATOM   2033 C CB  . ASP A 1 262 ? 16.48649 19.19953  -18.77114 1.000 28.52370 ? 263 ASP A CB  1 
ATOM   2034 C CG  . ASP A 1 262 ? 17.44901 19.42537  -19.93040 1.000 36.66166 ? 263 ASP A CG  1 
ATOM   2035 O OD1 . ASP A 1 262 ? 18.65646 19.63712  -19.69451 1.000 35.39466 ? 263 ASP A OD1 1 
ATOM   2036 O OD2 . ASP A 1 262 ? 16.98620 19.38436  -21.09073 1.000 36.68764 ? 263 ASP A OD2 1 
ATOM   2037 N N   . MET A 1 263 ? 15.78739 18.03617  -15.90711 1.000 24.89553 ? 264 MET A N   1 
ATOM   2038 C CA  . MET A 1 263 ? 14.90946 17.86171  -14.75702 1.000 26.05804 ? 264 MET A CA  1 
ATOM   2039 C C   . MET A 1 263 ? 15.51759 18.50539  -13.51561 1.000 24.16776 ? 264 MET A C   1 
ATOM   2040 O O   . MET A 1 263 ? 14.80877 19.13255  -12.72328 1.000 25.30904 ? 264 MET A O   1 
ATOM   2041 C CB  . MET A 1 263 ? 14.63207 16.37998  -14.51666 1.000 24.17744 ? 264 MET A CB  1 
ATOM   2042 C CG  . MET A 1 263 ? 13.48332 16.13053  -13.55056 1.000 26.76765 ? 264 MET A CG  1 
ATOM   2043 S SD  . MET A 1 263 ? 11.89189 16.78072  -14.12501 1.000 26.49221 ? 264 MET A SD  1 
ATOM   2044 C CE  . MET A 1 263 ? 11.37063 15.51250  -15.28351 1.000 26.45734 ? 264 MET A CE  1 
ATOM   2045 N N   . CYS A 1 264 ? 16.83846 18.38450  -13.35038 1.000 28.36475 ? 265 CYS A N   1 
ATOM   2046 C CA  . CYS A 1 264 ? 17.50397 19.02563  -12.21644 1.000 26.55796 ? 265 CYS A CA  1 
ATOM   2047 C C   . CYS A 1 264 ? 17.28860 20.52794  -12.22992 1.000 24.69742 ? 265 CYS A C   1 
ATOM   2048 O O   . CYS A 1 264 ? 17.10307 21.14102  -11.17457 1.000 26.35644 ? 265 CYS A O   1 
ATOM   2049 C CB  . CYS A 1 264 ? 18.99398 18.71427  -12.22821 1.000 25.89970 ? 265 CYS A CB  1 
ATOM   2050 S SG  . CYS A 1 264 ? 19.37905 17.00694  -11.79134 1.000 29.93866 ? 265 CYS A SG  1 
ATOM   2051 N N   . ALA A 1 265 ? 17.30348 21.14129  -13.41795 1.000 27.95976 ? 266 ALA A N   1 
ATOM   2052 C CA  . ALA A 1 265 ? 17.05745 22.58176  -13.47968 1.000 25.45928 ? 266 ALA A CA  1 
ATOM   2053 C C   . ALA A 1 265 ? 15.63288 22.91148  -13.05154 1.000 27.99615 ? 266 ALA A C   1 
ATOM   2054 O O   . ALA A 1 265 ? 15.39398 23.93872  -12.40050 1.000 26.80875 ? 266 ALA A O   1 
ATOM   2055 C CB  . ALA A 1 265 ? 17.34401 23.10711  -14.88645 1.000 34.06687 ? 266 ALA A CB  1 
ATOM   2056 N N   . SER A 1 266 ? 14.67176 22.03806  -13.39322 1.000 25.71430 ? 267 SER A N   1 
ATOM   2057 C CA  . SER A 1 266 ? 13.29132 22.24267  -12.96046 1.000 25.09222 ? 267 SER A CA  1 
ATOM   2058 C C   . SER A 1 266 ? 13.16168 22.11503  -11.45067 1.000 27.03545 ? 267 SER A C   1 
ATOM   2059 O O   . SER A 1 266 ? 12.46594 22.91022  -10.81370 1.000 28.85938 ? 267 SER A O   1 
ATOM   2060 C CB  . SER A 1 266 ? 12.35933 21.24815  -13.66161 1.000 26.37926 ? 267 SER A CB  1 
ATOM   2061 O OG  . SER A 1 266 ? 12.27223 21.53578  -15.04697 1.000 30.73649 ? 267 SER A OG  1 
ATOM   2062 N N   . LEU A 1 267 ? 13.81229 21.11052  -10.86063 1.000 24.23462 ? 268 LEU A N   1 
ATOM   2063 C CA  . LEU A 1 267 ? 13.78487 20.98116  -9.41012  1.000 22.83469 ? 268 LEU A CA  1 
ATOM   2064 C C   . LEU A 1 267 ? 14.44138 22.18184  -8.74003  1.000 26.57906 ? 268 LEU A C   1 
ATOM   2065 O O   . LEU A 1 267 ? 13.95893 22.66193  -7.71127  1.000 30.81349 ? 268 LEU A O   1 
ATOM   2066 C CB  . LEU A 1 267 ? 14.47367 19.68365  -8.98233  1.000 26.43634 ? 268 LEU A CB  1 
ATOM   2067 C CG  . LEU A 1 267 ? 14.59678 19.48397  -7.46687  1.000 20.89646 ? 268 LEU A CG  1 
ATOM   2068 C CD1 . LEU A 1 267 ? 13.24148 19.47321  -6.81177  1.000 21.69463 ? 268 LEU A CD1 1 
ATOM   2069 C CD2 . LEU A 1 267 ? 15.33771 18.17913  -7.16684  1.000 28.02053 ? 268 LEU A CD2 1 
ATOM   2070 N N   . LYS A 1 268 ? 15.53181 22.69330  -9.31640  1.000 26.54344 ? 269 LYS A N   1 
ATOM   2071 C CA  . LYS A 1 268 ? 16.19350 23.85430  -8.71715  1.000 31.56301 ? 269 LYS A CA  1 
ATOM   2072 C C   . LYS A 1 268 ? 15.24047 25.04288  -8.61832  1.000 30.00077 ? 269 LYS A C   1 
ATOM   2073 O O   . LYS A 1 268 ? 15.19959 25.73084  -7.59454  1.000 34.28525 ? 269 LYS A O   1 
ATOM   2074 C CB  . LYS A 1 268 ? 17.44273 24.21710  -9.52045  1.000 31.23314 ? 269 LYS A CB  1 
ATOM   2075 C CG  . LYS A 1 268 ? 18.03278 25.59140  -9.20023  1.000 40.79949 ? 269 LYS A CG  1 
ATOM   2076 C CD  . LYS A 1 268 ? 19.26889 25.87195  -10.04562 1.000 34.54724 ? 269 LYS A CD  1 
ATOM   2077 C CE  . LYS A 1 268 ? 18.87507 26.47591  -11.39239 1.000 40.13119 ? 269 LYS A CE  1 
ATOM   2078 N NZ  . LYS A 1 268 ? 19.99367 26.41293  -12.38061 1.000 45.95064 ? 269 LYS A NZ  1 
ATOM   2079 N N   . GLU A 1 269 ? 14.43979 25.27971  -9.65703  1.000 29.87100 ? 270 GLU A N   1 
ATOM   2080 C CA  . GLU A 1 269 ? 13.47711 26.37747  -9.59906  1.000 32.90328 ? 270 GLU A CA  1 
ATOM   2081 C C   . GLU A 1 269 ? 12.35905 26.09005  -8.60319  1.000 32.82899 ? 270 GLU A C   1 
ATOM   2082 O O   . GLU A 1 269 ? 11.88771 27.00272  -7.91276  1.000 36.08072 ? 270 GLU A O   1 
ATOM   2083 C CB  . GLU A 1 269 ? 12.89684 26.65644  -10.98758 1.000 34.73006 ? 270 GLU A CB  1 
ATOM   2084 C CG  . GLU A 1 269 ? 11.52732 27.33162  -10.93422 1.000 40.10465 ? 270 GLU A CG  1 
ATOM   2085 C CD  . GLU A 1 269 ? 11.05061 27.85175  -12.27824 1.000 48.82384 ? 270 GLU A CD  1 
ATOM   2086 O OE1 . GLU A 1 269 ? 10.09341 28.65886  -12.28215 1.000 49.88530 ? 270 GLU A OE1 1 
ATOM   2087 O OE2 . GLU A 1 269 ? 11.61711 27.45019  -13.32382 1.000 44.61180 ? 270 GLU A OE2 1 
ATOM   2088 N N   . LEU A 1 270 ? 11.90898 24.83332  -8.51921  1.000 29.36490 ? 271 LEU A N   1 
ATOM   2089 C CA  . LEU A 1 270 ? 10.86591 24.49333  -7.55429  1.000 28.03300 ? 271 LEU A CA  1 
ATOM   2090 C C   . LEU A 1 270 ? 11.33717 24.73587  -6.12872  1.000 30.04959 ? 271 LEU A C   1 
ATOM   2091 O O   . LEU A 1 270 ? 10.56444 25.20019  -5.28586  1.000 33.77430 ? 271 LEU A O   1 
ATOM   2092 C CB  . LEU A 1 270 ? 10.43642 23.03396  -7.71368  1.000 26.62612 ? 271 LEU A CB  1 
ATOM   2093 C CG  . LEU A 1 270 ? 9.52985  22.68248  -8.88565  1.000 29.49283 ? 271 LEU A CG  1 
ATOM   2094 C CD1 . LEU A 1 270 ? 9.38885  21.16117  -9.01667  1.000 26.90012 ? 271 LEU A CD1 1 
ATOM   2095 C CD2 . LEU A 1 270 ? 8.17754  23.33583  -8.66474  1.000 31.74574 ? 271 LEU A CD2 1 
ATOM   2096 N N   . LEU A 1 271 ? 12.59917 24.41026  -5.83860  1.000 28.79712 ? 272 LEU A N   1 
ATOM   2097 C CA  . LEU A 1 271 ? 13.13605 24.63159  -4.49749  1.000 26.87928 ? 272 LEU A CA  1 
ATOM   2098 C C   . LEU A 1 271 ? 13.20518 26.11434  -4.16500  1.000 33.53349 ? 272 LEU A C   1 
ATOM   2099 O O   . LEU A 1 271 ? 12.90097 26.52157  -3.03799  1.000 34.52721 ? 272 LEU A O   1 
ATOM   2100 C CB  . LEU A 1 271 ? 14.52024 23.99841  -4.37943  1.000 30.61060 ? 272 LEU A CB  1 
ATOM   2101 C CG  . LEU A 1 271 ? 14.55058 22.46686  -4.36990  1.000 25.56503 ? 272 LEU A CG  1 
ATOM   2102 C CD1 . LEU A 1 271 ? 15.97085 21.95820  -4.26200  1.000 25.76639 ? 272 LEU A CD1 1 
ATOM   2103 C CD2 . LEU A 1 271 ? 13.67352 21.89666  -3.26483  1.000 27.58786 ? 272 LEU A CD2 1 
ATOM   2104 N N   . GLN A 1 272 ? 13.59167 26.93800  -5.13323  1.000 34.69755 ? 273 GLN A N   1 
ATOM   2105 C CA  . GLN A 1 272 ? 13.74578 28.35735  -4.85682  1.000 38.03640 ? 273 GLN A CA  1 
ATOM   2106 C C   . GLN A 1 272 ? 12.42130 29.11364  -4.82941  1.000 40.05068 ? 273 GLN A C   1 
ATOM   2107 O O   . GLN A 1 272 ? 12.34368 30.15481  -4.16664  1.000 40.95725 ? 273 GLN A O   1 
ATOM   2108 C CB  . GLN A 1 272 ? 14.68932 28.97741  -5.88025  1.000 37.70972 ? 273 GLN A CB  1 
ATOM   2109 C CG  . GLN A 1 272 ? 16.10405 28.45372  -5.75622  1.000 38.65997 ? 273 GLN A CG  1 
ATOM   2110 C CD  . GLN A 1 272 ? 16.93736 28.75140  -6.97913  1.000 40.63117 ? 273 GLN A CD  1 
ATOM   2111 O OE1 . GLN A 1 272 ? 16.40761 29.05734  -8.05214  1.000 46.80734 ? 273 GLN A OE1 1 
ATOM   2112 N NE2 . GLN A 1 272 ? 18.25078 28.68277  -6.82461  1.000 40.96415 ? 273 GLN A NE2 1 
ATOM   2113 N N   . ASN A 1 273 ? 11.37639 28.61737  -5.50913  1.000 40.00344 ? 274 ASN A N   1 
ATOM   2114 C CA  . ASN A 1 273 ? 10.11269 29.34138  -5.60115  1.000 39.24587 ? 274 ASN A CA  1 
ATOM   2115 C C   . ASN A 1 273 ? 8.91890  28.65696  -4.95392  1.000 42.19837 ? 274 ASN A C   1 
ATOM   2116 O O   . ASN A 1 273 ? 7.85481  29.28188  -4.87672  1.000 43.87048 ? 274 ASN A O   1 
ATOM   2117 C CB  . ASN A 1 273 ? 9.72632  29.61128  -7.06524  1.000 46.22864 ? 274 ASN A CB  1 
ATOM   2118 C CG  . ASN A 1 273 ? 10.87525 30.11930  -7.90488  1.000 47.49152 ? 274 ASN A CG  1 
ATOM   2119 O OD1 . ASN A 1 273 ? 11.88798 30.58895  -7.39020  1.000 51.89209 ? 274 ASN A OD1 1 
ATOM   2120 N ND2 . ASN A 1 273 ? 10.71648 30.03213  -9.21885  1.000 49.08443 ? 274 ASN A ND2 1 
ATOM   2121 N N   . GLY A 1 274 ? 9.03174  27.40287  -4.52243  1.000 40.94113 ? 275 GLY A N   1 
ATOM   2122 C CA  . GLY A 1 274 ? 7.85979  26.68011  -4.05839  1.000 38.01847 ? 275 GLY A CA  1 
ATOM   2123 C C   . GLY A 1 274 ? 6.88587  26.43708  -5.20395  1.000 42.98833 ? 275 GLY A C   1 
ATOM   2124 O O   . GLY A 1 274 ? 7.15877  26.72607  -6.36626  1.000 44.67171 ? 275 GLY A O   1 
ATOM   2125 N N   . MET A 1 275 ? 5.72182  25.89072  -4.85658  1.000 41.91664 ? 276 MET A N   1 
ATOM   2126 C CA  . MET A 1 275 ? 4.74085  25.46579  -5.84882  1.000 44.90211 ? 276 MET A CA  1 
ATOM   2127 C C   . MET A 1 275 ? 3.62326  26.47759  -6.07371  1.000 47.93502 ? 276 MET A C   1 
ATOM   2128 O O   . MET A 1 275 ? 2.72078  26.20414  -6.86910  1.000 46.09811 ? 276 MET A O   1 
ATOM   2129 C CB  . MET A 1 275 ? 4.12800  24.11695  -5.44980  1.000 43.23148 ? 276 MET A CB  1 
ATOM   2130 C CG  . MET A 1 275 ? 5.00205  22.90574  -5.75216  1.000 42.09707 ? 276 MET A CG  1 
ATOM   2131 S SD  . MET A 1 275 ? 4.17328  21.35704  -5.33553  1.000 50.42713 ? 276 MET A SD  1 
ATOM   2132 C CE  . MET A 1 275 ? 5.43935  20.61797  -4.32028  1.000 35.87161 ? 276 MET A CE  1 
ATOM   2133 N N   . ASN A 1 276 ? 3.64561  27.61805  -5.37721  1.000 48.81876 ? 277 ASN A N   1 
ATOM   2134 C CA  . ASN A 1 276 ? 2.65066  28.68406  -5.54724  1.000 50.14959 ? 277 ASN A CA  1 
ATOM   2135 C C   . ASN A 1 276 ? 1.21322  28.17149  -5.42730  1.000 48.89955 ? 277 ASN A C   1 
ATOM   2136 O O   . ASN A 1 276 ? 0.30237  28.67545  -6.08936  1.000 50.75313 ? 277 ASN A O   1 
ATOM   2137 C CB  . ASN A 1 276 ? 2.85257  29.40888  -6.88161  1.000 53.19891 ? 277 ASN A CB  1 
ATOM   2138 C CG  . ASN A 1 276 ? 3.22450  30.87230  -6.70006  1.000 60.02309 ? 277 ASN A CG  1 
ATOM   2139 O OD1 . ASN A 1 276 ? 2.74378  31.53690  -5.78038  1.000 58.86375 ? 277 ASN A OD1 1 
ATOM   2140 N ND2 . ASN A 1 276 ? 4.09266  31.37801  -7.57260  1.000 60.51942 ? 277 ASN A ND2 1 
ATOM   2141 N N   . GLY A 1 277 ? 0.99079  27.17370  -4.57485  1.000 47.27493 ? 278 GLY A N   1 
ATOM   2142 C CA  . GLY A 1 277 ? -0.33181 26.61558  -4.40179  1.000 43.92630 ? 278 GLY A CA  1 
ATOM   2143 C C   . GLY A 1 277 ? -0.73856 25.59770  -5.43948  1.000 44.77886 ? 278 GLY A C   1 
ATOM   2144 O O   . GLY A 1 277 ? -1.84932 25.05768  -5.35169  1.000 44.88319 ? 278 GLY A O   1 
ATOM   2145 N N   . ARG A 1 278 ? 0.11141  25.32822  -6.42404  1.000 43.70550 ? 279 ARG A N   1 
ATOM   2146 C CA  . ARG A 1 278 ? -0.12836 24.24302  -7.35657  1.000 41.17408 ? 279 ARG A CA  1 
ATOM   2147 C C   . ARG A 1 278 ? 0.32208  22.92147  -6.74082  1.000 43.89878 ? 279 ARG A C   1 
ATOM   2148 O O   . ARG A 1 278 ? 1.00640  22.88061  -5.71696  1.000 44.56627 ? 279 ARG A O   1 
ATOM   2149 C CB  . ARG A 1 278 ? 0.59716  24.50118  -8.67827  1.000 43.24219 ? 279 ARG A CB  1 
ATOM   2150 C CG  . ARG A 1 278 ? 0.64542  25.97509  -9.08435  1.000 43.88581 ? 279 ARG A CG  1 
ATOM   2151 C CD  . ARG A 1 278 ? 1.32263  26.16462  -10.43092 1.000 37.81797 ? 279 ARG A CD  1 
ATOM   2152 N NE  . ARG A 1 278 ? 0.51151  25.58693  -11.49650 1.000 41.31540 ? 279 ARG A NE  1 
ATOM   2153 C CZ  . ARG A 1 278 ? 0.87532  25.52704  -12.77316 1.000 43.96642 ? 279 ARG A CZ  1 
ATOM   2154 N NH1 . ARG A 1 278 ? 0.05752  24.98336  -13.67252 1.000 40.72720 ? 279 ARG A NH1 1 
ATOM   2155 N NH2 . ARG A 1 278 ? 2.05147  26.01786  -13.15051 1.000 41.02119 ? 279 ARG A NH2 1 
ATOM   2156 N N   . THR A 1 279 ? -0.08632 21.82731  -7.36714  1.000 43.21856 ? 280 THR A N   1 
ATOM   2157 C CA  . THR A 1 279 ? 0.28168  20.50045  -6.91475  1.000 39.76698 ? 280 THR A CA  1 
ATOM   2158 C C   . THR A 1 279 ? 0.98703  19.74748  -8.03192  1.000 40.56796 ? 280 THR A C   1 
ATOM   2159 O O   . THR A 1 279 ? 0.83416  20.05088  -9.21871  1.000 35.63557 ? 280 THR A O   1 
ATOM   2160 C CB  . THR A 1 279 ? -0.94074 19.69482  -6.45264  1.000 40.12590 ? 280 THR A CB  1 
ATOM   2161 O OG1 . THR A 1 279 ? -1.68694 19.25440  -7.59547  1.000 42.38042 ? 280 THR A OG1 1 
ATOM   2162 C CG2 . THR A 1 279 ? -1.82088 20.53800  -5.55689  1.000 40.07582 ? 280 THR A CG2 1 
ATOM   2163 N N   . ILE A 1 280 ? 1.76711  18.75130  -7.62971  1.000 32.90615 ? 281 ILE A N   1 
ATOM   2164 C CA  . ILE A 1 280 ? 2.37692  17.80768  -8.54808  1.000 32.12352 ? 281 ILE A CA  1 
ATOM   2165 C C   . ILE A 1 280 ? 1.88395  16.42708  -8.14521  1.000 35.58147 ? 281 ILE A C   1 
ATOM   2166 O O   . ILE A 1 280 ? 2.01473  16.03989  -6.97663  1.000 34.17793 ? 281 ILE A O   1 
ATOM   2167 C CB  . ILE A 1 280 ? 3.90922  17.88377  -8.51369  1.000 27.10642 ? 281 ILE A CB  1 
ATOM   2168 C CG1 . ILE A 1 280 ? 4.39045  19.26143  -8.96991  1.000 30.83901 ? 281 ILE A CG1 1 
ATOM   2169 C CG2 . ILE A 1 280 ? 4.50515  16.78944  -9.38666  1.000 27.47105 ? 281 ILE A CG2 1 
ATOM   2170 C CD1 . ILE A 1 280 ? 5.91240  19.43962  -8.91282  1.000 28.59254 ? 281 ILE A CD1 1 
ATOM   2171 N N   . LEU A 1 281 ? 1.28480  15.70551  -9.09487  1.000 33.18735 ? 282 LEU A N   1 
ATOM   2172 C CA  . LEU A 1 281 ? 0.71351  14.38024  -8.83217  1.000 33.31545 ? 282 LEU A CA  1 
ATOM   2173 C C   . LEU A 1 281 ? -0.22332 14.41074  -7.62776  1.000 40.79798 ? 282 LEU A C   1 
ATOM   2174 O O   . LEU A 1 281 ? -0.22280 13.51073  -6.78508  1.000 42.91050 ? 282 LEU A O   1 
ATOM   2175 C CB  . LEU A 1 281 ? 1.80975  13.33541  -8.63450  1.000 34.58752 ? 282 LEU A CB  1 
ATOM   2176 C CG  . LEU A 1 281 ? 2.39694  12.76258  -9.91948  1.000 31.21742 ? 282 LEU A CG  1 
ATOM   2177 C CD1 . LEU A 1 281 ? 3.60332  11.86366  -9.63758  1.000 26.72377 ? 282 LEU A CD1 1 
ATOM   2178 C CD2 . LEU A 1 281 ? 1.33634  12.00671  -10.69591 1.000 32.96515 ? 282 LEU A CD2 1 
ATOM   2179 N N   . GLY A 1 282 ? -1.02087 15.46915  -7.53827  1.000 41.62234 ? 283 GLY A N   1 
ATOM   2180 C CA  . GLY A 1 282 ? -1.95402 15.60734  -6.43867  1.000 43.98678 ? 283 GLY A CA  1 
ATOM   2181 C C   . GLY A 1 282 ? -1.30766 15.82321  -5.09284  1.000 42.28988 ? 283 GLY A C   1 
ATOM   2182 O O   . GLY A 1 282 ? -1.87039 15.41717  -4.07372  1.000 47.66431 ? 283 GLY A O   1 
ATOM   2183 N N   . SER A 1 283 ? -0.13772 16.45721  -5.05673  1.000 42.66381 ? 284 SER A N   1 
ATOM   2184 C CA  . SER A 1 283 ? 0.61174  16.62068  -3.82191  1.000 39.27429 ? 284 SER A CA  1 
ATOM   2185 C C   . SER A 1 283 ? 1.20123  18.01975  -3.76835  1.000 40.02600 ? 284 SER A C   1 
ATOM   2186 O O   . SER A 1 283 ? 1.73365  18.51481  -4.76527  1.000 37.44800 ? 284 SER A O   1 
ATOM   2187 C CB  . SER A 1 283 ? 1.72686  15.57530  -3.71587  1.000 38.59731 ? 284 SER A CB  1 
ATOM   2188 O OG  . SER A 1 283 ? 2.56393  15.84672  -2.61641  1.000 35.32948 ? 284 SER A OG  1 
ATOM   2189 N N   . ALA A 1 284 ? 1.11008  18.65693  -2.60491  1.000 37.76399 ? 285 ALA A N   1 
ATOM   2190 C CA  . ALA A 1 284 ? 1.66496  19.99118  -2.44020  1.000 39.93288 ? 285 ALA A CA  1 
ATOM   2191 C C   . ALA A 1 284 ? 3.08430  19.97541  -1.89948  1.000 35.24194 ? 285 ALA A C   1 
ATOM   2192 O O   . ALA A 1 284 ? 3.66425  21.04451  -1.69501  1.000 38.43778 ? 285 ALA A O   1 
ATOM   2193 C CB  . ALA A 1 284 ? 0.77281  20.83492  -1.52689  1.000 39.28048 ? 285 ALA A CB  1 
ATOM   2194 N N   . LEU A 1 285 ? 3.65899  18.79881  -1.67246  1.000 34.31730 ? 286 LEU A N   1 
ATOM   2195 C CA  . LEU A 1 285 ? 5.05035  18.66759  -1.27660  1.000 32.37339 ? 286 LEU A CA  1 
ATOM   2196 C C   . LEU A 1 285 ? 5.77103  17.73425  -2.24156  1.000 30.68697 ? 286 LEU A C   1 
ATOM   2197 O O   . LEU A 1 285 ? 5.15281  16.92806  -2.94232  1.000 35.47854 ? 286 LEU A O   1 
ATOM   2198 C CB  . LEU A 1 285 ? 5.18256  18.14659  0.15771   1.000 36.74931 ? 286 LEU A CB  1 
ATOM   2199 C CG  . LEU A 1 285 ? 4.26405  18.77219  1.21076   1.000 41.93930 ? 286 LEU A CG  1 
ATOM   2200 C CD1 . LEU A 1 285 ? 4.31832  17.96392  2.50212   1.000 44.06879 ? 286 LEU A CD1 1 
ATOM   2201 C CD2 . LEU A 1 285 ? 4.63147  20.22309  1.47265   1.000 42.25696 ? 286 LEU A CD2 1 
ATOM   2202 N N   . LEU A 1 286 ? 7.09235  17.86316  -2.28657  1.000 27.68460 ? 287 LEU A N   1 
ATOM   2203 C CA  . LEU A 1 286 ? 7.90046  17.01771  -3.15010  1.000 23.94016 ? 287 LEU A CA  1 
ATOM   2204 C C   . LEU A 1 286 ? 8.08955  15.66749  -2.46484  1.000 25.59476 ? 287 LEU A C   1 
ATOM   2205 O O   . LEU A 1 286 ? 8.54861  15.60765  -1.32505  1.000 28.49590 ? 287 LEU A O   1 
ATOM   2206 C CB  . LEU A 1 286 ? 9.23673  17.69527  -3.44557  1.000 24.56155 ? 287 LEU A CB  1 
ATOM   2207 C CG  . LEU A 1 286 ? 9.08783  19.03313  -4.18704  1.000 27.62393 ? 287 LEU A CG  1 
ATOM   2208 C CD1 . LEU A 1 286 ? 10.42386 19.69838  -4.42150  1.000 28.78113 ? 287 LEU A CD1 1 
ATOM   2209 C CD2 . LEU A 1 286 ? 8.38121  18.81967  -5.49491  1.000 28.49493 ? 287 LEU A CD2 1 
ATOM   2210 N N   . GLU A 1 287 ? 7.70399  14.59483  -3.13639  1.000 21.87693 ? 288 GLU A N   1 
ATOM   2211 C CA  . GLU A 1 287 ? 7.75882  13.25658  -2.55925  1.000 25.75988 ? 288 GLU A CA  1 
ATOM   2212 C C   . GLU A 1 287 ? 9.11675  12.62544  -2.82928  1.000 22.76022 ? 288 GLU A C   1 
ATOM   2213 O O   . GLU A 1 287 ? 9.58140  12.63612  -3.96844  1.000 20.58530 ? 288 GLU A O   1 
ATOM   2214 C CB  . GLU A 1 287 ? 6.66237  12.38173  -3.16506  1.000 24.55823 ? 288 GLU A CB  1 
ATOM   2215 C CG  . GLU A 1 287 ? 5.27832  12.96122  -2.98962  1.000 28.23465 ? 288 GLU A CG  1 
ATOM   2216 C CD  . GLU A 1 287 ? 4.68280  12.61950  -1.64247  1.000 36.75460 ? 288 GLU A CD  1 
ATOM   2217 O OE1 . GLU A 1 287 ? 5.21427  11.70242  -0.97195  1.000 38.55723 ? 288 GLU A OE1 1 
ATOM   2218 O OE2 . GLU A 1 287 ? 3.68395  13.26421  -1.25921  1.000 43.41438 ? 288 GLU A OE2 1 
ATOM   2219 N N   . ASP A 1 288 ? 9.72487  12.01987  -1.79747  1.000 21.76016 ? 289 ASP A N   1 
ATOM   2220 C CA  . ASP A 1 288 ? 11.06471 11.46608  -1.96416  1.000 18.04276 ? 289 ASP A CA  1 
ATOM   2221 C C   . ASP A 1 288 ? 11.16247 9.99742   -1.56109  1.000 20.79765 ? 289 ASP A C   1 
ATOM   2222 O O   . ASP A 1 288 ? 12.26907 9.51228   -1.29596  1.000 19.74427 ? 289 ASP A O   1 
ATOM   2223 C CB  . ASP A 1 288 ? 12.08966 12.30567  -1.19477  1.000 19.22083 ? 289 ASP A CB  1 
ATOM   2224 C CG  . ASP A 1 288 ? 12.13342 11.99600  0.28710   1.000 19.79215 ? 289 ASP A CG  1 
ATOM   2225 O OD1 . ASP A 1 288 ? 11.16039 11.44731  0.83912   1.000 22.00904 ? 289 ASP A OD1 1 
ATOM   2226 O OD2 . ASP A 1 288 ? 13.15472 12.34575  0.91547   1.000 23.51947 ? 289 ASP A OD2 1 
ATOM   2227 N N   . GLU A 1 289 ? 10.04247 9.27516   -1.50465  1.000 18.52411 ? 290 GLU A N   1 
ATOM   2228 C CA  . GLU A 1 289 ? 10.08874 7.86502   -1.13140  1.000 19.29350 ? 290 GLU A CA  1 
ATOM   2229 C C   . GLU A 1 289 ? 9.65871  6.95225   -2.27988  1.000 21.19099 ? 290 GLU A C   1 
ATOM   2230 O O   . GLU A 1 289 ? 9.26340  5.80907   -2.03696  1.000 20.67846 ? 290 GLU A O   1 
ATOM   2231 C CB  . GLU A 1 289 ? 9.26753  7.61985   0.14430   1.000 22.53670 ? 290 GLU A CB  1 
ATOM   2232 C CG  . GLU A 1 289 ? 9.96795  8.21657   1.40384   1.000 24.51824 ? 290 GLU A CG  1 
ATOM   2233 C CD  . GLU A 1 289 ? 9.54043  7.63153   2.76662   1.000 24.89611 ? 290 GLU A CD  1 
ATOM   2234 O OE1 . GLU A 1 289 ? 8.67249  6.73920   2.82346   1.000 24.82382 ? 290 GLU A OE1 1 
ATOM   2235 O OE2 . GLU A 1 289 ? 10.09597 8.09208   3.80058   1.000 22.36716 ? 290 GLU A OE2 1 
ATOM   2236 N N   . PHE A 1 290 ? 9.76363  7.42960   -3.53132  1.000 18.23603 ? 291 PHE A N   1 
ATOM   2237 C CA  . PHE A 1 290 ? 9.71476  6.59702   -4.73646  1.000 17.90881 ? 291 PHE A CA  1 
ATOM   2238 C C   . PHE A 1 290 ? 11.10154 6.54202   -5.38325  1.000 19.10046 ? 291 PHE A C   1 
ATOM   2239 O O   . PHE A 1 290 ? 11.64461 7.58123   -5.76934  1.000 18.24674 ? 291 PHE A O   1 
ATOM   2240 C CB  . PHE A 1 290 ? 8.71260  7.13380   -5.76326  1.000 20.80629 ? 291 PHE A CB  1 
ATOM   2241 C CG  . PHE A 1 290 ? 7.28518  7.07729   -5.31522  1.000 20.20690 ? 291 PHE A CG  1 
ATOM   2242 C CD1 . PHE A 1 290 ? 6.53552  5.92239   -5.50341  1.000 24.96283 ? 291 PHE A CD1 1 
ATOM   2243 C CD2 . PHE A 1 290 ? 6.68603  8.17697   -4.73406  1.000 22.27032 ? 291 PHE A CD2 1 
ATOM   2244 C CE1 . PHE A 1 290 ? 5.21206  5.86316   -5.10329  1.000 26.15345 ? 291 PHE A CE1 1 
ATOM   2245 C CE2 . PHE A 1 290 ? 5.35360  8.12710   -4.32656  1.000 27.76721 ? 291 PHE A CE2 1 
ATOM   2246 C CZ  . PHE A 1 290 ? 4.62306  6.96334   -4.51057  1.000 25.06742 ? 291 PHE A CZ  1 
ATOM   2247 N N   . THR A 1 291 ? 11.64549 5.33199   -5.56724  1.000 18.88425 ? 292 THR A N   1 
ATOM   2248 C CA  . THR A 1 291 ? 12.91747 5.20080   -6.27194  1.000 18.11426 ? 292 THR A CA  1 
ATOM   2249 C C   . THR A 1 291 ? 12.69961 5.25743   -7.77871  1.000 18.67852 ? 292 THR A C   1 
ATOM   2250 O O   . THR A 1 291 ? 11.57121 5.11305   -8.26569  1.000 19.24420 ? 292 THR A O   1 
ATOM   2251 C CB  . THR A 1 291 ? 13.62509 3.88695   -5.92036  1.000 20.91948 ? 292 THR A CB  1 
ATOM   2252 O OG1 . THR A 1 291 ? 12.85264 2.79203   -6.41304  1.000 22.01159 ? 292 THR A OG1 1 
ATOM   2253 C CG2 . THR A 1 291 ? 13.83692 3.72889   -4.41804  1.000 22.47028 ? 292 THR A CG2 1 
ATOM   2254 N N   . PRO A 1 292 ? 13.76540 5.46573   -8.55525  1.000 18.55603 ? 293 PRO A N   1 
ATOM   2255 C CA  . PRO A 1 292 ? 13.60828 5.32905   -10.01224 1.000 21.42061 ? 293 PRO A CA  1 
ATOM   2256 C C   . PRO A 1 292 ? 13.04078 3.98065   -10.40219 1.000 21.22175 ? 293 PRO A C   1 
ATOM   2257 O O   . PRO A 1 292 ? 12.21311 3.90392   -11.31319 1.000 23.00154 ? 293 PRO A O   1 
ATOM   2258 C CB  . PRO A 1 292 ? 15.03343 5.54242   -10.52766 1.000 20.63659 ? 293 PRO A CB  1 
ATOM   2259 C CG  . PRO A 1 292 ? 15.59516 6.54531   -9.54497  1.000 16.75587 ? 293 PRO A CG  1 
ATOM   2260 C CD  . PRO A 1 292 ? 15.05915 6.08453   -8.19802  1.000 20.30138 ? 293 PRO A CD  1 
ATOM   2261 N N   . PHE A 1 293 ? 13.44692 2.91263   -9.70959  1.000 23.80227 ? 294 PHE A N   1 
ATOM   2262 C CA  . PHE A 1 293 ? 12.89492 1.58981   -9.98775  1.000 26.01904 ? 294 PHE A CA  1 
ATOM   2263 C C   . PHE A 1 293 ? 11.40637 1.54300   -9.68215  1.000 26.20689 ? 294 PHE A C   1 
ATOM   2264 O O   . PHE A 1 293 ? 10.61220 1.02660   -10.47904 1.000 27.92179 ? 294 PHE A O   1 
ATOM   2265 C CB  . PHE A 1 293 ? 13.63521 0.52668   -9.17510  1.000 28.77861 ? 294 PHE A CB  1 
ATOM   2266 C CG  . PHE A 1 293 ? 13.22137 -0.87421  -9.50874  1.000 37.25006 ? 294 PHE A CG  1 
ATOM   2267 C CD1 . PHE A 1 293 ? 13.82149 -1.55444  -10.55414 1.000 40.33919 ? 294 PHE A CD1 1 
ATOM   2268 C CD2 . PHE A 1 293 ? 12.22220 -1.50925  -8.78377  1.000 38.19641 ? 294 PHE A CD2 1 
ATOM   2269 C CE1 . PHE A 1 293 ? 13.43625 -2.84638  -10.86408 1.000 46.44888 ? 294 PHE A CE1 1 
ATOM   2270 C CE2 . PHE A 1 293 ? 11.83497 -2.79905  -9.08766  1.000 41.71294 ? 294 PHE A CE2 1 
ATOM   2271 C CZ  . PHE A 1 293 ? 12.43941 -3.46730  -10.13122 1.000 45.76520 ? 294 PHE A CZ  1 
ATOM   2272 N N   . ASP A 1 294 ? 11.01960 2.04862   -8.50875  1.000 21.51513 ? 295 ASP A N   1 
ATOM   2273 C CA  . ASP A 1 294 ? 9.61075  2.16139   -8.14678  1.000 23.42614 ? 295 ASP A CA  1 
ATOM   2274 C C   . ASP A 1 294 ? 8.79550  2.80979   -9.25881  1.000 28.73483 ? 295 ASP A C   1 
ATOM   2275 O O   . ASP A 1 294 ? 7.73465  2.30406   -9.65192  1.000 26.38270 ? 295 ASP A O   1 
ATOM   2276 C CB  . ASP A 1 294 ? 9.48114  2.96422   -6.85338  1.000 21.64908 ? 295 ASP A CB  1 
ATOM   2277 C CG  . ASP A 1 294 ? 9.98935  2.19959   -5.65176  1.000 24.81569 ? 295 ASP A CG  1 
ATOM   2278 O OD1 . ASP A 1 294 ? 10.10548 0.96051   -5.77148  1.000 31.66503 ? 295 ASP A OD1 1 
ATOM   2279 O OD2 . ASP A 1 294 ? 10.27473 2.81460   -4.59643  1.000 24.60553 ? 295 ASP A OD2 1 
ATOM   2280 N N   . VAL A 1 295 ? 9.26799  3.95049   -9.75931  1.000 24.43128 ? 296 VAL A N   1 
ATOM   2281 C CA  . VAL A 1 295 ? 8.53823  4.65037   -10.81337 1.000 24.42857 ? 296 VAL A CA  1 
ATOM   2282 C C   . VAL A 1 295 ? 8.47464  3.79073   -12.06242 1.000 27.78511 ? 296 VAL A C   1 
ATOM   2283 O O   . VAL A 1 295 ? 7.40959  3.62169   -12.67045 1.000 30.66196 ? 296 VAL A O   1 
ATOM   2284 C CB  . VAL A 1 295 ? 9.19029  6.01221   -11.10478 1.000 22.13925 ? 296 VAL A CB  1 
ATOM   2285 C CG1 . VAL A 1 295 ? 8.50332  6.67030   -12.31125 1.000 25.56022 ? 296 VAL A CG1 1 
ATOM   2286 C CG2 . VAL A 1 295 ? 9.11674  6.89401   -9.88991  1.000 22.31431 ? 296 VAL A CG2 1 
ATOM   2287 N N   . VAL A 1 296 ? 9.61822  3.23657   -12.46671 1.000 26.36876 ? 297 VAL A N   1 
ATOM   2288 C CA  . VAL A 1 296 ? 9.66574  2.45541   -13.69728 1.000 30.15623 ? 297 VAL A CA  1 
ATOM   2289 C C   . VAL A 1 296 ? 8.65957  1.31823   -13.62942 1.000 34.46469 ? 297 VAL A C   1 
ATOM   2290 O O   . VAL A 1 296 ? 7.88866  1.08603   -14.56625 1.000 36.63866 ? 297 VAL A O   1 
ATOM   2291 C CB  . VAL A 1 296 ? 11.09451 1.94009   -13.94690 1.000 31.84868 ? 297 VAL A CB  1 
ATOM   2292 C CG1 . VAL A 1 296 ? 11.07958 0.75375   -14.88466 1.000 34.18092 ? 297 VAL A CG1 1 
ATOM   2293 C CG2 . VAL A 1 296 ? 11.95790 3.04325   -14.52141 1.000 31.03863 ? 297 VAL A CG2 1 
ATOM   2294 N N   . ARG A 1 297 ? 8.60535  0.63683   -12.49118 1.000 32.41532 ? 298 ARG A N   1 
ATOM   2295 C CA  . ARG A 1 297 ? 7.77915  -0.55754  -12.40046 1.000 34.71234 ? 298 ARG A CA  1 
ATOM   2296 C C   . ARG A 1 297 ? 6.28867  -0.21795  -12.30189 1.000 38.33875 ? 298 ARG A C   1 
ATOM   2297 O O   . ARG A 1 297 ? 5.46117  -0.91325  -12.90778 1.000 36.47534 ? 298 ARG A O   1 
ATOM   2298 C CB  . ARG A 1 297 ? 8.29546  -1.42781  -11.24726 1.000 33.28595 ? 298 ARG A CB  1 
ATOM   2299 C CG  . ARG A 1 297 ? 7.69640  -1.13782  -9.89121  1.000 37.80967 ? 298 ARG A CG  1 
ATOM   2300 C CD  . ARG A 1 297 ? 7.89754  -2.33077  -8.94258  1.000 41.97055 ? 298 ARG A CD  1 
ATOM   2301 N NE  . ARG A 1 297 ? 7.85979  -1.91994  -7.54388  1.000 44.66946 ? 298 ARG A NE  1 
ATOM   2302 C CZ  . ARG A 1 297 ? 6.87535  -2.22220  -6.70300  1.000 43.29962 ? 298 ARG A CZ  1 
ATOM   2303 N NH1 . ARG A 1 297 ? 6.90031  -1.81511  -5.45075  1.000 40.14792 ? 298 ARG A NH1 1 
ATOM   2304 N NH2 . ARG A 1 297 ? 5.86514  -2.97636  -7.10565  1.000 41.52549 ? 298 ARG A NH2 1 
ATOM   2305 N N   . GLN A 1 298 ? 5.92303  0.87817   -11.63037 1.000 32.54836 ? 299 GLN A N   1 
ATOM   2306 C CA  . GLN A 1 298 ? 4.51188  1.24922   -11.58556 1.000 31.65894 ? 299 GLN A CA  1 
ATOM   2307 C C   . GLN A 1 298 ? 4.05898  1.85866   -12.89982 1.000 34.81517 ? 299 GLN A C   1 
ATOM   2308 O O   . GLN A 1 298 ? 2.87887  1.75612   -13.25958 1.000 35.29036 ? 299 GLN A O   1 
ATOM   2309 C CB  . GLN A 1 298 ? 4.23254  2.22018   -10.43502 1.000 29.43540 ? 299 GLN A CB  1 
ATOM   2310 C CG  . GLN A 1 298 ? 2.77882  2.66841   -10.35829 1.000 29.69006 ? 299 GLN A CG  1 
ATOM   2311 C CD  . GLN A 1 298 ? 2.41294  3.31496   -9.04209  1.000 29.45962 ? 299 GLN A CD  1 
ATOM   2312 O OE1 . GLN A 1 298 ? 1.30357  3.82862   -8.87967  1.000 28.58966 ? 299 GLN A OE1 1 
ATOM   2313 N NE2 . GLN A 1 298 ? 3.34849  3.30990   -8.09246  1.000 28.54496 ? 299 GLN A NE2 1 
ATOM   2314 N N   . CYS A 1 299 ? 4.97167  2.47464   -13.63891 1.000 33.58583 ? 300 CYS A N   1 
ATOM   2315 C CA  . CYS A 1 299 ? 4.64046  3.01427   -14.94495 1.000 38.19655 ? 300 CYS A CA  1 
ATOM   2316 C C   . CYS A 1 299 ? 4.95230  2.03721   -16.07833 1.000 37.72838 ? 300 CYS A C   1 
ATOM   2317 O O   . CYS A 1 299 ? 4.74495  2.38139   -17.24573 1.000 46.27067 ? 300 CYS A O   1 
ATOM   2318 C CB  . CYS A 1 299 ? 5.36297  4.35508   -15.15153 1.000 35.20059 ? 300 CYS A CB  1 
ATOM   2319 S SG  . CYS A 1 299 ? 4.91101  5.63245   -13.89148 1.000 37.89233 ? 300 CYS A SG  1 
ATOM   2320 N N   . SER A 1 300 ? 5.40931  0.81288   -15.76087 1.000 42.45014 ? 301 SER A N   1 
ATOM   2321 C CA  . SER A 1 300 ? 5.63870  -0.22846  -16.76458 1.000 37.57977 ? 301 SER A CA  1 
ATOM   2322 C C   . SER A 1 300 ? 5.09005  -1.60305  -16.39343 1.000 40.40651 ? 301 SER A C   1 
ATOM   2323 O O   . SER A 1 300 ? 5.12202  -2.49983  -17.24104 1.000 41.19885 ? 301 SER A O   1 
ATOM   2324 C CB  . SER A 1 300 ? 7.13847  -0.36805  -17.06842 1.000 45.35106 ? 301 SER A CB  1 
ATOM   2325 O OG  . SER A 1 300 ? 7.69514  0.88757   -17.44716 1.000 44.46511 ? 301 SER A OG  1 
ATOM   2326 N N   . GLY A 1 301 ? 4.61724  -1.80908  -15.16686 1.000 40.08239 ? 302 GLY A N   1 
ATOM   2327 C CA  . GLY A 1 301 ? 3.88712  -3.01925  -14.82554 1.000 36.54531 ? 302 GLY A CA  1 
ATOM   2328 C C   . GLY A 1 301 ? 4.72746  -4.25316  -14.57284 1.000 39.49517 ? 302 GLY A C   1 
ATOM   2329 O O   . GLY A 1 301 ? 4.33341  -5.35993  -14.96703 1.000 37.43286 ? 302 GLY A O   1 
ATOM   2330 N N   . VAL A 1 302 ? 5.88132  -4.09489  -13.92202 1.000 39.02136 ? 303 VAL A N   1 
ATOM   2331 C CA  . VAL A 1 302 ? 6.73950  -5.23717  -13.62795 1.000 42.15808 ? 303 VAL A CA  1 
ATOM   2332 C C   . VAL A 1 302 ? 6.00005  -6.19805  -12.70845 1.000 42.55374 ? 303 VAL A C   1 
ATOM   2333 O O   . VAL A 1 302 ? 5.40730  -5.78753  -11.70315 1.000 40.35598 ? 303 VAL A O   1 
ATOM   2334 C CB  . VAL A 1 302 ? 8.06580  -4.75798  -13.01080 1.000 43.00080 ? 303 VAL A CB  1 
ATOM   2335 C CG1 . VAL A 1 302 ? 8.93700  -5.93876  -12.59690 1.000 44.78047 ? 303 VAL A CG1 1 
ATOM   2336 C CG2 . VAL A 1 302 ? 8.81125  -3.86190  -13.99962 1.000 44.36439 ? 303 VAL A CG2 1 
ATOM   2337 N N   . THR A 1 303 ? 6.01157  -7.48163  -13.06180 1.000 38.76204 ? 304 THR A N   1 
ATOM   2338 C CA  . THR A 1 303 ? 5.41560  -8.51406  -12.21611 1.000 40.62023 ? 304 THR A CA  1 
ATOM   2339 C C   . THR A 1 303 ? 6.50734  -9.39756  -11.60623 1.000 44.92486 ? 304 THR A C   1 
ATOM   2340 O O   . THR A 1 303 ? 6.22944  -10.26160 -10.76894 1.000 47.25285 ? 304 THR A O   1 
ATOM   2341 C CB  . THR A 1 303 ? 4.41365  -9.40604  -13.00088 1.000 39.44238 ? 304 THR A CB  1 
ATOM   2342 O OG1 . THR A 1 303 ? 5.04094  -9.92232  -14.18199 1.000 40.23976 ? 304 THR A OG1 1 
ATOM   2343 C CG2 . THR A 1 303 ? 3.16688  -8.61892  -13.39761 1.000 30.43867 ? 304 THR A CG2 1 
HETATM 2344 C C02 . X77 B 2 .   ? 6.83930  -2.64511  21.51660  1.000 26.04320 ? 401 X77 A C02 1 
HETATM 2345 C C04 . X77 B 2 .   ? 7.40663  -0.19176  21.24380  1.000 24.22395 ? 401 X77 A C04 1 
HETATM 2346 C C05 . X77 B 2 .   ? 8.56032  0.75039   21.49419  1.000 25.68770 ? 401 X77 A C05 1 
HETATM 2347 C C07 . X77 B 2 .   ? 9.29866  2.46252   23.37088  1.000 33.64691 ? 401 X77 A C07 1 
HETATM 2348 C C08 . X77 B 2 .   ? 10.62284 1.81572   23.76242  1.000 33.21334 ? 401 X77 A C08 1 
HETATM 2349 C C09 . X77 B 2 .   ? 11.60718 2.87409   24.25759  1.000 27.53429 ? 401 X77 A C09 1 
HETATM 2350 C C10 . X77 B 2 .   ? 10.94961 4.23486   24.51049  1.000 34.20022 ? 401 X77 A C10 1 
HETATM 2351 C C11 . X77 B 2 .   ? 10.25496 4.76434   23.25172  1.000 31.10267 ? 401 X77 A C11 1 
HETATM 2352 C C12 . X77 B 2 .   ? 9.47565  3.68942   22.49766  1.000 32.92128 ? 401 X77 A C12 1 
HETATM 2353 C C14 . X77 B 2 .   ? 6.93560  0.06286   19.82830  1.000 22.89552 ? 401 X77 A C14 1 
HETATM 2354 C C15 . X77 B 2 .   ? 5.81363  1.04165   19.67419  1.000 23.79475 ? 401 X77 A C15 1 
HETATM 2355 C C16 . X77 B 2 .   ? 5.30374  1.37562   18.31429  1.000 25.87160 ? 401 X77 A C16 1 
HETATM 2356 C C17 . X77 B 2 .   ? 5.99063  0.68999   17.14222  1.000 24.27285 ? 401 X77 A C17 1 
HETATM 2357 C C19 . X77 B 2 .   ? 7.61774  -0.62605  18.66300  1.000 22.35838 ? 401 X77 A C19 1 
HETATM 2358 C C20 . X77 B 2 .   ? 9.13102  -1.72769  22.20081  1.000 25.97055 ? 401 X77 A C20 1 
HETATM 2359 C C21 . X77 B 2 .   ? 9.20602  -1.54006  23.70114  1.000 24.80082 ? 401 X77 A C21 1 
HETATM 2360 C C22 . X77 B 2 .   ? 10.55595 -1.68054  24.39646  1.000 26.79630 ? 401 X77 A C22 1 
HETATM 2361 C C23 . X77 B 2 .   ? 11.79263 -2.01919  23.55127  1.000 22.34291 ? 401 X77 A C23 1 
HETATM 2362 C C24 . X77 B 2 .   ? 13.11595 -2.17201  24.29628  1.000 25.57251 ? 401 X77 A C24 1 
HETATM 2363 C C25 . X77 B 2 .   ? 13.29705 -0.89904  25.11194  1.000 27.46913 ? 401 X77 A C25 1 
HETATM 2364 C C26 . X77 B 2 .   ? 14.21448 -2.38468  23.27933  1.000 23.88021 ? 401 X77 A C26 1 
HETATM 2365 C C27 . X77 B 2 .   ? 13.00784 -3.39386  25.23426  1.000 26.40241 ? 401 X77 A C27 1 
HETATM 2366 C C28 . X77 B 2 .   ? 11.72359 -2.20551  22.04376  1.000 22.87993 ? 401 X77 A C28 1 
HETATM 2367 C C29 . X77 B 2 .   ? 10.36776 -2.06625  21.35316  1.000 24.40854 ? 401 X77 A C29 1 
HETATM 2368 C C30 . X77 B 2 .   ? 7.16687  -4.07900  21.96591  1.000 23.22466 ? 401 X77 A C30 1 
HETATM 2369 C C31 . X77 B 2 .   ? 6.28225  -5.11664  21.87443  1.000 25.33476 ? 401 X77 A C31 1 
HETATM 2370 C C33 . X77 B 2 .   ? 8.08789  -5.84850  22.78583  1.000 20.63474 ? 401 X77 A C33 1 
HETATM 2371 N N03 . X77 B 2 .   ? 7.79841  -1.54294  21.60813  1.000 21.18586 ? 401 X77 A N03 1 
HETATM 2372 N N06 . X77 B 2 .   ? 8.40278  1.47545   22.75567  1.000 25.99127 ? 401 X77 A N06 1 
HETATM 2373 N N18 . X77 B 2 .   ? 7.10030  -0.28363  17.32507  1.000 21.46553 ? 401 X77 A N18 1 
HETATM 2374 N N32 . X77 B 2 .   ? 6.85873  -6.18617  22.36654  1.000 27.86821 ? 401 X77 A N32 1 
HETATM 2375 N N34 . X77 B 2 .   ? 8.26744  -4.53583  22.53548  1.000 27.48522 ? 401 X77 A N34 1 
HETATM 2376 O O01 . X77 B 2 .   ? 5.77706  -2.38917  21.07392  1.000 25.99955 ? 401 X77 A O01 1 
HETATM 2377 O O13 . X77 B 2 .   ? 9.47445  0.87838   20.73426  1.000 24.17968 ? 401 X77 A O13 1 
HETATM 2378 O O   . HOH C 3 .   ? 4.528    -4.065    -5.931    1.000 40.56213 ? 501 HOH A O   1 
HETATM 2379 O O   . HOH C 3 .   ? 3.72570  -10.26654 -16.05743 1.000 37.82543 ? 502 HOH A O   1 
HETATM 2380 O O   . HOH C 3 .   ? 7.489    6.342     4.781     1.000 30.66305 ? 503 HOH A O   1 
HETATM 2381 O O   . HOH C 3 .   ? 11.51879 19.44952  -0.65346  1.000 33.92696 ? 504 HOH A O   1 
HETATM 2382 O O   . HOH C 3 .   ? 6.95865  5.48812   1.68217   1.000 27.71971 ? 505 HOH A O   1 
HETATM 2383 O O   . HOH C 3 .   ? -1.21121 17.70059  -9.43602  1.000 39.18017 ? 506 HOH A O   1 
HETATM 2384 O O   . HOH C 3 .   ? 16.03130 17.38083  -22.14550 1.000 31.91491 ? 507 HOH A O   1 
HETATM 2385 O O   . HOH C 3 .   ? 14.82637 18.89924  2.42329   1.000 34.79331 ? 508 HOH A O   1 
HETATM 2386 O O   . HOH C 3 .   ? 0.40908  -1.47870  11.81207  1.000 28.52625 ? 509 HOH A O   1 
HETATM 2387 O O   . HOH C 3 .   ? 10.10531 24.31147  -12.02473 1.000 32.41278 ? 510 HOH A O   1 
HETATM 2388 O O   . HOH C 3 .   ? 24.36674 11.38746  -2.41485  1.000 34.08047 ? 511 HOH A O   1 
HETATM 2389 O O   . HOH C 3 .   ? 28.31386 6.62727   -12.80542 1.000 38.33146 ? 512 HOH A O   1 
HETATM 2390 O O   . HOH C 3 .   ? -0.76870 3.53147   -1.35933  1.000 28.78975 ? 513 HOH A O   1 
HETATM 2391 O O   . HOH C 3 .   ? 19.66010 -20.81749 17.34109  1.000 34.81674 ? 514 HOH A O   1 
HETATM 2392 O O   . HOH C 3 .   ? 4.13383  14.30684  -20.31579 1.000 36.88568 ? 515 HOH A O   1 
HETATM 2393 O O   . HOH C 3 .   ? 0.49112  -7.91594  20.54327  1.000 42.48469 ? 516 HOH A O   1 
HETATM 2394 O O   . HOH C 3 .   ? 7.19417  10.05177  -0.78771  1.000 26.80710 ? 517 HOH A O   1 
HETATM 2395 O O   . HOH C 3 .   ? 13.26507 0.39765   -5.53241  1.000 27.02583 ? 518 HOH A O   1 
HETATM 2396 O O   . HOH C 3 .   ? 10.61912 5.99934   5.71891   1.000 24.21954 ? 519 HOH A O   1 
HETATM 2397 O O   . HOH C 3 .   ? 2.60309  -8.63530  18.74746  1.000 26.52417 ? 520 HOH A O   1 
HETATM 2398 O O   . HOH C 3 .   ? 20.58850 -14.20577 10.64379  1.000 27.96370 ? 521 HOH A O   1 
HETATM 2399 O O   . HOH C 3 .   ? 3.37104  3.93860   2.26768   1.000 25.47680 ? 522 HOH A O   1 
HETATM 2400 O O   . HOH C 3 .   ? 24.48565 25.60447  -14.53054 1.000 43.37406 ? 523 HOH A O   1 
HETATM 2401 O O   . HOH C 3 .   ? 5.18210  -18.35245 2.09331   1.000 29.17933 ? 524 HOH A O   1 
HETATM 2402 O O   . HOH C 3 .   ? 24.70781 -10.08477 20.18865  1.000 25.75126 ? 525 HOH A O   1 
HETATM 2403 O O   . HOH C 3 .   ? 10.61671 -1.22337  -3.18380  1.000 25.51766 ? 526 HOH A O   1 
HETATM 2404 O O   . HOH C 3 .   ? -0.33180 1.09569   11.99688  1.000 34.21506 ? 527 HOH A O   1 
HETATM 2405 O O   . HOH C 3 .   ? 17.05532 1.82941   12.03832  1.000 19.74576 ? 528 HOH A O   1 
HETATM 2406 O O   . HOH C 3 .   ? 27.97362 -7.85740  12.66426  1.000 25.41873 ? 529 HOH A O   1 
HETATM 2407 O O   . HOH C 3 .   ? 25.94327 -5.02180  14.74420  1.000 31.93195 ? 530 HOH A O   1 
HETATM 2408 O O   . HOH C 3 .   ? 3.22163  3.78575   17.32242  1.000 35.18089 ? 531 HOH A O   1 
HETATM 2409 O O   . HOH C 3 .   ? 5.44831  -12.80393 -10.39894 1.000 43.20940 ? 532 HOH A O   1 
HETATM 2410 O O   . HOH C 3 .   ? 17.34950 -29.55545 21.64695  1.000 43.22992 ? 533 HOH A O   1 
HETATM 2411 O O   . HOH C 3 .   ? 19.98129 8.24910   27.74740  1.000 34.89404 ? 534 HOH A O   1 
HETATM 2412 O O   . HOH C 3 .   ? 23.66522 0.90183   15.90951  1.000 24.02954 ? 535 HOH A O   1 
HETATM 2413 O O   . HOH C 3 .   ? 10.36627 -11.18581 28.53213  1.000 40.69321 ? 536 HOH A O   1 
HETATM 2414 O O   . HOH C 3 .   ? 11.224   -35.174   22.146    1.000 42.54298 ? 537 HOH A O   1 
HETATM 2415 O O   . HOH C 3 .   ? 29.95329 24.76981  -11.05107 1.000 39.73513 ? 538 HOH A O   1 
HETATM 2416 O O   . HOH C 3 .   ? 24.96769 -1.36983  12.81901  1.000 34.55971 ? 539 HOH A O   1 
HETATM 2417 O O   . HOH C 3 .   ? 19.15226 -8.49088  5.84713   1.000 23.67339 ? 540 HOH A O   1 
HETATM 2418 O O   . HOH C 3 .   ? 21.37054 9.13343   -17.33463 1.000 29.86058 ? 541 HOH A O   1 
HETATM 2419 O O   . HOH C 3 .   ? 27.26019 4.11186   -14.91122 1.000 38.38842 ? 542 HOH A O   1 
HETATM 2420 O O   . HOH C 3 .   ? 21.10030 8.59632   12.17588  1.000 23.98500 ? 543 HOH A O   1 
HETATM 2421 O O   . HOH C 3 .   ? 6.36959  -9.22603  8.55649   1.000 24.83446 ? 544 HOH A O   1 
HETATM 2422 O O   . HOH C 3 .   ? 21.65425 8.04070   18.73706  1.000 30.54661 ? 545 HOH A O   1 
HETATM 2423 O O   . HOH C 3 .   ? 9.95986  10.02715  -4.70842  1.000 20.20125 ? 546 HOH A O   1 
HETATM 2424 O O   . HOH C 3 .   ? 8.10002  4.17168   -0.16468  1.000 28.01414 ? 547 HOH A O   1 
HETATM 2425 O O   . HOH C 3 .   ? 21.02443 -14.50425 2.07714   1.000 29.75033 ? 548 HOH A O   1 
HETATM 2426 O O   . HOH C 3 .   ? 16.26303 -6.36738  19.96512  1.000 18.12141 ? 549 HOH A O   1 
HETATM 2427 O O   . HOH C 3 .   ? 15.01797 -21.32825 32.21443  1.000 40.30278 ? 550 HOH A O   1 
HETATM 2428 O O   . HOH C 3 .   ? 16.59351 -20.13122 8.22200   1.000 29.71733 ? 551 HOH A O   1 
HETATM 2429 O O   . HOH C 3 .   ? 14.38495 -21.23005 0.40245   1.000 33.93789 ? 552 HOH A O   1 
HETATM 2430 O O   . HOH C 3 .   ? 15.17809 -5.96379  -0.09385  1.000 24.33044 ? 553 HOH A O   1 
HETATM 2431 O O   . HOH C 3 .   ? 10.33014 -7.01103  23.95202  1.000 28.04155 ? 554 HOH A O   1 
HETATM 2432 O O   . HOH C 3 .   ? 22.85998 8.48856   4.42617   1.000 34.69448 ? 555 HOH A O   1 
HETATM 2433 O O   . HOH C 3 .   ? 24.21392 -16.97449 21.19309  1.000 28.15564 ? 556 HOH A O   1 
HETATM 2434 O O   . HOH C 3 .   ? 24.84631 2.39508   3.62968   1.000 39.13486 ? 557 HOH A O   1 
HETATM 2435 O O   . HOH C 3 .   ? 29.46267 12.32886  -9.18993  1.000 40.74955 ? 558 HOH A O   1 
HETATM 2436 O O   . HOH C 3 .   ? 13.634   -27.117   27.383    1.000 39.81578 ? 559 HOH A O   1 
HETATM 2437 O O   . HOH C 3 .   ? 25.52860 12.38955  -17.18875 1.000 41.24425 ? 560 HOH A O   1 
HETATM 2438 O O   . HOH C 3 .   ? 17.07236 5.63319   -4.29711  1.000 30.32634 ? 561 HOH A O   1 
HETATM 2439 O O   . HOH C 3 .   ? 22.01846 -2.87535  26.37683  1.000 33.22104 ? 562 HOH A O   1 
HETATM 2440 O O   . HOH C 3 .   ? 19.66866 28.58824  -20.92194 1.000 35.53010 ? 563 HOH A O   1 
HETATM 2441 O O   . HOH C 3 .   ? 23.44083 -6.82967  1.25688   1.000 36.26048 ? 564 HOH A O   1 
HETATM 2442 O O   . HOH C 3 .   ? 22.23072 -2.74735  20.20096  1.000 22.40738 ? 565 HOH A O   1 
HETATM 2443 O O   . HOH C 3 .   ? 25.88321 7.54663   -5.29816  1.000 29.55890 ? 566 HOH A O   1 
HETATM 2444 O O   . HOH C 3 .   ? -4.00564 -12.72962 2.55425   1.000 27.16639 ? 567 HOH A O   1 
HETATM 2445 O O   . HOH C 3 .   ? 24.05611 1.85811   9.53032   1.000 27.89024 ? 568 HOH A O   1 
HETATM 2446 O O   . HOH C 3 .   ? 23.42187 -3.58337  15.84093  1.000 22.11489 ? 569 HOH A O   1 
HETATM 2447 O O   . HOH C 3 .   ? 2.01586  1.36554   0.09195   1.000 20.43300 ? 570 HOH A O   1 
HETATM 2448 O O   . HOH C 3 .   ? 13.97334 10.66223  11.02837  1.000 26.27769 ? 571 HOH A O   1 
HETATM 2449 O O   . HOH C 3 .   ? 17.56719 -24.81851 26.72639  1.000 33.08901 ? 572 HOH A O   1 
HETATM 2450 O O   . HOH C 3 .   ? 23.24558 0.84291   4.70241   1.000 29.82224 ? 573 HOH A O   1 
HETATM 2451 O O   . HOH C 3 .   ? 15.24099 5.63020   -14.23745 1.000 27.83670 ? 574 HOH A O   1 
HETATM 2452 O O   . HOH C 3 .   ? 24.39111 -15.34742 25.75076  1.000 28.94690 ? 575 HOH A O   1 
HETATM 2453 O O   . HOH C 3 .   ? 6.69987  7.11011   11.54412  1.000 27.59112 ? 576 HOH A O   1 
HETATM 2454 O O   . HOH C 3 .   ? 23.17536 -1.70271  17.94623  1.000 24.48623 ? 577 HOH A O   1 
HETATM 2455 O O   . HOH C 3 .   ? 28.85046 8.68911   -8.82479  1.000 36.89109 ? 578 HOH A O   1 
HETATM 2456 O O   . HOH C 3 .   ? 3.71423  28.04411  -11.78308 1.000 44.02357 ? 579 HOH A O   1 
HETATM 2457 O O   . HOH C 3 .   ? 2.26322  11.93082  -5.45973  1.000 37.39413 ? 580 HOH A O   1 
HETATM 2458 O O   . HOH C 3 .   ? 20.27815 26.64718  -18.85011 1.000 33.33309 ? 581 HOH A O   1 
HETATM 2459 O O   . HOH C 3 .   ? 17.538   2.472     -13.407   1.000 34.32154 ? 582 HOH A O   1 
HETATM 2460 O O   . HOH C 3 .   ? 9.62214  -18.75975 -3.59928  1.000 34.65047 ? 583 HOH A O   1 
HETATM 2461 O O   . HOH C 3 .   ? 8.23772  12.02072  0.96725   1.000 35.70539 ? 584 HOH A O   1 
HETATM 2462 O O   . HOH C 3 .   ? 15.90323 2.60797   -8.04516  1.000 31.23544 ? 585 HOH A O   1 
HETATM 2463 O O   . HOH C 3 .   ? 20.46486 -23.73032 22.55362  1.000 33.99466 ? 586 HOH A O   1 
HETATM 2464 O O   . HOH C 3 .   ? 15.74244 16.27706  10.73096  1.000 34.76346 ? 587 HOH A O   1 
HETATM 2465 O O   . HOH C 3 .   ? 21.43931 -2.43757  23.88277  1.000 26.31104 ? 588 HOH A O   1 
HETATM 2466 O O   . HOH C 3 .   ? 5.93292  1.52401   -7.37309  1.000 33.50807 ? 589 HOH A O   1 
HETATM 2467 O O   . HOH C 3 .   ? -0.00000 -0.91464  0.00000   0.50  23.58948 ? 590 HOH A O   1 
HETATM 2468 O O   . HOH C 3 .   ? 27.40446 18.37837  -15.00987 1.000 34.88775 ? 591 HOH A O   1 
HETATM 2469 O O   . HOH C 3 .   ? 20.07254 11.45259  -3.91290  1.000 24.83459 ? 592 HOH A O   1 
HETATM 2470 O O   . HOH C 3 .   ? 24.49893 0.63645   6.74969   1.000 34.37037 ? 593 HOH A O   1 
HETATM 2471 O O   . HOH C 3 .   ? 16.29278 -19.71466 -0.83570  1.000 30.36666 ? 594 HOH A O   1 
HETATM 2472 O O   . HOH C 3 .   ? 23.16877 -9.02912  34.31568  1.000 38.60597 ? 595 HOH A O   1 
HETATM 2473 O O   . HOH C 3 .   ? 5.59863  2.42985   -4.86870  1.000 21.91095 ? 596 HOH A O   1 
HETATM 2474 O O   . HOH C 3 .   ? 21.75313 15.06424  -18.24834 1.000 31.11839 ? 597 HOH A O   1 
HETATM 2475 O O   . HOH C 3 .   ? 27.19294 -12.15882 11.62654  1.000 41.36855 ? 598 HOH A O   1 
HETATM 2476 O O   . HOH C 3 .   ? 14.64793 -0.06609  -3.52112  1.000 31.36697 ? 599 HOH A O   1 
HETATM 2477 O O   . HOH C 3 .   ? 26.62836 -9.61348  10.40458  1.000 31.35743 ? 600 HOH A O   1 
HETATM 2478 O O   . HOH C 3 .   ? 3.06556  4.47994   13.56436  1.000 29.81561 ? 601 HOH A O   1 
HETATM 2479 O O   . HOH C 3 .   ? 20.70252 -22.13707 28.46077  1.000 33.82923 ? 602 HOH A O   1 
HETATM 2480 O O   . HOH C 3 .   ? 15.43206 -22.76890 1.83695   1.000 38.48088 ? 603 HOH A O   1 
HETATM 2481 O O   . HOH C 3 .   ? 22.28799 6.05669   -18.05733 1.000 33.69807 ? 604 HOH A O   1 
HETATM 2482 O O   . HOH C 3 .   ? 23.94561 -6.32382  25.86874  1.000 29.71414 ? 605 HOH A O   1 
HETATM 2483 O O   . HOH C 3 .   ? 22.67421 -22.07299 23.63884  1.000 40.02023 ? 606 HOH A O   1 
HETATM 2484 O O   . HOH C 3 .   ? 23.30826 -19.17535 23.26112  1.000 32.98704 ? 607 HOH A O   1 
HETATM 2485 O O   . HOH C 3 .   ? 23.94139 -9.38301  1.52056   1.000 44.25163 ? 608 HOH A O   1 
HETATM 2486 O O   . HOH C 3 .   ? 31.160   19.928    -4.593    1.000 40.71300 ? 609 HOH A O   1 
HETATM 2487 O O   . HOH C 3 .   ? 15.32910 13.54137  13.59178  1.000 37.58455 ? 610 HOH A O   1 
HETATM 2488 O O   . HOH C 3 .   ? -0.247   5.361     -12.955   1.000 38.25482 ? 611 HOH A O   1 
HETATM 2489 O O   . HOH C 3 .   ? 16.25279 -6.44762  -2.34431  1.000 32.61511 ? 612 HOH A O   1 
HETATM 2490 O O   . HOH C 3 .   ? 25.37458 8.24685   -3.10829  1.000 35.49030 ? 613 HOH A O   1 
HETATM 2491 O O   . HOH C 3 .   ? 15.60855 -29.74129 23.21475  1.000 38.91011 ? 614 HOH A O   1 
HETATM 2492 O O   . HOH C 3 .   ? 23.61248 -2.43024  22.39796  1.000 37.15853 ? 615 HOH A O   1 
HETATM 2493 O O   . HOH C 3 .   ? 13.54233 11.66718  13.28478  1.000 35.23048 ? 616 HOH A O   1 
HETATM 2494 O O   . HOH C 3 .   ? 14.54844 -7.58952  -4.66073  1.000 38.75424 ? 617 HOH A O   1 
HETATM 2495 O O   . HOH C 3 .   ? 20.37378 9.75850   -2.01959  1.000 32.21399 ? 618 HOH A O   1 
HETATM 2496 O O   . HOH C 3 .   ? 9.74593  -2.49979  -16.85609 1.000 43.36466 ? 619 HOH A O   1 
HETATM 2497 O O   . HOH C 3 .   ? 25.215   -15.530   33.730    1.000 41.05383 ? 620 HOH A O   1 
HETATM 2498 O O   . HOH C 3 .   ? 23.08866 8.93999   10.33362  1.000 37.64579 ? 621 HOH A O   1 
HETATM 2499 O O   . HOH C 3 .   ? 23.70004 -0.28518  24.36703  1.000 38.39020 ? 622 HOH A O   1 
HETATM 2500 O O   . HOH C 3 .   ? 16.828   0.740     -10.975   1.000 39.25978 ? 623 HOH A O   1 
HETATM 2501 O O   . HOH C 3 .   ? 24.09090 -18.16855 25.39071  1.000 28.95153 ? 624 HOH A O   1 
HETATM 2502 O O   . HOH C 3 .   ? 25.26300 -15.03937 23.04422  1.000 35.49901 ? 625 HOH A O   1 
# 
